gebhart/patrepeval huggingface dataset:
The Identification and Characterization of a Noncontinuous Calmodulin-binding Site in Noninactivating Voltage-dependent KCNQ Potassium Channels (2002)

We show here that in a yeast two-hybrid assay calmodulin (CaM) interacts with the intracellular C-terminal region of several members of the KCNQ family of potassium channels. CaM co-immunoprecipitates with KCNQ2, KCNQ3, or KCNQ5 subunits better in the absence than in the presence of Ca2+. Moreover, in two-hybrid assays where it is possible to detect interactions with apo-CaM but not with Ca2+-bound calmodulin, we localized the CaM-binding site to a region that is predicted to contain two alpha-helices (A and B). These two helices encompass approximately 85 amino acids, and in KCNQ2 they are separated by a dispensable stretch of approximately 130 amino acids. Within this CaM-binding domain, we found an IQ-like CaM-binding motif in helix A and two overlapping consensus 1-5-10 CaM-binding motifs in helix B. Point mutations in helix A or B were capable of abolishing CaM binding in the two-hybrid assay. Moreover, glutathione S-transferase fusion proteins containing helices A and B were capable of binding to CaM, indicating that the interaction with KCNQ channels is direct. Full-length CaM (both N and C lobes) and a functional EF-1 hand were required for these interactions to occur. These observations suggest that apo-CaM is bound to neuronal KCNQ channels at low resting Ca2+ levels and that this interaction is disturbed when the [Ca2+] is raised. Thus, we propose that CaM acts as a mediator in the Ca2+-dependent modulation of KCNQ channels.
Tools of the Trade (2004)

1Susan V. White is the associate chief of nursing/quality improvement at the James A. Haley Veteran's Hospital in Tampa, FL. She is the JHQ Interviews Editor.
Enterprise Inter- and Intra-Organizational Integration: Building International Consensus (2002)

The new organizational paradigms of global cooperation and collaboration require new ways and means for their support. Information and Communication Technology (ICT) can and will play a significant role in this support. However, the many currently available and seemingly conflicting solutions, the confusing terminology, the lack of business justification, and last but not least the insufficient understanding of the technology by the end user community has significantly hampered the large scale application of the relevant ICT support and thereby the acceptance of the new paradigms. Many of these issues have been addressed in the workshops of the international initiative on Enterprise Inter- and Intra-Organizational Integration, which has been supported by the European IST Programme and NIST. The main subjects of the initiative: relations between knowledge management and business process modeling, interoperability of business processes and process models, enterprise engineering and integration, and representation of process models. Ontologies and agent technologies - the latter with their relations to ontologies and models - have been further subjects of discussions in several workshops. Results of the initiative are reported in this volume, which comprises the proceedings of the International Conference on Enterprise Integration and Modeling Technology (ICEIMT'02). The conference was sponsored by the International Federation for Information Processing (IFIP) and held in Valencia, Spain in April 2002. Enterprise Inter- and Intra-Organizational Integration: Building International Consensus provides not only a wealth of information on the state of the art of the subjects of the initiative, it also identifies opportunities for research and development. Potential projects are identified in the work group reports and some of those will be taken up by organizations involved.
Learning from Imbalanced Data (2009)

With the continuous expansion of data availability in many large-scale, complex, and networked systems, such as surveillance, security, Internet, and finance, it becomes critical to advance the fundamental understanding of knowledge discovery and analysis from raw data to support decision-making processes. Although existing knowledge discovery and data engineering techniques have shown great success in many real-world applications, the problem of learning from imbalanced data (the imbalanced learning problem) is a relatively new challenge that has attracted growing attention from both academia and industry. The imbalanced learning problem is concerned with the performance of learning algorithms in the presence of underrepresented data and severe class distribution skews. Due to the inherent complex characteristics of imbalanced data sets, learning from such data requires new understandings, principles, algorithms, and tools to transform vast amounts of raw data efficiently into information and knowledge representation. In this paper, we provide a comprehensive review of the development of research in learning from imbalanced data. Our focus is to provide a critical review of the nature of the problem, the state-of-the-art technologies, and the current assessment metrics used to evaluate learning performance under the imbalanced learning scenario. Furthermore, in order to stimulate future research in this field, we also highlight the major opportunities and challenges, as well as potential important research directions for learning from imbalanced data.
Einflüsse bei der Ultraschallprüfung austenitischer Werkstoffe / Influences on testing austenitic materials with ultrasonic / Les influences au contrôle des matériaux austénitiques par ultrasons (1979)

Article Einflüsse bei der Ultraschallprüfung austenitischer Werkstoffe / Influences on testing austenitic materials with ultrasonic / Les influences au contrôle des matériaux austénitiques par ultrasons was published on December 1, 1979 in the journal Materials Testing (volume 21, issue 12).
Technological advances to increase immunogenicity of DNA vaccines (2002)

The latest clinical data obtained with DNA vaccines against HIV and malaria have shown promise, but it is clear that when DNA vaccines are compared with other vaccine vector delivery systems, there is still room for improvement. Further development is more than possible, based on the wealth of information accumulating on methods and approaches to increase immunogenicity of DNA vaccines. Thus, the goal of this review is to summarize some of the latest technological advances to increase immunogenicity of DNA vaccines administered by the im. and id. routes. By means of examples, the review will be intended to focus only on recent developments reported in the last 2 years and likely to go towards the improvement of mucosal, humoral and cellular immune responses mostly against cancer and infectious disease antigens.
DC-bus voltage control for three-phase bi-directional inverter in DC microgrid applications (2012)

This paper presents dc-bus voltage control for a three-phase bi-directional inverter in dc-microgrid applications. The bi-directional inverter can fulfill both grid connection and rectification modes with power factor correction. The proposed control includes two approaches, one line-cycle regulation approach (OLCRA) and one-sixth line-cycle regulation approach (OSLCRA), which take into account dc-bus capacitance and regulate dc-bus voltage to track a linear relationship between dc-bus voltage and inverter inductor current. With the OLCRA, the inverter can tune the dc-bus voltage to the desired voltage accurately every line cycle, which can reduce the frequency of operation mode change and current distortion. The OSLCRA adjusts current command every one-sixth line cycle to adapt to abrupt dc-bus voltage variation. The two approaches together can prevent dc-bus voltage from dramatic change and improve the availability of the dc-microgrid without increasing dc-bus capacitance. Determination of dc-bus capacitance is also presented in this paper. Experimental results measured from a 10 kVA three-phase bidirectional inverter have verified the feasibility of the discussed control approaches.
Adaptive Performance-Aware Distributed Memory Caching (2013)

Distributed in-memory caching systems such as mem-cached have become crucial for improving the perfor-mance of web applications. However, memcached by itself does not control which node is responsible for each data object, and inefficient partitioning schemes can easily lead to load imbalances. Further, a statically sized memcached cluster can be insufficient or inefficient when demand rises and falls. In this paper we present an automated cache management system that both intel-ligently decides how to scale a distributed caching sys-tem and uses a new, adaptive partitioning algorithm that ensures that load is evenly distributed despite variations in object size and popularity. We have implemented an adaptive hashing system1 as a proxy and node control framework for memcached, and evaluate it on EC2 using a set of realistic benchmarks including database dumps and traces from Wikipedia. 1
Serum hCG Levels following the Ovulatory Injection: Associations with Patient Weight and Implantation Time (2015)

Objective. To test if serum hCG levels the morning after the ovulatory hCG injection correlate with (1) retrieval efficiency, (2) oocyte maturity, (3) embryo quality, (4) pregnancy, and/or (5) time to implantation in patients undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). Design. Retrospective cohort analysis. Setting. University-based IVF clinic. Patient(s). All IVF/ICSI cycles from April 2005 to February 2008 whose hCG administration was confirmed (n = 472 patients). Intervention(s). Serum hCG was measured the morning following the ovulatory injection, on the 16th day following retrieval, and repeated on day 18 for those with positive results. Main Outcome Measure(s). Number of follicles on the day of hCG injection, number of oocytes retrieved, maturity of oocytes, embryo quality, pregnancy outcome, and time to implantation. Result(s). hCG levels did not correlate with retrieval efficiency, oocyte maturity, embryo quality, or pregnancy. Postinjection hCG levels were inversely associated with patient weight and time to implantation. Conclusion(s). No correlation was found between hCG level and any parameter of embryo quality. Patient weight affected hCG levels following hCG injection and during the early period of pregnancy following implantation. No association between postinjection hCG level and time of implantation (adjusted for patient weight) was apparent.
A Novel Device for Optical Imaging of Blast Furnace Burden Surface: Parallel Low-Light-Loss Backlight High-Temperature Industrial Endoscope (2016)

Accurate real-time optical imaging of the burden surface shape plays an important role in improving the gas flow distribution, reducing the coke ration, and reducing the emissions of a blast furnace. To overcome the high-temperature, high-dust, and lightless environment and obtain clear images of the burden surface, a parallel low-light-loss backlight high-temperature industrial endoscope is developed. The design of a parallel low-light-loss backlight path and a high-light-efficiency, low-light, color backlight source overcomes the lightlessness issue. Combined with the endoscopic optical imaging method, a high-temperature resistant image-capturing lens and a high-temperature non-resistant photosensitive chip are separated at two ends of the instrument. This separation design method together with the water cooling and industrial nitrogen cooling system enables the equipment to overcome the high temperature issue. Moreover, a new installation strategy, which avoids the material flow and high-dust region, is proposed to overcome the high dust issue. The strategy includes establishing a trajectory model of dust particles to determine the low-dust area and conducting a landing points experiment and a trajectory model of the material flow to determine the no-material-flow region. The industrial experiment results indicate that the developed device obtains real-time images of the burden surface and exhibits clear details of the coke and iron ore particles. The application also demonstrates the validity and better imaging performance of the proposed method compared with conventional detection methods.
Ultrafast all-optical tuning of magnetic modes in GaAs metasurfaces (2017)

We experimentally realize an ultrafast tunable metasurface consisting of subwave-length gallium arsenide nanoparticles supporting Mie-type resonances, which are all-optically tuned by 30 nm in spectral domain under pump fluences as low as < 400 μJ/cm2.
A rapid fluorescent multiplexed‐PCR analysis (FMPA) for founder mutations in the <i>BRCA</i>1 and <i>BRCA</i>2 genes (2000)

Mutations of the BRCA1 and BRCA2 genes account for approximately 80% of hereditary breast/ovarian cancer families, but the size of these two genes makes mutation analysis time-consuming and technically challenging. In some populations such as the Ashkenazi Jewish and the French-Canadian, a small number of recurrent founder mutations account for the majority of mutations in cancer families. We have therefore developed two rapid genetic screening tests, which allow us to detect three frequent frameshift mutations in the Ashkenazi Jewish population and five frameshift mutations in the French-Canadian population. These fluorescent non-radioactive methods permit the simultaneous detection of multiple mutations by generating multiplexed PCR-amplified gene fragments, and by discriminating these on the basis of their size in a denaturing polyacrylamide gel. Using these methods, we were able to correctly identify all mutants in a blinded analysis of 276 DNA samples, including 30 derived from paraffin-embedded tumor samples and 10 from buccal-cell brushes, with no false positive or false negative results. These techniques designed for the direct detection of recurrent mutations in the BRCA1 and BRCA2 genes, have the advantages of being efficient, sensitive, cost-effective, and are applicable to large scale screening for epidemiologic studies.
Characterization of rapidly annealed Mo–polycide (1985)

Mo-polycide structures were fabricated by sputtering 0.3 μm MoSi2 films onto a 0.3 μm phosphorus doped poly-Si layer using a cold pressed composite target. The properties of the Mo-polycide layers were investigated before and after rapid thermal annealing (RTA) in a tungsten halogen lamp system. The anneal temperatures were varied between 800 and 1200 °C and the cycle duration from 2 to 30 s. A minimum sheet resistance of 2.8 Ω/⧠ was obtained after a 10 s RTA cycle at 1100 °C. RBS analysis indicated no change in the film stoichiometry after the RTA treatment. However, rapid diffusion of phosphorus into the silicide film was observed by SIMS analysis. In addition, a sheet resistance increase was observed after RTA at 1200 °C and is attributed to the formation of voids in the silicide films.
Thermodynamics of AlN Formation in High Manganese-Aluminum Alloyed Liquid Steels (2013)

The AlN solubility product in liquid iron containing manganese up to 22 mass% were measured by the metal-nitride-gas equilibration technique in the temperature range from 1823 to 1873 K. Manganese significantly increased the AlN solubility product in liquid iron primarily due to the large effect of manganese on the nitrogen solubility. Using the Wagner’s formalism, the experimental results were thermodynamically analyzed to determine the thermodynamic interaction parameters between manganese and aluminum in high Mn–Al alloyed liquid steels as follows;
P.S. (1911)

Journal Article P.S. Get access John T. Page John T. Page Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s11-III, Issue 57, 28 January 1911, Page 71, https://doi.org/10.1093/nq/s11-III.57.71c Published: 28 January 1911
Modular Multitask Reinforcement Learning with Policy Sketches (2016)

We describe a framework for multitask deep reinforcement learning guided by policy sketches. Sketches annotate tasks with sequences of named subtasks, providing information about high-level structural relationships among tasks but not how to implement them---specifically not providing the detailed guidance used by much previous work on learning policy abstractions for RL (e.g. intermediate rewards, subtask completion signals, or intrinsic motivations). To learn from sketches, we present a model that associates every subtask with a modular subpolicy, and jointly maximizes reward over full task-specific policies by tying parameters across shared subpolicies. Optimization is accomplished via a decoupled actor--critic training objective that facilitates learning common behaviors from multiple dissimilar reward functions. We evaluate the effectiveness of our approach in three environments featuring both discrete and continuous control, and with sparse rewards that can be obtained only after completing a number of high-level subgoals. Experiments show that using our approach to learn policies guided by sketches gives better performance than existing techniques for learning task-specific or shared policies, while naturally inducing a library of interpretable primitive behaviors that can be recombined to rapidly adapt to new tasks.
Composite Right/Left-Handed Transmission Lines Based on Conductor-Backed Coplanar Strips (2006)

We propose here a composite right/left handed transmission line constructed by using conductor-backed coplanar strips. In this line, we can easily realize a shunt inductor without via because it has the electric-wall symmetry at the guide center. The left-handed nature is verified by both the finite difference time-domain (FDTD) and the equivalent-circuit calculations. Furthermore, we demonstrate the proposed line can easily satisfy the balanced condition for no band gap between the right-handed and the left-handed modes, and can be applied to a leaky-wave antenna, numerically and experimentally.
Time-Frequency Networks for Audio Super-Resolution (2018)

Audio super-resolution (a.k.a. bandwidth extension) is the challenging task of increasing the temporal resolution of audio signals. Recent deep networks approaches achieved promising results by modeling the task as a regression problem in either time or frequency domain. In this paper, we introduced Time-Frequency Network (TFNet), a deep network that utilizes supervision in both the time and frequency domain. We proposed a novel model architecture which allows the two domains to be jointly optimized. Results demonstrate that our method outperforms the state-of-the-art both quantitatively and qualitatively.
Turbo codes for PR4 and EPR4 magnetic recording (2002)

This paper presents further results of the application of turbo codes to magnetic recording channels. A rate 16/17 turbo code has been simulated on both a preceded PR4 and EPR4-equalized Lorentzian channel. Gains of 4.4 dB and 3.9 dB are obtained respectively, thus encouraging continued research in this area where high rate codes are desirable. A rate 13/14 convolutional code has also been applied to a PR4-equalized channel. It results in 1.2 dB less gain than the rate 16/17 turbo code on the same channel and therefore indicates the turbo code parity bit is more powerful in comparison to a convolutional code parity bit.
Electrodeposition of Cobalt from Aqueous Chloride Solutions (1990)

Electrodeposition of cobalt in aqueous chloride solutions has been studied by means of cyclic voltammetry and potentiostatic current‐time transient techniques on rotating nickel disk electrodes. The electrocrystallization of cobalt is via a three‐dimensional progressive nucleation and crystal growth mechanism under interfacial electron transfer/mass transfer control. As the deposition proceeds, concentration polarization becomes increasingly important after the nickel disk electrode is nearly or fully covered by cobalt crystallites. However, as the bulk concentration of Co2+ ions increases, the kinetics of the nucleation and crystal growth is increasingly dominated by interfacial electron transfer. It has also been found that in the electrodeposition process influenced by both interfacial/mass transfer processes, the electrode kinetics parameters can be obtained by analyzing the cathodic current responses of the reverse sweeps on the voltammetric curves. The measured Tafel slope of 29 mV and diffusion coefficient of are in good agreement with the values reported in the literature.
Statistical process control for nonnormally distributed variables through the use of transformations (2002)

The use of normalizing transformations that allow the use of standard SPC (statistical process control) procedures is discussed. A case study is presented to illustrate the use of tests for normality, of normalizing transformations, and the subsequent calculation of the control limits and construction of the SPC graph. It is shown that using normalizing transformations provides a viable method to monitor and control nonnormally distributed variables using standard SPC methods. This approach reduces the rate of false alarms, allows the use of the AT&T rules to detect trends in the data, increases confidence in the ability of SPC to detect points out of control, and uses standard SPC methods, so that learning new procedures is not necessary. One drawback of this method may be that the ordinate of the SPC chart is in the units of the transformed variable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Molecular Parameters of Type IV α-Internexin and Type IV-Type III α-Internexin-Vimentin Copolymer Intermediate Filaments (1999)

During neuronal development, a dynamic replacement mechanism occurs in which the type VI nestin and type III vimentin intermediate filament proteins are replaced by a series of type IV proteins beginning with alpha-internexin. We have explored molecular details of how the type III to type IV replacement process may occur. First, we have demonstrated by cross-linking experiments that bacterially expressed forms of alpha-internexin and vimentin form heterodimer molecules in vitro that assemble into copolymer intermediate filaments. We show using a urea disassembly assay that alpha-internexin molecules are likely to be more stable than those of vimentin. Second, by analyses of the induced cross-links, we have determined the axial lengths of alpha-internexin homodimer and alpha-internexin-vimentin heterodimer molecules and their modes of alignments in filaments. We report that these dimensions are the same as those reported earlier for vimentin homopolymer molecules and, by implication, are also the same for the other neuronal type IV proteins. These data suggest that during neuronal development, alpha-internexin molecules are readily assimilated onto the pre-existing vimentin cytoskeletal intermediate filament network because the axial lengths and axial alignments of their molecules are the same. Furthermore, the dynamic replacement process may be driven by a positive equilibrium due to the increased stability of the alpha-internexin network.
A differential interferometer for scanning force microscopy (1994)

A magnetic force instrument is described which makes use of a differential interferometer which can be used with a very short length cantilever in the force detection assembly. Conventional methods work with cantilevers of a few millimetres in length, but are not suitable for the very much smaller commercial cantilevers which are now available. The instrument described contains novel features which enable it to be used with such cantilevers. Topographical images of calibration specimens and magnetic images of hard disk samples obtained using this instrument are presented.