gebhart/patrepeval huggingface dataset:
Physiological Basis for Differential Sensitivities of Plant Species to Protoporphyrinogen Oxidase-Inhibiting Herbicides (1991)

With a leaf disc assay, 11 species were tested for effects of the herbicide acifluorfen on porphyrin accumulation in darkness and subsequent electrolyte leakage and photobleaching of chlo- rophyll after exposure to light. Protoporphyrin IX (Proto IX) was the only porphyrin that was substantially increased by the herbi- cide in any of the species. However, there was a wide range in the amount of Proto IX accumulation caused by 0.1 millimolar acifluorfen between species. Within species, there was a reduced effect of the herbicide in older tissues. Therefore, direct quanti- tative comparisons between species are difficult. Nevertheless, when data from different species and from tissues of different age within a species were plotted, there was a curvilinear rela- tionship between the amount of Proto IX caused to accumulate during 20 hours of darkness and the amount of electrolyte leak- age or chlorophyll photobleaching caused after 6 and 24 hours of light, respectively, following the dark period. Herbicidal dam- age plateaued at about 10 nanomoles of Proto IX per gram of fresh weight. Little difference was found between in vitro acifluor- fen inhibition of protoporphyrinogen oxidase (Protox) of plastid preparations of mustard, cucumber, and moming glory, three species with large differences in their susceptibility at the tissue level. Mustard, a highly tolerant species, produced little Proto IX in response to the herbicide, despite having a highly susceptible Protox. Acifluorfen blocked carbon flow from 6-aminolevulinic acid to protochlorophyllide in mustard, indicating that it inhibits Protox in vivo. Increasing 5-aminolevulinic acid concentrations (33-333 micromolar) supplied to mustard with 0.1 millimolar aci- fluorfen increased Proto IX accumulation and herbicidal activity, demonstrating that mustard sensitivity to Proto IX was similar to other species. Differential susceptibility to acifluorfen of the spe- cies examined in this study appears to be due in large part to differences in Proto IX accumulation in response to the herbicide. In some cases, differences in Proto IX accumulation appear to be due to differences in activity of the porphyrin pathway.
Pd Complex-Promoted Cyclopolymerization of Functionalized α,ω-Dienes and Copolymerization with Ethylene to Afford Polymers with Cyclic Repeating Units (2006)

The Pd(II)-diimine catalysts initiate cyclopolymerization of isopropylidene diallylmalonate (I) to produce the polymer containing trans-1,2-disubstituted cyclopentane groups. Use of Pd complexes with a C2-symmetric ligand afforded the polymer with highly regulated tacticity. The polymerization of isopropylidene diallylmalonate in ethylene atmosphere gives the polyethylene with up to 42% comonomer incorporation.
Cloning of a cDNA encoding cellobiose dehydrogenase, a hemoflavoenzyme from Phanerochaete chrysosporium (1996)

Cellobiose dehydrogenase (CDH) is an extracellular hemoflavoenzyme produced by cellulose-degrading cultures of the wood-degrading basidiomycete Phanerochaete chrysosporium. CDH contains one flavin adenine dinucleotide (FAD) and one heme b per molecule, and it oxidizes cellobiose to cellobionolactone. In this report, a 2.4-kb cDNA encoding CDH was isolated by screening an expression library of P. chrysosporium OGC101 with a CDH-specific polyclonal antibody. The cDNA encodes a 755-amino-acid protein with a predicted mass of 80,115 Da. Sequence analysis suggests that the heme domain is located at the N terminus and that the falvin domain is located at the C terminus. The flavin domain shows a beta 1-alpha A-beta 2 motif for FAD binding and has high sequence similarity to several FAD-dependent enzymes. Little sequence similarity to hemoflavoenzymes is found. CDH binds to cellulose similarly to cellulases. However, little sequence similarity is observed with the conserved cellulose-binding sequences of cellulases. This suggests that CDH might possess a specific sequence for cellulose binding which is different from that of cellulases. Northern (RNA) blot analysis of total RNA from cellulose-, glucose-, and cellobiose-grown P. chrysosporium indicated that CDH mRNA is produced only in cellulose-grown cells. This suggests that CDH expression is regulated at the transcriptional level by either cellulose or one of its degradation products. Southern blot analysis suggests the presence of only a single gene for CDH in P. chrysosporium OGC101.
REGISTRATION AND NORMALIZATION TECHNIQUES FOR ASSESSING BRAIN FUNCTIONAL IMAGES (2003)

Tc-99m HMPAO is a typical tracer used in the analysis of cerebral blood flow. Single photon emission computed tomography (SPECT) brain imaging utilizing Tc-99m HMPAO is thus a popular method to assess brain function. In this paper, we present an image analysis system for SPECT images that performs a series of image processing procedures including 3D image registration, gray-level normalization, and brain extraction, which map all the 3D brain data to the same space for further analysis. Afterward, the aligned images undertake a standard statistical analysis, the paired t test, to detect the areas that have significant deviations between the two images. The statistical t map is then represented with a color plot for each brain slice to indicate the activation foci. The resulting maps are found very helpful to doctors for the lesion evaluation and localization in the clinical diagnosis of schizophrenic patients.
Expression of human insulin-like growth factor-binding protein-3 in transgenic mice (1995)

Transgenic mice which expressed human IGF-binding protein-3 (hIGFBP-3) were generated by pronuclear injection of an hIGFBP-3 cDNA driven by the mouse metallothionein 1 promoter. Two of the seven founder mice had measurable levels of hIGFBP-3 in the circulation. The serum levels of hIGFBP-3 increased as the mice were bred to homozygosity and were further induced by supplementing the drinking water with 25 mM ZnCl2. While the birth weight, litter size and body weight of transgenic mice were not significantly different from non-transgenic litter mates or wild-type mice derived from the same genetic background, the transgenic mice demonstrated selective organomegaly. The spleen, liver and heart of mice derived from both founders were significantly heavier compared with organs from non-transgenic mice (P < 0.05, P < 0.005 and P < 0.01 respectively). The weights of the brain and kidney were similar in transgenic and non-transgenic mice. Expression of the transgene was detected in the kidney, small intestine and colon by Northern blot analysis. Western ligand blotting of serum from transgenic mice did not demonstrate any change in the abundance of the IGFBPs detected by this method. When serum from transgenic mice was incubated with 125I-labeled IGF-I and analyzed by Sephacryl S-200 chromatography under neutral conditions a significantly (P < 0.05) increased amount of the radioactivity was found in the 140 kDa ternary complex compared with serum from wild-type mice. Immunoreactive hIGFBP-3 was detected in the 140 kDa ternary complex but the majority of immunoreactive hIGFBP-3 present in transgenic mouse serum eluted in later fractions indicating that it was not associated with the acid-labile subunit. These data demonstrate that modest constitutive expression of hIGFBP-3 has a selective effect on organ growth and development. The establishment of these IGFBP-3 transgenic mouse strains may provide useful models to investigate further the physiological role of IGFBP-3.
Ibsen's Nora: The promise and the trap (1975)

The late nineteenth century Norwegian playwright Henrik Ibsen both guides and haunts the struggle for the emancipation of women. His play “A Doll's House” remains after nearly one hundred years a most eloquent statement of the urge to stand free. Nora, the play's heroine, has inspired countless women in their fight for liberation.
Decoding algebraic geometric codes (2002)

We present a new algorithm for decoding AG-codes significantly beyond the error-correction bound. Specifically, given a word y whose distance to the AG-code is at most e, where e is a parameter depending on the block length and the dimension of the code, our algorithm produces all codewords that have distance /spl les/e from y. We also discuss modifications of our general algorithm and show how to obtain similar algorithms for binary codes using concatenated codes.
Integrated adaptive robust control of active magnetic bearings (2002)

This paper presents an adaptive robust approach to control of active magnetic bearing (AMB) systems subjected to parametric uncertainties and external disturbances. The control design uses a sliding-mode method and therefore has the advantages of order reduction, disturbance rejection, insensitivity to parameter variation and simplicity of implementation. The design is based on the original nonlinear dynamic equations of the rotor and global stability of the closed loop system is guaranteed. The proposed approach integrates both adaptive and robust control where the adaptive design is used to cancel out the gravitational force and the force due to rotor mass imbalance and the robust design is used to compensate for other disturbances and improve the transient performance. Numerical simulations are provided to demonstrate the efficacy of the proposed control.
Effective inhibition of herpes simplex virus 1 gene expression and growth by engineered RNase P ribozyme (2001)

Using an in vitro selection procedure, we have previously isolated ribonuclease P (RNase P) ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, an M1GS RNA variant was used to target the mRNA encoding human herpes simplex virus 1 (HSV-1) major transcription activator ICP4. The variant is about 15 times more efficient in cleaving the ICP4 mRNA sequence in vitro than the ribozyme derived from the wild type RNase P ribozyme. Moreover, the variant is also more effective in inhibiting viral ICP4 expression and growth in HSV-1-infected cells than the wild type ribozyme. A reduction of approximately 90% in the expression level of ICP4 and a reduction of 4000-fold in viral growth were observed in cells that expressed the variant. In contrast, a reduction of <10% in the ICP4 expression and viral growth was observed in cells that either did not express the ribozyme or produced a catalytically inactive ribozyme mutant. These results provide direct evidence that RNase P ribozyme variants can be highly effective in inhibiting HSV-1 gene expression and growth and furthermore, demonstrate the feasibility of developing highly effective RNase P ribozyme variants for anti-HSV applications by using in vitro selection procedures.
Bile acid-induced negative feedback regulation of the human ileal bile acid transporter (2004)

Ileal expression of the apical sodium-dependent bile acid transporter (ASBT) in the rat is unaffected by bile salts, yet in the mouse it is under negative-feedback regulation. The bile acid responsiveness of human ASBT is unknown. The human ASBT promoter linked to a luciferase reporter was studied in Caco-2 cells treated with chenodeoxycholic acid (CDCA) and transfected with expression plasmids for farnesoid X-receptor (FXR), short heterodimer partner (SHP), and retinoic acid receptor/retinoid X receptor (RAR/RXR). CDCA treatment of Caco-2 cells led to a 75% reduction in steady-state ASBT messenger RNA levels and a 78% reduction in human ASBT promoter activity. A dominant negative FXR abrogated the response to CDCA. Site-directed mutagenesis of an RAR/RXR cis element in the human ASBT promoter reduced its activity by 50% and eliminated the bile acid response. Retinoic acid activated the human ASBT promoter fourfold. SHP repressed the activity of the ASBT promoter and reduced activation by retinoic acid. Antisense mediated knock-down of SHP in Caco-2 cells partially offset the bile acid mediated repression of ASBT promoter activity. In conclusion, the human ASBT is positively regulated by retinoic acid. Bile acids induce a negative feedback regulation of human ASBT via an FXR-mediated, SHP-dependent effect upon RAR/RXR activation of ASBT.
Resistant plants: Alfalfa variety resistant to aphid attack and adapted to desert areas planned (1955)

The Principles of genetics—basic to scientific plant breeding—are to be applied in a project in the Imperial Valley to develop a strain of alfalfa resitant to the yellow clover aphid and adapted to the growing conditions in the desert areas of the southwest.
Differential phosphodiesterase expression and cytosolic Ca<sup>2+</sup> in human CNS tumour cells and in non‐malignant and malignant cells of rat origin (2005)

A promising attempt in the field of tumour therapy is the modulation of intracellular, proliferation-associated signalling pathways. The role of cyclic nucleotide phosphodiesterases (PDEs), key enzymes in cAMP/cGMP signal transduction, was investigated in two human CNS tumour cell lines as well as in the rat glioblastoma cell line C6 in comparison with rat cerebellar astrocytes with the emphasis on target evaluation. We found differential PDE expression patterns in human CNS tumour cell lines as well as in CNS cells of rat origin. In human glioblastoma cells, intracellular cAMP and Ca(2+) levels correlated well with the PDE expression pattern. There were, however, marked differences in PDE expression and Ca(2+) kinetics between the human glioblastoma cell lines. In contrast to human epithelial tumour cells, shown earlier by us to express significantly enhanced cAMP-specific PDE activity, this was not the case in rat glioblastoma cells compared with non-malignant rat astrocytes. Despite different levels of PDE1 and PDE4 expression and activity, cyclic nucleotide and Ca(2+) levels in non-malignant and malignant rat CNS cells were similar. These in vitro data do not support the concept of PDE1C representing a target exploitable for drug treatment of malignant CNS tumours.
Ab Initio Calculation of Isotopic Fractionation in B(OH)<sub>3</sub>(aq) and BOH<sub>4</sub><sup>-</sup>(aq) (2007)

Ab initio molecular dynamics calculations are used here to calculate vibration frequencies for B(OH)3(aq) and B(OH)4-(aq). We show that previous calculations have either underestimated or omitted altogether a major fractionating vibrational mode. The new results indicate that the 11B partitions into B(OH)4- in water, in contrast to recent experimental measurement of the fractionation factor. The discrepancy appears to result from using finite-temperature vibrational frequencies in the standard harmonic expression for the fractionation factor. While our results connect the measured spectrum to previous harmonic electronic structure calculations, they indicate that harmonic frequencies must be extracted from experimental vibrational spectra before they can be used in the standard expressions.
The quantitative detection of aripiprazole and its main metabolite by using capillary-electrophoresis (2011)

CE method is a feasible method to measure aripiprazole level with relatively low price compared with other analytical techniques for clinical use.
March of Dimes White Paper on preterm birth: The global and regional toll (2009)

Preterm birth (birth before 37 weeks' gestation) has been an under-recognised and underfunded global health issue, partly because of a lack of data on the worldwide extent of the problem. This White Paper presents newly-published data on the global and regional toll of preterm birth provided by the Department of Reproductive Health and Research of the World Health Organization (RHR/WHO) as a first step in measuring the extent of preterm birth worldwide. March of Dimes and RHR/WHO expect that these data will serve as a catalyst for policy makers, researchers, donors, clinicians and the general public to address this major public health problem. A future report will provide country-specific rates and suggest strategies to reduce mortality and disability from preterm birth.
<title>A Survey Of Large Screen Displays For C<formula><sup><roman>3</roman></sup></formula> Applications</title> (1983)

systems. Techniques applicable to large screen display systems include projection cathoderay tubes, light valves and large area direct view flat -panel devices. The operationalcharacteristics, information on existing product line equipment and a description of newlarge screen devices, which are just entering the market or are in An advanced state ofdevelopment, are presented herein. This material is based upon the results of a survey ofmanufacturers of large screen display equipment for military and commercial applications.It has been augmented by on -site discussions with cognizant engineering personnel andmarketing managers. Improvements to existing equipment, cost information (both initial andoperating), and new technological advances in the field over the last five years arehighlighted.IntroductionGenerally, there is no universally accepted definition of a large screen display device,however, a definition can be proposed on the basis of screen viewing area. The viewing areaof the largest available cathode ray tube is approximately one square meter. Thus, anydisplay with a viewing area greater than one square meter will be considered a large screendisplay.In any system application, the need for a large screen display should be justified on thebasis of its advantages to the user. For example, in Military C systems large screendisplays are used to present critical information that can be viewed by groups of people,including command personnel, in large room applications. The systems are configured toallow personnel to move around, within reasonable limits, and still view the display. Whenit is necessary to meet these requirements, the large screen display can be considered acost effective and useful device. Once the justification for a large screen display hasbeen established, a system can be selected and implemented. In past systems a variety oftechniques have been proposed and tried, but it has been difficult, even within the presenttechnology, to develop a large screen display device which compares favorably with thesmaller conventional CRT terminals. The basic problems involve the cost of providing alarge screen display at a brightness, information rate, and resolution equivalent to that ofthe smaller CRT terminal whether or not color and /or monochrome display images are required.Large screen devices suitable for Military C3 applications in rooms with dispersedaudiences and ambients of 15 to 30 foot -candles must meet certain requirements to perform
Spectroscopic characterization of a new polymorph of metal-free phthalocyanine (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic characterization of a new polymorph of metal-free phthalocyanineJames H. Sharp and Marcel LardonCite this: J. Phys. Chem. 1968, 72, 9, 3230–3235Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/j100855a024https://doi.org/10.1021/j100855a024research-articleACS PublicationsRequest reuse permissionsArticle Views786Altmetric-Citations149LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effects of Berberine on Proliferation and Metastasis of Human Endometrial Carcinoma Cell Line Ishikawa (2011)

Objective To study the effect of Berberine on human endometrial carcinoma cell line Ishikawa.Methods The changes of cell proliferation of Ishikawa cells treated with Berberine were observed by using MTT assay.The cell cycle expressions were determined by flow cytometry.The concentration of IL-8 in the supenmatant fluid was measured by ELISA.And NF-кB p65 were determined by western blot assay.Results Berberine could inhibit the proliferation of Ishikawa cells in vitro significantly in a dose-and time-dependent manner(P0.05).The G0/G1 phase arrest was induced by treatment after 48 hours(P0.05).The concentration of IL-8 in the supenmatant fluid were decreased.Cellular NF-кB p65 levels decreased in Berberine-treated cells after 48 hours(P0.05).Conclusion Berberine could inhibit Ishikawa cell proliferation,induce G0/G1 phase arrest,and inhibit the metastasis of endometrial carcinoma by interfering with the NF-кB signaling pathway.
Online Allocation with Traffic Spikes (2015)

Motivated by Internet advertising applications, online allocation problems have been studied extensively in various adversarial and stochastic models. While the adversarial arrival models are too pessimistic, many of the stochastic (such as i.i.d or random-order) arrival models do not realistically capture uncertainty in predictions. A significant cause for such uncertainty is the presence of unpredictable traffic spikes, often due to breaking news or similar events. To address this issue, a simultaneous approximation framework has been proposed to develop algorithms that work well both in the adversarial and stochastic models; however, this framework does not enable algorithms that make good use of partially accurate forecasts when making online decisions. In this paper, we propose a robust online stochastic model that captures the nature of traffic spikes in online advertising. In our model, in addition to the stochastic input for which we have good forecasting, an unknown number of impressions arrive that are adversarially chosen.We design algorithms that combine an stochastic algorithm with an online algorithm that adaptively reacts to inaccurate predictions. We provide provable bounds for our new algorithms in this framework. We accompany our positive results with a set of hardness results showing that that our algorithms are not far from optimal in this framework. As a byproduct of our results, we also present improved online algorithms for a slight variant of the simultaneous approximation framework.
Knowledge Discovery Practices and Emerging Applications of Data Mining: Trends and New Domains (2010)

"This book introduces the reader to recent research activities in the field of data mining, covering association mining, classification, mobile marketing, opinion mining, microarray data mining, internet mining and applications of data mining on biological data, telecommunication and distributed databases" - Provided by publisher