gebhart/patrepeval huggingface dataset:
State of the Art in Geometry Compression (2000)

Very large 3D models documenting architectural designs, heritage monuments, power plants and mechanical CAD designs are being increasingly deployed in various applications involving interactive visualization and network-based access. More often than not, the complexity of these 3D models far exceeds the limits of what can be quickly downloaded at popular connection speeds and what can be easily stored and rendered for interactive exploration on personal desktops, even when additionally fitted with affordable 3D acceler-ator hardware. Compression schemes for such very large 3D geo-metric models have thus become a subject of intense study in recent years. In this report, we present: (a) an overview of the state of the art in compression of 3D polygonal models, (b) a classification scheme for large 3D polygonal models, (c) a classification of strategies for compression of these models, (d) a scheme for evaluation of geome-try compression algorithms, and (e) a detailed survey of the relevant work reported in the literature till date. 1
Smart surveillance: applications, technologies and implications (2004)

Smart surveillance, is the use of automatic video analysis technologies in video surveillance applications. This paper attempts to answer a number of questions about smart surveillance: What are the applications of smart surveillance? What are the system architectures for smart surveillance? What are the key technologies? What are the some of the key technical challenges? and What are the implications of smart surveillance, both to security and privacy?.
Single mode high-contrast subwavelength grating vertical cavity surface emitting lasers (2008)

We present a single mode vertical-cavity surface-emitting laser (VCSEL) utilizing a single-layer, high-contrast subwavelength grating (HCG) based top mirror, which provides both the ultrahigh reflectivity and lateral transverse modes control. Experimentally, we demonstrate that merely 11 HCG stripes with a thickness of 230nm are required to achieve lasing operation. The finite area of HCG, in combination with an oxide aperture of 2–6μm, effectively discriminates the higher-order transverse modes in VCSELs with a side mode suppression ratio of ⩾40dB. Furthermore, a single (first high-order transverse) mode, high output power of 2.3mW laser was achieved from a VCSEL with a 10μm oxide aperture.
The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression (2000)

IL-12 is a central immunoregulatory cytokine that promotes cell-mediated immune responses and the differentiation of naive CD4+ cells into Th1 cells. We and others have demonstrated that the Stat4 is critical for IFN-gamma production by activated T cells and Th1 cells. However, several studies have suggested that other pathways may be involved in IL-12-stimulated IFN-gamma expression. In this report we demonstrate that IL-12 activates mitogen-activated protein kinase kinase 3/6 (MKK) and p38 mitogen-activated protein kinase (MAPK), but not p44/42 (ERK) or stress-activated protein kinase/c-Jun N-terminal kinase MAPK. The activation of p38 MAPK is required for normal induction of IFN-gamma mRNA and IFN-gamma secretion by IL-12 in activated T cells and Th1 cells. Importantly, IL-12-stimulated p38 MAPK effector functions occur through a Stat4-independent mechanism and correlate with increased serine phosphorylation of activating transcription factor-2. The requirement for p38 MAPK in IL-12 function suggests that this pathway may be an important in vivo target for the anti-inflammatory actions of p38 MAPK inhibitors.
Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells (1997)

Mutations in the presenilin genes, PS1 and PS2, cause a major portion of early onset familial Alzheimer's disease (FAD). The biological roles of the presenilins and how their pathological mutations confer FAD are unknown. In this study, we set out to examine the processing and degradation pathways of PS2. For regulated expression of PS2, we have established inducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactivator. Western blot analysis revealed that PS2 was detected as an approximately 53-55-kDa polypeptide (54-kDa PS2) as well as a high molecular mass form (HMW-PS2). Using a stably transfected, inducible cell system, we have found that PS2 is proteolytically cleaved into two stable cellular polypeptides including an approximately 20-kDa C-terminal fragment and an approximately 34-kDa N-terminal fragment. PS2 is polyubiquitinated in vivo, and the degradation of PS2 is inhibited by proteasome inhibitors, N-acetyl-L-leucinal-L-norleucinal and lactacystin. Our studies suggest that PS2 normally undergoes endoproteolytic cleavage and is degraded via the proteasome pathway.
An evidential sensor model for Velodyne scan grids (2014)

For the development of driving assistance systems and autonomous vehicles, a reference perception equipment including navigable space determination and obstacles detection is a key issue. The Velodyne sensor which provides high definition and omnidirectional information can be used for this purpose. Nevertheless, when scanning around the vehicle, uncertainty necessarily arises due to unperceived areas and noisy measurements. This paper proposes an inverse evidential model for the Velodyne in order to exploit its measurements in a 2D occupancy grid mapping framework. The evidential sensor model interprets the data acquired from the Velodyne and successively maps it to a Carthesian evidential grid using a fusion process based on the least commitment principle to guarantee information integrity. Experimental results prove that this approach can handle efficiently the uncertainties of the sensor and thus a highly reliable local reference map near the vehicle can be built for every timestamped perception system that needs evaluation or calibration.
Subpixel Point Spread Function Estimation from Two Photographs at Different Distances (2012)

In most digital cameras, and even in high-end digital single lens reflex cameras, the acquired images are sampled at rates below the Nyquist critical rate, causing aliasing effects. This work introduces an algorithm for the subpixel estimation of the point spread function (PSF) of a digital camera from aliased photographs. The numerical procedure simply uses two fronto-parallel photographs of any planar textured scene at different distances. The mathematical theory developed herein proves that the camera PSF can be derived from these two images, under reasonable conditions. Mathematical proofs supplemented by experimental evidence show the well-posedness of the problem and the convergence of the proposed algorithm to the camera in-focus PSF. An experimental comparison of the resulting PSF estimates shows that the proposed algorithm reaches the accuracy levels of the best nonblind state-of-the-art methods.
Functional Interaction between p/CAF and Human Papillomavirus E2 Protein (2002)

p300/CREB-binding protein-associated factor (p/CAF), a transcriptional co-activator, interacts with co-activator p300/CBP and acidic transcription factors. p/CAF mediates transcriptional activation by acetylating nucleosomal histones and cellular factors. Previously we reported that CBP binds to human papillomavirus E2 and activates E2-dependent transcription (Lee, D., Lee, B., Kim, J., Kim, D. W., and Choe, J. (2000) J. Biol. Chem. 275, 7045-7051). Here we show that p/CAF binds to the human papillomavirus E2 protein in vivo and in vitro and activates E2-dependent transcription. CBP along with p/CAF synergistically activates E2-dependent transcription. In addition, the histone acetylase activity of p/CAF is required for efficient activation of E2 transcriptional activity. These results suggest that p/CAF is a transcriptional co-activator of the human papillomavirus E2 protein.
Application of overlay techniques to network monitoring (2008)

Measurement and monitoring are important for correct and efficient operation of a network, since these activities provide reliable information and accurate analysis for characterizing and troubleshooting a network’s performance. The focus of network measurement is to measure the volume and types of traffic on a particular network and to record the raw measurement results. The focus of network monitoring is to initiate measurement tasks, collect raw measurement results, and report aggregated outcomes. Network systems are continuously evolving: besides incremental change to accommodate new devices, more drastic changes occur to accommodate new applications, such as overlay-based content delivery networks. As a consequence, a network can experience significant increases in size and significant levels of long-range, coordinated, distributed activity; furthermore, heterogeneous network technologies, services and applications coexist and interact. Reliance upon traditional, point-to-point, ad hoc measurements to manage such networks is becoming increasingly tenuous. In particular, correlated, simultaneous 1-way measurements are needed, as is the ability to access measurement information stored throughout the network of interest. To address these new challenges, this dissertation proposes OverMon, a new paradigm for edge-to-edge network monitoring systems through the application of overlay techniques. Of particular interest, the problem of significant network overheads caused by normal overlay network techniques has been addressed by constructing overlay networks with topology awareness - the network topology information is derived from interior gateway protocol (IGP) traffic, i.e. OSPF traffic, thus eliminating all overlay maintenance network overhead. Through a prototype that uses overlays to initiate measurement tasks and to retrieve measurement results, systematic evaluation has been conducted to demonstrate the feasibility and functionality of OverMon. The measurement results show that OverMon achieves good performance in scalability, flexibility and extensibility, which are important in addressing the new challenges arising from network system evolution. This work, therefore, contributes an innovative approach of applying overly techniques to solve realistic network monitoring problems, and provides valuable first hand experience in building and evaluating such a distributed system.
Atrasentan for the treatment of diabetic nephropathy (2017)

Endothelin-1 (ET-1) is the most potent vasoconstrictor, and is involved in the renal regulation of salt and water homeostasis. When produced in excess in the kidney, ET-1 promotes proteinuria and tubulointerstitial injury. There is great interest in the clinical use of endothelin receptor antagonists (ERAs) in chronic kidney disease (CKD), mainly in diabetic nephropathy (DN). Areas covered: Physiopathological actions of ET-1 on the kidney. Both dual ETAR/ET<sub>B</sub>R (bosentan) or ET<sub>A</sub>R specific endothelin antagonists (avosentan and atrasentan, among others), which have progressed to early clinical development, with particular emphasis on atrasentan. Expert opinion: Different phase I and II clinical trials with ERAs in DN, mostly with atrasentan, have shown that these drugs have a marked anti-proteinuric effect on residual proteinuria when administered as add-on therapy in addition to ACEi or ARAII treatment. In the past few years, a series of randomized controlled trials investigating new approaches to DN have provided negative or inconclusive data, or even were terminated due to safety concerns or lack of efficacy. Therefore, we eagerly but cautiously await the results of the ongoing SONAR trial with atrasentan in more than 4,000 patients including assessment of renal and cardiovascular hard-end points (estimated primary completion date, July 2018).
Morphology of polymers precipitated from a supercritical solvent (1992)

Abstract The precipitation of polymers via the rapid expansion of a supercritical chlorodifluoromethane solution to ambient conditions across a fine diameter capillary has been studied experimentally. The morphology of the polymers precipitated—polycaprolactone, poly(methyl methacrylate) and a styrene/methyl methacrylate block copolymer—is influenced strongly by conditions of the expansion process. Conditions of high temperature, high polymer concentration, low pressure or low capillary L/D ratio enhance the formation of high aspect ratio fibers, while opposite conditions favor the formation of spherical particles of micron size. Each of the conditions favoring fiber formation favors precipitation farther upstream in the expansion process. Based on one‐dimensional compressible flow calculations using a virial equation of state for pure solvent, it is proposed that fiber formation occurs when a polymer‐rich phase is rejected from solution in the entry region to the capillary. The location of precipitation is shown to be crucial in determining the characteristic time scale for the density reduction process, which may be as small as 10 −7 s.
LA POLITICA DE EDUCACION CONTINUA, PILAR DEL DESARROLLO DEL PAIS (1984)

EL PASADO 16 DE AGOSTO, EL LICENCIADO FRANCISCO CASANOVA ALVAREZ, DIRECTOR DE LA ESCUELA NACIONAL DE ESTUDIOS PROFESIONALES ACATLAN, INAUGURO EL ENCUENTRO UNIVERSITARIO DE EDUCACION CONTINUA.
Structure of the mid-region of tropomyosin: Bending and binding sites for actin (2005)

Tropomyosin is a two-chain α-helical coiled coil whose periodic interactions with the F-actin helix are critical for thin filament stabilization and the regulation of muscle contraction. Here we deduce the mechanical and chemical basis of these interactions from the 2.3-Å-resolution crystal structure of the middle three of tropomyosin's seven periods. Geometrically specific bends of the coiled coil, produced by clusters of core alanines, and variable bends about gaps in the core, produced by isolated alanines, occur along the molecule. The crystal packing is notable in signifying that the functionally important fifth period includes an especially favorable protein-binding site, comprising an unusual apolar patch on the surface together with surrounding charged residues. Based on these and other results, we have constructed a specific model of the thin filament, with the N-terminal halves of each period (i.e., the so-called “α zones”) of tropomyosin axially aligned with subdomain 3 of each monomer in F-actin.
Efficient rendering of projective model for image-based visualization (2002)

This work describes a method for synthesizing correct virtual images of a real scene, described by a set of uncalibrated reference images. The approach used is rendering a projective 3D model. Projective model reconstruction and positioning a projective virtual camera are not addressed. First, the algorithm transfers the vertices of triangles in the triangulated model and then warps interiors of triangles. Hidden faces are removed by z-buffering. The algorithm is more efficient than the ray-tracing-like algorithm for virtual view synthesis by Laveau and Faugeras (1996).
SV40 T antigen <i>alone</i> drives karyotype instability that precedes neoplastic transformation of human diploid fibroblasts (1990)

To define the role of SV40 large T antigen in the transformation and immortalization of human cells, we have constructed a plasmid lacking most of the unique coding sequences of small t antigen as well as the SV40 origin of replication. The promoter for T antigen, which lies within the origin of replication, was deleted and replaced by the Rous sarcoma virus promoter. This minimal construct was co-electroporated into normal human fibroblasts of neonatal origin along with a plasmid containing the neomycin resistance gene (neo). Three G418-resistant, T antigen-positive clones were expanded and compared to three T antigen-positive clones that received the pSV3neo plasmid (capable of expressing large and small T proteins and having two origins of replication). Autonomous replication of plasmid DNA was observed in all three clones that received pSV3neo but not in any of the three origin minus clones. Immediately after clonal expansion, several parameters of neoplastic transformation were assayed. Low percentages of cells in T antigen-positive populations were anchorage independent or capable of forming colonies in 1% fetal bovine serum. The T antigen-positive clones generally exhibited an extended lifespan in culture but rarely became immortalized. Large numbers of dead cells were continually generated in all T antigen-positive, pre-crisis populations. Ninety-nine percent of all T antigen-positive cells had numerical or structural chromosome aberrations. Control cells that received the neo gene did not have an extended life span, did not have noticeable numbers of dead cells, and did not exhibit karyotype instability. We suggest that the role of T antigen protein in the transformation process is to generate genetic hypervariability, leading to various consequences including neoplastic transformation and cell death.
Computational Models for Predicting Interactions with Cytochrome p450 Enzyme (2006)

Cytochrome p450 (CYP) enzymes are predominantly involved in Phase 1 metabolism of xenobiotics. As only 6 isoenzymes are responsible for approximately 90 % of known oxidative drug metabolism, a number of frequently prescribed drugs share the CYP-mediated metabolic pathways. Competing for a single enzyme by the co-administered therapeutic agents can substantially alter the plasma concentration and clearance of the agents. Furthermore, many drugs are known to inhibit certain p450 enzymes which they are not substrates for. Because some drug-drug interactions could cause serious adverse events leading to a costly failure of drug development, early detection of potential drug-drug interactions is highly desirable. The ultimate goal is to be able to predict the CYP specificity and the interactions for a novel compound from its chemical structure. Current computational modeling approaches, such as two-dimensional and three-dimensional quantitative structure-activity relationship (QSAR), pharmacophore mapping and machine learning methods have resulted in statistically valid predictions. Homology models have been often combined with 3D-QSAR models to impose additional steric restrictions and/or to identify the interaction site on the proteins. This article summarizes the available models, methods, and key findings for CYP1A2, 2A6, 2C9, 2D6 and 3A4 isoenzymes.
An Internet of Things Platform for Real-World and Digital Objects (2012)

The vision of the Internet of Things (IoT) relies on the provisioning of real-world services, which are provided by smart objects that are directly related to the physical world. A structured, machine-processible approach to provision such real-world services is needed to make heterogeneous physical objects accessible on a large scale and to integrate them with the digital world. The incorporation of observation and measurement data obtained from the physical objects with the Web data, using information processing and knowledge engineering methods, enables the construction of intelligent and interconnected things. The current research mostly focuses on the communication and networking aspects between the devices that are used for sensing amd measurement of the real world objects. There is, however, relatively less effort concentrated on creating dynamic infrastructures to support integration of the data into the Web and provide unified access to such data on service and application levels. This paper presents a semantic modelling and linked data approach to create an information framework for IoT. The paper describes a platform to publish instances of the IoT related resources and entities and to link them to existing resources on the Web. The developed platform supports publication of extensible and interoperable descriptions in the form of linked data.
Fundamentals of Classical and Statistical Thermodynamics (2002)

Thermodynamic Laws, Symbols and Units Some Further Preliminary Aspects of Thermodynamics Zeroth Law, Thermal Equilibrium and Thermometry The First Law of Thermodynamics Some Consequences of the First Law Some Applications of the First Law The Second Law of Thermodynamics and the Concept of Entropy Some Further Applications of the Combined First and Second Laws The Third Law of Thermodynamics Free Energy and Applications of Thermodynamic Principles Free Energy and Chemical Equilibrium Fundamental Concepts of Statistical Mechanics Statistical Mechanics Applied to Classical Thermodynamics Phase Equilibria and Phase Transition Distribution Functions and Thermodynamics of Fermi-Dirac and Bose-Einstein Gases Heat Capacities of Solids and Gases Solutions to Exercises Appendices Index
Exertional Heatstroke: Early Recognition and Outcome With Aggressive Combined Cooling—a 12-Year Experience (2009)

Despite early recognition and aggressive combined cooling, exertional heatstroke remains associated with multiorgan dysfunction. However, our 7.1% in-hospital mortality rate was low compared to previous studies. Early diagnosis and prompt treatment are critical.
Multimodal Image Fusion in Ultrasound-Based Neuronavigation: Improving Overview and Interpretation by Integrating Preoperative MRI with Intraoperative 3D Ultrasound (2003)

Objective: We have investigated alternative ways to integrate intraoperative 3D ultrasound images and preoperative MR images in the same 3D scene for visualizing brain shift and improving overview and interpretation in ultrasound-based neuronavigation.Materials and Methods: A Multi-Modal Volume Visualizer (MMW) was developed that can read data exported from the SonoWand® neuronavigation system and reconstruct the spatial relationship between the volumes available at any given time during an operation, thus enabling the exploration of new ways to fuse pre-and intraoperative data for planning, guidance and therapy control. In addition, the mismatch between MRI volumes registered to the patient and intraoperative ultrasound acquired from the dura was qualified.Results: The results show that image fusion of intraoperative ultrasound images in combination with preoperative MRI will make perception of available information easier by providing updated (real-time) image information and an extended overview of the operating field during surgery. This approach will assess the degree of anatomical changes during surgery and give the surgeon an understanding of how identical structures are imaged using the different imaging modalities. The present study showed that in 50% of the cases there were indications of brain shift even before the surgical procedure had started.Conclusions: We believe that image fusion between intraoperative 3D ultrasound and preoperative MRI might improve the quality of the surgical procedure and hence also improve the patient outcome.
Social Context Affects Expression of Conditioned Taste Aversions During Grooming By Pine Voles: Implications for Animal Damage Control (1981)

This Article is brought to you for free and open access by the Wildlife Damage Management, Internet Center for at DigitalCommons@University of
Relationship of Obstetric Complications and Differences in Size of Brain Structures in Monozygotic Twin Pairs Discordant for Schizophrenia (2000)

Trauma at the time of labor and delivery and especially prolonged labor appear to be of importance for brain structure anomalies associated with schizophrenia.
Advances in Photorefractive Polymers: plastics for Holography and Optical Processing (1995)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. E. Moerner and N. Peyghambarian, "Advances in Photorefractive Polymers: plastics for Holography and Optical Processing," Optics & Photonics News 6(3), 24-29 (1995) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article