gebhart/patrepeval huggingface dataset:
Bcl2, p53 and clinical outcome in a series of 138 operable breast cancer patients. (2000)

Medical oncologists are increasingly interested in identifying reliable prognostic factors for breast cancer in order to distinguish subsets of breast cancer patients and to optimize therapeutic approaches. Among them, the p53 tumor suppressor gene and bcl2 protein continue to be extensively studied, but their role remains to be defined. Moreover the mechanism of action by which they affect cell kinetics has to be clarified, particularly with respect to the balance between cell proliferation and apoptosis. We studied 138 operable breast cancer patients in order to verify the relationships of p53 and bcl2 proteins with better known clinicopathological features and their impact on the clinical outcomes of relapse-free survival (RFS) and overall survival (OS). Our data indicated a significant relationship between bcl2 expression and steroid receptor positive status, wild-type p53 and low proliferative index. Mutant p53 accumulation was found to be related to the absence of steroid receptors and high proliferation. Both were significant markers of better prognosis in univariate analysis. Multivariate analysis confirmed the favorable impact of bcl2 on both RFS and OS. On the contrary, we failed to observe any prognostic role for p53 status. We describe herein an independent favorable prognostic impact for patients with positive bcl2 expression that appears to be worthy of larger confirmatory study. On the contrary, our series seems to confirm the decreasing prognostic relevance of p53 in clinical practice.
Inductance formulas for circular and square coils (1982)

Some simple inductance formulas are given for a circular or square coil of any shape ratio. Each one represents a continuous transition between the extremes of a long coil and a short coil. A unique case is a cubic coil whose inductance is 2/3 the reference value based on area/length. For any shape, the relative error is very small and is stated. The theoretical formulas are given for comparison.
THE CLASSIFICATION OF GILGAIED SOILS: SOME EVIDENCE FROM NORTHERN IRAQ (1959)

Summary The discrepancies between the classifications of McGarity and Hallsworth et al. are summarized and confirmed with later descriptions by other writers. Further evidence from Northern Iraq shows that gilgai occurs which forms a transition from normal to‘tank’form in several topographic types. A further form of depression gilgai is described completing the four possible combinations of the lattice‐A, wavy, and normal gilgai of Hallsworth et al. Depression forms from the limit of the area in which gilgai occurs are described. A new classification into gilgai types (based on topography and dominance of shelf and puff) and varieties (based on the nature of the puff and the size of puffs and channels) is suggested.
miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7 (2016)

MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level, and play pivotal roles in cancer development and progression. miR-100 has been reported to be significantly downregulated in a variety of cancers, including esophageal cancer. However, the role of miR-100 in human esophageal cancer has not been fully elucidated. We demonstrated that overexpression of miR-100 in esophageal cancer cells markedly inhibited cell proliferation, migration and invasion as well as tumor growth. We subsequently showed that CXCR7 is a direct target gene of miR-100. Our results indicated that miR-100 plays a tumor-suppressor role in esophageal cancer and suggest its potential application for esophageal cancer treatment.
Key Performance Indicators for 5G network slicing (2019)

Network slicing technology will influence the way in which new networking solutions will be designed and operated. So far, network slicing is often linked with 5G networks, but this approach can be used to deploy any communications network(s) over a common infrastructure. The concept is still a subject of intensive research and standardization. From the point of view of network or service operator, it is necessary to define fundamental quantitative indicators for performance evaluation of the network slicing. Such parameters are often called Key Performance Indicators (KPIs). Network slicing KPIs should deal with network slicing run-time and life-cycle management and orchestration. The paper proposes a set of KPIs for network slicing taking into account the 5G network specifics.
Capped cyclodextrin (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCapped cyclodextrinIwao Tabushi, Kazuhiro Shimokawa, Nobuaki Shimizu, Hiroko Shirakata, and Kahee FujitaCite this: J. Am. Chem. Soc. 1976, 98, 24, 7855–7856Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November 1976https://pubs.acs.org/doi/10.1021/ja00440a083https://doi.org/10.1021/ja00440a083research-articleACS PublicationsRequest reuse permissionsArticle Views720Altmetric-Citations148LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tris(trifluoromethanesulfonyl)methide (“Triflide”) Anion:  Convenient Preparation, X-ray Crystal Structures, and Exceptional Catalytic Activity as a Counterion with Ytterbium(III) and Scandium(III) (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTTris(trifluoromethanesulfonyl)methide ("Triflide") Anion: Convenient Preparation, X-ray Crystal Structures, and Exceptional Catalytic Activity as a Counterion with Ytterbium(III) and Scandium(III)Francis J. Waller, Anthony G. M. Barrett, D. Christopher Braddock, Dorai Ramprasad, R. Murray McKinnell, Andrew J. P. White, David J. Williams, and Richard DucrayView Author Information Air Products and Chemicals, Inc., 7201 Hamilton Boulevard, Allentown, Pennsylvania 18195-1501 and Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, UK SW7 2AY Cite this: J. Org. Chem. 1999, 64, 8, 2910–2913Publication Date (Web):March 26, 1999Publication History Received20 January 1998Published online26 March 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/jo9800917https://doi.org/10.1021/jo9800917brief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views2103Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Cesium,Metals,Organic reactions,Salts Get e-Alerts
ATPG-based logic synthesis (2002)

The ultimate goal of logic synthesis is to explore implementation flexibility toward meeting design targets, such as area, power, and delay. Traditionally, such flexibility is expressed using "don't cares" and we seek the best implementation that does not violate them. However, the calculation and storing of don't care information is CPU and memory-intensive. In this paper, we give an overview of logic synthesis approaches based on techniques developed for Automatic Test Pattern Generation (ATPG). Instead of calculating and storing don't cares explicitly, ATPG-based logic synthesis techniques calculate the flexibility implicitly. Low CPU and memory usage make those techniques applicable for practical industrial circuits. Also, the basic ATPG-based logic level operations create predictable, small layout perturbations, making an ideal foundation for efficient physical synthesis. Theoretical results show that an efficient, yet simple add-a-wire-and-remove-a-wire operation covers all possible complex logic transformations.
Stereospecific Conversion of 1-Aminocyclopropanecarboxylic Acid to Ethylene by Plant Tissues (1982)

Inasmuch as the molecule of 1-aminocyclopropanecarboxylic acid (ACC) possesses reflective symmetry but lacks rotational symmetry, the two chemically alike methylene groups can be distinguished by a stereospecific enzyme. To determine whether ACC conversion to ethylene by plant tissues proceeds in a stereospecific fashion, the four stereoisomers of 1-amino-2-ethylcyclopropanecarboxylic acid (AEC) were administered to postclimacteric apple (Malus sylvestris Mill., var. Golden Delicious), excised preclimacteric cantaloupe (Cucumis melo L., var. reticulatis Naud cv. PMR-45), and etiolated mung bean (Vigna radiata L., Wilczek, var. Berken) hypocotyls. In each case (1R,2S)-AEC was the preferred substrate yielding 1-butene. In contrast, all AEC isomers were converted equally well to butene by chemical oxidation using NaOCl. Both ACC and AEC appear to be substrates for the same enzyme since both reactions are inhibited in parallel by N(2) or Co(2+), both reactions are induced in parallel by excision, and when both substrates are present simultaneously each will act as an inhibitor with respect to the other. The aforementioned observations indicate that ACC is stereospecifically converted to ethylene. For AEC to be the most active precursor of 1-butene, the ethyl substituent should be trans to the carboxyl group and the pro-(S) methylene group should be unsubstituted. This observation leads to the suggestion that the enzyme interacts with amino, carboxyl, and pro-(S) methylene groups, a configuration corresponding to a l-amino acid. This view is consistent with the observation that the l-forms of alanine and methionine inhibit the conversion of ACC to ethylene more than the corresponding d-amino acids in the mung bean hypocotyl system.
Dual simulated childbirth injury delays anatomic recovery (2008)

A dual childbirth injury model, including vaginal distension (VD) and pudendal nerve crush (PNC), may best represent the injuries seen clinically. The objective of this study was to investigate urethral function, anatomy, and neurotrophin expression after several simulated childbirth injuries. Groups of 140 rats underwent PNC, VD, PNC+VD, or neither (C). Four days after injury, all injury groups had significantly decreased leak-point pressure (LPP) compared with C rats. Ten days after injury, LPP in PNC and PNC+VD rats remained significantly lower than C rats. Three weeks after injury, LPP in all injury groups had recovered to C values. Histological evidence of injury was still evident in the external urethral sphincter (EUS) after VD and PNC+VD 10 days after injury. Three weeks after injury, the EUS of PNC+VD rats remained disrupted. One day after VD, brain-derived neurotrophic factor (BDNF) expression in the EUS was reduced, while neurotrophin-4 (NT-4) and nerve growth factor (NGF) expression was unchanged. BDNF, NT-4, and NGF expression was dramatically upregulated in the EUS after PNC. After PNC+VD, NGF expression was upregulated, and BDNF and NT-4 expression was upregulated somewhat but not to the same extent as after PNC. Ten days after injury, PNC+VD had the least number of normal nerve fascicles near the EUS, followed by PNC and VD. Twenty-one days after injury, all injury groups had fewer normal nerve fascicles, but without significant differences compared with C rats. PNC+VD therefore provides a more severe injury than PNC or VD alone.
Five-stage free-space optical switching network with field-effect transistor self-electro-optic-effect-device smart-pixel arrays (1994)

The design, construction, and operational testing of a five-stage, fully interconnected 32 × 16 switching fabric by the use of smart-pixel (2, 1, 1) switching nodes are described. The arrays of switching nodes use monolithically integrated GaAs field-effect transistors, multiple-quantum-well p-i-n detectors, and self-electro-optic-device modulators. Each switching node incorporates 25 field-effect transistors and 17 p-i-n diodes to realize two differential optical receivers, the 2 × 1 node switching logic, a single-bit node control memory, and one differential optical transmitter. The five stages of node arrays are interconnected to form a two-dimensional banyan network by the use of Fourier-plane computer-generated holograms. System input and output are made by two-dimensional fiber-bundle matrices, and the system optical hardware design incorporates frequency-stabilized lasers, pupil-division beam combination, and a hybrid micro-macro lens for fiber-bundle imaging. Optomechanical packaging of the system ut lizes modular kinematic component positioning and active thermal control to enable simple rapid assembly. Two preliminary operational experiments are completed. In the first experiment, five stages are operated at 50 Mbits/s with 15 active inputs and outputs. The second experiment attempts to operate two stages of second-generation node arrays at 155 Mbits/s, with eight of the 15 active nodes functioning correctly along the straight switch-routing paths.
A low voltage capillary microgripper using electrowetting (2009)

We present a new microgripper utilizing a liquid droplet to pick up and release micro objects. Lifting force is evolved from a liquid bridge formed between the gripper surface and an object. Electrowetting is used to dynamically change the capillary lifting forces and enable object release. The driving voltage is applied to a pair of coplanar interdigitated electrodes. A Barium Strontium Titanate (BST) insulation layer is used to lower the driving voltage. Experiments indicated that the lifting forces can be as high as 213 muN at a driving voltage of 28 V. Experiments also demonstrated the picking-up and releasing of micro glass beads.
PASSporT: Personal Assertion Token (2018)

This document defines a method for creating and validating a token
that cryptographically verifies an originating identity or, more
generally, a URI or telephone number representing the originator of
personal communications. The Personal Assertion Token, PASSporT, is
cryptographically signed to protect the integrity of the identity of
the originator and to verify the assertion of the identity information
at the destination. The cryptographic signature is defined with the
intention that it can confidently verify the originating persona even
when the signature is sent to the destination party over an insecure
channel. PASSporT is particularly useful for many personal-
communications applications over IP networks and other multi-hop
interconnection scenarios where the originating and destination
parties may not have a direct trusted relationship.
Adaptive Motion Estimation and Mode Decision Strategy for H.264 Encoder (2006)

In order to reduce the heavy computation burden of H.264 encoder, an adaptive scheme is proposed to jointly optimize motion estimation and mode decision process. The proposed algorithm utilizes the spatial homogeneity of video object's textures, the motion activity information and the statistical characters on reference frame selection in motion estimation, to effectively skip unnecessary modes and reference frames. Experimental results show that the proposed method achieves a reduction of 40-80% encoding time, with a negligible PSNR loss and bit-rate increase
Control of kidney size by sex hormones: possible involvement of glucosylceramide (1992)

Because androgenic hormones produce an increase in kidney size and the production of kidney glycosphingolipids and because the level of tissue glucosylceramide (GlcCer) has been implicated as a modulator of organ size, we measured the activities of two enzymes in mouse kidney that (in part) determine the level of this glycolipid. GlcCer synthase was found to rise in specific activity with age and increased kidney size, whereas GlcCer glucosidase was found to decrease with age; both enzyme changes act to elevate the level of kidney GlcCer and point to the level of this lipid as a determinant of kidney size. The increase in synthase was especially rapid in male kidney, consistent with the more rapid growth of male kidney. Testosterone injection into both males and females produced elevated levels of GlcCer synthase, decreased levels of the hydrolase, and more rapid growth. Injection of 17 beta-estradiol, which produced slow or negative kidney growth, caused the synthase activity to decrease in female mouse kidney and the glucosidase activity to rise in both sexes. Thus the changes in kidney size produced by the two hormones paralleled the changes in GlcCer level predicted by the hormone effects on the two enzymes. In liver, estradiol produced increases in both enzymes but only the male liver increased in size. Testosterone did not affect the liver. The testes grew with age but the activities of both enzymes decreased.
Chapter 46 Diffusion media materials and characterisation (2015)

Polymer electrolyte fuel cell (PEFC) stacks usually employ bipolar plates with channels on either side for the distribu-tion of reactants over the electrode surfaces. Figure 1 shows the cross-section of a small section from such a PEFC. At
Pre-reconstruction three-material decomposition in dual-energy CT (2009)

It is of clinical interest to quantify the concentration of materials in a three-component mixture with known chemical
compositions, such as bone-mineral density (BMD) in a trabecular bone composed of calcium hydroxyappitite (CaHA),
yellow- and red-marrow, and iron content in the liver composed of soft tissue, fat, and iron. Both pre- and postreconstruction
dual-energy CT methods have been used to achieve this goal. The 
pre-reconstruction method is more
accurate due to the elimination of beam-hardening artifacts. After obtaining the equivalent densities of the two basis
materials, however, it is unclear how to accurately estimate the concentration of each material in the presence of the third
material in the mixture. In this work, we present a pre-reconstruction three-material decomposition method in dualenergy
CT to quantify the concentration of each material in a 
three-component mixture with known chemical
compositions. This method employs a specific physical constraint on the equivalent densities of the two basis materials
obtained from the conventional basis-material decomposition. We evaluated this method using simulation studies on two
types of three-component mixtures: bone-water-fat and 
Iron-water-CaHA. The results demonstrated that an accurate
estimation of the concentration for each material can be achieved with the proposed method.
Observation of giant magnetoresistance in Ag-Ni-Fe alloy films (1993)

We report the observation of a large magnetoresistance in as-deposited co-sputtered Ag-Ni-Fe films. The size of the magnetoresistance has been measured as a function of the film composition. Measurement of the samples’ hysteresis indicates that smaller Ag concentrations result in regions of the films becoming ferromagnetically coupled while greater concentrations result in the formation of a superparamagnetic state. Crystallographic evidence obtained using x-ray diffraction shows the samples to have the crystal structure of a contracted Ag lattice possibly caused by the inclusion of Ni and Fe.
The Study on the Modulor as Harmonious Measure by Le Corbusier (1997)

Le Corbusier had developed the Modulor replacing the Regulating Lines in the 1930's and 1940's. The lines can not produce lyrical ideas or creational concept but make plastic dimension pure only to keep in balance. First, the Grid of Proportions was developed and then the Modulor 1. The Modulor originated in one square, double square, the two golden means added or subtracted, the place of the right angle, human dimension, the Fibonacci series and divided Red series and Blue series. He developed the Modulor 2 for a reconciliation between the foot-and-inch system and the metre. As Corbusier devoted himself to a social and industrial problem, he was sure that a transcendental universality be in cosmos including a human being. His dream was to creat a orderly and harmonious utopia. What intrinsic harmony between Cosmos, nature and a human being be realized by mathematic order was the reason he hinted himself to the proportion.
Sequential transmission using noiseless feedback (1963)

The presence of a feedback channel makes possible a variety of sequential transmission procedures, each of which can be classified as either a block-transmission or a continuous-transmission scheme according to the way in which information is encoded for transmission over a noisy forward channel. A sequential continuous-transmission system employing a binary symmetric forward channel (but which is suitable for use with any discrete memoryless forward channel) and a noiseless feedback channel is described. Its error exponent is shown to be substantially greater than the optimum block-code error exponent at all transmission rates less than channel capacity. The average value and the first-order probability distribution of the effective constraint length, found by simulating the system on an IBM 709 computer, are also given.
Automatic network traffic classification (2013)

\n\t\t\t\t\tThe thesis addresses a number of critical problems in regard to fully automating the process of network traffic classification and protocol identification. Several effective solutions based on statistical analysis and machine learning techniques are proposed, which significantly reduce the requirements for human interventions in network traffic classification systems.\n\t\t\t\t