gebhart/patrepeval huggingface dataset:
Adult and fetal human mesangial cells interact with specific laminin domains (1991)

Mesangial cells are centrally located pericytes in the renal glomerulus. They are surrounded by an extracellular matrix and directly contact the glomerular basement membrane in vivo. Because these interactions are critical for renal development and function, we have studied human mesangial cell interactions with laminin, a major adhesive component of basement membranes present in the extracellular matrix of the mesangium. Human fetal and adult mesangial cell attachment was stimulated by both laminin and the laminin-derived synthetic peptides YIGSR-NH2, CQAGTFALRGDNPQG-NH2, and CIKVAVS-NH2. Furthermore, mesangial cells spread on laminin as well as on both the RGD-containing and CIKVAVS peptides. When added in solution, all three peptides inhibited mesangial cell attachment to laminin, and the latter two peptides inhibited mesangial cell spreading on laminin. Laminin affinity column chromatography demonstrated several low-molecular-mass laminin-binding proteins ranging from between 35 and 42 kDa, which predominated in fetal mesangial cells, whereas a higher molecular mass laminin-binding protein of 65 kDa was predominant in adult mesangial cells. Western blot analysis with an anti-32-kDa laminin-binding protein antibody showed increased expression of both 31- and 42-kDa proteins in fetal mesangial cells when compared with the adult. The antisera to the 32-kDa laminin-binding protein also inhibited fetal mesangial spreading on the CIKVAVS peptide. Western blot analysis with an anti-67-kDa laminin-binding protein antibody revealed a 110-kDa protein in adult mesangial cells that was not present in fetal mesangial cells.(ABSTRACT TRUNCATED AT 250 WORDS)
A Design of a Control Method for Changing Yaw Direction of an Underacuatted Unicycle Robot (2006)

We have developed a unicycle robot that consists of a body, a disk driven by a DC motor for rotation, and a wheel driven by another DC motor to move the body. Since there is no direct force for changing the yaw direction of the robot, conventional controllers cannot change the yaw direction. The present paper proposes a control method for changing the yaw direction by using the interaction between individual motions in the yaw, pitch, and roll directions. Simulation results show the performances of the proposed controller. 1) The proposed control method is useful for a regulator problem and can control the yaw direction of the unicycle robot toward zero from any initial value. 2) The controller can cancel a disturbance applied to the robot motion
The Use of Global and Mesoscale Meteorological Model Data to Predict the Transport and Dispersion of Tracer Plumes over Washington, D.C. (2006)

Abstract The data from a yearlong tracer dispersion experiment over Washington, D.C., in 1984 were used to evaluate Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) dispersion model calculations using coarse global meteorological reanalysis data [NCEP–NCAR and 40-Yr ECMWF Re-Analysis (ERA-40)] and calculations using meteorological data fields created by running a high-resolution meteorological model [fifth-generation Pennsylvania State University–NCAR Mesoscale Model (MM5)]. None of the meteorological models were optimized for urban environments. The dispersion calculation using the ERA-40 data showed better performance than those using the NCEP–NCAR data and comparable performance to those using MM5 data fields. Calculations with MM5 data that used shorter-period forecasts were superior to calculations that used forecast data that extended beyond 24 h. Daytime dispersion model calculations using the MM5 data showed an underprediction bias not evident in calculations using the ERA-40 data or for nighttime calculations using either meteorological dataset. It was found that small changes in the wind direction for all meteorological model data resulted in dramatic improvements in dispersion model performance. All meteorological data modeled plume directions were biased 10°–20° clockwise to the measured plume direction. This bias was greatest when using the global meteorological data. A detailed analysis of the wind observations during the November intensive, which had the greatest difference between the model and measured plume directions, showed that only the very lowest level of observed winds could account for the transport direction of the measured plume. In the Northern Hemisphere, winds tend to turn clockwise with height resulting in positive directional transport bias if the lowest-level winds are not represented in sufficient detail by the meteorological model.
A universal large/small signal 3-terminal FET model using a nonquasistatic charge-based approach (1993)

Introduces a charge-based nonquasistatic large/small signal FET model that is extracted from measured small signal S-parameter and DC data and can be applied to an arbitrary three-terminal FET structure. The model is based on general physical principles, and provides consistent topologies for both large and small signal simulations to frequencies above f/sub t/ and over a wide range of node voltages. The procedure for extracting model elements includes deembedding linear parasitic elements and extracting bicubic, B-spline functions, which represent large signal model elements. The spline coefficients are calculated using a constrained least squares fit to a set of small signal parameters and/or DC currents that have been measured at a number of node voltage values. Advantages of this approach include fast parameter extraction for new FET structures, accuracy, computational efficiency, charge conservation, and the requirement of only a single model for all simulation modes. The model can also be used to interface device simulators (e.g., PISCES) with circuit simulators for accurate predictive modeling.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nonvolatile Memory With a Metal Nanocrystal/Nitride Heterogeneous Floating-Gate (2005)

Heterogeneous floating-gates consisting of metal nanocrystals and silicon nitride (Si/sub 3/N/sub 4/) for nonvolatile memory applications have been fabricated and characterized. By combining the self-assembled Au nanocrystals and plasma-enhanced chemical vapor deposition (PECVD) nitride layer, the heterogeneous-stack devices can achieve enhanced retention, endurance, and low-voltage program/erase characteristics over single-layer nanocrystals or nitride floating-gate memories. The metal nanocrystals at the lower stack enable the direct tunneling mechanism during program/erase to achieve low-voltage operation and good endurance, while the nitride layer at the upper stack works as an additional charge trap layer to enlarge the memory window and significantly improve the retention time. The write/erase time of the heterogeneous stack is almost the same as that of the single-layer metal nanocrystals. In addition, we could further enhance the memory window by stacking more nanocrystal/nitride heterogeneous layers, as long as the effective oxide thickness from the control gate is still within reasonable ranges to control the short channel effects.
INDOOR AIR QUALITY AND ENERGY CONSERVATION EFFECT OF NATURAL VENTILATION ON OFFICE BUILDINGS (2012)

In this study, considering the outdoor air quality when natural ventilation estimated that high concentrations due to the closure of the opening, that aims to determine the impact on the reduction of cooling load.We calculate the airflow and contaminant concentration distribution with CFD analysis in the three models, the results are reflected, thermal and airflow network analysis was performed by annual meteorological data.One result of analysis that openings were restricted to prevent the flow of outdoor pollutants, total natural ventilation time was about 50% shorter. And the cooling load was decreased by 10%.
FR: A Novel Strategy to Improve Item-Oriented Collaborative Filtering (2011)

Traditional Item-oriented Collaborative Filtering (ICF) suffers the problem of low recommendation accuracy in spite of its popularity. In this paper we propose two novel strategies respectively named Recommendation Bias Removal (RBR) and Folksonomy Network Based Filtering (FNBF) to address this issue; with a special focus on the accuracy of individual recommendations. RBR statistically estimates the Recommendation Bias (RB) between system predictions and actual user ratings, and then modifies the system predictions via removing the corresponding RB estimations. FNBF first builds the Folksonomy Network (FN) model based on the folksonomy data, and then applies the FN model to filtering out the irrelative recommendation results of ICF. We further combine FNBF and RBR to form the FR strategy which can further improve the recommendation quality based on information from both ratings and folksonomy data. The empirical studies on large real datasets showed that both FNBF and RBR were effective on the accuracy issue; furthermore, a recommender with FR could make more accurate recommendations due to the aggregating effect of FNBF and RBR.
Preparing of CIGS Nanoparticles Using One Step Synthesis (2010)

Abstract not Available.
Reconstructing scenes with mirror and glass surfaces (2018)

Planar reflective surfaces such as glass and mirrors are notoriously hard to reconstruct for most current 3D scanning techniques. When treated naïvely, they introduce duplicate scene structures, effectively destroying the reconstruction altogether. Our key insight is that an easy to identify structure attached to the scanner---in our case an AprilTag---can yield reliable information about the existence and the geometry of glass and mirror surfaces in a scene. We introduce a fully automatic pipeline that allows us to reconstruct the geometry and extent of planar glass and mirror surfaces while being able to distinguish between the two. Furthermore, our system can automatically segment observations of multiple reflective surfaces in a scene based on their estimated planes and locations. In the proposed setup, minimal additional hardware is needed to create high-quality results. We demonstrate this using reconstructions of several scenes with a variety of real mirrors and glass.
Specific Inhibition of Influenza Virus RNA Polymerase and Nucleoprotein Gene Expression by Liposomally Encapsulated Antisense Phosphorothioate Oligonucleotides in MDCK Cells (1998)

We have demonstrated that antisense phosphorothioate oligonucleotides (S-ODNs) inhibit influenza A virus replication in MDCK cells. Liposomally encapsulated and free antisense S-ODNs with four target sites (PB1, PB2, PA and NP genes) were tested for their abilities to inhibit virus-induced cytopathogenic effects in a MTT assay using MDCK cells. The liposomally encapsulated S-ODN complementary to the site around the PB2 AUG initiation codon showed highly inhibitory effects. In contrast, the inhibitory effect of the liposomally encapsulated S-ODN targeted to PB1 was considerably decreased in comparison with that directed to the PB2 target site. The liposomally encapsulated antisense S-ODNs exhibited higher inhibitory activities than the free oligonucleotides, and showed sequence-specific inhibition, whereas free antisense S-ODNs were observed to inhibit viral adsorption to MDCK cells. Liposomal preparations of oligonucleotides facilitated their release from endocytic vesicles, and thus cytoplasmic and nuclear localization was observed. The activities of the antisense S-ODNs were effectively enhanced by using the liposomal carrier. Interestingly, the liposomally encapsulated FITC-S-ODN-PB2-as accumulated in the nuclear region of MDCK cells. However, weak fluorescence was observed within the endosomes and the cytoplasm of MDCK cells treated with the free antisense S-ODNs. The cationic lipid particles may thus be a potentially useful delivery vehicle for oligonucleotide-based therapeutics and transgenes, appropriate for use in vitro or in vivo.
Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis (1998)

PWA is a simple and reproducible technique with which to measure PWV and AIx. Reproducibility accords with that reported by other workers using different methodologies. PWA may, therefore, be suitable for large-scale population and intervention studies investigating the clinical relevance of vascular stiffness.
A/B behaviour pattern not correlated with other coronary risk factors in industrial plant populations. (1982)

The behaviour pattern was assessed in two groups of middle aged men, 157 subjects selected randomly from a coronary risk group of 1553 subjects and 83 respondents for physical fitness testing. The number of risk factors i.e. smoking, hypertension, hypercholesterolemia, angina pectoris by chest-pain questionnaire and positive family history was higher in the physical fitness testing respondents than in randomly selected subjects, the difference being highest for A Type men. No correlation between the behaviour pattern and prevalence of RF was found. Subjects with higher score of neuroticism in EPI were the heaviest smokers.
Expression of epidermal growth factor (EGF)/transforming growth factor-α by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice (2007)

Epidermal growth factor receptor (EGFR) has been extensively targeted in the treatment of non-small cell lung cancer, producing responses in a small number of patients. To study the role of ligand expression in mediating response to EGFR antagonism, we injected NCI-H441 [EGFR and EGF/transforming growth factor-alpha (TGF-alpha) positive] or PC14-PE6 (EGFR positive and EGF/TGF-alpha negative) human lung adenocarcinoma cells into the lungs of nude mice. We randomized the mice to receive treatment with the EGFR tyrosine kinase inhibitors gefitinib or AEE788 or vehicle. Treatment of mice bearing NCI-H441 but not PC14-PE6 lung tumors resulted in a significant reduction in primary tumor growth, pleural effusion, and lymph node metastasis. Immunohistochemical analyses revealed that NCI-H441 and PC14-PE6 cells expressed EGFR but that the expression of EGF/TGF-alpha was high in NCI-H441 cells and very low in PC14-PE6 cells. Consequently, EGFR was activated in both tumor and tumor-associated endothelial cells in the NCI-H441 tumors but not in the PC14-PE6 tumors. Antagonism of EGFR signaling by treatment of mice with AEE788 decreased proliferation and increased apoptosis of both tumor cells and tumor-associated endothelial cells in NCI-H441 tumors but not in PC14-PE6 tumors. However, after transfection of PC14-PE6 cells with TGF-alpha, lung tumors derived from the transfected cells expressed and activated EGFR in both tumor and tumor-associated endothelial cells and tumors responded to treatment with AEE788. Collectively, these results strongly suggest that the response of human lung cancers growing orthotopically in mice to the inhibition of EGFR signaling is determined by ligand (EGF/TGF-alpha) expression by tumor cells. Our findings provide an additional explanation for the susceptibility of lung cancers to treatment with EGFR tyrosine kinase inhibitors.
Naturally Occurring Antihormones: Secretion of FSH Antagonists by Women Treated with a GnRH Analog (1988)

Follicle-stimulating hormone (FSH) is a glycoprotein essential for gonadal development and steroidogenesis. Recent studies suggest that deglycosylation of FSH results in the formation of antagonistic proteins that are capable of binding to gonadal receptors but that are devoid of bioactivity. Treatment of hypogonadal women with an antagonist of gonadotropin-releasing hormone substantially decreased serum FSH bioactivity with minimal changes in immunoreactivity. Chromatofocusing and size fractionation of the serum samples indicated the secretion of immunoreactive FSH isoforms that are devoid of bioactivity but that are capable of blocking FSH action in ovarian granulosa cells. These findings provide the first demonstration of naturally occurring circulating antihormones. These FSH antagonists may play an important role in the physiology and pathophysiology of the gonads.
R.E.C.A.M.: An Institute Research Programme (1977)

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Decentralized dynamic control of a multiaccess broadcast channel (1982)

Retransmission policies are presented for the decentralized control of a multiaccess packet-switched broadcast channel. The policies have a simple recursive form yielding a Markov description of the system. Finite average delay is achieved for an infinite-population Poisson arrival model for any rate <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\lambda < e^{-1}</tex> . It is proposed that the goal of retransmission policies should be to maintain the traffic intensity at a nearly constant, optimum level. The policies we introduce achieve this goal by nearly decoupling the dynamics of the traffic intensity from the backlog fluctuations. Analysis and simulations show that the policies perform well, even when the channel feedback information is unreliable or incomplete.
Metabolic profiles of human brain tumors using quantitative in vivo <sup>1</sup>H magnetic resonance spectroscopy (2003)

Proton spectroscopy can noninvasively provide useful information on brain tumor type and grade. Short- (30 ms) and long- (136 ms) echo time (TE) (1)H spectra were acquired from normal white matter (NWM), meningiomas, grade II astrocytomas, anaplastic astrocytomas, glioblastomas, and metastases. Very low myo-Inositol ([mI]) and creatine ([Cr]) were characteristic of meningiomas, and high [mI] characteristic of grade II astrocytomas. Tumor choline ([Cho]) was greater than NWM and increased with grade for grade II and anaplastic astrocytomas, but was highly variable for glioblastomas. Higher [Cho] and [Cr] correlated with low lipid and lactate (P < 0.05), indicating a dilution of metabolite concentrations due to necrosis in high-grade tumors. Metabolite peak area ratios showed no correlation with lipids and mI/Cho (at TE = 30 ms), and Cr/Cho (at TE = 136 ms) best correlated with tumor grade. The quantified lipid, macromolecule, and lactate levels increased with grade of tumor, consistent with progression from hypoxia to necrosis. Quantification of lipids and macromolecules at short TE provided a good marker for tumor grade, and a scatter plot of the sum of alanine, lactate, and delta 1.3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade.
Preparation, structural characterization, and dynamic properties investigation of permalloy antidot arrays (2005)

Regular nanosized structures are considered to be promising materials for magnetic information storage media with high density of information. Recently attention was paid to static and dynamic magnetic properties arising from dimensional confinement in such nanostructures. Here we present an investigation of permalloy antidot arrays of different thicknesses. Thin permalloy films of thickness ranging from 10to500nm were deposited on nanoporous Al2O3 membranes with a pore size of 100nm. It was found that additional ferromagnetic resonance peaks appear for film thicknesses below 100nm, while films with larger thicknesses show resonance properties similar to continuous films. A comparison between the films deposited onto Si wafers and porous media was done. An evolution of the domain structures observed in MFM experiments was confirmed by micromagnetic calculations.
Immune Aspects of Endometriosis: Relevance of the Uterine Mucosal Immune System (1997)

Endometriosis is classically defined as the growth of endometrial cells at sites outside the uterus. It is a common disease characterized by infertility, chronic pain and adhesion formation. Immune dysregulation, evidenced by decreased clearance of endometrial cells and aberrant production of cytokines by peritoneal fluid leukocytes, has been proposed as a mechanism which allows implantation and growth of ectopic endometrium. Cytokines are primary components of intercellular signaling between uterine epithelial and stromal cells, leukocytes, and the developing conceptus. Because their production is regulated by sex hormones, cytokines are well-placed to play a key role in the extensive tissue remodeling required to accommodate menstruation, implantation and pregnancy. Understanding this specialized hormonally-responsive mucosal immune system within the uterus will be critical to understanding the potential importance of the immune system in the pathogenesis of endometriosis. In this review, highlights of studies describing leukocyte populations, cytokines and cytokine receptors in uterine and ectopic endometrium and their proposed role in the regulation of immune processes and endometrial growth are presented, followed by a review of current data on immune aspects of endometriosis. Studies directed at investigating the hormonal regulation of cytokine secretion by uterine and peritoneal cell populations, and the effect of cytokines on endometrial proliferation, should provide a more complete understanding of their potential role in normal uterine growth and in the pathogenesis of endometriosis.
Identification of Salmonella O antigens by coagglutination (1984)

This study concerns the preparation of reagents for identifying the somatic O antigens of Salmonella enteritidis. Coagglutination reagents (COAGs) with antibody fixed to killed and stabilized protein A-bearing staphylococci were prepared with antisera which were used for identifying the somatic O antigens of S. enteritidis by the slide agglutination test. The reactions of the COAGs were compared with those obtained with the grouping antisera in routine slide agglutination tests in which 41 or more serologically different Salmonella strains, representing most of the known groups, were used. One-third of the COAGs gave identical reactions to those of the slide agglutination antisera. The reactions of the other COAGs varied from the slide agglutination antisera results, some by many reactions and others by only a few. The coagglutination procedure was more reactive than the routine slide agglutination test and resulted in cross-reactions which were not observed in the original grouping antisera. More COAGs were specific when they were tested with alcohol-treated cultures than with live cultures. Coagglutination conserves antiserum, allowing about 12 times as many tests for a given volume of group-specific glycerolized antiserum as does the slide agglutination method.
A knowledge-based consultant for financial marketing (1986)

This article describes an effort to develop a knowledge-based financial marketing consultant system. Financial marketing is an excellent vehicle for both research and application in artificial intelligence (AI). This domain differs from the great majority of previous expert system domains in that there are no well-defined answers (in traditional sense); the goal here is to obtain satisfactory arguments to support the conclusions made. A large OPS5-based system was implemented as an initial prototype. We present the organization and principles underlying this system and offer our ongoing research directions. The experience gained in the initial prototyping effort is currently being used to further expert systems research and to develop an extensive system that ultimately can be used by the marketing organization.