gebhart/patrepeval huggingface dataset:
Antitumor Agents. 282. 2′-(<i>R</i>)-<i>O</i>-Acetylglaucarubinone, a Quassinoid from<i>Odyendyea gabonensis</i>As a Potential Anti-Breast and Anti-Ovarian Cancer Agent (2010)

A new quassinoid, designated 2'-(R)-O-acetylglaucarubinone (1), and seven known quassinoids (2-8) were isolated, using bioactivity-guided separation, from the bark of Odyendyea gabonensis (Pierre) Engler [syn. Quassia gabonensis Pierre]. The structure of 1 was determined by spectroscopic analysis and by semisynthesis from glaucarubolone. Complete (1)H and (13)C NMR assignments of compounds 1-8 were also established from detailed analysis of two-dimensional NMR spectra, and the reported configurations in odyendene (7) and odyendane (8) were corrected. Compound 1 showed potent cytotoxicity against multiple cancer cell lines. Further investigation using various types of breast and ovarian cancer cell lines suggested that 1 does not target the estrogen receptor or progesterone receptor. When tested against mammary epithelial proliferation in vivo using a Brca1/p53-deficient mice model, 1 also caused significant reduction in mammary duct branching.
Most frequent scenario for recurrent Candida vaginitis is strain maintenance with "substrain shuffling": demonstration by sequential DNA fingerprinting with probes Ca3, C1, and CARE2 (1996)

The following three basic scenarios have emerged for the genetic relatedness of strains in recurrent vaginal candidiasis: strain maintenance without genetic variation, strain maintenance with minor genetic variation, and strain replacement. To test the frequency of each of the three scenarios, the genetic relatedness of Candida albicans isolates from each of 18 patients with recurrent infections was assessed by sequential DNA fingerprinting with the following three probes: the Ca3 probe; the C1 probe, a subfragment of the Ca3 probe which hybridizes to hypervariable genomic fragments; and the unrelated CARE2 probe. In each of the 18 patients with recurrent infections, the same strain was responsible for sequential infections, suggesting that the predominant scenario is strain maintenance. However, in 56% of these patients, the strain exhibited minor genetic variations in sequential infections. These changes were not found to be progressive. Rather, the changes suggest that substrains of an established infecting strain are shuffled in sequential infections. Results are also presented that in 45% of patients with recurrent infections, oral and vulvovaginal isolates were identical, in 35% they were highly related but not identical, and in 20% they were unrelated. These results differ markedly from those for commensal isolates simultaneously cultured from the oral cavity and vulvovaginal region of healthy individuals. Finally, it is demonstrated that in all eight cases in which C. albicans was isolated from both the male sexual partner of the patient with a recurrent infection and the patient, an isolate from the male partner was identical or highly related to the vulvovaginal strain. These results demonstrate that in patients with recurrent vulvovaginitis, a single strain usually dominates both in the different body locations of the patient and in the male partner and that it is maintained through sequential infections. However, in patients with recurrent infections, different substrains of the established clone dominate in an apparently random fashion, a process that we refer to as "substrain shuffling".
WHO tackles food inequalities: Europe's first comprehensive Food and Nutrition Action Plan debate, 8–10 November 1999, Malta (2000)

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Sequence-Defined Polypeptide−Polymer Conjugates Utilizing Reversible Addition Fragmentation Transfer Radical Polymerization (2005)

Straightforward solid-phase-supported synthesis routes were presented to obtain novel oligopeptide-based reversible addition fragmentation transfer (RAFT) agents. These approaches include the coupling of a functional RAFT agent to a resin-bound peptide and the functionality switch of an oligopeptide ATRP macroinitiator into an oligopeptide transfer agent. The solid-phase-supported methods allowed easy purification of the transfer agents, making difficult column purification steps unnecessary. Well-defined conjugates comprising sequence-defined peptides and synthetic polymers could be accessed by applying RAFT polymerization techniques in combination with the peptide macrotransfer agents. Polymerization reactions of n-butyl acrylate were performed in solution, yielding peptide−polymer conjugates with controllable molecular weight and low polydispersities of around 1.1. The peptide−polymer conjugates were characterized using 1H NMR spectroscopy and size exclusion chromatography (SEC), while the incorporation of the oligopeptide into the synthetic polymer and the preservation of the chirality were shown by circular dichroism (CD) spectroscopy.
The Essence of Three-Phase PFC Rectifier Systems—Part II (2013)

The second part of the essence of three-phase PFC Rectifier Systems is dedicated to a comparative evaluation of four active three-phase PFC rectifiers that are of interest for industrial application: the active six-switch boost-type PFC rectifier, the Vienna Rectifier (VR), the active six-switch buck-type PFC rectifier, and the Swiss Rectifier. Typical dynamic feed-back control structures of the considered topologies are shown, and analytical equations for calculating the current stresses of the power semiconductors are provided. In addition, EMI filtering is discussed. The rectifier systems are assessed and compared based on simple and demonstrative performance indices such as the semiconductor stresses, the required semiconductor chip area, the volume of the main passive components, the DM and CM conducted EMI noise levels, and the efficiency. Two implementation variants, a more advanced one using SiC JFETs and SiC Schottky diodes and one using Si IGBTs and SiC Schottky diodes, are considered. The comparison is extended with selected examples of hardware demonstrators of VR systems that are optimized for efficiency and/or power density. This allows to determine the tradeoff between efficiency and power density and to quantify a typical efficiency versus power density limit (Pareto-Front) for practical three-phase PFC rectifier systems using standard printed circuit board interconnection technology.
3-D Devices and Virtual Reality in Human Animation (1991)

In this paper, we show how 3-D input devices used in virtual reality may drastically change the way of designing animation scenes.We analyze the various stages of animation production and show when and how these new concepts/devices may be involved into the creation process.We illustrate this new approach by describing the 5th Dimension animation system developed in our laboratories.We emphasize typical applications in surface sculpting, facial animation, cloth design, camera path design, gesture input and animatoractor communication.
Distal Venous Arterialization for Lower Limb Salvage: Angiographic Appearances and Interventional Procedures (2001)

Approximately 14%-20% of patients with critical lower limb ischemia are unsuited for distal arterial reconstruction and face major distal amputation. Distal venous arterialization is a unique procedure in which the venous bed is used as an alternative conduit for perfusion of peripheral tissues. Eighteen patients with stage IV Fontaine critical lower limb ischemia underwent venous arterialization. Preoperative angiographic findings confirmed the absence of any below-knee continuous arterial vessels. The most distal satisfactory artery was used for proximal bypass anastomosis, and venous valves were destroyed with Parsonnet probes, cutting balloons, Fogarty catheters, and valvulotomes under radiologic guidance. All patients underwent intra- and postoperative angiography of the venous grafts and the distal venous bed. Primary and secondary graft patencies were 66% and 72%, respectively, at a mean follow-up of 25 months. The limb salvage rate was 83% overall and 75% at 2-year follow-up. Vascular imaging is essential in selecting and following up patients and in determining the appropriate intraoperative procedure.
Attenuation of high energy marine towed‐streamer noise (2011)

Marine seismic data have been traditionally contaminated by bulge waves propagating along the streamers that were generated by tugging and strumming from the vessel, paravanes, tail buoys, and lead‐in cables. With the progress of streamer technology bulge‐wave interference has been significantly reduced. However, weather and flow noise still affects marine seismic data. The level of cross‐flow‐induced noise is increased when the data are acquired during turns or along circles, like in Coil shooting, and when marine currents are strong. In this paper, we present a new technique to attenuate towed‐streamer noise acquired in these conditions. The method has been used successfully to process coil and wide‐azimuth data in the Gulf of Mexico and offshore Brazil.
A thermodynamic free energy function for potassium niobate (2009)

A thermodynamic free energy function in the form of an eighth-order polynomial has been developed for bulk potassium niobate (KNbO3), based on the Landau–Ginsburg–Devonshire phenomenological theory. The obtained free energy function successfully models the ferroelectric single domain (intrinsic) properties of KNbO3, including the three sequential phase transition temperatures as well as polarizations, dielectric constants, and lattice constants along the whole ferroelectric temperature range. It is applicable to explaining and predicting the extrinsic contributions such as hydrostatic pressure on the bulks properties and substrate constraints on the thin films properties.
A Financial Tale of Two Cities (2007)

To evaluate some of the highlights and reforms of Australia's financial markets over two decades, Jim Bain, retired stockbroker, banker and author of 'A Financial Tale of Two Cities' (UNSW Press, 2007) and Edna Carew, finance writer, addressed The Sydney Institute on Tuesday 14 August 2007. (Edna Carew's speech is included in this issue of Sydney Papers.) Jim Bain discusses the growth of Australia's financial sector in Sydney and Melbourne. He argues that the welcoming of new merchant banks, foreign banks and fund managers over the years has made Sydney the winner in the struggle to become Australia's leading financial centre.
The influence of solid‐state microstructure on the origin and yield of long‐lived photogenerated charge in neat semiconducting polymers (2011)

Abstract The influence of solid‐state microstructure on the optoelectronic properties of conjugated polymers is widely recognized, but still poorly understood. Here, we show how the microstructure of conjugated polymers controls the yield and decay dynamics of long‐lived photogenerated charge in neat films. Poly(3‐hexylthiophene) was used as a model system. By varying the molecular weight, we drive a transition in the polymer microstructure from nonentangled, chain‐extended, paraffinic‐like to entangled, semicrystalline ( M W = 5.5–347 kg/mol). The molecular weight range at which this transition occurs ( M W = 40–50 kg/mol) can be deduced from the drastic change in elongation at break found in tensile tests. Linear absorption measurements of free‐exciton bandwidth and time‐resolved microwave conductivity (TRMC) measurements of transient photoconductance track the concomitant evolution in optoelectronic properties of the polymer as a function of M W . TRMC measurements show that the yield of free photogenerated charge increases with increasing molecular weight in the paraffinic regime and saturates at the transition into the entangled, semicrystalline regime. This transition in carrier yield correlates with a sharp transition in free‐exciton bandwidth and decay dynamics at a similar molecular weight. We propose that the transition in microstructure controls the yield and decay dynamics of long‐lived photogenerated charge. The evolution of a semicrystalline structure with well‐defined interfaces between amorphous and crystalline domains of the polymer is required for spatial separation of the electron and hole. This structural characteristic not only largely controls the yield of free charges, but also serves as a recombination center, where mobile holes encounter a bath of dark electrons resident in the amorphous phase and recombine with quasi first‐order kinetics. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011
Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein−Protein Interaction (2017)

Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired resistance so often observed with standard anticancer regimens. As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. The TLS DNA polymerase Rev1 serves as an integral scaffolding protein that mediates the assembly of the active multiprotein TLS complexes. Protein-protein interactions (PPIs) between the C-terminal domain of Rev1 (Rev1-CT) and the Rev1-interacting region (RIR) of other TLS DNA polymerases play an essential role in regulating TLS activity. To probe whether disrupting the Rev1-CT/RIR PPI is a valid approach for developing a new class of targeted anticancer agents, we designed a fluorescence polarization-based assay that was utilized in a pilot screen for small molecule inhibitors of this PPI. Two small molecule scaffolds that disrupt this interaction were identified, and secondary validation assays confirmed that compound 5 binds to Rev1-CT at the RIR interface. Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.
Genetic analysis of theAPAF1 gene in male germ cell tumors (2000)

Cytogenetic and molecular analyses have shown that the chromosome band 12q22 is recurrently deleted in male germ cell tumors (GCTs), indicating the presence of a candidate tumor suppressor gene (TSG) in this region. To identify the TSG, we mapped the APAF1 gene, a proapoptotic mammalian homologue of ced-4, to chromosomal band 12q22, that suggested that this might be the candidate deleted gene in GCTs. We further localized the gene between the polymorphic markers D12S1671 and D12S1082 at 12q22 to determine the role of APAF1 in the pathogenesis of GCT, and we characterized its normal genomic structure and analyzed its alterations in GCTs. The APAF1 gene comprises 27 exons, with the coding region spanning 26. The region containing APAF1 was found to be deleted in GCT by fluorescence in situ hybridization analysis, but without evidence of coding sequence alterations. RT-PCR and Western blot analysis showed APAF1 gene expression at detectable levels in all GCT cell lines analyzed. An aberrant-sized APAF1 protein was seen in one cell line. This and 2 other cell lines carrying APAF1 deletions also exhibited defects in dATP-mediated caspase-3 activation. Caspase-3 activity was effectively restored by addition of recombinant caspase-9 and APAF1 proteins, and to a lesser extent by caspase-9 alone, but not by APAF1 alone. These data do not support a TSG role for APAF1, but defects in other components of the apoptotic pathway that may be related to 12q22 deletion cannot be ruled out. Genes Chromosomes Cancer 28:258-268, 2000.
Functional role of interleukin 1 in periodontal disease: induction of interleukin 1 production by Bacteroides gingivalis lipopolysaccharide in peritoneal macrophages from C3H/HeN and C3H/HeJ mice (1985)

Hot phenol-water-extracted lipopolysaccharide (LPS) from Bacteroides gingivalis 381 was purified by Sephadex G-100 chromatography with Tris buffer supplemented with sodium deoxycholate and EDTA (B-LPS). In the present study, B-LPS was examined for its ability to induce interleukin 1 (IL-1) production, a mitogenic response, and macrophage activation in LPS high-responder C3H/HeN and low-responder C3H/HeJ mice. A significant increase in IL-1 production was observed in C3H/HeN and C3H/HeJ peritoneal macrophages treated with various doses (1.0 to 50 micrograms/ml) of B-LPS. IL-1 production by C3H/HeN macrophages treated with B-LPS (10 micrograms/ml) was about seven times greater than that by C3H/HeJ macrophages. However, the IL-1 production induced by B-LPS (10 micrograms/ml) in C3H/HeN macrophages was four times lower compared with that induced by Escherichia coli O111 B4 LPS. Also, a significant increase in IL-1 production was found in human monocytes stimulated with B-LPS. That B-LPS-induced IL-1 exhibits some molecular weight heterogeneity was indicated from Sephadex G-75 gel filtration profiles. A significant, high mitogenic response by whole spleen cells with 1 X 10(5) to 5 X 10(4) cells of either mouse strain per well treated with B-LPS (10 to 50 micrograms/ml) was observed. However, the response of C3H/HeJ mice was less than that of the C3H/HeN strain. Also, glucose consumption assays indicated that enhanced macrophage activation occurred in C3H/HeN but not in C3H/HeJ mice treated with B-LPS. In light of recent studies showing that IL-1 stimulates bone resorption in a mouse calvaria system and collagenase production in fibroblasts, we suggest that B-LPS-induced IL-1 may play a significant role in the pathogenesis of adult periodontal disease.
Comparison of Prediction Methods when Only a Few Components are Relevant (1994)

Abstract We consider prediction in a multiple regression model where we also look on the explanatory variables as random. If the number of explanatory variables is large, then the common least squares multiple regression solution may not be the best one. We give a methodology for comparing certain alternative prediction methods by asymptotic calculations and perform such a comparisons for four specific methods. The results indicate that none of these methods dominates the others, and that the difference between the methods typically (but not always) is small when the number of observations is large. In particular, principal component regression does well when the eigenvalues corresponding to components not correlated with the dependent variables (i.e., the irrelevant eigenvalues) are extremely small or extremely large. Partial least squares regression does well for intermediate irrelevant eigenvalues. A maximum likelihood-type method dominates the others asymptotically, at least in the case of one relevant component.
Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge (2001)

Periventricular leukomalacia is one of the main causes of cerebral palsy. Perinatal white matter lesions associated with cerebral palsy appears to involve glutamate excitotoxicity and excess free radical production. When injected intracerebrally into newborn mice, the glutamatergic analog ibotenate induces white matter cysts mimicking human periventricular leukomalacia. Melatonin acts on specific receptors. It also exhibits intrinsic free radical scavenging properties. The goal of the present study is to determine whether melatonin can protect against excitotoxic lesions induced by ibotenate in newborn mice. Mice that received intraperitoneal melatonin had an 82% reduction in size of ibotenate-induced white matter cysts when compared with controls. Although melatonin did not prevent the initial appearance of white matter lesions, it did promote secondary lesion repair. Axonal markers supported the hypothesis that melatonin induced axonal regrowth or sprouting. The protective effects of melatonin were suppressed by coadministration of luzindole, a melatonin receptor antagonist. Forskolin, an adenylate cyclase activator, prevented the protective effects of melatonin; inhibitors of protein kinase C and mitogen-associated protein kinase had no detectable effect. Melatonin and derivatives that block cAMP production through activation of melatonin receptors could represent new avenues for treating human periventricular leukomalacia.
Generation narrow focusing beams in plasma cathode electron guns (2008)

The work purpose is producing of the focused electron beam with minimal diameter and divergence in a plasma cathode gun. Researches of influence of an emitting plasma surface position in electron-optical system of a gun on electron beam parameters are executed. The measurement technique of current density distribution is developed. For the first time in system with the plasma emitter beams with energy 30-60 keV, power about some kilowatt, with diameter of the order 250 microns and a divergence no more than 0,05 degrees are received.
Switching Redox-Active Sites by Valence Tautomerism in Prussian Blue Analogues A<sub><i>x</i></sub>Mn<sub><i>y</i></sub>[Fe(CN)<sub>6</sub>]·<i>n</i>H<sub>2</sub>O (A: K, Rb): Robust Frameworks for Reversible Li Storage (2010)

The discovery of a new electrode material that provides a reversible Li ion insertion/extraction reaction is of primary importance for Li ion batteries. In this report, electrochemical Li ion insertion/extraction in valence tautomeric Prussian blue analogues AxMny[Fe(CN)6] (A: K, Rb) was investigated. Ex situ X-ray diffraction experiments revealed that the K salt without the valence tautomerism exhibits the Li ion insertion/extraction with a redox process of an Fe ion, while the Rb salt with the valence tautomerism exhibits that with a redox process of a Mn ion. Regardless of the redox-active metal ions, highly reversible Li ion storage was achieved. The electronic structure changes during the Li ion insertion/extraction are confirmed by XPS experiments.
Cyclometalated titanium and zirconium complexes stabilised by a new silylmethylene-linked tetradentate triamidophosphine (2016)

The silylmethylene-linked triamidophosphine P(CH2SiMe2NHPh)3 was isolated in form of its tri-lithium salt Li3[P(CH2SiMe2NPh)3]·2.5Et2O (1·2.5Et2O) and employed for the synthesis of titanium and zirconium complexes. Starting from 1·2.5Et2O, the chlorido complexes [κ(4)-N,N,N,P-PN3]MCl (4-M, M = Ti, Zr) were prepared and examined with respect to alkylation. Upon reaction of 4-Ti with (trimethylsilyl)methyl lithium, intra-ligand cyclometalation at one of the ortho-N-phenyl positions was observed and the resulting thermally stable titanazetidine [κ(5)-N,N,N,P,C-N2P(NC)]Ti (5-Ti) isolated. Similarly, the related zirconazetidine [κ(5)-N,N,N,P,C-N2P(NC)]Zr(THF) (5-Zr) was isolated upon reaction of 4-Zr with Bn2Mg(THF)2. Using LiCH2PMe2 as alkyl transfer reagent, both complexes 4-M were converted to the corresponding phosphametallacyclopropanes [κ(4)-N,N,N,P-PN3]M(κ(2)-C,P-CH2PMe2) (7-M, M = Ti, Zr). Upon gentle heating, complexes 7-M were cleanly converted to the cyclometalated species 5-M and trimethylphosphine. These results are discussed in the context of related amidophosphine and triamidoamine complexes.