gebhart/patrepeval huggingface dataset:
Forecasting acute hypotensive episodes in intensive care patients based on a peripheral arterial blood pressure waveform (2009)

We entered the 10th Annual PhysioNet/Computers in Cardiology Challenge to predict which intensive care patients would experience an acute hypotensive episode (AHE) using physiologic data prior to the occurrence of the AHE. An AHE was defined through mean arterial blood pressure (ABP). We took a pragmatic approach to the Challenge. We explored six basic indices derived from ABP data near the forecast window including mean ABP and diastolic ABP. We evaluated the predictive ability of each index on the provided training dataset and employed basic classification on the testing dataset. All indices performed well on the training dataset and achieved a perfect score for Event 1 of the Challenge and scores from 32/40 to 37/40 for Event 2. However, our best official score was 36/40 for Event 2. These results stress the importance of continuous ABP monitoring in intensive care patients and indicate that sophisticated data analysis was not necessary to win the Challenge.
Hypertrichosis cubiti, a case report and literature review (2015)

Hypertrichosis cubiti is an uncommon congenital hypertrichosis with links to genetic syndromes, both autosomal dominant and recessive, with variable penetrance and expressivity. It may also present in sporadic cases with no phenotypic abnormalities or family history.
Pediatric Idiopathic Pulmonary Hemosiderosis Diagnosed by Sputum Analysis: Plain Radiography and Computed Tomography Findings (2003)

Although IPH is a rare condition, the diagnosis of IPH should be considered, among others, in a patient with hemoptysis and bilateral infiltration in the chest X-ray. This may prevent antibiotic misuse and risk of death due to severe hemorrhage.
An Analogy Between the Cell and a Factory: A Teaching Technique (1968)

Often in a study of the cell and its cellular processes such as photosynthesis, respiration, assimilation, and growth, biology students find it difficult to acquire an adequate idea of how these living processes interact. Synthesis of these separate processes into an organized whole is even more difficult to comprehend. This paper describes an analogy between a factory and the cell that has been found effective as a classroom discussion technique to more clearly illustrate what the cell must do to maintain itself and to divide.
NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in <i>Mycobacterium smegmatis</i> (1998)

Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in Mycobacterium smegmatis. Mutations that reduce NADH dehydrogenase activity (Ndh; type II) cause multiple phenotypes, including (i) coresistance to INH and a related drug, ethionamide; (ii) thermosensitive lethality; and (iii) auxotrophy. These phenotypes are corrected by expression of one of two enzymes: NADH dehydrogenase and the NADH-dependent malate dehydrogenase of the M. tuberculosis complex. The genetic data presented here indicate that defects in NADH oxidation cause all of the mutant traits and that an increase in the NADH/NAD+ ratio confers INH resistance.
<i>p</i> -type quantum well infrared photodetectors covering wide spectrum (2002)

Using a set of p-type GaAs/AlGaAs quantum well infrared photodetectors, a wide spectral coverage is demonstrated. Photoresponses at wavelengths as short as 1.4 µm and as long as 15 µm are shown. The shortest wavelength device with a high Al fraction (95%) peaks at 1.9 µm and covers a range of 1.4 to 3 µm.
Immunization with the Light Chain and the V<sub>L</sub> Domain of the Isologous Myeloma Protein 315 Inhibits Growth of Mouse Plasmacytoma MOPC315 (1980)

Prior immunization of BALB/c mice with free light chains from myeloma protein 315 (L315) and its variable domain (VL315) inhibited the growth of subcutaneously injected MOPC315 tumour cells. The growth suppression observed after immunization with L315 was equivalent to that which resulted from immunization with the complete M315. VL315 and non-polymerized L315 did not elicit specific antibodies. Polymerized L315 induced both suppression of MOPC315 growth and antibodies specific for free L315; however, these antibodies did not react with the complete M315, nor were they absorbed by MOPC315 tumour cells. The data indicate that the suppression of tumour growth was mediated by specifically sensitized cells acting in the absence of antibodies against M315 or L315. Immunization with the variable domain of the heavy chain from M315 (VH315) had no effect on the growth of MOPC315. The M315 fragments and subunits that induced growth suppression were thus identical with those capable of inducing T helper cells in BALB/c mice.
High performance of planar double gate MOSFETs with thin backgate dielectrics (2002)

Planar double gate CMOS devices with thin silicon channels and electrically separate polysilicon top and bottom gates are fabricated. NFETs with L/sub design/=175 nm and 1.3 mA//spl mu/m and PFETs with L/sub design/=125 nm and 400 /spl mu/A//spl mu/m are achieved at V/sub dd/=1.2 V. To our knowledge, this is the largest current yet achieved in double gate NMOS devices. Electrical results show a high quality backgate dielectric, improvement of SCE using the backgate, and the importance of reducing external resistance in short channel devices.
Methods for the Recovery of Salmonella spp. from Carboxymethylcellulose Gum, Gum Ghatti, and Gelatin (1998)

Foods analyzed for Salmonella spp. by the procedure in the U.S. Food and Drug Administration's Bacteriological Analytical Manual are preenriched at a 1:9 test portion/broth ratio. Various thickening agents preenriched at this ratio become viscous and nonpipettable after 24 h incubation at 35 degrees C. The effects of 3 factors (presence of inorganic salts, adjustment of pH, and presence of enzymes) on the viscosity of the test portion/preenrichment mixtures of various thickening agents during incubation were determined. Reduction of the viscosities of these thickening agents was accomplished as follows: carboxymethylcellulose gum, addition of cellulase to a final concentration of 0.10% in lactose broth preenrichment and incubation with no pH adjustment; gum ghatti, addition of NaCl to a final concentration of 0.10% in lactose broth preerichment and adjustment of the pH to 6.5; and gelatin, addition of papain to a final concentration of 0.10% in lactose broth preenrichment and adjustment of the pH to 6.8. With these modified preenrichments, one Salmonella spp. cell/25 g (representing an approximate most probable number value of 0.04 cell/g) was generally recovered from the thickening agents.
Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. (1996)

Mesothelial cells, the progenitor cell of the asbestos-induced tumor mesothelioma, are particularly sensitive to the toxic effects of asbestos, although the molecular mechanisms by which asbestos induces injury in mesothelial cells are not known. We asked whether asbestos induced apoptosis in mesothelial cells and whether reactive oxygen species were important. Pleural mesothelial cells (rabbit or human) were exposed to asbestos (crocidolite, amosite, or chrysotile) or control particles at moderate doses (1-10 microg/cm2) over 24 h and evaluated for oligonucleosomal DNA fragmentation, loss of membrane phospholipid asymmetry, and nuclear condensation. Asbestos fibers, not control particles, induced apoptosis in mesothelial cells by all assays and induction of apoptosis was dose dependent for all types of asbestos, with crocidolite (5 microg/cm2) inducing 15.0+/-1.1% (mean+/-SE; n = 12) apoptosis versus control particles < 4%. Apoptosis induced by asbestos, but not by actinomycin D, was inhibited by extracellular catalase, superoxide dismutase in the presence of catalase, hypoxia (8% oxygen), deferoxamine, 3-aminobenzamide [an inhibitor of poly(ADP-ribosyl) polymerase], and cytochalasin B. Only catalase and cytochalasin B decreased fiber uptake. We conclude that asbestos induces apoptosis in mesothelial cells via reactive oxygen species. Escape from this pathway could allow the abnormal survival of mesothelial cells with asbestos-induced mutations.
A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. (1986)

1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (alkylacetyl-GPC, platelet activating factor (PAF] can be biosynthesized either by acetylation of alkyllyso-GPC through a remodeling pathway or by the transfer of phosphocholine to alkylacetyl-sn-glycerol (alkylacetyl-G) via a putative de novo pathway involving a dithiothreitol-insensitive cholinephosphotransferase. However, the relevance of the de novo pathway in the biosynthesis of PAF depends on the existence of enzymes that can directly synthesize alkylacetyl-G from 1-alkyl-2-lyso-sn-glycero-3-P (alkyllyso-GP) or some other source. In this study, we demonstrated that microsomal preparations of rat spleen can synthesize alkylacetyl-GP by an alkyllyso-GP:acetyl-CoA acetyltransferase and that this intermediate is subsequently dephosphorylated by an alkylacetyl-GP phosphohydrolase to generate alkylacetyl-G. The properties of alkyllyso-GP:acetyl-CoA acetyltransferase were characterized under conditions where the contaminating activity of alkylacetyl-GP phosphohydrolase was minimal; this was accomplished by inhibiting the phosphohydrolase with the addition of sodium vanadate and sodium fluoride to the assay mixtures and incubating at relatively low temperatures (23 degrees C). Alkyllyso-GP:acetyl-CoA acetyltransferase had a pH optimum of 8.4 at 23 degrees C and was located in the microsomal fraction. The apparent Km for acetyl-CoA under these conditions was 226 microM and the optimal concentration of alkyllyso-GP ranged between 16 and 25 microM. Based on pH optima, substrate inhibition studies, and sensitivities to preincubation temperatures of the microsomes, it appears that alkyllyso-GP:acetyl-CoA acetyltransferase differs from the acetyltransferase responsible for the transfer of acetate from acetyl-CoA to alkyllyso-GPC to form PAF. A variety of tissues had high activities of alkyllyso-GP:acetyl-CoA acetyltransferase, which indicates that this pathway is operational in many cell types. Our results document the existence of a complete de novo biosynthetic pathway for the assembly of PAF, and this route could be responsible for maintaining physiological levels of platelet activating factor for normal cell function.
Activation of calpain-1 in human carotid artery atherosclerotic lesions (2009)

These novel results suggest that calpain-1 is commonly active in carotid artery atherosclerotic plaques, and that calpain activity is colocalized with cell death and inversely associated with symptoms.
Corticosteroid therapy in regressive autism: Preliminary findings from a retrospective study (2014)

Some children with autism spectrum disorders (ASD; 15% to 30% of patients) show a significant and persistent regression in speech and social function during early childhood. There are no established treatments for the regressive symptoms. However, there are some known causes of this type of regression, such as Rett syndrome and Landau-Kleffner syndrome (LKS). In LKS, steroids have been used as a treatment. Some evidence suggests an autoimmune contribution to the pathophysiology of autism (Chez MG, Guido-Estrada N: Immune therapy in autism: historical experience and future directions with immunomodulatory therapy. Neurotherapeutics 2010, 7:293-301, Wasilewska J, Kaczmarski M, Stasiak-Barmuta A, Tobolczyk J, Kowalewska E: Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3-6 years old. Arch Med Sci 2012, 8:324-331, Stefanatos G: Changing perspectives on Landau-Kleffner syndrome. Clin Neuropsychol 2011, 25:963-988), raising the possibility that steroids might be a useful therapy for regression in ASD. A retrospective study published in BMC Neurology by Duffy et al. (Duffy, et al: Corticosteroid therapy in regressive autism: A retrospective study of effects on the Frequency Modulated Auditory Evoked Response (FMAER), language, and behavior. BMC Neurol 2014, 14:70) reviewed 20 steroid treated R-ASD (STAR) patients and 24 ASD control patients not treated with steroids (NSA). Improvements in clinical function and in a neurophysiological biomarker were seen in the steroid-treated children pre- to post-prednisolone treatment. This research provides a rationale for a randomized trial with steroid therapy to determine the longer term benefits and complications of steroids in this population.
A consideration of factors affecting future coherent lightwave communication systems (1988)

The performance limitations of coherent lightwave communication technologies are examined. Their practical device requirements, with emphasis on optical heterodyne/homodyne detection and optical frequency-division multiplexing (optical FDM) are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Kinetics of acid-catalyzed hydrolysis of carbohydrate groups of potato glycoalkaloids .alpha.-chaconine and .alpha.-solanine (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of acid-catalyzed hydrolysis of carbohydrate groups of potato glycoalkaloids .alpha.-chaconine and .alpha.-solanineMendel. Friedman, Gary. McDonald, and William F. HaddonCite this: J. Agric. Food Chem. 1993, 41, 9, 1397–1406Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jf00033a010https://doi.org/10.1021/jf00033a010research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Federal funding at a time of budget austerity (1996)

I served as chair of a committee of the National Academies of Sciences and Engineering that released a report last December entitled “Allocating Federal Funds for Science and Technology” [ National Academy Press , 1995; Carlowicz , 1995]. The report had at least one salutary effect: it triggered a lively national discussion of science policy, much of it useful but some occasionally uninformed. The report was issued in an environment that can be characterized by the end of the Cold War, changing national needs, and the restructuring of research and educational institutions. It is also a stressful time when extraordinary opportunities for scientific progress are constrained by a future of austere R&D funding as both political parties struggle to honor their commitments to balance the federal budget in 7 years. In the interest of furthering debate, I will summarize the premises of the report, the principal recommendations, the main objections that have arisen, and our responses to them.
Catalyzing Inquiry at the Interface of Computing and Biology (2005)

This study is the first comprehensive NRC study that suggests a high-level intellectual structure for Federal agencies for supporting work at the biology/computing interface. The report seeks to establish the intellectual legitimacy of a fundamentally cross-disciplinary collaboration between biologists and computer scientists. That is, while some universities are increasingly favorable to research at the intersection, life science researchers at other universities are strongly impeded in their efforts to collaborate. This report addresses these impediments and describes proven strategies for overcoming them. An important feature of the report is the use of well-documented examples that describe clearly to individuals not trained in computer science the value and usage of computing across the biological sciences, from genes and proteins to networks and pathways, from organelles to cells, and from individual organisms to populations and ecosystems. It is hoped that these examples will be useful to students in the life sciences to motivate (continued) study in computer science that will enable them to be more facile users of computing in their future biological studies.
Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy (2010)

Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. In this paper, we compile the most significant data available about biochemical and biological properties of sugar transporters in normal tissues and we review the available information about sugar carrier expression in different types of cancer. Moreover, we describe the possible pharmacological interactions between drugs currently used in anticancer therapy and the expression or function of facilitative sugar transporters. Finally, we also go into the insights about the future design of drugs targeted against sugar utilization in cancer cells.
The Metabolism of 5-Nitro-2-furaldehyde Acetylhydrazone (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Metabolism of 5-Nitro-2-furaldehyde AcetylhydrazoneJoanne. Olivard, Salvatore. Valenti, and James A. BuzardCite this: J. Med. Chem. 1962, 5, 3, 524–531Publication Date (Print):May 1, 1962Publication History Published online1 May 2002Published inissue 1 May 1962https://pubs.acs.org/doi/10.1021/jm01238a012https://doi.org/10.1021/jm01238a012research-articleACS PublicationsRequest reuse permissionsArticle Views95Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Stripline Filters - An Overview (1983)

Stripline filters and the closely related microstrip filters are coupled transmission line networks which are fabricated using one of a number of printed circuit fabrication techniques. In order to understand the operation and parameters of stripline filters it is necessary to understand the fundamentals of single and coupled transmission line resonators. The fundamental properties of transmission line resonators are reviewed, and specific examples are given for typical stripline parameters. Basic relationships are given for the size, characteristic impedance, and
Securing Cryptographic Keys in the IaaS Cloud Model (2015)

Infrastructure-as-a-Service (IaaS) is a widespread cloud computing provisioning model where ICT infrastructure, including servers, storage and networking, is supplied on-demand, in a pay-as-you-go fashion. IaaS cloud providers give their clients virtual machines (VMs) that are controlled by cloud administrators who can run, stop, restore and migrate the VMs. A typical threat to IaaS is unauthorized access of untrustworthy administrators to cloud users' sensitive information residing in VMs' memory. In this paper we focus on the threat of users' cryptographic keys being stolen from the RAM of the VM they provision. We propose a decrypt-scatter/gather-decrypt technique that allows users to carry our encryption/decryption while protecting keys from unauthorized peeks on the part of cloud administrators. Our technique does not require modification to the current cloud architecture, but only the availability of a Trusted Platform Module (TPM) capable of creating and holding a TPM-protected public/private key pair. It lends itself to security-as-a-service scenarios where third parties perform encryption/decryption on behalf of data owners.
A High-Gain Inverter With Low-Temperature Poly-Si Oxide Thin-Film Transistors (2019)

We report a complementary metal oxide semiconductor (CMOS) inverter made of p-type low-temperature poly-Si (LTPS) thin-film transistor (TFT) using blue laser annealing of amorphous Si and an n-type amorphous indium-gallium-zinc oxide (a-IGZO) TFT. The LTPS TFT exhibits a field-effect mobility, threshold voltage, and subthreshold swing of 81.76 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs, -1.1 V, and 0.65 V/dec, respectively, and the a-IGZO TFT exhibits 13.52 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Vs, 1.2 V and 0.25 V/dec, respectively. The CMOS inverter shows a full swing and a high gain of 114.28 V/V and a wide noise margin with rising and falling times of 1.44 and 3.52 μs, respectively.
The Comparative Abilities of Propofol and Sevoflurane to Modulate Inflammation and Oxidative Stress in the Kidney After Aortic Cross-Clamping (2008)

Compared with sevoflurane, propofol administration during suprarenal aortic clamping and unclamping led to modulation of markers of inflammation and decreased NFkappaB expression.
Right on Target (2002)

SUMO-1 is a recently discovered ubiquitin-like protein modifier that can be linked to various substrates. One of these is the protein RanGAP1, which activates the GTPase Ran (which cycles through GTP- and GDP-bound states) during nuclear transport and cell division. Dasso et al. find that sumoylation (addition of SUMO) was critical for the correct localization of RanGAP1 during mitosis. A mutated form of RanGAP1 that could not be sumoylated no longer associated with mitotic spindles. The spindle association of RanGAP1 also appeared to involve an interaction with a nuclear pore protein, RanBP2, that enhances sumoylation, as shown by Pichler et al. Thus, sumoylation of RanGAP1 is important for the spatial regulation of this key protein during progression through mitosis. — SMH