gebhart/patrepeval huggingface dataset:
Texturing 3D Models of Real World Objects from Multiple Unregistered Photographic Views (1999)

As the efficiency of computer graphic rendering methods is increasing, generating realistic models is now becoming a limiting factor. In this paper we present a new technique to enhance already existing geometry models of real world objects with textures reconstructed from a sparse set of unregistered still photographs. The aim of the proposed technique is the generation of nearly photo‐realistic models of arbitrarily shaped objects with minimal effort. In our approach, we require neither a prior calibration of the camera nor a high precision of the user's interaction. Two main problems have to be addressed of which the first is the recovery of the unknown positions and parameters of the camera. An initial estimate of the orientation is calculated from interactively selected point correspondences. Subsequently, the unknown parameters are accurately calculated by minimising a blend of objective functions in a 3D‐2D projective registration approach. The key point of the proposed method of registration is a novel filtering approach which utilises the spatial information provided by the geometry model. Second, the individual images have to be combined yielding a set of consistent texture maps. We present a robust method to recover the texture from the photographs thereby preserving high spatial frequencies and eliminating artifacts, particularly specular highlights. Parts of the object not seen in any of the photographs are interpolated in the textured model. Results are shown for three complex example objects with different materials and numerous self‐occlusions.
Margaret Michaelis, judía, anarquista y fotógrafa (1998)

53Mn radionuclide (T(1/2) = 3.7 x 10(6) y) is produced through the interaction of cosmic rays. Measurements of concentrations of 53Mn in rocks might help to understand Earth surface processes that occurred in time periods not accessible with other cosmogenic nuclides. Only accelerator mass spectrometry (AMS) can determine such ultratrace levels of 53Mn. The main interference in the detection of 53Mn by AMS is its stable isobar 53Cr, which is roughly approximately 10(12) times more abundant in nature. A prerequisite of any AMS measurement of 53Mn in geological samples is therefore chromium separation by an efficient chemistry. Thus, we have developed a method for the separation of chromium and manganese by using a radiometric simulation. The separation procedure was monitored by 51Cr (T(1/2) = 27.70 d) and 52Mn (T(1/2) = 5.59 d) as the corresponding radiotracers for chromium and manganese, respectively. The separation studies were performed by a liquid-liquid extraction technique using trioctylamine (TOA) diluted in cyclohexane. A high separation factor (approximately 16 000) for Mn and Cr can be obtained at optimal conditions of 0.8 M TOA and 9 M HCl. The developed method has been found equally applicable for real geological samples such as manganese crusts, lava, and sediment samples. Therefore, the method offers an important tool to improve 53Mn measurements by AMS.
Intervention strategies for microbial therapeutics in cancer immunotherapy (2020)

Immunotherapies have drastically improved clinical outcomes in a wide range of malignancies. Nevertheless, patient responses remain highly variable, and reliable biomarkers that predict responses accurately are not yet fully understood. Compelling evidence from preclinical studies and observational data from clinical cohorts have shown that commensal microorganisms that reside in the human gastrointestinal tract, collectively termed the 'microbiome', can actively modify responses to chemotherapeutic agents and immunotherapies by influencing host immunosurveillance. Notably, microbial correlates are largely context specific, and response signatures may vary by patient population, geographic location and type of anticancer treatment. Therefore, the incongruence of beneficial microbiome signatures across studies, along with an emerging understanding of the mechanisms underlying the interactions between the microbiome, metabolome and host immune system, highlight a critical need for additional comprehensive and standardized multi-omics studies. Future research should consider key host factors, such as diet and use of medication, in both preclinical animal models and large-scale, multicenter clinical trials. In addition, there is a strong rationale to evaluate the microbiome as a tumor-extrinsic biomarker of clinical outcomes and to test the therapeutic potential of derived microbial products (e.g. defined microbial consortia), with the eventual goal of improving the efficacy of existing anticancer treatments. This review discusses the importance of the microbiome from the perspective of cancer immunotherapies, and outlines future steps that may contribute to wide-ranging clinical and translational benefits that may improve the health and quality of life of patients with cancer.
Pay as you Browse: Microcomputations as Micropayments in Web-based Services (2011)

Currently, several online businesses deem that advertising revenues alone are not sufficient to generate profits and are therefore set to charge for online content. In this paper, we explore a complement to the current advertisement model; morespecifically, weproposeamicropaymentmodelfornonspecialized commodity web-services based on microcomputations. In our model, a user that wishes to access online content offered by a website does not need to register or pay to access the website; instead, he will accept to run microcomputations on behalf of the website in exchange for access to the content. These microcomputations can, for example, support ongoing computing projects that have clear social benefits (e.g., projects relating to HIV, dengue, cancer, etc.) or can contribute towards commercial computing projects. We argue that this micropayment model is economically and technically viable and that it can be integrated in existing distributed computing frameworks (e.g., the BOINC platform). We implement a preliminary prototype of a system based on our model through which we evaluate its performance and usability. Finally, we analyze the security and privacy of our proposal and we show that it ensures payment for the content while preserving the privacy of users.
The organisation of methanol dehydrogenase and <i>c</i>‐type cytochromes on the respiratory membrane of <i>Methylophilus methylotrophus</i> (1984)

The membrane‐impermeant, protein‐labelling reagent [ 14 C]isethionyl acetimidate has been used to investigate the detailed topography of the membrane‐associated methanol oxidase system in the methylotrophic bacterium Methylophilus methylotrophus . The results show that methanol dehydrogenase and cytochrome c 1 are significantly less exposed on the periplasmic surface of the membrane than either cytochrome C H or an as yet unidentified 12‐kDa protein. The partial crypticity of the methanol dehydrogenase has been confirmed by fingerprinting with V8 protease. The results are discussed in terms of the electron transfer functions of the various redox proteins.
Development of Lithium Dimethyl Phosphate as an Electrolyte Additive for Lithium Ion Batteries (2016)

The novel electrolyte additive lithium dimethyl phosphate (LiDMP) has been synthesized and characterized. Incorporation of LiDMP (0.1% wt) into LiPF6 in ethylene carbonate (EC) / ethyl methyl carbonate (EMC) (3:7 wt) results in improved rate performance and reduced impedance for graphite / LiNi1/3Mn1/3Co1/3O2 cells. Ex-situ surface analysis of the electrodes suggests that incorporation of LiDMP results in a modification of the solid electrolyte interphase (SEI) on the anode. A decrease in the concentration of lithium alkyl carbonates and an increase in the concentration of lithium fluoro phosphates are observed. The change in the anode SEI structure is responsible for the increased rate performance and decreased cell impedance.
Induction of receptive field plasticity in the auditory cortex of the guinea pig during instrumental avoidance conditioning. (1996)

Classical tone conditioning shifts frequency tuning in the auditory cortex to favor processing of the conditioned stimulus (CS) frequency versus other frequencies. This receptive field (RF) plasticity is associative, highly specific, rapidly acquired, and indefinitely retained-all important characteristics of memory. The investigators determined whether RF plasticity also develops during instrumental learning. RFs were obtained before and up to 24 hr after 1 session of successful 1-tone avoidance conditioning in guinea pigs. Long-term RF plasticity developed in all subjects (N = 6). Two-tone discrimination training also produced RF plasticity, like classical conditioning. Because avoidance responses prevent full elicitation of fear by the CS, long-term RF plasticity does not require the continual evocation of fear, suggesting that neural substrates of fear expression are not essential to RF plasticity.
Methyl Alcohol Poisoning (1977)

• Rhesus monkeys were intoxicated with methyl alcohol, using an initial dose of 2 gm/kg and subsequent doses were administered in order to maintain an attenuated and prolonged state of intoxication. Arterial blood samples were drawn for methyl alcohol, formate, Po<sub>2</sub>, Pco<sub>2</sub>, and pH, which were monitored periodically throughout the course of the experiment. With the use of these procedures monkeys developed metabolic acidosis with the accumulation of formic acid in the blood and a corresponding decrease in blood bicarbonate. These animals served as models, which allowed for ocular evaluation for early signs related to methyl alcohol poisoning. A mechanism to explain toxicity is proposed and discussed. (<i>Arch Ophthalmol</i>95:1847-1850, 1977)
Studies in electrohydrodynamics. I. The circulation produced in a drop by an electric field (1966)

Abstract The elongation of a drop of one dielectric fluid in another owing to the imposition of an electric field has previously been studied assuming that the interface is uncharged and the fluids at rest. For a steady field this is unrealistic, because however small the conductivity of either fluid the charge associated with steady currents must accumulate at the interface till the steady state is established. It is shown that equilibrium can only be established in a drop when circulations are set up both in the drop and its surroundings. A relation is found between the ratios of the conductivity, viscosity and dielectric constant for the drop and surrounding fluid which permits the drop to remain spherical when subjected to a uniform field. The streamlines of the circulation for this case are shown and criteria are given for distinguishing between circulations which carry the surface of the drop towards or away from the poles and for predicting whether the drop will become prolate or oblate. Experiments by S. G. Mason and his co-workers are compared with the theoretical predictions and agreement is found in all cases for which the necessary data are given.
Congestion Control in Multicast Transport Protocols (1998)

We discuss congestion control mechanisms in multicast transport protocols and we propose TCP-M - a TCP-friendly Multicast transport protocol. TCP-M uses IP multicast to deliver data packets and acknowledgements to provide reliability. Ack implosion at the source is prevented by fusing acknowledgements at some intermediate routers. TCP-M reacts to network congestion exactly like TCP by having the sender emulate a TCP sender.
Optimization of Procedures for Counting Viruses by Flow Cytometry (2004)

The development of sensitive nucleic acid stains, in combination with flow cytometric techniques, has allowed the identification and enumeration of viruses in aquatic systems. However, the methods used in flow cytometric analyses of viruses have not been consistent to date. A detailed evaluation of a broad range of sample preparations to optimize counts and to promote the consistency of methods used is presented here. The types and concentrations of dyes, fixatives, dilution media, and additives, as well as temperature and length of incubation, dilution factor, and storage conditions were tested. A variety of different viruses, including representatives of phytoplankton viruses, cyanobacteriophages, coliphages, marine bacteriophages, and natural mixed marine virus communities were examined. The conditions that produced optimal counting results were fixation with glutaraldehyde (0.5% final concentration, 15 to 30 min), freezing in liquid nitrogen, and storage at -80 degrees C. Upon thawing, samples should be diluted in Tris-EDTA buffer (pH 8), stained with SYBR Green I (a 5 x 10(-5) dilution of commercial stock), incubated for 10 min in the dark at 80 degrees C, and cooled for 5 min prior to analysis. The results from examinations of storage conditions clearly demonstrated the importance of low storage temperatures (at least -80 degrees C) to prevent strong decreases (occasionally 50 to 80% of the total) in measured total virus abundance with time.
An Instrument for Measuring the Contour of the Cornea (1968)

An instrument designed to measure quantitatively the contour of the human cornea is described. This apparatus can be used to obtain enlarged cross sections of the cornea without harming the eye in any way. An image of a brightly illuminated slit is projected onto the cornea. The intersection of the slit image with the surface of cornea constitutes a section plane through the cornea. The undistorted, enlarged images of selected sections are recorded photographically as corneagrams.
Über Peptidyl‐Prolyl‐<i>cis/trans</i>‐Isomerasen und ihre Effektoren (1994)

Abstract Nimmt ein Protein seine dreidimensionale, gefaltete, native Struktur ein, so sind Konformationsänderungen innerhalb der Polypeptidkette die elementaren Prozesse. Noch vor einigen Jahren galt die Faltung der Proteine in der Zelle als autonomer Vorgang, an dem weder Enzyme noch Hilfsstoffe beteiligt sind. Neuerdings werden immer mehr Faltungshelfer gefunden, zu denen auch Enzyme, die Konformationsänderungen katalysieren, gehören. Die cis / trans ‐Isomerisierung der Peptidbindung, die innerhalb der Kette vor einem Prolinrest lokalisiert ist, wird durch Peptidyl‐Prolyl‐ cis / trans ‐Isomerasen (PPIasen) beschleunigt. Dies sind allgegenwärtige, phylogenetisch hochkonservierte Enzyme, von denen man bisher zwei Familien, die Cyclophiline und die FK506‐bindenden Proteine, kennt. Ihre katalytische Aktivität ist außerordentlich hoch, so daß die Geschwindigkeitskonstanten der von ihnen katalysierten bimolekularen Reaktionen das diffussionskontrollierte Limit für Enzym‐Substrat‐Reaktionen erreichen. Diese Enzyme können die Isomerisierung sowohl von Oligopeptiden als auch von Faltungsintermediaten der Proteine beschleunigen. Welche Struktureinheiten bei Reaktionen in der Zelle als Substrate erkannt und welche Reaktionen dort katalysiert werden, ist noch nicht bekannt. Sicher ist, daß die Isomerasen mit Hitzeschockproteinen der nichtaktivierten Steroidrezeptoren oder auch mit dem gag‐Polyprotein des Aids‐Virus HIV‐1 wechselwirken. Hochwirksame Inhibitoren der PPIasen sind die immunsuppressiven Verbindungen Cyclosporin A und FK506. Überraschenderweise wirken diese Verbindungen zwar in der Signalkette der T‐Zelle, aber nicht durch die Inhibierung des Enzyms; die Inhibitor‐Enzym‐Komplexe selbst sind die Wirkstoffe. Diese haben molekulare Eigenschaften, die die Einzelkomponenten nicht aufweisen, und die nun weitere Zellbestandteile beeinflussen können. Unter diesen Aspekten werden die gegenwärtig diskutierten Modelle zur Unterdrückung der antigen und mitogenstimulierten klonalen Expansion der T‐Zellen vorgestellt.
Downhole injection of OBM cuttings economical in North Sea. [Oil-Based Muds] (1994)

Annular injection offers an economical disposal mechanism for the oily cuttings and associated wastes generated from the use of oil-based muds in drilling operations. This disposal mechanism eliminates overboard cuttings discharges and, hence, removes much concern regarding the environmental impact of these wastes. Continued use of oil-based muds, which perform better than many water-based muds, is therefore feasible. Thus, BP Norway UA has been using the cuttings slurrying and injection process as the prime disposal mechanism for drilling wastes on the Gyda platform in the North Sea since July 1991. The paper describes compliance options, the injection process, injection history, fracture predictions, and results.
Equilibrium between a wobble and ionized base pair formed between fluorouracil and guanine in DNA as studied by proton and fluorine NMR. (1988)

A synthetic oligonucleotide duplex containing the chemotherapeutic and mutagenic agent 5-fluorouracil paired with guanine has been studied in solution by proton and fluorine NMR. The 7-mer duplex containing a central FU.G base pair adopts a normal right-handed configuration. At low pH, the predominant base-paired structure is wobble, whereas at higher pH an ionized structure in Watson-Crick geometry is observed. The two structures are in a pH-dependent equilibrium with one another with an apparent pK of 8.3 at 23 degrees C. This is the first demonstration of an equilibrium between two distinct base pairing schemes and the first demonstration of a negatively charged base pair in DNA.
Solvent Extraction in Biotechnology: Recovery of Primary and Secondary Metabolites (1994)

1 Introduction.- 2 Reaction Engineering Principles.- 3 Extraction Equipment.- 4 Extraction of Metabolites.- References.
Duplicate bug reports considered harmful &#x2026; really? (2008)

In a survey we found that most developers have experienced duplicated bug reports, however, only few considered them as a serious problem. This contradicts popular wisdom that considers bug duplicates as a serious problem for open source projects. In the survey, developers also pointed out that the additional information provided by duplicates helps to resolve bugs quicker. In this paper, we therefore propose to merge bug duplicates, rather than treating them separately. We quantify the amount of information that is added for developers and show that automatic triaging can be improved as well. In addition, we discuss the different reasons why users submit duplicate bug reports in the first place.
Regulation of Olfactory Signalling via cGMP‐Dependent Protein Kinase (1996)

Strong odor stimuli elicit a slow and sustained increase of the cGMP concentration in isolated rat olfactory cilia. Elevated cGMP levels appear to attenuate the primary response to odorant stimulation. Incubating cilia with membrane-permeable cGMP derivates caused a significantly reduced cAMP signal in response to odorant stimulation. This inhibitory effect was mimicked by 8-(4-chlorophenlythio)-cGMP, a selective activator of cGMP-activated protein kinases; in contrast, a selective inhibitor, [8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphorothioate] of cGMP kinases enhanced the reactivity to odorant stimulation. The data suggest that the responsiveness of olfactory sensory cells is governed by a cGMP-dependent protein kinase. Western-blot analysis using subtype-specific antibodies indicated that cytosolic type-I cGMP kinase, but not the membrane-associated type-II cGMP kinase, is expressed in olfactory sensory neurons.
The scattering of fast electrons by atomic nuclei (1929)

Abstract Section 1 .— The hypothesis that the electron has a magnetic moment was, as is well known, first introduced to account for the duplexity phenomena of atomic spectra. More recently, however, Dirac has succeeded in accounting for these same phenomena by the introduction of a modified wave equation, which conforms both to the principle of relativity and to the general transformation theory. Formally, at least, on the new theory also, the electron has a magnetic moment of εh/mc, but when the electron is in an atom we cannot observe this magnetic moment directly; we can only observe the foment of the whole atom, or, of course, the splitting of the spectral lines, which we may say is “caused” by this moment. The question arises, has the free electron "really” got a magnetic moment, a magnetic moment that we can by any conceivable experiment observe? The question is not so simple as it might seem, because a magnetic moment εh/mc can never be observed directly, e.g., with a magnetometer; there is always an uncertainty in the eternal electromagnetic field, due to the uncertainty in the position and velocity of the electron, and this uncertainty is greater than the effect of the electron magnet which we are trying to observe.
The Effect of Hyperglycemia on Experimental Retinal Ischemia (2004)

Preexisting hyperglycemia and the intraocular delivery of glucose markedly attenuate ischemic retinal injury. Clinical Relevance These findings highlight fundamental differences in energy metabolism between brain and retina, have important implications for the pathophysiology of diabetic retinopathy, and may lead to novel therapeutic strategies for ischemic retinopathies.
Relationship between in vitro binding activity and in vivo tumor accumulation of radiolabeled monoclonal antibodies. (1988)

The relationship between in vitro cell binding and in vivo tumor accumulation of radiolabeled antibodies was studied using 125I- and 111In-labeled monoclonal antibodies to human osteosarcoma, and a human osteosarcoma xenograft (KT005) in nude mice. Three monoclonal antibodies--OST6, OST7, and OST15--raised against human osteosarcoma recognize the same antigen molecule. Although the binding of both 125I- and 111In-labeled OST6 to KT005 cells was higher than that of radiolabeled OST7 in vitro, 125I-labeled OST6 showed a faster clearance from the circulation and a lower accumulation in the transplanted tumor than 125I-labeled OST7. In contrast to the radioiodinated antibodies, the in vivo tumor accumulation of 111In-labeled OST6 was higher, although not significantly, than that of 111In-labeled OST7. OST15 showed the lowest binding in vitro, and its in vivo tumor localization was also lower than the others. The discrepancy in tumor uptake between OST6 and OST7 labeled with either 125I or 111In may have been a result of differing blood clearance. These results suggest that binding studies can be used to exclude from in vivo use those antibodies which show very poor binding in vitro, while in vivo serum clearance may be a better test for choosing antibodies with similar binding.
Transition metal complex-catalyzed carbonylation of organic halides in N,N,N',N'-tetraalkylurea solution in the absence of added base (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransition metal complex-catalyzed carbonylation of organic halides in N,N,N',N'-tetraalkylurea solution in the absence of added baseHisao Urata, Hisayuki Maekawa, Shigeharu Takahashi, and Takamasa FuchikamiCite this: J. Org. Chem. 1991, 56, 13, 4320–4322Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/jo00013a050https://doi.org/10.1021/jo00013a050research-articleACS PublicationsRequest reuse permissionsArticle Views503Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts