gebhart/patrepeval huggingface dataset:
Opiates inhibit adenylate cyclase by stimulating GTP hydrolysis. (1981)

Specific, GTP hydrolysis catalyzed by membranes prepared from neuroblastoma--glioma (NG108-15) hybrid cells can be measured in the presence of adenosine-5'-[beta, gamma-imido] triphosphate (p[NH]ppA), ATP, and a nucleotide triphosphate-regenerating system. Opiates and opioid peptides stimulate low Km GTP hydrolysis when measured in the presence of Na+ and Mg2+. Opiate stimulation is rapid, stereospecific, and reserved by the antagonist naloxone. Potencies of opiates as stimulators of GTP hydrolysis and as inhibitors of adenylate cyclase are closely correlated. Agents that stimulate adenylate cyclase, including prostaglandin E1, 2-Cl-adenosine, secretin, and NaF, have little or no effect upon the rate of GTP hydrolysis. Opiates have no effect upon either adenylate cyclase or GTPase activity in membranes prepared from C6-BU1 glioma cells, which lack opiate receptors. In view of the pivotal role of GTP in the activation of adenylate cyclase, we conclude that receptor-mediated stimulation of GTP hydrolysis is the mechanism by which opiates and other inhibitory hormones lower adenylate cyclase activity in NG108-15 cell membranes.
Convolutional Neural Networks for joint object detection and pose estimation: A comparative study (2014)

In this paper we study the application of convolutional neural networks for jointly detecting objects depicted in still images and estimating their 3D pose. We identify different feature representations of oriented objects, and energies that lead a network to learn this representations. The choice of the representation is crucial since the pose of an object has a natural, continuous structure while its category is a discrete variable. We evaluate the different approaches on the joint object detection and pose estimation task of the Pascal3D+ benchmark using Average Viewpoint Precision. We show that a classification approach on discretized viewpoints achieves state-of-the-art performance for joint object detection and pose estimation, and significantly outperforms existing baselines on this benchmark.
Cation-π Interactions in Lipocalins: Structural and Functional Implications (2012)

The cation-π interaction impacts protein folding, structural stability, specificity, and molecular recognition. Cation-π interactions have been overlooked in the lipocalin family. To fill this gap, these interactions were analyzed in the 113 crystal and solution structures from the lipocalin family. The cation-π interactions link previously identified structurally conserved regions and reveal new motifs, which are beyond the reach of a sequence alignment algorithm. Functional and structural significance of the interactions were tested experimentally in human tear lipocalin (TL). TL, a prominent and promiscuous lipocalin, has a key role in lipid binding at the ocular surface. Ligand binding modulation through the loop AB at the "open" end of the barrel has been erroneously attributed solely to electrostatic interactions. Data revealed that the interloop cation-π interaction in the pair Phe28-Lys108 contributes significantly to stabilize the holo-conformation of the loop AB. Numerous energetically significant and conserved cation-π interactions were uncovered in TL and throughout the lipocalin family. Cation-π interactions, such as the highly conserved Trp17-Arg118 pair in TL, were educed in low temperature experiments of mutants with Trp to Tyr substitutions.
THE EFFECTS OF HYDEASTIS AND ITS ALKALOIDS ON BLOOD PRESSURE. (1908)

Hydrastis is usually considered as having marked styptic properties due to a local vasoconstriction, and it has been recommended as a remedy of great value in uterine hemorrhages<sup>1</sup>and hemoptysis.<sup>2</sup>This is based mainly on clinical observations. Looking for experimental evidence to support this view, it was interesting to note that practically all the investigators found no constriction of the arterioles. They obtained, on intravenous injection of the drug, a marked fall of blood pressure, followed by a slight rise, the latter being attributed to stimulation of the vasomotor center (Marfori,<sup>3</sup>Falck,<sup>4</sup>Pellacani,<sup>5</sup>Fellner,<sup>6</sup>Cushny<sup>7</sup>). With this contradiction of the clinical observations by the experimental evidence of numerous workers in mind, the present investigation of the effects of hydrastis on the mammalian circulation was undertaken. Investigation was also made of the effects of its two principal alkaloids, hydrastin and berberin, and of the
Edge overgrowth of spiral bimetallic hydroxides ultrathin-nanosheets for water oxidation (2015)

The structure of edges may dramatically influence the properties of nanomaterials, so the rational design or control over the structures of the edges is required. Here we synthesized spiral ultrathin-nanosheets with overgrown edges (SUNOE) of NiFe, CoNi and CoFe bimetallic hydroxides by governing the growth rates of different directions in screw dislocation driven growth (SDDG) in nonaqueous solvents. The driving force for the SDDG is supersaturation, which could be controlled by the concentration of the different precursors, thus achieving non-uniform structures of the edges and inner sheets. NiFe, CoNi and CoFe bimetallic hydroxides possess layered structures, in which overgrown edges may prevent them from re-stacking. The as prepared SUNOE all show good performance for the oxygen evolution reaction (OER) in the electrolysis of water, and the lowest onset potential was 1.45 V (<i>vs.</i> RHE) (the lowest potential when the current density reached 10 mA cm<sup>-2</sup> was 1.51 V (<i>vs.</i> RHE)).
Enzyme deficiency in cholesteryl ester storage disease (1972)

Cholesteryl ester storage disease has been shown to involve severe deficiency of acid cholesteryl ester hydrolase and triglyceride lipase activity in liver, spleen, and lymph node. The cholesteryl ester hydrolase was also deficient in aorta. Tissue storage of both cholesteryl esters and triglycerides is generalized. Both the lipid and enzymatic changes are very similar to those in Wolman's disease.
Early events leading to erythroid differentiation in mouse Friend cells revealed by cell fusion experiments. (1984)

Cell fusion with two genetically marked Friend (murine erythroleukemia) cells has made it possible to characterize the very early events leading to erythroid differentiation, particularly the nature of reactions initiated by inducers such as dimethyl sulfoxide. We have found that brief exposure of Friend cells to dimethyl sulfoxide (as well as butyric acid or hexamethylene-bisacetamide) induces an early cellular activity required for erythroid differentiation which is detected only by fusion with ultraviolet-irradiated cells. The induction process of this activity consists of at least two distinct stages. In the first stage, the reaction proceeds without supply of metabolites from the medium and exhibits sensitivity to tumor promoters. The second stage is tightly coupled to cellular metabolic activity, notably protein synthesis. Under normal conditions, the induced activity is short-lived, suggesting turnover of the molecules responsible for this activity. There appears to be a signal produced following dimethyl sulfoxide pulse which acts as an inducer for this activity. The signal remains active for as long as 40 hr when protein synthesis is blocked.
Poly(alkylene itaconate)s – an interesting class of polyesters with periodically located exo-chain double bonds susceptible to Michael addition (2015)

Dibutyl itaconate, a bio-sourced monomer, is melt-condensed with various aliphatic diols to generate unsaturated polyesters carrying <italic>exo</italic>-chain double bonds; these <italic>exo</italic>-chain double bonds readily undergo Micheal addition with a variety of organic thiols and amines, including some derviatized amino acids, like cysteine and proline.
Effects of piceatannol derivatives in the antiproliferative activity of the anticancer-drug doxorubicine and on apoptosis induction in MDR cancer cell lines (2006)

Historically, plants have provided a source of novel drug compounds and have shown great promise in the treatment of diseases, particularly cancers. A great number of phytochemicals have been demonstrated to have antitumor activity in various experimental systems. Their mechanism of action may affect many different targets of the signal transduction pathway that modulate gene expression, cell cycle progression, proliferation, cell mortality, metabolism and apoptosis [1].
Beta transforming growth factors are potential regulators of B lymphopoiesis. (1987)

Members of the transforming growth factor beta (TGF-beta) family of polypeptides were found to be potent in vitro inhibitors of kappa light chain expression on normal bone marrow-derived and transformed cloned pre-B cells, and of the maturation of these cells to mitogen responsiveness. The inhibition by TGF-beta was selective in that Ia expression was not blocked. Together with the observations that LPS, IL-1, NZB serum factors, IL-4, and IFN-gamma preferentially induced either kappa or Ia, or both, on a pre-B cell line, these results further suggest that acquisition of Ig and class II molecules is independently controlled by different antagonists as well as agonists. In addition, kappa chain induction by IFN-gamma does not appear to be as sensitive to TGF-beta downregulation as that stimulated by other factors tested, and this raises the possibility that activation of the same gene may result from different transmembrane signaling pathways. In contrast to the inhibitory effects of TGF-beta on kappa acquisition by pre-B cells and on kappa increase after exposure of mature B cells to LPS, as measured by kappa RNA levels and/or surface fluorescence, no inhibition was observed on unstimulated spleen B cells or on two cloned B cell lines that constitutively produce kappa. Thus, TGF-beta may function during specific stages of B cell differentiation by inhibiting initiation of, or increased transcription of Ig genes, and therefore, may be an important negative regulator of B lymphopoiesis. It is the first natural substance found to have this effect.
Bachem – Insights into Peptide Chemistry Achievements by the World's Leading Independent Manufacturer of Peptides (2013)

The Swiss fine chemicals company Bachem, pioneer and specialist in the chemical synthesis of peptides, has also become an internationally leading manufacturer of peptide active pharmaceutical ingredients (APIs). In response to increasing demands in scale and purity, Bachem's research efforts centered on the chemistry involved in solid-phase peptide synthesis and the production of the required amino acid derivatives with the aim of a continuous improvement of the technology. The resulting optimized protocols together with high-throughput equipment enabled us to manufacture long peptide APIs and, more recently, even pharma-grade glycoproteins in industrial scale.
On-demand time synchronization with predictable accuracy (2011)

Time synchronization remains as a challenging task in wireless sensor networks that face severe resource constraints. Unlike previous work's aiming at pure clock accuracy, this paper proposes On-Demand Synchronization (ODS), a design to achieve efficient clock synchronization with customized performance. By carefully modeling the error uncertainty of skew detection and its propagation over time, ODS develops a novel uncertainty-driven mechanism to adaptively adjust each clock calibration interval individually rather than traditional periodic synchronization, for minimum communication overhead while satisfying the desired accuracy. Besides, ODS provides a nice feature of predictable accuracy, allowing nodes to acquire the useful information about real-time qualities of their synchronization. We implemented ODS on the MICAz mote platform, and evaluated it through test-bed experiments with 33 nodes as well as simulations obeying real world conditions. Results show that ODS is practical, flexible, and quickly adapts to varying accuracy requirements and different traffic load in the network for improved system efficiency.
R2 and R2/R1 hybrid non-autonomous retrotransposons derived by internal deletions of full-length elements (2012)

The R2 SIDE and R2/R1 hybrid SIDEs are rare examples of non-autonomous retrotransposons in the Drosophila genome. Associated non-autonomous elements and in vivo template jumps are two additional characteristics R2 shares with other non-LTR retrotransposons such as mammalian L1s. Analysis of the hybrid SIDEs provides supporting evidence that R1 elements, like R2 elements, recognize their 3' untranslated region (UTR) sequences and, thus, belong to the stringent class of non-LTR elements.
HIPAA Is Here (2003)

CLARK, ANGELA P. PhD, RN, CS, FAAN; GERHARDT, SUSAN D. MSN, RN, CCRN Author Information
Organic Combustion Apparatus for Highly Volatile and for Inflammable Liquids (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic Combustion Apparatus for Highly Volatile and for Inflammable LiquidsJohannes H. Bruun and W. B. Mason FaulconerCite this: Ind. Eng. Chem. Anal. Ed. 1936, 8, 4, 315–316Publication Date (Print):July 1, 1936Publication History Published online1 May 2002Published inissue 1 July 1936https://pubs.acs.org/doi/10.1021/ac50102a043https://doi.org/10.1021/ac50102a043research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Endoglin-Mediated Suppression of Prostate Cancer Invasion Is Regulated by Activin and Bone Morphogenetic Protein Type II Receptors (2013)

Mortality from prostate cancer (PCa) is due to the formation of metastatic disease. Understanding how that process is regulated is therefore critical. We previously demonstrated that endoglin, a type III transforming growth factor β (TGFβ) superfamily receptor, suppresses human PCa cell invasion and metastasis. Endoglin-mediated suppression of invasion was also shown by us to be dependent upon the type I TGFβ receptor, activin receptor-like kinase 2 (ALK2), and the downstream effector, Smad1. In this study we demonstrate for the first time that two type II TGFβ receptors are required for endoglin-mediated suppression of invasion: activin A receptor type IIA (ActRIIA) and bone morphogenetic protein receptor type II (BMPRII). Downstream signaling through these receptors is predominantly mediated by Smad1. ActRIIA stimulates Smad1 activation in a kinase-dependent manner, and this is required for suppression of invasion. In contrast BMPRII regulates Smad1 in a biphasic manner, promoting Smad1 signaling through its kinase domain but suppressing it through its cytoplasmic tail. BMPRII's Smad1-regulatory effects are dependent upon its expression level. Further, its ability to suppress invasion is independent of either kinase function or tail domain. We demonstrate that ActRIIA and BMPRII physically interact, and that each also interacts with endoglin. The current findings demonstrate that both BMPRII and ActRIIA are necessary for endoglin-mediated suppression of human PCa cell invasion, that they have differential effects on Smad1 signaling, that they make separate contributions to regulation of invasion, and that they functionally and physically interact.
Architecture of a federated query engine for heterogeneous resources. (2009)

The Federated Utah Research and Translational Health e-Repository (FURTHeR) is a Utah statewide informatics platform for the new Center for Clinical and Translational Science at the University of Utah. We have been working on one of FURTHeR's key components, a federated query engine for heterogeneous resources, that we believe has the potential to meet some of the fundamental needs of translational science to access and integrate diverse biomedical data and promote discovery of new knowledge. The architecture of the federated query engine for heterogeneous resources is described and demonstrated.
Asymmetric Synthesis X: The High Enantioselective Synthesis of (R)-α-Substituted Benzylic Amines Via the Modified (+)-Camphor Derivative as Chiral Synthon (1990)

Abstract A new chiral synthon-10-substituted (+)-camphor derivative (III) is synthesized. The alkylation of the (III) with a variety of alkylating agents gives the high enantioselectivity ranging from 72–100%e. e. And the crystal structures of the (III) and (IV) are involved in explaining the results.
Stream-Oriented Network Traffic Capture and Analysis for High-Speed Networks (2014)

Intrusion detection, traffic classification, and other network monitoring applications need to analyze the captured traffic beyond the network layer to allow for connection-oriented analysis, and achieve resilience to evasion attempts based on TCP segmentation. Existing network traffic capture frameworks, however, provide applications with raw packets and leave complex operations like flow tracking and TCP stream reassembly to application developers. This gap, between what applications need and what systems provide, leads to increased application complexity, longer development time, and most importantly, reduced performance due to excessive data copies between the packet capture subsystem and the stream processing module. This paper presents the Stream capture library (Scap), a network monitoring framework built from the ground up for stream-oriented traffic processing. Based on a kernel module that directly handles flow tracking and TCP stream reassembly, Scap delivers to user-level applications flow-level statistics and reassembled streams by minimizing data movement operations and discarding uninteresting traffic at early stages, while it inherently supports parallel processing on multi-core architectures, and uses advanced capabilities of modern network cards. Our experimental evaluation shows that Scap can capture all streams for traffic rates two times higher than other stream reassembly libraries. Finally, we present the implementation and performance evaluation of four popular network traffic monitoring applications built on top of Scap.
Synthesis of Bridged Steroids. III. Cholestane Derivatives having a Bridged Bicyclo [2. 2. 2] octane Ring System of the Atisine Type (1968)

Synthesis of the cholestane derivative (V) having a bridged bicyclo [2. 2. 2] octane ring system of the atisine type was attained by various routes starting from 5α-cyanocholestan-3-one (II) as illustrated in Chart 4. The route through the ketal aldehyde (X) and 5α-vinylcholestan-3-one 3-ethylene ketal (XV), the key intermediate for the present synthesis, was found to be most advantageous. However, another route through the bridged acetoxy mesylate (XVI) is also thought to be important, since this intermediate is commonly used for the synthesis of the kaurene-type bridged ring compounds as decribed in the preceding paper. The allylic alcohol function of the atisine type was introduced at the corresponding position with opposite configuration of the hydroxy group giving compound (XXXVIII).
Optical Poling of Phenyl-Silica Hybrid Thin Films Doped with Azo-Dye Chromophore (1999)

Azo-dye doped phenly group substituted silica films were prepared by a sol-gel method from a solution of triethoxyphenlysilane (TEPh), tetraethoxysilane (TEOS) and 4-[N-ethyl-N-(2-hydroxyethyl)]amino-4 ′ -nitro-azobenzene (DR1). The films were optically poled by the coherent superposition of 1064 nm and 532 nm beams from a Q-switched Nd:YAG laser. Second-order susceptibility χ eff of a DR1 doped phenyl group substituted film induced by the optical poling was approximately four times as large as that of the phenyl-free film. The phenyl group in the silica matrix was found to be effective for increasing the second-order nonlinearity and increasing the thermal stability.
Mitochondria: are they the seat of senescence? (2003)

The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more correct number (0.1%) means that the production of O(2)(-) and H(2)O(2) in mitochondria is large and apt to result in damage to macromolecules in spite of such defensive enzymes as superoxide dismutases and glutathione peroxidase. The data available for nematodes and flies provide a compelling case for the view that the accumulation of oxidative damage to specific mitochondrial proteins leads to the progressive dysfunction that we see as senescence. The data available from work with mammals are much weaker and do not yet allow a strong position to be taken.
Comparison of Autologous Bone Marrow Mononuclear Cells Transplantation and Mobilization by Granulocyte Colony-Stimulating Factor in Experimental Spinal Injury (2012)

Background: Recent studies have shown that autologous adult stem cells may be a protocol of treatment for spinal cord injury (SCI) in humans. The purpose of this study was to compare the effect of an injection of autologous bone marrow mononuclear cells (BMMCs) and bone-marrow cell mobilization induced by granulocyte colony stimulating factor (G-CSF) in rats with SCI. Methods: Adult rats were assigned into three groups: control group (SCI only), SCI + BMMCs, and SCI + G − CSF. Neurological scores and electrophysiological testing were done in all rats before SCI, and at 1, 7, 14, 28, 56 days post-SCI. Simultaneously, immunohistochemical labeling and TUNEL assay were performed at the given time. Results: From 1 week post-SCI onward, animals treated with BMMCs or G-CSF had higher BBB scores than control group. Motor and somatosensory evoked potentials (MEPs and SEPs, respectively) of the treated group were significantly better than those in control group at 2 weeks. After sacrifice, compared with the control, animals treated with BMMCs and G-CSF significantly increased expressions of Brdu, NSE, GFAP, Factor VIII, BDNF, and reduced expression of apoptosis cells around the lesion site. Our results indicate that administration of BMMCs and G-CSF in a SCI model achieves similarly positive effect on functional and histologic recovery. Conclusions: The use of G-CSF may be a viable alternative to BMMCs for autograft in patients with SCI.