gebhart/patrepeval huggingface dataset:
The parathyroid hormones: bone-forming agents for treatment of osteoporosis. (2000)

This is a 3-part article. Part 1 is an overview of bone formation and resorption and the consequences of estrogen loss on bone. Part 2 comprehensively reviews the most current data on the ability of a family of potent osteoblast-stimulating bone-builders, the native 84-amino-acid parathyroid hormone (PTH), and certain of its 31- to 38- amino-acid fragments to stimulate the growth of animal and human bones. These PTHs are currently in, or about to enter, clinical trial as treatment for postmenopausal osteoporosis. Part 3 provides a detailed consideration of how these PTHs might stimulate bone growth via PTH receptor signaling.
Development of the Ball Rust Test-A Laboratory Test Replacing the Sequence IID Engine Test (1997)

<div class="htmlview paragraph">A laboratory Ball Rust Test (BRT) has been jointly developed by General Motors and Ethyl Corporation to replace the current Sequence IID engine test, and standard test procedures have been established to assess the rust/corrosion protection ability of experimental and commercial oils. Under the optimum test conditions developed, BRT data on eight industry reference and eighteen industry supplied oils showed a reasonable correlation with Sequence IID average rust test results.</div> <div class="htmlview paragraph">The capability of the BRT for differentiating oil quality was further demonstrated by evaluating 132 commercial oils obtained from around the world: oils with insufficient protection, such as those with API performance ratings of SA to SE, performed poorly in the BRT; oils with API ratings of SF, SG, and SH performed well in the test. The BRT will be made available to ASTM for development of a precision statement and for inclusion in future engine oil performance specifications.</div>
A magnetorheological actuation system: test and model (2008)

Self-contained actuation systems, based on frequency rectification of the high frequency motion of an active material, can produce high force and stroke output. Magnetorheological (MR) fluids are active fluids whose rheological properties can be altered by the application of a magnetic field. By using MR fluids as the energy transmission medium in such hybrid devices, a valving system with no moving parts can be implemented and used to control the motion of an output cylinder shaft. The MR fluid based valves are configured in the form of an H-bridge to produce bi-directional motion in an output cylinder by alternately applying magnetic fields in the two opposite arms of the bridge. The rheological properties of the MR fluid are modeled using both Bingham plastic and bi-viscous models. In this study, the primary actuation is performed using a compact terfenol-D rod driven pump and frequency rectification of the rod motion is done using passive reed valves. The pump and reed valve configuration along with MR fluidic valves form a compact hydraulic actuation system. Actuator design, analysis and experimental results are presented in this paper. A time domain model of the actuator is developed and validated using experimental data.
The effect of protein and urine on uropathogen adhesion to polymer substrata (1990)

Uropathogenic adhesion was measured using a range of polymer materials with differing surface tension properties. Experiments were carried out in the presence of phosphate buffered saline (controls), Tamm Horsfall protein (THP), and human urine with quantitation by image analysis. The results showed that THP did not bind to the polymer materials and therefore did not act as a receptor surface for type 1 fimbriated Escherichia coli. However, the THP did interfere with adhesion by binding directly to these organisms as well as to Pseudomonas aeruginosa, Staphylococcus epidermidis, and, to a lesser extent, Proteus mirabilis. Incubation of the uropathogens in THP and urine resulted in altered adhesion profiles to polymer surfaces, with no single trend apparent. The results emphasize that fluid components, particularly proteins, and substratum surface tension influence bacterial adhesion to biomaterials.
Intraretinal Oxygen Distribution in the Monkey Retina and the Response to Systemic Hyperoxia (2005)

In the outer retina of the monkey the P(O2) minimum is lower, and the oxygen consumption rate is higher in the parafoveal region. During systemic hyperoxia, outer retinal oxygen consumption is unaffected, but in the foveal area, total oxygen consumption increases. This regulation of oxygen consumption in the monkey retina is comparable to that reported in lower mammals and may represent an important mechanism in retinal homeostasis.
Epidemiology of Brain Injury (2006)

Abstract Injury has been the fourth leading cause of mortality in the United States for the past 50 years and is the foremost cause of death among persons aged 1–44.12 In 2001, 157,078 persons died of acute traumatic injury in the United States—a rate of 55 per 100,000 persons per year. This number is only 6460 fewer than the total number of persons who died from stroke in the same year.59 Injury is the most rapidly increasing cause of death in developing countries, resulting from the combination of increased urbanization and motor vehicle use, along with reductions in deaths due to infectious diseases.23 From the mid-1950s to the mid-1960s, for example, injury fatalities increased 600% in Mexico, 450% in Thailand, 243% in Venezuela, and 200% in Chile.89 Proportional mortality rates from injury in Latin America, Asia, Africa, and Oceania range as high as 10%.4,6,9,19,46,60,64,89 For most developing countries, the mortality rate from injury is substantially greater than the rate in the United States.
Interference Cancellation Based on Adaptive Signal Processing for MIMO RF Repeaters (2010)

In this paper, we propose adaptive algorithms for interference cancellation in RF repeaters with multiple transmit and receive antennas. When multiple antennas are used in a repeater, the imperfect isolation between transmit and receive antennas causes the feedback interference which is modeled as multi-input multi-output (MIMO) channel. To remove the feedback interference, we derive the least mean square (LMS) algorithm and the recursive least squares (RLS) algorithm for interference cancellation based on adaptive signal processing techniques. Through computer simulations for the proposed algorithms, we analyze the convergence characteristics and compare the steady-state performance for interference cancellation.
Evolutionary dynamics of bacteria in the gut microbiome within and across hosts (2017)

Abstract Gut microbiota are shaped by a combination of ecological and evolutionary forces. While the ecological dynamics have been extensively studied, much less is known about how species of gut bacteria evolve over time. Here we introduce a model-based framework for quantifying evolutionary dynamics within and across hosts using a panel of metagenomic samples. We use this approach to study evolution in ∼30 prevalent species in the human gut. Although the patterns of between-host diversity are consistent with quasi-sexual evolution and purifying selection on long timescales, we identify new genealogical signatures that challenge standard population genetic models of these processes. Within hosts, we find that genetic differences that accumulate over ∼6 month timescales are only rarely attributable to replacement by distantly related strains. Instead, the resident strains more commonly acquire a smaller number of putative evolutionary changes, in which nucleotide variants or gene gains or losses rapidly sweep to high frequency. By comparing these mutations with the typical between-host differences, we find evidence that some sweeps are seeded by recombination, in addition to new mutations. However, comparisons of adult twins suggest that replacement eventually overwhelms evolution over multi-decade timescales, hinting at fundamental limits to the extent of local adaptation. Together, our results suggest that gut bacteria can evolve on human-relevant timescales, and they highlight the connections between these short-term evolutionary dynamics and longer-term evolution across hosts.
Importance of input data normalization for the application of neural networks to complex industrial problems (1997)

Recent advances in artificial intelligence have allowed the application of such technologies in real industrial problems. We have studied the application of backpropagation neural networks to several problems of estimation and identification in nuclear power plants. These problems often have been reported to be very time-consuming in the training phase. Among the different approaches suggested to ease the backpropagation training process, input data pretreatment has been pointed out, although no specific procedure has been proposed. We have found that input data normalization with certain criteria, prior to a training process, is crucial to obtain good results as well as to fasten significantly the calculations. This paper shows how data normalization affects the performance error of parameter estimators trained to predict the value of several variables of a PWR nuclear power plant. The criteria needed to accomplish such data normalization are also described.
Serum soluble IL-2 receptor as a marker of lymphocyte activation in some autoimmune diseases. Effect of immunosuppressive therapy. (2002)

Our experience regarding serum soluble interleukin-2 receptor (sIL-2R) measurement as a marker of lymphocyte activation consists of patients with autoimmune disease: 37 with systemic lupus erythematosus (SLE), 23 with autoimmune hepatitis (AIH), 74 with inflammatory bowel disease and six with Wegener's granulomatosis (WG). The influence of immunosuppressive therapy has also been assessed. Serum sIL-2R in SLE is significantly higher than in healthy controls and good correlation is found between sIL-2R and disease activity. Severity of kidney inflammation in lupus nephritis can be reflected by the increased excretion of sIL-2R. It was found that sIL-2R level significantly falls when the disease becomes clinically inactive after immunosuppressive therapy, but in many cases (up to 50%) it does not reach normal levels. The last finding suggests that lymphocyte activation may still be present even though the disease is considered inactive under clinical criteria and support the need of prolonged immunosuppression after the first signs of remission. In AIH the serum levels of sIL-2R are elevated in all patients with active disease; all cases with "highly active" disease have significantly higher concentrations than patients with "mild activity". A good correlation has been demonstrated between elevated serum sIL-2R values and anti-asialoglycoprotein receptor (ASGPR) titer (the specific marker of AIH). The follow-up study showed a significant decrease of both sIL-2R levels and anti-ASGPR titer after 3-9 month immunosuppressive therapy. The findings support that sIL-2R and anti-ASGPR titer could serve as reliable humoral markers for disease-specific activity. Compared with inactive ulcerative colitis (UC) and Crohn's disease (CD), significantly higher levels of sIL-2R were present in the serum of patients with active disease, and in inactive disease than in healthy age-matched controls. Methotrexate (MTX) therapy of patients with refractory UC resulted in sIL-2R decrease at the end of therapeutic period (20 i.m. injections of once a week 25 mg), good responders showing > 50% decrease even at 5-7 weeks of treatment. Serum sIL-2R is elevated in all six patients with WG. Contrary to anti-neutrophil cytoplasmic antibodies (ANCA), sIL-2R remains elevated above cut-off for normal range, despite clinical improvement following immunosuppressive treatment. The last observation suggests that serum sIL-2R is not a good measure of the disease activity and argue for the need of longer immunosuppressive therapy just after the first days of clinical remission.
Mad3p, a pseudosubstrate inhibitor of APC <sup>Cdc20</sup> in the spindle assembly checkpoint (2007)

Inappropriate attachment/tension between chromosomal kinetochores and the kinetochore microtubules activates the spindle assembly checkpoint, which delays anaphase by blocking the ubiquitin-mediated degradation of securin/Pds1p by APCCdc20. The checkpoint proteins Mad2 and Mad3/BubR1 bind to Cdc20, although how they inhibit APCCdc20 is unclear. We investigated the roles of two evolutionarily conserved KEN boxes and a D box within Mad3/BubR1. Although such motifs usually mediate APC-substrate recognition and ubiquitination, they have no apparent role in Mad3p turnover in Saccharomyces cerevisiae. Instead, these motifs are important for Mad3p function in the checkpoint and for binding to Cdc20p. We show that the Mad3p D box and KEN boxes function together to mediate Cdc20p-Mad3p interaction and that Mad3p and an anaphase-promoting complex (APC) substrate, Hsl1p, compete for Cdc20p binding in a D-box- and KEN-box-dependent manner. In vivo, we observed an increased binding of Cdc20p to Mad3p and decreased binding to Hsl1p upon checkpoint activation. Furthermore, we demonstrate that Mad2p stimulates the association between Mad3p and Cdc20p and that this stimulated binding requires KEN box 1 within Mad3p. These findings implicate Mad3p as a pseudosubstrate inhibitor of APCCdc20, competing with APC substrates for Cdc20p binding. We present a model aimed at unifying previous analyses of checkpoint function by focusing on the Mad3-Cdc20 interaction.
Not only the nature of peptide but also the characteristics of cell membrane determine the antimicrobial mechanism of a peptide (1999)

The mechanisms of antimicrobial actions of magainin 2, buforin II and poly L-lysine against various Escherichia coli strains were studied. Poly L-lysine inhibited BL21, AD 434 and GroE+/DnaK+ growth without lysing the cell. Magainin 2 had a pore-forming activity on BL 21 and AD 434 membrane but could not inhibit the GroE+/DnaK+ growth in a nutrient-rich medium. Buforin II, which killed BL21 and AD 434 without cell membrane damage, lysed GroE+/DnaK+ to death. Once they were introduced into the cell by electroporation, all three peptides were able to inhibit cell growth at concentrations of 10 times lower than their MICs. These results indicate that the nature of the peptide and also the characteristics of the cell membrane determine the antimicrobial actions of a peptide.
CD40‐mediated lymphotoxin α expression in human B cells is tyrosine kinase dependent (1995)

The cytokine lymphotoxin (LT)alpha is known to play a role in B cell activation. As the engagement of the B cell antigen CD40 is known to lead to B cell proliferation and differentiation, we studied LT alpha expression in human B cells after CD40 ligation. We demonstrate that anti-CD40 monoclonal antibody (mAb) induces strong LT alpha mRNA and surface-expression in human tonsil B cells. Induction of LT alpha mRNA and surface expression by CD40 ligation is inhibited by the protein tyrosine kinase (PTK) inhibitors herbimycin and genistein in a dose-dependent manner. The protein kinase C (PKC)-specific inhibitors sphingosine and bis-indolylmaleimide caused negligible inhibition of anti-CD40-induced LT alpha mRNA and surface expression. No inhibition is observed with the protein kinase (PKA) inhibitors H89 and HA1004. Cross-linking of the transmembrane phosphatase CD45 to CD40 by using goat-anti-mouse F(ab')2 fragments strongly inhibits CD40-mediated LT alpha expression in human B cells, confirming the role of PTK activation in CD40-mediated induction of LT alpha expression. Inhibitors of the serine/threonine protein phosphatases PP1 and PP2A, okadaic acid and calyculin induce LT alpha mRNA expression. In contrast, cyclosporin A, an inhibitor of the serine/threonine phosphatase calcineurin has no effect on anti-CD40-induced LT alpha expression. These results suggest that induction of LT alpha expression in B cells following engagement of CD40 involves activation of protein tyrosine kinases.
Some good practices for applying convolutional neural networks to buried threat detection in Ground Penetrating Radar (2017)

Ground Penetrating Radar (GPR) is a remote sensing modality that has been researched extensively for buried threat detection. For this purpose, algorithms can be developed to automatically determine the presence of such threats. To train such algorithms, small 2-dimensional images can be extracted from the larger image, or volume, of GPR data. One thread of research in the buried threat detection literature is to use visual descriptors from the computer vision literature. One recent, very successful approach in that field is the use of deep convolutional neural networks (CNNs). Applying CNNs requires a large number of design choices which complicate their use. In this work, we investigate their application to GPR data and adapt several recent advances from the CNN literature to improve detection performance on GPR data. In particular, we investigate the initialization step of pretraining and propose a dataset augmentation protocol. The efficacy of these approaches are evaluated on several architectures with a relatively similar number of network parameters to learn. The results indicate that both pretraining and dataset augmentation help achieve higher detection performance.
Investigation of interface intermixing and roughening in low-temperature-grown AlAs/GaAs multiple quantum wells during thermal annealing by chemical lattice imaging and x-ray diffraction (1995)

The effect of thermal annealing on the interface quality in undoped, AlAs/GaAs multiple quantum well (MQW) structures grown at a low substrate temperature (310 °C) by molecular beam epitaxy has been investigated using chemical lattice imaging and high resolution x-ray diffraction. The low-temperature-grown MQW is of high crystalline quality comparable to the standard-temperature-grown MQW. However, significant interface roughening and intermixing occurs at the quantum well heterointerface when the structures are annealed beyond 700 °C. The effective activation energy for interdiffusion is estimated as 0.24±0.07 eV. The structural properties observed here suggest that the excess arsenic associated with the low-temperature growth substantially enhances the diffusion of column III vacancies across an interface, which leads directly to intermixing of Al and Ga.
Learning the click-through rate for rare/new ads from similar ads (2010)

Ads on the search engine (SE) are generally ranked based on their Click-through rates (CTR). Hence, accurately predicting the CTR of an ad is of paramount importance for maximizing the SE's revenue. We present a model that inherits the click information of rare/new ads from other semantically related ads. The semantic features are derived from the query ad click-through graphs and advertisers account information. We show that the model learned using these features give a very good prediction for the CTR values.
Dhalion in action (2018)

In a world where organizations are being inundated with data from various sources, analyzing data and gaining actionable insights in real-time has become a key service differentiator. Over the last few years, several stream processing frameworks have been developed to address the need for large-scale, real-time analytics. A crucial challenge in these environments is the complexity of configuring, managing and deploying long-running streaming applications. Operators must carefully tune these systems to balance competing objectives such as resource utilization and performance. At the same time, they must also account for external shocks such as unexpected load variations and service degradations. In this demonstration, we show how operators can maintain healthy streaming applications without manual intervention while still meeting their performance objectives. We use Dhalion, an open-source library that sits on top of the streaming application, observes its behavior and automatically takes actions to keep the application in a healthy state. In particular, through various Dhalion policies that are configured by the attendees, we demonstrate how a streaming application can meet its performance objective by automatically configuring the amount of resources needed at the various application stages. We also demonstrate Dhalion's modularity and extensibility that greatly simplifies the process of developing new policies which address different application requirements.
Epitope Extraction Technique Using a Proteolytic Magnetic Reactor Combined with Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry as a Tool for the Screening of Potential Vaccine Lead Peptides (2005)

Epitope extraction technique is based on the specific digestion of a target protein followed by immunoaffinity isolation of a specific recognition peptide. This technique, in combination with mass spectrometry, has been efficiently used for epitope identification. The major goal of this work was to utilize newly developed enzyme and immunoaffinity magnetic reactors for the epitope extraction procedure and confirm the efficiency of this improved system for epitope screening of proteins. Alginic acid-coated magnetite microparticles with immobilized TPCK-trypsin provided high working efficiency with low non-specific adsorption, digestion time in minutes and low frequency of missed cleavages. The sensitivity and specificity of tryptic fragmentation of the beta-amyloid-peptide Abeta (1-40) as a model polypeptide was confirmed by Fourier-transform ion cyclotron resonance mass spectrometry analysis. The Sepharose reactor or immunoaffinity magnetic reactors, both with anti-amyloid-beta monoclonal antibodies, were used for specific isolation and identification of target peptides. In this way, the epitope extraction technique combined with mass spectrometric analysis is shown to be an excellent base for molecular screening of potential vaccine lead proteins.
Astaxanthin deposition in the flesh of Atlantic Salmon, Salmo salar L., in relation to dietary astaxanthin concentration and feeding period (1995)

Atlantic salmon, Salmo salar L., were fed nine experimental diets containing from 0 to 200 mg astaxanthin per kg−1 for six time periods, ranging from 3 to 21 months, in sea cages at Matre Aquaculture Research Station, Matredal, Norway. The sampled fish had an initial mean weight of 115 g and reached a weight of 3.2 kg at the termination of the experiment. Every third month, 10 fish from each dose and time group were sampled and the astaxanthin concentration in the flesh determined. The amount of astaxanthin in the flesh ranged from 0.7 to 8.9 mg kg−1 at the termination of the experiment. This paper discusses deposition of astaxanthin in the flesh of Atlantic salmon in relation to dietary carotenoid levels in the 0–200 mg kg−1 range and feeding times of 3–21 months. Under the conditions of this experiment, no significant effect on astaxanthin deposition rate could be achieved by increasing the astaxanthin level above 60 mg kg dry feed−1. Atlantic salmon should be fed astaxanthin-supplemented diets during the whole seawater stage in order to obtain maximal astaxanthin level in the flesh.
Public sector restructuring: the human dimensions (1996)

Points to the restructuring which is continually happening in government departments and agencies, and looks at what outplacement services have to offer: redundancy counselling, group seminars, workshops, career planning, job skills/experience analysis, job search facilities, negotiation with trade unions, general advice on a wide range of issues, and preparation for the transition into private sector employment. Drawing on the author’s own experiences at the FOCUS Consultancy, cites case examples, showing the wide variety of outplacement programmes tailored to individual or company needs. Highlights the benefits to management in maintaining morale and management credibility.