gebhart/patrepeval huggingface dataset:
Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of <i>Pseudomonas aeruginosa</i> (2005)

One of the mechanisms contributing to the protection by breast-feeding of the newborn against enteric diseases is related to the ability of human milk oligosaccharides to prevent the attachment of pathogenic bacteria to the duodenual epithelium. Indeed, a variety of fucosylated oligosaccharides, specific to human milk, form part of the innate immune system. In the present study, we demonstrate the specific blocking of PA-IIL, a fucose-binding lectin of the human pathogen Pseudomonas aeruginosa, by milk oligosaccharides. Two fucosylated epitopes, Lewis a and 3-fucosyl-lactose (Lewis x glucose analogue) bind to the lectin with dissociation constants of 2.2×10−7 M and 3.6×10−7 M respectively. Thermodynamic studies indicate that these interactions are dominated by enthalpy. The entropy contribution is slightly favourable when binding to fucose and to the highest-affinity ligand, Lewis a. The high-resolution X-ray structures of two complexes of PA-IIL with milk oligosaccharides allow the precise determination of the conformation of a trisaccharide and a pentasaccharide. The different types of interaction between the oligosaccharides and the protein involve not only hydrogen bonding, but also calcium- and water-bridged contacts, allowing a rationalization of the thermodynamic data. This study provides important structural information about compounds that could be of general application in new therapeutic strategies against bacterial infections.
High-power high-speed photodetectors-design, analysis, and experimental demonstration (1997)

A novel velocity-matched distributed photodetector (VMDP) is proposed to simultaneously achieve high saturation photocurrent and broad bandwidth. Theoretical analysis on the tradeoff between saturation power and bandwidth shows that the VMDP offers fundamental advantages over conventional photodetectors. A comprehensive theoretical model has been developed for the design and simulation of the VMDP. Experimentally, the VMDP with very high saturation (56-mA) photocurrent and instrument-limited 3-dB bandwidth (49 GHz) has been demonstrated. The theoretical analysis and experimental results show that the VMDP is very attractive for high-performance microwave photonic links and high-power optical microwave applications.
Stereoselective synthesis of conjugated trans-enynes readily convertible into conjugated cis,trans-dienes and its application to the synthesis of the pheromone bombykol (1973)

Treatment of the borate complexes derived from bis-(1,2-dimethylpropyl)alkenylboranes and alkynyl-lithiums with iodine and sodium hydroxide produces in a highly stereoselective (> 99%) manner conjugated trans-enynes readily convertible into the corresponding cis,trans-dienes.
The customised electronic nebuliser: a new category of liquid aerosol drug delivery systems (2005)

Inhalation of aerosols is the preferred route of administration of pharmaceutical compounds to the lungs when treating various respiratory diseases. Inhaled antibiotics, hormones, peptides and proteins are potential candidates for direct targeting to the site of action, thus minimising systemic absorption, dilution and undesired side effects, as much lower doses (as low as a fiftieth) are sufficient to achieve a similar therapeutic effect, compared with oral administration. A quick relief from the symptoms and a good tolerance are the main advantages of aerosol therapy. A new class of electronic delivery device is now starting to enter the market. The eFlow electronic nebuliser (PARI GmbH, Germany) provides improved portability and, in some instances, cuts treatment time to only a fraction of what has been experienced with current nebulised therapy. Drug formulations and the device can be mutually adapted and matched for optimal characteristics to meet the desired therapeutic target. Reformulation of known and proven compounds in a liquid format are commercially attractive as they present a relatively low development risk for potential drug candidates and, thus, have become a preferred pathway for the development of new inhalation products.
Optimizing Call Center Staffing Using Simulation and Analytic Center Cutting-Plane Methods (2007)

We consider the problem of minimizing staffing costs in an inbound call center, while maintaining an acceptable level of service in multiple time periods. The problem is complicated by the fact that staffing level in one time period can affect the service levels in subsequent periods. Moreover, staff schedules typically take the form of shifts covering several periods. Interactions between staffing levels in different time periods, as well as the impact of shift requirements on the staffing levels and cost, should be considered in the planning. Traditional staffing methods based on stationary queueing formulas do not take this into account. We present a simulation-based analytic center cutting-plane method to solve a sample average approximation of the problem. We establish convergence of the method when the service-level functions are discrete pseudoconcave. An extensive numerical study of a moderately large call center shows that the method is robust and, in most of the test cases, outperforms traditional staffing heuristics that are based on analytical queueing methods.
Spin coherence excitation and rephasing with optically shelved atoms (1998)

We investigate the use of resonant optical Raman pulses to excite and rephase ground state spin coherences via the partial storage or shelving of atoms. Unlike direct-rf-excited spin echoes or off-resonant Raman echoes, the resonant Raman optical field efficiently excites and rephases the spin coherence using \ensuremath{\pi} and 2\ensuremath{\pi} pulses, respectively. In a crystal of ${\mathrm{Pr}}^{3+}$ doped ${\mathrm{Y}}_{2}{\mathrm{SiO}}_{5},$ we experimentally observe spin echo efficiency as high as 46% of the free induction decay signal.
Supplementing fibroblast growth factor 2 during bovine oocyte &lt;i&gt;in vitro&lt;/i&gt; maturation promotes subsequent embryonic development (2012)

The Spontaneously Diabetic Torii (SDT) rat is a novel model for nonobese type 2 diabetes. In this study we investigated the glycolipid metabolic changes with phlorizin-treatment, which inhibits intestinal glucose uptake and renal glucose reabsorption, in male SDT rats. Phlorizin (100 mg/kg, b.i.d., s.c.) was administered for 4 weeks to SDT rats from 20 to 24 weeks of age. As a result, phlorizin reduced the development of hyperglycemia and decreased the hemoglo-bin A1c (HbA1c) levels. In the liver, phlorizin increased mRNA levels of glucokinase, the enzymes related with the glycogen cascade and the proteins associated with lipid metabolism. In conclusion, chronic administration of phlorizin in SDT rats produced a good glycemic control and an improvement in liver function.
The Nc1/Endostatin Domain of<i>Caenorhabditis elegans</i>Type Xviii Collagen Affects Cell Migration and Axon Guidance (2001)

Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function, whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent. The Caenorhabditis elegans collagen XVIII homologue, cle-1, encodes three developmentally regulated protein isoforms expressed predominantly in neurons. The CLE-1 protein is found in low amounts in all basement membranes but accumulates at high levels in the nervous system. Deletion of the cle-1 NC1 domain results in viable fertile animals that display multiple cell migration and axon guidance defects. Particular defects can be rescued by ectopic expression of the NC1 domain, which is shown to be capable of forming trimers. In contrast, expression of monomeric ES does not rescue but dominantly causes cell and axon migration defects that phenocopy the NC1 deletion, suggesting that ES inhibits the promigratory activity of the NC1 domain. These results indicate that the cle-1 NC1/ES domain regulates cell and axon migrations in C. elegans.
Chaser (Csr), a new gene affecting larval foraging behavior in Drosophila melanogaster. (1995)

Chaser (Csr) was uncovered in a gamma mutagenesis screen to identify genes that modify the larval foraging behavior of sitters to rovers. Rover larvae have significantly longer path lengths than sitters while foraging on a yeast and water paste. This difference is influenced by one major gene, foraging (for), which has two naturally occurring alleles, forR (rover) and fors (sitter). In a mutagenesis screen for modifiers of for, we identified three lines with viable mutations on chromosome 3 that alter foraging behavior. Each of these mutations increased larval path lengths in fors/fors larvae in a dominant fashion, and were not separable by recombination. These mutations are therefore probably allelic and define a new gene that we have called Csr. Csr was genetically localized using the lethal-tagging technique. This technique resulted in seven lines with a significant decrease in larval path-length and recessive lethal mutations on chromosome 3. We refer to these as reverted Csr (Csrrv) lines. Deficiencies that uncovered cytologically visible chromosome rearrangements in three of the seven reverted lines were used in a complementation analysis. In this way we mapped the lethal mutations in the Csrrv lines to cytological region 95F7-96A1 on the right arm of chromosome 3.
Weighted Low-Rank Approximation of Matrices and Background Modeling (2018)

We primarily study a special a weighted low-rank approximation of matrices and then apply it to solve the background modeling problem. We propose two algorithms for this purpose: one operates in the batch mode on the entire data and the other one operates in the batch-incremental mode on the data and naturally captures more background variations and computationally more effective. Moreover, we propose a robust technique that learns the background frame indices from the data and does not require any training frames. We demonstrate through extensive experiments that by inserting a simple weight in the Frobenius norm, it can be made robust to the outliers similar to the $\ell_1$ norm. Our methods match or outperform several state-of-the-art online and batch background modeling methods in virtually all quantitative and qualitative measures.
Delayed-dictionary compression for packet networks (2005)

This paper considers compression in packet networks. Since data packets may be dropped or arrive reordered, streaming compression algorithms result in a considerable decoding latency. On the other hand, standard stateless packet compression algorithms that compress each packet independently, give a relatively poor compression ratio. We introduce a novel compression algorithm for packet networks: delayed-dictionary compression. By allowing delay in the dictionary construction, the algorithm handles effectively the problems of packet drops and packet reordering, while resulting with a compression quality which is often substantially better than standard stateless packet compression and has a smaller decoding latency than that of streaming compression. We conducted extensive experiments to establish the potential improvement for packet compression techniques, using many data files including the Calgary corpus and the Canterbury corpus. Experimental results of the new delayed-dictionary compression show that its main advantage is in low to medium speed links.
Prevention of Type I Diabetes and Recurrent β-Cell Destruction of Transplanted Islets* (1997)

I. Introduction II. Disease Pathogenesis III. Disease Prediction A. Genetic prediction B. Immunological prediction C. Metabolic prediction IV. Prevention of Type I Diabetes A. Trial design B. Genetic prevention C. Prevention: preautoimmunity D. Prevention: postautoimmunity/prediabetes E. New onset patients/prevention of further β-cell destruction F. Pancreas and islet cell transplantation/prevention of recurrent diabetes G. Islet cell transplantation/prevention of β-cell destruction V. Conclusion
Communication Channels and Word of Mouth: How the Medium Shapes the Message (2013)

Consumers share word of mouth face to face, over social media, and through a host of other communication channels. But do these channels affect what people talk about and, if so, how? Laboratory experiments, as well as analysis of almost 20, 000 everyday conversations, demonstrate that communicating via oral versus written communication affects the products and brands consumers discuss. Compared to oral communication, written communication leads people to mention more interesting products and brands. Further, this effect is driven by communication asynchrony and self-enhancement concerns. Written communication gives people more time to construct and refine what to say, and self-enhancement motives lead people to use this opportunity to mention more interesting things. These findings shed light on how communication channels shape interpersonal communication and the psychological drivers of word of mouth more broadly.
Idiopathic Macular Telangiectasia Type 2: The Progressive Vasculopathy (2012)

Purpose. To describe the complete sequence of the progressive vasculopathy in macular telangiectasia type 2. Methods. This is a report of a case demonstrating the complete vasogenic sequence in macular telangiectasia type 2 over the course of 15 years, and representative images from a collective of 150 patients with macular telangiectasia type 2 employing fundus photography, fluorescein angiography, and optical coherence tomography. Results. Macular telangiectasia may progress along a predictable vasogenic sequence which consists of nonproliferative stages, characterized by temporal loss of macular luteopigment and inner retinal volume loss in the absence of vascular changes, followed by a progressive proliferative vasculopathy, first involving the deep capillary plexus with eventual extension of the vascular changes circumferentially in the inner retinal capillary plexus. Late proliferative stages may become indistinguishable from advanced neovascular age-related macular degeneration. Conclusions. While it is rare to observe the complete vasogenic sequence of macular telangiectasia type 2, a classification into nonproliferative and proliferative stages can be established, and may prove helpful as the mechanisms driving the pathogenic process through those stages are identified.
Transmission diffraction gratings composed of one material with anomalous dispersion in the visible region (1988)

Relief diffraction gratings were produced holographically in Shipley photoresist and castings of these gratings molded in an epoxy resin. The diffraction efficiencies of the epoxy resin gratings were measured when the medium on the opposite side of the relief profile was, respectively, air, water, carbon disulfide-benzene mixtures, and solid nitrosodimethylaniline. Fair agreement was obtained with theory; the large dispersion of the aniline-filled grating resulted in a novel-type grating device having a large diffraction efficiency in the green and a small efficiency elsewhere in the spectrum.
Development of Black Soldier Fly (Diptera: Stratiomyidae) Larvae Fed Dairy Manure (2008)

Black soldier flies, Hermetia illucens L., are a common colonizer of animal wastes. However, all published development data for this species are from studies using artificial diets. This study represents the first examining black soldier fly development on animal wastes. Additionally, this study examined the ability of black soldier fly larvae to reduce dry matter and associated nutrients in manure. Black soldier fly larvae were fed four rates of dairy manure to determine their effects on larval and adult life history traits. Feed rate affected larval and adult development. Those fed less ration daily weighed less than those fed a greater ration. Additionally, larvae provided the least amount of dairy manure took longer to develop to the prepupal stage; however, they needed less time to reach the adult stage. Adults resulting from larvae provided 27 g dairy manure/d lived 3-4 d less than those fed 70 g dairy manure. Percentage survivorship to the prepupal or adult stages did not differ across treatments. Larvae fed 27 g dairy manure daily reduced manure dry matter mass by 58%, whereas those fed 70 g daily reduced dry matter 33%. Black soldier fly larvae were able to reduce available P by 61-70% and N by 30-50% across treatments. Based on results from this study, the black soldier fly could be used to reduce wastes and associated nutrients in confined bovine facilities.
Renewal of alveolar epithelium in the rat following exposure to NO2. (1973)

This research was undertaken to study the kinetics of Type 2 cell division and the fate of the Type 2 sister cell following exposure to NO(2). To accomplish this, male rats were exposed to NO(2). Dividing cells were labeled with (3)H-TdR and studied with autoradiographic technics in the light and electron microscopes for up to 72 hours after labeling. The kinetics of cell division were determined from a curve constructed from the percent of labeled mitotic figures. The fate of the Type 2 sister cells was determined by studying tissues at 24, 48 and 72 hours after labeling with (3)H-TdR. The results show that Type 2 cells may divide and the sister cells transform into Type 1 cells. These data support an interpretation of the mechanism for cell renewal of the alveolar epithelium in which Type 2 cells are the progenitor cells for Type 1 cells.
Learning to Resolve Natural Language Ambiguities: A Unified Approach (1998)

We analyze a few of the commonly used statistics based and machine learning algorithms for natural language disambiguation tasks and observe that they can be re-cast as learning linear separators in the feature space. Each of the methods makes a priori assumptions, which it employs, given the data, when searching for its hypothesis. Nevertheless, as we show, it searches a space that is as rich as the space of all linear separators. We use this to build an argument for a data driven approach which merely searches for a good linear separator in the feature space, without further assumptions on the domain or a specific problem. We present such an approach - a sparse network of linear separators, utilizing the Winnow learning algorithm - and show how to use it in a variety of ambiguity resolution problems. The learning approach presented is attribute-efficient and, therefore, appropriate for domains having very large number of attributes. In particular, we present an extensive experimental comparison of our approach with other methods on several well studied lexical disambiguation tasks such as context-sensitive spelling correction, prepositional phrase attachment and part of speech tagging. In all cases we show that our approach either outperforms other methods tried for these tasks or performs comparably to the best.
Co-array Fortran for parallel programming (1998)

Co-Array Fortran, formerly known as F -- , is a small extension of Fortran 95 for parallel processing. A Co-Array Fortran program is interpreted as if it were replicated a number of times and all copies were executed asynchronously. Each copy has its own set of data objects and is termed an image. The array syntax of Fortran 95 is extended with additional trailing subscripts in square brackets to give a clear and straightforward representation of any access to data that is spread across images.References without square brackets are to local data, so code that can run independently is uncluttered. Only where there are square brackets, or where there is a procedure call and the procedure contains square brackets, is communication between images involved.There are intrinsic procedures to synchronize images, return the number of images, and return the index of the current image.We introduce the extension; give examples to illustrate how clear, powerful, and flexible it can be; and provide a technical definition.
Feedback Control-Based Navigation of a Flying Insect-Machine Hybrid Robot (2018)

This study reports the first ever demonstration of the aero navigation of a free-flying insect based on feedback control. Instead of imitating the complicated kinetics and mechanisms of insect locomotion, a live insect can be directly transformed into a soft robot by embedding it with artificial devices. Since many insects can perform acrobatics aerially, thereby exhibiting far greater flexibility than current man-made flyers, correctly commanding the internal structures of an insect to perform based on the instructions would be a breakthrough. Herein, beetles (Mecynorrhina torquata) were chosen as the flying platform, and an inertial measurement unit-implemented electronic backpack was designed and manufactured to remotely command the beetles. To achieve horizontal flight control, multiple flight muscles of the beetles, that is, the basalar and third axillary muscles were stimulated to control the flight directions. However, the beetles were found to gradually adapt to the electrical stimulation, and the flight corrections were elicited by generating compensatory flight forces during a long-lasting stimulation (>300 ms), which were revealed by the decrease in induced lateral force. Based on this finding, a proportional derivative feedback controller was designed to navigate the flying beetles based on the predetermined path using frequency-dependent electrical pulses. To avoid a continuous stimulation, we proposed a stimulation protocol which separated two stimulations with a 50-ms rest. Compared to long stimulations (>300 ms), a 150-ms stimulation with 200-ms update interval was more efficient in correcting the flight direction of the beetles.
Influence of the number of motile spermatozoa inseminated and of their morphology on the success of intrauterine insemination (2004)

Our results show that a minimum of 5 x 10(6) motile spermatozoa should be inseminated when the normal morphology of the sperm after preparation is < 30%; the quantity compensates at least in part for the defective quality. If this threshold of NMSI cannot be obtained, IVF should be recommended.
Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair (2019)

Extracellular matrix (ECM) hydrogels, produced by tissue decellularization are natural injectable materials suitable for neural tissue repair. However, the rapid biodegradation of these materials may disrupt neural tissue reconstruction in vivo. The aim of this study was to improve the stability of the previously described ECM hydrogel derived from human umbilical cord using genipin and N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC), crosslinking at concentration of 0.5-10 mM. The hydrogels, crosslinked by genipin (ECM/G) or EDC (ECM/D), were evaluated in vitro in terms of their mechanical properties, degradation stability and biocompatibility. ECM/G, unlike ECM/D, crosslinked hydrogels revealed improved rheological properties when compared to uncrosslinked ECM. Both ECM/G and ECM/D slowed down the gelation time and increased the resistance against in vitro enzymatic degradation, while genipin crosslinking was more effective than EDC. Crosslinkers concentration of 1 mM enhanced the in vitro bio-stability of both ECM/G and ECM/D without affecting mesenchymal stem cell proliferation, axonal sprouting or neural stem cell growth and differentiation. Moreover, when injected into cortical photochemical lesion, genipin allowed in situ gelation and improved the retention of ECM for up to 2 weeks without any adverse tissue response or enhanced inflammatory reaction. In summary, we demonstrated that genipin, rather than EDC, improved the bio-stability of injectable ECM hydrogel in biocompatible concentration, and that ECM/G has potential as a scaffold for neural tissue application.