gebhart/patrepeval huggingface dataset:
Failure of alpha-methyltyrosine to prevent hypertensive crisis in pheochromocytoma (1985)

Sudden onset of a hypertensive crisis occurred shortly after induction of anesthesia in a patient with malignant pheochromocytoma, despite preoperative medical preparation with alpha-methyltyrosine (alpha-methyl-p-tyrosine) and propranolol hydrochloride. Other investigators have advocated alpha-methyltyrosine as the medical therapy of choice in the preoperative preparation of patients with pheochromocytoma. This case emphasizes the caution that should be exercised when using alpha-methyltyrosine preoperatively, without concurrent alpha-adrenergic blocking agents, to prevent intraoperative hypertensive crisis.
Specific expression of HSP47 in human tumor cell lines in vitro. (1997)

HSP47 is a stress-inducible glycoprotein of 47 kd molecular weight, and is assumed to be a collagen specific molecular chaperone. The expression of HSP47 is closely related to that of collagen, which is the main component of the extracellular matrix. We investigated the expression level of HSP47 in human tumor cell lines to elucidate collagen biosynthesis in tumor cells. Western blot analysis showed higher levels of HSP47 in solid tumor cell lines than in leukemia cell lines. Tumor cell lines which were derived from metastatic carcinomas and were still metastatic in animals, synthesized higher levels of HSP47. These results suggested that HSP47 may play an important role in tumor metastasis and can be a prognostic marker for the metastatic activity of human tumor cells.
Intracranial bleed monitor (2003)

A feasibility study to see if brain movement can be detected by ultrasound pulse Doppler is reported. The experimental setup includes a digital Doppler sampling system capable of processing 120 sample gates simultaneously (1 kHz PRF, 14 bit A/D, and 2 MHz carrier frequency with variable pulse length), and a special "headframe" (Marc 500) for holding an ultrasound probe stationary relative to the skull. Brain motions attributed to the cardiac and breathing cycle are clearly discernable with this device. Motions in which a systolic waveform are prominent span as much as 200 microns excursion distances or as little as 10-20 microns. Motions are reported with the contralateral skull as a fixed reference. These motions demonstrate the required sensitivity of an ultrasound device for detection of brain movement associated with very slow intracranial bleeding.
Calculation of Doubly Curved Reflectors for Shaped Beams (1948)

A method based upon conservation of energy and the simple laws of geometrical optics is described for the calculation of double-curvature surfaces to produce from a point source a shaped beam of arbitrary shape in one plane and uniformly narrow in the perpendicular planes. A specific application of the shaped-beam antenna is in connection with radar antennas for airborne navigational systems, for which the optimum elevation pattern is found empirically to be G(0) = Kcsc <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 0 cos 0. A reflector to produce from a given primary source the required pattern is the envelope of a family of paraboloids determined by a central-section curve which is adjusted to give the necessary distribution of energy for the shaped beam. A test for the single-valuedness of a computed surface is described. Patterns are shown for experimental antennas whose reflectors were computed by this method. It is demonstrated that some control of the antenna pattern can be achieved by proper motion of the antenna feed. A discussion of errors is included in an Appendix.
The politics of ethnicity in Central Europe (2001)

Bespreking van: Karl Cordel,The politics of ethnicity in Central Europe Londen:MacMillan Press ,1999 0-333-731719
A Glycomic Approach to Hepatic Tumors in N -acetylglucosaminyltransferase III (GnT-III) Transgenic Mice Induced by Diethylnitrosamine (DEN): Identification of Haptoglobin as a Target Molecule of GnT-III (2002)

A glycomic approach to the identification of target molecules in glycosyltransferase gene targeting mice is a promising strategy to understand the biological significance of glycosyltransferase genes in vivo. In order to understand the biological effects of N-acetylglucosaminyltransferase III (GnT-III) on tumor formation in the liver, diethylnitrosamine (DEN) induced tumor formation in the GnT-III transgenic mice was examined. Our findings show that the incidence of hepatic tumor could be dramatically suppressed. A glycomic approach using two-dimensional gel electrophoresis followed by lectin blot analysis and sequence analysis revealed that haptoglobin, a radical scavenger molecule in serum was heavily glycosylated in hepatic tumor-bearing GnT-III transgenic mice that had been treated with DEN. Immunoprecipitation followed by E4-PHA lectin blot analysis also confirmed that the bisecting GlcNAc, a product of GnT-III was added to haptoglobin molecules. Since the use of DEN is known to lead to the production of lipid peroxidation products which facilitate this reaction and haptoglobin is an acute phase reactant, acting as a radical scavenger against hemoglobin or iron stimulated lipid peroxidation, a relationship between the glycosylation of haptoglobin and the suppression of hepatoma development can not be ruled out. This paper is the first report that shows a relationship between the sugar chains of glycoproteins with radical scavenger activity and hepatocarcinogenesis.
Protein Tyrosine Phosphatase 1B: A Novel Target for Type 2 Diabetes and Obesity (2003)

The identification of autophosphorylation of the insulin receptor as a pivotal component in the signal transduction induced by insulin, initiated the hunt to identify the tyrosine phosphatase(s) that were responsible for regulating dephosphorylation, and thus inactivation of the receptor. Compelling evidence for the existence of an insulin receptor specific PTP has come from the remarkable phenotype of the PTP1B deficient mouse. PTP1B deficient mice display an insulin sensitive phenotype and are able to maintain glucose homeostasis with about half the level of circulating insulin. In response to insulin administration PTP1B deficient mice have a significant increase in insulin receptor phosphorylation in liver and muscle compared to wild type controls. Unexpectedly these animals were also resistant to diet induced obesity. These observations strongly support PTP1B as a negative regulator of insulin action, thereby making it an ideal therapeutic target for intervention in type 2 diabetes and obesity.
Automating metadata generation (2005)

In this paper, we focus on the development of a framework for automatic metadata generation. The first step towards this framework is the definition of an Application Programmer Interface (API), which we call the Simple Indexing Interface (SII). The second step is the definition of a framework for implementation of the SII. Both steps are presented in some detail in this paper. We also report on empirical evaluation of the metadata that the SII and supporting framework generated in a real-life context.
Human brain myelination and amyloid beta deposition in Alzheimer's disease (2007)

We hypothesized that myelin breakdown in vulnerable late-myelinating regions releases oligodendrocyte- and myelin-associated iron that promotes amyloid beta (A beta) oligomerization, its associated toxicity, and the deposition of oligomerized A beta and iron in neuritic plaques observed in Alzheimer's disease (AD). The model was tested by using published maps of cortical myelination from 1901 and recent in vivo imaging maps of A beta deposits in humans. The data show that in AD, radiolabeled ligands detect A beta deposition in a distribution that matches the map of late-myelinating regions. Furthermore, the strikingly lower ability of this imaging ligand to bind A beta in animal models is consistent with the much lower levels of myelin and associated iron levels in rodents when compared with humans. The hypotheses derived from the "myelin model" are testable with current imaging methods and have important implications for therapeutic interventions that should be expanded to include novel targets such as oligodendrocytes, myelin, and brain iron.
FPGA oriented design of parity sharing RS codecs (2006)

Reed Solomon codes are widely used to protect the information from errors in transmission and storage systems. RS codes rely on arithmetic in finite, or Galois fields. Most of the RS coders are based on the field GF(2/sup 8/), using a byte as a symbol and providing codewords up to 255 symbols. The drawback of this choice is the complexity of the arithmetic operation on the field GF(2/sup 8/), in particular with respect to fields with less number of elements, like GF(2/sup 4/). The use of the GF(2/sup 4/) field provides codewords up to 15 symbols. To supersede this limitation, parity sharing RS codecs has been proposed recently, even if no hardware implementation has been provided. In this paper, we analyze the hardware implementation of this kind of codes, providing a comparison with a standard RS code with the same code rate, and showing that the implementation is comparable in terms of area and there is a gain in terms of speed, in particular when the target technology is a LUT based FPGA.
A mode-locked ytterbium doped holey fiber laser (2001)

We describe what we believe to be the first mode-locked fiber laser based on holey optical fiber. The laser employs frequency-shifted feedback as the mode-locking mechanism, generates ~15ps pulses at 60 MHz, and is tunable from 1030nm-1050nm.
An ultrasonic multielement sensor system for position invariant object identification (1994)

This paper describes an ultrasonic sensor system for application in air that is capable of recognizing workpieces with size up to 20 mm, independently of their position and orientation, with high reliability. The 4×4 Transducer Matrix signals are first processed with a simplified reconstruction algorithm that leads to position invariant axial profiles of the object reflectivity. A broadband holographic reconstruction is then performed for those object planes that are reflecting the main signal energy. The Zernike Moments of the resulting cross-sectional patterns and features of the reflectivity profiles are fed in a 3-layered perceptron network. The system has been tested with a set of measuring data from 25 typical workpieces. Even though some objects have very similar reflection properties, it is possible to identify the objects in an area of 25×25 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> independently of their position and orientation with a recognition rate higher than 99%
Specific β <sub>2</sub> AR Blocker ICI 118,551 Actively Decreases Contraction Through a G <sub>i</sub> -Coupled Form of the β <sub>2</sub> AR in Myocytes From Failing Human Heart (2002)

We hypothesize that ICI 118,551 binding directs the beta(2)AR to a G(i)-coupled form and away from the G(s)-coupled form (ligand-directed trafficking). ICI 118,551 effectively acts as an agonist at the G(i)-coupled beta(2)AR, producing a direct negative inotropic effect. Conditions where beta(2)ARs are present and G(i) is raised (failing human heart, TGbeta(2) mouse heart) predispose to the appearance of the negative inotropic effect.
CNN-SVO: Improving the Mapping in Semi-Direct Visual Odometry Using Single-Image Depth Prediction (2018)

Reliable feature correspondence between frames is a critical step in visual odometry (VO) and visual simultaneous localization and mapping (V-SLAM) algorithms. In comparison with existing VO and V-SLAM algorithms, semi-direct visual odometry (SVO) has two main advantages that lead to state-of-the-art frame rate camera motion estimation: direct pixel correspondence and efficient implementation of probabilistic mapping method. This paper improves the SVO mapping by initializing the mean and the variance of the depth at a feature location according to the depth prediction from a single-image depth prediction network. By significantly reducing the depth uncertainty of the initialized map point (i.e., small variance centred about the depth prediction), the benefits are twofold: reliable feature correspondence between views and fast convergence to the true depth in order to create new map points. We evaluate our method with two outdoor datasets: KITTI dataset and Oxford Robotcar dataset. The experimental results indicate that the improved SVO mapping results in increased robustness and camera tracking accuracy.
Microgeometry of igneous rocks: Using maximum entropy inversion of elastic and transport properties (1986)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1986Microgeometry of igneous rocks: Using maximum entropy inversion of elastic and transport propertiesAuthors: Philippe DoyenPhilippe DoyenStanford Universityhttps://doi.org/10.1190/1.1892949 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1892949FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1986ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1986 Pages: 715 publication data© 1986 Copyright © 1986 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 07 Mar 2005 CITATION INFORMATION Philippe Doyen, (1986), "Microgeometry of igneous rocks: Using maximum entropy inversion of elastic and transport properties," SEG Technical Program Expanded Abstracts : 7-9. https://doi.org/10.1190/1.1892949 Plain-Language Summary PDF DownloadLoading ...
Mineral-Coated Polymer Membranes with Superhydrophilicity and Underwater Superoleophobicity for Effective Oil/Water Separation (2013)

Oil-polluted water is a worldwide problem due to the increasing industrial oily wastewater and the frequent oil spill accidents. Here, we report a novel kind of superhydrophilic hybrid membranes for effective oil/water separation. They were prepared by depositing CaCO3-based mineral coating on PAA-grafted polypropylene microfiltration membranes. The rigid mineral-coating traps abundant water in aqueous environment and forms a robust hydrated layer on the membrane pore surface, thus endowing the membranes with underwater superoleophobicity. Under the drive of either gravity or external pressure, the hybrid membranes separate a range of oil/water mixtures effectively with high water flux (>2000 L m(-2) h(-1)), perfect oil/water separation efficiency (>99%), high oil breakthrough pressure (>140 kPa) and low oil fouling. The oil/water mixtures include not only free mixtures but also oil-in-water emulsions. Therefore, the mineral-coated membrane enables an efficient and energy-saving separation for various oil/water mixtures, showing attractive potential for practical oil/water separation.
Characterization of visually similar diffuse diseases from B-scan liver images with the nonseparable wavelet transform (2002)

This paper describes the application of the nonseparable wavelet decomposition for the discrimination of diffuse diseases of liver. The proposed feature extraction algorithm uses the filter bank performing the quincunx transform and characterizes textures by a set of channel variances estimated at the output of each filter. Classification experiments on a set of three different tissue types show that this approach could be a reliable method for analysis of B-scan liver images.
High-throughput Screening Identifies Aclacinomycin as a Radiosensitizer of EGFR-Mutant Non-Small Cell Lung Cancer (2013)

The endoplasmic reticulum (ER) provides a specialized environment for the folding and modification of trans-membrane proteins, including receptor tyrosine kinases (RTKs), which are vital for the growth and survival of malignancies. To identify compounds which disrupt the function of the ER and thus could potentially impair cancer cell survival signaling, we adapted a set of glycosylation-sensitive luciferase reporters for the development and optimization of a cell-based high-throughput screen (HTS). Secondary screens for false-positive luciferase activation and tertiary lectin-based and biochemical analyses were also devised for compound triage. Through a pilot screen of 2802 compounds from the National Cancer Institute (NCI) chemical libraries, we identified aclacinomycin (Acm) as a compound that preferentially affects ER function. We report that Acm reduces plasma membrane expression of glycoproteins including epidermal growth factor receptor (EGFR) and Met but does not inhibit N-linked glycosylation or generalized protein translation. Fluorescence microscopy co-localization experiments were also performed and demonstrated Acm accumulation in the ER in further support of the overall HTS design. The consequences of Acm treatment on cell survival were analyzed through clonogenic survival analysis. Consistent with the reduction of EGFR levels, pretreatment with Acm sensitizes the EGFR-mutant non-small cell lung cancer (NSCLC) cell lines HCC827 and HCC2935 to ionizing radiation and did not affect the sensitivity of the RTK-independent and KRAS-mutant A549 NSCLC cell line. Thus, Acm and similar compounds targeting the ER may represent a novel approach for radiosensitizing tumor cells dependent on RTK function.
Regulation of Gelatinase Production in Metastatic Renal Cell Carcinoma by Organ‐specific Fibroblasts (1994)

We have recently established a human renal cell carcinoma KG-2 line that is tumorigenic in the subcutis (ectopic) and kidney (orthotopic) of nude mice but spontaneously metastasizes to the lung only after orthotopic implantation. KG-2 cells growing in the kidney (orthotopic) and lung metastases secreted higher levels of gelatinase than did cells growing in the subcutis (ectopic). We examined whether organ-specific fibroblasts play a role in the regulation of gelatinase production and invasion by renal carcinoma cells. The gelatinase level in the culture supernatants of KG-2 cells was increased by their cultivation with mouse kidney or lung fibroblasts. In contrast, cocultivation of KG-2 cells with mouse skin fibroblasts resulted in a significant reduction of gelatinase activity. Similar results were obtained by culturing KG-2 cells in the media conditioned by the different mouse fibroblasts. We, therefore, investigated effects on KG-2 cells of cytokines and growth factors known to be produced by fibroblasts of various origins. Of ten cytokines and growth factors tested, basic fibroblast growth factor, hepatocyte growth factor, and transforming growth factor-beta 1 (TGF-beta 1) stimulated gelatinase expression by the cultured KG-2 cells. Parallel immunohistochemical analyses revealed that mouse kidney and lung fibroblasts produced higher levels of TGF-beta 1 than did skin fibroblasts. These results indicate that gelatinase production by KG-2 renal cell carcinoma cells is influenced by the organ microenvironment. Specifically, organ-specific fibroblasts regulate the production of degradative enzymes by KG-2 cells and, hence, profoundly influence their invasive and metastatic capacity.
Detection and classification of impact-induced damage in composite plates using neural networks (2002)

Artificial neutral networks (ANN) can be used as an online health monitoring systems (involving damage assessment, fatigue monitoring and delamination detection) for composite structures owing to their inherent fast computing speeds, parallel processing and ability to learn and adapt to the experimental data. The amount of impact-induced strain on a composite structure can be found using strain sensors attached to composite structures. Prior work has shown that strain-based ANN can characterize impact energy on composite plates and that strain signatures can be associated with damage types and severity. This paper reports the extension of this approach for damage classification using finite element analysis to simulate impact-induced strain profiles resulting from impact on composite plates. An ANN employing the backpropagation algorithm was developed to detect and classify this damage.
Thai type style recognition (2003)

Thai typed character recognition has been a very most popular research topic in Thailand. There are three commercial Thai OCR softwares available to the public at the present. But none of them can preserve the type styles of the original document image such as bold, italics, normal, and bold and italics styles into the output text file. This paper presents the technique for preserving the specified Thai type styles by applying a specific preprocessing with a supervised neural networks (NNs) learning algorithm. Experiments have been conducted and the results confirm that the proposed technique effectively preserves the type styles of Thai typed fonts from the original document image into the output text file.
Development of molecular and pharmacological switches for chimeric antigen receptor T cells (2019)

The use of chimeric antigen receptor (CAR) T cell technology as a therapeutic strategy for the treatment blood-born human cancers has delivered outstanding clinical efficacy. However, this treatment modality can also be associated with serious adverse events in the form of cytokine release syndrome. While several avenues are being pursued to limit the off-target effects, it is critically important that any intervention strategy has minimal consequences on long term efficacy. A recent study published in Science Translational Medicine by Dr. Hudecek's group proved that dasatinib, a tyrosine kinase inhibitor, can serve as an on/off switch for CD19-CAR-T cells in preclinical models by limiting toxicities while maintaining therapeutic efficacy. In this editorial, we discuss the recent strategies for generating safer CAR-T cells, and also important questions surrounding the use of dasatinib for emergency intervention of CAR-T cell mediated cytokine release syndrome.
Transcatheter radiofrequency perforation and stent implantation for palliation of pulmonary atresia in a 3060‐g infant (1995)

In a 3060-g infant with fibromuscular pulmonary atresia an open right ventricular outflow tract was created by means of interventional cardiological methods. Following two inadvertent perforations without sequelae or clinical symptoms, radiofrequency perforation and subsequent balloon dilatation were successfully performed. The implantation of a Palmaz iliac stent led to a predictable communication between the right ventricle and pulmonary artery.
Cluster-Based Multicast Transmission for Device-to-Device (D2D) Communication (2013)

The development of the storage capacity and electricity of handheld devices makes it possible to share multimedia data (e.g. video) through Device-to-Device (D2D) communication. In this paper, we present a cluster-based multicast transmission method for D2D communication with the target of decreasing the data distribution time. We consider the users who store multimedia data serve as cluster head (CH) and distribute data to the users around them in D2D multicast mode. The CHs and users in the system compose different clusters and there is only one CH in a cluster. We derive out outage capacity of a single cluster and establish a clustering selection model for the whole system. Since the clustering selection is a non-convex problem, we propose a practical clustering strategy with theoretical analysis using game theory. Simulation results show that the clustering strategy lowers the average transmission time effectively and applies to the situation of high user density.