gebhart/patrepeval huggingface dataset:
Neurofuzzy modelling approaches in system identification (1997)

System identification is the task of constructing representative models of processes and has become an invaluable tool in many different areas of science and engineering. Due to the inherent complexity of many real world systems the application of traditional techniques is limited. In such instances more sophisticated (so called intelligent) modelling approaches are required. Neurofuzzy modelling is one such technique, which by integrating the attributes of fuzzy systems and neural networks is ideally suited to system identification. This attractive paradigm combines the well established learning techniques of a particular form of neural network i.e. generalised linear models with the transparent knowledge representation of fuzzy systems, thus producing models which possess the ability to learn from real world observations and whose behaviour can be described naturally as a series of linguistic humanly understandable rules. Unfortunately, the application of these systems is limited to low dimensional problems for which good quality expert knowledge and data are available. The work described in this thesis addresses this fundamental problem with neurofuzzy modelling, as a result algorithms which are less sensitive to the quality of the a priori knowledge and empirical data are developed. The true modelling capabilities of any strategy is heavily reliant on the model's structure, and hence an important (arguably the most important) task is structure identification. Also, due to the curse of dimensionality, in high dimensional problems the size of conventional neurofuzzy models gets prohibitively large. These issues are tackled by the development of automatic neurofuzzy model identification algorithms, which exploit the available expert knowledge and empirical data. To alleviate problems associated with the curse of dimensionality, aid model generalisation and enhance model transparency, parsimonious models are identified. This is achieved by the application of additive and multiplicative neurofuzzy models which exploit structural redundancies found in conventional systems. The developed construction algorithms successfully identify parsimonious models, but as a result of noisy and poorly distributed empirical data, these models can still generalise inadequately. This problem is addressed by the application of Bayesian inferencing techniques; a form of regularisation. Smooth model outputs are assumed and superfluous model parameters are controlled, sufficiently aiding model generalisation and transparency, and data interpolation and extrapolation. By exploiting the structural decomposition of the identified neurofuzzy models, an efficient local method of regularisation is developed. All the methods introduced in this thesis are illustrated on many different examples, including simulated time series, complex functional equations, and multi-dimensional dynamical systems. For many of these problems conventional neurofuzzy modelling is unsuitable, and the developed techniques have extended the range of problems to which neurofuzzy modelling can successfully be applied.
Eukaryotic DNA Ligases: Structural and Functional Insights (2008)

DNA ligases are required for DNA replication, repair, and recombination. In eukaryotes, there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV families are found in all eukaryotes, whereas DNA ligase III family members are restricted to vertebrates. These enzymes share a common catalytic region comprising a DNA-binding domain, a nucleotidyltransferase (NTase) domain, and an oligonucleotide/oligosaccharide binding (OB)-fold domain. The catalytic region encircles nicked DNA with each of the domains contacting the DNA duplex. The unique segments adjacent to the catalytic region of eukaryotic DNA ligases are involved in specific protein-protein interactions with a growing number of DNA replication and repair proteins. These interactions determine the specific cellular functions of the DNA ligase isozymes. In mammals, defects in DNA ligation have been linked with an increased incidence of cancer and neurodegeneration.
ELECTRONIC RECORDER STUDY (1998)

Federal Highway Administration, Office of Motor Carriers, Washington, D.C.
A Tetracoordinated Phosphasalen Nickel(III) Complex (2013)

The oxidation of a Ni(II) complex bearing a tetradentate phosphasalen ligand, which differs from salen by the presence of an iminophosphorane (PN) in place of an imine unit, was easily achieved by addition of a silver salt. The site of this oxidation was investigated with a combination of techniques (NMR, EPR, UV/Vis spectroscopy, X-ray diffraction, magnetic measurements) as well as DFT calculations. All data are in agreement with a high-valent Ni(III) center concentrating the spin density. This markedly differs from precedents in the salen series for which oxidation on the metal was only observed at low temperature or in the presence of additional ligands or anions. Therefore, thanks to the good electron-donating properties of the phosphasalen ligand, [Ni(Psalen)](+) represents a rare example of a tetracoordinated high-valent nickel complex in presence of a phenoxide ligand.
Granular Activated Carbon in Water Treatment (1977)

The state of the art of granular activated carbon filtration is reviewed in detail with research needs noted.
Atypical Chronic Lung Disease Patterns in Neonates (1999)

Atypical CLD comprised 31% of total cases of CLD. Atypical CLD appears to be less severe than classic BPD. These data suggest that initial, acute lung injuries are not the sole antecedents of neonatal CLD.
Using <i>Saccharomyces cerevisiae</i> to Test the Mutagenicity of Household Compounds: An Open Ended Hypothesis-Driven Teaching Lab (2007)

In our Fundamentals of Genetics lab, students perform a wide variety of labs to reinforce and extend the topics covered in lecture. I developed an active-learning lab to augment the lecture topic of mutagenesis. In this lab exercise, students determine if a compound they bring from home is a mutagen. Students are required to read extensive background material, perform research to find a potential mutagen to test, develop a hypothesis, and bring to the lab their own suspected mutagen. This lab uses a specially developed strain of Saccharomyces cerevisiae, D7, to determine if a compound is a mutagen. Mutagenesis of the D7 genome can lead to a scorable alteration in the phenotypes of this strain. Students outline and carry out a protocol for treatment of the yeast tester strain, utilizing the concept of dose/response and positive and negative controls. Students report on their results using a PowerPoint presentation to simulate giving a scientific presentation. The students' self-assessment of their knowledge indicated that, in all cases, the students felt that they knew more about the assay, mutagenesis, and the relationship between genotype and phenotype (P < 0.05) after completing the exercise.
Effect of chitosan on weight loss in overweight and obese individuals: a systematic review of randomized controlled trials (2005)

This article aims to determine whether chitosan, a popular, over-the-counter, weight loss supplement, is an effective treatment for overweight and obesity. It is designed as a systematic review of randomized controlled trials. The data sources include the electronic databases Medline, EMBASE, Biosis, CINAHL and Cochrane Central Register of Controlled Trials (CCTR); the specialized websites Controlled Trials, International Bibliographic Information on Dietary Supplements (IBIDS), System for Information on Grey Literature in Europe (SIGLE), Reuter's Health Service, Natural Alternatives International and Pharmanutrients; and bibliographies of relevant journal articles. Included were randomized controlled trials of chitosan with a minimum duration of 4 weeks in adults who were overweight or obese and/or had hypercholesterolaemia at baseline. Fourteen trials involving a total of 1071 participants were included in the review. Analyses involving all trials indicated that chitosan preparations result in a small but statistically significant greater reduction in body weight (weighted mean difference -1.7 kg; 95% confidence interval -2.1, -1.3 kg, P < 0.00001) compared with placebo. Analyses restricted to high-quality studies showed that reductions in weight [-0.6 (-1.2, 0.1) kg, P = 0.11] were less than in lower quality studies [-2.3 (-2.7, -1.8) kg, P < 0.00001]. Results obtained from high-quality trials indicate that the effect of chitosan on body weight is minimal and unlikely to be of clinical significance.
High Energy Density Na-Ion Batteries Through Electrolyte Optimization (2013)

Abstract not Available.
Movement of Crystal Inclusions in a Centrifugal Field (1971)

A centrifugal field can cause migration of solvent inclusions in crystals, both by the preferential sedimentation of the denser solute ions and by diffusion across the concentration gradient caused by the variation of solubility with pressure. The two mechanisms can act either in the same or in opposite directions so that both centripetal and centrifugal migration are possible. Aqueous inclusions in KI were observed to move centripetally at about 0.05 mm/h at room temperature in centrifugal fields of 210 000 G; at higher temperatures the direction of migration was reversed. Inclusion movement was also observed in KCl and Pb(NO3)2. Plastic deformation, cracking, and changes in inclusion shape were also encountered.
Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre‐elafin (trappin‐2) expressed in <i>Pichia pastoris</i> (2004)

Elafin and its precursor, trappin-2 or pre-elafin, are specific endogenous inhibitors of human neutrophil elastase and proteinase 3 but not of cathepsin G. Both inhibitors belong, together with secretory leukocyte protease inhibitor, to the chelonianin family of canonical protease inhibitors of serine proteases. A cDNA coding either elafin or its precursor, trappin-2, was fused in frame with yeast alpha-factor cDNA and expressed in the Pichia pastoris yeast expression system. Full-length elafin or full-length trappin-2 were secreted into the culture medium with high yield, indicating correct processing of the fusion proteins by the yeast KEX2 signal peptidase. Both recombinant inhibitors were purified to homogeneity from concentrated culture medium by one-step cationic exchange chromatography and characterized by N-terminal amino acid sequencing, Western blot and kinetic studies. Both recombinant elafin and trappin-2 were found to be fast-acting inhibitors of pancreatic elastase, neutrophil elastase and proteinase 3 with k(ass) values of 2-4 x 10(6) m(-1).s(-1), while dissociation rate constants k(diss) were found to be in the 10(-4) s(-1) range, indicating low reversibility of the complexes. The equilibrium dissociation constant K(i) for the interaction of both recombinant inhibitors with their target enzymes was either directly measured for pancreatic elastase or calculated from k(ass) and k(diss) values for neutrophil elastase and proteinase 3. K(i) values were found to be in the 10(-10) molar range and virtually identical for both inhibitors. Based on the kinetic parameters determined here, it may be concluded that both recombinant elafin and trappin-2 may act as potent anti-inflammatory molecules and may be of therapeutic potential in the treatment of various inflammatory lung diseases.
Activation of Endothelin ETA Receptors Induces Phosphorylation of α1b-Adrenoreceptors in Rat-1 Fibroblasts (1997)

The effect of endothelin-1 on the phosphorylation of alpha1b-adrenoreceptors, transfected into rat-1 fibroblasts, was studied. Basal alpha1b-adrenoreceptor phosphorylation was markedly increased by endothelin-1, norepinephrine, and phorbol esters. The effect of endothelin-1 was dose dependent (EC50 approximately 1 nM), reached its maximum 5 min after stimulation, and was inhibited by BQ-123, an antagonist selective for ETA receptors. Endothelin-1-induced alpha1b-adrenoreceptor phosphorylation was attenuated by staurosporine or genistein and essentially abolished when both inhibitors were used together. The effect of norepinephrine was not modified by either staurosporine or genistein alone, and it was only partially inhibited when both were used together. These data suggest the participation of protein kinase C and tyrosine kinase(s) in endothelin-1-induced receptor phosphorylation. However, phosphoaminoacid analysis revealed the presence of phosphoserine and traces of phosphothreonine, but not of phosphotyrosine, suggesting that the putative tyrosine kinase(s), activated by endothelin, could act in a step previous to receptor phosphorylation. The effect of endothelin-1 on alpha1b-adrenoreceptor phosphorylation was not mediated through pertussis toxin-sensitive G proteins. Calcium mobilization induced by norepinephrine was diminished by endothelin-1. Norepinephrine and endothelin-1 increased [35S]GTPgammaS binding to control membranes. The effect of norepinephrine was abolished in membranes obtained from cells pretreated with endothelin-1. Interestingly, genistein plus staurosporine inhibited this effect of the endothelial peptide. Endothelin-1 did not induce alpha1b-adrenoreceptor internalization. Our data indicate that activation of ETA receptors by endothelin-1 induces alpha1b-adrenoreceptor phosphorylation and alters G protein coupling.
Multiobjective Time Series Matching for Audio Classification and Retrieval (2013)

Seeking sound samples in a massive database can be a tedious and time consuming task. Even when metadata are available, query results may remain far from the timbre expected by users. This problem stems from the nature of query specification, which does not account for the underlying complexity of audio data. The Query By Example (QBE) paradigm tries to tackle this shortcoming by finding audio clips similar to a given sound example. However, it requires users to have a well-formed soundfile of what they seek, which is not always a valid assumption. Furthermore, most audio-retrieval systems rely on a single measure of similarity, which is unlikely to convey the perceptual similarity of audio signals. We address in this paper an innovative way of querying generic audio databases by simultaneously optimizing the temporal evolution of multiple spectral properties. We show how this problem can be cast into a new approach merging multiobjective optimization and time series matching, called MultiObjective Time Series (MOTS) matching. We formally state this problem and report an efficient implementation. This approach introduces a multidimensional assessment of similarity in audio matching. This allows to cope with the multidimensional nature of timbre perception and also to obtain a set of efficient propositions rather than a single best solution. To demonstrate the performances of our approach, we show its efficiency in audio classification tasks. By introducing a selection criterion based on the hypervolume dominated by a class, we show that our approach outstands the state-of-art methods in audio classification even with a few number of features. We demonstrate its robustness to several classes of audio distortions. Finally, we introduce two innovative applications of our method for sound querying.
High Levels of Brain Dolichols in Neuronal Ceroid‐Lipofuscinosis and Senescence (1983)

Dolichols as unesterified alcohols were identified as significant components of lipid extracts from storage cytosomes isolated post-mortem from the brains of patients with the infantile, late infantile, and juvenile types of neuronal ceroid-lipofuscinosis (NCL). Very small amounts of dolichols were present in the corresponding subcellular fractions of non-NCL brains. The nuclear fraction from NCL cerebral cortex contained the highest dolichol content expressed per milligram protein or lipid, whereas the crude mitochondrial fraction was the richest in normal brain. Highly significant elevations of dolichol levels were found in human cerebral cortex of patients with NCL and Alzheimer's disease compared with age-matched controls, but the levels were normal in Pick's disease. In human non-NCL cerebral cortex, dolichols increased from 16 micrograms/g at age 5 to over 200 at age 81. Rat cerebral cortex showed a similar progressive increase in dolichol content with age. The high dolichol values in NCL, Alzheimer's disease, and senescence appears to be related to the increase of lipofuscin in brain. This is the first time a uniform biochemical abnormality has been found in all childhood forms of NCL, but the enzyme defect is still unidentified. It may lie on pathways where dolichols and retinyl compounds are recycled in Golgi membranes and derived organelles during the biosynthesis of glycoproteins.
Computer-based systems (1993)

Much of the current work into developing computer-based systems (CBS) as aids for managerial decision-making within organizations, still explains system failures as a psychological or organizational problem, i.e. a problem of inadequate “acceptance” of the CBS by the intended user. From this, the conclusion is drawn that “more” behavioural science research on user psychology can save the CBS-managerial decision-support concept. However, the underlying design ideal of CBS and the assumption of rational decision-making within organizations remains unquestioned. Any moves to question this ideal generally rest upon the issues of tool design in terms of providing alternative modes of information presentation in response to psychological “user types” and problem categories.This paper questions the ideals of rational managerial decision-making and the resulting paradigm of computer system support. It suggests that for effective support, the normative content (the political and moral foundations) of system design must be subject to critical appraisal to secure social rationality for use of CBS within organizational activities.
Synthesis and Application of Polymer‐Supported Chiral Brønsted Acid Organocatalysts (2010)

Abstract A new methodology for the immobilization of chiral Brønsted acids has been developed. The resulting heterogeneous organocatalysts have been employed in multiple consecutive catalysis cycles in the asymmetric organocatalytic transfer hydrogenation. The new catalyst system can not only be easily recovered from the reaction mixture in a tea‐bag approach but it can also be easily reused in several catalytic cycles without loss of reactivity and selectivity.
Visualizing Gene-Set Enrichment Results Using the Cytoscape Plug-in Enrichment Map (2011)

Gene-set enrichment analysis finds functionally coherent gene-sets, such as pathways, that are statistically overrepresented in a given gene list. Ideally, the number of resulting sets is smaller than the number of genes in the list, thus simplifying interpretation. However, the increasing number and redundancy of -gene-sets used by many current enrichment analysis resources work against this ideal. "Enrichment Map" is a Cytoscape plug-in that helps overcome gene-set redundancy and aids in the interpretation of enrichment results. Gene-sets are organized in a network, where each set is a node and links represent gene overlap between sets. Automated network layout groups related gene-sets into -network clusters, enabling the user to quickly identify the major enriched functional themes and more easily interpret enrichment results.
Synthesis of 2-azetidinones from serinehydroxamates: approaches to the synthesis of 3-aminonocardicinic acid (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-azetidinones from serinehydroxamates: approaches to the synthesis of 3-aminonocardicinic acidPhillip G. Mattingly and Marvin J. MillerCite this: J. Org. Chem. 1981, 46, 8, 1557–1564Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/jo00321a007https://doi.org/10.1021/jo00321a007research-articleACS PublicationsRequest reuse permissionsArticle Views548Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preferred orientation in Cr- and Co-based thin films and its effects on the read/write performance of the media (1992)

This work investigates the formation of preferred crystallographic orientation (PO) in Cr underlayer as well as CoCrTa and CoCrPtTa thin films and its effects on the recording performance of longitudinal media. The results show that the thin-film media with comparable coercivity but different crystalline PO as measured by x-ray diffraction exhibit significant difference in high-frequency signal amplitude, pulse width, and signal-to-noise ratio. To illustrate the effect of PO on parametric performance, CoCrTa/Cr and CoCrPtTa/Cr media were sputtered on different substrates and/or using special sputtering processes to achieve comparable coercivity but different PO in the films. A PO of Cr(200), which normally occurs on the NiP/Al substrates under adequate sputtering conditions, is found to be the key to obtaining a PO of Co(11.0) in Co-alloy media. The consequence of preferred in-plane c-axis orientation is a higher coercivity and better parametric performance of the medium. The formation of PO in the Cr underlayer is found to be related to the substrate material and the oxygen content in the sputtered films. The nonmetallic canasite substrates tend to promote PO of more stable Cr(110) rather than Cr(200). Consequently, this leads to a PO of out-of-plane c axis on the following Co films. The PO of magnetic layer appears to be an important factor in determining the parametric performance of the media.
Nonsteroid Antiinflammatory Agents (1966)

The drugs with which this review will be concerned are those which are useful in the treatment of connective tissue diseases. These disorders are characterized by chronic inflammation, and the drugs used to treat them have the ability to inhibit one or more of the manifestations of inflammation. Arthritis is a term used to indicate ‘articular inflammation and is a sign of disease and not a diagnosis’ [10].
Modeling Piano Tones with Group Synthesis (1999)

Most synthesizers and sound cards use sampling to synthesize the piano. Sampling requires a lot of memory and does not allow much flexibility, unlike methods such as wavetable synthesis. However, wavetable synthesis usually assumes that the original tone is harmonic, and the piano's stretched partials make it difficult to model. It is shown how to simulate piano tones using group synthesis, a special case of wavetable synthesis. The synthesis model uses nearly contiguous groups selected by a genetic algorithm, and independent frequency deviations for each group to simulate partial stretching. The model reduces the amount of data by about 50% compared to additive synthesis, while preserving the perceptual identity of the sound. Listening test results indicate that the synthesized piano tones are perceptually similar to the originals.