gebhart/patrepeval huggingface dataset:
DICB: Dynamic Intelligent Customizable Benign Pricing Strategy for Cloud Computing (2012)

As cloud services need a fair pricing for both service providers and customers. If the price is too high, the customer may not use it, if the price is too low, service providers have less incentive to develop services. This paper proposes a novel pricing framework for cloud services using game theory (Cournot Duopoly, Cartel, and Stackelberg models) and data mining techniques (clustering and classification, e.g., SVM (Support Vector Machine)) to determine optimal prices for cloud services. The framework is dynamic because the price is determined based on recent usage data and available resources, it is also intelligent as it takes into various economic models into consideration, it is benign because it considers two conflicting parties, service providers and consumers, into consideration at the same time, and it is customizable based on various pricing strategies proposed by service providers and usage patterns as exhibited by consumers. Linear regression is used in various game theory models to determine the optimal price. A global pricing union (GPU) framework is proposed to achieve the best practice of game theory models. Based on the proposed technique, this paper applies this pricing framework to a case study in cloud services, and demonstrates that the prices obtained meet the requirement of traditional supply-demand analysis. In other words, the price obtained is good enough.
5-OR: Cardioprotective Effect of Luseogliflozin in Patients with Type 2 Diabetes and Established Cardiovascular Disease (2019)

Recent published CV outcome trials have revealed that sodium-glucose cotransporter-2 inhibitors (SGLT2i) significantly reduced the combined CV endpoint and incidences of heart failure-associated hospitalizations in patients with type 2 diabetes mellitus (T2DM) and CV disease (CVD). However, detailed mechanisms of the benefits by SGLT2i still remain unknown. Especially, nobody can show the consensus opinion in the mechanistic effects of SGLT2i on the left ventricular (LV) diastolic dysfunction associated with T2DM. We focused the spectral tissue Doppler-derived E/e' ratio, which has been validated in simple and reproducible noninvasive assessment of LV diastolic pressures independent of rhythm, and evaluated whether or not the treatment of SGLT2i, luseogliflozin, used for 6 months could affect cardiac function in 25 patients with T2DM and CVD. Luseogliflozin used for 6 months significantly reduced HbA1c levels (8.2 ± 1.2% to 7.4 ± 0.6%, p &lt; 0.01) and systolic blood pressure (SBP)(125.6 ± 18.1 mmHg to 119.3 ± 16.8 mmHg, p = 0.04) compared to baseline levels. Moreover, luseogliflozin also significant reduced left atrial (LA) (42.2 ± 5.7 mm to 39.9 ± 6.8 mm, p = 0.01) and LV diameters (diastolic, 49.5 ± 6.9 mm to 47.6 ± 7.6 mm, p = 0.01; systolic, 35.8 ± 9.1 mm to 33.9 ± 9.8 mm, p &lt; 0.01). Remarkably, early annular tissue Doppler (e’) velocity and peak early diastolic velocity/basal septal diastolic velocity (E/e’) ratio were significantly improved, and these benefits were augmented in the group of e’&lt; 6.0cm/sec of baseline (e’ velocity, 4.8 ± 0.6 cm/sec to 5.8 ± 0.9 cm/sec, p &lt; 0.01; E/e’ ratio, 13.0 ± 4.9 to 10.9 ± 3.4, p = 0.03, respectively). There was a significant negative correlation between the changes in E/e’ ratio and baseline of E/e.’ These results indicated that lusegliflozin improved hemodynamics associated with LV diastolic function in the patients with T2DM and CVD, and support the cardio-protective effects of SGLT2i of T2DM with CVD. Disclosure Y. Ina: None. T. Kishi: None. N. Sekiguchi: None. N. Sakane: Board Member; Spouse/Partner; Kao Corporation.
The Realization of Large-Scale Photonic Integrated Circuits and the Associated Impact on Fiber-Optic Communication Systems (2006)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Large-scale photonic integrated circuits (LS PICs) have been extensively deployed throughout the fiber optic communication network. This paper discusses the properties of the LS PICs, the interaction between them, and what is necessary to create an optical transport system that fully utilizes the properties of the LS PIC. </para>
Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology (2010)

One of the main goals in cancer immunotherapy is the efficient activation of the host immune system against tumour cells. Dendritic cells (DCs) can induce specific anti-tumour immune responses in both experimental animal models and humans. However, most preclinical studies using small animal models show only limited correlation with studies carried out in clinical settings, whereas laboratory dogs naturally develop tumours that are biologically and histopathologically similar to their human counterparts. Here, we describe the generation and characterization of recombinant antibodies against canine DCs, isolated using the Tomlinson phage display system. We successfully isolated highly specific single-chain variable fragment (scFv) antibodies in a sequential three-step panning strategy involving depletion on canine peripheral blood mononuclear cells followed by positive selection on native canine DCs. This provides the basis for an antibody-based method for the immunological detection and manipulation of DCs and for monitoring antigen-specific immune responses.
Cone-beam pseudo-lambda tomography (2006)

In this paper, for the first time we define the concept of 3D pseudo-lambda tomography based on the 3D Calderon operator, and formulate an approximate local reconstruction algorithm for cone-beam data collected along an arbitrary scanning curve. The main idea is to rewrite the filtering operator in an exact filtered-backprojection reconstruction formula as a local projection. Simulation using the 3D differentiable Shepp–Logan phantom is performed to demonstrate the utility of this new technique.
EasyLab: Model-Based Development of Software for Mechatronic Systems (2008)

Model-based development tools are one possible solution to handle the increasing complexity of mechatronic systems. While traditional approaches often separate design of hardware and software, especially in mechatronic systems hardware/software interaction is the most critical component. Hence, both aspects must be considered in this context. The goal is a model-based development tool for software/hardware co-design including the generation of efficient code for the respective target platforms. EasyLab is a modular and easily expandable development tool especially suitable for such applications. Its objectives are to facilitate reusability and to accelerate the development process. It raises the level of abstraction and thus simplifies the development of mechatronic systems even for unexperienced users. A graphical user interface provides various modeling languages that are easy to use. By employing platform optimized generation of the code, efficiency of the resulting programs can be guaranteed, which we demonstrate on a set of experimental mechatronic systems.
Improving Freezing and Thawing Properties of Fly Ash Bricks (2005)

In 2004, the National Science Foundation (NSF) funded a Small Business Innovation Research (SBIR) Phase 1 grant to Freight Pipeline Company. The purpose of the grant is to improve the freeze/thaw properties of compacted fly ash bricks, so that such bricks will not deteriorate prematurely in cold climate, and they can be used anywhere in the United States for various commercial purposes. It has been established through previous research that by mixing Class-C fly ash with approximately 10% water, strong fly ash brick can be produced at compaction pressure of 3,000 psi, approximately. The bricks produced, upon two weeks of curing, have compressive strength exceeding that required by ASTM for ordinary bricks. The fly ash bricks also have good water absorption property and low permeability. However, they can only survive about 8 cycles of freeze/thaw, which is far short of the ASTM-Standard requirement of 50 cycles. Once this freeze/thaw property of the flyash bricks is improved sufficiently to pass the 50-cycle ASTM Standard, the brick will have an excellent future for commercial acceptance. With the NFS funding, Freight Pipeline Company tested various methods designed to improve the freeze/thaw property of the compacted fly ash bricks, including: (1) using higher compaction pressure and optimum fly-ash-to-water ratio, (2) adding a small amount of fiber to the fly ash before compaction, (3) adding some cement or lime to the fly ash before compaction, (4) using certain liquid sealants to coat the bricks, (5) using a higher compaction pressure to make stronger bricks, (6) lengthening the curing time in order to make stronger bricks, (7) use of a split mold to make better bricks, and (8) use of an air-entrainment agent to improve the freeze/thaw property of the bricks. The tests showed that some of the methods that further improve the compressive strength of the brick do not necessarily result in an improvement in the freeze/thaw property. For instance, method 3 (adding 5% Portland cement or lime), method 1 (using higher compaction pressure), and method 6 (lengthening curing), all result in stronger compressive strength of the fly ash brick, but they have no beneficial effect on enhancing the freeze/thaw property of the fly ash brick. On the other hand, methods that do not enhance the compressive strength of the fly ash brick, such as using fiber (method 2) and air entrainment (method 8), did show significant improvement of the freeze/thaw property. With all practical matters taken into account, including freeze/thaw resistance and simplicity in processing, the air entrainment method appears to be the most effective and practical. It enables the bricks to pass the 50-cycle freeze/thaw without damage. More tests are currently underway to evaluate the effectiveness of air entrainment
Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells. (1989)

Tyrosine phosphorylation of cellular proteins induced by heparin-binding growth factor 1 (HBGF-1) was studied by using the murine fibroblast cell line NIH 3T3 (clone 2.2). HBGF-1 specifically induced the rapid tyrosine phosphorylation of polypeptides of Mr 150,000, 130,000, and 90,000 that were detected with polyclonal and monoclonal antiphosphotyrosine (anti-P-Tyr) antibodies. The concentration of HBGF-1 required for half-maximal induction of tyrosine phosphorylation of the Mr-150,000 Mr-130,000, and Mr-90,000 proteins was approximately 0.2 to 0.5 ng/ml, which was consistent with the half-maximal concentration required for stimulation of DNA synthesis in NIH 3T3 cells. HBGF-1-induced tyrosine phosphorylation of the Mr-150,000 and Mr-130,000 proteins was detected within 30 s, whereas phosphorylation of the Mr-90,000 protein was not detected until 3 min after HBGF-1 stimulation. All three proteins were phosphorylated maximally after 15 to 30 min. Phosphoamino acid analysis of the Mr-150,000 and Mr-90,000 proteins confirmed the phosphorylation of these proteins on tyrosine residues. Phosphorylation of the Mr-150,000 and Mr-90,000 proteins occurred when cells were exposed to HBGF-1 at 37 degrees C but not at 4 degrees C. Exposure of cells to sodium orthovanadate, a potent P-Tyr phosphatase inhibitor, before stimulation with HBGF-1 resulted in enhanced detection of the Mr-150,000, Mr-130,000, and Mr-90,000 proteins by anti-P-Tyr antibodies. Anti-P-Tyr affinity-based chromatography was used to adsorb the HBGF-1 receptor affinity labeled with 125I-HBGF-1. The cross-linked HBGF-1 receptor-ligand complex was eluded with phenyl phosphate as two components: Mr 170,000 and 150,000. P-Tyr, but not phosphoserine or phosphothreonine, inhibited adsorption of the (125)I-HBGF-1-receptor complex to the anti-P-Tyr antibody matrix. Treatment of cells with sodium orthovanadate also enhanced recognition of the cross-linked (125)I-HBGF-1-receptor complex by the anti-P-Tyr matrix. These data suggest that (i) the (125)I-HBGF-1-receptor complex is phosphorylated on tyrosine residues and (ii) HBGF-1-induced signal transduction involves, in part, the tyrosine phosphorylation of at least three polypeptides.
ChemInform Abstract: 2‐Substituted Pi System Derivatives of Adenosine That Are Coronary Vasodilators Acting via the A<sub>2A</sub> Adenosine Receptor (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Paving the Way for Connected Cars with Adaptive AUTOSAR and AGL (2018)

Connected vehicles offer new business models and improved user experiences. Car manufacturers are aiming to equip their vehicles with software modules and to keep them up-to-date with new services. To ease the process of maintaining the vehicle functions and to offer basic software components over the vehicle's life-cycle the AUTOSAR (AUTomotive Open System ARchitecture) consortium started to standardize basic core functions for vehicle's Electronic Control Units (ECUs) as classic AUTOSAR real-time operating system (RTOS). However, the ever increasing user expectations require that software platforms follow recent developments in software architecture and the AUTOSAR consortium started with the design of an adaptive platform solution that is directed towards future developments. Adaptive AUTOSAR offers software components that will make it easier to deploy a standardized platform for connected cars. A missing component in adaptive AUTOSAR is the specification of a Graphical User Interface (GUI) that is required to design In-vehicle Infotainment (IVI) systems. Automotive Grade Linux (AGL) provides such appealing GUIs and is open source. In this paper, the new concept of adaptive AUTOSAR will be introduced and recent design architectures are outlined. Further, the combination of adaptive AUTOSAR and AGL are motivated to design a proof-of-concept (PoC) that is efficient to use for further performance evaluation of the software components of each software platform.
Proximity-based opinion retrieval (2010)

Blog post opinion retrieval aims at finding blog posts that are relevant and opinionated about a user's query. In this paper we propose a simple probabilistic model for assigning relevant opinion scores to documents. The key problem is how to capture opinion expressions in the document, that are related to the query topic. Current solutions enrich general opinion lexicons by finding query-specific opinion lexicons using pseudo-relevance feedback on external corpora or the collection itself. In this paper we use a general opinion lexicon and propose using proximity information in order to capture opinion term relatedness to the query. We propose a proximity-based opinion propagation method to calculate the opinion density at each point in a document. The opinion density at the position of a query term in the document can then be considered as the probability of opinion about the query term at that position. The effect of different kernels for capturing the proximity is also discussed. Experimental results on the BLOG06 dataset show that the proposed method provides significant improvement over standard TREC baselines and achieves a 2.5% increase in MAP over the best performing run in the TREC 2008 blog track.
Perception of asynchronous and conflicting visual and auditory speech (1996)

Previous research has shown that perceivers naturally integrate auditory and visual information in face-to-face speech perception. Two experiments were carried out to study whether integration would be disrupted by differences in the stimulus onset asynchrony (SOA), the temporal arrival of the two sources of information. Synthetic visible and natural and synthetic auditory syllables off/ba/, /va/, [symbol: see text]a/, and /da/ were used in an expanded factorial design to present all possible combinations of the auditory and visual syllables, as well as the unimodal syllables. The fuzzy logical model of perception (FLMP), which accurately describes integration, was used to measure the degree to which integration of audible and visible speech occurred. These findings provide information about the temporal window of integration and its apparent dependence on the range of speech events in the test.
Responsiveness to growth factors in aortic vascular smooth muscle cells from rats with cirrhosis (1997)

Hemodynamic changes in cirrhosis may be associated with alterations in aortic vascular smooth muscle cell (AVSMC) function. The present study compared the proliferative response to serum and growth factors in cirrhotic and control AVSMC. Serum from cirrhotic rats, cirrhotic cell lysates, and the conditioned medium of cultured cirrhotic AVSMC induced an increase in [3H]thymidine incorporation in control but not in cirrhotic AVSMC. Platelet-derived growth factor-beta (PDGF-BB) induced a greater increase in [3H]thymidine incorporation in cirrhotic than in control cells. [3H]thymidine incorporation induced by cirrhotic conditioned medium was blocked by anti-PDGF antibody. Immunoblot studies showed that the anti-PDGF antibody recognized a 30-kDa protein in the conditioned medium of cirrhotic AVSMC culture, a protein corresponding to PDGF. Binding studies of PDGF-BB indicated a twofold increase in receptor density in cirrhotic AVSMC with no alteration in affinity for PDGF-BB. We conclude that an increased responsiveness of cirrhotic AVSMC to the PDGF could contribute to alterations in AVSMC and muscle cell tone that may play a role in the hemodynamic changes in cirrhosis.
High efficiency ion beam accelerator system (1981)

An ion accelerator system that successfully combines geometrical and electrostatic focusing principles is described. This accelerator system uses thin, concave, multiple-hole, closely-spaced graphite screen and focusing grids, coupled to single slot accelerator and decelerator grids to provide high ion extraction efficiency with good focusing. Operating characteristics for this type of accelerator system and possible applications are discussed.
A simple and advanced neural circuit element by using an SOI insulated-gate pn junction device (2002)

Neural logic devices and circuits have been extensively studied, and recently, a /spl nu/MOS transistor and its logic circuits were proposed (Shibata and Ohmi, 1991). However, a /spl nu/MOS transistor which shows a neuron-like operation (sum of products) does not reflect a synaptic operation flexibly. The author has previously proposed a synaptic logic element by using an SOI insulated-gate p-n junction device called a lubistor (Omura, Appl. Phys. Lett. vol. 40, vol. 6, pp. 528-9, 1982), and recently demonstrated important functions (Omura, Ext. Abstr. of Int. Conf. on Solid State Dev. and Mat., pp. 140-1, 1997). This paper describes a new, simple, advanced neural circuit element and simulation results of circuit operations.
Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient. (1994)

Polymorphic epithelial mucin (MUC1) was detected in myeloma cells and in sera of multiple myeloma patients. HLA-unrestricted CTL that recognize tumor-associated epitopes on MUC1 has been shown to be induced from breast and pancreas cancer patients. To investigate whether such CTL can also be induced from multiple myeloma patients, an allogeneic mixed leukocyte tumor cell culture was performed. PBMCs of a multiple myeloma patient were stimulated by different allogeneic breast carcinoma and myeloma cell lines. The cultured PBMCs were proliferated and a CTL line TN was established. TN exclusively expressed TCR-alpha/beta, CD3, and CD8. TN lysed breast carcinoma and myeloma cell lines but did not lyse K562, which is sensitive to NK cells. The cytotoxicity of TN was inhibited by anti-CD3 Abs but not by anti-HLA Abs. Thus, the TCR-alpha/beta was considered to be involved in the recognition of the target cells but HLA was not. Furthermore, TN lysed transformed mouse fibroblast cells transfected with MUC1 cDNA, suggesting that this CTL line recognizes MUC1 directly. Thus, it is concluded that precursors of HLA-unrestricted and anti-MUC1 reactive CTL could exist in the peripheral blood of multiple myeloma patients and that myeloma cells can express epitopes on MUC1, which can be recognized by the CTL.
XLVIII.—αβ-Dibenzoylcinnamene and the constitution of Zinin's lepiden and its derivatives (1890)

F. R. Japp and F. Klingemann, J. Chem. Soc., Trans., 1890, 57, 662 DOI: 10.1039/CT8905700662
Securing and Hardening Red†Hat Linux (2006)

Abstract An operating system is only as secure as the way it is configured and set up by the systems administrator. An improperly configured system, no matter how secure the underlying OS, is a disaster waiting to happen. Security thus depends a lot on the foresight and strategies of the administrator.
39‐1: <i>Invited Paper:</i> Advanced Hyper‐Viewing Angle Controllable LCD (2021)

We have developed a new viewing angle controllable liquid crystal panel we called it lens type switching cell, which can effectively control the light through a special electrode design and rubbing conditions. In the structure, the design of the switching cell combined with the based panel and the backlight is called Advanced Hyper‐Viewing Angle Controllable (AH‐VAC) LCD. This panel In addition to having a good anti‐peep effect, the sharing mode can also have a good light viewing angle characteristic according to the voltage setting.
An Empirical Investigation of Randomized Defenses against Adversarial Attacks (2019)

In recent years, Deep Neural Networks (DNNs) have had a dramatic impact on a variety of problems that were long considered very difficult, e. g., image classification and automatic language translation to name just a few. The accuracy of modern DNNs in classification tasks is remarkable indeed. At the same time, attackers have devised powerful methods to construct specially-crafted malicious inputs (often referred to as adversarial examples) that can trick DNNs into mis-classifying them. What is worse is that despite the many defense mechanisms proposed to protect DNNs against adversarial attacks, attackers are often able to circumvent these defenses, rendering them useless. This state of affairs is extremely worrying, especially since machine learning systems get adopted at scale. In this paper, we propose a scientific evaluation methodology aimed at assessing the quality, efficacy, robustness and efficiency of randomized defenses to protect DNNs against adversarial examples. Using this methodology, we evaluate a variety of defense mechanisms. In addition, we also propose a defense mechanism we call Randomly Perturbed Ensemble Neural Networks (RPENNs). We provide a thorough and comprehensive evaluation of the considered defense mechanisms against a white-box attacker model, six different adversarial attack methods and using the ILSVRC2012 validation data set.
Cloud Application Architectures: Building Applications and Infrastructure in the Cloud (2009)

If you're involved in planning IT infrastructure as a network or system architect, system administrator, or developer, this book will help you adapt your skills to work with these highly scalable, highly redundant infrastructure services. Cloud Application Architectures will help you determine whether and how to put your applications into these virtualized services, with critical guidance on issues of cost, availability, performance, scaling, privacy, and security.