gebhart/patrepeval huggingface dataset:
Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinoma (2014)

Overexpression of FOXM1 is associated with metastases of NPC patients. Thiostrepton inhibits the metastatic ability of NPC cells by down-regulating the expression of FOXM1, MMP-2, MMP-9, fascin-1, and paxillin.
Magnetically Suspended Centrifugal Blood Pump with an Axially Levitated Motor (2003)

The longevity of a rotary blood pump is mainly determined by the durability of its wearing mechanical parts such as bearings and seals. Magnetic suspension techniques can be used to eliminate these mechanical parts altogether. This article describes a magnetically suspended centrifugal blood pump using an axially levitated motor. The motor comprises an upper stator, a bottom stator, and a levitated rotor-impeller between the stators. The upper stator has permanent magnets to generate an attractive axial bias force on the rotor and electric magnets to control the inclination of the rotor. The bottom stator has electric magnets to generate attractive forces and rotating torque to control the axial displacement and rotation of the rotor. The radial displacement of the rotor is restricted by passive stability. A shrouded impeller is integrated within the rotor. The performance of the magnetic suspension and pump were evaluated in a closed mock loop circuit filled with water. The maximum amplitude of the rotor displacement in the axial direction was only 0.06 mm. The maximum possible rotational speed during levitation was 1,600 rpm. The maximum pressure head and flow rate were 120 mm Hg and 7 L/min, respectively. The pump shows promise as a ventricular assist device.
2-D Evidential Grid Mapping with Narrow Vertical Field of View Sensors Using Multiple Hypotheses and Spatial Neighborhoods (2015)

Environment sensors with a narrow vertical field of view often fail to detect obstacles with a small vertical extent from close range. Because an inverse beam sensor model infers free space when there was no measurement, those obstacles are deleted from an occupancy grid eventhough they have been observed in past measurements. This is extremely critical if the car is driving autonomously. Our approach explicitly models these errors using multiple hypotheses in an evidential grid mapping framework that neither needs a classification nor a height of obstacles. Furthermore, we extend the grid mapping framework, that usually assumes mutually independent cells, by including information from neighboring cells. The evaluation in a freeway and a challenging scenario with a boom barrier shows that our method is superior to evidential grid mapping with an inverse beam sensor model.
Magnetic, transport and structural properties of Co/Ir multilayers grown by molecular beam epitaxy (2003)

We report on the structural properties of a [Co30/Ir10]10× (Å) superlattice, as well as on the magnetic and transport properties of a Co15/Ir5/Co30 (Å) artificial ferrimagnetic system. The samples were grown by molecular beam epitaxy (MBE) on MgO(001) substrates covered with a Ir130 (Å) buffer layer. High resolution cross section and plan view transmission electron microscopy (TEM) images present a high quality epitaxial stack [100]MgO(001) ‖ [100]Ir(001) ‖ [100]Co(001), with a tetragonalization of the Co fcc structure, due to strains induced by the Ir buffer. TEM images also show that the Co/Ir interfaces are flat, while the layers are continuous and free of bridges. These observations are consistent with zero field nuclear magnetic resonance measurements which indicate an fcc structure of the Co layers, and an interface mixing between Co and Ir limited to one atomic layer. As a consequence the antiferromagnetically coupled Co/Ir/Co sandwich presents large saturation and coercive fields which exceed 20 kOe and 220 Oe, respectively. Annealing made on the same sandwich indicate that the magnetic and transport properties are stable up to 300 °C. (© 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers (2005)

The results suggest that caffeine administered in the gum formulation (Stay Alert chewing gum) via a multiple dosing regimen provides an effective and convenient means of maintaining effective concentrations of caffeine that would in some operational scenarios be desirable for maintaining alertness and performance in sleep deprived individuals.
Infection and Pathogenicity of Chimeric Simian‐Human Immunodeficiency Viruses in Macaques: Determinants of High Virus Loads and CD4 Cell Killing (1997)

Chimeric simian-human immunodeficiency viruses (SHIVs) carrying envelope glycoproteins derived from a T cell-macrophage dual-tropic primary isolate (human immunodeficiency virus type 1 [HIV-1] strain DH12) were constructed. When inoculated into macaque monkeys, SHIV(MD14) carrying simian immunodeficiency virus-derived nef established significantly higher virus loads than did SHIV(MD1), which contains the HIV-1 nef gene. Three patterns of CD4 cell depletion were observed in infected monkeys: exponential and irreversible loss to undetectable levels within 10 weeks of infection; marked reduction during acute infection followed by partial recovery and stabilization (lasting from 10 weeks to > 1 year), with a later decline to undetectable levels in some animals; and a transient loss during acute infection. The induced immunodeficiency was accompanied by CD4 cell counts of < 50 cells/microL and was associated with Pneumocystis carinii pneumonia, cytomegalovirus meningoencephalitis, lymphoid depletion, and thymic atrophy.
Performance of Bridge Deck Link Slabs Designed with Ductile Engineered Cementitious Composite (2004)

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Advanced two-step transcriptional amplification as a novel method for cancer-specific gene expression and imaging (2011)

The two-step transcriptional amplification (TSTA) system was previously reported to enhance the tissue-specific gene expression driven by weak promoters, but the enhancement of the gene expression is limited to use in in vitro and in vivo experimental situations. To achieve robust tissue-specific gene expression using the TSTA system, we developed an advanced TSTA system which includes polyglutamines and rat glucocorticoid receptor sequences between the GAL4 and VP16 sequences in the region of the first step of transcription. We evaluated the advanced TSTA system as a method to enhance the human telomerase reverse transcriptase (hTERT) promoter-driving cancer-specific transcription in various cancer cell lines. As a result, the advanced TSTA enhanced cancer-specific luciferase gene expression in all of the examined cancer cell lines, when compared with both the one-step and conventional TSTA systems (an ~6- and ~17-fold enhancement, respectively). Notably, the enhancement of the hTERT driven expression by the conventional TSTA system was modest and even inferior to the one-step system in several cancer cell lines. We then constructed a luciferase gene encoding the adeno-associated virus vector in which the hTERT promoter-mediated expression was driven by the advanced TSTA or control systems. In an orthotopic liver tumor model, mice were treated with the vector via tail vein injection. An optical imaging device was used to visualize the in vivo luciferase expression in the orthotopic tumor. The advanced TSTA system significantly enhanced the luciferase expression compared with the one-step and conventional TSTA systems (18.0±1.0- and 15.9±0.85-fold gain, respectively). Therefore, the advanced TSTA system significantly improves hTERT-dependent cancer-specific gene expression both in vitro and in vivo when compared with the previous systems. Since the advanced TSTA method can also be applied to other site-specific gene expression systems using tissue-specific promoters, this approach is expected to become a valuable tool enabling in vivo site-specific targeting in the field of gene therapy and molecular imaging.
Eye Tracking and Web Experience (2014)

User experience research aims to understand a user’s point of view. Because eye tracking allows us to literally see through a user’s eyes, it can serve as a valuable tool in web studies, particularly in web design and development. To understand how eye tracking can be pivotal in website studies, this paper scientifically explains how the human visual system works and how eye tracker technologies can record what we register with our eyes. It then explains how web design can benefit from the data that eye tracking studies deliver. Finally, the paper discusses trends for eye tracking in future web experience research.
Single-Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3′-Diindolylmethane in Healthy Subjects (2008)

We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. Groups of four subjects were enrolled for each dose level. After randomization, one subject in each group received placebo whereas three received active BR-DIM. The doses administered were 50, 100, 150, 200, and 300 mg, with the 300-mg dose repeated in an additional group. No BR-DIM-related adverse effects were reported at doses up to 200 mg. At the 300-mg dose, one of six subjects reported mild nausea and headache and one also reported vomiting. Only the latter effect was judged as probably related to the study agent. Analysis of serial plasma samples showed that only one subject at the 50-mg dose had detectable concentrations of DIM. The single 100-mg dose of BR-DIM resulted in a mean maximum plasma concentration (C(max)) of 32 ng/mL and a mean area under the curve (AUC) of 128 h ng/mL, and a single 200-mg dose produced a mean C(max) of 104 ng/mL and a mean AUC of 553 h ng/mL. The single 300-mg dose of BR-DIM resulted in a mean C(max) of 108 ng/mL and a mean AUC of 532 h ng/mL. We conclude that BR-DIM is well tolerated at single doses of up to 200 mg, and that increasing the dose to 300 mg did not result in an increase in C(max).
Use of dehydrated human amniotic membrane allografts to promote healing in patients with refractory non healing wounds (2013)

Non healing wounds present a significant social and economic burden. Chronic non healing wounds are estimated to affect as many as 1-2% of individuals during their lifetime, and account for billions of dollars of expense annually on both a national and global basis. Our purpose is to describe the use of a novel dehydrated amniotic membrane allograft (EpiFix(®) ; MiMedx Group, Inc., Kennesaw, GA) for the treatment of chronic non healing wounds. We describe the results of EpiFix treatment in four patients who had not achieved wound closure with both conservative and advanced measures, and had been referred for a definitive plastic surgery procedure. Healing was observed in a variety of wounds with one to three applications of the dehydrated amniotic membrane material. The material was well tolerated by patients. Healed wounds did not recur in long-term follow-up. Further investigation of the use of dehydrated amniotic membrane in broader application to various types of dermal wounds should be considered.
E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. (1996)

Rb protein is a critical regulator of entry into the cell cycle, and loss of Rb function by deletions, mutations, or interaction with DNA viral oncoproteins leads to oncogenic transformation. We have shown that the human papilloma virus (HPV)-16 E7 gene is sufficient to induce the immortalization of mammary epithelial cells (MECs). Surprisingly, the steady-state level of Rb protein in these immortal cells was drastically decreased. Here, we used pulse-chase analysis to show that the in vivo loss of Rb protein in E7-immortalized MECs is a consequence of enhanced degradation. Expression of HPV16 E7 in a cell line with a temperature-sensitive mutation in the E1 enzyme of the ubiquitin pathway demonstrated that degradation of Rb was ubiquitin dependent. Treatment of E7-immortalized MECs with aldehyde inhibitors of proteasome-associated proteases led to a marked stabilization of Rb protein, particularly the hypophosphorylated form. Taken together, our results provide evidence for HPV-16 E7-induced enhanced degradation of Rb protein via a ubiquitin-proteasome pathway and suggest a second mechanism of oncogenic transformation by E7, in addition to its previously identified ability to sequester Rb from E2F. Our analyses also show that normal Rb levels are regulated by the ubiquitin-proteasome degradation pathway.
Reconfigurable lattice mesh designs for programmable photonic processors (2016)

We propose and analyse two novel mesh design geometries for the implementation of tunable optical cores in programmable photonic processors. These geometries are the hexagonal and the triangular lattice. They are compared here to a previously proposed square mesh topology in terms of a series of figures of merit that account for metrics that are relevant to on-chip integration of the mesh. We find that that the hexagonal mesh is the most suitable option of the three considered for the implementation of the reconfigurable optical core in the programmable processor.
Glycosyl-Phosphatidylinositol Moiety That Anchors <i>Trypanosoma brucei</i> Variant Surface Glycoprotein to the Membrane (1988)

Two forms of protein-membrane anchor have been described for the externally disposed glycoproteins of eukaryotic plasma membranes; namely, the hydrophobic transmembrane polypeptide and the complex glycosylphosphatidylinositol (G-PI) moiety. The chemical structures of the major species of G-PI anchors found on a single variant surface glycoprotein (VSG) of the parasitic protozoan Trypanosoma brucei were determined by a combination of nuclear magnetic resonance spectroscopy, mass spectrometry, chemical modification, and exoglycosidase digestions. The G-PI anchor was found to be heterogeneous with respect to monosaccharide sequence, and several novel glycosidic linkages were present. The results are pertinent to the mechanism of the biosynthesis of G-PI anchors.
Galaxy Clustering and Large-Scale Structure from z = 0.2 to z = 0.5 in Two Norris Redshift Surveys (1999)

(abridged) We present a study of the nature and evolution of large-scale structure based on two independent redshift surveys of faint field galaxies conducted with the 176-fiber Norris Spectrograph on the Palomar 200-inch telescope. The two surveys together sparsely cover ~20 sq. degrees and contain 835 r < 21 mag galaxies with redshifts 0.2 < z < 0.5. Both surveys have a median redshift of z = 0.30. In order to obtain a rough estimate of the cosmic variance, we analyze the two surveys independently. We measure the comoving correlation length to be 3.70 +/- 0.13 h^-1 Mpc at z = 0.30 with a power-law slope gamma = 1.77 +/- 0.05. Dividing the sample into low (0.2 < z < 0.3) and high (0.32 < z < 0.5) redshift intervals, we see no evidence for a change in the comoving correlation length over the redshift range 0.2 < z < 0.5. Similar to the well-established results in the local universe, we find that intrinsically bright galaxies are more strongly clustered than intrinsically faint galaxies and that galaxies with little ongoing star formation, as judged from the rest-frame equivalent width of the [OII]3727, are more strongly clustered than galaxies with significant ongoing star formation. The rest-frame pairwise velocity dispersion of the sample is 326^+67_-52 km s^-1, ~25% lower than typical values measured locally. The appearance of the galaxy distribution, particularly in the more densely sampled Abell 104 field, is quite striking. The pattern of sheets and voids which has been observed locally continues at least to z ~ 0.5. A friends-of-friends analysis of the galaxy distribution supports the visual impression that > 90% of all galaxies at z < 0.5 are part of larger structures with overdensities of > 5.
Synthesis of aza macrocycles by nucleophilic ring closure with cesium tosylamides (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of aza macrocycles by nucleophilic ring closure with cesium tosylamidesBindert K. Vriesema, Jan Buter, and Richard M. KelloggCite this: J. Org. Chem. 1984, 49, 1, 110–113Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jo00175a022https://doi.org/10.1021/jo00175a022research-articleACS PublicationsRequest reuse permissionsArticle Views686Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Current Expectations for Cardiac Transplantation in Patients With Congenital Heart Disease (2016)

Congenital heart disease accounts for 40% of pediatric heart transplants and presents unique challenges to the transplant team. Suitability for transplantation is defined in part by degree of sensitization, pulmonary vascular resistance, and hepatic reserves. The incremental transplant risk for patients with congenital heart disease occurs within the first 3 months, after which survival is equivalent to transplantation for cardiomyopathy. Single ventricle with prior palliation, and especially the failing Fontan, carry the highest risk for transplantation and are least amenable to bridging with mechanical circulatory support. More effective bridging to transplant with mechanical circulatory support will require improvements in the adverse event profile of available pumps and the introduction of miniaturized continuous flow technology. The major barriers to routine long-term survival are chronic allograft failure and allograft vasculopathy. Despite these many challenges, continuing improvements in the care of pediatric heart transplant patients have pushed the median posttransplant survival past 15 years for children and to 20 years for infants.
호텔종사자의 직무요구와 직무자원(JD-R), 직무열의, 자아효능감 및 업무성과간의 관계연구 (2013)

The aims of this research were to identify critical factors of not only job demands but also job resources in inducing hotel employees` work engagement and examine the interrelationship among work engagement, self efficacy and department performance. Based on the literature review, proposed model and 10 hypotheses were derived. The conceptual model empirically tested using data collected from 319 hotel employees. The results from structural equation modeling reveled that (1) two sub-dimensions of job demands, which include work overload and emotional demands, have negative impact on work engagement, but the other one, work-home interference, does not have a significant impact on work engagement, (2) among four sub-dimensions of job resources, three sub-dimensions (social support, job autonomy and opportunities to learn and to develop) enhance work engagement but feedback, and (3) work engagement positively influences on both self-efficacy and department performance. In addition, the effect of self-efficacy on department performance is significant. Based on the findings from this empirical study, theoretical and practical implications are discussed.
CFD Simulations of Gas and Liquid Slugs for Taylor Flow in a Microchannel (2005)

The rapid development of microfabrication techniques creates new opportunities for applications of microchannel reactor technology in chemical reaction engineering. The extremely large volume-to-surface ratio and the short transport path in microchannels enhance heat and mass transfer dramatically and hence provide many potential opportunities in chemical process development and intensification. Multiphase reactions involving gas/liquid reactants with a solid as a catalyst are ubiquitous in the chemical and pharmaceutical industries, and the hydrodynamics play a prominent role in reactor design and performance. For gas/liquid two-phase flow in a microchannel, the Taylor slug flow regime is the most commonly encountered flow pattern, therefore the present study deals with the numerical simulation of gas and liquid slugs in a microchannel. A T-junction microchannel (empty or packed) with varying cross-sectional width (0.25, 0.5, 0.75, 1, 2 and 3 mm) served as the model micro-reactor, and a finite volume based commercial CFD package, FLUENT, was adopted for the numerical simulation. The gas and liquid slug lengths at various operating conditions were obtained and found to be in good agreement with the literature data.© 2005 ASME
Characterization and genetic restriction of suppressor-effector cells induced by staphylococcal enterotoxin B. (1990)

The capacity of the staphylococcal enterotoxins to stimulate all T cells bearing certain (but not all) TCR has generated a great deal of interest. This stimulation appears to involve specific binding of the toxin to class II Ags and subsequent stimulation via the TCR. Previous studies from this laboratory have demonstrated that staphylococcal enterotoxin B (SEB) induces multiple T suppressor cell populations that inhibit both primary and secondary plaque-forming cell responses. Efforts to characterize these suppressor cell populations have demonstrated that the suppressor population active early in the antibody response expresses the Lyt-1-2+ cell surface phenotype, whereas depletion analysis suggests that the population active late in an ongoing response bears the Lyt-1+2+ cell-surface markers. In the present study, enrichment for this late acting effector population with the use of sequential panning with anti-Lyt mAb reveals significant suppressive activity at both the initiation and effector phases of a 5-day Mishell-Dutton coculture. Additional experiments using I-J disparate strains of mice have demonstrated a genetic restriction at the "I-J" gene locus between the cells mediating SEB-induced suppression and their target. Depletion of SEB-primed splenocytes with anti-I-J mAb suggests that both the early and late effector cells bear I-J molecules on their surface. Taken together, these results show that SEB induces suppressor cell populations with properties similar to those exhibited by Ag-specific cell circuits.