gebhart/patrepeval huggingface dataset:
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes (2003)

Libraries of RNA helicase-coupled randomized ribozymes are a powerful tool for the identification of functional genes. We have demonstrated the usefulness of this functional gene-discovery system by identifying genes involved in tumor invasion, a process that is an essential feature of tumor metastasis: the spread of cancer cells from the original tumor to other sites in the body that imposes serious problems in the prognosis and treatment of cancer. Using a filter-based invasion assay in vitro, we isolated ribozymes that enhanced the invasive properties of NIH 3T3 fibroblasts. Sequence analysis of selected clones and a database search revealed that genes such as the gene for Gem GTPase and uncharacterized genes that resemble genes for myosin phosphatase and protein-tyrosine-phosphatase are involved in cell invasion. Our system for gene identification by using ribozymes and the functional analysis of target genes should help to clarify the complex mechanisms of invasion and metastasis and might provide information that is relevant to cancer therapy.
EFFECTS OF THE EXPLICIT EXPLANATION OF THE GRAMMATICAL RULES IN THE COMMUNICATIVE APPROACH ON LEARNING AND MOTIVATION TO LEARN (1994)

The purposes of this study were 1) t o examine the effects of the Communicative approach with explicit explanation of grammatical rules (the commun icative activity + rules method) on learning, 2) to investigate the effects of the communicat ive activity + rules method on learners' motivation to learn and their recognition of English learning, and 3) to examine the relationship between learners' aptitudes an d teaching methods: i. e. ATI effects. In order to investigate the communicative act ivity + rules method, the Communicative approach without explanation of rules was adopted as a control method. Sixty-eight sixth graders who had experience in lea rning English as beginners for six hours, were assigned to one of the two methods and were taught English for about eight hours. The results indicated that the communic ative activity + rules method produced no difference on academic resu lts, but it decreased the learners' motivation to learn. Also, the results showed that learners i n the communicative activity + rules method tended to recognize that in English learning, the grammatical rules was the most important. Furthermore, six ATI e ffects were observed between learners' aptitudes and the two teaching methods.
A Proposal for Fast Optical Switch using Two-photon Absorption Coupled Ring-resonator to MZI (2006)

Optical switches are very important devices for high-speed optical communications, optical digital integrated circuits, and optical conditioners such as analog to digital converters. High speed optical switching is one of the most important topics in this domain. For this purpose, we investigate the effect of two-photon absorption phenomenon on switching speed in a novel structure. In this paper, Kerr-like nonlinear ring resonator coupled to MZI with considerable two-photon absorption coefficient as a fast optical switch is investigated.
Seed-Mediated Growth of Nearly Monodisperse Palladium Nanocubes with Controllable Sizes (2008)

Nearly monodisperse Pd nanocubes with controllable sizes were synthesized through a seed-mediated growth approach. By using Pd nanocubes of 22 nm in size as seeds, the morphology of the as-grown nanostructures was fixed as single-crystalline, which enabled us to rationally tune the size of Pd nanocubes. The formation mechanism of initial 22 nm nanocubes was also discussed. The size-dependent surface plasmon resonance properties of the as-synthesized Pd nanocubes were investigated. Compared with previous methods, the yield, monodispersity, perfection of the shape formation, and the range of size control of these nanocubes are all improved. These Pd nanocubes may have potential interests in surface-enhanced Raman scattering, sensors, catalysis, study of size-dependent properties, and fabrication of high-order structures.
Stereotomography : A fast approach for velocity macro‐model estimation (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003Stereotomography : A fast approach for velocity macro‐model estimationAuthors: G. LambaréM. AleriniR. BainaP. PodvinG. LambaréÉcole des Mines de Paris, 35 rue Saint Honoré, 77 305 Fontainebleau Cedex, France, M. Alerini, R. BainaOPERA, Ba⁁timent I.F.R., rue Jules Ferry, 64000 Pau, France, and P. PodvinÉcole des Mines de Paris, 35 rue Saint Honoré, 77 305 Fontainebleau Cedex, Francehttps://doi.org/10.1190/1.1817742 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1817742FiguresReferencesRelatedDetailsCited ByVelocity-independent τ-p moveout in a horizontally layered VTI mediumLorenzo Casasanta and Sergey Fomel16 June 2011 | GEOPHYSICS, Vol. 76, No. 4Automatic sub‐salt velocity analysis: an integrated strategy of ray‐based tomography and wave‐equation migration velocity inversionPeng Shen, Elive Menyoli, and Henri Calandra7 December 2005 SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 03 Jan 2005 CITATION INFORMATION G. Lambaré, M. Alerini, R. Baina, and P. Podvin, (2003), "Stereotomography : A fast approach for velocity macro‐model estimation," SEG Technical Program Expanded Abstracts : 2076-2079. https://doi.org/10.1190/1.1817742 Plain-Language Summary PDF DownloadLoading ...
[Workplace health promotion: evaluation of evidence of efficacy and methodological recommendations]. (2009)

Health promotion projects involve the use of public resources so it is necessary that the potential impact and efficacy be evaluated in the planning process. In particular, it is advisable to examine the data in the literature and assign preference to projects that have proved efficacious.
Effects of<i>β</i>‐Carotene repletion on<i>β</i>‐carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men (1990)

The chemopreventive effects of beta-carotene are usually attributed to its antioxidant properties. To determine the effects of beta-carotene supplementation on different parameters of oxidative metabolism, 15 normal young male subjects (18-30 yrs) were placed on a carotenoid-free liquid diet for two weeks prior to entry into the study. Blood was then measured for five carotenoids, retinol, retinyl palmitate, retinol-binding protein, alpha-tocopherol, vitamin C, zinc, lipid peroxides, and neutrophil superoxide production. Absorption tests were performed with 15 mg of beta-carotene to determine absorption curves for each subject. Subjects were then divided into two groups and given either 15 (n = 7) or 120 (n = 8) mg of beta-carotene daily for four weeks along with the same carotenoid-free liquid diet. The absorption test and the blood measurements were repeated. After repletion with beta-carotene, serum lipid peroxide levels decreased in both groups (p less than 0.05), but no other changes were noted in either the neutrophil superoxide production or in the levels of any of the vitamins measured. In contrast to vitamin E, the superoxide scavenging ability of beta-carotene apparently does not contribute to its effects in lowering serum lipid peroxide levels.
Electrochemistry of 9,9′-spirobifluorene derivatives: 2-acetyl- and 2,2′-diacetyl-9,9′-spirobifluorene. Preparation of stereoisomeric 2,3-bis(9,9′-spirobifluoren-2-yl)butane-2,3-diols (1993)

2-Acetyl- and 2,2′-diacetyl-9,9′spirobifluorene 1 and 2 were studied by cyclic voltammetry in dimethylformamide. The corresponding anion radicals show remarkable persistency in aprotic DMF. The (apparent) standard potentials are E°=–1.77 V (SCE) and E°=–1.75 V for the (quasi-reversible) reduction of 1 and 2 to the anion radicals, respectively. Preparative electrolysis of 1 in DMF–Et4NClO4(0.1 mol dm–3), with excess acetic acid as proton donor, furnished alcohol 3 and the diastereoisomeric pinacols 5 and 6, which were isolated and characterized. The diastereoisomeric excess, de, as evaluated (NMR) on the electrolyzed solution was only slightly in favour of the (±) compound. Spectroscopic properties of compounds 1–6 are, inter alia, the 13C NMR chemical shift for the spiro-carbon at δ= 65.9 (TMS), and the fragmentation patterns in the mass spectra, with the 100% relative abundance of the molecular-ion M˙+ in the case of the aromatic ketones 1 and 2. Some comments on the influence of conformations of 5 and 6 and of the presence of an intramolecular hydrogen-bond in some intermediates and products are also presented.
A NLLS Based Sub-Nyquist Rate Spectrum Sensing for Wideband Cognitive Radio (2014)

For systems and devices, such as cognitive radio and networks, that need to be aware of available frequency bands, spectrum sensing has an important role. A major challenge in this area is the requirement of a high sampling rate in the sensing of a wideband signal. In this paper a wideband spectrum sensing method is presented that utilizes a sub-Nyquist sampling scheme to bring substantial savings in terms of the sampling rate. The correlation matrix of a finite number of noisy samples is computed and used by a non-linear least square (NLLS) estimator to detect the occupied and vacant channels of the spectrum. We provide an expression for the detection threshold as a function of sampling parameters and noise power. Also, a sequential forward selection algorithm is presented to find the occupied channels with low complexity. The method can be applied to both correlated and uncorrelated wideband multichannel signals. A comparison with conventional energy detection using Nyquist-rate sampling shows that the proposed scheme can yield similar performance for SNR above 4 dB with a factor of 3 smaller sampling rate.
A 1.2V 38nm 2.4Gb/s/pin 2Gb DDR4 SDRAM with bank group and &#x00D7;4 half-page architecture (2012)

DDR4 SDRAM is expected to realize low power consumption and high bandwidth using a 1.2V nominal supply voltage and to be a cost-effective solution for various applications. In this paper, bank group architecture, internal reference voltage level (IVREF) and pre-emphasis to overcome conventional operating frequency range are presented. CS_n to command/address latency (CAL), data bus inversion (DBI) and ×4 half-page architecture are introduced to reduce current consumption. Cyclic redundancy check (CRC) and command and address (CA) parity are adopted to check transmission errors in high bandwidth. Also, read CRC with DBI is calculated in parallel to mitigate calculation time and area penalty. Consequently, our 2Gb DDR4 SDRAM achieves 2.4Gb/s data rate at 1.0V supply voltage.
Carbon Interdigitated Array Nanoelectrodes for Electrochemical Applications (2011)

Redox current amplification has been demonstrated using carbon interdigitated array (IDA) nanoelectrodes derived from precursor polymer microstructures through conventional photolithography and pyrolysis. This simple conversion process, also known as carbon-microelectromechanical systems, enables nanometer-level fabrication of carbon materials in a reproducible and an economic manner. We demonstrated that with carbon IDA nanoelectrodes fabricated in two mask processes a current amplification factor of 25 can be obtained. This high amplification factor is a result of the efficient recycling of redox species between the 1:1 aspect ratio carbon nanoelectrodes. This type of a current amplification value is hard to obtain when using more traditional flat nanometer level spaced noble metal IDA electrodes fabricated with more expensive nanopatterning processes such as E-beam lithography.
The Longitudinal Orthokeratology Research in Children (LORIC) in Hong Kong: A Pilot Study on Refractive Changes and Myopic Control (2005)

Ortho-k can have both a corrective and preventive/control effect in childhood myopia. However, there are substantial variations in changes in eye length among children and there is no way to predict the effect for individual subjects.
Thiation with Phosphorus Pentasulfide in Pyridine Solution (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiation with Phosphorus Pentasulfide in Pyridine SolutionErwin Klingsberg and Domenick PapaCite this: J. Am. Chem. Soc. 1951, 73, 10, 4988–4989Publication Date (Print):October 1, 1951Publication History Published online1 May 2002Published inissue 1 October 1951https://doi.org/10.1021/ja01154a527RIGHTS & PERMISSIONSArticle Views411Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (281 KB) Get e-Alertsclose Get e-Alerts
High-performance and Low-power Clock Network Synthesis in the Presence of Variation (2011)

Semiconductor technology scaling requires continuous evolution of all aspects of physical design of integrated circuits. Among the major design steps, clock-network synthesis has been greatly affected by technology scaling, rendering existing methodologies inadequate. Clock routing was previously sufficient for smaller ICs, but design difficulty and structural complexity have greatly increased as interconnect delay and clock frequency increased in the 1990s. Since a clock network directly influences IC performance and often consumes a substantial portion of total power, both academia and industry developed synthesis methodologies to achieve low skew, low power and robustness from PVT variations. Nevertheless, clock network synthesis under tight constraints is currently the least automated step in physical design and requires significant manual intervention, undermining turn-around-time. The need for multi-objective optimization over a large parameter space and the increasing impact of process variation make clock network synthesis particularly challenging. Our work identifies new objectives, constraints and concerns in the clock-network synthesis for systems-on-chips and microprocessors. To address them, we generate novel clock-network structures and propose changes in traditional physical-design flows. We develop new modeling techniques and algorithms for clock power optimization subject to tight skew constraints in the presence of process variations. In particular, we offer SPICE-accurate optimizations of clock networks, coordinated to reduce nominal skew below 5 ps, satisfy slew constraints and trade-off skew, insertion delay and power, while tolerating variations. To broaden the scope of clock-network-synthesis optimizations, we propose new techniques and a methodology to reduce dynamic power consumption by 6.8%-11.6% for large IC designs with macro blocks by integrating clock network synthesis within global placement. We also present a novel non-tree topology that is 2.3x more power-efficient than mesh structures. We fuse several clock trees to create large-scale redundancy in a clock network to bridge the gap between tree-like and mesh-like topologies. Integrated optimization techniques for high-quality clock networks described in this dissertation strong empirical results in experiments with recent industry-released benchmarks in the presence of process variation. Our software implementations were recognized with the first-place awards at the ISPD 2009 and ISPD 2010 Clock-Network Synthesis Contests organized by IBM Research and Intel Research.
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed‐batch CHO cell culture (2013)

Cell metabolism can vary considerably over the course of a typical fed-batch antibody production process. However, the intracellular pathway alterations associated with various phases of growth and antibody production have yet to be fully elucidated using industrially relevant production hosts. Therefore, we performed (13)C labeling experiments and metabolic flux analysis (MFA) to characterize CHO cell metabolism during four separate phases of a fed-batch culture designed to closely represent industrial process conditions. First, we found that peak specific growth rate was associated with high lactate production and minimal TCA cycling. Conversely, we found that lactate metabolism switched from net production to net consumption as the culture transitioned from peak growth to peak antibody production. During the peak antibody production phase, energy was primarily generated through oxidative phosphorylation, which was also associated with elevated oxidative pentose phosphate pathway (oxPPP) activity. Interestingly, as TCA cycling and antibody production reached their peaks, specific growth rate continued to diminish as the culture entered stationary phase. However, TCA cycling and oxPPP activity remained high even as viable cell density began to decline. Overall, we found that a highly oxidative state of metabolism corresponded with peak antibody production, whereas peak cell growth was characterized by a highly glycolytic metabolic state.
Hydride Transfer. Reactions of Triphenylcarbonium Fluoroborate and Triphenylmethyl Bromide with Tertiary Amines (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydride Transfer. Reactions of Triphenylcarbonium Fluoroborate and Triphenylmethyl Bromide with Tertiary AminesRalph Damico and C. D. BroaddusCite this: J. Org. Chem. 1966, 31, 5, 1607–1612Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/jo01343a068https://doi.org/10.1021/jo01343a068research-articleACS PublicationsRequest reuse permissionsArticle Views676Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Collaborate or Compete: How Do Landlords Respond to the Rise in Coworking? (2014)

Changes in technology, attitudes toward work, and the new ‘shared economy’ have created an environment in which people have more options for how, when and where to work. Working from home, telecommuting, hoteling, and collaborative workspaces are on the rise nationally. According to 2010 Census data, 4.3% of the 137 million workers in the United States telecommuted compared to 3.7% in 2005.1 Technology has been a major catalyst, helping to disseminate knowledge, increase communication, and allow people more independence and control over their work and life. The ubiquitous ‘coffee shop entrepreneur’ that migrates from their home-based office to the nearest cafe has largely given way to a new group of start-up oriented individuals and businesses that recognize the need for innovative and functional space.
TH-3 Microwave Radio System: Microwave Integrated Circuits (1971)

Microwave integrated circuits have been employed in the Bell System for the first time in the TH-3 radio system. These circuits, using strip transmission lines, provide numerous functions previously achieved with assemblies of individual waveguide components. By utilizing the modern technologies of photolithography, precision die casting, ceramic processing, and tantalum-gold thin films, these circuits provide advantages in size, fabrication, bay “layout,” performance, and cost.
Power Requirements of Melt Extruders (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPower Requirements of Melt ExtrudersR. S. Mallouk and J. M. McKelveyCite this: Ind. Eng. Chem. 1953, 45, 5, 987–989Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ie50521a035https://doi.org/10.1021/ie50521a035research-articleACS PublicationsRequest reuse permissionsArticle Views337Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The experimental test and FEA of a PKM (Exechon) in a flexible fixture application for aircraft wing assembly (2011)

The parallel kinematics machine (PKM) Exechon is proposed to be used in a flexible fixture for aircraft wing assembly. The analysis and tests are required to determine the capability of the proposed fixturing solution. The research concern in this paper will be the static stiffness analysis of the Exechon device, which will be a very important element of flexible fixturing solution for aircraft wing assembly using parallel kinematics machines. This section will detail the experimental test of the Exechon machine's stiffness to understand its stiffness character and to provide guidelines and validation data for Finite Element Analysis (FEA) work in developing analysis models of the Exe-chon device with more representative stiffness characters. The preliminary FEA work in solid models and beam models will also be included.
Fluorescence from photoexcitation of CF3X (X=H, Cl, and Br) at 50–106 nm (1990)

The photoabsorption and fluorescence cross sections of CF3H, CF3Cl, and CF3Br are measured in the 50–106 nm region using synchrotron radiation. Fluorescence spectra from photoexcitation of these molecules are dispersed to identify the emitting species to be mainly the excited CF*2, CF*3, and CF3X+*, but not CF+*3. The fluorescence excitation function of CF3X (X=F, H, Cl, or Br) is generally divided into three excitation bands; each band produces a specific excited species. The fluorescence yields of the studied molecules are determined and correlated with dissociation thresholds and ionization potentials. The excited ion states that may emit are discussed.