gebhart/patrepeval huggingface dataset:
Antigen-Specific Tolerance of Human <i>α</i> <sub>1</sub> -Antitrypsin Induced by Helper-Dependent Adenovirus (2007)

As efficient and less toxic virus-derived gene therapy vectors are developed, a pressing problem is to avoid immune response to the therapeutic gene product. Secreted therapeutic proteins potentially represent a special problem, as they are readily available to professional antigen-presenting cells throughout the body. Some studies suggest that immunity to serum proteins can be avoided in some mouse strains by using tissue-specific promoters. Here we show that expression of human alpha1-antitrypsin (AAT) was nonimmunogenic in the immune-responsive strain C3H/HeJ, when expressed from helper-dependent (HD) vectors using ubiquitous as well as tissue-specific promoters. Coadministration of less immunogenic HD vectors with an immunogenic first-generation vector failed to immunize, suggesting immune suppression rather than immune stealth. Indeed, mice primed with HD vectors were tolerant to immune challenge with hAAT emulsified in complete Freund's adjuvant. Such animals developed high-titer antibodies to coemulsified human serum albumin, showing that tolerance was antigen specific. AAT-specific T cell responses were depressed in tolerized animals, suggesting that tolerance affects both T and B cells. These results are consistent with models of high-dose tolerance of B cells and certain other suppressive mechanisms, and suggest that a high level of expression from HD vectors can be sufficient to induce specific immune tolerance to serum proteins.
IBM DB2 Everyplace: a small footprint relational database system (2002)

Handheld and embedded devices are becoming increasingly popular and their uses are more versatile. Applications on these devices often need storing, retrieving and synchronizing of data. IBM DB2 Everyplace is a high performance small footprint DBMS that is targeted at this market segment. The authors describe the overall architecture, features and several design considerations.
The effect of particle structure on apparent density of electrolytic copper powder (2001)

The quantitative microstructural analysis and the sieve analysis of copper powder as well as the scanning electron microscopy analysis of the copper powders particles were performed. It was found that the structure of the copper powder particles determines the apparent density of copper powder. The powder particles from the same fractions of different powders occupy approximately the same volume, but the structure of metallic copper is very different. This causes the difference in apparent densities of copper powder obtained under different conditions. The more dendritic is the structure of powder particles the smaller is the apparent density of copper powder.
Experimental and theoretical studies of nanoparticles of antiferromagnetic materials (2007)

The magnetic properties of nanoparticles of antiferromagnetic materials are reviewed. The magnetic structure is often similar to the bulk structure, but there are several examples of size-dependent magnetic structures. Owing to the small magnetic moments of antiferromagnetic nanoparticles, the commonly used analysis of magnetization curves above the superparamagnetic blocking temperature may give erroneous results, because the distribution in magnetic moments and the magnetic anisotropy are not taken into account. We discuss how the magnetic dynamics can be studied by use of magnetization measurements, Mössbauer spectroscopy and neutron scattering. Below the blocking temperature, the magnetic dynamics in nanoparticles is dominated by thermal excitations of the uniform mode. In antiferromagnetic nanoparticles, the frequency of this mode is much higher than in ferromagnetic and ferrimagnetic nanoparticles, but it depends crucially on the size of the uncompensated moment. Excitation of the uniform mode results in a so-called thermoinduced moment, because the two sublattices are not strictly antiparallel when this mode is excited. The magnetic dipole interaction between antiferromagnetic nanoparticles is usually negligible, and therefore such particles present a unique possibility to study exchange interactions between magnetic particles. The interactions can have a significant influence on both the magnetic dynamics and the magnetic structure. Nanoparticles can be attached with a common crystallographic orientation such that both the crystallographic and the magnetic order continue across the interfaces.
Nonlinear dynamics of semiconductor lasers with active optical feedback (2004)

An in-depth theoretical as well as experimental analysis of the nonlinear dynamics in semiconductor lasers with active optical feedback is presented. Use of a monolithically integrated multisection device of submillimeter total length provides access to the short-cavity regime. By introducing an amplifier section as a special feature, phase and strength of the feedback can be separately tuned. In this way, the number of modes involved in the laser action can be adjusted. We predict and observe specific dynamical scenarios. Bifurcations mediate various transitions in the device output, from single-mode steadystate to self-pulsation and between different kinds of self-pulsations, reaching eventually chaotic behavior in the multimode limit.
Development of a single vial kit formulation of [99mTc]‐labeled doxorubicin for tumor imaging and treatment response assessment‐preclinical evaluation and preliminary human results (2015)

The present study describes the successful radiolabeling of [99mTcO(-) 4 ] with doxorubicin, and the resultant product was formulated in to a ready-to-label lyophilized single vial kit preparation for convenient use in a routine clinical setting. The radiolabeled preparation of [99mTc]-doxorubicin exhibited a high radiolabeling efficiency of more than 95.0%, serum stability for up to 24 h, and shelf-life of lyophilized cold kits was more than 6 months. Animal imaging data in tumor-bearing mice demonstrated that [99mTc]-doxorubicin accumulated in the tumor site with high target (tumor) to non-target (contra-lateral thigh) ratio (3.2 ± 0.5). The ratio decreased to 1.2 ± 0.6 indicating a good response on follow up imaging performed after 2 weeks of doxorubicin treatment. [99mTc]-doxorubicin scintigraphic data in human volunteers supported the hepato-renal excretion of the radiotracer as reflected by the increased accumulation of the radiotracer as a function of time in intestine, kidneys, and urinary bladder. Further, imaging in patients (very limited number) indicated that the technique may be useful in the detection of active sarcoma and post treatment (surgery/chemotherapy) remission or absence of the disease. The technique, however, needs validation through further preclinical evaluation and imaging in a larger number of patients.
Near-infrared optical parametric amplifier at 1 MHz directly pumped by a femtosecond oscillator (2007)

We demonstrate a high-average-power optical parametric amplifier directly pumped by a cavity-dumped Yb:KYW mode-locked laser oscillator at 1 MHz repetition rate. The two-stage system uses periodically poled lithium niobate crystals both for optical parametric generation and for power amplification. We obtain average powers as high as 190 mW with 220 fs average pulse widths and wavelength tunability in the 1.3-1.6 microm (signal) and 3.1-4.6 microm (idler) range.
Redox polymer films containing enzymes. 2. Glucose oxidase containing enzyme electrodes (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRedox polymer films containing enzymes. 2. Glucose oxidase containing enzyme electrodesBrian A. Gregg and Adam HellerCite this: J. Phys. Chem. 1991, 95, 15, 5976–5980Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/j100168a047https://doi.org/10.1021/j100168a047research-articleACS PublicationsRequest reuse permissionsArticle Views1005Altmetric-Citations174LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cognitive decline is faster in Lewy body variant than in Alzheimer's disease (1998)

This study demonstrates that LBV is characterized by a faster cognitive decline and accelerated mortality compared with AD.
Poly(pyrazol-1-ylmethyl)Benzenes: New Multidentate Ligands (1995)

Twelve new multidentate poly(pyrazol-1-ylmethyl)benzene ligands , (5)-(16), have been synthesized by phase-transfer-catalysed alkylations of pyrazoles with poly( bromomethyl )benzenes, and their 1H and 13C n.m.r. spectra have been fully assigned. X-Ray crystal structure determinations have been carried out on the tetrachloropalladate salt of the diprotonated form of 1,4-bis(3,5-dimethylpyrazol-1-ylmethyl)-2,3,5,6-tetramethylbenzene and on hexakis (pyrazol-1-ylmethyl)benzene.
Reactivity evolution during sulfidation of porous zinc oxide (1993)

The sulfidation of porous zinc oxide in hydrogen sulfide—nitrogen mixtures was studied in a thermogravimetric analysis system. Experiments were carried out with particles in the range 52–350 μm, at temperatures from 300 to 600°C, and with different hydrogen sulfide concentrations. The analysis of the experimental results showed that the sulfidation reaction was of first-order with respect to the H2S concentration, and that the conversion vs time trajectories depended strongly on the particle size. The generalized pore model of Yu and Sotirchos, a detailed model for diffusion, reaction, and structure evolution in chemically reacting porous media, was used to analyze the experimental data, and good agreement between model and experiment was observed. The intraparticle diffusional limitations and their evolution with the progress of the reaction were found to be the factor influencing most the sorptive capacity of the ZnO sorbet for H2S removal.
Searching for biomarkers: humoral response profiling with luciferase immunoprecipitation systems (2011)

B-cell-mediated humoral responses are triggered in many human diseases, including autoimmune diseases, cancer, and neurologic and infectious diseases. However, the full exploitation of the information contained within a patient's antibody repertoire for diagnosis, monitoring and even disease prediction has been limited due to the poor diagnostic performance of many immunoassay formats. We have developed luciferase immunoprecipitation systems (LIPS) that harnesses light-emitting proteins to generate high-definition antibody profiles that are optimal for both diagnostics and biomarker discovery. Here, we describe the results and implications from a range of LIPS-antibody profiling studies performed in our laboratory. These include highly sensitive diagnostics for domestic and global pathogens, insights into infection-related diseases, discovery of new biomarkers for human diseases, subcategorization of symptoms and identification of pathogenic autoantibodies against self-proteins. These investigations highlight the types of humoral response profiles associated with different diseases, provide new information related to disease pathogenesis and offer a framework for incorporating LIPS antibody profiling into global health initiatives and disease monitoring.
Myocardial Infarct–Sparing Effect of Adenosine A<sub>2A</sub>Receptor Activation Is due to Its Action on CD4<sup>+</sup>T Lymphocytes (2006)

These results strongly suggest that the infarct-sparing effect of A2AR activation is primarily due to inhibition of CD4+ T-cell accumulation and activation in the reperfused heart.
Enantioselective Separations with Supercritical Fluids - Review (2013)

This paper presents a review of the literature covering separations of enantiomers achieved with supercritical fluids. Supercritical fluid chromatography (SFC) is the main technique represented but chiral extraction (chiral SFE) and simulated moving bed (SMB) are also present. First of all, a historical view of the technique is presented. Then stationary phases, mobile phases and operating conditions are discussed, with a particular focus on the effect of operating parameters on the resolution. Detection issues are presented. The interest of SFC for screening methods and for the preparative scale is demonstrated. Comparison with other chromatographic techniques, namely gaseous-phase chromatography (GC) and high-performance liquid chromatography (HPLC) is provided. While the pharmaceutical industry is the principal application area of enantioselective separations, other examples with agrochemicals or fragrances are also presented. Foreword: This article focuses on main developments in the field of chiral separations with supercritical fluid chromatography and related techniques, as well as representative applications. It is not intended to be a comprehensive review of all papers published on the topic of chiral separations with supercritical fluids. However, it is believed that the publications mentioned here are representative of the evolution of the technique over more than 25 years of use. Several excellent reviews covering other aspects of chiral separations and/or supercritical fluid chromatography are also mentioned where appropriate. Keywords: Chiral resolution, chiral stationary phases, enantiomer separation, packed column, simulated moving bed, supercritical fluid chromatography.
New approaches to the study of sepsis (2012)

Models of sepsis have been instructive in understanding the sequence of events in animals and, to an extent, in humans with sepsis. Events developing early in sepsis suggest that a hyperinflammatory state exists, accompanied by a buildup of oxidants in tissues reflective of a redox imbalance. Development of immunosuppression and degraded innate and adaptive immune responses are well-established complications of sepsis. In addition, there is robust activation of the complement system, which contributes to the harmful effects of sepsis. These events appear to be associated with development of multiorgan failure. The relevance of animal models of sepsis to human sepsis and the failure of human clinical trials are discussed, together with suggestions as to how clinical trial design might be improved.
A Variational Framework for Multiregion Pairwise-Similarity-Based Image Segmentation (2008)

Variational cost functions that are based on pairwise similarity between pixels can be minimized within level set framework resulting in a binary image segmentation. In this paper we extend such cost functions and address multi-region image segmentation problem by employing a multi-phase level set framework. For multi-modal images cost functions become more complicated and relatively difficult to minimize. We extend our previous work, proposed for background/foreground separation, to the segmentation of images in more than two regions. We also demonstrate an efficient implementation of the curve evolution, which reduces the computational time significantly. Finally, we validate the proposed method on the Berkeley Segmentation Data Set by comparing its performance with other segmentation techniques.
Risk factors for opioid-induced respiratory depression in surgical patients: a systematic review and meta-analyses (2018)

Patients with cardiac, respiratory disease and/or obstructive sleep apnoea were at increased risk for OIRD. Patients with postoperative OIRD received higher doses of morphine equivalent daily dose.
Shape-selective targeting of DNA by phenanthrenequinone diiminerhodium(III) photocleaving agents (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShape-selective targeting of DNA by phenanthrenequinone diiminerhodium(III) photocleaving agentsAnna Marie Pyle, Eric C. Long, and Jacqueline K. BartonCite this: J. Am. Chem. Soc. 1989, 111, 12, 4520–4522Publication Date (Print):June 1, 1989Publication History Published online1 May 2002Published inissue 1 June 1989https://pubs.acs.org/doi/10.1021/ja00194a070https://doi.org/10.1021/ja00194a070research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Temperature monitoring in laser assisted polymer bonding for MEMS packaging using a thin film sensor array (2009)

Laser assisted polymer bonding is a novel technique for MEMS packaging, which can offer a short bonding time and reduce the thermally induced stress during the packaging process. However, due to the localised nature of the temperature rise, it is difficult to monitor the temperature change precisely during the bonding process using the conventional methods. In this paper, the development of thin film miniature temperature sensor arrays is presented for in-situ temperature monitoring in the laser assisted polymer bonding process. A high-power fibre-coupled diode laser at the wavelength of 970 nm was used as the heat source for benzocyclobutene (BCB) bonding/curing in conjunction with novel beam forming optics that allows selective illumination of the substrates to be joined. Instead of using infrared detectors and temperature-sensitive paints in our previous work, thin film microsensor arrays were designed and fabricated on both glass and silicon substrates for obtaining the precise in-situ temperature change and the thermal distribution during the laser bonding process. The minimum track width of a meander sensor in the array was 3 mum resulting in a foot print of only 250 mum times 240 mum for the smallest sensor. The key parameters of the laser bonding process, such as laser beam profile, power and the resultant thermal responses, were investigated as well as the effect of the thermal arrangement underneath the substrate assembly.
The pattern of energy metabolism in the mouse oöcyte and zygote. (1967)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Polyphenolic content and their antioxidant activity in leaf extract of sweet potato (Ipomoea batatas) (2012)

Nowadays, phytochemicals and antioxidants in plants are raising interest in consumers for their roles in the maintenance of human health. Phenolics and flavonoids are known for their health-promoting properties due to protective effects against cardiovascular disease, cancers and other disease. In this study, total phenolic (TP), total flavonoids (TF) and antioxidant activities of the six different varieties of sweet potato (Ipomoea batatas) leaf extracts were determined. TP content varied from 4.47±1.88 to 8.11±2.11 mg/g DW in the leaf extracts and high content of TP was observed in Vardaman variety. TF content in the extracts ranged from 1.87±0.84 and 3.95±0.91 mg/g DW and Bush Porto Rico variety showed highest content. The antioxidant activity determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH) and ferric reduction antioxidant power (FRAP) showed high activities (IC50value of 184.3 µg/mL) in the leaves of Vardaman variety while the Centennial variety showed the lowest activity (IC50=450.46 µg/ml). Antioxidant activity was highly correlated with TP content (R2=0.827, P<0.001) while, no significant correlation was observed between TF content and antioxidant activity (R2=0.0448). Therefore, the total phenolic content could be served as a useful indicator for the antioxidant activities of sweet potatoes.This study validated the medicinal potential of the sweet potatoes leaf.

	 

	Key words: Ipomoea batatas, total phenolic (TP), total flavonoids (TF), 1,1-diphenyl-2-picryl hydrazyl (DPPH) assays.
Chronic Nonparoxysmal Sinus Tachycardia in Otherwise Healthy Persons (1979)

Seven patients had chronic, unexplained, nonparoxysmal sinus tachycardia. The clinical, electrocardiographic, and electrophysiologic characteristics of these cases are described. In each case electrocardiographic and electrophysiologic observations suggested that tachycardia was nonparoxysmal and due to increased automaticity of the sinus node (or of an automatic atrial focus located very near the sinus node). The mechanisms of increased sinus node automaticity in these patients were explored using drugs affecting the autonomic nervous system. In each patient these studies suggested a defect in either sympathetic or vagal nerve control of resting heart rate, with or without an abnormality of intrinsic heart rate. Data are also presented on baroreceptor reflex arc function in these patients.
Magnetic Bearing Design for Reduced Power Consumption (1996)

Magnetic bearings have relatively low power consumption compared to fluid film and rolling element bearings. They are now candidates for supporting gas turbines and aeropropulsion engines. This paper describes the design and construction of permanent magnet biased, actively controlled magnetic bearings for a flexible rotor. The rotor was originally supported in fluid film bearings consuming as much as 3000 watts of power. For the magnetic bearing, both permanent magnets and electromagnets are used in a configuration which effectively provides the necessary fluxes in the appropriate air gaps to support the rotor. The theoretical development related to the bearing design is presented along with some experimental performance results. The results include measurements of power consumption, load capacity, bearing linearized coefficients, and the dynamic response of the rotor. The measured total power consumption, excluding shaft losses, was 210 watts in the permanent magnet biased bearing.
From Graphite to Graphene Oxide and Graphene Oxide Quantum Dots (2017)

Many methods have been reported for synthesizing graphene oxide (GO) and graphene oxide quantum dots (GOQDs) where a tedious operational procedure and long reaction time are generally required. Herein, a facile one-pot solvothermal method that allows selective synthesis of pure GO and pure GOQDs, respectively is demonstrated. What is more, the final product of either GO or differently sized GOQDs can be easily controlled by adjusting the reaction temperatures or reactant ratios, which is also feasible when enlarged to gram scale. The 2.5 nm GOQDs show excellent photoluminescence that can be utilized for bioimaging or distinctive detection of Eu<sup>3+</sup> and Tb<sup>3+</sup> from their respective mixtures with other rare earth and/or transition metal ions, at sub-ppm level.