gebhart/patrepeval huggingface dataset:
Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease InhibitorsHarvey I. Skulnick, Paul D. Johnson, W. Jeffrey Howe, Paul K. Tomich, Kong-Teck Chong, Keith D. Watenpaugh, Musiri N. Janakiraman, Lester A. Dolak, James P. McGrath, and Cite this: J. Med. Chem. 1995, 38, 26, 4968–4971Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/jm00026a002https://doi.org/10.1021/jm00026a002research-articleACS PublicationsRequest reuse permissionsArticle Views287Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tissue-Engineered Human Corneal Endothelial Cell Sheet Transplantation in a Rabbit Model Using Functional Biomaterials (2007)

These results indicate that using cultured HCECs and functional biomaterials, PNIPAAm and gelatin, an effective cell sheet-based therapy can be developed for the treatment of corneal endothelium deficiency.
Aerodynamic characteristics of a flexible membrane wing (1986)

The results of experimental studies of the aerodynamic characteristics of single-surfac e membrane wings constructed of inextensible flexible material are described and compared with theory. The experiments included measurement of the lift and drag characteristics of semispan wing models of three different planforms (triangular, parabolic, and elliptical). The wing surfaces were constructed of 2- and 4-mil stainless steel shim stock attached to a streamline leading-edge spar. This very thin metal membrane is flexible and adjusts its shape in response to the airflow over the wing surface. The experimental apparatus permitted variation of the camber and twist distribution of the wing. A unique method of describing the geometry of the wing is presented and used to correlate the experimental results and to compare experiment with theory. The experimental results agree well with lifting line theory below stall using the method presented for determining the geometric shape of the wing. The wing with the parabolic planform exhibited the best aerodynamic characteristics compared to the triangular and elliptical planforms. The maximum lift coefficients and lift-to-drag ratios measured are comparable to conventional rigid wings. Various dynamic phenomena encountered during the experiments are described.
The bacterial protein Hfq: much more than a mere RNA-binding factor (2012)

Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally identified in Escherichia coli as a host factor required for replication of the Qβ RNA phage. In this review, we present a comprehensive summary of 40 years of investigation to learn that Hfq is an influential, though not essential, global regulator of gene expression in bacteria and that this feature is undoubtedly linked to Hfq's RNA-binding properties. This protein intervenes in different RNA transactions, notably the promotion of antisense interactions between messenger RNAs and small regulatory RNAs. Yet, several aspects of its molecular mechanism remain not understood. In addition, mechanistic studies have been exclusively carried out in enterobacterial models, highlighting the need to expand the research on Hfq function to other taxons. Upon reviewing the genetic, structural, biochemical, and biological aspects of this extraordinary protein, we discuss recent findings on interactions with macromolecules other than RNA suggesting a broader participation of Hfq in major steps in the flow of genetic information. We show that, although significant progress has been achieved to elucidate Hfq role at the molecular level, many open questions remain.
Performance analysis of variable rate: symbol-by-symbol adaptive bit interleaved coded modulation for Rayleigh fading channels (2002)

A challenging problem for a high-speed data service over wireless is to protect data over the error-prone fading channel in an effective way (high-bandwidth efficiency). We propose a bandwidth-efficient error correction scheme, namely variable rate adaptive bit interleaved coded modulation (ABICM), for the wireless mobile channel. The code rate and modulation level are varied according to the current channel state to exploit the time-varying nature of the wireless channel. Design challenges to achieve symbol-by-symbol adaptation are addressed. In particular, we address the criteria for choosing the family of component codes for the ABICM system. We propose a multilevel puncturing scheme that solves the problem of symbol-by-symbol adaptive puncturing and interleaving. The equivalent distance spectrum for variable rate symbol-by-symbol adaptive codes is introduced and analytical bounds on adaptive codes are derived that enable us to determine the optimal adaptation thresholds. Two operation modes, namely constant throughput and constant bit error rate (BER) controls, are proposed. It is found that there are significant gains relative to fixed-rate coding in terms of signal-to-noise ratio (SNR) and throughput. It is also found that the ABICM scheme is essentially not degraded when used with small interleaving depths. This makes the ABICM very suitable for real-time applications.
Isolation and Characterization of Novel Endogenous Digitalis-like Factors in the Ovary of the Giant Toad, <i>Bufo</i> <i>m</i><i>arinus</i> (1998)

We have previously described the structures of four novel unconjugated bufadienolides in the ovary of the toad, Bufo marinus. In this study, we report the separation and characterization of three novel bufadienolide conjugates. These compounds were purified by HPLC, and their structures were determined to be 11alpha, 19-dihydroxytelocinobufagin-3-(12-hydroxydodecanoic acid) ester, 11alpha,19-dihydroxytelocinobufagin-3-(14-hydroxy-7-tetra decenoic acid) ester, and 11alpha, 19-dihydroxytelocinobufagin-3-(14-hydroxytetradecanoic acid) ester on the basis of NMR and MS data. Numerous dicarboxylic acid esters of bufadienolides have previously been described, but the three bufadienolide conjugates described in this report differ from previously described esters in that they contain hydroxylated monocarboxylic acids. The function of these three conjugates is not known but they are, like bufotoxins, potent inhibitors of Na+, K+-ATPase and may play a developmental role in the differentiation of toad oocytes.
Impact of Gene Polymorphisms on Clinical Outcome for Stage IV Melanoma Patients Treated with Biochemotherapy: An Exploratory Study (2005)

Cytokine gene polymorphisms predicted clinical outcome for advanced melanoma patients who received biochemotherapy. The combined effects of multiple genetic polymorphisms may provide more accurate prognostic information. Additional independent studies are needed to confirm these pilot findings.
Product control in catalytic aromatization of C2+ hydrocarbons (2007)

Aromatization of light hydrocarbons (propane, butane, propane-propene mixture, and cat-cracker off-gases) on ZnO-zeolite and lanthanide-zeolite catalysts based on zeolite TsVM (SiO2/Al2O3 = 62) and industrial catalyst SGK-1 was studied. It was shown that the modification of catalysts with lanthanides leads to an increase in both the total yield of xylenes and the p-xylene selectivity, a change that is explained by the formation of branched intermediates and steric specifics of their further conversion.
222. AST-VAC2: An Embryonic Stem Cell-Derived Dendritic Cell Cancer Immunotherapy (2015)

AST-VAC2 is a cancer immunotherapy product comprising embryonic stem cell-derived dendritic cells electroporated with an mRNA encoding a telomerase/lysosome-associated membrane protein 1 (LAMP hTERT) chimeric tumor antigen. Previous studies have shown that AST-VAC2 can elicit a telomerase-specific T-cell response from partially HLA-matched donor peripheral blood mononuclear cells. A related product (AST-VAC1), an autologous dendritic cell/LAMP hTERT cancer immunotherapy, has been tested in clinical trials on patients with prostate cancer or acute myeloid leukemia. The AST-VAC1 treatment was well tolerated and generated anti-telomerase immune responses. AST-VAC2 is being developed as an off-the-shelf allogeneic cancer vaccine for clinical testing in partially HLA matched patients with non-small cell lung carcinoma. The AST-VAC2 product is derived from the H1 human embryonic stem cell line. The stem cells are differentiated into mature dendritic cells in a multi-step process via embryoid bodies, prepared growth surfaces and specific growth factors. The differentiation process requires 34 days in culture. The cells are then electroporated with the LAMP hTERT mRNA and irradiated prior to cryopreservation. In preparation for clinical testing the manufacturing process has been scaled up from T-flasks to large surface area cell stacks. This has required a number of novel process modifications including large scale embryoid body filtration and flow-through electroporation. The final product will be rendered incapable of replication by gamma irradiation. The radiation dose required for halting replication while still preserving antigen presentation was determined using a combination colony formation/potency assay. It is anticipated that the proposed Phase 1/2a clinical trial will enroll approximately 30 patients and will include both a dose escalation and a broadening of inclusion criteria to permit an assessment of safety, toxicity and immunogenicity in patients with advanced disease. Asterias has recently partnered with Cancer Research United Kingdom (CRUK) and the University of Southampton for the GMP manufacturing and initial clinical testing of AST-VAC2 in the UK.
LiNbO3 optical waveguides by Zn diffusion from vapor phase (1995)

Fabrication of optical waveguides on LiNbO3 by Zn diffusion from the vapor phase has been demonstrated, using a specially designed diffusion apparatus. The planar waveguides on z-cut samples support both TE and TM propagations, indicating an increase of refractive indices for n0 and ne. Energy dispersive x-ray analysis measurements confirm the diffusion of Zn into the crystal, and analysis of the content of Zn as a function of diffusion depth for samples treated at different temperatures indicates much higher diffusion coefficients than those obtained for Ti diffusion in LiNbO3. The technique is versatile, easy to operate, and allows fabrication of waveguides at temperatures as low as 600–700 °C, thus preventing Li outdiffusion.
Antifungal effect of 5‐aminolevulinic acid PDT in <i>Trichophyton rubrum</i> (2005)

In the present investigation, we have shown for the first time that the onychomycosis-inducing dermatophyte Trichophyton rubrum was able to metabolize 5-aminolevulinic acid (ALA) to protoporphyrin IX (PpIX) in liquid culture medium. We have established and optimized the culture conditions and could show the typical PpIX-induced red fluorescence which was evaluated qualitatively by Wood's light examination and fluorescent microscopic analysis. The optimum concentration of ALA was in the range of 1-10 mmol l(-1). If used in higher concentrations, ALA leads to a significantly reduced growth rate and absence of PpIX formation due to highly acidic conditions. The first observation of red fluorescence was detected between 10 and 14 days poststimulation with ALA, increasing thereafter. Fluorescent microscopic examinations demonstrated that formation of PpIX was restricted to selected parts of the fungal mycelium. Repeated application of ALA in order to achieve the highest formation of PpIX in T. rubrum failed, probably due to the sustained low pH values. ALA treatment and irradiation of T. rubrum clearly demonstrated the growth-inhibiting effect of ALA PDT, either leading to reduced numbers of colonies or reduced diameters of single fungal colonies. Summarizing our results, ALA PDT might be a promising approach in the reduction of T. rubrum colonization in onychomycosis.
海平面科学理解潮汐、风暴潮、海啸和平均海平面的变化 (2016)

全球大约一半的人口居住在离海岸100公里范围以内，大约90％的运输依靠海运。海平面变化对人类的生产和生活有着重要影响。海平面变化从空间上看既有局部性的也有全球性的，从时间上看从日际变化到世纪的长期变化。
An Effective Technique to Integrate Core and Wireline NMR Log Data through Relaxivity Grouping or NMR Facies Identification (1999)

Abstract Interpretation of nuclear magnetic resonance (NMR) logs is challenged by the following three factors (1) incpnrect-critical T2 cutoff foF free fluid index (2) incorrect permeability model and (3) effect of unusual.relaxivity properties of the rock on relaxation times. Some of these challenges can be addressed through the use of NMR core spectrometry data for log calibration. The major difficulty lies in the ability or inability to apply the core data correctly in log calibration. In this work, we demonstrate that the identification and delineation of NMR relaxivity group or NMR facies are critical in the application of laboratory NMR calibration data to log analysis. The method presented also allows direct application of laboratory-based model for log interpretation irrespective of tool-dependent factors like logging speed, borehole conditions, fluid types and saturation. In developing this technique, the following were taken into consideration (1), the fundamental physics of the behaviour of the magnetic dipole of hydrogen nuclei in the presence of an applied (external) magnetic field, (2), the mathematical relationship between the relaxation rates of magnetisation, the pore size that contain the liquid and other surface properties of the porous media, and (3), the mineralogital attributes of the formation. We define NMR facies as units in the reservoir that have similar NMR relaxation characteristics. These units are delineated into groups referred to as relaxivity groups. Each relaxivity group has similar T2 cut off and relaxivity product. The combined influence of mineralogicai and textural attributes on relaxation rate is captured in this method. Delineation of these groups is based on NMR porosity and normalised median value of the relaxation time, T2m. These data can be obtained directly from NMR log data. The validity and applicability of the methodology is demonstrated by a regional study of NMR transverse relaxation time constant T2. Measurement were carried out on over 400 core plugs, and mineralogical, textural and pore size attributes on selected samples. The benefits of NMR relaxivity grouping include: Basis for tool calibration and enhanced interpretation of NMR log output. Algorithm for permeaoility and residual oil saturation determination.
Protecting private cloud located within public cloud (2013)

Many studies use cryptographic technologies to protect sensitive data in public cloud. However, these approaches may introduce large overheads. Recently, hybrid cloud started to gain a lot of attentions. A hybrid cloud consists of a private cloud and a public cloud. Hybrid cloud allows users to store sensitive data in their private cloud and hence enables efficient and secure data outsourcing. In this paper, we consider a new hybrid cloud model “Cloud-in-Cloud” (CIC). Our CIC model uses a new architecture to form a hybrid cloud: placing a small number of private computers (i.e., a small private cloud) within a public cloud. The private cloud can be used to store sensitive user data. Furthermore, it is within the public cloud, so the communications between private and public clouds have small overhead. And then we study how to protect a private cloud that locates within a semi-trusted environment. We present two methods that can detect attacks that try to obtain data and information in the private cloud. Our methods are able to efficiently detect physical attacks, such as the cold boot attack and the USB autorun attack. Experimental results show that our methods have small overhead.
Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation (2001)

The genetic program through which a specific transcription factor regulates a biological response is fundamental to our understanding how instructions in the genome are implemented. The emergence of DNA microarray technology for gene expression analysis has generated vast numbers of target genes resulting from specific transcription factor activity. We use the oncogenic transcription factor c-Myc as proof-of-principle that human genome sequence analysis and scanning of a specific gene by chromatin immunoprecipitation can be coupled to identify target transcription factor binding sequences. We focused on nucleophosmin, also known as B23, which was identified as a candidate Myc-responsive gene from a subtractive hybridization screen, and we found that sequences in intron 1, and not 5' sequences in the proximal promoter, are bound by c-Myc in vivo. Hence, a scanning chromatin immunoprecipitation (SChIP) strategy is useful in analyzing functional transcription factor-binding sites.
Sequence and properties of <i>mecA</i>, a negative regulator of genetic competence in <i>Bacillus subtilis</i> (1993)

The development of competence in Bacillus subtilis is regulated by growth conditions and several regulatory genes. In complex media competence development is poor, and there is little or no expression of late competence genes. mec mutations permit competence development and late competence gene expression in complex media, and bypass the requirements for many of the competence regulatory genes. In this paper we describe the cloning and characterization of mecA. The mecA gene product acts negatively in the development of competence. Null mutations in mecA allowed expression of a late competence gene comG, under conditions where it is not normally expressed, including in complex media and in cells mutant for several competence regulatory genes. Overexpression of MecA from a multicopy plasmid resulted in inhibition of comG transcription. The DNA sequence of mecA was determined and the predicted gene product showed no significant similarity to any protein in the database. Expression of a mecA-lacZ translational fusion was constitutive during growth and did not vary significantly in the different media tested. The role of mecA in competence development and other stationary phase phenomena is discussed.
THE EFFECT OF METHYL CYANOACRYLATE TISSUE ADHESIVE ON THE HUMAN FALLOPIAN TUBE AND ENDOMETRIUM (1972)

Summary When the liquid tissue adhesive methyl‐2‐cyanoacrylate polymerized on the endometrium and Fallopian tube lining a temporary localized histotoxic effect was produced. The toxicity was confined to the superficial layers of cells which underwent round cell infiltration followed by fibrous tissue replacement with loss of the original epithelium. The thickness of secretory endometrium prevented damage to the basal layers and allowed the endometrium to regenerate. The basal layers of proliferative endometrium were involved in the inflammation and the endometrium did not regenerate. In the Fallopian tube the lining epithelium was permanently lost at all stages of the menstrual cycle and the tube lumen was obliterated. The polymer was eliminated from the genital tract within 16 weeks. The authors suggest that the transcervical technique of instillation described here may be developed (a) to control persistent menorrhagia, and (b) to offer a method of permanent sterilization in women comparable in ease to the insertion of an intrauterine contraceptive device.
Stimuli-Responsive Polymer Nanocomposites Inspired by the Sea Cucumber Dermis (2008)

Sea cucumbers, like other echinoderms, have the ability to rapidly and reversibly alter the stiffness of their inner dermis. It has been proposed that the modulus of this tissue is controlled by regulating the interactions among collagen fibrils, which reinforce a low-modulus matrix. We report on a family of polymer nanocomposites, which mimic this architecture and display similar chemoresponsive mechanic adaptability. Materials based on a rubbery host polymer and rigid cellulose nanofibers exhibit a reversible reduction by a factor of 40 of the tensile modulus, for example, from 800 to 20 megapascals (MPa), upon exposure to a chemical regulator that mediates nanofiber interactions. Using a host polymer with a thermal transition in the regime of interest, we demonstrated even larger modulus changes (4200 to 1.6 MPa) upon exposure to emulated physiological conditions.
Preuss Resident Research Award: maximal resection of low-grade intrinsic brain tumors using "awake" craniotomy and multiple marginal smear biopsies: neurological deficit rate and long-term survival data. (2006)

INTRODUCTION “Awake” craniotomy with multiple marginal biopsies was used to resect 154 presumed low-grade brain tumors. Intraoperative neurological deficits were more likely to be permanent (47.1%) than those detected postoperatively (12.5%). The permanent, significant neurological deficit rate was 6.5%. The survival rate for Grade 2 lesions was 65.1% (43 patients) at 10 years and 85.9% (71 patients) at 5 years. Survival was better after total resection.
형산강(兄山江)의 어류상(魚類相)에 관(關)하여 (1980)

For the study on the ichthyfauna of the Hyeong San River, 945 individuals of freshwater fishes were collected during the period from April 1978 to April 1980. And the results of this study are as fallows. 1. The authors obtained 945 individuals of fishes which classified into 37 species, 29 genera, 10 families, 7 orders belong to two classes by use of cast nets and scoop nets in this river. 2. The fresh water fishes from the Hyeong San River are arranged in 43 species, 32 ge-nera, 13 families, 7 orders belong to two classes according to the previous papers and the collections by the authors. 3. The following 19 species are reported briefly hitherto as unrecorded species from the Hyeong San River: Cobitis taenia, Cobitis koreensis, Cobitis longicorpus, Misgurnus anguillicaudatus, Misgurnus mizolepis, Lefua costata, Liobagrus mediadiposalis, Anguilla japonica, Pun-gilius pingitius sinensis, Oryzias latipes, Mugil cephalus, Channa argus, Lepomis mac-rochirus, Gobius fuscus, Gobius gymnauchen, Rhinogobius sp. Caenogobius annularis, Chasmichthys dolichognathus, Tridentiger obscurus. 4. The next five fishes from this river are specific species to Korea in the workd: Squalidus coreanus, Pseudoperilampus uyekii, Cobitis koreensis, Cobitis longicorpus, Liobagrus mediadiposalis.
Security Vulnerabilities Detected in Medical Devices (2020)

The increasingly close connection between medical devices and computer networks has given rise to novel cybersecurity threats. Due to the elevated number of connected medical devices, this means that more opportunities for security vulnerabilities exist. To safeguard against cybersecurity breaches in medical devices, understanding the complex nature of the operational surroundings is essential, and knowing about each technical susceptibility is valuable. The purpose of this paper is to discuss a network model of medical devices. Security vulnerabilities in the devices, as well as potential methods of attack, were examined. A solution is provided to improve the security of IT systems, due to essential role medical devices play in patient outcomes.