gebhart/patrepeval huggingface dataset:
Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study (1995)

The pharmacokinetics, safety, and efficacy in marrow transplantation of FK506-based immunosuppression for graft-versus-host disease (GVHD) prophylaxis was evaluated in an open label pilot study of 18 patients. Patients more than 12 years of age (median, 35 years; range, 15 to 50 years) with advanced hematologic malignancies receiving HLA-matched sibling marrow grafts were randomized to receive FK506 alone, FK506 and methotrexate (MTX), or FK506 and methyl-prednisolone. Of 17 evaluable patients, all had evidence of sustained marrow engraftment. The median time to an absolute neutrophil count of greater than 500/microL was 15 days for patients receiving FK506 alone or FK506 plus methylprednisolone and 23 days for FK506 plus short MTX. Pharmacokinetic studies did not show any significant difference in clearance of FK506 when administered alone or in combination with methylprednisolone or MTX. The mean bioavailability after oral administration in these same three groups was 0.49 +/- 0.1, 0.27 +/- 0.12, and 0.16 +/- 0.08, respectively (P = .003). The decrease in bioavailability may have resulted from an exacerbation of radiation-induced gastroenteritis by MTX. The most significant adverse effect associated with the administration of FK506 was nephrotoxicity, which occurred in 14 of 18 patients (78%). The mean glomerular filtration rate, determined by clearance of (99MTc)DTPA, decreased to 56% (+/- 18%) of the pretransplant baseline level by week 8 (P = .002). Eight of 18 patients (44%) developed grades II-IV acute GVHD, predominantly of the skin and gastrointestinal tract. The actuarial probability of transplant-related mortality during the first 100 days was 24%. The actuarial probability of 1-year disease-free survival was 39%. In conclusion, although bioavailability of FK506 may be affected in patients receiving MTX, this study suggests that FK506 may have a role in the management of patients after allogeneic marrow transplantation.
Persistence of Neutralizing Antibody for a Year following Vaccination of Monkeys with Lansing Poliomyelitis Virus. (1950)

The level of serum neutralizing antibody to Lansing poliomyelitis virus has been followed in three rhesus monkeys. After a course of intramuscular vaccination with active virus, which rendered the animals resistant to intracerebral challenge with a large dose of virus, they received a final vaccinating dose intramuscularly. During the year following this final dose, no more vaccine was given. Their antibody levels, optimum at the start, fell gradually during the first 8 months, then remained at a moderate level for the last 4 months. At the end of the year, a booster dose of active virus given intramuscularly raised their antibody to optimum levels once more, from which they gradually drifted downward.
Apexin, an acrosomal pentaxin. (1994)

We report the initial biochemical characterization and the primary structure of a guinea pig sperm acrosomal pentaxin (apexin). Pentaxins are a family of penta- or decameric serum proteins that includes serum amyloid protein and C-reactive protein. Apexin consists of disulfide-linked 50-kDa subunits that give rise to an oligomeric protein. Apexin and a sperm protein related to complement receptors coelute with affinity-purified fertilin (PH-30), a potential sperm-egg membrane fusion protein. However, no evidence for a functional association of apexin with fertilin was found. Apexin is localized to the acrosome of mature guinea pig sperm and is thus the first pentaxin for which a defined intracellular localization has been reported. Whereas the C-terminal portion of apexin is clearly related to serum pentaxins, the N-terminal domain shows no strong homology to other known proteins. Northern blot analysis of different tissues revealed expression in the testis. Apexin is distinct from the pentaxins serum amyloid protein and C-reactive protein and may have evolved to perform functions other than those performed by serum pentaxins, such as intracellular protein sorting to the acrosome.
Modality-specific temporal constraints for state-dependent interval timing (2018)

The ability to discriminate temporal intervals in the milliseconds-to-seconds range has been accounted for by proposing that duration is encoded in the dynamic change of a neuronal network state. A critical limitation of such networks is that their activity cannot immediately return to the initial state, a restriction that could hinder the processing of intervals presented in rapid succession. Empirical evidence in the literature consistently shows impaired duration discrimination performance for 100 ms intervals demarked by short auditory stimuli immediately preceded by a similar interval. Here we tested whether a similar interference is present with longer intervals (300 ms) demarked either by auditory or by visual stimuli. Our results show that while temporal estimates of auditory stimuli in this range are not affected by the interval between them, duration discrimination with this duration is significantly impaired with visual intervals presented in rapid succession. The difference in performance between modalities is overall consistent with state-dependent temporal computations, as it suggests that the limits due to slow neuronal dynamics greatly depends on the sensory modality with which the intervals are demarked, in line with the idea of intrinsic, modality-specific neural mechanisms for interval timing.
Rethinking Desalinated Water Quality and Agriculture (2007)

Damage to crops after irrigation with extremely pure water from the world9s largest reverse-osmosis desalination plant reveals a need for revised treatment standards.
Increase in endogenous antioxidant enzymes protects hearts against reperfusion injury (1993)

Coarctation of the abdominal aorta in rats for 10 wk increased the heart weight-to-body weight ratio by 36% and peak left ventricular systolic pressure by 75%; there was no apparent change in the end-diastolic pressure, and animals did not show any clinical signs of heart failure. These hypertrophied (H) hearts showed increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) with no change in catalase. Lipid peroxide content as indicated by the malondialdehyde (MDA) level was lower in H hearts. There was no apparent difference in either Na+ and Ca2+ content or high-energy phosphates between sham (S) and H hearts. Control and H hearts were subjected to 10 min of ischemia (I) and 15 min of reperfusion (R). Contractile failure and rise in resting tension due to I, in both S and H hearts, were comparable. On reperfusion, H hearts showed better recovery of the developed force and resting tension as well as reduced incidence of arrhythmias when compared with corresponding S hearts. Both SOD and GSHPx activities were depressed due to I-R, but these activities were significantly higher in reperfused H hearts. Reperfused H hearts also showed a better maintenance of the ultrastructure and Na+ and Ca2+ contents, recovery of high-energy phosphates, and reduced MDA levels compared with S hearts. Supplementation of the perfusion medium with SOD (120 U/ml) and catalase (80 U/ml) significantly attenuated the I-R injury in S hearts, and the response in many ways was comparable to H hearts. The study documents the therapeutic potential of increased myocardial endogenous antioxidants against oxidative stress.
RENAS: Reinforced Evolutionary Neural Architecture Search (2019)

Neural Architecture Search (NAS) is an important yet challenging task in network design due to its high computational consumption. To address this issue, we propose the Reinforced Evolutionary Neural Architecture Search (RENAS), which is an evolutionary method with reinforced mutation for NAS. Our method integrates reinforced mutation into an evolution algorithm for neural architecture exploration, in which a mutation controller is introduced to learn the effects of slight modifications and make mutation actions. The reinforced mutation controller guides the model population to evolve efficiently. Furthermore, as child models can inherit parameters from their parents during evolution, our method requires very limited computational resources. In experiments, we conduct the proposed search method on CIFAR-10 and obtain a powerful network architecture, RENASNet. This architecture achieves a competitive result on CIFAR-10. The explored network architecture is transferable to ImageNet and achieves a new state-of-the-art accuracy, i.e., 75.7% top-1 accuracy with 5.36M parameters on mobile ImageNet. We further test its performance on semantic segmentation with DeepLabv3 on the PASCAL VOC. RENASNet outperforms MobileNet-v1, MobileNet-v2 and NASNet. It achieves 75.83% mIOU without being pretrained on COCO.
Vertical Position Control for Top Tensioned Riser With Active Heave Compensator (2011)

The top and bottom angles of a marine riser are of crucial importance during e.g. drilling and workover operations. A vertical position control with active heave compensator (AHC) is proposed to maintain the safety of the riser when subjected to environmental excitations. The possibility of reducing the maximum angular response level by adjusting the vertical rod position by means of an active heave compensator is investigated with a positioning algorithm based on adaptive backstepping. Riser top and bottom angles are dealt with by the algorithm in order to minimize both angles.
Induction of biologically active IL-1 beta-converting enzyme and mature IL-1 beta in human keratinocytes by inflammatory and immunologic stimuli (1997)

IL-1beta, a major mediator of inflammatory and immunologic skin disease, undergoes post-translational site-specific cleavage by a novel cysteine protease termed IL-1beta-converting enzyme (ICE). Although in human skin keratinocytes produce significant amounts of the 31-kDa IL-1beta precursor protein, they fail under nonpathologic conditions to convert it to the 17.5-kDa bioactive form. In this study, we examined whether haptens and inflammatory agents might serve as stimuli for ICE activity in human keratinocytes, and, if so, whether ICE activity might precipitate enzymatic processing of IL-1beta to its 17.5-kDa form. Baseline levels of ICE mRNA were detected in keratinocyte cultures devoid of Langerhans cells and were up-regulated by nontoxic concentrations of the reactive hapten urushiol and by the irritant chemicals sodium lauryl sulfate and PMA. Although untreated keratinocytes expressed the 31-kDa form of the protein, 17.5-kDa IL-1beta was easily detected in keratinocytes and keratinocyte supernatants treated with either urushiol or the irritant chemicals. Enzymatic conversion from the 31-kDa to the 17.5-kDa form of IL-1beta was blocked by addition of a highly specific aldehyde inhibitor that contained a tetrapeptide recognition sequence specific for ICE, but not by an aldehyde inhibitor of a related ICE-like cysteine protease. Induction of IL-1beta-converting enzyme by immunologic and inflammatory stimuli may be one of the key regulatory elements in the pathogenesis of allergic and irritant contact hypersensitivity.
Passive mode locking of a diode-end-pumped Nd:GdVO_4 laser with a semiconductor saturable absorber mirror (2003)

We report an end-pumped and passive mode-locking all-solid-state laser. The laser consists of a Nd:GdVO4 crystal and a linear resonator with a semiconductor saturable absorber mirror that yield mode locking. We achieved stable continuous-wave mode locking with an 8-ps pulse duration at a 154-MHz repetition rate. The average output power was 600 mW with 4 W of pump power. To our knowledge this is the first report of the use of a Nd:GdVO4 crystal for mode locking with a semiconductor saturable absorber mirror.
A Novel Degradation Pathway of Tissue Factor Pathway Inhibitor: Incorporation Into Fibrin Clot and Degradation by Thrombin (1997)

Tissue factor pathway inhibitor (TFPI) is a Kunitz-type protease inhibitor with three tandem inhibitory domains (K1, K2, and K3) that regulates the initial reactions of the extrinsic blood coagulation pathway through K1 and K2. In the present study, the effect of thrombin on TFPI in a purified system was first examined using recombinant TFPI from Chinese hamster ovary (CHO) cells. TFPI was inactivated by thrombin with cleavage of three peptide bonds, Lys 254-Thr 255 in the C-terminal basic region, Arg 107-Gly 108 (reactive site toward factor Xa in K2), and Lys 86-Thr 87 between K1 and K2. Then, degradation of radiolabeled TFPI by thrombin was examined in two systems: (1) mixed with plasma and then tissue factor (TF) and calcium ion, and (2) mixed with fibrinogen and then thrombin. TFPI degradation was detected in serum from normal plasma and more extensively from anti-thrombin (AT)-depleted plasma by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Significant radioactivity was found in the clot after coagulation of the plasma, which decreased after 20 hours' incubation. These changes were more prominent in AT-depleted plasma than in normal plasma. When TFPI lacking the C-terminal basic region was used instead of full-length TFPI, most of the radioactivity was found in serum rather than in fibrin clots. Incorporation of TFPI into the fibrin clot was prevented by a synthetic C-terminal peptide of TFPI. Similar results were obtained after mixing radiolabeled TFPI with fibrinogen and then thrombin in the presence of calcium ion or EDTA. These results demonstrate a novel degradation pathway of TFPI, ie, incorporation into fibrin via the C-terminal basic region and degradation by thrombin (possibly fibrin-bound thrombin).
Prenatal Human Immunodeficiency Virus Testing and Patient Management by Obstetricians in a HighSeroprevalence Community (1994)

We concluded that obstetricians in this community have largely accepted routinely offered prenatal testing and risk assessment, but they have assumed a relatively small role in risk reduction counseling and treatment.
Insights into the Formation of Borabenzene Adducts via Ligand Exchange Reactions and TMSCl Elimination from Boracyclohexadiene Precursors (2014)

The bonding properties of borabenzene with various neutral Lewis bases have been investigated. 1-Chloro-4-isopropyl-2-(trimethylsilyl)-2,4-boracyclohexadiene reacts with a number of Lewis bases—notably pyridine, PMe3, PCy3, and PPh3—to afford 4-isopropylborabenzene–base adducts. These adducts can undergo ligand exchange to afford new borabenzene complexes. The scope and mechanism of the reaction, as well as the steric and electronic properties of different adducts, were studied experimentally and computationally.
A Case for MLP-Aware Cache Replacement (2006)

Performance loss due to long-latency memory accesses can be reduced by servicing multiple memory accesses concurrently. The notion of generating and servicing long-latency cache misses in parallel is called Memory Level Parallelism (MLP). MLP is not uniform across cache misses - some misses occur in isolation while some occur in parallel with other misses. Isolated misses are more costly on performance than parallel misses. However, traditional cache replacement is not aware of the MLP-dependent cost differential between different misses. Cache replacement, if made MLP-aware, can improve performance by reducing the number of performance-critical isolated misses. This paper makes two key contributions. First, it proposes a framework for MLP-aware cache replacement by using a runtime technique to compute the MLP-based cost for each cache miss. It then describes a simple cache replacement mechanism that takes both MLP-based cost and recency into account. Second, it proposes a novel, low-hardware overhead mechanism called Sampling Based Adaptive Replacement (SBAR), to dynamically choose between an MLP-aware and a traditional replacement policy, depending on which one is more effective at reducing the number of memory related stalls. Evaluations with the SPEC CPU2000 benchmarks show that MLP-aware cache replacement can improve performance by as much as 23%.
Antidiarrheal activity of α-terpineol in mice (2018)

Diarrhea is one of the leading causes of infant death in the world accounting for high child mortality rate. It is also present in different pathophysiologies related to several etiological agents. The aim of this study is to investigate the antidiarrheal effect of α -Terpineol (α-TPN) in different diarrhea models in rodents. The antidiarrheal effect of α-TPN in the treatment of acute diarrhea and enteropooling induced by castor oil or PGE<sub>2</sub> in Swiss mice pretreated orally with saline (NaCl 0.9%), Loperamide (5 mg/kg) and α-TPN (6.25, 12.5, 25 and 50 mg/kg) was analyzed. Additionally, parameters of severity, total weight of faeces and post-treatment for 4 h were evaluated. Modulation of the opioid and cholinergic pathways was performed and intestinal transit model using activated charcoal as marker was also used. The effect of α-TPN on secretory diarrhea was investigated using the model of fluid secretion in intestinal loops isolated from cholera toxin-treated mice. α-TPN showed antidiarrheal effect (*p < 0.05), reducing the total stool amount (*55%, *48%, *44%, *24%) and diarrheal (*47%, *66%; *56%, 10%) respectively for the doses tested. All doses investigated in the enteropooling test presented significant changes (*46%, *78%, *66%, *41% respectively) in relation to the control. α-TPN through the muscarinic pathway reduced the gastrointestinal transit (*31%), besides inhibiting PGE<sub>2</sub>-induced diarrhea (*39%). α-TPN also reduced fluid formation and loss of Cl<sup>-</sup> ions, by interacting directly with GM1 receptors and cholera toxin, thus increasing the uptake of intestinal fluids. The results suggest an anti-diarrheal activity of α-TPN due to its anticholinergic action, ability to block PGE<sub>2</sub> and GM1 receptors and interaction with cholera toxin in secretory diarrhea, making it a promising candidate drug for the treatment of diarrheal diseases.
Bioavailability of Octamethylcyclotetrasiloxane (D4) After Exposure to Silicones by Inhalation and Implantation (2001)

We developed a physiologically based pharmacokinetic (PBPK) model to predict the target organ doses of octamethylcyclotetrasiloxane (D 4 ) after intravenous (IV), inhalation, or implantation exposures. The model used 14 C-D 4 IV disposition data in rats to estimate tissue distribution coefficients, metabolism, and excretion parameters. We validated the model by comparing the predicted blood and tissues concentrations of D 4 after inhalation to experimental results in both rats and humans. We then used the model to simulate D 4 kinetics after single and/or repeated D 4 exposures in rats and humans. The model predicted bioaccumulation of D 4 in fatty tissues (e.g., breast), especially in women. Because of its high lipid solubility (Log P oct/water = 5.1), D 4 persisted in fat with a half life of 11.1 days after inhalation and 18.2 days after breast implant exposure. Metabolism and excretion remained constant with repeated exposures, larger doses, and/or different routes of exposure. The accumulation of D 4 in fatty tissues should play an important role in the risk assessment of D 4 especially in women exposed daily to multiple personal care products and silicone breast implants.
The G401 cell line, utilized for studies of chromosomal changes in Wilms' tumor, is derived from a rhabdoid tumor of the kidney. (1993)

The histology, ultrastructure, and messenger RNA expression of heterotransplants derived from the G401 cell line (American Type Culture Collection) have been characterized by comparison with Wilms' and rhabdoid tumors of the kidney. This analysis illustrates that the properties of G401 heterotransplant were consistent with a rhabdoid phenotype rather than that of a Wilms' tumor. The G401 cell line has been utilized in recent experiments to demonstrate the central role of chromosome 11 in Wilms' tumor. However, the present results suggest that these experiments may be more relevant to define the involvement of chromosome 11 in rhabdoid tumor of the kidney, a malignancy distinct from Wilms' tumor. This is clinically relevant since the rhabdoid tumor of the kidney is very aggressive and associated with an extremely poor prognosis.
Synthesis of IB-01211, a Cyclic Peptide Containing 2,4-Concatenated Thia- and Oxazoles, via Hantzsch Macrocyclization (2007)

[structure: see text] An efficient and versatile convergent synthesis of IB-01211 based on a combination of peptide and heterocyclic chemistry is described. The key step in the synthesis is macrocyclization through intramolecular Hantzsch formation of the thiazole ring. Dehydration of a free primary alcohol to furnish the exocyclic methylidene present in the natural product was applied during the macrocyclization.
Xenogeneic Spermatogenesis Following Transplantation of Hamster Germ Cells to Mouse Testes1 (1999)

It was recently demonstrated that rat spermatogenesis can occur in the seminiferous tubules of an immunodeficient recipient mouse after transplantation of testis cells from a donor rat. In the present study, hamster donor testis cells were transplanted to mice to determine whether xenogeneic spermatogenesis would result. The hamster diverged at least 16 million years ago from the mouse and produces spermatozoa that are larger than, and have a shape distinctly different from, those of the mouse. In four separate experiments with a total of 13 recipient mice, hamster spermatogenesis was identified in the testes of each mouse. Approximately 6% of the tubules examined demonstrated xenogeneic spermatogenesis. In addition, cryopreserved hamster testis cells generated spermatogenesis in recipients. However, abnormalities were noted in hamster spermatids and acrosomes in seminiferous tubules of recipient mice. Hamster spermatozoa were also found in the epididymis of recipient animals, but these spermatozoa generally lacked acrosomes, and heads and tails were separated. Thus, defects in spermiogenesis occur in hamster spermatogenesis in the mouse, which may reflect a limited ability of endogenous mouse Sertoli cells to support fully the larger and evolutionarily distant hamster germ cell. The generation of spermatogenesis from frozen hamster cells now adds this species to the mouse and rat, in which spermatogonial stem cells also can be cryopreserved. This finding has immediate application to valuable animals of many species, because the cells could be stored until suitable recipients are identified or culture techniques devised to expand the stem cell population.
Measurement of ATP production in mitochondrial disorders (2006)

Mitochondrial diseases are a heterogeneous group of disorders caused by mutations in both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA). Mitochondrial disease leads to impaired respiratory chain function and reduced ATP production. The aim of this study was to compare disturbances in mitochondrial function by measuring ATP synthesis in fibroblasts derived from patients with nDNA and mtDNA defects. Skin fibroblasts derived from 22 patients with either nDNA-related disorders (n = 8) or mtDNA-related disorders (n = 14) were analysed. ATP synthesis was markedly decreased in fibroblasts derived from patients with nDNA-related disorders but only variably so in patients with mtDNA mutations. In fibroblasts with the MELAS 3243A > G mutation, ATP synthesis correlated with mutant load. We believe that the observed differences in ATP production between cell lines derived from patients with nDNA-related disorders and mtDNA-related disorders may help in the assessment of patients with undiagnosed mitochondrial disease. The clinical comparisons observed in patients with nDNA- and mtDNA-related disorders may be explained by differences in the disturbance of ATP synthesis measured in the two conditions.