gebhart/patrepeval huggingface dataset:
Determinants of Bargaining Outcomes in the Federal Government of Canada (1979)

Examination of the impact of characteristics of bargaining determinants on a bargaining outcome in a sample of units negotiating with the Canadian federal government. Role of characteristics of the economic, legal, and political environment in the wage determination process; Methods used in the study; Results. (Abstract copyright EBSCO.)
Ginseng modulates the immune response by induction of interleukin‐12 production (2004)

In infections with intracellular microorganisms such as mycobacteria and Leishmania parasites as well as certain extracellular chronic infections such as Pseudomonas aeruginosa a Th1 response with activation of macrophages is desirable. Several studies indicate that such a response is associated with better recovery from infection, improved course of the chronic infection, and higher survival rate. In Th1 responses there is increased interferon-gamma (IFN-gamma) and interleukin-12 (IL-12) production, whereas that of interleukin-10 (IL-10) is decreased. The present study indicated that Ginseng modulation of stimulated peripheral blood mononuclear cells (PBMC) results in a higher IL-12 production. The enhanced IL-12 production could induce a stronger Th1 response, resulting in better protection against infection with a variety of pathogens.
Active Stabilization for Robotized Beating Heart Surgery (2011)

In this paper, control strategies for an active stabilizer dedicated to beating heart coronary artery bypass grafting are investigated. The active stabilizer, which consists of a piezoactuated compliant mechanism, has to be controlled to compensate for the displacements induced by the beating heart in order to provide the surgeon with a locally motionless myocardium surface. Three controllers, including different levels of prior knowledge about the heart motion, are presented. Their performance with respect to modeling uncertainties, arising unknown interactions of the stabilizer with its positioning mechanism, and the heart, is studied through simulations, as well as laboratory and in vivo experiments. Finally, the selection of the most adequate control scheme and the performance of the device from a clinical point of view are discussed.
High temperature performance of NMOS integrated inverters and ring oscillators in 6H-SiC (2000)

Electrical characterization up to 573 K is performed on integrated inverters with different beta ratios and 17-stage ring oscillators based on SiC NMOS technology. These devices are fabricated on a p-type 6H-SiC epitaxial layer with a doping concentration of N/sub A/=1/spl middot/10/sup 16/ cm/sup -3/. The n/sup +/ source/drain regions and buried channels for depletion-mode load transistors are achieved by ion implantation of nitrogen. Direct current measurements of the inverters with a 5 V power supply yield proper output levels and acceptable noise margins both at 303 and 573 K. Dynamic measurements with square waves show the full voltage swing up to 5 kHz in this temperature range. The 17-stage ring oscillators, driven by a 5.5 V power supply, show an oscillator frequency of 625 kHz at 303 K, which corresponds to a 47 ns delay per inverter stage. This time constant increases only to 59 ns at 573 K. The temperature drift of the measured output signal is well below 30% up to this elevated temperatures. During 20 heat cycles up to 573 K in air, no measurable drift in circuit parameters occurred. In addition, only a slight dependence of the oscillator frequency on supply voltage is observed.
TIERS: Topology IndependEnt Pipelined Routing and Scheduling for VirtualWire &#8482; Compilation (1995)

TIERS is a new pipelined routing and scheduling algorithm implemented in a completeVirtualWire TM compilation and synthesis system. TIERS is described and compared to prior work both analytically and quantitatively. TIERS improves system speed by as much as a factor of 2.5 over prior work. TIERS routing results for both Altera and Xilinx based FPGA systems are provided.
Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis (2014)

The present study suggests that altered monoamine turnover rates in CNS reflect intermediate steps in the associations between SNPs and psychosis.
Comparison of structure, function and regulation of plant cold shock domain proteins to bacterial and animal cold shock domain proteins (2010)

The cold shock domain (CSD) is among the most ancient and well conserved nucleic acid binding domains from bacteria to higher animals and plants. The CSD facilitates binding to RNA, ssDNA and dsDNA and most functions attributed to cold shock domain proteins are mediated by this nucleic acid binding activity. In prokaryotes, cold shock domain proteins only contain a single CSD and are termed cold shock proteins (Csps). In animal model systems, various auxiliary domains are present in addition to the CSD and are commonly named Y-box proteins. Similar to animal CSPs, plant CSPs contain auxiliary C-terminal domains in addition to their N-terminal CSD. Cold shock domain proteins have been shown to play important roles in development and stress adaptation in wide variety of organisms. In this review, the structure, function and regulation of plant CSPs are compared and contrasted to the characteristics of bacterial and animal CSPs. [BMB reports 2010; 43(1): 1-8].
Mulitmodal interaction for distributed interactive simulation (1997)

Nearly three quarters of our cohort (n=17) presented with classic virilising form of 21-hydroxylase deficiency. Only four (25%) patients experienced a salt-losing crisis. Female gender assignment at birth was maintained for all individuals in this group. 'Good' and 'satisfactory' outcomes of surgery were reported in nearly all participants.
The preparation and crystal structures of new platinum/phosphonate complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe preparation and crystal structures of new platinum/phosphonate complexesRobert. Bau, Sharon K. S. Huang, Jin An. Feng, and Charles E. McKennaCite this: J. Am. Chem. Soc. 1988, 110, 22, 7546–7547Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://doi.org/10.1021/ja00230a050RIGHTS & PERMISSIONSArticle Views195Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Measurements of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow/><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msup></mml:mrow><mml:mi mathvariant="normal">He</mml:mi></mml:math>spin-exchange rates (2002)

Spin-exchange rate coefficients for Rb-${}^{3}\mathrm{He}$ are measured using three different methods. Two methods, using Rb repolarization and rate balance, require no assumption about the nature of the ${}^{3}\mathrm{He}$ wall relaxation and agree well; we find spin-exchange rate coefficients of $6.7\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}20}{\mathrm{cm}}^{3}/\mathrm{s}$ and $6.8\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}20}{\mathrm{cm}}^{3}/\mathrm{s}.$ These results agree with a recent repolarization measurement of Baranga and co-workers [Phys. Rev. Lett. 80, 2801 (1998)]. The third method uses the temperature dependence of the ${}^{3}\mathrm{He}$ relaxation and is 30% larger than the other two, implying a temperature-dependent wall or an unreasonably large value of the anisotropic spin-exchange interaction for $\mathrm{Rb}{\ensuremath{-}}^{3}\mathrm{He}.$ In the course of these measurements we developed and tested a new method for Rb density measurements under high power pumping conditions, and a new variant of Rb EPR polarimetry, both of which are described here.
Front crash simulation and design improvement of a pure electric vehicle (2011)

A finite element model is built for a pure electric vehicle (PEV) with battery mounted in the engine compartment. Front crash simulation is conducted using the built model with LS-DYNA according to FMVSS 305. The simulation result shows that battery acceleration and intrusion into the passenger cabin are so excessive that initial design needs to be improved. Hot forming steel is then applied to the longitudinal beam's extension part to prevent its crush defromation. Simulation result with the new design shows that the extension part's deformation is improved significantly. As a result, battery acceleration is reduced drastically and it's intrusion into the passenger cabin is zero, satisfying FMVSS 305. It is concluded that PEV's crashworthiness could be improved significantly through design process using hot forming steel, new design can provide much better mechanical integrity of the battery and reduced passenger cabin intrusion.
Thrombus Aspiration during Primary Percutaneous Coronary Intervention (2008)

Thrombus aspiration is applicable in a large majority of patients with myocardial infarction with ST-segment elevation, and it results in better reperfusion and clinical outcomes than conventional PCI, irrespective of clinical and angiographic characteristics at baseline. (Current Controlled Trials number, ISRCTN16716833.)
Increased Synthesis of Lactate Dehydrogenase "H" Subunit by a Malignant Tumor (1974)

Abstract In a patient with a rapidly growing malignant teratoma in the anterior mediastinum, the only biochemical abnormality detected at first was an abnormally high serum lactate dehydrogenase (EC 1.1.1.27) activity, almost 50% of the activity being present in lactate dehydrogenase isoenzyme-1 (LD1). At the time of death, the total lactate dehydrogenase activity had increased still further, 77% of it being in the LD1 fraction. Both the tumor and its hepatic metastases were shown to have a supranormally active LD1 fraction. These patterns appear to be attributable to an increased synthesis of the "H" subunit by the tumor.
Synthesis of 1,3-dioxin-4-ones and their use in synthesis. Part XXII. A novel synthetic method for tetronic acids from 1,3-dioxin-4-ones via intra- or intermolecular ketene trapping. (1990)

Novel synthetic routes to tetronic acid and its derivatives from 6-substituted 1, 3-dioxin-4-ones through cycloreversion to acylketenes followed by either intra- or intermolecular ketene trapping by a hydroxy function is described. While tetronic acid and its 5-substituted derivatives were synthesized directly from 6-(x-hydroxyalky)-1, 3-dioxin-4-ones by intramolecular trapping, 3-acyltetronic acids were prepared by Dieckmann reaction of the β-keto esters obtained from the 6-substituted dioxinones and an approptiate α-hydroxy ester by intermolecdular trapping.
An ISDN echo-cancelling transceiver chip set for 2B1Q coded U-interface (1989)

A three-chip set for a 2B1Q U-interface transceiver has been developed. The chip set is composed of an analog front-end (AFE), echo-canceller (EC), and receiver (RCV) LSIs. The AFE LSI includes a 12-b accuracy oversampling analog/digital converter. The EC and RCV LSIs are 26- and 16-bit microprogrammable digital signal processors, respectively. A digital phase-locked loop is used to minimize the analog part. Residual echo increase by a timing phase jump is compensated for by a newly introduced additional adaptive filter. Infinite impulse response filters and multiresponse filters reduce the necessary number of taps for both the echo canceller and the decision-feedback equalizer. The AFE and the two digital signal processor LSIs are implemented in 1.6- and 1.2- mu m double-metal layer CMOS processes, respectively. A 6-km loop coverage was realized with a less than 10/sup -7/ error rate. Total power consumption by the chip set is 580 mW at 5-V single supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Miscibility and isomorphic cocrystallization in blends of ferroelectric copolymers of vinylidene fluoride and trifluoroethylene (1990)

Abstract The miscibility in binary blends of ferroelectric copolymers of vinylidene fluoride (VF 2 ) and trifluoroethylene ( F 3 E) has been investigated over the full range of blend compositions for three different random copolymers containing 52, 65, or 73 mol % VF 2 . We found these copolymers miscible in the melt with each other but not with the parent homopolymer, PVF 2 . In thin solid films we demonstrated, for all blend compositions, the very rare phenomenon of isomorphic cocrystallization in both the ferroelectric and paraelectric phases of the 52 + 65 and the 65 + 73 mol % VF 2 copolymers. However, the blend having the largest compositional difference (52 + 73 mol % VF 2 ) was found to consist of two separate ferroelectric and paraelectric phases. These results demonstrate the very close chemical and structural similarities required for coexistence of two different macromolecules within a single crystalline lattice. Moreover, they allow us to probe the compositional limits for such similarity in both the ferroelectric and the paraelectric lattices. Phase diagrams of these blends have been constructed and are discussed. The Curie transition is shown to be an exceptionally sensitive probe of compatibility in the ferroelectric phase.
Induction of parathyroid hormone-related peptide by the Ras oncogene: role of Ras farnesylation inhibitors as potential therapeutic agents for hypercalcemia of malignancy. (1997)

Parathyroid hormone related peptide (PTHRP) is the major causal agent in the syndrome of malignancy-associated hypercalcemia (MAH). Several studies have shown that PTHRP production is increased in response to growth factors and oncogenes, such as Tpr-Met, that are associated with the tyrosine kinase signaling pathway. Using site-directed mutagenesis of Tpr-Met and chemical inhibitors of phosphotidylinositol-3 kinase and Ras isoprenylation, we demonstrated previously that induction of PTHRP is mediated via the Ras signaling pathway. In the present study, we have directly investigated the role of the Ras oncogene in MAH. As a model system, we used Fisher rat 3T3 fibroblasts stably transfected with a Ras oncogene (Ras-3T3). Ras transfection enhanced PTHRP production 5-10-fold in these cells, and inoculation of this cell line into nude mice led to the development of hypercalcemia within 2 weeks. We used this system to evaluate the effect of a potent inhibitor of Ras processing, B-1086, on cell growth, PTHRP production, plasma calcium, and tumor growth. Treatment of Ras-3T3 cells in vitro with B-1086 at 0.1-10 microg/ml produced a significant reduction in PTHRP mRNA expression and PTHRP secretion and a significant decrease in cell proliferation. Treatment in vivo of BALB/c/nu/nu mice bearing Ras-3T3 tumors with B-1086 resulted in a significant inhibition in tumor growth. In addition, this treatment produced near normalization of serum Ca2+, a significant decrease in plasma PTHRP, and a reduction in tumoral PTHRP mRNA levels. These results show that the Ras pathway is involved in PTHRP production by tumors, identifies Ras as a potential target for treatment of MAH, and demonstrates Ras processing inhibitors as candidate therapeutic agents against this syndrome.
New Approach Toward Fast Response Light‐Emitting Electrochemical Cells Based on Neutral Iridium Complexes via Cation Transport (2009)

Abstract Here, a new method is presented to increase the turn‐on time and stability of light‐emitting electrochemical cells (LECs). To this end, a neutral iridium complex ( 5 ) containing a pendant Na + ion that is generally known to have a faster mobility in the solid film than bulky anions is introduced, instead of the classic ionic transition metal complex (iTMC) with counter anion ( 7 ). Synthesis, photophysical and electrochemical studies of these complexes are reported. In the device configuration of ITO/ 5 or 7 +PEO (polyethylene oxide) (100–110 nm)/Au, as the voltage increases, complex 5 emits red light at −3.6 V while complex 7 appears at –5.6 V, although their electrochemical and photophysical gap are similar. Furthermore, at constant voltage, –3 V, the turn‐on time of complex 5 was less than 0.5 min, which is a 60‐fold faster turn‐on time compared to the iTMC ( 7 ) with PF 6 − . These results are presumably due to the faster delivery of the Na + ions to the electrode compared to PF 6 − ions. Also, the device lifetime of complex 5 exhibits a six‐fold increase in stability and a three‐fold shorter time to reach maximum brightness at constant bias compared to the device made with complex 7 .
Autonomous Optofluidic Chemical Analyzers for Marine Applications: Insights from the Submersible Autonomous Moored Instruments (SAMI) for pH and pCO2 (2018)

The commercial availability of inexpensive fiber optics and small volume pumps in the early 1990's provided the components necessary for the successful development of low power, low reagent consumption, autonomous optofluidic analyzers for marine applications. It was evident that to achieve calibration-free performance, reagent-based sensors would require frequent renewal of the reagent by pumping the reagent from an impermeable, inert reservoir to the sensing interface. Pumping also enabled measurement of a spectral blank further enhancing accuracy and stability. The first instrument that was developed based on this strategy, the Submersible Autonomous Moored Instrument for CO 2 (SAMI-CO 2 ), uses a pH indicator for measurement of the partial pressure of CO 2 (pCO 2 ). Because the pH indicator gives an optical response, the instrument requires an optofluidic design where the indicator is pumped into a gas permeable membrane and then to an optical cell for analysis. The pH indicator is periodically flushed from the optical cell by using a valve to switch from the pH indicator to a blank solution. Because of the small volume and low power light source, over 8,500 measurements can be obtained with a 500 mL reagent bag and 8 alkaline D-cell battery pack. The primary drawback is that the design is more complex compared to the single-ended electrode or optode that is envisioned as the ideal sensor. The SAMI technology has subsequently been used for the successful development of autonomous pH and total alkalinity analyzers. In this manuscript, we will discuss the pros and cons of the SAMI pCO 2 and pH optofluidic technology and highlight some past data sets and applications for studying the carbon cycle in aquatic ecosystems.
A soluble metalloendopeptidase from rat brain (1983)

A metalloendopeptidase, optimally active at a neutral pH, was purified from the soluble fraction of brain homogenates. The enzyme (molecular weight about 67000) is strongly inhibited by metal chelators such as EDTA and o-phenanthroline. An EDTA-treated enzyme can be reactivated by several divalent metal ions including Zn2+, Co2+ and Mn2+. The specificity and kinetic parameters of the enzyme were studied with a series of model synthetic substrates. The enzyme preferentially cleaves peptide bonds in which the carbonyl group is contributed by an aromatic amino acid residue in the P1 position. The lowest Km values and the highest Kcat/Km ratios were obtained with substrates having aromatic residues in the P'3 and P1 position or in the P'3 and both the P1 and P2 positions. Lower kcat/Km ratios were obtained with substrates having arginine residues in position P1, and even lower values with those substrates having a glycine or aspartyl residue in this position. Introduction of a D-amino acid residue in either position P1 or P'1 renders the substrate totally resistant to hydrolysis. The specificity studies suggest that the active site of the metalloendopeptidase can accommodate at least five amino acid residues, with two of those residues binding on the N-terminal side and three binding on the C-terminal side of the hydrolyzed bond. Several biologically active peptides are cleaved by the enzyme at sites consistent with the specificity deduced from studies with model synthetic substrates.
Development of plasma-based implant for silicon devices (2006)

Commercial usage of plasma-based implantation for silicon devices has commenced. This represents the culmination of decades of activity at universities, research labs, and finally semiconductor equipment manufacturers. The technique offers great potential for both economic benefits, as a much higher throughput process than traditional implant, as well as enabling new fabrication options for advanced CMOS, nonplanar implant, thin film formation and modification. This review of plasma-based implant for commercial semiconductor fabrication will focus on results thus far, current status, and the prospects for both implant and nonimplant applications. Due to the unique capabilities of plasma-based implantation for shallow depth and high dose, some discussion of metrology, diagnostics, and the process control needed for a manufacturing technology will be included.
Activation of the K-ras oncogene in colorectal neoplasms is Associated with decreased apoptosis (1997)

These findings suggest that activation of K-ras in colorectal carcinoma may inhibit apoptosis and thus favor tumor progression. Alternatively, this association may reflect an accumulation of K-ras mutations in cells in which normal apoptotic pathways have been impaired.
Synthesis and structural characterization of a silver complex of a mixed-donor N-heterocyclic carbene linked cyclophane (2001)

The synthesis of a dicationic imidazolium-linked cyclophane and a dimeric silver-N-heterocyclic carbene complex, that is the first silver complex with a N-heterocyclic carbene ligand involved in a pi-bonding interaction, is reported.
Curse of dimensionality in the application of pivot-based indexes to the similarity search problem (2009)

In this work we study the validity of the so-called curse of dimensionality for indexing of databases for similarity search. We perform an asymptotic analysis, with a test model based on a sequence of metric spaces (O d) from which we pick datasets Xd in an i.i.d. fashion. We call the subscript d the dimension of the space Od (e.g. for Rd the dimension is just the usual one) and we allow the size of the dataset n = nd to be such that d is superlogarithmic but subpolynomial in n. We study the asymptotic performance of pivot-based indexing schemes where the number of pivots is o(n/d). We pick the relatively simple cost model of similarity search where we count each distance calculation as a single computation and disregard the rest. We demonstrate that if the spaces Od exhibit the (fairly common) concentration of measure phenomenon the performance of similarity search using such indexes is asymptotically linear in n. That is for large enough d the difference between using such an index and performing a search without an index at all is negligeable. Thus we confirm the curse of dimensionality in this setting.