gebhart/patrepeval huggingface dataset:
Aerosolized deferoxamine prevents lung and systemic injury caused by smoke inhalation (1994)

We assessed the role of oxidant release at the airway mucosal surface on airway injury and systemic response to a severe smoke insult. Adult sheep (n = 20) were insufflated with well-characterized smoke from burning cotton toweling. A standardized dose of 12 breaths of smoke with a tidal volume of 20 ml/kg was given under anesthesia. Sheep were awakened, monitored for 24 h, and killed; data were compared with control sheep. Sheep were given 1) humidified oxygen, 2) continuous aerosol of 10% deferoxamine (DFO)-pentastarch solution beginning after smoke, 3) DFO-alone aerosol, or 4) pentastarch-alone aerosol. DFO has antioxidant properties directly and chelates iron. Severe respiratory failure occurred in all but DFO-pentastarch group. Shunt fraction increased from a control of 4%. Histological assessment revealed severe airway mucosal edema, ulceration, bronchorrhea, and severe atelectasis but only moderate alveolar edema. Increased lipid peroxides were also noted in free airway fluid and in bronchoalveolar lavage fluid. In addition, oxygen consumption increased by 75%, fluid requirements increased threefold, and protein-rich systemic soft tissue lymph flow doubled, all significant increases compared with control sheep. No significant physiological or histological changes were noted in DFO-pentastarch aerosol group. We conclude that 1) oxidants possibly initiated through free iron release are involved in severe smoke-induced airway injury and resulting systemic inflammatory response, probably through an amplified oxidant injury and 2) an aerosol of a DFO-pentastarch complex prevents the injury process, whereas DFO alone is not effective as an aerosol.
Dose optimization of gallium chloride, orally administered, in combination with platinum compounds. (1995)

An individual dose adaptation for cisplatin (CDDP), etoposide and gallium chloride (GaCl3) was proposed to improve the efficacy of this combination chemotherapy and avoid its toxicity. A clinical study was performed in 28 non small cell lung cancer patients, to verify this hypothesis. CDDP and etoposide were administered as continuous infusions every 3 weeks and GaCl3 orally during and between the CDDP-etoposide sequential infusions. CDDP doses were adjusted to achieve, during each 5 day infusion, an area under the total plasma platinum concentrations versus time curve (AUC Pt 0-120) ranging between 80,000 and 100,000 micrograms/l.h. Etoposide dosages were 120 mg/24 h during days 1-3 of the CDDP infusion. GaCl3 dosages were adjusted to obtain plasma gallium (Ga) concentrations ranging between 200 and 400 micrograms/l. The proposed methods of adaptation were successful from a pharmacokinetic point of view as AUC Pt 0-120 were respectively 81351 +/- 4788, 88268 +/- 8451 and 88331 +/- 8778 micrograms/l.h during the first 3 courses, and plasma Ga concentrations, determined during the 2nd and 3rd CDDP courses, 16 hours after the beginning of the CDDP infusion, were respectively 264 +/- 127 and 313 +/- 186 micrograms/l. However, these results were not pharmacodynamically successful and the therapeutic window was not confirmed. Past clinical trials with GaCl3 will be reviewed, as well as the factors which modify the pharmacokinetics or the pharmacodynamic effects of CDDP and GaCl3. From this review, an optimal dosage of 400 mg GaCl3 could be proposed to potentiate a combination chemotherapy with a platinum compound. The target AUC of the platinum compound should be the AUC avoiding its cumulative toxicity.
Packaging of Endogenous Retroviral Sequences in Retroviral Vectors Produced by Murine and Human Packaging Cells (1998)

Interaction of retrovirus vectors and endogenous retroviruses present in packaging cell lines and target cells may result in unwanted events, such as the formation of recombinant viruses and the mobilization of therapeutic vectors. Using sensitive reverse transcriptase PCR assays, we investigated human and murine gene therapy packaging cell lines for incorporation of endogenous retrovirus transcripts into murine leukemia virus (MLV) vector particles and, conversely, whether vector genomes are incorporated into human endogenous retrovirus (HERV) particles. VL30 endogenous retrovirus sequences were efficiently packaged in particles produced by the murine AM12 packaging system. For every seven MLV-derived beta-galactosidase (beta-Gal) vector genomes present in the particles, one copy of VL30 was also packaged. Although human FLY packaging cells expressed several classes of HERV transcripts (HERV-K, HuRT, type C, and RTVL-H), none was detectable in the MLV vector particles released from the cells. Nonspecific packaging of the MLV Gag-Pol expression vector transcripts was detected in the FLY virions at a low level (1 in 17,000 sequences). These findings indicate that human packaging cells produce retrovirus particles far less contaminated by endogenous viral sequences than murine packaging cells. Human teratocarcinoma cells (GH cells), which produce HERV-K particles, were transduced with an MLV-derived beta-Gal vector. Although both HERV-K and RTVL-H sequences were found in association with the particles, beta-Gal transcripts were not detected, indicating that HERV Gag proteins do not efficiently package MLV-based vectors.
A SCADA Intrusion Detection Framework that Incorporates Process Semantics (2016)

SCADA security is an increasingly important research area as these systems, used for process control and automation, are being exposed to the Internet due to their use of TCP/IP protocols as a transport mechanism for control messages. Most of the existing research work on SCADA systems has focused on addressing SCADA security by monitoring attacks or anomalies at the network level. The main issue affecting these systems today is that by focusing our attention on network-level monitoring needs, security practitioners may remain unaware of process level constraints. The proposed framework helps ensure that a mechanism is in place to help map process level constraints, as described by process engineers, to network level monitoring needs. Existing solutions have tried to address this problem but have not been able to fully bridge the gap between the process and the network. The goal of this research is to provide a solution that (i) leverages the knowledge process engineers have about the system (to help strengthen cyber security) and that has the ability to (ii) seamlessly monitors process constraints at the network level using standard network security tools. A prototype system for the Modbus TCP protocol and the Bro IDS has been built to validate the approach.
Development of self-pulsations due to self-annealing of proton bombarded regions during aging in proton bombarded stripe-geometry AlGaAs DH lasers grown by molecular beam epitaxy (1980)

Experimental observations indicate that the occurrence of optical self-pulsation in proton delineated stripe-geometry double-heterostructure junction lasers is related to the degree of gain guiding inherent in individual lasers. We show that an aging process occurs during lasing operation which has the effect of partially annealing the proton induced carrier removal concentration at the edges of the active stripe of the laser. In some lasers, the magnitude of this annealing effect is sufficiently large to flatten the active stripe carrier concentration profile thus reducing filament stability leading ultimately to optical self-pulsation. It is shown that the carrier concentration profile modification is due to the dual effects of decreasing the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n = 2</tex> nonradiative current component at the active stripe-proton bombarded interface as well as the geometric effect of increasing the laser active stripe width. This latter effect may be also responsible for some portion of laser threshold current increase observed during device operation.
Bramwell's Helicopter Dynamics (2001)

Since the original publication of Helicopter Dynamics by A.R.S. Bramwell in 1976, this book has become the definitive text on helicopter dynamics. As such it is an essential aid to those studying the behavior of helicopters. The second edition builds on the strengths of the original, and hence the approach of the first edition is retained. The authors provide a detailed summary of helicopter aerodynamics, stability, control, structural dynamics, vibration, and aeroelastic and aeromechanical stability.
Buffer Sizing for 802.11-Based Networks (2010)

We consider the sizing of network buffers in IEEE 802.11-based networks. Wireless networks face a number of fundamental issues that do not arise in wired networks. We demonstrate that the use of fixed-size buffers in 802.11 networks inevitably leads to either undesirable channel underutilization or unnecessary high delays. We present two novel dynamic buffer-sizing algorithms that achieve high throughput while maintaining low delay across a wide range of network conditions. Experimental measurements demonstrate the utility of the proposed algorithms in a production WLAN and a lab test bed.
<scp>H</scp> ong <scp>K</scp> ong Democracy Protests (2009)

Hong Kong democracy protests, and the democracy movement as a phenomenon, have their origins in the colonial period. As the debate on democracy continued into the post‐1997 period, when Hong Kong was faced with a series of challenges, both economic and political, the democracy movement gained new momentum. Democracy protests became part of Hong Kong people's lives, in the form of a mass rally held every year since July 1, 2003. These large‐scale protests of the 1980s and the post‐1997 period are historic milestones of the Hong Kong democracy movement, which has its origins in the 1980s when the 1997 Question emerged.
Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells. (1988)

Nerve growth factor (NGF) is known to increase the levels of neurofilament proteins in PC-12 pheochromocytoma cells. In this report, we show that the three neurofilament subunits, NF-L, NF-M, and NF-H, are not induced coordinately. NF-H accumulated only after longer term NGF treatment than required for NF-L and NF-M. While NGF treatment resulted in 12- and 14-fold increases in NF-L and NF-M mRNA levels, respectively, over a 14-day period, no increase in the level of NF-H mRNA was observed. This indicated that in PC-12 cells, control of NF-H expression by NGF may occur at the post-transcriptional level. NGF appeared to have no effect on the stability of NF-L mRNA, although it increased the stability of NF-M mRNA relative to that in control PC-12 cells. Analysis of the effect of NGF on the transcription of neurofilament genes showed 4- and 5-fold increases in the rates of NF-L and NF-M gene transcription, respectively, and no increase in the rate of NF-H gene transcription. Taken together these results demonstrate that NGF stimulates the expression of individual neurofilament subunits at the transcriptional and/or post-transcriptional levels.
The nickel oxide electrode. Part 1. (1955)

G. W. D. Briggs, E. Jones and W. F. K. Wynne-Jones, Trans. Faraday Soc., 1955, 51, 1433 DOI: 10.1039/TF9555101433
Cardiac Regeneration using Growth Factors: Advances and Challenges (2016)

Myocardial infarction is the most significant manifestation of ischemic heart disease and is associated with high morbidity and mortality. Novel strategies targeting at regenerating the injured myocardium have been investigated, including gene therapy, cell therapy, and the use of growth factors. Growth factor therapy has aroused interest in cardiovascular medicine because of the regeneration mechanisms induced by these biomolecules, including angiogenesis, extracellular matrix remodeling, cardiomyocyte proliferation, stem-cell recruitment, and others. Together, these mechanisms promote myocardial repair and improvement of the cardiac function. This review aims to address the strategic role of growth factor therapy in cardiac regeneration, considering its innovative and multifactorial character in myocardial repair after ischemic injury. Different issues will be discussed, with emphasis on the regeneration mechanisms as a potential therapeutic resource mediated by growth factors, and the challenges to make these proteins therapeutically viable in the field of cardiology and regenerative medicine. Resumo O infarto do miocárdio representa a manifestação mais significativa da cardiopatia isquêmica e está associado a elevada morbimortalidade. Novas estratégias vêm sendo investigadas com o intuito de regenerar o miocárdio lesionado, incluindo a terapia gênica, a terapia celular e a utilização de fatores de crescimento. A terapia com fatores de crescimento despertou interesse em medicina cardiovascular, devido aos mecanismos de regeneração induzidos por essas biomoléculas, incluindo angiogênese, remodelamento da matriz extracelular, proliferação de cardiomiócitos e recrutamento de células-tronco, dentre outros. Em conjunto, tais mecanismos promovem a reparação do miocárdio e a melhora da função cardíaca. Esta revisão pretende abordar o papel estratégico da terapia, com fatores de crescimento, para a regeneração cardíaca, considerando seu caráter inovador e multifatorial sobre o reparo do miocárdio após dano isquêmico. Diferentes questões serão discutidas, destacando-se os mecanismos de regeneração como recurso terapêutico potencial mediado por fatores de crescimento e os desafios para tornar essas proteínas terapeuticamente viáveis no âmbito da cardiologia e da medicina regenerativa.
PARENCHYMAL CELLS FROM ADULT RAT LIVER IN NONPROLIFERATING MONOLAYER CULTURE (1973)

Parenchymal cells from adult rat liver have been established in primary monolayer culture. Donor animals are subjected to a partial hepatectomy and, 4 days later, cells are prepared by collagenase perfusion of the regenerated liver. The hepatic parenchymal cells, separated from nonparenchymal material and suspended in serum-free medium, are placed in plastic tissue culture dishes, where they form a monolayer within 24 h. The monolayer cells exhibit minimal mitotic activity and demonstrate several major metabolic functions characteristic of liver in vivo; these include albumin synthesis and secretion, gluconeogenesis from 3-carbon precursors, responsiveness to insulin and glucagon, glycogen synthesis, and activity of two microsomal enzymes. These functions are present in the monolayer cells for several days at activities similar to those observed in the liver in vivo. The findings indicate that hepatic parenchymal cells in this monolayer system are viable and behave in many respects like normal adult rat liver.
Coherent Lensless imaging with Ultra-Broadband Light Sources (2013)

We demonstrate a method for efficient lensless imaging using ultra-broadband light sources. By using a pair of time-delayed, coherent pulses in a Fourier-transform scheme, spectrally resolved diffraction patterns are obtained throughout the entire spectrum of the incident light source. We perform a proof-of-principle experiment using an octave-spanning visible light source, and obtain images of a holographic test sample with near-diffraction limited resolution. Our approach provides a promising route towards efficient high-resolution imaging using table-top high-harmonic soft-X-ray sources.
Perivascular Adipose Tissue and Coronary Vascular Disease (2014)

Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capable of producing local factors with the potential to augment coronary vascular tone, inflammation, and the initiation and progression of coronary artery disease. The purpose of the present review is to outline previous findings about the cardiovascular effects of coronary perivascular adipose tissue and the potential mechanisms by which adipose-derived factors may influence coronary vascular function and the progression of atherogenesis.
FRuG: A benchmark for packet forwarding in future networks (2010)

The ossification of Internet infrastructure and protocols have hindered the advancement of itself. GENI, AKARI and several other similar initiatives are pushing forward to overcome this hindrance. They facilitate researchers with networking platforms dedicated for innovative networking experiments. In these virtualized platforms, researchers can define their own forwarding schemes which can be radically different from the existing solutions. However, neither researchers nor the vendors are endowed with benchmarks to evaluate their new schemes. In this paper we introduce a Flexible Rule Generator, FRuG, an entirely user controlled benchmarking tool for evaluating future packet forwarding algorithms. With FRuG, rule generation does not need to be restricted to a fixed number of fields anymore, which makes it highly generic. It allows the user to select the protocol fields and the distribution of each field, which can either be defined by the user or configured to follow the distribution of an input seed file. The user has the complete control over the structure and the size of the rule table which makes it a powerful benchmark to assess various packet forwarding algorithms and for different types of routers (ex. edge routers, core routers, etc.). FRuG consists of an IPv4 prefix analyzer and generator, MAC address analyzer and generator, and a generic rule generator. We believe that FRuG will be a very useful tool to the networking research community with the paradigm shifts in networking like network virtualization, which takes packet forwarding to a completely new level. FRuG is an opensource tool freely available at http://sites.google.com/site/thilangane/research.
A comparative study of location-based recommendation systems (2017)

Abstract Recent advancements in location-based recommendation system (LBRS) and the availability of online applications, such as Twitter, Instagram, Foursquare, Path, and Facebook have introduced new research challenges in the area of LBRS. Use of content, such as geo-tagged media, point location-based, and trajectory-based information help in connecting the gap between the online social networking services and the physical world. In this article, we present a systematic review of the scientific literature of LBRS and summarize the efforts and contributions proposed in the literature. We have performed a qualitative comparison of the existing techniques used in the area of LBRS. We present the basic filtration techniques used in LBRS followed by a discussion on the services and the location features the LBRS utilizes to perform the recommendations. The classification of criteria for recommendations and evaluation metrics are also presented. We have critically investigated the techniques proposed in the literature for LBRS and extracted the challenges and promising research topics for future work.
Automatic Retraction and Full-Cycle Operation for a Class of Airborne Wind Energy Generators (2015)

Airborne wind energy systems aim to harvest the power of winds blowing at altitudes higher than what conventional wind turbines reach. They employ a tethered flying structure, usually a wing, and exploit the aerodynamic lift to produce electrical power. In the case of ground-based systems, where the traction force on the tether is used to drive a generator on the ground, a two-phase power cycle is carried out: one phase to produce power, where the tether is reeled out under high traction force, and a second phase where the tether is recoiled under lower load. The problem of controlling a tethered wing in this second phase, the retraction phase, is addressed here, by proposing two possible control strategies. Theoretical analyses, numerical simulations, and experimental results are presented to show the performance of the two approaches. Finally, the experimental results of complete autonomous power generation cycles are reported and compared with those in first-principle models.
Algebraic reconstruction techniques can be made computationally efficient (positron emission tomography application) (1993)

Algebraic reconstruction techniques (ART) are iterative procedures for recovering objects from their projections. It is claimed that by a careful adjustment of the order in which the collected data are accessed during the reconstruction procedure and of the so-called relaxation parameters that are to be chosen in an algebraic reconstruction technique, ART can produce high-quality reconstructions with excellent computational efficiency. This is demonstrated by an example based on a particular (but realistic) medical imaging task, showing that ART can match the performance of the standard expectation-maximization approach for maximizing likelihood (from the point of view of that particular medical task), but at an order of magnitude less computational cost.
Next Generation Sequencing Identifies Five Major Classes of Potentially Therapeutic Enzymes Secreted by<i>Lucilia sericata</i>Medical Maggots (2016)

Lucilia sericata larvae are used as an alternative treatment for recalcitrant and chronic wounds. Their excretions/secretions contain molecules that facilitate tissue debridement, disinfect, or accelerate wound healing and have therefore been recognized as a potential source of novel therapeutic compounds. Among the substances present in excretions/secretions various peptidase activities promoting the wound healing processes have been detected but the peptidases responsible for these activities remain mostly unidentified. To explore these enzymes we applied next generation sequencing to analyze the transcriptomes of different maggot tissues (salivary glands, gut, and crop) associated with the production of excretions/secretions and/or with digestion as well as the rest of the larval body. As a result we obtained more than 123.8 million paired-end reads, which were assembled de novo using Trinity and Oases assemblers, yielding 41,421 contigs with an N50 contig length of 2.22 kb and a total length of 67.79 Mb. BLASTp analysis against the MEROPS database identified 1729 contigs in 577 clusters encoding five peptidase classes (serine, cysteine, aspartic, threonine, and metallopeptidases), which were assigned to 26 clans, 48 families, and 185 peptidase species. The individual enzymes were differentially expressed among maggot tissues and included peptidase activities related to the therapeutic effects of maggot excretions/secretions.
V-vector algebra and its application to Volterra-adaptive filtering (1999)

In this paper, we describe a new algebraic structure called V-vector algebra, which is a formal basis for the development of Volterra-adaptive filter algorithms as an extension of linear-adaptive techniques. In this way, fast and numerically stable adaptive Volterra filtering algorithms can be easily derived from the known linear theory. V-vector algebra can also be applied to deal with linear multichannel filters with channels of different memory lengths. A reformulation of the Lee-Mathews fast recursive least squares (RLS) algorithm and a new fast and stable Givens rotation-based square root RLS algorithm, both derived using V-vector algebra, are finally presented.