gebhart/patrepeval huggingface dataset:
Daratumumab (DARA) in combination with carfilzomib, lenalidomide, and dexamethasone (KRd) in patients (pts) with newly diagnosed multiple myeloma (MMY1001): An open-label, phase 1b study. (2017)

8000 Background: DARA in combination with established standard of care regimens prolongs PFS, deepens responses, and demonstrates a favorable safety profile in relapsed or refractory multiple myeloma (MM). The tolerability and efficacy of DARA-KRd in newly diagnosed MM pts was examined. Methods: Newly diagnosed pts regardless of transplantation eligibility were enrolled. Pts received DARA 16 mg/kg QW for Cycles 1-2, Q2W for Cycles 3-6, and Q4W thereafter. All pts received the 1st dose of DARA split over 2 days. Carfilzomib (K) was administered on Days 1, 8 and 15 of each 28-day cycle (20 mg/m 2 on C1D1, 36 or 70 mg/m 2 subsequently based on tolerability of first dose) for ≤13 cycles or elective discontinuation for ASCT. Lenalidomide 25 mg was given on Days 1-21 and dexamethasone 20-40 mg per week. The primary endpoint was tolerability. Results: Twenty-two pts (median [range] age, 60 [34-74] y) were enrolled and received a median of 8 (1-10) treatment cycles. Nineteen pts escalated K dose to 70 mg/m 2 by C1D15. Median (range) duration of follow-up was 7.4 (4.0-9.3) months. Six (27%) pts discontinued treatment (1 AE [pulmonary embolism]; 1 PD; 4 other [ASCT]). Serious AEs occurred in 46% of pts, and 14% were possibly related to DARA; 18 (82%) experienced a grade 3/4 TEAE. The most common grade 3/4 TEAEs (>10%) were lymphopenia (50%) and neutropenia (23%); 1 (5%) cardiac grade 3 TEAE was observed (congestive heart failure) which resolved; pt quickly resumed study treatment with reduced K dose. No grade 5 TEAE was reported. All DARA-associated infusion reactions (27% of pts) were grade ≤2. Treatment with DARA-KRd yielded an ORR (≥partial response) of 100% (5% complete response, 86% ≥very good partial response) in 21 response-evaluable pts. The 6-month PFS rate was 100%. Conclusions: The addition of DARA to KRd was well tolerated; the overall safety profile was consistent with that previously reported for KRd, with no additional toxicity observed with the addition of DARA. Deep and durable responses were observed. These data support further investigation of DARA-KRd as a frontline treatment regimen. Updated data will be presented based on longer follow up. Clinical trial information: NCT01998971.
Morphology and Deformation Mechanisms and Tensile Properties of Tetrafunctional Multigraft Copolymers (2009)

Morphology and deformation mechanisms and tensile properties of tetrafunctional multigraft (MG) polystrene-g-polyisoprene (PS-g-PI) copolymers were investigated dependent on PS volume fraction and number of branch points. The combination of various methods such as TEM, real time synchrotron SAXS, rheo-optical FTIR, and tensile tests provides comprehensive information at different dimension levels. TEM and SAXS studies revealed that the number of branch points has no obvious influence on the microphase-separated morphology of tetrafunction MG copolymers with 16 wt % PS. But for tetrafunctional MG copolymers with 25 wt % PS, the size and integrity of PS microdomains decrease with increasing number of branch point. The deformation mechanisms of MG copolymers are highly related to the morphology. Dependent on the microphase-separated morphology and integrity of the PS phase, the strain-induced orientation of the PS phase is at different size scales. Polarized FT-IR spectra analysis reveals that, for all investigated MG copolymers, the PI phase shows strain-induced orientation along SD at molecular scale. The proportion of the PI block effectively bridging PS domains controls the tensile properties of the MG copolymers at high strain, while the stress−strain behavior in the low-mediate strain region is controlled by the continuity of PS microdomains. The special molecular architecture, which leads to the higher effective functionality of PS domains and the higher possibility for an individual PI backbone being tethered with a large number of PS domains, is proposed to be the origin of the superelasticity for MG copolymers.
Might the Masson trichrome stain be considered a useful method for categorizing experimental tendon lesions? (2015)

Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subjective, and therefore a reliable grading method would be an improvement. The main purpose of this study was to assess qualitatively the histological pattern of Masson trichrome stain in healthy and injured tendons; indeed, the known "paradox" of Masson staining was used to create an evaluation for the matrix of tendons, following experimental lesions and natural repair processes. A statistically significant difference of aniline-staining between healthy and lesioned tendons was observed. Overall, we think that the Masson staining might be regarded as an informative tool in discerning the collagen spatial arrangement and therefore the histological characteristics of tendons.
Mixed Ether Electrolytes for Secondary Lithium Batteries with Improved Low Temperature Performance (1986)

Tetrahydrofuran (THF): 2‐methyl‐tetrahydrofuran mixed solutions, despite their lower conductivity, have allowed significantly better low temperature performance in cells than have . 13C NMR data suggest that this may be related to the structurally disordered Li+‐solvates that exist in the mixed ether solutions. High cycling efficiencies for the Li electrode in solutions have been achieved by the use of 2Me‐F as an additive. A 5 Ah capacity cell has been cycled more than 100 times at 100% depth‐of‐discharge, with the cell capacity remaining at over 3 Ah at the 100th cycle.
Food cravings consume limited cognitive resources. (2008)

Using Tiffany's (1990) cognitive model of drug use and craving as a theoretical basis, the present experiments investigated whether cravings for food expend limited cognitive resources. Cognitive performance was assessed by simple reaction time (Experiment 1) and an established measure of working memory capacity, the operation span task (Experiment 2). In each experiment, female undergraduate students were randomly assigned to a craving or control condition. Participants in the craving condition abstained from eating chocolate for 24 hours prior to testing and performed the cognitive task in the presence of chocolate, a manipulation that successfully elicited chocolate cravings. In both experiments, there was no main effect of craving condition on cognition, but there was a significant interaction between condition and trait chocolate craving. In support of Tiffany's model, our results show that habitual food cravers direct limited cognitive resources to craving-related cues, at the cost of competing cognitive demands.
Paperless manufacturing for IC assembly (2003)

The ongoing paperless manufacturing programs in application-specific integrated circuit (ASIC) assembly operations are described. Drawbacks of paperwork and approaches to paperwork elimination are discussed. Two projects related to paperless manufacturing in ASIC assembly are presented: an automated marking system project, which minimized operator input during product marking operation, and an electronic specification system project, which facilitated point-of-use specification retrieval. Some aspects of an integrated shop floor control system that addresses process control and lot tracking issues are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Determinants of hotel employment in Hong kong (2001)

This study of 32 hotels in Hong Kong investigated the importance that human-resources managers accord to economic and social factors that drivehotel employment levels, as well as looked at employees' personal attributes that may influence hiring. Senior managers place a strong emphasis on firm-specific factors such as occupancy rate, revenue, and service standards. More general industry-specific factors were perceived to be relatively less important in managers' decisions on hiring levels, while non-industry-specific factors (including macroeconomic measures) had the least impact on hotel hiring levels. In terms of personal attributes, it was found that an employee's attitude was perceived to be the most important criterion in a manager's selection decision.
Virus-induced silencing of sterol biosynthetic genes: identification of a Nicotiana tabacum L. obtusifoliol-14 -demethylase (CYP51) by genetic manipulation of the sterol biosynthetic pathway in Nicotiana benthamiana L. (2003)

Obtusifoliol-14alpha-demethylase (CYP51) is implicated in plant sterol biosynthesis. An Arabidopsis expressed sequence tag encoding a CYP51 was used as a probe to isolate Nicotiana tabacum L. cDNAs. Two types of cDNA clones were identified. Nt CYP51-1 and Nt CYP51-2 shared 97% identity together and around 75% with other plant CYP51s. The function of the encoded enzyme has been demonstrated in planta by manipulating the sterol biosynthetic pathway at the gene level. The endogenous CYP51 of Nicotiana benthamiana was silenced upon inoculation of the plantlets with POTATO VIRUS X::Nt CYP51-1 transcripts. This resulted in the accumulation of obtusifoliol, the substrate of CYP51, and other 14alpha-methyl sterols, with a concomitant growth reduction phenotype. Virus-induced gene silencing was also applied to another steroidogenic enzyme, the Delta7-sterol-C5(6)-desaturase, and this resulted in the accumulation of Delta7-sterols in infected plants instead of the pathway end-products Delta5-sterols.
Laser applications to arteriosclerosis: Angioplasty, angioscopy, and open endarterectomy (1985)

We have studied laser radiation of arteriosclerotic cardiovascular disease to determine the best technique for evaluation. Rabbits with arteriosclerosis were treated by intraluminal laser angioplasty (N = 8), laser angioscopy (N = 2), and open laser endarterectomy (N = 5). All studies were performed with an argon ion laser delivering energy through a 400-microns quartz fiber. Power delivered was varied in order to determine the best value for this animal model. Following angioplasty, perforation was seen in three rabbits (in one case, it was due to mechanical trauma from the fiber optic), and early thrombosis occurred in two rabbits. Plaques were vaporized by angioscopy, but the depth of laser beam penetration or angle of incidence could not be controlled. Open laser endarterectomy gave consistently good results with removal of an arteriosclerotic plaque within the media. The optimum power was found to be 1.0-2.0 W. Endarterectomy required an energy density of 100-140 J/cm2. We conclude that open laser endarterectomy can be a standardized technique for the in vivo evaluation of laser radiation upon arteriosclerotic lesions.
Towards guaranteed delivery of safety messages in VANETs (2012)

Reliability is a critical concern in disseminating safety messages in vehicular ad-hoc-networks (VANETs). Thus far, redundant broadcast (or next relay broadcast) has been used to ensure reliable transfer of safety messages. However, redundant broadcast fails to meet high-reliability requirement owing to lack of a feedback or acknowledgment (ACK) mechanism. In this work, a power controlled negative-acknowledgment (NACK) mechanism is introduced as a feedback technique to ensure reliable reception of safety messages. Significantly, this work also attempts to cover vehicles present in transmission holes in the broadcast region. Vehicles in the immediate neighborhood detect and recover safety message for a vehicle present in the transmission hole by estimating propagation loss for the vehicle. NACK together with hole detection and recovery mechanism nearly guarantees safety-message delivery in VANETs. Reliability of the proposed technique is formulated mathematically with packet reception ratio (PRR) as the reliability metric. Using theoretical analysis and simulation evaluation in ns-3 we establish that the proposed technique guarantees safety-message reception by mitigating packet loss caused by interference from hidden nodes, and at instances where vehicles are located in the transmission holes.
Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases. (2014)

Associations of angiotensin IV, diphthamide, and GM3 gangliosides with CD implicate novel pathways in activating a Th1/Th17 inflammatory profile. Increased QA concentrations in CD may indicate a defective auto-immunomodulation mechanism.
Lysophospholipid receptor nomenclature review: IUPHAR Review 8 (2014)

Lysophospholipids encompass a diverse range of small, membrane-derived phospholipids that act as extracellular signals. The signalling properties are mediated by 7-transmembrane GPCRs, constituent members of which have continued to be identified after their initial discovery in the mid-1990s. Here we briefly review this class of receptors, with a particular emphasis on their protein and gene nomenclatures that reflect their cognate ligands. There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). There are five sphingosine 1-phosphate (S1P) receptors: protein names S1P1 -S1P5 and italicized gene names S1PR1-S1PR5 (human) and S1pr1-S1pr5 (non-human). Recent additions to the lysophospholipid receptor family have resulted in the proposed names for a lysophosphatidyl inositol (LPI) receptor - protein name LPI1 and gene name LPIR1 (human) and Lpir1 (non-human) - and three lysophosphatidyl serine receptors - protein names LyPS1 , LyPS2 , LyPS3 and gene names LYPSR1-LYPSR3 (human) and Lypsr1-Lypsr3 (non-human) along with a variant form that does not appear to exist in humans that is provisionally named LyPS2L . This nomenclature incorporates previous recommendations from the International Union of Basic and Clinical Pharmacology, the Human Genome Organization, the Gene Nomenclature Committee, and the Mouse Genome Informatix.
Antitumor Effects of Proteasome Inhibition in Anaplastic Thyroid Carcinoma (2012)

On the basis of our data, bortezomib represents a promising antineoplastic agent for the treatment of ATC. To improve the clinical outcome, further investigation into the potential of bortezomib therapy of thyroid cancer is clearly warranted.
Structural and Optical Properties of Silver-Doped Zirconia and Mixed Zirconia−Silica Matrices Obtained by Sol−Gel Processing (1999)

The annealing behavior of zirconia and mixed zirconia−silica matrices (with different ZrO2/SiO2 molar ratios) containing silver nanoclusters, synthesized by the sol−gel technique has been investigated. The film samples of the general formula (SiO2)x(ZrO2)(0.9-x)Ag0.1 (x = 0, 0.225, 0.45, 0.675, and 0.9) were treated in different atmospheres (air, N2, and 5%H2−95%N2) at temperatures ranging from 200 to 900 °C. The ZrO2 matrix undergoes a structural phase transition from amorphous to cubic-tetragonal polycrystalline between 400 and 500 °C and on further raising the temperature near 600−700 °C the monoclinic phase also develops. On the contrary, the ZrO2:SiO2 system remains amorphous up to ∼700 °C. Ag nanoclusters are formed in all the systems. It has been observed that the change in the ZrO2/SiO2 molar ratio is an effective way to control not only the overall refractive index of the matrix but also the Ag cluster size. The shifting of the surface plasma resonance position of Ag nanoclusters is observed as a function of the refractive indices of the matrix following the Mie theory. Samples where characterized by transmission electron microscopy, Rutherford backscattering spectrometry, and optical spectrometry to correlate the cluster structure to their optical properties.
Electromagnetic inversion using quasi-linear approximation (2000)

Abstract Three-dimensional electromagnetic inversion continues to be a challenging problem in electrical exploration. We have recently developed a new approach to the solution of this problem based on quasi-linear approximation of a forward modeling operator. It generates a linear equation with respect to the modified conductivity tensor, which is proportional to the reflectivity tensor and the complex anomalous conductivity. We solved this linear equation by using the regularized conjugate gradient method. After determining a modified conductivity tensor, we used the electrical reflectivity tensor to evaluate the anomalous conductivity. Thus, the developed inversion scheme reduces the original nonlinear inverse problem to a set of linear inverse problems. The developed algorithm has been realized in computer code and tested on synthetic 3-D EM data. The case histories include interpretation of a 3-D magnetotelluric survey conducted in Hokkaido, Japan, and the 3-D inversion of the tensor controlled-source audio magnetotelluric data over the Sulphur Springs thermal area, Valles Caldera, New Mexico, U.S.A.
Photoluminescent Amphiphilic 1,4-Diketo-3,6-diphenylpyrrolo-[3,4-c]-pyrrole Derivative and Its Complexes with Polyelectrolytes (2002)

The new amphiphile 1,4-diketo-5-methyl-2-(11-undecyl sulfate sodium salt)-3-(4-chlor)phenyl-6-phenylpyrrolo-[3,4-c]-pyrrole (Na-1) is described, carrying the diketopyrrolopyrrole chromophore in the hydrophobic part. An aqueous solution of Na-1 exhibits an orange color with an absorption maximum at 475 nm and a red-orange fluorescence with a maximum at 529 nm. The critical micelle concentration in water is 4.1 × 10-5 mol/L. Highly concentrated aqueous solutions exhibit lyotropic phase behavior. Na-1 crystallizes into a lamellar structure. After heating to the melting point, the compound does not recrystallize upon cooling but forms a supercooled melt with a glass transition temperature. The combination of aqueous solutions of Na-1 and cationic polyelectrolytes in a stoichiometric ratio leads to the formation of polyelectrolyte−surfactant complexes with mesomorphous structure and a glass transition temperature depending on the structure of the polyelectrolyte. Complexes of Na-1 with poly(allylamine hydrochloride) and poly[(methylbutylimino)hexy-lene bromide] are characterized. The optical properties of the complexes are comparable with those of Na-1, while the solubility is clearly lower. Because of their convenient optical properties and their plasticity and resistance to solvents, the complexes represent interesting new materials with potential applications as coloring agents.
Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol (1993)

The translocation of protein kinase C (PKC) from the cytosolic to the particulate fraction in IIC9 fibroblasts has been studied to define the functions of 1,2-diacylglycerol (DAG) derived from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylcholine (PC). alpha-Thrombin caused a biphasic change in DAG, with two peaks at 15-60 s and 5-15 min, derived from PIP2 and PC, respectively, while platelet-derived growth factor (PDGF) induced a monophasic DAG increase from PC at 5-15 min. alpha-Thrombin also induced a rapid, but transient, increase of inositol 1,4,5-trisphosphate and cytosolic Ca2+, whereas PDGF did not. Three PKC isozymes, alpha, epsilon, and zeta, were identified by Western blotting in IIC9 cells and were mainly localized in the cytosol. A fraction of cytosolic PKC alpha was rapidly translocated by alpha-thrombin at 15 s, but its membrane association was lost within 1 min. PKC epsilon was also rapidly translocated; however, its membrane association was sustained for almost 60 min. PKC zeta was not translocated by alpha-thrombin or phorbol 12-myristate 13-acetate. PDGF translocated PKC epsilon at 5 min but had little effect at 15 s and did not translocate PKC alpha or zeta. Incubation with Bacillus cereus PC- or phosphatidylinositol-specific phospholipase C, which increased DAG but not phosphatidic acid, stimulated translocation of PKC epsilon, but not PKC alpha or zeta. Addition of chelators to inhibit the rise in intracellular Ca2+ largely blocked PKC alpha translocation induced by alpha-thrombin but had no effect on PKC epsilon translocation. Addition of ionomycin allowed alpha-thrombin to induce PKC alpha translocation at 5 min. PKC alpha translocation was mimicked by 1,2-dioctanoylglycerol plus ionomycin, but not by either alone. On the other hand, PKC epsilon was translocated by the DAG alone. These results support the conclusion that PIP2 hydrolysis activates both PKC alpha and epsilon at 15 s, whereas PC hydrolysis activates only PKC epsilon at 5 min. The differential activation at 5 min can be attributed to the failure of PC hydrolysis to increase Ca2+ and not to a difference in the molecular species of DAG derived from the phospholipids.
Changes in glutathione concentration in hypothermically perfused dog kidneys. (1991)

A loss of glutathione from the kidney can cause increased sensitivity to oxygen free radical-induced injury. In this study we investigated the effects of kidney preservation on glutathione and how various glutathione precursors affect glutathione concentration in the dog kidney. During 5-day continuous machine perfusion of the kidney at 5 degrees C, a loss of glutathione from the cortex tissue was seen (24% +/- 1% glutathione remained after 5 days). Perfusion with reduced glutathione (GSH, 3 mmol/L) suppressed this loss (77% +/- 11% of glutathione remained after 5 days). Oxidized glutathione (GSSG) did not prevent the loss of glutathione. The addition of the three amino acids that make up glutathione (glycine, glutamic acid, and cysteine, 3 mmol/L each) also suppressed the loss of glutathione (82% +/- 13% remained at 5 days). The glutathione precursor, thioproline, a cysteine delivery compound, in combination with glycine and glutamic acid (3 mmol/L each), stimulated the synthesis of glutathione in the kidney during hypothermic perfusion (137% +/- 23% of control values at 5 days). The increase in tissue glutathione stimulated by GSH or other precursors was sensitive to the glutathione synthetase inhibitor, buthionine sulfoximine. This indicated the existence of active glutathione metabolism even at 5 degrees C in perfused kidneys. This study showed that in kidney preservation a loss of glutathione occurred that could be suppressed by the addition of various precursors for glutathione synthesis. The loss of glutathione from preserved kidneys may be one cause of posttransplant renal injury that could be prevented by use of the appropriate glutathione precursors.
Phosphorylation of Nucleosides by the Mutated Acid Phosphatase from <i>Morganella morganii</i> (2000)

A novel nucleoside phosphorylation process using the food additive pyrophosphate as the phosphate source was investigated. The Morganella morganii gene encoding a selective nucleoside pyrophosphate phosphotransferase was cloned. It was identical to the M. morganii PhoC acid phosphatase gene. Sequential in vitro random mutagenesis was performed on the gene by error-prone PCR to construct a mutant library. The mutant library was introduced into Escherichia coli, and the transformants were screened for the production of 5'-IMP. One mutated acid phosphatase with an increased phosphotransferase reaction yield was obtained. With E. coli overproducing the mutated acid phosphatase, 101 g of 5'-IMP per liter (192 mM) was synthesized from inosine in an 88% molar yield. This improvement was achieved with two mutations, Gly to Asp at position 92 and Ile to Thr at position 171. A decreased K(m) value for inosine was responsible for the increased productivity.
Effects of energetic particle precipitation on the SH middle atmosphere in the latest reanalysis data (2016)

第7回極域科学シンポジウム/横断セッション:[IM] 中空大気・熱圏 11月30日（水）統計推理研究所 3階セミナー室D305