gebhart/patrepeval huggingface dataset:
Altered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque-type psoriasis (2009)

These data point to significant differences in the blood and lymphatic vascular transcriptome between the clinically normal-appearing skin of patients with psoriasis and the skin of volunteers without psoriasis.
430. Chemistry of the inter-halogen compounds. Part I. The reaction of bromine trifluoride with metallic halides (1948)

A. G. Sharpe and H. J. Emeléus, J. Chem. Soc., 1948, 2135 DOI: 10.1039/JR9480002135
Correlation of total (TSA) and lipid and bound (LSA) sialic acid levels with cytology of cyst or body fluids in cancer patients. (1992)

In this preliminary study, aiming at the early diagnosis or the confirmation of neoplastic spreading, the levels of sialic acid (TSA and LSA, total sialic acid and "lipid bound" sialic acid) were measured and correlated with the corresponding cytologic findings in 111 body or cystic fluid samples taken from patients with suspected or confirmed cancer. The samples were classified according to the body fluid origin: peritoneal (35), breast cyst (22), pleural (21), thyroid gland cyst (5), renal cyst (5), ovarian cyst (6), bronchial washing (3), douglasic cavity (3) and various other origins (11). It was found that 32.43% of the samples were TSA positive, 44.14% LSA positive, 20.75% cytologic and 8.49% cytology suspect (positive + suspect = 29.24%). Thus, the combination of a tumor biomarker with the corresponding cytology of the body fluid gives the best possible results, as regards both the confirmation of positive cytology and the detection of possible metastases, as well as the monitoring of the disease after treatment.
Enzyme-capture assay for rapid detection of Escherichia coli in oysters (1989)

Enzyme-capture assays (ECAs) for Escherichia coli beta-D-glucuronidase (GUD) were performed directly from 24-h gas-positive lauryl tryptose broth (LTB) fermentation tubes that had been inoculated with oyster homogenate seeded with E. coli. The LTB-ECA method yielded results in 1 day that were equivalent to those obtained in 2 days by an LTB and EC-4-methylumbelliferyl-beta-D-glucuronide (EC-MUG) method. Overall, 62 of 64 (97%) positive EC-MUG broths from which E. coli was isolated were correctly identified by ECA. Of 61 LTB tubes identified as GUD negative by ECA, 59 were confirmed to be free of E. coli by using EC-MUG; thus, the false-negative rate was approximately 3%. Polyclonal antibodies prepared against E. coli GUD reacted only with GUDs of E. coli, Escherichia vulneris, and Shigella sonnei. The antibodies did not react with GUDs from Flavobacterium spp., Staphylococcus spp., Yersinia enterocolitica, shellfish, or bovine liver. The GUD ECA test, when used in conjunction with the most-probable-number technique, was a rapid method for E. coli enumeration in oysters.
The Lower Limit of Cerebral Blood Flow Autoregulation Is Increased with Elevated Intracranial Pressure (2009)

In this atraumatic, elevated ICP model in piglets, the LLA had a positive correlation with ICP, which suggests that compensating for an acute increase in ICP with an equal increase in ABP may not be sufficient to prevent cerebral ischemia.
Speech Translation with Phrase Based Stochastic Finite-State Transducers (2007)

Stochastic finite-state transducers constitute a type of word-based models that allow an easy integration with acoustic model for speech translation. The aim of this work is to develop a novel approach to phrase-based statistical finite-state transducers. In this work, we explore the use of linguistically motivated phrases to build phrase-based models. The proposed phrase-based transducer has been tested and compared to a word-based equivalent machine, yielding promising results in the reported preliminary text and speech translation experiments.
Phagocytosis and ATP Levels in Alveolar Macrophages during Acute Hypoxia (1992)

Pulmonary alveolar macrophages (PAM) function as phagocytes of inhaled particulate matter and microorganisms at the air-tissue interface of lung alveoli. Changes in cellular ATP concentrations ([ATP]) and phagocytic function during acute hypoxia may be important in conditions associated with low alveolar O2. We proposed that acute hypoxia would decrease phagocytosis and reduce [ATP] in freshly isolated PAM. Phagocytic function (fluorescent microscopic technique determining percent phagocytosis in live cells) was monitored by recording uptake and retention of glutaraldehyde-fixed red blood cells (GRBC) in isolated rabbit PAM during acute incubations in air (20% O2) or hypoxia (1.7% O2). Macrophage [ATP] were determined spectrophotometrically. Acute hypoxia for 30 to 150 min decreased phagocytic function 30 to 56% in PAM without significantly affecting cell adherence and viability. Pre-exposure of PAM to hypoxia before addition of GRBC resulted in an even greater reduction in phagocytosis (97% decrease by 30 min), and recovery of phagocytic function occurred 60 to 90 min after returning PAM to air. The cellular retention of phagocytosed GRBC (percentage of PAM with GRBC and number of GRBC/PAM) was reduced 30% by 1 h of hypoxia. Compared with [ATP] of PAM in air, [ATP] of PAM exposed to hypoxia were reduced 55 and 35% at 30 and 60 min, respectively. Compared with [ATP] of cells with GRBC in air at 0 and 30 min, PAM with GRBC in hypoxia for 30 min had, respectively, 61 and 40% lower [ATP]. By 60 min with GRBC, PAM [ATP] in air and hypoxia were similar but were 50% lower than [ATP] at time 0.(ABSTRACT TRUNCATED AT 250 WORDS)
Electronic ballast for fluorescent lamps (1993)

A frequency-domain analysis is given for a Class D voltage-switching power inverter with a load resistance connected in parallel with a resonant capacitor. Using the fundamental component approximation, design equations are derived to provide easy-to-use design tools. The inverter is inherently short-circuit-proof, but cannot operate safely with an open circuit at the resonant frequency. Safe operation with an open circuit can be achieved if the operating frequency is sufficiently lower or higher than the resonant frequency. Experimental results are given for two F40 fluorescent lamps connected in series, using MTP5N40 MOSFETs. The operating frequency was 50 kHz at full power and 70 kHz at 20% of full power. At full power, the efficiency of the Class D inverter was 95.6% and the efficiency of the power factor corrector was 93%. The overall efficiency of the ballast was 89.4% at full power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Circulating tumor cells versus tumor-derived cell-free DNA: rivals or partners in cancer care in the era of single-cell analysis? (2013)

Cancer presents a problem of complexity. Although our understanding of tumor biology has increased expo nen­ tially over recent decades, and we have many available technologies to characterize tumors, whether and when an individual cancer will metastasize remains unknown. Moreover, if metastases do occur, their molecular features may not match those of the primary tumor or other metastases. Ideally, to guide treatment decisions, all micro­ and macrometastases would be identifi ed, biopsied and molecularly analyzed, but this is not currently possible, practical or safe. Th us, investigations are now focusing on blood­based assays that detect and characterize circulating tumor cells or circulating tumor DNA (a component of cell­free DNA). Th ese minimally invasive, real­time ‘liquid biopsies’ can be performed at multiple intervals to monitor disease and tailor cancer therapy. It is as yet unknown whether these represent com­ peting technologies or if they should be used together. Tumors are heterogeneous and tend to change over
ENANTIOFACE-DIFFERENTIATING HYDROGENATION OF 2-ALKANONES OVER MODIFIED RANEY NICKEL (1985)

Abstract 2-Octanone was hydrogenated over tartaric acid-NaBr-modified Raney nickel in the presence of pivalic acid at various temperatures. The hydrogenation at 50–60 °C gave the best result with regard to the optical yield. Almost 80% of the optical yields were attained in the hydrogenations of various 2-alkanones.
Recent Improvements in Beam Diagnostic Instrumentation (1979)

In high-current machines, such as LAMPF and the envisioned Hanford Engineering Development Laboratory (HEDL) Fusion Materials Irradiation Test (FMIT) Facility linac, hands-on maintenance is desired. Beam spill must be kept extremely low; therefore, attention must be given to beam fringes (tails). Beam matching to the structure becomes increasingly important. We describe equipment capable of accurately measuring transverse beam profiles over a range spanning more than four orders of magnitude and longitudinal phase profiles over ranges spanning more than three orders of magnitude. Errors in 100-MeV transverse emittance measurements are explored and experimental emittance measurements made with three different methods are compared. Advantages of one nondestructive method are developed.
Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets (2010)

These studies characterize the insulinotropic effects of an early-stage, small molecule GLP-1 receptor agonist and provide compelling evidence to support pharmaceutical optimization.
Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. (1982)

The AtT-20/D16-16 mouse pituitary tumor cell secretes corticotropin (ACTH) in response to corticotropin-releasing factor (CRF), (-)-isoproterenol, and vasoactive intestinal peptide (VIP). These responses are associated with a rapid increase in cyclic AMP formation. Somatostatin (SRIF) markedly decreases the stimulatory effect of CRF, (-)-isoproterenol, and VIP on both cyclic AMP formation and immunoreactive ACTH secretion. Forskolin and cholera toxin, adenylate cyclase activators, also stimulate cyclic AMP formation and ACTH secretion in AtT-20 cells and these responses are all inhibited by SRIF. The ACTH secretory responses to melittin and to the calcium ionophore A23187, neither of which increases cyclic AMP in AtT-20 cells, were not inhibited by SRIF. SRIF did not affect the binding of a tritiated beta-adrenergic receptor antagonist to AtT-20 membranes nor did it decrease basal cyclic AMP formation even in the presence of excess phosphodiesterase inhibitor, indicating that the reduction of cyclic AMP levels by SRIF did not involve either an interference with beta-adrenergic agonist binding to receptors or stimulation of cyclic AMP degradation. These results indicate that the inhibition of CRF-, (-)-isoproterenol-, and VIP-stimulated ACTH secretion by SRIF may be regulated by its inhibitory action on adenylate cyclase.
The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB (2016)

Expression of the stress-induced ligands MICA, MICB and ULBP 1-6 are up-regulated as a cellular response to DNA damage, excessive proliferation or viral infection; thereby, they enable recognition and annihilation by immune cells that express the powerful activating receptor NKG2D. This receptor is present not exclusively, but primarily on NK cells. Knowledge about the regulatory mechanisms controlling ULBP expression is still vague. In this study, we report a direct interaction of the oncogenic RNA binding protein (RBP) IMP3 with ULBP2 mRNA, leading to ULBP2 transcript destabilization and reduced ULBP2 surface expression in several human cell lines. We also discovered that IMP3 indirectly targets MICB with a mechanism functionally distinct from that of ULBP2. Importantly, IMP3-mediated regulation of stress-ligands leads to impaired NK cell recognition of transformed cells. Our findings shed new light on the regulation of NKG2D ligands and on the mechanism of action of a powerful oncogenic RBP, IMP3.
Turnover of Carbohydrate-Rich Vegetal Matter During Microaerobic Composting and After Amendment in Soil (2011)

We propose that microaerobic composting (MC) can be used to decompose vegetal matter with a short turnover time and large carbon (C) recycling potential. We used a novel method for measuring the degree of fragmentation of water-insoluble acid-soluble (WIAS) polysaccharides as a proxy in tracking their relative degree of degradation (i.e., fragmentation endpoint index). Oak leaves and food scrap processed by MC reached a fragmentation end point within 2 weeks. After amending the MC products into soil, the half-life of the polysaccharide residues was ~6-7 times longer (~100-110 days) than that measured during MC. The main products given up during MC were volatile organic acids (VOAs), alcohols and soluble carbohydrates in the compost tea, and CO(2). These products accounted for about 2% of the initial carbon in the feedstock. Very small amounts of VOAs, particularly butyric acid, were formed in the amended soil. Based on a residence time of materials in fermentors of 2 weeks, a ~100-m(3) capacity MC facility could process 2,000-4,000 metric tons of vegetable matter amended in ten hectares of arable land per year.
Cellular signaling in macrophage migration and chemotaxis (2000)

Whereas most cells in adult tissues are fixed in place by cell junctions, leukocytes are motile and able to migrate actively through the walls of blood vessels into surrounding tissues. The actin cytoskeleton of these cells plays a central role in locomotion, phagocytosis, and the regulation of cell shape that are crucial elements of neutrophil and monocyte/macrophage function. This review will concentrate on how macrophages in particular control the actin cytoskeleton to generate cell movement and the shape changes required for chemotaxis. It has recently become evident that a complex of seven proteins known as the Arp2/3 complex regulates the assembly of new actin filament networks at the leading front of moving cells. Proteins of the Wiskott-Aldrich Syndrome Protein (WASP) family bind directly to the Arp2/3 complex and stimulate its ability to promote the nucleation of new actin filaments. Upstream of the WASP family proteins, receptor tyrosine kinases, G-protein-coupled receptors, phosphoinositide-3-OH kinase (PI 3-kinase), and the Rho family of GTPases receive and transduce the signals that lead to actin nucleation through WASP-Arp2/3 action. Although many gaps remain in our understanding, we are now in a position to consider completing signaling pathways that are initiated from outside the cell to the actin rearrangements that drive cell motility and chemotaxis.
Diazepam, Propranolol and their Combination in the Management of Chronic Anxiety (1981)

The therapeutic benefit of combining propranolol with diazepam over either of these drugs given alone was tested in a placebo-controlled crossover study with twenty-four chronically anxious out-patients. The combination was generally more effective than diazepam. Diazepam was more effective than placebo or propranolol. A reduction in the resting pulse rate by propranolol of more than 7.5 beats per minute resulted in a greater therapeutic response to this drug, alone and in combination. Lesser degrees of pathology responded better to treatment. Psychological factors in treatment showed themselves to be important in moderating pharmacological response. Chronically anxious patients generally derived little benefit from continued anti-anxiety treatment.
Steel Converter Slag as a Raw Material for Precipitation of Pure Calcium Carbonate (2008)

In this work we study the possibility of utilizing steel converter slag, a byproduct of steel manufacturing, for production of pure calcium carbonate. The dissolution of calcium from steel converter slag by using acetic acid as a solvent and the precipitation of pure calcium carbonate from the resulting solution were experimentally investigated. It was found that, while strong solutions of acetic acid dissolve most of the calcium from the slag, weak acetic acid solutions dissolve calcium selectively. Precipitation of any substantial amount of calcium carbonate was found to require the addition of sodium hydroxide. Calcium conversion from the solution into the precipitate was as high as 86%, and the purity of the precipitate was over 99%. The calcium carbonate particles produced at low temperatures were found to have rhombohedral particle shapes, a very high brightness (98.7%), and a small particle size (mean value of 0.6 μm).
Review Robot Scientists for autonomous scientific discovery (2010)

We review the main components of autonomous scientific discovery, and how they lead to the concept of a Robot Scientist. This is a system which uses techniques from artificial intelligence to automate all aspects of the scientific discovery process: it generates hypotheses from a computer model of the domain, designs experiments to test these hypotheses, runs the physical experiments using robotic systems, analyses and interprets the resulting data, and repeats the cycle. We describe our two prototype Robot Scientists: Adam and Eve. Adam has recently proven the potential of such systems by identifying twelve genes responsible for catalysing specific reactions in the metabolic pathways of the yeast Saccharomyces cerevisiae. This work has been formally recorded in great detail using logic. We argue that the reporting of science needs to become fully formalised and that Robot Scientists can help achieve this. This will make scientific information more reproducible and reusable, and promote the integration of computers in scientific reasoning. We believe the greater automation of both the physical and intellectual aspects of scientific investigations to be essential to the future of science. Greater automation improves the accuracy and reliability of experiments, increases the pace of discovery and, in common with conventional laboratory automation, removes tedious and repetitive tasks from the human scientist. Review Towards the full automation of scientific discovery
Epithelial ovarian cancer and combined oral contraceptives. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. (1989)

The relationship between use of combined oral contraceptives and risk of epithelial ovarian cancer was investigated in a hospital-based case-control study conducted from 1979-1986 in seven countries. Three hundred and sixty-eight women with histologically confirmed epithelial ovarian cancer were compared to 2397 hospital controls matched for age, study centre, hospital and year of interview. The relative risk (RR) in women who ever used combined oral contraceptives, controlling for the confounding effect of number of pregnancies, was 0.75 (95% confidence interval (Cl) 0.56, 1.01). The relative risk decreased with increasing duration of oral contraceptive use and with increasing time since cessation of use. Except for mucinous tumours, oral contraceptive use was associated with lower risk of all histological subtypes of epithelial ovarian cancer. While the reduced risk associated with oral contraceptive use was present in parous women (RR = 0.85), it was most pronounced in nulliparous women (RR = 0.16). The magnitude of the negative association between oral contraceptives and ovarian cancer in five developing countries (RR = 0.77) was similar to that reported in developed countries.
PaToPa: A Data-Driven Parameter and Topology Joint Estimation Framework in Distribution Grids (2017)

The increasing integration of distributed energy resources calls for new planning and operational tools. However, such tools depend on system topology and line parameters, which may be missing or inaccurate in distribution grids. With abundant data, one idea is to use linear regression to find line parameters, based on which topology can be identified. Unfortunately, the linear regression method is accurate only if there is no noise in both the input measurements (e.g., voltage magnitude and phase angle) and output measurements (e.g., active and reactive power). For topology estimation, even with a small error in measurements, the regression-based method is incapable of finding the topology using nonzero line parameters with a proper metric. To model input and output measurement errors simultaneously, we propose the error-in-variables model in a maximum-likelihood estimation framework for joint line parameter and topology estimation. While directly solving the problem is NP-hard, we successfully adapt the problem into a generalized low-rank approximation problem via variable transformation and noise decorrelation. For accurate topology estimation, we let it interact with parameter estimation in a fashion that is similar to expectation-maximization algorithm in machine learning. The proposed PaToPa approach does not require a radial network setting and works for mesh networks. We demonstrate the superior performance in accuracy for our method on IEEE test cases with actual feeder data from Southern California Edison.
BISULFITE MUTAGENESIS IN BACTERIOPHAGE T4 (1971)

ISULFITE is employed as a preservative in foods and pharmaceuticals. Chemical studies of its interactions with nucleic acid components indicate that it reacts with uracil and cytosine in ways which might be mutagenic ( SHAPIRO and
Studies on the Processing of Krill Sauce (1984)

The Antarctic krill, Euphausia superba, is drawing attention over the world as the largest source of unutilized proteins in the ocean. For the use of krill as a human food, processing conditions of krill sauce by autolysis and/or commercial proteolytic enzyme digestion were examined. The krill was chopped and mixed with equal weight of water, and hydrolyzed by autolysis and/or commercial proteolytic enzyme digestion. The optimal conditions for hydrolysis of krill were , pH 7.0-7.5, 3 hours by autolysis, , pH 6.3, 3hours by bromelain (0.5 %) digestion, and , pH 7.0-7.5, 3 hours by commercial complex enzyme (5 %) digestion, respectively The maximum hydrolyzing rate of protein were 83.2 % by autolysis, 89.7 % by bromelain digestion, 92.7 % by commercial complex enzyme digestion. After krill meat hydrolyzed by autolysis at optimum condition, inactivated at for 20 minutes and filtered with Buchner funnel. Two kinds of products were prepared with krill hydrolysate and preservatives: one contained 10 % of sodium chloride and 0.06 % of benzoic acid and the other 10 % of sodium chloride and 3 % of ethyl alcohol. These products were filled in the sterilized glass bottle and sealed. The pH, volatile basic nitrogen, amino nitrogen, color value (L, a and b values) and viable counts of bacteria were determined during storage at . The results showed that the products could be preserved in good condition during one month at . As a method to reduce the sodium level in krill sauce, it is convinced that sodium chloride could be replaced half in partially by potassium chloride. In the products prepared from krill by autolysis, bromelain or commercial complex enzyme digestion, hypoxanthine and 5'-IMP were abundant among the nucleotides and their related compounds as 15.3-20.4 , dry solid, 2.2-2.5 , dry solid, respectively. The abundant free amino acids were lysine, leucine, proline, alanine and valine. The contents of these amino acids were 67.4 %, 69.4 %, 69.8 % of the total free amino acids of each products. And TMAO, betaine and total creatinine were low in contents. The flavor of krill sauce prepared from krill by autolysis or enzyme digestion was not inferior to that of traditional Kerean soy sauce by sensory evaluation.
CMOS micro-hotplate array design for nanomaterial-based gas sensors (2008)

In this paper we propose novel micro-hotplate arrays for use as nanomaterial-based gas micro sensors. In addition to the better selectivity offered by conventional micro-hotplate arrays, these arrays are more robust, and occupy a relatively small chip area. We present a 2times2 micro-hotplate array as an example, along with its thermal characterisation. In addition we propose arrays connected to each other at wafer level (rather than just within a single chip), that are ideally suited for large volume fabrication of nanomaterial based gas sensors.