gebhart/patrepeval huggingface dataset:
Multistep reactions: the RABBIT approach (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultistep reactions: the RABBIT approachAlexander J. Lawson and Hartmut KalliesCite this: J. Chem. Inf. Comput. Sci. 1990, 30, 4, 426–430Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ci00068a013https://doi.org/10.1021/ci00068a013research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Software Approach to Defeating Side Channels in Last-Level Caches (2016)

We present a software approach to mitigate access-driven side-channel attacks that leverage last-level caches (LLCs) shared across cores to leak information between security domains (e.g., tenants in a cloud). Our approach dynamically manages physical memory pages shared between security domains to disable sharing of LLC lines, thus preventing "Flush-Reload" side channels via LLCs. It also manages cacheability of memory pages to thwart cross-tenant "Prime-Probe" attacks in LLCs. We have implemented our approach as a memory management subsystem called CacheBar within the Linux kernel to intervene on such side channels across container boundaries, as containers are a common method for enforcing tenant isolation in Platform-as-a-Service (PaaS) clouds. Through formal verification, principled analysis, and empirical evaluation, we show that CacheBar achieves strong security with small performance overheads for PaaS workloads.
Recent developments in cellulose solvent systems (1984)

Comparaison de l'utilisation, des avantages et limites des amines oxydes, ammoniac liquide avec un sel d'ammonium, et LiCl avec le dimethylacetamide comme trois des systemes solvants les plus recemment decrits
Isolation and characterization of Streptococcus mutans in heart valve and dental plaque specimens from a patient with infective endocarditis (2006)

Streptococcus mutans, known to be an aetiologic agent of dental caries, also causes infective endocarditis (IE), although a comparison of isolates from the oral cavity and infected heart valve of the same patient has not been reported. In the present study, infected heart valve and dental plaque samples from a patient with IE were analysed. Broad-range PCR with DNA sequencing revealed that 50 clones from the dental plaque isolates were composed of oral streptococci and periodontopathic bacteria, whereas only Streptococcus mutans was detected in 50 clones from the heart valve. Eighteen strains of Streptococcus mutans were isolated from dental plaque and seven from the heart valve, and the biochemical properties of each were in accordance with those of Streptococcus mutans. DNA fingerprinting analysis revealed that all the oral isolates of Streptococcus mutans had similar patterns, which were different from those of the isolates from the infected heart valve. Western blotting using glucosyltransferase (GTF)-specific antiserum showed that the seven strains from the heart valve lacked the three types of intact GTF. In addition, the sucrose-dependent adhesion rates of these isolates were significantly lower than those of the oral isolates (P<0.001). Furthermore, the isolates from the heart valve were less susceptible to erythromycin and kanamycin. These results indicate that the properties of the Streptococcus mutans strains isolated from the infected valve were different from those of typical oral strains, which may be related to the effects of IE.
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease (2014)

Recent advances in defining the genetic mechanisms of disease causation and modification in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some extreme disease manifestations and other phenotypic variability. Studies of the ADPKD proteins, polycystin-1 and -2, and the development and characterization of animal models that better mimic the human disease, have also helped us to understand pathogenesis and facilitated treatment evaluation. In addition, an improved understanding of aberrant downstream pathways in ADPKD, such as proliferation/secretion-related signaling, energy metabolism, and activated macrophages, in which cAMP and calcium changes may play a role, is leading to the identification of therapeutic targets. Finally, results from recent and ongoing preclinical and clinical trials are greatly improving the prospects for available, effective ADPKD treatments.
Effect of probabilistic error checking procedures and performability of robust objects (1993)

The paper develops a Markov reward model for the per- formability analysis of robust objects having single error correcting capabilities.
Ferroelectric Phase Diagram of PVDF:PMMA (2012)

We have investigated the ferroelectric phase diagram of poly(vinylidene fluoride) (PVDF) and poly(methyl methacrylate) (PMMA). The binary nonequilibrium temperature composition diagram was determined and melting of α- and β-phase PVDF was identified. Ferroelectric β-PVDF:PMMA blend films were made by melting, ice quenching, and subsequent annealing above the glass transition temperature of PMMA, close to the melting temperature of PVDF. Addition of PMMA suppresses the crystallization of PVDF and, as a consequence, the roughness of blend films was found to decrease with increasing PMMA content. Using time-dependent 2D numerical simulations based on a phase–field model, we qualitatively reproduced the effect of PMMA on the crystallization rate and the spherulite shape of PVDF. The remnant polarization scaled with the degree of crystallinity of PVDF. The thermal stability of the polarization is directly related to the Curie temperature. We show that, at high temperature, the commodity ferroelectric PVDF:PMMA blends outperform the commonly employed specialty copolymer poly(vinylidene fluoride–trifluoroethylene) (P(VDF–TrFE)).
Nondestructive evaluation of wires using high-temperature SQUIDs (1999)

A method using SQUID magnetometry and low-frequency current injection has been developed to detect defects during the fabrication of single and multi-strand wire, especially superconductive NbTi/Cu wire.
Actin-Binding Proteins from <i>Burkholderia mallei</i> and <i>Burkholderia thailandensis</i> Can Functionally Compensate for the Actin-Based Motility Defect of a <i>Burkholderia pseudomallei bimA</i> Mutant (2005)

Recently we identified a bacterial factor (BimA) required for actin-based motility of Burkholderia pseudomallei. Here we report that Burkholderia mallei and Burkholderia thailandensis are capable of actin-based motility in J774.2 cells and that BimA homologs of these bacteria can restore the actin-based motility defect of a B. pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3.
Treatment of tinea unguium with medium and high doses of ultramicrosize griseofulvin compared with that with itraconazole (1993)

Toenail tinea is a very recalcitrant dermatosis. Griseofulvin at > or = 500 mg/day is the current medication of choice, but it is minimally successful. In a controlled open trial ultramicrosize griseofulvin (UMSG) at doses of 660 and 990 mg/day was compared with itraconazole at 100 mg/day in 109 patients. At 4-week intervals, the patients were evaluated for their clinical and mycological statuses and adverse reactions. Treatment was given for up to 18 months. Compliance was checked by tablet counting. Response (cure, partial cure, marked improvement) was analyzed by the intent-to-treat method. Cured and partially cured patients were followed up. Except for one early dropout, the toenails (mean, 6 to 7) were involved. Cure or partial cure was found in 6% (UMSG at 660 mg), 14% (UMSG at 990 mg), and 19% (itraconazole at 100 mg) of patients (P = 0.2097); marked improvement was found in 36, 44, and 39% of patients in the three treatment groups, respectively. Most patients had to be treated for 18 months. Failure was related to short medication periods (adverse drug reactions, dropout). While stable cure was not obtained with UMSG at 660 mg, the higher dose of UMSG and itraconazole gave stable cures in the other patients. Side effects of nausea, diarrhea, and headache were found in 20, 26, and 11 patients, respectively (P = 0.0028), and the numbers in whom medication had to be discontinued differed, too (P = 0.0137). While there was no major difference with glutamic-pyruvic transaminase and gamma-GT, total and low-density lipoprotein cholesterol levels declined slightly in the itraconazole group (P = 0.0357 and P = 0.0639, respectively, at 3 months). More than 70% of the patients had an average compliance of > or = 90%; four patients (two dropouts) were poor compliers. In conclusion, it appears questionable whether griseofulvin can continue to be considered the "gold standard" in the treatment of toenail tinea. At present, itraconazole at 100 mg shows better efficacy and is better tolerated.
A Secure and Robust Authentication Scheme for Video Transcoding (2006)

In this paper, we describe a configurable content-based MPEG video authentication scheme, which is robust to typical video transcoding approaches, namely frame resizing, frame dropping and requantization. By exploiting the synergy between cryptographic signature, forward error correction (FEC) and digital watermarking, the generated content-based message authentication code (MAC or keyed crypto hash) is embedded back into the video to reduce the transmission cost. The proposed scheme is secure against malicious attacks such as video frame insertion and alteration. System robustness and security are balanced in a configurable way (i.e., more robust the system is, less secure the system will be). Compressed-domain process makes the scheme computationally efficient. Furthermore, the proposed scheme is compliant with state-of-the-art public key infrastructure. Experimental results demonstrate the validity of the proposed scheme
Opposing Actions of BMP3 and TGFβ1 in Human Bone Marrow Stromal Cell Growth and Differentiation (1997)

BMP3 and TGF beta 1 were found to induce opposite effects on human bone marrow stromal cells both in cell proliferation and cell differentiation and on calcium deposition onto the extracellular matrix. Moreover, BMP3 may exert, in part, the inhibitory effect of TGF beta 1 through decreasing the affinity of TGF-beta for its receptors which are now identified in these human bone cells.
Framework for Flexural Rigidity Estimation in Euler-Bernoulli Beams Using Deformation Influence Lines (2017)

Structural degradation is an inevitable part of a structure’s service life. Detecting structural impairments and assessing their nature is a significant challenge. Degradations reduce structural system stiffness and subsequently affect system deformations. An appropriate structural health index that is able to capture these changes in deformation and relate them to a structural system stiffness may help engineers to adequately rate structural condition. This paper outlines a theoretical framework for the utilization of static deformation influence lines for estimating the flexural rigidity of Euler-Bernoulli beams. In the proposed technique, the relationship between the second derivative of the deformation influence line and the flexural rigidity for both statically determinate and indeterminate beam structures is presented. The proposed method provides a flexural rigidity estimate (FRE) over the entire span that is based on a single measurement location and estimates both the location and severity of impairments, regardless of the location of the measurement or the damaged zones. Noisy analytical simulations are presented with noise levels of 0%, 0.5%, 1%, 2%, 3%, and 4%; in all cases the modeled damage is quantified and localized using the FRE. A laboratory experiment is also presented that validates the theoretical framework.
Circumvention of P-glycoprotein-mediated Multiple Drug Resistance by Phosphorylation Modulators Is Independent of Protein Kinases (1995)

Expression of P-glycoprotein by tumor cells confers resistance to multiple natural product drugs because of its ability to export these compounds. This transporter is a substrate for several protein kinases; however, the functional significance of its phosphorylation is not defined. We examined the effects of many activators and inhibitors of protein kinases on the activity of P-glycoprotein in drug-resistant human breast carcinoma cells (MCF-7/ADR). Several phorbol esters sensitized these cells to P-glycoprotein substrate drugs; however, there was no correlation with activation of protein kinase C. The 4 alpha- and 4 beta-isomers of phorbol 12-myristate 13-acetate were equally potent in sensitizing the cells to actinomycin D and daunomycin and in increasing the intracellular accumulation of [3H]vinblastine. These effects of 4 beta-phorbol myristate acetate required much higher concentrations than were needed to increase P-glycoprotein phosphorylation and were not antagonized by staurosporine. Similar to verapamil, the phorbol esters did not sensitize MCF-7/ADR cells to cisplatin, nor parental MCF-7 cells to any of the anticancer drugs. Mezerein, K-252a, and H-89 sensitized MCF-7/ADR cells, increased intracellular accumulation of [3H]vinblastine, and antagonized photolabeling of P-glycoprotein by [3H]azidopine. Therefore, phosphorylation does not appear to play a significant role in regulating P-glycoprotein activity in MCF-7/ADR cells.
Characteristics of AlN crystal growth depending on m‐ and a‐axis oriented off‐angle of c‐sapphire substrate (2012)

Abstract For the achievement of high‐efficiency AlGaN‐based deep‐ultraviolet (DUV) light‐emitting diodes (LEDs), we investigated the characteristics of AlN crystal growth depending on m‐ and a‐axis oriented off‐angle of c‐sapphire substrate. In order to reduce threading dislocation density (TDD) in AlN crystal growth, we used ammonia (NH 3 ) pulse‐flow multilayer (ML) growth technique in the metal‐organic chemical vapor phase deposition (MOCVD). We found that a macrostep geometry (large step‐bunching) is generated on the surface of AlN template grown on m‐axis oriented (0001) sapphire substrate. On the other hand, macrostep‐free surface can be obtained for AlN grown on a‐axis oriented sapphire. We also found that cracks are easier generated in AlN grown on a‐axis oriented sapphire. It is considered that step‐flow growth is easily obtained for the growth of a‐axis oriented case due to that the atom site of the step edge in the growth is more stable. On the other hand, for m‐axis oriented case, step‐bunching is considered to occur because atoms are easily drifted during the growth due to that the atom site of the edge steps are more unstable. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia. (2005)

Microarray technology not only allows the distinction between disease subclasses but also offers a chance to identify new genes involved in leukemogenesis. Our approach of using a unique platform has proven to be fruitful in identifying new genes and we suggest exploration of other malignancies using this approach.
Efficient video resolution adaptation using scalable H.265/HEVC (2013)

Dynamically changing the spatial resolution in a video conferencing session is useful for seamlessly adapting the bitrate to changing network conditions and for improving the user experience. Similar to earlier standards, the emerging High Efficiency Video Coding (H.265/HEVC) standard does not allow prediction across different resolutions, so an Instantaneous Decoding Refresh (IDR) picture must be sent to reinitialize the stream when a resolution change happens. IDR pictures take significantly more bits compared to predictively coded pictures. Thus, using them for resolution switching significantly reduces coding efficiency and increases the delay. In this paper we propose a method to support efficient adaptive resolution change using the emerging scalable H.265/HEVC standard. The proposed approach utilizes the inter-layer predicted random access pictures at the enhancement layer for resolution switching, instead of IDR pictures. The experimental results show that when the proposed method was used, the bitrate was reduced at the switching point by 34% on average for the tested video sequences. In addition, visual examples are shown demonstrating the improved visual quality with the proposed method.
Über Mercaptotetrazole (1932)

Journal für Praktische ChemieVolume 133, Issue 1-2 p. 60-64 Mitteilung aus dem Chemischen Institut der Universität Heidelberg Über Mercaptotetrazole R. Stollé, R. StolléSearch for more papers by this author R. Stollé, R. StolléSearch for more papers by this author First published: Januar 1932 https://doi.org/10.1002/prac.19321330106Citations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume133, Issue1-2Januar 1932Pages 60-64 RelatedInformation
Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs. (1987)

The isolation of mutant cell lines affecting the activity of cyclic AMP (cAMP)-dependent protein kinase (PK-A) has made it possible to determine the function of this kinase in mammalian cells. We found that both a CHO cell mutant with a defective regulatory subunit (RI) for PK-A and a transfectant cell line expressing the same mutant kinase were sensitive to multiple drugs, including puromycin, adriamycin, actinomycin D, and some antimitotic drugs. The mutant and transfectant cells, after treatment with a concentration of the antimitotic drug colcemid that had no marked effect on the wild-type parent cell, had a severely disrupted microtubule network. The phenotype of hypersensitivity to the antimitotic drug colcemid was used to select revertants of the transfectant and the original mutant. These revertants simultaneously regained normal multiple drug resistance and cAMP sensitivity, thus establishing that the characteristics of colcemid sensitivity and cAMP resistance are linked. Four revertants of the transfectant reverted because of loss or rearrangement of the transfected mutant RI gene. These revertants, as well as one revertant selected from the original mutant, had PK-A activities equal to or higher than that of the parent. In these genetic studies, in which linkage of expression of a PK-A mutation with drug sensitivity is demonstrated, it was established that the PK-A system is involved in regulating resistance of mammalian cells to multiple drugs.
Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation (2001)

A novel chemical modification of biological tissues was developed aimed at improving biocompatibility and calcification resistance. This method involved the additional grafting of sulfonated PEO (PEO-SO(3)) or heparin after conventional glutaraldehyde (GA) fixation of bovine pericardium (BP). The amino groups of PEO-SO(3) or heparin were utilized to react to the GA residues to block them. The PEO-SO(3) or heparin grafted tissues demonstrated a slightly higher shrinkage temperature and tensile strength, but greater resistance to collagenase digestion, than GA treated ones. These results suggest that modified tissues have improved durability due to the grafting and filling effect of PEO-SO(3) or heparin in addition to the GA cross-linking. At the direct contact cytotoxicity test in vitro, PEO-SO(3) or heparin grafted tissue was shown to be nontoxic, while relatively significant cytotoxicity was observed for the GA treated tissues, possibly due to the release of GA. From the in vivo calcification study, calcium contents deposited on the modified tissues were much less than those on GA treated tissues. Such a decreased calcification might be explained by the decrease of residual GA groups during the additional treatment, and the space-filling effect and the nonadhesive property and/or the blood compatibility of PEO-SO(3) or heparin grafted covalently. The newly modified tissue patch was observed to show improved pathological assessibility including less inflammation and tissue reactions. This simple modification method may be useful for calcification-resistant and blood-compatible tissue patches for cardiovascular implants.
Superconductivity and crystallinity of Ba2Y1Cu3O7−δ thin films prepared by pulsed laser deposition with substrate bias voltage (1990)

Substrate bias voltages were found to be significantly effective in preparing high-quality laser-deposited superconducting Ba2Y1Cu3O7−δ films at reduced substrate temperatures. The zero-resistance temperature of the biased films, positive bias being more effective than negative, decreased very slightly when the substrate temperature was lowered, whereas that of the unbiased films decreased considerably. In addition, the surface morphology and c-axis orientation have been improved by applying substrate bias voltages. Bias voltages within ±500 V hardly affect the composition of the resulting films so that stoichiometric films have been obtained from a stoichiometric target. A time-resolved optical observation revealed that a short time emission, probably being oxygen plasma, occurred in a few μs after the laser pulse impingement. The improvement in crystallinity of the resulting films is attributed to this emission. The velocity of emissive species in the plume was determined to be 6×105 cm/s. Under positive-biased conditions slower components with a velocity of 3×105 cm/s or less were also observed.