gebhart/patrepeval huggingface dataset:
Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 <b> <i>in Vitro</i> </b> (2004)

Imatinib mesylate (Gleevec, STI571) is a kinase inhibitor selective for Bcr-Abl, activated c-Kit kinases, and platelet-derived growth factor receptor tyrosine kinase. Imatinib mesylate, similar to many other tyrosine kinase inhibitors (TKIs), such as members of the 4-anilinoquinazoline class, competes for ATP binding. Previously, 4-anilinoquinazoline TKIs have been shown to inhibit the function of the breast cancer resistance-associated drug transporter (ABCG2), reversing resistance to camptothecin derivatives topotecan and SN-38. However, the potential to inhibit ABCG2 for the 2-phenylamino-pyrimidine class of TKIs, exemplified by imatinib mesylate, has not been examined. Here, we show that imatinib mesylate potently reverses ABCG2-mediated resistance to topotecan and SN-38 and significantly increases accumulation of topotecan only in cells expressing functional ABCG2. However, overexpression of ABCG2 does not confer resistance to imatinib mesylate. Furthermore, accumulation and efflux of [(14)C]imatinib mesylate are unaltered between ABCG2-expressing and non-ABCG2-expressing cells or by ATP depletion. These results suggest that imatinib mesylate inhibits the function of ABCG2 but is not a substrate for this transporter.
Real-Time Eye Detection and Tracking under Various Light Conditions (2007)

The CODATA Data Science Journal is a peer-reviewed, open access, electronic journal, publishing papers on the management, dissemination, use and reuse of research data and databases across all research domains, including science, technology, the humanities and the arts. The scope of the journal includes descriptions of data systems, their implementations and their publication, applications, infrastructures, software, legal, reproducibility and transparency issues, the availability and usability of complex datasets, and with a particular focus on the principles, policies and practices for open data.All data is in scope, whether born digital or converted from other sources.
Manufacturing a 9-Meter Thermoplastic Composite Wind Turbine Blade (2017)

Currently, wind turbine blades are manufactured from a combination of glass and/or carbon fiber composite materials with a thermoset resin such as epoxy, which requires energy-intensive and expensive heating processes to cure. Newly developed in-situ polymerizing thermoplastic resin systems for composite wind turbine blades polymerize at room temperature, eliminating the heating process and significantly reducing the blade manufacturing cycle time and embodied energy, which in turn reduces costs. Thermoplastic materials can also be thermally welded, eliminating the need for adhesive bonds between blade components and increasing the overall strength and reliability of the blades. As well, thermoplastic materials enable end-oflife blade recycling by reheating and decomposing the materials, which is a limitation of existing blade technology. This paper presents a manufacturing demonstration for a 9-m-long thermoplastic composite wind turbine blade. This blade was constructed in the Composites Manufacturing Education and Technology facility at the National Wind Technology Center at the National Renewable Energy Laboratory (NREL) using a vacuumassisted resin transfer molding process. Johns Manville fiberglass and an Arkema thermoplastic resin called Elium were used. Additional materials included Armacellrecycled polyethylene terephthalate foam from Creative Foam and low-cost carbonfiber pultruded spar caps (manufactured in collaboration with NREL, Oak Ridge National Laboratory, Huntsman, Strongwell, and Chomarat). This paper highlights the development of the thermoplastic resin formulations, including an additive designed to control the peak exothermic temperatures. Infusion and cure times of less than 3 hours are also demonstrated, highlighting the efficiency and energy savings associated with manufacturing thermoplastic composite blades.
Adenosine and Migraine (1998)

We have reached a dual conclusion: 1) during migraine headaches there is an increase (mean 68%) in circulating adenosine levels and this increase may participate in cephalalgia; 2) activation of A2 receptors by adenosine causes a dose-dependent serotonin uptake by platelets. This inhibition of uptake could participate in the rapid elimination of serotonin in migraine sufferers. As a result of this, the use of adenosine antagonists could be an effective complementary treatment for migraine.
CONTINGENT CLAIMS VALUED AND HEDGED BY PRICING AND INVESTING IN A BASIS (1994)

Contingent claims with payoffs depending on finitely many asset prices are modeled as elements of a separable Hilbert space. Under fairly general conditions, including market completeness, it is shown that one may change measure to a reference measure under which asset prices are Gaussian and for which the family of Hermite polynomials serves as an orthonormal basis. Basis pricing synthesizes claim valuation and basis investment provides static hedging opportunities. For claims written as functions of a single asset price we infer from observed option prices the implicit prices of basis elements and use these to construct the implied equivalent martingale measure density with respect to the reference measure, which in this case is the Black‐Scholes geometric Brownian motion model. Data on S & P 500 options from the Wall Street Journal are used to illustrate the calculations involved. On this illustrative data set the equivalent martingale measure deviates from the Black‐Scholes model by relatively discounting the larger price movements with a compensating premia placed on the smaller movements.
Combination Therapy with Inhaled Long‐Acting β<sub>2</sub>‐Agonists and Inhaled Corticosteroids: A Paradigm Shift in Asthma Management (2002)

Long-acting inhaled beta2-agonists and inhaled corticosteroids are classes of drugs with different mechanisms of action that are commonly used to provide effective long-term control of persistent asthma. Scientific and clinical data support the complementary mechanisms of action of the inhaled corticosteroids and the long-acting beta2-agonists in achieving a superior level of asthma control. In addition, evidence supports significant reductions in exacerbations and effective control of airway inflammation with an inhaled corticosteroid and a long-acting beta2-agonist versus higher dosages of inhaled corticosteroids or combinations of other therapeutic agents with an inhaled corticosteroid. Finally, there are distinct economic advantages to combining an inhaled corticosteroid and a long-acting beta2-agonist in the treatment of asthma relative to other treatment regimens.
A stable carbene-alane adduct (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA stable carbene-alane adductAnthony J. Arduengo III, H. V. Rasika Dias, Joseph C. Calabrese, and Fredric DavidsonCite this: J. Am. Chem. Soc. 1992, 114, 24, 9724–9725Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00050a098https://doi.org/10.1021/ja00050a098research-articleACS PublicationsRequest reuse permissionsArticle Views1584Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Insertion of Ia and H-2 alloantigens into model membranes. (1979)

The study of immune phenomena dependent on the major histocompatibility complex (MHC) would be greatly simplified by the use of MHC antigen-containing liposomes in various functional systems. Towards this end, we have constructed unilamellar phosphatidylcholine liposomes containing H-2 and Ia antigens. These molecules were not simply trapped within the aqueous compartment of the liposome as assessed by their accessibility to papain digestion. They were shown to be integrally inserted in the liposome bilayer because they could not be dissociated from the liposome with high salt and EDTA concentrations but could be solubilized by detergent. A sensitive radioimmunoassay showed that the Ia molecules were antigenically active in the liposome environment. Both Ia and H-2 antigens could be immunoprecipitated from detergent-solubilized liposomes. By comparing liposome-associated Ia activity in the presence and absence of detergent and by showing accessibility of the Ia antigens to papain, it was concluded that the majority of Ia antigens were exposed on the external surface of the liposome. These results suggest that the orientation of MHC antigens in liposomes closely parallels their natural orientation in the cell membrane.
A differentially methylated region of the DAZ1 gene in spermatic and somatic cells (2006)

A differentially methylated region of the DAZ1 gene exists in spermatic and somatic cells, suggesting that methylation of this region may regulate DAZ1 gene expression in different tissues.
Primitives for computational geometry (1988)

Many geometric algorithms become simpler, more general, and more efficient when recast in the language of projective geometry. Some reasons for this are the uniform handling of points at infinity, the attendant reduction in the number of special cases, and the perfect duality between points and hyperplanes that are possible in the projective model. In fact, the homogeneous coordinates so widely used in computer graphics are essentially an analytical model of classical projective geometry.
However, projective space is topologically quite different from Euclidean space. For example, in the projective plane lines have only one side, all triangles have the same handedness, and there are two distinct segments with any given pair of endpoints. These differences are a serious practical problem, since many geometric algorithms depend on orientation, ordering and separation tests that make sense only in the Euclidean model.
This dissertation describes a slightly modified form of projective geometry which is free from this problem. Analytically, the change consists in making the signs of homogeneous coordinates more significant. Geometrically, the change consists in adopting oriented lines and planes as the elementary objects of the model, and redefining the basic geometric operation of meet and join so as to produce results with a definite orientation. Topologically, this is equivalent to working with a double covering projective space, which is equivalent to an n-dimensional sphere.
The resulting framework, here called oriented projective geometry, combines the elegance of classical projective geometry with the ability to talk about oriented lines and planes, signed angles, line segments, convex figures, and many other concepts that cannot be conveniently defined within that model. The goals of this dissertation are: (1) to develop an intuitive understanding of oriented projective geometry in two and three dimensions; (2) to describe a formal geometric calculus for handling oriented lines, planes, and flat spaces of arbitrary dimension; and (3) to investigate the efficient representation of such objects in computers.
Sulfono‐γ‐AApeptides as a New Class of Nonnatural Helical Foldamer (2014)

Foldamers offer an attractive opportunity for the design of novel molecules that mimic the structures and functions of proteins and enzymes including biocatalysis and biomolecular recognition. Herein we report a new class of nonnatural helical sulfono-γ-AApeptide foldamers of varying lengths. The crystal structure of the sulfono-γ-AApeptide monomer S6 illustrates the intrinsic folding propensity of sulfono-γ-AApeptides, which likely originates from the bulkiness of tertiary sulfonamide moiety. The two-dimensional solution NMR spectroscopy data for the longest sequence S1 demonstrates a 10/16 right-handed helical structure. Optical analysis using circular dichroism further supports well- defined helical conformation of sulfono-γ-AApeptides in solution containing as few as five building blocks. Future development of sulfono-γ-AApeptides may lead to new foldamers with discrete functions, enabling expanded application in chemical biology and biomedical sciences.
Code Coverage of Adaptive Random Testing (2013)

Random testing is a basic software testing technique that can be used to assess the software reliability as well as to detect software failures. Adaptive random testing has been proposed to enhance the failure-detection capability of random testing. Previous studies have shown that adaptive random testing can use fewer test cases than random testing to detect the first software failure. In this paper, we evaluate and compare the performance of adaptive random testing and random testing from another perspective, that of code coverage. As shown in various investigations, a higher code coverage not only brings a higher failure-detection capability, but also improves the effectiveness of software reliability estimation. We conduct a series of experiments based on two categories of code coverage criteria: structure-based coverage, and fault-based coverage. Adaptive random testing can achieve higher code coverage than random testing with the same number of test cases. Our experimental results imply that, in addition to having a better failure-detection capability than random testing, adaptive random testing also delivers a higher effectiveness in assessing software reliability, and a higher confidence in the reliability of the software under test even when no failure is detected.
Plasmid-Located Pathogenicity Determinants of <i>Serratia entomophila</i> , the Causal Agent of Amber Disease of Grass Grub, Show Similarity to the Insecticidal Toxins of <i>Photorhabdus luminescens</i> (2000)

Serratia entomophila and Serratia proteamaculans cause amber disease in the grass grub Costelytra zealandica (Coleoptera: Scarabaeidae), an important pasture pest in New Zealand. Larval disease symptoms include cessation of feeding, clearance of the gut, amber coloration, and eventual death. A 115-kb plasmid, pADAP, identified in S. entomophila is required for disease causation and, when introduced into Escherichia coli, enables that organism to cause amber disease. A 23-kb fragment of pADAP that conferred disease-causing ability on E. coli and a pADAP-cured strain of S. entomophila was isolated. Using insertion mutagenesis, the pathogenicity determinants were mapped to a 17-kb region of the clone. Sequence analysis of the 17-kb region showed that the predicted products of three of the open reading frames (sepA, sepB, and sepC) showed significant sequence similarity to components of the insecticidal toxin produced by the bacterium Photorhabdus luminescens. Transposon insertions in sepA, sepB, or sepC completely abolished both gut clearance and cessation of feeding on the 23-kb clone; when recombined back into pADAP, they abolished gut clearance but not cessation of feeding. These results suggest that SepA, SepB, and SepC together are sufficient for amber disease causation by S. entomophila and that another locus also able to exert a cessation-of-feeding effect is encoded elsewhere on pADAP.
Inactivation of <i>RASSF2A</i> by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma (2006)

RASSF2 can bind directly to K-Ras and function as a negative effector of Ras protein. RASSF2A is the only isoform of RASSF2 that contains CpG islands in its promoter and it has been reported to be inactivated by its promoter methylation in several human cancers. In the present study, we investigated the correlation of RASSF2A expression with its promoter methylation in nasopharyngeal carcinoma (NPC). Expression of RASSF2A was down-regulated in 80% (4/5) of NPC cell lines. Decreased RASSF2A expression was also observed in NPC primary tumors compared with normal nasopharyngeal epithelia. Promoter methylation of RASSF2A could be detected in all the RASSF2A-silenced cell lines (4/5) of the NPC cell lines and 50.9% (27/53) of primary tumors, but not in any of the normal epithelia. RASSF2A-methylated cases showed a significantly lower level of RASSF2A expression than unmethylated cases. Loss of RASSF2A expression can be greatly restored by the methyltransferase inhibitor 5-aza-dC in NPC cell lines. In addition, patients with methylated RASSF2A presented a higher frequency of lymph node metastasis (p < 0.05). Ectopic expression of RASSF2A in RASSF2A-silenced and -methylated NPC cell line CNE2 shows that RASSF2A could inhibit cell cycle progression, colony formation and cell migration, which provided further evidence that RASSF2A is a candidate tumor suppressor gene. In conclusion, RASSF2A, a candidate tumor suppressor gene (TSG), is frequently inactivated by its promoter methylation and this aberrant methylation correlates with lymph node metastasis in NPC.
The effect of an endogenous compound 1-methyl-1,2,3,4,-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures. (2007)

1,2,3,4-Tetrahydroisoquinolines, among them the most interesting neuroprotective substance, an inhibitor of MAO, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), are endogenous compounds present in the central nervous system of mammals and humans. In this study, we investigated the effect of 1MeTIQ on morphine-induced analgesia, tolerance and abstinence syndrome as well as its effect on morphine-induced changes in dopamine metabolism in rat brain structures (nucleus accumbens, striatum, substantia nigra) using HPLC methodology. The experiments were carried out on male Wistar rats. Morphine analgesia was measured in the "hot-plate" test. To induce tolerance, morphine was given chronically (20 mg/kg i.p.) alone or following 1MeTIQ (50 mg/kg i.p.) injection. The development of dependence was assessed in the naloxone (2 mg/kg i.p.) precipitation test, after 10 days of morphine administration. The behavioral studies have shown that an endogenous compound, 1MeTIQ produced strong potentiation of morphine analgesia, prevented the development of morphine tolerance and inhibited expression of morphine abstinence syndrome in morphine-dependent rats. In neurochemical studies, we have demonstrated that 1MeTIQ antagonized morphine-induced changes in dopamine metabolism observed in rat brain structures. The main finding of this study was demonstration for the first time of an anti-abuse effect of an endogenous compound, 1MeTIQ, and its efficiency in counteracting morphine-induced addiction in the way useful from clinical point of view. The obtained results suggested a possibility of clinical application of 1MeTIQ in morphine addiction.
Broadband lidar technique for precision CO (2008)

Presented are preliminary experimental results, sensitivity measurements and discuss our new CO2 lidar system under development. The system is employing an erbium-doped fiber amplifier (EDFA), superluminescent light emitting diode (SLED) as a source and our previously developed Fabry-Perot interferometer subsystem as a detector part. Global measurement of carbon dioxide column with the aim of discovering and quantifying unknown sources and sinks has been a high priority for the last decade. The goal of Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission is to significantly enhance the understanding of the role of CO2 in the global carbon cycle. The National Academy of Sciences recommended in its decadal survey that NASA put in orbit a CO2 lidar to satisfy this long standing need. Existing passive sensors suffer from two shortcomings. Their measurement precision can be compromised by the path length uncertainties arising from scattering within the atmosphere. Also passive sensors using sunlight cannot observe the column at night. Both of these difficulties can be ameliorated by lidar techniques. Lidar systems present their own set of problems however. Temperature changes in the atmosphere alter the cross section for individual CO2 absorption features while the different atmospheric pressures encountered passing through the atmosphere broaden the absorption lines. Currently proposed lidars require multiple lasers operating at multiple wavelengths simultaneously in order to untangle these effects. The current goal is to develop an ultra precise, inexpensive new lidar system for precise column measurements of CO2 changes in the lower atmosphere that uses a Fabry-Perot interferometer based system as the detector portion of the instrument and replaces the narrow band laser commonly used in lidars with the newly available high power SLED as the source. This approach reduces the number of individual lasers used in the system from three or more to one - considerably reducing the risk of failure. It also tremendously reduces the requirement for wavelength stability in the source putting this responsibility instead on the Fabry-Perot subsystem.
A Distributed Spatial-Temporal Similarity Data Storage Scheme in Wireless Sensor Networks (2010)

Since centralized data storage and search schemes often lead to high overhead and latency, distributed data-centric storage becomes a preferable approach in large-scale wireless sensor networks (WSNs). However, most of existing distributed methods lack optimization for spatial-temporal search to query events occurred in a certain geographical area and a certain time period. Furthermore, for data search routing, most methods rely on locating systems (e.g., GPS), which consume high energy. This paper proposes a distributed spatial-temporal Similarity Data Storage (SDS) scheme. SDS provides efficient spatial-temporal and similarity data searching service, and is applicable for both static and dynamic WSNs. It disseminates event data in such a way that the distance between WSN neighborhoods represents the similarity of data stored in them. In addition, SDS carpooling routing algorithm efficiently routes messages without the aid of GPS. Theoretical and experimental results show that SDS yields significant improvements on the efficiency of data querying compared with existing approaches, and obtains stable performance in dynamic environments.