gebhart/patrepeval huggingface dataset:
[Age-dependent enzymatic changes in human cerebral cortex (author's transl)]. (1978)

Little information about the possible neurochemical-enzymatic changes occuring during aging of human brain is available. We, therefore, investigated the activity of various enzymes of human brains obtained at autopsy and covering a range from 19 to 91 years. Protein kinase, which mediates the information carried by the second messenger cAMP, does not show age-related changes of basal activity. Cyclic AMP-dependent activation of protein kinase remains nearly constant up to 60 years of life, but undergoes a distinct and progressive decline between 60 and 90 years. In corpus striatum no age-related changes of cyclic AMP-dependent protein kinase activity were observed. The activity of carbonic anhydrase demonstrates in both human cortex and corpus striatum an age-dependent decrease which also begins after the 6th decade of life. These neurochemical changes are similar to morphological and physiological changes occuring in the aging brain. They begin after the 60th year of life.
Atom Probe Tomographic Studies of Precipitation in Al-0.1Zr-0.1Ti (at.%) Alloys (2007)

Atom probe tomography was utilized to measure directly the chemical compositions of Al(3)(Zr(1)-(x)Ti(x)) precipitates with a metastable L1(2) structure formed in Al-0.1Zr-0.1Ti (at.%) alloys upon aging at 375 degrees C or 425 degrees C. The alloys exhibit an inhomogeneous distribution of Al(3)(Zr(1)-(x)Ti(x)) precipitates, as a result of a nonuniform dendritic distribution of solute atoms after casting. At these aging temperatures, the Zr:Ti atomic ratio in the precipitates is about 10 and 5, respectively, indicating that Ti remains mainly in solid solution rather than partitioning to the Al(3)(Zr(1)-(x)Ti(x)) precipitates. This is interpreted as being due to the very small diffusivity of Ti in alpha-Al, consistent with prior studies on Al-Sc-Ti and Al-Sc-Zr alloys, where the slower diffusing Zr and Ti atoms make up a small fraction of the Al(3)(Zr(1)-(x)Ti(x)) precipitates. Unlike those alloys, however, the present Al-Zr-Ti alloys exhibit no interfacial segregation of Ti at the matrix/precipitate heterophase interface, a result that may be affected by a significant disparity in the evaporation fields of the alpha-Al matrix and Al(3)(Zr(1)-(x)Ti(x)) precipitates and/or a lack of local thermodynamic equilibrium at the interface.
An Air-Drying Method for Chromosome Preparations from Mouse Eggs (1966)

The eggs, after being washed out from the genital tract, are put into hypotonic (1%) sodium citrate and left to stand at room temperature for 5–15 minutes. The duration of treatment is not very critical, but later stages, especially blastocysts, need longer treatment. A microdrop of this solution together with the eggs is placed on a grease-free slide. A few drops of acetic alcohol (3 parts of absolute ethyl alcohol, 1 part of glacial acetic acid) are immediately expelled from another pipette, whose tip is brought just over the microdrop containing eggs. The optimal number of drops of fixative has been found to be three in the case of eggs from the one cell to eight cell stage and five or even more in the case of blastocysts. These indications were calculated for drops measuring approximately 0.02 ml in volume. Air-dried preparations are stained in lactic-acetic-orcein or in 2% aqueous solution of toluidine blue. The method can be applied to all stages from diakinesis of the first meiotic division to blastocyst. It enables one to obtain excellent scattering of nuclei and metaphase plates and good spreading of chromosomes. The remnants of cytoplasm are negligible.
Spill-free parallel scheduling of basic blocks (1995)

This paper concerns the problem of spill-free scheduling of basic blocks on a processor with multiple functional units and a limited number of registers. The problem of minimizing the schedule length is well known to be computationally intractable. We present a heuristic for the problem, a general divide-and-conquer paradigm that converts any insensitive scheduling algorithm-one that is insensitive to register constraints-to one that respects register constraints. We estimate the goodness of the heuristic by relating its performance to that of the insensitive algorithm. We also present experimental results obtained by applying the heuristic to basic blocks from the SPEC benchmark programs, for several machine models.
PRODUCING PUBLIC-USE MICRODATA THAT ARE ANALYTICALLY VALID AND CONFIDENTIAL (1998)

This paper compares several masking methods in terms of their ability to produce analytically valid, confidential microdata.
Bee venom processes human skin lipids for presentation by CD1a (2015)

Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms contain CD1-presented antigens. Here, we show that venoms activate human T cells via CD1a proteins. Whereas CD1 proteins typically present lipids, chromatographic separation of venoms unexpectedly showed that stimulatory factors partition into protein-containing fractions. This finding was explained by demonstrating that bee venom-derived phospholipase A2 (PLA2) activates T cells through generation of small neoantigens, such as free fatty acids and lysophospholipids, from common phosphodiacylglycerides. Patient studies showed that injected PLA2 generates lysophospholipids within human skin in vivo, and polyclonal T cell responses are dependent on CD1a protein and PLA2. These findings support a previously unknown skin immune response based on T cell recognition of CD1a proteins and lipid neoantigen generated in vivo by phospholipases. The findings have implications for skin barrier sensing by T cells and mechanisms underlying phospholipase-dependent inflammatory skin disease.
Sterols Accelerate Degradation of Hamster 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Encoded by a Constitutively Expressed cDNA (1985)

A recombinant plasmid containing a full-length cDNA for hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase was introduced by calcium phosphate-mediated transfection into UT-2 cells, a mutant line of Chinese hamster ovary cells that lack 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and thus require low density lipoprotein-cholesterol and mevalonate for growth. We selected a line of permanently transfected cells, designated TR-36 cells, that expressed high levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and thus grew in the absence of low density lipoprotein and mevalonate. Constitutive synthesis of reductase mRNA in TR-36 cells was driven by the simian virus 40 early promoter, and therefore the mRNA was not suppressed by sterols, such as 25-hydroxycholesterol or cholesterol derived from low density lipoprotein, which normally suppresses transcription of reductase mRNA when the reductase gene is driven by its own promoter. Although TR-36 cells continued to synthesize large amounts of reductase mRNA and protein in the presence of sterols, reductase activity declined by 50 to 60%. This decline was caused by a twofold increase in the rate of degradation of preformed enzyme molecules. The current data demonstrate that sterols accelerate the degradation of reductase protein independently of any inhibitory effect on the synthesis of the protein.
Hydrogels based on pH-responsive reversible carbon–nitrogen double-bond linkages for biomedical applications (2018)

This review outlines recent progress of pH-responsive hydrogels based on condensation reactions between nucleophiles and carbonyl groups for biomedical applications.
Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms (2003)

Transplantation tolerance can be induced in adult rodents using monoclonal antibodies against coreceptor or costimulation molecules on the surface of T cells. There are currently two well-characterized populations of T cells, demonstrating regulatory capacity: the "natural" CD4+CD25+ T cells and the interleukin (IL)-10-producing Tr1 cells. Although both types of regulatory T cells can induce transplantation tolerance under appropriate conditions, it is not clear whether either one plays any role in drug-induced dominant tolerance, primarily due to a lack of clear-cut molecular or functional markers. Similarly, although dendritic cells (DCs) can be pharmacologically manipulated to promote tolerance, the phenotype of such populations remains poorly defined. We have used serial analysis of gene expression (SAGE) with 29 different T-cell and antigen-presenting cell libraries to identify gene-expression signatures associated with immune regulation. We found that independently derived, regulatory Tr1-like clones were highly concordant in their patterns of gene expression but were quite distinct from CD4+CD25+ regulatory T cells from the spleen. DCs that were treated with the tolerance-enhancing agents IL-10 or vitamin D3 expressed a gene signature reflecting a functional specification in common with the most immature DCs derived from embryonic stem cells.
Defected ground structure microstrip bandpass filter with multiple finite transmission zeros (2008)

A microstrip bandpass filter (BPF) using a defected ground structure (DGS) is presented in this paper. The introduced DGS filter enables three transmission zeros (TZs) to be realized, and the mechanism of realizing TZs is investigated. Centered at 2.0 GHz, a demonstrator filter is optimally designed, fabricated and examined. Experimental verification is provided and good consistency between simulations and measurements is also observed.
Optimization of HNO Production from <i>N</i> , <i>O</i> - <i>bis</i> -Acylated Hydroxylamine Derivatives (2011)

A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.
Measurement of electrical activity of the human small intestine using surface electrodes (1993)

Electrical activity of the human small intestine is usually measured by implanted or intraluminal electrodes. The application of these invasive techniques is, however, very limited. In this paper, a noninvasive technique is introduced to measure electrical activity of the small intestine by placing electrodes on the abdominal skin over the small intestine. Surface recordings were obtained in ten healthy volunteers, three patients with total gastrectomy and five patients with gastroparesis (a slight degree of paralysis of the mucosal coat of the stomach) with implanted electrodes on the serosa of the duodenum. An omnipresent 9-12 cpm electrical activity was observed in all surface recordings. Our findings from the surface electrodes were consistent with those reported in the literature via implanted or intubated electrodes. It is concluded that the technique described in this paper provides a noninvasive way to measure electrical activity of the small intestine. It may have potential application in medical research and clinical diagnosis.
Acute Stroke Care in the US (2005)

A minority of acute stroke patients are treated according to established guidelines. Quality improvement interventions, targeted primarily at the health care systems level, are needed to improve acute stroke care in the United States.
A Neural Network for Generating Adaptive Lessons (2005)

Traditional sequencing technology developed in the field of intelligent tutoring systems
have not find an immediate place in large-scale Web-based education. This study investigates the use
of computational intelligence for adaptive lesson generation in a distance learning environment over
the Web. An approach for adaptive pedagogical hypermedia document generation is proposed and
implemented in a prototype called KnowledgeClass. This approach is based on a specialized artificial
neural network model. The system allows automatic generation of individualised courses according to
the learner’s goal and previous knowledge and can dynamically adapt the course according to the learner’s success in acquiring knowledge. Several experiments showed the effectiveness of the proposed method.
Ultra-broadband and gain-flattened EDFAs for WDM signals (1997)

This paper reviews recently developed ultra-broadband EDFAs which include an amplifier composed of a 1.55 μm-band and a 1.58 μm-band gain-flattened EDFA in a parallel configuration and an Er3+-doped tellurite fiber amplifier. Furthermore, it dcscribes improvements in the 1.55 μm-band gain-flattened fluoride-based EDFA.
Intestinal absorption of gabapentin in rats. (1991)

Gabapentin (1-aminomethyl-)cyclohexaneacetic acid, Gö 3450, CI-945; CAS 60142-96-3) is a new gamma-aminobutyric acid (GABA) analogous compound that has shown an anticonvulsive effect as well as low toxicity in preclinical and clinical studies. The substance is well absorbed after oral administration and penetrates the blood-brain barrier. The aim of experiments was to study the mechanism of intestinal absorption, the relationship between the absorption rate and the applied concentration and whether the absorption rate differs between different parts of the intestine. For this purpose, isolated intestinal segments of rats (everted sac preparations) were used. Due to the fact that gabapentin is not metabolized in the intestine, its concentration in the mucosal and serosal compartments could be determined by scintillation counting of 3H-gabapentin. The results showed that gabapentin was absorbed by simple diffusion because neither indications for an uphill nor for a carrier-mediated transport could be demonstrated. The absorption rate was linearly related in the concentration range from 0.001 to 100 mmol/l. There was no significant difference between the absorption rate in the three parts of the small intestine at 1 and 10 mmol/l, while the absorption rate was significantly (p less than 0.01) lower in the colon.
Out-of-core divisible load processing (2003)

In this paper, we analyze processing divisible loads in systems with a memory hierarchy. Divisible loads are computations that can be divided into parts of arbitrary sizes and these parts can be independently processed in a distributed system. The problem is to partition the load so that the total processing time, including communications and computations, is the shortest possible. Earlier works in the divisible load theory assumed distributed systems with a flat memory model. The dependence of the processing time on the size of the assigned load was assumed to be linear. A new mathematical model relaxing the above two assumptions is proposed in this article. We study distributed systems-which have both the hierarchical memory model and a piecewise linear dependence of the processing time on the size of the assigned load. Performance of such systems is modeled and evaluated. Finally, we compare the efficiency of distributed processing divisible loads in multiinstallment and out-of-core modes. Multiinstallment processing consists in sending multiple small chunks of the load to processors instead of a single chunk which needs external memory. It turns out that multiinstallment is an advantageous strategy for reasonably selected load chunks sizes.
Preparation Technique and Properties of Nano-TiO2 Photocatalytic Coatings for Asphalt Pavement (2018)

According to the characteristics of asphalt pavement, a kind of nano-TiO2 photocatalytic coating was prepared by using the emulsified asphalt as the carrier. All of its properties met the technical requirements. An exhaust gas degradation test device and its test steps were developed. The evaluation indexes, cumulative degradation rate, and degradation efficiency, were put forward. From the two aspects of the nano-TiO2 content in photocatalytic coatings and the spraying amount of photocatalytic coatings in the surface of slabs (300 mm × 300 mm), the exhaust gas degradation effects, the performances of skid resistance, and the water permeability of asphalt mixture were analyzed. The test results showed that the cumulative degradation rate of exhaust gas was better when nano-TiO2 content was increased in the range of 0–8% and the spraying amount was changed in the range of 0–333.3 g/m2. In practical engineering applications, the anti-skid performance of asphalt pavement can be satisfied when the spraying amount of photocatalytic coating was limited to under 550 g/m2. The spraying amount of nano-TiO2 photocatalytic coating had little effect on the water permeability of the asphalt mixture. Therefore, 8% nano-TiO2 content in the coating and a 400 g/m2 spraying amount were finally recommended based on the photocatalytic properties, as well as for economic reasons.
Chemistry of Some Sulfur Oxyfluorides<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Some Sulfur Oxyfluorides1E. L. Muetterties and D. D. CoffmanCite this: J. Am. Chem. Soc. 1958, 80, 22, 5914–5918Publication Date (Print):November 1, 1958Publication History Published online1 May 2002Published inissue 1 November 1958https://pubs.acs.org/doi/10.1021/ja01555a005https://doi.org/10.1021/ja01555a005research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anti-quorum sensing activity of phenolic extract from Eugenia brasiliensis (Brazilian cherry) (2016)

The aim of this study was to assess the anti-quorum sensing activity of phenolic extracts from grumixama (Eugenia brasiliensis), also known as Brazilian cherry, in concentrations that did not interfere with bacterial growth. The pulp phenolic compounds were extracted by using solid phage extraction in a mini-collumn C18 and quantified by spectrophotometry. The anti-quorum sensing activity was evaluated by testing the inhibition of violacein production in Chromobacterium violaceum and by evaluating the swarming motility in Aeromonas hydrophila and Serratia marcescens, both phenotypes regulated by quorum sensing. The phenolic extract strongly inhibited the production of violacein in C. violaceum, reducing its production in comparison with a control with no extract. No inhibition of growth was observed at the concentrations tested for quorum sensing inhibition. Confirming the quorum sensing inhibition phenotype, the extract was also able to inhibit swarming motility in S. marcescens and in A. hydrophila, although in the later the effect was marginal. Overall, these results indicate that phenolic extract from E. brasiliensis presents quorum sensing inhibitory activity most likely due to the presence of fruit phenolics which have been implicated as quorum sensing inhibitors in Gram negative bacteria.
Hydrogenation of carbon monoxide on Co/MgAl2O4 catalysts. Part 1. Effect of support composition. (1984)

F-T合成により液状炭化水素 (C5+) を得る目的で, Al2O3担体 (3種) とAl2O3/MgO比の異なるスピネル担体 (6種) とに4wt%のCoを担持した触媒のCO転化率とC5+生成量とを評価した。スピネルが良好な担体であることを見い出し, さらに, 組成比の異なる担体の効果を明らかにするため, CO吸着量•COの水素化に対するパルス表面反応速度定数並びにCOの昇温脱離パターンを求めた。C5+生成には15～18mol% Al2O3過剰の担体が適し, これらの担体を用いた触媒ではCO脱離は高温で, 一方, CO2脱離 (COの不均化反応) は低温で起こる。F-T合成により得られる炭化水素はC1～C24の範囲にあり, C9とC16とにピークを持つ二つ山型の分布を示した。
MASS SPEC TACKLES PROTEINS (2006)

RETURN TO ISSUEPREVNewsNEXTMASS SPEC TACKLES PROTEINSMass spectrometry shines in applications from proteomics to structural biology, but challenges remainCELIA HENRY ARNAUDView Author Information C&EN WASHINGTONCite this: Chem. Eng. News 2006, 84, 40, 17–25Publication Date (Print):October 2, 2006Publication History Published online14 November 2010Published inissue 2 October 2006https://pubs.acs.org/doi/10.1021/cen-v084n040.p017https://doi.org/10.1021/cen-v084n040.p017newsACS PublicationsCopyright © 2006 AMERICAN CHEMICAL SOCIETYArticle Views23Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Mass spectrometry,Modification,Peptides and proteins Get e-Alerts
Zeolitic Imidazole Framework-8 Catalysts in the Conversion of CO<sub>2</sub> to Chloropropene Carbonate (2011)

The catalytic activity of zeolitic imidazole framework-8 (ZIF-8) and amine-functionalized ZIF-8 catalysts in the synthesis of chloropropene carbonate from CO2 and epichlorohydrin is demonstrated. In contrast to hitherto known catalysts, ZIF-8 catalysts displayed high epoxide conversions and moderate to high selectivities to chloropropene carbonate at reaction temperatures as low as 70 °C. No cocatalysts or solvents were required during the reaction. The incorporation of ethylenediamine in ZIF-8 enhanced its catalytic performance as a result of the higher CO2 adsorption capacity of the amine-functionalized samples. The ZIF-8 catalysts, however, lost their distinctive crystalline structure and superior catalytic performance when attempts were made to recycle them after use.
Design in conversation (2017)

Malcolm Reading, a professional competition organizer with experience in organizing competitions for public awarding authorities, as well as for private clients, shows awareness of the in-situ character of competitions and accordingly shapes and adapts his organizational work to the specific needs of particular local situations and circumstances. Malcolm Reading Consultants (MRC) provides pre-project services, briefing and strategic advice on capital projects in the UK and worldwide. Over the last decade, MRC's competitions have brought emerging designers to world attention, including Thomas Heatherwick, Amanda Levete and Steven Holl. Malcolm Reading, MRC's Founder and Chairman, trained as an architect and moved from designing to commissioning designers with his appointment as Director of Design at the British Council in the early nineties. Today, MRC includes eight staff members with varied backgrounds in architecture, urban design, graphic design, web design and journalism. Additionally, several staff members have both commercial and public sector experience.