gebhart/patrepeval huggingface dataset:
Evaluating the quality of approximations to the non-dominated set (1998)

: The growing interest in hard multiple objective combinatorial and non-linear problems resulted in a significant number of heuristic methods aiming at generating sets of feasible solutions as approximations to the set of non-dominated solutions. The issue of evaluating these approximations is addressed. Such evaluations are useful when performing experimental comparisons of different multiple objective heuristic algorithms, when defining stopping rules of multiple objective heuristic algorithms, and when adjusting parameters of heuristic algorithms to a given problem. A family of outperformance relations that can be used to compare approximations under very weak assumptions about a decision-maker&apos;s preferences is introduced. These outperformance relations define incomplete orders in the set of all approximations. It is shown that in order to compare approximations, which are incomparable according to the outperformance relations, much stronger assumptions about the decision-maker&apos;s p...
An adaptive protection framework for mepeg base layer video streaming over internet (2004)

Video streaming over the Internet or wireless environment is an imperative application. However, packetized video frames suffer from random losses when they are streamed over the Internet. Packet losses degrade video quality, even if applications adopt error resilience techniques. To provide more guaranteed video quality, we re-investigate the PET system (Albanese et al., November 1996) and propose an adaptive optimization-based protection assignment framework based on PET for streaming MPEG base layer video under a given bandwidth constraint Our framework incorporates considerations of both the variant bandwidth issue and the packet loss issue on the Internet. The results of our experiments demonstrate our proposed framework achieves the goal of adaptive optimization assignment for MPEG video streaming.
Monocular RGB Hand Pose Inference from Unsupervised Refinable Nets (2018)

3D hand pose inference from monocular RGB data is a challenging problem. CNN-based approaches have shown great promise in tackling this problem. However, such approaches are data-hungry, and obtaining real labeled training hand data is very hard. To overcome this, in this work, we propose a new, large, realistically rendered hand dataset and a neural network trained on it, with the ability to refine itself unsupervised on real unlabeled RGB images, given corresponding depth images. We benchmark and validate our method on existing and captured datasets, demonstrating that we strongly compare to or outperform state-of-the-art methods for various tasks ranging from 3D pose estimation to hand gesture recognition.
Letter (2005)

I read with great pleasure the recent article by Joe Simone regarding ASCO and ethics. I have long wondered why someone has not come out and said some of the things you have brought to the forefront. I'm glad you are able to take this position. It is long overdue. I look forward to your controversial articles again in the future. Jay Locke, MD
Nonlinear Trajectory Control of Autonomous Underwater Vehicles Using the Sliding Methodology (1984)

A new variation on sliding control is shown to be very effective for the control of underwater vehicles. The method deals with nonlinearities directly, is highly robust to imprecise models, and is intuitively appealing. The method is demonstrated using a nonlinear vehicle simulation.
Herpes simplex virus infection can occur without involvement of the fibroblast growth factor receptor (1992)

Basic fibroblast growth factor (bFGF) has been reported to block uptake of herpes simplex virus type 1 (HSV-1) and plaque formation on arterial smooth muscle cells, suggesting a role for the bFGF receptor in HSV entry (R. J. Kaner, A. Baird, A. Mansukhani, C. Basilico, B. D. Summers, R. Z. Florkiewicz, and D. P. Hajjar, Science 248:1410-1413, 1990). We confirmed the effect of bFGF on infection of this cell type with HSV-1 and HSV-2 and found the same result with umbilical vein endothelial cells. However, bFGF does not inhibit plaque formation on any other cell type we tested. Furthermore, there is no correlation between the level of expression of the bFGF receptor and the effect of bFGF. HEp-2 and A431 cells express barely detectable levels of receptor, and yet they are fully permissive for HSV infection in a bFGF-insensitive manner. Thus, interaction of virus with the bFGF receptor is not required for infection of many cell types. In addition, infection of smooth muscle cells is not prevented by incubation of virus with an anti-bFGF antibody, arguing against the hypothesis that virion-associated bFGF acts as a bridge between virus and receptor (A. Baird, R. Z. Florkiewicz, P. A. Maher, R. J. Kaner, and D. P. Hajjar, Nature [London] 348:344-346, 1990).
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors (2022)

It is a challenge to effectively reactivate preexisting tumor-infiltrating lymphocytes (TILs) without causing severe toxicity. Interleukin-12 (IL-12) can potently activate lymphocytes, but its clinical use is limited by its short half-life and dose-related toxicity. In this study, we developed a tumor-conditional IL-12 (pro-IL-12), which masked IL-12 with selective extracellular receptor–binding domains of the IL-12 receptor while preferentially and persistently activating TILs after being unmasked by matrix metalloproteinases expressed by tumors. Systemic delivery of pro-IL-12 demonstrated reduced toxicity but better control of established tumors compared with IL-12-Fc. Mechanistically, antitumor responses induced by pro-IL-12 were dependent on TILs and IFNγ. Furthermore, direct binding of IL-12 to IL-12R on CD8<sup>+</sup>, not CD4<sup>+</sup>, T cells was essential for maximal effectiveness. Pro-IL-12 improved the efficacy of both immune checkpoint blockade and targeted therapy when used in combination. Therefore, our study demonstrated that pro-IL-12 could rejuvenate TILs, which then combined with current treatment modalities while limiting adverse effects for treating established tumors.
Optical-fibre end preparation by spark erosion (1976)

Before splicing two optical-fibre waveguides, endfaces have to be prepared which are plane and perpendicular to the fibre axis A new method for preparing endfaces is proposed which is simple and reliable. The fibre surface is eroded by sparks and the fibre is then broken by hand.
Sub-angstrom modeling of complexes between flexible peptides and globular proteins (2010)

A wide range of regulatory processes in the cell are mediated by flexible peptides that fold upon binding to globular proteins. Computational efforts to model these interactions are hindered by the large number of rotatable bonds in flexible peptides relative to typical ligand molecules, and the fact that different peptides assume different backbone conformations within the same binding site. In this study, we present Rosetta FlexPepDock, a novel tool for refining coarse peptide-protein models that allows significant changes in both peptide backbone and side chains. We obtain high resolution models, often of sub-angstrom backbone quality, over an extensive and general benchmark that is based on a large nonredundant dataset of 89 peptide-protein interactions. Importantly, side chains of known binding motifs are modeled particularly well, typically with atomic accuracy. In addition, our protocol has improved modeling quality for the important application of cross docking to PDZ domains. We anticipate that the ability to create high resolution models for a wide range of peptide-protein complexes will have significant impact on structure-based functional characterization, controlled manipulation of peptide interactions, and on peptide-based drug design.
A Survey of Sensitization in 5xxx Series Aluminum Alloys (2015)

The 5xxx series (Al-Mg-based) aluminum alloys suffer from intergranular corrosion and intergranular stress corrosion cracking when the alloy has become “sensitized.” Sensitization refers to insidious precipitation of β phase (Mg2Al3), which is problematic when present at grain boundaries. The β phase is electrochemically active and may preferentially dissolve. This paper reviews the relevant works that have documented the degree of sensitization for various 5xxx series alloys, providing a holistic overview of the issue, along with attention to the bulk composition, heat treatment, and microstructure.
Direct Glycosylations with 1-Hydroxy Glycosyl Donors using Trifluoromethanesulfonic Anhydride and Diphenyl Sulfoxide (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDirect Glycosylations with 1-Hydroxy Glycosyl Donors using Trifluoromethanesulfonic Anhydride and Diphenyl SulfoxideBrian A. Garcia, Jennifer L. Poole, and David Y. GinView Author Information Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 Cite this: J. Am. Chem. Soc. 1997, 119, 32, 7597–7598Publication Date (Web):August 13, 1997Publication History Received4 April 1997Published online13 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja971067yhttps://doi.org/10.1021/ja971067yrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2919Altmetric-Citations197LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Free radicals,Hydrocarbons,Oxides,Post-translational modification Get e-Alerts
Visualizing Uncertainty in Geo-spatial Data (2001)

This paper focuses on how computer graphics and visualization can help users access and understand the increasing volume of geo-spatial data. In particular, this paper highlights some of the visualization challenges in visualizing uncertainty associated with geo-spatial data. Uncertainty comes in a variety of forms and representations, and require different techniques for presentation together with the underlying data. In general, treating the uncertainty values as additional variables of a multivariate data set is not always the best approach. We present some possible approaches and further challenges using two illustrative application domains
Is Hydroxyapatite a Reliable Fixation Option in Unicompartmental Knee Arthroplasty? –<i>A 5- to 13-Year Experience with the Hydroxyapatite-Coated Unix Prosthesis</i> (2008)

Hydroxyapatite-coated unicompartmental knee arthroplasty (UKA) is a debatable approach to unicompartmental knee arthritis because UKA is often viewed as a short-term solution, at best, for a condition that will eventually require a total knee arthroplasty (TKA). Unicompartmental knee arthroplasty is a more technically demanding procedure than TKA, and appropriate patient selection, careful surgical technique, and correct choice of implant geometry are all critical components to its success. A fundamental issue surrounding UKA is whether hydroxyapatite-coated unicompartmental components can provide a long-term solution to unicondylar arthritis. We address this issue in the current study, which is based on a prospective series of 125 hydroxyapatite-coated Unix knee prostheses implanted consecutively between 1994 and 2002, with a 5-year minimum follow-up and a 13-year maximum follow-up. The results of our study indicate that uncemented hydroxyapatite-coated UKA can be successful in the long term.
Using OWL to Model Role Based Access Control (2008)

Current access control research follows two parallel themes: many efforts focus on developing novel access control models meeting the policy needs of real world application domains while others are exploring new policy languages. This paper is motivated by the desire to develop a synergy between these themes facilitated by OWL. Our vision for the future is a world where advanced access control concepts are embodied in models that are supported by policy languages in a natural intuitive manner, while allowing for details beyond the models to be further specified in the policy language. In this paper we specifically study the relationship between the Web Ontology Language (OWL) and the Role Based Access Control (RBAC) model. Although OWL is a web ontology language and not specifically designed for expressing authorization policies, it has been used successfully for this purpose in previous work. We show two different ways to support the NIST Standard RBAC model in OWL and then discuss how the OWL constructions can be extended to model attribute-based RBAC or more generally attribute-based access control.
The unbearable lightness of prehistory. Archaelogical reflections on material culture and time (2006)

Clinical Trials (WHO) ChiCTR-IOR-15006117 registered on 20 March 2015.
Erbium-doped fiber amplifiers with wavelength-selective optical feedback (1996)

An optically-controlled fiber ring laser behaving as a low-speed all-optical inverter was demonstrated. Applications in fault location for lightwave systems, nonlinear optical circuitry and simple logic functions are described. Two inverters using erbium-doped fiber amplifiers were cross-coupled to form an all-optical guided-wave set/reset hip-hop that had greater than 40-dB extinction ratio and a state transition time of 1.6 ms.
Analysis of symmetric varactor frequency multipliers (1997)

We investigate efficiency limitations of frequency multipliers with the use of a simple model for symmetric varactors. Our calculations show that the conversion efficiency is improved for a C(V) shape with large nonlinearity at zero volt bias. For quintuplers, the optimal embedding impedance at the third harmonic is an inductance in resonance with the varactor diode capacitance. © 1997 John Wiley & Sons, Inc. Microwave Opt Technol Lett 15: 26–29, 1997.
Spectrally resolved fluorescence lifetime imaging microscope using tunable bandpass filters (2012)

A simple structure of spectral fluorescence lifetime imaging microscope (SLIM) is designed with the use of tunable bandpass filter, a kind of Fabry-perot filter that transmission wavelength is varying according to incident angle of light. Feasibility tests of this angle-tuned bandpass filter (ATBF) are performed and it shows high transmission and constant spectral bandwidth (20 nm) with respect to angle of incidence. Furthermore, using two ATBFs in series, spectral bandwidth can be adjustable down to 4 nm. In this paper, dual ATBFs are implemented to the detection part of fluorescence lifetime imaging microscope (FLIM) system so that we obtained spectrally resolved FLIM images. We compare these SLIM images with an original FLIM image and confirm that the former case provides high accuracy to analyze lifetime distribution as well as high contrast of images. The proposed SLIM microscope with good wavelength selectivity has many opportunities to utilize to other applications such as FLIM-Föster resonant energy transfer and autofluorescence imaging.
Sensor deployment by a robot in an unknown orthogonal region: Achieving full coverage (2014)

When deploying a wireless sensor network in an unknown environment, commonly referred to as Region of Interest (ROI), the main goal is for the entire region to be covered by the sensing ranges of the deployed sensors. While this goal of full coverage is easily achieved in presence of human intervention, it becomes problematic if the region is dangerous or inaccessible to human. An approach recently proposed to solve the problem is to use a robot to deploy the sensors; the main advantages respect to the alternative of employing mobile sensors are the reduced costs (due to manufacture and maintenance cost of common static sensors vs. mobile ones) and the reduced complexity of the coordination and control algorithms. Indeed several solution algorithms to achieve deployment of sensors by a robot in an unknown region have been proposed in the literature. Unfortunately, even when restricted to orthogonal regions (e.g., city maps, building plans, etc), all the existing algorithms fail to achieve full coverage of the ROI. Specifically, following the existing protocols, the robot would leave uncovered areas near either the boundaries or critical areas (e.g. areas that are linked to the rest of the region by a narrow corridor). In this paper we present an algorithm that overcomes these problems and guarantees that the deployment of the sensors by the robot achieves full coverage in any simply connected orthogonal ROI, whose topology is unknown to the robot. The proposed algorithm has minimal requirements: it does not need GPS but only local orientation by the robot; the communication range of a deployed sensor is limited to its deployed neighbours, and the robot has a similar range; the total number of sensors used is minimal. Also minimal are the robot's memory requirements, the total amount of robots movements and of communication between robot and sensors.
Evolution of Reconfigurable Submarine Fiberoptic Networks (2019)

Undersea systems evolution toward capacity and connectivity optimization at the overall cable rather than fiber pair will benefit from enhanced reconfigurable spectrum routing options, and from API-based management for new levels of customized network control functionality.
Endogenous digitalis-like factors (1993)

Since the early 1960s increasing evidence has been accumulated by de Wardener [1] supporting the existence of a natriuretic hormone. Dahl et al. [2] proposed that the salt-induced hypertension in the salt-sensitive rat must be caused by a low molecular humoral factor released in response to salt ingestion. The hypertensinogenic substance could be transferred via parabiosis. It was therefore assumed to be stable and of long duration. Much support for this concept came from the work of Haddy and Overbeck [3–5] who found that Na+/K+-ATPase in vascular smooth muscle cells was chronically inhibited in hypertensive animals and in patients with low plasma renin activity. They suggested that the vasoconstriction in these various types of volume- expanded hypertension was caused by a humoral inhibitor of the sodium pump. Later the idea was put forward by Blaustein [6] and MacGregor [7] that such an natriuretic factor may also produce essential hypertension. Since a substance that binds like digitalis to the cardiac glycoside receptor site of the sodium pump could produce such effects, the term of endogenous digitalis-like activity [8–11] or digitalis-like factor (EDLF) [12] came up. This assumption is analogous to that which led to the identification of the opioid peptides (endorphins and enkephalins) as ligands of the opiate receptor [13].
Can the tea tree oil (Australian native plant:<i>Melaleuca alternifolia Cheel</i>) be an alternative treatment for human demodicosis on skin? (2018)

Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Although current treatments other than TTO and T4O are relatively effective in controlling the demodex mite population and the related symptoms, more research on the efficacy and drug delivery technology is needed in order to assess its potential as an alternative treatment with minimal side-effect profile, low toxicity and low risk of demodex resistance.
New Compounds. Thiofuroic Acid (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Compounds. Thiofuroic AcidS. PattonCite this: J. Am. Chem. Soc. 1949, 71, 10, 3571–3572Publication Date (Print):October 1, 1949Publication History Published online28 October 2002Published inissue 1 October 1949https://pubs.acs.org/doi/10.1021/ja01178a604https://doi.org/10.1021/ja01178a604research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Late Blight Resistance Locus <i>Rpi-blb3</i> from <i>Solanum bulbocastanum</i> Belongs to a Major Late Blight <i>R</i> Gene Cluster on Chromosome 4 of Potato (2005)

Late blight, caused by Phytophthora infestans, is one of the most devastating diseases in cultivated potato. Breeding of new potato cultivars with high levels of resistance to P. infestans is considered the most durable strategy for future potato cultivation. In this study, we report the identification of a new late-blight resistance (R) locus from the wild potato species Solanum bulbocastanum. Using several different approaches, a high-resolution genetic map of the new locus was generated, delimiting Rpi-blb3 to a 0.93 cM interval on chromosome 4. One amplification fragment length polymorphism marker was identified that cosegregated in 1,396 progeny plants of an intraspecific mapping population with Rpi-blb3. For comparative genomics purposes, markers linked to Rpi-blb3 were tested in mapping populations used to map the three other late-blight R loci Rpi-abpt, R2, and R2-like also to chromosome 4. Marker order and allelic conservation suggest that Rpi-blb3, Rpi-abpt, R2, and R2-like reside in the same R gene cluster on chromosome 4 and likely belong to the same gene family. Our findings provide novel insights in the evolution of R gene clusters conferring late-blight resistance in Solanum spp.
DIAGNOSIS AND TREATMENT OF STROKES: ANATOMICAL AND PATHOLOGICAL ASPECTS (1963)

SUMMARY This report deals with the major findings in an autopsy series of 351 cases of cerebrovascular accident. In addition, anatomical studies are presented which help to clarify some of the pathological findings. In the cases of cerebral infarction, a high incidence of associated heart disease was found. In the hæmorrhage group, the importance of ruptured saccular aneurysm is emphasized.