gebhart/patrepeval huggingface dataset:
Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-C activities via coupling to G alpha q/11. (1995)

Oxytocin stimulates phosphoinositide turnover in myometrium. To elucidate whether the coupling mechanism involves the interaction of oxytocin receptor with GTP-binding proteins, we examined oxytocin stimulation of guanosine triphosphatase (GTPase) activity and phospholipase-C activity in rat and human myometrial membranes. Oxytocin consistently stimulated both GTPase and phospholipase-C activities, and both stimulations were attenuated by an antibody directed against the carboxyl-terminals of the GTP-binding proteins, G alpha q and G alpha 11. Neutralization of the antibody by preincubation with antigenic peptide reversed this inhibition. [Thr4,Gly7]oxytocin, a specific oxytocin receptor agonist, stimulated both GTPase and phospholipase-C activities, and the stimulations were also inhibited by anti-G alpha q/11 IgG. Immunoreactive GTP-binding proteins, G alpha q and G alpha 11, and phospholipase-C beta 3 isoforms were present in myometrial membranes. These results indicate that stimulation of phospholipase-C activity by oxytocin in myometrium is mediated via G alpha q, G alpha 11, or a closely related GTP-binding protein, probably coupling to phospholipase-C beta.
Bone Formation Rate in Older Normal Women: Concurrent Assessment with Bone Histomorphometry, Calcium Kinetics, and Biochemical Markers* (1988)

In 12 younger (age, 30-41 yr) and 11 older (age, 55-73 yr) normal women we assessed bone formation rate using multiple methods. Bone formation (mean +/- SE) was higher in the older women than in the younger women, based on measurements of serum bone Gla-protein (1.67 +/- 0.07 vs. 1.14 +/- 0.10 nmol/L; P less than 0.01), serum bone-specific alkaline phosphatase activity (388 +/- 42 vs. 223 +/- 22 nanokatal/L, P less than 0.01), and bone formation rate by histomorphometry of iliac biopsy (31.1 +/- 4.9% vs. 15.1 +/- 2.7%/yr; P less than 0.01), but was similar in the two groups when accretion rates were assessed by calcium kinetics (5.9 +/- 1.0 vs. 7.5 +/- 1.2; P = NS). This latter discrepancy may have been caused by several age-related factors, especially reduced mineralization of completed osteons, and by not correcting for the decrease in total skeletal calcium in the older group. Our data call into question the traditional belief that bone turnover decreases in older women.
Assessment of potential greenhouse gas mitigation from changes to crop root mass and architecture (2016)

Reducing (and eventually reversing) the increase in greenhouse gases (GHGs) in the atmosphere due to human activities, and thus reducing the extent and severity of anthropogenic climate change, is one of the great challenges facing humanity. While most of the man-caused increase in GHGs has been due to fossil fuel use, land use (including agriculture) currently accounts for about 25% of total GHG emissions and thus there is a need to include emission reductions from the land use sector as part of an effective climate change mitigation strategy. In addition, analyses included in the recent IPCC 5th Climate Change Assessment report suggests that it may not be possible to achieve large enough emissions reductions in the energy, transport and industrial sectors alone to stabilize GHG concentrations at a level commensurate with a less than 2°C global average temperature increase, without the help of a substantial CO2 sink (i.e., atmospheric CO2 removal) from the land use sector. One of the potential carbon sinks that could contribute to this goal is increasing C storage in soil organic matter on managed lands. This report details a preliminary scoping analysis, to assess the potential agricultural area in the US – where appropriate soil, climate and land use conditions exist – to determine the land area on which ‘improved root phenotype’ crops could be deployed and to evaluate the potential long-term soil C storage, given a set of ‘bounding scenarios’ of increased crop root input and/or rooting depth for major crop species (e.g., row crops (corn, sorghum, soybeans), small grains (wheat, barley, oats), and hay and pasture perennial forages). The enhanced root phenotype scenarios assumed 25, 50 and 100% increase in total root C inputs, in combination with five levels of modifying crop root distributions (i.e., no change and four scenarios with increasing downward shift in root distributions). We also analyzed impacts of greater root production on the soil-crop nitrogen balance, from the standpoint of increased need for additional N inputs and consequences for increased N2O flux, as well as potential impacts if more and deeper roots contributed to reduced N leaching. In the enhanced root phenotype scenarios, the implicit assumption was that increases in overall plant production could be achieved (e.g., through increased CO2 assimilation, greater growth efficiency) without reducing the harvested yield – that is, we did not include potential leakage and land substitution effects from potential decreased crop yield in the analysis.
Electromanipulation of plant protoplasts (1986)

The current status of electromanipulation, that is, electrofusion and electroporation, of plant protoplasts is reviewed. Parameters for electromanipulation as well as their practical implications are discussed. Some comparisons with the use of polyethylene glycol are made and the advantages of electromanipulation are considered.
Risk assessment of power system with high penetration of wind power considering negative peak shaving and extreme weather conditions (2014)

The variation of wind power affects the operation of coal-wind intensive system. With the negative peak character, the variation of wind power daily output is in contrast to that of the load in power system. Even worse case is the common-mode tripping of wind turbines closing to cut-off wind speed while a wind farm experience extreme wind speeds caused by a severe weather situation. Based on actual operation data of Gansu Grid, China, in 2013, the probability characters of negative peak shaving and ramp rate are obtained. Then some risk indices are defined for risk assessment and the UC model is applied to probe the increment of reserve demand. A simulation based on Gansu Grid is given at last. The results show that the reserve demand increases with the wind power integration and the operation risk has a typical distribution of exponential function contains two types of risk events: HILF (High Impact and Low Frequency) and LIHF (Low Impact and High Frequency).
Human Resource Development by Fuzzy Neural Networks (2008)

The human resource function is more important than ever before, it must become strategic rather than merely administrative than it used to be. Human resource development is based on the beliefs that organizations are human-made entities that rely on human expertise in order to establish and achieve their goals. By analyze the effect factors of employee's value, this paper proposes a fuzzy neural network approach for human resource development.
Advanced Coarsening Schemes for Graph Partitioning (2015)

The graph partitioning problem is widely used and studied in many practical and theoretical applications. Today, multilevel strategies represent one of the most effective and efficient generic frameworks for solving this problem on large-scale graphs. Most of the attention in designing multilevel partitioning frameworks has been on the refinement phase. In this work, we focus on the coarsening phase, which is responsible for creating structures similar to the original but smaller graphs. We compare different matching- and AMG-based coarsening schemes, experiment with the algebraic distance between nodes, and demonstrate computational results on several classes of graphs that emphasize the running time and quality advantages of different coarsening schemes.
Genetic variants in the α2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses (2008)

Variation in genes that regulate sympathetic activity affects hemodynamic stress responses and contributes to their ethnic differences. This study elucidates how genetic factors may in part explain ethnic differences in cardiovascular regulation.
Performance analysis of Closed and Open loop MIMO in LTE (2009)

This paper provides a detailed performance comparison between closed loop (CL) and open loop (OL) MIMO schemes for the upcoming OFDM based mobile broadband radio access technology 3GPP UTRA LTE. Based on system level simulation results, key performance indicators like cell throughput, user throughput and MIMO utilization have been evaluated for different system load conditions assuming 2×2 MIMO in a regular hexagonal cell deployment and in a real network scenario. A realistic dynamic MIMO switch between diversity and spatial multiplexing has been assumed, which is based on configurable CQI as well as rank filtering and decision thresholds. 3GPP compliant measurement granularity as well as appropriate measurement errors have been applied to both CQI and closed loop PMI reports. Besides dynamic MIMO switching, both MIMO 2×2 diversity and MIMO 2×2 spatial multiplexing scenarios have been investigated for the downlink direction highlighting the differences of the various MIMO transmission modes and their impacts on spectral efficiency and radio performance. It has been shown that ideal closed loop MIMO provides a 2 dB theoretical performance gain over open loop MIMO. Assuming practical limitations such as available granularity, delay and realistic PMI measurement errors, however, this gain significantly decreases below roughly 1 dB. Nevertheless MIMO proves to be an appropriate method to boost user throughput especially at low to medium system load up to a factor of 2. Moreover the dynamic MIMO switch proves to be very robust against variations of parameter settings.
Detection and classification of thyroid follicular lesions based on nuclear structure from histopathology images (2010)

Follicular lesions of the thyroid are traditionally difficult and tedious challenges in diagnostic surgical pathology in part due to lack of obvious discriminatory cytological and microarchitectural features. We describe a computerized method to detect and classify follicular adenoma of the thyroid, follicular carcinoma of the thyroid, and normal thyroid based on the nuclear chromatin distribution from digital images of tissue obtained by routine histological methods. Our method is based on determining whether a set of nuclei, obtained from histological images using automated image segmentation, is most similar to sets of nuclei obtained from normal or diseased tissues. This comparison is performed utilizing numerical features, a support vector machine, and a simple voting strategy. We also describe novel methods to identify unique and defining chromatin patterns pertaining to each class. Unlike previous attempts in detecting and classifying these thyroid lesions using computational imaging, our results show that our method can automatically classify the data pertaining to 10 different human cases with 100% accuracy after blind cross validation using at most 43 nuclei randomly selected from each patient. We conclude that nuclear structure alone contains enough information to automatically classify the normal thyroid, follicular carcinoma, and follicular adenoma, as long as groups of nuclei (instead of individual ones) are used. We also conclude that the distribution of nuclear size and chromatin concentration (how tightly packed it is) seem to be discriminating features between nuclei of follicular adenoma, follicular carcinoma, and normal thyroid.
The family of nested factorizations (2007)

This paper describes a family of Nested Factorization (NF) algorithms, which are used as preconditioners in the iterative solution of sparse linear systems arising in discretization of elliptic or parabolic PDE in 2D and 3D. Nested factorization differs from the widely used incomplete LU/Cholesky factorizations in that the preconditioning matrix in NF is not formed strictly from upper and lower factors. Instead, NF exploits the nested triangular structure of the original matrix by defining the preconditioner matrix as a sequence of level matrices with the diagonal matrix on the lowest level. We present the variants of NF and Generalized NF (GNF) for systems arising in regular 7-point stencil and block 7-point stencil discretizations of PDE on structured grids, respectively. We also introduce a variant of Nested Factorization named UNF, applied to matrices arising in discretization of PDE on unstructured grid. This variant is based on a special reordering technique which recovers a multi-level structure for a general sparse matrix. Numerical results presented in the paper show that nested factorization algorithms give faster convergence and require less memory than ILU-type methods for sets of test matrices.
The RF spectra of first and subsequent lightning return strokes in the 1‐ to 200‐km range (1980)

We present the first experimental characterization of the frequency spectra of first and subsequent stroke electric fields over a distance range from about 1 km, where the fields are primarily electrostatic, to 200 km, where they are primarily radiation. Spectra are presented to about 700 kHz for lightning within 12 km and to about 300 kHz for lightning at 50 and 200 km. We show that the return stroke ground wave spectrum beyond 50 km has a peak near 4 kHz but that within 10 km the spectrum shows a steady increase with decreasing frequency to 1 kHz. Subsequent strokes beyond 50 km contain more energy above 100 kHz relative to the peak spectral value than do first strokes. Frequency spectra at all ranges fall off roughly as 1/ƒ for frequencies between 5 and 100 kHz, whereas the falloff above 100 kHz is faster as the distance to the stroke increases. From this high‐frequency attenuation we determine an RF conductivity for central Florida of between 0.002 and 0.005 Ω −1 /m.
Epoxy resins for molding application (1979)

Epoxy resins offer many advantages over other resin types for the encapsulation of active semi conductor devices. Of particular importance in this area are the epoxy cresol novolacs.
Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium (1990)

In a variety of lung diseases the respiratory epithelial surface must contend with an increased burden of neutrophil elastase (NE). One candidate for augmenting epithelial anti-NE protection is the secretory leukoprotease inhibitor (SLPI). In vitro evaluation demonstrated that 96 +/- 1% of the recombinant SLPI (rSLPI) molecules were capable of inhibiting NE, with an association rate constant of 7.1 +/- 0.1 X 10(6) M-1.s-1. Evaluation of rSLPI after in vitro and in vivo aerosolization showed that aerosolization did not alter rSLPI. Aerosolization of a single dose of 50 mg rSLPI to sheep resulted in a fourfold increase of the anti-NE capacity in epithelial lining fluid (ELF) at 3 h, with a half-life in ELF of 12 h. After aerosolization some rSLPI appeared in lung lymph. Simultaneous aerosolization of rSLPI and recombinant alpha 1-antitrypsin (rAAT) demonstrated a molar ratio of the concentration in lymph to the concentration in ELF 3 h after the aerosol eightfold higher for rAAT than for rSLPI. Overall, these observations demonstrate that it is feasible to use aerosolized rSLPI to directly augment the anti-NE capacity of the lung, particularly on the pulmonary epithelial surface.
Improved Solid-State Photomechanical Materials by Fluorine Substitution of 9-Anthracene Carboxylic Acid (2014)

Four fluorinated derivatives of 9-anthracene carboxylic acid (9AC), a molecule that shows a reversible photomechanical response in its crystal form, have been synthesized and characterized. The spectroscopic properties and crystal structures of 4-fluoro-9-anthracene carboxylic acid (4F-9AC), 2-fluoro-9-anthracene carboxylic acid (2F-9AC), 10-fluoro-9-anthracene carboxylic acid (10F-9AC), and 2,6-difluoro-9-anthracene carboxylic acid (2,6DF-9AC) are all very similar to those of 9AC. However, their photomechanical properties vary widely. 405 nm light was used to induce [4 + 4] photodimerization and a mechanical response in crystalline microneedles and ribbons. Both the photodimer dissociation rate and the mechanical recovery varied by more than an order of magnitude, with 4F-9AC exhibiting the most rapid recovery time, on the order of 30 s. Nanoindentation measurements show that this crystal has a slightly reduced elastic modulus and a significantly reduced hardness, making it less brittle than the 9AC crystal. Large 4F-9AC crystals remain intact after irradiation, without fragmenting, while microneedles can undergo more than 100 mechanical bending cycles. Given the similarity of the crystal packing in all five molecules, the improved photomechanical properties must arise from subtle changes in intermolecular interactions or possibly differences in disorder. These results demonstrate that it is possible to significantly improve the properties of photomechanical materials through small modifications of the molecular structure.
Nuclear Run-On Assay Using Biotin Labeling, Magnetic Bead Capture and Analysis by Fluorescence-Based RT-PCR (2000)

In this report, we present a fluorescence-based approach to the assessment of cellular gene expression and transcription rates. Nuclear run-on was performed by supplying biotin-16-UTP to nuclei, and labeled transcripts were bound to streptavidin-coated magnetic beads. Total cDNA was then synthesized by means of random hexamer primed reverse transcription of captured molecules. To monitor transcript abundance in cDNA, both from nuclear run-on and total RNA, we propose a semiquantitative PCR approach based on the use of fluorescent primers.
El guardador de hecho ante la dependencia: Revisión de los procedimientos autonómicos y de las declaraciones «bajo su responsabilidad (2009)

La Ley 39/2006, de 14 de diciembre, de Promocion de la Autonomia Personal y Atencion a las personas en situacion de dependencia, consagra un nuevo derecho subjetivo de ciudadania que exige que se haya interesado y resuelto el procedimiento administrativo donde se ventilara el reconocimiento de la dependencia y las prestaciones del Sistema. Revisaremos el protagonismo dispensado al guardador de hecho, toda vez que sin estar prevista su legitimacion activa en la Ley, reglamentos y modelos de solicitud han recogido su declaracion, hecha «bajo su responsabilidad».
Vascular Smooth Muscle α <sub>v</sub> β <sub>3</sub> Integrin Mediates Arteriolar Vasodilation in Response to RGD Peptides (1996)

Arteriolar vasodilation and the resultant increase in blood flow are characteristic vascular responses to tissue injury. The dilatory mediators signaling these responses are incompletely understood. We show that integrin-binding peptides containing the Arg-Gly-Asp (RGD) tripeptide sequence cause immediate and, in some instances, sustained vasodilation when applied to isolated rat cremaster arterioles. The vasodilation is dependent on interaction of the soluble RGD sequence with the alpha v beta 3 integrin expressed by smooth muscle cells in the arteriolar wall. Possible in vivo sources of soluble RGD sequences are fragments of extracellular matrix proteins that are generated after tissue injury. Indeed, protease-generated fragments of denatured collagen type I (a major source of RGD sequences) also cause cremaster arteriolar vasodilation through the alpha v beta 3 integrin. Thus, extracellular matrix protein fragments containing the RGD sequence may act as vascular wound recognition signals to regulate blood flow to injured tissue.
Fundamentos de C (2002)

Este libro explica el lenguaje de programacion c++ segun la norma aprobada hace unos pocos anos por el instituto de normalizacion ANSI. Ha sido hecho pensando en los alumnos de Metodologia y Tecnologia de Programacion II, asignatura de segundo curso de Ingenieria Tecnica en Informatica de Gestion.
A Study of the Effectiveness of the Iron-Chelating Agent Deferoxamine as Vasospasm Prophylaxis in a Rabbit Model of Subarachnoid Hemorrhage (1991)

Abstract The pathogenesis of cerebral vasospasm occurring after subarachnoid hemorrhage (SAH) is unknown. Several lines of experimentation have suggested a free radical mechanism in the etiology of vasospasm. Iron is an important catalyst in the generation of free radicals and lipid peroxides in response to tissue injury. We hypothesize that the elaboration of iron from the subarachnoid clot might result in enhanced generation of free radicals and lipid peroxidation. If so. then treatment with deferoxamine, an iron-chelating compound, might reduce the formation of free radicals and thereby ameliorate vasospasm. This hypothesis was examined in a rabbit model of experimental cerebral vasospasm. New Zealand White rabbits were divided into the following experimental groups: control (normal) animals (n = 7), control animals treated with deferoxamine (n = 3), animals subjected to SAH and killed on Day 2 (n = 7), animals subjected to SAH on Day 2 and treated with deferoxamine (n = 9), animals subjected to SAH killed on Day 3 (n = 7). and animals subjected to SAH on Day 3 and treated with deferoxamine (n = 7). Deferoxamine treatment (50 mg/kg/8 hours) was begun 16 hours before the induction of SAH and continued until the animals were killed by perfusion fixation. The basilar artery caliber was assessed using morphometric techniques. The diameter of the basilar arteries in the control animals was 0.64 ± 0.02 mm. Deferoxamine treatment alone did not alter the artery diameter. SAH resulted in a decrease in basilar artery diameter by 20% on Day 2 and 27% on Day 3. Deferoxamine treatment attenuated the SAH-induced spasm minimally on Day 2 but significantly on Day 3 (Day 3 diameter = 0.60 ± 0.04; P &lt; 0.015). These preliminary results show promise for deferoxamine therapy in the treatment of vasospasm occurring after SAH. These data support the notion that SAH-induced vasospasm is mediated by iron, possibly via the generation of free radicals.
Effectiveness of Disinfectants Against <i>Candida auris</i> and Other <i>Candida</i> Species (2017)

Contaminated surfaces are a suspected source for dissemination of the globally emerging pathogen Candida auris. In laboratory testing, sporicidal and improved hydrogen peroxide disinfectants were highly effective against C. auris, C. glabrata, and C. albicans. The widely used quaternary ammonium disinfectants exhibited relatively poor activity against all of the Candida species. Infect Control Hosp Epidemiol 2017;38:1240-1243.
A 0.026mm<sup>2</sup> capacitance-to-digital converter for biotelemetry applications using a charge redistribution technique (2007)

This paper proposes a direct capacitance-to-digital converter (CDC) for biotelemetry applications. The proposed circuit is based on a charge redistribution technique using a capacitive sensor and a ranging capacitor array. The circuit does not require accurate reference voltages, so it is robust for fluctuation of supply voltage. Output-code range can be dynamically zoomed in arbitrary capacitance range of sensor output by using the ranging capacitor array. An 8-bit converter with an active area of 0.026 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , consuming 0.9 nJ per sample, is demonstrated. The proposed circuit maintains its performance even in the condition of 28% fluctuations in supply voltage. Measurement results of the readout circuit are also demonstrated, which shows that the proposed circuit can work well in the presence of large parasitic capacitances.