gebhart/patrepeval huggingface dataset:
Impact of <i>sarA</i> on Antibiotic Susceptibility of <i>Staphylococcus aureus</i> in a Catheter-Associated In Vitro Model of Biofilm Formation (2009)

Mutation of the staphylococcal accessory regulator (sarA) in Staphylococcus aureus limits but does not abolish the capacity of the organism to form a biofilm. As a first step toward determining whether this limitation is therapeutically relevant, we carried out in vitro studies comparing the relative susceptibility of an S. aureus clinical isolate (UAMS-1) and its isogenic sarA mutant (UAMS-929) in the specific context of a catheter-associated biofilm. The antibiotics tested were daptomycin, linezolid, and vancomycin, all of which were evaluated by using concentrations based on the MIC defined as the breakpoint for a susceptible strain of S. aureus (< or = 1.0, < or = 2.0, and < or = 4.0 microg/ml for daptomycin, vancomycin, and linezolid, respectively). Mutation of sarA had no significant impact on the MIC of UAMS-1 for any of the targeted antibiotics, as defined by Etest antimicrobial susceptibility testing. However, mutation of sarA did result in a significant increase in antimicrobial susceptibility to all targeted antibiotics when they were tested in the specific context of a biofilm. Additionally, whether susceptibility was assessed by using UAMS-1 or its sarA mutant, daptomycin was found to be more effective against established S. aureus biofilms than either linezolid or vancomycin.
The relationship between interpersonal problems and negative childhood experiences (2008)

The purpose of this investigation was to examine the relationship between adult interpersonal functioning of women, currently in therapy wherein they were addressing unresolved issues about their childhood maltreatment, and childhood experiences referring to a developmental psychopathology framework. One hundred and twenty women (30 sexual abuse, 30 physical abuse, 30 family disruption, and 30 control) were individually presented with a series of audiotapes of three interpersonal situations (conflictual, neutral, dating), and asked to record their self-report of physiological response, self- and other-perceptions and coping responses. Physiological indices (heart rate, systolic and diastolic blood pressure) were also recorded, as well as self-report of childhood coping strategies. The data were examined as to whether abuse survivors in therapy addressing their childhood experiences have more interpersonal problems than non-clinical control subjects or than individuals having other types of traumatic backgrounds and whether any noted interpersonal difficulties are specific to the type of abuse, or general in nature. Results indicated that abusive experiences are related to greater dysfunction in regards to self- and other-perceptions than exposure to disruptive/chaotic family environments alone. However, the differences appear to be variable-specific and few differences were obtained on physiological and coping variables. Some specific problems in adult interpersonal functioning were evidenced between the sexual and physical abuse groups. Specifically, in comparison to the physical abuse survivors, sexual abuse survivors reported greater use of different, and perhaps less adaptive, coping strategies in neutral situations. No other dependent variables significantly differed between the two groups. The results were discussed in terms of theoretical and empirical issues related to abuse-specific outcomes, the specific methodology employed in this study, and directions for future research.
Action Spectrum for an Enhancement of Endogenous Respiration by Light in <i>Chlorella</i> (1967)

The oxygen consumption of a starved chlorophyll-free, yellow mutant of Chlorella vulgaris is enhanced by very small amounts of blue light (lambda 450 mmu); a saturation level is reached at about 500 ergs cm(-2) sec(-1). At that intensity the respiration is about 3 times greater than in the dark. An action spectrum for the enhancement of respiration shows 2 peaks around lambda 450 and 375 mmu. Flavins and cis-carotenoids are discussed as the pigments involved.
The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing (2003)

Recent studies of a relatively rare hereditary cancer syndrome, von Hippel-Lindau (VHL) disease, have shed new light on the molecular pathogenesis of kidney cancer and, perhaps more important, on how mammalian cells sense and respond to changes in oxygen availability. This knowledge is already translating into new therapeutic targets for kidney cancer as well as for multiple conditions, such as myocardial infarction and stroke, in which ischemia plays a pathogenic role. This review summarizes the current knowledge of the molecular pathogenesis of von Hippel-Lindau disease and the role of the VHL gene product (pVHL) in kidney cancer and the mammalian oxygen sensing pathway.
Message from the Vice President: Let's have mofe applicattons papers for G-AP TRANSACTIONS (1973)

One of the most common comments from the membership is that G-AP should publish more applications papers in the Transactions. This also is one of our most widely agreed upon issues. It is difficult to find anyone who opposes the idea. The question is, how do we go about doing it? The fact is, these papers are not being submitted in sufficient quantity to our Transactions (Editor, Rick Ricardi). These papers must come from you, the members who want them. Submit papers on the interesting, practical A and P work that you are doing. The reviewers will not turn down a good practical paper. Besides, those of you who submit these papers may get your names on Rick's list of potential reviewers and soon find yourselves reviewing the applications papers.
Experimental study of damping flexural vibrations in tapered turbofan blades (2012)

In this paper, the results of the experimental investigations into damping of flexural vibrations in turbofan blades with trailing edges tapered according to a power-law profile are reported. Edges of power-law profile (wedges), with small pieces of attached absorbing layers, materialise one-dimensional acoustic black holes for flexural waves that can absorb a large proportion of the incident flexural wave energy. The NACA 1307 aerofoil was used as a base model for experimental samples. This model was modified to form four samples of non-enginespecific model fan blades. Two of them were then twisted, so that a more realistic fan blade could be considered. All model blades, the ones with tapered trailing edges and the ones of traditional form, were excited by an electromagnetic shaker, and the corresponding frequency response functions have been measured. The results show that the fan blades with power-law tapered edges have the same pattern of damping that can be seen for plates with attached wedges of power-law profile, when compared to their respective reference samples. The resonant peaks are reduced substantially once a power-law tapering is introduced to the sample. The obtained results demonstrate that power-law tapering of trailing edges of turbofan blades can be a viable method of reduction of blade vibrations.
Einleitung (1990)

Der gleiche Autor, Theodor W. Adorno, schreibt in einem Brief am 10.1. 1938 an Walter Benjamin: „Ich (...) versuche im übrigen für meine Abneigung gegen jene besondere Art des Konkreten und dessen behaviouristische Züge Ihnen den theoretischen Grund anzugeben. Der ist aber kein anderer, als daö ich es für methodisch unglücklich halte, einzelne sinnfällige Züge aus dem Bereich des überbaus ‚materialistisch‘ zu wenden, indem man sie zu entsprechenden Zügen des Unterbaus unvermittelt und wohl gar kausal in Beziehung setzt. Die materialistische Determination kultureller Charaktere ist möglich nur vermittelt durch den Gesamtprozeß. (...) die Wiederkehr jener Motive (...) ist nicht anders zu bestimmen als durch die gesellschaftliche und ökonomische Gesamttendenz des Zeitalters (...).“
Ontogeny and localization of TGF-β type I receptor expression during lung development (2000)

Transforming growth factor (TGF)-beta is a family of multifunctional cytokines controlling cell growth, differentiation, and extracellular matrix deposition in the lung. The biological effects of TGF-beta are mediated by type I (TbetaR-I) and II (TbetaR-II) receptors. Our previous studies show that the expression of TbetaR-II is highly regulated in a spatial and temporal fashion during lung development. In the present studies, we investigated the temporal-spatial pattern and cellular expression of TbetaR-I during lung development. The expression level of TbetaR-I mRNA in rat lung at different embryonic and postnatal stages was analyzed by Northern blotting. TbetaR-I mRNA was expressed in fetal rat lungs in early development and then decreased as development proceeded. The localization of TbetaR-I in fetal and postnatal rat lung tissues was investigated by using in situ hybridization performed with an antisense RNA probe. TbetaR-I mRNA was present in the mesenchyme and epithelium of gestational day 14 rat lungs. An intense TbetaR-I signal was observed in the epithelial lining of the developing bronchi. In gestational day 16 lungs, the expression of TbetaR-I mRNA was increased in the mesenchymal tissue. The epithelium in both the distal and proximal bronchioles showed a similar level of TbetaR-I expression. In postnatal lungs, TbetaR-I mRNA was detected in parenchymal tissues and blood vessels. We further studied the expression of TbetaR-I in cultured rat lung cells. TbetaR-I was expressed by cultured rat lung fibroblasts, microvascular endothelial cells, and alveolar epithelial cells. These studies demonstrate a differential regulation and localization of TbetaR-I that is different from that of TbetaR-II during lung development. TbetaR-I, TbetaR-II, and TGF-beta isoforms exhibit distinct but overlapping patterns of expression during lung development. This implies a distinct role for TbetaR-I in mediating TGF-beta signal transduction during lung development.
Influence of Lower Body Positive Pressure on Upper Airway Cross-Sectional Area in Drug-Resistant Hypertension (2012)

We previously showed that in hypertensive patients the amount of fluid displaced from the legs overnight is directly related to the severity of obstructive sleep apnea and that the rostral fluid shift was greater in drug-resistant hypertensive patients. The findings suggested that this fluid redistribution increases upper airway collapsibility, yet more direct evidence is lacking. The present study examines the effects of graded lower body positive pressure on leg fluid volume, upper airway cross-sectional area, and neck circumference in patients with drug-resistant hypertension (n=25) and controlled hypertension (n=15). In both groups, the reduction in mean upper airway cross-sectional area and oropharyngeal junction area, assessed by acoustic pharyngometry, and the increase in neck circumference, determined by mercury strain gauge plethysmography, were related to the amount of fluid displaced from the legs (R(2)=0.41, P<0.0001; R(2)=0.42, P<0.0001; and R(2)=0.47, P<0.0001, respectively). Displacement of leg fluid volume was significantly greater in patients with drug-resistant hypertension than in controlled hypertension (P<0.0001), and as a consequence, the former experienced greater reductions in mean upper airway cross-sectional area and oropharyngeal junction area (P=0.001 and P<0.0001, respectively). The findings support the concept that in hypertensive subjects, rostral fluid displacement may participate in the pathogenesis of obstructive sleep apnea by narrowing the upper airway and making it more susceptible to collapse during sleep. The exaggerated fluid volume displacement from the legs and upper airway response to lower body positive pressure in patients with drug-resistant hypertension provide additional evidence of an important link between drug-resistant hypertension and obstructive sleep apnea.
Advances in structural damage diagnostic research: Architectural design, modeling and validation (2009)

Physical damages like thermally grown oxide (TGO) layer develop in the coated gas turbine blade during the aeroengine operation and severely limits the life and performance. This life critical damage data has been considered for the validation of a diagnostic fault analysis. High level architecture, statistical algorithm and experimental modeling of oxide growth data are discussed. Experimental measurement of the damage growth has been carried out under different time, temperature and processing conditions in coated blade to generate large volume of input data. Wilcoxon rank sum analysis is carried out to check its effectiveness. The proposed method appears to yield consistent result in operational data anomaly and damage diagnosis. The algorithm for prognostic analysis using exponential smoothing of damage data from gas turbine engine and nonlinear regression method will be applied for future work.
Crocetin Esters, Picrocrocin and Its Related Compounds Present in <i>Crocus sativus</i> Stigmas and <i>Gardenia jasminoides</i> Fruits. Tentative Identification of Seven New Compounds by LC-ESI-MS (2006)

Crocetin esters present in saffron (Crocus sativus L.) stigmas and in Gardenia jasminoides Ellis fruit are the compounds responsible for their color. Of the fifteen crocetin esters identified in this study, five new compounds were tentatively identified: trans and cis isomers of crocetin (beta-D-triglucoside)-(beta-D-gentibiosyl) ester, trans and cis isomers of crocetin (beta-D-neapolitanose)-(beta-D-glucosyl) ester, and cis crocetin (beta-D-neapolitanose)-(beta-D-gentibiosyl) ester. The most relevant differences between both species were a low content of the trans crocetin (beta-D-glucosyl)-(beta-D-gentibiosyl) ester, the absence of trans crocetin di-(beta-D-glucosyl) ester in gardenia, and its higher content of trans crocetin (beta-D-gentibiosyl) ester and cis crocetin di-(beta-D-gentibiosyl) ester. With the same chromatographic method it was possible to identify, in a single run, ten glycosidic compounds in saffron extracts with a UV/vis pattern similar to that of picrocrocin; among them, 5-hydroxy-7,7-dimethyl-4,5,6,7-tetrahydro-3H-isobenzofuranone 5-O-beta-D-gentibioside and 4-hydroxymethyl-3,5,5-trimethyl-cyclohexen-2-one 4-O-beta-D-gentibioside were tentatively identified for the first time in saffron. Of these ten glycosides, only the O-beta-D-gentibiosyl ester of 2-methyl-6-oxo-2,4-hepta-2,4-dienoic acid was found in gardenia samples, but it was possible to identify the iridoid glycoside, geniposide.
Highly Sensitive Electric Discharge Detector for Chromatographic Analysis. (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Sensitive Electric Discharge Detector for Chromatographic Analysis.E. R. Fisher and Maclyn. McCartyCite this: Anal. Chem. 1965, 37, 10, 1208–1210Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/ac60229a008https://doi.org/10.1021/ac60229a008research-articleACS PublicationsRequest reuse permissionsArticle Views30Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel signaling scheme for 1x CDMA-based femtocell networks (2010)

Femtocell networks can support iosolated coverage area and provide high data rates for mobile users by using wired Internet lines such as xDSL and cable TV networks for backhaul connectivity. Femtocell networks can be classified into 3GPP UMTS-based networks and 1x CDMA-based networks. Although 3GPP UMTS-based femtocells are standardized in the form of Home Node-B, 1x CDMA-based femtocells are not currently standardized. So, operators and communication system vendors are developing and launching such networks with proprietary specifications. From the viewpoint of an operator seeking to reduce its setup-costs, the adoption of the Femto Access GateWay (FAGW) is preferred. If femtocell networks based on the FAGW are adopted, an efficient signaling between the femtocells and the FAGW is required. The SIP-based signaling technique may suffer from an overload to support large number of femtocells. In this paper, we propose a novel signaling mechanism for FAGW and evaluate its performance in comparison with the SIP-based signaling method.
Idea de salud para culturas originarias mesoamericanas e idea de salud para los orientales (bosquejo comparativo) (2004)

Resumen En la cultura occidental diferenciamos salud de idea de salud, considerandolas objeto de estudio de diferentes ciencias. En las culturas tradicionales orientales, salud e idea de salud forman una unidad en la que lo cultural y lo natural se entienden de manera integrada, no viendose la necesidad de delimitar campos como se hace en la cultura occidental. Salud es un equilibrio de energias (de la persona y de los distintos ambientes). Para las culturas tradicionales mesoamericanas (centrandonos en Oaxaca), salud es equilibrio, como resultado del continuo ajuste de elementos pertenecientes al ser humano, al medio social, al medio natural, al medio cultural y al medio espiritual, interrelacionados. En ambas concepciones equilibrio es tension de fuerzas, una de ellas correspondiente a la actuacion humana (correccion, ajuste, reajuste,..). Basandonos en la opinion generalizada de los expertos, que atribuyen un origen asiatico a los pueblos americanos, podriamos extender tambien el parentesco a lo cultural (como sugieren algunos autores), es decir a las ideas, y en concreto a la concepcion de salud/enfermedad.
Living carbocationic copolymerizations. I. Synthesis and characterization of isobutylene/<i>p</i>‐methylstyrene copolymers (1995)

Abstract The isobutylene (IB)– p ‐methylstyrene (pMeSt) monomer pair readily produces by living copolymerization nearly random copolymers with up to M̄ n ≈ 50,000 g mol −1 and M̄ w /M̄ n ≈ 1·4. The livingness of the copolymerization process and the compositional homogeneity of the copolymers have been demonstrated by the following four diagnostic plots: (A) M̄ n (number‐average molecular weight) and corresponding N (number of moles of copolymer formed) vs W p (weight of copolymer formed) for the diagnosis of chaintransfer; (B) −ln (1 – C ) ( C = conversion of monomers) vs time for the diagnosis of termination; (C) copolymer composition vs molecular weight; and (D) cumulative copolymer composition vs conversion for the diagnosis of true homogeneous copolymers. The theory for the use of the −ln(1 – C ) vs time plot for the quantitation of irreversible termination in copolymerization has been developed. The exact conditions (i.e. nature of reagents, reagent concentrations, temperature, etc.) which lead to desirable products in terms of conversion, molecular weight, molecular weight distribution (MWD) and copolymer composition, were developed systematically by analyzing the results of a large number of experiments. The following combination of chemicals was found to lead to living copolymerization, and uniform high molecular weight, narrow MWD copolymers: IB–pMeSt 97 : 3 mol/mol with 5‐ tert ‐butyl‐1,3‐dicumyl methyl ether (5‐tBu‐1,3‐DiCumOMe) initiator, TiCl 4 coinitiator, ethyl chloride (EtCl) solvent, triethylamine (TEA) electron pair donor (ED) and 2,6‐di‐ tert ‐butylpyridine (DtBP) proton trap at −52, −65 and −85°C.
Prediction and Fault Detection of Environmental Signals with Uncharacterised Faults (2021)

Many signals of interest are corrupted by faults of anunknown type. We propose an approach that uses Gaus-sian processes and a general “fault bucket” to capturea priori uncharacterised faults, along with an approxi-mate method for marginalising the potential faultinessof all observations. This gives rise to an efficient, flexible algorithm for the detection and automatic correction of faults. Our method is deployed in the domain of water monitoring and management, where it is able to solve several fault detection, correction, and prediction problems. The method works well despite the fact that the data is plagued with numerous difficulties, including missing observations, multiple discontinuities, nonlinearity and many unanticipated types of fault.
Investigational A<sub>3</sub>adenosine receptor targeting agents (2011)

Given the existence of both preclinical and early clinical data supporting the utility of A(3) adenosine receptor ligands in treating immune-related diseases, further development of A(3) adenosine receptor ligands is anticipated.
The Debate Over Digital Online Content: Understanding the Issues (2002)

This paper presents an overview of the legal and policy issues associated with online content, such as music, including specifically copyright issues associated with peer-to-peer distribution software such as Grokster. We conclude that robust copyright laws (and the enforcement of same) are essential to the development of a healthy marketplace for online content.
Identification of fungicidal and nematocidal components in the leaves of Piper betle (Piperaceae) (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIdentification of fungicidal and nematocidal components in the leaves of Piper betle (Piperaceae)Philip H. Evans, William S. Bowers, and Evangeline J. FunkCite this: J. Agric. Food Chem. 1984, 32, 6, 1254–1256Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/jf00126a011https://doi.org/10.1021/jf00126a011research-articleACS PublicationsRequest reuse permissionsArticle Views551Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts