gebhart/patrepeval huggingface dataset:
NSAID-induced intestinal damage: are luminal bacteria the therapeutic target? (2008)

suggests that inhibition of both COX-1 and COX-2 is necessary to cause significant GI damage. The importance of PG deficiency in the pathogenesis of NSAIDinduced intestinal damage is confirmed by the finding that administration of exogenous PGs before indomethacin either reduces or eliminates intestinal damage in rats. 91 0 NSAID-induced damage to the intestinal epithelium is set in motion by a direct effect of the drug after oral administration, a persistent local action due to the enterohepatic recirculation of the compound, 11 12 and the systemic effects carried out after its absorption. 5 The initial biochemical local sub-cellular damage is due to the entrance of the usually acidic NSAID into the cell via damage of the brush border cell membrane and disruption of the mitochondrial process of oxidative phosphorylation, with consequent ATP deficiency. 13
Visualization of path expressions in a visual object-oriented database query language (2003)

Path expressions have been accepted for concisely manipulating the nested structures in complex object-oriented query expressions. However, previous visual query languages hardly represent such query expressions in a concise and intuitive way partly due to improper visual representation of path expressions and partly due to lack of well-defined system and semantics of languages. In this paper, we present visual modeling of path expressions in a visual object-oriented database query language called Visual Object-Oriented Query Language (VOQL) which has excellent expressive pourer for sets, simple and intuitive syntax, and well-defined semantics. This is enabled by explicitly specifying the semantics of multi-valued path expressions based on the visual notation capable of representing set relationships in addition to functional relationships. The basic visual constructs called blobs and nested blobs denote sets of objects that path expressions represent while the constructs called binding edges and flattening edges visually simulate the notions of variable binding and dot functions in path expressions respectively. Based on the constructs, the grammar of VOQL defines the syntactic components while the semantics of query expressions are provided by syntax-directed translation to the counterparts in the extended relational calculus. Also, the visual constructs allow modeling of restricted universal quantification with a visual scoping box and effectively represent nested quantification and recursive queries without semantic ambiguities.
Pseudomonas oleovorans monooxygenase-catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring-opening rate exceeding the oxygen-rebound rate (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPseudomonas oleovorans monooxygenase-catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring-opening rate exceeding the oxygen-rebound rateHong Fu, Martin Newcomb, and Chi Huey WongCite this: J. Am. Chem. Soc. 1991, 113, 15, 5878–5880Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ja00015a061https://doi.org/10.1021/ja00015a061research-articleACS PublicationsRequest reuse permissionsArticle Views469Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Performance Analysis of Transmitting MPEG4 over SCTP (2004)

SCTP (stream control transmission protocol) is newly proposed by IE TF SIGTRAN, which is used to transport PSTN NO.7 signals over IP network. This p aper compares SCTP with the existing protocol such as TCP, analyzes its more eff icient transport mechanism for NO.7 and multimedia messages than TCP, and studie s the performance of transmitting MPEG4 video over SCTP protocol. In addition, t he other possible applications and the prospect of SCTP are also described.
Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cells (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cellsPaul M. KraemerCite this: Biochemistry 1971, 10, 8, 1437–1445Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/bi00784a026https://doi.org/10.1021/bi00784a026research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations238LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Silicon micromachined ultrasonic immersion transducers (1996)

Broadband transmission of ultrasound in water using capacitive, micromachined transducers is reported. Transmission experiments using the same pair of devices at 4, 6, and 8 MHz with a signal-to-noise ratio greater than 48 dB are presented. Transmission is observed from 1 to 20 MHz. Better receiving electronics are necessary to demonstrate operation beyond this range. Furthermore, the same pair of transducers is operated at resonance to demonstrate ultrasound transmission in air at 6 MHz. The versatile transducers are made using silicon surface micromachining techniques. Computer simulations confirm the experimental results and are used to show that this technology promises to yield immersion transducers that are competitive with piezoelectric devices in terms of performance, enabling systems with 130 dB dynamic range. The advantage of the micromachined transducers is that they can be operated in high-temperature environments and that arrays can be fabricated at lower cost.
Interatomic potentials for SiO2 (1984)

Interatomic potentials, which include bond-bending terms, allow us to model accurately the properties of α-quartz and the structures of other polymorphs of SiO2.
Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing (2014)

Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-which we set out to test by sequencing individual cells from three subjects diagnosed with secondary acute myeloid leukemia, each of whom had been previously characterized by whole genome sequencing of unfractionated tumor samples. Single-cell mutation profiling strongly supported the clonal architecture implied by the analysis of bulk material. In addition, it resolved the clonal assignment of single nucleotide variants that had been initially ambiguous and identified areas of previously unappreciated complexity. Accordingly, we find that many of the key assumptions underlying the analysis of tumor clonality by deep sequencing of unfractionated material are valid. Furthermore, we illustrate a single-cell sequencing strategy for interrogating the clonal relationships among known variants that is cost-effective, scalable, and adaptable to the analysis of both hematopoietic and solid tumors, or any heterogeneous population of cells.
A study of the secondary effects of hill fertilization (1925)

A field, laboratory, and greenhouse study of secondary effects of hill fertilization was made using several different soils as follows: Carrington loam, Webster silt loam, Grundy silt loam, Knox silt loam, Marion silt loam, and Buckner coarse sand. The effect of hill fertilization on the root development of the corn plant was also investigated.\nAcid phosphate was found to have a more pronounced effect on the hydrogen ion concentration of the soil solution than either ammonium sulfate or potassium chloride. In most cases the first effect of acid phosphate was to increase the acidity of the soil solution. In poorly buffered soils, such as sands or sandy loams, this increased acidity may persist for some time. In other soils the acidity is neutralized very quickly, and sometimes a less acid solution than that of the untreated soil may be produced.\nThe effect of hill fertilization on carbon dioxide production was found to be slight on a loam and silt loam, while a decreased occurred on a sandy soil.
Effects of message style on users' attributions toward agents (1994)

We used a Wizard-of-Oz paradigm to study effects of message style on dialog and on people's mental models of computer agents. People made airline reservations using a simulated reservation agent from which they received one of three message styles: Telegraphic, Fluent, or Anthropomorphic. The agent accepted any kind of language or command input people typed. When people took the initiative, they tended to model their inputs on the computer's messages. They expended more effort in the Anthropomorphic than in the Fluent or Telegraphic conditions. We found no evidence that natural language messages caused higher expectations of intelligence than telegraphic messages.
An Experimental 35-mm Multilayer Stripping Negative Film (1950)

The so-called “three-strip” method is generally considered to give the best results when taking professional color motion pictures. An objection to this method is that it requires the use of a special camera fitted with a beam-splitter prism. This paper describes work that led to the development of a single multilayer negative film which can be used in any standard motion picture camera. After exposure and before development, the two upper layers are wet-stripped separately onto special transfer supports. Thus the single support of the multilayer film bears three color-sensitive emulsions in the following order: a red-sensitive layer next to the support, an intermediate green-sensitive layer, and an upper blue-sensitive layer. The red- and green-sensitive layers, and the green- and blue-sensitive layers are each separated by interlayers which facilitate stripping of the two upper layers. The film has an over-all thickness about the same as standard motion picture negative film. Its speed is such that good negatives of an open landscape can be exposed at f/8 or even f/11. An experimental stripping machine is described which accurately registers the perforations of the two stripped layers with those of the original film on which remains the red-sensitive layer.
[Development of a novel gene therapy using survivin antisense expressing adenoviral vectors]. (2003)

These findings suggest that targeting of survivin using adenoviral antisense vectors may have a potential role in the selective therapy of colon cancer.
Decreased mRNA expression of transcription factor forkhead box F2 is an indicator of poor prognosis in patients with resected esophageal squamous cell carcinoma (2015)

The transcription factor forkhead box F2 (FOXF2) is an evolutionarily conserved DNA-binding protein involved in embryogenesis and metabolism. Although recent studies prove that FOXF2 is a tumor suppressor in various human cancers, the role of FOXF2 in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, samples were collected from 188 ESCC patients, including 33 pairs of tumor and non-tumor tissues, and <i>FOXF2</i> mRNA expression was investigated by quantitative polymerase chain reaction. The results demonstrated that <i>FOXF2</i> mRNA is downregulated in tumor tissues compared to paired non-tumor tissues (P=0.048). The receiver operating characteristic curve analysis indicated 1.2 as a cut-off point and, thus, 125 and 63 tumors were classified as low- and high-level <i>FOXF2</i> mRNA expression, respectively. We observed that low-level <i>FOXF2</i> mRNA expression in the tumors was associated with a higher frequency of lymph node metastasis (P=0.044), an effect further suggested by the multivariate logistic regression analysis (P=0.060). According to the univariate Cox analysis, patients harboring tumors with low-level <i>FOXF2</i> mRNA expression had a significantly increased mortality risk compared to those with high-level expression (hazard ratio=1.700, 95% confidence interval, 1.077-2.681), with 5-year survival rates of 41.1 and 61.9%, respectively. This negative prognostic effect of low-level <i>FOXF2</i> mRNA expression was further validated in the multivariate Cox analysis (P=0.021). The subgroup analysis demonstrated that the effect of <i>FOX2</i> mRNA expression was limited to male patients and those with advanced-stage disease. Taken together, these findings suggest that <i>FOXF2</i> may be an anti-oncogene for ESCC and decreased <i>FOXF2</i> mRNA expression is associated with a poor prognosis in patients with ESCC.
A System for the Excitation of Pure Natural Modes of Complex Structure (1950)

Analogy is drawn between analytical and experimental approaches to the evaluation of structural dynamic behavior, pointing out the relationship between method complexity and adequacy of results. The theory, construction, and operation of a system using 24 shakers controlled from a console in the systematic excitation of pure natural modes are described. Practical operation is made feasible by the coordinated display of the force and resultant velocity a t each shaker station, together with a system for orderly discriminatory adjustment by the operator, which is analogous to a mathematical iteration. Sample laboratory and full-scale data are shown.
An Amino Acid Polymorphism in Histidine-rich Glycoprotein (HRG) Explains 59% of the Variance in Plasma HRG Levels (1995)

A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual environmental factors of 27%. These results are remarkably similar to the results found in a previous parent-twin study in which a heritability of 69% and an effect of random environment of 31% was found. The overall genetic influence in the present study can be subdivided into an effect of 59% by the HRG phenotype and 11% by residual genetic factors. The influence of the HRG phenotype of 59% can entirely be explained by adding up the effect of the two alleles that make up the phenotype. These results indicate a codominant inheritance pattern of HRG levels in which the genetic influences can almost completely be ascribed to the additive effect of the di-allelic HRG locus whereas only a small part is due to other loci.
Damping of Wind Turbine Tower Oscillations through Rotor Speed Control (2007)

To enable wind turbines to produce power under great variety of wind conditions a sophisticated control system is needed. Wind turbine system is highly nonlinear and its dynamic changes rapidly with the change of wind speed. Besides this, wind turbine mechanical structure is very flexible due to its great height and tends to oscillate. All this makes the design of wind turbine control system very demanding task. In his paper three controller design methods are compared. It is shown how with adequate controller design it becomes possible to control the wind turbine under various operating conditions reducing the structural oscillations at the same time
Rapid isolation of functionally intact pancreatic islets from mice and rats by percollTM gradient centrifucation. (1980)

A discontinuous gradient of Percoll was used to effectively separate islets of Langerhans from collagenase digested pancreas from mice and rats. Percoll isolated islets and islets isolated by direct hand-picking from the pancreatic digest were maintained in tissue culture. Percoll isolation of islets did not affect glucose-stimulated insulin release from islets cultured for one week nor the ability of islets from newborn rats to incorporate 3H-thymidine into DNA. Centrifugation in Percoll is an efficient method to isolate functionally intact pancreatic islets.
Time-sensitive Dirichlet process mixture models (2018)

Abstract: "We introduce Time-Sensitive Dirichlet Process Mixture models for clustering. The models allow infinite mixture components just like standard Dirichlet process mixture models. However they also have the ability to model time correlations between instances."
La Calidad desde Siempre. (1995)

INGEMAS, S.A. empresa privada fundada en Gijon en 1979 y perteneciente al Grupo Babkok Espana desde 1987, desarrolla actividades de Ingenieria, Consultoria y Gestion en un amplio espectro de disciplinas tecnicas: Mineria, Manutencion, Energia y Medio Ambiente. Posee un perfil tecnologico de Main Contractor como Ingenieria de desarrollo con capacidad tecnologica para afrontar en solitario proyectos de manutencion, tratamiento de minerales, tratamiento de aguas industriales, cogeneracion y estructuras especiales.
Identification of novel cyclin-dependent kinases interacting with the CKS1 protein of Arabidopsis (2001)

The SUC1/CKS1 proteins interact with cyclin-dependent kinases (CDKs) and play an essential, but yet not entirely resolved, role in the regulation of the cell cycle. With the Arabidopsis thaliana CKS1At protein as bait in a two-hybrid screen, two novel Arabidopsis CDKs, Arath;CDKB1;2 and Arath;CDKB2;1, were isolated. A closely related homologue of Arath;CDKB2;1 was discovered in the databases and was nominated Arath;CDKB2;2. Transcript analysis of the five known Arath;CDKA and Arath;CDKB genes revealed that they all had the highest expression in flowers and cell suspensions. Differences in the expression patterns in roots, leaves and stems suggest unique roles for each CDK.
Survival After Death and the Vindication of Belief (1970)

In the previous chapter we assumed that a belief in immortality entails some kind of survival after death. We examined various kinds of survival which might be involved, and found that they all involve serious logical and empirical difficulties. In many ways, we saw that the notion of bodily survival of a physical kind after death is central to the belief that the same person lives again after his death. On the other hand, this notion inherits as many difficulties as the notion of disembodied existence after death or the notion of non-material bodies surviving death. And, as Professor Geach admits, there is no philosophical reason to expect that at some future date the graves will yield their dead. Nevertheless, Geach says, this is the faith that Christians have : That faith is not going to be shaken by inquiries about bodies burned to ashes or eaten by beasts ; those who might well suffer such death in martyrdom were those who were most confident of a glorious reward in the resurrection. One who shares that hope will hardly wish to take out an occultistic or philosophical insurance policy, to guarantee some sort of survival as an annuity, in case God’s promise of resurrection should fail. ([9] p. 29)
Multiband transport in bilayer graphene at high carrier densities (2011)

We report a multiband transport study of bilayer graphene at high carrier densities. Employing a poly(ethylene)oxide-CsClO${}_{4}$ solid polymer electrolyte gate we demonstrate the filling of the high-energy subbands in bilayer graphene samples at carrier densities $|n|\ensuremath{\geqslant}2.4\ifmmode\times\else\texttimes\fi{}{10}^{13}$ cm${}^{\ensuremath{-}2}$. We observe a sudden increase of resistance and the onset of a second family of Shubnikov--de Haas (SdH) oscillations as these high-energy subbands are populated. From simultaneous Hall and magnetoresistance measurements, together with SdH oscillations in the multiband conduction regime, we deduce the carrier densities and mobilities for the higher-energy bands separately and find the mobilities to be at least a factor of 2 higher than those in the low-energy bands.
Cooperative Multi-sensor Multi-vehicle Localization in Vehicular Adhoc Networks (2015)

Intelligent Transportation System (ITS) is an important application domain for information reuse and integration. Efficient integration and deployment of information and communication technologies (ICT) can potentially reduce travel time and emission, improve usage of parking and public spaces, offer personalized travel related services, and more importantly, improve safety for drivers and pedestrians in large municipalities. Personalized travel related services and recommendation systems rely mainly on precise identification of position of the vehicles. In this paper we propose a cooperative multi-sensor multi-vehicle localization algorithm with high accuracy for terrestrial vehicles. Noisy observations in the form of GPS coordinates of nearby vehicles as well as inter-vehicle distance measurements are assumed to be available. These heterogeneous sources of information are fused together and used to estimate the number and motion model parameters of the vehicles in the field. The problem is formulated in the context of Bayesian framework and vehicle locations are estimated via a Sequential Monte-Carlo Probability Hypothesis Density (SMC-PHD) filter. Given that the GPS data and inter-vehicle distance measurements are available except for short periods of time, simulation results indicate that the proposed algorithm provides approximately threefold improvement in location accuracy compared to that achieved with GPS.