gebhart/patrepeval huggingface dataset:
Improvement in the heterogeneous N‐termini and the defective <i>N</i>‐glycosylation of human interleukin‐6 by genetic engineering (1992)

Recombinant human interleukin-6 (IL-6), expressed in Chinese hamster ovary cells, has heterogeneous N-termini of Ala1 and Val3, as does naturally occurring IL-6. This heterogeneity is thought to be caused by difficulty in cleavage of the signal sequence. To obtain homogeneous IL-6, Pro at -1 was exchanged for Ala by site-directed mutagenesis. Alternatively, the signal sequence was replaced with that of human granulocyte-colony-stimulating factor. In both cases, the IL-6 designed to start with Ala1 was still heterogeneous, while the IL-6 designed to start with Val3 showed a homogeneous N-terminus. It is suggested that the heterogeneity of the N-terminus is caused not only by the signal sequence, but also by the succeeding sequences of the mature protein. Only a portion of recombinant human IL-6 is N-glycosylated. Asn46, being exchanged for Gln by site-directed mutagenesis, was confirmed to be partially N-glycosylated. The defective N-glycosylation was assumed to be caused by interference or tension from a disulfide bond near the N-glycosylation site. To verify this hypothesis, the Cys45 and Cys51 forming the disulfide bond were exchanged for Ser. The N-glycosylated species became predominant upon this substitution, suggesting that formation of the disulfide bond is a cause of the defective N-glycosylation.
Media Deregulation and the Development of China's Radio Industry (2005)

In China, radio used to be a tool for publicising government policy and educating people, but since 1978 a blend of commercial and governmental radio has started to emerge. This paper will review different stages China's radio industry has undergone since 1978, from the boom of the 1980s and the decline in the 1990s to the revival in the new century. This paper holds that the main cause of the development is the gradual deregulation of the media policy. To conclude, the paper predicts the future trend of the industry, based on an analysis of present media policy in China.
Lineage retrieval for scientific data processing: a survey (2005)

Scientific research relies as much on the dissemination and exchange of data sets as on the publication of conclusions. Accurately tracking the lineage (origin and subsequent processing history) of scientific data sets is thus imperative for the complete documentation of scientific work. Researchers are effectively prevented from determining, preserving, or providing the lineage of the computational data products they use and create, however, because of the lack of a definitive model for lineage retrieval and a poor fit between current data management tools and scientific software. Based on a comprehensive survey of lineage research and previous prototypes, we present a metamodel to help identify and assess the basic components of systems that provide lineage retrieval for scientific data products.
A comprehensive surface mount reliability model covering several generations of packaging and assembly technology (1993)

An extensive set of surface mount reliability data gathered between 1984 and 1992 has been integrated in a single design-for-reliability tool, the comprehensive surface mount reliability (CSMR) model. This analytical/empirical model fits 28 accelerated test datasets with a correlation coefficient of 0.97, a significant improvement over a correlation of 0.40 over the same database for the existing figures of merit. The new solder joint life prediction capability spans test conditions with a wide range of frequencies and temperature limits and covers three orders of magnitude in cyclic life. The validity of the model has been verified for evolving families of components, substrates and assembly technology, including 0.5-mm pitch Alloy 42 thin small-outline packages (TSOPs) and large, 25-mil pitch devices. The innovative features of the CSMR methodology are presented, and its application is is illustrated for several design examples. Important benefits of the model are more accurate surface mount (SM) reliability predictions and less conservative design decisions than from previous models.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pre-computed Liquid Spaces with Generative Neural Networks and Optical Flow (2017)

We propose a novel approach for deformation-aware neural networks that learn the weighting and synthesis of dense volumetric deformation fields. Our method specifically targets the space-time representation of physical surfaces from liquid simulations. Liquids exhibit highly complex, non-linear behavior under changing simulation conditions such as different initial conditions. Our algorithm captures these complex phenomena in two stages: a first neural network computes a weighting function for a set of pre-computed deformations, while a second network directly generates a deformation field for refining the surface. Key for successful training runs in this setting is a suitable loss function that encodes the effect of the deformations, and a robust calculation of the corresponding gradients. To demonstrate the effectiveness of our approach, we showcase our method with several complex examples of flowing liquids with topology changes. Our representation makes it possible to rapidly generate the desired implicit surfaces. We have implemented a mobile application to demonstrate that real-time interactions with complex liquid effects are possible with our approach.
Peer-to-Peer Applications in Ad Hoc Wireless Networks (2002)

With the rapid development of wireless technology, more and more people are equipped with mobile devices, which allow them to communicate and share resources each other. The combination of mobility and wireless networking makes the emergence of mobile computing paradigm that gives more flexibility and opportunities to people.
The Prostate Health Index: a new test for the detection of prostate cancer (2013)

A major focus in urologic research is the identification of new biomarkers with improved specificity for clinically-significant prostate cancer. A promising new test based on prostate-specific antigen (PSA) is called the Prostate Health Index (PHI), which has recently been approved in the United States, Europe and Australia. PHI is a mathematical formula that combines total PSA, free PSA and [-2] proPSA. Numerous international studies have consistently shown that PHI outperforms its individual components for the prediction of overall and high-grade prostate cancer on biopsy. PHI also predicts the likelihood of progression during active surveillance, providing another noninvasive modality to potentially select and monitor this patient population. This article reviews the evidence on this new blood test with significant promise for both prostate cancer screening and treatment decision-making.
Testing of Doppler tolerant range sidelobe suppression in pulse compression meteorological radar (2002)

In radar meteorology, a technique has been devised for alleviating the Doppler sensitivity of sidelobe suppression so that the spectral moments of echoes from each range bin can be obtained with acceptably small flooding from neighboring range bins. The technique has been analyzed, but no pulse compression data from meteorological radar are available. The data available consist of zero-th, first, and second moments of radar echoes, from simple pulse radars. These data are used to produce simulated radar echoes from dispersed transmitted pulses by creating an appropriate complex envelope Gaussian process in each range bin. The effect of a dispersed pulse is obtained by properly combining the random processes over the appropriate number of range bins. The testbed so created can be used for a variety of signal processing techniques in radar meteorology. Using moment data supplied by the National Center for Atmospheric Research (NCAR), the radar echoes from dispersed pulses are simulated, and the authors' Doppler tolerant sidelobe technique is tested.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Sur l'alexie d'évolution familiale et héréditaire (1938)

info:eu-repo/semantics/published
Assessment and characterization of hemopoietic stem cells (1995)

The adequate production of blood cells is sustained by pluripotent hemopoietic progenitors whose behavior is influenced by a permissive hemopoietic microenvironment. Hemopoietic progenitors have in common the expression of CD34 surface molecules, but are heterogeneous with respect to other properties. It is commonly accepted that primitive progenitors, considered to be candidates for marrow repopulating cells, are HLA-DR-, without expressing lineage-specific determinants. They are usually quiescent with respect to their cell cycle status. In addition to CD34, they may display adhesion molecules on their surface and express receptors for ligands such as c-kit, FLT2/FLK3 and various other cytokines. Some of these are expressed constitutively, while others emerge as the cells progress through their regular maturation program. This process appears to include a gradual reduction of their proliferative capabilities as demonstrated by a progressive loss of the length of their telomeric structures.
Notes and references on early automatic classification work (1991)

This informal note was prompted by discussions and questions at the 1990 AAAI Spring Symposium on Text-Based Intelligent Systems (cf Jacobs 1990). There is a growing interest in access to, and the use of, large scale full-text databases for a variety of purposes, and in the application of classification methods to organise the mass of data involved (see e.g. Church and Hanks 1990). A good deal of work has been done in this field in the past, but it is little known, and some of the early research literature is not very accessible. Classification is an area in which it is easy to make plausible but mistaken assumptions, and as this certainly holds for classification in retrieval, there is a good deal that can be usefully learnt from past experience, most of which was hard won from careful thought and grinding experiment. This paper is intended as an introduction to this initial work on automatic classification, to help those now becoming interested in classification to avoid unnecessarily repeating heavy effort or, more especially, reinventing square wheels. It should also be noted that automatic classification and related (e.g. seriation) methods have been extensively developed for biological applications in particular, but have been more variously applied, and that much of this work may be relevant in the broad area of machine learning.It must be emphasised that as this paper is focussed on early work on automatic classification, particularly for information retrieval, and is designed primarily to lead into this research and its literature, it does not attempt a critical evaluation of the overall results established by now, or of the current state of the art. However it should be pointed out that in the retrieval context in general, as opposed to the wider one of classification as a whole, there has been comparatively little work since the seventies, largely for the reasons indicated in the paper. More recent work in any case refers heavily to earlier research, so this note can be taken as an entry point to the research of the last decade for which some references are given at the end of the note.
Effects of the Synthetic Neurosteroid (2015)

Taken together, these data strongly suggest a potent antidepressant-like effect of 3β-methoxypregnenolone on translational parameters.
The Texas Implementation of Medication Algorithms (2005)

These algorithms for the treatment of BDI represent the recommendations based on the most recent evidence available. These recommendations are meant to provide a framework for clinical decision making, not to replace clinical judgment. As with any algorithm, treatment practices will evolve beyond the recommendations of this consensus conference as new evidence and additional medications become available.
Clinical and molecular characterization of females affected by <scp>X</scp>‐linked retinoschisis (2015)

Clinical and genetic characterization of affected homozygous females in XLRS affords the rare opportunity to explore the molecular mechanisms of XLRS and the manifestation of these mutations as disease in humans.
New considerations in the pathogenesis of coagulase-negative staphylococcal foreign body infections (1988)

Coagulase-negative staphylococci are the predominant cause of foreign body infections. The pathogenesis is related to the ability of these staphylococci to adhere to and grow on polymer surfaces and to produce an extracellular slime substance. The exact chemical nature of this extracellular slime substance is still not known, although there is some evidence that it may be a complex glycoconjugate. On the basis of in-vitro and animal data, the extracellular slime substance seems to interfere with various host-protective mechanisms and with the action of antistaphylococcal antibiotics. These factors can explain several clinical characteristics of coagulase-negative staphylococcal foreign body infections.
Rapid condensation procedure for determination of hydroxyl in silicone materials (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid condensation procedure for determination of hydroxyl in silicone materialsRobert Carl. Smith and Gene E. KellumCite this: Anal. Chem. 1967, 39, 3, 338–340Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://pubs.acs.org/doi/10.1021/ac60247a044https://doi.org/10.1021/ac60247a044research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-Sensitivity Procalcitonin (hs-PCT): A Marker for Identification of Arteriosclerosis and Myocardial Infarction? (2008)

BackgroundProcalcitonin (PCT) is a protein hormone induced by bacterial inflammation that serves as a marker of sepsis. C-reactive protein (CRP) is also known to be a marker of inflammation and, in low concentrations, a prognostic marker for latent or early arteriosclerosis. Arteriosclerosis is considered as an inflammatory process that begins in the wall of an artery. In addition to CRP, the concentration of other markers of inflammation increases in the presence of arteriosclerosis.
Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1 (2013)

Toxoplasma gondii is an important food and waterborne pathogen that causes severe disease in immunocompromised patients. Bumped kinase inhibitors (BKIs) have an antiparasitic effect on T. gondii tachyzoite growth by targeting T. gondii calmodulin-domain protein kinase 1 (TgCDPK1). To identify mutations that confer resistance to BKIs, chemical mutagenesis was performed, followed by selection in media containing either 250 or 1000 nM 1NM-PP1. Whole-genome sequence analysis of resistant clones revealed single nucleotide mutations in T. gondii mitogen-activated protein kinase 1 (TgMAPK1) at amino acids 162 (L162Q) and 171 (I171N). Plasmid constructs having the TgMAPK1 L162Q mutant sequence successfully replaced native TgMAPK1 genome locus in the presence of 1000 nM 1NM-PP1. The inhibitory effect of 1NM-PP1 on cell division observed in the parent clone was decreased in 1NM-PP1-resistant clones; however, effects on parasite invasion and calcium-induced egress were similar in both parent and resistant clones. A plasmid construct expressing the full length TgMAPK1 splicing isoform with L162Q mutation successfully complemented TgMAPK1 function in the pressure of 250 nM 1NM-PP1 in plaque assay. 1NM-PP1-resistant clones showed resistance to other BKIs (3MB-PP1 and 3BrB-PP1) with different levels. Here we identify TgMAPK1 as a novel target for 1NM-PP1 activity. This inhibitory effect is mediated through inhibition of tachyzoite cell division, and can be overcome through mutations at multiple residues in TgMAPK1.
Aortic function quantified: the heart's essential cushion (2012)

Arterial compliance is mainly determined by the elasticity of proximal large-conduit arteries of which the aorta is the largest contributor. Compliance forms an important part of the cardiac load and plays a role in organ (especially coronary) perfusion. To follow local changes in aortic compliance, as in aging, noninvasive determination of compliance distribution would be of great value. Our goal is to determine regional aortic compliance noninvasively in the human. In seven healthy individuals at six locations, aortic blood flow and systolic/diastolic area (ΔA) was measured with MRI. Simultaneously brachial pulse pressure (ΔP) was measured with standard cuff. With a transfer function we derived ΔP at the same aortic locations as the MRI measurements. Regional aortic compliance was calculated with two approaches, the pulse pressure method, and local area compliance (ΔA/ΔP) times segment length, called area compliance method. For comparison, pulse wave velocity (PWV) from local flows at two locations was determined, and compliance was derived from PWV. Both approaches show that compliance is largest in the proximal aorta and decreases toward the distal aorta. Similar results were found with PWV-derived compliance. Of total arterial compliance, ascending to distal arch (segments 1-3) contributes 40% (of which 15% is in head and arms), descending aorta (segments 4 and 5) 25%, and "hip, pelvic and leg arteries" 20%. Pulse pressure method includes compliance of side branches and is therefore larger than the area compliance method. Regional aortic compliance can be obtained noninvasively. Therefore, this technique allows following changes in local compliance with age and cardiovascular diseases.
Appendix: New Commercial Lasers (1988)

During the past year, technical progress led to significant growth in the performance levels of several types of commercial lasers. In addition, virtually all segments of the laser industry recorded at least some improvements in the technology and in its applications. For the near term, laser-industry sources indicate continued rapid product development. Highlights of 1987 activities and examples of planned 1988 product launches make up the discussion that follows.
Introduction of the exopolysaccharide gene cluster from <i>Streptococcus thermophilus</i> Sfi6 into <i>Lactococcus lactis</i> MG1363: production and characterization of an altered polysaccharide (1999)

Streptococcus thermophilus Sfi6 produces an exopolysaccharide (EPS) composed of glucose, galactose and N-acetylgalactosamine in the molar ratio of 1:2:1. The genes responsible for the EPS biosynthesis have been isolated previously and found to be clustered in a 14.5 kb region encoding 13 genes. Transfer of this gene cluster into a non-EPS-producing heterologous host, Lactococcus lactis MG1363, yielded an EPS with a similar high molecular weight, but a different structure from the EPS from the native host. The structure of the recombinant EPS was determined by means of 1H homonuclear and 1H-13C heteronuclear two-dimensional nuclear magnetic resonance (NMR) spectra and was found to be --> 3)-beta-D-Glcp-(1 --> 3)-alpha-D-Galp-(1 --> 3)-beta-D-Galp-(1 --> as opposed to --> 3)[alpha-D-Galp-(1 --> 6)]-beta-D-Glcp-(1 --> 3)-alpha-D-GalpNAc-(1 --> 3)-beta-D-Galp-(1 --> for the wild-type S. thermophilus Sfi6. Furthermore, L. lactis MG1363 (pFS101) was also lacking a UDP-N-acetylglucosamine C4-epimerase activity, which would provide UDP-GalNAc for a GalNAc incorporation into the EPS and probably caused the substitution of GalNAc by Gal in the recombinant EPS. This modification implies that (i) bacterial glycosyltransferases could potentially have multiple specificities for the donor and the acceptor sugar molecule; and (ii) the repeating unit polymerase can recognize and polymerize a repeating unit that differs in the backbone as well as in the side-chain from its native substrate.
Automatic refresh dynamic memory (1976)

This paper will discuss an Automatic Refresh Random Access Memory (RAM) cell, derived from a single transistor cell with a modest increase in cell complexity and size.
Growth of YBCO films on MgO-based rolling-assisted biaxially textured substrates templates (2004)

We have developed a simple alternative buffer layer architecture for the rolling-assisted biaxially textured substrates (RABiTS) approach. Buffer layers with both oxygen and metal diffusion barrier properties are of interest. Cube textured magnesium oxide MgO buffers were grown directly on biaxially textured Ni and Ni–W3 at.% substrates using electron beam evaporation. We have also grown epitaxial MgO layers on 2 m long textured Ni–W3 at.% tapes in a reel-to-reel e-beam evaporation. Highly textured LaMnO3 (LMO) buffers were grown on MgO-buffered Ni substrates using rf sputtering. MgO and LMO buffers have been proved to be good oxygen diffusion barriers and Ni diffusion barriers, respectively. YBCO films with a Jc of 1 × 106 A cm−2 at 77 K and self-field were grown on this newly developed architecture of LMO/MgO/Ni using pulsed laser deposition.
Robust carrier recovery for DVB-S2 system (2011)

This paper suggests the practical approach to mitigate phase noise by using joint detection and decoding scheme for DVB-S2 system. The proposed scheme illustrates in detail to implement robust DVB-S2 receiver compared to the previous study and shows the satisfactory performance when the specific LDPC decoding schedules have been utilized in the hardware implementation point of view.
Boundary-Scan Test Standard\;——from 1149.1 to 1149.6 (2005)

In this paper, Boundary-scan Test Standards IEEE Std 1149.1 to 1149.6 are introduced. It focuses on architecture and characteristic of instruction. After analysis of the new development of boundary-scan techniques, the future direction of boundary-scan techniques is expected.
A real-time implementation of the improved MBE speech coder (2002)

A real-time, single digital signal processing (DSP) chip implementation of a 2.4-, 4.8-, and 8.0-kb/s improved multiband excitation (IMBE) vocoder is presented. The IMBE vocoder is based on the MBE speech model, and it is shown to generate high-quality speech under both clean and noisy conditions. In addition, the IMBE vocoder is well suited for real-time implementation since it does not require excessive computation or storage. Full-duplex operation is demonstrated using a single AT&T WE DSP 32. Aspects of the hardware architecture, algorithm implementation, and system performance are addressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>