gebhart/patrepeval huggingface dataset:
PetroChina, Wuhan City Signs Natural Gas Supply Contract (2001)

In mid-November 200 1, PetroChina and Wuhan City, the capital of Hubei Province, signed a contract for natural gas sales and transmission via ZhongxianWuhan pipeline to provide natural gas for the city that is the largest gas consumer of the pipeline. The contract is in line with the take or pay clause of the international convention on natural gas marketing.
Interaction of Bacillus species and Salmonella enterica serovar Typhimurium in immune or inflammatory signaling from swine intestinal epithelial cells1 (2010)

Previous research evaluated a laboratory strain of Bacillus licheniformis (BL) in a model swine epithelium and found it exerted antiinflammatory effects on Salmonella enterica serovar Typhimurium (Sal)-induced secretion of IL-8. The current investigation evaluated the antiinflammatory actions of Bacillus bacteria available commercially as feed additives for the swine industry. Three isolates were obtained from the product, 2 Bacillus subtilis (BS1 and BS3) and 1 BL (BL2). Swine jejunal epithelial IPEC-J2 cells were seeded into wells on permeable membrane supports and allowed to form confluent monolayers. Treatments included apical pretreatment with BL, BS1, BL2, or BS3 for 17 h without Sal, and the same Bacillus treatments but with 10(8) cfu of Sal added in the final hour of Bacillus incubation. Two additional treatments included negative control wells receiving no bacteria (control) and positive control wells receiving only Sal (10 total treatments). After bacterial incubation, wells were washed and fresh medium containing gentamicin was added. Cells were incubated for an additional 5 h, after which apical and basolateral media were recovered for determination of IL-8 and bacitracin. In addition, inserts with epithelial cells that had received Sal were lysed and lysates were cultured to determine treatment effects on Sal invasion. Exposure to Sal alone provoked an increase in IL-8 secretion from IPEC-J2 cells compared with control wells (P < 0.001 for both the apical and basolateral directions). Pretreatment with each Bacillus isolate followed by challenge with Sal reduced Sal-induced IL-8 secretion in both the apical and basolateral compartments compared with wells receiving only Sal (P < 0.001; except for BS3 apical, P < 0.01). The residual presence of bacitracin could be detected only in BL2 and BL2+Sal. Fewer Sal colonies could be cultured from lysates of BL2+Sal than from the Sal, BS1+Sal, and BS3+Sal treatments (P < 0.001). Results indicate that B. subtilis and BL have the ability to intervene in secretion of the neutrophil chemoattractant IL-8 from swine intestinal epithelial cells. This effect on chemokine secretion by gastrointestinal epithelial cells in vitro could not be explained solely by reduced invasion of epithelial cells by Sal.
Reductive Coupling and Polymerization of Unsaturated Amides. II. Effect of Substituents<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductive Coupling and Polymerization of Unsaturated Amides. II. Effect of Substituents1H. R. Snyder and Robert E. PutnamCite this: J. Am. Chem. Soc. 1954, 76, 7, 1893–1898Publication Date (Print):April 1, 1954Publication History Published online1 May 2002Published inissue 1 April 1954https://pubs.acs.org/doi/10.1021/ja01636a047https://doi.org/10.1021/ja01636a047research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium (2011)

In inflammatory bowel diseases (IBD), intestinal barrier function is impaired as a result of deteriorations in epithelial tight junction (TJ) structure. IL-6, a pleiotropic cytokine, is elevated in IBD patients, although the role of IL-6 in barrier function remains unknown. We present evidence that IL-6 increases TJ permeability by stimulating the expression of channel-forming claudin-2, which is required for increased caudal-related homeobox (Cdx) 2 through the MEK/ERK and PI3K pathways in intestinal epithelial cells. IL-6 increases the cation-selective TJ permeability without any changes to uncharged dextran flux or cell viability in Caco-2 cells. IL-6 markedly induces claudin-2 expression, which is associated with increased TJ permeability. The colonic mucosa of mice injected with IL-6 also exhibits an increase in claudin-2 expression. The claudin-2 expression and TJ permeability induced by IL-6 are sensitive to the inhibition of gp130, MEK, and PI3K. Furthermore, expression of WT-MEK1 induces claudin-2 expression in Caco-2 cells. Claudin-2 promoter activity is increased by IL-6 in a MEK/ERK and PI3K-dependent manner, and deletion of Cdx binding sites in the promoter sequence results in a loss of IL-6-induced promoter activity. IL-6 increases Cdx2 protein expression, which is suppressed by the inhibition of MEK and PI3K. These observations may reveal an important mechanism by which IL-6 can undermine the integrity of the intestinal barrier.
Numerical Constitutive Models of Woven and Braided Textile Structural Composites (2002)

Equivalent, three-dimensional elastic moduli are determined from unit cell models of balanced plain weave, 2D braid, 2D triaxial braid and 4x4 twill textile composite materials consisting of interlaced or intertwined yarns. The yarn paths are modeled with undulation portions, in which one yarn passes over and under one or more yarns, and with straight portions. It is assumed that the centerline of a yarn in the undulation portions is described by the sine function, and that the cross-sectional area of a yarn and the thickness of a yarn, normal to the centerline, are uniform along the centerline. For the balanced plain weave architecture, equations for the fiber volume fraction and the cross-sectional shape of the yarn are derived for large crimp angles. It is shown that the maximum crimp angle is limited to forty-five degrees, and that limits on the ratio of the length of the undulation portion of the path to the width of the unit cell impose constraints on the fiber volume fraction and yarn packing density. For small crimp angles, approximations to the volume fraction and yarn shape equations are obtained. This assumption is used in the derivation of the geometry of the remaining architectures, and subsequent equations are obtained for the corresponding geometric parameters. For each architecture, the yarns are assumed to be transversely isotropic and a stress averaging technique based on an iso-strain assumption is used to determine the effective moduli of the unit cells. Comparisons of the effective moduli are made to other unit cell models in the literature. The micromechanical models are implemented in Fortran programs and user material subroutines for ABAQUS, called UMAT, are created out of these programs. For a balanced plain weave fabric under the small crimp angle approximation, a progressive failure model is developed to predict failure within each yarn and to degrade the material properties of the representative unit cell. Material failure is predicted by discretizing the yarns into slices and applying Tsai-Wu quadratic criterion to the on-axis strains in each slice. A stiffness and strength reduction scheme is then used to account for the change in yarn compliance. At the present time, the UMAT has only been tested as a stand-alone program with Visual Fortran 6.0, and would require further development to be used within ABAQUS on sample structural problems.
Fully SMT-compatible optical-I/O package with microlens array interface (2003)

A new optoelectronic package for interchip optical interconnections is presented. To make cost-effective IC-packaging and printed circuit board (PCB) assembly, we strongly emphasize the need for full compatibility with surface-mount technology (SMT). Based on the "OptoBump" interface, which couples the package and PCB by means of an array of wide, collimated beams, we developed two prototype packages: a transmitter package that contains a vertical-cavity surface-emitting laser (VCSEL) array and a driver-IC, and a receiver package that contains a photodiode (PD) array and a receiver-IC. A microlens array is integrated with each package to counteract misalignments that occur in the SMT process. All three output signals, which are E/O (O/E)-converted in the each package, exhibit clear eye diagrams at 1.25 Gb/s after the packages are surface-mounted on a PCB. The influence of polymer encapsulation on a VCSEL and an evaluation of the optical interface provided by the three optical beams on a 500-μm center-to-center spacing are also discussed.
A New Approach to Differential Peripheral Nerve Fiber Block (1983)

Differential block of peripheral nerve fibers was attempted in vitro by a new approach based on inhibiting the membrane pump with ouabain. Sequential concentration dependent extinction of the components of the compound action potential was obtained: C extinguished first, A delta next, A beta last. The sequence conforms to expectations based on axonal size. Because pain is mediated by C and A delta fibers, and block of these groups by ouabain was not reversed readily, further investigation of the practicability of the new approach seems warranted.
High-Speed Electron Beam Data Conversion System Combining Hierarchical Operation with Parallel Processing (1992)

A new high-speed electron beam (EB) data conversion system has been developed for the variable-shaped beam EB reticle writing system EX-8. The target conversion rate from computer-aided design (CAD) data to EX-8 data is five reticles per hour for the class of 16-Mbit dynamic random access memory (DRAM) and beyond. To achieve this, both the hierarchical and parallel shape data operations and the parallel EB formatting have been adopted. Preprocesses for the hierarchical operations have been integrated, such as cell-overlap eliminations and the “doughnut process” which involves partially expanding shapes near cell boundaries. A 64-Mb DRAM design was successfully converted in the hierarchical method on an engineering workstation (EWS) with a single processor, and the number of processed shapes was reduced by four orders of magnitude and the average processing time was less than nine minutes. The processing time of the shape data operations for one layer of a 129 k gate array was reduced to 1/3 when four processes were performed in parallel on an EWS with four processors.
Millimeter-Wave Reflective-Type Phase Shifter in CMOS Technology (2009)

The design and measurement of a compact, wide-band reflective-type phase shifter in 90 nm CMOS technology in V-band frequency is presented. This phase shifter has a fractional bandwidth of 26% and an average insertion loss of 6 dB over all phase states. The chip area is only 0.08 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Measurement results show that the developed phase shifter provides 90 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">°</sup> continuous phase shift over the frequency range of 50-65 GHz. The measured return loss is greater than 12 dB at 50 GHz. The output power is linear up to at least 4 dBm input power.
Slow Adaptive Changes in Urease Levels of Tobacco Cells Cultured on Urea and Other Nitrogen Sources (1980)

Tobacco (cv. Xanthi) XD cells cultured for more than a year on urea as the sole source of nitrogen have urease activities about four times higher than cells which have been cultured on nitrate. When cells which had always been grown on nitrate were transferred to urea, the urease activity in these cells remained at a lower level for eight transfers (40 generations), then gradually increased 4-fold during the next seven to 10 transfers. Cells with high urease activity multiplied 19% more rapidly and accumulated less urea than cells with low urease activity. These findings suggest that elevated urease accelerates urea assimilation; therefore, urea limited growth. Clones of cells with low urease activity responded in the same way as uncloned populations when transferred from nitrate to urea, indicating that high urease cells originate from low urease cells, rather than from a preexisting subpopulation of high urease cells. The urease levels in clones of cells from a population with high urease activity were three to seven times the low urease level. The observed dependence of urease activity on generations of growth on urea was matched with a model in which high urease cells originated at mitosis of low urease cells at a frequency of 8 x 10(-5), then multiplied 19% more rapidly than low urease cells. This frequency is about 10(3) greater than that of other biochemical variants previously isolated from XD cells. The high urease activity gradually declined in cells transferred from urea to other nitrogen sources, but rose rapidly when such cells were returned to urea, indicating the existence within the cells of some form of record of their ancestors' growth on urea. The data indicate the existence of a mechanism for generation, at unusually high frequency, of metastable variants with high urease activity. This mechanism, coupled with enrichment for the variants' progeny by virtue of their higher multiplication rate on urea, can account for the observed slow increase in urease activity of the population. It is suggested that the molecular basis of the urease increase may be gene amplification, based on animal cell models. An alternative hypothesis, namely a specific response induced in all cells by urea and manifested as a very slow adaptive increase in urease, has not been ruled out.
Dichotomy between macrophage activation and degree of protection against Listeria monocytogenes and Toxoplasma gondii in mice stimulated with Corynebacterium parvum (1975)

In vivo and in vitro experiments were conducted to determine the effect of Corynebacterium parvum treatment of mice on resistance of Listeria monocytogenes and Toxoplasma gondii. Intravenous immunization with C. parvum conferred transient protection against intravenous challenge with Listeria or an avirulent strain of Toxoplasma but did not protect against a virulent strain of Toxoplasma. Compared with the level of protection conferred by C. parvum, a higher degree of resistance was noted when mice infected with Listeria or Toxoplasma were challenged with the homologous infecting organism. Peritoneal macrophages from mice immunized intravenously with C. parvum were activated to kill Toxoplasma in vitro. Whereas resistance to challenge in vivo was transient, this population of activated macrophages persisted. Peritoneal macrophages from C. parvum mice also markedly inhibited [3H]thymidine uptake by L cells.
Isolation of Escherichia coli O5 : H − , possessing genes for Shiga toxin 1, intimin-β and enterohaemolysin, from an intestinal biopsy from an adult case of bloody diarrhoea: evidence for two distinct O5 : H − pathotypes (2005)

Two typical coliforms from an intestinal biopsy from an adult case of bloody diarrhoea carried genes encoding intimin-beta, stx(1) and ehxA, and produced verocytotoxin 1 and enterohaemolysin in culture. Both were biochemically typical Escherichia coli O5 :H(-), apart from producing urease. Such O5 isolates represent a human pathogenic E. coli lineage.
From private to public: Alba de Céspedes' agony column in 1950s Italy (2004)

Summary A unique, if problematical, historical source for the study of the ‘private sphere’, the problem page has, as yet, been the subject of little serious attention. This article initially considers the problem page in general terms, and with particular reference to 1950s Italy, a time when a notable feature of the changing patterns of cultural consumption was the emergence and upsurge in popularity of the weekly magazine. The rest of the paper is devoted to an analysis of best-selling author Alba de Céspedes' agony column, ‘Dalla parte di lei’, published in the magazine Epoca . The article shows that the column provides intriguing insights into the state of family and marriage during a time of transition. It discusses the idea of the agony column as a commodity, but also highlights de Céspedes' aim of providing a kind of compendium of lay morals, arguing that any attempt to provide an alternative to the Catholic Church, and the prevailing conservative attitudes of the time, was a matter of careful negotiation.
<title>Composite material defect characterization using leaky Lamb wave dispersion data</title> (1998)

Leaky Lamb wave (LLW) propagation in composite materials has been studied extensively since it was first observed in 1982. The wave is induced using a pitch-catch arrangement and the plate wave modes are detected by identifying minima in the reflected spectra to obtain the dispersion data. The wave behavior in multi-orientation laminates was well documented and corroborated experimentally with a very high accuracy. The sensitivity of the wave to the elastic constants of the material and to its boundary condition led to several studies where the elastic properties were inverted and the characteristics of bonded joint were evaluated. Recently, the authors modified their experimental setup to allow measuring dispersion curves at a significantly higher speed than ever recorded. A set of 20 angles of incidence along a single polar angle of a composite laminate are acquired in about 45 seconds. The reflection spectra are acquired in real time while filtering the high frequency noise providing reliable data at amplitude levels that are significantly lower that were acquired in prior studies. This new method makes the LLW a practical quantitative tool for both inversion of the elastic properties and characterization of flaws. The emphasis of the current study is on the detection and characterization of flaws. The composite is modeled as transversely isotropic and dissipative medium and the effect of flaws is analyzed and compared to the experimental data using a C-scan mounted LLW scanner.
Frequency Response of Long Mass-spectrometer Sampling Catheters (1986)

It was hypothesized that the long lengths of sampling catheters required when a mass spectrometer is multiplexed to more than one operating room limit the upper frequency at which a gas concentration may be determined accurately. This possibility has not been investigated. Known step changes of CO2 were generated by a solenoid valve driven by an electronic timer that was adjustable from 0.1 to 10 Hz. The valve alternated between 100% O2 and 7% CO2 in 50% O2 and balance N2. CO2 concentration was monitored by a mass spectrometer after the gas passed through a 3.7 m Teflon catheter or through 30 m Teflon, nylon, polyethylene (PE), or polyvinylchloride (PVC) catheters. Gas flow for all catheters was adjusted to 1.1 ml/s. The peak-to-peak output of the mass spectrometer was read from a storage oscilloscope. The 3.7 m catheter caused a 10% error at 5.5 Hz (330/min). In sharp contrast, 30 m catheters made from Teflon, PVC, and PE caused errors greater than 10% at only 0.6 Hz (36/min). The 30 m nylon catheter passed 1.1 Hz (66/min) with a 10% error. Teflon, PVC, and PE are not suitable materials from which to make long catheters sampling CO2. Because the frequency response of the nylon catheter appeared similar to that of a low-pass filter, an electronic circuit was designed and tuned to extend the high-frequency response of the catheter. With the circuit in place, the frequency at which a 10% error occurred in the measurement of CO2 improved from 1.1 Hz (66/min) to 2.2 Hz (132/min).(ABSTRACT TRUNCATED AT 250 WORDS)
Digital implementation of a unity-power-factor constant-frequency DCM boost converter (2005)

A DSP implementation of digital control for constant-frequency, unity-power-factor, and discontinuous-conduction-mode boost rectifier is described. By employing variable-duty-cycle control, the power factor of over 0.99 is achieved in the entire universal line-voltage range (90-264 V). In addition, the transient response of the rectifier is optimized by utilizing a nonlinear PI-controller with anti windup that is independently optimized for U.S. line-voltage range (90-132 V) and for European line-voltage range (180-264 V) and by temporarily increasing the bandwidth of the control loop during transients. The performance of the proposed DSP control was verified on a 100-kHz, 400-W unity-power-factor rectifier prototype
Non-invasive methods for the determination of body and carcass composition in livestock: dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging and ultrasound: invited review (2015)

The ability to accurately measure body or carcass composition is important for performance testing, grading and finally selection or payment of meat-producing animals. Advances especially in non-invasive techniques are mainly based on the development of electronic and computer-driven methods in order to provide objective phenotypic data. The preference for a specific technique depends on the target animal species or carcass, combined with technical and practical aspects such as accuracy, reliability, cost, portability, speed, ease of use, safety and for in vivo measurements the need for fixation or sedation. The techniques rely on specific device-driven signals, which interact with tissues in the body or carcass at the atomic or molecular level, resulting in secondary or attenuated signals detected by the instruments and analyzed quantitatively. The electromagnetic signal produced by the instrument may originate from mechanical energy such as sound waves (ultrasound - US), 'photon' radiation (X-ray-computed tomography - CT, dual-energy X-ray absorptiometry - DXA) or radio frequency waves (magnetic resonance imaging - MRI). The signals detected by the corresponding instruments are processed to measure, for example, tissue depths, areas, volumes or distributions of fat, muscle (water, protein) and partly bone or bone mineral. Among the above techniques, CT is the most accurate one followed by MRI and DXA, whereas US can be used for all sizes of farm animal species even under field conditions. CT, MRI and US can provide volume data, whereas only DXA delivers immediate whole-body composition results without (2D) image manipulation. A combination of simple US and more expensive CT, MRI or DXA might be applied for farm animal selection programs in a stepwise approach.