gebhart/patrepeval huggingface dataset:
Synthesis, Conjugation, and Radiolabeling of a Novel Bifunctional Chelating Agent for <sup>225</sup>Ac Radioimmunotherapy Applications (2000)

225Ac (t(1/2) = 10 days) is an alternative alpha-emitter that has been proposed for radioimmunotherapy (RIT) due to its many favorable properties, such as half-life and mode of decay. The factor limiting use of (225)Ac in RIT is the lack of an acceptably stable chelate for in vivo applications. Herein is described the first reported bifunctional chelate for (225)Ac that has been evaluated for stability for in vivo applications. The detailed synthesis of a bifunctional chelating agent 2-(4-isothiocyanatobenzyl)-1,4,7,10,13, 16-hexaazacyclohexadecane- 1,4,7,10,13,16-hexaacetic acid (HEHA-NCS) is reported. This ligand was conjugated to three monoclonal antibodies, CC49, T101, and BL-3 with chelate-to-protein ratios between 1.4 and 2. The three conjugates were radiolabeled with (225)Ac, and serum stability study of the [(225)Ac]BL-3-HEHA conjugate was performed.
The radio-frequency emission coefficient of a hot plasma (1964)

In this paper the spectrum of radio-frequency radiation from a fully ionized ion-electron plasma is calculated, starting from the dependence of the dipole moment on the particle-particle Coulomb fields. These Coulomb fields are shielded according to the usual dielectric constant theory. The acceleration of a particle by others of like species gives rise to quadrupole radiation only; thus the second derivative of the dipole moment depends on the sum of ion-electron forces. It is simplest to find the total force acting on each ion due to all the electrons, and then to sum over the ions. Ion-ion correlation may be allowed for readily.
Surface characterization of alumina-supported ceria (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface characterization of alumina-supported ceriaJ. Z. Shyu, W. H. Weber, and H. S. GandhiCite this: J. Phys. Chem. 1988, 92, 17, 4964–4970Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/j100328a029https://doi.org/10.1021/j100328a029research-articleACS PublicationsRequest reuse permissionsArticle Views1995Altmetric-Citations442LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Racial Differences in Biological Sensitivity to Ethanol: The Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes (1981)

Electrophoretic and kinetic studies of autopsy liver specimens from individuals of different racial groups revealed a polymorphism in alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). About 85% of the Japanese livers had an atypical ADH and 52% of the livers an unusual ALDH. Only 13% of German liver specimens had the atypical ADH and none showed the unusual form of ALDH which lacks in the isozyme with low Km for acetaldehyde. Using hair roots as the source of ADH and ALDH, individuals showing sensitivity to ethanol were examined. Data on the distribution of phenotypes in random European and Japanese population as well as family studies suggest a direct relationship between the lack of low Km isozyme of ALDH and alcohol-induced biological sensitivity. Our findings suggest that the alcohol sensitivity quite common in individuals of Mongoloid origin might be due to delayed oxidation of acetaldehyde by an unusual type of ALDH.
Surgical inaccuracy of tumor resection and reconstruction within the pelvis: An experimental study (2008)

4 experienced surgeons did not manage to consistently respect a fixed surgical margin under ideal working conditions. The complex 3-dimensional architecture of the pelvis would mainly explain this inaccuracy. Solutions to this might be to increase the surgical margin or to use computer- and robotic-assisted technologies in pelvic tumor resection. Furthermore, our attempt to evaluate geometry of the pelvic reconstruction using simple parameters was not satisfactory. We believe that there is a need to define new standards of evaluation.
Block Preconditioners Based on Approximate Commutators (2006)

This paper introduces a strategy for automatically generating a block preconditioner for solving the incompressible Navier--Stokes equations. We consider the "pressure convection--diffusion preconditioners" proposed by Kay, Loghin, and Wathen [SIAM J. Sci. Comput., 24 (2002), pp. 237-256] and Silvester, Elman, Kay, and Wathen [J. Comput. Appl. Math., 128 (2001), pp. 261-279]. Numerous theoretical and numerical studies have demonstrated mesh independent convergence on several problems and the overall efficacy of this methodology. A drawback, however, is that it requires the construction of a convection--diffusion operator (denoted $F_p$) projected onto the discrete pressure space. This means that integration of this idea into a code that models incompressible flow requires a sophisticated understanding of the discretization and other implementation issues, something often held only by the developers of the model. As an alternative, we consider automatic ways of computing $F_p$ based on purely algebraic considerations. The new methods are closely related to the "BFBt preconditioner" of Elman [SIAM J. Sci. Comput., 20 (1999), pp. 1299-1316]. We use the fact that the preconditioner is derived from considerations of commutativity between the gradient and convection--diffusion operators, together with methods for computing sparse approximate inverses, to generate the required matrix $F_p$ automatically. We demonstrate that with this strategy the favorable convergence properties of the preconditioning methodology are retained.
2: Final Report on the Safety Assessment of Quaternium-15 (1986)

Quaternium-15 is used as an antimicrobial preservative in cosmetic products at concentration ranges from ≤0.1 to 1%. The cosmeticingredient is not absorbed through human skin in significant amounts. Animal toxicity studies indicate that Quaternium-15 is mildly to moderately toxic depending on animal species, concentration, and route of exposure. Testicular atrophy and decreased spermatogenesis in immature rabbits were reported in one subchronic dermal study. Orally administered Quaternium-15 was teratogenic in rats when given by gavage to pregnant dams in doses ≥25 mg/kg per day. No teratogenic effects were observed at doses of 5 mg/kg per day. Dermally applied Quaternium-15 did not produce maternal toxicity, fetal toxicity, or fetal abnormalities at doses up to and including 500 mg/kg per day. No testicular effects were produced by Quaternium-15 in three subsequent studies on mature rabbits. Quaternium-15 was a moderate skin irritant in test animals at concentrations above 5%. Quaternium-15 was not a significant eye irritant in rabbits. Animal sensitization studies with Quaternium-15 produced conflicting results depending on the test methodologies used. Quaternium-15 does not appear to possess significant mutagenic activity. Primary irritation studies on Quaternium-15 in inert vehicles and formulations indicate that Quaternium-15 is not a primary skin irritant in humans. Quaternium-15 in inert vehicles may be a human sensitizer in some clinical patients. The sensitization potential of the preservative was much less pronounced when cosmetic products were tested on nonclinical subjects. Quaternium-15 may exhibit cross-sensitization with formaldehyde. Quaternium-15 is not a significant photosensitizing agent. Although Quaternium-15 is a potential skin sensitizer, it is concluded that Quaternium-15 is safe as a cosmeticingredient at concentrations not exceeding those presently in use.
Pituitary Stalk Interruption Syndrome: Diagnostic Delay and Sensitivity of the Auxological Criteria of the Growth Hormone Research Society (2011)

In our cohort, the delay for diagnosis of PSIS with GHD was long and could have been reduced by using the GHRS criteria, in particular, height more than 1.5 SDS below the target height. The specificity of such a strategy needs to be tested in healthy populations.
Synthesis of Mesoporous Carbon Foams Templated by Organic Colloids (2002)

Resorcinol/formaldehyde (RF) sols have useful similarities to silica sols in that both are anionic at high pH and capable of hydrogen bonding at low pH. These similarities can be exploited to prepare composite materials analogously to the synthesis of siliceous mesocellular foams (Si-MCFs). Microemulsion-polymerized polystyrene (PS) microspheres were used as templates to produce composite materials with RF polymer. Upon pyrolysis under argon, these PS/RF composites yielded mesoporous carbon foams (C-MCFs) in which the pore size was roughly two-thirds that of the template. Syntheses without the template did not produce mesoporous materials. These C-MCFs can be synthesized quickly and have properties similar to those of carbon aerogels with the same density.
Modeling and analysis of vias in multilayered integrated circuits (1993)

A method for modeling and analyzing vias the multilayered integrated circuits is presented. The model is based on microwave network theory. The whole via structure is divided into cascaded subnetworks, including a vertical via passing through different layers and transitions from the microstrip line and/or striplines to the vertical via. The parameters of each subnetwork are obtained from electromagnetic field analysis. Numerical results in the frequency domain and the time domain are presented. Validation of the model has been carried out by both measurements and finite-difference-time-domain (FDTD) modeling. The results show good agreement with the measurements in the frequency range for which the components of the experimental model are within specification. The time domain simulation results also agree well with the FDTD results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Complete Genome Sequence of a Variant Porcine Epidemic Diarrhea Virus Strain Isolated in Central China (2013)

We report here the complete genome sequence of the porcine epidemic diarrhea virus strain CH/ZMDZY/11 isolated from central China. Our data, together with sequence data of porcine epidemic diarrhea virus (PEDV) isolates from other parts in China, will help to understand better the epidemiology and genetic diversity of PEDV field isolates in China.
Performance of a wideband (3-14 GHz) dual-pol array (2004)

A test array of 25/spl times/25 dual-pol flared dipoles ("bunny-ears") was built and tested. It was designed for 3-14 GHz applications with a low profile (1.2 cm thick). The egg-crate radiating aperture can be integrated with a thin radome and the multi-layer feed to form a load-bearing structure of an airborne platform. The array has an instantaneous bandwidth of 10 GHz, manifested by an impulse response with 100 ps rise time. Smooth well-behaved "active" element patterns in the E-, H-, and diagonal plane were observed. Cross-pol components were typically 30 dB below the co-pol at broadside and 20 dB on average at 60 degree off axis. Element gain over the band was measured and the data tracked fairly well with the theoretical curve defined by the element's unit area gain (4/spl pi/A//spl lambda//sup 2/).
Mitosis-specific phosphorylation of polyomavirus middle-sized tumor antigen and its role during cell transformation. (1993)

Transformation of cells in culture by polyomavirus is mediated by one of its early gene products, middle-sized tumor antigen (MTAg). This protein forms multiple complexes with cellular enzymes such as tyrosine kinases (pp60c-src), a phosphatidylinositol 3-kinase, and phosphatase 2A. Association with MTAg leads to the activation of pp60c-src through interference with phosphorylation at Tyr-527, a site negatively regulating src kinase activity. MTAg abrogates mitosis-specific activation of pp60c-src, resulting in constitutive high kinase activity of the enzyme throughout all phases of the cell cycle. Here we report that MTAg is transiently modified during mitosis, resulting in an increase in its apparent molecular size on SDS/acrylamide gels. Similarly, MTAg isolated from interphase cells and phosphorylated by the cell cycle-regulated serine/threonine kinase p34cdc2 in vitro has increased molecular mass. The large molecular mass form of the protein can be converted to the authentic 56-kDa form upon dephosphorylation by potato acid phosphatase. Two putative phosphorylation sites for a cdc2-like kinase were identified as Thr-160 and -291, respectively. Conversion of Thr-160 to Ala resulted in a transformation-defective mutant protein that was still capable of associating with pp60c-src, phosphatidylinositol 3-kinase, and phosphatase 2A, while the corresponding mutant in position 291 was wild type with respect to all parameters measured so far. These data suggest that phosphorylation by p34cdc2 or a related cell cycle-regulated kinase modulates the interaction of MTAg with cellular targets that are crucial for cell transformation.
Nivolumab: Targeting PD-1 to Bolster Antitumor Immunity (2015)

Nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, blocks PD-1 and can restore anticancer immune responses by abrogating PD-1 pathway-mediated T-cell inhibition. Nivolumab is approved in Japan and the USA for the treatment of patients with advanced melanoma. A Phase I trial reported overall objective response rates of 17, 32 and 29% in patients with advanced non-small-cell lung cancer, melanoma and renal cell carcinoma, respectively, which included many heavily pretreated patients. 1-/2-year overall survival rates were 42%/24%, 63%/48% and 70%/50% for non-small-cell lung cancer, melanoma and renal cell carcinoma, respectively. Nivolumab significantly improved survival versus dacarbazine in previously untreated patients with metastatic melanoma in a Phase III trial. Nivolumab is associated with a manageable adverse event profile. Numerous clinical trials are investigating nivolumab alone or in combination with other therapies in multiple cancer settings. This article summarizes the development of nivolumab as of November 2014.
The relationship of postoperative delirium with psychoactive medications (1994)

<h3>Objective.</h3> —To examine the role of medications with known psychoactive properties in the development of postoperative delirium. <h3>Design.</h3> —Nested case-control study within a prospective cohort study. <h3>Setting.</h3> —General surgery, orthopedic surgery, and gynecology services at Brigham and Women's Hospital, Boston, Mass. <h3>Patients.</h3> —Cases (n=91) were patients enrolled in a prospective cohort study who developed delirium during postoperative days 2 through 5. One or two controls (n=154) were matched to each case by the calculated preoperative risk for delirium using a predictive model developed and validated in the prospective cohort study. <h3>Main Outcome Measures.</h3> —Medication exposures were ascertained from the medical record by a reviewer blinded to the study hypothesis. Exposures to narcotics, benzodiazepines, and anticholinergics were recorded for the 24-hour period before delirium developed in the 91 cases and for the same 24-hour postoperative period for the 154 matched controls. <h3>Results.</h3> —Delirium was significantly associated with postoperative exposure to meperidine (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.3 to 5.5) and to benzodiazepines (OR, 3.0; 95% CI, 1.3 to 6.8). Meperidine had similar associations with delirium whether administered via epidural or patient-controlled routes, although only the epidural route reached significance (OR, 2.4; 95% CI, 1.3 to 4.4; OR, 2.1; 95% CI, 0.4 to 10.7, respectively). For benzodiazepines, long-acting agents had a trend toward stronger association with delirium than did short-acting agents (OR, 5.4; 95% CI, 1.0 to 29.2; vs 2.6; 1.1 to 6.5), and high-dose exposures had a trend toward slightly stronger association than low-dose exposures (OR, 3.3; 95% CI, 1.0 to 11.0; vs 2.6; 0.8 to 9.1). Neither narcotics (OR, 1.4; 95% CI, 0.5 to 4.3) nor anticholinergic drugs (OR, 1.5; 95% CI, 0.6 to 3.4) were significantly associated with delirium as a class, although statistical power was limited because of the high use of narcotics and the low use of anticholinergics in the study population. <h3>Conclusions.</h3> —Clinicians caring for patients at risk for delirium should carefully evaluate the need for meperidine and benzodiazepines in the postoperative period and consider alternative therapies whenever possible. (<i>JAMA</i>. 1994;272:1518-1522)
Binary moving-blocker-based scatter correction in cone-beam computed tomography with width-truncated projections: proof of concept (2017)

This paper proposes a binary moving-blocker (BMB)-based technique for scatter correction in cone-beam computed tomography (CBCT). In concept, a beam blocker consisting of lead strips, mounted in front of the x-ray tube, moves rapidly in and out of the beam during a single gantry rotation. The projections are acquired in alternating phases of blocked and unblocked cone beams, where the blocked phase results in a stripe pattern in the width direction. To derive the scatter map from the blocked projections, 1D B-Spline interpolation/extrapolation is applied by using the detected information in the shaded regions. The scatter map of the unblocked projections is corrected by averaging two scatter maps that correspond to their adjacent blocked projections. The scatter-corrected projections are obtained by subtracting the corresponding scatter maps from the projection data and are utilized to generate the CBCT image by a compressed-sensing (CS)-based iterative reconstruction algorithm. Catphan504 and pelvis phantoms were used to evaluate the method's performance. The proposed BMB-based technique provided an effective method to enhance the image quality by suppressing scatter-induced artifacts, such as ring artifacts around the bowtie area. Compared to CBCT without a blocker, the spatial nonuniformity was reduced from 9.1% to 3.1%. The root-mean-square error of the CT numbers in the regions of interest (ROIs) was reduced from 30.2 HU to 3.8 HU. In addition to high resolution, comparable to that of the benchmark image, the CS-based reconstruction also led to a better contrast-to-noise ratio in seven ROIs. The proposed technique enables complete scatter-corrected CBCT imaging with width-truncated projections and allows reducing the acquisition time to approximately half. This work may have significant implications for image-guided or adaptive radiation therapy, where CBCT is often used.
Release of Ethanolamine Pyrophosphate during Mild Acid Hydrolysis of the Lipopolysaccharide of <i>Pseudomonas aeruginosa</i> (1971)

Low molecular weight solutes released during mild acid hydrolysis of the lipopolysaccharide of Pseudomonas aeruginosa were isolated from the fraction containing the partially degraded polysaccharide, by successive chromatography on columns of Sephadex G‐75 and G‐10, followed (as necessary) by preparative high voltage paper electrophoresis. The major components identified were 2‐keto‐3‐deoxyoctonic acid, basic amino acids (free and bound), inorganic orthophosphate, ethanolamine phosphate and ethanolamine pyrophosphate. Ethanolamine pyrophosphate has not previously been found in acid hydrolysates of lipopolysaccharides. Ethanolamine phosphate and some of the orthophosphate were apparently produced by breakdown of ethanolamine pyrophosphate.
Biomolecular interaction analysis technique and its applications in life science (2006)

Biomolecular active function is realized by the interaction of molecules.Detection and study of the biomolecular interaction process are of great importance in revealing the fundamental mechanisms of life occurrence and development.Biomolecular interaction analysis technique which is based on surface plasmon resonance has been an ideal tool in studying the biomolecular interaction.It can detect the whole process of biomolecules association and dissociation in real time and has a broad variety of applications and exciting future in proteomics,signal transduction,drug discovery,genetics and food analysis etc.
Enthalpy of Mixing of Liquid Cu-Ni-Si Alloys (2000)

A thermodynamic description of the Cr-Ti system is obtained by the optimization of the available thermodynamic and phase diagram data. The Redlich-Kister polynomial is used to describe the excess Gibbs energies of the liquid, bcc and hcp phases. The sublattice model is used to describe the different types of Cr 2 Ti Lives phases. The α-Cr 2 Ti phase is described with two sublattices after the formula (Cr,Ti) 2 (Ti,Cr) 1 . The β-Cr 2 Ti and γ-Cr 2 Ti phase are described with three sublattices after the formula (Cr) 2 (Ti,Cr) 4 (Cr,Ti) 6 . Calculated phase diagram and thermodynamic data show good agreement with the experimental data.
A Frequency-Stabilized Microwave Band-Rejection Filter Using High Dielectric Constant Resonators (1969)

The high permittivity dielectric resonator is a low loss microwave filter element whose size is substantiality less than metal waveguide cavities. Temperature stabilizing their resonant frequency increases the applicability of such elements. A temperature compensated 3-section band-rejection filter using dielectric resonators has been fabricated and tested. The measured electrical performance was comparable to metal waveguide filters and the frequency stability for temperature variations was comparable to brass waveguide cavity filters which are not temperature compensated.