gebhart/patrepeval huggingface dataset:
High Molecular Weight Heat-stable Alkaline Proteinase in Carp Muscle: Substrate Specificity on Synthetic Fluorogenic Substrates (1986)

Journal Article High Molecular Weight Heat-stable Alkaline Proteinase in Carp Muscle: Substrate Specificity on Synthetic Fluorogenic Substrates Get access Haruhiko Toyohara, Haruhiko Toyohara Laboratory of Fishery Chemistry, Department of Fisheries, Faculty of Agriculture, Kyoto University, Kitashirakawa, Sakyō-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasuo Makinodan Yasuo Makinodan Laboratory of Fishery Chemistry, Department of Fisheries, Faculty of Agriculture, Kyoto University, Kitashirakawa, Sakyō-ku, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 8, 1 August 1986, Pages 2131–2132, https://doi.org/10.1080/00021369.1986.10867710 Published: 01 August 1986 Article history Received: 03 February 1986 Published: 01 August 1986
Determination of Nitrite by Pre-Column Derivatization and High-Performance Liquid Chromatography (1992)

Abstract Nitrite has been determined by reversed-phase high-performance liquid chromatography by its pre-column reaction with 2-aminobiphenyl to give a diazonium salt and with iodide to form 2-iodobiphenyl. Chromatographic analysis was done using a C18-column, a mobile phase of aceto-nitrile - 0.05M sulfuric acid, 60:40 (v/v), detection at 254 nm and using biphenyl as an internal standard. The pre-column derivatization required about 8 min and the chromatographic separation was complete in about 10 min. As low as 8 μg 1−1 of nitrite could be determined with a limit of detection of 2 μg 1−1 Application of the proposed method to river water and pharmaceutical tablets has been demonstrated.
Module replication for fault-tolerant real-time distributed systems (1998)

This paper considers the problem of replicating and scheduling periodic tasks in a multiprocessor system, under timing and dependency constraints. The objective is to maximize the probability of successful completion (logically correct execution, within the time constraints) of all the tasks in the system. The authors assume a precedence graph that is general with chain, AND, OR and loop subgraphs. To achieve high probability of successful completion of the tasks in the system, several modules (that constitute the tasks) are chosen for replication and executed, regardless of whether a failure actually occurs or not. The replicated modules are chosen in an optimal way, and are added to the set of the executable tasks only if that increases the probability of successful completion. The failure model of the modules in the system is general and realistic. The allocation scheme assigns the original and the replicated modules to the processing nodes of the system, and determines their starting time as well as the schedule for communication among them. Their results improve upon the work done previously.
Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells (2000)

Vascular endothelial growth factor (VEGF) acts primarily as an endothelial cell mitogen via the "endothelial cell-specific" receptors VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR). Only a few nonendothelial cells have been shown to possess functional VEGF receptors. We therefore examined the rat renal tubular epithelial cell line NRK52-E. NRK52-E expressed VEGFR-1 and VEGFR-2 mRNA and protein by RT-PCR, Northern blotting, Western blotting, immunofluorescence, and ligand binding. Serum-starved NRK52-E incubated with VEGF showed a significant increase in [(3)H]thymidine incorporation compared with control (2.3-fold at 1-10 ng/ml, P < 0. 05; 3.3-fold at 50-100 ng/ml, P < 0.01). VEGF also protected NRK52-E from hydrogen peroxide-induced apoptosis and necrosis compared with control (annexin-V-FITC-positive cells, 39 vs. 54%; viable cells, 50. 5 vs. 39.7%). Immunohistochemical staining using a variety of antibodies showed expression of both VEGF receptors in normal rat renal tubules in vivo. Because VEGF induced a proliferative and an antiapoptotic response in renal tubular epithelial cells, these data suggest that VEGF may act as a survival factor for renal tubular epithelium in vivo.
Precision voltage-divider circuit (1971)

A base-current-cancellation scheme is used to improve the performance of a previously discussed class of transistor voltage-divider circuits having small source loading, low output resistance and low temperature coefficient. The technique described is suitable for use with Zener-diode reference sources in voltage-regulator circuits and analogue-digital convertors.
Algorithmic aspects of vertex elimination (1975)

We consider a graph-theoretic elimination process which is related to performing Gaussian elimination on sparse symmetric and unsymmetric systems of linear equations. We discuss good algorithms for finding elimination orderings, showing that a generalization of breadth-first search, called lexicographic search, can be used to find perfect orderings in 0(n+e) time and minimal orderings in 0(ne) time, if the problem graph is undirected and has n vertices and e edges. We also give efficient (though slower) algorithms for generating such orderings on directed graphs. We claim that the minimum ordering problem for directed graphs is NP-complete, and conjecture that it is also NP-complete for undirected graphs. We include a brief discussion of the relation of elimination to transitive closure and discuss some unresolved, more general, issues.
LCA of Biogas Through Anaerobic Digestion from the Organic Fraction of Municipal Solid Waste (OFMSW) Compared to Incineration of the Waste (2009)

Production of biogas through anaerobic digestion (AD) from the organic fraction of minucipal solid waste (OFMSW) was compared to incineration of the waste. At the moment, almost all of the OFMSW in Singapore is incinerated. Three different scales of biogas plants were compared to incineration: one large-scale biogas plant that can treat half of all OFMSW in Singapore; one medium- scale biogas plant about 15 times smaller than the large one; and one small-scale biogas plant that can treat waste from e.g. a shopping centre or food centre. Two alternatives for utilization of the biogas were also compared, generation of electricity and the use of the biogas in heavy vehicles. The combination of the different scales and the different utilization gives the six different scenarios. By using life cycle assessment (LCA) the different scenarios were compared in terms of global warming potential (GWP), acidification, eutrophication, energy use and land use. The results show that biogas production creates less environmental impact than incineration. The use of the gas as a vehicle fuel creates a bigger decrease of GWP, acidification and eutrophication than when using the gas for electricity generation. The prevention of leakage of biogas during production and upgrading is crucial for the environmental impact on GWP. A leakage of only a few percent of the produced gas will lead to a loss of all the gain in saved GHG-emissions.
Targeted overexpression of androgen receptor with a liver-specific promoter in transgenic mice. (1996)

The rodent liver displays marked age- and sex-dependent changes in androgen sensitivity due to the sexually dimorphic and temporally programmed expression of the androgen receptor (AR) gene. We have altered this normal phenotype by constitutive overexpression of the rat AR transgene in the mouse liver by targeting it via the human phenylalanine hydroxylase (hPAH) gene promoter. These transgenic animals in their heterozygous state produce an approximately 30-fold higher level of the AR in the liver as compared with the nontransgenic control. Androgen inactivation via sulfonation of the hormone by dehydroepiandrosterone sulfotransferase (DST), an androgen-repressible enzyme, also contributes to the age- and sex-dependent regulation of hepatic androgen sensitivity. DST has a broad range of substrate specificity and is responsible for the age- and sex-specific activation of certain polycyclic aromatic hepatocarcinogens as well, by converting them to electrophilic sulfonated derivatives. In the transgenic female, the hepatic expression of DST was approximately 4-fold lower than in normal females, a level comparable to that in normal males. The hPAH-AR mice will serve as a valuable model for studying the sex- and age-invariant expression of liver-specific genes, particularly those involved in the activation of environmental hepatocarcinogens such as the aromatic hydrocarbons.
Protein kinase C. Its role in ischemic preconditioning in the rat. (1994)

The present study investigated whether protein kinase C (PKC) plays a role in ischemic preconditioning in the rat heart. Chelerythrine, a specific antagonist of PKC, and 1,2-dioctanoyl-sn-glycerol (DOG), a diacylglycerol analogue and specific antagonist of PKC, were used to determine whether preconditioning could be blocked or triggered, respectively. Sprague-Dawley rats were anesthetized and instrumented for coronary occlusion and reperfusion. All animals were subjected to 45 minutes of regional ischemia (ISC) followed by 2.5 hours of reperfusion. The preconditioning protocol consisted of 5 minutes of ischemia and then 10 minutes of reperfusion. There were six groups: (1) control (group C, n = 5), (2) preconditioned and ISC (group PC, n = 6), (3) chelerythrine given 2 minutes before ISC (group CC, n = 5), (4) preconditioned and chelerythrine given 2 minutes before ISC (group PCC, n = 6), (5) DOG (dissolved in dimethylsulfoxide [DMSO]) given 10 minutes before ISC (group CD, n = 5), and (6) DMSO given 10 minutes before ISC (group DMSO, n = 3). The end point was infarct size measured using triphenyl tetrazolium chloride and expressed as a percentage of the volume at risk (I/R), measured with fluorescent particles. I/R was significantly reduced by preconditioning (group C, 58.6 +/- 5.0%; group PC, 32.7 +/- 6.3%; P < .01) and by the PKC agonist DOG, which reduced I/R to a similar extent as preconditioning (group C, 58.6 +/- 5.0%; group CD, 28.0 +/- 7.0%; P < .01).(ABSTRACT TRUNCATED AT 250 WORDS)
Host-specific alterations in viral RNA accumulation and infection spread in a brome mosaic virus isolate with an expanded host range (1995)

To facilitate studies of virus-host interaction and the determinants of viral host range, we constructed full-length cDNA clones to all three genomic RNAs of an unusual brome mosaic virus (BMV) isolate with an expanded host range. While other BMV strains, including the previously cloned M1 strain, systemically infect barley and other grasses but not legumes, the expanded-host-range isolate and the set of transcripts from its cDNA clones, designated the M2 strain of BMV, systemically infect both barley and cowpea line TVu-612, a legume. All reassorted combinations of M1 and M2 genomic RNAs were equally competent for replication in barley protoplasts and systemic infection of barley plants but showed widely varying levels of viral RNA accumulation in cowpea protoplasts and systemic infection in TVu-612 cowpea plants. Systemic infection levels were influenced by all three genomic RNAs. M2 RNA2 and M2 RNA3 made independent and additive contributions to the frequency with which reassortants infected TVu-612 systemically. The greater individual effect segregated with M2 RNA3, which encodes functions required for infection spread (the 3a movement protein and coat protein). M2 RNA3 also directed accelerated expansion of BMV lesions in inoculated TVu-612 leaves. If the inoculum contained M2 RNA3, the frequency with which reassortants infected TVu-612 systemically could be further enhanced by the presence of M2 RNA1 rather than M1 RNA1. RNA1 encodes the 1a RNA replication protein, and despite similar accumulation in barley protoplasts, in cowpea protoplasts all reassortants bearing M2 RNA1 accumulated positive- and negative-strand RNAs to levels at least six- to eightfold higher than reassortants bearing M1 RNA1. Overall, the results indicate that changes in several distinct virus functions contribute to adapting BMV-M2 to systemically infect TVu-612 cowpea.
Concept learning and the problem of small disjuncts (1989)

Ideally, de nitions induced from examples should consist of all, and only, disjuncts that are meaningful (e.g., as measured by a statistical signi cance test) and have alowerror rate. Existing inductive systems create de nitions that are ideal with regard to large disjuncts, but far from ideal with regard to small disjuncts, where a small (large) disjunct is one that correctly classi es few (many) training examples. The problem with small disjuncts is that many ofthemhavehigh rates of misclassi cation, and it is di cult to eliminate the error-prone small disjuncts from a de nition without adversely a ecting other disjuncts in the de nition. Various approaches to this problem are evaluated, including the novel approach ofusing a bias di erent than the \\maximum generality &quot; bias. This approach, and some others, prove partly successful, but the problem of small disjuncts remains open. Support for this researchwas provided by the Army Research O Science Foundation under grant IRI-8620052. ce under grantARO-DAAG29-84-K-0060 and the National 1 The Problem of Small Disjuncts Systems that learn from examples do not usually succeed in creating a purely conjunctive
Cutting edge: protective response to pulmonary injury requires gamma delta T lymphocytes. (1999)

Gamma delta intraepithelial lymphocytes are thought to coordinate responses to pathogens that penetrate the epithelial barrier. To directly test this, mice were inoculated with Nocardia asteroides. At doses that were nonlethal for control mice, gamma delta-deficient mice became severely ill and died within 14 days. Histologic examination of these lungs demonstrated the presence of severe tissue damage and unimpeded bacterial growth in the gamma delta-deficient mice compared with neutrophilic lesions and clearance of the organism in control mice. Interestingly, ozone exposure that targets a comparable lung region also resulted in diffuse epithelial necrosis associated with a similar lack of neutrophil recruitment in gamma delta-deficient mice. These data demonstrate that gamma delta intraepithelial lymphocytes can protect the host from pathogenic and nonpathogenic insults by targeting the inflammatory response to epithelial necrosis.
Clock and carrier recovery for coherent receivers (2015)

Clock and carrier recovery architectures and alternatives are given with the aim to address some known issues in the design of coherent receivers.
Dihydroxyaerothionin and Aerophobin 1. Two Brominated Tyrosine Metabolites from the Deep Water Marine Sponge Verongula rigida (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDihydroxyaerothionin and Aerophobin 1. Two Brominated Tyrosine Metabolites from the Deep Water Marine Sponge Verongula rigidaMalika Gunasekera and Sarath P. GunasekeraCite this: J. Nat. Prod. 1989, 52, 4, 753–756Publication Date (Print):July 1, 1989Publication History Published online1 July 2004Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/np50064a014https://doi.org/10.1021/np50064a014research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. (1996)

Oxerutins (O-(beta-hydroxyethyl)rutosides, HR, Venoruton) and horse chestnut extract (HCE) are active principles of first priority for the pharmacological treatment of chronic venous insufficiency (CVI). The efficacies of both compounds were shown in numerous, double-blind, randomized, placebo controlled clinical trials. Besides the direct comparison of the two compounds the aim of the study was to investigate the initial dose/maintenance dose concept for HR. 137 female, postmenopausal patients with CVI II finished the study according to protocol. Following one week placebo run-in the patients were treated either with 1000 mg/d HR, 600 mg/d HCE or 1000 mg/d for 4 weeks and than with 500 mg/d HR within the initial dose/maintainance dose concept for 12 weeks and observed for further 6 weeks. A main confirmative criterion was the volume reduction of the leg. Subjective criteria were descriptively evaluated. HR (1000 mg/d) was proven to be equivalent or better, reducing the leg volume (AUB0-18) by -5273 +/- 11418 ml.d compared to -3187 +/- 10842 ml.d under HR (1000 mg/d and 500 mg/d), and -3004 +/- 7429 ml.d under HCE-treatment. Both compounds exhibit a substantial carry-over effect. The maintenance posology of HR is able to stabilize the therapeutic obtained under initial dose conditions.
Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia. (2003)

These findings demonstrate a significant upregulation of (123)I-LDL binding by prickly pear in FH-patients invivo and indicate that prickly pear exerts a significant hypolipidemic action via receptor upregulation.
Metabolism of Intravenously Administered 17β-Estradiol-6,7-<sup>3</sup>H-3-glucoside-<sup>14</sup>C in Normal Women (1971)

17β-Estradiol-6,7-3H-3-glucoside-14C (uniformly labeled) was prepared and injected intravenously into 2 normal young women. Within about 2 hr 20% of the dose was excreted in the urine of each subject in the form of estrogen glucoside with a substantially unchanged 3H/14C ratio. Approximately 11% of the latter was identified as estrone-3-glucoside, the remainder being the compound injected. 3H-labeled estrogen glucosiduronates and, to a smaller extent, 3H-estrogen sulfates, were also excreted during the first 2 hr and these metabolites continued to appear in the urine, unaccompanied by 14C, up to and including the fourth day after injection. Recovery of 3H in the urine (including that associated with the urinary glucosides) was 60 and 81% in the 2 subjects. The steroid pattern identified in the urinary 3H-glucosiduronate fraction indicated that the major part of the injected 17β-estradiol-3-glucoside had been hydrolyzed, and that the 17β-estradiol released was metabolized in a manner similar to that of intravenously injected 17β-estradiol.
Wafer‐scale monolithic hybrid integration of <scp>Si</scp>‐based <scp>IC</scp> and <scp>III–V</scp> epi‐layers—A mass manufacturable approach for active matrix micro‐<scp>LED</scp> micro‐displays (2018)

Abstract Hybridization of silicon integrated circuits (ICs) with compound semiconductor device arrays are crucial for making functional hybrid chips, which are found to have enormous applications in many areas. Although widely used in manufacturing hybrid chips, the flip‐chip technology suffers from several limitations that are difficult to overcome, especially when the demand is raised to make functional hybrid chips with higher device array density without sacrificing the chip footprint. To address those issues, Beida Jade Bird Display Limited has developed its unique wafer‐level monolithic hybrid integration technology and demonstrated its advantages in making large‐scale hybrid integration of functional device arrays on Si IC wafers. Active matrix micro‐light‐emitting diode micro‐displays with a resolution of 5000+ pixel per inch were successfully fabricated using Beida Jade Bird Display Limited's monolithic hybrid integration technology. The general fabrication method is described, and the result is presented in this paper. The fabricated monochromatic micro‐light‐emitting diode micro‐displays exhibit improved device performance than do other micro‐display technologies and have great potentials in applications such as portable projectors and near‐to‐eye projection for augmented reality. More importantly, the wafer‐scale monolithic hybrid integration technology offers a clear path for low‐cost mass production of hybrid optoelectronic IC chips.
Nebulizer for eliminating oxygen from polarographic flow cells (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNebulizer for eliminating oxygen from polarographic flow cellsChaim. Yarnitzky and Ezra. OuzielCite this: Anal. Chem. 1976, 48, 13, 2024–2025Publication Date (Print):November 1, 1976Publication History Published online1 May 2002Published inissue 1 November 1976https://pubs.acs.org/doi/10.1021/ac50007a055https://doi.org/10.1021/ac50007a055research-articleACS PublicationsRequest reuse permissionsArticle Views25Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts