gebhart/patrepeval huggingface dataset:
The development of explosion puffing (1984)

The historical development and characteristics of the explosion-puffing (EP) process for dehydrating foods are reviewed. The process, developed about 1962, EP into a hot-air dehydration process. The EP technique was devised to yield a product similar to freeze-drying, with faster subsequent rehydration, retention of texture and flavor of fresh-cooked food, and lower unit processing costs. The technique produces low-moisture (below 4%) fruit or vegetable pieces, and makes the processing of relatively large pieces (e.g., 1.9 cm cubes) feasible. A schematic of the technique is included. (wz)
Study of the System CaCl<sub>2</sub>-ZnCl<sub>2</sub>-H<sub>2</sub>O (NaCl Saturated) at 15° C. (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of the System CaCl2-ZnCl2-H2O (NaCl Saturated) at 15° C.E. P. Helvenston and E. A. CuevasCite this: J. Chem. Eng. Data 1964, 9, 3, 321–323Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/je60022a001https://doi.org/10.1021/je60022a001research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Love, hate, truth and death: Marlene's story (1996)

I worked with Marlene in psychoanalytical psychotherapy, over the course of nine years (1982-1990). I was supervised by RD Laing during the first 3 years. Based on my clinical work at the time this paper is, inevitably, somewhat revealing, more than a purely theoretical paper. I think this is true to the spirit of psychoanalysis, that we should be as open as we can afford to be. Marlene was one of my most articulate patients and, at the same time, gave me one of the most intense emotional experiences I've ever had, especially professionally. I still find it difficult to gain a measure of distance or separateness from the events of the time, in order to see them clearly. (non-author abstract)
Tuning the Adsorption Interactions of Imidazole Derivatives with Specific Metal Cations (2014)

In this work, we report a computational study of the interactions between metal cations and imidazole derivatives in the gas phase. We first performed a systematic assessment of various density functionals and basis sets for predicting the binding energies between metal cations and the imidazoles. We find that the M11L functional in combination with the 6-311++G(d,p) basis set provides the best compromise between accuracy and computational cost with our metal···imidazole complexes. We then evaluated the binding of a series of metal cations, including Li(+), Na(+), K(+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), Ba(2+), Hg(2+), and Pb(2+), with several substituted imidazole derivatives. We find that electron-donating groups increase the metal-binding energy, whereas electron-withdrawing groups decrease the metal-binding energy. Furthermore, the binding energy trends can be rationalized by the hardness of the metal cations and imidazole derivatives, providing a quick way to estimate the metal···imidazole binding strength. This insight can enable efficient screening protocols for identifying effective imidazole-based solvents and membranes for metal adsorption and provide a framework for understanding metal···imidazole interactions in biological systems.
The British Leyland 2S/350/R Gas Turbine Engine (1974)

Experience gained on a number of gas turbine powered heavy trucks indicated that the conventional engine configuration could be considerably improved. Aspects of engine reliability, and access to the heat exchangers and vehicle ancilliaries led to the desirability of an alternative engine layout. At the same time, development of components reached the stage where further performance improvements were hampered by engine constraints — for example, the ducting between the compressor and the heat exchangers, and the size and distribution of the accessory loads. The most satisfactory solution to these requirements has been to adopt a single heat exchanger engine concept, since this also showed a considerable reduction in engine cost while the fuel consumption penalty is only marginal in practice. The resultant engine is described, giving significant design features and performance data.
Ultrasonic Based Proximity Detection for Handsets (2018)

A novel approach for proximity detection on mobile handsets which does not require any additional transducers is presented. The method is based on transmitting a chirp and processing the received signal by applying Least Mean Square (LMS), where the desired signal is the transmitted chirp. The envelope of three signals (estimated filter taps, estimated output and error signal) are characterized with a set of 12 features which are used to classify a given frame into one of two classes: proximity active or proximity inactive. The classifier employed is based on Support Vector Machine (SVM) with linear kernel. The results show that over 13 minutes of recorded data, the accuracy achieved is 95.28% using 10-fold cross-validation. Furthermore, the feature importance analysis performed on the database indicates that the most relevant feature is based on the estimated filter taps.
Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. (1989)

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.
Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease (1996)

The phosphorylation of human phenylalanine hydroxylase by cyclic AMP-dependent protein kinase was studied using recombinant enzyme expressed as a fusion protein in the pMAL system of Escherichia coli. Using the target sequence of the restriction protease enterokinase (Asp4-Lys) as the linker peptide, 100% full-length human phenylalanine hydroxylase was obtained on protease cleavage. The fusion protein and human phenylalanine hydroxylase were both phosphorylated at Ser-16 with a stoichiometry of 1 mol of Pi/mol of subunit. The rate of phosphorylation of human phenylalanine hydroxylase was inhibited about 40% by the cofactor tetrahydrobiopterin, and this inhibition was completely prevented by the simultaneous presence of L-phenylalanine (i.e. at turnover conditions). Phosphorylated enzyme revealed a 1.6-fold higher specific activity than the non-phosphorylated enzyme form, and it also required a lower concentration of L-Phe for substrate activation. Pre-incubation with L-Phe increased the specific activity of phenylalanine hydroxylase 2- to 4-fold, L-Phe acting with positive cooperativity. Thus, the basic catalytic and regulatory properties of recombinant human phenylalanine hydroxylase, as well as those observed for the enzyme as a fusion protein, are similar to those previously reported for the rat liver enzyme. When the target sequence of the restriction protease factor Xa (Ile-Glu-Gly-Arg) was used as the linker between maltose-binding protein and human phenylalanine hydroxylase, cleavage of the fusion protein gave a mixture of full-length hydroxylase and a truncated form of the enzyme lacking the 13 N-terminal residues. Interestingly, phosphorylation of the fusion protein, before exposure to factor Xa, almost completely protected against secondary cleavage by this restriction protease at Arg-13 of phenylalanine hydroxylase.
Pattern of Cerebral Hypoperfusion in Alzheimer Disease and Mild Cognitive Impairment Measured with Arterial Spin-labeling MR Imaging: Initial Experience (2005)

Arterial spin-labeling MR imaging showed regional hypoperfusion with AD, in brain regions similar to those seen in FDG PET and HMPAO SPECT studies of similar populations; this hypoperfusion persists after accounting for underlying cortical gray matter atrophy.
Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. (1988)

Since melatonin, the major hormone of the pineal gland, has been shown to inhibit the growth of mammary tumors in animal models of human breast cancer, we examined the hypothesis that this indoleamine has the potential to inhibit breast cancer growth by directly inhibiting cell proliferation as exemplified by the growth of the estrogen-responsive human breast cancer cell line MCF-7 in culture. Concentrations of melatonin (10(-9) M; 10(-11) M), corresponding to the physiological levels present in human blood during the evening hours, significantly inhibited (P less than 0.001) cell proliferation by as much as 60% to 78% as measured by either DNA content or hemocytometer cell counts. Melatonin's inhibitory effect was reversible since the logarithmic growth of MCF-7 cells was restored after melatonin-containing medium was replaced with fresh medium lacking melatonin. Not only was the inhibitory effect of melatonin absent at either pharmacological (10(-7) M; 10(-5) M) or subphysiological (10(-15) M; 10(-13) M) concentrations, but melatonin also failed to inhibit the proliferation of either human foreskin fibroblasts or the estrogen receptor-positive human endometrial cancer cell line RL95-2. Both transmission and scanning electron microscopy revealed several morphological changes that correlated with melatonin's inhibition of cell growth. After just 4 days of exposure to melatonin, MCF-7 cells exhibited reduced numbers of surface microvilli, nuclear swelling, cytoplasmic and ribosomal shedding, disruption of mitochondrial cristae, vesiculation of the smooth endoplasmic reticulum, and an increase in the numbers of autophagic vacuoles. These results support the hypothesis that melatonin, at physiological concentrations, exerts a direct but reversible, antiproliferative effect on MCF-7 cell growth in culture. This antiproliferative effect is associated with striking changes in the ultrastructural features of these cells suggestive of a sublethal but reversible cellular injury.
Interaction of glyphosate with postemergence soybean (<i>Glycine max</i>) herbicides (1997)

Greenhouse and field experiments were conducted to evaluate the potential for antagonistic or synergistic interactions from tank mixtures of glyphosate plus a selective herbicide applied postemergence. In the greenhouse, glyphosate at 420 g ae ha −1 plus 28% liquid urea-ammonium nitrate (28% UAN) provided at least 89% control of common lambsquarters and common ragweed. Glyphosate at 1,680 g ha −1 plus 28% UAN provided less than 81% control of velvetleaf and less than 75% control of ivyleaf morningglory. Tank mixing bentazon at 1,120 g ai ha −1 with glyphosate at 420 g ha −1 synergistically increased control of velvetleaf. Tank mixtures of glyphosate plus a selective herbicide were predominately additive in control of common lambsquarters, common ragweed, and velvetleaf. Several tank mix combinations of chlorimuron or imazethapyr plus glyphosate plus 28% UAN were antagonistic in control of ivyleaf morningglory. In the field, glyphosate at 840 g ha −1 plus 28% UAN provided at least 88% control of common lambsquarters and velvetleaf in 1994. However, glyphosate at 840 g ha −1 plus 28% UAN provided only 60% control of velvetleaf in 1995. Tank-mixing bentazon or CGA-248757 with glyphosate at 420 g ha −1 increased velvetleaf and common lambsquarters control in 1995. In general, adding chlorimuron, imazethapyr, or thifensulfuron to glyphosate plus 28% UAN did not increase control of common lambsquarters or velvetleaf. Tank mixing imazethapyr with glyphosate plus 28% UAN antagonized velvetleaf control in 1994 and in 1995. The tank mixture of thifensulfuron at 2 g ha −1 plus glyphosate at 420 g ha −1 plus 28% UAN increased soybean injury in the field in 1994. However, tank mixing chlorimuron, imazethapyr, or thifensulfuron with glyphosate plus 28% UAN did not increase soybean injury in the greenhouse or in the field in 1995.
Developing a consistent view on emotion-oriented computing (2005)

The network of excellence HUMAINE is currently making a co-ordinated, interdisciplinary effort to develop a consistent view on emotion-oriented computing. This overview paper proposes a “map” of the research area, distinguishing core technologies from applicationoriented and psychologically oriented work. First results from the ongoing research in the thematic workpackages are reported.
Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol (1974)

Of 47 steroid compounds tested for their ability to suppress 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts, 11 were more potent than cholesterol. The only consistent structural requirement for suppression of enzyme activity was the presence of an unesterified oxygen function at position 3 of the sterol nucleus. The presence of a ketone or hydroxyl group at positions 6, 7, or 25 markedly enhanced inhibitory activity. In fibroblasts from a homozygote with familial hypercholesterolemia, which are genetically resistant to physiological enzyme suppression by cholesterol contained in low density lipoproteins, 3-hydroxy-3-methylglutaryl coenzyme A reductase activity was suppressed by nonlipoprotein steroids to the same degree as in normal cells. 7-Ketocholesterol, which was 100 times more potent than cholesterol on a weight basis, suppressed enzyme activity in normal cells by more than 90% in 2 hours. This inhibition was reflected in a similarly marked decrease in the rate of incorporation of acetate, but not mevalonate into digitonin-precipitable sterols. When normal cells were cultured in the presence of 7-ketocholesterol but in the absence of lipoproteins, the suppression of endogenous cholesterol synthesis by 7-ketocholesterol resulted in a marked inhibition of cell growth. This inhibition of growth was prevented by the presence in the culture medium of either cholesterol or mevalonate, but not acetate. Thus, the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase became the rate-limiting factor both for cholesterogenesis and for growth of fibroblasts under conditions where exogenous cholesterol was not available to the cells. It is concluded that 7-ketocholesterol may provide a powerful tool for delineation of the mechanism by which cholesterol and other steroids promote the growth of human cells in culture.
Pupillary Device Design For Ocular Cranial Nerve Monitoring (2018)

Inspection of the pupillary reflex and extraocular motor function can provide invaluable information about the integrity of the cranial nerves, as well as indirectly indicate changes in intracranial pressure (ICP). In critical ICU patients and patients with severe traumatic brain injuries (TBI), monitoring these physiological mechanisms has shown that dysfunction may be proportional to the degree of injury. In the operating room, current devices for reflex pupillometry are based on 40-year-old technology, measure at irregular intervals, and require logistically difficult manipulations. In this thesis, a prototype device design is proposed that can be positioned on or nearly on-eye and provide continuous measurement of both ipsilateral and contralateral pupil responses simultaneously in real-time or near real-time while being minimally invasive. The primary application of this device is in neurosurgery, emergency medicine, and telemedicine.
Modulating Image Restoration with Continual Levels via Adaptive Feature Modification Layers (2019)

In image restoration tasks, like denoising and super resolution, continual modulation of restoration levels is of great importance for real-world applications, but has failed most of existing deep learning based image restoration methods. Learning from discrete and fixed restoration levels, deep models cannot be easily generalized to data of continuous and unseen levels. This topic is rarely touched in literature, due to the difficulty of modulating well-trained models with certain hyper-parameters. We make a step forward by proposing a unified CNN framework that consists of few additional parameters than a single-level model yet could handle arbitrary restoration levels between a start and an end level. The additional module, namely AdaFM layer, performs channel-wise feature modification, and can adapt a model to another restoration level with high accuracy. By simply tweaking an interpolation coefficient, the intermediate model - AdaFM-Net could generate smooth and continuous restoration effects without artifacts. Extensive experiments on three image restoration tasks demonstrate the effectiveness of both model training and modulation testing. Besides, we carefully investigate the properties of AdaFM layers, providing a detailed guidance on the usage of the proposed method.
ASP: a cost-effective parallel microcomputer (1988)

The author presents ASP architecture, which offers cost-effective support of a wide range of numerical and nonnumerical computing applications, using state-of-the-art microelectronic technology to achieve processor packing densities that are more usually associated with memory components, ASP is designed to benefit from the inevitable VLSI-to-ULSI-to-WSI (very large, ultra large, and wafer-scale integration) technological trend, with a fully integrated, simply scalable, and defect/fault-tolerant processor interconnection strategy. The author discusses the architectural philosophy, structural organization, operational principles, and VLSI/ULSI/WSI implementation of ASP and indicates its cost-performance potential. ASP microcomputers have the potential to achieve cost-performance targets in the range of 100 to 1000 MOPS (million operations per second) per $1000. This gives ASPs an advantage of two to three orders of magnitude over current parallel computer architectures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simultaneous recording of xylem pressure and trans‐root potential in roots of intact glycophytes using a novel xylem pressure probe technique (1998)

The radial electrical potential difference between the root xylem and the bathing solution, i.e. the so‐called trans‐root potential, was measured in intact maize and wheat plants using a xylem pressure probe into which an Ag/AgCl electrode was incorporated. Besides other advantages (e.g. detection and removal of tip clogging; determination of the radial root resistance), the novel probe allowed placement of the electrode precisely in a single xylem vessel as indicated by the reading of sub‐atmospheric or negative pressure values upon penetration. The trans‐root potentials were of the order of 0 to – 70 mV and + 40 to – 20 mV for 2‐ to 3‐week‐old maize and wheat plants, respectively. Osmotic experiments performed on maize demonstrated that addition of 100 m M mannitol to the solution resulted in a decrease of xylem pressure associated with a slow, but continuous depolarization. The depolarization was reversible upon removal of the mannitol. For wheat plants it could be shown that the oscillations of the xylem pressure described recently by Schneider et al. (1997, Plant, Cell and Environment 20, 221–229) were accompanied by (rectangular, saw‐tooth and/or U‐shaped) oscillations in the trans‐root potential (but not by corresponding changes of the membrane potential of the cortical cells measured simultaneously with conventional microelectrodes). Increase of the light intensity (up to 550 μ mol m –2 s –1 ) resulted in a drop of the xylem pressure in wheat, whereas the trans‐root potential showed a biphasic response: first hyperpolarization (by about 10 mV) was observed, followed by depolarization (by up to about + 40 mV). Similar light‐induced biphasic (but often less pronounced) changes in the trans‐root potential were also recorded for maize plants. Most interestingly, the response of the trans‐root potential was always faster (by about 1–3 min) than the response of the xylem pressure upon illumination, suggesting that changes in the transpiration rate are reflected very quickly in the electrical properties of the root tissue. The impact of this and other findings on long‐distance transport of solutes and water as well as on long‐distance signalling is discussed.
Design as an Integrated Process: Haley Sharpe Associates – Ten Years on (2004)

At the heart of any successful competitive strategy lies a set of distinctive competencies that form the basis of a firm's source of sustainable advantage. One increasingly valued but still frequently overlooked source of such advantage is design. The benefits of design investment at a strategic level to greatly assist competitiveness are well publicized (Cooper and Press, 1995; Walsh et al, 1992; Bruce and Bessant, 2002) discussing how design can significantly add value to the organization's product and service offerings. This paper looks at the impact of two successful TCS (Teaching Company Scheme) programmes that were conducted within Haley Sharpe Associates, a leading UK Interior Design consultancy in 1993, supervised by one of the paper's authors. As a result of TCS, design productivity within the company has doubled and new in-house design services have been established.