gebhart/patrepeval huggingface dataset:
Adsorption of Serum Lipoproteins from Rainbow Trout to Dextran Sulfate Cellulose (1996)

The characteristics of serum lipoproteins from rainbow trout were investigated using dextran sulfate cellulose (DSC) gel. The binding profiles of very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL), and vitellogenin (VTG) to DSC gel were consistent with a simple Langmuir'sadsorption isotherm. The dissociation constants of VTG and VLDL were lower than those of LDL and HDL, suggesting high affinities of VTG and VLDL for DSC gel. VTG and VLDL were found to have specific capacities for binding to DSC gel from the values of maximum binding level. When applied to a DSC column, both unbound and bound fractions were present in VLDL and LDL. Apolipoprotein components differed in unbound and bound fractions, and apolipoprotein B-like protein of molecular weight 260, 000 (Mr 260K) in both VLDL and LDL seemed to have a high affinity for DSC gel. Taking into account that VTG which possessed apolipoprotein with Mr170K as a main component had the highest binding capacity to DSC gel, a structural similarity was strongly suggested between apolipoprotein B-like protein in VLDL and LDL and apolipoprotein in VTG.
Zwitterionic-Type Molten Salt: A Mild and Efficient Organocatalyst for the Synthesis of 3-Aminoalkylated Indoles via Three-Component Coupling Reaction (2011)

A general and efficient method has been developed for the synthesis of 3-aminoalkylated indoles by a three-component coupling of indoles, aldehydes, and amines in the presence of a catalytic amount of zwitterionic-type molten salt under solvent-free conditions. The non-hazardous experimental procedure, mild reaction conditions, and the reusability of the catalyst are the notable advantages of the present method.
Adult Reading Practices for Work and Leisure (1984)

Apparent reading deficiencies among entering workers, combined with increasing demands for highly skilled workers, have led business and industry to increase their training and education efforts. One aspect of this effort requires understanding the reading demands people in various occupations are likely to encounter. Using case studies and structured interviews, this study examines the reading practices of 99 adults across various occupational categories. Individual reading practices were characterized in terms of contents, materials, and uses for reading. Analyses of variance were conducted to examine the reading practices of those in different occupations and settings. It was found that reading volume for specific contents, materials, and uses were each significantly influenced by the occupational categories and settings in which reading occurred. The educational importance of accounting for this diversity in reading is discussed.
RAPID (1998)

article Free Access Share on RAPID: a free, portable GUI design tool Authors: Martin C. Carlisle Department of Computer Science, 2354 Fairchild Dr., Suite 6K41, US Air Force Academy, CO Department of Computer Science, 2354 Fairchild Dr., Suite 6K41, US Air Force Academy, COView Profile , Patrick Maes Department of Computer Science, 2354 Fairchild Dr., Suite 6K41, US Air Force Academy, CO Department of Computer Science, 2354 Fairchild Dr., Suite 6K41, US Air Force Academy, COView Profile Authors Info & Claims ACM SIGAda Ada LettersVolume XVIIIIssue 6Nov./Dec. 1998 pp 158–164https://doi.org/10.1145/301687.289570Published:01 November 1998Publication History 8citation538DownloadsMetricsTotal Citations8Total Downloads538Last 12 Months32Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Identification of a specific receptor for plasmin on a group A streptococcus (1987)

Certain group A streptococci demonstrate surface receptors that bind selectively to the key fibrinolytic enzyme, plasmin. These bacteria show no reactivity with the zymogen protein plasminogen or with other serine class proteases, such as trypsin or urokinase. Bacterium-bound plasmin retains its ability to cleave synthetic substrates and its ability to hydrolyze a fibrin clot. The bacterium-bound plasmin is not effectively regulated by its physiological regulator, alpha 2-plasmin inhibitor. This study is the first report of a bacterium-associated receptor for plasmin.
Antifungal Agents. 11.<i>N</i>-Substituted Derivatives of 1-[(Aryl)(4-aryl-1<i>H</i>-pyrrol-3-yl)methyl]-1<i>H</i>-imidazole:  Synthesis, Anti-<i>Candida</i>Activity, and QSAR Studies (2005)

1-[(Aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazoles were recently reported by our group as potent anti-Candida agents belonging to the antifungal azole class. In the present paper the synthesis, anti-Candida activities, and QSAR studies on a novel series of N-substituted 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole derivatives are reported. The newly synthesized azoles were tested against 12 strains of Candida albicans together with bifonazole, miconazole, itraconazole, fluconazole, and compounds 1a, 1b, 3a, 3b, and 3c used as reference drugs. In general, tested derivatives showed good antifungal activities, and the most potent compound was 1d (MIC(90) = 0.032 microg/mL), which was from 4- to 250-fold more potent than reference drugs. Catalyst software was applied to develop a quantitative pharmacophore model to be used for the rational design of new antifungal azoles. Some key interactions, as well as excluded volumes, further to the coordination bond of azole antifungals with the demethylase enzyme, are highlighted.
C-V2X Based Basic Safety Related ITS Spectrum Requirement Analysis (2017)

The theoretical analysis of C-V2X based basic safety related ITS spectrum needs is presented. The spectrum needs are calculated by two methodologies: traffic load mapping and queuing theory. The assumptions for transport traffic modelling were based on China transport status. According to the calculation results, at least 20MHz should be allocated to support V2V/VI basic safety application and total 30MHz should be allocated for V2V/V2I/V2P. Based on the technical study, China government allocated 20MHz for LTE-V2X trial in the end of 2016, which is mainly for V2V/V2I. The methodologies presented in this paper, enables the spectrum requirement for other regions and countries to be evaluated with the adjusted assumptions.
C-slow Technique vs. Multiprocessor in designing low Area Customized Instruction set Processor for Embedded Applications (2011)

The demand for high performance embedded processors, for consumer electronics, is rapidly increasing for the past few years. Many of these embedded processors depend upon custom built Instruction Ser Architecture (ISA) such as game processor (GPU), multimedia processors, DSP processors etc. Primary requirement for consumer electronic industry is low cost with high performance and low power consumption. A lot of research has been evolved to enhance the performance of embedded processors through parallel computing. But some of them focus superscalar processors i.e. single processors with more resources like Instruction Level Parallelism (ILP) which includes Very Long Instruction Word (VLIW) architecture, custom instruction set extensible processor architecture and others require more number of processing units on a single chip like Thread Level Parallelism (TLP) that includes Simultaneous Multithreading (SMT), Chip Multithreading (CMT) and Chip Multiprocessing (CMP). In this paper, we present a new technique, named C-slow, to enhance performance for embedded processors for consumer electronics by exploiting multithreading technique in single core processors. Without resulting into the complexity of micro controlling with Real Time Operating system (RTOS), C-slowed processor can execute multiple threads in parallel using single datapath of Instruction Set processing element. This technique takes low area & approach complexity of general purpose processor running RTOS.
Two-dimensional ultrashallow junction characterization of metal-oxide-semiconductor field effect transistors with strained silicon (2004)

Strained Si has been realized as one of the most promising candidates of next generation complementary metal-oxide-semiconductor technology. Since the carrier mobility can be significantly increased with strained Si lattice, the device speed can be further increased without reducing the critical dimensions. However, ultrashallow junction engineering becomes more challenging due to much complicated dopant diffusion behavior. We have used scanning capacitance microscopy and dopant selective etching to characterize such differences by comparing the devices fabricated with strained Si channel and with conventional unstrained Si. The devices we used are p-type channel complementary metal-oxide-semiconductor field effect transistors fabricated with 130 nm technology, with strained Si channel built on SiGe pseudosubstrate. Significant differences were observed in the formation of source/drain (S/D) extensions. The junction profile shows abrupt transition from S/D extension to S/D comparing with unstrained Si. Meanwhile, halo implant was much suppressed. These differences can be explained with retarded B diffusion and enhanced As diffusion in tensile strained Si and relaxed SiGe lattices, which is consistent with the calculation using lattice expansion theory.
Does tortuosity in cerebral arterioles impair down-autoregulation in hypertensives and elderly normotensives? A hypothesis and computer model. (1991)

A mathematical model of pressure/flow relationships in straight and tortuous intracerebral arterioles is presented. Using this model, it is predicted that patients with severe tortuosity would never be able to tolerate an appreciable decrease in MAP. This morphological alteration may explain the inability of a few hypertensive and normotensive elderly patients to tolerate periods of mild reductions in blood pressure. The alkaline phosphatase histochemical staining technique is potentially an excellent method of establishing the identity of deep white matter signal alterations seen on MRI because of its ability to trace the vascular supply from the brain surface to the lesion.
Nβ-Fmoc-Nβ-Methyl-aza-β³-amino Acids (2011)

The potential of peptides as drug candidates is limited by their poor pharmacokinetic properties. Many peptides have a short half-life, in vivo half-life, and insufficient oral availability. Inspired by the N-methylation of peptides as a promising way to rationally improve key pharmacokinetic characteristics, we report our efforts toward an easy synthesis of new monomers N β-Fmoc-N β-Me-aza-β³-amino acids. These synthetic building blocks will be useful for solid-phase synthesis of new peptidomimetics.
A new technique for transmission of pre-encoded MPEG VBR video using CBR service (2002)

This paper presents the system issues involved with the transmission of pre-encoded variable bit rate (VBR) MPEG video using the constant bit rate (CBR) service. Conventional wisdom suggests that lossless delivery of VBR video using the CBR service requires bandwidth to be reserved at the peak rate resulting in low bandwidth utilization. We calculate the minimum rate at which bandwidth must be reserved on a network in order to provide continuous playback of an MPEG encoded video bitstream. Simulation results using the frame size traces from several pre-encoded MPEG bitstreams and several buffer sizes demonstrate that this "minimum reservation rate" is much lower than the peak rate when a modest playback buffer size is used, resulting in much higher bandwidth utilization. Procedures for performing connection setup and lossless realtime video playback between the video server and the client are outlined. Methods for incorporating VCR-like features such as "pause" and "fast forward/reverse" for video-on-demand (VoD) applications are presented.
Isolation and characterization of human immunodeficiency virus type 1 variants infectious to brain-derived cells: detection of common point mutations in the V3 region of the env gene of the variants (1994)

T-cell-line-tropic human immunodeficiency virus type 1 cannot infect CD4-positive, brain-derived cells. We isolated several new variants that readily infected brain-derived cells. Mutation of proline to serine, to alanine, or to threonine in the well-conserved GPGR sequence in the V3 region of the envelope glycoprotein was found in all these variants. This indicates the importance of amino acid sequences at the tip of the V3 region for brain cell tropism of human immunodeficiency virus type 1.
Learning Global Additive Explanations for Neural Nets Using Model Distillation (2018)

Interpretability has largely focused on local explanations, i.e. explaining why a model made a particular prediction for a sample. These explanations are appealing due to their simplicity and local fidelity. However, they do not provide information about the general behavior of the model. We propose to leverage model distillation to learn global additive explanations that describe the relationship between input features and model predictions. These global explanations take the form of feature shapes, which are more expressive than feature attributions. Through careful experimentation, we show qualitatively and quantitatively that global additive explanations are able to describe model behavior and yield insights about models such as neural nets. A visualization of our approach applied to a neural net as it is trained is available at this https URL.
Cell culture compared with broth for detection of Trichomonas vaginalis (1987)

Trichomonas vaginalis can be grown in cell culture. We studied the growth kinetics of T. vaginalis in McCoy cell culture compared with that in a conventional broth medium (Diamond TYI-S-33 medium supplemented with 10% heat-inactivated bovine serum [TYI]). In the presence of McCoy cells and two parts cell culture medium to one part TYI, a peak concentration of 2 X 10(6) to 6 X 10(6) T. vaginalis per ml was consistently achieved with inocula as low as three T. vaginalis cells per ml. Without cells, this medium did not support growth of T. vaginalis. T. vaginalis in TYI in 1-ml vials with or without McCoy cells demonstrated poor growth. In tubes containing 10 ml of TYI, inocula grew to 2 X 10(6) to 6 X 10(6) T. vaginalis per ml, but at least 3 X 10(3) T. vaginalis per tube was required to initiate growth. Thus, in vitro, cell culture was more sensitive than TYI broth in detecting low numbers of T. vaginalis. In a subsequent clinical comparison of broth and cell culture for isolation of T. vaginalis from 188 vaginal specimens and 21 urethral specimens from men, the results were in agreement for 206 specimens (98.6%). There were no situations in which culture was negative and a saline preparation showed motile trichomonads. For women, using a positive culture as the indicator of true positivity, the sensitivity of detection of T. vaginalis was 83% with the Pappenheim stain and 77% with saline preparations. These studies show that cell culture can be used for isolation of T. vaginalis from clinical specimens; it gave results comparable to those of broth culture for the group of mainly symptomatic women. Further studies should be performed to determine its utility in clinical populations such as asymptomatic women and men with and without symptoms, in which T. vaginalis is more likely to be present in low numbers.
A point process approach to assess the frequency dependence of ultrasound backscattering by aggregating red blood cells (2001)

To study the shear-thinning rheological behavior of blood, an acoustical measurement of the erythrocyte aggregation level can be obtained by analyzing the frequency dependence of ultrasonic backscattering from blood. However, the relation that exists among the variables describing the aggregation level and the backscattering coefficient needs to be better clarified. To achieve this purpose, a three-dimensional random model, the Neyman–Scott point process, is proposed to simulate red cell clustering in aggregative conditions at a low hematocrit (H&lt;5%). The frequency dependence of the backscattering coefficient of blood, in non-Rayleigh conditions, is analytically derived from the model, as a function of the size distribution of the aggregates and of their mass fractal dimension. Quantitative predictions of the backscatter increase due to red cell aggregation are given. The parametric model of backscatter enables two descriptive indices of red cell aggregation to be extracted from experimental data, the packing factor W and the size factor Δ. Previously published backscatter measurements from porcine whole blood at 4.5% hematocrit, in the frequency range of 3.5 MHz–12.5 MHz, are used to study the shear-rate dependence of these two indices.
Association of peroxisome proliferator-activated receptor and Hsp72. (1994)

In an effort to understand the relationship between a 72-kDa heat shock protein (Hsp72) and peroxisome proliferator-activated receptors (PPARs), we have characterized their interaction using clofibric acid-Sepharose chromatography and co-immunoprecipitation with antisera raised against either rat PPAR (rPPAR) or Hsp72. First, we observed that both rPPAR and Hsp72 elute in a clofibrate-dependent manner from the clofibric acid-Sepharose matrix. Second, we found that immunoprecipitation of either protein from solution resulted in the precipitation of the other. This result was obtained from rat liver cytosol, from Spodoptera frugiperda (Sf9) insect cells expressing rPPAR, and from reticulocyte lysate rPPAR expression systems. These results suggest that Hsp72 and rPPAR form a complex in vivo and that Hsp72 may play a role in the folding, subcellular localization, and/or signaling pathway of PPARs.
Targeting Rac1 by the Yersinia Effector Protein YopE Inhibits Caspase-1-mediated Maturation and Release of Interleukin-1β (2004)

Yersinia bacteria can take control of the host cell by injecting so-called Yop effector proteins into the cytosol of the cells to which they adhere. Using Yersinia enterocolitica strains that are deficient for one or more Yops, we could show that YopE and, to a lesser extent, YopT interfere with the caspase-1-mediated maturation of prointerleukin-1beta in macrophages. In addition, overexpression of YopE and YopT was shown to prevent the autoproteolytic activation of caspase-1 in a way that is dependent on their inhibitory effect on Rho GTPases. Expression of constitutive-active or dominant-negative Rho GTPase mutants or treatment with Rho GTPase inhibitors confirmed the role of Rho GTPases and, in particular, Rac1 in the autoactivation of caspase-1. Rac1-induced caspase-1 activation was mediated by its effect on LIM kinase-1, which is targeting the actin cytoskeleton. Rac-1 and LIM kinase-1 dominant-negative mutants were shown to inhibit caspase-1 activation induced by overexpression of Asc, which is a caspase-1-activating adaptor protein. Moreover, Rac1 as well as YopE and YopT significantly modulated caspase-1 oligomerization. These results highlight a previously unknown function of Rho GTPases in the activation of caspase-1 and give new insight on the role of YopE in immune-escape mechanisms of Yersinia.
Enabling database-aware storage with OSD (2007)

The ANSI object-based storage device (OSD) standard is a major step toward enabling explicit application-awareness in storage systems behind a standard, fully- interoperable interface [3]. In this paper, we explore a particular flavor of application-awareness, that of database applications. We describe the design and implementation of a database-aware storage system that uses the OSD interface not only as a means to access data, but also to permit explicit communication between the application and the storage system. This communication is significant, as it enables our storage system to transparently optimize data placement and request scheduling. We demonstrate that OSD makes it practical to improve storage performance in these ways without exposing proprietary disk drive parameters to application code, and without labor-intensive, fragile parameter measurement.
Isolation of the nonhistone proteins of rat Walker carcinoma 256. Their association with tumor angiogenesis (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of the nonhistone proteins of rat Walker carcinoma 256. Their association with tumor angiogenesisDorothy Tuan, Sandra Smith, Judah Folkman, and Enzio MerlerCite this: Biochemistry 1973, 12, 17, 3159–3165Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://pubs.acs.org/doi/10.1021/bi00741a004https://doi.org/10.1021/bi00741a004research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
All-optical logic gates based on nonlinear dielectric films (2008)

We analyze interaction of two nonlinear waves in thin amorphous dielectric film with reflecting edges. All-optical logic gates "AND", "OR" and "XOR", which are based on the dielectric film and involve no semiconductor components, are simulated both analytically and numerically.
Control Components Using Si, GaAs, and GaN Technologies (2014)

Control circuits are important parts of RF and microwave systems. Their compact size, high performance, and low cost have played a vital role in the development of cost effective solutions and new applications during the past quarter century. This book provides a comprehensive treatment of such circuits, including device operation and their models, basic circuit theory and designs, and applications. The unique features of this book include in-depth and comprehensive study of control circuits, extensive design equations and figures, treatment of practical aspect of circuits and description of fabrication technologies. It provides you with a broad view of solid state control circuits including various technologies and their comparison and up to date information.