gebhart/patrepeval huggingface dataset:
Thermally stable, photoactive polymerizable diazenes. Applications in polymer technology (1999)

New and useful nonpolymerizable and polymerizable diazene free radical initiators have been designed, based on molecular orbital and empirical linear free energy calculations. The design of the polymerizable diazenes has been based on four requirements: independent reactivities of azo and vinyl moieties, high thermal stability of the trans-diazene isomers, efficient convertability of the trans isomer to the cis isomer, and high thermal reactivity (to produce free radicals) of the cis-diazene isomers. The cis-diazene isomers are obtained from the trans isomers by irradiation with visible light. A new free radical initiator has been shown to be useful in preparing graft copolymers and in crosslinking polymer chains by visible light activation. Poly(styrene-co-2-(meta-styrylazo)-2-methoxypropane) (2) was prepared by the copolymerization of styrene monomer and 2-(meta-styrylazo)-2-methoxypropane (1), either thermally or via a free radical initiator. Copolymer 2 then was reacted with methyl methacrylate monomer in the presence of visible light, to produce poly (styrene-g-methyl methacrylate) (6). Poly(styrene-co-2-(meta-styrylazo)-2-methylpropane) (17), prepared by the copolymerization of styrene monomer and 2-(meta-styrylazo)-2-methylpropane (15), was successfully crosslinked at elevated temperatures. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 3203–3213, 1999
Graph-based anomaly detection (2003)

Anomaly detection is an area that has received much attention in recent years. It has a wide variety of applications, including fraud detection and network intrusion detection. A good deal of research has been performed in this area, often using strings or attribute-value data as the medium from which anomalies are to be extracted. Little work, however, has focused on anomaly detection in graph-based data. In this paper, we introduce two techniques for graph-based anomaly detection. In addition, we introduce a new method for calculating the regularity of a graph, with applications to anomaly detection. We hypothesize that these methods will prove useful both for finding anomalies, and for determining the likelihood of successful anomaly detection within graph-based data. We provide experimental results using both real-world network intrusion data and artificially-created data.
Effectiveness of Percutaneous Neuromodulation Therapy for Patients with Chronic and Severe Low Back Pain (2003)

Abstract: Percutaneous neuromodulation therapy (PNT) is a minimally invasive approach to the treatment of low back pain (LBP), involving electrical stimulation applied to percutaneous electrodes placed within the lumbar paraspinal tissues during 30‐minute treatment sessions. This study reports the effects of PNT on a population of patients with chronic and severe levels of LBP. This study was performed in an outpatient clinical research setting. Thirty‐nine patients were enrolled who had stable levels of LBP lasting at least 6 months, with enrollment LBP visual analog scale (VAS) scores of at least 5 on a scale of 10. The patients were treated with PNT 2 times per week for 4 weeks. Baseline VAS scores of LBP, physical activity, sleep, and the Oswestry Questionnaire were recorded. The final assessment was made 48 hours after the last treatment. After 4 sessions, the patients completed a “responder screen” questionnaire whereby, to continue treatment, they had to indicate both a perceived benefit and improvement in LBP and/or activity levels. Thirty‐one patients completed the study protocol. Of the 18 patients (58% of 31) who passed the responder screen, 14 (78% of 18, 45% of 31) had ≥30% improvement in LBP and/or activity levels. Mean LBP scores decreased by 37% to 4.5 ± 2.2 from 7.1 ± 1.0 (P=0.0001); activity scores improved by 39% to 4.0 ± 2.1 from 6.7 ± 1.5 (P=0.0005); sleep scores improved by 40% from 6.2 ± 2.6 to 4.0 ± 2.6 (P=0.0003). Oswestry scores improved from 44 ± 12 to 33 ± 15 (P=0.002). In conclusion, for patients with chronic and severe stable levels of low back pain, PNT appears promising for pain level reduction and improvement in function.
Mechanism and BASIS for Specificity of Transglutaminase‐Catalyzed ε‐(γ‐Glutamyl) Lysine Bond Formation (1983)

Introduction Molecular Features and Catalytically Active Forms of the Transglutaminases Reactions Catalyzed by the Transglutaminases The Mechanism of Action of the Transglutaminases Substrate-Active Site Interactions and the Relationship of Conformations to Substrate Specificity and Catalysis Concluding Remarks
Reducing reservoir impacts and improving outcomes for dam‐forced resettlement: experiences in central Vietnam (2014)

Abstract The present study focuses on the growing problem of the impacts of human displacement resulting from hydropower dam construction, within the context of the integrated lake basin management of dam reservoirs. Dam‐forced displacement and resettlement can pose severe challenges to the environmental, economic and social sustainability of a reservoir basin. A case study in Quang Nam Province, central Vietnam, suggests that many resettled communities experience impoverishment due to the lack of adequate replacement land, declines in supplemental food sources and reduced access to natural resources. In response to such situations, resettled residents may (i) destroy lake catchment forests for the purpose of converting them to farmland or engage in illegal logging; (ii) increase agrichemical inputs on reduced land, thereby polluting run‐off and groundwater; and (iii) place increased pressure on fish stocks and wildlife. Examples are provided from central Vietnam to illustrate the need for applying management approaches that allows the affected people to become beneficiaries of dam projects and for including civil society organisations in resettlement planning. The hydropower authority can fund benefit‐sharing mechanisms, including village‐level electrification and payment for environmental services schemes, in which resettled populations are paid for forest maintenance and protection to prevent erosion and deforestation, and reservoir access can be provided for fishing, aquaculture and agriculture. Civil society organizations can advocate for residents’ interests and for reallocation of protected forest land for community forestry. These approaches can be supported by an inclusive reservoir management board working to achieve environmental sustainability, economic growth and social equity.
Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis (2014)

Caffeic acid (3,4-dihydroxycinnamic acid) is a well-known phenolic phytochemical present in coffee and reportedly has anticancer activities. However, the underlying molecular mechanisms and targeted proteins involved in the suppression of carcinogenesis by caffeic acid are not fully understood. In this study, we report that caffeic acid significantly inhibits colony formation of human skin cancer cells and EGF-induced neoplastic transformation of HaCaT cells dose-dependently. Caffeic acid topically applied to dorsal mouse skin significantly suppressed tumor incidence and volume in a solar UV (SUV)-induced skin carcinogenesis mouse model. A substantial reduction of phosphorylation in mitogen-activated protein kinase signaling was observed in mice treated with caffeic acid either before or after SUV exposure. Caffeic acid directly interacted with ERK1/2 and inhibited ERK1/2 activities in vitro. Importantly, we resolved the cocrystal structure of ERK2 complexed with caffeic acid. Caffeic acid interacted directly with ERK2 at amino acid residues Q105, D106, and M108. Moreover, A431 cells expressing knockdown of ERK2 lost sensitivity to caffeic acid in a skin cancer xenograft mouse model. Taken together, our results suggest that caffeic acid exerts chemopreventive activity against SUV-induced skin carcinogenesis by targeting ERK1 and 2.
Processing advances for localization of beaked whales using time difference of arrival (2013)

This paper is concerned with the localization of clicking Blainville's beaked whales (Mesoplodon densirostris) using an array of widely spaced bottom-mounted hydrophones. A set of signal and data processing advances are presented that together make reliable tracking a possibility. These advances include a species-specific detector, elimination of spurious time-difference-of-arrival (TDOA) estimates, improved tracking of TDOA estimates, positive association of TDOA estimates using different hydrophone pairs, and joint localization of multiple whales. A key innovation in three of these advances is the principle of click-matching. The methods are demonstrated using real data.
Widefield Optical Imaging of Changes in Uptake of Glucose and Tissue Extracellular pH in Head and Neck Cancer (2014)

The overall objective of this study was to develop an optical imaging approach to simultaneously measure altered cell metabolism and changes in tissue extracellular pH with the progression of cancer using clinically isolated biopsies. In this study, 19 pairs of clinically normal and abnormal biopsies were obtained from consenting patients with head and neck cancer at University of California, Davis Medical Center. Fluorescence intensity of tissue biopsies before and after topical delivery of 2-NBDG (2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose) and Alexa 647-pHLIP [pH (low) insertion peptide] was measured noninvasively by widefield imaging, and correlated with pathologic diagnosis. The results of widefield imaging of clinical biopsies demonstrated that 2-NBDG and pHLIP peptide can accurately distinguish the pathologically normal and abnormal biopsies. The results also demonstrated the potential of this approach to detect subepithelial lesions. Topical application of the contrast agents generated a significant increase in fluorescence contrast (3- to 4-fold) in the cancer biopsies as compared with the normal biopsies, irrespective of the patient and location of the biopsy within a head and neck cavity. This unpaired comparison across all the patients with cancer in this study highlights the specificity of the imaging approach. Furthermore, the results of this study indicated that changes in intracellular glucose metabolism and cancer acidosis are initiated in the early stages of cancer, and these changes are correlated with the progression of the disease. In conclusion, this novel optical molecular imaging approach to measure multiple biomarkers in cancer has a significant potential to be a useful tool for improving early detection and prognostic evaluation of oral neoplasia.
Interactions in vitro of p9Ka, the rat S-100-related, metastasis-inducing, calcium-binding protein. (1994)

The S-100 proteins are a structurally related family displaying diverse intracellular and extracellular interactions. One such protein p9Ka (also known as calvasculin), or its mRNA (also known as CAPL, 42A, 18A2, mts, pEL 98), becomes elevated upon changes in the growth and differentiation of cells. Overexpression of p9Ka in benign rat mammary cells induces the metastatic phenotype. In order to help understand the role of p9Ka in these processes, the molecular properties of recombinant rat p9Ka have been studied. Recombinant p9Ka forms multimers in vitro, which are not due to intermolecular disulfide bridges, it binds 2 mol of calcium ions/mol of protein, and the binding of calcium ions is strongly antagonized by monovalent and divalent cations tested. Immunofluorescence studies indicate that p9Ka is located on cytoskeletal elements in a pattern which is identical to actin filaments stained with phalloidin. In vitro, it is shown that recombinant p9Ka binds to sites on at least two intracellular polypeptides. These sites display the same binding capacity for p9Ka in extracts of cultured rat mammary cells which show widely differing levels of expression of natural p9Ka. The results suggest that the production of p9Ka, and not of its target molecules, may be associated with the changes seen in cultured cells.
Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V (2015)

Myosins use a conserved structural mechanism to convert the energy from ATP hydrolysis into a large swing of the force-generating lever arm. The precise timing of the lever arm movement with respect to the steps in the actomyosin ATPase cycle has not been determined. We have developed a FRET system in myosin V that uses three donor-acceptor pairs to examine the kinetics of lever arm swing during the recovery and power stroke phases of the ATPase cycle. During the recovery stroke the lever arm swing is tightly coupled to priming the active site for ATP hydrolysis. The lever arm swing during the power stroke occurs in two steps, a fast step that occurs before phosphate release and a slow step that occurs before ADP release. Time-resolved FRET demonstrates a 20-Å change in distance between the pre- and postpower stroke states and shows that the lever arm is more dynamic in the postpower stroke state. Our results suggest myosin binding to actin in the ADP.Pi complex triggers a rapid power stroke that gates the release of phosphate, whereas a second slower power stroke may be important for mediating strain sensitivity.
Results of Long-Term Iron-Chelating Therapy (1996)

The improvement in survival and quality of life of iron-overloaded patients achieved by regular subcutaneous chelation has been extensively documented over the years. A review of the long-term results allows one to establish the following points: (1) with regular subcutaneous chelation, a negative iron balance can be obtained in most patients, except very young ones; (2) severe deferoxamine (DFO) toxicity may be prevented by skipping high doses and by carefully monitoring and modulating chelation, especially in patients with a low iron overload; (3) the maintenance of compliance with DFO over 0.6 and of ferritin levels below 2,000 prevents iron overloaded complications, at least for the first 20 years of life; (4) long-term chelation can reverse functional complications such as liver fibrosis, arrhythmia and echocardiographic abnormalities, but not complications due to extensive tissue alterations, such as frank diabetes, hypothyroidism and myocardiosclerosis; (5) intensive intravenous protocols can be successfully applied in heavily overloaded patients and represent the only possibility to reverse their dangerous iron burden in a relatively short period of time; (6) survival and quality of life in well-chelated patients are approaching a normal pattern, and (7) clinical outcome and prognosis are better evaluated by parameters that consider iron overload and chelation trends.
Union wage setting in a dual labour market: the role of centralisation (2008)

This paper analyses the centralisation of union wage bargaining when the workers’ outside option is determined endogenously. A dual labour market model is developed where the wage rate in the first sector is either the result of decentralised bargaining at the firm level or of centralised bargaining at the sector level. Workers’ outside option is employment in a competitive sector. Labour market outcome depends on whether the union takes into account the connection between wages in both sectors. Wage setting centralisation increases social welfare if union's bargaining power at the firm level is relatively high and/or the union at the sector level represents a relatively large number of workers.
Swim stress, motion, and deformation of active matter: effect of an external field (2014)

We analyze the stress, dispersion, and average swimming speed of self-propelled particles subjected to an external field that affects their orientation and speed. The swimming trajectory is governed by a competition between the orienting influence (i.e., taxis) associated with the external (e.g., magnetic, gravitational, thermal, nutrient concentration) field versus the effects that randomize the particle orientations (e.g., rotary Brownian motion and/or an intrinsic tumbling mechanism like the flagella of bacteria). The swimmers' motion is characterized by a mean drift velocity and an effective translational diffusivity that becomes anisotropic in the presence of the orienting field. Since the diffusivity yields information about the micromechanical stress, the anisotropy generated by the external field creates a normal stress difference in the recently developed "swim stress" tensor [Takatori, Yan, and Brady, Phys. Rev. Lett., 2014]. This property can be exploited in the design of soft, compressible materials in which their size, shape, and motion can be manipulated and tuned by loading the material with active swimmers. Since the swimmers exert different normal stresses in different directions, the material can compress/expand, elongate, and translate depending on the external field strength. Such an active system can be used as nano/micromechanical devices and motors. Analytical solutions are corroborated by Brownian dynamics simulations.
Performance analysis of slotted ring protocols in HSLANs (1988)

The performance of a number of slotted-ring protocols supporting integration of synchronous and asynchronous traffic in high-speed local area networks (HSLANs) is evaluated. They are the Cambridge fast ring, a variant of the Cambridge fast ring, and Orwell. The performance of their basic access mechanisms is compared and contrasted with that of the multiple-token ring. The effect of a uniframe scheme for supporting synchronous traffic is examined. A delay analysis of the integrated-services slotted-ring protocols is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases (2011)

PAI-1 inhibitors appear to exhibit potent effects on the prevention of adverse tissue remodeling. However, PAI-1 is a multifunctional protein and more research is needed to further elucidate the association between PAI-1 expression and cardiovascular disease.
Genetics of Cardiovascular Disease in the Young (2012)

This chapter contains sections titled: Introduction What is the incidence of CVMs? Cause of CVMs: understanding in the pregenomic era Cause of CVMs: understanding in the postgenomic era Definition of the phenotype Evidence of genetic origins Study design for CVM gene discovery Methods for genotyping Statistical approaches to gene discovery Prioritizing statistical approaches Strategies for finding genes given complex inheritance Novel genotyping technology - moving beyond SNPs Causality Conclusion References
A fast distance approximation algorithm for encoded quadtree locations (2002)

Several distance approximation functions to the Euclidean distance of two points in the two-dimensional Euclidean plane are reviewed. An improved distance function is proposed and compared with previous ones as to their maximum relative errors and their execution times. The improved distance function is then applied for distance calculations in the domain of linear quadtrees using dilated integer arithmetic. The maximum relative error is discussed and execution times are reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
4-1BB enhancement of CAR T function requires NF-κB and TRAFs (2018)

Chimeric antigen receptors (CARs) have an antigen-binding domain fused to transmembrane, costimulatory, and CD3ζ domains. Two CARs with regulatory approval include a CD28 or 4-1BB costimulatory domain. While both CARs achieve similar clinical outcomes, biologic differences have become apparent but not completely understood. Therefore, in this study we aimed to identify mechanistic differences between 4-1BB and CD28 costimulation that contribute to the biologic differences between the 2 CARs and could be exploited to enhance CAR T cell function. Using CD19-targeted CAR T cells with 4-1BB we determined that enhancement of T cell function is driven by NF-κB. Comparison to CAR T cells with CD28 also revealed that 4-1BB is associated with more antiapoptotic proteins and dependence on persistence for B cell killing. While TNF receptor-associated factor 2 (TRAF2) has been presupposed to be required for 4-1BB costimulation in CAR T cells, we determined that TRAF1 and TRAF3 are also critical. We observed that TRAFs impacted CAR T viability and proliferation, as well as cytotoxicity and/or cytokines, in part by regulating NF-κB. Our study demonstrates how 4-1BB costimulation in CAR T cells impacts antitumor eradication and clinical outcomes and has implications for enhanced CAR design.
Enhancing IEEE 802.15.4 for low-latency, bandwidth, and energy critical WSN applications (2008)

The recently standardized IEEE 802.15.4 protocol is emerging as a basic building block for wireless sensor network applications by providing many appealing features, such as low power, low cost, low data-rate, and simplicity. However, when treating applications with strict timeliness, energy, and bandwidth requirements several problems arise, triggering the need of a solution for an efficient twinning of IEEE 802.15.4 and wireless sensor networks. In this paper, after discussing the working of IEEE 802.15.4, we point out its limitations for such applications and propose a solution to overcome those limitations. We also derive an efficient IEEE 802.15.4-based network parameters setting to improve the network performance in terms of latency, energy, and bandwidth utilization.
Cavity ring-down spectroscopy: Experimental schemes and applications (2000)

Cavity ring-down (CRD) spectroscopy is a direct absorption technique, which can be performed with pulsed or continuous light sources and has a significantly higher sensitivity than obtainable in conventional absorption spectroscopy. The CRD technique is based upon the measurement of the rate of absorption rather than the magnitude of absorption of a light pulse confined in a closed optical cavity with a high Q factor. The advantage over normal absorption spectroscopy results from, firstly, the intrinsic insensitivity to light source intensity fluctuations and, secondly, the extremely long effective path lengths (many kilometres) that can be realized in stable optical cavities. In the last decade, it has been shown that the CRD technique is especially powerful in gas-phase spectroscopy for measurements of either strong absorptions of species present in trace amounts or weak absorptions of abundant species. In this review, we emphasize the various experimental schemes of CRD spectroscopy, and we show how these schemes can be used to obtain spectroscopic information on atoms, molecules, ions and clusters in many environments such as open air, static gas cells, supersonic expansions, flames and discharges.
<i>Cambio de piel</i>: Literature and Evil (1989)

BSS Subject Index: CAMBIO DE PIEL [C. FUENTES]EVIL/DEVIL [AS LITERARY/CULTURAL THEME]FUENTES, CARLOS (b. 1928)
THE COMPARATIVE STUDY IN THE OXYGEN ATOM TRANSFER REACTION BY RUTHENIUM MONO-OXO COMPLEXES (1998)

The oxidation of triphenylphosphine by [(tpy)(phen)RuⅣ(O)]2+ and [(bpy)(p-tert-butylpy)RuⅣ(0)]2+ (tpy is 2,2': 6',2-terpyridine, phen is 1,10-phenanthroline, bpy is 2,2'-bipyridine, and p-tert-butylpy is para-tertbutylpyridine) in CH3CN has been studied. Experiments using 18O-labeled complex show the oxyl group transfer from [RuⅣ=O]2+ to triphenylphosphine occured quantitatively within experimental error. Kinetic data were fit to a second-order for [RuⅣ=O]2+ and [PPh3]. The initial product, [RuⅡ-OPPh3]2+, was formed as an observable intermediate and then underwent slow solvolysis. The reaction proceeded as endothermic in activation enthalpy and a decrease in activation entropy. The oxidative reactivity of four representative ruthenium mono-oxo oxidants against triphenylphosphine was compared. These systems have been utilized as electrochemical oxidative catalysts.