gebhart/patrepeval huggingface dataset:
Immunologic Evaluation of Ofloxacin Hypersensitivity (2012)

Quinolone hypersensitivity, most of which is immediate type, is rare but has increased in recent years. The pathogenic mechanisms underlying immediate reactions are not defined clearly. This study was aimed to observe the clinical characteristics of immediate hypersensitivity to ofloxacin and to investigate the pathogenic mechanism with detection of serum specific IgE to ofloxacin using an enzyme-linked immunoasorbent assay (ELISA). We recruited 5 patients with immediate hypersensitivity reactions to ofloxacin (group I), and as control groups, 5 subjects with ciprofloxacin hypersensitivity (group II) and 20 healthy subjects with no history of drug allergy. Serum specific-IgE to ofloxacin-human serum albumin (HSA) conjugate was detectable in four group I subjects (80%) and three group II subjects (60%). The ELISA inhibition test showed significant inhibition with both ofloxacin-HSA conjugate and free ofloxacin in a dose-dependent manner. As to ciprofloxacin, significant inhibition was noted upon addition of free ciprofloxacin in one subject, while minimal inhibition was noted in the other. We confirmed that an IgE-mediated response is a major pathogenic mechanism of ofloxacin hypersensitivity. Cross reactivity between ofloxacin and ciprofloxacin was noted with individual difference.
Ultrasound Strain Imaging of Altered Myocardial Stiffness (2004)

Early after postischemic reperfusion and in the presence of severely reduced systolic deformation, diastolic passive deformation (and rates of deformation) can distinguish stiff, noncompliant, transmurally infarcted myocardial walls from those more compliant walls containing viable but stunned myocardium.
Segmentation of polycystic kidneys from MR images (2010)

Polycystic kidney disease (PKD) is a disorder characterized by the growth of numerous fluid filled cysts in the kidneys. Measuring cystic kidney volume is thus crucial to monitoring the evolution of the disease. While T2-weighted MRI delineates the organ, automatic segmentation is very difficult due to highly variable shape and image contrast. The interactive stereology methods used currently involve a compromise between segmentation accuracy and time. We have investigated semi-automated methods: active contours and a sub-voxel morphology based algorithm. Coronal T2- weighted images of 17 patients were acquired in four breath-holds using the HASTE sequence on a 1.5 Tesla MRI unit. The segmentation results were compared to ground truth kidney masks obtained as a consensus of experts. Automatic active contour algorithm yielded an average 22% ± 8.6% volume error. A recently developed method (Bridge Burner) based on thresholding and constrained morphology failed to separate PKD from the spleen, yielding 37.4% ± 8.7% volume error. Manual post-editing reduced the volume error to 3.2% ± 0.8% for active contours and 3.2% ± 0.6% for Bridge Burner. The total time (automated algorithm plus editing) was 15 min ± 5 min for active contours and 19 min ± 11 min for Bridge Burner. The average volume errors for stereology method were 5.9%, 6.2%, 5.4% for mesh size 6.6, 11, 16.5 mm. The average processing times were 17, 7, 4 min. These results show that nearly two-fold improvement in PKD segmentation accuracy over stereology technique can be achieved with a combination of active contours and postediting.
Above-band-gap photoluminescence from Si fine particles with oxide shell (1991)

Strong photoluminescence with sub-band-gap photon energies has been observed in fine Si particles prepared by the gas-evaporation technique. After surface oxidation, the Si particles show above-band-gap photoluminescence, the band tail covering the visible light region. The amount of the increased apparent band gap (0.3 eV) estimated from this blueshift can be explained by a quantum-size effect expected to be observed in Si quantum dots with a diameter of 50 Å.
Visible light photocatalysts—N-doped TiO2 by sol–gel, enhanced with surface bound silver nanoparticle islands (2011)

Antimicrobial thin film photocatalysts consisting of N-doped titania have been prepared by sol–gel methods and further enhanced using silver nanoparticles formed in situ on the surface of the films. The films have been characterised using XRD, SEM, XPS, UV-Visible spectroscopy and functionally tested using measurements for the photoinduced superhydrophilicity, stearic acid destruction and anti-microbial measurements using both E. coli and an epidemic strain of MRSA, EMRSA-16. The N-doped TiO2 films were seen to have interstitially doped nitrogen with the N 1s peak appearing at 400.0 eV in the XPS and as such showed good photocatalytic activity under white light. The photoactivity was then further enhanced by silver nanoparticle formations on the surface. The highly active photocatalytic films were seen to be effective agents against both bacteria and stearic acid using a white light source that is commonly found in UK hospitals.
Peptide variants reveal how antibodies recognize major histocompatibility complex class I (1993)

The T cell receptor (TcR) on CD8+ T lymphocytes recognizes a complex which consists of a major histocompatibility complex (MHC) heavy chain, beta 2-microglobulin (beta 2M), and peptide on the surface of antigen-presenting cells. Mutational analyses have suggested that the TcR recognizes both the alpha 1 and alpha 2 domains of the heavy chain as well as the peptide. In light of this, it is of interest to know to what extent the heavy chain domains take on distinct conformations when bound to individual peptides. It has recently been shown that antibodies which recognize the Kb MHC complex are sensitive to which peptides are bound in the groove. We have extended this analysis to include eight Kb-specific antibodies, seven of which are peptide sensitive. These antibodies, all of which are allo-antibodies, recognize Kb-bearing cells which, it is now appreciated, have a highly heterogeneous mix of self peptides presented in their grooves. We show that these self peptides also can affect antibody binding. It has been suggested that peptides alter the conformation of the alpha 1 and alpha 2 domains of the heavy chain and that this in turn affects the recognition of Kb by antibody. An alternative hypothesis is that solvent-exposed peptide side chains may prevent the antibody from binding the complex. Using a panel of 128 single-amino acid variants of a Kb-binding antigenic peptide from ovalbumin we show that for most Kb-specific antibodies, the second idea is more likely. Those variants which prevent antibody binding are at solvent exposed positions, and in general, the bulkier the side chain, the greater the inhibition of antibody binding. However, in the case of two antibodies, 100.30 and 34.4.20, the peptide residues which affect antibody recognition are buried, suggesting that these antibodies see an alternate conformation of the peptide/MHC complex.
Novel Force Matrix Transformations with Optimal Load-Balance for 3-body Potential based Parallel Molecular Dynamics in a Heterogeneous Cluster Environment (2007)

Evaluating the Force Matrix constitutes the most computationally intensive part of a Molecular Dynamics (MD) simulation. In three-body MD simulations, the total energy of the system is determined by the energy of every unique triple in the system and the force matrix is three-dimensional. The execution time of a three-body MD algorithm is thus proportional to the cube of the number of atoms in the system. Fortunately, there exist symmetries in the Force Matrix that can be exploited to improve the running time of the algorithm. While this optimization is straight forward to implement in the case of sequential code, it has proven to be nontrivial for parallel code even in a homogeneous environment. In this paper, we present two force matrix transformations that are capable of exploiting the symmetries in a 3-body force matrix in both a homogeneous and a heterogeneous environment while balancing the load among all the participating processors. The first transformation distributes the number of interactions to be computed uniformly among all the slices of the force matrix along any of the axes. The transformed matrix can be scheduled using any well known heterogeneous slice-level scheduling technique. The second transformation distributes interactions to be computed uniformly over the entire volume of the force matrix allowing us to perform a block decomposition of the force matrix. The transformed force matrix can be scheduled by any block level scheduling algorithm. We also derive theoretical bounds for efficiency and load balance for prior work in the literature. We then prove some interesting and useful properties of our transformations and evaluate their advantages and disadvantages. A loop reordering optimization for our transformations is also described. The performance of an MPI implementation of the transformations is studied in terms of the Step Time Variation Ratio (STVR) in a homogeneous and heterogeneous environment.
Solaris 10 : the complete reference (2000)

From the Book:
It's been an incredible journey for Sun Microsystems and its flagship operating system, Solaris. Sun released the first version of Solaris, based on a port of System V, release 4, in the early '90s and has built it into a truly world-class application platform, scaling from PCs to clusters of 64-way E10000s. Solaris was the first true assault on the glass-house mainframe world of proprietary architectures and astronomical prices. Every version has offered incremental improvements that keep Sun one step ahead of the competition-things like 64-bit processing, the journaling file system, great Java support, and network integration that is built in from the ground up. And this is where this book comes in. Solaris 8: The Complete Reference guides you through the rich functionality of Solaris with real-world examples and techniques for getting the most out of your Solaris machines. There's enough here to satisfy everyone, from the Solaris experts needing a reference to beginners looking for a guide to tackling this powerful, complex operating system. Spanning all the core areas of Solaris, Solaris 8: The Complete Reference is an indispensable tool for both administrators and users.
-Garrett Suhm
Editor, Inside Solaris
Advancing from offline to online activity recognition with wearable sensors (2008)

Activity recognition with wearable sensors could motivate people to perform a variety of different sports and other physical exercises. We have earlier developed algorithms for offline analysis of activity data collected with wearable sensors. In this paper, we present our current progress in advancing the platform for the existing algorithms to an online version, onto a PDA. Acceleration data are obtained from wireless motion bands which send the 3D raw acceleration signals via a Bluetooth link to the PDA which then performs the data collection, feature extraction and activity classification. As a proof-of-concept, the online activity system was tested with three subjects. All of them performed at least 5 minutes of each of the following activities: lying, sitting, standing, walking, running and cycling with an exercise bike. The average second-by-second classification accuracies for the subjects were 99%, 97%, and 82 %. These results suggest that earlier developed offline analysis methods for the acceleration data obtained from wearable sensors can be successfully implemented in an online activity recognition application.
Clinical neurosurgery as it relates to the lumbar spine (1991)

Neurosurgeons may derive as much as 62% of their professional income from and perform proportionately as large a number of procedures on the lumbar spine. Publications in neurosurgical journals, presentations at national and international neurosurgical meetings, and participation in organized neurosurgical symposia are, however, relatively sparse in this area of activity. It appears, therefore, that the lumbar spine must have minimal academic interest to neurosurgeons, as compared with the surgical areas where they have clinical domain, i.e., the brain and spinal cord. In that this clear discrepancy between what they do (their source of income) and what they talk about and publish is apparently not well known to neurosurgeons or their professional society directors, this paper is presented as objective, awakening evidence. The potential impact on future patient draw, professional prowess, and income, which may result from a continuation of this wide gap, is also discussed.
Dip‐dependent corrections for data reconstruction in true‐azimuth 3D SRME (2010)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2010Dip‐dependent corrections for data reconstruction in true‐azimuth 3D SRMEAuthors: Peter AaronRoald van BorselenRob HeggeSimon BarnesPeter AaronPGS, Roald van BorselenPGS, Rob HeggePGS, and Simon BarnesPGShttps://doi.org/10.1190/1.3513557 SectionsSupplemental MaterialAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract This paper presents a method to apply dip‐dependent azimuth, midpoint and offset corrections during the data reconstruction in True‐azimuth 3D Surface‐related multiple Elimination (TA 3D SRME). The method is applied to synthetic examples and a field dataset. Comparisons are made with a TA 3D SRME which uses a more conventional differential Normal Move‐Out (NMO) reconstruction, with no additional corrections. Results show that the new method is capable of correcting for primaries, diffractions, multiples and diffracted multiples. It is demonstrated that correcting for azimuth, midpoint and offset effects using geological constraints during the data reconstruction, can significantly improve the prediction of multiples in the presence of complex 3D events, such as diffracted multiples.Permalink: https://doi.org/10.1190/1.3513557FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 2010ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2010 Pages: 4453 publication data© 2010 Copyright © 2010 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 21 Oct 2010 CITATION INFORMATION Peter Aaron, Roald van Borselen, Rob Hegge, and Simon Barnes, (2010), "Dip‐dependent corrections for data reconstruction in true‐azimuth 3D SRME," SEG Technical Program Expanded Abstracts : 3411-3415. https://doi.org/10.1190/1.3513557 Plain-Language Summary PDF DownloadLoading ...
A Hough transform-based voting framework for action recognition (2010)

We present a method to classify and localize human actions in video using a Hough transform voting framework. Random trees are trained to learn a mapping between densely-sampled feature patches and their corresponding votes in a spatio-temporal-action Hough space. The leaves of the trees form a discriminative multi-class codebook that share features between the action classes and vote for action centers in a probabilistic manner. Using low-level features such as gradients and optical flow, we demonstrate that Hough-voting can achieve state-of-the-art performance on several datasets covering a wide range of action-recognition scenarios.
On-set performance capture of multiple actors with a stereo camera (2013)

State-of-the-art marker-less performance capture algorithms reconstruct detailed human skeletal motion and space-time coherent surface geometry. Despite being a big improvement over marker-based motion capture methods, they are still rarely applied in practical VFX productions as they require ten or more cameras and a studio with controlled lighting or a green screen background. If one was able to capture performances directly on a general set using only the primary stereo camera used for principal photography, many possibilities would open up in virtual production and previsualization, the creation of virtual actors, and video editing during post-production. We describe a new algorithm which works towards this goal. It is able to track skeletal motion and detailed surface geometry of one or more actors from footage recorded with a stereo rig that is allowed to move. It succeeds in general sets with uncontrolled background and uncontrolled illumination, and scenes in which actors strike non-frontal poses. It is one of the first performance capture methods to exploit detailed BRDF information and scene illumination for accurate pose tracking and surface refinement in general scenes. It also relies on a new foreground segmentation approach that combines appearance, stereo, and pose tracking results to segment out actors from the background. Appearance, segmentation, and motion cues are combined in a new pose optimization framework that is robust under uncontrolled lighting, uncontrolled background and very sparse camera views.
Living, Isoselective Polymerization of Styrene and Formation of Stereoregular Block Copolymers via Sequential Monomer Addition (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTLiving, Isoselective Polymerization of Styrene and Formation of Stereoregular Block Copolymers via Sequential Monomer AdditionAntonio Proto*, Antonietta Avagliano, Daniela Saviello, Rosa Ricciardi, and Carmine Capacchione*View Author Information Dipartimento di Chimica, and NANOMATES, Research Centre for NANOMAterials and nanoTEchnology at Università di Salerno, via Ponte don Melillo, I-84084 Fisciano, Salerno, Italy*To whom correspondence should be addressed. E-mail: [email protected] (A.P.); [email protected] (C.C.).Cite this: Macromolecules 2010, 43, 14, 5919–5921Publication Date (Web):June 30, 2010Publication History Received20 April 2010Published online30 June 2010Published inissue 27 July 2010https://pubs.acs.org/doi/10.1021/ma101246xhttps://doi.org/10.1021/ma101246xrapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views1162Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Butadiene,Copolymerization,Copolymers,Monomers,Styrenes Get e-Alerts
Kinetics of Acid-Catalyzed Cleavage of Procyanidins (1983)

Abstract Comparisons of the rates of cleavage of isomeric procyanidin dimers in the presence of excess phenylmethane thiol and acetic acid showed that compounds with a C(4)–C(8) interflavanoid bond were cleaved more rapidly than their C(4)–C(6) linked isomers, that 2,3-cis isomers with an axial flavan substituent were cleaved more rapidly than a 2,3-trans isomer with an equatorial substituent, and that cleavage rate was independent of the stereochemistry in the terminal unit. Cleavage rate constants followed Arrhenius temperature dependence. The C(4)–C(8) interflavanoid bond in 2,3-cls procyanidins should be labile to cleavage at 20°C over a pH range of 3.6 to 5.4. Reaction of loblolly pine bark tannins in the presence of excess (+)-catechin with acetic acid rapidly produced oligomeric procyanidins. The ratio of the procyanidin Bl to B7 decreased from 2.9:1 after 4 hours to 1.3:1 after 50–100 hours at 90°C. The structure and reactions of condensed tannins are interpreted in light of these results.
Observation of long photoluminescence decay times for high-quality GaN grown by metalorganic chemical vapor deposition (2000)

GaN epitaxial layers with different crystalline quality grown on sapphire substrates by metalorganic chemical vapor deposition are investigated using time-resolved photoluminescence at 300 K. It is found that the time-dependent photoluminescence of low-quality GaN decays faster than that of the high-quality GaN films. The time constants for the dual-exponential decay of the photoluminescence are calculated to be 50 and 250 ps for high-quality undoped GaN and 30 ps for low-quality undoped GaN. For high-quality Si-doped GaN, time constants of 150 and 740 ps are extracted while corresponding time constants of 40 and 200 ps are measured for low-quality Si-doped GaN. We believe that the time constant of 740 ps measured for our high-quality Si-doped GaN is the longest ever reported for thin GaN/sapphire films.
New approach for determining the normal of the bow shock based on Cluster four‐point magnetic field measurements (2007)

We introduce a new approach to determine the normal of Earth’s bow shock, based on four‐point magnetic field measurements. The method obtains the local bow shock normal, based on the assumption that the normal is in the opposite direction to the gradient of the magnetic pressure or magnetic strength (within the shock front). This gradient can be deduced from the four‐point magnetic field measurements of Cluster. Applying the method, we calculate the normal of the bow shock for 28 Cluster crossing events from March to April of 2002 and February to March of 2004 and compare the results for the boundary orientation to commonly known methods, i.e., minimum variance analysis and the coplanarity theorem. In addition, we compare results of the normal obtained by four spacecraft timing analysis, under the assumptions of local planarity and constant velocity of the boundary (triangulation). It is known that minimum variance analysis often fails because of the temporal variation of the bow shock and coplanarity analysis often fails because of the existence of an overshoot or poor determination of the downstream magnetic field due to plasma disturbance. We find that the gradient analysis agrees most closely with the timing analysis, and, in general, the shock orientations obtained fit the expected bow shock geometry. The gradient method is valid for quasi‐stable shocks and does not require the conditions of coplanarity or constant velocity of the bow shock to be satisfied. Its accuracy depends on this stability and the relative spatial scale of the shock, which should be large compared to the spacecraft configuration. A feature of the method, however, is that it provides an estimate of the normal point by point in time, allowing the nature of the spacecraft sampling to be monitored in terms of behavior as each shock event is traversed.
Synthesis of 1-acyl-2-oxo-3-pyrrolidinecarbonitriles by the reaction of 2-acylamino-4,5-dihydro-3-furancarbonitriles with sodium iodide (2005)

The reaction of 2-acylamino-4,5-dihydro-3-furancarbonitriles 1 with sodium iodide in N,N-dimethyl-formamide gave the corresponding 1-acyl-2-oxo-3-pyrrolidinecarbonitriles 2 in good yields. Successive treatment of 1 with titanium(IV) chloride and potassium carbonate resulted in the formation of N-acyl-1-cyanocyclopropanecarboxamides 4. The same compounds 2 were also obtained by treatment of 4 with sodium iodide. The starting compounds 1 were synthesized by the reaction of 2-amino-4,5-dihydro-3-furan-carbonitrile with acyl chlorides in pyridine.