gebhart/patrepeval huggingface dataset:
Soluble‐E‐cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers (2013)

Recent literature suggests that sEcad exerts pro-oncogenic effects, possibly acting as a ligand for the human epidermal growth factor family. Here we show that sEcad is a novel candidate protein for drug targeting since it is increased in human and mouse HER2-positive (HER2+) breast tumors, MMTV-PyMT bodily fluids and human cell culture systems. Mechanistically, we show that endogenous sEcad, and to a lesser extent membrane-bound E-cadherin, associates with HER1, HER2, and HER3 in human and MMTV-PyMT mouse HER2+ tumors and with HER1 in triple negative breast cancer (TNBC) specimens. Furthermore, addition of exogenous recombinant human E-cadherin/Fc chimeric protein (rhEcad/Fc; sEcad) to HER2+ MCF-7, SKBR3, and HER2-negative MDA-MB-231 TNBC cells, resulted in sEcad-HER receptor family interactions, activation of HER1-4 and downstream pro-survival signaling, including the MAPK-PI3K/Akt/mTOR pathways and IAP family members. Lastly, we demonstrate that sEcad exerts pro-oncogenic effects via HER signaling, and acts additively with the HER ligand EGF to promote HER2+ breast cancer proliferation and migration, as well as TNBC invasion. Because sEcad associates and activates many of the oncogenic pathways that tumors utilize for growth and survival and serum levels in patients correlates with clinical response, suggests that targeted therapy against sEcad in combination with other therapies may potentially offer a novel therapeutic strategy for the treatment of breast cancers.
Selective decontamination of the digestive tract and oropharynx (2016)

Current evidence suggests that selective decontamination reduces mortality without increasing antibiotic resistances; this will be tested again in two huge international trials.
A study on integrating IoT Applications with Blockchain (2019)

Every industrial sector has started analysing the ways of utilizing the advancements in cyber physical technologies in their operations. Internet of Things has emerged as a new way of connecting the physical world to the cyber world to obtain tremendous amount of information about the physical world and make it available in the Internet for advanced analytics and business decision making. Thus, IoT promises huge results in terms of revenue, safety, monitoring and management in every business unit of an Enterprise. Block chain has emerged as a key technology in storing data in distributed ledgers which is not possible or extremely difficult to modify or damage. Wherever data security is significant and ensuring the integrity of data is challenging, we may apply Block chain to resolve the issues. This paper analyses the suitability of using Block chain in IoT ecosystems in the first part. The consequences of integrating Block chain with IoT and the opportunities and challenges in this process are discussed in the next part of the paper with use cases. Based on the contemporary challenges and maturity of the technology, this paper concludes the most appropriate set of applications on which Block chain and IoT can function together and it proposes a way of making the best possible outcomes from both the domains.
Effect of seabuckthorn (<i>Hippophae rhamnoides</i> ssp. <i>sinensis</i>) leaf extract on the swimming endurance and exhaustive exercise‐induced oxidative stress of rats (2011)

The findings suggest that SBT leaf aqueous extract supplements can enhance exercise capacity and protect against oxidative damage caused by exhaustive exercise in rats.
Synthesis and Characterization of Palladium(II) and Platinum(II) Complexes Containing Water-Soluble Hybrid Phosphine−Phosphonate Ligands (1996)

Water-soluble phosphonate-functionalized triaryl phosphine ligands Na(2)[Ph(2)P(4-C(6)H(4)PO(3))].1.5H(2)O (4a), Na(2)[Ph(2)P(3-C(6)H(4)PO(3))].2H(2)O (4b), and Na(2)[Ph(2)P(2-C(6)H(4)PO(3))].2H(2)O (4c), were prepared in 54-56% yields by the transesterification and hydrolysis of the appropriate phosphonic acid diethyl ester precursors. The solubilities of 4a-c in water are compared and the spectroscopic properties studied in detail. The crystal structure of Na(2)[Ph(2)P(4-C(6)H(4)PO(3))(H(2)O)(3)(CH(3)OH)].CH(3)OH (monoclinic, P2(1)/n, a = 6.4457(8) Å, b = 8.1226(8) Å, c = 46.351(3) Å, beta = 92.902(8) degrees, Z = 4) shows a dimeric association via two bridging water molecules and four sodium ions. Reaction of 4a with PtCl(2)(PPh(3))(2) in a biphasic H(2)O/CH(2)Cl(2) mixture gives cis- and trans-Na(4)[PtCl(2){Ph(2)P(4-C(6)H(4)PO(3))}(2)]. 3H(2)O. Palladium dichloride and 4a in H(2)O/benzene catalyzes the carbonylation of benzyl chloride to give phenylacetic acid (91%).
Impact of spectral inverter fiber length on four-wave mixing efficiency and signal distortion (1995)

We compare the performance of spectral inversion through four-wave mixing in a long (13.5 km) and a short (1.5 km) dispersion-shifted optical fiber, respectively. While the effectiveness of the long fiber is limited by nonlinear phenomena such as stimulated Brillouin scattering and cross-phase modulation, the effectiveness of the short fiber is limited only by the available power, since the critical power levels where the deleterious nonlinear phenomena occur increase when the fiber length decreases. With the requirement of negligible spectral deformation of the inverted signal, the shorter fiber gives 60% higher conversion efficiency and four times more converted optical power. Measured with 12-nm wavelength conversion from the signal to the inverted replica.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Single‐ and Multiple‐Dose Pharmacokinetics of Long‐acting Injectable Naltrexone (2006)

This study demonstrated that the long-acting naltrexone formulation was well tolerated, displayed predictable pharmacokinetics, and resulted in no meaningful drug accumulation upon multiple dosing. Intramuscular administration avoids first-pass metabolism and changes the exposure ratio of 6beta-naltrexol to naltrexone compared with oral administration. By providing continuous exposure to naltrexone for several weeks following IM injection, this long-acting naltrexone formulation may offer therapeutic benefit to those patients who experience difficulty adhering to the daily administration schedule necessitated by oral naltrexone therapy.
ChemInform Abstract: Synthesis of Fused Indole Derivatives Based on 1‐(2,6‐Dichlorophenyl)‐ 3‐dimethylaminomethyleneindolinone‐2. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Disruption of vascular endothelial homeostasis by tobacco smoke—impact on atherosclerosis (2003)

The World Health Organization (WHO) predicts that by 2020 tobacco will become the largest single health problem worldwide and will cause an estimated 8.4 million deaths annually (http://www5.who.int/tobacco/). Although the impact of smoking on human health is well defined from the medical point of view, surprisingly little is known about the mechanisms by which tobacco smoke mediates its disastrous effects. Here, we demonstrate that tobacco smoke dramatically changes vascular endothelial cell and tissue morphology, leading to a loss of endothelial barrier function within minutes. Long-term exposure of endothelial cells to tobacco smoke extracts induces necrosis that may trigger a pro-inflammatory status of the vessel wall. Pre-incubation of the extracts without cells for 6 h at 37 degrees C led to a complete loss of activity. Further, the endothelium could be rescued by changing to fresh medium even at times when the extracts had lost their activity. Finally, we show that N-acetyl cysteine and statins inhibit the adverse tobacco smoke effects.
Spiro oxazolidinedione aldose reductase inhibitors (1982)

Spiro oxazolidinediones (2) derived from five- and six-membered ring aralkyl ketones are potent aldose reductase inhibitors in vitro and in vivo. Their novel and general synthesis has been devised with alpha-hydroxyimidates (5) and 4-alkoxy-2-oxo-3-oxazolines (6) as key intermediates, since traditional synthetic routes through alpha-hydroxy amides (8) usually led to alpha, beta-unsaturated amides (9). Resolution with cinchonidine afforded optically active spiro oxazolidinediones. Optimum biological activity resided in (4S)-6-chlorospiro [4H-2,3-dihydrobenzopyran-4,5'-oxazolidine]-2',4'-dione (21) and its 6,8-dichloro congener (23).
Pluripotent Stem Cells: Current Understanding and Future Directions (2015)

Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features. Here, we provide a detailed overview of the family of pluripotent cell lines derived from early mouse and human embryos and compare them with induced pluripotent stem cells. Shared and distinct features of these cells are reported as additional hallmark of pluripotency, offering a comprehensive scenario of pluripotent stem cells.
Fast On-the-Fly Parametric Real-Time Model Checking (2006)

This paper presents a local algorithm for solving the universal parametric real-time model-checking problem. The problem may be phrased as follows: given a real-time system and temporal formula, both of which may contain parameters, and a constraint over the parameters, does every allowed parameter assignment ensure that the real-time system satisfies the formula? Our approach relies on translating these model-checking problems into predicate equation systems, and then using an efficient proof-search algorithm to solve these systems. Experimental data shows that our method substantially outperforms existing approaches for systems that contain errors, while exhibiting comparable behavior for systems that are correct. This fast error-detection capability of our technique makes it especially interesting for design approaches in which model checkers are used "early and often" to detect design errors in an ongoing manner.
On-line Determination of Particle Size and Density in the Nanometer Size Range (1995)

An on-line, semicontinuous method for the determination of size and effective density (g/cm3) of particles in the 3–50 nm size range was evaluated using laboratory test aerosols. The method, called double size spectrometry, sizes particles twice, first by electrical mobility, and then by aerodynamic behavior. The first measure gives the geometric diameter for spherical particles. The second measure depends on single particle density. The double size spectrometer uses a differential mobility analyzer and hypersonic impactor in series. The mobility analyzer outputs singly-charged particles of a uniform diameter that are resized by the impactor. The impactor flow is supersonic; the critical aerodynamic capture diameter is varied by adjusting the orifice-to-plate separation; and particle capture is measured on-line by an electrometer. Theoretically, the response is described by a particle Stokes number. Experiments with 10–40 nm particles of dioctylsebacate and a perfluorocarbon vacuum oil gave critical Stokes number for capture near 1. The measured density ratio was 1.9, compared with the bulk material density ratio of 2.0. Experiments with 3–14 nm spark generated silver and copper aerosols differed, with apparent aerosol densities lower than the bulk values by factors of 2.5–3.6.
The challenge of cross-language interoperability (2013)

Interfacing between languages is becoming more important
Reversible photoreductive deposition and oxidative dissolution of copper ions in titanium dioxide aqueous suspensions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible photoreductive deposition and oxidative dissolution of copper ions in titanium dioxide aqueous suspensionsNancy S. Foster, Richard D. Noble, and Carl A. KovalCite this: Environ. Sci. Technol. 1993, 27, 2, 350–356Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/es00039a016https://doi.org/10.1021/es00039a016research-articleACS PublicationsRequest reuse permissionsArticle Views703Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Seed development in ryegrass, and in red and white clover (1959)

Summary Studies were made of the rate of development of the seeds of perennial and Italian ryegrass, and of red and white clover. Three developmental phases can be recognised; the first a period of rapid growth and constant high moisture percentage, lasting about 10 days from pollination, during which viability is nil; a second phase of 10–14 days, when growth is slower and percentage moisture falls steadily, with sudden acquisition of viability; and a final phase of 3–7 days in which dry weight is constant but moisture decreases markedly. The effect of harvesting during these three phases is discussed, and mention is made of features useful in identifying the developmental stages.
An antenna switching based NOMA scheme for IEEE 802.15.4 concurrent transmission (2020)

This paper introduces a Non-Orthogonal Multiple Access (NOMA) scheme to support concurrent transmission of multiple IEEE 802.15.4 packets. Unlike collision avoidance Multiple Access Control (MAC), concurrent transmission supports Concurrent-MAC (C-MAC) where packet collision is allowed. The communication latency can be reduced by C-MAC because a user can transmit immediately without waiting for the completion of other users' transmission. The big challenge of concurrent transmission is that error free demodulation of multiple collided packets hardly can be achieved due to severe Multiple Access Interference (MAI). To improve the demodulation performance with MAI presented, we introduce an architecture with multiple switching antennas sharing a single analog transceiver to capture spatial character of different users. Successive Interference Cancellation (SIC) algorithm is designed to separate collided packets by utilizing the spatial character. Simulation shows that at least five users can transmit concurrently to the SIC receiver equipped with eight antennas without sacrificing Packet Error Rate.
Chromium Free Alternative Etching Treatment for Plating on ABS Resin Using TiO2 as Photocatalyst (2006)

ABS樹脂は, 家電部品や自動車などに応用され, プラスチックへのめっき材料として広汎に使用されている。一般的に, ABS樹脂は, 素材および析出金属問の密着性を得るために, H2SO4およびCrO3から成る強力な酸化剤によってエッチングする。近年, 環境汚染の規制は, WEEEやRoHS指令の文書に見られるように, 世界的に重要な関心事となっている。したがって, 有害物質を使用しない環境調和型エッチング技術が必要である。そこで, われわれは, クロム酸代替として光触媒である酸化チタンの使用に着目し, TiO2存在下で, UV照射を行うことにより, 有効な表面改質が可能であることを見いだした。本報ではABS樹脂中のブタジェン含有率を変化することにより, 密着強度の改善を検討した。その結果, ブタジェン含有率15～30%の範囲のABS樹脂で, 1.0kNm-1の密着強度が得られることがわかった。われわれはSEMおよびFE-TEM観察より, その密着性は粗れた樹脂表面なしで, ナノレベルのアンカー効果により得られることを確認した。
Effect of Adding Albumin to Solutions of Secretin on Pancreatic Volume and Bicarbonate Response (1981)

In six conscious dogs with gastric and pancreatic Thomas fistulas, we studied the pancreatic bicarbonate response to intravenous bolus injections of synthetic secretin dissolved either in 5 ml of 0.15 M NaCl alone or in the same amount of NaCl to which dog albumin had been added, to give a 0.1% solution. The pancreatic bicarbonate (micromol . 10 min-1) response to the four lowest doses of secretin (12.5, 25, 50, 100 ng . kg-1) used was significantly (p less than 0.05) higher when secretin was dissolved in NaCl plus albumin than in NaCl alone. The pancreatic response to higher doses of secretin (200, 400, 800, 1600 ng . kg-1) was not significantly altered by the addition of albumin. The D50 of secretin was about 2.6 times greater in the absence than in the presence of albumin. This study suggests that albumin should be added to dilute solutions of secretin to preserve biological activity.
A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer. (1993)

The poly(ADP-ribose) polymerase (PADPRP) gene (13q33-qter) depicts a two-allele (A/B) polymorphism. In the noncancer population, the frequency of the B allele is higher among blacks than among whites. Since the incidence of multiple myeloma and prostate and lung cancer is higher in the U.S. black population, we have analyzed the B-allele frequency in germ-line DNA to determine whether the PADPRP gene correlates with a polymorphic susceptibility to these diseases. For multiple myeloma and prostate cancer, an increased frequency of the B allele appeared to be striking only in black patients. In contrast, the distribution of the B allele in germ-line DNA did not differ among white patients with these diseases, when compared with the control group. An elevated B-allele frequency was also found in germ-line DNA in blacks with colon cancer. These observations suggest that the PADPRP polymorphism may provide a valid marker for a predisposition to these cancers in black individuals. To determine the genomic structure of the polymorphic PADPRP sequences, a 2.68-kb HindIII clone was isolated and sequenced from a chromosome 13-enriched library. Sequence analysis of this clone (A allele) revealed a close sequence similarity (91.8%) to PADPRP cDNA (1q42) and an absence of introns, suggesting that the gene on 13q exists as a processed pseudogene. A 193-bp conserved duplicated region within the A allele was identified as the source of the polymorphism. The nucleotide differences between the PADPRP gene on chromosome 13 and related PADPRP genes were exploited to develop oligonucleotides that can detect the difference between the A/B genotypes in a PCR. This PCR assay offers the opportunity for analyzing additional black cancer patients, to determine how the PADPRP processed pseudogene or an unidentified gene that cosegregates with the PADPRP gene might be involved with the development of malignancy.
Reactive-Distillation Process for Direct Hydration of Cyclohexene to Produce Cyclohexanol (2014)

Cyclohexanol is an important precursor in synthesizing intermediates of Nylons and also plasticizers. In this paper, a plantwide reactive-distillation process for the production of cyclohexanol by direct hydration of cyclohexene with water has been studied. Design with excess water is needed to economically increase conversion of cyclohexene to 99.9%. The optimal design of the proposed flowsheet also makes use of the natural liquid–liquid splitting of the binary cyclohexanol–water azeotrope. Realistic fresh cyclohexene feed with impurity of cyclohexane was also considered. This inert is designed to leave the system in the organic outlet stream of a decanter on top of the reactive-distillation column. The reboiler duty requirement of the proposed design flowsheet is compared with existing processes in open literature. It is found that significant energy savings can be realized by using this design.
Effect of electronic state of ions on the electrochemical properties of layered cathode materials LiNi1−2x Co x Mn x O2 (2008)

The cathode materials of the composition LiNi1 − 2x Co x Mn x O2 (x = 0.1, 0.2. 0.33) synthesized from the Ni, Co, Mn mixed hydroxides and LiOH by using mechanical activation method are studied. It is shown that all synthesized compounds have layered structure described by the space group R-3m. With the decreasing of the nickel content the cell volume and the degree of structure disordering decrease. According to XPS data, the electronic main state of d-ions at the prepared samples’ surfaces corresponds to Ni2+, Co3+, and Mn4+. An increase in the nickel content leads to the increase of the Ni2p 3/2 and Co2p 3/2 binding energy, which points to the change in the Me-O bond covalence. According to magnetic susceptibility measurements data, the nickel ions in LiNi0.6Co0.2Mn0.2O2 exist in the two oxidation states: Ni2+ and Ni3+. It is shown that this sample has the highest specific discharge capacity (∼170 mAh/g). The positions of redox peaks in the differential capacitance curves depend on the sample composition: with the increasing of nickel content they are shifted toward lower voltages.
Substituted Acrylonitriles in Heterocyclic Synthesis. The Reaction of α-Substituted β-(2-Furyl)-acrylonitriles with Some Active-Methylene Heterocycles (1985)

La reaction d'α-cyano-, d'α-benzoyl- et d'α-ethoxycarbonylfuranneacrylonitriles-2 avec des pyrazoline-2ones-5, thiazolidinedione-2,4 et thioxo-4 thiazolidone-2 conduit respectivement aux [furyl-2]-4 pyranno [2,3-c] pyrazolecarbonitriles-5, [furyl-2]-4 pyranno [2,3-d] thiazolecarbonitriles-5 et [furyl-2]-4 thiopyranno [2,3-d] thiazolecarbonitriles-5
SemEval-2007 task 14 (2007)

The "Affective Text" task focuses on the classification of emotions and valence (positive/negative polarity) in news headlines, and is meant as an exploration of the connection between emotions and lexical semantics. In this paper, we describe the data set used in the evaluation and the results obtained by the participating systems.
Single-walled carbon nanotube weak links in Kondo regime with zero-field splitting (2009)

We have investigated proximity-induced supercurrents in single-walled carbon nanotubes in the Kondo regime and compared them with supercurrents obtained on the same tube with Fabry-P\'erot resonances. Our data display a wide distribution of Kondo temperatures ${T}_{K}=1--14\text{ }\text{K}$, and the measured critical current ${I}_{\text{CM}}$ vs ${T}_{K}$ displays two distinct branches; these branches, distinguished by zero-field splitting of the normal-state Kondo conductance peak, differ by an order of magnitude at large values of ${T}_{K}$. Evidence for renormalization of Andreev levels in Kondo regime is also found.