gebhart/patrepeval huggingface dataset:
ELİT ERKEK HENTBOLCULARDA HAZIRLIK DÖNEMİ ÖNCESİ, HAZIRLIK DÖNEMİ SONRASI VE MÜSABAKA DÖNEMİ SONRASI DÖNEMLER ARASINDA MAKSİMAL LAKTİK ASİT VE ANAEROBİK EŞİK DEĞİŞİM DÜZEYLERİ (2002)

Bu calismanin amaci; elit erkek hentbolcularda hazirlik donemi oncesi (1), hazirlik donemi sonrasi (2) ve musabaka donemi sonrasi (3) maksimal laktik asit ve anaerobik esik degisim duzeylerinin arastirilmasidir. Calismaya 1. ligden yas ortalamalari 25.71±3.55 olan, 7 erkek hentbolcu gonullu denek olarak katilmislardir. Deneklerin maksimal laktat ve anaerobik esik degerleri kosu bandinda (treadmill) tespit edilmistir. Sporcularinn vucut yag oranlari, 3 bolgeden (gogus, karin ve uyluk ) alinan deri kivrim kalinliklari Jackson and Pollack yontemine gore hesaplanmistir. Elde edilen verilerin aritmetik ortalamalari, standart sapmalari ve olcumler arasindaki farkliliklar Repeated Measures Analysis of Variance (REPEATED ANOVA) testi ile p<0.05 anlamlilik derecesinde hesaplanmistir. Ayrica veriler aralarinda farklilik var ise bu farkliligin hangi donemlerden kaynaklandigi TUKEY HSD testi ile belirlenmistir. Arastirma sonucunda sporcularda laktat’in kanda 4 Mmol oldugu AE Hiz ve AE KAH degerlerinde ve Max LA degerlerinde hazirlik donemi oncesi, hazirlik donemi sonrasi ve musabaka donemi sonrasi donemler arasinda istatistiksel olarak anlamli fark tespit edilmemistir. Sporcularin, hazirlik donemi oncesi, hazirlik donemi sonrasi ve musabaka donemi sonrasi donemlerde VYO, VK‹ (p<0.05), Agirlik ve Maks.KAH (p<0.01) degerlerindeki degisim duzeylerinde istatistiksel olarak anlamli fark tespit edilmistir. Farkin tespit edildigi donemler VYO icin hazirlik donemi oncesi ve hazirlik donemi sonrasi (1-2 donemler) donemleri arasindadir. VK‹, Maks. KAH ve Agirlik icin ise hazirlik donemi oncesi ve hazirlik donemi sonrasi donemleri (1-2 donemler) ile hazirlik donemi sonrasi donem ve musabaka donemi sonrasi donemler (2-3 donemler) arasindadir.
Communicating with a large customer base via mobile messaging (2011)

The widespread use of mobile phones has opened up new ways of communicating with large numbers of people. Companies can use personalized SMS messages as a fast and cost-efficient means of providing customers with information and receiving immediate feedback. In this paper the design, development, and use of a mobile marketing platform is described both from a technical and a user-experience point of view. Solutions are presented which allow fast and reliable sending of large numbers of messages. A central event processing mechanism has been implemented which reacts to incoming messages and processes notifications received from external systems. Timer-based services perform regular tasks like sending informative messages to customers and business users of the platform. Customer data is managed with automated registration and deregistration, data exchange with external systems, selection of destination groups based on user attributes, and the collection of a comprehensive history of customer interactions. Intelligent supervising tasks which automatically recognize exceptional conditions like unusually large message quantities within a specified time frame are performed in the background. An administrative web interface of the platform with comprehensive message monitoring functions allows taking appropriate action in such cases. After describing this and other unique features, experience from development and practical applications of the platform is presented which allows evaluating the project and summarizing the lessons learned during five years of development and deployment of the platform.
Airbag Bumpers Inflated Just Before the Crash (1994)

<div class="htmlview paragraph">Bumpers have lost their important functions of crash load isolation and inter-vehicle compatibility. Occupant compartment protection has been shifted to collapse of surrounding structures, with vehicle inoperability and occupant injury not unusual after a 50 km/h barrier impact. For higher speed vehicle and occupant survivability, a larger crash stopping distance is needed - provided by bumpers extended by radar sensing of need just before the crash.</div> <div class="htmlview paragraph">The hydraulic extended bumper was first developed by Professor James Ryan, giving vehicle driveability after a 40 km/h barrier crash, and further developed worldwide in the Experimental Safety vehicle programs, but unfortunately never developed for the commercial market.</div> <div class="htmlview paragraph">Our current work is to demonstrate the potential of compartmented airbag bumper systems inflated just before the crash to cover 1 square meter on the crash surface. The airbags would be inflated to extend out 0.6 m on the front, or 0.3 m on the rear or either side, or 0.15 m on the roof. The airbags could sustain up to 700 kilopascals peak loads when compressed. In a frontal crash, this is enough to decelerate a 1300 kg car at -25 Gx peak and remove 40 km/h equivalent energy from the crash event, leaving collapse of the hood, trunk, or doors for higher speed survivability. Preliminary swing crash tests are presented, along with a discussion of needed car load path changes.</div>
Al(OTf)<sub>3</sub>-Mediated Epoxide Ring-Opening Reactions: Toward Piperazine-Derived Physiologically Active Products (2009)

Al(OTf)(3) is a good catalyst for the ring opening of epoxides, forming beta-amino alcohols bearing the piperazine motif. Two different strategies were examined, where the glycidyl ether resided on one-half of the molecule or the other, allowing insight into a best-case approach for the ring-opening step. Each half of the molecule contained an heteroatom that could be used either to attach the glycidyl moiety or as the nucleophile in the ring-opening reaction, for the same set of reagents, allowing this approach.
Reinventing high density area departure traffic management (2011)

As a complex dynamic system, today's National Airspace System (NAS) can be very sensitive to disruptive events. High density area departure management is particularly sensitive to such disruptions. This paper builds upon previous research that proposes an operational concept to ensure safe, efficient, and stable departure traffic management in the Next Generation Air Transportation System. This research first proposes the proper roles and responsibilities of Traffic Management Coordinators (TMCs) in different facilities and then defines the functions/capabilities needed to support the roles and responsibilities identified. This paper models, simulates, and compares the performance of the proposed operation with today's operation. The sensitivity of the proposed operation to events like over-head flow constraints is also examined and compared with today's operation. The results reveal that the proposed concept provides performance enhancements and system stability in response to disruption.
Coordination Arrays: Tetranuclear Cobalt(<scp>II</scp>) Complexes with [2 × 2]‐Grid Structure (1997)

The use of two tridentate ligands is the secret of success for the self-assembly of structurally intriguing tetranuclear CoII complexes. The cation [Co4(L)4]8+ (1) exists as a [2 × 2]-grid of octahedrally coordinated metal ions located at the corners of a square. The complex displays multiple redox processes and is of potential redox processes and is of potential interest for the development of electrochemically addressable inorganic arrays (R1, R2 = H, Me; • = CoII).
High-mobility, sputtered films of indium oxide doped with molybdenum (2004)

Thin films of molybdenum-doped indium oxide, an n-type transparent conducting oxide, were deposited on glass substrates by a large-area deposition technique, radio-frequency magnetron sputtering, and their electrical properties were examined. Molybdenum content was varied from 1 to 4 wt%, and the highest mobility achieved was 83 cm2 V−1 s−1 at a carrier concentration of 3.0×1020 cm−3 without any postdeposition treatment for one of the films made from the target with 2 wt% Mo. Temperature-dependent Hall analysis indicated that this high mobility is limited by phonon scattering, whereas the method of four coefficients analysis showed that the conduction band is parabolic.
Evolutionary redesign of the lysosomal enzyme arylsulfatase A increases efficacy of enzyme replacement therapy for metachromatic leukodystrophy (2019)

Protein engineering is a means to optimize protein therapeutics developed for the treatment of so far incurable diseases including cancers and genetic disorders. Here we report on an engineering approach in which we successfully increased the catalytic rate constant of an enzyme that is presently evaluated in enzyme replacement therapies (ERT) of a lysosomal storage disease (LSD). Although ERT is a treatment option for many LSDs, outcomes are lagging far behind expectations for most of them. This has been ascribed to insufficient enzyme activities accumulating in tissues difficult to target such as brain and peripheral nerves. We show for human arylsulfatase A (hARSA) that the activity of a therapeutic enzyme can be substantially increased by reversing activity-diminishing and by inserting activity-promoting amino acid substitutions that had occurred in the evolution of hominids and non-human mammals, respectively. The potential of this approach, here designated as evolutionary redesign, was highlighted by the observation that murinization of only 1 or 3 amino acid positions increased the hARSA activity 3- and 5-fold, with little impact on stability, respectively. The two kinetically optimized hARSA variants showed no immunogenic potential in ERT of a humanized ARSA knockout mouse model of metachromatic leukodystrophy (MLD) and reduced lysosomal storage of kidney, peripheral and central nervous system up to 3-fold more efficiently than wild-type hARSA. Due to their safety profile and higher therapeutic potential the engineered hARSA variants might represent major advances for future enzyme-based therapies of MLD and stimulate analogous approaches for other enzyme therapeutics.
Reactivity of Ionic Liquids (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Does α‐MSH Have a Role in Regulating Skin Pigmentation in Humans? (1998)

Over the years there has been much debate as to whether alpha-MSH has a role as a pigmentary hormone in humans. There are two main reasons for this. First, despite the observations in the 1960s that alpha-MSH increased skin darkening in humans, there are reports that the peptide has no effect on melanogenesis in cultured human melanocytes. Second, the human pituitary, unlike that of most mammals, secretes very little alpha-MSH and circulatory levels of the peptide in humans are extremely low. However, there is now evidence from several groups that alpha-MSH is capable of stimulating melanogenesis in cultured human melanocytes. Rather than producing an overall increase in melanin production, it appears that the peptide acts specifically to increase the synthesis of eumelanin. Such an action could well explain the previously observed skin darkening effects of alpha-MSH. It is also now known that alpha-MSH is not produced exclusively in the pituitary but has been found at numerous sites, including the skin where it is produced by several cell types. Related Proopiomelanocortin (POMC) peptides such as ACTH are also produced in human skin. The ACTH peptides act at the same receptor (MC-1) as alpha-MSH and certain of these would appear to be more potent than alpha-MSH in stimulating melanogenesis. The ACTH peptides are also present in greater amounts than alpha-MSH in human epidermis and it is likely that they play an important role in regulating pigmentary responses. These POMC peptides are released from keratinocytes in response to ultraviolet radiation (UVR) and it has been proposed that they serve as paracrine factors in mediating UV induced pigmentation. Their production by keratinocytes could therefore be critical in determining pigmentary responses and any changes in the availability of these POMC peptides might explain the variations in tanning ability seen in different individuals. However, the possibility that tanning ability is also dependent upon differences at the level of the MC-1 receptor cannot be ruled out and it has been suggested that an inability to tan may depend upon the presence of non-functional changes at the MC-1 receptor. alpha-MSH does, of course, affect human melanocytes in several ways and its stimulation of melanogenesis could be the consequence of some other fundamental action in the melanocyte. The peptide also has many other target sites in the skin and while it may have a role in regulating skin pigmentation in humans, it should not be viewed solely as a pigmentary peptide. alpha-MSH clearly has many different actions and its primary role in the skin may be to maintain homeostasis.
Development Of A Photovoltaic System Load Regulator Applying Virtual Instrumentation. (2008)

In this work, the procedure used to develop a virtual load regulator for autonomous photovoltaic systems is described. The regulator includes data acquisition and control, real time measuring of batteries voltage, and event tracking that records data items such as hour,day, month, year, kind of event and voltage magnitude in an Excel ® file. This load regulator was implemented applying virtual instrumentation through the LabVIEW® graphic programming software and a highspeed sampling rate and USB-enabled data acquisition device by National Instruments(c). Tests indicate that the virtual load regulator operation on a autonomous photovoltaic system meets the operating parameters established for these kind of devices, achieving optimal information processing, as well as having advantages and innovations compared to conventional charge controllers.
The relationship between follicular fluid aspirate volume and oocyte maturity in in-vitro fertilization cycles (1998)

As a consequence of multiple follicular growth during ovarian stimulation for in-vitro fertilization (IVF), follicles of varying sizes often yield oocytes that vary in maturity and morphology of the oocyte-cumulus-corona complex. The objective of this prospective study was to explore the relationship between follicular fluid aspirate volume and the oocyte's developmental potential in an IVF treatment cycle. In total 9933 follicles were studied from 400 patients who underwent 535 consecutive IVF treatment cycles at St James's University Hospital, Leeds, UK, between February 1995 and February 1996. The volume of each individual follicle aspirated was recorded and related to the probability of obtaining an oocyte, its fertilizing capacity, the cleavage rate and the quality of embryos derived. We found no statistically significant difference in oocyte recovery rates between follicles with an aspirate volume < or = 1 ml and follicles with a volume > 1 ml. Although oocytes obtained from follicles with an aspirate volume > or = 1 ml showed a significantly lower fertilization rate, they went on to cleave at the same rate as oocytes obtained from larger follicles and resulted in embryos of comparable quality. Furthermore, there was no statistically significant difference in the implantation, clinical pregnancy or live birth rates per cycle between embryos derived from follicles with an aspirate volume < or = 1 ml and those derived from follicles with an aspirate volume > 1 ml. We conclude that follicular size and the oocyte's developmental potential in the stimulated ovary are not closely related and can be independent. This is in contrast to the Graafian follicle and the pre-ovulatory oocyte in the natural cycle.
Exocellular Succinoglucan Production by Agrobacterium radiobacter NCIB 11883 (1987)

SUMMARY: The efficiency of growth and exopolysacharide production by Agrobacterium radiobacter NCIB 11883 was examined in both carbon- and nitrogen-limited chemostat cultures. Under carbon limitation this organism exhibited two distinct Y maxO2 values, one below D = 0·15 h-1 (40 g mol-1) and the other above this dilution rate (84 g mol-1). Under nitrogen limitation optimum exopolysaccharide production occurred at low dilution rates and under these conditions accounted for virtually all the product carbon excreted. The maximum observed yield of exopolysaccharide was 3·5 g (g O2)-1 and 0·65 g (g glucose)-1. These observed yields when corrected for the cellular requirement for glucose and oxygen gave values very similar to the theoretical value if the ATP/O quotient of carbon-limited cultures grown at corresponding dilution rates was used. Thus, the efficiency of growth of both carbon- and nitrogen-limited cultures was similar once an allowance for exopolysaccharide production was made. Under conditions optimum for polysaccharide production virtually all the respiratory activity occurring over and above that required for growth was utilized in polysaccharide production. Exopolysaccharide production is a major event in energetic terms and the rate of ATP utilization for its synthesis can be equivalent to 90% of that required for cell production. Nevertheless, because of the relationship between the structure of the polysaccharide and the ATP/O quotient extant in A. radiobacter succinoglucan production supplies up to approximately 56% of its own ATP demand during the synthesis of the acid moieties that comprise this polymer.
Photoaffinity labeling of the V1 vasopressin receptor in plasma membranes from rat liver. (1985)

Photoaffinity labeling experiments were performed with membranes from rat liver containing V1 vasopressin receptors. Photoreactive analogues of [1-beta-mercaptopropionic acid]vasopressin [( Mpa1], vasopressin, or deamino-vasopressin) retaining a high binding affinity (apparent dissociation constants: 5 X 10(-9) M-3 X 10(-8) M) and agonistic properties were used. The tritium-labeled analogue [Mpa1,Lys(N epsilon-4-azidobenzoyl)8]vasopressin preferentially and specifically labels a 30-kDa polypeptide and with lower efficiency a 38-kDa polypeptide. The analogue [Mpa1,Dab4(N gamma-(N-4-azido-2-nitrophenyl-beta-Ala4]arginine-vasopressin specifically labels the 38-kDa polypeptide. The labeling of these two membrane proteins is completely suppressed by an excess of arginine-vasopressin; bradykinin or angiotensin II do not inhibit the incorporation of the reactive vasopressin analogues into these proteins. The results suggest that the rat hepatic V1 receptor exists in the plasma membrane in an oligomeric form composed of two subunits with a molecular mass of 30 and 38 kDa.
107-gb/s optical signal generation using electronic time-division multiplexing (2006)

This paper reports the first optical transmitter implementations operating at a serial bit rate of 107 Gb/s using solely electronic time-division multiplexing. Two methods to overcome modulator bandwidth limitations are proposed and demonstrated: low-bandwidth optical duobinary modulation and integrated optical equalization. Both transmitters are characterized in terms of bit error ratio and chromatic dispersion tolerance
The denatured state (the other half of the folding equation) and its role in protein stability (1996)

Experimental studies of the physical interactions that stabilize protein structure are complicated by the fact that proteins do not unfold to a simple reference state. When their folded structure breaks down, protein chains do not become random coils. Instead, they enter a poorly understood ensemble of partially folded states known collectively as the denatured state. Although it has long been held that agents that promote protein unfolding act specifically on the denatured state, the idea that mutations can exert their destabilizing (or in some cases, stabilizing) effects directly on this state is not widely accepted. A large body of thermodynamic data on mutant proteins plus a limited amount of structural information describing mutational effects on denatured states indicate that 1) the denatured state plays a central role in all aspects of protein stability, including mutant effects, and 2) a quantitative understanding of how amino acid sequence encodes protein structure will probably depend on a more complete picture of this complex, difficult-to-study state.
Silica Nanoparticle Crystals and Ordered Coatings Using Lys-Sil and a Novel Coating Device (2007)

Silica nanoparticles with a narrow particle size distribution and controlled diameters of 10-20 nm are synthesized via hydrolysis and hydrothermal aging of tetraethylorthosilicate in an aqueous L-lysine solution. Cryo-transmission electron microscopy (cryo-TEM) reveals that the silica nanoparticles assemble to form close-packed nanoparticle crystals over short length scales on carbon-coated grids. Evaporative drying of the same sols results in nanoparticle stability and remarkable long-range facile ordering of the silica nanoparticles over scales greater than 10 microm. Whereas small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) discount the possibility of a core (silica)-shell (lysine) structure, the possibility remains for lysine occlusion within the silica nanoparticles and concomitant hydrogen bonding effects driving self-assembly. Facile ordering of the silica nanoparticles into multilayer and monolayer coatings over square-centimeter areas by evaporation-induced self-assembly is demonstrated using a novel dip-coating device.
[Changes in the level of interleukin-1 beta and interleukin-6 after implantation of selected medical materials. Introductory report]. (1998)

Evaluation of biomaterials with the help of routine methods not always allow full and explicit stating of their toxicity. That is why we still seek new methods of evaluation of biocompatibility on the cellular level. Usage of changes in activity of interleukin after biomaterials implantation creates such a possibility. The aim of this work as use of changes in activity of cytokines IL-1 beta and cytokines IL-6 for evaluation of biocompatibility of chosen medical materials. The tests were made on mice to whom polyester and aramid fibres as well as discs of rubber drains were implanted into the peritoneal cavity. Evaluation of the changes of the level of interleukin-1 beta and interleukin-6 was made in the fluid from the peritoneal cavity 3, 7, 14 and 21 days after implantation. Introductory tests of changes in the level of IL-1 beta and IL-6 after implantation of biomaterials with different degree of biocompatibility allow to assume that testing their activity may be useful in evaluation of their toxic effect.
TRAF6-Dependent Act1 Phosphorylation by the IκB Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-κB Activation (2012)

Interleukin-17 (IL-17) is critically involved in the pathogenesis of various inflammatory disorders. IL-17 receptor (IL-17R)-proximal signaling complex (IL-17R-Act1-TRAF6) is essential for IL-17-mediated NF-κB activation, while IL-17-mediated mRNA stability is TRAF6 independent. Recently, inducible IκB kinase (IKKi) has been shown to phosphorylate Act1 on Ser 311 to mediate IL-17-induced mRNA stability. Here we show that TANK binding kinase 1 (TBK1), the other IKK-related kinase, directly phosphorylated Act1 on three other Ser sites to suppress IL-17R-mediated NF-κB activation. IL-17 stimulation activated TBK1 and induced its association with Act1. IKKi also phosphorylated Act1 on the three serine sites and played a redundant role with TBK1 in suppressing IL-17-induced NF-κB activation. Act1 phosphorylation on the three sites inhibited its association with TRAF6 and consequently NF-κB activation in IL-17R signaling. Interestingly, TRAF6, but not TRAF3, which is the upstream adaptor of the IKK-related kinases in antiviral signaling, was critical for IL-17-induced Act1 phosphorylation. TRAF6 was essential for IL-17-induced TBK1 activation, its association with Act1, and consequent Act1 phosphorylation. Our findings define a new role for the IKK-related kinases in suppressing IL-17-mediated NF-κB activation through TRAF6-dependent Act1 phosphorylation.