gebhart/patrepeval huggingface dataset:
A critical investigation of polyethylene gas permeability (1962)

Abstract The effect of polymer density on the gas permeability of polyethylene film has been studied. The experimental data for permeability P are described by the equation P = K (1 — d ) n , where K is a constant characteristic of each gas and d is the sample density. This equation is similar to previous analytical descriptions of the permeability—density relation. Values of K and n ( n ≈ 2) and confidence limits for P are given for N 2 , O 2 , and CO 2 . Permeability—density values are reported for approximately 100 film samples for each of the three gases over a density range from 0.899 to 0.975 g./cc. The density was measured for each sample inserted in the permeability apparatus. The above mathematical model chosen to describe the experimental data is interpreted to mean that the effect of the crystalline phase is to decrease both the gas solubility and diffusion. Gas solubility and diffusion are linear functions of the volume fraction of amorphous material. Permeability, the product of diffusion and solubility, is consequently proportional to the square of the volume fraction of amorphous material. Permeability is related to density rather than volume fraction of amorphous material to avoid choosing a single value for the density of the amorphous fraction. The experimental results suggest additional lowering of the permeability due to restraints on the segmental motion of the amorphous chains.
On the Mechanism of Quinol Oxidation at the QP Site in the Cytochrome bc1 Complex (2008)

To elucidate the mechanism of bifurcated oxidation of quinol in the cytochrome bc1 complex, Rhodobacter sphaeroides mutants, H198N and H111N, lacking heme bL and heme bH, respectively, were constructed and characterized. Purified mutant complexes have the same subunit composition as that of the wild-type complex, but have only 9-11% of the electron transfer activity, which is sensitive to stigmatellin or myxothiazol. The Em values for hemes bL and bH in the H111N and H198N complexes are -95 and -35 mV, respectively. The pseudo first-order reduction rate constants for hemes bL and bH in H111N and H198N, by ubiquiniol, are 16.3 and 12.4 s(-1), respectively. These indicate that the Qp site in the H111N mutant complex is similar to that in the wild-type complex. Pre-steady state reduction rates of heme c1 by these two mutant complexes decrease to a similar extent of their activity, suggesting that the decrease in electron transfer activity is due to impairment of movement of the head domain of reduced iron-sulfur protein, caused by disruption of electron transfer from heme bL to heme bH. Both mutant complexes produce as much superoxide as does antimycin A-treated wild-type complex. Ascorbate eliminates all superoxide generating activity in the intact or antimycin inhibited wild-type or mutant complexes.
Workflow exception patterns (2006)

This paper presents a classification framework for workflow exception handling in the form of patterns. This framework is independent of specific modelling approaches or technologies and as such provides an objective means of delineating the exception-handling capabilities of specific workflow systems. It is subsequently used to assess the level of exceptions support provided by eight commercial workflow systems and business process modelling and execution languages. On the basis of these investigations, we propose a graphical, tool-independent language for defining exception handling strategies in workflows.
On-Road Measurement of Automotive Particle Emissions by Ultraviolet Lidar and Transmissometer:  Instrument (2003)

A novel vehicle emissions remote sensing system (VERSS) for the on-road measurement of fuel-based particulate matter (PM) emission factors is described. This system utilizes two complementary PM channels using an ultraviolet Lidar and transmissometer for the measurement of PM mass column content behind a passing vehicle. Ratioing the PM mass column content with the carbon mass column content, simultaneously measured with infrared absorption, yields the fuel-based PM mass emission factor. The transmissometer directly yields PM extinction coefficients without calibration, while the Lidar measurement of PM backscatter coefficients is calibrated through laboratory measurements of gases with well-known backscatter coefficients. The PM mass column content is calculated from these extinction and backscatter coefficients with the help of mass backscatter and extinction efficiencies obtained from theoretical calculations. This novel VERSS has been used extensively in a major air quality study, and example data are presented.
The Acid-soluble Components of Adenovirus and of Adenovirus-infected Cells (1971)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Salivary secretions by aphids interacting with proteins of phloem wound responses (2006)

Successful phloem feeding requires overcoming a number of phloem-related plant properties and reactions. The most important hurdle is formed by the phloem wound responses, such as coagulating proteins in the phloem sieve elements of the plant and in the capillary food canal in the insect's mouth parts, i.e. the stylets. It seems that in order to prevent protein clogging inside a sieve element, ejection of watery saliva plays an important role. This ejection is detected in the electrical penetration graph (EPG) as E1 salivation and always precedes phloem sap ingestion. During this feeding from sieve elements, another regular and concurrent salivation also occurs, the watery E2 salivation. This E2 saliva is added to the ingested sap and, it probably prevents phloem proteins from clogging inside the capillary food canal. Whatever the biochemical mode of action of the inhibition of protein coagulation might be, in some plants aphids do not seem to be able to prevent clogging, which may explain the resistance to aphids in these plants. The relevance of this hypothesis is demonstrated by new experimental results and is related to new EPG results from plants with phloem-located resistance.
Secretin. The Synthesis of a “Wrong” Hexapeptide Amide, Sequence 22-27<sup>*</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecretin. The Synthesis of a "Wrong" Hexapeptide Amide, Sequence 22-27*Seymour D. Levine and Miklos BodanszkyCite this: Biochemistry 1966, 5, 11, 3441–3443Publication Date (Print):November 1, 1966Publication History Published online1 May 2002Published inissue 1 November 1966https://pubs.acs.org/doi/10.1021/bi00875a008https://doi.org/10.1021/bi00875a008research-articleACS PublicationsRequest reuse permissionsArticle Views20Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Model-based/waveform hybrid coding for videotelephone images (1991)

An image coding method that combines model-based coding with conventional waveform coding is presented. Despite its potential to realize image communication at very low rates, model-based coding still has many glitches that need to be solved before any practical use. The major problems are the difficulty in modeling unknown objects and the presence of analysis errors. To cope with these difficulties, waveform coding is incorporated into model-based coding. The incorporated waveform coder can code unmodeled objects and cancel errors of the analysis system. A general model of model-based/waveform hybrid coding is discussed. Preliminary simulation results of a model-based/MC-DCT hybrid coding system show that this hybrid coding method is effective at very low transmission rates, such as 16 kb/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T Cells specifically inhibit Ewing sarcoma growth<i>in vitro</i>and<i>in vivo</i> (2016)

The endochondral bone protein Chondromodulin-I (CHM1) provides oncogene addiction in Ewing sarcoma (ES). We pre-clinically tested the targetability of CHM1 by TCR transgenic, allo-restricted, peptide specific T cells to treat ES. We previously generated allo-restricted wildtype CD8+ T cells directed against the ES specific antigen CHM1319 causing specific responses against ES. However, utilization of these cells in current therapy protocols is hampered due to high complexity in production, relatively low cell numbers, and rapid T cell exhaustion.In order to provide off-the-shelf products in the future, we successfully generated HLA-A*02:01-restricted T cell receptor (TCR) transgenic T cells directed against CHM1319 by retroviral transduction.After short-term expansion a 100% purified CHM1319-TCR-transgenic T cell population expressed a CD62L+/CD45RO and CD62L+/CD45RA+ phenotype. These cells displayed specific in vitro IFNg and granzyme B release in co-culture with HLA-A*02:01+ ES cell lines expressing CHM1. When co-injected with ES cells in Rag2-/-É£c-/- mice, CHM1-specific TCR-transgenic T cells significantly inhibited the formation of lung and liver metastases in contrast to control mice. Lungs and livers of representative mice displayed CD8+ T cell infiltration in the presence (control group treated with unspecific T cells) and in the absence (study group) of metastatic disease, respectively. Furthermore, mice receiving unspecific T cells showed signs of graft-versus-host-disease in contrast to all mice, receiving CHM1319-TCR-transgenic T cells.CHM1319 specific TCR-transgenic T cells were successfully generated causing anti-ES responses in vitro and in vivo. In the future, CHM1319-TCR-transgenic T cells may control minimal residual disease rendering donor lymphocyte infusions more efficacious and less toxic.
Development of Cu-64 labeled DOTA-cyanocobalamin for PET imaging (2007)

1387 Objectives: Cobalamin derivatives labeled with single photon emitters (In-111 and Tc-99) have shown promise in cancer detection in clinical trials. Development of the cobalamin-derived radiopharmaceuticals labeled with positron emitters is of interest due to the ability of positron emission tomography (PET) to provide quantitative information. We sought to prepare the DOTA-cyanocobalamin labeled with Cu-64 and test it in animal studies employing PET imaging. Methods: Cyanocobalamin-b-(4-aminobutyl)-amide-DOTA was synthesized. Chelation with commercially-available Cu-64 in the form of CuCl2 solution (Isotrace Inc., St.Louis, MO) was performed in acetate buffer at pH~5. Radiochemical composition and radiochemical purity of the final conjugate solution were assessed using TLC and C18 Sep-Pak methods respectively. Animal imaging study was performed under supervision of the IACUC. Three tumors were induced in two Wistar-Furth rats by the intraperitoneal injection of N-methyl-N-nitrosourea (NMU). Animals were anaesthetized and injected intravenously with 0.15ug/100 uCi of prepared Cu64-DOTA-cyanocobalamin. High resolution 10min PET images were repeatedly acquired with clinical PET scanner (PEM Flex PET, Naviscan PET Systems, Inc., San Diego, CA) from 10min to 3hrs post injection. PET images were reviewed, and tumor-to-background ratios were measured using region of interest tool. Results: Radiochemical purity of Cu64-DOTA-cyanocobalomin of 86% was achieved after 10 min of incubation time. “Cold” copper content in the starting Cu-64 solution limited the conjugate specific activity to ~0.7mCi/ug. Significant liver and kidney uptake was identified on the PET images, with notable gut activity after one hour post-injection. Brain and heart uptakes were unremarkable. All three chemically-induced tumors had enhanced signal on the PET images of experimental animals. Average measured tumor-to-background ratio was found to be 3.6 (range 2.9-4.8) in 30 min post-injection images and did not change significantly in 3 hours. Conclusions: DOTA-cyanocobalamin was successfully synthesized, labeled with Cu-64 and employed to detect chemically-induced tumors in experimental animals using PET imaging. Since Cu-64 is not ideal for the clinical practice, labeling of DOTA-cyanocobalamin with more appropriate positron-emitting radioisotopes is being pursued.
Structural and Functional Optical Imaging of Three-Dimensional Engineered Tissue Development (2004)

A significant amount of the data collected by cell biologists and tissue engineers relies on invasive imaging techniques to visualize dynamic structural and functional properties in engineered tissues. We report the use of optical coherence tomography and the comparative use of confocal microscopy to nondestructively and noninvasively monitor the structural and functional characteristics of three-dimensional engineered tissues over time. The engineered tissue model is composed of chitosan scaffolds and fibroblasts transfected with vinculin fused to green fluorescent protein. We image the developmental process of engineered tissues from changes of tissue microarchitecture to cell-matrix adhesions in three dimensions. These findings demonstrate the potential for optical coherence tomography in applications in cell and tissue biology, tissue engineering, and drug discovery.
Feedback effects in optical communication systems: characteristic curve for single-mode InGaAsP lasers (1992)

An experimental analysis of InGaAsP injection lasers shows an unexpected decrease of the differential quantum efficiency as a function of injected current when optical power is fed back into the active cavity of a diode inserted into a long transmission line. To investigate the response of laser diodes to optical feedback, we base our analysis on a microscopic model, resulting in a set of coupled equations that include the microscopic parameters that characterize the material and the device. This description takes into account the nonlinear dependence of the interband carrier lifetime on the level of optical feedback. Good agreement between the analytical description and experimental data is obtained for threshold current and differential quantum efficiency as functions of the feedback ratio.
(−)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinsonʼs disease (1997)

We have studied the effects of two D2 dopamine receptor-selective compounds, (-)-OSU 6162 and raclopride, on levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned common marmosets (Callithrix jacchus). Three monkeys developed a severe parkinsonian syndrome following administration of MPTP. In response to daily levodopa treatment the animals developed reproducible and idiosyncratic peak-dose dyskinesias. Pretreatment with (-)-OSU 6162 and raclopride, in doses increased by multiples of three, both dose-dependently relieved the levodopa-induced dyskinesias. However, in contrast to when raclopride pretreatment was given, (-)-OSU 6162 pretreatment did not induce akinesia. Our investigation suggests that (-)-OSU 6162 may be useful an an adjuvant treatment to levodopa in advanced Parkinson's disease to selectively combat levodopa-induced dyskinesias without affecting the antiparkinsonian response.
LEARNING,NETWORKFORMATION AND COORDINATION* (2000)

In many economic and social contexts, individual players choose their partners and also decide ona mode of behavior in interactions with these partners. This paper develops a simple model toexamine the interaction between partner choice and individual behavior in games of coordination.An important ingredient of our approach is the way we model partner choice: we suppose that aplayer can establish ties with other players by investing in costly pair-wise links.We show that individual efforts to balance the costs and benefits of links sharply restrict therange of stable interaction architectures; equilibrium networks are either complete or have the stararchitecture. Moreover, the process of network formation has powerful effects on individualbehavior: if costs of forming links are low then players coordinate on the risk-dominant action,while if costs of forming links are high then they coordinate on the efficient action.
Peningkatan Kemampuan Sosial Emosional Melalui Permainan Kolaboratif pada Anak Kelompok Bermain Tuanku Tambusai Tahun Ajaran 2017/2018 (2018)

Penelitian ini berawal dari temuan bahwa anak-anak pada Kelompok Bermain Tuanku Tambusai cenderung mengalami hambatan dalam perkembangan sosial emosionalnya. Pada observasi yang dilakukan terlihat anak belum bersedia bermain dengan teman sebaya dalam satu kelompok, anak masih menunjukkan sikap ego atau menang sendiri, anak tidak dapat menjalin kerja sama antar anggota kelompoknya, masih menunjukkan sikap saling berebut dalam bermain, dan anak tidak bertanggung jawab dalam melakukan tugasnya. Berdasarkan temuan tersebut peneliti bermaksud untuk mengembangkan kemampuan sosial emosional anak dengan penerapan permainan kolaboratif. Metode penelitian yang digunakan adalah penelitian tindakan. Metode dilakukan dengan menggunakan siklus model Kemmis dan Taggart yang terdiri dari 4 tahap (perencanaan, tindakan, observasi, dan refleksi).Data perkembangan sosial emosional anak dalam pembelajaran diperoleh dari observasi dan dokumentasi yang dianalisis dengan persentase. Penelitian dilakukan dua siklus, setiap siklus dilaksanakan dalam tiga kali pertemuan. Hasil penelitian menunjukkan melalui permainan kolaboratif dapat meningkatkan perkembangan sosial emosional pada anak-anak Kelompok Bermain Tuanku Tambusai.
Chemistry and Biochemistry of Branched‐Chain Sugars (1972)

Abstract Branched‐chain sugars have recently been isolated in larger numbers from microorganisms and higher plants as glycoside components of antibiotics or phenolic compounds. They also occur in plants in cell wall polysaccharides. Sugars with methyl, hydroxymethyl,formyl, hydroxyethyl, and glycoloyl branches have so far been found in nature. Many new methods have been developed for the synthesis of these sugars. With one exception, the branched sugars known at present can be divided biogenetically into three groups. Sugars with methyl branches are formed by C 1 transfer, sugars with hydroxyethyl branches by C 2 transfer to a hexose chain, and sugars with hydroxymethyl or formyl branches by rearrangement of a hexose or pentose chain.
NisT, the Transporter of the Lantibiotic Nisin, Can Transport Fully Modified, Dehydrated, and Unmodified Prenisin and Fusions of the Leader Peptide with Non-lantibiotic Peptides (2004)

Lantibiotics are lanthionine-containing peptide antibiotics. Nisin, encoded by nisA, is a pentacyclic lantibiotic produced by some Lactococcus lactis strains. Its thioether rings are posttranslationally introduced by a membrane-bound enzyme complex. This complex is composed of three enzymes: NisB, which dehydrates serines and threonines; NisC, which couples these dehydrated residues to cysteines, thus forming thioether rings; and the transporter NisT. We followed the activity of various combinations of the nisin enzymes by measuring export of secreted peptides using antibodies against the leader peptide and mass spectroscopy for detection. L. lactis expressing the nisABTC genes efficiently produced fully posttranslationally modified prenisin. Strikingly, L. lactis expressing the nisBT genes could produce dehydrated prenisin without thioether rings and a dehydrated form of a non-lantibiotic peptide. In the absence of the biosynthetic NisBC enzymes, the NisT transporter was capable of excreting unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. Our data show that NisT specifies a broad spectrum (poly)peptide transporter that can function either in conjunction with or independently from the biosynthetic genes. NisT secretes both unmodified and partially or fully posttranslationally modified forms of prenisin and non-lantibiotic peptides. These results open the way for efficient production of a wide range of peptides with increased stability or novel bioactivities.
Galactic globular clusters with extremely low metallicities. (1990)

An observational program has been initiated for determining chemical abundances of red giants belonging to galactic globular clusters, whose characteristics (morphology of the horizontal branch, integrated spectral type, ultraviolet excess, etc.) suggest extremely low metallicities. In this study we present some preliminary results obtained at Cerro Tololo Inter-American Observatory from Washington photometry of 165 red giants belonging to 15 globular clusters. The metallicities have been determined using a new empirical calibration recently established by Geisler, Clariá and Minniti (1990), which accounts for the effect of decreasing abundance sensitivity of Δ(C-M) with decreasing temperature. The mean [Fe/H] values obtained for 10 of the 15 clusters range between -2.0 and -3.0. Although preliminary, these values considerably extend the metallicity distribution of the galactic globular cluster system towards values close to -3.0, thus favoring the secondary formation theory of galactic globular clusters.
A Descriptive Framework for Electronic Meeting Systems Based on the UML Language (2002)

A descriptive framework has the purpose to identify the major components of a system and their relationships. This paper proposes a descriptive framework for electronic meeting systems. Our intention is to clarify and organize the conceptually and functionally distinctive components that we find in this technology. The proposed framework simplifies the evaluation of EMS functionality by organizations. The adoption of the UML language increases the potential of communicating EMS requirements to IS developers. The paper presents the evaluation grids of a collection of 10 EMS highlighting what framework components are supported and what components have been ignored
A 5 Gb/s monolithically integrated lightwave transmitter with 1.5 mu m multiple quantum well laser and HBT driver circuit (1991)

A multiple quantum well ridge waveguide laser at 1.5- mu m wavelength and a driver circuit comprised of four heterojunction bipolar transistors (HBTs) have been monolithically integrated on a semiinsulating InP substrate. This optoelectronic integrated circuit (OEIC) has been realized by metalorganic vapor phase epitaxy. The laser threshold current is near 20 mA. The HBT DC current gain is 40 and the unity gain cutoff frequency is 30 GHz. Pseudorandom pulsed operation of the OEIC transmitter has been demonstrated for bit rates up to 5 Gb/s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>