gebhart/patrepeval huggingface dataset:
BONE MARROW TRANSPLANTATION ACROSS MAJOR HISTOCOMPATIBILITY BARRIERS IN MICE EFFECT OF ELIMINATION OF T CELLS FROM DONOR GRAFTS BY TREATMENT WITH MONOCLONAL THY-1.2 PLUS COMPLEMENT OR ANTIBODY ALONE (1981)

The current studies were designed to evaluated optimal conditions for reduction of graft-versus-host disease (GVHD) by removal of donor T cells from bone marrow inoculum. A model was used in which the addition of spleen cells to donor marrow heavily favored the development of lethal GVHD. Treatment of donor bone marrow plus spleen cells with monoclonal anti-Thy-1.2 antibody plus complement protected lethally irradiated recipients from GVHD across major histocompatibility barriers better than donor cells treated with the same dilution of antibody alone. Engraftment was demonstrated by the presence of high percentages of donor cells in the peripheral blood of these animals and the long-term survival of donor skin grafts. These results may be important in light of the development of new antihuman T cell monoclonal antibodies which may be used in the treatment of donor marrow in clinical transplantation.
Studies on Tannin Acyl Hydrolase of Microorganisms (1968)

Tannin acyl hydrolase (Tannase) from Asp. oryzae No. 7 was purified. The purified enzyme was homogenous on column chromatography (DEAE-Sephadex A50, Sephadex G100), ultra centrifugation and electrophoresis. The molecular weight of the enzyme estimated by gel filtration method was about 200, 000. The enzyme was stable in the range of pH 3 to 7.5 for 12 hr at 5°C, and for 25 hr at the same temperature in the range of pH 4.5 to 6. The optimum pH for the reaction was 5.5. It was stable under 30°C (over one day, in 0.05 M-citrate buffer of pH 5.5), and the optimum temperature was 30_??_40°C (reaction for 20 min). The activity was lost completely at 55°C in 20 min at pH 5.5, or at 85°C in 10min at the same pH. Any metal salt tested did not activate the enzyme. Zink chloride and cupric chloride inhibited the activity or denatured the enzyme. The activity was lost completely by dialysis against EDTA-solution at pH 7.25, although it was not affected by dialysis against deionized water.
Development of a Mechanistic Foam Simulator: The Population Balance and Generation by Snap-Off (1988)

Summary The mobility of a foam depends heavily on its texture, which is the distribution of bubble sizes in the dispersion. To incorporate this variable in a mechanistic simulator, the usual conservation equations are coupled with balances on the densities of flowing and stationary bubbles in the foam. This approach to modeling foam flow is illustrated with a simulation of a displacement in which foam is generated in situ by capillary snap-off.
Integrated Al_2O_3:Er^3+ ring lasers on silicon with wide wavelength selectivity (2009)

Integrated Al(2)O(3):Er(3+) channel waveguide ring lasers were realized on thermally oxidized silicon substrates. High pump power coupling into and low laser output power coupling from the ring is achieved in a straightforward design. Output powers of up to 9.5 microW and slope efficiencies of up to 0.11% were measured while lasing was observed for a threshold diode-pump power as low as 6.4 mW for ring lasers with cavity lengths varying from 2.0 to 5.5 cm. Wavelength selection in the range 1530-1557 nm was demonstrated by varying the length of the output coupler from the ring.
The value of palpation, varicoscreen contact thermography and colour Doppler ultrasound in the diagnosis of varicocele (1996)

Three non-invasive methods for the detection of a varicocele were evaluated in 63 men presenting with infertility. Physical examination, varicoscreen contact thermography and colour Doppler ultrasound were compared with spermatic venography as reference strategy. Physical examination had a sensitivity of 71%. Whether the non-palpable varicoceles are all subclinical is questionable since the specificity of physical examination was 69%. Varicoscreen proved be quick, easy and cheap but of no clinical value (sensitivity 97%, specificity 9%). Colour Doppler ultrasound using strict criteria was a good diagnostic tool (sensitivity 97%, specificity 94%). No imaging difference was seen with colour Doppler ultrasound among clinical and subclinical varicoceles. Since the debate on treating all degrees of varicocoeles is ongoing, we suggest that Doppler sonography should be a routine examination in infertile men.
Efficient in vivoknock-down of estrogen receptor alpha: application of recombinant adenovirus vectors for delivery of short hairpin RNA (2006)

Ad mediated transfer of shERalpha expression constructs results in efficient and specific knockdown of endogenous ERalpha transcription both in vitro and in vivo.
Knudsen force based MEMS structures (2014)

Knudsen forces are gas molecular forces which originate from the differential temperatures in rarefied gases. We report measurements of these forces at normal ambience on test structures made by surface micromachining of polysilicon. Using these results, a surface micromachined Knudsen vacuum sensor has been simulated, fabricated and characterized. The vacuum sensor has an area of 1 mm2. The fabricated device has a sensitivity of 40 fF Pa−1 in the pressure range of 0.1–10 Pa. The measured data is analysed and the magnitude of the Knudsen's force is extracted. The paper also suggests ways to enhance the range and improve the sensitivity of such sensors.
Control Architecture for Robot Cells to Enable Plug'n'Produce (2007)

This paper deals with the concept of a control architecture for robot cells that enables plug'n'produce according to plug'n'play in the office world. To achieve this, a software module called "interconnector module" takes as input descriptions of devices and processes. These descriptions are then automatically evaluated in order to offer the user commands to use the functionality of the robot cell in its current setup. The evaluation consists of several steps that are processed in different sub-modules of the interconnector module. In this paper the concept of this interconnector module is introduced.
Journeys through a research landscape :Lessons in multi-partner research (2007)

Through the stories of project participants, this paper documents and describes the complexity of doing multi-partner research.Added to this complexity in Linking Worlds is the difficulty of working with partners over vast geographical distances.These stories deal with the new problems, new roles and new strategies that emerged from the research landscape and as such address the issues of project governance, management and administration.What emerges from these stories is the imperative for multi-partner research to be based on openness and flexibility, especially in relation to issues of power and control.The
Votrax real time hardware for phoneme synthesis of speech (2005)

A real time phonetic voice synthesizer roughly the size of a small hi-fi amplifier has been developed. It accepts a string of phoneme commands, each consisting of 8 bits. 6 bits determine the phoneme uttered while 2 bits determine the inflection associated with that phoneme. The synthesizer contains an active filter network which simulates the transfer function of the human vocal tract. This analog network is excited by both voicing and fricative sound sources. The sound sources and the vocal tract filter transfer function are dynamically manipulated in response to the numerous phoneme command sequences to produce articulatory synthesis by rule.
Performance of single carrier transmission with cooperative diversity over fast fading channels (2009)

Space-time block coded (STBC) single carrier (SC) transmission was extended in a distributed fashion for practical implementation of user cooperation. However, STBC was designed under the assumption that the channel is static over the duration of a space-time codeword. Thus, the distributed STBC SC system suffers from the time selectivity of wireless fading channels. To achieve a reliable performance over fast fading channels, we propose a distributed space-frequency block coded (D-SFBC) SC transmission. This paper analytically compares the performance of these two distributed SC transmissions over fast fading environment. For evaluation of mean square error (MSE) over fast fading channels, we present a channel model that captures the time-varying nature of wireless channels. It gives an insight into the characteristics of inter-carrier interference and simplifies the evaluation of MSE. Using this model, it is proven that the D-SFBC SC transmission outperforms the D-STBC SC transmission when there exists a severe Doppler spread. Simulation results are also provided to validate our analysis and to compare two distributed single carrier transmission schemes.
Design, Synthesis, and Characterization of Bismaleimide Co-Curing Elastomers (2012)

Isobutylene-rich elastomers bearing functional groups that engage N-arylmaleimides in C–H bond addition and/or alternating copolymerization are described. While inactive to cross-linking when treated at high temperature with peroxide alone, these co-curing elastomers can be cross-linked substantially when combined with bismaleimide coagents such as N,N′-m-phenylenedimaleimide (BMI). Poly(isobutylene-co-isoprene) (IIR) samples containing relatively high amounts of residual isoprene unsaturation are shown to provide relatively low coagent cure reactivity, whereas IIR derivatives bearing pendant polyether or vinyl ether functionality are shown to provide exceptional cross-linking rates and extents when treated with identical BMI formulations. The design of such co-curing elastomers is discussed, along with the physical properties of the resulting vulcanizates.
Web-based issue tracking for large software projects (1998)

Many problems are found and fixed during the development of a software system. The Project Issue Tracking System toolkit, a Web-based issue-management tool, can be used to organize issue reports during development and to communicate with different project teams around the world. The Project Issue Tracking System (PITS) is a tool that supports the IV&V effort for two major NASA projects: the Earth Observation System Data and Information System (EOSDIS) and the Earth Science Data and Information System (ESDIS). The EOSDIS IV&V effort teams several companies and organizations at several sites with Intermetrics, Inc, serving as the lead contractor. We examine the PITS Web-based mechanisms for tracking issue reports.
Enzymatic Oxidation Polymerization of <i>o</i>-Phenylenediamine (1992)

Abstract Enzymatic oxidation polymerization of o-phenylenediamine using horseradish peroxidase as a catalyst was carried out in an aqueous organic solvent. Polymeric materials with average molecular weight of 20 000 were obtained. The structure of the polymer was found to be composed mainly from imino-2-aminophenylene unit from 13C NMR analysis.
New Insights into Chitosan−DNA Interactions Using Isothermal Titration Microcalorimetry (2009)

The interaction of chitosan with plasmid DNA was investigated as a function of pH, buffer composition, degree of deacetylation (DDA), and molecular weight (M(n)) of chitosan, using isothermal titration microcalorimetry (ITC). The Single Set of Identical Sites model was used to obtain the enthalpy of interaction, the binding constant, and the stoichiometry of binding. The chitosan-DNA interaction was shown to be coupled with proton transfer from the buffer to chitosan, as revealed by the dependence of the measured heat release on the ionization enthalpy of the buffer. The measured enthalpy of binding was almost entirely due to proton transfer, because it was accounted for by the enthalpy of ionization of the buffer and of chitosan once the number of protons transferred was calculated. This proton transfer during binding resulted in the protonation of an additional 17, 37, and 58% of total glucosamine units at pH 5.5, 6.5, and 7.4, respectively. The strong polyanionic nature of DNA facilitates the ionization of glucosamines of chitosan upon complexation and is responsible for proton transfer. Interestingly, using the chitosan-DNA stoichiometry provided by ITC and the calculated degree of ionization of chitosan in the complex, the charge ratio of protonated amines to negative phosphate groups in the complex was nearly constant at 0.50-0.75 after saturation and was independent of the pH, buffer type and chitosan molecular characteristics. The chitosan-DNA binding constant was in the range of 10(9)-10(10) M(-1). The binding constant was pH-dependent and was greater at lower pH due to increased electrostatic attraction to DNA when chitosan is highly charged. Furthermore, the DDA and molecular weight of chitosan exerted a great influence on binding affinity which increased by almost an order of magnitude with an increase of the latter from 7 to 153 kDa. The binding affinity did not change significantly with DDA from 72 to 80% when the M(n) was kept constant near 80 kDa, but it increased substantially with DDA from 80 to 93% to reach a value similar to that obtained with chitosan of M(n) = 153 kDa and 80% DDA. These results provide insight into the previously reported dependence of the transfection efficiency of DNA/chitosan complexes on chitosan DDA and molecular weight, where complex stability and chitosan-DNA binding strength play a critical role.
Graph-Based Optimization with Tubularity Markov Tree for 3D Vessel Segmentation (2013)

In this paper, we propose a graph-based method for 3D vessel tree structure segmentation based on a new tubularity Markov tree model (TMT), which works as both new energy function and graph construction method. With the help of power-watershed implementation [7], a global optimal segmentation can be obtained with low computational cost. Different with other graph-based vessel segmentation methods, the proposed method does not depend on any skeleton and ROI extraction method. The classical issues of the graph-based methods, such as shrinking bias and sensitivity to seed point location, can be solved with the proposed method thanks to vessel data fidelity obtained with TMT. The proposed method is compared with some classical graph-based image segmentation methods and two up-to-date 3D vessel segmentation methods, and is demonstrated to be more accurate than these methods for 3D vessel tree segmentation. Although the segmentation is done without ROI extraction, the computational cost for the proposed method is low (within 20 seconds for 256{*}256{*}144 image).
The nature of dielectric breakdown (2008)

Dielectric breakdown is the process of local materials transiting from insulating to conductive when the dielectric is submerged in a high external electric field environment. We show that the atomistic changes of the chemical bonding in a nanoscale breakdown path are extensive and irreversible. Oxygen atoms in dielectric SiO2 are washed out with substoichiometric silicon oxide (SiOx with x&lt;2) formation, and local energy gap lowering with intermediate bonding state of silicon atoms (Si1+, Si2+, and Si3+) in the percolation leakage path. Oxygen deficiency within the breakdown path is estimated to be as high as 50%–60%.
Acousto-optical Filter Can Rapidly Tune Solid-State Lasers (1991)

Incorporation of acousto-optical tunable filter (AOTF) in cavity of solid-state laser, provides means of adjusting wavelength of laser output electronically, according to recent proposal. Output wavelength randomly selected in microseconds. Technique useful in remote-sensing applications, such as in differential-absorption lidar (DIAL) and in communications for wavelength-division multiplexing.
Nb‐Doped VO<sub>2</sub> Thin Films Prepared by Aerosol‐Assisted Chemical Vapour Deposition (2007)

Abstract Niobium‐doped vanadium dioxide (V x Nb 1– x O 2 , x = 0–0.037) thin films were prepared by aerosol‐assisted chemical vapour deposition (AACVD) of vanadyl(IV) acetonate and niobium(V) ethoxide in ethanol. Samples were analysed by EDX, XRD, Raman, XPS and SEM. The analyses confirmed the deposition of niobium, even if no separated phase was formed; the morphological structure of the films was affected by the dopant presence. The thin films showed thermochromic behaviour, with a marked change in optical properties above and below the switching temperature. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Some Reactions of Arylstibonic Acids (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Reactions of Arylstibonic AcidsG. O. Doak and Harry G. SteinmanCite this: J. Am. Chem. Soc. 1946, 68, 10, 1989–1991Publication Date (Print):October 1, 1946Publication History Published online1 May 2002Published inissue 1 October 1946https://pubs.acs.org/doi/10.1021/ja01214a034https://doi.org/10.1021/ja01214a034research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Corneoscopy in Keratorefractive Surgery (1983)

Map topography of the cornea allows the surgeon to determine discrete areas of the corneal topography which contribute to astigmatism or refractive error. Microsurgical repair of these disparate corneal areas may be documented quantitatively. We present a method of corneal topography analysis using the corneascope and high resolution digitization analysis of the resultant photographs. Cold-plated steel balls of known radius of curvature are the calibration standards to develop the linear regression analysis presented. Data storage, acquisition, and comparison to subsequent photographs to determine minute topographical shifts is greatly facilitated by this new technique.
Crystallization processes in poly(ethylene terephthalate) as modified by polymer additives and fiber reinforcement (1994)

Abstract The effect of fiber reinforcement on the crystallization kinetics of poly(ethylene terephthalate), or PET, was investigated using differential scanning calorimetry. The objective of the study was to determine how the effects of fiber reinforcement on PET crystallization are modified by the presence of polymer nucleating and plasticizing additives. Undirectional fiber composites were prepared using aramid and glass fibers in PET. The rate of crystallization of PET, as reflected by crystallization half‐time, is seen to depend on reinforcing fiber type, crystallization temperature, and presence of nucleant or plasticizer. Howerver, degree of crystallinity of PET is largely unaffected by the presence of additives and reinforcing fibers. Crystallization kinetics are analyzed using the Avrami model for PET volume crystallized as a function of time. Avrami plots for PET and fiber‐reinforced PET exhibit two linear regions, possibly corresponding to primary and secondary crystallization. The crystalline morphology of fiber‐reinforced PET was also studied using polarized light microscopy. Results concerning nucleation density and growth morphology are used in explaining differences seen in crystallization kinetics in fiber‐reinforced systems. © 1994 John Wiley & Sons, Inc.
Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family (1990)

Inner membrane Tet proteins encoded by tet genes in gram-negative bacteria mediate resistance to tetracycline (Tcr) by directing its export. Total sequences for class A, B, and C tet genes demonstrate that their products have a common ancestor, with Tet(A) and Tet(C) being more closely related (78% identical) than either is to Tet(B) (45% identical). The N- and C-terminal halves of Tet(B) and Tet(C) appear to comprise separate domains, and trans-complementation observed between tetracycline sensitive mutants in either domain of Tet(B) suggests separate but interactive functions for these domains. In this present study, interdomain hybrid genes were constructed to express hybrid tet products whose N- and C-terminal halves were derived from different family members [Tet(A/C), Tet(B/C), and Tet(C/B)]. Tet(A/C) specified a level of Tcr comparable to wild-type Tet(C) and 60% that of Tet(A), indicating that domains from these closely related tet products can function in cis. Although neither Tet(B/C) nor Tet(C/B) hybrids conferred significant Tcr, cells producing both of these types of hybrid proteins expressed substantial Tcr, indicating that productive interactions can occur in trans between Tet(B/C) and Tet(C/B). Taken together, these results suggest that highly specific interactions between the N- and C-terminal domains are necessary for Tcr and do not occur in individual hybrids derived from the more distant relatives, Tet(B) and Tet(C). This requirement for specific interactions suggests that N- and C-terminal domains have coevolved in each member of the Tet family.
Fast live-cell conventional fluorophore nanoscopy with ImageJ through super-resolution radial fluctuations (2016)

Despite significant progress, high-speed live-cell super-resolution studies remain limited to specialized optical setups, generally requiring intense phototoxic illumination. Here, we describe a new analytical approach, super-resolution radial fluctuations (SRRF), provided as a fast graphics processing unit-enabled ImageJ plugin. In the most challenging data sets for super-resolution, such as those obtained in low-illumination live-cell imaging with GFP, we show that SRRF is generally capable of achieving resolutions better than 150 nm. Meanwhile, for data sets similar to those obtained in PALM or STORM imaging, SRRF achieves resolutions approaching those of standard single-molecule localization analysis. The broad applicability of SRRF and its performance at low signal-to-noise ratios allows super-resolution using modern widefield, confocal or TIRF microscopes with illumination orders of magnitude lower than methods such as PALM, STORM or STED. We demonstrate this by super-resolution live-cell imaging over timescales ranging from minutes to hours.