gebhart/patrepeval huggingface dataset:
177Lu-EC0800 Combined with the Antifolate Pemetrexed: Preclinical Pilot Study of Folate Receptor Targeted Radionuclide Tumor Therapy (2013)

Targeted radionuclide therapy has shown impressive results for the palliative treatment of several types of cancer diseases. The folate receptor has been identified as specifically associated with a variety of frequent tumor types. Therefore, it is an attractive target for the development of new radionuclide therapies using folate-based radioconjugates. Previously, we found that pemetrexed (PMX) has a favorable effect in reducing undesired renal uptake of radiofolates. Moreover, PMX also acts as a chemotherapeutic and radiosensitizing agent on tumors. Thus, the aim of our study was to investigate the combined application of PMX and the therapeutic radiofolate (177)Lu-EC0800. Determination of the combination index (CI) revealed a synergistic inhibitory effect of (177)Lu-EC0800 and PMX on the viability of folate receptor-positive cervical (KB) and ovarian (IGROV-1) cancer cells in vitro (CI < 0.8). In an in vivo study, tumor-bearing mice were treated with (177)Lu-EC0800 (20 MBq) and a subtherapeutic (0.4 mg) or therapeutic amount (1.6 mg) of PMX. Application of (177)Lu-EC0800 with PMXther resulted in a two- to four-fold enhanced tumor growth delay and a prolonged survival of KB and IGROV-1 tumor-bearing mice, as compared to the combination with PMXsubther or untreated control mice. PMXsubther protected the kidneys from undesired side effects of (177)Lu-EC0800 (20 MBq) by reducing the absorbed radiation dose. Intact kidney function was shown by determination of plasma parameters and quantitative single-photon emission computed tomography using (99m)Tc-DMSA. Our results confirmed the anticipated dual role of PMX. Its unique features resulted in an improved antitumor effect of folate-based radionuclide therapy and prevented undesired radio-nephrotoxicity.
Expected Noise Levels For Interferometric Sensors Multiplexed Using Partially Coherent Light (1986)

A method for multiplexing interferometric optical sensors is reviewed, and theoretical results are presented which predict the phase sensitivity of sensors multiplexed using this method. The multiplexing technique--"coherence multiplexing' is based on the use of a source whose coherence length is short compared to most system optical path length differences. The use of a single-mode semiconductor laser diode source typically leads to a min-imum detectable phase on the order of a milliradian per VHz. Small improvements result from the use of a noise-canceling balanced detection scheme. Sensitivity in the microradian per VHz regime might be achieved through the use of a shorter coherence length source such as a superluminescent diode.
The Transuranium Elements (1956)

2. The actinide element concept.The intensive study of the heaviest elements in the l a s t few y e a r s including the synthesis and study of t r a n s u r a n i u m e l e m e n t s up to atomic number 101 has m a d e i t c e r t a i n that, considering the s e r i e s a s a whole, the 5f s e r i e s of elements begins a t actinium in the s a m e s e n s e that the r d r e -e a r i h s e r i e s begins with lanthanum.
Enhanced non-vitreous cryopreservation of immortalized and primary cells by ice-growth inhibiting polymers (2016)

Cell cryopreservation is an essential tool in modern biotechnology and medicine. The ability to freeze, store and distribute materials underpins basic cell biology and enables storage of donor cells needed for transplantation and regenerative medicine. However, many cell types do not survive freezing and the current state-of-the-art involves the addition of significant amounts of organic solvents as cryoprotectants, which themselves can be cytotoxic, or simply interfere with assays. A key cause of cell death in cryopreservation is ice recrystallization (growth), which primarily occurs during thawing. Here it is demonstrated that the addition of ice recrystalization inhibiting polymers to solutions containing low (non vitrifying) concentrations of DMSO enhance cell recovery rates by up to 75%. Cell functionality is also demonstrated using a placental cell line, and enhanced cryopreservation of primary rat hepatocytes is additionally shown. The crucial role of the polymers architecture (chain length) is shown, with shorter polymers being more effective than longer ones.
The Alkaloids of Tabernanthe iboga. Part III.<sup>1</sup> Isolation Studies (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Alkaloids of Tabernanthe iboga. Part III.1 Isolation StudiesD. F. Dickel, C. L. Holden, R. C. Maxfield, L. E. Paszek, and W. I. TaylorCite this: J. Am. Chem. Soc. 1958, 80, 1, 123–125Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://pubs.acs.org/doi/10.1021/ja01534a035https://doi.org/10.1021/ja01534a035research-articleACS PublicationsRequest reuse permissionsArticle Views357Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Computer controlled cw laser spectrometer (1979)

A computer controlled cw UV-visible dye laser source for spectroscopic use has been developed. Computer control facilitates both continuous single-frequency scanning and data acquisition. With 4 W of Ar-ion laser pump power, such a spectrometer can generate in excess of 1 W of cw single-frequency power in the visible and up to 1 mW in the UV by using extracavity nonlinear optical mixing. The laser spectrometer has been tested by performing high-resolution measurements of the fluorescence spectrum of I(2) in the visible and of the absorption spectrum of SO(2) in the UV.
Cost Analysis for Flat-Plate Concentrators Employing Microscale Photovoltaic Cells. (2016)

Abstract not provided.
Increased histamine in plasma and tissues in diabetic rats. (1988)

In view of the previous observation that the histamine content of the aorta in rats with streptozotocin-induced diabetes mellitus is increased significantly over that in controls, we have investigated the effect of experimental diabetes on the histamine content of the plasma, the aorta, the kidney, the heart, the lung and the brain. Our data show that the histamine content of the plasma, the aorta, the heart, the kidney, the lung and the brain is significantly greater in diabetic rats than that found in controls. This increase in plasma and tissue histamine content may contribute to the increase in capillary and endothelial permeability known to occur in diabetes, and may have a role to play in the pathogenesis of diabetic micro- and macroangiopathy.
A unified optimization approach for a (6+1)-axis robot system (2002)

A (6+1)-axis robot consists of a 6-joint GMF S-700 regular robot arm moving on a linear servo-track that is specifically designed for auto-industrial advanced applications. Kinematically, it is modeled as a seven-joint redundant robot with a one-dimensional null space. A new algorithm of the inverse kinematic solution is developed to provide a unified approach to the realization of major local optimization methods. The (6+1)-axis robot has been implemented in GM laboratory to enhance flexibility and effectiveness of the existing ROBOCUT system for full-size car-model cutting as well as car-body painting.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
古希腊探秘：荷马的《奥德赛》 (2009)

相信大家对希腊神话一定不陌生：凄美动人的爱情故事、壮美雄阔的战争场景……希腊神话是希腊人将世界理想化、把社会诗歌化、把人生艺术化的艺术表现，不但奠定了日后希腊文明的基础，也是西方文学艺术作品几千年来的灵感之源，是研究西方文艺的必经之路。希腊神话和传说中最有名的故事有特洛伊战争、奥德修斯的游历、伊阿宋寻找金羊毛、赫拉克勒斯的功绩、忒修斯的冒险和俄狄浦斯的悲剧等。现在，就让我们来听听奥德修斯的故事—
Sequence Based Prediction of Antioxidant Proteins Using a Classifier Selection Strategy (2016)

Antioxidant proteins perform significant functions in maintaining oxidation/antioxidation balance and have potential therapies for some diseases. Accurate identification of antioxidant proteins could contribute to revealing physiological processes of oxidation/antioxidation balance and developing novel antioxidation-based drugs. In this study, an ensemble method is presented to predict antioxidant proteins with hybrid features, incorporating SSI (Secondary Structure Information), PSSM (Position Specific Scoring Matrix), RSA (Relative Solvent Accessibility), and CTD (Composition, Transition, Distribution). The prediction results of the ensemble predictor are determined by an average of prediction results of multiple base classifiers. Based on a classifier selection strategy, we obtain an optimal ensemble classifier composed of RF (Random Forest), SMO (Sequential Minimal Optimization), NNA (Nearest Neighbor Algorithm), and J48 with an accuracy of 0.925. A Relief combined with IFS (Incremental Feature Selection) method is adopted to obtain optimal features from hybrid features. With the optimal features, the ensemble method achieves improved performance with a sensitivity of 0.95, a specificity of 0.93, an accuracy of 0.94, and an MCC (Matthew's Correlation Coefficient) of 0.880, far better than the existing method. To evaluate the prediction performance objectively, the proposed method is compared with existing methods on the same independent testing dataset. Encouragingly, our method performs better than previous studies. In addition, our method achieves more balanced performance with a sensitivity of 0.878 and a specificity of 0.860. These results suggest that the proposed ensemble method can be a potential candidate for antioxidant protein prediction. For public access, we develop a user-friendly web server for antioxidant protein identification that is freely accessible at http://antioxidant.weka.cc.
General patterns for nonmonotonic reasoning: from basic entailments to plausible relations (2000)

This paper has two goals. First, we develop frameworks for logical systems which are able to reflect not only non-monotonic patterns of reasoning, but also paraconsistent reasoning. Our second goal is to have a better understanding of the conditions that a useful relation for nonmonotonic reasoning should satisfy. For this we consider a sequence of generalizations of the pioneering works of Gabbay, Kraus, Lehmann, Magidor and Makinson. These generalizations allow the use of monotonic nonclassical logics as the underlying logic upon which nonmonotonic reasoning may be based. Our sequence of frameworks culminates in what we call (following Lehmann) plausible, nonmonotonic, multiple-conclusion consequences relations (which are based on a given monotonic one). Our study yields intuitive justifications for conditions that have been proposed in previous frameworks and also clarifies the connections among some of these systems. In addition, we present a general method for constructing plausible nonmonotonic relations. This method is based on a multiple-valued semantics, and on Shoham's idea of preferential models.
Structural Basis for Substrate Recognition in the Salicylic Acid Carboxyl Methyltransferase Family (2003)

Recently, a novel family of methyltransferases was identified in plants. Some members of this newly discovered and recently characterized methyltransferase family catalyze the formation of small-molecule methyl esters using S-adenosyl-L-Met (SAM) as a methyl donor and carboxylic acid-bearing substrates as methyl acceptors. These enzymes include SAMT (SAM:salicylic acid carboxyl methyltransferase), BAMT (SAM:benzoic acid carboxyl methyltransferase), and JMT (SAM:jasmonic acid carboxyl methyltransferase). Moreover, other members of this family of plant methyltransferases have been found to catalyze the N-methylation of caffeine precursors. The 3.0-A crystal structure of Clarkia breweri SAMT in complex with the substrate salicylic acid and the demethylated product S-adenosyl-L-homocysteine reveals a protein structure that possesses a helical active site capping domain and a unique dimerization interface. In addition, the chemical determinants responsible for the selection of salicylic acid demonstrate the structural basis for facile variations of substrate selectivity among functionally characterized plant carboxyl-directed and nitrogen-directed methyltransferases and a growing set of related proteins that have yet to be examined biochemically. Using the three-dimensional structure of SAMT as a guide, we examined the substrate specificity of SAMT by site-directed mutagenesis and activity assays against 12 carboxyl-containing small molecules. Moreover, the utility of structural information for the functional characterization of this large family of plant methyltransferases was demonstrated by the discovery of an Arabidopsis methyltransferase that is specific for the carboxyl-bearing phytohormone indole-3-acetic acid.
Communication costs in code and design reviews: an empirical study (1996)

Software development managers strive to control all of the factors that might impact the success of their projects. However, not all of these factors have been identified, much less understood enough to be controlled or manipulated. One important but poorly understood factor is communication between developers. This paper presents results from an exploratory study which aimed to identify some of the characteristics which affect communication costs in software development, and to begin to understand those effects. Communication patterns were observed during code and design reviews. At the same time, data were gathered about organizational and other contextual factors. A number of well-grounded hypotheses were generated from the data collected. One such hypothesis, which was strongly suggested by the data, is the subject of this paper. It states that groups require more effort to communicate when they include a few (but not too many) members who are organizationally distant from the others, and less effort is required when the group is composed of all or nearly all organizationally distant members. In this paper, we describe the data that supports this hypothesis as well as those that dispute it, and argue for its continued study.
Target talker enhancement in hearing devices (2008)

We describe a novel coherent modulation filtering technique for single channel target talker enhancement in the presence of interfering talkers. For this technique, we have expanded our previous work on coherent modulation filtering with a carrier estimator that is more robust to speech from interfering talkers, and a modulation filter that operates on shorter time-scales. We have evaluated the technique in a subjective listening test, which indicates that the novel target talker enhancement technique achieves a moderate improvement in speech reception. We summarize our observations on single channel target talker enhancement and conclude with directions for further research.
Copper(II) hemocyanin models (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopper(II) hemocyanin modelsVickie McKee, Jeffrey V. Dagdigian, Robert Bau, and Christopher A. ReedCite this: J. Am. Chem. Soc. 1981, 103, 23, 7000–7001Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/ja00413a054https://doi.org/10.1021/ja00413a054research-articleACS PublicationsRequest reuse permissionsArticle Views544Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activity (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT9-(2-Fluorobenzyl)-6-(methylamino)-9H-purine hydrochloride. Synthesis and anticonvulsant activityJames L. Kelley and Francis E. SorokoCite this: J. Med. Chem. 1986, 29, 7, 1133–1134Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/jm00157a003https://doi.org/10.1021/jm00157a003research-articleACS PublicationsRequest reuse permissionsArticle Views152Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages (1993)

CD14 has been reported to function as a receptor for bacterial LPS complexed with serum proteins, transducing an activation signal for TNF-alpha production. We found that the anti-CD14 mAb MEM-18 inhibited not only LPS-induced release of TNF-alpha, but also LPS-induced, TNF-alpha independent release of IL-6 and IL-8 by human monocytes and alveolar macrophages. Inhibitory effect of MEM-18 was detected both in the presence of human or bovine calf serum and under serum-free conditions. In contrast, MEM-18 did not block release of these cytokines induced by IL-1 beta, TNF-alpha, PMA, and zymosan. We conclude that CD14 is involved in LPS-induced release of TNF-alpha, IL-6, and IL-8 by monocytes and alveolar macrophages and that this receptor appears to be able to recognize LPS directly in the absence of serum.
Native Mass Spectrometry Imaging of Proteins and Protein Complexes by Nano-DESI (2021)

Previously, we have demonstrated native mass spectrometry imaging (native MSI) in which the spatial distribution of proteins maintained in their native-like, folded conformations was determined using liquid extraction surface analysis (LESA). While providing an excellent testbed for proof of principle, the spatial resolution of LESA is currently limited for imaging primarily by the physical size of the sampling pipette tip. Here, we report the adoption of nanospray-desorption electrospray ionization (nano-DESI) for native MSI, delivering substantial improvements in resolution versus native LESA MSI. In addition, native nano-DESI may be used for location-targeted top-down proteomics analysis directly from tissue. Proteins, including a homodimeric complex not previously detected by native MSI, were identified through a combination of collisional activation, high-resolution MS and proton transfer charge reduction.
A high-efficient LLCC series-parallel resonant converter (2010)

A high efficient LLCC-type resonant dc-dc converter is discussed in this paper for a low-power photovoltaic application. Emphasis is put on the different design mechanisms of the resonant tank. At the same time soft switching of the inverter as well as the rectifier bridge are regarded. Concerning the design rules, a new challenge is solved in designing a LLCC-converter with voltage-source output. Instead of the resonant elements, ratios of them, e.g. the ratio of inductances L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</inf> /L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</inf> is considered as design parameters first. Furthermore, the derived design rule for the transformer-inductor device fits directly into the overall LLCC-design. Due to the nature of transformers, i.e. the relation of the inductances L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</inf> /L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</inf> is only a function of geometry, this design parameter is directly considered by geometry. Experimental results demonstrate the high efficiency.
Enhanced glomerular procoagulant activity and fibrin deposition in rats with mercuric chloride-induced autoimmune nephritis. (1987)

The mechanism involved in glomerular fibrin deposition was investigated during mercuric chloride (HgCl2)-induced autoimmune glomerulonephritis in the Brown Norway rat. To ascertain whether the local hemostatic system was activated secondarily to the immunological conflict, the ability of glomerular lysates to induce coagulation in vitro was assessed in treated and control rats. Glomerular procoagulant activity (PCA) of HgCl2-injected rats was measured on day 12 (latent phase of the disease), day 20 (acme), and days 32 and 42 (recovery phase) after the first mercury injection. PCA rose 3-fold (p less than 0.02) at day 20 and then almost returned to control values. Proteinuria, PCA, and the incidence of glomerular fibrin deposits peaked concomitantly at day 20. Glomerular PCA was characterized as thromboplastin. The number of Ia positive cells detected by monoclonal OX-6 antibody was not different from the control number at any phase of the disease; the number of macrophages per glomerular section detected by electron microscopy at day 20 in HgCl2-injected rats was 1.80 +/- 0.60, versus 0.30 +/- 0.11 in the controls. No correlation was found between glomerular PCA and either the number of monocytes/macrophages or of Ia-positive cells present in the glomeruli. Since glomerular PCA was maximal at the onset of fibrin formation in the glomeruli and then decreased toward its basal level, and since the fibrin disappeared, it is concluded that increased production of thromboplastin by glomeruli, with activation of the extrinsic coagulation pathway, may contribute to intraglomerular fibrin deposition in HgCl2-induced glomerulonephritis.