gebhart/patrepeval huggingface dataset:
1,25-Dihydroxyvitamin D3 activates secretion of hydrogen peroxide by human monocytes. (1986)

Human blood monocytes cultured in the presence of 1,25(OH)2D3 developed enhanced competence for secretion of H2O2 relative to cells suspended in media. This effect was maximal at a concentration of 10(-8) M 1,25(OH)2D3. After 3 days of incubation, monocyte-derived macrophages (MDM) exposed to 1,25(OH)2D3 demonstrated competence for secretion of H2O2 equivalent to cells exposed to recombinant IFN-gamma. Both IFN-gamma and 1,25(OH)2D3 offset decay of this function among cells in culture after 7 days. Simultaneous exposure of cells to 1,25(OH)2D3 and IFN-gamma did not activate competence for H2O2 secretion more than either agent alone. 24,25(OH)2D3 and 25(OH)2D3 activated MDM but at higher concentration than required for 1,25(OH)2D3. Progesterone did not affect H2O2 production. Incubation of MDM with a monoclonal antibody directed against IFN-gamma inhibited activation induced by lymphokine, and to a lesser extent by cells activated with IFN-gamma; this antibody had an insignificant effect on cells treated with 1,25(OH)2D3. These results suggest that 1,25(OH)2D3 exerts a receptor-mediated effect on monocyte function that results in cellular activation as manifested by enhanced competence for secretion of H2O2. It is possible that smaller concentrations of 1,25(OH)2D3 present in serum are permissive for macrophage activation, or that monocytic phagocytes are exposed to high concentrations of vitamin D metabolites under some clinical circumstances.
Identification and Utility of Markers Linked to the Zucchini Yellow Mosaic Virus Resistance Gene in Watermelon (2009)

Zucchini yellow mosaic virus (ZYMV) is one of the most economically important viruses affecting watermelon [ Citrullus lanatus (Thunb.) Matsun & Nakai var. lanatus ] in the United States. The ZYMV-Florida strain (ZYMV-FL) is considered a major limitation to commercial watermelon production in the United States. Inheritance of resistance to ZYMV-FL is conferred by a recessive gene. This report describes the identification of single-reaction, polymerase chain reaction-based markers linked to the ZYMV-FL resistance gene in watermelon. In this study, we identified a marker ZYMV-resistant polymorphism (ZYRP) linked to the ZYMV-FL resistance gene locus (genetic distance of 8 cM) in an F 2 population, and in a backcross one to the resistant parent population (BC 1 R) (genetic distance of 13 cM). The identification of a single nucleotide polymorphism within the ZYRP marker for the parental genotypes allowed the development of a sequence-characterized amplification region marker linked to the ZYMV-FL resistance gene. Experiments using a BC 2 F 2 population derived from the U.S. Plant Introduction 595203 ( C. lanatus var. lanatus ) and the recurrent parent ‘Charleston Gray’ indicated that the ZYRP marker can be used in marker-assisted selection to identify genotypes containing the gene conferring ZYMV-FL resistance in watermelon.
Cytotoxic T‐lymphocyte interaction with fibronectin and vitronectin: activated adhesion and cosignalling (1997)

Stimulation of cloned cytotoxic T lymphocytes (CTL) with anti-T-cell receptor (TCR) monoclonal antibody (mAb) in solution resulted in rapid and sustained activation of adhesion to immobilized fibronectin (FN) but did not initiate degranulation. Addition of a second antibody (Ab) to further cross-link the TCR substantially increased the level of adhesion and also activated degranulation, as measured by release of serine esterase, in the presence of immobilized FN but not in its absence. Thus, binding to FN can provide a costimulatory signal to activate degranulation. TCR cross-linking also activated CD8-dependent adhesion to class I, and CD8 provided a costimulatory signal upon binding to class I. However, the requirements for activating adhesion and generating the costimulatory signal differed significantly for FN versus class I ligand, suggesting that these two receptor-ligand systems do not share a common mechanism of action. Co-immobilizing FN and alloantigen resulted in increased serine esterase release in comparison with that stimulated by antigen alone, and required the FN and class I be on the same surface. Peptide and antibody blocking demonstrated that CTL binding to FN, and to vitronectin (VN), was mediated by the alpha V beta 3 vitronectin receptor (VNR). Thus, VNR is activated by a signal from the TCR to mediate adhesion to FN or VN, and delivers a costimulatory signal for degranulation via a different mechanism than costimulation by CD8 binding to class I.
Polyaniline: Solutions, Films and Oxidation State (1988)

Abstract The emeraldine oxidation state of polyaniline in its base form, “emeraldine base” can be solution-processed to yield large flexible films which can be doped to the metallic conducting regime (σ ∼ 1-5 S/cm). The approximate solubility of emeraldine base at room temperature in 80% aqueous acetic acid, 60% and 88% aqueous formic acid, dimethyl sulfoxide (DMSO), dimethylformamide (DMF) and N-methylpyrrolidinone (NMP) have been determined. Both emeraldine base and emeraldine hydrochloride can be sublimed onto a variety of substrates to produce high quality, ∼2000 Å thick films which are similar but not identical to emeraldine base. Emeraldine base, which is slowly oxidized by air, can be reconverted to the emeraldine oxidation state by treatment with dilute aqueous acids.
The influence of organizational structure on software quality (2008)

Often software systems are developed by organizations consisting of many teams of individuals working together. Brooks states in the Mythical Man Month book that product quality is strongly affected by organization structure. Unfortunately there has been little empirical evidence to date to substantiate this assertion. In this paper we present a metric scheme to quantify organizational complexity, in relation to the product development process to identify if the metrics impact failure-proneness. In our case study, the organizational metrics when applied to data from Windows Vista were statistically significant predictors of failure-proneness. The precision and recall measures for identifying failure-prone binaries, using the organizational metrics, was significantly higher than using traditional metrics like churn, complexity, coverage, dependencies, and pre-release bug measures that have been used to date to predict failure-proneness. Our results provide empirical evidence that the organizational metrics are related to, and are effective predictors of failure-proneness.
Carbon nanotube film piezoresistors embedded in polymer membranes (2010)

We present carbon nanotube film (CNF) piezoresistors embedded in polymer membranes. CNFs by vacuum filtration are patterned on an Au-deposited Si-wafer and transferred onto the poly-dimethylsiloxane (PDMS) using the weak adhesion property between Au-layer and Si-wafer. Transmittance and I-V characteristic are measured to confirm transferred CNFs as transparent electrodes. The pressure sensor consists of CNF piezoresistors embedded in 130 μm thick circular PDMS membranes. The gauge factor of CNFs at different thickness is obtained around 10–20 when the resistance increases from 2.7 to 5.6 kΩ with applied pressure, which shows that CNFs can be used as transparent piezoresistors in polymer-based microelectromechanical systems.
Adiponectin - Its Role in Metabolism and Beyond (2002)

Adiponectin is a recently identified adipose tissue-derived protein (adipocytokine) with important metabolic effects. It is exclusively expressed in adipose tissue and released into the circulation. Adiponectin expression and/or secretion is increased by insulin like growth factor-1 and ionomycin, and decreased by tumor necrosis factor-alpha, glucocorticoids, beta-adrenergic agonists and cAMP. Data for insulin are somewhat inconclusive. Moreover, adiponectin expression and secretion are increased by activators of peroxisome proliferator-activated receptor (PPAR)-gamma. Besides inhibiting inflammatory pathways, recombinant adiponectin increases insulin sensitivity and improves glucose tolerance in various animal models. This insulin-sensitizing effect appears to be mostly attributable to enhanced suppression of glucose production, but beneficial effects on muscle cannot be excluded. In humans, plasma adiponectin concentrations exceed those of any other hormone by a thousand times; they decrease with obesity and are positively associated with whole-body insulin sensitivity. Therefore, low adiponectin may contribute to the decrease in whole-body insulin sensitivity that accompanies obesity. Furthermore, there is increasing evidence that genetic variants in the adiponectin gene itself and/or in genes encoding adiponectin-regulatory proteins--such as PPAR-gamma--may be associated with hypoadiponectinemia, insulin resistance and type 2 diabetes. This suggests that adiponectin may reflect PPAR-gamma activity in vivo. Finally, reversal or alleviation of hypoadiponectinemia may represent a target for development of drugs improving insulin sensitivity and glucose tolerance.
Image-based environment matting (2002)

Environment matting is a powerful technique for modeling the complex light-transport properties of real-world optically active elements: transparent, refractive and reflective objects. Recent research has shown how environment mattes can be computed for real objects under carefully controlled laboratory conditions. However, many objects for which environment mattes are necessary for accurate rendering cannot be placed into a calibrated lighting environment. We show in this paper that analysis of the way in which optical elements distort the appearance of their backgrounds allows the construction of environment mattes in situ without the need for specialized calibration.Specifically, given multiple images of the same element over the same background, where the element and background have relative motion, it is shown that both the background and the optical element's light-transport path can be computed.We demonstrate the technique on two different examples. In the first case, the optical element's geometry is simple, and evaluation of the realism of the output is easy. In the second, previous techniques would be difficult to apply. We show that image-based environment matting yields a realistic solution. We discuss how the stability of the solution depends on the number of images used, and how to regularize the solution where only a small number of images are available.
Chip design for high-performance DSP (1998)

Advances in silicon technology have been a key development in the realisation of many telecommunication and signal processing systems. In many cases, the development of application-specific digital signal processing (DSP) chips is the most cost-effective solution and provides the highest performance. Advances made in computer-aided design (CAD) tools and design methodologies now allow designers to develop complex chips within months or even weeks. This paper gives an insight into the challenges and design methodologies of implementing advanced high-performance chips for DSP. In particular, the paper reviews some of the techniques used to develop circuit architectures from high-level descriptions and the tools which are then used to realise silicon layout.
UVB radiation-activated genes induced by transcriptional and posttranscriptional mechanisms in rat keratinocytes (1995)

The mechanisms utilized by ultraviolet B (UVB) radiation in the regulation of gene expression, as well as the genetic targets for transmission of the UVB signal, remain incompletely understood. To elucidate the mechanisms and targets for UVB activation in mammalian cells, we screened a keratinocyte cDNA library with differentially subtracted UVB-enriched cDNA probes. Twenty-three UVB-induced cDNA clones were isolated, including cDNAs for keratin, elongation factor-1 alpha, ferritin heavy chain, thioltransferase, cyclin G, cornifin, cellubrevin, poly(A) binding protein, and the surfeit locus. The temporal kinetics of maximal RNA induction following UVB exposure were heterogeneous, varying from 1 to 24 h post-UVB radiation. Analysis of the regulation of gene expression demonstrated that the levels of most UVB-induced mRNAs were also independently induced by serum and cycloheximide, features previously described for genes induced by DNA damage and members of the immediate early gene family. In contrast to results from studies of immediate early genes, treatment of keratinocytes with both serum and cycloheximide resulted in superinduction of only one mRNA transcript. Nuclear run-on assays demonstrated that UVB radiation increased the transcription rate in 8 of 23 genes, suggesting that UVB radiation utilizes both transcriptional and posttranscriptional mechanisms for the modulation of keratinocyte gene expression. The identification of a group of UVB-inducible keratinocyte genes should prove useful for the characterization of the genomic response to UVB radiation and the analysis of the molecular mechanisms underlying the UVB regulation of gene expression.
The Distributional Effects of Carbon Regulation: Why Auctioned Carbon Permits are Attractive and Feasible (1998)

countries agreed to restrict their carbon emissions to, on average, five percent below 1990 levels by 2008 – 2012 (subject to ratification) at the Climate
A Regenerative Chemodosimeter Based on Metal‐Induced Dye Formation for the Highly Selective and Sensitive Optical Determination of Hg<sup>2+</sup> Ions (2005)

Into the blue: Hg2+ -ion-triggered formation of a brightly fluorescent squaraine dye is used as a novel approach for the design of highly selective and sensitive chromofluorogenic probes for the analysis of Hg2+ ions down to concentrations below 2 ppb (see picture). Through the adsorption of the sensor on a solid support a prototype reusable test strip is also generated. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500583_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Characterisation of aperture coupled microstrippatch antennawith thick ground plane (1994)

The feasibility of using a thick ground plane with an aperture coupled microstrip patch antenna while maintaining reasonable antenna performance is demonstrated using moment method and reciprocity analyses in the spectral domain. The thick ground plane, which may serve as a heatsink for active MMIC circuitry, or as a mechanical support for thin substrates, is particularly advantageous in millimetre wave phased array applications. It is found that the effect of ground plane thickness is to reduce the level of coupling from the feed line to the patch.
Analysis of Space Charge Propagation in a Dielectric liquid Employing Field-Thermal Electron Emission Model and Finite Element Method (2009)

In an insulating dielectric liquid such as transformer oil, space charge injection and propagation were analyzed under the Fowler-Nordheim and Richardson-Dushman's thermal emission charge injection conditions for blade-plane electrodes stressed by a step voltage. The governing equations were composed of all five equations such as the Poisson's equation for electric fields, three continuity equations for electrons, negative, and positive ions, and energy balanced equation for temperature distributions. The governing equations for each carrier, the continuity equations, belong to the hyperbolic-type PDE of which the solution has a step change at the space charge front resulting in numerical instabilities. To decrease these instabilities, the governing equations were solved simultaneously by the Finite Element Method (FEM) employing the artificial diffusion scheme as a stabilization technique. Additionally, the terminal current was calculated by using the generalized energy method which is based on the Poynting's theorem, and represents more reliable and stable approach for evaluating discharge current. To verify the proposed method, the discharge phenomena were successfully applied to the blade~plane electrodes, where the radius of blade cap was .
Decreased expression of fibronectin and the <i>α</i>5<i>β</i> <i>1</i> integrin during terminal differentiation of human keratinocytes (1991)

We have examined the expression of fibronectin and the alpha 5 beta 1 fibronectin receptor during terminal differentiation of human epidermal keratinocytes, using involucrin as a terminal differentiation marker. The levels of mRNAs encoding fibronectin and the alpha 5 and beta 1 integrin subunits were measured in keratinocyte populations that had been enriched for involucrin-negative or -positive cells by unit gravity sedimentation or suspension-induced terminal differentiation. All three mRNAs decreased in abundance during terminal differentiation, and the corresponding proteins were localised by immunofluorescence to the basal layer in stratified colonies. We also examined expression in ndk, a strain of epidermal cells with a complete block in terminal differentiation, which, as a result, do not express involucrin. Messenger RNA levels for fibronectin and the alpha 5 and beta 1 subunits were higher in ndk, than in unfractionated keratinocytes and the corresponding proteins were expressed by all ndk, consistent with a basal keratinocyte phenotype. We conclude that expression of fibronectin and the alpha 5 beta 1 fibronectin receptor decreases during terminal differentiation and that such changes are likely to play a role in the selective migration of terminally differentiating cells from the basal epidermal layer.
Suprasupermolecules with Novel Properties:  Metallodendrimers (1999)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSuprasupermolecules with Novel Properties: MetallodendrimersGeorge R. Newkome, Enfei He, and Charles N. MoorefieldView Author Information Center for Molecular Design and Recognition, Department of Chemistry, 4202 East Fowler Avenue, University of South Florida, Tampa, Florida 33620-5250 Cite this: Chem. Rev. 1999, 99, 7, 1689–1746Publication Date (Web):June 12, 1999Publication History Received6 October 1998Revised22 March 1999Published online12 June 1999Published inissue 1 July 1999https://pubs.acs.org/doi/10.1021/cr9800659https://doi.org/10.1021/cr9800659research-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views3398Altmetric-Citations825LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Dendrons,Macromolecules,Metals,Pyrroles,Redox reactions Get e-Alerts
Neuropsychological function in euthymic patients with bipolar disorder (1999)

These findings provide good evidence for the existence of neuropsychological impairment in patients with euthymic bipolar disorder, although the possible effect of medication should not be overlooked. This may be of clinical relevance and raises questions about the course and outcome of the illness.
Control of <i>Candida albicans</i> Murine Vaginitis by Topical Administration of Polycarbophil-Econazole Complex (1998)

The complexation of econazole with the mucoadhesive polycarbophil was found to significantly improve the therapeutic benefit of the drug in the topical treatment of experimental vaginal candidiasis in mice, while no difference in the antimycotic activity exerted by econazole and polycarbophil-econazole could be detected in vitro.
Exercise and Human Circadian Rhythms: What we Know and What we Need to Know (1997)

A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the lack of information on the best times of exercise, the amounts required, and interactions between nonphotic and photic zeitgebers.
Early Index Growth in Germanosilicate Fiber Upon Exposure to Continuous-Wave Ultraviolet Light (2007)

In this paper, high-accuracy measurements of ultraviolet (UV)-induced refractive-index changes (plusmn3times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> ) in germanosilicate optical fiber as a function of intensity and exposure time are presented. To examine the early growth characteristics of the fiber, samples are irradiated with 244-nm light for 100 s at relatively low intensities (0.007-2.7 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). The combined growth data is then interpolated to generate a 3-D "index growth surface" of photo-induced index. An empirically derived mathematical expression relates the index growth to the exposure time and intensity. Evidence is presented that, after exposing the fiber at one intensity, additional growth at a different intensity is dictated by the final index change of the first exposure and the intensity of the second exposure. This "compound growth rule" permits the complete calculation of induced-grating structures produced by such a complex exposure history. Using the index-growth surface and the compound-growth rule, the growth and UV erasure of a fiber Bragg grating is successfully predicted using a modified F-matrix algorithm
Nuclear receptor coactivators and corepressors. (1996)

The nuclear receptors belong to a superfamily of proteins, many of which are ligand-regulated, that bind to specific DNA sequences and control specific gene transcription. Recent data show that, in addition to contacting the basal transcription machinery directly, nuclear receptors inhibit or enhance transcription by recruiting an array of coactivator or corepressor proteins to the transcription complex. In this review we define the properties of these putative coregulatory factors; we describe the basal and coregulatory factors that are currently known to interact with nuclear receptors; we suggest various mechanisms by which coactivators and corepressors act; we discuss issues that are raised by the presence of multiple, perhaps competing, coregulatory factors; and we speculate how these additional regulatory layers may explain the heterogeneity of hormone responses that are observed in normal and malignant tissues.