gebhart/patrepeval huggingface dataset:
Integrating GPS/INS and adaptive monopulse MUSIC for position location (2002)

Radar position estimation from target signals suffers from main-beam jamming. One way to counteract the problem is to integrate data from multiple sensors. An adaptive monopulse Multiple Signal Classification (MUSIC) algorithm discerns the azimuth and elevation angle estimation or true spectrum amongst jamming, but relying solely on the algorithm results in an undesirable position location and navigation error. By integrating the azimuth and elevation signals from an Integrated Navigational System (INS) with monopulse radar and referencing the position to a Global Positioning System (GPS) receiver, accurate positional location results. The paper describes a locating algorithm designed for navigation by integrating sensor signals from a GPS receiver for position estimation, an INS system,which has repeated measurement location updates from a ground-based target, and a four-aperture monopulse radar, which adaptively reduces main-beam jamming from the MUSIC algorithm for reliable angle estimation The results show that the sensor integration algorithm effectively and efficiently identifies the correct positional information.
Prostate cancer: US-guided percutaneous cryoablation. Work in progress. (1995)

These preliminary results demonstrate that cryosurgery can cause necrosis of prostate cancer. Long-term results and randomized trials are necessary to determine if this means longer disease-free intervals and increased patient survival compared with results of current therapeutic methods.
Aberrant Function of the Ras-Related Protein TC21/R-Ras2 Triggers Malignant Transformation (1994)

Although the human Ras proteins are members of a large superfamily of Ras-related proteins, to date, only the proteins encoded by the three mammalian ras genes have been found to possess oncogenic potential. Among the known Ras-related proteins, TC21/R-Ras2 exhibits the most significant amino acid identity (55%) to Ras proteins. We have generated mutant forms of TC21 that possess amino acid substitutions analogous to those that activate Ras oncogenic potential [designated TC21(22V) and TC21(71L)] and compared the biological properties of TC21 with those of Ras proteins in NIH 3T3 and Rat-1 transformation assays. Whereas wild-type TC21 did not show any transforming potential in vitro, both TC21(22V) and TC21(71L) displayed surprisingly potent transforming activities that were comparable to the strong transforming activity of oncogenic Ras proteins. Like Ras-transformed cells, NIH 3T3 cells expressing mutant TC21 proteins formed foci of morphologically transformed cells in monolayer cultures, proliferated in low serum, formed colonies in soft agar, and developed progressive tumors in nude mice. Thus, TC21 is the first Ras-related protein to exhibit potent transforming activity equivalent to that of Ras. Furthermore, mutant TC21 proteins also stimulated constitutive activation of mitogen-activated protein kinases as well as transcriptional activation from Ras-responsive promoter elements (Ets/AP-1 and NF-kappa B). We conclude that aberrant TC21 function may trigger cellular transformation via a signal transduction pathway similar to that of oncogenic Ras and suggest that deregulated TC21 activity may contribute significantly to human oncogenesis.
Influenza A Virus-Binding Activity of Glycoglycerolipids of Aquatic Bacteria (2000)

As the aqueous sphere has been proposed to be an important source medium for the virus infection of land animals, the glycolipids of some aquatic organisms were examined for human influenza A virus-binding activity. Active compounds were not found among the eight echinoderm gangliosides, but two active non-sialylated glycoglycerolipids were isolated from an aquatic bacterium, Corynebacterium aquaticum. The structural formula of one of them, H632A, was elucidated to be 1-14-methyl-hexadecanoyl-3-alpha-D-galactopyranosyl-(1-->3)-6-(12-met hyl-tetradecanoyl)-1-alpha-D-mannopyranosyl]-sn-glycerol. The latter together with reported one elsewhere, S365A, 1-14-methyl-hexadecanoyl-3-[alpha-D-mannopyranosyl-(1-->3)-6-(12-meth yl-tetradecanoyl)-1-alpha-D-mannopyranosyl]-sn-glycerol, apparently bound to three human influenza viruses, A/PR/8/34 (H1N1), A/Aichi/2/68 (H3N2), and A/Memphis/1/71 (H3N2), exhibiting 7-12% (H632A) and 10-22% (S365A) of the activities of the control substances (Neu5Acalpha2-3-paragloboside and Neu5Acalpha2-6- paragloboside). Additionally, these glycolipids were assumed to have virus-neutralizing activities for the following two reasons: (i) The hemagglutination and hemolysis activities of the viruses were inhibited by the glycolipid. (ii) The leakage of a cytosolic enzyme (lactate dehydrogenase) from Madin-Darby canine kidney cells on virus infection was prevented by the glycolipids to nearly the same extent as by fetuin. This is the first evidence of the binding- and neutralizing-abilities of native glycoglycerolipids as to influenza viruses.
The influence of liquid metal infiltration on the superconducting characteristics of niobium nitride (1987)

We prepared a fully stabilized, multifilamentary, NbN superconductor using a combination of physical vapor deposition of NbN on graphite fibers followed by liquid metal infiltration using copper or aluminum. The resulting superconductor is in a finely divided multifilamentary form, embedded in a matrix of conductive copper or aluminum. The geometry provides high stability to flux jumps and high quench protection. The effects of liquid metal infiltration and process variables on the electrical properties of NbN have been investigated. Critical current vs field, and stabilizer residual resistivity ratio are discussed as well as the effect of liquid metal infiltration on NbN layer performance.
Chemistry and Biochemistry of Type 2 Diabetes (2004)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry and Biochemistry of Type 2 DiabetesStuart A. Ross, Eric A. Gulve, and Minghan WangView Author Information Department of Cardiovascular and Metabolic Diseases, Mail Zone T2E, Pharmacia Corporation, 800 North Lindbergh Boulevard, St. Louis, Missouri 63167 Cite this: Chem. Rev. 2004, 104, 3, 1255–1282Publication Date (Web):February 19, 2004Publication History Received27 March 2003Published online19 February 2004Published inissue 1 March 2004https://pubs.acs.org/doi/10.1021/cr0204653https://doi.org/10.1021/cr0204653research-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views6042Altmetric-Citations264LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Carbohydrates,Diabetes,Insulin resistance,Peptides and proteins Get e-Alerts
Synthesis of New Monodentate Spiro Phosphoramidite Ligand and Its Application in Rh‐Catalyzed Asymmetric Hydrogenation Reactions. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
&#x201C;Perfect Dispatch&#x201D; - as the measure of PJM real time grid operational performance (2010)

This paper discusses a novel approach for analysis of large scale real time grid operation performance. The PJM Interconnection energy market is one of the largest centralized markets in the world. Recently PJM deployed a newly developed application called “Perfect Dispatch” designed to provide a baseline measure of grid operational performance using retroactive real time market simulation and analysis. In the first nine months of 2009 over $100 million in production cost saving have been attributed to its use. This paper provides an overview of the Perfect Dispatch implementation at PJM and discusses applications and benefits of the “Perfect Dispatch”.
A New Genomics-Driven Taxonomy of Bacteria and Archaea: Are We There Yet? (2016)

Taxonomy is often criticized for being too conservative and too slow and having limited relevance because it has not taken into consideration the latest methods and findings. Yet the cumulative work product of its practitioners underpins contemporary microbiology and serves as a principal means of shaping and referencing knowledge. Using methods drawn from the field of exploratory data analysis, this minireview examines the current state of the field as it transitions from a taxonomy based on 16S rRNA gene sequences to one based on whole-genome sequences and tests the validity of some commonly held beliefs.
WebCT, a tool for the creation of sophisticated web-based learning environments (demonstration) (1997)

No abstract available.
Expression of <i>bcr</i> And <i>bcr-abl</i> Fusion Transcripts in Normal and Leukemic Cells (1987)

The translocation of the c-abl oncogene from chromosome 9 to the bcr gene on chromosome 22 in cases of Philadelphia chromosome-positive chronic myelogenous leukemia (CML) generates an aberrant bcr-abl fusion transcript which may be intimately related to the pathogenesis of CML. Because factors controlling normal bcr expression might also be involved in the expression of this aberrant bcr-abl transcript, we studied the patterns of expression of the normal bcr gene in different cell types. We found that the normal bcr gene was expressed in many different types of human cells. Moreover, the bcr gene was evolutionarily conserved, and homologous bcr genomic sequences and RNA transcripts were readily detected in chick tissue. The highest level of bcr expression in chick tissue was in brain tissue, the lowest level was in liver tissue, and a truncated bcr mRNA was noted in chick testes. Normal bcr transcripts, in addition to the aberrant bcr-abl hybrid transcripts, have been found in all Philadelphia chromosome-positive CML cells studied to date. Within a given CML sample, the relative amounts of normal bcr RNA and aberrant bcr-abl RNA were similar. In addition, the normal bcr and the aberrant bcr-abl hybrid transcripts demonstrated similarly prolonged half-lives compared with that of the normal abl-related transcripts in CML cells. These findings suggest that in CML cells, similar cellular mechanisms control the steady-state levels of both the normal bcr and the bcr-abl fusion RNAs.
Repeatable unipolar/bipolar resistive memory characteristics and switching mechanism using a Cu nanofilament in a GeOx film (2012)

This paper investigates the repeatable unipolar/bipolar resistive switching memory characteristics in a copper/germanium-oxide/tungsten (Cu/GeOx/W) structure. The switching mechanism occurs because of the lower barrier height for hole injection rather than electron injection. Therefore, Cu ions, as a positive charge, migrate before initiating growth at the GeOx/W interface and dissolving at the GeOx/Cu interface. The diameter of the Cu nanofilament increases linearly from 0.13 Å to 25 nm as current compliances increase from 1 nA to 10 mA, as calculated using the other approach. The crystalline Cu nanofilament was also confirmed by high-resolution transmission electron microscopy analysis under SET. Good data retention with high resistance ratios of 102–105 (and >104 at 85 °C) and ∼109 was obtained under the bipolar and unipolar modes, respectively. Therefore, a maximum memory size of 5000 Pbit/in2 can be designed in the future.
Models for tool-path plan optimization in patch-by-patch machining (1998)

In this paper, we address the problem of optimizing the tool path plan for patchby-patch machining of parts having multiple surface patches. The tool path plan defines the sequence in which the patches are to be machined and the entry and exit points for the cutting-tool within each patch. Curent CAD/CAM systems require the user to select the tool path plan. When the number of surface patches increases and alternative machining strategies need to be evaluated, it is often difficult for the user to select the optimal tool path plan that minimizes the total time to machine the part. In this paper, we address three cases of this optimization problem, and present models that can be used to incorporate tool path plan evaluation and optimization capabilities in CAD/CAM systems.
Quantitative Light Fluorescence (QLF) and Polarized White Light (PWL) assessments of dental fluorosis in an epidemiological setting (2012)

The study suggests that the use of a digital imaging system to capture images for either automated software analysis, or remote assessment by raters is suitable for epidemiological work. The use of recorded images enables study archiving, assessment by multiple examiners, remote assessment and objectivity due to the blinding of subject status.
Synthesis and antihypertensive activity of 5-(2-hydroxyphenyl)-1-(3-mercaptopropionyl)-2-pyrrolidinecarboxylic acids. (1985)

The (2S, 5R)-(+)- or (2R, 5S)-(-)-thiol (4a or 4b) was synthesized by catalytic hydrogenation of the corresponding (S)-(-)- or (R)-(+)-pyrrolinecarboxylic acid (8a or 8b) resolved with (R)-(-)-1, 2-diphenylethylamine, followed by acylation with 3-(benzoylthio) propionyl chloride and ammonolysis. The thiols were converted into the corresponding O, S-diacetates (16a and 16b), which were transformed into (2R, 5R)-(+)- and (2S, 5S)-(-)-thiols (18a and 18b) via their O, S-diacetates (17a and 17b) by epimerization and then ammonolysis. The stereochemistry of these thiols was elucidated on the basis of synthesis from tert-butoxycarbonyl-L-glutamic acid γ-benzylester (9) and proton nuclear magnetic resonance (1H-NMR) analysis. The thiols were tested for inhibitory activity against angiotensin-converting enzyme in vitro. (2S, 5R)-5-(2-Hydroxyphenyl)-1-(3-mercaptopropionyl)-2-pyrrolidinecarboxylic acid (4a) showed the most potent activity among them.
Aluminium–ligand cooperation promotes selective dehydrogenation of formic acid to H<sub>2</sub> and CO<sub>2</sub> (2014)

Selective conversion of formic acid to H<sub>2</sub> and CO<sub>2</sub> is catalysed by a molecular aluminum complex. Metal–ligand cooperative interactions stabilize a transition state for an outer-sphere β-hydride abstraction mechanism for catalysis.
Connecting users and items with weighted tags for personalized item recommendations (2010)

Social tags are an important information source in Web 2.0.They can be used to describe users' topic preferences as well as the content of items to make personalized recommendations.However, since tags are arbitrary words given by users, they contain a lot of noise such as tag synonyms, semantic ambiguities and personal tags.Such noise brings difficulties to improve the accuracy of item recommendations.To eliminate the noise of tags, in this paper we propose to use the multiple relationships among users, items and tags to find the semantic meaning of each tag for each user individually.With the proposed approach, the relevant tags of each item and the tag preferences of each user are determined.In addition, the user and item-based collaborative filtering combined with the content filtering approach are explored.The effectiveness of the proposed approaches is demonstrated in the experiments conducted on real world datasets collected from Amazon.com and citeULike website.
Recent advances in the rational design and optimization of antibacterial agents (2016)

Long past the historical “golden era” of antibacterial drug discovery, the modern “resistance era” is being countered by new legislation and advances in the rational design of antibacterial agents.
Bridged polycyclic compounds. LXII. Stereochemistry and mechanisms of electrophilic additions to cyclopropane rings (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridged polycyclic compounds. LXII. Stereochemistry and mechanisms of electrophilic additions to cyclopropane ringsStanley J. Cristol, Wendel Y. Lim, and Alan R. DahlCite this: J. Am. Chem. Soc. 1970, 92, 13, 4013–4017Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://pubs.acs.org/doi/10.1021/ja00716a031https://doi.org/10.1021/ja00716a031research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Pressure/Pressure Transmitters Applied with Semiconductor Sensors (1986)

The optimum design for silicon diaphragm-type pressure sensors and that for a sensing body of the transmitters have been considered. Three types of sensors, which have different section shapes, have been developed for measuring wide-range pressure with high sensitivity and good linearity. The transmitters of the range from 0-100 Pa up to 0-50 MPa with an accuracy of 0.2 percent have been developed. For a differential pressure transmitter a three-metal diaphragm structure has been devised to protect the sensor from an overpressure. The characteristics of the transmitters are high accuracy, high reliability, and long-term stability.
PRIMARY GRAFT FAILURE FOLLOWING HEART TRANSPLANTATION (1999)

394 Objective (s): Primary graft failure (PGF) is a catastrophic event that often leads to death. We sought to determine the incidence of primary graft failure (PGF) following heart transplantation since adopting University of Wisconsin (UW) solution for donor flush preservation. Methods: A retrospective survey, between January 1992 and June 1998, of 545 consecutive orthotopic heart transplants was conducted. During this period we expanded our donor pool by recruiting older and marginal donor organs and initiating an alternate recipient pool. The myocardium was protected with moderate hypothermia, topical endocardial cooling, warm leukocyte-depleted aspartate/glutamate enriched cardioplegia and warm leukocyte-depleted blood reperfusion. Results: The mean age of this group was 47.2 (range, 0.08 to 72 years). The male/female ratio was 9 to 1. Sixty-two (11.4%) recipients were under 18 years of age and 8 (1.5%) were infants under a year old. The remaining 483 patients (88.6%) were adults. Twenty-one patients (21/545) experienced early primary graft failure for an incidence of 3.8%. Graft rescue was attempted with intra-aortic balloon pump (IABP) in 57% (12/21), LVAD in 5% (1/21), RVAD in 5% (1/21) and ECMO in 33% (7/21). Fifty-two percent (11/21) of failing grafts recovered with mechanical support. The overall hospital mortality for this series was 7.7 % (42/545). There have been 82/545 (15%) late deaths over a mean follow-up period of 41.7m (range, 5.9 - 83.6m). Conclusions: Primary allograft failure is a devastating complication occurring in 3.8% of our transplant patients. The high mortality rate is reversible with expeditious mechanical support in over half of these patients.
Sensory-perceptual alterations: delirium in the intensive care unit. (1988)

The delirium that is commonly associated with admission to an intensive care setting (intensive care unit [ICU] psychosis) may be terrifying to the patient, but may go undetected by the nurse. Our current understanding of this delirium is discussed according to incidence, defining characteristics, and etiologic or contributing factors such as predisposing patient factors, pharmacologic agents, and environmental factors. We examine several episodes of delirium that were recounted retrospectively by patients who were discharged from a surgical ICU. These episodes of delirium are examined with reference to sensory-perceptual, perceptual or sensory alterations. We discuss nursing interventions that help to prevent or lessen the impact of delirium before an ICU admission, during the ICU course, and after discharge from the ICU.
Interactive character animation by learning multi-objective control (2018)

We present an approach that learns to act from raw motion data for interactive character animation. Our motion generator takes a continuous stream of control inputs and generates the character's motion in an online manner. The key insight is modeling rich connections between a multitude of control objectives and a large repertoire of actions. The model is trained using Recurrent Neural Network conditioned to deal with spatiotemporal constraints and structural variabilities in human motion. We also present a new data augmentation method that allows the model to be learned even from a small to moderate amount of training data. The learning process is fully automatic if it learns the motion of a single character, and requires minimal user intervention if it deals with props and interaction between multiple characters.
One Step Encapsulation of Small Molecule Drugs in Liposomes via Electrospray-Remote Loading (2015)

Resiquimod is a Toll-like receptor (TLR) 7/8 agonist that has previously been used as a vaccine adjuvant, as a topical treatment of viral lesions and skin cancer, and as an antiviral treatment. We report on the combined application of remote loading and electrospray to produce liposomal resiquimod, with the broader goals of improving drug encapsulation efficiency and scalability of liposome production methods. Drug loading in liposomes increased from less than 1% to greater that 3% by mass when remote loading was used, whether the liposomes were generated by thin-film hydration or electrospray methods. Dynamic light scattering (DLS) determined mean vesicle diameters of 137 ± 11 nm and 103 ± 4 for the thin-film and electrospray methods, respectively. Transmission electron microscopy (TEM) images showed spherical vesicles with sizes consistent with the DLS measurements. In vitro drug release profiles found that most of the drug remained within the liposomes at both pH 5.5 and 7.4. The in vitro bioactivity of the liposomal drug was also demonstrated by the increase in nitrite production when RAW macrophages were exposed to the drug. Our findings indicate that the remotely loaded liposomes formed via the scalable electrospray method have characteristics comparable to those produced via conventional batch methods. The methods discussed here are not limited to the enhanced delivery of resiquimod. Rather, they should be readily adaptable to other compounds compatible with remote loading.