gebhart/patrepeval huggingface dataset:
iSpot Lyme™: A New Generation of Lyme Disease Testing (2013)

Lyme disease is the most reported vectorborne illness in the United States. The incidence may be vastly under-reported due to limitations of current testing methodologies; the need for more sensitive and specific tests is apparent. The iSpot Lyme™ assay is a new generation of in vitro diagnostic test for the detection of antigen-specific effector/memory T cells that respond to stimulation by Borrelia burgdorferi antigens. The highly sensitive T cell-based enzyme-linked immunospot (ELISPOT) methodology enumerates the Borrelia burgdorferi activated effector/memory T cells. This assay is intended for clinical use as a laboratory aid in the diagnosis of B. burgdorferi infection. The iSpot Lyme™ test represents a breakthrough in diagnostic accuracy with improved sensitivity and specificity over current Lyme disease testing methodologies, and can increase the speed of diagnosis and treatment.
Motion Trajectory Learning in the DFT-Coefficient Feature Space (2006)

Techniques for understanding video object motion activity are becoming increasingly important with the widespread adoption of CCTV surveillance systems. In this paper we propose a novel vision system for clustering and classification of object-based video motion clips using spatiotemporal models. Object trajectories are modeled as motion time series using the lowest order Fourier coefficients obtained by Discrete Fourier Transform. Trajectory clustering is then carried out in the DFT-coefficient feature space to discover patterns of similar object motion activity. The DFT coefficients are used as input feature vectors to a Self-Organising Map which can learn similarities between object trajectories in an unsupervised manner. Encoding trajectories in this way leads to efficiency gains over existing approaches that use discrete point-based flow vectors to represent the whole trajectory. Assuming the clusters of trajectory points are distributed normally in the coefficient feature space, we propose a simple Mahalanobis classifier for the detection of anomalous trajectories. Our proposed techniques are validated on three different datasets - Australian sign language, handlabelled object trajectories from video surveillance footage and real-time tracking data obtained in the laboratory. Applications to event detection and motion data mining for visual surveillance systems are envisaged.
Real-time vehicle tracking system (2015)

This thesis report is submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Electrical and Electronic Engineering, 2015.
Technical note: A deformable phantom for dynamic modeling in radiation therapy (2006)

A deformable phantom was developed to aid in quality assurance for dynamic imaging and targeting techniques in radiation therapy. Made of simple materials combined with standard components for imaging and motion experiments, this phantom can be relatively easily constructed and used for both diagnostic imaging and dosimetry. Repeat imaging studies indicate that the phantom meets criteria of relative attenuation, deformation, and reproducibility of configuration, necessary for quality assurance of radiographic and tomographic targeting.
Precision manufacturing for clinical-quality regenerative medicines (2012)

Innovations in engineering applied to healthcare make a significant difference to people's lives. Market growth is guaranteed by demographics. Regulation and requirements for good manufacturing practice-extreme levels of repeatability and reliability-demand high-precision process and measurement solutions. Emerging technologies using living biological materials add complexity. This paper presents some results of work demonstrating the precision automated manufacture of living materials, particularly the expansion of populations of human stem cells for therapeutic use as regenerative medicines. The paper also describes quality engineering techniques for precision process design and improvement, and identifies the requirements for manufacturing technology and measurement systems evolution for such therapies.
Monodisperse α<i>-</i>Fe<sub>2</sub>O<sub>3</sub>@SiO<sub>2</sub>@Au core/shell nanocomposite spheres: synthesis, characterization and properties (2008)

A new hybrid spherical structure α-Fe(2)O(3)@SiO(2)@Au with a size of about 141 nm was designed, with a hematite cubic core surrounded by a thick silica shell and further decorated with gold nanoparticles. The monodisperse α-Fe(2)O(3)@SiO(2) spheres were first prepared by a sol-gel process based on the modified Stöber method. Subsequently, the surface of the α-Fe(2)O(3)@SiO(2) particles was functionalized by-NH(2) functional groups. The electrostatic attraction of -NH(2) groups will attach the negatively charged Au nanoparticles to the amino-functionalized α-Fe(2)O(3)@SiO(2) nanospheres in order to prepare α-Fe(2)O(3)@SiO(2) monodisperse hybrid spheres. The M(H) hysteresis loop for α-Fe(2)O(3)@SiO(2) and α-Fe(2)O(3)@SiO(2)@Au spheres indicates that the nanocomposite spheres exhibit superparamagnetic characteristics at room temperature. The optical properties and the application of these hybrid nanocomposites as catalysts for the conversion of CO to CO(2) have also been studied.
Lipid transfer proteins (1984)

Lipid transfer proteins were discovered in our labe ratory as a result of studies that began with the question: How are lipid components of plasma lipoproteins taken up by the liver cell? It soon became apparent that these cells contained a cytosolic factor ( I ) , which transferred PC from one membrane to another. Upon demonstrating that the factor was nondialyzable, heat-labile, and sensitive to trypsin, the factor was assumed to be a protein. In as much as the factor accelerated the transfer of PC between microsomes and mitochondria to approximately equal extents, the protein was named phospholipid exchange protein (2). Similar observations soon followed from other laboratories. In addition, the systematic efforts to purify the exchange protein uncovered the presence of a variety of proteins that could accelerate the transfer of different phospholipid classes and the less polar lipids as well. Moreover, under the proper conditions, the proteins were shown to mediate net transfer reactions as well as equimolar lipid exchanges. Hence, by agreement between the major groups working in this area, the designation of these proteins was changed to “lipid transfer proteins” for generic usage. The more specific designations, for example, would then be “PC-specific transfer protein”, abbreviated as PC-TP and “nonspecific transfer protein”, abbreviated ns-TP. Most of the transfer proteins discovered thus far have been identified as cytosolic proteins in various tissues of animals and plants. One cannot exclude the possibility, however, that the proteins were originally membraneassociated, but were released by the homogenization procedure. Such an occurrence has been observed for a lipid transfer protein, which appears to be associated largely with the microsomal fraction, but that can be released by the treatment of microsomes with low ionic strength buffers (3). Even during the homogenization of liver with 250 mM sucrose, 50 mM Tris, 1 mM EDTA, some of this transfer activity is found in cytosol, but was probably microsomal in origin. One other class of lipid transfer proteins is found in blood plasma of some animal species (4, 5), including human plasma (6-14). These proteins may be rather nonspecific (I 5) or may accelerate the transfer of phospholipid preferentially (1 6, 17). In subsequent sections I intend to review the distribution of lipid transfer proteins, how these proteins have been utilized to study lipid asymmetry in biological and in artificial membranes, and the effect of membrane lipid modification on enzyme activities. Some of these aspects of lipid transfer protein biochemistry have also been reviewed recently (1 8). Methodologies of assays, as well as other topics, have been discussed by Zilversmit and Hughes (1 9), Wirtz (20), Wetterau and Zilversmit (21), Akeroyd and Wirtz (22), Kader (25, 24), Bloj and Zilversmit (25, 26), Bergelson and Barsukov (27), and Rothman and Lenard (28). From these reviews it is evident that many varieties of lipid transfer proteins have been discovered in animal and plant cells and a more limited number in unicellular organisms.
Design and Implementation of an Active RFID MAC Protocol (2007)

Active RFID can be well used in identifying, tracking and recording objects. Proper MAC protocol is needed for channel access and tag communication schedule. This paper presents a hybrid TDMA MAC protocol comprising of two component protocols - a contention protocol that provides effective operation under high density condition, and a TDMA allocation protocol that manages stable communication between reader and tags. Analysis shows that such protocol also provides well energy conserving. We also design an active RFID system platform suitable for such MAC protocol and other applications.
PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIFUNGAL INVESTIGATION OF PARTHENIUM HYSTEROPHORUS EXTRACTS AGAINST ALTERNARIA ALTERNATA (2013)

The extensive use of fungicides are polluting the environment and giving rise to undesirable biological effects on animal and human beings. Therefore use of plant extracts as biological control agents is being popularized in recent years. Alternaria alternata is reported for causing foliage disease in several important vegetables and crops. In an approach towards the development of eco friendly antifungal compound for controlling plant diseases caused by Alternaria alternata different extracts of Parthenium hysterophorus were tested for their antifungal potential. Parthenium hysterophorus is considered as an obnoxious weed, growing on waste land. The four different solvent extracts viz., aqueous, methanol, acetone and ethanol extracts of leaves of Parthenium hysterophorus was evaluated from antifungal potential against four different isolates of Alternaria alternata isolated from potato (Solanum tuberosum), onion (Allium cepa), tomato (Lycopersicon esculentum) and mustard (Brassica compestris) by food poison technique. The ethanolic extract showed complete inhibition against the four isolates i.e. 100 % followed by acetone and methanol extracts which was approximately 96 % and 76 % respectively, while aqueous extract do not showed any antifungal activity. Thus the result showed that the ethanolic extract was the best extract to be used. The phytochemical analysis revealed the presence of alkaloid, glycoside, steroid, saponin in varying concentration in different extracts which might be the cause of antifungal potential. The present study supports the use of leaf extract of Parthenium hysterophorus as biofungicides for the disease caused by Alternaria alternata. This will help to save the environment from chemical hazards as most of the synthetic fungicide constitute mercury, zinc etc which are toxic for nature.
ROI Pooled Correlation Filters for Visual Tracking (2019)

The ROI (region-of-interest) based pooling method performs pooling operations on the cropped ROI regions for various samples and has shown great success in the object detection methods. It compresses the model size while preserving the localization accuracy, thus it is useful in the visual tracking field. Though being effective, the ROI-based pooling operation is not yet considered in the correlation filter formula. In this paper, we propose a novel ROI pooled correlation filter (RPCF) algorithm for robust visual tracking. Through mathematical derivations, we show that the ROI-based pooling can be equivalently achieved by enforcing additional constraints on the learned filter weights, which makes the ROI-based pooling feasible on the virtual circular samples. Besides, we develop an efficient joint training formula for the proposed correlation filter algorithm, and derive the Fourier solvers for efficient model training. Finally, we evaluate our RPCF tracker on OTB-2013, OTB-2015 and VOT-2017 benchmark datasets. Experimental results show that our tracker performs favourably against other state-of-the-art trackers.
Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers (2011)

M-CSF favors the generation of folate receptor β-positive (FRβ⁺), IL-10-producing, immunosuppressive, M2-polarized macrophages [M2 (M-CSF)], whereas GM-CSF promotes a proinflammatory, M1-polarized phenotype [M1 (GM-CSF)]. In the present study, we found that activin A was preferentially released by M1 (GM-CSF) macrophages, impaired the acquisition of FRβ and other M2 (M-CSF)-specific markers, down-modulated the LPS-induced release of IL-10, and mediated the tumor cell growth-inhibitory activity of M1 (GM-CSF) macrophages, in which Smad2/3 is constitutively phosphorylated. The contribution of activin A to M1 (GM-CSF) macrophage polarization was evidenced by the capacity of a blocking anti-activin A antibody to reduce M1 (GM-CSF) polarization markers expression while enhancing FRβ and other M2 (M-CSF) markers mRNA levels. Moreover, an inhibitor of activin receptor-like kinase 4/5/7 (ALK4/5/7 or SB431542) promoted M2 (M-CSF) marker expression but limited the acquisition of M1 (GM-CSF) polarization markers, suggesting a role for Smad2/3 activation in macrophage polarization. In agreement with these results, expression of activin A and M2 (M-CSF)-specific markers was oppositely regulated by tumor ascites. Therefore, activin A contributes to the proinflammatory macrophage polarization triggered by GM-CSF and limits the acquisition of the anti-inflammatory phenotype in a Smad2-dependent manner. Our results demonstrate that activin A-initiated Smad signaling skews macrophage polarization toward the acquisition of a proinflammatory phenotype.
Preliminary Findings from a Prospective, Randomized Trial of Two Tongue‐Base Surgeries for Sleep‐Disordered Breathing (2003)

Prospective, randomized trials of tongue-base surgery for sleep-disordered breathing are possible. Preliminary findings from the current protocol reveal a slight advantage of tongue suspension over tongue advancement.
Modification of pulse position modulation for high data UWB systems and multi-user communication (2004)

This paper proposes a concatenated single-pulse modulation (C-PPM) for UWB systems by increasing the number of pulses in time symbol interval. Further adaptation of orthogonal codes to bipolar signal PPM is studied. The results obtained considered the possible application for high data transmission systems and multi-user environments.
Español antiguo frente a castellano antiguo: Reflexiones dialectológicas (2000)

It is not necessary to support inferior retinal breaks with a scleral explant during PPV for primary RD repair in selected cases.
Performance Analysis of Dual-Homed Fault-Tolerant Routing in Wireless Sensor Networks (2008)

One of the fundamental purpose of sensing information is to immediately respond to any anomalies. In order to make an accurate and cognizant decision, there is a great need for a fault-tolerant wireless sensor network. In this paper, we evaluate two categories of dual-homed routing for providing fault-tolerance in wireless sensor networks, namely dedicated dual-homed routing and shared dual-homed routing. We investigate two dedicated dual-homed routing techniques, namely 1+1 dual-homed routing and 1:1 dual-homed routing. We also develop shared dual-homed routing techniques, namely 1:2 dual-homed routing and 1:4 dual-homed routing. This paper investigates each technique's capability for providing fault-tolerance and its performance in terms of network lifetime, packet loss probability, end-to-end packet delay, and average throughput. Such an investigation will provide a comprehensive understanding about each proposed fault-tolerant technique. This will provide valuable insight for providing grade-of-protection in multi-layer wireless sensor networks by applying different techniques at different layers.
Field-Effect Transistors Based on Few-Layered α-MoTe<sub>2</sub> (2014)

Here we report the properties of field-effect transistors based on a few layers of chemical vapor transport grown α-MoTe2 crystals mechanically exfoliated onto SiO2. We performed field-effect and Hall mobility measurements, as well as Raman scattering and transmission electron microscopy. In contrast to both MoS2 and MoSe2, our MoTe2 field-effect transistors are observed to be hole-doped, displaying on/off ratios surpassing 10(6) and typical subthreshold swings of ∼140 mV per decade. Both field-effect and Hall mobilities indicate maximum values approaching or surpassing 10 cm(2)/(V s), which are comparable to figures previously reported for single or bilayered MoS2 and/or for MoSe2 exfoliated onto SiO2 at room temperature and without the use of dielectric engineering. Raman scattering reveals sharp modes in agreement with previous reports, whose frequencies are found to display little or no dependence on the number of layers. Given that MoS2 is electron-doped, the stacking of MoTe2 onto MoS2 could produce ambipolar field-effect transistors and a gap modulation. Although the overall electronic performance of MoTe2 is comparable to those of MoS2 and MoSe2, the heavier element Te leads to a stronger spin-orbit coupling and possibly to concomitantly longer decoherence times for exciton valley and spin indexes.
Complex-mediated microwave-assisted synthesis of polyacrylonitrile nanoparticles (2010)

The polymerization of acrylonitrile (AN) is efficiently, easily, and quickly achieved in the presence of trans-[Co(III)en2Cl2]Cl complex in a domestic microwave (MW) oven. MW irradiation notably promoted the polymerization reaction; this phenomenon is ascribed to the acceleration of the initiator, ammonium persulfate (APS), decomposition by microwave irradiation in the presence of [Co(III)en2Cl2]Cl. The conversion of monomer to the polymer was mostly excellent in gram scale. Irradiation at low power and time produced more homogeneous polymers with high molecular weight and low polydispersity when compared with the polymer formed by a conventional heating method. The interaction of reacting components was monitored by UV-visible spectrometer. The average molecular weight was derived by gel permeation chromatography (GPC), viscosity methods, and sound velocity by ultrasonic interferometer. The uniform and reduced molecular size was characterized by transmission electron microscopy, the diameter of polyacrylonitrile nanoparticles (PAN) being in the range 50-115 nm and 40-230 nm in microwave and conventional heating methods respectively. The surface morphology of PAN prepared by MW irradiation was characterized by scanning electron microscope (SEM). From the kinetic results, the rate of polymerization (Rp) was expressed as Rp = [AN](0.63) [APS](0.57) [complex (I)].(0.88.)
Anti-Staphylococcus aureus and Anti-yeast activity of Streptomyces species isolated from rhizosphere soil of Sahyadri Science College, Shivamogga, Karnataka (2013)

The present study was undertaken to investigate Anti-Staphylococcus aureus and Anti-yeast activity of ethyl acetate extracts from six Streptomyces species (SSC-MB-01 to SSC-MB-06) isolated previously from rhizosphere soil of Sahyadri Science College campus, Shivamogga. Antibacterial activity was performed by agar well diffusion assay against four isolates of Staphylococcus aureus (resistant to methicillin) recovered previously from burn patients. Anti-yeast activity was checked against two yeasts viz., Candida albicans and Cryptococcus neoformans by agar well diffusion assay. Extracts of all Streptomyces species have shown inhibition of yeasts and clinical isolates of S. aureus. Among six isolates, SSC-MB-04 caused highest inhibition of S. aureus isolates. Among yeasts, higher susceptibility was recorded in case of C. neoformans. The Streptomyces species from the campus soil have shown to be promising against S. aureus and human pathogenic yeasts. Further studies on separation of bioactive principles from the extracts and determination of their bioactivities are under progress.
Advances in Organ Transplant (2017)

Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source. Organs that have been successfully transplanted include the heart, kidneys, liver, lungs, pancreas, intestine, and thymus. Some organs, like the brain, cannot be transplanted. Tissues include bones, tendons (both referred to as musculoskeletal grafts), corneae, skin, heart valves, nerves and veins. Worldwide, the kidneys are the most commonly transplanted organs, followed by the liver and then the heart. Corneae and musculoskeletal grafts are the most commonly transplanted tissues; these outnumber organ transplants by more than tenfold. 


	In the present book, fifteen typical literatures about Organ Transplant published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on transplantation, medical science, clinical trial, ect. We hope this book can demonstrate advances in Organ Transplant as well as give references to the researchers, students and other related people.
Cytosolic ionized Ca<sup>2+</sup>modulates chemical hypoxia-induced hyperpermeability in intestinal epithelial monolayers (1998)

We reported previously that ATP depletion induced by glycolytic inhibition or cellular hypoxia increases the permeability of intestinal epithelial monolayers [N. Unno, M. J. Menconi, A. L. Salzman, M. Smith, S. Hagen, Y. Ge, R. M. Ezzell, and M. P. Fink. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G1010-G1021, 1996]. In the present study, we examined the effects of the Ca2+ ionophore A-23187 or the intracellular ionized Ca2+ concentration ([Ca2+]i) chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA)-AM on the permeability of enterocytic (T84) monolayers depleted of ATP by metabolic inhibition. Permeability was assessed by measuring transepithelial electrical resistance and the transepithelial flux of fluorescein sulfonic acid. Although neither A-23187 nor BAPTA-AM affected ATP depletion, A-23187 augmented, whereas BAPTA-AM ameliorated, chemical hypoxia-induced hyperpermeability. BAPTA-AM ameliorated chemical hypoxia-induced cytoskeletal derangements. Monolayers subjected to chemical hypoxia but incubated in a low (i.e., 100 microM) [Ca2+] environment showed preservation of junctional integrity, whereas voltage-dependent Ca2+ channel blockers (NiCl2 or verapamil) failed to ameliorate chemical hypoxia-induced hyperpermeability. ATP depletion induces hyperpermeability in intestinal epithelial monolayers via a [Ca2+]i-dependent mechanism. Increased [Ca2+]i under these conditions reflects leakage of Ca2+ from the extracellular milieu via a mechanism unrelated to voltage-dependent Ca2+ channels.