gebhart/patrepeval huggingface dataset:
A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome (1993)

Chromosomal aneusomy is a major cause of reproductive wastage and congenital malformations in man. Zinc finger encoding genes would be good candidates for being involved in the multiple developmental defects associated with chromosomal aneusomy--by virtue of their role as transcriptional regulators, their abundance in the genome and their known association with specific developmental disorders. We have isolated and mapped a zinc finger encoding cDNA (ZNF141) of the C2-H2/KRAB subfamily to the 4p- (Wolf-Hirschhorn) syndrome (WHS) chromosome region. ZNF141 mapped to the distal end of the 2.2 Mb smallest region of deletion overlap of WHS, 300 kb from the 4p telomere on cosmid CD1 defining the anonymous locus D4S90. ZNF141 was expressed ubiquitously at low levels in the analysed tissue. The identification of a candidate gene for a chromosomal aneusomy syndrome belonging to a class of evolutionary conserved genes will provide options for studying its normal and abnormal expression during mammalian embryogenesis.
Core−Shell Materials Elaboration in Supercritical Mixture CO<sub>2</sub>/Ethanol (2000)

Supercritical fluids exhibit a range of unusual properties that can be exploited for developing new processes. In this paper a new way for particle coating is presented. It consists of depositing on a core particle a thin layer of a material based on copper in a supercritical medium. Two examples are described: a deposit of Cu on nickel particles and a deposit of Cu on particles of permanent magnet SmCo5. In both cases the copper source is bis(hexafluoroacetylacetonate)copper(II), which is thermally decomposed in the supercritical mixture CO2/ethanol. This process allows one to obtain new “core−shell structures”, Ni/Cu and SmCo5/Cu. New interesting properties are expected for these structures, more particularly in the magnetic recording field.
Development of an Optical Gas Leak Sensor for Detecting Ethylene, Dimethyl Ether and Methane (2013)

In this paper, we present an approach to develop an optical gas leak sensor that can be used to measure ethylene, dimethyl ether, and methane. The sensor is designed based on the principles of IR absorption spectrum detection, and comprises two crossed elliptical surfaces with a folded reflection-type optical path. We first analyze the optical path and the use of this structure to design a miniature gas sensor. The proposed sensor includes two detectors (one to acquire the reference signal and the other for the response signal), the light source, and the filter, all of which are integrated in a miniature gold-plated chamber. We also designed a signal detection device to extract the sensor signal and a microprocessor to calculate and control the entire process. The produced sensor prototype had an accuracy of ±0.05%. Experiments which simulate the transportation of hazardous chemicals demonstrated that the developed sensor exhibited a good dynamic response and adequately met technical requirements.
Intelligent Information Agents for the World Wide Web (2003)

This paper provides a snapshot of the current status of Intelligent Information Agents for the World Wide Web (WWW). This area is still in its infancy, but, like the Web itself, is undergoing rapid change. Software agents are being employed in a variety of ways on the Web and elsewhere. However, we focus here on agents that accomplish tasks such as searching, browsing and filtering information available on the WWW. In addition, we discuss KQML and CORBA, enabling technologies that provide a framework for developing future software agents. INTRODUCTION The World Wide Web (WWW) contains a complete universe of on-line information. Unfortunately, it has become almost impossible for a casual user to look for specific information without getting lost among huge amounts of mixed data. Some problems are inherent in any information retrieval system. In particular, retrieval failures arise because of the the ambiguity of natural language. Queries are at best imperfect representations of the us...
Enhanced Hydrogen Storage Properties of Li−Mg−N−H System Prepared by Reacting Mg(NH<sub>2</sub>)<sub>2</sub> with Li<sub>3</sub>N (2009)

The Li−Mg−N−H system was prepared by reacting magnesium amide [Mg(NH2)2] with lithium nitride (Li3N) and investigated with regard to the hydrogen storage properties. Our study shows that the present method is superior to the conventional route in enhancing the reversible dehydrogenation properties. Through optimizing the Li3N:Mg(NH2)2 ratio in the starting materials, the reversible capacity of Li−Mg−N−H system increases to 4.9 wt %, 18% higher than that typically obtained from the Mg(NH2)2 + 2LiH mixture at 200 °C. Furthermore, increasing the Li3N:Mg(NH2)2 ratio is effective for mitigating the ammonia release from thus-prepared samples. Combined property/structure investigations indicate that the obtained enhancements should be ascribed to the effects of LiNH2 and LiH that were in situ generated from the excess Li3N. LiNH2 may promote the dehydrogenation reaction via seeding the reaction intermediate. The concurrently generated LiH acts as an effective ammonia trapping agent. These findings highlight the potential of “intermediate seeding” as a strategy to enhance the reversible hydrogen storage properties of metal−N−H systems.
Ground moving target indication by MIMO SAR with multi-antenna in azimuth (2011)

Ground moving target indication (GMTI) is of great important for surveillance and reconnaissance. The representative GMTI technique of along-track interferometry (ATI) synthetic aperture radar (SAR) does not take into account the fact that the stationary clutter unavoidably corrupts the interferometric phase of the targets. In this paper, we aim at multiple-input and multiple-output (MIMO) SAR-based solution. We proposed a scheme of MIMO SAR which is different from normal MIMO radar for ground moving targets detection and imaging. This approach employs MIMO along-track antenna configuration and waveform diversity. The system schemes, signal models, and waveform diversity are investigated.
Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell–Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma: Dose Expansion in a Phase I/II Trial (2022)

Subcutaneous epcoritamab resulted in deep and durable responses and manageable safety in highly refractory patients with large B-cell lymphoma, including those with prior CAR T-cell exposure.
Preparation of unnatural tellurium analogs of naturally occurring chromones and flavones. Control of ipso vs. ortho acylation, selective demethylation, and olefin-forming condensation reactions in benzo[b]tellurapyranones (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of unnatural tellurium analogs of naturally occurring chromones and flavones. Control of ipso vs. ortho acylation, selective demethylation, and olefin-forming condensation reactions in benzo[b]tellurapyranonesMichael R. DettyCite this: Organometallics 1988, 7, 10, 2188–2197Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/om00100a017https://doi.org/10.1021/om00100a017research-articleACS PublicationsRequest reuse permissionsArticle Views368Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Practical Guide to Usability Testing (1993)

From the Publisher:
In A Practical Guide to Usability Testing, the authors begin by defining usability, advocating and explaining the methods of usability engineering and reviewing many techniques for assessing and assuring usability throughout the development process. They then take you through all the steps in planning and conducting a usability test, analyzing data, and using the results to improve both products and processes. Written in plain English and filled with examples from many types of products and tests, A Practical Guide to Usability Testing discusses the full range of testing options from quick studies with a few subjects to more formal tests with carefully designed controls. The authors discuss the place of usability laboratories in testing as well as the skills you need to conduct a test. Included are forms that you can use or modify to conduct a usability test and layouts of existing labs that will help you build your own. The authors, a human factors psychologist and a linguist, have extensive experience conducting research on usability, doing usability testing, helping companies set up usability labs and programs, and teaching usability engineering and testing.
A Multiplexing Scheme for Multimodal Teleoperation (2017)

This article proposes an application-layer multiplexing scheme for teleoperation systems with multimodal feedback (video, audio, and haptics). The available transmission resources are carefully allocated to avoid delay-jitter for the haptic signal potentially caused by the size and arrival time of the video and audio data. The multiplexing scheme gives high priority to the haptic signal and applies a preemptive-resume scheduling strategy to stream the audio and video data. The proposed approach estimates the available transmission rate in real time and adapts the video bitrate, data throughput, and force buffer size accordingly. Furthermore, the proposed scheme detects sudden transmission rate drops and applies congestion control to avoid abrupt delay increases and converge promptly to the altered transmission rate. The performance of the proposed scheme is measured objectively in terms of end-to-end signal latencies, packet rates, and peak signal-to-noise ratio (PSNR) for visual quality. Moreover, peak-delay and convergence time measurements are carried out to investigate the performance of the congestion control mode of the system.
On the training strategies of neural networks for speech recognition (2003)

The authors investigate how to introduce invariant features to speech recognition neural networks using conventional back propagation (BP), K-neighbor interpolation training (KNIT) with a number of time-shifted examples (TSEs) of the same training sample. The TSEs are employed for training of a multilayer perceptron (MLP) and a time-delay neural network (TDNN) structure to enrich the training sample set covering a larger area of phoneme sample space. Speaker-dependent phoneme recognition experiments were performed. The advantages and disadvantages of using time-shifted examples of a training sample for a MLP and a TDNN structure and a BP and a KNIT algorithm are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Green Building Construction for Sustainable Future (2013)

Green building construction is relatively new phenomenon in Indian construction industry. With increasing awareness about global warming and climate change movement for sustainable development is gaining force. Indian Government also realizes the need for sustainable construction as its economy is growing at fast pace (7 to 8 percent annually) and that needs a rapid and vast infrastructure development. This paper provides a state of the art literature review on green building construction movement in India. This study provides an overview of green building rating systems, cost &amp; benefits, green design strategies, and discusses their implications for future of sustainable development in India. A need for widespread awareness about sustainable development and capacity building for design, construction and operations of green buildings is realized.
Work Centered Support System Design: Using Frames to Reduce Work Complexity (2002)

We have been developing user interface clients as fully integrated support systems. A Work Centered Support System aids work by using direct and indirect, passive and active methods. An important property of WCSS systems is the use of form representations as passive devices to help reduce work complexity while simultaneously aid users in adaptive problem solving. Based on our experience implementing the design of three WCSSs we have distilled a set of three form-based design principles that help insure a work-centered perspective is expressed in the interface and that aid problem solving. These principles connect problem-solving objects with work domain objects at different levels of abstraction, utilize a first-person work ontology, and organize information selection and layout based on problem relationships. This paper describes the principles and uses illustrations from our designs to indicate how they reduce work complexity.
Human discrimination of head-centred visual–inertial yaw rotations (2015)

To successfully perform daily activities such as maintaining posture or running, humans need to be sensitive to self-motion over a large range of motion intensities. Recent studies have shown that the human ability to discriminate self-motion in the presence of either inertial-only motion cues or visual-only motion cues is not constant but rather decreases with motion intensity. However, these results do not yet allow for a quantitative description of how self-motion is discriminated in the presence of combined visual and inertial cues, since little is known about visual-inertial perceptual integration and the resulting self-motion perception over a wide range of motion intensity. Here we investigate these two questions for head-centred yaw rotations (0.5 Hz) presented either in darkness or combined with visual cues (optical flow with limited lifetime dots). Participants discriminated a reference motion, repeated unchanged for every trial, from a comparison motion, iteratively adjusted in peak velocity so as to measure the participants' differential threshold, i.e. the smallest perceivable change in stimulus intensity. A total of six participants were tested at four reference velocities (15, 30, 45 and 60 °/s). Results are combined for further analysis with previously published differential thresholds measured for visual-only yaw rotation cues using the same participants and procedure. Overall, differential thresholds increase with stimulus intensity following a trend described well by three power functions with exponents of 0.36, 0.62 and 0.49 for inertial, visual and visual-inertial stimuli, respectively. Despite the different exponents, differential thresholds do not depend on the type of sensory input significantly, suggesting that combining visual and inertial stimuli does not lead to improved discrimination performance over the investigated range of yaw rotations.
Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guérin-infected mice (1997)

CD8+ T cells are essential for protection against mycobacteria, as is clearly demonstrated by the fatal outcome of experimental infection of beta-2 microglobulin knockout mice. However, the mechanisms and antigens (Ags) leading to CD8+ T-cell activation and regulation have been poorly characterized. Here we show that, upon immunization of major histocompatibility complex (MHC)-congenic mice with Mycobacterium bovis bacillus Calmette-Guérin (BCG), a cytotoxic response against BCG culture filtrate (CF) Ags (CFAgs) is induced in H-2b and H-2bxd haplotypes but not in H-2d haplotype. This response is mediated by CD8+ T cells and absolutely requires the activation of CD4+ T cells and their secretion of interleukin 2. The lack of cytotoxic response in H-2d mice cannot be explained by impaired cytokine production or by a defect in Ag presentation by H-2d macrophages. Using the MHC class I mutant B6.C-H-2bm13 mouse strain, we demonstrate that cytotoxic T lymphocytes (CTLs) recognize CFAgs exclusively in association with D(b) molecules. These Ags are cross-reactive in mycobacteria, since BCG-induced CTLs also recognize macrophages pulsed with CF from Mycobacterium tuberculosis H37Rv and H37Ra and from two virulent strains of M. bovis. Moreover, immunization with Mycobacterium kansasii induces CTLs able to lyse macrophages pulsed with BCG CF. Finally, we have found that these Ags can be characterized as hydrophilic proteins, since they do not bind to phenyl-Sepharose CL-4B. Our results indicate that MHC-linked genes exert a profound influence on the generation of CD8+ CTLs following BCG vaccination.
Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer (2015)

Potent EGFR downmodulation with Sym004 in patients with metastatic colorectal cancer and acquired resistance to cetuximab/panitumumab translates into significant antitumor activity and validates the preclinical hypothesis that a proportion of tumors remains dependent on EGFR signaling. Further clinical development and expanded correlative analyses of response patterns with secondary RAS/EGFR mutations are warranted.
Understanding and improving software build teams (2014)

Build, creating software from source code, is a fundamental activity in software development. Build teams manage this process and ensure builds are produced reliably and efficiently. This paper presents an exploration into the nature of build teams--how they form, work, and relate to other teams--through three multi-method studies conducted at Microsoft. We also consider build team effectiveness and find that many challenges are social, not technical: role ambiguity, knowledge sharing, communication, trust, and conflict. Our findings validate theories from group dynamics and organization science, and using a cross-discipline approach, we apply learnings from these fields to inform the design of engineering tools and practices to improve build team effectiveness
Bright white organic light-emitting diodes based on two blue emitters with similar molecular structures (2005)

We show that highly efficient and chromatically stable white organic electroluminescent devices can be obtained, based on two blue emitters with similar structures: 9,10-di-(2-naphthyl)-anthracene (ADN) and 9,10-di-(2-naphthyl)-2-terbutyl-anthracene doped with yellow-orange emitting 5,6,11,12-tetraphenylnaphthacene (rubrene) at ultralow doping concentrations (0.01%–0.05%). The relative intensity of the blue and orange-yellow emissions could be fine-tuned by varying the doping concentrations of rubrene in the host to achieve pure white emission. The energy-transfer mechanism of ADN and rubrene with ultralow doping concentrations is discussed in terms of the long exciton diffusion distance of ADN.
DNA Vaccines against Dengue Virus Type 2 Based on Truncate Envelope Protein or Its Domain III (2011)

Two DNA vaccines were constructed encoding the ectodomain (domains I, II and III) of the DENV2 envelope protein (pE1D2) or only its domain III (pE2D2), fused to the human tissue plasminogen activator signal peptide (t-PA). The expression and secretion of recombinant proteins was confirmed in vitro in BHK cells transfected with the two plasmids, detected by immunofluorescence or immunoprecipitation of metabolically labeled gene products, using polyclonal and monoclonal antibodies against DENV2. Besides, results reveal that the ectodomain of the E protein can be efficiently expressed in vivo, in a mammalian system, without the prM protein that is hypothesized to act as a chaperonin during dengue infection. Balb/c mice were immunized with the DNA vaccines and challenged with a lethal dose of DENV2. All pE1D2-vaccinated mice survived challenge, while 45% of animals immunized with the pE2D2 died after infection. Furthermore, only 10% of pE1D2-immunized mice presented some clinical signs of infection after challenge, whereas most of animals inoculated with the pE2D2 showed effects of the disease with high morbidity degrees. Levels of neutralizing antibodies were significantly higher in pE1D2-vaccinated mice than in pE2D2-immunized animals, also suggesting that the pE1D2 vaccine was more protective than the pE2D2.
Effect of sediment and aquatic ecosystem on fisheries of Mithilanchal (2015)

Sediments play on important role in maintaining the productivity of water body, has ability to store the nutrients and release them into water through different mechanisms under different conditions and maintain aquatic ecosystem. The elevate level of sodimentation and turbidity can reduce the productivity of aquatic system both these correlated factors have the potential to decrease primary productivity that may have consequence to secondary productivity and the energy low to higher topic levels. Guidelines that rely on the volumetric determination of "settleable solids" are not endorsed or use because of the difficulty of obtaining a meaningful and generally applicable relationship between this variable and suspended solids Guidelines that rely on gravimetric determination of suspended sediments concentration are recommended for use over those that rely solely on turbidity. However if the relationship is known between these variables, then turbidity may be used as a surrogate or suspended sediment. The use of guidelines that incorporate the duration of exposure to sediments provide useful analytical information or predictive purposes but caution is warranted when attempting to predict the effects of low (d" tens of mgl") levels of sediment over protected period of time. It is concluded that elevated levels of sediment may be harmful to fish and in addition negatively impact on their habitat.
Liquid-filled electrostatic generator (1966)

In initial experiments on a liquid-filled generator, voltages up to 70 kV have been realised. The liquid dielectric is pumped around a closed-loop system and acts both as a charge-transporting medium and an insulator. The charge is injected into the liquid from field-emitting electrodes.