gebhart/patrepeval huggingface dataset:
The association of microtubules with an acid phosphatase-containing tubular compartment in macrophages. (1992)

Received for publication October 8, 1991 and in revised form January 10, 1992 Resident peritoneal murine macrophages typically have acid phosphatase (AcPase) activity in lysosomes which are spherical in shape and have a perinuclear distribution. Upon stimulation with certain phorbol esters there is a rapid and dramatic modification of the AcPase-containing compartment into tubular structures which are often interconnected. The formation and maintenance of these tubular structures are dependent upon the presence of an intact microtubule system. Treatment of cells with the microtubule-depolymerizing agent nocodazole blocks the formation of the tubular structures and causes these tubular compartments to collapse toward the nucleus when nocodazole is administered after they are formed. We have employed whole mount electron microscopy and enzyme cytochemistry to document the association of the phorbol ester-induced AcPase-containing compartment and cytoplasmic microtubules. This methodological approach has the advantage of increased resolution when compared to optical microscopy and of an improved vantage point for analysis when compared to conventional thin section electron microscopy.
The Influence of Taste on Swallowing Apnea, Oral Preparation Time, and Duration and Amplitude of Submental Muscle Contraction (2006)

Prior research has documented a modulating effect of taste on swallowing. We hypothesized that presentation of tastant stimuli would be a significant variable in swallowing-respiratory coordination, duration of oral bolus preparation, and submental muscle contraction. Twenty-three healthy females were presented with 1-cm(3) gelatin samples flavored with 4 tastants of increasing intensities. Visual analogue scale ratings of perceived intensity of each were used to identify relative equivalent concentrations across the 4 tastants. Data were then collected during ingestion of 5 trials of the 4 equivalent tastants using measurements of nasal airflow and submental surface electromyography (sEMG) to record biomechanical measures. Chi-square analysis failed to identify a statistically significant influence of taste on the phase location of swallowing apnea. Repeated measures analysis of variance demonstrated significant taste effects for oral preparation time, submental sEMG amplitude, and duration (P < 0.02). Sweet tastants were prepared for a shorter time when compared with bitter tastants. Swallow duration for sour, salty, and bitter tastants were longer than sweet and neutral tastants. Sour tastants resulted in the greatest amplitude of submental muscle contraction during swallowing. This study supports existing research that found that sour substances were swallowed with more effort when compared with other tastes.
ViDeNN: Deep Blind Video Denoising (2019)

We propose ViDeNN: a CNN for Video Denoising without prior knowledge on the noise distribution (blind denoising). The CNN architecture uses a combination of spatial and temporal filtering, learning to spatially denoise the frames first and at the same time how to combine their temporal information, handling objects motion, brightness changes, low-light conditions and temporal inconsistencies. We demonstrate the importance of the data used for CNNs training, creating for this purpose a specific dataset for low-light conditions. We test ViDeNN on common benchmarks and on self-collected data, achieving good results comparable with the state-of-the-art.
Formal Enantiospecific Synthesis of (+)-FR900482 (2002)

The enantiospecific synthesis of FK973, and thus a formal enantiospecific synthesis of the antitumor antibiotic (+)-FR900482, is reported. Addition of aniline 8 to chiral epoxide 9, prepared from l-vinylglycine, afforded amino alcohol 12. After protection of the aliphatic nitrogen with the 9-phenylfluoren-9-yl group, to preserve the acidic stereocenter from racemization, formation of the aziridine 14 and intramolecular condensation under basic conditions gave azocinone 15. Hydroxymethylation at the benzylic position was achieved by a process involving methylenation, epoxidation, and hydrogenolysis; the absolute stereochemistry of the resulting alcohol 23 was determined by X-ray crystallographic analysis. The hydroxyl group of 23 was carbamoylated, and the aromatic amine was deprotected electrochemically and then oxidized to give an unstable hydroxylamine that was immediately protected as acetate 26. Oxidation of 26 with DMP, followed by hydrazinolysis of the acetyl group led to spontaneous closure of the resulting N-hydroxyamino ketone to hemiketal 28, which can be considered as a fully protected precursor of FR900482 and derivatives. Acid treatment to remove the protecting groups and acetylation afforded the triacetate FK973.
ExoBuilding (2010)

ExoBuilding explores the novel design space that emerges when an individual‟s physiological data and the fabric of building architecture are linked. In its current form ExoBuilding is a tent-like structure that externalises a person‟s physiological data in an immersive and visceral way. This is achieved by mapping abdominal breathing to its shape and size, displaying heart beat through sound and light effects and mapping electro dermal activity to a projection on the tent fabric. The research is positioned in relation to previous work and the iterative development of ExoBuilding from to-scale to full-size prototype is described. The design process, feedback gathered alongside and observations allow the discussion of wider issues: the different scales possible, the temporal nature of the data, ownership and ambiguity of that data, ranges of control and the aggregation of data in a building context. This leads to the presentation of directions for future research at this exciting boundary between Architecture, HCI and medical science.
Assembly and multiple gene expression of thermophilic enzymes in <i>Escherichia coli</i> for in vitro metabolic engineering (2014)

In vitro reconstitution of an artificial metabolic pathway is an emerging approach for the biocatalytic production of industrial chemicals. However, several enzymes have to be separately prepared (and purified) for the construction of an in vitro metabolic pathway, thereby limiting the practical applicability of this approach. In this study, genes encoding the nine thermophilic enzymes involved in a non-ATP-forming chimeric glycolytic pathway were assembled in an artificial operon and co-expressed in a single recombinant Escherichia coli strain. Gene expression levels of the thermophilic enzymes were controlled by their sequential order in the artificial operon. The specific activities of the recombinant enzymes in the cell-free extract of the multiple-gene-expression E. coli were 5.0-1,370 times higher than those in an enzyme cocktail prepared from a mixture of single-gene-expression strains, in each of which a single one of the nine thermophilic enzymes was overproduced. Heat treatment of a crude extract of the multiple-gene-expression cells led to the denaturation of indigenous proteins and one-step preparation of an in vitro synthetic pathway comprising only a limited number of thermotolerant enzymes. Coupling this in vitro pathway with other thermophilic enzymes including the H2 O-forming NADH oxidase or the malate/lactate dehydrogenase facilitated one-pot conversion of glucose to pyruvate or lactate, respectively.
Using IC cards to remotely login passwords without verification tables (2004)

A new remote password authentication scheme based on IC cards is proposed in this paper. By using the scheme, a remote password can be authenticated without either a password file or a verification table. A user first applies for an account in the financial organization and then uses the given IC card to login. In the login phase, a user inputs the identity and password, transmits the generated values to the center. In the authentication phase, the system uses the secret key and remotely submitted message to verify whether the request is legal or not. A one-time-used random number and a timestamp are supplied to protect the potential attacks, which may replay a previously intercepted login request. Further, by using the characteristics of IC cards, the proposed scheme is very suitable for authenticating passwords remotely.
Risk of stroke after transcatheter aortic valve implantation (TAVI): a meta-analysis of 10,037 published patients (2012)

TAVI was associated with average 30-day stroke/TIA rate of 3.3 ± 1.8% (range 0-6%). Most of these strokes were major strokes and were associated with increased mortality within in the first 30 days.
Measurement of changes in high-energy phosphates in the cardiac cycle using gated 31P nuclear magnetic renonance. (1980)

Levels of the high-energy phosphate-containing compounds, ATP and creatine phosphate, and of inorganic phosphate (Pi) were measured as a function of position in the cardiac cycle. Measurements were made on isolated, perfused, working rat hearts through the use of gated 31P nuclear magnetic resonance spectroscopy. Levels of ATP and creatine phosphate were found to vary during the cardiac cycle and were maximal at minimal aortic pressure and minimal at maximal aortic pressure. Pi varied inversely with the high-energy phosphates.
Perfluorinated-ionomer-membrane-based microcomposites: silicon oxide filled membranes (1989)

The objective of this work was to affect the in situ growth of silicon oxide microclusters or interpenetrating networks in Nation membranes via the sol-gel reaction for tetraethoxysilane (TEOS). The underlying hypotheses are: 1) The resultant morphology of the inorganic phase is ordered by the polymer's phase-separated morphology. 2) TEOS/ alcohol/H2O solutions will preferentially incorporate within pre-existing polar clusters. 3) TEOS hydrolysis in clusters is catalyzed by the fixed SO3H groups. Reproducible procedures for the in situ growth of "silica" in hydrated membranes contacting TEOS/alcohol solutions were established. Solids uptake vs. immersion time curves are a function of alcohol solvent type. Tensile properties vs. solids uptake indicate an initial strengthening, followed by a ductile-brittle transition suggesting a silicon oxide phase percolation threshold. FT-IR and 29Si solid state NMR analyses of microstructural evolution portray an inorganic network that is not as highly crosslinked as that of sol-gel-derived free silica and in fact becomes less coordinated and connected with increasing solids uptake.
Reality portals (1999)

Through interactive augmented virtuality we provide the ability to interactively explore a remote space inside a virtual environment. This paper presents a tool and technique that can be used to create such virtual worlds that are augmented by video textures taken of real world objects. The system constructs and updates, in near real-time, a representation of the user-defined salient and relevant features of the real world. This technique has the advantage of constructing a virtual world that contains the relevant video-data of the real world, while maintaining the flexibility of a virtual world. The virtual-real world representation is not dependent on physical location and can be manipulated in a way not subject to the temporal, spatial, and physical constraints found in the real world. Another advantage is that spatializing the video-data may afford more intuitive examination.
Education policy in the Republic of Korea - building block or stumbling block? (2001)

While noting the benefits of strong public sector involvement in Korea's educational system, e.g., equal access, common standards, this paper draws attention to one major drawback, namely, the poor quality of secondary, and tertiary education. As a result of this, Korean households spend a significant proportion of their income on private tuition, supplementary educational materials, and overseas education. The paper notes that it may be time for Korea to shift to a more flexible educational system, allowing greater scope for students, and teachers to select each other, more incentives for improving teacher quality, and, a simplified, and decentralized educational administration set-up.
Downregulated Expression of SHP-1 in Burkitt Lymphomas and Germinal Center B Lymphocytes (1997)

We wish to identify developmental changes in germinal center B cells that may contribute to their rapid growth. SHP-1 is an SH2 domain-containing phosphotyrosine phosphatase that negatively regulates activation of B cells and other cells of hematopoietic lineages. We have found that in all 13 EBV-negative and 11 EBV-positive Burkitt lymphomas with a nonlymphoblastoid phenotype, the mean concentration of SHP-1 was reduced to 5% of that of normal B and T cells. The possibility that this diminished expression of SHP-1 was related to the germinal center phenotype of Burkitt lymphomas was supported by the low to absent immunofluorescent staining for SHP-1 in germinal centers, and by the inverse relationship between the concentration of SHP-1 and the expression of the germinal center marker CD38 on purified tonsillar B cells. In CD38-high B cells, SHP-1 concentration was 20% of that of mantle zone B cells from the same donor. This reduction in SHP-1 is comparable to that of cells from motheaten viable mev/mev mice in which there is dysregulated, spontaneous signaling by cytokine and antigen receptors. Therefore, germinal center B cells may have a developmentally regulated, low threshold for cellular activation.
MicroRNA profiling of tomato leaf curl new delhi virus (tolcndv) infected tomato leaves indicates that deregulation of mir159/319 and mir172 might be linked with leaf curl disease (2010)

The expression of several host miRNAs is affected in response to viral infection. The levels of the corresponding pre-miRs and the predicted targets were also deregulated. This change in miRNA expression levels was specific to leaf tissues and observed to be associated with disease progression. Thus, certain host miRs are likely indicator of viral infection and could be potentially employed to develop viral resistance strategies.
Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein (2009)

Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of alpha-synuclein (alpha-syn) and contributes to the pathogenesis of PD remains unknown. Using site-directed mutagenesis combined with detailed biophysical and mass spectrometry analyses, we sought to identify the exact residues involved in tTG-catalyzed cross-linking of wild-type alpha-syn and alpha-syn mutants associated with PD. To better understand the structural consequences of each cross-linking reaction, we determined the effect of tTG-catalyzed cross-linking on the oligomerization, fibrillization, and membrane binding of alpha-syn in vitro. Our findings show that tTG-catalyzed cross-linking of monomeric alpha-syn involves multiple cross-links (specifically 2-3). We subjected tTG-catalyzed cross-linked monomeric alpha-syn composed of either wild-type or Gln --> Asn mutants to sequential proteolysis by multiple enzymes and peptide mapping by mass spectrometry. Using this approach, we identified the glutamine and lysine residues involved in tTG-catalyzed intramolecular cross-linking of alpha-syn. These studies demonstrate for the first time that Gln(79) and Gln(109) serve as the primary tTG reactive sites. Mutating both residues to asparagine abolishes tTG-catalyzed cross-linking of alpha-syn and tTG-induced inhibition of alpha-syn fibrillization in vitro. To further elucidate the sequence and structural basis underlying these effects, we identified the lysine residues that form isopeptide bonds with Gln(79) and Gln(109). This study provides mechanistic insight into the sequence and structural basis of the inhibitory effects of tTG on alpha-syn fibrillogenesis in vivo, and it sheds light on the potential role of tTG cross-linking on modulating the physiological and pathogenic properties of alpha-syn.
Advanced Energy Management of a Novel Independent Metering Meter-Out Control System: A Case Study of an Excavator (2018)

An independent metering (IM) system is a promising alternative to the conventional loadsensing (LS) system. However, the common meter-in control method has impeded further improvement in energy efficiency and investment costs. This paper presents a novel energy management algorithm that combines meter-out (MO) valve control with pressure/flow hybrid pump control. First, the energy-saving performance and dynamic characteristics are analyzed. Then, by designing a coordinate control between the pump and valves, the system has mode switching, MO flow/pressure control, flow distribution, anti-flow saturation, and electronic overload protection capabilities. Compared with the general IM control coupling with a LS system, the proposed method has fewer throttling losses, better dynamic control, and higher application adaptability. This study is applied to a hydraulic-mechanical coupling model of a 2-ton mini excavator to compare the proposed control system with an LS system. Typical continuous actions, such as digging and dumping, are conducted to analyze energy efficiency and controllability, and some special operating conditions, such as flow saturation and pressure/power overload, are also studied.
Expression of Epstein‐Barr virus‐encoded proteins in nasopharyngeal carcinoma (1988)

Expression of the Epstein-Barr virus (EBV) encoded nuclear antigens (EBNA 1 to 6) and membrane-associated protein (LMP) was investigated by immunoblotting in 83 nasopharyngeal carcinoma (NPC) biopsies and 25 other tumor and normal tissue specimens from the head and neck region. Fifty-eight of the 83 NPC biopsies were large enough to yield parallel data on virus DNA and viral expression. All 16 cases of clinically diagnosed and histologically confirmed NPCs from North Africa contained EBV DNA and expressed EBNA-1. Of 31 clinically diagnosed NPCs from China, 29 contained EBV DNA and 25 of these expressed EBNA-1. One control tissue biopsy from the oropharynx of NPC patients contained EBV DNA, but none expressed EBNA-1. The latent membrane protein (LMP) was detected in 22/31 of the Chinese and in 10/16 of the North African NPC biopsies. None of the NPC biopsies or control tissues expressed detectable amounts of EBNA 2 or any of the other 4 nuclear antigens which are invariably expressed in EBV-transformed B cells. A smaller number of tumors from Malaysia and East Africa exhibited a similar pattern of expression. EBV was rescued from a nude-mouse-passaged North African NPC tumor by co-cultivation of the tumor cells with umbilical cord blood lymphocytes. The tumor expressed EBNA 1 and LMP, but not EBNA 2 or the other 4 EBNAs. The resulting LCLs expressed all 6 nuclear antigens, EBNA 1 to 6 and LMP. Our data suggest that expression of the EBV genome is regulated in a tissue-specific fashion.
Robust compressive multi‐input–multi‐output imaging (2013)

Canonical multi‐input–multi‐output (MIMO) imaging methods suffer from limited resolution, poor robustness against noise and high computational complexity, especially when the array aperture is limited (affecting angular resolution) and the number of snapshots is limited (affecting Doppler resolution). In this study, the authors discuss a new range‐angle‐Doppler monostatic MIMO imaging method through adaptive estimation of the generalised Cauchy prior distribution (GCD). The superiority of GCD‐based model over existing ℓ p ‐norm‐based model (which actually assumes the prior as general Gaussian distribution) is theoretically verified through the issue of signal compressibility. The authors adapt a reweighted ℓ 2 ‐norm iterative algorithm to solve the model. In our model the authors do not pre‐define the scaling factor of the prior distribution and, during the iteration, the authors use a novel ‘quantile‐of‐OS’ method to adaptively estimate the scaling parameter of the prior distribution, enhancing the robustness of the method. Simulation results verify the image quality and speed advantages of the proposed method.
Sehda s 2 MT: incorporation of syntax into statistical translation system. (2005)

This paper describes Sehda’s S 2 MT (Syntactic Statistical Machine Translation) system submitted to the Korean-English track in the evaluation campaign of the IWSLT-05 workshop. The S 2 MT is a phrase-based statistical system trained on linguistically processed parallel data. 1.
The dose uptake ratio as an index of glucose metabolism: useful parameter or oversimplification? (1994)

These data indicate that DUR can vary widely with the time of measurement and that DUR should be interpreted with caution in any individual patient.
Tracheal Replacements: Part 1 (2007)

In this review, we summarize the history of tracheal reconstruction and replacement as well as progress in current tracheal substitutes. In Part 1, we cover the historical highlights of grafts, flaps, tube construction, and tissue transplants and address the progress made in tracheal stenting as a means of temporary tracheal support. This is followed in Part 2 by an analysis of solid and porous tracheal prostheses in experimental and clinical trials. We conclude Part 2 with a summary of recent efforts toward generating a bioengineered trachea. Finally, we provide an algorithm on the spectrum of options available for tracheal replacement.
EIGER detector: application in macromolecular crystallography (2016)

The development of single-photon-counting detectors, such as the PILATUS, has been a major recent breakthrough in macromolecular crystallography, enabling noise-free detection and novel data-acquisition modes. The new EIGER detector features a pixel size of 75 × 75 µm, frame rates of up to 3000 Hz and a dead time as low as 3.8 µs. An EIGER 1M and EIGER 16M were tested on Swiss Light Source beamlines X10SA and X06SA for their application in macromolecular crystallography. The combination of fast frame rates and a very short dead time allows high-quality data acquisition in a shorter time. The ultrafine ϕ-slicing data-collection method is introduced and validated and its application in finding the optimal rotation angle, a suitable rotation speed and a sufficient X-ray dose are presented. An improvement of the data quality up to slicing at one tenth of the mosaicity has been observed, which is much finer than expected based on previous findings. The influence of key data-collection parameters on data quality is discussed.
After You’ve Seen the Fair (1939)

Essay| June 01 1939 After You’ve Seen the Fair Helen F. Brown Helen F. Brown Search for other works by this author on: This Site PubMed Google Scholar Current History (1939) 50 (4): 55–64. https://doi.org/10.1525/curh.1939.50.4.55 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Helen F. Brown; After You’ve Seen the Fair. Current History 1 June 1939; 50 (4): 55–64. doi: https://doi.org/10.1525/curh.1939.50.4.55 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1939 by The Regents of the University of California1915 Article PDF first page preview Close Modal You do not currently have access to this content.
Bone Marrow Derived Mesenchymal Stem Cells as Antiglioma Cellular Vector (2007)

Traditional vector and neural stem cell have defect in glioma gene therapy. Recent research indicates that bone marrow derived mesenchymal stem cells as a neotype antiglioma cellular vector possessed more merit in excellent migratory ability,tropism,low immunogenicity and immunological regulation,et al.