gebhart/patrepeval huggingface dataset:
SIM 1.0, BIBLIOTECA DE ALGORITMOS EN R PARA EL APOYO A LA ASIGNATURA DE SIMULACIÓN. (2019)

En la Universidad de las Ciencias Informaticas se incluye en el 4to ano de la carrera la asignatura de Simulacion. La misma centra su objetivo en aplicar la simulacion en el planteamiento y solucion de problemas de direccion para el apoyo a la  toma de decisiones. La practica en la ensenanza de la asignatura se apoya en materiales que realizan los profesores. Sin embargo no se cuenta con un compendio de los algoritmos relevantes y usados en la asignatura  segun su programa analitico. La presente investigacion describe una solucion a la problematica planteada a partir de la implementacion de una biblioteca de caracter didactica, utilizando el software R, que contenga la totalidad de los algoritmos utilizados en la asignatura,  asi como una salida que describa los aspectos de interes de cada uno de ellos. Sim pone a disposicion algoritmos para la generacion de numeros aleatorios, de observaciones aleatorias con distribucion no uniforme, metodos estadisticos para la validacion de aleatoriedad y uniformidad, asi como tecnicas de reduccion de varianza en un conjunto de numeros aleatorios generados.
<i>Mycobacterium tuberculosis</i> Keto-Mycolic Acid and Macrophage Nuclear Receptor TR4 Modulate Foamy Biogenesis in Granulomas: A Case of a Heterologous and Noncanonical Ligand-Receptor Pair (2014)

The cell wall of Mycobacterium tuberculosis is configured of bioactive lipid classes that are essential for virulence and potentially involved in the formation of foamy macrophages (FMs) and granulomas. Our recent work established crosstalk between M. tuberculosis cell wall lipids and the host lipid-sensing nuclear receptor TR4. In this study, we have characterized, identified, and adopted a heterologous ligand keto-mycolic acid from among M. tuberculosis lipid repertoire for the host orphan NR TR4. Crosstalk between cell wall lipids and TR4 was analyzed by transactivation and promoter reporter assays. Mycolic acid (MA) was found to transactivate TR4 significantly compared with other cell wall lipids. Among the MA, the oxygenated form, keto-MA, was responsible for transactivation, and the identity was validated by TR4 binding assays followed by TLC and nuclear magnetic resonance. Isothermal titration calorimetry revealed that keto-MA binding to TR4 is energetically favorable. This keto-MA-TR4 axis seems to be essential to this oxygenated MA induction of FMs and granuloma formation as evaluated by in vitro and in vivo model of granuloma formation. TR4 binding with keto-MA features a unique association of host nuclear receptor with a bacterial lipid and adds to the presently known ligand repertoire beyond dietary lipids. Pharmacologic modulation of this heterologous axis may hold promise as an adjunct therapy to frontline tuberculosis drugs.
Data quality and data cleaning (2003)

Data quality is a serious concern in any data-driven enterprise, often creating misleading findings during data mining, and causing process disruptions in operational databases. The manifestations of data quality problems can be very expensive- "losing" customers, "misplacing" billions of dollars worth of equipment, misallocated resources due to glitched forecasts, and so on. Solving data quality problems typically requires a very large investment of time and energy -- often 80% to 90% of a data analysis project is spent in making the data reliable enough that the results can be trusted.In this tutorial, we present a multi disciplinary approach to data quality problems. We start by discussing the meaning of data quality and the sources of data quality problems. We show how these problems can be addressed by a multidisciplinary approach, combining techniques from management science, statistics, database research, and metadata management. Next, we present an updated definition of data quality metrics, and illustrate their application with a case study. We conclude with a survey of recent database research that is relevant to data quality problems, and suggest directions for future research.
Gender Differences in Strength and Lower Extremity Kinematics During Landing (2002)

This study evaluated kinematic, vertical ground reaction forces, and strength variables in healthy collegiate female basketball, volleyball, and soccer players compared with matched male subjects. Thirty athletes did single-leg landing and forward hop tasks. An electromagnetic tracking device synchronized with a force plate provided kinematic data and vertical ground reaction force data, respectively. Maximum angular displacement and time to maximum angular displacement kinematic variables were calculated for hip flexion, abduction, rotation, knee flexion, and lower leg rotation. Vertical ground reaction force data normalized to body mass provided impulse, maximum force, time to maximum force, and stabilization time variables. An isokinetic device measured quadriceps and hamstring peak torque to body mass at 60 degrees /second. With both tasks, females had significantly less knee flexion and lower leg internal rotation maximum angular displacement, and less knee flexion time to maximum angular displacement than males. For the single-leg land, females had significantly more hip internal rotation maximum angular displacement, and less lower leg internal rotation time to maximum angular displacement than males. For the forward hop, females had significantly more hip rotation time to maximum angular displacement than males. Females also had significantly less peak torque to body mass for the quadriceps and hamstrings than males. Weaker thigh musculature may be related to the abrupt stiffening of the knee and lower leg on landing in females.
Vivant et féminin dans le parcours phobique (2005)

Le quartier de la Goutte-d’Or, situe dans le nord de Paris, est marque par une forte presence de migrants originaires d’Afrique subsaharienne. En l’espace de vingt ans, des entrepreneurs senegalais ont developpe au cœur de ce carrefour migratoire un maillage serre de petits commerces. Loin d’etre circonscrit a l’echelle du quartier, leur dynamisme economique s’inscrit dans une strategie plus vaste. Derriere les vitrines de ces magasins se distinguent les relais d'un veritable commerce transnational qui deploie ses reseaux de Dakar vers le reste du monde.
Control of a PTZ Camera in a Hybrid Vision System (2014)

Abstract: In this paper, we propose a new approach to steer a PTZ camera in the direction of a detected object visible from another fixed camera equipped with a fisheye lens. This heterogeneous association of two cameras having different characteristics is called a hybrid stereo-vision system. The presented method employs epipolar geometry in a smart way in order to reduce the range of search of the desired region of interest. Furthermore, we proposed a target recognition method designed to cope with the illumination problems, the distortion of the omnidirectional image and the inherent dissimilarity of resolution and color responses between both cameras. Experimental results with synthetic and real images show the robustness of the proposed method. 1
A Novel Interaction of the Golgi Complex with the Vimentin Intermediate Filament Cytoskeleton (2001)

The integration of the vimentin intermediate filament (IF) cytoskeleton and cellular organelles in vivo is an incompletely understood process, and the identities of proteins participating in such events are largely unknown. Here, we show that the Golgi complex interacts with the vimentin IF cytoskeleton, and that the Golgi protein formiminotransferase cyclodeaminase (FTCD) participates in this interaction. We show that the peripherally associated Golgi protein FTCD binds directly to vimentin subunits and to polymerized vimentin filaments in vivo and in vitro. Expression of FTCD in cultured cells results in the formation of extensive FTCD-containing fibers originating from the Golgi region, and is paralleled by a dramatic rearrangements of the vimentin IF cytoskeleton in a coordinate process in which vimentin filaments and FTCD integrate into chimeric fibers. Formation of the FTCD fibers is obligatorily coupled to vimentin assembly and does not occur in vim(-/-) cells. The FTCD-mediated regulation of vimentin IF is not a secondary effect of changes in the microtubule or the actin cytoskeletons, since those cytoskeletal systems appear unaffected by FTCD expression. The assembly of the FTCD/vimentin fibers causes a coordinate change in the structure of the Golgi complex and results in Golgi fragmentation into individual elements that are tethered to the FTCD/vimentin fibers. The observed interaction of Golgi elements with vimentin filaments and the ability of FTCD to specifically interacts with both Golgi membrane and vimentin filaments and promote their association suggest that FTCD might be a candidate protein integrating the Golgi compartment with the IF cytoskeleton.
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] (1998)

Respiratory papillomatosis is a rare and often severe disease, usually localized in the larynx. It may cause respiratory distress and even life-threatening obstruction of the airways. Treatment is generally based on the evaporation of the lesions with a CO2 laser, but microsurgery, cytotoxic and/or cytostatic drugs, interferons, and vaccines are also used. Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine] (HPMPC) was shown to suppress the growth of tumors induced by rabbit papillomavirus as well as human papillomavirus (HPV). The efficacy of cidofovir was assessed in 17 patients with severe respiratory papillomatosis. Cidofovir at a concentration of 2.5 mg/ml was injected directly in the different laryngeal papillomatous lesions during microlaryngoscopy under general anesthesia. Biopsies were taken before the treatment was started both for anatomopathology and viral typing. HPMPC kinetics in serum was monitored in three patients, the drug levels being determined by high-performance liquid chromatography. Complete disappearance of the papillomatosis was observed in 14 patients. Four patients relapsed and were successfully treated again with cidofovir. Of the three remaining patients, one progressed while under treatment with cidofovir, after an initial marked response. One patient had a partial remission and remained stable for more than 1 year after the last injection. He had a very aggressive and extensive disease originally. Finally, one patient was lost to follow-up after four injections. Intratumoral injections of cidofovir for the treatment of severe laryngeal papillomatosis is a powerful new therapeutic approach for this disease. Treatment was well tolerated, and no significant side effects were noted.
Functional 3D photonic films from polymer beads (2007)

Abstract This paper describes synthesis and properties of polymer opals with a special emphasis on functional opals. Polymer opals are formed from monodisperse polymer colloids by self‐assembly. Their potential applications range from coloring pigments, 3D bicontinuous supports for catalysis to photonic materials. This latter application requires especially the controlled creation of defects and the incorporation of fluorescent materials. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Work in progress - development of tools to improve the spatial ability of engineering students (2005)

One component of spatial ability is the ability to correctly visualize a three dimensional object when it is represented in two dimensional space. Research has shown that spatial ability is positively correlated with retention and performance of students in disciplines which rely heavily on spatial reasoning (e.g. chemistry, engineering, etc.) and that males typically outperform females on standard spatial ability tests. In addition, research has shown that spatial ability can be improved through training, such as that received in a computer aided design (CAD) course or by focused spatial training. However, which type of training provides the most beneficial improvements to spatial ability is not well known and whether other means to improve spatial ability would be more effective. In this research project, two tools to use in spatial ability training are being developed. One tool, a physical model rotator (PMR), rotates a physical model of an object in synchronous motion with a model of the same object in CAD software. The other training tool, the alternative view screen (AVS), provides the user of CAD software with both a solid model (including shading) and a line version view of the object. Students with poor spatial ability were identified through testing and the effects of training with these two tools were assessed
Photo2ClipArt: Image Abstraction and Vectorization Using Layered Linear Gradients (2017)

International audience
Microchip technology in mass spectrometry-based bioanalysis: Advances in the analysis of peptides, proteins, and pharmaceuticals (2015)

Analytical microsystems are attractive in modern bioanalysis where sample amounts often are low and fast analyses are required. Microsystems also provide the prospect of integrating several functional elements on a single platform. The aim of this work was to develop analytical microsystems for fast analysis of bio- and drug molecules. For this, microchips with separation- and injection channels and monolithically integrated electrospray ionization (ESI) emitter were fabricated of epoxy photoresist SU-8 by photolithography and adhesive bonding. \n\nFor peptide mass fingerprinting and protein sequencing characteristic tryptic peptides were fast and easily separated and detected by microchip capillary electrophoresis (MCE)-ESI/mass spectrometry (MS). Additionally, protein identification based on tandem MS fragmentation data of a single tryptic peptide was achieved. Finally, this rapid (total analysis time below ten minutes) microchip method permitted analysis of human muscle cell lysates. \n\nFor online coupling of microchip capillary isoelectric focusing (cIEF) to ESI/MS a bilateral sheath flow interface or a two-dimensional separation unit was integrated on-chip. Rapid focusing of peptides by their isoelectric points (pI) was achieved without pretreatment of the SU-8 surface. After focusing the peptides were electrokinetically mobilized toward ESI/MS. The two-dimensional chip design enabled unique separation selectivity for peptides based on both pI values and intrinsic electrophoretic mobilities by multiplex-cIEF-transient-isotachophoresis. \n\nRapid metabolic profiling was demonstrated from urine after intake of tramadol or paracetamol. Both phase I- and II metabolites were separated and detected by MCE-ESI/MS within 35 s. In addition, Michaelis-Menten kinetics was successfully determined for the CYP450-mediated oxidation of bufuralol to 1-hydroxybufuralol. \n\nSample preconcentration (pretreatment) was integrated on-chip by solid-phase extraction (SPE) and liquid-phase microextraction (LPME). For SPE, a monolith zone was firmly anchored at the injection cross of the MCE-ESI/MS microchip by laser induced photopolymerization. The monolith was selective toward hydrophobic and hydrophilic sample molecules and enrichment factors as high as 23-fold was achieved with a loading time as short as 25 s. In addition, LPME was easily downscaled to low volume applications and offered selectivity in the analysis of phase I metabolites compared to SPE. \n\nIn contrast to previous research in the same field this work offers bioanalysis with several on-chip integrated steps (preconcentration, injection, separation, and analysis) without considerably increasing the short analysis times characteristic of microchip assays.
An area-scalable two-layer evaporator wick concept for high-heat-flux vapor chambers (2017)

For vapor chamber heat spreaders to operate at very high heat fluxes, the internal wick layer at the evaporator must simultaneously minimize the device temperature rise and the flow resistance to liquid resupply by capillary action. Prior investigations in the literature have reported sustained capillary-fed boiling at heat fluxes as high as 1 kW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for small hotspots of significantly less than ~1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . However, the need to provide liquid feeding to avoid dryout prevents high levels of heat fluxes from being dissipated over areas any larger than localized hotspots. Thin layers of homogeneous evaporator wicks can help reduce the thermal resistance across the layer, but fail to sustain adequate liquid supply at high heat fluxes or over large areas. Thicker evaporator wicks offer greater flow cross-sections to better feed liquid to the evaporator by capillary action, but induce unacceptably large surface superheats due to the high thermal resistance across these thick layers. This work proposes and analyzes a hybrid two-layer evaporator wick for passive, high-heat-flux dissipation. A thick cap layer of wick material evenly routes liquid to a thin, low-thermal-resistance base layer through an array of vertical liquid-feeding posts. This two-layer structure decouples the functions of liquid resupply (cap layer) and capillary-fed boiling heat transfer (base layer), making the design scalable to heat input areas of ~1 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> for operation at 1 kW/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . A model is developed to demonstrate the potential performance of a vapor chamber incorporating such a two-layer evaporator wick design and to establish the target sizes of critical wick features that must be fabricated. The model comprises simplified hydraulic and thermal resistance networks for predicting the capillary-limited maximum heat flux and the overall thermal resistance, respectively. The performance of the vapor chamber is analyzed with varying two-layer wick geometric feature sizes.
Metal-on-Metal Hybrid Surface Arthroplasty: Two to Six-Year Follow-up Study (2004)

Therapeutic study, Level IV (case series [no, or historical, control group]). See Instructions to Authors for a complete description of levels of evidence.
Toward Rapid, “Green”, Predictable Microwave-Assisted Synthesis (2005)

Continuous and batch microwave reactors were constructed for efficient, "green" synthesis with low-boiling solvents at high temperature in closed vessels. Capabilities for rapid heating and cooling, concurrent heating and cooling, and differential heating facilitated novel chemical reactions and processes. Commercial microwave systems based on these developments are available. Times required for conventional reactions typically are decreased by 2-3 orders of magnitude. Green processes also have resulted through use of less or no catalyst, readily recyclable solvents, or media and yields that are often higher than normal. Complementary interactive software for calculating optimal conditions was developed.
Total syntheses of the meta,meta-bridged biphenyls (±)-myricanol and myricanone, and of an isomeric biphenyl ether, a 14-oxa[7,1]metaparacyclophane (1980)

The oxidative coupling of 1,7-bis(hydroxyphenyl)heptanoids (2a,b) has been investigated: C–C coupling to meta,meta-bridged biaryls was not observed, but with thallium tris(trifluoroacetate) C–O coupling occurred forming a 14-oxa[7,1]metaparacyclophane analogous to the natural phenols acerogenin-A and galeon. Intramolecular reductive coupling, using tetrakis(triphenylphosphine)nickel(0), of the bis-iodides (11a,b) derived from phenols (2a,b), leads, after deprotection, to the desired meta,meta-bridged biphenyls myricanone and (±)-myricanol, albeit in rather low yield. OO-Dimethylmyricanone and (±)-OO-dimethylmyricanol were similarly synthesized. Irradiation (254 nm) in alkaline ethanol of the bromides (11g,h) also induced aryl–aryl coupling to form dibenzylmyricanone and (±)-dibenzylmyricanol acetate respectively.
Nuclear factor  B as a target for new drug development in myeloid malignancies (2007)

The transcription nuclear factor k B (NF-kB) can intervene in oncogenesis through to its capacity to regulate the expression of a large number of genes that regulate apoptosis, cell proliferation and differentiation as well as inflammation, angiogenesis and tumor migration. Impaired NF-kB activity has been demonstrated not only in solid cancers but also in various types of hematologic malignancies including acute myeloid leukemia, chronic myelogenous leukemia and in a subset of myelodysplastic syndromes. The underlying mechanisms, illustrated in the text and although quite diverse in different diseases, provide the rationale for new therapeutic strategies combining different NF-kB or proteasome inhibitors. It has, therefore, been proposed that inhibition of NF-kB could be an adjuvant therapy for cancer and many phase I/II clinical studies are ongoing with different inhibitors. This review highlights the in vitro and in vivo results of NF-kB inhibition in myeloid malignancies.
Wireless resonant frequency detection of SiCN ceramic resonator for sensor applications (2011)

A wireless passive sensing approach is proposed to measure the resonant frequency of a dielectrically-loaded cavity resonator. This resonator is made of SiCN ceramic material which is very stable inside harsh environments with temperatures up to 1500°C. The resonator is coupled to CPW lines with one antenna placed at each end of the CPW lines. A wide-band signal is transmitted through two antenna pairs and passes the resonator with the maximum transfer of energy at the resonant frequency of the resonator, i.e. 12.6 GHz. This allows for measuring the resonant frequency of the resonator in a wireless manner. Measurement results are provided for distances up to 40 mm with good agreement with simulations. The proposed methodology is aimed for temperature/pressure sensor development inside gas turbine engines.
Correlating the clinical actions and molecular mechanisms of general anesthetics (2007)

Several clinically distinct 'anesthetic states' are induced by different classes of drugs acting on neuronal circuits via different molecular targets. Understanding the mechanisms underlying the therapeutic and toxic actions of general anesthetics helps us reframe the 'art' of anesthesia into more of a 'science'. These studies also enhance efforts to develop new drugs with improved clinical utility.
Choreographed scope manoeuvring in robotically-assisted laparoscopy with active vision guidance (2002)

This paper presents our research at bringing the state-of-the-art in vision and robotics technologies to enhance the emerging laparoscopic surgical procedure. In particular, a framework utilizing intelligent visual modeling, recognition, and serving capabilities for assisting the surgeon in manoeuvring the scope (camera) in laparoscopy is proposed. The proposed framework integrates top-down model guidance, bottom-up image analysis, and surgeon-in-the-loop monitoring for added patient safety. For the top-down directives, high-level models are used to represent the abdominal anatomy and to encode choreographed scope movement sequences based on the surgeon's knowledge. For the bottom-up analysis, vision algorithms are designed for image analysis, modeling, and matching in a flexible, deformable environment (the abdominal cavity). For reconciling the top-down and bottom-up activities, robot serving mechanisms are realized for executing choreographed scope movements with active vision guidance.