gebhart/patrepeval huggingface dataset:
Intermittent oxaliplatin (oxali) administration and time-to-treatment-failure (TTF) in metastatic colorectal cancer (mCRC): Final results of the phase III CONcePT trial (2008)

4010 Background: About 60% of mCRC patients (pts) discontinue oxali prior to disease progression (PD), largely driven by cumulative neurotoxicity (NT). CONcePT (Combined Oxaliplatin Neurotoxicity Prevention Trial) was initiated to test if an intermittent oxali (IO) schedule of FOLFOX/bevacizumab (BV) allows pts to remain on therapy longer compared to a conventional oxali (CO) “treat-to- failure” approach. To explore the impact of IV calcium/magnesium (CaMg: Ca-gluconate 1g, Mg-sulfate 1g, pre/post oxali) on NT, pts were randomized in a 2x2 factorial design (IO vs. CO) x (CaMg vs. placebo [PL] - double-blinded). Methods: Eligibility criteria included measurable disease, PS 0–1, no neuropathy. In CO arms, pts received mFOLFOX7 (oxali 85mg/m2, LV 200mg/m2, 5FU 2,400mg/m2 x 46h) plus BV (5mg/kg) q2wks. In the IO arms, pts alternated every 8 cycles with and without oxali. After 140 pts, a protocol amendment eliminated the CaMg vs. PL randomization and 40 subsequent pts all received CaMg. TTF (primary endpoint) was calculated as time from randomization to treatment discontinuation for any reason, including PD, death, toxicity, investigator or patient preference. Results: The study was terminated 6/07 by the IDMC based on unadjudicated tumor response data suggesting lower RR for CaMg compared with PL. In the 2x2 phase of the trial (n=139 treated pts), median age was 64y (30–88), 53% PS 0, 55% male, 80% colon, 22% prior adjuvant chemo, 12% prior radiation. Aes were the main cause of treatment failure (35% of pts, IO 28% vs. CO 43%); 22% of failures were due to PD (IO 23% vs CO 21%). Only 1 pt in the IO arm required early reintroduction of oxali. A 2-factor Cox regression model of TTF revealed a statistically significant effect for IO vs CO (median TTF 25 vs 18 wks, p=0.0025, HR=0.58, 95% CI 0.41- 0.83), but not for CaMg vs PL (p=0.1179, HR=1.32, 95% CI 0.93–1.86). Conclusions: Despite early termination, CONcePT met its primary endpoint, demonstrating that IO results in increased time on therapy compared to CO. This strategy is particularly useful in extending time on first-line therapy for oxali/BV combinations. Final results on RR, PFS, and safety (including NT) will be presented. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration sanofi-aventis Genentech, Roche, sanofi-aventis Genentech, sanofi-aventis
Verifying and Mining Frequent Patterns from Large Windows over Data Streams (2008)

Mining frequent itemsets from data streams has proved to be very difficult because of computational complexity and the need for real-time response. In this paper, we introduce a novel verification algorithm which we then use to improve the performance of monitoring and mining tasks for association rules. Thus, we propose a frequent itemset mining method for sliding windows, which is faster than the state-of-the-art methods - in fact, its running time that is nearly constant with respect to the window size entails the mining of much larger windows than it was possible before. The performance of other frequent itemset mining methods (including those on static data) can be improved likewise, by replacing their counting methods (e.g., those using hash trees) by our verification algorithm.
The Metabolic Syndrome and Antioxidant Concentrations (2003)

Oxidative stress may play a role in the pathophysiology of diabetes and cardiovascular disease, but little is known about antioxidant status among individuals with the metabolic syndrome who are at high risk for developing these conditions. Using data from the Third National Health and Nutrition Examination Survey (1988-1994), we compared circulating concentrations of vitamins A, C, and E; retinyl esters; five carotenoids; and selenium in 8,808 U.S. adults aged > or = 20 years with and without the metabolic syndrome. After adjusting for age, sex, race or ethnicity, education, smoking status, cotinine concentration, physical activity, fruit and vegetable intake, and vitamin or mineral use, participants with the metabolic syndrome had significantly lower concentrations of retinyl esters, vitamin C, and carotenoids, except lycopene. With additional adjustment for serum lipid concentrations, vitamin E concentrations were significantly lower in participants with the metabolic syndrome than those without the syndrome. Retinol concentrations were similar between the two groups. After excluding participants with diabetes, the results were very similar. Consumption of fruits and vegetables was also lower among people with the metabolic syndrome. Adults with the metabolic syndrome have suboptimal concentrations of several antioxidants, which may partially explain their increased risk for diabetes and cardiovascular disease.
Uniforms for Collegiate Female Golfers: Cause for Dissatisfaction and Role Conflict? (1999)

Female collegiate athletes (N = 71 ) from Big Ten Conference golf teams were surveyed about their satisfaction with team uniforms and the factors influencing satisfaction. Players rated their satisfaction with team uniforms as neutral. Both quantitative and qualitative responses indicated positive relationships between having well-fitting, aesthetically attractive uniforms and uniform satisfaction. Men's clothing, worn by a majority of the female golfers, was often bulky and ill-fitting, associated with greater uniform dissatisfaction. Although wearing a recognizable apparel brand name product gave players satisfaction, the actual product produced by these manufacturers did not. Contrary to our hypothesis, role conflict experienced by the athlete did not significantly affect uniform satisfaction. Implications for sport clothing manufacturers are discussed.
On the Sintering of the TiN-Ni Binary Powder Compacts (1978)

Sintering characteristics of TiN-Ni mixed powder compacts were studied by heating them in a gas atmosphere of nitrogen, hydrogen or argon, or in a vacuum.Shrinkage during sintering was disturbed in all of the gas atmospheres, whereas in a vacuum it was promoted remarkably accompanying the occurrence of the liquid phase and denitridation. The solubility of nitrogen in the nickel phase was very small and the composition of the titanium nitride phase equilibrated with the nickel phase was slightly lower than stoichiometric, ie., TiN0.99.The solid solubilities of TiN1−x in the nickel phase at various temperatures were determined by X-ray diffraction, and the maximum solubility of 5.2 wt% was found at 1350°C.
Three-dimensional structure-activity relationships and receptor mapping of N1-substituents of quinolone antibacterials (1991)

Quantitative structure-activity relationships for quinolone antibacterials have been previously examined and a steric parameter L for the N1-substituents found to be important in QSAR equations. But some compounds for which previous QSAR equations could not predict the activity have appeared recently. In this study, conformations of a variety of N1-substituents of quinolone antibacterials were analyzed by a molecular modeling method. An active conformation of each of the compounds was estimated with information of the energy profile calculated by molecular orbital methods and of its biological activity. A model of a receptor corresponding to the N1-substituents was constructed by superposing van der Waals volumes of active conformer of highly active compounds. As a result of these conformational analyses and receptor mapping, it is proposed that there are two different optimum volumes for increasing the activity of quinolone antibacterials and two unfavorable regions for reducing the activity. It is suggested that the steric parameter L which appeared in previous QSAR equations corresponds to one of the optimum volumes of the proposed receptor model. With this receptor model, a relation between structure and activity of the compounds, including those mispredicted compounds in previous QSAR equations is able to be rationalized qualitatively and elegantly. We believe that this receptor model is useful for a prediction of the activity of compounds not yet synthesized as well as for designing new quinolone antibacterials.
An FPGA implementation of Walsh-Hadamard transforms for signal processing (2002)

This paper describes two approaches suitable for an FPGA implementation of Walsh-Hadamard transforms. These transforms are important in many signal processing applications including speech compression, filtering and coding. Two novel architectures for the fast Hadamard transforms using both systolic architecture and distributed arithmetic techniques are presented. The first approach uses the Baugh-Wooley multiplication algorithm for a systolic architecture implementation. The second approach is based on both distributed arithmetic ROM and accumulator structure, and a sparse matrix factorisation technique. Implementations of the algorithms on a Xilinx FPGA board are described. Distributed arithmetic approach exhibits better performances when compared with the systolic architecture approach.
Polarization‐sensitive scanned fiber confocal microscope (1996)

We describe a polarization-sensitive fiber optic based confocal microscope. Polarization maintaining single mode fibers are used to illuminate a specimen with linearly polarized light. The orientation of the incident linearly polarized light is continuously variable using a Se´narmont polarization rotator. A polarization-sensitive light detector enables the microscope to record the intensity and polarization orientation of the reflected light. The microscope can thus function as a conventional confocal microscope as well as detect rotations of the polarization orientation of the incident light by a birefringent specimen. Lateral scanning of the microscope focal volume is achieved by moving the fiber tip in a reciprocal layout. Confocal operation of the system is demonstrated both theoretically and experimentally. The theoretical and measured responses of the microscope to a dielectric mirror, glass slide, quarter wave plate, linear polarizer, and calcite crystal are considered. Images of a birefringent specimen are presented.
EMA-an Intelligent Employment Agent (2002)

The author presents an Intelligent Employment Agent, EMA, available through the Internet. EMA provides national employment information about career opportunities, fresh graduates, scholarships, employment boards, unemployed workers, and performs matching between available applicants and available jobs. EMA sends mail to users whenever an interesting employment information appears, e.g. whenever a specific profile is available or needed, or whenever an interesting Web site changes. In the first year, the system was visited around 100000 times. It presented 100000 vacant job positions in Slovenia, and was one of the most often visited Internet systems in the country.
WIREBONDER ASSEMBLY OF HINGELESS 90° OUT-OF-PLANE MICROSTRUCTURES (2006)

A novel design and analysis for the assembly of 90 out-ofplane microstructures using a standard microelectronics wirebonder is presented. The microstructures can be assembled by a single point actuation and use a selectively compliant spring system that converts an in-plane motion to an out-of-plane rotation. The single point actuation can be provided by a standard microelectronics wirebonder. A wirebonder is a common piece of equipment for microelectronics packaging and therefore the assembly method described here introduces a practical and economical approach. The microstructure designs were fabricated using either PolyMUMPs or a prototyping process developed at Simon Fraser University that uses SU-8 as a structural layer. The designs were modeled using the Finite Element Analysis (FEA) software ANSYS, and tested for positional repeatability and reliability verifying the proof of concept.
Herpes simplex virus glycoprotein K is known to influence fusion of infected cells, yet is not on the cell surface (1995)

Syncytial mutants of herpes simplex virus (HSV) cause extensive fusion of cultured cells, whereas wild-type HSV primarily causes cell rounding and aggregation. A large fraction of syncytial viruses contain mutations in the UL53 gene, which encodes glycoprotein K (gK). Previously, we demonstrated that wild-type and syncytial forms of gK are expressed at similar levels and possess identical electrophoretic mobilities. Using immunofluorescence, we show that gK is not transported to the surfaces of cells infected with either wild-type or syncytial HSV. Instead, gK accumulates in the perinuclear and nuclear membranes of cells. This finding is in contrast to the behavior of all other HSV glycoproteins described to date, which reach the cell surface. When gK was expressed in the absence of other HSV proteins, using a recombinant adenovirus vector, a similar perinuclear and nuclear pattern was observed. In addition, gK remained sensitive to endoglycosidase H, consistent with the hypothesis that gK does not reach the Golgi apparatus and is retained in the endoplasmic reticulum and nuclear envelope. Therefore, although gK mutations promote fusion between the surface membranes of HSV-infected cells, the glycoprotein does not reach the plasma membrane and, thus, must influence fusion indirectly.
Tenth Meeting of the Association for Symbolic Logic (1948)

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Lactobacillus delbrueckii subsp. lactis (2020)

Lactobacillusdelbrueckii subsp. lactis Lactobacillusdelbrueckii subsp. lactis (lac’tis. L. gen. n. lactis, of milk). L. delbrueckii subsp. lactis includes strains previously designated as L. lactis and L. leichmannii; L. delbrueckii subsp. lactis ferments glucose to D(−)-lactic acid and also metabolises sucrose, fructose and mannose, maltose and trehalose [60]. Thegenome size is 1.87 Mbp andthe mol% G+C content of DNAis 49.9. Isolatedfrom milk, cheese, compressedyeasts and grain mash. Thetypestrainis L 110 T =ATCC 12315 T =CCUG 31454 T =CIP 101028 T =DSM 20072 T = JCM 1248 T =LMG 7942 T =NBRC 102622 T =NRRL B-4525 T. Genome sequence accession number: AZDE00000000. 16S rRNA gene accession number: AY050173.
Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy (2009)

Highly localized reflectance measurements can be used to directly quantify scatter changes in tissues. We present a microsampling approach that is used to raster scan tumors to extract parameters believed to be related to the tissue ultrastructure. A confocal reflectance imager was developed to examine scatter changes across pathologically distinct regions within tumor tissues. Tissue sections from two murine tumors, AsPC-1 pancreas tumor and the Mat-LyLu Dunning prostate tumor, were imaged. After imaging, histopathology-guided region-of-interest studies of the images allowed analysis of the variations in scattering resulting from differences in tissue ultra-structure. On average, the median scatter power of tumor cells with high proliferation index (HPI) was about 26% less compared to tumor cells with low proliferation index (LPI). Necrosis exhibited the lowest scatter power signature across all the tissue types considered, with about 55% lower median scatter power than LPI tumor cells. Additionally, the level and maturity of the tumor's fibroplastic response was found to influence the scatter signal. This approach to scatter visualization of tissue ultrastructure in situ could provide a unique tool for guiding surgical resection, but this kind of interpretation into what the signal means relative to the pathology is required before proceeding to clinical studies.
Fine-Tuning the Class Yard (2009)

This article discusses how the combination of hardware and software can help railroads in improving capacity and efficiency. It first describes how computer-aided yard dispatching systems can be used to control field devices and route trains, providing capabilities such as individual switch control and alignment, route stacking, remote blocking, event recording, and switch diagnostics. The article then discusses how railroads such as BNSF, CSX, and the Belt Railway Company (BRC) are using specific CAD products in their classification yards. The article also includes a sidebar describing how simulation modeling can be used as a tool in classification yard and terminal design. It provides an illustration of how simulation software was used at the Port of Long Beach for reconfiguring trackage in order to increase on-dock rail traffic.
Objectively Measured Boar Sperm Motility Parameters Correlate With the Outcomes of On‐Farm Inseminations: Results of Two Fertility Trials (1997)

Two fertility trials were undertaken to evaluate the relationship between boar semen quality and fertility (conception rate and litter size) after on-farm artificial insemination (AI). Trial 1 included 98 ejaculates from 27 boars, and trial 2 included 72 ejaculates from 26 boars. The semen quality was measured by computer-assisted semen analysis (CASA) using the Hobson Sperm Tracker. Boar semen was diluted in a standard extender (Beltsville Thawing Solution, BTS), dispensed into 75 ml allquots each containing 1.5 x 10(9) spermatozoa and dispatched to farms by overnight mail for use by their normal AI procedures. Randomly selected 75 ml aliquots of semen from each boar were also sent to the institute of Zoology for CASA measurement. Prior to CASA analysis, the spermatozoa were recovered from the BTS using Percoll gradients, resuspended in trisbuffered saline media containing 40 mM Ca++, and incubated at 39 degrees C. Parameters of sperm motion were measured after 0, 2, 4, and 6 hours of incubation. Various multiple regression models based on measured motion parameters could account for up to 24% of the variation in litter size. Using logistic regression, highly significant (P < 0.0001) models explaining conception rate in terms of sperm motion were derived for trial 2 only. The change in sperm velocity during the first 2 hours of incubation and the magnitude of the velocity parameters after 2 hours were identified as the most consistent indicators of fertility. Other attributes of sperm quality, i.e., frequency of spontaneous acrosome reactions (AR) and ARs induced by ionophore A23187 or solubilized pig zona pellucida, were also examined. When the "within-trial" median litter size was used as a way of allocating ejaculates to "high" or "low" litter-size groups, higher litter size was associated with lower frequency of both spontaneous and induced AR. These results demonstrate that fertility information can be derived from the CASA analysis of boar semen provided it is combined with a period of incubation in capacitating conditions.
Quantum Cryptography Based on Two Mixed States (1996)

Although it is known that any two nonorthogonal pure states can constitute a secure quantum cryptosystem, the generalization of this scheme to the use of two mixed states is not trivial. It is shown here that even if a condition corresponding to the nonorthogonality in the pure-state case is satisfied, the mixed-state cryptosystem is still vulnerable to attack by an eavesdropper. A necessary and sufficient condition for the secure communication is derived. It states that the two mixed states must be connected by a rotation operator with a nonorthogonal angle.
Wireless sensing applications in the mining and minerals industry (2009)

This paper discusses and outlines applications of wireless sensing technology in the mining and minerals industry to provide enhanced assistance to mining machines. Three major applications can be performed by radar systems, such as surface profiling, positioning and collision avoidance. Radar sensors offer significant advantages compared to laser and ultrasonic in tough environments like rain, dust, fog and snow. The information received from the sensors can be used to increase the automation level and to advance the safety in the mine plus furthermore increase the turnover of mining companies. Underground communication systems and machine diagnostics are also discussed in this paper. Several applications were determined as highly feasible and are now completed respectively in the implementation stage. The authors are giving an insight into the experimental results, the implementation and an outlook of further use for this technology.
Fast Iterative Subspace Algorithms for Airborne STAP Radar (2006)

Space-time adaptive processing (STAP) is a crucial technique for the new generation airborne radar for Doppler spread compensation caused by the platform motion. We here propose to apply range cell snapshots-based recursive algorithms in order to reduce the computational complexity of the conventional STAP algorithms and to deal with a possible nonhomogeneity of the data samples. Subspace tracking algorithms as PAST, PASTd, OPAST, and more recently the fast approximate power iteration (FAPI) algorithm, which are time-based recursive algorithms initially introduced in spectral analysis, array processing, are good candidates. In this paper, we more precisely investigate the performance of FAPI for interference suppression in STAP radar. Extensive simulations demonstrate the outperformance of FAPI algorithm over other subspace trackers of similar computational complexity. We demonstrate also its effectiveness using measured data from the multichannel radar measurements (MCARM) program.
Targeting the Minor Groove of DNA:  Crystal Structures of Two Complexes between Furan Derivatives of Berenil and the DNA Dodecamer d(CGCGAATTCGCG)<sub>2</sub> (1996)

Crystal structures are reported of complexes of two novel furan derivatives of berenil with alkyl benzamidine groups bound to the DNA sequence d(CGCGAATTCGCG)2. They have both been determined to 2.2 A resolution and refined to R factors of 16.9% and 18.6%. In both structures the alkyl substituents, cyclopropyl and isopropyl, are found to be orientated away from the floor of the minor groove. The drugs are located in the minor groove by two strong amidinium hydrogen bonds, to the O2 of the thymines situated at the 5' and 3' ends of the AT-rich region. The isopropyl-substituted derivative has a tight hydrogen-bonded water network in the minor groove at one amidine site, which alters the orientation of the isopropyl substituent. This compound has superior DNA-binding properties and activity against Pneumocystis carinii and Cryptosporidium parvum infections in vivo compared to the cyclopropyl derivative, which in turn is superior to the parent furan compound. We suggest that the nature and extent of the interactions of these compounds in the DNA minor groove play an important role in these activities, possibly in conjunction with a DNA-binding protein. The overall effect of these alkyl benzamidine substitutions is to increase the binding of the drugs to the minor groove.