gebhart/patrepeval huggingface dataset:
Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen. (1989)

We have previously demonstrated that H-2Kd-restricted CTL specific for HLA-CW3 or HLA-A24 can recognize synthetic peptides corresponding to residues 170-182 of the HLA molecules. Synthetic oligonucleotides encoding region 170-182 of CW3 or A24 were inserted into the influenza nucleoprotein (NP) gene. We demonstrate herein that P815 (H-2d) cells transfected with the NP-oligo recombinant genes are specifically lysed by HLA-specific Kd-restricted CTL clones. Our results imply that there must be a high degree of flexibility for the expression of T cell epitopes in different molecular contexts.
Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens. (1999)

Dietary taurine supplementation ameliorates MDA levels, GSSG/GSH, and NAD+/NADH and fails to prevent the osmotically mediated depletion of GSH and taurine and the decrease in glucose utilization and ATP levels in diabetic precataractous lens. Dietary taurine supplementation cannot be regarded as an alternative to aldose reductase inhibition in eliminating antioxidant and metabolic deficits contributing to diabetes-associated cataractogenesis.
Rendering complex scenes for psychophysics using RADIANCE: How accurate can you get? (2006)

Rendering packages are used by visual psychophysicists to produce complex stimuli for their experiments, tacitly assuming that the simulation results accurately reflect the light-surface interactions of a real scene. RADIANCE is a physically based, freely available, and commonly used rendering software. We validated the calculation accuracy of this package by comparing simulation results with measurements from real scenes. RADIANCE recovers color gradients well but the results are shifted in color space. Currently, there is no better simulation alternative for achieving physical accuracy than by combining a spectral rendering method with RADIANCE.
PRIMARY LESION OF A NON-HODGKINʼS LYMPHOMA OCCURRING IN A SKIN TATTOO (1978)

A case of histiocytic lymphoma in a tattoo is presented. The incidence, clinical problems, diagnostic difficulties, treatment, and possible etiology are discussed.
Robust Tracking of Athletes Using Multiple Features of Multiple Views (2004)

This paper presents a robust and reconfigurable object tracker that integrates multiple visual features from\nmultiple views. The tandem modular architecture stepwise refines the estimate of trajectories of the objects in\nthe world coordinates using many plug-ins that observe various features such as texture, color, region and\nmotion in 2D images acquired by the cameras. One of the most important features of our proposed method is\nthat each plug-in innovates the trajectories not only by back-projecting 2D observations of the features, but also\nby weighting them adaptively to their self-evaluated reliability. In the paper, the architecture of the system and\nthat of the plug-ins are formulated. The behavior and robustness against occlusion are also shown through\nexperiments with football-game sequences.
Thermodynamic optimization of downhole heat exchangers for geothermal power generation (2016)

Jeotermal rezervuarlar çeşitli termodinamik ve fiziksel özelliklere sahiptirler. Jeotermal akışkanın üretildiği rezervuarlardan alınabilen/aktarılabilen ısı miktarı ve bu ısıdan üretilen elektrik enerjisi miktarı rezervuar özelliklerine bağlıdır. Kuyu içi ısı değiştirgeçleri (KİID), jeotermal akışkandan ısı alımı/aktarımı işlemini kuyu içinde yapar. Kuyu içine indirilen farklı konfigürasyonlardaki borulardan oluşan KİIDne çalışma akışkanı gönderilir, bu akışkan jeotermal akışkan tarafından ısıtılır ve yüzeye geri dönerek ısıtma yada elektrik üretimi uygulamalarında kullanılabilir. Mevcut uygulamalar ısıtma uygulamaları olup herhangi bir elektrik üretimi uygulaması mevcut değildir. KİID uygulamalarında, kuyu içinde akış olmadığı için taşınım ile ısı transferi katsayısı düşüktür, bu nedenle çalışma akışkanına aktarılan ısı miktarı da kuyu içi pompa uygulamaları ile karşılaştırıldığında düşüktür. Dolayısı ile KİIDleri yüksek sıcaklıklı fakat düşük debili kuyulardan ısı alımı/aktarımı için iyi bir alternatiftir. Dünya’da mevcut bu özellikteki kuyular dikkate alındığında jeotermal santrallerin KİIDleri ile birlikte kullanımı elektrik üretimi için iyi bir potansiyeldir. Tezin amacı, KİIDnin elektrik üretiminde kullanımı için termodinamik ve ekonomik bir model geliştirmektir. Termodinamik model EES yazılımında geliştirilmiş, geliştirilen termodinamik model üzerinde; boru yalıtımı, jeotermal kuyu özellikleri, KİID geometrisi, debi ve çeşitli çalışma akışkanlarının KİID performansına etkilerini belirlemek için 300’den fazla simülasyon gerçekleştirilmiştir. Termodinamik analiz sonuçları; net şimdiki değer, basit geri dönüş süresi ve elektrik üretim maliyeti gibi ekonomik parametreler için de analiz edilmiştir. Çalışmanın sonuçlarından biri KİID geri dönüş borusu üzerinde yalıtımın; ısı kaybı, dolayısı ile de çalışma akışkanı sıcaklığının düşümü açısında hayati olduğudur. Jeotermal akışkandan maximum ısı alımı için KİID tasarımında en uzun derinlik, en geniş iç boru ve en yüksek debi seçilmelidir. Örnek kuyu koşullarında simülasyonlar sonucu elde edilen en iyi durumda net iş üretimi 3152 kW, yıllık net geliri ve geri ödeme süresi sırasıyla 1.75 milyon dolar ve 2.24 yıldır. Ekonomik analiz sonucu, net bugünkü değer pozitif olduğundan, jeotermal elektrik üretimi için KİID yatırımı kabul edilebilir anlamına gelmektedir.
Anteromedial tibial tubercle transfer without bone graft (1990)

We followed 30 patients for more than 2 years after anteromedial tibial tubercle transfer for persistent patellofemoral pain associated with patellar articular degeneration. Twelve of these patients were followed more than 5 years. We report 93% good and excellent results subjectively and 89% good and excellent results objectively. The quality of improvement was sustained in all 12 of the patients who were evaluated again after more than 5 years from surgery. When examined separately, 75% of those patients with advanced patellar arthrosis achieved a good result; none of these patients achieved an excellent result. Postoperative continuous passive motion has markedly reduced the incidence of stiffness. Serious complications such as compartment syndrome, infection, and skin slough were avoided completely in 51 consecutive cases. Patellofemoral contact pressure studies in five cadaver knees have shown that anteromedial tibial tubercle transfer can provide substantial reduction of patellofemoral contact stress while helping to balance medial and lateral facet pressures. This surgical procedure is mechanically and clinically successful for alleviating intractable pain related to patellar malalignment and articular degeneration. This procedure enables the majority of appropriately selected patients with malalignment and patellar articular degeneration to resume increased levels of activity with substantially diminished pain.
Full‐scale in‐situ biobarrier demonstration for containment and treatment of MTBE (2001)

Abstract The Naval Facilities Engineering Service Center (NFESC), Arizona State University, and Equilon Enterprises LLC are partners in an innovative Environmental Security Technology Certification Program cleanup technology demonstration designed to contain dissolved MTBE groundwater plumes. This full‐scale demonstration is being performed to test the use of an oxygenated biobarrier at Naval Base Ventura County, in Port Hueneme, California. Surprisingly, few cost‐effective in‐situ remedies are known for the cleanup of MTBE‐impacted aquifers, and remediation by engineered in‐situ biodegradation was thought to be an unlikely candidate just a few years ago. This project demonstrates that MTBE‐impacted groundwater can be remediated in‐situ through engineered aerobic biodegradation under natural‐flow conditions. With respect to economics, the installation and operation costs associated with this innovative biobarrier system are at least 50 percent lower than those of a conventional pump and treat system. Furthermore, although it has been suggested that aerobic MTBE biodegradation will not occur in mixed MTBE‐BTEX dissolved plumes, this project demonstrates otherwise. The biobarrier system discussed in this article is the largest of its kind ever implemented, spanning a dissolved MTBE plume that is over 500 feet wide. This biobarrier system has achieved an in‐situ treatment efficiency of greater than 99.9 percent for dissolved MTBE and BTEX concentrations. Perhaps of greater importance is the fact that extensive performance data has been collected, which is being used to generate best‐practice design and cost information for this biobarrier technology. © 2001 John Wiley & Sons, Inc.
gp100209–2M Peptide Immunization of Human Lymphocyte Antigen-A2+ Stage I-III Melanoma Patients Induces Significant Increase in Antigen-Specific Effector and Long-Term Memory CD8+ T Cells (2004)

Thirty-five HLA-A2(+) patients with completely resected stage I-III melanoma were vaccinated multiple times over 6 months with a modified melanoma peptide, gp100(209-2M), emulsified in Montanide adjuvant. Direct ex vivo gp100(209-2M) tetramer analysis of pre- and postvaccine peripheral blood mononuclear cells (PBMCs) demonstrated significant increases in the frequency of tetramer(+) CD8(+) T cells after immunization for 33 of 35 evaluable patients (median, 0.36%; range, 0.05-8.9%). Ex vivo IFN-gamma cytokine flow cytometry analysis of postvaccine PBMCs after brief gp100(209-2M) in vitro activation showed that for all of the patients studied tetramer(+) CD8(+) T cells produced IFN-gamma; however, some patients had significant numbers of tetramer(+) IFN-gamma(-) CD8(+)T cells suggesting functional anergy. Additionally, 8 day gp100(209-2M) in vitro stimulation (IVS) of pre- and postvaccine PBMCs resulted in significant expansion of tetramer(+) CD8(+) T cells from postvaccine cells for 34 patients, and these IVS tetramer(+) CD8(+) T cells were functionally responsive by IFN-gamma cytokine flow cytometry analysis after restimulation with either native or modified gp100 peptide. However, correlated functional and phenotype analysis of IVS-expanded postvaccine CD8(+) T cells demonstrated the proliferation of functionally anergic gp100(209-2M)- tetramer(+) CD8(+) T cells in several patients and also indicated interpatient variability of gp100(209-2M) stimulated T-cell proliferation. Flow cytometry analysis of cryopreserved postvaccine PBMCs from representative patients showed that the majority of tetramer(+) CD8+ T cells (78.1 +/- 4.2%) had either an "effector" (CD45 RA(+)/CCR7(-)) or an "effector-memory" phenotype (CD45RA(-)/CCR7(-)). Notably, analysis of PBMCs collected 12-24 months after vaccine therapy demonstrated the durable presence of gp100(209-2M)-specific memory CD8(+) T cells with high proliferation potential. Overall, this report demonstrates that after vaccination with a MHC class I-restricted melanoma peptide, resected nonmetastatic melanoma patients can mount a significant antigen-specific CD8(+) T-cell immune response with a functionally intact memory component. The data further support the combined use of tetramer binding and functional assays in correlated ex vivo and IVS settings as a standard for immunomonitoring of cancer vaccine patients.
A floating point unit for the 68040 (2002)

The Motorola 68040 floating point unit (FPU) combines three independent state machines, two data paths, and over 100000 transistors to achieve 8-Mflops peak performance and over 3-Mflops Linpack double-precision performance at the introductory speed of 25 MHz. It is optimized for minimum latency and maximum pipelined performance on frequently used double-precision floating point instructions. The FPU is architecturally divided into three piped stages, the conversion unit (CU), the execution unit (XU), and the normalization unit (NU). The control logic is tested using scan to achieve very high ATPG fault coverage while the data paths are tested using functional patterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modeling the Responses of Thickness-Shear Mode Resonators under Various Loading Conditions (1999)

We develop a general model that describes the electrical responses of thickness-shear mode resonators subject to a variety of surface conditions. The model incorporates a physically diverse set of single-component loadings, including rigid solids, viscoelastic media, and fluids (Newtonian or Maxwellian). The model allows any number of these components to be combined in any configuration. Such multiple loadings are representative of a variety of physical situations encountered in electrochemical and other liquid-phase applications, as well as gas-phase applications. In the general case, the response of the composite load is not a linear combination of the individual component responses. We discuss application of the model in a qualitative diagnostic fashion to gain insight into the nature of the interfacial structure, and in a quantitative fashion to extract appropriate physical parameters such as liquid viscosity and density and polymer shear moduli.
Multiscale optimization in neural nets (1991)

One way to speed up convergence in a large optimization problem is to introduce a smaller, approximate version of the problem at a coarser scale and to alternate between relaxation steps for the fine-scale and coarse-scale problems. Such an optimization method for neural networks governed by quite general objective functions is presented. At the coarse scale, there is a smaller approximating neural net which, like the original net, is nonlinear and has a nonquadratic objective function. The transitions and information flow from fine to coarse scale and back do not disrupt the optimization, and the user need only specify a partition of the original fine-scale variables. Thus, the method can be applied easily to many problems and networks. There is generally about a fivefold improvement in estimated cost under the multiscale method. In the networks to which it was applied, a nontrivial speedup by a constant factor of between two and five was observed, independent of problem size. Further improvements in computational cost are very likely to be available, especially for problem-specific multiscale neural net methods.
An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin (2013)

A modified invertebrate glutamate-gated Cl(-) channel (GluCl αβ) was previously employed to allow pharmacologically induced silencing of electrical activity in CNS neurons upon exposure to the anthelmintic drug ivermectin (IVM). Usefulness of the previous receptor was limited by 1) the high concentration of IVM necessary to elicit a consistent silencing phenotype, raising concern about potential side effects, and 2) the variable extent of neuronal spike suppression, due to variations in the co-expression levels of the fluorescent protein-tagged α and β subunits. To address these issues, mutant receptors generated via rational protein engineering strategies were examined for improvement. Introduction of a gain-of-function mutation (L9'F) in the second transmembrane domain of the α subunit appears to facilitate β subunit incorporation and substantially increase heteromeric GluCl αβ sensitivity to IVM. Removal of an arginine-based endoplasmic reticulum retention motif (RSR mutated to AAA) from the intracellular loop of the β subunit further promotes heteromeric expression at the plasma membrane possibly by preventing endoplasmic reticulum-associated degradation of the β subunit rather than simply reducing endoplasmic reticulum retention. A monomeric XFP (mXFP) mutation that prevents fluorescent protein dimerization complements the mutant channel effects. Expression of the newly engineered GluCl opt α-mXFP L9'F + opt β-mXFP Y182F RSR_AAA receptor in dissociated neuronal cultures markedly increases conductance and reduces variability in spike suppression at 1 nm IVM. This receptor, named "GluClv2.0," is an improved tool for IVM-induced silencing.
Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With Advanced Solid Tumors (2008)

Everolimus was satisfactorily tolerated at dosages up to 70 mg/wk and 10 mg/d with predictable PK. Antitumor activity and PD in tumors require further clinical investigation. Doses of 20 mg/wk and 5 mg/d are recommended as appropriate starting doses for these studies.
VUML: a viewpoint oriented UML extension (2004)

One of the main challenges of our modern societies is the development of information systems accessible to every citizen with respect to his culture, rights, education etc. A number of such information systems (servers) are now provided on the Web in e-learning, tourism, environment, health, transport, etc. But the development and the maintenance of those systems are not guided by users' profile (viewpoints) and thus such systems are very difficult to adapt, reuse and maintain when a viewpoint must be added/removed/updated. To meet these requirements, we propose an extension of UML called VUML (View based Unified Modeling Language). VUML provides the concept of multiviews component whose goal is to store and deliver information according to users' viewpoints. A multiviews component consists of a default view and a set of specific views related to the base through an extension relation. This approach allows for dynamic change of viewpoints and offers mechanisms to describe views dependencies. To favor reuse and transition to coding, we propose an implementation generic pattern targeting object-oriented languages.
GABAB Receptors Do Not Mediate the Inhibitory Actions of Gabapentin on the Spinal Reflex in Rats (2004)

The clinical effectiveness of gabapentin for the treatment of epilepsy, spasticity, and neuropathic pain has been established. The mechanisms responsible for those actions, however, are still not clearly understood. We have recently demonstrated that gabapentin reduces the spinal reflex in rats via mechanisms that do not involve gamma-aminobutyric acid (GABA)A receptors. In the study, we attempted to explore the involvement of GABAB receptors in gabapentin-induced inhibition of the spinal reflexes in spinalized rats. Stimulation of the dorsal root at L5 elicited the segmental mono-(MSR) and polysynaptic reflex (PSR) in the ipsilateral ventral root. The microinjection of gabapentin (1.5 and 5 nmol) into the ventral horn reduced both MSR and PSR, whereas the injection into the dorsal horn only inhibited the PSR, indicating that systemic gabapentin inhibits the MSR at the ventral horn and it inhibits the PSR at both the ventral and dorsal horns. The GABAB-receptor antagonist CGP35348 (0.5 nmol) injected into the ventral horn antagonized the inhibition of the spinal reflexes by the GABAB-receptor agonist baclofen (i.v.) but not by gabapentin (i.v.). Thus, GABAB receptors do not appear to contribute to the gabapentin-induced inhibition of the spinal reflex.
USE OF ERRORS OF PREDICTION IN IMPROVING FORECAST ACCURACY: AN APPLICATION TO WOOL IN AUSTRALIA (1982)

Over the past 20 years, the RAE has produced commodity forecasts in BAE Trends in Australian Agricultural Commodities, Farm Costs and Farm Incomes and other commodity outlook publications. There have been several studies on the accuracy of the forecasts, either comparing RAE forecasts with naive forecasts or making simple calculations of biases and standard deviations. Such approaches are not sufficiently informative in that they do not give any indication of what has caused the inaccuracies, nor of the timing of significant changes in prediction accuracy. In this analysis, an attempt is made to improve upon this situation using some tools of time series analysis.
Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Islets (2021)

Abstract Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in newborns and infants and arises from dysregulated insulin secretion. Rapid recognition and treatment are vital to prevent seizures, permanent developmental delays, coma, or even death. Very few medical options exist to treat congenital HI patients: the KATP channel activator diazoxide, the injectable somatostatin receptor peptide agonists octreotide and lanreotide, or chronic glucose infusions. However, side effects and/or limited efficacy render these therapies inadequate for many patients. Somatostatin is a 14-amino acid peptide hormone with a broad spectrum of biological actions, which are regulated through five somatostatin receptor subtypes (SST1-SST5). Somatostatin’s common physiological role is to down-regulate secretion of other hormones in various tissues. Its role in the maintenance of euglycemia is to regulate insulin and glucagon secretion from pancreatic β- and α-cells, respectively. Somatostatin regulates insulin secretion by decreasing the intracellular levels of cAMP, inhibition of voltage-gated calcium channels (VGCC), activation of the G protein-activated inward rectifier K+ channel (GIRK), and direct inhibition of insulin exocytosis. Several studies have evaluated the effect of somatostatin, somatostatin peptide analogs, and a limited number of nonpeptide somatostatin receptor agonists on insulin secretion in static assays using isolated human islets. However, the lack of highly selective agonists has made the interpretation of the contribution of SST receptor sub-types difficult to discern. Our programs for the treatment of hyperinsulinism, acromegaly, and other indications have led to the development of selective nonpeptide SST2, SST3, SST4, and SST5 agonists, possessing EC50s &lt; 1 nM in cell-based assays of receptor activation and selectivity &gt; 130 times over the other members of the family. The ability of these selective nonpeptide agonists to regulate glucose- and tolbutamide-stimulated dynamic insulin secretion from human islets was evaluated using a perifusion system (Biorep, FL). We found that selective SST2 and SST5 agonists potently suppressed dynamic insulin secretion in contrast to SST3 or SST4 selective agonists. Importantly, SST5 agonists were shown to have a greater effect than selective SST2 agonists or diazoxide, demonstrating their potential utility in human conditions such as congenital HI. In addition, SST5 activation is also known to have a smaller effect on glucagon secretion and is also less prone to agonist-driven desensitization than SST2 activation. Taken together, these studies support our program to identify, characterize, and develop potent, nonpeptide, orally-bioavailable, selective SST5 agonists with appropriate pharmaceutical and safety characteristics for the treatment of congenital HI.
Perceptual Soundfield Reconstruction in Three Dimensions via Sound Field Extrapolation (2019)

Perceptual sound field reconstruction (PSR) is a spatial audio recording and reproduction method based on the application of stereophonic panning laws in microphone array design. PSR allows rendering a perceptually veridical and stable auditory perspective in the horizontal plane of the listener, and involves recording using near-coincident microphone arrays. This paper extends the PSR concept to three dimensions using sound field extrapolation carried out in the spherical-harmonic domain. Sound field rendering is performed using a two-level loudspeaker rig. An active-intensity-based analysis of the rendered sound field shows that the proposed approach can render direction of monochromatic plane waves accurately.