gebhart/patrepeval huggingface dataset:
Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells (2001)

The PHD fingers of the human MLL and Drosophila trx proteins have strong amino acid sequence conservation but their function is unknown. We have determined that these fingers mediate homodimerization and binding of MLL to Cyp33, a nuclear cyclophilin. These two proteins interact in vitro and in vivo in mammalian cells and colocalize at specific nuclear subdomains. Overexpression of the Cyp33 protein in leukemia cells results in altered expression of HOX genes that are targets for regulation by MLL. These alterations are suppressed by cyclosporine and are not observed in cell lines that express a mutant MLL protein without PHD fingers. These results suggest that binding of Cyp33 to MLL modulates its effects on the expression of target genes.
Radiation boundary conditions for the numerical simulation of waves (1999)

We consider the efficient evaluation of accurate radiation boundary conditions for time domain simulations of wave propagation on unbounded spatial domains. This issue has long been a primary stumbling block for the reliable solution of this important class of problems. In recent years, a number of new approaches have been introduced which have radically changed the situation. These include methods for the fast evaluation of the exact nonlocal operators in special geometries, novel sponge layers with reflectionless interfaces, and improved techniques for applying sequences of approximate conditions to higher order. For the primary isotropic, constant coefficient equations of wave theory, these new developments provide an essentially complete solution of the numerical radiation condition problem.
Polymer-based microfluidic devices for biomedical applications (2003)

Two types of Microfluidic bioanalytical systems were designed and fabricated in polymer substrates using the LIGA process. A continuous flow polymerase chain reaction (CFPCR) Microfluidic device was fabricated in polycarbonate (PC), which utilized isothermal zone and shuttling the sample through each zone to achieve amplification. A 20-cycle PCR amplification of a fragment of a plasmid DNA template was achieved in 5.3 min. The results were comparable to those obtained in commercial laboratory-scale PCR system. The second system consisted of a microchip contating a low-density array assembled into the Microfluidic channel, which was hot-embossed in poly(methyl methacrylate) (PMMA). The detection of low-abundant mutations in gene fragments (<i>K-ras</i>) that carry point mutations with high diagnostic value for colorectal cancer was successfully performed. The array accessed microfluidics in order to enhance the kinetic associated with hybridization.
Increasing quality by online control of the cavity pressure (2004)

An online cavity pressure controller for injection molding has been developed. During the filling phase a constant gradient of the cavity pressure is realized, in the holding pressure phase the cavity pressure is calculated with a pvT-optimization. Controlling the cavity pressure results in higher quality and constant molded part properties.
A scatter-corrected list-mode reconstruction and a practical scatter/random approximation technique for dynamic PET imaging (2007)

We describe an ordinary Poisson list-mode expectation maximization (OP-LMEM) algorithm with a sinogram-based scatter correction method based on the single scatter simulation (SSS) technique and a random correction method based on the variance-reduced delayed-coincidence technique. We also describe a practical approximate scatter and random-estimation approach for dynamic PET studies based on a time-averaged scatter and random estimate followed by scaling according to the global numbers of true coincidences and randoms for each temporal frame. The quantitative accuracy achieved using OP-LMEM was compared to that obtained using the histogram-mode 3D ordinary Poisson ordered subset expectation maximization (3D-OP) algorithm with similar scatter and random correction methods, and they showed excellent agreement. The accuracy of the approximated scatter and random estimates was tested by comparing time activity curves (TACs) as well as the spatial scatter distribution from dynamic non-human primate studies obtained from the conventional (frame-based) approach and those obtained from the approximate approach. An excellent agreement was found, and the time required for the calculation of scatter and random estimates in the dynamic studies became much less dependent on the number of frames (we achieved a nearly four times faster performance on the scatter and random estimates by applying the proposed method). The precision of the scatter fraction was also demonstrated for the conventional and the approximate approach using phantom studies.
Cation/Anion Associations in Ionic Liquids Modulated by Hydration and Ionic Medium (2011)

In order to understand the unique solvation and conduction properties of ionic liquids (ILs), we explore their interionic associations modulated by hydration level and ionic medium. Pulsed-field-gradient NMR allows sensitive measurement of separate cation and anion diffusion coefficients, which combine to reflect ionic aggregation. With increasing hydration of ILs, the anomalous ratio of cation to anion diffusion coefficients reverses, then plateaus to values consistent with expected hydrodynamic radii ratios (r(cation)/r(anion) = 1.4 for [C(2)mim][BF(4)]). When ILs diffuse inside an ionic polymer, ion associations are modulated by ionic interactions between mobile cations and anions, and drag from fixed -SO(3)(-) lining the polymer's hydrophilic channels. Surprisingly, cations diffuse substantially faster (≤3×) at low hydration inside membranes, revealing prevalent anionic aggregates. At high hydration, isolated anions diffuse faster (≤4×) than cations. Probing ionic interactions provides pivotal insight into these subtle fluids, with quantitative implications for electrolyte applications such as batteries and "artificial muscle" mechanical actuators.
Adaptive optics retinal imaging reveals S-cone dystrophy in tritan color-vision deficiency (2007)

Tritan color-vision deficiency is an autosomal dominant disorder associated with mutations in the short-wavelength-sensitive- (S-) cone-pigment gene. An unexplained feature of the disorder is that individuals with the same mutation manifest different degrees of deficiency. To date, it has not been possible to examine whether any loss of S-cone function is accompanied by physical disruption in the cone mosaic. Two related tritan subjects with the same novel mutation in their S-cone-opsin gene, but different degrees of deficiency, were examined. Adaptive optics was used to obtain high-resolution retinal images, which revealed distinctly different S-cone mosaics consistent with their discrepant phenotypes. In addition, a significant disruption in the regularity of the overall cone mosaic was observed in the subject completely lacking S-cone function. These results taken together with other recent findings from molecular genetics indicate that, with rare exceptions, tritan deficiency is progressive in nature.
The Effect of TGF-β on Keloid Fibroblast Proliferation and Collagen Synthesis (1996)

Keloids are characterized by an overabundant deposition of collagen, and they recur frequently following excision. Fibroblasts isolated from keloid tissue and maintained in cell culture continue to express an increased capacity to produce collagen. In an effort to define the mechanisms responsible for keloid formation, the potential of exogenous transforming growth factor beta 1 (TGF-beta 1) to differentially affect DNA synthesis and collagen expression in cultured human fibroblasts derived from keloid or normal dermis was investigated. In this study, TGF-beta 1 at a concentration of 5.0 ng/ml was found to stimulate DNA synthesis of keloid-derived fibroblasts to a greater extent than fibroblasts derived from normal dermis. With a microassay to measure levels of collagenase-digestible radiolabeled proteins, TGF-beta 1 was found to elicit a greater increase in absolute collagen synthesis in keloid-derived fibroblasts compared with fibroblasts derived from normal dermis. Examination of tRNA(pro) pool-specific activities indicated that these observed differences in rates of collagen synthesis were not the result of unequal rates of proline transport or pool size. Likewise, TGF-beta 1 did not alter the uptake of vitamin C, an essential cofactor and mediator needed for maximal collagen expression. The increase in collagen synthesis by keloid-derived fibroblasts treated with TGF-beta 1 was accompanied by a corresponding increase in procollagen type I mRNA levels, indicating that the differential response of keloid and normal dermal fibroblasts to this growth factor is occurring primarily at a pretranslational level. These results suggest a unique sensitivity of keloid fibroblasts to TGF-beta 1 and thus a possible role for this mediator in keloid pathogenesis.
Molecular Dynamics Simulation of Al2O3 Grain Boundaries with CaAl2Si2O8 as Interface Phase (2006)

Molecular dynamics simulations were performed to study interface structures between an <TEX>$Al_2O_3$</TEX> crystalline phase and a interface phase of <TEX>$CaAl_2Si_2O_8$</TEX>. We calculated atomic structures and excess interface energies in systems with different thicknesses of the interface film. It was found that excess interface energies at first readily decreased with increasing film thickness, but increased for larger thicknesses of more than 2 nm. The excess energies of <TEX>$Al_2O_3/CaAl_2Si_2O_8$</TEX> interfaces exhibit a minimum at a thickness around 1 nm. In this range of film thicknesses, the atoms in the interface film show a short-range ordered structure and slow diffusion rather than the random structure and rapid diffusion expected to an observation of an equilibrium thickness for interface films in ceramics.
Clinical and pathological study of experimentally- induced yew (Taxus baccata) poisoning in sheep (2011)

Acute yew (Taxus baccata) intoxication was induced in 7 adult sheep by oral administration of the plant materials at the dose of 2.5g/kg body weight. Blood samples for hematology and serum biochemistry were collected before and after the induced intoxication.Electrocardiography was performed using a base-apex lead. Intoxicated animals displayed lethargy, depression, bradycardia and varying intensity of heart sounds. The ECGs of intoxicated sheep showed a variety of arrhythmias and abnormalities including multifocal ventricular tachycardia, idioventricular and idiojunctinal rhythm and QRS and T widening. Four sheep died within 4-16 hours after yew administration. Significant increase of white blood cells, total neutrophil counts and serum sodium concentration were observed. Post mortem examination and histological evaluation were done with special regards on tissue changes of the myocardium and conduction system. There were hyperemia, focal hemorrhage and multifocal nonsuppurative interstitial myocarditis with mild focal cardiac muscle cell degeneration and necrosis in the affected hearts which appeared more prominent in the right atrium. Histopathological examination of cardiac conduction system also revealed moderate to severe interstitial edema with inflammation of the SA-node, AV-node, the bundle branches and His-bundle in all cases which was most severe in the AV-node and the His-bundle. Oral administration of dried leaves of T. baccata, at the dose of 2.5g/kg can induce acute toxicity, manifested clinically by a variety of cardiac arrhythmia and myocardial lesions including special conduction system in pathology.
A continuously variable digital delay element (2003)

The author describes an FIR (finite-impulse-response) filter which synthesizes a controllable delay. By changing the delay the filter has the ability to interpolate between samples in the data stream of a band-limited signal. Because high sampling rates are not required, the filter is especially suited for implementation in a digital signal processor (DSP), and has been implemented in a real-time DSP. The interpolator can be used as a practical way to reconstruct an original band limited signal from samples taken at the Nyquist rate. The variable delay filter can also be used as a more general computational element. Performance results are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Serotonin uptake inhibitors: Uses in clinical therapy and in laboratory research (1995)

Fluoxetine, zimelidine, sertraline, paroxetine, fluvoxamine, indalpine and citalopram are the selective inhibitors of serotonin uptake that have been most widely studied. Some of these compounds are or have been used clinically in the treatment of mental depression, obsessive-compulsive disorder and bulimia, and therapeutic benefit has been claimed in additional diseases as well. By blocking the membrane uptake carrier which transports serotonin from the extracellular space to inside the serotonin nerve terminals, these compounds increase extracellular concentrations of serotonin and amplify signals sent by serotonin neurons. Because serotonin neurons are widespread in the central nervous system, the functional consequences of blocking serotonin uptake are diverse, but are generally subtle. Animals treated with serotonin uptake inhibitors look normal in gross appearance, but effects such as reduced aggressive behavior, decreased food intake and altered food selection, analgesia, anticonvulsant activity, endocrine changes and neurochemical changes have been demonstrated and characterized. Serotonin uptake inhibitors have helped in revealing some dynamics of serotonin neurons; for example, when uptake is inhibited and extracellular serotonin concentration increases, presynaptic as well as postsynaptic receptors for serotonin are activated to a greater degree. A consequence of increased activation of autoreceptors on serotonin cell bodies and nerve terminals is a reduction in firing of serotonin neurons and a decrease in serotonin synthesis and release. The result is a limit on the degree to which extracellular serotonin and serotonergic neurotransmission are increased.(ABSTRACT TRUNCATED AT 250 WORDS)
Ecology of Heterotrophic Aerobic Bacteria of Playa Lakes and Microcosms (1971)

Playa lakes of the High Plains region receive runoff from well- defined watershed areas. Data are presented from a study' of two lakes and microcosms developed from the Nutrient agar plate counts of viable bac- terial populations ranged from 104 to 106/ml in the lakes and to 107/ml in the microcosms. Of 22 bacterial types isolated, 10 were actinomycetes-like and 9 of the 22 were chromogenic, gram-negative rods. No bacterial succession was observed in the lakes although a definite succession was present in the microcosms. Bacteria were apparently little affected by changes in water temperature, pH changes (from pH 7.0 to 8.2), or in water levels of the Uptake of 14C-U-glucose had value as a relative measure of heterotrophic activity and was closely related to viable plate counts of bacteria. Phytoplankton photosynthesis was negligible as based on uptake of NaH14CO3. Evidence was obtained for antibiotic production by an actino- mycete isolate. Vascular plants covered approximately 75% of the dry lake bed. Following the influx of runoff, most of these plants were degraded, in part by microbial action. Thus, a food web was initiated which supported high numbers of animals, including water fowl. The lake ecosystems are highly productive and may represent an example of detritus agriculture. The Llano Estacado of Texas features flat, windswept plains. De- pressions have formed in the plains and these are as frequent as 1 per mile2. During the spring and summer the playas receive run- off from the heavy rainfall and the resulting semi-permanent ponds are called playa lakes. Playa lakes range in size from a few to hundreds of acres and are from inches to several feet deep. The dura- tion of the lakes may be from a few days to semi-permanent. Common features of the lakes include well-defined, circular, gently sloping drainage basins and colloidal sediment bottoms which prevent seepage; thus evaporation and transpiration account for an estimated 85-90% of the water loss. Definite plant zones are typical during the growing season in temporary playas. The lakes influence the produc- tivity and ecology of the surrounding grazing or agricultural lands.
A bind RGB color image watermarking based on singular value decomposition (2010)

In this paper, we propose a novel SVD-based RGB color image watermarking, in which the watermark is assumed to be an RGB color image whose detection and extraction are performed in a blind manner. The performance of the proposed watermarking method is investigated by measuring its imperceptible and robust capabilities. For the imperceptible capability, a quantitative index, Peek Signal-to-Noise Ratio (PSNR), is employed to evaluate the difference between an original image and its corresponding watermarked image. For the robust capability, the Correlation Coefficient (CC) is also used to evaluate the similarity between the original watermark and the extracted one. Experimental results indicate that our technique is robust and produces high-quality watermarked images.
Single Sign On architecture with dynamic tokens (2004)

Single Sign On (SSO) is a useful technology that allows users to skip bothersome authentication processes during accesses to multiple services. It is particularly useful for services for mobile terminals because of their limited resources and interfaces. Some existing SSO mechanisms only verify static data such as IDs and passwords. However, we consider that it will be quite useful if they could deal with dynamic data. We propose a new SSO architecture that uses a "dynamic token" that describe dynamic data such as a payment history. The architecture introduces an additional server, named "Circulator", which distributes the latest token values to service providers. Accordingly, the providers can correctly verify the token values sent from clients. This paper proposes an efficient algorithm for Circulator to effectively visit the providers. The result of our experiment shows the efficiency of the algorithm.
Cognitive Impairment: An Increasingly Important Complication of Type 2 Diabetes: The Age, Gene/Environment Susceptibility-Reykjavik Study (2008)

Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men and women (average age = 76 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2006). Glycemic status groups included diagnosed diabetes (self-reported diabetes or diabetic medication use; n = 163 (8.5%)), undiagnosed diabetes (fasting blood glucose >or=7.0 mmol/L without diagnosed diabetes; n = 55 (2.9%)), and impaired fasting glucose (fasting blood glucose 5.6-6.9 mmol/L; n = 744 (38.8%)). Composites of memory, processing speed (PS), and executive function were constructed from a neuropsychological battery. Linear regression was used to investigate cross-sectional differences in cognitive performance between glycemic groups, adjusted for demographic and health factors. Persons with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes duration of >or=15 years was associated with significantly poorer PS and executive function. Undiagnosed diabetics had slower PS (beta = -0.22; P < 0.01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance.
Reactivity of trimethylaluminum with (C5Me5)2Sm(THF)2: synthesis, structure, and reactivity of the samarium methyl complexes (C5Me5)2Sm[(.mu.-Me)AlMe2(.mu.-Me)]2Sm(C5Me5)2 and (C5Me5)2SmMe(THF) (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactivity of trimethylaluminum with (C5Me5)2Sm(THF)2: synthesis, structure, and reactivity of the samarium methyl complexes (C5Me5)2Sm[(.mu.-Me)AlMe2(.mu.-Me)]2Sm(C5Me5)2 and (C5Me5)2SmMe(THF)William J. Evans, L. R. Chamberlain, Tamara A. Ulibarri, and Joseph W. ZillerCite this: J. Am. Chem. Soc. 1988, 110, 19, 6423–6432Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/ja00227a023https://doi.org/10.1021/ja00227a023research-articleACS PublicationsRequest reuse permissionsArticle Views645Altmetric-Citations182LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Annexin A1 Interaction with the FPR2/ALX Receptor (2012)

Understanding how proresolving agonists selectively activate FPR2/ALX is a crucial step in the clarification of proresolution molecular networks that can be harnessed for the design of novel therapeutics for inflammatory disease. FPR2/ALX, a G protein-coupled receptor belonging to the formyl peptide receptor (FPR) family, conveys the biological functions of a variety of ligands, including the proresolution mediators annexin A1 (AnxA1) and lipoxin A(4), as well as the activating and proinflammatory protein serum amyloid A. FPR2/ALX is the focus of intense screening for novel anti-inflammatory therapeutics, and the small molecule compound 43 was identified as a receptor ligand. Here, we used chimeric FPR1 and FPR2/ALX clones (stably transfected in HEK293 cells) to identify the N-terminal region and extracellular loop II as the FPR2/ALX domain required for AnxA1-mediated signaling. Genomic responses were also assessed with domain-specific effects emerging, so the N-terminal region is required for AnxA1 induction of JAG1 and JAM3, whereas it is dispensable for modulation of SGPP2. By comparison, serum amyloid A non-genomic responses were reliant on extracellular loops I and II, whereas the small molecule compound 43 activated extracellular loop I with downstream signaling dependent on transmembrane region II. In desensitization experiments, the N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes.