gebhart/patrepeval huggingface dataset:
Silencing of NbNAP1 Encoding a Plastidic SufB-like Protein Affects Chloroplast Development in Nicotiana benthamiana (2005)

It was previously shown that AtNAP1 is a plastidic SufB protein involved in Fe-S cluster assembly in Arabidopsis. In this study, we investigated the effects of depleting SufB protein from plant cells using virus-induced gene silencing (VIGS). VIGS of NbNAP1 encoding a Nicotiana benthamiana homolog of AtNAP1 resulted in a leaf yellowing phenotype. NbNAP1 was expressed ubiquitously in plant tissues with the highest level in roots. A GFP fusion protein of the N-terminal region (M1-V103) of NbNAP1 was targeted to chloroplasts. Depletion of NbNAP1 resulted in reduced numbers of chloroplasts of reduced size. Mitochondria also seemed to be affected. Despite the reduced number and size of the chloroplasts in the NbNAP1 VIGS lines, the expression of many nuclear genes encoding chloroplast-targeted proteins and chlorophyll biosynthesis genes remained unchanged.
Compressed Data Aggregation: Energy-Efficient and High-Fidelity Data Collection (2013)

We focus on wireless sensor networks (WSNs) that perform data collection with the objective of obtaining the whole dataset at the sink (as opposed to a function of the dataset). In this case, energy-efficient data collection requires the use of data aggregation. Whereas many data aggregation schemes have been investigated, they either compromise the fidelity of the recovered data or require complicated in-network compressions. In this paper, we propose a novel data aggregation scheme that exploits compressed sensing (CS) to achieve both recovery fidelity and energy efficiency in WSNs with arbitrary topology. We make use of diffusion wavelets to find a sparse basis that characterizes the spatial (and temporal) correlations well on arbitrary WSNs, which enables straightforward CS-based data aggregation as well as high-fidelity data recovery at the sink. Based on this scheme, we investigate the minimum-energy compressed data aggregation problem. We first prove its NP-completeness, and then propose a mixed integer programming formulation along with a greedy heuristic to solve it. We evaluate our scheme by extensive simulations on both real datasets and synthetic datasets. We demonstrate that our compressed data aggregation scheme is capable of delivering data to the sink with high fidelity while achieving significant energy saving.
The Significance of TFPI in Clotting Assays – Gomparison and Combination with other Anticoagulants (1993)

The anticoagulant activities of Tissue Factor Pathway Inhibitor (TFPI), heparin and hirudin were compared in intrinsic (APTT) and extrinsic (PT) activated clotting assays. In contrast to the thrombin inhibitor hirudin, heparin was 10 fold more potent in the APTT assay than in the PT assay, indicating that inhibition of intrinsic activation is important for the anticoagulant activity of heparin as measured in an APTT assay. TFPI was most potent in the PT assay and the effect of TFPI was most pronounced in the presence of other anticoagulants (heparin and hirudin). The activities of the two natural anticoagulants antithrombin III (ATIII) and TFPI were compared in a PT assay with very dilute tissue factor. In this assay system TFPI in normal plasma affected the clotting time more than ATIII in the plasma. However, when heparin was added ATIII was the major anticoagulant, but profound prolongation of the clotting time was only seen when TFPI was also added. In an ATIII deficient plasma heparin did not augment the effect of TFPI, showing that the increased effect of TFPI in the presence of heparin is dependent on the anticoagulant activity of ATIII/heparin. The effect of TFPI at prolonged clotting times was also illustrated by the significant effect of blocking TFPI in the plasma from warfarin-treated patients. Thus TFPI is a major anticoagulant in normal plasma and the effect of TFPI is especially seen at prolonged clotting times.
Detecting Diseases by Human-Physiological-Parameter-Based Deep Learning (2019)

The application of artificial intelligence in auxiliary diagnosis diseases has become a current research hotspot. The traditional method of diagnosing diabetes circulatory complication, diabetic peripheral neuropathy hyperlipidemia, diabetes mellitus peripheral angiopathy, and the comprehensive diseases is to distinguish an inspection report by a professional doctor. Its implementation of the clinical decision support algorithm for medical text data faces a challenge with the confidence level and accuracy. We proposed an expanding learning system to detect diseases above in our medical text data, which cover many kinds of physiological parameters of human, such as hematologic parameters, urine parameters, and biochemical detection. First, the raw data were expanded and corrected. Second, the processed data were fed into a 1D-convolution neural network with dropout and pooling. Our algorithm achieves 80.43%, 80.85%, 91.49%, 82.61%, and 95.60% with testing datasets (46 subjects). The effect of data quantification on model performance also had been researched, and the different data quantification methods would affect model performance on distinguishing different diseases. The proposed auxiliary diagnostic systems that have a highly accurate and robust performance can be used for preliminary diagnosis and referral; therefore, it is not only saving many human resources but also resulting in improved clinical diagnostic efficiency.
Spiral trajectory design: A flexible numerical algorithm and base analytical equations (2013)

A versatile numerical algorithm was developed, and was written in publicly available code. Approximate analytical formulas are given that help characterize spiral trajectories.
A single-photon-counting Fourier transform microfluorometer (1986)

Describes a microfluorometer, for steady-state and time-resolved analyses, which combines variable-frequency modulation of a continuous light source with single-photon counting electronics. Modulation frequency is easily adjusted to facilitate measurement of a wide range of decay times. Data may be collected at high count rates, whilst maintaining a low probability of photon detection in a single cycle of the modulation. Information equivalent to phaseshift and demodulation ratio is obtained by fast Fourier transform (FFT) of sample and reference data sets. The transform ideally matches the form of data, simultaneously analyses all harmonics present in the modulation and also quantifies the effects of systematic errors.
[Study on the association of 3 SNPs of FcRL3 gene with Graves disease in Chongqing Han population]. (2009)

The results of multi-allele and haplotype analysis indicated that the polymorphisms of the promoter A/G,exon 2 C/G,exon 4 C/T in the FcRL3 gene were possible risk factors to GD in Chongqing Han population.
An analysis for the realization of an in-place and in-order prime factor algorithm (1993)

It is shown that the prime factor algorithm (PFA) has an intrinsic property that allows it to be easily realized in an in-place and in-order form. In contrast to other approaches that use two equations for loading data from and returning the results to the memory, respectively, it is shown formally that in many cases only one equation is enough for both operations. Thus a truly in-place and in-order computation is obtained. Nevertheless, the sequence length of the PFA computation must be carefully selected. The conditions under which a particular sequence length is possible for in-place and in-order PFA computation are analyzed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
HPMA Polymer-Based Site-Specific Delivery of Oligonucleotides to Hepatic Stellate Cells (2009)

The objective was to determine whether bioconjugation of type I collagen specific triplex forming oligonucleotide (TFO) to N-(2-hydroxypropyl) methacrylamide (HPMA) containing tetrapeptide Gly-Phe-Leu-Gly (GFLG) and mannose 6-phosphate (M6P) can provide their targeted delivery to hepatic stellate cells (HSCs). Following bioconjugation, M6P-GFLG-HPMA-GFLG-32P-TFO was characterized by PAGE, HPLC, and GPC, and then its biodistribution was determined. TFO was dissociated from the conjugate when incubated with papain and formed triplex with the target DNA duplex. Type 1 collagen gene expression was significantly inhibited when HSC-T6 cells were transfected with this conjugate. Following tail vein injection into rats, M6P-GFLG-HPMA-GFLG-(32)P-TFO was rapidly cleared from the circulation and accumulated mainly in the liver. The plasma concentration versus time profile was biphasic, with 12.37 min as t(1/2) of distribution and 2886.48 min as t(1/2) of elimination. A large proportion of the injected M6P-GFLG-HPMA-GFLG-32P-TFO was taken up by the HSCs of both normal and fibrotic rats, which were isolated by liver perfusion at 30 min post-injection. Preinjection of M6P-GFLG-HPMA-GFLG-ONP into fibrotic rats decreased the liver uptake of the conjugates from 60% to 13%, suggesting M6P/TGFII receptor-mediated endocytosis of the conjugates by HSCs. Almost 80% of the total liver uptake in fibrotic rats was contributed by HSCs. In conclusion, conjugation with M6P-HPMA-GFLG significantly increased TFO delivery to the HSCs and could be potentially used for treating liver fibrosis.
The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway (2009)

Rhizoma Paridis, a traditional Chinese medicine, has shown promise in cancer prevention and therapy. In the present study, we isolated Paris Saponin I (PSI), an active component of Rhizoma paridis, and evaluated its effects on a panel of human cell lines and in a mouse model of human ovarian cancer to explore the mechanisms of its activity. PSI had more potent and selective cytotoxic effects on tumor cell lines than etoposide had, promoting dramatic G(2)-M phase arrest and apoptosis in SKOV3 cells in a time- and dose-dependent manner. Furthermore, PSI treatment increased levels of Bax, cytochrome c, activated caspase-3, active caspase-9, and cleaved poly(ADP-ribose) polymerase and decreased both Bcl-2 expression levels and extracellular signal-regulated kinase-1/2 activity. We also assessed the antitumor efficacy of i.p. and p.o. PSI administration in mice bearing SKOV3 tumors; both significantly inhibited the growth of SKOV3 cells in a subcutaneous xenograft mouse model (by 66% and 52%, respectively). These results indicate that PSI mediates its effects via mitochondrial apoptosis, mitogen-activated protein kinase pathways, and G(2)-M cell cycle arrest. Most important, the efficacy of PSI in xenografts when administered p.o. or i.p. suggests its clinical potential. Thus, PSI is a potent antitumor compound and should be developed as a natural agent for cancer therapy.
Fibrin Sealants in Dura Sealing: A Systematic Literature Review (2016)

Fibrin sealants are widely used in neurosurgery to seal the suture line, provide watertight closure, and prevent cerebrospinal fluid leaks. The aim of this systematic review is to summarize the current efficacy and safety literature of fibrin sealants in dura sealing and the prevention/treatment of cerebrospinal fluid leaks.
Role of Chromosomal and Plasmid-Borne Receptor Homologues in the Response of <i>Bacillus megaterium</i> QM B1551 Spores to Germinants (2007)

Spores of Bacillus megaterium QM B1551 germinate in response to a number of trigger compounds, including glucose, proline, leucine, and inorganic salts. An approximate 6-kb region of the 165-kb plasmid was found to harbor a tricistronic receptor operon, gerU, and a monocistronic receptor component, gerVB. The gerU operon was observed to complement the germination response in plasmidless strain PV361 to glucose and leucine, with KBr acting as a cogerminant. Proline recognition is conferred by the monocistronic gerVB gene, the presence of which also improves the germination response to other single-trigger compounds. A chimeric receptor, GerU*, demonstrates interchangeability between receptor components and provides evidence that it is the B protein of the receptor that determines germinant specificity. Introduction of the gerU/gerVB gene cluster to B. megaterium KM extends the range of germinants recognized by this strain to include glucose, proline, and KBr in addition to alanine and leucine. A chromosomally encoded receptor, GerA, the B component of which is predicted to be truncated, was found to be functionally redundant. Similarly, the plasmid-borne antiporter gene, grmA, identified previously as being essential for germination in QM B1551, did not complement the germination defect in the plasmidless variant PV361. Wild-type spores carrying an insertion-deletion mutation in this cistron germinated normally; thus, the role of GrmA in spore germination needs to be reevaluated in this species.
CorNet: Siemens' contribution to the standardization of signaling in corporate ISDN networks (1988)

To make possible a complete integration of all telecommunication functions and to allow for the network-wide control of supplementary services, private networks are combined to form corporate ISDN networks. CorNet is the comprehensive protocol for signalling in such corporate ISDN networks. The authors explain the intentions of CorNet, clarify its relationship to other national or international ISDN protocol specifications and demonstrate some of the new features which were introduced with CorNet. CorNet is definitely committed to CCITT standards. It specifies how these standards apply for communication in corporate networks, and what additional extensions are required to satisfy the demands of private signalling. >
Software tools and support environment of the national centre for supervision and management of the Italian telephone network (1989)

The approach followed for the National Supervision Centre (CSN) is based on the principles of object-oriented software design and the finite state model, which allows the construction of systems by composing a set of modules both logically and physically disjointed. Each module can be referred at the same time as an object implementing a set of operations on its encapsulated data or as one of the concurrent communicating processes of the system. The methodology must be supported by a minimum set of procedures for process organisation and message passing. For this, the CCITT specification and description language was selected. After a brief description of the software quality aspects that must be taken into account, the architecture and most significant functionalities of the CSN system are described. Then the methodology is introduced together with examples of application to a real case.
Synthesis and pharmacological properties of soft drug derivatives related to perhexiline (1988)

In the hope of reducing the toxicity of perhexiline, a series of 27 cyclohexylaralkylamines II based on the "soft drug" concept and incorporating an amide function were synthesized. In a preliminary screening, compounds were evaluated for their alpha-adrenolytic activities. Several derivatives, especially N-(cyclohexylphenylmethyl)-2-(cyclohexyl-methylamino)acetamide (3), N-(cyclohexylphenylmethyl)-2-(homoveratrylmethylamino)acetam ide (7), and N-[2-(cyclohexylamino)ethyl]-alpha-cyclohexylbenzeneacetamide (23) had the same activity range as perhexiline in vitro in rat aorta strips. The in vitro metabolism of these three molecules was then investigated and compared to that of perhexiline. The effect upon the alpha-adrenolytic activity of introducing various N-aralkylamine groups on II was examined. Structure/activity relationships are discussed.
Retrospective evaluation of two latex agglutination tests for detection of circulating antigens during invasive candidosis (1992)

Two latex agglutination tests for the detection of Candida antigens, Pastorex Candida (Sanofi Diagnostics Pasteur, Marnes-la-Coquette, France) and Cand-Tec (Ramco Laboratories, Inc., Houston, Tex.), were applied to 79 serum samples from 19 patients who were retrospectively selected on the basis of mycological and clinical evidence of C. albicans infection and the availability of serial serum samples taken near the date of a positive culture. The specificity in 60 control individuals was 100% for Pastorex and 98.3% for Cand-Tec. The tests scored positive for 10 (52.6%) and 9 (47.4%) patients, respectively. Pastorex detected antigen in only 3 of 12 patients (25%) with positive antibody detection tests, but was positive for all 7 patients (100%) who produced no or a low antibody response, suggesting that the test performs better in the absence of antibodies. However, the sensitivity of Pastorex also increased with the number of samples available per patient, which was lower for high-antibody-responder patients (2.8 versus 5.7). If the patients who provided only one or two serum samples were eliminated, the sensitivity of Pastorex rose to 76.9%. For the Cand-Tec, the sensitivity was not related to the presence of antibodies, nor was it related to the number of samples per patient. The observed antigenemia was transient with both Pastorex and Cand-Tec. Only 12.5% of the positive reactions occurred on the same serum sample, confirming that the two tests react with different antigens. A positive antigen test preceded other diagnostic indications for 6 of 10 Pastorex-positive patients and 5 of 9 Cand-Tec-positive patients.
Penetration of a strong electromagnetic wave in an inhomogeneous plasma generated by ECR using a magnetic beach (1971)

This paper deals with the penetration of a strong electromagnetic wave into a dense inhomogeneous plasma generated by electron cyclotron absorption of this wave on a magnetic beach. It was experimentally found that the plasma density increases considerably after a certain time. This increase of plasma density is due to a passage of an electromagnetic wave through an evanescent region which appears in the inhomogeneous plasma in the region where the electron density is such that omega 02/ omega 2 approximately=1; omega is the frequency of the wave which generates and penetrates the plasma, omega 0 is the plasma frequency. The time dependences of the reflected power, spatial electron density distribution and transmitted power demonstrate the existence of the evanescent region and show the conditions for the free passage of the electromagnetic wave through this region. The experimental results are in a good qualitative agreement with the theory.
Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells (2004)

Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model. Here, we show that their expression is a generalized feature of nematode infection and that they are induced at the site of infection with both the tissue nematode Litomosoides sigmodontis and the gastrointestinal nematode Nippostrongylus brasiliensis. At the sites of infection with N. brasiliensis, we also observed induction of other chitinase and Fizz family members (ChaFFs): acidic mammalian chitinase (AMCase) and Fizz2. The high expression of both Ym1 and AMCase in the lungs of infected mice suggests that abundant chitinase production is an important feature of Th2 immune responses in the lung. In addition to expression of ChaFFs in the tissues, Ym1 and Fizz1 expression was observed in the lymph nodes. Expression both in vitro and in vivo was restricted to antigen-presenting cells, with the highest expression in B cells and macrophages. ChaFFs may therefore be important effector or wound-repair molecules at the site of nematode infection, with potential regulatory roles for Ym1 and Fizz1 in the draining lymph nodes.
Transmission of sound generated by sternal percussion (1989)

We indirectly determined the transmission path of sound generated by sternal percussion in five healthy subjects. We percussed the sternum of each subject while recording the output audio signal at the posterior left and right upper and lower lung zones. Sound measurements were done during apnea at functional residual capacity, total lung capacity, and residual volume both with the lungs filled with air and with an 80% He-20% O2 (heliox) gas mixture. Three acoustic indexes were calculated from the output sound pulse: the peak-to-peak amplitude, the peak frequency, and the mid-power frequency. We found that the average values of all indexes tended to be greater in the upper than in the ipsilateral lower lung zones. In the upper zones, peak-to-peak amplitude was greater at total lung capacity and residual volume than at functional residual capacity. Replacing air with heliox did not change these results. These experiments, together with others performed during Mueller and Valsalva maneuvers, suggest that resonance of the chest cage is the predominant factor determining the transmission of sternal percussion sounds to the posterior chest wall. The transmission seems to be only minimally affected by the acoustic characteristics of the lung parenchyma.
Hydrogenated carbon films produced by sputtering in argon–hydrogen mixtures (1982)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. R. McKenzie, R. C. McPhedran, L. C. Botten, N. Savvides, and R. P. Netterfield, "Hydrogenated carbon films produced by sputtering in argon–hydrogen mixtures," Appl. Opt. 21, 3615-3617 (1982) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Comparison of Phosphorus and Silicon:  Hypervalency, Stereochemistry, and Reactivity (1996)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of Phosphorus and Silicon: Hypervalency, Stereochemistry, and ReactivityRobert R. HolmesView Author Information Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003-4510 Cite this: Chem. Rev. 1996, 96, 3, 927–950Publication Date (Web):May 9, 1996Publication History Received19 March 1995Revised1 February 1996Published online9 May 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/cr950243nhttps://doi.org/10.1021/cr950243nresearch-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views3796Altmetric-Citations440LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Mathematical methods,Phosphorus,Silicon,X-rays Get e-Alerts