gebhart/patrepeval huggingface dataset:
Preparation and characterization of thionyl chloride-activated succinamidopropyl-glass as a covalent immobilization matrix. (1984)

The reaction of succinamidopropyl-glass with nonaqueous thionyl chloride followed by washing with water produces an activated surface which reacts with amino and thiol groups under nondenaturing conditions. Subsequent treatment of the covalently immobilized species with dilute hydroxylamine at pH 7 and room temperature releases about 80% of those molecules attached through amino groups and about 50% of those attached through thiol groups. The succinamidopropyl group appears to be a minimum requirement for such surface reactivity. The derivatized glass beads are stable during storage, and immobilization is achieved by simply contacting the surface with a solution of the protein or biochemical species to be attached. Moreover, the activated succinamidopropyl sites can be dispersed within an inert surface of glycerolpropyl sites. Such dispersion improves the subsequent release of immobilized protein and should provide a useful technique for preparation of a wide variety of specific matrices for affinity chromatography. It was possible to obtain, in solution, molecules which had been refolded from a completely denatured state in an immobilized form; however, extensive unfolding of proteins in strong denaturants reduced by roughly 50% the amount of protein which could be subsequently released.
Cross Metathesis Route in Sphingomyelin Synthesis (2004)

Abstract Cross metathesis reaction of short chain Boc sphingosine using Grubbs’ 2nd generation catalyst proceeded in stereoselective manner to afford Boc sphingosine in good yield. An efficient synthesis of sphingomyelin was achieved from the obtained Boc sphingosine using our own phosphorylation reagent.
<i>Quantum Theory and Measurement</i> (1984)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. A. Wheeler, W. H. Zurek, Leslie E. Ballentine; Quantum Theory and Measurement. Am. J. Phys. 1 October 1984; 52 (10): 955. https://doi.org/10.1119/1.13804 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAmerican Association of Physics TeachersAmerican Journal of Physics Search Advanced Search |Citation Search
<i>Swertia</i> (Gentianaceae): Chemical and Pharmacological Aspects (2004)

A compilation of the constituents isolated from Swertia species covering the literature up to December 2003 is presented. The botanical classification and ethno-pharmacology of Swertia plants, as well as the biological activities and pharmacological applications of both distinct phytochemicals and medicinally active plant materials (formulations, extracts, etc.) are discussed in detail.
Clean STD‐NMR spectrum for improved detection of ligand‐protein interactions at low concentration of protein (2010)

Saturation transfer difference (STD)-NMR has been widely used to screen ligand compound libraries for their binding activities to proteins and to determine the binding epitopes of the ligands. We report herein, a Clean STD-NMR method developed to overcome false positives (artifacts) observed in the STD-NMR spectrum due to the power spillover of RF irradiation. The method achieved higher degree of resonance saturation through digital editing of two STD-NMR spectra to generate a concatenated difference spectrum and three times of sensitivity enhancement for a loose binding complex involving DNA oligonucleotide and an RNA-binding protein, CUGBP-1ab (25.2 kDa). The interesting binding characteristics of the complex dCTGTCT-CUGBP1ab were obtained. The method was applied to a mixture of small ligand and bovine serum albumin protein (BSA, 66.3 kDa), and detected the intermolecular contacts at a BSA concentration as low as 0.1 µM, a working concentration useful for the detection of proteins of low solubility at biologically relevant conditions.
A new polar Fourier transform for computer-aided tomography and spotlight synthetic aperture radar (1988)

An algorithm for calculating the Fourier transform of certain discrete measures supported on a two-dimensional polar grid is described. The algorithm utilizes a modified Bluestein chirp algorithm to directly calculate the Fourier transform values over a rectangular grid. Applications to computer-aided tomography and spotlight synthetic aperture radar are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Clinical Trials in Oncology (2010)

Studies that are unimpeachably thorough, non-political, unbiased, and properly designed These are the standards to which everyone in clinical research aspires. Yet, the difficulties in designing trials and interpreting data are subtle and ever present. The new edition of Clinical Trials in Oncology provides a concise, nontechnical, and now
AAPE proliposomes for topical atopic dermatitis treatment (2014)

AAPE proliposomes maintained protein stability and showed promising results for atopic dermatitis treatment.
Design with architectural objects in industrialised house-building (2008)

Architectural design has different conditions in different building processes. Traditionally, the building process is project oriented with a unique composition of participants in each project. The architect often has an initial role of defining the physical framework regarding function, materials and aesthetics, also affecting later decisions concerning technical solutions, production and economy. The work is governed by established routines and a clear division of responsibilities. It is characterized by strong time pressure and cost awareness in combination with limited possibilities of cooperation in early stages between design and production (Borgbrant 2003, Winch 2002).
A Survey on TCP-Friendly Congestion Control (extended version) (2001)

New trends in communication, in particular the deployment of multicast and real-time audio/video streaming applications, are likely to increase the percentage of non-TCP traffic in the Internet. These applications rarely perform congestion control in a TCP-friendly manner, i.e., they do not share the available bandwidth fairly with applications built on TCP, such as web browsers, FTP- or email-clients. The Internet community strongly fears that the current evolution could lead to a congestion collapse and starvation of TCP traffic. For this reason, TCP-friendly protocols are being developed that behave fairly with respect to co-existent TCP flows. In this article, we present a survey of current approaches to TCP-friendliness and discuss their characteristics. Both unicast and multicast congestion control protocols are examined, and an evaluation of the different approaches is presented.
Activation of Bladder Mast Cells in Interstitial Cystitis (1995)

Interstitial cystitis (IC) is a sterile, inflammatory bladder condition characterized by urinary frequency and urgency, as well as burning and suprapubic pain, which occurs more frequently in women who may suffer for years before diagnosis. An increased number of mast cells have been associated with IC, but the published reports are inconclusive and often conflicting. Human bladder biopsies were analysed blindly for the degree of activation of mast cells in control and IC patients. It was found that mast cells from IC patients averaged as high as 34 cells/mm2 as compared to less than 16/mm2 in controls. Electron microscopy revealed that over 90% of mast cells from IC patients were activated to various degrees. It is concluded that mast cell activation is a pathologic characteristic for IC.
Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. (1996)

Recent evidence indicates that long-chain polyunsaturated fatty acids (PUFAs) can prevent cardiac arrhythmias by a reduction of cardiomyocyte excitability. This was shown to be due to a modulation of the voltage-dependent inactivation of both sodium (INa) and calcium (ICa) currents. To establish whether PUFAs also regulate neuronal excitability, the effects of PUFAs on INa and ICa were assessed in CA1 neurons freshly isolated from the rat hippocampus. Extracellular application of PUFAs produced a concentration-dependent shift of the voltage dependence of inactivation of both INa and ICa to more hyperpolarized potentials. Consequently, they accelerated the inactivation and retarded the recovery from inactivation. The EC50 for the shift of the INa steady-state inactivation curve was 2.1 +/- 0.4 microM for docosahexaenoic acid (DHA) and 4 +/- 0.4 microM for eicosapentaenoic acid (EPA). The EC50 for the shift on the ICa inactivation curve was 2.1 +/- 0.4 for DHA and > 15 microM for EPA. Additionally, DHA and EPA suppressed both INa and ICa amplitude at concentrations > 10 microM. PUFAs did not affect the voltage dependence of activation. The monounsaturated oleic acid and the saturated palmitic acid were virtually ineffective. The combined effects of the PUFAs on INa and ICa may reduce neuronal excitability and may exert anticonvulsive effects in vivo.
Chirp control of a single-mode, good beam quality, zigzag dye laser (1997)

We report a substantial reduction of frequency chirp of a single-mode laser-pumped zigzag dye laser. A linear optical cavity using counterpropagating orthogonally polarized waves was injection-seeded at 568 mn and operated with a laser output of about 1 J. The chirp was controlled by an intracavity Pockels cell that was configured to add optical density at a rate which counterbalanced the decrease in optical density due to dye-solvent heating during the /spl sim/1-/spl mu/s laser pulse. Heterodyne measurements were used to determine that the bandwidth was near the transform limit and chirp rate of /spl sim/1 MHz//spl mu/s. The beam quality of the laser was measured at 10 Hz as 1.7 XDL.
Recent developments in fiber optic ring laser gyros (1991)

It was previosly observed (Aronowitz, 1971; Zarinetchi et al., 1989) that, in a Brillouin fiber-optic laser gyro with identical laser frequencies along the counterpropagating directions, there occur, at low rotation rates, the lock-in phenomena normally encountered in bulk-optic ring laser gyros due to backscattering. This paper presents rotation data that are free from lock-in phenomena, from a laser gyro in which the two Brillouin lasers are separated by a fixed offset at zero rotation rate. Also presented is a measurement of the beat between the two counterpropagating Brillouin lasers, which determines the ultimate performance of this gyro.
Non-lithium treatment for bipolar disorder. (1990)

Lithium carbonate is the drug of choice for the management of bipolar disorder, but 20% to 40% of patients do not exhibit adequate response to this agent. Moreover, adjunctive therapy with tricyclic antidepressants and monoamine oxidase inhibitors (for depression) and neuroleptics (for mania) is widely prescribed in most lithium clinics. These agents, however, may precipitate or exacerbate the subsequent phase of the illness. More recently, carbamazepine, an anticonvulsant drug, has shown promise in the management of bipolar illness. Used either alone or in combination with lithium, carbamazepine has been associated with a response rate of approximately 65% in more than 500 patients enrolled in controlled and uncontrolled studies. The drug's antimanic effects have been clearly demonstrated, but its antidepressant effects must undergo further examination. Other anticonvulsants (such as valproate) appear highly effective. The high-potency benzodiazepines (such as clonazepam) and calcium channel blockers (such as verapamil) are also being evaluated in this patient population.
MCYT baseline corpus: a bimodal biometric database (2003)

The current need for large multimodal databases to evaluate automatic biometric recognition systems has motivated the development of the MCYT bimodal database. The main purpose has been to consider a large scale population, with statistical significance, in a real multimodal procedure, and including several sources of variability that can be found in real environments. The acquisition process, contents and availability of the single-session baseline corpus are fully described. Some experiments showing consistency of data through the different acquisition sites and assessing data quality are also presented.
CCL18 in a Multiplex Urine-Based Assay for the Detection of Bladder Cancer (2012)

The early detection of bladder cancer (BCa) is pivotal for successful patient treatment and management. Through genomic and proteomic studies, we have identified a number of bladder cancer-associated biomarkers that have potential clinical utility. In a case-control study, we examined voided urines from 127 subjects: 64 tumor-bearing subjects and 63 controls. The urine concentrations of the following proteins were assessed by enzyme-linked immunosorbent assay (ELISA); C-C motif chemokine 18 (CCL18), Plasminogen Activator Inhibitor 1 (PAI-1) and CD44. Data were compared to a commercial ELISA-based BCa detection assay (BTA-Trak©) and voided urinary cytology. We used analysis of the area under the curve of receiver operating characteristic curves to compare the ability of CCL18, PAI-1, CD44, and BTA to detect BCa in voided urine samples. Urinary concentrations of CCL18, PAI-1, and BTA were significantly elevated in subjects with BCa. CCL18 was the most accurate biomarker (AUC; 0.919; 95% confidence interval [CI], 0.8704-0.9674). Multivariate regression analysis highlighted CCL18 (OR; 18.31; 95% CI, 4.95-67.70, p<0.0001) and BTA (OR; 6.43; 95% CI, 1.86-22.21, p = 0.0033) as independent predictors of BCa in voided urine samples. The combination of CCL18, PAI-1 and CD44 improved the area under the curve to 0.938. Preliminary results indicate that CCL18 was a highly accurate biomarker for BCa detection in this cohort. Monitoring CCL18 in voided urine samples has the potential to improve non-invasive tests for BCa diagnosis. Furthermore using the combination of CCL18, PAI-1 and CD44 may make the model more robust to errors to detect BCa over the individual biomarkers or BTA.
SALELE process from theory to fabrication (2019)

In this work we are introducing a manufacturing flow for the SALELE Process in details. Starting with layout decomposition, where the drawn layer is decomposed into 4 Masks: 2 Metal-like Masks, and 2 Block-like Masks. Then each of these masks is subjected to Optical Proximity Correction (OPC) process, and here we explain more about the OPC recipe development for each mask. Then we introduce a verification flow that performs two levels of verifications: (a) Litho verification, where the litho fidelity of each mask is quantified based on image quality measurements. (b) Final Manufactured shapes verification vs. expected output. This work has been carried out on an N3 candidate layout designed by IMEC.
[Quality criteria for intra-oral roentgen images]. (1990)

The apical and marginal parodontium are the main targets in dental roentgenology. The most important structural details are of 0.1 to 1.0 mm size. Their imaging is determined by - among other parameters - The X-ray film technique. This article presents quality criteria for a number of standard projections, that appear suitable for assessing the image quality. Other factors determining the characteristics of an x-ray film have been neglected, the only exception being a short treatise on the importance of contrast.
Facile Synthesis of Branched Poly(vinyl alcohol)s (2006)

Poly(vinyl alcohol) (PVOH) is a ubiquitous synthetic polymer that finds widespread application in biological and medical products through to personal, domestic, and industrial products. The currently available range of materials all have linear backbone architectures with interesting solubility, rheological, and interfacial properties. The latter might be significantly broadened if complementary polymers with branched backbone architectures could be synthesized, especially if the methodology involved only minor changes from that currently practiced. We have now synthesized branched PVOHs via conventional free radical copolymerization of vinyl acetate (VAc) and triallyl-triazine-trione (TTT), in 2-isopropoxy ethanol (IPE) solvent in the presence of appropriate thiol free radical chain transfer agents, followed by alcoholysis of the so-formed branched poly(vinyl acetates)s (PVAc)s with methanol. Balancing the mole ratio of TTT to thiol allows high conversion to branched materials to be achieved while inhibiting cross-linking and gelation of the products. The branch points derived from the TTT comonomer have been shown to be conserved during the alcoholysis step, and extensive characterization of the PVAc precursors and the derived PVOHs using multiple detector size exclusion chromatographic (SEC) instrumentation has confirmed the highly branched nature of both groups of polymers. Final confirmation of the branched architecture of the PVOH samples has been made by reacetylation of some samples, in effect to regenerate their PVAc precursors. SEC analysis of the latter has indeed shown these to be architecturally very similar to the original precursor PVAcs. This novel methodology for synthesizing branched PVOHs involves relatively minor adjustments to the currently used industrial process for linear PVOHs and so offers good prospects for scale-up and exploitation.
Synthesis of Porous Palladium Superlattice Nanoballs and Nanowires (2000)

Ordered arrays of palladium nanostructures have been obtained inside MCM-48 and SBA-15, using chemical vapor infiltration. Removal of the silica matrix affords porous three-dimensional Pd nanoballs and one-dimensional Pd nanowires, depending on the architecture of the silicate host.
Single Cone Mirror Omni-Directional Stereo (2001)

Omni-directional view and stereo information for scene points are both crucial in many computer vision applications. In some demanding applications like autonomous robots, we need to acquire both in real-time without sacrificing too much image resolution. This work describes a novel method to meet all the stringent demands with relatively simple setup and off-the-shelf equipments. Only one simple reflective surface and two regular (perspective) camera views are needed. First we describe the novel stereo method. Then we discuss some variations in practical implementation and their respective tradeoffs. 1.
Identification and Molecular Characterization of the Switchgrass AP2/ERF Transcription Factor Superfamily, and Overexpression of PvERF001 for Improvement of Biomass Characteristics for Biofuel (2015)

The APETALA2/ethylene response factor (AP2/ERF) superfamily of transcription factors (TFs) plays essential roles in the regulation of various growth and developmental programs including stress responses. Members of these TFs in other plant species have been implicated to play a role in the regulation of cell wall biosynthesis. Here, we identified a total of 207 AP2/ERF TF genes in the switchgrass genome and grouped into four gene families comprised of 25 AP2-, 121 ERF-, 55 DREB (dehydration responsive element binding)-, and 5 RAV (related to API3/VP) genes, as well as a singleton gene not fitting any of the above families. The ERF and DREB subfamilies comprised seven and four distinct groups, respectively. Analysis of exon/intron structures of switchgrass AP2/ERF genes showed high diversity in the distribution of introns in AP2 genes versus a single or no intron in most genes in the ERF and RAV families. The majority of the subfamilies or groups within it were characterized by the presence of one or more specific conserved protein motifs. In silico functional analysis revealed that many genes in these families might be associated with the regulation of responses to environmental stimuli via transcriptional regulation of the response genes. Moreover, these genes had diverse endogenous expression patterns in switchgrass during seed germination, vegetative growth, flower development, and seed formation. Interestingly, several members of the ERF and DREB families were found to be highly expressed in plant tissues where active lignification occurs. These results provide vital resources to select candidate genes to potentially impart tolerance to environmental stress as well as reduced recalcitrance. Overexpression of one of the ERF genes (PvERF001) in switchgrass was associated with increased biomass yield and sugar release efficiency in transgenic lines, exemplifying the potential of these TFs in the development of lignocellulosic feedstocks with improved biomass characteristics for biofuels.
Synthetic of α-Methylhistidine by Catalytic Phase-Transfer Alkylations (1989)

Abstract α-Methylhistidine was prepared by two complementary routes using a catalytic phase-transfer alkylation procedure. Construction of the product was achieved either by alkylation of an alanine Schiff base ester with an imidazole-containing electrophile or by methylation of a protected histidine derivative. Hydrolysis of the protecting groups afforded α-MeHis·2HCl in 27–41% overall yield.
ZigBee/ZigBee PRO Security Assessment Based on Compromised Cryptographic Keys (2010)

Sensor networks have many applications in monitoring and controlling of environmental properties such as sound, acceleration, vibration and temperature. Due to limited resources in computation capability, memory and energy, they are vulnerable to many kinds of attacks. The ZigBee specification, based on the 802.15.4 standard, defines a set of layers specifically suited to sensor networks. These layers support secure messaging using symmetric cryptographic. This paper presents two different ways for grabbing the cryptographic key in ZigBee: remote attack and physical attack. It also surveys and categorizes some additional attacks which can be performed on ZigBee networks: eavesdropping, spoofing, replay and DoS attacks at different layers. From this analysis, it is shown that some vulnerabilities still in the existing security schema in ZigBee technology.
Development and stability evaluation of enteric coated Diclofenac sodium tablets using Sureteric. (2012)

This study was aimed to develop a stable enteric coated diclofenac sodium tablets using Sureteic without a subcoating layer. Diclofenac uncoated tablets were developed and manufactured through the non direct compression process. Sureteric white aqueous coating dispersion was used as enteric coating material. Sureteric is a special mixture of Polyvinyl Acetate Phthalate (Phthalavin (R), PVAP), plasticizers and other ingredients in a suitable optimized dry powder formulation. The obtained enteric coated tablets were subjected to disintegration and no sign of cracking was observed when they placed in a hydrochloric solution at pH 1.2, but they were completely disintegrated within 10 minutes when they putted in buffered solution at pH6.8. Dissolution test was also conducted by placing tablets in 0.1 M HCl for 2 hours and then 1 hour in phosphate buffer at pH 6.8. Less than 0.9% of drug was released in the acidic phase and up to 97% in the basic medium. These results show that Sureteric can be successfully used to produce diclofenac sodium enteric coated tablets in order to prevent its release in the stomach and facilitate immediate release of the drug in the duodenum. These findings suggest that aqueous enteric coating with Sureteric system is an easy and economical approach for preparing stable diclofenac sodium enteric coat without the use of a subcoating layer.