gebhart/patrepeval huggingface dataset:
Evaluation of immunoglobulin E-specific antibodies and viral antigens in nasopharyngeal secretions of children with respiratory syncytial virus infections (1993)

Enzyme immunoassays were developed to detect the presence of specific immunoglobulin E (IgE) antibodies and respiratory syncytial (RS) virus structural proteins in nasopharyngeal secretions in order to improve the knowledge on some aspects of the pathogenesis of severe acute lower respiratory tract infections caused by RS virus. These assays were used to analyze clinical specimens from children with RS virus-associated infections (bronchiolitis and pneumonia), and the findings were correlated with the patients' clinical symptoms. The results indicate the presence of specific IgE against the two external glycoproteins (G and F) and the absence of detectable IgE levels for the internal viral antigens. There was a correlation between the levels of IgE-specific antibodies and the amount of viral protein F in the secretions, indicating that the IgE response against the viral glycoproteins might be related to the antigen load. In addition, a correlation was found between higher levels of both viral protein F-specific IgE and F antigen with higher respiratory rates in children with pneumonia. These findings may be relevant because they suggest an association between the virus load and the immune response in the pathogenesis of RS virus infections.
Chondrogenic Potential of Multipotential Cells from Human Adipose Tissue (2004)

The use of stem cells for cell-based tissue-engineering strategies represents a promising alternative for the repair of cartilaginous defects. The multilineage potential of a population of putative mesodermal stem cells obtained from human lipoaspirates, termed processed lipoaspirate cells, was previously characterized. The chondrogenic potential of those cells was confirmed with a combination of histological and molecular approaches. Processed lipoaspirate cells under high-density micromass culture conditions, supplemented with transforming growth factor-beta1, insulin, transferrin, and ascorbic acid, formed well-defined nodules within 48 hours of induction and expressed the cartilaginous markers collagen type II, chondroitin-4-sulfate, and keratan sulfate. Reverse transcription polymerase chain reaction analysis confirmed the expression of collagen type II and the cartilage-specific proteoglycan aggrecan. In summary, human adipose tissue may represent a novel plentiful source of multipotential stem cells capable of undergoing chondrogenesis in vitro.
Study of Water Detecting Sensor in Insulated Gas of GIS/GCB Elctrochemical Sensor Using Ttriethlenediaminesulfate as Electrolyte (2010)

Water Detecting Sensor using solid state protonic conductor has been developed for Gas Insulated Swicthgear. Ttriethlenediaminesulfate was selected as protonic conductor with which elcterochemical sensor was constructed. The water detecting characteristics and its reliabilities were examined. The sensor detected water concentration from several ppm to about 2000ppm (at 5ata) as an output electric current, and was able to detect sufficiently water of 50ppm (at 5ata) which was the targeted value of the sensor. The mechanical strength increased by adding a polymer in the electrolyte. We also examined the influence to an output characteristic by the polymer addition and reliability. We proposed that without heating process was preferable in constructing sensor.
Origins of the impedance change in impedance cardiography by a three-dimensional finite element model (1988)

A three-dimensional finite-element model of the thorax and neck using eight-node trilinear hexahedron elements was constructed to investigate the impedance change associated with various physiological events during systole. A three-dimensional finite-element code was developed to solve the generalized Laplace equation with Dirichlet and homogeneous Neumann boundary conditions. The current in each element as well as potential at each node was calculated. The results suggest that an approximately linear relationship exists between the impedance change and blood volume change in the aorta. This is a promising result since the relationship helps explain the correlation between impedance cardiography and invasive techniques. Impedance changes due to blood volume changes in the aorta and ventricles, the lung-resistivity change, and the blood-resistivity change were calculated for standard impedance electrode configurations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Botany (1948)

The weekend of June 11-14 the museum went north on a photographic trip for the Department of Natural Resources.With them went Dr, G, F, Ledingham, Re^^ina College Biologist and President of the Reg^ina Natural History Society, Durin^, the trip he collected and pressed about one hundred plants.The main stons were at Beaver Creek, about twenty miles south of Saskatoon, and along the creek north of Shell lake, which is about forty miles west of Prince Albert.The Department of Natural Resources and the Fish Board again provided transportation for Dr. Leding^ham from June 25 to July 1st and 220 plants were collected.The main stops on this trip, which was mostly made by air, were Prince Albert, Lac La Ronge, Wollaston Post, Tate Island in Reindeer Lake and Amisk Lake (15 miles east of Flin Flon).Many interesting, plants were seen.Outstanding amongst these were the Galla Lily, the Pale Laurel
TACI regulates IgA production by APRIL in collaboration with HSPG (2006)

Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL). Although TACI is reported to function as a positive or negative regulator for B-cell responses, its roles remain elusive. Experiments using TACI siRNA into B cells indicated that TACI positively regulated APRIL-induced IgA production in collaboration with heparan sulfate proteoglycans (HSPG). Furthermore, TACI negatively regulated BAFF-induced B-cell proliferation and production of IgA and IgG. In addition, B cells treated with heparitinase to denature HSPG showed that HSPG is essential for APRIL-induced B-cell responses such as B-cell proliferation, IgG and IgA production, induction of activation-induced cytidine deaminase (AID), and noncanonical NF-kappaB2. In contrast, phosphorylation of physiological AID kinase, protein kinase A (PKA), was dependent on TACI. Importantly, coligation of TACI and HSPG by specific antibodies, but not by TACI or HSPG ligation itself, could induce the phosphorylation of PKA and IgA production instead of APRIL. Our findings indicate that simultaneous binding of TACI and HSPG on B cells with APRIL is crucial for IgA production.
A machine learning approach to understand business processes (2003)

Business processes (industries, administration, hospitals, etc.) become nowadays more and more complex and it is difficult to have a complete understanding of them. The goal of the thesis is to show that machine learning techniques can be used successfully for understanding a process on the basis of data, by means of clustering process related measures, induction of predictive models, and process discovery. This goal is achieved by means of two approaches: (i) classify process cases (e.g. patients) into logistic homogeneous groups and induce models that assign a new case to a logistic group and (ii) discover the underlying process. By doing so, the process can be modelled, analysed and improved. Another benefit is that systems can be designed more efficiently to support and control the processes more effectively. We target on the analysis of two sorts of data, namely aggregated data and sequence data. Aggregated data result from performing some transformations on raw data, focusing on a specific concept, that is not yet explicit in the raw data. This aggregation is similar to feature construction, as used in the machine learning domain. In this thesis, aggregated data are the variables that result from operationalizing the concept of process complexity. These aggregated data are used to develop logistic homogeneous clusters. This means that elements in different clusters will differ from the routing complexity point of view. We show that developing homogeneous clusters for a given process is relevant in connection with the induction of predictive models. Namely, the routing in the process can be predicted using the logistic clusters. We do not aim to provide concrete directives for building control systems, rather our models should be taken as indicatives of their potential. Sequence data describe the sequence of activities over time in a process execution. They are recorded in a process log, during the execution of the process steps. Due to exceptions, missing or incomplete registration and errors, the data can be noisy. By using sequence data, the goal is to derive a model explaining the events recorded. In situations without noise and sufficient information, we provide a method for building a process model from the process log. Moreover, we discuss the class of models for which it is possible to accurately rediscover the model by looking at the process log. Machine learning techniques are especially useful when discovering a process model from noisy sequence data. Such a model can be further analyzed and eventually improved, but these issues are beyond the scope of this thesis. Through the applications of our proposed methods on different data (e.g. hospital data, workflow data and administrative governmental data), we have shown that our methods result in useful models and subsequently can be used in practice. We applied our methods on data-sets for which (i) it was possible to aggregate relevant information and (ii) sequence data were available.
Cyclam complexes and their applications in medicine (2004)

Cyclams are 14-membered tetraamine macrocycles which bind strongly to a wide range of metal ions. Medical interest has centred on clinical trials of a bicyclam for the treatment of AIDS and for stem cell mobilization, and on adducts with Tc and Cu radionuclides for diagnosis and therapy. Other potential applications particularly for Cr, Mn, Zn, and Ru cyclams are also emerging. We discuss in this critical review the mechanism of metal complexation, stability of metal cyclams and their structures, with particular emphasis on the variety of configurational states which metal cyclams can adopt. Understanding the factors which control the thermodynamics and kinetics of the interconversion of configurational states of metallo-cyclams may be a key factor in designing novel cyclam derivatives for future use in medicine.
Optimization of Extraction of Circulating RNAs from Plasma – Enabling Small RNA Sequencing (2014)

There are several protocols and kits for the extraction of circulating RNAs from plasma with a following quantification of specific genes via RT-qPCR. Due to the marginal amount of cell-free RNA in plasma samples, the total RNA yield is insufficient to perform Next-Generation Sequencing (NGS), the state-of-the-art technology in massive parallel sequencing that enables a comprehensive characterization of the whole transcriptome. Screening the transcriptome for biomarker signatures accelerates progress in biomarker profiling for molecular diagnostics, early disease detection or food safety. Therefore, the aim was to optimize a method that enables the extraction of sufficient amounts of total RNA from bovine plasma to generate good-quality small RNA Sequencing (small RNA-Seq) data. An increased volume of plasma (9 ml) was processed using the Qiagen miRNeasy Serum/Plasma Kit in combination with the QIAvac24 Plus system, a vacuum manifold that enables handling of high volumes during RNA isolation. 35 ng of total RNA were passed on to cDNA library preparation followed by small RNA high-throughput sequencing analysis on the Illumina HiSeq2000 platform. Raw sequencing reads were processed by a data analysis pipeline using different free software solutions. Seq-data was trimmed, quality checked, gradually selected for miRNAs/piRNAs and aligned to small RNA reference annotation indexes. Mapping to human reference indexes resulted in 4.862.8% of mature miRNAs and 1.460.8% of piRNAs and of 5.062.9% of mature miRNAs for bos taurus.
Constructing 3D natural scene from video sequences with vibrated motions (2002)

This paper presents a systematic approach to automatically construct 3D natural scenes from video sequences. Dense layered depth maps are derived from image sequences captured by a vibrated camera with only approximately known motion. The approach consists of (1) image stabilization by motion filtering and (2) depth estimation by spatio-temporal texture analysis. The two stage method not only generalized the so called panoramic image method and epipolar plane image method to handle image sequence vibrations due to the uncontrollable camera fluctuations, but also bypasses the feature extraction and matching problems encountered in stereo or visual motion. Our approach allows automatic modeling of the real environment for inclusion in VR representations.
Nonlinear effects and Joule heating in I-V curves in manganites (2005)

We study the influence of the Joule effect on the nonlinear behavior of the transport I-V curves in polycrystalline samples of the manganite Pr0.8Ca0.2MnO3 by using the crystalline unit-cell parameters as an internal thermometer in x-ray and neutron diffractions. We develop a simple analytical model to estimate the temperature profile in the samples. Under the actual experimental conditions we show that the internal temperature gradient or the difference between the temperature of the sample and that of the thermal bath is at the origin of the nonlinearity observed in the I-V curves. Consequences on other compounds with colossal magnetoresistance are also discussed.
Automatic optical loss compensation with erbium-doped fiber amplifier (1992)

The effect of unwanted optical loss varying over 15 dB is automatically offset with an erbium-doped fiber amplifier used in an optical feedback configuration. The loss compensation is possible for signal wavelengths over a 13 nm range centered at about 1550 nm. The system dynamic range for loss fluctuation frequencies is zero to several kilohertz. The proposed loss compensation scheme simultaneously provides an automatic gain control function that stabilizes the gain against slow changes in input signal power or pump power.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Hybrid Integrated Pulsewidth Modulator (1972)

A hybrid integrated circuit is described which generates two phase-shifted 20-kHz output pulse trains whose duty cycles are related to the amplitude of an applied input signal. The circuit was designed primarily for use in power conditioning schemes utilizing pulsewidth modulated signals for regulated dc-to-dc voltage conversion. Realization of this hybrid circuit has been accomplished with a beam-lead sealed-junction monolithic silicon chip and several tantalum thin-film resistors and capacitors which are bonded/ deposited on a ceramic substrate in the form of a 28-terminal dual-in line package (DIP).
GLOpenCL (2011)

OpenCL is an industry supported standard for writing programs that execute on multicore platforms as well as on accelerators, such as GPUs or the SPEs of the Cell B.E. In this paper we introduce GLOpenCL, a unified development framework which supports OpenCL on both homogeneous, shared memory, as well as on heterogeneous, distributed memory multicores. The framework consists of a compiler, based on the LLVM compiler infrastructure, and a run-time library, sharing the same basic architecture across all target platforms. The compiler recognizes OpenCL constructs, performs source-to-source code transformations targeting both efficiency and semantic correctness, and adds calls to the run-time library. The latter offers functionality for work creation, management and execution, as well as for data transfers. We evaluate our framework using benchmarks from the distributions of OpenCL implementations by hardware vendors. We find that our generic system performs comparably or better than customized, platform-specific vendor distributions. OpenCL is designed and marketed as a write-once run-anywhere software development framework. However, the standard leaves enough room for target platform specific optimizations. Our experimentation with different, customized implementations of kernels reveals that optimized, hardware mapped implementations are both possible and necessary in the context of OpenCL -- especially on non-conventional multicores -- if performance is considered a higher priority than programmability.
Blausteinʼs Pathology of the Female Genital Tract. Fourth Edition. Edited (1995)

New York: Springer-Verlag, 1994, 1280 pp., $155.00. Department of Pathology UCLA Medical Center Los Angeles, California, 90024, U.S.A.
Flux pinning in Al doped TSMG YBCO bulk superconductors (2009)

International audience
Relationships between Reduction Properties and Cancer Cell Growth Inhibitory Activities of cis-Dichloro- and cis-Diiodo-Pt(IV)-ethylenediamines (1999)

The chemical reactivities and cancer cell growth inhibitory activities of a new series of cis-diiodo-Pt(IV)-ethylenediamines were compared and contrasted with their cis-dichloro-Pt(IV)-counterparts. cis-Diiodo-Pt(IV)-ethylenediamines bearing various axial ligands (i.e., OH, OAc, OCOCF3, OSO2CH3) were prepared by oxidizing [PtI2(en)] with 30% H2O2 to yield trans,cis-[PtOH2I2(en)], which was then reacted with either Ac2O, (CF3CO)2O, or (SO2CH3)2O in CH2Cl2. The cis-diiodo-Pt(IV) complexes were readily reduced by biological thiols such as L-cysteine, glutathione (GSH), and bovine serum albumin (BSA) at pH 6.9 and 37 °C; the kinetics of reduction were second-order with respect to thiol concentration. In contrast, the cis-dichloro analogues were stable in the presence of GSH. The reduction potentials estimated by means of cyclovoltammetry for the Pt(IV) complexes are useful for obtaining a ranking order of reactivity towards biological thiols; however, the reduction potentials alone cannot be used to predict whether a Pt(IV) complex will be reduced by GSH at biologically relevant concentrations. GSH greatly facilitated the platination of calf thymus DNA by the diiodo-Pt(IV) complexes, which was >90% complete after 24 h at 37 °C when the ratio of GSH to Pt(IV) was 2:1. DNA-platination by trans,cis-[Pt(OH)2I2(en)] and trans,cis-[Pt(OAc)2I2(en)] were dependent on the presence of GSH while trans,cis-[Pt(OSO2CH3)2I2(en)] showed 23% DNA platination after 24 h in the absence of GSH. In contrast, the dichloro analogues trans,cis-[Pt(OH)2Cl2(en)] and trans,cis-[Pt(OAc)2Cl2(en)] failed to react with DNA in the presence of either low (0.015 mM) to high (3.0 mM) concentrations of GSH. Cell culture experiments with four human cancer cell lines showed that the maximal growth inhibitory activity of the cis-diiodo-Pt(IV)-ethylenediamines was reached within a 24 h exposure to platinum complex, while the dichloro-Pt(IV) analogues required a much longer drug-exposure time (i.e., 96 h) to reach maximal activity.
Delay-Sensitive Communication Over Fading Channels: Queueing Behavior and Code Parameter Selection (2014)

This paper examines the queueing performance of communication systems that transmit encoded data over unreliable channels. A fading formulation suitable for wireless mobile applications is considered, where errors are caused by a discrete channel with correlated behavior over time. For carefully selected channel models and arrival processes, a tractable Markov structure composed of queue length and channel state is identified. This facilitates the analysis of the stationary behavior of the system, leading to evaluation criteria such as bounds on the probability of the queue exceeding a threshold. Specifically, this paper focuses on system models with scalable arrival profiles, which are based on Poisson processes, and finite-state channels with memory. These assumptions permit the rigorous comparison of system performance for codes with arbitrary block lengths and code rates. Based on the resulting characterizations, it is possible to select the best code parameters for delay-sensitive applications over various channels. Random codes and BCH codes are then employed as a means to study the relationship between code parameter selection and the queueing performance of point-to-point data links. The methodology introduced herein offers a new perspective on the joint queueing-coding analysis of finite-state channels with memory, and it is supported by numerical simulations.
A Distributed Botnet Detecting Approach Based on Traffic Flow Analysis (2012)

Bonnet is extremely harmful to computer network security which could cause many network attacks(like spam, DDoS, phishing etc). In this paper, we design a distributed Bonnet detecting approach based on network traffic analysis. A botnet detection framework is proposed, which composed of two sections: Data Collection and Filter, Bonnet Detection and Identify. The first section is deployed in distributed hosts in order to capture network traffic data, filter data and classify data. The second section is deployed in centralized place which collectes all data from distributed hosts and detected the botnet using data amalgamation algorithms and characteristic identified algorithms. The detecting approach works efficiently and can detect botnet in the experiment environment.
The Production of Anhydrous Magnesium Chloride (1940)

A study was made of the direct chlorination of magnesium oxide in the presence of carbon, producing anhydrous magnesium chloride suitable for the fused electrolyte process in the magnesium metal industry. Conditions were established under which (a) briquettes of magnesium oxide and carbon and (b) granular mixture of magnesium oxide and carbon could be successfully chlorinated. The differences in the manner in which granular material and briquettes must be treated in order to achieve complete conversion to oxide‐free chloride are pointed out. Granular magnesium oxide of low bulk density may be considered as a preferred material for the production of anhydrous magnesium chloride.
Development of Catalytic Asymmetric Acylation of Alcohols in the Presence of a Chiral 1,2-Diamine. (1999)

Asymmetric acylation of alcohols is very important in synthetic organic chemistry and holds great potential for the preparation of small chiral compounds which are suited for further manipulation in the synthesis of biologically active natural products. Although enzymatic acylation has been extensively studied and established as a promising method for the preparation of chiral alcohol variants, development of nonenzymatic alternatives in this field has been scattered. From this viewpoint, we wish to demonstrate highly efficient and practical methods for the catalytic asymmetric acylation of racemic secondary alcohols and various meso-diols by the reaction with achiral benzoyl chloride in the presence of a chiral 1, 2-diamine derived from (S) -proline.