gebhart/patrepeval huggingface dataset:
Demetalation of Tricarbonyl(cyclopentadienone)iron Complexes Initiated by a Ligand Exchange Reaction with NaOH—X-Ray Analysis of a Complex with Nearly Square-Planar Coordinated Sodium (1999)

A sequential exchange of one carbonyl ligand by a hydrido ligand with NaOH, and then by an iodo ligand with iodopentane and finally treatment with acid transforms tricarbonyl(η<sup>4</sup>-cyclopentadienone)iron complexes into dicarbonyl(η<sup>5</sup>-hydroxycyclopentadienyl)iodoiron complexes. These iodo complexes demetalate with high selectivity to the corresponding free ligands on contact with air in daylight. Under basic reaction conditions at the stage of the iodo complex an anionic dicarbonyl(η<sup>4</sup>-cyclopentadienone)iodoiron complex is generated, which is dimeric in the solid state and has an almost square-planar arrangement of the ligands at the sodium counterion.
Pilot study on the effectiveness of the conventional CROS, the transcranial CROS and the BAHA transcranial CROS in adults with unilateral inner ear deafness (2009)

The objective of the present pilot study is to evaluate the effectiveness of three conventional contralateral routing of sound (CROS) hearing aids in adults with unilateral inner ear deafness. The study included tertiary referral center. Ten patients with unilateral inner ear deafness and normal hearing in the contralateral ear were selected to evaluate three different methods of amplification: the CROS hearing aid, the completely in the canal hearing aid and the bone-anchored hearing aid CROS (BAHA). Each of the three hearing aids was tried in a random order for a period of 8 weeks. Audiometric performance, including speech-in-noise, directional hearing and subjective benefit were measured after each trial period, using the APHAB, SSQ and single-sided deafness questionnaire. Sound localization performance was essentially at chance level in all four conditions. Mixed results were seen on the other patient outcome measures that alternated in favor of one of the three CROS devices. After the trial, three patients chose to be fitted with the BAHA CROS and one with the conventional CROS. In conclusion, most of the patients experienced some degree of benefit with each of the three hearing aids. Preference for one of the three hearing aids was independent of the order in which they were tried. It would be worthwhile to formulate selection criteria; still, we recommend that all patients with unilateral inner ear deafness should be offered a trial with at least the BAHA CROS.
Laser Welding of Alumina Ceramic Substrates with Two Fixed Beams (2013)

Thesis (Master, Mechanical and Materials Engineering) -- Queen's University, 2013-04-29 17:59:57.43
A cool packaging technology for power conversion application (2011)

Power management relieves critical bottlenecks in saving electrical energy and efficient switching devices are particularly required for synchronous power conversion module. To optimize both switching and thermal efficiencies for convertor configuration it relies on the advanced package technology. An analysis has been undertaken in this work to identify the challenge on power electronic packages to ensure the system efficiencies continue to increase. This paper presents an innovative three-dimension (3D) packaging technology - CoolPAK, which enables high voltage, high frequency and high reliable voltage switching with reduced power loss in thermal dissipation.
Time Series Prediction with Variational Bayesian Nonlinear State-Space Models (2007)

Abstract. In this paper the variational Bayesian method for learning nonlinear state-space models introduced by Valpola and Karhunen in 2002 is applied to prediction in the ESTSP’07 time series prediction competition data set. The data set is pre-processed by approximately removing the periodic component of the data and the nonlinear state-space model is only learned on the residuals. The model uses multilayer perceptron (MLP) networks to model the nonlinearities of the system which allows the modelling of complex dynamical processes. The variational Bayesian learning approach is resistant to overfitting and allows comparison of different model structures using the derived lower bound on marginal log-likelihood. The desired predictions are evaluated as the mean of a Monte Carlo approximation of the predictive distribution. 1
Enhancement of Apoptotic Susceptibility in Human Endometrial Epithelial Cell Line HHUA by Transforming Growth Factor-β1 (1998)

Although reports have been published on the generation of transforming growth factor-beta 1 (TGF-beta 1) and expression of TGF-beta receptors in human endometrial tissues, the biological functions of endometrial TGF-beta 1 have remained unclear. In this study, the effects of TGF-beta 1 on endometrial apoptosis were examined by using an endometrial epithelial cell line HHUA which is susceptible to Fas-mediated apoptosis. TGF-beta 1 alone did not affect the cell growth of HHUA, but pretreatment of HHUA with TGF-beta 1 enhanced Fas-mediated growth suppression and DNA fragmentation of the cells. Flow cytometric analyses showed that TGF-beta 1 did not affect Fas expression on the cell surface. These findings lead to the conclusion that TGF-beta 1 enhances susceptibility to Fas-mediated apoptosis in the endometrial epithelial cell. Modulation of Fas-mediated endometrial apoptosis by TGF-beta 1 may thus be a tissue-specific effect which is distinct from other TGF-beta 1 effects on Fas-mediated apoptosis in activated T-cells and rheumatoid synovial cells. The biological functions of endometrial TGF-beta 1 and endometrial apoptosis are also discussed.
Preparation of calcium phosphate cement with an improved setting behavior (2013)

In the aim of the development of a calcium phosphate cement (CPC) that allows a sufficiently long kneading time at room temperature while sets promptly at a physiological temperature, the powder components of a CPC of a TeTCP–α-TCP–DCPD system were coated with gelatin. The gelatin coating on TeTCP or DCPD-containing portion effectively retarded the setting reaction at 293 K while it did not hinder at 310 K, implying the possibility of CPC with an improved setting behavior. Compressive strength of 41 MPa was attained for a gelatin-coated CPC.
A transient-kinetic study of the nitrogenase of <i>Klebsiella pneumoniae</i> by stopped-flow calorimetry. Comparison with the myosin ATPase (1989)

The pre-steady-state kinetics of MgATP hydrolysis by nitrogenase from Klebsiella pneumoniae were studied by stopped-flow calorimetry at 6 degrees C and at pH 7.0. An endothermic reaction (delta Hobs. = +36 kJ.mol of ATP-1; kobs. = 9.4 s-1) in which 0.5 proton.mol of ATP-1 was released, has been assigned to the on-enzyme cleavage of MgATP to yield bound MgADP + Pi. The assignment is based on the similarity of these parameters to those of the corresponding reaction that occurs with rabbit muscle myosin subfragment-1 (delta Hobs. = +32 kJ.mol of ATP-1; kobs. = 7.1 s-1; 0.2 proton released.mol of ATP-1) [Millar, Howarth & Gutfreund (1987) Biochem. J. 248, 683-690]. MgATP-dependent electron transfer from the nitrogenase Fe-protein to the MoFe-protein was monitored by stopped-flow spectrophotometry at 430 nm and occurred with kobs. value of 3.0 s-1 at 6 degrees C. Thus, under these conditions, hydrolysis of MgATP precedes electron transfer within the protein complex. Evidence is presented that suggests that MgATP cleavage and subsequent electron transfer are reversible at 6 degrees C with an overall equilibrium constant close to unity, but that, at 23 degrees C, the reactions are essentially irreversible, with an overall equilibrium constant greater than or equal to 10.
Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis (2011)

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death, reflecting the need for better understanding the oncogenesis, and developing new diagnostic and therapeutic targets for the malignancy. Emerging evidence suggests that small nucleolar RNAs (snoRNAs) have malfunctioning roles in tumorigenesis. Our recent study demonstrated that small nucleolar RNA 42 (SNORA42) was overexpressed in lung tumors. Here, we investigate the role of SNORA42 in tumorigenesis of NSCLC. We simultaneously assess genomic dosages and expression levels of SNORA42 and its host gene, KIAA0907, in 10 NSCLC cell lines and a human bronchial epithelial cell line. We then determine in vitro functional significance of SNORA42 in lung cancer cell lines through gain- and loss-of-function analyses. We also inoculate cancer cells with SNORA42-siRNA into mice through either tail vein or subcutaneous injection. We finally evaluate expression level of SNORA42 on frozen surgically resected lung tumor tissues of 64 patients with stage I NSCLC by using quantitative reverse transcriptase PCR assay. Genomic amplification and associated high expression of SNORA42 rather than KIAA0907 are frequently observed in lung cancer cells, suggesting that SNORA42 overexpression is activated by its genomic amplification. SNORA42 knockdown in NSCLC cells inhibits in vitro and in vivo tumorigenicity, whereas enforced SNORA42 expression in bronchial epitheliums increases cell growth and colony formation. Such pleiotropy of SNORA42 suppression could be achieved at least partially through increased apoptosis of NSCLC cells in a p53-dependent manner. SNORA42 expression in lung tumor tissue specimens is inversely correlated with survival of NSCLC patients. Therefore, SNORA42 activation could have an oncogenic role in lung tumorigenesis and provide potential diagnostic and therapeutic targets for the malignancy.
Effect of Positive Angular Velocity Feedback on Torque Control of Hydraulic Actuator. (1992)

Output torque/force of a hydraulic actuator is generally affected by its driving speed. This may cause deterioration of the control accuracy of the system in which the plant is controlled through the driving torque/force control of the actuator. This study proposes a positive angular velocity feedback for compensation of the effect of the driving speed on the driving torque control of a rotary hydraulic actuator. The compensation scheme is experimentally applied to motion control of a one-link hydraulic robot which is controlled by means of the computed torque method. The experiments show that the compensation scheme is effective in isolating the driving torque of the actuator from its driving speed and slightly improves the tracking accuracy of the motion control.
Spatial voting for automatic feature selection, fusion, and visualization (2013)

We present a novel feature selection, fusion, and visualization utility using Spatial Voting (SV). This SV feature optimization utility is designed to be an off-line stand-alone utility to help an investigator find useful feature pairs for cluster analysis and lineage identification. The analysis can be used to enable the analyst to vary parameters manually and explore the best combination that yields visually appealing or significant groups or spreading of data points depending on the planned use of the analysis downstream. Several different criteria are available to the user in order to determine the best SV grid size and feature pair including minimizing zeros, minimizing covariance, balanced minimum covariance, or the maximization of one of eight different scoring metrics: Containment, Rand Index, Purity, Precision, Recall, F-Score, Normalized Mutual Information (NMI), and Adjusted Rand Index (ARI). The tool that is described in this work facilitates this analysis and makes it simple, efficient, and interactive if the analyst so desires.
The Human Genome Project: Past, Present, and Future (1990)

This article presents a short discussion of the development of the human genome program in the United States, a summary of the current status of the organization and administration of the National Institutes of Health component of the program, and some prospects for the future directions of the program and the applications of genome information.
Comparison of experimental and theoretical persistence length of some polyelectrolytes at various ionic strengths (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of experimental and theoretical persistence length of some polyelectrolytes at various ionic strengthsMichel TricotCite this: Macromolecules 1984, 17, 9, 1698–1704Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ma00139a010https://doi.org/10.1021/ma00139a010research-articleACS PublicationsRequest reuse permissionsArticle Views886Altmetric-Citations160LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Broth microdilution methods using B-lactamase inhibitors for the identification of Klebsiella pneumoniae carbapenemases and metallo-β-lactamases in Gram-negative bacilli. (2014)

This study was designed to evaluate the performance of the broth microdilution (BMD) test in detecting the production of Klebsiella pneumoniae carbapenemases (KPCs) and metallo-β-lactamases (MBLs) in clinical isolates of gram-negative bacilli by using various β-lactamase inhibitors. A carbapenemase detection test, comprised of Mueller-Hinton broth containing serial twofold dilutions of imipenem or meropenem with and without aminophenylboronic acid (APB), phenylboronic acid (PB), cloxacillin (CLX), dipicolinic acid (DPA), or EDTA, was evaluated against 31 Klebsiella pneumoniae strains with KPC, 21 MBL-producers (3 Enterobacteriaceae and 18 non-fermenters), and 26 carbapenemase-non-producing Enterobacteriaceae strains. A threefold or greater decrease in the MIC of imipenem or meropenem with β-lactamase inhibitors, when compared with the imipenem or meropenem alone, was considered a positive result. Imipenem with and without PB had the most comparable sensitivity (93.5%) and specificity (93.6%) for the detection of K. pneumoniae with KPC enzymes if the additional criterion of a negative CLX result was included. Both DPA and EDTA had excellent sensitivity (imipenem with and without DPA vs. EDTA, 90.5% vs. 95.2%) and specificity (imipenem with and without DPA vs. EDTA, 98.2% vs. 100%) for the detection of MBL-producing gram-negative bacilli. The comparative study showed that, by using imipenem with and without PB, CLX, and EDTA, the BMD test was effective in detecting KPC and MBL enzymes. The BMD test could be applied for routine use in commercially available semiautomated systems for the detection of KPCs and MBLs in gram-negative bacilli.
The Expulsion of Mexico's Spaniards, 1821-1836. (1992)

Drawing on manuscript records in the Mexican national archives. Harold Sims provides an account of the expulsion laws passed in 1827-29 and 1833-34 and the chaos they caused in the new Mexican republic. Mexico's colonial experience had left a bitter legacy. Many believed that only the physical removal of the old colonial elite could prevent the consolidation of a new economic and political oligarchy in the republic. While expulsion seemed to provide an answer, the expulsion decrees met stiff resistance and caused a tug-of-war between enforcement and evasion that went on for years. The issue embroiled national and local governments in partisan battle. Friendship, family influence, intrigue and bribery all played a role in determining who left and who stayed. Because exemptions were granted for illness, a thriving business emerged among corrupt physicians. The expulsion issue also fueled rebellions, with anti-Spanish feeling often the proncipal motive for insurgency. After years of struggle, the movement died down. but not until three-quarters of Mexico's peninsulars had been forces to leave. Expulsion crippled a once flourishing economy by spurring massive capital flight. Spaniards were virtually eliminated from the military, the bureaucracy, the mining industry and the Church; they survived only in commerce. The primary victim was republican government itself in 1834, conservatives sought to halt social upheaval by installing a dictatorship. This study analyzes the strength of the Spanish community in the 1820s and 1830s and examines the ramifications of the hostile reaction caused by Mexico's former domination by Spain.
Reductive One Batch Synthesis of N-Substituted Pyrrolidines from Primary Amines and 2,5-Dimethoxytetrahydrofuran (1999)

The construction of the pyrrolidine ring about a nitrogen of a primary amine by a reductive condensation reaction using 2,5-dimethoxytetrahydrofuran and sodium borohydride in acidic water medium is described. The reaction is fast, affords good to excellent yields and appears insensitive to electron effects and severe steric hindrance; it is found to be compatible with a large variety of aryl substituents, including nitro and oxo groups. The reaction allows the introduction of two deuterium atoms, with label conservation, in both the alpha-positions of the pyrrolidine ring by the use of sodium borodeuteride instead of sodium borohydride.
Radar and conventional occupancy sensors performance comparison (2014)

Doppler Radar sensor is designed for occupancy detection application and tested in conjunction with common occupancy sensors such as passive infrared and ultrasonic to determine the optimal design for a robust and power efficient occupancy sensor. A 2.4 GHz CW radar is employed for the microwave presence detection. Sensors have been tested for different scenarios like hand waving, writing, and mechanical targets at directions perpendicular and parallel to the sensors. Results showed that infrared and ultrasonic both have limitations with sensing through materials and direction of movement. Doppler radar was shown to be superior, but must be integrated with other sensors to create a power efficient occupancy sensor.
Nanocrystalline Chalcopyrite Materials (CuInS<sub>2</sub>and CuInSe<sub>2</sub>) via Low-Temperature Pyrolysis of Molecular Single-Source Precursors (2003)

Nanometer-sized particles of the chalcopyrite compounds CuInS2 and CuInSe2 were synthesized by thermal decomposition of molecular single-source precursors (PPh3)2CuIn(SEt)4 and (PPh3)2CuIn(SePh)4, respectively, in the noncoordinating solvent dioctyl phthalate at temperatures between 200 and 300 °C. The nanoparticles range in size from 3 to 30 nm and are aggregated to form roughly spherical clusters of about 500 nm in diameter. X-ray diffraction of the nanoparticle powders shows greatly broadened lines, indicative of very small particle sizes, which is confirmed by TEM. Peaks present in the XRD can be indexed to reference patterns for the respective chalcopyrite compounds. Optical spectroscopy and elemental analysis by energy dispersive spectroscopy support the identification of the nanoparticles as chalcopyrites.
Sequential Projective Measurements for Channel Decoding (2011)

We study the transmission of classical information in quantum channels. We present a decoding procedure that is very simple but still achieves the channel capacity. It is used to give an alternative straightforward proof that the classical capacity is given by the regularized Holevo bound. This procedure uses only projective measurements and is based on successive "yes-no" tests only.
Pulsatile Versus Continuous Intravenous Administration of Growth Hormone (GH) in GH-Deficient Patients: Effects on Circulating Insulin-Like Growth Factor-I and Metabolic Indices (1990)

The episodic and pulsatile nature of GH secretion in normal man is well established. Studies in hypophysectomized rats have indicated that pulsatile administration of GH is superior to continuous infusion in promoting growth, but similar studies have not yet been conducted in human subjects. We compared three different iv GH administration schedules in six GH-deficient patients. They were hospitalized three times for 44 h on three occasions, separated by at least 4 weeks without GH treatment. On each occasion they received 2 IU GH, administered iv as either 1) two boluses (at 2000 and 0200 h), 2) eight boluses (at 3-h intervals starting at 2000 h), or 3) a continuous (2000-0200 h) infusion. Serum insulin-like growth factor-I (IGF-I) after eight boluses and that after continuous infusion were almost identical, with a steep increase reaching a peak at 2000-2400 h, followed by a steady decline. The total areas under the curve, expressed as mean levels (micrograms per L), were 147.6 +/- 11.8 (eight boluses) and 151.2 +/- 8.9 (infusion; P = NS). The change with time in IGF-I after the two-bolus regimen differed significantly from that in the other studies (P less than 0.001), displaying only a modest increase, as also reflected in a smaller area under the curve of serum IGF-I (125.3 +/- 8.7 micrograms/L; P less than 0.05). No differences in blood glucose, serum insulin, or plasma glucagon were observed when comparing the three studies. Both blood glucose and serum insulin tended to be elevated during the second night of each study. Almost identical fluctuations were recorded in lipid intermediates in the three studies, with nightly elevations being more pronounced on the first night. Alanine and lactate exhibited nearly identical patterns in the three studies and were characterized by low nocturnal levels. These data indicate that small but frequent iv boluses and continuous infusion of GH are equally effective in generating an increase in IGF-I in GH-deficient patients, whereas the same amount of GH given as two large boluses results in a significantly smaller increase in IGF-I. This could mean that a prolongation of the period during which serum GH is above zero in GH-treated subjects is just as essential as pulsatility for the growth-promoting effects of the hormone.
Comparison of CD variation between organic and inorganic bottom antireflective coating on topographic substrates (1999)

This paper describes the CD control of using bottom anti- reflective coating (BARC) processes on topographic substrates for DUV lithography. The CD variation using organic anti-reflective coating (ARC) and inorganic anti- reflective layer (ARL) is different because of their coverage characteristics on topography. We have compared the CD variation of different BARC processes on various step widths and heights. The CD range using highly planarizing ARC was smaller than that using another less planarizing local step is advantageous to CD control on topographic substrates. We analyzed the cause of large CD variation using ARL and found that the impact of the oblique reflection from a photoresist/ARL interface at steps.
Induction by transforming growth factor-β1 of epithelial to mesenchymal transition is a rare event in vitro (2004)

The results presented herein show that, although many cancer cell lines have lost sensitivity to the growth inhibitory effect of TGF-beta1, most show evidence of TGF-beta1 signal transduction, but only a few cell lines undergo TGF-beta1-mediated EMT.