gebhart/patrepeval huggingface dataset:
Stuttering treated with olanzapine: a case report. (2012)

Spasmophemia, also called stuttering or stammering, is a speech disorder characterized by impairment of the rhythm of words whose classical symptoms are blocks and repetitions.We describe the case of a male patient, his evolution and therapeutic strategies and review the current literature on the subject.A 33-year-old patient was referred to our Mental Health Unit by his family doctor due to “speech problems and difficulty expressing ideas. His symptoms had worsened in recent weeks, with increase in his state of anxiety.” Standing out in the consultation to the doctor, the patient experienced multiple blocks in expressing words, using circumlocutions and monosyllabic repetitions that made it very difficult to conduct the interview. Anticipatory anxiety and occasional obsessions of repeated checking also stand out. After six weeks of treatment with olanzapine 5 mg/daily, the patient showed significant improvement both in the fluency and anticipatory anxiety with decreased repetitions, blocking, interjections and broken words.Spasmophemia has been associated with dopaminergic hyperactivity, so that studies have been conducted with atypical antipsychotics. Fundamentally, olanzapine and risperidone have revealed promising results. Furthermore, several studies have shown that these patients have higher rates of anxiety. That is why antidepressants and antianxiety drugs such as clomipramine, paroxetine, fluoxetine, citalopram, sertraline and alprazolam have been used.Treatment with olanzapine, 5HT-2 and D1/ D2 antagonist, significantly improved the clinical picture as Boyd et al. have described in their systematic review.
Draco: Statistical diagnosis of chronic problems in large distributed systems (2012)

Chronics are recurrent problems that often fly under the radar of operations teams because they do not affect enough users or service invocations to set off alarm thresholds. In contrast with major outages that are rare, often have a single cause, and as a result are relatively easy to detect and diagnose quickly, chronic problems are elusive because they are often triggered by complex conditions, persist in a system for days or weeks, and coexist with other problems active at the same time. In this paper, we present Draco, a scalable engine to diagnose chronics that addresses these issues by using a “top-down” approach that starts by heuristically identifying user interactions that are likely to have failed, e.g., dropped calls, and drills down to identify groups of properties that best explain the difference between failed and successful interactions by using a scalable Bayesian learner. We have deployed Draco in production for the VoIP operations of a major ISP. In addition to providing examples of chronics that Draco has helped identify, we show via a comprehensive evaluation on production data that Draco provided 97% coverage, had fewer than 4% false positives, and outperformed state-of-the-art diagnostic techniques by up to 56% for complex chronics.
The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta‐analysis (2018)

HNS is a safe and effective treatment for CPAP refractory OSA. Further study comparing HNS to other therapies is required.
Oligonucleotide Synthesis Involving Deprotection of Amidine-Type Protecting Groups for Nucleobases under Acidic Conditions (2010)

Amidine-type protecting groups, i.e., N,N-dimethylformamidine (dmf) and N,N-dibutylformamidine (dbf) groups, introduced into nucleobases were rapidly removed under mild acidic conditions using imidazolium triflate (IMT) or 1-hydroxybenztriazole (HOBt). This new deprotection strategy allowed a 2'-O-methyl-RNA derivative bearing a base-labile group to be efficiently synthesized using a silyl-type linker. It was also found that our new method could be applied to the synthesis of an unmodified RNA oligomer.
Increase in arginine and citrulline production by 6-azauracil-resistant mutants of Bacillus subtilis (1977)

In the arginine producer AHr-5, an L-arginine hydroxamate-resistant mutant of Bacillus subtilis, accumulation of N8-acetyl-L-ornithine increased as the level of L-arginine accumulation increased in the medium containing L-glutamic acid. Ornithine carbamoyltransferase of this strain was genetically derepressed. These results suggested that carbamoylphosphate might be deficient in vivo. With the intention to increase endogenous carbamoylphosphate, pyrimidine analogs inhibiting growth were selected and the mutants resistant to these compounds were derived from the AHr-5 mutant. Of the resistant mutants derived, the 6-azauracil-resistant mutant AAr-9 produced 28 mg of L-arginine per ml, which corresponded to more than twofold the amount produced by the parent strain. Derivation of an arginine-requiring mutant from the double-resistant mutant AAr-9 provides a new advantageous method for the production of L-citrulline. The increase in arginine and citrulline production is discussed.
Ultrasonic pulsed beam interaction with a fluid-loaded elastic plate: Theory (1996)

The interaction of transducer-excited ultrasonic pulsed beams with fluid-loaded elastic plates is treated with a computationally efficient analytical model. The model synthesizes the frequency-domain voltage, due to a single transducer operated in reflection (pulse-echo) mode and a pair of tranducers in transmission mode, utilizing an approach that is based on (1) expansion of transducer fields in terms of quasi-Gaussian beams modeled via the complex-source-point technique and its recent extension to finite receivers, and on (2) complex wave-number spectral decomposition and synthesis to solve the beam–structure interaction problem. First, a reference solution for the frequency-domain reflected and transmitted fields is expressed in terms of spectral integrals over two-dimensional infinite spectra of plane waves weighted by the plate reflection or transmission coefficient. Subsequent expansion in terms of a finite sum of integrals representing multiply reflected beams propagating within the plate, combined with high-frequency asymptotics and inverse Fourier transformation of the frequency-domain data, yields the time-domain voltage as a finite sum of purely compressional (P), purely shear (S), and P–S coupled arrivals. Of particular interest is the new higher-order asymptotic expansion developed to account for shear waves excited in the plate by the finite angular spectrum of beams at normal incidence. Both reference and asymptotic solutions have been implemented in numerical codes and validated against experimentally generated data. This is shown in a follow-up paper. The methodology presented here can be applied under more general conditions of transducer orientation and focusing, and also for elastic media with more than one layer.
Fast Ray-Tetrahedron Intersection Using Plucker Coordinates (2003)

Abstract We present an algorithm for ray-tetrahedron intersection. The algorithm uses Pliicker coordinates to represent the ray and the edges of the tetrahedron and employs a rob ust and efficient test to determine the intersection. The algorithm is highly optimized and provides a significant performance increase over related algorithms. Source code is available online.
Time required to change yearling steers from roughage to high grain ration; using Stilbestrol as an implant and in the feed; worming yearling steers (2011)

Sixty yearling steers were removed from bluestem pasture October29, 1965 and trucked six miles to the KSU beef cattle research barn where they received prairie hay and had access to a self-feeder of 50% bran and 50% dry rolled sorghum grain. October 30 they were weighed and divided into three lots of 20 steers.
Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of cadaveric spines. (1995)

Angiograms were made of twenty-two cadaveric lumbar spines to determine the presence of any new blood vessels between adjacent lumbar vertebrae and corresponding discs. The annulus and adjacent longitudinal ligaments were also analyzed histologically. A total of 105 intervertebral spaces were studied. It was found that the normal anastomosing arteries in the posterior longitudinal ligament were significantly obliterated with advancing degeneration of the disc (p < 0.001), whereas several tiny tortuous arteries--often running between the osteophytic spurs--were seen in the anterolateral aspects of the intervertebral spaces connecting the adjacent vertebrae. Histological examination of the anterolateral part of the annulus showed that the vascularity of the annulus increased significantly with degeneration of the disc (p < 0.001), and most of the arteries had a vertical orientation. Regression analysis showed that vascular changes occurred before degeneration of the disc at every lumbar level, suggesting that disturbances in the nutritional supply may precede degeneration. The correlation coefficient was 0.77 (95 per cent confidence limit, 0.52 to 0.90) for the increase in annular vascularity with an increase in the age of the individual at the time of death and 0.86 (95 per cent confidence limit, 0.69 to 0.94) for the increase in degeneration of the disc with an increase in age.
A novel polymer produced by a bacterium isolated from a deep-sea hydrothermal vent polychaete annelid (2002)

Due to its interesting biological activities, applications have been found in cosmetics. Its probable contribution to the filamentous microbial mat in the Alvinella pompejana microenvironment can be also mentioned.
3-D preserved amplitude prestack depth migration on a workstation (1999)

Abstract We present an algorithm based on the ray-Born approximation for 3-D preserved amplitude prestack depth migration (PAPsDM) of seismic reflection data. This ray+Born inversion scheme allows the quantitative recovery of model perturbations. The Green's functions are estimated by dynamic ray tracing in 3-D heterogeneous smooth velocity fields with a wavefront construction (WFC) method. The PAPsDM algorithm was implemented on a single-processor Sun SPARC 20 workstation. Special attention was paid to CPU efficiency and memory requirements. We present an application on a 3-D real marine data set (13 Gbytes). About one week of CPU time is needed to obtain a migrated image of 7X1X1 km.
The Basis for, and Advantages of, Bayesian Model Estimation via Repeated Sampling (2003)

This chapter contains sections titled: Introduction Gibbs Sampling Simulating Random Variables from Standard Densities Monitoring MCMC Chains and Assessing Convergence Model Assessment and Sensitivity Review References
Point Sources in the Context of Future SZ Surveys (2004)

We look at the impact of Infra-Red (IR) and radio point sources on upcoming large yield Sunyaev-Zel'dovich (SZ) cluster surveys such as APEX, SPT and ACT. The IR and radio point source counts are based on observations by the the SCUBA and WMAP instruments respectively. We show that the contributions from IR source counts, when extrapolated from the SCUBA frequency of 350GHz to the operating frequencies of these surveys (~100-300GHz), can be a significant source of additional `noise' which needs to be accounted for in order to extract the optimal science from these surveys. Alternatively, these surveys give us an opportunity to study IR sources, their numbers and clustering properties, opening a new window to the high redshift universe. For the radio point sources, the contribution depends on a more uncertain extrapolation from 40GHz but is comparable to the IR near 200GHz. However, the radio signal may be correlated with clusters of galaxies and have a disproportionately larger effect.
Role of Telematics In Motor Insurance: A Way forward (2021)

Telematics or Usage Based Insurance (UBI) is one of the fastest growing concepts in the motor insurance segment. In India, traditional risk rating methods are still used, which are not capable of analysing the risk accurately and telematics can help to solve this issue. India is far behind other countries, which use telematics. This paper seeks to study the Role of Telematics in Motor Insurance and the perception of customers towards it. Further, the way forward for this technology is also discussed. For this research, the benefits and shortcomings of telematics have been analysed. Also, a survey was conducted and respondent�??s opinion as to the installation/ usage of telematics device was asked. A Logistic Regression test was then done to complete our analysis. The findings present that most of the people in India are willing to have telematics devices installed if their privacy concerns are taken care of.
The accuracy and precision of estimating tissue displacements from ultrasonic images (2003)

In many medical ultrasound imaging systems, clinical data are often presented in the form of tissue displacement and tissue velocity maps. The accuracy of tissue displacement estimates obtained using a well-established cross-correlation, speckle tracking technique is determined. The accuracy of the cross-correlation technique is evaluated as function of three parameters: (1) the magnitude of the tissue displacement; (2) the size of the region being tracked; and (3) of host tissue type. Three different sample types (porcine liver, porcine muscle and woolen sea sponge) are used to study the effect of different scattering media on displacement estimates. For identically sized target regions and displacements, liver samples produce estimates with the largest uncertainties. For all three sample types, the accuracy and precision of displacement estimates deteriorates with increasing sample displacements and decreasing target dimensions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CYSTOSCOPIC FINDINGS CONSISTENT WITH INTERSTITIAL CYSTITIS IN NORMAL WOMEN UNDERGOING TUBAL LIGATION (1998)

Bladder mucosal lesions characteristically associated with irritative voiding symptoms and pelvic pain in patients diagnosed with interstitial cystitis were observed in asymptomatic women.
Physics of Graphene (2008)

A brief review is given on exotic electronic and transport properties of monolayer graphene from a theoretical point of view.
Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma (2010)

Background Proliferation of malignant plasma cells is a strong adverse prognostic factor in multiple myeloma and simultaneously targetable by available (e.g. tubulin polymerase inhibitors) and upcoming (e.g. aurora kinase inhibitors) compounds.Design and Methods We assessed proliferation using gene expression-based indices in 757 samples including independent cohorts of 298 and 345 samples of CD138-purified myeloma cells from previously untreated patients undergoing high-dose chemotherapy, together with clinical prognostic factors, chromosomal aberrations, and gene expression-based high-risk scores.Results In the two cohorts, 43.3% and 39.4% of the myeloma cell samples showed a proliferation index above the median plus three standard deviations of normal bone marrow plasma cells. Malignant plasma cells of patients in advanced stages or those harboring disease progression-associated gain of 1q21 or deletion of 13q14.3 showed significantly higher proliferation indices; patients with gain of chromosome 9, 15 or 19 (hyperdiploid samples) had significantly lower proliferation indices. Proliferation correlated with the presence of chromosomal aberrations in metaphase cytogenetics. It was significantly predictive for event-free and overall survival in both cohorts, allowed highly predictive risk stratification (e.g. event-free survival 12.7 versus 26.2 versus 40.6 months, P
A Surgeless Solid-State DC Circuit Breaker for Voltage-Source-Converter-Based HVDC Systems (2014)

This paper proposes a dc circuit breaker for voltage source converter (VSC) based high-voltage dc transmission (HVDC) systems. Technical challenges for applying dc circuit breakers are to increase blocking voltage and to suppress surge voltage at the current clearing. The proposed dc circuit breaker is a solid-state breaker which consists of a number of semiconductor devices in series. It maintains equal voltage balancing among the devices to apply it to high-voltage applications. Moreover, the surge voltage across the circuit breaker is reduced by employing a freewheeling diode. Considering a system rated at 300 MW in power and 250 kV in dc voltage, the conduction loss of the proposed circuit breaker is estimated to be 0.045% of the rated power. The value is smaller than the power loss of the VSCs. A downscaled HVDC system rated at 10 kW in power and 360 V in dc voltage was built and tested. A series of experimental results demonstrates the dc fault clearing and rapid restoration of power transmission.
GPS Receiver Architecture and Expected Performance for Autonomous Navigation in High Earth Orbits (2000)

ABSTRACT: GPS is an enabling technology for autonomous spacecraft navigation, including mission concepts involving formation flying in highly eccentric orbits. However, to date most spaceborne GPS applications have been limited to low earth orbits or postprocessing applications. This paper describes the problems associated with using GPS in the high earth orbit (HEO) environment and presents a GPS receiver design optimized for these applications. The design builds upon the PiVoT receiver developed by Goddard Space Flight Center by incorporating the GPS Enhanced Orbit Determination (GEODE) navigation filter, a high-quality clock, and enhancements to basic receiver acquisition and tracking algorithms. Predicted navigation performance for several representative missions, including geosynchronous and geosynchronous transfer orbits, is presented. The analysis shows that a modest reduction in the acquisition threshold of the receiver enables reliable navigation performance even in very high orbits with unfavorable antenna placement restrictions.
THE ETHNIC OWNERSHIP ECONOMY (2004)

The literature of ethnic ownership economies descends from middleman minority theory, a subject it continues to include. However, ethnic economy literature now more broadly addresses the economic independence of immigrants and ethnic minorities in general, not just of middleman minorities (Light & Bonacich, 1991, pp. xii–xiii).1 This expansion releases the subject from narrow concentration upon historical trading minorities, and opens discussion of the entire range of immigrant and ethnic minority strategies for economic self-help and self-defense. Partial or full economic independence represents a ubiquitous self-defense of immigrants and ethnic minorities who confront exclusion or disadvantage in labor markets. Ethnic economies permit immigrants and ethnic minorities to reduce disadvantage and exclusion, negotiating the terms of their participation in the general labor market from a position of greater strength. Unable to find work in the general labor market, or unwilling to accept the work that the general labor market offers, or just reluctant to mix with foreigners, immigrants and ethnic minorities have the option of employment or self-employment in the ethnic economy of their group. Although ethnic and immigrant groups differ in how well and how much they avail themselves of this defense (Collins, 2003; Light & Gold, 2000, p. 34; Logan & Alba, 1999, p. 179), none lacks an ethnic economy.2
Integrated high frequency low-noise current-mode optical transimpedance preamplifiers: theory and practice (1995)

Classical designs of optical transimpedance amplifiers for p-i-n photodiode receiver circuits generally employ common-emitter or common-source input stages. In this paper we explore the design of a new class of low noise "current-mode" optical transimpedance preamplifier based upon common-base input stages. Simulated and measured results of a 10 GHz GaAs HBT and 3.5 GHz BiCMOS common-base input optical transimpedance amplifier are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
FT-IR-Kartierung – ein neues Werkzeug zur ortsaufgelösten Charakterisierung von polymergebundenen kombinatorischen Verbindungsbibliotheken mit IR-Mikroskopie (1998)

Das IR-spektroskopische Abrastern von Harzbeads ermöglicht eine zerstörungsfreie Charakterisierung von polymergebundenen kombinatorischen Verbindungsbibliotheken. Durch Wahl unterschiedlicher Absorptionen zur IR-Darstellung lassen sich Harzbeads mit gemeinsamen Strukturelementen aus einer Bibliothek „herausfischen”︁ und statistisch auswerten.
Selective reduction of heart rate by ivabradine (2004)

In WKY rats and SHR, acute ivabradine reduces MBP and DBP and increases pulse pressure, but without change in arterial stiffness. In both strains, the HR reduction due to ivabradine induces an identical increase of the energy dissipation of the arterial wall.
The role of gut microbiota in programming the immune phenotype (2013)

The human fetus lives in a germ-free intrauterine environment and enters the outside world containing microorganisms from several sources, resulting in gut colonization. Full-term, vaginally born infants are completely colonized with a diverse array of bacterial families in clusters (Phyla) and species (>1000) by the first year of life. Colonizing bacteria communicating with the gut epithelium and underlying lymphoid tissues ('bacterial-epithelial crosstalk') result in a functional immune phenotype and no expression of disease (immune homeostasis). Appropriate colonization is influenced by the prebiotic effect of breast milk oligosaccharides. Adequate colonization results in an innate and adaptive mucosal immune phenotype via communication between molecular patterns on colonizing bacteria and pattern-recognition receptors (e.g., toll-like receptors) on epithelial and lymphoid cells. This ontogeny affects the immune system's capacity to develop oral tolerance to innocuous bacteria and benign antigens. Inadequate intestinal colonization with premature delivery, delivery by Cesarean section and excessive use of perinatal antibiotics results in the absence of adequate bacterial-epithelial crosstalk and an increased incidence of immune-mediated diseases [e.g., asthma, allergy in general and necrotizing enterocolitis (NEC)]. Fortunately, infants with inadequate intestinal colonization can be restored to a bacterial balance with the intake of probiotics. This has been shown to prevent debilitating diseases such as NEC. Thus, understanding the role of gut microbiota in programming of the immune phenotype may be important in preventing disease expression in later childhood and adulthood.
Colloidal Synthesis of InSb Nanocrystals with Controlled Polymorphism Using Indium and Antimony Amides (2013)

We report a new synthetic pathway for growing monodisperse colloidal indium antimonide nanocrystals. We propose that highly reactive element-nitrogen bonded precursors, such as In and Sb amides, may provide required nucleation and growth kinetics for the formation of uniform colloidal nanocrystals of InSb. Size-dependent absorption and emission spectra of InSb nanocrystals in the near-infrared region of 1500–2000 nm point to semiconductor behavior with quantum confinement. Furthermore, we demonstrate zinc blende/wurzite polymorphism and polytypism of InSb nanocrystals, conveniently controlled by the In/Sb molar ratio of precursors. This amide-based synthesis route may open new opportunities for designing near- and mid-IR active III–V semiconductor nanostructures.