gebhart/patrepeval huggingface dataset:
Photooxidation of CH3Cl on TiO2(110) Single Crystal and Powdered TiO2 Surfaces (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotooxidation of CH3Cl on TiO2(110) Single Crystal and Powdered TiO2 SurfacesJason C. S. Wong, Amy Linsebigler, Guangquan Lu, Jingfu Fan, and John T. Jr. YatesCite this: J. Phys. Chem. 1995, 99, 1, 335–344Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://doi.org/10.1021/j100001a051Request reuse permissionsArticle Views603Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
Current status and future plans for digital map databases in Japan (1993)

The Japan Digital Road Map Association (JDRMA) was founded to establish the standards for digital road map (DRM) and to produce a DRM database in Japan. The JDRMA is now in the process of refining the database using 1/25,000 scale topographical maps. The JDRMA supplies users with an updated version of the database every year. Car navigation is currently the largest application of DRM. Police departments, fire departments, ambulance services, and taxi companies use location systems that use DRM. Significant application of DRM is expected to come in the future in the planning and research fields. Road sign checking system, traffic accident analysis system, road census reference system and logistics system are now being studied. As the applications expand, more advanced DRMs must be made available, To meet this requirement, development of more detailed and precise DRMs and linkage to dynamic information systems is being pursued.
Thermal conductivity of plastic foams (1983)

Abstract A simple equation enabling the prediction of the thermal conductivity of plastic foams, without the aid of adjustable parameters, is proposed. The equation is based on a recurrent method, previously developed, that showed reasonable agreement with experimental results. Ways of decreasing the thermal radiation contribution are shown. In particular, the influence of cell size, radiation transmission through solid membranes, and low‐emissivity boundary surfaces are analyzed. Errors involved in steady techniques of measuring the thermal conductivity associated with radiation are discussed.
Using Patient-Derived Gliomaspheres to Molecularly Characterize and Dissect Distinctive Traits of Isocitrate Dehydrogenase 1 Mutant Gliomas for Therapeutic Benefit (2016)

Author(s): Garrett, Matthew Clark | Advisor(s): Kornblum, Harley I | Abstract: Glioblastoma (GBM) is the most common and malignant primary brain tumor. Despite maximal therapy prognosis remains poor. In the preceding decade, histological methods of categorization have begun to give way to molecular and genetic methods. Most prominently, the IDH1 mutation, when found in glioblastoma correlates with a better prognosis than those glioblastomas in which the mutation is not found. It is not known why this correlation exists. The mutant IDH1 enzyme is able to reduce alpha-ketoglutarate to create extremely high levels of 2-hydroxyglutarate but the tumorigenic significance of this reaction is unknown. In this dissertation we use an extensive collection of IDH1mutant and IDH1wildtype patient-derived gliomaspheres to dissect genetic and metabolic differences that distinguish the IDH1mutant subgroup. We found that the IDH1mutant gliomas were readily identifiable by their slower growth and distinctive expression profile. However, pharmacologic and genetic inhibition of the IDH1mutant enzyme did not change this signature in fact it did not seem to have any effect on these cells other than to decrease the levels of 2-hydroxyglutarate. The expression profile of IDH1mutant cells showed a large set of down-regulated genes in comparison to IDH1wildtype cells. One of the few genes to be up-regulated was Olig2 which upon further study we revealed to be essential for growth and a regulator of other important genes such as Tet2. Further, Olig2 expression may be targetable by the histone deacetylase inhibitor (HDACi) class of drugs in particular valproic acid.When we subjected the expression profiles of IDH1mutant glioma cells to metabolic analysis we found that IDH1mutant cells were enriched for pathways involved in DNA repair following radiation while IDH1wildtype glioma cells were enriched for pathways involved in de novo DNA synthesis. Following these results we confirmed that IDH1mutant cells do show better recovery following radiation and IDH1wildtype cells show a greater utilization and dependence on the de novo pathway for DNA synthesis.Historically, glioblastoma has been defined based on histologic criteria and while two glioblastoma samples may contain two mutually exclusive lists of mutations they would be considered minor variants within the larger fairly homogenous class. It is now becoming clear constitute a distinct group of brain tumors with different characteristics, prognosis and response to therapy and thus need to studied separately from IDH1wildtype glioblastomas.
Coherent receiver for AIS satellite detection (2010)

AIS is a universal shipborne Automatic Identification System recently introduced for traffic monitoring and safety at sea. Ships exchange navigational information to identify and localize vessels in a short range to avoid collisions. AIS signals use Gaussian Minimum Shift Keying (GMSK) for transmission. There is a growing need to develop a system which provides global maritime surveillance in order to better handle hazardous cargo transports, to improve safety, and to counteract illegal operations and terrorism. The possibility of extending the system in space to detect ships at long distances from the shore is considered in this paper. Since AIS was not originally designed for space detection, two challenges arise: first, received signals have a large Doppler due to the speed of the satellite, and second, two or more signals from different ships can be received at the same time due to the large coverage of the satellite. In this paper, we proposed an innovative coherent demodulator based on the Maximum Likelihood Estimation (MLE) and a Viterbi decoder to receive AIS signals from space and handle the large Doppler frequency shift. The MLE is used efficiently to estimate the frequency and the channel response.
PPA-A precise, data driven component tool (1994)

This paper outlines the development of a data-driven, fine pitch component placement machine, PPA-A, which is an integrated robotic workcell developed for attaching fine pitch integrated circuit components to printed circuit boards. In particular, the objectives for the machine are reviewed, and an overview of the solution is given. Problems encountered during the development are discussed, and details of the algorithms developed to solve these problems are given. These problems relate to achieving very precise placement of components, and are solved by novel calibration and execution schemes.< <ETX>></ETX>
A high performance low temperature 0.3 mu m CMOS on SIMOX (2003)

It is shown that ultrathin SOI offers a device design advantage for operation of CMOS circuits at 77 K. The use of ultrathin SOI makes it possible to achieve low threshold at relatively high channel doping, which is necessary for reduction of short channel effects. Very-high-performance loaded NAND inverters (with delays of less than 100 ps at 2 V) were fabricated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
REHABILITATION GRANT (1968)

<i>To the Editor</i>.—I have received a news item from the University of California concerning the grant of $128,000 to the School of Dentistry at the University of California, San Francisco, for the rehabilitation of patients who have undergone head and neck surgery or irradiation for cancer. It is my opinion that the medical profession, in a way, has missed the point of its relationship to the dental profession. The dentists are looking in more mouths than we are, and many of them are trained far beyond the level of an amalgam filling. Their work in research about the jaw bones, the teeth, the oral cavity has gone unnoticed by the medical profession. It is inadequate on our part to believe that dentists are limited to the extraction of abscessed teeth or the filling of carious teeth. In my opinion there is no question about their need and their value
Differential Virological and Immunological Outcome of Severe Acute Respiratory Syndrome Coronavirus Infection in Susceptible and Resistant Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 (2009)

We previously reported that transgenic (Tg) mice expressing human angiotensin-converting enzyme 2 (hACE2), the receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), were highly susceptible to SARS-CoV infection, which resulted in the development of disease of various severity and even death in some lineages. In this study, we further characterized and compared the pathogeneses of SARS-CoV infection in two of the most stable Tg lineages, AC70 and AC22, representing those susceptible and resistant to the lethal SARS-CoV infection, respectively. The kinetics of virus replication and the inflammatory responses within the lungs and brains, as well as the clinical and pathological outcomes, were assessed in each lineage. In addition, we generated information on lymphocyte subsets and mitogen-mediated proliferation of splenocytes. We found that while both lineages were permissive to SARS-CoV infection, causing elevated secretion of many inflammatory mediators within the lungs and brains, viral infection appeared to be more intense in AC70 than in AC22 mice, especially in the brain. Moreover, such infection was accompanied by a more profound immune suppression in the former, as evidenced by the extensive loss of T cells, compromised responses to concanavalin A stimulation, and absence of inflammatory infiltrates within the brain. We also found that CD8(+) T cells were partially effective in attenuating the pathogenesis of SARS-CoV infection in lethality-resistant AC22 mice. Collectively, our data revealed a more intense viral infection and immunosuppression in AC70 mice than in AC22 mice, thereby providing us with an immunopathogenic basis for the fatal outcome of SARS-CoV infection in the AC70 mice.
Spatiotemporal Coherent Control of Lattice Vibrational Waves (2003)

We achieved automated optical control over coherent lattice responses that were both time- and position-dependent across macroscopic length scales. In our experiments, spatiotemporal femtosecond pulse shaping was used to generate excitation light fields that were directed toward distinct regions of crystalline samples, producing terahertz-frequency lattice vibrational waves that emanated outward from their multiple origins at lightlike speeds. Interferences among the waves resulted in fully specified far-field responses, including tilted, focusing, or amplified wavefronts. Generation and coherent amplification of terahertz traveling waves and terahertz phased-array generation also were demonstrated.
Effect of propanal and diacetyl on quantity of remaining double bonds of chemically cured BisGMA/TEGDMA resins (1996)

The aim of the present study was to determine the effect of propanal and diacetyl addition on the quantity of remaining double bonds of chemically cured dental resins. Propanal (propionaldehyde) or diacetyl (2,3-butanedione) was added to monomer mixtures, which were then made chemically curable. The monomer mixtures were varied with respect to content of propanal or diacetyl. Addition of propanal or diacetyl to chemically curable resins resulted in a decrease in the quantity of remaining double bonds from 19.6% to 1.9% and from 19.6% to 11.4%, respectively. A negative correlation of statistical significance was found between content of propanal and quantity of remaining double bonds, while the relationship between content of diacetyl and quantity of remaining double bonds was found not to be linear. Propanal was equally effective in reducing the quantity of remaining double bonds in chemically cured and in the light cured resins studied previously. As regards diacetyl, a more pronounced effect on quantity of remaining double bonds was noted for light cured resins as compared with chemically cured resins. The most likely common reaction mechanism of propanal and diacetyl seemed to be that of chain transfer reactions. Furthermore, analysis of the data indicated a possible additional photoinitiating function of diacetyl.
Automatic Speaker Recognition Based on Pitch Contours (1969)

The results of a study aimed at finding the importance of pitch for automatic speaker recognition are presented. Pitch contours were obtained for 60 utterances, each approximately 2-sec in duration, of 10 female speakers. A data-reduction procedure based on the Karhunen-Loeve representation was found effective in representing the pitch information in each contour in a 20-dimensional space. The data were divided into two portions; one part was used to design the speaker recognition system, while the other part was used to test the effectiveness of the design. The 20-dimensional vectors representing the pitch contours of the design set were linearly transformed so that the ratio of interspeaker to intraspeaker variance in the transformed space was maximum. A reference utterance was formed for each speaker by averaging the transformed vectors of that speaker. The test utterance was assigned to the speaker corresponding to the reference utterance with the smallest Euclidean distance in the transformed space. The percentage of correct identifications using the above procedure was found to be 97%. The recognition rate increased to 98% with the addition of duration as an independent measure.
Expression of yeast L-A double-stranded RNA virus proteins produces derepressed replication: a ski- phenocopy (1991)

The plus strand of the L-A double-stranded RNA virus of Saccharomyces cerevisiae has two large open reading frames, ORF1, which encodes the major coat protein, and ORF2, which encodes a single-stranded RNA-binding protein having a sequence diagnostic of viral RNA-dependent RNA polymerases. ORF2 is expressed only as a Gag-Pol-type fusion protein with ORF1. We have constructed a plasmid which expresses these proteins from the yeast PGK1 promoter. We show that this plasmid can support the replication of the killer toxin-encoding M1 satellite virus in the absence of an L-A double-stranded RNA helper virus itself. This requires ORF2 expression, providing a potential in vivo assay for the RNA polymerase and single-stranded RNA-binding activities of the fusion protein determined by ORF2. ORF1 expression, like a host ski- mutation, can suppress the usual requirement of M1 for the MAK11, MAK18, and MAK27 genes and allow a defective L-A (L-A-E) to support M1 replication. These results suggest that expression of ORF1 from the vector makes the cell a ski- phenocopy. Indeed, expression of ORF1 in a wild-type killer makes it a superkiller, suggesting that a target of the SKI antiviral system may be the major coat protein.
New 2,2'‐Substituted 6,6'‐Dimethylbiphenyl Derivatives Inducing Strong Helical Twisting Power in Liquid Crystals (2005)

Abstract New optically active tetra‐ ortho ‐substituted biphenyl chiral dopants for nematic liquid crystals are described. It was shown, with respect to our previous results, that biphenyl chiral dopants bearing only mesogenic residues on their 2,2'‐positions and without any substituents on their 4,4'‐positions gave rise to very high twisting powers in nematic liquid crystals. This powerful and unconventional chiral dopant molecular architecture allowed the design of new tetra‐ ortho ‐substituted biphenyl derivatives, easier to prepare in optically active form. This simplification of the molecular architecture still affords chiral dopants for nematic liquid crystals with large helical twisting powers and allows more economical large‐scale preparation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
ANTICANCER ACTIVITY OF PYRIPLATIN, A MONOFUNCTIONAL CATIONIC PLATINUM(II) COMPOUND, IN HUMAN CANCER CELLS (2011)

Pyriplatin (cis-diammine(pyridine)chloroplatinum(II) or cDPCP), a platinum-based antitumor drug candidate, is a cationic compound with anticancer properties in mice and is a substrate for the organic cation transporters, hOCT1 and hOCT2, which facilitate oxaliplatin uptake. Unlike cisplatin and oxaliplatin, which form DNA cross-links, pyriplatin binds DNA in a monofunctional manner. The antiproliferative effects of pyriplatin, as well as combintions of pyriplatin with known anticancer drugs (paclitaxel, gemcitabine, SN38, cisplatin or 5-fluorouracil), were evaluated in a panel of epithelial cancer cell lines, with direct comparison to cisplatin and oxaliplatin. The effects of pyriplatin on gene expression and platinum-DNA adduct formation were also investigated. Pyriplatin exhibited cytotoxic effects against human cell lines after 24 h (IC50: 171 – 443 μM), with maximum cytotoxicity in HOP-62 non-small cell lung cancer cells after 72 h (IC50: 24 μM). Pyriplatin caused a G2/M block of cell cycle similar to that induced by cisplatin and oxaliplatin. Apoptotic cell death was supported by Annexin-V analysis and detection of phosphorylated H2AX and Chk2. Treatment with pyriplatin caused an increase in CDKN1/p21 and decrease in ERCC1 mRNA expression. On a platinum-per-nucleotide basis, pyriplatin adducts resulted in less cytotoxicity than cisplatin- and oxaliplatin-DNA adducts. The mRNA levels of several genes implicated in drug transport and repair of DNA damage, including MSH2 and GSTP1, correlate with pyriplatin cellular activity in our panel of cell lines. Synergy was observed in combinations of pyriplatin with paclitaxel. Because it has a different spectrum of activitythan that of cisplatin or oxaliplatin, pyriplatin may be regarded as a lead compound for the development of other drug candidates with cytotoxicity profiles that differ from those of the drugs currently in use.
Defining control strategies for analysing microgrids islanded operation (2005)

The main objective of this paper is to present the development of microsource modelling and the definition of control strategies to be adopted to evaluate the feasibility of operation of a microgrid when it becomes isolated. Normally, the microgrid operates in interconnected mode with the MV network, however scheduled or forced isolation can take place. In such conditions, the microgrid must have the ability to operate stably and autonomously. An evaluation of the need of storage devices and load-shedding strategies is included in the paper.
Ascorbic Acid: A Culture Requirement for Colony Formation by Mouse Plasmacytoma Cells (1971)

Plasmacytoma stem cells explanted from mice formed colonies in culture only in the presence of L-ascorbic acid; this vitamin was not needed for the formation of granulocytic colonies. Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively. Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.
Kinetic Study of Factor X During Oral Anticoagulation with Acenocoumarol: Potential Value for the Initiation of Treatment (1982)

Summary We measured prothrombin time and coagulation factors (F) VII and X in 19 patients under heparin treatment receiving acenocoumarol (3 mg per day) without a loading dose. Blood samples were obtained on the 1st (D0), 2nd (D1), 3d (D2), 5th (D4), 7th (D6) and 9th (D8) days of treatment. In 7 patients (group A) acenocoumarol dosage had to be reduced at D2, D4, or D6, based on a prothrombin time smaller than 25% of normal. In the remaining 12 patients (group B), FVII and prothrombin time followed a double exponential decline. Conversely, the FX decrease could be fitted to a single exponential pattern. The slope of the linear relation, loge (FX) = b - a (D), calculated from measurements made at D0, D1, and D2, allowed us to predict the FX level at D8 by simple extrapolation, and, consequently, to estimate as early as D2 whether a change of acenocoumarol dosage would have been required. In group A this extrapolation always announced a dangerously low FX concentration at Dg that justified the preventive reduction of acenocoumarol dosage. We conclude that FX can be a valuable guide in the initiation of an oral anticoagulant treatment.
Saying it with feeling: photonovels and comic books in development. (1986)

Advantages of photonovels and comic books to communicate developmental issues are described. These print media are stories told by means of drawings or photographs, with few words. The advantages of these media are their popularity, their ability to communicate cause and effect, symbols or analogies, emotional subjects. Readers like stories, identify with culturally appropriate and attractive characters, and retain messages well. Examples of popular themes that are effective are: comparisons of 2 families, sexual intrigues, and encounters with the supernatural. These materials may be expensive to produce, contain many more pages than a technical pamphlet, require skilled personnel for the design, and definitely must be pre-tested before the target audience. Although producing comics and photonovels is not easy, they are good media for presenting dramatic, emotional, and controversial issues along with the technical information contained.
Aggregation Behavior of Polystyrene/Poly(acrylic acid) Heteroarm Star Copolymers in 1,4-Dioxane and Aqueous Media (2001)

Ionic heteroarm star copolymers bearing polystyrene (PS) and poly(acrylic acid) (PAA) arms (PSnPAAn) were prepared by quantitative hydrolysis of the poly(tert-butyl acrylate) (PtBA) arms of the corresponding PSnPtBAn star copolymer. The aggregation properties of these copolymers were studied in various solvents. In 1,4-dioxane PS12PAA12 (with nearly symmetrical PS and PAA arms) forms reverse micelles of low aggregation number (Nagg) and spherical morphology. In an 80 : 20 (v/v) 1,4-dioxane/water mixture these micelles are transformed to regular micelles with an unexpectedly high Nagg and an elongated rod-like structure. An abnormal behavior was observed in aqueous solutions of charged PS24PANa24 (with asymmetrical PS and PAA arms, WPS = 19 wt.-%) at low concentrations. A non-equilibrium physical gel is formed, characterized by a very high viscosity and an elastic response upon oscillatory shearing.