gebhart/patrepeval huggingface dataset:
Molecular cloning of a cDNA for rat hepatic glutaminase. Sequence similarity to kidney-type glutaminase. (1990)

Mammalian liver possesses a unique isozyme of phosphate-activated glutaminase which plays an important role in the regulation of glutamine catabolism. Antibodies to hepatic glutaminase were used to screen a lambda gt11 rat liver cDNA library. One cDNA to hepatic glutaminase was identified. Changes in the relative abundance of hepatic glutaminase mRNA were determined by hybridization to this cDNA. The mRNA is found only in liver; it is not present prior to birth but its abundance increases dramatically at birth. The abundance of the mRNA is increased approximately 4-fold in diabetes. The sequence of the cDNA was compared to that recently published for kidney (brain)-type glutaminase (Banner, C., Hwang, J.-J., Shapiro, R.A., Wenthold, R.J., Nakatani, Y., Lampel, K.A., Thomas, J.W., Huie, D., and Curthoys, N.P. (1988) Mol. Brain Res. 3, 247-254). When the predicted amino acid sequences were compared a region of 123 amino acids with greater than 80% identity was found. The presence of scattered amino acid substitutions within stretches of identical amino acids suggests that the glutaminase isozymes are encoded by separate genes. This is the first demonstration of any similarity between the two glutaminases at the molecular level.
cw LASER ACTION ON 24 VISIBLE WAVELENGTHS IN Se II (1970)

cw laser action has been observed at 24 wavelengths in the visible spectrum of Se II in a He–Se discharge. The wavelengths range from 4604 to 6535 Å. A power output of 30 mW was measured on six lines oscillating simultaneously. We obtained as many as 13 wavelengths lasing at the same time in a cavity with broad-band high-reflectivity mirrors.
[Natriuretic peptides as novel growth factor of growth plate cartilage]. (2002)

Recently evidence has accumulated that natriuretic peptides (NPs) are important regulator of endochondral ossification. Three peptides, ANP, BNP and CNP constitute the NPs family. cGMP production through two particulate guanylate cyclases is involved in their signal transduction. ANP and BNP have high affinity for GC-A and CNP for GC-B. Third receptor, called clearance receptor (NPR-C) is involved in NPs clearance. Mice that overexpress BNP or CNP and mice deficient in NPR-C exhibited marked body elongation, whereas mice deficient in CNP showed dwarfism. CNP enhanced longitudinal growth in organ-cultured long bones, and stimulated the differentiation of osteoblast and cartilage lineage cells. Dwarfism was observed in mice deficient in cGMP-dependent protein kinase II which lies downstream to cGMP. Since three genetically body-elongated mice were proven to have mutations in NPR-C, it is possible that CNP/GC-B/cGK II pathway is related to some clinical disorders. CNP is also expected to have therapeutic application to diseases with dwarfism.
Production and Characterization of Improved Liposomes Containing Radiographic Contrast Media (1990)

The authors have investigated liposomes prepared by the reverse-phase evaporation method (REVs) and a modification of this technique that employs a microemulsifier (MREVs), for the delivery of radiographic contrast media (RCM) to the liver and spleen. The modification entailed substituting a Microfluidizer (Microfluidics Inc., Newton, MA) for the sonication step of the REV technique. The MREV procedure is amenable to large-scale production and continuous-flow operation and yields products with high RCM encapsulation. Efficiently entrapped are ionic, high-osmolar diatrizoate (24.38 +/- 2.62% versus 8.35 +/- 0.55%; MREV versus REV), and nonionic, low osmolar Iotrolan (Schering AG, Berlin, FRG) (24.84 +/- 2.13% versus 7.25 +/- 1.19%) RCM with iodine-to-lipid ratio of 1.5:1. The MREV procedure, therefore, has practical advantages over the REV method. High liver and spleen uptakes of Iotrolan-containing vesicles were noted in normal rats. The diatrizoate MREVs lost their contents on contact with serum, resulting in urinary excretion of this agent. Computed tomography values of splenic and hepatic sections, 1 hour after intravenous injection of Iotrolan MREV (500 mgI/kg), are 0.78, and 0.08 Hounsfield Units (HU)/mgI/kg, respectively (versus 0.01, and 0.006 HU/mgI/kg for free Iotrolan).
Complementary filter design on the Special Euclidean group SE(3) (2007)

This paper considers the problem of obtaining high quality pose estimation (position and orientation) from a combination of low cost sensors, such as an inertial measurement unit and vision sensor. A non-linear complementary filter is proposed that evolves on the Special Euclidean Group SE(3). Exponential stability of the filter is proved. Simulation results are presented to illustrate simplicity and demonstrate the performance of the proposed approach. Experimental results reinforce the convergence of the filter.
Seismic structure of the Juan de Fuca Ridge: Ocean bottom seismometer results from the Median Valley (1976)

An axial valley at the northern end of the Juan de Fuca ridge was the site where two new ocean bottom seismometers were tested in a seismic refraction experiment. Detailed underway geophysical data, seismic reflection profiles, and heat flow measurements were already available for area. By combining the refraction results from surface and bottom shots, the axial valley was found to be filled with at least 1.7 km of largely unconsolidated sediments that were deposited in about 0.3 m.y. VP is estimated for the sediments at 1.7 km/s; a P to SV converted wave allows estimation of VS as 0.51 km/s and Poisson's ratio as 0.450. More distant shots show that the crust in the area (all less than 2.5 m.y. in age) is matured and has velocities similar to those of the typical oceanic section given by Peterson et al. (1974). The upper mantle has a normal 8.3-km/s velocity across the ridge, but laterally localized low-velocity mantle must exist beneath the axial valley. This localized low velocity must be even lower than the anisotropically lower velocity commonly observed parallel to the crest in ridge flank studies.
Recent Developments in Metabolism That Impinge on Research into the Nature and Treatment of Diabetes Mellitus (1992)

It has been established that adenosine, its agonists, or antagonists can cause dramatic changes in insulin sensitivity in isolated soleus muscle and, moreover, can modify changes in sensitivity caused by pathophysiological conditions. Addition of adenosine deaminase to the incubation medium, which is known to lower the concentration of adenosine, increases the sensitivity of glycolysis to insulin. Addition of an adenosine-receptor agonist decreases sensitivity by about 10-fold, whereas addition of an adenosine-receptor antagonist increases sensitivity by about 10-fold. The latter totally removes the resistance of glucose utilization to insulin in the isolated soleus muscle obtained from either the genetically obese rat or from the rat fed a high sucrose diet. These findings strongly support the view that changes in insulin sensitivity in muscle can be brought about either by acute changes in the local concentration of adenosine or in the affinity or number of receptors for adenosine in muscle. However, in many of the conditions investigated, in which insulin sensitivity in muscle is changed, there was no correlation between the change in the adenosine content of the muscle and altered insulin sensitivity. It has also been shown that prostaglandin E1 can increase dramatically the sensitivity of glycolysis to insulin and that this is a specific effect of prostaglandins of the E series. It is not produced by prostacyclins, thromboxanes, or leukotrienes. It is unclear if there is a relationship between the effects of adenosine and prostaglandins. Chronic elevation of catecholamines may increase the sensitivity of glucose utilization to insulin and also increase the rate of thermogenesis by substrate cycling.(ABSTRACT TRUNCATED AT 250 WORDS)
Beneficiation of Green River Oil Shale by Pelletization (1981)

A procedure is described for the beneficiation of Green River oil shale, based on the wettability contrast between the organic kerogen and its inorganic minerals. It entails the milling of the shale in a mixture of water and a liquid hydrocarbon binding agent followed by the separation of kerogen-enriched pellets and the rejection of an aqueous dispersion of hydrophilic mineral particles. A portion of the calcite and dolomite is rendered oleophilic and inseparable from the hydrocarbon-swollen kerogen pellets. This is brought about by the adsorption of oil soluble carboxylic constituents contained in the bitumens. Certain shale samples were upgraded from an initial kerogen content of 15 percent to a kerogen content in excess of 80 percent.
Field-Effect-Transistor Sensor Based on Enzyme-Functionalized Polypyrrole Nanotubes for Glucose Detection (2008)

We describe the detection of glucose based on a liquid-ion gated field-effect transistor configuration in which enzyme-functionalized polypyrrole nanotubes are employed as the conductive channel. First of all, carboxylated polypyrrole nanotubes (CPNTs) were successfully fabricated by the chemical polymerization of an intrinsically functionalized monomer (pyrrole-3-carboxylic acid, P3CA) without degradation in major physical properties. The CPNTs possessed not only well-defined functional groups but also electrical properties comparable to nonsubstituted polypyrrole. Importantly, the carboxylic acid functional group can be utilized for various chemical and biological functionalizations. A liquid-ion gated FET sensor was readily constructed on the basis of the chemical functionality of CPNTs. In the first stage, the CPNTs were immobilized onto a microelectrode substrate via covalent linkages. It was noteworthy that the covalent immobilization allowed high-quality contact between the nanotubes and the microelectrodes in the liquid phase. The second stage involved the covalent binding of glucose oxidase (GOx) enzyme to the nanotubes. The covalent functionalization generally provides excellent enzymatic activity and thermal stability. The fabricated FET sensor provided real-time response (an increase in source-drain current) and high sensitivity toward the various concentrations (0.5-20 mM) of glucose. The enzymatic reaction product, hydrogen peroxide, played pivotal roles in modulating the charge transport property of CPNTs.
The Influence of the Foreign-Born of the Northwest in the Election of 1860 (1932)

Journal Article The Influence of the Foreign-Born of the Northwest in the Election of 1860 Get access Donnal V. Smith Donnal V. Smith Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 19, Issue 2, September 1932, Pages 192–204, https://doi.org/10.2307/1891452 Published: 01 September 1932
A novel codec for thin client computing (2002)

In this paper, we describe thin client compression (TCC), a novel codec for screendumps and sequences of such images that exploits both local and global redundancy as well as interframe redundancy. Our method extends textual image compression to non-bilevel images, and uses three piecewise-constant models to separately code bilevel marks, non-bilevel marks, and the residue. It also speeds up pattern matching and substitution by exploiting the absence of noise in synthetic images, and shares its codebook across images. Our method compresses a series of test images 2.6 to 8.2 times better than state-of-the-art methods. Its speed is adequate for interactive logins, and it achieves the best end-to-end latency over low bandwidth connections.
Effect of Using Ethanol as the Oxygen Source on the Growth and Dielectric Behavior of Atomic Layer Deposited Hafnium Oxide (2014)

Use of common atomic layer deposition (ALD) oxygen sources such as oxygen, ozone or water often causes uncontrolled oxidation of the silicon surface by diffusion through the growing HfO 2 film during the ALD process. This results in thick interfacial layer (IL) that is detrimental to future transistor scaling if further thinning of the IL is desired. In order to minimize the uncontrolled oxidation at the interface, we explored the use of ethanol as the ALD oxygen source in the ALD HfO 2 process. The effect of using ethanol on the growth, composition and electrical behavior of ALD HfO 2 films was studied and compared against films prepared using water based ALD process. Ethanol showed good reactivity with the hafnium precursor tetrakis(diethylamino)hafnium and displayed typical ALD growth behavior of linear film growth within a wide ALD process temperature window (200-280 °C). The ethanol based ALD process exhibited HfO 2 growth rate of 0.05 nm/cycle which was less than 0.15 nm/cycle obtained when water was used as the ALD oxygen source. X-ray photoelectron spectroscopy (XPS) showed the deposition of stoichiometric HfO 2 with trace amount of carbon in the film. SiO 2 interfacial layer was not observed in as-deposited samples, whereas annealed samples showed SiO 2 XPS features. Films prepared using the ethanol based ALD process showed comparable dielectric performance to that of water based ALD process films and displayed well behaved C-V and I-V curves with as-deposited (ethanol) HfO 2 samples showing the lowest leakage current density of 5 x 10 -8 A/cm 2 at 1 V gate bias.
Multilabeling Biomolecules at a Single Site. 1. Synthesis and Characterization of a Dendritic Label for Electrochemiluminescence Assays (2003)

Ultrasensitive bioanalytical assays are of great value for early detection of human diseases and pathogens. The sensitivities of immunoassays and DNA probing can be enhanced by multilabeling the biorecognition partner used for affinity-based assays. However, the bioreactivity of biomolecules is affected by a high degree of multilabeling at multiple functional sites. It is proposed that dendritic scaffoldings be used to link multiple signal-generating units to a single site with potentially minimum impact on the bioaffinity. A prototype label, a zeroth-generation dendron, bearing three [Ru(bpy)(3)](2+) units for electrochemiluminescence (ECL) assays was synthesized and characterized preliminarily by spectroscopic, electrochemical, and ECL methods. No evidence of interaction between the neighboring [Ru(bpy)(3)](2+) units in the label molecule was found from these characterizations. Both the photoluminescence and ECL of the prototype label have features very similar to those of mononuclear [Ru(bpy)(3)](2+) compounds. Labeling a model protein with a triad of [Ru(bpy)(3)](2+) at one NH(2) position was demonstrated. The results reported here provide support to applying the proposed multilabeling strategy to affinity-based bioanalytical assays.
Effect of 4-Acryloxyethyltrimellitic Acid in a Self-etching Primer on Bonding to Ground Dentin (1996)

To develop a self-etching primer for ground dentin, 4-acryloxyethyltrimellitic acid (4-AET) was newly synthesized, and the effect of concentrations varying from 0 (control) to 56.5 wt% 4-AET in the water/ HEMA primer on bonding to the dentin was investigated. Bond strength to the dentin was significantly affected by the inclusion of 4-AET in the primer which also contained N,N-di(hydroxyethyl)-p-toluidine (DEPT) when compared with the control (0% 4-AET) (p < 0.01). The optimum 4-AET-concentration and the mean bond strength (SD) were found to be 6.5 wt%: 24.2 (3.6 MPa, 37.4 wt%: 25.3 (4.4) MPa, 47.2 wt%: 26.9 (11.6) MPa and 54.4 wt%: 29.7 (12.9) MPa. The role of DEPT in the 4-AET/HEMA primer was assessed, and the optimum DEPT-concentration was found to be 0.154 and 0.307 mol%. Regarding the hypothetical bonding mechanism to dentin, it was thought that the ionized 4-AET in water/HEMA would penetrate into dentin substrates, and DEPT as an accelerator in situ would facilitate photo-polymerization at the dentin-resin interface, and result in increased bond strength to ground dentin.
Driving information logger with in-vehicle communication for autonomous vehicle research (2018)

In this paper, we describe in detail the driving information logging used in developing an autonomous vehicle. The recorded vehicle information is used to identify the cause of problems in the system or undesired operations. Driving information logging can be used in many areas such as analysis of problems in the study of autonomous driving system and analysis of accident risk.
Three-Phase Phase-Locked Loop Control of a New Generation Power Converter (2006)

This paper describes the development of a new generation of power converter, used to power telecommunications equipment. A telecommunications converter must comply with the psophometric noise standard CCIF-1951 and the IEC1000-3-2 harmonic standard. While the IEC1000-3-2 standard is easily met with active power factor correction techniques, a high degree of effort is usually required to meet with the psophometric standard. Therefore, a control methodology utilising a three-phase phase-locked loop is introduced as a method of complying with the psophometric standard under distorted mains conditions. Simulations show that combining this with a novel feedback controller, results in an improved load step response over using a traditional proportional integral type controller
Crosswell seismic applications for improved reservoir understanding (2015)

Abstract Crosswell seismic (CS) technology provides a high-resolution image of the subsurface between two nearby wells. Crosswell seismic data can reach frequencies greater than 1000 Hz, which makes the technology applicable to many reservoir-development challenges in hydrocarbon exploration and production studies that require high resolution. Applications of crosswell seismic data range from structural and stratigraphic interpretation to reservoir monitoring and enhanced oil recovery (EOR). When integrated with rock physics, crosswell seismic data can be used in reservoir-characterization studies, which potentially could be used for enhancing the resolution of rock properties derived from 3D surface-seismic data to that of crosswell resolution. In addition, velocity models obtained from crosswell seismic data can be used to better predict event locations in microseismic data processing.
Measuring Concept Similarities in Multimedia Ontologies: Analysis and Evaluations (2007)

The recent development of large-scale multimedia concept ontologies has provided a new momentum for research in the semantic analysis of multimedia repositories. Different methods for generic concept detection have been extensively studied, but the question of how to exploit the structure of a multimedia ontology and existing inter-concept relations has not received similar attention. In this paper, we present a clustering-based method for modeling semantic concepts on low-level feature spaces and study the evaluation of the quality of such models with entropy-based methods. We cover a variety of methods for assessing the similarity of different concepts in a multimedia ontology. We study three ontologies and apply the proposed techniques in experiments involving the visual and semantic similarities, manual annotation of video, and concept detection. The results show that modeling inter-concept relations can provide a promising resource for many different application areas in semantic multimedia processing.
A study on the background and clustering seismicity in the Taiwan region by using point process models (2005)

This paper investigates the shallow seismicity occurring in the Taiwan region during the 20th century using a stochastic declustering method that has been developed on the basis of the theory of the epidemic‐type aftershock sequence model. It provides a probability based tool to objectively separate the space‐time occurrences of earthquakes into a background and a clustering component. On the basis of the background and clustering seismicity rates, we discuss the correlation between the distribution of the cluster ratio and the regional seismotectonic structures. Specifically, we find that the areas of the highest clustering ratio correspond to the major strike‐slip fault traces in and around Taiwan. Additionally, in the Taiwan inland region, during the period 1960–1990, the outputs for the stochastically declustered catalogue show a clear quiescence in background seismicity preceding the recovery of activation and the occurrences of the 1999 Chi‐Chi earthquake of M L 7.3, while the other active regions show stationary background activity. This could be interpreted as an effect of the aseismic slip in the Chi‐Chi rupture fault, whereby the inland region around the Chi‐Chi source becomes a stress shadow.
Synthesis and Characterization of PAMAM Dendrimer-Based Multifunctional Nanodevices for Targeting α <sub>v</sub> β <sub>3</sub> Integrins (2007)

We have synthesized a stable and clinically relevant nanodevice (cRGD-BT-ND; ND for short) that exhibits superior binding to the biologic target alphavbeta3 integrins, when either compared to the same free cRGD peptide or to the biotinylated nanodevice without covalently attached peptides (BT-ND). Selective targeting of alphavbeta3 integrins was achieved by coupling cyclic cRGD peptides to the nanodevice (ND) surface, while biotin groups (BT) were used for amplified detection of bound cRGD-BT-ND by anti-biotin antibody or avidin linked to horseradish peroxidase after binding. The synthesis involved the following steps: the amino-terminated ethylenediamine core generation 5 poly(amidoamine) (PAMAM_E5.NH2) dendrimer was first partially acetylated and then biotinylated, and residual primary amine termini were converted to succinamic acid groups (SAH), some of which finally were conjugated with cRGD peptide residues through the amino group of the lysine side chain. The starting material and all derivatives were extensively characterized by polyacrylamide gel electrophoresis (PAGE), size exclusion chromatography (SEC), potentiometric acid-base titration, MALDI-TOF, and NMR. Cytotoxicity of all dendrimer derivatives was examined in B16F10 melanoma cell cultures using the XTT colorimetric assay for cellular viability. Binding of nanodevices to the biological target was determined using plates coated with human alphavbeta3 integrin and alphavbeta3 receptor expressing human dermal microvascular endothelial cells (HDMECs). The PAMAM_E5.(NHAc)72(NHBT)8(NHSAH)35(NHSA-cR GD)4 nanodevice is nontoxic within physiologic concentration ranges and specifically binds to the alphavbeta3 integrins, apparently much stronger than the cyclic cRGD peptide itself.
Kinetics of ozone and nitric oxides in dielectric barrier discharges in O<sub>2</sub>/NO<sub><i>x</i></sub>and N<sub>2</sub>/O<sub>2</sub>/NO<sub><i>x</i></sub>mixtures (2001)

Concentrations of NO, NO2, NO3, N2O5, and O3 were measured by classical absorption spectroscopy in dielectric barrier discharges in flowing O2/NOx and N2/O2/NOx mixtures. The results of measurements in different parts of the discharge chamber and in its exhaust are compared to a numerical zero-dimensional kinetic model and good agreement is found. The experimentally found upper limit of the NOx concentration allowing ozone production is confirmed by the kinetic calculations for both gas mixtures. The rotational temperature of different nitrogen bands was measured by high-resolution emission spectroscopy. The results are explained on the basis of a simplified model and related to the gas temperature in the microdischarge channel and the surrounding gas.