gebhart/patrepeval huggingface dataset:
Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression (2000)

Reduced gap junction activity has long been implicated in tumorigenesis. To elucidate the potential role of intercellular communication in melanoma development, we examined gap junctional capability of melanocytic cells from various stages of tumor progression in coculture models using dye transfer assays. Normal melanocytes coupled with keratinocytes by gap junctional formation, whereas melanoma cells did not. Instead, melanoma cells communicated among themselves and with fibroblasts. This switch in communication partners coincided with a shift from E-cadherin to N-cadherin expression during melanoma development. Forced expression of E-cadherin by adenoviral gene transfer in N-cadherin-expressing melanoma cells restored gap junctional compatibility with keratinocytes. Our data suggest that (1) melanocyte transformation is associated with loss of the pre-existing gap junctional activity with keratinocytes but a concomitant gain of communication with a newly juxtaposed cell type, the fibroblasts, (2) the specificity of gap junctional formation during melanoma development is determined by the cadherin profile on the melanocytic cells and (3) the overall gap junctional activity of melanocytic cells is not reduced with transformation.
Effects of Intermittent Hypoxia on Cognitive Performance and Quality of Life in Elderly Adults: A Pilot Study (2013)

The data of the current study suggest that an additional intermittent hypoxic training combined with physical exercise augments the positive effects of exercise on cognitive performance and QoL in elderly humans.
Neutron Burst from a High-Voltage Discharge between Palladium Electrodes in D<sub>2</sub>Gas (1990)

A recent experimental observation of a neutron flux burst at a rate of 2 × 104 times the background rate during a high-ac voltage stimulation between two deuterated palladium electrodes in D2 gas is explained in terms of the experimentally measured deuterium-deuterium (D-D) fusion cross sections. Theoretical criteria and experimental conditions for improving D-D fusion rates with the use of pulsed high-dc voltages are described.
[Per- and postoperative complications of TVT (tension-free vaginal tape)]. (2003)

Although a global TVT complication rate of 28.4% in our series may seem high, it should be noted that these complications have a limited morbidity and usually have no consequences. Bladder perforation, haemorrhagic dissection, and urinary retention are the complications most frequently reported (4% to 5%). In this series, a history of pelvic surgery, an associated vaginal surgical procedure, and the operator's experience did not constitute risk factors for complication except in the case of haemorrhagic dissections; a history of pelvic surgery appeared to be a risk factor for intraoperative bleeding. In our experience, it is difficult to evaluate whether or not the type of anaesthesia performed for TVT increases the complication rate.
Robust and Real-time Rotation Estimation of Compound Omnidirectional Sensor (2007)

Camera ego-motion consists of translation and rotation, in which rotation can be described simply by distant features. We present a robust rotation estimation using distant features given by our compound omnidirectional sensor. Features are detected by a conventional feature detector, and then distant features are identified by checking the infinity on the omnidirectional image of the compound sensor. The rotation matrix is estimated between consecutive video frames using RANSAC with only distant features. Experiments with various environments show that our approach is robust and also gives reasonable accuracy in real-time.
Oral Malodor Knowledge Among Myanmar Dental Students and Young Dentists (2019)

Objective: The aim of this study was to evaluate the knowledge of Myanmar dental students and young dentists regarding the diagnosis and treatment of oral malodor. Method: Data were collected from a sample of 120 dental students from the University of Dental Medicine and 21 young dentists in Yangon, Myanmar. They were instructed to answer the structural questionnaires regarding oral malodor knowledge, including the clinical perspective. The content of the questionnaire items ranged from the etiology of oral malodor to treatment regimen. Results: Only 8.5% in the dental students’ group and 14.3% in young dentists’ group correctly answered that tongue coating is the most frequent source of oral malodor when the patients had no severe dental and periodontal problems. Nearly half of the subjects reported that Volatile Sulphur Compounds (VSCs) are related to malodor, but only 18.4% correctly answered the question related to the vulnerable condition of VSCs production. And, around 60% of the subjects didn’t know the reliable diagnostic tools for malodor and more than half of the subjects didn’t know clearly about the oral malodor classifications. Regarding the oral malodor treatment, over 90% of the subjects responded tongue cleaning is essential to reduce oral malodor and 97.2% of the subjects answered that they will provide tooth brushing instructions to oral malodor patients. But, over 70% of the subjects incorrectly recommended saline mouthwash for malodor treatment. Overall, both the dental students and young dentists had less knowledge of oral malodor and most of them responded that they need further knowledge on oral malodor diagnosis and treatment. Conclusion: This study showed that the knowledge of Myanmar dental students and young dentists on oral malodor was a scare. Therefore, it is strongly recommended that dental schools are necessary to give greater emphasis on etiology, diagnosis, and proper treatment for oral malodor.
Antimicrobial<i>N</i>-Halamine Polymers and Coatings: A Review of Their Synthesis, Characterization, and Applications (2013)

Antimicrobial N-halamine polymers and coatings have been studied extensively over the past decade thanks to their numerous qualities such as effectiveness toward a broad spectrum of microorganisms, long-term stability, regenerability, safety to humans and environment and low cost. In this review, recent developments are described by emphasizing the synthesis of polymers and/or coatings having N-halamine moieties. Actually, three main approaches of preparation are given in detail: polymerization, generation by electrochemical route with proteins as monomers and grafting with precursor monomers. Identification and characterization of the formation of the N-halamine bonds (>N-X with X = Cl or Br or I) by physical techniques such as Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), energy-dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), and by chemical reactions are described. In order to check the antimicrobial activity of the N-halamine compounds, bacterial tests are also described. Finally, some examples of application of these N-halamines in the water treatment, paints, healthcare equipment, and textile industries are presented and discussed.
Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis (1991)

We investigated the requirement for cellular cytoskeleton in CR- and FcR-mediated phagocytosis by human monocyte-derived macrophages (M phi). Inhibition of actin microfilament (MF) assembly and stability by cytochalasins B and D completely inhibited M phi phagocytosis of sheep E coated with C3b (EC3b), iC3b (EC3bi), and IgG (EIgG) via CR1, CR3, and FcR, respectively. Ligand-binding to either CR or FcR was not effected by cytochalasins. Nocodazole (NOC), which prevents microtubule (MT) polymerization, and taxol, which causes random polymerization of MT inhibited M phi phagocytosis of EC3b(i) but not EIgG. However, the combination of taxol (5 x 10(-4) M) and NOC (2 x 10(-6) M) augmented M phi CR-mediated phagocytosis. In addition, agents known to increase intracellular cGMP augmented phagocytosis of EC3b(i). Conversely, agents that increase intracellular cAMP inhibited CR-mediated phagocytosis. These agents had no effect on FcR-mediated phagocytosis, and did not effect ligand-binding to CR or FcR. PMA markedly enhanced CR- but not FcR-mediated phagocytosis, and augmentation of CR-mediated phagocytosis by PMA was inhibited by both CD and NOC. In contrast, the synthetic diacylglycerol, 1-oleoyl-2-acetoyl-sn-3-glycerol augmented, and inhibitors of protein kinase C inhibited M phi phagocytosis via CR and FcR. These data indicate that for adherently cultured human M phi: 1) binding of ligand-coated E to CR or FcR does not require an intact cytoskeleton; 2) intact actin microfilament are required for phagocytosis via CR and FcR; 3) phagocytosis via CR1 and CR3 but not FcR is dependent on MT assembly; 4) PMA most likely augments CR-mediated phagocytosis through promotion of MT assembly; and 5) PKC activity is involved in the phagocytic signal generated by both CR and FcR.
Fe - 12 Mn 합금의 수소취성과 수소 농도와의 관계 (1982)

Fe-12% Mn alloy is chosen for this investigation due to its characteristic properties of high susceptibility of hydrogen embrittlement and of strain-induced phase transformation Specimens were heated at 1100℃ for 2 hours and either furnace cooled or water quenched. The results of the X-ray phase determination show that furnace cooled specimen (FC) is having ferrite phase (BCC) only while water quenched specimen (WQ) is observed to contain mostly unstable austenite phase (FCC). Hydrogen concentraton in the two specimens was same and linearly increased with charging time, however, above the concentration level of 15 ppm, WQ had more hydrogen than that of FC with same charging time. With same amount of hydrogen in the specimens, even though WQ showed strain-induced phase transformation, it was less embrittled by hydrogen than FC. When WQ had higher hydrogen concentration, the effect of hydrogen on the embrittlement was greater for WQ than for FC. Impact energy was also greatly reduced with hydrogen content for WQ while the impact property of FC was not influenced by hydrogen. All the experimental results strongly suggest that the phenomenon of hydrogen embrittlement of water quenched Fe-12% Mn alloy is associated with the strain-induced phase transformation along with the processes of the faster hydrogen diffusion in BCC and of forming moledular hydrogen gas pressure due to the excess hydrogen in the transformed BCC.
The biological functions of beta3 integrins. (2004)

Integrins comprise a large family of alphabeta heterodimeric cell-surface receptors that are found in many animal species. They are expressed on a wide variety of cells. There are two members in the beta3 integrin family: alphaIIb beta3 and alpha(v)beta3. This class of adhesion receptors mediates cell-cell and cell-extracellular matrix interactions. Dysregulation of the beta3 integrins is involved in the pathogenesis of many diseases (including cancer) and in transplant rejection. Integrins also play a key role in many virus infectious cycles. In this paper the biological functions of the beta3 family are reviewed, with particular interest in its role in cancer progression and metastasis.
Surface reconstruction from orthogonal contours (2006)

Reconstruction of surface from contours in medical images is often used for modeling. Contouring is usually performed using a single cross-sectional orientation. A potentially more efficient and accurate approach is to use two or more sets of orthogonal contours. In this case, a computational algorithm is needed for reconstructing surface from sets of orthogonal contours. The orthogonal contours are transformed into mesh of 3D polygons. The contours are then resampled using spline interpolation. Finally all possible triangulations for each polygon are evaluated to obtain triangulation. An optimal is selected to reconstruct patch according to a minimum area criteria with constrain on the dihedron angle. All reconstructed patches are combined together to produce a reconstructed surface from orthogonal contours. This method was found to produce surfaces with a smooth and highly realistic appearance.
Modeling human color perception under extended luminance levels (2009)

Display technology is advancing quickly with peak luminance increasing significantly, enabling high-dynamic-range displays. However, perceptual color appearance under extended luminance levels has not been studied, mainly due to the unavailability of psychophysical data. Therefore, we conduct a psychophysical study in order to acquire appearance data for many different luminance levels (up to 16,860 cd/m2) covering most of the dynamic range of the human visual system. These experimental data allow us to quantify human color perception under extended luminance levels, yielding a generalized color appearance model. Our proposed appearance model is efficient, accurate and invertible. It can be used to adapt the tone and color of images to different dynamic ranges for cross-media reproduction while maintaining appearance that is close to human perception.
Mitral Valve Repair at the Time of Continuous-Flow Left Ventricular Assist Device Implantation Confers Meaningful Decrement in Pulmonary Vascular Resistance (2013)

We hypothesized that the addition of mitral valve replacement or repair (MVR) to implantation of continuous-flow left ventricular assist device (cf-LVAD) may further decrease pulmonary vascular resistance (PVR) over Heartmate II (HMII) implantation alone. Patients undergoing MVR with concomitant HMII implantation were compared with those undergoing HMII implantation alone. Of the 57 patients undergoing cf-LVAD implantation, 21 (36.8%) underwent concomitant MVR and 36 (63.2%) underwent cf-LVAD implantation alone. Patients receiving MVR had greater decrement in PVR (59.4% vs. 35.2%, p = 0.01). Decrease in end-diastolic diameter was greater for patients receiving MVR but did not reach statistical significance (18.2 vs. 13.5 mm, p = 0.33). Duration of mechanical ventilation (121.6 vs. 181.4 hours, p = 0.45) and inotropic support (162.4 vs. 153.2 hours, p = 0.86), change in creatinine (0.19 vs. −0.26 mg/dl, p = 0.34), increase in bilirubin (2.54 vs. 1.55 mg/dl, p = 0.63), intensive care unit stay (168.0 vs. 231.5 hours, p = 0.38), and overall length of stay (32.0 vs. 42.5 days, p = 0.75) were similar. There was no difference in survival at 3 months (89.7% vs. 83.3%) and 1 year (83.7 vs. 67.3%, p = 0.34). Addition of MVR may result in greater decrement of PVR than HMII implantation alone. This may permit certain patients thought to be ineligible for transplantation to become candidates.
Edible Films and Coatings: Tomorrow's Packagings: A Review (1998)

(1998). Edible Films and Coatings: Tomorrow's Packagings: A Review. Critical Reviews in Food Science and Nutrition: Vol. 38, No. 4, pp. 299-313.
<i>m</i><i>eso</i>-Aryl-Substituted Expanded Porphyrins (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTmeso-Aryl-Substituted Expanded PorphyrinsJi-Young Shin, Hiroyuki Furuta, Kenji Yoza, Shinetsu Igarashi, and Atsuhiro OsukaView Author Information Department of Chemistry, Graduate School of Science Kyoto University, Kyoto 606-8502, Japan Bruker Japan, Tsukuba, Ibaraki 305-0051, Japan Cite this: J. Am. Chem. Soc. 2001, 123, 29, 7190–7191Publication Date (Web):June 29, 2001Publication History Received12 March 2001Published online29 June 2001Published inissue 1 July 2001https://pubs.acs.org/doi/10.1021/ja0106624https://doi.org/10.1021/ja0106624rapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views4616Altmetric-Citations328LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Conformation,Pyrroles,Reaction mechanisms,X-rays Get e-Alerts
Interpretation of User Comments for Detection of Malicious Websites (2024)

Automated understanding of natural language is a challenging problem, which has remained open for decades. We have investigated its special case, focused on identifying relevant concepts in natural-language text in the context of a specific given task. We have developed a set of general-purpose language interpretation techniques and applied them to the task of detecting malicious websites by analyzing comments of website visitors. In this context, concepts are related to behavior or contents of websites, such as presence of pop-ups and false testimonials. The developed algorithms are based on probabilistic topic models and other dimensionality reduction techniques applied to a special case of multi-label text classification, where concepts are output labels. We integrate information about the target task with other relevant information, including relations among concepts and external knowledge sources using a concept graph. The system iterates between training a topic model on the partially labeled data and optimizing the parameters and the label assignments. We analyze several alternative versions of this mechanism, such as one that measures the quality of separation among topics and eliminates words that are not discriminative. For the task of detecting malicious websites, we have developed an approach that applies machine-learning techniques to the automatically collected data about websites and achieves 98% precision and 95% recall. We present a crowdsourcing system for collecting multiple-choice and free-text comments from website visitors, which is especially useful when other sources of information are insufficient or unreliable. We improve detection performance by considering the text features in the comments about the website. This performance gain is greater when using unstructured free-text comments than using multiple-choice comments. Finally, we have evaluated the performance of our language interpretation framework, and shown that the performance gain from the extracted concepts is related to the popularity of the website and task-based concepts are complementary to text features for obscure websites.
Screening and identification of extractive fermentation solvents using a database (1985)

Abstract The ethanol fermentation has been studied as a model system for end product inhibition and extractive fermentation. Examination has been done on the basis of theoretical considerations, as well as experimental evaluation. For the latter case, a database has been developed in order to screen more than 1,500 solvents for their suitability as extractants in the system solvent‐ethanol‐water. Based on this screening, 62 solvents have been tested with yeast cultures to determine experimentally such important parameters as biocompatibility, distribution coefficients and phase stability. Fifteen of these solvents have proven to be completely biocompatible, while 26 were completely toxic, the remaining solvents showing different degrees of inhibition. In this paper, the theoretical and experimental procedures involved in the systematic screening of extractive fermentation solvents will be outlined. Also, some heuristic criteria will be presented that allow for an evaluation of solvent biocompatibility a priori .
Wall-associated processing of extracellular enzymes of Staphylococcus simulans biovar staphylolyticus (1998)

Staphylococcus simulans biovar staphylolyticus produces a staphylolytic glycylglycine endopeptidase (lysostaphin) and a micrococcolytic endo-β-N-acetylglucosaminidase (hexosaminidase) as proenzymes that are proteolytically processed through multiple intermediates to their mature forms by an extracellular sulfhydryl protease. Analysis of protease production by immunoblots using antiserum prepared against purified protease and by renaturing activity gels using gelatin as the substrate has revealed that the lysostaphin-processing protease also is produced as a proenzyme, which appears to be autocatalytically processed. Very little proprotease could be detected in supernatants from cultures of S. simulans biovar staphylolyticus, which suggested that the protein was being processed before it was released to the culture medium. Analysis of wall-associated proteins revealed that processing of proprotease occurred primarily in the cell wall. Furthermore, processing of prolysostaphin and prohexosaminidase also occurred in the cell wall matrix.
Studies of amine‐induced ring opening of some mesoionic xanthines (1985)

Abstract The ring‐opening reactions of seven mesoionic thiazolo[3,2‐ a ]pyrimidine‐5,7‐diones by a series of primary and secondary amines have been investigated. The rates of the ring fission of five N (8)‐substituted mesoionic xanthines with benzylamine were measured and found to follow second order kinetics. The Hammett relationship is followed with ϱ value of + 0.48 in p ‐dioxane as solvent. The dependence of rates on temperatures has been studied for the N (8)‐ethyl derivative; the energy of activation (Δ E* ) is 25.3 kcals mol −1 , the enthalpy of activation (Δ H* ) is 24.7 kcals mol −1 and the entropy of activation (Δ S* ) is — 4.9 e.u. A slight increase in rate of reaction was observed when the solvent was changed from p ‐dioxane to dimethyl sulfoxide. In p ‐dioxane at constant mesoionic xanthine concentration, the rate constant for ring opening decreased with increasing benzylamine concentration. These results are consistent with a bimolecular nucleophilic mechanism proceeding by the rate‐determining formation of a charged tetrahedral transition state.
Qualifying the Harmfulness of Address Translation (2009)

Address translation is widely considered harmful because its existing
variants conflict with well-established design principles of the
Internet engineering community. Still, address translation has become
common practice despite technical problems because it constitutes an
easy-to-deploy solution to a set of common operational needs. Since
some of these needs will continue to exist in IP version 6, there is
concern within the Internet engineering community about the potential
proliferation of harmful technology from IP version 4 to IP version 6.
This paper investigates these concerns. It analyzes feasible address
translator designs, explains why the problems of address translation,
as used today, are to a significant extent specific to IP version 4,
and shows how the problems can be mitigated in IP version 6.