gebhart/patrepeval huggingface dataset:
Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource Database (2016)

Antibodies are used extensively for a wide range of basic research and clinical applications. While an abundant and diverse collection of antibodies to protein antigens have been developed, good monoclonal antibodies to carbohydrates are much less common. Moreover, it can be difficult to determine if a particular antibody has the appropriate specificity, which antibody is best suited for a given application, and where to obtain that antibody. Herein, we provide an overview of the current state of the field, discuss challenges for selecting and using antiglycan antibodies, and summarize deficiencies in the existing repertoire of antiglycan antibodies. This perspective was enabled by collecting information from publications, databases, and commercial entities and assembling it into a single database, referred to as the Database of Anti-Glycan Reagents (DAGR). DAGR is a publicly available, comprehensive resource for anticarbohydrate antibodies, their applications, availability, and quality.
Wireless Power Transfer for Miniature Implantable Biomedical Devices (2019)

Miniature implantable electronic devices play increasing roles in modern medicine. In order to implement these devices successfully, the wireless power transfer (WPT) technology is often utilized because it provides an alternative to the battery as the energy source; reduces the size of implant substantially; allows the implant to be placed in a restricted space within the body; reduces both medical cost and chances of complications; and eliminates repeated surgeries for battery replacements. In this work, we present our recent studies on WPT for miniature implants. First, a new implantable coil with a double helix winding is developed which adapts to tubularly shaped organs within the human body, such as blood vessels and nerves. This coil can be made in the planar form and then wrapped around the tubular organ, greatly simplifying the surgical procedure for device implantation. Second, in order to support a variety of experiments (e.g., drug evaluation) using a rodent animal model, we present a special WPT transceiver system with a relatively large power transmitter and a miniature implantable power receiver. We present a multi-coil design that allows steady power transfer from the floor of an animal cage to the bodies of a group of free-moving laboratory rodents.
<sup>13</sup>C NMR and IR Evidence for the Two Types of Copper(I) and (II) Complexes with 5-Pyrido-1,4-benzodiazepin-2-ones (1994)

Abstract 5-Pyrido-1,4-benzodiazepin-2-onederivatives 1–9 are investigated as potential 1,4-N,N-bidentate ligands in copper(I) and (II) complexes. On the basis of 13C NMR and IR spectra two types of complexation are revealed. In the first ones, ligands 1–5behave as l,4-N,N-bidentates, whereas their 4,5-dihydro congeners 6–9 unexpectedly form N,O-bidentate complexes, engaging carbonyl oxygen and pyridine nitrogen as the coordination sites.
A Topology Paradigm for Metal‐Organic Zeolites (2003)

Unprecedented coordination polymers of hexagonal tungsten bronze topology represent a new type of metal–organic zeolites: the compounds have a microporous structure, they are thermally stable and are capable of the reversible adsorption of dichloromethane (see picture). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z50534_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon? (2013)

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and has few effective therapies. It is characterized by anomalous and persistent inflammation, both local and systemic. Neutrophilic inflammation predominates in the COPD airway wall and lumen, but, despite the presence of abundant innate immune cells, the progressive clinical course of the disease is punctuated by recurrent infection-driven exacerbations. An extensive body of evidence (from cell culture to murine models and finally to the susceptibility of human patients with α1-antitrypsin deficiency to develop COPD) implicates neutrophil elastase and other neutrophil-derived proteases as key mediators of the tissue damage and relentless decline in lung function that occurs in this condition. In addition to the well recognized role of cytokines in modulating neutrophil function and survival, it has recently become apparent that hypoxia can influence neutrophil function, with impaired killing of pathogenic bacteria, enhanced release of proteases, and delayed apoptosis. This destructive neutrophil phenotype is predicted to be highly detrimental in the setting of the COPD microenvironment.
Development and evaluation of a Web-based signal and speech processing laboratory for distance learning (2002)

We describe an Internet-based signal processing laboratory that provides hands-on learning experiences in distributed learning environments. The laboratory is based on an object-oriented Java/sup TM/ tool called Java Digital Signal Processing (J-DSP). J-DSP has been developed at Arizona State University (ASU) and is being used for a virtual laboratory in a senior-level DSP course. J-DSP is written as a platform-independent Java applet that resides on the Web and is thereby accessible by all students through the use of a Web browser. J-DSP has a rich suite of signal processing functions that facilitate interactive on-line simulations of modern statistical signal and spectral analysis algorithms, filter design tools, QMF banks, and state-of-the-art vocoders. J-DSP is accompanied by administrative software tools for secure Internet-based lab-report submission and evaluation including servlets for maintaining Web-based grade books. A series of J-DSP laboratory exercises has been developed and delivered using the ASU distance learning facilities. Student evaluations as well as assessments by experts have been compiled and preliminary results are quite encouraging.
Self-Aggregation of Surfactant Protein A (2000)

Environmental factors of physiological relevance such as pH, calcium, ionic strength, and temperature can affect the state of self-aggregation of surfactant protein A (SP-A). We have studied the secondary structure of different SP-A aggregates and analyzed their fluorescence characteristics. (a) We found that self-aggregation of SP-A can be Ca(2+)-dependent. The concentration of Ca(2+) needed for half-maximal self-association (K(a)(Ca)()2+) depended on the presence of salts. Thus, at low ionic strength, K(a)(Ca)()2+ was 2.3 mM, whereas at physiological ionic strength, K(a)(Ca)()2+ was 2.35 microM. Circular dichroism and fluorescence measurements of Ca(2+)-dependent SP-A aggregates indicated that those protein aggregates formed in the absence of NaCl are structurally different from those formed in its presence. (b) We found that self-aggregation of SP-A can be pH-dependent. Self-aggregation of SP-A induced by H(+) was highly influenced by the presence of salts, which reduced the extent of self-association of the protein. The presence of both salts and Ca(2+) attenuated even more the effects of acidic media on SP-A self-aggregation. (c) We found that self-aggregation of SP-A can be temperature-dependent. At 20 degrees C, SP-A underwent self-aggregation at physiological but not at low ionic strength, in the presence of EDTA. All of these aggregates were dissociated by either adding EDTA (a), increasing the pH to neutral pH (b), or increasing the temperature to 37 degrees C (c). Dissociation of Ca(2+)-induced protein aggregates at low ionic strength was accompanied by an irreversible loss of both SP-A secondary structure and SP-A-dependent lipid aggregation properties. On the other hand, temperature-dependent experiments indicated that a structurally intact collagen-like domain was required for either Ca(2+)- or Ca(2+)/Na(+)-induced SP-A self-aggregation but not for H(+)-induced protein aggregation.
The Problem of Indirect Defamation: Omission of Material Facts, Implication, and Innuendo (1993)

This Comment devotes itself to a discussion of indirect defamation law in cases involving media defendants, defined as news reporting organizations, such as newspapers or television stations, that are defendants in defamation actions.Neither the discussion nor the model standard is intended to apply to defamation cases brought against non-media defendants.10 William L. Prosser, Libel Per Quod, 46 Va L Rev 839, 841 (1960).However, proof of damage was not required for libel per quod when the publication fell into one of four cate-
Direct attachment of fibronectin to tresyl chloride‐activated titanium (2003)

The aim of this study was to bind fibronectin directly to a titanium surface treated with tresyl chloride (2,2,2-trifluoroethanesulfonyl chloride) for the development of a strong connection of a dental implant to subepithelial connective tissues and/or peri-implant epithelia. Basic terminal OH groups of mirror polished titanium were allowed to react with tresyl chloride at 37 degrees C for 2 days. The tresylated titanium disk was then immersed into a fibronectin/phosphate-buffered saline solution for 24 h at 37 degrees C. The activation reaction of the basic OH of titanium with tresyl chloride was confirmed by S2p, F1s, and O1s spectra using X-ray photoelectron spectroscopy and -O-S-O2- bonds using Fourier transform infrared reflection-absorption spectroscopy. After the reaction of fibronectin with titanium, the X-ray photoelectron spectroscopy revealed the remarkable effect of the activation of terminal OH groups with the tresyl chloride treatment. The N1s peak derived from the attached fibronectin still remained after 60 s of argon-ion sputtering after tresyl chloride treatment. In contrast, the N1s peak of the specimen not treated with tresyl chloride almost disappeared after only 10 s of argon-ion etching. Fibronectin, a well-known cell-adhesive protein, could easily be attached to the titanium surface by use of the tresyl chloride activation technique.
Polygenes and Modifier Genes for Tetracycline and Penicillin Resistance in Neisseria gonorrhoeae (1980)

The genetic basis for spontaneous resistance to tetracyline (Tet) and penicillin (Pen) in Neisseria gonorrhoeae was investigated. Tet and pen are polygenes which confer small but distinct levels of resistance to Tet and Pen, respectively. Mtr is a multiple-drug resistance polygene which increases resistance to Tet and Pen (as well as to other unrelated antibiotics). Tem is a modifier gene affecting resistance toTet and Pen. Pem is a modifier gene for Pen resistance. The following gene combinations code for resistance to five antibiotics: tet, mtr and tem for Tet; pen, mtr, pem and tem for Pen; tet, tem and mtr for doxycycline; pen and pem for ampicillin; pen, pem and mtr for nafcillin.
MUDRAPLAN—A DSS for Media Planning: From Design to Utilization (1992)

In advertising, media planning consists of deciding where to advertise, what elements of the medium to choose, and how many insertions should appear in each vehicle. The parameters planners consider are cost and reach. Because the relationships between the variables that make up a media plan are nonlinear and often irregular, media planners have difficulty making good decisions consistently. Also it may be difficult to quantify such parameters as impact and recall. We have mathematically modeled the media-planning problem for print media as a nonlinear decision problem. In preliminary use of our DSS, a media agency saved 20 to 30 percent and obtained a solution very different from those generated by traditional trial and error methods.
Recent Developments in Maser Devices and Materials (1962)

The properties of crystals used in solid state masers are discussed. A table is presented summarizing this information for present maser materials. It is pointed out that further material research needs to be done to improve the performance of masers and extend their frequency range.
Examining the impact of phonics intervention on secondary students’ reading improvement (2008)

This paper describes an action research project focusing on the effects of a phonics intervention on the reading fluency of high school students. Phonics instruction is normally associated with earlier stages of learners’ reading development. If it is an effective tool for early readers, then it would seem that struggling readers at the high school level might benefit from an intervention program that used a phonics‐based approach. Pre‐testing identified the decoding skills that students were unfamiliar with and the phonics intervention addressed the identified areas of need. Students were tested three times over time: one as a baseline measure, the second after a seven‐week intervention was completed, and the last one year after the completion of the initial intervention. Two measures were recorded for each of the three time spots: the first was Raw Score and the second was Reading Grade Level. Results showed that there was a significant change over time in the three measures for both Raw Score and the Reading Grade Level. All students benefited significantly from the phonics intervention. The results of this intervention encourage the use of structured phonics with struggling high school age students as a strategy to improve their reading fluency.
Diagnostic and epidemiological features of Lawsonia intracellularis enteropathy in 2 foals. (2006)

Two clinical cases of equine proliferative enteropathy are described. Both foals had a positive fecal polymerase chain reaction, but shedding of the bacterium stopped <4 days after therapy was initiated. One foal was serologically positive 3 days after onset of clinical signs and remained positive for more than 6 months.
Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis (2004)

Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a member of the ATF/CREB family of transcription factors. However, the physiological significance of ATF3 induction by stress signals is not clear. In this report, we describe several lines of evidence supporting a role of ATF3 in stress-induced beta-cell apoptosis. First, ATF3 is induced in beta cells by signals relevant to beta-cell destruction: proinflammatory cytokines, nitric oxide, and high concentrations of glucose and palmitate. Second, induction of ATF3 is mediated in part by the NF-kappaB and Jun N-terminal kinase/stress-activated protein kinase signaling pathways, two stress-induced pathways implicated in both type 1 and type 2 diabetes. Third, transgenic mice expressing ATF3 in beta cells develop abnormal islets and defects secondary to beta-cell deficiency. Fourth, ATF3 knockout islets are partially protected from cytokine- or nitric oxide-induced apoptosis. Fifth, ATF3 is expressed in the islets of patients with type 1 or type 2 diabetes, and in the islets of nonobese diabetic mice that have developed insulitis or diabetes. Taken together, our results suggest ATF3 to be a novel regulator of stress-induced beta-cell apoptosis.
Stability, tissue metabolism, tissue distribution, and blood partition of DA-1131, a new carbapenem. (1995)

The stability of DA-1131 after incubation in various pH solutions, human plasma, human urine, human gastric juice, rat liver homogenates and rat whole blood, the disappearance of DA-1131 after incubation in the 9000g supernatant fraction of various rat tissue homogenates in the presence of NADPH, the tissue distribution of DA-1131 after intravenous (i.v.) administration of DA-1131, 50 mg/kg, to rats, and the blood partition of DA-1131 between plasma and blood cells from rabbit blood were studied. DA-1131 was unstable when incubated in various pH solutions, especially at low and high pHs at the DA-1131 concentration of 10 micro g/ml; the degradation half-lives of DA-1131 were 0.260, 1.23, 2.20, 7.16, 14.2, 10.5, 31.3, 21.3, 0.262, 0.241, and 1.45 hr for pH solutions of 1-11, respectively. DA-1131 was also unstable after incubation in human plasma, rat liver homogenates, and human gastric juice. However, DA-1131 seemed to be sable in human plasma for up to 12 hr storage at -20 degrees C. The spleen, kidney, liver, lung, mesentery, and stomach homogenates from rats showed metabolic activity to DA-1131. The tissue-to-plasma ratios of DA-1131 were lower than unity in all tissues studied except kidney when each tissue was collected at 30 min after i.v. administration of DA-1131 to rats. The tissue-to-plasma ratios of DA-1131 were lower than unity in all tissues studied except kidney when each tissue was collected at 30 min after i.v. administration of DA-1131 to rats. The plasma-to-blood cell concentration ratios of DA-1131 were independent of DA-1131 blood concentrations when the whole blood was incubated up to 120 min; the mean values were 5.56 +/- 1.47, 5.80 +/- 2.19, and 4.61 +/- 1.82 at DA-1131 blood concentrations of 2, 10, and 20 microgram/ml, respectively, rabbits A-C. There was also considerable in vivo and in vitro blood storage effect in the plasma concentration of DA-1131 in rabbits.
Olefin Oxidations with Excited Singlet Molecular Oxygen (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOlefin Oxidations with Excited Singlet Molecular OxygenChristopher S. Foote and S. WexlerCite this: J. Am. Chem. Soc. 1964, 86, 18, 3879–3880Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/ja01072a060https://doi.org/10.1021/ja01072a060research-articleACS PublicationsRequest reuse permissionsArticle Views1120Altmetric-Citations237LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Elastic-plastic analysis of rubber-toughened nylon by two-dimensional finite element method. (1990)

ゴム補強ナイロンの耐衝撃性を支配する構造因子がゴム粒子の壁間距離Lであることが最近Wuによって見いだされている. 本報では追試実験を行ってこのことを再確認するとともに, Lの物理的意味を考察すべく有限要素法 (FEM) を用いて弾塑性力学的応力解析を行った. FEM解析には, 円板状のゴムがナイロンマトリックスに内蔵されている平板状二相モデルを用いた. 各相はそれぞれ純成分ポリマーの真応力-真歪み曲線と同様の力学的応答を示し, Misesの降状条件が満たされたときに塑性変形すると仮定した. 変形とともに, ゴム粒子の赤道方向 (方位角θ=90°) のみならず極 (θ=0°) 及びθ=45°方向に応力集中が起こり, これらの方向に塑性変形領域が拡がっていくことがわかった. すなわち, ゴム粒子はその周辺のマトリックスを広い領域にわたって塑性変形させる役目を果していることがわかった. さらに隣接粒子の存在を併せ考えると, Lが短かいほど応力場の重なりや干渉が生じやすくなり, より一様なマトリックスの塑性変形が可能となるために衝撃強度が向上すると考えられる.
Unstable propagation of a Gaussian laser beam in a plasma waveguide (1976)

Laser heating of long magnetically confined plasma columns to fusion temperatures requires propagation of a trapped laser beam over considerable distances. The present paper employs the parabolic approximation to the wave equation to analyze the propagation of a Gaussian beam through a plasma with a parabolic transverse density profile. Although propagation is stable in the axially uniform case, exhibiting alternate focusing and defocusing of the beam, it is unstable to small axial perturbations of certain wavelengths. In particular, an exponentially growing beam radius results from perturbations at wavelengths near that associated with the alternate focusing and defocusing mentioned above.
JAVA Blueprint Procedure Pattern (2013)

Patterns can help us to use right experiences to solve a kind of questions of certain filed. They are summarized from software development, and then used to accelerate the design and development of software. This paper further discussed the program model of JAVA Blueprint and then summarized the special patterns of procedure blueprint. Firstly, this paper extended the definition of JAVA Blueprint. Then, it raised formalized definition framework of JAVA Blueprint and elaborated the three layers of view of Procedure Pattern. Finally, it illustrated to describe the Procedure Pattern. The raise of JAVA Blueprint Procedure Pattern provides convenient to program process modeling and advance the efficiency of software modeling, development and even maintenance.
Power Requirement and Energy Consumption of Bale Compression (2011)

Bales of corn stover, indiangrass, switchgrass, and wheat straw were compressed to determine their compression behavior in baled form. On average, the volume of all bales that were compressed was reduced by 67.4%. The baled crops follow a nonlinear density vs. pressure relationship that can be accurately predicted using an exponential equation. As loading speed increased, the energy, power, and specific energy required to compress the baled herbaceous biomass crops also increased. However, since each crop behaved differently during compression, the speed interaction was dependent on type of crop. To achieve a 60% reduction in bale volume at the slowest compression speed (2.54 mm/s), switchgrass required 15.6%, 61.7%, and 55.4% more energy than indiangrass, corn stover, and wheat straw, respectively. There were no significant differences in power or specific energy required at the slowest speed (a = 0.05). At the fastest compression speed (106.7 mm/s), switchgrass required 32.4%, 59.4%, and 73.0% more energy, 12.9%, 20.5%, and 27.0% more power, and 11.1%, 6.1%, and 19.3% more specific energy than indiangrass, corn stover, and wheat straw, respectively.
Metal ion-induced self-assembly of functionalized 2,6-oligopyridines. 1. Ligand design, synthesis, and characterization (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal ion-induced self-assembly of functionalized 2,6-oligopyridines. 1. Ligand design, synthesis, and characterizationKevin T. Potts, Kimberly A. Gheysen Raiford, and Majid Keshavarz-KCite this: J. Am. Chem. Soc. 1993, 115, 7, 2793–2807Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00060a029https://doi.org/10.1021/ja00060a029research-articleACS PublicationsRequest reuse permissionsArticle Views1057Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts