gebhart/patrepeval huggingface dataset:
The Structure of Novobiocin<sup>1,2</sup> (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Novobiocin1,2J. W. Hinman, E. Louis Caron, and Herman HoeksemaCite this: J. Am. Chem. Soc. 1957, 79, 14, 3789–3800Publication Date (Print):July 1, 1957Publication History Published online1 May 2002Published inissue 1 July 1957https://doi.org/10.1021/ja01571a047RIGHTS & PERMISSIONSArticle Views298Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Cytokeratins 8 and 19 in the Mouse Placental Development (2000)

To investigate the expression and biological roles of cytokeratin 19 (K19) in development and in adult tissues, we inactivated the mouse K19 gene (Krt1-19) by inserting a bacterial beta-galactosidase gene (lacZ) by homologous recombination in embryonic stem cells, and established germ line mutant mice. Both heterozygous and homozygous mutant mice were viable, fertile, and appeared normal. By 7.5-8.0 days post coitum (dpc), heterozygous mutant embryos expressed lacZ in the notochordal plate and hindgut diverticulum, reflecting the fact that the notochord and the gut endoderm are derived from the axial mesoderm-originated cells. In the adult mutant, lacZ was expressed mainly in epithelial tissues. To investigate the possible functional cooperation and synergy between K19 and K8, we then constructed compound homozygous mutants, whose embryos died approximately 10 dpc. The lethality resulted from defects in the placenta where both K19 and K8 are normally expressed. As early as 9. 5 dpc, the compound mutant placenta had an excessive number of giant trophoblasts, but lacked proper labyrinthine trophoblast or spongiotrophoblast development, which apparently caused flooding of the maternal blood into the embryonic placenta. These results indicate that K19 and K8 cooperate in ensuring the normal development of placental tissues.
Miniaturized Triple-Band Antenna With a Defected Ground Plane for WLAN/WiMAX Applications (2011)

A miniaturized multifrequency antenna is proposed. The proposed antenna can generate three separate impedance bandwidths to cover all the 2.4/5.2/5.8-GHz WLAN operating bands and the 2.5/3.5/5.5-GHz WiMAX bands. The proposed microstrip-fed antenna mainly consists of a circular ring, a Y-shape-like strip, and a defected ground plane. By adding a Y-shape-like strip in the circular ring, the antenna excites two resonant modes and is with miniaturization structure. Because of the introduction of the cambered ground plane with an isosceles triangle-defect, the third wide band with better impedance matching is obtained. A prototype is experimentally tested, and the measured results show good radiation patterns and enough gains across the operation bands.
Down-regulation of Notch1 or Notch3 can decrease the migration and invasion of HepG2 and MHCC97H cells in vitro. (2015)

<p>(a–c) Migrated HCC cells analyzed by transwell assays compared with siRNA controls. (d–f) Invaded HCC cells analyzed by transwell assays compared with siRNA controls. The data are presented as the mean ± SD, *P<0.05 compared with control siRNA-transfected HepG2 cells; #P<0.05 compared with control siRNA-transfected MHCC97H cells. NT: No transfection; Cs: control siRNA transfection; N1s: Notch1 siRNA transfection; N3s: Notch3 siRNA transfection.</p>
The σ<sup>E</sup>‐mediated response to extracytoplasmic stress in <i>Escherichia coli </i>is transduced by RseA and RseB, two negative regulators of σ<sup>E</sup> (1997)

The extracytoplasmic stress response in Escherichia coli is controlled by the alternative sigma factor, sigma(E). sigma(E) activity is uniquely induced by the accumulation of outer membrane protein precursors in the periplasmic space, and leads to the increased production of several proteins, including the periplasmic protease DegP, that are thought to be required for maintaining cellular integrity under stress conditions. Genetic and biochemical experiments show that sigma(E) activity is under the control of three genes, rseABC (for regulator of sigma E), encoded immediately downstream of the sigma factor. Deletion of rseA leads to a 25-fold induction of sigma(E) activity. RseA is predicted to be an inner membrane protein, and the purified cytoplasmic domain binds to and inhibits sigma(E)-directed transcription in vitro, indicating that RseA acts as an anti-sigma factor. Deletion of rseB leads to a slight induction of sigma(E), indicating that RseB is also a negative regulator of sigma(E). RseB is a periplasmic protein and was found to co-purify with the periplasmic domain of RseA, indicating that RseB probably exerts negative activity on sigma(E) through RseA. Deletion of rseC, in contrast, has no effect on sigma(E) activity under steady-state conditions. Under induction conditions, strains lacking RseB and/or C show wild-type induction of sigma(E) activity, indicating either the presence of multiple pathways regulating sigma(E) activity, or the ability of RseA alone to both sense and transmit information to sigma(E).
Virus-Host Interactions: Induction of Chlorotic and Necrotic Responses in Plants by Tobamoviruses (1991)

Beneficial microbes in the microbiome of plant roots improve plant health. Induced systemic resistance (ISR) emerged as an important mechanism by which selected plant growth–promoting bacteria and fungi in the rhizosphere prime the whole plant body for ...Read More
The Course of Psychopathologic Features in Mild to Moderate Alzheimer Disease (1997)

Behavioral disturbance, particularly agitation, is common and persistent in patients with Alzheimer disease. Psychotic symptoms are less common and show moderate persistence over time. Depressed mood with vegetative signs is uncommon and rarely persists. These findings suggest leads about the optimal treatment duration for specific subtypes of psychopathologic features.
Effect of deoxyribonuclease I treatment for dementia in end-stage Alzheimer’s disease: a case report (2016)

Our patient began to demonstrate rapid, considerable improvement in cognitive function 2 days following initiation of deoxyribonuclease I treatment. After 2 months of continued treatment, Mini-Mental State Examination and Functional Assessment Staging Test scores were 18 and 4, respectively.
Dirac materials (2014)

A wide range of materials, like d-wave superconductors, graphene, and topological insulators, share a fundamental similarity: their low-energy fermionic excitations behave as massless Dirac particles rather than fermions obeying the usual Schrodinger Hamiltonian. This emergent behavior of Dirac fermions in condensed matter systems defines the unifying framework for a class of materials we call "Dirac materials''. In order to establish this class of materials, we illustrate how Dirac fermions emerge in multiple entirely different condensed matter systems and we discuss how Dirac fermions have been identified experimentally using electron spectroscopy techniques (angle-resolved photoemission spectroscopy and scanning tunneling spectroscopy). As a consequence of their common low-energy excitations, this diverse set of materials shares a significant number of universal properties in the low-energy (infrared) limit. We review these common properties including nodal points in the excitation spectrum, density of states, specific heat, transport, thermodynamic properties, impurity resonances, and magnetic field responses, as well as discuss many-body interaction effects. We further review how the emergence of Dirac excitations is controlled by specific symmetries of the material, such as time-reversal, gauge, and spin-orbit symmetries, and how by breaking these symmetries a finite Dirac mass is generated. We give examples of how the interaction of Dirac fermions with their distinct real material background leads to rich novel physics with common fingerprints such as the suppression of back scattering and impurity-induced resonant states.
Discrete-Time Sliding Mode Control: The Linear Case (1997)

This paper discusses the application of a class of discrete-time sliding mode controllers (DSMC) which was previously shown to be robustly stable. Further insight into design and performance of DSMC is obtained considering the case of linear plants. A simple numerical example is used to illustrate the properties of this technique.
The prospects for domesticating milk protein genes (1992)

It is possible to convert milk glands of transgenic animals into bioreactors producing heterologous proteins such as scarce human pharmaceuticals. To predictably and successfully engineer the milk gland, we will need a thorough understanding of its physiology. Expression studies in transgenic animals have located mammary specific and hormone inducible transcription elements in the promoter/upstream regions of milk protein genes, and transfection studies in cell lines or primary cells have identified constitutive and hormone inducible elements. Most importantly, it appears that in addition to individual promoter based transcription elements structural features of milk protein chromosomal loci may contribute to the tight developmental and hormonal regulation. I will discuss milk protein gene regulation with emphasis on regulatory differences between genes and species, and the possibility that transcription elements function only properly within genetically defined chromatin domains. Novel strategies to build mammary expression vectors and to test their functionality without pursuing the standard transgenic route will be presented. Finally, I will discuss homologous recombination with the goal to target milk protein genes. Only through the domestication of milk protein genes will we be able to use their full potential in the mammary bioreactor.
Near-bandgap ultrafast optical responses of furnace annealed arsenic-ion-implanted GaAs (2002)

Recently, a new class of photoconductors with excess-arsenic-related deep level defects, arsenic-ion-implanted (or GaAs:As/sup +/), has been the subject of intense study. Ultrafast carrier lifetimes, photoconductive and nonlinear optical responses were reported for as-implanted and RTA (rapid thermal annealing) annealed GaAs:As/sup +/. It is expected that the optimum furnace annealing will create arsenic precipitates which can enhance the performance of GaAs:As/sup +/ for photoconductive or nonlinear optical switching applications. The carrier dynamics of furnace-annealed GaAs:As/sup +/ is thus of substantial interests and is the focus of this paper.
When Drug Molecules Look in the Mirror (1996)

Enantiomers possess virtually identical physical properties but often display very different biological activities. Stereochemical non-equivalence, chiral recognition, enantiomer uniqueness, and the preparation of optically active drugs are reviewed. Pertinent information for selected racemic and single enantiomer drugs are provided.
Numerical analysis of a grid array antenna radiating a linearly polarized dual-beam (2015)

The radiation characteristics of a grid array antenna for one-line excitation are investigated using the method of moments. This grid radiates a dual-beam. It is revealed that the co-polarized electric field components are the same in the two principal planes. The direction of maximum radiation and the gain are discussed.
Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities (2014)

The polyamines, spermidine (Spd) and spermine, and their diamine precursor putrescine, are important regulators of various cellular functions, such as proliferation and differentiation. Polyamine homeostasis is tightly regulated on the level of uptake, excretion, biosynthesis, interconversion and terminal catabolism. The rate-controlling enzymes of polyamine biosynthesis and interconversion are ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT), respectively. Here, we describe a protocol to assay ODC (Jänne and Williams-Ashman, 1971) and SSAT (Libby, 1978) activities from cell or tissue samples.
Modelling Anxiety Disorders Following Chemical Exposures (1994)

The effects of kindling and inverse benzodiazepine receptor agonist beta-carbolines on animal models of anxiety are briefly reviewed in relation to affective disorder associated with chemical exposure. Recent experimental results are described. In the present study, cats were given the inverse benzodiazepine receptor agonist, FG-7142, a powerful anxiogenic compound in humans and animals. Neural transmission in pathways involved in defensive behavior in the cat was monitored using evoked potential techniques. Change in these pathways was related to behavioral changes induced by the drug. It was found that a single dose of FG-7142 lastingly increased defensive response to rodents for at least 40 days after drug administration. Behavioral change was specific to defensive response, since approach-attack behavior remained unchanged, replicating previous studies. The benzodiazepine receptor antagonist, Flumazenil, reversed the increase in defensiveness in a drug-dependent manner, replicating previous findings. Increased defensiveness was paralleled by a delayed onset potentiation of neural transmission between the amygdala and the medial hypothalamus of the left hemisphere. Potentiation in the left hemisphere was transient, decaying between 6 and 12 days after the drug. There was a longer lasting potentiation (LTP) of activity evoked in the left and right amygdalo-periacqueductal gray pathways and in the right amygdalo-medial hypothalamic pathway. Potentiation in these pathways appeared at the time of behavioral change. Potentiation of the right amygdalo-periacqueductal gray and right amygdalo-medial hypothalamic pathways persisted until the end of the experiment. In contrast, potentiation of the left amygdalo-periacqueductal gray pathway faded by 40 days after the drug. Flumazenil decreased potentiation ony in the right amygdalo-periacqueductal gray pathway. These data strongly suggest that lasting affective change is mediated by lasting changes in particular efferents of the amygdala of the right hemisphere. Behavioral and physiological effects of FG-7142 were blocked by the N-methyl-D-Aspartate (NMDA) receptor blocker, AP7. The data suggest that failure of neural inhibition induced by FG-7142 engages NMDA receptor processes to produce lasting potentiation of transmission in neural circuits that mediate defensive response with behavioral consequences. Since FG-7142 interferes with GABA mediated neural inhibition and is proconvulsant, its action might mimic the action of other environmental chemicals with similar properties, such as chlorinated hydrocarbon insecticides. The relationship of the present data to the literature on the neural and behavioral effects of insecticide exposure is discussed. The significance of these findings for multiple chemical sensitivity disorder is also briefly discussed.
Expression of <i>Chlamydia pneumoniae</i> Polymorphic Membrane Protein Family Genes (2001)

The genome of the obligate intracellular bacterium Chlamydia pneumoniae CWL029 encodes a family of 21 proteins with predicted outer membrane localization. These polymorphic membrane proteins (Pmps) are heterogeneous in both amino acid sequence and predicted size but are unified by the conserved amino acid motifs GGAI and FXXN repeated in the N-terminal half of each protein. Reverse transcriptase PCR analysis showed that all pmp genes are transcribed. To determine whether all proteins are expressed, specific antisera were generated by immunization with mutually exclusive synthetic peptides representing each of the 21 predicted Pmps. Each antiserum reacted with, and was typically immunospecific for, the corresponding peptide immunogen by enzyme-linked immunosorbent assay. Western blot analyses of purified elementary bodies showed that 11 of the 21 Pmps were detectable. Attempts to demonstrate by Sarykosyl fractionation that the Pmps were localized to the outer membrane revealed that several of the Pmps were unstable and readily degraded. Analyses of additional C. pneumoniae strains showed that although some Pmps are conserved, others vary between strains, in both molecular weight and level of expression.
Cell mates in the superfamily (1994)

Journal Article Cell mates in the superfamily Get access N S Hawa, N S Hawa Search for other works by this author on: Oxford Academic Google Scholar M Hewison, M Hewison Search for other works by this author on: Oxford Academic Google Scholar S M Farrow, S M Farrow Search for other works by this author on: Oxford Academic Google Scholar J L O'Riordan J L O'Riordan Search for other works by this author on: Oxford Academic Google Scholar Endocrinology, Volume 135, Issue 1, 1 July 1994, Pages 1–3, https://doi.org/10.1210/endo.135.1.8013339 Published: 01 July 1994
Sunlight protection in normal skin. By absorptive filter chemically induced in stratum corneum (1966)

The protective effect of a sunscreen filter chemically induced in normal skin was tested by using direct sunlight exposure to assure effectiveness. The topical preparation was applied immediately after mixing. Washing with soap and water did not remove the protective filter. Greater protection resulted from repetitive use or increase of the applied quantity, or both. Separate application of either component of the mixture produced no significant protection in clinical trials and in vitro experiments.
Studies on the mode of antifungal action of pradimicin antibiotics. II. D-mannopyranoside-binding site and calcium-binding site. (1993)

Based on the structure-activity relationship data of BMY-28864 and related pradimicin derivatives, the calcium salt-forming ability and the D-mannopyranoside-specific visible absorption maximum shift of BMY-28864 were analysed in the ternary complex formation of BMY-28864 with D-mannopyranoside and calcium. The free C-18 carboxyl group of BMY-28864 was proved to be the sole site for binding to calcium, while no hydroxyl groups of the aglycone were involved in calcium salt formation. The stereospecific D-mannopyranoside-recognizing ability of BMY-28864 was completely abolished by removal of the C-5 disaccharide moiety, and, more particularly, of the C-5 thomosamine moiety. Close relationship of these findings with the antifungal action was also supported by the in vitro antifungal assay and the potassium leakage induction test.
Low-Power Touch-Sensing Circuit With Reduced Scanning Algorithm for Touch Screen Panels on Mobile Devices (2014)

Touch screen panel (TSP) technology has dramatically enhanced the connectivity between man and machine, in particular within mobile consumer electronics where mobility is a key design criterion. This paper introduces a novel charge-sensing technique derived from the behavioral characteristics of a mutual capacitive touch screen panel. The approach is based on a reduced scan algorithm whereby both the target and its surroundings form the node and the selection process is conducted in two phases. In the first phase, the introduction of a charge on the TSP is sensed, while the second phase evaluates when the touch event occurs on the TSP. The proposed algorithm reduces the number of sensing nodes activated during the waiting period by observing the behavior of a single row within the charge sensing array, as opposed to the more conventional approach in which all TSP nodes are scanned. As a result, power consumption is reduced by 60% during the sensing phase, while the dynamic sensing range is increased by a factor of 38% for a complete two-stage sensing cycle.
How lateral interaction develops in a self-organizing feature map (2002)

A biologically motivated mechanism for self-organizing a neural network with modifiable lateral connections is presented. The weight modification rules are purely activity-dependent, unsupervised, and local. The lateral interaction weights are initially random, but develop into a 'Mexican hat' shape around each neuron. At the same time, the external input weights self-organize to form a topological map of the input space. The algorithm demonstrates how self-organization can bootstrap itself using input information. Predictions of the algorithm agree very well with experimental observations on the development of lateral connections in cortical feature maps.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Silent myocardial ischemia: a special aspect of coronary artery disease (1990)

Summary. Silent myocardial ischemia is a serious progressive disease which deserves continuous surveillance. It is characterized by painless ST-segment depression based on coronary artery disease. The mechanisms responsible for producing this condition do not differ from stable angina pectoris. - The prognostic implications of silent ischemia are not yet completely clarified. However it could be argued that patients die - whether or not angina pectoris is present - because they develop myocardial infarction or ischemic ventricular arrhythmias. Complex ventricular arrhythmias seem to occur not at a higher rate than in patients with angina pectoris. On the other hand there is no doubt about a present arrhythmogenic potential of a silent myocardial ischemia, but there is so far no clinical evidence that the prognostic significance is different to symptomatic myocardial ischemia. - In order to reduce or eliminate ischemic episodes intensive combination medical therapy should be used. If symptoms recur or ischemic changes are persistent, consideration should be given to revascularisation. Nevertheless, the optimal way of treating silent ischemia is still to be defined.
ChemInform Abstract: ASYMMETRIC CATALYSES. PART 4. HYDROGENATION OF PROCHIRAL OLEFINS WITH RHODIUM M COMPLEXES OF OPTICALLY ACTIVE AMIDINES (1980)

Abstract Der Rh‐Komplex (I) liefert mit den optisch aktiven Amidinen (II) oder ihren Li‐Derivaten nach Aktivierung mit H 2 Katalysatoren, mit denen bei Raumtemp. und 1.1 bar H 2 ‐Druck in verschiedenen Lösungsmitteln die prochiralen Substrate (III) sowie die Verbindungen (IV)‐(VI) hydriert werden (Tabellen).