gebhart/patrepeval huggingface dataset:
Direct Synthesis and Aqueous Solution Properties of Well-Defined Cyclic Sugar Methacrylate Polymers (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTDirect Synthesis and Aqueous Solution Properties of Well-Defined Cyclic Sugar Methacrylate PolymersRavin Narain and Steven P. ArmesView Author Information School of Chemistry, Physics and Environmental Science, Sussex University, Falmer, Brighton, East Sussex, BN1 9QJ, UK Cite this: Macromolecules 2003, 36, 13, 4675–4678Publication Date (Web):May 31, 2003Publication History Received14 March 2003Revised14 May 2003Published online31 May 2003Published inissue 1 July 2003https://pubs.acs.org/doi/10.1021/ma034321hhttps://doi.org/10.1021/ma034321hrapid-communicationACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views2497Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbohydrates,Copolymers,Mixtures,Organic compounds,Radical polymerization Get e-Alerts
A Practical Synthesis of L-FMAU from L-Arabinose (1999)

A practical synthesis of 2'-deoxy-2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil (14, L-FMAU) was developed from L-arabinose. L-Arabinose was converted to L-ribose 5, which was used for the synthesis of bromosugar 12 via 2,3,5-O-tribenzoyl-1-O-acetyl-beta-L-ribofuranose 8, which was subjected to condensation with silylated thymine and the resulting protected L-FMAU 13 was deprotected to afford L-FMAU in 14 steps in 8% overall yield.
Validity of Diagnostic Computer-Based Air and Forehead Bone Conduction Audiometry (2011)

Computer-based audiometry allows for novel applications, including remote testing and automation, that may improve the accessibility and efficiency of hearing assessment in various clinical and occupational health settings. This study describes the validity of computer-based, diagnostic air and forehead bone conduction audiometry when compared wtih conventional industry standard audiometry in a sound booth environment. A sample of 30 subjects (19 to 77 years of age) was assessed with computer-based (KUDUwave 5000) and industry standard conventional audiometers (GSI 61) to compare air and bone conduction thresholds and test-retest reliability. Air conduction thresholds for the two audiometers corresponded within 5 dB or less in more than 90% of instances, with an average absolute difference of 3.5 dB (3.8 SD) and a 95% confidence interval of 2.6 to 4.5 dB. Bone conduction thresholds for the two audiometers corresponded within 10 dB or less in 92% of instances, with an average absolute difference of 4.9 dB (4.9 SD) and a 95% confidence interval of 3.6 to 6.1 dB. The average absolute test-retest threshold difference for bone conduction on the industry standard audiometer was 5.1 dB (5.3 SD) and for the computer-based audiometer 7.1 dB (6.4 SD). Computer-based audiometry provided air and bone conduction thresholds within the test-retest reliability limits of industry standard audiometry.
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC (2018)

Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are required for HCC in obesity. Here, we report that NASH and fibrosis and HCC in obesity can be dissociated. We show that the oxidative hepatic environment in obesity inactivates the STAT-1 and STAT-3 phosphatase T cell protein tyrosine phosphatase (TCPTP) and increases STAT-1 and STAT-3 signaling. TCPTP deletion in hepatocytes promoted T cell recruitment and ensuing NASH and fibrosis as well as HCC in obese C57BL/6 mice that normally do not develop NASH and fibrosis or HCC. Attenuating the enhanced STAT-1 signaling prevented T cell recruitment and NASH and fibrosis but did not prevent HCC. By contrast, correcting STAT-3 signaling prevented HCC without affecting NASH and fibrosis. TCPTP-deletion in hepatocytes also markedly accelerated HCC in mice treated with a chemical carcinogen that promotes HCC without NASH and fibrosis. Our studies reveal how obesity-associated hepatic oxidative stress can independently contribute to the pathogenesis of NASH, fibrosis, and HCC.
Membrane Fusion Mechanisms: The Influenza Hemagglutinin Paradigm and its Implications for Intracellular Fusion (2000)

The mechanism of membrane fusion induced by the influenza virus hemagglutinin (HA) has been extensively characterized. Fusion is triggered by low pH, which induces conformational changes in the protein, leading to insertion of a hydrophobic 'fusion peptide' into the viral membrane and the target membrane for fusion. Insertion perturbs the target membrane, and hour glass-shaped lipidic fusion intermediates, called stalks, fusing the outer monolayers of the two membranes, are formed. Stalk formation is followed by complete fusion of the two membranes. Structures similar to those formed by HA at the pH of fusion are found not only in many other viral fusion proteins, but are also formed by SNAREs, proteins involved in intracellular fusion. Substances that inhibit or promote HA-induced fusion because they affect stalk formation, also inhibit or promote intracellular fusion, cell-cell fusion and even intracellular fission similarly. Therefore, the mechanism of influenza HA-induced fusion may be a paradigm for many intracellular fusion events.
High Active Carbon Supported PdAu Catalyst for Formic Acid Electrooxidation and Study of the Kinetics (2010)

The promotion effect of Au in the catalyst of PdAu/C for formic acid oxidation is confirmed. As the ratio of Pd:Au in the catalyst is 3:1, the PdAu/C-3 catalyst has the largest electrochemical activity compared with that of catalysts with other ratios of Pd:Au. Tafel plots are employed to examine the charge-transfer kinetics of formic acid electrooxidation. The results suggest that the reaction kinetics is faster on PdAu/C than on Pd/C. The kinetic parameters such as the charge transfer parameter and the diffusion coefficient of formic acid electrooxidation on PdAu/C electrocatalysts are obtained under the quasi-steady-state conditions. The temperature dependence of the formic acid oxidation shows that the oxidation reaction is more sensitive to temperature at 0.1 and 0.7 V.
From "Danwei" Society to New Community Building: Opportunities and Challenges for Citizen Participation in Chinese Cities (2006)

Exploring the appropriate role of the public in public administration has been an active and ongoing area of inquiry and experimentation since the birth of the United States (King, Feltey and Susel 1998). Especially in last three decades, public administration has struggled to bring the public into the administrative process in the recognition that many programs cannot be effective without the collaboration between citizens and public administrators.
PA21, a novel phosphate binder, improves renal osteodystrophy in rats with chronic renal failure (2017)

The effects of PA21, a novel iron-based and non-calcium-based phosphate binder, on hyperphosphatemia and its accompanying bone abnormality in chronic kidney disease-mineral and bone disorder (CKD-MBD) were evaluated. Rats with adenine-induced chronic renal failure (CRF) were prepared by feeding them an adenine-containing diet for four weeks. They were also freely fed a diet that contained PA21 (0.5, 1.5, and 5%), sevelamer hydrochloride (0.6 and 2%) or lanthanum carbonate hydrate (0.6 and 2%) for four weeks. Blood biochemical parameters were measured and bone histomorphometry was performed for femurs, which were isolated after drug treatment. Serum phosphorus and parathyroid hormone (PTH) levels were higher in the CRF rats. Administration of phosphate binders for four weeks decreased serum phosphorus and PTH levels in a dose-dependent manner and there were significant decreases in the AUC0-28 day of these parameters in 5% PA21, 2% sevelamer hydrochloride, and 2% lanthanum carbonate hydrate groups compared with that in the CRF control group. Moreover, osteoid volume improved significantly in 5% of the PA21 group, and fibrosis volume and cortical porosity were ameliorated in 5% PA21, 2% sevelamer hydrochloride, and 2% lanthanum carbonate hydrate groups. These results suggest that PA21 is effective against hyperphosphatemia, secondary hyperparathyroidism, and bone abnormalities in CKD-MBD as sevelamer hydrochloride and lanthanum carbonate hydrate are, and that PA21 is a new potential alternative to phosphate binders.
Molecular Cloning and Characterization of Genes for <i>Shigella sonnei</i> Form I O Polysaccharide: Proposed Biosynthetic Pathway and Stable Expression in a Live <i>Salmonella</i> Vaccine Vector (2002)

The gene region for biosynthesis of Shigella sonnei form I O polysaccharide (O-Ps) and flanking sequences, totaling >18 kb, was characterized by deletion analysis to define a minimal construct for development of Salmonella-based live vaccine vector strains. Lipopolysaccharide (LPS) expression and DNA sequence studies of plasmid deletion derivatives indicated form I O-Ps expression from a 12.3-kb region containing a putative promoter and 10 contiguous open reading frames (ORFs), one of which is the transposase of IS630. A detailed biosynthetic pathway, consistent with the predicted functions of eight of the nine essential ORFs and the form I O-Ps structure, is proposed. Further sequencing identified partial IS elements (i.e., IS91 and IS630) and wzz upstream of the form I coding region and a fragment of aqpZ and additional full or partial IS elements (i.e., IS629, IS91, and IS911) downstream of this region. The stability of plasmid-based form I O-Ps expression was greater from low-copy vectors than from high-copy vectors and was enhanced by deletion of the downstream IS91 from plasmid inserts. Both core-linked (i.e., LPS) and non-core-linked (i.e., capsule-like) surface expression of form I O-Ps were detected by Western blotting and silver staining of polyacrylamide gel electrophoresis-separated Shigella and Escherichia coli extracts. However, salmonellae, which have a core that is chemically dissimilar to that of shigellae, expressed only non-core-linked surface-associated form I O-Ps. Finally, attenuated Salmonella enterica serovar Typhi live vaccine vector candidates, containing minimal-sized form I operon constructs, elicited immune protection in mice against virulent S. sonnei challenge, thereby supporting the promise of live, oral vaccines for the prevention of shigellosis.
Evaluation of the Efficacy of Novel Oxazolidinone Analogues against Nontuberculous Mycobacteria In Vitro (2015)

Nontuberculous mycobacteria (NTM) are associated with a number of clinical diseases and only a few antitubercular agents are active against them. Oxazolidinones comprise a novel class of antimicrobials that inhibit bacterial protein synthesis at the ribosome. Linezolid, the first oxazolidinone antibacterial agent approved for clinical use, has excellent activity against some NTM but is ineffective against others. Sy142 and sy144 are novel oxazolidinones with demonstrated activties against Mycobacterium tuberculosis and Staphylococcus aureus. In this work, we compared the susceptibilities of key NTM species to linezolid, sy142, and sy144. The organisms included 21 isolates of Mycobacterium abscessus, 31 of Mycobacterium avium, 11 of Mycobacterium chelonae, 24 of Mycobacterium fortuitum, 26 of Mycobacterium kansasii, and 17 of Mycobacterium intracellulare. For M. kansasii and M. fortuitum, linezolid showed excellent antimicrobial activity, and an equal MIC range was found in sy142 and sy144. For the species that linezolid was less active against, sy142 and sy144 showed greater antimicrobial activities or exhibited equal compared to linezolid. Particularly, for M. avium and M. intracellulare, the in vitro antimicrobial activity of sy142 was 4-fold higher than that of linezolid. These results demonstrate the potential of these compounds to treat NTM infections.
Femtosecond laser fabrication of tubular waveguides in poly(methyl methacrylate) (2004)

Femtosecond laser direct writing is employed for the fabrication of buried tubular waveguides in bulk poly(methyl methacrylate). A novel technique using selective chemical etching is presented to resolve the two-dimensional refractive-index profile of the fabrication structures. End-to-end coupling in the waveguides reveals a near-field intensity distribution that results from the superimposition of several propagating modes with different azimuthal symmetries. Mode analysis of the tubular waveguides is performed using the finite-difference method, and the possible propagating mode profiles are compared with the experimental data.
Interactive important social character identification from large photo collections (2010)

In the paper, we describe a mechanism to identify important social characters by analyzing the social structures embedded in photo collections. We first construct a weighted undirected graph from photo collections by examining the co-appearance of individuals in photos, wherein the weights of edges are measures of the social closeness of the involved individuals (vertices in the graph). Then a graph clustering algorithm that maximizes the modularity of the graph partition is applied to detect the embedded social clusters. Once the social clusters are identified, we measure individual's contribution to the formation of a social cluster to quantify the social importance of each character in the cluster. To compensate the discrepancy between the user-perceived important social characters and the algorithmically computed ones, we propose an interactive browsing scheme to enable viewers quickly identify import social characters that conform to their subjectivity. The effectiveness of the proposed mechanism is demonstrated through experiments on consumer photo collections.
Acoustic inversion of bottom reflectivity and bottom sound-speed profile (1996)

This paper applies a full-field technique to invert bottom sound profile and bottom reflectivity from simulated acoustic data in a shallow water environment. Bottom sound-speed profile and bottom reflectivity have been traditionally estimated using seismic reflection/refraction techniques when acoustic ray paths and travel time can be identified and measured from the data. However, in shallow water, the many multipaths due to bottom reflection/refraction make such identification and measurement rather difficult. A full-field inversion technique is presented here that uses a broad-band source and a vertical array for bottom sound-speed and reflectivity inversion. The technique is a modified matched field inversion technique referred to as matched beam processing. Matched beam processing uses conventional beamforming processing to transform the field data into the beam domain and correlate that with the replica field also in the beam domain. This allows the analysis to track the acoustic field as a function of incident/reflected angle and minimize contamination or mismatch due to sidelobe leakage.
Theoretical Characterization of the Indium Tin Oxide Surface and of Its Binding Sites for Adsorption of Phosphonic Acid Monolayers (2008)

We present a theoretical characterization, based on density functional theory, of the indium tin oxide surface and of the nature of the binding sites that determine the adsorption of phosphonic acid monolayers. The validity of our theoretical description is assessed by comparing our first-principles results to X-ray photoelectron spectroscopy data.
Increasing the Negative Charge of a Macroanion in the Gas Phase via Sequential Charge Inversion Reactions (2004)

Protonated and deprotonated biological molecules in the gas phase play an important role in life sciences research. The structural information accessible from the ions is highly dependent upon their charge states. Therefore, it is desirable to develop means for increasing absolute charge states, particularly for ionization methods, such as MALDI, that yield relatively low charge ions. The work presented here demonstrates the formation of a doubly deprotonated polypeptide or oligonucleotide ion (dianion) from a singly deprotonated analogue via two sequential ion/ion proton-transfer reactions involving charge inversion. The high exoergicity and the large cross section arising from the long-range attractive Coulomb potential of ion/ion reactions make this process plausible. In this example, an overall efficiency of conversion of singly charged ions to doubly charged ions of roughly 8% for polypeptide was noted while lower efficiency (roughly 2%) observed with an oligonucleotide is likely due to a greater degree of neutralization. No other approach to increasing the net negative charge of an anion in the gas phase has as yet been reported.
Evaluation of Nalbuphine Hydrochloride (1980)

The chemical properties, animal and human pharmacology, analgesic efficacy, relative potency, administration, and adverse effects of nalbuphine, a recently marketed, parenteral, strong analgesic with narcotic antagonist properties, are reviewed. Acute, subacute, and chronic toxicity studies in animals revealed no unusual adverse effects. The abuse potential of nalbuphine in man is probably similar to pentazocine. Respiratory depression produced by usual therapeutic doses of nalbuphine is equivalent to that of morphine; at higher than usual doses, nalbuphine produces less respiratory depression. Nalbuphine has few effects on cardiovascular hemodynamics in patients without cardiac disease or with stable ischemic disease. In patients with acute myocardial infarction, nalbuphine has an advantage over morphine, pentazocine, and butorphanol of not producing hypotension. Nalbuphine is as effective and has the same potency as morphine as an analgesic, with about the same onset, peak, and duration of action. Sedation is the most common adverse effect and occurs about as often as with other strong analgesics. Nausea and vomiting occur less often. In contrast to pentazocine, the frequency of psychotomimetic reactions apparently is very low. On the basis of presently available evidence, nalbuphine appears to have fewer disadvantages than any other parenteral strong analgesic.
Identification and Categorization of Liver Toxicity Markers Induced by a Related Pair of Drugs (2011)

Drug-induced liver injury (DILI) is the primary adverse event that results in the withdrawal of drugs from the market and a frequent reason for the failure of drug candidates in the pre-clinical or clinical phases of drug development. This paper presents an approach for identifying potential liver toxicity genomic biomarkers from a liver toxicity biomarker study involving the paired compounds entacapone ("non-liver toxic drug") and tolcapone ("hepatotoxic drug"). Molecular analysis of the rat liver and plasma samples, combined with statistical analysis, revealed many similarities and differences between the in vivo biochemical effects of the two drugs. Six hundred and ninety-five genes and 61 pathways were selected based on the classification scheme. Of the 61 pathways, 5 were specific to treatment with tolcapone. Two of the 12 animals in the tolcapone group were found to have high ALT, AST, or TBIL levels. The gene Vars2 (valyl-tRNA synthetase 2) was identified in both animals and the pathway to which it belongs, the aminoacyl-tRNA biosynthesis pathway, was one of the three most significant tolcapone-specific pathways identified.
Global capitalism and twenty-first century fascism: a US case study (2011)

This seminal article analyses the current structural crisis and instability in an ever more polarised world in relation to earlier systemic crises that were resolved through fascism or through Fordist-Keynesian ‘class compromise’ (the 1930s) and the emergence of capitalist globalisation (the 1970s). The authors identify three basic responses to the crisis: popular insurgency from below; reformist stabilisation from above; and, a twenty-first century neo-fascism. Looking specifically at the US, they analyse political and economic developments that demonstrate fascistic characteristics. While no simple replication of the past, the emergence of a Christian Right since the mid-1980s, the growth of certain currents within the Tea Party movement, the sharp increase in violent hate groups, the spread of a vicious anti-immigrant movement, the psychopathology of white decline, sharp militarisation and pervasive policing give some indications of the rise of fascist tendencies. But what is crucial today is the sophistication of such a project, made possible by the ideological domination of media together with new surveillance and social control technologies that allow it to rely more on selective than generalised repression. In calling for a co-ordinated fightback, both in the US and beyond, the authors see the only viable solution to the crisis of global capitalism as a massive redistribution of wealth and power downward towards the poor majority of humanity, along the lines of a twenty-first century democratic socialism.
A distributed crossbar switch scheduler for on-chip networks (2004)

A scheduling algorithm is proposed for a lightweight on-chip crossbar switch in on-chip networks. The proposed NA-MOO algorithm distributes the arbitration computing over all of the crossbar fabric nodes. Its implementation shows that it can reduce >60% area and >20% computation delay compared to the conventional round robin based SLIP algorithm. Its feasibility is analyzed by using an SoC for HDTV as an example. The proposed techniques are area-efficient and show higher performance for the on-chip interconnection networks.