gebhart/patrepeval huggingface dataset:
Application of PVF<sub>2</sub>transducers as piezoelectric vibrators for marine fouling prevention (1981)

Abstract It has been found that piezoelectric PVF2 plastic films can be used to minimize marine fouling. High frequency, low intensity vibrations developed in such films discourage the growth of vegetable and animal organisms on the hulls of boats and ships.
Spin dephasing of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi mathvariant="normal">Kr</mml:mi></mml:mrow><mml:mrow><mml:mn>83</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math> (1979)

The nuclear-spin dephasing of the noble gas ${\mathrm{Kr}}^{83}$ has been observed. A nonexponential decay signal, which is a function of the experimental cell in the apparatus, has been measured. The spin decay characteristics of ${\mathrm{Kr}}^{83}$ have been explained in terms of an interaction of the nuclear quadrupole moment of ${\mathrm{Kr}}^{83}$ with the electric field gradients present at the nucleus during a collision of the Kr atom with the walls of the experimental cell. Qualitative agreement only is shown, since a complete quantitative analysis of the experiment is not available at the present time.
Truth revelation in rapid, approximately efficient combinatorial auctions (2001)

Some important classical mechanisms considered in Microeconomics and Game Theory require the solution of a dicult optimization problem. This is true of mechanisms for combinatorial auctions, which have in recent years assumed practical importance, and in particular of the gold standard for combinatorial auctions, the Generalized Vickrey Auction (GVA). Traditional analysis of these mechanisms - in particular, their truth revelation properties - assumes that the optimization problems are solved precisely. In reality, these optimization problems can usually be solved only in an approximate fashion. We investigate the impact on such mechanisms of replacing exact solutions by approximate ones. Specifically, we look at a particular greedy optimization method, which has empirically been shown to perform well. We show that the GVA payment scheme does not provide for a truth revealing mechanism. We introduce another scheme that does guarantee truthfulness for a restricted class of ...
Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. (1992)

We have investigated the composition of the earliest detectable complex (H) assembled on pre-mRNA during the in vitro splicing reaction. We show that most of the proteins in this complex correspond to heterogeneous nuclear ribonucleoproteins (hnRNP), a set of abundant RNA-binding proteins that bind nascent RNA polymerase II transcripts in vivo. Thus, these studies establish a direct parallel between the initial events of RNA processing in vitro and in vivo. In contrast to previous studies, in which total hnRNP particles were isolated from mammalian nuclei, we determined the hnRNP composition of complexes assembled on individual RNAs of defined sequence. We found that a unique combination of hnRNP proteins is associated with each RNA. Thus, our data provide direct evidence for transcript-dependent assembly of pre-mRNA in hnRNP complexes. The observation that pre-mRNA is differentially bound by hnRNP proteins prior to spliceosome assembly suggests the possibility that RNA packaging could play a central role in the mechanism of splice site selection, as well as other posttranscriptional events.
<i>Brahmi rasayana</i> Improves Learning and Memory in Mice (2006)

Cure of cognitive disorders such as amnesia, attention deficit and Alzheimer's disease is still a nightmare in the field of medicine. Nootropic agents such as piracetam, aniracetam and choline esterase inhibitors like Donepezil are being used to improve memory, mood and behavior, but the resulting side effects associated with these agents have made their use limited. The present study was undertaken to assess the potential of Brahmi rasayana (BR) as a memory enhancer. BR (100 and 200 mg kg(-1) p.o.) was administered for eight successive days to both young and aged mice. Elevated plus maze and passive-avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg kg(-1) i.p.) was used to induce amnesia in mice. The effect of BR on whole brain AChE activity was also assessed. Piracetam (200 mg kg(-1) i.p.) was used as a standard nootropic agent. BR significantly improved learning and memory in young mice and reversed the amnesia induced by both scopolamine (0.4 mg kg(-1) i.p.) and natural aging. BR significantly decreased whole brain acetyl cholinesterase activity. BR might prove to be a useful memory restorative agent in the treatment of dementia seen in elderly.
Mapping of T7 RNA polymerase active site with novel reagents – oligonucleotides with reactive dialdehyde groups (1999)

Oligonucleotides of a novel type containing 2'-O-beta-ribofuranosyl-cytidine were synthesized and further oxidized to yield T7 consensus promoters with dialdehyde groups. Both types of oligonucleotides were tested as templates, inhibitors, and affinity reagents for T7 RNA polymerase and its mutants. All oligonucleotides tested retained high affinity towards the enzyme. Wild-type T7 RNA polymerase and most of the mutants did not react irreversibly with oxidized oligonucleotides. Affinity labeling was observed only with the promoter-containing dialdehyde group in position (+2) of the coding chain and one of the mutants tested, namely Y639K. These results allowed us to propose the close proximity of residue 639 and the initiation region of the promoter within initiation complex. We suggest the oligonucleotides so modified may be of general value for the study of protein-nucleic acid interactions.
Conquering the world the War Scroll (1QM) reconsidered (2009)

Unique in its genre and content, the War Scroll (1QM) presents a vision of an impending eschatological war. Although originally interpreted as being the product of a single author from the Qumran Sect, the composition's inconsistencies quickly led to the view that it is in fact an eclectic document with an elaborate compositional history. Yet all such theories were formulated prior to the publication of War Scroll-like texts from Caves 4 and 11. A careful re-examination of the War Scroll suggests instead that what began as a primitive and cohesive composition from the Hellenistic period about a two-stage conquest of the world was eventually updated in order to fit the new historical realities faced by the sectarians under Roman rule.
Molecular cloning, encoding sequence, and expression of vaccinia virus nucleic acid-dependent nucleoside triphosphatase gene. (1986)

A rabbit poxvirus genomic library contained within the expression vector lambda gt11 was screened with polyclonal antiserum prepared against vaccinia virus nucleic acid-dependent nucleoside triphosphatase (NTPase)-I enzyme. Five positive phage clones containing from 0.72- to 2.5-kilobase-pair (kbp) inserts expressed a beta-galactosidase fusion protein that was reactive by immunoblotting with the NTPase-I antibody. Hybridization analysis allowed the location of this gene within the vaccinia HindIIID restriction fragment. From the known nucleotide sequence of the 16-kbp vaccinia HindIIID fragment, we identified a region that contains a 1896-base open reading frame coding for a 631-amino acid protein. Analysis of the complete sequence revealed a highly basic protein, with hydrophilic COOH and NH2 termini, various hydrophobic domains, and no significant homology to other known proteins. Translational studies demonstrate that NTPase-I belongs to a late class of viral genes. This protein is highly conserved among Orthopoxviruses.
Segmentation-Based Video Compression Using Texture and Motion Models (2011)

In recent years, there has been a growing interest in developing novel techniques for increasing the coding efficiency of video compression methods. One approach is to use texture and motion models of the content in a scene. Based on these models parts of the video frame are not coded or “skipped” by a classical motion compensated coder. The models are then used at the decoder to reconstruct the missing or skipped regions. In this paper, we describe several spatial-texture models for video coding. We investigate several texture features in combination with two segmentation strategies in order to detect texture regions in a video sequence. These detected areas are not encoded using motion compensated coding. The model parameters are sent to the decoder as side information. After the decoding process, frame reconstruction is done by inserting the skipped texture areas into the decoded frames. Using similar approach, we consider motion models based on human visual motion perception. We describe a motion classification model to separate foreground objects containing noticeable motion from the background. This motion model is then used in the encoder to again allow regions to be skipped and not coded using a motion compensated encoder. Our results indicate significant increase in terms of coding efficiency in comparison to the spatial texture-based methods. Finally, we discuss the effects and tradeoffs of these techniques based on perceptual experiments and show that in many cases the coding efficiency can be increased by up to 25% given a fixed perceptual quality.
Reconsidering the evaluation of addiction treatment: from retrospective follow‐up to concurrent recovery monitoring (2005)

Historically, addiction treatments have been delivered and evaluated under an acute-care format. Fixed amounts or durations of treatment have been provided and their effects evaluated 6-12 months after completion of care. The explicit expectation of treatment has been enduring reductions in substance use, improved personal health and social function, generally referred to as 'recovery'. In contrast, treatments for chronic illnesses such as diabetes, hypertension and asthma have been provided for indeterminate periods and their effects evaluated during the course of those treatments. Here the expectations are for most of the same results, but only during the course of continuing care and monitoring. The many similarities between addiction and mainstream chronic illnesses stand in contrast to the differences in the ways addiction is conceptualized, treated and evaluated. This paper builds upon established methods of during-treatment evaluation developed for the treatment of other chronic illnesses and suggests a parallel evaluation system for out-patient, continuing-care forms of addiction treatment. The suggested system retains traditional patient-level, behavioral outcome measures of recovery, but suggests that these outcomes should be collected and reported immediately and regularly by clinicians at the beginning of addiction treatment sessions, as a way of evaluating recovery progress and making decisions about continuing care. We refer to this paradigm as 'concurrent recovery monitoring' and discuss its potential for producing more timely, efficient, clinically relevant and accountable evaluations.
An architecture for privacy-enabled user profile portability on the web of data (2010)

Providing relevant recommendations requires access to user profile data. Current social networking ecosystems allow third party services to request user authorisation for accessing profile data, thus enabling cross-domain recommendation. However these ecosystems create user lock-in and social networking data silos, as the profile data is neither portable nor interoperable. We argue that innovations in reconciling heterogeneous data sources must be also be matched by innovations in architecture design and recommender methodology. We present and qualitatively evaluate an architecture for privacy-enabled user profile portability, which is based on technologies from the emerging Web of Data (FOAF, WebIDs and the Web Access Control vocabulary). The proposed architecture enables the creation of a universal "private by default" ecosystem with interoperability of user profile data. The privacy of the user is protected by allowing multiple data providers to host their part of the user profile. This provides an incentive for more users to make profile data from different domains available for recommendations.
P1‐055: E2027, A NOVEL PHOSPHODIESTERASE‐9 (PDE9) INHIBITOR IN DEVELOPMENT FOR TREATMENT OF DEMENTIA WITH LEWY BODIES (DLB), SHOWED NO CLINICALLY SIGNIFICANT DRUG INTERACTION WITH DILTIAZEM (2018)

E2027 selectively inhibits PDE9, an enzyme responsible for breakdown of cyclic guanosine monophosphate (cGMP), a secondary messenger critical for cognitive function. In vitro, E2027 is mainly metabolized by CYP3A4 and is a P-glycoprotein (Pgp) substrate. The objective of this study was to investigate drug-drug interactions (DDI) when E2027 is administered with diltiazem (a strong CYP3A and Pgp inhibitor). The effects of diltiazem on the pharmacokinetics (PK) of a single oral dose of E2027 in healthy subjects were evaluated. This was a single-center, open-label, single-sequence DDI study in healthy subjects. E2027 was administered as a single 100 mg dose on Day 1. Following a washout on Days 2–6, diltiazem ER (extended release formulation) 300 mg was administered once daily from Day 7 to Day 24. On Day 12, with diltiazem at steady state, a second single dose of E2027 100 mg was administered. Blood samples for PK analysis were collected up to 12 days after each E2027 dose. The extent of interaction was based on the ratio of the geometric means for Cmax and AUC with the respective 90% CI for these ratios. Fifteen subjects completed the study. Co-administration of E2027 and diltiazem resulted in a mean increase in E2027 AUC and Cmax of 51% and 14%, respectively, compared to E2027 alone. The t1/2 of E2027 increased by ∼8 hours compared to E2027 administered alone to 37.4 hours during co-administration with diltiazem due to reduced CL/F. The geometric mean ratios (90% CI) for Cmax and AUC were 1.14 (0.972, 1.34) and 1.51 (1.38, 1.65), respectively. There were no serious adverse events (SAEs) and no discontinuations due to AEs. No clinically significant findings for ECG parameters, lab abnormalities or vital signs were reported. Two incidences of neutropenia were considered unrelated to E2027 or diltiazem. The interaction between E2027 and diltiazem was mild as the geometric mean ratios were between 1.25 and 2.00. Based on the safety profile and the proposed dose for future clinical trials, this interaction was not considered to be clinically significant. E2027 can be co-administered with moderate to strong CYP3A inhibitors or Pgp inhibitors (e.g. diltiazem), without dose adjustment.
Bit Error Rate Estimation in UMTS in the Absence of an Amplitude Reference (2006)

The estimation of uncoded bit error rates (BERs) for received symbols in wireless communication systems is relatively straightforward when a reliable amplitude reference is available. However, estimation of uncoded BERs is also useful in the absence of any amplitude reference or error detection/correction information. In this paper we propose a family of techniques for performing such estimations, based on derived moments of the amplitudes of the received symbols. We show how simple ratios of moments can be used, enabling straightforward implementation in a mobile terminal. The described techniques find particular application in the UMTS 3rd generation mobile communications system, where they may be employed by mobile terminals to estimate the error rate of received power-control commands. Knowledge of the reliability of these power-control commands is important for the efficient operation of the UMTS uplink (from mobile to base station). The described techniques are especially useful in the implementation of the feature known as "fractional dedicated physical channel", which has recently been included in the "Release 6" evolution of the UIMTS specifications to make more efficient use of the available spreading codes for communications from base station to mobile
Aggregation Mechanisms of Cystatins: A Comparative Study of Monellin and Oryzacystatin (2010)

Identification of diseases caused by protein misfolding has increased interest in the way proteins adopt non-native conformations and form aggregates. In this study we address the question of how proteins sharing the same fold respond to destabilizing environmental conditions. We have studied the behavior of two members of the cystatin superfamily, MNEI, a single chain monellin, and oryzacystatin_I, a plant cystatin. Despite the close similarity of their three-dimensional architecture, these two proteins aggregate in a different way: MNEI gives rise to amyloid aggregation whereas oryzacystatin_I yields amorphous aggregates. Mutants of oryzacystatin_I, designed to make it more similar to MNEI, generally behave like the parent protein, but a construct devoid of the disordered N- and C-terminal sequences does show a tendency to form amyloid fibers. Our results suggest that precise sequence details may be more important than the three-dimensional architecture in determining the type of aggregate formed. Oryzacystatin_I appears to be a very promising model system for further studies of protein aggregation.
FT-Raman Spectroscopy: Development and Justification (1986)

There has long been a widespread interest in the feasibility of Fourier transform Raman spectroscopy. The well-deserved reputation of FT-IR has generated hopes for similar benefits in Raman spectroscopy, and the complementarity of IR and Raman spectroscopy has made the use of a single instrument for both spectroscopies both convenient and cost-effective.
Steroid Control of Longevity in <i>Drosophila melanogaster</i> (2003)

Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.
CGH-Explorer: a program for analysis of array-CGH data (2004)

CGH-Explorer is a program for visualization and statistical analysis of microarray-based comparative genomic hybridization (array-CGH) data. The program has preprocessing facilities, tools for graphical exploration of individual arrays or groups of arrays, and tools for statistical identification of regions of amplification and deletion.
Display Memory Access Issues and Anti-Aliasing with a Virtual Reality Graphics Controller. (1994)

An address recalculation pipeline used in conjunction with image composition enables the profitable technique of prioritized rendering to be employed in virtual reality applications. These techniques however require the use of large amounts of fast static memory. Aliasing is also introduced in the system and must be removed with special anti-aliasing hardware. The demands on the display memory are quite severe and an unusual memory architecture and addressing scheme are employed to meet those demands. This results in the required performance and excellent memory efficiency while requiring relatively few components. The system provides far better performance at a lower cost than high-end conventional graphics computer systems running virtual reality applications.
Hybrid RGSA and Support Vector Machine Framework for Three‐Dimensional Magnetic Resonance Brain Tumor Classification (2015)

A novel hybrid approach for the identification of brain regions using magnetic resonance images accountable for brain tumor is presented in this paper. Classification of medical images is substantial in both clinical and research areas. Magnetic resonance imaging (MRI) modality outperforms towards diagnosing brain abnormalities like brain tumor, multiple sclerosis, hemorrhage, and many more. The primary objective of this work is to propose a three-dimensional (3D) novel brain tumor classification model using MRI images with both micro- and macroscale textures designed to differentiate the MRI of brain under two classes of lesion, benign and malignant. The design approach was initially preprocessed using 3D Gaussian filter. Based on VOI (volume of interest) of the image, features were extracted using 3D volumetric Square Centroid Lines Gray Level Distribution Method (SCLGM) along with 3D run length and cooccurrence matrix. The optimal features are selected using the proposed refined gravitational search algorithm (RGSA). Support vector machines, over backpropagation network, and k-nearest neighbor are used to evaluate the goodness of classifier approach. The preliminary evaluation of the system is performed using 320 real-time brain MRI images. The system is trained and tested by using a leave-one-case-out method. The performance of the classifier is tested using the receiver operating characteristic curve of 0.986 (±002). The experimental results demonstrate the systematic and efficient feature extraction and feature selection algorithm to the performance of state-of-the-art feature classification methods.
Estimating isothermal life from thermogravimetric data (1962)

Abstract Equations are given for estimating equivalent isothermal life from thermogravimetric data and for estimating the apparent activation energy for volatilization even though the nature of the kinetic process is unknown. Illustrative data for polytetrafluoroethylene are presented. The importance of using sample temperatures, rather than furnace temperatures, is noted.
Cloning and expression of Acinetobacter calcoaceticus catechol 1,2-dioxygenase structural gene catA in Escherichia coli (1986)

Catechol 1,2-dioxygenase (EC 1.13.1.1), the product of the catA gene, catalyzes the first step in catechol utilization via the beta-ketoadipate pathway. Enzymes mediating subsequent steps in the pathway are encoded by the catBCDE genes which are carried on a 5-kilobase-pair (kbp) EcoRI restriction fragment isolated from Acinetobacter calcoaceticus. This DNA was used as a probe to identify Escherichia coli colonies carrying recombinant pUC19 plasmids with overlapping sequences. Repetition of the procedure yielded an A. calcoaceticus 6.7-kbp EcoRI restriction fragment which contained the catA gene and bordered the original 5-kbp EcoRI restriction fragment. When the catA-containing fragment was placed under the control of the lac promoter on pUC19 and induced with isopropylthiogalactopyranoside, catechol dioxygenase was formed in E. coli at twice the level found in fully induced cultures of A. calcoaceticus. A. calcoaceticus strains with mutations in the catA gene were transformed to wild type by DNA from lysates of E. coli strains carrying the catA gene on recombinant plasmids. Thus, A. calcoaceticus strains with a mutated gene can be used in a transformation assay to identify E. coli clones in which at least part of the wild-type gene is present but not necessarily expressed.