gebhart/patrepeval huggingface dataset:
T-Regulatory Cells Confer Increased Myelination and Stem Cell Activity after Stroke-Induced White Matter Injury (2019)

Stroke-induced hypoxia causes oligodendrocyte death due to inflammation, lack of oxygen and exacerbation of cell death. Bone marrow-derived stem cells (BMSCs) possess an endogenous population of T-regulatory cells (T<sub>regs</sub>) which reduce secretion of pro-inflammatory cytokines that lead to secondary cell death. Here, we hypothesize that oligodendrocyte progenitor cells (OPCs) cultured with BMSCs containing their native T<sub>reg</sub> population show greater cell viability, less pro-inflammatory cytokine secretion and greater myelin production after exposure to oxygen-glucose deprivation and reoxygenation (OGD/R) than OPCs cultured without T<sub>regs</sub>. OPCs were cultured and then exposed to OGD/R. BMSCs with or without T<sub>regs</sub> were added to the co-culture immediately after ischemia. The T<sub>regs</sub> were depleted by running the BMSCs through a column containing a magnetic substrate. Fibroblast growth factor beta (FGF-β) and interleukin 6 (IL-6) ELISAs determined BMSC activity levels. Immunohistochemistry assessed OPC differentiation. OPCs cultured with BMSCs containing their endogenous T<sub>regs</sub> showed increased myelin production compared to the BMSCs with depleted T<sub>regs</sub>. IL-6 and FGF-β were increased in the group cultured with T<sub>regs</sub>. Collectively, these results suggest that BMSCs containing T<sub>regs</sub> are more therapeutically active, and that T<sub>regs</sub> have beneficial effects on OPCs subjected to ischemia. T<sub>regs</sub> play an important role in stem cell therapy and can potentially treat white matter injury post-stroke.
The Effects of Non-Controllable Factors in Efficiency Evaluation of Turkish Coal Enterprises (2007)

In this study, which aims to examine the effects of non-controllable factors as well as input parameters on the efficiency performances of Turkish Coal Mine Enterprises, eight enterprises within Turkish Coal Enterprises (TCE) were examined. In order to keep the study as up-to-date as possible, data from the latest year (2005) was examined. For each enterprise, the outputs consisted of the amount of the production sold and the total income gained in the corresponding year; the controllable inputs consisted of investment expenditure, overburden stripping and number of staff; and non-controllable inputs consisted of total reserve and low heat values. In order to measure the effects of non-controllable inputs on enterprise efficiency, three-stage modified data envelopment analysis (DEA) model was employed. In the first stage, information concerning the efficiency of the enterprises was gained by using only the controllable inputs and outputs. In the second stage, the effects of non-controllable inputs on controllable inputs in inefficient enterprises were examined. Lastly in the third stage, the new efficiency values were calculated by means of DEA where controllable inputs and outputs modified according to non-controllable inputs were used. Considering the non-controllable inputs as a result of the analyses conducted with three-stage DEA model, it was determined that the average efficiency value of Turkish Coal Enterprises increased from 87.5% to 92.3%.
Fixed point algorithm for bit rate optimal equalization in multicarrier systems (1999)

We present a fixed point algorithm for bit rate optimal time domain equalization in multicarrier systems. The algorithm outperforms standard MMSE equalizers in capacity measure. Moreover, it adaptively estimates the optimal signal delay which was an exhaustive search problem in MMSE equalizers. We discuss the convergence properties and demonstrate the performance of the algorithm on a twisted pair copper wire loop with additive non-white noise.
The Static Theory of Finite Elasticity (1970)

A review of the equilibrium theory of finite deformations of elastic solids and its applications, with special emphasis on approximate methods of solution of problems.
Acid‐Catalyzed [3,3] Sigmatropic Rearrangement of <i>N</i>‐Cbz‐Diaryl Hydrazide for the Synthesis of Mono‐<i>N</i>‐Cbz‐1,1′‐biaryl‐2,2′‐diamine (2010)

Abstract N ‐Cbz‐Diaryl hydrazides undergo acid‐catalyzed [3,3] sigmatropic rearrangement to afford N ‐Cbz‐1,1′‐biaryl‐2,2′‐diamines. The resultant products can be versatile synthetic platforms for a wide variety of C 2 ‐ and/or nonsymmetric axially chiral ligands and organocatalysts.
Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether. (2005)

From all the studies performed, it can be concluded that these micellar systems can be used for the safe and effective delivery of insoluble bioactive.
Dynamic physiological partitioning on a shared-nothing database cluster (2015)

Traditional database management systems (DBMSs) running on powerful single-node servers are usually over-provisioned for most of their daily workloads and, because they do not show good-enough energy proportionality, waste a lot of energy while underutilized. A cluster of small (wimpy) servers, where its size can be dynamically adjusted to the current workload, offers better energy characteristics for those workloads. Yet, data migration, necessary to balance utilization among the nodes, is a non-trivial and time-consuming task that may consume the energy saved. For this reason, a sophisticated and easy to adjust partitioning scheme fostering dynamic reorganization is needed. In this paper, we adapt a technique originally created for SMP systems, called physiological partitioning, to distribute data among nodes that allows to easily repartition data without interrupting transactions. We dynamically partition DB tables based on the nodes' utilization and given energy constraints and compare our approach with physical partitioning and logical partitioning methods. To quantify possible energy saving and its conceivable drawback on query runtimes, we evaluate our implementation on an experimental cluster and compare the results w.r.t. performance and energy consumption. Depending on the workload, we can substantially save energy without sacrificing too much performance.
Accurate, scalable and integrative haplotype estimation (2019)

The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing datasets. It notably exhibits sub-linear running times with sample size, provides highly accurate haplotypes and allows integrating external phasing information such as large reference panels of haplotypes, collections of pre-phased variants and long sequencing reads. We provide SHAPEIT4 in an open source format and demonstrate its performance in terms of accuracy and running times on two gold standard datasets: the UK Biobank data and the Genome In A Bottle.
Interoperability for Smart Home Environment Using Web Services (2008)

Recent advances in computing and communication technologies paved the growth for applications and devices in smart home environment. A typical smart home is highly characterized by heterogeneity elements that need to perform joint execution of tasks in an efficient manner. Although there are huge growth of services, applications and devices in smart home environment, the interoperability elements still seems ambiguous. Being a distributed architecture, smart home environment needs certain degree of interoperability to manage sub-systems comprising of different platforms. Generally, these sub-systems are developed in isolation and consist of different operating system and tier of services. There is need for a cross-platform interoperability that could make the sub-systems ‘talk ’ each other and operate in an interoperable fashion within smart home environment. Web Services seems to be the emerging technology that could lead the way in providing greater interoperability. In this paper we describe the potential of Web Services technology using Simple Object Access Protocol (SOAP) in addressing the interoperability requirements for smart home environment. The SOAP protocol provides data exchange mechanism as well as optimized performance for interoperation among sub-systems residing in smart home environment. The proposed system performance is evaluated to demonstrate a complete, bi-directional realtime management of sub-systems in smart home environment. 1.
Retinol-Binding Protein-Deficient Mice:  Biochemical Basis for Impaired Vision (2002)

We reported previously that mice lacking plasma retinol-binding protein (RBP) are phenotypically normal except that they display impaired vision at the time of weaning. This visual defect is associated with greatly diminished eyecup levels of retinaldehyde and is reversible if the mutants are maintained for several months on a vitamin A-sufficient diet. Here we provide a biochemical basis for the visual phenotype of RBP-deficient mice. This phenotype does not result from inadequate milk total retinol levels since these are not different for RBP-deficient and wild-type mice. The eye, unlike all other tissues that have been examined, takes up dietary retinol very poorly. Moreover, compared to other tissues, the eye displays a strong preference for retinol uptake when retinol is delivered bound to RBP. The poor uptake of dietary retinol by the eye coupled with its marked ability to take up retinol from RBP, we propose, provides a basis for the impaired vision observed in weanling RBP-deficient mice. Further study of the mutants suggests that the impaired vision is reversible because the eyes of mutant mice slowly acquire sufficient retinol from the low levels of retinol present in their circulation either bound to albumin or present in lipoprotein fractions. Thus, the eye is unlike other tissues in the body in that it shows a very marked preference for acquiring retinol needed to support vision from the retinol-RBP complex and is unable to meet adequately its retinol need through uptake of recently absorbed dietary retinol. This provides an explanation for the impaired vision phenotype of RBP-deficient mice.
High‐performance V‐band monolithic quadruple sub‐harmonic mixer with anti‐parallel diode pair (2004)

Abstract A high‐performance V‐band quadruple subharmonic mixer monolithic circuit is fabricated using the millimeter‐wave monolithic integrated circuit (MIMIC) process. Due to the superior features of the anti‐parallel diode pair (APDP) and the utilization of a quarter of fundamental frequency, the proposed subharmonic mixer shows good conversion‐gain and isolation characteristics. Maximum conversion gain of 0.8 dB at an LO frequency of 14.5 GHz and an RF frequency of 60.4 GHz is measured. Both LO‐to‐RF and LO‐to‐IF isolations are higher than 50 dB in the operation mode. © 2004 Wiley Periodicals, Inc. Microwave Opt Technol Lett 40: 349–352, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11378
A 3D-Printed Oxygen Control Insert for a 24-Well Plate (2015)

3D printing has emerged as a method for directly printing complete microfluidic devices, although printing materials have been limited to oxygen-impermeable materials. We demonstrate the addition of gas permeable PDMS (Polydimethylsiloxane) membranes to 3D-printed microfluidic devices as a means to enable oxygen control cell culture studies. The incorporation of a 3D-printed device and gas-permeable membranes was demonstrated on a 24-well oxygen control device for standard multiwell plates. The direct printing allows integrated distribution channels and device geometries not possible with traditional planar lithography. With this device, four different oxygen conditions were able to be controlled, and six wells were maintained under each oxygen condition. We demonstrate enhanced transcription of the gene VEGFA (vascular endothelial growth factor A) with decreasing oxygen levels in human lung adenocarcinoma cells. This is the first 3D-printed device incorporating gas permeable membranes to facilitate oxygen control in cell culture.
Calculation of Adequate Remodeling Period for The Improvement of Thermal Insulation Performance of External Walls in Deteriorated Apartments (2017)

Purpose: Under the purpose of presenting the adequate remodeling period for the improvement of thermal insulation performance of external walls in deteriorated buildings, the change in external wall and residential environment problem(dew condensation) due to aged deterioration after the apartments were constructed in Korea were analyzed. Method: Temperature Difference Ratio Outside(TDRo) and Heat Flow Meter(HFM) were used as measurement methods to evaluate the thermal insulation performance of deteriorated buildings. For TDR evaluation, thermo-graphic camera was used to measure and analyze the surface temperature of external wall. Also, dew condensation evaluation was analyzed using the Temperature Difference Ratio Inside(TDRi). Result: As a result of analyzing thermal performance through TDRo, the first decline point of thermal insulation performance began after 14-16 years have passed since construction was completed, and after 20 years have passed the decline point of thermal insulation performance reappeared. As a result of analyzing U-value with HFM measurement method, the decline rate of external wall’s thermal insulation performance is lower than 2% in average at around 5 years after completion, and 8.7% in average at 10-15 years, and over 10.2% in average at 20 years.
A GUI based visualization tool for sequence networks (1998)

A Windows based graphical user interface (GUI) software tool to facilitate the teaching and learning of sequence networks is described in this paper. This software is written in Microsoft Visual Basic. The software provides a friendly and easy to use tool to aid the students in better visualizing the effects of the sequence diagram and sequence current in the fault study. This tool has three main modules: a user designed one-line diagram; displaying the corresponding positive-, negative-, and zero-sequence diagrams; and displaying the path of the current in each sequence diagram, according to the type and the location of the fault.
Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy. (1978)

Studies on the effect of thymosin on T-cell levels in vitro among normal persons and cancer patients show that, in general, T-cell levels increase after incubation with thymosin in populations with low initial T-cell levels while the levels decrease in populations with high initial T-cell levels. In patients with small cell carcinoma of the lung receiving intensive chemotherapy also randomized to receive thymosin at a dose of 60 mg/m2, thymosin at a dose of 20 mg/m2, or placebo twice weekly, increased survival occurred in patients receiving the thymosin dose of 60 mg/m2. The increase in survival was greatest in patients with low pretreatment T-cell and alpha2HS-glycoprotein levels. These observations suggest that the cancer patients most likely to benefit therapeutically from adjuvant treatment with thymosin are those with relatively low initial T-cell levels and other parameters of cellular immunity.
Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization. (1991)

Forty transitional cell carcinomas of the human urinary bladder (TCCs) were examined for numerical aberrations of chromosomes 1, 7, 9, and 11 by in situ hybridization using chromosome-specific probes. Our interphase cytogenetic study of 24 low-grade, noninvasive TCCs, which were near-diploid by flow cytometry, showed a numerical aberration for at least 1 of these chromosomes in 14 of these cases. Most strikingly, a monosomy for chromosome 9 was found in 9 of 24 low-grade TCCs. A trisomy for chromosomes 1, 7, and 11 was detected in 5, 2, and 1 case(s), respectively. In 1 case a monosomy for chromosome 1 was detected by in situ hybridization. Monosomy for chromosome 9 was the only detected numerical change in 5 low-grade TCC cases. Examination of 16 invasive TCCs showed extra copies for chromosomes 1 and 7 in 7 flow cytometrically diploid cases with numerical chromosome aberrations; also, loss of chromosome 9 was detected. In 5 invasive and 2 noninvasive aneuploid/tetraploid TCCs a profound imbalance between the different chromosomes was found. In 5 of these cases an evident underrepresentation of chromosome 9 in comparison to chromosomes 1, 7, and 11 was detected. This underrepresentation of chromosome 9 in diploid, as well as aneuploid, TCCs, and in some cases the constant ratio between this chromosome and the other chromosomes, may be explained by a process of tetraploidization. Therefore, loss of chromosome 9 may be one of the primary genetic events in TCC oncogenesis, with secondary events, such as tetraploidization, correlated to tumor progression. Our results show that in situ hybridization can be routinely used to study important cytogenetic changes which occur during the development of a malignant disease.
An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients (2002)

These data show that the DQ8 restricted gliadin peptide is immunogenic only in the intestinal mucosa of HLA-DQ8 positive coeliac patients in both native and deamidated forms.
Graphene-Antenna Sandwich Photodetector (2012)

Nanoscale antennas sandwiched between two graphene monolayers yield a photodetector that efficiently converts visible and near-infrared photons into electrons with an 800% enhancement of the photocurrent relative to the antennaless graphene device. The antenna contributes to the photocurrent in two ways: by the transfer of hot electrons generated in the antenna structure upon plasmon decay, as well as by direct plasmon-enhanced excitation of intrinsic graphene electrons due to the antenna near field. This results in a graphene-based photodetector achieving up to 20% internal quantum efficiency in the visible and near-infrared regions of the spectrum. This device can serve as a model for merging the light-harvesting characteristics of optical frequency antennas with the highly attractive transport properties of graphene in new optoelectronic devices.
Catalytic effect of phosphine on the deposition of phosphosilicate glass from tetraethoxysilane (1993)

The effect of phosphorous incorporation on the deposition rate of phosphosilicate glass from the reaction of PH3, O2, and tetraethoxysilane (TEOS) has been studied. The previously reported apparent catalytic effect of PH3 on the deposition rate of SiO2 has been reproduced in this study, but by utilizing a newly designed hot-walled low-pressure chemical vapor deposition (LPCVD) reactor, homo- and heterogeneous catalytic effects were separated. These results indicate that the source of the catalytic effect is purely homogeneous, possibly involving an oxidation product of PH3 reacting with TEOS. Results obtained in a cold-wall reactor suggest that PH3 and O2 serve to poison the surface decomposition reaction of TEOS to produce SiO2.
<i>N,N</i>′-Sulfuryldiimidazole (2010)

[7189-69-7] C6H6N4O2S (MW 198.23)







InChI = 1/C6H6N4O2S/c11-13(12,9-3-1-7-5-9)10-4-2-8-6-10/h1-6H



InChIKey = ZLKNPIVTWNMMMH-UHFFFAOYAJ



(reagent for the generation of imidazolylsulfonates which function as leaving groups in SN2 displacement reactions)



Physical Data: stable crystalline solid, mp 141 °C.



Preparative Method: can be prepared from the reaction of Imidazole and Sulfuryl Chloride in THF at ambient temperature.2



Purification: recrystallized from ethanol.
The collagenase activity of<i>Porphyromonas gingivalis</i>is due to Arg-gingipain (2003)

Degradation of type I collagen by Porphyromonas gingivalis was monitored by fluorogenic, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and growth assays. All three assays showed that inactivation of both the rgpA and rgpB genes was necessary to completely eliminate the capacity of P. gingivalis to cleave type I collagen. Leupeptin, an Arg-gingipain-specific protease inhibitor, almost completely inhibited collagen degradation by P. gingivalis cells whereas cathepsin B inhibitor II, a Lys-gingipain inhibitor, did not. A purified preparation of Arg-gingipains A and B hydrolyzed gelatin but did not cleave type I collagen, suggesting that the enzymes must be attached to the cell surface to exert collagenase activity. A number of substances used as adjuncts in periodontal therapy were also tested for their capacity to inhibit collagenase activity of P. gingivalis. Tetracycline, doxycycline, and chlorhexidine strongly inhibited collagenase activity.
Platform for Load Balancing and Throughput Enhancement with Cognitive Radio (2008)

The cognitive radio system consists of multiple wireless access systems that cover overlapping areas and cognitive terminals that use one or more of the wireless access systems simultaneously. In this paper, we describe the system architecture of a platform for load balancing and throughput enhancement with cognitive radio system. In our platform, each terminal, which can access multiple radio systems, operates with a single local IP address. Based on our platform, we have developed both simulator and testbed system. Through the simulation of and the testing of a testbed system, we prove that systems load balance was achieved between WiMAX and wireless LAN, and total user throughput was increased with the proposed platform. Moreover, load balance to satisfy both real time service and best effort service. These results demonstrate the platform described in the paper can achieve a convergence with plural wireless systems.
Thermal mapping of transistors with a laser scanner (1976)

An active near-infrared laser scanner has been used to electronically map the temperature variations over the active regions of silicon interdigitated UHF transistors operating in the hot-spot regime. The principle makes use of the increase in electron-hole pair generation by the absorbed laser light with increasing temperature. The regions of enhanced photoresponse are displayed on a cathode-ray-tube display screen. Extensions to other devices and operating conditions, other than those which result in hot-spot operation, are suggested.
Molecular dynamics simulation of shell-symmetric Pd nanoclusters (2005)

The melting behaviour of Palladium (Pd) isolated shell-symmetric cubooctahedron and icosahedron nanoclusters, both consisting of 309 atoms, were simulated by Molecular Dynamics (MD) simulation, using the Sutton-Chen many-body potential (SC) for the interaction between the Pd atoms. The thermal, structural and dynamic properties were calculated for the Pd nanoclusters along the heating process. The cubooctahedron nanocluster melts around 1040 K, much lower than the melting point of bulk Pd system (1828.05 K). The icosahedron nanocluster melts around 1070 K. Furthermore, structural and dynamic evidence is found for the pre-melting of the nanoclusters. The outer two shells of the shell-symmetric nanocluster melt prior to their homogeneous melting of the whole nanoclusters.
A yield centric statistical design method for optimization of the SRAM active column (2009)

For robust design of SRAM memories, it is not sufficient to guarantee good statistical margins on the SRAM cell parameters. The sense amplifier needs sufficient input signal before it can reliably sense the data, while the SRAM cell requires sufficient time to develop that input signal. This paper presents a new statistical method that allows optimization of the access time of an SRAM memory, while guaranteeing a yield target set by the designer. Using this method, the access time of a high performance advanced CMOS SRAM has been improved 6%, while simultaneously reducing the sense amplifier size.