gebhart/patrepeval huggingface dataset:
Adaptive demand-driven multicast routing in multi-hop wireless ad hoc networks (2001)

The use of on-demand techniques in routing protocols for multi-hop wireless ad hoc networks has been shown to have significant advantages in terms of reducing the routing protocol's overhead and improving its ability to react quickly to topology changes in the network. A number of on-demand multicast routing protocols have been proposed, but each also relies on significant periodic (non-on-demand) behavior within portions of the protocol. This paper presents the design and initial evluation of the Adaptive Demand-Driven Multicast Routing protocol (ADMR), a new on-demand ad hoc network multicast routing protocol that attemps to reduce as much as possible any non-on-demand components within the protocol. Multicast routing state is dynamically established and maintained only for active groups and only in nodes located between multicast senders and receivers. Each multicast data packet is forwarded along the shortest-delay path with multicast forwarding state, from the sender to the receivers, and receivers dynamically adapt to the sending pattern of senders in order to efficiently balance overhead and maintenance of the multicast routing state as nodes in the network move or as wireless transmission conditions in the network change. We describe the operation of the ADMR protocol and present an initial evaluation of its performance based on detailed simulation in ad hoc networks of 50 mobile nodes. We show that ADMR achieves packet delivery ratios within 1% of a flooding-based protocol, while incurring half to a quarter of the overhead.
GCRP: geographic virtual circuit routing protocol for ad hoc networks (2005)

Geographic routing exploits localized information concerning explicit node locations to make forwarding decisions. This approach adapts well to the dynamic nature of ad hoc networks. However it is subject to increased overhead during the local minimum recovery process. In this paper we specify GCRP a routing protocol based on the novel geocircuit paradigm, that exploits already discovered paths to avoid repeated recoveries from the same local minimums. The proposed protocol is established to exhibit loop-freedom, while robustly eliminating mobility-induced loops. Performance analysis demonstrates significant advantage of GCRP relative to conventional geogram routing, over a wide range of network environment conditions. Gains increase as limiting network parameters are increased, namely node mobility, traffic load, network size and density. Effective repair of broken geocircuits preserves scalability in highly mobile environments.
Lomustine, etoposide, vindesine, and dexamethasone (CEVD) in Hodgkin's lymphoma refractory to cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) and doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD): a multicenter trial of the German Hodgkin Study Group. (1987)

Thirty-two patients with advanced Hodgkin's lymphoma resistant to cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) and doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) were treated with a salvage chemotherapy regimen consisting of lomustine, etoposide, vindesine, and dexamethasone (CEVD). Twenty-seven patients were treated because of primary resistance to COPP/ABVD, and five patients were treated in early relapse (less than 12 months) after COPP/ABVD-induced complete remission. Fourteen patients (44%) achieved complete remission, and four patients achieved partial remission, with an overall response rate of 56%. Two partial responders achieved complete remission after additional radiotherapy. Four of five patients in early relapse after COPP/ABVD achieved complete remission. Consolidation radiotherapy was given for only one complete responder. Median duration of complete remission is greater than 10 months, and median survival is greater than 26 months. The treatment was well-tolerated. The main side effects were leukopenia, thrombocytopenia, mild nausea/vomiting, and cushingoid side effects. CEVD is a very active and well-tolerated salvage chemotherapy regimen in patients with Hodgkin's disease resistant to or relapsing after COPP and ABVD.
Blood Flow through Human Adipose Tissue Determined with Radioactive Xenon (1966)

Abstract The disappearance rate of an injected depot of radioactive Xenon dissolved in saline has been used to measure the blood flow through human adipose tissue according to the tissue clearance principle of Kety. The technical details regarding the injection and radioactivity measurement are described and the theoretical implications of the use of local clearance methods in general are discussed. The study comprised 69 examinations of 17 men and 38 women in various states of nutrition. The average blood flow, as measured in the abdominal fatty tissue, was 2.6 ml/100 g. min with a standard deviation of 1.7, and it was found to decrease significantly with increasing thickness of the fatty tissue.
Synthesis from Examples (2012)

Examples are often a natural way to specify computational structures such as programs, queries, and sequences. Synthesizing such structures from example based specification has applications in automating end-user programming and in building intelligent tutoring systems. Synthesis from examples involves addressing two key technical challenges: (i) design of an efficient search algorithm – these algorithms have been based on various paradigms including versionspace algebras, SAT/SMT solvers, numerical methods, and even exhaustive search, (ii) design of a user interaction model to deal with the inherent ambiguity in the example based specification. This paper illustrates various algorithmic techniques and user interaction models by describing inductive synthesizers for varied applications including synthesis of tricky bitvector algorithms, spreadsheet macros for automating repetitive data manipulation tasks, ruler/compass based geometry constructions, new algebra problems, sequences for mathematical intellisense, and grading of programming problems. 1.
ChemInform Abstract: SOME REACTIONS OF 1‐LITHIO‐2‐N‐BUTYL‐1,2‐DIHYDROPYRIDINE. VI. SYNTHESIS OF β‐SUBSTITUTED PYRIDINES (1976)

Abstract 1‐Lithio‐2‐butyl‐l ,2‐dihydropyridin (I) wird mit verschiedenen elektrophilen Reagentien umgesetzt.
Stress signaling by Tec tyrosine kinase in the ischemic myocardium (2010)

Nonreceptor tyrosine kinases have an increasingly appreciated role in cardiac injury and protection. To investigate novel tasks for members of the Tec family of nonreceptor tyrosine kinases in cardiac phenotype, we examined the behavior of the Tec isoform in myocardial ischemic injury. Ischemia-reperfusion, but not cardiac protective agents, induced altered intracellular localization of Tec, highlighting distinct actions of this protein compared with other isoforms, such as Bmx, in the same model. Tec is abundantly expressed in cardiac myocytes and assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP. To characterize Tec signaling targets in vivo, we performed an exhaustive proteomic analysis of Tec-binding partners. These experiments expand the role of the Tec family in the heart, identifying the Tec isoform as an ischemic injury-induced isoform, and map the subproteome of its interactors in isolated cells.
Using complexity metrics with R-R intervals and BPM heart rate measures (2013)

Lately, growing attention in the health sciences has been paid to the dynamics of heart rate as indicator of impending failures and for prognoses. Likewise, in social and cognitive sciences, heart rate is increasingly employed as a measure of arousal, emotional engagement and as a marker of interpersonal coordination. However, there is no consensus about which measurements and analytical tools are most appropriate in mapping the temporal dynamics of heart rate and quite different metrics are reported in the literature. As complexity metrics of heart rate variability depend critically on variability of the data, different choices regarding the kind of measures can have a substantial impact on the results. In this article we compare linear and non-linear statistics on two prominent types of heart beat data, beat-to-beat intervals (R-R interval) and beats-per-min (BPM). As a proof-of-concept, we employ a simple rest-exercise-rest task and show that non-linear statistics-fractal (DFA) and recurrence (RQA) analyses-reveal information about heart beat activity above and beyond the simple level of heart rate. Non-linear statistics unveil sustained post-exercise effects on heart rate dynamics, but their power to do so critically depends on the type data that is employed: While R-R intervals are very susceptible to non-linear analyses, the success of non-linear methods for BPM data critically depends on their construction. Generally, "oversampled" BPM time-series can be recommended as they retain most of the information about non-linear aspects of heart beat dynamics.
Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism (2011)

Chikungunya virus (CHIKV) is a reemerging mosquito-borne pathogen that has recently caused devastating urban epidemics of severe and sometimes chronic arthralgia. As with most other mosquito-borne viral diseases, control relies on reducing mosquito populations and their contact with people, which has been ineffective in most locations. Therefore, vaccines remain the best strategy to prevent most vector-borne diseases. Ideally, vaccines for diseases of resource-limited countries should combine low cost and single dose efficacy, yet induce rapid and long-lived immunity with negligible risk of serious adverse reactions. To develop such a vaccine to protect against chikungunya fever, we employed a rational attenuation mechanism that also prevents the infection of mosquito vectors. The internal ribosome entry site (IRES) from encephalomyocarditis virus replaced the subgenomic promoter in a cDNA CHIKV clone, thus altering the levels and host-specific mechanism of structural protein gene expression. Testing in both normal outbred and interferon response-defective mice indicated that the new vaccine candidate is highly attenuated, immunogenic and efficacious after a single dose. Furthermore, it is incapable of replicating in mosquito cells or infecting mosquitoes in vivo. This IRES-based attenuation platform technology may be useful for the predictable attenuation of any alphavirus.
Novel microstrip bandpass filters based on complementary split-ring resonators (2006)

In this paper, a new methodology for the design of compact planar filters in microstrip technology is proposed. This is based on cascading filter stages consisting of the combination of complementary split-ring resonators (CSRRs), recently proposed by the authors, series capacitive gaps, and grounded stubs. By this means, we achieve the necessary flexibility to simultaneously obtain quite symmetric frequency responses, controllable bandwidths, and compact dimensions. Two prototype device bandpass filters are provided to illustrate the potentiality of the proposed approach. In the first prototype, the structure is periodic (i.e., composed of identical cells) and behaves as a left-handed transmission line with controllable bandwidth. In the second prototype device, periodicity is sacrificed with an eye toward the synthesis of a standard (Chebyshev) approximation. The measured frequency responses point out low insertion losses in the passband, as well as high-frequency selectivity with small dimensions. As compared to conventional parallel coupled line filters, reduction of device length by a factor of 2.4 is demonstrated. This is the first time that planar filters with controllable bandwidth based on CSRRs are achieved. These structures can be of interest in those applications where miniaturization and compatibility with planar circuit technology are key issues
Development of cultural capital content for regional promotion and local exhibitions (2014)

The aim of our research project is to construct 'cultural capital content' that makes people rediscover valuable art works in their own localities and bring the benefits of regional promotions. We have already developed the digital content of an old picture scroll of 'Landscapes of Osaka along the Yodo River (Shunboku, 1745)' using ultra-high resolution images and have presented some content with its high quality replica [Hayashi, 2014]. The present research reports on further development of interactive content for the practice of exhibitions in Osaka, Japan.
Fabrication of 3D nanoimprint stamps with continuous reliefs using dose-modulated electron beam lithography and thermal reflow (2010)

3D electron beam lithography and thermal reflow were combined to fabricate structures with multilevel and continuous profiles. New shapes, smooth surfaces and sharp corners were achieved. By using exposure with variable doses, up to 20 steps were fabricated in a 500 nm thick resist with a lateral resolution of 200 nm. Steps were reflowed into continuous slopes by thermal post-processing, and were transferred into silicon substrates by proportional plasma etching. The method can be used for the fabrication of 3D nanoimprint stamps with both sharp features and continuous profiles.
Agent-based modeling and simulation of the decision behaviors of e-retailers (2018)

Purpose Social media facilitates consumer exchanges on product opinions and provides comprehensive knowledge of online products. The interaction between consumers and e-retailers evolves into a collective set of dynamics within a complex system. Agent-based modeling is well suited to stimulate such complex systems. The purpose of this paper is to integrate agent-based model and technique for order performance by similarity to ideal solution (TOPSIS) to simulate decision behaviors of e-retailers in competitive online markets. Design/methodology/approach An agent-based network model using the TOPSIS driven by actual price data is developed. The authors ran an experimental model to simulate interactions between online consumers and e-retailers and to record simulation data. A nonparametric test is used to conduct data analysis and evaluate the sensibility of parameters. Findings Simulation results showed that different profits could be obtained for various brands under different social network structures. E-retailers could achieve more profits through cross-selling than single-selling; however, the highest profits can be achieved when some adopt cross-selling, whereas others use single-selling. From a game perspective, the equilibrium for price-adjustment frequency can be determined from the simulation data. Thus, price adjustment differences significantly affect e-retailer profit. Originality/value This study provides new insights into the evolutionary dynamics of online markets. This work also indicates how to build an integrated simulation model with an agent-based model and TOPSIS and how to use an integrated simulation model and interpret its results.
Oncogenic Remodeling of the Three-Dimensional Organization of the Interphase Nucleus: c-Myc Induces Telomeric Aggregates Whose Formation Precedes Chromosomal Rearrangements (2005)

The three-dimensional (3D) organization of the normal interphase nucleus permits the regulated completion of transcription and replication and assures proper chromosome organization. Aberrations from the normal 3D structural order of the nucleus are found in tumor cells. When examining the 3D organization of telomeres in nuclei of normal and tumor cells, we found that telomeres of normal nuclei do not overlap, while telomeres of tumor cells form aggregates of various numbers and sizes. To understand how such changes occur and what their implications are we have recently examined the role of the oncoprotein c-Myc in inducing changes in the 3D nuclear organization of telomeres. We found that c-Myc remodels the organization of telomeres and chromosomes in the interphase nucleus. It induces the formation of telomeric aggregates and fusions that are followed by breakage-bridge fusion cycles, and lead to the onset of chromosomal rearrangements that are typical of tumor cells.
Effect of an allergy prevention programme on incidence of atopic symptoms in infancy (1992)

A total of 105 "high-risk" infants born in 1988 were studied prospectively from birth to 18 months of age. The infants were recommended breastfeeding and/or hypoallergenic formula (Nutramigen or Profylac) combined with avoidance of solid foods during the first 6 months of life. All mothers had unrestricted diet. Avoidance of daily exposure to tobacco smoke, furred pets and dust-collecting materials in the bedroom were advised. This prevention group was compared with a control group consisting of 54 identically defined "high-risk" infants born in 1985 in the same area. All infants had either severe single atopic predisposition combined with cord blood IgE > or = 0.5 KU/l or biparental atopic predisposition. The control group had unrestricted diet and was not advised about environmental factors. Apart from the prevention programme and year of birth the prevention group and the control group were comparable. The parents were highly motivated and compliance was good. The rate of participation was 97%, and 85% followed the dietary measures strictly. The cumulative prevalence of atopic symptoms was significantly lower at 18 months in the prevention group (32%), as compared with the control group (74%) (p < 0.01), due to reduced prevalence of recurrent wheezing (13% versus 37%; p < 0.01), atopic dermatitis (14% versus 31%; p < 0.01), vomiting/diarrhoea (5% versus 20%; p < 0.01) and infantile colic (9% versus 24%; p < 0.01). The cumulative prevalence of food allergy was significantly lower in the prevention group (6% versus 17%; p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Objective measures of speech quality (subjective) (1985)

This thesis investigates objective measures of speech quality, or measures which can be computed from properties of an original and a distorted speech waveform. Two sets of objective measures are investigated. The first set is designed to estimate the specific types of perceived distortions specified by the 'parametric' subjective quality scales of the Diagnostic Acceptability Measure (DAM), a subjective speech quality test. The narrow scope of these parametric scales promotes a close coupling between physical quantities and their associated perceptual qualities, resulting in quite accurate measures. The second set of objective measures estimate the composite acceptability scale of the DAM, a scale measuring overall speech acceptability. The first set of measures are used as a foundation for designing the second set of measures.
The speech quality data base used in this research is quite extensive. It consists of a total of 1056 examples of distorted speech produced by various speech coder and other speech distorting systems and their associated subjective quality ratings as produced by the Diagnostic Acceptability Measure.
The thesis research can be divided into three parts. In the first part, the relationship between the scales of the Diagnostic Acceptability Measure and several of the best available objective speech quality measures is analyzed. It is demonstrated, using Multidimensional Scaling, that current objective measures produce poor estimates of composite acceptability because they incorporate little of the information provided by the parametric subjective measures. Multiple linear regression is used to find a linear relationship between the parametric subjective quality scales and the composite acceptability scale. The resulting regression model produces very good estimates of composite acceptability using only a subset of the parametric qualities. Because of this relationship, objective measures of parametric quality can be used as the basis for a measure of composite acceptability.
In the second part, a set of objective measures is designed which provide dramatically improved estimates of the parametric qualities of the Diagnostic Acceptability Measure. Performance is measured in terms of the correlation between actual and estimated subjective quality. Multidimensional scaling graphically shows the remarkable ability of these measures to estimate the parametric subjective qualities.
And finally, in the third part, the parametric objective measures are combined into a single composite measure for estimating subjective composite acceptability. Several measures are presented, with correlations to composite acceptability ranging from 0.81 to 0.85.
Optimized RF shielding techniques for simultaneous PET/MR (2011)

For a given required shielding factor at the proton resonant frequency, the eddy currents induced by the MR gradient fields may be reduced by employing a multiple shell setup.
ChemInform Abstract: Chemistry on the Damage and Repair of Thymine and Thymidine Derivatives (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly (2013)

In vitro recombination methods have enabled one-step construction of large DNA sequences from multiple parts. Although synthetic biological circuits can in principle be assembled in the same fashion, they typically contain repeated sequence elements such as standard promoters and terminators that interfere with homologous recombination. Here we use a computational approach to design synthetic, biologically inactive unique nucleotide sequences (UNSes) that facilitate accurate ordered assembly. Importantly, our designed UNSes make it possible to assemble parts with repeated terminator and insulator sequences, and thereby create insulated functional genetic circuits in bacteria and mammalian cells. Using UNS-guided assembly to construct repeating promoter-gene-terminator parts, we systematically varied gene expression to optimize production of a deoxychromoviridans biosynthetic pathway in Escherichia coli. We then used this system to construct complex eukaryotic AND-logic gates for genomic integration into embryonic stem cells. Construction was performed by using a standardized series of UNS-bearing BioBrick-compatible vectors, which enable modular assembly and facilitate reuse of individual parts. UNS-guided isothermal assembly is broadly applicable to the construction and optimization of genetic circuits and particularly those requiring tight insulation, such as complex biosynthetic pathways, sensors, counters and logic gates.
Multimodal nonlinear microscopy of head and neck carcinoma — toward surgery assisting frozen section analysis (2016)

Nonlinear multimodal imaging is verified objectively as a valuable diagnostic tool that complements conventional staining protocols and can serve as filter in future clinical routine reducing the pathologist's workload. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1552, 2016.