gebhart/patrepeval huggingface dataset:
Some New Parallel Mechanisms Containing the Planar Four-Bar Parallelogram (2003)

A parallelogram allows the output link to remain at a fixed orientation with respect to an input link, for which it acts as a unique role in the design of parallel mechanisms. In this paper, the unique role of a parallelogram is used completely to design some new parallel mechanisms with two to six degrees of freedom (DoFs). In these mechanisms, some with three DoFs possess the advantage of very high rotational capability and some with two DoFs have the translational output of a rigid body. More than that, the design concept is also applied first to some parallel mechanisms to improve the systems' rotational capability. The parallel mechanisms proposed in this paper have wide applications in industrial robots, simulators, micromanipulators, parallel kinematics machines, and any other manipulation devices in which high rotational capability and stiffness are needed. Especially, the paper provides new concepts of the design of novel parallel mechanisms and the improvement of rotational capability for such systems.
Pharmacological advances in the treatment of neuro-otological and eye movement disorders (2006)

Although progress has been made in the treatment of vestibular neuritis, downbeat and upbeat nystagmus, as well as EA2, state-of-the-art trials must still be performed on many vestibular and ocular motor disorders, namely Ménière's disease, bilateral vestibulopathy, vestibular paroxysmia, vestibular migraine, and many forms of central eye movement disorders.
Laser‐assisted endocardiectomy for refractory ventricular tachyarrhythmias: preliminaRy intraoperative experience (1987)

Previous in vitro investigations utilizing necropsy specimens have suggested a potential role for laser irradiation in the treatment of refractory ventricular tachyarrhythmias associated with pathologically thickened endocardium. In the patient described in the present report, findings of these previous in vitro studies were applied intraoperatively to a patient undergoing surgery for ischemic heart disease associated with ventricular tachyarrhythmias. Aneurysm resection and manual subendocardial resection were performed using standard techniques. Laser irradiation was used to ablate pathologically thickened endocardium involving the papillary muscle and thereby avoid mitral valve replacement. Postoperatively, there was no auscultatory evidence of mitral regurgitation, and ventricular tachycardia could not be induced by electrophysiologic provocative testing. This preliminary experience confirms that laser irradiation is both a feasible and potentially advantageous means of accomplishing endocardial debridement in patients undergoing arrhythmia-ablation procedures.
<i>Q</i>-Switching and Cavity Dumping of Nd:YAlG Lasers (1971)

Experiments in Q-switching and cavity dumping of a Nd:YAlG laser have been carried out. The system in either case is composed of a Nd:YAlG folded cavity laser and an intracavity acousto-optic modulator made of fused silica and Brewster cut. Q-switching is achieved by first feeding the modulator with an acoustic pulse of sufficient duration and intensity to keep the laser below threshold (hold off pulse). Termination of the acoustic pulse allows the power inside the laser cavity to build up. A second short acoustic pulse, introduced to the modulator at the time when the internal energy reaches its maximum, couples the energy out of the cavity. This pulse may also be the beginning of the hold off pulse. Cavity dumping is accomplished by feeding the modulator with short acoustic pulses at fixed intervals. In the Q switching mode the system can operate with a maximum repetition rate of about 30 kHz. In the cavity dumping mode of operation the repetition rate of the light pulses can be controlled from 125 kHz to several MHz. The minimum pulse duration obtained in both modes of operation was about 80 nsec. The average power can reach 2 W, which is the maximum cw power capability of the laser used.
Experimental Determination of the Disproportionation of Hydrogen Isotopes in Water (1966)

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Properties of integral membrane protein structures: Derivation of an implicit membrane potential (2005)

Distributions of each amino acid in the trans-membrane domain were calculated as a function of the membrane normal using all currently available alpha-helical membrane protein structures with resolutions better than 4 A. The results were compared with previous sequence- and structure-based analyses. Calculation of the average hydrophobicity along the membrane normal demonstrated that the protein surface in the membrane domain is in fact much more hydrophobic than the protein core. While hydrophobic residues dominate the membrane domain, the interfacial regions of membrane proteins were found to be abundant in the small residues glycine, alanine, and serine, consistent with previous studies on membrane protein packing. Charged residues displayed nonsymmetric distributions with a preference for the intracellular interface. This effect was more prominent for Arg and Lys resulting in a direct confirmation of the positive inside rule. Potentials of mean force along the membrane normal were derived for each amino acid by fitting Gaussian functions to the residue distributions. The individual potentials agree well with experimental and theoretical considerations. The resulting implicit membrane potential was tested on various membrane proteins as well as single trans-membrane alpha-helices. All membrane proteins were found to be at an energy minimum when correctly inserted into the membrane. For alpha-helices both interfacial (i.e. surface bound) and inserted configurations were found to correspond to energy minima. The results demonstrate that the use of trans-membrane amino acid distributions to derive an implicit membrane representation yields meaningful residue potentials.
Ultrathin Spinel‐Structured Nanosheets Rich in Oxygen Deficiencies for Enhanced Electrocatalytic Water Oxidation (2015)

Electrochemical water splitting is a clean technology for H2 fuels, but greatly hindered by the slow kinetics of the oxygen evolution reaction (OER). Herein, a series of spinel-structured nanosheets with oxygen deficiencies and ultrathin thicknesses were designed to increase the reactivity and the number of active sites of the catalysts, which were then taken as an excellent platform for promoting the water oxidation process. Theoretical investigations showed that the oxygen vacancies confined in the ultrathin nanosheet could lower the adsorption energy of H2O, leading to increased OER efficiency. As expected, the NiCo2O4 ultrathin nanosheets rich in oxygen vacancies exhibited a large current density of 285 mA cm(-2) at 0.8 V and a small overpotential of 0.32 V, both of which are superior to the corresponding values of bulk samples or samples with few oxygen deficiencies and even higher than those of most reported non-precious-metal catalysts. This work should provide a new pathway for the design of advanced OER catalysts.
A hybrid system for fraud detection in mobile communications. (1999)

During the course of the European project \Advanced Security for Personal Communication Technologies (ASPeCT), we have developed some rule-based and neural network architectures as a number of di erent fraud detection tools for GSM networks. We have now integrated these di erent techniques into a hybrid detection tool. We optimized the performance of the hybrid system in terms of the number of subscribers raising alarms. More precisely, we optimized performance curves showing the trade-o between the percentage of correctly identi ed fraudsters versus the percentage of new subscribers raising alarms. We report here on a common suite of experiments we performed on these di erent sys-
Engineered microenvironments for human stem cells (2008)

Regulation of cell differentiation and assembly remains a fundamental question in developmental biology. During development, tissues emerge from coordinated sequences of the renewal, differentiation, and assembly of stem cells. Likewise, regeneration of an adult tissue is driven by the migration and differentiation of repair cells. The fields of stem cells and regenerative medicine are starting to realize how important is the entire context of the cell environment, with the presence of other cells, three-dimensional matrices, and sequences of molecular and physical morphogens. The premise is that to unlock the full potential of stem cells, at least some aspects of the dynamic environments normally present in vivo need to be reconstructed in experimental systems used in vitro. We review here some recent work that utilized engineered environments for guiding the embryonic and adult human stem cells, and focus on vasculogenesis as a critical and universally important aspect of tissue development and regeneration. Birth Defects Research (Part C) 84:335-347, 2008. (c) 2008 Wiley-Liss, Inc.
Clinical implications of the new definition of myocardial infarction (2003)

yocardial infarction (MI) can be considered from several perspectives: clinical, electrocardiographic, biochemical, pathological, epidemiological, and imaging. The diagnosis of MI has psychological, social, and legal implications. MI is often used as a major end point in clinical trials.
Nutritional Supplements: Amino Acids and their Derivatives (2003)

PROLOGUE This manuscript describes the contents of the topic Supplements: Amino Acid and their Derivatives, that is part of an elective course Biochemical Cofactors and Nutritional Supplements (PH 470), offered to third professional year (P5) PharmD students. The course consists of three 50-minute sessions per week for a total of 42 sessions and 90 nutritional supplements including the common water-soluble and fat-soluble vitamins. Supplements for this topic and the course are chosen based on their popularity and availability on internet sites, in chain drug stores, and health-food retail outlets. The lectures are supplemented with e-mail submissions from assigned groups of students. Students are instructed to submit current information that fulfills the following criteria: (i) new developments about the basic biochemistry and pharmacology; (ii) claims not supported by adequate peerreviewed studies; (iii) adverse reactions with prescribed medications; and (iv) effects on major organs and tissues. The course also has an online component on WebCT. The instructor uses this website to post supplementary information and online quizzes. Students receive credit for completing four online quizzes during the semester.
Protein Inhibitor of Activated Signal Transducer and Activator of Transcription 1 Interacts with the N-Terminal Domain of Mineralocorticoid Receptor and Represses Its Transcriptional Activity: Implication of Small Ubiquitin-Related Modifier 1 Modification (2003)

Molecular mechanisms underlying mineralocorticoid receptor (MR)-mediated gene expression are not fully understood but seem to largely depend upon interactions with specific coregulators. To identify novel human MR (hMR) molecular partners, yeast two-hybrid screenings performed using the N-terminal domain as bait, allowed us to isolate protein inhibitor of activated signal transducer and activator of transcription (PIAS)1 and PIASxbeta, described as SUMO (small ubiquitin-related modifier) E3-ligases. Specific interaction between PIAS1 and hMR was confirmed by glutathione-S-transferase pull-down experiments and N-terminal subdomains responsible for physical contacts were delineated. Transient transfections demonstrated that PIAS1 is a corepressor of aldosterone-activated MR transactivation but has no significant effect on human glucocorticoid receptor transactivation. The agonist or antagonist nature of the bound ligand also determines PIAS1 corepressive action. We provided evidence that PIAS1 conjugated SUMO-1 to hMR both in vitro and in vivo. Deciphering the unique sumoylation pattern of hMR, which possesses five consensus SUMO-1 binding sites, by combinatorial lysine substitutions, revealed a major impact of sumoylation on hMR properties. Using a murine mammary tumor virus promoter, PIAS1 action was independent of sumoylation whereas with glucocorticoid response element promoter, PIAS1 corepressive action depended on hMR sumoylation status. Taken together, our results identify a novel function for PIAS1 which interacts with the N-terminal domain of hMR and represses its ligand-dependent transcriptional activity, at least in part, through SUMO modifications.
Estimation of Room Reflection Parameters for a Reverberant Spatial Audio Object (2015)

Estimating and parameterizing the early and late reflections of an enclosed space is an interesting topic in acoustics. With a suitable set of parameters, the current concept of a spatial audio object (SAO), which is typically limited to either direct (dry) sound or diffuse field components, could be extended to afford an editable spatial description of the room acoustics. In this paper we present an analysis/synthesis method for parameterizing a set of measured room impulse responses (RIRs). RIRs were recorded in a medium-sized auditorium, using a uniform circular array of microphones representing the perspective of a listener in the front row. During the analysis process, these RIRs were decomposed, in time, into three parts: the direct sound, the early reflections, and the late reflections. From the direct sound and early reflections, parameters were extracted for the length, amplitude, and direction of arrival (DOA) of the propagation paths by exploiting the dynamic programming projected phase-slope algorithm (DYPSA) and classical delay-and-sum beamformer (DSB). Their spectral envelope was calculated using linear predictive coding (LPC). Late reflections were modeled by frequency-dependent decays excited by band-limited Gaussian noise. The combination of these parameters for a given source position and the direct source signal represents the reverberant or “wet” spatial audio object. RIRs synthesized for a specified rendering and reproduction arrangement were convolved with dry sources to form reverberant components of the sound scene. The resulting signals demonstrated potential for these techniques, e.g., in SAO reproduction over a 22.2 surround sound system.
A Framework for Multi-Skills Inspectors Scheduling with Client Preferences in Service Industry: Real Case (2019)

Managing efficiently the human resources in service sector is proved to bring important benefits for both managers and workers, especially when employees are in direct contact with clients. This scheduling problem has proved to be a challenging task, even for managers and experienced planners, due to the multiplicity of factors that have to be taken into consideration. In this paper, the staff scheduling problem is formally described, and then we focus on the inspection sector aiming to introduce all the parameters and objectives directly related to inspection missions through semi-structured interviews conducted with managers and inspectors of an inspection company.
Operation of a mineral-recovery unit on brine from the Salton Sea known geothermal resource area (1982)

The Bureau of Mines operated a mineral recovery unit to recover metal values from post-flash geothermal brines from the Salton Sea known geothermal resource area as part of its research into the use of plentiful resources. The brine was available for metals recovery after its heat content had been used to generate electricity. The brine source was treated with lime to precipitate the contained iron, manganese, lead, and zinc before injection of the heat-depleted brine into the underground reservoir. Data are presented on the effects of process variables, such as rate and method of lime addition and air oxidation versus air exclusion. Variations in precipitation of metal values, composition of precipitates, effectiveness of slurry thickeners, and methods of treating the precipitates to recover metal values are discussed.
Surface-enhanced Raman spectroscopy using a silver-coated capillary substrate (1992)

A silver-coated capillary substrate has been prepared by means of chemical reduction of silver ions. Its performance as a surface-enhanced Raman scattering (SERS) active substrate has been compared with those of chemically prepared silver/glass and of silver islands using p- chlorobenzoic acid (PCBA) as an analyte. The adsorption behavior of PCBA on or near the surface of silver films has partially been characterized. The dependence of SERS intensity on the pH and the concentration of the analyte solution may be interpreted on the basis of chemical enhancement mechanism.
Use of sterile maggots to treat panniculitis in an aged donkey (2001)

An aged female donkey developed a severe, localised, suppurative panniculitis secondary to a skin wound. Bacterial culture of swabs taken from the wound gave a profuse growth of multi-drug-resistant Pseudomonas aeruginosa, a profuse growth of Escherichia coli and a moderate growth of beta-haemolytic Streptococcus species. The lesion did not respond to conventional medical and surgical treatment and continued to progress. Six applications of sterile larvae (maggots) of the common greenbottle, Lucilia sericata, were used to debride the wound successfully.
Intracellular Gold Nanoparticles Increase Neuronal Excitability and Aggravate Seizure Activity in the Mouse Brain (2014)

Due to their inert property, gold nanoparticles (AuNPs) have drawn considerable attention; their biological application has recently expanded to include nanomedicine and neuroscience. However, the effect of AuNPs on the bioelectrical properties of a single neuron remains unknown. Here we present the effect of AuNPs on a single neuron under physiological and pathological conditions in vitro. AuNPs were intracellularly applied to hippocampal CA1 neurons from the mouse brain. The electrophysiological property of CA1 neurons treated with 5- or 40-nm AuNPs was assessed using the whole-cell patch-clamp technique. Intracellular application of AuNPs increased both the number of action potentials (APs) and input resistance. The threshold and duration of APs and the after hyperpolarization (AHP) were decreased by the intracellular AuNPs. In addition, intracellular AuNPs elicited paroxysmal depolarizing shift-like firing patterns during sustained repetitive firings (SRF) induced by prolonged depolarization (10 sec). Furthermore, low Mg2+-induced epileptiform activity was aggravated by the intracellular AuNPs. In this study, we demonstrated that intracellular AuNPs alter the intrinsic properties of neurons toward increasing their excitability, and may have deleterious effects on neurons under pathological conditions, such as seizure. These results provide some considerable direction on application of AuNPs into central nervous system (CNS).
Cornelius Lanczos -- Discoveries in the Quantum and General Relativity Theories (2002)

Two of Lanczos' seminal contributions in physics that are not generally known about in the physics community are discussed and commented in relation to more recent investigations: First, his integral formulation of the Schroedinger equation that he published just before Schroedinger himself published his differential equation formulation of quantum mechanics, and, second, his solution to the problem of equations of motion of material particles in the theory of general relativity.
A t(1;19) chromosome translocation in three cases of human malignant melanoma. (1986)

Abnormalities of chromosome 1, including trisomy for all or a portion of the long arm, have been frequently reported in many cancers. Anomalies of chromosome 19 are far less common, although a t(1;19)(q23;p13) translocation has been reported in association with pre-B-cell leukemia. We have observed a t(1;19)(q12;p13) translocation in three cases of advanced melanoma, with the translocation chromosome representing an extra dose of 1q in each instance. The breakpoint on 1q was within the centromeric heterochromatin, proximal to the site in pre-B-cell leukemia, but the breakpoint on 19p appeared identical. The gene for human insulin receptor has recently been mapped to this region of chromosome 19 (p13.2-13.3). This gene shares structural and sequence homologies with the epidermal growth factor receptor (erb-B oncogene) and members of the src family of oncogenes, suggesting that alterations in the insulin receptor, resulting from chromosomal translocation, could lead to a role in tumorigenesis. The present findings may permit this possibility to be examined in a neoplasm of neuroectodermal origin.
A COMPARISON OF WATER TRAPS, CYLINDRICAL STICKY TRAPS AND SUCTION TRAPS FOR SAMPLING THYSANOPTERAN POPULATIONS AT DIFFERENT LEVELS (1959)

Thysanoptera drifting over and around a wheat field were trapped using black, green and white water traps, black cylindrical sticky traps and suction traps. Certain Taeniothrips spp., Thrips spp., and Aeolothrips spp. were strongly attracted to white but not to green or black; Limothrips cerealium Hal., Chirothrips manicatus Hal., and Stenothrips gramium Uzel were not markedly attracted to any of these colours. At crop level suction traps gave more consistent catches 2 ) than either sticky or water traps; at higher levels, catches from sticky traps were more consistent than those from water traps. Up to 48 ft the aerial density of all species decreased with height but the rapidity of the decrease differed between species.
Evaluation of inversion approaches for guided wave thickness mapping (2014)

Accurate inversion is vital for quantitative imaging, including ultrasonic guided wave tomography, where thickness maps of plate-like structures are reconstructed to quantify corrosion damage. The dispersive properties of guided waves are often exploited to enable thickness maps to be produced from wave speed reconstructions. Ray tomography, diffraction tomography and a hybrid algorithm combining their features were investigated to reconstruct wave speed. Test data produced from simple defects of different sizes using a realistic full elastic guided wave model and the equivalent idealized acoustic model were passed to the imaging algorithms, generating wave speed maps, and, from these, thickness maps. For both datasets, ray tomography exhibited poor resolution. Diffraction tomography performed better, but was limited to shallow, small defects. The hybrid algorithm achieved the best results, giving a resolution around 1.5–2 wavelengths from the realistic test data compared to half wavelength from the idealized case. These results were validated with experimental data, and also extended to a realistic corrosion patch confirming the trends demonstrated with simple defects. The resolution loss with realistic data compared with idealized data indicates the acoustic model cannot accurately capture guided wave scattering and an alternative approach is necessary for better resolution reconstructions.
Pneumatic valves based on Magnetic Shape Memory Alloys: Potential applications (2011)

The available deformation range, forces and frequency of the Magnetic Shape Memory Alloys (MSMA) render them suitable for applications in electro-mechanical transducers, used to control pneumatic valves. A fast-operating electro-mechanical transducers can be designed, whose driving elements should not execute any motion, as they do in valves available to date, and which should get deformed instead. Utilising the deformation of an element made from the MSMA, the active element of the valves may be shifted, thus changing the flow orifice. Valves made of MSMA can become a new group of electric valves, featuring improved dynamic behavior and better resistance to external vibrations. The first applications of valves made of MSMA are expected in direct-action proportional throttling valves.