gebhart/patrepeval huggingface dataset:
Green function via moment matching for rapid and accurate substrate parasitics evaluation (2002)

Recently the substrate coupling and substrate parasitics are calling for more and more research efforts. This paper addresses this problem by formulating the multilayer substrate Green function equivalent to purely lossy transmission line circuits. Infinite number of exact images can be tracked by wave-tracing. Moment matching technique is used to approximate the fast decaying part while the slow decaying part is extracted by the wave-tracing. We achieve highly accurate yet closed-form space-domain Green function. Parasitics for our MCM on-wafer inductors due to substrate coupling can be efficiently extracted.
[A case control study of lung cancer among workers in dagang oil field, tianjin, china.]. (2009)

Smoking and previous lung disease are the independent risk factors for lung cancer among workers in Dagang oil field, yet due to some potential epidemiological bias, the association between occupational exposure and lung cancer needs further investigation.
Polyelectrolyte Complex of Carboxymethyl Starch and Chitosan as Protein Carrier: Oral Administration of Ovalbumin (2012)

A novel carboxymethyl starch (CMS)/chitosan polyelectrolyte complex (PEC) was proposed as an excipient for oral administration of ovalbumin. The dissolution of ovalbumin from monolithic tablets (200 mg, 2.1 × 9.6 mm, 50% loading) obtained by direct compression was studied. When CMS was used as an excipient, more than 70% of the loaded ovalbumin remained undigested after 1 h of incubation in simulated gastric fluid (SGF) with pepsin. The complete dissolution, after transfer of tablets into simulated intestinal fluid (SIF) with pancreatin, occurred within a total time of about 6 h. Higher protection (more than 90% stability in SGF) and longer dissolution (more than 13 h) were obtained with 50% CMS/50% chitosan physical mixture or with PEC excipients. A lower proportion of chitosan was needed for PEC than for the CMS/chitosan mixture to obtain a similar dissolution profile. The high protection against digestion by pepsin, the various release times and the mucoadhesion properties of these excipients based on CMS favor the development of suitable carriers for oral vaccinations.
Design and experimental characterisationof a linear reciprocating generator (1998)

The paper describes the design and experimental characterisation of a small reciprocating linear permanent-magnet generator which has been developed for on-board generation of electrical power for telemetry vibration monitoring systems. A comprehensive design methodology, which embraces both the electromagnetic and mechanical design, is described. The electromagnetic design synthesis is based around analytical field solutions which allow the optimisation of the generator parameters, and is further verified by nonlinear electromagnetic finite-element analysis. Nonlinear structural finite-element analysis is employed to aid the design of flexural disc springs with the desired stiffness and stroke. The utility of the design methodology is illustrated by a design study and extensive experimental characterisation of a prototype device.
A CMOS bidirectional 32-element phased-array transceiver at 60GHz with LTCC antenna (2012)

An integrated CMOS 60 GHz phased-array antenna module supporting symmetrical 32 TX/RX elements for wireless docking is described. Bidirectional architecture with shared blocks, mm-wave TR switch design with less than 1dB TX loss, and a full built in self test (BIST) circuits with 5deg and +/-1dB measurement accuracy of phase and power are presented. The RFIC size is 29mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , consuming 1.2W/0.85W at TX and RX with a 29dBm EIRP at -19dB EVM and 10dB NF.
Inhibition of Dipeptidyl Peptidase (DPP)-IV and α-Glucosidase Activities by Pepsin-Treated Whey Proteins (2013)

Inhibitors of the enzymes dipeptidyl peptidase (DPP)-IV and α-glucosidase are two classes of pharmacotherapeutic agents used for the treatment of type 2 diabetes. In the present study, whey protein isolate (WPI), α-lactalbumin, β-lactoglobulin, serum albumin, and lactoferrin hydrolysates obtained by peptic digestion were investigated for their potential to serve as natural sources of DPP-IV and α-glucosidase inhibitors. Although inhibition of DPP-IV activity was observed in all pepsin-treated whey proteins studied, the α-lactalbumin hydrolysate showed the greatest potency with an IC50 value of 0.036 mg/mL. Conversely, only WPI, β-lactoglobulin, and α-lactalbumin hydrolysates displayed some inhibitory activity against α-glucosidase. This study suggests that peptides generated from whey proteins may have dual beneficial effects on glycemia regulation and could be used as functional food ingredients for the management of type 2 diabetes.
A New Oxidizing System for Aromatic Alcohols by the Combination of <i>N</i>-Oxoammonium Salt and Electrosynthesized Tetraalkylammonium Tribromide (1991)

Abstract A combination of 2,2,6,6-tetramethyl-1-piperidinyloxyl and tetraalkylammonium tribromides (R4NBr3), which are available from the corresponding tetraalkylammonium bromides via electrooxidation with potassium bromide, has proved to be useful for oxidations of primary and secondary alcohols to the corresponding aldehydes and ketones, respectively. The oxidation reaction proceeds smoothly even with a 0.5–1.0 mol% of N-oxyl compounds and 1.5–2.0 equivalents of tetraalkylammonium tribromides in an aqueous-organic two-phase solution buffered at pH 8.0–8.6. This recyclable oxidant/co-oxidant combination system may involve the formation of N-oxoammonium salts, actual oxidizing agents of alcohols, by the action of hypobromite species generated from R4NBr3 in the binary solution. Utility of the method is highlighted by the selective oxidation of benzylic alcohols bearing electron-releasing groups on the aromatic nucleus to the corresponding aldehydes or ketones without any bromination and overoxidation.
Economic Burden of Transformed Migraine: Results From the American Migraine Prevalence and Prevention (AMPP) Study (2009)

Transformed migraine exacts a significantly higher economic toll on patients and health care systems compared with other forms of migraine. Our findings support the need to prevent migraine progression and to provide appropriate management and treatment of transformed migraine.
The use of melatonin: an information paper. (2000)

The use of melatonin has been a topic of debate for the past several years. Patients frequently ask their physicians about its use, and many physicians are at a loss about what to tell them. Aviators who have trouble sleeping may choose to buy melatonin and use it since it is a "natural" substance. However, they may lack proper education about its use and the issues of concern. Flight surgeons can help educate their patients in the use of melatonin. This paper will briefly discuss the role of melatonin in humans, its effects on circadian rhythms, its sleep-inducing properties, its effects on mood and performance, and issues pertaining to safety. Flight surgeons and other physicians cannot "prescribe" melatonin, but they at least can offer information about its effects and what is not known about melatonin at this time to the aviators who may ask questions concerning this product.
Congestive Heart Failure Risk in Patients With Breast Cancer Treated With Bevacizumab (2011)

This is the first comprehensive report to show that bevacizumab is associated with an increased risk of significant heart failure in patients with breast cancer.
A Late Devonian Reef Tract on Northeastern Banks Island, N.W.T. (1971)

ABSTRACT The Upper Devonian Weatherall Formation, outcropping on northeastern Banks Island, N.W.T., contains a 200-ft-thick limestone unit here termed the Mercy Bay Member. The member is Middle to Late Frasnian in age. Gyrfalcon Bluff has been chosen as the type section. Mercy Bay Member outcrops on the extreme northeastern portion of Banks Island, and many excellent exposures permit detailed paleogeographical and paleoecological studies. The member contains numerous organic build-ups and represents a Late Devonian reef tract located in the marine-shelf environment of an exogeosyncline situated between a tectonic highland to the northwest and a stable craton to the southeast. The main facies changes in the Mercy Bay Member occur in an east-west direction. The organic build-ups in the eastern part of the study area are narrow, linear bioherms trending north-south. They are encased in younger terrigenous clastic rocks. To the west the organic build-ups, which are biohermal in the lower part and biostromal in the upper, are more numerous. The lower bioherms trend east-west. Penecontemporaneous interbiohermal strata consist of dark, fine-grained argillaceous limestone. Organic build-ups on the western edge of the outcrop area are bioherms which trend north-south. The lower portion in all organic build-ups consists of corals and tabular stromatoporoids. These are interpreted as biogenetic banks constructed in the quiet and intermediate-energy zones (water depths more than 30 ft). The upper portion is composed of massive stromatoporoids. This facies represents rigid reefs constructed in the high-energy zone (above 30 feet). Successive sea-level rises allowed the reefs to grow upward. Cessation of reef growth was caused by an influx of terrigenous sediment related to the seaward migration of the northern and western shorelines. The outcropping organic build-ups of the Mercy Bay Member are tightly cemented, but frequent bitumen occurrences indicate that they were once oilbearing. Organic build-ups of the Mercy Bay Member probably occur in the subsurface to the west. End_Page 730------------------------
Widely Tunable Dual-loop Optoelectronic Oscillator (2014)

We demonstrate a record widely tunable dual-loop optoelectronic oscillator with tunable band from 3.39 to 57.50 GHz. The single-side band phase noise is below −120 dBc/Hz at 10 kHz offset for all the measurement frequency points.
Molecular determinants of the platelet aggregation inhibitory activity of carbamoylpiperidines (1992)

A series of alpha,alpha'-bis[3-(N,N-dialkylcarbamoyl)piperidino]-p- xylenes were synthesized and tested for their inhibitory activity on ADP-induced aggregation of human platelets. A parabolic curve was obtained when log 1/C (activity) was plotted against log P (octanol/water partition coefficient). Using this as a model, a new analogue, alpha,alpha'-bis-[3-(N-methyl-N-butylcarbamoyl)piperidino]-p-xylen e (3g), was synthesized with a predicted IC50 of 25 microM. When this compound was subsequently evaluated, the IC50 was 22.1 +/- 5.5 microM, demonstrating the applicability of this model. The amide oxygen of the carbamoyl substituent appeared necessary for activity. Thus, for example, when the amide carbonyl group of 3a (IC50 = 44.5 microM) was reduced to CH2, the resulting compound 4 had a dramatically reduced activity, IC50 = 1565 microM. Compound 3a was resolved into (+) and (-) enantiomers and a meso (0) diastereomer using fractional crystallization, diastereomeric tartrate formation, and chiral HPLC. Compared to (-)-3a, the (+) isomer was 15 times more potent when ADP was the agonist and 19 times more active when collagen was used as the agonist. Molecular modeling of R,R- and S,S-3a using the SYBYL program was used to examine their interactions with phosphatidylinositol (PI). There was a better fit between PI and the R,R-3a with the energy of interaction being 17.6 kcal/mol less than that of the S,S-3a/PI complex. Although the absolute stereochemistry of individual enantiomers is not known, this study shows that R,R-3a interacts more favorably with PI than does S,S-3a and that (+)-3a is a more potent inhibitor of human platelet aggregation than (-)-3a. It is postulated that because of their lipophilicity, these compounds penetrate the platelet membrane and are then protonated at the pH of the cytosol. The protonated N then neutralizes the anionic charge on the membrane phosphoinositides, thereby rendering them less susceptible to hydrolysis by phospholipase C. Thus, the determinant parameters for optimum antiplatelet activity in 3-carbamoylpiperidines are (1) the amide carbonyl, (2) appropriate stereochemistry of the 3-substituent and (3) a log P value of about 4.5.
Nonterminal differentiation represses the neoplastic phenotype in spontaneously and simian virus 40-transformed cells. (1989)

The potential of nonterminal cellular differentiation to stably repress the expression of the neoplastic phenotype of transformed cells is established. Nonterminal differentiation induces spontaneously transformed 3T3 T cells to revert to a nontransformed state and induces the revertant cell clones to become resistant to retransformation by UV irradiation or 4-nitroquinoline oxide treatment. Nonterminal differentiation also induces simian virus 40-transformed 3T3 T cells to repress expression of the large tumor antigen and to revert to a nontransformed state. Although the molecular mechanisms that mediate these and other forms of anticancer activity have not been definitively established, data are presented which suggest that differentiation-induced repression of large tumor antigen expression can be regulated at the level of transcription and/or RNA processing.
Data Driven and AI Methods to Enhance Collaborative Well Planning and Drilling Risk Prediction (2020)

Abstract ADNOC is continuously enhancing its capabilities to manage its oil and fields efficiently by better planning, execution and operations that drives field development decisions, well performance, and safe operations. In this regard, ADNOC envisages to leverage the evolving Oil and Gas 4.0 technologies to enhance the well planning decisions of the sub-surface and drilling team through data-driven and AI methods. Effective well planning and operations require collaboration between different subsurface teams and drilling team leveraging multidisciplinary data, historical events and risks and constructing integrated drilling and sub-surface model for collaborative planning and keeping the model live. This requires having a live sub-surface model that is kept close to the field reality while reducing uncertainties. However, extracting key learnings, knowledge and experience from a variety of sources and reports is intense and requires lot of manual processing of data. An AI-based solution leveraging data analytics, natural language processing and machine learning algorithms is developed to automatically extract knowledge from a variety of data sources and unstructured data in building a live intelligent model that enables effective well planning, predicting operational hazards and plan mitigation. The solution systematically extracts, collects, validates, integrates, and processes a variety of data in different formats such as well trajectory, completion, historical events, risk offset well information, petrophysical data, geo-mechanical data, and technical reports. Newly acquired data comprising drilling events, geological and reservoir properties are integrated continuously to keep the model live and digital representation.
Unilateral Lesions of the Cholinergic Basal Forebrain and Fornix in One Hemisphere and Inferior Temporal Cortex in the Opposite Hemisphere Produce Severe Learning Impairments in Rhesus Monkeys (2002)

It has been proposed that isolation of the inferior temporal cortex and medial temporal lobe from their cholinergic afferents results in a severe anterograde amnesia. To test this hypothesis directly, seven rhesus monkeys received a unilateral immunotoxic lesion of the cholinergic cells of the basal forebrain with an ipsilesional section of the fornix. In a second surgery, inferior temporal cortex was ablated in the opposite hemisphere. All animals were severely impaired at learning visual scenes and object-reward associations. The impairment in learning scenes was correlated with cholinergic cell loss in the basal forebrain, but not with generalized tissue damage. Two monkeys served as surgical controls with saline injection in place of the immunotoxin, but all other procedures the same, and were not as severely impaired as those with immunotoxic lesions. Previous work has shown that monkeys with bilateral section of the anterior temporal stem (white matter of the temporal lobe), amygdala and fornix show a severe new learning impairment, and provide a model of human medial temporal lobe amnesia. One effect of this combined ablation is to isolate inferior temporal cortex and medial temporal lobe from their cholinergic afferents, possibly in addition to a direct disruption of the hippocampal system. The results of the present study, then, provide a novel link between the mechanisms of medial temporal lobe amnesia and Alzheimer's disease in which the cholinergic basal forebrain shows pathology. We propose that in both cases the mnemonic impairments result from isolating inferior temporal cortex and medial temporal lobe from their cholinergic afferents, possibly in addition to a direct disruption of the hippocampal system.
Increase of Eicosapentaenoic Acid in Thraustochytrids through Thraustochytrid Ubiquitin Promoter-Driven Expression of a Fatty Acid Δ5 Desaturase Gene (2011)

Thraustochytrids, marine protists known to accumulate polyunsaturated fatty acids (PUFAs) in lipid droplets, are considered an alternative to fish oils as a source of PUFAs. The major fatty acids produced in thraustochytrids are palmitic acid (C(16:0)), n - 6 docosapentaenoic acid (DPA) (C(22:5)(n) (- 6)), and docosahexaenoic acid (DHA) (C(22:6)(n) (- 3)), with eicosapentaenoic acid (EPA) (C(20:5)(n) (- 3)) and arachidonic acid (AA) (C(20:4)(n) (- 6)) as minor constituents. We attempted here to alter the fatty acid composition of thraustochytrids through the expression of a fatty acid Δ5 desaturase gene driven by the thraustochytrid ubiquitin promoter. The gene was functionally expressed in Aurantiochytrium limacinum mh0186, increasing the amount of EPA converted from eicosatetraenoic acid (ETA) (C(20:4)(n) (- 3)) by the Δ5 desaturase. The levels of EPA and AA were also increased by 4.6- and 13.2-fold in the transgenic thraustochytrids compared to levels in the mock transfectants when ETA and dihomo-γ-linolenic acid (DGLA) (C(20:3)(n) (- 6)) were added to the culture at 0.1 mM. Interestingly, the amount of EPA in the transgenic thraustochytrids increased in proportion to the amount of ETA added to the culture up to 0.4 mM. The rates of conversion and accumulation of EPA were much higher in the thraustochytrids than in baker's yeasts when the desaturase gene was expressed with the respective promoters. This report describes for the first time the finding that an increase of EPA could be accomplished by introducing the Δ5 desaturase gene into thraustochytrids and indicates that molecular breeding of thraustochytrids is a promising strategy for generating beneficial PUFAs.
Azo Compounds.<sup>1</sup> A Re-examination of the Structure of the Product from the Reaction of Heptane-2,6-dione with Hydrazine Sulfate and Sodium Cyanide in Dilute Solution (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzo Compounds.1 A Re-examination of the Structure of the Product from the Reaction of Heptane-2,6-dione with Hydrazine Sulfate and Sodium Cyanide in Dilute SolutionC. G. Overberger and Burton S. MarksCite this: J. Am. Chem. Soc. 1955, 77, 15, 4097–4100Publication Date (Print):August 1, 1955Publication History Published online1 May 2002Published inissue 1 August 1955https://pubs.acs.org/doi/10.1021/ja01620a039https://doi.org/10.1021/ja01620a039research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiplexed, High-Throughput Genotyping by Single-Base Extension and End-Labeled Free-Solution Electrophoresis (2002)

Technologies that allow for high-throughput, economical, and accurate single nucleotide polymorphism (SNP) genotyping are becoming crucial for modern genomic efforts. Here, we present a method for multiplexed single-base extension (SBE) genotyping that takes advantage of the unique separation modalities made possible via end-labeled free-solution electrophoresis (ELFSE). Three unique SBE oligonucleotide primers, which probe for mutations of clinical importance in the human p53 gene, were covalently conjugated to three unique polypeptoid frictional end labels and mixed together. This primer-polypeptoid conjugate cocktail was then used in a multiplexed SBE reaction followed by free-solution separation in a 96-capillary array electrophoresis (CAE) instrument. The study was designed to demonstrate multiplexed SNP genotyping of several loci in a single reaction and a single subsequent analysis. Further, the electrophoretic analysis was conducted without any viscous polymeric separation media, was complete in less than 10 min, and can be implemented in any capillary or microfluidic electrophoretic system with four-color fluorescent detection capabilities. Multiplexed SBE-ELFSE genotyping analysis resulted in the simultaneous and accurate genotyping of three p53 loci on five different DNA templates in a single reaction set and single CAE analysis. With the implementation of this method in 96 or more capillaries in parallel, high-throughput screening of SNPs will be accessible to a large number of laboratories.
Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx (2013)

Reactive oxygen species (ROS) play a key role in the pathogenesis of proteinuria in glomerular diseases like diabetic nephropathy. Glomerular endothelial cell (GEnC) glycocalyx covers the luminal aspect of the glomerular capillary wall and makes an important contribution to the glomerular barrier. ROS are known to depolymerise glycosaminoglycan (GAG) chains of proteoglycans, which are crucial for the barrier function of GEnC glycocalyx. The aim of this study is to investigate the direct effects of ROS on the structure and function of GEnC glycocalyx using conditionally immortalised human GEnC. ROS were generated by exogenous hydrogen peroxide. Biosynthesis and cleavage of GAG chains was analyzed by radiolabelling (S(35) and (3)H-glucosamine). GAG chains were quantified on GEnC surface and in the cell supernatant using liquid chromatography and immunofluorescence techniques. Barrier properties were estimated by measuring trans-endothelial passage of albumin. ROS caused a significant loss of WGA lectin and heparan sulphate staining from the surface of GEnC. This lead to an increase in trans-endothelial albumin passage. The latter could be inhibited by catalase and superoxide dismutase. The effect of ROS on GEnC was not mediated via the GAG biosynthetic pathway. Quantification of radiolabelled GAG fractions in the supernatant confirmed that ROS directly caused shedding of HS GAG. This finding is clinically relevant and suggests a mechanism by which ROS may cause proteinuria in clinical conditions associated with high oxidative stress.