gebhart/patrepeval huggingface dataset:
Phase randomization for spatiotemporal averaging of unwanted interference effects arising from coherence (2018)

An approach to the reduction of unwanted interference effects, such as speckle and inhomogeneity, is to generate sequences of uncorrelated effects over the integration period of the sensor such that they are averaged. A moving diffuser is typically used. An innovative deformable mirror technology is presented as an alternative. Through phase randomization it achieves dynamic divergence of illumination without diffraction losses. It is shown to offer a unique combination of advantages over moving diffusers, including optical efficiency, speed, size, and reliability. Various applications are discussed.
Polynomial methods for component matching and verification (1998)

Component reuse requires designers to determine whether or not an e.risting component implements desired fimctionalip. ff a common structure is used to represent components that are described at multiple levels of abstraction, compan.sons between circuit specifications and a libra~of potential implementations can be peflormed quickly. A mechanism is presented for compactly specifying circuit flmctionality as polynomials at the word level. Polynomials can be used to represent circuits that are described at the bit level or arithmetically. Furthermore, in representing components as polynomials, differences in precision behveen potential implementations can be detected and quanti>ed.
A First Order Recursive Construction of Boolean Function with Optimum Algebraic Immunity. (2009)

Abstract. This paper proposed a first order recursive construction of Boolean function with optimum algebraic immunity. We also show that the Boolean functions are balanced and have good algebraic degrees.
<i>Leishmania</i> RNA Virus Controls the Severity of Mucocutaneous Leishmaniasis (2011)

Mucocutaneous leishmaniasis is caused by infections with intracellular parasites of the Leishmania Viannia subgenus, including Leishmania guyanensis. The pathology develops after parasite dissemination to nasopharyngeal tissues, where destructive metastatic lesions form with chronic inflammation. Currently, the mechanisms involved in lesion development are poorly understood. Here we show that metastasizing parasites have a high Leishmania RNA virus-1 (LRV1) burden that is recognized by the host Toll-like receptor 3 (TLR3) to induce proinflammatory cytokines and chemokines. Paradoxically, these TLR3-mediated immune responses rendered mice more susceptible to infection, and the animals developed an increased footpad swelling and parasitemia. Thus, LRV1 in the metastasizing parasites subverted the host immune response to Leishmania and promoted parasite persistence.
Evaluation of antiviral activity of essential oil of Trachyspermum Ammi against Japanese encephalitis virus (2015)

Our data indicate ajwain oil has potential in vitro antiviral activity against JEV. Further, the active biomolecule will be purified and evaluated for anti-JEV activity and also to scale up for in vivo trial to evaluate the efficacy of ajwain oil in future.
Neuropeptide Y mediates the initial hypothalamic–pituitary–adrenal response to maternal separation in the neonatal mouse (2008)

The function of the hypothalamic-pituitary-adrenal (HPA) axis of the neonatal mouse or rat is characterized by a period of quiescence, where mild stimuli are unable to elicit a pronounced increase in circulating corticosterone. A disruption of this period by maternal separation has been shown to result in a variety of long-term consequences, including neuroendocrine and behavioral disturbances. We have recently shown that peripheral metabolic markers like glucose or ghrelin are altered by maternal separation and that these changes precede the effects on corticosterone secretion. In the current study, we investigated whether the initial activation of the HPA axis is mediated via neuropeptide Y (NPY). To test this hypothesis, we studied the effects of an 8 h maternal separation in NPY-deficient mice. In addition, we compared the effect of the genotype with the previously described pharmacological effect of a ghrelin receptor antagonist. We could show that the peripheral response to maternal separation is decreased in NPY heterozygous and homozygous animals. In addition, maternal separation effects on corticotropin releasing hormone and glucocorticoid receptor expression in the brain were prevented in NPY-deficient pups. These effects were similar to a pharmacological ghrelin receptor blockade. We conclude that metabolic signals via an NPY-mediated pathway play a crucial role in activating the stress system of the neonatal mouse.
New insights into Fat cadherins (2005)

Cell-cell adhesion is fundamental to multicellular architecture. Several classes of adhesion molecule are used to achieve this, and cadherins represent a major family of such molecules. The cadherin family has multiple subfamilies. Members of the Fat cadherin subfamily, which is conserved across species, have an extraordinarily large extracellular region, comprising 34 repeated domains, making them the largest cadherin molecules. Classic Fat, identified in Drosophila, is known to regulate cell proliferation and planar cell polarity. Recent studies of one of its mammalian homologs, Fat1, have revealed novel functions of this molecule. Fat1 binds to Ena/VASP proteins and regulates actin dynamics at both cell-cell contacts and leading edges. These observations suggest that Fat1 is an important regulator of actin dynamics and controls cell-cell interactions through this activity.
The production of bioluminescent lactic acid bacteria suitable for the rapid assessment of starter culture activity in milk (1991)

Promoter elements from Lactobacillus casei were isolated with an Escherichia coli promoter probe vehicle and inserted 5′ to the luxA/B genes from Vibrio fischeri located within a pCK1‐based shuttle vector. Three independent promoter‐ lux constructs were each used to transform Lactobacillus casei, Lactococcus lactis and Lactococcus lactis subsp. diacetylactis by electroporation. Transformants of all three bacteria which expressed a bioluminescent phenotype in the presence of exogenous dodecanal were obtained. By virtue of monitoring changes in light production, these recombinant micro‐organisms could form the basis of a rapid monitoring system for antimicrobial substances in milk active against starter culture bacteria. In addition, the research potential of in vivo bioluminescence for monitoring gene expression in lactic acid bacteria in situ within fermentation systems can now be addressed.
Joint Virtual Switch Deployment and Routing for Load Balancing in SDNs (2018)

To better serve a diversity of flows, load balancing is crucial to ensure operational efficiency. However, previous works for load balancing have several disadvantages: 1) limited applicability with sub-flow scheduling (e.g., LetFlow); 2) hash collision (e.g., ECMP); or 3) transient network congestion due to reactive scheduling for traffic dynamics (e.g., Hedera and DevoFlow). An important reason for the above disadvantages is that it is difficult to provide fully fine-grained flow control for load balancing in an SDN as the flow table size of each SDN switch is usually limited. Inspired by the fact that a virtual switch (vswitch) has more powerful processing capacity and more flow entries compared with a physical switch, the previous work (e.g., Presto) deploys one vswitch for each ingress switch, and achieves the load balancing through efficient flow routing. However, this mechanism may lead to high cost and not well deal with topology asymmetry. Thus, this paper proposes to achieve the load balancing by incrementally deploying a certain number of vswitches in an SDN. We formulate the joint optimization of vswitch deployment and routing (JVR) problem as an integer linear program, and prove its NP-hardness. A rounding-based algorithm with bounded approximation factors is proposed to solve the JVR problem. We implement the proposed algorithm on an SDN testbed for experimental studies and use simulations for large-scale investigation. The experimental results and simulation results show high efficiency of our algorithm. For example, our proposed algorithm can reduce the link load ratio by about 41.5% compared with ECMP by deploying a small number of virtual switches.
Cadherin-6 Mediates the Heterotypic Interactions between the Hemopoietic Osteoclast Cell Lineage and Stromal Cells in a Murine Model of Osteoclast Differentiation (1998)

Osteoclasts are multinucleated cells of hemopoietic origin that are responsible for bone resorption during physiological bone remodeling and in a variety of bone diseases. Osteoclast development requires direct heterotypic cell-cell interactions of the hemopoietic osteoclast precursors with the neighboring osteoblast/stromal cells. However, the molecular mechanisms underlying these heterotypic interactions are poorly understood. We isolated cadherin-6 isoform, denoted cadherin-6/2 from a cDNA library of human osteoclast-like cells. The isolated cadherin-6/2 is 3,423 bp in size consisting of an open reading frame of 2,115 bp, which encodes 705 amino acids. This isoform lacks 85 amino acids between positions 333 and 418 and contains 9 different amino acids in the extracellular domain compared with the previously described cadherin-6. The human osteoclast-like cells also expressed another isoform denoted cadherin-6/1 together with the cadherin-6. Introduction of cadherin-6/2 into L-cells that showed no cell-cell contact caused evident morphological changes accompanied with tight cell-cell association, indicating the cadherin-6/2 we isolated here is functional. Moreover, expression of dominant-negative or antisense cadherin-6/2 construct in bone marrow-derived mouse stromal ST2 cells, which express only cadherin-6/2, markedly impaired their ability to support osteoclast formation in a mouse coculture model of osteoclastogenesis. Our results suggest that cadherin-6 may be a contributory molecule to the heterotypic interactions between the hemopoietic osteoclast cell lineage and osteoblast/bone marrow stromal cells required for the osteoclast differentiation. Since both osteoclasts and osteoblasts/bone marrow stromal cells are the primary cells controlling physiological bone remodeling, expression of cadherin-6 isoforms in these two cell types of different origin suggests a critical role of these molecules in the relationship of osteoclast precursors and cells of osteoblastic lineage within the bone microenvironment.
Brønsted acid-catalyzed α-halogenation of ynamides from halogenated solvents and pyridine-N-oxides (2017)

The keteniminium ions generated from the protonation of ynamides formed reversible adducts with counter anions and pyridine-N-oxides as well as halogenated solvents. Above 80 °C, the halonium ions selectively undergo a rate-limiting attack by pyridine-N-oxides, leading to (E)-haloenamides in good yields.
<scp>l</scp> -Arginine Supplementation in Peripheral Arterial Disease (2007)

In patients with PAD, long-term administration of L-arginine does not increase nitric oxide synthesis or improve vascular reactivity. Furthermore, the expected placebo effect observed in studies of functional capacity was attenuated in the L-arginine-treated group. As opposed to its short-term administration, long-term administration of L-arginine is not useful in patients with intermittent claudication and PAD.
Blue fluorescent amino acid for biological spectroscopy and microscopy (2017)

Many fluorescent proteins are currently available for biological spectroscopy and imaging measurements, allowing a wide range of biochemical and biophysical processes and interactions to be studied at various length scales. However, in applications where a small fluorescence reporter is required or desirable, the choice of fluorophores is rather limited. As such, continued effort has been devoted to the development of amino acid-based fluorophores that do not require a specific environment and additional time to mature and have a large fluorescence quantum yield, long fluorescence lifetime, good photostability, and an emission spectrum in the visible region. Herein, we show that a tryptophan analog, 4-cyanotryptophan, which differs from tryptophan by only two atoms, is the smallest fluorescent amino acid that meets these requirements and has great potential to enable in vitro and in vivo spectroscopic and microscopic measurements of proteins.
Neurotrophic Factor Protection against Excitotoxic Neuronal Death (1995)

Neurotrophic factors are polypeptides capable of promoting neuronal survival in both the developing and the adult brain. In addition to the neurotrophins, NGF, brain-derived neurotropic factor, and NT-3 to -6, other neurotrophic factors include ciliary neurotrophic factor, fibroblast growth factors, insulin-like growth factors, members of the transforming growth factor superfamily, members of the epidermal growth factor family, and other cytokines such as leukemia inhibitory factor, oncostatin M, and interleukins-6 and -11. One condition under which these factors promote survival is the challenge of neurons with analogs of excitatory amino acid transmitters. Such analogs, including quinolinic acid, kainic acid, and ibotenic acid, are frequently employed as models of neurological diseases such as Huntington's disease, Parkinson's disease, Alzheimer's disease, epilepsy, cerebellar degenerations, and amyotrophic lateral sclerosis. Excitotoxicity also plays a role in neu ronal death caused by focal ischemia, hypoglycemia, or trauma. Although much has been learned about the mechanisms of both the action of neurotrophic factors and of cell death in response to excitotoxins, the mechanism of protection by these factors remains uncertain. This review explores the biochemical and phys iological changes mediated by neurotrophic factors that may underlie their ability to protect against excito toxic cell death. Second messenger pathways used degenerately by both excitotoxins and neurotrophic factors are discussed as a potential site of interaction mediating the protective effects of neurotrophic factors. Particular attention is also paid to the importance of the route of neurotrophic factor delivery in conferring neuroprotection in particular excitotoxic models. The Neuroscientist 1:286-297, 1995
Concentration-Dependent Kinetics of Acetylcholinesterase Inhibition by the Organophosphate Paraoxon (2006)

For decades the interaction of the anticholinesterase organophosphorus compounds with acetylcholinesterase has been characterized as a straightforward phosphylation of the active site serine (Ser-203) which can be described kinetically by the inhibitory rate constant k(i). However, more recently certain kinetic complexities in the inhibition of acetylcholinesterase by organophosphates such as paraoxon (O,O-diethyl O-(p-nitrophenyl) phosphate) and chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) have raised questions regarding the adequacy of the kinetic scheme on which k(i) is based. The present article documents conditions in which the inhibitory capacity of paraoxon towards human recombinant acetylcholinesterase appears to change as a function of oxon concentration (as evidenced by a changing k(i)), with the inhibitory capacity of individual oxon molecules increasing at lower oxon concentrations. Optimization of a computer model based on an Ordered Uni Bi kinetic mechanism for phosphylation of acetylcholinesterse determined k(1) to be 0.5 nM(-1)h(-1), and k(-1) to be 169.5 h(-1). These values were used in a comparison of the Ordered Uni Bi model versus a k(i) model in order to assess the capacity of k(i) to describe accurately the inhibition of acetylcholinesterase by paraoxon. Interestingly, the k(i) model was accurate only at equilibrium (or near equilibrium), and when the inhibitor concentration was well below its K(d) (pseudo first order conditions). Comparisons of the Ordered Uni Bi and k(i) models demonstrate the changing k(i) as a function of inhibitor concentrations is not an artifact resulting from inappropriate inhibitor concentrations.
Graphene-Based Materials for Biosensors: A Review (2017)

The advantages conferred by the physical, optical and electrochemical properties of graphene-based nanomaterials have contributed to the current variety of ultrasensitive and selective biosensor devices. In this review, we present the points of view on the intrinsic properties of graphene and its surface engineering concerned with the transduction mechanisms in biosensing applications. We explain practical synthesis techniques along with prospective properties of the graphene-based materials, which include the pristine graphene and functionalized graphene (i.e., graphene oxide (GO), reduced graphene oxide (RGO) and graphene quantum dot (GQD). The biosensing mechanisms based on the utilization of the charge interactions with biomolecules and/or nanoparticle interactions and sensing platforms are also discussed, and the importance of surface functionalization in recent up-to-date biosensors for biological and medical applications.
Design of Statically Stable Walking Robot: A Review (2003)

Abstract The superior mobility characteristics of legged animals compared to those of wheeled or tracked vehicles for off‐road locomotion motivated the development of artificial walking machines. The sustained worldwide efforts for the last few decades resulted in a large number of legged robots with different levels of sophistication. Here, various design approaches made so far to realize artificial legged locomotion are discussed. Mainly, different vehicle configurations as well as leg mechanisms which are already explored by researchers are reviewed in brief. The author hopes that this will serve as a brief account of previous research efforts and help future walking robot designers to develop more sophisticated machines. © 2003 Wiley Periodicals, Inc.
Memory system characterization of big data workloads (2013)

Two recent trends that have emerged include (1) Rapid growth in big data technologies with new types of computing models to handle unstructured data, such as map-reduce and noSQL (2) A growing focus on the memory subsystem for performance and power optimizations, particularly with emerging memory technologies offering different characteristics from conventional DRAM (bandwidths, read/write asymmetries). This paper examines how these trends may intersect by characterizing the memory access patterns of various Hadoop and noSQL big data workloads. Using memory DIMM traces collected using special hardware, we analyze the spatial and temporal reference patterns to bring out several insights related to memory and platform usages, such as memory footprints, read-write ratios, bandwidths, latencies, etc. We develop an analysis methodology to understand how conventional optimizations such as caching, prediction, and prefetching may apply to these workloads, and discuss the implications on software and system design.
Development and Validation of Fiber Model for High-Strength Square Concrete-Filled Steel Tube Beam-Columns (2005)

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A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype (2002)

Idiopathic hyperphosphatasia is an autosomal recessive bone disease characterized by deformities of long bones, kyphosis and acetabular protrusion, increasing in severity as affected children pass through adolescence. Biochemical and histological evidence indicate that there is extremely rapid bone turnover, with indices of both bone resorption and formation greatly increased. A genome-wide search, in a family with three children affected by idiopathic hyperphosphatasia, suggested linkage to a locus on the long arm of chromosome 8 (8q24). The gene TNFRSF11B encoding osteoprotegerin (OPG), which lies within this locus, was an obvious candidate, given the critical role of OPG in regulating osteoclast development. All three affected siblings were homozygous for a 3 bp inframe deletion in exon 3 of the TNFRSF11B gene, resulting in the loss of an aspartate residue. Their parents (who were first cousins) were heterozygous for the mutation. Recombinant wild-type and mutant OPG cDNAs were expressed in human epithelial kidney cells, and secreted OPG was collected from the conditioned medium. In vitro measurements of bone resorption showed that wild-type OPG suppressed bone resorption, whereas the mutant form did not, confirming this to be an inactivating mutation. This description of abnormal OPG function in humans expands the spectrum of genetic bone diseases arising from perturbations of the OPG/RANK-L/RANK system that regulates osteoclastogenesis.
Malaria: progress, perils, and prospects for eradication (2008)

There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of anti-mosquito measures and new artemisinin-containing treatments, prompting renewed calls for global eradication. However, treatment and mosquito control currently depend on too few compounds and thus are vulnerable to the emergence of compound-resistant parasites and mosquitoes. As discussed in this Review, new drugs, vaccines, and insecticides, as well as improved surveillance methods, are research priorities. Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions.
Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages. (2002)

Resveratrol and ethanol can interact to influence the production of macrophage function molecules, which is noteworthy in evaluating the health-care effect of wine consumption.
Built-in test of CMOS state machines with realistic faults: a system perspective (1990)

The design of built-in test systems for large arrays is approached from the viewpoint of detecting real faults in the mask layers of a typical CMOS process. The resulting testable design and built-in test system provides a practical compromise between the costly hardware augmentation plaguing existing techniques and circuit independence of the test procedure. Built-in testability is achieved independently of feedback. Therefore, combinational and sequential circuits can be tested in parallel with exactly the same hardware and method. The test-specific hardware overhead decreases rapidly with increasing circuit size and falls below 10% for large arrays with more than 100 product terms. No additional gate delays are introduced into the critical path by the test circuitry. The normal circuit performance is, therefore, left intact with the exception of a minimal degradation associated with adding tristate capability to the input buffers.
Towards Distributed Clouds (2018)

This review focuses on the evolution of cloud computing and distributed ledger technologies (blockchains) over the last decade. Cloud computing relies mainly on a conceptually centralized service provisioning model, while blockchain technologies originate from a peer-to-peer and a completely distributed approach. Still, noteworthy commonalities between both approaches are often overlooked by researchers. Therefore, to the best of the authors knowledge, this paper reviews both domains in parallel for the first time. We conclude that both approaches have advantages and disadvantages. The advantages of centralized service provisioning approaches are often the disadvantages of distributed ledger approaches and vice versa. It is obviously an interesting question whether both approaches could be combined in a way that the advantages can be added while the disadvantages could be avoided. We derive a software stack that could build the foundation unifying the best of these two worlds and that would avoid existing shortcomings like vendor lock-in, some security problems, and inherent platform dependencies.