gebhart/patrepeval huggingface dataset:
Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation (2000)

c-src deletion in mice leads to osteopetrosis as a result of reduced bone resorption due to an alteration of the osteoclast. We report that deletion/reduction of Src expression enhances osteoblast differentiation and bone formation, contributing to the increase in bone mass. Bone histomorphometry showed that bone formation was increased in Src null compared with wild-type mice. In vitro, alkaline phosphatase (ALP) activity and nodule mineralization were increased in primary calvarial cells and in SV40-immortalized osteoblasts from Src(-/-) relative to Src(+/+) mice. Src-antisense oligodeoxynucleotides (AS-src) reduced Src levels by approximately 60% and caused a similar increase in ALP activity and nodule mineralization in primary osteoblasts in vitro. Reduction in cell proliferation was observed in primary and immortalized Src(-/-) osteoblasts and in normal osteoblasts incubated with the AS-src. Semiquantitative reverse transcriptase-PCR revealed upregulation of ALP, Osf2/Cbfa1 transcription factor, PTH/PTHrP receptor, osteocalcin, and pro-alpha 2(I) collagen in Src-deficient osteoblasts. The expression of the bone matrix protein osteopontin remained unchanged. Based on these results, we conclude that the reduction of Src expression not only inhibits bone resorption, but also stimulates osteoblast differentiation and bone formation, suggesting that the osteogenic cells may contribute to the development of the osteopetrotic phenotype in Src-deficient mice.
Theoretical and Experimental Studies on Pulse Tube Refrigerator (2009)

LWI may be suitable for patients with limited to normal frontal plane ankle mobility. Patients with greater frontal plane ankle mobility benefit most from frontal plane ankle bridging with AFO. Studies with larger samples are necessary.
Changes in Jasmonates of Mangoes during Development and Storage after Varying Harvest Times (2004)

Jasmonic acid (JA) and methyl jasmonate (MeJA) were quantified in the skin, pulp, and seeds of `Nam Dok Mai' and `Nang Klangwan' mangoes ( Mangifera indica L.). JA showed similar changes during development in both cultivars of fruit. JA concentrations were high in the early growth stages of skin and pulp development, decreased with days after full bloom (DAFB), and then increased again during ripening. JA concentrations in the skin were higher than those in the pulp. 1-aminocyclopropane-1-carboxylic acid (ACC) concentrations in the skin and pulp of both cultivars increased toward harvest. Differing with JA, ACC concentrations in the pulp were high compared with the skin. This fact suggests that although JA and ACC are associated with the ripening of mangoes, they may play different roles. JA concentrations in the seeds of both cultivars decreased toward harvest, possibly suggesting a lack of dormancy in mango seeds. Changes in jasmonates during storage were also examined. JA content in the skin and pulp increased in stored fruit. In addition, the increase in JA content was largest in fruit that lost the most fresh weight. This suggests that JA accumulation that occurs during fruit senescence is associated with moisture loss.
Regulation of anti–cyclic citrullinated peptide antibodies in rheumatoid arthritis: Contrasting effects of HLA–DR3 and the shared epitope alleles (2005)

The HLA-DRB1 SE is strongly associated with the production of anti-CCP antibodies, but not RF. In contrast, HLA-DR3 alleles are associated with anti-CCP- disease and with lower levels of anti-CCP antibodies, even when controlling for the SE. These data emphasize the complexity of the genetic effects of the major histocompatibility complex on the RA phenotype.
The Process of Plume-Lithosphere Interactionsin the Ocean Basins-the Caseof Grande Comore (1998)

Grande comore island is formed by two contemporaneously active volcanoes, karthala and la grille. previous work has shown that la grille lavas are alkalic low-degree melts of a metasomatized lithospheric mantle source containing amphibole. this study presents major, trace element and sr–nd–pb isotope analyses of a detailed sample suite from karthala. the lavas are alkali basalts displaying trace element and isotopic variations that indicate mixing between the deep mantle plume source and the lithospheric mantle source of la grille. this study delineates how the process of plume–lithosphere interaction occurs in grande comore, characterizes the composition of the metasomatized lithospheric mantle, and identifies its origin. lithosphere-derived la grille lavas show similar trace element patterns to plume-related karthala lavas, but lower trace element contents for comparable degrees of partial melting. addition of a few percent of plume melt to anhydrous depleted lithospheric mantle generates a mantle composition that can serve as the source of la grille lavas. this plume-related metasomatism occurs pervasively at the base of the lithospheric mantle, lowers its solidus temperature, and causes it to be a major contaminant of plume melts. karthala lavas are shown to be mixtures of plume melts with high-degree melts of the lithospheric mantle. to the extent that this process is valid in other locations, it implies that isotopic variations of other oceanic islands may reflect contamination of nearly uniform plume melts with lithospheric melts.
A Novel Hydrogen Sulfide Prodrug, <scp>SG</scp>1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients (2015)

Recent studies demonstrate robust molecular cross talk and signaling between hydrogen sulfide (H2 S) and nitric oxide (NO). Heart failure (HF) patients are deficient in both H2 S and NO, two molecules that are critical for cardiovascular homeostasis. A phase I clinical trial of a novel H2 S prodrug (SG1002) was designed to assess safety and changes in H2 S and NO bioavailability in healthy and HF subjects. Healthy subjects (n = 7) and heart failure patients (n = 8) received oral SG1002 treatment in escalating dosages of 200, 400, and 800 mg twice daily for 7 days for each dose. Safety and tolerability were assessed by physical examination, vital signs, and ECG analysis. Plasma samples were collected during a 24-h period each week for H2 S and NO analysis. BNP and glutathione levels were analyzed as markers of cardiac health and redox status. Administration of SG1002 resulted in increased H2 S levels in healthy subjects. We also observed increased H2 S levels in HF subjects following 400 mg SG1002. Nitrite, a metabolite of NO, was increased in both healthy and HF patients receiving 400 mg and 800 mg SG1002. HF subjects treated with SG1002 displayed stable drug levels over the course of the trial. SG1002 was safe and well tolerated at all doses in both healthy and HF subjects. These data suggest that SG1002 increases blood H2 S levels and circulating NO bioavailability. The finding that SG1002 attenuates increases in BNP in HF patients suggests that this novel agent warrants further study in a larger clinical study.
Generic personality and emotion simulation for conversational agents: Research Articles (2004)

This paper describes a generic model for personality, mood and emotion simulation for conversational virtual humans. We present a generic model for updating the parameters related to emotional behaviour, as well as a linear implementation of the generic update mechanisms. We explore how existing theories for appraisal can be integrated into the framework. Then we describe a prototype system that uses the described models in combination with a dialogue system and a talking head with synchronized speech and facial expressions. Copyright © 2004 John Wiley & Sons, Ltd.
Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration (2005)

In this study, a high dietary intake of beta carotene, vitamins C and E, and zinc was associated with a substantially reduced risk of AMD in elderly persons.
Early trade unionism on the gold mines in South Africa and Australia : a comparison (1990)

South African and Australian societies share many common elements and experiences including a British settler heritage, gold, similar British trade union impetus, and a colonial period which was roughly contemporaneous. Despite this, the mining trade which evolved in the first few decades after the discovery of gold in each country, was markedly different: South African trade remained weak in its organization and adhered to a thoroughly exclusive and old unionist policy; in Australia on the other hand, where the gold-digger was not faced with large-scale organized capital, gold-mining trade ironically attained formidable membership and moved in the direction of new unionism by embracing the idea of a broader worker alliance. The reasons for this include various specific local material conditions in the respective countries, such as the geological nature of the gold reefs, the methods of gold extraction, the structure of the labour force, the origin of capital and its control, as well as the political dispensation. These factors shaped a trade which was unique to each country and fully indigenized.
Software performance engineering: a case study including performance comparison with design alternatives (1993)

Software performance engineering (SPE) provides an approach to constructing systems to meet performance objectives. The authors illustrate the application of SPE to an example with some real-time properties and demonstrate how to compare performance characteristics of design alternatives. They show how SPE can be integrated with design methods and demonstrate that performance requirements can be achieved without sacrificing other desirable design qualities such as understandability, maintainability, and reusability.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ringöffnungen der Azole, VI. Die Thermolyse 2.5‐disubstituierter Tetrazole zu Nitriliminen (1961)

Abstract 2.5‐Diphenyl‐ und 2‐Phenyl‐5‐methyl‐tetrazol gehen bei 160° , 2‐Methyl‐5‐phenyl‐tetrazol bei 220 ° unter Stickstoffabgabe in die disubstituierten Nitrilimine über. Als labile Zwischenstufen vermögen diese in situ primäre und sekundäre Amine, Thiophenole, Phenole und Carbonsäuren zu addieren.
Dielectric Planarization using Mn2O3 Slurry (1997)

We have developed an Mn2O3 slurry for dielectric planarization for the first time. Our Mn2O3 slurry has 4 times the removal rate of conventional slurry. The removal rate for this slurry remains constant for between l wt% and 10 wt% solid concentration. Pad-conditioning-free polish was successfully realized. We demonstrated that this slurry is reproducible.
Low-loss silica core-borosilicate clad fiber optical waveguide (1973)

A low-loss fiber optical waveguide has been constructed having a pure fused silica core of 40-μm diameter and a chemical-vapor-deposited cladding layer of borosilicate glass 15–20 μm thick. This core-clad structure has an outer jacket of fused silica which serves to strengthen and protect the waveguide. Fabrication procedures and evaluation techniques are described. One fiber has been found to have a minimum optical attenuation of 13 dB/km at a wavelength of 0.7 μm. In the range 0.8–1.1 μm, where optical communications appear most promising, the attenuation varies between 18 and 22 dB/km with the exception of the OH absorption peak at 0.95 μm.
The botanical works of Nehemiah Grew, F. R. S. (1641-1712) (1973)

Abstract NEHEMIAH GREW was the first English plant anatomist. He was one of that closely knit group of amateur scientists of the seventeenth century who were consciously applying Baconian principles to the exploration of the natural world. The questions they were asking about material things were new questions, of limited and precise range. The answers they found helped to define the scope and content of new sciences, one by one. In this way Grew mapped out the science of botany. In the writings of these men are to be found a strenuous reaching towards a rational view and an attempt to discard the speculations and superstitions of past ages. Yet their work often showed a curious ambivalence, despite their brave words. They were men of both worlds and the old lies embedded undetected beside the new in their philosophy.
Azathioprine or methotrexate in the treatment of patients with steroid‐dependent or steroid‐resistant ulcerative colitis: results of an open‐label study on efficacy and tolerability in inducing and maintaining remission (2002)

Azathioprine is effective in patients with steroid-dependent or steroid-resistant ulcerative colitis. Methotrexate seems to be a good alternative in patients intolerant to or not responding to azathioprine.
Waveguiding and plasmon resonances in two-dimensional photonic lattices of gold and silver nanowires (2008)

We report the fabrication of triangular lattices of parallel gold and silver nanowires of high optical quality, with diameters down to $500\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$ and length-to-diameter ratios as high as 100 000. The nanowires are supported by a silica glass matrix and are disposed around a central solid glass core, i.e., a missing nanowire. These centimeter-long structures make it possible to trap light within an array of nanowires and characterize the plasmon resonances that form at specific optical frequencies. Such nanowire arrays have many potential applications, e.g., imaging on the subwavelength scale.
Some Sulfanilamide Derivatives of Substituted Ethylenediamines<sup>1,2</sup> (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Sulfanilamide Derivatives of Substituted Ethylenediamines1,2George B. Butler and Francis N. McMillanCite this: J. Am. Chem. Soc. 1950, 72, 7, 2978–2979Publication Date (Print):July 1, 1950Publication History Published online1 May 2002Published inissue 1 July 1950https://pubs.acs.org/doi/10.1021/ja01163a047https://doi.org/10.1021/ja01163a047research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Obesity and preeclampsia: the potential role of inflammation*1 (2001)

In women with preeclampsia, there was evidence of increased systemic inflammation in the first trimester. Inflammation might be part of a causal pathway through which obesity predisposes to preeclampsia.
Reduction in nosocomial intravenous device-related bacteremias after institution of an intravenous therapy team. (1996)

In November 1991, an intravenous therapy team was instituted on the medical/surgical wards of a 330-bed acute care Veteran's Affairs Medical Center. Before this, IV insertions/care were performed by house officers and registered nurses. Intravenous-related bacteremias decreased from 4.6/1000 patient discharges to 1.5/1000 patient discharges (P < 0.005) after institution of the IV team. There was no significant difference in the IV-related bacteremia rate in critical care areas where housestaff and nurses continued to care for lines (7.9 versus 6.2 per 1000 patient discharges). The expertise of an IV therapy team is effective in decreasing morbidity and mortality related to IV insertions. The authors estimated a savings of $124,906 when considering reduction of bacteremias.
Chorioallantoic placenta formation in the rat: I. Luminal epithelial cell death and extracellular matrix modifications in the mesometrial region of implantation chambers (1991)

On days 7 and 8 of pregnancy, mesometrial regions of rat gestation sites were examined by light microscopy and transmission electron microscopy to determine what changes occur before the chorioallantoic placenta forms in that region. By day 7, gestation sites contained a uterine lumen mesometrially and an antimesometrial extension of the uterine lumen, the implantation chamber. The implantation chamber consisted of a mesometrial chamber between the uterine lumen and the conceptus, an antimesometrial chamber that contained the conceptus, and a decidual crypt antimesometrial to the conceptus. Stromal cells that formed the walls of the implantation chamber were closely packed decidual cells, while those that surrounded the uterine lumen were loosely arranged. Late on day 7, a portion of the epithelium lining the mesometrial chamber was degenerating, but this area of initial degeneration was never adjacent to the antimesometrial chamber. By early day 8, most of the epithelial cells lining the mesometrial chamber were degenerating and were being sloughed into the chamber lumen. Although degeneration of these epithelial cells morphologically resembled necrosis, it was precisely controlled, since adjacent epithelial cells lining the uterine lumen remained healthy. The space that separated the denuded luminal surface of the mesometrial chamber from underlying decidual cells became wider and was occupied by an extracellular matrix rich in cross-banded collagen fibrils. Decidual cell processes, that earlier had penetrated the basal lamina beneath healthy epithelial cells, protruded into this matrix and penetrated the basal lamina at the luminal surface. By late day 8, large areas of denuded chamber wall were covered with decidual cell processes, little remained of the basal lamina, and cross-banded collagen fibrils were scarce in the area occupied by decidual cell processes. During the times studied, uterine tissues that formed the walls of the mesometrial chamber were not in direct contact with the conceptus. This study indicates that trophoblast does not play a direct role in epithelial degeneration, basal lamina penetration, or extracellular matrix modifications in the mesometrial region of implantation chambers where part of the chorioallantoic placenta forms, although trophoblast may be required to trigger or modulate some of the changes.
Interaction of human plasma low density lipoprotein with concanavalin A and with ricin. (1975)

Native human plasma low density lipoprotein (LDL) interacts with concanavalin A but not with ricin; apOLDL reacts with both lectins. Each reaction is inhibited by the appropriate lectin-specific carbohydrate. The "receptors" on LDL for these two lectins are not destroyed by digestion by proteolytic enzymes. Peptide hydrolysis does not influence the reactivity of LDL toward concanavalin A. It does, however, substantially enhance the ability of the lipoprotein to interact with ricin. The data strongly suggest that the carbohydrate protion of a glycoprotein component of LDL is bound at the saccharidespecific active site on the lectin.
PROMOTION OF INCOMPATIBLE ALLOGRAFT ACCEPTANCE IN RHESUS MONKEYS GIVEN POSTTRANSPLANT ANTITHYMOCYTE GLOBULIN AND DONOR BONE MARROW (1987)

This report extends previous studies demonstrating that prolonged acceptance of incompatible kidney allo-grafts in rhesus monkeys can be achieved by a short recipient rabbit antithymocyte globulin (RATG) treatment course followed by donor bone marrow infusion on day 12 without a requirement for chronic immune-suppression. Serial studies of antilymphocyte cyctotoxic antibody in recipients' sera following RATG injections showed pan-lymphocyte-reactive antibody present until day 10 posttransplant. On days 11 and 12, pan-lymphocyte-reactive antibody was no longer detectable, but cytotoxic antibody specific for mature T cells remained in recipients' sera. These findings might explain the critical time relationship between antithymocyte globulin treatment and donor bone marrow infusion, and further suggest that the tolerance-promoting cell in donor bone marrow is not a mature T cell, but rather a pre-T or a non-T cell. Finally, it was found that this treatment protocol resulted in development of lymphoid nodules in the transplanted kidney that express a CD8-positive, FcIgG-receptor-positive phenotype and appear to be of donor origin. The possibility of a veto cell type of mechanism is discussed as an explanation for the promotion of allograft acceptance in this model.
Synthesis and Characterization of Aluminum Doped Zinc Oxide Nanostructures via Hydrothermal Route (2014)

Stable crystalline aluminum doped zinc oxide (AZO) nanopowders were synthesized using hydrothermal treatment processing. Three different aluminum precursors have been used. The Al-precursors were found to affect the morphology of the obtained nanopowders. AZO nanoparticles based on zinc acetate and aluminum nitrate have been prepared with different Al/Zn molar ratios. XRD investigations revealed that all the obtained powders have single phase zincite structure with purity of about 99%. The effect of aluminum doping ratio in AZO nanoparticles (based on Al-nitrate precursor) on structure, phase composition, and particle size has been investigated. The incorporation of Al in ZnO was confirmed by UV-Vis spectroscopy revealing a blue shift due to Burstein-Moss effect.
Shape selectivity in the adsorption of propane/propene on the all-silica DD3R (1999)

High adsorption selectivity for propene suggests that the all-silica DD3R might be effective as an adsorbent for the separation or purification of propene and propane mixtures.
Guided Tissue Regeneration: An Experimental Procedure in Beagle Dogs (1986)

This preliminary study examined the healing following an experimental procedure designed to facilitate coronal migration of progenitor cells from the periodontal ligament circumferentially on roots of premolar teeth in beagle dogs. Mucoperiosteal flaps were reflected on the buccal and lingual aspects of premolars in six beagle dogs with periodontal disease. Following root preparation, pieces of orthodontic wire were placed interproximally on the crowns to bridge the spaces between teeth. Biobrane, a synthetic membrane bonded to a knitted nylon fabric and coated with collagen, was placed as a physical barrier between the roots and the flaps to be replaced. The membrane extended as a single piece from the cementoenamel junction (CEJ) to overlap the crest of alveolar bone by 3 to 4 mm on both the buccal and lingual surfaces of the three premolars in each quadrant. The membrane was attached to the crowns at the CEJ with resin. The flaps were replaced and sutured. Postoperative care included plaque control and the membranes were removed after 5 weeks. The dogs were sacrificed to provide observation periods of 8 and 16 weeks after placement of membranes. Histologic examination revealed new connective tissue attachment in the apical part of the 8- and 16-week experimental specimens. Some experimental specimens showed new attachment up to 2.94 mm while others showed a long junctional epithelium (JE). Root resorption was also seen in some specimens. These preliminary findings suggest that placement of physical barriers between root surface and flaps may be beneficial in facilitating coronal migration of progenitor cells from the periodontal ligament.