gebhart/patrepeval huggingface dataset:
VOLTAIC TURBINAL PUNCTURE FOR THE RELIEF OF INTUMESCENT AND HYPERTROPHIC RHINITIS. (1907)

Electrolytic action on certain substances is so well known and understood by the majority of physicians that the rehearsal in this paper seems unnecessary with the exception of a few vital points to refresh the memory. The galvanic current has two known properties, chemical and thermal, electrolysis being the result of the chemical action. A marked difference in the chemical action takes place at either pole during electrolysis. The anodal or positive pole when in contact with, or immersed in, a compound fluid attracts the oxygen and acids of the electrolyzed fluid or tissue; the negative, or cathodal, attracts the hydrogen and the salines. This chemical action of the negative galvanic current, when in contact with or immersed into mucous membrane, produces decomposition and slight cauterization; the thermal effect, if the current be intense enough, will cause redness, heat, congestion, inflammation, and even sloughing in turbinal tissue. The sensory nerves
Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli (2003)

The spinothalamic tract (STT) has been classically viewed as the major ascending pathway for pain transmission while the dorsal column (DC) was thought to be involved primarily in signaling innocuous stimuli. Recent clinical studies have shown that limited midline myelotomy, which transects fibers in the DC, offers good pain relief in patients with visceral cancer pain. Experimental studies provided evidence that a DC lesion decreases the activation of thalamic neurons by visceral stimuli and suggested that this effect is due to transection of the axons of postsynaptic dorsal column (PSDC) neurons. In our study, Fos protein expression in retrogradely labeled STT and PSDC neurons in the lumbosacral enlargement in rats was used as an anatomical marker of enhanced activation to compare the role of these neurons in cutaneous and visceral pain. The noxious stimuli used were intradermal injection of capsaicin and distention of the ureter. Retrogradely labeled PSDC neurons were found in laminae III-IV and in the vicinity of the central canal. STT neurons were located in laminae I, III-VII and X. Ureter distention evoked Fos expression in PSDC and STT neurons located in all laminae in which retrogradely labeled cells were found, with the maximum in the L(2) spinal segment. The Fos-positive PSDC neurons represented a significantly higher percentage of the retrogradely labeled PSDC neurons (19.3+/-2.3% SEM) than of the STT Fos-positive neurons (13.2+/-1.5% SEM). Intradermal capsaicin injection also evoked Fos expression in both PSDC and STT neurons, but with no significant difference between these two, when expressed as a percentage of the retrogradely labeled cells (11.6+/-2.9% SEM, 10.8+/-1.1% SEM). These results show that both PSDC and STT neurons are activated by cutaneous and visceral noxious stimuli. Their particular role in transmission and modulation of painful stimuli needs to be investigated further.
Effect of negative pressure wound therapy on wound healing (2014)

The efficacy of NPWT in promoting wound healing has been largely accepted by clinicians, yet the number of high-level clinical studies demonstrating its effectiveness is small and much more can be learned about the mechanisms of action. In the future, hopefully we will have the data to assist clinicians in selecting optimal parameters for specific wounds including interface material, waveform of suction application, and the amount of suction to be applied. Further investigation into specific interface coatings and instillation therapy are also needed. We believe that advances in mechanobiology, the science of wound healing, the understanding of biofilms, and advances in cell therapy will lead to better care for our patients.
Copolymerization of fluorinated monomers with nonfluorinated monomers. Reactivity and mechanisms (1994)

Abstract The copolymerization of two monomers usually leads to random copolymers except when one of both bears an electron‐acceptor group and the other one has an electron‐donor group. Many copolymers are commercially available, mainly in the series of hydrogenated monomers (S.M.A., GANTREZ, MALIALIM resins). The field of fluorinated copolymers is very interesting because of the strong electron‐acceptor behaviour of the fluorine atoms and more generally of halogenated atoms. Thus, after HALAR (CTFE a) ‐ethylene), TEFZEL (TFE‐ethylene) and AFLAS (TFE b) ‐propylene) resins, a new series of resins have been produced (copolymers of CTFE and vinyl ethers commercialized by ASAHI Corp.). So it can be considered that ACCEPTOR‐DONOR copolymerization with fluorinated monomers is one of the most important applications of that kind of research. After reminding the main mechanisms of that reaction (homopolymerization of charge transfer complex and copolymerization of free monomers), it will be discussed about the mechanism in some examples (CTFE‐vinyl ethers and other pairs of monomers). Then it will be explained how cotelomerization has provided new data to prefer a copolymerization mechanism by free monomers.
Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice (2001)

Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examined the responses in mast cell-deficient (Kit(W)/Kit(W-v)), congenic normal (+/+), and Kit(W)/Kit(W-v) mice that were reconstituted with bone marrow stem cells (BMR) to restore mast cells. All mice were actively sensitized and challenged intravesically with either saline or specific antigen. Bladder inflammation occurred in +/+ and BMR but not the Kit(W)/Kit(W-v) mice. Gene expression was determined using mouse cDNA expression arrays. Self-organizing maps, performed without preconditions, indicated gene expression changes dependent on the presence of mast cells. These genes were upregulated in bladders isolated from antigen challenge of +/+, not altered in Kit(W)/Kit(W-v), and were upregulated in BMR mice. Taken together these results demonstrate an important role for mast cells in allergic cystitis and indicate that mast cells can alter their environment by regulating tissue gene expression.
Delay-Tolerant Algorithms for Asynchronous Distributed Online Learning (2014)

We analyze new online gradient descent algorithms for distributed systems with large delays between gradient computations and the corresponding updates. Using insights from adaptive gradient methods, we develop algorithms that adapt not only to the sequence of gradients, but also to the precise update delays that occur. We first give an impractical algorithm that achieves a regret bound that precisely quantifies the impact of the delays. We then analyze AdaptiveRevision, an algorithm that is efficiently implementable and achieves comparable guarantees. The key algorithmic technique is appropriately and efficiently revising the learning rate used for previous gradient steps. Experimental results show when the delays grow large (1000 updates or more), our new algorithms perform significantly better than standard adaptive gradient methods.
Topochemical Polymerization in Supramolecular Polymers of Oligopeptide‐Functionalized Diacetylenes (2006)

Diacetylene macromonomers functionalized with a β-sheet-forming oligopeptide and a hydrogenated poly(isoprene) coil segment self-assembled into supramolecular polymers with a double-helical, tubular topology and a diameter of a few nanometers. Subsequent “1D topochemical polymerization” affords poly(diacetylene)s with a conjugated backbone and a high degree of biochemically relevant functionalization, as well as a defined hierarchical structure. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600610_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Research and Simulation of Data Hiding Algorithm in Military Image Encryption Communication (2015)

The paper presented a reversible data hiding algorithm using random integrated mode. Edge features of military image were directly extracted to fully excavate the visual masking properties of military image. Through military image block variance,the edge features was depicted,ensuring the integrity of the military image edge. The acquired sub-image of military image and the military difference image between reference sub-images were constructed. Through the extraction method of data hiding,the hiding data of difference image in military image were composed to form the corresponding data hidden code stream,to complete the scrambling operations of all military difference images. The hiding data in military figure after scrambling were measured according to the accuracy of the data hiding,to realize the data hiding of military image encryption communication. The simulation results show that the effect and hiding capacity of using proposed method for the data hiding in military image encryption communication are superior to traditional methods,verifying the effectiveness of the proposed method.
Insulin Pumps and Glucose Regulation (2001)

With recent technologic advances there has been a resurgence of interest in implantable insulin infusion devices. A satisfactory closed loop system has been elusive. Open loop systems include the pump, delivery catheter, and patient pump communicator. Several such systems are currently undergoing clinical investigation. Implantable pumps can be placed with minimal morbidity. Insulin underdelivery is the most frequent long-term problem. Several recent studies suggest that implantable pumps can safely and effectively maintain good glucose control. The development of a satisfactory implantable closed loop system will be the next step in this technology.
Li4NiTeO6 as a positive electrode for Li-ion batteries (2013)

Layered Li4NiTeO6 was shown to reversibly release/uptake ∼2 lithium ions per formula unit with fair capacity retention upon long cycling. The Li electrochemical reactivity mechanism differs from that of Li2MO3 and is rooted in the Ni(4+)/Ni(2+) redox couple, that takes place at a higher potential than conventional LiNi1-xMnxO2 compounds. We explain this in terms of inductive effect due to Te(6+) ions (or the TeO6(6-) moiety).
The influence of model parameters on EEG/MEG single dipole source estimation (1987)

This paper deals with source localization and strength estimation based on EEG and MEG data. It describes an estimation method (inverse procedure) which uses a four-spheres model of the head and a single current dipole. The dependency of the inverse solution on model parameters is investigated. It is found that sphere radii and conductivities influence especially the strength of the EEG equivalent dipole and not its location or direction. The influence on the equivalent dipole of the gradiometer is investigated. In general the MEG produces better location estimates than the EEG whereas the reverse is found for the component estimates. An inverse solution simultaneously based on EEG and MEG data appears slightly better than the average of separate EEG and MEG solutions. Variances of parameter estimators which can be calculated on the basis of a linear approximation of the model, were tested by Monte Carlo simulations.
Harmonic Rejection Mixing Techniques Using Clock-Gating (2013)

In this paper, harmonic rejection (HR) mixing techniques to obtain a high level of HR are described. This is achieved by reducing the sensitivity to mismatches in devices operating at high frequencies. A design fabricated in a 110-nm CMOS process rejects up to the first 14 local oscillator (LO) harmonics and achieves third, fifth, and seventh HR ratios in excess of 52, 54, and 55 dB, respectively, without any calibration or trimming. This mixer also rejects flicker noise and has improved quadrature matching and IIP2 performance. By using a clock N times the desired LO frequency, this scheme rejects the (N-1)th LO harmonic only by an amount of 20log(N-1) dB. A new technique is presented that enables better HR for the (N-1)th harmonic while preserving the level of rejection for other harmonics. This mixer fabricated in a 55-nm standard CMOS process has a programmable number of 8, 10, 12, or 14 mixer phases and achieves an improvement of 29 dB for the (N-1)th harmonic while achieving 52 dB of rejection for the third harmonic. It also rejects flicker noise and has an IIP2 performance of 68 dBm.
Scale-variant topological information for characterizing the structure of complex networks (2019)

The structure of real-world networks is usually difficult to characterize owing to the variation of topological scales, the nondyadic complex interactions, and the fluctuations in the network. We aim to address these problems by introducing a general framework using a method based on topological data analysis. By considering the diffusion process at a single specified timescale in a network, we map the network nodes to a finite set of points that contains the topological information of the network at a single scale. Subsequently, we study the shape of these point sets over variable timescales that provide scale-variant topological information, to understand the varying topological scales and the complex interactions in the network. We conduct experiments on synthetic and real-world data to demonstrate the effectiveness of the proposed framework in identifying network models, classifying real-world networks, and detecting transition points in time-evolving networks. Overall, our study presents a unified analysis that can be applied to more complex network structures, as in the case of multilayer and multiplex networks.
THE GENETICS OF PEROXISOME BIOGENESIS (2000)

The segregation of metabolic functions within discrete organelles is a hallmark of eukaryotic cells. These compartments allow for the concentration of related metabolic functions, the separation of competing metabolic functions, and the formation of unique chemical microenvironments. However, such organization is not spontaneous and requires an array of genes that are dedicated to the assembly and maintenance of these structures. In this review we focus on the genetics of peroxisome biogenesis and on how defects in this process cause human disease.
Design of a soft-error tolerant 9-transistor/6-magnetic-tunnel-junction hybrid cell based nonvolatile TCAM (2014)

This paper introduces a soft-error tolerant ternary content-addressable memory (TCAM) cell based on a transistor/magnetic-tunnel-junction (MTJ) hybrid structure. The MTJ device stores one-bit information as a resistance value and is often used for non-volatile memories. In the proposed nine-transistor (9T)/six-MTJ (6MTJ) cell, one-bit information is redundantly represented using three MTJs to mask a one-bit error per cell that might be occurred due to particle strikes. Thanks to the stackability of the MTJ device over a CMOS layer, there is no area overhead due to the redundancy compared to a conventional 9T-2MTJ cell. A 256-word 64-bit TCAM based on the proposed cell is designed under a 90nm CMOS/MTJ process and is evaluated using HSPICE simulation. The simulation results show that the proposed TCAM properly operates under a one-bit error per cell with comparable energy, area and a 14% delay overhead compared to the conventional TCAM. Compared to a CMOS-based TCAM with an error-correction code that masks a one-bit error per word, the proposed TCAM reduces the nubmer of transistors by 81% while masking a one-bit error per cell.
Hepatic expression of genes regulating lipid metabolism in rabbits. (1993)

The liver plays a central role in lipid metabolism and plasma lipoprotein homeostasis. This dynamic process is regulated by a variety of liver-derived proteins. However, the specific liver cells that express these proteins are largely unknown. In the current study we measured mRNA levels for 13 genes encoding proteins involved in lipid metabolism in isolated rabbit hepatic parenchymal and nonparenchymal cells. For these analyses we cloned partial rabbit cDNAs for apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), apolipoprotein E (apoE), cholesteryl ester transfer protein (CETP), hepatic lipase (HL), lipoprotein lipase (LPL), HMG-CoA reductase, LDL-receptor, 7 alpha-hydroxylase, albumin, bile salt-dependent cholesteryl ester hydrolase (CEH), lecithin:cholesterol acyl transferase (LCAT), and plasminogen activator inhibitor protein-1 (PAI-1). The cDNAs provided the basis for developing quantitative RNAse protection assays for each mRNA. These assays were used to determine whether differential patterns of mRNA expression existed between liver and other tissues and between hepatic parenchymal and nonparenchymal cells. The data demonstrate a diverse range in tissue distribution and mRNA abundance. Liver expressed all mRNAs except for LPL and CEH. Messenger RNA levels in isolated liver cell populations normalized to total RNA revealed a cell segregation pattern for hepatic gene expression: parenchymal cells showed higher levels of apoA-I, apoB, apoE, albumin, LCAT, HL, and 7 alpha-hydroxylase mRNAs compared to nonparenchymal cells while nonparenchymal cells showed higher levels of CETP, LDL-receptor, HMG-CoA reductase, and PAI-1 mRNAs compared to parenchymal cells. These data demonstrate the existence of differential mRNA expression patterns in rabbit liver cell populations for genes encoding proteins affecting lipid metabolism.
Methylglyoxal detoxification by an aldo-keto reductase in the cyanobacterium Synechococcus sp. PCC 7002 (2006)

Aldo-keto reductases (AKRs) are a superfamily of enzymes that reduce aldehydes and ketones, and have a broad range of substrates. An AKR gene, sakR1, was identified in the cyanobacterium Synechococcus sp. PCC 7002. A mutant strain with sakR1 inactivated was sensitive to glycerol, a carbon source that can support heterotrophic growth of Synechococcus sp. PCC 7002. It was found that the sakR1 null mutant accumulated more toxic methylglyoxal than the wild-type when glycerol was added to growth medium, suggesting that SakR1 is involved in the detoxification of methylglyoxal, a highly toxic metabolite that can damage cellular macromolecules. Enzymic analysis of recombinant SakR1 protein showed that it can efficiently reduce methylglyoxal with NADPH. Based on immunoblotting, SakR1 was not upregulated at an increased cellular methylglyoxal concentration. A pH-dependent enzyme-activity profile suggested that SakR1 activity could be regulated by cellular pH in Synechococcus sp. PCC 7002. The broad substrate specificity of SakR1 implies that SakR1 could play other roles in cellular metabolism.
Neural Plasticity in Mood Disorders (2018)

The contribution of differences in cellular and anatomical function to mood disorders has been a focus of research attention in biological psychiatry for a very long time. Some of the earliest structural imaging studies demonstrated differences in the size of certain brain structures in major depression, bipolar disorder, posttraumatic stress disorder, and drug dependence This led to the search for the cellular bases of these changes and how genetic and environmental factors contribute to these differences This is, of course, a topic of much ongoing research that seeks to identify these mechanisms at a cellular and anatomical level, as well as to relate these changes to both internal and external causal factors. An understanding of these factors will not only provide an understanding of the aetiology of affective disorders but will also inform efforts to develop new treatments for these conditions.
A small stem-loop structure of the Ebola virus trailer is essential for replication and interacts with heat-shock protein A8 (2016)

Ebola virus (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family. The leader and trailer non-coding regions of the EBOV genome likely regulate its transcription, replication, and progeny genome packaging. We investigated the cis-acting RNA signals involved in RNA-RNA and RNA-protein interactions that regulate replication of eGFP-encoding EBOV minigenomic RNA and identified heat shock cognate protein family A (HSC70) member 8 (HSPA8) as an EBOV trailer-interacting host protein. Mutational analysis of the trailer HSPA8 binding motif revealed that this interaction is essential for EBOV minigenome replication. Selective 2'-hydroxyl acylation analyzed by primer extension analysis of the secondary structure of the EBOV minigenomic RNA indicates formation of a small stem-loop composed of the HSPA8 motif, a 3' stem-loop (nucleotides 1868-1890) that is similar to a previously identified structure in the replicative intermediate (RI) RNA and a panhandle domain involving a trailer-to-leader interaction. Results of minigenome assays and an EBOV reverse genetic system rescue support a role for both the panhandle domain and HSPA8 motif 1 in virus replication.
Harmful algal blooms in coastal waters: options for prevention, control and mitigation (1997)

This report is the product of a panel of experts in the science of blooms of unicellular marine algae which can cause mass mortalities in a variety of marine organisms and cause illness and even death in humans who consume contaminated seafood. These phenomena are collectively termed harmful algal blooms or HABs for short. As a counterpart to recent assessments of the priorities forscientific research to understand the causes and behavior of HABs, this assessment addressed the management options for reducing their incidence and extent (prevention), actions that can quell or contain blooms (control), and steps to reduce the losses of resources or economic values and minimize human health risks (mitigation).This assessment is limited to an appraisal of scientific understanding, but also reflects consideration of information and perspectives provided by regional experts, agency managers and user constituencies during three regional meetings. The panel convened these meetings during the latter half of 1996 to solicit information and opinions from scientific experts, agency managers and user constituencies in Texas, Washington, and Florida. The panel's assessment limited its attention to those HABs that result in neurotoxic shellfish poisoning, paralytic shellfish poisoning, brown tides, amnesic shellfish poisoning, and aquaculture fish kills. This covers most, but certainly not all, HAB problems in the U.S.
Regulation of YKL-40 production by human articular chondrocytes (2001)

The spontaneous increase in the production of YKL-40 in the early phase of culture appears to represent a cellular response to changes in the extracellular matrix environment. This, coupled with the profound suppressive effects of IL-1beta and TGFbeta on YKL-40 production, identifies a novel regulatory pattern for this major chondrocyte-derived protein.