gebhart/patrepeval huggingface dataset:
Post-operative Stapedius Reflex Tests with Simultaneous Loudness Scaling in Patients Supplied with Cochlear Implants (2000)

The estimation of the maximum comfort loudness levels (MCL) by measurements of the electrically elicited stapedius reflex was examined in six experienced cochlear implant users supplied with the COMBI 40 implant system. The stapedius reflex was tested and loudness scaling was performed simultaneously using an up/down stimulation protocol close to the reflex threshold with automated recording of both test procedures. The electrical stapedius reflex threshold (ESRT) and loudness scaling were evaluated separately. Scaling at the reflex threshold ranged between normal and loud. The range of stimulus intensities corresponding to ESRT is much smaller than that at a particular loudness category. The overall correlation between ESRT and MCL was high (r=0.92), with a similar dependence of ESRT and MCL on the channel stimulated. Thus, when the stapedius reflex can be detected post-operatively, the ESRT can be applied successfully for the fitting procedure of the speech processor. Simultaneous loudness scaling during the entire reflex test showed that overstimulation via the implant can be avoided effectively.
Rôle de la Prohibitine et de la sumoylation dans la pathogenèse de l’ostéoarthrose (2010)

L'ostéoarthrose (OA) est la forme la plus commune d’arthrite et son étiologie demeure encore méconnue. Les travaux du Dr Moreau et son équipe ont permis de mettre en évidence une quasi perte d’expression du facteur de transcription Pitx1 dans les chondrocytes OA et la protéine PHB-1 a été identifiée comme étant membre d’un complexe répresseur pouvant lier le promoteur de Pitx1. Le but de la présente étude était de confirmer l’accumulation anormale de PHB-1 dans le noyau des chondrocytes OA, tel que suggéré par des données préliminaires, et d’identifier les mécanismes impliqués dans son import ou rétention au noyau. Pour ce faire, un volet mécanistique utilisant les lignées C28/I2 et U2OS fut combiné à l’étude clinique des chondrocytes articulaires de patients OA et de sujets sains. Les résultats de cette étude démontrent que chez 55 pourcent des patients OA, la Prohibitine s’accumule dans le noyau des chondrocytes articulaires et que cette accumulation corrèle avec une augmentation de la sumoylation totale dans le noyau des cellules OA. Le présent projet de recherche propose pour la première fois qu’une sumoylation accrue au sein des cellules OA pourrait être responsable de l’accumulation nucléaire de PHB-1, médiée par sa liaison aux protéines SUMO-1 via un domaine de liaison aux SUMOs (SBM) localisé aux résidus 76 à 79 de PHB-1. Les résultats de cette étude ont aussi permis de mettre en évidence que dans les chondrocytes OA, les protéines SUMO-1 et SUMO-2/3 s’accumulent dans des corps nucléaires de type PML, suggérant un recrutement de protéines interagissant avec les SUMOs au sein de ces structures dans les cellules OA. Nous sommes persuadés que cette étude générera des retombées importantes non seulement au niveau fondamental pour la compréhension des mécanismes moléculaires liés à la biologie des chondrocytes articulaires, mais aussi au niveau du développement d’outils génétiques permettant le dépistage de l’arthrose à un stade précoce.
Active GaAs MMIC band-pass filters with automatic frequency tuning and insertion loss control (1995)

This paper presents the design and measured performance of active tunable band-pass MMIC filters and matched MMIC control circuits, both fabricated using a standard 1-/spl mu/m GaAs MESFET foundry process. The control circuits generate filter frequency-tuning and Q-control bias voltages by using a dual-loop master-slave control scheme. Separate 3-section filters cover 1.5-2.0 and 1.96-2.64-GHz bands with 3-dB bandwidths of 86/spl plusmn/6 and 126/spl plusmn/1.0 MHz, respectively. The control circuits automatically maintain the filter insertion loss to within /spl plusmn/0.5 dB over these tuning ranges, and regulate the center frequency and insertion loss to within better than /spl plusmn/1.2 MHz and /spl plusmn/0.3 dB over a temperature range of -50/spl deg/C to +75/spl deg/C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Propofol in rabbits. 2. Long-term anesthesia. (1993)

The cardiopulmonary effects of propofol as the sole anesthetic agent administered as a continuous intravenous infusion over 8 hours were evaluated in ten ventilated New Zealand White rabbits. Heart rate, mean blood pressure, arterial oxygen and carbon dioxide tensions, arterial pH, hemoglobin's saturation with oxygen, packed cell volume, and temperature were continuously monitored and recorded at 0 (baseline), 30, 60, 120, 180, 240, 300, 360, 420, and 480 minutes and then hourly for up to 4 hours during recovery. Only light planes of anesthesia could be achieved with a mean propofol infusion rate of 0.876 mg/kg/min. Hypotension and hypoxemia were common features. Four rabbits did not survive the study period and recovery was slow in the surviving animals. With monitoring being the same, Intralipid 10%, the vehicle of propofol, infused into two rabbits (controls) had no adverse effects. Intravenous administration of propofol alone cannot be recommended for long-term anesthesia in the rabbit. Oxygen supplementation appears to be an important element in improving quality of anesthesia and outcome.
5 Gbit/s optical phase diversity homodyne detection experiment (1989)

A 5 Gbit/s phase diversity homodyne detection experiment has been performed by using a high-speed 1.5 μm distributedfeedback laser diode with frequency-shift-keying modulation, 3×3 optical fibre coupler for a 120° optical hybrid, three matched wideband receivers and wideband squaring circuits for signal demodulation.
Efficacy of RIX4414 Live Attenuated Human Rotavirus Vaccine in Finnish Infants (2004)

RIX4414 strain of G1 human rotavirus vaccine was well-tolerated, immunogenic and efficacious in infants against rotavirus gastroenteritis during a 2-year period. To further increase vaccine "take" and efficacy, a higher dose of this vaccine may be considered for future efficacy trials.
Testing of Visual Field with Virtual Reality Goggles in Manual and Visual Grasp Modes (2014)

Automated perimetry is used for the assessment of visual function in a variety of ophthalmic and neurologic diseases. We report development and clinical testing of a compact, head-mounted, and eye-tracking perimeter (VirtualEye) that provides a more comfortable test environment than the standard instrumentation. VirtualEye performs the equivalent of a full threshold 24-2 visual field in two modes: (1) manual, with patient response registered with a mouse click, and (2) visual grasp, where the eye tracker senses change in gaze direction as evidence of target acquisition. 59 patients successfully completed the test in manual mode and 40 in visual grasp mode, with 59 undergoing the standard Humphrey field analyzer (HFA) testing. Large visual field defects were reliably detected by VirtualEye. Point-by-point comparison between the results obtained with the different modalities indicates: (1) minimal systematic differences between measurements taken in visual grasp and manual modes, (2) the average standard deviation of the difference distributions of about 5 dB, and (3) a systematic shift (of 4-6 dB) to lower sensitivities for VirtualEye device, observed mostly in high dB range. The usability survey suggested patients' acceptance of the head-mounted device. The study appears to validate the concepts of a head-mounted perimeter and the visual grasp mode.
Injectable Polymeric Microspheres with X-ray Visibility. Preparation, Properties, and Potential Utility as New Traceable Bulking Agents (2003)

The copolymer of methyl methacrylate (MMA) and 2-[2',3',5'-triiodobenzoyl]oxoethyl methacrylate (1), ratio 3:1 (mass:mass), was prepared via a free-radical polymerization in bulk. The copolymer (M(w) = 97.8 kD and M(n) = 41.5 kD) was dissolved in chloroform and subsequently transformed into beads with a diameter in the micrometer range, using a solvent evaporation technique. The resulting microbeads were characterized by different techniques, including NMR spectroscopy, differential scanning calorimetry, gel permeation chromatography, and scanning electron microscopy. The latter technique was used as the basis for statistical analysis of the bead size. Typically, an average diameter of 96 microm and a standard deviation of 21 microm were obtained. The beads were also subjected to some preliminary tests regarding cytotoxicity. The copolymer of MMA and 1 contains covalently bound iodine. Therefore, the material is intrinsically radiopaque, i.e., capable of absorbing X-radiation while no contrast additive is needed. Our interest in these microspheres stems primarily from their possible utility as injectable and afterward traceable (radiopaque) bulking agents, e.g., for use in urology for the treatment of female stress incontinence due to sphincter deficiency. As a first test into this direction, a sample of the microbeads was mixed with ethylene glycol, and the resulting suspension was studied with respect to injectability and radiopacity. The results suggest that the radiopaque microbeads may provide access to improved bulking agents. Further modification of the surface may be necessary in order to suppress the migratory aptitude of the radiopaque polymeric microspheres in vivo.
Equivalent substitution method-based failures analysis for electromagnetic loop (2012)

A new electromagnetic loop with Voltage Class of 500kv and 220kv are constantly generated when 500kv power network is being constructed in China. Optimizing for the existing layering partition is of great significance to the safety and stably operation of the grid. The short circuit current calculation is crucial to the selection of grid's equipment and scheme for layering partition between electromagnetic loop ring opening and electromagnetic loop ring. This paper presents a new concept of model for power systems calculations based on the operational curve law. The model takes power system model as points stand for electrical components and lines which stands for logical relationship, and this model is established based on the grid characteristic of electromagnetic loop, it can be used for failure analysis on short circuit in electromagnetic loop. The simulation results show that the model has a high fitness and reliability for electromagnetic loop, though the considerations of transfer impedance are still insufficient, this new model has a very large dominant position from traditional algorithm in calculating short circuit current for electromagnetic loop.
Access-Path Abstraction: Scaling Field-Sensitive Data-Flow Analysis with Unbounded Access Paths (T) (2015)

Precise data-flow analyses frequently model field accesses through access paths with varying length. While using longer access paths increases precision, their size must be bounded to assure termination, and should anyway be small to enable a scalable analysis. We present Access-Path Abstraction, which for the first time combines efficiency with maximal precision. At control-flow merge points Access-Path Abstraction represents all those access paths that are rooted at the same base variable through this base variable only. The full access paths are reconstructed on demand where required. This makes it unnecessary to bound access paths to a fixed maximal length. Experiments with Stanford SecuriBench and the Java Class Library compare our open-source implementation against a field-based approach and against a field-sensitive approach that uses bounded access paths. The results show that the proposed approach scales as well as a field-based approach, whereas the approach using bounded access paths runs out of memory.
Improving Classification Accuracy by Comparing Local Features through Canonical Correlations (2010)

Classifying images using features extracted from densely sampled local patches has enjoyed significant success in many detection and recognition tasks. It is also well known that generally more than one type of feature is needed to achieve robust classification performance. Previous works using multiple features have addressed this issue either through simple concatenation of feature vectors or through combining feature specific kernels at the classifier level. In this work we introduce a novel approach for combining features at the feature level by projecting two types of features onto two respective subspaces in which they are maximally correlated. We use their correlation as an augmented feature and demonstrate improvement in classification accuracy over simple combination through concatenation in a pedestrian detection framework.
ChemInform Abstract: The Preparation and Fungicidal Activity of a Series of Thiazolyl‐ and Isothiazolyl‐diarylcarbinols. (1988)

Abstract The title compounds (IIIc), (IIIe), (Va) and (Vd) show fungicidal activity in vivo and in vitro.
A Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Study to Evaluate the Efficacy and Safety of Treatment With Sirukumab (CNTO 136) in Patients With Active Lupus Nephritis (2016)

This proof-of-concept study did not demonstrate the anticipated efficacy nor did it demonstrate an acceptable safety profile for sirukumab treatment in this population of patients with active LN receiving concomitant immunosuppressive treatment.
A general theory of linear time-invariant adaptive feedforward systems with harmonic regressors (2000)

Establishes necessary and sufficient conditions for an adaptive system with a harmonic regressor (i.e., a regressor comprised exclusively of sinusoidal signals) to admit an exact linear time-invariant (LTI) representation. These conditions are important because a large number of adaptive systems used in practice have sinusoidal regressors, and the stability and performance of such systems having LTI representations can be completely analyzed by well-known methods. The theory is extended to applications where the LTI conditions do not hold, in which case the harmonic adaptive system can be written as the parallel connection of a purely LTI subsystem and a linear time-varying (LTV) subsystem. An explicit upper bound is established on the induced two-norm of the LTV block, which allows systematic treatment using emerging robust control methods applicable to LTI systems with norm-bounded LTV perturbations.
Phosphate and other Builder Systems - a Worldwide Comparison (2003)

Since years powder detergents in large parts of Western Europe no longer contain phosphate builders. Currently builders based on Zeolite ion exchangers are most widespread. Newer developments in Europe brought totally soluble builders without phosphate or Zeolite to the market. Besides Europe, other highly industrialized regions where phosphate-free powder detergents meet standard are North America, Japan and South Korea. In China more and more regions issue phosphate bans. Worldwide, however, phosphate still is the predominant builder in high performance detergents. It is found throughout Central and South America, Africa, Eastern Europe and Asia. In different countries national standards require minimum phosphate contents in powder detergents. Very cheap powders often only comprise soda ash as builder like in India.
Efficient Millimeter Wave Doherty PA Design Based on a Low-Loss Combiner Synthesis Technique (2017)

We report on a record-efficient 30-GHz 21-dBm differential Doherty PA designed in a 130-nm SiGe process. The output network is designed using a recently developed combiner synthesis technique. This technique enables impedance inversion and parasitic compensation to be integrated in one compact network. As a result, the combiner loss is reduced with 0.3-0.5 dB compared with a conventional Doherty combiner. The measured collector and power-added efficiencies at 6-dB back-off level are 30% and 24.3%, respectively, which further validates the advantages of the design technique.
5-Amino-2,4-diphenyl-7-(pyrrolidin-1-yl)-1,6-naphthyridine-8-carbonitrile (1998)

In the title molecule, C25H21N5, the naphthyridine ring system is almost planar. The phenyl ring planes form dihedral angles of 28.00 (5) and 84.80 (5)° with the attached ring. Conformational disorder is observed in the pyrrolidine ring and both conformers adopt half-chair conformations. In the solid state, the molecules are linked to form centrosymmetrically related hydrogen-bonded dimers.
Antithrombins as conjunctive therapy in arterial thrombolysis (1992)

Zoldhelyi, Pierre MD; Fuster, Valentin MD, PhD; Chesebro, James H. MD Author Information
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy (2008)

Stimulation through the B-cell antigen receptor (BCR) is believed to be involved in the natural history of chronic lymphocytic leukemia (CLL). Some cases respond to the in vitro cross-linking of surface immunoglobulin (sIg) with effective activation. In contrast, the remaining cases do not respond to such stimulation, thereby resembling B cells anergized after antigen encounter in vivo. However the biochemical differences between the 2 groups are ill defined, and in humans the term B-cell anergy lacks a molecular definition. We examined the expression and activation of key molecules involved in signaling pathways originating from the BCR, and we report that a proportion of CLL patients (a) expresses constitutively phosphorylated extracellular signal-regulated kinase (ERK)1/2 in the absence of AKT activation; (b) displays constitutive phosphorylation of MEK1/2 and increased nuclear factor of activated T cells (NF-AT) transactivation; and (c) is characterized by cellular unresponsiveness to sIg ligation. This molecular profile recapitulates the signaling pattern of anergic murine B cells. Our data indicate that constitutive activation of mitogen activated protein (MAP) kinase signaling pathway along with NF-AT transactivation in the absence of AKT activation may also represent the molecular signature of anergic human B lymphocytes. CLL cases with this signature may be taken as a human model of anergic B cells aberrantly expanded.
CD40 Ligation Prevents<i>Trypanosoma cruzi</i>Infection through Interleukin-12 Upregulation (1999)

Because of the critical role of the CD40-CD40 ligand (CD40L) pathway in the induction and effector phases of immune responses, we investigated the effects of CD40 ligation on the control of Trypanosoma cruzi infection. First, we observed that supernatants of murine spleen cells stimulated by CD40L-transfected 3T3 fibroblasts (3T3-CD40L transfectants) prevent the infection of mouse peritoneal macrophages (MPM) by T. cruzi. This phenomenon depends on de novo production of nitric oxide (NO) as it is prevented by the addition of N-nitro-L-arginine methyl ester, a NO synthase inhibitor. NO production requires interleukin (IL)-12-mediated gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) synthesis as demonstrated by inhibition experiments using neutralizing anti-IL-12, anti-IFN-gamma, and anti-TNF-alpha monoclonal antibodies (MAb). We found that an activating anti-CD40 MAb also directly stimulates IFN-gamma-activated MPM to produce NO and thereby to control T. cruzi infection. To determine the in vivo relevance of these in vitro findings, mice were injected with 3T3-CD40L transfectants or 3T3 control fibroblasts at the time of T. cruzi inoculation. We observed that in vivo CD40 ligation dramatically reduced both parasitemia and the mortality rate of T. cruzi-infected mice. A reduced parasitemia was still observed when the injection of 3T3-CD40L transfectants was delayed 8 days postinfection. It was abolished by injection of anti-IL-12 MAb. Taken together, these data establish that CD40 ligation facilitates the control of T. cruzi infection through a cascade involving IL-12, IFN-gamma, and NO.
Textbook of Fish Health (1988)

Textbook of fish health , Textbook of fish health , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Surface Plasmon Resonance (SPR) Detection of Theophylline via Electropolymerized Molecularly Imprinted Polythiophenes (2010)

A facile approach to tailor-made, highly selective, and robust ultrathin sensor film for theophylline detection was demonstrated by an electropolymerized molecularly imprinted polymer (E-MIP) film of a terthiophene derivative. The method involved direct electropolymerization of the H-bond complexing terthiophene monomer. A key enabling step in sensor fabrication is the use of an electrochemically mediated washing step of the template. The formation of the E-MIP film was monitored by in situ electrochemical surface plasmon resonance (EC-SPR) spectroscopy, allowing real-time observation of the simultaneous changes in electrochemical and optical properties of the film. Surface characterization techniques for the electropolymerized films include atomic force microscopy (AFM), ellipsometry, static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance (QCM). A linear calibration curve (R = 0.994) of the E-MIP/SPR sensor for theophylline detection was obtained with a 10−50 μM−1 range and a limit of detection (LOD) of 3.36 μM−1. The fabricated E-MIP sensor film showed a homogeneous surface coverage, high sensitivity, long-term stability, and strong selectivity toward the imprinted template molecule. This indicated the formation of precise and stable cavities that retained the exact memory of the size, shape, and orientation of the functional groups during the templating electropolymerization steps.