gebhart/patrepeval huggingface dataset:
Bone marrow‐derived mesenchymal stromal cells accelerate wound healing in the rat (2006)

Bone marrow-derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts, cartilage, bone, muscle, and brain cells. BMSCs also secrete a large number of growth factors and cytokines that are critical to the repair of injured tissues. Because of the extraordinary plasticity and the ability of syngeneic or allogeneic BMSCs to secrete tissue-repair factors, we investigated the therapeutic efficacy of BMSCs for healing of fascial and cutaneous incisional wounds in Sprague-Dawley rats. Systemic administration of syngeneic BMSCs (2 x 10(6)) once daily for 4 days or a single treatment with 5 x 10(6) BMSCs 24 hours after wounding significantly increased the wound bursting strength of fascial and cutaneous wounds on days 7 and 14 postwounding. Wound healing was also significantly improved following injection of BMSCs locally at the wound site. Furthermore, allogeneic BMSCs were as efficient as syngeneic BMSCs in promoting wound healing. Administration of BMSCs labeled with iron oxides/1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate fluorescent dye revealed that systemically administered BMSCs engraft to the wound. The increase in the tensile strength of wounds treated with BMSCs was associated with increased production of collagen in the wound. In addition, BMSC treatment caused more rapid histologic maturation of wounds compared with untreated wounds. These data suggest that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds.
Mechanism of hind limb vasoconstriction due to cyclosporin A in the dog. (1992)

Cyclosporin A (CSA) causes an acute vasoconstriction of hind limb arterial vessels. To determine the mechanism of action of CSA on the peripheral arterial bed, studies were performed on the isolated femoral artery perfused at constant flow in 61 dogs. Changes in femoral perfusion pressure reflected variations in vascular resistance. Pure powder CSA was dissolved in autologous blood and injected at doses of 1, 5, 10, and 20 mg. Infusions of 1 and 5 mg CSA caused nonsignificant mean increases of 4 +/- 2 mm Hg (95% confidence interval [CI], 0-8; p > 0.05) and 10 +/- 4 mm Hg (95% CI, 0-21; p > 0.05) in femoral perfusion pressure, with CSA blood levels in the femoral vein averaging 40 +/- 16 and 126 +/- 50 nmol/l, respectively, at the end of the injections. Infusions of 10 and 20 mg CSA caused significant increases in femoral perfusion pressure averaging of 8 +/- 3 mm Hg (95% CI, 1-14; p < 0.05) and 20 +/- 4 mm Hg (95% CI, 11-29; p < 0.05) in femoral perfusion pressure. CSA blood levels at the end of injections averaged 271 +/- 99 and 431 +/- 146 nmol/l, respectively, in the femoral vein. Blockade of alpha-adrenergic receptors with phentolamine and surgical lumbar sympathectomy decreased significantly the CSA vasoconstrictive effect in peripheral arterial vessels, with increases in perfusion pressure averaging 29 +/- 5 mm Hg before and 14 +/- 3 mm Hg after phentolamine (p < 0.05) and 30 +/- 2 mm Hg before and 8 +/- 2 mm Hg after sympathectomy (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Cooperative spectrum occupancy measurements in the 2.4 GHz ISM band (2010)

This paper presents cooperative spectrum occupancy measurements in the 2.4 GHz ISM band. Spectrum occupancy describes the efficiency of spectrum use in terms of the proportion of time that the bands are occupied. In this paper, spectrum occupancy is measured from two measurement devices with several directional antennas. The spectrum occupancy information obtained from the different antennas and measurement devices is combined using techniques known from the cooperative spectrum sensing research for future cognitive radio systems. We introduce a new metric, the cooperative spectrum occupancy, to characterize the resulting spectrum occupancy that is obtained by combining the occupancy measurements from the antennas with different combining techniques, such as AND, OR, and majority combining rules. Since the transmission power levels at ISM band are low to allow efficient frequency reuse, the resulting spectrum occupancies are heavily dependent on the measurement location. Instead of averaging out the influence of the spatial dimension, the new metric can give more insights into the actual spectrum occupancy in a given area taking into account the spatial dimension.
New developments in calcium ion channel antagonists (1983)

Toward the beginning of this Perspective we posed a number of questions to be answered concerning the Ca2+ channel antagonists. Biochemical, chemical, clinical, pharmacological, and physiological studies collectively support the conclusion that this important group of molecules does function in specific fashion to inhibit Ca2+ channel function. Major questions of mechanisms and sites of action remain, however, to be resolved. The recent radioligand binding assay supports the conclusion, drawn earlier from the chemical and pharmacological heterogeneity of these agents, that there exists multiple sites and mechanisms of action for the Ca2+ channel antagonists. This is a satisfying conclusion, since, although it makes high demands on future experimentation designed to delineate these sites and mechanisms, it indicates the very real possibility for the development of tissue-selective Ca2+ channel antagonists. Elsewhere in this review we have already addressed the question of tissue selectivity as observed for existing compounds. In our opinion, the structural and pharmacological clues available should bring us closer to the goal of second- and third-generation Ca2+ antagonists with defined tissue selectivity.
Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide (2001)

Members of the HCN channel family generate hyperpolarization-activated cation currents (Ih) that are directly regulated by cAMP and contribute to pacemaker activity in heart and brain. The four HCN isoforms show distinct but overlapping patterns of expression in different tissues. Here, we report that HCN1 and HCN2, isoforms coexpressed in neocortex and hippocampus that differ markedly in their biophysical properties, coassemble to generate heteromultimeric channels with novel properties. When expressed in Xenopus oocytes, HCN1 channels activate 5-10-fold more rapidly than HCN2 channels. HCN1 channels also activate at voltages that are 10-20 mV more positive than those required to activate HCN2. In cell-free patches, the steady-state activation curve of HCN1 channels shows a minimal shift in response to cAMP (+4 mV), whereas that of HCN2 channels shows a pronounced shift (+17 mV). Coexpression of HCN1 and HCN2 yields Ih currents that activate with kinetics and a voltage dependence that tend to be intermediate between those of HCN1 and HCN2 homomers, although the coexpressed channels do show a relatively large shift by cAMP (+14 mV). Neither the kinetics, steady-state voltage dependence, nor cAMP dose-response curve for the coexpressed Ih can be reproduced by the linear sum of independent populations of HCN1 and HCN2 homomers. These results are most simply explained by the formation of heteromeric channels with novel properties. The properties of these heteromeric channels closely resemble the properties of I(h) in hippocampal CA1 pyramidal neurons, cells that coexpress HCN1 and HCN2. Finally, differences in Ih channel properties recorded in cell-free patches versus intact oocytes are shown to be due, in part, to modulation of Ih by basal levels of cAMP in intact cells.
On Optimizing Airline Ticket Purchase Timing (2015)

Proper timing of the purchase of airline tickets is difficult even when historical ticket prices and some domain knowledge are available. To address this problem, we introduce an algorithm that optimizes purchase timing on behalf of customers and provides performance estimates of its computed action policy. Given a desired flight route and travel date, the algorithm uses machine-learning methods on recent ticket price quotes from many competing airlines to predict the future expected minimum price of all available flights. The main novelty of our algorithm lies in using a systematic feature-selection technique, which captures time dependencies in the data by using time-delayed features, and reduces the number of features by imposing a class hierarchy among the raw features and pruning the features based on in-situ performance. Our algorithm achieves much closer to the optimal purchase policy than other existing decision theoretic approaches for this domain, and meets or exceeds the performance of existing feature-selection methods from the literature. Applications of our feature-selection process to other domains are also discussed.
On-Road Vehicle Trajectory Collection and Scene-Based Lane Change Analysis: Part I (2016)

This two-part paper aims to study lane change behaviors at the tactical level from an on-road perspective, with a special focus on analyzing the interactions between an ego and surrounding vehicles during the procedure. Part I addresses vehicle trajectory collection, whereas Part II addresses lane change extraction and scene-based behavioral analysis. Different from the general technique of moving object detection and tracking, trajectory collection for tactical driving behavior study is required to have the properties of consistency, completeness, continuity, and accuracy. This paper proposes a system of on-road vehicle trajectory collection, where an instrumented vehicle is developed with multiple horizontal 2-D lidars that have 360° coverage. The software is developed by fitting the laser points of all lidars on a vehicle model using a coupled estimation of features and reliability along frames to achieve accurate state estimations of occluded data and robust data association in multiviewpoint sensing. The performance is investigated extensively, and a large trajectory set is developed through on-road driving at the Fourth Ring Road in Beijing for a total distance of 64 km, with more than 5700 environmental trajectories with a total length of over 19 h. The performance is demonstrated to be of high quality in terms of the required properties. To the authors' knowledge, this is the first system that is able to automatically collect all-around vehicle trajectories during on-road driving and to demonstrate good performance in providing a high-quality database for driving behavior studies from an on-road perspective that addresses vehicle interactions in real-world traffic at the trajectory level.
Sensitivity of gelatin raw materials to cross-linking: The influence of bloom strength, type, and source (2002)

The authors discuss the results of a study that was conducted to determine how sensitivity of cross-linked gelatin materials varied with respect to their bloom strength, type, and source. Twelve gelatin samples were studied: four of type A and eight of type B, all with bloom strengths varying between 100-275. Gelatin rings prepared from these materials were tested separately by the formaldehyde test and the photostability chamber test. Although crosslinking behavior was found to relate to bloom strength, no correlation was found regarding gelatin type or source.
Fast dedicated retransmission scheme for reliable multicast services in OFDMA systems (2006)

In OFDMA systems, multicast data packets are always transmitted with control messages that identify mutli- cast data packets. In case of reliable multicast services, if a multicast data packet is destroyed, the BS must retransmit this packet with a control message. In this case, a lot of downlink resources are wasted, because the control message uses a very robust modulation and coding scheme (MCS) level. Therefore, to solve this problem, we propose a new retransmission scheme for reliable multicast services in OFDMA systems. Using our proposed scheme, we can save a lot of downlink resources because of the reduction of control messages for multicast data packet retransmissions. In this paper, we analyze the downlink cell throughput and the required resources of our proposed scheme for reliable multicast services, and show, via OPNET simulation, that the throughput of our proposed scheme is superior to that of the original scheme in OFDMA systems.
Kinetics of Cytokine Production in the Cornea and Trigeminal Ganglion of C57BL/6 Mice after Corneal HSV-1 Infection (1999)

To investigate the role of cytokines in the pathogenesis of acute herpetic keratitis (HK), we examined the kinetics of cytokine expression in the corneas and the trigeminal ganglia (TG) of C57BL/6Cr (B6) mice after herpes simplex virus type 1 (HSV-1) infection and observed the influence of the targeted disruption of interferon-gamma (IFN-gamma) gene on the clinical course of HK and/or viral clearance. Following corneal infection with HSV-1 Amakata strain, all corneas developed a typical dendritic keratitis. Quantitative analysis using enzyme-linked immunosorbent assay (ELISA) revealed that the expression of interleukin-1alpha (IL-1alpha), IL-5, IL-6, and IFN-gamma in corneas and TGs significantly elevated immediately after infection, peaked between days 2 and 7 postinfection (p.i.), and then diminished. One exception was IFN-gamma, whose expression significantly persisted in the TGs until day 30 p.i. An additional experiment using IFN-gamma-/- (gko) mice revealed that there was no significant difference in the peak level of viral replication in corneas and TGs between gko and B6 mice, although gko mice showed a significant delay of virus clearance in both corneas and TGs (p < 0.005) and higher mortality rate than B6 mice after HSV-1 infection (p < 0.01). These data suggest that the production of proinflammatory cytokines closely correlates with the pathogenesis of HK, and that IFN-gamma plays an important role in enhancing viral clearance from the cornea and TG.
On the origin of species of fibronectin. (1985)

Multiple different subunits of fibronectin are known to occur and their origin has been unclear. Recent results showing that a single fibronectin gene can give rise to several different mRNAs by alternative splicing suggested an explanation for some of this diversity of fibronectin subunits. Because the alternative splicing events occur within the coding region, the mRNAs differ in coding potential. We have prepared recombinant phage containing a rat fibronectin cDNA segment that is present in some fibronectin mRNAs and not in others. This segment was inserted in the beta-galatosidase gene of lambda gt11, and fusion protein produced by lysogens of the recombinant phage was purified and used as immunogen. The resulting antisera recognized some subunits of rat and hamster fibronectins but not others, indicating that inclusion or removal of this segment gives rise to mRNAs that encode different fibronectin subunits. In particular, presence or absence of a 95 amino acid segment appears to account for differences in size among the subunits of plasma fibronectin, whose origin is therefore explained by alternative patterns of RNA splicing.
Were You There? (1998)

Jane W. Peterson, RN, PhD,a nursing professor and anthropologist at Seattle University School of Nursing, Seattle, Washington, has taught community health nursing since 1969. She has researched and published in anthropology and health, with an emphasis on African Americans, and has consulted with the World Health Organization in Indonesia, Myanmar and China. An Episcopalian, she worships at St. Joseph's Catholic Church.
The Design of Networked Exertion Games (2024)

Incorporating physical activity and exertion into pervasive gaming applications can provide health and social benefits. Prior research has resulted in several prototypes of pervasive games that encourage exertion as interaction form; however, no detailed critical account of the various approaches exists. We focus on networked exertion games and detail some of our work while identifying the remaining issues towards providing a coherent framework. We outline common lessons learned and use them as the basis for generalizations for the design of networked exertion games. We propose possible directions of further investigation, hoping to provide guidance for future work to facilitate greater awareness and exposure of exertion games and their benefits.
A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor γ-chain complex (2008)

Platelet adhesion to vascular subendothelium, mediated in part by interactions between collagen and glycoprotein VI (GPVI) complexed with Fc receptor gamma-chain, is crucial for thrombus formation. Antiplatelet therapy benefits patients with various thrombotic and ischemic diseases, but the safety and efficacy of existing treatments are limited. Recent data suggest GPVI as a promising target for a novel antiplatelet therapy, for example, GPVI-specific Abs that deplete GPVI from the surface of platelets. Here, we characterized GPVI-specific auto-Abs (YA-Abs) from the first reported patient with ongoing platelet GPVI deficiency caused by the YA-Abs. To obtain experimentally useful human GPVI-specific mAbs with characteristics similar to YA-Abs, we generated human GPVI-specific mouse mAbs and selected 2 representative mAbs, mF1201 and mF1232, whose binding to GPVI was inhibited by YA-Abs. In vitro, mF1201, but not mF1232, induced human platelet activation and GPVI shedding, and mF1232 inhibited collagen-induced human platelet aggregation. Administration of mF1201 and mF1232 to monkeys caused GPVI immunodepletion with and without both significant thrombocytopenia and GPVI shedding, respectively. When a human/mouse chimeric form of mF1232 (cF1232) was labeled with a fluorescent endocytosis probe and administered to monkeys, fluorescence increased in circulating platelets and surface GPVI was lost. Loss of platelet surface GPVI mediated by cF1232 was successfully reproduced in vitro in the presence of a cAMP-elevating agent. Thus, we have characterized cAMP-dependent endocytosis of GPVI mediated by a human GPVI-specific mAb as what we believe to be a novel antiplatelet therapy.
Pyrroles. XII. The Reaction of Pyrrolealdehydes with Arylacetonitriles<sup>1,2</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrroles. XII. The Reaction of Pyrrolealdehydes with Arylacetonitriles1,2WERNER HERZ and JAY BRASCHCite this: J. Org. Chem. 1958, 23, 5, 711–714Publication Date (Print):May 1, 1958Publication History Published online1 May 2002Published inissue 1 May 1958https://pubs.acs.org/doi/10.1021/jo01099a018https://doi.org/10.1021/jo01099a018research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development and testing of an automated approach to protein docking (2005)

A new version of GRAMM was applied to Targets 14, 18, and 19 in CAPRI Round 5. The predictions were generated without manual intervention. Ten top-ranked matches for each target were submitted. The docking was performed by a rigid-body procedure with a smoothed potential function to accommodate conformational changes. The first stage was a global search on a fine grid with a projection of a smoothed Lennard-Jones potential. The top predictions from the first stage were subjected to the conjugate gradient minimization with the same smoothed potential. The resulting local minima were reranked according to the weighted sum of Lennard-Jones potential, pairwise residue-residue statistical preferences, cluster occupancy, and the degree of the evolutionary conservation of the predicted interface. For Targets 14 and 18, the conformation of the complex was predicted with root-mean-square deviation (RMSD) of the ligand interface atoms 0.68 A and 1.88 A correspondingly. For Target 19, the interface areas on both proteins were correctly predicted. The performance of the procedure was also analyzed on the benchmark of bound-unbound protein complexes. The results show that, on average, conformations of only 3 side-chains need to be optimized during docking of unbound structures before the backbone changes become a limiting factor. The GRAMM-X docking server is available for public use at http://www.bioinformatics.ku.edu.
Characterization of nonlinear properties of soft PZT-piezoceramics (2000)

Abstract We analyze dielectric data obtained on PZT-5A samples which had been electrically deaged in a well defined way. Thus the exponent a of the power law characterizing the ac-field dependence of the effective dielectric coefficient ϵ11* could be determined with high accuracy. The result α′=1.10(1) and α″= 1.07(1) obtained for the real and imaginary part of ϵ11*, respectively, confirms the non-Rayleigh type nonlinearity of soft PZT in the field range of uncorrelated domain wall motion.
Multiple vehicle Bayesian-based domain search with intermittent information sharing (2011)

This paper focuses on the development of Bayesian-based domain search strategies for distributed multiple autonomous vehicles with intermittent information sharing. Multi-sensor fusion based on observations from neighboring vehicles is implemented via binary Bayesian filtering. We will prove that, under appropriate sensor models, the belief of whether objects exist or not will converge to the true state. An uncertainty map based on these probabilities is constructed to guide the vehicles' motion. It will be shown that all objects in the search domain will be detected. Different motion control schemes are numerically tested to illustrate the effectiveness of the proposed strategy.
Dealkylation Reaction of Acetals, Phosphonate, and Phosphate Esters with Chlorotrimethylsilane/Metal Halide Reagent in Acetonitrile, and Its Application to the Synthesis of Phosphonic Acids and Vinyl Phosphates (1981)

Abstract A mild and efficient method has been developed for carbon-oxygen bond cleavage using chlorotrimethylsilane/sodium iodide in acetonitrile. It was applied to synthetic transformation under nonaqueous and neutral conditions, such as acetal deprotection and the synthesis of phosphonic acids from the corresponding dialkyl phosphonates via methanolysis of their silyl esters. Effectiveness of various kinds of metal or ammonium iodides for this type of dealkylation was examined in the acetonitrile solution by 1H NMR. Satisfactory results were also obtained with lithium or potassium iodide in place of sodium iodide. However, copper(I) or quarternary ammonium iodide was ineffective. Chlorotrimethylsilane/lithium bromide in acetonitrile is effective for selective dealkylation of multifunctional phosphonic esters or dialkyl vinyl phosphates.