gebhart/patrepeval huggingface dataset:
High frequency modeling of vehicle noise performance of aluminum body structure. (1996)

This presentation is dedicated to Curt Holmer’s contribution to acoustics at Ford Motor Co. The presentation material is based on the work he was involved with during the last part of his life. The results of the 1992 Taurus SEA model are used to assess the effect of an aluminum body structure. The noise performance comparison includes airborne and structure-borne paths. The effect of structural damping is also simulated.
Galectin‐4, a novel neuronal regulator of myelination (2012)

Myelination of axons by oligodendrocytes (OLGs) is essential for proper saltatory nerve conduction, i.e., rapid transmission of nerve impulses. Among others, extracellular matrix (ECM) molecules, neuronal signaling, and axonal adhesion regulate the biogenesis and maintenance of myelin membranes, driven by polarized transport of myelin-specific proteins and lipids. Galectin-4, a tandem-repeat-type lectin with affinity to sulfatide and nonsialylated termini of N-glycans, has the ability to regulate adhesion of cells to ECM components and is also involved in polarized membrane trafficking. We, therefore, anticipated that galectin-4 might play a role in myelination. Here, we show that in developing postnatal rat brains galectin-4 expression is downregulated just before the onset of myelination. Intriguingly, when immature OLGs were treated with galectin-4, OLG maturation was retarded, while a subset of the immature OLGs reverted to a morphologically less complex progenitor stage, displaying concomitantly an increase in proliferation. Similarly, myelination was inhibited when galectin-4 or anti-galectin-4 antibodies were added to co-cultures of dorsal root ganglion neurons and OLGs. Neurons and OLGs were identified as a possible source of galectin-4, both in vitro and in vivo. In culture, neurons but not OLGs released galectin-4. Interestingly, in co-cultures, a reduced release of endogenous galectin-4 correlated with the onset of myelination. Moreover, galectin-4-reactive sites are transiently expressed on processes of premyelinating primary OLGs, but not on neurons. Taken together, these results identify neuronal galectin-4 as a candidate for a soluble regulator of OLG differentiation and, hence, myelination. © 2012 Wiley Periodicals, Inc.
Real-time Pedestrian Detection Using LIDAR and Convolutional Neural Networks (2006)

This paper presents a pedestrian detection system based on sensor fusion of LIDAR and convolutional neural network based image classifier. This method achieves over 10 frames/second processing speed by utilizing the LIDAR. The focus of this paper is the evaluation of the effect of fusing the LIDAR compared to the image-only system. The evaluation results indicate that fusing the LIDAR can reduce the number of false positives by a factor of 2 and reduce the processing time by a factor of 4. The single frame detection accuracy of the system is above 90% when there is 1 false positive/second. For the covering abstract see E134653.
Effects of a Dan Shen component, magnesium lithospermate B, in nephrectomized rats. (1995)

Magnesium lithospermate B, a compound newly isolated from Dan Shen, was given orally to rats for 70 days after excision of five-sixths of their kidney volume. As a result, mesangial proliferation, tubulo-interstitial lesions and glomerular sclerotic lesions, which were conspicuous in rats that were not given magnesium lithospermate B after nephrectomy, were inhibited. Furthermore, a decrease in blood urea nitrogen, improvement of hypoproteinemia, hypoalbuminemia and hypercholesteremia, and inhibition of urinary protein excretion were observed. The levels of creatinine, methylguanidine and guanidino-succinic acid, which accumulate in the blood with the progress of renal failure, were decreased significantly in rats given magnesium lithospermate B. These results indicate that magnesium lithospermate B, a component of an Oriental medicine has potential as a new therapeutic agent for inhibiting the progression of renal dysfunction.
The adrenergic, cholinergic and NANC nerve‐mediated contractions of the female rabbit bladder neck and proximal, medial and distal urethra (1998)

1. The nerve-mediated contraction of the female rabbit bladder neck and different portions of the urethra (proximal, medial and distal) was studied in vitro by electrical stimulation (50 V, 30 Hz, 0.05 ms width, trains of 5 s every 5 min) by use of a superfusion system. 2. The amplitude (Emax) and the duration (Dmax) of the stimulated contraction were studied in the four tissues. The Emax value was significantly higher in distal urethra (2.07+/-0.15 g) compared to the bladder neck (1.08+/-0.10 g), proximal urethra (0.73+/-0.07 g) and medial urethra (0.87+/-0.07 g). In contrast, the Dmax value appeared slightly but significantly lower (P<0.05) in distal urethra (68.5+/-2.3 s) than in bladder neck (76.7+/-6.0 s), proximal urethra (84.5+/-5.0 s) and medial urethra (81.3+/-3.5 s). 3. Cocaine (1 microM) significantly increased the basal Emax values in medial and distal urethra and the basal Dmax values in the four tissues. 4. Prazosin (1 microM) significantly reduced E max value in proximal, medial and distal urethra and Dmax value in bladder neck and proximal urethra. Atropine (1 microM) also significantly reduced Emax values in bladder neck and proximal urethra and reduced Dmax value in bladder neck, but not in other tissues. Yohimbine (0.1 microM) was devoid of effect in the four tissues. 5. The association of prazosin (1 microM) and atropine (1 microM) did not modify the Emax and the Dmax values of the electrically-induced contractions, except in proximal urethra and in bladder neck where an additive inhibitory effect (on Emax only) was observed compared to prazosin and atropine alone. 6. The residual contractile response after combined treatment with prazosin and atropine was significantly diminished by tetrodotoxin (TTX; 1 microM) but not completely abolished. These NANC contractions were insensitive to P2X-purinoceptor desensitization by continuous tissue perfusion with alpha,beta-methylene ATP (30 microM). 7. These results demonstrate that bladder neck and proximal urethra are mainly innervated by the parasympathetic nervous system, whereas medial and distal urethras are to a greater extent under the control of the sympathetic innervation. The residual responses, insensitive to prazosin and atropine, may indicate a NANC innervation in the four tissues. However, the nature of the NANC neurotransmitter remains to be identified.
Feedback-error-learning neural network for the automatic maneuvering system of a ship (2002)

Recently optimal control theory has been applied to the control of the maneuvering motion of a ship. But there are some problems for practical use. So the author tries here to apply the feedback-error-learning neural network technique proposed by Kawato et al. (1987) to the automatic maneuvering system of a ship. The characteristics of the control system studied here are that the system has the inverse dynamics model of the controlled object and it is composed of the feedforward control loop besides the feedback control loop. The inverse dynamics model is considered as a neural model, and it is refined with learning. Here the control system for the follow-up control to the desired value and for the compensation of the influence from the disturbance is studied by computer simulation. It is recognized that the system has a self-tuning ability and a good controllability and that by adding the proportional term to the learning equation, the learning speed is hastened remarkably. This control system is expected to be put to practical use.
Ferroelectric thin film research in france (1992)

Abstract After a review of the research made on thin film deposition in France, this work presents the comparison between two chemical deposition methods for PZT films: sol-gel method based on low molecular weight precursors and solvent, and MOD (Metallo-Organic Deposition) process based on a hydrophobic solvent. The influence of the viscosity of the solvent and of the solubility of water is shown with regard to stability and drying properties. The final electrical properties of the ferroelectric films are also compared such as the hysteresis loop which characterizes the most important properties for memory application: coercive voltage and rectangularity.
Adipose‐derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation (2012)

Obesity is closely associated with the progression of vascular disorders, including atherosclerosis and postangioplasty restenosis. C1q/TNF-related protein (CTRP) 9 is an adipocytokine that is down-regulated in obese mice. Here we investigated whether CTRP9 modulates neointimal hyperplasia and vascular smooth muscle cell (VSMC) proliferation in vivo and in vitro. Left femoral arteries of wild-type (WT) mice were injured by a steel wire. An adenoviral vector expressing CTRP9 (Ad-CTRP9) or β-galactosidase as a control was intravenously injected into WT mice 3 d before vascular injury. Delivery of Ad-CTRP9 significantly attenuated the neointimal thickening and the number of bromodeoxyuridine-positive proliferating cells in the injured arteries compared with that of control. Treatment of VSMCs with CTRP9 protein attenuated the proliferative and chemotactic activities induced by growth factors including platelet-derived growth factor (PDGF)-BB, and suppressed PDGF-BB-stimulated phosphorylation of ERK. CTRP9 treatment dose-dependently increased cAMP levels in VSMCs. Blockade of cAMP-PKA pathway reversed the inhibitory effect of CTRP9 on DNA synthesis and ERK phosphorylation in response to PDGF-BB. The present data indicate that CTRP9 functions to attenuate neointimal formation following vascular injury through its ability to inhibit VSMC growth via cAMP-dependent mechanism, suggesting that the therapeutic approaches to enhance CTRP9 production could be valuable for prevention of vascular restenosis after angioplasty.
Preliminary studies on a magneto-optical procedure for aligning RHIC magnets (2002)

Colloid dispersions of magnetite were used at SLAC and KEK to locate multipole magnet centers. We study here possible adaption of this method, to align RHIC magnets. A procedure for locating magnetic centers with respect to external fiducial markers, using electronic coordinate determination and digital TV image processing is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug (2011)

Drug/polymer nanoparticles are well suited for providing rapid oral absorption and increased bioavailability of BCS Class II drugs.
Petroleum Distillation (1951)

Today's petroleum distillation plants are compared with the units in existence in 1925, and a review is presented of the advances during the past 25 years in construction practices and materials, instrumentation, and engineering design, which have made possible the current technology. The theory and application of special processes, such as azeotropic and extractive distillation and Hypersorption, are discussed. The development of molecular distillation and rotary columns is described to indicate possible trends to be expected in the future.
Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells (2015)

The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase involved in cell cycle. During the metaphase-anaphase transition the APC/C is activated by Cdc20. The aim of this study is to elucidate the importance and therapeutic potential of APC/C and its co-activator Cdc20 in multiple myeloma (MM). Gene expression analysis revealed that Cdc20 was expressed at higher levels in gene expression-based high-risk MM patients. Moreover, high Cdc20 expression correlated with poor prognosis. Treatment of human myeloma cell lines with proTAME, an APC/C inhibitor, resulted in an accumulation of APC/CCdc20 substrate cyclin B1 and an accumulation of cells in metaphase. Moreover we observed a significant dose-dependent decrease in viability and increase in apoptosis in MM cells upon proTAME treatment. The induction of apoptosis was accompanied with caspase 3, 8, 9 and PARP cleavage. A similar metaphase arrest and induction of apoptosis were obtained with specific knockdown of Cdc20. In addition, we demonstrated the accumulation of Bim was partially responsible for the observed cell death. Combining proTAME with another APC/C inhibitor apcin or the alkylating agent melphalan resulted in enhanced anti-MM activity. This study suggests that the APC/C and its co-activator Cdc20 could be a new and promising target especially in high-risk MM patients.
Generalized Theory of Multitone Amplitude and Frequency Modulation (1947)

The frequency spectrum produced by single-tone, two-tone, and multitone modulating signals in the case of amplitude modulation, frequency modulation, and combined amplitude and frequency modulation are studied in turn. Amplitude, symmetry, and energy of sidebands for the different cases are considered. Extensive computations are made of frequency spectrums, and these are compared with actual frequency spectrums observed by means of a spectrum analyzer. The agreement between computed and measured frequency spectrums is very close.
Some New β-Diketones Containing the Trifluoromethyl Group<sup>1a</sup> (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome New β-Diketones Containing the Trifluoromethyl Group1aJ. C. Reid and M. CalvinCite this: J. Am. Chem. Soc. 1950, 72, 7, 2948–2952Publication Date (Print):July 1, 1950Publication History Published online1 May 2002Published inissue 1 July 1950https://pubs.acs.org/doi/10.1021/ja01163a038https://doi.org/10.1021/ja01163a038research-articleACS PublicationsRequest reuse permissionsArticle Views964Altmetric-Citations197LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Zero copy I: user-mode perspective (2003)

Apache and Samba use the sendfile system call to speed up file serving. Here's how you can use it too.
TaN thin films for Superconducting Nanowire Single-Photon Detectors (2010)

Development of superconducting nanowire single-photon detectors (SNSPD) with a higher intrinsic detection efficiency, stronger absorption in a wider spectral range stimulates a study of thin films of different superconducting materials. The tantalum\nnitride TaN thin films are typically used as an insulator in\nmulti-layer system for SIS device fabrication [1] or as cover layer to improve the hardness and chemical stability of any surfaces. At the same time there are only few and sometimes contradictory publications about superconductivity in thin films of TaN [1, 2]. We present results on fabrication and characterization\nof TaN thin films with a focus on their application in\ndevelopment of SNSPD devices.
Innovations for Sustainable Infrastructure – Experience from Azerbaijan Rural Investment Project (AZRIP) (2010)

Over the past decade plus, Community Driven Development (CDD) has proven to be an effective strategy for promoting the development of small-scale infrastructure. Indeed, by involving community members in decision-making processes and project implementation, the CDD approach increases community ownership of investments projects and enhances their sustainability. However, despite its successes in the realm of small scale infrastructure, CDD's track record in promoting sustainability for more complex infrastructure projects (such as roads and water supply systems) is mixed at best and the connection between community ownership and sustainable infrastructure is not well established for larger scale projects. In order to ensure that the 'triple bottom line' of sustainable infrastructure is met in the context of CDD operations, infrastructure investments need to be selected and implemented using an integrated approach that combines sound economics, solid engineering and attention to social dynamics and environmental sustainability. By successfully incorporating a variety of innovations, the Azerbaijan Rural Investment Project (AZRIP) demonstrates how adopting a comprehensive approach, including a focus on life-cycle costs, private sector participation, and participatory processes, is critical for achieving sustainable infrastructure investments. As such, AZRIP serves as a good example of how close engagement with communities and attention to sustainability in project design and implementation can lead to positive development outcomes and the achievement of the 'triple bottom line'.
Milolides G−N, New Briarane Diterpenoids from the Western Pacific Octocoral <i>Briareum stechei</i> (2002)

Twelve new briarane diterpenes, designated milolides (1-12), and one known diterpene, 9-deacetylstylatulide lactone (13), were isolated from the Micronesian octocoral Briareum stechei collected at Yap, Federated States of Micronesia. Their structures were determined from spectral data.
Block copolymer self assembly for design and vapor phase synthesis of one-dimensional nanostructured materials (2014)

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Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6 (2001)

Adenosine is formed in the intestinal lumen during active inflammation from neutrophil-derived 5' AMP. Using intestinal epithelial cell line T84, we studied the effect of adenosine on the secretion of IL-6, a proinflammatory cytokine involved in neutrophil degranulation and lymphocyte differentiation. Stimulation of T84 monolayers with either apical or basolateral adenosine induces A2b receptor-mediated increase in IL-6 secretion, which is polarized to the apical (luminal) compartment. In addition, Salmonella typhimurium, TNF-alpha, and forskolin, known inducers of IL-6 secretion in intestinal epithelial cells, also stimulate IL-6 secretion into the apical compartment. We show that IL6 promoter induction by adenosine occurs through cAMP-mediated activation of nuclear cAMP-responsive element-binding protein (CREB). We also show that IL-6 released in the luminal (apical) compartment achieves a sufficient concentration to activate neutrophils (from which the adenosine signal originates), since such IL-6 is found to induce an intracellular [Ca(++)] flux in neutrophils. We conclude that adenosine released in the intestinal lumen during active inflammation may induce IL-6 secretion, which is mediated by cAMP/CREB activation and occurs in an apically polarized fashion. This would allow sequential activation of neutrophil degranulation in the lumen -- a flow of events that would, in an epithelium-dependent fashion, enhance microbicidal activity of neutrophils as they arrive in the intestinal lumen.
Soy protein isolate in the presence of cornstarch reduces body fat gain in rats (1998)

The objective of the present study was to determine the combined effects of dietary protein and carbohydrate sources on total body energy and protein and fat gains as well as on plasma insulin and glucose and tissue lipoprotein lipase activity in male Sprague-Dawley rats fed semipurified diets for 28 days. The diets varied in both protein and carbohydrate sources, namely, casein-cornstarch, casein-sucrose, soy protein isolate (SPI) - cornstarch, SPI-sucrose, cod protein - cornstarch, and cod protein - sucrose. When SPI was combined with cornstarch, lower total body energy and fat gains were observed compared with the combination of either casein and sucrose, casein and cornstarch, or SPI and sucrose. Plasma glucose and insulin concentrations in addition to total and metabolizable energy intake and body weight gain were lower in rats fed the SPI-cornstarch diet than in those fed the casein-sucrose diet. Feeding the SPI-cornstarch diet compared with feeding either the casein-cornstarch or the SPI-sucrose diet also caused lower plasma glucose concentrations and a concomitant trend ( p = 0.06) to reduced energy intake and body weight gain. Therefore, the reducing effects of the SPI-cornstarch diet compared with the casein-cornstarch, the casein-sucrose, and the SPI-sucrose diets on body energy and fat gains may result from reductions in energy intake and in plasma glucose concentrations.Key words: dietary proteins, soy protein, dietary carbohydrates, body fat, plasma glucose, plasma insulin.
Megagate ASICs for the Thuraya satellite digital signal processor (2003)

Boeing Satellite Systems and IBM have designed and fabricated a, set of ASIC chip types to perform computation-intensive digital signal processing (DSP) functions on board geosynchronous satellites of the Thuraya mobile communications system. Preparation for this application required comprehensive review of the reliability and space-worthiness of the underlying process and packaging technology. First-pass success on all nine million-plus-gate ASIC designs required extensive model-based simulation and verification. These technologies allowed a four-fold increase in the computational power of the DSP unit over previous systems based on radiation-hardened ASICs, while simultaneously decreasing the number of ASICs required by another factor of five. The first Thuraya satellite is on-orhit, and the whole communications system is performing flawlessly.