gebhart/patrepeval huggingface dataset:
Excess noise in thin film grain boundary Josephson junctions and devices (1996)

The subject of electronic noise in high- superconducting Josephson devices and in their applications is considered. Several types of grain boundary junctions, prepared in different ways by four separate international laboratories, are fully characterized in terms of their electrical and noise properties at a range of temperatures, frequencies, magnetic fields and in the presence of microwaves. Similar characterization is carried out for multijunction Josephson flux-flow arrays, and bi-epitaxial SQUIDs.
HDAC Inhibitors as Novel Anti-Cancer Therapeutics (2015)

Malignant growth of cells is a condition characterized by unchecked cellular proliferation, genetic instability and epigenetic dysregulation. Up-regulated HDAC (Histone Deacetylase) enzyme activity is associated with a closed chromatin assembly and subsequent gene repression, forming a characteristic feature of malignantly transformed cells. Novel therapeutics are now targeting the zinc containing HDAC enzymes for treating various types of cancers. Recently, a spate of drugs acting via HDAC inhibition have been undergoing clinical trials and several patents present exciting molecules like PCI-24781 (Abexinostat), ITF- 2357 (Givinostat); MS-275 (Entinostat), MGCD 0103 (Mocetinostat), LBH-589 (Panobinostat), FK228 (Romidepsin), PXD-101 (Belinostat) and Valproic Acid to be used as alternatives or adjuvants to traditional chemotherapeutics. However, only three HDAC inhibitors have acquired FDA approval till date. Recently, PXD-101 obtained FDA approval for the treatment of Refractory or Relapsed Peripheral T cell lymphoma. The current article reviews patents that have introduced novel molecules that are HDAC isoform specific, superior to first generation HDAC inhibitors like SAHA (Suberoylanilide Hydroxamic Acid) and TSA (Trichostatin A) and can be modified structurally to reduce toxic side effects and increase specificity. These molecules can combine the best characteristics of an ideal HDAC inhibiting drug either as monotherapy or in combinatorial therapy for cancer treatment thus, indicating promise to be included in the next generation of target specific HDAC inhibiting drugs.
Trusted virtual domains: toward secure distributed services (2005)

The focus of trusted computing efforts to date has been to create islands of trust in a sea of distrust, identifying these islands as dependable domains with a solid base that can be used for building applications upon which critical services depend. The aim of our work is to extend this solid base by building “bridges ” among trusted islands, with such goals as enabling meaningful trade agreements between islands, enabling migration of individual island inhabitants, and enabling geography-independent affiliation among inhabitants of different islands.
A Novel Indirect Wollastonite Carbonation Route for CO<sub>2</sub> Sequestration (2010)

Abstract A new CO 2 sequestration approach through indirect wollastonite carbonation is proposed to mitigate anthropogenic CO 2 emissions from fossil fuel combustion. The wollastonite carbonation process includes three steps: (1) dissolution of wollastonite in hydrochloric acid to leach Ca 2+ from mineral matrix; (2) reaction of the resulting CaCl 2 solution with CO 2 in triisooctylamine (TIOA) at low temperature, producing CaCO 3 and an amino acid complex; (3) regeneration of the extractant and acid by backextraction through a temperature swing process and recycling to the dissolution and carbonation steps. It was found that the wollastonite dissolution rate was accelerated by hydrochloric acid and a maximum Ca 2+ dissolution extent of 95 % was obtained.
Common Standards of Basal Insulin Titration in T2DM (2013)

Type 2 diabetes mellitus has become a worldwide major health problem, and the number of people affected is steadily increasing. Thus, not all patients suffering from the disease can be treated by specialized diabetes centers or outpatient clinics, but by primary care physicians. The latter, however, might have time constraints and have to deal with many kinds of diseases or with multimorbid patients, so their focus is not so much on lowering high blood glucose values. Thus, the physicians, as well as the patients themselves, are often reluctant to initiate and adjust insulin therapy, although basal insulin therapy is considered the appropriate strategy after oral antidiabetic drug failure, according to the latest international guidelines. A substantial number of clinical studies have shown that insulin initiation and optimization can be managed successfully by using titration algorithms-even in cases where patients themselves are the drivers of insulin titration. Nevertheless, tools and strategies are needed to facilitate this process in the daily life of both primary health care professionals and patients with diabetes.
Les chefs, une question pour l'histoire du XXe siècle (2001)

Le nazisme organise tout pouvoir au sein du IIIe Reich selon le Fuhrerprinzip, le principe du chef. L'historien americain Robert Paxton a pu donner du fascisme une definition qui le presente d'abord comme un « systeme d'autorite et d'encadrement »' Lorsque l'Union sovietique s'est effondree, l'expression de « systeme de commandement administratif» a largement prevalu, en Russie mais aussi ailleurs, pour designer le regime qui disparaissait. Il s'en faut que la question du commandement n'ait ete centrale, au cours du siecle passe, que pour les regimes fascistes et communistes. C'est par exemple le chef de la France libre qui se dresse en 1940 contre celui qui s'est fait accorder le titre de chef de l'Etat francais. L'ideal du chef, l'obsession du chef etaient presents simultanement, dans les annees 1930 et 1940, sous des formes extremement differentes dans les pays les plus varies mais, s'ils ont connu durant cette periode leur apogee, ils se sont constitues bien anterieurement comme phenomene historique 67
Mixed Reality Remote Collaboration Combining 360 Video and 3D Reconstruction (2019)

Remote Collaboration using Virtual Reality (VR) and Augmented Reality (AR) has recently become a popular way for people from different places to work together. Local workers can collaborate with remote helpers by sharing 360-degree live video or 3D virtual reconstruction of their surroundings. However, each of these techniques has benefits and drawbacks. In this paper we explore mixing 360 video and 3D reconstruction together for remote collaboration, by preserving benefits of both systems while reducing drawbacks of each. We developed a hybrid prototype and conducted user study to compare benefits and problems of using 360 or 3D alone to clarify the needs for mixing the two, and also to evaluate the prototype system. We found participants performed significantly better on collaborative search tasks in 360 and felt higher social presence, yet 3D also showed potential to complement. Participant feedback collected after trying our hybrid system provided directions for improvement.
Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice (2010)

Airway macrophages provide a first line of host defense against a range of airborne pathogens, including influenza virus. In this study, we show that influenza viruses differ markedly in their abilities to infect murine macrophages in vitro and that infection of macrophages is nonproductive and no infectious virus is released. Virus strain BJx109 (H3N2) infected macrophages with high efficiency and was associated with mild disease following intranasal infection of mice. In contrast, virus strain PR8 (H1N1) was poor in its ability to infect macrophages and highly virulent for mice. Depletion of airway macrophages by clodronate-loaded liposomes led to the development of severe viral pneumonia in BJx109-infected mice but did not modulate disease severity in PR8-infected mice. The severe disease observed in macrophage-depleted mice infected with BJx109 was associated with exacerbated virus replication in the airways, leading to severe airway inflammation, pulmonary edema, and vascular leakage, indicative of lung injury. Thymic atrophy, lymphopenia, and dysregulated cytokine and chemokine production were additional systemic manifestations associated with severe disease. Thus, airway macrophages play a critical role in limiting lung injury and associated disease caused by BJx109. Furthermore, the inability of PR8 to infect airway macrophages may be a critical factor contributing to its virulence for mice.
Auditory and tactile interfaces for representing the visual effects on the web (2002)

In this paper, we describe auditory and tactile interfaces to represent visual effects nonvisually for blind users, allowing intuitive recognition of visual content that appears on the Web. This research examines how visual effects could be recognized by blind subjects using the senses of hearing and touch, aiming at integrating the results into a practical system in the future. As an initial step, two experiments were performed, one for sonification and tactilization of a page overview based on color-based fragmented groupings without speech, and one for sonification and tactilization of emphasized text based on analyzing rich text information with speech. The subjects could recognize visual representations presented by auditory and tactile interfaces throughout the experiment, and were conscious of the importance of the visual structures. We believe this shows our approach may be practical and available in the future.We will summarize our results and discuss what kind of information is suitable for each sense, as well as the next planned experiment and other future work.
Hash-based IP traceback (2001)

The design of the IP protocol makes it difficult to reliably identify the originator of an IP packet. Even in the absence of any deliberate attempt to disguise a packet's origin, wide-spread packet forwarding techniques such as NAT and encapsulation may obscure the packet's true source. Techniques have been developed to determine the source of large packet flows, but, to date, no system has been presented to track individual packets in an efficient, scalable fashion.We present a hash-based technique for IP traceback that generates audit trails for traffic within the network, and can trace the origin of a single IP packet delivered by the network in the recent past. We demonstrate that the system is effective, space-efficient (requiring approximately 0.5% of the link capacity per unit time in storage), and implementable in current or next-generation routing hardware. We present both analytic and simulation results showing the system's effectiveness.
Physical-Layer-Aware MAC Schemes for Dynamic Subcarrier Assignment in OFDMA-PON Networks (2012)

In this paper, a medium access control (MAC) framework tailored for orthogonal frequency-division multiple access passive optical networks (OFDMA-PONs) is defined which allows exploiting both the subcarrier and time domains in a dynamic and flexible way. A dynamic subcarrier assignment algorithm that respects quality of service by offering decreased average delay is proposed. Moreover, effective methods to improve its performance and reduce its complexity are provided. Additionally, the proposed PON MAC framework for the first time leverages on a cross-layer optimization via adaptive quadrature amplitude modulation (QAM) per optical network unit (ONU). The performance of all schemes is evaluated using computer simulations.
Characterization of Mycoplasma Arginine Deiminase Expressed in E. coli and Its Inhibitory Regulation of Nitric Oxide Synthesis (2002)

We previously reported that a cytostatic protein that is found in ASC-17D Sertoli cell-conditioned media was Mycoplasma arginine deiminase (ADI), which hydrolyzes L-arginine into L-citrulline and ammonia. Here, we report the over-expression of recombinant ADI (rADI) in E. coli and the down-regulation of lipopolysaccharide (LPS) induced-nitric oxide (NO) production by rADI treatment. We cloned the ADI gene from Mycoplasma arginini genomic DNA by a polymerase chain reaction, and changed five TGA tryptophan codons (stop codon in E. coli) to TGG codons in the coding region by site-directed mutagenesis in order to express in E. coli. The rADI was purified to apparent homogeneity by DEAE-Sepharose and arginine-affinity chromatography. The rADI expressed in E. coli was identified as 45 kDa on SDS-PAGE and 90 kDa on native PAGE, implying that it exists as a dimer like ADI of M. arginini. The Km for arginine of rADI was approximately 370+/-50 microM. Its optimal temperature and pH were 41 degrees C and pH 6.4, respectively, and enzyme activity remained > or = 50% for 5 d at physiological temperature and pH. Treatment of purified rADI suppressed NO production in macrophage-like RAW 264.7 and primary glial cells that were exposed to LPS. Furthermore, an intraperitoneal injection of rADI significantly suppressed the rise of blood nitrite/nitrate levels that were induced by the systemic administration of bacterial endotoxin LPS to mice, resulting in an improvement in their survival rate. These results suggest that the depletion of blood arginine with an arginine-metabolizing enzyme, such as ADI, could suppress excessive production of NO that is caused by inducible NOS (iNOS) during the endotoxemia. Also, rADI may be used as a new approach to control NO-related diseases, such as sepsis.
Trophoblast-Derived Interleukin-6 (IL-6) Regulates Human Chorionic Gonadotropin Release through IL-6 Receptor on Human Trophoblasts* (1990)

We examined the capacity of trophoblast-derived interleukin-6 (IL-6) to stimulate secretion of placental hormones, including hCG. IL-6 stimulated hCG secretion by trophoblasts to a level similar to that stimulated by a GnRH analog. The analog, however, released hCG by an IL-6-independent mechanism because PM-1, a monoclonal antibody specific for IL-6 receptors (R), failed to block GnRH-mediated responses, but completely blocked IL-6-mediated hCG secretion, suggesting the existence of two distinct regulatory pathways for hCG release. Immunohistochemical analysis with another IL-6-R-specific antibody, MT-18, showed that IL-6-R was located only on the trophoblast layer of the placenta. Our data revealed the existence of a local regulatory network by which trophoblast-derived IL-6 interacts with IL-6-R on the trophoblasts, resulting in hCG release. Thus, two different regulatory networks, an IL-6 and IL-6-R system and a GnRH and GnRH-R system, regulate hCG release by human trophoblasts independently.
Real-Time Recognition and Profiling of Appliances through a Single Electricity Sensor (2010)

Sensing, monitoring and actuating systems are expected to play a key role in reducing buildings overall energy consumption. Leveraging sensor systems to support energy efficiency in buildings poses novel research challenges in monitoring space usage, controlling devices, interfacing with smart energy meters and communicating with the energy grid. In the attempt of reducing electricity consumption in buildings, identifying individual sources of energy consumption is key to generate energy awareness and improve efficiency of available energy resources usage. Previous work studied several non-intrusive load monitoring techniques to classify appliances; however, the literature lacks of an comprehensive system that can be easily installed in existing buildings to empower users profiling, benchmarking and recognizing loads in real-time. This has been a major reason holding back the practice adoption of load monitoring techniques. In this paper we present RECAP: RECognition of electrical Appliances and Profiling in real-time. RECAP uses a single wireless energy monitoring sensor easily clipped to the main electrical unit. The energy monitoring unit transmits energy data wirelessly to a local machine for data processing and storage. The RECAP system consists of three parts: (1) Guiding the user for profiling electrical appliances within premises and generating a database of unique appliance signatures; (2) Using those signatures to train an artificial neural network that is then employed to recognize appliance activities (3) Providing a Load descriptor to allow peer appliance benchmarking. RECAP addresses the need of an integrated and intuitive tool to empower building owners with energy awareness. Enabling real-time appliance recognition is a stepping-stone towards reducing energy consumption and allowing a number of major applications including load-shifting techniques, energy expenditure breakdown per appliance, detection of power hungry and faulty appliances, and recognition of occupant activity. This paper describes the system design and performance evaluation in domestic environment.
Nondepressant .beta.-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols (1978)

A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for beta-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12--15 were found to retain the beta-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.
Extraction and partial characterization of surfactant-soluble antigens from adult female Dirofilaria immitis. (1985)

Antigens were solubilized from aqueous-insoluble material of adult female Dirofilaria immitis with Triton X-100 and sodium dodecyl sulfate (SDS) and partially characterized. Concentrations of 2.1-8.3 mg Triton X-100/mg total protein and 1.06-4.26 mg SDS/mg total protein were used to solubilize antigens. Triton X-100 was more efficient in solubilizing protein than SDS; Triton X-100 and SDS released 75% and 26% of the available protein, respectively. Protein mixtures solubilized with different levels of Triton X-100 appeared to be identical in immunodiffusion. Crossed immunoelectrophoresis revealed six antigen systems. Triton X-100 solubilized antigens did not react in immunodiffusion with sera from 7 D. immitis-infected, microfilaremic dogs, but did react with sera from 4 of 5 dogs with occult D. immitis infections.
Technetium-99m labeling of DNA oligonucleotides. (1995)

Amino-modified, single-stranded DNA can be stably radiolabeled with 99mTc by the SHNH moiety without loss of function.
<title>Hierarchical storage and visualization of real-time 3D data</title> (2001)

In this paper 'real-time 3D data' refers to volumetric data that are acquired and used as they are produced. Large scale, real-time data are difficult to store and analyze, either visually or by some other means, within the time frames required. Yet this is often quite important to do when decision-makers must receive and quickly act on new information. An example is weather forecasting, where forecasters must act on information received on severe storm development and movement. To meet the real-time requirements crude heuristics are often used to gather information from the original data. This is in spite of the fact that better and better real-time data are becoming available, the full use of which could significantly improve decisions. The work reported here addresses these issues by providing comprehensive data acquisition, analysis, and storage components with time budgets for the data management of each component. These components are put into a global geospatial hierarchical structure. The volumetric data are placed into this global structure, and it is shown how levels of detail can be derived and used within this structure. A volumetric visualization procedure is developed that conforms to the hierarchical structure and uses the levels of detail. These general methods are focused on the specific case of the VGIS global hierarchical structure and rendering system,. The real-time data considered are from collections of time- dependent 3D Doppler radars although the methods described here apply more generally to time-dependent volumetric data. This paper reports on the design and construction of the above hierarchical structures and volumetric visualizations. It also reports result for the specific application of 3D Doppler radar displayed over photo textured terrain height fields. Results are presented results for the specific application of 3D Doppler radar displayed over photo textured terrain height fields. Results are presented for display of time-dependent fields as the user visually navigates and explores the geospatial database.
[Research progress in genetic engineering of plant secondary metabolism]. (2005)

Secondary metabolism plays an important role in plant life as well as the interaction between plants and environmental factors. Many secondary metabolites derived from plants have been used for the production of medicines, dyes, insecticides, food flavors, fragrances and so on. With increasingly comprehensive understanding of the plant metabolic networks, great progress has been made in the genetic improvement of plant secondary metabolic pathways through gene engineering. Strategies for the genetic engineering of plant secondary metabolism include: (1) enabling the host plant to accumulate a novel desirable compound by transformation of single/multiple enzyme gene (s) or a whole metabolic pathway; (2) decreasing target gene expression or inhibiting competitive metabolic pathway to achieve metabolic flux towards higher production of particular molecules through antisense RNA and RNA interference technologies; (3) effectively manipulating the transcription factors responsible for the metabolic regulation at multiple steps in a given pathway so as to have a great synthesis of the target bio-chemicals. Basing on author's research work on flavonoid synthesis mechanism in soybean seed and its gene engineering, recent progress in the engineering of plant secondary metabolism involved in the synthesis of anthocyanins, flavonoids, alkaloids, terpenoids, benzoic acid derivatives etc are reviewed.
An internetwork memo distribution capability---MMDF (1979)

The advent of packet-switched networks has led to increased use of computers for sending text messages (memos) between people. However, attachment to common carrier or equivalent packet networks is expensive and/or restricted by organizational policies. In addition, use of several networks creates the need for relaying memos between them. The work described here is designed to free users from dependence upon any particular communication environment and to provide a memo distribution facility which can employ whatever communication channels are available. It will support variable-network structures, emulation of network attachment, and inter-network memo forwarding.
Robust designs through design to six sigma manufacturability (2002)

This paper describes the approach Hughes Aircraft Company is using to integrate six sigma and robust design approaches on major quality management programs. Six sigma and robust design techniques must be tightly coupled to ensure that a design is both manufacturable and also serves the needs of the customer. Because of the need to ensure customer satisfaction early in the design life cycle, Hughes Aircraft Company has made the development and deployment of six sigma and robust design a top priority. This paper describes how Hughes is linking six sigma and robust design to ensure customer satisfaction.