gebhart/patrepeval huggingface dataset:
On arbitrating the power-performance tradeoff in SaaS clouds (2013)

In this paper, we present an analytical framework for characterizing and optimizing the power-performance tradeoff in Software-as-a-Service (SaaS) cloud platforms. Our objectives are two-fold: (1) We maximize the operating profit when serving heterogeneous SaaS applications with unpredictable user requests, and (2) we minimize the power consumption when processing user requests. To achieve these objectives, we take advantage of Lyapunov Optimization techniques to design and analyze an optimal control framework to make online decisions on request admission control, routing, and virtual machine (VMs) scheduling. In particular, our control framework can be flexibly extended to incorporate various design choices and practical requirements of a data-center in the cloud, such as enforcing a certain power budget for improving the performance (dollar) per watt. Our mathematical analyses and simulations have demonstrated both the optimality (in terms of a cost-effective power-performance tradeoff) and system stability (in terms of robustness and adaptivity to time-varying and bursty user requests) achieved by our proposed control framework.
TiO<sub>2</sub>(B) Nanowires as an Improved Anode Material for Lithium‐Ion Batteries Containing LiFePO<sub>4</sub> or LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> Cathodes and a Polymer Electrolyte (2006)

Rechargeable lithium-ion batteries have been constructed with a TiO2(B) nanowire anode, a gel electrolyte, and either a LiFePO4 or LiNi0.5Mn1.5O4 cathode. Cycling stability is very good as is rate capability (see figure), with 80% of the low-rate capacity being retained at C/5. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c1232_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
<title>Detection of cocaine in cargo containers by high-volume vapor sampling: field test at Port of Miami</title> (1997)

The use of marine containers is a well known smuggling method for large shipments of drugs. Such containers present an ideal method of smuggling as the examination method is time consuming, difficult and expensive for the importing community. At present, various methods are being studied for screening containers which would allow to rapidly distinguish between innocent and suspicious cargo. Air sampling is one such method. Air is withdrawn for the inside of containers and analyzed for telltale vapors uniquely associated with the drug. The attractive feature of the technique is that the containers could be sampled without destuffing and opening, since air could be conveniently withdrawn via ventilation ducts. In the present paper, the development of air sampling methodology for the detection of cocaine hydrochloride will be discussed, and the results from a recent field test will be presented. The results indicated that vapors of cocaine and its decomposition product, ecgonidine methyl ester, could serve as sensitive indicators of the presence of the drug in the containers.
[Endoscopic argon gas coagulation--initial clinical experiences]. (1993)

Argon-gas-coagulation represents a new method of contact free electrocoagulation, where RF-energy is applied to the tissue by means of ionized argon-gas. In the operative field argon-gas-coagulation has been used with success for hemostasis in several parenchymatous organs and for devitalization of various tissues. Experimental studies have shown the superiority of argon-gas-coagulation over standard electrocoagulation and surgical techniques due to its high efficiency and limited tissue traumatization. Having developed and designed special endoscopic probes and after in-vitro-studies we could utilize the method in flexible endoscopy as well. From June 1991 to September 1992, 102 patients were treated in 189 sessions with argon-gas-coagulation in the upper and lower gastrointestinal tract as well as respiratory system. The indications were: malignant and benign tumors, diffuse hemorrhages of various origins and of various sites, tissue overgrowth after stent-implantation, remaining tissue after endoscopic adenomectomy and conditioning of fistulas prior to fibrin sealing. In all cases argon-gas-coagulation in flexible endoscopy has been shown to be a very effective and easy to perform technique with advantages in comparison to standard electrocoagulation. Problems and complications have not been observed. The limited depth of tissue penetration (2-3 mm) coincident with efficient tissue coagulation allows the application even in critical areas such as the duodenum or colon. In many indications argon-gas-coagulation has replaced the former widely used Nd-YAG-laser in our unit. Except vaporisation of extended tumors, the argon-gas-coagulator shows remarkable advantages for nearly all applications.(ABSTRACT TRUNCATED AT 250 WORDS)
Identification of Essential Amino Acids within the Proposed CuA Binding Site in Subunit II of Cytochrome c Oxidase (1995)

To explore the nature of proposed ligands to the CuA center in cytochrome c oxidase, site-directed mutagenesis has been initiated in subunit II of the enzyme. Mutations were introduced into the mitochondrial gene from the yeast Saccharomyces cerevisiae by high velocity microprojectile bombardment. A variety of single amino acid substitutions at each of the proposed cysteine and histidine ligands (His-161, Cys-196, Cys-200, and His-204 in the bovine numbering scheme), as well as at the conserved Met-207, all result in yeast which fails to grow on ethanol/glycerol medium. Similarly, all possible paired exchange Cys,His and Cys,Met mutants show the same phenotype. Furthermore, protein stability is severely reduced as evidenced by both the absence of an absorbance maximum at 600 nm in the spectra of mutant cells and the underaccumulation of subunit II, as observed by immunolabeling of mitochondrial extracts. In the same area of the protein, a variety of amino acid substitutions at one of the carboxylates previously implicated in binding cytochrome c, Glu-198, allow (reduced) growth on ethanol/glycerol medium, with normal intracellular levels of protein. These results suggest that a precise folding environment of the CuA site within subunit II is essential for assembly or stable accumulation of cytochrome c oxidase in yeast.
Stimulation of poly(A) tail elongation by the VP39 subunit of the vaccinia virus-encoded poly(A) polymerase. (1993)

The VP55 subunit of the vaccinia virus-encoded poly(A) polymerase can add a maximum of 35 adenylates to the 3'-end of an RNA primer in a rapid and highly processive manner, whereas the VP55-VP39 heterodimer catalyzes the formation of poly(A) tails several hundred nucleotides in length. Here, we describe the overexpression of the VP39 subunit, its purification to near homogeneity, and its ability to associate physically with VP55 and to stimulate polyadenylation. Although VP39 possessed no independent poly(A) polymerase activity, RNA primers with oligo(A) tails greater than 30 adenylates in length could be extended nearly 40-fold more rapidly in the presence of VP39. VP39 enhanced the polyadenylation rate by converting the slow, nonprocessive polyadenylation occurring after the rapid burst in the presence of monomeric VP55, to a rapid, semiprocessive reaction. The effect of VP39 was dramatic when poly(A) primers were used as, 60 mM NaCl, VP39 enhanced the polyadenylation rate 500-fold, and at 90 mM NaCl VP39 was absolutely required. Nevertheless, the VP39-containing polymerase remained selective for polyadenylation of an mRNA 3'-end in the presence of excess poly(A). These data suggest that the role of VP39 in polyadenylation is to increase the affinity of the polymerase for the growing poly(A) tail.
Determining Components of Series Resistance from Measurements on a Finished Cell (2006)

Detailed expressions are given for computing the components of series resistance for a cell with a common contact pattern of parallel, equally-spaced gridlines which are perpendicular to two or more busbars. Front busbars and gridlines, contact resistance, emitter sheet, substrate, back metal and back busbars are all considered. No detailed thickness profiles are needed for any feature, only basic lengths and separations along with four-point resistance measurements. Results are given for a two-bus 15 cm square multicrystalline silicon cell having an efficiency of 15.0%. The total series resistance is 1.04 Omega-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , dominated by the gridline contribution. The addition of a third busbar is calculated to result in an increase in FF of 0.018, corresponding to an increase of 0.36% in absolute efficiency. A method for providing a coarse map of pseudo contact resistance for a finished cell, using only a four-point probe, is also introduced
Single molecule analysis by surfaced-enhanced Raman scattering (2008)

Our main objective in this tutorial review is to provide insight into some of the questions surrounding single molecule detection (SMD) using surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS). Discovered thirty years ago, SERS is now a powerful analytical tool, strongly tied to plasmonics, a field that encompasses and profits from the optical enhancement found in nanostructures that support localized plasmon excitations. The spectrum of the single molecule carries the quantum fingerprints of the system modulated by the molecule-nanostructure interactions and the electronic resonances that may result under laser excitation. This information is embedded in vibrational band parameters. The dynamics and the molecular environment will affect the bandwidth of the observed Raman bands. In addition, the localized surface plasmon resonances (LSPR) empower the nanostructure with a number of optical properties that will also leave their mark on the observed inelastic scattering process. Therefore, controlling size, shape and the formation of the aggregation state (or fractality) of certain metallic nanostructures becomes a main task for experimental SERS/SERRS. This molecule-nanostructure coupling may, inevitably, lead to spectral fluctuations, increase photobleaching or photochemistry. An attempt is made here to guide the interpretation of this wealth of information when approaching the single molecule regime.
Pervasive functional translation of noncanonical human open reading frames (2020)

Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based screening strategy to identify hundreds of noncanonical CDSs that are essential for cellular growth and whose disruption elicits specific, robust transcriptomic and phenotypic changes in human cells. Functional characterization of the encoded microproteins reveals distinct cellular localizations, specific protein binding partners, and hundreds of microproteins that are presented by the human leukocyte antigen system. We find multiple microproteins encoded in upstream open reading frames, which form stable complexes with the main, canonical protein encoded on the same messenger RNA, thereby revealing the use of functional bicistronic operons in mammals. Together, our results point to a family of functional human microproteins that play critical and diverse cellular roles.
Silicon fusion bonding for pressure sensors (2003)

Two novel processes for fabricating silicon piezoresistive pressure sensors are presented. The chips described are used to demonstrate an important silicon/silicon bonding technique called silicon fusion bonding (SFB). Using this technique, single-crystal silicon wafers can be reliably bonded with near-perfect interfaces without the use of intermediate layers. Pressure transducers fabricated with SFB exhibit greatly improved performance over devices made with conventional processes. SFB is also applicable to many other microchemical structures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing. (2003)

Poly(ADP-ribose) polymerase (PARP-1) is an abundant nuclear protein with a high affinity for single- and double-strand DNA breaks. Its binding to strand breaks promotes catalysis of the covalent modification of nuclear proteins with poly(ADP-ribose) synthesised from NAD(+). PARP-1-knockout cells are extremely sensitive to alkylating agents, suggesting the involvement of PARP-1 in base excision repair; however, its role remains unclear. We investigated the dependence of base excision repair pathways on PARP-1 and NAD(+) using whole cell extracts derived from normal and PARP-1 deficient mouse cells and DNA substrates containing abasic sites. In normal extracts the rate of repair was highly dependent on NAD(+). We found that in the absence of NAD(+) repair was slowed down 4-6-fold after incision of the abasic site. We also established that in extracts from PARP-1 deficient mouse cells, repair of both regular and reduced abasic sites was increased with respect to normal extracts and was NAD(+)-independent, suggesting that in both short- and long-patch BER PARP-1 slows down, rather than stimulates, the repair reaction. Our data support the proposal that PARP-1 does not play a major role in catalysis of DNA damage processing via either base excision repair pathway.
COVID-SAFE: An IoT-Based System for Automated Health Monitoring and Surveillance in Post-Pandemic Life (2020)

In the early months of the COVID-19 pandemic with no designated cure or vaccine, the only way to break the infection chain is self-isolation and maintaining the physical distancing. In this article, we present a potential application of the Internet of Things (IoT) in healthcare and physical distance monitoring for pandemic situations. The proposed framework consists of three parts: a lightweight and low-cost IoT node, a smartphone application (app), and fog-based Machine Learning (ML) tools for data analysis and diagnosis. The IoT node tracks health parameters, including body temperature, cough rate, respiratory rate, and blood oxygen saturation, then updates the smartphone app to display the user health conditions. The app notifies the user to maintain a physical distance of 2 m (or 6 ft), which is a key factor in controlling virus spread. In addition, a Fuzzy Mamdani system (running at the fog server) considers the environmental risk and user health conditions to predict the risk of spreading infection in real time. The environmental risk conveys from the virtual zone concept and provides updated information for different places. Two scenarios are considered for the communication between the IoT node and fog server, 4G/5G/WiFi, or LoRa, which can be selected based on environmental constraints. The required energy usage and bandwidth (BW) are compared for various event scenarios. The COVID-SAFE framework can assist in minimizing the coronavirus exposure risk.
Sustained-release naltrexone: novel treatment for opioid dependence (2007)

The devastating costs of opioid abuse and dependence underscore the need for effective treatments for these disorders. At present, several different maintenance medications exist for treating opioid dependence, including methadone, buprenorphine and naltrexone. Of these, naltrexone is the only one that possesses no opioid agonist effects. Instead, naltrexone occupies opioid receptors and prevents or reverses the effects produced by opioid agonists. Despite its clear pharmacologic effectiveness, its clinical effectiveness in treating opioid dependence has been disappointing, primarily due to non-compliance with taking the medication. However, the recent availability of sustained-release formulations of naltrexone has renewed interest in this medication. The present paper describes the development of sustained-release naltrexone formulations and discusses the clinical issues associated with their use in treating opioid dependence.
Structure of the MTIP–MyoA complex, a key component of the malaria parasite invasion motor (2006)

The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.
The capacity optimality of beam steering in large millimeter wave MIMO systems (2012)

Millimeter wave (mmWave) systems must overcome the heavy attenuation at high frequency to support high-throughput wireless communication. The small wavelength in mmWave systems enables beamforming using large antenna arrays to combat path loss with large array gain. Beamforming in traditional microwave systems is often done at baseband for maximum flexibility. Such baseband processing requires a dedicated transceiver chain per antenna element. The high cost of radio frequency (RF) chains in mmWave systems, however, makes supporting each antenna with a dedicated RF chain expensive. This mismatch between the number of antennas and transceiver chains makes baseband processing infeasible; thus mmWave systems typically rely on a traditional approach known as beam steering which can be done at RF using inexpensive phase shifters. Unlike baseband precoding, however, traditional beam steering is not explicitly designed to achieve the capacity of the mmWave channel. In this paper, we consider both beamforming and multi-stream precoding in single user systems with large mmWave antenna arrays at both transmitter and receiver. Using a realistic channel model, we show that the unconstrained capacity-achieving precoding solutions converge to simple beam steering solutions. Therefore, in large mmWave systems, no rate loss is incurred by adopting the traditional lower-complexity solution.
Evidence for superconductivity in low-temperature–grown GaAs (1991)

Magnetic-field-modulated microwave absorption and dc susceptibility measurements have detected evidence for superconductivity in As-rich GaAs layers grown by molecular-beam epitaxy at low temperatures (LT-GaAs). The transition temperature from the normal to the superconducting phase is 10 K. Electron microscopy of these layers found a new, As-rich layered structure in LT-GaAs that is most likely the origin of the superconductivity.
Repeater insertion to minimise delay in coupled interconnects (2002)

Signalling over long interconnect is a dominant issue in electronic chip design in current technologies, with the device sizes getting smaller and smaller and the circuits becoming ever larger. Repeater insertion is a well established technique to minimise the propagation delay over long resistive interconnect. In deep sub-micron technologies, as the wires are spaced closer and closer together and signal rise and fall times go into the sub-nano second region, the coupling between interconnects assumes great significance. The resulting crosstalk has implications on the data throughput and on signal integrity. Depending on the data correlation on the coupled lines, the delay can either decrease or increase. In this paper we attempt to quantify the effect of worst-case capacitive crosstalk in parallel buses and look at how it affects repeater insertion in particular. We develop analytic expressions for the delay, buffer size and number that are suitable in a-priori timing analyses and signal integrity estimations. All equations are checked against a dynamic circuit simulator (SPECTRE).
The Synthesis of Coformycin from 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide (1986)

Abstract A convenient synthesis of cotormycin from commercially available 5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide is described.
The interrelationship of sexually transmitted diseases and HIV infection: implications for the control of both epidemics in Africa. (1991)

There is a high burden of sexually transmitted diseases (STDs) in many parts of Africa. As for HIV, the highest rates of STDs are found in urban men and women aged 15-35 years. STDs may be responsible for up to 17% of productive life years lost to disease in sub-Saharan urban populations. Despite this heavy burden of STDs, however, their diagnosis and treatment remain neglected by public health in most of the developing world. Many factors drive the epidemiology of STDs in Africa. The disproportionate number of men relative to women in many cities prompts many men in urban areas to have sex with a core group of prostitutes who facilitate the spread of STDs. In other cities, the frequent change of sex partners, economic factors, access to health services, lack of health education, health seeking behavior, and lack of political will play roles in the spread of STDs. Genital ulcer disease is also more frequent in Africa than in developed countries. The authors discuss the interactions between HIV and other STDs, the impact of HIV infection upon other STDs, the impact of the HIV/STD interactions upon the HIV and STD epidemics, and implications for STD and HIV control programs.
The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy (2011)

Interruption of suppressive highly active antiretroviral therapy (HAART) in HIV-infected patients leads to increased HIV replication and viral rebound in peripheral blood. Effects of therapy interruption on gut-associated lymphoid tissue (GALT) have not been well investigated. We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in GALT of three HIV-positive patients who initiated HAART during primary HIV infection but opted to interrupt therapy thereafter. Longitudinal viral sequence analysis revealed that a stable proviral reservoir was established in GALT during primary HIV infection that persisted through early HAART and post-therapy interruption. Proviral variants in GALT and peripheral blood mononuclear cells (PBMCs) displayed low levels of genomic diversity at all times. A rapid increase in viral loads with a modest decline of CD4(+) T cells in peripheral blood was observed, while gut mucosal CD4(+) T cell loss was severe following HAART interruption. This was accompanied by increased mucosal gene expression regulating interferon (IFN)-mediated antiviral responses and immune activation, a profile similar to those found in HAART-naive HIV-infected patients. Sequence analysis of rebound virus suggested that GALT was not the major contributor to the postinterruption plasma viremia nor were GALT HIV reservoirs rapidly replaced by HIV rebound variants. Our data suggest an early establishment and persistence of viral reservoirs in GALT with minimal diversity. Early detection of and therapy for HIV infection may be beneficial in controlling viral evolution and limiting establishment of diverse viral reservoirs in the mucosal compartment.