gebhart/patrepeval huggingface dataset:
Virtual Reality Mobile Application Testing in a 5G Testbed (2019)

This paper describes an experiment for a Virtual Reality (VR) mobile application testing in a 5G testbed. The application in its current state streams high quality multimedia content from a Cloud server creating an immersive experience for the end user. While loading the 3D environment from the Cloud server, high LTE network latency and high power consumption are observed. In this context, utilizing Multi-Access Edge Computing (MEC) and 5G technologies can bring many benefits to the VR application. An experiment has been designed to test the application in a 5G testbed and metrics in terms of reliability, power consumption, network resources consumption, and user experience are noted. The paper reports the experiment, testbed tools, results obtained, and upgrades performed to VR application.
Tin nanowire field effect transistor (2012)

Semimetal tin nanowires of sufficiently small diameters become semiconductors. Bandgap engineering based on this effect allows for the design of a confinement modulated gap field-effect transistor in which the need for doping in the source, channel or drain is eliminated. Functionality of a dopant-free, single-material field effect transistor is demonstrated through ab initio simulations. Drain-source current-voltage characteristic of the confinement modulated gap transistor shows that the subthreshold slope and the on/off ratio are 73 mV/dec and up to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> at V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> =400 mV, respectively.
Financiamento da educação e políticas públicas: o Fundef e a política de descentralização (2001)

Este artigo aborda a discussão dos principais impactos do Fundef na política educacional atual. Através de uma abordagem particular sobre os impactos no sistema educativo público e nas relações intergovernamentais no Brasil, o artigo visa polemizar as possibilidades e os cenários criados pelo Fundo. As divergências com a posição oficial do MEC são remarcadas pelo autor.
Synthesis and Biochemical Evaluation of a Series of Aminoflavones as Potential Inhibitors of Protein-Tyrosine Kinases p56lck, EGFr, and p60v-src (1994)

A series of nitroflavones, 8a-p, and their corresponding aminoflavone hydrochloride salts, 10a-p, was synthesized. The preparation of nitroflavones 8b-i,o,p began with commercially available o-hydroxyacetophenones 2b-f which were converted to o-hydroxynitroacetophenones 3a-h via a variety of nitration methods, followed by condensation with nitrobenzoyl chlorides and cyclization under acidic condition. The nitroflavones 8aj-n were prepared by nitration of the corresponding flavones 7a-e. These new compounds were evaluated for their abilities to inhibit the in vitro protein-tyrosine kinase activities of p56lck, EGFr, and p60v-src, and all of the active compounds were amino-substituted flavones. None of the nitroflavones inhibited the enzymes. The most active substance in this series against p56lck was compound 10j, which had an IC50 of 18 microM. When tested versus EGFr, compounds 10a,m displayed IC50's of 8.7 and 7.8 microM, respectively. Against p60v-src, 10a,m showed IC50 values of 28.8 and 38.4 microM, respectively.
Surface Irrigation: Theory and Practice (1987)

Surface irrigation :theory and practice , Surface irrigation :theory and practice , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
EFFECT OF ANTIMITOTIC AGENTS ON INTRACELLULAR REOVIRUS ANTIGEN. (1964)

Summary Intracellular reovirus antigen localizes in the area occupied by the achromatic figure of mitotic cells. In untreated interphase cells, viral antigen forms a filamentous, intracytoplasmic reticulum, but in the presence of certain spindle poisons it consolidates into clumps. The specificity of this latter phenomenon was investigated in this study. The results obtained are as follows. 1.Six of eight spindle poisons tested were found to have a disruptive effect on the intracellular organization of reovirus antigen; antimitotic agents that have not been reported to disrupt the mitotic spindle had no effect. 2.Antigen of all three reovirus types formed filaments in interphase cells, localized with the mitotic apparatus, and responded similarly to the same concentrations of spindle poisons. The concentration of spindle poison required to clump type 1 reovirus antigen (the only type tested) varied in different cells. 3.The effect of those spindle poisons tested was found to be reversible. 4.Colchicine had no effect on the development of infectious virus and did not reduce the infectivity of infectious culture fluids. These results indicate that spindle poisons affect intracellular reovirus antigen indirectly by their action on the spindle or on a closely related organelle of similar physicochemical structure.
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice (2004)

Mutations in MECP2 are the cause of Rett syndrome (RTT) in humans, a neurodevelopmental disorder that affects mainly girls. MeCP2 is a protein that binds CpG dinucleotides and is thought to act as a global transcriptional repressor. It is highly expressed in neurons, but not in glia, of the postnatal brain. The timing of MeCP2 activation correlates with the maturation of the central nervous system, and recent reports suggest that MeCP2 may be involved in the formation of synaptic contacts and may function in activity-dependent neuronal gene expression. Deletion or targeted mutation of Mecp2 in mice leads to a Rett-like phenotype. Selective mutation of Mecp2 in postnatal neurons leads to a similar, although delayed, phenotype, suggesting that MeCP2 plays a role in postmitotic neurons. Here we test the hypothesis that the symptoms of RTT are exclusively caused by a neuronal MeCP2 deficiency by placing Mecp2 expression under the control of a neuron-specific promoter. Expression of the Mecp2 transgene in postmitotic neurons resulted in symptoms of severe motor dysfunction. Transgene expression in Mecp2 mutant mice, however, rescued the RTT phenotype.
The Recovery of Protein from Potato Juice Waste Water by Foam Separation (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe Recovery of Protein from Potato Juice Waste Water by Foam SeparationD. C. Weijenberg, J. J. Mulder, A. A. H. Drinkenburg, and S. StemerdingCite this: Ind. Eng. Chem. Process Des. Dev. 1978, 17, 2, 209–213Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/i260066a016https://doi.org/10.1021/i260066a016research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children (2016)

This study showed a correlation between obesity, IR, and biomarkers associated with NASH in pediatrics patients from West Virginia, with obese with IR patients showing the strongest correlation. These findings support the clinical application of these serum biomarkers as a less invasive method for early detection of NASH and hepatic fibrosis.
P2B-13 Speckle Statistics in Adaptive Beamforming (2007)

We have examined the statistics of the speckle patterns in images formed using delay-and-sum and minimum variance beamforming. We show how the estimate of the spatial covariance matrix used in the latter beam- former affects the speckle patterns. By using purely spatial averaging in the estimate the speckle statistics are quite different from delay-and-sum: Areas that are apparently homogeneous in delay-and-sum images appear as a collection of point scatterers in the minimum variance images, reducing the overall brightness of the speckle. We show that temporal averaging reduces this effect without compromising the improved spatial resolution offered by the minimum variance beamformer. Results from both simulations and experimental RF data are shown.
Purification and characterization of a cathepsin D protease from bovine chromaffin granules (1992)

Purification and potential tachykinin and enkephalin precursor cleaving enzymes from bovine chromaffin granules was undertaken using as substrates the model precursors 35S-(Met)-beta-preprotachykinin [35S-(Met)-beta-PPT] and 35S-(Met)-preproenkephalin [35S-(Met)-PPE]. Purification by concanavalin A-Sepharose, Sephacryl S200, and chromatofocusing resulted in a chromaffin granule aspartyl protease (CGAP) that preferred the tachykinin over the enkephalin precursor. CGAP was composed of 47-, 30-, and 16.5-kDa polypeptides migrating as a single band in a nondenaturing electrophoretic gel system, and coeluting with an apparent molecular mass of 45-55 kDa by size-exclusion chromatography. These results suggest that two forms exist: a single 47-kDa polypeptide and a complex of 30 + 16.5-kDa-associated subunits. CGAP was optimally active at pH 5.0-5.5, indicating that it would be active within the acidic intragranular environment. Cleavage at basic residues was suggested by HPLC and HVE identification of 35S-(Met)-NKA-Gly-Lys as the major acid-soluble product generated from 35S-(Met)-beta-PPT. Neuropeptide K was cleaved at a Lys-Arg basic residue site, as determined by identification of proteolytic products by microsequencing and amino acid composition analyses. Structural studies showed that the three CGAP polypeptides were similar to bovine cathepsin D in NH2-terminal sequences and amino acid compositions, indicating that CGAP appears to be a cathepsin D-related protease or cathepsin D itself. The 47- and 16.5-kDa polypeptides of CGAP possessed identical NH2-terminal sequences, suggesting that the 16.5-kDa polypeptide may be derived from the 47-kDa form by proteolysis.(ABSTRACT TRUNCATED AT 250 WORDS)
Synthesis of 9-substituted carbacyclin analogs (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 9-substituted carbacyclin analogsPaul A. Aristoff, Paul D. Johnson, and Allen W. HarrisonCite this: J. Org. Chem. 1983, 48, 26, 5341–5348Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/jo00174a035https://doi.org/10.1021/jo00174a035research-articleACS PublicationsRequest reuse permissionsArticle Views226Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
1,2,3-triazolo[1.5-a]quinazolines: synthesis, benzodiazepine receptor binding and theoretical calculations. (1996)

This paper reports the synthesis of 3-substituted-1,2,3-triazolo[1,5-a]quinazolin-5-ones prepared by 1,3-dipolar cycloaddition reaction of 2-azidobenzoic acid to methylenic compounds activated by a cyano group. The new derivatives were submitted to benzodiazepine receptor binding assays: the results indicated an interesting receptorial affinity of the 1,2,3-triazolo[1,5-a]quinazoline ring. On the basis of the biological results, theoretical calculations were performed, which suggested useful structural modifications.
A taxonomy-based comparison of several distributed shared memory systems (1990)

Two possible modes of Input/Output (I/O)are "sequential" and "random-access", and there is an extremely strong conceptual link between I/O and communication. Sequential communication, typified in the I/O setting by magnetic tape, is typified in the communication setting by a stream , e.g., a UNIX 1 pipe. Random-access communication, typified in the I/O setting by a drum or disk device, is typified in the communication setting by shared memory . In this paper, we study and survey the extension of the random-access model to distributed computer systems. A Distributed Shared Memory (DSM) is a memory area shared by processes running on computers connected by a network. DSM provides direct system support of the shared memory programming model. When assisted by hardware, it can also provide a low-overhead interprocess communication (IPC) mechanism to software. Shared pages are migrated on demand between the hosts. Since computer network latency is typically much larger than that of a shared bus, caching in DSM is necessary for performance. We use caching and issues such as address space structure and page replacement schemes to define a taxonomy. Based on the taxonomy we examine three DSM efforts in detail, namely: IVY, Clouds and MemNet.
Biological regeneration of manganese (IV) and iron (III) for anaerobic metal oxide-mediated removal of pharmaceuticals from water (2018)

Applying manganese(IV)- or iron(III)-(hydr)oxides to remove pharmaceuticals from water could be attractive, due to the capacity of these metal oxides to remove pharmaceuticals and be regenerated. As pharmaceutical removal under anaerobic conditions is foreseen, Mn(IV) or Fe(III) regeneration under anaerobic conditions, or with minimum oxygen dosage, is preferred. In this study, batch experiments are performed to investigate (1) Mn(IV) and Fe(III) regeneration from Mn(II) and Fe(II); (2) the pharmaceutical removal during biological Mn(IV) and Fe(III) regeneration; and (3) anaerobic abiotic pharmaceutical removal with different Mn(IV) or Fe(III) species. Results show that biological re-oxidation of reduced Mn(II) to Mn(IV) occurs under oxygen-limiting conditions. Biological re-oxidation of Fe(II) to Fe(III) is obtained with nitrate under anaerobic conditions. Both bio-regenerated Mn(IV)-oxides and Fe(III)-hydroxides are amorphous. The pharmaceutical removal is insignificant by Mn(II)- or Fe(II)-oxidizing bacteria during regeneration. Finally, pharmaceutical removal is investigated with various Mn(IV) and Fe(III) sources. Anaerobic abiotic removal using Mn(IV) produced from drinking water treatment plants results in 23% metoprolol and 44% propranolol removal, similar to chemically synthesized Mn(IV). In contrast, Fe(III) from drinking water treatment plants outperformed chemically or biologically synthesized Fe(III); Fe (III) from drinking water treatment can remove 31-43% of propranolol via anaerobic abiotic process. In addition, one of the Fe(III)-based sorbents tested, FerroSorp<sup>®</sup>RW, can also remove propranolol (20-25%). Biological regeneration of Mn(IV) and Fe(III) from the reduced species Mn(II) and Fe(II) could be more effective in terms of cost and treatment efficiency.
Time Resolved Native Ion-Mobility Mass Spectrometry to Monitor Dynamics of IgG4 Fab Arm Exchange and “Bispecific” Monoclonal Antibody Formation (2013)

Monoclonal antibodies (mAbs) and derivatives such as antibody-drug conjugates (ADC) and bispecific antibodies (bsAb), are the fastest growing class of human therapeutics. Most of the therapeutic antibodies currently on the market and in clinical trials are chimeric, humanized, and human immunoglobulin G1 (IgG1). An increasing number of IgG2s and IgG4s that have distinct structural and functional properties are also investigated to develop products that lack or have diminished antibody effector functions compared to IgG1. Importantly, wild type IgG4 has been shown to form half molecules (one heavy chain and one light chain) that lack interheavy chain disulfide bonds and form intrachain disulfide bonds. Moreover, IgG4 undergoes a process of Fab-arm exchange (FAE) in which the heavy chains of antibodies of different specificities can dissociate and recombine in bispecific antibodies both in vitro and in vivo. Here, native mass spectrometry (MS) and time-resolved traveling wave ion mobility MS (TWIM-MS) were used for the first time for online monitoring of FAE and bsAb formation using Hz6F4-2v3 and natalizumab, two humanized IgG4s which bind to human Junctional Adhesion Molecule-A (JAM-A) and alpha4 integrin, respectively. In addition, native MS analysis of bsAb/JAM-A immune complexes revealed that bsAb can bind up to two antigen molecules, confirming that the Hz6F4 family preferentially binds dimeric JAM-A. Our results illustrate how IM-MS can rapidly assess bsAb structural heterogeneity and be easily implemented into MS workflows for bsAb production follow up and bsAb/antigen complex characterization. Altogether, these results provide new MS-based methodologies for in-depth FAE and bsAb formation monitoring. Native MS and IM-MS will play an increasing role in next generation biopharmaceutical product characterization like bsAbs, antibody mixtures, and antibody-drug conjugates (ADC) as well as for biosimilar and biobetter antibodies.
Cancer prevention by natural carotenoids (1997)

Epidemiological investigations have shown that cancer risk is inversely related to the consumption of green and yellow vegetables and fruits. Since beta-carotene is present in abundance in these vegetables and fruits, it has been investigated extensively as a possible cancer preventive agent. However, various carotenoids that coexist with beta-carotene in vegetables and fruits also have anticarcinogenic activity. Some of them, such as alpha-carotene, showed higher potency than beta-carotene in suppressing experimental carcinogenesis. Thus, we have carried out more extensive studies on cancer-preventive activities of natural carotenoids, which found that lycopene and lutein had potent anticarcinogenic activity. In the present study, the cancer-preventive activity of phytoene was also confirmed biotechnologically when mammalian cells producing phytoene were resistant to H-ras-induced cell transformation. Further studies on various natural carotenoids besides beta-carotene should be continued to obtain more information about the potential of natural carotenoids in the field of cancer prevention.
A Two-Level Automatic Help Desk Based on a New Statistical Approach (2008)

In this paper we propose a two-level automatic help desk based on a new statistical approach. The proposed system is used to simulate a technical support centre as a help desk for a Web site which is used in order to provide the visitors with designing and printing services. In contrary to the existing help desks which employ some expert people to make a technical support group, we propose a help desk capable of answering the preliminary questions received from the user side at the first level automatically. If the user's problem can not be solved at the first level, it can be followed by the user using a ticket at the second level which is supported by the real experts. This statistical approach can be used consistently in different domains and problem spaces without any need for a new design, regarding the new domain.
How to maximize the aspect ratio of clay nanoplatelets (2012)

Melt-synthesis yielded lithium-fluorohectorites (Li-hect(x)) with variable layer charge (x = 0.4, 0.6, 0.8, 1.0). Counterintuitively, both tactoid diameter and intracrystalline reactivity increased concomitantly with increasing layer charge. This way hectorites with very large diameters were obtained (d(50%) = 48 μm) that nevertheless still spontaneously delaminate when immersed into water and nano-platelets with huge aspect ratios (>10 000) are formed. Melt-synthesis of Li-hect(x) has been performed in an open glassy carbon crucible allowing for easy scaling to batches of 500 g. These unprecedented huge aspect ratio fillers promise great potential for flame retardants and barrier applications.
Specific sequences in native DNA that arrest synthesis by DNA polymerase alpha. (1982)

The effect of the DNA sequence of a template on the progress of DNA polymerase alpha was determined at the resolution of single nucleotides by using single-stranded, circular phi X174 DNA as a template and unique phi X 174 ONA fragments terminally labeled at their 3'-ends as primers. Therefore, the amount of radioactivity observed was always proportional to the number and not the length of nascent DNA chains. Extension of a primer by alpha-polymerase revealed that 3'-ends of nascent DNA chains accumulated at specific arrest sites consisting of GC-rich sequences of 1-8 bases distributed nonuniformly along the template with intervening sequences of 0-140 bases. The precise location and composition of these sites were determined by DNA sequencing methods, but a consensus sequence was not detected. However, the same pattern of arrest sites recognized by DNA polymerase alpha from CV-1 cells also arrested alpha-polymerase from HeLa cells, calf thymus tissue, and phage T4 DNA polymerase. An exception was DNA polymerase I from Escherichia coli which was insensitive to arrest signals. Analysis of recombinant DNA templates containing phi X174 DNA inserted into M13 DNA revealed that arrest sites were defined exclusively by those sequences within 24 bases upstream and 140 bases downstream of the arrest point; long range interactions between template sequences were not involved. One of the strongest arrest sites was located in the first two nucleotides at the base of the stem on the primer-proximal side of a stable hairpin structure, suggesting that such structures arrest the polymerase. However, only 28% of all arrest site nucleotides were found in this position; the rest were up to 25 bases upstream from any computer-predicted hairpin. Therefore, all arrest sites cannot be defined by secondary structure alone, although proximity to secondary structures may amplify normal variations in the rate of DNA elongation caused by primary sequences.
An object-oriented approach to software development for parallel processing systems (2002)

An object-oriented approach to software development for parallel processing systems is presented. This approach is based on a computation model which incorporates the functional paradigm in the object-oriented paradigm and allows exploitation of massive parallelism without sacrificing the effectiveness of the object-oriented paradigm. The issues related to the development processes are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>