gebhart/patrepeval huggingface dataset:
Intercell Interference Cancellation for MC-CDMA Systems (2007)

This article considers the problem of intercellular interference cancellation for downlink MC-CDMA systems. Throughout this work, we mainly focus on parallel interference cancellation (PIC) techniques due to the low latency they present. After deriving a version of a classical PIC receiver, suitably tuned to take into account the intercellular interference, we propose another two different approaches in order to mitigate its effects. Finally, with several simulation results we demonstrate the significant performance improvements of the proposed schemes over a wide signal to interference ratio (SIR) area.
Ubiquinol Improves Symptoms in Children with Autism (2014)

Beneficial effect of ubiquinol in children with autism has been demonstrated for the first time. We assume that plasma concentration of CoQ10-TOTAL and lipid peroxidation could be used as relevant biomarkers of ubiquinol supportive therapy.
Fabrication of a 1.55-μm VCSEL and an InGaAsP-InP HBT from a common epitaxial structure (1999)

A common epitaxial structure is used for the fabrication of a 1.55-μm vertical-cavity surface-emitting laser and an InGaAsP-InP heterojunction bipolar transistor (HBT). By selectively applying zinc diffusion directly after growth, the doping type of the HBT cap and emitter is reversed, providing the epitaxial material used for the laser. This enables a similar process to be used for the two devices. Fabricated HBTs show a current gain of 400 at a collector current of 20 mA. Lasers are electrically pumped and operate continuous wave up to -70/spl deg/C.
Fast hazard detection in combinational circuits (2004)

In designing asynchronous circuits it is critical to ensure that cir-cuits are free of hazards in the specified set of input transitions. In this paper, two new algorithms are proposed to determine if a com-binational circuit is hazard-free without exploring all its gates, thus providing more efficient hazard detection. Experimental results in-dicate that the best new algorithm on average visits only 20.7% of the original gates, with an average runtime speedup of 1.69 and best speedup of 2.27 (for the largest example.
An emperical study of the strategic planning of information centers in Taiwan (1995)

There is little doubt that the information center (IC) as a typical organization unit is here to stay among large corporations in Taiwan. However, the challenges and opportunities created by the strategic potential of the IC has been ignored. This paper addresses the topic by presenting a survey of the emerging issues of managing information centers from the perspective of IC management. The roles of strategic planning for the IC include: the service and usage, content, and implementation. Specifically, several aspects of strategic issues related to the companywide plan, corporate resources, and human-computer interaction are also discussed, including the practices, services in various industries. Potential obstacles in their efforts to better implement end-user computing environments are also explored.
A programmable co-porcessor for MPEG-4 video (2002)

A programmable processor architecture for MPEG-4 video is proposed, that can serve as a co-processor module in MPEG-4 decoder systems. it consists of a 64-bit dual-issue VLIW macroblock engine, a separate RISC core for bitstream parsing and system processing, and an autonomous I/O processor. A separate DSP is used for MPEG audio support. The architecture is fully programmable and supports parallelism on data-, instruction- and thread-level to cope with the high flexibility and processing demands of the MPEG-4 standard. The first implementation will support realtime decoding of MPEG-4 advanced simple profile or of MPEG-4 ACE-profile (CCIR601, single-object). Future designs will add support for object-based MPEG-4 functionalities. The paper focuses on the architecture, instruction set, and performance of the macroblock engine, which operates as an autonomous co-processor and carries most of the workload in MPEG-4 video processing.. It has a RISC-based architecture with support for parallel processing of instructions and data. Special instructions are implemented with specific support for video processing.
Recent Studies in the Aging of Natural Rubber (1966)

Abstract Natural rubber, when properly compounded, produces articles having an unrivalled combination of properties such as strength, elastic modulus, and resilience. However, in common with the properties of all other polymers, these excellent qualities progressively deteriorate on contact with oxygen, especially at elevated temperatures. The increasing demand for elastomers capable of service at even higher temperatures requires more stringent efforts by research workers for the production of aging-resistant natural rubber, and, in general, two approaches are possible. On the one hand further developments may be sought in the efficiency of the protective systems used. This will necessitate a reasonable understanding of the mechanisms of antioxidant action, and recent reviews have shown the large amount of research effort being applied to this end. On the other hand, modification of the present vulcanization methods to give vulcanizates with inherently greater resistance to aging is a possibility, although progress in this direction requires a detailed knowledge of vulcanization mechanism and vulcanizate structure. The recent work of the Vulcanization Group at NRPRA has shed considerable light on both these aspects of natural rubber chemistry and improved the prospects of success in this direction. In this paper we report results of studies carried out in both the fields described above which have led to the development of technologically acceptable vulcanizates having improved aging resistance.
Reduced lecithin:retinol acyltransferase expression in human breast cancer (2006)

Retinoids, vitamin A (retinol) and related metabolites, have been shown to be important in regulating cell growth and differentiation. We have shown that expression of the enzyme lecithin:retinol acyltransferase (LRAT), which converts retinol to retinyl esters, is reduced in several human carcinomas as compared with adjacent normal tissue from the same organs. The purpose of this research was to determine if aspects of retinoid signaling are impaired in human breast cancer. We evaluated LRAT protein expression in neoplastic and adjacent, non-neoplastic glandular breast tissue specimens from human patients. We evaluated 26 specimens from patients diagnosed with breast cancer between 2003 and 2005. Representative paraffin-embedded tissue blocks from each tumor, with each containing adjacent non-neoplastic glandular breast tissue, were examined by immunohistochemistry with affinity purified antibodies to human LRAT protein. LRAT protein was prominently detected throughout the non-neoplastic glandular breast tissue in all of the specimens. Areas of ductal carcinoma in situ and well-differentiated invasive breast carcinomas showed an intensity of staining with the LRAT antibody which was similar to that of the adjacent normal tissue. Expression of LRAT protein progressively decreased with a reduction in the degree of tumor differentiation in invasive breast carcinomas. LRAT protein levels correlate better with the degree of ductal tumor differentiation than does estrogen receptor status in this study. Furthermore, normal human breast epithelium exhibits intense LRAT staining, indicating a major role for LRAT in human breast physiology.
Engineering the Synthesis of Five-Carbon Alcohols from Isopentenyl Diphosphate and Increasing its Production Using an Adaptive Control System (2012)

Concerns over the sustainability and environmental impact of current processes that rely heavily on nonrenewable petroleum feedstock have created a need for developing alternative processes. Bioprocesses that use enzymes or whole cells to transform renewable biomass feedstock into commercial products are an alternative that could be more sustainable and environmentally friendly. Here, I present three novel frameworks for designing, assembling, and optimizing biological pathways that could be utilized in bioprocesses. The first framework uses enzyme families as libraries for identifying enzymes able to catalyze novel reactions. I used the framework to assemble a synthetic biological pathway that produces 3-methyl-3-butenol, 3-methyl-2-butenol, and 3-methyl-butanol from isopentenyl diphosphate. I also developed a novel colorimetric assay using N-methylbenzothiazolinone-2-hydrazone to rapidly quantify these three five-carbon alcohols. The second framework is called feedback-regulated evolution of phenotype (FREP), and describes a system that dynamically regulates the mutation rate in the cell based on the level of a particular phenotype. I used the FREP framework to engineer increased tyrosine production in Escherichia coli. Finally, the third framework describes the construction of synthetic transcription factors using metabolic enzymes. I used the framework to assemble four different transcription factors, all of which generate a transcriptional change as a result of a change in isopentenyl diphosphate concentration. By combining the FREP and synthetic transcription factor assembly frameworks, I implemented an adaptive control system that increased isopentenyl diphosphate production in Escherichia coli.
Antibacterial resistance: Current problems and possible solutions (2005)

Antimicrobial resistance is a natural biological phenomenon of response of microbes to the selective pressure of an antimicrobial drug. Resistance may be inherent, which explains the phenomenon of opportunistic infection or acquired. Concern about the resistance increased in the late 1990's and since then, many governmental and agency reports have been published regarding the agricultural use of antibacterials, advising less use of antibacterials, appropriate choice of antibacterials and regimens, prevention of cross-infection and development of new antibacterials. The emergence of multidrug resistant strains of Gram-negative bacteria (Pseudomonas, Klebsiella, Enterobacter, Acinetobacter, Salmonella species) and Gram-positive organisms (Staphylococcus, Enterococcus, Streptococcus species) is the more worrisome in the present therapeutic scenario. Multidrug - resistant tuberculosis is another serious public health problems. Resistance to some agents can be overcome by modifying the dosage regimens (e.g., using high-dose therapy) or inhibiting the resistance mechanism (e.g., beta-lactamase inhibitors), whereas other mechanisms of resistance can only be overcome by using an agent from a different class. It is urgently required to ban the sale of antibiotics without prescription, to use antibiotics more judiciously in hospitals by intensive teaching of the principles of the use of antibiotics and to establish better control measures for nosocomial infections. Thus, it is highly recommended that practicing physicians should become aware of the magnitude of existing problem of antibacterial resistance and help in fighting this deadly threat by rational prescribing.
The role of oxygen in chemical vapor deposition nucleation barriers of triisobutylaluminum on silicon (1989)

The nucleation of chemical vapor deposition (CVD) using triisobutylaluminum (TIBA) on Si(100) surfaces is observed in situ with x-ray photoelectron spectroscopy. Oxygen from oxide on the silicon inhibits the rate of nucleation by reacting with adsorbed TIBA and forming a thin layer of oxidized organometallic. This layer blocks active adsorption sites and prevents further deposition. On a surface without oxide, the TIBA molecules decompose liberating aluminum that can migrate and nucleate into islands opening sites for further adsorption and film growth. Thus the barrier to nucleation on oxide surfaces makes selected area CVD possible with TIBA.
The 1.8 Å crystal structure of a proteinase K‐like enzyme from a psychrotroph <i>Serratia</i> species (2005)

Proteins from organisms living in extreme conditions are of particular interest because of their potential for being templates for redesign of enzymes both in biotechnological and other industries. The crystal structure of a proteinase K-like enzyme from a psychrotroph Serratia species has been solved to 1.8 A. The structure has been compared with the structures of proteinase K from Tritirachium album Limber and Vibrio sp. PA44 in order to reveal structural explanations for differences in biophysical properties. The Serratia peptidase shares around 40 and 64% identity with the Tritirachium and Vibrio peptidases, respectively. The fold of the three enzymes is essentially identical, with minor exceptions in surface loops. One calcium binding site is found in the Serratia peptidase, in contrast to the Tritirachium and Vibrio peptidases which have two and three, respectively. A disulfide bridge close to the S2 site in the Serratia and Vibrio peptidases, an extensive hydrogen bond network in a tight loop close to the substrate binding site in the Serratia peptidase and different amino acid sequences in the S4 sites are expected to cause different substrate specificity in the three enzymes. The more negative surface potential of the Serratia peptidase, along with a disulfide bridge close to the S2 binding site of a substrate, is also expected to contribute to the overall lower binding affinity observed for the Serratia peptidase. Clear electron density for a tripeptide, probably a proteolysis product, was found in the S' sites of the substrate binding cleft.
Purification and characterization of protein tyrosine phosphatase PTP‐MEG2 (2002)

PTP-MEG2 is an intracellular protein tyrosine phosphatase with a putative lipid-binding domain at the N-terminus. The present study reports expression, purification, and characterization of the full-length form of the enzyme plus a truncated form containing the catalytic domain alone. Full-length PTP-MEG2 was expressed with an adenovirus system and purified from cytosolic extracts of human 293 cells infected with the recombinant adenovirus. The purification scheme included chromatographic separation of cytosolic extracts on fast flow Q-Sepharose, heparin-agarose, l-histidyldiazobenzylphosphonic acid agarose, and hydroxylapatite. The enrichment of PTP-MEG2 from the cytosol was about 120-fold. The truncated form of PTP-MEG2 was expressed in E. coli cells as a non-fusion protein and purified by using a chromatographic procedure similar to that used for the full-length enzyme. The purified full-length and truncated enzymes showed single polypeptide bands on SDS-polyacrylamide gel electrophoresis under reducing conditions and behaved as monomers on gel exclusion chromatography. With para-nitrophenylphosphate and phosphotyrosine as substrates, both forms of the enzyme exhibited classical Michaelis-Menten kinetics. Their responses to pH, ionic strength, metal ions, and protein phosphatase inhibitors are similar to those observed with other characterized tyrosine phosphatases. Compared with full-length PTP-MEG2, the truncated DeltaPTP-MEG2 displayed significantly higher V(max) and lower K(m) values, suggesting that the N-terminal putative lipid-binding domain may have an inhibitory role. The full-length and truncated forms of PTP-MEG2 were also expressed as GST fusion proteins in E. coli cells and purified to near homogeneity through affinity columns. However, the specific phosphatase activities of the GST fusion proteins were 10-25-fold below those obtained with the correspondent non-fusion proteins.
ISRO's programmable digital waveform generator (2008)

One of the major and common requirements for all active microware sensors is generation of the transmit modulation signal-like chirp/LFM signal, MSK, etc., which can be generated by analog or digital means. With the increasing demands of side bandwidth, longer duration chirp signals in radar systems, digital signal generation, and processing has emerged as a preferred alternative. Design and development of programmable and generic digital waveform generator (DWG) system based on Xilinx Virtex XCV600 FPGA and high-speed DAC is carried out at the Space Applications Center. ISRO is to generate required transmit chirp signal of high time-bandwidth product (~ 1000) for ISO's microwave radar sensor missions. This gives a detailed description of the design requirements, implementation details, salient performance features, and test results of this programmable and generic digital waveform generator (DWG).
Comparative role of intravitreal ranibizumab versus bevacizumab in choroidal neovascular membrane in age-related macular degeneration (2011)

Ranibizumab and bevacizumab are equally safe and efficacious in treating CNVM due to AMD.
SMILES Enumeration as Data Augmentation for Neural Network Modeling of Molecules (2017)

Simplified Molecular Input Line Entry System (SMILES) is a single line text representation of a unique molecule. One molecule can however have multiple SMILES strings, which is a reason that canonical SMILES have been defined, which ensures a one to one correspondence between SMILES string and molecule. Here the fact that multiple SMILES represent the same molecule is explored as a technique for data augmentation of a molecular QSAR dataset modeled by a long short term memory (LSTM) cell based neural network. The augmented dataset was 130 times bigger than the original. The network trained with the augmented dataset shows better performance on a test set when compared to a model built with only one canonical SMILES string per molecule. The correlation coefficient R2 on the test set was improved from 0.56 to 0.66 when using SMILES enumeration, and the root mean square error (RMS) likewise fell from 0.62 to 0.55. The technique also works in the prediction phase. By taking the average per molecule of the predictions for the enumerated SMILES a further improvement to a correlation coefficient of 0.68 and a RMS of 0.52 was found.
Pharmacologic reversion of epigenetic silencing of the PRKD1promoter blocks breast tumor cell invasion and metastasis (2013)

Our data suggest that the status of epigenetic regulation of the PRKD1 promoter can provide valid information on the invasiveness of breast tumors and therefore could serve as an early diagnostic marker. Moreover, targeted upregulation of PKD1 expression may be used as a therapeutic approach to reverse the invasive phenotype of breast cancer cells.
Tissue Distribution of Mesenchymal Stem Cell Marker Stro-1 (2011)

Stro-1 is the best-known mesenchymal stem cell marker. However, despite its bone marrow origin, its localization in bone marrow has never been demonstrated. By immunofluorescence staining, we show here that ∼ 0.74% of nucleated bone marrow cells expressed Stro-1. We also found that ∼ 8.7% of CD34-expressing cells expressed Stro-1, and more than 20% of Stro-1-expressing cells did not express CD34. In adipose tissue Stro-1 expression was identified in the endothelium of arterioles and capillaries. Stro-1 was also localized in the endothelium of some but not all adipose tissue veins. Endothelial expression of Stro-1 was also identified in blood vessels in penis and in leg muscles, but not in other tested tissues. In these other tissues, Stro-1 was scantly expressed near but not in blood vessels. These variable and endothelial expression patterns of Stro-1 point to a need to re-examine published data that relied on Stro-1 as a mesenchymal stem cell marker.
Scalable coding based on adaptive subband for interlaced video sequences (2002)

Resolution scalability refers to a picture coding property where pictures at lower different resolutions can be reconstructed by decoding only the subsets of a single coded bit-stream, while the full resolution picture is reconstructed by decoding the total bit-stream. This paper presents a resolution scalable video coding scheme for interlaced video sequences. The proposed scalable coding scheme employs adaptive in-field/in-frame subband for spatial scalability, where in-field subband and in-frame subband are adaptively used for moving portions and stationary portions respectively. It also employs adaptive field/frame subsampling for temporal scalability. Experimental results have demonstrated that the proposed adaptive subband gives better picture quality especially for reconstructed lower resolution pictures compared to non adaptive subband.
Statistically based feedback control of photoresist application (2002)

The authors present a statistically based algorithm for the implementation of run-by-run feedback control on a semiconductor manufacturing process. The method is based on a multivariate cumulative-sum statistical process control procedure. This procedure monitors multiple process parameters in order to identify significant deviations from a given target. Once such a deviation is detected, the algorithm uses adaptive response surface models of the process in order to change the equipment settings. This procedure has been used to control the thickness and the photoactive compound concentration of photoresist applied an oxidized silicon wafers. In this application, feedback control is based on inexpensive thickness and reflectance measurements that can be totally automated. The experiments, conducted in the Berkeley Microfabrication Laboratory, show that this method can significantly improve the photoresist application process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A hybrid phish detection approach by identity discovery and keywords retrieval (2009)

Phishing is a significant security threat to the Internet, which causes tremendous economic loss every year. In this paper, we proposed a novel hybrid phish detection method based on information extraction (IE) and information retrieval (IR) techniques. The identity-based component of our method detects phishing webpages by directly discovering the inconsistency between their identity and the identity they are imitating. The keywords-retrieval component utilizes IR algorithms exploiting the power of search engines to identify phish. Our method requires no training data, no prior knowledge of phishing signatures and specific implementations, and thus is able to adapt quickly to constantly appearing new phishing patterns. Comprehensive experiments over a diverse spectrum of data sources with 11449 pages show that both components have a low false positive rate and the stacked approach achieves a true positive rate of 90.06% with a false positive rate of 1.95%.
A highly integrated, dual-band, multi-mode wireless LAN transceiver (2004)

A fully integrated radio transceiver chip for the 2.4 and 5 GHz WLAN standards 802.11a/b/g is presented in a 0.25 /spl mu/m 40 GHz BiCMOS technology. The chip integrates the LNAs, mixers, channel filters, PGC, synthesizers with VCOs and reference oscillator, transmitters, anti-aliasing filters and voltage regulators. The presented transceiver exceeds all IEEE requirements for the 802.11a/b/g CCK and OFDM standards. At 2.4 GHz, an operational range of -85 to +8 dBm and of -74 dBm to +4dBm have been demonstrated for the 11 Mb/s CCK and 54Mb/s OFDM modes, respectively. Furthermore a maximum EVM of -32 dB have been measured.