gebhart/patrepeval huggingface dataset:
Inhaled Nitric Oxide Pretreatment But Not Post-treatment Attenuates Ischemia-Reperfusion-induced Pulmonary Microvascular Leak  (1997)

Inhaled NO attenuates I/R-induced pulmonary microvascular leak, which requires sGC activation and may involve a mechanism independent of inhibition of leukocyte-endothelial cell interactions. In addition, INO is ineffective in reversing I/R-induced microvascular leak.
REVIEWS (1957)

REVIEWS Get access Articulate Energy. An Inquiry into the Syntax of English Poetry. By DONALD DAVIE. Pp. vii +173. London: Routledge & Kegan Paul, 1955. 18s. net. EDWIN MORGAN EDWIN MORGAN Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume VIII, Issue 30, 1957, Pages 212–214, https://doi.org/10.1093/res/VIII.30.212 Published: 01 April 1957
Simultaneous determination of 10 elements in wastewater, plasma, and bovine liver by inductively coupled plasma emission spectrometry with electrothermal atomization (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimultaneous determination of 10 elements in wastewater, plasma, and bovine liver by inductively coupled plasma emission spectrometry with electrothermal atomizationWilliam M. Blakemore, Patrick H. Casey, and William R. CollieCite this: Anal. Chem. 1984, 56, 8, 1376–1379Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ac00272a038https://doi.org/10.1021/ac00272a038research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Computer-based Information Systems for Decentralized Rural Development Administration: A Case Study in India (1992)

Administrative reform currently being undertaken in a number of developing countries is focusing on the introduction of microcomputers as a tool for the decentralization of rural development administration. Experience to date concerning these efforts reveals that the key determinants of successful implementation of the technology are associated with organizational factors rather than hardware and software. However, these factors have been inadequately addressed in the literature on information technology in developing countries and empirical research drawing on experience of individual projects in developing countries is needed. To this end, this paper describes the case of the Computerized Rural Information Systems Project (CRISP) which is a government initiative to promote decentralization of rural development management in India. The interaction between formal, government-approved guidelines for rural development management and informal practice at the local level is examined. The findings reveal that the diffusion of technology has not been accompanied with changes to local work, decision and administrative processes.
A tunable ultra-narrowband filter for subcarrier processing and optical monitoring (2004)

A tunable filter with power complementary outputs and optimal isolation is presented that operates on multiple tones. A triple-peak filter with sub-GHz bandwidth and over 25 dB isolation was realized with sub-milliwatt thermo-optic switching power.
Experimental motion sickness: efficacy of transdermal scopolamine plus ephedrine. (1981)

A double-blind, placebo-controlled study compared the efficacy of transdermal therapeutic system-scopolamine administered alone and combined with ephedrine sulfate given orally in doses of 12.5, 25, and 50 mg. Eight normal male students were exposed to stressful accelerations in a slow-rotation room after receiving 10 apparently identical treatments comprising the four drugs and six placebos. Efficacy of the drug was defined in terms of the placebo range and categorized as beneficial, inconsequential, or detrimental. None of the effects was detrimental. Overall beneficial effects were 60% for transdermal therapeutic system-scopolamine (plus placebo) and 57% for the three transdermal therapeutic system-scopolamine plus ephedrine combinations.
Multiple α‐tubulin isoforms in cilia and cytoskeleton of <i>Tetrahymena pyriformis</i> generated by post‐translational modifications (1991)

alpha-Tubulin microheterogeneity was studied in Tetrahymena pyriformis. Using two-dimensional electrophoretic analysis, we found between five and seven alpha-tubulin and four beta-tubulin isoforms in cilia and four or five alpha-tubulins and two beta-tubulins in cytoskeleton. Immunoblotting assay with anti-(acetyl alpha-tubulin) monoclonal antibody 6-11B-1 and [3H]acetate labelling revealed that the alpha-tubulin isoforms are post-translationally modified by acetylation. Our results also show that tubulins in the soluble cytoplasmic fraction are not acetylated. Nevertheless, a slight reaction with the antibody 6-11 B-1 can be observed in the taxol and vinblastine-treated cytoplasmic pool. Pulse/chase experiments using [35S]methionine during cell reciliation have demonstrated that the basic alpha-tubulin isoforms are converted into acidic isoforms in the absence of protein synthesis, suggesting that the basic alpha-tubulin is the precursor of the acidic forms which are found in cilia and cytoskeleton. In-vivo-translation selection demonstrated the existence of a single precursor molecule which corresponded to the most basic alpha-tubulin. Taken together, our results provide evidence for the existence of post-translational modifications, namely acetylation. Nevertheless, other post-translational mechanisms involved in the biosynthesis of microtubules of cilia and cytoskeleton are required to explain the whole alpha-tubulin heterogeneity.
Parachute Mortars; An Engineering Review (2008)

Parachute mortars are used to eject a parachute pack with sufficient energy to pass through a turbulent vehicle wake and sequentially deploying the parachute riser, suspension line s and canopy in an orderly manner. A brief history of parachute usage, advantages and disadvantages of parachute mortar usage, key design requirements and features, installation and operational considerations, and best test practices are discussed. Metho ds for powering mortars and first order ballistic equations are provided for preliminary systems analysis. Test procedures that validate a mortar for flight are discussed. I. Introduction Parachute mortars are used to eject a parachute pack from an ai r vehicl e such that it rapidly transits the pack through any turbulent wake and into relatively smooth air flow. In some applications the air vehicle may be tumbling or experiencing high rotational rates and the pack must be ejected clear of the air vehic le structure. A parachute mortar also acts as a storage location for the parachute pack until parachute deployment is commanded. Parachute mortars are used on a wide variety of flight vehicles for applications such as manned spacecraft return from orbit, planetary spacecraft deceleration and landing, unmanned Earth re -entry vehicles, aircraft spin/stall recovery, and recovery or flight termination of pilot less aircraft and missiles There are several other methods that may be used to deploy a parachute i ncluding tractor rockets, ejectable covers, drogue guns, and catapults. However these tend to be either more complicated, heavier, slower, or more costly. There have been no known operational failures of a parachute mortar to deploy a parachute.
<title>Thermal damage quantification from tissue birefringence image analysis</title> (1993)

Decreased collagen or cardiac muscle birefringence in transmission polarizing microscopy is an observable measure of damaged tissue concentration. Accordingly, monochrome images of thermally damaged tissue exhibiting decreased birefringence provide important information about the tissue thermal history, which is often extremely difficult to measure globally during an experiment. Thus, a damage quantification algorithm based on monochrome tissue images exhibiting decreased values corresponding to estimated temperature distributions. The algorithm consists of initially time-averaging several video frames of the microscopic tissue image to reduce additive noise components and an additional multiplicative correction for optical nonuniformities. Subsequently, morphological close-opening and mean filtering of the tissue image is performed using a unit gain arbitrarily-sized square template, followed by background subtraction and scaling, producing the components required for the damage computation according to the volume fraction kinetic damage model. The algorithm has been applied to tissue images derived from an experimental protocol generating approximately linear thermal gradients along the axis perpendicular to the tissue surface plane and constant temperatures in the plane parallel to the tissue surface. The resulting thermally exposed tissue specimens exhibit decreased birefringence in damaged regions which is quantified and delineated automatically by this algorithm. Give the damage value at a specified tissue position, the temperature was also estimated. These temperature estimates approximate finite difference method numerical models of the experiment.
An 8b CMOS video DAC (1985)

THIS PAPER WILL DESCRIBE an 8b CMOS video speed (35ns) digital-to-analog converter configured in a standard digital CMOS process, without post-process trimming.
Introduction to biosensors (2016)

Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics and biomedical research. A wide range of techniques can be used for the development of biosensors. Their coupling with high-affinity biomolecules allows the sensitive and selective detection of a range of analytes. We give a general introduction to biosensors and biosensing technologies, including a brief historical overview, introducing key developments in the field and illustrating the breadth of biomolecular sensing strategies and the expansion of nanotechnological approaches that are now available.
High performance 35 nm gate length CMOS with NO oxynitride gate dielectric and Ni salicide (2002)

The 35 nm gate length CMOS devices with oxynitride gate dielectric and Ni salicide have been fabricated to study the feasibility of higher performance operation. Nitrogen concentration in gate oxynitride was optimized to reduce gate current I/sub g/ and to prevent boron penetration in the pFET. The thermal budget in the middle of the line (MOL) process was reduced enough to realize shallower junction depth in the S/D extension regions and to suppress gate poly-Si depletion. Finally, the current drives of 676 /spl mu/A//spl mu/m in nFET and 272 /spl mu/A//spl mu/m in pFET at V/sub dd/=0.85 V (at I/sub off/=100 nA//spl mu/m) were achieved and they are the best values for 35 nm gate length CMOS reported to date.
Chenodeoxycholic acid stimulates the progression of human esophageal cancer cells: A possible mechanism of angiogenesis in patients with esophageal cancer (2006)

Bile acids are known to promote the growth of gastrointestinal cancer. However, the underlying mechanism remains unclear. We examined whether bile acids induce tumor growth via the cyclooxygenase (COX)-2 angiogenic pathway. In vitro, esophageal squamous cell carcinoma (ESCC) cells and esophageal adenocarcinoma cells were studied. Production of prostaglandin E2 (PGE2) and vascular endothelial growth factor (VEGF) in response to treatment with chenodeoxycholic acid (CDCA) was assessed by enzyme-linked immunosorbent assay (ELISA). COX-2 protein and VEGF protein were measured by immunoblot analysis, and COX-2 activity was measured by ELISA. In vivo, CDCA was administered to ESCC cell-bearing mice. Tumor tissues were analyzed immunohistochemically, and microvessel density was evaluated. Clinically, 134 patients with ESCC who underwent esophagectomy were studied. In vitro, CDCA induced the production of PGE2 and VEGF in dose- and time-dependent manners, and these effects were attenuated by a selective COX-2 inhibitor, mitogen-activated protein kinases inhibitor, or epidermal growth factor receptor inhibitor. CDCA-induced COX-2 in the cell lysate increased the secretion of VEGF into the culture medium. In vivo, CDCA markedly enhanced tumor growth and increased vascularization. Clinically, patients whose tumors expressed both COX-2 and VEGF had poor outcomes. Our results suggest that bile acids, important constituents of duodenal fluid, stimulate the development of human esophageal cancer by promoting angiogenesis via the COX-2 pathway.
Proton, electron, and hydrogen atom transfers from ions, radicals, and radical ions derived from substituted urazoles and triazolinediones (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton, electron, and hydrogen atom transfers from ions, radicals, and radical ions derived from substituted urazoles and triazolinedionesM. J. Bausch and B. DavidCite this: J. Org. Chem. 1992, 57, 4, 1118–1124Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/jo00030a017https://doi.org/10.1021/jo00030a017research-articleACS PublicationsRequest reuse permissionsArticle Views608Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensitivity, Resolution, and Linearity of the Scintillation Camera (1966)

Radioisotope cameras are relatively new instruments for imaging the distribution of γ-ray or positron-emitting isotopes in vivo. They produce pictures similar to those made by medical radioisotope scanners, showing the uptake of tracer compounds in tumors and organs. Cameras can produce pictures in much less time than scanners because of their higher sensitivity and their ability to view all parts of the subject continuously. In the scintillation camera described here, an array of 19 multiplier phototubes view a single, large, thin, sodium iodide crystal. From the relative amount of light seen by each phototube when a scintillation is produced, the position is determined in two dimensions and it is displayed as a point flash of light on an oscilloscope. Pictures are obtained by taking a time exposure of the oscilloscope screen. Pinhole or parallel multichannel collimation is used with γ-ray emitters, and coincidence techniques are used with positron emitters.
Study of Truck Driver Behavior for Design of Traffic Signal Yellow and Clearance Timings (2015)

Traffic signal violations by drivers are a leading contributor to crashes at signalized intersections. The yellow indication is used to inform drivers of an upcoming change in the status of the traffic signal. Yellow interval durations are currently calculated to provide dilemma zone protection for passenger cars. Because of differences in vehicle characteristics and driver characteristics, heavy trucks such as tractor trailers behave differently at the onset of a yellow indication. This paper characterizes the difference in driver behavior between truck and light-duty vehicles at the onset of the yellow indication and then revises the yellow timing procedures to address the truck requirements. A data set of 910 stop–go records was collected through the use of a truck driving simulator located at the Virginia Tech Transportation Institute. From the data collected, statistical models were created to model driver perception–reaction times and deceleration levels with a consideration of driver attributes and the time to the intersection at the onset of the yellow indication. The data collected, along with the statistical models developed, were compared with the data collected and the statistical models created by the same research organization in a study of passenger car drivers. Last, a Monte Carlo simulation was conducted to develop appropriate yellow indication timings to provide adequate dilemma zone protection for trucks.
A summary of an entomological survey of Kaduna District, Northern Nigeria (1916)

Kaduna, the future capital of Nigeria, is situated in the Northern Provinces, on the River Kaduna, at an elevation of roughly 2,200 feet. The present Kaduna is a small station (Kaduna Bridge) south of the river, but the capital now in the process of construction is some two or three miles to the north, near the small native town of Doka. Being instructed to make an Entomological Survey of the district, with especial reference to Glossina and the resulting presence of trypanosomes in cattle, I left Lagos on 30th July 1914, reaching Kaduna Bridge on 1st August.
Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma (1990)

NH2-terminal amino acid sequence of the pS2 protein produced and secreted by human gastric cancer cells, MKN-45, was determined to be identical to that of MCF-7 cells. A clone encoding pS2 protein was isolated from the cDNA library constructed from MKN-45 cells. The nucleotide sequence was identical to that of pS2 cDNA previously isolated from human breast cancer cells, MCF-7, except for one nucleotide in the 3' untranslated region. Thus, in this cell line, the pS2 gene product is translated and secreted as in MCF-7 cells. RNA blot hybridization analysis revealed that pS2 gene was expressed well in two (MKN-45 and KATO-III; derived from poorly differentiated adenocarcinoma) but not in three cell lines (MKN-1, MKN-28 and MKN-74; from well differentiated adenocarcinoma), suggesting that expression of the pS2 gene depends on the state of cell differentiation. These results suggest that pS2 is expressed in human gastric cancer cells in an estrogen-independent manner and is possibly associated with the malignant state of cells.
Robust set operations on polyhedral solids (1989)

An algorithm for performing regularized Boolean operation on polyhedral solids is described. Robustness is achieved by adding symbolic reasoning as a supplemental step to resolve possible numerical uncertainty. Additionally, numerical redundancy and numerical computation based on derived quantities are reduced as much as possible. Experience with an implementation of the algorithm, using a unit-cube example as a simple test object for robustness, is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A role for MKP3 in axial patterning of the zebrafish embryo (2004)

Fibroblast growth factors (FGFs) are secreted molecules that can activate the RAS/mitogen-activated protein kinase (MAPK) pathway to serve crucial functions during embryogenesis. Through an in situ hybridization screen for genes with restricted expression patterns during early zebrafish development, we identified a group of genes that exhibit similar expression patterns to FGF genes. We report the characterization of zebrafish MAP kinase phosphatase 3 (MKP3; DUSP6 - Zebrafish Information Network), a member of the FGF synexpression group, showing that it has a crucial role in the specification of axial polarity in the early zebrafish embryo. MKP3 dephosphorylates the activated form of MAPK, inhibiting the RAS/MAPK arm of the FGF signaling pathway. Gain- and loss-of-function studies reveal that MKP3 is required to limit the extent of FGF/RAS/MAPK signaling in the early embryo, and that disturbing this inhibitory pathway disrupts dorsoventral patterning at the onset of gastrulation. The earliest mkp3 expression is restricted to the future dorsal region of the embryo where it is initiated by a maternal beta-catenin signal, but soon after its initiation, mkp3 expression comes under the control of FGF signaling. Thus, mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning.
Genetic Analysis of an Incomplete<i>bio</i>Operon in a Biotin Auxotrophic Strain of<i>Bacillus subtilis</i>Natto OK2 (2004)

We describe the genetic analysis of the bio operon of the biotin auxotrophic Bacillus subtilis natto OK2 strain. The OK2 strain would only cross-feed with the Escherichia coli bioB mutant and also grew well in medium containing dethiobiotin. Sequencing analysis revealed two significant genetic alterations in the bioW and bioF genes within the bio operon of the OK2 strain. Complementation analysis with B. subtilis 168 bio mutants demonstrated that only the bioB gene could complement, but other bio operon genes could not. A bio(+) transformant, isolated from an OK2 strain, has biotin autotrophy.