gebhart/patrepeval huggingface dataset:
Optimization of three morphologic algorithms for arrhythmia discrimination in implantable cardioverter defibrillators (2005)

Discrimination between ventricular tachycardia (VT) and supraventricular tachycardia (SVT) in implantable cardioverter defibrillators (ICDs) is still an unsolved task due to the low specificity of traditional techniques based in rate, stability and onset. Several morphological published algorithms enhance VT vs. SVT discrimination by increasing algorithm complexity. Three morphological published algorithms with increasing complexity have been selected: time domain (complex peak area comparison), simplified wavelet and frequency domain (Fourier complex power spectra analysis and neural network) algorithms. All them have been reconstructed from published information and programmed in MATLAB. The algorithms has been optimized in order to obtain an improved classification and to work in a 16-bit microcontroller platform (Texas Instruments MSP430 microcontroller). A final test of the optimized algorithms has been accomplished using a classified unipolar and bipolar electrogram (EGM) database. The configurable parameters of the algorithms have been adjusted in order to maximize sensitivity (SE), specificity (SP) and accuracy (AC)
Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. (1995)

The murine Ca(2+)-stimulated adenylyl cyclase (type I) (EC 4.6.1.1), which is expressed predominantly in brain, was inactivated by targeted mutagenesis. Ca(2+)-stimulated adenylyl cyclase activity was reduced 40-60% in the hippocampus, neocortex, and cerebellum. Long-term potentiation in the CA1 region of the hippocampus from mutants was perturbed relative to controls. Both the initial slope and maximum extent of changes in synaptic response were reduced. Although mutant mice learned to find a hidden platform in the Morris water task normally, they did not display a preference for the region where the platform had been when it was removed. These results indicate that disruption of the gene for the type I adenylyl cyclase produces changes in behavior and that the cAMP signal transduction pathway may play an important role in synaptic plasticity.
Abstract :Fluid Detection and Porosity Determination Using Acoustic Logs in the Wilmington Field, CA (1997)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Morton integrals for high speed geometry simplification (2015)

Real time geometry processing has progressively reached a performance level that makes a number of signal-inspired primitives practical for on-line applications scenarios. This often comes through the joint design of operators, data structure and even dedicated hardware. Among the major classes of geometric operators, filtering and super-sampling (via tessellation) have been successfully expressed under high-performance constraints. The subsampling operator i.e., adaptive simplification, remains however a challenging case for non-trivial input models. In this paper, we build a fast geometry simplification algorithm over a new concept: Morton Integrals. By summing up quadric error metric matrices along Morton-ordered surface samples, we can extract concurrently the nodes of an adaptive cut in the so-defined implicit hierarchy, and optimize all simplified vertices in parallel. This approach is inspired by integral images and exploits recent advances in high performance spatial hierarchy construction and traversal. As a result, our GPU implementation can downsample a mesh made of several millions of polygons at interactive rates, while providing better quality than uniform simplification and preserving important salient features. We present results for surface meshes, polygon soups and point clouds, and discuss variations of our approach to account for per-sample attributes and alternatives error metrics.
Real‐World Data on the Lifespan of Implantable Cardioverter‐Defibrillators Depending on Manufacturers and the Amount of Ventricular Pacing (2012)

Real‐World Data on the Lifespan of ICDs Introduction: Implantable cardioverter‐defibrillator (ICD) longevity is crucial for both patients and public health systems because it determines the number of surgical ICD replacements, which can generally be considered an additional risk factor for complications, and the cost‐effectiveness of ICD therapy. Our objective was to obtain insight into the “real‐world” longevities of implantable cardioverter‐defibrillators, which quite often differ from those stated in the manufacturers’ declarations. Methods and Results: On the basis of a prospective database, we analyzed all ICD implantations performed in our hospital from June 1988 to June 2009. We studied 980 patients (follow‐up 58 ± 51 months) with 1,502 ICDs and all respective data until August 2010. We compared the percentage of still operating ICDs at different points in time in relation to manufacturers, types of device (single chamber 623, dual chamber 588, cardiac resynchronization therapy ICDs [CRT‐D] 291), and amount of right ventricular pacing (VP). We found distinct differences between the mean lifespans of ICDs of different manufacturers (Biotronik 4.3 years, Sorin 4.5 years, Guidant/Boston Scientific 4.7 years, St. Jude Medical 5 years, Medtronic 5.8 years). CRT‐D devices (hazard ratio [HR] 1.778, P = 0.0005) were associated with an elevated annual relative risk for device replacement while a decrease in the proportion of VP (HR 0.934 for each 10% decrease in VP, P < 0.0001) and Medtronic ICDs were associated with a reduced risk of device replacement (HR 0.544, P < 0.0001). Conclusion: CRT‐Ds and an elevated percentage of VP are associated with a significantly elevated risk for device replacement, while Medtronic ICDs showed the longest lifespans. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1336‐1342, December 2012)
The linear pseudospark: a high current pseudospark switch (2002)

High power switches are important components in virtually all pulsed power systems. Pseudosparks have exhibited most of the desirable properties: high repetition rate, long life, a high voltage standoff, and impressive rates of current rise. Pseudospark switches, however, are limited in their high current capability. A novel pseudospark device, called the linear pseudospark, is being developed as a high performance switch. The research is concentrating on high current and multiple series gap operation.
Assessment and characterization of in situ rotator cuff biomechanics (2013)

Rotator cuff disease is a degenerative disorder that is a common, costly, and often debilitating, ranging in severity from partial thickness tear, which may cause pain, to total rupture, leading to loss in function. Currently, clinical diagnosis and determination of disease extent relies primarily on subjective assessment of pain, range of motion, and possibly X-ray or ultrasound images. The final treatment plan however is at the discretion of the clinician, who often bases their decision on personal experiences, and not quantitative standards. The use of ultrasound for the assessment of tissue biomechanics is established, such as in ultrasound elastography, where soft tissue biomechanics are measured. Few studies have investigated the use of ultrasound elastography in the characterization of musculoskeletal biomechanics. To assess tissue biomechanics we have developed a device, which measures the force applied to the underlying musculotendentious tissue while simultaneously obtaining the related ultrasound images. In this work, the musculotendinous region of the infraspinatus of twenty asymptomatic male organized baseball players was examined to access the variability in tissue properties within a single patient and across a normal population. Elastic moduli at percent strains less than 15 were significantly different than those above 15 percent strain within the normal population. No significant difference in tissue properties was demonstrated within a single patient. This analysis demonstrated elastic moduli are variable across individuals and incidence. Therefore threshold elastic moduli will likely be a function of variation in local-tissue moduli as opposed to a specific global value.
Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment (2010)

Leptomeningeal amyloidosis associated with mutations in transthyretin (TTR) is a rare but fatal form of amyloidosis. Dementia and intracerebral haemorrhage are prominent features of this disease for which no specific therapy is known. In previous studies, we have shown that antisense oligonucleotides (ASOs) specific for human TTR could inhibit hepatic synthesis of TTR in mice transgenic for a human amyloid-associated TTR and may offer a medical means of treating systemic TTR amyloidosis. Parenteral administration of TTR-specific ASO, however, had no effect on the expression of TTR by the choroid plexus, which is believed to be the source of the amyloid protein in patients who have leptomeningeal amyloidosis. In the present study, mice transgenic for the human TTR amyloid-associated mutation Ile84Ser were treated by administration of TTR-specific ASO (50 microg or 75 microg per day) via an osmotic pump into the cerebral ventricular system over a 4-week period. Intraventricular administration of TTR-specific ASO significantly reduced choroid human TTR mRNA levels, and these findings correlated with decreased TTR in choroid plexus epithelial cells as demonstrated by immunohistochemistry. Suppression of choroid TTR expression by intraventricular administered ASO may offer a medical means of treating leptomeningeal amyloidosis.
Quantum adiabatic Markovian master equations (2012)

We develop from first principles Markovian master equations suited for studying the time evolution of a system evolving adiabatically while coupled weakly to a thermal bath. We derive two sets of equations in the adiabatic limit, one using the rotating wave (secular) approximation that results in a master equation in Lindblad form, the other without the rotating wave approximation but not in Lindblad form. The two equations make markedly different predictions depending on whether or not the Lamb shift is included. Our analysis keeps track of the various time- and energy-scales associated with the various approximations we make, and thus allows for a systematic inclusion of higher order corrections, in particular beyond the adiabatic limit. We use our formalism to study the evolution of an Ising spin chain in a transverse field and coupled to a thermal bosonic bath, for which we identify four distinct evolution phases. While we do not expect this to be a generic feature, in one of these phases dissipation acts to increase the fidelity of the system state relative to the adiabatic ground state.
Ueber <i>m</i>‐Dinitroazoxybenzol und <i>o</i>‐Azoxytoluol (1885)

Gelegentlich unserer Arbeiten iiber einige aromatische Azoxyund Azoverbindungenl) sahen wir uns veranlasst, die Angaben uber die Einwirkung alkoholischer Laugen auf Dinitrokorper von neuem zu priifen, ferner haben wir zum Vergleich mit p-Nitrotoluol nun auch 0 -Nitrotoluol mit methylillkoholischem Natron behandelt.Die bisher gewonnenen Resultate theilen wir im Folgenden
Use of an Antibacterial Envelope is Associated with Reduced Cardiac Implantable Electronic Device Infections in High‐Risk Patients (2012)

In patients prospectively identified at high risk for CIED infection, use of a commercially available antibacterial envelope was associated with a marked reduction in CIED infections when compared to a matched control cohort.
Flavor release in the mouth (1991)

Abstract The flavor perception we derive from eating a food product is determined by the nature and quantity of the flavor components, the availability of these components to the sensory system as a function of time, and the mechanisms and strategies of perception and scaling which determine the flavor quality and intensity over time as recorded by a panelist. An overview is given of the current state of knowledge in these fields as relevant to the understanding of flavor release. Special attention is given to the breakdown of the food matrix through mastication and the convective transport of the released volatiles through the upper airways to the olfactory epithelium. The effects of ingredients and the influence of the structure of food on the flavor release are also discussed. The overview is based on literature data and on results of work carried out at Unilever Research Laboratorium Vlaardingen which have not been published previously.
Nanoimprinted Organic Semiconductor Laser Pumped by a Light‐Emitting Diode (2013)

An organic semiconductor laser, simply fabricated by UV-nanoimprint lithography (UV-NIL), that is pumped with a pulsed InGaN LED is demonstrated. Molecular weight optimization of the polymer gain medium on a nanoimprinted polymer distributed feedback resonator enables the lowest reported UV-NIL laser threshold density of 770 W cm(-2) , establishing the potential for scalable organic laser fabrication compatible with mass-produced LEDs.
The College Role in Diminishing the Digital Divide Gender Gap: Assessment of Male vs. Female Computer Access and Use (2009)

This research was conducted to produce a Communication Area Network (CAN) system that can effectively send messages using an Arduino with a CAN shield and to determine characteristic robustness. CAN systems are the most prominent form of communication between microcontrollers and devices primarily within vehicles. The CAN system itself was analyzed to determine the system’s robustness and weaknesses, along with proving that a twisted-paired wire is much more effective than a non-twisted pair. A relay was used to control the CAN messages to determine CAN practical usability. An Electro-magnetic Field radiation meter was used to determine the ambient electromagnetic field intensity at which the signal of both the twisted paired wire and the non-twisted paired wire distorted.
Superior Solubility of Polysaccharides in Low Viscosity, Polar, and Halogen-Free 1,3-Dialkylimidazolium Formates (2006)

We successfully prepared low viscosity, polar, and halogen-free ionic liquids as potential solvents for a wide range of polysaccharides. A series of 1,3-dialkylimidazolium formates were produced as liquids having strong hydrogen bond acceptability. These formates had significantly lower viscosity than previously reported polar ionic liquids, in particular 1-allyl-3-methylimidazolium formate (viscosity 66cP at 25 degrees C) and 1-allyl-3-ethylimidazolium formate (67cP at 25 degrees C). Because of their strong hydrogen bond ability, various polysaccharides including amylose and (scarcely soluble) cellulose were dissolved in high concentrations under mild condition.
Synthesis of optically pure 3-(1n.pi.*)-(1S,6R)-bicyclo[4.4.0]decane-3,8-dione, a molecule which is chiral in the excited state only (1994)

Low-temp. photooxygenation of (1S,6R)-3-((E,Z)-methoxymethylene)bicyclo[4.4.0]decan-8-one, prepd. in 10 steps from 2,6-dimethoxynaphthalene, yields a mixt. of four isomeric 1,2-dioxetanes I with ee > 98%. Upon thermal decompn., these 1,2-dioxetanes are all precursors for 3-(1np*)-(1S,6R)-bicyclo[4.4.0]decane-3,8-dione (1*), an optically active diketone in its locally excited 1np* state. The optical activity of this mol. is evidenced by the nonvanishing circular polarization in the chemiluminescence of I. The degree of polarization (ge) at 420 nm equals -(1.5 +- 0.3) * 10-3, a value which is similar to that of the regular fluorescence of optically active (1S,6R,8S)-8-hydroxybicyclo[4.4.0]decan-3-one. This similarity implies the absence of substantial racemization in the excited state, whence one concludes that the rate const. for intramol. 1np* energy transfer in 1* is ?109 s-1. The chiroptical results show that localization of excitation energy at the carbonyl at the 3-position of 1* can be achieved by the synthetic route applied, yielding enantiomerically pure 1*, an optically active mol. whose chirality is due solely to the presence of localized electronic excitation energy. [on SciFinder (R)]
An INS Monitor to Detect GNSS Spoofers Capable of Tracking Vehicle Position (2017)

In this paper, we describe and evaluate a new monitor that uses inertial navigation system (INS) measurements to detect spoofing attacks on global navigation satellite system (GNSS) receivers. Spoofing detection is accomplished by monitoring the Kalman filter innovations in a tightly coupled INS/GNSS mechanization. Monitor performance is evaluated against worst case spoofing attacks, including spoofers capable of tracking vehicle position. There are two main contributions of this paper. The first is a mathematical framework to quantify postmonitor spoofing integrity risk. The second is an analytical expression of the worst case sequence of spoofed GNSS signals. We then apply these to an example spoofing attack on a Boeing 747 on final approach. The results show that GNSS spoofing is easily detected, with high integrity, unless the spoofer's position-tracking devices have unrealistic, near-perfect accuracy, and no delays.
Photoinduced Electron Transfer in Binary Blends of Conjugated Polymers (1996)

Photoexcitation of blends of two different π-conjugated polymers is shown to result in excited state intermolecular electron transfer between the two polymers. Such a novel feature of blends makes them supramolecular materials that may find applications in electronics, optoelectronics, and photonics.
Combined line-of-sight inertial stabilization and visual tracking: application to an airborne camera platform (2009)

The paper describes a novel pointing&tracking feedback algorithm for an inertially stabilized double gimbal airborne camera system equipped with a computer vision system. The key idea is to enhance the intuitive decoupled controller structure its optical axis. The resulting controller can also compensate for the apparent translation between the camera and the observed object, but then the velocity of this mutual translational motion must be measured or estimated. The proposed algorithm turns out to be more insensitive to longer sampling periods of the computer vision system.
Amino Acids and Peptides; 55<sup>1</sup>. Synthesis of Biologically Active Cyclopeptides; 7<sup>1</sup>. Total Synthesis of Chlamydocin (1986)

Methods for the synthesis of cyclopeptides containing non-essential amino acids are described. The total synthesis of the highly cancerostatic Chiamydocin is published.
Versatile, portable, and efficient OS profiling via latency analysis (2005)

Operating systems are complex and their behavior depends on many factors. Source code, if available, does not directly help understand the OS's behavior, as the behavior depends on actual workloads and external inputs. Runtime profiling is a key technique for understanding the behavior and mutual-influence of modern OS components. Such profiling is useful to prove new concepts, debug problems, and optimize the performance of existing OSs. Unfortunately, existing profiling methods lack in important areas: they do not provide much of the necessary information about the OS's behavior; they require OS modification and therefore are not portable; or they exact high overheads thus perturbing the profiled OS.
Improved techniques for result caching in web search engines (2009)

Query processing is a major cost factor in operating large web search engines. In this paper, we study query result caching, one of the main techniques used to optimize query processing performance. Our first contribution is a study of result caching as a weighted caching problem. Most previous work has focused on optimizing cache hit ratios, but given that processing costs of queries can vary very significantly we argue that total cost savings also need to be considered. We describe and evaluate several algorithms for weighted result caching, and study the impact of Zipf-based query distributions on result caching. Our second and main contribution is a new set of feature-based cache eviction policies that achieve significant improvements over all previous methods, substantially narrowing the existing performance gap to the theoretically optimal (clairvoyant) method. Finally, using the same approach, we also obtain performance gains for the related problem of inverted list caching.
Enteral and parenteral anti-endotoxin treatment in experimental colitis. (1994)

Systemic endotoxemia has been described in ulcerative colitis and Crohn's disease and shown to correlate positively with disease activity and the extent of intestinal ulceration. This study evaluated the efficacy of antibiotic and anti-endotoxic treatment in reducing systemic endotoxemia in a hapten-induced rat model of colitis. Enteral administration of paromomycin was associated with a significant reduction in systemic endotoxin concentrations (7.4 +/- 1.2 pg/ml) when compared with controls (39.8 +/- 12.6 pg/ml; p = 0.032). Intravenous injection of taurolidine was also found to significantly reduce systemic endotoxemia (3.1 +/- 1.3 pg/ml) in comparison with controls receiving saline injection (17.5 +/- 4.2 pg/ml; p = 0.008). Enteral neomycin, parenteral polymyxin or metronidazole and cefuroxime were ineffective anti-endotoxin treatments in this model. Enteral paromomycin or parenteral tauro-lidine therapy are potential methods of preventing and treating systemic endotoxemia in patients with inflammatory bowel disease.
Frequency domain blind source separation using small and large spacing sensor pairs (2004)

This work presents a method for solving the permutation problem of frequency domain blind source separation (BSS) when the number of source signals is large, and the potential source locations are omnidirectional. We propose a combination of small and large spacing sensor pairs with various axis directions in order to obtain proper geometrical information for solving the permutation problem. Experimental results show that the proposed method can separate a mixture of speech signals that came from various directions, even when two of them come from the same direction.
Intergenerational transmission of internalising and externalising behaviours across three generations: Gender‐specific pathways (2009)

The findings shed important light on potential gender-specific mechanisms of intergenerational transmission of internalising and externalising behaviour.
Alternative Compliant Interconnects: Thermo-Mechanical Reliability, Design and Testing (2001)

Abstract Two types of novel compliant interconnects are being proposed in this paper. The advantages of these two types of compliant interconnects are: accommodation of the mismatch due to different thermal expansions in electronic packages, integration with wafer-level fabrication process, low cost, fine pitch and high I/O density. The first type is a highly-compliant cantilevered spring interconnect for the next generation packaging and probing technology. To understand the reliability of the package with this novel compliant spring interconnect structure and the typical behavior of sliding contact, test vehicles with different orientations of the cantilevered springs (21 μm pitch) have been fabricated, assembled and subjected to thermal cycling test. In-situ resistance and temperature measurements have been conducted. The second type is a compliant free-standing interconnect, One-Turn Helix (OTH) structure. This structure is built as an one-turn strip helix in order to get good compliance in space. It can be fabricated through conventional photolithography-based IC fabrication process. Optimal design parameters have been identified for this structure taking into consideration the thermo-mechanical and electrical behavior of this unique structure.