gebhart/patrepeval huggingface dataset:
IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis (2016)

This study introduces a flexible format for tolerogenic vaccination that incorporates IFN-β and neuroantigen (NAg) in the Alum adjuvant. Tolerogenic vaccination required all three components, IFN-β, NAg, and Alum, for inhibition of experimental autoimmune encephalomyelitis (EAE) and induction of tolerance. Vaccination with IFN-β + NAg in Alum ameliorated NAg-specific sensitization and inhibited EAE in C57BL/6 mice in pretreatment and therapeutic regimens. Tolerance induction was specific for the tolerogenic vaccine Ag PLP178-191 or myelin oligodendrocyte glycoprotein (MOG)35-55 in proteolipid protein- and MOG-induced models of EAE, respectively, and was abrogated by pretreatment with a depleting anti-CD25 mAb. IFN-β/Alum-based vaccination exhibited hallmarks of infectious tolerance, because IFN-β + OVA in Alum-specific vaccination inhibited EAE elicited by OVA + MOG in CFA but not EAE elicited by MOG in CFA. IFN-β + NAg in Alum vaccination elicited elevated numbers and percentages of FOXP3<sup>+</sup> T cells in blood and secondary lymphoid organs in 2D2 MOG-specific transgenic mice, and repeated boosters facilitated generation of activated CD44<sup>high</sup> CD25<sup>+</sup> regulatory T cell (Treg) populations. IFN-β and MOG35-55 elicited suppressive FOXP3<sup>+</sup> Tregs in vitro in the absence of Alum via a mechanism that was neutralized by anti-TGF-β and that resulted in the induction of an effector CD69<sup>+</sup> CTLA-4<sup>+</sup> IFNAR<sup>+</sup> FOXP3<sup>+</sup> Treg subset. In vitro IFN-β + MOG-induced Tregs inhibited EAE when transferred into actively challenged recipients. Unlike IFN-β + NAg in Alum vaccines, vaccination with TGF-β + MOG35-55 in Alum did not increase Treg percentages in vivo. Overall, this study indicates that IFN-β + NAg in Alum vaccination elicits NAg-specific, suppressive CD25<sup>+</sup> Tregs that inhibit CNS autoimmune disease. Thus, IFN-β has the activity spectrum that drives selective responses of suppressive FOXP3<sup>+</sup> Tregs.
Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases (2017)

Advanced glycation end products (AGEs) and their receptor have been implicated in the progressions of many intractable diseases, such as diabetes and atherosclerosis, and are also critical for pathologic changes in chronic degenerative diseases, such as Alzheimer's disease, Parkinson's disease, and alcoholic brain damage. Recently activated macrophages were found to be a source of AGEs, and the most abundant form of AGEs, AGE-albumin excreted by macrophages has been implicated in these diseases and to act through common pathways. AGEs inhibition has been shown to prevent the pathogenesis of AGEs-related diseases in human, and therapeutic advances have resulted in several agents that prevent their adverse effects. Recently, anti-inflammatory molecules that inhibit AGEs have been shown to be good candidates for ameliorating diabetic complications as well as degenerative diseases. This review was undertaken to present, discuss, and clarify current understanding regarding AGEs formation in association with macrophages, different diseases, therapeutic and diagnostic strategy and links with RAGE inhibition.
Open-Flow Microperfusion of Subcutaneous Adipose Tissue for On-Line Continuous Ex Vivo Measurement of Glucose Concentration (1997)

By combining open-flow microperfusion, glucose sensor, and conductivity measurement, glucose concentration in the subcutaneous adipose tissue can be monitored on-line, extracorporeally, and continuously without any in vivo calibration, and gives accurate measurements during hyper- and hypoglycemia.
Diaryl disulfide solves sulfur-deposition problems at sour gas field (1991)

This paper reports on use of diaryl disulfide (DADS) sulfur solvent which was successful in removing sulfur from tubulars and flow lines at Exxon Co. USA's LaBarge field in Wyoming. Additionally, the company's experience indicates that sulfur deposition can be a concern for gases with {lt}5% H{sub 2}S and that phase behavior and well bore hydraulic models can be used to predict where, and how much, sulfur can be expected to be deposited. Deposition of elemental sulfur in tubulars and flow lines can lead to decreased production, increased corrosion, and higher filtration-water disposal costs. These problems have been seen at LaBarge field even though its 5% H{sub 2}S concentration is below a level at which sulfur deposition is normally a concern. In its LaBarge application, Exxon found DADS to be preferable for sulfur-deposition problems because it was cheaper, less volatile, and easier to regenerate with no disposal needed when compared with the more commonly used solvent, dimethyl disulfide (DMDS).
Changes in metabolic rate and N excretion in the marine invertebrate<i>Sipunculus nudus</i>under conditions of environmental hypercapnia (2002)

Increased CO(2) partial pressures (hypercapnia) as well as hypoxia are natural features of marine environments like the intertidal zone. Nevertheless little is known about the specific effects of CO(2) on metabolism, except for the well-described effects on acid-base variables and regulation. Accordingly, the sediment-dwelling worm Sipunculus nudus was used as an experimental model to investigate the correlation of acid-base-induced metabolic depression and protein/amino acid catabolism, by determining the rates of oxygen consumption, ammonia excretion and O/N ratios in non-perfused preparations of body wall musculature at various levels of extra- and intracellular pH, P(CO(2)) and [HCO(3)(-)]. A decrease in extracellular pH from control level (7.9) to 6.7 caused a reduction in aerobic metabolic rate of both normocapnic and hypercapnic tissues by 40-45 %. O/N ratios of 4.0-4.5 under control conditions indicate that amino acid catabolism meets the largest fraction of aerobic energy demand. A significant 10-15 % drop in ammonia excretion, a simultaneous reduction of O/N ratios and a transient accumulation of intracellular bicarbonate during transition to extreme acidosis suggest a reduction in net amino acid catabolism and a shift in the selection of amino acids used, favouring monoamino dicarboxylic acids and their amines (asparagine, glutamine, aspartic and glutamic acids). A drop in intracellular pH was identified as mediating this effect. In conclusion, the present data provide evidence for a regulatory role of intracellular pH in the selection of amino acids used by catabolism.
Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms (2010)

In a comparison of VR, petrolatum, and no treatment, parents rated VR most favorably for symptomatic relief of their child's nocturnal cough, congestion, and sleep difficulty caused by upper respiratory tract infection. Despite mild irritant adverse effects, VR provided symptomatic relief for children and allowed them and their parents to have a more restful night than those in the other study groups.
Test de Raven, baremos argentinos para el rango 19-30 años y efecto Flynn (2020)

This article aims to show the final results of the research project devoted to build norms for Raven’s Standard Progressive Matrices (Raven, Raven, & Court, 2003), on subjects aged 19 to 30 years old in the city of La Plata, Argentina. The sample consisted of 979 subjects of both sexes, and was divided into four age groups. The results show that as the participant’s age increases, the average group’s performance improves, and variability remains similar between groups. There were no statistically significant differences found between sexes, or between the current results and those from the 2000 norms. It was found that the scores’ increase, expected according to the Flynn effect, has stopped, and the possible intergenerational cognitive differences which could explain this phenomenon are discussed. These results are also compared with those from recent research made in other countries.
Droplet on demand system utilizing a computer controlled microvalve integrated into a stiff polymeric microfluidic device (2009)

An integrated microvalve fabricated in a stiff polymeric (polycarbonate) device allows for formation of droplets and bubbles of arbitrary volumes and at arbitrary times of emission. Predesigned protocols of formation of sequences of volumes, intervals between the droplets and their chemical compositions can be practically and reproducibly realised and controlled from a personal computer. The design of the microvalve enables its utilization in chips made in a range of other materials, including plastics and glass and in devices operated both with positive and negative pressure providing a useful module for a range of applications of microfluidic droplet systems.
Mercury barometers and manometers (1960)

Preparation of this Monograph on mercury barometers and manometers was undertaken to fill the need of manufacturers and users for information which is now scattered thi-ough the literature and im some cases unpublished.
Depsipeptide analogues of elastin repeating sequences: Synthesis (1990)

Depsipeptide analogues of peptide sequences can help in elucidating the role of specific hydrogen bonds in determining the conformation in peptides. The repeating pentapeptide and hexapeptide sequences of elastin have been suggested to contain a type II beta-turn with a 4----1 hydrogen bond. Depsipeptide analogues of the repeating sequences of elastin in which this 4----1 hydrogen bond cannot exist were synthesized. A fragment condensation approach was employed in which the depsipeptide ester bond was introduced early in the synthesis. This approach proved to be effective, although the increased lability of the depsipeptide ester bond resulted in side products and low yields in some reactions.
Radial arm saw techniques (1986)

Both a user's and a buyer's guide! Covers every model and takes you through every operation -- showing all the latest attachments, accessories, techniques and much more! Special troubleshooting secrets.
New Systems for Laser Cladding (2013)

Abstract Components used in the manufacture of steel strip work in exceptionally aggressive environments and have to withstand service at high temperatures in corrosive atmospheres under mechanical wear and frequent and heavy impact loading. Conventionally, components that are subject to high wear or corrosion have often been manufactured from rich chemistry steels or hardfaced using submerged arc clad martensitic stainless steels to increase their campaign life and therefore maximise line throughput by extending maintenance intervals without any sacrifice to product quality.
Transoral approach to the upper cervical spine (1991)

The transoral approach to pathology of the upper cervical spine is logical, but it is seldom used due to concerns about exposure and infection. The authors report on 16 consecutive patients requiring exposure from clivus through C3 for pathology, including spinal cord compression by rheumatoid pannus, craniovertebral anomalies, and tumor. Exposure was obtained using a Dingman mouth gag and soft palate retraction with silicone rubber sheeting. A horizontal "H" incision was made in the posterior pharyngeal wall creating three layers, closed separately, with attention to a watertight closure of the final mucosal layer. In no case was it necessary to divide the mandible, tongue, soft palate, or uvula. There were no deaths, wound breakdowns, infections, or persistent cerebrospinal fluid leakage. Patients with neurological indications improved postoperatively, and all tumors were grossly resected. Combined otolaryngology/neurosurgical exposure and treatment of pathology involving the upper cervical spine via the transoral approach is safe and effective. Functional results have been excellent, and no major complications were encountered.
Capless annealing of ion-implanted GaAs (1976)

A method is reported for capless annealing of ion-implanted GaAs which gives electrical activation of Se-implanted wafers nearly identical to that obtained with sputtered silicon nitride caps. State-of-the-art performance has been realized from Schottky-gate FET’s fabricated from this material.
A comparative analysis of academic dissertation management systems in China (2010)

The paper is to do a comparative evaluation on the four major digital theses and dissertations management systems used in the mainland China,which are TRS,TPI,TASi and IDL-ETD.The evaluation analysis is primarily based on the systematic tests on these systems conducted by DUT(Dalian University of Technology)Library.Special focuses are on the distinctive features of each system such as their performance in terms of stability,reliability,openness,capacity of backdating,copyright protection,service monitoring,document conversion and release automation,log management,statistical tabulations,vendor’s technical support and so on.In addition,authors provide a statistics on the choice of academic dissertation system of most 985a)colleges and universities in China.
Spectrum Loading and Crack Growth (1972)

An analytical device for improving the accuracy of crack growth predictions in metal subjected to variable amplitude cyclic loading is presented. A modification to the linear cumulative growth idea is proposed which incorporates a consideration of prior load history by taking into account the yield zone ahead of the crack tip. Correlation between analysis and experimental results for six different cases shows that the scheme, even though only a first order improvement on the Miner idea, is sound and can be used with confidence for design and analysis.
Species composition in the CO&lt;inf&gt;2&lt;/inf&gt;discharge laser (1974)

The composition of a sealed discharge in He-N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and He-CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> mixtures was studied with a quadrupole mass spectrometer. A modulated molecular beam sampling technique allowed direct measurement of the molecular, atomic, and ionic species produced in the discharge. Effective formation and destruction rates were measured for various species. In particular, the nitrogen oxides, NO and NO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , are formed in sufficient quantities to affect the performance of CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> lasers. In the He-N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> mixture the dominant ion changes from CO- <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> to NO+, while in He-CO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , O+ <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> becomes the major ion.
A Computerised ELISA System for the Determination of Total and Antigen-Specific Immunoglobulins in Serum and Secretions (1981)

A computerized micro-ELISA system is described which features rapid and simple procedures for sample storage and transfer, plate washing and calculation of results. Calculations are performed by a Commodore Pet desk computer interfaced with a Titertek Multiskan micro-ELISA plate reader. Up to 1200 analyses per day can be performed by one person. Its application to the measurement of total immunoglobulin isotype and class specific antibody to parainfluenza type 1 (Sendai virus) in mice is described.
Evidence for an Ancestral Association of Human Coronavirus 229E with Bats (2015)

The ancestral origins of major human coronaviruses (HCoVs) likely involve bat hosts. Here, we provide conclusive genetic evidence for an evolutionary origin of the common cold virus HCoV-229E in hipposiderid bats by analyzing a large sample of African bats and characterizing several bat viruses on a full-genome level. Our evolutionary analyses show that animal and human viruses are genetically closely related, can exchange genetic material, and form a single viral species. We show that the putative host switches leading to the formation of HCoV-229E were accompanied by major genomic changes, including deletions in the viral spike glycoprotein gene and loss of an open reading frame. We reanalyze a previously described genetically related alpaca virus and discuss the role of camelids as potential intermediate hosts between bat and human viruses. The evolutionary history of HCoV-229E likely shares important characteristics with that of the recently emerged highly pathogenic Middle East respiratory syndrome (MERS) coronavirus.
Design and fabrication of Tri-Gated FinFET (2004)

A Tn Gated Fin Field Effect Transistor is on of the many novel devices that may be replacing planar MOSFETs, by reducing short channel effects. The FinFET has emerged as one of the most promising double gate structures primarily because of its ease of manufacturing. There are still significant challenges to overcome it in order to make the process available commercially. The Tri-Gated FinFET is tri-gated meaning that the gate overlaps the top and the two sides of the FIN. Three dimensionally the gate depletes three surfaces of the FIN, which results in a higher drive current relative to a planar MOSFET. In order to reduce current crowding in the Fin corners, we have curved the corners using oxide etch back process. FinFETs has been built previously at Rochester Institute of Technology. We have designed and fabricated Tri-Gated FinFETs of various geometries. Electrical test showed poor performance of the devices. Proper scrutiny of the electrical results and the SEM micrographs allowed us to conclude that if LTO or Nitride is used as etch hard mask for silicon fin etch, electrical results closer to that of an ideal NMOS transistor could would be achieved.
Primary Aberrations and Conjugate Change (1952)

Expressions are derived, in terms of the functions normally used in optical designing, for the variation with conjugates of the primary aberrations of any symmetrical system with isotropic object and image spaces. The possibilities of invariance of the aberrations, or their simultaneous correction for more than one magnification, are discussed
Colloid science resolves shale, formation-damage problems (1984)

Colloid chemistry techniques have advanced rapidly since development of new instrumentation. The knowledge gained is being applied to better design of drilling and completion fluids, better shale control, and custom-tailoring of fluids to specific formations. A resurgence of interest in ''shale stabilization'' followed the February 1981 introduction of a device to measure electrical charge on clay particles. It was used to optimize mud thinner treatments and prevent formation damage caused by electrostatic dispersion. The swellmeter and the capillary filtration timer were introduced in February 1982. These instruments proved valuable in redesigning muds to stop shale sloughing. So far, industry has barely begun to enjoy the benefits of using all three techniques together. But applied simultaneously, they have overcome some of the most severe drilling and production problems. This article reviews the progress of each new concept and shows how they can be used together. A flowchart for recommended testing and interpretation is provided. Operators can apply these techniques with only a few pounds of formation sample, a few hours time, and the cooperation of a drilling mud laboratory.
PEM Electrolysis H2A Production Case Study Documentation (2013)

This report documents the development of four DOE Hydrogen Analysis (H2A) case studies for polymer electrolyte membrane (PEM) electrolysis. The four cases characterize PEM electrolyzer technology for two hydrogen production plant sizes (Forecourt and Central) and for two technology development time horizons (Current and Future).
Unmanned Aircraft Systems Sense and Avoid Avionics Utilizing ADS-B Transceiver (2009)

To integrate Unmanned Aircraft Systems (UAS) into the U.S. National Airspace (NAS), the Federal Aviation Administration (FAA) requires “an equivalent level of safety, comparable to see -and -avoid requirements for manned aircraft.” A pr oposed FAA rulemaking would mandate Automatic Dependent Surveillance – Broadcast ( ADS -B) out equipage by 2020, forcing aircraft flying in the NAS to broadcast their state vector to Air Traffic Control (ATC) and aircraft equipped with ADS -B in capability . With the advent of lightweight, low power, and low -cost ADS -B units, the equipage and the use of ADS -B transceivers on small UAS are no longer limited by payload and power capabilities , and represent promising opportunities for the regulated operation of sm all UAS in the NAS. T he University of North Dakota (UND) has been actively developing enabling sense and avoid (SAA) technologies under a series of projects funded by the Department of Defense , and is now turning to ADS -B as the central component for mid -air collision avoidance . This paper presents the results of modeling collision avoidance algorithms using ADS -B derived information in a software -in -the -loop (SWIL) environment . Upon extensive testing, the system is designed to be integrated seamlessly in to a hardware -in -the -loop (HWIL) environment, and ultimately in a flight test environment aboard a small UAS.
AProgrammable IP Core for LDPC Decoder Based onASIP (2011)

This paper proposes a programmable soft IP core of a LDPC decoder based on ASIP (application-specific instruction set processor) which can support multi-mode specified in the IEEE802.11n standard. With the presented specific microinstructions based on ASIP architecture, the decoder can process all the codes for the IEEE802.11n standard in a programmable approach, effectively, and due to the proposed 6-stage pipeline, the decoder performance is improved greatly. To verify the design, the IP has been integrated into a embedded processor system based on Xilinx EDK on a Xilinx Virtex5 FPGA component. Finally, the Logic synthesis on 0.18μm CMOS technology from UMC reveals a maximum clock frequency of 203MHz and a total area of 3.94mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , and the corresponding power consumption is below 326.49mW.