gebhart/patrepeval huggingface dataset:
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Does Not Affect Changes in Strength or Body Composition during Resistance Training in Trained Men (2001)

This investigation evaluated the effects of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation on training responses in resistance-trained male athletes who were randomly administered HMB in standard encapsulation (SH), HMB in time release capsule (TRH), or placebo (P) in a double-blind fashion. Subjects ingested 3 g x day(-1) of HMB or placebo for 6 weeks. Tests were conducted pre-supplementation and following 3 and 6 weeks of supplementation. The testing battery assessed body mass, body composition (using dual energy x-ray absorptiometry), and 3-repetition maximum isoinertial strength, plus biochemical parameters, including markers of muscle damage and muscle protein turnover. While the training and dietary intervention of the investigation resulted in significant strength gains (p < .001) and an increase in total lean mass (p = .01), HMB administration had no influence on these variables. Likewise, biochemical markers of muscle protein turnover and muscle damage were also unaffected by HMB supplementation. The data indicate that 6 weeks of HMB supplementation in either SH or TRH form does not influence changes in strength and body composition in response to resistance training in strength-trained athletes.
Peroxisome proliferator‐activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle (2003)

The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. The three isoforms (PPARalpha, beta/delta and gamma) have been implicated in the regulation of the expression of genes involved in lipid metabolism. Although their prominent role in lipid homeostasis is well established, the way in which the activity of each of the PPAR isoforms is regulated under physiological and pathological conditions is still subject of intensive research. In skeletal as well as cardiac muscle cells it has been demonstrated that the expression of a large panel of proteins involved in the transport and metabolic conversion of fatty acids is under control of PPARs. The pivotal role of the PPARalpha isoform in cardiac fatty acid metabolism has been confirmed in PPARalpha-null mice. The exact role of PPARbeta/delta in the regulation of muscle metabolism is still a matter of debate. Whereas several studies provided evidence to support the notion that PPARalpha and PPARbeta/delta have redundant roles, other studies suggest that PPARalpha activity is counteracted by PPARbeta/delta. Marked effects of bona fide PPARgamma ligands (the anti-diabetic thiazolidinediones) on skeletal and cardiac muscle function and phenotype, have also been reported. However, next to activating PPARgamma, the thiazolidinediones do affect other cellular processes as well. To date it is being realized that the control of the trans-activating capacity of each of the PPAR isoforms is multi-factorial and, in addition to ligand availability, depends on such factors as isoform-specific phosphorylation and selective interaction with various proteins acting either as co-activator or co-repressor.
Degenerate noncollinear emission from a type I collinear parametric oscillator (2001)

Noncollinear emission occurs in a free running type I parametric oscillator beyond the theoretical tuning curve for collinear oscillation. The noncollinear emission is described in terms of the emission angle and the corresponding angle of divergence. Experimentally recorded single captures of the transverse profile for the noncollinear regime are presented. A theoretical description of the degenerate tuning is described to explain the noncollinear regime.
Regulation of glycogen phosphorylase activity in isolated human hepatocytes (1993)

Hepatocytes were isolated from human liver tissue by a two-step perfusion technique. They were treated with vasopressin, angiotensin, ATP and phenylephrine, which are known to be Ca(2+)-mediated glycogenolytic agents in rat liver tissue, and as a control, they were treated with the cyclic AMP-mediated hormones glucagon and isoproterenol. All agonists induce a time-dependent activation of glycogen phosphorylase. Glucagon and isoproterenol induce a somewhat higher degree of phosphorylase activation compared with vasopressin, angiotensin, ATP and phenylephrine, which all increase inositol tris-phosphate levels and have no effect on the cyclic AMP levels. The total activity of glycogen phosphorylase (a + b), amounting to 30 to 35 mU/mg protein, is found to be much lower than that found in rat liver tissue. Because only minor differences could be found, we conclude that the regulation of glycogen phosphorylase in human liver tissue is basically the same as that found in rat liver tissue.
Bias of a resonator fiber optic gyro composed of a polarization-maintaining fiber ring resonator with the photoinduced birefringent grating (2002)

A theoretical study of the polarization-fluctuation induced bias of an resonator fiber optic gyro (R-FOG), which employs a polarization-maintaining fiber ring resonator with a photoinduced birefringent grating, is presented. The polarization conversion due to the photoinduced birefringent grating can stabilize the resonator output, which result in the reduction of the bias in the R-FOG output. The influences of the parameters, such as the fluctuation of the input polarization, the resonator finesse, and the photoinduced index change of the dielectric tensor, on the bias of the gyro-output have been investigated. Our results show that with the help of a photoinduced birefringent grating the bias of the gyro-output can be limited in the order of 10/sup -7/ rad/s, a typical specification for the aircraft-navigation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Case Report of Obturator Hernia Diagnosed Preoperatively by Computed Tomography. (1992)

閉鎖孔ヘルニアは, 比較的まれな疾患で, 術前診断率も低い.今回われわれはcomputed tomography (以下CT) により術前に診断しえた閉鎖孔ヘルニアの1例を経験したので報告する.症例は80歳, 女性で, 腹痛, 嘔吐, 右大腿部痛を訴えて来院.閉鎖孔ヘルニアを疑い, 骨盤部CTを行ったところ, 右閉鎖孔部に一致して腫瘤像を認めたので閉鎖孔ヘルニアと確定し, 根治手術を施行した.原因不明の高齢なイレウス患者に対して本症を疑った場合には, 早期診断にきわめて有用なCT検査を積極的に行うべきである.
Chemically induced shifts in the photoluminescence spectra of porous silicon (1993)

The observation of photoluminescence (PL) spectral shifts during anodization of porous Si and after immersion in different chemical solutions is reported. These shifts in the PL spectra are attributed to changes in the surface chemistry achieved by changing the composition of the electrolyte in which the samples are immersed. Using this approach the emission has been repeatedly cycled (≳100 times) between green and red.
CaPSSA: visual evaluation of cancer biomarker genes for patient stratification and survival analysis using mutation and expression data (2019)

Supplementary data are available at Bioinformatics online.
Cased Hole Formation Resistivity Tool Trial (2001)

Abstract In the past hydrocarbon saturation have been monitored behind casing by pulsed neutron capture (PNC) logs. These tools have been quite successful in our environment onshore Abu Dhabi characterized by good porosity carbonate reservoirs with high salinity waters. The ability to measure formation resistivity directly through casing in monitoring wells adds a new dimension, by allowing the measurement of water saturation further away from the borehole, less affected by the "damaged zone" invaded by mud filtrate and drilling fines. Until recently, resistivity logging in cased hole has been restricted to Induction logs in fiberglass lined wells. New advances in digital electronics has made it possible to produce the sufficiently accurate and stable downhole sensors required to measure formation resistivity through steel casing. The first Middle East trials of a new Cased Hole Formation Resistivity Tool (CHFR) took place in 1999/2000 in several ADCO wells. Monitoring fluid saturation changes and movement in fluid contacts with time, including the identification of swept zones, barriers to flow and bypassed oil are the main applications for the CHFR. With a greater dynamic range than PNC-logs, the CHFR will complement data from sponge cores and open hole logs in swept zones, leading to more robust ROS determination. The CHFR may also be used for primary evaluation, where no logs could be acquired in open hole, and allows re-examination of wells with old resistivity logs. In low resistivity where the CHFR is near it’s specified limit of 1 Ohmm, the effects of resistive cement behind casing become important and require careful correction. PNC-logs are favored in this low resistivity range. Field logs obtained in this trial will be presented and discussed in the paper.
Ultra‐Sensitive Graphene‐Plasmonic Hybrid Platform for Label‐Free Detection (2013)

A graphene-Au nano-pyramid hybrid system that enables label-free single molecule detection is demonstrated. The bio-compatible graphene-based SERS platform boosts a high density of hot spots with local SERS enhancement factor over 10(10) . We demonstrate that graphene can play a key role in quantitative study of SERS mechanisms, and can also serve as a promising building block in SERS active structures especially for biosensor applications.
Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells (2015)

Maintenance and differentiation of human pluripotent stem cells (hPSCs) usually requires culture on a substrate for cell adhesion. A commonly used substratum is Matrigel purified from Engelbreth-Holm-Swarm sarcoma cells, and consists of a complex mixture of extracellular matrix proteins, proteoglycans, and growth factors. Several studies have successfully induced differentiation of hepatocyte-like cells from hPSCs. However, most of these studies have used Matrigel as a cell adhesion substrate, which is not a defined culture condition. In an attempt to generate a substratum that supports undifferentiated properties and differentiation into hepatic lineage cells, we designed novel substrates consisting of vitronectin fragments fused to the IgG Fc domain. hPSCs adhered to these substrates via interactions between integrins and the RGD (Arg-Gly-Asp) motif, and the cells maintained their undifferentiated phenotypes. Using a previously established differentiation protocol, hPSCs were efficiently differentiated into mesendodermal and hepatic lineage cells on a vitronectin fragment-containing substrate. We found that full-length vitronectin did not support stable cell adhesion during the specification stage. Furthermore, the vitronectin fragment with the minimal RGD-containing domain was sufficient for differentiation of human induced pluripotent stem cells into hepatic lineage cells under completely defined conditions that facilitate the clinical application of cells differentiated from hPSCs.
2′‐Deoxy‐2′‐azidocytidine, a New Inhibitor of DNA Replication in Mammalian Cells (1977)

Cell growth is reversibly inhibited by the nucleoside analogue, 2'-deoxy-2'-azidocytidine and the inhibition is a result of interference with DNA replication. The 5'-diphosphate of the analogue was earlier shown to specifically inactivate the enzyme ribonucleotide reductase in vitro. However, measurements of the pools of deoxyribonucleoside triphosphates in cells incubated in azidocytidine showed only minor changes which appeared to result from and not to be the cause of the inhibition of DNA replication. The DNA synthesized in polyoma-infected cells after incubation in azidocytidine showed a sedimentation pattern quite different from that seen after inhibition of DNA synthesis with arabinosyl cytosine or hydroxyurea. Experiments with nuclei isolated from azidocytidine-inhibited, polyoma-infected cells indicated (a) that the number of replicating molecules is decreased during the inhibition and (b) that upon incubation of the nuclei there is a rapid synthesis of DNA occurring in a new class of DNA molecules which are at a very early state of replication. Neither the 5'-triphosphate of azidocytidine nor the nucleoside itself inhibit DNA synthesis in vitro in isolated nuclei from polyoma-infected cells and at present the nature of the DNA-synthesis-inhibiting compound acting in the cells after addition of azidocytidine is unknown. Taken together the results suggest that azidocytidine inhibits DNA synthesis at an early stage, possible by blocking the initiation of DNA synthesis at the origin or by interfering with the elongation of newly initiated DNA molecules.
Quality of service in an information-centric network (2014)

QoS provisioning is one of the key challenges facing current as well as future Internet architectures. Its dependency on content recognition does not allow a straightforward support of QoS in the IP, host-centric, model. In contrast, Information-Centric Networking (ICN) offers native content identification in the network, which can be exploited to develop a common, elegant, framework for supporting QoS-based delivery. Therefore, ICN may naturally overcome many of the cumbersome fixes and limitations of today's solutions. In this work, we exploit the flexibility in semantic representation offered by ICN to present a flexible and scalable ICN-based QoS model. Our model defines QoS requirements as information items that can be linked to the content at various aggregation levels, independent of the communication approach. Therefore, it can be applied uniformly to various network types and hierarchies. Furthermore, our model offers enhanced traffic treatment as well as resource utilization while significantly reducing the overhead on the network.
El mito de la literatura como configuración de una identidad cultural (A propósito de una novela de J. J. Armas Marcelo) (1999)

El mito ha sido y es una de las claves de la cultura de Canarias. Desde el mito platónico de la Atlántida, se han generado hasta nuestros días diversos mitos que han encontrado en la literatura un soporte ideal para su difusión y para su recreación. De este modo, la literatura ha servido para registrar la identificación que una cultura lleva a cabo a través de una de sus manifestaciones más singulares. Por otra parte, el mito capta la atención del lector, cuestión siempre importante en la enseñanza de la literatura. En este trabajo pretendemos ejemplificar con el estudio de Madrid, Distrito Federal -una novela del autor canario J. J. Armas Marcelo- la implicación del mito en la literatura como referente de la cultura en la que se integra.
The Honorable Frank Haswell (1991)

The Honorable Frank Haswell
Antigen Binding to Cells: Determination by Enzymic Fluorogenic Group Hydrolysis (1968)

A sensitive method for detecting cells containing antibody to beta-galactosidase has been devised. The enzyme attached to the cells containing antibody can hydrolyze a fluorogenic substrate and yield fluorescent products which are measured microphotofluorometrically. This method of detecting a few molecules of antibody is applicable to other enzyme antigen systems.
Exploiting Small Leakages in Masks to Turn a Second‐Order Attack into a First‐Order Attack and Improved Rotating Substitution Box Masking with Linear Code Cosets (2015)

Masking countermeasures, used to thwart side-channel attacks, have been shown to be vulnerable to mask-extraction attacks. State-of-the-art mask-extraction attacks on the Advanced Encryption Standard (AES) algorithm target S-Box recomputation schemes but have not been applied to scenarios where S-Boxes are precomputed offline. We propose an attack targeting precomputed S-Boxes stored in nonvolatile memory. Our attack targets AES implemented in software protected by a low entropy masking scheme and recovers the masks with 91% success rate. Recovering the secret key requires fewer power traces (in fact, by at least two orders of magnitude) compared to a classical second-order attack. Moreover, we show that this attack remains viable in a noisy environment or with a reduced number of leakage points. Eventually, we specify a method to enhance the countermeasure by selecting a suitable coset of the masks set.
Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma (2008)

To develop peptide-based immunotherapy for osteosarcoma, we previously identified papillomavirus binding factor (PBF) as a cytotoxic T lymphocytes (CTL)-defined osteosarcoma antigen in the context of human leukocyte antigen (HLA)-B55. In the present study, we analyzed the distribution profile of PBF in 83 biopsy specimens of osteosarcomas and also the prognostic impact of PBF expression in 78 patients with osteosarcoma who had completed the standard treatment protocols. Next, we determined the antigenic peptides from PBF that react with peripheral T lymphocytes of HLA-A24(+) patients with osteosarcoma. Immunohistochemical analysis revealed that 92% of biopsy specimens of osteosarcoma expressed PBF. PBF-positive osteosarcoma conferred significantly poorer prognosis than those with negative expression of PBF (P = 0.025). In accordance with the Bioinformatics and Molecular Analysis Section score, we synthesized 10 peptides from the PBF sequence. Subsequent screening with an HLA class I stabilization assay revealed that peptide PBF A24.2 had the highest affinity to HLA-A24. CD8(+) T cells reacting with a PBF A24.2 peptide were detected in eight of nine HLA-A24-positive patients with osteosarcoma at the frequency from 5 x 10(-7) to 7 x 10(-6) using limiting dilution/mixed lymphocyte peptide culture followed by tetramer-based frequency analysis. PBF A24.2 peptide induced CTL lines from an HLA-A24-positive patient, which specifically killed an osteosarcoma cell line that expresses both PBF and HLA-A24. These findings suggested prognostic significance and immunodominancy of PBF in patients with osteosarcoma. PBF is the candidate target for immunotherapy in patients with osteosarcoma.
Theoretical and experimental sensitivities of ESR spectrometers using maser techniques (1973)

We have considered theoretically and experimentally a paramagnetic resonance spectrometer, whose cavity contains both the sample to be studied and a beam of ammonia molecules capable of stimulated emission. Different modes of operation are investigated: classical, ``Q-multiplier'' and marginal oscillator spectrometer. In these two latter cases, the ultimate sensitivity is determined only by the thermal noise in the cavity. It is shown to be the theoretical sensitivity of a spectrometer using a perfect receiver. This sensitivity can be achieved if the stored energy does not exceed an upper limit, depending on properties of the active molecules-typically 5 × 10−18 J for NH3.
The state of the art in the growth of diamond crystals and films (2006)

This review focuses on high-pressure diamond synthesis processes, some of which have been used in commercial-scale production of diamond powder and large single crystals for more than forty years now, and on the role and types of vapor-phase activation in rapidly developing technologies of diamond films and wafers—excellent candidates for near-term industrial application.
Miniature fiber-optic force sensor for vitreoretinal microsurgery based on low-coherence Fabry-Pérot interferometry (2012)

Vitreoretinal surgery requires delicate manipulation of retinal tissue. However, tool-to-tissue interaction forces in the order of sub-millinewton are usually below the human sensory threshold. A surgical force sensor (FS) compatible with conventional surgical tools may significantly improve the surgery outcome by preventing tissue damage. We have designed and built a miniature FS for vitreoretinal surgery using a fiber-optic common-path phase-sensitive optical coherence tomography (OCT) system where the distal end of the fiber probe forms a low-finesse Fabry-Pérot (FP) cavity between the cleaved tip of the lead-in single mode fiber and the polished back surface of a stainless steel surgical tool tip. To accurately measure the change of the FP cavity length, the cavity is interrogated by the fiber-optic common-path phase-sensitive OCT. The FP cavity was illuminated with a broadband light source, and the interferometric signal was detected using a broadband spectrometer. The phase of the interferometric signal, which is proportional to the cavity length change as well as the exerted force, was extracted. We have conducted calibration experiments to characterize our one dimensional FS. Our result shows that the FS responses linearly to force in axial direction with force sensitivity better than 0.25 millinewton.
Computer Simulation Studies of Bulk Reduction and Oxygen Migration in CeO<sub>2</sub>−ZrO<sub>2</sub>Solid Solutions (1997)

Computer simulation techniques have been used to model cubic CeO2−ZrO2 solid solutions in the whole composition range. Aspects related with the oxygen storage capacity of these materials are emphasized. The energetics of the Ce4+/Ce3+ bulk reduction reaction as well as the activation energy for oxygen migration in the lattice are investigated and compared with the corresponding quantities in pure CeO2. It is found that even small additions of ZrO2 decrease the bulk reduction energy of Ce4+ to values comparable to those reported for surface reduction in pure CeO2. Activation energy calculations indicate an almost monotonic increase of oxygen mobility with increasing zirconia content.
Control techniques for power factor correction converters (1994)

Abstract. The aspects regarding control strategies for Power Factor Correction (PFC) converters are investigated. The major control techniques to absorb sinusoidal input currents in boost PFC&apos;s are reviewed and analyzed. Their extension to other converter topologies is discussed and some experimental results for a PFC based on the Sepic topology are reported, which allow comparison of converter performance with different control techniques. Lastly, some considerations regarding dynamic operation are given, together with information about control IC&apos;s specifically developed for PFC applications.
Murcielagos hematófagos y su importancia médica en Panamá (1972)

Murcielagos hematofagos y su importancia medica en Panama , Murcielagos hematofagos y su importancia medica en Panama , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding site (1992)

The human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins induce cytoplasmic expression of incompletely spliced viral mRNAs by binding to these mRNAs in the nucleus. Each protein binds a specific cis-acting element in its target RNAs. Both proteins also associated with nucleoli, but the significance of this association is uncertain because mutations that inactivate nucleolar localization signals in Rev or Rex also prevent RNA binding. Here we demonstrate that Rev and Rex can function when tethered to a heterologous RNA binding site by a bacteriophage protein. Under these conditions, cytoplasmic accumulation of unspliced RNA occurs without the viral response elements, mutations in the RNA binding domain of Rev do not inhibit function, and nucleolar localization can be shown to be unnecessary for the biological response.
Credit-based flow control for ATM networks (1995)

Simulation, analysis, and experiments on switching hardware have shown that for a wide variety of traffic patterns, credit control is fair, uses links efficiently, minimizes delay, and guarantees no cell loss due to congestion. The credit-based mechanism proposed by the authors provides flow control tailored to ATM networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>