gebhart/patrepeval huggingface dataset:
Cartas al director. Fiebre persistente y monoartritis psoriásica (2002)

The aim of this study was to identify the effects of connective tissue manipulation (CTM) in primary dysmenorrhea (PD) in a randomized, placebo-controlled design. Thirty-eight nulliparous women with PD were randomly allocated into 3 groups: CTM (n = 13), placebo therapeutic ultrasound (US) (n = 13), and control (n = 12). The primary outcome measure was the maximum and mean menstrual pain intensity at the last menstrual period on the visual analogue scale (VAS). Secondary outcome measures were menstrual symptom frequency and distress score, the number of analgesic/anti-inflammatory drugs used during the last menstrual period, and perception of improvement in dysmenorrhea severity via interventions. The chi-square test and analysis of variance were used to determine within-group and between-group differences. Statistical significance level was determined as p < 0.05. Compared with the placebo US and control groups, it was observed that menstrual pain (VAS mean and VAS maximum), menstrual symptom frequency, and distress level decreased more after treatment (T2) and the 3-month follow-up (T3) in de CTM group (p < 0.001, p = 0.001, p = 0.014, p = 0.015, respectively). There was no difference between the groups in terms of analgesic/anti-inflammatory drugs use (p > 0.05). The rate of individuals reporting perceived improvement at the end of intervention period was higher in the CTM group than in the placebo-US and control groups (p < 0.001). In the 3rd month follow-up, there was no difference between groups in the perception of improvement (p > 0.05). CTM is superior to placebo intervention and control in improving menstrual pain and other menstrual symptoms in PD in the short-term. On the other hand, when the application is terminated, this superiority seems to disappear during the follow-up period.
REVIEWS (1967)

Journal Article REVIEWS Get access Die Engelvorstellungen ber Ephram dem Syrer By WINFRID CRAMER Pp xx+197 (Orientalia Christiana Analecta, 173) Rome Pontificium Institutum Orentalium Studiorum, 1965 L 2,500 A E GOODMAN A E GOODMAN Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume XVIII, Issue 2, October 1967, Pages 497–498, https://doi.org/10.1093/jts/XVIII.2.497 Published: 01 October 1967
Bile acid composition regulates the manganese transporter Slc30a10 in intestine (2020)

Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules that carry out physicochemical and signaling functions. A major site of BA action is the terminal ileum, where enterocytes actively reuptake BAs and express high levels of BA-sensitive nuclear receptors. BA pool size and composition are affected by changes in metabolic health, and vice versa. One of several factors that differentiate BAs is the presence of a hydroxyl group on C12 of the steroid ring. 12α-Hydroxylated BAs (12HBAs) are altered in multiple disease settings, but the consequences of 12HBA abundance are incompletely understood. We employed mouse primary ileum organoids to investigate the transcriptional effects of varying 12HBA abundance in BA pools. We identified <i>Slc30a10</i> as one of the top genes differentially induced by BA pools with varying 12HBA abundance. SLC30A10 is a manganese efflux transporter critical for whole-body manganese excretion. We found that BA pools, especially those low in 12HBAs, induce cellular manganese efflux and that <i>Slc30a10</i> induction by BA pools is driven primarily by lithocholic acid signaling via the vitamin D receptor. Administration of lithocholic acid or a vitamin D receptor agonist resulted in increased <i>Slc30a10</i> expression in mouse ileum epithelia. These data demonstrate a previously unknown role for BAs in intestinal control of manganese homeostasis.
The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture (2001)

The gamma-secretase cleavage is the last step in the generation of the beta-amyloid peptide (Abeta) from the amyloid precursor protein (APP). The Abeta precipitates in the amyloid plaques in the brain of Alzheimer's disease patients. The fate of the intracellular APP carboxy-terminal stub generated together with Abeta has been, in contrast, only poorly documented. The analogies between the processing of APP and other transmembrane proteins like SREBP and Notch suggests that this intracellular fragment could have important signalling functions. We demonstrate here that APP-C59 is rapidly degraded (half-life approximately 5 min) when overexpressed in baby hamster kidney cells or primary cultures of neurones by a mechanism that is not inhibited by endosomal/lysosomal or proteasome inhibitors. Furthermore, APP-C59 binds to the DNA binding protein Fe65, although this does not increase the half-life of APP-C59. Finally, we demonstrate that a fraction of APP-C59 becomes redistributed to the nuclear detergent-insoluble pellet, in which the transcription factor SP1 is also present. Overall our results reinforce the analogy between Notch and APP processing, and suggest that the APP intracellular domain, like the Notch intracellular domain, could have a role in signalling events from the plasma membrane to the nucleus.
CspB and CspL, thermostable cold‐shock proteins from <i>Thermotoga maritima</i> (2003)

TmCspB and TmCspL (i) are able to perform essential functions of E. coli Csps in vitro and in vivo, 50-65 degrees C below the temperature optimum of T. maritima and (ii) can anti-terminate transcription by T. maritima RNA polymerase at 55 degrees C, the lower limit of temperature range for growth of T. maritima. We propose that the observed properties of TmCsps are physiologically relevant and that TmCsps are important for adaptation of T. maritima to physiologically low temperatures.
Laser processing of chemically derived dichroic filters (1993)

Optical interference filters were fabricated using multilayer stacks derived from sol-gel SiO<sub>2</sub> and SiO<sub>2</sub>-TiO<sub>2</sub> coatings. Laser processing was then used to modify the spectral properties (color) of local regions of these stacks. Changes in color were analyzed with respect to changes in the individual film thicknesses and refractive indices. Design considerations and some basic limitations of laser firing for tuning interference filter colors are also discussed.
Structural and Electrochemical Characterization of Li<sub>2</sub>MnSiO<sub>4</sub> Cathode Material (2009)

The candidate cathode material Li2MnSiO4 for lithium-ion cells was synthesized by an all-acetate precursor sol/gel method under a reducing atmosphere at 600, 700, and 800 °C. The material prepared at 700 °C was a pure phase and had the structural order of Li3PO4 orthorhombic (S.G. Pmn21) phase. The temperature dependence of the molar magnetic susceptibility of Li2MnSiO4 was found to be consistent with an antiferromagnetic material with a Néel temperature of 12 K. The calculated effective moment confirmed that the observed magnetic behavior involves Mn2+ ions in a high spin configuration in tetrahedral sites. Scanning electron microscopy of Li2MnSiO4 showed large aggregates (10 to 50 μm) composed of nanosized particles (100−200 nm). The as-prepared material was almost electrochemically inactive despite the presence of 15 wt % carbon additive. The material was treated by carbon coating using cellulose carbon source precursor and particle size reduction using high-energy ball milling. In coin-cell tests, the carbon-coated and ball-milled materials yielded charge capacities of 190 and 172 mAh/g, respectively, under a current density of 10 mA/g. At present, the cationic mixing between Li+ and Mn2+ ions in their mutual crystallographic sites is the main impediment to the achievement of the full theoretical capacity of Li2MnSiO4 (333 mAh/g).
Silica Sulfuric Acid/ NaNO2 as a Novel Heterogeneous System for the Nitration of Phenols under Mild Conditions (2002)

Nitrophenols can be obtained in moderate to high yields via nitrosationoxidation of phenols with silica sulfuric acid, NaNO2 and wet SiO2 at room temperature. In situ generation of HNO2 and a radical cation mechanism via the nitrous acid catalyzed (NAC) pathway appear to be applicable to phenol nitration using these reagents.
Unsupervised iterative manifold alignment via local feature histograms (2014)

We propose a new unsupervised algorithm for the automatic alignment of two manifolds of different datasets with possibly different dimensionalities. Alignment is performed automatically without any assumptions on the correspondences between the two manifolds. The proposed algorithm automatically establishes an initial set of sparse correspondences between the two datasets by matching their underlying manifold structures. Local feature histograms are extracted at each point of the manifolds and matched using a robust algorithm to find the initial correspondences. Based on these sparse correspondences, an embedding space is estimated where the distance between the two manifolds is minimized while maximally retaining the original structure of the manifolds. The problem is formulated as a generalized eigenvalue problem and solved efficiently. Dense correspondences are then established between the two manifolds and the process is iteratively implemented until the two manifolds are correctly aligned consequently revealing their joint structure. We demonstrate the effectiveness of our algorithm on aligning protein structures, facial images of different subjects under pose variations and RGB and Depth data from Kinect. Comparison with an state-of-the-art algorithm shows the superiority of the proposed manifold alignment algorithm in terms of accuracy and computational time.
A wavelength diversity technique for smoothing of speckle (1974)

Theoretical and experimental results are given for the
wavelength dependence of speckle, thus establishing a method for the reduction of speckle noise in holographic microscopy with the use of multitoned illumination and a panchromatic viewing system. A model is presented for a partially diffuse phase type of object and the statistical behavior of t he speckle produced in the image of this
object is studied. A calculation is made for the spectral autocorrelation function which gives a wavelength spacing required to decouple the speckle patterns produced by two tones, this spacing being found to be inversely proportional to the standard deviation of the heights of the scatterers on the object. A criteria is defined for the degradation of an image due to speckle and the resultant improvement is found to depend on the square root of the
number of independent tones used.

The wavelength dependence of speckle is verified in a
series of experiments where we illuminate the object by both laser and bandlimited light. We first demonstrate the averaging of speckle in the image of a pap smear when we use four tones of an argon laser (5145, 4965, 4880 and 4765 A). We then show that the image of a rough object is speckly even for bandwidths up to 5A; and then we demonstrate the smoothing of speckle when both a scotch
tape diffuser and a section of an optic nerve is illuminated by six equally spaced bandlimited tones scanning 1,500A.

Thus, in this study, we demonstrate the feasibility of
eliminating objective speckle in holographic microscopy using a multimonochromatic source and also provide a theoretical basis for studying the properties of rough surfaces by studying the wavelength diversity of the speckle produced by them.
Virus safety of beta-propiolactone treated plasma preparations. Clinical experiences. (1987)

Sterilization of human plasma with beta-propiolactone and UV-irradiation (cold sterilization) has been shown to be effective for a number of common pathogenic viruses. We have published data on the hepatitis safety of cold sterilized factor IX concentrates (PPSB) in healthy volunteers. This study has now been extended to include 6 virgin hemophilia B patients, who have been treated with cold sterilized PPSB for a period of up to 5 years. None of these volunteers or patients exhibited clinical symptoms or laboratory data indicating the transmission of either viral hepatitis (B or NANB) or acquired immunodeficiency syndrome (AIDS). Hyperimmunoglobulin (HIg) preparations from cold sterilized plasma, offering protection against hepatitis B and NANB are also safe regarding HTLV-III virus transmission, even though these preparations may contain HTLV-III antibody titers up to 1:1000.
Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner (2011)

Higher magnesium levels prevented BVSMC calcification, inhibited expression of osteogenic proteins, apoptosis and further progression of already established calcification. Thus, magnesium is influencing molecular processes associated with VC and may have the potential to play a role for VC also in clinical situations.
Automated DNA fragment collection by capillary array gel electrophoresis in search of differentially expressed genes (2000)

An automatic DNA fragment collector using capillary array gel electrophoresis has been developed. A sheath flow technique is used for not only detection but also collection of DNA fragments. In a sheath flow cell, the DNA fragments separated by 16 capillaries flow independently into corresponding sampling capillaries. The fraction collector consists of 16 sampling trays and each sampling tray is set beneath each end of the sampling capillaries to collect the flow-through DNA fragments. Certain DNA fragments are automatically sorted by controlling the movement of the sampling trays according to the signals from the system. The collector experimentally separated two mixtures of polymerase chain reaction (PCR) products: one prepared by using eight different sizes (base lengths from 161 to 562) of DNAs; and the other prepared by a differential display (DD) method with cDNA fragments. Collected DNA fragments are amplified by PCR and measured by electrophoresis. DNA fragments with base length differences of one (base lengths 363 and 364) were successfully separated. A separated DNA fragment from the DD sample was also successfully sequenced. In addition, differentially expressed DNA fragments were automatically sorted by comparative analysis, in which two similar cDNA fragment groups, labeled by two different fluorophores, respectively, were analyzed in the same gel-filled capillary. These results show that the automatic DNA fragment collector is useful for gene hunting in research fields such as drug discovery and DNA diagnostics.
An idea based on sequential pattern mining and deep learning for text summarization (2019)

Abstract One of the Natural Language Processing (NLP) studies that has been widely researched is automatic text summarization. There are a lot of techniques and methods that are proposed for text summarization. However, not much attention has been given on the coherence and cohesion in text. The aim of this study is to present an idea to combine Sequential Pattern Mining (SPM) and Deep Learning (DL) for better text summarization process and result. In text summarization, it is important to produce understable and readable summary, and SPM as text representation extracting algorithm is capable to maintain the meaning of text by giving attention of the order of words appearance. Whereas DL is a popular and powerful machine learning technique widely used recently in various data mining studies. This study uses descriptive research methodology that collects all of the facts and information which are related to SPM and DL for text summarization, where NLP as the body of knowledge, SPM and DL as the method, and text summarization as the domain problem that need to be solved. The findings of the study are presented as a logical design and mapping of current text representation that can be implemented to further improve automatic text summarization results, in particular, to improve its coherence and cohesion.
DHT Based Collaborative Multimedia Streaming and Caching Service (2005)

Multimedia streaming and video on demand (VoD) services are among those hottest applications over the Internet. Traditional client/server pattern is stumbled due to the lack of scalability and limitation of service capacity. Peer-to-peer paradigm has been introduced to solve these issues. The key idea is that peers not only receive multimedia stream but also serve multimedia data to others. In this paper, we present a novel scheme that builds a multimedia streaming and caching service on a distributed hash table (DHT) based overlay. We adopt DHT to establish a decentralized caching service. The location information of cached segments is distributed among different peers and the information about segments from the same video is organized into an application-level multicast group. We also propose a cache replace algorithm on each peer. In our simulation, our design achieves good scalability with a low service reject rate. Besides, good load balance is also achieved as well as desired quality-of-service.
Stochastic learning automata-based time series analysis for network anomaly detection (2008)

The main drawback of traditional intrusion detection systems makes anomaly detection systems an active research area. In this paper we introduce a novel network-based anomaly detection approach using stochastic learning automata. The paper main objective is to construct a network-based statistical anomaly detection system capable of classifying the ensemble network broadcast traffic as normal or abnormal. For this purpose the approach constructs a learning automaton from time series data of purified network broadcast traffic in learning process. Time series data of observed network broadcast traffic are compared by the normal model and any deviation from it is marked as abnormal. This approach is novel in that apply stochastic learning automaton with a special reinforcement scheme to the problem of network anomaly detection and presents an online high precision network-based anomaly detection system using broadcast traffic time series data.
Structural Analysis of TRAS1, a Novel Family of Telomeric Repeat-Associated Retrotransposons in the Silkworm, <i>Bombyx mori</i> (1995)

We characterized TRAS1, a retrotransposable element which was inserted into the telomeric repetitive sequence (CCTAA)n of the silkworm, Bombyx mori. The complete sequence of TRAS1, a stretch of 7.8 kb with a poly(A) tract at the 3' end, was determined. No long terminal repeat (LTR) was found at the termini of the element. TRAS1 contains gag- and pol-like open reading frames (ORFs) which are similar to those of non-LTR retrotransposons. The two ORFs overlap but are one nucleotide out of frame (+1 frameshift). Most of the approximately 250 copies of TRAS1 elements in the genome were highly conserved in the structure. Chromosomal in situ hybridization showed that TRAS1 elements are clustered at the telomeres of Bombyx chromosomes. A phylogenetic analysis using the amino acid sequence of the reverse transcriptase domain within the pol-like ORF revealed that TRAS1 falls into one lineage with R1, which is a family of non-LTR retrotransposons inserted into the same site within the 28S ribosomal DNA unit in most insects. TRAS1 may have been derived from R1 and changed the target specificity so that TRAS1 inserts into the telomeric repetitive sequence (CCTAA)n. Southern hybridization and Bal 31 exonuclease analyses showed that TRAS1 elements are clustered proximal to the terminal long tract of (CCTAA)n. TRAS1 is a novel family of non-LTR retrotransposons which are inserted into the telomeric repetitive sequences as target sites.
Orientation microscopy with fast EBSD (2010)

Automated backscatter Kikuchi diffraction in the SEM is about to become a tool for process and quality control. Mandatory requirements for these applications are a high speed and provisions to enable re-examination of the results at any time. Means and motivation for high speed electron backscattering diffraction are discussed. Separate acquisition and store of pattern sequences in an unprocessed data format, followed by offline calculation of the grain orientations, has many advantages over online orientation microscopy. With actually >1000 acquired patterns per second it is significantly faster than conventional electron backscattering diffraction. The data can be examined again using the original backscatter Kikuchi sequences, and the presence of a priori unknown phases can be checked for. Online pattern solving, as a dual task, is optional.
Development and application of new positively charged filters for recovery of bacteriophages from water (1991)

Electronegative and electropositive filters were compared for the recovery of indigenous bacteriophages from water samples, using the VIRADEL technique. Fiber glass and diatomaceous earth filters displayed low adsorption and recovery, but an important increase of the adsorption percentage was observed when the filters were treated with cationic polymers (about 99% adsorption). A new methodology of virus elution was developed in this study, consisting of the slow passage of the eluent through the filter, thus increasing the contact time between eluent and virus adsorbed on the filters. The use of this technique allows a maximum recovery of 71.2% compared with 46.7% phage recovery obtained by the standard elution procedure. High percentages (over 83%) of phage adsorption were obtained with different filters from 1-liter aliquots of the samples, except for Virosorb 1-MDS filters (between 1.6 and 32% phage adsorption). Phage recovery by using the slow passing of the eluent depended on the filter type, with recovery ranging between 1.6% for Virosorb 1-MDS filters treated with polyethyleneimine and 103.2% for diatomaceous earth filters treated with 0.1% Nalco.
Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System (2017)

Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited capacity of CNS regeneration. The causes underlying this limited regenerative potential are multifactorial, but one critical aspect is neuroinflammation. Although classically considered as harmful, it is now becoming increasingly clear that inflammation can also promote regeneration, if the appropriate context is provided. Here, we review the current knowledge on how acute inflammation is intertwined with axonal regeneration, an important component of CNS repair. After optic nerve or spinal cord injury, inflammatory stimulation and/or modification greatly improve the regenerative outcome in rodents. Moreover, the hypothesis of a beneficial role of inflammation is further supported by evidence from adult zebrafish, which possess the remarkable capability to repair CNS lesions and even restore functionality. Lastly, we shed light on the impact of aging processes on the regenerative capacity in the CNS of mammals and zebrafish. As aging not only affects the CNS, but also the immune system, the regeneration potential is expected to further decline in aged individuals, an element that should definitely be considered in the search for novel therapeutic strategies.