gebhart/patrepeval huggingface dataset:
Laser polishing and laser shape correction of optical glass (2017)

Mechanical polishing of glass is a time consuming process especially for lenses deviating from spherical surface such as aspheres. With laser polishing, the processing time can be significantly reduced and the wear of hard tooling can be avoided. Using laser radiation for polishing, a thin surface layer of the glass is heated up just below evaporation temperature due to the interaction of glass material and laser radiation. With increasing temperature, the reduced viscosity in the surface layer leads to the reduction of the roughness due to the surface tension. Hence, a contactless polishing method can be realized nearly without any loss of material or need of polishing agent. In this paper, results for laser polishing of fused silica, BK7, and S-TIH6 are presented with area rates up to 5 cm2/s. However, the results show that the achieved roughness with laser polishing is strongly influenced by the thermal properties of the type of glass. During laser polishing, the glass material is relocated at the surface, thus no shape errors can be corrected. To reduce the residual waviness and shape errors after laser polishing, the authors investigated a further laser-based process step (laser beam figuring, LBF) which ablates material for a shape correction. Ablation depths &lt;5 nm allow a high precision laser ablation for selective processing. For both processes, a CO2 laser is used.
Origami simulator (2009)

We present a 3D origami simulator with multi-touch interaction. This is a preliminary exploration of manipulating 3D models with multi-touch. Following a user centered approach, we analyzed how people make paper origami models and mapped the common actions into two-touch gestures. The user study suggested that people enjoyed the simulator and think the techniques can be applied to other 3D modeling environments.
A Coverage Guided Mining Approach for Automatic Generation of Succinct Assertions (2014)

Machine learning techniques are widely employed for automatic assertion generation in hardware verification. Our previous method [16] uses a decision tree based approach for mining assertions and does not have design coverage related feedback. The assertions are unaware of the design, over-constrained and have low expressiveness. We introduce a coverage guided mining approach for mining assertions from simulation traces. Our approach combines association rule learning, greedy set covering and formal verification. It circumvents the exhaustive rule generation of association mining using coverage feedback. The algorithm has been implemented as one part of GoldMine <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . Experiments using a variety of designs, including USB, PCI and OpenRisc, show that the assertions generated by coverage guided association mining cover an average of 6.14 times input space than those generated by decision tree based mining algorithms. We also show that the coverage guided association mining produces an average of 2.75 times fewer propositions per assertion than decision tree based mining. All these mean the assertions generated by coverage guided association mining are more succinct, and of higher value for hardware design verification.
Azacytidine (Vidaza�) in the treatment of myelodysplastic syndromes (2006)

The myelodysplastic syndromes (MDS) are a heterogeneous group of disorders that manifest as bone marrow failure with the risk of life threatening infections and bleeding. A third of these patients may transform to acute leukemia. Age and co-morbidities have limited treatment in the majority to supportive care with a minority of patients eligible for the only curative modality to date, allogeneic stem cell transplantation. The advent of targeted therapy has increased the repertoire of therapeutic options. In particular the methyl transferase inhibitor 5 Azacytidine, that targets epigenetic changes in MDS, has been shown to be effective in up to 60% of patients in a Phase III randomized controlled trial comparing it with best supportive care and has been licensed by the US Food and Drug Administration for use in all subtypes of MDS. It has been shown to prolong time to leukemic transformation (21 vs 12 months with 3% transforming to leukemia p=0.0001) and is the only disease-modifying drug. Patients with monosomy 7, trisomy 8, and diploid chromosomes appear to particularly benefit with the former deriving sustained remissions. As an outpatient therapy, with an acceptable side effect profile, treatment with Azacytidine needs to be considered in all MDS patients who are eligible for treatment.
Student as Producer: Using Research-Engaged Teaching to Enhance the Learning Experience of Biomechanics Students (2015)

With the changing landscape of the higher education system in the United Kingdom, ways in which programme teams respond to develop the curriculum, meeting the shifting demands of the student, has becomes a challenge for all those involved in teaching. Higher education should capture the interest of students and inspire them to learn, by relating the content to novel research as well as to the students' life. Lecturers should expose students to different teaching methods optimising both their understanding and their ability to apply this knowledge to different scenarios. Consequently, lecturers need to continuingly develop new ways of teaching, aiding and inspiring learning to take place. Students should have the capacity to process, apply, and critique the information given to them and then create meaning as to validity, reliability, and general usefulness of the information provided.
A generic statistical-based UWB channel model for high-rise apartments (2005)

A generic statistical-based ultrawide-band (UWB) indoor channel model which incorporates the clustering of multipath components (MPCs) is proposed. The model is derived using measurement data collected in the frequency band of 3-10 GHz in various types of high-rise apartment under different propagation scenarios. The measurement procedure allows the characterization of both the large-scale and the small-scale statistics of the channel. The main objective is to study multipath propagation behavior, particularly the phenomenon of clustered MPCs. The description of clustering observed in the channel uses two classes of parameters which characterize the clustering and the MPCs respectively. All parameters are described by a set of empirical probability density functions derived from the measured data such as the distribution of clusters and MPCs, cluster and MPC arrival statistics and small-scale amplitude fading statistics. A new distribution, namely, a mixture of two Poisson processes, is proposed to model the ray arrival times. This new distribution fits the empirical data better than the single Poisson process proposed in the conventional Saleh-Valenzuela (S-V) model. Analysis results show that the small-scale amplitude fading statistics are best modeled by the Weibull distribution. The Weibull b-shape parameter is lognormally distributed and is found to be invariant across the excess delay. Additionally, the temporal correlation between adjacent path amplitudes is investigated. The amplitude temporal correlation coefficients are found to be relatively small, and thus, can be assumed to be negligible in reality. The proposed model can provide a realistic simulation platform for UWB communication systems.
High-Yield Expression and Functional Analysis of <i>Escherichia coli</i> Glycerol-3-phosphate Transporter (2001)

The glycerol-3-phosphate (G3P) transporter, GlpT, from Escherichia coli mediates G3P and inorganic phosphate exchange across the bacterial inner membrane. It possesses 12 transmembrane alpha-helices and is a member of the Major Facilitator Superfamily. Here we report overexpression, purification, and characterization of GlpT. Extensive optimization applied to the DNA construct and cell culture has led to a protocol yielding approximately 1.8 mg of the transporter protein per liter of E. coli culture. After purification, this protein binds substrates in detergent solution, as measured by tryptophan fluorescence quenching, and its dissociation constants for G3P, glycerol-2-phosphate, and inorganic phosphate at neutral pH are 3.64, 0.34, and 9.18 microM, respectively. It also shows transport activity upon reconstitution into proteoliposomes. The phosphate efflux rate of the transporter in the presence of G3P is measured to be 29 micromol min(-1) mg(-1) at pH 7.0 and 37 degrees C, corresponding to 24 mol of phosphate s(-1) (mol of protein)(-1). In addition, the glycerol-3-phosphate transporter is monomeric and stable over a wide pH range and in the presence of a variety of detergents. This preparation of GlpT provides ideal material for biochemical, biophysical, and structural studies of the glycerol-3-phosphate transporter.
Evaluation of modal noise in multimode fiber-optic systems (1984)

Modal noise at fiber connecting points is studied theoretically and experimentally. Simple formulas for calculating modal-noise power, noise bandwidth, and nonlinear distortions are obtained by introducing a visibility concept. Modal noise for multimode operating LD is also analyzed. These theoretical results are applied to high-bit-rate digital systems and analog systems using direct IM. Then, it is shown that a 3-dB connection loss limits effective signal-to-noise ratio (SNR) to 22 dB in high-bit-rate digital systems, and that in analog systems, the SNR is improved more than 20 dB by using a superimposed pulse modulation with a frequency that is 100 times the baseband signal bandwidth.
PARADOXICAL ACTION OF GLYCERYL TRINITRATE (NITROGLYCERIN) IN CORONARY PATIENTS (1955)

For more than 75 years, no drug has proved superior to glyceryl trinitrate (nitroglycerin) in warding off or cutting short attacks of angina pectoris. Most observers have attributed the beneficial action of this agent to its vasodilating effect on the coronary arteries. On the other hand, while favorable therapeutic response in most patients is an established fact, clinical experience has proved that, in certain cases, the use of nitrites is not followed by clinical improvement1and may even cause untoward effects. A considerable number of reports in the literature make it clear that glyceryl trinitrate is not a perfectly harmless drug and that there exists a significant incidence of collapse, syncope, and less severe reactions of cardiovascular nature after its administration.2Usually such reactions are ascribed either to overdosage or to an individual sensitivity of the patient. The causes of such reactions are readily discernible, however, if one
THREE-DIMENSIONAL MODELING OF QUASI-HOMOLOGOUS SOLAR JETS (2010)

International audience
Feature engineering for mobile (SMS) spam filtering (2007)

Mobile spam in an increasing threat that may be addressed using filtering systems like those employed against email spam. We believe that email filtering techniques require some adaptation to reach good levels of performance on SMS spam, especially regarding message representation. In order to test this assumption, we have performed experiments on SMS filtering using top performing email spam filters on mobile spam messages using a suitable feature representation, with results supporting our hypothesis.
A Polynomial time Algorithm for 2-layer Channel Routing Problem (2012)

Channel routing in the 2-layer Manhattan model is one of the most investigated problems in VLSI design. David Szeszler [Szeszler D., A New Algorithm for 2-layer, Manhattan Channel Routing, Proc. 3rd Hungarian-Japanese Symposium on Discrete Mathematics and Its Applications (2003), 179–185] gave a complete characterization of all specifications that are solvable and present a linear time algorithm to solve these specifications with a width at most constant times the length of the problem. In this paper an efficient graph theoretic algorithm for a particular 2-layer Manhattan channel routing problem has been presented, we give a new polynomial time algorithm to solve these specifications with a width better than the result of David Szeszler.
Leveraging inconsistency in software development (2000)

Software engineers make use of many descriptions, including analysis models, specifications, designs, program code, user guides, test plans, change requests, style guides, schedules, and process models. But since different developers construct and update these descriptions at various times during development, maintaining consistency among descriptions presents several problems. Descriptions tend to vary considerably. Individual descriptions can be ill-formed or self-contradictory and frequently evolve throughout the life cycle at different rates. Also, checking the consistency of a large, arbitrary set of descriptions is computationally expensive. The authors assert that maintaining consistency at all times is counterproductive. In many cases, it may be desirable to tolerate or even encourage inconsistency to facilitate distributed team-work and prevent premature commitment to design decisions. They advocate using inconsistency to highlight problem areas, using it as a tool to improve the development team's shared understanding, direct the process of requirements elicitation, and assist with verification and validation.
Decades of research in drug targeting to the upper gastrointestinal tract using gastroretention technologies: where do we stand? (2014)

A major constraint in oral controlled release drug delivery is that not all the drug candidates are absorbed uniformly throughout the gastrointestinal tract (GIT). Drugs having "absorption window" are absorbed in a particular portion of GIT only or are absorbed to a different extent in various segments of the GIT. Thus, only the drug released in the region preceding and in close vicinity to the absorption window is available for absorption. The drug must be released from the dosage form in solution form; otherwise, it is generally not absorbed. Hence, much research has been dedicated to the development of gastroretentive drug delivery systems that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs, as these systems have unique properties to bypass the gastric emptying process. These systems show excellent in vitro results but fail to give desirable in vivo performance. During the last 2-3 decades, researchers from the academia and industries are giving considerable importance in this field. Unfortunately, till date, few so-called gastroretentive dosage forms have been brought to the market in spite of numerous academic publications. The manuscript considers strategies that are commonly used in the development of gastroretentive drug delivery systems with a special attention on various parameters, which needs to be monitored during formulation development.
17β-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange (2006)

17beta-estradiol increases HUVEC water content and HUVEC elasticity mediated by activated estrogen receptors. The estrogen response depends on the activation of plasma membrane Na(+)/H(+) exchange. The increase in endothelial cell elasticity could be one of the vasoprotective mechanisms postulated for 17beta-estradiol.
Congestion control for high speed packet switched networks (2002)

The authors suggest and investigate a general input congestion control scheme that takes into account a broad spectrum of network issues. As a preventive congestion control strategy, a leaky-bucket-type scheme operating on a session basis that limits the session's average rate and the burstiness is proposed. This restrictive control is combined with an optimistic bandwidth usage scheme which works by marking packets into two different colors, green and red. The packets are marked so that the average green packet rate entering the network is at the reserved average rate. The average red packet rate represents traffic in excess of this guaranteed average rate and is sent to further utilize unused bandwidth in the network. Both types of packets are further filtered by a spacer which limits the peak rate at which the packets enter the network. The marked packets are then sent into the network, where they are treated according to their color, using at each intermediate node a simple threshold policy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Filtered detector arrays for single pulsed photon measurements above 100 keV (1977)

We discuss the design of filtered detector arrays for single pulsed, 100 keV photon spectral and angular distribution measurements at the Lawrence Livermore Laboratory Argus laser facility.
Synthesis of cyclic disulfide peptides: comparison of oxidation methods (1997)

Abstract: Seven cyclic disulfide peptides (oxytocin, salmon calcitonin 1-10, CTP, crustacean cardioactive peptide, somatostatin 3-14, [C2•6]-P-endorphin 1-6 and endothelin-P 3-11) were synthesized on soli<:1 phase and cyclized either on the resin, simultaneously with the cleavage from the resin, or in solution after cleavage, using eight different oxidation methods. The purities of the crude peptides were compared in order to evaluate the efficacy of the different oxidation methods with respect to the peptide sequences.
Thomas V. McEvilly (2002)

Research Article| July 01, 2002 Thomas V. McEvilly Lane Johnson Lane Johnson Seismological Laboratory University of California Berkeley, California 94720 Search for other works by this author on: GSW Google Scholar Author and Article Information Lane Johnson Seismological Laboratory University of California Berkeley, California 94720 Publisher: Seismological Society of America First Online: 09 Mar 2017 Online ISSN: 1938-2057 Print ISSN: 0895-0695 © 2002 by the Seismological Society of America Seismological Research Letters (2002) 73 (4): 455–456. https://doi.org/10.1785/gssrl.73.4.455 Article history First Online: 09 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Lane Johnson; Thomas V. McEvilly. Seismological Research Letters 2002;; 73 (4): 455–456. doi: https://doi.org/10.1785/gssrl.73.4.455 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietySeismological Research Letters Search Advanced Search Tom McEvilly passed away on February 22 after a courageous eight-month battle against a difficult form of cancer, a poorly differentiated carcinoma of unknown primary origin. With his passing the field of seismology lost a very gifted scientist and many seismologists lost a close friend. Tom is survived in his immediate family by his wife Dottie, six children (Mary, Susan, Ann, Steve, Joe, and Adrian), and nine grandchildren. His family has requested that a graduate fellowship be established at UC Berkeley to honor his memory and to support graduate studies in the field of seismology. Information about this fellowship and... You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
An HMM-based system for automatic segmentation and alignment of speech (2003)

This paper describes an automatic speech alignment system developed for Swedish, which is an extension to earlier work in this area (Sjlander 2001). The system takes as input speech sound files and matching text files containing word-level transcriptions of the speech. A specialised speech recognition system, based on Hidden Markov Models, is applied and a time aligned phone-level transcription is produced
Dynamic control of split flow in packed column supercritical fluid chromatography using dual resistively heated restrictors (2009)

Remote control of the vent/detector split flow ratio in packed column supercritical fluid chromatography (pSFC) with flame ionization detector (FID) is demonstrated using a dual heated restrictor method. Restrictors stemming from a Tee at the separation column outlet were, respectively, fixed into an FID and a vent port, and their individual temperatures were controlled using resistively heated wires. Subsequently, both system pressure and split flow could be manipulated. For example, for applied restrictor temperatures examined up to 600 degrees C, corresponding vent/FID split flow ratios between 2 and 7 were observed depending on the port heated. As well, column pressures around 16-23 MPa were also achievable over the same range. Conversely, isobaric altering of the split flow ratio was possible when opposing positive and negative temperature gradients were applied at the two restrictors. Under these conditions, the system pressure varied less than 1% RSD over a 10 min period. As an application, the method was used to establish stable detector operation in the analysis of n-alkanes under pSFC-FID conditions that initiated flame instability. Results indicate that this technique could be a relatively simple and inexpensive means of controlling system pressure and detector split flow ratios in pSFC-FID.
Assessment of two herbicide wiping devices (2000)

If herbicides were wiped on to weeds rather than sprayed the risk of spray drift would be eliminated Two devices designed to apply herbicides using rolling wipers were assessed for their ability to apply constant amounts of herbicide to treated surfaces The Weed Ball Applicator treated strips only 36 mm wide despite having a roller 100 mm wide whereas the Turf Girl applicator delivered a 500 mm wide band Both applicators suffered from a tendency to apply less herbicide as the herbicide reservoir emptied with the nearly empty Weed Ball delivering only 124 of that applied when full Adjustments to the flow rate as the reservoir emptied could be made using a tap in both devices A field evaluation of the Weed Ball applicator on dichondra showed that it had good potential for selective localized applications of herbicides to lawn weeds Of the treatments evaluated a metsulfuron solution (045 g/litre) gave the best control
Viruses in Idiopathic Pulmonary Fibrosis. Etiology and Exacerbation (2015)

Viral infections are important contributors to exacerbation of asthma and chronic obstructive pulmonary disease; however, the role of viruses in the pathogenesis of idiopathic pulmonary fibrosis (IPF) is less clear. This likely reflects that fact that IPF acute exacerbations are defined clinically as "noninfectious," and little attention has been paid to the outcomes of patients with IPF with diagnosed infections. However, accumulating evidence suggests that infections (both bacterial and viral) may influence disease outcomes either as exacerbating agents or initiators of disease. Support for a viral role in disease initiation comes from studies demonstrating the presence of herpesviral DNA and epithelial cell stress in the lungs of asymptomatic relatives at risk for developing familial IPF. In addition, the number of studies that can associate viral (especially herpesviral) signatures in the lung with the development of IPF is steadily growing, and activated leukocyte signatures in patients with IPF provide further support for infectious processes driving IPF progression. Animal modeling has been used to better understand how a gamma herpesvirus infection can modulate the pathogenesis of lung fibrosis and has demonstrated that preceding infections appear to reprogram lung epithelial cells during latency to produce profibrotic factors, making the lung more susceptible to subsequent fibrotic insult, whereas exacerbations of existing fibrosis, or infections in susceptible hosts, involve active viral replication and are influenced by antiviral therapy. In addition, there is new evidence that bacterial burden in the lungs of patients with IPF may predict a poor prognosis.