gebhart/patrepeval huggingface dataset:
Laser-Perforated Membranous Biomaterials Induced Pore Size-Dependent Bone Induction When Used as a New BMP Carrier (2003)

Previously we found that laser perforation of a collagen membrane (35 w m thickness, Koken Co., Tokyo) produced an effective bone morphogenetic protein (BMP) carrier, if the created pore sizes were larger than 0.5 mm. In this study we applied the same technique to create pores of 0.2 and 1.0 mm in a thicker (1.2 mm thickness) porous biodegradable membrane made of polylactic acid and an l -caprolactone copolymer (PLA-CL) to obtain an effective membranous BMP carrier with higher mechanical strength. Pieces of PLA-CL (0.5 2 1.0 2 0.12 cm) combined with rhBMP-2 (5 w g) were implanted subcutaneously into rats and processed for analyses at 1-3 weeks. The laser-perforated PLA-CL membranes equipped with 1.0 mm pores induced mineralization beginning from the margins of the pores judging from the X-ray patterns, but bone formation seemed to proceed irregularly inside the pores. In the perforated PLA-CL membrane with 1.0-mm pores bone formation did not significantly increase compared with the nonperforated one. This was due to the fact that the PLA-CL membrane was already a porous structure (85% porosity). In contrast with laser-perforated PLA-CL 0.2 mm pores, bone was induced on the collagen fibers and fiber bundles inside the pores. The different patterns of bone formation between the PLA-CL membranes with 1.0 and 0.2 mm pores seemed to be related to the active formation of perpendicular collagen fibers through the 0.2 mm pores.
Development of MEMS Capacitive Sensor Using a MOSFET Structure (2008)

The concept of a capacitive MOSFET sensor using a SOI wafer for detecting vertical force applied to its floating gate was already reported by the authors. A MOSFET is fabricated on a SOI wafer, and the box oxide under the gate is removed to release the gate structure. This sensor detects the displacement of the movable gate electrode from changes in drain current, and this current can be amplified electrically by adding voltage to the gate, i.e., the MOSFET itself serves as a mechanical sensor structure. Following this, the present paper reports the fabrication of a practical test device and its preliminary characterization. The present paper also proposes a circuitry, which converts the drain current change to the voltage change while compensating the temperature change. The performance of this circuitry is confirmed by SPICE simulation. In accelerometer application, a comparatively heavy proof mass and thin supporting beams are necessary for increasing the sensitivity. For this purpose, a fabrication process of depositing a thick mass structure using electroplating is newly proposed.
VISUAL GENERALIST WITH VISUAL SPECIALIST PHYTOPHAGOUS INSECTS: HOST SELECTION BEHAVIOUR AND APPLICATION TO MANAGEMENT (1978)

Our findings suggest that Hoplocampa testudinea adults (apparently monophagous) and Rhagoletis pomonella flies (oligophagous) are more specific in orientation to hue and/or form of feeding, mating, or oviposition sites on a common host (apple) than are Lygus lineolaris adults (polyphagous) on apple. We speculate that subject to varying influence by host plant chemical stimuli, many monophagous – oligophagous insects may tend to be visual specialists in comparison with polyphagous insects, especially those polyphagous species whose preferred feeding, mating, or oviposition sites within an individual plant are of diverse physical characteristics. They may tend more toward being visual generalists. Visual traps incorporating the synthetic equivalents of comparatively specific host plant visual stimuli should prove useful in monitoring and possibly even directly controlling a number of monophagous‐oligophagous insects on crops. RÉSUMÉ INSECTES PHYTOPHAGES GÉNÉRALISTES VISUELS ET SPÉCIALISTES VISUELS: COMPORTEMENT DE CHOIX DE LA PLANTE‐HÔTE ETAPPLICATION DANS LA LUTTE On montre que les adultes de Hoplocampa testudinea (apparemment monophages) et de Rhagoletis pomonella (oligophages) sont plus positivement spécifiques visuellement dans leur orientation suivant la teinte et/ou la forme de leurs lieux d'alimentation, de copulation et de ponte sur un hôte commun (le pommier) que les adultes de Lygus lineolaris (polyphages) sur le pommier. On émet l'hypothèse que de nombreux insectes monophages‐oligophages peuvent avoir tendance à être des spécialistes visuels si on les compare aux insectes polyphages, en particulier aux espèces polyphages dont les lieux favoris d'alimentation, de copulation et de ponte ont des caractéristiques physiques diverses. Il se peut qu'ils aient plutôt tendance à être des généralistes visuels. Des pièges visuels incorporant les équivalents synthétiques de stimuli visuels relativement spécifiques de la plante‐hôte seraient utiles pour surveiller et éventuellement détruire un certain nombre d'insectes monophages‐oligophages dans les cultures.
Electrospinning Applications in Bioengineering: Fabrication of Bio-Engineered Skeletal Muscle (2001)

Abstract The objective of this study is to develop a skeletal muscle prosthetic composed entirely of natural or otherwise bioresorbable materials that recapitulates the structure and function of intact muscle. in our fabrication strategy we begin by electrospinning (see Mathews et al., this volume) a hollow, cylindrical fascial sheath composed of poly-glycolic acid (PGA), poly-lactic acid (PLA), Type I collagen microfibers or a blend of these materials (figure 1). The resulting fascial sheath is a highly porous fabric composed of interwoven fibers that range from less than 1 micron to 2-5 microns in diameter (patents pending). Next, we isolate neonatal rat skeletal myoblasts by enzymatic dissociation. The dissociated tissue is subjected to an interval of differential adhesion to enrich the preparation in skeletal muscle myoblasts. The final cell pellet of myoblasts is then suspended at high density in Type I collagen. This suspension is polymerized at 37°C for 10-15 minutes and used to fill a fascial sheaths (patents pending).
Production and Comparison of Peptide Siderophores from Strains of Distantly Related Pathovars of <i>Pseudomonas syringae</i> and <i>Pseudomonas viridiflava</i> LMG 2352 (2000)

The production of peptide siderophores and the variation in siderophore production among strains of Pseudomonas syringae and Pseudomonas viridiflava were investigated. An antibiose test was used to select a free amino acid-containing agar medium favorable for production of fluorescent siderophores by two P. syringae strains. A culture technique in which both liquid and solid asparagine-containing culture media were used proved to be reproducible and highly effective for inducing production of siderophores in a liquid medium by the fluorescent Pseudomonas strains investigated. Using asparagine as a carbon source appeared to favor siderophore production, and relatively high levels of siderophores were produced when certain amino acids were used as the sole carbon and energy sources. Purified chelated siderophores of strains of P. syringae pv. syringae, P. syringae pv. aptata, P. syringae pv. morsprunorum, P. syringae pv. tomato, and P. viridiflava had the same amino acid composition and spectral characteristics and were indiscriminately used by these strains. In addition, nonfluorescent strains of P. syringae pv. aptata and P. syringae pv. morsprunorum were able to use the siderophores in biological tests. Our results confirmed the proximity of P. syringae and P. viridiflava; siderotyping between pathovars of P. syringae was not possible. We found that the spectral characteristics of the chelated peptide siderophores were different from the spectral characteristics of typical pyoverdins. Our results are discussed in relation to the ecology of the organisms and the conditions encountered on plant surfaces.
Efficient isolation of highly purified tonsil B lymphocytes using RosetteSep with allogeneic human red blood cells (2009)

RosetteSep reagent can be used in combination with allogeneic human red blood cells to reproducibly isolate tonsil B lymphocytes to high levels of purity with no change in phenotype or loss of cells. This method provides considerable time and cost savings compared to other methods.
Continuous Time Models (2002)

In the case of discrete time system models, the stochastic case hardly amounts to more than introducing an extra sample point argument into each of the variables in the problem.
Proximity-Aware Traffic Routing in Distributed Fog Computing Platforms (2019)

Container orchestration engines such as Kubernetes do not take into account the geographical location of application replicas when deciding which replica should handle which request. This makes them ill-suited to act as a general-purpose fog computing platforms where the proximity between end users and the replica serving them is essential. We present proxy-mity, a proximity-aware traffic routing system for distributed fog computing platforms. It seamlessly integrates in Kubernetes, and provides very simple control mechanisms to allow system administrators to address the necessary trade-off between reducing the user-to-replica latencies and balancing the load equally across replicas. proxy-mity is very lightweight and it can reduce average user-to-replica latencies by as much as 90% while allowing the system administrators to control the level of load imbalance in their system.
Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation (1994)

Central nervous system midline cells constitute a discrete group of Drosophila embryonic cells with numerous functional and developmental roles. Corresponding to their separate identity, the midline cells display patterns of gene expression distinct from the lateral central nervous system. A conserved 5 base pair sequence (ACGTG) was identified in central nervous system midline transcriptional enhancers of three genes. Germ-line transformation experiments indicate that this motif forms the core of an element required for central nervous system midline transcription. The central nervous system midline element is related to the mammalian xenobiotic response element, which regulates transcription of genes that metabolize aromatic hydrocarbons. These data suggest a model whereby related basic-helix-loop-helix-PAS proteins interact with asymmetric E-box-like target sequences to control these disparate processes.
Discrete wavelet transform-based multivariate exploration of tissue via imaging mass spectrometry (2008)

Mass spectral imaging (MSI) or imaging mass spectrometry is a developing technology that combines spatial information with traditional mass spectrometry. It enables researchers to study the spatial distribution of biomolecules such as proteins, peptides, and metabolites throughout organic tissue sections. MSI has particular merit in exploratory settings where there is no prior hypothesis of relevant target molecules. It is rapidly becoming a potent exploratory instrument for tissue biomarker studies.
Synthesis, characterization, and kinetics studies of organic soluble photosensitive copolyimide (1989)

Abstract A copolyimide synthesized from 3,3′,4,4′‐benzophenone tetracarboxylic dianhydride, 3,5‐diaminobenzoic acid, and 2,3,5,6‐tetramethyl‐ p ‐phenylene diamine was found to be soluble in N ‐alkyl substituted amides. An organic soluble photosensitive polyimide was obtained by further reaction of the copolyimide with methacrylic acid glycidyl ester. After adding Michler's ketone, the UV spectra absorbance near 360 nm of the copolyimide decreased rapidly upon the irradiation of mercury lamp. Using benzoic acid and methacrylic acid glycidyl ester as model compounds and N, N ‐dimethylbenzylamine as catalyst, the mechanism of reaction between the carboxylic group of the copolyimide and epoxy group of methacrylic acid glycidyl ester in N ‐methyl‐2‐pyrrolidone was found to have two competitive reactions, namely the auto‐catalytic and the catalytic reactions. The apparent rate constants of each reaction were determined. Comparison of apparent rate constants between the model compound and the polymer reaction system are also reported.
An investigation of whether agonist‐selective receptor conformations occur with respect to M<sub>2</sub> and M<sub>4</sub> muscarinic acetylcholine receptor signalling <i>via</i> G<sub>i/o</sub> and G<sub>s</sub> proteins (2005)

1. A range of muscarinic acetylcholine (mACh) receptor agonists (methacholine (MCh), oxotremorine-M (OXO-M), oxotremorine (OXO), arecoline (AREC), bethanechol (BETH), pilocarpine (PILO)) have been investigated with respect to their binding to, and activation of, M(2) and M(4) mACh receptors, recombinantly expressed in Chinese hamster ovary cells, to explore the possibility that these agonists may differentially affect mACh receptor-G(i/o) and -G(s) coupling. 2. M(2)/M(4) mACh receptor coupling to the adenylyl cyclase/cyclic AMP signalling pathway has been explored in intact cells. G(i/o)-mediated negative coupling to adenylyl cyclase was explored functionally by assessing the ability of the mACh receptor agonists to inhibit forskolin-stimulated enzymic activity. Following pertussis toxin treatment (100 ng ml(-1), 18-20 h) to inactivate G(i/o) proteins, each agonist caused a G(s)-mediated enhancement of forskolin-stimulated adenylyl cyclase activity. 3. At both M(2) and M(4) mACh receptors, all agonists tested were more potent in mediating G(i/o)- versus G(s)-coupled responses. This difference (determined as the pIC(50) (G(i/o) coupling) minus pEC(50) (G(s) coupling) value) was greatest for AREC (65-75-fold) and least for BETH and PILO (</=10-fold). 4. Using apparent binding affinities (pK(B)), and potency (EC(50)/IC(50)) and responsiveness (E(max)/I(max)) estimates, relative efficacy (e(rel)) values for each agonist with respect to M(2) and M(4) mACh receptor coupling to G(i/o)- and G(s)-mediated signalling were also calculated. While the e(rel) values obtained for MCh and OXO-M in CHO-m2 cells were similar, OXO-M behaved as a 'super-agonist' at the M(4) mACh receptor giving greater e(rel) values for both G(i/o) and G(s) coupling relative to MCh. 5. The experimental data indicate that while interesting differences between agonists with respect to M(2)/M(4) mACh receptor activation and receptor-G(i/o) and -G(s) coupling can be discerned, no clear examples of agonist trafficking of signal have emerged.
Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India (2006)

There is a regional variation in the prevalence of azoospermia and oligozoospermia in the male partners of infertile couples from different regions of India. The prevalence of azoospermia in Kurnool and Jodhpur is higher than any other worldwide reported literature. Further studies need to be carried out to determine the cause of this.
Historias de poder, de traición, de corrupción... (2007)

Del fondo de su historia periodistica y aun personal, Julio Scherer Garcia ha sacado y engarzado las historias que componen su nuevo libro, fiel a la estirpe de otros suyos, invaluables, enlazados del primero al mas reciente por un hilo conductor inequivoco: el obsesivo afan del autor por desnudar los abusos del poder y de sus beneficiarios. La terca memoria revela precisamente lo que su titulo describe con exactitud: la poderosa decision del fundador de Proceso de no olvidar. Julio Scherer Garcia fue aun mas alla. Recurrio al mecanismo insolito que el define como el acto de reportear los recuerdos, para precisar datos, evocar fechas, afilar el arpon con el que escribe. Como otros de sus muchos trabajos periodisticos, este libro –editado por Grijalbo– esta inevitablemente destinado a provocar polemica, por no decir iracundia. En adelanto exclusivo, ofrecemos en estas paginas algunos fragmentos del volumen, en particular aquel que el autor dedica a Jorge Hank Rhon, uno de los mas preclaros cachorros de la corrupcion mexicana
Effeets of marijuana extract and tetrahydrocannabinol on electroencephalographic sleep patterns (1976)

Marijuana extract, given in daily doses containing 70 to 210 mg delta-9-tetrahydrocannabinol (THC), induced effects on sleep that were virtually identical to those produced by the same doses of relatively pure (96%) THC. Both drugs reduced eye movements density with some tolerance developing to this effect. Stage 4 tendend to increase with drug administration. Abrupt withdrawal led to extremely high densities of eye movement, increased rapid eye movement (REM) durations, and a sharp but transient fall in stage 4 to baseline levels. These effects may be useful in the elucidation of the pharmacology of sleep. The effects on sleep of THC administration (but not withdrawal) closely resemble those induced by lithium. For this reason, we suggest further studies of THC in affective disorders. Evidence available thus far suggests that THC produces dysphoric symptoms in unipolar but not in bipolar depressed patients; these differences in response may prove of diagnostic value. An adequate therapeutic trial of THC in bipolar depressed patients has not yet been carried out.
Ultrashallow p<sup>+</sup>/n Junction Formation by 0.5–1 keV Ion Implantation (1998)

We have evaluated the electrical characteristics and the secondary ion mass spectroscopy(SIMS) depth profile of an ultrashallow junction formed by the 0.5-1 keV boron implantation method. The modeling of the boron profile was performed using the Monte Carlo method for an as-implanted profile and the computationally efficient method for transient enhanced diffusion. A junction depth of less than 300Å can be obtained by rapid thermal annealing at 900°C for B implantation at 0.5 keV. In the case of annealing at 1000°C, the junction depths were approximately 500–550Å for both 0.5 keV and 1 keV. For the same equivalent energy, the junction depth of BF 2 is shallower than that of boron after annealing. For an ultrashallow junction, HF dipping prior to rapid thermal annealing causes a significant loss of dopant and high sheet resistance.
Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin (2001)

The development of adrenergic sensitivity in nociceptors has been suggested as a mechanism of neuropathic pain. We sought to determine if nociceptors in the skin of normal subjects exhibit adrenergic sensitivity. We investigated the effects of intradermal administration of norepinephrine, phenylephrine, and brimonidine on heat pain sensitivity. Norepinephrine and phenylephrine (in concentrations ranging from 0.1 to 10 microM by factors of 10), brimonidine (at 0.01-1 microM), and saline were injected (30 microl volume) in a random, double-blind manner to different sites on the volar surface of the forearm in ten subjects. Before and after the injections, heat testing was performed with a non-contact laser thermal stimulator. Heat pain threshold was measured by means of a 'Marstock' technique in which subjects pressed a reaction time key when they perceived that a slowly increasing heat stimulus (1 degrees C/s ramp from a 36 degrees C base) was painful. In addition, the subjects used magnitude estimation techniques to rate the intensity of pain to a suprathreshold heat stimulus (47 degrees C, 2 s). Mechanical testing was done using 200-microm diameter probes attached to calibrated weights that provided forces over the range of 16-512 mN. The intradermal injections of norepinephrine, phenylephrine and brimonidine produced little evoked pain. However, a dose-dependant decrease in heat pain threshold, but not mechanical pain threshold, was observed. At the highest drug dose injected, all three adrenergic compounds produced a significant decrease in heat pain threshold compared to the saline injection. A significant increase in response to the suprathreshold heat stimulus was also found. One possible explanation for this apparent heat hyperalgesia is that the decrease in perfusion due to the localized vasoconstriction may alter the heat response. However, in control studies we found that the non-adrenergic vasoconstrictors, angiotensin II and vasopressin did not produce heat hyperalgesia at doses that produced comparable decreases in blood flow. In addition, occlusion of blood flow with a blood pressure cuff did not lead to heat hyperalgesia. Thus, the heat hyperalgesia observed with the adrenergic agonists is not due to a decrease in perfusion associated with the injection. These results indicate that alpha(1)- and alpha(2)-adrenoceptor-mediated mechanisms may play a role in sensitization of nociceptors to heat stimuli in normal skin.
Épigraphie et paléographie (1955)

Robert Louis. Épigraphie et paléographie. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 99ᵉ année, N. 2, 1955. pp. 195-222.
Glass bead purification of plasmid template DNA for high throughput sequencing of mammalian genomes (2002)

To meet the new challenge of generating the draft sequences of mammalian genomes, we describe the development of a novel high throughput 96-well method for the purification of plasmid DNA template using size-fractionated, acid-washed glass beads. Unlike most previously described approaches, the current method has been designed and optimized to facilitate the direct binding of alcohol-precipitated plasmid DNA to glass beads from alkaline lysed bacterial cells containing the insoluble cellular aggregate material. Eliminating the tedious step of separating the cleared lysate significantly simplifies the method and improves throughput and reliability. During a 4 month period of 96-capillary DNA sequencing of the Rattus norvegicus genome at the Baylor College of Medicine Human Genome Sequencing Center, the average success rate and read length derived from >1 800 000 plasmid DNA templates prepared by the direct lysis/glass bead method were 82.2% and 516 bases, respectively. The cost of this direct lysis/glass bead method in September 2001 was approximately 10 cents per clone, which is a significant cost saving in high throughput genomic sequencing efforts.
Catheterizing a Tortuous Ureter (1988)

A technique is described that has proved successful for stenting tortuous and dilated ureters. This method is invaluable for introducing guide wires before ureteroscopy and for stone manipulation or ureteral stenting before extracorporeal shock wave lithotripsy.
Enhance load balancing using Flexible load sharing in cloud computing (2015)

Cloud computing is a popular design pattern for the large and distributed data centers. In the distributed environment, load balancing of the nodes and task scheduling is the main concern for the designers. This article presents a Flexible load sharing algorithm (FLS) which introduce the third function. The third function makes partition the system in to domain. This function is helpful for the selection of other nodes which are present in the same domain. By applying the flexible load sharing to the particular domains in to the distribute system, the performance can be improved when any node is in overloaded situation.
Invited paper. Power-factor correction in single-phase switching-mode power supplies—an overview (1994)

The importance of power-factor correction and the related line-harmonics reduction is increasing as the amount of line-fed electronic equipment grows and the requirements of regulatory agencies tighten. This paper presents a comprehensive overview of power-factor correction in single-phase off-line switching-mode power supplies, including the definition of power factor and its relation to total harmonic distortion; the IEC 555-2 requirements; many passive and active power-factor corrector topologies and control methods; modelling issues; and practical considerations.