gebhart/patrepeval huggingface dataset:
Hepatitis C virus infection and liver disease: Peculiar epidemiological and clinicopathological features (1994)

t: Hepatitis C virus (HCV) infection is associated with a wide spe e forms of chronic hepatitis. HCV is not invariably pathogenic an /ariability. In clinical practice this means that presence and repli mage. IgM antibodies that are the best diagnostic tools for the c for hepatitis C, therefore we have to look for alternatives. Dete infections and only anti-HCV seroconversion in previously negat aificant association between serum anti-Cl00-3 and HCV-RN/ of HCV infectivity. In anti-HCV-negative infections and early a iagnostie alternative. In patients undergoing antiviral therap NA by quantitative assays represent a valid tool to predict re :table serum HCV-RNA and/or decreasing anti-HCV titres. As~ unsuitable for monitoring because they miss the disappearance J~t2tlUlll UI IIVUI kllbeasl~ rall~lllg 110 and genetic heterogeneity of HCV c ~lication of the virus do not invarial other forms of viral hepatitis are Detection of anti-HCV does not help gative patients can indicate a recent ] 7V-RNA suggests that anti-HCV can bt acute hepatitis cases HCV-RNA d tpy monitoring anti-HCV by imn response that invariably has occur Assays that detect multiple anti-HC of single antibodies. Anti-C22 ar rally it has the highest titre. Anti-Cl00 titres decrease earlier than tis who respond to antiviral therapy. The natural course of HCV ~hases: disease, asymptomatic carrier and recover'. If transition from t sists for years it may warrant in susceptible hosts severe forms of live s C virus; HCV-RNA: Anti-HCV: RIBA: Polymerase chain reactio Nevertheless, it is capable infection and disease in a con is a RNA virus that infected individuals (30-7(1% es of surviving in inresults in a worldwide prevale into cellular DNA. carriers similar to those of he ers. We review and discuss )337)-221762; Fax: (011) peculiar aspects of chronic associated disease. such a variabili liver dama enough present the significant marker valid dia ttCV-RNA undetectable appear and earliest to be detected and usuall' patients with chronic HCV hepatitis characterized by three consecutive !c very slowly or the disease phase persists
RAKE decorrelating receiver for DS-CDMA mobile radio networks (1993)

The sliding window decorrelating algorithm (SLWA) for asynchronous multiuser (MU) DS-CDMA systems was proposed and described by Wijayasuriya et al. The near-far (NF) resistance of the algorithm was established, and its performance evaluated in single path fading channels. In the Letter, a RAKE-SLWA receiver architecture is proposed for an urban mobile radio environment, which alleviates the requirement for complex power control strategies and offers large capacity improvements over the conventional receiver. A positioning strategy is also identified for decorrelating solutions in DS-CDMA mobile radio.
Multimedia history unit Sunshine Technical School (1975)

A.T.F.A.V. Committee member, Peter Hamilton's main concern in media programs at Sunshine Technical School has been with literacy. However, a media approach to a History unit was seen to have great potential. Importantly, in a school of moderate academic achievement, the media approach offered students a personal and enriching involvement with a traditional curriculum area. Media approaches to broad curriculum areas are seen as more important than studies of the media in their own right.
IDENTITY AND ENGAGEMENT IN A DIVERSE WORLD: PLURALISM AND HOLINESS IN 1 PETER (2000)

At the outset of her provocative book, published in 1991 under the title Prisoners of Men's Dreams, Suzanne Gordon raises serious questions about the women's liberation movement in America since the late 1960s. 2 She suggests that too many women today are mired in a refashioned feminism and male-defined marketplace that confuse equality with success on male terms.She writes, "Our emphasis on the value of relationships, interdependence, and collaboration sought to balance work with love, hierarchy with healing, individualism with community."Instead, she observes, feminists were wooed away from those original commitments in order to become "prisoners of men's dreams" (3).Nowadays, Gordon insists, too many women see as the goal of their liberation being "treated as a man's equal in a man's world," with the result that in this new, equal-opportunity feminism, "the ultimate goal is traditional American success-making money; relentlessly accumulating possessions; capturing and hoarding power, knowledge, access, and information; grasping and clinging to fame, status, and privilege; proving that you are good enough, smart enough, driven enough to get to the top, and tough enough to stay there" (7-8).Women, Gordon notes, "have entered the male kingdom-and yet, we have been forced to play by the king's rules" (4).To change the metaphor, we might say that transformative feminism has too often and too easily found itself genuflecting before the "Golden Rule": Whoever has the gold, makes the rules.Why do I rehearse these indictments on the feminist movement from Suzanne Gordon, herself a feminist bent on revitalizing that earlier feminist vision?It is because her assessment of the progress of feminism in the last third of the twentieth century serves as a telling parable for Christians in an increasingly diverse world, where the measures of our faithful witness are too often and too easily taken according to canons and criteria alien to Scripture and the Creed.This is a world
Characterization of<i>Neospora caninum</i>iscom antigens using monoclonal antibodies (1998)

Neospora caninum is a cyst-forming coccidian parasite which in cattle can cause abortion and birth of feeble calves. For the serological diagnosis of neosporosis, antibodies directed to the parasite can be demonstrated by ELISA, utilizing N. caninum proteins incorporated into iscoms (immunostimulating complexes) as antigen. Electrophoretic and immunoblotting studies had earlier revealed that N. caninum iscoms contained a restricted number of proteins compared with soluble parasite extracts, but the cellular origin of the incorporated proteins has not yet been determined. In the present study, monoclonal antibodies were raised against N. caninum iscoms. Six of these, named Ncmab-4, 7, 10, 13, 17 and 24, were used to characterize the N. caninum iscom antigen. The nature of the reactive epitopes and their localization within N. caninum tachyzoites were determined by means of immunological methods, including immunoblot, IFAT and immunogold electron microscopy. The apparent molecular weights of the dominant iscom antigens were found to be 18, 30, 32, 41 and 61 kDa. While the 61 kDa antigen was located intracellularly, the others were found on the parasite surface as well as within distinct intracellular compartments.
Surface Plasmon Resonance:  Theoretical Evolutionary Design Optimization for a Model Analyte Sensitive Absorbing-Layer System (2004)

Surface plasmon resonance (SPR) has been widely used in a Kretschmann configuration to study optical thickness changes of layers on a Au surface in response to an analyte. The method has been popularized and optimized for protein layers, but has also been used in the same format for other layers without further optimization including those absorbing at the incident wavelength. In this paper, we examine whether SPR remains the "best"attenuated reflectivity format for absorbing overlayers. Experimental data from the SPR response of a copper phthalocyanine film to nitrogen dioxide are used as an input example for a design process using an evolutionary algorithm. The data showed a trend toward thinner gold layer systems ( approximately 25 nm gave an contrast-enhancement of 42.9% compared with approximately 50-nm Au) or Au-free solutions including a layer with low refractive index. From the evolutionary design predictions, further modification could be tested based on available materials and "redundant layers" could be eliminated from the final selection. By inclusion of the external optics, a design could be selected to accommodate poor precision (+/-0.5 degrees ) in the incident angle and a possible multilayer solution was shown using Teflon AF 1600, with refractive index approximately 1.3. The predicted NO(2) response showed an improvement compared with the classical SPR configuration, and the incident angle chosen by the SGA for the interrogation of these layers was close to a stationary point in the absolute response curve, thus offering very good tolerance to automatic position referencing to the reflectivity minimum.
A general framework for benchmarking firewall optimization techniques (2008)

Firewalls are among the most pervasive network security mechanisms, deployed extensively from the borders of networks to end systems. The complexity of modern firewall policies has raised the computational requirements for firewall implementations, potentially limiting the throughput of networks. Administrators currently rely on ad hoc solutions to firewall optimization. To address this problem, a few automatic firewall optimization techniques have been proposed, but there has been no general approach to evaluate the optimality of these techniques. In this paper we present a general framework for rule-based firewall optimization. We give a precise formulation of firewall optimization as an integer programming problem and show that our framework produces optimal reordered rule sets that are semantically equivalent to the original rule set. Our framework considers the complex interactions among the rules in firewall configurations and relies on a novel partitioning of the packet space defined by the rules themselves. For validation, we employ this framework on real firewall rule sets for a quantitative evaluation of existing heuristic approaches. Our results indicate that the framework is general and faithfully captures performance benefits of firewall optimization heuristics.
Characterization of flaws in a tube bundle mock-up for reliability studies (1996)

As part of an assessment of in-service inspection of steam generator tubes, the authors will assemble a steam generator mock-up for round robin studies and use as a test bed in evaluating emerging technologies. Progress is reported on the characterization of flaws that will be part of the mock-up. Eddy current and ultrasonic techniques are being evaluated as a means to characterize the flaws in the mock-up tubes before final assembly. Twenty Inconel 600 tubes with laboratory-grown cracks, typical of those to be used in the mock-up, were provided by Pacific Northwest National Laboratory for laboratory testing. After the tubes were inspected with eddy current and ultrasonic techniques, they were destructively analyzed to establish the actual depths, lengths, and profiles of the cracks. The analysis of the results will allow the best techniques to be used for characterizing the flaws in the mock-up tubes.
Unsupervised learning of invariant representations with low sample complexity: the magic of sensory cortex or a new framework for machine learning? (2014)

This work was supported by the Center for Brains, Minds and Machines
(CBMM), funded by NSF STC award CCF - 1231216.
Airway Management for Trauma Patients (2018)

Trauma airway management is a critical skill for medical providers supporting combat casualties since it is an integral component of damage control resuscitation and surgery. This clinical practice guideline presents methods for optimizing the airway management of patients with traumatic injury in the operational medical treatment facility environment. The guidelines represent the knowledge and experience of 10 co-authors from 3 allied countries representing Emergency Medicine, Surgery and Anesthesia.
ChemInform Abstract: Crystal Structure and Magnetic Properties of an Octacyanometalate‐Based Three‐Dimensional Tungstate(V)—Manganese(II) Bimetallic Assembly. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A statistical methodology for drug–drug interaction surveillance (2008)

Interaction between drug substances may yield excessive risk of adverse drug reactions (ADRs) when two drugs are taken in combination. Collections of individual case safety reports (ICSRs) related to suspected ADR incidents in clinical practice have proven to be very useful in post-marketing surveillance for pairwise drug--ADR associations, but have yet to reach their full potential for drug-drug interaction surveillance. In this paper, we implement and evaluate a shrinkage observed-to-expected ratio for exploratory analysis of suspected drug-drug interaction in ICSR data, based on comparison with an additive risk model. We argue that the limited success of previously proposed methods for drug-drug interaction detection based on ICSR data may be due to an underlying assumption that the absence of interaction is equivalent to having multiplicative risk factors. We provide empirical examples of established drug-drug interaction highlighted with our proposed approach that go undetected with logistic regression. A database wide screen for suspected drug-drug interaction in the entire WHO database is carried out to demonstrate the feasibility of the proposed approach. As always in the analysis of ICSRs, the clinical validity of hypotheses raised with the proposed method must be further reviewed and evaluated by subject matter experts.
Multithreading with distributed functional units (1997)

Multithreaded processors multiplex the execution of a number of concurrent threads onto the hardware in order to hide latencies associated with memory access, synchronization, and arithmetic operations. Conventional multithreading aims to maximize throughput in a single instruction pipeline whose execution stages are served by a collection of centralized functional units. This paper examines a multithreaded microarchitecture where the heterogeneous functional unit set is expanded so that units may be distributed and partly shared across several instruction pipelines operating simultaneously, thereby allowing greater exploitation of interthread parallelism in improving utilization factors of costly resources. The multiple pipeline approach is studied specifically in the Concurro processor architecture-a machine supporting multiple thread contexts and capable of context switching asynchronously in response to dynamic data and resource availability.
Design of Sequence‐specific DNA Cleaving Molecules (1986)

The design of sequence-specific cleaving molecules for double-helical DNA requires the attachment of DNA cleaving moieties to sequence-specific DNA binding molecules. The site of attachment and choice of cleaving strategy will be dependent on the availability of molecular models for the sequence-specific binding of small molecules (i.e., 1000 MW) to right-handed double-helical DNA. Productive model building is possible because of recent progress in the development of analytical methods, such as footprinting and affinity cleaving, to determine the preferred binding locations, binding site sizes, and orientations of natural or synthetic sequence-specific DNA binding molecules on large DNA such as DNA restriction fragments (100-500 bp). \n\nThe natural product distamycin is a crescent-shaped tripeptide containing three N-methylpyrrolecarboxamides which binds in the minor groove of right-handed double-helical DNA with a strong perference for A•T rich sequences (FIG. I). The preferred sequences, binding site size, and orientation preference for tris-N-methylpyrrolecarboxamide are known from footprinting and affinity cleaving data. Moreover, from recent X-ray analysis of the complex of the dipeptide, netropsin, with the B-DNA dodecamer, S-CGCGAATTCGCG-3', Dickerson and co-workers have provided a molecular basis for the recognition of DNA by netropsin, and by extension, distamycin. They find that netropsin sits symmetrically in the center of the minor groove of A•T rich right-handed DNA and displaces the water molecules of the spine of hydration. Each of its three amide NH groups forms a bridge between adjacent adenine N3 or thymine O2 atoms on opposite helix strands." Dickerson and coworkers suggest that the base specificity of netropsin for contiguous sequences of A •T base pairs in B-DNA is provided not by hydrogen bonding but by close van der Waals contacts between adenine C2 hydrogens and CH groups on the pyrrole rings of the\noligopeptide molecules.
Structures of TGF-&#946; Receptor Complexes: Implications for Function and Therapeutic Intervention Using Ligand Traps (2011)

TGF-β isoforms (TGF-β1, -β2, and -β3) are secreted signaling ligands that stimulate the expression of protein components of the extracellular matrix, regulate the growth and differentiation of epithelial cells, modulate immune cell function, and play roles in the development of several essential organs, including the heart and lungs. The importance of the TGF-βs is underscored by their conservation among vertebrates and by their demonstrated roles in a variety of human diseases, including tissue fibrosis and cancer. The objective of this review is to highlight recent progress in characterizing the structures of the three TGF-β isoforms in complex with their receptors, and to compare these with one another as well as with other members of the superfamily. Although the structural information and accompanying biophysical studies emphasize the shared ancestry of TGF-βs, they also provide insight as to how the TGF-βs diverged from other members of the superfamily and one another to fulfill distinct roles in vivo. The similarities and differences by which the isoforms bind their receptors present unique opportunities for designing pan-isoform and isoform-specific ligand traps and progress toward developing these is described.
Testing of Metallic and Inorganic Coatings (1987)

Description Overview papers discuss various characteristics for which coatings are tested, explaining in detail what the characteristic is, what its significance is to the function of a coating, what actually is being measured, and what the ability is of the available tests to accurately measure the characteristics.
[Role of growth factors in the regulation of embryo development and implantation]. (1992)

Although it has been reported that growth factor and extracellular matrix (ECM) play an important role in the control of cell proliferation and differentiation in general, their involvement in the regulation of early embryogenesis and implantation is poorly understood. In order to clarify the mechanism underlying establishment and maintenance of pregnancy, the effect of EGF, TGF-alpha, TGF-beta, TN (tenascin) on the development of preimplantation embryo and endometrial function were investigated. 1. Growth factors in early embryogenesis. EGF did not exert any significant effect on the development of mouse 2-cell embryo in vitro. RT-PCR revealed the presence of EGFmRNA in blastocyst and 2-cell embryo, in which it may be derived from maternal genome. PA-1 cells, human teratocarcinoma-derived cell line, share biochemical characteristics with embryo developed at and beyond blastocyst stage. Anti-EGF antibody but not EGF exerted inhibitory effect on DNA synthesis in PA-1 cell, which produced and secreted immunoreactive and bioactive EGF and contained high-affinity EGF receptor. These results indicate that autocrine/paracrine mechanism of EGF action may be a key regulation of embryo development at and beyond blastocyst stage. 2. Growth factors and ECM in implantation. The luminal fluid in DES-stimulated mouse uterus contained high concentrations of EGF and TGF-alpha. In vivo administration of EGF, like estrogen, stimulated uterine epithelial proliferation as well as progesterone receptor levels. In vivo administration of anti-EGF antibody or anti-TGF-alpha antibody significantly reduced estrogen-induced labelling index in castrated mouse uterus. The concomitant administration of TGF-beta 1 and TGF-beta 2 with estrogen further stimulated DNA synthesis in the mouse uterus than estrogen alone. These results suggest that growth factors partly may be a mediator of estrogen actions on the uterine cell proliferation and the induction of progesterone receptor, which are important preparative steps for implantation. Northern blotting and in situ hybridization using cDNA probe for mouse prepro EGF revealed the presence of prepro EGFmRNA in the early pregnant mouse uterus, especially in stroma/decidua in Day 6 of pregnancy. EGF and TGF-alpha significantly stimulated trophoblast outgrowth of the mouse blastocyst in vitro in supplementation with 0.1% of fetal bovine serum. The specific binding of EGF was detected in the outgrown trophoblastic cells and inner cell mass of cultured blastocysts by autoradiography. From these findings, it may be possible that EGF produced in stromal/decidual cells exerts stimulatory effect on trophoblast outgrowth, playing an important role in the interaction between embryo and endometrium.(ABSTRACT TRUNCATED AT 400 WORDS)
Coated Textiles (2007)

Initially written to pull together scattered literature in polymer science and textile technology, the first edition of Coated Textiles: Principles and Applications became a gold standard resource in this field. Completely revised and updated, this second edition reflects not only the latest developments in the field, but also explores futur
Soluble CD44 splice variants in metastasizing human breast cancer (1997)

The local expression of CD44 splice variants in human breast cancer tissue has been previously shown to be associated with metastasis. We show here that elevated systemic serum levels of CD44 splice variants occur in breast cancer and may represent a new tool for staging and differential diagnosis. Sera of node-negative and node-positive breast cancer patients in comparison with healthy control subjects were analyzed for serum CD44 (sCD44) and 2 different splice variants (v5 and v6). Node-positive breast cancer patients showed significantly (p < 0.01) elevated levels of sCD44-v5 and -v6 splice variants in comparison to node-negative patients and healthy controls. None of the node-negative breast cancer patients or healthy controls showed elevated levels of both sCD44-v5 and -v6. Interestingly, no differences were seen for serum levels of non-spliced sCD44-standard between the 3 groups. Soluble forms of CD44 variants may promote migration of tumor cells. This may occur through interference with tumor cell adhesion or by modulation of immune defense mechanisms. Int. J. Cancer 74:443–445, 1997. © 1997 Wiley-Liss, Inc.