gebhart/patrepeval huggingface dataset:
Iron-deficiency anaemia enhances red blood cell oxidative stress (2008)

Oxidative stress associated with iron deficiency anaemia in a murine model was studied feeding an iron-deficient diet. Anaemia was monitored by a decrease in hematocrit and haemoglobin. For the 9 week study an increase in total iron binding capacity was also demonstrated. Anaemia resulted in an increase in red blood cells (RBC) oxidative stress as indicated by increased levels of fluorescent heme degradation products (1.24-fold after 5 weeks; 2.1-fold after 9 weeks). The increase in oxidative stress was further confirmed by elevated levels of methemoglobin for mice fed an iron-deficient diet. Increased haemoglobin autoxidation and subsequent generation of ROS can account for the shorter RBC lifespan and other pathological changes associated with iron-deficiency anaemia.
Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1 (2000)

Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and accelerates reendothelialization after mechanical denudation. Two VEGF tyrosine kinase receptors have been reported-fms-like-tyrosine kinase-1 (Flt-1) and kinase domain region (KDR). Little is known about the regulation of the expression of these receptors after vascular injury. Herein, we have analyzed the expression of Flt-1 after mechanical denudation of primary cultures of endothelial cells, which has been considered a useful in vitro model to study endothelium responses to vascular injury. After denudation, the Flt-1 protein and mRNA levels are clearly up-regulated, and transient transfection experiments showed a strong induction of the flt-1 promoter-dependent transcription. Analysis of the flt-1 promoter sequence revealed the presence of a putative binding site for the early growth response factor-1 (Egr-1) at positions -24 to -16. Electrophoretic mobility shift and supershift assays showed that Egr-1 was able to bind to this DNA sequence, and cotransfection of the flt-1 promoter reporter plasmid with an Egr-1 expression vector resulted in enhancement of its transcriptional activity. Furthermore, the mutation of the Egr-1 binding site markedly reduced the denudation-induced flt-1 promoter activity. These data demonstrate that Flt-1 is up-regulated after endothelial denudation and that Egr-1 plays a relevant role in this process.
Turbo product codes on frequency selective fading channel (2003)

In this article, we present a new scheme that combines the turbo product codes with a simple single carrier frequency domain based equalization algorithm. By using transmit diversity in frequency selective Rayleigh fading channels, the system can resist intersymbol interference effectively. Simulation results show that the proposed system offers diversity gain of more than 6 dB.
8000 Pictures per Second (1945)

A brief outline is given of the development and design of the Western Electric Fastax high-speed motion picture camera. This camera takes up to 8000 pictures per sec on 8-mm film.
A compact robotic head for automatic acquisition of indoor panoramic images (2017)

Indoor exploration based on panoramic images has been of interest in both navigation and visualization scenarios of mobile intelligent systems, becoming an appealing research topic in hardware design and computational algorithms. A detailed profile of an indoor scene further used for 3D reconstruction purposes or visualization requires an accurate high-resolution rendering from multiple camera shots. In panoramic imaging, 360 degree Gigapixel panoramas involve a process of capturing multiple segments at a predefined step according to the physical and optical characteristics of the camera (focal length, field of view, angle of view). Manual shooting in such scenes becomes cumbersome, as high precision and stability is required for prolonged time. The current work, proposes a hardware implementation and software control of a panoramic robotized head (GoSphere), used to automatically capture panoramic segments, that further are to be stitched into panoramic renderings. The proposed model features a light-weight portable design for action cameras, allowing a two axes control for a 360 × 180 degree coverage of the scene. Experimental validation has been made in comparison with a standard panoramic capturing assembly. Limitations and improvement proposals are presented for further development and extensions.
The Application of Hemospray in Gastrointestinal Bleeding during Emergency Endoscopy (2017)

<i>Introduction</i>. Gastrointestinal bleeding represents the main indication for emergency endoscopy (EE). Lately, several hemostatic powders have been released to facilitate EE. <i>Methods</i>. We evaluated all EE in which Hemospray was used as primary or salvage therapy, with regard to short- and long-term hemostasis and complications. <i>Results</i>. We conducted 677 EE in 474 patients (488 examinations in 344 patients were upper GI endoscopies). Hemospray was applied during 35 examinations in 27 patients (19 males), 33 during upper and 2 during lower endoscopy. It was used after previous treatment in 21 examinations (60%) and in 14 (40%) as salvage therapy. Short-term success was reached in 34 of 35 applications (97.1%), while long-term success occurred in 23 applications (65.7%). Similar long-term results were found after primary application (64,3%) or salvage therapy (66,7%). Rebleeding was found in malignant and extended ulcers. One major adverse event (2.8%) occurred with gastric perforation after Hemospray application. <i>Discussion</i>. Hemospray achieved short-term hemostasis in virtually all cases. The long-term effect is mainly determined by the type of bleeding source, but not whether it was applied as first line or salvage therapy. But, even in the failures, patients had benefit from hemodynamic stabilization and consecutive interventions in optimized conditions.
A Novel Triple-Rotor Axial-Flux Vernier Permanent Magnet Machine (2016)

Vernier permanent magnet (VPM) machines are obtaining more and more attentions due to their high torque density and low torque ripple feature. Owing to the “magnetic gearing effect,” VPM machines are capable of achieving high torque at low speed, which makes them suitable for direct-drive applications. However, they suffer from low power factor. In this paper, a triple-rotor axial-flux spoke-array vernier permanent magnet (TR-AFSAVPM) machine is proposed to enhance VPM machine power factor to a reasonable level and maintain their high torque density and adequate constant speed range. Both quasi-3-D finite element analysis (FEA) and 3-D-FEA are employed to investigate the proposed machine performances. Analysis results show that the TR-AFSAVPM machine has high power factor, viz. 0.94 and high torque density, viz. 22.87 kNm/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> .
Problems with the superluminal pulsar model (1996)

It has been suggested by Ardavan that the coherent radiation from pulsars could be due to current distributions corotating at superluminal phase speeds beyond the speed-of-light cylinder. Similar distributions moving at phase velocities exceeding the speed of light also occur in travelling-wave antennae. Pulsar models satisfying Ardavan's criteria are readily conceived in terms of antenna theory and are found not to give rise to the surprising radiation characteristics predicted by his analysis. Reasons for the failure of Ardavan's model are discussed.
Guanidine sulfate-assisted synthesis of hexagonal WO<sub>3</sub> nanoparticles with enhanced adsorption properties (2015)

Large surface area hexagonal phase WO3 (h-WO3) nanowires were synthesized by a hydrothermal route with the assistance of C2H12N6O4S. They were characterized by XRD, SEM, TEM, BET, FT-IR and XPS. It is shown that C2H12N6O4S not only acts as a stabilizer to facilitate the generation of a metastable hexagonal phase, but also functions as a structure directing agent to assist the construction of nanowires. The obtained h-WO3 possesses a large specific surface area and numerous adsorption functional groups such as -OH groups. These characteristics result in an excellent adsorption performance for the removal of strontium from acidic aqueous solutions. A maximum adsorption capacity of 52.93 mg g(-1) was achieved on the h-WO3 prepared in the presence of C2H12N6O4S. This value is almost two times higher than that of bare h-WO3 (no C2H12N6O4S). The effects of pH, contact time, initial Sr(2+) concentration and ion strength on Sr(2+) removal from the solution by h-WO3 were systematically investigated. The adsorption mechanism involving the combination of electrostatic attraction and ion exchange for the adsorption of Sr(2+) is proposed. Based on our results, h-WO3 with high adsorption capacity and good surface characteristics exhibits great potential for the removal of Sr(2+) from radioactive wastewater.
Effect of acylation stimulating protein on the triacylglycerol synthetic pathway of human adipose tissue (1991)

Acylation stimulating protein (ASP) is a 14 kDa plasma protein which causes in vitro triacylglycerol synthesis in human adipocytes and fibroblasts to increase substantially. ASP was found to stimulate human adipose tissue microsomal glycerophosphate acyltransferase and diacylglycerol acyltransferase activities by 23% and 90%, respectively. However, phosphatidate phosphohydrolase activity showed no increase in activity, nor did microsomal acyl-CoA synthetase activity. Moreover, ASP did not decrease the apparent Km of diacylglycerol acyltransferase (DGAT), but rather increased its apparent Vmax suggesting direct interaction of ASP with DGAT.
The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. II. The cyanogen bromide peptides. (1979)

Cyanogen bromide cleavage of Fragment A from diphtheria toxin at the four methionines present in each molecule resulted in five major peptides which were isolated and studied by sequence methods. These five peptides of 4, 11, 14, 63, and 101 residues account for all 193 residues in Fragment A and provide overlaps for the tryptic peptides from the maleylated protein. Two additional peptides were isolated and shown to be shorter forms (8 and 10 residues) of the COOH-terminal cyanogen bromide peptide (11 residues).
Role of peptide substrate structure in the selective processing of peptide prohormones at basic amino acid pairs by endoproteases (1988)

Three putative processing enzymes, each with defined action in a prohormone system, a 'pro-ocytocin-neurophysin convertase' from bovine neurohypophysis secretory granules, a 'Leu-enkephalin Arg6 generating enzyme' from human CSF and the endoprotease from the 'S-28 convertase' complex of rat brain cortex, were tested for their ability to hydrolyze peptides deriving from pro-ocytocin, pro-enkephalin B and pro-somatostatin, respectively at pairs of basic amino acids. The observations suggest that structural parameters specified by the peptide region around the dibasic moieties govern recognition by the enzyme and define which peptide bond is hydrolyzed.
Isolation and Properties of a Macromolecular, Water-Soluble, Immuno-Adjuvant Fraction from the Cell Wall of <i>Mycobacterium smegmatis</i> (1972)

Trypsin- and chymotrypsin-treated delipidated cell walls of Mycobacterium smegmatis were digested overnight with lysozyme. The water-soluble products thus obtained were filtered on a column of Sephadex G-50; the first peak, excluded from the column, has immunological adjuvant activity. The material of the excluded peak is obtained after lyophilization as a snow-white, fluffy material, soluble in water and insoluble in organic solvents. It behaves as a slightly polydisperse macromolecule in an ultracentrifuge, with an approximate molecular weight of 20,000. All the constituents of this material are typical bacterial cell-wall constituents; thus, the water-soluble adjuvant is considered to be an "oligomer" of the cell wall. When added to Freund's incomplete adjuvant with an antigen (e.g., ovalbumin) and injected into hind-foot pads of guinea pigs, this water-soluble adjuvant increases the amount of precipitating antibodies and induces hypersensitivity to ovalbumin and the biosynthesis of gamma(2)-type precipitating antibodies. The water-soluble material has a stronger adjuvant activity than equal amounts of whole bacteria, cell walls, or wax D, and seems to be the first well-defined, water-soluble, adjuvant-active fraction isolated from Mycobacteria.
Discovering evolutionary theme patterns from text (2005)

Temporal Text Mining (TTM) is concerned with discovering temporal patterns in text information collected over time. Since most text information bears some time stamps, TTM has many applications in multiple domains, such as summarizing events in news articles and revealing research trends in scientific literature. In this paper, we study a particular TTM task -- discovering and summarizing the evolutionary patterns of themes in a text stream. We define this new text mining problem and present general probabilistic methods for solving this problem through (1) discovering latent themes from text; (2) constructing an evolution graph of themes; and (3) analyzing life cycles of themes. Evaluation of the proposed methods on two different domains (i.e., news articles and literature) shows that the proposed methods can discover interesting evolutionary theme patterns effectively.
Isolation of chromosomal mutations that affect carotenoid production in<i>Escherichia coli</i>: mutations alter copy number of ColE1-type plasmids (2004)

Chromosomal mutants were isolated in <it>Escherichia coli</it> that altered carotenoid production from transformed carotenoid biosynthesis genes on a pACYC-derived plasmid (pPCB15). The mutations were mapped by sequencing. One group of mutations appeared to affect the cell metabolism without changing the copy number of the carotenoid synthesis plasmid. The other group of mutations either increased or decreased the copy number of the pPCB15 plasmid as determined by real-time PCR. The copy number change in most mutants was likely specific for ColE1-type plasmids for which copy number is controlled by a small antisense RNA. This collection of host strains would be useful for fine tuning expression of proteins and adjusting production of desired molecules without recloning to different vectors.
Effect of naloxone on focal cerebral ischemia in cats (1992)

We have examined the effects of a single injection of naloxone (5 mg/kg, i.v.) in cats with cerebral ischemia produced by transorbital occlusion of the middle cerebral artery (MCA). Cerebral blood flow (CBF) was measured and the cerebral metabolic rate of oxygen consumption (CMRO2) was estimated based on measurements of arteriovenous (A-V) oxygen difference. Six cats were treated with naloxone 30 minutes after occlusion and 8 were treated 2 hours after occlusion. In 6 control animals, naloxone produced a 10-15% increase in mean arterial blood pressure (MABP), CBF and CMRO2 lasting 30 minutes. MCA occlusion reduced CBF by 70-75% in the ipsilateral MCA territory and by 15% in the contralateral hemisphere. Naloxone increased CBF by 3.5-6% in the ischemic region and 10-22% in the contralateral hemisphere in both treatment groups to the same extent as seen in control animals. There was no significant change in A-V oxygen difference and the estimated increase in CMRO2 of non-ischemic regions of both treatment groups was similar to that of control animals. These effects were transient and lasted 15-60 minutes. We have concluded that naloxone caused a transient increase in cerebral metabolism which equals or exceeds the corresponding increase in CBF. Therefore, naloxone would not be beneficial, and may be detrimental in the treatment of cerebral ischemia.
Detail-Preserving Contrast Reduction for Still Cameras (2006)

This paper describes a detail-preserving contrast reduction technique for images with excessive illumination variation. In an attempt to preserve detail, an image is first separated into its illumination and reflectance components, by a partial differential equation. The illumination component is then scaled to globally reduce contrast. This enhances the perception of detail in the dark areas but at the expense of losing detail in the bright areas. The proposed approach minimizes this loss of detail using a novel recombination strategy. Additionally, the present algorithm preserves colors, avoids halo artifacts, and can be embedded into existing still-camera pipelines.
Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry. (1978)

Two ionophores (monensin and gramicidin) that carry Na+ into 3T3 cells markedly enhance the rate of 86Rb+ uptake. Ouabain prevents both ionophores from increasing 86Rb+ uptake, indicating that the ionophores activate the Na+,K+ pump. Measurements of 86Rb+ uptake and cell Na+ and K+ over a range of monensin concentrations show that the activity of the Na+,K+ pump in 3T3 cells is limited by the supply of internal Na+ and is extremely sensitive to small changes in internal Na+. Serum rapidly enhances the rate of 22Na+ uptake and net Na+ entry when Na+ exit is inhibited by ouabain. At 0.3 microgram/ml, monensin increases the rate of net Na+ entry and activates the Na+,K+ pump by the same degree as serum. The stimulation of 86Rb+ uptake by serum or the ionophores has an absolute requirement for external Na+. Thus, serum appears to stimulate the Na+,K+ pump in quiescent 3T3 cells by increasing its supply of Na+.
Blebbistatin, a Myosin II Inhibitor, Exerts Antidepressant-Like Activity and Suppresses Detrusor Overactivity in an Animal Model of Depression Coexisting with Overactive Bladder (2018)

Overactive bladder (OAB) coexists with depression in women. Here, we assessed the effects of a 1-week treatment with blebbistatin, a myosin II inhibitor, on changes in behavior and detrusor overactivity (DO) symptoms induced by a 6-week administration of 13-cis-retinoic acid (13-cis-RA), with the aid of the forced swim test (FST), spontaneous locomotor activity test, and in vivo cystometric investigations in female Wistar rats. 13-cis-RA-induced depressive-like behavior and DO symptoms were associated with increased corticotropin-releasing factor (CRF) level in the plasma, prefrontal cortex (PFC), hippocampus (Hp), Barrington's nucleus (BN), and urinary bladder. Moreover, 13-cis-RA decreased brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in plasma, PFC, Hp, and BN, while it increased BDNF and NGF levels in urinary bladder. Blebbistatin exerted antidepressant-like effect and attenuated changes in the cystometric parameters as well as the central and peripheral levels of CRF, BDNF, and NGF that were induced by 13-cis-RA, while it did not affect urine production, mean, systolic or diastolic blood pressure, or heart rate. The results point to blebbistatin as a potential treatment option for OAB coexisting with depression.
A framework for automated association mining over multiple databases (2011)

Literature on association mining, the data mining methodology that investigates associations between items, has primarily focused on efficiently mining larger databases. The motivation for association mining is to use the rules obtained from historical data to influence future transactions. However, associations in transactional processes change significantly over time, implying that rules extracted for a given time interval may not be applicable for a later time interval. Hence, an analysis framework is necessary to identify how associations change over time. This paper presents such a framework, reports the implementation of the framework as a tool, and demonstrates the applicability of and the necessity for the framework through a case study in the domain of finance.
An electromigration model that includes the effects of microstructure and temperature on mass transport (1993)

A model for electromigration in thin metal film interconnects is presented that includes two components of diffusion. The grain-boundary and lattice components of mass transport are considered in terms of their temperature dependence and the metallurgical ‘‘structure’’ of patterned planar interconnects. Interconnect structure is defined in terms of single- and polycrystalline line segments, which result from the local grain microstructure for a patterned interconnect line. The dependence of the diffusional flux on the length and type of line segment is included in the model. The results indicate that the grain structure of the film plays an important role in determining the relative contribution of the diffusion components to mass transport. The model assumes that the length and type of interconnect line segment determines the relative contribution of grain boundary and lattice diffusion components, and provides a means for extrapolating accelerated test results for planar interconnects by taking into consideration the temperature dependence of the diffusion mechanisms, and the effect of the local microstructure on diffusion. The model also indicates that extrapolations made using Black’s equation may result in an overestimate of safe operating conditions. Calculations show that the effective activation energy depends on the median grain size and its distribution parameter, D50 and σ, respectively, and the interconnect linewidth W. Model calculations of electromigration lifetime t50 were compared to experimental results obtained on patterned interconnects using sputter-deposited Al-1.5% Cu alloy films. The experimental data support a linewidth-dependent electromigration activation energy and show that the dependence of t50 on linewidth for W≤3D50 results from a change in the dominant diffusion mechanism with temperature, linewidth, and local interconnect ‘‘structure.’’
IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells (2007)

IL-4 has distinct effects on the differentiation and functional properties of CD8+ T cells. In vivo studies have shown that it is critical for the development of protective memory responses against tumors and infections by Leishmania and Plasmodium parasites. The intracellular signaling events mediated by IL-4/IL-4 receptor (IL-4R) interactions on CD4+ T cells have been studied extensively; however, the nature of IL-4-induced signaling on CD8+ T cells has not been characterized. Using naïve, activated, as well as differentiated CD8+ T cells, we show that IL-4 has a strong in vivo and in vitro antiapoptotic effect on activated and resting CD8+ T cells. We demonstrate that IL-4 induces the phosphorylation of the IL-4R, which is followed by the activation of at least two distinct intracellular signaling cascades: the Jak1/STAT6 and the insulin receptor substrate/PI-3K/protein kinase B pathways. We also found that IL-4 induces the Jak3-mediated phosphorylation and nuclear migration of STAT1, STAT3, and STAT5 in naïve, activated, as well as differentiated, IFN-gamma-producing CD8+ T cells. The induction of this broad signaling activity in CD8+ T cells coincides with a transcriptional activity of suppressors of cytokine signaling genes, which are decreased significantly in comparison with CD4+ T cells. To our knowledge, this report constitutes the first comprehensive analysis of the signaling events that shape CD8+ T cell responses to IL-4.
Introduction to Phishing (2006)

This chapter contains sections titled: What is Phishing? A Brief History of Phishing The Costs to Society of Phishing A Typical Phishing Attack Evolution of Phishing Case Study: Phishing on Froogle Protecting Users from Phishing References