gebhart/patrepeval huggingface dataset:
Synthesis of Primaquine and Certain of its Analogs<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Primaquine and Certain of its Analogs1Robert C. Elderfield, Holly E. Mertel, Richard T. Mitch, Iris M. Wempen, and Eleanor WerbleCite this: J. Am. Chem. Soc. 1955, 77, 18, 4816–4819Publication Date (Print):September 1, 1955Publication History Published online1 May 2002Published inissue 1 September 1955https://pubs.acs.org/doi/10.1021/ja01623a038https://doi.org/10.1021/ja01623a038research-articleACS PublicationsRequest reuse permissionsArticle Views1377Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
COMPARISON OF TACROLIMUS WITH MICROEMULSION CYCLOSPORINE AS PRIMARY IMMUNOSUPPRESSION IN HEPATITIS C PATIENTS AFTER LIVER TRANSPLANTATION (1998)

(a) Both immunosuppression regimens had similar HCV recurrence rates; (b) there were no differences in bacterial or opportunistic infections; and (c) patient and graft survival was similar between the two groups.
ChemInform Abstract: CONDENSED 1,3,5‐TRIAZEPINES. III. DERIVATIVES OF 4,5‐DIHYDRO‐(1,3,5)TRIAZEPINO(1,2‐A)BENZIMIDAZOLE (1976)

Abstract Aus den Aminoalkoholen (I) werden über die Stufen (II) die Heterocyclen (IV) synthetisiert.
[Comparison of membrane current of vascular smooth muscle cells in brain artery of spontaneously hypertensive rats and Wistar rats]. (2013)

These results suggest that the current densities of VSMCs in BA of SHR and Wistar rats are significant different, the outward current of VSMCs in BA of SHR and Wistar rats are composed by Kv and BK(Ca). SHR express more STOCs mediated by BK(Ca), than Wistar rats.
Star-Shaped Oligotriarylamines with Planarized Triphenylamine Core: Solution-Processable, High-<i>T</i><sub>g</sub> Hole-Injecting and Hole-Transporting Materials for Organic Light-Emitting Devices (2010)

Two novel star-shaped oligotriarylamines with planar triphenylamine core and peripheral triarylamine groups, namely FATPA-T and FATPA-Cz, were synthesized by Suzuki cross-coupling reaction. The molecular design imparts the materials with the following features: (i) excellent thermal stabilities with quite high glass transition temperatures (237 °C for FATPA-T and 272 °C for FATPA-Cz); (ii) good solution-processability; (iii) good hole mobility, efficient hole injection, and electron-blocking functions. Furthermore, their optoelectronic properties can be modulated by the peripheral triarylamine groups. For example, FATPA-T with triphenylamine peripheries shows the significantly red-shifted absorption and emission, as well as the small band gap as compared to FATPA-Cz with carbazole peripheries. Double-layer Alq3-emitting OLEDs using FATPA-T or FATPA-Cz as hole-transport layer by spin-coating method were fabricated, and the FATPA-Cz-based devices show greatly improved performance as compared to standard NPB-based device by vacuum-evaporation of NPB. The optimized three-layer Alq3-emitting OLEDs by using FATPA-Cz and NPB as double hole-transport layers exhibit the maximum current efficiency of 6.83 cd/A, which is the highest for the Alq3-based green emission under the similar device structures. The advantages of solution-processablity and very high Tg make the star-shaped oligotriarylamines ideal substitutes for conventional arylamines as hole-inject and hole-transport materials.
Controlled Click‐Assembly of Well‐Defined Hetero‐Bifunctional Cubic Silsesquioxanes and Their Application in Targeted Bioimaging (2013)

A general procedure for the assembly of hetero-bifunctional cubic silsesquioxanes with diverse functionality and a perfectly controlled distribution of functional groups on the inorganic framework has been developed. The method is based on a two-step sequence of mono- and hepta-functionalization through the ligand-accelerated copper(I)-catalyzed azide-alkyne cycloaddition of a readily available octaazido cubic silsesquioxane. The stoichiometry of the reactants and the law of binomial distribution essentially determine the selectivity of the key monofunctionalization reaction when a copper catalyst with strong donor ligands is used. The methodology has been applied to the preparation of a set of bifunctional nano-building-blocks with orthogonal reactivity for the controlled assembly of precisely defined hybrid nanomaterials and a fluorescent multivalent probe for application in targeted cell-imaging. The inorganic cage provides an improved photostability to the covalently attached dye as well as a convenient framework for the 3D multivalent display of the pendant epitopes. Thus, fluorescent bioprobes based on well-defined cubic silsesquioxanes offer interesting advantages over more conventional fully organic analogues and ill-defined hybrid nanoparticles and promise to become powerful tools for the study of cell biology and for biomedical applications.
Cuffless Differential Blood Pressure Estimation Using Smart Phones (2012)

Smart phones today have become increasingly popular with the general public for their diverse functionalities such as navigation, social networking, and multimedia facilities. These phones are equipped with high-end processors, high-resolution cameras, and built-in sensors such as accelerometer, orientation-sensor, and light-sensor. According to comScore survey, 26.2% of U.S. adults use smart phones in their daily lives. Motivated by this statistic and the diverse capability of smart phones, we focus on utilizing them for biomedical applications. We present a new application of the smart phone with its built-in camera and microphone replacing the traditional stethoscope and cuff-based measurement technique, to quantify vital signs such as heart rate and blood pressure. We propose two differential blood pressure estimating techniques using the heartbeat and pulse data. The first method uses two smart phones whereas the second method replaces one of the phones with a customized external microphone. We estimate the systolic and diastolic pressure in the two techniques by computing the pulse pressure and the stroke volume from the data recorded. By comparing the estimated blood pressure values with those measured using a commercial blood pressure meter, we obtained encouraging results of 95-100% accuracy.
Robot planning in the space of feasible actions: two examples (2002)

Several researchers in robotics and artificial intelligence have found that the commonly used method of planning in a state (configuration) space is intractable in certain domains. This may be because the C-space has very high dimensionality, the "C-space obstacles" are too difficult to compute, or because a mapping between desired states and actions is not straightforward. Instead of using an inverse model that relates a desired state to an action to be executed by a robot, we have used a methodology that selects between the feasible actions that a robot might execute, in effect, circumventing many of the problems faced by configuration space planners. In this paper we discuss the implications of such a method and present two examples of working systems that employ this methodology. One system drives an autonomous cross-country vehicle while the other controls a robotic excavator performing a trenching operation.
Improved method for survivable network design based on pre-cross-connected trails (2007)

Previous work developed the concept of 'pre-cross-connected trails' (PXTs), which are fully pre-connected linear structures of spare capacity used to protect one or more paths end-to-end. To date, the only approach for designing PXT-based restorable networks is a heuristic algorithm suited for the dynamic protection of demands as they arrive in a network. The heuristic can also be used as a 'green fields' planning algorithm for a known set of demands by running through the set and protecting them in order. In both cases, however, recent work has shown that the resulting PXT structures can be looping, as well as long and complex. While the capacity efficiency of the designs was high, the practicality of using such convoluted structures in any real network is doubtful. In this work we propose a semi-heuristic approach based on integer linear programming methods that allows important properties of the PXTs (such as length and degree of looping) to be tightly controlled. We also show how this method may be adapted to the dynamic protection of incrementally arriving random demands. Results show that even when PXTs are restricted to be totally non-looping and of much lower maximum length, we still attain capacity efficiencies near those of the original PXT design heuristic. A notable extra finding is that, in an efficient PXT network design in general, many PXTs are equivalent to standalone 1+1 APS arrangements for certain demand flows.
Bio-Based Resins Begin to Grow (2008)

This article discusses the current use and future potential of soybean oil and corn ethanol in resins for composites manufacturing. Advances in biotechnology and genetic engineering are helping materials suppliers create soy- and corn-based derivatives that are increasingly viable replacements for petrochemicals in unsaturated polyester, polyurethane and epoxy resin formulations. Concerns about biodegradability, sustainability and the depletion of oil reserves have driven the commercial development of viable bio-based resins. Facilities and equipment already in place to produce soybean oil, corn oil and other derivatives for food and animal use provide a ready source of feedstock for new materials development. However, the growth of biofuels and bio-based resins has caused corn and soybean prices to steadily increase in the last year. Ford Motor Co. has been among the most active of the automakers that are exploring use of bio-based resins and fibers. The 2003 Model U concept car featured a glass fiber-reinforced, soy-based resin in the tailgate. Since then, Ford has been active researching bio-resins and compatibility with a variety of fillers and reinforcements. Although the bio-composites market is still in the very early stages of growth and development, the market forces that have spurred the most recent surge in bio-resin development inevitably will increase the use of renewable, sustainable plant products for composite resins.
Downy Mildew Resistance of the Cucumber Germplasm Collection in North Carolina Field Tests (1997)

Downy mildew [ Pseudoperonospora cubensis (Berk. & Curt.) Rostov] is an important disease in most cucumber ( Cucumis sativus L.) production areas of the world. Resistant cullivars are available, but higher levels of resistance are needed if yield losses are to be avoided. The objective of this experiment was to evaluate all available plant introduction accessions (from the U.S. National Plant Germplasm System), cultivars, and breeding lines (hereafter collectively referred to as cultigens) of cucumber for downy mildew resistance under field conditions in North Carolina. All available cultigens were tested in four blocks (2 yr and two replications) under natural field epidemics of the disease. Mean ratings for downy mildew leaf damage ranged from 1.3 to 9.0 on a 0 to 9 scale. The most resistant nine cultigens originated from the USA, and were primarily adapted cultivars or breeding lines. The most resistant cultigens, for which multiple‐year data were available, were Gy 4, ‘Clinton’, PI 234517, ‘Poinsett 76’, Gy 5, ‘Addis’, M 21, M 27, and ‘Galaxy’. The most susceptible cultigens for which multiple year data were available, were P1288995, P1176952, PI 178886, and P1211985. We classified 17 cultigens as highly resistant (1.3–3.0), 87 as moderately resistant (3.3–5.0), 311 as moderately susceptible (5.3–7.0), and 248 as highly susceptible (7.3–9.0) for the cultigens with multiple‐year data. No plant introduction accessions were found to be more resistant than the most resistant elite cultivars and breeding lines tested.
Acoustical holography based on Bojarski's exact inverse scattering theory (1987)

This paper investigated the use of Bojarski's exact inverse scattering theory (BEIST) as the basis of acoustical holography (AH). The purpose is to improve generalized holography although generalized holography originates from BEIST. Generalized holography is not the complete solution of BEIST and some information is missing. Generalized holography (GH) has to be recast as an inverse scattering problem and not as an inverse source problem. By interpreting GH as inverse scattering, one takes account of sound diffraction and refraction within an inhomogeneous object, giving detailed information on the object that is not available in GH. In the present AH setup, more than one scattering experiment has to be performed using different insonifying waves of different frequencies to determine the object's properties. This is the same as what is done in diffraction tomography experiment. The holographic field equation was obtained using the BEIST. It included the scattering amplitude. A set of simultaneous equations was obtained relating the object (or scatterer) to the recorded scattering amplitudes as specified for some discrete sets of frequencies. These simultaneous equations were solved for the scatterer in terms of the measured scattering amplitudes. A new type of exact inverse scattering algorithm for AH is proposed.
Synthetic Use Of Epoxy-Sugar Nucleosides (2007)

Preparation of 1',2 '-, 3 ',4 '-, and 4 ',5 '-epoxy derivatives of nucleosides and their use for the stereoselective synthesis of 1'- and 4 '-branched analogues are described.
White blood cell deformability and plugging of skeletal muscle capillaries in hemorrhagic shock (1980)

The cause of maldistributed capillary perfusion in hemorrhagic shock was investigated in a combined in vivo and in vitro study. The cat tenuissimus muscle was observed by vital microscopy before and after withdrawal of 45% of the blood volume. The induced shock conditions reduced the number of perfused capillaries about 50%. Close examination of the scattered, nonperfused capillaries showed that they remained open and almost invariably contained one or several leukocytes. These cells were usually located at the bulgings of endothelial cell nuclei, and when occasionally dislodged, recirculation immediately occurred. Platelet or erythrocyte aggregates were not seen in the microvasculature in shock. To test whether the trapping of leukocytes reflected an impaired deformability of these cells in shock or was merely a pressure dependent phenomenon, deformability studies were performed on leukocytes in vitro. Central venous blood was drawn before and 2 h after bleeding and leukocytes were separated by sedimentation. The passage-time of single leukocytes through a glass capillary stenosis at constant driving pressures was used as an index of cell deformability. No qualitative changes in stiffness were found after shock. The distribution of cell passage-times indicated, however, that the stiffest portion of the leukocyte population was removed from the circulation in shock.
Fast adders using enhanced multiple-output domino logic (1997)

Using an enhanced multiple output domino logic (EMODL) implementation of a carry lookahead adder (CLA), sums of several consecutive bits can be built in one nFET tree with a single carry-in. Based on this result, a new sparse carry chain architecture is proposed for the CLA adder. We demonstrate the design approach using a 32-b adder, and show that only four carries are sufficient for generating all sums, with a consequent reduction in the number of stage delays. Using a 1.2-/spl mu/m CMOS technology, we verify our simulation procedures by fabrication and measurement of a 2.7 ns critical path.
Three-dimensional structure of single-shelled bluetongue virus (1992)

The three-dimensional structure of single-shelled bluetongue virus has been determined to a resolution of 3 nm by using electron cryomicroscopy and image-processing techniques. The single-shelled virion has a diameter of 69 nm. The three-dimensional structure of the virion has icosahedral symmetry with a triangulation number of 13 in a left-handed configuration. The three-dimensional structure can be described in terms of two concentric layers of density surrounding a central core density. Two distinctive features of the outer layer are the 260 knobby capsomeres located at all the local and strict threefold axes and the aqueous channels located at all the five- and six-coordinated positions. These protrusions extend outward from an inner radius of 28 nm. They are interconnected out to a radius of 30 nm by saddle-shaped densities across the local and strict twofold axes. The aqueous channels surrounded by these capsomeres are about 8 nm wide at the outer surface and 8 nm deep. Some of these channels extend inward, penetrating the inner layer. These channels may provide pathways for transporting the metabolites and mRNA during the transcriptase activity of the particles. The inner layer is a featureless smooth bed of density except for the indentations in register with the channels of the outer layer. We propose that the 260 capsomeres in the outer layer are made up of trimers of the major protein, VP7, and that the inner layer is composed of the second major protein, VP3. The density in the central portion of the structure at a radius of less than 21 nm is likely due to the minor proteins and the genomic RNA.
The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo (1999)

We have tested the binding specificities of the pleckstrin homology (PH) domains of protein kinase B (PKB) and GRP1 (general receptor for phosphoinositides-1), expressed as green fluorescent protein (GFP) fusion proteins [PH(PKB)GFP and PH(GRP1)GFP respectively] in HEK 293 cells and Swiss 3T3 cells, using confocal microscopy. Stimulation of HEK 293 cells with insulin caused a small, but sustained, increase in PtdIns(3,4,5)P(3) levels, detected using a radioligand displacement assay, which was mirrored by the translocation of PH(PKB)GFP and PH(GRP1)GFP from the cytosol to the plasma membrane of live, transfected cells. Similar results were obtained using Swiss 3T3 cells stimulated with platelet-derived growth factor (PDGF) and expressing either PH(PKB)GFP or PH(GRP1)GFP. Biochemical analyses confirmed the accumulation of both PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2) in response to PDGF, but only the latter was present at increased levels in Swiss 3T3 cells 30 min after an oxidative stress (1 mM H(2)O(2)). Concomitantly, only PH(PKB)GFP, and not PH(GRP1)GFP, was localized at plasma membranes after 30 min of treatment with H(2)O(2). The fusion proteins appear accurately to report the spatial and temporal distribution of PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2) in intact cells. These results establish the lipid selectivity of these PH domains in vivo, and further emphasize the overlapping, but distinct, second messenger roles of PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2).
A direct access to layered zirconium-phosphonate materials from dialkylphosphonates (1999)

International audience
European and North American populations should be screened for coeliac disease (2003)

Coeliac disease (CD) is an immune mediated enteropathy triggered by ingestion of gluten containing grains in genetically susceptible individuals.1 CD is associated with HLA alleles DQ2 and/or DQ8, and in the continued presence of gluten the disease is self perpetuating.1,2 To sustain the position that active screening in search of CD cases is a justified policy, we will review the WHO guidelines for disease mass screening recommendations to establish whether CD satisfies these criteria.3



1. Early detection of the disease could be difficult on a clinical basis.

2. The disease must be a common disorder causing significant morbidity in the general population.

3. The screening tests must be highly sensitive and specific for the target disease.

4. A treatment for the disease must be available.

5. If not recognised, the disease could result in severe complications difficult to manage.



CD can manifest with a previously unsuspected range of clinical presentations, including the typical malabsorption syndrome (chronic diarrhoea, weight loss, abdominal distension) and a spectrum of symptoms …
Cooper: Cooperative Perception for Connected Autonomous Vehicles based on 3D Point Clouds (2019)

Autonomous vehicles may make wrong decisions due to inaccurate detection and recognition. Therefore, an intelligent vehicle can combine its own data with that of other vehicles to enhance perceptive ability, and thus improve detection accuracy and driving safety. However, multi-vehicle cooperative perception requires the integration of real world scenes and the traffic of raw sensor data exchange far exceeds the bandwidth of existing vehicular networks. To the best our knowledge, we are the first to conduct a study on raw-data level cooperative perception for enhancing the detection ability of self-driving systems. In this work, relying on LiDAR 3D point clouds, we fuse the sensor data collected from different positions and angles of connected vehicles. A point cloud based 3D object detection method is proposed to work on a diversity of aligned point clouds. Experimental results on KITTI and our collected dataset show that the proposed system outperforms perception by extending sensing area, improving detection accuracy and promoting augmented results. Most importantly, we demonstrate it is possible to transmit point clouds data for cooperative perception via existing vehicular network technologies.
Hepatotoxicity Associated with Angiotensin-Converting Enzyme Inhibitors (1993)

Hepatotoxicity, usually cholestatic in nature, has been reported with captopril, enalapril, and lisinopril use. Apparent cross-reactivity has been reported twice. Potential mechanisms of injury include idiopathic hypersensitivity and modulation of eicosanoid metabolism by inhibition of kininase II and subsequent increased hepatic bradykinin activity. Mediation via altered eicosanoid metabolism provides a plausible explanation for cross-reactivity among ACE inhibitors. Hepatotoxicity resolves if ACE inhibitors are stopped but may progress to liver failure if treatment is continued.
[Studies on the general properties of a novel microwave plasma enhanced glow discharge source]. (1998)

This paper introduced a novel microwave plasma enhanced glow descharge source, the structure design and operation were decribed, and the mutual effects of the main characters, such as pressure, current, voltage, microwave power and sputtering rates were also investigated in details.