gebhart/patrepeval huggingface dataset:
Sintering of Zinc Oxide Doped with Antimony Oxide and Bismuth Oxide (1989)

The phase change, densification, and microstructure development of ZnO doped with both Bi 2 O 3 and Sb 2 O 3 are studied to better understand the sintering behavior of ZnO varistors. The densification behavior is related to the formation of pyrochlore and liquid phases; the densification is retarded by the former and promoted by the latter. The pyrochlore phase, whose composition is Bi 3/2 ZnSb 3/2 O 7 , appears below 700°C. The formation temperature of the liquid phase depends on the Sb/Bi ratio: about 750°C for Sb/Bi < 1 by the eutectic melting in the system ZnO—Bi 2 O 3 , and about 1000°C for Sb/Bi > 1 by the reaction of the pyrochlore phase with ZnO. Hence, the densification rate is determined virtually by the Sb/Bi ratio and not by the total amount of additives. The microstructure depends on the sintering temperature. Sintering at 1000°C forms intragrain pyrochlore particles in ZnO grains as well as intergranular layers, but the intragrain particles disappear at 1200°C by the increased amount of liquid phase, which enhances the mobility of the solid second phase.
Effect of low-temperature annealing on transport and magnetism of diluted magnetic semiconductor (Ga, Mn)As (2001)

We report improvements in the crystallinity of a III–V-based diluted magnetic semiconductor (Ga, Mn)As by heat treatment (annealing) after growth at comparatively low temperatures. This method can be used to raise the Curie temperature to 100 K without the need for severe optimization of growth conditions, as well as to adjust the material parameters to desired values.
Pore-Size Distribution in Porous Materials (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPore-Size Distribution in Porous MaterialsL. C. DrakeCite this: Ind. Eng. Chem. 1949, 41, 4, 780–785Publication Date (Print):April 1, 1949Publication History Published online1 May 2002Published inissue 1 April 1949https://pubs.acs.org/doi/10.1021/ie50472a024https://doi.org/10.1021/ie50472a024research-articleACS PublicationsRequest reuse permissionsArticle Views1040Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Deep Gaussian Embedding of Graphs: Unsupervised Inductive Learning via Ranking (2017)

Methods that learn representations of nodes in a graph play a critical role in network analysis since they enable many downstream learning tasks. We propose Graph2Gauss - an approach that can efficiently learn versatile node embeddings on large scale (attributed) graphs that show strong performance on tasks such as link prediction and node classification. Unlike most approaches that represent nodes as point vectors in a low-dimensional continuous space, we embed each node as a Gaussian distribution, allowing us to capture uncertainty about the representation. Furthermore, we propose an unsupervised method that handles inductive learning scenarios and is applicable to different types of graphs: plain/attributed, directed/undirected. By leveraging both the network structure and the associated node attributes, we are able to generalize to unseen nodes without additional training. To learn the embeddings we adopt a personalized ranking formulation w.r.t. the node distances that exploits the natural ordering of the nodes imposed by the network structure. Experiments on real world networks demonstrate the high performance of our approach, outperforming state-of-the-art network embedding methods on several different tasks. Additionally, we demonstrate the benefits of modeling uncertainty - by analyzing it we can estimate neighborhood diversity and detect the intrinsic latent dimensionality of a graph.
PHARMACODYNAMICS OF CYCLOSPORINE-KETOCONAZOLE INTERACTION IN MICE (1987)

We have previously studied the pharmacokinetics of the cyclosporine-ketoconazole interaction and shown that ketoconazole inhibits the metabolism of cyclosporine in mice. In the present study we investigated the pharmacodynamics of the interaction and found that ketoconazole increased the immunosuppressive activity and toxicity of cyclosporine in vivo. Mice were treated orally with cyclosporine (25-200 mg/kg/day), ketoconazole (100 mg/kg/day), drug vehicle, or drug combination for 14 days. Immunosuppression was studied by assaying radiometrically the delayed hypersensitivity response in mice that were sensitized and challenged to keyhole limpet hemocyanin. The dose-response curve for cyclosporine was shifted to the left when cyclosporine and ketoconazole were coadministered compared with treatment with cyclosporine alone. The dose that produced 50% of the maximal immunosuppression (ED50) for cyclosporine alone was 89 mg/kg/day, whereas the ED50 for cyclosporine, when combined with ketoconazole, was 33 mg/kg/day. Ketoconazole alone was not immunosuppressive. Toxicity was measured by the length of survival during a ten-day period of treatment. Animals receiving both drugs had a significantly lower survival: the ten-day survival of animals treated with 200 mg/kg/day of cyclosporine was 100% in the absence of ketoconazole treatment and 62.5% with 100 mg/kg/day of ketoconazole. The results of our study have two important implications. First, the effect of ketoconazole on cyclosporine immunosuppression is quantitatively similar to its effect on cyclosporine kinetics. Because of this two- to three-fold increase in both unchanged cyclosporine blood levels and immunosuppression, our results suggest that unchanged cyclosporine--not its metabolites--is the primary pharmacological agent of cyclosporine in vivo immunosuppression. Second, to avoid cyclosporine-induced nephrotoxicity, it has been recommended that the dosage of cyclosporine be decreased when this drug combination is used clinically. The results of this study suggest that a decrease in cyclosporine dosage will not lower the level of immunosuppression in these patients.
Efficient Data Mining Model Design for a Large Database in the Cloud Computing Environment (2015)

Efficient data mining model design for a large database in the cloud computing environment is studied. For large databases efficiently mining problem, an efficient data mining model in the cloud computing environment based on improved manifold learning algorithms is proposed. The use of nonlinear manifold learning algorithms is able to reduce dimensionality of data vector feature in cloud computing environments, through characteristic extraction module to preprocess data, improved classical manifold learning algorithm is adopted to increase the distance between the data of sample spread intensive area and shorten the distance between the data of sample spread sparse area, prompting even overall distribution of sample database under cloud computing environment, so as to achieve accurate mining for efficient data in cloud computing environment. The experimental results show that the proposed method can accurately mine target data under cloud computing environments, with high efficiency and precision.
An integer ambiguity resolution method for the global positioning system (GPS)-based land vehicle attitude determination (2009)

During attitude determination using a global positioning system (GPS), cycle slips occur due to the loss of lock and noise disturbance. Therefore, the integer ambiguity needs re-computation to isolate the error in carrier phase. This paper presents a fast method for integer ambiguity resolution for land vehicle application. After the cycle slips are detected, the velocity vector is utilized to obtain the rough baseline vector. The obtained baseline vector is substituted into carrier phase observation equations to solve the float ambiguity solution which can be used as a constraint to accelerate the integer ambiguity search procedure at next epochs. The probability of correct integer estimation in the expanded search space is analyzed. Experimental results demonstrate that the proposed method gives a fast approach to obtain new fixed ambiguities while the regular method takes longer time and sometimes results in incorrect solutions.
Human MUC4 Mucin cDNA and Its Variants in Pancreatic Carcinoma (2000)

The human MUC4 gene is not expressed in normal pancreas; however, its dysregulation results in high levels of expression in pancreatic tumors. To investigate the tumor-associated expression, MUC4 cDNA was cloned from a human pancreatic tumor cell line cDNA expression library using a polyclonal antibody raised against human deglycosylated mucin and RT-PCR. Pancreatic MUC4 cDNA shows differences in 12 amino acid residues in the non-tandem repeat coding region with no structural rearrangement as compared with tracheal MUC4. The full-length MUC4 cDNA includes a leader sequence, a serine and threonine rich non-tandem repeat region, a central large tandem repeat domain containing 48 bp repetitive units, regions rich in potential N-glycosylation sites, two cysteine-rich domains, EGF-like domains, and a transmembrane domain. We also report the presence of a new EGF-like domain in MUC4 cDNA, located in the cysteine-rich region upstream from the first EGF-like domain. Four distinct splice events were identified in the region downstream of the central tandem repeat domain that generate three new MUC4 cDNA sequences (sv4, sv9, and sv10). The deduced amino acid sequences of two of these variants lack the transmembrane domain. Furthermore, two unique forms of MUC4 (MUC4/Y and MUC4/X) generated as a result of alternative splicing lack the salient feature of mucins, the tandem repeat domain. A high degree of polymorphism in the central tandem repeat region of MUC4 was observed in various pancreatic adenocarcinoma cell lines, with allele sizes ranging from 23.5 to 10.0 kb. MUC4 mRNA expression was higher in differentiated cell lines, with no detectable expression in poorly differentiated pancreatic tumor cell lines.
Fault detection with multiple observers (1992)

The authors propose to use a set of independent observers to detect faults in communication systems that are modeled by finite-state machines. An algorithm for constructing these observers and a fast real-time fault detection mechanism used by each observer are given. Since these observers run in parallel and independently, one immediate benefit is that of graceful degradation; one failed observer will not cause collapse of the fault management system. In addition, each observer has a simpler structure than the original system and can be operated at higher speed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Investigation of nano lipid vesicles of methotrexate for anti-rheumatoid activity (2012)

Lipid nano vesicles of MTX can be administered by intravenous route, whereby the drug selectively reaches the target site with reduced toxicity to other organs.
Polarography of Glutathione (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarography of GlutathioneW. Stricks and I. M. KolthoffCite this: J. Am. Chem. Soc. 1952, 74, 18, 4646–4653Publication Date (Print):September 1, 1952Publication History Published online1 May 2002Published inissue 1 September 1952https://pubs.acs.org/doi/10.1021/ja01138a060https://doi.org/10.1021/ja01138a060research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 (2014)

The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear. Via a quantitative proteomics approach using the model organism Caenorhabditis elegans, we gained molecular understanding of the physiological changes elicited by metformin exposure, including changes in branched-chain amino acid catabolism and cuticle maintenance. We show that metformin extends lifespan through the process of mitohormesis and propose a signaling cascade in which metformin-induced production of reactive oxygen species increases overall life expectancy. We further address an important issue in aging research, wherein so far, the key molecular link that translates the reactive oxygen species signal into a prolongevity cue remained elusive. We show that this beneficial signal of the mitohormetic pathway is propagated by the peroxiredoxin PRDX-2. Because of its evolutionary conservation, peroxiredoxin signaling might underlie a general principle of prolongevity signaling.
ForNet: A distributed forensics network (2003)

In order to build forensic capabilities into network infrastructure we must first overcome some difficult technical and socio-economic challenges. Technical Challenges Security fails. Thousands of reported security breaches, worms, and viruses attest to this fact. A majority of security breaches are premeditated acts to subvert computing resources and use them to steal identities, share contraband materials, send Spam, or commit fraud across the Internet. With the wide-spread use of intrusion detection systems (IDS) and firewalls, information systems are more tightly guarded than ever before. Ironically,
Novel Kelch-like Protein, KLEIP, Is Involved in Actin Assembly at Cell-Cell Contact Sites of Madin-Darby Canine Kidney Cells (2003)

Dynamic rearrangements of cell-cell adhesion underlie a diverse range of physiological processes, but their precise molecular mechanisms are still obscure. Thus, identification of novel players that are involved in cell-cell adhesion would be important. We isolated a human kelch-related protein, Kelch-like ECT2 interacting protein (KLEIP), which contains the broad-complex, tramtrack, bric-a-brac (BTB)/poxvirus, zinc finger (POZ) motif and six-tandem kelch repeats. KLEIP interacted with F-actin and was concentrated at cell-cell contact sites of Madin-Darby canine kidney cells, where it colocalized with F-actin. Interestingly, this localization took place transiently during the induction of cell-cell contact and was not seen at mature junctions. KLEIP recruitment and actin assembly were induced around E-cadherin-coated beads placed on cell surfaces. The actin depolymerizing agent cytochalasin B inhibited this KLEIP recruitment around E-cadherin-coated beads. Moreover, constitutively active Rac1 enhanced the recruitment of KLEIP as well as F-actin to the adhesion sites. These observations strongly suggest that KLEIP is localized on actin filaments at the contact sites. We also found that N-terminal half of KLEIP, which lacks the actin-binding site and contains the sufficient sequence for the localization at the cell-cell contact sites, inhibited constitutively active Rac1-induced actin assembly at the contact sites. We propose that KLEIP is involved in Rac1-induced actin organization during cell-cell contact in Madin-Darby canine kidney cells.
FAM129B/MINERVA, a Novel Adherens Junction-associated Protein, Suppresses Apoptosis in HeLa Cells (2010)

A recent proteomics study identified FAM129B or MINERVA as a target of the MAP kinase (Erk1/2) signaling cascade in human melanoma cells. Phosphorylation of the protein was found to promote cell invasion and the dissociation of the protein from the cell-cell junctions. Suppression of apoptosis during metastasis is a prerequisite for the survival and spread of cancer cells. During apoptosis, the adherens junctions are disassembled as the dying cell retracts, and new contacts are formed between normal neighboring cells. In this study, we show that FAM129B was cytosolic in exponentially growing HeLa cells but was translocated to the adherens junctions where it colocalized with β-catenin whenever contact between two or more cells was established. Silencing the FAM129B gene expression by specific siRNAs did not induce apoptosis or inhibit the growth of HeLa cells. However, when apoptosis was induced by exposure to TNFα/cycloheximide or other apoptotic signaling molecules, the onset of apoptosis was accelerated 3-4-fold when FAM129B was depleted. Annexin V binding, the inactivation of the DNA repair enzyme, poly(ADP-ribose) polymerase, and the activation of the caspases occurred more rapidly in the cells lacking FAM129B. The rapid induction of apoptosis in FAM129B knockdown cells was reversed by co-transfection with recombinant FAM129B, indicating that its effect on apoptosis was specific. As apoptosis proceeded, FAM129B was degraded and disappeared from the plasma membrane. Thus, one crucial facet of the mechanism by which FAM129B promotes cancer cell invasion is likely to be the suppression of apoptosis.
A novel lightly doped drain polysilicon thin-film transistor with oxide sidewall spacer formed by one-step selective liquid phase deposition (1999)

We have proposed and successfully demonstrated a novel process for fabricating lightly doped drain (LDD) polycrystalline silicon thin-film transistors (TFT's). The oxide sidewall spacer in the new process is formed by a simple one-step selective liquid phase deposition (LPD) oxide performed at 23/spl deg/C. Devices fabricated with the new process exhibit a lower leakage current and a better ON/OFF current ratio than non-LDD control devices. Since the apparatus used for LPD oxide deposition is simple and inexpensive, the new process appears to be quite promising for future high-performance poly-Si TFT fabrication.
Toward Real-World Single Image Super-Resolution: A New Benchmark and A New Model (2019)

Most of the existing learning-based single image superresolution (SISR) methods are trained and evaluated on simulated datasets, where the low-resolution (LR) images are generated by applying a simple and uniform degradation (i.e., bicubic downsampling) to their high-resolution (HR) counterparts. However, the degradations in real-world LR images are far more complicated. As a consequence, the SISR models trained on simulated data become less effective when applied to practical scenarios. In this paper, we build a real-world super-resolution (RealSR) dataset where paired LR-HR images on the same scene are captured by adjusting the focal length of a digital camera. An image registration algorithm is developed to progressively align the image pairs at different resolutions. Considering that the degradation kernels are naturally non-uniform in our dataset, we present a Laplacian pyramid based kernel prediction network (LP-KPN), which efficiently learns per-pixel kernels to recover the HR image. Our extensive experiments demonstrate that SISR models trained on our RealSR dataset deliver better visual quality with sharper edges and finer textures on real-world scenes than those trained on simulated datasets. Though our RealSR dataset is built by using only two cameras (Canon 5D3 and Nikon D810), the trained model generalizes well to other camera devices such as Sony a7II and mobile phones.
High coercivity L10 FePt films with perpendicular anisotropy deposited on glass substrate at reduced temperature (2007)

The microstructures and magnetic properties of FePt films grown at 350°C on glass substrates with MgO (200) intermediate layer and CrRu (200) underlayer were investigated. The film with 1nm MgO intermediate layer showed higher degree of chemical ordering than that with 4nm MgO layer due to the compression of the lattice constant of 1nm MgO intermediate layer along the [100] direction. Isolated FePt particles were formed when nominal thickness of FePt was 4nm. The room temperature coercivity of isolated FePt particles with 1nm MgO intermediate layer was as high as 12kOe, significantly larger than that with 4nm MgO intermediate layer (6.3kOe).
The Effect of Serotonin-Targeting Antidepressants on Neurogenesis and Neuronal Maturation of the Hippocampus Mediated via 5-HT1A and 5-HT4 Receptors (2017)

Antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs) specifically increase serotonin (5-HT) levels in the synaptic cleft and are widely used to treat mood and anxiety disorders. There are 14 established subtypes of 5-HT receptors in rodents, each of which has regionally different expression patterns. Many preclinical studies have suggested that the hippocampus, which contains abundant 5-HT1A and 5-HT4 receptor subtypes in the dentate gyrus (DG), is critically involved in the mechanisms of action of antidepressants. This review article will analyze studies demonstrating regulation of hippocampal functions and hippocampus-dependent behaviors by SSRIs and similar serotonergic agents. Multiple studies indicate that 5-HT1A and 5-HT4 receptor signaling in the DG contributes to SSRI-mediated promotion of neurogenesis and increased neurotrophic factors expression. Chronic SSRI treatment causes functions and phenotypes of mature granule cells (GCs) to revert to immature-like phenotypes defined as a "dematured" state in the DG, and to increase monoamine reactivity at the dentate-to-CA3 synapses, via 5-HT4 receptor signaling. Behavioral studies demonstrate that the 5-HT1A receptors on mature GCs are critical for expression of antidepressant effects in the forced swim test and in novelty suppressed feeding; such studies also note that 5-HT4 receptors mediate neurogenesis-dependent antidepressant activity in, for example, novelty-suppressed feeding. Despite their limitations, the collective results of these studies describe a potential new mechanism of action, in which 5-HT1A and 5-HT4 receptor signaling, either independently or cooperatively, modulates the function of the hippocampal DG at multiple levels, any of which could play a critical role in the antidepressant actions of 5-HT-enhancing drugs.