gebhart/patrepeval huggingface dataset:
Obesity, inflammatory markers, and endometrial cancer risk: a prospective case–control study (2010)

Obesity, a major risk factor for endometrial cancer, is a low-grade inflammatory state characterized by elevated concentrations of cytokines and acute phase reactants. The current study had two aims: first to investigate the associations of C-reactive protein (CRP), interleukin 6 (IL6), and IL1 receptor antagonist (IL1Ra) with endometrial cancer risk and second to examine to which extent these markers can influence the association between obesity and endometrial cancer. We conducted a case-control study, nested within the European Prospective Investigation into Cancer and Nutrition, which comprised 305 incident cases of endometrial cancer and 574 matched controls. CRP, IL6, and IL1Ra were measured in prospectively collected blood specimens by immunoassays. Data were analyzed using conditional logistic regression. All statistical tests were two-sided, and P values <0.05 were considered statistically significant. We observed a significant increase in risk of endometrial cancer with elevated levels of CRP (odds ratio (OR) for top versus bottom quartile: 1.58, 95% confidence interval (CI): 1.03-2.41, P(trend)=0.02), IL6 (OR for top versus bottom quartile: 1.66, 95% CI: 1.08-2.54, P(trend)=0.008), and IL1Ra (OR for top versus bottom quartile: 1.82, 95% CI: 1.22-2.73, P(trend)=0.004). After adjustment for body mass index (BMI), the estimates were strongly reduced and became non-significant. The association between BMI and endometrial cancer was also substantially attenuated (∼10-20%) after adjustment for inflammatory markers, even when the effects of C-peptide or estrone had already been taken into account. We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu.
Ultra-low voltage high-speed Schmitt trigger circuit in SOI MOSFET technology (2007)

This paper proposes a novel ultra-low voltage and high speed Schmitt trigger circuit designed in silicon-on-insulator (SOI) technology. The proposed circuit is designed using dynamic threshold MOS (DTMOS) technique and multi-threshold voltage CMOS (MT-CMOS) technique to reduce power consumption and accomplish high speed operation. The experiment shows the proposed Schmitt trigger circuit consumes 4.68µW at 0.7V power supply voltage and the circuit demonstrates the maximum switching speed of 170psec.
Enzyme Inhibitors. V. The Syntheses of 6-Substituted-(9-hydroxyalkyl)purines and Their Evaluation as Inhibitors of Adenosine Deaminase<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme Inhibitors. V. The Syntheses of 6-Substituted-(9-hydroxyalkyl)purines and Their Evaluation as Inhibitors of Adenosine Deaminase*Howard J. Schaeffer and Parmatma S. BhargavaCite this: Biochemistry 1965, 4, 1, 71–76Publication Date (Print):January 1, 1965Publication History Published online1 May 2002Published inissue 1 January 1965https://pubs.acs.org/doi/10.1021/bi00877a013https://doi.org/10.1021/bi00877a013research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Incomplete Desorption of Liquid Excipients Reduces the <i>in Vitro</i> and <i>in Vivo</i> Performance of Self-Emulsifying Drug Delivery Systems Solidified by Adsorption onto an Inorganic Mesoporous Carrier (2012)

The purpose of the current study was to provide a mechanistic basis for in vitro and in vivo performance differences between lipid-based formulations solidified by adsorption onto a high surface area material and their respective liquid (i.e., nonadsorbed) counterparts. Two self-emulsifying formulations (based on either medium-chain or long-chain lipids) of the poorly water-soluble drug danazol were solidified by adsorption onto Neusilin US2. Liquid and adsorbed lipid-based formulations were subjected to in vitro dispersion-digestion tests, and additional in vitro experiments were performed to elucidate the cause of performance differences. The bioavailability of danazol after oral administration to rats was also assessed. The percentage of the dose solubilized in the aqueous phase during in vitro dispersion-digesting was ∼35% lower for the adsorbed formulations when compared to their liquid counterparts. This trend was also reflected in vivo, where the bioavailability of danazol after administration of the adsorbed formulations was ∼50% lower than that obtained after administration of the equivalent liquid formulation. Incomplete desorption of the microemulsion preconcentrate from the carrier on dispersion-digestion was identified as the main contributor to the reduced pharmaceutical performance of the adsorbed formulations. The results of the current study indicate that solidification of lipid-based formulations through adsorption onto a high surface area carrier may limit formulation (and drug) release in vivo and thereby reduce oral bioavailability.
ELECTRICAL CONTROL OF HOLOGRAPHIC STORAGE IN STRONTIUM-BARIUM NIOBATE (1969)

Single-crystal Sr0.75Ba0.25Nb2O6 when used in conjunction with an externally applied electric field is shown to be a sensitive volume holographic medium capable of high-resolution information storage. Optically induced refractive index changes of 5 × 10−4 have been observed with laser exposure of 14 J/cm2. A simple relation between the applied electric field and optical exposure is determined which allows electrical control of optically induced refractive index change. In addition to control of the optically induced effect it is found that the applied electric field can also be used to control the diffraction efficiency of the holographic reconstruction process.
Dephenolization of industrial wastewaters catalyzed by polyphenol oxidase (1984)

A new enzymatic method for the removal of phenols from industrial aqueous effluents has been developed. The method uses the enzyme polyphenol oxidase which oxidizes phenols to the corresponding o-quinones; the latter then undergo a nonenzymatic polymerization to form water-insoluble aggregates. Therefore, the enzyme in effect precipitates phenols from water. Polyphenol oxidase has been found to nearly completely dephenolize solutions of phenol in the concentration range from 0.01 to 1.0 g/L. The enzymatic treatment is effective over a wide range of pH and temperature; a crude preparation of polyphenol oxidase (mushroom extract) is as effective as a purified, commercially obtained version. In addition to phenol itself, polyphenol oxidase is capable of precipitating from water a number of substituted phenols (cresols, chlorophenols, naphthol, etc.). Also, even pollutants which are unreactive towards polyphenol oxidase can be enzymatically coprecipitated with phenol. The polyphenol oxidase treatment has been successfully used to dephenolize two different real industrial waste-water samples, from a plant producing triarylphosphates and from a coke plant. The advantage of the polyphenol oxidase dephenolization over the peroxidase-catalyzed one previously elaborated by the authors is that the former enzyme uses molecular oxygen instead of costly hydrogen peroxide (used by peroxidase) as an oxidant.
Cardiac resynchronization therapy in heart failure patients: an update. (2009)

Heart failure continues to be a major public health problem with high morbidity and mortality rates, despite the advances in medical treatment. Advanced heart failure patients have severe persistent symptoms and a poor quality of life. Cardiac resynchronization therapy (CRT), an invasive therapy which involves synchronized pacing of both right and left ventricles, improves ventricular conduction delay and left ventricular performance. Several clinical trials of CRT in medically refractory heart failure patients with wide QRS (> 120 ms), left ventricular ejection fraction <or=35% and New York Heart Association (NYHA) class III and IV have shown improved quality of life, NYHA class, left ventricular ejection fraction and reduced mortality. About 30% of heart failure patients who receive CRT do not respond to treatment. Mechanical dyssynchrony may play a role in identifying patients who may respond better to CRT treatment. However, recent large scale clinical trials PROSPECT and RethinQ have challenged this concept. The role of CRT in heart failure patients with narrow QRS (< 120 ms), NYHA class I and II, atrioventricular nodal ablation in patients with atrial fibrillation and triple site pacing are evolving. Our review discusses the current evidence, indications, upcoming trials and future directions.
Front Cover, Volume 41, Issue 5 (2020)

Front Cover: The cover image is based on the Research Article FANCL gene mutations in premature ovarian insufficiency by Yajuan Yang et al., https://doi.org/10.1002/humu.23997.
Crystal Structure of the <i>Staphylococcus aureus</i> pI258 CadC Cd(II)/Pb(II)/Zn(II)-Responsive Repressor (2005)

The Staphylococcus aureus plasmid pI258 cadCA operon encodes a P-type ATPase, CadA, that confers resistance to the heavy metals Cd(II), Zn(II), and Pb(II). Expression of this heavy-metal efflux pump is regulated by CadC, a homodimeric repressor that dissociates from the cad operator/promoter upon binding of Cd(II), Pb(II), or Zn(II). CadC is a member of the ArsR/SmtB family of metalloregulatory proteins. Here we report the X-ray crystal structure of CadC at 1.9 angstroms resolution. The dimensions of the protein dimer are approximately 30 angstroms by 40 angstroms by 70 angstroms. Each monomer contains six alpha-helices and a three-stranded beta-sheet. Helices 4 and 5 form a classic helix-turn-helix motif that is the putative DNA binding region. The alpha1 helix of one monomer crosses the dimer to approach the alpha4 helix of the other monomer, consistent with the previous proposal that these two regulatory metal binding sites for the inducer cadmium or lead are each formed by Cys-7 and Cys-11 from the N terminus of one monomer and Cys-58 and Cys-60 of the other monomer. Two nonregulatory metal binding sites containing zinc are formed between the two antiparallel alpha6 helices at the dimerization interface. This is the first reported three-dimensional structure of a member of the ArsR/SmtB family with regulatory metal binding sites at the DNA binding domain and the first structure of a transcription repressor that responds to the heavy metals Cd(II) and Pb(II).
Reaktive Träger auf der Basis von Polyethylenimin zur Immobilisierung von Enzymen (1981)

Abstract Reactive slightly basic carriers with isothiocyanato and azido groups, which are able to bind enzymes covalently, could be obtained by reaction of crosslinked and uncrosslinked poly‐(ethyleneimine) with 4‐nitrophenyl isothiocyanate, 4‐nitrophenyl isocyanate, or ethyl chloroacetate, respectively, and subsequent reactions. The binding ability of the carriers for papain, trypsin, α‐chymotrypsin, and urease in dependence of the content of reactive groups and in the case of urease as function of the amount of offered enzyme was investigated. To characterize the immobilized enzymes some properties as enzymatic activity, storage stability, and stability after repeated application were determined.
CHILD HYGIENE (1931)

CHILD HYGIENE Richard A. Bolt CopyRight https://doi.org/10.2105/AJPH.21.7.815 Published Online: August 29, 2011
Nanofibrous and Graphene-Templated Conjugated Microporous Polymer Materials for Flexible Chemosensors and Supercapacitors (2015)

Conjugated microporous polymers (CMPs) are usually obtained as amorphous or semicrystalline powders. Their insolubility and nonprocessability are considered as key bottlenecks that impede CMP applications. In this study, light-emitting, nanofibrous films were fabricated by electrospinning CMP/poly(lactic acid) (PLA) mixtures. The resulting nanofibrous films show a high flexibility combined with high porosity and surface-area-to-volume ratios. The CMP-based nanofibrous films have been used as sensitive sensors in the detection of nitroaromatic and benzoquinone vapors as well as oxidizing metal ions. Moreover, 4-iodophenyl-substituted graphene sheets were used as templates for growing CMP/graphene sandwiches. The graphene-based CMP (G-CMP) sandwiches are characterized by high surface areas and aspect ratios. Furthermore, hierarchically porous two-dimensional carbon nanosheets were obtained by pyrolysis of these carbon-rich G-CMP hybrids. The resulting carbon nanomaterials show excellent supercapacitor behavior with a 48% increased capacitance if compared to porous carbons without the graphene template.
The schema evolution and data migration framework of the environmental mass database IMIS (2004)

This paper describes a framework that supports the simultaneous evolution of object-oriented data models and relational schemas with respect to a tool-supported object-relational mapping. The proposed framework accounts for non-trivial data migration induced by type evolution from the outset. The support for data migration is offered on the level of transparent data access. The framework consists of the following integrated parts: an automatic model change detection mechanism, a generator for schema evolution code and a generator for data migration APIs. The framework has been concepted in the IMIS project. IMIS is an information system for environmental radioactivity measurements. Though the indicated domain especially demands a solution like the one discussed in this paper, the achievements are of general purpose for multi-tier system architectures with object-relational mapping.
INVISIBLE NURSES (2002)

Tempe, AZ Editor's note: Our intent is to represent the gender, age, and ethnic diversity of nursing in AJN ’s images and editorial, and we continually struggle to achieve this goal. However, it should be noted that, by your count, about 10% of the images in AJN ’s August issue were of men—more than representative of the actual proportion of male nurses.
ML Fitting of Mixture Models (2000)

This chapter contains sections titled: Introduction ML Estimation Information Matrices Asymptotic Covariance Matrix of MLE Properties of MLEs for Mixture Models Choice of Root Test for a Consistent Root Application of EM Algorithm for Mixture Models Fitting Mixtures of Mixtures Maximum a Posteriori Estimation An Aitken Acceleration-Based Stopping Criterion Starting Values for EM Algorithm Stochastic EM Algorithm Rate of Convergence of the EM Algorithm Information Matrix for Mixture Models Provision of Standard Errors Speeding up Convergence Outlier Detection from a Mixture Partial Classification Partial Nonrandom Classification Classification ML Approach
Polymorphism and intersolubility of some palmitic, stearic and oleic triglycerides: PPP, PSP and POP (1986)

Abstract The polymorphism and intersolubility of a series of palmitic, stearic and oleic triglycerides have been investigated in order to understand the thermal properties of fractions of natural fats. Results are shown for tripalmitin (PPP), 2‐stearo‐dipalmitin, (PSP) and 2‐oleo‐dipalmitin (POP); these molecules differ essentially in the number of carbons (P→S) and the degree of unsaturation of chains (S→O). The different polymorphic forms have been verified by variable temperature X‐ray powder diffraction. The organization of the fatty acid carbon chains in the most stable polymorphic form (β′ or β) has been studied by variable temperature NMR spectroscopy by means of the protons relaxation times T 1 , T 2 and T 1ϱ . The construction of binary phase diagrams (PPP‐PSP and PPP‐POP), from the data obtained by differential scanning calorimetry and X‐ray powder diffraction, shows the formation of solid solutions or monotectic interactions, according to the nature and the polymorphic form of the triglycerides. The kinetic of the very important β′→β transition has been analyzed by variable temperature powder X‐ray diffraction for PPP, and [PPP‐PSP] or [PPP‐POP] blends. The molecular interactions occurring between the mixed crystals have been explained, by applying the model of Avrami and by an empirical isolation method.
Genes for Asthma? An Analysis of the European Community Respiratory Health Survey (1997)

Besides environmental triggers, a family history of asthma is a strong risk factor for the development of asthma in offspring. The pooled data from 13,963 interviews of randomly selected, 20 to 48 yr-old participants from the 30 centers of the European Community Respiratory Health Survey (ECRHS) were analyzed with conventional logistic regression and a Class A regressive model adapted for the segregation of various transmission modes in families. The asthma prevalence in the interviewed index generation was 6.9% (95% confidence interval [CI]: 6.5 to 7.3), and in the parent generation was 6.1% (5.8 to 6.4). As with asthma prevalence, the risk of a subject having asthma if a parent had asthma also had a large geographic variation across the survey centers. The mean risk if a father had asthma was 2.9 (2.4 to 3.5), and If the mother had asthma was 3.2 (2.6 to 3.9). The risk increased to 7.0 (3.9 to 12.7) if both parents were affected. For developing extrinsic asthma, extrinsic asthma in any parent was a greater risk factor (4.9 [3.9 to 6.0]) than intrinsic asthma of the parent (1.5 [0.8 to 2.6]), and the risk for women was slightly higher than that for men (4.3 [3.3 to 5.5] versus 3.6 [2.6 to 5.0]). Applying different segregation models, only a model for a two-allele gene with a codominant inheritance could not be rejected, assuming a major gene with a population frequency of 24.2%. Further results make a multilocus/threshold model likely. In conclusion, a history of asthma in parents is a strong risk factor for asthma in the offspring. Under the assumptions of the applied segregation analysis, at least one major gene exists which could be a gene involved also in allergy. However, asthma is not fully described by a single-gene model. The risk for asthma varies within the European countries, and should be seen in the context of a complex genetic and environmental pathophysiology.
Physical Aging in Polymer Glasses (1995)

Physical aging refers to structural relaxation of the glassy state toward the metastable equilibrium amorphous state, and it is accompanied by changes in almost all physical properties. These changes, which must be taken into account in the design, manufacture, and use of glassy polymer materials and devices, present a daunting challenge to theorists.
Use of pet food-grade poultry by-product meal as an alternate protein source in weanling pig diets (2004)

Three experiments were conducted to evaluate pet food-grade poultry by-product meal (PBM) as a replacement protein source for fish meal (FM), blood meal (BM), and spray-dried plasma protein (SDPP) in weanling pig diets. In the first study, 200 crossbred pigs (initial BW = 6.5 kg) were weaned (21 d) and randomly allotted to one of four dietary treatments, which included a control and three test diets where PBM was substituted for FM, blood products, or both. Experimental diets were fed during Phase I (d 0 to 5 postweaning) and Phase II (d 5 to 19), and a common Phase III diet was fed from d 19 to 26. Overall (d 0 to 26), there was no difference in performance of pigs fed PBM in place of the other ingredients. However, during Phase I, BW (P < 0.05), ADG (P < 0.02), and intake (P < 0.001) in pigs fed diets containing SDPP were greater than those fed diets with PBM. In Exp. 2, the performance of pigs (n = 100, initial BW = 6.5 kg) fed diets containing 20% PBM (as-fed basis, replacing SDPP, BM, FM, and a portion of the soybean meal) in all phases of the nursery diet was compared with a group fed conventional diets without PBM. There were no differences in overall performance (d 0 to 26); however, ADG (P < 0.10) and feed intake were higher (P < 0.01) for pigs fed the conventional diet than for pigs fed the 20% PBM diet during Phase I (d 0 to 5). Experiment 3 was a slope-ratio assay to determine the ability of PBM to replace SDPP. A total of 320 pigs (initial BW = 7.32 kg) was weaned (21 d) and allotted to five treatment groups in three trials in a blocked design with product (SDPP or PBM) as the first factor, and lysine level (1.08, 1.28, 1.49%; as-fed basis) as the second factor. Growth rate increased with increasing lysine (P < 0.05), regardless of the source. These results indicate that PBM can be used in nursery diets in place of blood meal and fish meal without affecting performance. Furthermore, although feeding PBM in Phase I diets was not equivalent to SDPP during the first week, there was no overall difference in performance at the end of the nursery phase.
Monoclonal Antibody Characterization of Plasmodium Falciparum Antigens (1984)

We characterized a set of eight monoclonal antibodies produced against Plasmodium falciparum. In an indirect fluorescent antibody assay the antibodies produced small dots of fluorescence in schizonts and individual merozoites. This merozoite-associated dot reactivity occurred with 21 different strains of P. falciparum, but there was no reactivity with other human, nonhuman primate, or rodent Plasmodium species. Three of the monoclonal antibodies precipitated proteins of Mr 145,000, 135,000, and 104,000. Five of the monoclonal antibodies precipitated proteins of Mr 78,000, 63,000, 42,000, and 40,000.
Method to make paraffin‐embedded breast and lymph tissue mimic fresh tissue in DNA analysis (1996)

Determination of DNA ploidy has been found to be of diagnostic and prognostic value with regard to many solid tumors. Flow cytometric analysis of DNA ploidy is dependent on the binding of fluorescent dyes to DNA. Preserving cell morphology by fixing the tissue in formalin interferes with the binding of propidium iodide (PI) and other fluorescent dyes to DNA. This distortion of DNA content measurement can cause inaccuracies in DNA-ploidy determinations of formalin-fixed tissue specimens and precludes the use of appropriate DNA standards. Therefore, it has been impossible to determine accurately the DNA ploidy of formalin-fixed, paraffin-embedded (FFPE) tissues. Using formalin-fixed cells as a model for FFPE cells, we developed a thermal treatment method to reverse the effect of formalin on the binding of propidium iodide to DNA. Applying this approach to the preparation of FFPE lymph node and breast tissue for DNA analysis, we have developed a method that makes the binding of PI to the DNA of FFPE tissue mimic that of fresh tissue. Following dewaxing, rehydration, and trypsin treatment, the FFPE tissue, resuspended in PBS, was heated to 75°C for 90 min to restore the PI binding to that of fresh cells. This method makes it possible to use fresh, DNA-diploid cells as an internal control and, thus, determine more accurately the DNA ploidy of tumors reserved in formalin and paraffin. © 1996 Wiley-Liss, Inc.
Inhaled Zanamivir for the Prevention of Influenza in Families (2000)

When combined with the treatment of index cases, prophylactic treatment of family members with once-daily inhaled zanamivir is well tolerated and prevents the development of influenza. In this study there was no evidence of the emergence of resistant influenza variants.