gebhart/patrepeval huggingface dataset:
Skeletal Muscle–Derived CD34 <sup>+</sup> /45 <sup>-</sup> and CD34 <sup>-</sup> /45 <sup>-</sup> Stem Cells Are Situated Hierarchically Upstream of Pax7 <sup>+</sup> Cells (2008)

The hierarchical relationship of skeletal muscle-derived multipotent stem cells sorted as CD34(+)/CD45(-) (Sk-34) and CD34(-)/CD45(-) (Sk-DN) cells, which have synchronized reconstitution capacities for blood vessels, peripheral nerves, and muscle fibers, was examined. Expression of Sca-1 and CD34 (typical state of freshly isolated Sk-34 cells) in Sk-DN cells was examined using in vitro culture and in vivo cell implantation. Sk-DN cells sequentially expressed Sca-1 and CD34 during cell culture showing self-maintenance and/or self-renewal-like behavior, and are thus considered hierarchically upstream of Sk-34 cells in the same lineage. Sk-34 and Sk-DN cells were further divided into small and large cell fractions by cell sorting. Immunocytochemistry using anti-Pax7 was performed at the time of isolation (before culture) and revealed that only 1% of cells in the large Sk-DN cell fraction were positive for Pax7, while Sk-34 cells and 99% of Sk-DN cells were negative for Pax7. Therefore, putative satellite cells were possibly present in the large Sk-DN cell fraction. However, serial analysis of Pax7 expression by RT-PCR and immunocytochemistry for single and 2 to >40 clonally proliferated Sk-34 and Sk-DN cells revealed that both cell types expressed Pax7 after several asymmetric cellular divisions during clonal-cell culture. In addition, production of satellite cells was seen after muscle fiber formation following Sk-34 or Sk-DN cell transplantation into damaged muscle, and even in the nonmuscle tissue environment (beneath the renal capsule). Thus, Sk-DN cells are situated upstream of Sk-34 cells and both cells can produce Pax7+ cells (putative satellite cells) after cellular division.
Clonal and molecular characteristics of the human IgE-committed B cell subset. (1989)

We have followed the pathway of the IgE-committed B lymphocyte from fresh, unstimulated peripheral blood, through EBV activation, transformation, and eventual cloning. Using cell sorting in conjunction with limiting dilution culture systems, we found that: (a) cells that are selected in the cell sorter and secrete IgE in culture are sIgM+/sIgD+. They secrete all three isotypes after EBV activation and continue to do so stably in culture; (b) individual IgE+ cells in culture coproduce IgM, IgD, and IgE and cytoplasmic Ig of each isotype can be detected in single cells; (c) no rearrangement was observed of VDJ to epsilon in any of six lines tested. DNA between the rearranged VDJ-mu and -epsilon appears to be overall intact, including a region 10.5 kb upstream and 18 kb downstream of the 2-kb epsilon coding region and; (d) mRNA of mu and epsilon species is of normal and comparable size. In contrast to IgG- and IgA-producing clones, multiple isotype expression appears to be both frequent and stable in cells committed to IgE production. We propose that IgE-committed cells represent a unique B cell sublineage whose differentiation pathway may be more strictly regulated than that of other isotypes with regard to the signals required for classical, deletional switch recombination that has been observed in rare IgE-producing myeloma cell lines.
Effect of Ultrasonic Treatment on Highly Hydrophilic TiO<sub>2</sub> Surfaces (1998)

Glass surfaces coated with polycrystalline titanium dioxide (TiO2) films were found to exhibit a 0° water contact angle when the surfaces were illuminated with UV light in the air. This highly hydrophilic surface was maintained for more than 1 week in the dark in air. However, ultrasonic treatment in pure water decreased the degree of surface hydrophilicity, yielding a contact angle of approximately 11°. X-ray photoelectron spectroscopic measurements indicated that hydroxyl groups and molecular water adsorption, which govern the surface wettability, were partially removed from the surface by the ultrasonic treatment. The effect of ultrasonic treatment was ascribed to the generation of OH radicals that reoxidized the photoreduced surface, accompanied by the removal of surface-adsorbed water. This has been confirmed by adding acrylamide, a typical OH radical scavenger, to pure water to effectively suppress the hydrophilic-to-hydrophobic reconversion on the TiO2 surface.
Measles Virus Targets DC-SIGN To Enhance Dendritic Cell Infection (2006)

Dendritic cells (DCs) are involved in the pathogenesis of measles virus (MV) infection by inducing immune suppression and possibly spreading the virus from the respiratory tract to lymphatic tissues. It is becoming evident that DC function can be modulated by the involvement of different receptors in pathogen interaction. Therefore, we have investigated the relative contributions of different MV-specific receptors on DCs to MV uptake into and infection of these cells. DCs express the MV receptors CD46 and CD150, and we demonstrate that the C-type lectin DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is a novel receptor for laboratory-adapted and wild-type MV strains. The ligands for DC-SIGN are both MV glycoproteins F and H. In contrast to CD46 and CD150, DC-SIGN does not support MV entry, since DC-SIGN does not confer susceptibility when stably expressed in CHO cells. However, DC-SIGN is important for the infection of immature DCs with MV, since both attachment and infection of immature DCs with MV are blocked in the presence of DC-SIGN inhibitors. Our data demonstrate that DC-SIGN is crucial as an attachment receptor to enhance CD46/CD150-mediated infection of DCs in cis. Moreover, MV might not only target DC-SIGN to infect DCs but may also use DC-SIGN for viral transmission and immune suppression.
Intersubband χ/sup 3/ in coupled InGaAs-AlGaAs multiple quantum wells (1998)

The third-order nonlinearity, /spl chi//sup 3/(/spl omega/,/spl omega/,-/spl omega/), is measured for a mid-infrared intersubband transition in strained InGaAs-AlGaAs multiple quantum wells (MQW's). The high conduction band offset of this system allows an intersubband transition at 3.1 /spl mu/m. The level structure of the quantum well is designed to include a meta-stable trapping level, resulting in a peak saturation intensity of 6 MW/cm/sup 2/ at Brewster's angle, approximately 20 times lower than would be found in a square quantum well with similar linewidth. A near-resonant n/sub 2/ of 8.4/spl times/10/sup -7/ cm/sup 2//W at 3.1 /spl mu/m is calculated. The off-resonant n/sub 2/ is also calculated and shown to be attractive at wavelengths as short as 1.55 /spl mu/m.
Thinking and Practice on the Construction of Innovative Practice Course (2021)

Innovative practice courses are the basis for the implementation of innovation credit and play an important role in cultivating college students' innovative ability. Innovative practice courses should be based on guiding innovation. The construction of courses needs to be carried out comprehensively in the aspects of course content, class organization, and course evaluation methods. Based on the construction of innovative practice courses "mobile development technology practice", the attempt in the construction of innovative practice courses is introduced. There are still some problems in the development of innovative practice courses in the course selection, evaluation, time setting, and the improvement of innovation, which is needed to be resolved in many ways. In response to the problems, some thoughts and suggestions is given in the paper.
X-Ray Computed Tomography Applied as a Comprehensive Technique for Material Analysis and Dimensional Measurement of Metallic Parts (2014)

X-ray computed tomography, first conceived to image internal structures of the human body, has become an important metrology technique for material quality control and dimensional quality control. As a material quality control tool, discontinuities, cracks and voids can be detected without physically destroying or damage the sample under analysis. As a dimensional metrology technique, the complete examination in a non-destructive manner of inner and outer geometries of parts and components has become possible. In this paper, material investigation of connecting rods manufactured through both casting and forging processes and dimensional evaluation of intricate geometries found on connecting rods are described and discussed from the metrology point of view.
Characterization of a Novel Chemotactic Factor for Neutrophils in the Bronchial Secretions of Patients with Cystic Fibrosis (2002)

Chronic airway inflammation is a hallmark of cystic fibrosis (CF). Biological products with chemotactic activity are essential for neutrophil recruitment to sites of inflammation. The presence of a factor with chemotactic activity higher than that of interleukin (IL)-8 in the bronchial secretions of patients with CF has recently been reported. This article reports that the chemotactic activity of this factor remained unaffected by a variety of physical treatments and could be distinguished from those of IL-8, formylmethionylleucylphenylalanine, leukotreine B4, and platelet-activating factor. The factor induced chemotaxis and chemokinesis locomotion of neutrophils, and its chemotactic activity was sensitive to pertussis toxin and thapsigargin. Semipurified preparation of the chemotactic factor increased transiently intracellular Ca(2+) concentration but failed to stimulate the release of neutrophil primary granules and the production of superoxide, suggesting that the semipurified chemotactic factor is a Ca(2+)-dependent chemoattractant of neutrophils, acting via pertussin toxin-sensitive G protein-coupled surface receptors, that directs neutrophil movement toward the airway epithelium.
Inhalation System for Pulmonary Aerosol Drug Delivery in Rodents Using Large Porous Particles (2000)

The pulmonary system is an attractive noninvasive route for effective delivery of drugs for both local and systemic therapies. In this study, an inhalation system was developed to effectively aerosolize and deliver small amounts (typically 1-5 mg) of dry powder polymeric and nonpolymeric particles to the lungs of anesthetized rodents over a very short period of time using a ventilator while the animals breathed spontaneously. The new aerosols were designed for size, porosity, and lightness and were characterized by particles of low mass density (rho less than or equal to 0.1 g/cm3) and large size (d approximately 10 mum). The inhalation system was tested in vivo to determine 1) whether the relatively efficient in vitro aerosolization of these large porous particles translated into a substantial respirable fraction in vivo; 2) whether the bioavailability of an encapsulated drug for systemic therapy could be increased and the drug release in the systemic circulation could be sustained; and 3) whether an encapsulated drug for local asthma therapy could sustain bronchodilation over a prolonged time period. Unlike the conventional (small non-porous) particles which deposit primarily in the tubing and trachea (80% of all particle mass delivered), 55% of the large porous particle mass deposited in the deep lung. The total systemic bioavailabilities of inhaled porous estradiol, insulin, and testosterone relative to subcutaneous injections were 86%, 88%, and 177%, respectively. The inhaled dry powder albuterol sulfate aerosol was capable of preventing sustained bronchoconstriction (in response to carbachol challenge) for approximately one day. Our data indicate that the experimental inhalation system we developed will be an excellent device for further testing of new therapeutics available in particulate form.
Evaluation of the Compatibility and Physical Properties of Silicone Elastomer Containing Hydrophilic and/or Hydrophobic Additives (1987)

Hydrophilic additives viz water, PEG 200, 400 and 600 have been successfully incorporated into medical grade silicone elastomer via the pre-formation of a water-in-oil emulsion. The formulation, including an emulsifier, has been optimised and hydrophilic particles of low, narrow size distribution incorporated into the silicone matrix. These additions were shown to have insignificant effect on the curing characteristics of the polymer. Various amounts of PEG were loaded into the elastomer and physical properties measured. There was no significant variation in these properties for the PEG MWt range chosen. However, at high loadings (greater than 20 wt %) these properties are significantly reduced. The use of such a system for incorporating, and subsequently controllably releasing hydrophilic drugs, is discussed.
Extrusion von technischen ZSM-5-Kontakten und ihre Anwendung im MTO-Prozess (2009)

In dieser Arbeit wurden technische Zeolithkatalysatoren (ZSM-5 + Binder) mittels Extrusion hergestellt und im Festbett-MTO-Prozess (Methanol-to-Olefins) getestet. Das Ziel war die Optimierung der Reaktionsbedingungen und des Katalysators, um möglichst hohe Selektivitäten zu Ethen und Propen sowie verbesserte Katalysatorstandzeiten zu erreichen.
Predictors of Placement Recommendations for Children with Behavioral or Emotional Disorders (2002)

This study investigated the relationship among teacher efficacy, child socioeconomic status (SES), child ethnicity, and educational placement recommendations concerning children with behavioral or emotional disorders (E/BD). For the study, 350 special education teachers were randomly selected from 10 school districts in the Denver metropolitan area. Participants completed the Expanded Teacher Efficacy Scale to measure Classroom Management/Discipline, External Influences, and Personal Teaching Efficacy. Participants also completed the Educational Placement Vignette. After reading the descriptive case study of a fourth grade boy identified as having E/BD, special educators indicated the placement option they would recommend for the student. Vignettes were identical except for variations regarding the child's SES and ethnicity. Results suggest that Classroom Management/Discipline, External Influences, and child SES are significant predictors of special education teachers’ placement recommendations. Knowledge acquired through this investigation provides a foundation for a theory concerning how educational placement decisions are determined. Recommendations are made for using the knowledge to reduce placement rates in restrictive environments, and suggestions are provided to advance the theory regarding how placement decisions are made.
Glutathione<i>S</i>-Transferase Polymorphisms and Outcome of Chemotherapy in Childhood Acute Myeloid Leukemia (2001)

Children who lacked GSTT1 had greater toxicity and reduced survival after chemotherapy for AML compared with children with at least one GSTT1 allele. If confirmed in further studies, GSTT1 genotype might be useful in selecting appropriate chemotherapy regimens for children with AML.
Extraction of Methane from Methane Hydrate Using Lasers (2003)

A new laser tool for the extraction of methane from methane hydrates is proposed, and its superiority over other methods is discussed. The type of laser suitable for the extraction is also discussed, and the chemically pumped oxygen-iodine energy transfer laser (COIL) is found to be the most suitable candidate.
Fast features for time constrained object detection (2009)

This paper concerns itself with the development and design of fast features suitable for time constrained object detection. Primarily we consider three aspects of feature design; the form of the precomputed datatype (e.g. the integral image), the form of the features themselves (i.e. the measurements made of an image), and the models/weak- learners used to construct weak classifiers (class, non-class statistics). The paper is laid out as a guide to feature designers, demonstrating how appropriate choices in combining the above three characteristics can prevent bottlenecks in the run-time evaluation of classifiers. This leads to reductions in the computational time of the features themselves and, by providing more discriminant features, reductions in the time taken to reach specific classification error rates. Results are compared using variants of the well known Haar-like feature types, Rectangular Histogram of Oriented Gradient (RHOG) features and a special set of Histogram of Oriented Gradient features which are highly optimized for speed. Experimental results suggest the adoption of this set of features for time-critical applications. Time-constrained comparisons are presented using pedestrian and road sign detection problems. Comparison results are presented on time-error plots, which are a replacement of the traditional ROC performance curves.
Executive Officer for the AES (2011)

The AES is pleased to announce the appointment of its inaugural Executive Officer, Maria Eliadis (pictured), who commenced in this role with the AES on 4 July 2011. She has a fractional 0.6 appointment and will be assisted by the newly appointed Administration and Membership Manager, Anita Newbery. Maria presents us with a wonderful blend of competencies having been a member of the AES, an evaluation consultant and a senior manager for professional membership and not-for-profit organisations. Maria is based in Melbourne and will be establishing a Melbourne-based office for the AES. The AES is very pleased to have engaged Maria and looks forward to working with her to achieve the objectives outlined in the AES Strategic Plan (2010-2020).
Potential Anticancer Agents.<sup>1</sup> LXXVII. Synthesis of Nucleosides of Purine-6-thiol (6-Mercaptopurine) Containing “Fraudulent” Sugars (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential Anticancer Agents.1 LXXVII. Synthesis of Nucleosides of Purine-6-thiol (6-Mercaptopurine) Containing "Fraudulent" SugarsElmer J. Reist, Allen Benitez, William W. Lee, B. R. Baker, and Leon GoodmanCite this: J. Org. Chem. 1962, 27, 9, 3279–3283Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://pubs.acs.org/doi/10.1021/jo01056a072https://doi.org/10.1021/jo01056a072research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solubilization, solutions, and processing of aromatic heterocyclic rigid rod polymers in aprotic organic solvents: poly(p-phenylene-2,6-benzobisthiazolediyl) (PBT) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubilization, solutions, and processing of aromatic heterocyclic rigid rod polymers in aprotic organic solvents: poly(p-phenylene-2,6-benzobisthiazolediyl) (PBT)Samson A. Jenekhe, Paul O. Johnson, and Ashwini K. AgrawalCite this: Macromolecules 1989, 22, 8, 3216–3222Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ma00198a005https://doi.org/10.1021/ma00198a005research-articleACS PublicationsRequest reuse permissionsArticle Views526Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Emulsion Polymerization by Continuous Feed of Reactants (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEmulsion Polymerization by Continuous Feed of ReactantsPaul Fram, Graham T. Stewart, and Andrew J. SzlachtunCite this: Ind. Eng. Chem. 1955, 47, 5, 1000–1005Publication Date (Print):May 1, 1955Publication History Published online1 May 2002Published inissue 1 May 1955https://pubs.acs.org/doi/10.1021/ie50545a036https://doi.org/10.1021/ie50545a036research-articleACS PublicationsRequest reuse permissionsArticle Views173Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Green Epoxy Resin System Based on Lignin and Tung Oil and Its Application in Epoxy Asphalt (2016)

In this work, lignin-based epoxy was synthesized by reacting epichlorohydrin (ECH) and partially depolymerized lignin (PDL) and then used for modification of asphalt. The Diels–Alder adduct of methyl esters of eleostearic acid and maleic anhydride (ME-MA) was synthesized and used as a biobased curing agent. The structure of PDL-epoxy was characterized by FTIR and 31P NMR. Nonisothermal curing kinetics and thermal properties of the cured epoxy resins were studied by differential scanning analysis, dynamic mechanical analysis, and thermogravimetric analysis, respectively. Curing behaviors of PDL-epoxy and a commercial epoxy DER332 were compared. Effects of epoxy content on rheological properties of the modified asphalt binder were studied using a parallel plate rheometer. Results show that the elastic behavior of asphalt binder at elevated temperatures was improved with increase in epoxy content.
SeamlessDesign for 3D object creation (2000)

The paper discusses SeamlessDesign, a novel collaborative workspace for rapid creation of 3D objects with constraints. Its seamless design supports both shape and behavioral designs of 3D objects in a unified and intuitive manner. Virtual and augmented setups support both multiple perspectives for parallel activity and face-to-face interaction for rich awareness.