gebhart/patrepeval huggingface dataset:
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts (2002)

In the present study, we investigated whether the mitogen-activated protein (MAP) kinase superfamily is involved in the bone morphogenetic protein (BMP)-4-stimulated synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells. BMP-4 dose-dependently stimulated osteocalcin synthesis. BMP-4 markedly induced the phosphorylation of p44/p42 MAP kinase and p38 MAP kinase, while having little effect on SAPK (stress-activated protein kinase)/JNK (c-Jun N terminal kinase) phosphorylation. SB203580 and PD169316, specific inhibitors of p38 MAP kinase, significantly reduced the osteocalcin synthesis stimulated by BMP-4. In contrast, PD98059 and U0126, inhibitors of upstream kinase of p44/p42 MAP kinase, markedly enhanced the BMP-4-stimulated osteocalcin synthesis. The BMP-4-induced phosphorylation of p44/p42 MAP kinase was suppressed by PD98059, which did not, however, affect the BMP-4-induced phosphorylation of p38 MAP kinase. Taken together, our results strongly suggest that p38 MAP kinase takes part in BMP-4-stimulated osteocalcin synthesis as a positive regulator in osteoblasts, whereas p44/p42 MAP kinase acts as a negative regulator in the synthesis. J. Cell. Biochem. 84: 583–589, 2002. © 2001 Wiley-Liss, Inc.
Photochemical Upconversion Enhanced Solar Cells: Effect of a Back Reflector (2012)

Photochemical upconversion is applied to a hydrogenated amorphous silicon solar cell in the presence of a back-scattering layer. A custom-synthesized porphyrin was utilized as the sensitizer species, with rubrene as the emitter. Under a bias of 24 suns, a peak external quantum efficiency (EQE) enhancement of ~2 % was observed at a wavelength of 720 nm. Without the scattering layer, the EQE enhancement was half this value, indicating that the effect of the back-scatterer is to double the efficacy of the upconverting device. The results represent an upconversion figure of merit of 3.5 × 10–4 mA cm–2 sun–2, which is the highest reported to date.
Abstract: Magnetic properties and domain structures in narrow NiFe stripes (1979)

A large increase in coercivity and a small increase in the magnetoresistive effect, accompanying narrowing of stripes of Ni-Fe films and decreasing film thickness, may be due to magnetization buckling perpendicular to the stripe length. Undesirable magnetic behavior may accompany decrease in size of Ni-Fe magnetic bubble and recording head devices. (AIP)
Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient? (2009)

With the emerging obesity pandemic, identifying those who appear to be protected from adverse consequences such as type 2 diabetes and certain malignancies will become important. We propose that the circulating immune system plays a role in the development of these comorbidities. Clinical data and blood samples were collected from 52 patients with severe obesity attending a hospital weight-management clinic and 11 lean healthy controls. Patients were classified into metabolically "healthy obese" (n = 26; mean age 42.6 years, mean BMI 46.8 kg/m(2)) or "unhealthy obese" (n = 26; mean age 45 years, mean BMI 47.5 kg/m(2)) groups, based upon standard cutoff points for blood pressure, lipid profile, and fasting glucose. Circulating lymphoid populations and phenotypes were assessed by flow cytometry. Obese patients had significantly less circulating natural killer (NK) and cytotoxic T lymphocytes (CTL) compared to lean controls. There were significantly higher levels of NK cells and CTLs in the healthy obese group compared to the unhealthy obese group (NK: 11.7% vs. 6.5%, P < 0.0001, CD8 13.4% vs. 9.3%, P = 0.04), independent of age and BMI and these NK cells were also less activated in the healthy compared to the unhealthy group (CD69, 4.1% vs. 11.8%, P = 0.03). This is the first time that quantitative differences in the circulating immune system of obese patients with similar BMI but different metabolic profiles have been described. The significantly higher levels of CTLs and NK cells, which express fewer inhibitory molecules, could protect against malignancy, infection, and metabolic disease seen in obesity.
Solar-Blind UV Photodetectors Based on GaN/AlGaN p-i-n Photodiodes (2000)

We report on the fabrication and characterization of n-Al 0.44 Ga 0.56 N/i-Al 0.44 Ga 0.56 N/p-GaN ultraviolet solar-blind photodetectors. The diodes were fabricated by organometallic vapor phase epitaxy on low-defect-density AlGaN layers using a low-temperature interlayer technique. They present a long cutoff wavelength at 270 nm with high rejection of solar light and a responsivity of 12 mA/W. Low dark currents between 4 and 35 pA/mm 2 at -5 V have been measured. A photocurrent decay time of 14 µs has been estimated in unbiased diodes. Due to the large dynamic resistance of the diode at 0 V bias, the detector itself shows a detectivity of 1.2×10 13 cm·Hz 1/2 ·W -1 .
A parabolic cylinder antenna with very low sidelobes (1980)

A method for designing an offset-fed parabolic cylinder antenna which has sidelobes of -50 dB or less over a 15-percent frequency band is presented. The designed antenna was built and tested, and shown to have approximately -46-dB sidelobes, although over a slightly different band than designed for.
Design methodologies and architecture solutions for high-performance interconnects (2004)

In deep sub-micron (DSM) technologies, interconnects play a crucial role in the correct functionality and largely impact the performance of complex system-on-chip (SoC) designs. For technologies of 0.25 /spl mu/m and below, wiring capacitance dominates gate capacitance, thus rapidly increasing the interconnect-induced delay. Moreover, the coupling capacitance becomes a significant portion of the on-chip total wiring capacitance, and coupling between adjacent wires cannot be considered as a second-order effect any longer. As a consequence, the traditional top-down design methodology is ineffective, since the actual wiring delays can be computed only after layout parasitic extraction, when the physical design is completed. Fixing all the timing violations often requires several time-consuming iterations of logical and physical design, and it is essentially a trial-and-error approach. Increasingly tighter time-to-market requirements dictate that interconnect parasitics must be taken into account during all phases of the design flow, at different level of abstractions. However, given the aggressive technology scaling trends and the growing design complexity, this approach is only temporarily ameliorate the interconnect problem. We believe that in order to achieve gigascale designs in the nanometer regime, a novel design paradigm, based on new forms of regularity and newly created IP (intellectual property) blocks must be developed, to provide a direct path from system-level architectural exploration to physical implementation.
Phase behavior of polystyrene, poly(2,6-dimethyl-1,4-phenylene oxide), and their brominated derivatives (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase behavior of polystyrene, poly(2,6-dimethyl-1,4-phenylene oxide), and their brominated derivativesRoger P. Kambour, John T. Bendler, and R. C. BoppCite this: Macromolecules 1983, 16, 5, 753–757Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/ma00239a010https://doi.org/10.1021/ma00239a010research-articleACS PublicationsRequest reuse permissionsArticle Views965Altmetric-Citations454LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β <sub>2</sub> subunit of GABA <sub>A</sub> receptors? (2013)

NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein coupled receptors GPR18 and GPR92. Recently, we have described that NA-glycine can also modulate recombinant α1β2γ2 GABAA receptors. Here we characterize in more detail this modulation and investigate the relationship of its binding site with that of the endocannabinoid 2-AG.
Submandible Angle in Nonobese Patients with Difficult Tracheal Intubation (2007)

Increased submandible angle characterizes craniofacial features of patients with DTI.
ReStore: Symptom Based Soft Error Detection in Microprocessors (2005)

Device scaling and large scale integration have led to growing concerns about soft errors in microprocessors. To date, in all but the most demanding applications, implementing parity and ECC for caches and other large, regular SRAM structures have been sufficient to stem the growing soft error tide. This will not be the case for long, and questions remain as to the best way to detect and recover from soft errors in the remainder of the processor - in particular, the less structured execution core. In this work, we propose the ReStore architecture, which leverages existing performance enhancing checkpointing hardware to recover from soft error events in a low cost fashion. Error detection in the ReStore architecture is novel: symptoms that hint at the presence of soft errors trigger restoration of a previous checkpoint. Example symptoms include exceptions, control flow mis-speculations, and cache or translation look-aside buffer misses. Compared to conventional soft error detection via full replication, the ReStore framework incurs little overhead, but sacrifices some amount of error coverage. These attributes make it an ideal means to provide very cost effective error coverage for processor applications that can tolerate a nonzero, but small, soft error failure rate. Our evaluation of an example ReStore implementation exhibits a 2x increase in MTBE (mean time between failures) over a standard pipeline with minimal hardware and performance overheads. The MTBF increases by 7x if ReStore is coupled with parity protection for certain pipeline structures.
Signal transduction between red cells and other blood cells (1995)

Journal Article Signal transduction between red cells and other blood cells Get access Philip S. Low, Philip S. Low Purdue University, West Lafayette, IN Search for other works by this author on: Oxford Academic Google Scholar Qing Li, Qing Li Purdue University, West Lafayette, IN Search for other works by this author on: Oxford Academic Google Scholar Anatoly Kiyatkin, Anatoly Kiyatkin Purdue University, West Lafayette, IN Search for other works by this author on: Oxford Academic Google Scholar Prema Rathinavelu, Prema Rathinavelu Purdue University, West Lafayette, IN Search for other works by this author on: Oxford Academic Google Scholar Robert L. Geahlen, Robert L. Geahlen Purdue University, West Lafayette, IN Search for other works by this author on: Oxford Academic Google Scholar Marietta L. Harrison Marietta L. Harrison Purdue University, West Lafayette, IN Search for other works by this author on: Oxford Academic Google Scholar Stem Cells, Volume 13, Issue 1, January 1995, Pages 90–91, https://doi.org/10.1002/stem.5530130116 Published: 01 January 1996
Optimization Of Phase‐Reversal Travelling‐Wave Optical Modulators (1989)

Abstract This paper presents an approach to optimizing the number and positions of phase reversal according to frequency band, active length and electrode characteristics. This method is more effective than the others. It can be applied to the design of not only low‐pass modulators but also bandpass devices for both frequency‐domain and time‐domain applications.
Benzalkonium Chloride and Glaucoma (2013)

Glaucoma patients routinely take multiple medications, with multiple daily doses, for years or even decades. Benzalkonium chloride (BAK) is the most common preservative in glaucoma medications. BAK has been detected in the trabecular meshwork (TM), corneal endothelium, lens, and retina after topical drop installation and may accumulate in those tissues. There is evidence that BAK causes corneal and conjunctival toxicity, including cell loss, disruption of tight junctions, apoptosis and preapoptosis, cytoskeleton changes, and immunoinflammatory reactions. These same effects have been reported in cultured human TM cells exposed to concentrations of BAK found in common glaucoma drugs and in the TM of primary open-angle glaucoma donor eyes. It is possible that a relationship exists between chronic exposure to BAK and glaucoma. The hypothesis that BAK causes/worsens glaucoma is being tested experimentally in an animal model that closely reflects human physiology.
Propane σ‐Complexes on PdO(101): Spectroscopic Evidence of the Selective Coordination and Activation of Primary CH Bonds (2015)

Achieving selective C-H bond cleavage is critical for developing catalytic processes that transform small alkanes to value-added products. The present study clarifies the molecular-level origin for an exceptionally strong preference for propane to dissociate on the crystalline PdO(101) surface via primary C-H bond cleavage. Using reflection absorption infrared spectroscopy (RAIRS) and density functional theory (DFT) calculations, we show that adsorbed propane σ-complexes preferentially adopt geometries on PdO(101) in which only primary C-H bonds datively interact with the surface Pd atoms at low propane coverages and are thus activated under typical catalytic reaction conditions. We show that a propane molecule achieves maximum stability on PdO(101) by adopting a bidentate geometry in which a H-Pd dative bond forms at each CH3 group. These results demonstrate that structural registry between the molecule and surface can strongly influence the selectivity of a metal oxide surface in activating alkane C-H bonds.
[Cause of leaf yellowing of Amomum villosum Lour. from Yunnan and its prevention]. (1993)

The results of the experiment showed that manganese deficiency in soil is one of the main causes of leaf yellowing of Amomum villosum and applying trace element fertilizer can make up deficiency. Manganese sulphate can effectively prevent the leaf yellowing.
CONTROL OF CLOSTRIDIUM BOTULINUM AND STAPHYLOCOCCUS AUREUS IN SEMI-PRESERVED MEAT PRODUCTS (1972)

Clostridium botulinum and Staphylococcus aureus are naturally occurring contaminants in semi-preserved meat products. They can be inhibited by (a) storage below 3 C, (b) 10% sodium chloride (brine concentration), (c) pH values below 4.5, or (d) proper combinations of these factors. However, most meat products do not have the pH values and brine concentrations required to completely inhibit C. botulinum and S. aureus and there is always a risk of temperature abuse. Improved safety can be achieved by adding 1% or more glucose to the product. The glucose will, in the event of temperature abuse, generally be fermented to lactic acid by the indigenous microflora in the product. As a result, the pH value drops to a level at which the brine concentration is sufficient to inhibit C. botulinum and S. aureus. A better approach to safety is to add, together with glucose, a radiation-killed preparation of lactic acid bacteria, e.g., Pediococcus cerevisiae. Such preparations cause a rapid decline in pH only when the product is exposed to a high temperature, and they are stable during storage of meat products. Addition of irradiated lactic acid bacteria to meat products has not yet been officially approved. Another way to improve the safety of semi-preserved meat is to add sufficient glucono-delta-lactone to reduce the initial pH of the product to a level at which the salt concentration is inhibitory. Use of larger amounts of glucono-delta-lactone may result in flavor and color problems even when the meat product is kept at refrigeration temperatures.
A Hybrid Optical-Digital Method For The Determination Of The Optical Transfer Function Of The Human Eye. (1987)

Aerial short term retinal images of a point source are recorded with a TV camera and feeded into a Digital Image Processing system that allows to determine and display the bidimensional Point Spread Function and Optical Transfer Function of human eyes.
A Fusion Protein Vaccine Containing OprF Epitope 8, OprI, and Type A and B Flagellins Promotes Enhanced Clearance of Nonmucoid <i>Pseudomonas aeruginosa</i> (2009)

Although chronic Pseudomonas aeruginosa infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients, there is no approved vaccine for human use against P. aeruginosa. The goal of this study was to establish whether a multivalent vaccine containing P. aeruginosa type A and B flagellins as well as the outer membrane proteins OprF and OprI would promote enhanced clearance of P. aeruginosa. Intramuscular immunization with flagellins and OprI (separate) or OprI-flagellin fusion proteins generated significant antiflagellin immunoglobulin G (IgG) responses. However, only the fusions of OprI with type A and type B flagellins generated OprI-specific IgG. Immunization with a combination of OprF epitope 8 (OprF(311-341)), OprI, and flagellins elicited high-affinity IgG antibodies specific to flagellins, OprI, and OprF that individually promoted extensive deposition of C3 on P. aeruginosa. Although these antibodies exhibited potent antibody-dependent complement-mediated killing of nonmucoid bacteria, they were significantly less effective with mucoid isolates. Mice immunized with the OprF(311-341)-OprI-flagellin fusion had a significantly lower bacterial burden three days postchallenge and cleared the infection significantly faster than control mice. In addition, mice immunized with the OprF(311-341)-OprI-flagellin fusion had significantly less inflammation and lung damage throughout the infection than OprF-OprI-immunized mice. Based on our results, OprF(311-341)-OprI-flagellin fusion proteins have substantial potential as components of a vaccine against nonmucoid P. aeruginosa, which appears to be the phenotype of the bacterium that initially colonizes CF patients.
Prologue (2019)

Abstract When liberal satirist Samantha Bee and conservative outrage host Glenn Beck appeared on Bee’s program in 2016 to discuss the ways their political rhetoric might be similar, it provided an opportunity to think about how some the functions and outcomes of the genres of liberal satire and conservative opinion (outrage) may overlap. This chapter describes this conversation between the two show hosts and uses it as a springboard for the book. The chapter introduces the two questions at the heart of this book: Why is political satire so liberal? Why do liberals seem unsuccessful at talk radio and outrage programming? The chapter also chronicles how and why the author came to ask these questions and summarizes the remaining chapters of the book, providing a roadmap for readers.
New sheath for vascular access and subcutaneous drug administration: Multicenter clinical trial for pain prevention after cardiac catheterization (1997)

A new vascular sheath design (anesthesia infusion sleeve, or AIS) was developed to enable administration of local anesthetics or other medications into the subcutaneous tissue around an arterial or venous insertion site without any additional needle sticks or manipulation. Design, animal testing, and an initial small single-site clinical study have previously been published. The current study was multicenter and randomized 80 patients to use of a standard sheath for vascular access or the AIS. Pain associated with sheath placement, postprocedure pain, and pain associated with sheath removal before and during manual compression was recorded. Baseline pain was identical in both the standard and AIS groups. Pain during infiltration and with initial femoral artery compression was significantly lower in the AIS group. A quality of life questionnaire indicated that the AIS sheath was associated with less discomfort and was preferred over a standard sheath in patients who had had a previous procedure performed. The AIS represents a simple addition to standard sheath design, offering superior pain control during removal compared to the standard technique, without the need for systemic analgesics or additional needle punctures.
Pharmacology and Experimental Therapeutics: A Survey for 1941-1946 (1948)

The title of this book is somewhat misleading. The subject matter consists of brief abstracts of toxicologic and therapeutic information gleaned from the medical literature published during and subsequent to World War II. The drugs are arranged alphabetically, and only those which were subject to investigation during the period covered by the survey are included. Fortunately many of the older drugs were reinvestigated during the war years, and thus the volume contains information not only on the new synthetic chemicals but on many of the well known older agents. This book is useful only when consulted in conjunction with other reference works on pharmacology and therapeutics. It may be considered as an appendix to the more extensive standard works, and as such will provide up-to-date information on recent investigations on drugs. The emphasis has been placed on quantitative toxicologic data, although metabolic and pharmacodynamic effects of the various drugs are
Using Self-Contradiction to Learn Confidence Measures in Stereo Vision (2016)

Learned confidence measures gain increasing importance for outlier removal and quality improvement in stereo vision. However, acquiring the necessary training data is typically a tedious and time consuming task that involves manual interaction, active sensing devices and/or synthetic scenes. To overcome this problem, we propose a new, flexible, and scalable way for generating training data that only requires a set of stereo images as input. The key idea of our approach is to use different view points for reasoning about contradictions and consistencies between multiple depth maps generated with the same stereo algorithm. This enables us to generate a huge amount of training data in a fully automated manner. Among other experiments, we demonstrate the potential of our approach by boosting the performance of three learned confidence measures on the KITTI2012 dataset by simply training them on a vast amount of automatically generated training data rather than a limited amount of laser ground truth data.