gebhart/patrepeval huggingface dataset:
Control of the Acute Phase Response (1978)

A C T In order to investigate the magnitude and kinetics of the C-reactive protein (CRP) response after differing degrees of tissue injury, we studied changes in serum concentration of this acute phase protein in 19 patients after mild or extensive acute myocardial infarction. An increase in serum CRP concentration was seen in all patients. The rate of increase in concentration was found to be exponential, with a mean hourly rate constant for the entire group of patients of 0.085 (doubling time, 8.2 h). Patients with extensive infarction attained mean serum CRP levels about 4 times as great as did patients with mild infarction. No difference could be shown in the mean rate constant between these groups, the greater CRP response in the former group resulting principally from a more protracted period of rise in serum CRP concentration. A lag period before serum CRP levels began to rise was noted in only 4 of the 13 patients in whom this could be assessed. 7 of 10 patients with presumed unstable angina (coronary insufficiency) showed no rise in CRP concentration, while a small increase as noted in 3 patients. The data suggest that acute tissue injury, such as myocardial infarc- tion, rapidly leads to acceleration in synthesis of CRP, and that the duration of this period of accelera- tion is related to the extent of tissue injury.
Activin B receptor ALK7 is a negative regulator of pancreatic β-cell function (2008)

All major cell types in pancreatic islets express the transforming growth factor (TGF)-beta superfamily receptor ALK7, but the physiological function of this receptor has been unknown. Mutant mice lacking ALK7 showed normal pancreas organogenesis but developed an age-dependent syndrome involving progressive hyperinsulinemia, reduced insulin sensitivity, liver steatosis, impaired glucose tolerance, and islet enlargement. Hyperinsulinemia preceded the development of any other defect, indicating that this may be one primary consequence of the lack of ALK7. In agreement with this, mutant islets showed enhanced insulin secretion under sustained glucose stimulation, indicating that ALK7 negatively regulates glucose-stimulated insulin release in beta-cells. Glucose increased expression of ALK7 and its ligand activin B in islets, but decreased that of activin A, which does not signal through ALK7. The two activins had opposite effects on Ca(2+) signaling in islet cells, with activin A increasing, but activin B decreasing, glucose-stimulated Ca(2+) influx. On its own, activin B had no effect on WT cells, but stimulated Ca(2+) influx in cells lacking ALK7. In accordance with this, mutant mice lacking activin B showed hyperinsulinemia comparable with that of Alk7(-/-) mice, but double mutants showed no additive effects, suggesting that ALK7 and activin B function in a common pathway to regulate insulin secretion. These findings uncover an unexpected antagonism between activins A and B in the control of Ca(2+) signaling in beta-cells. We propose that ALK7 plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca(2+) signaling.
Wirtschaftskreislauf (1992)

Um die Vielzahl von ökonomischen Leistungen und Gegenleistungen zu ordnen und im die volkswirtschaftliche Realität zu vereinfachen, werden gleichartige Wirtschaftssubjekte zu „Sektoren“ zusammengefaßt.
THE EFFECT OF HARPINEA AS PLANT ACTIVATOR IN CONTROL OF BACTERIAL AND FUNGAL DISEASES OF TOMATO (2003)

The objective of this study was to integrate a systemic acquired resistance (SAR) inducing plant activator and available chemical control measures, consequently to determine if comparable efficacy with less chemical applications were possible. Variations in the activity of specific peroxidase enzymes that likely present the enhancement of host resistance were analyzed from the leaves of tomato seedlings after individual and combined applications. The efficacy tests of the compounds against several major diseases of tomato were conducted with replicated pot experiments under controlled conditions in the greenhouse. Possible correlations between higher efficacy of the compound in question and increased specific enzyme activity were evaluated with SPSS 8.0 for Windows.[...]
OPIATE ALKALOIDS AND NITRIC OXIDE PRODUCTION IN THE NEMATODE ASCARIS SUUM (2004)

The tissue distribution, course of secretion, and sex differences of morphine were delineated in Ascaris suum. Nitric oxide (NO) release in various tissues in response to morphine and its metabolite morphine-6-glucuronide (M6G) were also examined. Ascaris suum of both sexes along with their incubation fluid were analyzed for morphine concentrations by high-performance liquid chromatography (HPLC) over a 5-day period. Various tissues were also dissected for HPLC and NO analysis. Morphine was found to be most prevalent in the muscle tissue, and there is significantly more morphine in females than males, probably because of the large amounts present in the female uterus. Morphine (10(-9) M) and M6G (10(-9) M) stimulated the release of NO from muscles. Naloxone (10(-7) M) and N-nitro-L-arginine methyl ester (10(-6) M) blocked (P < 0.005) morphine-stimulated NO release from A. suum muscle tissue. D-Phe-Cys-Tyr-D-Trp-Om-Thr-Pen-Thr-NH2 (CTOP) (10(-7) M) did not block morphine's NO release. However, naloxone could not block M6G-stimulated NO release by muscles, whereas CTOP (10(-7) M) blocked its release. These findings were in seeming contradiction to our earlier inability to isolate a mu opiate receptor messenger RNA by reverse transcriptase-polymerase chain reaction using a human mu primer. This suggests that a novel mu opiate receptor was possibly present and selective toward M6G.
Febrile Core Temperature Is Essential for Optimal Host Defense in Bacterial Peritonitis (2000)

Fever, a nonspecific acute-phase response, has been associated with improved survival and shortened disease duration in infections, but the mechanisms of these beneficial responses are poorly understood. We previously reported that increasing core temperature of bacterial endotoxin (LPS)-challenged mice to the normal febrile range modified expression of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-6, three cytokines critical to mounting an initial defense against microbial pathogens, but survival was not improved in the warmer animals. We speculated that our inability to show a survival benefit of optimized cytokine expression in the warmer animals reflected our use of LPS, a nonreplicating agonist, rather than an infection with viable pathogens. The objective of this study was to determine if increasing murine core temperature altered cytokine expression and improved survival in an experimental bacterial peritonitis model. We showed that housing mice at 35.5 degrees C rather than 23 degrees C increased core temperature from 36.5 to 37.5 degrees C to 39.2 to 39.7 degrees C, suppressed plasma TNF-alpha expression for the initial 48 h, delayed gamma interferon expression, improved survival, and reduced the bacterial load in mice infected with Klebsiella pneumoniae peritonitis. We showed that the reduced bacterial load was not caused by a direct effect on bacterial proliferation and probably reflected enhanced host defense. These data suggest that the increase in core temperature that occurs during bacterial infections is essential for optimal antimicrobial host defense.
3D Photography using Context-aware Layered Depth Inpainting (2020)

We propose a method for converting a single RGB-D input image into a 3D photo - a multi-layer representation for novel view synthesis that contains hallucinated color and depth structures in regions occluded in the original view. We use a Layered Depth Image with explicit pixel connectivity as underlying representation, and present a learning-based inpainting model that synthesizes new local color-and-depth content into the occluded region in a spatial context-aware manner. The resulting 3D photos can be efficiently rendered with motion parallax using standard graphics engines. We validate the effectiveness of our method on a wide range of challenging everyday scenes and show fewer artifacts compared with the state of the arts.
Interleukin-8 Synthesis and the Onset of Labor (1995)

Interleukin-8 is critically involved in the process of parturition in humans. Interleukin-8 concentrations in the myometrium, decidua, and membranes correlated strongly with the observed MMP-8 and MMP-9 concentrations.
Amphetamine selective electrodes based on dibenzo-18-crown-6 and dibenzo-24-crown-8 liquid membranes (1989)

Two novel membrane electrodes highly sensitive and selective for amphetaminium cation are developed and electrochemically evaluated according to IUPAC recommendations. These electrodes Incorporate amphetamine-dibenzo-18-crown-6 (DB18C6) and amphetamine-dibenzo-24-crown-8 (DB24C8) as the active components in 1,2-dichloroethane solvent. Both electrode systems exhibit stable near-Nemstian response over the range 10-2-10-5 M amphetaminium cation with a slope in the range of 55–58 mV/decade of concentration. The working pH range is 3–7, the response time varies from 30 to 50 s and the lower limit of detection is ∼3 ppm. The selectivity toward amphetaminium cation is reasonably high relative to many common inorganic cations and alkaloids as well as some amines structurally related to amphetamine. The DB18C6 membrane is 2–14 times more selective for amphetamine in the presence of foreign compounds than DB24C8 based electrode. Determination of 5 μg mL-1 to 4 mg mL-1 of amphetamine sulfate using the standard addition (spiking) technique shows an average recovery of 98.7% and a mean standard deviation of 1.7%. The method offers several advantages over the standard procedures. © 1989, American Chemical Society. All rights reserved.
Stable Isotope Ratios Using Cavity Ring-Down Spectroscopy:  Determination of <sup>13</sup>C/<sup>12</sup>C for Carbon Dioxide in Human Breath (2002)

We have constructed a cavity ring-down spectrometer employing a near-IR external cavity diode laser capable of measuring 13C/12C isotopic ratios in CO2 in human breath. The system, which has a demonstrated minimum detectable absorption loss of 3.2 x 10(-11) cm(-1) Hz(-1/2), determines the isotopic ratio of 13C16O16O/12C16O16O by measuring the intensities of rotationally resolved absorption features of each species. As in isotope ratio mass spectrometry (IRMS), the isotopic ratio of a sample is compared to that of a standard CO2 sample calibrated to the Pee Dee Belemnite scale and reported as the sample's delta13C value. Measurements of eight replicate CO2 samples standardized by IRMS and consisting of 5% CO2 in N2 at atmospheric pressure demonstrated a precision of 0.22/1000 for the technique. Delta13C values were also obtained for breath samples from individuals testing positive and negative for the presence of Helicobacter pylori, the leading cause of peptic ulcers in humans. This study demonstrates the ability of the instrument to obtain delta13C values in breath samples with sufficient precision to serve as a useful medical diagnostic.
Propylene polymerization using combined syndio‐ and isospecific metallocene catalysts supported on silica/MAO (2005)

Abstract Syndiotactic and isotactic polypropylene were produced using the metallocene compounds Ph 2 C(Flu)(Cp)ZrCl 2 and SiMe 2 (2‐Me,4‐Ph‐Ind) 2 ZrCl 2 in homogeneous system and supported on silica/MAO. These catalysts were evaluated either isolated or as a binary system. In the latter case, the iso‐ and syndiospecific metallocene complexes were immobilized together during the preparation of the supported catalyst. In a further experimental set, the syndio‐ and isospecific isolated heterogeneous catalysts were mixed at the moment of propylene polymerization. The polypropylenes obtained were evaluated using differential scanning calorimetry. The catalytic activities were also investigated. At all the studied polymerization temperatures, the results showed that the binary catalyst produced polypropylenes with lower melting temperatures in comparison with those obtained when the mixture of isolated supported syndio‐ and isospecific catalysts was employed. Moreover, the activation energies for the polymerization of all catalysts systems were calculated, resulting in a lower value for the binary system when compared to that employing the catalyst mixture and to both the isolated supported metallocene catalysts. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 628–637, 2006
Automated Analysis of Optic Nerve Images for Detection and Staging of Papilledema (2011)

These results show that this algorithm can be used to automatically grade papilledema. The algorithm provides objective and quantitative assessment of the stage of papilledema with accuracy that is comparable to grading by a neuro-ophthalmologist. One application is in rapid assessment of digital optic nerve photographs acquired in clinical, intensive care, and emergency response settings by nonophthalmologists to evaluate for the presence and severity of papilledema, due to intracranial hypertension.
Asymmetric Cyclopropanations by Rhodium(II) <i>N</i>-(Arylsulfonyl)prolinate Catalyzed Decomposition of Vinyldiazomethanes in the Presence of Alkenes. Practical Enantioselective Synthesis of the Four Stereoisomers of 2-Phenylcyclopropan-1-amino Acid (1996)

The rhodium N-(arylsulfonyl)prolinate catalyzed decomposition of vinyldiazomethanes in the presence of alkenes leads to a very general method for the synthesis of functionalized cyclopropanes in a highly diastereoselective and enantioselective mode. A detailed study was undertaken to determine the key factors that control the enantioselectivity of this process. The highest levels of enantioselectivity were obtained using cyclic N-(arylsulfonyl)amino acids as ligands for the dirhodium catalyst, and the optimized catalyst was tetrakis[N-[(4-dodecylphenyl)sulfonyl]-(L)-prolinato]dirhodium. The carbenoid structure has a critical effect on the degree of asymmetric induction, and the combination of a small electron-withdrawing group such as a methyl ester and an electron-donating group such as vinyl or phenyl resulted in the highest levels of enantioselectivity. The use of electron neutral alkenes and pentane as solvent also enhanced the enantioselectivity of the process. The synthetic utility of this chemistry was illustrated by its application to the synthesis of all four stereoisomers of 2-phenylcyclopropan-1-amino acid. The occurrence of the highly stereoselective cyclopropanations was rationalized by a model in which the ligands were considered to adopt a D2 symmetric arrangement.
Kerr-effect enhancement and improvement of readout characteristics in MnBi film memory (1974)

Enhancement of the Kerr effect was studied to assess its effectiveness in improving readout characteristics of a magneto-optical memory utilizing MnBi films. SiO was used to enhance the Kerr effect by coating it on magnetic films. The coating results in a change, not only in the Kerr rotation but also in the ellipticity and reflectivity of the films. Changes of these quantities were calculated as a function of the SiO thickness, using optical constants of both MnBi and SiO, i.e., the refractive indices n2 and n3 of SiO and MnBi, respectively, and the off-diagonal element ε′ of the dielectric tensor of MnBi. The optical constants determined in this work were n2=(2.0±0.02)−(0.02±0.02)i, n3=3.1−3.5i, and ε′ = −1.2−0.4i at a wavelength of 6328 Å. The Kerr rotation and the reflectivity were measured for various SiO thicknesses and were compared with the results of theoretical calculations. Experimental and theoretical results agreed well with each other. The readout signal-to-noise ratio, which is a function of the Kerr rotation, ellipticity, and reflectivity, is expected to be improved by a factor of more than 2, when SiO is coated on the MnBi film surface.
Refractory Period and Strophanthin Actions, as Influenced by Four Indole Alkaloids and Two Synthetic Azepinoindoles (1972)

The harmala alkaloids har mane and harmine, the iboga alkaloids ibogamine and tabernanthine, and two synthetic azepinoindoles prolong the functional re fractory period of isolated left guinea pig atria. Actions of k-strophanthin in vitro are modified by these drugs, e.g. concentrations for maximal inotropic action and those forcontracture or standstill are increased. Harmane and the azepinoindoles reduce the inotropic activity of strophanthin. Relationships between chemical structure and pharmacological actions are obvious.
Ac Triport - a New Uninterruptible Ac Power Supply (1978)

A single-phase, 5.6 kVA ac triport has been developed to serve as an uninterruptible power supply (UPS) for use with critical ac loads. The triport's unique feature is its parallel processing of commercial ac line power and of power derived from a central office battery through a continuously operating inverter. The triport is more efficient, more reliable, and less costly than the traditional serial rectifier-inverter UPS.
Studies on a Novel, Potent and Orally Effective Cholecystokinin A Antagonist, FK-480. Synthesis and Structure-Activity Relationships of FK-480 and Related Compounds. (1994)

We prepared various novel tricyclic 1,4-benzodiazepine derivatives as cholecystokinin (CCK) A antagonists, which were evaluated preliminarily for inhibition of 125I-CCK-8 binding to rat pancreatic membranes in vitro and inhibiting effect on CCK-8-induced inhibition of charcoal meal gastric emptying in mice. On the basis of structure-activity relationship (SAR) studies, as well as the stability and availability of the starting materials of those compounds, (S)-N-[1-(2-fluorophenyl)-3,4,6,7-tetrahydro-4-oxo- pyrrolo[3,2,1-jk][1,4]benzodiazepin-3-yl]- 1H-indole-2-carboxamide (9f, FK-480) was selected as a candidate compound for further evaluation. The absolute configuration of the precursor of FK-480, (3S)-amino-1,4-benzodiazepine derivative ((S)-8a, R1 = F) was determined by an X-ray crystallographic study of its ureido derivative with (S)-alpha-methylbenzyl isocyanate. FK-480 is now undergoing clinical studies for the treatment of chronic pancreatitis.
Cationic Rare‐Earth Polyhydrido Complexes: Synthesis, Structure, and Catalytic Activity for the <i>cis</i>‐1,4‐Selective Polymerization of 1,3‐Cyclohexadiene (2006)

Rare activity from rare earths: Cationic rare-earth hydrides show regio- and stereoselectivity for the polymerization of 1,3-cyclohexadiene (CHD) to afford soluble crystalline cis-1,4-linked poly(CHD) that was previously unavailable. These cationic clusters are made by treating the corresponding neutral complexes with a borate activator (see scheme; Cp′: C5Me4SiMe3). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603450_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Assessment of cortical and striatal involvement in 523 Huntington disease brains (2012)

To evaluate the relationship of striatal involvement in Huntington disease (HD) to involvement in other brain regions, CAG repeat size, onset age, and other factors.
Predicting Protein-protein interaction using co-occurring Aligned Pattern Clusters (2015)

Understanding Protein-protein interaction (PPI) is of fundamental importance in deciphering cellular processes. Predicting PPIs is thus critical in making new discoveries in the biological domains. Traditionally, new PPIs are identified through biochemical experiments but such methods are labor-intensive, expensive, time-consuming and technically ineffective due to high false positive rates. Computational docking is an alternative but requires the three-dimensional structures of the target proteins which are not always accessible. Sequence-based prediction is the most readily applicable and cost-effective method. It exploits known PPI Databases to construct classifiers for predicting unknown PPIs based only on sequence data. However, existing methods, adopting features that fix the pattern length and use exact patterns, are biologically unrealistic. Also, those based on SVM and String Kernel are hardly biologically interpretable since they do not compute the features. Recently, we have developed a new method for predicting PPI known as WeMine-P2P based on our WeMine Aligned Pattern Clustering algorithm which discovers and identifies the localized and co-occurring conserved patterns and regions allowing variable length and pattern variations. As our first attempt, under 40 independent experiments, we showed that (1) WeMine-P2P outperforms the well-known algorithm, PIPE2 which also utilizes co-occurring amino acid sequence segments but does not allow variable lengths and pattern variations; (2) Unlike SVM-based methods, WeMine-P2P renders interpretable biological features; (3) WeMine-P2P achieves satisfactory PPI prediction performance, comparable to the SVM-based methods particularly in unseen protein sequences, with a potential reduction of feature dimension of 1280x. WeMine-P2P is extendable to other biosequence interactions such as predicting Protein-DNA interactions.
Analysis and optimization of pilot-symbol-assisted M-QAM for OFDM systems: Research Articles (2005)

Orthogonal frequency division multiplexing (OFDM) is very attractive for next generation high-speed wireless communication because of its various advantages in lessening the severe effects of frequency-selective fading. When using pilot symbol assisted (PSA) M-ary quadrature amplitude modulation (M-QAM) in OFDM systems, if the power of pilot is too low, the channel parameters cannot be accurately estimated, whereas, high pilot power will lead to less power left for data symbols under the condition that the total transmitted power is constrained to be a constant. In this paper, we present how pilot power affects the demodulation performance in Rayleigh fading propagation environments. Consequently, the pilot-to-data power ratio (PDR) is optimized analytically, and degradation of system performance due to inaccurate channel estimation is also evaluated. The theoretical and simulation results show that the optimum PDR is affected by the signal-to-noise ratio (SNR), Doppler frequency and interpolation size etc. When the optimum PDR is adopted for an OFDM system, the total transmission power will be minimal for certain bit error rate (BER) target. Copyright © 2005 John Wiley & Sons, Ltd.
Programmability of Connectivity Control (2021)

Network programmability and edge computing as key features of next generation communications enable innovative services. While the programmability is focused on the core network of the fifth-generation system, the edge computing moves the network intelligence to the radio access network. This paper presents a study on the programmability of connectivity control as a function of radio access network using Multi-access Edge Computing. The capability of using more than one radio access technology simultaneously enhances reliability and increases the throughput, especially in dense networks. Opening the radio access network interfaces for programmability of multi-connectivity enables analytics applications to control the device connections to multiple radio links simultaneously based on information of radio conditions, user location or specific policies. The research novelty is in opening the radio access network interfaces for edge applications to access connectivity control.