gebhart/patrepeval huggingface dataset:
PP.04.19 (2015)

Objective: The aim was to examine the correlation between non-invasive parameters and outcomes in patients (pts) with essential arterial hypertension (AH) and left ventricular hypertrophy (LVH) during the twelve years of follow-up. Design and method: All 104 pts with AH and LVH (55.3 ± 8.4 years; 61 male and 43 female) were examined by means of echocardiography (two independent examiners - Acuson-Sequoia), exercise testing, 24-h Holter monitoring, 24-h ambulatory blood pressure monitoring, heart rate variability and QTc interval dispersion. Patients used regular medicament therapy during the period of follow-up. Results: During the twelve years period of follow-up in 31 (29.8%) pts occurred cardiovascular and cerebrovascular adverse events (AE). At the beginning of the study pts with AE had greater: LVMI (190.4 ± 38.0 g/m2 vs. 162.5 ± 25.2 g/m2; p < 0.001), left ventricular mass (367.2 ± 85.0 g vs. 320.2 ± 63.9 g; p < 0.01), septum thickness (14.5 ± 3.0 mm vs. 13.2 ± 2.0 mm; p < 0.05), posterior wall thickness (12.1 ± 1.3 mm vs. 11.6 ± 1.0 mm; p < 0.05) and left atrial diameter (41.5 ± 6.2 mm vs. 39.0 ± 4.5 mm; p < 0.05). In pts with AE QTc dispersion was greater than in pts without AE (73.1 ± 19.7 ms vs. 54.0 ± 19.6 ms; p < 0.001). AE occurred in 20 (52.6%) pts of 38 pts with QTc dispersion greater than 65 ms and in 11 (16.7%) pts of 66 pts with QTc dispersion lower than 65 ms (odds ratio 5.56; 95% CI 2.24 to 13.77). Using multiple linear regression analysis the best predictors of worse prognosis were QTc dispersion and LVMI (standardized coefficient beta: for QTc dispersion 0.380; p < 0.001 and for LVMI 0.370; p < 0.001 and for the model: R = 0.551, R2 = 0.303, adjusted R2 = 0.290, standard error of the estimate = 0.38743; p < 0.001). Conclusions: Patients with greater QTc dispersion, especially greater than 65 ms, and greater left ventricular mass index have worse outcome during the twelve years in spite of regular medical treatment.
Microwave receivers using SQUIDs and Josephson junction arrays (1981)

Performance of various microwave receiving devices, using the Josephson junctions closed with superconducting loops and/or united in arrays, is discussed. These composite nonlinear elements enable us to eliminate problem of their matching with the signal source, to increase the saturation power and to come close to ultimate limits of the device noise performance. For internally-pumped devices, connection of several junctions in a closed-loop (ring) array turns out to be most effective, with coherent junction self-oscillations. For externally-pumped devices, the use of low-inductance (non-hysteretic) SQUIDs is of the greatest interest, enabling one to avoid the difference in junction dynamics due to parameter random spread.
Carrier Differential GPS for Takeoff to Landing of an Autonomous Aircraft (1996)

Using the carrier phase of the GPS signal, one is able
to resolve relative displacements in space to the cen-
timeter level. This paper describes the use of carrier
differential techniques to determine the position, ve-
locity, attitude and angular velocity of an autonomous
aircraft in real time. The full state GPS estimates are
used in linear quadratic (LQ) feedback control to auto-
mate the flight of the aircraft from takeoff thru landing.
We present Ilight data from recent flight tests. In ad-
dition to GPS, the aircraft is instrumented with a vari-
ety of inexpensive conventional sensors including alpha
and beta vanes, and a dynamic pressure sensor (pitot).
These provide an independent measurement of the air-
craft velocity relative to the air. This independent mea-
surement enables estimation of the the absolute wind
vector, which is used in waypoint tracking.
Prioritized Distributed Video Delivery With Randomized Network Coding (2011)

We address the problem of prioritized video streaming over lossy overlay networks. We propose to exploit network path diversity via a novel randomized network coding (RNC) approach that provides unequal error protection (UEP) to the packets conveying the video content. We design a distributed receiver-driven streaming solution, where a client requests packets from the different priority classes from its neighbors in the overlay. Based on the received requests, a node in turn forwards combinations of the selected packets to the requesting peers. Choosing a network coding strategy at every node can be cast as an optimization problem that determines the rate allocation between the different packet classes such that the average distortion at the requesting peer is minimized. As the optimization problem has log-concavity properties, it can be solved with low complexity by an iterative algorithm. Our simulation results demonstrate that the proposed scheme respects the relative priorities of the different packet classes and achieves a graceful quality adaptation to network resource constraints. Therefore, our scheme substantially outperforms reference schemes such as baseline network coding techniques as well as solutions that employ rateless codes with built-in UEP properties. The performance evaluation provides additional evidence of the substantial robustness of the proposed scheme in a variety of transmission scenarios.
Hydrogen Peroxide Propulsion for Smaller Satellites (2025)

As satellite designs shrink, providing maneuvering and control capability falls outside the realm of available propulsion technology. While cold gas has been used on the smallest satellites, hydrogen peroxide propellant is suggested as the next step in performance and cost before hydrazine. Minimal toxicity and a small scale enable bench top propellant preparation and development testing. Progress toward low-cost thrusters and self-pressurizing tank systems is described.
Improved Retroviral Vectors for Hematopoietic Stem Cell Protection and <i>In Vivo</i> Selection (1996)

Therapeutic gene transfer into hematopoietic cells is critically dependent on the evolution of methods that allow ex vivo expansion, high-frequency transduction, and selection of gene-modified long-term repopulating cells. Progress in this area needs elaboration of defined culture and transduction conditions for long-term repopulating cells and improvement of gene transfer systems. We have optimized retroviral vector constructions based on murine leukemia viruses (MuLV) to overcome the transcriptional repression encountered with the use of conventional Moloney MuLV (MoMuLV) vectors in early hematopoietic progenitor cells (HPC). Novel retroviral vectors, termed FMEV (for Friend-MCF/MESV hybrid vectors), were cloned that mediate greatly improved gene expression in the myeloerythroid compartment. Transfer of the selectable marker multidrug resistance 1 (mdr1), FMEV, in contrast to conventional MoMuLV-related vectors currently in use for clinical protocols, mediated background-free selectability of transduced human HPC in the presence of myeloablative doses of the cytostatic agent paclitaxel in vitro. Furthermore, FMEV also greatly improved chemo-protection of hematopoietic progenitor cells in a murine model system in vivo. Finally, when a second gene was transferred along with mdr1 in an FMEV-backbone, close to 100% coexpression was observed in multidrug-resistant colonies. These observations have significant consequences for a number of ongoing and planned gene therapy trials, for example, stem cell protection to reduce the myelotoxic side effects of anticancer chemotherapy, correction of inherited disorders involving hematopoietic cells, and antagonism of HIV infection.
A Modified Procedure for the Synthesis of 5-Amino-3-arylisoxazoles and Their Reactions with Tetrasulfur Tetranitride Antimony(V) Chloride Complex (S4N4ÅESbCl5) : Novel Synthesis of 3-Aryl-1,2,5-thiadiazole-4-carboxamides (2001)

Dropwise addition of a-bromo ketoximes to a solution of KCN in MeOH at room temperature gave 5-amino-3-arylisoxazoles in moderate to good yields.Treatment of the isoxazoles prepared with tetrasulfur tetranitride antimony (V) chloride complex (S 4 N 4 •SbCl 5 ) in toluene at 100°C afforded novel 3-aryl-1,2,5-thiadiazole-4-carboxamides.Isoxazoles are an important class of heterocyclic compounds and their chemistry has been extensively studied. 1 Recently we have shown that treatment of 3-alkyl-5-aryl-and 3,5-diarylisoxazoles (1) with tetrasulfur tetranitride antimony(V) chloride complex (S 4 N 4 •SbCl 5 ) (2) in toluene at reflux gave 3-alkyl-4aroyl-and 3-aroyl-4-aryl-1,2,5-thiadiazoles (3), 2 whereas compounds (1) did not react with tetrasulfur tetranitride (S 4 N 4 ) (4) under the same conditions with quantitative recovery of 1 (Scheme 1).
ASBMR 29th Annual Meeting (2007)

Transient receptor potential (TRP) cation channels are currently drawing a lot of interest in many tissues, but relatively little interest in bone. TRP channels are mostly non-selective and are generally widely expressed with increased expression in some malignancies1, and TRPV1 and TRPM8 ligands, for example, may have potential uses as anti-cancer agents2 in prostate malignancy. As prostate cancer cells metastasize to and cohabit with bone cells, this area of research is potentially important and deserves attention. The putative roles of TRP channels include growth, repair, metastasis, apoptosis and cell calcium entry — all of which are relevant to osteoblasts. We aim to show that TRP channels are present and active in osteoblast-like cells. RT-PCR was carried out using intron-spanning primer pairs for TRPV1, TRPV5, TRPV6, TRPM7 and TRPM8 subunits in MG63 and SaOS-2 osteoblast-like cells. Cell proliferation assays were performed over 72 hours to test the effects of known TRP ligands on cell number, using trypan blue exclusion testing and MTS-conversion assay. Patch-clamp analysis was performed on MG63 and SaOS-2 cells using calcium-free and/or sodium gluconate solutions to minimise the confounding influence of other channel subtypes. RT-PCR has revealed appropriate sized bands for TRPV1, TRPV5, TRPV6, TRPM7 and TRPM8 in MG63 and SaOS-2 cell lines. In cell proliferation assays, > 10 μM capsaicin or capsazepine significantly reduced MG63 cell number (P < 0.05), but 1 μM capsazepine antagonises the effects of > 10 μM capsaicin. In addition, resiniferatoxin (TRPV1 agonist), SB366791 (TRPV1 blocker) and anandamide (cannabinoid and TRPV1 modulator) all decreased MG63 cell numbers. Patch-clamp analysis has revealed small conductance channels of 18 — 30 pS in excised inside-out patches, and slightly larger conductance channels in cell-attached and inside-out patches at depolarised and hyperpolarised potentials in MG63 and LNCaP (prostate cancer) cells. Given our preliminary data, we propose that five members of the TRP channel family are expressed in osteoblast-like cell lines, and we show electrophysiological and pharmacological data which lead us to suggest that at least one TRP channel type is active and functional in bone. TRP channels could therefore be new targets in the battle against bone disorders, and some known TRP channel ligands could be included in that armoury.
Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-<i>N</i>- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1<i>H</i>-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor (2003)

Factor Xa, a serine protease, is at the critical juncture between the intrinsic and extrinsic pathways of the coagulation cascade. Inhibition of factor Xa has the potential to provide effective treatment for both venous and arterial thrombosis. We recently described a series of meta-substituted phenylpyrazoles that are highly potent, selective, and orally bioavailable factor Xa inhibitors. In this paper we report our efforts to further optimize the selectivity profile of our factor Xa inhibitors with a series of ortho- and/or para-substituted phenylpyrazole derivatives. The most potent compounds display sub-nanomolar inhibition constants for factor Xa and show greater than 1000-fold selectivity against other serine proteases. These compounds are also effective in a rabbit model of arteriovenous shunt thrombosis. Optimization of this series led to the preclinical development of DPC602, a 2-(aminomethyl)phenylpyrazole analogue, as a highly potent, selective, and orally bioavailable factor Xa inhibitor.
On Understanding Translation Practice (2009)

This paper discusses the concept of translation practice and points out different people have different ideas about it. In translation practice, a lot of knowledge is waiting for a person who wants to be a translator.
vi Editor Pocket Reference (1999)

From the Publisher:
For many users, working in the UNIX environment means using vi, a full-screen text editor available on most UNIX systems. Even those who know vi often make use of only a small number of its features. 
The vi Editor Pocket Reference is a companion volume to O'Reilly's newly updated sixth edition of Learning the vi Editor, a complete guide to text editing with vi. New topics in Learning the vi Editor include multi-screen editing and coverage of four vi clones: vim, elvis, nvi, and vile. 
This small book is a handy reference guide to the information in the larger volume, presenting movement and editing commands, the command-line options, and other elements of the vi editor in an easy-to-use tabular format.
Integrating active information delivery and reuse repository systems (2000)

Although software reuse can improve both the quality and productivity of software development, it will not do so until software developers stop believing that it is not worth their effort to find a component matching their current problem. In addition, if the developers do not anticipate the existence of a given component, they will not even make an effort to find it in the first place. Even the most sophisticated and powerful reuse repositories will not be effective if developers don't anticipate a certain component exists, or don't deem it worthwhile to seek for it. We argue that this crucial barrier to reuse is overcome by integrating active information delivery , which presents information without explicit queries from the user, and reuse repository systems. A prototype system, CodeBroker , illustrates this integration and raises several issues related to software reuse.
Fecal neutrophil gelatinase‐associated lipocalin as a biomarker for inflammatory bowel disease (2016)

Fecal NGAL is a promising biomarker for IBD. As existing biomarkers are expressed mainly in granulocytes, NGAL's epithelial localization may give supplementary diagnostic information.
Essential Tyrosine Residues for Interaction of the Non-receptor Protein-tyrosine Phosphatase PTP1B with N-cadherin (2001)

Expression of a dominant-negative, catalytically inactive form of the nonreceptor protein-tyrosine phosphatase PTP1B in L-cells constitutively expressing N-cadherin results in loss of N-cadherin-mediated cell-cell adhesion. PTP1B interacts directly with the cytoplasmic domain of N-cadherin, and this association is regulated by phosphorylation of tyrosine residues in PTP1B. The following three tyrosine residues in PTP1B are potential substrates for tyrosine kinases: Tyr-66, Tyr-152, and Tyr-153. To determine the tyrosine residue(s) that are crucial for the cadherin-PTP1B interaction we used site-directed mutagenesis to create catalytically inactive PTP1B constructs bearing additional single, double, or triple mutations in which tyrosine was substituted by phenylalanine. Mutation Y152F eliminates binding to N-cadherin in vitro, whereas mutations Y66F and Y153F do not. Overexpression of the catalytically inactive PTP1B with the Y152F mutation in L-cells constitutively expressing N-cadherin has no effect on N-cadherin-mediated adhesion, and immunoprecipitation reveals that the mutant Y152F PTP1B does not associate with N-cadherin in situ. Furthermore, among cells overexpressing the Y152F mutant endogenous PTP1B associates with N-cadherin and is tyrosine-phosphorylated.
Complication and failure rates after corneal crosslinking (2009)

Results indicate that changing the inclusion criteria may significantly reduce the complications and failures of CXL. A preoperative maximum K reading less than 58.00 diopters may reduce the failure rate to less than 3%, and restricting patient age to younger than 35 years may reduce the complication rate to 1%.
Synthetic Study on Human C-Peptide and its Related Peptides (1981)

Syntheses of eighteen peptides related to human C-peptide and the connecting peptide are described. The syntheses were performed exclusively by the azide fragment condensation method. The immunochemical results justified the utilization of these peptides for development of human C-peptide radioimmunoassay system. The synthetic peptide fragments may be extremely important substrates for assessment of specificity of human C-peptide antisera and thus usefulness of the antisera in practical measurement of blood levels of human C-peptide immunoreactivity.
Junction Transistor Equivalent Circuits and Vacuum-Tube Analogy (1952)

The junction transistor possesses operating characteristics that are closely comparable to a modified triode vacuum tube. A direct comparison between the two devices is particularly interesting if a π equivalent circuit is used for the transistor. The vacuum-tube analogy and transistor equivalent circuits are considered in some detail in this paper. For purposes of comparison, a tabulation of operating characteristics of a transistor and a vacuum tube has been prepared.
Yakov Malkiel, Etymology. Cambridge: Cambridge University Press, 1993. Pp. xii + 223. (1994)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Urinary tract infections in pregnant women with bacterial vaginosis (2007)

Urinary tract infections (UTIs) and bacterial vaginosis are common problems in pregnancy and are associated with serious obstetric complications. We evaluated the risk of UTIs in pregnant women with bacterial vaginosis. A total of 322 pregnant women who presented for a prenatal visit were evaluated for bacterial vaginosis and UTIs, between March 2003 and September 2004. Bacterial vaginosis was diagnosed based on Amsel's criteria. Women using antibiotic or other vaginal cream, with specific vaginitis or vaginal bleeding were excluded. Data were analysed using chi(2), Student t-test and multiple logistic regression. A total of 76 women had bacterial vaginosis and 246 women did not; and 18 women (23.6%) with bacterial vaginosis had UTIs, compared with 24 (9.8%) of those without. Bacterial vaginosis was associated with an increased risk of UTIs (odds ratio (OR) 3.05; 95% CI: 1.47-6.33). Pregnant women with bacterial vaginosis are at increased risk for UTIs.
New Tetrapolar Method for Complex Bioimpedance Measurement (2014)

Complex bioimpedance measurement is an important key which enables to characterize the state of tissues and organs. Body fat content, tissue ischemia, skin hydration are some different areas where it is widely used. As compared to conventional methods, new tetrapolar method has been investigated to calculate the bioimpedance based on magnitude ratio and phase difference detection technique. Low power consumption, low cost and its simpler design make it more popular and efficient technique than traditional bioimpedance measuring system.
Substituent Effects on the Stereospecificity of Propylene Polymerization by Novel Asymmetric Bridged Zirconocenes. A Mechanistic Discussion (2000)

The synthesis and polymerization behavior of a new C1-symmetric bridged indenyl−fluorenyl zirconocene dimethylsilylene [9-fluorenyl][(2,4,7-trimethyl)indenyl]zirconium dichloride (5) is reported. The complex when activated by MAO was found to polymerize ethylene and propylene, although the activity and stereoselectivity of 5 for propylene were found to be lower than for the previously prepared ethylene-bridged analogue 4 and several other ethylene-bridged precursors. It has been found that, depending on both the substitution patterns on the indenyl ligand and the nature of the bridge in this series of asymmetric zirconocenes, polypropylenes with varying microstructures from aspecific to highly isospecific are obtained. The propylene polymerization behavior of the new complexes has been studied in detail, and the mechanistic aspects of polymerization are discussed.
Yes-Associated Protein 65 (YAP) Expands Neural Progenitors and Regulates Pax3 Expression in the Neural Plate Border Zone (2011)

Yes-associated protein 65 (YAP) contains multiple protein-protein interaction domains and functions as both a transcriptional co-activator and as a scaffolding protein. Mouse embryos lacking YAP did not survive past embryonic day 8.5 and showed signs of defective yolk sac vasculogenesis, chorioallantoic fusion, and anterior-posterior (A-P) axis elongation. Given that the YAP knockout mouse defects might be due in part to nutritional deficiencies, we sought to better characterize a role for YAP during early development using embryos that develop externally. YAP morpholino (MO)-mediated loss-of-function in both frog and fish resulted in incomplete epiboly at gastrulation and impaired axis formation, similar to the mouse phenotype. In frog, germ layer specific genes were expressed, but they were temporally delayed. YAP MO-mediated partial knockdown in frog allowed a shortened axis to form. YAP gain-of-function in Xenopus expanded the progenitor populations in the neural plate (sox2(+)) and neural plate border zone (pax3(+)), while inhibiting the expression of later markers of tissues derived from the neural plate border zone (neural crest, pre-placodal ectoderm, hatching gland), as well as epidermis and somitic muscle. YAP directly regulates pax3 expression via association with TEAD1 (N-TEF) at a highly conserved, previously undescribed, TEAD-binding site within the 5' regulatory region of pax3. Structure/function analyses revealed that the PDZ-binding motif of YAP contributes to the inhibition of epidermal and somitic muscle differentiation, but a complete, intact YAP protein is required for expansion of the neural plate and neural plate border zone progenitor pools. These results provide a thorough analysis of YAP mediated gene expression changes in loss- and gain-of-function experiments. Furthermore, this is the first report to use YAP structure-function analyzes to determine which portion of YAP is involved in specific gene expression changes and the first to show direct in vivo evidence of YAP's role in regulating pax3 neural crest expression.
Porphyrin based porous organic polymers: novel synthetic strategy and exceptionally high CO<sub>2</sub>adsorption capacity (2011)

Iron containing porous organic polymers (Fe-POPs) have been synthesized by a facile one-pot bottom-up approach to porphyrin chemistry by an extended aromatic substitution reaction between pyrrole and aromatic dialdehydes in the presence of small amount of Fe(III). The Fe-POPs possess very high BET surface area, large micropores and showed excellent CO(2) capture (~19 wt%) at 273 K/1 bar.
[Study on the inclusion interaction of beta-cyclodextrin with phosphatidylcholine by UV spectra]. (2001)

A kind of cyclic oligosaccharides, beta-cyclodextrin (beta-CD) was found to possess inclusion ability with phosphatidylcholine (PC). The inclusion compound of beta-CD with PC was studied by elemental analysis of solid inclusion compound and UV spectra of different mole ratios beta-CD/PC in H2O-MeOH solution. The results indicate that two moles of beta-CD include one mole PC to form inclusion compound by Van Der Waals force, hydrophobic interaction and hydrogen bounds, etc. The selective binding ability of beta-CD with PC has been discussed from the viewpoint of size/shape-fitting and geometry fitting between the host cavity and the gust molecular. The solubility in aqueous solution, the oxidation stability of PC was increased by inclusion with beta-CD.