gebhart/patrepeval huggingface dataset:
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system (2005)

To explore the role of DNA methylation in the brain, we examined the expression pattern of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the mouse central nervous system (CNS). By comparing the levels of Dnmt3a and Dnmt3b mRNAs and proteins in the CNS, we showed that Dnmt3b is detected within a narrow window during early neurogenesis, whereas Dnmt3a is present in both embryonic and postnatal CNS tissues. To determine the precise pattern of Dnmt3a and Dnmt3b gene expression, we carried out X-gal histochemistry in transgenic mice in which the lacZ marker gene is knocked into the endogenous Dnmt3a or Dnmt3b gene locus (Okano et al. [1999] Cell 99:247-257). In Dnmt3b-lacZ transgenic mice, X-gal-positive cells are dispersed across the ventricular zone of the CNS between embryonic days (E) 10.5 and 13.5 but become virtually undetectable in the CNS after E15.5. In Dnmt3a-lacZ mice, X-gal signal is initially observed primarily in neural precursor cells within the ventricular and subventricular zones between E10.5 and E17.5. However, from the newborn stage to adulthood, Dnmt3a X-gal signal was detected predominantly in postmitotic CNS neurons across all the regions examined, including olfactory bulb, cortex, hippocampus, striatum, and cerebellum. Furthermore, Dnmt3a signals in CNS neurons increase during the first 3 weeks of postnatal development and then decline to a relatively low level in adulthood, suggesting that Dnmt3a may be of critical importance for CNS maturation. Immunocytochemistry experiments confirmed that Dnmt3a protein is strongly expressed in neural precursor cells, postmitotic CNS neurons, and oligodendrocytes. In contrast, glial fibrillary acidic protein-positive astrocytes exhibit relatively weak or no Dnmt3a immunoreactivity in vitro and in vivo. Our data suggest that whereas Dnmt3b may be important for the early phase of neurogenesis, Dnmt3a likely plays a dual role in regulating neurogenesis prenatally and CNS maturation and function postnatally.
Insights into growth mechanism of silver halide tabular crystals: cubo-octahedral side faces (1993)

The nature and the geometry of the side-faces of the silver halide tabular crystal are considered from a theoretical point of view. The previously held view of the octahedral nature of the side-facesis modified to include other non-{111} planes, notably the {100} planes. Some of the predicted side-face geometries based on the cubo-octahedral planes are supported by the experimental evidence presented. The existence of perpetually growing high-aspect ratio tabular crystals with a single twin plane is predicted and experimentally verified
Obstacle localization and recognition for autonomous forklifts using omnidirectional stereovision (2015)

In this paper we propose an approach for obstacle localization and recognition using omnidirectional stereovision applied to autonomous fork-lifts in industrial environments. We use omnidirectional stereovision with two fisheye cameras for the 3D perception of the surrounding environment. Using the reconstructed 3D points, a Digital Elevation Map (DEM) is constructed consisting of a 2.5D grid of elevation cells. Each cell is then classified as ground or obstacle. Further, we use the classified DEM to generate obstacle hypotheses. To ensure a higher detection rate we also propose a fast sliding window based approach relying on the monocular fisheye intensity image. The detections from both approaches are merged and are subjected to a tracking mechanism. Finally each obstacle is classified using boosting over Visual Codebook type features. The classification is refined using the classification history available from tracking. The presented approaches are integrated into a 3D visual perception system for AGVs and are of real time performance.
Compact and fault-tolerant photonic crystal add drop filter (2003)

We propose an add-drop filter consisting of two adjacent waveguides carved into a two-dimensional photonic crystal that is etched through a standard guiding structure. This filter is based on distributed energy transfer via the frequency-selective intermediate conversion of the fundamental guided mode to a high-order low-group-velocity mode. This geometry circumvents the fabrication sensitivity on the single-hole scale of previous cavity-based designs. Combining distributed energy transfer and reduced group velocity preserves compactness. The design is analytically optimized with a coupled-mode approach.
18.1: <i>Invited Paper</i> : Flexibility Improvement of Foldable AMOLED with Touch Panel (2015)

The Flexible Universal Plane (FlexUP) technology was demonstrated with Polyimide (PI) substrate and a novel debonding method. Low Temperature Poly Silicon (LTPS) TFTs and OLEDs were developed along with the FlexUP technology, aiming to realize the foldability of AMOLED. With foldable AMOLED, the toughest challenge lies in the folding area with highly concentrated stress and fatigue which, when left unmanaged, will cause the product to fail. We have proposed several approaches to overcome these issues and have successfully demonstrated foldable AMOLED with touch panel modules at 5mm folding radius.
Changes of Antioxidant Contents during Grain Filling in Different Plant Types of Sesame (1993)

This study was conducted to obtain the fundamental information on antioxidant component as affected by process of grain filling in different plant types of sesame. Sesamin and sesamolin as antioxidant components, oil content and seed weight were investigated for two plant types with different by branching habit. The sesamin and sesamolin contents in grains followed a pattern of increase immediately after flowering in branch type and monocapsule habit than non-branch type and tricapsule habit. But they started to decrease around 45 days after flowering, which oil content and seed weight continued to increase until maturity. The sesamin content increased quickly up from 10th to 40th day after flowering and showed almost maximum at 43th day after flowering. The sesamolin content increased quickly up from 20th to 30th day after flowering and showed almost maximum at 45th day after flowering. The oil content increased quickly up from 20th to 30th day after flowering and showed almost maximum at 47th day after flowering. The seed weight increased quickly up from 20th to 40th day after flowering and showed almost maximum at 48th day. The sesamin content, sesamolin content, oil content and seed weight showed almost maximum at from 43th to 48th day after flowering. So that this period was considered to be of physiological maturity.
New Synthetic Approaches to Symmetrical Sulfur-Bridged Carbocycles (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Synthetic Approaches to Symmetrical Sulfur-Bridged CarbocyclesE. J. Corey and Eric BlockCite this: J. Org. Chem. 1966, 31, 6, 1663–1668Publication Date (Print):June 1, 1966Publication History Published online1 May 2002Published inissue 1 June 1966https://pubs.acs.org/doi/10.1021/jo01344a001https://doi.org/10.1021/jo01344a001research-articleACS PublicationsRequest reuse permissionsArticle Views471Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Das zerbrochene Weltengerüst (1989)

Kreative Arbeit, schöpferisches Erkennen beruhen nicht selten auf der Wahrnehmung von Analogien. Kreatives Arbeiten ist freilich nicht allein Privileg des Künstlers. Naturwissenschaftler (wenn sie innovativ sind) müssen auf die gleiche Weise ihre mathematisch-abstrakten Modelle veranschaulichen. Analogien sind Stimulantien auch des wissenschaftlichen Denkens, ganz besonders wenn es um die Verbildlichung nicht mehr vorstellbarer Dimensionen geht. So ist zum Beispiel — und damit sei das folgende Thema angerissen — „die Geometrie der Raumzeit zwar eine nichteuklidische Geometrie, besitzt aber zur euklidischen Geometrie viele Analogien“1. Wissenschaftliches Denken scheint darin zu bestehen, „dort Analogien zu sehen, wo jeder andere nur nackte Tatsachen sieht“. Nach Kant ist „die Analogie unerläßlich, um neue Erkenntnisse zu gewinnen“3. Aber es müssen auch Bedenken erlaubt sein. Roland Barthes etwa formuliert sie so: „Alle wissenschaftlichen Erklärungen, die auf die Analogie zurückgreifen — sie sind Legion -, haben Teil an der Täuschung, sie bilden das Imaginarium der Wissenschaft.“4
Molecular Insight into Fluorocarbon Adsorption in Pore Expanded Metal–Organic Framework Analogs (2020)

The rapid growth in the global energy demand for space cooling requires the development of more efficient environmental chillers for which adsorption-based cooling systems can be utilized. Here, in this contribution, we explore sorbents for chiller use via a pore-engineering concept to construct analogs of the 1-dimensional pore metal-organic framework MOF-74 by using elongated organic linkers and stereochemistry control. The prepared pore-engineered MOFs show remarkable equilibrium adsorption of the selected fluorocarbon refrigerant that is translated to a modeled adsorption-based refrigeration cycle. To probe molecular level interactions at the origin of these unique adsorption properties for this series of Ni-MOFs, we combined in situ synchrotron X-ray powder diffraction, neutron powder diffraction, X-ray absorption spectroscopy, calorimetry, Fourier transform infrared techniques, and molecular simulations. Our results reveal the coordination of fluorine (of CH<sub>2</sub>F in R134a) to the nickel(II) open metal centers at low pressures for each Ni-MOF analog and provide insight into the pore filling mechanism for the full range of the adsorption isotherms. The newly designed Ni-TPM demonstrates exceptional R134a adsorption uptake compared to its parent microporous Ni-MOF-74 due to larger engineered pore size/volume. The application of this adsorption performance toward established chiller conditions yields a working capacity increase for Ni-TPM of about 400% from that of Ni-MOF-74, which combined with kinetics directly correlates to both a higher coefficient of performance and a higher average cooling capacity generated in a modeled chiller.
Magnetic Properties of PLD-made Nd-Fe-B Film Magnets and their Applications to Milli-size Motors (2004)

We succeeded to deposite 200-300 μm thick Nd-Fe-B film magnets with (BH)max of approximately 55 kJ/m3 on Fe substrates by using PLD method. In addition, we confirmed that a milli-size motor, which was prepared from the obtained film, rotates at 15160 r/min under a no-load test.
Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model (2015)

Rational design of multi-targeted drug combinations is a promising strategy to tackle the drug resistance problem for many complex disorders. A drug combination is usually classified as synergistic or antagonistic, depending on the deviation of the observed combination response from the expected effect calculated based on a reference model of non-interaction. The existing reference models were proposed originally for low-throughput drug combination experiments, which make the model assumptions often incompatible with the complex drug interaction patterns across various dose pairs that are typically observed in large-scale dose-response matrix experiments. To address these limitations, we proposed a novel reference model, named zero interaction potency (ZIP), which captures the drug interaction relationships by comparing the change in the potency of the dose-response curves between individual drugs and their combinations. We utilized a delta score to quantify the deviation from the expectation of zero interaction, and proved that a delta score value of zero implies both probabilistic independence and dose additivity. Using data from a large-scale anticancer drug combination experiment, we demonstrated empirically how the ZIP scoring approach captures the experimentally confirmed drug synergy while keeping the false positive rate at a low level. Further, rather than relying on a single parameter to assess drug interaction, we proposed the use of an interaction landscape over the full dose-response matrix to identify and quantify synergistic and antagonistic dose regions. The interaction landscape offers an increased power to differentiate between various classes of drug combinations, and may therefore provide an improved means for understanding their mechanisms of action toward clinical translation.
MRI of Coronary Vessel Walls Using Radial k-Space Sampling and Steady-State Free Precession Imaging (2006)

Radial k-space sampling in MRI of coronary vessel walls resulted in fewer motion artifacts and improved SNR and CNR. The use of SSFP imaging, however, did not result in improved coronary vessel wall visualization.
Effects of Vitamin B<sub>12</sub> and Folate Deficiency on Brain Development in Children (2008)

Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two mechanisms linking folate and vitamin B12 deficiency to abnormal behavior and development in infants: disruptions to myelination and inflammatory processes. Future investigations should focus on the relationship between the timing of deficient and marginal vitamin B12 status and outcomes such as infant growth, cognition, social development, and depressive symptoms, along with prevention of folate and vitamin B12 deficiency.
Suppressing operator-induced oscillations in manual control systems with movable bases (2003)

There are many manual control tasks in which the operator's action is fed back to the input device, usually a joystick, through the operator's body dynamics excited by the base motion. This can lead to instability and reduced performance. This paper proposes a novel approach to the cancellation of such "biodynamic feedthrough". A prototype single-degree-of-freedom task in which the operator uses a force-reflecting joystick to position his/her base is considered here. A model-based approach is used to formulate /spl mu/-synthesis-based controllers that coordinate the motions of the joystick and the base. The solution is obtained by D-K iterations. The resultant controllers are robustly stable with respect to variations in the arm/joystick and biodynamic feedthrough parameters. They also provide a desired level of performance based upon position tracking between the joystick and the base and admittance shaping of the joystick. Experimental studies demonstrate the effectiveness of the proposed methods in the suppression of feedthrough induced oscillations. The approach developed in this paper, with some modifications, can be generalized to teleoperation from movable bases.
Syntheses of Sublimable Carbon Nitride Materials (1998)

Several potential synthesis routes to C3 N4 were reinvestigated. These include thermal decomposition of Hg(SCN)2 , thermal decomposition of CuSCN, and thermal deammonation of melamine. The C3 N4 material (1) obtained from Hg(SCN)2 contained Hg, S, an
Novel Designs for Application Specific MEMS Pressure Sensors (2010)

In the framework of developing innovative microfabricated pressure sensors, we present here three designs based on different readout principles, each one tailored for a specific application. A touch mode capacitive pressure sensor with high sensitivity (14 pF/bar), low temperature dependence and high capacitive output signal (more than 100 pF) is depicted. An optical pressure sensor intrinsically immune to electromagnetic interference, with large pressure range (0-350 bar) and a sensitivity of 1 pm/bar is presented. Finally, a resonating wireless pressure sensor power source free with a sensitivity of 650 KHz/mmHg is described. These sensors will be related with their applications in harsh environment, distributed systems and medical environment, respectively. For many aspects, commercially available sensors, which in vast majority are piezoresistive, are not suited for the applications proposed.
Direct Comparison between the Ulcer-Healing Effects of Two H<sup>+</sup>-K<sup>+</sup>-ATPase Inhibitors, One Mi-Selective Antimuscarinic and One H<sub>2</sub> Receptor Antagonist in the Rat (1990)

A direct comparison of the ulcer-healing effects of two H(+)-K(+)-ATPase inhibitors (pantoprazole and omeprazole), one M1 antimuscarinic (telenzepine) and one H2 receptor antagonist (cimetidine) was performed in the rat. Gastric and duodenal ulcers were induced by local application of acetic acid and thereafter treated over 10 days by the test drugs. Overall and on a molar basis, ulcer healing was comparably accelerated by pantoprazole, omeprazole and telenzepine and less so by cimetidine. The same rank order was found with respect to the inhibition of gastric acid secretion in the modified Shay rat.
<title>Projection of structured light in object planes of varying depths for absolute 3D profiling in a triangulation setup</title> (2001)

We are currently introducing a new scanning triangulation method for absolute 3D profiling of a macroscopic scene based on fringe projection technique. A scanning focal plane allows the phase to be determined for any desired depth range of the measurement volume. Furthermore, the limitations of the depth of focus occurring by projected light techniques will be overcome, allowing a large aperture and therefore better use of light. Two different systems based on this technique will be shown: System I uses both vertical and lateral translation of a Ronchi grating. System II uses an LCD element for generation of different fringes which has to be translated vertically, only. The basic principle of the new method is explained. First measurement results of both systems demonstrate the efficiency of the newly developed algorithms and the innovative measurement arrangements.
Surface Chemistry of Oxides (1976)

The chemistry of the surface of oxides depends to a !arge extent on the quantity and type of both physically
Nanostructured Copper Phthalocyanine-Sensitized Multiwall Carbon Nanotube Films (2007)

We report a detailed study of the interaction between surface-oxidized multiwall carbon nanotubes (o-MWCNTs) and the molecular semiconductor tetrasulfonate copper phthalocyanine (TS-CuPc). Concentrated dispersions of o-MWCNT in aqueous solutions of TS-CuPc are stable toward nanotube flocculation and exhibit spontaneous nanostructuring upon rapid drying. In addition to hydrogen-bonding interactions, the compatibility between the two components is shown to result from a ground-state charge-transfer interaction with partial charge transfer from o-MWCNT to TS-CuPc molecules orientated such that the plane of the macrocycle is parallel to the nanotube surface. The electronegativity of TS-CuPc as compared to unsubsubtituted copper phthalocyanine is shown to result from the electron-withdrawing character of the sulfonate substituents, which increase the molecular ionization potential and promote cofacial molecular aggregation upon drying. Upon spin casting to form uniform thin films, the experimental evidence is consistent with an o-MWCNT scaffold decorated with phthalocyanine molecules self-assembled into extended aggregates reminiscent of 1-D linearly stacked phthalocyanine polymers. Remarkably, this self-organization occurs in a fraction of a second during the spin-coating process. To demonstrate the potential utility of this hybrid material, it is successfully incorporated into a model organic photovoltaic cell at the interface between a poly(3-hexylthiophene):[6,6]-phenyl-C61 butyric acid methyl ester bulk heterojunction layer and an indium-tin oxide-coated glass electrode to increase the light-harvesting capability of the device and facilitate hole extraction. The resulting enhancement in power conversion efficiency is rationalized in terms of the electronic, optical, and morphological properties of the nanostructured thin film.
Guanine-plus-cytosine composition of five group B streptococcal serotypes (1977)

The percent guanine-plus-cytosine content of deoxyribonucleic acid of each of the five serotypes of group B streptococci was determined by thermal denaturation. The range of guanine-plus-cytosine content was 35.1 to 36.9%, with a mean value of 35.9%. These values suggest a genetic homogeneity to the serotypes of the group B streptococci.
An Adaptive Framework for Acoustic Monitoring of Potential Hazards (2009)

Robust recognition of general audio events constitutes a topic of intensive research in the signal processing community. This work presents an efficient methodology for acoustic surveillance of atypical situations which can find use under different acoustic backgrounds. The primary goal is the continuous acoustic monitoring of a scene for potentially hazardous events in order to help an authorized officer to take the appropriate actions towards preventing human loss and/or property damage. A probabilistic hierarchical scheme is designed based on Gaussian mixture models and state-of-the-art sound parameters selected through extensive experimentation. A feature of the proposed system is its model adaptation loop that provides adaptability to different sound environments. We report extensive experimental results including installation in a real environment and operational detection rates for three days of function on a 24 hour basis. Moreover, we adopt a reliable testing procedure that demonstrates high detection rates as regards average recognition, miss probability, and false alarm rates.