gebhart/patrepeval huggingface dataset:
Thymopoietin Enhances the Allogeneic Response and Cyclic GMP Levels of Mouse Peripheral, Thymus-Derived Lymphocytes (1978)

The action of the purified thymic factor, thymopoietin, on populations of post-thymic lymphocytes has been studied. Thymopoietin, at concentrations as low as 1.5 ng/ml, uniquely enhanced the proliferative response of peripheral T cells from lymph node and spleen to allogeneic stimulation. Enhancement of the allogeneic response (MLR) was not produced by several polypeptide hormones, including insulin, ACTH, HCG, or Ubiquitin. Treatment of spleen cells with anti-Thy-1 antiserum almost completely abolished the MLR. Thymopoietin's stimulatory effects could not reverse this. Thymopoietin treatment of Thy-1+-enriched spleen cell populations enhanced the MLR even when thymopoietin was removed as early as 2 min after incubation with responding cells. The interaction of thymopoietin with peripheral Thy-1+ cell populations produced a rapid and transient rise in cyclic GMP levels and slightly decreased cyclic AMP levels. These results suggest that thymopoietin interacts with one or more Thy-1+ subpopulations and that this interaction involves early changes in cyclic nucleotide metabolism.
Chemical and electrochemical copolymerization of aniline with alkyl ring-substituted anilines (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical and electrochemical copolymerization of aniline with alkyl ring-substituted anilinesYen Wei, Ramakrishnan Hariharan, and Sandeep A. PatelCite this: Macromolecules 1990, 23, 3, 758–764Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ma00205a011https://doi.org/10.1021/ma00205a011research-articleACS PublicationsRequest reuse permissionsArticle Views1001Altmetric-Citations245LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chiral metal architectures in aminopyridinato complexes of zirconium (2004)

Optically pure 2-alkylaminopyridines (HL) are synthesised readily from bromopyridines and chiral amines [(S)-1,2,3,4-tetrahydro-1-naphthylamine and (S)-(-)-alpha-methylbenzylamine] using palladium-catalysed amination. Protonolysis reactions of these proligands with ZrX(4)(X = NMe(2), CH(2)Ph, CH(2)Bu(t)) yield zirconium aminopyridinates, usually of the type [ML(2)X(2)], some of which have been characterised by X-ray crystallography. Control of absolute configuration at the metal centre is pursued by investigation of the effects of chiral amine substituent, substitution at the pyridine rings and the identity of co-ligands. Surprisingly the conformationally flexible [small alpha]-methylbenzyl based aminopyridinato ligands promote much better control of chirality-at-zirconium than do the cyclic tetrahydronaphthyl analogues. One complex of the former class displays complete control of stereochemistry at 193 K; only one diastereomer out of eight possible structures is observed. It is found that there is an excellent correlation between observed selectivities and calculated diastereomer energy differences from DFT. All the complexes studied are in dynamic exchange between diastereomers. The rate of these processes (DeltaH ca. 40 kJ mol(-1)) as studied by Selective Polarisation Transfer-Selective Inversion Recovery experiments (SPT-SIR) and lineshape analyses are significantly faster than those for aminopyridines containing bulkier amido substituents (DeltaH ca. 70 kJ mol(-1)). This type of dependence on steric effects, and the impact of the trans effect, is consistent with an N-dissociative mechanism, i.e. conversion from six- to five-coordinate structure followed by rapid intramolecular scrambling.
Effects of perillyl alcohol on melanoma in the TPras mouse model. (2002)

This study evaluates the chemopreventive effects of topically applied perillyl alcohol on the development of melanoma in TPras transgenic mice. Our strategy was to target critical pathways in the development of melanoma, in particular, the ras pathway. Ras has been shown in our experimental mouse model, as well as others, to be important in the development and maintenance of melanomas. Perillyl alcohol (POH), a naturally occurring monoterpene, inhibits the isoprenylation of small G protein, including Ras. POH (10 mM) was applied to the shaved dorsal skin of TPras mice starting 1 week before five treatments of dimethylbenz[a]anthracene (50 microg) and was continued for 38 weeks. We observed a delay in the appearance of tumors and a 25-35% reduction in melanoma incidence. POH treatment of melanoma cells in vitro reduced the levels of detectable Ras protein and inhibits the activation of downstream targets, mitogen-activated protein kinases and Akt. POH only minimally induced apoptosis in this system. Pretreatment but not post-treatment of the melanoma cells with POH, however, markedly reduced levels of UV-induced reactive oxygen species. These studies suggest that POH inhibition of the Ras signaling pathway may be an effective target for chemoprevention of melanoma.
Reversibility of IVS 2 missplicing in a mutant human beta-globin gene. (1985)

We have studied the aberrant splicing of a human beta thalassemia globin gene by expression of the cloned gene in HeLa cells and oligomer-directed mutagenesis. A mutation 705 nucleotides into the large intervening sequence (IVS 2) of this gene leads to missplicing in which IVS 2 is incompletely removed, via two aberrant splices, from the vast majority of transcripts. One splice is from the 5' end of IVS 2 to a normal sequence 580 nucleotides into IVS 2 and another is from the mutated site 705 nucleotides into IVS 2 to the 3' end of the IVS. To study the splicing of this gene further, a mutation was introduced into the cryptic 3' splice site at position 580. This results in the complete removal of IVS 2 despite the presence of the thalassemia mutation at 705. The reversal of abnormal splicing by a change in the cryptic splice site suggests that the two abnormal splices are subtly interdependent. Thus, single base changes within IVS 2 can drastically alter the pattern of splicing in a human beta-globin gene.
Psoralen photochemical inactivation of <i>Orientia tsutsugamushi</i> in platelet concentrates (2000)

The psoralen AMT, in conjunction with UVA light exposure, effectively abolished the infectivity of PCs deliberately contaminated with the scrub typhus organism O. tsutsugamushi, as tested in a mouse infectivity assay.
Aerosol direct fluorination. Indirect syntheses of perfluoro cyclic ketones (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAerosol direct fluorination. Indirect syntheses of perfluoro cyclic ketonesJames L. Adcock and Mark L. RobinCite this: J. Org. Chem. 1984, 49, 1, 191–193Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/jo00175a047https://doi.org/10.1021/jo00175a047research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Stochastic Geometry for Modeling, Analysis, and Design of Multi-Tier and Cognitive Cellular Wireless Networks: A Survey (2013)

For more than three decades, stochastic geometry has been used to model large-scale ad hoc wireless networks, and it has succeeded to develop tractable models to characterize and better understand the performance of these networks. Recently, stochastic geometry models have been shown to provide tractable yet accurate performance bounds for multi-tier and cognitive cellular wireless networks. Given the need for interference characterization in multi-tier cellular networks, stochastic geometry models provide high potential to simplify their modeling and provide insights into their design. Hence, a new research area dealing with the modeling and analysis of multi-tier and cognitive cellular wireless networks is increasingly attracting the attention of the research community. In this article, we present a comprehensive survey on the literature related to stochastic geometry models for single-tier as well as multi-tier and cognitive cellular wireless networks. A taxonomy based on the target network model, the point process used, and the performance evaluation technique is also presented. To conclude, we discuss the open research challenges and future research directions.
An Efficient Re-quantization Error Compensation for MPEG2 to H.264 Transcoding (2006)

During transcoding, the coefficients have to pass through another quantization step. This introduces re-quantization errors to the coefficients. H.264 integer transform and quantization features are different from those of MPEG2 and other standards. Based on these features, in MPEG2 to H.264 transcoding, an efficient algorithm that measures the re-quantization error is proposed. Then this measured error is used to compensate for the quality loss in transcoding. The experimental results from four typical video test sequences show that the proposed compensation procedure improves the PSNR value by about 4.82 dB. The error calculation and compensation could be carried in the transform domain resulting in significant computational saving
Small-Molecule, Nonfullerene Acceptors for Polymer Bulk Heterojunction Organic Photovoltaics (2010)

In the field of polymer bulk-heterojunction organic photovoltaics, fullerenes and fullerene derivatives clearly play the dominant role as acceptor materials. Recently, a number of research efforts have focused on the development of new small-molecule acceptors for this device configuration. Although few materials prepared to-date have demonstrated power conversion efficiencies close to those achieved with fullerenes, numerous design rules and some interesting new materials classes have been explored. This short review will highlight the progress toward higher efficiency in nonfullerene small-molecule acceptors for organic solar cells.
Nickel-induced crystallization of amorphous silicon (2009)

One- and two-dimensional silicon nanostructures, such as nanodots, nanowires, and surface topography, have potential uses in a variety of fields, including microelectronics, photonics, and tribology. In this thesis research, nickel-induced crystallization (NIC) of amorphous silicon (a-Si) was investigated to determine the suitability of NIC of a-Si to produce silicon nanostructures on silicon substrates. The results show that formation of both surface topography and nanowires is possible with NIC of a-Si. In addition, the formation of nanostructures is very sensitive to Ni thickness, and the resulting nanostructures and films display a high degree of repeatability. The results obtained from this research provide a solid foundation for future studies in NIC of a-Si.
Fast division algorithm with a small lookup table (2003)

This paper presents a new division algorithm, which requires two multiplication operations and a single lookup in a small table. The division algorithm takes two steps. The table lookup and the first multiplication are processed concurrently in the first step, and the second multiplication is executed in the next step. This divider uses a single multiplier and a lookup table with 2/sup m/(2m+1) bits to produce 2 m-bit results that are guaranteed correct to one ulp. By using a multiplier and a 12.5 KB lookup table, the basic algorithm generates a 24-bit result in two cycles.
Generalized methods and solvers for noise removal from piecewise constant signals. I. Background theory (2011)

Removing noise from piecewise constant (PWC) signals is a challenging signal processing problem arising in many practical contexts. For example, in exploration geosciences, noisy drill hole records need to be separated into stratigraphic zones, and in biophysics, jumps between molecular dwell states have to be extracted from noisy fluorescence microscopy signals. Many PWC denoising methods exist, including total variation regularization, mean shift clustering, stepwise jump placement, running medians, convex clustering shrinkage and bilateral filtering; conventional linear signal processing methods are fundamentally unsuited. This paper (part I, the first of two) shows that most of these methods are associated with a special case of a generalized functional, minimized to achieve PWC denoising. The minimizer can be obtained by diverse solver algorithms, including stepwise jump placement, convex programming, finite differences, iterated running medians, least angle regression, regularization path following and coordinate descent. In the second paper, part II, we introduce novel PWC denoising methods, and comparisons between these methods performed on synthetic and real signals, showing that the new understanding of the problem gained in part I leads to new methods that have a useful role to play.
The galactosyl-(alpha 1-4)-galactose-binding adhesin of Streptococcus suis: occurrence in strains of different hemagglutination activities and induction of opsonic antibodies (1996)

The occurrence of the galactose-(alpha 1-4)-galactose-specific adhesin in Streptococcus suis, a pig and human pathogen causing sepsis, meningitis, and other serious infections, was studied. Poly- and monoclonal anti-bodies to the purified adhesin, as well as pigeon ovomucoid, a specific probe for the adhesin activity, detected one single protein band in extracts of S. suis. The adhesin was detected in all 23 strains studied, representing pathogenic serotypes (1, 2, 4, 5, 7, 8, and nontypeable) and including several weakly hemagglutinating or nonhemagglutinating strains and phase variants. The amount of adhesin detected was not correlated with the hemagglutination activity of the intact bacteria. Extraction of cells showing no binding of pigeon ovomucoid by ultrasonic treatment resulted in extracts with pigeon ovomucoid binding activity, suggesting that the adhesin was not accessible to the probe on the intact cells. Analysis of the amount of capsular polysaccharide revealed an inverse relationship between the hemagglutination activity and expression of capsular polysaccharide, thus suggesting a factor influencing adhesin accessibility. The purified adhesin was highly immunogenic and induced in preliminary experiments bactericidal activity in mice. Thus, the adhesin, with its specific binding mechanism to host cells and a proposed pathogenic role, is widely expressed among strains of different serotypes and therefore appears to represent a novel promising candidate for the development of a vaccine against S. suis.
Short‐term variability of systolic blood pressure and heart rate in normotensive subjects (1990)

Short-term fluctuations in systolic blood pressure (SBP) and heart rate (HR) and their inter-relationship were analysed in a group of normotensive middle-aged men (n = 16) using a multivariate autoregressive modelling technique. This study is the first to evaluate the beat-to-beat variability of SBP and HR in a group of real normotensive subjects. Direct intra-arterial blood pressure was registered together with ECG using an ambulatory tape recording technique (the Oxford method). Power spectrum density estimated (PSD) were used as a measure of the variability. PSDs were calculated over 3-min periods for four basic physiological conditions: during sleep and in the supine, sitting and standing positions. The inter-relationship between the blood pressure and heart rate variabilities was analysed using a closed-loop model. In agreement with results presented earlier in the literature, the beat-to-beat variation in SBP and HR was concentrated in three typical power spectrum regions: the high-frequency (HF = 0.15-0.35 Hz) region (respiration), the mid-frequency (MF = 0.075-0.15 Hz) region (vasomotor oscillation) and the low-frequency (LF = 0.02-0.075 Hz) region (thermoregulation). The variability changes considerably between different situations, especially that of the MF region. The variability was most prominent in the MF region and in the standing position. The variability was generally smallest in the HF region and in sleep. The results also demonstrate that the beat-to-beat variability in SBP and HR can considerably affect one another.
Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial (2011)

PTX improved histological features of NASH compared to placebo. PTX was well tolerated in patients with NASH.
Role of Neutrophil Extracellular Traps in Asthma and Chronic Obstructive Pulmonary Disease (2017)

Excessive NETs accumulate in the airways of asthmatics and COPD patients. Although NETs play an essential role in the innate immune system against infection, excessive components of NETs can cause lung tissue damage and accelerate disease progression in asthmatics and COPD patients. These findings suggest that administration of NETs could be a novel approach to treat asthma and COPD. Mechanism studies, clinical practice, and strategies to regulate neutrophil activation or directly interrupt NET function in asthmatics and COPD patients are desperately needed.
Optimal straightening vanes for turbine meters (1995)

The sensitivity of turbine flow meters to a set of disturbed velocity profiles can be used to give an indication of the errors that may occur in practical circumstances as a result of installation conditions. The International Standard ISO 9951 defines a set of perturbations that are suitable for this purpose. The Standard requires the manufacturer to specify the installation conditions, such as straight lengths, straighteners, etc. so that the change in error due to the standard perturbations is less than one third of the maximum error allowed for undisturbed flow. Using these straighteners, systematic experiments were carried out with vane type straighteners in the annular duct leading up to the turbine meter rotor and also for round holes in a plate preceding the meter module. It showed that for a particular length of the vanes or thickness of the plate, the swirl was virtually eliminated. A combination of such optimally designed vanes was incorporated in a meter. In addition, the design was made to cause intense radial exchange of momentum.
A game theoretic framework for bandwidth allocation and pricing in broadband networks (2000)

In this paper, we present a game theoretic framework for bandwidth allocation for elastic services in high-speed networks. The framework is based on the idea of the Nash bargaining solution from cooperative game theory, which not only provides the rate settings of users that are Pareto optimal from the point of view of the whole system, but are also consistent with the fairness axioms of game theory. We first consider the centralized problem and then show that this procedure can be decentralized so that greedy optimization by users yields the system optimal bandwidth allocations. We propose a distributed algorithm for implementing the optimal and fair bandwidth allocation and provide conditions for its convergence. The paper concludes with the pricing of elastic connections based on users' bandwidth requirements and users' budget. We show that the above bargaining framework can be used to characterize a rate allocation and a pricing policy which takes into account users' budget in a fair way and such that the total network revenue is maximized.
DC traction power system grounding (2002)

The paper provides a review of the present practice of DC traction power system grounding methods employed in North America. An analysis of equipment grounding, system grounding and their relationships to achieve optimized equipment and personal safety is derived. Generic protective relay schemes commonly used in the DC equipment enclosure grounding are shown. Rail leakage stray current and personnel safety affected by the DC system grounding method are discussed. To enhance personnel/equipment safety, specific recommendations for the design of the DC traction power system grounding are included.
Purification and characterization of enterocin 4, a bacteriocin produced by Enterococcus faecalis INIA 4 (1996)

A simple two-step procedure was developed to obtain pure enterocin 4, a bacteriocin produced by Enterococcus faecalis INIA 4. Chemical and genetic characterization revealed that the primary structure of enterocin 4 is identical to that of peptide antibiotic AS-48 from Enterococcus faecalis S-48. In contrast to the reported inhibitory spectrum of AS-48, enterocin 4 displayed no activity against gram-negative bacteria.
Flexible processing framework for online event data and software triggering (2000)

The BABAR experiment is the particle detector at the new PEP-II "B factory" facility at the Stanford Linear Accelerator Center. The experiment's goal is the detailed study of the fundamental phenomenon of charge-parity symmetry breaking in B meson decays. Within the detector's online system, the Online Event Processing subsystem (OEP) provides for near real-time processing of data delivered from the data acquisition system's event builder. It supports four principal tasks: the final "Level 3" software trigger, rapid-feedback fast data quality monitoring, event displays, and the final steps in online calibrations. In order to accommodate the expected 2000 Hz event rate, the OEP subsystem runs on computing farm, receiving events on each node into a shared memory buffer system and coordinating processes performing analysis on this data. Analysis tasks are assigned administrative characteristics providing for protection of data integrity and ensuring that indispensable tasks such as triggering are always performed, while others are performed as resources are available. Data access in OEP uses BABAR's standard offline reconstruction framework. Thus, notably, the Level 3 trigger software could be developed in advance in the full offline simulation environment and yet be suitable for near-real-time online running with minimal changes.