gebhart/patrepeval huggingface dataset:
Antenna Steering System (1961)

The Project Echo experiment employed large steerable communication antennas at the ground terminals. These are highly directional transmitting and receiving antennas which must be continuously and accurately pointed at the passing satellite. While the dynamic control of antennas has not been required in prior Bell System communications, it will play an important role in future systems utilizing many orbiting repeaters.
Epstein–Barr virus infection and nasopharyngeal carcinoma (2017)

Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chinese population. A strong association between NPC risk and the HLA locus at chromosome 6p has been identified, indicating a link between the presentation of EBV antigens to host immune cells and NPC risk. EBV infection in NPC is clonal in origin, strongly suggesting that NPC develops from the clonal expansion of a single EBV-infected cell. In epithelial cells, the default program of EBV infection is lytic replication. However, latent infection is the predominant mode of EBV infection in NPC. The establishment of latent EBV infection in pre-invasive nasopharyngeal epithelium is believed to be an early stage of NPC pathogenesis. Recent genomic study of NPC has identified multiple somatic mutations in the upstream negative regulators of NF-κB signalling. Dysregulated NF-κB signalling may contribute to the establishment of latent EBV infection in NPC. Stable EBV infection and the expression of latent EBV genes are postulated to drive the transformation of pre-invasive nasopharyngeal epithelial cells to cancer cells through multiple pathways.This article is part of the themed issue 'Human oncogenic viruses'.
Implementation of a secure bridge in an Ethernet environment (1992)

The implementation of a security system that caters to the needs of an operating network, the UPC NET, is presented. The security services that this system offers are confidentiality and authentication (origin authentication and data integrity) of data transmitted on the main segment of an extended Ethernet network. The system has been designed to specifically function in the extended Ethernet network of the Polytechnic University of Catalonia. The security system has the following characteristics: it provides cryptographic security services, it does not interfere with the operation of unprotected systems, and it supports transparent operations for protected systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13 (2003)

Severe deficiency of the von Willebrand Factor (VWF)-cleaving proteinase, ADAMTS13, is associated with the development of thrombotic thrombocytopenic purpura (TTP). Several mutations spread across the ADAMTS13 gene have been identified in association with a deficiency of VWF-cleaving proteinase activity in patients with congenital TTP. The spread of these dysfunctional mutations and the domain structure of ADAMTS13 are suggestive of a complex interaction between the enzyme and its substrate. We have studied a patient with congenital TTP who is a compound heterozygote for the Thr196Ile mutation in the metalloproteinase domain and a frameshift mutation (4143-4144insA) in the second CUB domain that results in loss of the last 49 amino acids of the protein. The VWF-cleaving proteinase activity of the truncated enzyme was comparable to that of the wild-type enzyme but its secretion from transfected COS-7 cells was about 14% of the wild type.
The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids (2019)

Epilepsy is a neurological disorder that affects approximately 50 million people worldwide. There is currently no definitive epilepsy cure. However, in recent years, medicinal cannabis has been successfully trialed as an effective treatment for managing epileptic symptoms, but whose mechanisms of action are largely unknown. Lately, there has been a focus on neuroinflammation as an important factor in the pathology of many epileptic disorders. In this literature review, we consider the links that have been identified between epilepsy, neuroinflammation, the endocannabinoid system (ECS), and how cannabinoids may be potent alternatives to more conventional pharmacological therapies. We review the research that demonstrates how the ECS can contribute to neuroinflammation, and could therefore be modulated by cannabinoids to potentially reduce the incidence and severity of seizures. In particular, the cannabinoid cannabidiol has been reported to have anti-convulsant and anti-inflammatory properties, and it shows promise for epilepsy treatment. There are a multitude of signaling pathways that involve endocannabinoids, eicosanoids, and associated receptors by which cannabinoids could potentially exert their therapeutic effects. Further research is needed to better characterize these pathways, and consequently improve the application and regulation of medicinal cannabis.
Systolic Peak Detection in Acceleration Photoplethysmograms Measured from Emergency Responders in Tropical Conditions (2013)

Photoplethysmogram (PPG) monitoring is not only essential for critically ill patients in hospitals or at home, but also for those undergoing exercise testing. However, processing PPG signals measured after exercise is challenging, especially if the environment is hot and humid. In this paper, we propose a novel algorithm that can detect systolic peaks under challenging conditions, as in the case of emergency responders in tropical conditions. Accurate systolic-peak detection is an important first step for the analysis of heart rate variability. Algorithms based on local maxima-minima, first-derivative, and slope sum are evaluated, and a new algorithm is introduced to improve the detection rate. With 40 healthy subjects, the new algorithm demonstrates the highest overall detection accuracy (99.84% sensitivity, 99.89% positive predictivity). Existing algorithms, such as Billauer's, Li's and Zong's, have comparable although lower accuracy. However, the proposed algorithm presents an advantage for real-time applications by avoiding human intervention in threshold determination. For best performance, we show that a combination of two event-related moving averages with an offset threshold has an advantage in detecting systolic peaks, even in heat-stressed PPG signals.
380 nm Photoluminescence Caused by Trace Na Impurity in High-Purity Synthetic Silica Glass (1993)

In this study, 380 nm photoluminescence (PL), in the high-purity synthetic silica glass containing trace Na impurity, is observed upon excitation with ultraviolet (UV) light of wavelengths less than 240 nm. Its intensity increases with Na concentration exceeding the 1:1 concentration ratio of Na to Al. The nonbridging oxygen, pairing with the excess Na, is assumed to cause the PL, as well as an increase in the intensity of the 185 nm absorption band.
Chemistry of succinyl succinic acid derivatives. Part IV. On the hydrogenation of diethyl succinyl succinate (1979)

Abstract The Preparation of 2 new tetrasubstituted cyclohexane isomers by hydrogenation of diethyl succinyl succinate is reported. A route for their formation is postulated.
A Consistent Reaction Scheme for the Selective Catalytic Reduction of Nitrogen Oxides with Ammonia (2015)

For the first time, the standard and fast selective catalytic reduction (SCR) of NO by NH3 are described in a complete catalytic cycle that is able to produce the correct stoichiometry while allowing adsorption and desorption of stable molecules only. The standard SCR reaction is a coupling of the activation of NO by O2 with the fast SCR reaction, enabled by the release of NO2. According to the scheme, the SCR reaction can be divided into an oxidation of the catalyst by NO + O2 and a reduction by NO + NH3; these steps together constitute a complete catalytic cycle. Furthermore, both NO and NH3 are required in the reduction, and finally, oxidation by NO + O2 or NO2 leads to the same state of the catalyst. These points are shown experimentally for a Cu-CHA catalyst by combining in situ X-ray absorption spectroscopy (XAS), electron paramagnetic resonance (EPR), and Fourier transform infrared spectroscopy (FTIR). A consequence of the reaction scheme is that all intermediates in fast SCR are also part of the standard SCR cycle. The activation energy calculated by density functional theory (DFT) indicates that the oxidation of an NO molecule by O2 to a bidentate nitrate ligand is rate-determining for standard SCR. Finally, the role of a nitrate/nitrite equilibrium and the possible influence of Cu dimers and Brønsted sites are discussed, and an explanation is offered as to how a catalyst can be effective for SCR while being a poor catalyst for NO oxidation to NO2.
Identification of the Ricin Lipase Site and Implication in Cytotoxicity (2003)

Ricin is a heterodimeric plant toxin and the prototype of type II ribosome-inactivating proteins. Its B-chain is a lectin that enables cell binding. After endocytosis, the A-chain translocates through the membrane of intracellular compartments to reach the cytosol where its N-glycosidase activity inactivates ribosomes, thereby arresting protein synthesis. We here show that ricin possesses a functional lipase active site at the interface between the two subunits. It involves residues from both chains. Mutation to alanine of catalytic serine 221 on the A-chain abolished ricin lipase activity. Moreover, this mutation slowed down the A-chain translocation rate and inhibited toxicity by 35%. Lipase activity is therefore required for efficient ricin A-chain translocation and cytotoxicity. This conclusion was further supported by structural examination of type II ribosome-inactivating proteins that showed that this lipase site is present in toxic (ricin and abrin) but is altered in nontoxic (ebulin 1 and mistletoe lectin I) members of this family.
Performance Evaluation of Edge-Directed Interpolation Methods for Images (2013)

Many interpolation methods have been developed for high visual quality, but fail for inability to preserve image structures. Edges carry heavy structural information for detection, determination and classification. Edge-adaptive interpolation approaches become a center of focus. In this paper, performance of four edge-directed interpolation methods comparing with two traditional methods is evaluated on two groups of images. These methods include new edge-directed interpolation (NEDI), edge-guided image interpolation (EGII), iterative curvature-based interpolation (ICBI), directional cubic convolution interpolation (DCCI) and two traditional approaches, bi-linear and bi-cubic. Meanwhile, no parameters are mentioned to measure edge-preserving ability of edge-adaptive interpolation approaches and we proposed two. One evaluates accuracy and the other measures robustness of edge-preservation ability. Performance evaluation is based on six parameters. Objective assessment and visual analysis are illustrated and conclusions are drawn from theoretical backgrounds and practical results.
Amorphous In–Ga–Zn–O thin‐film transistor active pixel sensor x‐ray imager for digital breast tomosynthesis (2014)

The proposed a-IGZO APS x-ray imager with a pixel pitch<75 μm is capable to achieve a high spatial frequency (>6.67 lp/mm) and a low dose (<0.4 mGy) in next generation DBT systems.
Laser Isotope Separation (1974)

The separation of isotopes by photochemical processes employing high power lasers has received much attention during the past years. The method promises very efficient and economically competitive separation processes for a large number of isotopes, most notably uranium. Although no laser separation experiment has as yet produced weighable quantities of isotopic materials to date, a number of very recent experiments have shown the viability of the fundamental concepts. We shall review the basic concepts and the existing experimental work. In the course of this review we shall try to point out a number of unresolved problems open to research and discuss the requirements for the further development of high-power lasers for isotope separation. Finally, we will discuss possible applications of isotopes other than uranium and investigate the uses and the economics of titanium-50 as a large scale construction material for nuclear reactors.
Studies on Antiinflammatory Agents. I. Synthesis and Pharmacological Properties of 2'-Phenoxymethanesulfonanilide Derivatives. (1992)

Various 2'-phenoxymethanesulfonanilide derivatives were synthesized and evaluated for antiinflammatory and analgesic activities. Some compounds bearing an electron-attracting substituent at the 4'-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4'-cyano-(FK867) and 4'-acetyl-(FK3311) 2'-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development.
Re-evaluation of the taxonomic position of Streptococcus ferus. (2002)

Streptococcus ferus was originally isolated from rats and, although it is often considered a member of the 'mutans group' streptococci on the basis of phenotypic criteria, its phylogenetic position has not been investigated. Here, the relationship of this organism to other streptococcal groups has been determined by DNA-DNA hybridization and by partial sequencing of 16S rDNA and the sodA gene. S. ferus was found to be distantly related to all currently described streptococci, with no strong evidence in support of its inclusion within any of the currently recognized streptococcal groups.
Cooperative localization of an acoustic source using towed hydrophone arrays (2008)

We describe field experiments in which a team of autonomous underwater vehicles cooperatively localize an acoustic source. The team implements a data fusion algorithm to enhance the localization performance of each individual vehicle and implements a decentralized motion control algorithm so that each vehicle maneuvers to minimize the joint localization error of the acoustic source. Each autonomous underwater vehicle is equipped with a custom-designed towed hydrophone array that measures the bearing angle between the array and the acoustic source. The noise statistics of the hydrophone arrays are state-dependent, and a generalized Kalman filter that accounts for the state-dependant measurement noise is utilized for localization.
Effectiveness of an automatic tracking software in underwater motion analysis. (2013)

Tracking of markers placed on anatomical landmarks is a common practice in sports science to perform the kinematic analysis that interests both athletes and coaches. Although different software programs have been developed to automatically track markers and/or features, none of them was specifically designed to analyze underwater motion. Hence, this study aimed to evaluate the effectiveness of a software developed for automatic tracking of underwater movements (DVP), based on the Kanade-Lucas-Tomasi feature tracker. Twenty-one video recordings of different aquatic exercises (n = 2940 markers' positions) were manually tracked to determine the markers' center coordinates. Then, the videos were automatically tracked using DVP and a commercially available software (COM). Since tracking techniques may produce false targets, an operator was instructed to stop the automatic procedure and to correct the position of the cursor when the distance between the calculated marker's coordinate and the reference one was higher than 4 pixels. The proportion of manual interventions required by the software was used as a measure of the degree of automation. Overall, manual interventions were 10.4% lower for DVP (7.4%) than for COM (17.8%). Moreover, when examining the different exercise modes separately, the percentage of manual interventions was 5.6% to 29.3% lower for DVP than for COM. Similar results were observed when analyzing the type of marker rather than the type of exercise, with 9.9% less manual interventions for DVP than for COM. In conclusion, based on these results, the developed automatic tracking software presented can be used as a valid and useful tool for underwater motion analysis. Key PointsThe availability of effective software for automatic tracking would represent a significant advance for the practical use of kinematic analysis in swimming and other aquatic sports.An important feature of automatic tracking software is to require limited human interventions and supervision, thus allowing short processing time.When tracking underwater movements, the degree of automation of the tracking procedure is influenced by the capability of the algorithm to overcome difficulties linked to the small target size, the low image quality and the presence of background clutters.The newly developed feature-tracking algorithm has shown a good automatic tracking effectiveness in underwater motion analysis with significantly smaller percentage of required manual interventions when compared to a commercial software.
Synthesis and Spectroscopy of Silver-Doped PbSe Quantum Dots (2017)

Electronic impurity doping of bulk semiconductors is an essential component of semiconductor science and technology. Yet there are only a handful of studies demonstrating control of electronic impurities in semiconductor nanocrystals. Here, we studied electronic impurity doping of colloidal PbSe quantum dots (QDs) using a postsynthetic cation exchange reaction in which Pb is exchanged for Ag. We found that varying the concentration of dopants exposed to the as-synthesized PbSe QDs controls the extent of exchange. The electronic impurity doped QDs exhibit the fundamental spectroscopic signatures associated with injecting a free charge carrier into a QD under equilibrium conditions, including a bleach of the first exciton transition and the appearance of a quantum-confined, low-energy intraband absorption feature. Photoelectron spectroscopy confirms that Ag acts as a p-type dopant for PbSe QDs and infrared spectroscopy is consistent with k·p calculations of the size-dependent intraband transition energy. We find that to bleach the first exciton transition by an average of 1 carrier per QD requires that approximately 10% of the Pb be replaced by Ag. We hypothesize that the majority of incorporated Ag remains at the QD surface and does not interact with the core electronic states of the QD. Instead, the excess Ag at the surface promotes the incorporation of <1% Ag into the QD core where it causes p-type doping behavior.
Combining Gradual Deformation and Upscaling Techniques for Direct Conditioning of Fine Scale Reservoir Models to Dynamic Data (2001)

Abstract Integration of dynamic data typically requires the solution of an inverse problem that can be computationally intensive and practically infeasible for fine scale reservoir models. In this paper we present a new methodology to directly update fine scale geostatistically-based reservoir models by combining gradual deformation parameterization for the fine scale geostatistical model and an upscaling technique for the coarse scale flow simulation model. The proposed methodology includes: Perturbation of the fine scale geostatistical model using the gradual deformation parameterization. Gradual deformation ensures the preservation of the overall geostatistical properties of the fine model. Generation of the coarse scale flow simulation model by upscaling the fine scale geostatistical model. Sensitivity computation of the flow simulation results with respect to the fine scale parameterization. This sensitivity computation is analytical and takes into account the upscaling process. Direct updating of the fine scale geostatistical model using classical optimization process. Direct updating ensures consistency between the fine and coarse scale models. The accuracy of the proposed methodology was improved by calibrating the flow simulation model. The objective of this calibration is to reduce the error introduced by the upscaling step during the flow simulation. We applied successfully our methodology for fine scale reservoir description by integrating permanent down-hole gauge measurements directly into a three-dimensional geostatistical model containing about two million grid blocks. This test is designed to highlight several key issues of the proposed methodology: Efficiency of the upscaling step coupled with gradient-based optimization to speed up the history matching process. Usefulness of the calibration step for a correct integration of upscaling techniques in history matching. Capability of the methodology for maintaining consistency and coherency between fine scale and coarse scale models. Improvement of the reservoir characterization by integrating dynamic data at the fine geostatistical scale. We conclude that the proposed methodology can be used effectively and efficiently for reservoir characterization purposes.
GPU friendly fast Poisson solver for structured power grid network analysis (2009)

In this paper, we propose a novel simulation algorithm for large scale structured power grid networks. The new method formulates the traditional linear system as a special two-dimension Poisson equation and solves it using an analytical expressions based on FFT technique. The computation complexity of the new algorithm is O(NlgN), which is much smaller than the traditional solver's complexity O(N1.5) for sparse matrices, such as the SuperLU solver and the PCG solver. Also, due to the special formulation, graphic process unit (GPU) can be explored to further speed up the algorithm. Experimental results show that the new algorithm is stable and can achieve 100X speed up on GPU over the widely used SuperLU solver with very little memory footprint.
Plate Orientation Effect on the Inductance of Multi-Layer Ceramic Capacitors (2007)

Various multi-layer ceramic capacitor (MLCC) geometries with horizontally and vertically oriented plates are modeled to determine the equivalent series inductance. It shows that the plate stack location and dimensions (independent of plate orientation) are the most significant factors affecting the inductance.
An intelligent question answering conversational agent using Na&#x00EF;ve Bayesian classifier (2012)

In the current scenario, learning has taken a completely new dimension. New methods of teaching like E-learning and collaborative learning etc have computerized the learning process to a large extent. But the teachers' presence is still mandatory at all times. Also the current systems have low reliability so the teacher has to monitor them constantly. To solve this problem this paper introduces an automated question answering system. This proposed system answers the queries posted by the student in a more interactive way like a virtual teacher (chatbot system). The Q&A knowledge base can be accessed and modified by the instructor who could also know the areas where the students are more prone to doubts thus helping the student as well as the instructor.