gebhart/patrepeval huggingface dataset:
Accuracy of digital templating in total knee arthroplasty. (2012)

Preoperative planning is an important aspect of total joint arthroplasty. Although significant attention has been given to how total hip arthroplasty templates are magnified, total knee arthroplasty (TKA) digital templating magnification methods have not been compared. In this study, 50 patients undergoing TKA by the same surgeon were digitally templated using 2 common digital magnification methods to determine if there is any difference in accuracy or precision. Radiographs were randomly chosen to include a 25-mm magnification marker (MM) at the level of the joint or no magnification marker with uniform 115% magnification (NM). There was no statistical difference between templated and actual component sizes. Preoperative templating determined the exact component size in 64% of femurs and 60% of tibias using the NM technique. Femurs were slightly oversized (mean, 0.2 femur size), whereas tibias had no such trend. In MM templating, 52% of femurs and 48% of tibias were exact. Various methods of digital templating-the new standard of preoperative templating-provide no clear advantage over one another. The benefit of templating in TKA appears to be 2-fold: the surgeon can reliably predict a range of implant sizes needed and can ascertain a reliable starting point in determining implant size and position.
Geomicrobiology (2008)

Uncovers the Key Role Microbes Play in the Transformation of Oxidizable and Reducible MineralsMany areas of geomicrobial processes are receiving serious attention from microbiologists, specifically the role microbes play in the formation and degradation of minerals and fossil fuels and elemental cycling. Most notably, the latest research finds that
Unusual cause for an increase of the sensing integrity counter in a patient with inappropriate implantable cardioverter-defibrillator therapy (2007)

We describe the case of a patient who presented with multiple implantable cardioverter-defibrillator (ICD) shock discharges 12 months after device implantation. Upon device interrogation, intermittent oversensing of electrical noise and potential ICD lead failure were suggested by a significant increase in the sensing integrity counter (SIC), a cumulative count of very short ventricular sensed intervals. Analysis of stored episodes, however, revealed that inappropriate ICD therapy had been caused by intermittent T-wave oversensing (TWO), and that the increase of the SIC resulted from the coincidence of TWO and premature ventricular complexes (PVCs). T-wave oversensing resolved and the SIC did not increase any more during follow-up after adjustment of ventricular sensitivity. The coincidence of TWO and PVCs should therefore be considered as an uncommon cause for short ventricular sensed intervals in ICD patients presenting with a suspect increase in the SIC.
Isolation of pyroGlu-Gly-Arg-Phe-NH2 (Antho-RFamide), a neuropeptide from sea anemones. (1986)

A radioimmunoassay has been developed for peptides containing the carboxyl-terminal sequence Arg-Phe-NH2 (RFamide). Using this radioimmunoassay and applying cation-exchange chromatography and HPLC, we have isolated an RFamide peptide from acetic acid extracts of the sea anemone Anthopleura elegantissima. Three different methods established that the structure of the Anthopleura RFamide peptide (Antho-RFamide) is pyroGlu-Gly-Arg-Phe-NH2. Comparison of synthetic and natural Antho-RFamide and their enzymatic breakdown products on six different HPLC columns confirmed the structure of the sea anemone peptide. Using synthetic Antho-RFamide as a standard in our radioimmunoassay, we measured high concentrations (3.2 nmol/g wet weight) of this peptide in extracts of Anthopleura. It is proposed that Antho-RFamide is a transmitter at neuromuscular synapses in sea anemones.
Spectral band selection and classifier design for a multispectral imaging laser radar (1998)

A statistical spectral band selection procedure and classifiers for an active multispectral laser radar (LADAR) sensor are described. The sensor will operate in the 1 to 5 xm wavelength region. The algorithms proposed are tested using library reflectance spectra for some representative background materials. The material classes considered include both natural (vegetation and soil) and man-made (camouflage cloth and tar-asphalt). The analysis includes noise statistics due to Gaussian receiver noise and target induced speckle variations in the LADAR return signal intensity. The results of this analysis are then directly applied to an artificially generated spatial template of a scene consisting of these four material classes. The performance of four different classifier algorithms, which include a minimum distance classifier, a log- domain minimum distance classifier, a Bayes speckle-only classifier, and a Bayes speckle-Gaussian classifier, are evaluated. We show that the Bayesian classifier designed for speckle and Gaussian noise statistics outperforms the other classifiers. Our results also indicate that even when exact knowledge of the observation model is available, the classifier performance for speckled images can be poor unless the number of integrated speckle cells is large.
Design of AB divinyl “template monomers” toward alternating sequence control in metal-catalyzed living radical polymerization (2010)

For alternating repeat-unit sequence via living radical polymerization, “template monomers” were designed and polymerized, where two polymerizable alkene (vinyl) functions [e.g., methacrylate (M) and acrylate (A)] were placed side by side at the 1,8-positions on a rigid naphthalene scaffold. Even for such a divinyl monomer, highly selective intramolecular radical propagation was achieved with metal-catalyzed living radical polymerization systems, to give linear controlled polymers without cross-linking. The naphthalene template was cleaved viahydrolysis from the resultant polymer, and subsequently methylated for sequence characterization. 1H NMR analysis demonstrated that the polymers consisted of highly alternating sequences (A-M-A: >80%), practically free from homo triad sequences (M-M-M).
The RF Thermoseed-A Thermally Self-Regulating Implant for the Production of Brain Lesions (1971)

Telethermocoagulation is a neurosurgical technique that is now entering the phase of practical clinical application. In this system brain lesions are produced by heating implanted metallics by an external RF electromagnetic field.
Textured digital elevation model formation from low-cost UAV LADAR/digital image data (2015)

Textured digital elevation models (TDEMs) have valuable use in precision agriculture, situational awareness, and disaster response. However, scientific-quality models are expensive to obtain using conventional aircraft-based methods. The cost of creating an accurate textured terrain model can be reduced by using a low-cost (<$20k) UAV system fitted with ladar and electro-optical (EO) sensors. A texel camera fuses calibrated ladar and EO data upon simultaneous capture, creating a texel image. This eliminates the problem of fusing the data in a post-processing step and enables both 2D- and 3D-image registration techniques to be used. This paper describes formation of TDEMs using simulated data from a small UAV gathering swaths of texel images of the terrain below. Being a low-cost UAV, only a coarse knowledge of position and attitude is known, and thus both 2D- and 3D-image registration techniques must be used to register adjacent swaths of texel imagery to create a TDEM. The process of creating an aggregate texel image (a TDEM) from many smaller texel image swaths is described. The algorithm is seeded with the rough estimate of position and attitude of each capture. Details such as the required amount of texel image overlap, registration models, simulated flight patterns (level and turbulent), and texture image formation are presented. In addition, examples of such TDEMs are shown and analyzed for accuracy.
Biomechanical Study on the Effect of Cervical Spine Fusion on Adjacent-Level Intradiscal Pressure and Segmental Motion (2002)

Clinical studies have reported increased rates of disc degeneration at levels adjacent to fusion. It is believed that eliminating motion through fusion shifts the load to the adjacent levels, causing earlier disc degeneration. This study has shown that significant increases in intradiscal pressure and segmental motion occur at levels adjacent to fusion during normal range of motion. These results may partially explain the mechanism of early disc degeneration at levels adjacent to cervical spine fusion.
Organic ions in the gas phase. XXVII. Long-range intramolecular interactions in 4-n-alkyl trimellitic esters (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic ions in the gas phase. XXVII. Long-range intramolecular interactions in 4-n-alkyl trimellitic estersSeymour. Meyerson, Imre. Puskas, and Ellis K. FieldsCite this: J. Am. Chem. Soc. 1973, 95, 18, 6056–6067Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/ja00799a037https://doi.org/10.1021/ja00799a037research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: A NEW CLASS OF POTENT GUANINE ANTIMETABOLITES, SYNTHESIS OF 3‐DEAZAGUANINE, 3‐DEAZAGUANOSINE, AND 3‐DEAZAGUANYLIC ACID BY A NOVEL RING CLOSURE OF IMIDAZOLE PRECURSORS (1975)

Abstract Das durch Erhitzen des Carbamoylimidazols (Ia) mit Phosphoroxychlorid erhältliche Nitril (Ib) geht bei 8 Tage langem Behandeln mit flüssigem Ammoniak bei 100°C in das Deazaguanidin (III) über [das Zwischenprodukt (II) läßt sich nach 2 Tagen abfangen].
CO2-Binding-Organic-Liquids-Enhanced CO2 Capture using Polarity-Swing-Assisted Regeneration (2013)

A new solvent-based CO2 capture process couples the unique attributes of non-aqueous, CO2-binding organic liquids (CO2BOLs) with the newly discovered polarity-swing-assisted regeneration (PSAR) process that is unique to switchable ionic liquids. Laboratory measurements with PSAR indicate the ability to achieve a regeneration effect at 75 °C compared to a temperature of 120 °C using thermal regeneration only. Initial measurements also indicate the kinetic behavior of CO2 release is also improved with PSAR.
The Synthesis of Rotaxane Probes for Magnetic Resonance Imaging (MRI) (2016)

Rotaxanes are simple molecules made by an interaction between a host and a guest.1 Research has shown that rotaxanes have the capability of exchanging a hyperpolarized inert gas atom for use in Magnetic Resonance Imaging (MRI).2 Currently, MRI contrast is enhanced by the injecting a magnetic gadolinium (III) [Gd(III)] ions into the human body prior to the imaging experiment.3 Unfortunately, these contrast agents are expensive and toxic; as a result, there is need for a cheaper and less toxic imaging agent. Additionally, it would be beneficial to develop targeted contrast agents, i.e. macromolecules that bind specific analytes, proteins, or cellular receptors within the body. By combining rotaxanes with Hyperpolarized 129Xe Chemical Exchange Saturation Transfer (HyperCEST), 129Xe MRI technology should be capable of imaging specific areas in the human anatomy, thus facilitating the study and diagnosis of diseases or injuries. Currently 129Xe MRI is being used to genertate images of the lungs and the brain, but with a synthetic molecule we hope to broaden this capability to include high-resolution molecular imaging. The manuscript, “Cyclodextrin-based Pseudo-rotaxanes: An Easily Conjugatable Scaffold for Hyperpolarized Xenon Magnetic Resonance Imaging Biosensors” is the result of our preliminary work to develop a viable molecular probe. The manuscript focuses on the development of a new class of xenon-129 MRI contrast agents based on rotaxanes of γ-cyclodextrin, and the application of this new technology to the synthesis of a potential biosensor for imaging the β-amyloid plaques that are associated with Alzheimer’s disease.
'Money, for the night is coming': Jean Rhys and Gendered Economies of Ageing (2001)

The published collection of Jean Rhys's correspondence opens with two undated photographs of Rhys on facing pages. The author's pose is nearly identical in the two images: her head rests on her hands and her large, dark eyes, rimmed with black liner, look directly out at the viewer. In both pictures, Rhys's hairstyle is exactly the same - though the colour and texture have changed - and the vivid pattern on her clothing is also similar. Both are portraits of a strikingly beautiful woman, and together they suggest a narrative embodying several concerns central to Rhys's early fiction: the exhibition of feminine beauty, the passing of time, and the social, biological and economic consequences of ageing for women. The strong continuities between the two photos, along with their striking differences, serve as a visual representation of the need for women to appear unchanging, to weave a narrative or create an image of the self that keeps the past and present contemporaneous in order to maintain value in the sexual marketplace. The inter-relations of gender, value, age and expenditure suggested by the two photographs are articulated in Jean Rhys's early novels, which depict the economy of investment and loss that women face as they age. In Rhys's texts - and particularly in her two first-person narratives - there is an attempt to recreate in prose the simultaneous experience of past and present, not simply as an example of modernist experimentation with narrative continuity, but also as a specifically gendered response to the economic and social consequences of ageing for women.
Dynamic Regulation of Platelet-derived Growth Factor D (PDGF-D) Activity and Extracellular Spatial Distribution by Matriptase-mediated Proteolysis (2015)

The oncogenic roles of PDGF-D and its proteolytic activator, matriptase, have been strongly implicated in human prostate cancer. Latent full-length PDGF-D (FL-D) consists of a CUB domain, a growth factor domain (GFD), and the hinge region in between. Matriptase processes the FL-D dimer into a GFD dimer (GFD-D) in a stepwise manner, involving generation of a hemidimer (HD), an intermediate product containing one FL-D subunit and one GFD subunit. Although the HD is a pro-growth factor that can be processed into the GFD-D by matriptase, the HD can also act as a dominant-negative ligand that prevents PDGF-B-mediated β-PDGF receptor activation in fibroblasts. The active GFD-D can be further cleaved into a smaller and yet inactive form if matriptase-mediated proteolysis persists. Through mutagenesis and functional analyses, we found that the R(340)R(341)GR(343)A (P4-P1/P1') motif within the GFD is the matriptase cleavage site through which matriptase can deactivate PDGF-D. Comparative sequence analysis based on the published crystal structure of PDGF-B predicted that the matriptase cleavage site R(340)R(341)GR(343)A is within loop III of the GFD, a critical structural element for its binding with the β-PDGF receptor. Interestingly, we also found that matriptase processing regulates the deposition of PDGF-D dimer species into the extracellular matrix (ECM) with increased binding from the FL-D dimer, to the HD, and to the GFD-D. Furthermore, we provide evidence that R(340)R(341)GR(343)A within the GFD is critical for PDGF-D deposition and binding to the ECM. In this study, we report a structural element crucial for the biological function and ECM deposition of PDGF-D and provide molecular insight into the dynamic functional interplay between the serine protease matriptase and PDGF-D.
Catalysis and chiral recognition through designed complexation of transition states in transacylations of amino ester salts (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis and chiral recognition through designed complexation of transition states in transacylations of amino ester saltsY. Chao and Donald J. CramCite this: J. Am. Chem. Soc. 1976, 98, 4, 1015–1017Publication Date (Print):February 1, 1976Publication History Published online1 May 2002Published inissue 1 February 1976https://pubs.acs.org/doi/10.1021/ja00420a026https://doi.org/10.1021/ja00420a026research-articleACS PublicationsRequest reuse permissionsArticle Views578Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Correlation between CMIA and TPPA methods in detecting treponema antibody (2012)

Objective To investigate the positive rates of TPPA method when S/CO value of chemiluminescence 1 in detection of syphilis,and provide a more accurate laboratory evidence for the clinical diagnosis and treatment of syphilis.Methods Treponema antibody in sera of patients was detected by CMIA and TPPA methods respectively.Results Treponema antibody in sera of 200 patients with S/CO value 1 of chemiluminescence was all negative when detected by TPPA.Positive rates of serum treponema antibody in patients with S/CO value of chemiluminescence ranged from 1 to 4.99,5 to 9.99,10 to 19.99 and ≥20 were 68.65%(346/504),97.47%(231/237),99.08%(433/437) and 100%(838/838) detected by TPPA respectively.Conclusion Chemiluminescence is a highly sensitive and automated method in detection of syphilis,and suitable for clinical routine screening of a large number of specimens.Combination of chemiluminescence with TPPA is recommended when S/CO value of chemiluminescence is between 1 and 19.99 in detection of syphilis in order to reduce the false positive possibility in detection of syphilis and provide the more accurate laboratory evidence for the clinical diagnosis and treatment of syphilis.
Side‐chain Liquid Crystalline Polyesters for Optical Information Storage (1996)

Azobenzene side-chain liquid crystalline polyester structures suitable for permanent optical storage are described. The synthesis and characterization of the polyesters together with differential scanning calorimetry and X-ray investigations are discussed. Optical anisotropic investigations and holographic storage in one particular polyester are described in detail and polarized Fourier transform infrared spectroscopic data complementing the optical data are presented. Optical and atomic force microscope investigations point to a laser-induced aggregation as responsible for permanent optical storage.
In vivo modulation of hematopoiesis by a novel hematoregulatory peptide. (1994)

The hematoregulatory peptide dimer, HP5B, enhances myelopoiesis by stimulating stromal cell cytokine production. However, the disulfide bridge of this peptide is susceptible to reduction, leading to the formation of monomeric pentapeptide, HP5, a direct-acting inhibitor of myelopoiesis. We have replaced the disulfide (S-S) bond of HP5B dimer with an isosteric ethylene (CH2-CH2) group, creating a new, nonreducible, metabolically more stable peptide (SK&F 107647). This novel peptide was tested in vitro and in vivo for hematopoietic effects. In vitro, SK&F 107647 has no direct colony-stimulating activity (CSA). Stimulation of murine stromal cells with SK&F 107647 results in production and release of CSA at concentrations as low as 0.01 ng/mL, at least 10-fold lower than observed with HP5B dimer. Injection of SK&F 107647 in normal mice results in a two- to six-fold increase in serum CSA, which becomes maximal at 6 hours postinjection. Administration of peptide daily over 4 days (q.d. x 4) by both parenteral and oral routes results in significant increases in absolute numbers of granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells, as well as stimulating their cell cycle rates. A doubling in day 8 CFU-S was also observed in SK&F 107647-treated mice. Continuous subcutaneous (s.c.) infusion of SK&F 107647 in femorally cannulated rats demonstrated modest but significant elevation of peripheral blood neutrophil and monocyte counts within 7 days. SK&F 107647 represents a novel synthetic hematoregulatory peptide that shares biological and/or modulatory activities with natural hematopoietic cytokines.
Managing your content with CIMPLE - a content-centric storage interface (2009)

A lot of computer usage involves dealing with files like videos, documents, photos. Unfortunately, for most users sharing (large) files, finding files, synchronizing files between devices and backing up files is far from trivial. To address these issues, we present an alternative for traditional filesystems: CIMPLE. CIMPLE provides a content-centric storage interface with integrated search and sharing capabilities. It also relieves the user of backup and synchronization problems. CIMPLE gives each content item a secure ID and understands content metadata.
What is “powder free”? Characterisation of powder aerosol produced during simulated use of powdered and powder free latex gloves: Table 1 (2001)

Powder free gloves were not entirely free of powder aerosol. Particles from both powdered and powder free gloves are sufficiently fine to penetrate into the thoracic region of the respiratory tract.
Constant-g/sub m/ rail-to-rail CMOS op-amp input stage with overlapped transition regions (1999)

Conventional techniques to achieve a constant-g/sub m/ rail-to-rail complementary N-P differential input stage require complex additional circuitry. In addition, the frequency response and common-mode rejection ratio (CMRR) are degraded. An economical but efficient design technique to overcome these problems is proposed. The proposed technique strategically overlaps the transition regions of the tail currents for the n- and p-pairs to achieve constant overall transconductance. Experimental results demonstrate that g/sub m/ variation can be restricted to within /spl plusmn/4% with improved CMRR and frequency response.