gebhart/patrepeval huggingface dataset:
Using signatures to improve URL routing (2003)

Devices which forward or route at layers higher than the IP layer are emerging to support growing World Wide Web content distribution networks (CDN). URL routing can be used to forward or redirect a client HTTP request to the nearest or otherwise best content source. We develop and evaluate a new look-up method that uses fixed-length URL signatures based on CRC32 coding of URL. The use of URL signatures results in smaller update messages, smaller routing tables, and faster lookups for URL routers. We show how the circuit used to generate an Ethernet packet CRC32 can be simultaneously used to generate the CRC32 of a URL within an HTTP request. We evaluate signature collisions, CPU resources needed to generate signature URL lists, URL list size, look-up performance, and TCP connection performance using nine representative server and cache traces. Signature collisions occur for a negligible number of URL. Signature-based URL lists consume ten times less memory and have look-up rates five to ten times faster than when using full-URL.
Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity (2004)

One of the mechanisms by which tumor cells evade the immune system is the lack of proper antigen-presenting cells. Improvement in host immunity against tumor cells can be achieved by promoting the differentiation of dendritic cells (DCs) from immature myeloid cells (Gr-1(+)Ly-6C(+)F4/80(+)) that accumulate in the bone marrow and lymphoid organs of mice with large tumor burdens. The enriched immature myeloid cells inhibit T-cell proliferation and tumor-specific T-cell response, which can be reversed by the differentiation of immature myeloid cells or depletion of F4/80(+) cells. Sorted Gr-1(+)/F4/80(+) immature myeloid cells differentiated into CD11c(+) cells that express CD80 and I-A/I-E (MHC class II) in the presence of recombinant murine granulocyte macrophage colony-stimulating factor (GM-CSF). Furthermore, intratumoral gene delivery of GM-CSF not only promoted the differentiation of carboxyfluoroscein succinimidyl ester-labeled immature myeloid cells into CD11c(+) cells with the characteristics of mature DCs (CD80(+), I-A/I-E(+)) but also enhanced innate natural killer and adaptive cytolytic T-cell activities in mice treated with interleukin (IL)-12 and anti-4-1BB combination therapy. More importantly, intratumoral delivery of GM-CSF and IL-12 genes in combination with 4-1BB costimulation greatly improved the long-term survival rate of mice bearing large tumors and eradicated the untreated existing hepatic tumor. The results suggest that inducing the maturation of immature myeloid cells, thus preventing their inhibitory activity and enhancing their antigen-presenting capability, by GM-CSF gene therapy is a critically important step in the development of effective antitumor responses in hosts with advanced tumors.
Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon o-quinones produced by dihydrodiol dehydrogenase (1996)

Eight polycyclic aromatic hydrocarbon (PAH) ortho-quinones that can be generated by dihydrodiol dehydrogenase (DD) were examined for their cytotoxicity in H-4-II-e (rat hepatoma) cells and for their mutagenicity in the Ames test. Seven of the PAH otrtho-quinones were potent cytotoxins yielding IC50 values for cell survival in the range 1-30 microns. PAH ortho-quinones were grouped into three classes based on their cytotoxicity profiles: group I contained ortho-quinones (e.g., naphthalene-1,2-dione and 7,12-dimethylbenz[alpha]anthracene-3,4-dione) which reduced cell viability and cell survival; group II contained ortho-quinones (e.g., benz[alpha]anthracene-3,4-dione and 5-methylchrysene-1,2-dione which reduced cell survival but had no effect on cell viability; and group III contained ortho-quinones (e.g., benzo[alpha]pyrene-7,8-dione) which had a pronounced effect on cell viability but minimal effects on cell survival. Using hepatoma cell suspensions and rat liver subcellular fractions, it was found that ortho-quinones underwent preferential enzymatic one-electron redox-cycling and produced superoxide anion radical (O2-.) and/or ortho-semiquinone anion or alternant radicals. ortho-Quinones that reduced cell viability produced O2-. and caused the most total free radical formation, while those that reduced cell survival produced ortho-semiquinone anion or alternant radicals only. PAH ortho-quinones were also tested as direct-acting mutagens in Salmonella typhimurium tester strains TA97a, TA98, TA100, TA102 and TA104. They were found to be more mutagenic than the test mutagens used for each tester strain, and were predominantly frameshift mutagens. The presence of an activating system (Aroclor-induced rat liver S9 plus NADPH) did not increase the mutagenicity of ortho-quinones in tester strains that are sensitive to oxidative mutagens (TA102 and TA104). These data suggest that PAH ortho-quinones produced by DD are cytotoxic and mutagenic by different mechanisms. The mechanism of cytotoxicity involves the formation of reactive oxygen species and/or ortho-semiquinone anion or alternant radicals. The mechanism of mutagenicity is independent of free radical formation and is related to the ability of PAH orthooffinones to intercalate and covalently modify DNA.
The pervasive trust foundation for security in next generation networks (2010)

We propose a new paradigm---named the Pervasive Trust Foundation (PTF) ---for computer security in Next Generation Networks, including the Future Internet. We start with a review of basic trust-related terms and concepts. We present motivation for using PTF as the basis for security in ISO OSI networks. The paper includes our five contributions. First, we define trust in the small (TIS) and trust in the large (TIL), where TIL is equivalent to PTF. Second, we list and contrast required and prohibited features of PTF-based systems. Third, we enumerate claims of benefits derived from using PTF. Fourth, we identify two major obstacles to PTF realization, and discuss multiple approaches to overcoming these obstacles. The more important of the two obstacles can be eliminated by showing an efficient implementation of PTF-based security. Fifth, we present an outline for the Basic Reference Model for PTF for Next Generation Networks. Summary and discussion of future work concludes the paper.
Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation (2006)

These data imply that dendrite maturation of immature neurons is initiated at varying times after cell cycle exit, is variable in duration, and is controlled independently of the regulation of precursor cell proliferation. We conclude that in addition to the major regulatory events in cell proliferation and selective survival, additional micro-regulatory events influence the course of adult hippocampal neurogenesis.
Human bone marrow allograft recipients: production of, and responsiveness to, interleukin 2. (1983)

The production and utilization of interleukin 2 (IL 2) by peripheral blood mononuclear cells (PBMC) from 14 bone marrow allograft recipients was examined. PBMC from all patients were impaired in their ability to produce IL 2 when stimulated by phytohemagglutinin (PHA). On the average, the IL 2 activity produced by patients' PBMC was 8% of that from normal donors' PBMC. To examine the basis for this impaired T cell function in marrow recipients, the ability of a resting T lymphocyte population isolated from PBMC to respond to PHA and exogenously supplied IL 2 was analyzed. The proliferative response of resting T cells to PHA and IL 2, although low at early times post-transplant, reached near normal levels by 8 mo. Only two of 11 patients had normal numbers of precursor T cells that could respond. For all other patients the average number of precursor T cells was 10-fold lower than the average determined for normal donors. The impaired production of IL 2 by patients' PBMC may be due to this low precursor frequency. For some patients the rate and/or extent of clonal expansion of activated T cells appears to be greater than that of normal donors. The data suggest that the therapeutic application of IL 2 to such patients is unlikely to be successful in overcoming defects of T cell function before 8 mo post-marrow transplant.
Formation, Thermal Stability and Mechanical Properties of Cu-Zr and Cu-Hf Binary Glassy Alloy Rods (2004)

Glassy alloy rods with diameters up to 1.5 mm exhibiting a large supercooled liquid region before crystallization and high mechanical strength were formed in Cu-Zr and Cu-Hf binary alloy systems by the copper mold casting method. The large supercooled liquid region exceeding 40 K was obtained in the composition range of 30 to 70 at%Zr and 35 to 60 at%Hf. The largest value of the supercooled liquid region defined by the difference between glass transition temperature (Tg) and crystallization temperature (Tx), ΔTx (= Tx − Tg), was 58 K for Cu60Zr40 and 59 K for Cu55Hf45. The reduced glass transition temperature (Tg/Tl) of the two alloys was 0.61 and 0.59, respectively. The alloys with large ΔTx above 50 K were formed into a bulk glassy alloy form with diameters up to 1.5 mm by copper mold casting. The Cu60Zr40, Cu45Zr55, Cu60Hf40 and Cu55Hf45 glassy alloy rods exhibited high fracture strength of 1920, 1880, 2245 and 2260 MPa, respectively, Young's modulus of 107, 102, 120 and 121 GPa, respectively, a nearly constant elastic elongation of about 1.9% and plastic elongation up to 2.2%. The formation of these binary glassy alloy rods can be interpreted in the framework of the concept of the formation of the unique glassy structure consisting mainly of icosahedral atomic configuration as similar to that for special multi-component alloys with the three component rules.
Development and analysis of electric field sensor using LiNbO/sub 3/ optical modulator (1992)

The sensitivity of an electromagnetic field sensor which uses a LiNbO/sub 3/ electrooptical crystal and an optical-fiber link is improved by using a Mach-Zehnder interferometer, whose half-wave voltage is about 4 V at 1.3- mu m wavelength, and a YAG laser pumped by a laser diode whose output power is 25 mW. The resulting frequency response is about flat from 100 Hz to 300 MHz, and the minimum detectable electric field strengths are 0.22 mV/m at 50 MHz and 0.079 mV/m at 750 MHz. The variation of the sensitivity with the frequency and element length are analyzed using the moment method, and the calculated results agree with the measured results. The measurement of the cross-polarization of the sensor indicates that this property is similar to that of a dipole antenna. The improved sensor can measure an electromagnetic impulse whose peak value is larger than 10 V/m and whose width is wider than 5 ns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optic Neuropathy and Chronic Cyanide Intoxication: A Review (1988)

Keywords tobacco use disorder, optic neuropathy, cyanide neurotoxicity, anaemia, pernicious, hydroxocobalamin
Performance of a Simulated Dataflow Computer (1980)

Our goal is to devise a computer comprising large numbers of cooperating processors (LSI). In doing so we reject the sequential and memory cell semantics of the von Neumann model, and instead adopt the asynchronous and functional semantics of dataflow. We briefly describe the high-level dataflow programming language Id, as well as an initial design for a dataflow machine and the results of detailed deterministic simulation experiments on a part of that machine. For example, we show that a dataflow machine can automatically unfold the nested loops of n X n matrix multiply to reduce its time complexity from 0(n3) to 0(n) so long as sufficient processors and communication capacity is available. Similarly, quicksort executes with average 0(n) time demanding 0(n) processors. Also discussed are the use of processor and communication time complexity analysis and "flow analysis," as aids in understanding the behavior of the machine.
Development of Novel CBN Cutting Tool for High Speed Machining of Inconel 718 Focusing on Coolant Behaviors (2017)

Nickel-based superalloys such as Inconel 718 are known as one of the most difficult-to-cut materials due to their mechanical and chemical properties and the tool life is extremely short. Recently, Cubic-Boron-Nitride (CBN) has received considerable attention as a material for cutting tools and has already established itself in many areas of machining. However, the performance of CBN tools is still insufficient in practical use, especially in the high speed machining of Inconel 718. To overcome this problem, cutting experiments on Inconel 718 at a wide range of cutting speeds (100 m/min - 500 m/min) were conducted and the performance of CBN cutting tools under dry and wet cutting conditions was evaluated. Based on the result, we newly developed a CBN cutting tool with a textured flank face with the aim to enhance the effect of cutting fluid at the tool-workpiece interface. Experimental results showed that the textured flank face improved the wear resistance of the CBN cutting tool in the high speed machining of Inconel 718.
Balancing the Benefits and Risks of Drug Treatment (2007)

This study shows that treatment attributes influence patients with psoriasis in their choice of treatment. The results of the discrete choice experiment presented herein indicate that most respondents would be willing to trade between different aspects of treatment to achieve improvements in their psoriasis and minimize the risks of adverse events.
Cyclin-dependent Kinase 5 in Lewy Body-like Inclusions in Anterior Horn Cells of a Patient with Sporadic Amyotrophic Lateral Sclerosis (1997)

Lewy body-like inclusion (LI) is a cytoplasmic inclusion body deposited in anterior horn cells of patients with amyotrophic lateral sclerosis (ALS), in which there are phosphorylated neurofilament proteins (NFP). Since phosphorylation of NFP occurs normally in the axon, aberrant phosphorylation of NFP should take place in these cell bodies. To clarify the mechanism of LI formation it is crucial to identify the kinase responsible for the phosphorylation. We found cyclin-dependent kinase 5 (cdk5) immunoreactivity in most of LI in an ALS patient. Since cdk5 phosphorylates NFP, cdk5 is a candidate kinase for NFP in LI and might be involved in the cytoskeletal disorganization in LI-containing neurons.
Spastic hypertonia: mechanisms and measurement. (1989)

Spastic hypertonia has been defined as a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyperexcitability of the stretch reflex, as one component of the upper motor neuron syndrome. Heightened muscle tone may be the result of changes intrinsic to the muscle or to altered reflex properties. Increased motoneuronal excitability and/or enhanced stretch-evoked synaptic excitation of motoneurons are mechanisms that might enhance stretch reflexes. Two distinct parameters may be altered in the pathologic stretch reflex--the "set point," or angular threshold of the stretch reflex, and the reflex "gain," or the amount of force required to extend the limb in proportion to the increasing joint angle. Earlier studies fail to dissociate the contributions of reflex threshold and reflex gain. Recent investigations suggest that spastic hypertonia may be the result of a decrease in stretch reflex threshold without significant increase in reflex gain, as was previously believed. Various clinical scales, biomechanical paradigms, pendulum models, and electrophysiologic studies have been used to quantify spastic hypertonia. Biomechanical methods seem to correlate most closely with the clinical state. Spastic hypertonia is but one component of the upper motor neuron syndrome, whose features also include loss of dexterity, weakness, fatigability, and various reflex release phenomena. These other features of the upper motor neuron syndrome may well be more disabling to the patient than changes in muscle tone.
Efficient Vanadium‐Catalyzed Aerobic C−C Bond Oxidative Cleavage of Vicinal Diols (2018)

Abstract The aerobic oxidative C−C bond cleavage of vicinal diols catalyzed by vanadium amino triphenolates is described. Our results show that C−C bond cleavage can be performed in different solvents, under an air or oxygen atmosphere, with a large variety of glycols (cyclic or linear, with aromatic or aliphatic substituents) affording the corresponding carbonyl derivatives with high chemoselectivity. Reactions can be performed with as little as 10 ppm of catalyst reaching TON up to 81,000 and TOFs of up to 4150 h −1 . A reaction mechanism, rationalized by density functional theory calculations, is also proposed. magnified image
Histone Deacetylase Inhibitors Induce Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells (2012)

Clinical experience of histone deacetylase inhibitors (HDACIs) in patients with solid tumors has been disappointing; however, the molecular mechanism of treatment failure is not known. Therefore, we sought to investigate the molecular mechanism of treatment failure of HDACIs in the present study. We found that HDACIs Trichostatin A (TSA) and Suberoylanilide hydroxamic acid (SAHA) could induce epithelial-to-mesenchymal transition (EMT) phenotype in prostate cancer (PCa) cells, which was associated with changes in cellular morphology consistent with increased expression of transcription factors ZEB1, ZEB2 and Slug, and mesenchymal markers such as vimentin, N-cadherin and Fibronectin. CHIP assay showed acetylation of histone 3 on proximal promoters of selected genes, which was in part responsible for increased expression of EMT markers. Moreover, TSA treatment led to further increase in the expression of Sox2 and Nanog in PCa cells with EMT phenotype, which was associated with cancer stem-like cell (CSLC) characteristics consistent with increased cell motility. Our results suggest that HDACIs alone would lead to tumor aggressiveness, and thus strategies for reverting EMT-phenotype to mesenchymal-to-epithelial transition (MET) phenotype or the reversal of CSLC characteristics prior to the use of HDACIs would be beneficial to realize the value of HDACIs for the treatment of solid tumors especially PCa.
On the Field-Induced Cholesteric-Nematic Transition in Cholesteric Liquid Crystals with Homeotropic Boundary Conditions (1983)

Abstract The influence of homeotropic boundary conditions on the cholesteric-nematic transition is discussed, starting from the assumption that the director field consists of only components perpendicular to the helix axis, which is directed parallel to the boundary planes. Attention is paid to the solution of Cladis and Kléman for the simpler case without magnetic field. Their solution, consisting of regularly spaced line signularities, is derived in another more transparent way. Besides it is shown that even director fields without singularities are possible. The presence of a magnetic field complicates the solution considerably. Now the relevant Euler-Lagrange equation is solved in an approximate way by partly resorting to the difference method. The usefulness of the method is demonstrated by applying this technique to the nematic-cholesteric transition and the Fréedericksz transition in nematics.
Inhibitory effects of flavonol glycosides on 12-O-Tetradecanoylphorbol-13-acetate-induced tumor promotion. (1990)

The two-stage carcinogenesis by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate (TPA) in mice was inhibited by kaempferol and flavonol glycosides, whereas naringenin, a flavanone, had no effect. The induction of epidermal ornithine decarboxylase activity by TPA was also inhibited by kaempferol, whereas mauritianin, a kaempferol glycoside, failed to inhibit it. In addition, the effect of the flavonol glycosides on cell-mediated immunosuppression in the two-stage carcinogenesis, observed in terms of initiation after 14 weeks, was antagonized by mauritianin and myricitrin. Cell-mediated immunosuppression in the two-stage carcinogenesis was unaffected by kaempferol and naringenin. These results suggest that the inhibitory effects of flavonol glycosides may have been at least partly due to activation of immune responses against tumors.
Upper Limit of Vulnerability Predicts Chronic Defibrillation Threshold for Transvenous Implantable Defibrillators (1997)

The strength of the correlation between the chronic ULV and the chronic DFT is comparable to that between the acute ULV and the acute DFT. Temporal changes in the ULV predict temporal changes in the DFT. In clinically stable patients, a defibrillation safety margin of 3 J above the acute ULV proved an adequate chronic safety margin.
Eine Methode zur In‐vitro‐Selektion ohne eingeschobene Amplifikationsschritte (1997)

Schrittweises Screening ohne enzymatische Amplifikation gelingt an DNA‐Aptameren für ATP; damit wurde gezeigt, daß die In‐vitro‐Selektion von kombinatorischen Oligonucleotidbibliotheken ohne zwischengeschaltete Polymeraseschritte möglich ist. Das Verfahren ist rechts schematisch dargestellt. magnified image
Optical Detection of Macromolecular Heparin via Selective Coextraction into Thin Polymeric Films (1995)

Thin plasticized polymer films, poly(vinyl chloride) doped with a specific ion pairing quaternary ammonium compound, tridodecylmethylammonium chloride, and a lipophilic pH indicator, 3-hydroxy-4-(4-nitrophenylazo)phenyl octadeconate, are shown to exhibit significant and analytically useful optical response toward macromolecular heparin. The response mechanism is based on favorable extraction of heparin into the bulk organic film, owing to the specific ion-pairing complexation reaction between the quaternary ammonium species and the polyanion. A simultaneous coextraction of hydrogen ions results in protonation of the pH chromophore and hence a change in the optical absorbance of the polymeric film. When used in a limited volume/fixed exposure (10 min) detection mode, film absorbances change as a function of the initial heparin concentration in the range of 0.2-3.0 units/mL (1.2-18 micrograms/mL). The practical measurement response time is controlled by heparin diffusion through the stagnant diffusion layer adjacent to the surface of the film as well as within the bulk of the polymer film and is shown to increase with the molecular weight of the heparin species tested. No optical response to heparin is observed when a strong heparin complexing agent (e.g., protamine) is present in the test solution, suggesting that the polymer film can be used to conveniently monitor heparin-protamine (or other antagonist) titrations. The theory relating to the operation of the sensing film in either the equilibrium or the kinetic mode and the selectivity of the optimized film to heparin relative to small anions are presented.
Wissenschaft als Beruf: Ein uneingelöstes Vermächtnis seit 1848 (2011)

Wissenschaft als normaler Beruf – diese Forderung stellt die Gewerkschaft Erziehung und Wissenschaft in ihrem Templiner Manifest. Diese wurde auf der 4. GEW-Wissenschaftskonferenz im September 2010 entwickelt und spitzt die Forderungen zu Reformen der Personalstruktur in zehn Punkten zu. Dabei wird deutlich, dass die fehlende Planbarkeit und die fehlende Absicherung zentrale Probleme sind. Diese Probleme sind jedoch keinesfalls neu, sondern können auf eine lange Tradition im deutschen Wissenschaftssystem zurückgreifen. … [Der Autor zeichnet] die auch historisch gewachsenen Ursachen für die wichtigsten Probleme der Beschäftigungsstruktur in der Wissenschaft nach. Dabei benennt er Anforderungen an eine Reform von Personalstruktur und Berufswegen in Hochschule und Forschung. (DIPF/Orig.)