gebhart/patrepeval huggingface dataset:
Gut commensal <i>Lactobacillus reuteri</i> 100‐23 stimulates an immunoregulatory response (2009)

Lactobacillus reuteri 100-23 is a bacterial commensal of the gastrointestinal tract of mice. Previous studies have shown that colonization of the murine gut by this strain stimulates small-bowel enterocytes to produce proinflammatory cytokines. This is associated with a mild, transitory inflammatory response 6 days after inoculation of formerly Lactobacillus-free animals. The inflammation subsides by 21 days after colonization, although lactobacilli continue to be present in the bowel. To determine the immunological mechanisms that underpin tolerance to bowel commensals, we investigated cytokine responses of dendritic cells and T cells after exposure to cells of L. reuteri 100-23. Interleukin-10 (IL-10), IL-2 and transforming growth factor-beta (TGF-beta) concentrations in supernatants of cultured immune cells, as well as the results of proliferative assays of mesenteric lymph node (MLN) cells and quantification of Foxp3-positive cells in MLN and spleen, indicated that L. reuteri 100-23 stimulated the development of an increased number of regulatory T cells.
Body Mass Index, Migraine, Migraine Frequency and Migraine Features in Women (2008)

We evaluated the association of body mass index (BMI) with migraine and migraine specifics in a cross-sectional study of 63 467 women aged > or = 45 years, of whom 12,613 (19.9%) reported any history of migraine and 9195 had active migraine. Compared with women without migraine and a BMI < 23 kg/m(2), women with a BMI > or = 35 kg/m(2) had adjusted odds ratios (ORs) (95% confidence intervals) of 1.03 (0.95, 1.12) for any history of migraine. Findings were similar for active migraineurs. Women with a BMI of > or = 35 kg/m(2) had increased risk for low and high migraine frequency, with the highest estimate for women who reported daily migraine. Compared with women with the lowest associated risk (migraine frequency < 6 times/year; BMI between 27.0 and 29.9 kg/m(2)), women with a BMI > or = 35 kg/m(2) had an OR of daily migraine of 3.11 (1.12, 8.67). Among the women with active migraine, a BMI > or = 35 kg/m(2) was associated with increased risk of phonophobia and photophobia and decreased risk of a unilateral pain characteristic and migraine aura. Our data confirm previous findings that the association between BMI with migraine is limited to migraine frequency and specific migraine features.
Immunology of Atopic Dermatitis: Novel Insights into Mechanisms and Immunomodulatory Therapies (2013)

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that is associated with immune dysregulation and epidermal barrier dysfunction. The imbalance of the Th2 and Th1 pathways and their associated cytokines in AD presents as one facet of the pathogenic mechanisms. Changes in the T-cell populations and the associated cytokines during the acute and chronic phases of AD can cause variations in disease presentations and treatment responses. Continued discoveries in the immunopathogenesis of AD provide optimism for the development of efficacious therapeutic agents. Novel immunomodulatory therapies include apremilast, dupilumab, IL-37, omalizumab, rituximab, mepolizumab, infliximab, allergen-specific immunotherapy, Mycobacterium vaccae, and leflunomide. These agents serve as examples of how modulation in immunopathogenesis of AD can lead to therapeutic discoveries.
Clinical Results Using a Multiple-channel Cochlear Prosthesis (1984)

A total of eight profoundly deaf patients have been implanted with the Nucleus Limited multiple-channel cochlear prosthesis at the University of Melbourne since it became available in late 1982. All patients are everyday users of the device. Speech testing using the device alone has shown consistently high scores for a variety of closed set tests and significant levels of open set speech understanding in most of the patients. Lipreading assessment with phoneme, word, sentence and speech tracking material shows significant improvement when using the prosthesis for all patients tested. Other benefits reported are recognition of environmental sounds, decrease in tinnitus, increased confidence in social and vocational situations and improved voice control. One patient is able to cope with interactive conversations over the telephone and three others are able to use the telephone in a limited way without special codes.
The Appearance of the Tarsal Navicular after Posteromedial Release for Clubfoot (1985)

Sixty-one idiopathic clubfeet in 46 patients of an older population were treated by one-stage posteromedial release. Follow-up roentgenograms revealed dorsal subluxation of the tarsal navicular in 43% of the clubfeet. This abnormality is probably due to both closed manipulation and casting, and improper positioning of the navicular during posteromedial release. However, dorsal navicular subluxation did not adversely affect the results of treatment observed over the follow-up period that averaged nearly 6 1/2 years. Medial subluxation of the navicular was associated with unsatisfactory results, whereas a centrally located or laterally subluxed navicular generally produced good or excellent results. Other abnormalities of the navicular noted included wedging and avascular necrosis. The long-term consequences of these various abnormalities of the roentgenographic appearance and position of the navicular are not known.
Natural variation in <i>ARF18</i> gene simultaneously affects seed weight and silique length in polyploid rapeseed (2015)

Seed weight (SW), which is one of the three major factors influencing grain yield, has been widely accepted as a complex trait that is controlled by polygenes, particularly in polyploid crops. Brassica napus L., which is the second leading crop source for vegetable oil around the world, is a tetraploid (4×) species. In the present study, we identified a major quantitative trait locus (QTL) on chromosome A9 of rapeseed in which the genes for SW and silique length (SL) were colocated. By fine mapping and association analysis, we uncovered a 165-bp deletion in the auxin-response factor 18 (ARF18) gene associated with increased SW and SL. ARF18 encodes an auxin-response factor and shows inhibitory activity on downstream auxin genes. This 55-aa deletion prevents ARF18 from forming homodimers, in turn resulting in the loss of binding activity. Furthermore, reciprocal crossing has shown that this QTL affects SW by maternal effects. Transcription analysis has shown that ARF18 regulates cell growth in the silique wall by acting via an auxin-response pathway. Together, our results suggest that ARF18 regulates silique wall development and determines SW via maternal regulation. In addition, our study reveals the first (to our knowledge) QTL in rapeseed and may provide insights into gene cloning involving polyploid crops.
An efficient conversion of quantum circuits to a linear nearest neighbor architecture (2011)

Several promising implementations of quantum computation rely on a Linear Nearest Neighbor (LNN) architecture, which arranges quantum bits on a line, and allows neighbor interactions only. Therefore, several specific circuits have been designed on an LNN architecture. However, a general and efficient conversion method for an arbitrary circuit has not been established. Therefore, this paper gives an efficient conversion technique to convert quantum circuits to an LNN architecture. When a quantum circuit is converted to an LNN architecture, the objective is to reduce the size of the additional circuit added by the conversion and the time complexity of the conversion. The proposed method requires less additional circuitry and time complexity compared with naive techniques. To develop the method, we introduce two key theorems that may be interesting on their own. In addition, the proposed method also achieves less overhead than some known circuits designed from scratch on an LNN architecture.
Synergistic effects of thiocyanate additive and cesium cations on improving the performance and initial illumination stability of efficient perovskite solar cells (2018)

The combination of Pb(SCN)<sub>2</sub> and CsPbI<sub>3</sub> results in high quality perovskite films, leading to high performance PVSCs with a stable power output.
A Failure Detection and Prediction Mechanism for Enhancing Dependability of Data Centers (2012)

 Abstract—Modern data centers continue to grow in their scale and complexity. They are changing dynamically as well due to the addition and removal of system components, changing execution environments, frequent updates and upgrades, online repairs and more. Classical reliability theory and conventional methods do rarely consider the actual state of a system and are therefore not capable to reflect the dynamics of runtime systems and failure processes. In this paper, we present an unsupervised failure detection and prediction method using an ensemble of Bayesian models. It characterizes normal execution states of the system and detects anomalous behaviors. We implement a prototype of our failure detection and prediction mechanism and evaluate its performance on a data center test platform. Experimental results show that our proposed method can forecast failure dynamics with high accuracy.
An IFN- <i>β</i> -Albumin Fusion Protein That Displays Improved Pharmacokinetic and Pharmacodynamic Properties in Nonhuman Primates (2003)

The long half-life and stability of human serum albumin (HSA) make it an attractive candidate for fusion to short-lived therapeutic proteins. Albuferon (Human Genome Sciences [HGS], Inc., Rockville, MD) beta is a novel recombinant protein derived from a gene fusion of interferon-beta (IFN-beta ) and HSA. In vitro, Albuferon beta displays antiviral and antiproliferative activities and triggers the IFN-stimulated response element (ISRE) signal transduction pathway. Array analysis of 5694 independent genes in Daudi-treated cells revealed that Albuferon beta and IFN-beta induce the expression of an identical set of 30 genes, including 9 previously not identified. In rhesus monkeys administered a dose of 50 microg/kg intravenously (i.v.) or subcutaneously (s.c.) or 300 microg/kg s.c., Albuferon beta demonstrated favorable pharmacokinetic properties. Subcutaneous bioavailability was 87%, plasma clearance at 4.7-5.7 ml/h/kg was approximately 140-fold lower than that of IFN-beta, and the terminal half-life was 36-40 h compared with 8 h for IFN-beta. Importantly, Albuferon beta induced sustained increases in serum neopterin levels and 2',5' mRNA expression. At a molar dose equivalent to one-half the dose of IFN-beta, Albuferon beta elicited comparable neopterin responses and significantly higher 2',5'-OAS mRNA levels in rhesus monkeys. The enhanced in vivo pharmacologic properties of IFN-beta when fused to serum albumin suggest a clinical opportunity for improved IFN-beta therapy.
Combined Current Integrator and Sensitive Microammeter (1952)

A simple current integrator has been designed for use in connection with electrostatic accelerators. It is capable of integrating currents higher than 10−8 ampere. A compensation resistor in the input circuit of the integrator is at the same time utilized as a shunt resistor for an electronic microammeter with full-scale readings, 1, 2, and 10 μa.
ARYLOXYPROPANE DERIVATIVES (1953)

Journal Article ARYLOXYPROPANE DERIVATIVES Get access V Petrow, V Petrow Research Laboratories, The British Drug Houses Ltd., London, N.1 Search for other works by this author on: Oxford Academic Google Scholar O Stephenson O Stephenson Research Laboratories, The British Drug Houses Ltd., London, N.1 Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 5, Issue 1, August-September 1953, Pages 359–369, https://doi.org/10.1111/j.2042-7158.1953.tb13997.x Published: 12 April 2011 Article history Received: 02 April 1953 Published: 12 April 2011
HOT-PRESSED POLYCRYSTALLINE CaF2:Dy2+ LASER (1964)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S. E. Hatch, W. F. Parsons, R. J. Weagley; HOT‐PRESSED POLYCRYSTALLINE CaF2:Dy2+ LASER. Appl. Phys. Lett. 15 October 1964; 5 (8): 153–154. https://doi.org/10.1063/1.1754094 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Surface modification of polymers by direct fluorination: A convenient approach to improve commercial properties of polymeric articles (2009)

Abstract The fundamental features and industrial applications of the direct fluorination of polymers are reviewed. Direct fluorination of polymers (i.e., treatment of a polymer surface with gaseous fluorine mixtures) proceeds spontaneously at room temperature and is a surface modification process. More than 25 polymers have been studied with the aid of a variety of analytical and spectroscopic techniques. The fundamental features of the direct fluorination, such as influence of treatment conditions (composition of the fluorinating mixture, fluorine partial pressure, temperature, and fluorination duration) on the rate of formation, chemical composition, density, refraction index, and surface energy of the fluorinated layer, kinetics of formation of radicals during fluorination and their termination, texture of fluorinated layer, etc. were studied. It was demonstrated experimentally that direct fluorination can be effectively used to enhance commercial properties of polymer articles, such as barrier properties of polymer vessels, bottles, and packaging films and envelopes; gas-separation properties of polymer membranes; adhesion and printability properties of polymer articles; and mechanical properties of polymer-based composites.
Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy (2011)

Higher pre-ART CD8(+) T-cell activation independently predicts slower CD4(+) T-cell recovery and higher persistent CD8(+) T-cell activation during ART-mediated viral suppression independently predicts increased mortality among HIV-infected Ugandans. Novel therapeutic strategies aimed at preventing or reversing immune activation during ART are needed in this setting.
Output voltage control method of PWM-controlled cycloconverters with space vectors. (1990)

A new output voltage control method for PWM-controlled cycloconverters with space vectors is proposed in this paper. Results are as follows :
Pharmacokinetics of Melatonin in Man: First Pass Hepatic Metabolism (1985)

Hepatic clearance concepts were applied to existing data on iv and oral administration of melatonin to man. A high hepatic extraction ratio was calculated, suggesting prominent first pass hepatic metabolism and reduced bioavailability for orally administered melatonin. Using clearance parameters and previous data, endogenous production rates for melatonin were determined for normal individuals and patients with cirrhosis. Normal melatonin production was 28.8 micrograms/day, while the production rate for cirrhotic patients was 12.3 micrograms/day. Thus, not only do cirrhotic patients have decreased melatonin elimination, as noted in the original report, but they also have decreased daily melatonin production.
Issues of critical airway management (Which anesthesia; which surgical airway?) (2012)

Which anesthesia for patients with critical airway? Safe and effective analgesia and anesthesia in critical airway is a skilled task especially after severe maxillofacial injury combined with head injury and hemorrhagic shock. If on one side sedation is wanted, on the other hand it may worsen the airway and hemodynamic situation to a point where hypoventilation and decrease of blood pressure, common side-effect of many opioids, may prejudice the patient's level of consciousness and hemodynamic compensation, compounding an already critical situation. What to do when endotracheal intubation fails and blood is trickling down the airways in an unconscious patient or when a conscious patient has to sit up to breathe? Which surgical airway in critical airway? Comparative studies among the various methods of emergency surgical airway would be unethical; furthermore, operator's training and experience is relevant for indications and performance.
Influenza virus‐like particles engineered by protein transfer with tumor‐associated antigens induces protective antitumor immunity (2015)

Delivery of antigen in particulate form using either synthetic or natural particles induces stronger immunity than soluble forms of the antigen. Among naturally occurring particles, virus-like particles (VLPs) have been genetically engineered to express tumor-associated antigens (TAAs) and have shown to induce strong TAA-specific immune responses due to their nano-particulate size and ability to bind and activate antigen-presenting cells. In this report, we demonstrate that influenza VLPs can be modified by a protein transfer technology to express TAAs for induction of effective antitumor immune responses. We converted the breast cancer HER-2 antigen to a glycosylphosphatidylinositol (GPI)-anchored form and incorporated GPI-HER-2 onto VLPs by a rapid protein transfer process. Expression levels on VLPs depended on the GPI-HER-2 concentration added during protein transfer. Vaccination of mice with protein transferred GPI-HER-2-VLPs induced a strong Th1 and Th2-type anti-HER-2 antibody response and protected mice against a HER-2-expressing tumor challenge. The Soluble form of GPI-HER-2 induced only a weak Th2 response under similar conditions. These results suggest that influenza VLPs can be enriched with TAAs by protein transfer to develop effective VLP-based subunit vaccines against cancer without chemical or genetic modifications and thus preserve the immune stimulating properties of VLPs for easier production of antigen-specific therapeutic cancer vaccines.
Research on the positioning method of cruise missile based CDMA mobile communication network (2011)

Passive detection technology is the current hot research field of electronic countermeasures. In this paper, proposed an cruise missile detecting method based on the CDMA mobile communication network, and did some research on the positioning method based on the difference time of arrival, and then proposed the position error model. The simulation results show that the method proposed in the paper is effective.
The Orthotic Treatment of Stable Ankle Fractures (1984)

Fifteen limbs with stable lateral malleolar fractures treated with an adjustable, functional orthosis were compared to 12 limbs managed with short leg walking casts. The limbs managed with the adjustable orthosis were clinically healed at an average of 3.3 weeks with no fracture tenderness and with the ability to bear full weight without pain. Range of motion in the orthotic group at the end of treatment was significantly better than the casted group. Patient compliance was excellent. The advantages of the orthotic treatment include a more physiologic gait pattern due to the rocker bottom sole, ease of application, lighter weight, removability for range of motion exercises and bathing, and adjustability to maintain a good fit as posttraumatic swelling resolves.
Determination of anionic-active matter in detergents by potentiometric titration (1980)

A potentiometric titration method for the determination of anionic-active matter in commercial detergents is presented as an alternative to the two-phase, colour-indicator titrations commonly used. An easily made membrane electrode is used to indicate the end-point of titrations with a standard solution of cationic surfactant.
Azathioprine as a single immunosuppressive drug in the treatment of myasthenia gravis. (1993)

We retrospectively evaluated results obtained from azathioprine (AZA) treatment on a selected sample of 40 patients affected by autoimmune myasthenia gravis (MG). Patients received AZA as a single immunosuppressive drug for at least 2 years. Twenty out of 40 patients received also a one-month course of cyclophosphamide (CP) before starting AZA. All patients started immunosuppressive treatment out of myasthenic crisis. After 3, 12 and 24 months of AZA treatment, 82.5%, 92.5% and 97.5% of the patients respectively showed improvement in functional state, disappearance of bulbar involvement, or both. The impressive percentage of short-term positive results did not seem influenced by pre-treatment by CP. Side effects included only minor and transitory gastrointestinal symptoms and reversible cytopenia. Although the patient population was either particularly suitable for AZA treatment or candidate to a better response, our data suggest that AZA might also have good short term effects in a subgroup of MG patients.
Some Consequences of Having Too Little (2012)

Poor individuals often engage in behaviors, such as excessive borrowing, that reinforce the conditions of poverty. Some explanations for these behaviors focus on personality traits of the poor. Others emphasize environmental factors such as housing or financial access. We instead consider how certain behaviors stem simply from having less. We suggest that scarcity changes how people allocate attention: It leads them to engage more deeply in some problems while neglecting others. Across several experiments, we show that scarcity leads to attentional shifts that can help to explain behaviors such as overborrowing. We discuss how this mechanism might also explain other puzzles of poverty.
Polymer Matrix Composites Subjected to Low Velocity Impact: Effect of Fibre Volume Fraction (2000)

Article Polymer Matrix Composites Subjected to Low Velocity Impact: Effect of Fibre Volume Fraction was published on December 1, 2000 in the journal Science and Engineering of Composite Materials (volume 9, issue 4).
원저 : ICU 환자에서 Pulse Oximetry 에 대한 임상적 평가 (1988)

Continuous assessment of arterial oxygenation is important in the clinical management of critically ill patients. Analysis of arterial blood gas is reliable but is invasive and only provides intermittent informations. In order to determine the accuracy of pulse oximeters in ICU patients, arterial oxygen saturation was measured in 58 patients in ICU using two kinds of pulse oximeters (Ohmeda, CSI), while simutaneously analyzing arterial blood gases. The relationship between the pulse oximeters saturation (SpO2,) and arterial oxygen saturation (SaO2,) was evaluated. Group I consisted of 102 samples of SpO2 using an Ohm a pulse oximter in 45 of 72 patients. Group II included 102 samples of SpO2, using a CSI pulse oximeter in 45 of 72 patients. Both Ohmeda and CSI pulse oximeters were applied to 32 patients. Group Ⅲ had 204 samples, the sum of Groups I and II. The results were as follow; The correlation coefficients of SpO2, to SaO2, in Groups 1, II and Ⅲ were 0.97, 0.90 and 0.96 (p < 0.005). 2) Mean difference between S2aO, and SpO2 in Groups I, II and III were almost within the limit of 1%. 3) The correlation coefficient of SpO2 between Ohmeda and CSI pulse oximeter was 0.79, and there was no mean difference between them in the 32 patients who were tested with both the Ohmeda and the CSI pulse oximeters. In conclusion, a pulse oximter is an accurate noninvasive device which assesses arteria1 oxygenation and provides information continuously, Wider clinical indication will follow.