gebhart/patrepeval huggingface dataset:
Studies on alcaptonuria (1947)

Research Article| January 01 1947 Studies on alcaptonuria: 2. Investigations on a case of human alcaptonuria A. Neuberger; A. Neuberger 1The National Institute for Medical Research, London, N.W. 3, the Department of Chemical Pathology and the Medical Unit, University College Hospital Medical School, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar C. Rimington; C. Rimington 1The National Institute for Medical Research, London, N.W. 3, the Department of Chemical Pathology and the Medical Unit, University College Hospital Medical School, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar J. M. G. Wilson J. M. G. Wilson 1The National Institute for Medical Research, London, N.W. 3, the Department of Chemical Pathology and the Medical Unit, University College Hospital Medical School, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1947) 41 (3): 438–449. https://doi.org/10.1042/bj0410438 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A. Neuberger, C. Rimington, J. M. G. Wilson; Studies on alcaptonuria: 2. Investigations on a case of human alcaptonuria. Biochem J 1 January 1947; 41 (3): 438–449. doi: https://doi.org/10.1042/bj0410438 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1947 CAMBRIDGE UNIVERSITY PRESS1947 Article PDF first page preview Close Modal You do not currently have access to this content.
The trials of wafer-scale integration: Although major technical problems have been overcome since WSI was first tried in the 1960s, commercial companies can't yet make it fly (1984)

The advantages and problems of wafer-scale integration (WSI) are described. The advantages of semiconductor integrated circuits are high reliability, minimized interconnections, and decreased signal delay. The problems concern heat removal, signal quality, and the need for discretionary wiring. Finally, some recent approaches to WSI fabrication are discussed.
On-line collision avoidance for the Ranger telerobotic flight experiment (2002)

This paper describes an online approach to whole-arm collision avoidance for the NASA Ranger Telerobotic Flight Experiment. Using a geometric world model, minimum distances and nearest points between parts of the active dexterous 7-DOF manipulator and potential obstacles are computed by the Ranger obstacle detection software. Obstacle data is then used to compute virtual repulsive forces which perturb the operator-commanded manipulator Cartesian motions in order to avoid collisions. The virtual forces are computed at the tool-tip for end-effector position perturbation, at the wrist for end-effector orientation perturbation, and on the upper and lower arm links for arm angle perturbation. The paper also describes the software development environment, utilizing a 3D graphical simulation and providing a graphical user interface for display and operator command. Results of several test runs illustrating end-effector position and orientation perturbation, as well as arm angle perturbation, are presented.
Prevalence and Characteristics of Central Compared to Obstructive Sleep Apnea: Analyses from the Sleep Heart Health Study Cohort (2016)

This is the largest community-based study of the prevalence and characteristics of CSA to date and demonstrates a prevalence of CSA that is intermediate to those previously noted. Contrary to prior data from clinic based samples, individuals with heart failure were much more likely to have OSA than CSA.
Dynamic shared visual spaces (2007)

We present an experimental study of automatic camera control in the performance of collaborative remote repair tasks using video-mediated communication. Twelve pairs of participants, one "helper" and one "worker," completed a series of Lego puzzle tasks using both a static camera and an automatic camera system that was guided in part by tracking the worker's hand position. Results show substantial performance benefits for the automatic system, particularly for complex tasks. The implications of these results are discussed, along with some lessons for the use of motion tracking as a driver for camera control.
{Ce<sub>10</sub>Mn<sub>8</sub>}: Cerium Analogues of the Decavanadate Archetype (2012)

Abstract In the presence of structure‐directing isobutyrate (ib) ligands, Ce III and Mn II salts undergo a sequence of oxidation and condensation steps, which result in the intermittent formation of the neutral coordination cluster [Mn 10 O 2 (ib) 18 (Hib) 2 ], followed by Mn‐decorated {Ce 10 Mn 8 } clusters. Their common inorganic {Ce IV 10 Mn II 2 Mn III 6 O 18 } core features a cerium oxide substructure with a decavanadate‐type metal framework, which showcases that molecular cerium oxide structures indeed can adopt certain structural principles of classical polyoxometalates. In addition, we identified the exact composition and structure of the precursor “manganese isobutyrate”, which actually consists of [Mn 6 (ib) 12 (Hib) 6 ] macrocycles.
Development of a universal model for description of intelligent field devices through the life-cycle (2009)

Integration of field devices is currently performed using different device models which all have a different focus. These models are represented by a vast number of different device description formats. For effectiveness of the integration processes, a comprehensive device description model that catches all relevant information is required. Based on an analysis of important formats, a device description model has been designed that covers all relevant information that was formerly stored in those different formats. In this paper the requirements for such a model are discussed, and a universal model integrating existing definitions is described.
Physico-chemical and Serological Characterization of Five Rhabdoviruses Infecting Fish (1975)

Viruses isolated from fish with viral haemorrhagic septicaemia (VHS), infectious haematopoietic necrosis (IHN), spring viraemia of carp (SVC), swim-bladder inflammation (SBI) and pike fry disease (PFD) have been grown to high titre in fathead minnow cells. While our preparations of the IHN, SVC, SBI and PFD viruses showed typical rhabdovirus morphology with bullet-shaped particles and distinct surface projections, the VHS virus preparations had a less typical rhabdovirus morphology but were pleomorphic with a preponderance of flexuous rods. Using virus labelled with [-3H]-uridine, it was shown that each virus contained RNA which sedimented at 38 to 40 S and was hydrolysed by very low concentrations of ribonuclease. The viruses of SVC, PFD and SBI had a polypeptide composition similar to that of vesicular stomatitis virus, the prototype rhabdovirus, but the IHN and VHS viruses gave a pattern similar to that of rabies virus. In serum neutralization tests the SVC and SBI viruses were indistinguishable. VHS virus showed no serological relationship with the other four viruses but there was a low level of cross-reaction between the PFD, IHN and SVC-SBI viruses.
Strength testing machines for wearable walking assistant robots based on risk assessment of Robot Suit HAL (2012)

The safety of wearable walking assistant robots (W2ARs) is expected to be guaranteed as they are spreading. From our experience of the risk assessments on Robot Suit HAL, we assume that the mechanical angle stoppers and appropriate assembling are inherent safety measures for the W2ARs. These measures prevent the hazardous situations: excess assistance and collision with floor or wall. In this paper, we develop the testing machines to prove their strength. They have the weights imitating a leg or a whole body and simulate cyclic impulsive load during walking by exploiting free fall. We hope this paper helps to develop safer W2ARs and to establish safety standards of the W2ARs.
Real-Time Occlusion Handling for Dynamic Augmented Reality Using Geometric Sensing and Graphical Shading (2012)

The primary challenge in generating convincing augmented reality (AR) graphics is to project three-dimensional (3D) models onto a user’s view of the real world and create a temporal and spatial sustained illusion that the virtual and real objects coexist. Regardless of the spatial relationship between the real and virtual objects, traditional AR graphical engines break the illusion of coexistence by displaying the real world merely as a background and superimposing virtual objects on the foreground. This research proposes a robust depth-sensing and frame buffer algorithm for handling occlusion problems in ubiquitous AR applications. A high-accuracy time-of-flight (TOF) camera is used to capture the depth map of the real world in real time. The distance information is processed in parallel using the OpenGL shading language (GLSL) and render to texture (RTT) techniques. The final processing results are written to the graphics frame buffers, allowing accurate depth resolution and hidden surface removal in composite AR scenes. The designed algorithm is validated in several indoor and outdoor experiments using the scalable and modular augmented reality template (SMART) AR framework.
Effect of the geometrical parameters on the electric field of pixelated two-dimensional arrays of γ-ray spectrometers (2000)

We study the effect of the geometrical parameters of pixelated two-dimensional (2D) arrays of γ-ray spectrometers upon the distribution of the electric field lines, which are induced by the applied voltage. It is shown that the size and in particular the separation between anodes strongly affect the field uniformity. The electric field is calculated by three methods including: (i) a commercial software for 3D field analysis based on finite element method; (ii) a 3D finite difference approach; and (iii) the Moments method. The required boundary conditions and the calculation efficiency of each method are compared. Since the uniformity of the electric field strongly affects the spectral performance of pixelated 2D arrays of γ-ray spectrometers, the results presented here are important for the optimal design and modeling of such arrays.
A 60-kDa plant microtubule-associated protein promotes the growth and stabilization of neurotubules  <i>in vitro</i> (1997)

The search for microtubule-associated proteins (MAPs) in plants is relatively recent. In particular, the "classical MAPs," which stimulate the polymerization and stabilization of microtubules, have only been examined in heterogeneous fractions. As a first step in dissecting the role of individual MAPs, we have chromatographically purified a single 60-kDa protein from a carrot MAP fraction and analyzed its effects on tubulin assembly. MAP60 promoted the formation of long, morphologically regular brain microtubules in vitro, an effect inhibited by preincubation of the MAP with affinity-purified antibodies against this protein. MAP60 also increased the stability of microtubules to dilution and significantly enhanced cold stability to the normally cold-sensitive neurotubules. These in vitro properties are consistent with a role for MAP60 in regulating the turnover/assembly of dynamic plant microtubules in vivo.
<i>Mycobacterium marinum</i> Erp Is a Virulence Determinant Required for Cell Wall Integrity and Intracellular Survival (2006)

The Mycobacterium tuberculosis exported repetitive protein (Erp) is a virulence determinant required for growth in cultured macrophages and in vivo. To better understand the role of Erp in Mycobacterium pathogenesis, we generated a mutation in the erp homologue of Mycobacterium marinum, a close genetic relative of M. tuberculosis. erp-deficient M. marinum was growth attenuated in cultured macrophage monolayers and during chronic granulomatous infection of leopard frogs, suggesting that Erp function is similarly required for the virulence of both M. tuberculosis and M. marinum. To pinpoint the step in infection at which Erp is required, we utilized a zebrafish embryo infection model that allows M. marinum infections to be visualized in real-time, comparing the erp-deficient strain to a DeltaRD1 mutant whose stage of attenuation was previously characterized in zebrafish embryos. A detailed microscopic examination of infected embryos revealed that bacteria lacking Erp were compromised very early in infection, failing to grow and/or survive upon phagocytosis by host macrophages. In contrast, DeltaRD1 mutant bacteria grow normally in macrophages but fail to induce host macrophage aggregation and subsequent cell-to-cell spread. Consistent with these in vivo findings, erp-deficient but not RD1-deficient bacteria exhibited permeability defects in vitro, which may be responsible for their specific failure to survive in host macrophages.
Ring-opening polymerization of heterobicyclic compounds. (1989)

Ring-opening polymerizations of heterobicyclic compounds such as bicyclic acetals, bicyclic oxalactones, and bicyclic oxalactams often proceed stereospecifically, due to their rigid bulky structures having two or more asymmetric centers as well as due to the stereoelectronic effect of the heteroatoms. The polymers derived form these heterobicyclic compounds generally contain heterocycles in their main chains and are expected to exhibit desirable properties and/or specific functions. Recent progress in this field, particularly in the following three subjects is described in this review.1. Stereoregulation in cationic polymerization of bicyclic acetals in relation to structurally controlled synthesis of polysaccharides.2. Highly selective cyclooligomerization of bicyclic oxalactones to macrocyclic oligoesters having a chiral cavity.3. Ring-opening polymerizations of novel heterobicyclic compounds aimed at designing specialty polymers.
Iron Excretion in Thalassaemia Major After Administration of Chelating Agents (1962)

The excretion of iron in the urine has been studied before and during treatment with a new chelating agent for iron, desferrioxamine.
Diverse replication for single-machine Byzantine-fault tolerance (2008)

New single-machine environments are emerging from abundant computation available through multiple cores and secure virtualization. In this paper, we describe the research challenges and opportunities around diversified replication as a method to increase the Byzantine-fault tolerance (BFT) of single-machine servers to software attacks or errors. We then discuss the design space of BFT protocols enabled by these new environments. 1
Thin Film Polycrystalline Silicon Solar Cells (2006)

This chapter contains sections titled: Introduction Potential of Polysilicon Solar Cells Substrates for Polysilicon Cells Film Formation Solar Cell and Module Processing Polysilicon Solar Cell Technologies Conclusion References
Reduction of dinitrogen by a zirconium phosphine complex to form a side-on-bridging N2 ligand. Crystal structure of {[Pri2PCH2SiMe2)2N]ZrCl}2(.mu.-.eta.2:.eta.2-N2) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of dinitrogen by a zirconium phosphine complex to form a side-on-bridging N2 ligand. Crystal structure of {[Pri2PCH2SiMe2)2N]ZrCl}2(.mu.-.eta.2:.eta.2-N2)Michael D. Fryzuk, T. S. Haddad, and Steven J. RettigCite this: J. Am. Chem. Soc. 1990, 112, 22, 8185–8186Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ja00178a063https://doi.org/10.1021/ja00178a063research-articleACS PublicationsRequest reuse permissionsArticle Views689Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Toward a National Framework for the Secondary Use of Health Data: An American Medical Informatics Association White Paper (2006)

Secondary use of health data applies personal health information (PHI) for uses outside of direct health care delivery. It includes such activities as analysis, research, quality and safety measurement, public health, payment, provider certification or accreditation, marketing, and other business applications, including strictly commercial activities. Secondary use of health data can enhance health care experiences for individuals, expand knowledge about disease and appropriate treatments, strengthen understanding about effectiveness and efficiency of health care systems, support public health and security goals, and aid businesses in meeting customers' needs. Yet, complex ethical, political, technical, and social issues surround the secondary use of health data. While not new, these issues play increasingly critical and complex roles given current public and private sector activities not only expanding health data volume, but also improving access to data. Lack of coherent policies and standard "good practices" for secondary use of health data impedes efforts to strengthen the U.S. health care system. The nation requires a framework for the secondary use of health data with a robust infrastructure of policies, standards, and best practices. Such a framework can guide and facilitate widespread collection, storage, aggregation, linkage, and transmission of health data. The framework will provide appropriate protections for legitimate secondary use.
Polyphenol E Enhances the Antitumor Immune Response in Neuroblastoma by Inactivating Myeloid Suppressor Cells (2013)

These findings suggest that the neuroblastoma-promoting activity of MDSCs can be manipulated pharmacologically in vivo and that green tea catechins operate, at least in part, through this mechanism.
The Waveguide Structure Based on the Polymer SU8 on a SiO<sub>2</sub>/Si Substrate (2011)

The paper deals with considerations concerning planar waveguide structures, in which the polymer SU8 is used as the waveguide layer. The results of numerical calculations of the distribution of the field concerning structures of various thicknesses have been presented, and photos taken in the course of investigating the surface by means of a microscope of atomic forces. The results of calculations of sensitivity in relation to the refractive index of the cover layer at various thicknesses of the layer have been presented, too.
Magnetostrictive Fe-Si thin films for tunable SAW devices (1980)

RF sputtered films of Fe <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> Si <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</inf> , where <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x \approx .7</tex> , deposited on YZ-LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> , have been used for magnetically variable surface acoustic wave devices. A 1 micron thick film one cm long in the SAW propagation direction had a relative SAW velocity change of 0.02% at 63 MHz and 0.05% at 189 MHz for applied fields of less than 50 Oe after annealing at 200°C for 30 minutes. Magnetic properties (M-H loops and magnetostriction) of the films were measured and correlated with the SAW properties.
A study of reticle non-flatness induced image placement error contributions in EUV lithography (2010)

Image placement (IP) and overlay error specifications are serious concerns for lithography at each successive technology node. Some of the primary contributors to image placement error (IPE) in EUV lithography are reticle and chuck surface non-flatness and chucking flatness non- uniformity. Flatness compensation has been proposed as a method to relax flatness specification for EUV substrates. However, in order for flatness compensation to work effectively, the various components of IPE i.e., reticle flattening and as-chucked z-height variation needs to be estimated accurately. Flatness compensation models assume a completely flat, rigid chuck and conformal clamping of the reticle backside. In this paper we will describe experiments designed to verify the different assumptions that the flatness compensation models are based on. The experiments involve printing wafers using a set of reticles of different flatness specifications on the ASML EUV Alpha Demo Tool (ADT) in Albany, NY. We will discuss results from these experiments and use Finite Element Modeling to simulate reticle chucking to correlate these results to physical properties electrostatic chuck on the ADT.
Parameters Involved in the <i>In Vitro</i> Immunization of Tonsilar Lymphoctyes: Effects of rIL-2 and Muramyl Dipeptide (1990)

A method for the in vitro immunization of human tonsilar lymphocytes is described. This method allows for the sensitization of B-cells against various antigens under serum-free medium conditions. The medium is supplemented with defined concentrations of antigen, rIL-2 and muramyl dipeptide to boost the immune responses. This method may prove useful for the generation of antigen reactive B-cells for use in human monoclonal antibody production and the study of the effects of other lymphokines on the in vitro immune response.
The relationship between multi‐drug resistance and resistance to natural‐killer‐cell and lymphokine‐activated killer‐cell lysis in human leukemic cell lines (1992)

Results concerning a possible link between susceptibility to natural-cell-mediated immune cytolysis and the multi-drug resistance (MDR) phenotype are conflicting. We evaluated in human acute lymphocytic leukemia the relationship between acquired drug resistance and susceptibility to cytolysis mediated by endogenous, interferon-activated, and interleukin-2-activated natural cytotoxic cells. Eight human leukemia drug-resistant/sensitive cell line pairs were evaluated; drug-resistant sub-lines included those selected for primary resistance to adriamycin, etoposide, teniposide, vincristine, and vinblastine. A majority of P-glycoprotein-positive MDR sub-lines displayed slight but statistically significant resistance to endogenous and/or interferon-activated natural-killer(NK)-cell-mediated lysis, as compared with the drug-sensitive parental type. P-glycoprotein-negative sub-lines displayed variable NK susceptibility; within this group, the variants selected for primary etoposide resistance were more susceptible to NK cytolysis than parental cells. Results of cold-target-inhibition experiments suggest that altered NK susceptibility does not arise solely from modulation of NK target recognition and adherence structures. IL2-activated killer (LAK) cells lysed both drug-sensitive and drug-resistant lines. Two MDR lines selected for primary etoposide resistance displayed enhanced LAK susceptibility. In contrast, the 2 variants selected for resistance to adriamycin exhibited partial resistance to LAK-mediated killing, which could be overcome at high effector-to-target ratios. Our results support the development of interleukin-2/LAK immunotherapy for the treatment of leukemias with acquired drug resistance.