gebhart/patrepeval huggingface dataset:
Moisture Determination Using Karl Fischer Τitrations (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMoisture Determination Using Karl Fischer ΤitrationsSteven Κ. MacLeodCite this: Anal. Chem. 1991, 63, 10, 557A–566APublication Date (Print):May 15, 1991Publication History Published online30 May 2012Published inissue 15 May 1991https://pubs.acs.org/doi/10.1021/ac00010a720https://doi.org/10.1021/ac00010a720research-articleACS PublicationsRequest reuse permissionsArticle Views279Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electronic luminescence spectra of charge transfer states of titanium(IV) metallocenes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic luminescence spectra of charge transfer states of titanium(IV) metallocenesJohn W. Kenney III, David R. Boone, Durwin R. Striplin, Yong Hong Chen, and Kyle B. HamarCite this: Organometallics 1993, 12, 9, 3671–3676Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/om00033a045https://doi.org/10.1021/om00033a045research-articleACS PublicationsRequest reuse permissionsArticle Views466Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Different Shades of Oxide: From Nanoscale Wetting Mechanisms to Contact Printing of Gallium-Based Liquid Metals (2014)

Gallium-based liquid metals are of interest for a variety of applications including flexible electronics, soft robotics, and biomedical devices. Still, nano- to microscale device fabrication with these materials is challenging because, despite having surface tension 10 times higher than water, they strongly adhere to a majority of substrates. This unusually high adhesion is attributed to the formation of a thin oxide shell; however, its role in the adhesion process has not yet been established. In this work, we demonstrate that, dependent on dynamics of formation and resulting morphology of the liquid metal-substrate interface, GaInSn adhesion can occur in two modes. The first mode occurs when the oxide shell is not ruptured as it makes contact with the substrate. Because of the nanoscale topology of the oxide surface, this mode results in minimal adhesion between the liquid metal and most solids, regardless of substrate's surface energy or texture. In the second mode, the formation of the GaInSn-substrate interface involves rupturing of the original oxide skin and formation of a composite interface that includes contact between the substrate and pieces of old oxide, bare liquid metal, and new oxide. We demonstrate that in this latter mode GaInSn adhesion is dominated by the intimate contact between new oxide and substrate. We also show that by varying the pinned contact line length using varied degrees of surface texturing, the adhesion of GaInSn in this mode can be either decreased or increased. Lastly, we demonstrate how these two adhesion modes limit microcontact printing of GaInSn patterns but can be exploited to repeatedly print individual sub-200 nm liquid metal drops.
Medical Devices of the Abdomen and Pelvis (2005)

Medical devices in the abdomen and pelvis are probably less frequently seen than those in the chest or extremities, but they are important and should be recognized. These devices can be grouped into a few major categories: intestinal tubes, genitourinary devices, postoperative apparatus, and a wide variety of odds and ends. Many of these devices are used to monitor or treat gastrointestinal and genitourinary disease. Some of them, such as inferior vena cava filters and drug infusion pumps, treat systemic problems, and some of them are devices used in treating another anatomic region. It is strongly recommended that scout views for chest, abdominal, and pelvic computed tomographic studies be carefully examined for medical apparatus. Medical devices are often more easily recognized on scout images, and their inappropriate locations and complications can be better appreciated on the subsequent cross-sectional images if one is alerted to their presence in the first place. The evaluation of routine medical devices should be considered as important as any other aspect of a radiologic examination.
The use of mRNA differential display for discovery of novel therapeutic targets in cardiovascular disease (1997)

Recent advances in molecular biology techniques have provided powerful tools for discovery of novel genes relevant to both biological and pathological processes. mRNA differential display is an emerging technique for novel gene discovery and it has been successfully applied to many physiological and pathological conditions including normal development, cell differentiation, cancer, cardiovascular disease, inflammation and CNS disorders. In the present work, we briefly illustrate the critical procedure and highlight most recent technical improvements and modifications of this technology. Based upon the successful applications of this technique in cardiovascular research, it may provide a valuable and powerful investigational tool for the identification of novel therapeutic targets in cardiovascular diseases.
Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer (2018)

Treatment options for triple-negative breast cancer (TNBC) are limited due to the lack of efficient targeted therapies, frequently resulting in recurrence and metastatic disease. Accumulating evidence suggests that a small population of cancer stem-like cells (CSLCs) is responsible for tumor recurrence and therapy resistance. Here we investigated the role of cyclin-dependent kinase 9 (CDK9) in TNBC. Using The Cancer Genome Atlas (TCGA) data we found high-<i>CDK9</i> expression correlates with worse overall survival in TNBC patients. Pharmacologic inhibition of CDK9 with atuveciclib in high-<i>CDK9</i> expressing TNBC cell lines reduced expression of CDK9 targets <i>MYC</i> and <i>MCL1</i> and decreased cell proliferation and survival. Importantly, atuveciclib inhibited the growth of mammospheres and reduced the percentage of CD24<sup>low</sup>/CD44<sup>high</sup> cells, indicating disruption of breast CSLCs (BCSLCs). Furthermore, atuveciclib impaired 3D invasion of tumorspheres suggesting inhibition of both invasion and metastatic potential. Finally, atuveciclib enhanced the antineoplastic effects of Cisplatin and promoted inhibitory effects on BCSLCs grown as mammospheres. Together, these findings suggest CDK9 as a potential therapeutic target in aggressive forms of <i>CDK9</i>-high TNBC.
Measuring Bone Density Connectivity Using Dual Energy X-Ray Absorptiometry Images (2017)

Estimating bone density using mathematical models has direct applications in medical image processing. This paper presents a new measure for bone mineral density analysis based on the dual energy X-ray absorptiometry (DEXA) images. We are proposing an innovative procedure to calculate a scalar value that indicates the connectivity of bone mineral components from DEXA images. This method provides a totally novel measure for bone density study using DEXA scan images that can not only calculate T and Z values and can also determine the quality of the bone in terms of the average intensity of bone density. The new measure proposed is called the -measure and it provides new possibilities in terms of finding how well the bone components are connected. We can have T and Z corresponding to T and Z scores which augments the traditional values. Combining this method to a -connected maximum entropy concept, we obtain good segmentation results. The experiments results and data obtained shows that the new -measure should be in the range of [0.962, 0.977].
Synthesis and Properties of Benzophenone−Spiropyran and Naphthalene−Spiropyran Conjugates (2006)

We have designed and synthesized four compounds integrating luminescent and photochromic components in their molecular skeletons. Two of them combine a nitrospiropyran photochrome with either one or two naphthalene fluorophores and can be prepared in three synthetic steps. The other two consist of a nitrospiropyran photochrome and a benzophenone phosphore connected by either ether or ester linkages and can be prepared in six or five, respectively, synthetic steps. The luminescent components of these assemblies are expected to transfer energy intramolecularly to the photochromic species upon excitation and encourage their photoisomerization. Consistently, the phosphorescence of the benzophenone units and the fluorescence of the naphthalene components are effectively quenched when these species are connected covalently to a nitrospiropyran. Nonetheless, the photoisomerization of the photochrome becomes significantly less efficient after the covalent attachment to the luminescent partner. The fraction of incident radiations absorbed by either the benzophenone or the naphthalene fragment does not promote the isomerization of the photochromic appendage. Instead, irreversible transformations occur upon irradiation of the luminophore-photochrome assemblies. Thus, the covalent attachment of a benzophenone or a naphthalene to a nitrospiropyran is not a viable strategy to improve the photocoloration efficiency of the photochromic component. Even although the very same luminophores are known to sensitize intermolecularly the isomerization of nitrospiropyrans, the transition to covalent luminophore-photochrome assemblies tends to promote degradation, rather than sensitization, upon irradiation.
Preliminary studies towards the preparation of reactive 3-pyrrolin-2-ones in conjugate addition reactions for the syntheses of potentially bioactive 2-pyrrolidinones and pyrrolidines (2007)

Pyrrolin-2-ones and 2-pyrrolidinones are moieties often found in the structure of several biologically active natural products and 3-pyrrolin-2-ones are valuable starting materials in organic synthesis due to their ability to react as acceptors in conjugate addition reactions. In this article we report the initial results about the performed study aiming at the syntheses of reactive 3-pyrrolin-2-ones in conjugate addition reactions and the preparation of a potential precursor for the synthesis of the nootropic (+/-)-nebracetam.
Silylated Acid Hardened Resist [SAHR] Technology: Positive, Dry Developable Deep UV Resists (1990)

This paper describes continuing efforts in the development of Acid Hardened Resist (AHR) systems for use in deep UV photolithography. The Silylated AHR (SAHR) process treats a highly absorbing resist, such as XP-8928, with trimethylsilyldiethylamine. The exposed, crosslinked areas show virtually no reactivity with the silylating agent, and the unexposed areas incorporate 10 to 12% by weight silicon in the film. The silicon appears to incorporate from the exterior in a constant concentration, consistent with Case II diffusion. Subsequent dry etching leads to a positive tone image. The contrast is 5, and the photospeed is ~10 mJ/cm2. Resolution of 0.5 μm line/space pairs has been demonstrated, although substantial proximity effects are encountered.
[The diagnosis and treatment of atrophic bronchitis deformans]. (1996)

Ninety-seven patients were treated with laser radiation. A treatment course involved 5 to 7 exposures to radiation every second day. An exposure lasted 300 sec. As a result of treatment, cough completely ceased in 94 patients (96.9%). There was also a positive dynamics in the ultrastructural study of biopsy specimens taken prior to and following the therapy.
Phase I Combination Study of Trabectedin and Doxorubicin in Patients with Soft-Tissue Sarcoma (2008)

The combination of doxorubicin 60 mg/m(2) followed by trabectedin 1.1 mg/m(2) every 21 days is safe and active in patients with soft-tissue sarcoma.
Synthesis of Isoquinoline Alkaloids. II. The Synthesis and Reactions of 4-Methyl-3-pyridinecarboxaldehyde and Other 4-Methyl-3-substituted Pyridines<sup>1,2</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Isoquinoline Alkaloids. II. The Synthesis and Reactions of 4-Methyl-3-pyridinecarboxaldehyde and Other 4-Methyl-3-substituted Pyridines1,2J. M. BOBBITT and DANIEL A. SCOLACite this: J. Org. Chem. 1960, 25, 4, 560–564Publication Date (Print):April 1, 1960Publication History Published online1 May 2002Published inissue 1 April 1960https://pubs.acs.org/doi/10.1021/jo01074a018https://doi.org/10.1021/jo01074a018research-articleACS PublicationsRequest reuse permissionsArticle Views1042Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gonadotropins induce rapid phosphorylation of the 3',5'-cyclic adenosine monophosphate response element binding protein in ovarian granulosa cells. (1996)

The pituitary gonadotropins FSH and LH exert their effects on gonadal target cells, at least in part, through the activation of adenylyl cyclase and the production of the second messenger cAMP. To elucidate further the signal transduction pathways regulating gonadotropin-responsive genes in ovarian granulosa cells, we have investigated the expression of the cAMP response element binding protein (CREB), which mediates many of the effects of cAMP by modulating the transcription of target genes in a cAMP-dependent fashion. In situ hybridization, RNA blot analysis and RT-PCR RNA quantification demonstrated that CREB messenger RNA (mRNA) is expressed at low levels throughout the ovary, and that CREB mRNA levels do not change appreciably after gonadotropin stimulation. Similar results were obtained using immunohistochemistry and Western protein blotting to examine CREB protein in ovaries isolated from immature animals treated with gonadotropins or immunocytochemistry and Western protein blotting to examine the CREB protein in cultured granulosa cells after gonadotropin treatment. In contrast, immunocytochemistry and Western protein blotting using an antipeptide antibody specific to CREB phosphorylated at serine 133 (P-CREB), which is the activated from of the CREB protein, revealed a dramatic increase in the phosphorylated form of CREB within 20 min of gonadotropin treatment of granulosa cells that was transient and was decreased by 60 min after gonadotropin treatment. Stimulation of P-CREB was observed using granulosa cells isolated from immature animals and treated with recombinant human FSH in vitro, or using granulosa cells isolated from immature animals primed with PMSG in vivo and treated with human CG (hCG) in vitro. Stimulation of P-CREB was also observed in ovarian granulosa cells isolated from animals treated with PMSG in vivo. These results indicate that both gonadotropins can induce a rapid and transient phosphorylation of the CREB protein in granulosa cells, leading to the activation of a factor likely to play an important role in the transcription of many gonadotropin-regulated ovarian genes.
A cure for HIV: is it in sight? (2014)

HIV is a devastating disease affecting millions of people worldwide despite the advent of successful antiretroviral therapy (ART). However, ART does not result in a cure and has to be taken for life. Accordingly, researchers are turning towards cure efforts, particularly in the light of two patients whose HIV has been seemingly eradicated. Numerous approaches and strategies have been considered for curing HIV, but no scalable and safe solution has yet been reached. With newly discovered difficulties in measuring the HIV reservoir, the main barrier to a cure, the only true test of cure is to stop ART and see whether the virus becomes detectable. However, it is possible that this treatment interruption may be associated with certain risks for patients. Here, we compare the current major approaches and recent advances for curing HIV, as well as discuss ways of evaluating HIV cure and the safety concerns involved.
Leveraging microarchitectural side channel information to efficiently enhance program control flow integrity (2014)

Stack buffer overflow is a serious security threat to program execution. A malicious attacker may overwrite the return address of a procedure to alter its control flow and hence change its functionality. While a number of hardware and/or software based protection schemes have been developed, these countermeasures introduce sizable overhead in performance and energy, thus limiting their applicability to embedded systems. To reduce such overhead, our goal is to develop a low-cost scheme to "filter out" potential stack buffer overflow attacks. Our observation is that attacks to control flow will trigger certain microarchitectural events, such as mis-predictions in the return address stack or misses in the instruction cache. We therefore propose a hardware-based scheme to monitor these events. Only upon detecting any suspicious behavior, a more precise but costly diagnosis scheme will be invoked to thoroughly check control flow integrity. Meanwhile, to further reduce the rate of false positives of the security filter, we propose three enhancements to the return address stack, instruction prefetch engine and instruction cache, respectively. The results show that these enhancements effectively reduce more than 95% of false positives with almost no false negatives introduced.
A New Approach in the Use of Gradients for Size-Resolved 2D-NMR Experiments (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New Approach in the Use of Gradients for Size-Resolved 2D-NMR ExperimentsNicolas Birlirakis and Eric GuittetView Author Information Laboratoire de RMN, Institut de Chimie des Substances Naturelles, CNRS 1 Avenue de la Terrasse, F-91198 Gif sur Yvette, France Cite this: J. Am. Chem. Soc. 1996, 118, 51, 13083–13084Publication Date (Web):December 25, 1996Publication History Received5 August 1996Published online25 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja9627151https://doi.org/10.1021/ja9627151rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views291Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Diffusion,Magnetic properties,Mixtures,Phase transitions,Transport properties Get e-Alerts
An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma (2008)

Our data support the idea that intronic miRNAs and their host genes are regulated dependently, and may contribute to the understanding of their biological roles in cancer. To our knowledge, this is the first evidence of deregulated miRNA expression in MM, providing insights that may lead to the identification of new biomarkers and altered molecular pathways of the disease.