gebhart/patrepeval huggingface dataset:
MixNStream (2010)

Many Internet streaming applications, such as distributed surveillance, multimedia webcasting and video thumbnails for Internet TV channel browsing, require video mixers where streams are aggregated as a single stream before presenting to users. We consider in this paper a multi-source streaming network with distributed mixers, where streams originated from multiple sources are mixed before presented to distributed users. We are interested in minimizing the worst-case delay from the source to users via the mixers. We propose an adaptive and distributed protocol called MixNStream, which continuously reduces the network diameter in the presence of churns. Through simulations on Internet-like topologies, we show that MixNStream achieves substantially better performance as compared with the state-of-the-art in terms of network delay and network stress.
2000 Fellows Citations (2000)

AGU congratulates the thirty‐seven distinguished scientists who were selected by a committee of their peers to be AGU Fellows for 2000. This selection was based on the individuals' attainment of acknowledged eminence in a branch of geophysics. The number of Fellows selected annually is limited to no more than 0.1% of the AGU membership. The names of the new Fellows are listed below, along with citations recognizing their specific achievements.
Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons. (2003)

RNA binding proteins may be important mediators of the activity-dependent transport of mRNAs to dendritic spines of activated synapses. We used fluorescence microscopy and digital imaging techniques applied to both fixed and live cultured hippocampal neurons to visualize the localization of the mRNA binding protein, zipcode binding protein 1 (ZBP1), and its dynamic movements in response to KCl-induced depolarization at high spatial and temporal resolution. With the use of immunofluorescence, image deconvolution, and three-dimensional reconstruction, ZBP1 was localized in the form of granules that were distributed in dendrites, spines, and subsynaptic sites. KCl depolarization increased the dendritic localization of ZBP1 that was not attributed to an increase in ZBP1 expression. Live cell imaging of single cells before and after perfusion of KCl revealed the rapid and directed efflux of ZBP1 granules from the cell body into dendrites in a proximo-distal gradient. High-speed imaging of enhanced green fluorescence protein-ZBP1 granules revealed rapid anterograde and retrograde movements in dendrites as well as dynamic movements in dendritic spines. A population of ZBP1 granules colocalized with beta-actin mRNA, and their spatial association in dendrites was increased by KCl depolarization. The NMDA receptor antagonist AP-5 impaired the dendritic localization of ZBP1 and beta-actin mRNA and inhibited the KCl-induced transport of ZBP1. The activity-dependent trafficking of ZBP1 and its dynamic movements within dendritic spines provide new evidence to implicate RNA binding proteins as regulators of mRNA transport to activated synapses in response to synaptic activity.
PCL-PGLA Composite Tubular Scaffold Preparation and Biocompatibility Investigation (2006)

The objective of this paper was to fabricate a biodegradable tubular scaffold for small diameter (d<6 mm) blood vessel tissue engineering. The tube scaffold needed a porous wall for cell attachment, proliferation and tissue regeneration with its degradation. A novel method given in this paper was to coat a porous layer of poly (epsilon-caprolactone) (PCL) on the outside of a poly (glycolic-co-lactic acid) (PGLA with GA:LA=90:10) fiber braided tube to give a PCL-PGLA composite. The PGLA tube was fabricated using a braiding machine by inserting a Teflon tube with the desired diameter in center of the 20 spindles, which are the carriers of PGLA fibers. Changing the diameter of the Teflon tube can vary the inner diameter of a braided PGLA tube. Thermally induced phase separation method was used for PCL solution coating on the surface of the PGLA braided tube. Controlling the polymer concentration, non-solvent addition and quenching temperature generated the pore structures, with pore sizes ranging from 10-30 microm. The fibroblast cells were seeded on the tubular scaffold and cultured in vitro for the biocompatibility investigation. Histology results showed that the fibroblast cells proliferated on the interconnected pore of the PCL porous layer in 1 week.
Genetic Markers of Head and Neck Cancer (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Otolaryngology–Head & Neck Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Otolaryngology–Head & Neck Surgery journal
<title>Unconventional Focal-Plane Architecture (FPA)</title> (1980)

The large amounts of resources spent thus far on IR mosaic focal plane assemblies (FPA) have unfortunately as yet produced little of operational utility. The main problem areas are dynamic range, on-focal plane sianal conditioning, uniformity of performance, and producibility. These problems cannot be isolated to either the detectors or the read-out electronics individually but must be resolved in an integrated manner. New FPA architectures are called for to provide large electronics real estate while retaining low cost and producibility. One such configuration, HYMOSS, has been under development at Irvine Sensors Corporation for the past two years. HYMOSS is designed to provide the requisite dynamic range, uniformity, and noise characteristics by utilizing the third dimension in an extremely compact form.
Production of Cephalosporin C by <i>Paecilomyces persicinus</i> P-10 (1974)

After the growth of Paecilomyces persicinus P-10 in a glucose-peptone medium, filtrates were collected and analyzed for antibiotic antivity. Activities against Salmonella gallinarum ATCC 3030 and Alcaligenes faecalis ATCC 8750 (penicillin N-resistant strain) were obtained. Part of the former activity was readily inactivated by penicillinase. The fraction active against A. faecalis was isolated by passage through Amberlite XAD-2 and Amberlite IRA-68. The powder eventually obtained was subjected to paper chromatography followed by bioautography, and the activity obtained corresponded to that of a sample of cephalosporin C. Thin-layer chromatography was also employed to verify the presence of cephalosporin C in the P-10 powder. The active solids were further purified by means of paper chromatography in a solvent system consisting of n-butanol-acetic acid-water (60:15:25, vol/vol). The material obtained from this procedure yielded an infrared absorption spectrum identical to that of cephalosporin C. Similarly, the ultraviolet absorption of the purified preparation coincided with that of cephalosporin C. Exposure of the purified solids to cephalosporinase resulted in rapid inactivation of the antibiotic. In addition to penicillin N and cephalosporin C, filtrates of P. persicinus P-10 also contained deacetylcephalosporin C, deacetoxycephalosporin C, and cephalosporin P.
Histone deacetylase inhibitors, anticancerous mechanism and therapy for gastrointestinal cancers (2005)

Abstract Histone acetylation regulates gene transcription. Histone acetylation is a reversible process: histone acetyltransferases (HAT) transfer the acetyl moiety from acetyl coenzyme A to the lysine, and histone deacetylases (HDAC) remove the acetyl groups re‐establishing the positive charge in the histones. HDAC inhibitors have antiproliferative activity against human cancer cells via cell cycle arrest, pro‐differentiation, and pro‐apoptosis. In recent years, many studies have shown that specific HDAC inhibitors are helpful for gastrointestinal cancer therapy.
Phosphodiesterase 4 regulates the migration of B16-F10 melanoma cells (2012)

Phosphodiesterases (PDEs) are important regulators of signal transduction processes. Eleven PDE gene families (PDE1-11) have been identified and several PDE isoforms are selectively expressed in various cell types. PDE4 family members specifically hydrolyze cyclic AMP (cAMP). Four genes (PDE4A-D) are known to encode PDE4 enzymes, with additional diversity generated by the use of alternative mRNA splicing and the use of different promoters. While PDE4 selective inhibitors show therapeutic potential for treating major diseases such as asthma and chronic obstructive pulmonary disease, little is known concerning the role of PDE4 in malignant melanoma. In this study, we examined the role of PDE4 in mouse B16-F10 melanoma cells. In these cells, PDE4 activity was found to be ∼60% of total PDE activity. RT-PCR detected only PDE4B and PDE4D mRNA. Cell growth was inhibited by the cAMP analog, 8-bromo-cAMP, but not by the specific PDE4 inhibitors, rolipram and denbufylline, which increased intracellular cAMP concentrations. Finally, migration of the B16-F10 cells was inhibited by the PDE4 inhibitors and 8-bromo-cAMP, while migration was increased by a protein kinase A (PKA) inhibitor, PKI(14-22), and was not affected by 8-pCPT-2'-O-Me-cAMP, which is an analog of exchange protein activated by cAMP (Epac). The inhibitory effect of rolipram on migration was reversed by PKI(14-22). Based on these results, PDE4 appears to play an important role in the migration of B16-F10 cells, and therefore may be a novel target for the treatment of malignant melanoma.
ANALYSIS OF KNEE JOINT BIOMECHANICS DURING CYCLING IN PATIENTS WITH TOTAL KNEE ARTHROPLASTY (2009)

Aim: Cycling is a common activity after TKA and it has been shown that up to 50 % of the TKA patients are riding a bike and 25 % think that cycling has an important place in their life. The specific contact mechanics of tibiofemoral joint is well known during walking, however, there is little data during cycling for TKA patients. The purpose of this study was to determine the tibiofemoral contact mechanics during cycling for TKA patients. Methods: We recruited 10 patients implanted with a mobile bearing and 10 patients with a fixed bearing posterior stabilized prosthesis. An age-matched, asymptomatic control group consisted of 10 subjects. The patients were physically examined, and WOMAC index and knee society score were taken. Motion analysis was performed using a retroreflective marker based technique called “PCT”. Forces and moments during cycling were recorded with load cells at the crank shafts of the bike. Motion and load data were synchronized. Results: Resultant pedal forces showed no significant differences between study groups but the generated impulse was higher in the mobile bearing group. Patients with contra-lateral osteoarthritis showed higher forces and impulse at the operated leg. The motion analysis showed the following mean values ±SD for TKA patients/Normals: maximum flexion angle 132.5° ±16.0°/131.5° ±18.3°, minimum flexion angle 41.4° ±12.0°/40.3° ±15.7°, range of rotation in transversal plane 12.6° ±4.7°/9.9° ±3.6° and range of anterior-posterior translation 5.3 mm ±5.1 mm/2.7 mm ±0.4 mm. There were no significant differences between study groups. Discussion: In this study, force and impulse of TKA patients with contemporary prostheses were comparable to healthy subjects indicating functional restoration of the joint. Contralateral osteoarthritis may cause higher forces at the operated leg and thus, relatively higher stresses at the artificial articulation. As expected, the generated forces at the bike pedal were low (20–25% body-weight) calling for little muscle activity and low compressive joint forces. However, with a mean maximum flexion angle of 131.5°, the observed motion ranges were higher than expected. Prostheses not designed for high flexion activities could lose tibio-femoral contact during cycling with detrimental effects on wear. Still, the measured range of rotation in the transverse plane indicates that despite its posterior-stabilized design rotation is taking place with approximately the same amount as it occurs in normal subjects. This may have detrimental effects on the post at the tibial plateau and could explain the previously observed rotational damage patterns on retrieved posterior stabilized TKA specimens. Data are suggesting that leisure activities should be considered to determine the appropriate TKA design. This study will provide useful data for future design and wear testing scenarios.
Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion (2012)

Ischemia-reperfusion (I/R) injury is a leading cause of morbidity and mortality. A functional role for platelets in tissue damage after mesenteric I/R is largely unknown. The hypothesis that mesenteric I/R local and remote injury are platelet dependent was tested. Using a murine mesenteric I/R model, we demonstrate that platelets orchestrate remote lung tissue damage that follows mesenteric I/R injury and also contribute, albeit to a lesser degree, to local villi damage. While lung damage is delayed compared with villi damage, it increased over time and was characterized by accumulation of platelets in the pulmonary vasculature early, followed by alveolar capillaries and extravasation into the pulmonary space. Both villi and lung tissues displayed complement deposition. We demonstrate that villi and lung damage are reduced in mice made platelet deficient before I/R injury and that platelet transfusion into previously platelet-depleted mice before I/R increased both villi and lung tissue damage. Increased C3 deposition accompanied platelet sequestration in the lung, which was mostly absent in platelet-depleted mice. In contrast, C3 deposition was only minimally reduced on villi of platelet-depleted mice. Our findings position platelets alongside complement as a significant early upstream component that orchestrates remote lung tissue damage after mesenteric I/R and strongly suggest that reperfusion injury mitigating modalities should consider the contribution of platelets.
New era in shared C-RAN and core network: A case study for efficient RRH usage (2017)

Radio Access Network (RAN) sharing and Cloud-RAN (C-RAN) are two major candidates for next generation mobile networks. RAN sharing ensures efficient usage of network equipments among multiple mobile network operators (MNOs) and C-RAN benefits installation, evolution, management and performance improvements. Similarly, Software-Defined Networking (SDN) concept provides many features including hardware abstraction, programmable networking and centralized policy control. One of the main benefits that can be used along with these features is virtualization of RAN and core/backhaul networks to ensure network sharing among MNOs and efficient usage of the network equipments. In this work, we propose SDN-based C-RAN architecture including RAN controller integrated to virtualization controller that is crucial for core/backhaul network sharing towards next generation cellular network. In proposed architecture, eNodeB functions are shifted to the top of C-RAN controller as a consequence of separating baseband units from remote radio heads (RRHs). We further provide RRH assignment based load balancing algorithm that is executed at the top of the controller and allows sharing of RRHs among multiple MNOs. We evaluate its performance using traditional RRH distribution as benchmark and simulation results reveal that our proposed algorithm outperforms traditional distribution in terms of average number of connected user equipments to RRHs.
Cationic polymerization of 3‐methylenecyclohexene and 2‐methyl‐1,3‐pentadiene (1974)

Abstract To investigate the effect of a cyclic structure on the reactivity of conjugated dienes in cationic polymerization, a cyclic diene 3‐methylenecyclohexene ( 1 ) and the corresponding linear diene 2‐methyl‐1,3‐pentadiene ( 2 ) were synthesized and polymerized. Cationic polymerizations and copolymerizations showed that 1 was more reactive than 2 . The conjugated double bonds in 1 were proved to be less resonance‐stabilized than that in 2 . However, the conjugate cation 1 was found to be more stable than that of 2 . The combination of these two factors made the cyclic diene more reactive than the linear d+. Cationic polymerizations of 2 were fast and non‐stationary, giving low molecular weight polymers. The polymerizations proceeded mainly by the 1,4 route and to a smaller extent by the 1,2 route. A brief discussion on the stereochemistry in some electrophilic addition reactions of methyl‐substituted butadienes is also given.
Reduced fasting plasma levels of diazepam‐binding inhibitor in adolescents with anorexia nervosa (2013)

These data further extend our knowledge of neuropeptide dysfunction in AN, and plasma DBI may represent a marker for this disease, in particular considering its correlation with comorbid mood disorders.
Multilayer Sulfonated Polyhedral Oligosilsesquioxane (S-POSS)-Sulfonated Polyphenylsulfone (S-PPSU) Composite Proton Exchange Membranes (2009)

Single-layer proton exchange membranes (PEMs) have been under development for several decades. The current use of conductive polymers in PEM fuel cells has been limited primarily to single layered sulfonated fluoro polymers, e.g. Nafion. Although this architecture has certain positive characteristics, it lacks the robust properties required for use in high-temperature, low=humidity conditions. In this work, a multilayer composite PEM consisting of outer layers of sulfonated polyphenylsulfone (S-PPSU) and an inner layer blend of octa-sulfonated octaphenyl-POSS (S-POSS) and S-PPSU has been developed and shown to exhibit good conductivity, physical and chemical durability, and high strength. The multilayer composite PEM showed improved conductivity at 90 °C and 25% RH relative to analogous single-layer S-POSS-S-PPSU PEMs and to the typical sulfonated fluoro polymers currently in use.
Degradation of triphenyltin chloride on sugar beet plants and in rats (1974)

Abstract The degradation of triphenyltin chloride on the leaves of sugar beet proceeds via di‐ and mono‐phenyltin compounds to inorganic tin( IV ). This degradation scheme has also been observed in rats, as the same metabolites were found in urine and faeces of these animals. After a single application of triphenyltin chloride, more than 90% of the tin given is excreted within one week (approx. 88% with the faeces and approx. 3% with the urine). The experiments were performed with radioactive (C 6 H 5 ) 3 113 SnCl.
Two-Phase Flow Through Porous Media: Effect of an Adsorbed Polymer Layer (1988)

ABSTRACT Polyacrylamide and polysaccharide adsorption on natural water-wet sand and sandstones is shown to modify markedly the flow behavior of both water and oil. At residual oil saturation, the quantity of adsorbed polymer per gram of rock is found to be almost the same as at full water saturation, but the permeability reduction to water is increased by the presence of trapped oil droplets which reduce the flow cross-section for the water phase. The presence of adsorbed polymer always induces an increase in the water irreducible saturation due to polymer hydration water which is not expelled by contact with oil. However the oil relative permeability is shown to be little affected by adsorbed polymer over the remaining saturation range. On the basis of a capillary two-phase flow model, this phenomenon is interpreted as the result of the competition between the reduction of flow cross-sections and the enhancement of the water-wettability of the rock, with both effects having the same origin, i.e. the polymer adsorption process.
EZH2 expands breast stem cells through activation of NOTCH1 signaling (2014)

Breast cancer is the second-leading cause of cancer-related deaths in women, but the details of how it begins remain elusive. Increasing evidence supports the association of aggressive triple-negative (TN) breast cancer with heightened expression of the Polycomb group protein Enhancer of Zeste Homolog 2 (EZH2) and increased tumor-initiating cells (TICs). However, mechanistic links between EZH2 and TICs are unclear, and direct demonstration of a tumorigenic function of EZH2 in vivo is lacking. Here, we identify an unrecognized EZH2/NOTCH1 axis that controls breast TICs in TN breast carcinomas. EZH2 overexpression increases NOTCH1 expression and signaling, and inhibition of NOTCH1 activity prevents EZH2-mediated stem cell expansion in nontumorigenic breast cells. We uncover a unique role of EZH2 in activating, rather than repressing, NOTCH1 signaling through binding to the NOTCH1 promoter in TN breast cancer cells. EZH2 binding is independent of its catalytic histone H3 lysine 27 methyltransferase activity and of the Polycomb Repressive Complex 2 but corresponds instead to transcriptional activation marks. In vivo, EZH2 knockdown decreases the onset and volume of xenografts derived from TN breast TICs. Conversely, transgenic EZH2 overexpression accelerates mammary tumor initiation and increases NOTCH1 activation in mouse mammary tumor virus-neu mice. Consonant with these findings, in clinical samples, high levels of EZH2 are significantly associated with activated NOTCH1 protein and increased TICs in TN invasive carcinomas. These data reveal a functional and mechanistic link between EZH2 levels, NOTCH1 signaling activation, and TICs, and provide previously unidentified evidence that EZH2 enhances breast cancer initiation.
Macrophages release arachidonic acid, prostaglandin E2, and thromboxane in response to late complement components. (1984)

Rat peritoneal macrophages released arachidonic acid, prostaglandin E2, and thromboxane B2 when treated with normal rabbit or C6-deficient rabbit complement in vitro. Normal rabbit complement, however, was more efficient, which indicates that late complement components, in addition to the known effects of C3a and C3b, were responsible for an enhanced arachidonic acid turnover. Indeed, in the absence of the C3 cleavage products, the purified late complement components C5b6, C7, C8, and C9 stimulated the arachidonic acid, as well as the prostaglandin E2 and thromboxane B2 release. Incubation of C5b6, C7, C8, and C9 for 1 hr at 37 degrees C before addition to the macrophages abolished the stimulatory activity, being in complete agreement with the fact that a fluid phase-formed complex of C5-9 loses its membrane-binding capacity. Although the mechanism by which C5b-9-membrane interaction affects the arachidonic acid metabolism remains unclear, the data describe a new function of the late complement components.