gebhart/patrepeval huggingface dataset:
Attention-Mechanism-Containing Neural Networks for High-Resolution Remote Sensing Image Classification (2018)

A deep neural network is suitable for remote sensing image pixel-wise classification because it effectively extracts features from the raw data. However, remote sensing images with higher spatial resolution exhibit smaller inter-class differences and greater intra-class differences; thus, feature extraction becomes more difficult. The attention mechanism, as a method that simulates the manner in which humans comprehend and perceive images, is useful for the quick and accurate acquisition of key features. In this study, we propose a novel neural network that incorporates two kinds of attention mechanisms in its mask and trunk branches; i.e., control gate (soft) and feedback attention mechanisms, respectively, based on the branches’ primary roles. Thus, a deep neural network can be equipped with an attention mechanism to perform pixel-wise classification for very high-resolution remote sensing (VHRRS) images. The control gate attention mechanism in the mask branch is utilized to build pixel-wise masks for feature maps, to assign different priorities to different locations on different channels for feature extraction recalibration, to apply stress to the effective features, and to weaken the influence of other profitless features. The feedback attention mechanism in the trunk branch allows for the retrieval of high-level semantic features. Hence, additional aids are provided for lower layers to re-weight the focus and to re-update higher-level feature extraction in a target-oriented manner. These two attention mechanisms are fused to form a neural network module. By stacking various modules with different-scale mask branches, the network utilizes different attention-aware features under different local spatial structures. The proposed method is tested on the VHRRS images from the BJ-02, GF-02, Geoeye, and Quickbird satellites, and the influence of the network structure and the rationality of the network design are discussed. Compared with other state-of-the-art methods, our proposed method achieves competitive accuracy, thereby proving its effectiveness.
Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths (2009)

Variations in more than 40 genetic loci can alter the risk for developing inflammatory bowel disease (IBD). However, the epidemiology of ulcerative colitis and Crohn’s disease suggest that a recent environmental change accounts for most of the disease risk. In this chapter we will introduce IBD and outline its dramatic rise in prevalence over the last 70 years. We will consider the effective eradication of helminths during this time period and the effects of helminths on immunity. We will review the current evidence that helminths induce regulatory immune circuits that suppress aberrant inflammation and may be useful clinically to treat immune-mediated disease.
The process of diffusion through a rubber membrane (1920)

Abstract The production of balloon and airship fabrics in large quantities during the war has raised many problems in connection with leakage of hydrogen through membranes. It is desirable to have more information about the process by which gas passes through such rubber membranes. In considering a rubber film, two alternatives have been suggested. One is that the chief obstacle to the passage of a gas is that provided by the material itself, and that the gas can pass the surfaces of the film quite readily. The other is that the chief obstacle is at the surface, the actual thickness of rubber having very little effect on the permeability.
Enzymatic Biodegradation of Hydrogels for Protein Delivery Targeted to the Small Intestine (2015)

Multiresponsive poly(methacrylic acid-co-N-vinylpyrrolidone) hydrogels were synthesized with biodegradable oligopeptide crosslinks. The oligopeptide crosslinks were incorporated using EDC-NHS zero-length links between the carboxylic acid groups of the polymer and free primary amines on the peptide. The reaction of the peptide was confirmed by primary amine assay and IR spectroscopy. The microgels exhibited pH-responsive swelling as well as enzyme-catalyzed degradation targeted by trypsin present in the small intestine, as demonstrated upon incubation with gastrointestinal fluids from rats. Relative turbidity was used to evaluate enzyme-catalyzed degradation as a function of time, and initial trypsin concentration controlled both the degradation mechanism as well as the extent of degradation. Trypsin activity was effectively extinguished by incubation at 70 °C, and both the microgels and degradation products posed no cytotoxic effect toward two different cell lines. The microgels demonstrated pH-dependent loading of the protein insulin for oral delivery to the small intestine.
Cancer Therapy with &#223;-Lapachone (2002)

Beta-lapachone is an ortho naphthoquinone, originally isolated from a tree whose extract has been used medicinally for centuries. Recent investigations suggest its potential application against numerous diseases. Its lethality at micromolar ( m) concentrations against a variety of cancer cells in culture indicates its potential against tumor growth. A few experiments with positive results have been performed that apply the compound to tumors growing in animals. Particularly promising is the remarkably powerful synergistic lethality between beta-lapachone and taxol against several tumor cell lines implanted into mice; the mice did not appear to be adversely affected. Enhanced lethality of X-rays and alkylating agents to tumor cells in culture was reported when beta-lapachone was applied during the recovery period, because of inhibition of DNA lesion repair. Clinical trials are still to be initiated. The detailed mechanism of cell death induced by beta-lapachone remains for investigation. DNA topoisomerase I was the first biochemical target of beta-lapachone to be discovered, although its role in cell death is not clear. A proposed mechanism of cell death is via activation of a futile cycling of the drug by the cytoplasmic two-electron reductase NAD(P) H: quinone oxidoreductase, also known as NQO1, DT-diaphorase and Xip3. Death of NQO1 expressing cells is prevented by the NQO1 inhibitor dicoumarol, and cells with low NQO1 are resistant. At higher drug concentrations the production of reactive oxygen species (ROS) appears to be responsible. Furthermore, this process is p53- and caspase- independent. Either apoptotic or necrotic cell death can result, as reported in various studies performed under differing conditions. Beta-lapachone is one of a few novel anticancer drugs currently under active investigation, and it shows promise for chemotherapy alone and especially in combinations.
Comparison of 3D finite element analysis derived stiffness and BMD to determine the failure load of the excised proximal femur (2009)

This ex vivo study demonstrates that 3D-FEXI derived from a conventional 2D radiographic image has the potential to significantly increase the accuracy of failure load assessment of the proximal femur compared with that currently achieved with BMD. This approach may be readily extended to routine clinical BMD images derived by dual energy X-ray absorptiometry.
An evaluation study of driver profiling fuzzy algorithms using smartphones (2013)

Profiling driving behavior has become a relevant aspect in fleet management, automotive insurance and eco-driving. Detecting inefficient or aggressive drivers can help reducing fleet degradation, insurance policy cost and fuel consumption. In this paper, we present a Fuzzy-Logic based driver scoring mechanism that uses smartphone sensing data, including accelerometers and GPS. In order to evaluate the proposed mechanism, we have collected traces from a testbed consisting in 20 vehicles equipped with an Android sensing application we have developed to this end. The results show that the proposed sensing variables using smartphones can be merged to provide each driver with a single score.
Cell proliferation and thymocyte subset reconstitution in sublethally irradiated mice: compared kinetics of endogenous and intrathymically transferred progenitors. (1989)

After sublethal (6 Gy) whole-body irradiation, the C57BL/Ba (Thy-1.1) murine thymus regenerated in two waves, on days 3-10 and 25-32, separated by a severe relapse. The second phase of depletion-reconstitution reproduced the first one, in a less synchronous manner. The depletion affected all cell subsets, but CD4+ CD8- cells decreased later than immature cells. Cell proliferation, measured by BrdUrd incorporation, started on day 3 after irradiation and concerned CD4- CD8-, CD4- CD8+, and CD4+ CD8+ cells, sequentially. CD4+ CD8- cells never represented a significant percentage of cycling cells. When irradiation was immediately followed by an intrathymic injection of 10(5) C57BL/Ka (Thy-1.2) bone marrow cells, the relapse in thymus reconstitution was no longer observed. Detected with anti-Thy-1.2 antibodies, donor cells started cycling on day 14 and showed only one wave of proliferation. In these chimeras, recipient thymocytes behave exactly like thymocytes of solely irradiated mice. Intrathymically transferred CD4- CD8- thymocytes (10(5] showed the same proliferation kinetics as endogenous cells, with a peak in number on day 10 but completely disappeared from the thymus on days 14-21. These data reflect maturational differences between intrathymic and bone marrow precursor cells and suggest different radiosensitivities not linked to proliferative status. The resting state of the thymus immigrants was shown by the absence of Thy-1 acquisition by bone marrow cells continuously labeled for 10 days with BrdUrd in vivo before intrathymic transfer. When such labeled bone marrow cells were injected in the thymus, only the minor BrdUrd- subset gave rise to Thy-1+ cells.
Thermodynamics of swelling. Preparation and application of some composite, monosized polymer particles (1985)

The thermodynamic equations describing the equilibrium swelling of polymer, oligomer and polymer/oligomer particles are reviewed. The phenomenon of phase separation during swelling is discussed. Methods for preparation of monodisperse composite particles are described and the particle composition is discussed in terms of various relevant parameters. It is shown that crosslinked polymer particles may swell by a core and shell mechan sm which may increase the rate of swelling in the second step as compared to non-crosslinked part cles. Biochemical and biomedical applications of different composite particles are described.
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index (2006)

Dysregulated cellular proliferation is a characteristic property of cancer. We show that, despite this fact, cancers maintain high amplitude, circadian rhythms in their growth, DNA synthesis, and mitosis. These patterns are accompanied by the daily traverse of BMAL-1 protein between the cytoplasm, where it is produced, and nucleus, where it influences timing of cancer cell proliferation. This core clock gene product gates cancer cell proliferation by coordinating clock-controlled proteins, thymidylate synthase [thymidylate synthase activity (TSA) cell DNA replication], WEE-1 (cell mitosis), and vascular endothelial growth factor (growth). 5-Fluorouracil (5-FU)-induced host bone marrow and gut toxicity and tumor shrinkage following administration at six equispaced times of day allowed determination of circadian relationships among tumor growth, relevant clock, and clock-controlled proteins and dependence of 5-FU target availability (TSA) in normal and cancer tissues and resultant 5-FU toxic-therapeutic index. The time of day (hours after lights on) of low TSA in each tissue and tumor is respectively associated with greatest toxicity to that tissue and greatest tumor shrinkage. 5-FU treatment near daily awakening results in least damage to bone marrow and gut, greatest antitumor effect, and best survival. This time of day is associated with maximum tumor nuclear BMAL-1 and total cell WEE-1 protein. The described chain of events, for the first time, links cancer cell clock proteins, cancer cell DNA synthesis, proliferation, TSA, and 5-FU toxic-therapeutic index, explaining the dependence of cancer outcome on circadian timing of 5-FU.
FXR: a target for cholestatic syndromes? (2006)

The nuclear farnesoid X receptor (FXR) plays a pivotal role in maintaining bile acid homeostasis by regulating key genes involved in bile acid synthesis, metabolism and transport, including CYP7A1, UGT2B4, BSEP, MDR3, MRP2, ASBT, I-BABP, NTCP and OSTalpha-OSTbeta in humans. Altered expression or malfunction of these genes has been described in patients with cholestatic liver diseases. This review examines the rationale for the use of FXR ligand therapy in various cholestatic liver disorders and includes potential concerns.
A laboratory study of soil stabilisation with an urea-formaldehyde resin (2002)

The aim of this paper is to present laboratory results on the effectiveness of a proprietary\nurea-formaldehyde (UF) resin as a soil stabiliser. The Indirect Tensile Strength (ITS) was\nused to characterise the soil stabilising properties of the resin. A brown shale gravel with an\nITS dry strength of 160 kPa was used as test soil. Treated samples were compacted at the\noptimum moisture content (OMC) of the soil (ca. 9,5%) using the Marshall apparatus. Dry\nstrength was evaluated after the samples were left to air-dry for 7 or 21 days. The wet\nstrength was determined following a 24-hour water-soak of the air-dried samples. In this\nsystem, cement and lime were ineffective soil stabilisers even at the 6% dosage level. In\ncontrast, the addition of 2% UF resin was sufficient to raise the dry strength to 340 kPa but\nwet strength was still poor. This problem was solved by a further addition of a suitable\nbitumen emulsion. At a 2% dosage it increased both the wet and dry strengths to ca. 450 kPa.\nUnconfined Compressive Strength (UCS) measurements on this as well as other soil types\nconfirmed the soil stabilisation utility of the UF resin. These tests also showed that the system\nperformed better in siliceous than in calcareous aggregates.
ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research. (2003)

The mapping of the human genome and the determination of corresponding gene functions, pathways, and biological mechanisms are driving the emergence of the new research fields of toxicogenomics and systems toxicology. Many technological advances such as microarrays are enabling this paradigm shift that indicates an unprecedented advancement in the methods of understanding the expression of toxicity at the molecular level. At the National Center for Toxicological Research (NCTR) of the U.S. Food and Drug Administration, core facilities for genomic, proteomic, and metabonomic technologies have been established that use standardized experimental procedures to support centerwide toxicogenomic research. Collectively, these facilities are continuously producing an unprecedented volume of data. NCTR plans to develop a toxicoinformatics integrated system (TIS) for the purpose of fully integrating genomic, proteomic, and metabonomic data with the data in public repositories as well as conventional (Italic)in vitro(/Italic) and (Italic)in vivo(/Italic) toxicology data. The TIS will enable data curation in accordance with standard ontology and provide or interface a rich collection of tools for data analysis and knowledge mining. In this article the design, practical issues, and functions of the TIS are discussed through presenting its prototype version, ArrayTrack, for the management and analysis of DNA microarray data. ArrayTrack is logically constructed of three linked components: a) a library (LIB) that mirrors critical data in public databases; b) a database (MicroarrayDB) that stores microarray experiment information that is Minimal Information About a Microarray Experiment (MIAME) compliant; and c) tools (TOOL) that operate on experimental and public data for knowledge discovery. Using ArrayTrack, we can select an analysis method from the TOOL and apply the method to selected microarray data stored in the MicroarrayDB; the analysis results can be linked directly to gene information in the LIB.
Abstract 16018: Genetic variation near HCRTR2 associates with dramatic improvement of heart function in patients with heart failure (2013)

Marco V. Perez, 2013 Finalist and Presenting Author
Digitizing the KSO white light images (2010)

From 1989 up to 2007 the Sun was observed at the Kanzelhohe Observatory in white light on photographic film material. The images are on transparent sheet films and are not available to the scientific community now. With a photo scanner for transparent film material the films are now scanned and then prepared for scientific use. The programs for post processing are already finished and as an output FITS and JPEG-files are produced. The scanning should be finished end of 2011 and the data should then be available via our homepage.
Influence of Mastitis on Properties of Milk. V. Total and Free Concentrations of Major Minerals in Skimmilk (1970)

The influence of mastitis on the total and unbound concentrations of eight minerals in skimmilk was investigated with individual quarter milk samples. Wisconsin Mastitis Test positive (WMT > 20 ram) samples contained approximately 9, 8, and 4% less total potassium, inorganic phosphorus, and calcium than corresponding negative (WMT < 10 ram) samples. The positive samples contained about 38, 22, 19, 8, and 6% more sodium, copper, iron, zinc, and magnesium. Similar changes in the relative concentrations of the eight minerals were observed in ultracentrifugates of the positive and negative samples. The positive samples had higher total and unbound calcium-inorganic phosphorus ratios.
Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiscovery of new non-phospholipid inhibitors of the secretory phospholipases A2Haydn G. Beaton, Colin Bennion, Stephen Connolly, Anthony R. Cook, Nigel P. Gensmantel, Catherine Hallam, Kim Hardy, Barbara Hitchin, Clive G. Jackson, and David H. RobinsonCite this: J. Med. Chem. 1994, 37, 5, 557–559Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/jm00031a001https://doi.org/10.1021/jm00031a001research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Osmotic shock of fertilized mouse ova (1992)

The effect of osmotic changes on fertilized mouse ova was studied by measuring their survival, defined as development into hatching blastocysts, after exposure to various concentrations of ethanediol (ethylene glycol). In addition, a Boyle-van't Hoff plot was derived from exposing ova to hypotonic and hypertonic solutions ranging from 0.1 to 2.8 osmol. Volume of ova was inversely proportional to osmolality over this range. Extrapolation of this relationship yielded a nonosmotic volume of the ova of 22.5%. Eighty-five per cent or more of the ova survived exposure to this wide range of concentrations and developed into blastocysts. The rate of development of ova exposed to anisotonic solutions was the same as that of controls. Ova underwent osmotic shock when abruptly diluted out of concentrated solutions of ethanediol with an isotonic solution. Their survival was highly dependent on the ethanediol concentration with which they had equilibrated before dilution, and the manner, rate and temperature of dilution. The longer the exposure to ethanediol the greater was the sensitivity of the ova to osmotic shock, reflecting permeation of ethanediol into the ova. Osmotic shock could be alleviated by dilution at a high temperature, and prevented by the use of sucrose as an osmotic buffer at 37 degrees C. Identification of the variables that influence osmotic shock of ova will be helpful in the systematic study of their cryopreservation.
Genetic variability of herpes simplex virus: development of a pathogenic variant during passaging of a nonpathogenic herpes simplex virus type 1 virus strain in mouse brain (1983)

Herpes simplex virus type 1 ANG (HSV-1 ANG) is originally nonpathogenic for inbred mice upon intraperitoneal intravenous, or intravaginal inoculation. In contrast, mice died of encephalitis within 4 to 5 days after intracerebral inoculation with this strain. HSV-1 ANG was serially passaged in mouse brains. In two independent series, peripherally pathogenic virus variants had developed and accumulated in the virus progeny after 12 to 15 intracerebral passages. In mixed infections both nonpathogenic and pathogenic viruses replicated at the primary site of infection and spread to various organs. However, only the pathogenic phenotype could be recovered from the spinal cord and the brain. Comparison of the restriction enzyme cleavage patterns of pathogenic ANG and nonpathogenic ANG virus DNAs revealed distinct alterations in the S-segment (US) sequences bounded by coordinates 0.953 and 0.958 in the prototype orientation and by coordinates 0.862 to 0.867 in the IS orientation of the viral genome. However, it is not known whether these alterations are physiologically relevant to the observed changes in pathogenicity. When coinjected intraperitoneally at 50 to 100-fold excess, the nonpathogenic HSV-1 ANG protected mice against its own pathogenic variant as well as against other pathogenic HSV-1 strains. Pathogenic HSV-1 ANG proved to be genetically and phenotypically stable for at least 25 serial passages in tissue culture at either high or low multiplicity of infection.