gebhart/patrepeval huggingface dataset:
Evaluating Color Descriptors for Object and Scene Recognition (2009)

Image category recognition is important to access visual information on the level of objects and scene types. So far, intensity-based descriptors have been widely used for feature extraction at salient points. To increase illumination invariance and discriminative power, color descriptors have been proposed. Because many different descriptors exist, a structured overview is required of color invariant descriptors in the context of image category recognition. Therefore, this paper studies the invariance properties and the distinctiveness of color descriptors (software to compute the color descriptors from this paper is available from http://www.colordescriptors.com) in a structured way. The analytical invariance properties of color descriptors are explored, using a taxonomy based on invariance properties with respect to photometric transformations, and tested experimentally using a data set with known illumination conditions. In addition, the distinctiveness of color descriptors is assessed experimentally using two benchmarks, one from the image domain and one from the video domain. From the theoretical and experimental results, it can be derived that invariance to light intensity changes and light color changes affects category recognition. The results further reveal that, for light intensity shifts, the usefulness of invariance is category-specific. Overall, when choosing a single descriptor and no prior knowledge about the data set and object and scene categories is available, the OpponentSIFT is recommended. Furthermore, a combined set of color descriptors outperforms intensity-based SIFT and improves category recognition by 8 percent on the PASCAL VOC 2007 and by 7 percent on the Mediamill Challenge.
Approaching P2P communication in a vehicular ad hoc network (2009)

This paper introduces P2P communication across a VANET and seeks to establish under what conditions (mobility, network size, wireless channel) data streaming is feasible. Routing of streamed services over multiple hops and multiple paths may result in significant packet losses, resulting in unacceptable quality of service. This paper examines the impact of differing traffic densities and different road layouts upon a P2P overlay network. The work modeled the emerging IEEE 802.11p for vehicular networks. It is shown that the mobility pattern of the vehicles involved needs to be closely modeled to determine signal reception patterns, as does the wireless channel environment, to avoid over optimistic assessment of communication within a VANET.
The no-reflow phenomenon: epidemiology, pathophysiology, and therapeutic approach. (2005)

Over the past 20 years, advances in the management of ST segment elevation myocardial infarction have focused on the rapid achievement of patency in the infarct-related artery. The limitation of this therapeutic strategy has been exposed with the development of diagnostic techniques to assess coronary microcirculation, including myocardial contrast echo, magnetic resonance imaging, myocardial perfusion grading, and the coronary flow wire. These methods have expanded our ability to understand and recognize the no-reflow phenomenon, which describes the absence of tissue perfusion despite epicardial coronary artery patency and flow. Although the mechanisms responsible for the development of no reflow are not fully understood, the end result is microvascular damage produced by microvascular obstruction or reperfusion injury. Ideally, early recognition of the no-reflow phenomenon should provide an opportunity for therapeutic intervention designed to augment tissue perfusion and maintain the viability of myocardium at risk. A number of pharmacologic agents are being used in conjunction with percutaneous transluminal coronary angioplasty in an attempt to improve microvascular perfusion. These include IIb/IIIa receptor antagonists, adenosine, verapamil, and the experimental agent nicorandil. In the new millennium, the emphasis of reperfusion therapy is being shifted downstream from its exclusive focus on the epicardial artery to assuring normal blood flow at the tissue level. This article will review the epidemiology, pathophysiology, and therapeutic approach to this vexing clinical problem.
A ubiquitous mobile communication architecture for next-generation heterogeneous wireless systems (2005)

Rapid progress in research and development of wireless networking and communication technologies have created different types of wireless systems (e.g., Bluetooth, IEEE 802.11, UMTS, and satellite networks). These systems are envisioned to coordinate with each other to provide ubiquitous high-data-rate services to mobile users. In this article, the architecture for ubiquitous mobile communications (AMC) is introduced that integrates these heterogeneous wireless systems. AMC eliminates the need for direct service level agreements among service providers by using a third party, a network interoperating agent. Instead of deploying a totally new infrastructure, AMC extends the existing infrastructure to integrate heterogeneous wireless systems. It uses IP as the interconnection protocol. By using IP as the gluing protocol, transparency to the heterogeneities of the individual systems is achieved in AMC. Third-party-based authentication and billing algorithms are designed for AMC. New mobility management protocols are also developed to support seamless roaming between different wireless systems.
The endocrine polypeptide cells of the human stomach, duodenum, and jejunum (1970)

Thirty specimens of stomach, duodenum, and jejunum, removed at operation, were examined by optical microscopical, cytochemical, and electron microscopical techniques. The overall distribution of four types of endocrine polypeptide cell in the stomach, and three in the intestine, was determined. The seven cell types are described by names and letters belonging to a scheme for nomenclature agreed upon at the 1969 Wiesbaden conference on gastrointestinal hormones. The gastrin-secreting G cell was the only cell for which firm identification with a known hormone was possible. Although there was wide variation in the distribution of the various cells, from one case to another, striking differences were nevertheless observable, with respect to the G cell, between antra from carcinoma and from ulcer cases.
Design of a Wearable 12-Lead Noncontact Electrocardiogram Monitoring System (2019)

A standard 12-lead electrocardiogram (ECG) is an important tool in the diagnosis of heart diseases. Here, Ag/AgCl electrodes with conductive gels are usually used in a 12-lead ECG system to access biopotentials. However, using Ag/AgCl electrodes with conductive gels might be inconvenient in a prehospital setting. In previous studies, several dry electrodes have been developed to improve this issue. However, these dry electrodes have contact with the skin directly, and they might be still unsuitable for patients with wounds. In this study, a wearable 12-lead electrocardiogram monitoring system was proposed to improve the above issue. Here, novel noncontact electrodes were also designed to access biopotentials without contact with the skin directly. Moreover, by using the mechanical design, this system allows the user to easily wear and take off the device and to adjust the locations of the noncontact electrodes. The experimental results showed that the proposed system could exactly provide a good ECG signal quality even while walking and could detect the ECG features of the patients with myocardial ischemia, installation pacemaker, and ventricular premature contraction.
The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches (2016)

Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years, screening for p53 activators and a better understanding of the molecular mechanisms of oncogenic perturbations of p53 function have opened up a host of novel avenues for therapeutic intervention in cancer: from the structure-guided design of chemical chaperones to restore the function of conformationally unstable p53 cancer mutants, to the development of potent antagonists of the negative regulators MDM2 and MDMX and other modulators of the p53 pathway for the treatment of cancers with wild-type p53. Some of these compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, personalized anticancer medicines. We trace the structural evolution of the p53 pathway, from germ-line surveillance in simple multicellular organisms to its pluripotential role in humans.
The total Walldius knee endoprosthesis in combination with retropatellar facet replacement (Polyethylene). Indication, operative procedure, and clinical results in a two year follow‐up study (1974)

Abstract Total replacement of the knee joint often remains unsatisfactory because of severe femor‐patellar osteoarthritis. Twenty‐four Walldius knee prostheses were inserted in 21 cases. Since March 1971 we have used a combination of this type of hinge prosthesis with a high‐density polyethylene retropatellar facet prosthesis developed by our group in cooperation with the Badische Anilin‐ & Soda Fabrik AG (BASF). Fourteen knees of this combined type have been implanted and resulted in considerably less complaints than the original Walldius knee. The postoperative range of motion with an average of 66° does not differ in both groups.
Electronic monitoring of treatment compliance in patching for amblyopia (1999)

We developed a coinsized occlusion dose monitor (ODM) to measure compliance with patch-wearing during the treatment of amblyopia objectively. It measures the temperature difference between the front and back of the ODM every 2-5 minutes by means of two thermistors. The data is stored in EEPROM memory and read out after recording for a week by connecting it to a PC. The ODM measures 35x23x4 mm and weighs 6 g. The back of the ODM is glued to the front of the amblyopia patch with double-sided Scotch tape. When the patch with the ODM is on the eye, the temperature at the back of the ODM is higher than at the front. Compliance is being studied in children taking part in a large amblyopia cohort study. The parents were instructed during home visits every three months to put the ODM on the patch. After a week, the ODM was collected and read out. Although the parents knew that a recording was being made, compliance was mediocre in many cases. Children were patched infrequently, for 5 minutes only, for long periods on the last days of the recording, at night, etc. Diaries detailing patch time were unreliable.
Conversion of Diarylphosphine Oxides to Phosphinous Chlorides with Phosphorus Trichloride<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of Diarylphosphine Oxides to Phosphinous Chlorides with Phosphorus Trichloride1Ronald E. Montgomery and Louis D. QuinCite this: J. Org. Chem. 1965, 30, 7, 2393–2395Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/jo01018a068https://doi.org/10.1021/jo01018a068research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evidence of two levels of control of P1 oriR and host oriC replication origins by DNA adenine methylation (1993)

A mutant mini-P1 plasmid with increased copy number can be established in Dam- strains of Escherichia coli, where mini-P1 plasmid replication is normally blocked. Comparison of this plasmid and a plasmid driven by the host oriC replication origin showed that both origins are subject to control by methylation at two different levels. First, both origins appear to be subject to negative regulation acting at the level of hemimethylation. This probably involves the sequestration of the hemimethylated DNA produced by replication, as has been previously described for oriC. Second, both origins show a positive requirement for adenine methylation for efficient function in vivo. This conclusion is supported by the behavior of the P1 origin in an improved in vitro replication system. In vitro, where sequestration of hemimethylated DNA is not expected to occur, the hemimethylated P1 origin DNA was fully functional as a template. However, the activity of fully unmethylated DNA was severely restricted in comparison with that of either of the methylated forms. This in vitro uncoupling of the two effects of origin methylation suggests that two separate mechanisms are involved.
Light scattering and viscosity study of electron‐irradiated polystyrene and polymethacrylates (1956)

Abstract The solution viscosity behavior of polymers previously irradiated by high‐energy sources is treated theoretically by a combination of existing random crosslinking and degradation theory and branched‐polymer solution viscosity theory. The derived relations are applied to data on polystyrene, polymethyl methacrylate and poly‐ tert ‐butyl methacrylate irradiated as films in air with 1000 kvp. electrons. Polystyrene films underwent gelation exhibiting an energy dissipation per crosslinked unit E c = 855 electron volts and a main‐chain scission to crosslinked unit ratio α/β = 0.35. Pregelation light‐scattering molecular weights of the irradiated polystyrene predicted an incident gelation dose (9.4 megareps) in good agreement with that (10.3 megareps) observed by gel measurements. Theory satisfactorily reproduced the solution viscosity data over a wide range of pregelation radiation doses. A combination of light‐scattering and intrinsic viscosity data proved conclusively that no appreciable crosslinking occurs during the degradation of polymethyl methacrylate under 1000 kvp. electrons. The apparent energy dissipation per main‐chain scission, E d = 58–62 e.v., determined by viscometry is therefore the true E d in this instance. Reactions leading to crosslinking in polyacrylates are either blocked or diverted by the methyl group on the polymethacrylate backbone. Poly‐ tert ‐butyl methacrylate degrades under electron bombardment with an E d = 43 e.v.
Context-Adaptive Privacy: Leveraging Context Awareness to Support Privacy Decision Making (2015)

Ubiquitous computing applications introduce multiple privacy challenges due to their sensing and actuation capabilities, which are often combined with ubiquitous interconnectivity. Because of the complexity of many ubicomp systems, users might have difficulties estimating the privacy implications of their actions and decisions. In this article, the authors discuss leveraging awareness about a user's context and respective context changes to dynamically support privacy decision making. They present an operationalization of Irwin Altman's privacy regulation theory for this purpose, describing how individual phases of the process can be supported. They also report on their experiences in developing context-adaptive privacy mechanisms for different applications and domains. This article is part of a special issue on privacy and security.
Electron beam generation by electron multiplication (1989)

We have demonstrated that intense pulsed electron beams can be created by multiplication of lower current electron streams impinging on a high electron yield target. A 17 A electron beam of 1 μs pulse width was generated from a 2.5 A beam bombarding an activated Ag-Mg target 2.5 cm in diameter.
Empirical Analysis on Financial Development, Urbanization, and Urban and Rural Resident Income in Jiangsu Province (2016)

On the basis of the time series data of Jiangsu Province in 1990-2013, this paper made an empirical analysis on the dynamic relation between financial development, urbanization, and urban and rural resident income, and income gap. Studies have shown that expansion of financial development scale and increase in financial development efficiency can promote increase in urban and rural resident income. However, due to existence of rural financial repression problem, the increase in financial efficiency widens the urban and rural income gap; the urbanization level of Jiangsu Province remains stable stage; the increase in urbanization level practically raises urban and rural resident income level. Since the traditional extensive growth mode of urbanization lacks concern for balanced urban and rural development, urbanization development widens the urban and rural income gap. In view of these, it came up with policy recommendations including deepening financial reform, expanding the scale of rural financial institutions, increasing rural financial efficiency, and attaching great importance to the quality of urbanization development.
Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver. (1981)

An antibody to the low density lipoprotein (LDL) receptor was prepared by immunization of rabbits with a partially purified receptor preparation from bovine adrenal cortex. Immunoglobulin G (IgG) isolated from the serum of immunized rabbits blocked the binding of 125I-LDL to intact bovine adrenal membranes as well as to the partially purified bovine adrenal LDL receptor. The anti-receptor IgG also blocked the binding, uptake, and degradation of 125I-LDL by monolayers of human fibroblasts and thus prevented the LDL-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase. A monovalent Fab fragment of th anti-receptor IgG retained the ability to inhibit LDL receptors of partially purified bovine adrenal cortex and monolayers of human fibroblasts. By immunofluorescence staining, the anti-receptor IgG was shown to bind to normal fibroblasts in discrete foci that were linearly arranged on the cell surface. No such foci were seen on fibroblasts from a patient with the receptor-negative form of homozygous familial hypercholesterolemia. The rabbit anti-receptor IgG also blocked the binding of 125I-LDL to membranes from dog and rat liver, but it did not prevent LDL binding to rabbit adrenal membranes or rabbit fibroblasts. The immunologic cross-reactivity of LDL receptors from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver indicates that the structure of this receptor has been widely conserved among animal species and tissues.
Glycerol Kinase, the Pacemaker for the Dissimilation of Glycerol in <i>Escherichia coli</i> (1970)

The activity of glycerol kinase is rate-limiting in the metabolism of glycerol by cells of Escherichia coli. A mutant strain producing a glycerol kinase resistant to inhibition by fructose-1,6-diphosphate grows faster than its wild-type parent on glycerol as the sole source of carbon and energy. The amount of intracellular fructose-1,6-diphosphate was determined for wild-type cells growing exponentially on glycerol. The water content of such cells was also determined, allowing calculation of the intracellular concentration of fructose-1,6-diphosphate. This value, 1.7 mm, is adequate to exert substantial inhibition on the wild-type glycerol kinase. The desensitization of glycerol kinase to feedback inhibition also enhances the power of glycerol to exert catabolite repression, both on the enzymes of the glycerol system itself and on those of the lactose system. However, desensitization of glycerol kinase alone does not eliminate the phenomenon of diauxic growth in a glucose-glycerol medium. Biphasic growth in such a medium is abolished if the altered enzyme is produced constitutively. The constitutive production of the mutant kinase at high levels, however, renders the cells vulnerable to glycerol. Thus, when the cells have been grown on a carbon source with a low power for catabolite repression, e.g., succinate, sudden exposure to glycerol leads to overconsumption of the nutrient and cell death.
Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer <i>In Vivo</i> (2012)

Cancer-associated fibroblasts (CAF) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directly to tumor growth is unclear. To study the role of CAFs in NSCLCs, a cross-species functional characterization of mouse and human lung CAFs was conducted. CAFs supported the growth of lung cancer cells in vivo by secretion of soluble factors that directly stimulate the growth of tumor cells. Gene expression analysis comparing normal mouse lung fibroblasts and mouse lung CAFs identified multiple genes that correlate with the CAF phenotype. A gene signature of secreted genes upregulated in CAFs was an independent marker of poor survival in patients with NSCLC. This secreted gene signature was upregulated in normal lung fibroblasts after long-term exposure to tumor cells, showing that lung fibroblasts are "educated" by tumor cells to acquire a CAF-like phenotype. Functional studies identified important roles for CLCF1-CNTFR and interleukin (IL)-6-IL-6R signaling in promoting growth of NSCLCs. This study identifies novel soluble factors contributing to the CAF protumorigenic phenotype in NSCLCs and suggests new avenues for the development of therapeutic strategies.
The function and mechanisms of action of LOXL2 in cancer (Review) (2015)

The lysyl oxidase (LOX) family is comprised of five members, and some members have recently emerged as important regulators of tumor progression. Among these, at present, LOX‑like (LOXL)2 is the prototypical LOX and the most comprehensively studied member. A growing body of evidence has implicated LOXL2 in the promotion of cancer cell invasion, metastasis and angiogenesis, as well as in the malignant transformation of solid tumors. Moreover, a high expression of LOXL2 is associated with a poor prognosis. These data have piqued the interest of a number of researchers and research groups, who have identified LOXL2 as a strong target candidate in the development of inhibitors for use as functional and efficacious tumor therapeutics. In the present study, we summarize the recent progress made regarding LOXL2, mainly focusing on its function and mechanisms of action in tumor progression and metastasis. In this review, we note that LOXL2 promotes tumor progression possibly by activating multiple signal pathways through a variety of mechanisms, both biochemical and biomechanical. The data presented herein may open new avenues for the therapeutic utility of LOXL2.