gebhart/patrepeval huggingface dataset:
Evidence for S-Adenosyl-<scp>L</scp>-Methionine (SAM-e) for the Treatment of Major Depressive Disorder (2009)

Despite the increasingly large array of antidepressants available to treat major depressive disorder, patients continue to experience relatively modest response and remission rates. In addition, patients may experience adverse side effects from pharmacotherapy that not only hinder treatment compliance and adherence but, in some cases, may also contribute to increased disability, patient suffering, morbidity, and mortality. In order to enhance treatment efficacy and tolerability, patients and clinicians have become increasingly interested in nonpharmaceutical supplements for treating depression. One of the best-studied of these supplements is S-adenosyl-L-methionine (SAM-e), a naturally occurring molecule present in all living cells and a major methyl group donor in the human body. Controlled trials have found SAM-e to be more efficacious than placebo and equal in efficacy to the tricyclic antidepressants for treating major depressive disorder (MDD) when administered parenterally (either intravenously or intramuscularly). Less evidence supports the use of oral SAM-e, although some trials have demonstrated its efficacy as well. In addition, there is a paucity of evidence examining whether oral forms of SAM-e can be safe, well tolerated, and efficacious when used as adjunctive treatment for antidepressant nonresponders with MDD. Although preliminary data suggest SAM-e may be useful as an adjunctive therapy to antidepressants, controlled studies are needed to confirm or refute these preliminary findings.
Effect of nucleophilicity and leaving group ability on the SN2 reactions of amines with (acyloxy)alkyl .alpha.-halides: a product distribution study (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of nucleophilicity and leaving group ability on the SN2 reactions of amines with (acyloxy)alkyl .alpha.-halides: a product distribution studyKenneth B. Sloan and Suzanne A. M. KochCite this: J. Org. Chem. 1983, 48, 5, 635–640Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://doi.org/10.1021/jo00153a002Request reuse permissionsArticle Views1547Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (860 KB) Get e-Alertsclose Get e-Alerts
Characterization and application of a monoclonal antibody with dual specificity for hemoglobins S and C. (1988)

In an effort to develop a rapid screening immunoassay for the presence of hemoglobin S (Hb S) in cord blood, we have produced a hybridoma (beta s-1) secreting a monoclonal antibody (MAb) with strict specificity for Hb S over hemoglobin (Hb A). A reactivity was observed for hemoglobin C (Hb C) that was weaker than that for Hb S but still greater than 10(3) times greater than that seen for Hb A. Application of this antibody in a dot blot assay provided for a rapid (50-minute) single-step confirmatory test for Hb S, Hb C, or both in cord blood hemolysates. The sensitivity of the test would allow for mass screening of cord blood hemolysates (40 mg total hemoglobin per milliliter) and detection of Hb S, Hb C, or both at concentrations greater than or equal to 1%.
iGrace – Emotional Computational Model for EmI Companion Robot. (2009)

Advances in Human-Robot Interaction 52 emotional companion. As the use of robots in a hospital environment remains limited, we have decided to opt for simplicity in the robotic architecture, thus in the emotional expression as well. The EmotiRob project, a component of the MAPH project, aims at maintaining nonverbal interaction with children between 4 and 8 years of age. As has been shown in the synopsis (see Figure
Use of isocyanate production waste in the preparation of improved waterproofing bitumen (2003)

Abstract Waste residue generated during the production of toluene diisocyanate was used as a modifier in making improved waterproofing bitumen. The waste particles were surface‐modified with stearic acid. Various bitumen blends based on untreated particles, surface‐treated particles, and a combination of an SBS elastomer and waste particles were prepared. The optimized blends were subjected to evaluate their response against temperature and frequency sweeps. It was observed that improvement of the softening point and reduction in penetration could be correlated with the blend morphology in terms of the compatibility between the waste particles and the bitumen. The increased glass transition temperature and satisfactory phase miscibility in the modified bitumen observed in MDSC and DMA traces supported these findings. The coefficient of linear thermal expansion of the modified bitumen was found to be 1.21 × 10 −4 /°C. The rheological studies revealed that time‐dependent properties of the modified bitumen were better in terms of its stiffness and elasticity than that of neat bitumen. The applicability of the Williams–Landel–Ferry (WLF) equation confirms the superior temperature‐dependent response of the modified systems over the control. It was noticed that stearate‐treated waste‐modified bitumen gives the best results in terms of a high complex modulus and a low phase angle. The newly formulated bituminous blend based on stearate‐treated waste meets the requirement of existing standard specifications for waterproofing felt. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 1365–1377, 2003
Transmission and Scanning Electron Microscopy of Peanut (Arachis hypogaea L. CV. Florigiant) Cotyledon After Roasting (1990)

Changes in the microstructure of peanut (Arachis~ L. cv. Florigiant) cotyledon after roasting at a temperature of 160°C for 16 minutes were investigated with transmission and scanning electron microscopy. Thermal modifications were documented with photomicrographs of t he cytoplasmic network , protein bodies, starch grains and cell-to-cell junctions after oven roasting. These thermal modifications include disruption of the cytoplasmic network, distension of protein bodies, decreased stain affinity of starch grains , and disintegration of middle lamellae in some cell-t o-cell junctions.
Carcinoma‐associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF‐2/FGFR‐2 axis (2008)

The mechanisms by which mammary carcinomas acquire hormone independence are still unknown. To study the role of cancer-associated fibroblasts (CAF) in the acquisition of hormone-independence we used a hormone-dependent (HD) mouse mammary tumor and its hormone-independent (HI) variant, which grows in vivo without hormone supply. HI tumors express higher levels of FGFR-2 than HD tumors. In spite of their in vivo differences, both tumors have the same hormone requirement in primary cultures. We demonstrated that CAF from HI tumors (CAF-HI) growing in vitro, express higher levels of FGF-2 than HD counterparts (CAF-HD). FGF-2 activated the progesterone receptors (PR) in the tumor cells, thus increasing cell proliferation in both HI and HD tumors. CAF-HI induced a higher proliferative rate on the tumor cells and in PR activation than CAF-HD. The blockage of FGF-2 in the co-cultures or the genetic or pharmacological inhibition of FGFR-2 inhibited PR activation and tumor cell proliferation. Moreover, in vivo, the FGFR inhibitor decreased C4-HI tumor growth, whereas FGF-2 was able to stimulate C4-HD tumor growth as MPA. T47D human breast cancer cells were also stimulated by progestins, FGF-2 or CAF-HI, and this stimulation was abrogated by antiprogestins, suggesting that the murine C4-HI cells respond as the human T47D cells. In summary, this is the first study reporting differences between CAF from HD and HI tumors suggesting that CAF-HI actively participate in driving HI tumor growth.
ChemInform Abstract: ISOPRENE FUNCTIONALIZATION. E/Z‐ISOMERISM OF 1‐SULFONYL SUBSTITUTED 2‐METHYLBUTADIENES (1980)

Abstract Durch Umsetzung der Sulfonylchloride (I) mit Isopren (II) werden die isomeren Chlorsulfone (III), (IV), (V) erhalten, deren Dehydrochlorierung zu den E‐Butadienylsulfonen (VI) bzw. (VIII) bzw. zu Gemischen von (VI) mit ihren Z‐Iso‐ /′ f meren (VII) führt.
Carburants et combustibles liquides (1988)

1 Généralités 1.1 Définitions et classifications 1.2 Place des carburants et combustibles dans la consommationénergétique 1.3 Caractéristiques des carburants et combustibles. Spécifications etqualités réelles 2 Carburants pour moteurs à allumage commandé 2.1 Propriétés physiques
Interception of some direct‐acting mutagens by ergothioneine (1987)

Ergothioneine, a novel imidazole sulfhydryl/thione compound formed in millimolar amounts by fungi, is a potentially important defense against electrophiles and free radicals. Protection may well occur both in organisms that synthesize ergothioneine and in animals including man that ingest and store ergothioneine in red blood cells, the liver, seminal fluid, and central nervous system. Ergothioneine blocks the mutagenicity for Salmonella strain TA1950 (hisG46 uvrB) of the nitrosation products of spermidine to an extent that is approximately proportional to the ergothioneine concentration. Ergothioneine also alleviates mutagenicity of cumene and t-butyl hydroperoxides but does not react with N-methyl-N'nitro-N-nitrosoguanidine as does the cysteinyl sulfhydryl compound, glutathione.
Implementation of Soft Location on mobile devices (2002)

This paper highlights issues of improved concepts for location information. Starting with a description of the soft location representation the paper presents a tool to easily combine different sources of location information from heterogeneous sensor data. It shows a first implementation of the described system. It also considers the integration aspects of the system on programmable mobile devices and presents an extension to combine location sensors that are measured at different points in time.
A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer (2018)

Clinicaltrials.gov: NCT02532114.
[New medical treatment for viral conjunctivitis]. (2005)

Around one million people in Japan are suffering from adenoviral conjunctivitis every year and it is recognized as one of the major pathogens of nosocomial infection. Several complications, such as corneal erosion and conjunctival pseudomembrane, are observed in some of the cases and corneal sube- pithelial opacity may bring visual impairment. Moreover, no specific anti-adenoviral agent has been discovered and an effective treatment has not been established for adenoviral infection. We have researched new medical treatment for viral conjunctivitis based on recent findings in adenoviral conjunctivitis. Firstly, anti-adenoviral activity was evaluated in vitro in agents which could possibly act as anti-adenoviral drugs. Twelve candidates, such as zalcitabin, interferon beta, etc., were selected among antiviral drugs, adenoviral receptor inhibitors, natural products and anti-inflammatory drugs. Remarkable anti-adenoviral effect was observed in zalcitabin, sanilbudine, interferon beta and anti-osteopontin peptide. Two anti-human immunodeficiency virus (HIV) drugs with anti-adenoviral activity, zalcitabin and sanilbudine, are nucleoside reverse transcriptase inhibitors, but, in contrast, non-nucleoside reverse transcriptase inhibitors and protease inhibitors were ineffective against adenovirus. Interferon beta and anti-osteopontin peptide displayed anti-adenoviral effects by absorption inhibition. Secondly, side effects caused by possible anti-adenoviral eye drops, including cidofovir whose development as eye drops against eyeball and ocular adnexa had been suspended, were analyzed in a white rabbit model. In animals given cidofovir locally, significant narrowing of lacrimal canaliculus, redness of eyelid and conjunctival injection was observed, but obstruction of the lacrimal duct was not found. Although zalcitabin and sanilbudine eye drops induced eyelid redness, no change was observed in the lacrimal route and conjunctiva. In animals treated by cidofovir, inflammation histologically suggesting mainly allergic change was observed. These results indicate that these four drugs are possible candidate for safe eye drops against adenoviral conjunctivitis. These four agents are divided into two categories, inhibitors of adenoviral replication, zalcitabin and sanilbudine; and suppressors of adenoviral infection, interferon beta and anti-osteopontin peptide. It is expected that eye drops for specific treatment of adenoviral conjunctivitis are going to be available in the near future following investigation of therapeutic effect in adenoviral infected animals and clinical trials in humans.
Efficient fiber-optical interface for nanophotonic devices (2015)

We demonstrate a method for efficient coupling of guided light from a single-mode optical fiber to nanophotonic devices. Our approach makes use of single-sided conical tapered optical fibers that are evanescently coupled over the last ~10 μm to a nanophotonic waveguide. By means of adiabatic mode transfer using a properly chosen taper, single-mode fiber-waveguide coupling efficiencies as high as 97(1)% are achieved. Efficient coupling is obtained for a wide range of device geometries, which are either singly clamped on a chip or attached to the fiber, demonstrating a promising approach for integrated nanophotonic circuits, and quantum optical and nanoscale sensing applications.
A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503) (2013)

RO4929097 in combination with cediranib is generally well tolerated at the DLs tested. Preliminary evidence of antitumour efficacy with prolonged disease stabilisation in some patients with progressive malignancies warrants further clinical investigation of this treatment strategy.
AEROGELS: APPLICATIONS, STRUCTURE, AND HEAT TRANSFER PHENOMENA (1995)

This chapter provides an interdisciplinary review of a fascinating porous material known as aerogel. It begins with a description of the production techniques and the historical development. This is followed by a review of a wide-range of potential applications, with much emphasis given to use of aerogels as catalysts and thermal insulators. Next, the methods currently used for studying the intriguing microstructure and their results are presented. Finally, due to the tremendous potential of aerogels as thermal insulators, the heat transfer mechanisms, which are strongly influenced by the nanoporous microstructure, are discussed in detail. While several reviews of ultrafine structures, and even aerogels, are available in the literature, this is the first such work directed at the mechanical engineering community.
The present role of indocyanine green angiography in ophthalmology (1999)

Recent developments in the clinical application of indocyanine green angiography have mainly concerned refining its role as an adjunct to fluorescein angiography in detecting and guiding the treatment of choroidal neovascularization. We now have a better understanding of the different patterns of abnormal hyperfluorescence seen with indocyanine green angiography in eyes with both wet and dry forms of macular degeneration. In exudative cases, the success rate of laser treatment guided by indocyanine green angiographic findings can vary considerably, and it is now known which angiographic presentations are not as likely to benefit. In dry macular degeneration, indocyanine green angiography appears to add clinically useful information, such as helping to identify plaques in fellow eyes with choroidal neovasculrization or watershed zones that may be predictive of future exudative transformation. In certain circumstances, indocyanine green angiography can be valuable in detecting choroidal neovascularization in other macular diseases or in helping to diagnose other choroidal conditions, especially when the clinical presentation is atypical, such as central serous chorioretinopathy in elderly patients.
Surface Morphology and Crystallographic Orientation of Electrodeposited Gold Films (2002)

The crystallographic structure and surface morphology of Au films electrodeposited from two different baths, a cyanide bath and a sulfite bath, were studied by using SEM and XRD. The surface morphology and crystallographic orientation of Au films deposited on a Ni-P amorphous substrate were found to vary according to the electrodeposition bath composition. For Au films deposited in a cyanide bath, the {111} plane appeared to be a preferential orientation, independent of deposition conditions, such as current density, bath temperature and film thickness. However, Au films deposited in a sulfite bath, the preferential orientation varied with deposition conditions.
A randomized controlled trial of citalopram in the treatment of fibromyalgia (1995)

Amitriptyline and cyclobenzaprine have shown some efficacy in treatment of the generalised pain syndrome, fibromyalgia. The aim of this study was to examine the efficacy of antidepressant dosages of the serotonin re-uptake inhibitor citalopram in fibromyalgia. In a double-blind, placebo-controlled study 22 patients with fibromyalgia were randomized to treatment with citalopram for 4 weeks at a dosage of 20 mg a day while 21 received placebo. After 4 weeks the dosage was increased to 40 mg for a further 4 weeks if the subjects did not report a marked improvement. After the end of treatment (8 weeks) no changes were observed in self-assessment of symptoms, physician's global assessment, tender points, Beck depression score or voluntary muscle strength and no differences were observed between the groups. Citalopram showed no demonstrable effect on this group of pain patients. The strength of the study was sufficient to exclude an effect of citalopram of more than 1 steps of 10 on the categoric scales for pain, fatigue and general condition (95% confidence limit), which indicates that the sample size was sufficiently large.
“The Knee in Sports” (1970)

This book fills an essential gap in textbooks of whole body human physiology, with useful experiments that work, rather than obscure techniques suited only to a sophisticated research laboratory. I am recommending this book to B.Ed., physical education students as the basis of their practical physiology course.
The Use of the Mother Tongue and the Teaching of Translation<sup>1</sup> (1970)

The Use of the Mother Tongue and the Teaching of Translation1 Get access J. F. GREEN J. F. GREEN Search for other works by this author on: Oxford Academic Google Scholar ELT Journal, Volume XXIV, Issue 3, May 1970, Pages 217–223, https://doi.org/10.1093/elt/XXIV.3.217 Published: 01 May 1970
Population Growth of Lettuce, Nasonovia ribisnigris, on Resistant Butter and Head Lettuce Cultivars (2002)

Studies to examine lettuce aphid population growth on resistant head and butter lettuce cultivars were conducted in small filed plots at the Yuma Agricultural Center. By artificially infesting plants on several lettuce plantings during the spring, the influence of the resistant lettuce plants were evaluated for their capability of preventing lettuce aphid populations from colonizing plants. Results of five field trials showed that several varieties of head and butter lettuce have been developed that almost completely prevent lettuce aphids from surviving and reproducing on plants during the spring. Although the cultivars tested did not posses marketable characteristic for harvests, they do provide germplasm for breeding new varieties suited for desert production. In addition, these studies also support conclusions drawn from the past several seasons that suggest lettuce aphid population growth is greatest when ambient temperatures average between 65-70 °F.
13C NMR Experiments and Methods used to Investigate Amine-CO2-H2O Systems (2013)

By using 13C Nuclear Magnetic Resonance (NMR) spectroscopy, direct qualitative and quantitative information on the species formed during the absorption and desorption of CO2 in aqueous amine solvents can be acquired. In this paper, an overview of the state of the art of 13C NMR studies performed on amine-CO2-H2O system, with a specific focus on the methods used to perform quantitative analyses, is presented. It is concluded that, for possible improvements of the efficiency of cyclic CO2 capture processes, NMR spectroscopy gives important contributions in investigating the chemical reactions occurring in amine-CO2-H2O systems.
A Zigbee-based wireless wearable electronic nose using flexible printed sensor array (2013)

A wearable electronic nose (e-nose) has been developed by integrating a low cost chemical sensor array with a wireless communication for applications in healthcare. Its sensing unit was fabricated by a fully inkjet-printing technique, comprising eight different sensor elements manufactured by varying printing patterns and sensing materials. These sensors have shown response to a wide variety of complex odors. A wearable e-nose prototype using Zigbee wireless technology was designed as a compact armband for monitoring the axillary odor released from human body. Preliminary results based on principal component analysis (PCA) could classify different odors released from the human body upon various activities.
Saturation intensity and time response of InGaAs-InGaP MQW optical modulators (1995)

We report modulation saturation and time response measurements on InGaAs-InGaP MQW modulators. The measurements yield a saturation intensity of (3.7/spl plusmn/0.1) kW/cm/sup 2/ for a 0-10 V swing and switching times between 10 and 90 ns, depending on the bias voltage and incident light intensity. The observed dependence indicates that field screening due to carrier build-up is the dominant physical mechanism determining both the speed and the saturation intensity. This conclusion is supported by results of theoretical calculations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells (2010)

The p53 tumor suppressor gene is inactivated by point mutation in a large fraction of human tumors, allowing evasion of apoptosis and tumor progression. p53 mutation is often associated with increased resistance to therapy. Pharmacological reactivation of mutant p53 is an attractive therapeutic strategy. We previously identified p53 reactivation and induction of massive apoptosis, a low-molecular weight compound that suppresses the growth of cancer cells in a mutant p53-dependent manner. Here, we report the identification and characterization of an extract from the terrestrial plant Brachylaena ramiflora (Asteraceae) that preferentially induces apoptosis in human tumor cells expressing mutant p53. Further analysis of this extract and identification of active compounds may provide novel structural scaffolds for the development of mutant p53-targeting anticancer drugs.