gebhart/patrepeval huggingface dataset:
Artificial Intelligence-Based Cardiac Rehabilitation Therapy Exercise Recommendation System (2018)

Cardiovascular disease is one of the leading causes of death in modern society. There are many factors that must be taken into consideration when analyzing cardiovascular disease (CVD), such as a patient's quality of life, general well-being, diet, lifestyle, psychosocial effects, medical costs, and many other factors. Pharmaceutical interventions are the primary method of treating heart conditions, however, one of the most popular and widespread methods of treatment which often augments medication is Cardiac Rehabilitation Therapy (CRT). CRT programs have been shown to be an effective secondary prevention method for CVD. It can help reduce patient risk, as well as improve their recovery and overall health outcomes. In this paper, we propose a recommendation system for patient decision support, and a computational model for cardiac rehabilitation planning, in order to personalize and optimize the physical exercise therapy plan offered to patients, to meet their goals and needs. We tested our proposed model against randomly generated exercise plans, and found that our model was able to find the optimal therapy plan with a 43% higher rate of success on average relative to the random model, with regards to meeting patients' goals and needs. We believe our patient-centered solution to CRT will improve patient satisfaction, quality of life, and help reduce costs through improved efficacy and adherence to the therapy program, along with improved post-therapy cardiac health management.
Sol-gel-derived <inline-formula><math display="inline" overflow="scroll"><mn>4</mn><mo>×</mo><mn>4</mn></math></inline-formula> multimode interference coupler: optimization and fabrication (2004)

The design and fabrication of a 434 multimode interference (MMI) coupler is reported. A photopatternable organic-inorganic sol-gel on silica-on-silicon is adopted for the device fabrication. Optimization of waveguide parameters led to the coupler excess loss below 1 dB and power imbalance below 0.2 dB. An optical 90-deg hybrid based on the coupler is realized and tested. The experimental data are in very good agreement with predicted simulation results, demonstrating the simplicity and exactness of the sol-gel method as an advantageous fabrication route in integrated optics. © 2004 Society of Photo-Optical Instrumentation Engi- neers. (DOI: 10.1117/1.1646180)
Design of integrated passive component for a 1MHz 1kW half-bridge LLC resonant converter (2005)

The LLC resonant converter has some special characteristics to make it an excellent candidate for front-end DC/DC conversion in a distributed power system. Even with advanced topology, to achieve high power density, the passive component design is still the key issue. Passive integration is used to integrate all the passive components within the resonant tank of the LLC resonant converter into one single component - an integrated L-L-C-T. The design approach and loss estimation of the integrated L-L-C-T component for a 1 MHz 1 kW LLC resonant converter is given in this paper. A prototype is constructed and tested under small signal and in-circuit working conditions.
γ-Induced Addition of Dialkyl Phosphites to Olefins and Pyrolysis of the 1: 1 Adducts (1972)

γ-Induced addition of dimethyl, diethyl, and di-n-propyl phosphites to vinyl acetate yielded the 1: 1 and 1: 2 adducts. Similar addition of dimethyl phosphite to allyl acetate gave the 1: 1 adduct. Dimethyl 2-acetoxyethylphosphite and dimethyl 3-acetoxypropylphosphite thus obtained as the 1: 1 adducts were pyrolyzed to yield dimethyl vinylphosphite and dimethyl allylphosphite, respectively. However, diethyl and di-n-propyl 2-acetoxyethylphosphites gave complicated pyrolytic products, ethylene and propylene, respectively, besides acetic acid.
System of optical noncontact microtopography (1993)

In this paper we describe a method of noncontact optical microtopography based on discrete triangulation. We show that a light beam with an oblique incidence on a surface can be used to assess the distance of the latter to a reference plane if the bright spot produced on the surface is imaged onto an array of detectors that tracks its lateral displacement. The light beam is swept over the surface so that large areas can be scanned. The authors have used their system with success for the topographic inspection of several surfaces, e.g., thin copper and silver films, polyethylene rough films and molds, graphite, machined metallic parts, and fabrics.
Production of a Polyunsaturated Isoprenoid Wax Ester during Aerobic Metabolism of Squalene by <i>Marinobacter squalenivorans</i> sp. nov (2003)

This paper describes the production of 5,9,13-trimethyltetradeca-4E,8E,12-trienyl-5,9,13-trimethyltetradeca-4E,8E,12-trienoate during the aerobic degradation of squalene by a Marinobacter strain, 2Asq64, isolated from the marine environment. A pathway involving initial cleavage of the C(10)-C(11) or C(14)-C(15) double bonds of the squalene molecule is proposed to explain the formation of this polyunsaturated isoprenoid wax ester. The isoprenoid wax ester content reached 1.1% of the degraded squalene at the mid-exponential growth phase and then decreased during the stationary phase. The wax ester content increased by approximately threefold in N-limited cultures, in which the ammonium concentration corresponds to conditions often found in marine sediments. This suggests that the bacterial formation of isoprenoid wax esters might be favored in such environments. The bacterial strain is then characterized as a member of a new species, for which we propose the name Marinobacter squalenivorans sp. nov.
CANTINA+ (2011)

Phishing is a plague in cyberspace. Typically, phish detection methods either use human-verified URL blacklists or exploit Web page features via machine learning techniques. However, the former is frail in terms of new phish, and the latter suffers from the scarcity of effective features and the high false positive rate (FP). To alleviate those problems, we propose a layered anti-phishing solution that aims at (1) exploiting the expressiveness of a rich set of features with machine learning to achieve a high true positive rate (TP) on novel phish, and (2) limiting the FP to a low level via filtering algorithms. Specifically, we proposed CANTINA+, the most comprehensive feature-based approach in the literature including eight novel features, which exploits the HTML Document Object Model (DOM), search engines and third party services with machine learning techniques to detect phish. Moreover, we designed two filters to help reduce FP and achieve runtime speedup. The first is a near-duplicate phish detector that uses hashing to catch highly similar phish. The second is a login form filter, which directly classifies Web pages with no identified login form as legitimate. We extensively evaluated CANTINA+ with two methods on a diverse spectrum of corpora with 8118 phish and 4883 legitimate Web pages. In the randomized evaluation, CANTINA+ achieved over 92% TP on unique testing phish and over 99% TP on near-duplicate testing phish, and about 0.4% FP with 10% training phish. In the time-based evaluation, CANTINA+ also achieved over 92% TP on unique testing phish, over 99% TP on near-duplicate testing phish, and about 1.4% FP under 20% training phish with a two-week sliding window. Capable of achieving 0.4% FP and over 92% TP, our CANTINA+ has been demonstrated to be a competitive anti-phishing solution.
Neutral Metallocene Ester Enolate and Non-Metallocene Alkoxy Complexes of Zirconium for Catalytic Ring-Opening Polymerization of Cyclic Esters (2008)

Four neutral zirconocene bis(ester enolate) and non-zirconocene bis(alkoxy) complexes have been employed for ring-opening polymerizations and chain transfer polymerizations of l-lactide (l-LA) and ϵ-caprolactone (ϵ-CL). All C2v-, C2-, and Cs-ligated neutral zirconocene bis(ester enolate) complexes effectively polymerize ϵ-CL at 80 °C with high (>90%) initiator efficiencies. The Cs-ligated complex Ph2C(Cp)(Flu)Zr[OC(OiPr)═CMe2]2 (1) also promotes highly efficient polymerization of l-LA and is at least 100 times more reactive than the C2v- and C2-ligated analogues. The l-LA polymerization by 1 exhibits living characteristics, producing PLA with quantitative isotacticity (no sign of monomer epimerization) and controlled molecular weight. This polymerization follows first-order kinetics with respect to both [l-LA] and [1], consistent with a monometallic, coordination–anionic propagation mechanism. The structurally characterized non-zirconocene bis(alkoxy) complex [(2,6-iPr2C6H4)N(CH2)3N(2,6-iPr2C6H4)]Zr(OiPr)2[O═C(NMe2)CHMe2] (2) has been synthesized in quantitative yield from the reaction of the zirconium bis(amido) precursor with isopropyl isobutyrate. Complex 2 behaves as a single-site catalyst for polymerizations of both ϵ-CL and l-LA, unlike the comparative homoleptic zirconium tetraisopropoxy complex, which shows multisite behavior for the same processes. Both the zirconocene 1 and the non-zirconocene 2 catalyze efficient chain transfer polymerization in the presence of iPrOH as a chain transfer reagent (CTR) for the catalytic production of PLA and PCL, respectively; however, the metallocene system is more robust (in terms of ligand stability and maintaining the polymerization rate) toward an excess of a protic CTR than the present non-metallocene system.
Section 59 in Its Legal Context: Intervening in Family Life (2008)

The repeal of the defence of parental chastisement was a landmark legal development. However, it is only one part in a much larger picture. 'Family law' legislation incorporates a more holistic approach, compared to the criminal law's focus on particular incidents. The issues nevertheless run much deeper than this. The debate about repeal was at its root a battle about the supposed sanctity of family life, but this is a one-sided view of legal policy. Historically the law has credited the State with the role of protector of the vulnerable, in particular children. When the State should intervene remains an acute question.
Security enhancements to TLS for improved national control (2017)

Establishing a secure connection is a must nowadays since a lot of transactions are being done online. For instance, it can vary from buying items from small shops into buying extremely expensive equipment online. Hence, the need for securing the sessions and e-commerce is highly required. Furthermore, any government entity will require its communication to be secured from eavesdropping and Man in The Middle (MITM) attacks. Web Threats are spreading around the world and becoming more aggressive every year. Secure Socket Layer (SSL) and Transport Layer Security (TLS) were established as a standard to encrypt the communication between the client and the server. Everyday new vulnerabilities and loopholes in the internet protocols are being discovered. Hence an enhancement to the TLS protocol is a must. This need rises since most transactions and confidential communication is done through the network. Then information security researchers and developers have to test, develop, verify and enhance the security of the network. Throughout this report a study of the TLS protocol will be highlighted and its relative security. Later, a proposed method to test different TLS protocols will be explained. Future work will include developing a prototype that will be used to test different TLS protocol versions.
Molecular and clinical analysis of <i>ALPL</i> in a cohort of patients with suspicion of Hypophosphatasia (2017)

Hypophosphatasia (HPP) is a rare autosomal dominant or recessive metabolic disorder caused by mutations in the tissue nonspecific alkaline phosphatase gene (ALPL). To date, over 300 different mutations in ALPL have been identified. Disease severity is widely variable with severe forms usually manifesting during perinatal and/or infantile periods while mild forms are sometimes only diagnosed in adulthood or remain undiagnosed. Common clinical features of HPP are defects in bone and tooth mineralization along with the biochemical hallmark of decreased serum alkaline phosphatase activity. The incidence of severe HPP is approximately 1 in 300,000 in Europe and 1 in 100,000 in Canada. We present the clinical and molecular findings of 83 probands and 28 family members, referred for genetic analysis due to a clinical and biochemical suspicion of HPP. Patient referrals included those with isolated low alkaline phosphatase levels and without any additional clinical features, to those with a severe skeletal dysplasia. Thirty-six (43.3%) probands were found to have pathogenic ALPL mutations. Eleven previously unreported mutations were identified, thus adding to the ever increasing list of ALPL mutations. Seven of these eleven were inherited in an autosomal dominant manner while the remaining four were observed in the homozygous state. Thus, this study includes a large number of well-characterized patients with hypophosphatasemia which has permitted us to study the genotype:phenotype correlation. Accurate diagnosis of patients with a clinical suspicion of HPP is crucial as not only is the disease life-threatening but the patients may be offered bone targeted enzymatic replacement therapy. © 2017 Wiley Periodicals, Inc.
Time-resolved coherent and incoherent components of forward light scattering in random media (1990)

Angle- and time-resolved studies are presented for an ultrafast laser pulse propagating through a slab of random media in the intermediate scattering regime, where a coherent (ballistic) component coexists with a incoherent (diffusive) component in the forward-scattered light. The incoherent component can be approximated by diffusion theory when the thickness of the slab is greater than 10 transport mean free paths. The theoretical results from the two-frequency coherence function in the Rytov approximation are in qualitative but not quantitative agreement with the experimental results.
Characterization and correction of eddy-current artifacts in unipolar and bipolar diffusion sequences using magnetic field monitoring (2014)

Diffusion tensor imaging (DTI) of moving organs is gaining increasing attention but robust performance requires sequence modifications and dedicated correction methods to account for system imperfections. In this study, eddy currents in the "unipolar" Stejskal-Tanner and the velocity-compensated "bipolar" spin-echo diffusion sequences were investigated and corrected for using a magnetic field monitoring approach in combination with higher-order image reconstruction. From the field-camera measurements, increased levels of second-order eddy currents were quantified in the unipolar sequence relative to the bipolar diffusion sequence while zeroth and linear orders were found to be similar between both sequences. Second-order image reconstruction based on field-monitoring data resulted in reduced spatial misalignment artifacts and residual displacements of less than 0.43 mm and 0.29 mm (in the unipolar and bipolar sequences, respectively) after second-order eddy-current correction. Results demonstrate the need for second-order correction in unipolar encoding schemes but also show that bipolar sequences benefit from second-order reconstruction to correct for incomplete intrinsic cancellation of eddy-currents.
One-stage clotting versus chromogenic assays for assessing recombinant factor VIII: two faces of a haemostasis coin (2008)

aSezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Italy bServizio di Immonoematologia e Trasfusione, Azienda Ospedaliero-Universitaria di Parma, Australia cDepartment of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, Australia Received 20 July, 2008 Revised 18 September, 2008 Accepted 20 September, 2008 Correspondence to Professor Giuseppe Lippi, MD, Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro, 10, 37134 – Verona, Italy Tel: +39 045 8124516; fax: +39 045 8201889; e-mail: [email protected]
A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells (2008)

Survivin is an attractive target in cancer therapy. Previous studies have demonstrated that survivin dominant-negative mutants T34A and C84A were able to induce apoptosis in cancer cells. Given that they had different mechanisms in inducing apoptosis, our study was undertaken to determine whether a survivin double point mutant (TC34,84AA) could achieve more potent inhibitory effect on the growth of hepatocellular cancer cells. Adenoviruses expressing survivin mutants were constructed and transduced into hepatocellular cancer cells. The inhibitory effect of the survivin mutants on cancer cell growth was measured. Transduction of cancer cells with all three survivin mutants resulted in significant apoptosis. Compared with survivin mutants T34A or C84A alone, the cancer killing effect of survivin TC34,84AA was much stronger. In addition, the survivin mutants were more sensitive than wild type survivin to the degradation in the ubiquitin-proteasome pathway. Our results suggest that adenovirus-delivered dominant-negative survivin TC34,84AA promotes apoptosis-mediated hepatocellular carcinoma suppression, and could potentially be a promising candidate for cancer therapies.
Lab-on-CMOS integration of microfluidics and electrochemical sensors (2013)

This paper introduces a CMOS-microfluidics integration scheme for electrochemical microsystems. A CMOS chip was embedded into a micro-machined silicon carrier. By leveling the CMOS chip and carrier surface to within 100 nm, an expanded obstacle-free surface suitable for photolithography was achieved. Thin film metal planar interconnects were microfabricated to bridge CMOS pads to the perimeter of the carrier, leaving a flat and smooth surface for integrating microfluidic structures. A model device containing SU-8 microfluidic mixers and detection channels crossing over microelectrodes on a CMOS integrated circuit was constructed using the chip-carrier assembly scheme. Functional integrity of microfluidic structures and on-CMOS electrodes was verified by a simultaneous sample dilution and electrochemical detection experiment within multi-channel microfluidics. This lab-on-CMOS integration process is capable of high packing density, is suitable for wafer-level batch production, and opens new opportunities to combine the performance benefits of on-CMOS sensors with lab-on-chip platforms.
BTI Reliability Improvement Strategies in Low Thermal Budget Gate Stacks for 3D Sequential Integration (2018)

Low thermal budget gate stacks will be required for novel integration schemes, such as 3D sequential stacking of CMOS tiers. We study the impact of a reduced thermal budget on BTI reliability, and we demonstrate two strategies to tolerate the inherently large high-k defect densities: i) replacing inversion mode devices with highly doped junction-less transistors, or ii) engineering dipoles at the interface between SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> to suppress the carrier-defect interaction. The latter approach is demonstrated for nMOS PBTI and, for the first time here, also for pMOS NBTI, as even this aging mechanism is controlled by high-k defects in ultra-thin EOT low thermal budget gate stacks.
Anti-hepatitis B virus activity of a mixture of two monoclonal antibodies in an “inhibition in solution” assay (1995)

Two human monoclonal antibodies with anti-hepatitis B activity were investigated separately and as a mixture by means of an “inhibition in solution” assay. With this assay the capacity of anti-HBs antibodies to inhibit the binding of hepatitis B surface antigen (HBsAg) with solid-phase anti-HBs (Ausria II, Abbott Laboratories) was studied. Both HBsAg of different subtypes and purified Dane particles were used. One of the monoclonal antibodies (9H9) was directed against a conformational epitope (anti-“a” like) but induced incomplete inhibition (80% to 90%) of all HBsAg subtypes; the other (4-7B), active against a linear epitope, caused full inhibition of all HBsAg subtypes except one (HBsAg/adw 4 ). In vitro , a mixture of these two monoclonal antibodies was active against HBsAg from liver transplant recipients, including those with suspected variant viruses. (Hepatology 1995; 22:1078-1083.).
Enhanced angular current intensity from Schottky emitters (2010)

Even though the Schottky emitter is a high-brightness source of choice for electron beam systems, its angular current intensity is substantially lower than that of thermionic cathodes, rendering the emitter impractical for applications that require high beam current. In this study, two strategies were attempted to enhance its angular intensity, and their experimental results are reported. The first scheme is to employ a higher extraction field for increasing the brightness. However, the tip shape transformation was found to induce undesirably elevated emission from the facet edges at high fields. The second scheme exploits the fact that the angular intensity is proportional to the square of the electron gun focal length [Fujita, S. & Shimoyama, H. (2005) Theory of cathode trajectory characterization by canonical mapping transformation. J. Electron Microsc. 54, 331–343], which can be increased by scaling-up the emitter tip radius. A high angular current intensity (JΩ∼ 1.5 mA sr−1) was obtained from a scaled-up emitter. Preliminary performance tests were conducted on an electron probe-forming column by substituting the new emitter for the original tungsten filament gun. The beam current up to a few microamperes was achieved with submicron spatial resolution.
Genome-Wide Selective Signature Analysis Revealed Insecticide Resistance Mechanisms in Cydia pomonella (2021)

The codling moth, <i>Cydia pomonella</i> L. (Lepidoptera, Tortricidae), is a serious invasive pest of pome fruits. Currently, <i>C. pomonella</i> management mainly relies on the application of insecticides, which have driven the development of resistance in the insect. Understanding the genetic mechanisms of insecticide resistance is of great significance for developing new pest resistance management techniques and formulating effective resistance management strategies. Using existing genome resequencing data, we performed selective sweep analysis by comparing two resistant strains and one susceptible strain of the insect pest and identified seven genes, among which, two (glycine receptor and glutamate receptor) were under strong insecticide selection, suggesting their functional importance in insecticide resistance. We also found that eight genes including <i>CYP6B2</i>, <i>CYP307a1</i>, <i>5-hydroxytryptamine receptor</i>, <i>cuticle protein</i>, and <i>acetylcholinesterase</i>, are potentially involved in cross-resistance to azinphos-methyl and deltamethrin. Moreover, among several P450s identified as positively selected genes, <i>CYP6B2</i>, <i>CYP4C1</i>, and <i>CYP4d2</i> showed the highest expression level in larva compared to other stages tested, and <i>CYP6B2</i> also showed the highest expression level in midgut, supporting the roles they may play in insecticide metabolism. Our results provide several potential genes that can be studied further to advance understanding of complexity of insecticide resistance mechanisms in <i>C. pomonella</i>.