gebhart/patrepeval huggingface dataset:
Brachytherapy of recurrent malignant brain tumors with removable high-activity iodine-125 sources (1984)

Thirty-seven patients harboring recurrent malignant primary or metastatic brain tumors were treated by 40 implantations of high-activity iodine-125 (125I) sources. All patients had been treated with irradiation and most had been treated with chemotherapeutic agents, primarily nitrosoureas. Implantations were performed using computerized tomography (CT)-directed stereotaxy; 125I sources were held in one or more afterloaded catheters that were removed after the desired dose (minimum tumor dose of 3000 to 12,000 rads) had been delivered. Patients were followed with sequential neurological examinations and CT scans. Results of 34 implantation procedures were evaluable: 18 produced documented tumor regression (response) for 4 to 13+ months; five, performed in deteriorating patients, resulted in disease stability for 4 to 12 months. The overall response rate was 68%. In 11 patients, implantation did not halt clinical deterioration. At exploratory craniotomy 5 to 12 months after implantation, focal radiation necrosis was documented in two patients whose tumor had responded initially and then progressed, and in three patients whose disease had progressed initially (four glioblastomas, one anaplastic astrocytoma); histologically identifiable tumor was documented in two of these patients. All improved after resection of the focal necrotic mass and are still alive 10, 15, 19, 24, and 25 months after the initial implantation procedure; only one patient has evidence of tumor regrowth. The median follow-up period after implantation for the malignant glioma (anaplastic astrocytoma and glioblastoma multiforme) group is 9 months, with 48% of patients still surviving. While direct comparison with the results of chemotherapy is difficult, results obtained in this patient group with interstitial brachytherapy are probably superior to results obtained with chemotherapy.
Heterogeneous Data Integration with ELT and Analytical MPP Database for Data Analysis Application (2021)

Ina data analysis project, data integration is per-formed on a large volume of data collection from heterogeneous sources. Projects need to collect data from Web API, nonrelational, Relational databases, Edge AI, Connected Vehicles, Structured and Unstructured Files, and system logs. Before storing, data will be collected, Validated, and Transformed. This process is created in Extract Load Transform (ELT) and scheduled. Traditional Extract Transform and Load (ETL) systems process the data before loading it into the database, and the data transformation needs dedicated resources in the ETL server. Projects often encounter performance issues and high hardware and licensing costs while processing extensive data set, and this is handled efficiently in Extract Load and Transform (ELT) and Analytical Massively Parallel Processing (MPP). Data transform will take place in MPP Databases, and the resources are highly scalable in the cloud. ELT with Analytical MPP makes data analysis much faster and more efficient. We will discuss the roles of ETL and ELT tools in data integration for a successful data science application.
The projection score - an evaluation criterion for variable subset selection in PCA visualization (2011)

We conclude that the projection score provides an easily interpretable and universally applicable measure of the informativeness of a variable subset with respect to visualization by PCA, that can be used to systematically find the most interpretable PCA visualization in practical exploratory analysis.
A Test of Neutral Molecular Evolution Based on Nucleotide Data (1987)

The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of polymorphism within species. We present here a conservative statistical test of this prediction based on a constant-rate neutral model. The test requires data from an interspecific comparison of at least two regions of the genome and data on levels of intraspecific polymorphism in the same regions from at least one species. The model is rejected for data from the region encompassing the Adh locus and the 5' flanking sequence of Drosophila melanogaster and Drosophila sechellia. The data depart from the model in a direction that is consistent with the presence of balanced polymorphism in the coding region.
The low affinity 40,000 Fc <i>gamma</i> receptor and the transferrin receptor can be alternative or simultaneous target structures on cells sensitive for natural killing. (1986)

The role of the low avidity 40,000 dalton receptor for IgG (Fc gamma R) present on K562 and U937 cells in sensitivity to natural killing (NK) was studied by using a murine monoclonal antibody (mAb) specific for the 40,000 dalton Fc gamma R (alpha Fc gamma R mAb). Pretreatment of K562 target cells with intact alpha Fc gamma R mAb or its Fab fragment or anti-transferrin receptor (alpha TFR) mAb partially blocked in a dose-dependent manner, NK activity to K562 cells. However, combined pretreatment with alpha Fc gamma R and alpha TFR mAb completely blocked NK activity against K562 targets. As compared with K562 cells, lower levels of NK were elicited against Molt-4, U937, HL-60, and Daudi targets. Although NK activity to Molt-4 targets was not affected by alpha Fc gamma R mAb, it was fully prevented by pretreatment with alpha TFR mAb. In contrast, NK to U937 cells was not influenced by alpha TFR mAb, but it was strongly inhibited by alpha Fc gamma R mAb. The resistance of 3H-TdR-prelabeled adherent HEp-2 cells to natural cell-mediated cytotoxicity was not affected by either mAb. Lectin-dependent cell-mediated cytotoxicity (LDCC) against HEp-2 cells due to the presence of concanavalin A, and was completely abrogated by pretreatment of the targets with alpha TFR mAb, but was unaffected by alpha Fc gamma R mAb. By use of the flow cytometer, a significant correlation was detected between the relative expression of 40,000 dalton Fc gamma R and the susceptibility to NK, whereas the expression of TFR was discordant from NK sensitivity. As determined in the single cell cytotoxicity assay alpha Fc gamma R mAb reduced the frequency of target binding effector cells without affecting the number of dead bound targets. This pattern of inhibition was found against both K562 and U937 targets. Alternatively, alpha TFR mAb inhibited both binding and killing of K562 and Molt-4 targets. Because pretreatment of HEp-2 cells with alpha TFR mAb did not influence conjugate formation, the blocking of LDCC to HEp-2 cells by alpha TFR mAb can be related to post-binding events. These data show that although both the 40,000 dalton Fc gamma R and the TFR can be target structures for NK cell recognition, the TFR may also play an important role in the post-binding events.
Efficacy and Safety of Raloxifene 60 Milligrams/Day in Postmenopausal Asian Women (2003)

In healthy Caucasian postmenopausal women, raloxifene increases bone mineral density (BMD), decreases biochemical markers of bone turnover, and lowers low-density lipoprotein (LDL) cholesterol, without effects on high-density lipoprotein (HDL) cholesterol and triglycerides. This randomized, double-blind study examines the effects of raloxifene 60 mg/d (n = 483) or placebo (n = 485) in healthy postmenopausal Asian women (mean age 57 yr) from Australia, Hong Kong, India, Indonesia, Malaysia, Pakistan, Philippines, Singapore, Taiwan, and Thailand. Serum osteocalcin, serum N-telopeptide, total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were assessed at baseline and 6 months. Lumbar spine BMD was measured at baseline and 1 yr in 309 women from 4 countries. Clinical adverse events were recorded at each interim visit. At 6 months, raloxifene 60 mg/d significantly decreased osteocalcin, N-telopeptide, total cholesterol, and LDL cholesterol by medians of 15.9%, 14.6%, 5.3%, and 7.7%, respectively, from placebo. Changes in HDL cholesterol and triglycerides were similar between raloxifene and placebo. Raloxifene 60 mg/d increased mean lumbar spine BMD (1.9%) from placebo at 1 yr (P = 0.0003). The incidences of hot flashes (placebo 3.5%, raloxifene 5.6%, P = 0.12), and leg cramps (placebo 2.7%, raloxifene 4.3%, P = 0.16) were not different between groups. No case of venous thromboembolism was reported. The effects of raloxifene 60 mg/d on bone turnover, BMD, and serum lipids in healthy postmenopausal Asian women were similar to that previously reported in Caucasian women.
Lymphocyte surface markers in acute rheumatic fever and post-streptococcal acute glomerulonephritis. (1977)

Lymphocyte cell-surface markers were examined in forty children with acute rheumatic fever (ARF) and twelve with acute post-streptococal glomerulonephritis (AGN) and compared to thirty-six normal controls of similar age. Cell-surface-marker studies included surface Ig using fluorescein-labelled F(ab)2 anti-F(AB')2, IgG aggregate binding cells, and EAC rosettes. T cells were identified both as 'active' rosettes and total E-binding cells. Proportions and absolute numbers of cells bearing surface Ig and Fc receptors were elevated in subjects with AGN (Pless than0-01-0-5), whereas proportions of cells producing EAC rosettes were diminished. Patients with acute rheumatic carditis or chorea showed a substantial elevation in proportions and numbers of active T-cell rosettes (Pless than0-01). Streptococcal antigen binding cells capable of forming rosettes with autologous cells coated with group A streptococcal membranes were elevated in the acute phase of both rheumatic fever and acute glomerulonephritis(Pless than0-01). The majority of such cells were removed by passage over insolubilized Ig-anti-IgG columns and appeared to be B cells.
Software Defined Optical Networks Technology and Infrastructure: Enabling Software-Defined Optical Network Operations (2013)

A control plane architecture based on OpenFlow for optical SDN is introduced. Requirements for its implementation are discussed considering emerging optical transport technologies. Two implementations of the architecture and results on their performance are reported.
Selective Radiation Properties of Particulate Coatings (1963)

The variation with wavelength of thermal radiation properties of coated surfaces is important for solar energy absorbers and in other applications, and depends on the optical properties of the coating material and the substrate, and on the structure of the coating. Theoretical considerations indicate that, for homogeneous coatings, the good optical properties of semiconductors can be improved if the coating contains a high fraction of voids. This improvement has been shown by experimental particulate PbS coatings which are not homogeneous; the selective properties of particulate coatings are better than those calculated for solid coatings at the same coating weight. PbS coatings on aluminum substrates show absorptances for solar radiation of 0.9 and long wave emittance of 0.2 to 0.3. The feasibility of selective paints has been demonstrated; PbS can be mixed with a transparent binder, silicone, to make a paint which shows a good degree of selectivity, and absorptances of 0.9 and emittances less than 0.4 have been obtained.
Secretion of a Nerve Growth Factor by Primary Chick Fibroblast Cultures (1975)

Normal primary chick embryo fibroblast cultures product a nerve growth-promoting factor which cross-reacts with monospecfic antibody to pure male mouse submaxillary gland nerve growth factor (NGF). When taken together with the earlier demonstration that mouse L2 CELLS AND 3T3 cells also produce an NGF-like protein, these findings suggest that secretion of this factor may be a general property of fibroblast.
A computationally efficient algorithm for state-to-state quadrocopter trajectory generation and feasibility verification (2013)

An algorithm is proposed allowing for the rapid generation and evaluation of quadrocopter state interception trajectories. These trajectories are from arbitrary initial states to final states defined by the vehicle position, velocity and acceleration with a specified end of time. Sufficient criteria are then derived allowing trajectories to be tested for feasibility with respect to thrust and body rates. It is also shown that the range of a linear combination of the vehicle state can be solved for in closed form, useful e.g. for testing that the position remains within a box. The algorithm is applied by revisiting the problem of finding a trajectory to hit a ball towards a target with a racket attached to a quadrocopter. The trajectory generator is used in a model predictive control like strategy, where thousands of trajectories are generated and evaluated at every controller update step, with the first input of the optimal trajectory being sent to the vehicle. It is shown that the method can generate and evaluate on the order of one million trajectories per second on a standard laptop computer.
Detection of Cryptdin in Mouse Skin (1999)

Defensins are widely distributed and broad-spectrum antimicrobial peptides with activities against bacteria, fungi, and enveloped viruses. Defensins have been isolated from granules of neutrophils from humans, rabbits, rats, and guinea pigs. They have also been found in lung macrophages as well as in Paneth cells of the human, rabbit, and mouse small intestine. The human beta-defensin-2 was recently isolated from human skin. In this study, we detected the expression of mRNA for the defensin cryptdin in BALB/c mouse skin by means of reverse transcriptase PCR amplification. Expression was also detected in dispase-separated epidermis and cultured keratinocytes, but expression was not detected in fibroblasts. The expression of cryptdin mRNA was found to begin on embryonic day 17.5. As determined with specific primers, the cDNA sequence cloned from the skin was found to be identical to that previously reported for cryptdin-5. cDNA derived from cultured keratinocytes demonstrated the sequences of the cryptdin-6 and cryptdin-1 isoforms. In situ hybridization analysis showed that the mRNA of cryptdin was expressed in the suprabasal keratinocytes of the skin in embryonic and neonatal days and then shifted to the hair bulbs in the skin of adult mice.
Refined channel estimation for coherentdetection of turbo codes over flat-fading channels (1998)

Channel state information is required for the coherent detection and decoding of turbo codes transmitted over flat-fading channels. A channel estimation technique suitable for turbo codes is presented. The technique uses pilot symbols to obtain initial channel estimates, and refines the estimates after each iteration of the turbo decoder.
Suppression of the coffee-ring effect by shape-dependent capillary interactions (2012)

Coffee rings have hidden depths When a drop of coffee dries, a halo of particles accumulates at the drop's edge. This 'coffee-ring effect', first described formally in a Nature paper in 1997, is a common occurrence when a solution of suspended colloidal particles evaporates. Far from being just a household curiosity, it has turned out to have relevance for many applications in which a uniform particle deposition is required, such as inkjet printing, assembly of photonics components and manufacture of DNA chips. In this issue, Peter Yunker and colleagues show that ellipsoidal particles suppress the coffee-ring effect. Attractive interparticle interactions between ellipsoids are sufficiently strong to counteract the forces that drive spherical particles towards the drop's edge as the drop evaporates. The coffee-ring effect can be restored for ellipsoids in solution containing surfactant, and 'designed' mixtures of spheres and ellipsoids can lead to uniform deposition.
Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes. (1992)

Leishmania are obligatory intracellular parasites in mammalian macrophages that gain entry by receptor-mediated phagocytosis. Their major cell surface glycoconjugate, lipophosphoglycan (LPG), has been implicated in this process. A monoclonal antibody specific for Leishmania major LPG (WIC 79.3), which has been shown to block promastigote attachment to macrophages, was used to identify a macrophage-binding determinant of LPG. WIC 79.3 bound exclusively to the phosphorylated repeats of LPG and not to the saccharide core or lipid anchor. Furthermore, the epitope recognized by WIC 79.3 mapped to the phosphorylated oligosaccharide P5b, PO4-6[Gal(beta 1-3)Gal(beta 1-3)Gal(beta 1-3)]Gal(beta 1-4)Man(alpha 1-, which is unique to the LPG of promastigotes of L.major. Phosphorylated oligosaccharides P3, PO4-6[Gal(beta 1-3)[Gal(beta 1-4) Man(alpha 1-, and P4b, PO4-6[Gal(beta 1-3)Gal(beta 1-3)] Gal(beta 1-4)Man(alpha 1-, were also recognized by WIC 79.3 but with considerably lower (approximately 100-fold) affinities. The phosphorylated oligosaccharide P5b inhibited attachment of promastigotes of L. major to the macrophage cell line J774 to the same degree as phosphoglycan (derived from LPG) and Fab fragments of WIC 79.3, suggesting that P5b is a site of L. major LPG that is recognized by macrophage receptor(s) and is an important determinant in the attachment of promastigotes to host macrophages and initiation of infection.
A New Method for Haptoglobin Phenotyping (1999)

Haptoglobin is an acute-phase protein with three major phenotypes: Hp 1-1, Hp 2-1 and Hp 2-2. Studies have shown that functional differences between these phenotypes have important consequences in a number of pathological disorders (e.g. cardiovascular disease, autoimmune disorders, infectious disease), making phenotype determination of potential use in the clinical field. Previous methods for haptoglobin phenotyping have involved electrophoresis (starch, acetate and polyacrylamide gels) with phenotype visualization by peroxidase-sensitive stains that were often carcinogenic. Less hazardous immunoblotting and isoelectric focusing procedures are also available but the methods are lengthy, expensive and often complex. Here, we describe a new method for haptoglobin phenotyping using commercially available agarose gels and a non-carcinogenic stain (3,3',5,5'-tetramethylbenzidine). Our method showed 100% agreement with starch gel electrophoresis and reliably distinguished between commercial haptoglobin phenotype standards and serum samples from patients (n = 125). We obtained a sensitivity of 0.4 g/L for all phenotypes and the gels were stable for up to 2 months. This safer and easier to use method may permit increased access to knowledge of haptoglobin phenotype, allowing improved patient management and better tailoring of treatment in a variety of clinical conditions.
Evaluation of data-parallel splitting approaches for H.264 decoding (2008)

The high computational demands of the H.264 decoding process pose serious challenges on current processor architectures. A natural way to tackle this problem is the use of multi-core systems. The contribution of this paper lies in a systematic overview and performance evaluation of parallel video decoding approaches. Our study investigates six methods for accomplishing data-parallel splitting in strongly resource-restricted environments inherent to mobile devices. These methods are compared against each other in terms of run-time complexity, core usage, inter-communication and bus transfers. We present benchmark results using different numbers of processor cores. Our results shall aid in finding a splitting strategy that is best suited for the targeted hardware-architecture.
Successful Isolation of a Water Contribution Zone Using Fiber Optic Telemetry Enabled Coiled Tubing Conveyed Inflatable Packer Capped with Cement (Case Study) (2010)

Abstract High water production may cause adverse effects on reservoir performance, which can result in production losses. To mitigate this situation it is crucial to utilize water management to reduce water production, optimize oil production, increase the well life and revive dead wells. One feasible option to isolate the water producing zone is a rigless water shut off (WSO) using mechanical isolation. This kind of operation is more challenging for horizontal wells with open hole completion. This paper will demonstrate the impact of a successful WSO on overall performance of a horizontal open hole producer with 4,600 ft of reservoir contact. The well produced with 58.5% water cut and the production log showed that most of the water was coming from the toe of the horizontal section. This paper highlights a mechanical rigless WSO method used to isolate a water contribution zone using a fiber optic telemetry enabled coiled tubing (CT) conveyed inflatable packer capped with cement. Fiber Optic Coil Tubing (FOCT) provides real- time downhole temperature, pressure (inside and outside the CT) and casing collar locator (CCL) measurements used to achieve accurate packer setting depth, confirm packer setting and ensure the suitability of the cement recipe. The complete cycle of candidate selection is addressed.
Preparation of optically active 6-chlorotryptophan and tryptophan (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of optically active 6-chlorotryptophan and tryptophanShigeki. Yamada, Masao. Yamamoto, Chikara. Hongo, and Ichiro. ChibataCite this: J. Agric. Food Chem. 1975, 23, 4, 653–657Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/jf60200a010https://doi.org/10.1021/jf60200a010research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Well-Defined Alternating Copolymers of Oligo(phenylenevinylene)s and Flexible Chains (2012)

A series of alternating copolymers containing oligomeric bis(2-ethylhexyl)-p-phenylenevinylene (BEH-PPV) chromophores and conformational-flexible n-decyl or tetraethylene glycol chains were prepared. The polymerization was carried out using Sonogashira coupling conditions between monomers composed of an iodo-terminated PPV oligomer (trimer, pentamer, or septamer) and a bis(phenylacetylene)-containing flexible chain. Polymers containing the n-decyl chain attained higher molecular weights compared to the tetraethylene glycol-containing polymers. 4-Ethynylanisole-capped oligomers (trimer, pentamer, or septamer) were prepared, and their solution photophysical properties were compared to the analogous polymeric materials. The solution optical properties of the polymers were primarily determined by chromophore length of the constituent oligomers. In contrast, the thin film fluorescence spectra of the polymers showed substantial differences between n-decyl and tetraethylene glycol containing materials, suggesting significant changes in the degree of interchain coupling in the solid state. The control of effective conjugation length afforded by these materials makes them a promising system for understanding electronic trap states in conjugated polymers.