gebhart/patrepeval huggingface dataset:
Hydrogen abstraction from 2- and 3-methylthiophens investigated by spin trapping (1972)

The homolytic reactivity of 2- and 3-methylthiophens towards hydrogen abstraction from the side-chain by t-butoxyl radicals has been investigated by determining the relative amount either of the coupling products of 2- and 3-thenyl radicals or of the nitroxides obtained by trapping with ButNO. The conditions for the latter experiment have been explored and are discussed. Both methods showed that 2-methylthiophen is 2·2 time more reactive than the 3-isomer.
Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis (2014)

Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of acrylonitrile-based Michael acceptors, activated by aryl or heteroaryl electron-withdrawing groups. We demonstrate that thiol adducts of these acrylonitriles undergo β-elimination at rates that span more than 3 orders of magnitude. These rates correlate inversely with the computed proton affinity of the corresponding carbanions, enabling the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner. We apply these principles to the design of new reversible covalent kinase inhibitors with improved properties. A cocrystal structure of one such inhibitor reveals specific noncovalent interactions between the 1,2,4-triazole activating group and the kinase. Our experimental and computational study enables the design of new Michael acceptors, expanding the palette of reversible, cysteine-targeted electrophiles.
Spin valve and dual spin valve heads with synthetic antiferromagnets (1999)

Analytical and micromagnetic analysis have been performed for synthetic antiferromagnet (SAF) biased single and dual spin valve heads. It is found that for a un-pinned SAF under an external field, the antiparallel axis will flop to the direction orthogonal to the field direction. Introducing a thickness differential in the SAF can help to prevent the magnetization flop in addition to the exchange pinning. Design principles for SAF biased single and dual spin valve heads are presented. An SAF biased dual spin valve head with appropriate design can have significant advantages over the single spin valve besides higher GMR values.
Keeping the Fidelity in Stereo Catechesis: Opportunities and Dangers Inherent in Transmediation of the Gospel as Illustrated in <i>Sister Act I</i> and <i>II</i> (2006)

This paper examines the opportunities and dangers that can emerge when attempting to make the Gospel relevant to the “new culture” as articulated by French scholar Pierre Babin. It argues that inherent dangers exist when attempting to adapt the Gospel to the characteristics of members of the new culture. These inherent dangers–and the need to try to reach out despite them–are clearly illustrated in the Sister Act movies. Of particular note is the shift of focus from God toward music and personality as agents of change. The paper concludes by suggesting the term “interface” as a potentially useful addition to Babin’s lexicon in discussing transmediation and the Gospel.
GENETIC AND BIOCHEMICAL ASPECTS OF HUMAN BLOOD-GROUP A−, B−, H−, Lea − AND Leb− SPECIFICITY (1969)

Journal Article GENETIC AND BIOCHEMICAL ASPECTS OF HUMAN BLOOD-GROUP A−, B−, H−, Lea − AND Leb− SPECIFICITY: Get access W. T. J. MORGAN, C.B.E. D.Sc. F.R.S., W. T. J. MORGAN, C.B.E. D.Sc. F.R.S. Lister Institute of Preventive MedicineLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar WINIFRED M. WATKINS, Ph.D. D.Sc. WINIFRED M. WATKINS, Ph.D. D.Sc. Lister Institute of Preventive MedicineLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 25, Issue 1, January 1969, Pages 30–34, https://doi.org/10.1093/oxfordjournals.bmb.a070666 Published: 01 January 1969
Fast and slow muscles of the chick after nerve cross‐union (1967)

1. The multiply innervated anterior latissimus dorsi (ALD) and the focally innervated posterior latissimus dorsi (PLD) muscles of the chick were investigated 2-18 months after nerve cross-union.2. The fast PLD muscle re-innervated by the slow muscle nerve became supplied with ;en grappe' end-plates and responded to a single nerve volley with local potentials only. Control PLD muscles re-innervated by the original nerve, had ;en plaque' end-plates and responded to a single nerve volley by synchronous action potentials in the same way as normal muscles.3. In the slow ALD muscle re-innervated with the ;mixed' PLD nerve, the type of innervation and of electromyographic response remained practically unchanged, with the exception of transplanted ALD muscles supplied with PLD nerves where, in addition to local responses, propagated action potentials were registered electromyographically in response to single nerve volleys.4. ALD muscles of young chickens re-innervated both with an implanted purely fast muscle nerve and with the regenerated original nerve, had two types of innervation: ;en plaque' end-plates around the nerve implant, and multiple ;en grappe' end-plates in areas supplied with the ALD nerve. Accordingly, propagated action potentials were registered in response to single nerve volleys in regions near the implant, whereas local potentials were recorded in areas with original innervation.5. Contraction velocity was not substantially altered in PLD and ALD muscles after nerve cross-union.6. No changes were observed in the fine structure of muscle fibres in extrajunctional regions.
Multivascular networks and functional intravascular topologies within biocompatible hydrogels (2019)

Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.
Q-switched ruby laser for emission microspectroscopic elemental analysis (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQ-switched ruby laser for emission microspectroscopic elemental analysisNorman A. Peppers, Earl J. Scribner, Lloyd E. Alterton, Richard C. Honey, Edwin S. Beatrice, Ingeborg Harding. Barlow, Robert C. Rosan, and David. GlickCite this: Anal. Chem. 1968, 40, 8, 1178–1182Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/ac60264a016https://doi.org/10.1021/ac60264a016research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Introduction of the Cyano Group by Substitution of Oxygen Functions (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Three-dimensional integration of metal-oxide-semiconductor transistor with subterranean photonics in silicon (2006)

Monolithic integration of photonics and electronics has been achieved in silicon by three-dimensionally integrating metal-oxide-semiconductor field-effect transistors and waveguide-coupled microdisk resonators. Implantation of oxygen ions into a silicon-on-insulator substrate with a patterned thermal oxide mask followed by a high temperature anneal was utilized to realize the buried photonic structures. This results in the formation of vertically stacked silicon layers separated from each other by an intervening oxide layer. Transistors are fabricated on the surface silicon by conventional processing techniques. Optical and electronic functionalities are thus separated into two different layers of silicon, paving the way toward dense three-dimensional optoelectronic integration.
Study on Korean Ancient Diet by the Sacrificial Offerings of Japanese Temple (1991)

In the 7th century, Prince Shoudoku built the Horyu temple at Nara, when Buddhist culture in Japan had highly prospered after Buddhism were transmitted to Japan from Korea. At the same time, the three ancient country of Silla, Koguryo, and Baekjae had generally effected on Japanese culture and life as well as Buddhist events, religious services and sacrificial offerings in form. And even now there are kept above one thousand of tablewares which was used at the age and was made of wood and alloy manufactures from Han peninsular in Seisoin at Nara. Through these historical backgrounds, it could be presumed that the religious services and the sacrificial offerings for Prince Shodoku for above 1300 years help us to study and estimate the ancient dietary culture of Korean and Japanese. There are several points of similarities which are remained and maintained in Han Peninsular. 1. They used high filling method of the secrificial offerings and high receptacles in the religious service. 2. The cakes were mainly made of nonglutinous rice tharr glutinous rice 3. They decorated the pheonix instead of flowers and the other kinds of birds in Korea. 4. Kakiage of fried confectionary was founded in many kinds of them at present.
Rußland und die Europäische Union: eine widersprüchliche Zwischenbilanz (1999)

'Im folgenden Bericht, in dem ein russischer und ein deutscher Autor die Beziehungen zwischen Rußland und Europa analysieren, geht es weniger um die vieldiskutierte, doch oft reichlich abstrakte Frage: 'Ist Rußland Teil Europas?' Im Vordergrund stehen vielmehr die nach den Umbrüchen entstandenen Konzeptionen, wechselseitigen Perzeptionen und konkreten Ansätze für eine Partnerschaft. Die Beiträge wurden vor dem offenen Ausbruch der tiefgreifenden Wirtschafts- und Finanzkrise in Rußland vom Herbst 1998 verfaßt, deren Folgen für die Beziehungen Rußland-Europa allerdings berücksichtigt. Die Autoren sind der Ansicht, daß diese Beziehungen in ihren Grundzügen, Interessen und Perspektiven über die Krisenperiode hinaus ihre Gültigkeit behalten werden.' (Textauszug)
Phase Behavior of the Phytantriol/Water System (2003)

Phytantriol, 3,7,11,15-tetramethyl-1,2,3-hexadecanetriol, is frequiently used as a cosmetic ingredient; however, very little is known about its physical and chemical properti s. Here, we present the phase behavior of phytantriol in water, as determined by X-ray diffraction. At room temperature, the phase sequence upon increasing the water concentration is reversed micellar, lamellar, cubic phase Q(230), and cubic phase Q(224). At 44 degreesC, the cubic liquid crystals are transformed into a reversed hexagonal phase. The temperature-composition phase diagram of phytantriol/water mixtures is, thus, qualitatively similar to that of aqueous glycerol monooleate. The chemical stability of phytantriol makes it an interesting alternative to glycerol monooleate in exploiting various scientific and technical applications of, in particular, the cubic liquid crystalline phases.
Genetic variants of ribosomal DNA and mitochondrial DNA between swamp and river buffaloes (1994)

To clarify the genetic relationship between Swamp and River buffaloes, the restriction fragment length polymorphisms (RFLPs) of nuclear genomic ribosomal DNA (rDNA) and cytoplasmic mitochondrial DNA (mtDNA) were analysed. Blood or liver samples from 73 Swamp and three River buffaloes were collected in East and South-east Asian countries. DNA samples from cattle, goats and sheep were used for comparisons. The analysis of rDNA allowed water buffaloes, cattle, goats and sheep to be characterized by four distinct repeat-types. However, swamp and river buffaloes showed the same repeat-type. Divergence of water buffalo and cattle is considered to have occurred approximately four to six million years ago. The RFLPs for mtDNA divided water buffaloes into three haplotypes, swamp-1, swamp-2 and river types. Swamp-1 accounted for 91% of all swamp buffaloes while swamp-2 was observed only in water buffaloes from Thailand (9%). All river buffaloes were of the same haplotype. No differences were observed between swamp and river buffaloes at the rDNA level. In contrast, a few distinct differences between them were found at the mtDNA level. Therefore, mtDNA polymorphisms provide an adequate means for classifying water buffaloes into either swamp or river buffaloes.
Synthesis and ring-opening polymerization of 2-substituted 1,3-benzoxazine: the first observation of the polymerization of oxazine ring-substituted benzoxazines (2016)

2-Substituted 1,3-benzoxazines having a phenyl group as an oxazine ring substituent are synthesized with benzaldehyde through 2-hydroxy-<italic>N</italic>-phenylbenzylamine structures.
Supervised Random Walks: Predicting and Recommending Links in Social Networks (2010)

Predicting the occurrence of links is a fundamental problem in networks. In the link prediction problem we are given a snapshot of a network and would like to infer which interactions among existing members are likely to occur in the near future or which existing interactions are we missing. Although this problem has been extensively studied, the challenge of how to effectively combine the information from the network structure with rich node and edge attribute data remains largely open. We develop an algorithm based on Supervised Random Walks that naturally combines the information from the network structure with node and edge level attributes. We achieve this by using these attributes to guide a random walk on the graph. We formulate a supervised learning task where the goal is to learn a function that assigns strengths to edges in the network such that a random walker is more likely to visit the nodes to which new links will be created in the future. We develop an efficient training algorithm to directly learn the edge strength estimation function. Our experiments on the Facebook social graph and large collaboration networks show that our approach outperforms state-of-the-art unsupervised approaches as well as approaches that are based on feature extraction.
Mixed integer programming based nested partition algorithm for facility location optimization problems (2008)

Facility location optimization is very important for many retail industries, such as banking network, chain stores, and so on. Maximal covering location problem (MCLP) is one of the well-known models for these facility location optimization problems, which has earned extensive research interests. However, various practical requirements limit the application of the traditional formulation of MCLP, and the NP-hard characteristic makes effective approaches for large scale problems extremely difficult. This paper focuses on a facility location problem motivated by a practical project of bank branching. The traditional MCLP formulation is generalized as a mixed integer programming (MIP) with considerations of various costs and revenues, multi-type of facilities, and flexible coverage functions. A CPLEX-based hybrid nested partition algorithm is developed for large scale problems, and heuristic-based extensions are introduced to deal with extremely large problems. Our formulation and algorithm are embedded into an asset called IFAO-SIMO. Numerical results demonstrate the effectiveness and efficiency of our approach.
Aerosol-Processed Thermosensitive Nanocomposites for Controlled Drug Release (2014)

In this study, an ambient-spark-produced iron (Fe)-nanoparticle-laden nitrogen gas was mixed with an atomized solution of <i>N</i>-isopropylacrylamide (NIPAM)-polydimethylsiloxane (PDMS). The Fe nanoparticles reacted with NIPAM-PDMS in the atomized droplets to form encapsulated Fe nanoparticles, i.e., Fe@NIPAM-PDMS nanocomposites, whose size distribution was unimodal (showing only a NIPAM-PDMS-like distribution, with the Fe distribution eliminated). By varying processing temperatures, it was possible to obtain Fe@NIPAM-PDMS nanocomposites with different sizes and morphologies. This is further attributed to the quantitative incorporation of Fe nanoparticles into atomized NIPAM-PDMS-doxorubicin (DOX) droplets. The Fe@NIPAM-PDMS-DOX nanocomposites released different amounts of DOX under a magnetothermal effect, which produced different levels of cytotoxic effects on the targeted HeLa cells. The thermosensitivity makes these nanocomposites an ideal candidate for important applications such as controlled drug delivery.
Financial Simulation Using Distributed Computing Technology (1999)

This paper describes a JavaTM based and Internet-based simulation prototype for financial decision making. JavaTM was selected for software development because of the ease with which one could write code for complicated purposes and because of the security it provides while running across different platforms. The simulation game Robastrat was developed to show how distributed computing technology helps in building efficient and effective user-friendly simulation applications using JavaTM.
The effect of calcitonin on glucose metabolism. (1976)

The authors have studied the effect of calcitonin on glucose metabolism. Ten healthy volunteers were investigated. Calcitonin administered intramuscularly in one single dose inhibited the physiological decrease of blood glucose levels during the forenoon fast. Salmon calcitonin administered in an intravenous infusion in the dose of 0.15 U MRC/kg of body weight impaired the glucose tolerance test with the increase of blood glucose levels. The greatest difference was in the 120th minute after the administration of 100 gm of glucose. Calcitonin failed to produce any significant inhibition of immunoreactive insulin release following the glucose stimulus. However, further studies will be necessary to show whether this lack of the inhibitory beta cytotropic action of calcitonin was due to the low dose of calcitonin.
Communication in machine-to-machine environments (2012)

It has been estimated that by the end of 2020 there will be 50 billion connected devices in Machine-to-Machine (M2M) networks. Such projections should encourage us to deal with the corresponding problems in heterogeneous M2M systems. First of all, devices can communicate through different access technologies (e.g. wireline, 2G/3G, WiFi, Bluetooth) and their communication can be classified as direct or indirect, internal or external. In this paper we explain differences between those types of communication and propose a new identification scheme that allows M2M devices to establish communication in every possible way. Secondly, there is a problem of device hardware and software diversity. To over-come this problem, we propose the usage of the Open Service Gateway Initiative (OSGi) framework.
Fluoxetine in depressed patients: a comparison with imipramine. (1984)

The clinical efficacy and safety of fluoxetine and imipramine were compared in a double-blind, 5-week, parallel study in 40 depressed outpatients. Mean scores for most depression scales improved more in patients taking fluoxetine than in those receiving imipramine (p less than .05). Nine of 16 (56%) fluoxetine patients who completed the study and 1 of 19 (5%) imipramine patients were not at all depressed at the end of the study (p less than .001). Seven fluoxetine patients and 14 imipramine patients reported one or more adverse effects during treatment; no fluoxetine patient terminated the study early for drug-related reasons. It was concluded that fluoxetine provides effective antidepressant activity with fewer and less troublesome side effects than imipramine.
Study of the functional anatomy of bovine cervical mucosa with special reference to mucus secretion and sperm transport (1989)

The bovine cervical mucosa was investigated with respect to structure, mucus secretory pattern, and sperm transport. Structural investigation included stereomicroscopic examination of surface-stained tissue blocks and graphic reconstruction of serial sections by using both computer-generated and Plexiglas models. Histochemistry of the mucosa was evaluated in follicular- and luteal-phase animals. Alcian blue, periodic acid Schiff, and high-iron diamine were utilized to distinguish sialomucins, sulfomucins, and neutral mucins. Location and orientation of cervical sperm in follicular phase animals were evaluated 12 h postmating by using light and electron microscopy. Cervical mucosa was characterized by longitudinal primary folds, most of which maintained continuity throughout the cervix. Superimposed on these were secondary folds which varied in length and depth. Abundant, shallow, uniformly spaced, and parallel longitudinal "grooves" covered all surfaces. Grooves had greater continuity in regions distal, as opposed to proximal, to the cervical canal. Blind-ending glands or crypts were not apparent. Follicular-stage cervices exhibited a pronounced sialomucin production in basal areas within grooves while neutral and sulfomucins were predominant in apical areas. In luteal-phase animals, basal sialomucin production was markedly decreased while sulfated and neutral mucins remained abundant. Numerous cranially oriented spermatozoa were observed within the shallow grooves of cervical folds (sialomucin-rich areas) in mated animals and were unidirectionally opposed to ciliary beat. It appeared that privileged paths for transport of viable spermatozoa may originate in the fornix vagina, extend through longitudinal primary folds at the external os, and progress to the uterus within continuous sialomucin-rich channels which are associated with basal areas of the shallow grooves, distal to the cervical canal.