gebhart/patrepeval huggingface dataset:
The Ultracentrifuge: Problems and Prospects<sup>*</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Ultracentrifuge: Problems and Prospects*Howard K. SchachmanCite this: Biochemistry 1963, 2, 5, 887–905Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://doi.org/10.1021/bi00905a001Request reuse permissionsArticle Views157Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (9 MB) Get e-Alertsclose Get e-Alerts
Reassessment of the <i>in vitro</i> synergistic effect of fluconazole with the non‐steroidal anti‐inflammatory agent ibuprofen against <i>Candida albicans</i> (2005)

We reassessed the in vitro synergistic effect of fluconazole with the non-steroidal anti-inflammatory agent ibuprofen against the pathogenic yeast Candida albicans. No synergistic effect of fluconazole combined with ibuprofen was seen against fluconazole-susceptible strains, but a remarkable effect was seen against fluconazole-resistant strains (FIX index: 0.02-0.03). Furthermore, vigorous growth of the microorganism, the so-called 'Eagle effect', was observed at concentrations higher than the minimal inhibitory concentrations of ibuprofen and fluconazole. Our results suggest that the combination of ibuprofen and fluconazole should prove useful for treating infection caused by fluconazole-resistant C. albicans.
A high performance differential amplifier through the direct monolithic integration of InP HBTs and Si CMOS on silicon substrates (2009)

We present results on the direct monolithic integration of III-V devices and Si CMOS on a silicon substrate. InP HBTs (0.5 times 5 um <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> emitter) with ft and fmax > 200 GHz were grown directly in windows adjacent to CMOS transistors on silicon template wafers or SOLES (Silicon on Lattices Engineered Substrates). A BCB based multilayer interconnect process was used to interconnect the InP HBT and Si CMOS to create a differential amplifier demonstration circuit. The heterogeneously integrated differential amplifier serves as the building block for high speed, low power dissipation mixed signal circuits such as ADCs and DACs.
S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. (1998)

The S100 family of calcium binding proteins has been shown to be involved in a variety of physiological function, such as cell proliferation, extracellular signal transduction, intercellular adhesion, motility as well as cancer metastasis. The role played by a member of the S100 gene family, viz. S100A4 (also referred to as mtsl, 18A2/mtsl, pEL-98, p9Ka, metastasin) in the control of cell proliferation as well as in cancer invasion and metastasis has now been extensively studied in a number of laboratories. The protein encoded by S100A4 gene is now known to be capable of regulating cell cycle progression, modulating intercellular adhesion and invasive and metastatic properties of cancer cells. The S100A4 protein appears to be able to sequester and disable the p53 suppressor protein which controls G1-S transition of cells as well as the exit of cells from the S phase into mitosis G2-M transition is believed to involve the induction of stathmin (Op18) gene expression. The expression of this gene has been found to parallel that of S100A4, S100A4 also appears to take part in the homeostasis of growth, with apparent involvement also in growth factor signal transduction and apoptotic cell death. There is considerable evidence that S100A4 expression alters the adhesive properties of cells, possibly by remodelling the extracellular matrix and promoting a redeployment of adhesion-mediating macromolecules occurring in the extracellular matrix. Using transfection technology, it has been shown that over-expression of S100A4 enhances lung colonisation by cancer cells. The transfection and expression of antisense constructs, in contrast, inhibit metastatic localisation in the lung. S100 proteins levels in serum and in tumour tissue are increasingly being monitored and have been regarded as good indicators of the state of cancer progression. Valuable evidence has accumulated regarding the expression of S100A4 in human melanomas. In carcinoma of the breast, the level of expression of S100A4 has been found to be closely related to metastatic spread of the cancer to regional lymph nodes. The purpose of this review is to emphasise the need to focus sharply upon the mechanisms by which S100 proteins in general and S100A4 in particular subserve the wide variety of functions currently attributable to them.
A nondestructive, statistical method for determination of initiation efficiency: dipentaerythritol-aided synthesis of ternary ABC3 miktoarm stars using a combined “arm-first” and “core-first” approach (2013)

The preparation of miktoarm stars, based on poly(ethylene oxide) (PEO), poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) and either poly(propylene oxide) (PPO) or poly(ethyl glycidyl ether) (PEGE), is described. Hereby, partly protected dipentaerythritol (dipentaerythritoldiacetonide) is used as a bifunctional alcohol in a polymer-based Williamson ether synthesis to become the core of the star. Mesylated PEO is reacted first with excess dipentaerythritoldiketal. This ensures full modification of the PEO with one telechelic dipentaerythritol moiety. This telechelic PEO with one hydroxyl function is then converted to a diblock copolymer with the dipentaerythritol unit at the junction point between the blocks. To achieve this, two pathways have been developed: (a) by reaction with ready-prepared, mesylated PPO and (b) by ring-opening, anionic polymerization of ethyl glycidyl ether, leading to a narrow dispersed block copolymer. The advantages and disadvantages of both routes are discussed, though both provide perfect scaffolds for further polymer grafting. This is achieved by mild deprotection of both diblocks in order to yield 4 hydroxyl functions at the core of the future star. After attachment of an initiator, atom transfer radical polymerization (ATRP) is used to grow up to 4 arms of PDMAEMA from the center of each diblock copolymer. Thus, (PEO)–(PDMAEMA)k–(PPO) or (PEO)–(PDMAEMA)k–(PEGE) heteroarm stars are prepared by a combined “arm-first” and “core-first” method. The molecular characterization is accompanied by NMR, size exclusion chromatography (SEC), osmometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI ToF MS). The latter method even allows an estimation of the initiation site efficiency during ATRP. In turn, the final molecular formula of the stars can be derived. We illustrate that a decreased initiation site efficiency generates a specific footprint in the molecular weight distribution, which could be partly reproduced by MALDI ToF MS. By comparing the simulated spectra with the real ones, one can draw conclusions on the initiation site efficiency. The obtained initiation site efficiency is found to be comparable to the one obtained by the standard destructive method: determination of molecular weight of cleaved arms, which is tedious and polymer-consuming. Therefore, it is anticipated that both the synthetic procedures as well as the analytics can be easily adapted to other polymers.
FAST ALGORITHM FOR MINING ASSOCIATION RULE (2006)

One of the important problems in data mining is discovering association rules from databases of transactions where each transaction consists of a set of items. The most time consuming operation in this discovery process is the computation of the frequency of the occurrences of interesting subset of items (called candidates) in the database of transactions. Can one develop a method that may avoid or reduce candidate generation and test and utilize some novel data structures to reduce the cost in frequent pattern mining ? This is the motivation of my study. A fast algorithm has been proposed for solving this problem. Our algorithm use the "TreeMap" which is a structure in Java language. Also we present "Arraylist" technique that greatly reduces the need to traverse the database. Moreover we present experimental results which show our structure outperforms all existing available algorithms in all common data mining problems.
Adaptive resource allocation in composite fading environments (2002)

We obtain optimal resource allocation policies for a single user single-carrier system and a multiple-access multi-carrier-CDMA system when the transmitter adapts to the variations in the short-term mean (slow fade) in a combined slow and fast fading (composite fading) environment. For the single user system, we maximize the average throughput achieved by the user, while In the uplink MC-CDMA system, we maximize the sum of average rates of the users in the system. For each system, we find the optimal resource allocation policies for two scenarios. The first is when is system is designed for voice transmission, where the bit error rate (BER) of each user, averaged over the fast fade, is maintained at a desired value. The second is when the system is designed for data transmission, where the BER of each user is maintained below a desired value for a given percentage of time. We find that, for the single-user system, the solution for both the voice and data transmission cases is waterfilling, and that waterfilling is the asymptotically optimal solution to multi-user problems in both scenarios, i.e. is nearly optimal for a large number of users. We also find that, when dealing with a voice system, the solution is independent of the distributions of the slow and fast fades and similar to the solutions obtained for noncomposite fading environments (fast or slow fading).
A subnanosecond 8K-gate CMOS/SOS gate array (1984)

An 8370-gate CMOS/SOS gate array has been developed using a Si-gate CMOS/SOS process with two-level metallization. The gate lengths of the transistors are 1.8 and 1.9 /spl mu/m for the n-channel and p-channel, respectively. Subnanosecond typical gate delay times have been obtained. Typical delay times of inverter, two-input NAND, and two-input NOR gates are 0.67, 0.87, and 0.99 ns, respectively, under a typical loading condition (three fan outs and 2 mm first metal). It is shown that ECL speed with CMOS power can be achieved in a system by using the CMOS/SOS gate array. Advantages of the SOS device on speed performance are also discussed.
A 1x2 MIMO Multi-Band CMOS Transceiver with an Integrated Front-End in 90nm CMOS for 802.11a/g/n WLAN Applications (2008)

With the introduction of mobile laptop platforms into the wireless communication market, the usage of WiFi in everyday life has taken off exponentially. Further penetration into additional platforms and products, such as handheld devices and PDAs, requires a dramatic reduction in cost and smaller form factors of the wireless device. This can only be achieved by higher levels of component integration onto the Silicon radio chips.
A matrix-based approach to reconstruction of 3D objects from three orthographic views (2002)

Presents a matrix-based technique for reconstructing solids with quadric surfaces from three orthographic views. First, the relationship between a conic and its orthographic projections is developed using matrix theory. We then address the problem of finding the theoretical minimum number of views that are necessary for reconstructing an object with quadric surfaces. Next, we reconstruct the conic edges by finding their matrix representations in 3D space. This effectively constructs a model corresponding to the three views. Finally, volume information is searched within the wireframe model to form the final solids. The novelty of our algorithm is in the use of the matrix representation of conics to assist in the 3D reconstruction, which increases both the efficiency and the reliability of the proposed approach.
Treatment of Refractory Chronic Pruritus of Unknown Origin With Tofacitinib in Patients With Rheumatoid Arthritis (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Type B RCD with a simplified magnetic modulation/demodulation method (2009)

In this paper, a type of Type B RCD applying a simplified magnetic modulation/demodulation method is designed to detect residual currents of sinusoidal AC, pulsating DC and smooth DC to protect person against indirect/direct contact and fire hazards. A modulation method based on RL self-oscillation circuit is applied to modulate AC and DC residual current with square-wave pulse signal. A simplified demodulation method, involving a 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> -order LPF (Low Pass Filter) circuit, is designed to easily measure AC and DC residual current. Type B RCD presented in the paper fulfills the AC and DC residual current protections complying with IEC60947-2 Annex B and IEC60755. Furthermore, this Type B RCD characterizes a simple structure, small size and low cost.
Leaching Behaviour of the Herbicide Mefenacet in Soil Columns (2000)

The leaching behaviour of [aniline-]mefenacet in soil was investigated using glass columns (5 cm I.D. 30 cm. H) packed with two types of soils with different physicochemical properties. -Mefenacet (8.33 kBq) and mefenacet (in total, 1.05 mg/kg) were treated onto soil columns and rice plants (Oryza sativa L.) were grown for 17 weeks on these columns. Leachates from the columns were collected at the rate of 122.5 mL per week. -Activities leached from soil A (OM, 3.1%; CEC, 86 mmol(+)/kg; texture, loam) columns with and without rice plants were 1.95 and 4.19% of the originally applied, whereas those from soil B (OM, 1.3%; CEC, 71 mmol(+)/kg; texture, loam) were 2.69 and 7.05%, respectively. These results indicated that larger amounts of were percolated from soil B with less organic matter and from the columns without vegetation. -Activities absorbed by rice plants from soil A and B were 8.95 and 8.47%, respectively, most of which remained in the root and shoot excluding unhulled grains and ears without grains. of the originally applied remained in the depth of in soil. The mass balance indicated that the losses by volatilization and/or mineralization amounted to of the originally applied. -Radioactivities in the aqueous phase of the leachates ranged from 59.4 to 97.7% of the radioactivities in leachates, showing the fast transformation of mefenacet to the polar metabolites.
Effects of low‐level hydrophobic substitution on conditioning properties of cationic cellulosic polymers in shampoo systems (2005)

A new class of cationic conditioning polymers (Polymer SL) has been prepared and evaluated in shampoo formulations. Polymer SL is a family of high viscosity quaternized hydroxyethyl cellulose (HEC) polymers with cationic substitution of trimethyl ammonium and dimethyldodecyl ammonium (Figure 1). SL compositions benefit from hydrophobic character to deliver superior conditioning performance in hair care applications. At the same time, low levels of hydrophobes have been chosen to assure good compatibility with surfactant systems without the complications of associative thickening. The polymers have been evaluated in clear shampoo formulations and two-in-one silicone containing shampoos using objective lab methods and subjective panel evaluation on hair tresses. Commercial conditioning polymers: Polyquaternium-10 (PQ-10) (UCARE Polymer LR-30M) and Guar Hydroxypro-pyltrimethylammonium Chloride (Jaguar C-13S) were used as performance benchmarks. The new hydrophobically-modified cationic polymers demonstrated superior performance in all major categories of conditioning and showed improved silicone deposition from two-in-one systems. Moreover, they retained other good qualities of their PQ-10 structural analogs such as enabling crystal clear formulations and showing no build-up or volume-down effects on hair. These new olymers were also found to be efficient conditioning agents in different surfactant systems with or without silicones.
Carbon Tetrachloride Injury of the Liver. The Protective Action of Certain Compounds. (1945)

SummarySeveral agents were tested for protective action against carbon tetrachloride injury of the liver in rats. Marked protection was obtained with sodium thioglycollate, appreciable protection with glutathione, moderate protection with sodium thiomalate, and slight protection with cystein—all sulphydryl compounds. Sodium glycollate and sodium malate afforded protection comparable to their sulphydryl homologues. Methionine, and choline plus cystine did not afford protection. Other non-sulphydryl compounds, i.e., sodium thiosulphate, aspartic acid, glutamic acid, choline, and sodium acetate afforded no protection.A protective action against carbon tetrachloride injury of the liver in rats is not as closely related to the presence of -SH in the test agent as previously was observed for the protective action of certain compounds against hepatic injury by chloroform in the dog.
Methods for robotic tool-mediated haptic surface recognition (2014)

Robots need to be able understand the haptic sensations that occur during physical interaction in order to recognize and manipulate objects. This paper centers on the problem of robotic toolmediated haptic surface recognition. We collected data as a PR2 robot interacted with fifteen different surfaces through a novel tool that captures high-definition recordings of tactile vibrations, contact forces, and tool position. We then developed algorithms for using the recorded data to recognize the identity of the surface under varying contact conditions. We show that successful recognition of surfaces touched through a tool critically depends on accounting for the physical contact information (tool speed and normal force). Additionally, we present several enhancements to improve surface recognition including the combination of multiple vibration axes into a single axis, using frictional force during contact, and logarithmically spaced frequency scaling for vibration analysis. We implement a flexible classifier composed of multiple One-Class Support VectorMachines trained on a data set containing all fifteen surfaces, and we then use this classifier to identify these same surfaces in a new data set recorded under substantially different contact conditions, achieving an overall texture recognition rate of 80%.
Utilizing Mobile Phones for Payment (2015)

This study introduces a sound-based mobile payment system. Using a mobile phone for payment for mobile commerce is essential for its success. The proposed system will use sound that is generated from the existing mobile phone and the sound can be recognized by the existing credit card reader of the shop with an installation of an ordinary microphone and simple software to process sound input. This system is a better system since it doesn't require customers to buy a new mobile phone and the cost for the microphone and the software is very low.
A Leptomycin B-sensitive Homologue of Human CRM1 Promotes Nuclear Export of Nuclear Export Sequence-containing Proteins inDrosophila Cells (2000)

The Rev protein of human immunodeficiency virus is a nuclear shuttling protein that promotes nuclear export of mRNAs that encode the viral structural proteins Gag, Pol, and Env. Rev binds to a highly structured RNA motif, the Rev-responsive element (RRE), that is present in all Rev-responsive viral transcripts and facilitates their entry into a nuclear export pathway by recruiting cellular export factors. In mammalian and yeast cells, the principal export receptor engaged by Rev has been identified as the importin/transportin family member CRM1/exportin 1. CRM1 binds directly to a leucine-rich nuclear export sequence (NES) present in Rev, and similar motifs have been identified in a variety of cellular nuclear shuttling proteins. We and our colleagues previously demonstrated that, in transfected Drosophila cells, HIV-1 Rev is fully functional and promotes expression of the viral envelope glycoprotein. We now demonstrate that the fundamental mechanism of Rev action in insect cells is identical to that observed in the mammalian systems. In particular, we show that Drosophila cells express a leptomycin B-sensitive homologue of human CRM1 that supports Rev-dependent gene expression and is required for nuclear export of NES-containing proteins in insect cells.
Discovery of Sulfated Sterols from Marine Invertebrates as a New Class of Marine Natural Antagonists of Farnesoid-X-Receptor (2011)

We report the biochemical characterization of sulfated polyhydroxysterols isolated from marine invertebrates as potent antagonists of farnesoid-X-receptor (FXR), a ligand-regulated transcription factor involved in the regulation of lipid and glucose homeostasis in mammals. Molecular characterization of a library of sulfated polyhydroxysteroids resulted in the identification of a first FXR antagonist. In contrast to partial antagonists, this compound was endowed with an antagonistic activity on the expression of a subset of FXR-regulated genes in liver cells and abrogated the release of nuclear coreceptor from the promoter of these genes. The putative binding mode to FXR, obtained through docking calculations, suggested the crucial role played by the bent shape of the molecule as well as the presence of one hydroxyl group in its side chain. This compound is a major tool to explore the effect of FXR inhibition in pharmacological settings.