gebhart/patrepeval huggingface dataset:
Isolation of <i>l</i>-3:4-dihydroxyphenylalanine from the seeds of <i>Mucuna pruriens</i> (1937)

Research Article| December 01 1937 Isolation of l-3:4-dihydroxyphenylalanine from the seeds of Mucuna pruriens Manayath Damodaran; Manayath Damodaran 1The University Biochemical Laboratory, Chepauk, Madras Search for other works by this author on: This Site PubMed Google Scholar Raghaviah Ramaswamy Raghaviah Ramaswamy 1The University Biochemical Laboratory, Chepauk, Madras Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1937) 31 (12): 2149–2152. https://doi.org/10.1042/bj0312149 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation Manayath Damodaran, Raghaviah Ramaswamy; Isolation of l-3:4-dihydroxyphenylalanine from the seeds of Mucuna pruriens. Biochem J 1 December 1937; 31 (12): 2149–2152. doi: https://doi.org/10.1042/bj0312149 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1937 CAMBRIDGE UNIVERSITY PRESS1937 Article PDF first page preview Close Modal You do not currently have access to this content.
The Phosphoenolpyruvate Phosphotransferase System Regulates <i>Vibrio cholerae</i> Biofilm Formation through Multiple Independent Pathways (2010)

The bacterial phosphoenolpyruvate phosphotransferase system (PTS) is a highly conserved phosphotransfer cascade that participates in the transport and phosphorylation of selected carbohydrates and modulates many cellular functions in response to carbohydrate availability. It plays a role in the virulence of many bacterial pathogens. Components of the carbohydrate-specific PTS include the general cytoplasmic components enzyme I (EI) and histidine protein (HPr), the sugar-specific cytoplasmic components enzymes IIA (EIIA) and IIB (EIIB), and the sugar-specific membrane-associated multisubunit components enzymes IIC (EIIC) and IID (EIID). Many bacterial genomes also encode a parallel PTS pathway that includes the EI homolog EI(Ntr), the HPr homolog NPr, and the EIIA homolog EIIA(Ntr). This pathway is thought to be nitrogen specific because of the proximity of the genes encoding this pathway to the genes encoding the nitrogen-specific sigma factor sigma(54). We previously reported that phosphorylation of HPr and FPr by EI represses Vibrio cholerae biofilm formation in minimal medium supplemented with glucose or pyruvate. Here we report two additional PTS-based biofilm regulatory pathways that are active in LB broth but not in minimal medium. These pathways involve the glucose-specific enzyme EIIA (EIIA(Glc)) and two nitrogen-specific EIIA homologs, EIIA(Ntr1) and EIIA(Ntr2). The presence of multiple, independent biofilm regulatory circuits in the PTS supports the hypothesis that the PTS and PTS-dependent substrates have a central role in sensing environments suitable for a surface-associated existence.
Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes (1992)

The purpose of our study was to compare the therapeutic effects of doxorubicin in 3 different formulations: (1) in PBS, (2) in conventional liposomes composed of egg phosphatidylglycerol/egg phosphatidylcholine/cholesterol/dl-alpha tocopherol, and (3) in sterically stabilized, long-circulating "Stealth" liposomes composed of hydrogenated soy phosphatidylcholine/cholesterol/polyethylene glycol-distearoylphosphatidylethanolamine. The doxorubicin formulations were used to treat recently implanted and well-established, growing primary mouse mammary carcinomas, and to inhibit the development of spontaneous metastases from intra-mammary tumor implants. In the treatment of recently implanted primary tumors, the formulations were given in 3 i.v. injections over 15 days, starting 3 or 10 days after tumor implantation. In the treatment of well-established primary tumors, the mice received 4 i.v. injections over 22 days, starting an average 38 days after tumor implantation. In the preventive treatment against metastases, the formulations were given in 4 i.v. injections over 22 days, starting 22 days or 58 days after primary tumor implantation. The Stealth liposome formulation was significantly more effective than the conventional liposome formulation or the free drug in reducing the incidence of metastases from intra-mammary implants of tumor MC19 and tumor MC65, in curing mice with recent implants of tumor MC2A, tumor MC2B, and tumor MC65, and in increasing the 8-week survival of mice with well-established implants of tumor MC2B. It is concluded that the long circulation time of the Stealth liposome doxorubicin formulation accounts for its superior therapeutic effectiveness.
Biogas pre-upgrading by adsorption of trace compounds onto granular activated carbons and an activated carbon fiber-cloth (2009)

The study assesses the adsorption onto activated carbon materials of selected volatile organic compounds -VOCs- (dichloromethane, 2-propanol, toluene, siloxane D4) in a biogas matrix composed of methane and carbon dioxide (55:45 v/v). Three different adsorbents are tested, two of them are granular activated carbon (GAC), and the last is an activated carbon fiber-cloth (ACFC). The adsorption isotherm data are fitted by different models by nonlinear regression. The Langmuir-Freundlich model appears to be the adequate one to describe the adsorption phenomena independently of the VOC considered or the adsorbent. The adsorbents present attractive adsorption capacity of the undesirable compounds in biogas atmosphere though the maximum adsorption capacities for a VOC are quite different from each other. The adsorption kinetics are characterized through three coefficients: the initial adsorption coefficient, the external film mass transfer coefficient and the internal diffusion coefficient of Weber. The ACFC demonstrates advanced kinetic yields compared to the granular activated carbon materials whatever VOC is considered. Therefore, pre-upgrading of biogas produced from wastewater sludge or co-digestion system by adsorption onto activated carbon appears worth investigating. Especially with ACFC material that presents correct adsorption capacities toward VOCs and concrete regeneration process opportunity to realize such process.
The Herpes Simplex Virus 1 U <sub>S</sub> 3 Protein Kinase Blocks Caspase-Dependent Double Cleavage and Activation of the Proapoptotic Protein BAD (2003)

An earlier report showed that the U(S)3 protein kinase blocked the apoptosis induced by the herpes simplex virus 1 (HSV-1) d120 mutant at a premitochondrial stage. Further studies revealed that the kinase also blocks programmed cell death induced by the proapoptotic protein BAD. Here we report the effects of the U(S)3 protein kinase on the function and state of a murine BAD protein. Specifically, (i) in uninfected cells, BAD was processed by at least two proteolytic cleavages that were blocked by a general caspase inhibitor. The untreated transduced cells expressed elevated caspase 3 activity. (ii) In cells cotransduced with the U(S)3 protein kinase, the BAD protein was not cleaved and the caspase 3 activity was not elevated. (iii) Inasmuch as the U(S)3 protein kinase blocked the proapoptotic activity and cleavage of a mutant (BAD3S/A) in which the codons for the regulatory serines at positions 112, 136, and 155 were each replaced with alanine codons, the U(S)3 protein kinase does not act by phosphorylation of these sites nor was the phosphorylation of these sites required for the antiapoptotic function of the U(S)3 protein kinase. (iv) The U(S)3 protein kinase did not enable the binding of the BAD3S/A mutant to the antiapoptotic proteins 14-3-3. Finally, (v) whereas cleavage of BAD at ASP56 and ASP61 has been reported and results in the generation of a more effective proapoptotic protein with an M(r) of 15,000, in this report we also show the existence of a second caspase-dependent cleavage site most likely at the ASP156 that is predicted to inactivate the proapoptotic activity of BAD. We conclude that the primary effect of U(S)3 was to block the caspases that cleave BAD at either residue 56 or 61 predicted to render the protein more proapoptotic or at residue 156, which would inactivate the protein.
Very high long-term stability synchroscan streak camera (2003)

In this article, we present the drifts phenomena that affect the temporal resolution of a standard synchroscan streak camera and some techniques to correct them in order to enhance the long-term resolution of these cameras. First, we give a comprehensive list of the components of the synchroscan streak camera which are sensitive to temporal and thermal drift: from the trigger circuit to the deflection plate of the tube. The way in which these components make the camera drift is explained and then quantified. A measure of drift realized on two streak cameras at the same time and in the same conditions (the same synchroscan signal) shows that each camera has its own intrinsic and stochastic drift. Second, two techniques to stabilize the camera are then described. The first method stabilizes the phase difference between the synchroscan signal and the deflection plate voltage. The second uses a laser reference trace on the phosphor screen and a digital data processing technique to reach the ultimate stability. The results show that a stabilized camera can be used immediately after it is turned on (due to suppression of the warm-up time) and still has very good temporal resolution even with a long-time exposure (2.4 ps full width at half maximum with a time exposure of 2 h has been achieved). This allows more exploration in the detection of very weak signals.
Robust Computation of Linear Models, or How to Find a Needle in a Haystack (2012)

Consider a dataset of vector-valued observations that consists of noisy inliers, which are explained well by a low-dimensional subspace, along with some number of outliers.This work describes a convex optimization problem, called REAPER, that can reliably fit a low-dimensional model to this type of data.This approach parameterizes linear subspaces using orthogonal projectors, and it uses a relaxation of the set of orthogonal projectors to reach the convex formulation.The paper provides an efficient algorithm for solving the REAPER problem, and it documents numerical experiments which confirm that REAPER can dependably find linear structure in synthetic and natural data.In addition, when the inliers lie near a low-dimensional subspace, there is a rigorous theory that describes when REAPER can approximate this subspace.
Polymerization of Purified Yeast Septins: Evidence That Organized Filament Arrays May Not Be Required for Septin Function (1998)

The septins are a family of proteins required for cytokinesis in a number of eukaryotic cell types. In budding yeast, these proteins are thought to be the structural components of a filament system present at the mother-bud neck, called the neck filaments. In this study, we report the isolation of a protein complex containing the yeast septins Cdc3p, Cdc10p, Cdc11p, and Cdc12p that is capable of forming long filaments in vitro. To investigate the relationship between these filaments and the neck filaments, we purified septin complexes from cells deleted for CDC10 or CDC11. These complexes were not capable of the polymerization exhibited by wild-type preparations, and analysis of the neck region by electron microscopy revealed that the cdc10Delta and cdc11Delta cells did not contain detectable neck filaments. These results strengthen the hypothesis that the septins are the major structural components of the neck filaments. Surprisingly, we found that septin dependent processes like cytokinesis and the localization of Bud4p to the neck still occurred in cdc10Delta cells. This suggests that the septins may be able to function in the absence of normal polymerization and the formation of a higher order filament structure.
The design of a real-time communication network for parallel processing (2002)

A novel dynamic interconnection network for parallel processing systems is presented. During task execution, process-to-process communications are measured. On the basis of these measurements an optimal network topology is derived. By introducing a network priority, real-time applications can be supported. The total communication time is minimized. The network structure is hidden to the user. A communication between two processes only requires an identification of the source and the destination process. The user is provided a virtual network. All routing computations are performed by the network, thus not placing a load on the processors. In addition, the network completely controls itself. Therefore, no processor time is requested for network computations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Natural movement: or, configuration and attraction in urban pedestrian movement (1993)

Existing theories relating patterns of pedestrian and vehicular movement to urban form characterise the problem in terms of flows to and from â€˜attractorâ€™ land uses. This paper contains evidence in support of a new â€˜configurationalâ€™ paradigm in which a primary property of the form of the urban grid is to privilege certain spaces over others for through movement. In this way it is suggested that the configuration of the urban grid itself is the main generator of patterns of movement. Retail land uses are then located to take advantage of the opportunities offered by the passing trade and may well act as multipliers on the basic pattern of â€˜natural movementâ€™ generated by the grid configuration. The configurational correlates of movement patterns are found to be measures of global properties of the grid with the â€˜space syntaxâ€™ measure of â€˜integrationâ€™ consistently found to be the most important. This has clear implications for urban design suggesting that if we wish to design for well used urban space, then it is not the local properties of a space that are important in the main but its configurational relations to the larger urban system.
An analytical approach to floorplan design and optimization (1990)

An analytical method for general floorplan design and optimization is proposed. This method is based on a mixed integer programming model and application of a standard mathematical software. The method allows arbitrary combinations of rigid and flexible modules. Various objective functions such as chip area, interconnection length, timing delays or any combinations of them are permitted. Routing space is estimated by the global router. Experimental data are provided.
Data Structures and Genetic Programming (1995)

In real world applications, software engineers recognise the use of memory must be organised via data structures and that software using the data must be independant of the data structures’ implementation details. They achieve this by using abstract data structures, such as records, files and buffers. We demonstrate that genetic programming can automatically implement simple abstract data structures, considering in detail the task of evolving a list. We show general and reasonably efficient implementations can be automatically generated from simple primitives. A model for maintaining evolved code is demonstrated using the list problem. 4 page early abstract at http://www.cs.ucl.ac.uk/staff/W.Langdon/ftp/papers/GPlist_aigp2.ps
A compact planar inverted-f antenna with a pbg-type ground plane for mobile communications (2003)

The ground plane affects the characteristics of a planar inverted-F antenna (PIFA) significantly. Using the idea of the high-impedance surface to construct the ground plane, a new type of compact PIFA with a photonic bandgap type (PBG-type) ground plane is proposed. Both the traditional PIFA and the proposed antenna are analyzed using the finite-difference time-domain (FDTD) method in detail. It is found that the two antennas have similar directivity pattern characteristics, but the size of the latter can be reduced obviously. The results also show that the bandwidth of a traditional PIFA is not greatly affected by the thickness of the metallic ground plane and that the shapes of the directivity patterns are not greatly affected by the ground plane under the small size condition. The operating-frequency band of the proposed antenna can be adjusted by changing the dielectric substrate thickness of the ground plane. They are suitable for mobile communication applications.
Adaptive Cluster Throttling: Improving High-Load Performance in Bufferless On-Chip Networks (2011)

Higher core counts and increasing focus on energy efficiency in modern Chip Multiprocessors (CMP) have led to renewed interest in simple and energy-efficient Network-on-Chip (NoC) designs. Several recent proposed designs trade off network capacity for efficiency, based on the observation that traditional networks are overprovisioned for many workloads. Bufferless routing is one such example. However, when the application workload requires high interconnect performance, the inefficiencies of bufferless interconnects can cause significant performance degradations. Previous work has tackled various issues with buffer-less routing, but little work has been done to improve performance at high network load. Fundamental improvements in bufferless network performance at high load could extend the benefits of lower energy and smaller die area to a wider range of potential applications. In this work, we propose ACT (Adaptive Cluster Throttling), a source-throttling mechanism that provides better system performance and fairness than the best current mechanisms on bufferless networks. By batching applications into clusters, and alternately throttling different clusters, ACT provides a chance for all applications to inject traffic into the network while maintaining control over total network load. We show 11.9 % (10.2%) system performance gain on average with 14.5 % (15.1%) improvement in fairness over 60 network-intensive workloads on a 4x4 (8x8) bufferless NoC. At high network load, ACT achieves nearly half the performance gain over a bufferless baseline that a conventional buffered network achieves, while reducing network power by 15.4 % (5.4%). 1
The application of space-time ARIMA model on traffic flow forecasting (2009)

Traffic flow data are in the form of spatial time series and are collected at specific locations at constant intervals of time. Space-time autoregressive time series modeling is a promising inductive method that uses a small number of parameters and can be used for online monitoring and prediction. In this paper, we develop space-time autoregressive models for urban traffic flow network scenarios. We evaluate the ability of the space-time autoregressive models to model the spatial and temporal correlations in the traffic network and show that the space-time model performs well.
Las 36 ediciones del "Antonio" en vida del autor (1987)

OSTA may be reliably used as a screening tool for women at high risk of osteoporosis across India and may circumvent the limited availability of DXA scanners across the country.
Stiff macromolecules with aliphatic side chains: side-chain mobility, conformation, and organization from 2D solid-state NMR spectroscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStiff macromolecules with aliphatic side chains: side-chain mobility, conformation, and organization from 2D solid-state NMR spectroscopyJ. Clauss, K. Schmidt-Rohr, A. Adam, C. Boeffel, and H. W. SpiessCite this: Macromolecules 1992, 25, 20, 5208–5214Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ma00046a015https://doi.org/10.1021/ma00046a015research-articleACS PublicationsRequest reuse permissionsArticle Views654Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Best-First Heuristic Search for Multicore Machines (2010)

To harness modern multicore processors, it is imperative to develop parallel versions of fundamental algorithms. In this paper, we compare different approaches to parallel best-first search in a shared-memory setting. We present a new method, PBNF, that uses abstraction to partition the state space and to detect duplicate states without requiring frequent locking. PBNF allows speculative expansions when necessary to keep threads busy. We identify and fix potential livelock conditions in our approach, proving its correctness using temporal logic. Our approach is general, allowing it to extend easily to suboptimal and anytime heuristic search. In an empirical comparison on STRIPS planning, grid pathfinding, and sliding tile puzzle problems using 8-core machines, we show that A*, weighted A* and Anytime weighted A* implemented using PBNF yield faster search than improved versions of previous parallel search proposals.