gebhart/patrepeval huggingface dataset:
Serratia Infections: from Military Experiments to Current Practice (2011)

Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens, were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens, and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens, this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens, and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.
Sodium versus Meglumine Diatrizoate in Excretory Urography (1974)

In anesthetized dogs the i.v. injection of mannitol, sodium diatrizoate, meglumine diatrizoate or meglumine hydrochloride produced diuresis approaching a steady-state. During this period the apparent volumes of distribution of meglumine and diatrizoate were similar and greater than that of inulin; the plasma concentration, renal clearance, and rate of urinary excretion were the same for meglumine and diatrizoate; their renal clearance was identical with that of inulin. Excretion of urine and urinary electrolytes was greater after meglumine diatrizoate than after sodium diatrizoate or meglumine hydrochloride. Urinary concentration of diatrizoate was greater after sodium than after meglumine diatrizoate; the relative radiopacities should be as 11/9. This difference is believed to result from the influence of the two impermeant ions on the excretion of other ions on a statistical basis. Single-dose experiments revealed no such difference between sodium and meglumine diatrizoates due to errors arising from collection of urine from the bladder.
ChemInform Abstract: A Quantum Theory of Molecular Structure and Its Applications (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Neuro-fuzzy networks for short-term wind power forecasting (2010)

This paper presents a statistical model based on a hybrid computational intelligence technique that merging neural networks and fuzzy logic for wind power forecasting. A mesoscale NWP model is used to forecast meteorological variables at a reference point of a wind farm for the next 36 hours at half-hour intervals. The output of the NWP model, together with measured data form SCADA and wind tower, is processed by the proposed model to accurately forecast the wind power of each wind turbine in the wind farm. The network architecture and the training algorithm are introduced. The forecasting approach is applied for the wind power forecasting of a real wind farm located in China. The root mean square errors (RMSE) between the forecasted wind power and actual wind power are less than 20%. From the forecasting results obtained, we conclude: The trained neuro-fuzzy networks are powerful for modeling the wind farm and forecasting the wind power. Due to the adaptability of neuro-fuzzy networks, the proposed approach can be integrated into an on-line wind power forecasting system that automatically be tuned during operation.
Computer Applications in Directional Solidification Processing (1976)

Directional solidification has progressed from the laboratory stage to the production floor within the last decade. Applications include directionally solidified superalloys in the form of columnar grained gas turbine airfoils, and could eventually extend to eutectics and single crystal superalloys. Computers have played a significant role in the rapid evolution of directional solidification processing methods. Computer applications in this field can-be broken down into three major areas.
Learning Descriptor, Confidence, and Depth Estimation in Multi-view Stereo (2018)

Depth estimation from multi-view stereo images is one of the most fundamental and essential tasks in understanding a scene imaginary. In this paper, we propose a machine learning technique based on deep convolutional neural networks (CNNs) for multi-view stereo matching. The proposed method measures the matching cost to extract depth values between two-view stereo images among multi-view stereo images using a deep architecture. Moreover, we present the confidence estimation network for incorporating the cost volumes along the depth hypothesis in multiview stereo. Experiments show that our estimated depth map from multiple views shows the better performance than the other matching similarity measure on DTU dataset.
Strength-duration curve: a measure for assessing sensory deficit in peripheral neuropathy. (1984)

By using an isolated constant current stimulator producing true square-wave pulses, sensory strength-duration curves were obtained at various sites by percutaneous electrical stimulation. Strength-duration curves derived from normal groups were compared to those of patients with peripheral neuropathy. Stimulus strength at sensory threshold was shown to be a reproducible measure of sensory deficit, increasing parallel to the degree of axonal failure found by conventional methods. This may be useful as a complementary method in assessing peripheral neuropathy.
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. (1996)

We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly. Induction of passive tolerance to GAD65, through inactivation of reactive T cells before the onset of autoimmunity, prevented determinant spreading and the development of insulin-dependent diabetes mellitus (IDDM). Here, we examined whether an alternative strategy, designed to induce active tolerance via the engagement of Th2 immune responses to GAD65, before the spontaneous onset of autoimmunity, could inhibit the cascade of Th1 responses that lead to IDDM. We observed that a single intranasal administration of GAD65 peptides to 2-3-wk-old NOD mice induced high levels of IgG1 antibodies to GAD65. GAD65 peptide treated mice displayed greatly reduced IFN gamma responses and increased IL-5 responses to GAD65, confirming the diversion of the spontaneous GAD65 Th1 response toward a Th2 phenotype. Consistent with the induction of an active tolerance mechanism, splenic CD4+ (but not CD8+) T cells from GAD65 peptide-treated mice, inhibited the adoptive transfer of IDDM to NOD-scid/scid mice. This active mechanism not only inhibited the development of proliferative T cell responses to GAD65, it also limited the expansion of autoreactive T cell responses to other beta cell antigens (i.e., determinant spreading). Finally, GAD65 peptide treatment reduced insulitis and long-term IDDM incidence. Collectively, these data suggest that the nasal administration of GAD65 peptides induces a Th2 cell response that inhibits the spontaneous development of autoreactive Th1 responses and the progression of beta cell autoimmunity in NOD mice.
Alteration of the substrate range of haloalkane dehalogenase by site‐directed mutagenesis (1998)

We attempted to expand the range of chlorinated solvents degraded by Xanthobacter autotrophicus GJ10 to include trichloroethylene by the rational modification of the enzyme haloalkane dehalogenase. The amino acids Phe164, Asp170, Phe172 and Trp175 were individually replaced with alanine by site-directed mutagenesis. All substitutions produced enzymes with lower than wild type activity with 1,2-dichloroethane. The Phe164Ala and Asp170Ala mutants were 3 and 2 times more active than was the wild type enzyme in dechlorinating 1,6-dichlorohexane. The Asp170Ala mutant resembled the wild type enzyme in its relative activity against longer chain substrates. No mutant was active with trichloroethylene. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59: 520–523, 1998.
Primary pediatric intracranial neuroblastoma: A report of two cases (2018)

Neuroblastoma is the most common pediatric extracranial solid malignancy. It has a high propensity for spread, especially to the bones and lymph nodes. The involvement of central nervous system is uncommon and most of the cases are restricted to the spine. Primary intracranial neuroblastoma is extremely rare and very few cases have been described in the available literature. We report two cases of primary intracranial neuroblastoma in pediatric age group.
Integrated TaaS platform for mobile development: Architecture solutions (2013)

This paper examines the Testing-as-a-Service (TaaS) solutions in mobile development and proposes a universal TaaS platform: Cloud Testing of Mobile Systems (CTOMS). CTOMS is an integrated solution with a core infrastructure that enables the scaling of additional functionalities. The CTOMS's benefits are explained, the architecture of the system is described in detail, and technical solutions are listed based on the feasibility study that resulted in creation of the first version of CTOMS for Android development.
CRISPRi repression of nonhomologous end‐joining for enhanced genome engineering via homologous recombination in <i>Yarrowia lipolytica</i> (2017)

In many organisms of biotechnological importance precise genome editing is limited by inherently low homologous recombination (HR) efficiencies. A number of strategies exist to increase the effectiveness of this native DNA repair pathway; however, most strategies rely on permanently disabling competing repair pathways, thus reducing an organism's capacity to repair naturally occurring double strand breaks. Here, we describe a CRISPR interference (CRISPRi) system for gene repression in the oleochemical-producing yeast Yarrowia lipolytica. By using a multiplexed sgRNA targeting strategy, we demonstrate efficient repression of eight out of nine targeted genes to enhance HR. Strains with nonhomologous end-joining repressed were shown to have increased rates of HR when transformed with a linear DNA fragment with homology to a genomic locus. With multiplexed targeting of KU70 and KU80, and enhanced repression with Mxi1 fused to deactivated Cas9 (dCas9), rates of HR as high as 90% were achieved. The developed CRISPRi system enables enhanced HR in Y. lipolytica without permanent genetic knockouts and promises to be a potent tool for other metabolic engineering, synthetic biology, and functional genomics studies.
Antegrade/Retrograde Blood Cardioplegia to Ensure Cardioplegic Distribution: Operative Techniques and Objectives (1989)

This article details techniques of delivery of antegrade/retrograde blood cardioplegia to ensure its distribution to prevent ischemic damage during aortic clamping, and describes methods of using warm blood cardioplegia to "resuscitate" the heart when used to induce cardioplegia and "avoid reperfusion damage" when given just before aortic unclamping. A technique of rapid transatrial cannulation of the coronary sinus is described to permit safe, rapid, and simple use of retrograde cardioplegia and avoid right heart isolation. Theoretic objectives of these operative techniques are discussed, together with presentation of the specific methods of achieving the aforementioned goals of using blood cardioplegia for resuscitation, prevention, and avoidance of ischemic and reperfusion damage. The preliminary clinical experience with antegrade/retrograde cardioplegia is summarized, and these results have led to adoption of these techniques of blood cardioplegia as the preferred method of myocardial protection in all adult operations and in many pediatric cardiac procedures.
Transcriptome sequencing uncovers a three–long noncoding RNA signature in predicting breast cancer survival (2016)

Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. The aim of this study is to identify lncRNA signature that can predict breast cancer patient survival. RNA expression data from 1064 patients were downloaded from The Cancer Genome Atlas project. Cox regression, Kaplan-Meier, and receiver operating characteristic (ROC) analyses were performed to construct a model for predicting the overall survival (OS) of patients and evaluate it. A model consisting of three lncRNA genes (CAT104, LINC01234, and STXBP5-AS1) was identified. The Kaplan-Meier analysis and ROC curves proved that the model could predict the prognostic survival with good sensitivity and specificity in both the validation set (AUC = 0.752, 95% confidence intervals (CI): 0.651-0.854) and the microarray dataset (AUC = 0.714, 95%CI: 0.615-0.814). Further study showed the three-lncRNA signature was not only pervasive in different breast cancer stages, subtypes and age groups, but also provides more accurate prognostic information than some widely known biomarkers. The results suggested that RNA-seq transcriptome profiling provides that the three-lncRNA signature is an independent prognostic biomarker, and have clinical significance. In addition, lncRNA, miRNA, and mRNA interaction network indicated lncRNAs may intervene in breast cancer pathogenesis by binding to miR-190b, acting as competing endogenous RNAs.
CMOS image sensor with logarithmic response and self-calibrating fixed pattern noise correction (1998)

Optical CMOS sensor arrays have to cope with the problem of mismatch between individual pixels. This paper describes a CMOS camera chip with logarithmic response that has an automatic analog fixed pattern noise correction on chip. It was fabricated in an 0.8 micron process and consists of 64 X 64 active pixels. The photoreceptors show a measured response of about 100 mV per decade in light intensity and a dynamic range of more than 6 decades. Each pixel includes a capacitor to store the offset correction voltage. After applying the calibration procedure the remaining fixed pattern noise of one column has a standard deviation of 2 mV corresponding to 2 percent of a decade. The result is a system with significantly reduced pixel to pixel variations in comparison to similar uncalibrated photoreceptor arrays.
Host range of 14 mycobacteriophages in Mycobacterium ulcerans and seven other mycobacteria including Mycobacterium tuberculosis – application for identification and susceptibility testing (2005)

The host range of well-characterized mycobacteriophages, such as D29 and TM4, has been determined, together with that of more recently isolated mycobacteriophages, in Mycobacterium ulcerans, Mycobacterium tuberculosis, Mycobacterium bovis BCG, Mycobacterium avium, Mycobacterium marinum, Mycobacterium scrofulaceum, Mycobacterium fortuitum and Mycobacterium chelonae. Here, a set of virulent phages for M. ulcerans, a pathogen with a dramatic increase of incidence over the last decade, is demonstrated. In this work, a mycobacteriophage replication assay was adapted for the identification and rifampicin-susceptibility testing of M. ulcerans. Mycobacteriophages have generated a number of useful tools and enabled insights into mycobacterial genetics. With regard to the neglected pathogen M. ulcerans, the findings presented in this work allow the application of a large range of phage-based vectors and markers. The potential of phage therapy can now be evaluated for this extracellular pathogen.
Sintering of Low‐Density Glasses: II, Experimental Study (1977)

Densification rates are reported for 3 classes of porous glass materials: soot preforms made by flame hydrolysis, silica gel, and phase‐separated and leached borosilicate glass. Viscosity values obtained by fitting the densification data to the theory of Part I of the present study are in reasonable agreement with viscosity measured by beam bending using fully sintered glass of the same type.
Atherosclerosis Is an Inflammatory Disease which Lacks a Common Anti-inflammatory Therapy: How Human Genetics Can Help to This Issue. A Narrative Review (2018)

Atherosclerosis is a multifactorial disease triggered and sustained by different risk factors such as dyslipidemia, arterial hypertension, diabetes mellitus, smoke, etc. Since a couple of decades, a pivotal role for inflammation in its pathogenesis has been recognized and proved at molecular levels, and already described in many animal models. Despite all this knowledge, due to the complexity of the specific inflammatory process subtending atherosclerosis and to the fact that inflammation is also a protective response against microorganisms, no anti-inflammatory therapy has been rendered available in the therapeutic armamentarium against atherosclerosis and vascular events till 2017 when canakinumab in the first <i>ad-hoc</i> randomized clinical trial (RCT) proved for the first time that targeting specifically inflammation lowers cardiovascular (CV) events. From the genetic side, in the 90's and early 2000, several genetic markers in inflammatory pathway have been explored searching for an association with athero-thrombosis which gave seldom consistent results. Then, in the genomic era, plenty of genetic markers covering most of the genome have been analyzed at once without <i>a priori</i> information. The results coming from genome wide association studies (GWAS) have pinpointed some loci closed to inflammatory molecules consistently associated with atherosclerosis and CV consequences revamping the strict link between inflammation and atherosclerosis and suggesting some tailored target therapy. Whole-exome and whole-genome sequencing will come soon showing new and old loci associated with atherosclerosis suggesting new molecular targets or underlying which inflammatory pathway could be most attractive to target for blocking atherosclerosis even in its early stages.
Hydrogen chloride catalyzed oxygen-18 exchange between p-substituted phenyl methyl sulfoxides and water (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogen chloride catalyzed oxygen-18 exchange between p-substituted phenyl methyl sulfoxides and waterArthur Fry and Ikuo OokuniCite this: J. Org. Chem. 1971, 36, 26, 4097–4101Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/jo00825a019https://doi.org/10.1021/jo00825a019research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An overview of a compiler for mapping MATLAB programs onto FPGAs (2003)

This paper describes a behavioral synthesis tool called the MATCH compiler developed as part of the DARPA Adaptive Computing Systems program. The MATCH compiler reads in high-level descriptions of DSP applications written in MATLAB, and automatically generates synthesizable RTL models in VHDL. The RTL models can be synthesized using commercial logic synthesis tools and place and route tools onto FPGAs. By linking the two design domains of DSP and FPGA hardware design, the MATCH compiler provides DSP design teams a significant reduction in design labor and time, elimination of misinterpretations and costly design rework, automatic verification of the hardware implementation, and the ability of systems engineers and algorithm developers to perform architectural exploration in the early phases of their development cycle. The paper describes how powerful directives are used to provide high-level architectural tradeoffs for the DSP designer. The MATCH compiler has been transferred to a startup company called AccelChip which has developed a commercial version of the compiler called AccelFPGA. Experimental results are reported using AccelFPGA on a set of nine MATLAB benchmarks that are mapped onto the recent Xilinx Virtex II and Altera Stratix FPGAs. The benchmark programs range in complexity from 20 lines to 170 lines of MATLAB code and produce VHDL code ranging from 1500 to 4500 lines of code. The compilation times range from 3 seconds to 40 seconds.
COLOMBO Deliverable 2.2: Policy Definition and dynamic Policy Selection Algorithms (2014)

In chapter 2, a literature research points out a lot of differences regarding to light signals between Austria, Belgium, France, Germany, Italy, Netherlands, and the United Kingdom. Normally the street user can handle the different light signals in a safe way, but when planning light signals certain differences could be recognised. In this chapter, a common and unambiguous glossary is defined, highlighting the concepts that will be used in the rest of the document. In chapter 3, a general overview of signal control methods and a classification after Fixed Time (time dependent) Signal Control, Actuated (traffic dependent) Signal Control and Adaptive Signal Control is presented. In chapter 4, time-dependent, fixed time signal control methods are presented, and a thorough explanation of the prerequisites for designing this kind of control methods is shown In chapter 5, the coordination of arterials and networks is properly explained. While this is a special case of time-dependent control, it deserved a full chapter because coordination is very important when controlling arterial streets, mostly in urban areas. In chapter 6, traffic dependent signal control methods are presented, with a peculiar emphasis on fully traffic dependent, actuated signal control. Chapter 7 introduces adaptive signal control systems, providing also some historical background on their development and adoption in Europe. The different approaches and results of several methods used all over the world are presented. Chapter 8 presents the traffic control method designed for the COLOMBO project, how it is split into a macroscopic level adaptive control system and into several microscopic level policies. Preliminary results on the usage of these policies compared to other policies already implemented into the simulation environment are reported.