gebhart/patrepeval huggingface dataset:
TRANSLATIONAL REGULATION OF<i>GCN4</i>AND THE GENERAL AMINO ACID CONTROL OF YEAST (2005)

Cells reprogram gene expression in response to environmental changes by mobilizing transcriptional activators. The activator protein Gcn4 of the yeast Saccharomyces cerevisiae is regulated by an intricate translational control mechanism, which is the primary focus of this review, and also by the modulation of its stability in response to nutrient availability. Translation of GCN4 mRNA is derepressed in amino acid-deprived cells, leading to transcriptional induction of nearly all genes encoding amino acid biosynthetic enzymes. The trans-acting proteins that control GCN4 translation have general functions in the initiation of protein synthesis, or regulate the activities of initiation factors, so that the molecular events that induce GCN4 translation also reduce the rate of general protein synthesis. This dual regulatory response enables cells to limit their consumption of amino acids while diverting resources into amino acid biosynthesis in nutrient-poor environments. Remarkably, mammalian cells use the same strategy to downregulate protein synthesis while inducing transcriptional activators of stress-response genes under various stressful conditions, including amino acid starvation.
Use of Underpotential Deposition of Zinc to Mitigate Hydrogen Absorption into Monel K500 (1994)

Polarization experiments and a potentiostatic pulse technique have been used to show that a monolayer coverage of zinc effectively inhibits the absorption of hydrogen into Monel K500. By depositing a monolayer of zinc on Monel K500, the hydrogen evolution reaction and hydrogen ingress flux rate were reduced by 60%.
New Microstrip Gap Waveguide on Mushroom-Type EBG for Packaging of Microwave Components (2012)

The gap waveguide has been recently presented as a new transmission line technology using artificial magnetic conductors (AMCs) to allow the wave propagation only along a desired path. The first validation has been provided using a lid of metal pins as AMC for high frequency applications. In this letter, simulations and measurement results are presented for another version called microstrip gap waveguide, working as inverted microstrip line and realized using a mushroom-type EBG surface. The transmission line is surrounded by mushrooms which create a parallel plate stop band, suppressing cavity modes and unwanted radiations compared to standard packaged microstrip transmission lines. The field propagates in the air gap between the upper lid and the mushrooms layer, providing a low loss compact circuit made in printed technology.
Silicon micromachined gas chromatography system (2002)

A miniature gas chromatography (GC) system has been designed and fabricated using silicon micromachining and integrated circuit (IC) processing techniques. The silicon micromachined gas chromatography system (SMGCS) is composed of a miniature sample injector that incorporates a 10 /spl mu/l sample loop; a 0.9-m long, rectangular-shaped (300 /spl mu/m width and 10 /spl mu/m height) capillary column coated with a 0.2-/spl mu/m thick copper phthalocyanine (CuPc) stationary-phase; and a dual-detector scheme based upon a CuPc-coated chemiresistor and a commercially available, 125-/spl mu/m diameter thermal conductivity detector (TCD) bead. Silicon micromachining was employed to fabricate the interface between the sample injector and the GC column, the column itself, and the dual-detector cavity. A novel IC thin-film processing technique was developed to sublime the CuPc stationary-phase coating on the column walls that were micromachined in the host silicon wafer substrate and Pyrex cover plate, which were then electrostatically bonded together. The SMGCS can separate binary gas mixtures composed of parts per-million (ppm) concentrations of ammonia (NH/sub 3/) and nitrogen dioxide (NO/sub 2/) when isothermally operated (55-80/spl deg/C). With a helium carrier gas and nitrogen diluent, a 10 /spl mu/l sample volume containing ammonia and nitrogen dioxide injected at 40 psi (2.8/spl times/10/sup 5/ Pa) can be separated in less than 30 minutes.
Deep Structure Learning for Fraud Detection (2018)

Fraud detection is of great importance because fraudulent behaviors may mislead consumers or bring huge losses to enterprises. Due to the lockstep feature of fraudulent behaviors, fraud detection problem can be viewed as finding suspicious dense blocks in the attributed bipartite graph. In reality, existing attribute-based methods are not adversarially robust, because fraudsters can take some camouflage actions to cover their behavior attributes as normal. More importantly, existing structural information based methods only consider shallow topology structure, making their effectiveness sensitive to the density of suspicious blocks. In this paper, we propose a novel deep structure learning model named DeepFD to differentiate normal users and suspicious users. DeepFD can preserve the non-linear graph structure and user behavior information simultaneously. Experimental results on different types of datasets demonstrate that DeepFD outperforms the state-of-the-art baselines.
Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding (2013)

Endothelial cells (ECs) are covered by a surface glycocalyx layer that forms part of the barrier and mechanosensing functions of the blood-tissue interface. Removal of albumin in bathing media induces collapse or shedding of the glycocalyx. The electrostatic interaction between arginine residues on albumin, and negatively charged glycosaminoglycans (GAGs) in the glycocalyx have been hypothesized to stabilize the glycocalyx structure. Because albumin is one of the primary carriers of the phospholipid sphingosine-1-phosphate (S1P), we evaluated the alternate hypothesis that S1P, acting via S1P1 receptors, plays the primary role in stabilizing the endothelial glycocalyx. Using confocal microscopy on rat fat-pad ECs, we demonstrated that heparan sulfate (HS), chondroitin sulfate (CS), and ectodomain of syndecan-1 were shed from the endothelial cell surface after removal of plasma protein but were retained in the presence of S1P at concentrations of >100 nM. S1P1 receptor antagonism abolished the protection of the glycocalyx by S1P and plasma proteins. S1P reduced GAGs released after removal of plasma protein. The mechanism of protection from loss of glycocalyx components by S1P-dependent pathways was shown to be suppression of metalloproteinase (MMP) activity. General inhibition of MMPs protected against loss of CS and syndecan-1. Specific inhibition of MMP-9 and MMP-13 protected against CS loss. We conclude that S1P plays a critical role in protecting the glycocalyx via S1P1 and inhibits the protease activity-dependent shedding of CS, HS, and the syndecan-1 ectodomain. Our results provide new insight into the role for S1P in protecting the glycocalyx and maintaining vascular homeostasis.
Multistage partially adaptive STAP CFAR detection algorithm (1999)

A new method of partially adaptive constant false-alarm rate (CFAR) detection is introduced. The processor implements a novel sequence of orthogonal subspace projections to decompose the Wiener solution in terms of the cross-correlation observed at each stage. The performance is evaluated using the general framework of space-time adaptive processing (STAP) for the cases of both known and unknown covariance. It is demonstrated that this new approach to partially adaptive STAP outperforms the more complex eigen-analysis approaches using both simulated DARPA Mountain Top data and true pulse-Doppler radar data collected by the MCARM radar.
Energy levels of Zn in Si1−XGeX alloys (1998)

Deep level transient spectroscopy measurements were performed on Zn-doped Si1−XGeX with X between 0 and 0.34. Our investigations reveal two deep hole traps which are attributed to the acceptor states Zn0/− and Zn−/2− of substitutional Zn. Taking into account band-offset data for Si1−XGeX, we have found that the energy level related to Zn0/− is horizontally aligned across the composition-dependent band gap which gives evidence for a highly localized defect state. The defect level related to the second hole trap decreases with increasing Ge content.
Optimization of enzymatic reaction conditions for generating representative pools of cDNA from small RNA (2010)

Small regulatory RNA repertoires in biological samples are heterogeneous mixtures that may include species arising from varied biosynthetic pathways and modification events. Small RNA profiling and discovery approaches ought to capture molecules in a way that is representative of expression level. It follows that the effects of RNA modifications on representation should be minimized. The collection of high-quality, representative data, therefore, will be highly dependent on bias-free sample manipulation in advance of quantification. We examined the impact of 2'-O-methylation of the 3'-terminal nucleotide of small RNA on key enzymatic reactions of standard front-end manipulation schemes. Here we report that this common modification negatively influences the representation of these small RNA species. Deficits occurred at multiple steps as determined by gel analysis of synthetic input RNA and by quantification and sequencing of derived cDNA pools. We describe methods to minimize the effects of 2'-O-methyl modification of small RNA 3'-termini using T4 RNA ligase 2 truncated, and other optimized reaction conditions, demonstrating their use by quantifying representation of miRNAs and piRNAs in cDNA pools prepared from biological samples.
P[N(<i>i-</i>Bu)CH<sub>2</sub>CH<sub>2</sub>]<sub>3</sub>N: Nonionic Lewis Base for Promoting the Room-Temperature Synthesis of α,β-Unsaturated Esters, Fluorides, Ketones, and Nitriles Using Wadsworth−Emmons Phosphonates (2010)

The bicyclic triaminophosphine P(RNCH(2)CH(2))(3)N (R = i-Bu, 1c) serves as an effective promoter for the room-temperature stereoselective synthesis of α,β-unsaturated esters, fluorides, and nitriles from a wide array of aromatic, aliphatic, heterocyclic, and cyclic aldehydes and ketones, using a range of Wadsworth-Emmons (WE) phosphonates. Among the analogues of 1c [R = Me (1a), i-Pr (1b), Bn (1d)], 1a and 1b performed well, although longer reaction times were involved, and 1d led to poorer yields than 1c. Functionalities such as cyano, chloro, bromo, methoxy, amino, ester, and nitro were well tolerated. We were able to isolate and characterize (by X-ray means; see above) the reactive WE intermediate species formed from 2b and 1c.
Automatic registration between 3D intra-operative ultrasound and pre-operative CT images of the liver based on robust edge matching (2011)

The registration of a three-dimensional (3D) ultrasound (US) image with a computed tomography (CT) or magnetic resonance image is beneficial in various clinical applications such as diagnosis and image-guided intervention of the liver. However, conventional methods usually require a time-consuming and inconvenient manual process for pre-alignment, and the success of this process strongly depends on the proper selection of initial transformation parameters. In this paper, we present an automatic feature-based affine registration procedure of 3D intra-operative US and pre-operative CT images of the liver. In the registration procedure, we first segment vessel lumens and the liver surface from a 3D B-mode US image. We then automatically estimate an initial registration transformation by using the proposed edge matching algorithm. The algorithm finds the most likely correspondences between the vessel centerlines of both images in a non-iterative manner based on a modified Viterbi algorithm. Finally, the registration is iteratively refined on the basis of the global affine transformation by jointly using the vessel and liver surface information. The proposed registration algorithm is validated on synthesized datasets and 20 clinical datasets, through both qualitative and quantitative evaluations. Experimental results show that automatic registration can be successfully achieved between 3D B-mode US and CT images even with a large initial misalignment.
PRODUCTION AND PURIFICATION OF CELLULOSE- DEGRADING ENZYMES FROM A FILAMENTOUS FUNGUS TRICHODERMA HARZIANUM (2009)

The major components of plant cell walls are cellulose, hemicellulose and lignin, with cellulose being the most abundant component. Cellulose degrading-enzymes provide a key opportunity for achieving tremendous benefits of biomass utilization. Trichoderma harzianum, a filamentous fungus, produces cellulose degrading enzymes and has been exploited by the industry. In this study, three cellulases, exoglucanase (EXG), endoglucanase (EG) and β-glucosidase (BGL) were partially purified from T. harzianum. The optimal pH, temperature and incubation time for cellulases production was found to be 5.5, 28 o C and 120 h respectively. To promote cellulases production, we evaluated the effects of glucose, carboxymethylcellulose (CMC), corn cobs, birchwood xylan and wheat bran as carbon sources for cellulase production. The results showed that CMC induced cellulases production whereas glucose repressed the synthesis of cellulases. The fungus was cultivated with 1% CMC for 120 h at 28oC, pH 5.5 and the resulting culture filtrate was used for cellulase purification. EXG, EG and BGL were partially purified from culture filtrate of fungus by Ammonium sulfate precipitation followed by gel filtration chromatography on Sephadex G200 and on Sephadex G50. After final purification step specific activities (IU/mg -1 ) of the enzymes were; EXG: 49.22, EG: 0.63 and BGL: 0.35 with 21.87-, 7.15- and 1.74- fold purification, respectively.
Programming Microsoft Windows CE with Cdrom (1998)

From the Publisher:
Programming Microsoft Windows CE guides Windows programmers through the unique problems and the new opportunities provided by Windows CE. The book covers all the new Win32® APIs supported by Windows CE as well as workarounds for Win32 APIs not supported. The book also covers programming techniques necessary when programming for memory-constrained environments. While MFC for Windows CE is discussed, the primary focus of the book is programming directly to the Windows CE API since that is what most programmers need to do to meet the size and speed requirements necessary for well-designed Windows CE programs. The Windows CE Software Development Kit and sample code are included on the CD.
Preparatory Set Associated With Pro-Saccades and Anti-Saccades in Humans Investigated With Event-Related fMRI (2003)

Previous studies have shown that the BOLD functional MRI (fMRI) signal is increased in several cortical areas when subjects perform anti-saccades compared with pro-saccades. It remains unknown, however, whether this increase is due to an increased cortical motor signal for anti-saccades or due to differences in preparatory set between pro- and anti-saccade trials. To address this question, we measured event-related fMRI in a paradigm that allowed us to separate instruction-related brain activity from saccade-related brain activity. In this paradigm, the instruction to either generate a pro-saccade or an anti-saccade was conveyed by a switch in the color of the central fixation stimulus and preceded the presentation of a peripheral stimulus by either 6, 10, or 14 s. Cortical areas were functionally mapped using the general linear model comparing standard pro- and anti-saccade blocks with fixation blocks. When the trials were aligned on the onset of the instruction stimulus, bilateral frontal eye fields and right hemisphere dorsolateral prefrontal cortex showed an increased signal during the instruction period on anti-saccade trials as compared with pro-saccade trials. When the trials were aligned on the movement stimulus and the instruction period activity was subtracted, there were no differences between pro- and anti-saccades. This finding suggests that the increased cortical activation found in previous blocked designs originates predominately from differences in preparatory set and not from differences in the motor signal between pro- and anti-saccades.
About the Acidity-Catalytic Activity Relationship in Ionic Liquids: Application to the Selective Isobutene Dimerization (2009)

The Brønsted acidity level was evaluated for ionic liquids to which a strong acid has been added. As a first approach, the evaluation method was based on the determination of the Hammett acidity functions H0, using UV-Visible spectroscopy. The acidity of protons is mainly determined by their solvation state and consequently, the properties of protons depend on both the nature of the solvent and the nature and concentration of the acid. An apparent acidity scale was defined following this principle. It was found that, for the investigated ionic liquids, the cation does not play a dominant role on the acidity level ([BMIm] ~ [BHIm] ~ [ HNEt3] ), whereas changing the nature of the anion of the ionic liquid may lead to very different acidities ([ SbF6] > [ PF6] > [ BF4] > [ NTf2] > [OTf]). This “acidity scale” was tentatively compared with an “activity scale” obtained for the dimerization of isobutene into isooctenes. The tendencies concerning the cation effect were confirmed ([BMIm] ~ [BuMePyrr] ~ [ HNEt3] ). The anion effect in only partially validated with a different behaviour for NTf2 type ionic liquids ([ NTf2] ~ [ SbF6] > [ PF6] ~ [ BF4] > [OTf]). By an adequate choice of the ionic liquid, selectivity for isobutene dimers can reach 88 wt% (at 70% isobutene conversion) with possible recycling of the catalytic system without loss of activity and selectivity.
REVIEWS OF RECORDS (1958)

Journal Article REVIEWS OF RECORDS Get access SCHOENBERG: Verklä rte Nacht, Op. 4; Chamber Symphony, Op. 9. Symphony Orchestra of the Southwest German Radio, Baden-Baden, cond. Jascha Horenstein. 12″. Vox PL 10,460. ROBERT CRAFT ROBERT CRAFT Search for other works by this author on: Oxford Academic Google Scholar The Musical Quarterly, Volume XLIV, Issue 2, April 1958, Pages 271–273, https://doi.org/10.1093/mq/XLIV.2.271 Published: 01 April 1958
Active phase stabilization in Fourier-transform two-dimensional infrared spectroscopy (2005)

A scheme for active phase stabilization and absolute positioning in Fourier-transform two-dimensional (2D) IR spectroscopy is presented. The position accuracy is better than 20 nm(rms) corresponding to lambda/250 at 5 microm, which significantly improves the quality of Fourier-transform 2D IR spectra. Phase stabilization is added to a standard photon echo setup in a way that does not impair the flexibility of the experiment and the control over IR pulse parameters.
Disulphide Connectivity Prediction in Proteins Based on Secondary Structures and Cysteine Separation. (2005)

The disulphide bonds are important in deciding the final 3D conformation of protein. Knowing disulphide connectivity will help to find out the final protein conformation, as it will limit the conformational search space. Fariselli and Casadio[1] approached problem of predicting disulphide connectivity by equating the problem to a maximum graph matching problem and assigning edge weights based on the residues in the nearest neighborhoods of the cysteines. This paper modifies the weights by adding constraints based on secondary structure and separation between the cysteines in the protein chain. Prediction results show considerable improvement. The prediction results can provide insight into the protein folding and disulphide bond formation as they are supporting the hypothesis on which the objective function is based upon 1.
THE SYSTEMIC SEPTIC RESPONSE (1979)

Wiles, John B. M.D.; Cerra, Frank B. M.D.; Siegel, John H. M.D.; Border, John R. M.D. Author Information
New Grids for Robust Reservoir Modeling (2008)

Abstract Geostatistical modeling of reservoir facies and petrophysical properties (e.g. porosity and permeability) must be performed in a pre-faulted, deposition space in order to reproduce the true spatial correlations of these properties. A transformation function is therefore required to bring the data from the current position of the reservoir into the modeling space where experimental variograms are computed; reservoir properties are then stochastically simulated in the deposition space and mapped back to the real space. Current reservoir modeling practice uses a stratigraphic grid to conform to the reservoirs structure (bounding horizons and faults). The (i, j, k)-indexing of the nodes of the cells is used as a discretization of a curvilinear coordinate system which acts as the transfer function to the deposition space. This leads to a very strong underlying assumption: the geological distances (in the deposition space) are a function of the (i, j, k)-indexing. In the presence of non-vertical faults, the cells of the stratigraphic grids are either stretched or squeezed, violating this assumption. Moreover, in the presence of complex structural geology, these grids simply cannot be constructed without tremendous simplifications. The new proposed approach uses a 3D parameterization of the subsurface yielding a grid that minimizes the distortions of distances imposed by geostatistical simulation algorithms. These new Geologic Grids allow the construction of robust reservoir models whatever the structural complexity of the reservoir. Additionally, they guarantee the accurate mapping and upscaling of reservoir properties into either structured or unstructured Flow Simulation Grids. They also enable the creation of structured Flow Simulation Grids in which faults are defined as stair-steps allowing representation of the complete reservoir structure and ensuring orthogonality of cells.
Multimetallic ruthenium(II) complexes based on biimidazole and bibenzimidazole: effect of dianionic bridging ligands on redox and spectral properties (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultimetallic ruthenium(II) complexes based on biimidazole and bibenzimidazole: effect of dianionic bridging ligands on redox and spectral propertiesD. Paul Rillema, Ram Sahai, Philomina Matthews, A. Kirk Edwards, Randy J. Shaver, and Larry MorganCite this: Inorg. Chem. 1990, 29, 2, 167–175Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ic00327a006https://doi.org/10.1021/ic00327a006research-articleACS PublicationsRequest reuse permissionsArticle Views769Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts