gebhart/patrepeval huggingface dataset:
Development of a remote lab with micro-processor &amp; DSP with FPGA accelerator (2013)

This paper describes and discusses the setting up of a DSP Cloud Lab, a setup to execute programs remotely. The programs can be executed on a variety of DSP boards; they could be microprocessor assembly language programs or programs written in assembly language requiring powerful DSP boards or even DSP boards with an FPGA accelerator. The boards used are based on Blackfin Architecture. For a student / developer who writes codes and tests on it, it appears as if they have exclusive use of the boards. However, the boards are highly shared, enabling a large number of students / developers to use them simultaneously. This paper also discusses the design choices made at different stages and the extent to which it facilitates or restricts the use of the DSP boards for a developer.
Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins (2018)

Large-scale transient expression in mammalian cells is a rapid protein production technology often used to shorten overall timelines for biotherapeutics drug discovery. In this study we demonstrate transient expression in a Chinese hamster ovary (CHO) host (ExpiCHO-S™) cell line capable of achieving high recombinant antibody expression titers, comparable to levels obtained using human embryonic kidney (HEK) 293 cells. For some antibodies, ExpiCHO-S™ cells generated protein materials with better titers and improved protein quality characteristics (i.e., less aggregation) than those from HEK293. Green fluorescent protein imaging data indicated that ExpiCHO-S™ displayed a delayed but prolonged transient protein expression process compared to HEK293. When therapeutic glycoproteins containing non-Fc N-linked glycans were expressed in transient ExpiCHO-S™, the glycan pattern was unexpectedly found to have few sialylated N-glycans, in contrast to glycans produced within a stable CHO expression system. To improve N-glycan sialylation in transient ExpiCHO-S™, we co-transfected galactosyltransferase and sialyltransferase genes along with the target genes, as well as supplemented the culture medium with glycan precursors. The authors have demonstrated that co-transfection of glycosyltransferases combined with medium addition of galactose and uridine led to increased sialylation content of N-glycans during transient ExpiCHO-S™ expression. These results have provided a scientific basis for developing a future transient CHO system with N-glycan compositions that are similar to those profiles obtained from stable CHO protein production systems. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 35: e2724, 2019.
Oculo-facio-cardio-dental (OFCD) syndrome (1996)

Oculo-facio-cardio-dental syndrome consists of (1) eye anomalies: congenital cataract and microphthalmia, or secondary glaucoma, (2) facial abnormalities: (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate, (3) cardiac anomalies: atrial septal defect (ASD), ventricular septal defect (VSD), or floppy mitral valve; and (4) dental abnormalities: canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length. Other less common findings are: sensorineural hearing loss, septate vagina, and syndactyly of toes 2-3. Inheritance may be an X-linked dominant trait, lethal in the male.
Design and evaluation of digital signal processing algorithms for acoustic feedback and echo cancellation (2009)

This thesis deals with several open problems in acoustic echo cancellation and acoustic feedback control. Our main goal has been to develop solutions that provide a high performance and sound quality, and behave in a robust way in realistic conditions. This can be achieved by departing from the traditional ad-hoc methods, and instead deriving theoretically well-founded solutions, based on results from parameter estimation and system identification. In the development of these solutions, the computational efficiency has permanently been taken into account as a design constraint, in that the complexity increase compared to the state-of-the-art solutions should not exceed 50% of the original complexity.Full text available at http://hdl.handle.net/1979/2599
Crop yield estimation by satellite remote sensing (2004)

Abstract Two methods for estimating the yield of different crops in Hungary from satellite remote sensing data are presented. The steps of preprocessing the remote sensing data (for geometric, radiometric, atmospheric and cloud scattering correction) are described. In the first method developed for field level estimation, reference crop fields were selected by using Landsat Thematic Mapper (TM) data for classification. A new vegetation index (General Yield Unified Reference Index (GYURI)) was deduced using a fitted double-Gaussian curve to the National Oceanic and Atmospheric Administration (NOAA) Advanced Very High Resolution Radiometer (AVHRR) data during the vegetation period. The correlation between GYURI and the field level yield data for corn for three years was R 2=0.75. The county-average yield data showed higher correlation (R 2=0.93). A significant distortion from the model gave information of the possible stress of the field. The second method presented uses only NOAA AVHRR and officially reported county-level yield data. The county-level yield data and the deduced vegetation index, GYURRI, were investigated for eight different crops for eight years. The obtained correlation was high (R 2=84.6–87.2). The developed robust method proved to be stable and accurate for operational use for county-, region- and country-level yield estimation. The method is simple and inexpensive for application in developing countries, too. Acknowledgments Our dear friend and colleague, Dr György Tarcsai, died during this long research work, in which he was a very effective partner in the first half of this activity. Let this paper be a small memorial to Gy. Tarcsai. The authors sincerely thank the FÖMI Research Center for their cooperation in the starting phase of this R&D. This work was carried out within the long-range R&D funds of the Hungarian Space Office, and from some special aspects in connection with earlier and actual (T034831, T037611 and F037603) OTKA contracts of the Hungarian Academy of Sciences. Notes †Deceased. Additional informationNotes on contributorsGy. TarcsaiFootnote† †Deceased.
Tight Junctions, Intestinal Permeability, and Autoimmunity (2009)

Autoimmune diseases are characterized by tissue damage and loss of function due to an immune response that is directed against specific organs. This review is focused on celiac disease (CD), an autoimmune enteropathy, and type 1 diabetes (T1D), a hyperglycosaemia caused by a destructive autoimmune process targeting the insulin-producing pancreatic islet cells. Even if environmental factors and genetic susceptibility are clearly involved in the pathogenesis of autoimmunity, for most autoimmune disorders there is no or little knowledge about the causing agent or genetic makeup underlying the disease. In this respect, CD represents a unique autoimmune disorder because a close genetic association with HLA-DQ2 or HLA-DQ8 haplotypes and, more importantly, the environmental trigger (the gliadin fraction of gluten-containing grains wheat, barley, and rye) are known. Conversely, the trigger for autoimmune destruction of pancreatic ss cells in T1D is unclear. Interestingly, recent data suggest that gliadin is also involved in the pathogenesis of T1D. There is growing evidence that increased intestinal permeability plays a pathogenic role in various autoimmune diseases including CD and T1D. Therefore, we hypothesize that besides genetic and environmental factors, loss of intestinal barrier function is necessary to develop autoimmunity. In this review, each of these components will be briefly reviewed.
On the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia materials (2014)

In the clinical application of magnetic hyperthermia, the heat generated by magnetic nanoparticles in an alternating magnetic �耀eld is used as a cancer treatment. The heating ability of the particles is quanti�耀ed by the speci�耀c absorption rate (SAR), an extrinsic parameter based on the clinical response characteristic of power delivered per unit mass, and by the intrinsic loss parameter (ILP), an intrinsic parameter based on the heating capacity of the material. Even though both the SAR and ILP are widely used as comparative design parameters, they are almost always measured in non-adiabatic systems that make accurate measurements dif�耀cult. We present here the results of a systematic review of measurement methods for both SAR and ILP, leading to recommendations for a standardised, simple and reliable method for measurements using non-adiabatic systems. In a representative survey of 50 retrieved datasets taken from published papers, the derived SAR or ILP was found to be more than 5% overestimated in 24% of cases and more than 5% underestimated in 52% of cases.
Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen (1993)

Collagen arthritis is induced in inbred rats with the injection of native type II collagen. The pathogenesis of this experimental autoimmune disease is T cell dependent. This study demonstrates that collagen-specific T cells, derived from pathogenic and nonpathogenic rat T cell lines, both recognize the same peptide epitope. The epitope, consisting of amino acids 58-73 of cyanogen bromide fragment 11 of type II collagen, was as effective as whole collagen in stimulating a panel of collagen-specific rat/mouse T cell hybridomas. This peptide may, therefore, constitute a dominant epitope for CD4+ rat T cells in their response to type II collagen. Administration of the peptide to either neonatal or adult rats prevented the subsequent induction of experimental arthritis with whole collagen, demonstrating that the in vivo response to this dominant epitope is, therefore, relevant in the pathogenesis of arthritis. Despite its ability to prevent collagen-induced arthritis, administration of this peptide in incomplete Freund's adjuvant intradermally did not induce disease.
Differential Stabilization of Eukaryotic DNA Topoisomerase I Cleavable Complexes by Camptothecin Derivatives (1995)

Camptothecins belong to a group of anticancer agents with a specific mechanism of action: stabilization and trapping of eukaryotic DNA topoisomerase I (top1) cleavable complexes. Two water-soluble camptothecin derivatives are in clinical trial, and their anticancer activity appears promising: topotecan and CPT-11. The latter is hydrolyzed to its active metabolite, SN-38. We have previously reported that SN-38 is among the most cytotoxic camptothecin derivatives and that the cleavable complexes induced by SN-38 are more stable than those induced by CPT in human colon carcinoma cells [Tanizawa et al. (1994) J. Natl. Cancer Inst, 86, 836-842]. Top1 inhibition was further investigated by determining the salt-induced religation rates of top1-cleavable complexes in fragments from the top1 cDNA. Religation depended on both the local DNA base sequence and the drug structure. Cleavable complexes induced by SN-38 and 10,11-methylenedioxycamptothecin were markedly more stable (less rapidly reversible) than those induced by CPT, topotecan, and 9-aminocamptothecin. The stability of 10-hydroxycamptothecin-induced cleavable complexes was intermediate to those of CPT and SN-38, indicating that both the 10-hydroxy and the 7-ethyl group of SN-38 probably interact with the drug binding site of top1-cleavable complexes. A DNA oligonucleotide containing a single top1 cleavage site was also used to compare the camptothecin derivatives. The salt stability of drug-induced cleavable complexes in the top1 oligonucleotide was correlated with the drug potencies to induce top1 cleavage. Cell killing requires that trapped cleavable complexes be converted to DNA damage as a result of replication fork collision.(ABSTRACT TRUNCATED AT 250 WORDS)
Legal Frameworks for Energy for Sustainable Development (2005)

Traditional energy production, dependent largely on the burning of biomass in rural areas and the burning of fossil fuels in industrialized areas, poses threats of economic, environmental, and social hardship for the world through global warming and for developing countries through exhaustion on energy-related imports of hard currency resources that are desperately needed for education, sanitation, health care, and other vital human needs.
Design of millimeter-wave wideband gap waveguide transitions considering integration into the antenna system (2015)

Two wideband vertical transitions from inverted microstrip gap waveguide to rectangular waveguide (WR-15) for 60 GHz antenna array applications are proposed. These transitions are aimed to interconnect the WR-15 with the gap waveguide feed-network employed to provide feeding to the radiating elements of slot/horn antenna arrays. The wideband field transformation is achieved without the need of adding a quarter-wavelength cavity backshort on a metal block placed over the transition. First, we replace this backshort by creating a cavity in the radiating layer when this is made in Substrate Integrated Waveguide (SIW) technology, and thereafter we use an air-filled pin cavity in the radiating layer. The simulated Sparameters show that the presented transitions cover the unlicensed 60 GHz band (57–64 GHz) with good margins.
Direct ranking for voltage contingency selection (1989)

The authors present a direct ranking algorithm for contingency selection in power systems taking into consideration voltage security problems. In direct ranking, the performance index for a contingency case is formulated in such a way that detailed knowledge of postcontingency voltages at each individual bus is not necessary. Compared with 1P-1Q iteration screening methods with second norm index, this direct ranking method has a higher computation speed and almost the same accuracy. The proposed algorithm is more concise and can be implemented more efficiently than existing algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effects of Growth Hormone Replacement Therapy on Bone Markers and Bone Mineral Density in Growth Hormone-Deficient Adults (2000)

During the 1990s, interest in the effects of growth hormone deficiency (GHD) in adults increased, and several studies were performed to evaluate the effects of growth hormone (GH) substitution therapy in these patients. Because adults with GHD have reduced bone mineral density (BMD) and an increased risk of fractures, the effects of GH replacement therapy on bone metabolism have been evaluated in long-term studies. A universal finding is that the serum and urinary levels of biochemical bone markers increase during GH substitution therapy, and these increases are dose dependent. After years of GH substitution therapy, the levels of biochemical bone markers remain elevated, according to some studies, whereas other studies report that these levels return to baseline. BMD of the spine, hip and forearm increase after 18–24 months of treatment. Bone mineral content (BMC) increases to a greater extent than BMD, because the areal projection of bone also increases. This difference could be caused by increased periosteal bone formation, but a measurement artefact resulting from the use of dual-energy X-ray absorptiometry cannot be excluded as a possible explanation. One study of GH-deficient adults found that, after 33 months of GH treatment, BMD and BMC increased to a greater extent in men with GHD than in women. There is also a gender difference in the increases in serum levels of insulin-like growth factor I and biochemical bone markers during GH treatment. The reason for these findings is unknown, and the role of sex steroids in determining the response to GH therapy remains to be fully elucidated.
Effects of PYY<sub>3–36</sub> and GLP-1 on energy intake, energy expenditure, and appetite in overweight men (2014)

Our aim was to examine the effects of GLP-1 and PYY3-36, separately and in combination, on energy intake, energy expenditure, appetite sensations, glucose and fat metabolism, ghrelin, and vital signs in healthy overweight men. Twenty-five healthy male subjects participated in this randomized, double-blinded, placebo-controlled, four-arm crossover study (BMI 29 ± 3 kg/m(2), age 33 ± 9 yr). On separate days they received a 150-min intravenous infusion of 1) 0.8 pmol·kg(-1)·min(-1) PYY3-36, 2) 1.0 pmol·kg(-1)·min(-1) GLP-1, 3) GLP-1 + PYY3-36, or 4) placebo. Ad libitum energy intake was assessed during the final 30 min. Measurements of appetite sensations, energy expenditure and fat oxidation, vital signs, and blood variables were collected throughout the infusion period. No effect on energy intake was found after monoinfusions of PYY3-36 (-4.2 ± 4.8%, P = 0.8) or GLP-1 (-3.0 ± 4.5%, P = 0.9). However, the coinfusion reduced energy intake compared with placebo (-30.4 ± 6.5%, P < 0.0001) and more than the sum of the monoinfusions (P < 0.001), demonstrating a synergistic effect. Coinfusion slightly increased sensation of nausea (P < 0.05), but this effect could not explain the effect on energy intake. A decrease in plasma ghrelin was found after all treatments compared with placebo (all P < 0.05); however, infusions of GLP-1 + PYY3-36 resulted in an additional decrease compared with the monoinfusions (both P < 0.01). We conclude that coinfusion of GLP-1 and PYY3-36 exerted a synergistic effect on energy intake. The satiating effect of the meal was enhanced by GLP-1 and PYY3-36 in combination compared with placebo. Coinfusion was accompanied by slightly increased nausea and a decrease in plasma ghrelin, but neither of these factors could explain the reduction in energy intake.
Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4+ and CD8+ T Cell Responses against Mouse Cytomegalovirus Infection (2017)

There is an imperative need for effective preventive vaccines against human cytomegalovirus as it poses a significant threat to the immunologically immature, causing congenital disease, and to the immune compromised including transplant recipients. In this study, we examined the efficacy of synthetic long peptides (SLPs) as a CD4<sup>+</sup> and CD8<sup>+</sup> T cell-eliciting preventive vaccine approach against mouse CMV (MCMV) infection. In addition, the use of agonistic OX40 antibodies to enhance vaccine efficacy was explored. Immunocompetent C57BL/6 mice were vaccinated in a prime-boost vaccination regiment with SLPs comprising various MHC class I- and II-restricted peptide epitopes of MCMV-encoded antigens. Enforced OX40 stimulation resulted in superior MCMV-specific CD4<sup>+</sup> as CD8<sup>+</sup> T cell responses when applied during booster SLP vaccination. Vaccination with a mixture of SLPs containing MHC class II epitopes and OX40 agonistic antibodies resulted in a moderate reduction of the viral titers after challenge with lytic MCMV infection. Markedly, the combination of SLP vaccines containing both MHC class I and II epitopes plus OX40 activation during booster vaccination resulted in polyfunctional (i.e., IFN-γ<sup>+</sup>, TNF<sup>+</sup>, IL-2<sup>+</sup>) CD4<sup>+</sup> and CD8<sup>+</sup> T cell responses that were even higher in magnitude when compared to those induced by the virus, and this resulted in the best containment of virus dissemination. Our results show that the induction of strong T cell responses can be a fundamental component in the design of vaccines against persistent viral infections.
An encapsulation process by sol-gel method for magnetic metal powder. (1987)

金属アルコキシドを原料としたゾル.ゲル法による被膜形成を磁性金属粒子の単核カプセル化に適用し,得られたカプセル粉体を圧縮成形することにより高周波用圧粉鉄心材料を作成した。個々の金属粒子をゲル状連続膜で被覆するには,0.5μm以下の薄膜を形成することが必要で,1μm以上に厚膜化した部分では割れが生じた。とくに金属粒子表面に大きな凹部が存在すると厚膜化と割れの原因になった。調整したカプセルから得た成形体の密度はカプセル化していない金属粒子の成形体と同等であり,磁束密度としては磁化力16kA.m-1で1.2Tが得られた。また,1MHzを越える周波数帯域まで初透磁率が低下せず,金属粒子間の絶縁が良好であることが確認された。このことから,形成した被膜は圧縮成形時の粒子間摩擦に対してはく離せず,厚膜部分や割れは絶縁効果に大きな影響を与えなかったと判断される。本実験のカプセル調整により,高周波特性のすぐれた鉄心材料を作成できることがわかった。
Tomographic reconstruction with adaptive sparsifying transforms (2014)

A central problem in computed tomography (CT) imaging is to obtain useful, high-quality images from low-dose measurements. Methods that exploit the sparse representations of tomographic images have long been known to improve the quality of reconstructions from low-dose data. Recent work has shown that sparse representations learned directly from the data can outperform traditional, fixed representations, but are prohibitively expensive for practical use in CT. We propose a new method for tomographic reconstruction from low-dose data by combining the statistically weighted data fidelity term with an adaptive sparsifying transform regularizer. This regularizer can be fit to the data at lower cost than competing methods. Our algorithm alternates between reconstructing the image and learning the sparsifying transform. The Alternating Direction Method of Multipliers technique is used to provide an efficient solution to the statistically weighted minimization problem. Numerical experiments on data from clinical CT reconstructions indicate that adaptive sparsifying transform regularization outperforms synthesis sparsity methods at speeds rivaling total-variation regularization.
Saturated heterocycles. <b>251</b>. Determination of σ<sup>+</sup> values of heteroaryl‐substituted phenyl groups <i>via</i> ring‐chain tautomerism (1997)

Abstract The Hammett‐Brown electrophilic substituent constants σ + for five heteroaryl‐substituted phenyl groups were estimated via the ring‐chain tautomeric equilibria of three sets of oxazolidines and 1,3‐oxazines in deuteriochloroform solution. For oxazolidines derived from norephedrine and norpseudoephedrine, the σ + values were also determined via the gas‐phase ring‐chain equilibria, by means of mass spectrometry. The results show that the heteroaromatic substituents studied have a slight electron‐withdrawing character, with σ + in the range ‐0.03 to 0.59. The gas‐phase σ + values are significantly higher than the solution values.
Unsupervised Adversarial Depth Estimation Using Cycled Generative Networks (2018)

While recent deep monocular depth estimation approaches based on supervised regression have achieved remarkable performance, costly ground truth annotations are required during training. To cope with this issue, in this paper we present a novel unsupervised deep learning approach for predicting depth maps and show that the depth estimation task can be effectively tackled within an adversarial learning framework. Specifically, we propose a deep generative network that learns to predict the correspondence field (i.e. the disparity map) between two image views in a calibrated stereo camera setting. The proposed architecture consists of two generative sub-networks jointly trained with adversarial learning for reconstructing the disparity map and organized in a cycle such as to provide mutual constraints and supervision to each other. Extensive experiments on the publicly available datasets KITTI and Cityscapes demonstrate the effectiveness of the proposed model and competitive results with state of the art methods. The code is available at https://github.com/andrea-pilzer/unsup-stereo-depthGAN.