gebhart/patrepeval huggingface dataset:
Raman spectroscopy of phenylcarbyne polymer films under pulsed green laser irradiation (2000)

The polycarbyne polymer films were coated on silicon substrates and then irradiated by a pulsed Nd:yttrium–aluminum–garnet laser (λ=532 nm) with various fluences in argon gas atmosphere. Significant changes in microstructures and chemical bonding (sp3/sp2) during laser treatment were investigated by Raman spectroscopy. At a laser fluence below 50 mJ/cm2, the Raman spectrum of the film was similar to that of the original polymer film. In a fluence range from 100 to 650 mJ/cm2, the thermal decomposition of the polymer occurred, resulting in upshift of G peak and downshift of the D peak both with narrower peak width. With increasing laser fluence from 650 to 950 mJ/cm2, both the G and D peaks downshifted simultaneously due to the thermal decomposition. The simultaneous downshift of both peaks indicated the increased sp3/sp2 ratio in the carbon film converted from the polymer. With increasing laser fluence in this range, the thermal decomposition also induced the narrowing of both peaks. The narrowing of both peaks indicated the increased ordering of sp3 and sp2 bonding components in the converted carbon film. The scanning electron microscopy studies provided the further evidence. The carbon films converted from the polymer films may contain the highest sp3 carbon bonding at laser fluences in the range from 850 to 1000 mJ/cm2.
Preparation of highly sulfonated polystyrene model colloids (1989)

Abstract Previous attempts to prepare monodisperse styrene/sodium styrene sulfonate copolymer latexes by batch, seeded, and semicontinuous emulsion polymerization were unsuccessful at high concentrations of the functional comonomer. Broad, and sometimes bimodal, size distributions, and large amounts of water soluble homopolymer were obtained. After removal of free monomer, solute and adsorbed homopolymer and copolymer, the overall incorporation of the functional comonomer was found to be low. To overcome these problems, a two stage “shot‐growth” or in situ seeding technique was developed. A first stage copolymerization was carried out with a low concentration of sodium styrene sulfonate: the purpose of the functional comonomer was to enhance the stability and regulate the size of the seed particles. When this reaction had reached high conversion (> 90%), a second stage monomer mixture was added. The ratio of styrene to sodium styrene sulfonate in this mixture determined the final surface charge density. The mechanism by which the NaSS is incorporated in the polymer particles is considered to be by solution copolymerization with solute styrene monomer to form surface active oligoradicals. These radicals adsorb on the particle surface, initiate polymerization and become inextricably bound, preventing their transfer back to the aqueous phase. By this means, it was possible to vary independently the particle size and surface charge density. High concentrations of functional comonomer could be polymerized without undue wastage (incorporations were only slightly less than 100%) or loss of monodispersity. In extreme cases, the area per functional group fell below the theoretical minimum, indicating considerable hydration of the surface layers.
Speech Rate Determination By Vowel Detection On The Modulated Energy Envelope (2014)

Publication in the conference proceedings of EUSIPCO, Lisbon, Portugal, 2014
Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa (2015)

Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in COL7A1 resulting in reduced or absent type VII collagen, aberrant anchoring fibril formation and subsequent dermal-epidermal fragility. Here, we identify a significant decrease in PLOD3 expression and its encoded protein, the collagen modifying enzyme lysyl hydroxylase 3 (LH3), in RDEB. We show abundant LH3 localising to the basement membrane in normal skin which is severely depleted in RDEB patient skin. We demonstrate expression is in-part regulated by endogenous type VII collagen and that, in agreement with previous studies, even small reductions in LH3 expression lead to significantly less secreted LH3 protein. Exogenous type VII collagen did not alter LH3 expression in cultured RDEB keratinocytes and we show that RDEB patients receiving bone marrow transplantation who demonstrate significant increase in type VII collagen do not show increased levels of LH3 at the basement membrane. Our data report a direct link between LH3 and endogenous type VII collagen expression concluding that reduction of LH3 at the basement membrane in patients with RDEB will likely have significant implications for disease progression and therapeutic intervention.
Close pair queries in moving object databases (2005)

Databases of moving objects are important for air traffic control, ground traffic, and battlefield configurations. We introduce the (historical and spatial) range close-pair query for moving objects as an important problem for such databases. The purpose of a range close-pair query for moving objects is to find pairs of objects that were closer than ε during time interval $I$ and within spatial range R, where ε, I and R are user-specified parameters.This paper solves the range close-pair query using two components: the retrieval component and the close-pair identification component. The retrieval component breaks up long trajectories into trajectory segments, which are produced in increasing time order, without the need for sorting. The retrieval component takes advantage of a new index mechanism, the Multiple TSB-tree. The segments are then pipelined to the close-pair identification component. The identification component introduces a novel spatial sweep that sweeps by time and one spatial dimension at the same time. Extensive experimental results are provided, demonstrating the advantages of the new approach when considering close pairs.
Chemistry of soil minerals. Part VI. Salt entrainment by sodalite and cancrinite during their synthesis. (1970)

The imbibition of salts by sodalite and cancrinite during their hydrothermal formation from kaolinite has been studied. Isotherm contours recalling those of Langmuir's isotherm were observed in sodalite for NaCl, NaBr, NaClO3, NaClO4, and Na2CO3. These results have been interpreted in terms of a Donnan equilibrium, in which solid-phase activities were calculated on the experimentally justified assumption that each sodalite cage is capable of accommodating a particular number of each kind of guest molecule, which number varies with the size of the guest. The stoicheiometry, thermal stability, chemical reactivity, and crystallization kinetics of representative compounds have been discussed, and the possible importance of salt inclusion in other zeolitic materials has been noted.
Impaired autophagy in Lafora disease (2010)

Lafora disease (LD) is a progressive, lethal, autosomal recessive, neurodegenerative disorder that manifests with myoclonus epilepsy. LD is characterized by the presence of intracellular inclusion bodies called Lafora bodies (LB), in brain, spinal cord and other tissues. More than 50 percent of LD is caused by mutations in EPM2A that encodes laforin. Here we review our recent findings that revealed that laforin regulates autophagy. We consider how autophagy compromise may predispose to LB formation and neurodegeneration in LD, and discuss future investigations suggested by our data.
Anti-hemophilic factor (recombinant), plasma/albumin-free method (octocog-alpha; ADVATE) in the management of hemophilia A. (2007)

Removal of blood-based additives from recombinant clotting factor concentrates continues to be advocated by the hemophilia community due to the history of infectious disease transmission with previous blood-derived clotting factor concentrates. In 2003, octocog-alpha, antihemophilic factor (recombinant), plasma/albumin-free method (ADVATE) was introduced, providing the first third-generation recombinant factor VIII (rFVIII) concentrate. Completed clinical trials have demonstrated ADVATE to be safe and effective in adult and pediatric subjects utilizing both prophylactic and on-demand treatment regimens, and for perioperative hemostatic coverage. In the five completed studies involving more than 200 previously treated patients (PTPs), a single incidence of low-titer, non-persistent inhibitor was reported. Active post authorization safety surveillance (PASS) is being performed to expand the efficacy and safety profile of ADVATE in routine clinical practice. Laboratory studies have documented the storage and post-reconstitution stability of ADVATE, conferring the desired versatility for home treatment. The evolving real-world experience and ongoing studies will provide further insight into ADVATE pharmacokinetics, alternative prophylactic dosing regimens, methods for perioperative hemostatic management, and utility in immune tolerance induction. Experience with ADVATE, and its place in today's treatment paradigm, is the focus of this article.
Is there a case for P-450 inhibitors in cancer treatment? (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIs there a case for P-450 inhibitors in cancer treatment?Jean P. Van Wauwe and Paul A. J. JanssenCite this: J. Med. Chem. 1989, 32, 10, 2231–2239Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/jm00130a001https://doi.org/10.1021/jm00130a001research-articleACS PublicationsRequest reuse permissionsArticle Views189Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cellophane-Dye Dosimeter for 10<sup>5</sup> to 10<sup>7</sup> Roentgen Range (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCellophane-Dye Dosimeter for 105 to 107 Roentgen RangeE. J. Henley and David. RichmanCite this: Anal. Chem. 1956, 28, 10, 1580–1582Publication Date (Print):October 1, 1956Publication History Published online1 May 2002Published inissue 1 October 1956https://pubs.acs.org/doi/10.1021/ac60118a023https://doi.org/10.1021/ac60118a023research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intramolekulare Aromatenalkylierungen, 29. Mitt.<sup>1)</sup>: Synthese und Bestimmung der absoluten Konfiguration von 1‐Acetylindolin‐3‐carbonsäure (1990)

Abstract Der durch Grignardierung von Indol mit Chlorameisensäureester erhältliche Ester 4 gibt mit Acylhalogeniden unter Phasentransferkatalyse die 1‐Acylderivate 6 , von denen 6a,b mit Pd oder Rh zu den Indolin‐3‐carbonsäureestern (±)‐ 7a,b hydriert werden. Nach Verseifung zu (±)‐ 8a,b wird (±)‐ 8a mit (−)‐S‐ bzw. (+)‐R‐Phenylethylamin über die Diastereomerensalze 9 in die Enantiomeren (+)‐ bzw. (−)‐ 8a gespalten. Diese geben mit L‐Phe‐Ester selektiv die diastereomeren Peptide (+)‐bzw. (−)‐ 10 , die in gleicher Weise auch aus dem Racemat (±)‐ 8a und anschließender SC erhalten werden. Nach Röntgenstrukturanalyse von (+)‐ 10 ist C‐3 S‐konfiguriert, woraus die absol. Konfiguration für die Enantiomeren 8a als (+)‐3S und (−)‐3R resultiert.
Thermal Effect of TSVs in 3D Die-Stacked Integrated Circuits (2011)

Shorter interconnects and higher integration are among the benefits that 3D die-stacking is expected to bring to future integrated circuits. However, when stacking power-dissipating dies one on top of the other, the total power density increases accordingly. As a result, temperatures in 3DICs are exacerbated. TSVs are regarded as a solution since they are made of copper and have a high thermal conductivity. In this paper, both the global and the local thermal effects of TSVs are evaluated by means of a framework based on FEM. By using a TSV grid covering a whole IC, it is shown that, on a global scale, TSVs make the overall average temperature drop slightly. Furthermore, on a local scale, it is shown that the insertion of TSVs near a hotspot has an effect that not only depends on the density of the TSVs but also on how they are arranged. Our experiments have also revealed that other parameters, such as the thermal conductivity of the material in which the hotspot is located, may influence the cooling efficiency of the TSVs.
Virtual surgery system with haptic sensation for both hands (2002)

The authors have developed a virtual surgery system which is able to handle organs as elastic models and obtain a haptic sensation with force feedback in real time. They tried to design a system that would allows them to physically manipulate, or incise these soft tissue models in virtual space. When the elastic organs are significantly incised both the organ's surface and inner structures become deformed or distorted. These changes occur at a speed identical to real time. The features of the device developed for the authors' virtual surgery system are summarized as follows. At first, the force feedback system is divided in two types of manipulators, a force control manipulator and a motion control manipulator. The authors tried to design three force control manipulators for fingers. These are attached to the end of the motion control manipulator. Second, both ends of each force control manipulator are attached to the thumb, forefinger and middle finger of the operator. The user is able to handle an elastic organ using two manipulators on the right and left hands. In the authors' virtual surgery system, it is possible to perform surgical maneuvers at a speed approaching that of the actual procedure, while experiencing a sense of touch. Here, the authors have applied this system to surgery in the abdominal region. This surgical experience, in which a patient's morphological characteristics are reproduced in a virtual environment, will allow the establishment of a new method of clinically applicable surgery as well as an educational innovation.
Development of Titanium-based Brazing Filler Metals with Low-melting-point (2002)

Titanium and titanium alloy are excellent in corrosion resistance and specific intensity, and also in the biocompatibility. On the other hand, the brazing is bonding method of which productivity and reliability are high, when the complicated and precise structure of the thin plate is constructed. However, though conventional titanium-based brazing filler metal was excellent in bond strength and corrosion resistance, it was disadvantageous that metal structure and mechanical property of the base metal deteriorated, since the brazing temperature ( about IOOO°C ) is considerably high. Authors developed new brazing filler metal which added Zr to Ti-Cu (-Ni) alloy which can be brazed at 900°C or less about 15 years ago. 
In this paper, the development of more low-melting-point brazing filler metal was tried by the addition of the fourth elements such as Ni, Co, Cr for the Ti-Zr-Cu alloy. As a method for finding the low-melting-point composition, eutectic composition exploration method was used in order to reduce the experiment point. 
As the result, several kinds of new brazing filler metal such as 37.5Ti-37.5-Zr-25Cu alloy (melting point: 825°C) and 30Ti-43Zr-25Cu-2Cr alloy (melting point: 825°C) was developed. Then, the brazing joint showed the characteristics which were almost equal to the base metal from the result of obtaining metallic structure and strength of joint of brazing joint. However, the brazing filler metal composition of the melting point of 820°C or less could not be found. Consequentially, it was clarified that the brazing filler metal developed in this study could be practically sufficiently used from results such as metal structure of brazing joint and tensile test of the joint.
Paintable band-edge liquid crystal lasers (2011)

In this paper we demonstrate photonic band-edge laser emission from emulsion-based polymer dispersed liquid crystals. The lasing medium consists of dye-doped chiral nematic droplets dispersed within a polymer matrix that spontaneously align as the film dries. Such lasers can be easily formed on single substrates with no alignment layers. The system combines the self-organizing periodic structure of chiral nematic liquid crystals with the simplicity of the emulsion procedure so as to produce a material that retains the emission characteristics of band-edge lasers yet can be readily coated. Sequential and stacked layers demonstrate the possibility of achieving simultaneous multi-wavelength laser output from glass, metallic, and flexible substrates.
A 4-bit RF MEMS phase shifter monolithically integrated with conventional CMOS (2011)

This paper presents the design and characterization of the first RF MEMS phase shifter to be monolithically integrated with conventional CMOS using maskless post-CMOS etching. The phase shifter consists of a micromachined transmission line periodically loaded with 4-bit MEMS digital capacitors, which are controlled using a combination of vertical electrothermal and lateral electrostatic actuation. MIM capacitors are embedded in the transmission line in series with MEMS capacitors to trade tuning ratio for increased capacitor Q. Measured results of the phase shifter at 32 GHz show an average insertion loss of 2.9 dB and a maximum phase shift of 337.5° in 16 steps.
Transient exposure to sodium butyrate after germinal vesicle breakdown improves meiosis but not developmental competence in pig oocytes (2012)

Oocyte maturation is a complex process during which epigenetic modifications are dramatically changed, especially histone acetylation and phosphorylation. We have investigated the effects of NaBu (sodium butyrate), a natural HDAC (histone deacetylase) inhibitor, on porcine oocyte maturation at different stages and subsequent embryonic development to improve IVF (in vitro fertilization) and embryo production. COCs (cumulus oocyte complexes) were cultured, IVM (in vitro maturation) supplemented with 1 mM NaBu before or after GVBD [GV (germinal vesicle) breakdown] during maturation. NaBu delayed oocyte meiosis in the GV and GVBD stages in an exposure-dependent manner. However, the short treatment with 1 mM NaBu after GVBD significantly improved the meiotic competence. No positive effects of NaBu on GSH levels and subsequent embryonic development following IVF were seen. Transient exposure to NaBu after GVBD improves meiotic competence, but not subsequently, probably by having an effect on histone acetylation during oocyte maturation.
CD133-positive cancer stem cells from colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile (2014)

During the past decade, cancer stem-like cells (CSCs) have drawn substantial interest in cancer research since they have been described as major targets to improve treatment of tumors and to prevent recurrence and metastasis. In this paper, we report on the search for CSCs within the Colo205 human adenocarcinoma cell line. We describe that CD133 (prominin) was the only reliable marker for the isolation and characterization of CSCs within a Colo205 cell population. CD133-positive cells displayed many CSC characteristics, such as tumorsphere formation ability, expression of early-stage development markers, high invasiveness, raised tumor initiation potential and resistance to cisplatin chemotherapy treatment. In vitro analyses also highlighted a specific metabolomic profile of CD133-positive cells and we concluded that the chemotherapy resistance of CSCs could be related to the quiescence of such cells associated with their reduced metabolism. Furthermore, in vivo metabolome analyses suggested that a high level of circulating glutathione molecules could also promote treatment resistance. From the perspective of metabolomics, we also discuss the controversial use of serum-free in vitro cultures for CSC enrichment prior to further phenotype characterization.
A hybrid real-time face tracking system (2002)

A hybrid real-time face tracker based on both sound and visual cues is presented. Initial talker locations are estimated acoustically from microphone array data while precise localization and tracking are derived from image information. A computationally efficient algorithm for face detection via motion analysis is employed to track individual faces at rates up to 30 frames per second. The system is robust to nonlinear source motions, complex backgrounds, varying lighting conditions, and a variety of source-camera depths. While the direct focus of this work is automated video conferencing, the face tracking capability has utility to many multimedia and virtual reality applications.
Clinical Effect of Subgingivally Delivered Simvastatin in the Treatment of Patients With Chronic Periodontitis: A Randomized Clinical Trial (2010)

There was a greater decrease in gingival index and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in patients with chronic periodontitis.
Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits (2013)

Motor behaviors result from the interplay between the brain and the spinal cord. Reticulospinal neurons, situated between the supraspinal structures that initiate motor movements and the spinal cord that executes them, play key integrative roles in these behaviors. However, the molecular identities of mammalian reticular formation neurons that mediate motor behaviors have not yet been determined, thus limiting their study in health and disease. In the medullary reticular formation of the mouse, we identified neurons that express the transcription factors Lhx3 and/or Chx10, and demonstrate that these neurons form a significant component of glutamatergic reticulospinal pathways. Lhx3-positive medullary reticular formation neurons express Fos following a locomotor task in the adult, indicating that they are active during walking. Furthermore, they receive functional inputs from the mesencephalic locomotor region and have electrophysiological properties to support tonic repetitive firing, both of which are necessary for neurons that mediate the descending command for locomotion. Together, these results suggest that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.