gebhart/patrepeval huggingface dataset:
Gubernacular development in Müllerian inhibiting substance receptor‐deficient mice (2002)

Objective To determine, in mice with disrupted Müllerian inhibiting substance (MIS) receptor genes, whether MIS affects gubernacular development; MIS causes Müllerian duct regression and is proposed to be involved in the first stage of testicular descent, because gubernacular development is abnormal in humans with persistent Müllerian duct syndrome. Materials and methods Ten wild‐type, 11 heterozygotic and 12 homozygotic mice for MIS receptor mutations were killed at 17.5 or 18.5 days after conception or at birth, to provide serial sagittal sections of the pelvis. The amount of cremaster muscle, mitotic bodies in the gubernacular bulb, and gubernacular size were quantified by computer analysis (four mice/group). Results Müllerian ducts were present in the homozygous mutants, partially present in the heterozygotes and absent in the wild‐type controls. All mice had descended testes. The cremaster muscle was significantly less developed in homozygous mutants than in wild‐type controls ( P < 0.001) and heterozygotes ( P < 0.01) at birth. The mitotic index between the gubernacula of all groups was indistinguishable. There was no statistical difference in gubernacular area amongst the groups. Poor cremaster muscle development in homozygous mutants gave the muscle a loose mesenchymal appearance. Conclusions Although there was an observable effect on cremaster muscle development in these mutant mice, gubernacular development and testicular descent were otherwise normal, and thus there must be other reasons for the observed differences in humans with persistent Müllerian duct syndrome.
An <i>in vitro</i> study of the reduction in wear of metal-on-metal hip prostheses using surface-engineered femoral heads (2002)

Although the wear of existing metal-on-metal (MOM) hip prostheses (1 mm3/10(6) cycles) is much lower than the more widely used polyethylene-on-metal bearings, there are concerns about the toxicity of metal wear particles and elevated metal ion levels, both locally and systemically, in the human body. The aim of this study was to investigate the possibility of reducing the volume of wear, the concentration of metal debris and the level of metal ion release through using surface-engineered femoral heads. Three thick (8-12 microm) coatings (TiN, CrN and CrCN) and one thin (2 microm) coating (diamond-like carbon, DLC), were evaluated on the femoral heads when articulating against high carbon content cobalt-chromium alloy acetabular inserts (HC CoCrMo) and compared with a clinically used MOM cobalt-chromium alloy bearing couple using a physiological anatomical hip joint simulator (Leeds Mark II). This study showed that CrN, CrCN and DLC coatings produced substantially lower wear volumes for both the coated femoral heads and the HC CoCrMo inserts. The TiN coating itself had little wear, but it caused relatively high wear of the HC CoCrMo inserts compared with the other coatings. The majority of the wear debris for all half-coated couples comprised small, 30 nm or less, CoCrMo metal particles. The Co, Cr and Mo ion concentrations released from the bearing couples of CrN-, CrCN- and DLC-coated heads articulating against HC CoCrMo inserts were at least 7 times lower than those released from the clinical MOM prostheses. These surface-engineered femoral heads articulating on HC CoCrMo acetabular inserts produced significantly lower wear volumes and rates, and hence lower volumetric concentrations of wear particles, compared with the clinical MOM prosthesis. The substantially lower ion concentration released by these surface-engineered components provides important evidence to support the clinical application of this technology.
Mineral Requirements for Growth and Callus Initiation of Tissue Explants Excised from Mature Coconut Palms (<i>Cocos nucifera</i>) and Cultured <i>in vitro</i> (1976)

Abstract Growth of stem, leaf, and inflorescence explants from mature coconut ( Cocos nucifera L.) palms on a new mineral formulation (Y3) was superior to that on the minerals of White, Heller, or Murashige and Skoog. Cell division in the upper part of cultured explants gave rise to a layer of white callus within a month. The effects of omitting entirely or altering the concentration of individual elements in the Y3 formulation were investigated. It was concluded that growth on White's and Heller's minerals was seriously limited by deficiencies in macro‐elements, i.e. nitrogen (particularly ammonium), potassium and phosphorus, as well as micro‐elements, i.e. iron, iodine and molybdenum. The Murashige and Skoog formulation, on the other hand, was deficient only in certain micro‐elements (particularly iodine).
A unified approach to noise removal, image enhancement, and shape recovery (1996)

We present a unified approach to noise removal, image enhancement, and shape recovery in images. The underlying approach relies on the level set formulation of the curve and surface motion, which leads to a class of PDE-based algorithms. Beginning with an image, the first stage of this approach removes noise and enhances the image by evolving the image under flow controlled by min/max curvature and by the mean curvature. This stage is applicable to both salt-and-pepper grey-scale noise and full-image continuous noise present in black and white images, grey-scale images, texture images, and color images. The noise removal/enhancement schemes applied in this stage contain only one enhancement parameter, which in most cases is automatically chosen. The other key advantage of our approach is that a stopping criteria is automatically picked from the image; continued application of the scheme produces no further change. The second stage of our approach is the shape recovery of a desired object; we again exploit the level set approach to evolve an initial curve/surface toward the desired boundary, driven by an image-dependent speed function that automatically stops at the desired boundary.
FoundationDB Record Layer: A Multi-Tenant Structured Datastore (2019)

The FoundationDB Record Layer is an open source library that provides a record-oriented data store with semantics similar to a relational database implemented on top of FoundationDB, an ordered, transactional key-value store. The Record Layer provides a lightweight, highly extensible way to store structured data. It offers schema management and a rich set of query and indexing facilities, some of which are not usually found in traditional relational databases, such as nested record types, indexes on commit versions, and indexes that span multiple record types. The Record Layer is stateless and built for massive multi-tenancy, encapsulating and isolating all of a tenant's state, including indexes, into a separate logical database. We demonstrate how the Record Layer is used by CloudKit, Apple's cloud backend service, to provide powerful abstractions to applications serving hundreds of millions of users. CloudKit uses the Record Layer to host billions of independent databases, many with a common schema. Features provided by the Record Layer enable CloudKit to provide richer APIs and stronger semantics with reduced maintenance overhead and improved scalability.
NFSv4 Version Management (2014)

This document describes the management of versioning within the NFSv4
family of protocols. It covers the creation of minor versions, the
addition of OPTIONAL features to existing minor versions, and the
correction of flaws in features already published as Proposed
Standards. The rules for minor versioning set out in this document
supersede the multiple sets of minor versioning rules in RFC3530 and
RFC5661.
A Simple Approach to a Statistical Path Loss Model for Indoor Communications (1997)

Path-loss in indoor environments is investigated at 1.8 GHz, using a power-law model where the exponent of the distance is the descriptive random variable. The model is extremely simple and easily applicable in practice by working engieers who need only make a few measurements to get a knowledge of path loss sufficient for many applications. The model fits well experimental data in various environments under different propagation conditions, including cross polarization, and the observed behavior of the exponent suggests the possibility of using only one distribution function to statistically characterize path loss.
Estimates of effectiveness and reach for ‘return on investment’ modelling of smoking cessation interventions using data from England (2017)

Tax increases, indoor smoking bans, brief opportunistic physician advice and use of nicotine replacement therapy (NRT) for smoking reduction can all increase population quit attempt rates. Quit success rates can be increased by provision of NRT, varenicline, bupropion, nortriptyline, cytisine and behavioural support delivered through a variety of modalities. Parameter estimates for the effectiveness and reach of these interventions can contribute to return on investment estimates in support of national or regional policy decisions.
A population-based incidence of acute large vessel occlusions and thrombectomy eligible patients indicates significant potential for growth of endovascular stroke therapy in the USA (2016)

This study estimates an LVO incidence of 24 per 100 000 person-years (95% CI 20 to 28). A current estimated annual thrombectomy rate of three procedures per 100 000 people indicates significant potential increase in the volume of endovascular procedures and the need to develop systems of care.
Two extensions of the Viterbi algorithm (1991)

The problem of minimum-cost correction of a corrupted set of data that has been generated by a known finite state machine (FSM) is examined. The Viterbi algorithm is modified to correct insertions and deletions as well as errors, still using a trellis diagram that has the same number of states as the FSM that generates the uncorrupted data. Two problems are examined. In the first problem the data is given in the traditional form of a string so the novel aspect is that insertions and deletions are now corrected. In the second problem, a unique string need not be given, but a regular language is given, and any string belonging to the regular language is a possible data string. Again, deletion addition, and changes of symbols are corrected. A direct generalization of the Viterbi decoding algorithm is thus proved to be an efficient technique for solving a much wider class of problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hyaluronidase production in Streptococcus milleri in relation to infection. (1989)

One hundred and seven (41%) of 262 isolates of Streptococcus milleri, from human sources, produced hyaluronidase. Hyaluronidase production was commoner in beta haemolytic isolates 32 of 39 (82%), many of which were of Lancefield group F. But hyaluronidase was also found in alpha and non-haemolytic isolates, and in groups A, C, G, and non-groupable isolates. There was a strong association between hyaluronidase production and isolation from known internal abscesses (48/58, 83%) compared with isolates from the normal flora of uninfected sites (24/97, 25%). Isolates from 15 patients with endocarditis were uniformly negative, although 13 of 25 (52%) isolates from dental plaque produced the enzyme. Production of hyaluronidase may therefore be an important determinant in the pathogenicity of infection by S milleri and could be helpful in predicting the likelihood of deep purulent lesions in isolates from blood culture.
Response and Radiation of Structural Modes Excited by Sound (1962)

The response to sound and consequent sound radiation (“radiation scattering”) for one linear resonant mode of a part of a larger structure are analyzed for a general structure. A modal reciprocity relation is established between modal radiation resistance and the transfer function which relates incident sound pressure to modal (“generalized”) force in the absence of motion. Response and resonant scattering are also analyzed for excitation by noise. When all angles of incidence are equally probable, the means-quare response velocity is inversely proportional to modal stiffness and proportional to the fraction of total damping attributable to radiation; it is independent of all other characteristics of the structure.
Prognostic significance of cytokine modulation in non‐small cell lung cancer (2002)

Increased production of immunosuppressive interleukin-10 (IL-10) by non-small cell lung cancer (NSCLC) and increased serum IL-10 concentrations in NSCLC-patients have recently been correlated to reduced survival. We earlier demonstrated suppression of IL-2 secretion in whole blood cell cultures of NSCLC-patients. We now analyzed the influence of IL-2 secretion on survival in NSCLC-patients and the influence of IL-10 on IL-2 secretion. The correlation of the IL-2 producing ability of whole blood cells in response to PHA in 90 NSCLC-patients at the time of diagnosis to survival was calculated by Crit-level, the Kaplan-Meier method and the log-rank test. With a cut-off value of IL-2 production of 1,100 pg/ml by whole blood cells the difference in survival was significant with a p-value of 0.014. In the group with high and low IL-2, median survival was 14.1 and 9.7 months, respectively. In the subgroup of 33 surgically-treated patients the difference in survival was significant with a p-value of 0.011. In 14 patients with surgical resection of the tumor and high IL-2 at diagnosis and 19 patients with surgical resection, but low IL-2 at diagnosis, median survival was 86.2 and 11.3 months, respectively. Secretion of IL-2 in whole blood cell cultures from healthy individuals was inhibited in a dose-dependent manner upon addition of IL-10. Taken together, suppression of IL-2 secretion has prognostic significance for survival of NSCLC-patients and may be mediated by tumor-derived IL-10.
Magnesium concentrations in plasma and bone following enteral administration of Br-, Cl- and Mg++ in the form of different compounds and combinations. (1976)

In accordance with the results achieved in previous experiments the intestinal absorption of magnesium and its uptake into bone of rats were significantly improved when MgCl2 or mono-magnesium-mono-aspartate-hydrochloride (Mg asp. HCl) were used instead of mono-magnesium-di-l-aspartate (Mg asp.). Treatment with mono-magnesium-mono-aspartate-hydrobromide (Mg asp. HBr) resulted in remarkably elevated magnesium concentrations in plasma and bone. Since the animals were strongly sedated at the same time, we had to differentiate the influence of anesthesia from unspecific distress and specific actions of bromide and chloride, e.g. on intestinal uptake and/or renal excretion of Mg. Experiments in which the narcotic effect of bromide was reduced to moderate sedation by additional treatment with chloride would appear to suggest that both specific and unspecific mechanisms were involved. In additional experiments it was shown that the effects of Mg asp. plus KBr or Mg asp. plus KCl or CaCl2 were similar to those of the corresponding magnesium aspartate hydrohalogenides.
Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. (1984)

The role of macrophages in neovascularization of tumors was investigated by examining the ability of tumor-associated macrophages (TAM) and their conditioned culture media to induce neovascularization in the cornea of syngeneic rats and proliferation of bovine aortic endothelial cells in culture. TAM were isolated from a 3-methycholanthrene-induced fibrosarcoma propagated in F344 male rats by enzymatic dissociation and were purified by centrifugation through continuous Percoll density gradients, followed by adherence to fibronectin-coated dermal collagen gels. The angiogenic potential of (a) TAM and their 72-hour conditioned culture media, (b) whole tumor cell suspensions (WTCS), (c) tumor cell suspensions depleted of TAM (TCS), and (d) macrophage-depleted tumor cell suspensions reconstituted with TAM (TCS + TAM) were compared. Cells were injected directly; conditioned media were concentrated 10-fold, incorporated into slow-release Hydron pellets, and implanted intracorneally. Stimulation of bovine aortic endothelial cell growth by TAM was assayed in culture with TAM-conditioned media and compared with responses induced by conditioned media from peptone-elicited rat peritoneal exudate macrophages. TAM and their conditioned media induced neovascularization in 38 of 40 corneas (95%) and 15 of 17 corneas (88%), respectively. Maximal vessel ingrowth occurred by the 5th day of implantation. Neovascular responses induced by WTCS (24 of 26 corneas, 92%) and TCS (17 of 24 corneas, 71%) occurred on the 7th and 10th day, respectively. TCS + TAM induced neovascular responses comparable to those elicited by WTCS (19 of 20 corneas, 95%). Addition of TAM-conditioned media to bovine aortic endothelial cell cultures stimulated a 10-fold increase in cell number within 10 days. This growth stimulatory effect was comparable to or greater than responses induced by conditioned media from rat peritoneal macrophages. Our results demonstrate that TAM are potent stimulators of neovascularization and endothelial cell proliferation and that depletion of macrophages from tumor cell suspensions significantly decreased their angiogenic potential. This suggests that neovascularization of this tumor is mediated in part by macrophages.
RF-PUF: Enhancing IoT Security through Authentication of Wireless Nodes using In-situ Machine Learning (2018)

Traditional authentication in radio-frequency (RF) systems enable secure data communication within a network through techniques such as digital signatures and hash-based message authentication codes (HMAC), which suffer from key recovery attacks. State-of-the-art IoT networks such as Nest also use Open Authentication (OAuth 2.0) protocols that are vulnerable to cross-site-recovery forgery (CSRF), which shows that these techniques may not prevent an adversary from copying or modeling the secret IDs or encryption keys using invasive, side channel, learning or software attacks. Physical unclonable functions (PUF), on the other hand, can exploit manufacturing process variations to uniquely identify silicon chips which makes a PUF-based system extremely robust and secure at low cost, as it is practically impossible to replicate the same silicon characteristics across dies. Taking inspiration from human communication, which utilizes inherent variations in the voice signatures to identify a certain speaker, we present RF- PUF: a deep neural network-based framework that allows real-time authentication of wireless nodes, using the effects of inherent process variation on RF properties of the wireless transmitters (Tx), detected through in-situ machine learning at the receiver (Rx) end. The proposed method utilizes the already-existing asymmetric RF communication framework and does not require any additional circuitry for PUF generation or feature extraction. Simulation results involving the process variations in a standard 65 nm technology node, and features such as LO offset and I-Q imbalance detected with a neural network having 50 neurons in the hidden layer indicate that the framework can distinguish up to 4800 transmitters with an accuracy of 99.9% (~ 99% for 10,000 transmitters) under varying channel conditions, and without the need for traditional preambles.
Prolonged serum half-life of antineoplastic drugs by incorporation into the low density lipoprotein. (1990)

In vitro and in vivo data have indicated that tumor cells actively internalize the low density lipoprotein (LDL) from the circulation. In order to achieve a selective delivery of drugs to tumor cells via the LDL pathway, we have incorporated oleyl derivatives of methotrexate and floxuridine (FdUrd) into LDL particles. Three different incorporation procedures were studied: Method A, the dry film method; Method B, the transfer protein method; and Method C, the delipidation-reconstitution method. In all cases, 3H-labeled drug was incorporated into 125I-labeled LDL to yield double-labeled particles so that the behavior of both drug and carrier could be followed simultaneously. The last method led to the highest drug loading and it was possible to incorporate 50-70 molecules of dioleoyl-FdUrd per LDL particle as compared with about 18 molecules of drug when utilizing the transfer protein procedure. In vitro studies on the interaction of dioleoyl-FdUrd-LDL particles, obtained by the delipidation-reconstitution method, with the hepatocellular carcinoma cell line Hep G2, indicated that these reconstituted particles were equally effective in competing for LDL binding as native LDL. Moreover, drug delivery to Hep G2 cells occurred at the same rate as cellular association of the apolipoprotein B. In vivo studies on the fate of dioleoyl-FdUrd-LDL complexes in rats indicated that the serum decay was increased as compared with native LDL. The half-life of 6-9 min is, however, considerably prolonged as compared to the free drug (t1/2 less than 1 min). It is suggested that the 6-fold increased serum half-life of the drug-LDL complex accompanied by the possibly more specific tumor delivery may lead to an increased therapeutic effect.
PPAR: a therapeutic target in Parkinson’s disease (2008)

Parkinson's disease (PD) is a progressive and chronic neurodegenerative disorder, characterized by progressive loss of dopaminergic neurons in substantia nigra. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteosomal dysfunction in the pathogenesis of PD. Due to multifactorial nature of the disease, currently available drug therapy cannot halt / slow down the disease progression, and only provides symptomatic relief. Peroxisome proliferator-activated receptor (PPAR), a member of nuclear receptor superfamily, regulates development, tissue differentiation, inflammation, mitochondrial function, wound healing, lipid metabolism and glucose metabolism. Recently, several PPAR agonists were shown to exert neuroprotective activity against oxidative damage, inflammation and apoptosis in several neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis and multiple sclerosis. Similarly, regular intake of PPAR activating non-steroidal anti-inflammatory drugs such as indomethacin and ibuprofen was associated with reduced incidence and progression of neurodegenerative disorders in several epidemiological studies. In this article, we review studies relating to the neuroprotective effect of PPAR agonists in in vitro and in vivo models of PD. Similarly, the pharmacological mechanism in neuroprotective actions of PPAR agonists is also reviewed. In conclusion, PPAR agonists exert neuroprotective actions by regulating the expression of a set of genes involved in cell survival processes, and could be a therapeutic target in debilitating neurodegenerative illnesses such as PD.
Come-back of phenanthridine and phenanthridinium derivatives in the 21st century (2014)

Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds with efficient DNA binding capability. Attracting attention since DNA structure discovery (1960s), they were early recognized as a symbol of DNA intercalative binding, for many decades applied as gold-standard DNA- and RNA-fluorescent markers (ethidium bromide), probes for cell viability (propidium iodide), but also "ill-famed" for various toxic (genotoxic) and mutagenic effects. After two decades of low interest, the discovery of phenanthridine alkaloids and new studies of antiparasitic/antitumor properties of phenanthridine derivatives resulted in the strong increase of the scientific interest about the turn of this century. Here are summarized phenanthridine-related advances in the 21st century (2000-present period) with emphasis on the supramolecular interactions and bioorganic chemistry, as well as novel or improved synthetic approaches.