gebhart/patrepeval huggingface dataset:
Long-Term Inhaled Corticosteroids in Preschool Children at High Risk for Asthma (2006)

In preschool children at high risk for asthma, two years of inhaled-corticosteroid therapy did not change the development of asthma symptoms or lung function during a third, treatment-free year. These findings do not provide support for a subsequent disease-modifying effect of inhaled corticosteroids after the treatment is discontinued. (ClinicalTrials.gov number, NCT00272441.).
Systematic testing for control applications (2010)

Software controllers for physical processes are at the core of many safety-critical systems such as avionics, automotive engine control, and process control. Despite their importance, the design and implementation of software controllers remains an art form; dependability is generally poor, and the cost of verifying systems is prohibitive. We illustrate the potential of applying program analysis tools on problems in controller design and implementation by focusing on concolic execution, a technique for systematic testing for software. In particular, we demonstrate how a concolic execution tool can be modified to automatically analyze controller implementations and (a) produce test cases achieving a coverage goal, (b) synthesize ranges for controller variables that can be used to allocate bits in a fixed-point implementation, and (c) verify robustness of an implementation under input uncertainties. We have implemented these algorithms on top of the Splat test generation tool and have carried out preliminary experiments on control software that demonstrates feasibility of the techniques.
Production, characterization, and application of monoclonal antibodies which distinguish three glucosyltransferases from Streptococcus mutans (1993)

Thirty-three murine monoclonal antibodies (MAbs) against the three glucosyltransferases (GTFs) (GTF-I, -SI, and -S) from Streptococcus mutans were obtained by the fusion of murine myeloma cells (P3X63-Ag8-U1) with spleen cells of BALB/c mice immunized with pure GTF-S or partially purified GTF-I from serotype c S. mutans PS14. The immunoreactivities of these MAbs were tested by enzyme-linked immunosorbent assay and Western blotting (immunoblotting) with various GTF preparations. GTF-I and GTF-SI were expressed from two Streptococcus milleri or Escherichia coli transformants harboring gtfB or gtfC, respectively. All of the five MAbs raised against the GTF-S from PS14 reacted only with the homologous enzymes. Of these, 8 MAbs reacted only with the gtfB gene product (GTF-I), 4 MAbs reacted only with the gtfC gene product (GTF-SI), and the remaining 16 MAbs reacted with both gene products. The existence of GTF-SI in the purified GTF-I from PS14 was demonstrated by Western blot analysis using the representative monospecific MAbs. Further, the relative levels of the three GTFs in the extracellular and cellular fractions of S. mutans clinical isolates were examined by immunoblot analysis. The findings indicated that the relative level of GTF-SI, unlike that of GTF-I or GTF-S, differed markedly among isolates although the three GTFs were synthesized extracellularly by all the strains.
A genetic system for Archaea of the genus <i>Methanosarcina</i> : Liposome-mediated transformation and construction of shuttle vectors (1997)

New methods that allow, for the first time, genetic analysis in Archaea of the genus Methanosarcina are presented. First, several autonomously replicating plasmid shuttle vectors have been constructed based on the naturally occurring plasmid pC2A from Methanosarcina acetivorans. These vectors replicate in 9 of 11 Methanosarcina strains tested and in Escherichia coli. Second, a highly efficient transformation system based upon introduction of DNA by liposomes has been developed. This method allows transformation frequencies of as high as 2 x 10(8) transformants per microgram of DNA per 10(9) cells or approximately 20% of the recipient population. During the course of this work, the complete 5467-bp DNA sequence of pC2A was determined. The implications of these findings for the future of methanoarchaeal research are also discussed.
Calcium Metabolism in Health and Disease (2010)

This brief review focuses on calcium balance and homeostasis and their relationship to dietary calcium intake and calcium supplementation in healthy subjects and patients with chronic kidney disease and mineral bone disorders (CKD-MBD). Calcium balance refers to the state of the calcium body stores, primarily in bone, which are largely a function of dietary intake, intestinal absorption, renal excretion, and bone remodeling. Bone calcium balance can be positive, neutral, or negative, depending on a number of factors, including growth, aging, and acquired or inherited disorders. Calcium homeostasis refers to the hormonal regulation of serum ionized calcium by parathyroid hormone, 1,25-dihydroxyvitamin D, and serum ionized calcium itself, which together regulate calcium transport at the gut, kidney, and bone. Hypercalcemia and hypocalcemia indicate serious disruption of calcium homeostasis but do not reflect calcium balance on their own. Calcium balance studies have determined the dietary and supplemental calcium requirements needed to optimize bone mass in healthy subjects. However, similar studies are needed in CKD-MBD, which disrupts both calcium balance and homeostasis, because these data in healthy subjects may not be generalizable to this patient group. Importantly, increasing evidence suggests that calcium supplementation may enhance soft tissue calcification and cardiovascular disease in CKD-MBD. Further research is needed to elucidate the risks and mechanisms of soft tissue calcification with calcium supplementation in both healthy subjects and CKD-MBD patients.
Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707M (1990)

A primitive neuroectodermal tumor (PNET) presented as a cerebral hemispheric mass in a 33-year-old man. Bone marrow metastases were discovered 11 months later. A cell line (CHP707m) was derived from these metastases. In culture, the cells showed features of neuronal differentiation, forming short neurites and synthesizing low-molecular-weight neurofilament protein. Northern blotting showed the tumor cells express nerve growth factor (NGF) receptor messenger RNA, and fluorescence-activated cell-sorting demonstrated NGF receptors on the cell surface. Western blotting showed CHP707m NGF receptors are truncated. The receptors are functional; they bind iodine 125-labeled mouse NGF with an affinity of 1.6 x 10(-9) M, and short-term treatment with NGF induces expression by the tumor cells of the proto-oncogene, c-fos. Although CHP707m is the first central nervous system PNET cell line proven to express NGF receptors, immunohistological survey of tissue sections prepared from human central nervous system PNETs showed that 13 of 35 contained NGF receptor-positive tumor cells. Thus, more than one-third of such tumors might be responsive to the effects of NGF.
One-bit sparse array DOA estimation (2017)

One-bit quantization has become an important topic in massive MIMO systems, as it offers low cost and low complexity in the implementation. Techniques to achieve high performance in spite of the coarse quantizers have recently been advanced. In the context of array processing and direction-of-arrival (DOA) estimation also, one bit quantizers have been studied in the past, although not as extensively. This paper shows that sparse arrays such as nested and coprime arrays are more robust to the deleterious effects of one-bit quantization, compared to uniform linear arrays (ULAs); in fact, sparse arrays with one-bit quantizers are often found to be as good as ULAs with unquantized data. Nested and coprime arrays without quanitzers are known to be able to resolve more DOAs than the number of sensors, when sources are uncorrelated. It will be demonstrated that this continues to be true even with one-bit quantization.
<i>β</i> -Amyloid Peptide Vaccination Results in Marked Changes in Serum and Brain A <i>β</i> Levels in APPswe/PS1ΔE9 Mice, as Detected by SELDI-TOF-Based ProteinChip <sup>®</sup> Technology (2001)

Although the pathogenesis of Alzheimer's disease (AD) is not fully understood, growing evidence indicates that the deposition of beta-amyloid (Abeta) and the local reactions of various cell types to this protein play major roles in the development of the disease. Immunization with the Abeta 1-42 peptide has been reported to decrease Abeta deposits in the brains of mutant amyloid precursor protein (APP/V717F) transgenic (tg) mice (Schenk et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177). We have replicated this finding in APPswe/PS1DeltaE9 tg mice, which also develop Abeta deposits in the brain. The immunized animals developed high titers of antibodies against Abeta 1-42 in serum, and Abeta deposits in the brains were significantly reduced. Using surface-enhanced laser desorption/ionization (SELDI) mass spectrometry and ProteinChip((R)) technology, we detected trends toward increased soluble Abeta peptide in the brain and a decrease in assayable Abeta peptide in the serum of immunized compared with control animals. This last finding raises the possibility that anti-Abeta antibodies in the periphery sequester Abeta peptides or target them for degradation and in this way contribute to the enhanced Abeta clearance from the brain in immunized animals.
A rotating laser doppler velocimeter and some new results on the spin-up experiment (1975)

Abstract A laser Doppler velocimeter (LDV) has been successfully mounted on a high quality rotating turntable. The capability of this LDV is demonstrated by some detailed measurements of the relative flow during the spin-up of a homogeneous fluid in a cylinder. Local measurements in water of the zonal flow component of magnitude 0.1 cm/sec have been made with an error of about 0.003 cm/sec. The spatial resolution was about 0.1 cm and the temporal resolution about 0.5 Hz. Effects on the flow due to absorption of the low power laser beam (5 milliwatts) and to the low concentration (3 parts/million) of 0.5 micron diameter scattering particles were negligible. The results are compared with analytical theory and the agreement is good. For a Rossby number of 0.1, the weak inertial modes excited by the Ekman layer formation can be clearly seen and identified. The LDV offers great promise for checking numerical and analytical solutions against experiments. This is particularly true for contained flows where conventional probes often significantly disturb the flow.
Naturally occurring anti-native DNA antibodies in SLE binding Z-DNA. (1990)

A high degree of specificity of circulating anti-DNA antibody for double stranded DNA in the sera of SLE patients was found, as compared to single stranded polymer. The antibody recognized brominated DNA, a polymer that appears to attain Z-conformation as indicated on the basis of UV absorption characteristics. The existence in native DNA of regions undergoing B----Z transition has been detected.
The effect of self-identity on body shape management (2017)

The purpose of this study was to investigate the effects of self-identity on body shape management for college students. This study used descriptive research to analyze the effects of self-identity, which has contained factors of Subjectivity, Self-acceptance, Future Confidence, Goal Orientation, Scrupulous. The subjects were 404 college students located in C province who were voluntarily agreed. Multiple regression analysis was conducted to verify the effects on self - identity and body shape management. As a result, self - acceptance of self - identity' subcomponents had no effect on body shape management, but future confirmation, goal orientation, Scrupulous, intimacy affects body shape management(P < 0.001). Based on these results, in order to manage the body shape of college students, it is considered effective to present the visible goals and apply the programs that students can do themselves. In addition, it can be seen that it is effective to start body shape management during college group life to enhance intimacy.
United States Military Casualty Statistics: Operation Iraqi Freedom and Operation Enduring Freedom (2009)

This report presents difficult-to-find statistics regarding U.S. military casualties in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF, Afghanistan), including those concerning medical evacuations, amputations, and the demographics of casualties. Some of these statistics are publicly available at the Department of Defense's (DoD's) website, while others have been obtained through contact with experts at DoD. Daily updates of total U.S. military casualties in OIF and OEF can be found at the DoD's website, at [http://www.dior.whs.mil/mmid/casualty/castop.htm]. In addition, the CRS Report RS21578, "Iraq: Summary of U.S. Casualties" is updated on a weekly basis. This report will be updated as needed.
Lateral grating array high power CW visible semiconductor laser (1982)

A periodic, grating-like array of substrate grooves oriented parallel to the longitudinal axis of the laser provides a small periodic lateral thickness modulation of the active region of an MO-CVD-grown Ga1−xAlxAs laser producing phase-locked operation at 7680 Å. CW output powers as high as 138 mW/facet have been obtained.
Evidence for task-dependent memory dysfunction in the aged monkey (1989)

Experimentally naive adult (9-11 years old) and aged (approximately 22-26 years old) female rhesus monkeys were evaluated on 3 neuropsychological tests of memory function. Aged monkeys were impaired in a delayed response test of visuospatial memory when the retention interval of the task was increased from 0 to 10 sec. These animals performed as well as younger subjects, however, at very short delays (0 and 1 sec), when the memory demands of the task were minimal. The same subjects were then trained in a delayed nonmatching to sample (DNMS) test of visual object recognition memory. Although they required significantly more training than the younger subjects to learn the nonmatching principle of the task, aged animals were only minimally impaired when recognition memory was tested at retention intervals ranging from 10 sec to 22 hr. In contrast to their relatively intact performance on the object recognition task, aged monkeys were dramatically impaired in a second version of DNMS that required subjects to remember the temporal order in which objects were presented. These findings support the view that certain memory functions are differentially susceptible to age-dependent deterioration. Since neuropsychological studies in young subjects demonstrate that different brain regions make relatively specific contributions to learning and memory, the task-dependent deficits observed in the aged monkey are important for determining which neural structures mediate age-dependent cognitive dysfunction. According to this perspective, aged monkeys were impaired on tasks known to be sensitive to prefrontal cortical damage, but the same animals performed well on a DNMS procedure that subjects with medial temporal lobe damage fail. These results suggest that prefrontal cortical dysfunction may mediate prominent aspects of age-dependent cognitive impairment in the monkey.
Review of ladar: a historic, yet emerging, sensor technology with rich phenomenology (2012)

Ladar is becoming more prominent due to the maturation of its component technologies, especially lasers. There are many forms of ladar. There is simple two-dimensional (2-D) ladar, similar to a passive electro-optic sensor, but with controlled illumination and the ability to see at night even at short wavelengths. There is three-dimensional (3-D) ladar, with angle/angle/range information. 3-D images are very powerful because shape is an invariant. 3-D images can be easily rotated to various perspectives. You can add gray scale or color, just like passive, or 2-D ladar, imaging. You can add precise velocity measurement, including vibrations. Ladar generates orders of magnitude higher frequency change then microwave radar for velocity measurement, because frequency change is proportional to one over the wavelength. Orders of magnitude higher frequency change means you can measure a given velocity orders of magnitude quicker, in many cases making an accurate measurement possible. Polarization can be used. With an active sensor you control both the illumination and the reception, so you can pattern the illumination. Also, because ladar can use narrow band illumination it is easier to easier to coherently combine sub-aperture images to obtain the higher resolution of an array.
Mechanical properties and the hierarchical structure of bone (1998)

Detailed descriptions of the structural features of bone abound in the literature; however, the mechanical properties of bone, in particular those at the micro- and nano-structural level, remain poorly understood. This paper surveys the mechanical data that are available, with an emphasis on the relationship between the complex hierarchical structure of bone and its mechanical properties. Attempts to predict the mechanical properties of bone by applying composite rule of mixtures formulae have been only moderately successful, making it clear that an accurate model should include the molecular interactions or physical mechanisms involved in transfer of load across the bone material subunits. Models of this sort cannot be constructed before more information is available about the interactions between the various organic and inorganic components. Therefore, further investigations of mechanical properties at the 'materials level', in addition to the studies at the 'structural level' are needed to fill the gap in our present knowledge and to achieve a complete understanding of the mechanical properties of bone.
Chemistry of Sulforhodamine−Amine Conjugates (2001)

Commercially-available sulforhodamine sulfonyl chlorides contain two isomeric monosulfonyl chlorides. Conjugates of these isomers with amines have different properties because the sulfonamide formed from one isomer can undergo ring-closure to a colorless sultam. This chemistry has been examined for a model conjugate with methylamine and for a bioconjugate with 2'(3')-O-[N-(2-aminoethyl)carbamoyl]ATP. The interaction of each isomer of the latter conjugates with myosin subfragment 1 has been characterized. Significant differences between the two isomers are observed in these interactions.
Why Do Banks Merge? (2002)

The banking industry is consolidating at an accelerating pace, yet no conclusive results have emerged on the benefits of mergers and acquisitions. In order to investigate the motives and results of each type of deal we consider separately acquisitions (that is, the purchase of the majority of voting shares) and mergers, using Italian data. Mergers seek to improve income from services, but the increase is offset by higher staff costs; return on equity improves because of a decrease in capital. Acquisitions aim to restructure the loan portfolio of the acquired bank; improved lending policies result in higher profits.
Rolling resistance moment of microspheres on surfaces: contact measurements (2007)

Using contact measurements, experimental evidence was obtained for the existence of the rolling resistance moment. The critical rolling distance prior to detachment is reported. Previously it has been argued that the critical rolling distance should be related to the lattice size and/or the molecular length of the particle and surface materials. However, there has been no theoretical prediction for the critical value and, currently, the reasons for its existence are not fully understood. For polystyrene latex (PSL) particles, measurements presented in the current study on silicon suggest much higher values for the critical rolling distance than previous anticipated levels. The current approach can also be employed to measure the work of adhesion between a spherical particle and a flat surface without the prior knowledge of the particle diameter since the rolling moment stiffness is directly proportional to the work of adhesion with no dependence on the diameter of the particle. Experimental results are compared with the available data and good agreement between the theoretical predictions and the experimental values is found.
Coincidence resolution time of two small scintillators coupled to high quantum-efficiency photomultipliers in a PET-like system (2014)

The lower limit of the time resolution for a positron emission tomography (PET) system has been measured for two scintillator types, LYSO:Ce and LuAG:Pr. Small dimension crystals and ultra bi-alkali phototubes have been used in order to increase the detected scintillation photons. Good timing resolutions of 118 ps and 223 ps FWHM have been obtained for two LYSO and two LuAG, respectively, exposed to a 22Na source.
ChemInform Abstract: A GENERAL SYNTHESIS OF BENZO‐1,4‐DITHIAFULVALENES BY CARBONYL OLEFINATION (1978)

Abstract 2‐(0,0‐Dimethylphosphonyl)‐I ,3‐benzodithiol (I) ergibt mit Ketonen (II) in guten Ausbeuten Benzo‐1,4‐dithiafulvalene bzw. ‐fulvene (III).
DNA sequence of regulatory region for integration gene of bacteriophage λ (1980)

The cII and cIII proteins specified by bacteriophage lambda direct the lysogenic response to infection through the coordinate establishment of repression and integration of the viral DNA. The regulatory activity of cII/cIII involves positive regulation of two promoter sites: the p(E) promoter, turning on expression of the cI protein that maintains lysogeny, and the p(I) promoter, activating synthesis of the Int protein for integrative recombination. Regulation of the p(I) promoter provides for differential expression of the Int protein with respect to the excision-specific Xis protein from the closely linked int and xis genes. We have determined the DNA sequence of the p(I) promoter region for wild-type lambda DNA and for two classes of mutations: intc mutations, which result in a high rate of Int synthesis in the absence of cII, and deletion mutations, some of which eliminate cII-activated expression of the int gene. We find a sequence with considerable homology (11 of 15 bases) to a "typical" (computer-generated) promoter sequence, adjacent to a region with striking homology (11 of 14 bases) to part of the p(E) promoter region. This presumed p(I) sequence overlaps the start of the xis gene and includes the site of two intc point mutations. A cII-insensitive xis(+) deletion partially removes the proposed p(I) sequence; a deletion that leaves the p(I) sequence intact but terminates 21 bases upstream does not interfere with cII activation of the int gene. From our results and the analysis of the p(E) region, we suggest that cII acts in the promoter -35 recognition region to facilitate binding by RNA polymerase at the -10 interaction region. Differential expression of the int and xis genes results because the p(I) transcript lacks the initiation codon for Xis protein synthesis.
Random Resonators and Prelocalized Modes in Disordered Dielectric Films (2002)

We calculate the areal density of disorder-induced resonators with a high quality factor, Q>>1, in a film with fluctuating refraction index. We demonstrate that, for a given kl>1, where k is the light wave vector and l is the transport mean-free path, when on average the light propagation is diffusive, the likelihood for finding a random resonator increases dramatically with increasing the correlation radius of the disorder. Parameters of most probable resonators as functions of Q and kl are found.