gebhart/patrepeval huggingface dataset:
Inhibition of Listeria monocytogenes growth by the lactoperoxidase-thiocyanate-H2O2 antimicrobial system (1989)

The lactoperoxidase-thiocyanate-H2O2 system (LP system), consisting of lactoperoxidase (0.37 U/ml), KSCN (0.3 mM), and H2O2 (0.3 mM), delayed but did not prevent growth of L. monocytogenes Scott A at 5, 10, 20, and 30 degrees C in broth and at 20 degrees C in milk. The net lag periods determined spectrophotometrically varied inversely with temperature and were shorter at 5 and 10 degrees C for cultures from shaken versus from statically grown inocula. Lag periods for cultures from shaken and statically grown inocula, respectively, were 73 and 98 h at 5 degrees C, 22 and 32 h at 10 degrees C, both 8.9 h at 20 degrees C, and both 2.8 h at 30 degrees C. After the lag periods, the maximum specific growth rates were similar for each of the three treatments (complete LP system, H2O2 alone, or control broth) at 5, 10, and 20 degrees C and were 0.06 to 0.08, 0.09 to 0.1, and 0.32 to 0.36/h, respectively. At 20 degrees C in sterile reconstituted skim milk, the LP system restricted growth of Scott A, with log CFU counts per ml at 0, 36, and 68 h being 5.7, 6.4 and 7.9 (versus 5.7, 9.8, and 11.2 for controls). Possible explanations for the decreased lag times observed for cultures from aerobically grown inocula are discussed.
<title>UV-laser/biotissue interactions and delivery systems</title> (1997)

The interactions of UV laser beams and biotissues have been studied. The cutting quality of an ArF laser was the best sharp for hard biotissues (e.g. a bone, a tooth). From the current experiments, we found that the KrF laser beam has the highest incision ability for biological lipid of excimer lasers. For example, suet was cut off sharply by the KrF laser beam. On the other hand, the ArF laser incision has no thermal damage on suet even for the high repetition rate and the high energy fluence. However the conventional optical quartz fiber can not be available for an excimer laser beam (far-UV). So we have been investigating about UV laser power beam delivery systems. In the case of the hollow light guide with the aluminum-phosphor bronze reflector, we have obtained 56 and 75%/m transmittance of the ArF and KrF laser in straight state, respectively. Its delivery energy was 45 and 110 mJ/pulse of the ArF and KrF laser, respectively. The ArF laser transmittance has been tried in various atmosphere such as air, nitrogen, oxygen and helium. Finally, the medium of the laser delivery of the hollow light guide had better use the helium gas instead of the air. And the ArF laser transmittance and delivery energy were obtained 71%/m and 50 mJ/pulse, respectively. We have also tried the quartz fiber with OH ion doped core. The effects of a lightly doped clad with B and F on the transmittance have been investigated. In the one pulse operation, the ArF laser transmittance of B and F doped clad fiber was obtained 82%/m, which was better than that of only F doped clad fiber. The hollow light guide is suitable for the delivery system of UV laser scalpels, and the UV fiber is the useful delivery system of UV laser endoscopes.
Amorphous, Polymorphous, and Microcrystalline Silicon Thin Films Deposited by Plasma at Low Temperatures (2016)

The present chapter is devoted to the study of amorphous (a-Si:H), polymorphous (pm-Si:H), and microcrystalline (μc-Si:H) silicon, deposited by the plasma-enhanced chemical vapor deposition (PECVD) technique at low temperatures. We have studied the main deposition parameters that have strong influence on the optical, electrical, and structural properties of the polymorphous and microcrystalline materials. Our results reveal the key deposition conditions for obtained films with optical and electrical characteristics, which are suitable for applications on thin-film solar cells and semiconductor devices.
Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid (2000)

The present results suggest that the architecture of the epidermis and the papillary dermis can be regenerated by simply injuring the cornified layer by using topical agents such as salicylic acid that do not cause degeneration or inflammation.
IRIA State-of-the-Art Report: Optical-Mechanical, Active/Passive Imaging Systems. Volume I. (1982)

This first volume of a two part report on the state-of-the-art of optical-mechanical, active/passive imaging systems presents a tutorial treatment of such systems. Included are design and characterizing parameters relating to the radiation available for imaging, the intervening atmosphere, optical and mechanical components, scanning processes, detectors, and associated electronics. The second volume presents a survey of systems developed during the 1970's.
Dissolution of uranium oxides and electrochemical behavior of U(VI) in task specific ionic liquid (2008)

A task-specific ionic liquid, protonated 1-carboxy- N , N , N -trimethylmethanaminium bis(trifluoromethylsulfonyl)imide trivially known as protonated betaine bis(trifluoromethylsulfonyl)-imide ([Hbet][NTf 2 ]) was prepared and the dissolution of uranium oxides, UO 3 , UO 2 and U 3 O 8 in it was studied. Dissolution of UO 3 in [Hbet][NTf 2 ] was very rapid and the saturation solubility of uranium was found to be 15 wt. % at 373 K. In contrast, dissolution of UO 2 was sluggish and it was facilitated only by the oxidation of UO 2 to UO 2 2+ . U 3 O 8 was insoluble up to 453 K. A new procedure was developed for the individual separation of uranium oxides using [Hbet][NTf 2 ] based on differences in solubilities. The electrochemical behavior of U(VI) in the resultant solution was investigated by cyclic voltammetry at glassy carbon working electrode at 373 K. A surge in the cathodic peak current at -0.48 V ( vs . Fc/Fc + ) was due to the reduction of U(VI) to U(V) and the corresponding anodic peak current was observed at a potential of 0.64 V. Increasing the potential sweeping rate increases the peak current and shifts the peak potential negatively indicating the irreversible electroreduction of U(VI) in [Hbet][NTf 2 ]. The diffusion coefficient of U(VI) in [Hbet][NTf 2 ] was determined to be of the order of ∼10 −8 cm 2 /s.
Jingxing： a Historic County of China (2013)

County has played an important role in the histor y of China since it was first established as a basic administrative unit in the Qin Dynasty more than 2,000 years ago.Historic counties have not only performed administrative and economic functions but also carried and preserved basic information about culture andtraditions of China.Not long ago,the
Potential Anticancer Agents. LXXVIII.<sup>1</sup> Nonclassical Antimetabolites. IV.<sup>2</sup> Synthesis of Compounds Related to 4-(Iodoacetamido)salicylic Acid, an Exo-Alkylating Irreversible Inhibitor (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential Anticancer Agents. LXXVIII.1 Nonclassical Antimetabolites. IV.2 Synthesis of Compounds Related to 4-(Iodoacetamido)salicylic Acid, an Exo-Alkylating Irreversible InhibitorB. R. Baker, William W. Lee, Abelardo P. Martinez, Leonard O. Ross, and Leon GoodmanCite this: J. Org. Chem. 1962, 27, 9, 3283–3295Publication Date (Print):September 1, 1962Publication History Published online1 May 2002Published inissue 1 September 1962https://doi.org/10.1021/jo01056a073RIGHTS & PERMISSIONSArticle Views214Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Computing Impulse Response of Room Acoustics Using the Ray-Tracing Method in Time Domain (2010)

Abstract This paper proposes a new approach for calculating the impulse response of room acoustics. Impulse response provides unique characterization of any discrete lineartime invariant (LTI) systems. We assume that the room is a linear time-invariant system and the impulse response is calculated simply by sending a Dirac Impulse into the system as input and getting the response from the output. Then, the output of the system is represented as a sum of time-shifted weighted impulse responses. Both mathematical justifications for the proposed method and results from simulation software developed to evaluate the proposed approach are presented in detail.
Interaction with Context-Aware Mobile Hand-Held Devices. (2003)

Interaction with context-aware mobile hand-held devices creates new demands for user interfaces and interaction methods. These devices, which detect the use context in order to adapt the device behavior in appropriate means, provide challenging design tasks in the field of human-computer interaction, when the aspects of mobility, small size and reliability have to be taken into account. The device has to meet user’s demands as well in efficiency and acceptability as with the ethical issues in privacy and control. This paper draws together several aspects requiring a specific concern, and introduces the author’s research plan for the considered topic.
Dielectric properties of sol-gel derived barium-strontium-titanate (Ba/sub 0.4/Sr/sub 0.6/TiO/sub 3/) thin films (2000)

The structural and dielectric properties of sol-gel derived barium-strontium-titanate (Ba(0.4)Sr(0.6)TiO(3 )) thin films have been investigated. The as-fired films are found to be amorphous, and films crystallize to a cubic phase after a post deposition annealing at 700 degrees C for one hour in air. The variation of dielectric constant with temperature and field was investigated as a function of film thickness. These films display a nonlinear dielectric response that can be described in terms of a power series expansion of the free energy in polarization as in Landau-Ginzburg-Devonshire approach. The measured room temperature dielectric constant (epsilon') of the film was about 320. The dielectric constant did not show any significant frequency dependence up to 100 kHz. The temperature dependence of dielectric constant exhibited a diffused ferroelectric to paraelectric phase transition at -60 degrees C. The room temperature dielectric constant and magnitude of the dielectric peak at the Curie point was dependent on the thickness of the film. The obtained dielectric data on sol-gel barium strontium titanate thin films on platinized substrates were analyzed in the light of a barrier layer model.
Computationally private information retrieval (extended abstract) (1997)

information ret rieval (PIR) schemes enable a user to access k replicated copies of a database (k z 2), and privately retrieve one of the n bits of data stored in the databases.
Interleukin 2 induces CD8+ T cell-mediated suppression of human immunodeficiency virus replication in CD4+ T cells and this effect overrides its ability to stimulate virus expression. (1995)

The nonlytic suppression of human immunodeficiency virus (HIV) production from infected CD4+ T cells by CD8+ lymphocytes from HIV-infected individuals is one of the most potent host-mediated antiviral activities observed in vitro. We demonstrate that the pleiotropic cytokine interleukin 2 (IL-2), but not IL-12, is a potent inducer of the CD8+ HIV suppressor phenomenon. IL-2 induces HIV expression in peripheral blood or lymph node mononuclear cells from HIV-infected individuals in the absence of CD8+ T cells. However, IL-2 induces CD8+ T cells to suppress HIV expression when added back to these cultures, and this effect dramatically supersedes the ability to IL-2 to induce HIV expression. Five to 25 times fewer CD8+ cells were required to obtain comparable levels of inhibition of viral production if they were activated in the presence of IL-2 as compared with IL-12 or no exogenous cytokine. Furthermore, IL-2 appeared either to induce a qualitative increase in HIV suppressor cell activity or to increase the relative frequency of suppressor cells in the activated (CD25+) CD8+ populations. Analyses of proviral levels in peripheral blood mononuclear cells suggest that CD8+ T cell-mediated lysis of in vivo infected cells is not induced by IL-2. These results have implications for our understanding of the effects of impaired IL-2 production during HIV disease as well as the overall effects of IL-2-based immunotherapy on HIV replication in vivo.
Synthesis of Atactic and Isotactic Poly(1,2-glycerol carbonate)s: Degradable Polymers for Biomedical and Pharmaceutical Applications (2013)

The synthesis and characterization of atactic and isotactic linear poly(benzyl 1,2-glycerol carbonate)s are reported. The poly(benzyl 1,2-glycerol carbonate)s were obtained via the ring-opening copolymerization of rac-/(R)-benzyl glycidyl ether with CO2 using [SalcyCo(III)X] complexes with high carbonate linkage selectivity and polymer/cyclic carbonate selectivity (>99%). Deprotection of the resultant polymers afforded poly(1,2-glycerol carbonate)s with a functionalizable pendant primary hydroxyl group. Poly(1,2-glycerol carbonate) showed a remarkable increase in degradation rate compared to poly(1,3-glycerol carbonate) with a t1/2 ≈ 2-3 days. These polymers fulfill an unmet need for a readily degradable biocompatible polycarbonate.
[Action of atabrine in disorders of cardiac rhythm]. (1950)

Introduction. Only a few authors conducted comparative analyses of early and late health-related quality of life (HRQoL) depending on gender of patients with acute coronary syndrome (ACS) and discussed the factors affecting the late HRQoL in this group. We hypothesized that women with ACS are characterised by worse long-term (6th month follow-up HRQoL) after percutaneous coronary intervention (PCI). To examine the dynamics of changes in HRQoL between the baseline and 6th month follow-up after ACS, depending on gender, and to determine sociodemographic and clinical predictors at baseline, which may have an impact on 6th month follow-up assessment of HRQoL. Material and methods. The study included 140 consecutive patients (70 women and 70 men) with ACS who were subjected to PCI. The patients were divided depending on gender: group I (n = 70) — women with ACS without ST elevation (NSTEMI; n = 14) and those with ST elevation (STEMI; n = 56); group II (n = 70) — men with ACS without ST elevation (NSTEMI; n = 9) and those with ST elevation (STEMI; n = 61). HRQoL was assessed two times (at baseline and 6th month follow-up) of Short Form 36 (SF-36) questionnaire, and the effect of sociodemographic and clinical factors on physical (PCS) and mental (MCS) component summary scores was evaluated. Results. Compared to men, women presented with significantly lower PCS and MCS scores, both at baseline and at6th month-follow-up. On univariate analysis, significantly lower PCS scores were observed among women, patients older than 70 years, physically inactive, not smoking, retired, and diagnosed with depressive symptoms. In contrast, we did not reveal any significant effects of the analysed variables on MCS on univariate analysis. The multivariate stepwise logistic regression analysis identified female gender and age > 70 as significant predictors of 6th month follow-up HRQoL in both PCS and MCS of SF-36. Moreover, marital status, and depression turned out to negatively affect the HRQoL in PCS. Adjusted odds ratio revealed that women were at three- and two-fold greater risk of decreased PCS and MCS, respectively. Conclusions. Among the patients with ACS, women showed lower HRQoL than men, both at baseline and at 6th month follow-up. Both women and men showed improvement in PCS at 6th month follow-up but MCS improvement was observed only for women. The significant baseline predictors of 6th month follow-up HRQoL were female gender, age and marital status.
β-Cyclodextrin/Surface Plasmon Resonance Detection System for Sensing Bitter-Astringent Taste Intensity of Green Tea Catechins (2010)

To develop a methodology for creating a sensor with a receptor for specific taste substances, we focused on constructing a sensing system for the bitter-astringent taste intensity of green tea catechins: (-)-epigallocatechin-3-O-gallate (EGCg), (-)-epicatechin-3-O-gallate (ECg), (-)-epigallocatechin (EGC), and (-)-epicatechin (EC). (1)H NMR titration experiments revealed that beta-cyclodextrin was an adequate receptor for sensing the bitter-astringent taste intensity of catechins. A surface plasmon resonance (SPR) system immobilized beta-cyclodextrin indicated larger responses for the gallate-type catechins in comparison to the non-gallate-type catechins. These responses corresponded to the tendency of the bitter-astringent taste intensity of the catechins felt by humans. Furthermore, the SPR system detected the larger stability of the complex between the gallate-type catechins and beta-cyclodextrin, which was interpreted as the aftertaste produced in humans by the gallate-type catechins. These results demonstrate that the beta-cyclodextrin/SPR system can sense the bitter-astringent taste intensity of the green tea catechins similar to human gustation. The methodology presented in this study can be used as a basic strategy for developing taste sensors with specific receptor functions.
Abstract 2952: Image-guided miRNA therapy for metastatic breast cancer (2012)

Abstract Metastases, and not the primary tumor from which they originate, are the main reason for mortality from breast carcinoma. New therapeutic approaches for metastatic breast cancer are urgently needed. The specific involvement of miRNAs in the development of metastases has been recently described and identified microRNA-10b (miR-10b) in initiation of breast cancer invasion and metastasis (Ma et al, Nature, 2007). Here, we describe a nanodrug for image-guided therapy of lymph node metastatic breast cancer. It consists of RGD-targeted ultrasmall magnetic nanoparticles that mediate their therapeutic effect by delivering locked nucleic acid to knockdown microRNA-10b (MN-anti-miR10b). Nanodrug bearing scrambled locked nucleic acid (MN-scr-miR) was also synthesized. The size and composition of the nanoparticles promote their extended persistence in the circulation (blood half-life &gt;12 hrs) and transcytosis into the tumoral and lymph node interstitium. The nanodrug is detectable by magnetic resonance and optical imaging and is designed so that it targets both primary tumor cells and lymph node metastases. We show that treatment of invasive human breast tumor cells in vitro expressing luciferase (MDA-MB-231-luc) with the nanodrug results in an 88% downregulation of miRNA-10b with the application of just 1.5 nmoles/ml of LNA and abolishes the invasion and migration of the tumor cells. In vivo, we showed that the nanodrug could be delivered to primary tumors as well as to lymph nodes and lymph node and lung metastasis. Therapeutic treatment of animal bearing orthotopic MDA-MB-231-luc tumors was performed with tail vein injections (10mg/kg of iron) delivered once a week for four weeks. Two therapeutic scenarios were used: 1) preventing tumor cell dissemination from the primary tumor beginning prior to the formation of detectable lymph node metastases and 2) beginning the treatment after the formation of lymph node metastasis but prior to metastasis to the lungs. In scenario (1) we observed that by the end of the treatment course, bioluminsecence signal from the tumors in the experimental animals treated with MN-anti-miR10b was at pre-metastatic levels, indicating a prevention of tumor cell metastasis from the primary tumor to lymph nodes. In contrast, there was visible dissemination of tumor cells to the lymph nodes of control animals treated with the MN-scr-miR. This therapeutic effect was highly reproducible. In scenario (2) there was a 20-fold increase in lymph node metastatic burden in controls treated with MN-scr-miR. By contrast, in the experimental animals treated with MN-anti-miR10b, there was a dramatic reduction of metastatic progression (p &lt; 0.001, n = 6) and a prevention of tumor cell dissemination to the lungs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2952. doi:1538-7445.AM2012-2952
Annotation and Image Markup: Accessing and Interoperating with the Semantic Content in Medical Imaging (2009)

The annotation and image markup project makes large distributed collections of medical images in cyberspace and hospital information systems accessible using an information model of image content and ontologies. Interest in applying semantic Web technologies to the life sciences continues to accelerate. Biomedical research is increasingly an online activity as scientists combine and explore different types of data in cyberspace, putting together complementary views on problems that lead to new insights and discoveries. An e-Science paradigm is thus emerging; the biomedical community is looking for tools to help access, query, and analyze a myriad of data in cyberspace. Specifically, the biomedical community is beginning to embrace technologies such as ontologies to integrate scientific knowledge, standard syntaxes, and semantics to make biomedical knowledge explicit, and the semantic Web to establish virtual collaborations.
Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. (1993)

The roles of active oxygen, lipid peroxidation, and the antioxidative defence mechanism in gastric mucosal injury induced by treatment with indomethacin in rats were investigated. The total area of gastric erosions and concentration of lipid peroxides in the gastric mucosa increased with time after administration of indomethacin (20 mg/kg, orally). The alpha-tocopherol:total cholesterol ratio in serum was significantly decreased and the activity of glutathione peroxidase, an important enzyme to scavenger of lipid peroxides, was inhibited by the administration of indomethacin. Treatments with superoxide dismutase and catalase inhibited the increases in gastric mucosal erosions and lipid peroxides in the gastric mucosa, and the reduction of serum alpha-tocopherol. Treatment with these scavengers did not improve the decreased glutathione peroxidase activity. These findings suggest that active oxygen species and lipid peroxidation play an important part in the pathogenesis of gastric mucosal injury induced by indomethacin, and that the decreased glutathione peroxidase activity aggravated the injury due to accelerated accumulation of hydrogen peroxide and lipid peroxides in the gastric mucosal cell.