gebhart/patrepeval huggingface dataset:
Pharmacological studies of the mechanism of tumor-induced bone marrow cytolysis. (1979)

The tumor-induced marrow cytotoxicity (TIMC) assay has been used in this study to explore in vitro the mechanism of cancer cell destruction of normal tissues. Previously, we have demonstrated that TIMC requires cell-cell contact. In this study, 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard, agents that alkylate DNA, RNA, and proteins, were effective inhibitors of TIMC. Since agents that inhibit tumor cell DNA, RNA, and protein synthesis (doxorubicin, cis -dichlorodiammineplatinum(II), methotrexate, 5-fluorouracil, actinomycin D, and emetine) were ineffective in inhibiting TIMC, we evaluated the possibility that previously synthesized cellular proteins are mediating TIMC. The microtubule inhibitors, vincristine and colchicine, and the microfilament inhibitor, cytochalasin B, were ineffective in inhibiting TIMC. The protease inhibitor N -α- p -tosyl-l-lysine chloromethyl ketone HCl, which has a trypsin specificity, was found to be an effective inhibitor of TIMC. l-1-Tosylamide-α-phenylethyl chloromethyl ketone, a protease inhibitor with chymotrypsin specificity, marginally inhibited cytotoxicity. Trasylol, a broad-spectrum protease inhibitor; p -tosyl-l-arginine methyl ester HCl, a competitive inhibitor of proteases and esterases; soybean trypsin inhibitor, a potent plasmin and protease inhibitor; and e-aminocaproic acid, a potent inhibitor of plasminogen activator did not inhibit TIMC. Dibutyryl cyclic adenosine 3′:5′-monophosphate enhanced TIMC at all doses tested. This is consistent with the observation in other studies that dibutyryl cyclic adenosine 3′:5′-monophosphate can increase both cell-bound and secreted enzyme activity. The necessity for intact cellular respiratory and energy-producing systems for TIMC was shown by the partial inhibition of TIMC by NaF and KCN. These data suggest to us that TIMC may be mediated by cellular proteins with serine protease activity.
Photoaffinity labeling of components of the apamin-sensitive K+ channel in neuronal membranes. (1985)

An azidonitrophenylaminoacetyl mono[125I]iodoapamin derivative was prepared which showed specific binding to rat neuronal membranes. UV photolysis lead to the irreversible occupation of binding sites. Photo-labeling of intact primary cultured rat neurones followed by membrane solubilization, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and autoradiography revealed the covalent incorporation of radioactivity into 3 main components with Mr = 86,000, 30,000, and 23,000. Labeling was completely prevented by a competing excess of native apamin. Similar studies on purified synaptic membranes from the rat brain showed another labeling pattern with major bands corresponding to Mr = 86,000 and 59,000. Although the reasons for the partial discrepancy between cultured embryonic neurons and an adult brain membrane fraction are not yet clear, we conclude that these proteins are intimately associated with the apamin binding site and are probably components of a type of Ca2+-activated K+ channel.
Influence of Soil Moisture Stress and Abscisic Acid Pretreatment in Modifying SO2 Sensitivity in Poinsettia (1986)

Abstract Soil moisture stress (SMS) and abscisic acid (ABA) pretreatment had a marked effect in modifying SO 2 sensitivity in 2 cultivars of poinsettia (Euphorbia pulcherrima Willd. ex Klotzch.) ‘Ruff and Reddy’ and ‘Rudolph’. Plants grown in 10-cm plastic pots in the greenhouse and exposed to SMS by withholding water for 2.5 days prior to SO 2 fumigation in the growth chamber (4 hr at 3 μ1·liter −1 ) showed greatly reduced SO 2 injury; both cultivars were protected similarly. SMS treatment also greatly decreased stomatal conductance and transpiration rate of the leaves. ‘Ruff and Reddy’ plants pretreated with ABA (200 mg·liter −1 of the racemic mixture) 4 hr prior to SO 2 fumigation were injured less by SO 2 than ‘Rudolph’ and had correspondingly lower stomatal conductance and transpiration rate. ‘Rudolph’ plants pretreated with ABA did not show significantly less SO 2 injury, even though stomatal conductance and transpiration rate were lower than controls after ABA pretreatment. These findings demonstrate the importance of moisture stress preconditioning in modifying sensitivity of poinsettia plants to SO 2 and suggest a protective role for ABA in certain cultivars.
Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD (2011)

Although culture-independent techniques have shown that the lungs are not sterile, little is known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We used pyrosequencing of 16S amplicons to analyze the lung microbiome in two ways: first, using bronchoalveolar lavage (BAL) to sample the distal bronchi and air-spaces; and second, by examining multiple discrete tissue sites in the lungs of six subjects removed at the time of transplantation. We performed BAL on three never-smokers (NS) with normal spirometry, seven smokers with normal spirometry ("healthy smokers", HS), and four subjects with COPD (CS). Bacterial 16 s sequences were found in all subjects, without significant quantitative differences between groups. Both taxonomy-based and taxonomy-independent approaches disclosed heterogeneity in the bacterial communities between HS subjects that was similar to that seen in healthy NS and two mild COPD patients. The moderate and severe COPD patients had very limited community diversity, which was also noted in 28% of the healthy subjects. Both approaches revealed extensive membership overlap between the bacterial communities of the three study groups. No genera were common within a group but unique across groups. Our data suggests the existence of a core pulmonary bacterial microbiome that includes Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, and Porphyromonas. Most strikingly, there were significant micro-anatomic differences in bacterial communities within the same lung of subjects with advanced COPD. These studies are further demonstration of the pulmonary microbiome and highlight global and micro-anatomic changes in these bacterial communities in severe COPD patients.
Real‐time ultrasound‐guided spinal anesthesia using the <scp>SonixGPS</scp> ultrasound guidance system: a feasibility study (2014)

The SonixGPS® system simplifies real-time ultrasound-guided spinal anesthesia to a large extent, especially the out-of-plane approach. Nevertheless, it remains a complex multi-step procedure that requires time, specialized equipment, and a working knowledge of spinal sonoanatomy.
Organic Halides and Nanocone Plastic Structures Enhance the Energy Conversion Efficiency and Self-Cleaning Ability of Colloidal Quantum Dot Photovoltaic Devices (2017)

This paper presents solid-state ligand exchange of spin-coated colloidal lead sulfide quantum dot (PbS QD) films by methylammonium iodide (MAI) and integration of them in depleted heterojunction solar (DHS) devices having an antireflecting (AR) nanocone plastic structure. Time-resolved photoluminescence measurements determine a shorter lifetime of the charge carries on a semiconductor (TiO2) electron transfer layer for the MAI-passivated QD films as compared with those with long-chain aliphatic or short thiol ligands. Consequently, the DHS device yields improved power conversion efficiency (>125%) relative to oleic-acid-passivated PbS QD films. Using anodized aluminum oxide templates, an inverted nanocone polydimethylsiloxane structure was also prepared and utilized as an AR layer in the DHS device. The solar cells exhibit an energy conversion efficiency of 7.5% with enhanced water-repellant ability.
Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophilderived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus (2009)

Development and progression of acquired abdominal aortic aneurysms (AAAs) have been associated with different inflammatory mediators. The aim of the present study was to elucidate the topology and the potential mechanisms linking the leukotriene pathway to human AAAs. Human aneurysmal lesions were obtained from 24 patients undergoing surgery, and the intraluminal thrombus was separated from the vascular wall. Histological examination revealed major expression of the leukotriene-producing enzymes 5-lipoxygenase and LTA(4) hydrolase, as well as the two receptors for leukotriene B(4) (BLT1R and BLT2R), corresponding to neutrophils in the luminal part of the thrombus. In contrast, in the vascular wall, the leukotriene pathway mainly localized in macrophage-rich adventitial areas. Furthermore, conditioned media of the intraluminal thrombus contained significantly higher concentrations of leukotriene B(4) than that derived from the vascular wall, which were significantly correlated to other neutrophil-derived mediators, such as elastase/alpha(1)-antitrypsin complexes, myeloperoxidase, and MMP9/NGAL complexes. Finally, the neutrophil-chemotactic activity of the conditioned media from the intraluminal thrombus exhibited major inhibition by antagonists of the leukotriene B(4) receptors. Taken together, these results indicate neutrophil-derived leukotriene B(4) as a major neutrophil chemotactic factor released from the intraluminal thrombus of human AAAs and suggest that targeting BLT receptors may represent a potential medical therapeutic strategy in the prevention of AAA progression in humans.
Self-isolated and high performance complementary lateral DMOSFETs with surrounding-body regions (2002)

This paper reports on self-isolated complementary Lateral DMOSFETs (LDMOSFETs) with Surrounding-Body regions (SE regions). They are fully compatible with 3 V CMOS, lateral NPN and lateral PNP by using the sub-micron Bi-CDMOS process. The N-channel and P-channel DMOSFETs show breakdown voltages of 87 V and 73 V, and specific on-resistances of 0.124 /spl Omega//spl middot/ mm/sup 2/ and 0/spl middot/315 /spl Omega//spl middot/mm/sup 2/, respectively.
Investigations of Potential-Dependent Fluxes of Ionic Permeates in Gold Nanotubule Membranes Prepared via the Template Method (2001)

We have been exploring the transport properties of gold nanotubule membranes prepared by electrolessly plating Au within the pores of a microporous polycarbonate filter. We have previously shown that when a potential that is negative of the potential of zero charge (pzc) of the membrane is applied, these membranes are cation permselective, and at potentials positive of the pzc, these membranes are anion permselective. A potentiometric method was used to demonstrate this potential-dependent ion permselectivity. Transport experiments showing how the fluxes of anionic and cationic permeate species change as a function of potential applied to the membrane were not done. Such transport experiments would provide a better indication of the ability of these membranes to separate cations from anions in a potential-dependent membrane-based separation process. For this reason, we have conducted a series of fundamental investigations aimed at determining how the fluxes of cations and anions change as a function of potential applied to the Au nanotubule membranes. Fluxes of two cationic and two anionic permeate species were investigated in membranes containing nanotubules with two different inside diameters. The anionic permeates showed high fluxes at positive applied potentials and low fluxes at negative applied potentials. The opposite trend was observed for the cationic permeates.
Operation Plan Optimization Method for Heat Interchange in Energy Network (2016)

A method for the operation plan optimization of energy networks is reported on in this paper. The method optimizes the operation of heat source equipment and pump. Its main feature is to consider the loss of pressure in pipes. All equations are linearized and the optimization is calculated by using MILP. This method is applied to energy networks with two connected areas. Those areas have facilities with different efficiency and different demand properties. The results of optimization verified the energy saving effect, in comparison with discrete areas.
A Gamma/Neutron Discriminating, Cooled, Optically Stimulated Luminescence (COSL) Dosemeter (1993)

The cooled optically stimulated luminescence (COSL) of CaF2:Mn (grain sizes from 0.1 to 100 µm) powder embedded in a hydrogenous matrix is reported as a function of fast neutron dose. When all the CaF2:Mn grains are interrogated at once, the COSL plastic dosemeters have a minimum detectable limit of 10 mSv fast neutrons; the gamma component from the bare 252Cf exposure was determined with a separate dosemeter. A proton recoil based dosemeter is described that generates pulse height spectra, much like the scintillator of Hornyak, to provide information on both the neutron and gamma dose. The plastic dosemeters were first submitted to an optical bleaching procedure using a high intensity ultraviolet laser and then exposed to fast neutrons using an unmoderated 252Cf source. The previously used COSL process relied on thermal contact of the cooled dosemeter with a room temperature slab of metal to promote electrons from the shallow traps. In this case, however, the standard COSL cooling and light-stimulation process was used to phototransfer electrons from deep to shallow traps, but with the use of a CO2 laser to warm the individual CaF2:Mn grains selectively within the plastic matrix. Grains within the plastic dosemeter that received large localised energy deposition produced larger-than-average COSL response when warmed by the CO2 laser. The data presented here demonstrate the concept of a neutron discriminating dosemeter. Future work will concentrate on the refinement of the individual grain readout process until individual grains receiving a single neutron-induced recoil proton can be distinguished.
Overview of Flame Retardants Including Magnesium Hydroxide (1998)

There are many classes of compounds which are useful as flame retardants. Inorganic minerals, organo-phosphates, and halogenated compounds are all commonly used for their ability to inhibit combustion and smoke generation in plastics and other materials. In 1993, United States industries consumed 810 million pounds of flame retardant additives, and demand is projected to be over one billion pounds in 1998. While currently a small part of this large market, Magnesium Hydroxide is attracting attention because of its performance, price, low corrosiveness, and low toxicity. The current market for magnesium hydroxide in flame retardants is about ten million pounds per year, with the potential to surpass thirty million pounds per year in the near future.
Ultra-high Isolation Nonreciprocal Acoustic Filters (2019)

We report on the design and performance of a novel nonreciprocal acoustic filter (nrFIL) topology. This relies on the use of acoustic filters placed in switch-based angular-momentum-biased circuits and enabling orders-of-magnitude higher isolation levels than attained by previously reported nrFILs-prototypes. We show that by strategically adding modulated ad-hoc shunt filtering branches to a conventional nrFIL, it is possible to modify its dynamics, thus enabling orders-of-magnitude higher isolation within a large portion of its static passband. To prove the effectiveness of this approach, we first designed, simulated and built a conventional switch-based nrFIL based on three commercial 895 MHz acoustic filters placed in a star-circuit topology. Then, three ad-hoc time-modulated filtering branches were inserted between the central node of the built nrFIL and ground. All circuit branches relied on the same modulation frequency (38MHz) to work. We show how this modification allows to increase the isolation (>25dB) attained by the conventional nrFIL prototype without degrading the minimum insertion loss attained in the passband of each acoustic filter (IL~6.5dB with or without the additional branches). Fractional bandwidth (BW <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">%</sub> ), 1 dB-compression input power (P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> ) and IIP3 approaching 2.2%, 21.5 dBm and 41 dBm are reported.
Indoor/Outdoor Location of Cellular Handsets Based on Received Signal Strength (2005)

This paper demonstrates the feasibility of received signal strength (RSS) methods for locating wireless handset calls in a real cellular environment. An extensive measurement campaign conducted on the Georgia Institute of Technology campus indicates that RSS location techniques can locate handset calls within 100 m error distance to its ground truth up to 78% of the time and less than 300 m error distance up to 98% of the time for a network with a majority of indoor users. This is well above the safety requirements mandated by FCC in the USA. We also propose a received signal strength aggregate (RSSA) method for identifying and locating indoor handsets.
Peer Reviewed: Mining Genomes with MS (1996)

ADVERTISEMENT RETURN TO ISSUEPREVFeaturesNEXTPeer Reviewed: Mining Genomes with MS Searching protein and nucleotide databases with MS data allows accurate identification of amino acid sequences John R. Yates, III, Ashley L. McCormack, and Jimmy EngCite this: Anal. Chemi. 1996, 68, 17, 534A–540APublication Date (Web):May 24, 2011Publication History Published online24 May 2011Published inissue 1 September 1996https://pubs.acs.org/doi/10.1021/ac962050lhttps://doi.org/10.1021/ac962050lresearch-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Genomics Get e-Alerts
Isolation and characterization of a high molecular weight stable pink form of uteroferrin from uterine secretions and allantoic fluid of pigs. (1986)

A pink, high molecular weight form of uteroferrin (Uf) has been isolated from uterine secretions and allantoic fluid of pigs. This protein fraction (denoted FIII) which is relatively stable under physiological conditions of pH, ionic strength, and temperature has a molecular weight of about 80,000, a value approximately twice that of purple Uf (Mr approximately 35,000) isolated from a separate fraction (FIV) by gel filtration. The visible absorption spectrum, EPR signal, and acid phosphatase activity of Uf in FIII are almost identical to those of FIV Uf after the latter has been reduced by 2-mercaptoethanol. However, unlike reduced FIV Uf, the pink, high molecular form does not revert to purple, nor does it show loss of EPR signal and phosphatase activity in the presence of oxygen. In addition, it does not become purple at orthophosphate concentrations which inhibit Uf acid phosphatase activity. Polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate has shown that FIII consists of approximately equal amounts of Uf polypeptides (Mr = 35,000 and 37,000) and a group of three polypeptides (Mr = 40,000, 46,000, and 50,000) antigenically unrelated to Uf. The latter share a common epitope not found on Uf and are probably differentially processed forms of the same protein. FIII can be dissociated by pH conditions below 5.0, by exposure to antibodies raised against Uf or the associated polypeptides, and by sodium dodecyl sulfate at 100 degrees C. The polypeptides in FIII are not therefore linked by disulfide bonds. Treatment with dimethyl suberimidate, however, results in a cross-linked complex (Mr approximately 82,000) consisting of Uf and the associated polypeptides. It is concluded that this high Mr form of Uf is a heterodimer of fully activated Uf and a second polypeptide of unknown function.
Neuronal Nicotinic Acetylcholine Receptors and Epilepsy (2002)

The identification of a genetically transmissible form of epilepsy that is associated with a mutation in CHRNA4, the gene that encodes the alpha4 subunit of the high-affinity nicotinic acetylcholine receptor, was the first demonstration that an alteration in a ligand-gated ion channel can cause seizures. Since then, nine mutations have been found, and analysis of their physiologic properties has revealed that all of them enhance receptor function.
The risk of occult invasive breast cancer after excisional biopsy showing in-situ ductal carcinoma of comedo pattern. (1989)

Between Jan. 1, 1985 and Aug. 31, 1987, 62 in-situ ductal carcinomas with a predominantly comedo pattern were identified in 61 patients in British Columbia from excisional biopsy of a palpable or mammographically demonstrable lesion of a breast. The biopsies were intended to remove the lesion completely. Fifty-seven (92%) of the 61 patients required wide re-excision or total mastectomy, usually within a month of the initial biopsy. Occult invasive disease was demonstrated in 14 of the re-excision specimens (24.5%) and residual in-situ carcinoma was present in a further 24 (42.1%), giving an overall rate of residual disease of 66.6%. Axillary lymph nodes were sampled in 54 cases. Metastases were found in two cases (3.7%) and each was associated with occult infiltrating ductal carcinoma in the breast. This suggests that in-situ ductal carcinoma having a predominant comedo pattern may be more widespread and associated with a higher incidence of invasive ductal carcinoma than is generally believed.
Alkaline phosphatase in benign and malignant cells in the vaginal smear (1951)

A I'P1,YING C;omot.i'stcchnicluei to vaginal-smear preparations, it has been loutid that m a n y of the epithelial cells present contain alkaline phosphatase.I t was tlecitled, therefore, to investigate the activity of this enzyme in the benigri-and inalignant-cell types in tlic epithelial smear.In the approach to this study, it was considered that data on the enzyme characteristics of the cell niight be applied to further the information that the \.aginal smear affords in endocrine assay and c a i i ( ~r detection.Since there have been suggestions of a direct liormonal-enz~-me relationship between estrogen and alkaline phosphatase,'. 2 , : ~ 4 , 8 % 11 tlie possibility of obtaining further information on this relationship also appeared promising.No previous studies on alkaline phosphatasc in the huntan vaginal tract have been rcportcd.Its distribution in the endometrinm I;rom the C! tological Laboratories, Donner Building for .\2etlicalKesearth, JlcGill University, hlontreal, ( : a i l a h .'l'lie pi-cseiice of alkaline phosphatase in the \agiii;il ~;ine;ii-\ \ a s first tlctected b y the author in 1948 while working in association Xvitli Dr.I V .Einerccon,