gebhart/patrepeval huggingface dataset:
Sterically hindered free radicals. 18. Stabilization of free radicals by substituents as studied by using triphenylmethyls (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSterically hindered free radicals. 18. Stabilization of free radicals by substituents as studied by using triphenylmethylsWilhelm P. Neumann, Alicia Penenory, Ulrich Stewen, and Manfred LehnigCite this: J. Am. Chem. Soc. 1989, 111, 15, 5845–5851Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ja00197a053https://doi.org/10.1021/ja00197a053research-articleACS PublicationsRequest reuse permissionsArticle Views765Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Alterations of Coagulation and Fibrinolytic and Kallikrein-Kinin Systems in the Acute and Postacute Phases in Patients With Unstable Angina Pectoris (1995)

Our data indicate that in patients with unstable angina pectoris, intracoronary thrombus formation is associated with a hypercoagulative state, including activation of the contact phase and of the kallikrein system and increased bradykinin generation. The persistence of this hypercoagulative state, together with a disturbed fibrinolysis, might indicate an increased risk for further coronary events.
Sequencing in Conversational Openings<sup>1</sup> (1968)

An attempt is made to ascertain rules for the sequencing of a limited part of natural conversation and to determine some properties and empirical consequences of the operation of those rules. Two formulations of conversational openings are suggested and the properties “nonterminality” and “conditional relevance” are developed to explicate the operation of one of them and to suggest some of its interactional consequences. Some discussion is offered of the fit between the sequencing structure and the tasks of conversational openings.
Advances in Chimeric Antigen Receptor T‐Cell Therapies for Solid Tumors (2018)

In 2017, the US Food and Drug Administration approved the first two novel cellular immunotherapies using synthetic, engineered receptors known as chimeric antigen receptors (CARs), tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta), expressed by patient-derived T cells for the treatment of hematological malignancies expressing the B-cell surface antigen CD19 in both pediatric and adult patients. This approval marked a major milestone in the use of antigen-directed "living drugs" for the treatment of relapsed or refractory blood cancers, and with these two approvals, there is increased impetus to expand not only the target antigens but also the tumor types that can be targeted. This state-of-the-art review will focus on the challenges, advances, and novel approaches being used to implement CAR T-cell immunotherapy for the treatment of solid tumors.
3D magic lenses (1996)

Article 3D magic lenses Share on Authors: John Viega User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VA User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VAView Profile , Matthew J. Conway User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VA User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VAView Profile , George Williams User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VA User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VAView Profile , Randy Pausch User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VA User Interface Group, Department of Computer Science, University of Virginia, Thornton Hall, Charlottesville, VAView Profile Authors Info & Claims UIST '96: Proceedings of the 9th annual ACM symposium on User interface software and technologyNovember 1996 Pages 51–58https://doi.org/10.1145/237091.237098Online:01 November 1996Publication History 131citation1,529DownloadsMetricsTotal Citations131Total Downloads1,529Last 12 Months59Last 6 weeks8 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort (2016)

Rational flux design in metabolic engineering approaches remains difficult since important pathway information is frequently not available. Therefore empirical methods are applied that randomly change absolute and relative pathway enzyme levels and subsequently screen for variants with improved performance. However, screening is often limited on the analytical side, generating a strong incentive to construct small but smart libraries. Here we introduce RedLibs (Reduced Libraries), an algorithm that allows for the rational design of smart combinatorial libraries for pathway optimization thereby minimizing the use of experimental resources. We demonstrate the utility of RedLibs for the design of ribosome-binding site libraries by in silico and in vivo screening with fluorescent proteins and perform a simple two-step optimization of the product selectivity in the branched multistep pathway for violacein biosynthesis, indicating a general applicability for the algorithm and the proposed heuristics. We expect that RedLibs will substantially simplify the refactoring of synthetic metabolic pathways.
Development of Sensor Component for Terrain Evaluation and Obstacle Detection for an Unmanned Autonomous Vehicle (2007)

Abstract : Applications of autonomous vehicles are found in various diversified fields including defense, agriculture, mining, and space exploration. For successful operation of an autonomous vehicle, the vehicle has to dynamically interact with the environment around it. This dissertation presents the development and implementation of a sensor component to represent the surrounding environment around an autonomous vehicle. The environment is modeled as a grid and each cell in the grid is assigned a traversability value. Each of the two algorithms, obstacle detection and terrain evaluation, have certain advantages and limitations. Also like any other sensor algorithm, these two algorithms have some uncertainties associated with their outputs. In my work these algorithms are fused together to complement the uncertainties and limitations of each of them, and outputs of the two algorithms are fused using the certainty factors approach.
Microcomputers and Electronic Instrumentation: MAKING THE RIGHT CONNECTIONS (1994)

RETURN TO ISSUEPREVAdvertisementNEXTMicrocomputers and Electronic Instrumentation: MAKING THE RIGHT CONNECTIONSCite this: Chem. Eng. News 1994, 72, 33, 38Publication Date (Print):August 15, 1994Publication History Published online11 November 2010Published inissue 15 August 1994https://doi.org/10.1021/cen-v072n033.p038Copyright © 1994 American Chemical SocietyArticle Views80Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (429 KB) Get e-Alerts
Extensible framework for graphical representation of HDL models and Simulation Results (2013)

Digital systems models complexity requires often representation of their structure in graphical form. Also the simulation results of the models are often very extensive and for their effective browsing the proper representation is needed. We have proposed the methods for visualization of the digital systems models structure as well as their simulation outputs. The methods were designed to support the three most popular hardware description languages (HDLs) — VHDL, Verilog, and SystemC. For each language the algorithms were developed for transformation of model structure and simulation results into the common output forms that can be stored in common file formats for all the languages. To verify the solution all the methods were integrated into one system allowing to browse connections between modules on each level of model hierarchy. The simulation results can be displayed in the traditional waveform style, however the values of ports and signals at a particular time can be displayed directly in the visualized structure as well.
Mechanism for the stereospecific polymerization of olefins by Ziegler–Natta catalysts (1978)

A mechanism for the stereospecific polymerization of olefins by Ziegler–Natta catalysts is developed which differs significantly from previous mechanisms in the proposal that it proceeds via a 1,2-hydrogen shift from the α-carbon of the polymer chain and formation of metallocycle and carbene intermediates.
아바칸 8 타쉬트익 문화의 고분 유적 (2018)

2014~2015년 아바칸 8 무덤에서 고고학적 발굴을 하면서 광중과 두 개의무덤 및 구덩이 등 타쉬트익 문화와 관련된 몇 가지 대상을 조사했다. 10.5×11.5m의광중에서 화장된 것, 가면 조각, 청동 부적 및 목재 제품의 부분 등 95개의 부장품이발견되었다. 그 결과 매장지를 재건축해 볼 수 있었다. 무덤에서는 미이라 형태로 하는매장의식에 따라 묻혀 있었고, 측면 화장된 부분에서는 마스크 조각이 발견되었다. 3개의 토기와 희생된 양이 발견되었다. 방사성탄소연대 결과 3세기 후반에서 4세기 초의무덤이라 생각된다.
Fatigue of Composite Materials and Substructures for Wind Turbine Blades (2002)

This report presents the major findings of the Montana State University Composite Materials Fatigue Program from 1997 to 2001, and is intended to be used in conjunction with the DOE/MSU Composite Materials Fatigue Database. Additions of greatest interest to the database in this time period include environmental and time under load effects for various resin systems; large tow carbon fiber laminates and glass/carbon hybrids; new reinforcement architectures varying from large strands to prepreg with well-dispersed fibers; spectrum loading and cumulative damage laws; giga-cycle testing of strands; tough resins for improved structural integrity; static and fatigue data for interply delamination; and design knockdown factors due to flaws and structural details as well as time under load and environmental conditions. The origins of a transition to increased tensile fatigue sensitivity with increasing fiber content are explored in detail for typical stranded reinforcing fabrics. The second focus of the report is on structural details which are prone to delamination failure, including ply terminations, skin-stiffener intersections, and sandwich panel terminations. Finite element based methodologies for predicting delamination initiation and growth in structural details are developed and validated, and simplified design recommendations are presented.
Anatomy, Head and Neck, Eye Corrugator Muscle (2019)

The corrugator (or corrugator supercilii) muscles are a pair of muscles located at the medial end of the eyebrow. They have recognition as significant muscles in the glabellar and central forehead regions. The corrugator supercilii muscles (CSM) play a major role in elevating the medial segment of the eyebrow, depressing the lateral portion of the eyebrow and are responsible for producing vertical frown lines.
Clickstream Log Acquisition with Web Farming (2005)

Collecting customer interaction data on the e-business Web sites and portals help to figure out customer behavior and build customer profile, and then perform personalized services. Traditional Web server log is hard to be associated with specific customer and impossible to log the complete actions and movements of customers across Web sites. Collecting clickstream log at the application layer with Web farming technology helps to seamlessly integrate Web usage data with other customer related data. This model can be developed as a common plugin for most existing e-business Web sites and portals.
Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site (2012)

Glucose transporter (GLUT)1 has become an attractive target to block glucose uptake in malignant cells since most cancer cells overexpress GLUT1 and are sensitive to glucose deprivation. Methylxanthines are natural compounds that inhibit glucose uptake; however, the mechanism of inhibition remains unknown. Here, we used a combination of binding and glucose transport kinetic assays to analyze in detail the effects of caffeine, pentoxifylline, and theophylline on hexose transport in human erythrocytes. The displacement of previously bound cytochalasin B revealed a direct interaction between the methylxanthines and GLUT1. Methylxanthines behave as noncompetitive blockers (inhibition constant values of 2-3 mM) in exchange and zero-trans efflux assays, whereas mixed inhibition with a notable uncompetitive component is observed in zero-trans influx assays (inhibition constant values of 5-12 mM). These results indicate that methylxanthines do not bind to either exofacial or endofacial d-glucose-binding sites but instead interact at a different site accessible by the external face of the transporter. Additionally, infinite-cis exit assays (Sen-Widdas assays) showed that only pentoxifylline disturbed d-glucose for binding to the exofacial substrate site. Interestingly, coinhibition assays showed that methylxanthines bind to a common site on the transporter. We concluded that there is a methylxanthine regulatory site on the external surface of the transporter, which is close but distinguishable from the d-glucose external site. Therefore, the methylxanthine moiety may become an attractive framework for the design of novel specific noncompetitive facilitative GLUT inhibitors.
Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV) (2006)

Little is known about the identities and roles of antigen-presenting cells upon exposure to antigens of respiratory syncytial virus (RSV). Here, we focused on elucidating the importance of alveolar macrophages in conferring protective immunity in mice administered a liposome-encapsulated recombinant fragment of the RSV G protein. Mice were depleted of alveolar macrophages by intranasal inoculation of liposome-encapsulated dichloromethylenediphosphonic acid (DMDP). Mice depleted of alveolar macrophages prior to immunization developed reduced levels of serum RSV-neutralizing antibody and showed dramatically impaired protection against RSV challenge. The severity of interstitial inflammation was also markedly reduced in macrophage-depleted mice. In conclusion, this study demonstrates a pivotal role for alveolar macrophages during exposure to liposome-encapsulated RSV antigen in initiating both protective and histopathological responses against RSV.
Phase‐contrast magnetic resonance imaging measurements in intracranial aneurysms in vivo of flow patterns, velocity fields, and wall shear stress: Comparison with computational fluid dynamics (2009)

Evolution of intracranial aneurysms is known to be related to hemodynamic forces such as wall shear stress (WSS) and maximum shear stress (MSS). Estimation of these parameters can be performed using numerical simulations with computational fluid dynamics (CFD), but can also be directly measured with magnetic resonance imaging (MRI) using a time-dependent 3D phase-contrast sequence with encoding of each of the three components of the velocity vectors (7D-MRV). To study the accuracy of 7D-MRV in estimating these parameters in vivo, in comparison with CFD, 7D-MRV and patient-specific CFD modeling was performed for 3 patients who had intracranial aneurysms. Visual and quantitative analyses of the flow pattern and distribution of velocities, MSS, and WSS were performed using the two techniques. Spearman's coefficients of correlation between the two techniques were 0.56 for the velocity field, 0.48 for MSS, and 0.59 for WSS. Visual analysis and Bland-Altman plots showed good agreement for flow pattern and velocities but large discrepancies for MSS and WSS. These results indicate that 7D-MRV can be used in vivo to measure velocity flow fields and for estimating MSS and WSS. Currently, however, this method cannot accurately quantify the latter two parameters.
[PPAR gamma agonist rosiglitazone alleviates hypoxia/reoxygenation-induced oxidative stress and apoptosis in rat cardiac myocytes]. (2009)

Rosiglitazone can significantly reduce hypoxia/reoxygenation-induced oxidative stress in cardiac myocytes, improve the cell viability and dose-dependently reduce the apoptotic rate of the cardiac myocytes.
Ceramic Materials and Color in Dentistry (2010)

Since the introduction of metal ceramic crowns, clinicians and researchers have been looking for a restorative system that can associate beauty, strength and durability, but without the presence of a metallic infrastructure. Indeed, dental ceramics are materials that come aesthetically closest to natural teeth. With the improvement of ceramic systems, it has been possible to combine the excellent aesthetic characteristics of this material with a considerable resistance to fracture. It is imperative to understand the phenomenon of color and its variables in the oral cavity, as well as associate different techniques of color selection and communication, in order to get prostheses that look closer to natural dental tissues.
Relationship between periodontitis and hepatic condition in Japanese women. (2006)

The liver is an important organ closely associated with lipid and glucose metabolism. This study was performed to clarify the relationship between periodontitis and hepatic condition in apparently healthy Japanese women. A cross-sectional study was performed on 172 apparently healthy, dentulous Japanese women (20-59 years old) who attended a health promotion program at Fukuoka Health Promotion Center. After multivariate adjustment for age, smoking history and oral hygiene, which were known risk factors for periodontitis, the incidence of periodontitis (deepest probing depth > or =4 mm) in females was significantly increased with elevated serum levels of aspartate aminotransferase (AST, p < 0.01), alanine aminotransferase (ALT, p < 0.01) and cholinesterase (p < 0.001), and an AST-to-ALT ratio of less than one (p = 0.02). Further adjustment for either body mass index (BMI) or percent body fat did not attenuate these relationships. These results suggest that hepatic steatosis is associated with periodontitis in Japanese women.
Multichannel grating cavity (MGC) laser transmitter for wavelength division multiplexing applications (1991)

A detailed experimental investigation of a wavelength switchable multichannel grating cavity (MGC) laser is reported with properties particularly suitable for applications in broadband wavelength division multiplexing systems. The source consists of a bar of laser ridges with one facet antireflection (AR) coated, a collimating lens and a diffraction grating. By changing the electrical bias to individual laser ridges, precise wavelength switching is achieved across the complete gain spectrum of the diode laser material. A detailed investigation of multiple simultaneous channel generation is reported and a method is outlined to overcome channel crosstalk. Good agreement between theory and experiment is reported.
A Flavonoid Fraction from Cranberry Extract Inhibits Proliferation of Human Tumor Cell Lines (2004)

In light of the continuing need for effective anticancer agents, and the association of fruit and vegetable consumption with reduced cancer risk, edible plants are increasingly being considered as sources of anticancer drugs. Cranberry presscake (the material remaining after squeezing juice from the berries), when fed to mice bearing human breast tumor MDA-MB-435 cells, was shown previously to decrease the growth and metastasis of tumors. Therefore, further studies were undertaken to isolate the components of cranberry that contributed to this anticancer activity, and determine the mechanisms by which they inhibited proliferation. Using standard chromatographic techniques, a warm-water extract of cranberry presscake was fractionated, and an acidified methanol eluate (Fraction 6, or Fr6) containing flavonoids demonstrated antiproliferative activity. The extract inhibited proliferation of 8 human tumor cell lines of multiple origins. The androgen-dependent prostate cell line LNCaP was the most sensitive of those tested (10 mg/L Fr6 inhibited its growth by 50%), and the estrogen-independent breast line MDA-MB-435 and the androgen-independent prostate line DU145 were the least sensitive (250 mg/L Fr6 inhibited their growth by 50%). Other human tumor lines originating from breast (MCF-7), skin (SK-MEL-5), colon (HT-29), lung (DMS114), and brain (U87) had intermediate sensitivity to Fr6. Using flow cytometric analyses of DNA distribution (cell cycle) and annexin V-positivity (apoptosis), Fr6 was shown in MDA-MB-435 cells to block cell cycle progression (P < 0.05) and induce cells to undergo apoptosis (P < 0.05) in a dose-dependent manner. Fr6 is potentially a source of a novel anticancer agent.