gebhart/patrepeval huggingface dataset:
Dramatically Enhanced Visible Light Response of Monolayer ZrS2 via Non-covalent Modification by Double-Ring Tubular B20 Cluster (2016)

The ability to strongly absorb light is central to solar energy conversion. We demonstrate here that the hybrid of monolayer ZrS<sub>2</sub> and double-ring tubular B<sub>20</sub> cluster exhibits dramatically enhanced light absorption in the entire visible spectrum. The unique near-gap electronic structure and large built-in potential at the interface will lead to the robust separation of photoexcited charge carriers in the hybrid. Interestingly, some Zr and S atoms, which are catalytically inert in isolated monolayer ZrS<sub>2</sub>, turn into catalytic active sites. The dramatically enhanced absorption in the entire visible light makes the ZrS<sub>2</sub>/B<sub>20</sub> hybrid having great applications in photocatalysis or photodetection.
BOC(x,y) Signal Acquisition Techniques and Performances (2003)

The introduction of the BOC modulation (Binary Offset Carrier) in the future GNSS signals will open the field to enhanced navigation performances and spectrum compatibility : GALILEO signals plan proposes to use BOC modulation for Open Service (OS), Safety of Life Service (SOL) and even Public Regulated Service (PRS). On the other hand, GPS M-Code also plans to use BOC modulation. BOC modulation is then a key issue for However, using such a modulation means to cope with ambiguities created in the auto-correlation function. In particular, these ambiguities apparently make the signal acquisition process more complex: the point is first to find energy avoiding local zero in the auto-correlation function (energy search phase), then to transit to a tracking status on the main peak (transition phase) before being able to benefit from the full BOC performances effect. This paper presents one technique to achieve BOC acquisition: it describes the acquisition process principles and its performances. This technique has been implemented in a simulator based on a Simulink and Matlab software and evaluated under different conditions (according to (x,y) values, dynamic conditions, etc.). Of course, the Time To First Fix (TTFF), the robustness and the receiver complexity impact are evaluated. As a result, the feasibility of a quick, efficient, and simple acquisition process is demonstrated.
Modeling of Lithography Related Yield Losses for CAD of VLSI Circuits (1985)

In this paper, a modeling technique, describing IC manufacturing yield losses in terms of parameters characterizing lithography related point defects and line registration errors, is presented. Optimization of geometrical design rules, evaluation of VLSI IC artwork, and maximization of the wafer yield are discussed as examples illustrating applications and advantages of the proposed modeling technique.
BODIPY triads triplet photosensitizers enhanced with intramolecular resonance energy transfer (RET): broadband visible light absorption and application in photooxidation (2013)

Resonance energy transfer (RET) was used to enhance the light absorption in triad triplet photosensitizers to access strong and broadband absorption in visible region (from 450–750 nm). This strategy was demonstrated by preparation of (BODIPY)2-diiodo-aza-BODIPY triad (B-2) and (carbazole-styryl BODIPY)2-diiodo-aza-BODIPY triad (B-3), in which the energy donor (BODIPY or styryl-BODIPY) and the energy acceptor (aza-BODIPY, also as the spin converter) parts were connected by click chemistry. Both the energy donors and the energy acceptors show strong absorption in the visible spectral region, but at different wavelengths, therefore the triads show broadband absorption in visible spectra region, e.g. the two major absorption bands of B-3 are located at 593 nm and 683 nm, with ε up to 220 000 M−1 cm−1 and 81 000 M−1 cm−1, respectively. For comparison, a reference compound with only diiodo-aza-BODIPY as the light-harvesting unit was prepared (B-1), which shows only one major absorption band in visible spectral region. Fluorescence studies indicated intramolecular energy transfer for these BODIPY hybrids, a conclusion which is supported by the femtosecond time-resolved transient absorption spectroscopy. Nanosecond transient absorption spectra show that triplet excited states of the dyad and the triad are localized on the iodo-aza-BODIPY part. The compounds were used as triplet photosensitizers for singlet oxygen (1O2) mediated photooxidation of 1,5-dihydroxylnaphthalene and the photosensitizing ability of the new triplet photosensitizers are more efficient than the mono-chromophore based triplet photosensitizers. The molecular design rationale of these RET-enhanced multi-chromophore triplet photosensitizer is useful for development of efficient triplet photosensitizers and for their applications in photocatalysis, photodynamic therapy, photovoltaics and upconversion.
Crystallographic Trapping of the Glutamyl-CoA Thioester Intermediate of Family I CoA Transferases (2005)

Coenzyme A transferases are involved in a broad range of biochemical processes in both prokaryotes and eukaryotes, and exhibit a diverse range of substrate specificities. The YdiF protein from Escherichia coli O157:H7 is an acyl-CoA transferase of unknown physiological function, and belongs to a large sequence family of CoA transferases, present in bacteria to humans, which utilize oxoacids as acceptors. In vitro measurements showed that YdiF displays enzymatic activity with short-chain acyl-CoAs. The crystal structures of YdiF and its complex with CoA, the first co-crystal structure for any Family I CoA transferase, have been determined and refined at 1.9 and 2.0 A resolution, respectively. YdiF is organized into tetramers, with each monomer having an open alpha/beta structure characteristic of Family I CoA transferases. Co-crystallization of YdiF with a variety of CoA thioesters in the absence of acceptor carboxylic acid resulted in trapping a covalent gamma-glutamyl-CoA thioester intermediate. The CoA binds within a well defined pocket at the N- and C-terminal domain interface, but makes contact only with the C-terminal domain. The structure of the YdiF complex provides a basis for understanding the different catalytic steps in the reaction of Family I CoA transferases.
Test Coverage Analysis of UML State Machines (2010)

Software testing is a very important activity of the software development process. To expedite the testing process and improve the quality of the tests, models are increasingly used as a basis to derive test cases automatically - a technique known as model-based testing (MBT). Given a system model and a test suite derived automatically from the model or created by other process, the coverage of the model achieved by the test suite is important to assess the quality and completeness of the test suite early in the software development process. This paper presents a novel tool that shows visually the coverage achieved by a test suite on a UML state machine model. The tool receives as input a UML state machine model represented in XMI and a test suite represented in a XML format, and produces a colored UML state machine model that shows the coverage result. Model test coverage is determined by simulating the execution of the test suite over the model. An example is presented in order to show the features of the tool.
Analysis of a prototype intelligent network interface (2003)

Abstract With a focus on commodity PC systems, Beowulf clusters traditionally lack the cutting edge network architectures, memory subsystems, and processor technologies found in their more expensive supercomputer counterparts. Many users find that what Beowulf clusters lack in technology, they more than make up for with their significant cost advantage. In this paper, an architectural extension that adds reconfigurable computing to the network interface of Beowulf clusters is proposed. The proposed extension, called an intelligent network interface card (or INIC), enhances both the network and processor capabilities of the cluster, which has a significant impact on the performance of a crucial class of applications. Furthermore, for some applications, the proposed extension partially compensates for weaknesses in the PC memory subsystem. A prototype of the proposed architecture was constructed and analyzed. In addition, two applications, the 2D Fast Fourier Transform (2D‐FFT) and integer sorting, which benefit from the resulting architecture, are discussed and analyzed on the proposed architecture. Specifically, results indicate that the 2D‐FFT is performed 15–50% faster when using the prototype INIC rather than the comparable Gigabit Ethernet. Early simulation results also indicate that integer sorting will receive a 21–32% performance boost from the prototype. The significant improvements seen with a relatively limited prototype lead to the conclusion that cluster network interfaces enhanced with reconfigurable computing could significantly improve the Beowulf architecture. Copyright © 2003 John Wiley & Sons, Ltd.
HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression (2014)

Mutations in HFE are the most common cause of hereditary hemochromatosis (HH). HFE mutations result in reduced expression of hepcidin, a hepatic hormone, which negatively regulates iron absorption from the duodenum and iron release from macrophages. However, the mechanism by which HFE regulates hepcidin expression in hepatocytes is not well understood. It is known that the bone morphogenetic protein (BMP) pathway plays a central role in controlling hepcidin expression in the liver. Here we show that HFE overexpression increased Smad1/5/8 phosphorylation and hepcidin expression, whereas inhibition of BMP signaling abolished HFE-induced hepcidin expression in Hep3B cells. HFE was found to associate with ALK3, inhibiting ALK3 ubiquitination and proteasomal degradation and increasing ALK3 protein expression and accumulation on the cell surface. The 2 HFE mutants associated with HH, HFE C282Y and HFE H63D, regulated ALK3 protein ubiquitination and trafficking differently, but both failed to increase ALK3 cell-surface expression. Deletion of Hfe in mice resulted in a decrease in hepatic ALK3 protein expression. Our results provide evidence that HFE induces hepcidin expression via the BMP pathway: HFE interacts with ALK3 to stabilize ALK3 protein and increase ALK3 expression at the cell surface.
Non-invasive antromycosis (Diagnosis and treatment) (1982)

Increasing numbers of cases of chronic maxillary sinusitis are encountered which resist frequent sinus irrigation and treatment of predisposing factors. The antral washouts are of unusual consistencies and colours. The antral washouts of six cases were investigated by culture and microscopic examination and proved to contain fungal colonies. Antroscopy was a valuable asset in diagnosis. One patient had a Caldwell-Luc operation and daily irrigation through an indwelling polythene tube followed by daily instillation of clotrimazole (Canesten). The five patients who refused operation were treated by repeated bi-weekly antral washouts followed by instillation of clotrimazole. Weekly samples of antral secretions were examined by culture and microscopic examination until they were free for four consecutive weeks. We believe that frequent antral irrigation and local instillation of a broad-spectrum antimycotic drug--preferably after debridement--is the treatment of choice for antromycosis.
In Vivo Biologic Activities of Recombinant Human Granulocyte‐Macrophage Colony‐Stimulating Factor (1989)

We evaluated the biologic effects of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) in 25 patients with malignancy and/or bone marrow failure of diverse etiologies. The continuous infusion of GM-CSF (15 to 500 micrograms/m2/day) elicited marked leukocytosis (2- to 70-fold increase), consisting primarily of neutrophils, eosinophils, and monocytes. Six patients with cytopenias experienced a multilineage response characterized by significant increases in platelet counts and improvement in erythropoiesis. Response in blood counts was accompanied by significant increases in bone marrow cellularity, myeloid:erythroid cell ratios, and frequency of cycling progenitors, indicating an effect at the stem cell level. By premature chromosome condensation analysis, neutrophils from patients with myeloid diseases were found to be derived from normal as well as abnormal clones. Side effects were generally mild and commonly included constitutional symptoms and bone pain. These results indicate that GM-CSF is a significant stimulus for hematopoiesis in vivo and might play an important role in several clinical arenas.
Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells (2013)

The HDACi entinostat, selective for inhibition of class I HDACs, induced virus expression in latently infected primary CD4⁺ T cells making this compound an attractive novel option for future clinical trials.
Thermodynamic properties and atomic structure of Ca-based liquid alloys (2013)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2013.
Chemoenzymatic Synthesis of the 9-Deoxy- 9-fluoro-[3-<sup>13</sup>C]-NeuAc-α-(2→6)-[U-<sup>13</sup>C]-Gal-β- Sequence on an Intact Glycoprotein (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTChemoenzymatic Synthesis of the 9-Deoxy- 9-fluoro-[3-13C]-NeuAc-α-(2→6)-[U-13C]-Gal-β- Sequence on an Intact GlycoproteinTatsuo Miyazaki, Tohru Sakakibara, Hajime Sato, and Yasuhiro KajiharaView Author Information Graduate School of Integrated Science, and Faculty of Science Yokohama City University, 22-2, Seto, Kanazawa-ku Yokohama 236-0027, Japan Bruker Japan Co., Ltd. 21-5, Ninomiya, 3-chome, Tsukuba Ibaraki 305-0051, Japan Cite this: J. Am. Chem. Soc. 1999, 121, 6, 1411–1412Publication Date (Web):January 29, 1999Publication History Received17 August 1998Published online29 January 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/ja982950ehttps://doi.org/10.1021/ja982950erapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views276Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Carbohydrates,Conformation,Degradation,Nuclear magnetic resonance spectroscopy,Peptides and proteins Get e-Alerts
Bias-Variance Analysis of Support Vector Machines for the Development of SVM-Based Ensemble Methods (2004)

Bias-variance analysis provides a tool to study learning algorithms and can be used to properly design ensemble methods well tuned to the properties of a specific base learner. Indeed the effectiveness of ensemble methods critically depends on accuracy, diversity and learning characteristics of base learners. We present an extended experimental analysis of bias-variance decomposition of the error in Support Vector Machines (SVMs), considering Gaussian, polynomial and dot product kernels. A characterization of the error decomposition is provided, by means of the analysis of the relationships between bias, variance, kernel type and its parameters, offering insights into the way SVMs learn. The results show that the expected trade-off between bias and variance is sometimes observed, but more complex relationships can be detected, especially in Gaussian and polynomial kernels. We show that the bias-variance decomposition offers a rationale to develop ensemble methods using SVMs as base learners, and we outline two directions for developing SVM ensembles, exploiting the SVM bias characteristics and the bias-variance dependence on the kernel param
Distributional clustering of English words (1993)

We describe and evaluate experimentally a method for clustering words according to their distribution in particular syntactic contexts. Words are represented by the relative frequency distributions of contexts in which they appear, and relative entropy between those distributions is used as the similarity measure for clustering. Clusters are represented by average context distributions derived from the given words according to their probabilities of cluster membership. In many cases, the clusters can be thought of as encoding coarse sense distinctions. Deterministic annealing is used to find lowest distortion sets of clusters: as the annealing parameter increases, existing clusters become unstable and subdivide, yielding a hierarchical "soft" clustering of the data. Clusters are used as the basis for class models of word coocurrence, and the models evaluated with respect to held-out test data.
Global inhibition of translation and activation of the stress induced protein kinase cascade through TAK1-D by small double stranded RNA molecules of specific sequence (2008)

4122 Short double stranded RNAs (dsRNA) are potent biological entities triggering a number of cellular effects. Most prominent among these is the post-transcriptional silencing of target genes by small interfering RNAs (siRNAs). In addition dsRNAs activate signal transduction processes through molecules like PKR or the Toll-like receptor important in viral defense and in explaining off target effects of siRNAs. We have identified a novel dsRNA triggered pathway leading to cell death in several non small cell lung cancer (NSCLC) cell lines.  Using the human NSCLC cell line NCI-H460 as a model system we found that transfection of these cells with a 19 base pair long double stranded RNA of specific sequence leads to the downregulation of global mRNA translation. Protein synthesis was reduced to about 65% of its initial value 4 hours after transfection with 20 nM of the dsRNA. Mutational studies demonstrated that 4 consecutive U or A ribonucleotides in the 5’ region of the sense strand as well as the sequence AUGA close to the 3’end of the sense strand are the sequence motifs required to trigger this effect. dsRNA mediated inhibition of translation leads to the autophosphorylation and activation of the splicing variant D of the mitogen activated protein kinase kinase kinase TAK1. Using sucrose density gradient centrifigation we found that TAK1-D co-localizes with the 80S ribosome and therefore seems to be associated with the ribosome. The activation of TAK1-D leads to the phosphorylation of its downstream targets MKK4 and MKK3/6, triggering the activation of p38 MAPK and SAPK/JNK. In H460 cells the TAK1-D triggered activation of the stress induced protein kinase cascades leads to cell cycle arrest and apoptosis.  Interestingly this phenomenon could also be observed in other NSCLC cell lines like HCC2279 but not in normal bronchial epithelial cells.  The sequence specificity of dsRNA mediated cell death in NSCLC cells as well the lack of an effect on normal bronchial epithelial cells suggests that this effect might offer a new therapeutic option for these types of cancer.
High impedance fault detection in EHV series compensated lines using the wavelet transform (2009)

Coupling capacitive voltage transformers behave as low pass filters which reject the high frequencies associated with voltage signals, so the effect of HIF on voltage signals is neglected. In addition, using series capacitors (SCs) equipped with metal oxide varistors (MOVs) increases the protection relaying problems and complicates the trip decision. This paper presents a high impedance fault detection algorithm for maximum trip time required of 3/4 cycle. The proposed scheme implemented on two different models of HIF in extra high voltage double-ended transmission lines with series capacitors at the middle of the line. The scheme recognizes the distortion of the voltage waveforms caused by the arcs usually associated with HIFs. The discrete wavelet transform (DWT) based analysis, yields three phase voltages in high frequency range which are fed to Clarke's transformation to produce ground and aerial modes voltage components for pattern recognition. The classifier is based on an algorithm that uses recursive method to sum the absolute values of high frequency signals generated over one cycle and shifts one sample. Characteristics of the proposed scheme are fully analyzed by extensive ATP/EMTP simulation studies that clearly reveal that the proposed method can accurately detect HIFs in EHV transmission lines and does not affected by different fault conditions such as fault distance and fault inception angle.
Life outside academia: on becoming an expert teacher-researcher (2015)

Abstract The author, a school principal with significant classroom responsibilities recounts his journey towards authenticity as an independent teacher-researcher. His career as a researcher began in the scientific-knowledge tradition and then moved into the practical-knowledge tradition. He describes how Donald Schön, the father of reflective practice, has transformed his professional life, leading him to develop a deeply thoughtful practice, one that makes use of the literature to augment, challenge, and legitimise the work he does in his school. The author delves into the messy world of the professional experiment, and the idea that professionals can, and do, act and think differently to third-person researchers. Finally, the author shares his story about how the members of a virtual community of scholars have facilitated his move from the periphery of the researching community into an authentic and valued practitioner-colleague with a personal theory of practice
Synergism between the analgesic actions of morphine and pentazocine (1988)

In a double-blind, placebo-controlled study the analgesic efficacy of the combination of morphine, a mu-opiate receptor agonist and pentazocine, a kappa-opiate receptor partial-agonist was evaluated. Groups of 20 patients received either vehicle, morphine (2, 4, 8 or 16 mg), pentazocine (15, 30 or 60 mg) or a combination of morphine and pentazocine (2 mg or 4 mg and 15 mg or 30 mg, respectively). The combination of morphine and pentazocine produced a level of analgesia significantly greater than can be accounted for by simple addition of the analgesic effects of each opiate analgesic alone. We propose that the observed synergism between morphine and pentazocine is due to interaction between mu- and kappa-opioidergic components of endogenous opioid-mediated analgesia systems.
Liver Imaging Reporting and Data System with MR Imaging: Evaluation in Nodules 20 mm or Smaller Detected in Cirrhosis at Screening US (2015)

In patients with cirrhosis with US-detected nodules 20 mm or smaller, both LI-RADS category 4 and category 5 have high specificity for HCC. In addition, a relevant proportion of lesions categorized as LI-RADS category 2 or 3 or as other malignancies were HCCs. Thus, active diagnostic work-up, including biopsy to allow prompt treatment, is recommended in such patients. Online supplemental material is available for this article.