gebhart/patrepeval huggingface dataset:
A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex. (1993)

Sequence-specific DNA binding has been demonstrated for a synthetic peptide comprising only one of the two "finger"-like domains of the erythroid transcription factor GATA-1 (also termed Eryf-1, NF-E1, or GF-1). Quantitative analysis of gel-retardation assays yields a specific association constant of 1.2 x 10(8) M, compared with values of about 10(9) M for the full-length natural GATA-1 protein. By the use of peptides of various lengths, it was possible to delineate the smallest region necessary for specific binding. A single C-terminal finger of the double-finger motif is necessary but not sufficient for sequence-specific interaction. Basic amino acids located C-terminal to the finger (some more than 20 amino acids away) are also essential for tight binding. In addition to demonstrating that zinc is important for the formation of an active binding complex, we show that other ions, notably Fe2+, can fulfill this role. Our results make it clear that the GATA-1 metal binding motif is quite distinct from that found in the steroid hormone family and that GATA-1 is a member of a separate class of DNA binding proteins.
Supreme Court requires broadcaster to be notified of evidence for police access to e-mails (2014)

During a criminal investigation of two military officers under
the Official Secrets Act 1989 for passing information on the
Cabinet security committee to the broadcaster BSkyB, the police
sought disclosure of evidence from the broadcaster. This included
copies of all e-mails between the officers and the broadcaster.
After hearing the police and the broadcaster, the court issued a
production order. However, a further application, based on secret
information, was made by the police for further evidence; the
broadcaster was not present before the court and objected to the
application. On 12 March 2014, the Supreme Court held that it was
unlawful to make such an order without the broadcaster having full
access to the evidence and an opportunity to comment on it
Integrating surrogate models into subsurface simulation framework allows computation of complex reactive transport scenarios (2017)

We showcase a flexible, extensible yet efficient framework for reactive transport modelling, including the ability to replace “full physics” geochemical simulations with surrogate models for speedup. Surrogates are data-driven models trained on a set of pre-calculated simulations by means of machine-learning methods. We offer also an input-output-error visualization component for interactive assessment and tuning of their accuracy. Our framework, based on open source or freely available software, makes possible complex reactive transport simulations and ease further research on optimized algorithms to tackle many geoscientific problems.
Evaluation of the Second Generation of a Bioresorbable Everolimus Drug-Eluting Vascular Scaffold for Treatment of De Novo Coronary Artery Stenosis (2010)

URL: http://clinicaltrials.gov. Unique identifier: NCT00856856.
Effects of wing leading-edge radius and Reynolds number on longitudinal aerodynamic characteristics of highly swept wing-body configurations at subsonic speeds (1976)

An investigation was conducted in the Langley low turbulence pressure tunnel to determine the effects of wing leading edge radius and Reynolds number on the longitudinal aerodynamic characteristics of a series of highly swept wing-body configurations. The tests were conducted at Mach numbers below 0.30, angles of attack up to 16 deg, and Reynolds numbers per meter from 6.57 million to 43.27 million. The wings under study in this investigation had leading edge sweep angles of 61.7 deg, 64.61 deg, and 67.01 deg in combination with trailing edge sweep angles of 0 deg and 40.6 deg. The leading edge radii of each wing planform could be varied from sharp to nearly round.
Single and Multicomponent Sorption of CO<sub>2</sub>, CH<sub>4</sub>and N<sub>2</sub>in a Microporous Metal-Organic Framework (2008)

Abstract Single and multicomponent fixed-bed adsorption of CO2, N2, and CH4 on crystals of MOF-508b has been studied in this work. Adsorption equilibrium was measured at temperatures ranging from 303 to 343 K and partial pressures up to 4.5 bar. MOF-508b is very selective for CO2 and the loadings of CH4 and N2 are practically temperature independent. The Langmuir isotherm model provides a good representation of the equilibrium data. A dynamic model based on the LDF approximation for the mass transfer has been used to describe with good accuracy the adsorption kinetics of single, binary and ternary breakthrough curves. It was found that the intra-crystalline diffusivity for CO2 is one order of magnitude faster than for CH4 and N2.
Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics (2020)

Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by autoantibodies targeting neuromuscular junction proteins. In the majority of patients (~85%) antibodies against the muscle acetylcholine receptor (AChR) are detected, while in 6% antibodies against the muscle-specific kinase (MuSK) are detected. In ~10% of MG patients no autoantibodies can be found with the classical diagnostics for AChR and MuSK antibodies (seronegative MG, SN-MG), making the improvement of methods for the detection of known autoantibodies or the discovery of novel antigenic targets imperative. Over the past years, using cell-based assays or improved highly sensitive immunoprecipitation assays, it has been possible to detect autoantibodies in previously SN-MG patients, including the identification of the low-density lipoprotein receptor-related protein 4 (LRP4) as a third MG autoantigen, as well as AChR and MuSK antibodies undetectable by conventional methods. Furthermore, antibodies against other extracellular or intracellular targets, such as titin, the ryanodine receptor, agrin, collagen Q, K<sub>v</sub>1.4 potassium channels and cortactin have been found in some MG patients, which can be useful biomarkers. In addition to the improvement of diagnosis, the identification of the patients' autoantibody specificity is important for their stratification into respective subgroups, which can differ in terms of clinical manifestations, prognosis and most importantly their response to therapies. The knowledge of the autoantibody profile of MG patients would allow for a therapeutic strategy tailored to their MG subgroup. This is becoming especially relevant as there is increasing progress toward the development of antigen-specific therapies, targeting only the specific autoantibodies or immune cells involved in the autoimmune response, such as antigen-specific immunoadsorption, which have shown promising results. We will herein review the advances made by us and others toward development of more sensitive detection methods and the identification of new antibody targets in MG, and discuss their significance in MG diagnosis and therapy. Overall, the development of novel autoantibody assays is aiding in the more accurate diagnosis and classification of MG patients, supporting the development of advanced therapeutics and ultimately the improvement of disease management and patient quality of life.
Oil Property Evaluation (1984)

This text is useful to evaluate an oil property. It includes measures of investment worth, reserve analysis, production forecasting, costs, determining working and net revenue interest, severance and ad valorem taxes, a short discussion on the evaluation report. Contents include: Basic concepts; Time value of money; Investment decision analysis; Reserve estimation; Decline curves; Oil and gas prices; Oilfield deals; Costs, Severance and ad valorem taxes; Windfall profit tax; Federal income taxation of oil and gas transactions; The report; Appendices.
STUDIES ON HEMOGLOBIN (1922)

Journal Article STUDIES ON HEMOGLOBIN: I. The Advantage of Alkaline Solutions for Colorimetric Determination of Hemoglobin Get access HSIEN WU HSIEN WU Laboratory of Physiological Chemistry, Peking Union Medical CollegePeking Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 2, Issue 1, October 1922, Pages 173–180, https://doi.org/10.1093/oxfordjournals.jbchem.a125832 Published: 01 October 1922 Article history Published: 01 October 1922 Received: 10 October 1922
Interactive quality-driven feedback for biometric systems (2010)

The application of biometric technology has so far been top-down, driven by governments and law enforcement agencies. The low demand of this technology from the public, despite its many advantages compared to the traditional means of authentication is probably due to the lack of human factor considerations in the design process. In this work, we propose a guideline to design an interactive quality-driven feedback mechanism. The mechanism aims to improve the quality of biométrie samples during the acquisition process by putting in place objective assessment of the quality and feeding this information back to the user instantaneously, thus eliminating subjective quality judgement by the user. We illustrate the feasibility of the design methodology using face recognition as a case study. Preliminary results show that the methodology can potentially increase efficiency, effectiveness and accessibility of a biométrie system.
Simultaneous Discrimination between 15 Fish Pathogens by Using 16S Ribosomal DNA PCR and DNA Microarrays (2004)

We developed a DNA microarray suitable for simultaneous detection and discrimination between multiple bacterial species based on 16S ribosomal DNA (rDNA) polymorphisms using glass slides. Microarray probes (22- to 31-mer oligonucleotides) were spotted onto Teflon-masked, epoxy-silane-derivatized glass slides using a robotic arrayer. PCR products (ca. 199 bp) were generated using biotinylated, universal primer sequences, and these products were hybridized overnight (55 degrees C) to the microarray. Targets that annealed to microarray probes were detected using a combination of Tyramide Signal Amplification and Alexa Fluor 546. This methodology permitted 100% specificity for detection of 18 microbes, 15 of which were fish pathogens. With universal 16S rDNA PCR (limited to 28 cycles), detection sensitivity for purified control DNA was equivalent to <150 genomes (675 fg), and this sensitivity was not adversely impacted either by the presence of competing bacterial DNA (1.1 x 10(6) genomes; 5 ng) or by the addition of up to 500 ng of fish DNA. Consequently, coupling 16S rDNA PCR with a microarray detector appears suitable for diagnostic detection and surveillance for commercially important fish pathogens.
Time-Bounded Essential Localization for Wireless Sensor Networks (2010)

In many practical applications of wireless sensor networks, it is crucial to accomplish the localization of sensors within a given time bound. We find that the traditional definition of relative localization is inappropriate for evaluating its actual overhead. To address this problem, we define a novel problem called essential localization, and present the first rigorous study on the essential localizability of a wireless sensor network within a given time bound. We propose an efficient distributed algorithm for time-bounded essential localization over a sensor network, and evaluate the performance of our algorithm with extensive simulations.
Electrostriction of a Polyurethane Elastomer-Based Polyester (2006)

This paper is dealing with the electromechanical properties of a synthesized polyurethane elastomer film-based polyester. On the basis of the electrostatic-field induced strain, dielectric, and stress-strain measurements carried out under ambient conditions, the electromechanical parameters such as thickness strain, apparent electrostrictive coefficient, effective pressure, mechanical energy density, and Maxwell-effect contribution, were determined. Thickness strain versus the static electric field showed a quadratic dependence up to about 6.3 MV/m, which is consistent with an electrostrictive response. The maximum induced strain of 7% obtained at 16 MV/m is higher than those reported in the literature on unprestrained polyurethane film with noncompliant electrodes. Remarkable apparent electrostrictive coefficient <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$(sim 7.75 10^-16 hboxm^2/hboxV^2)$</tex> and response time (600 ms) were found. Under the actual experimental conditions (rigid electrodes and maximum electrostatic field of 16 MV/m), the effective compressive pressure (0.9 MPa) and mechanical energy density (0.032 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$hboxJ/cm^3$</tex> ) values are quite noticeable. A small Maxwell-effect contribution of only 0.32% was found. The electromechanical parameters of this polyurethane elastomer indicate that this material is potentially useful for practical actuators and sensors.
Chickens in hot weather: Effects of high air temperatures and methods of cooling poultry houses under study (1949)

The experiments with evaporative coolers were conducted by Professor V. S. Asmundson of Poultry Husbandry, Davis, and J. R. Taver- netti, Associate Agricultural Engineer in the Experiment Station, Davis.
Metabolomic study for essential hypertension patients based on dried blood spot mass spectrometry approach (2018)

Hypertension is an increasingly serious public-health challenge worldwide. The traditional blood pressure measurement method could easily and reliably detect blood pressure. However, the delayed symptom onset may influence the screening of essential hypertension (EH). In addition, EH is significantly associated to cardiovascular disease, stroke and kidney disease. Hence, it is urgent to define associated biomarkers with early diagnosis potential for EH. A dried blood spot method integrated with direct infusion mass spectrometry (MS) metabolomic analysis was applied for the detection of metabolites toward 87 EH patients and 91 healthy controls (HC). Multiple algorithms were run on training set (62 EH and 64 HC) for selecting differential metabolites as potential biomarkers. A test set (25 EH and 27 HC) was used to verify and evaluate selected potential biomarkers. A novel blood biomarker model based on Gly, Orn, C10, Orn/Cit, Phe/Tyr, and C5-OH/C8 exhibited potential to differentiate EH patients from HC individuals, with a sensitivity of 0.8400 and a specificity of 0.8889 in test set. The metabolomic analysis of EH is beneficial to the definition of disease-associated biomarkers and the development of new diagnostic approaches. © 2018 IUBMB Life, 70(8):777-785, 2018.
Surgical planning for liver resection (1996)

Surgical resection is the cornerstone of curative therapy for primary and metastatic liver tumors. For best results, the surgeon must know the location of all hepatic tumor nodules relative to the major vessels that define the liver's surgical anatomy. Computed tomography is very sensitive for detecting liver tumors, but its planar slices do not fully address the three-dimensional nature of this surgical problem. We have developed a technique using volume rendering of computed tomography data that provides a preoperative 3D map of the liver showing tumor location relative to key blood vessels. This technique also has important implications for emerging, minimally invasive therapies.
Preparation and characterization of nafion-based nanocomposite membranes for fuel cell applications (2010)

A thesis submitted to the Faculty of Science and Agriculture University of Zululand
In fulfilment of the requirements for the Degree of Doctor of Philosophy, 2010.
Probiotics in animal nutrition: A review (1990)

The normal microflora colonizing the digestive tract in livestock species at five to six days after birth can be summarized as following: 400 to 500 different bacterial strains for a total count of 10(14) bacteriae. The role of the gut flora is multifarious: fermentation of feed compounds, induction of anatomical and physiological changes in the intestinal cell wall structure, increase in animal resistance against enteropathogenic bacteriae, etc. In the present review, the numerous hypotheses for explaining the beneficial effects of probiotics on zootechnical performances and also the healthy aspects for men and animals are summarized, and the possible mechanisms of bacterial attachment are enumerated. The different assumptions on mode of action and fixation mechanisms of probiotics in the gut are critically discussed, and the required characteristics of the ideal probiotic are listed. Finally, some zootechnical results obtained with lactic acid bacteria are shown for calves, piglets and broilers.
HTML 4 Unleashed (1997)

From the Publisher:
A comprehensive guide and reference to the foundation language of the World Wide Web, HTML 4 Unleashed provides an exhaustive resource devoted to the language of Web development. The Web's explosive growth continues to provide us with an expanding market of Web authors ranging from casual home hobbyists to the professional Web developer. HTML 4 Unleashed will provide these readers the information they need to grow with an ever-changing technology.
Covers all the latest proprietary extensions, including Microsoft's Active HTML and Netscape's JavaScript Stylesheets
Includes information on integrating HTML with other technologies like Java and ActiveX
Details new HTML technologies like the experimental Cougar specification, Cascading Style Sheets and Extensible Markup Language (XML)
Two Dynamically Distinct Inhibitory Networks in Layer 4 of the Neocortex (2003)

Normal operations of the neocortex depend critically on several types of inhibitory interneurons, but the specific function of each type is unknown. One possibility is that interneurons are differentially engaged by patterns of activity that vary in frequency and timing. To explore this, we studied the strength and short-term dynamics of chemical synapses interconnecting local excitatory neurons (regular-spiking, or RS, cells) with two types of inhibitory interneurons: fast-spiking (FS) cells, and low-threshold spiking (LTS) cells of layer 4 in the rat barrel cortex. We also tested two other pathways onto the interneurons: thalamocortical connections and recurrent collaterals from corticothalamic projection neurons of layer 6. The excitatory and inhibitory synapses interconnecting RS cells and FS cells were highly reliable in response to single stimuli and displayed strong short-term depression. In contrast, excitatory and inhibitory synapses interconnecting the RS and LTS cells were less reliable when initially activated. Excitatory synapses from RS cells onto LTS cells showed dramatic short-term facilitation, whereas inhibitory synapses made by LTS cells onto RS cells facilitated modestly or slightly depressed. Thalamocortical inputs strongly excited both RS and FS cells but rarely and only weakly contacted LTS cells. Both types of interneurons were strongly excited by facilitating synapses from axon collaterals of corticothalamic neurons. We conclude that there are two parallel but dynamically distinct systems of synaptic inhibition in layer 4 of neocortex, each defined by its intrinsic spiking properties, the short-term plasticity of its chemical synapses, and (as shown previously) an exclusive set of electrical synapses. Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity.
[Asynchronous sequential stimulation. A new signal treatment for cochlear implants]. (1997)

Cochlear implants use a fixed or FO dependent stimulation rate, whatever the sound analysed (vowel or consonant) and its analysis procedure (fixed filters or FFT). We present a procedure which varies as a function of the nature of the input signal. This method is based on FFT analysis using a variable with analysis window. Short windows are applied on the transient part of the signal, providing poor frequency resolution but good time resolution; they accurately permit to follow the speech signal in time during its fast temporal variations. Large windows are applied on the stationary parts of the signal, providing better frequency resolution, but poor time resolution. Transient parts of the speech order this window switching; they are detected using the statistical properties of the FFT; moreover the narrow windowing is coupled with an increase of the stimulation frequency. This strategy has been implemented using the Digisonic cochlear implant software, and clinically assessed on 6 regular cochlear implant users, owing to a consonant-vowel-consonant test. This Asynchronous-Interleaved-Stimulation (AIS) strategy provides the patients with better discrimination than fixed window FFT analysis. The coding protocol are described and results presented.
A New Method for Assessing the Gloss of Human Skin (1996)

A new method for an objective assessment of the gloss of human skin is presented. The reflectometric measuring set-up complies with DIN 67530. The principle of this new method is based on a contactless determination of the skin's reflection of light from a tungsten filament lamp, recorded at an angle of 60 degrees by a silicon photocell. In a comparative study with 30 test persons it was discovered that the forehead, with 2.70 standardised reflectometer units (RU; SD +/- 0.59 RU), displayed a significantly higher gloss than the lower arm (1.99 RU, SD 0.28 RU, p < 0.0001). In an investigation into the influence of four different cream bases on the skin gloss it could be determined that the value depends on the percentage of grease, the water concentration and the consistency of the respective base. The method presented permits a fast, contactless, randomly repeatable objective assessment of skin gloss. Since the acceptance of cosmetics and pharmaceutical products depends not least on their skin gloss effect, this method can provide valuable information when estimating the success of old and new products.
Magnetic Ordering in Relation to the Room-Temperature Magnetoelectric Effect of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>Sr</mml:mi><mml:mn>3</mml:mn></mml:msub><mml:msub><mml:mi>Co</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi>Fe</mml:mi><mml:mn>24</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mn>41</mml:mn></mml:msub></mml:math> (2011)

The origin of a room-temperature magnetoelectric (ME) effect has been examined by means of neutron powder diffraction measurements for a Z-type hexaferrite Sr(3)Co(2)Fe(24)O(41). The temperature and magnetic-field dependence of the electric polarization P and several magnetic Bragg reflections show that a commensurate magnetic order with a (0,0,1) propagation vector has an intimate connection with the ME effect. The room-temperature ME effect can be understood in terms of the appearance of P which is induced by a transverse conical spin structure through the inverse Dzyaloshinskii-Moriya mechanism in analogy with Y-type hexaferrites.
FPGA-BASED CHIRP GENERATOR FOR HIGH RESOLUTION UAV SAR (2009)

This paper discusses the design and development of a FPGA-based chirp generator for high resolution Unmanned Aerial Vehicle (UAV) Synthetic Aperture Radar. The desired bandwidth of the chirp signal is 100 MHz (combination of I and Q channels) with a chirp rate of 5 MHz/s. Two algorithms based on the Memory-based architecture and the Direct Digital Synthesizer (DDS) architecture are presented. The measurement results indicate that the DDS chirp generator is a preferred choice for high-resolution SAR application.