gebhart/patrepeval huggingface dataset:
A new design procedure for profile extrusion dies (1996)

Abstract A new design procedure for complex profile extrusion dies is presented. This method applies to multiple channel dies, i.e. dies provided with melt flow independent channels in the land. The approach is based on the resolution of the flow inverse problem, which consists of finding the channel topology (channel land lengths, approach angles in the transition region), which gives a balanced flow at the die orifice from the knowledge of the die contour. The methodology uses a blend of the network approach and the cross‐section method. The procedure is used to design an industrial die that has been tested in a manufacturing environment, showing the performance of the proposed approach.
Smooth muscle cells produce an inhibitor of endothelial cell growth. (1985)

A potent inhibitor of endothelial cell growth and neovascularization has previously been isolated from both bovine and human aorta. In an attempt to determine if the major cellular component of that tissue, smooth muscle cells, synthesized molecules with this activity, we studied the effects of serum-free conditioned medium from bovine aortic smooth muscle on the growth of cultured endothelial cells from bovine aorta. The smooth muscle conditioned medium was found to contain both growth inhibitory and stimulating activities that could be distinguished by their heat stability. The inhibitor is precipitable by ammonium sulfate, heat stable (80 degrees C), and inactivated by dithiothreitol, trypsin, and 2-mercaptoethanol. It has an estimated molecular weight of approximately 35,000 to 40,000 daltons (by column chromatography). It therefore appears that smooth muscle cells produce an inhibitor of endothelial cell growth that belongs to a class of natural endothelial cell growth inhibitors derived from avascular tissues we tentatively term "avasculins." Proof of its identity with the inhibitor isolated from intact aorta (or other tissues) must await purification.
Identification of Sequential IgE-Binding Epitopes on Bovine α<sub>s2</sub>-Casein in Cow’s Milk Allergic Patients (2002)

We identified 10 sequential IgE-binding regions on alpha(s2)-casein and performed the first crucial step in the development of immunotherapeutic interventions for CMA.
Secondary Ion Time-Of-Flight Mass Spectrometers and Data Systems (1987)

ABSTRACT Some recent improvements to the Manitoba linear time-of-flight mass spectrometer are reviewed. A new data system gives greatly improved performance. A detector assembly with a small 45° ion mirror and separate detectors for neutral and charged particles has been added. In conjunction with the new data system, it enables measurement of correlations between neutral and charged fragments resulting from unimolecular decay in the flight tube. A new time-of-flight spectrometer has been constructed. It is a reflecting instrument with a relatively long ion mirror. Resolution and signal/background ratio are much better than in the linear instrument, and correlation measurements can be made with considerably higher accuracy in mass determination than with the small mirror.
Slow port scanning detection (2011)

Port scanning is the most popular reconnaissance technique attackers use to discover services they can break into. Port scanning detection has received a lot of attention by researchers. However a slow port scan attack can deceive most of the existing Intrusion Detection Systems (IDS). In this paper, we present a new, simple, and efficient method for detecting slow port scans. Our proposed method is mainly composed of two phases: (1) a feature collection phase that analyzes network traffic and extracts the features needed to classify a certain IP as malicious or not. (2) A classification phase that divides the IPs, based on the collected features, into three groups: normal IPs, suspicious IPs and scanner IPs. The IPs our approach classify as suspicious are kept for the next (K) time windows for further examination to decide whether they represent scanners or legitimate users. Hence, this approach is different than the traditional approach used by IDSs that classifies IPs as either legitimate or scanners, and thus producing a high number of false positives and false negatives. A small Local Area Network was put together to test our proposed method. The experiments show the effectiveness of our proposed method in correctly identifying malicious scanners when both normal and slow port scan were performed using the three most common TCP port scanning techniques. Moreover, our method detects malicious scanners that are otherwise not detected using well known IDSs such as Snort.
Multicomponent distributed acoustic sensing (2016)

Distributed Acoustic Sensing (DAS) data in boreholes are not commonly used for reservoir characterization because multicomponent data are needed to quantify different wave modes. We propose two approaches to obtain multicomponent DAS data by using either multiple parallel optical fibers or a helical optical fiber. The multiple parallel optical fibers use the shape sensing method which is based on measurements of axial strain gradient to obtain the curvature of the cable and then reconstruct the components of the displacement field. However, simply using curvature measurements does not provide sufficient information to reconstruct the displacements for different wave modes. The helical optical fiber uses the characteristics of the helix shape to obtain angle dependent strain measurements, which provides sufficient information to reconstruct the strain tensor of the surrounding field. Presentation Date: Monday, October 17, 2016 Start Time: 1:00:00 PM Location: Lobby D/C Presentation Type: POSTER
Exosomes Isolated from Mycobacteria-Infected Mice or Cultured Macrophages Can Recruit and Activate Immune Cells In Vitro and In Vivo (2012)

More than 2 billion people are infected with Mycobacterium. tuberculosis; however, only 5-10% of those infected will develop active disease. Recent data suggest that containment is controlled locally at the level of the granuloma and that granuloma architecture may differ even within a single infected individual. Formation of a granuloma likely requires exposure to mycobacterial components released from infected macrophages, but the mechanism of their release is still unclear. We hypothesize that exosomes, which are small membrane vesicles containing mycobacterial components released from infected macrophages, could promote cellular recruitment during granuloma formation. In support of this hypothesis, we found that C57BL/6 mouse-derived bone marrow macrophages treated with exosomes released from M. tuberculosis-infected RAW264.7 cells secrete significant levels of chemokines and can induce migration of CFSE-labeled macrophages and splenocytes. Exosomes isolated from the serum of M. bovis bacillus Calmette-Guérin-infected mice could also stimulate macrophage production of chemokines and cytokines ex vivo, but the level and type differed during the course of a 60-d infection. Of interest, the exosome concentration in serum correlated strongly with mouse bacterial load, suggesting some role in immune regulation. Finally, hollow fiber-based experiments indicated that macrophages treated with exosomes released from M. tuberculosis-infected cells could promote macrophage recruitment in vivo. Exosomes injected intranasally could also recruit CD11b(+) cells into the lung. Overall, our study suggests that exosomes may play an important role in recruiting and regulating host cells during an M. tuberculosis infection.
Nitrile oxides. IX. Basic substituted stable nitrile oxides (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrile oxides. IX. Basic substituted stable nitrile oxidesChristoph Grundmann and Reinhard RichterCite this: J. Org. Chem. 1967, 32, 7, 2308–2312Publication Date (Print):July 1, 1967Publication History Published online1 May 2002Published inissue 1 July 1967https://pubs.acs.org/doi/10.1021/jo01282a047https://doi.org/10.1021/jo01282a047research-articleACS PublicationsRequest reuse permissionsArticle Views381Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Targeted transendocardial therapeutic delivery guided by mri—x‐ray image fusion (2011)

Multi-modality image fusion is a feasible and accurate platform technology to guide transendocardial injections precisely to the discrete infarct border.
Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T- cell leukemia/lymphoma (1995)

The protein p27KIP1 belongs to a recently identified family of proteins termed cyclin-dependent kinase inhibitors (CDKIs). These proteins play an important role in regulating cell-cycle progression and loss of their function has been implicated in tumorigenesis. Transforming growth factor beta (TGF-beta) may induce cell growth arrest through p27 activation. TGF-beta often loses its ability to arrest growth of transformed cells; this could potentially occur through a defect in p27. To determine the role of p27 in tumorigenesis, we examined its mutational status in 74 non-Hodgkin's lymphomas (NHLs) (52 of B-cell phenotype, 22 of T-cell phenotype), 5 lymphoma cell lines, and 42 adult T-cell leukemias/lymphomas (ATLs) using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and Southern blot analyses. A nonsense mutation (stop codon) that could result in expression of a truncated nonfunctional p27 protein was detected at codon 76 in one case of acute lymphomatous ATL, but not in matched normal tissues. Previously undescribed polymorphisms were also identified at codon 109 in the lymphomas and at codon 55 in the ATLs. Two homozygous deletions of the p27 gene were detected in one case of B-immunoblastic NHL and in one case of acute ATL by Southern blot hybridization. These results indicate that p27 gene alterations are rare events in NHLs and ATLs, but may play an important role in the pathogenesis of some hematologic malignancies.
Standard Handbook of Lubrication Engineering (1969)

Standard handbook of lubrication engineering , Standard handbook of lubrication engineering , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Hypothesis: in vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus. (1983)

It is often considered that the inflammatory processes in the rheumatoid synovium are due to an immune response to an as yet unknown antigen; the resultant pannus has been referred to as "aggressive, invasive, proliferative and tumor-like." Data are presented which show that arthritogenic group A streptococcal cell walls stimulate human monocyte-macrophages to elevate the plasminogen activator (PA) activity of human synoviocytes. By analogy with other cellular systems, it is suggested that the monocyte-macrophage mediated elevation of synoviocyte PA activity can contribute to the tissue remodelling and cell migration found in the rheumatoid pannus. It is also proposed that the active moiety from the stimulated monocyte-macrophages is able to mimic, to some extent, the effects of transforming viruses and tumor promoters on cell function. This concept of a "tumor-like" synoviocyte transformation is suggested as being consistent with the descriptions of the rheumatoid pannus as "aggressive, invasive and tumor-like." Perhaps similar cellular interactions occur in other inflammatory diseases involving connective tissue turnover and cellular hyperplasia.
Practical static analysis of JavaScript applications in the presence of frameworks and libraries (2013)

JavaScript is a language that is widely-used for both web- based and standalone applications such as those in the upcoming Windows 8 operating system. Analysis of JavaScript has long been known to be challenging due to its dynamic nature. On top of that, most JavaScript applications rely on large and complex libraries and frameworks, often written in a combination of JavaScript and native code such as C and C++. Stubs have been commonly employed as a partial specification mechanism to address the library problem; however, they are tedious to write, incomplete, and occasionally incorrect.
Total joint arthroplasty. The hand. (1979)

Joint replacement in the hand has developed on the basis of improved understanding of the pathophysiologic and the biomechanical factors involved in normal and diseased joints. Compromises are required in prosthetic design and surgical reconstruction, but function and appearance in deformed hands are susceptible to surgical improvement.
The Putative Bioactive Surface of Insect-selective Scorpion Excitatory Neurotoxins (1999)

Scorpion neurotoxins of the excitatory group show total specificity for insects and serve as invaluable probes for insect sodium channels. However, despite their significance and potential for application in insect-pest control, the structural basis for their bioactivity is still unknown. We isolated, characterized, and expressed an atypically long excitatory toxin, Bj-xtrIT, whose bioactive features resembled those of classical excitatory toxins, despite only 49% sequence identity. With the objective of clarifying the toxic site of this unique pharmacological group, Bj-xtrIT was employed in a genetic approach using point mutagenesis and biological and structural assays of the mutant products. A primary target for modification was the structurally unique C-terminal region. Sequential deletions of C-terminal residues suggested an inevitable significance of Ile73 and Ile74 for toxicity. Based on the bioactive role of the C-terminal region and a comparison of Bj-xtrIT with a Bj-xtrIT-based model of a classical excitatory toxin, AaHIT, a conserved surface comprising the C terminus is suggested to form the site of recognition with the sodium channel receptor.
Lifting-based wavelet domain adaptive Wiener filter for image enhancement (2006)

A method of applying lifting-based wavelet domain Wiener filter (LBWDMF) in image enhancement is proposed. Lifting schemes have emerged as a powerful method for implementing biorthogonal wavelet filters. They exploit the similarity of the filter coefficients between the low-pass and high-pass filters to provide a higher speed of execution, compared to classical wavelet transforms. LBWDMF not only helps in reducing the number of computations but also achieves lossy to lossless performance with finite precision. The proposed method utilises the multi-scale characteristics of the wavelet transform and the local statistics of each subband. The proposed method transforms an image into the wavelet domain using lifting-based wavelet filters and then applies a Wiener filter in the wavelet domain and finally transforms the result into the spatial domain. When the peak signal-to-noise ratio (PSNR) is low, transforming an image to the lifting-based wavelet domain and applying the Wiener filter in the wavelet domain produces better results than directly applying Wiener filter in spatial domain. In other words each subband is processed independently in the wavelet domain by a Wiener filter. Moreover, in order to validate the effectiveness of the proposed method the result obtained using the proposed method is compared to those using the spatial domain Wiener filter (SDWF) and classical wavelet domain Wiener filter (CWDWF). Experimental results show that the proposed method has better performance over SDWF and CWDWF both visually and in terms of PSNR.
Sensitive far uv spectrograph with a multispectral element microchannel plate detector for rocket-borne astronomy (1976)

An evacuated high transmission prism spectrograph using a microchannel plate detection system with resistive strip readout was flown behind a precision pointing telescope on a sounding rocket. The construction, preparation, flight performance, and calibration stability of the system are discussed. Despite the adverse environmental conditions associated with sounding rocket flights, the microchannel detector system performed well. Far uv spectra (1160-1750 A) of stellar and planetary objects were obtained; spectral features with fluxes as low as 0.06 photons cm(-2) sec(-1) were detectable. This was achieved by operating the plates at lower than normal gains, using sensitive pulse counting electronics with both upper and lower limit discriminators, and maintaining the spectrograph and detector at a pressure of ~10(-6) Torr until reaching altitude.
Viscoelasticity of Crosslinked Fracturing Fluids and Proppant Transport (1987)

ABSTRACT In hydraulic fracturing treatments, the success of the treatment strongly depends on the proper placement of the proppant particles in the fracture. By proper placement, one means the packing of the fracture to achieve maximum conductivity of gas/oil through the fracture into the wellbore. The placement of the proppants along the fracture is based on design equations where sand transport velocity is related to the rheological parameters of the fracturing fluid and characteristics of the proppant particle such as size and density. The current design equations consider viscous parameters such as K' and n' of power-law model. In practice, however, there are numerous cross-linked fracturing fluids which are not just viscous, but visco-elastic in nature. At present, there are no design equations for proppant transport that can be incorporated into a hydraulic fracturing program which takes into account linear and non-linear viscoelasticity of cross-linked fluids. The purpose of this paper is three fold. The first part of the paper describes the theoretical transport equations that take into account the elasticity of the fluid in predicting proppant settling rate in the fracture. The second part of the paper presents the experimental data of commonly used fracturing fluids (titanate and borate cross-linked). The rheology data includes both viscous and elastic parameter measurements using Rheometrics Pressure Rheometer and Rheometrics Mechanical Spectrometer. This data shows some important differences between borate cross-linked gels and titanate cross-linked gels. The third part of the paper presents experimental data of proppant settling rates in various fracturing fluids and how these can be correlated with rheological parameters that were obtained in this work. The difference in rheology between borate and titanate gels was correlated with the difference in settling rates of proppants in these two gels. Based on the theoretical and experimental work presented in this paper, it is concluded that the model for proppant placement in a hydraulic fracture should include: (i) proppant characteristics, (ii) viscous rheological parameters (K' and n'), (iii) elastic parameters (complex dynamic viscosity) from linear viscoelastic constitutive equation, and (iv) normal stress difference from non-linear viscoelastic constitutive equation. The influence of cross-linked polymer gel network structure on proppant transport is also discussed.
Equalization for maximum likelihood detectors (1995)

In this paper, the minimum mean-square error (MMSE) technique has been used to equalize the recording channel in order to facilitate the application of the Viterbi detector. The resulting performance has been compared with that of the optimal equalization system which yields the minimum probability of error at the output of the Viterbi detector. The results indicate that depending on the constraint used in the MMSE design, the amount of noise correlation varies significantly at the equalizer output, which in turn makes a large difference in the performance of the Viterbi detector. In particular, in the jitter-dominant channel where unconditioned channel noise samples are highly correlated, the monic constraint on the equalizer target response tends to whiten the noise samples at the equalizer output. This results in a significant performance improvement of the monic constraint upon the fixed-energy constraint as well as the popular partial response targets of the form (1-D)(1+D)/sup n/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Coupled Generative Adversarial Networks (2016)

We propose coupled generative adversarial network (CoGAN) for learning a joint distribution of multi-domain images. In contrast to the existing approaches, which require tuples of corresponding images in different domains in the training set, CoGAN can learn a joint distribution without any tuple of corresponding images. It can learn a joint distribution with just samples drawn from the marginal distributions. This is achieved by enforcing a weight-sharing constraint that limits the network capacity and favors a joint distribution solution over a product of marginal distributions one. We apply CoGAN to several joint distribution learning tasks, including learning a joint distribution of color and depth images, and learning a joint distribution of face images with different attributes. For each task it successfully learns the joint distribution without any tuple of corresponding images. We also demonstrate its applications to domain adaptation and image transformation.
Ruxolitinib for Severe COVID-19-Related Hyperinflammation in Nonresponders to Steroids (2021)

In this study, ruxolitinib resolved hyperinflammatory state in 55% of the patients, regardless of the previous steroid or tocilizumab therapy. Unfortunately, few patients demonstrated severe evolution despite ruxolitinib therapy. Notably, the treatment starting time appears to play an important role in achieving good outcomes. Further validation in randomized controlled trials is crucial.
Robust minimum statistics project coefficients feature for acoustic environment recognition (2014)

Acoustic environment recognition has been widely used in many applications, and is a considerable difficult problem for the real-life and complex environment. This paper proposes a novel feature, named minimum statistics project coefficients (MSPC), and intents to solve this problem. The MSPC feature is extracted from the background sound which is more robust than the foreground sound for the task of acoustic environment recognition. Experimental results show the outstanding performance of the MSPC feature compared with the conventional acoustic features, especially in very complex acoustic environments.
Matrix completion from a few entries (2009)

Let M be an n¿ × n matrix of rank r ¿ n, and assume that a uniformly random subset E of its entries is observed. We describe an efficient algorithm that reconstructs M from |E| = O(r n) observed entries with relative root mean square error RMSE ¿ C(¿) (nr/|E|) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> . Further, if r = O(1) and M is sufficiently unstructured, then it can be reconstructed exactly from |E| = O(n log n) entries. This settles (in the case of bounded rank) a question left open by Candes and Recht and improves over the guarantees for their reconstruction algorithm. The complexity of our algorithm is O(|E|r log n), which opens the way to its use for massive data sets. In the process of proving these statements, we obtain a generalization of a celebrated result by Friedman-Kahn-Szemeredi and Feige-Ofek on the spectrum of sparse random matrices.