gebhart/patrepeval huggingface dataset:
Molecular detection of tumor contamination in peripheral blood stem cell harvests. (1994)

A total of 96 peripheral blood stem cell harvests (PBSCH) were collected following standard chemotherapy from 27 patients with leukemia, lymphoma, and myeloma. Tumor molecular markers were analyzed in diagnostic samples by Southern blot [immunoglobulin heavy chain (IgHJ), T cell receptor (TcR) delta chain, TcR beta chain] and polymerase chain reaction (PCR) amplification [IgH, TcR delta, t(14;18) translocation] and found in 11 of 22 and 13 of 27 patients, respectively. At a sensitivity of 2 to 5%, Southern blot analysis failed to detect tumor in PBSCH. Using PCR with sensitivities of 10(-4) (IgH, TcR delta) to 10(-6) [t(14;18)] tumor was present in 34 PBSCH collected from five patients with acute lymphoblastic leukemia and two with lymphoma. In these patients, PBSCH collected after successive courses of chemotherapy remained consistently positive. However, no tumor was detected in 28 PBSCH from five patients with lymphoma and one with myeloma. Of eight patients who had bone marrow examined (six concurrently) within 3 weeks of PBSCH, one had tumor in the PBSCH but not in the bone marrow, and three had tumor in the bone marrow but not in the PBSCH, indicating a possible advantage in using PBSC for autologous transplantation in these patients. Although PBSC are an alternative source of stem cells to bone marrow and are considered to have a lower incidence of tumor contamination, the majority of PBSC in this study were positive by PCR analysis. PCR analysis was unable to determine if a positive result represents clonogenic cells capable of initiating relapse following transplant.
Effects of Salience Are Short-Lived (2008)

A salient event in the visual field tends to attract attention and the eyes. To account for the effects of salience on visual selection, models generally assume that the human visual system continuously holds information concerning the relative salience of objects in the visual field. Here we show that salience in fact drives vision only during the short time interval immediately following the onset of a visual scene. In a saccadic target-selection task, human performance in making an eye movement to the most salient element in a display was accurate when response latencies were short, but was at chance when response latencies were long. In a manual discrimination task, performance in making a judgment of salience was more accurate with brief than with long display durations. These results suggest that salience is represented in the visual system only briefly after a visual image enters the brain.
Narcissism, Self-Esteem, and the Positivity of Self-Views: Two Portraits of Self-Love (2002)

The authors hypothesized that both narcissism and high self-esteem are associated with positive self-views but each is associated with positivity in different domains of the self. Narcissists perceive themselves as better than average on traits reflecting an agentic orientation (e.g., intellectual skills, extraversion) but not on those reflecting a communal orientation (e.g., agreeableness, morality). In contrast, high-self-esteem individuals perceive themselves as better than average both on agentic and communal traits. Three studies confirmed the hypothesis. In Study 1, narcissists rated themselves as extraverted and open to experience but not as more agreeable or emotionally stable. High-self-esteem individuals rated themselves highly on all of these traits except openness. In Study 2, narcissists (but not high-self-esteem individuals) rated themselves as better than their romantic partners. In Study 3, narcissists rated themselves as more intelligent, but not more moral, than the average person. In contrast, high-self-esteem individuals viewed themselves as more moral and more intelligent.
Cell-Based IL-15:IL-15Rα Secreting Vaccine as an Effective Therapy for CT26 Colon Cancer in Mice. (2019)

Interleukin (IL)-15 is an essential immune-modulator with high potential for use in cancer treatment. Natural IL-15 has a low biological potency because of its short half-life and difficulties in mass-production. IL-15Rα, a member of the IL-15 receptor complex, is famous for its high affinity to IL-15 and its ability to lengthen the half-life of IL-15. We have double-transfected IL-15 and its truncated receptor IL-15Rα into CT26 colon cancer cells to target them for intracellular assembly. The secreted IL-15:IL-15Rα complexes were confirmed in ELISA and Co-IP experiments. IL-15:IL15Rα secreting clones showed a higher anti-tumor effect than IL-15 secreting clones. Furthermore, we also evaluated the vaccine and therapeutic efficacy of the whole cancercell vaccine using mitomycin C (MMC)-treated IL-15:IL15Rα secreting CT26 clones. Three sets of experiments were evaluated; (1) therapeutics, (2) vaccination, and (3) longterm protection. Wild-type CT26-bearing mice treated with a single dose of MMC-inactivated secreted IL-15:IL-15Rα clones prolonged survival compared to the control group. Survival of MMC-inactivated IL-15:IL-15Rα clone-vaccinated mice (without any further adjuvant) exceeded up to 100%. This protection effect even lasted for at least three months after the immunization. Secreted IL-15:IL-15Rα clones challenging trigger anti-tumor response via CD4<sup>+</sup> T, CD8<sup>+</sup> T, and natural killer (NK) cell-dependent cytotoxicity. Our result suggested that cell-based vaccine secreting IL-15:IL-15Rα, may offer the new tools for immunotherapy to treat cancer.
Communication at Low Data Rates--Oscillator Models and Corresponding Optimal Receivers (1968)

For virtually any model of an unstable oscillator, at low signal-to-noise ratios, the maximum-likelihood ratio receiver is asymptotically quadratic. A quadratic receiver roughly corresponds to a weighted spectral analysis of the received signal. Two major models of unstable oscillators which seem reasonable for low data rate communication using orthogonal signals are considered. The first assumes that the signal is a stationary narrow-band Gaussian process. The second assumes that the oscillator phase is a random process. Optimal receivers are obtained for the first model and several examples of the second. These receivers are all noted for their inordinate degree of nonlinearity and complexity.
Systematic large-scale meta-analysis identifies a panel of two mRNAs as blood biomarkers for colorectal cancer detection (2016)

Colorectal cancer (CRC) is the third most common cancer in the world. A significant survival rate is achieved if it is detected at an early stage. A whole blood screening test, without any attempt to isolate blood fractions, could be an important tool to improve early detection of colorectal cancer. We searched for candidate markers with a novel approach based on the Transcriptome Mapper (TRAM), aimed at identifying specific RNAs with the highest differential expression ratio between colorectal cancer tissue and normal blood samples. This tool permits a large-scale systematic meta-analysis of all available data obtained by microarray experiments. The targeting of RNA took into consideration that tumour phenotypic variation is associated with changes in the mRNA levels of genes regulating or affecting this variation.A real time quantitative reverse transcription polymerase chain reaction (qRT- PCR) was applied to the validation of candidate markers in the blood of 67 patients and 67 healthy controls. The expression of genes: TSPAN8, LGALS4, COL1A2 and CEACAM6 resulted as being statistically different.In particular ROC curves attested for TSPAN8 an AUC of 0.751 with a sensitivity of 83.6% and a specificity of 58.2% at a cut off of 10.85, while the panel of the two best genes showed an AUC of 0.861 and a sensitivity of 92.5% with a specificity of 67.2%.Our preliminary study on a total of 134 subjects showed promising results for a blood screening test to be validated in a larger cohort with the staging stratification and in patients with other gastrointestinal diseases.
증례 : 종격동내 췌장가성낭종 1 예 (1990)

Pancreatic pseudocyst represents one of the most common complications of pancreatitis. Pancreatic pseudocysts are usually found in the abdomen, but rarely in the mediastinum. We experienced one case of mediastinal extended pancreatic pseudocyst. A 48-yearold male was admitted to our hospital for a one week history of left lower abdominal pain and dyspnea. His past history was onc. of a heavy alcohol drinker. One year before admission, he experienced an episode of abdominal cramping pain, which suggested on acute pancreatitis attack. Chest roentgenograms frequently demonstrate a posterior mediastinal mass, and esophagograms show esophageal displacement. However, he diagnosis in this case was confirmed by computerized axial tomography of the chest and abdomen. External drainage of the pancreatic pseudocyst was performed. On the 47th admission day, the patient was discharged in general good health and relief of all symptoms.
<i>Xwnt-8</i>, a <i>Xenopus Wnt</i>-1/<i>int</i>-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis (1991)

In amphibian embryos, formation of the basic body plan depends on positional differences in the mesoderm. Although peptide growth factors involved in mesoderm induction have tentatively been identified, additional signals are required to generate pattern in this tissue. We have isolated a Xenopus cDNA for a Wnt-1 related gene, designated Xwnt-8, which is activated in response to mesoderm-inducing growth factors. Xwnt-8 transcripts are transiently expressed, being most abundant during gastrulation at which time expression is confined primarily to ventral mesodermal cells. Embryos dorsoanteriorized by exposure to lithium exhibit greatly reduced levels of Xwnt-8 mRNA, supporting a correlation between Xwnt-8 expression and a ventral mesodermal cell fate. Surprisingly, ectopic expression of Xwnt-8 in embryos causes a dorsoanterior-enhanced phenotype. These findings suggest that Xwnt-8 may be a secondary signalling agent which is produced in response to mesoderm-inducing factors and is involved in the early steps of mesodermal patterning.
A Photochemical One-Pot Three-Component Synthesis of Tetrasubstituted Imidazoles (2014)

Tetrasubstituted imidazoles can be formed in a photochemical one-pot synthesis from aldehydes, α-aminonitriles, and isoxazoles. Condensation of the first two components produces α-(alkylideneamino)nitriles which react under basic conditions with the acylazirines formed in situ by photochemical ring transformation of the isoxazole component. This process includes an unusual cleavage of the C(2)-C(3) bond of the acylazirine. The reaction mechanism was studied by DFT calculations.
CDMA system design through asymptotic analysis (2003)

An asymptotic analysis tool, based on the results of Tse and Hanly (see IEEE Trans. Inform. Theory, vol.45, no.2, p.641-57, 1999) and allowing the analysis and design of CDMA systems with limited computer simulation, is described. As an example of application, some aspects of system design for a UMTS personal-communication satellite system are presented. Specifically, the tradeoffs involved in the allocation of available bandwidth between spreading and coding, the selection of modulation schemes, and the selection of multi-rate formats for the uplink channel are considered.
Reduced Graphene Oxide Electrodes for Large Area Organic Electronics (2011)

Interlayer lithography is used to pattern highly conductive, solution-processed, reduced graphene oxide source and drain electrodes down to 10 μm gaps. These patterned electrodes allow for the fabrication of high-performance organic thin-film transistors and complementary circuits. The method offers a viable route towards organic electronics fabricated entirely by solution processing.
The influence of the phonological neighborhood clustering coefficient on spoken word recognition. (2009)

Clustering coefficient-a measure derived from the new science of networks-refers to the proportion of phonological neighbors of a target word that are also neighbors of each other. Consider the words bat, hat, and can, all of which are neighbors of the word cat; the words bat and hat are also neighbors of each other. In a perceptual identification task, words with a low clustering coefficient (i.e., few neighbors are neighbors of each other) were more accurately identified than words with a high clustering coefficient (i.e., many neighbors are neighbors of each other). In a lexical decision task, words with a low clustering coefficient were responded to more quickly than words with a high clustering coefficient. These findings suggest that the structure of the lexicon (i.e., the similarity relationships among neighbors of the target word measured by clustering coefficient) influences lexical access in spoken word recognition. Simulations of the TRACE and Shortlist models of spoken word recognition failed to account for the present findings. A framework for a new model of spoken word recognition is proposed.
The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal (2014)

Despite their widespread use, long-acting injectable (LAI) antipsychotics (APs) are often regarded with some negativity because of the assumption of punishment, control and insufficient evolution towards psychosocial development of patients. However, LAI APs have proved effective in schizophrenia and other severe psychotic disorders because they assure stable blood levels, leading to a reduction of the risk of relapse. Therapeutic opportunities have also arisen after introduction of newer, second-generation LAI APs in recent years. Newer LAI APs are more readily dosed optimally, may be better tolerated and are better suited to integrated rehabilitation programmes. This review outlines the older and newer LAI APs available for the treatment of schizophrenia, with considerations of past and present pharmacological and therapeutic issues. Traditional, evidence-based approaches to systematic reviews and randomized clinical trials are of limited utility in this area so this paper's blending of experimental trials with observational research is particularly appropriate and effective.
THE INFLUENCE OF MULTIPLE FACTORS ON GALL BLADDER PRESSURE AFTER AURICULAR POINT STIMULATION (1993)

The study has explored 11 correlative variables which might affect the gallblad-der pressure GBP of patients with gall stone after auricular electrical stimulation by means of multiplestepwise regression. It was found that the size of gallbladder stone (X9), cholecystolithiasis (X4),sex (X1), and the baseline of GBP (X10) could affect the GBP change range (Y1) depressingly orreinforcingly. Also the baseline of GBP (Y1) could be affected by the variables X1 (sex), X2 (age),and X6 (long diameter of the gallbladder, LDGB), etc.. The result shows that the change in GBPafter auricular electrical stimulation is comprehensively influenced by multiple factors. And it providessome useful information for predicting the curative effect of auricular therapy on gallbladder stone inclinic.
Remote, brain region–specific control of choice behavior with ultrasonic waves (2020)

The ability to modulate neural activity in specific brain circuits remotely and systematically could revolutionize studies of brain function and treatments of brain disorders. Sound waves of high frequencies (ultrasound) have shown promise in this respect, combining the ability to modulate neuronal activity with sharp spatial focus. Here, we show that the approach can have potent effects on choice behavior. Brief, low-intensity ultrasound pulses delivered noninvasively into specific brain regions of macaque monkeys influenced their decisions regarding which target to choose. The effects were substantial, leading to around a 2:1 bias in choices compared to the default balanced proportion. The effect presence and polarity was controlled by the specific target region. These results represent a critical step towards the ability to influence choice behavior noninvasively, enabling systematic investigations and treatments of brain circuits underlying disorders of choice.
The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population‐based study in a Western European country (2008)

The findings support previous epidemiological estimates of the prevalence of epilepsy in developed countries. For approximately one patient in eight, epilepsy was not adequately controlled.
Has the Quick or the Owren prothrombin time method the advantage in harmonization for the International Normalized Ratio system? (2002)

Prothrombin time (PT) is the most commonly used coagulation test in health care. We sought here to compare two major PT methods (Quick and Owren) for harmonization of International Normalized Ratio (INR) results. We measured PT with an ACL 7000 analyser. We used three Owren and three Quick reagents for PT, and estimated the International Sensitivity Index (ISI) for each reagent using two local and two manufactured ISI calibrator sets. The coagulation time was measured using five different normal plasmas to assess variation for every reagent and both methods. We studied the analytical bias for every reagent and both methods at INR = 1.0 and INR = 2.5. The mean percentage coefficient of variation of the Owren reagent ISI was 2.40% and that of the Quick reagent ISI was 12.85%. The mean percentage coefficient of variation of normal plasma seconds for the Owren method was 2.54% and that for Quick was 4.02%. The absolute error at INR = 1.0 and INR = 2.5 was 0.00 and 0.04 INR for Owren, and 0.01 and 0.16 INR for Quick. The Owren PT method has the advantage over the Quick PT method in ISI calibration, normal plasma variation, within-run analytical variation and absolute error at INR = 2.5. The INR system is more demanding on analytical quality than earlier units (Ratio,%). The data would indicate that the Owren PT method has advantages over the Quick PT method in harmonization of the INR system.
The progress and prospects of non-fullerene acceptors in ternary blend organic solar cells (2018)

This review summarizes the advantages of non-fullerene acceptors and their applications in ternary blend organic solar cells.
Inhibition of Retinal Detachment-Induced Apoptosis in Photoreceptors by a Small Peptide Inhibitor of the Fas Receptor (2010)

Purpose. To test the effect of a small peptide inhibitor (Met12) of the Fas receptor on the activation of extrinsic and intrinsic apoptosis pathways after retinal detachment. Methods. Retinal-RPE separation was created in Brown Norway rats by subretinal injection of 1% hyaluronic acid. Met12, derived from the Fas-binding extracellular domain of the oncoprotein Met, was injected into the subretinal space at the time of separation. A mutant peptide and vehicle administered in a similar fashion acted as inactive controls. The extrinsic apoptotic pathway was induced in 661W cells using a Fas-activating antibody in the presence or absence of Met12. Caspase 3, caspase 8, and caspase 9 activities were measured with calorimetric and luminescent assays in retinal extracts and cell lysates. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) was performed in retinal sections 3 days after separation. Histology was performed in retinal sections 2 months after retinal detachment. Results. Met12 inhibited Fas-induced caspase 8 activation in 661W cells. Similarly, administration of Met12 into the subretinal space inhibited the activation of caspase 3, caspase 8, and caspase 9 after retinal detachment. This corresponded to a decreased level of TUNEL-positive staining of photoreceptors after retinal-RPE separation in animals that received Met12, but not inactive mutant, peptide treatment. After 2 months, the outer nuclear layer was significantly thicker, and the photoreceptor count was higher in animals treated with subretinal Met12. Conclusions. The small peptide Met12 may serve as a photoreceptor-protective agent in the setting of retinal-RPE separation.
Village-level Behavior Under Conditions of Chronic Conflict (2012)

Drawing on a panel study of households established in 2002 and a revisit in 2008–2010 to a subsample, this paper explores the livelihood pathways of 24 households in 3 villages in Badakhshan in northeastern Afghanistan. It finds that most households were worse off than they were in 2001, although they experienced a brief period of relative prosperity based on the 1 market choice available, opium poppy. The paper draws attention to the corporate nature of villages and their variable capacity to support the provision of village-level public goods. This variability is influenced in part by the relative richness of the resource base of the village and the related degree of social differentiation. Where land inequalities are high and the elite are economically secure, they have few incentives to widen provision of public goods and can be immune from social sanctions. Where the elite are economically insecure, they are likely to have a shared interest in supporting village solidarity and a moral economy and may promote the provision of public goods. External interventions focusing on village governance need to pay much greater attention to village preconditions given the extent to which the effects of such interventions are often subject to the behavior of the elite and preexisting customary structures.
Gating Properties of Na<sub>v</sub>1.7 and Na<sub>v</sub>1.8 Peripheral Nerve Sodium Channels (2001)

Several distinct components of voltage-gated sodium current have been recorded from native dorsal root ganglion (DRG) neurons that display differences in gating and pharmacology. This study compares the electrophysiological properties of two peripheral nerve sodium channels that are expressed selectively in DRG neurons (Na(v)1.7 and Na(v)1.8). Recombinant Na(v)1.7 and Na(v)1.8 sodium channels were coexpressed with the auxiliary beta(1) subunit in Xenopus oocytes. In this system coexpression of the beta(1) subunit with Na(v)1.7 and Na(v)1.8 channels results in more rapid inactivation, a shift in midpoints of steady-state activation and inactivation to more hyperpolarizing potentials, and an acceleration of recovery from inactivation. The coinjection of beta(1) subunit also significantly increases the expression of Na(v)1.8 by sixfold but has no effect on the expression of Na(v)1.7. In addition, a great percentage of Na(v)1.8+beta(1) channels is observed to enter rapidly into the slow inactivated states, in contrast to Nav1.7+beta(1) channels. Consequently, the rapid entry into slow inactivation is believed to cause a frequency-dependent reduction of Na(v)1.8+beta(1) channel amplitudes, seen during repetitive pulsing between 1 and 2 Hz. However, at higher frequencies (>20 Hz) Na(v)1.8+beta(1) channels reach a steady state to approximately 42% of total current. The presence of this steady-state sodium channel activity, coupled with the high activation threshold (V(0.5) = -3.3 mV) of Na(v)1.8+beta(1), could enable the nociceptive fibers to fire spontaneously after nerve injury.
The Case for Disinflation (1992)

Federal Reserve Board Governor Lawrence B. Lindsey discusses the consequences of inflation in developed economies in this speech presented to the Government Bond Club of New England on March 12, 1992.
Biochemical pulping. Part XXIII. Plant-tissue maceration caused by pectinolytic enzymes from Erwinia spp. under alkaline conditions. (1987)

Among manyproposals as to the mechanismof planttissue maceration,1} pectiolytic enzymes have been dem-