gebhart/patrepeval huggingface dataset:
A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites (2006)

Neutrophil NADPH oxidase plays a key role in host defense and in inflammation by releasing large amounts of superoxide and other ROSs. Proinflammatory cytokines such as GM-CSF and TNF-alpha prime ROS production by neutrophils through unknown mechanisms. Here we used peptide sequencing by tandem mass spectrometry to show that GM-CSF and TNF-alpha induce phosphorylation of Ser345 on p47phox, a cytosolic component of NADPH oxidase, in human neutrophils. As Ser345 is located in the MAPK consensus sequence, we tested the effects of MAPK inhibitors. Inhibitors of the ERK1/2 pathway abrogated GM-CSF-induced phosphorylation of Ser345, while p38 MAPK inhibitor abrogated TNF-alpha-induced phosphorylation of Ser345. Transfection of HL-60 cells with a mutated p47phox (S345A) inhibited GM-CSF- and TNF-alpha-induced priming of ROS production. This event was also inhibited in neutrophils by a cell-permeable peptide containing a TAT-p47phox-Ser345 sequence. Furthermore, ROS generation, p47phox-Ser345 phosphorylation, and ERK1/2 and p38 MAPK phosphorylation were increased in synovial neutrophils from rheumatoid arthritis (RA) patients, and TAT-Ser345 peptide inhibited ROS production by these primed neutrophils. This study therefore identifies convergent MAPK pathways on Ser345 that are involved in GM-CSF- and TNF-alpha-induced priming of neutrophils and are activated in RA. Inhibition of the point of convergence of these pathways might serve as a novel antiinflammatory strategy.
Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area (1995)

The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 children seen on each occasion. Differences in the efficacies were apparent with some nematodes 21 d after treatment, but these were no longer apparent 4 months after treatment, and by 6 months intensities of infection were similar to pre-treatment levels. These findings suggest that treatment of schoolchildren every 4 months may be necessary in this highly endemic area in order to have an impact on the intensity of intestinal nematode infections sufficient to be likely to reduce morbidity.
Reevaluating response and failure of medical treatment of endometriosis: a systematic review (2017)

Few studies of medical therapies for endometriosis report outcomes that are relevant to patients, and many women gain only limited or intermittent benefit from treatment.
Monte Carlo simulations of liquid alkyl ethers with the OPLS potential functions (1990)

Abstract Intermolecular potential functions have been developed for use in computer simulations of alkyl ethers. The simple OPLS model was adopted and parameterized to yield good descriptions of bimolecular and ion‐molecule complexes as well as to reproduce experimental thermodynamic properties of liquid ethers. The principal testing featured Monte Carlo statistical mechanics simulations for liquid dimethyl ether (DME), ethyl methyl ether (EME), diethyl ether (DEE), and tetrahydrofuran (THF). Average errors of 1–3% are obtained for the computed densities and heats of vaporization including results for THF at pressures up to 5000 atm. The torsional motion about the central CO bonds in EME and DEE was included in the simulations using rotational potential functions fit to results of molecular mechanics (MM2) calculations. The liquid‐state environment is found to have negligible effect on the conformational equilibria.
Μελέτη των θερμικών ανοιγμάτων της διπλής έλικας του DNA με προσομοιώσεις Monte Carlo (2009)

Η παρούσα εργασία μελετά τα θερμικά ανοίγματα της διπλής έλικας του βιοπολυμερούς DNA χρησιμοποιώντας προσομοιώσεις Monte Carlo σε θερμοκρασία 310 K. Οι υπολογισμοί βασίζονται στο φαινομενολογικό μοντέλο των Peyrand, Bishop και Dauxois καθώς και στον αλγόριθμο των Metropolis et al. Το πρώτο κεφάλαιο της εργασίας αφιερώνεται σε γενικές πληροφορίες γύρω από την δομή και τις λειτουργίες του γεννετικού υλικού. Επιπλέον περιέχει πληροφορίες γύρω από την μεταγραφή του DNA στα προκαρυωτικά κύτταρα. Επειδή σκοπός της εργασίας είναι η διερεύνηση της συσχέτισης μεταξύ μεγάλων θερμικών ανοιγμάτων και θέσεων του βακτηριακού DNA που εμφανίζουν βιολογική λειτουργία (σημεία πρόσδεσης της RNA-πολυμεράσης και διαφόρων βοηθητικών μεταγραφικών παραγόντων) σε διάφορους υποκινητές οπερονίων του βακτηρίου της E.coli, γίνεται μια πιο λεπτομερής συζήτηση για τον τρόπο με τον οποίο τα οπερόνια αυτά επιτυγχάνουν τον έλεγχο της εκφρασής τους. Το δεύτερο κεφάλαιο αναφέρεται στο θεωρητικό υπόβαθρο της εργασίας. Γίνεται μια εκτεταμένη συζήτηση γύρω από τις προσομοιώσεις Monte Carlo και πιο συγκεκριμένα του κριτηρίου των Metropolis et al. Στο ίδιο κεφάλαιο γίνεται παρουσίαση του μοντέλου των Peyrand, Bishop και Dauxois. Στο μοντέλο αυτό η δυναμική ενέργεια του συστήματος αποτελείται από δυο όρους. Ο ένας αναφέρεται στην αλληλεπίδραση μεταξύ των βάσεων ενός ζεύγους βάσης, ενώ ο άλλος στην αλληλεπίδραση μεταξύ των γειτονικών ζευγών βάσεων εξαιτίας της επικάλυψης των π μοριακών τροχιακών κάθε ζεύγους. Το μοντέλο επικεντρώνεται στον πιο προφανή βαθμό ελευθερίας του συστήματος: τη θερμικά ευαίσθητη (εξαιτίας των δεσμών υδρογόνου) απομάκρυνση μεταξύ των βάσεων ενός ζεύγους βάσης. Το τρίτο κεφάλαιο συγκροτείται από τα αποτελέσματα των υπολογισμών και τον σχολιασμό τους. Αρχικά παρουσιάζονται αποτελέσματα για απλούστερα συστήματα ταλαντωτών που αποτελούν οριακές περιπτώσεις του μοντέλου που περιγράφει το πρόβλημα των ανοιγμάτων της διπλής έλικας του DNA, όπως τα συστήματα των μονοδιάστατων ασύνδετων και συνδεδεμένων αρμονικών ταλαντωτών και το μονοδιάστατο σύστημα ανεξάρτητων ταλαντωτών Morse. Ακόμη παρουσιάζονται αποτελέσματα προσομοιώσεων σε τυχαίες αλληλουχίες DNA που δεν σχετίζονται με κανέναν υποκινητή. Το κύριο μέρος του κεφαλαίου αυτού αφιερώνεται στην παράθεση και στον σχολιασμό των αποτελεσμάτων των προσομοιώσεων για τους υποκινητές των τεσσάρων οπερονίων του βακτηρίου E.coli που εξετάστηκαν: της λακτόζης, της τρυπτοφάνης, της γαλακτόζης και της πρωτείνης recA. Επίσης εξετάζονται και οι υποκινητές των γονιδίων AdMLP και AAV P5 αδενοιών. Στο τελευταίο κεφάλαιο της εργασίας αυτής παρουσιάζονται τα συμπεράσματα που εξήχθησαν.
Sustained release of microbicides by newly engineered vaginal rings (2009)

The intravaginal rings described here are capable of efficacious drug delivery. Incorporation of several antiretroviral agents, including betulinol derivatives, which act at multiple levels of the HIV life cycle, may provide a synergistic effect to achieve higher efficacy on the inhibition of HIV infection.
Modeling, extraction and simulation of CMOS I/O circuits under ESD stress (2002)

A CAD tool set for VLSI CMOS I/O circuit design is developed. It includes a circuit simulator, a layout extractor and a substrate resistance solver. This paper presents a new layout extractor for CMOS I/O circuits and a new method for modeling the substrate resistance. With these tools, for the first time, full I/O circuits can be simulated accurately at the circuit-level with the substrate-coupling effects taken into consideration. The CAD tools are demonstratively applied to an industrial circuit.
Hormonal Regulation of α-Lactalbumin Secretion from Bovine Mammary Tissue Cultured in Vitro* (1983)

Hormonal control of α-lactalbumin secretion was studied in mammary tissue obtained from nonlactating multiparous Holstein cows pregnant approximately 8 months. Mammary explants were incubated for 72 h in medium containing insulin, T3 and various combinations or concentrations of PRL, cortisol, progesterone, 17β-estradiol, and GH. Concentrations ofα-lactalbumin in the medium and in homogenates of tissue were measured by RIA or sodium dodecyl sulfate-gel electrophoresis as an index of lactogenesis. Increasing quantities of PRL (25 to 100 ng/ml) progressively increased the release of α-lactalbumin into the medium, whereas concentrations of α-lactalbumin in explants exposed to PRL were similar to those in controls. Mammary explants exposed for 3 h to [3H]leucine plus PRL incorporated approximately 2, 11, and 18 times more label into α-lactalbumin 21–24, 45–48, and 69–72 h after initiation of culture, respectively, than explants cultured in the absence of PRL. Cortisol alone had no effect on α-lactalbumin secretion. However, the addition of PRL into medium containing cortisol increased α-lactalbumin secretion 2.4-fold over that of explants receiving PRL alone and 6.7-fold over that of explants receiving cortisol alone or control explants. Progesterone aloneincreased the secretion of α-lactalbumin approximately 2-fold over that in controls, but decreased PRL-induced α-lactalbumin secretion. 17β-Estradiol alone increased a-lactalbumin secretion over that in control explants and synergized with PRL to increase α-lactalbumin secretion. The addition of progesterone dramatically reduced the synergism between 17β-estradiol and PRL. GH had little effect on α-lactalbumin secretion. We conclude that PRL induces the synthesis and release of α-lactalbumin from mammary explantp of periparturient cows, and that cortisol and 17β-estradiol potentiate the lactogenic effects of PRL, provided progesterone is absent.
Direct synthesis of large area graphene on insulating substrate by gallium vapor-assisted chemical vapor deposition (2015)

A single layer of graphene with dimensions of 20 mm × 20 mm was grown directly on an insulating substrate by chemical vapor deposition using Ga vapor catalysts. The graphene layer showed highly homogeneous crystal quality over a large area on the insulating substrate. The crystal quality of the graphene was measured by Raman spectroscopy and was found to improve with increasing Ga vapor density on the reaction area. High-resolution transmission electron microscopy observations showed that the synthesized graphene had a perfect atomic-scale crystal structure within its grains, which ranged in size from 50 nm to 200 nm.
Bayesian fusion: Modeling and application (2013)

Bayesian statistics leads to a powerful fusion methodology, especially for the fusion of heterogeneous information sources. If fusion problems are handled under consideration of the full expressiveness and the full range of methods provided by Bayesian statistics, the Bayesian fusion methodology possesses an impressive wide range of applications. We discuss this by having a closer look at selected aspects of Bayesian modeling. Thereby, also parallels to other methods used for information fusion will be drawn. With regard to the practical tractability of Bayesian fusion problems, selected approaches to deal with its potentially high complexity are discussed.
Equilibrium Thermodynamic Studies in Water:  Reactions of Dihydrogen with Rhodium(III) Porphyrins Relevant to Rh−Rh, Rh−H, and Rh−OH Bond Energetics (2004)

Aqueous solutions of rhodium(III) tetra p-sulfonatophenyl porphyrin ((TSPP)Rh(III)) complexes react with dihydrogen to produce equilibrium distributions between six rhodium species including rhodium hydride, rhodium(I), and rhodium(II) dimer complexes. Equilibrium thermodynamic studies (298 K) for this system establish the quantitative relationships that define the distribution of species in aqueous solution as a function of the dihydrogen and hydrogen ion concentrations through direct measurement of five equilibrium constants along with dissociation energies of D(2)O and dihydrogen in water. The hydride complex ([(TSPP)Rh-D(D(2)O)](-4)) is a weak acid (K(a)(298 K) = (8.0 +/- 0.5) x 10(-8)). Equilibrium constants and free energy changes for a series of reactions that could not be directly determined including homolysis reactions of the Rh(II)-Rh(II) dimer with water (D(2)O) and dihydrogen (D(2)) are derived from the directly measured equilibria. The rhodium hydride (Rh-D)(aq) and rhodium hydroxide (Rh-OD)(aq) bond dissociation free energies for [(TSPP)Rh-D(D(2)O)](-4) and [(TSPP)Rh-OD(D(2)O)](-4) in water are nearly equal (Rh-D = 60 +/- 3 kcal mol(-1), Rh-OD = 62 +/- 3 kcal mol(-1)). Free energy changes in aqueous media are reported for reactions that substitute hydroxide (OD(-)) (-11.9 +/- 0.1 kcal mol(-1)), hydride (D(-)) (-54.9 kcal mol(-1)), and (TSPP)Rh(I): (-7.3 +/- 0.1 kcal mol(-1)) for a water in [(TSPP)Rh(III)(D(2)O)(2)](-3) and for the rhodium hydride [(TSPP)Rh-D(D(2)O)](-4) to dissociate to produce a proton (9.7 +/- 0.1 kcal mol(-1)), a hydrogen atom (approximately 60 +/- 3 kcal mol(-1)), and a hydride (D(-)) (54.9 kcal mol(-1)) in water.
The Preterit and Past Participle of Strong Verbs in Seventeenth-Century American English (1957)

AN EXAMINATION of certain American writings of the seventeenth century shows that the preterit and past participle of a number of strong verbs often varied considerably from the forms which are usual today. This result, of course, is not surprising, but the details are often interesting and I hope will justify their presentation here. The material examined includes approximately one thousand pages drawn from the following types of writing in the New England area between 1620 and 1700: history and narrative; writings on religious subjects; diaries; letters; writings of a legal character such as town records; and poetry. The verbs are listed alphabetically. The preterit forms will be considered first in this discussion.
The Design and Evaluation of a Hearing Aid with Trainable Amplification Parameters (2007)

In everyday listening situations, aid users can train this prototype aid to provide amplification parameters that, in such situations, they prefer significantly more often than untrained parameters prescribed and adjusted in a clinic. The preference for the trained settings was not significantly affected by the training of the noise suppression strength, and was moderately but not significantly correlated with the hours of aid use during the training period. Therefore, the customization of compression parameters that is currently performed in the clinic can at least partly be performed in real life listening situations by clients who have been fitted with this trainable aid.
Detection Efficiency of a Water-Based TSI Condensation Particle Counter 3785 (2006)

In this article we present observations on the detection efficiency of a recently developed TSI 3785 Water Condensation Particle Counter (WCPC). The instrument relies on activation of sampled particles by water condensation. The supersaturation is generated by directing a saturated airflow into a "growth tube," in which the mass transfer of water vapor is faster than heat transfer. This results in supersaturated conditions with respect to water vapor in the centerline of a "growth tube." In this study, the cut-off diameter, that is, the size, where 50% of the sampled particles are successfully activated, varied from 4 to 14 nm for silver particles as a function of temperature difference between the saturator and the growth tube. The solubility of the sampled particles to water played an important role in the detection efficiency. Cut-off diameters for ammonium sulphate and sodium chloride particles were 5.1 and 3.6–3.8 nm, respectively at nominal operation conditions. Corresponding cut-off diameter for hydrophobic silver particles was 5.8 nm.
Possible factors of leaf-feeding resistance in corn to the southwestern corn borer (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPossible factors of leaf-feeding resistance in corn to the southwestern corn borerPaul A. Hedin, Frank M. Davis, Willian P. Williams, and Marvin L. SalinCite this: J. Agric. Food Chem. 1984, 32, 2, 262–267Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/jf00122a022https://doi.org/10.1021/jf00122a022research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Theatre Censorship under the Royal Prerogative (2007)

Abstract This chapter explores the early history of theatre censorship exercised under the Royal Prerogative. Beginning with the Elizabethan period and concluding in the early 18th century, it gives a concise overview of the often arbitrary and inconsistent ways in which censorship (both pre-censorship and censorship after the event) was applied prior to the Licensing Act of 1737. Initially the censorship and licensing of plays was exercised by the Master of the Revels, for whom it was an immediate source of earned income. As from the Restoration period, the Lord Chamberlain became increasingly involved in the censorship of plays and the silencing of players or theatre managers.
An in Vivo Assay for Anti-LH-RH and Anti-FSH-RH Activity of Inhibitory Analogues of LH-RH<sup>∗</sup> (1975)

A convenient and sensitive method for testing anti-LH- and FSH-releasing activities of antagonists of LH-RH was devised. The peptides to be tested were injected subcutaneously together with synthetic LH-releasing hormone (LH-RH) in immature male rats. Serum LH and FSH concentrations were measured 30 min later by radioimmunoassay. In this system, [DesHis2]-LH-RH failed to block the pituitary response to LH-RH in agreement with previous data. The administration of [DesHis2, desGly10]-LH-RH ethylamide, [Des-His2, Leu3, des Gly10]-LH-RH ethylamide, [Des-His2, D-Ala6, des-Gly10]-LH-RH ethylamide, and [DESHis2, D-Ala6]-LH-RH in doses of 200 mug/rat, and [DesHis2, Leu3, D-Ala, desGly10]-LH-RH ethylamide in doses ranging from 100-400 mug/rat caused a significant inhibition of LH-RH-induced release of LH and FSH. On the other hand, [DesHis2, desGly10]-LH-RH propylamide, and [Leu2, Leu3, D-Ala6, desGly10]-LH-RH ethylamide failed to block the response to LH-RH. Among the peptides tested, [DesHis2, d-ala6, desGly10]-LH-RH etylamide, [Leu2, Leu3, D-Ala, desGly10]-LH-RH ethylamide in doses of 200 mug and [DesHis2, Leu3, D-Ala6, desGly10]-LH-RH ethylamide in a dose of 400 mug/rat showed some intrinsic LH and FSH-releasing activities. The method described here is simple and convenient for studying the anti-LH-RH release activity of inhibitory analogues of LH-RH, and also enabled us to demonstrate for the first time an in vivo inhibition of FSH release by these analogues.
Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere Division (2001)

Tumorigenic pituitary tumor transforming gene (PTTG) is a mammalian homolog of Xenopus securin that inhibits chromatid separation, is overexpressed in many human tumor types, and mediates transcriptional activation. Loss of yeast securin Pds1p or Drosophila securin pimples is lethal. Here we show that mice lacking PTTG (PTTG -/-) are, surprisingly, viable and fertile; but they have testicular and splenic hypoplasia, thymic hyperplasia, and thrombocytopenia. PTTG -/- mouse embryo fibroblasts exhibited aberrant cell cycle progression with prolonged G2-M phase and binucleated and multinucleated nuclei with increased aneuploidy. PTTG -/- mouse embryo fibroblast metaphases contained quadriradial, triradial, and chromosome breaks, as well as premature centromere division. The results show that PTTG functions to maintain chromosome stability, cell cycle progression, and appropriate cell division. Moreover, mammalian sister chromatid separation, an important transition in the cell cycle, is likely regulated by mechanisms in addition to securin.
B‐cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of <i>Bupleurum falcatum</i> L. and its structural requirement (1999)

Pectic polysaccharide fraction (BR-2) containing pharmacologically active pectic polysaccharide, bupleuran 2IIc, which was prepared from a medicinal herb, the roots of Bupleurum falcatum L., was administered orally to C3H/HeJ mice for 7 consecutive days. Proliferative responses of spleen cells were enhanced in the presence of the purified pectic polysaccharide, bupleuran 2IIc, but another B-cell mitogen, lipopolysaccharide (LPS) did not give a similar effect. In vitro studies using spleen cells showed that bupleuran 2IIc also stimulated lymphocytes, depleted of adherent cells or T cells. Bupleuran 2IIc treatment increased subpopulation of CD25+ and surface immunoglobulin M-positive (sIgM+) lymphocytes. Non-specific immunoglobulin secretion of spleen cells treated with bupleuran 2IIc was increased according to the culture time, and coexistence of interleukin-6 (IL-6) enhanced the secretion more than that of bupleuran 2IIc alone. These results suggest that bupleuran 2IIc proliferates B cells in the absence of macrophages, and the resulting activated B cells are then induced into antibody-forming cells in the presence of IL-6. Among the structural region of bupleuran 2IIc, ramified region (PG-1), which consists of rhamnogalacturonan core rich in neutral sugar chain, showed the potent mitogenic activity suggesting it to be an active site. Mitogenic activity of bupleuran 2IIc was reduced in the presence of antipolysaccharide antibody (antibupleuran 2IIc/PG-1-IgG), which recognizes the ramified region of bupleuran 2IIc as the antigenic epitope. Mitogenic activity of bupleuran 2IIc was also reduced by the addition of beta-d-GlcpA-(1-->6)-beta-d-Galp-(1-->6)-d-Galp or beta-d-GlcpA-(1-->6)-d-Galp, which are a part of the epitopes of antibupleuran 2IIc/PG-1-IgG. These results suggest that the epitopes in bupleuran 2IIc act as active sites of the polysaccharide during mitogenic activity.
A narrowband/wideband packet radio system (2002)

By transmitting packet headers on a narrowband channel, followed by packet data on a wideband channel, one can gain several advantages over using either narrowband or wideband techniques exclusively. All network nodes can easily obtain channel traffic loading and destination information by examining only the narrowband headers. Wideband synchronization is facilitated by using the end of the header transmission as a time index for wideband signal acquisition. Long signature sequences minimize the probability that two or more wideband packets will be transmitted with their sequences aligned, while avoiding the requirement that each receiver search for several different sequences as in a transmitter-oriented protocol. A common signature sequence facilitates packet broadcasting. Finally, flow control can be implemented by monitoring the CSMA narrowband channel and insuring that the network offered rate remains below the saturation point.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>