gebhart/patrepeval huggingface dataset:
An XACML Policy Generating Method Based on Policy View (2008)

Attribute Based Access Control (ABAC) is a promising access control model for pervasive computing. XACML is recognized as an effective ABAC policy description method that can exactly describe the semantics of a policy. However, the description of a XACML policy is complex and it is difficult for users to compose such a policy, which seriously embarrasses the application of XACML. Aiming at this problem, this paper presents an XACML policy generating method basing on a user-oriented ABAC policy view. On the basis of analyzing the XACML policy description language, the paper first establishes a policy description template composed of primary policy description elements of XACML, and then proposes an ABAC concept model called Access Control Cube (ACCube) and submits a comprehensible user-oriented policy view basing on the ACCube. The policy view and the XACML policy template provide an easy and effective way for users to define XACML policies. Users can describe their ABAC policies by creating the policy views, which can then be transformed into XACML policies. The transforming algorithm is given in the paper. According to the foregoing method, we develop a XACML policy generating tool named XACML Policy Builder. An example of using XACML Policy Builder for building XACML policy is also given.
Exact distribution functions of test length for sequential processors with discrete input data (1963)

In studies of sequential detection of radar signals, the parameter of primary interest is the length of the sequential test, denoted by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> . Since this test length is a random variable, moments and/or probability distribution functions of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> are desirable. A procedure is described in this communication for obtaining exact probability distribution functions <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P(n)</tex> and exact average values of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> , <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E(n)</tex> , when the input to the sequential processor is discrete radar data (radar data in quantized form). This procedure is based upon the representation of the sequential test as a Markov process. The results are quite general in that they apply to multilevel quantization of the data. However, the procedure appears especially attractive when the number of levels is small as is usually the case when dealing with discrete radar data. The procedure for determining exact distribution functions and average values of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> presented herein is compared with the Wald-Girshick approach for obtaining <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">P(n)</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E(n)</tex> , and the superiority of the former approach in computational convenience is indicated.
Purification and Properties of Guanosine Triphosphate Cyclohydrolase and a Stimulating Protein from Comamonas Sp. (ATCC 11299a) (1974)

GTP cyclohydrolase and a stimulating protein were purified from extracts of Comomonas sp.(ATCC 11299a).The enzyme, designated Fraction A, catalyzed the production of formic acid and a dihydropteridine (PLOWNAN, J., CONE, J. E., AND GUROFF, G. (19'74) J. Biol.Chem.249, 5559~5564) from GTP.No cofactors or metals were required for the reaction.Fraction A can exist in two molecular weight forms demonstrated during sucrose density gradient centrifugation at low (5 mM 'Iris) and high (50 mM Tris) ionic strength.The stimulating protein, designated Fraction B, stimulated the activity of Fraction A at high ionic strength.Magnesium ion was required for this stimulation.Highly purified GTP cyclohydrolase was obtained after affinity chromatography of Fraction A. The activity of the purified enzyme was influenced by: (a) the amount of enzyme protein present; (b) the ionic strength of the assay medium; and (c) the presence of the stimulatory protein plus MgC12.The above variables were shown to affect the basic kinetic values, K,,, and V,,,, of the reaction.Pteridine production in Comamonas sp.1 depends on the enzyme GTP cyclohydrolase: which catalyzes the conversion of GTP to formic acid and B-substituted pterins (1).We have previously reported on the partial purification of this enzyme and on an unusual pteridine product thought to be a cyclic phosphate derivative of neopterin (2).However, a detailed examination of the reaction properties and unequivocal identification of the pteridine product were prevented by the apparent lability of the enzyme during purification, and by the limited amount, of product obtained from incubation mixtures.Similar enzymes, involved in the synthesis of the pteridine por-1 The Tenth Edition of the American Type Culture Collection Catalog lists the organism as a Pseudomonks sp.Although originallv classified as a Pseudomonas SD.. the Eighth Edition of the Catkogue listed the organism as acornanon& sp.* We have adopted the nomenclature of Burg and Brown (1968) who described the purification and properties of the enzyme from Escherichia coli.
The Extracellular Glycosidases of Diplococcus pneumoniae. I. Purification and Properties of a Neuraminidase and a β-Galactosidase. Action on the α<sub>1</sub>-Acid Glycoprotein of Human Plasma<sup>*</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Extracellular Glycosidases of Diplococcus pneumoniae. I. Purification and Properties of a Neuraminidase and a β-Galactosidase. Action on the α1-Acid Glycoprotein of Human Plasma*R. Colin Hughes and Roger W. JeanlozCite this: Biochemistry 1964, 3, 10, 1535–1543Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://pubs.acs.org/doi/10.1021/bi00898a025https://doi.org/10.1021/bi00898a025research-articleACS PublicationsRequest reuse permissionsArticle Views117Altmetric-Citations187LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cytokines, nitric oxide synthesis and liver regeneration (1995)

During the prereplicative period of liver regeneration the changes in the levels of mRNA for tumour necrosis factor-alpha (TNF-alpha) and its receptors were nearly synchronous. The mRNA levels reached their maximum 1-3 h after operation and exceeded the values for intact animals about ten-fold. Lipopolysaccharide stimulation induced an increase in TNF-alpha and TNF receptor production comparable with that occurring during regeneration. Nitric oxide (NO) production in the regenerating liver was determined by electron paramagnetic resonance (EPR) spectroscopy. The first increase in NO production occurred approximately 1 h after partial hepatectomy (PHE). The second and more pronounced peak of NO production was observed about 6 h after PHE when the hepatocytes entered the first cell cycle; it originated mainly from these cells. The consequent minimum of NO synthesis coincided with the maximal rate of DNA synthesis. The third gradual rise of NO production was seen at the transit from the first to the second cell cycle of the hepatocytes and the entrance of the non-parenchymal cells into proliferation. Hepatocytes, Kupffer and endothelial cells were isolated from livers after PHE. They were found to start their main NO production in the described sequence at the times corresponding to their respective entrance into the cell cycle. The maxima of NO synthesis were inversely correlated to the DNA-synthesizing activity of the individual cell type.
Complex environment of nascent polypeptide chains. (1994)

Nascent polypeptides enter into high molecular weight complexes with other proteins during chain elongation in vitro and in vivo. The nature of these complexes was investigated using an in vitro translation system programmed with a single mRNA lacking a translational termination codon. Complexes containing nascent polypeptides (molecular mass < 20 kDa), the molecular chaperone hsp 73 and other unidentified proteins can be released from the translationally arrested polysomes by puromycin treatment. The apparent native molecular mass of the nascent chain binding complex was determined to be > 700 kDa by gel-filtration analysis. Complexes between the nascent polypeptide and at least hsp 73 appear to be sensitive to (disrupted by) ATP. The presence of ATP also dramatically alters the sensitivity of the nascent polypeptide chains to digestion by exogenous protease. Collectively, our data indicate that there may be a cytoplasmic machinery, including hsp 70, which comprises a nascent polypeptide chain binding complex.
A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study. (1992)

This trial demonstrated that IDR was more effective than DNR in remission induction in AML.
<i>Porphyromonas gingivalis</i> Fimbriae Bind to Cytokeratin of Epithelial Cells (2002)

The adherence of Porphyromonas gingivalis to host cells is likely a prerequisite step in the pathogenesis of P. gingivalis-induced periodontal disease. P. gingivalis binds to and invades epithelial cells, and fimbriae are shown to be involved in this process. Little is known regarding epithelial receptor(s) involved in binding of P. gingivalis fimbriae. Using an overlay assay with purified P. gingivalis fimbriae as a probe, two major epithelial cell proteins with masses of 50 and 40 kDa were identified by immunoblotting with fimbria-specific antibodies. Iodinated purified fimbriae also bound to the same two epithelial cell proteins. An affinity chromatography technique was utilized to isolate and purify the epithelial components to which P. gingivalis fimbriae bind. Purified fimbriae were coupled to CNBr-activated Sepharose-4B, and the solubilized epithelial cell extract proteins bound to the immobilized fimbriae were isolated from the column. A major 50-kDa component and a minor 40-kDa component were purified and could be digested with trypsin, suggesting that they were proteins. These affinity-eluted 50- and 40-kDa proteins were then subjected to amino-terminal sequencing, and no sequence could be determined, suggesting that these proteins have blocked amino-terminal residues. CNBr digestion of the 50-kDa component resulted in an internal sequence homologous to that of Keratin I molecules. Further evidence that P. gingivalis fimbriae bind to cytokeratin molecule(s) comes from studies showing that multicytokeratin rabbit polyclonal antibodies cross-react with the affinity-purified 50-kDa epithelial cell surface component. Also, binding of purified P. gingivalis fimbriae to epithelial components can be inhibited in an overlay assay by multicytokeratin rabbit polyclonal antibodies. Furthermore, we showed that biotinylated purified fimbriae bind to purified human epidermal keratin in an overlay assay. These studies suggest that the surface-accessible epithelial cytokeratins may act as receptor(s) for P. gingivalis fimbriae. We hypothesize that adherence of P. gingivalis fimbriae to cytokeratin may be important for colonization of oral mucous membranes and possibly also for activation of epithelial cells.
Eye on the spy: privacy laws (2017)

Privacy laws are finally catching up with technology in the workplace writes Charles Power. Copyright 2008 Charles Power. No part of this article may be reproduced by any means without the written consent of the publisher.
Surface aging mechanisms of AC plasma display panels (1975)

Excellent life performance is being achieved for ac plasma display panels through understanding of the causes of voltage changes, surface overcoat material research, and adjustment of the manufacturing process to eliminate contaminants. It has been found that surface aging phenomena are dominant in many practical cases. Because of prefereutial operation patterns (i.e., alpha numerics), a differential aging pattern may evolve. The differential pattern is the result of voltage changes which are different for heavily operated and lightly or nonoperated cells. It is shown that the nature and extent of surface changes are dependent on overcoat material selection and the presence (or absence) of contaminants introduced during manufacture. With the use of thin overcoat layers in contact with the gas, it is necessary to be aware of the possibility of surface film removal by sputtering. The effects of significant variables: gas pressure and composition surface material, and operating voltage are discussed.
Visualization of irregular multivariate data (1990)

The authors discuss effective techniques for representing scalar and vector valued functions that interpolate to irregularly located data. Special attention is given to the situations where the sampling domain is a two-dimensional plane, 3-D volume, or a closed 3-D surface. The authors first discuss the multiquadric and thin-plate spline methods for interpolating scalar data sampled at arbitrary locations in a plane. Straightforward generalizations are then made to data sampled in 3-D volumetric regions as well as in higher dimensional spaces. The globally defined interpolants can be evaluated on a fine regular grid and they can then be visualized using conventional techniques. Triangular and tetrahedral based visualization techniques are also presented. >
Evaluation of myocardial perfusion abnormalities with gadolinium-enhanced snapshot MR imaging in humans. Work in progress. (1992)

To determine whether myocardial perfusion abnormalities could be detected in patients with coronary artery disease by means of contrast material-enhanced magnetic resonance (MR) images, a snapshot imaging technique was used in six patients with coronary artery disease and four healthy subjects in conjunction with pharmacologic stress (dipyridamole infusion) and bolus injection of gadopentetate dimeglumine. MR images from all patients and healthy subjects were quantitatively analyzed to define spatial changes in signal intensity after administration of dipyridamole and gadopentetate dimeglumine. The resultant findings were compared with findings on thallium-201 scintigrams obtained after administration of dipyridamole and on coronary arteriograms in all patients. Nine myocardial regions supplied by stenosed arteries showed diminished levels of signal intensity after infusion of the contrast agent compared with those of normally perfused regions. These findings were in agreement with those obtained with T1-201 scintigraphy (in eight of nine regions) and arteriography. Thus, contrast-enhanced high-speed MR imaging with use of dipyridamole enabled detection of regional perfusion abnormalities in humans.
Relation Between the Conditions of Preparation and the Polarization Characteristics of Spongy Raney Nickel Electrodes Used as Anodes for Fuel Cells (1992)

Relation Between the Conditions of Preparation and the Polarization Characteristics of Spongy Raney Nickel Electrodes Used as Anodes for Fuel Cells, Tomida, Tahei, Okamura, Kazuhiro, Ashida, Toshifumi, Nakabayashi, Ichiro
THE DEFENSE OF ATHEISM (2014)

Reginald Williams in ‘The Case Against Theism’ ( Think Autumn 2011) argued that the ‘empirically verifiable’ psychological need ‘to believe that good things exist when in fact they don't’ offers ‘the best reason anyone should expect’ for endorsing atheism over theism. My article outlines six objections to his thesis, questioning how empirically verifiable the evidence he adduces is, and pointing out various logical fallacies such as illicit use of generalizations and begging the question. It concludes that atheism needs defending on stronger grounds.
The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing (2011)

Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 cooperate to trim a vast variety of antigenic peptide precursors to generate mature epitopes for binding to major histocompatibility class I molecules. We report here the first structure of ERAP2 determined at 3.08 Å by X-ray crystallography. On the basis of residual electron density, a lysine residue has been modeled in the active site of the enzyme; thus, the structure corresponds to an enzyme-product complex. The overall domain organization is highly similar to that of the recently determined structure of ERAP1 in its closed conformation. A large internal cavity adjacent to the catalytic site can accommodate large peptide substrates. The ERAP2 structure provides a structural explanation for the different peptide N-terminal specificities between ERAP1 and ERAP2 and suggests that such differences extend throughout the whole peptide sequence. A noncrystallographic dimer observed may constitute a model for a proposed ERAP1-ERAP2 heterodimer. Overall, the structure helps explain how two homologous aminopeptidases cooperate to process a large variety of sequences, a key property of their biological role.
Critical Dimension and Image Placement Issues for Step and Flash Imprint Lithography Templates (2002)

Step and Flash Imprint Lithography (SFIL) is an attractive low-cost method for printing sub-100 nm geometries. Relative to other imprinting processes, SFIL has the advantage that the template is transparent thereby facilitating conventional overlay techniques. In addition, the imprint process is performed at low pressures and room temperature, which minimizes magnification and distortion errors. Since SFIL is a 1X lithography technique, the template masks will require very good layer-to-layer overlay accuracy for multiple level device fabrication. To fabricate a transparent SFIL template, processing techniques familiar to existing binary phase shift mask fabrication are utilized. However, in order to fabricate the sub-100 nm features necessary for SFIL templates, thinner resist and chromium are necessary. Initial resolution tests have resulted in features sizes down to ~20 nm with the non-chemically amplified resist, ZEP520. Template to template overlay of <15 nm (mean + 3σ) can be achieved if the template fabrication procedure consists of a single 1” template exposed in the center of a 6” × 6” × 0.25” quartz blank.
Microstructure and mechanical properties of Ti‐6Al‐4V produced by electron beam melting of pre‐alloyed powders (2009)

Purpose The purpose of this paper is the microstructural and mechanical characterization of a biomedical Ti‐6Al‐4V alloy produced by electron beam melting, and the study of the stability of the as‐built microstructure upon heat treatment. Design/methodology/approach Ti‐6Al‐4V alloy produced by electron beam melting has been mechanically characterized through tensile and fatigue testing. Its microstructure has been investigated by optical observation after etching and by X‐ray diffractometry analysis. The stability of the microstructure of the as‐built material has been deepened carrying out suitable heat treatments, after an analysis by dilatometry test. Findings The microstructure of a Ti‐6Al‐4V alloy produced by electron beam melting has a very fine and acicular morphology, because of the intrinsically high‐solidification rate of the process. This microstructure is very stable, and the traditional thermal treatments cannot modify it; the microstructure changes significantly only when an amount of strain is introduced in the material. However, the mechanical properties of the alloy produced by electron beam melting are good. Originality/value The paper provides evidence of the microstructural stability of the material produced by electron beam melting. Even if the microstructure of the as‐built material is not recommended by the specific ISO standard, the related mechanical properties are fully satisfactory. This is a significant indication from the point of view of the production of Ti‐6Al‐4V orthopaedic and dental prostheses by electron beam melting.
Identification and Characterization of a Novel Protein Interacting with Ral-binding Protein 1, a Putative Effector Protein of Ral (1998)

Ral-binding protein 1 (RalBP1) is a putative effector protein of Ral and exhibits a GTPase activating activity for Rac and CDC42. To clarify the function of RalBP1, we isolated a novel protein that interacts with RalBP1 by yeast two-hybrid screening and designated it POB1 (partner of RalBP1). POB1 consists of 521 amino acids, shares a homology with Eps15, which has been identified as an epidermal growth factor (EGF) receptor substrate, and has two proline-rich motifs. The POB1 mRNA was expressed in cerebrum, cerebellum, lung, kidney, and testis. POB1 interacted with RalBP1 in COS cells and the C-terminal region of POB1 was responsible for this interaction. The binding domain of RalBP1 to POB1 was distinct from its binding domain to Ral. Ral and POB1 simultaneously interacted with RalBP1 in COS cells. The binding of POB1 to RalBP1 did not affect the GTPase activating activity of RalBP1. Furthermore, POB1 bound to Grb2 but not to Nck or Crk. POB1 was tyrosine-phosphorylated in COS cells upon stimulation with EGF and made a complex with EGF receptor. These results suggest that RalBP1 makes a complex with POB1 and that this complex may provide a link between tyrosine kinase, Src homology 3 (SH3)-containing protein, and Ral.
Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes (2007)

The effect of interval, direction and rate of strain on mechanotransduction in neonatal rat cardiomyocytes is determined for focal adhesion kinase (Y397pFAK), extracellular signal-regulated kinase ERK1/2 (Thr(183)/Tyr(185)) and paxillin (pY31) and phosphorylation time courses to 10% strain assessed. Cells are non-responsive at 5 min but recover at 15 min (P<0.03) with FAK nuclear translocation by 30 min. Cyclic biaxial strain increased phosphorylation from slower to faster rates (P<0.05). Uniaxial strain to groove-aligned myocytes increased FAK and ERK1/2 phosphorylation transversely more than longitudinally (P<0.05). Mechanotransduction may have a refractory period of 5 min and differentiate directions and rates of strain.