gebhart/patrepeval huggingface dataset:
Supplementing Cognitive Aging: A Selective Review of the Effects of Ginkgo Biloba and a Number of Everyday Nutritional Substances (2009)

This review concerns a number of substances that have been receiving much attention, particularly in the media, for their potential to protect against age-related cognitive decline, and a focus is placed upon recent findings. Omega-3 fatty acids appear to play important roles in preserving neuronal structure and function and minimizing cognitive decline, whereas the antioxidant vitamins C and E appear to be particularly beneficial for combating age-related oxidative stress when administered in combination. Fruit and vegetable polyphenols also offer great potential, although most research thus far has involved rodents. Finally, there is mixed evidence regarding the cognitive enhancing properties of Ginkgo biloba, and the B vitamins folate and cobalamin, with all of these requiring further investigation.
Intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: a prospective randomized double-blind sham-controlled multi-center study (2018)

Patients treated with RF ablation of the BVN for CLBP exhibited significantly greater improvement in ODI at 3 months and a higher responder rate than sham treated controls. BVN ablation represents a potential minimally invasive treatment for the relief of chronic low back pain. These slides can be retrieved under Electronic Supplementary Material.
The physics of fingerprints and their detection (1978)

The mechanics of the formation of fingerprints is discussed as well as results of microscopic observations that have led to an understanding of the interaction of fingerprints with flat surfaces. Measurements of contact angles, optical properties and electrical properties of fingerprints are also described. Work on the mechanics of powder adhesion to fingerprints is reported along with two electrostatic methods of fingerprint development. Fingerprints can be developed in vacuo by metal evaporation. Research on the mechanism of this method is discussed.
Multivariate State Estimation Technique for Remaining Useful Life Prediction of Electronic Products. (2007)

This paper investigates the use of Multivariate State Estimation Techniques as input in predicting the remaining useful life prediction of electronic products. A prognostics approach combining the Multivariate State Estimation Technique with life cycle damage prediction is then presented, along with a case study. The challenges of the approach are also discussed.
IL-7 receptor α blockade, an off-switch for autoreactive T cells (2012)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Combined Hormonal Contraceptives: Is It Time to Reassess Their Role in Migraine? (2012)

The risk/benefit analysis of CHCs is shifting. There is growing evidence for a potential role for CHCs in the prevention of menstrual-related migraine. At the same time, the risk of these products is declining, as newer and lower dose formulations replace their historical predecessors. And although migraine aura is a risk factor for stroke, there is not convincing evidence to suggest that the addition of a low-dose CHC alters that risk in non-smoking, normotensive users. Selected hormonal preventives could potentially decrease stroke risk in MwA via reduction in aura frequency achieved by reducing peak estrogen exposure. With this shift in risk/benefit analysis, it is time to reconsider the role of CHCs in migraine - both with and without aura.
Non-invasive timing analysis of IBM G6 microprocessor L1 cache using picosecond imaging circuit analysis (2002)

The new non-invasive backside timing characterization technique, Picosecond Imaging Circuit Analysis (PICA), was applied to the identification and analysis of a race condition which occurred in an early design of the L1 cache of the S/390 microprocessor. The circuit switching activity was visualized in reconstructed slow motion videos of passing and failing conditions. An automated emission waveform extraction and analysis tool was used to perform a quantitative study of the failing condition.
A new technology for Si microwave power transistor manufacturing (2002)

We, for the first time, demonstrate a new process for Si power transistor manufacturing. The new process, combining the HMIC process and flip-chip process, completely changes the Si power transistor internal matching circuits design and manufacturing. S-band Si power transistor was used as a testing vehicle and under pulse operation condition. Pout=23 W with 7.9 dB of gain and 39% of efficiency were obtained at f=3.05 GHz and Vcc=36 V.
Structurally Related Spc1p and Spc2p of Yeast Signal Peptidase Complex Are Functionally Distinct (1996)

Two subunits of the mammalian signal peptidase complex, SPC12 and SPC25, share similar membrane topologies with the majority of each protein oriented toward the cytoplasm. Such similarities may suggest that these proteins perform redundant functions in signal peptidase activity. In the present study, we addressed this issue through analysis of the yeast homologs to SPC12 and SPC25, Spc1p and Spc2p. We show that both Spc1p and Spc2p are nonessential for signal peptidase activity and growth of yeast cells and that null mutations in the genes encoding Spc1p and Spc2p are synthetically lethal with a conditional mutation affecting Sec11p, an essential subunit of yeast signal peptidase. However, a high copy plasmid encoding Spc1p suppresses the conditional sec11 mutation, whereas the corresponding plasmid encoding Spc2p does not suppress sec11. Moreover, Spc2p, but not Spc1p, is important for signal peptidase activity and cell viability at high temperatures. These results indicate that although both Spc1p and Spc2p are noncatalytic, they are functionally distinct. Evidence is also presented that a double mutant lacking Spc1p and Spc2p grows well relative to wild type yeast cells, indicating that the signal peptidase complex missing at least two of its subunits is sufficient for signal peptidase activity in vivo.
A near‐infrarod spectroscopy technique for the control of fermentation processes: An application to lactic acid fermentation (1994)

A near-infrared (NIR) spectroscopy technique for the control of lactic acid fermentation process has been proposed. Lactic acid, glucose, and biomass concentrations were determined by the NIR spectroscopy method. The three parameters examined were closely correlated to the results obtained with classical laboratory procedures. Moreover, the conditions for the on-line utilization of the NIR spectroscopy measurement system were pointed out. The great versatility of the NIR spectroscopy should permit its use for other fermentation processes. (c) 1994 John Wiley & Sons, Inc.
The effect of low‐level Nd:YAG laser energy on adult articular cartilage in vitro (1992)

Reports of laser energy applied to soft tissues in vitro and in vivo suggest both stimulation and inhibition of specific metabolic processes, depending on the type of laser, the energy density (ED) used, the mode of delivery, and type of tissue studied. An earlier in vitro study of Nd:YAG laser irradiation of articular cartilage indicated stimulation of both matrix and DNA synthesis for 6 days following laser exposure. In vivo reports on the ability of Nd:YAG laser energy to stimulate the healing of partial-thickness cartilage defects are conflicting. In the present study, a noncontact continuous-wave Nd:YAG laser beam of varying EDs was applied to full-thickness adult articular cartilage explants maintained in organ culture; the metabolic processes of chondrocyte DNA synthesis and matrix synthesis were followed over 2 weeks. For both canine and bovine cartilage, low-levels of laser energy (ED 51-127 J/cm2) stimulated matrix synthesis at 6-7 days following laser exposure, with a concomitant decrease in baseline DNA synthesis. By 12-14 days, however, these dose-dependent effects were no longer seen, with no significant differences from control noted for any of the laser energies studied. Histologic analysis of the cartilage explants following laser exposure showed no significant differences in cell number or morphology between sample and control groups; however, a decrease in matrix proteoglycan staining was seen in the highest laser energy group at all time points. These findings indicate that exposure to low-level noncontact Nd:YAG laser energy promotes a significant stimulation of cartilage matrix synthesis. However, a single exposure may not be sufficient to promote a sustained upregulation of cartilage metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)
[Conditions for splitting protodioscine--the main glycoside from Tribulus terrestris L. by the enzymatic preparation from Aspergillus niger BKMt-33]. (1975)

The conditions for splitting protodioscine--the main steroid saponine isolated from Tribulus terrestris L. by the enzymic preparation of Aspergillus niger str. BKMt-33 were investigated. The optimal conditions were found to be as follows: pH 4-5, temperature 30-37 degrees (the substrate concentration--5 mg%, concentration of the enzymic preparation--1%). Under these conditions the enzymolysis continued 24 hours. Mg+2 and K+ ions accelerated the reaction twice. As a result of the enzymic hydrolysis dioscine and trilline were obtained. This indicates beta-glucosidase and alpha-rhamnosidase activities of the enzymic complex isolated from Aspergillus niger str. BKMt-33.
Microsoft SQL Server 2000オフィシャルマニュアル (2001)

第４部 組み込みのサーバー機能（コンポーネントサービスとＭＳ ＤＴＣ；ＳＱＬ Ｓｅｒｖｅｒにおけるレプリケーションの概要とスナップショットレプリケーション；トランザクションレプリケーション；マージレプリケーション；Ａｎａｌｙｓｅｓ Ｓｅｒｖｉｃｅｓ） 第５部 管理、チューニング、保守、およびトラブルシューティング（ＳＱＬ Ｓｅｒｖｅｒの管理；管理作業の自動化；ＳＱＬ Ｓｅｒｖｅｒのバックアップ；データベースの復元と復旧；ユーザとセキュリティの管理；ＳＱＬクエリアナライザとＳＱＬプロファイラの使用；一般的なパフォーマンスの問題の解決） 第６部 付録（ＳＱＬ Ｓｅｒｖｅｒの設定オプション；ＳＱＬ Ｓｅｒｖｅｒの監視；ＤＢＣＣコマンド）
Polymorphism by name for references and continuations (1993)

This article investigates an ML-like language with byname semantics for polymorphism: polymorphic objects are not evaluated once for all at generalization time, but re-evaluated at each specialization. Unlike the standard ML semantics, the by-name semantics works well with polymorphic references and polymorphic continuations: the naive typing rules for references and for continuations are sound with respect to this semantics. Polymorphism by name leads to a better integration of these imperative features into the ML type discipline. Practical experience shows that it retains most of the efficiency and predictability of polymorphism by value.
Parasite Genomics Protocols (2004)

Parasitic disease remains an important health issue in most regions of the world and constitutes a major cause of morbidity and mortality in developing countries. In Parasite Genomics Protocols, pioneering bench researchers describe in detail the cutting-edge techniques they have developed for analyzing the genomes and gene products in a diverse range of protozoan and metazoan parasites. These readily reproducible techniques can be used in genomic, functional genomic, and postgenomic studies and include transfection methods and vectors for several protozoan parasites, global analysis using microarrays, gene ablation using RNA interference, gene knockout, mutagenesis, and chromosome manipulation. Some of the protocols require DNA sequence data, whereas others were developed independently of whole-genome sequence data. Additional chapters survey the available genome sequences, helping novice researchers overcome the difficulties of accessing the databases and applying bioinformatics analysis to biological function. The protocols presented follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and the avoidance of known pitfalls. State-of-the-art and highly practical, Parasite Genomics Protocols offers bench investigators in parasitology a wide-ranging collection of diverse methods for elucidating the content of the genomes of parasitic organisms, utilizing the genome sequence for genetic analysis, and ascribing function to the available genome sequences
Statistical multilocus methods for disequilibrium analysis in complex traits (2001)

Hundreds of thousands of SNP markers are being generated with the purpose of carrying out case-control association studies for complex traits, which are thought to be due to multiple underlying susceptibility genes. The number of markers is typically much larger than the number of observations so that joint analysis of marker genotypes and their interactions is not feasible. We discuss a two-stage approach to first select a small subset of markers and then model the effects of the selected markers on disease. Examples of two procedures for marker selection are given with subsequent modeling of main and interaction effects. The approaches are applied to a data set with 89 SNPs in lieu of a genome screen with many more markers.
Successful Fluorescence-Guided Surgery on Human Colon Cancer Patient-Derived Orthotopic Xenograft Mouse Models Using a Fluorophore-Conjugated Anti-CEA Antibody and a Portable Imaging System (2014)

The results of the present report indicate that FGS using a fluorophore-conjugated anti-CEA antibody and portable imaging system improves efficacy of resection for CEA-positive colorectal cancer. These data provide the basis for clinical trials.
Smooth muscle calponin (1989)

Conference Article| August 01 1989 Smooth muscle calponin STEVEN J. WINDER; STEVEN J. WINDER 1Department of Medical Biochemistry, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, T2N 4N1 Canada Search for other works by this author on: This Site PubMed Google Scholar MICHAEL P. WALSH MICHAEL P. WALSH 1Department of Medical Biochemistry, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, T2N 4N1 Canada Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (4): 786–787. https://doi.org/10.1042/bst0170786 Article history Received: November 23 1988 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation STEVEN J. WINDER, MICHAEL P. WALSH; Smooth muscle calponin. Biochem Soc Trans 1 August 1989; 17 (4): 786–787. doi: https://doi.org/10.1042/bst0170786 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Peptide transporters and antigen processing. (1994)

Our knowledge about intracellular pathways involved in the presentation of antigens was considerably broadened with the recent discovery of peptide transporters encoded in the major histocompatibility complex. The transporter associated with antigen processing (TAP) belongs to an evolutionary conserved family of multimembrane-spanning translocators that bind ATP and show specificity for a variety of different substrates. TAP mediates the translocation of peptides, generated by cytosolic degradation of protein antigens, into the lumen of the endoplasmic reticulum where they bind to newly synthesized MHC class I molecules. A novel assay has been employed to elucidate the details of TAP-mediated peptide transport. The results indicate that TAP selects peptides of sequence and length according to the requirements of MHC class I molecules in different species.
Stereoselective Organic Reactions: Catalysts for Carbonyl Addition Processes (1988)

Important advances are being made in the development of stereoselective organic reactions. Some of the emerging research directions that hold forth great promise in this area deal with the development of chiral catalysts for these processes. This review attempts to unify one aspect of this field, the development of catalysts and catalyst models for the enantioselective addition of hydride and carbon nucleophiles to carbonyl substrates. Mechanistic constructs for the stereodifferentiating transition states are provided.
Five years of progress in the Standardization of Proteomics Data 4<sup>th</sup> Annual Spring Workshop of the HUPO‐Proteomics Standards Initiative April 23–25, 2007 Ecole Nationale Supérieure (ENS), Lyon, France (2007)

Over the last five years, the Human Proteome Organisation Proteomics Standards Initiative (HUPO PSI) has produced and released community-accepted XML interchange formats in the fields of mass spectrometry, molecular interactions and gel electrophoresis, have led the field in the discussion of the minimum information with which such data should be annotated and are now in the process of publishing much of this information. At this 4(th) Spring workshop, the emphasis was on consolidating this effort, refining and improving the existing models and in pushing these forward to align with more broadly encompassing efforts such as FuGE (Jones, A.R., Pizarro, A., Spellman, P., Miller, M., FuGE Working Group FuGE: Functional Genomics Experiment Object Model. OMICS 2006, 10, 179-184) and the Ontology for Biomedical Investigation (OBI). The effort to merge the existing mass spectrometry XML interchange formats, mzData and mzXML, into one single standard mzML yielded significant progress. Also the preliminary design of AnalysisXML was extended to include several new use cases and better support for quantification information. Finally the Molecular Interaction group discussed the development of a molecular interaction scoring system with accompanying gold standard data test sets.
Indicator dilution using a fluorescent indicator (1982)

In vitro and in vivo indicator-dilution measurements are made with a fluorescent indicator and a novel detection system using a catheter containing a single optical fiber that carries both the exciting and returning fluorescent light. These fluorescent-dilution measurements are compared with simultaneous green dye-dilution measurements. The double-indicator-dilution measurement of extravascular lung water using heat and fluorescence is compared with gravimetric measurements. Also investigated is the sensitivity of the fluorescent measurement to changes in O2 saturation and hematocrit of the blood. An example of the measurement of a right-to-left heart shunt with this new indicator is given.
Plant Growth Regulators for Avocado Production (2006)

Background Plant growth regulators (PGRs) are the most powerful tools for manipulating tree growth and yield in an existing orchard. A quick review of current commercial uses of PGRs in apple, citrus, stone fruit, nut, kiwi, and grape production provides insight into the physiological processes that can be influenced to the economic benefit of growers. PGRs are used successfully to manipulate flowering. Benzyladenine (6benzylaminopurine, BA) causes early bud break in numerous tree crops and increases floral bud retention of pistachio (Lovatt and Ferguson, 1999). Gibberellic acid (GA3) inhibits or delays flowering in deciduous tree crops (Sedgley, 1990) and citrus if applied before irreversible commitment to flowering (Lord and Eckard, 1987). After this developmental stage, GA3 is without effect on many crops including coffee (Schuch et al., 1990) and mango (Kachru et al., 1972). PGRs are used to manipulate fruiting. The powerful synthetic diphenylurea-type cytokinin 1-(2-chloro-4-pyridynl)-3 -phenylurea (forchlorfenuron, CPPU), the synthetic auxin 2,4-dichlorooxyacetic acid (2,4-D) and GA3 all have the capacity to stimulate parthenocarpic fruit development in various crops. GA3, BA, CPPU, 2,4-D and the powerful synthetic auxin 3,5,6-trichloropyridyloxyacetic acid (3,5,6-TPA) stimulate fruit growth directly to increase fruit size, but with the caveat that a PGR may be more effective on some crops than on others. GA3, 2,4-D and aminoethoxyvinylglycine (AVG) reduce early drop, which occurs during the initial fruit set period, June drop and preharvest drop of mature fruit. In contrast, ethylene-releasing compounds, such as 2chloroethyl phosphonic acid (ethephon, CEPA), the auxin naphthalene acetic acid (NAA), and even BA at high concentration are used to induce flower or fruit abscission to reduce fruit number and indirectly increase fruit size. PGRs are used to manipulate fruit quality both in the orchard and in the packinghouse. Ethephon can be used preharvest to advance color development and fruit maturation (ripening), whereas GA3 delays color development and maturity in tree crops, including citrus. Ethephon is also used to loosen fruit to increase the efficiency of mechanical or hand harvesting of nut crops, olives, cherries, plums and citrus (Jaumien and Rejman, 1978; Knapp, 1981; Metzidakis, 1999). The PGRs abscisic acid (ABA), 2,3,5triiodobenzoic acid (TIBA) and methyl jasmonate have also been shown to increase fruit loosening in citrus (Burns et al., 2003; Kender et al., 2001; Hartmond et al., 2000). Ethylene-releasing compounds are also used postharvest to enhance color development and ripening.
Photooxidation with Rose Bengal of a Critical Histidine Residue in Yeast Enolase<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotooxidation with Rose Bengal of a Critical Histidine Residue in Yeast Enolase*Edward W. WestheadCite this: Biochemistry 1965, 4, 10, 2139–2144Publication Date (Print):October 1, 1965Publication History Published online1 May 2002Published inissue 1 October 1965https://pubs.acs.org/doi/10.1021/bi00886a031https://doi.org/10.1021/bi00886a031research-articleACS PublicationsRequest reuse permissionsArticle Views242Altmetric-Citations164LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells (2012)

Overexpression of IL-8 promotes the adhesion, migration, invasion, and chemoresistance of GC cells, indicating that IL-8 is an important therapeutic target in GC.
Studies on peptides. CXXX. Convenient procedure for the reduction of methionine sulfoxide. (1985)

Selenophenol was found to be an effective reducing reagent for Met (O) in protected peptides. Trimethylphenylthiosilane and its combination with tetrabutylammonium bromide were also found to have a powerful ability to reduce Met (O).