gebhart/patrepeval huggingface dataset:
Measurement of Total Vitamin B12 and Holotranscobalamin, Singly and in Combination, in Screening for Metabolic Vitamin B12 Deficiency (2005)

HoloTC and total vitamin B12 have equal diagnostic accuracy in screening for metabolic vitamin B12 deficiency. Measurement of both holoTC and total vitamin B12 provides a better screen for vitamin B12 deficiency than either assay alone.
Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients. A randomized controlled comparison with zidovudine monotherapy. Lamivudine European HIV Working Group. (1996)

In zidovudine-experienced HIV-1-infected patients, combination treatment with lamivudine and zidovudine is well tolerated and provides greater and more sustained increases in CD4+ cell counts and decreases in viral load than continued zidovudine monotherapy.
Advanced Encryption Standard (2009)

In cryptography, the Advanced Encryption Standard (AES) is an encryption standard adopted by the U.S. government. The standard comprises three block ciphers, AES-128, AES-192 and AES-256, adopted from a larger collection originally published as Rijndael. Each AES cipher has a 128-bit block size, with key sizes of 128, 192 and 256 bits, respectively. The AES ciphers have been analyzed extensively and are now used worldwide, as was the case with its predecessor, the Data Encryption Standard (DES). AES was announced by National Institute of Standards and Technology (NIST) as U.S. FIPS PUB 197 (FIPS 197) on November 26, 2001 after a 5-year standardization process in which fifteen competing designs were presented and evaluated before Rijndael was selected as the most suitable . It became effective as a Federal government standard on May 26, 2002 after approval by the Secretary of Commerce. It is available in many different encryption packages. AES is the first publicly accessible and open cipher approved by the NSA for top secret information.
An Ion Thruster Module for Primary Propulsion Systems (1973)

The development of a 30 cm thruster module having the operational characteristics, weight, and structural integrity consistent with flight hardware is described. Elements of the program discussed in this paper are selection of an ion optical system design, development of the discharge chamber and its control, and the results of extensive performance mapping tests. The thruster system operates at 2750 sec specific impulse at 69% over-all efficiency and can be throttled from 2.0 A to 0.16 A beam current with a control system requiring a single electrical input. The 1 kV ion beam is formed by a high perveance, two grid ion optical system.
Bioaugmentation of UASB reactors with immobilized Sulfurospirillum barnesii for simultaneous selenate and nitrate removal (2009)

Whole-cell immobilization of selenate-respiring Sulfurospirillum barnesii in polyacrylamide gels was investigated to allow the treatment of selenate contaminated (790 microg Se x L(-1)) synthetic wastewater with a high molar excess of nitrate (1,500 times) and sulfate (200 times). Gel-immobilized S. barnesii cells were used to inoculate a mesophilic (30 degrees C) bioreactor fed with lactate as electron donor at an organic loading rate of 5 g chemical oxygen demand (COD) x L(-1) day(-1). Selenate was reduced efficiently (>97%) in the nitrate and sulfate fed bioreactor, and a minimal effluent concentration of 39 microg Se x L(-1) was obtained. Scanning electron microscopy with energy dispersive X-ray (SEM-EDX) analysis revealed spherical bioprecipitates of <or=2 microm diameter mostly on the gel surface, consisting of selenium with a minor contribution of sulfur. To validate the bioaugmentation success under microbial competition, gel cubes with immobilized S. barnesii cells were added to an Upflow Anaerobic Sludge Bed (UASB) reactor, resulting in earlier selenate (24 hydraulic retention times (HRTs)) and sulfate (44 HRTs) removal and higher nitrate/nitrite removal efficiencies compared to a non-bioaugmented control reactor. S. barnesii was efficiently immobilized inside the UASB bioreactors as the selenate-reducing activity was maintained during long-term operation (58 days), and molecular analysis showed that S. barnesii was present in both the sludge bed and the effluent. This demonstrates that gel immobilization of specialized bacterial strains can supersede wash-out and out-competition of newly introduced strains in continuous bioaugmented systems. Eventually, proliferation of a selenium-respiring specialist occurred in the non-bioaugmented control reactor, resulting in simultaneous nitrate and selenate removal during a later phase of operation.
Protein Interactions in Hydrophobic Charge Induction Chromatography (HCIC) (2005)

A quantitative understanding of how proteins interact with hydrophobic charge induction chromatographic resins is provided. Selectivity on this mode of chromatography for monoclonal antibodies as compared to other model proteins is probed by means of a linear retention vs pH plot. The pH-dependent adsorption behavior on this mode of chromatography for a hydrophobic, charged solute is described by taking into account the equilibrium between a hydrophobic, charged solute and an ionizable, heterocyclic ligand. By analogy, an equation that is seen to adequately describe macromolecular retention under linear conditions over a range of pH is developed. A preparative, nonlinear isotherm that can capture both pH and salt concentration dependency for proteins is proposed by using an exponentially modified Langmuir isotherm model. This model is seen to successfully simulate adsorption isotherms for a variety of proteins over a range of pHs and mobile phase salt concentrations. Finally, the widely differing retention characteristics of two monoclonal antibodies are used to derive two different strategies for improving separations on this mode of chromatography. A better understanding of protein binding to this class of resins is seen as an important step to future exploitation of this mode of chromatography for industrial scale purification of proteins.
New Inscriptions On Lead From Olbia (1995)

Abstract Inscriptions on lead plates form a distinct group in Greek Black Sea epigraphy. They include private messages containing information about the lives and condition of Greek settlers as well as more standard texts, such as incantations, which also widen our knowledge of the social and economic structure and legal practice of the Ionian apoikiai of the region. The two inscriptions published for the first time here are both spells, probably judicial and of the early Hellenistic period, and testify to the flourishing legal activity and business life of Olbia.
Praktijkcentrum Sterksel: bouwen aan de toekomst (2002)

PraktijkKompas Varkens sprak met K. Broekman (58), sinds 1969 bedrijfsleider van Praktijkcentrum Sterksel. Volgend jaar stopt hij waarschijnlijk. Vanaf het eerste begin is hij betrokken geweest bij de opbouw van Sterksel.
Selective Endothelin A Receptor Antagonists. 3. Discovery and Structure−Activity Relationships of a Series of 4-Phenoxybutanoic Acid Derivatives (1998)

The third in this series of papers describes our further progress into the discovery of a potent and selective endothelin A (ETA) receptor antagonist for the potential treatment of diseases in which a pathophysiological role for endothelin has been implicated. These include hypertension, ischemic diseases, and atherosclerosis. In earlier publications we have outlined the discovery and structure-activity relations of two moderately potent series of nonpeptide ETA receptor antagonists. In this paper, we describe how a pharmacophore model for ETA receptor binding was developed which enabled these two series of compounds to be merged into a single class of 4-phenoxybutanoic acid derivatives. The subsequent optimization of in vitro activity against the ETA receptor led to the discovery of (R)-4-[2-cyano-5-(3-pyridylmethoxy)phenoxy]-4-(2-methylphenyl)b utanoi c acid (12m). This compound exhibits low-nanomolar binding to the ETA receptor and a greater than 1000-fold selectivity over the ETB receptor. Data are presented to demonstrate that 12m is orally bioavailable in the rat and is a functional antagonist in vitro and in vivo of ET-1-induced vasoconstriction.
Inhibition of neuronal apoptosis by the cyclin‐dependent kinase inhibitor GW8510: Identification of 3′ substituted indolones as a scaffold for the development of neuroprotective drugs (2005)

Increasing evidence suggests that neuronal apoptosis is triggered by the inappropriate activation of cyclin-dependent kinases leading to an abortive re-entry of neurons into the cell cycle. Pharmacological inhibitors of cell-cycle progression may therefore have value in the treatment of neurodegenerative diseases in humans. GW8510 is a 3' substituted indolone that was developed recently as an inhibitor of cyclin-dependent kinase 2 (CDK2). We found that GW8510 inhibits the death of cerebellar granule neurons caused by switching them from high potassium (HK) medium to low potassium (LK) medium. Although GW8510 inhibits CDK2 and other CDKs when tested in in vitro biochemical assays, when used on cultured neurons it only inhibits CDK5, a cytoplasmic CDK that is not associated with cell-cycle progression. Treatment of cultured HEK293T cells with GW8510 does not inhibit cell-cycle progression, consistent with its inability to inhibit mitotic CDKs in intact cells. Neuroprotection by GW8510 is independent of Akt and MEK-ERK signaling. Furthermore, GW8510 does not block the LK-induced activation of Gsk3beta and, while inhibiting c-jun phosphorylation, does not inhibit the increase in c-jun expression observed in apoptotic neurons. We also examined the effectiveness of other 3' substituted indolone compounds to protect against neuronal apoptosis. We found that like GW8510, the VEGF Receptor 2 Kinase Inhibitors [3-(1H-pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one], {(Z)-3-[2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indol-2-one} and [(Z)-5-Bromo-3-(4,5,6,6-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one], the Src family kinase inhibitor SU6656 and a commercially available inactive structural analog of an RNA-dependent protein kinase inhibitor 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one, are all neuroprotective when tested on LK-treated neurons. Along with our recent identification of the c-Raf inhibitor GW5074 (also a 3' substituted indolone) as a neuroprotective compound, our findings identify the 3' substituted indolone as a core structure for the designing of neuroprotective drugs that may be used to treat neurodegenerative diseases in humans.
Throttle Body Fuel Injection (TBI) — An Integrated Engine Control System (1980)

<div class="htmlview paragraph">Presented is a technical description of the significant features of the General Motors developed Throttle Body Fuel Injection System in production on the 1980 Cadillac Eldorado and Seville passenger cars. TBI fuel system discussion is divided into the 69 kPa (10 psi) fuel system, injector performance, fuel pump, sensors, electronic control module and system fuel control philosophy based upon speed density.</div> <div class="htmlview paragraph">Since achievement of low operating pressure for the fuel injection system is a significant technical accomplishment, the TBI fuel system design to accommodate hot fuel conditions will be reviewed.</div>
Evaluation of a Monoclonal Antibody Blocking ELISA for the Detection of Group-specific Antibodies to Bluetongue Virus in Experimental and Field Sera (1988)

In order to overcome serological cross-reactions among orbivirus serogroups, which can hinder the accurate diagnosis of bluetongue virus (BTV) infection of livestock, a blocking ELISA (B-ELISA) incorporating a monoclonal antibody (20E9B7G2) with specificity for the BTV serogroup was developed. Experimental antisera raised to South African BTV serotypes 1 to 19 were tested in the B-ELISA and all blocked the binding of 20E9B7G2 to BTV antigen. The sensitivity and specificity of the assay was evaluated with a range of experimental and field sera and compared to a sensitive indirect ELISA (I-ELISA) for the detection of BTV-specific antibodies. The specificity of the B-ELISA was absolute for antibodies to BTV, showing no cross-reaction with experimental antisera to serotypes of the closely related orbivirus causing epizootic haemorrhagic disease of deer. The sensitivity of the B-ELISA exceeded that of the I-ELISA. In particular, the B-ELISA detected a BTV-specific antibody response much earlier after infection that the I-ELISA, while still exhibiting full sensitivity to BTV antibody titres several months after infection.
Effects of Very High Pressures on Glass (1953)

In contrast to other inorganic solids, glasses may be permanently compacted by application of pressures of the order of 104 to 105 atmospheres. This effect was studied on two simple oxide glasses (SiO2 and B2O3) and several silicate glasses. The effect of compacting was studied by measuring the densities, dimensions, and x-ray diffraction patterns. A definite threshold pressure is observed in vitreous silica and silicate glasses, under which no effect takes place and above which the collapse takes place readily. Vitreous boric oxide behaves in a different manner, collapsing gradually, starting at the lowest pressures. Vitreous boric oxide exhibits also plastic flow with subsequent strain hardening. X-ray diffraction measurements performed on vitreous silica and boric oxide indicate that the compacting proceeds on the atomic scale, leaving, however, the short-range order of the basic structural units unchanged. The density of compacted glass can be restored to the original value by annealing to sufficiently high temperatures. Activation energy of this process was determined in the case of vitreous boric oxide.
Serial Blood Water Estimations and in-Line Blood Viscometry: The Continuous Measurement of Blood Volume during Dialysis Procedures (1984)

It has been shown in vitro that serial measurements of blood water during ultrafiltration accurately reflect changing blood volume. It has been shown that minute changes in blood hydration produce detectable changes in blood viscosity. An 'in-line' capillary viscometer has been constructed which can be placed in parallel with an extracorporeal circuit to give a continuous semi-quantitative measure of blood viscosity during ultrafiltration or haemodialysis. By making serial measurements of blood water each 'viscometer curve' can be corrected to permit calculation of blood volume provided that the starting blood volume is known. Blood volume changes of less than 1% can be detected in vitro and provided that blood volume changes solely as a result of the removal or influx of water it can be measured continuously to within an accuracy of 4% for volume changes up to 30% irrespective of starting packed cell volume or blood water.
Minimally invasive precision brain access using prospective stereotaxy and a trajectory guide (2008)

Prospective stereotaxy, in combination with a trajectory guide, has been proven capable of efficiently and accurately targeting structures throughout the brain.
Taxonomy of Potyviruses: Current Problems and Some Solutions (1991)

There are two major requirements for potyvirus taxonomy; group-specific criteria and criteria which discriminate between distinct viruses and strains. This review discusses the relative merits in potyvirus taxonomy of molecular parameters, such as gene sequence data, nucleic acid hybridization, coat protein sequence data, or high-performance liquid chromatography peptide profiles, and phenotypic characteristics, such as particle morphology, host range, symptomatology, cross-protection, cytoplasmic inclusion morphology, and serology. Coat protein and gene sequence data are the most useful criteria, as they can be used to distinguish viruses from strains and to establish evolutionary relationships between groups of distinct potyviruses. This has led to the revised classification of some viruses and strains and to the clarification of previously conflicting and inconsistent biological properties. It has also provided a sound basis for subgrouping potyviruses. An analysis of the data supports the view that the potyvirus group, including the non-aphid-transmitted viruses, should be elevated to family status, that the vector transmission mode, which correlates with major sequence diversity, should define the four genera, and that distinct potyviruses correspond to species and their variants to strains.
Biologic therapies for chronic inflammatory bowel disease (2006)

Crohn's disease (CD) and ulcerative colitis (UC) make up the so-called chronic inflammatory bowel disease (IBD). Advances in the understanding of IBD pathophysiologic mechanisms in the last few years have allowed the development of novel therapies such as biologic therapies, which at least theoretically represent a more specific management of this disease with fewer side effects. Currently, the only effective and widely accepted biologic therapy for the treatment of intraluminal, fistulizing CD, both for remission induction and maintenance, is infliximab. The role of other monoclonal antibodies such as adalimumab is not clearly established. It could be deemed an alternative for patients with allergic reactions to infliximab, and for those with lost response because of anti-infliximab antibody development. However, relevant issues such as dosage and administration regimen remain to be established. Anti-integrin a4 therapies, despite encouraging results in phase-3 studies, are still unavailable, as their marketing authorization was held back in view of a number of reports regarding progressive multifocal leukoencephalopathy cases. Immunostimulating therapy may be highly relevant in the near future, as it represents a novel strategy against disease with the inclusion of granulocyte-monocyte colony-stimulating factors.Regarding ulcerative colitis, results from the ACT-1 and ACT-2 studies showed that infliximab is also useful for the management of serious UC flare-ups not responding to standard treatment, which will lead to a revision of therapeutic algorithms, where this drug should be given preference before intravenous cyclosporine. In the next few years, the role of anti-CD3 drugs (vilisilizumab), T-cell inhibiting therapies, and epithelial repair and healing stimulating factors will be established.
Assessment of Switched Communication Network Availability for State Estimation of Distribution Networks With Generation (2007)

Active management of complex distribution networks with distributed generation requires state estimation. As complete supervisory control and data acquisition systems are seldom available on 11-kV or lower voltage distribution networks, real-time measurements at remote points on 11-kV distribution networks are expensive. Therefore, the economical selection of a communication system for active management of distribution networks with distributed generation becomes an important issue. This paper presents the investigations into a leased communication system made of public-switched communication network channels for a distribution network state estimation application. It analyzes the effects of a different number of primary channels for real-time measurements on the distribution network state estimation accuracy. The leased communication system availability performance has also been analyzed and used to identify a number of reserve channels required to improve the leased system availability. The overall cost for improving the leased communication system availability has been calculated and compared with both a fiber-optic communication system and a power-line carrier communication system. The results show that the leased communication system is able to provide the lowest overall cost performance for the distribution network state estimation application.
Drilling Wastes Generation and Management Approach (2012)

Waste management is one of the problems facing the oil and gas industry. This has often thrown the industry into numerous challenges ranging from technological development to ensuring a clean and safe environment. Oil and gas well drilling processes generate large volume of drill cuttings and spent mud. Onshore and offshore operators have used a variety of methods to manage these drilling wastes. This paper discusses the basic concepts for managing waste generated during drilling operations and provides systematic approach for pro-active waste management practices. It addresses the various stages in drilling waste management, and emphasizes the phases of waste identification, minimization, treatment and disposal as integral parts of waste management process.
Application of DBM system to overlay verification and wiggling quantification for advanced process (2012)

With the shrinkage of semiconductor device scales, advanced semiconductor industries face tremendous challenges in process control. As lithography and etch processes are pushed to get smaller dimensions, the overlay and wiggling control are hot issues due to the limiting of pattern performance. Many chip makers are using Double Patterning Technology (DPT) process to overcome design rule limitations but they are also concerned about overlay control. In DPT process, obtaining accurate overlay data by measuring overlay marks with traditional metrology is difficult because of the difference of shape and position between cell pattern and overlay marks. Cell to overlay mark miss-match will occur when there is lens aberration or mask registration error. Therefore, the best way to obtain accurate overlay data without error is to measure the real cell itself. The overlay of the cell array using DPT process can be measured by analyzing the relative position of the 2nd exposed pattern to the 1st exposed pattern. But it is not easy to clearly distinguish a 1st layer and 2nd layer in a patterned cell array image using CD SEM. The Design Based Metrology (DBM)-system can help identify which cell pattern is a 1st or 2nd layer, so overlay error between the 1st and 2nd layers at DPT process can be checked clearly. Another noticeable problem in advanced processing is wiggling. The wiggling of a pattern become severe by the etch process and must be controlled to meet electrical characteristics of what the semiconductor device requires. The 1st stage of wiggling control is to understand the level of wiggling which is crucial to device performance. The DBM-system also can be used for quantification of wiggling by determining specially designed parameters. In this paper we introduce overlay verification and wiggling quantification through new methodology for advanced memory devices.
Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy (2011)

We validate specific binding activity of a fluorescence-labeled peptide to colorectal dysplasia in living mice using a miniature, flexible, fiber microendoscope that passes through the instrument channel of an endoscope. The microendoscope delivers excitation light at 473 nm through a fiber-optic bundle with outer diameter of 680 µm to collect en face images at 10 Hz with 4 µm lateral resolution. We applied the FITC-labeled peptide QPIHPNNM topically to colonic mucosa in genetically engineered mice that spontaneously develop adenomas. More than two-fold greater fluorescence intensity was measured from adenomas compared to adjacent normal-appearing mucosa. Images of adenomas showed irregular morphology characteristic of dysplasia.
Thick Lithium Metal Target for Fast Neutron Production (1973)

A high flux fast neutron was produced by the (d, n) reaction of a lithium metal target. A thick lithium layer for the target was prepared by a simple method of melt-coating on a copper plate. The fast neutron (>9 MeV) flux at a distance of 6mm from the target was (9.0±1.6)×l06 n/cm2·sec·μA with use of a 2.0 MeV deuteron beam. A flux of 2.7×109 n/cm2·sec was obtained by bombarding the target with the deuteron beam of 300 μA.