gebhart/patrepeval huggingface dataset:
Identification of a Novel A20-binding Inhibitor of Nuclear Factor-κB Activation Termed ABIN-2 (2001)

The nuclear factor kappaB (NF-kappaB) plays a central role in the regulation of genes implicated in immune responses, inflammatory processes, and apoptotic cell death. The zinc finger protein A20 is a cellular inhibitor of NF-kappaB activation by various stimuli and plays a critical role in terminating NF-kappaB responses. The underlying mechanism for NF-kappaB inhibition by A20 is still unknown. A20 has been shown to interact with several proteins including tumor necrosis factor (TNF) receptor-associated factors 2 and 6, as well as the inhibitory protein of kappaB kinase (IKK) gamma protein. Here we report the cloning and characterization of ABIN-2, a previously unknown protein that binds to the COOH-terminal zinc finger domain of A20. NF-kappaB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2. The latter also inhibits NF-kappaB activation induced by overexpression of receptor-interacting protein or TNF receptor-associated factor 2. In contrast, NF-kappaB activation by overexpression of IKKbeta or direct activators of the IKK complex, such as Tax, cannot be inhibited by ABIN-2. These results indicate that ABIN-2 interferes with NF-kappaB activation upstream of the IKK complex and that it might contribute to the NF-kappaB-inhibitory function of A20.
Source wavelet estimation by upward extrapolation (1988)

Abstract A new deterministic technique for wavelet estimation and deconvolution of seismic traces was recently introduced. This impedance-type technique was developed for a marine environment where both the source and the receivers are located inside a homogeneous layer of water.In this work, an extension of the theory of source wavelet estimation is proposed. As in previous publications, this method is based on extrapolation of the wave field measured at depth, upward to the free surface. The extrapolation is performed by using the finite-difference approximation to the full inhomogeneous wave equation. The extrapolation results in a wavelet which generally includes ghosts and can be used for source signature deconvolution and deghosting. The method needs two closely spaced receivers and is applicable for arbitrary locations of the source and the receivers in one-dimensional multilayered models, provided the source is above the receivers; furthermore, it can be applied to both marine and land data. Application of the proposed method to a number of synthetic models shows that it gives a good estimate of the source wavelet.
Expression and localization of renin and angiotensinogen in rat heart after myocardial infarction (1996)

Wistar-Kyoto rats underwent myocardial infarction (MI) or sham surgery. At different time points after surgery (1-90 days), hearts were removed and divided into infarcted left ventricle (LV), noninfarcted septum, and right ventricle. The tissues were used for total RNA isolation or Formalin fixation for in situ hybridization (ISH). Renin and angiotensinogen mRNA contents were quantified by the competitive reverse transcriptase polymerase chain reaction. We found a 4-, 14-, and 8-fold increase (P < 0.05, n = 6) in renin mRNA in the infarcted LV at 2, 4, and 7 days after MI, respectively. No differences were observed between angiotensinogen mRNA levels in sham and infarcted hearts. ISH at 4 days after surgery revealed a dense renin mRNA labeling around the infarcted area, whereas ISH of angiotensinogen displayed an overall low density in the myocardium with somewhat higher levels in the epicardium of sham and MI animals. Atrial natriuretic factor mRNA, a marker for cardiac hypertrophy, was approximately twofold higher in all compartments of the hearts after MI. The low amounts of renin and angiotensinogen mRNA in the noninfarcted hypertrophied myocardium indicate that the intracardiac synthesis of these components does not play a dominant role in the development of cardiac hypertrophy in the rat heart after MI. In addition, the increased renin mRNA expression in the border zone of the infarcted LV suggests a role for intracardiac angiotensin II in infarct healing.
<title>Solar cells from C<formula><inf><roman>60</roman></inf></formula></title> (1995)

The paper outlines several unique properties of C<SUB>60</SUB> (environmental, electronic, and structural), compared to standard semiconductors such as Si and GaAs, that render it a most promising material for the fabrication of high-efficiency photovoltaic cells. Details are presented of an experimental Schottky barrier solar cell we have constructed using a single crystal of C<SUB>60</SUB>. Preliminary results of our experimental studies of the optical properties of crystalline and amorphous C<SUB>60</SUB> films are discussed.
Pattern recognition of MRSI data shows regions of glioma growth that agree with DTI markers of brain tumor infiltration (2009)

Gliomas are the most common primary brain tumors and the majority are highly malignant, with one of the worst prognoses for patients. Gliomas are characterized by invasive growth into normal brain tissue that makes complete surgical resection and accurate radiotherapy planning extremely difficult. We have performed independent component analysis of magnetic resonance spectroscopy imaging data from human gliomas to segment brain tissue into tumor core, tumor infiltration, and normal brain, with confirmation by diffusion tensor imaging analysis. Our data are consistent with previous studies that compared anomalies in isotropic and anisotropic diffusion images to determine regions of potential glioma infiltration. We show that coefficients of independent components can be used to create colored images for easy visual identification of regions of infiltrative tumor growth.
Resistance to Tumor Growth Mediated by Listeria Monocytogenes. Destruction of Experimental Malignant Melanoma by Lm-Activated Peritoneal and Lymphoid Cells (1976)

Abstract A murine experimental model of nonspecific tumor destruction mediated by cells activated by Listeria monocytogenes (LM) is described. B16 melanoma growth is prevented or suppressed in the syngeneic host when tumor cells are inoculated in contact with viable LM. In vitro, cultured B16 cells are destroyed by LM immune peritoneal or splenic cells in the presence of the bacterial antigen(s). Activation of LM immune cells in vitro is immunologically specific. Replacement of LM by sheep red blood cells or bovine serum albumin in the in vitro cultures aborts the cytotoxic effect. Further, no tumor cell killing is obtained when thioglycollate-induced or normal peritoneal cells are substituted for LM immune cells in the in vitro cultures. Normal spleen cells in the presence of LM are weakly cytotoxic for B16 cells. Normal peritoneal cells plus LM or LM alone are not. Elimination of thymus derived “T” cells by anti-θ C3H or rabbit anti-mouse brain serum (RAMB) abrogated the cytotoxic effect. Therefore, LM-induced tumor destruction probably occurs through nonspecific mechanism(s) consequent to activation of host “T” cells by specific immune reactivity to LM antigen(s).
A survey of modern authorship attribution methods (2008)

Abstract Authorship attribution supported by statistical or computational methods has a long history starting from the 19th century and is marked by the seminal study of Mosteller and Wallace (1964) on the authorship of the disputed “Federalist Papers.” During the last decade, this scientific field has been developed substantially, taking advantage of research advances in areas such as machine learning, information retrieval, and natural language processing. The plethora of available electronic texts (e.g., e‐mail messages, online forum messages, blogs, source code, etc.) indicates a wide variety of applications of this technology, provided it is able to handle short and noisy text from multiple candidate authors. In this article, a survey of recent advances of the automated approaches to attributing authorship is presented, examining their characteristics for both text representation and text classification. The focus of this survey is on computational requirements and settings rather than on linguistic or literary issues. We also discuss evaluation methodologies and criteria for authorship attribution studies and list open questions that will attract future work in this area.
Consumer engagement with brands on social network sites: A cross-cultural comparison of China and the USA (2014)

To advance theoretical understanding of consumer engagement on social media, this cross-cultural study evaluates how culture influences consumers’ engagement levels and activities on brand pages of social network sites. It further evaluates the underlying motivations and engagement mechanisms in two culturally distinct countries, China and the USA. Specifically, social media dependency, parasocial interaction, and community identification are examined as the key antecedents of consumer-brand engagement. The results confirm the effects of the proposed antecedents and reveal both cultural differences and similarities between Chinese and American consumers’ engagement with brand pages on social network sites.
Categorization and naming in children: problems of induction (1990)

In this landmark work on early conceptual and lexical development, Ellen Markman explores the fascinating problem of how young children succeed at the task of inducing concepts. Backed by extensive experimental results, she challenges the fundamental assumptions of traditional theories of language acquisition and proposes that a set of constraints or principles of induction allows children to efficiently integrate knowledge and to induce information about new examples of familiar categories.
Electron transport and magnetic properties of rare-earth ortho-titanites and -vanadites, LnTiO3 and LnVO3 (1976)

Electron transport and magnetic properties of a number of rare-earth ortho-titanites, LnTiO3 (Ln rare-earth or Y), and ortho-vanadites, LnVO3, are studied in detail. The results are discussed in terms of Goodenough's phenomenological phase diagram. Properties of various transition metal oxide perovskites, LnBO3 (B transition metal), are compared. In einer Reihe von Seltenen-Erd-Ortho-Titaniten, LnTiO3 (Ln Seltene Erde oder Y), und -Ortho-Vanaditen, LnVO3, werden Elektronentransport und magnetische Eigenschaften ausführlich untersucht. Die Ergebnisse werden mit dem phänomenologischen Phasendiagramm von Goodenough diskutiert. Die Eigenschaften der verschiedenen Übergangsmetalloxid-Perovskite, LnBO3 (B Übergangsmetall) werden verglichen.
Targeting aggressive prostate cancer-associated CD44v6 using phage display selected peptides (2017)

There is a crucial need to identify new biomarkers associated with aggressive prostate cancer (PCa) including those associated with cancer stem cells (CSCs). CD44v6, generated by alternative splicing of CD44, has been proposed as a CSC biomarker due to its correlation with aggressive PCa disease. We hypothesized that phage display selected peptides that target CD44v6 may serve as theranostic agents for aggressive PCa. Here, a 15 amino acid peptide ("PFT") was identified by affinity selection against a peptide derived from the v6 region of CD44v6. Synthesized PFT exhibited specific binding to CD44v6 with an equilibrium dissociation constant (Kd) of 743.4 nM. PFT also bound CD44v6 highly expressed on human PCa cell lines. Further, an aggressive form of PCa cells (v6A3) was isolated and tagged by a novel CSC reporter vector. The v6A3 cells had a CSC-like phenotype including enriched CD44v6 expression, enhanced clonogenicity, resistance to chemotherapeutics, and generation of heterogeneous offspring. PFT exhibited preferential binding to v6A3 cells compared to parental cells. Immunohistofluorescence studies with human PCa tissue microarrays (TMA) indicated that PFT was highly accurate in detecting CD44v6-positive aggressive PCa cells, and staining positivity was significantly higher in late stage, metastatic and higher-grade samples. Taken together, this study provides for the first time phage display selected peptides that target CD44v6 overexpressed on PCa cells. Peptide PFT may be explored as an aid in the diagnosis and therapy of advanced PCa disease.
A dual‐gap RGBW transflective TFT‐LCD with adjustable color gamut (2007)

Abstract— An adjustable‐color‐gamut dual‐gap RGBW transflective liquid‐crystal display that uses a four‐color manufacturing process and a color‐processing algorithm to achieve the appropriate color performance in both the transmissive and reflective modes is presented. Based on superior‐color‐transformation units, the total brightness and color gamut can be modified under different ambience. The highest NTSC color gamut in the reflective mode (reflectance, 4.4%) that has been fabricated successfully for a RGBW 1.5‐in. dual‐gap panel is 23% with a 7%, 17%, and 40% NTSC color gamut in the transmissive mode by using different algorithms. Compared to a typical RGB panel, it not only provides flexibility for any environment but also satisfies a variety of personal requirements. Based on personal preference, users have more choices to adjust the LCD settings such as color saturation, brightness, etc. The smart RGBW TRLCD will definitely become the developing trend towards sunlight‐readable LCDs in the near future.
CE Society and the Korean IEIE Society: The Sister Society Update [Society News] (2015)

Reports on the activities of the Korean IEIE Society.
Regulation of Antigen-Specific CD8 <sup>+</sup> T Cell Homeostasis by Perforin and Interferon-γ (2000)

T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules.
Notices Helminthologiques (deuxième série) (1891)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Comparison of Electroanatomic Contact and Noncontact Mapping of Ventricular Scar in a Postinfarct Ovine Model With Intramural Needle Electrode Recording and Histological Validation (2008)

Both the CARTO contact and EnSite noncontact systems were moderately accurate in identifying postinfarct scar when compared with intramural electrodes and confirmed with histology. The EnSite dynamic substrate map was comparable to the CARTO contact bipolar PPV when points >40 mm from the array were excluded.
Novel online profiling for virtual machines (2010)

Application profiling is a popular technique to improve program performance based on its behavior. Offline profiling, although beneficial for several applications, fails in cases where prior program runs may not be feasible, or if changes in input cause the profile to not match the behavior of the actual program run. Managed languages, like Java and C\#, provide a unique opportunity to overcome the drawbacks of offline profiling by generating the profile information online during the current program run. Indeed, online profiling is extensively used in current VMs, especially during selective compilation to improve program startup performance, as well as during other feedback-directed optimizations. In this paper we illustrate the drawbacks of the current reactive mechanism of online profiling during selective compilation. Current VM profiling mechanisms are slow -- thereby delaying associated transformations, and estimate future behavior based on the program's immediate past -- leading to potential misspeculation that limit the benefits of compilation. We show that these drawbacks produce an average performance loss of over 14.5% on our set of benchmark programs, over an ideal offline approach that accurately compiles the hot methods early. We then propose and evaluate the potential of a novel strategy to achieve similar performance benefits with an online profiling approach. Our new online profiling strategy uses early determination of loop iteration bounds to predict future method hotness. We explore and present promising results on the potential, feasibility, and other issues involved for the successful implementation of this approach.
Malignancies in Italian Patients with Systemic Sclerosis Positive for Anti-RNA Polymerase III Antibodies (2011)

In a cohort of Italian patients with SSc we observed a significant association between malignancies synchronous to SSc onset and positivity for anti-RNAP III antibodies, similar to that described in American patients with SSc.
Cellular drug delivery : principles and practice (2004)

Research on cellular drug design and the development of pharmaceutical platforms for the controlled delivery of a drug to its cellular sites of action has dramatically evolved in recent years. In Cellular Drug Delivery: Principles and Practice, established investigators in pharmaceutical research and industry review and summarize the emerging principles and practice of cellular drug delivery. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier systems related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides, as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches. Additional chapters review the fundamental concepts and synthesize our optimal understanding of cellular structure, transport, growth, and defense response, and their roles in cellular drug delivery. Comprehensive and up-to-date, Cellular Drug Delivery: Principles and Practice offers pharmaceutical scientists a uniquely valuable reference resource devoted to illuminating the fundamentals, principles, and practice of cellular drug delivery today
Onset age and severity of motor impairment are associated with reduction of myocardial 123I-MIBG uptake in Parkinson's disease (2003)

This study suggests that late onset, high severity PD is associated with myocardial sympathetic dysfunction.
NMR analysis of lignins in CAD-deficient plants. Part 1. Incorporation of hydroxycinnamaldehydes and hydroxybenzaldehydes into lignins (2002)

Peroxidase/H2O2-mediated radical coupling of 4-hydroxycinnamaldehydes produces 8-O-4-, 8-5-, and 8-8-coupled dehydrodimers as has been documented earlier, as well as the 5-5-coupled dehydrodimer. The 8-5-dehydrodimer is however produced kinetically in its cyclic phenylcoumaran form at neutral pH. Synthetic polymers produced from mixtures of hydroxycinnamaldehydes and normal monolignols provide the next level of complexity. Spectral data from dimers, oligomers, and synthetic polymers have allowed a more substantive assignment of aldehyde components in lignins isolated from a CAD-deficient pine mutant and an antisense-CAD-downregulated transgenic tobacco. CAD-deficient pine lignin shows enhanced levels of the typical benzaldehyde and cinnamaldehyde end-groups, along with evidence for two types of 8-O-4-coupled coniferaldehyde units. The CAD-downregulated tobacco also has higher levels of hydroxycinnamaldehyde and hydroxybenzaldehyde (mainly syringaldehyde) incorporation, but the analogous two types of 8-O-4-coupled products are the dominant features. 8-8-Coupled units are also clearly evident. There is clear evidence for coupling of hydroxycinnamaldehydes to each other and then incorporation into the lignin, as well as for the incorporation of hydroxycinnamaldehyde monomers into the growing lignin polymer. Coniferaldehyde and sinapaldehyde (as well as vanillin and syringaldehyde) co-polymerize with the traditional monolignols into lignins and do so at enhanced levels when CAD-deficiency has an impact on the normal monolignol production. The implication is that, particularly in angiosperms, the aldehydes behave like the traditional monolignols and should probably be regarded as authentic lignin monomers in normal and CAD-deficient plants.
THE LEARNING CURVE: HISTORICAL REVIEW AND COMPREHENSIVE SURVEY (1979)

ABSTRACT The use of the learning curve has been receiving increasing attention in recent years. Much of this increase has been due to learning curve applications other than in the traditional learning curve areas. A comprehensive survey of developments in the learning curve area has never been published. The closest thing to a survey was by Asher in 1956. His study focused exclusively on military applications during and immediately after World War II. This paper summarizes the learning curve literature from World War II to the present, emphasizing developments since the study by Asher. Particular emphasis is given to identifying the new directions into which the learning curve has made recent inroads and identifying fruitful areas for future research.
Analytical and new transmission line equivalent circuit modelling methods for swept frequency of power transformers (1994)

The technique of swept frequency response for condition monitoring of power transformers in-situ provides a non-intrusive means of determining the mechanical integrity of winding systems. The paper describes a new modelling strategy by which the physical dimensions, electromagnetic field distribution, and material properties of the transformer construction are fed into a purpose written program which generates an equivalent circuit model for the windings. The circuit model would be suitable for solution by standard network solvers such as SPICE. A comparison between the measured and calculated results using the newly developed technique for frequency response tests are encouraging.
Nonlinear electrokinetics at large voltages (2009)

The classical theory of electrokinetic phenomena assumes a dilute solution of point-like ions in chemical equilibrium with a surface whose double-layer voltage is of order the thermal voltage, kBT/e=25 mV. In nonlinear 'induced-charge' electrokinetic phenomena, such as ac electro-osmosis, several volts ≈100kBT/e are applied to the double layer, and the theory breaks down and cannot explain many observed features. We argue that, under such a large voltage, counterions 'condense' near the surface, even for dilute bulk solutions. Based on simple models, we predict that the double-layer capacitance decreases and the electro-osmotic mobility saturates at large voltages, due to steric repulsion and increased viscosity of the condensed layer, respectively. The former suffices to explain observed high-frequency flow reversal in ac electro-osmosis; the latter leads to a salt concentration dependence of induced-charge flows comparable to experiments, although a complete theory is still lacking.
The Enumeration and Preservation of Bacteria in Urine (1961)

Journal Article The Enumeration and Preservation of Bacteria in Urine Get access Thomas W. Mou, M.D., Thomas W. Mou, M.D. 1Department of Preventive Medicine, State University of New York, Upstate Medical Center, Syracuse, New York Search for other works by this author on: Oxford Academic Google Scholar Harry A. Feldman, M.D. Harry A. Feldman, M.D. 1Department of Preventive Medicine, State University of New York, Upstate Medical Center, Syracuse, New York Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 35, Issue 6_ts, June 1961, Pages 572–575, https://doi.org/10.1093/ajcp/35.6_ts.572 Published: 01 June 1961 Article history Received: 27 August 1960 Accepted: 02 February 1961 Published: 01 June 1961