gebhart/patrepeval huggingface dataset:
Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate. (1993)

The expression of NGFIA (also known as egr1, zif268, TIS8, krox24, and d2) is rapidly and transiently increased by nerve growth factor (NGF) in PC12 cells. The 5'-region of this gene includes four serum response elements (SREs), a cAMP-like response element, an AP1-like response element, and an SP1-binding site. From deletion analysis of chloramphenicol acetyltransferase reporter constructs, we have established that the first 106 basepairs 5' of the transcriptional start site are sufficient for induction of NGFIA by NGF in PC12 cells; deletion beyond this point results in dramatically reduced induction of the gene. Using defined mutations in the NGFIA promoter and NGFIA-thymidine kinase hybrid promoters, we have defined three elements (SRE1, SRE2, and AP1-like) in the first 106 basepairs of upstream DNA, each of which contributes to induction of NGFIA by NGF. Cooperation by two of these elements (i.e. the two SREs or one SRE and the AP1-like element) is sufficient to confer transcriptional induction by NGF, but the combination of all three elements increased induction by NGF more effectively than a pair of elements. This suggests that the response of NGFIA to NGF is mediated by a cis-acting sequence that is composed of at least three distinct elements. An oligonucleotide composed of SRE1 and SRE2 that can confer the ability for NGF induction to heterologous promoter constructs complexes with proteins in PC12 cell nuclear extracts, but the protein-DNA complexes do not appear to be altered by NGF treatment, as measured by DNA mobility shift assays. We have also established that the regulatory region of NGFIA that mediates NGF induction also mediates the induction by serum and phorbol 12-myristate 13-acetate, suggesting that multiple signal transduction pathways must converge on these sequences to regulate the expression of this gene.
NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma (2009)

NFAT2 and 4 are expressed in human metastatic melanoma cell lines and are activated by oncogenic BRAF(V600E) via MEK/ERK signalling. NFAT is an important upstream regulator of COX-2 in metastatic melanoma. Furthermore, as the BRAF/MEK/ERK pathway is hyperactive in other malignancies and MEK/ERK are also activated by oncogenic RAS in 30% of all human cancers, the potential to exploit NFAT signalling for therapeutic benefit warrants further investigation.
Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy (2013)

This article reviews the latest developments in understanding the pathogenesis, detection and treatment of small intestinal damage and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs). With improvements in the detection of NSAID-induced damage in the small intestine, it is now clear that this injury and the associated bleeding occurs more frequently than that occurring in the stomach and duodenum, and can also be regarded as more dangerous. However, there are no proven-effective therapies for NSAID-enteropathy, and detection remains a challenge, particularly because of the poor correlation between tissue injury and symptoms. Moreover, recent studies suggest that commonly used drugs for protecting the upper gastrointestinal tract (i.e., proton pump inhibitors) can significantly worsen NSAID-induced damage in the small intestine. The pathogenesis of NSAID-enteropathy is complex, but studies in animal models are shedding light on the key factors that contribute to ulceration and bleeding, and are providing clues to the development of effective therapies and prevention strategies. Novel NSAIDs that do not cause small intestinal damage in animal models offer hope for a solution to this serious adverse effect of one of the most widely used classes of drugs.
Benefits of using virtual energy storage system for power system frequency response (2016)

• The VESS is proposed to facilitate the conversion to a low carbon power system. • A VESS consisting of flexible demand and conventional FESS is firstly formulated. • The VESS is controlled to provide fast firm amount of dynamic frequency response. • The VESS provides frequency response at a lower cost compared with only using FESS. • The VESS reduces the costly spinning reserve capacity from fossil-fuel generators. This paper forms a Virtual Energy Storage System (VESS) and validates that VESS is an innovative and cost-effective way to provide the function of conventional Energy Storage Systems (ESSs) through the utilization of the present network assets represented by the flexible demand. The VESS is a solution to convert to a low carbon power system and in this paper, is modelled to store and release energy in response to regulation signals by coordinating the Demand Response (DR) from domestic refrigerators in a city and the response from conventional Flywheel Energy Storage Systems (FESSs). The coordination aims to mitigate the impact of uncertainties of DR and to reduce the capacity of the costly FESS. The VESS is integrated with the power system to provide the frequency response service, which contributes to the reduction of carbon emissions through the replacement of spinning reserve capacity of fossil-fuel generators. Case studies were carried out to validate and quantify the capability of VESS to vary the stored energy in response to grid frequency. Economic benefits of using VESS for frequency response services were estimated.
Signal Transduction by Intramitochondrial Ca2+ in Mammalian Energy Metabolism (1994)

Hormones and other extracellular agents often stimulate energy-requiring processes such as muscle contraction and secretion through increases in cytosolic calcium. To preserve energy homeostasis, ATP formation must also be stimulated. One important mechanism involves increases in mitochondrial calcium and activation of key steps in the process of oxidative phosphorylation.
Activities for teaching positive psychology: A guide for instructors. (2012)

Positive psychology is a rapidly expanding area of study that is of great interest to students at the graduate, undergraduate, and high school levels. But the field is so broad that teachers who want to cover all the bases when designing a positive psychology course may have difficulty locating and selecting materials. Activities for Teaching Positive Psychology addresses this problem by presenting a comprehensive set of fun, interactive classroom activities devised by contributors who are experienced teachers as well as leading scholars in their areas. Chapters cover all the topics typically included in existing positive psychology textbooks, emphasising the hands-on experience that makes positive psychology courses so powerful. Extensive reading lists point interested readers towards a fuller understanding of the topics. The book is a rich source of ideas for all teachers of psychology, from novice to experienced instructors.
ANTIBACTERIAL AND ANTIFUNGAL TERPENES FROM Pilgerodendron uviferum (D. DON) FLORIN (2004)

Ten sesquiterpenes (a-cubebene, copaene, a-caryophyllene, caryophyllene-4,5-epoxide, d-cadinene, cubenol, epicubenol, torreyol, humulene-1,2-epoxide, 15-copaenol) and six diterpenes (hinokione, hinokiol, ferruginol, 6,7-dehydroferruginol, totarol, sugiol) were isolated and identified from Pilgerodendron uviferum (D. Don) Florin wood and bark. The molecular structures were elucidated by spectroscopic methods. Twelve pure compounds were tested for antimicrobial activity against standard bacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aureginosa, Streptococcus pyogenes) and fungal strains (Ophiostoma piliferum, Rhizoctonia solani, Phragmidium violaceum, Fusarium graminearum, Pythium irregulare, Botrytis cinerea, Schizophyllum commune), as were crude total extracts, n-hexane, dichloromethane, and ethyl acetate partial extracts. All the compounds tested exhibited biological activity, with the most active being ferruginol, hinokiol, 15-copaenol, cubenol, torreyol, and n-hexane wood extracts and ethyl acetate bark extract
Dietary effects on human gut microbiome diversity (2014)

The human gut harbours diverse and abundant microbes, forming a complex ecological system that interacts with host and environmental factors. In this article, we summarise recent advances in microbiome studies across both Western and non-Western populations, either in cross-sectional or longitudinal surveys, and over various age groups, revealing a considerable diversity and variability in the human gut microbiome. Of all the exogenous factors affecting gut microbiome, a long-term diet appears to have the largest effect to date. Recent research on the effects of dietary interventions has shown that the gut microbiome can change dramatically with diet; however, the gut microbiome is generally resilient, and short-term dietary intervention is not typically successful in treating obesity and malnutrition. Understanding the dynamics of the gut microbiome under different conditions will help us diagnose and treat many diseases that are now known to be associated with microbial communities.
MeCP2 and Rett syndrome: reversibility and potential avenues for therapy (2011)

Mutations in the X-linked gene MECP2 (methyl CpG-binding protein 2) are the primary cause of the neurodevelopmental disorder RTT (Rett syndrome), and are also implicated in other neurological conditions. The expression product of this gene, MeCP2, is a widely expressed nuclear protein, especially abundant in mature neurons of the CNS (central nervous system). The major recognized consequences of MECP2 mutation occur in the CNS, but there is growing awareness of peripheral effects contributing to the full RTT phenotype. MeCP2 is classically considered to act as a DNA methylation-dependent transcriptional repressor, but may have additional roles in regulating gene expression and chromatin structure. Knocking out Mecp2 function in mice recapitulates many of the overt neurological features seen in RTT patients, and the characteristic postnatally delayed onset of symptoms is accompanied by aberrant neuronal morphology and deficits in synaptic physiology. Evidence that reactivation of endogenous Mecp2 in mutant mice, even at adult stages, can reverse aspects of RTT-like pathology and result in apparently functionally mature neurons has provided renewed hope for patients, but has also provoked discussion about traditional boundaries between neurodevelopmental disorders and those involving dysfunction at later stages. In the present paper we review the neurobiology of MeCP2 and consider the various genetic (including gene therapy), pharmacological and environmental interventions that have been, and could be, developed to attempt phenotypic rescue in RTT. Such approaches are already providing valuable insights into the potential tractability of RTT and related conditions, and are useful pointers for the development of future therapeutic strategies.
Effect of nitrogen to niobium atomic ratio on superconducting transition temperature of δ-NbN x powders (2010)

Powders of cubic niobium nitride δ-NbN x with a particle size of below 20 μm were prepared by reactive diffusion at T = 1455−1475°C under nitrogen pressures of P 1(N2) = 0.1−3 MPa and P 2(N2) = 25 MPa. For these powders, the values of the stoichiometric coefficient x, lattice parameter a, and the superconducting transition temperature Tc were measured and the a(x), T c(x) and T c(a) functions were analyzed. The T c values were found to linearly grow with increasing a (decreasing structure imperfection). A maximum value of T c (15.8 K) corresponded to a maximum value of a (4.3934 Å). Maximain the a(x) and T c(x) curves were found to correspond to a slightly substoichiometric nitride with x = 0.98. Having synthesized cubic niobium nitrides with 0.892 < x < 1.062, we managed to measure the dependences of a and T c on x all over the almost entire homogeneity range for δ-NbN x . Our a(x) and T c(a) functions were found to reasonably agree with those previously reported for SHS-produced δ-NbN x powders.
Data flow processor chip for image processing (1985)

An Image Pipelined Processor (ImPP) with high-speed processing capability has been developed utilizing a data-flow architecture strongly emphasizing pipeline processing technique. Moreover, a ring-shaped ImPP array forms a multiprocessor system by itself for higher processing performance. Pipeline processing is especially suitable for operations on streams (sequences of data). Most image processing includes these operations. The ImPP is composed of ten pipeline modules. These are connected with each other in pipeline manner, that is, a one-directional bus is mainly used between two modules for transmitting a token composed of data value and several control signals. All modules can be individually designed in parallel only with the token information. This hierarchical design approach contributes to easier chip development by using CAD systems. The ImPP is a 6.96 mm × 6.99 mm single die, containing over 115 000 transistors with advanced 1.75-µm NMOS technology, as one data-flow processor chip. It operates at 10-MHz clock rate and takes 200 ns for each pipeline stage. To make the application program development convenient, an ImPP assembler has also been developed. Using this assembler, several image processing programs have been prepared and simulated. The ImPP architecture and its processing capability are discussed based on this simulation result.
ATM foundation for broadband networks (1995)

This guide explains the role of asynchronous transfer mode (ATM) in modern data, voice and video networks. Non-theoretical in approach, the focus is on how ATM protocols operate in both local area and wide area networks. Topics covered include the architecture of ATM networks, broadband ISDN, the ATM adaptation layer which serves as the interface between user applications and the ATM cell-based operations, analysis of ATM switching elements, traffic management and SONET.
Cystatin C: A New Renal Marker and Its Potential Use in Small Animal Medicine (2014)

The occurrence of chronic kidney disease is underestimated in both human and veterinary medicine. Glomerular filtration rate (GFR) is considered the gold standard for evaluating kidney function. However, GFR assessment is time-consuming and labor-intensive and therefore not routinely used in practice. The commonly used indirect GFR markers, serum creatinine (sCr) and urea, are not sufficiently sensitive or specific to detect early renal dysfunction. Serum cystatin C (sCysC), a proteinase inhibitor, has most of the properties required for an endogenous GFR marker. In human medicine, numerous studies have evaluated its potential use as a GFR marker in several populations. In veterinary medicine, this marker is gaining interest. The measurement is easy, which makes it an interesting parameter for clinical use. This review summarizes current knowledge about cystatin C (CysC) in humans, dogs, and cats, including its history, assays, relationship with GFR, and biological and clinical variations in both human and veterinary medicine.
Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors (2008)

Tnk1/Kos1 is a non-receptor protein tyrosine kinase implicated in negatively regulating cell growth in a mechanism requiring its intrinsic catalytic activity. Tnk1/Kos1 null mice were created by homologous recombination by deleting the catalytic domain. Both Tnk1(+/-) and Tnk1(-/-) mice develop spontaneous tumors, including lymphomas and carcinomas, at high rates [27% (14 of 52) and 43% (12 of 28), respectively]. Tnk1/Kos1 expression is silenced in tumors that develop in Tnk1(+/-) mice but not in adjacent uninvolved tissue, and silencing occurs in association with Tnk1 promoter hypermethylation. Tissues and murine embryonic fibroblasts derived from Tnk1/Kos1-null mice exhibit proportionally higher levels of basal and epidermal growth factor-stimulated Ras activation that results from increased Ras-guanine exchange factor (GEF) activity. Mechanistically, Tnk1/Kos1 can directly tyrosine phosphorylate growth factor receptor binding protein 2 (Grb2), which promotes disruption of the Grb2-Sos1 complex that mediates growth factor-induced Ras activation, providing dynamic regulation of Ras GEF activity with suppression of Ras. Thus, Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity.
Disruption of<i>PPT2</i>in mice causes an unusual lysosomal storage disorder with neurovisceral features (2003)

The palmitoyl protein thioesterase-2 (PPT2) gene encodes a lysosomal thioesterase homologous to PPT1, which is the enzyme defective in the human disorder called infantile neuronal ceroid lipofuscinosis. In this article, we report that PPT2 deficiency in mice causes an unusual form of neuronal ceroid lipofuscinosis with striking visceral manifestations. All PPT2-deficient mice displayed a neurodegenerative phenotype with spasticity and ataxia by 15 mo. The bone marrow was infiltrated by brightly autofluorescent macrophages and multinucleated giant cells, but interestingly, the macrophages did not have the typical appearance of foam cells commonly associated with other lysosomal storage diseases. Marked splenomegaly caused by extramedullary hematopoiesis was observed. The pancreas was grossly orange to brown as a result of massive storage of lipofuscin pigments in the exocrine (but not islet) cells. Electron microscopy showed that the storage material consisted of multilamellar membrane profiles ("zebra bodies"). In summary, PPT2 deficiency in mice manifests as a neurodegenerative disorder with visceral features. Although PPT2 deficiency has not been described in humans, manifestations would be predicted to include neurodegeneration with bone marrow histiocytosis, visceromegaly, brown pancreas, and linkage to chromosome 6p21.3 in affected families.
Improved Survival of Island Flaps after Prolonged Ischemia by Perfusion with Superoxide Dismutase (1986)

Perfusion of rat groin flaps after 10 and 11 hours of complete ischemia with superoxide dismutase, an oxygen free-radical scavenger, significantly improved the survival of these flaps. This finding provides further evidence for the important role that oxygen-derived free radicals play in ischemic injury. The study also demonstrates that while restoration of blood supply alone is not enough to ensure tissue survival after prolonged ischemia, chemical agents can be utilized to achieve viable flaps beyond what was believed to be "a point of no return".
Differential Sensing of Zn(II) and Cu(II) via Two Independent Mechanisms (2012)

Selective reduction of an anthracenone-quinoline imine derivative, 2, using 1.0 equiv of NaBH(4) in 95% ethanol affords the corresponding anthracen-9-ol derivative, 3, as confirmed by (1)H NMR, (13)C NMR, ESI-MS, FTIR, and elemental analysis results. UV-vis and fluorescence data reveal dramatic spectroscopic changes in the presence of Zn(II) and Cu(II). Zinc(II) coordination induces a 1,5-prototropic shift resulting in anthracene fluorophore formation via an imine-enamine tautomerization pathway. Copper(II) induces a colorimetric change from pale yellow to orange-red and results in imine hydrolysis in the presence of water. Spectroscopic investigations of metal ion response, selectivity, stoichiometry, and competition studies all suggest the proposed mechanisms. ESI-MS analysis, FTIR, and single-crystal XRD further support the hydrolysis phenomenon. This is a rare case of a single sensor that can be used either as a chemosensor (reversibly in the case of Zn(II)) or as a chemodosimeter (irreversibly in the case of Cu(II)); however, the imine must contain a coordinating Lewis base, such as quinoline, to be active for Cu(II).
Nuclear Imaging in Oncology (1985)

An overview of various imaging studies for cancers in different organ systems, this volume also correlates and compares the diagnostic accuracy of these various radiologic imaging modalities. An introduction presents the basic principles of oncology and nuclear medicine and reviews the available nuclear medicine imaging procedures with specific protocols. The applications of specific procedures are divided by chapters into tumors of individual systems.
The down-regulation of alpha-interferon receptors in human lymphoblastoid cells: relation to cellular responsiveness to the antiproliferative action of alpha-interferon. (1990)

Human lymphoblastoid cell lines (Daudi, Daudi subclones, Raji and MOLT-4) were compared for sensitivity to the antiproliferative action of alpha-interferon (IFN-alpha) and down-regulation of IFN-alpha receptors. IFN-sensitive and IFN-resistant cell lines have similar numbers (2-4000/cell) of high affinity (20-75 pM) IFN-alpha receptors. Treatment of IFN-sensitive cells with low concentrations (3-10 pM) of IFN-alpha results in low receptor occupancy and nearly complete (greater than 95%) down-regulation of cell surface IFN-alpha receptors within 5 h. Treatment of resistant cells with higher IFN concentrations (30 pM) only results in partial (approximately 60%) receptor down-regulation that is directly related to receptor occupancy. Receptor-receptor interactions, induced by IFN-alpha binding, may account for the enhanced down-regulation of IFN-alpha receptors in IFN-sensitive cells. Such interactions apparently do not occur in IFN-resistant lymphoblastoid cell lines.
<title>Wavefront Sensors And Deformable Mirrors For Visible Wavelengths</title> (1980)

A review of the present technology status of wavefront sensors and deformable mirrors is presented. As components in adaptive optics systems these elements have been developed for specific requirements. Future applications will require advanced capabilities for visible wavelength operation. Some forecasts of these requirements are provided.
Who Sits Where? Infrastructure-Free In-Vehicle Cooperative Positioning via Smartphones (2014)

Seat-level positioning of a smartphone in a vehicle can provide a fine-grained context for many interesting in-vehicle applications, including driver distraction prevention, driving behavior estimation, in-vehicle services customization, etc. However, most of the existing work on in-vehicle positioning relies on special infrastructures, such as the stereo, cigarette lighter adapter or OBD (on-board diagnostic) adapter. In this work, we propose iLoc, an infrastructure-free, in-vehicle, cooperative positioning system via smartphones. iLoc does not require any extra devices and uses only embedded sensors in smartphones to determine the phones' seat-level locations in a car. In iLoc, in-vehicle smartphones automatically collect data during certain kinds of events and cooperatively determine the relative left/right and front/back locations. In addition, iLoc is tolerant to noisy data and possible sensor errors. We evaluate the performance of iLoc using experiments conducted in real driving scenarios. Results show that the positioning accuracy can reach 90% in the majority of cases and around 70% even in the worst-cases.