gebhart/patrepeval huggingface dataset:
EFFICACY OF FIBRINOLYTlC ENHANCEMENT WITH STANOZOLOL IN THE TREATMENT OF VENOUS INSUFFICIENCY (1991)

Pericapillary fibrin cuffs have been shown in patients with chronic venous insufficiency. It has been suggested that this fibrin deposition is responsible for an oxygen diffusion block, leading to local hypoxia and resulting in ulceration. Fibrinolysis is depressed in patients with venous insufficiency and therefore pharmacological enhancement of this factor might be expected to produce clinical improvement in this condition. Sixty patients with lipodermatoscelerosis were entered into a prospective, double-blind, placebo-controlled, randomized trial. Stanozolol 5 mg or a placebo tablet was given twice daily for 6 months. All patients were supplied with below knee German/Swiss specification class 2 graduated compression stockings. The area of lipodermatosclerosis was measured at monthly intervals and transcutaneous oxygen tension within the liposclerotic area was measured at 3-monthly intervals. The control group showed a mean reduction in area of lipodermatosclerosis of 14% (95% c.i.: -2.6-31%) compared with a 28% reduction in area in the active treatment group (95% c.i.: 5.3-46%). Transcutaneous oxygen measurements showed no change in either group. Side effects were significantly more common in the active treatment group (P less than 0.02, Chi-squared). Although fibrinolytic enhancement caused a reduction in area of lipodermatosclerosis, no evidence of any effect on a possible oxygen diffusion block was indicated.
Electro-Optical Co-Design to Minimize Power Consumption of a 32 GBd Optical IQ-Transmitter Using InP MZ-Modulators (2015)

This paper addresses the power reduction concepts of an electro-optical transmitter applicable for future small form factor modules such as CFP4. To satisfy the power restrictions of these standards, equations and detailed explanations of the relevant shares of overall power consumption are given. To improve the overall efficiency, an open collector driver realized in a SiGe technology with fT = 190 GHz and fmax = 200 GHz is proposed for driving an InP-based IQ MZ-modulator. This approach saves 30 % of the driver power and achieves an EVMrms of 8.7 % for a QPSK-Signal at 32 GBd. A detailed performance comparison to a structurally identical back terminated driver is presented. Further power reduction is demonstrated with a bias tee configuration for a single modulator. DPSK measurements show a very low power consumption of 290 mW at an EVMrms of 7.5 %. The presented bias tee solution simplifies the assembly without performance compromises. All drivers presented in this paper have differential input/output signals and were designed for a non 50 Ohm output impedance to optimize power consumption and performance.
Dynamic epimarks in sex-related genes predict gonad phenotype in the European sea bass, a fish with mixed genetic and environmental sex determination (2018)

The integration of genomic and environmental influences into methylation patterns to bring about a phenotype is of central interest in developmental epigenetics, but many details are still unclear. The sex ratios of the species used here, the European sea bass, are determined by genetic and temperature influences. We created four families from parents known to produce offspring with different sex ratios, exposed larvae to masculinizing temperatures and examined, in juvenile gonads, the DNA methylation of seven genes related to sexual development by a targeted sequencing approach. The genes most affected by both genetics and environment were cyp19a1a and dmrt1, with contrasting sex-specific methylation and temperature responses. The relationship between cyp19a1a methylation and expression is relevant to the epigenetic regulation of vertebrate sex, and we report the evidence of such relationship only below a methylation threshold, ~ 80%, and that it was sex-specific: negatively correlated in females but positively correlated in males. From parents to offspring, the methylation in gonads was midway between oocytes and sperm, with bias towards oocytes for amh-r2, er-β2, fsh-r and cyp19a1a. In contrast, dmrt1 levels resembled those of sperm. The methylation of individual CpGs from foxl2, er-β2 and nr3c1 were conserved from parents to offspring, whereas those of cyp19a1a, dmrt1 and amh-r2 were affected by temperature. Utilizing a machine-learning procedure based on the methylation levels of a selected set of CpGs, we present the first, to our knowledge, system based on epigenetic marks capable of predicting sex in an animal with ~ 90% accuracy and discuss possible applications.
Polycystic horseshoe kidney (2013)

A 32-year-old man was examined for primary infertility. Ultrasound and computed tomography (CT) abdomen scans showed the presence of polycystic horse shoe kidney (Figure 1). CT abdomen revealed cysts in liver and seminal vesicles (Figure 2). There were bilateral ureteric calculi. There were no cysts in the pancreas or spleen. His serum creatinine level was 0.9 mg/dL (79.6 mmol/L). The patient has a younger brother and a sister. Ultrasound abdomen of his father of age 62 years and mother of age 60 years did not reveal the presence of either horseshoe kidney or polycystic kidney. Polycystic horseshoe kidney is thought to represent two separate renal diseases. Horseshoe kidney is a renal fusion anomaly during embryogenesis; autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder due to mutations in the genes responsible for the expression of the proteins polycystin 1 (ADPKD1) and polycystin 2 (ADPKD2). Horseshoe kidney occurs in one per 400–800 live births and ADPKD in one per 400–1000 live births. Polycystic horseshoe kidney occurs 1 in 134 000 to 1 in 8 000 000 live births [1]. To date, no genetic association has been described between the ADPKD loci (PKD1 on chromosome 16 and PKD2 on chromosome 4) and horseshoe kidneys. Necrospermia or low sperm motility with a high proportion of dead sperm, ultrastructural flagellar defect, immotile sperm and seminal vesicular and ejaculatory cysts are reported to be causes of infertility in male ADPKD patients [2]. The reported prevalence of seminal vesicle cysts was 39% [3] to 43.47% [4]. The cysts of seminal vesicles in ADPKD are due to pathological dilation of the normally tortuous vesicles. The infertility is not due to obstruction, but a failure to propel the contents of seminal vesicles (Figure 3).
Design of an RF-subsampling based tri-band AIS and DSC radio receiver (2009)

This paper proposes the design of a tri-band AIS1, AIS2 and DSC VHF receiver. Original highly integrated and single path RF front-end is defined by replacing conventional analog mixers with a sample and hold circuit for frequency downconversion. Detailed system level design based on RF-subsampling theory allowed the choice of an optimized sampling frequency of 48.93 MHz for the three radio bands by considering anti-aliasing and noises constraints. The receiver design is based on commercial components with relaxed characteristics. Simulation results with ADS models for selected components shows good performances with an SNR degradation of 7 dB.
Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes. (1990)

Murine melanoma B16-F1 cells of low metastatic potential were transfected with the human gene for the prepro form of urokinase in an SV40 expression vector (plasmid pSV2-uPA), and cells expressing high amounts of the human urokinase gene product were selected for by an enzyme-linked immunosorbent assay specific for human high molecular weight urokinase. Southern analysis showed one of the cell lines (clone 7) had incorporated 150 copies of the pSV2-uPA plasmid into its genomic DNA. The human urokinase synthesized by the pSV2-uPA-transfected murine B16 cells was found to be glycosylated and did not bind to the murine cell surface urokinase receptor sites. In an in vivo assay that measures metastasis from a primary tumor (spontaneous metastatic assay), clone 7 cells showed an increased ability to metastasize (12 of 12 mice showed metastatic tumors), while control cells showed a lower ability to metastasize (only 2 of 11 mice showed metastatic tumors). In a second in vivo assay, which measures only the steps of the metastatic migration process during which tumor cells extravasate from the blood and then grow into pulmonary tumors (lung colonization assay), a significant multifold increase in the ability to form lung tumors was shown by the high human urokinase-secreting B16-F1 cells. In B16-F10 cells incorporating an antisense sequence to preprourokinase (plasmid pSV1-ASuPA-265) and secreting significantly decreased amounts of murine urokinase, a corresponding significant decrease in lung colonization was observed. These results provide direct experimental support for a role of secreted (non-surface-bound) urokinase in the colonization steps of the metastatic process. Furthermore, the data indicate that the higher lung colonization ability of the B16-F10 line than of the B16-F1 line is primarily based on the quantitative differences in their abilities to produce urokinase.
Phytohemagglutinins. Their nutritional significance (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhytohemagglutinins. Their nutritional significanceIrvin E. LienerCite this: J. Agric. Food Chem. 1974, 22, 1, 17–22Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/jf60191a031https://doi.org/10.1021/jf60191a031research-articleACS PublicationsRequest reuse permissionsArticle Views252Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation of DNA from Forensic Evidence (2000)

This unit covers the many and varied methods for extracting DNA from such diverse specimens as blood, tissue, stamps and envelopes, and cigarette butts, among others. Modifications to the methods that allow the DNA to be used for either PCR or Southern blotbased analyses are also included.
Method of estimating the state of charge of a battery electric vehicle based on RS-SVM (2015)

Charging, discharge, maintenance and energy management technology for electric vehicle power battery is relatively backward, An advanced and reasonable method is presented for battery state of charge( SOC ), used simple rough set attribute ,simplified battery charging related parameters, the simplified data is processed by using the support vector machine (SVM) to predict charged state of the battery , and the service life of the battery is lengthened .This paper has important research value.
Response Time Effort: A New Measure of Examinee Motivation in Computer-Based Tests (2005)

Abstract When low-stakes assessments are administered, the degree to which examinees give their best effort is often unclear, complicating the validity and interpretation of the resulting test scores. This study introduces a new method, based on item response time, for measuring examinee test-taking effort on computer-based test items. This measure, termed response time effort (RTE), is based on the hypothesis that when administered an item, unmotivated examinees will answer too quickly (i.e., before they have time to read and fully consider the item). Psychometric characteristics of RTE scores were empirically investigated and supportive evidence for score reliability and validity was found. Potential applications of RTE scores and their implications are discussed.
Measuring Liveable Wage Job Openings: A Look at Maine Data for 1993-94 (1996)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
X-ray Absorption Spectroscopy of an Investigational Anticancer Gallium(III) Drug: Interaction with Serum Proteins, Elemental Distribution Pattern, and Coordination of the Compound in Tissue (2012)

Tris(8-quinolinolato)gallium(III) (1, KP46) is a very promising investigational anticancer drug. Its interaction with serum proteins, elemental distribution, and coordination in tissue were investigated with X-ray absorption (XAS) methods. Model compounds with mixed O, N, and/or S donor atoms are reported. The coordination and structure of 1 in cell culture medium (minimum essential medium, MEM) and fetal calf serum (FCS) were probed by XANES and EXAFS. The interaction of 1 with the serum proteins apotransferrin (apoTf) and human serum albumin (HSA) was addressed as well. By application of micro-XAS to tissue samples from mice treated with 1, the gallium distribution pattern was analyzed and compared to those of physiological trace elements. The complex 1 turned out to be very stable under physiological conditions, in cell culture media and in tissue samples. The coordination environment of the metal center remains intact in the presence of apoTf and HSA. The gallium distribution pattern in tumor and liver tissue revealed high similarities to the distribution patterns of Zn and Fe, minor similarities to Cu and Ni, and no similarity to Ca.
Cell Type- and Promoter-specific Roles of Ser18 Phosphorylation in Regulating p53 Responses (2003)

Phosphorylation of mouse p53 at Ser18 occurs after DNA damage. To determine the physiological roles of this phosphorylation event in p53-dependent DNA damage responses, a Ser18 to Ala missense mutation was introduced into the germline of mice. Thymocytes and fibroblasts from the knock-in mice show reduced transactivation of many p53 target genes following DNA damage. p53 protein stabilization and DNA binding are similar in knock-in and wild type mice, but C-terminal acetylation was defective, consistent with a role for Ser18 in the recruitment of transcriptional co-activators. The apoptotic response of knock-in thymocytes to ionizing radiation is intermediate between that of wild type and p53 null thymocytes. Despite impaired transcriptional and apoptotic responses, the knock-in mice are not prone to spontaneous tumorigenesis. This indicates that neither phosphorylation of p53 on Ser18 by ATM nor a full transcriptional response is essential to prevent spontaneous tumor formation in mice.
Label-Free CMOS DNA Quantification with On-Chip Noise Reduction Schemes (2007)

We present a label-free CMOS DNA sensor with a new sensing-pixel architecture and background noise reduction scheme. The proposed sensor generates a differential signal between bio-samples and reference buffer solution with significant reduction in offset and gain fixed pattern noise by employing on-chip correlated double sampling circuits. Non-surface-binding detection technique allows to quantify DNA molecules continuously and sequentially and to reuse the sensor by simple washing protocol. By directly reading the negative charges of DNA molecules, DNA concentrations from 1μM to 10μM have been successfully discriminated.
Hydroxyureas as Noncovalent Proteasome Inhibitors (2011)

Inhibitors with a new mechanism of action are needed for 20S proteasome (CP) inhibition owing to the ineffectiveness of current market drugs against some types of solid tumors. A novel class of nonpeptidic CP inhibitors has been developed, which display reversible and noncovalent binding. The structure-based design of these highly active and site-specific inhibitors revealed unexplored binding subpockets. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Reading as reasoning: A study of mistakes in paragraph reading. (1917)

It seems to be a common opinion that reading (understanding the meaning of printed words) is a rather simple compounding of habits. Each word or phrase is supposed, if known to the reader, to call up its sound and meaning and the series of word or phrase meanings is supposed to be, or be easily transmuted into, the total thought. It is perhaps more exact to say that little attention has been paid to the dynamics whereby a series of words whose meanings are known singly produces knowledge of the meaning of a sentence or paragraph. It will be the aim of this article to show that reading is a very elaborate procedure, involving a weighing of each of many elements in a sentence, their organization in the proper relations one to another, the selection of certain of their connotations and the rejection of others, and the cooperation of many forces to determine final response. In fact we shall find that the act of answering simple questions about a simple paragraph like the one shown below includes all the features characteristic of typical reasonings.
Modern Acetylene Chemistry (1995)

Part 1 Modern computational and theoretical aspects of acetylene chemistry, Dietmar A. Plattner et al: electronic structures of acetylene and monoacetylenes reactivities and molecular interactions of acetylenes polyacetylenes. Part 2 Functionalized acetylenes in organic synthesis - the cases of the 1-cyano- and the 1-halogenacetylenes, Henning Hopf and Bernhard Witulski: synthesis and preparative use of cyanoacetylenes synthesis and preparative use of 1-halogenacetylenes experimental procedures. Part 3 Alkynyliodonium salts - electrophilic acetylene equivalents, Peter J. Stang: preparation and properties characterization and structure reactions and uses of alkynyliodonium salts experimental procedures. Part 4 The chemistry of metal-alkyne complexes, Gagik G. Melikyan and Kenneth M. Nicholas: bonding and structure complexes of novel alkynes reactions of metal-alkyne complexes special applications of metal-alkyne complexes selected experimental procedures. Part 5 Organometallic cycloaddition reactions of acetylenes, Joseph A. Casalnuovo and Neil E. Schore: cycloadditions of acetylenes with Fischer carbenes the Pauson-Khand reaction - cycloadditions of olefins, acetylenes and CO. Part 6 Phosphaalkynes - starting point for the synthesis of phosphorous-carbon cage compounds, Manfred Regitz et al: syntheses of phosphaalkynes reactivity of phosphaalkynes the history of phosphorous-carbon cage compounds from phosphaalkynes synthesis of phosphorous-carbon cage compounds outlook experimental procedures. Part 7 The enediyne antibiotics, K.C. Nicolaou and Adrian L. Smith: the aromaticity era the discovery of the enediyne antibiotics theoretical and synthetic studies on the enediyne antibiotics medical applications of the enediyne antibiotics. Part 8 Cyclic alkynes - preparation and properties, Rolf Gleiter and Roland Merger: synthesis of cyclic acetylenes structural and spectroscopic properties organic reactions of cyclic alkynes reactions of cyclic alkynes with metal compounds experimental procedures. Part 9 Macrocyclic homoconjugated polyacetylenes, Lawrence T. Scott and Mark J. Cooney: pericyclynes exploded pericyclynes homoconjugated mixed polyalkyne/diyne macrocycles heterocyclic cognates of pericyclynes experimental procedures. Part 10 Polyacetylene, Eric J. Ginsburg et al: syntheses and properties. Part 11 Acetylenic compounds as building blocks for high-spin molecules and molecular assemblies, Hiizu Iwamura and Kenji Matsuda: alkynyl compounds carrying unpaired electrons molecular crystals of organic free radicals that carry alkynyl substituents spin alignments in poly(phenylacetylenes) and poly(1,3-butadiynes) cyclotrimerization reaction of benzoylacetylenes in the presence of a secondary amine experimental procedures. Part 12 Acetylenes in nanostructures, James K. Young and Jeffrey S. Moore: phenylacetylene dendrimers phenylacetylene macrocycles synthesis of sequence-(Part contents)
Lipid-Lowering Therapy in Low-Risk Patients (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases. (1997)

Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor found in fluids lining mucosal surfaces. In addition to its primary function as an antiprotease, SLPI may also influence cellular functions associated with enzyme synthesis and retroviral infection. In this study, SLPI was examined for its effect on signaling events involved in the production of matrix metalloproteinases (MMPs) by monocytes. Addition of SLPI before stimulation with concanavalin A or LPS resulted in a significant inhibition of monocyte prostaglandin H synthase-2 (PGHS-2), a pivotal enzyme in the PGE2-cAMP dependent pathway of monocyte MMP synthesis. Suppression of PGHS-2 was detected with 0.1 microg/ml of SLPI with a substantial inhibition at 1 and 10 micro/ml. Attenuation of PGHS-2 by SLPI was accompanied by decreased production of PGE2 resulting in the suppression of interstitial collagenase (MMP-1) and gelatinase B (MMP-9) that was reversed by PGE2 or Bt2cAMP. The inhibitory effect of SLPI was largely independent of its antiprotease activity because SLPI muteins, with significantly lower antiprotease activity, also suppressed the induction of PGHS-2 and MMPs. The inhibitory effects of SLPI did not involve the modulation of monokine production since TNF-alpha and IL-10 were unaffected. These findings demonstrate that SLPI also functions as a potent antiinflammatory agent by interfering with the signal transduction pathway leading to monocyte MMP production.