gebhart/patrepeval huggingface dataset:
Solar optics: light as energy; energy as light (1980)

a prominent characteristic of earth-sheltered and underground buildings, as well as buildings designed to accommodate more uses within the same perimeters, is the prominence of interior space without direct access to natural light and view opportunities. Solar Optics, a technique for illuminating interior spaces with natural light, offers a way to satisfy the well-documented human affinity for natural light. The system, which uses a heliostat to track the sun and lenses and mirrors to direct the light to remote interior spaces, is more efficient than converting solar radiation into electricity. Through the use of cold mirrors, it is also possible to separate the infrared portion of the spectrum from visible light, thereby creating a cool light source that can reduce a building's space cooling demand. Solar Optics also offers energy savings by transmitting light through a small aperture, as opposed to a large window. Several design problems must still be addressed. The system will be demonstrated in a new building at the University of Minnesota. Because this is a limited demonstration, it does not include the integration of a natural light system with a central source light system...another promising application of Solar Optics.
Anti-Peptide Antibody Blocks Peptide Binding to MHC Class I Molecules in the Endoplasmic Reticulum (2001)

The finding that MHC class I molecules are physically associated with the TAP transporter has suggested that peptides may be directly transported into the binding groove of the class I molecules rather than into the lumen of the endoplasmic reticulum (ER) where they subsequently would encounter class I molecules by diffusion. Such a mechanism would protect peptides from peptidases in the ER and/or escaping back into the cytoplasm. However, we find that an anti-peptide Ab that is cotranslationally transported into the ER prevents TAP-transported peptides from being presented on class I molecules. The Ab only blocks the binding of its cognate peptide (SIINFEKL) but not other peptides (KVVRFKDL, ASNENMETM, and FAPGNYPAL). Therefore, most TAP-transported peptides must diffuse through the lumen of the ER before binding stably to MHC class I molecules.
New Method for Computing the Moving Average (1915)

(1915). New Method for Computing the Moving Average. Quarterly Publications of the American Statistical Association: Vol. 14, No. 112, pp. 798-800.
Synthesis of Novel Phosphoramidite Building Blocks from Pentaerythritol (2003)

The synthesis of four types of phosphoramidites containing various protecting groups (DMTr, TBDMS, Lev) has been achieved starting from pentaerythritol. The protecting groups can be deprotected selectively in an orthogonal manner.
Soluble CD30: A serum marker for Epstein–Barr virus‐associated lymphoproliferative diseases (2010)

The soluble form of CD30 (sCD30), a member of tumor necrosis factor receptor superfamily, has been used as a marker of disease activity in various lymphomas. Epstein-Barr virus (EBV) is a potent stimulator of CD30 expression. The study aims to evaluate whether sCD30 can be used as a diagnostic marker for EBV-associated infectious mononucleosis (IM) and post-transplant lymphoproliferative disease (PTLD). Plasma from EBV seropositive healthy controls (N = 90), acute IM patients (n = 90), non-PTLD heart/lung transplant recipients (N = 30) and EBV-positive PTLD patients (N = 23) was tested for sCD30 using a commercially available ELISA kit. EBV DNA was tested by real time quantitative polymerase chain reaction assay. Significantly higher sCD30 levels were observed in acute IM patients (median 242.9 ng/ml) compared to EBV seropositive controls (median 15.7 ng/ml; P < 0.0001). These levels were highest in IM patients within 14 days of onset of illness. PTLD patients had significantly higher sCD30 levels (median 94 ng/ml) than healthy controls (P < 0.0001) and transplant patients (median 27 ng/ml; P = 0.0007). EBV DNA was detected mostly in acute IM and PTLD patients. In both cases there was a significant correlation between sCD30 and EBV DNA levels in plasma (P < 0.0001). This study demonstrates that sCD30 and EBV DNA levels can be used as potential markers for diagnosis of IM and PTLD.
Sustainable ICT in Agricultural Value Chains (2012)

For long-term sustainability, information and communication technologies for development (ICTD) must focus on reusability and scalability from the ground up. The Sustainable Bottom Billion Architecture is a technical ICTD architecture with successful sustainable replications in two ICTD projects in Africa's cashew and shea-nut farming value chains.
Development and Testing of a Two-UAV Communication Relay System (2016)

In the development of beyond-line-of-sight (BLOS) Unmanned Aerial Vehicle (UAV) systems, communication between the UAVs and the ground control station (GCS) is of critical importance. The commonly used economical wireless modules are restricted by the short communication range and are easily blocked by obstacles. The use of a communication relay system provides a practical way to solve these problems, improving the performance of UAV communication in BLOS and cross-obstacle operations. In this study, a communication relay system, in which a quadrotor was used to relay radio communication for another quadrotor was developed and tested. First, the UAVs used as the airborne platform were constructed, and the hardware for the communication relay system was selected and built up. Second, a set of software programs and protocol for autonomous mission control, communication relay control, and ground control were developed. Finally, the system was fully integrated into the airborne platform and tested both indoor and in-flight. The Received Signal Strength Indication (RSSI) and noise value in two typical application scenarios were recorded. The test results demonstrated the ability of this system to extend the communication range and build communication over obstacles. This system also shows the feasibility to coordinate multiple UAVs' communication with the same relay structure.
Individual-specific edge-network analysis for disease prediction (2017)

Predicting pre-disease state or tipping point just before irreversible deterioration of health is a difficult task. Edge-network analysis (ENA) with dynamic network biomarker (DNB) theory opens a new way to study this problem by exploring rich dynamical and high-dimensional information of omics data. Although theoretically ENA has the ability to identify the pre-disease state during the disease progression, it requires multiple samples for such prediction on each individual, which are generally not available in clinical practice, thus limiting its applications in personalized medicine. In this work to overcome this problem, we propose the individual-specific ENA (iENA) with DNB to identify the pre-disease state of each individual in a single-sample manner. In particular, iENA can identify individual-specific biomarkers for the disease prediction, in addition to the traditional disease diagnosis. To demonstrate the effectiveness, iENA was applied to the analysis on omics data of H3N2 cohorts and successfully detected early-warning signals of the influenza infection for each individual both on the occurred time and event in an accurate manner, which actually achieves the AUC larger than 0.9. iENA not only found the new individual-specific biomarkers but also recovered the common biomarkers of influenza infection reported from previous works. In addition, iENA also detected the critical stages of multiple cancers with significant edge-biomarkers, which were further validated by survival analysis on both TCGA data and other independent data.
Acoustic Emission Signals in Thin Plates Produced by Impact Damage (1999)

Acoustic emission (AE) signals created by impact sources in thin aluminum and graphite/epoxy composite plates were analyzed. Two different impact velocity regimes were studied. Low-velocity (less than 0.21 km/s) impacts were created with an airgun firing spherical steel projectiles (4.5 mm diameter). High-velocity (1.8 to 7 km/s) impacts were generated with a two-stage light-gas gun firing small cylindrical nylon projectiles (1.5 mm diameter). Both the impact velocity and impact angle were varied. The impacts did not penetrate the aluminum plates at either low or high velocities. For high-velocity impacts in composites, there were both impacts that fully penetrated the plate as well as impacts that did not. All impacts generated very large amplitude AE signals (1-5 V at the sensor), which propagated as plate (extensional and/or flexural) modes. In the low-velocity impact studies, the signal was dominated by a large flexural mode with only a small extensional mode component detected. As the impact velocity was increased within the low velocity regime, the overall amplitudes of both the extensional and flexural modes increased. In addition, a relative increase in the amplitude of high-frequency components of the flexural mode was also observed. Signals caused by high-velocity impacts that did not penetrate the plate contained both a large extensional and flexural mode component of comparable amplitudes. The signals also contained components of much higher frequency and were easily differentiated from those caused by low-velocity impacts. An interesting phenomenon was observed in that the large flexural mode component, seen in every other case, was absent from the signal when the impact particle fully penetrated through the composite plates.
On Variance Estimation with Imputed Survey Data (1996)

Abstract Unit nonresponse and item nonresponse both occur frequently in surveys. Unit nonresponse is customarily handled by weighting adjustment, whereas item nonresponse is usually treated by some form of imputation. In particular, deterministic or stochastic imputation is often used to assign values for missing item responses. We provide an account of some recent work on jackknife variance estimation based on adjusted imputed values, using only a single imputation and hence a single completed data set. We also present linearized versions of the jackknife variance estimators. We study both stratified simple random sampling and stratified multistage sampling. Existing computer programs for jackknife and linearization variance estimation can be modified to implement the proposed variance estimators without requiring the creation and permanent retention of supplemental data sets. But for secondary analyses, the completed data set must include information on response status for each item as well as on the imputation class.
Respiratory function of hyoid muscles and hyoid arch (1984)

The position of the hyoid arch suggests that it supports soft tissue surrounding the upper airway (UA) and can act to maintain UA patency. We also suspected that muscles inserting on the hyoid arch might show respiratory patterns of activity that could be affected by respiratory stimuli. To test these possibilities, we moved the hyoid arch ventrally in six anesthetized dogs either by traction on it or by stimulation of hyoid muscles. UA resistance was decreased 73 +/- (SE) 6% and 72 +/- 6% by traction and stimulation during expiration and 57 +/- 15% and 52 +/- 8% during inspiration. Moving averages of the geniohyoid (GH) and thyrohyoid (TH) obtained in six other dogs breathing 100% O2 showed phasic respiratory activity while the sternohyoid (SH) showed phasic respiratory activity in only two of these animals and no activity in four. With progressive hypercapnia, GH and TH increased as did SH when activity was already present. Airway occlusion at end expiration augmented and prolonged inspiratory activity in the hyoid muscles but did not elicit SH activity if not already present. Occlusion at end inspiration suppressed phasic activity in hyoid muscles for as long as in the diaphragm. After vagotomy activity increased and became almost exclusively inspiratory. Activity appeared in SH when not previously present. Duration and amplitude of hyoid muscle activity were increased with negative UA pressure and augmented breaths. We conclude that the hyoid arch and muscles can strongly affect UA flow resistance. Hyoid muscles show responses to chemical, vagal, and negative pressure stimuli similar to other UA muscles.
Behavioural responses by <i>Rhagoletis indifferens</i> (Dipt., Tephritidae) to sweet cherry treated with kaolin‐ and limestone‐based products (2010)

Abstract Kaolin‐ and limestone‐based products were compared for their effects on two behavioural responses, landing and oviposition, to sweet cherry by Rhagoletis indifferens Curran (Dipt., Tephritidae). Surround (95% calcined kaolin), Cocoon (100% hydrous kaolin), Eclipse (>97% limestone) and Purshade (62.5% limestone) were studied. Overall, in choice and no‐choice tests, Surround reduced landing and oviposition more than Cocoon, Eclipse and Purshade. However, all products significantly reduced landing and oviposition compared with untreated controls. In choice tests, high fly density increased the proportion of eggs laid in cherries treated with Surround, Cocoon, or Eclipse vs. cherries that were untreated when compared with low fly density. Applications of 3% followed by 6% Surround reduced landings and oviposition more than two applications of 10% Cocoon, Eclipse, or Purshade. Surround caused higher mortality than Cocoon and Eclipse. In the field, Surround reduced production of puparia from cherries by 32.3% to 100%, depending on the trees sprayed. Surround provided the best protection for cherries against R. indifferens , but limestone‐based products potentially might be modified to be oviposition deterrents. Consideration should be given to fly densities when using particle films to protect fruit.
Colloidal Transition-Metal-Doped ZnO Quantum Dots (2002)

Methods for introducing new magnetic, optical, electronic, photophysical, or photochemical properties to semiconductor nanocrystals are attracting intense applications-oriented interest. In this communication, we report the preparation and electronic absorption spectroscopy of colloidal ZnO DMS-QDs. Our synthetic procedure involves modification of literature methods known to yield highly crystalline and relatively monodisperse nanocrystals of pure ZnO to allow introduction of transition-metal dopants. We use ligand-field electronic absorption spectroscopy as a dopant-specific optical probe to monitor dopant incorporation during nanocrystal growth and to verify internal substitutional doping in Co2+:ZnO and Ni2+:ZnO DMS-QDs. To the best of our knowledge, these are the first free-standing oxide DMS-QDs reported. The synthesis of colloidal oxide DMS-QDs introduces a new category of magnetic semiconductor materials available for detailed physical study and application in nanotechnology.
Terahertz optical rectification from 〈110〉 zinc-blende crystals (1994)

We report the study of optically induced terahertz (THz) electromagnetic radiation from 〈110〉 oriented zinc-blende crystals. This work extends our previous studies of 〈100〉 and 〈111〉 GaAs. Excellent agreement between calculated results and experimental data indicates that, under conditions of moderate optical fluence and normal incidence on the unbiased sample, second-order optical rectification is the major nonlinear process that generates THz radiation.
Anti-Inflammatory and Proresolving Lipid Mediators (2008)

The popular view that all lipid mediators are pro-inflammatory arises largely from the finding that nonsteroidal anti-inflammatory drugs block the biosynthesis of prostaglandins. The resolution of inflammation was widely held as a passive event until recently, with the characterization of novel biochemical pathways and lipid-derived mediators that are actively turned on in resolution and that possess potent anti-inflammatory and proresolving actions. A lipid-mediator informatics approach was employed to systematically identify new families of endogenous local-acting mediators from omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid) in resolving exudates, which also contain lipoxins and aspirin-triggered lipoxins generated from arachidonic acid. Given their potent bioactions, these new chemical mediator families were termed resolvins and protectins. Here, we review the recent advances in our understanding of the biosynthesis and stereospecific actions of these new proresolving mediators, which have also proven to be organ protective and antifibrotic.
DC holding and dynamic triggering characteristics of bulk CMOS latchup (1983)

Improved models for bulk CMOS latchup holding and triggering characteristics are developed and verified experimentally in this work. The roles of collector and base branch resistances are shown to lead to an accurate model for the minimum voltage to sustain latchup, and to an improved understanding of strong versus weak layouts, respectively. New measurement techniques for model parameters are described and used to test the dc model. Latchup triggering by base region (substrate or well) lateral currents is considered in some detail, It is shown that both threshold current levels and minimum turn-on times exist, below which latchup will not occur. Supporting experimental evidence is presented for all of the models.
Deep Learning with Edge Computing for Localization of Epileptogenicity Using Multimodal rs-fMRI and EEG Big Data (2017)

Epilepsy is a chronic brain disorder characterized by the occurrence of spontaneous seizures of which about 30 percent of patients remain medically intractable and may undergo surgical intervention; despite the latter, some may still fail to attain a seizure-free outcome. Functional changes may precede structural ones in the epileptic brain and may be detectable using existing noninvasive modalities. Functional connectivity analysis through electroencephalography (EEG) and resting state-functional magnetic resonance imaging (rs-fMRI), complemented by diffusion tensor imaging (DTI), has provided such meaningful input in cases of temporal lobe epilepsy (TLE). Recently, the emergence of edge computing has provided competent solutions enabling context-aware and real-time response services for users. By leveraging the potential of autonomic edge computing in epilepsy, we develop and deploy both noninvasive and invasive methods for the monitoring, evaluation and regulation of the epileptic brain, with responsive neurostimulation (RNS; Neuropace). First, an autonomic edge computing framework is proposed for processing of big data as part of a decision support system for surgical candidacy. Second, an optimized model for estimation of the epileptogenic network using independently acquired EEG and rs-fMRI is presented. Third, an unsupervised feature extraction model is developed based on a convolutional deep learning structure for distinguishing interictal epileptic discharge (IED) periods from nonIED periods using electrographic signals from electrocorticography (ECoG). Experimental and simulation results from actual patient data validate the effectiveness of the proposed methods.
Embedding an Exoskeleton Hand in the Astronaut's EVA Glove: Feasibility and Ideas (2012)

This paper investigates the key factors associated to the realization of a hand exoskeleton to be embedded in an astronaut's EVA glove, in order to overcome the stiffness of the pressurized space suit. An overview regard ing the main constraints related to the realization of a hand exoskeleton for EVA suits is provided, as well as a preliminary concept analysis of possible solutions in terms of mechanical structure, actuators and sensors. Furthermore, analyses of human hand kinemat ics and of the characteristics of the EVA glove's stiffness are presented, as a basis for design and dimensioning of the exoskeleton. The future exoskeleton will be a co mp lex mechatronic system detecting the operator's movement through sensors, processing the acquired data and generating the motion through its actuation system.
Controlled release of nonionic compounds from poly(lactic acid)/cellulose nanocrystal nanocomposite fibers (2012)

Abstract Poly(lactic acid)(PLA)/cellulose nanocrystal nanocomposite fibers were prepared by electrospinning at elevated temperature. Columbia Blue, a nonionic hydrophobic dye with a molecular weight and partition coefficient that mimics a systemic agrichemical, was incorporated into the fibers as a model compound. The release of Columbia Blue into water displayed little burst release. Diffusion‐controlled release of Columbia Blue was significantly influenced by the hydrophobicity of the electrospun PLA nanocomposite fibers and followed Fickian diffusion kinetics. The release of Columbia Blue by degradation‐controlled mechanism followed zero‐order, time‐independent Case II kinetics ( n = 1.0). Increasing cellulose nanocrystal content in the fibers increased the fiber degradation rate and the Columbia Blue release rate. The plasticizing effect of Columbia Blue on the thermal properties of the electrospun nanocomposite fibers showed the miscibility of Columbia Blue inside the electrospun nanocomposite fibers. A greenhouse trial confirmed the anticipated trends of higher pesticide dosage causing higher whitefly mortality percentage. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2013
Development and implementation of practice guidelines (Part 1). (1994)

Development and implementation of practice guidelines should be a team effort that includes pharmacists, the medical staff, and hospital administration. Described in this article are the steps involved in developing and successfully implementing practice guidelines. Also briefly presented are some practice guidelines developed by the staff at Cedars-Sinai Medical Center for the use of ondansetron in the post-op setting, colony stimulating factors, and sumatriptan for the treatment of migraine. Finally, discussion of a few practice guidelines that are in the implementation phase and future directions with regard to evolution of practice guidelines are presented.
N‐methyl‐D‐aspartate‐mediated glutamate toxicity in the developing rabbit retina (1997)

Extracellular levels of endogenous glutamate are relatively high in the developing rabbit retina but nonetheless appear to promote cell survival and developmental processes at concentrations considered toxic in the adult. We wished to examine the development of retinal susceptibility to glutamate toxicity as well as the protective effects of two N-methyl-D-aspartate (NMDA) antagonists, 2-amino-5-phosphono-5-valeric acid (APV) and dextromethorphan (Dex), and the nitric oxide synthase (NOS) inhibitor, NG-methyl-L-arginine (metARG). One day in vitro retinal explants of adult and neonatal rabbits were incubated with various agonists and antagonists, and stained with trypan blue to visualize necrotic cells. The density of the necrotic cells was analyzed using the Zeiss Videoplan 2. Immature neurons were approximately 10-fold less sensitive to NMDA toxicity compared to the adult. Although both NMDA antagonists and met ARG provided marked protection for adult retinal neurons against glutamate toxicity, the modest susceptibility of the immature neuron was blocked only by Dex and not APV or metARG. At least two factors may contribute to the ability or the neonatal retina to survive in the presence of high levels of endogenous extracellular glutamate. First, the 10-fold developmental increase in NMDA toxicity occurs simultaneously with a 12–15-fold downregulation of extracellular glutamate, probably through the actions of maturing Muller cells. Second, the NMDA/NO excitotoxic pathway may not be active at birth since an NOS inhibitor had little effect at this stage and our previous morphological data demonstrate that NOS-containing cells are not present in their mature configuration until the second postnatal week. J. Neurosci. Res. 47:416–426, 1997. © 1997 Wiley-Liss, Inc.