gebhart/patrepeval huggingface dataset:
A New Synthesis of Cyclic Ketones<sup>1</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Synthesis of Cyclic Ketones1Herbert O. House and Harry BabadCite this: J. Org. Chem. 1963, 28, 1, 90–92Publication Date (Print):January 1, 1963Publication History Published online1 May 2002Published inissue 1 January 1963https://pubs.acs.org/doi/10.1021/jo01036a020https://doi.org/10.1021/jo01036a020research-articleACS PublicationsRequest reuse permissionsArticle Views365Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Properties of 2‐oleodipalmitin, 2‐elaidodipalmitin and some of their mixtures (1971)

Abstract The glycerides 2‐oleodipalmitin (POP) and 2‐elaidodipalmitin (PEP) were synthesized and their melting behavior and dilatometric properties were determined. Three mixtures of POP with PEP were examined. Five polymorphs of POP and four of PEP were identified by x‐ray diffraction patterns. Rates of transformation of the lower melting polymorphs were, in general, quite rapid at temperatures just below their melting points. But transformation of unseeded POP to its highest melting form was slow and required several days at a temperature just below melting. Coefficients of expansion were determined for the highest melting polymorph and the liquid form of each triglyceride. Melting dilation was determined for the highest melting polymorph. Mixtures of POP with PEP exhibited different melting ranges depending on the tempering procedures and the composition, but even quickly‐solidified mixtures tempered without melting to the highest melting range as they were slowly heated over a period of 2 hr. Slow cooling from the melt essentially segregated the components.
Microcantilever-based platforms as biosensing tools (2010)

The fast and progressive growth of the biotechnology and pharmaceutical fields forces the development of new and powerful sensing techniques for process optimization and detection of biomolecules at very low concentrations. During the last years, the simplest MEMS structures, i.e. microcantilevers, have become an emerging and promising technology for biosensing applications, due to their small size, fast response, high sensitivity and their compatible integration into "lab-on-a-chip" devices. This article provides an overview of some of the most interesting bio-detections carried out during the last 2-3 years with the microcantilever-based platforms, which highlight the continuous expansion of this kind of sensor in the medical diagnosis field, reaching limits of detection at the single molecule level.
The motion of long bubbles in polygonal capillaries. Part 1. Thin films (1995)

Foam in porous media exhibits an unusually high apparent viscosity, making it useful in many industrial processes. The rheology of foam, however, is complex and not well understood. Previous pore-level models of foam are based primarily on studies of bubble flow in circular capillaries. A circular capillary, however, lacks the corners that characterize the geometry of the pores. We study the pressure–velocity relation of bubble flow in polygonal capillaries. A long bubble in a polygonal capillary acts as a leaky piston. The ‘piston’ is reluctant to move because of a large drag exerted by the capillary sidewalls. The liquid in the capillary therefore bypasses the bubble through the leaky corners at a speed an order higher than that of the bubble. Consequently, the pressure work is dissipated predominantly by the motion of the fluid and not by the motion of the bubble. This is opposite to the conclusion based on bubble flow in circular capillaries. The discovery of this new flow regime reconciles two groups of contradictory foam-flow experiments. Part 1 of this work studies the fluid films deposited on capillary walls in the limit Ca → 0 ( Ca ≡ μ U /σ, where μ is the fluid viscosity, U the bubble velocity, and σ the surface tension). Part 2 (Wong et al. 1995) uses the film profile at the back end to calculate the drag of the bubble. Since the bubble length is arbitrary, the film profile is determined here as a general function of the dimensionless downstream distance x . For 1 [Lt ] x [Lt ] Ca −1 , the film profile is frozen with a thickness of order Ca 2/3 at the centre and order Ca at the sides. For x ∼ Ca −1 , surface tension rearranges the film at the centre into a parabolic shape while the film at the sides thins to order Ca 4/3 . For x [Gt ] Ca −1 , the film is still parabolic, but the height decreases as film fluid leaks through the side constrictions. For x ∼ Ca −5/3 , the height of the parabola is order Ca 2/3 . Finally, for x [Gt ] Ca −5/3 , the height decreases as Ca 1/4 x −1/4 .
RHAMM Is a Centrosomal Protein That Interacts with Dynein and Maintains Spindle Pole Stability (2003)

The receptor for hyaluronan-mediated motility (RHAMM), an acidic coiled coil protein, has previously been characterized as a cell surface receptor for hyaluronan, and a microtubule-associated intracellular hyaluronan binding protein. In this study, we demonstrate that a subset of cellular RHAMM localizes to the centrosome and functions in the maintenance of spindle integrity. We confirm a previous study showing that the amino terminus of RHAMM interacts with microtubules and further demonstrate that a separate carboxy-terminal domain is required for centrosomal targeting. This motif overlaps the defined hyaluronan binding domain and bears 72% identity to the dynein interaction domain of Xklp2. RHAMM antibodies coimmunprecipitate dynein IC from Xenopus and HeLa extracts. Deregulation of RHAMM expression inhibits mitotic progression and affects spindle architecture. Structure, localization, and function, along with phylogenetic analysis, suggests that RHAMM may be a new member of the TACC family. Thus, we demonstrate a novel centrosomal localization and mitotic spindle-stabilizing function for RHAMM. Moreover, we provide a potential mechanism for this function in that RHAMM may cross-link centrosomal microtubules, through a direct interaction with microtubules and an association with dynein.
Differentiation of Arginine Vasopressin Antagonistic Effects by Selective V2 versus Dual V2/V1a Receptor Blockade in a Preclinical Heart Failure Model (2010)

Arginine vasopressin (AVP) is increased in patients with heart failure (HF). Its actions are linked to free water reabsorption (V2-) and arteriolar vasoconstriction (V1a receptor). AVP can exacerbate the cardiorenal syndrome with excess fluid retention and afterload increase. Tolvaptan (TOL; selective V2 antagonist) and Conivaptan (CON; dual V1a/V2 antagonist) are two AVP antagonists that counteract the action of AVP with distinct profiles. We investigated the therapeutic effects of CON and TOL in an acute HF model. Mongrel dogs were paced continuously at 220 beats/min. After 14 days, the animals underwent acute testing. Dogs were instrumented to measure cardiac output, blood pressure, pulmonary artery pressure, and left ventricular dP/dtmax. Additionally, during the acute experiments, vasopressin was infused intravenously (4 mU/kg/min) to achieve constant and controlled pathophysiological levels of AVP. Subsequently, animals received either CON or TOL (n = 6; 0.1-mg/kg bolus). There were no significant differences in effect on mean arterial pressure, dP/dtmax, central venous pressure, and urine output between CON and TOL. In contrast, cardiac output increased by 0.15 l/min after CON and decreased by 0.6 l/min after TOL (P < 0.01). Accordingly, the total peripheral resistance increased after TOL by 250 dyn*s/cm and decreased after CON by 125 dyn*s/cm (P < 0.01). In conclusion, it was demonstrated that in an acute HF model, CON lowered, whereas TOL increased afterload. The results suggest that dual V1a/V2 blockade in the acute HF setting could be beneficial compared with selective V2 blockade. Chronic experiments are needed to determine whether this finding can translate into a sustained clinical advantage.
New 2-Hydroxy Fatty Acids in the Caribbean Urchin Tripneustes esculentus (1994)

The novel alpha-hydroxy fatty acids 2-hydroxy-13-docosenoic acid [1a], 2-hydroxy-14-tricosenoic acid [2a], and 2-hydroxy-15-tetracosenoic acid [3a] were identified in the Caribbean urchin, Tripneustes esculentus. The double-bond positions of the novel alpha-hydroxy fatty acids were determined by derivatization with dimethyl disulfide and shown to correlate with the corresponding non-hydroxylated mono-unsaturated fatty acids, 13-docosenoic acid, 14-tricosenoic acid, and 15-tetracosenoic acid also present in T. esculentus. The total fatty acid composition of the urchins is also reported where cis-5-olefinic fatty acids such as 5,9-octadecadienoic acid and 5,11-eicosadienoic acid were found to predominate in the mixture. Cholesterol was the predominant sterol in T. esculentus.
Dependence of Thermal Conductivity of Carbon Black Filled Rubber on Several Factors (2009)

Five kinds of carbon black filled natural rubber were prepared, and thermal conductivity was studied considering two factors, which include temperature and volume percent of the filler. It was found that thermal conductivity had relevance to temperature and volume percent of carbon black, besides, structure and specific area of carbon black were also very important influencing factors. Moreover, reuniting phenomenon of nanometer grade of carbon black has much effect on thermal conductivity.
A Facile Interfacial Reaction Route To Prepare Magnetic Hollow Spheres with Tunable Shell Thickness (2008)

Magnetic Fe3O4 hollow spheres were successfully synthesized with a water in oil in water (W/O/W) emulsion. During the facile procedure, no high pressure, high temperature, or other complex reaction conditions were required. Transmission electric microscope (TEM) images showed that all the hollow structural products have a good spherical morphology with an average diameter of 160 nm. The average size and the size distribution were further determined with dynamic light scattering (DLS), which reveals that the hollow nanospheres have a narrow size distribution. The average size from DLS was about 180 nm, which approximated that from TEM data. X-ray diffraction (XRD) demonstrates that the products were all Fe3O4 phase without any impurity. By increasing or decreasing the dosage of precipitate and precipitant sources, we controlled the shell thickness successfully in the tens of nanometers range. The formation mechanism of those hollow magnetic nanospheres was discussed by using the "reverse micelle transport" mechanism.
Dichlorodimethylsilane as an anti-stiction monolayer for MEMS: a comparison to the octadecyltrichlorosilane self-assembled monolayer (2001)

This paper presents a quantitative comparison of the dichlorodimethylsilane (DDMS) monolayer to the octade-cyltrichlorosilane (OTS) self-assembled monolayer (SAM) with respect to the film properties and their effectiveness as anti-stiction coatings for micromechanical structures. Both coatings have been evaluated in several ways, including atomic force microscopy (AFM), contact angle analysis (CAA), work of adhesion by cantilever beam array (CBA) technique and coefficient of static friction using a sidewall testing device. While water and hexadecane contact angles are comparable, the DDMS coated microstructures exhibit higher adhesion than OTS coated ones. Furthermore, coefficient of static friction data indicate that the DDMS films are not as effective at lubrication as the OTS SAMs are, although both exhibit much improvement over chemical oxide. However, AFM data show that the samples which receive DDMS treatment accumulate fewer particles during processing than those which receive the OTS SAM treatment. The thermal stability of the DDMS film in air far exceeds the OTS SAM, as the DDMS remains very hydrophobic to temperatures upwards of 400/spl deg/C.
Structural Analysis of the Remote Performance Monitoring System Used in Modern Agricultural Machinery (2011)

The remote performance monitoring system used in modern agricultural machinery was proposed based on internet for the features of modern agricultural machinery such as complex, widely distributed, Poor working conditions, on-site performance monitoring being difficult and so on. The overall system structure and working principle was introduced emphasizing on the remote monitoring service center structure, the monitoring expert system structure and the reasoning technology of system.
Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants (2019)

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degenerative disease in adults and has also been proven to be a type of conformational disease associated with protein misfolding and dysfunction. To date, more than 150 distinct genes have been found to be associated with ALS, among which Superoxide Dismutase 1 <i>(SOD1)</i> is the first and the most extensively studied gene. It has been well-established that SOD1 mutants-mediated toxicity is caused by a gain-of-function rather than the loss of the detoxifying activity of SOD1. Compared with the clear autosomal dominant inheritance of SOD1 mutants in ALS, the potential toxic mechanisms of SOD1 mutants in motor neurons remain incompletely understood. A large body of evidence has shown that SOD1 mutants may adopt a complex profile of conformations and interact with a wide range of client proteins. Here, in this review, we summarize the fundamental conformational properties and the gained interaction partners of the soluble forms of the SOD1 mutants which have been published in the past decades. Our goal is to find clues to the possible internal links between structural and functional anomalies of SOD1 mutants, as well as the relationships between their exposed epitopes and interaction partners, in order to help reveal and determine potential diagnostic and therapeutic targets.
Dynamic Restoration of Large-Scale Distribution Network Contingencies: Crew Dispatch Assessment (2007)

The restoration of large-scale distribution outages is a very demanding task that involves considerable risk of human error. To help in this task, decision support systems have been developed based on network optimization. The optimization problem consists in proposing a set of switching operations together with an order to perform them. In this paper, we focus on the role of crew dispatch assessment in switching order optimality. We formulate the optimal operations sequencing problem as a dynamic programming problem and show how to include crew dispatch assessment to minimize energy not supplied. The proposed approach is compared with an approach for which crew dispatch assessment is neglected. Results on the comparison are given for a realistic 120 MVA substation outage.
Distinction of arrhythmias with the use of approximate entropy (2003)

Specialized therapies in the implantable cardioverter defibrillator (ICD) of antitachycardia pacing, low-energy cardioversion, and defibrillation can be used to treat ventricular tachycardia (VT) and ventricular fibrillation (VF) in a directed tiered approach. As devices improve, more advanced signal processing algorithms have been suggested to further refine the direction of therapy by first attempting lower energy therapies for VT, in order to minimize patient discomfort and battery depletion. The aim of this study is to further evaluate a complexity or regularity measure called approximate entropy for its ability to distinguish between morphologic regularity in VT and VF. High approximate entropy indicates irregularity, while low values indicate regularity. This measure has previously been used for heart rate variability quantification.
Symmetric Encryption in RFID Authentication Protocol for Strong Location Privacy and Forward-Security (2006)

RFID tag carries vital information in their operation and thus concerns on privacy and security issues do arise. The problem of traceability is critical in open radio frequency environments. An adversary can trace and interact with tag and this is referred as tracking. Nevertheless, with a strong authentication mechanism, uprising security problems in RFID systems can be solved. We had demonstrated current vulnerabilities and proposed our authentication mechanism to overcome them. As long as the secret information stays secret, tag forgery is not possible. Targeting RFID tag with short tag ID, we employ a resource friendly symmetric encryption scheme, which is a stream cipher building block to enhance the security features in active type RFID tag.
MiR-107 and MiR-185 Can Induce Cell Cycle Arrest in Human Non Small Cell Lung Cancer Cell Lines (2009)

We identified new cell cycle regulating miRNAs, miR-107 and miR-185, localized in frequently altered chromosomal regions in human lung cancers. Especially for miR-107, a large number of down-regulated genes are annotated with the gene ontology term 'cell cycle'. Our results suggest that these miRNAs may contribute to regulate cell cycle in human malignant tumors.
Biological Activity of Proinsulin and Related Polypeptides in the Fat Tissue (1973)

Abstract A number of insulin-like and proinsulin-like polypeptides were employed in the study of the structure-activity relationship of proinsulin. Glucose incorporation into CO2 and lipids, and the antilipolytic activity, were used as parameters to measure the biological activity of these polypeptides. The split proinsulin and the long A chain proinsulin, with 2 connecting amino acid residues, Arg-Arg, missing, have little more activity over that of native proinsulin. The long B chain proinsulin, with the absence of 2 connecting amino acid residues, Lys-Arg, has a 3- to 4-fold increase in activity compared to proinsulin. Further removal of amino acid residues from proinsulin molecule beyond Lys-Arg level can progressively increase proinsulin activity. These studies suggest that the decreased biological activity of proinsulin may be due essentially to the blocking of the A chain of insulin part in proinsulin molecule rather than the blocking of B chain. Insulin, with 1 or 2 arginine residues attached to COOH-terminal of B chain, loses 60% biological activity when compared to insulin molecule. The effect of positively charged groups may alter the insulin conformation or decrease the binding capacity between the insulin derivatives and the insulin receptor site, or both. C-peptide, a by-product in the proinsulin conversion to insulin, shows no insulin-like activity in homologous and heterologous fat tissues. No antagonistic or potentiating effect of C-peptide for insulin or proinsulin can be demonstrated in homologous and heterologous fat tissues. The feedback control of C-peptide on insulin or proinsulin action is not likely to exist in the adipose tissue.
Factors Associated With the Development of Motor Fluctuations and Dyskinesias in Parkinson Disease (2006)

Higher cumulative levodopa doses and higher cumulative levodopa equivalent doses (levodopa plus pramipexole) were associated with the earlier occurrence of motor complications. Motor fluctuations and dyskinesias appear to be interrelated because the presence of one is associated with the earlier development of the other.
Therapeutic Microinjection of Autologous Adult Human Neural Stem Cells and Differentiated Neurons for Parkinson's Disease: Five-Year Post-Operative Outcome (2009)

Object. Neural stem cell-derived neurons offer new cellular therapeutic alternatives for diseases of the central nervous system. Selective neural repair can be particularly valuable in progressive degenerative diseases with discrete cell loss, like Parkinson's disease. Some benefits were previously demonstrated following transplantation of fetal embryonic tissue. This approach, however, carries inherent risks of immunological reactions, infectious transmission, and intractable dyskinesias, in addition to serious ethical concerns. Methods. Cortical and subcortical tissue samples were obtained during neurosurgical procedures. Neural stem cells were isolated and expanded in vitro for several months. Safety, differentiation and functional studies were performed during the expansion phases. Nine months after harvesting, autologous cell suspensions containing differentiated dopaminergic and GABAergic neurons were microinjected unilaterally in a patient with advanced Parkinson's disease. 18F-dopa PET studies and neurological evaluations were performed serially (pre/post-operatively). Results. Over the next 36 months, the overall Unified Parkinson's Disease Rating Scale (UPDRS) improved by 81% while "on" medication and 83% while "off" medication. At five-years post-operatively, clinical motor scores returned to baseline. At three and twelve months post-operatively, 18F-dopa PET studies showed a 55.6% and 33.2% increase in dopamine uptake in the implanted left putamen. Conclusions. Adult neural stem cells derived from a patient's cerebral tissue can become a source of differentiated neurons, useful for grafting in the treatment of Parkinson's disease. The combined GABAergic and dopaminergic cells produced a long lasting motor improvement. This approach has the potential to make neural stem cell therapy acceptable and available to a large number of patients.
Interferometric, low thermal mass IR-absorber for thermal infrared detectors (1994)

The absorption efficiency of thermal infrared detectors of various designs is theoretically evaluated and compared, with an emphasis on detectors possible to fabricate by surface micromachining. In particular, the requirement of low thermal mass is considered. An absorber consisting of a single resistive metal film is shown to give a maximum of 50% absorptance. By backing such a film with a perfect reflector located at a λ/4 distance from it, nearly 100% absorptance can be attained in the broad wavelength range of 8-12μm. The simulations show that by adding a dielectric layer (membrane) onto the metal film, the absorptance remains nearly constant, provided that the proper values of nd, d1, Rs and d3 are chosen. For d1 = 0.2μm, the maximum variation in d3 and Rs, compatible with a decrease in mean absorptance from 100 to 95%, is 30 and 40%, respectively. If the dielectric film possesses absorptive behaviour the absorptance of the detector may still become large for previously selected structure parameters.
Ebusus, municipio flavio (1999)

En el presente articulo se analiza la inscripcion CIL ll 3663 = ERE 6. altamente
significativa en el dossier ebusitano. La lapida constituye en la actualidad el unico
testimonio de la promocion juridica de Ebusus en epoca flavia. En el nuevo municipium
Flavium se inserta la munificencia de los Cornelii, que repercutiria de forma notable en
la vida local. Proponemos fechar la inscripcion a fines del reinado de Domiciano o ya
bajo la dinastia de los Antoninos.