gebhart/patrepeval huggingface dataset:
Efficient Red‐Emissive Organic Crystals with Amplified Spontaneous Emissions Based on a Single Benzene Framework (2017)

Abstract Red‐emissive fluorophores generally consist of large π‐extended systems and thus encounter the problem of serious fluorescence quenching in the solid state. A series of structurally simple compounds 2,5‐bis(alkylamino)terephthalates 1 a – c are reported that consist of a very small π‐system (only a single benzene) but display efficient red emission in crystals. Crystal 1 a having a molecular weight of only 252 g mol −1 shows red emission with the maximum of 620 nm and a fluorescence quantum yield of 0.40. The unique emission property of crystal 1 a is mainly because of the planarization of skeleton dominated by the strong intramolecular hydrogen bonds and the packing structure with negligible π–π interactions contributed by the mini π‐system. Moreover, besides efficient red emission, high crystallinity with co‐planar facets endows crystal 1 a with significant amplified spontaneous emission.
Cyanophycin-degrading bacteria in digestive tracts of mammals, birds and fish and consequences for possible applications of cyanophycin and its dipeptides in nutrition and therapy (2009)

The biodegradability of CGP by gut flora provides a first confirmation for the potential applications of CGP and its dipeptides in nutrition and therapy as highly bio-available sources for arginine, lysine, aspartate and possibly also other amino acids.
Long-term haemodynamic evaluation of aortic pericardial xenograft. (1978)

Haemodynamic studies were performed in 30 patients at a mean interval of 43.4 (range 27 to 59) months after aortic valve replacements with pericardial xenografts. Five valve sizes--19, 21, 23, 25, and 27 mm annulus diameter--were used. Of these 30 patients, 16 had preoperative haemodynamic investigations. Comparison of the pre- and postoperative data showed a marginal but significant increase in cardiac output (P less than 0.05). There was a significant reduction in the pulmonary wedge and left ventricular end-diastolic pressures at rest and on exercise (P less than 0.05 and P less than 0.01). At the postoperative study the mean peak systolic gradient was 8.3 mmHg at rest and 12.3 mmHg on exercise in patients with the smallest xenograft inserted (19 mm) and decreased with each corresponding increase in graft size, so that across the 27 mm graft it was hardly measurable. The calculated xenograft surface area ranged from 1.1 to 2.1 cm2 at rest and 1.3 to 2.4 cm2 during exercise. Aortic root angiography showed competent valves in all 30 patients, but a grade 1 to 2 perivalvular leak was shown in 8 patients. This long-term study has indicated significant circulatory improvement and very small transvalvular gradients in patients with aortic pericardial xenografts.
Liraglutide, a once‐daily human GLP‐1 analogue, improves pancreatic B‐cell function and arginine‐stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus (2008)

Fourteen weeks of treatment with liraglutide showed improvements in first- and second-phase insulin secretion, together with improvements in arginine-stimulated insulin secretion during hyperglycaemia.
High-speed 32-channel optical wavelength selector using PLC hybrid integration (2003)

We have developed a new high-speed 32-channel optical wavelength selector (OWS) with gate drivers using PLC hybrid integration. It has excellent characteristics consisting of a low insertion loss of 2.3 dB, a low cross talk of -46 dB and the error-free optical wavelength selection of 10-Gbit/s optical signal.
Optimal Contracts in a Continuous-Time Delegated Portfolio Management Problem (2003)

This article studies the contracting problem between an individual investor and a professional portfolio manager in a continuous-time principal-agent framework. Optimal contracts are obtained in closed form. These contracts are of a symmetric form and suggest that a portfolio manager should receive a fixed fee, a fraction of the total assets under management, plus a bonus or a penalty depending upon the portfolio's excess return relative to a benchmark portfolio. The appropriate benchmark portfolio is an active index that contains risky assets where the number of shares invested in each asset can vary over time, rather than a passive index in which the number of shares invested in each asset remains constant over time.
Dimensions of fatigue in different working populations (2000)

Perceived fatigue related to work has often been measured in one dimension. The main purpose of the present study was to validate a proposed five-factor model of perceived fatigue in a new sample. 597 persons, employed in five occupations with different types of work loads, rated their fatigue after work. The ratings were subjected to analyses of linear structural equation models. The results suggest a slightly revised model for perceived fatigue, still with the five dimensions: Lack of energy, Physical exertion, Physical discomfort, Lack of motivation and Sleepiness. As expected, the rating profiles describing fatigue states differed between the five occupations. On the basis of these results, a revised version of the Swedish Occupational Fatigue Inventory (SOFI) is presented.
Cerebral Blood Flow Measurements by Magnetic Resonance Imaging Bolus Tracking: Comparison with [<sup>15</sup>O]H<sub>2</sub>O Positron Emission Tomography in Humans (1998)

In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using magnetic resonance (MR) bolus tracking was compared with [(15)O]H2O positron emission tomography (PET). The method yielded parametric CBF images with tissue contrast in good agreement with parametric PET CBF images. Introducing a common conversion factor, MR CBF values could be converted into absolute flow rates, allowing comparison of CBF values among normal subjects.
Long-Term Intravenous Treatment of Pompe Disease With Recombinant Human α-Glucosidase From Milk (2004)

Our study shows that a safe and effective medicine can be produced in the milk of mammals and encourages additional development of enzyme replacement therapy for the several forms of Pompe disease. Restoration of skeletal muscle function and prevention of pulmonary insufficiency require dosing in the range of 20 to 40 mg/kg/week. The effect depends on residual muscle function at the start of treatment. Early start of treatment is required.
Study of three solvates of sulfamethazine (2017)

Three solvates for sulfamethazine (SMT) are reported. The solvent interacts with SMT in a strong hydrogen bonding network imparting stability to the solvate structure.
Role of Molecular Anchor Groups in Molecule-to-Semiconductor Electron Transfer (2006)

The dynamics of heterogeneous electron transfer (ET) from the polycyclic aromatic chromophore perylene to nanostructured TiO2 anatase was investigated for two different anchor groups with transient absorption spectroscopy in an ultrahigh vacuum. Data from ultraviolet photoelectron spectroscopy and from linear absorption spectroscopy showed that the donor state of the chromophore was located around 900 meV above the lower edge of the conduction band. With the wide band limit fulfilled the rate of the heterogeneous ET reaction was only controlled by the strength of the electronic coupling and not reduced by Franck-Condon factors. Two different time constants for the electron transfer, i.e., 13 and 28 fs, were measured with carboxylic acid and phosphonic acid as the respective anchor groups. The difference in the ET time constants was explained with the different extension of the donor orbital onto the respective anchor group to reach the empty electronic states of the semiconductor. The time constants were extracted by means of a simple rate equation model. The validity of applying this model on this ultrafast time scale was verified by comparing the rate equation model with an optical Bloch equation model.
Software quality prediction using mixture models with EM algorithm (2002)

The use of the statistical technique of mixture model analysis as a tool for early prediction of fault-prone program modules is investigated. The expectation-maximum likelihood (EM) algorithm is engaged to build the model. By only employing software size and complexity metrics, this technique can be used to develop a model for predicting software quality even without the prior knowledge of the number of faults in the modules. In addition, Akaike Information Criterion (AIC) is used to select the model number which is assumed to be the class number the program modules should be classified. The technique is successful in classifying software into fault-prone and non fault-prone modules with a relatively low error rate, providing a reliable indicator for software quality prediction.
Effect of iodine incorporation on the electrical conductivity of films of nickel phthalocyanine (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of iodine incorporation on the electrical conductivity of films of nickel phthalocyanineW. A. Orr and S. C. DahlbergCite this: J. Am. Chem. Soc. 1979, 101, 11, 2875–2877Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/ja00505a012https://doi.org/10.1021/ja00505a012research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Suppressive effects of Lithospermum erythrorhizon extracts on lipopolysaccharide-induced activation of AP-1 and NF-κB via mitogen-activated protein kinase pathways in mouse macrophage cells (2008)

A variety of anti-inflammatory agents have been shown to exert chemopreventive activity via targeting of transcription factors such as NF-kappaB and AP-1. Lithospermum erythrorhizon (LE) has long been used in traditional oriental medicine. In this study, we demonstrated the inhibitory effects of LE extracts on lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines. As an underlying mechanism of inhibition, LE extracts reduced LPS-induced transactivation of AP-1 as well as NF-kappaB in mouse macrophage cells. Electrophoretic mobility shift assays indicated that LE extracts inhibited the DNA binding activities of AP-1 and NF-kappaB. In addition, phosphorylation of IkappaB-alpha protein was suppressed by LE extracts. Moreover, LE extracts inhibited c-Jun N-terminal kinase and extracellular signal-regulated signaling pathways. Our results suggest that the anti-inflammatory activity of LE extracts may be mediated by the inhibition of signal transduction pathways that normally lead to the activation of AP-1and NF-kappaB. These inhibitory effects may be useful for chemoprevention of cancer or other chronic inflammatory diseases.
Cell cycle-dependent transcriptional and proteolytic regulation of FtsZ in Caulobacter (1998)

In the differentiating bacterium Caulobacter crescentus, the cell division initiation protein FtsZ is present in only one of the two cell types. Stalked cells initiate a new round of DNA replication immediately after cell division and contain FtsZ, whereas the progeny swarmer cells are unable to initiate DNA replication and do not contain FtsZ. We show that FtsZ expression is controlled by cell cycle-dependent transcription and proteolysis. Transcription of ftsZ is repressed in swarmer cells and is activated concurrently with the initiation of DNA replication. At the end of the DNA replication period, transcription of ftsZ decreases substantially. We show that the global cell cycle regulator CtrA is involved in the cell cycle control of ftsZ transcription. CtrA binds to a site that overlaps the ftsZ transcription start site. Removal of the CtrA-binding site results in transcription of the ftsZ promoter in swarmer cells. Decreasing the cellular concentration of CtrA increases ftsZ transcription and conversely, increasing the concentration of CtrA decreases ftsZ transcription. Because CtrA is present in swarmer cells, is degraded at the same time as ftsZ transcription begins, and reappears when ftsZ transcription decreases at the end of the cell cycle, we propose that CtrA is a repressor of ftsZ transcription. We show that proteolysis is an important determinant of cell type-specific distribution and cell cycle variation of FtsZ. FtsZ is stable when it is synthesized and assembles into the cytokinetic ring at the beginning of the cell cycle. After the initiation of cell division, the rate of FtsZ degradation increases as both the constriction site and the FtsZ ring decrease in diameter. When ftsZ is expressed constitutively from inducible promoters, the abundance of FtsZ still varies during the cell cycle. The coupling of transcription and proteolysis to cell division ensures that FtsZ is inherited only by the progeny cell that will begin DNA replication immediately after cell division.
Basic Well Log Analysis for Geologists (1982)

As logging tools and interpretive methods are developing in accuracy and sophistication, they are playing an expanded role in the geological decision–making process. Today, petrophysical log interpretation is one of the most useful and important tools available to a petroleum geologist.Besides their traditional use in exploration to correlate zones and to assist with structure and isopach mapping, logs help define physical rock characteristics such as lithology, porosity, pore geometry, and permeability. Logging data is used to identify productive zones, to determine depth and thickness of zones, to distinguish between oil, gas, or water in a reservoir, and to estimate hydrocarbon reserves. Also, geologic maps developed from log interpretation help with determining facies relationships and drilling locations.As logging tools and interpretive methods are developing in accuracy and sophistication, they are playing an expanded role in the geological decision-making process. Today, petrophysical log interpretation is one of the most useful and important tools available to a petroleum geologist.Besides their traditional use in exploration to correlate zones and to assist with structure and isopach mapping, logs help define physical rock characteristics such as lithology, porosity, pore geometry, and permeability, Logging data is used to identify productive zones, to determine depth and thickness of zones, to distinguish between oil, gas, or water in a reservoir, and to estimate hydrocarbon reserves. Also, geologic maps developed from log interpretation help with determining facies relationships and drilling locations. Of the various types of logs, the ones used most frequently in hydrocarbon exploration are called
Barnacle culture: background, potential and challenges (2010)

There are approximately a dozen species of commercially interesting barnacles worldwide, some of which have been cultured on a semi-industrial scale. These species are listed and information is provided with regard to geographical distribution, landings and prices. Traditionally, ‘goose’ barnacles (four species) are considered to be the most important for consumption. World production already stands at 500 tonnes year−1, but this species has not been cultured to date. Some ‘acorn’ barnacles are also consumed (seven species), with harvest levels per species that do not exceed 200 tonnes year−1 and selling prices that can reach US$17/kg. ‘Acorn’ barnacle culture on a world scale is still developing. Nevertheless, production has occurred on a semi-industrial scale; specifically, spat have been collected from the wild and grown in suspended systems. Farming trials have focused on two species of acorn barnacles: Austromegabalanus psittacus (Molina 1782) ‘picoroco’ in Chile and Megabalanus azoricus (Pilsbry 1916) ‘craca’ in Portugal. The large-scale production of these crustaceans will depend on the optimization of spat collection from the wild and/or the parallel development of mass production technologies for larvae (hatcheries). In addition, further development will be achieved by opening up new markets for commercialization.
CSF tau proteins in differential diagnosis of dementia (2010)

Abstract Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) represent an important differential diagnostic problem in clinical practice. The identification for new biomarkers that would help establishing the diagnosis and primary cause of the dementia is therefore highly relevant. The aim of this study was to investigate the diagnostic accuracy of three potential CSF biomarkers, total tau protein (t-tau), tau protein phosphorylated at threonine 181 (p-tau181), and tau protein phosphorylated at serine 199 (p-tau199) in the differential diagnosis of AD and FTLD patients in relatively young age groups. The concentrations of the three CSF biomarkers were measured in 25 FTLD patients, 27 AD patients, and 25 non-demented (ND) subjects. The CSF concentrations of all three markers were significantly higher in AD than in FTLD cases (p < 0.001) or ND controls (p < 0.001). No difference was observed in FTLD compared to the ND group, except for p-tau181 (p = 0.028). When sensitivity was set at 85% or higher, specificity in differentiation between FTLD and AD patients reached 40% for t-tau, 37.5% for p-tau181 and 56% for p-tau199. Improvement of the diagnostic accuracy upon logistic regression analysis with t-tau and p-tau199 as independent variables showed that 22 out of 25 FTLD patients could be correctly classified. In conclusion, none of the markers per se fulfilled the criteria for the „ideal“ marker (sensitivity and specificity higher than 85%). However, combination of t-tau and p-tau199 classified correctly 88% of FTLD patients, thus largely satisfying practical requirements.
Spontaneous regression of human melanoma/nonmelanoma skin cancer: Association with infiltrating CD4<sup>+</sup> T cells (1995)

Spontaneous regression occurs in some human malignant melanomas and basal cell carcinomas (BCCs). We have compared the cellular infiltrate in regressing and nonregressing tumors in order to analyze the mechanism by which regression occurs. Regressing primary melanomas and BCCs were infiltrated with a larger number of CD4+, but not CD8+, T lymphocytes than were seen in nonregressing tumors. The number of interleukin 2 receptor-positive (early activation marker) but not transferrin receptor-positive (intermediate activation marker) T cells was increased, indicating that the infiltrating T cells were activated. Large numbers of Langerhans cells, macrophages, and other class II major histocompatibility complex (MHC)-expressing cells were present but were not increased in the regressing tumors. There were no detectable B lymphocytes, and the regressing tumor cells displayed levels of HLA-DR expression similar to those of the nonregressing tumors. Comparison of squamous cell carcinoma (SCCs) with keratoacanthomas (KAs), which are likely to be a spontaneously regressing form of SCC, also showed increased infiltration of activated CD4+, but not CD8+, T cells within the KA. A murine ultraviolet (UV)-induced squamous tumor that spontaneously regresses when transplanted into immunocompetent syngeneic mice was also infiltrated with increased numbers of activated CD4+, but not CD8+, T cells prior to and during rejection. These results indicate that spontaneous regression of human skin tumors is likely to be immunologically mediated, and that CD4+ T lymphocytes seem to mediate this regression.
Membrane-based technologies for biogas separations (2009)

Over the past two decades, membrane processes have gained a lot of attention for the separation of gases. They have been found to be very suitable for wide scale applications owing to their reasonable cost, good selectivity and easily engineered modules. This critical review primarily focuses on the various aspects of membrane processes related to the separation of biogas, more in specific CO2 and H2S removal from CH4 and H2 streams. Considering the limitations of inorganic materials for membranes, the present review will only focus on work done with polymeric materials. An overview on the performance of commercial membranes and lab-made membranes highlighting the problems associated with their applications will be given first. The development studies carried out to enhance the performance of membranes for gas separation will be discussed in the subsequent section. This review has been broadly divided into three sections (i) performance of commercial polymeric membranes (ii) performance of lab-made polymeric membranes and (iii) performance of mixed matrix membranes (MMMs) for gas separations. It will include structural modifications at polymer level, polymer blending, as well as synthesis of mixed matrix membranes, for which addition of silane-coupling agents and selection of suitable fillers will receive special attention. Apart from an overview of the different membrane materials, the study will also highlight the effects of different operating conditions that eventually decide the performance and longevity of membrane applications in gas separations. The discussion will be largely restricted to the studies carried out on polyimide (PI), cellulose acetate (CA), polysulfone (PSf) and polydimethyl siloxane (PDMS) membranes, as these membrane materials have been most widely used for commercial applications. Finally, the most important strategies that would ensure new commercial applications will be discussed (156 references).
A MORTISED TRANSFACET BONE BLOCK FOR LUMBOSACRAL FUSION (1949)

Lumbosacral fusion must be considered in light of the newer concepts developed through surgical treatment of herniated intervertebral discs. Structural faults must be re-evaluated. Stabilization by fusion is still the treatment of choice in lumbosacral instability, irrespective of the spectacular results obtained after removal of the disc without fusion. Pseudarthrosis, especially of the fourth and fifth lumbar segments, has been found frequently after the regular types of fusion, and a special technique is necessary. The technique described for accurately impacting a mortised transfacet bone block under interlaminal distraction has the following advantages: 1. The period of confinement in bed is increased very little over that required for simple removal of a herniateti disc. 2. The fusion technique adds thirty minutes or less to the time involved in removing a herniated disc. 3. There is a minimum amount of mutilation of the spinal structures. 4. The articular facets are fused, which is of mechanical advantage. 5. The bone block rigidly stabilizes interlaminal motion, immediately after being countersunk into position. 6. Extension of the spine after operation locks the bone grafts firmly into position.