gebhart/patrepeval huggingface dataset:
Super-Interpolation With Edge-Orientation-Based Mapping Kernels for Low Complex Upscaling (2015)

With the advent of ultrahigh-definition (UHD) video services, super-resolution (SR) techniques are often required to generate high-resolution (HR) images from low-resolution (LR) images, such as HD images. To generate such HR images and a video of UHD resolutions in limited computing devices with hardware and software, low complex but excellent SR methods are particularly required. In this paper, we present a novel and fast SR method, called super-interpolation (SI), by unifying an interpolation step and a quality-enhancement step. The proposed SI method utilizes edge-orientation (EO)-based pre-learned kernels, which inherits the simplicity of interpolation and the quality enhancement of SR. It performs SR directly from the initial resolution of an input image to the target resolution of an up-scaled output image without requiring any intermediate interpolated image. The proposed SI method involves offline training and online up-scaling phases. In the offline training phase, training LR image patches are clustered based on their edge orientations into different EO classes for which class-dependent linear mapping functions are learned between training LR and HR image patches. In up-scaling phase, an HR output image patch for each LR input image patch is generated by applying an appropriate linear mapping function selected based on the EO of LR input image patch. Our proposed SI method is intensively compared with the ten state-of-the-art SR methods for common image sets and many HD/UHD images. The experimental results show that the SI method yields the smallest running time and requires relatively small hardware resources. It outperforms the six state-of-the-art methods in average (peak signal-to-noise ratio) PSNR/(structural similarity) SSIM, and exhibits competitive or somewhat lower PSNR/SSIM performance compared with the others.
The “Slab” laser: Productivity and processing advantages in industrial applications (1990)

Now that a “Slab” YAG laser is available as a choice for a laser source in the industrial laser market place, an understanding of this new generation of solid state laser is appropriate if its full potential in materials processing is to be realized. In this presentation, basic “Slab” laser design will be discussed along with the intrinsic advantages of “Slab” over “Rod” crystal geometry. It will be shown how these advantages result in high power/high brightness beams, consistent in quality over the laser’s entire power range, and how lower operation and maintenance costs qualify the “Slab” laser as a true industrial tool. The simplicity and flexibility of the resonator will be discussed and material processing data will be presented. Information on some possibilities for future developments with “Slab” lasers will conclude the presentation.
Glutathione Peroxidase-like Antioxidant Activity of Diaryl Diselenides:  A Mechanistic Study (2001)

The synthesis, structure, and thiol peroxidase-like antioxidant activities of several diaryl diselenides having intramolecularly coordinating amino groups are described. The diselenides derived from enantiomerically pure R-(+)- and S-(-)-N,N-dimethyl(1-ferrocenylethyl)amine show excellent peroxidase activity. To investigate the mechanistic role of various organoselenium intermediates, a detailed in situ characterization of the intermediates has been carried out by (77)Se NMR spectroscopy. While most of the diselenides exert their peroxidase activity via selenol, selenenic acid, and selenenyl sulfide intermediates, the differences in the relative activities of the diselenides are due to the varying degree of intramolecular Se.N interaction. The diselenides having strong Se.N interactions are found to be inactive due to the ability of their selenenyl sulfide derivatives to enhance the reverse GPx cycle (RSeSR + H(2)O(2) = RSeOH). In these cases, the nucleophilic attack of thiol takes place preferentially at selenium rather than sulfur and this reduces the formation of selenol by terminating the forward reaction. On the other hand, the diselenides having weak Se.N interactions are found to be more active due to the fast reaction of the selenenyl sulfide derivatives with thiol to produce diphenyl disulfide and the expected selenol (RSeSR + PhSH = PhSSPh + RSeH). The unsubstituted diaryl diselenides are found to be less active due to the slow reactions of these diselenides with thiol and hydrogen peroxide and also due to the instability of the intermediates. The catalytic cycles of 18 and 19 strongly resemble the mechanism by which the natural enzyme, glutathione peroxidase, catalyzes the reduction of hydroperoxides.
Enhancement of solar cell efficiency using two-dimensional photonic crystals (2010)

During the last years, much attention has been paid to photonic crystals (PC) for different applications, but only recently they have been proposed and showed useful for applications in solar cells. Little work has been done in the actual manufacture and characterization of a complete solar cell with a two-dimensional photonic crystal (2D-PC) on its front surface, conceived as a periodic distribution of the dielectric constant in the plane (the surface of the solar cell) and involving sub-wavelength motifs. In this case, the photonic crystal effect is different from the one happening in slabs or suspended membranes. Despite the partial vertical confinement, there may be some reasons that can justify the use of photonic crystal front surface with sub-wavelength motifs. Experimental results on actual devices with a photonic crystal nanopatterned layer will be shown, along with reflectivity studies on PC lattices with different symmetries and shapes.
Ionic liquid processing of cellulose (2012)

Utilization of natural polymers has attracted increasing attention because of the consumption and over-exploitation of non-renewable resources, such as coal and oil. The development of green processing of cellulose, the most abundant biorenewable material on Earth, is urgent from the viewpoints of both sustainability and environmental protection. The discovery of the dissolution of cellulose in ionic liquids (ILs, salts which melt below 100 °C) provides new opportunities for the processing of this biopolymer, however, many fundamental and practical questions need to be answered in order to determine if this will ultimately be a green or sustainable strategy. In this critical review, the open fundamental questions regarding the interactions of cellulose with both the IL cations and anions in the dissolution process are discussed. Investigations have shown that the interactions between the anion and cellulose play an important role in the solvation of cellulose, however, opinions on the role of the cation are conflicting. Some researchers have concluded that the cations are hydrogen bonding to this biopolymer, while others suggest they are not. Our review of the available data has led us to urge the use of more chemical units of solubility, such as 'g cellulose per mole of IL' or 'mol IL per mol hydroxyl in cellulose' to provide more consistency in data reporting and more insight into the dissolution mechanism. This review will also assess the greenness and sustainability of IL processing of biomass, where it would seem that the choices of cation and anion are critical not only to the science of the dissolution, but to the ultimate 'greenness' of any process (142 references).
Evidence for Transfer of CMY-2 AmpC β-Lactamase Plasmids between <i>Escherichia coli</i> and <i>Salmonella</i> Isolates from Food Animals and Humans (2001)

Escherichia coli is an important pathogen that shows increasing antimicrobial resistance in isolates from both animals and humans. Our laboratory recently described Salmonella isolates from food animals and humans that expressed an identical plasmid-mediated, AmpC-like beta-lactamase, CMY-2. In the present study, 59 of 377 E. coli isolates from cattle and swine (15.6%) and 6 of 1,017 (0.6%) isolates of human E. coli from the same geographic region were resistant to both cephamycins and extended-spectrum cephalosporins. An ampC gene could be amplified with CMY-2 primers in 94.8% of animal and 33% of human isolates. Molecular epidemiological studies of chromosomal DNA revealed little clonal relatedness among the animal and human E. coli isolates harboring the CMY-2 gene. The ampC genes from 10 animal and human E. coli isolates were sequenced, and all carried an identical CMY-2 gene. Additionally, all were able to transfer a plasmid containing the CMY-2 gene to a laboratory strain of E. coli. CMY-2 plasmids demonstrated two different plasmid patterns that each showed strong similarities to previously described Salmonella CMY-2 plasmids. Additionally, Southern blot analyses using a CMY-2 probe demonstrated conserved fragments among many of the CMY-2 plasmids identified in Salmonella and E. coli isolates from food animals and humans. These data demonstrate that common plasmids have been transferred between animal-associated Salmonella and E. coli, and identical CMY-2 genes carried by similar plasmids have been identified in humans, suggesting that the CMY-2 plasmid has undergone transfer between different bacterial species and may have been transmitted between food animals and humans.
miRNA-27b Targets Vascular Endothelial Growth Factor C to Inhibit Tumor Progression and Angiogenesis in Colorectal Cancer (2013)

Colorectal cancer (CRC) is one of the most prevalent cancers globally and is one of the leading causes of cancer-related deaths due to therapy resistance and metastasis. Understanding the mechanism underlying colorectal carcinogenesis is essential for the diagnosis and treatment of CRC. microRNAs (miRNAs) can act as either oncogenes or tumor suppressors in many cancers. A tumor suppressor role for miR-27b has recently been reported in neuroblastoma, while no information about miR-27b in CRC is available. In this study, we demonstrated that miR-27b expression is decreased in most CRC tissues and determined that overexpression of miR-27b represses CRC cell proliferation, colony formation and tumor growth in vitro and in vivo. We identified vascular endothelial growth factor C (VEGFC) as a novel target gene of miR-27b and determined that miR-27b functioned as an inhibitor of tumor progression and angiogenesis through targeting VEGFC in CRC. We further determined that DNA hypermethylation of miR-27b CpG islands decreases miR-27b expression. In summary, an anti-tumor role for miR-27b and its novel target VEGFC in vivo could lead to tumor necrosis and provide a rationale for developing miR-27b as a therapeutic agent.
Quantitative risk assessment for lung cancer from exposure to metal ore dust. (1992)

To quantitatively assess risk for lung cancer of metal miners, a historical cohort study was conducted. The cohort consisted of 1113 miners who were employed to underground work for at least 12 months between January 1, 1960 and December 12, 1974. According to the records of dust concentration, a cumulative dust dose of each miner in the cohort was estimated. There were 162 deaths in total and 45 deaths from lung cancer with a SMR of 2184. The SMR for lung cancer increased from 1019 for those with cumulative dust dose of less than 500 mg-year to 2469 for those with the dose of greater than 4500 mg-year. Furthermore, the risk in the highest category of combined cumulative dust dose and cigarette smoking was 46-fold greater than the lowest category of dust dose and smoking. This study showed that there was an exposure-response relationship between metal ore dust and lung cancer, and an interaction of lung cancer between smoking and metal ore dust exposure.
Patterning of spinal cord oligodendrocyte development by dorsally derived BMP4 (2004)

Oligodendrocyte precursors (OPCs) initially arise in the motor neuron domain of the ventral ventricular zone of the developing spinal cord. After dispersal throughout gray and white matter, OPCs differentiate in a characteristic ventral to dorsal sequence. The spatial localization of OPC induction is in part a result of both positive local sonic hedgehog signaling and dorsally derived inhibitory cues. One component of dorsal inhibitory signals seems to be members of the transforming growth factor beta (TGFbeta) superfamily such as the bone morphogenetic proteins (BMPs). We show that during the initial appearance and subsequent maturation of OPCs, BMP4 was expressed specifically in the dorsal midline and its expression was correlated spatially and temporally with phospho-Smad 1+, BMP4-responsive cells. Implantation of sonic hedgehog (Shh)-coated beads adjacent to dorsal spinal cord in Xenopus embryos induced ectopic dorsal OPCs whereas BMP4-coated beads inhibited OPC appearance. More importantly, blocking endogenous dorsal BMP4 with anti-BMP4-coated beads locally induced ectopic OPCs. Similar results were obtained using soluble ligands on slice preparations of rodent spinal cord in vitro. In dissociated cell cultures of embryonic rat spinal cord, Shh and BMP4 had antagonistic effects on OPC development and the sensitivity of oligodendrocyte lineage cells to BMP4 increased with maturation. These data suggest that BMP4 contributes to the pattern of spinal cord oligodendrogenesis by regulating both induction and maturation of spinal cord OPCs.
A user interface toolkit based on graphical objects and constraints (1988)

One of the most difficult aspects of creating graphical, direct manipulation user interfaces is managing the relationships between the graphical objects on the screen and the application data structures that they represent. Coral (Constraint-based Object-oriented Relations And Language) is a new user interface toolkit under development that uses efficiently-implemented constraints to support these relationships. Using Coral, user interface designers can construct interaction techniques such as menus and scroll bars. More importantly, Coral makes it easy to construct direct-manipulation user interfaces specialized to particular applications. Unlike previous constraint-based toolkits, Coral supports defining constraints in the abstract, and then applying them to different object instances. In addition, it provides iteration constructs where lists of items (such as those used in menus) can be constrained as a group. Coral has two interfaces: a declarative interface that provides a convenient way to specify the desired constraints, and a procedural interface that will allow a graphical user interface management system (UIMS) to automatically create Coral calls.
Drug interactions of the statins and consequences for drug selection (2001)

Cholesterol-lowering drugs such as HMG-CoA reductase inhibitors ("statins") are increasingly used in hypercholesterolemic patients who suffer from multiple concomitant diseases, and are therefore taking multiple drugs. The statins do not differ in their mechanism of action (pharmacodynamics), but there are differences in the affinity to the target enzyme as well as differences in pharmacokinetic properties, which need to be considered when choosing a statin for a specific patient. The most critical side effect of statins is development of myopathy, which becomes evident as muscle pain, weakness, and elevation of serum creatine kinase activity. The incidence of myopathy is usually low. However, myopathy and rhabdomyolysis are more frequent when statins are combined with other drugs that inhibit cytochrome P450-dependent metabolism of statins in the liver (e.g., itraconazole, erythromycin). Drug interactions can thus significantly increase the risk associated with statin therapy. Oral bioavailability of the statins varies considerably. Besides the absolute rate of oral bioavailability, it is important to know the relative difference between intestinal absorption rate and rate of oral bioavailability in order to assess the potential for drug-drug interactions. Statins that are not metabolized by a single cytochrome P450 isoenzyme, and have a high bioavailability, are the least prone to drug interactions.
Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids (2004)

Uterine leiomyomas are prevalent estrogen-responsive clonal tumors, but the specific genetic alterations that contribute to their development have not been elucidated. To identify genes involved in the formation of leiomyomas, we used global expression profiling to compare clonal tumors with normal myometrium. Contrary to expectation, genes involved in estrogen action were not differentially expressed between leiomyoma and normal myometrium. Genes encoding extracellular-matrix proteins were prominently featured, suggesting their involvement in formation of a myofibroblast phenotype. Analysis of the extracellular matrix in the leiomyomas revealed a disordered collagen fibril orientation. Expression of the collagen-binding protein dermatopontin was found to be consistently decreased in leiomyoma by both reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time RT-PCR (mean underexpression = 9.41-fold) regardless of leiomyoma size, leiomyoma location, patient race, and patient age. This expression pattern was observed in 11 subjects and a total of 23 leiomyoma:myometrium pairs. Decreased expression of dermatopontin was also associated with keloid formation, a fibrotic disease that shares epidemiologic similarities with leiomyoma. Immunohistochemical studies of leiomyomas and keloids demonstrated reduced levels of dermatopontin in both tissues. In addition, ultrastructural analysis revealed that the orientation of the collagen fibrils in the keloid tissues strongly resembled that in the leiomyomas. Reduction in dermatopontin was associated with an increase in transforming growth factor-beta3 (TGFB3) mRNA levels in leiomyomas, whereas other genes involved in dermatopontin signaling were not differentially expressed. These findings suggest that leiomyoma development involves a myofibroblast cell phenotype characterized by dysregulation of genes encoding extracellular-matrix proteins. In particular, decreased expression of dermatopontin represents a molecular link between the leiomyoma and keloid phenotypes.
Absolute ranging using frequency combs (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. C. Swann, I. Coddington, and N. R. Newbury, "Absolute ranging using frequency combs," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper CMB3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Glass ionomer cements used as bonding materials for metal orthodontic brackets. An in vitro study (1991)

The forces required to debond orthodontic brackets on human teeth were studied in vitro. The brackets were bonded with different glass ionomer cements (GICs), and a composite resin (Concise). The shear force required to remove the brackets was recorded at different time intervals after bonding. The bond strength was considerably lower for the GICs compared with brackets bonded with the composite resin, at all time intervals that were studied. Moreover, the bond strength increased more slowly for the GICs compared with the resin. Different GICs displayed a varying setting time. The bonding strength of GICs increased more than 50 per cent between 10 and 20 minutes setting time.
Survival rates and properties of sickle cell anemia red cells treated with nitrogen mustard. (1987)

A machine for the extracorporeal delivery of covalent anti-sickling agents has been described by Babb and coworkers and this therapeutic modality has been found feasible by others. We report here, further evaluation of nitrogen mustard (HN2), for possible use in the extracorporeal therapy of sickle cell anemia. Heparinized aliquots of whole blood from three patients with sickle cell disease were treated extra-corporeally with HN2 (0.65 mg/ml); the excess HN2 was neutralized with thiosulfate, and the blood was returned to the donor after labelling with 51Cr. HN2 produced an average 51Cr T1/2 which was 160% of control values. Fractionation of labelled red cells into different densities (ages) revealed that the main effect of HN2 was on the younger cell population which was characterized by a 51Cr T1/2 increase of 300% over the untreated blood. Further, "in vitro" studies were conducted to establish the effects on the SS red cells that could be expected from the treatment with HN2 at the concentrations used. Solubility determination (Csat) of deoxy hemoglobin S gels demonstrated that HN2 markedly inhibited the polymerization of HbS, was significantly more effective than potassium cyanate, and is among the most potent anti-sickling agents thus far reported. The viscosity of deoxygenated sickle red cells in a cone plate viscometer was markedly reduced by HN2, and hemodynamic studies using the microvasculature of an isolated rat mesoappendix demonstrated a reduction of peripheral resistance and an increase in flow rate when deoxygenated sickle cells pre-treated with HN2 were tested. At the highest concentration of HN2 (2 mg/ml), the peripheral resistance and the flow rates of deoxygenated cells attained levels found with oxygenated sickle blood. O2 affinity was partially corrected in the HN2 treated HbSS red cells. -SH reactivity of the red cell membrane was not affected by HN2. Among the added advantages of HN2 for extra-corporeal use is its rapid reaction rate, the lack of significant change of the O2 equilibrium at the concentration tested and the fact that the unreacted compound can be readily detected and neutralized. For these reasons HN2 is well suited for extra-corporeal treatment of sickle cell anemia for those patients with a severe form of the disease.
Electrochemical Behavior of Sodium Tungsten Bronze Electrodes in Acidic Media (1973)

The electrochemical behavior of sodium tungsten bronze electrodes has been examined in helium‐saturated . Several techniques have been employed, e.g., steady‐state polarization, potentiodynamic scanning, galvanostatic charging, and open‐circuit decay of electrode potential. New data involving potential‐pH, rotating‐ disk, and thermogravimetric measurements on the sodium tungsten bronze electrode are also reported.
Vertical profiling of atmospheric refractivity from ground‐based GPS (2002)

Atmospheric refractivity is typically estimated in situ from radiosonde measurements, which are expensive and may undersample the spatial and temporal variability of weather phenomena. We estimate refractivity structure near San Diego, California, using ray propagation models to fit measured GPS tropospheric delays in a least squares metric. We evaluate the potential and the limitations of ground‐based GPS measurements for characterizing atmospheric refractivity, and we compare refractivity structure estimated from GPS sensing with that measured by nearby radiosondes. The results suggest that ground‐based GPS provides significant constraint of inhomogeneous atmospheric refractivity, despite certain fundamental limitations of ground‐based measurements. Radiosondes typically are launched just a few times daily. Consequently, estimates of temporally and spatially varying refractivity that assimilate GPS delays could substantially improve over estimates using radiosonde data alone.