gebhart/patrepeval huggingface dataset:
Tardive dyskinesia (1988)

Tardive dyskinesia (TD) is a syndrome of involuntary movements that develops in predisposed individuals during neuroleptic drug treatment, with an average prevalence of 15%. Neuroleptic (antidopaminergic) drugs are the predominant etiological factor. Although no simple correlation can be established, both dosage and treatment duration seem to be of importance for the development of dyskinesia. It is still uncertain whether some neuroleptics carry a higher risk than others, but it appears that the atypical neuroleptic clozapine, which causes no or minimal dystonia, parkinsonism, or akathisia, also carries no or minimal risk of TD. The pathophysiological mechanisms underlying TD are unclear. The traditional dopamine hypersensitivity theory is no longer viable, whereby new hypotheses have been advanced: TD can be due to the blockade of a subset of striatal dopamine receptors, while parkinsonism is due to the blockade of another such subset, and/or can be due to a reduced GABA turnover in a subgroup of neurons connecting striatum with globus pallidus and substantia nigra. TD is best prevented by a course of neuroleptic medication involving as little antidopamine effect as possible, including minimal doses and shortest possible length of treatment. The main TD treatment principle consists of a gradual dose reduction, possibly over years. It should be added, however, that more recent investigations indicate that traditional antidopaminergic treatment in moderate doses may be safely continued over a long period without an increased risk of TD progression.
Dimensional Analysis and Scale-up of Immiscible Two-Phase Flow Displacement in Fractured Porous Media under Controlled Gravity Drainage (2011)

Oil production from a fractured reservoir, composed of a gas cap and an oil zone, is usually accomplished using surface or submersible pumps. The production method is called controlled gravity drainage (CGD). In the CGD mode of production, the pumps usually operate under a constant withdrawal rate until gas breakthrough, at which time the pumping rate would be influenced by the presence of gas at the production well. In this paper, we describe immiscible displacements in fractured porous media to have a better understanding of the process. Oil−gas CGD displacements were conducted using a laboratory flow apparatus in the fractured glass bead systems. A detailed dimensional analysis was conducted to scale up the experimental results based on the physics of the CGD process and experimental findings. Dimensional analysis of immiscible two-phase flow in porous media allows for quantification of the influences of petrophysical properties of the fractured media and physical properties of test fluids on some important aspects, such as critical pumping rate and recovery factor at gas breakthrough. In this work, an empirical model based on the dimensional groups of the system obtained from the Buckingham π theorem was employed to investigate the gravity drainage process in a fractured porous medium. A model was developed to predict the critical pumping rate, maximum withdrawal rate, distance between the gas−liquid (G−L) interface positions within the matrix and fractures, and recovery factor just before gas breakthrough for fractured porous media undergoing the CGD processes. The model was tested against experimental and field data of oil production under CGD. The results demonstrate that the model gives satisfactory prediction for the oil−gas drainage systems. The procedure outlined in this paper also has potential applications in modeling immiscible displacements.
<i>TRAVAUX DU XVIe COURS INTERNATIONAL DE CRIMINOLOGIE (Proceedings of the XVIth International Course in Criminology)</i> (1969)

"TRAVAUX DU XVIe COURS INTERNATIONAL DE CRIMINOLOGIE (Proceedings of the XVIth International Course in Criminology)." Canadian Journal of Corrections, 11(3), pp. 214–215
Nandrolone decanoate (deca-durabolin) in primary Sjögren's syndrome: a double blind pilot study. (1988)

The efficacy and side-effects of Deca-Durabolin (DD) were tested, in a double blind fashion, in twenty female primary Sjögren's syndrome (1 degree SS) patients. Ten randomly assigned patients received DD (100 mg IM bi-weekly) for six months, and ten others placebo, for the same period. Analysis of the results revealed that the DD-treated patients showed a moderate improvement of subjective xerostomia, a significant decrease of the erythrocyte sedimentation rate (ESR), and an overall improvement of their feeling of well-being, -judged by themselves and the investigator subjectively-, when compared with the placebo group. All the sicca objective parameters (results of Schirmer's I test, slit lamp eye examination after rose bengal staining, stimulated parotid flow rate measurements and labial minor salivary gland histopathology) were not significantly altered in either group. The clinical side-effects were the expected ones, i.e. hirsutism, hoarseness and an increase in libido, more pronounced in the DD-treated group. At the end of the study, one DD-treated patient, developed a diffuse well-differentiated B-lymphocytic lymphoma, which regressed spontaneously three months later.
Expression of human pituitary adenylate cyclase activating polypeptide (PACAP) cDNA in CHO cells and characterization of the products (1992)

cDNA encoding human PACAP precursor was expressed in non-neuroendocrine Chinese hamster ovary cells, CHO-K1, The cells were transfected with expression vector (pTS705) containing the human PACAP cDNA by electroporation. A cell line which produced more than 80 ng/ml of immunoreactive PACAP (ir-PACAP) into the conditioned medium was established. RP-HPLC analysis of culture medium of this established cell line exhibited the presence of two types of PACAP, i.e. PACAP38 and PACAP27. At the same time, it was also revealed that immunoreactive PACAP-related peptide (ir-PRP) was secreted into the cultured medium. The ir-PACAPs were confirmed to ahve biological activities such as induction of cAMP and neurite outgrowth in rat pheochromocytoma PC12h cells.
Characterisation of PGs1, a subunit of a protein complex co-purifying with tubulin polyglutamylase (2003)

Polyglutamylation is a post-translational modification initially discovered on tubulin. It has been implicated in multiple microtubule functions, including neuronal differentiation, axonemal beating and stability of the centrioles, and shown to modulate the interaction between tubulin and microtubule associated proteins. The enzymes catalysing this modification are not yet known. Starting with a partially purified fraction of mouse brain tubulin polyglutamylase, monoclonal antibodies were raised and used to further purify the enzyme by immunoprecipitation. The purified enzyme complex (Mr 360x103) displayed at least three major polypeptides of 32, 50 and 80x103, present in stochiometric amounts. We show that the 32x103 subunit is encoded by the mouse gene GTRGEO22, the mutation of which has recently been implicated in multiple defects in mice, including male sterility. We demonstrate that this subunit, called PGs1, has no catalytic activity on its own, but is implicated in the localisation of the enzyme at major sites of polyglutamylation, i.e. neurones, axonemes and centrioles.
DM Peptide-Editing Function Leads to Immunodominance in CD4 T Cell Responses In Vivo (2005)

DM functions as a peptide editor for MHC class II-bound peptides. We examined the hypothesis that DM peptide editing plays a key role in focusing the in vivo CD4 T cell responses against complex pathogens and protein Ags to only one, or at most a few, immunodominant peptides. Most CD4 T cells elicited in the wild-type BALB/c (H-2d) mice infected with Leishmania major predominantly recognize a single epitope 158-173 within Leishmania homologue of activated receptor for c-kinase (LACK), as is the case when these mice are immunized with rLACK. Using DM-deficient (DM-/-) H-2d mice, we now show that in the absence of DM, the in vivo CD4 T cell responses to rLACK are skewed away from the immunodominant epitopes and are diversified to include two novel epitopes (LACK 33-48 and 261-276). DM-/- B10.BR (H-2k) mice showed similar results. These results constitute the first demonstration of the role of DM peptide editing in sculpting the specificity and immunodominance in in vivo CD4 T cell responses.
Neuroendocrine-specific Expression of the Human Prohormone Convertase 1 Gene (1995)

Prohormone convertases are involved in the tissue-specific endoproteolytic processing of prohormones and neuropeptide precursors within the secretory pathway. In the present study, we have isolated genomic clones comprising the 5'-terminal region of the human prohormone convertase 1 (PC1) gene and identified and characterized the PC1 promoter region. We found multiple transcription start sites located within a 15-base pair region, 205 base pairs upstream of the translation start codon. The promoter region is not G+C-rich and does not contain a canonical TATA box nor a CAAT box. Transient expression assays with a set of human PC1 gene fragments containing progressive 5' deletions demonstrate that the proximal promoter region is capable of directing high levels of neuroendocrine-specific expression of reporter gene constructs. In addition, the proximal promoter region confers both basal and hormone-regulated promoter activity. Site-specific mutagenesis experiments demonstrate that two closely spaced cAMP response elements within the proximal promoter region direct cAMP-mediated hormonal regulation of transcription of the PC1 gene.
Heparinized styrene‐butadiene‐styrene elastomers (1979)

A heparinized high-strength elastomer has been developed which is potentially useful as a nonthrombogenic vascular prosthesis. A surface hydroxylated styrene-butadiene-styrene (SBS) block copolymer with at least 40% extent of reaction after glow-discharge cleaning was coated with a 20% acetylated polyvinyl alcohol/heparin mixture containing glutaraldehyde and magnesium chloride. After curing at 80 degrees C for 100 min, the polyvinyl alcohol, heparin, and hydroxylated SBS were covalently bound to each other by acetal bridges. The effects of the various substrate and coating parameters were optimized to achieve very strong adhesion between the coating layer and the surface hydroxylated SBS. Heparin was not leached from the surface of the new material using 3M saline at pH 7.4 despite a detection limit of 10(-5) micrograms heparin/cm2 min. Prolonged partial thromboplastin times of greater than 1200 sec were observed (control: PTT = 120 sec). Preliminary ex vivo testing using a simple arteriovenous shunt in the leg of a rabbit showed good thromboresistance. The heparinized SBS shunt chamber remained patent for more than two hours without desorption of heparin. It was concluded that surface hydroxylated SBS heparinized by acetal coupling owed its thromboresistance to the heparin covalently bound to the surface and not to a microenvironment of heparin in solution at the blood/material interface.
Bioactive peptides derived from food proteins preventing lifestyle‐related diseases (2000)

Many kinds of bioactive peptides which might prevent lifestyle-related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I-converting enzyme (ACE) having anti-hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8-fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2-7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.
Strategies to Improve the Performance of Carbon/Carbon Capacitors in Salt Aqueous Electrolytes (2015)

International audience
PALATABILITY AND VISUAL ACCEPTANCE OF DARK, NORMAL AND PALE COLORED PORCINE M. LONGISSIMUS (1976)

ABSTRACT Pork loins from carcasses weighing 68–75 kg were compared for quality characteristics. A total of 120 loins, with equal numbers of pale and watery, normal and dark colored loins, were evaluated. Pale chops had a significantly higher cooking loss than normal or dark colored chops. The consumer panel scored the pale chops significantly lower in organoleptic acceptability than normal or dark chops. The trained panel gave a similar rating for the organoleptic evaluation. When the consumer panel selected pork chops from a retail display case, the normal colored chops received the highest rating and the pale, watery chops the lowest. The pale chops were the most unstable and developed a greenish‐gray cast after 2–3 days' storage. The normal colored chops had significantly more intramuscular fat and less protein than either pale or dark chops.
A novel polarization diversity antenna for WLAN applications (2002)

Due to the advantage of mobility, there are many applications in wireless local area networks (WLAN) in the 2.4 GHz ISM band. For these applications, multipath effects are the common reception problems in dynamic, complex electromagnetic environments. In order to reduce signal fading caused by multipath effects, diversity techniques are usually required for the antenna system at the receiving site. For this reason, a modified printed strip monopole antenna having a polarization diversity with a hybrid feed system is proposed in this paper. From experimental results, it is shown that the impedance bandwidth for the proposed antenna can reach over 17%, and the antenna length is only 17 mm (/spl sim/0.14 /spl lambda//sub 0/, where /spl lambda//sub 0/ is the free-space wavelength of the center operating frequency). Owing to its compactness in antenna length, the proposed antenna can be integrated into a restricted area of 30 mm/spl times/50 mm as a part of a WLAN PCMCIA card.
Video image stitching based on moving object detection and motion prediction compensation (2010)

This paper proposed a novel image stitching algorithm based on fast moving object detection and motion prediction compensation, which can avoid ghosting caused by the moving target. We estimates the global motion vector through extracting and matching SIFT features. Based on the global motion estimation, calculate the relative difference image of the overlapping region in the pair of registered images. Then the gray-scale projection curve of the difference image is analyzed to judge whether moving object exists or not. If a moving object appears, we dedicate to updating the moving object with relevant background information collected from the next frame or the one currently reserved in buffer. The experiments show good performance for stitching video sequences in the presence of moving object.
CX3C Chemokine Fractalkine in Pulmonary Arterial Hypertension (2002)

Perivascular infiltrates composed of macrophages and lymphocytes have been described in lung biopsies of patients displaying pulmonary arterial hypertension (PAH), suggesting that circulating inflammatory cells can be recruited in affected vessels. CX(3)C chemokine fractalkine is produced by endothelial cells and promotes leukocyte recruitment, but unlike other chemokines, it can capture leukocytes rapidly and firmly in an integrin-independent manner under high blood flow. We therefore hypothesized that fractalkine may contribute to pulmonary inflammatory cell recruitment in PAH. Expression and function of the fractalkine receptor (CX(3)CR1) were studied by use of triple-color flow cytometry on circulating T-lymphocyte subpopulations in freshly isolated peripheral blood mononuclear cells from control subjects and patients with PAH. Plasma-soluble fractalkine concentrations were measured by enzyme-linked immunosorbent assay. Finally, fractalkine mRNA and protein expression were analyzed in lung samples by reverse transcriptase-polymerase chain reaction or in situ hybridization and immunohistochemistry, respectively. In patients with PAH, CX(3)CR1 expression and function are upregulated in circulating T-lymphocytes, mostly of the CD4+ subset, and plasma soluble fractalkine concentrations are elevated, as compared with control subjects. Fractalkine mRNA and protein product are expressed in pulmonary artery endothelial cells. We conclude that inflammatory mechanisms involving chemokine fractalkine and its receptor CX(3)CR1 may have a role in the natural history of PAH.
Over‐expression of a transcription factor regulating ABA‐responsive gene expression confers multiple stress tolerance (2004)

Unfavourable environmental conditions, such as drought, freezing and high salinity, are major limiting factors of plant productivity. Plants perceive and respond adaptively to such 'abiotic stress' conditions, and the adaptive process is controlled mainly by the phytohormone, abscisic acid (ABA). The hormone, whose level increases under various stress conditions, functions as a signal to trigger adaptive responses that include changes in gene expression patterns. We have recently reported transcription factors that regulate the ABA-responsive gene expression. As ABA mediates adaptation to several common abiotic stresses, we investigated whether the transcription factors are involved in various stress responses. Here, we report that over-expression of ABF3, one of the factors, confers tolerance to chilling, freezing, high temperature and oxidative stress in addition to drought. Our results indicate that ABF3 is involved in multiple stress responses, and that it may be a useful genetic resource for the engineering of plant stress tolerance.
Susceptibility of Heat-Moisture-Treated Starches to Pancreatic .ALPHA.-Amylase, and the Formation of Resistant Starch by Heat-Moisture Treatment. (1993)

バレイショ澱粉に120℃,60分の湿熱処理を1回および2回行った試料(1と皿),およびハイアミロース・コーンスターチに134℃,70分の処理を2回および4回行った試料(III とIV)の4種の湿熱澱粉試料について,ブタ膵臓α-アミラーゼによる糊化澱粉の分解限度を求め,また抵抗性澱粉(RS)の生成量を測定した.α-アミラーゼによる分解限度は未処理バレイショ澱粉の分解率を100とした相対値で示すと,I～Nについてそれぞれ82,78,48,46で,湿熱処理の強度にしたがって順次減少した.RS生成量は試料I～IV について,それぞれ原澱粉量の1.4,2.4,44.0,53,7%で,処理の強度にしたがって増加した.α-アミラーゼによる分解率とRS生成量はほぼ逆比例の関係にあった.III,IV に対するRS定量値は従来の報告に比してかなり高く,従来の定量法では用いた酵素によって本来のRSのかなりの部分が分解されていることを示した.よってRSの研究には膵臓α-アミラーゼのみを用いるべきであることが主張された.さらに湿熱処理澱粉について示差走査熱量測定を行い,吸熱温度の上昇または降下と吸熱量の減少を認めた.また顕微鏡による観察で,湿熱処理による澱粉粒の崩壊と融合が認められた. DSC分析をしていただいた東京農工大学農学部高橋幸資助教授に深謝する.
Study of dielectric material property impact on insertion loss for advanced packaging solutions (2015)

This paper evaluates the impact of dielectric loss tangent property on electrical insertion loss performance for both conventional and coreless packaging designs up-to 100Gbps datarate. Coreless package with metal grid array (MGA) second level interconnect (SLI) that yields minimal impedance discontinuities was observed gaining more than 50% insertion loss improvements i.e. ~20% higher compared to conventional design with dielectric loss tangent improved from 0.03 to 0.006.
Impact of Si/Al implantation on the forming voltage and pre-forming conduction modes in HfO<inf>2</inf> based OxRAM cells (2016)

In this work, we study the impact of Si and Al implantation on the current conduction mechanisms and operation of 1T-1R TiN/HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Ti/TiN based ReRAM devices. The pre-forming current and forming voltage evolution clearly reveal different trends as a function of the implanted dose and species. We link our results to the microscopic structure of the material using a first principles approach.
Neural Network-Hardware Co-design for Scalable RRAM-based BNN Accelerators (2018)

Recently, RRAM-based Binary Neural Network (BNN) hardware has been gaining interests as it requires 1-bit sense-amp only and eliminates the need for high-resolution ADC and DAC. However, RRAM-based BNN hardware still requires high-resolution ADC for partial sum calculation to implement large-scale neural network using multiple memory arrays. We propose a neural network-hardware co-design approach to split input to fit each split network on a RRAM array so that the reconstructed BNNs calculate 1-bit output neuron in each array. As a result, ADC can be completely eliminated from the design even for large-scale neural network. Simulation results show that the proposed network reconstruction and retraining recovers the inference accuracy of the original BNN. The accuracy loss of the proposed scheme in the CIFAR-10 testcase was less than 1.1% compared to the original network. The code for training and running proposed BNN models is available at: https://github.com/YulhwaKim/RRAMScalable_BNN.
No. 4 ESS--Evolution of a Digital Switching System (1979)

The No. 4 Electronic Switching System, a high capacity, toll and tandem system based on digital time division switching was first placed in service in Chicago on January 17, 1976. It has provided improved system operation and new service features at reduced cost in comparison to the existing electromechanical systems. The flexibility of system architecture has permitted the evolution of the No. 4 Electronic Switching System. Since cutover of the first system, the introduction of improved hardware and software has made possible additional savings in equipment as well as reducing power and space requirements by approximately 60 percent. The introduction of the 700 ns stores has increased the computing power of the processor by 30 percent, Which has made possible the addition of new revenue producing features without reducing switching capacity. With the new features, No. 4 ESS is now being used in the North American domestic toll and tandem as well as international switching networks. In addition, the move toward centralization of maintenance and administration of the system will further reduce maintenance costs. The overall performance of the 21 in-service systems has been excellent.
Characterization of PKD Protein-Positive Exosome-Like Vesicles (2009)

Proteins associated with autosomal dominant and autosomal recessive polycystic kidney disease (polycystin-1, polycystin-2, and fibrocystin) localize to various subcellular compartments, but their functional site is thought to be on primary cilia. PC1+ vesicles surround cilia in Pkhd1(del2/del2) mice, which led us to analyze these structures in detail. We subfractionated urinary exosome-like vesicles (ELVs) and isolated a subpopulation abundant in polycystin-1, fibrocystin (in their cleaved forms), and polycystin-2. This removed Tamm-Horsfall protein, the major contaminant, and subfractionated ELVs into at least three different populations, demarcated by the presence of aquaporin-2, polycystin-1, and podocin. Proteomic analysis of PKD ELVs identified 552 proteins (232 not yet in urinary proteomic databases), many of which have been implicated in signaling, including the molecule Smoothened. We also detected two other protein products of genes involved in cystic disease: Cystin, the product of the mouse cpk locus, and ADP-ribosylation factor-like 6, the product of the human Bardet-Biedl syndrome gene (BBS3). Our proteomic analysis confirmed that cleavage of polycystin-1 and fibrocystin occurs in vivo, in manners consistent with cleavage at the GPS site in polycystin-1 and the proprotein convertase site in fibrocystin. In vitro, these PKD ELVs preferentially interacted with primary cilia of kidney and biliary epithelial cells in a rapid and highly specific manner. These data suggest that PKD proteins are shed in membrane particles in the urine, and these particles interact with primary cilia.
High current gain (&lt;2000) and reduced common-emitter offset voltage of GaN/InGaN double heterojunction bipolar transistors (2004)

In this paper, we report on the significantly improved common-emitter I-V characteristics of GaN/InGaN DHBT with this regrown p-InGaN base layer.
OCDE. (1991). . Barcelona: Paidós / Madrid: Escuela y calidad de la enseñanza. (1992)

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