gebhart/patrepeval huggingface dataset:
Reliable clinical monitoring using wireless sensor networks (2010)

This paper presents the design, deployment, and empirical study of a wireless clinical monitoring system that collects pulse and oxygen saturation readings from patients. The primary contribution of this paper is an in-depth clinical trial that assesses the feasibility of wireless sensor networks for patient monitoring in general hospital units. We present a detailed analysis of the system reliability from a long term hospital deployment over seven months involving 41 patients in a step-down cardiology unit. The network achieved high reliability (median 99.68%, range 95.21% -- 100%). The overall reliability of the system was dominated by sensing reliability of the pulse oximeters (median 80.85%, range 0.46% -- 97.69%). Sensing failures usually occurred in short bursts, although longer periods were also present due to sensor disconnections. We show that the sensing reliability could be significantly improved through oversampling and by implementing a disconnection alarm system that incurs minimal intervention cost. A retrospective data analysis indicated that the system provided sufficient temporal resolution to support the detection of clinical deterioration in three patients who suffered from significant clinical events including transfer to Intensive Care Units. These results indicate the feasibility and promise of using wireless sensor networks for continuous patient monitoring and clinical deterioration detection in general hospital units.
Spontaneous Atopic Dermatitis-Like Symptoms in a/a ma ft/ma ft/J Flaky Tail Mice Appear Early after Birth (2013)

Loss-of-function mutations in human profilaggrin gene have been identified as the cause of ichthyosis vulgaris (IV), and as a major predisposition factor for atopic dermatitis (AD). Similarly, flaky tail (a/a ma ft/ma ft/J) mice were described as a model for IV, and shown to be predisposed to eczema. The aim of this study was to correlate the flaky tail mouse phenotype with human IV and AD, in order to dissect early molecular events leading to atopic dermatitis in mice and men, suffering from filaggrin deficiency. Thus, 5-days old flaky tail pups were analyzed histologically, expression of cytokines was measured in skin and signaling pathways were investigated by protein analysis. Human biopsies of IV and AD patients were analyzed histologically and by real time PCR assays. Our data show acanthosis and hyperproliferation in flaky tail epidermis, associated with increased IL1β and thymic stromal lymphopoietin (TSLP) expression, and Th2-polarization. Consequently, NFκB and Stat pathways were activated, and IL6 mRNA levels were increased. Further, quantitative analysis of late epidermal differentiation markers revealed increased Small proline-rich protein 2A (Sprr2a) synthesis. Th2-polarization and Sprr2a increase may result from high TSLP expression, as shown after analysis of 5-days old K14-TSLP tg mouse skin biopsies. Our findings in the flaky tail mouse correlate with data obtained from patient biopsies of AD, but not IV. We propose that proinflammatory cytokines are responsible for acanthosis in flaky tail epidermis, and together with the Th2-derived cytokines lead to morphological changes. Accordingly, the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency.
Performance Evaluation of Reliability Improvement Techniques for Single-Loop Communications Systems (1974)

One of the basic terminal-attachment configurations is the loop. As such, it is receiving substantial attention. But it has been pointed out that loop communication networks are relatively vulnerable and unreliable. This paper considers the single-loop reliability problem. Three loop reliability (availability) improvement techniques are investigated in detail. All three techniques are based on using an auxilliary transmission path parallel to the main loop. A comparative study shows the best techniques.
Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα (2009)

We have demonstrated that ERbeta5 protein is expressed in stage 1 endometrial adenocarcinomas. Expression of three ERbeta variants, including the full-length protein is not grade-dependent and most cells in poorly differentiated cancers are ERbetapos/ERalphaneg. We found evidence of a link between COX-2, its product PGF2alpha, and expression of ERalpha and PR that sheds new light on the cross talk between steroid and PG signalling pathways in this disease.
Synthesis and Characterization of Poly[(R,S)-3-hydroxybutyrate-b-6-hydroxyhexanoate] as a Compatibilizer for a Biodegradable Blend of Poly[(R)-3-hydroxybutyrate] and Poly(6-hydroxyhexanoate) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of Poly[(R,S)-3-hydroxybutyrate-b-6-hydroxyhexanoate] as a Compatibilizer for a Biodegradable Blend of Poly[(R)-3-hydroxybutyrate] and Poly(6-hydroxyhexanoate)Hideki Abe, Yoshiharu Doi, and Yoshiharu KumagaiCite this: Macromolecules 1994, 27, 21, 6012–6017Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://doi.org/10.1021/ma00099a012Request reuse permissionsArticle Views293Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
The Savage Other: “Indianizing” and Performance in Nineteenth-Century American Culture (2007)

In 1993, Jeffrey D. Mason and J. Ellen Gainor began the editorial process that eventuated in the publication of Performing America: Cultural Nationalism in American Theater (1999).1 Slightly more than a decade later, William Demastes invited the editors and authors of the articles that volume contained to again consider the subject of "performing America" for the joint American Theatre and Drama Society-University of Kansas Conference, "Writing, Teaching, Performing America" (in Lawrence, March 2005). Those presentations, in turn, stimulated further consideration of "America" and "Americanness" by these and other scholars, which have eventuated in the present collection, Interrogating America through Theatre and Performance.KeywordsNineteenth CenturyAmerican HistoryAmerican AnthropologyAmerican TheatreCultural NationalismThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi. (1999)

Eighteen human congenital melanocytic naevi (CMN) from 17 patients were screened for activating point mutations in the oncogenes N-ras and CDK4 and for sequence variants in the MC1R gene by combined RFLP-PCR/SSCP analysis. In addition, all lesions were screened for deletions and point mutations in the tumour suppressor genes p53 and p16INK4a (CDKN2A) by combined multiplex PCR/SSCP analysis. Positive screening data were specified by sequencing of the corresponding PCR product. Activating point mutations in the N-ras gene (nine CAA (Gln) to AAA (Lys) transversions and one CAA (Gln) to CGA (Arg) transition at codon 61) were detected at high frequency (56%). Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in the MC1R and p53 genes, respectively. No mutations were found in p16 or CDK4. The activated N-ras oncogene, which is also found in human cutaneous melanomas, may constitute a potential risk factor for melanoma formation within CMN.
CHARMM-GUI ligand reader and modeler for CHARMM force field generation of small molecules (2017)

Reading ligand structures into any simulation program is often nontrivial and time consuming, especially when the force field parameters and/or structure files of the corresponding molecules are not available. To address this problem, we have developed Ligand Reader & Modeler in CHARMM-GUI. Users can upload ligand structure information in various forms (using PDB ID, ligand ID, SMILES, MOL/MOL2/SDF file, or PDB/mmCIF file), and the uploaded structure is displayed on a sketchpad for verification and further modification. Based on the displayed structure, Ligand Reader & Modeler generates the ligand force field parameters and necessary structure files by searching for the ligand in the CHARMM force field library or using the CHARMM general force field (CGenFF). In addition, users can define chemical substitution sites and draw substituents in each site on the sketchpad to generate a set of combinatorial structure files and corresponding force field parameters for throughput or alchemical free energy simulations. Finally, the output from Ligand Reader & Modeler can be used in other CHARMM-GUI modules to build a protein-ligand simulation system for all supported simulation programs, such as CHARMM, NAMD, GROMACS, AMBER, GENESIS, LAMMPS, Desmond, OpenMM, and CHARMM/OpenMM. Ligand Reader & Modeler is available as a functional module of CHARMM-GUI at http://www.charmm-gui.org/input/ligandrm. © 2017 Wiley Periodicals, Inc.
Benefit of in‐phase chest wall vibration on the pulmonary hemodynamics in patients with chronic obstructive pulmonary disease (1998)

IPV improves gas exchange and pulmonary circulation without affecting systemic circulation.
Table-Lookup Methods for Generating Arbitrary Random Numbers (1977)

Extremely fast table-lookup procedures are described for generating random numbers from an arbitrary distribution on a digital computer. The procedures sacrifice some accuracy in order to achieve this speed, but the accuracy is sufficient for most types of Monte-Carlo simulations. A method is given to eliminate the error associated with truncation for distribution functions with an infinite domain. The performance of the table-lookup methods is examined for a few common distribution functions.
An overview of advanced processing techniques for RCS measurements (2002)

For the last ten years, VSD (formerly ERIM International) has had the opportunity to work with several government and industry RCS ranges to develop an intimate understanding of the errors that can occur in making RCS measurements of today's sophisticated targets. This has led to the successful development and demonstration of a variety of advanced processing techniques (APTs) to improve the quality and utility of both indoor and outdoor RCS/ISAR data. These include algorithms for removal of clutter, RFI, and target-support contamination (including interactions), prediction of far field RCS from near field measurements, suppression of multipath contamination, and extraction of scattering features. Several of these are summarized in a table. A discussion and examples of each are also provided.
Recognition Profile of Emotions in Natural and Virtual Faces (2008)

Virtual and natural facial displays of emotion may be equally effective. Improved technology (e.g. better modelling of the naso-labial area) may lead to even better results as compared to trained actors. Due to the ease with which virtual human faces can be animated and manipulated, validated artificial emotional expressions will be of major relevance in future research and therapeutic applications.
<i>In vitro</i>investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on<i>Candida albicans</i> (2006)

Rilopirox and piroctone belong to the class of hydroxypyridone antimycotics. This class is not related to other antimycotics. In contrast to azole antimycotics and polyene antimycotics the mode of action of hydroxypyridone antimycotics is not fully understood. Inhibition of cellular uptake of essential compounds as well as loss of other compounds seems to be only a secondary effect of a primary not known action of these drugs. The antifungal effect in vitro depends on the medium used. The hyphal induction of Candida albicans is inhibited by hydroxypyridone antimycotics, but this effect is compensated by iron ions. A damage of the cell membrane and a direct influence on adenosine triphosphate synthesis, respectively, do not seem to be part of the mode of action. But there are clear hints that reactive oxygen species (ROS) and available metabolic activity are important parts of the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone.
Mass Spectrometry in Structural and Sterochemical Probelms. L.<sup>1</sup> Fragmentation and Hydrogen Migration Reactions of α,β-Unsaturated 3-Keto Steroids<sup>2</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass Spectrometry in Structural and Sterochemical Probelms. L.1 Fragmentation and Hydrogen Migration Reactions of α,β-Unsaturated 3-Keto Steroids2Robert H. Shapiro and Carl. DjerassiCite this: J. Am. Chem. Soc. 1964, 86, 14, 2825–2832Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/ja01068a014https://doi.org/10.1021/ja01068a014research-articleACS PublicationsRequest reuse permissionsArticle Views241Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Flowering Integrator, SOC1, Affects Stomatal Opening in Arabidopsis thaliana (2015)

Stomatal movements are regulated by multiple environmental signals. Recent investigations indicate that photoperiodic flowering components, such as CRY, GI, CO, FT and TSF, are expressed in guard cells and positively affect stomatal opening in Arabidopsis thaliana. Here we show that SOC1, which encodes a MADS box transcription factor and integrates multiple flowering signals, also exerts a positive effect on stomatal opening. FLC encodes a potent repressor of FT and SOC1, and FRI acts as an activator of FLC. Thus, we examined stomatal phenotypes in FRI-Col, which contains an active FRI allele of accession Sf-2 by introgression. We found higher expression of FLC and lower expression of FT, SOC1 and TSF in guard cells from FRI-Col than in those from Col. Light-induced stomatal opening was significantly suppressed in FRI-Col. Interestingly, vernalization of FRI-Col partially restored light-induced stomatal opening, concomitant with a decrease of FLC and increase of FT, SOC1 and TSF. Furthermore, we observed the constitutive open-stomata phenotype in transgenic plants overexpressing SOC1-GFP (green fluorescent protein) in guard cells (SOC1-GFP overexpressor), and found that light-induced stomatal opening was significantly suppressed in a soc1 knockout mutant. RNA sequencing using epidermis from the SOC1-GFP overexpressor revealed that the expression levels of several genes involved in stomatal opening, such as BLUS1 and the plasma membrane H(+)-ATPases, were higher than those in background plants. From these results, we conclude that SOC1 is involved in the regulation of stomatal opening via transcriptional regulation in guard cells.
Supercritical CO2 Extraction Applied to Oily Drilling Cuttings (2000)

Abstract With environmental concerns playing a growing role in the drilling industry, drilling waste disposal has become on unavoidable and important component of a drilling team’s scope of work. By end of year 2000, sea disposal of OPF (Organic Phase Fluid) will be phased out from the British North Sea area. Cutting Re-Injection or Ship-to-Shore for thermal, solvent or inerting treatments will be the only acceptable alternatives for oily cuttings disposal. The following paper presents an innovative approach to the complex problem of the separation of OBM from cuttings using Supercritical Carbon Dioxide technology (SCCO2). Above 73,8 bars and 35°C, Carbon Dioxide (CO2) exhibits special properties such as high density, high diffusivity and low viscosity, but above all, tremendous solvent properties regarding non-polar molecules such as hydrocarbons. This special state, sometimes referred to as the 4th state of matter, is widely known as the supercritical state. CO2 in supercritical conditions is already widely used in various industrial extraction processes, such as coffee bean decaffeination, fragrances and flavors selection or pharmaceutical molecules production. A pilot unit capable of handling up to 500g of cuttings per batch and allowing supercritical CO2 steady circulation, has been developed to study the efficiency of the process. Tests have been performed on oily cuttings coming from various locations and different OBM Cuttings. Best extraction conditions have been optimized and the efficiency of the separation has been very encouraging: Residual Oil Contents (ROC), as low as 0.2 % (by weight of dry cuttings) have been achieved. An evaluation on 2 larger scale units has also been made: a 6 kg static reactor and a 10 kg rotating autoclave (both dedicated to pre-industrial feasibility studies) enabled the evaluation of the efficiency of the treatment on North Sea OBM Cuttings. Residual oil contents below 1% have also been reached proving that scaling up the process, from hundreds of grams to several kilograms, is viable and practicable. The industrial potential of this promising technology is currently under study. The application of such a technology could constitute a major breakthrough in the drilling industry, both onshore and offshore.
X-ray photoelectron study of the reactive ion etching of Si<i>x</i>Ge1−<i>x</i> alloys in SF6 plasmas (1996)

Reactive ion etching of SixGe1−x alloys (0≤x≤100%) deposited on silicon wafers using the electron-beam evaporation technique was investigated in a low pressure fluorine-based plasma (SF6). The etch rates of the SixGe1−x alloys increase with the Ge content of the alloy but are constantly lower than the etch rates expected from independent etching mechanisms of Ge and Si atoms in the alloys. Analysis of the reactive layer on the surface of the alloys before and after etching was performed in situ by x-ray photoelectron spectroscopy (XPS). The reactive layer on the etched alloys consists of silicon, germanium, fluorine, and sulfur atoms. Fluorinated Ge (GeFn) and Si (SiFn) species, known to be precursors in the formation of the GeF4 and SiF4 etch products, are identified. A precise analysis of the sulfides of Ge (GeSn) and of Si (SiSn) present on the surface revealed a strong difference between sulfur–germanium and sulfur–silicon interactions by the detection of mostly GeS2 and SiS species. A sulfur-rich reactive layer is measured on the surface of the germanium-rich alloys, whereas a fluorine-rich layer exists on the surface of the silicon-rich alloys. Still, the sulfur-rich reactive layer exists over a large range of alloy stoichiometry (0≤x≤80%) with an increase of GeS2 density as a function of Si content in the alloy. The XPS analysis showed no enrichment of Ge or Si in the reactive layer compared to the substrate, suggesting equal etch rates of Ge and Si atoms of the alloy.
A novel Si/SiGe heterojunction pMOSFET with reduced short-channel effects and enhanced drive current (2000)

A novel Si/SiGe bandgap engineered pMOSFET structure, called a high mobility heterojunction transistor (HMHJT), is proposed. Reduced short-channel effects and high drive current are predicted in this new device. Simulation results of devices with 100-nm physical gate lengths are presented. Physical effects are illustrated, and the performance is compared to the conventional Si devices. For low standby power or low leakage (high V/sub T/) applications, the off-state leakage current due to drain induced barrier lowering (DIBL) or bulk punchthrough is substantially suppressed, and a very high I/sub on//I/sub off/ ratio of 6/spl times/10/sup 7/ is obtained in a HMHJT without any anti-punchthrough implant. This ratio is a factor of 180 higher than that of a fabricated, conventional Si device with a similar threshold voltage found in the literature. On the other hand, for lower operating power (low V/sub T/) applications, an HMHJT has a drive current 80% higher compared to an optimized Si device, while satisfying the same criteria for the off-state leakage current.
Synthesis and Crystal Structure of a New Salen Complex (2003)

Salen Schiff base complexes are some of the most important stereochemical models in transition metal coordina tion chemistry, with their ease of preparation and structural variation. [1] Salen complexes are extensively used as organic reaction catalysts, it was reported to be used in asymmetric cyclopropanation, epoxidation, aziridination, hydrolysis, alkylation, Diels-Alder reaction, reduction, oxidation etc. Here we report the synthesis and structure of a new salen nickel complex 4.……
A NEUROBIOLOGICAL ALTERNATIVE TO THE PERCEPTUAL REINFORCEMENT HYPOTHESIS OF STEREOTYPED BEHAVIOR: A COMMENTARY ON “SELF‐STIMULATORY BEHAVIOR AND PERCEPTUAL REINFORCEMENT” (1987)

A perceptual reinforcement theory of stereotyped movements is advanced by Lovaas, Newsom, and Hickman (1987) in an effort to integrate a number of diverse observations about the origins and maintenance of this behavior. We, in turn, argue that the theory, as presented, is logically flawed and fails to take into account important biological findings and theory concerning pathological stereotyped acts. An alternative theory, derived primarily from neurological concepts, is briefly described.
Dispersion properties of photonic crystal fibres (2002)

Approximate dispersion and bending properties of all-silica two-dimensional photonic crystal fibres are characterised by the combination of an effective-index model and classical analysis tools for opfical fibres.