gebhart/patrepeval huggingface dataset:
An Application of Advanced Alarm Management Tools to an Oil Sand Extraction Plant∗∗This work was supported by an NSERC CRD project with Suncor Energy as an industrial partner. (2015)

For better performance analysis and design improvement of industrial alarm systems, a variety of advanced alarm management tools have been developed recently. These tools are quite comprehensive and handy in various applications, such as the assessment of alarm systems, detection of nuisance alarms, alarm flood analysis, and recommendation of better configurations. To demonstrate the effectiveness of these tools, this paper presents some industrial case studies based on the alarm data collected from an oil sand extraction plant operated by Suncor Energy in northern Alberta, Canada. Application results show the practicality and utility of the advanced alarm management tools for alarm rationalization and routine alarm management.
Face Verification Subject to Varying (Age, Ethnicity, and Gender) Demographics Using Deep Learning (2016)

Human facial appearance is strongly influenced by demographical characteristics such as categorical age, ethnicity, and gender with each category further partitioned into classes-Black, White, Male, Female, Young (18-30), Middle Age (30-50), and Old (50-70)-and groups−mix of classes. Most subjects share a more similar appearance with their own demographic class than with other classes. We evaluate here the accuracy of automatic facial verification for subjects belonging to varying age, ethnicity, and gender categories. Towards that end, we use a convolutional neural network for feature extraction and show that our method yields better performance on individual demographics compared to a commercial face recognition engine. For one-class demographic groups, we corroborate empirical findings that biometric performance on verification is relatively lower for females, young subjects in the 18-30 age group, and blacks. We then expand the scope of our method and evaluate the accuracy of face verification for several multiclass demographic groups. We discuss the results and make suggestions for improving face verification across varying demographics.
Grapevines show seasonal differences in susceptibility to eutypa (1982)

Early-winter pruning results in the highest probability of infection; March pruning, the least.
A third generation many-core processor for secure embedded computing systems (2012)

As compute-intensive products proliferate, there is an ever growing need to provide security features to detect tampering, identify cloned or counterfeit hardware, and deter cybersecurity threats. This paper describes the security features of the third generation 100-core HyperX™ processor which addresses these needs. Programmable security barriers allow the processor to implement a red-black System on Chip solution. The implementation of Physically Unclonable Functions (PUFs), encryption/decryption engines, a secure boot controller, and anti-tamper features enable the engineer to realize a secure embedded computing solution in an ultra-low power, many-core, C programmable processor-memory network.
iParking: An Intelligent Indoor Location-Based Smartphone Parking Service (2012)

Indoor positioning technologies have been widely studied with a number of solutions being proposed, yet substantial applications and services are still fairly primitive. Taking advantage of the emerging concept of the connected car, the popularity of smartphones and mobile Internet, and precise indoor locations, this study presents the development of a novel intelligent parking service called iParking. With the iParking service, multiple parties such as users, parking facilities and service providers are connected through Internet in a distributed architecture. The client software is a light-weight application running on a smartphone, and it works essentially based on a precise indoor positioning solution, which fuses Wireless Local Area Network (WLAN) signals and the measurements of the built-in sensors of the smartphones. The positioning accuracy, availability and reliability of the proposed positioning solution are adequate for facilitating the novel parking service. An iParking prototype has been developed and demonstrated in a real parking environment at a shopping mall. The demonstration showed how the iParking service could improve the parking experience and increase the efficiency of parking facilities. The iParking is a novel service in terms of cost- and energy-efficient solution.
Rapid unbiased bipolar incoherent calculator cube (1983)

Presented in this paper is one of several possible electrooptical engagement array architectures for performing matrix-matrix multiplication using incoherent light. Essential components of this new signal-processing device include two dynamic light valves operating in a reflection mode, a 2-D photodetector array, and a single polarizing beam splitter.
Behavioral synthesis for testability (1992)

this paper, a synthesis for testability approach is resented. In this approach we select test points or gip-flops to be used in Test Point Insertion or Par- tial Scan to enhance circuit testability. The selection is based on circuit behavioral information rather than low level structural description. This allows Test Point Insertion or Partial Scan usa e on circuits described as interconnection of high levefmodules. In this pa er we also pro ose Test Statement Insertion as an aier; native to &st Point Insertion and to Partial Scan. The major advantage of using Test Statement Inser- tion is less pin count and lower test application time overhead than Test Point Inserti0.n and Partial Scan. Our tool has been implemented in a computer pro- gram.
SERUM CONCENTRATIONS AND ALLOTYPES OF IMMUNO-GLOBULINS IN TWO LINES OF MICE GENETICALLY SELECTED FOR "HIGH" OR "LOW" ANTIBODY SYNTHESIS (1970)

Random-bred Swiss mice were selectively bred for 16 generations; selection was based on their agglutinin response to sheep and pigeon erythrocytes to produce a high and a low responder line. The serum levels of individual immunoglobulins differed significantly in these two lines before immunization. The differences in the levels of immunoglobulins were much more marked after immunization with pigeon or sheep erythrocytes. Greater differences between the two lines were noted in IgM and IgG levels than in IgA. Another remarkable finding was the presence of different immunoglobulin phenotypes in the two lines. The high responders were homozygous or heterozygous for heavy-chain linkage groups found separately in the prototype BALB/c and C57BL inbred strains. The low responders were homozygous for a heavy-chain linkage group not present in bred mice in the United States, but observed as a recombinant type among wild mice probably representing a crossover between the heavy-chain linkage groups of the prototype DBA/2 and NH inbred mice.
Techniques for Modeling the Reliability of Fault-Tolerant Systems With the Markov State-Space Approach (1995)

This paper presents a step-by-step tutorial of the methods and the tools that were used for the reliability analysis of fault-tolerant systems. The approach used in this paper is the Markov (or semi-Markov) state-space method. The paper is intended for design engineers with a basic understanding of computer architecture and fault tolerance, but little knowledge of reliability modeling. The representation of architectural features in mathematical models is emphasized. This paper does not present details of the mathematical solution of complex reliability models. Instead, it describes the use of several recently developed computer programs SURE, ASSIST, STEM, and PAWS that automate the generation and the solution of these models.
High-Content Drug Screening with Engineered Musculoskeletal Tissues (2009)

Tissue engineering for in vitro drug-screening applications based on tissue function is an active area of translational research. Compared to targeted high-throughput drug-screening methods that rapidly analyze hundreds of thousands of compounds affecting a single biochemical reaction or gene expression, high-content screening (HCS) with engineered tissues is more complex and based on the cumulative positive and negative effects of a compound on the multiple pathways altering tissue function. It may therefore serve as better predictor of in vivo activity and serve as a bridge between high-throughput drug screening and in vivo animal studies. In the case of the musculoskeletal system, tissue function includes determining improvements in the mechanical properties of bone, tendon, cartilage, and, for skeletal muscle, contractile properties such as rate of contraction/relaxation, force generation, fatigability, and recovery from fatigue. HCS of compound banks with engineered tissues requires miniature musculoskeletal organs as well as automated functional testing. The resulting technologies should be rapid, cost effective, and reduce the number of small animals required for follow-on in vivo studies. Identification of compounds that improve the repair/regeneration of damaged tissues in vivo would have extensive clinical applications for treating musculoskeletal disorders.
Appraising the Need for Altered Sexuality Information (1986)

This article demonstrates the need for an awareness of how patients communicate a readiness for information about altered sexuality. Rehabilitation nurses observed behaviors of spinal cord-injured males communicating their need for this information. The article recommends nursing actions and future research
Oxidation Reduction Potential of Developing Plaque, Periodontal Pockets and Gingival Sulci (1969)

Peer Reviewed
ScanSSH - Scanning the Internet for SSH Servers (2001)

SSH is a widely used application that provides secure remote login. It uses strong cryptography to provide authentication and condentiality. The IETF SecSH working group is developing SSH v2, an improved SSH protocol that xes cryptographic and design aws in the SSH v1 protocol. SSH v2 compatible server software is widespread. Recently discovered security aws make it critically important to nd vulnerable SSH servers and update them. In this paper, we describe a method to determine with good precision how many servers supporting the various protocol versions have been deployed on the net. We describe the design and implementation of ScanSSH, a scanner that probes SSH servers for their software version, and discuss the results of scanning the Internet and our local networks for several months. October 2, 2001 Center for Information Technology Integration University of Michigan 535 West William Street Ann Arbor, MI 48103-4943 . ScanSSH - Scanning the Internet for SSH Servers Niels Provos Peter Honeyman Center for Information Technology Integration University of Michigan 1
Cellular Microvesicle Pathways Can Be Targeted to Transfer Genetic Information between Non-Immune Cells (2009)

Eukaryotic cell communication is based on protein signaling cascades that require direct cell-cell apposition, or receptor engagement by secreted molecules. The transmission of genetic information is thought to be uncommon, apart from recent reports of exosomal RNA transfer in immune and glioblastoma cells. We wished to examine if existing microvesicle pathways could be directly targeted for the horizontal transfer of RNA genomes in less specialized cell types. Using replication-deficient retrovirus vector, studies herein confirm that a range of cells routinely sequester a small population of these RNA genomes in a non-canonical compartment, refractory to antibody neutralization and unaffected by specific pharmacological inhibition of pathways involved in conventional viral trafficking. Our experiments further reveal the cytoplasmic colocalization of vector genomes with tetraspanin proteins as well as the PI-3-kinase sensitive trafficking and subsequent transmission to 2 degrees targets. Collectively, our results indicate a scalable process whereby cells route vector genomes to multivesicular bodies (MVB) for cytoplasmic trafficking and exosomal release. Our findings imply that cells can serve to deliver recombinant payload, targeted for the stable genetic modification of 2 degrees target cells.
Differential signal requirement for upregulation of HLA-class II molecules in human lymphoma B cells. (1993)

HLA-class II molecules can be induced in low-grade non-Hodgkin B lymphoma cells by either membrane IgM cross-linking or phorbolester stimulation. The ability of phorbolesters to substitute for anti-IgM antibodies in the activation of normal and malignant human B cells has been taken as evidence for the involvement of protein kinase C (PKC) in signals transduced through membrane IgM receptors (mIgR). Here we report on freshly isolated lymphoma B cells from different patients; the cells show a distinct regulation of HLA-class II expression. In certain lymphoma cases phorbol-myristate-acetate (PMA) not only fails to up-regulate HLA-class II molecules but also inhibits anti-IgM or interleukin-4 induced class II expression. This negative signal induced by PMA seems to operate specifically in HLA-class II regulation because PMA can induce other anti-IgM mediated events like blast transformation and induction of IL-4 responsiveness at the same time. Therefore these cells support the concept of functional heterogeneity in low-grade non-Hodgkin lymphoma and may represent a differentiation stage where anti-IgM antibodies and phorbolesters influence the regulation of HLA-class II expression in a contrary direction.
Diagnosis system of computer-aided brain MRI using content-based image retrieval (2008)

Retrieving images is a useful tool to help radiologist to check medical image and diagnosis. In this paper, we propose a retrieval system of computer aided brain magnetic resonance imaging diagnosis , which integrated archiving and communication system, feature extraction and storage, feature match, and user interfaces. The system can be access in three ways, (i) using our system including PACS and image retrieval system, (ii)embedded the software into current PACS, and (iii) internet connection to submit an image as a query, and receive in return a set of images from the the web system. The system utilizes sophisticated image processing algorithms, combined with robust database technology and state-of-the-art web-enabled hardware, and packages these capabilities into a tightly-integrated diagnosis environment for the radiologist. This paper outlines the architecture, algorithms, and the test/verification procedures that our system has implemented.
Enabling device-to-device communications in millimeter-wave 5G cellular networks (2015)

Millimeter-wave communication is a promising technology for future 5G cellular networks to provide very high data rate (multi-gigabits-persecond) for mobile devices. Enabling D2D communications over directional mmWave networks is of critical importance to efficiently use the large bandwidth to increase network capacity. In this article, the propagation features of mmWave communication and the associated impacts on 5G cellular networks are discussed. We introduce an mmWave+4G system architecture with TDMA-based MAC structure as a candidate for 5G cellular networks. We propose an effective resource sharing scheme by allowing non-interfering D2D links to operate concurrently. We also discuss neighbor discovery for frequent handoffs in 5G cellular networks.
Axl activates autocrine transforming growth factor‐β signaling in hepatocellular carcinoma (2014)

Our data suggest that Axl/14-3-3ζ signaling is central for TGF-β-mediated HCC progression and a promising target for HCC therapy.
Intracellular Mono-ADP-Ribosylation in Signaling and Disease (2015)

A key process in the regulation of protein activities and thus cellular signaling pathways is the modification of proteins by post-translational mechanisms. Knowledge about the enzymes (writers and erasers) that attach and remove post-translational modifications, the targets that are modified and the functional consequences elicited by specific modifications, is crucial for understanding cell biological processes. Moreover detailed knowledge about these mechanisms and pathways helps to elucidate the molecular causes of various diseases and in defining potential targets for therapeutic approaches. Intracellular adenosine diphosphate (ADP)-ribosylation refers to the nicotinamide adenine dinucleotide (NAD⁺)-dependent modification of proteins with ADP-ribose and is catalyzed by enzymes of the ARTD (ADP-ribosyltransferase diphtheria toxin like, also known as PARP) family as well as some members of the Sirtuin family. Poly-ADP-ribosylation is relatively well understood with inhibitors being used as anti-cancer agents. However, the majority of ARTD enzymes and the ADP-ribosylating Sirtuins are restricted to catalyzing mono-ADP-ribosylation. Although writers, readers and erasers of intracellular mono-ADP-ribosylation have been identified only recently, it is becoming more and more evident that this reversible post-translational modification is capable of modulating key intracellular processes and signaling pathways. These include signal transduction mechanisms, stress pathways associated with the endoplasmic reticulum and stress granules, and chromatin-associated processes such as transcription and DNA repair. We hypothesize that mono-ADP-ribosylation controls, through these different pathways, the development of cancer and infectious diseases.
The Physiology of the Thymus Gland (1954)

Thomas Young, whom we are commemorating, entered on his medical career in 1793 at the age of 20 as a student at my own hospital of St. Bartholomew. He published his first scientific paper on the accommo- dating power of the eye very soon afterwards, and in the next year, 1794, was elected a Fellow of the Royal Society. It may be doubted whether it would now be possible for any medical student, however brilliant, to achieve an F.R.S. in his first year at hospital. The Royal Society, however, took a chance on Thomas Young, and seldom has their choice been more fully justified in the event. I need not enlarge on Young's outstanding achievements in his work on the physiology and physics of the eye. Much of his work has stood the test of time, and his teaching is current at the present day. He was, moreover, a man of extraordinary versatility, so that he became eminent as physiologist, mathematician, physicist, physician to St. George's Hospital, and, un- expectedly, Egyptologist. He was, indeed, the chief interpreter of the Rosetta Stone. He also made observa- tions on the habits of spiders.
Molecular genetics and nomenclature of proteases of <i>Porphyromonas gingivalis</i> (1999)

The strategies used by bacterial pathogens to establish and maintain themselves in the host represent one of the fundamental aspects of microbial pathogenesis. Characterization of these strategies and the underlying molecular machinery offers new opportunities both to our understanding of how organisms cause disease in susceptible individuals and to the development of novel therapeutic measures designed to undermine or interfere with these determinants of successful survival. With respect to the microbial aetiology of the periodontal diseases, a growing body of evidence suggests that the proteolytic enzymes of Porphyromonas gingivalis represent key survival and, by extrapolation, virulence determinants of this periodontal bacterium. This in turn has led to international efforts to characterize these enzymes at the gene and protein level. Approximately 20 protease genes of P. gingivalis with different names and accession numbers have been deposited in the gene databases and a correspondingly heterogeneous nomenclature system is employed for the products of these genes in the literature. However, it is evident, through comparison of these gene sequences and through gene inactivation studies, that the genetic structure of the proteases of this organism, particularly those with specificity for arginyl and lysyl peptide bonds, is less complicated than originally thought. The major extracellular and surface associated arginine specific protease activity is encoded by 2 genes which we recommend be designated rgpA and rgpB (arg-gingipains A & B). Similarly we recommend that the gene encoding the major lysine specific protease activity is designated kgp (lys-gingipain). These three genes, which account for all the extracellular/surface arginine and lysine protease activity in P. gingivalis, belong to a family of sequence-related proteases and haemagglutinins.
Simple and Robust Binary Self-Location Patterns (2011)

A simple method to generate a two-dimensional binary grid pattern, which allows for absolute and accurate self-location in a finite planar region, is proposed. The pattern encodes position information in a local way so that reading a small number of its black or white pixels at any place provides sufficient data from which the location can be decoded both efficiently and robustly.
Multiple pathways for SOS-induced mutagenesis in <i>Escherichia coli</i> : An overexpression of <i>dinB</i> / <i>dinP</i> results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA (1997)

dinP is an Escherichia coli gene recently identified at 5.5 min of the genetic map, whose product shows a similarity in amino acid sequence to the E. coli UmuC protein involved in DNA damage-induced mutagenesis. In this paper we show that the gene is identical to dinB, an SOS gene previously localized near the lac locus at 8 min, the function of which was shown to be required for mutagenesis of nonirradiated lambda phage infecting UV-preirradiated bacterial cells (termed lambdaUTM for lambda untargeted mutagenesis). A newly constructed dinP null mutant exhibited the same defect for lambdaUTM as observed previously with a dinB::Mu mutant, and the defect was complemented by plasmids carrying dinP as the only intact bacterial gene. Furthermore, merely increasing the dinP gene expression, without UV irradiation or any other DNA-damaging treatment, resulted in a strong enhancement of mutagenesis in F'lac plasmids; at most, 800-fold increase in the G6-to-G5 change. The enhanced mutagenesis did not depend on recA, uvrA, or umuDC. Thus, our results establish that E. coli has at least two distinct pathways for SOS-induced mutagenesis: one dependent on umuDC and the other on dinB/P.
Kinetics of Human Immunodeficiency Virus Type 1 (HIV) DNA Integration in Acutely Infected Cells as Determined Using a Novel Assay for Detection of Integrated HIV DNA (2001)

We have developed a novel linker-primer PCR assay for the detection and quantification of integrated human immunodeficiency virus type 1 (HIV) DNA. This assay reproducibly allowed the detection of 10 copies of integrated HIV DNA, in a background of 2 x 10(5) cell equivalents of human chromosomal DNA, without amplifying extrachromosomal HIV DNA. We have used this assay and a near-synchronous one-step T-cell infection model to investigate the kinetics of viral DNA accumulation following HIV infection. We report here that integrated HIV DNA started accumulating 1 h after the first appearance of extrachromosomal viral DNA and accounted for approximately 10% of the total HIV DNA synthesized in the first round of viral replication. These results highlight the efficient nature of integrase-mediated HIV integration in infected T cells.