gebhart/patrepeval huggingface dataset:
Temperature Corrected Turbulence Model for High Temperature Jet Flow (2004)

It is well known that the two-equation turbulence models under-predict mixing in the shear layer for high temperature jet flows. These turbulence models were developed and calibrated for room temperature, low Mach number, and plane mixing layer flows. In the present study, four existing modifications to the two-equation turbulence model are implemented in PAB3D and their effect is assessed for high temperature jet flows. In addition, a new temperature gradient correction to the eddy viscosity term is tested and calibrated. The new model was found to be in the best agreement with experimental data for subsonic and supersonic jet flows at both low and high temperatures.
Ibuprofen treatment versus gradual introduction of interferon β-1b in patients with MS (1999)

Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.
On the Tribological Properties of PTFE Filled with Alumina Nanoparticles and Graphite (2007)

Methods used to reinforce self-lubricating polymers generally also cause a significant increase in coefficient of friction, so that a trade-off must be made between coefficient of friction and wear resistance. Polytetrafluoroethylene (PTFE) composites filled with alumina nanoparticles and graphite were prepared by compression molding. Friction and wear experiments were carried out in a reciprocating sliding tribotester at a reciprocating frequency of 1.0 Hz, contact pressure of 5.0 MPa and relative humidity of (75 3)%. The nanocomposites slid against a 45 carbon steel track. Results showed that PTFE + 15 wt% alumina + 5 wt% graphite composite (D) exhibited a coefficient of steady-state friction lower than PTFE + 15 wt% alumina composite (B), while wear resistance of composite D is higher than composite B, and by about 200 times higher than unfilled PTFE. This behavior originates from the effective lubrication of graphite that possesses an extremely low coefficient of friction under the high humidity condition.
Charge heterogeneity of human secretory component: immunoglobulin and lectin binding studies. (1984)

Free secretory component purified from human milk showed considerable charge heterogeneity in the pH range 4.7-6.5 when analysed by isoelectric focusing in thin layer agarose gels. Unlike rabbit secretory component, allotypic variation could not be identified by comparing samples from different individuals. Treatment with neuraminidase resulted in a basic shift of secretory component charge isomers. The charge heterogeneity appeared to be unrelated to the immunoglobulin binding property of secretory component since all charge isomers bound 125I-labelled IgM. 125I-labelled secretory component bound more strongly to purified IgM compared with polymeric IgA, and predominantly to the IgM-containing region of focused normal human serum. Lectin-secretory component interaction was demonstrated by concanavalin A and wheat germ agglutinin binding in a dot-blot nitrocellulose assay and precipitation with concanavalin A by Ouchterlony immunodiffusion. Despite the relatively high carbohydrate composition of both secretory component and the polymeric immunoglobulins, no evidence for lectin-like binding was obtained by sugar inhibition and sugar desorption studies. Similarly, desialation of secretory component did not prevent secretory component-IgM binding. These observations suggest that the charge heterogeneity and sugar composition of secretory component are unrelated to immunoglobulin binding in vitro.
A Case of Occlusion due to Acute In-stent Thrombosis after Carotid Artery Stenting (2009)

症例は75歳,男性.繰り返す一過性脳虚血発作(左上肢の脱力)の後,右中大脳動脈領域の脳梗塞を発症し,近医に入院した.右頚部内頚動脈狭窄を指摘され,血行再建を目的に当院に紹介入院した.NASCET法で50%程度の中等度狭窄であったが,術前検査でプラークのvulnerabilityを示唆する所見があり,症候性頚動脈狭窄症と判断し,局所麻酔下にcarotid artery stenting(CAS)を施行した.Distal protection下にsemi-compliant balloonにて前拡張した後,プラーク全体をカバーするようにPrecise^[○!R] stent(Cordis J&J Inc.)を留置した.留置直後の撮影にてステント内腔に一部,造影欠損部分を認め,その後の撮影でそれがさらに顕著になったため,プラーク内容のステント内腔への脱出(plaque protrusion)と判断した.バルーン拡張を追加し,ステント内に重ねてもう1本Precise^[○!R] stentを留置した.いったんは改善したが,時間経過とともに造影欠損部がステント内腔全体に広がり,ステント内血栓症をきたした.その後,数回のバルーン拡張を施行したが効果はなく,最終的に閉塞をきたした.CASにおけるステント内血栓症はまれな合併症であり,その原因や対処法について明確に言及した報告は少ない.今回,われわれは,ステント留置直後,plaque protrusionにより急速な血栓形成から閉塞をきたしたと推察される症例を経験したので,原因および対処法を中心に文献的考察を加え報告する.
Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. (1990)

Lymphocyte migration to lymphoid organs involves organ-specific homing receptors. The mouse peripheral lymph node homing receptor, defined by the MEL-14 monoclonal antibody (mAb), is a lectin-like cell surface protein, which is rapidly down-regulated upon cell activation with phorbol 12-myristate 13-acetate. We have raised mAbs against rapidly shed molecules released from the cell surface of activated human leukocytes. Five mAbs, DREG-55, -56, -110, -152, and -200, define an 80- to 85-kDa molecule involved in human lymphocyte recognition of peripheral lymph node (PLN) high endothelial venules (HEVs). The DREG-56 mAb specifically inhibits greater than 90% of binding of human lymphocytes to HEVs within frozen sections of peripheral but not mucosal lymphoid tissue. Furthermore, the gp80 antigen is expressed on lymphoid cell lines that are capable of binding to PLN HEVs. The DREG-56 mAb also inhibits lymphocyte binding of the phosphomannan monoester core from Hansenula hostii Y-2448, an activity associated with human and mouse lymphocyte recognition of PLN HEVs. Finally, all five DREG mAbs specifically stain COS cells transfected with LAM-1 cDNA, a putative human homologue of mouse MEL-14 antigen. These results demonstrate that the DREG mAbs define a human lymphocyte homing receptor for PLN HEVs and indicate that this human antigen is homologous to the MEL-14-defined murine lymphocyte homing receptor.
Lincomycin. V. Amino acid fragment (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLincomycin. V. Amino acid fragmentBarney J. Magerlein, Robert D. Birkenmeyer, Ross R. Herr, and Fred. KaganCite this: J. Am. Chem. Soc. 1967, 89, 10, 2459–2464Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/ja00986a038https://doi.org/10.1021/ja00986a038research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhibitory Effect of Tetrandrine on Lens Proteins-Induced Ocular Inflammation in Rabbits (1992)

Ocular inflammation was induced by 25 microliters of lens proteins (62.5mg/ml) injected into anterior chamber of the rabbit eye. Tetrandrine (Tet) (50mg/kg ip) and Indomethacin (Ind) (20 mg/kg ip) showed marked inhibition on this ocular inflammation. Maximum inhibition rate of Tet and Ind was 65% and 66% and their anti-inflammation action lasted 5 and 4 h, respectively. In the early phase of ocular inflammation (at 2 h) the total content of prostaglandin E(PGES) in the iris was reduced by Tet and Ind. Ind showed a greater effect than Tet on PGES. Tet also inhibited leukocyte chemotaxis significantly at late phase of inflammation. No significant effect was observed on the IOP recovery following reduction by 20% NaCl iv. Topical instillation of 50 microliters of 2% Tet did not display any inhibition of ocular inflammation. These results indicate that Tet is an effective ocular antiinflammatory agent without producing ocular hypertension. The antiinflammatory mechanism of Tet in early phase (at 2 h) was related to inhibition of PGES synthesis. The relationship between ocular anti-inflammation and calcium antagonism of Tet was discussed.
Mined-Knowledge and Decision Support Services in Electronic Health (2007)

Large organizations in various information domains are constantly facing the challenges of growing size, new business requirements, and customer demands for service agility. As an example, in the healthcare domain provision of unique electronic health record systems (EHR) for patient identification and health history, integration of regional systems into a nation-wide system, information and service sharing, and security and privacy of patient data have generated a set of new challenges. Canada Health In-foway has proposed an information infrastructure for networked healthcare systems that is based on service oriented architecture (SOA) and provides standards for sharing data and services. In this paper, we investigate the provision of mined-knowledge (results of data mining on patient data), clinical decision support systems, and network visualization and monitoring through SOA. We also address the advantages of SOA implementation using an enterprise service bus in order to accommodate these services. Such services can benefit similar domains such as banking, communications, air traffic control, and transportation.
BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2 (2006)

Inhibitor of DNA binding (Id) proteins bind to and inhibit the function of basic helix-loop-helix (bHLH) transcription factors including those that regulate pancreatic development. Moreover, bone morphogenetic proteins (BMPs) regulate the expression of Ids. We hypothesized that BMP4 and Id proteins play a role in the expansion and differentiation of epithelial progenitor cells. We demonstrate that BMP4 induces the expression of Id2 along with the expansion of AR42J pancreatic epithelial cells. Furthermore, neutralization of BMP4 significantly reduced duct epithelial cell expansion in a mouse model of islet regeneration. BMP4 stimulation promotes Id2 binding to the bHLH transcription factor NeuroD, which is required for the differentiation of pancreatic islet cells. Therefore, our results indicate that BMP4 stimulation blocks the differentiation of endocrine progenitor cells and instead promotes their expansion thereby revealing a novel paradigm of signaling explaining the balance between expansion and differentiation of pancreatic duct epithelial progenitors. Understanding the mechanisms of BMP and Id function elucidates a key step during pancreas embryogenesis, which is important knowledge for expanding pancreatic progenitors in vitro.
A SELECTIVE AND CONVENIENT OXIDATION OF SULFIDES TO SULFOXIDES WITH TRICHLOROISOCYANURIC ACID (2001)

Abstract Sulfides are readily oxidized to sulfoxides by a solution of pyridine, water, and trichloroisocyanuric acid in acetonitrile and methylene chloride. ACKNOWLEDGMENT This work was supported by The Major Laboratory of Organic Chemistry, Zhejiang University (Campus Xixi).
Estimation of acoustical room transfer functions (2002)

Presents a method to obtain room transfer functions for applications in the design of intelligent systems for video conferencing. In these applications the acoustical dynamics, for example, affects the quality of the recorded speech signal and the ability to achieve accurate source localization. The first part of the paper gives results on the identification of parameterized room transfer functions. The second part presents a method to extrapolate room transfer functions from the identified models. The extrapolation is achieved by getting a functional form of the transfer function parameters which depends on the speaker and the microphone locations.
Pharmacological treatment of alcohol intoxication, withdrawal and dependence: a critical review. (1987)

This review critically examines the literature of the past 10 years relating to the use of drugs in treating alcohol intoxication, withdrawal and dependence. Emphasis is given to those studies that have current and potential future clinical relevance. Although research regarding the pharmacological treatment of alcohol disorders still suffers from methodological flaws and lukewarm acceptance, the recognition of this area as a legitimate and fruitful field of study is increasingly apparent.
A novel edge sensor for web guiding (2006)

Existing edge sensors use the concept of blocking/unblocking for measuring web lateral position. The most commonly used sensors employ either ultrasonic or infrared signals to detect the web edge position by measuring the amount of signal attenuation due to blocking/unblocking of the signal. The main drawback of this sensing method is nonuniform signal attenuation due to web material variations and opacity. The research in this paper develops a new sensor which utilizes the phenomena of light scattering from the web edge and the directional sensitivity of optical fibers. A collimated laser beam is incident on the web edge and scattered light is collected by a linear array of fibers spatially positioned above the web edge. The theory of operation and the development of the sensor is described. Experiments are conducted with different web materials to validate the proposed sensing method. A representative sample of the results are presented and discussed.
Scaling unstructured peer-to-peer networks with multi-tier capacity-aware overlay topologies (2004)

The peer to peer (P2P) file sharing systems such as Gnutella have been widely acknowledged as the fastest growing Internet applications ever. The P2P model has many potential advantages due to the design flexibility of overlay networks and the server-less management of cooperative sharing of information and resources. However, these systems suffer from the well-known performance mismatch between the randomly constructed overlay network topology and the underlying IP layer topology for packet routing. This paper proposes to structure the P2P overlay topology using a capacity-aware multi-tier topology to better balance load at peers with heterogeneous capacities and to prevent low capacity nodes from downgrading the performance of the system. To study the benefits and cost of the multi-tier capacity aware topology with respect to basic and advanced routing protocols, we also develop a probabilistic broadening scheme for efficient routing, which further utilizes capacity-awareness to enhance the P2P routing performance of the system. We evaluate our design through simulations. The results show that our multi-tier topologies alone can provide eight to ten times improvements in the messaging cost, two to three orders of magnitude improvement in terms of load balancing characteristics, and seven to eight times lower topology construction and maintenance costs when compared to Gnutellas random power-law topology.
Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial. (1988)

Drug resistance to chemotherapy agents such as doxorubicin appears to be an important cause of therapeutic failure in cancer treatment. Based on preclinical information demonstrating that the phenothiazine calmodulin-inhibitor trifluoperazine can enhance retention and cytotoxicity of doxorubicin in resistant cells, a phase I/II trial of the combination was performed to determine the maximally tolerated dose (MTD) of trifluoperazine that could be administered with doxorubicin. Patients with intrinsic (no previous response) and acquired (previous response with relapse) doxorubicin resistance were eligible. Doxorubicin was administered as a 96-hour continuous infusion (60 mg/m2) on days 2 through 5. Trifluoperazine was administered in divided doses orally on days 1 through 6, with dose escalation from 20 to 100 mg/d. Thirty-six patients were evaluable. The MTD of trifluoperazine was 60 mg/d, with dose-limiting toxicity being extrapyramidal side effects. No alteration of doxorubicin toxicity was observed. Seven of the 36 patients responded (one complete response [CR], six partial responses [PR]), with seven of 21 patients having acquired resistance, and zero of 15 with intrinsic resistance demonstrating responses. Doxorubicin plasma levels were not affected by trifluoperazine, and the maximal trifluoperazine plasma levels achieved were 129.83 ng/mL. This trial demonstrates the combination of trifluoperazine and doxorubicin is well tolerated, and the schedule recommended for phase II trials is doxorubicin, 60 mg/m2 (continuous infusion) days 2 through 5, and trifluoperazine, 15 mg four times per day orally days 1 through 6. Continued investigation of this combination is indicated for patients with acquired doxorubicin resistance.
[Teaching roentgenology in related departments of a medical institute]. (1985)

The authors describe a continuity of study of roentgenology in the Omsk Medical Institute. The teaching process is divided into 4 stages: the initial level of knowledge to study general roentgenology (year I-III), general roentgenology (year III), applied roentgenology (clinical chairs, year IV-VI), clinical roentgenology (postdiploma training).
An offload method for traffic distribution based on service identification (2011)

Many functions for various network services (e.g. IP telephone, ISP connection and IP-VPN) are deployed on a broadband network, especially at the boundary between an access network and core network in the broadband network. The network service must be identified from each packet and the packet must be processed appropriately for that service. IP traffic in the broadband network is increasing sharply, so traffic distribution based on service identification may bottleneck when many different network services are provided in the network. Therefore, we propose an offload method for traffic distribution based on service identification to service processing parts, which process the packets for each network service appropriately. This method does not require additional functions in user terminals, and it more scalable than the method in which all traffic undergoes the service identification process. However, control of the proposed method is slightly more complex, so we established a control procedure and checked it in combination with user terminals. In addition, we evaluated by theoretical analysis the scalability of traffic distribution with offload compared to the method without offload. The results showed that the proposed offload method can increase the scalability of traffic distribution based on service identification.
Contact-electromigration-induced leakage failure in aluminum-silicon to silicon contacts (1985)

Si migration is observed in AI-Si contacts to both n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> and p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> silicon. Etch pits axe found near the leading edges of the more positively biased contacts. Leakage failure is observed in n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> contacts, but despite the Si migration, no junction leakage increase is measurable in Al-Si to p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> Si contacts. In n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> contacts, the leakage mean time to failure (MTF) is found to have an activation energy of 0.83 eV and be inversely proportional to the current density at the leading edge of the contacts. A current crowding parameter and an effective current are defined which enable the prediction of MTF with contact and technology scaling. In a typical case, current crowding is so severe that at constant current, changes in contact length have little effect on MTF.
Mutations in the fission yeast silencing factors <i>clr4</i> <i>+</i> and <i>rik1</i> <i>+</i> disrupt the localisation of the chromo domain protein Swi6p and impair centromere function (1996)

Transcriptional silencing is known to occur at centromeres, telomeres and the mating type region in the nucleus of fission yeast, Schizosaccharomyces pombe. Mating-type silencing factors have previously been shown also to affect transcriptional repression within centromeres and to some extent at telomeres. Mutations in the clr4+, rik1+ and swi6+ genes dramatically reduce silencing at certain centromeric regions and cause elevated chromosome loss rates. Recently, Swi6p was found to co-localise with the three silent chromosomal regions. Here the involvement of clr4+, rik1+ and swi6+ in centromere function is investigated in further detail. Fluorescence in situ hybridisation (FISH) was used to show that, as in swi6 mutant cells, centromeres lag on late anaphase spindles in clr4 and rik1 mutant cells. This phenotype is consistent with a role for these three gene products in fission yeast centromere function. The Swi6 protein was found to be delocalised from all three silent chromosomal regions, and dispersed within the nucleus, in both clr4 and rik1 mutant cells. The phenotypic similarity observed in all three mutants is consistent with the products of both the clr4+ and rik1+ genes being required to recruit Swi6p to the centromere and other silent regions. Mutations in clr4, rik1 and swi6 also result in elevated sensitivity to reagents which destabilise microtubules and show a synergistic interaction with a mutation in the beta-tubulin gene (nda3). These observations suggest that clr4+ and rik1+ must play a role in the assembly of Swi6p into a transcriptionally silent, inaccessible chromatin structure at fission yeast centromeres which is required to facilitate interactions with spindle microtubules and to ensure normal chromosome segregation.