gebhart/patrepeval huggingface dataset:
Spontaneous organisation, pattern models, and music (2004)

Pattern theory provides a set of principles for constructing generative models of the information contained in natural signals, such as images or sound. Consequently, it also represents a useful language within which to develop generative systems of art. A pattern theory inspired framework and set of algorithms for interactive computer music composition are presented in the form of a self-organising hidden Markov model – a modular, graphical approach to the representation and spontaneous organisation of sound events in time and in parameter space. The result constitutes a system for composing stochastic music which incorporates creative and structural ideas such as uncertainty, variability, hierarchy and complexity, and which bears a strong relationship to realistic models of statistical physics or perceptual systems. The pattern theory approach to composition provides an elegant set of organisational principles for the production of sound by computer. Further, its machine learning underpinnings suggest many interesting applications to emergent tasks concerning the learning and creative modification of musical forms.
Cytotoxicity of Quantum Dots Used for <i>In Vitro</i> Cellular Labeling: Role of QD Surface Ligand, Delivery Modality, Cell Type, and Direct Comparison to Organic Fluorophores (2013)

Interest in taking advantage of the unique spectral properties of semiconductor quantum dots (QDs) has driven their widespread use in biological applications such as in vitro cellular labeling/imaging and sensing. Despite their demonstrated utility, concerns over the potential toxic effects of QD core materials on cellular proliferation and homeostasis have persisted, leaving in question the suitability of QDs as alternatives for more traditional fluorescent materials (e.g., organic dyes, fluorescent proteins) for in vitro cellular applications. Surprisingly, direct comparative studies examining the cytotoxic potential of QDs versus these more traditional cellular labeling fluorophores remain limited. Here, using CdSe/ZnS (core/shell) QDs as a prototypical assay material, we present a comprehensive study in which we characterize the influence of QD dose (concentration and incubation time), QD surface capping ligand, and delivery modality (peptide or cationic amphiphile transfection reagent) on cellular viability in three human cell lines representing various morphological lineages (epithelial, endothelial, monocytic). We further compare the effects of QD cellular labeling on cellular proliferation relative to those associated with a panel of traditionally employed organic cell labeling fluorophores that span a broad spectral range. Our results demonstrate the important role played by QD dose, capping ligand structure, and delivery agent in modulating cellular toxicity. Further, the results show that at the concentrations and time regimes required for robust QD-based cellular labeling, the impact of our in-house synthesized QD materials on cellular proliferation is comparable to that of six commercial cell labeling fluorophores. Cumulatively, our results demonstrate that the proper tuning of QD dose, surface ligand, and delivery modality can provide robust in vitro cell labeling reagents that exhibit minimal impact on cellular viability.
Diagnosis and treatment of non-infectious and infectious foal diarrhoea (2008)

Diagnose und Behandlung nicht infektiser und
Rapid development of signal processors and the RASSP program (2002)

This paper presents two case studies of the rapid development of military signal processors and a description of how the experiences learned on these programs are being leveraged into an ARPA/Tri-Service initiative. The two case studies emphasize end-to-end system simulation and the use of rapid prototyping tools and special hardware for rapid development. Rapid Prototyping of Application Specific Signal Processors, or RASSP, is an initiative to create a new process for the development of military signal processors. The objective of RASSP is to specify a process which both reduces the development time and the cost of military signal processing systems while improving their quality and their long term supportability. RASSP processors are meant to be incrementally upgradable over long development and life cycles. While RASSP represents a significantly harder problem than the two examples described here, the lessons learned in these examples are being incorporated in the RASSP approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A picosecond thin-rod Yb:YAG regenerative laser amplifier with the high average power of 20 W (2013)

A high-average-power, laser-diode-pumped, picosecond-pulse regenerative amplifier was developed using the thin-rod Yb:YAG (yttrium aluminum garnet) laser architecture. This architecture has a complete set of favorable properties for the cost-effective, high-average-power, and high-peak-power lasers. These include low amplified spontaneous emission with high gain and high repetition rate. For the amplifier system, an average output power of 20 W was achieved at a pulse repetition rate of 100 kHz, which corresponds to an output pulse energy of 200 μJ with an output pulse width of 2 ps.
Effect of combined coenzyme Q10 and d-<i>α</i>-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners (1998)

To test the effects of combined coenzyme Q10 (Q10) and d-alpha-tocopheryl acetate supplementation on exercise-induced oxidative stress and muscular damage we conducted a double-blind study in 37 moderately trained male marathon runners. These were randomly allocated to receive either an antioxidant cocktail: 90 mg of Q10 and 13.5 mg of d-alpha-tocopheryl acetate daily (18 men) or placebo (19 men) for three weeks before a marathon (42km) run. Just before the run, plasma Q10 was 282% (p < 0.0001) and plasma vitamin E 16% (p < 0.007) higher in the supplemented group, than in the placebo group. Also the proportion of plasma ubiquinol of total Q10, an indication of plasma redox status in vivo, was significantly higher in the supplemented group. Furthermore, the susceptibility of the VLDL + LDL fraction, to copper-induced oxidation, was significantly reduced in the supplemented group, compared to the placebo group. The exercise increased lipid peroxidation significantly in both study groups, as assessed by the elevated proportion LDL of LDL and the increased susceptibility of lipoproteins to copper induced oxidation. However, the supplementation had no effect on lipid peroxidation or on the muscular damage (increase in serum creatine kinase activity or in plasma lactate levels) induced by exhaustive exercise. Plasma ascorbate, Q10, whole blood glutathione and serum uric acid concentrations increased during the exercise, elevating significantly the TRAP value of plasma by 10.3% and the proportion of plasma ubiquinol of total Q10 by 4.9%. These results suggest that even though exercise increases plasma lipid peroxidation, it also elevates the antioxidative capacity of plasma, as assessed by the increased plasma TRAP and the proportion of Q10H2 of total Q10. However, prior supplementation with small doses of Q10 and d-alpha-tocopheryl acetate neither attenuates the oxidation of lipoproteins nor muscular damage induced by exhaustive exercise such as encountered in a marathon run.
Secretion of Saccharomyces diastaticus glucoamylase from Schizosaccharomyces pombe. (1984)

Fission yeast, Schizosaccharomyces pombe, is used for brewing in the tropics e.g. South Africa and Java, since it is more thermotol-
Raman Spectra of Liquid MgCl2 and Liquid MgCl2–KCl System (1966)

Raman spectra of molten MgCl2, MgCl2–KCl, and MgCl2–2KCl were recorded, at 730°, 525°, and 475°C, respectively, using a Cary 81 Raman spectrophotometer. Liquid MgCl2 exhibits three Raman lines with frequencies 269, 214, and 142 cm−1, which are explainable on the basis of the presence of MgCl64— ions with octahedral configuration. Liquid MgCl2–KCl exhibits four Raman lines with frequencies 451, 250, 208, and 158 cm−1; and their polarization characteristics indicate the existence of MgCl3− ions with pyramidal configuration C3v. The Raman spectrum of liquid MgCl2–2KCl is almost similar to that of liquid MgCl2–KCl. Force constants for the various Mg–Cl ionic species were calculated using generalized valence forces.
Automatic design of conformal cooling channels in injection molding tooling (2018)

The generation of cooling system plays an important role in injection molding design. A conformal cooling system can effectively improve molding efficiency and product quality. This paper provides a generic approach for building conformal cooling channels. The centrelines of these channels are generated in two steps. First, we extract conformal loops based on geometric information of product. Second, centrelines in spiral shape are built by blending these loops. We devise algorithms to implement the entire design process. A case study verifies the feasibility of this approach.
Lactic Dehydrogenase Inhibitors in NAD (1970)

Abstract Commercial samples of nicotinamide adenine dinucleotide (NAD) contain various amounts of one or more lactic dehydrogenase (LDH) inhibitors but not the inhibitor described in the reduced coenzyme, NADH. The kinetic assay for LDH, in which a high concentration of NAD is used, was more seriously influenced by the source of NAD than a tetrazolium-coupled colorimetric procedure that requires much less coenzyme.
Inhomogeneous interface laser mirror coatings (1979)

Methods of improving the durability of thin-film laser mirror coatings for 10.6 microm using thorium fluoride, zinc selenide, and zinc sulfide materials have been investigated. The largest improvement in film durability was obtained by using inhomogeneous interface fabrication for all the dielectric-dielectric interfaces and by incorporating cerium fluoride protective overcoating material into the film design. Experimental results are given for enhanced reflectors, polarization-selective coatings, and buried-grating aperture-sharing coatings designed for high-power laser applications.
Mitosis in Living Budding Yeast: Anaphase A But No Metaphase Plate (1997)

Chromosome movements and spindle dynamics were visualized in living cells of the budding yeast Saccharomyces cerevisiae. Individual chromosomal loci were detected by expression of a protein fusion between green fluorescent protein (GFP) and the Lac repressor, which bound to an array of Lac operator binding sites integrated into the chromosome. Spindle microtubules were detected by expression of a protein fusion between GFP and Tub1, the major alpha tubulin. Spindle elongation and chromosome separation exhibited biphasic kinetics, and centromeres separated before telomeres. Budding yeast did not exhibit a conventional metaphase chromosome alignment but did show anaphase A, movement of the chromosomes to the poles.
Instruction generation for hybrid reconfigurable systems (2002)

Future computing systems need to balance flexibility, specialization, and performance in order to meet market demands and the computing power required by new applications. Instruction generation is a vital component for determining these trade-offs. In this work, we present theory and an algorithm for instruction generation. The algorithm profiles a dataflow graph and iteratively contracts edges to create the templates. We discuss how to target the algorithm toward the novel problem of instruction generation for hybrid reconfigurable systems. In particular, we target the Strategically Programmable System, which embeds complex computational units such as ALUs, IP blocks, and so on into a configurable fabric. We argue that an essential compilation step for these systems is instruction generation, as it is needed to specify the functionality of the embedded computational units. In addition, instruction generation can be used to create soft reconfigurable macros---tightly sequenced prespecified operations placed in the reconfigurable fabric.
MOVING GOODS, NOT PAPERWORK (2000)

Electronic Data Interchange and the internet are making shipping by rail easier and more convenient than ever before. Customers can fill out bills of lading forms on the computer which insures more accuracy. The internet accessible information available to the customer ranges from mileage rates, tariffs, destination/arrival times and route tracking and tracing. The more convenient, complete and accessible the information, the better to serve railroads, freight companies and customers.
Metal–insulator–metal capacitors by using electron cyclotron resonance plasma-SiO2 (1995)

This paper describes the fabrication process and the reliable characteristics of a metal–insulator–metal capacitor using electron cyclotron resonance plasma-SiO2 as an insulator film. The metal–insulator–metal capacitors are additionally fabricated during the Al multilevel interconnection process since the deposition temperature of electron cyclotron resonance plasma-SiO2 is below 200 °C. Also, the leakage current characteristics of the film are excellent even without densification at high temperature. The experimental results confirm that a metal–insulator–metal capacitor fabrication process using electron cyclotron resonance plasma-SiO2 can be applied to analog large scale integration implementation.
Estimation of Soil Properties by Orbital and Laboratory Reflectance Means and its Relation with Soil Classification (2013)

Bentham Science - STM publisher of online and print journals, and related print/online book series. Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences.
AAV8-mediated gene transfer of microRNA-132 improves beta cell function in mice fed a high-fat diet (2018)

MicroRNAs have emerged as essential regulators of beta cell function and beta cell proliferation. One of these microRNAs, miR-132, is highly induced in several obesity models and increased expression of miR-132 in vitro modulates glucose-stimulated insulin secretion. The aim of this study was to investigate the therapeutic benefits of miR-132 overexpression on beta cell function in vivo. To overexpress miR-132 specifically in beta cells, we employed adeno-associated virus (AAV8)-mediated gene transfer using the rat insulin promoter in a double-stranded, self-complementary AAV vector to overexpress miR-132. Treatment of mice with dsAAV8-RIP-mir132 increased miR-132 expression in beta cells without impacting expression of miR-212 or miR-375. Surprisingly, overexpression of miR-132 did not impact glucose homeostasis in chow-fed animals. Overexpression of miR-132 did improve insulin secretion and hence glucose homeostasis in high-fat diet-fed mice. Furthermore, miR-132 overexpression increased beta cell proliferation in mice fed a high-fat diet. In conclusion, our data show that AAV8-mediated gene transfer of miR-132 to beta cells improves beta cell function in mice in response to a high-fat diet. This suggests that increased miR-132 expression is beneficial for beta cell function during hyperglycemia and obesity.
Integrated medical care management and behavioral risk factor reduction for multicondition patients: behavioral outcomes of the TEAMcare trial (2013)

Diet and activity generally improved for those receiving the intervention, while there were no differences in some aspects of diet (fruit and vegetable and high-fat food intake), smoking status and sitting time between conditions in the TEAMcare trial.
Synthesis of testable RTL designs (2002)

With several commercial tools becoming available, the high-level synthesis of application-specific integrated circuits is finding wide spread acceptance in VLSI industry today. Existing tools for synthesis focus on optimizing cost while meeting performance constraints or vice versa. Yet, verification and testing have emerged as major concerns of IC vendors since the repercussions of chips being recalled are far-reaching. In this paper, we concentrate on the synthesis of testable RTL designs using techniques from Artificial Intelligence. We present an adaptive version of the well known Simulated Annealing algorithm and describe its application to a combinatorial optimization problem arising in the high-level synthesis of digital systems. The conventional annealing algorithm was conceived with a single perturb operator which applies a small modification to the existing solution to derive a new solution. The Metropolis criterion is then used to accept or reject the new solution. In some of the complex optimization problems arising in VLSI design, a set of perturb functions become necessary, leading to the question of how to select a particular function for modifying the current system configuration. The adaptive algorithm described here uses the concept of reward and penalty from the theory of learning automata to "learn" to apply the appropriate perturb function. We have applied both the conventional simulated annealing algorithm and the adaptive simulated annealing algorithm to the problem of testability-oriented datapath synthesis for signal processing applications. Our experimental results indicate that the adaptive algorithm can yield better solutions in shorter time.
Persistence of Healthcare-Associated (Nosocomial) Infections Due to Inadequate Hand Hygiene: Part 3—Application of Human Factors Engineering to an Ozone Hand Sanitizer (2018)

Compliance to hand-hygiene guidelines in healthcare facilities remains disappointingly low for a variety of human-factors (HF) reasons. A device HF-engineered for convenient and effective use even under high-workload conditions could contribute to better compliance, and consequently to reduction in healthcare-acquired infections. We present an overview of the efficacy of a passive hand-spray device that uses solubilized ozone—a strong, safe, non-irritant biocide having broad-spectrum antimicrobial properties—on glass surface, pigskin, and synthetic human skin matrix.
Synthetic Hypoglycemic Agents. I<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Hypoglycemic Agents. I1Harry L. YaleCite this: J. Am. Chem. Soc. 1953, 75, 3, 675–678Publication Date (Print):February 1, 1953Publication History Published online1 May 2002Published inissue 1 February 1953https://pubs.acs.org/doi/10.1021/ja01099a048https://doi.org/10.1021/ja01099a048research-articleACS PublicationsRequest reuse permissionsArticle Views231Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunoaffinity purification of α‐momorcharin from bitter melon seeds (<i>Momordica charantia</i>) (2011)

α-Momorcharin (α-MMC), a type I ribosome-inactivating protein (RIP), has shown therapeutic potential such as anti-tumor and anti-viral agent. Traditional process of α-MMC purification from bitter melon seeds was time consuming and low efficient. To take this challenge, we made an affinity matrix by coupling the monoclonal antibody (McAb) with Sepharose 4B. Using this attractive strategy, 196 mg of α-MMC was obtained from 100 g of bitter melon seeds as the starting material. The yield of the protein was 2.7%. The homogeneity and properties of the protein were assessed by SDS-PAGE, acidic PAGE, RP-HPLC and N-terminal sequence as well as Western blot. Purified α-MMC showed remarkable inhibition to the melanoma cell line JAR and EMT-62058. In addition, it also displayed obvious inhibition on hepatitis B virus (HBV). This work provided a simple, rapid and efficient approach for α-MMC purification from Momordica charantia.
On sequential simulation-based methods for Bayesian filtering (1998)

Abstract. In this report, we present an overview of sequential simulationbased methods for Bayesian filtering of nonlinear and non-Gaussian dynamic models. It includes in a general framework numerous methods proposed independently in various areas of science and proposes some original developments.
Generalized Emulation Services for Mach 3.0 Overview, Experiences and Current Status (1991)

This paper reports on an ongoing project to developa general understanding of the problems encountered when building emulators for various operating systems at the user-level on top of a Mach 3.0 micro-kernel, and to propose a common framework to construct emulations for a wide range of target systems and environments. It presents an overview and discussion of the major techniques and experiments that characterize the design of the proposed system. Some of the relevant aspects include the combination of several independent servers to create a complete system, generic service interfaces relying on the emulation library as an interface translator, the use of object-oriented technology to define standard interfaces and to simplify the implementation of common facilities, moving portions of the system state and processing from the servers into a smart emulation library, and a few general-purpose facilities that simplify the generation of a complete system. A number of practical observation...
Mass Screening for Genetic Disease (1972)

Automation has already brought our screening capability to the point where the same specimen can be used to detect a number of hereditary aminoacidurias in addition to PKU. Yet application falls far behind: only six laboratories in the U. S. now do such automated multiple testing. Regionalizing the effort could close this gap—and involve practically no increase in cost over that of screening for PKU alone.