gebhart/patrepeval huggingface dataset:
Suppression of matrilysin inhibits colon cancer cell invasion <i>in vitro</i> (1995)

Matrilysin is a member of the matrix metalloproteinase gene family, which is believed to play an important role in tumor invasion and metastasis. We examined the effects of over- and under-expression of matrilysin on the ability of colon cancer cells to migrate across an artificial membrane in vitro. Introduction of matrilysin caused colon cancer cells to become more invasive as assessed by an in vitro invasion assay. In contrast, expression of matrilysin was down-regulated by all trans-retinoic acid or by introduction of anti-sense matrilysin in BM314 colon cancer cells. This down-regulation caused these cells to become less invasive. We demonstrated a correlation between matrilysin level and the invasive potential of human colon cancer cells, implying an important role for matrilysin in the control of tumor invasion in vitro.
438. Fluorocyclopentanes. Part III. The isomeric 1H:2H:3H-and 1H:2H:4H-heptafluorocyclopentanes and the 1H:2H:3H:4H-hexafluorocyclopentanes (1965)

J. Burdon, T. M. Hodgins, R. Stephens and J. C. Tatlow, J. Chem. Soc., 1965, 2382 DOI: 10.1039/JR9650002382
New developments in the use of fibrin sealant: a surgeon's perspective. (1997)

Fibrin sealant, a surgical tissue adhesive, has gained widespread use for its ability to achieve three major clinical goals: reducing hemorrhage, increasing tissue adherence, and allowing drug delivery. The object of this state-of-the-art review is to clarify the most recent developments in this field from a surgical perspective. The areas of greatest interest and progress relating to surgical uses for fibrin sealant--specifically, new methods of sealant production, new experimental or clinical uses, and new potential complications--are explored in this review.
SPERMATOGENESIS AND ENDOCRINE ACTIVITY IN GRAFTS OF FROZEN AND THAWED RAT TESTIS (1954)

SUMMARY Testes of prepubertal rats retain their capacity to grow and differentiate as homografts after gradual freezing to − 79° C and thawing. Spermatozoa are formed in scrotal grafts.
Controlled release of subretinal fluid. (1975)

Drainage os subretinal fluid is generally regarded as being unnecessary when local buckling procedures are carried out, particularly when the buckle is placed radially, unless the patient has chronic glaucoma or the choroidal vessels are markedly sclerosed.However, there are many cases of retinal detachment where the eye is otherwise normal and where radial procedure is the detachment operation of choice in which a limited and controlled release of subretinal fluid will help considerably in the localisation, treatment by cryotherapy and final positioning of the tear on the buckle. This paper describes the technique employed and the advantages which may be gained by using this method in cases of deep bullous detachment of the retina. The results which have been obtained in cases in which this method has been used during the last 3 years are described.
High-yield synthesis of hollow boron nitride nano-polyhedrons (2011)

Hollow boron nitride nano-polyhedrons have been successfully prepared by annealing of boron nitride nanoparticles in a nitrogen atmosphere at 1800 °C without a catalyst. In our two-step process, we demonstrated that these boron nitride nanoparticles prepared by spray-pyrolysis of borazine are key precursors to grow these architectures. The samples were carefully analyzed using electron microscopies and Energy-Dispersive X-ray spectroscopy analysis. Based on such characterization tools, the growth mechanism of these architectures has been discussed and detailed. It is noteworthy that these nanostructures are generated via a solid-state transformation in relatively high yields without a metal catalyst and might open new opportunities in exploring chemical and physical properties.
Dynamic metabolomic data analysis: a tutorial review (2009)

In metabolomics, time-resolved, dynamic or temporal data is more and more collected. The number of methods to analyze such data, however, is very limited and in most cases the dynamic nature of the data is not even taken into account. This paper reviews current methods in use for analyzing dynamic metabolomic data. Moreover, some methods from other fields of science that may be of use to analyze such dynamic metabolomics data are described in some detail. The methods are put in a general framework after providing a formal definition on what constitutes a 'dynamic' method. Some of the methods are illustrated with real-life metabolomics examples.
A Flexible Poisoning Attack Against Machine Learning (2019)

Recent years have witnessed tremendous academic efforts and industry growth in machine learning. The security of machine learning has become increasingly prominent. Poisoning attack is one of the most relevant security threats to machine learning which focuses on polluting the training data that machine learning needs during the training process. Specifically, the attacker blends crafted poisoning samples into training data in order to make the learned model beneficial to him. To the best of our knowledge, existing researches about poisoning attack focused on either integrity attack or availability attack, which did not unify these two attacks together. Aside from that, from the attacker's perspective, attacker's strategy is not flexible enough. Finally, existing proposals only concentrated on increasing the test error of the learned model but ignored the importance of the concealment of attack. To overcome these issues, we firstly present a thorough adversarial model for poisoning attack in which attacker's strategy is defined from two aspects, i.e., the effect of attack and the concealment of attack. Then we unify integrity attack and availability attack together in similar formulations. Furthermore, in order to enhance flexibility, a tradeoff parameter is inserted into attacker's objective function which means the attacker can balance the attraction of effect against the requirement of concealment. Finally, as examples, extensive experiments are conducted on linear regression and logistic regression to demonstrate the effectiveness of attack.
A Parallel Decision Tree-Based Method for User Authentication Based on Keystroke Patterns (2005)

We propose a Monte Carlo approach to attain sufficient training data, a splitting method to improve effectiveness, and a system composed of parallel decision trees (DTs) to authenticate users based on keystroke patterns. For each user, approximately 19 times as much simulated data was generated to complement the 387 vectors of raw data. The training set, including raw and simulated data, is split into four subsets. For each subset, wavelet transforms are performed to obtain a total of eight training subsets for each user. Eight DTs are thus trained using the eight subsets. A parallel DT is constructed for each user, which contains all eight DTs with a criterion for its output that it authenticates the user if at least three DTs do so; otherwise it rejects the user. Training and testing data were collected from 43 users who typed the exact same string of length 37 nine consecutive times to provide data for training purposes. The users typed the same string at various times over a period from November through December 2002 to provide test data. The average false reject rate was 9.62% and the average false accept rate was 0.88%.
School Regulation of Exotic Body Piercing (2000)

I. Introduction II. Body Piercing: The Latest Craze (and You Thought Pet Rocks Were Weird) III. First Amendment Protection of Body Piercing (or How Can You Exercise Free Speech with That Thing in Your Mouth?) … A. Student First Amendment Rights … B. Body Piercings as “Speech” IV. Fourteenth Amendment Protection of Body Piercing (or How Can You Even Mention “Rational” and “Body Piercing” in the Same Breath?) V. Crafting a Constitutionally Acceptable Regulation … A. Health and Hygiene … B. Disruption … C. Discipline VI. Conclusion
Physical Health Care Within Mental Health Services - NSW Department of Health (2009)

Physical Health Care Within Mental Health Services , This Policy Directive provides direction to NSW mental health services regarding the provision of physical health care to the consumers who use their service. It should be read in conjunction with the NSW Health Guidelines for the Physical Health Care of Mental Health Consumers - GL2009_007.
BARBITURATES (1988)

From the Department of Pharmacology, School of Medicine and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90024.
Compressibility Loss for Neural Network Weights (2019)

In this paper we apply a compressibility loss that enables learning highly compressible neural network weights. The loss was previously proposed as a measure of negated sparsity of a signal, yet in this paper we show that minimizing this loss also enforces the non-zero parts of the signal to have very low entropy, thus making the entire signal more compressible. For an optimization problem where the goal is to minimize the compressibility loss (the objective), we prove that at any critical point of the objective, the weight vector is a ternary signal and the corresponding value of the objective is the squared root of the number of non-zero elements in the signal, thus directly related to sparsity. In the experiments, we train neural networks with the compressibility loss and we show that the proposed method achieves weight sparsity and compression ratios comparable with the state-of-the-art.
Fifteen nanometer features by sidewall processing and pattern transfer (1994)

A technique which uses conformally deposited silicon oxynitride on e-beam written polymethylmethacrylate structures to define 15 nm linewidths is described. The sidewalls can be used simply to narrow the opening in resist to produce fine metal lines with a lift-off process. Freestanding nitride structures can be produced which may be used for pattern transfer in a variety of methods. We demonstrate the production of narrow slots in metal. Additional processing is able to produce narrow slots in resist that then can be used for pattern transfer. We demonstrate a pair of 15 nm metal lines separated by approximately 20 nm. This technique can be applied to the fabrication of quantum effect devices, and has the potential of being extended to well below 10 nm features. These techniques have the potential to be applied in manufacturing since sidewall processing is already used widely in commercial complementary metal–oxide semiconductor processes.
Inorganic Phosphate and Sodium Ions Are Cogerminants for Spores of <i>Clostridium perfringens</i> Type A Food Poisoning-Related Isolates (2009)

Clostridium perfringens type A isolates carrying a chromosomal copy of the enterotoxin (cpe) gene are involved in the majority of food poisoning (FP) outbreaks, while type A isolates carrying a plasmid-borne cpe gene are involved in C. perfringens-associated non-food-borne (NFB) gastrointestinal diseases. To cause diseases, C. perfringens spores must germinate and return to active growth. Previously, we showed that only spores of FP isolates were able to germinate with K(+) ions. We now found that the spores of the majority of FP isolates, but none of the NFB isolates, germinated with the cogerminants Na(+) and inorganic phosphate (NaP(i)) at a pH of approximately 6.0. Spores of gerKA-KC and gerAA mutants germinated to a lesser extent and released less dipicolinic acid (DPA) than did wild-type spores with NaP(i). Although gerKB spores germinated to a similar extent as wild-type spores with NaP(i), their rate of germination was lower. Similarly, gerO and gerO gerQ mutant spores germinated slower and released less DPA than did wild-type spores with NaP(i). In contrast, gerQ spores germinated to a slightly lesser extent than wild-type spores but released all of their DPA during NaP(i) germination. In sum, this study identified NaP(i) as a novel nutrient germinant for spores of most FP isolates and provided evidence that proteins encoded by the gerKA-KC operon, gerAA, and gerO are required for NaP(i)-induced spore germination.
Influence of Hydrogen Bonding on the Adhesive Properties of Photo-Curable Acrylics (2009)

Novel hot melt pressure sensitive adhesives (HMPSAs) were developed from acrylic terpolymers of 2-ethylhexyl acrylate (EHA), hydroxyethyl acrylate (HEA), and methyl acrylate (MA) functionalized with hydrogen bonding and photo-reactive functionalities. The hydrogen bonding and photo-reactive sites were introduced from the reaction of HEA repeat units with cyclohexyl isocyanate and cinnamoyl chloride, respectively. The functionalization reaction conditions were optimized to tailor the degree of urethane and cinnamate groups in order to examine the influence of hydrogen bonding and photo-active groups in low Tg acrylics. The synergy of hydrogen bonding and photo-reactivity resulted in higher peel values and rates of cinnamate photo-reactivity with increasing urethane concentration. The increase in cinnamate photo-reactivity with increasing urethane concentration provides evidence that hydrogen bond associations can promote cinnamate dimerization. Isothermal rheological experiments conducted at 150°C confirmed the melt stability of the cyclohexyl urethane linkage, cinnamate, and the acrylic composition indicating the potential for hot melt adhesive applications.
Multilayer filters with wide transmittance bands, II (1973)

The approximate theories of Epstein and Thelen for the design of filters with suppressed stop bands (or extended pass bands) are elaborated by exact calculations. Small discrepancies are discussed. New designs, including one with a suppressed first-order band, are presented.
Kalman Filter based Tracking for Channel Aging in Massive MIMO Systems (2018)

We consider the problem of channel aging in massive multi-user multiple-input-multiple-output (MIMO) wireless systems using the Kalman filters without knowledge of channel correlation statistics. Although Wiener filtering can be used to estimate the channel state information to construct accurate precoders and decoders, their use is limited in the case where regular adaptation to channel changes is needed. In addition, since different users exhibit different mobility conditions, use of an adaptive Kalman filter is advantageous when compared to conventional estimation approaches. We build a general model that allows a wide range of user mobilities in each cell. Simulations using the model reveal that the Kalman filter is effective in predicting channel coefficients to build an effective precoder. In addition, we perform both uplink and downlink analysis and show that with poorer channel tracking, the achievable rates in massive MIMO diminish unless more accurate channel estimates are present.
Cache contention and application performance prediction for multi-core systems (2010)

The ongoing move to chip multiprocessors (CMPs) permits greater sharing of last-level cache by processor cores but this sharing aggravates the cache contention problem, potentially undermining performance improvements. Accurately modeling the impact of inter-process cache contention on performance and power consumption is required for optimized process assignment. However, techniques based on exhaustive consideration of process-to-processor mappings and cycle-accurate simulation are inefficient or intractable for CMPs, which often permit a large number of potential assignments. This paper proposes CAMP, a fast and accurate shared cache aware performance model for multi-core processors. CAMP estimates the performance degradation due to cache contention of processes running on CMPs. It uses reuse distance histograms, cache access frequencies, and the relationship between the throughput and cache miss rate of each process to predict its effective cache size when running concurrently and sharing cache with other processes, allowing instruction throughput estimation.We also provide an automated way to obtain process-dependent characteristics, such as reuse distance histograms, without offline simulation, operating system (OS) modification, or additional hardware. We tested the accuracy of CAMP using 55 different combinations of 10 SPEC CPU2000 benchmarks on a dual-core CMP machine. The average throughput prediction error was 1.57%.
An X-Ray Crystallographic Study on the Absolute Configuration of Dihydroyashabushiketol and the Solvent-dependence of Its Optical Rotation (1983)

Abstract The absolute configuration of dihydroyashabushiketol was established to be S on the basis of the X-ray crystallographic analysis of the 4′,4″-dibromo derivative. In addition, it was found that the sense of the optical rotations of dihydroyashabushiketol and its dibromo derivative is determined by the interaction of their C-5 hydroxyl group with the solvent used for the measurements.
Consultancy srevices for project preparatory studies for package III (Phase I) - Final design report (2006)

Road improvement works for the Punjab State Road Sector Project for India are likely to have adverse social impacts. Acquisition of land, eviction of squatters and encroachers are also likely to cause social disruption and economic loss for Project Affected Persons and their families. This plan aims to minimize disturbance and loss to affected populations because of the project. In keeping with this aim, a Base Line Socio-Economic Survey was conducted to identify the affected persons due to the widening of the road, determine the effect of the project on the people and community, explore options for minimizing the adverse effects, and also to come up with a Resettlement and Rehabilitation Action Plan that will ensure restoration of livelihoods. This document provides details about the Project Affected Families and appropriate resettlement mechanisms to be used, as well as various activities during project implementation that will minimize adverse social impacts on the people and the area. Under the resettlement policy and relevant laws, there is provision to pay resettlement assistance to displaced persons including the non-title holders for loss of structures, additional assistance for those belonging to vulnerable categories and provision for negotiating compensation for land and property lost on the basis of replacement cost. Apart from this, all payments (compensation and resettlement and rehabilitation assistance) will be made to affected persons before taking over possession of such land. Transitional allowance, shifting allowance, skill up-grading/training for affected people, assistance for damage to standing crops, the choice for resettling either in the resettlement colony or self-relocation, etc., have been included to ensure restoration of livelihood within a reasonable period of time.
Identical Structural and Receptor Binding Defects in Apolipoprotein E2 in Hypo-, Normo-, and Hypercholesterolemic Dysbetalipoproteinemia (1983)

Apolipoprotein E (apoprotein E or apo-E) from type III hyperlipoproteinemic subjects with the E2/2 homozygous phenotype displays both structural and receptor binding heterogeneity. The apo-E from all subjects thus far studied, however, has been functionally defective, though to different degrees. Although nearly every type III hyperlipoproteinemic subject has the E2/2 phenotype, 95-99% of the people with this same phenotype do not display type III hyperlipoproteinemia, nor do they have elevated plasma cholesterol levels. Consequently, it became important to determine whether the apo-E2 from hypo- and normocholesterolemic individuals with the E2/2 phenotype is also functionally abnormal. To do this, apo-E2 was isolated from two hypo-, two normo- and two hypercholesterolemic homozygous E2/2 subjects. The apo-E2 was recombined with vesicles and tested for its ability to displace (125)I-low density lipoproteins (LDL) from apo-B,E (LDL) receptors on human fibroblasts. The apo-E2 from all six subjects was found to be severely defective in receptor binding (<2% of the binding activity of normal apo-E3). In all cases, the binding activity of the apo-E2 was increased 10- to 20-fold by treating the apoproteins with cysteamine, a reagent that converts cysteine residues to positively charged lysine analogues. The cysteine content of each apo-E was determined by monitoring the change in the isoelectric focusing position of the cysteamine-treated apo-E2. Using this method, it was found that the apo-E2 from each subject contained two cysteine residues per mole. A partial sequence analysis of the cysteine-containing regions of the apo-E from three of the six subjects indicated that the two cysteine residues were at residues 112 and 158 in the amino acid sequence. The cysteine at residue 158 has previously been implicated in the severe binding defect of the apo-E2 from a type III hyperlipoproteinemic subject. Since the apo-E2 of the hypo-, normo-, and hypercholesterolemic subjects in this study all displayed a severe functional abnormality, it is apparent that factors in addition to the defective receptor binding activity of the apo-E2 are necessary for the manifestation of type III hyperlipoproteinemia.
Molecular cloning of a gene encoding an ARS binding factor from the yeast Saccharomyces cerevisiae. (1990)

We report the isolation of the gene for origin binding factor 1 (OBF1) from the yeast Saccharomyces cerevisiae by screening a yeast genomic DNA library in lambda gt11 with an ARS-specific oligonucleotide probe. One recombinant encoded a fusion protein of approximately 180 kDa that bound ARS-specific oligonucleotide probes in vitro. The restriction map of this gene was determined after isolation of the complete gene by screening a yeast genomic DNA library in YEp24. Characterization of the gene for OBF1 by pulsed-field gel electrophoresis and Northern and Southern blot analyses demonstrated that (i) the gene is located in chromosome IV, (ii) the gene is a single-copy gene, (iii) the mRNA is approximately 3.8 kilobases, which could code for an approximately 130-kDa polypeptide, consistent with the reported size of OBF1. An antibody, affinity-purified using the lysogen-encoded fusion protein, specifically detected an approximately 130-kDa polypeptide in yeast extract. The isolation of the gene for OBF1 should allow further analysis of the mechanism of action of this protein in vitro and in vivo.
Phase behavior and microstructure of polyoxyethylene trisiloxane surfactants in aqueous solution (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticlePhase behavior and microstructure of polyoxyethylene trisiloxane surfactants in aqueous solutionM. He, R. M. Hill, Z. Lin, L. E. Scriven, and H. T. DavisCite this: J. Phys. Chem. 1993, 97, 34, 8820–8834Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/j100136a030https://doi.org/10.1021/j100136a030research-articleACS PublicationsRequest reuse permissionsArticle Views535Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts