gebhart/patrepeval huggingface dataset:
AN EFFICIENT AMIDE-FORMING REACTION USING TRIBUTYLTRICHLOROMETHYLPHOSPHONIUM CHLORIDE (2001)

An efficient and expeditious amide-forming reaction is described via a combination of tributylphosphine and carbon tetrachloride (in situ generation of tributyltrichloromethylphosphonium chloride) in the absence of tertiary amines.
DNA Adduct Structure–Function Relationships: Comparing Solution with Polymerase Structures (2007)

It has now been nearly two decades since the first solution structures of DNA duplexes covalently damaged by metabolically activated polycyclic aromatic hydrocarbons and amines were determined by NMR. Dozens of such high-resolution structures are now available, and some broad structural themes have been uncovered. It has been hypothesized that the solution structures are relevant to the biochemical processing of the adducts. The structural features of the adducts are considered to determine their mutational properties in DNA polymerases and their repair susceptibilities. In recent years, a number of crystal structures of DNA adducts of interest to our work have been determined in DNA polymerases. Accordingly, it is now timely to consider how NMR solution structures relate to structures within DNA polymerases. The NMR solution structural themes for polycyclic aromatic adducts are often observed in polymerase crystal structures. While the polymerase interactions can on occasion override the solution preferences, intrinsic adduct conformations favored in solution are often manifested within polymerases and likely play a significant role in lesion processing.
Mesomorphous polyelectrolyte‐surfactant complexes (1995)

Polyelectrolyte–surfactant complexation allows the design and synthesis of a variety of highly ordered materials (sch as that modeled in the Figure). The variation of the polyelectrolyte and surfactant properties enables the tuning of the mechanical, electrical, and optical properties of the materials. The highly ordered media produced could be combined with a number of functional componentn (e.g., NLO dyes, conducting subunits, or gas selective groups) magnified image .
ML frame synchronization for the Gaussian channel with ISI (2002)

The problem of locating a periodically inserted frame synchronization pattern in random data for a binary pulse amplitude modulated (PAM) digital communication system over an additive white Gaussian noise (AWGN) channel with intersymbol interference (ISI) is considered. The optimum maximum-likelihood (ML) decision rule for frame synchronization over an AWGN channel with ISI is derived. The performances of an ordinary correlation rule are compared with those of the ML rule. A high SNR (signal-to-noise ratio) approximation to the ML rule, which can be implemented as simply as the correlation rule, is also derived.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Large Scale Experimental Evaluation to Methane Hydrate Dissociation below Quadruple Point by Depressurization Assisted with Heat Stimulation (2017)

The Pilot-Scale Hydrate Simulator (PHS), a three-dimensional 117.8 L pressure vessel, is applied to study the methane hydrate dissociation below the quadruple point in the sandy sediment in this work. The hydrate dissociation behaviors below and above the quadruple point by depressurization method and depressurization assisted with heat stimulation method are compared. The results indicate that methane hydrate dissociation below the quadruple point causes ice formation, which can strongly enhance the dissociation rate of the hydrate. The water generated from hydrate dissociation below the quadruple point may immediately form ice. Meanwhile, the hydrate dissociation below the quadruple point consumes the latent heat released by ice formation. In addition, it is found by depressurization assisted with heat stimulation that the heat injection has little influence on hydrate dissociation, because the injected heat is used for ice melting rather than hydrate dissociation.
An Analysis of 17 Catatonic Patients Diagnosed With Neuroleptic Malignant Syndrome (2000)

This study was conducted to show that catatonia is a predisposing factor for neuroleptic malignant syndrome (NMS) and to review the nosological relationship between catatonia and NMS. Seventeen consecutive cases of NMS were analyzed prospectively with reference to clinical and investigative findings before and after exposure to a neuroleptic. The series comprised eight males and nine females, ranging in age from 18 years to 65 years. Prior to neuroleptic exposure, all patients exhibited features compatible with criteria for catatonia (mutism/excitement) according to the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised, (DSM-III-R). Following neuroleptic administration (single dose in nine cases), patients deteriorated into a febrile, rigid, and obtunded state accompanied by autonomic dysfunction and raised creatine phosphokinase levels. These features were consistent with a diagnosis of NMS. Neuroleptics were discontinued and supportive medical treatment instituted. Benzodiazepines were beneficial in eight cases in relieving stupor, but bromocriptine and dantrolene were generally ineffective. In all patients diagnosed with NMS in the authors' series, catatonia was an invariable prodromal state. It appears that the administration of a neuroleptic intensified the preexisting catatonic state and precipitated a malignant variant of the disorder, which is currently recognized as NMS. The authors, therefore, challenge the separate nosological status of NMS and catatonia and suggest that these syndromes are part of a unitary pathophysiological disorder.
Plasma and urinary endothelin&hyphen;1 in focal segmental glomerulosclerosis (2001)

The kidney is an important site of endothelin-1 (ET-1) production and is particularly susceptible to ET-1 action. Infusion of ET-1 in rats induces both functional and morphological alterations in the kidneys. Increased plasma level of ET-1 has been reported in patients with chronic renal failure. However, there are still no reports on the plasma and urinary ET-1 levels in patients with focal segmental glomerulosclerosis (FSGS). In the present study, we have measured the plasma concentration and urinary excretion rate of ET-1 in 15 patients with nephrotic syndrome due to FSGS, and observed the serial changes of plasma and urinary ET-1 in nephrotic rats with FSGS, induced by repeated injection with puromycin aminonucleoside (PAN). ET-1 was measured with radioimmunoassay. The results showed that plasma ET-1 concentration in FSGS patients was significantly higher than in normal controls (P < 0.05), and that urinary ET-1 excretion rate was also significantly higher in FSGS patients than in normal controls (P < 0.01). In FSGS patients, the plasma and urinary ET-1 was significantly correlated (P < 0.05), and the urinary ET-1 excretion rate was significantly correlated with the amount of proteinuria (P < 0.05) and the glomerular sclerosing score (P < 0.01). In the ten rats with PAN-induced FSGS, serial examination showed a significant increase in plasma ET-1 after 8 weeks of injections, while the urinary ET-1 excretion rate showed a biphasic increase that showed a peak after 4 to 6 weeks. The same changes in plasma and urinary ET-1 levels were not observed in control rats injected with normal saline at the same frequency. Our results suggest that ET-1 may be involved in the pathogenesis of FSGS in both humans and rats.
Substituent effects on the carbon-13 spectra of oxindoles (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent effects on the carbon-13 spectra of oxindolesPaul G. Gassman, David P. Gilbert, and Tien-Yau LuhCite this: J. Org. Chem. 1977, 42, 8, 1340–1344Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/jo00428a015https://doi.org/10.1021/jo00428a015research-articleACS PublicationsRequest reuse permissionsArticle Views345Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Supramolecular Approach to Organic Alloys: Cocrystals and Three‐ and Four‐Component Solid Solutions of 1,4‐Diazabicyclo[2.2.2]octane and 4‐X‐Phenols (X=Cl, CH<sub>3</sub>, Br) (2007)

Triple play: The crystallization of 1,4-diazabicyclo[2.2.2]octane (A) with one, two, or three different 4-substituted phenols (B, C, D) leads to cocrystals (for example, AB2, left) or solid solutions (for example, A(B,C,D)2, right). The repeat units of these multicomponent organic solids are supramolecular assemblies of three molecules. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604830_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Infection of Turkeys with Histomonas meleagridis by the Cloacal Drop Method (2004)

The infection of turkeys with Histomonas meleagridis was attempted in the absence of its normal vector Heterakis gallinarum, using several experimental techniques. Battery-reared poults were inoculated at 2 wk of age with histomonads cultured in vitro, by several routes, including (a) per os (PO), (b) intradoacal (CI), and (c) cloacal drop (CD). Feed restriction was also studied as a predisposing factor. Intracloacal inoculation (CI) consistently produced severe infections in all experiments. In several experiments, turkeys did not become infected after inoculation PO with 1 x 10(5) cultured histomonads. Feed restriction prior to inoculation did not make turkeys susceptible to infection inoculated PO. However, when liquid cultures containing histomonads were applied to the vent (CD) and the dorsal lip stimulated to initiate cloacal drinking, the histomonads were taken into the cloaca and transported to the ceca by retrograde peristalsis. Heavy infections were produced by this method, with severe liver and cecal lesions recorded when birds were necropsied 12 days later. These results suggest that CD may provide ready entry into the lower intestinal tract for these parasites and may facilitate spread of infection through flocks.
Dual Myxovirus Screen Identifies a Small-Molecule Agonist of the Host Antiviral Response (2013)

As we are confronted with an increasing number of emerging and reemerging viral pathogens, the identification of novel pathogen-specific and broad-spectrum antivirals has become a major developmental objective. Targeting of host factors required for virus replication presents a tangible approach toward obtaining novel hits with a broadened indication range. However, the identification of developable host-directed antiviral candidates remains challenging. We describe a novel screening protocol that interrogates the myxovirus host-pathogen interactome for broad-spectrum drug candidates and simultaneously probes for conventional, pathogen-directed hits. With resource efficiency and pan-myxovirus activity as the central developmental parameters, we explored coscreening against two distinct, independently traceable myxoviruses in a single-well setting. Having identified a pair of unrelated pathogenic myxoviruses (influenza A virus and measles virus) with comparable replication kinetics, we observed unimpaired coreplication of both viruses, generated suitable firefly and Renilla luciferase reporter constructs, respectively, and validated the protocol for up to a 384-well plate format. Combined with an independent counterscreen using a recombinant respiratory syncytial virus luciferase reporter, implementation of the protocol identified candidates with a broadened antimyxovirus profile, in addition to pathogen-specific hits. Mechanistic characterization revealed a newly discovered broad-spectrum lead that does not block viral entry but stimulates effector pathways of the innate cellular antiviral response. In summary, we provide proof of concept for the efficient discovery of broad-spectrum myxovirus inhibitors in parallel to para- and orthomyxovirus-specific hit candidates in a single screening campaign. The newly identified compound provides a basis for the development of a novel broad-spectrum small-molecule antiviral class.
Hypoxia in the thymus: role of oxygen tension in thymocyte survival (2002)

Our previous studies using oxygen microelectrodes showed that the thymus is grossly hypoxic under normal physiological conditions. We now have investigated how oxygen tension affects the thymus at the cellular and molecular level. Adducts of the hypoxia marker drug pimonidazole accumulated in foci within the cortex and medulla and at the corticomedullary junction, consistent with the presence of widespread cellular hypoxia in the normal thymus. Hypoxia-associated pimonidazole accumulation was decreased but not abrogated by oxygen administration. Genes previously reported to be induced by hypoxia were expressed at baseline levels in the normal thymus, indicating that physiological adaptation to hypoxia occurred. Despite changes in thymus size and cellularity, thymic PO(2) did not change with age. Combined assays for hypoxia and cell death showed that hypoxia achieved using either hypoxic gas mixtures or high-density culture in normoxia decreased spontaneous thymocyte apoptosis in vitro. Taken together, these data suggest that regulatory mechanisms exist to maintain thymic cellular hypoxia in vivo and that oxygen tension may regulate thymocyte survival both in vitro and in vivo.
High frequency, soft transitions converter (2002)

A high efficiency, high power density power conversion topology is presented. This topology is compatible with higher output voltage applications such as 24 V and 48 V, where Schottky rectifiers cannot be used. The converter combines zero voltage switching across the primary switches, continuous energy transfer from the primary to the secondary and soft commutations of the output rectifiers. The soft switching of the output rectifiers minimizes the reverse recovery losses associated with ultrafast rectifiers operating at high frequency. An experimental converter using this concept is evaluated. The converter operates from an input voltage of 200 V to 430 V at 300 kHz, providing 400 W (50 V at 8 A) with efficiency of 95% at full load.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Triazole, Benzotriazole and Naphthotriazole as Corrosion Inhibitors for Copper (1975)

The use of triazole, benzotriazole, and naphthotriazole as corrosion inhibitors for copper is briefly reviewed. The corrosion of copper immersed in acidic, neutral, and alkaline solutions containing these compounds is reported. Triazole has generally been found to be a poor inhibitor, while benzotriazole and naphthotriazole are much better, with naphthotriazole giving the best protection. When used as a pretreatment for copper surfaces, all three inhibitors increase the time before atmospheric staining occurs, naphthotriazole is better than benzotriazole, and both are better than triazole.
Principle and application of Laser Radar (2013)

High density LiDAR is a Advanced active remote Sensing Technology so can obtain high density 3 D point cloud information a Object efficient ly and quicklywith Fast , Accurate then non-contact advantages . This paper describes , measuring principle a High density LiDAR and The characteristics of 3 kinds The scanningmethods. Analysis Was conducted on the accuracy Difference between Artificial Precision Measurement and 3D Laser scanning Measurement To tree DBH andvolume by experiment. Finally , This paper discusses the future Development trend of This Technology .
A new zero voltage and zero current power-switching technique (1992)

Work on a new converter topology whose advantage is that the power switching occurs at both zero current and zero voltage, giving it major advantages over the present state of the art, is reported. The application of this topology to both high- and low-output voltage converters is described in detail. Design details and test results are given, together with a full analysis of the operation of the converters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High hepatitis B virus load is associated with hepatocellular carcinomas development in Chinese chronic hepatitis B patients: a case control study (2012)

HBV-related HCC patients had higher HBV DNA level than non-HCC counterparts. Our findings imply that active HBV replication is associated with the HCC development.
Is 5G Ready for Drones: A Look into Contemporary and Prospective Wireless Networks from a Standardization Perspective (2019)

There are two main questions regarding the interaction of drones with wireless networks: first, how wireless networks can support personal or professional use of drones, and second, how drones can support wireless network performance (i.e., boosting capacity on demand, increasing coverage range, enhancing reliability and agility as an aerial node). From a communications perspective, this article categorizes drones in the first case as mobile-enabled drones (MEDs) and drones in the second case as wireless infrastructure drones (WIDs). At the dawn of 5G Release-16, this study investigates both the MED and WID cases within the realistic constraints of 5G. Furthermore, we discuss potential solutions for highlighted open issues, either via application of current standards or by providing suggestions toward further enhancements. Although integrating drones into cellular networks is a rather complicated issue, 4G LTE-A and the 5G Rel-15 standards seem to have significant accomplishments in building fundamental mechanisms. Nevertheless, finetuning future releases by studying existing methods from the aspects of MEDs and WIDs, and bridging the gaps with new techniques are still needed.
Changes in superior sagittal sinus pressure in children with head elevation, jugular venous compression, and PEEP (1986)

Air embolism is a potential hazard during craniotomy whenever intracranial venous pressure is subatmospheric. In order to better understand both the risk of air embolism and its treatment in neurosurgical patients, the authors have investigated the relationship of superior sagittal sinus pressure (SSP) to head position in 15 children and examined the effects of both jugular venous compression and positive end-expiratory airway pressure (PEEP) on SSP. Progressive head elevation significantly decreased mean SSP and, in five patients, SSP was less than 0 mm Hg at 90 degrees torso elevation. A PEEP of 10 cm H2O was ineffective in significantly increasing SSP at any degree of head elevation, whereas bilateral internal jugular compression always caused a significant increase in SSP. The authors conclude that children are at risk for venous air embolism when undergoing suboccipital craniectomy in the sitting position because intracranial venous pressure is often subatmospheric when the head is elevated. Furthermore, maintaining PEEP does not appear to be a reliable treatment for increasing SSP, whereas bilateral internal jugular compression is effective.
Surface Modification of Ag Coated Cu Conductive Metal Powder for Conductive Silicone Sealant Gasket Paste (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
SOLAR DESALINATION OF BRACKISH WATER USING MEMBRANE DISTILLATION PROCESS (2008)

Shortage of fresh water supply in New Mexico and southwestern parts of the U.S. is becoming an increasingly important and challenging problem. The objectives of this research are: evaluating technical and economic feasibility of solar desalination technology based on membrane distillation for New Mexico brackish water; assessing the feasibility of removing trace contaminants including arsenic, fluoride and nitrate from brackish water in the membrane distillation desalination process; developing a cost-effective solar desalination process for New Mexico brackish water using membrane distillation technology; Obtaining process data for process scale up and design for commercial solar desalination plant and recommending membrane distillation solar desalination technology for the State of New Mexico.
Tumor Regression Induced by Intratumor Therapy with a Disabled Infectious Single Cycle (DISC) Herpes Simplex Virus (HSV) Vector, DISC/HSV/Murine Granulocyte-Macrophage Colony-Stimulating Factor, Correlates with Antigen-Specific Adaptive Immunity (2002)

Direct intratumor injection of a disabled infectious single cycle HSV-2 virus encoding the murine GM-CSF gene (DISC/mGM-CSF) into established murine colon carcinoma CT26 tumors induced a significant delay in tumor growth and complete tumor regression in up to 70% of animals. Pre-existing immunity to HSV did not reduce the therapeutic efficacy of DISC/mGM-CSF, and, when administered in combination with syngeneic dendritic cells, further decreased tumor growth and increased the incidence of complete tumor regression. Direct intratumor injection of DISC/mGM-CSF also inhibited the growth of CT26 tumor cells implanted on the contralateral flank or seeded into the lungs following i.v. injection of tumor cells (experimental lung metastasis). Proliferation of splenocytes in response to Con A was impaired in progressor and tumor-bearer, but not regressor, mice. A potent tumor-specific CTL response was generated from splenocytes of all mice with regressing, but not progressing tumors following in vitro peptide stimulation; this response was specific for the gp70 AH-1 peptide SPSYVYHQF and correlated with IFN-gamma, but not IL-4 cytokine production. Depletion of CD8(+) T cells from regressor splenocytes before in vitro stimulation with the relevant peptide abolished their cytolytic activity, while depletion of CD4(+) T cells only partially inhibited CTL generation. Tumor regression induced by DISC/mGM-CSF virus immunotherapy provides a unique model for evaluating the immune mechanism(s) involved in tumor rejection, upon which tumor immunotherapy regimes may be based.
Novel LTPS technology for large substrate (2016)

We developed partial laser anneal silicon (PLAS) thin‐film transistor (TFT) of novel low‐temperature polycrystalline‐silicon (LTPS) technology, which had the mobility of 28.1 cm 2 /Vs lager than that of mass produced oxide TFT and photo‐stability comparable with that of LTPS TFT in bottom gate structure. This innovative technology enables the conversion from an α‐Si TFT to a high‐mobility TFT most easily and inexpensively. Moreover, there is no limit of substrate size, such as Gen10 and more. Photo‐stability of PLAS will be suitable to organic light‐emitting diode backplane, high‐dynamic range TV, and outdoor IDP.