gebhart/patrepeval huggingface dataset:
Magnetic Acceleration of Inhaled and Exhaled Flows in Breathing (2000)

Time dependence of the velocity of inhalation and exhalation in breathing was measured in the presence and absence of a magnetic field. When a U-shaped permanent magnet of central magnetic strength 0.7 T was set around the location of air intake, the average velocity of inhaled and exhaled flows increased by about 23%. When a permanent magnet was brought in contact with the nose and a magnetic field was applied inside a nostril, the average velocity increased by about 18%. Magnetic acceleration was efficient when air flowed into a narrower space in the direction of increasing magnetic field strength. The present study suggests a novel method which assists breathing.
Inverse inference in the asymmetric Ising model (2013)

Des techniques expérimentales récentes ont donné la possibilité d'acquérir un très grand nombre de données concernant des réseaux biologiques complexes, comme des réseaux de neurones, des réseaux de gènes et des réseaux d'interactions de protéines. Ces techniques sont capables d'enregistrer les états des composantes individuelles de ces réseaux (neurones, gènes, protéines) pour un grand nombre de configurations. Cependant, l'information la plus pertinente biologiquement se trouve dans la connectivité de ces systèmes et dans la façon précise avec laquelle ces composantes interagissent, information que les techniques expérimentales ne sont pas au point d'observer directement. Le bût de cette thèse est d'étudier les méthodes statistiques nécessaires pour inférer de l'information sur la connectivité des réseaux complexes en partant des données expérimentales. Ce sujet est traité par le point de vue de la physique statistique, en puisant de l'arsenal de méthodes théoriques qui ont été développées pour l'étude des verres de spins. Les verres de spins sont des exemples de réseaux à variables discrètes qui interagissent de façon complexe et sont souvent utilisés pour modéliser des réseaux biologiques. Après une introduction sur les modèles utilisés ainsi qu'une discussion sur la motivation biologique de cette thèse, toutes les méthodes d'inférence de réseaux connues sont présentées et analysées du point de vue de leur performance. Par la suite, dans la troisième partie de la thèse, un nouvelle méthode est proposée qui s'appuie sur la remarque que les interactions en biologie ne sont pas nécessairement symétriques (c'est-à-dire l'interaction entre les noeuds A et B n'est pas la même dans les deux directions). Il est démontré que cette assomption conduit à des méthodes qui sont capables de prédire les interactions de façon exacte, étant donné un nombre suffisant de données, tout en utilisant un temps de calcul polynomial. Ceci est un résultat original important car toutes les autres méthodes connues sont soit exactes et non-polynomiales soit inexactes et polynomiales.
Size Exclusion Chromatography To Gain Insight into the Complex Formation of Carrot Pectin Methylesterase and Its Inhibitor from Kiwi Fruit As Influenced by Thermal and High-Pressure Processing (2009)

A size exclusion chromatography (HPSEC) method was implemented to study complex formation between carrot pectin methylesterase (PME) and its inhibitor (PMEI) from kiwi fruit in the context of traditional thermal and novel high-pressure processing. Evidence was gained that both thermal and high-pressure treatments of PME give rise to two distinct enzyme subpopulations: a catalytically active population, eluting from the size exclusion column, and an inactive population, aggregated and excluded from the column. When mixing a partly denatured PME sample with a fixed amount of PMEI, a PME-PMEI complex peak was observed on HPSEC, of which the peak area was highly correlated with the residual enzyme activity of the corresponding PME sample. This observation indicates complex formation to be restricted to the active PME fraction. When an equimolar mixture of PME and PMEI was subjected to either a thermal or a high-pressure treatment, marked differences were observed. At elevated temperature, enzyme and inhibitor remained united and aggregated as a whole, thus gradually disappearing from the elution profile. Conversely, elevated pressure caused the dissociation of the PME-PMEI complexes, followed by a separate action of pressure on enzyme and inhibitor. Remarkably, PMEI appeared to be pressure-resistant when compressed at acidic pH (ca. 4).
Validation of the DLW method in Japanese quail at different water fluxes using laser and IRMS (2002)

In Japanese quail (Coturnix c. japonica; n = 9), the doubly labeled water (DLW) method ((2)H, (18)O) for estimation of CO(2) production (l/day) was validated. To evaluate its sensitivity to water efflux levels (r(H(2))O(e); g/day) and to assumptions of fractional evaporative water loss (x; dimensionless), animals were repeatedly fed a dry pellet diet (average r(H(2))O(e) of 34.8 g/day) or a wet mash diet (95.8 g/day). We simultaneously compared the novel infrared laser spectrometry (LS) with isotope ratio mass spectrometry. At low r(H(2))O(e), calculated CO(2) production rate exhibited little sensitivity to assumptions concerning x, with the best fit being found at 0.51, and only little error was made employing an x value of 0.25. In contrast, at high r(H(2))O(e), sensitivities were much higher with the best fit at x = 0.32. Conclusions derived from isotope ratio mass spectrometry and LS were similar, proving the usefulness of LS. Within a threefold range of r(H(2))O(e), little error in the DLW method is made when assuming one single x value of 0.25 (recommended by Speakman JR, Doubly Labelled Water. Theory and Practice. London: Chapman & Hall, 1997), indicating its robustness in comparative studies.
Geographically masking health data to preserve confidentiality (1999)

The conventional approach to preserving the confidentiality of health records aggregates all records within a geographical area that has a population large enough to ensure prevention of disclosure. Though this approach normally protects the privacy of individuals, the use of such aggregated data limits the types of research one can conduct and makes it impossible to address many important health problems. In this paper we discuss the design and implementation of geographical masks that not only preserve the security of individual health records, but also support the investigation of questions that can be answered only with some knowledge about the location of health events. We describe several alternative methods of masking individual-level data, evaluate their performance, and discuss both the degree to which we can analyse masked data validly as well as the relative security of each approach, should anyone attempt to recover the identity of an individual from the masked data. We conclude that the geographical masks we describe, when appropriately used, protect the confidentiality of health records while permitting many important geographically-based analyses, but that further research is needed to determine how the power of tests for clustering or the strength of other associative relationships are adversely affected by the characteristics of different masks.
Study of all-trans Retinoic Acid on Growth and Damage of Porcine Normal Thyroid Cells (2005)

Objective To investigate the effect of all-trans Retinoic acid (atRA) on the growth and damage in porcine thyroid gland. Methods Thyroid cells obtained from porcine were cultured in a monolayer system.MTT proliferation assay were used to detect the growth function of thyrocytes.Lactate dehydrogenease were used to detect the damage effect of thyrocytes. Results atRA inhibited thyrocyte growth and injured thyrocyte in a dose-dependent manner. Conclusions atRA is of cytotoxicity in thyroid.
Adult Bone Marrow Cell Therapy Improves Survival and Induces Long-Term Improvement in Cardiac Parameters (2012)

Transplantation of adult BMCs improves LV function, infarct size, and remodeling in patients with ischemic heart disease compared with standard therapy, and these benefits persist during long-term follow-up. BMC transplantation also reduces the incidence of death, recurrent myocardial infarction, and stent thrombosis in patients with ischemic heart disease.
Effect of different concentrations of EDTA on smear removal and collagen exposure in periodontitis‐affected root surfaces (1997)

The purpose of the present study was to explore the possibility of obtaining an acceptable smear-removing and collagen-exposing effect following EDTA etching with concentrations lower than supersaturation (24%). A flat dentin surface was created on human teeth extracted due to severe periodontitis. The teeth were etched with the following concentrations of EDTA for 2 min: 1.5% (group I), 5% (group II), 15% (group III) and 24% (group IV), and evaluated with scanning electron microscopy with respect to smear layer removal and exposure of root-associated collagen fibers. It was found that neither 1.5% nor 5% EDTA etching was sufficient to dissolve the smear layer to any higher degree. Etching with 15% EDTA dissolved the smear more effectively than the lower concentrations and collagen fibers were sparsely found. Following etching with 24% EDTA (group IV), significantly less smear was seen on the dentin surfaces than in any of the other groups and collagen fibers were seen covering the entire intertubular dentin surfaces. Based on these findings, the concentration of EDTA should be somewhere between 15 to 24% in order to obtain an acceptable smear removing and collagen-exposing effect within a clinically acceptable time period.
Functional acrylic monomers as modifiers for PVC plastisol formulations (1990)

Abstract Functional acrylic monomers are used as coagents with polyvinyl chloride plastisols to improve abrasion resistance, tensile strength, chemical resistance, permanent set, hardness, and adhesion. The emphasis of this paper is on the enhancement of physical properties which can be achieved through addition of a variety of different functional acrylic monomers (mono‐, di‐, and tri‐functional) to a PVC plastisol formulation. Collected test data will be given to show the effect these monomers have on the plastisol's physical properties.
Throughput and ergodic capacity of wireless energy harvesting based DF relaying network (2014)

In this paper, we consider a decode-and-forward (DF) relaying network based on wireless energy harvesting. The energy constrained relay node first harvests energy through radio-frequency (RF) signals from the source node. Next, the relay node uses the harvested energy to forward the decoded source information to the destination node. The source node transfers energy and information to the relay node through two mechanisms, i) time switching-based relaying (TSR) and ii) power splitting-based relaying (PSR). Considering wireless energy harvesting constraint at the relay node, we derive the exact analytical expressions of the achievable throughput and ergodic capacity of a DF relaying network for both TSR and PSR schemes. Through numerical analysis, we study the throughput performance of the overall system for different system parameters, such as energy harvesting time, power splitting ratio, and signal-to-noise-ratio (SNR). In particular, the throughput performance of the PSR scheme outperforms the throughput performance of the TSR scheme for a wide range of SNRs.
Single stage transmission type broadband solar concentrator (2010)

In this paper, a single stage solar cell concentrator is designed and discussed. The proposed concentrator consists of refraction prisms and total internal reflection prisms in the inner and outer areas, respectively. In order to compensate for dispersion, all odd zones gather the light onto the -D position, while all even zones gather the light onto the + D position. Finally, the hybrid concentrator achieves optical efficiency of 89.8% for normally incident light without an antireflection coating. An acceptance angle of +/- 0.78 degree at 1 dB loss is achieved without using additional secondary optics. In addition, the fabrication tolerance is also analyzed.
Sulfoxide-carbodiimide reactions. VI. Synthesis of 2'-and 3'-ketouridines (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfoxide-carbodiimide reactions. VI. Synthesis of 2'-and 3'-ketouridinesAlan Frederick. Cook and John G. MoffattCite this: J. Am. Chem. Soc. 1967, 89, 11, 2697–2705Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/ja00987a036https://doi.org/10.1021/ja00987a036research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits (1998)

A novel protein complex has been identified in human cells that has a molecular mass of approximately 450 kDa. It consists of at least eight different subunits including JAB1, the Jun activation-domain binding protein 1, and Trip15, the thyroid hormone receptor-interacting protein 15. The purified complex contains COP9 and COP11 protein homologs and is very similar, if not identical, to the plant COP9 complex involved in light-mediated signal transduction. The isolated JAB1-containing particle has kinase activity that phosphorylates IkappaBalpha, the carboxy terminus of p105, and Ser63 and/or Ser73 of the amino-terminal activation domain of c-Jun. The phosphorylation of c-Jun requires the carboxy terminus of the protein containing the DNA binding and dimerization domains. Three subunits of the new complex--Sgn3, Sgn5/JAB1, and Sgn6--exhibit sequence similarities to regulatory components of the 26S proteasome, which could indicate the existence of common substrate binding sites. Immunofluorescence staining reveals that the new complex shows a subcellular distribution similar to that of the 26S proteasome. The functional relationship of the two particles in regulating transcriptional activity is discussed. Considering the putative role of the complex in signal transduction and its widespread occurrence, we suggest the name JAB1-containing signalosome.
Multiplexing Bragg gratings using combined wavelengthand spatial divisiontechniques with digital resolution enhancement (1997)

A novel multiplexing technique is described, which employs an imaging spectrograph to interrogate fibre Bragg gratings in multiple fibre channels simultaneously, and digital algorithms to enhance the spectral resolution. An equivalent strain sensing resolution of 1.6 µɛ has been achieved in the preliminary experiments.
The Future of New and Genetically Modified Oil Crops (1999)

Oil crops are one of the most valuable traded agricultural commodities and are probably worth over $100 billion/yr. The current volume of traded vegetable oils is over 70 Mt per year and is predicted to increased to over 100 Mt per year by the year 2010 (Murphy 1996). This is probably a considerable underestimate of the total volume of oil production since, particularly in developing countries, most vegetable oils are consumed locally, rather than entering into trading networks. Despite the large volume of globally traded vegetable oil, only four major crops, soybean, oil palm, rapeseed, and sunflower contribute about 75 % of this production. The domination of the oilseed market by the “big four ” oil crops is set to continue for the foreseeable future. Indeed, the establishment of new plantations in South East Asia is predicted to double oil palm production in the next 15 years, making it, by then, the most important source of vegetable oils in the world. The vast majority of vegetable oils are currently used for edible commodities, such as margarines, cooking oils, and processed foods. Only about 15 % of production goes towards the manufacture of oleochemicals, i.e. industrial products derived from oil crops. Over the next few decades two important factors will contribute to an expansion in the markets for both edible and industrial oil crops. Firstly, according to current demographic trends, the global human population will at least double before stabilizing at some time in the mid 21st century. This, coupled with rising levels of affluence in many developing countries, will lead to increased
Data mining for improved cardiac care (2006)

Cardiovascular Disease (CVD) is the single largest killer in the world. Although, several CVD treatment guidelines have been developed to improve quality of care and reduce healthcare costs, for a number of reasons, adherence to these guidelines remains poor. Further, due to the extremely poor quality of data in medical patient records, most of today's healthcare IT systems cannot provide significant support to improve the quality of CVD care (particularly in chronic CVD situations which contribute to the majority of costs).We present REMIND, a Probabilistic framework for Reliable Extraction and Meaningful Inference from Nonstructured Data. REMIND integrates the structured and unstructured clinical data in patient records to automatically create high-quality structured clinical data. There are two principal factors that enable REMIND to overcome the barriers associated with inference from medical records. First, patient data is highly redundant -- exploiting this redundancy allows us to deal with the inherent errors in the data. Second, REMIND performs inference based on external medical domain knowledge to combine data from multiple sources and to enforce consistency between different medical conclusions drawn from the data -- via a probabilistic reasoning framework that overcomes the incomplete, inconsistent, and incorrect nature of data in medical patient records.This high-quality structuring allows existing patient records to be mined to support guideline compliance and to improve patient care. However, once REMIND is configured for an institution's data repository, many other important clinical applications are also enabled, including: quality assurance; therapy selection for individual patients; automated patient identification for clinical trials; data extraction for research studies; and to relate financial and clinical factors. REMIND provides value across the continuum of healthcare, ranging from small physician practice databases to the most complex hospital IT systems, from acute cardiac care to chronic CVD management, and to experimental research studies. REMIND is currently deployed across multiple disease areas over a total of 5,000,000 patients across the US.
Soybean Photoperiod‐Sensitivity Loci Respond Differentially to Light Quality (1996)

Soybean [ Glycine max (L.) Merr.] genotypes have been identified that show differential sensitivity to light quality. The use of different lamp types emitting light of different quality changed flowering responses to long days. The objective of this study was to investigate the flowering response of three photoperiod‐sensitivity loci to long days of various light qualities. ‘Harosoy’ near‐isogenic lines were grown under 20‐h‐long days of different light qualities, as measured by the bichromatic ratio of red to far‐red quanta (R:FR), and under light quality gradients. Generally, the photoperiodic response was greater, i.e., later flowering, with decreased R:FR. The E l allele was most sensitive to light quality and required an R:FR approximating that of natural daylight for response to long days. The E 3 allele was the least sensitive, and the E 4 allele showed intermediate sensitivity to light quality. The earliest‐flowering near‐isogenic line ( e 1 e 3 e 4 ), previously found to be insensitive to long day length, showed sensitivity to long days of low R:FR light. Long days of high R:FR light were not effective in delaying flowering for some genotypes. Sensing the R:FR ratio is the function of phytochrome in light‐grown plants. The three loci studied in this work responded differentially to changes in R:FR, suggesting either a close relationship between soybean E alleles and phytochrome or the possibility that some photoperiod‐sensitivity loci are part of the phytochrome family of genes.
Distinct Molecular Portraits of Human Failing Hearts Identified by Dedicated cDNA Microarrays (2004)

With this pilot feasibility study we demonstrated a novel classification of end-stage heart failure patients, which encourages further development of this approach in prospective studies on heart failure patients at earlier stages of the disease.
A New Titanium Complex Having Two Phenoxy-Imine Chelate Ligands for Ethylene Polymerization (2002)

A new titanium complex having two phenoxy-imine chelate ligands, bis[N-(3-tert-butylsalicylidene)anilinato]titanium(IV)dichloride 1, was synthesized and its structure determined by X-ray analysis. Density functional theory (DFT) calculations and X-ray analysis suggest that complex 1, when activated, possesses two available cis-located sites needed for ethylene polymerization. Complex 1/methylaluminoxane (MAO) in toluene or heptane solvent displayed very high ethylene polymerization activities (2 280–4 150 (kg PE)·(mol cat)–1·h–1) with high molecular weight values (M̄v = 288 000–881 000) at 25–75°C under atmospheric pressure. The activity values displayed by complex 1/MAO are some of the highest values exhibited by any titanium complex with no cyclopentadienyl (Cp) ligand(s). Alternatively, complex 1/iBu3Al/Ph3CB(C6F5)4 in toluene solvent displayed high ethylene polymerization activities (190–670 (kg PE)· (mol cat)–1·h–1) with exceptionally high molecular weight values (M̄v = 3 920 000–5 860 000) at 25–75°C under atmospheric pressure. The molecular weight values displayed by complex 1/iBu3Al/Ph3CB(C6F5)4 are some of the largest values displayed by homogeneous olefin polymerization catalysts including the group 4 metallocenes. The high potential of complex 1 for ethylene polymerization has therefore been demonstrated.
Herpes simplex virus type 1 polypeptide ICP4 bends DNA (1992)

ICP4, the major regulatory polypeptide of herpes simplex virus type 1, is expressed at the earliest stages of virus infection and is required for the activation of transcription from the majority of viral promoters. It is a DNA binding protein which specifically recognises bipartite sites related to the sequence ATCGTnnnnnCGG. In this report we show that both partially purified ICP4, and its isolated DNA binding domain, bend DNA at occupied binding sites. The apparent angles of bend at two different binding sites were very similar and in both cases the centre of the bend was very close to the binding site sequence.