gebhart/patrepeval huggingface dataset:
Galectin-8 Induces Apoptosis in Jurkat T Cells by Phosphatidic Acid-mediated ERK1/2 Activation Supported by Protein Kinase A Down-regulation (2009)

Galectins have been implicated in T cell homeostasis playing complementary pro-apoptotic roles. Here we show that galectin-8 (Gal-8) is a potent pro-apoptotic agent in Jurkat T cells inducing a complex phospholipase D/phosphatidic acid signaling pathway that has not been reported for any galectin before. Gal-8 increases phosphatidic signaling, which enhances the activity of both ERK1/2 and type 4 phosphodiesterases (PDE4), with a subsequent decrease in basal protein kinase A activity. Strikingly, rolipram inhibition of PDE4 decreases ERK1/2 activity. Thus Gal-8-induced PDE4 activation releases a negative influence of cAMP/protein kinase A on ERK1/2. The resulting strong ERK1/2 activation leads to expression of the death factor Fas ligand and caspase-mediated apoptosis. Several conditions that decrease ERK1/2 activity also decrease apoptosis, such as anti-Fas ligand blocking antibodies. In addition, experiments with freshly isolated human peripheral blood mononuclear cells, previously stimulated with anti-CD3 and anti-CD28, show that Gal-8 is pro-apoptotic on activated T cells, most likely on a subpopulation of them. Anti-Gal-8 autoantibodies from patients with systemic lupus erythematosus block the apoptotic effect of Gal-8. These results implicate Gal-8 as a novel T cell suppressive factor, which can be counterbalanced by function-blocking autoantibodies in autoimmunity.
Sensor and Actuator Requirements for Heavy Duty Diesels (1983)

<div class="htmlview paragraph">The current trend from hydromechanical to computer based engine controls is creating the need for high production volume, low cost, electronic sensors and actuators. These components must match the reliability and durability of the engine to which they are mounted. This paper outlines the heavy duty diesel engine environment and uses the development of a throttle position sensor as an example of the unique specifications required for some components.</div>
Comparison of WKB calculations and experimental results for three-dimensional cochlear models (1979)

The WKB asymptotic method is applied to the calculation of cochlear models with square scala cross section, for which the fluid motion is fully three dimensional. The analysis begins with the exact solution for wave propagation in a duct with constant properties. This solution is somewhat tedious but straightforward, since it requires a Fourier series expansion across the duct. Then with the formulation of Whitham [Linear and Nonlinear Waves (Wiley, New York, 1974)], the approximate solution is readily generated for the duct with properties which vary slowly along the length. Numerical calculations are carried out for the experimental models of Cannel [Ph.D. thesis, Univ. of Warwick (1969)] and Helle [Dr.-Ing. disser., Technische Univ., Müchen (1974)] who furnish quantitative details of both "basilar membrane" response and model parameters. Without any free parameters for adjusting, the present WKB solution shows quite satisfactory agreement with the experimental model results. Computer time is reasonable; the calculation of displacement envelope and phase at a number of stations along the cochlea for a given frequency requires only one second of CPU time. Thus the credibility and practically of the approach is established for the investigation of yet more realistic and more elaborate cochlear models.
Diabetes Mellitus and Periodontal Disease (1967)

One hundred and eighty-nine dentulous patients with diabetes mellitus and sixty-four patients believed free of diabetes were examined for periodontal disease. Certain variables were measured and related by computer analysis to the degree of observed gingival pathology. The findings indicate that the prevalence and severity of periodontal disease are increased in the diabetic patient. In addition, the periodontal index was related in positive fashion to age, duration of known diabetes, diabetic complications, and variation of blood sugar levels.
Kinesin spindle protein Inhibitors as anticancer agents (2006)

Kinesin spindle protein (KSP), or Hs Eg5, is a member of the kinesin superfamily of molecular motor proteins that utilise the energy generated from the hydrolysis of ATP to transport vesicles, organelles and microtubules. KSP plays essential roles in mitotic spindle function and its inhibition prevents normal bipolar spindle formation, leading to mitotic arrest and subsequently to apoptosis of cells. Therefore, KSP inhibitors have potential as novel anticancer therapeutics. Since the discovery of monastrol in 1999, many types of KSP inhibitors have been reported. This review describes the mechanism of action and development of different types of KSP inhibitors.
A Study on Work Life Balance (With Special Reference to Executives Working at NTPC, Korba) (2011)

Work life balance is about people having a measure of control over when, where and they work. Work life balance refers to a person's control over the conditions in their work place. It is accomplished when an individual feels duly satisfied about their personal life and their paid occupation. It mutually benefits, the individual business and society when a person's personal life is balanced with his or her job. The work life balance strategy offer a variety of means to reduce stress levels and increase job satisfaction in the employee while enhancing business benefits for the employer. This paper mainly discusses the balance between the work life and personal life. It mainly deals with how to maintain balance between personal life and professional life of executives working at NTPC, Korba
Modeling of dielectric barrier discharge plasma actuator in air (2008)

A detailed physical model for asymmetric dielectric barrier discharge (DBD) in air at low voltages (1.5–2 kV) is developed. Modeling of DBD with an applied sinusoidal voltage is carried out in two dimensions. The leading role of charging the dielectric surface by electrons in the cathode phase is shown to be critical, acting as a harpoon that pulls positive ions forward and accelerates the gas in the anode phase. The positive ion motion back toward the exposed electrode is shown to be a major source of inefficiency in the sinusoidal or near-sinusoidal voltage cases. Based on understanding of the DBD physics, an optimal voltage waveform is proposed, consisting of high repetition rate, short (a few nanoseconds in duration), negative pulses combined with a positive dc bias applied to the exposed electrode.
Flexible and Bio‐Based Nonisocyanate Polyurethane (NIPU) Foams (2016)

The amine cure of cyclic carbonate blends, derived from renewable resources and carbon dioxide, in the presence of a liquid fluorohydrocarbon as physical blowing agent with no ozone depletion potential, enables the facile tailoring of flexible bio‐based nonisocyanate polyurethane (NIPU) foams. Unlike conventional PU foams, neither isocyanates nor phosgene or aromatic amines are required as intermediates in NIPU foaming. Typically, rigid cyclic carbonates such as carbonated trimethylolpropane glycidylether (TMPGC) are blended together with the corresponding flexible cyclic carbonate such as ethoxylated TMPGC (EO‐TMPGC) which lowers monomer viscosity and reactivity. This is reflected by higher pot life and gelation times for the cure with hexamethylene diamine (HMDA), improving NIPU foam processing. With increasing EO‐TMPGC content, rigid TMPGC/HMDA‐NIPU foams are rendered flexible and soft, as verified by simultaneously declining storage modulus and glass transition temperature. In this NIPU foam family, the TMPGC/EO‐TMPGC (60 wt%/40 wt%) blend cured with HMDA in the presence of Solkane 365/227 affords flexible NIPU foams exhibiting low density, very good mechanical hysteresis, and tailored hardness, meeting the demands of various applications like automotive seating. Emission tests confirm the absence of critical compounds mentioned in the global automotive declarable substance list. image
Experimental comparison between conventional and hybrid long-range surface plasmon waveguide bends (2008)

We report on the characterization of long-range surface plasmon waveguide bends at telecom wavelengths $(\ensuremath{\lambda}=1550\phantom{\rule{0.3em}{0ex}}\mathrm{nm})$. The structures consist of a thin Au stripe embedded in a transparent polymer film. When the polymer thickness is larger than the lateral extension of the plasmon, the stripe sustains a conventional long-range mode; in the opposite case, the mode is hybrid because its field distribution is confined by total internal reflection in the dielectric cladding. This hybridization increases the damping by absorption but dramatically reduces the radiation loss that occurs for curved geometries, such as bends. Our results are supported quantitatively by full-wave finite-element simulations.
Modeling Transient Vibrations While Drilling Using a Finite Rigid Body Approach (2010)

Abstract Vibrations are a common contributor to premature drillstring failure. The need for a better understanding of the phenomenon has driven the implementation of real-time downhole drilling mechanics measurements. As the costs associated with poor drilling performance and equipment failures increase, so does the impact of improving the modeling of these vibrations. The onset of downhole vibrations is complex and sensitive to a wide range of factors, some of which are difficult to quantify within a typical drilling environment. Examples of these factors are the friction factor at contact points, drillstring component imbalance and rock properties and their variability. Field experience has shown that the identification of resonant conditions using frequency domain modal analysis is of value; however, additional insight can be gained through the use of a transient vibration analysis. This paper describes a numerical modeling tool developed to enhance understanding of the transient dynamics undergone by a drillstring during the drilling operation. A Finite Rigid Body (FRB) approach has been chosen for modeling simplicity, computational cost, and physical relevance of the computed results. This approach can be used to incorporate important transient features characteristic of a drilling operation, such as the bit-rock interaction and the interaction of the drillstring with the borehole wall, as well as the relevant dynamics introduced by drilling tool components such as mud motors and bit steering devices. A number of examples and case studies illustrate the capabilities of the modeling tool.
Dimerization of the molybdenum complex [(SO4)Mo(O)(.mu.-S)2Mo(O)(SO4)]2- dianions stabilized by a quadruply bridging sulfate ligand and intramolecular hydrogen bonding by the [(CH3)2NH2]+ cations. Structures of the [(CH3)2NH2]6-x(Et4N)x[{(SO4)Mo(O)(.mu.-S)2Mo(O)(SO4)}2(SO4)] aggregates (x = 1, 2, 2.5) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDimerization of the molybdenum complex [(SO4)Mo(O)(.mu.-S)2Mo(O)(SO4)]2- dianions stabilized by a quadruply bridging sulfate ligand and intramolecular hydrogen bonding by the [(CH3)2NH2]+ cations. Structures of the [(CH3)2NH2]6-x(Et4N)x[{(SO4)Mo(O)(.mu.-S)2Mo(O)(SO4)}2(SO4)] aggregates (x = 1, 2, 2.5)Chang G. Kim and Dimitri CoucouvanisCite this: Inorg. Chem. 1993, 32, 11, 2232–2233Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ic00063a004https://doi.org/10.1021/ic00063a004research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
RegPrecise 3.0 – A resource for genome-scale exploration of transcriptional regulation in bacteria (2013)

RegPrecise 3.0 gives access to the transcriptional regulons reconstructed in bacterial genomes. Analytical capabilities include exploration of: regulon content, structure and function; TF binding site motifs; conservation and variations in genome-wide regulatory networks across all taxonomic groups of Bacteria. RegPrecise 3.0 was selected as a core resource on transcriptional regulation of the Department of Energy Systems Biology Knowledgebase, an emerging software and data environment designed to enable researchers to collaboratively generate, test and share new hypotheses about gene and protein functions, perform large-scale analyses, and model interactions in microbes, plants, and their communities.
GDQA : Graph Driven Question Answering System (2004)

In this paper, we present a question answering system developed for NTCIR-4 in detail. Our question answering system, GDQA, employs a new text retrieval algorithm specialized for QA and a new algorithm for sorting the answer candidates. Using our new algorithm for text retrieval, articles containing the asnwer for the question can be retirieved with high precision. Our algorithm for sorting the answer candidates uses the graph structure based on the result of the dependency analysis of retrieved articles. With this sorting algorithm, GDQA can present the correct answer in a higher rank than the other candidates.
Ensemble calibration for the spectral quantitative analysis of complex samples (2017)

Abstract Ensemble strategies have gained increasing attention in multivariate calibration for quantitative analysis of complex samples. The aim of ensemble calibration is to obtain a more accurate, stable, and robust prediction by combining the predictions of multiple submodels. The generation and calibration of the training subsets, as well as the integration of the submodels, are three keys to the success of ensemble calibration. Many training subset generating and submodel integrating strategies have been developed to form numerous ensemble calibration methods for improving the performance of the basic calibration method. This contribution focuses on the recent ensemble strategies in relation to calibration, especially the ensemble modeling for quantitative analysis of complex samples. The limitations and perspectives of ensemble strategies are also discussed.
Utilizing stray capacitances of a litz wire (2005)

In power electronics applications, litz wire is widely used for reducing ohmic losses due to skin- and proximity effect eddy currents. Litz wire also introduces stray capacitance that can be utilized in the design of such devices as niters and inverting, matching and balun transmission line transformers (TLTs). This paper focuses on a set of solutions that is obtained through finite element modeling for predicting the per unit length capacitance as a function of the fractional thickness of the strand insulation, its relative permittivity, and the number of strands used in a litz wire conductor. A simple statistical approach is used to account for the unknown distribution of strand position along the lengths of litz bundles, and measured results of prototype samples are presented. Prototype structures are built using litz wire and their frequency dependent characterization is presented.
A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domains (1997)

We have used a rat pachytene spermatocyte cDNA expression library to clone TBP-1 (for tat-binding protein-1; designated rat testis TBP-1 [rtTBP-1]), a new member of the family of putative ATPases associated with the 26S proteasome complex. The 1.63 kb rtTBP-1 cDNA encodes a 49 kDa protein with 99% amino acid identity to human TBP-1 protein. rtTBP-1 protein contains a heptad repeat of six leucine-type zipper fingers at the amino terminal end and highly conserved ATPase and DNA/RNA helicase motifs towards the carboxyl terminal region. Chromatofocusing fractionation of rat testis sucrose extracts demonstrates that the encoded product, recognized by an antiserum raised to the first 196 amino acids of human TBP-1, consists of a protein triplet with a molecular mass range of 52-48 kDa and acidic pI (5.0-5.9). An identical immunoreactive triplet was detected by immunoblotting in extracts of fractionated pachytene spermatocytes, round spermatids and epididymal sperm. In situ hybridization using digoxigenin-labeled antisense RNA probes shows a predominant distribution of specific mRNA in the seminiferous epithelial region occupied by elongating spermatids and primary spermatocytes. Indirect immunofluorescence and immunogold electron microscopy studies show that rtTBP-1 immunoreactive sites colocalize with alpha-tubulin-decorated manchettes of elongating spermatids. In addition, rtTBP-1 immunoreactivity was detected in fibrillar and granular cytoplasmic bodies typically observed in spermatocytes and spermatids as well as in association with paraaxonemal mitochondria and outer dense fibers of the developing spermatid tail. Results of this study indicate that rtTBP-1 is a member of the highly evolutionary conserved TBP-1-like subfamily of putative ATPases, sharing regions of identity-including ATP-binding sites-with several subunits of the 26S proteasome, known to be involved in the ATP-dependent degradation of ubiquitin-conjugated proteins.
Reliable hot‐spot classification in 10 ms using ultra‐fast lock‐in thermography (2009)

Abstract We propose and demonstrate a reliable and non‐destructive spatially resolved measurement technique for ultra‐fast hot‐spot classification of solar cells. The method can deliver quantitative images of the local heat dissipation in hot‐spots in measurement times below 10 ms. The high accuracy and sensitivity allow for reliable hot‐spot testing and provide the basis for a reliable classification of solar cells into different hot‐spot categories. The method can be applied to wafer‐based silicon solar cells and in principle also to thin‐film solar cells of all material compositions. This paper explains the measurement principle, gives a detailed step‐by‐step description of viable automated evaluation procedures, and assesses the sensitivity and accuracy of the method. Copyright © 2009 John Wiley & Sons, Ltd.
Second-harmonic generation in aromatic organic compounds (1987)

The second-harmonic generation efficiencies of a large number of aromatic organic compounds are presented. The second-harmonic data from a series of benzophenone and pyridine derivatives are discussed in detail. Specifically, 4-aminobenzophenone and 4-benzoylpyridine are shown to be of potential interest as frequency doublers for semiconductor lasers.
Applications of an automated apparatus for two‐dimensional electrophoresis, Model TEP‐1, for microsequence analyses of proteins (1992)

Two-dimensional electrophoresis has become a rapid and powerful separation method for the preparation of samples for sequence analysis depending on the development of automated microsequencers accompanied by a blotting technique. We have constructed an automated apparatus for two-dimensional electrophoresis, Model TEP-1, which allows precise analytical runs under computer-control with a fully automated transfer from the first- to the second-dimensional gel. In the present paper we describe several applications of TEP-1 followed by blotting and sequencing to reveal the primary structure of proteins in a complex mixture. Several known and unknown proteins were analyzed. Enzymatic digests of proteins could be directly applied onto the TEP-1, in which a gel of lower molecular weight proteins was used as the second dimension. Subsequent blotting and sequencing provided internal sequence information. The use of TEP-1, followed by blotting, provides spots containing ca. 10-100 pmol protein. These figures permitted the identification of 10-40 amino acid residues from the N-terminus. The TEP-1 provides a simple and rapid separation of complex mixtures obtained from natural sources and chemical, biological or genetic products.
β‐Lactame mit über Heteroatome gebundenen Substituenten (1974)

Abstract 4‐(Acyloxy)azetidin‐2‐one sind aus Vinylestern und Chlorsulfonylisocyanat zugänglich. Die glatt ablaufende nucleophile Verdrängung der Acyloxygruppe am C‐4 liefert 4‐Thio‐, 4‐ (Aryloxy)‐, 4‐(Alkyloxy); 4‐(Arylsulfonyl)‐, 4‐(Alkylsulfonyl)‐, 4‐Azido‐ und 4‐Phthalimido‐ P‐lactame. Die über N,O oder S gebundenen Substituenten in 4‐Stellung sind unter bestimmten Bedingungen erneut austauschbar. Dieser Austausch erfolgt unter Racemisierung.
A Web Architecture to Support Collaborative Training Content Development and Evaluation (2006)

Development of web-based training tools requires the collaboration of instructional system designers, domain subject matter experts, web developers, and software engineers. This paper discusses the enhancements to a web-based training architecture to enable collaboration among these contributors. The enhancements allow domain subject matter experts to view the training material and to provide feedback. The paper provides an illustrative example where the system was used during the development of a web-based training tool for flight dispatchers.
Preparation of Indoles from α-Aminonitriles:  A Short Synthesis of FGIN-1-27 (2006)

Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically active compounds.
A high performance MEMS based digital-output gyroscope (2013)

In this work, the architecture, and measurements results of an ultra-low noise closed-loop force feedback gyroscope, with superior bias instability, are presented. The MEMS is interfaced to a highly programmable capacitive interface ASIC, constructing a complete sensor module with a digital-output. Measurements results indicate the superior performance of the gyroscope, with a bias instability of 1°/hr, a noise floor of 1.3m/s/√Hz, and a full-scale range of ±300°/s, while consuming 25mA from a 5V supply.
Further Explorations into the Synthesis of Dehydro<i>‐Hedione</i><sup>®</sup> (2013)

Abstract Dehydrohedione (DHH) 1 may be obtained in 20% overall yield by a Reformatsky reaction with enone methyl ether 3b , followed by acidic workup of the crude reaction mixture. Alternatively, epoxidation (3‐chloroperbenzoic acid, CH 2 Cl 2 , 84% yield) of the tertiary allyl alcohol derivative 4 affords a 1 : 2 mixture of 8a and 8b . The latter epoxy ester 8b may also be obtained stereoselectively either from 4 ( t BuO 2 H, [Mo(CO) 6 ], 1,2‐dichloroethane, 70°, 62% yield; or t BuO 2 H, [VO(acac) 2 ], decane, 20°, 92% yield), or from 5 (AcOMe, LiN(SiMe 3 ) 2 , THF, −78°, 84–87%). BF 3 ⋅Et 2 O‐Catalyzed cascade rearrangement and OH elimination of 8a afford selectively DHH 1 in 88% yield. The cis disposition of the side chains of the weakly odoriferous hedione‐like analogues 2b and 2c was maintained by means of either an epoxy or a cyclopropane moiety.