gebhart/patrepeval huggingface dataset:
Cloning and transcriptional analysis of two threonine biosynthetic genes from Lactococcus lactis MG1614 (1996)

Two genes, hom and thrB, involved in threonine biosynthesis in Lactococcus lactis MG1614, were cloned and sequenced. These genes, which encode homoserine dehydrogenase and homoserine kinase, were initially identified by the homology of their gene products with known homoserine dehydrogenases and homoserine kinases from other organisms. The identification was supported by construction of a mutant containing a deletion in hom and thrB that was unable to grow in a defined medium lacking threonine. Transcriptional analysis showed that the two genes were located in a bicistronic operon with the order 5' hom-thrB 3' and that transcription started 66 bp upstream of the translational start codon of the hom gene. A putative -10 promoter region (TATAAT) was located 6 bp upstream of the transcriptional start point, but no putative -35 region was identified. A DNA fragment covering 155 bp upstream of the hom translational start site was functional in pAK80, an L. lactis promoter probe vector. In addition, transcriptional studies showed no threonine-dependent regulation of hom-thrB transcription.
Spallation behaviour of a Zr-bulk metallic glass (2012)

Plate impact experiments have been conducted on a Zr-based bulk metal glass (BMG) using a single stage light gas gun. To understand the spallation process of the material, samples were subjected to dynamic tensile loadings of the same amplitude but different durations. Fractographs of spallation surface and fracture features were characterized and the fracture mechanism of different regions of the spallation surface was discussed. Morphology of the spallation surface in the Zr-BMG exhibited a typical equiaxial cellular pattern and porous microstructure. These experiments revealed that, subjected to hydro-tensile stresses, the microdamage of the spallation occurred in the Zr-BMG is microvoids; the spallation in the Zr-BMG is resulted from nucleation, growth and coalescence of microvoids; and the time needed for these microvoids nucleation is less than 100 ns with a stress amplitude of 3.18 GPa.
Skin cancer in Caucasian renal allograft recipients living in a subtropical climate. (1980)

Between September, 1969, and December, 1978, 290 patients received 325 cadaveric renal allografts; 11 others transplanted elsewhere were also observed. Cancers developed in 28 patients (9.3%); 26 of these (93%) had skin cancers. The incidence of skin cancer increased by 5% annually after the first year of graft function, to a cumulative 44% in those surviving 9 years with functioning grafts. This represents an incidence of 4,356/100,000 person years of post-transplant risk--20.6 times the annual incidence of skin cancer in the general population of Southern Queensland. Half of the patients had multiple tumors when the first skin cancer was diagnosed, after a mean latent interval of 34 months. A total of 138 skin cancers occurred in 26 patients (average, 5.3 per patient), with a maximum of 19 in one individual. The ratio of basal to squamous cell carcinoma was reversed from 4:1, in the general population, to 1:1.7. Conventional surgical excision gave satisfactory results, with the one local recurrence being controlled by reexcision. Two patients (7%) died of melanoma and metastatic squamous cell carcinoma, respectively, whereas two of the other four patients who died from cancer had coincidental skin cancer. The two skin cancer deaths represent only 2% of all deaths in allograft recipients. These results suggest that the problem of skin cancer in these patients can be controlled and thus is not a significant contraindication to the continued clinical use of cadaveric renal transplantation.
Programming iOS 4 (2011)

This is not your typical book on Apple's iOS. Whether you're building iPhone apps for the first time, or want a reference to bolster the Cocoa development skills you already have, this in-depth guide provides a complete learning path from concept to finished product. You'll learn language basics, how to use Xcode and Interface Builder, and all the steps necessary for developing your with the Cocoa framework. What's an Objective-C protocol? What are your code's memory-management responsibilities? How can you make a user interface similar to the iPhone Mail app? How do you prepare your for submission to the App Store? This book covers everything in a rigorous, orderly fashion. It's ideal for beginners with no experience using Apple's tools, as well as experienced iPhone developers who want a comprehensive handbook that details every aspect of the process. * Learn the steps needed to complete an iPhone, iPad, or iPod touch app, from initial concept to the App Store * Become familiar with object-oriented programming concepts * Get up to speed on Objective-C language details * Develop on both the iPhone and iPad platforms, using the universal app approach * Work effectively with Xcode, Interface Builder, and other tools in the iPhone SDK * Get code examples that illustrate each of the concepts and API aspects discussed
Structural Health Management for Future Aerospace Vehicles (2004)

Structural Health Management (SHM) will be of critical importance to provide the safety, reliability and affordability necessary for the future long duration space missions described in America’s Vision for Space Exploration. Long duration missions to the Moon, Mars and beyond cannot be accomplished with the current paradigm of periodic, ground-based structural integrity inspections. As evidenced by the Columbia tragedy, this approach is also inadequate for the current Shuttle fleet, thus leading to its initial implementation of on-board SHM sensing for impact detection as part of the return to flight effort. However, future space systems, to include both vehicles as well as structures such as habitation modules, will require an integrated array of onboard in-situ sensing systems. In addition, advanced data systems architectures will be necessary to communicate, store and process massive amounts of SHM data from large numbers of diverse sensors. Further, improved structural analysis and design algorithms will be necessary to incorporate SHM sensing into the design and construction of aerospace structures, as well as to fully utilize these sensing systems to provide both diagnosis and prognosis of structural integrity. Ultimately, structural integrity information will feed into an Integrated Vehicle Health Management (IVHM) system that will provide real-time knowledge of structural, propulsion, thermal protection and other critical systems for optimal vehicle management and mission control. This paper will provide an overview of NASA research and development in the area of SHM as well as to highlight areas of technology improvement necessary to meet these future mission requirements.
Chondrolysis After Continuous Intra‐Articular Bupivacaine Infusion: An Experimental Model Investigating Chondrotoxicity in the Rabbit Shoulder (2006)

Bupivacaine showed profound chondrotoxic effects in an experimental model that closely followed the current clinical application of postoperative pain pumps. The results caution against the use of such devices in applications for smaller joints with minimal clearance or dilution as a result of hematoma, where continuous exposure of cartilage to bupivacaine is expected.
Increased recombinant protein production in <i>Escherichia coli</i> strains with overexpressed water‐forming NADH oxidase and a deleted ArcA regulatory protein (2006)

Glycolytic flux is increased and acetate production is reduced in Escherichia coli by the expression of heterologous NADH oxidase (NOX) from Streptococcus pneumoniae coupled with the deletion of the arcA gene, which encodes the ArcA regulatory protein. In this study, we examined the overproduction of a model recombinant protein in strains of E. coli expressing NOX with or without an arcA mutation. The presence of NOX or the absence of ArcA reduced acetate by about 50% and increased beta-galactosidase production by 10-20%. The presence of NOX in the arcA strain eliminated acetate production entirely in batch fermentations and resulted in a 120% increase in beta-galactosidase production.
Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine. (1986)

In this study we show that cytarabine given simultaneously with 5-aza-2'-deoxycytidine (Aza-dC) antagonized Aza-dC activity against L1210 mouse leukemia. This antagonism was seen after a single dose (on Day 3 or Day 5 after tumor implant) and after repeated doses. This observation suggests caution in combining cytarabine with Aza-dC in the treatment of human leukemias.
A Mixed‐Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine B (2016)

A novel, mixed-ligand chiral rhodium(II) catalyst, Rh2(S-NTTL)3(dCPA), has enabled the first enantioselective total synthesis of the natural product piperarborenine B. A crystal structure of Rh2(S-NTTL)3(dCPA) reveals a "chiral crown" conformation with a bulky dicyclohexylphenyl acetate ligand and three N-naphthalimido groups oriented on the same face of the catalyst. The natural product was prepared on large scale using rhodium-catalyzed bicyclobutanation/ copper-catalyzed homoconjugate addition chemistry in the key step. The route proceeds in ten steps with an 8% overall yield and 92% ee.
Middle Soap (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMiddle SoapR. H. Ferguson and A. S. RichardsonCite this: Ind. Eng. Chem. 1932, 24, 12, 1329–1336Publication Date (Print):December 1, 1932Publication History Published online1 May 2002Published inissue 1 December 1932https://pubs.acs.org/doi/10.1021/ie50276a002https://doi.org/10.1021/ie50276a002research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Digital focusing of OCT images based on scalar diffraction theory and information entropy (2012)

This paper describes a digital method that is capable of automatically focusing optical coherence tomography (OCT) en face images without prior knowledge of the point spread function of the imaging system. The method utilizes a scalar diffraction model to simulate wave propagation from out-of-focus scatter to the focal plane, from which the propagation distance between the out-of-focus plane and the focal plane is determined automatically via an image-definition-evaluation criterion based on information entropy theory. By use of the proposed approach, we demonstrate that the lateral resolution close to that at the focal plane can be recovered from the imaging planes outside the depth of field region with minimal loss of resolution. Fresh onion tissues and mouse fat tissues are used in the experiments to show the performance of the proposed method.
HLA markers and prediction of clinical course and outcome in rheumatoid arthritis (1997)

While the contribution of HLA typing to establishing the diagnosis of RA is limited, HLA-DR genotyping and DR4 subtype determination provide valuable markers for the prognosis of joint destruction in RA.
A comprehensive study of control design for an autonomous helicopter (1998)

We compare three different control methodologies for helicopter autopilot design: linear robust multivariable control, fuzzy logic control with evolutionary tuning, and nonlinear tracking control. The control design is based on nonlinear dynamic equations with a simplified thrust-torque generation model valid for hovering and low velocity flight. We verify the controller performance in various simulated manoeuvres.
Bringing the Aircraft System Health Management Tool to Life Using the Informatica Tool Suite (2013)

   Earlier this year, UTC Aerospace Systems introduced the Aircraft System Health Management (ASHM) Tool, a web application that takes in Aircraft Condition Monitoring Function (ACMF) reports for selected subsystems and components of an aircraft platform, parses and processes the reported parameters against thresholds and computes estimated or expected values for some key parameters, and serves the report data and the processed results as part of a fleet view available to airline and maintenance users. The ASHM application uses Informatica PowerCenter to parse and store incoming report data and Informatica RulePoint to apply alert rules and analytic processing to the report data as it is persisted to the ASHM database. This paper describes how UTC Aerospace Systems has leveraged a commercial off-the-shelf tool suite rather than continue to build custom components for the ASHM architecture, with the goals of achieving a short development cycle, robust transaction processing, and scalability to other aircraft systems and other aircraft platforms. Instead of building tools from scratch that would need to be reworked as the application scales, a set of scalable tools that suit the task at hand and in the future were selected. The full suite of tools, beyond what has been implemented so far, appears to provide capability to address data integrity, reliability and performance as the application grows.
Lactoferrin three-dimensional structure: a framework for interpreting function. (2000)

Time-lapse in vivo imaging of neuronal structures is critical for understanding the assembly of neural circuits during development. Imaging developing neurons in vivo can be performed with relative ease in lower vertebrates, but ideally, one would also like to image the developing mammalian brain. In vivo chronic imaging of mice is particularly desirable because of the availability of transgenic lines that model human neuropsychiatric disease or those that allow cell- or region-specific expression of fluorescent proteins (e.g., green fluorescent protein [GFP], channelrhodopsins, and genetically encoded calcium indicators). Unfortunately, although chronic imaging of neural structures in adult mice that express GFP is now commonplace, similar approaches in neonatal mice face several additional challenges. First, the small size of the animal complicates the cranial window surgery. Second, there is a tendency for dams to cannibalize pups with head caps. Third, the head cap can impede the normal growth of the skull in neonates, which can limit the duration of imaging. Here, we describe a method for implanting chronic glass-covered cranial windows in the skulls of early postnatal mice through which axonal and dendritic structures can be imaged in vivo over a period of hours or even days.
Explicit vector beam propagation method for uniaxial poled polymer waveguide devices (2002)

For the design and the analysis of integrated optic devices, the beam propagation method (BPM) has been widely used. A vectorial BPM (VBPM) was also developed to simulate the polarization effects and to analyze waveguide structures having large index discontinuities. Recently, the VBPM was extended to treat anisotropic medium by taking the tensorial character of the dielectric constant /spl epsiv/ into account. However, this method using implicit numerical analysis is very complex and needs long computing time. To handle three-dimensional uniaxial waveguide devices that consist especially of a poled electro-optic (EO) polymer waveguide, we developed a new VBPM based on an explicit finite difference (EFD) algorithm. This method is straightforward and easy to program. A novel polarization converter that may be implemented by appropriate poling of the EO polymer waveguide is also proposed and analyzed.
A modified procedure for the preparation of 2,5-dihydropyrrole (3-pyrroline) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA modified procedure for the preparation of 2,5-dihydropyrrole (3-pyrroline)Joseph S. Warmus, Garrett J. Dilley, and A. I. MeyersCite this: J. Org. Chem. 1993, 58, 1, 270–271Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/jo00053a053https://doi.org/10.1021/jo00053a053research-articleACS PublicationsRequest reuse permissionsArticle Views787Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of a 10 kW reflective dish PV system (2002)

A 10 kW reflective dish PV system is under development by SunPower Corporation. Two of these systems are designed for installation at the PVUSA (Photovoltaics for Utility-Scale Application, a consortium of utilities and public entities) test site in CA, USA. The PV modules are monolithic "dense arrays" of ten cells, fabricated and series/parallel connected on a single silicon wafer and mounted on water-cooled cold plates. The cells are point-contact backside silicon, currently of about 20% efficiency at 20 W/cm/sup 2/ [AM 1.5 D, 25 /spl deg/C]. When recent techniques employed in producing smaller cells having 26% efficiency are incorporated, 23.5% module efficiency and 16% system efficiency are projected. The mirrored dish is comprised of 0.3048/spl times/3.048 M (1/spl times/10 ft) curved strips of second-surface low-iron glass mirrors. The tracker is a conventional two-axis design. Focal length is 8.5 m (28 ft); concentration is 250/spl times/. A 1/3-scale 1 kW prototype dish has been built and is undergoing testing at SunPower. This system has demonstrated 13% conversion efficiency at PVUSA rating conditions. Receiver modules are being designed to be applicable in larger central-receiver projects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electromagnetic Two-Dimensional Scanner Using Radial Magnetic Field (2007)

In this paper, we present the design, fabrication, and measurement results of a two-dimensional electromagnetic scanning micromirror actuated by radial magnetic field. The scanner is realized by combining a gimbaled single-crystal-silicon micromirror with a single turn electroplated metal coil, with a concentric permanent magnet assembly composed of two concentric permanent magnets and an iron yoke. The proposed scanner utilizes the radial magnetic field rather than using a lateral magnetic field oriented 45° to the horizontal and vertical scan axes to achieve a biaxial magnetic actuation. The single turn coil fabricated with electroplated copper achieves a nominal resistance of 1.2Ω. A two-dimensional scanner with mirror size of 1.5mm in diameter was fabricated. Maximum optical scan angle of 8.8° in horizontal direction and 8.3° in vertical direction were achieved. Forced actuation of the gimbal at 60 Hz and resonant actuation of the micromirror at 19.1-19.7kHz provide slow vertical scan and fast horizontal scan, respectively. The proposed scanner can be used in raster scanning laser display systems and other scanner applications.
Sucrose Phosphate Glutamate for Combined Transport of Chlamydial and Viral Specimens (1984)

Sucrose phosphate glutamate (SPG) was evaluated as a transport medium for specimens submitted to the virology laboratory. The recovery rate in SPG and minimum essential medium (MEM) was compared at different temperatures and incubation times using herpes viruses. The results showed a successful recovery of viruses from clinical specimens and that SPG is equal to or better than MEM for maintaining herpes virus stability during transport.
Ultraviolet radiation-induced photodegradation and 1O2, O2-. production by riboflavin, lumichrome and lumiflavin. (1989)

Although UVA (320-400 nm) is considered less harmful to skin as compared to UVB (290-320 nm) and UVC (200-290 nm) radiation, certain endogenous chromophores may enhance UVA-induced cutaneous reactions by largely O2-dependent photodynamic reactions. Photodegradation pattern and singlet oxygen (1O2), superoxide anion radical (O2-.) producing capacity of riboflavin (RF), lumiflavin (LF) and lumichrome (LC) were examined to assess their phototoxic potential under UVA. Photolysis of RF upon exposure to UVA, UVB or UVC revealed considerable degradation to LF and LC with a near identical spectral pattern of photodegradation between 250-500 nm. Both LF and LC were stable to UVA (3 J/cm2) and UVB (400 mJ/cm2), whereas RF was photodegraded by 30 and 20%, respectively, under similar irradiation conditions. UVA-sensitized LF and LC respectively, produced nearly 15% higher and 60% lower yield of 1O2 in comparison to RF, whereas, O2-. was generated predominently by RF. Both RF and LF thus appeared to be potential chromophores for evoking deleterious effects of UVA in normal human skin.
An improved wavelet-fractal coder (2002)

In this work, we devise a wavelet-fractal coder where the causal similarity among blocks of different subbands in a wavelet decomposition of the image is exploited. The proposed coding scheme consists of predicting blocks in one subimage from blocks in lower resolution subbands with the same orientation. The experimental results show that the performance of our scheme is superior, for both visual quality and MSE, to that obtainable with standard fractal block coders and also to that of other popular image coders like JPEG.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Informing the Design of Spoken Conversational Search (2018)

We conducted a laboratory-based observational study where pairs of people performed search tasks communicating verbally. Examination of the discourse allowed commonly used interactions to be identified for Spoken Conversational Search (SCS). We compared the interactions to existing models of search behaviour. We find that SCS is more complex and interactive than traditional search. This work enhances our understanding of different search behaviours and proposes research opportunities for an audio-only search system. Future work will focus on creating models of search behaviour for SCS and evaluating these against actual SCS systems.