gebhart/patrepeval huggingface dataset:
Could stereopurity reinvigorate the antisense field? (2016)

All new drug technologies live through cycles of hype, disappointment, and realism. But few scientific approaches have gone through as many twists and turns as nucleic acid therapeutics, drugs that use strands of genetic material to tackle the underlying causes of disease. Wave Life Sciences is hoping to break that cycle. The company is founded on the notion that earlier oligonucleotides have a fundamental flaw: They are complex mixtures of hundreds of thousands of stereoisomers. “Nature likes three dimensions,” says Wave’s chief executive officer, Paul Bolno. “The structural integrity of molecules is incredibly important to nature.” Armed with technology to design and manufacture stereopure oligonucleotides, Wave will soon start to roll out data and clinical trials that it hopes provide the first evidence supporting the notion that a single oligonucleotide works better than a mixture. Company watchers, many of whom are skeptics, are eager to see what emerges. Wave emerged
Electron cyclotron wave resonances and power absorption effects in electrodeless low pressure h.f. plasmas with a superimposed static magnetic field (1974)

The density of inductively excited low pressure h.f. plasmas has been measured as a function of a small transverse static magnetic field for various levels of the h.f. power applied to the discharge. Evidence is given for the plasma excitation by the zero and first order electron cyclotron wave resonance. Characteristic differences between the results at low and high h.f. powers are discussed with a simple model of the power absorption by the plasma electrons.
<i>BRAF</i> V600E Is a Determinant of Sensitivity to Proteasome Inhibitors (2013)

A critical step toward defining tailored therapy in patients with cancer is the identification of genetic interactions that may impair-or boost-the efficacy of selected therapeutic approaches. Cell models able to recapitulate combinations of genetic aberrations are important to find drug-genotype interactions poorly affected by the heterogeneous genetics of human tumors. In order to identify novel pharmacogenomic relationships, we employed an isogenic cell panel that reconstructs cancer genetic scenarios. We screened a library of 43 compounds in human hTERT-HME1 epithelial cells in which PTEN or RB1 were silenced in combination with the targeted knockin of cancer-associated mutations in EGFR, KRAS, BRAF, or PIK3CA oncogenes. Statistical analysis and clustering algorithms were applied to display similar drug response profiles and mutation-specific patterns of activity. From the screen, we discovered that proteasome inhibitors show selectivity toward BRAF V600E-mutant cells, irrespective of PTEN or RB1 expression. Preferential targeting of BRAF-mutant cells by proteasome inhibitors was corroborated in a second BRAF V600E isogenic model, as well as in a panel of colorectal cancer cell lines by the use of the proteasome inhibitor carfilzomib. Notably, carfilzomib also showed striking in vivo activity in a BRAF-mutant human colorectal cancer xenograft model. Vulnerability to proteasome inhibitors is dependent on persistent BRAF signaling, because BRAF V600E blockade by PLX4720 reversed sensitivity to carfilzomib in BRAF-mutant colorectal cancer cells. Our findings indicated that proteasome inhibition might represent a valuable targeting strategy in BRAF V600E-mutant colorectal tumors.
IT Colum: A harm reduction programme for drug data users (1997)

"IT Colum: A harm reduction programme for drug data users." Journal of Substance Misuse, 2(1), pp. 3–4
Ring oscillator based embedded structure for decoupling PMOS/NMOS degradation with switching activity replication (2010)

Until recently, negative bias temperature instability (NBTI) has been regarded as the primary reliability concern. However, with the introduction of high-k metal gate stacks, positive bias temperature instability (PBTI) has gradually become equally important. Conventional ring oscillator based structures monitor the delay/frequency through an inverter chain to track the PMOS threshold voltage (Vt) degradation due to NBTI, with the assumption of zero degradation in the NMOS device. Therefore these structures lose their effectiveness in the presence of PBTI. In this work, we propose a ring oscillator based test structure that isolates the Vt degradation in the PMOS device and the NMOS device, hence permitting simultaneous monitoring of both. We also introduce a switching activity replication scheme for more accurate prediction of degradation in actual data paths.
Exploiting Task Intervals for Whole Body Robot Control (2006)

This paper presents a whole body motion algorithm and shows some steps towards its feasibility in complex scenarios. We employ the framework of Liegeois, (1977) which solves the redundant inverse kinematics problem on velocity level. To make the controller suitable for a variety of different applications, task descriptors for the relative effector positions as well as a one-and two-dimensional attitude representation are proposed. The inverse kinematics are extended by allowing for "displacement intervals" which are formulated in task space. The proposed control scheme guarantees that the effector motion lies within the specified interval. However, the motion inside the interval is determined by optimization criteria, which can effectively be utilized to generate a more flexible and robust motion. We discuss an example and show simulation and experimental results on the humanoid robot ASIMO
FEC schemes for ATM traffic over wireless links (2002)

ATM traffic carried over fiber optic links experiences low bit error rates (BER). For this reason, cell error/loss recovery techniques for ATM networks have thus far concentrated on cell losses due to congestion and buffer overflow at network switches. In this paper we analyze a different network scenario, namely ATM networks where the end-to-end link includes wireless media. The BER of these media may be significantly higher than that which only has optical fiber links. In addition, errors will occur in bursts and thus with high probability will overwhelm the error correcting capability of the header error control (HEC) in the ATM header. Due to the high bandwidth-delay product of the channel, pure ARQ schemes for cell error/loss recovery would be inefficient. Thus an FEC or hybrid FEC/ARQ scheme is needed to achieve acceptable cell loss rate for a given application. We analyze a concatenated FEC scheme with byte-level interleaving with a RS outer code and a convolutional inner code, and study its performance in AWGN and on a Rayleigh fading channel. We also present the throughput and delay (due to retransmission) performance of a hybrid FEC/ARQ scheme over the same channel model. The authors discuss satellite and mobile radio links as examples.
A low-complexity, reduced-power Viterbi Algorithm (1999)

We present two memory-, process- and power-efficient algorithmic transformations for the Viterbi Algorithm (VA). The first performs in-place computations reducing memory required and bit transitions on the data address bus, while the second simplifies the traceback routine of the VA.
Sensitive Wavelength Dependence of PdC and Pd Formation from Photolysis of Bis(hexafluoroacetylacetonato)palladium(II) [<i>J. Am. Chem. Soc.</i> <b>2000</b>, <i>122</i>, 1227−1228]. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionSensitive Wavelength Dependence of PdC and Pd Formation from Photolysis of Bis(hexafluoroacetylacetonato)palladium(II) [J. Am. Chem. Soc.2000, 122, 1227−1228].Peter Muraoka, Daniel Byun, and Jeffrey I. ZinkCite this: J. Am. Chem. Soc. 2000, 122, 23, 5670Publication Date (Web):May 27, 2000Publication History Published online27 May 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/ja004649fhttps://doi.org/10.1021/ja004649fcorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views290Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (10 KB) Get e-Alertsclose Get e-Alerts
Tissue-specific Expression Patterns and Fine Mapping of the Human Kallikrein (KLK) Locus on Proximal 19q13.4 (2000)

The tissue or glandular kallikreins (KLK) are members of a highly conserved multigene family encoding serine proteases that are central to many biological processes. The rodent KLK families are large, highly conserved and clustered at one locus. The human KLK gene family is clustered on chromosome 19q13.3-13.4, and until recently consisted of just three members. However, recent studies have identified up to 11 new members of the KLK family that are less conserved than their rodent counterparts. Using a Southern blot and sequence analysis of 10 BACs and cosmids spanning approximately 400 kilobases (kb) either side of the original KLK 60-kb locus, we demonstrated that these genes also lie adjacent to this. We have also clarified the position of several microsatellite markers in relation to the extended KLK locus. Moreover, from Southern blot analysis of the cosmids and BACs with a degenerate oligonucleotide probe to the histidine-encoding region of serine proteases, we have shown that there are no other serine protease genes approximately 400 kb centromeric and 220 kb telomeric of the extended locus. We performed an extensive analysis of the expression patterns of these genes by poly(A)(+) RNA dot blot and reverse transcriptase-polymerase chain reaction analysis, and demonstrated a diverse pattern of expression. Of interest are clusters of genes with high prostate (KLK2-4) and pancreatic (KLK6-13) expression suggesting evolutionary conservation of elements conferring tissue specificity. From these findings, it is likely that the human KLK gene family consists of just 14 clustered genes within 300 kb and thus is of a comparable size to the rodent families (13-24 genes within 310 and 480 kb, respectively). In contrast to the rodent families, the newest members of the human KLK family are much less conserved in sequence (23-44% at the protein level) and appear to consist of at least four subfamilies. In addition, like the rat, these genes are expressed at varying levels in a diverse range of tissues although they exhibit quite distinct patterns of expression.
Synthesis of long chain fatty acids esterified onto cellulose via the vacuum-acid chloride process (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of long chain fatty acids esterified onto cellulose via the vacuum-acid chloride processHarpreet S. Kwatra, James M. Caruthers, and Bernard Y. TaoCite this: Ind. Eng. Chem. Res. 1992, 31, 12, 2647–2651Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ie00012a004https://doi.org/10.1021/ie00012a004research-articleACS PublicationsRequest reuse permissionsArticle Views609Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Survey of Scientific Approaches Considering the Integration of Security and Risk Aspects into Business Process Management (2009)

In the past years, regulative bodies have obliged a more stringent consideration of risk and security management. This development forced companies to apply risk, security and business process management in a more integrated way. Simultaneously, it can be observed that the scientific community intensified research activities in this integrative domain. Within this survey paper we examine scientific research efforts in the field of security and risk related business process/workflow management. Therefore we survey nine representative approaches and identify research challenges in this area.
Neuroma de Morton (2015)

espanolEl neuroma de Morton es una fibrosis perineural, que causa un gran numero de metatarsalgias. Es una neuropatia por compresion y degeneracion que afecta a las ramas interdigitales. Se puede dar en cualquier espacio interdigital aunque es mas comun en el tercer espacio. Suele aparecer sobre los 40 anos y es mas habitual en mujeres, principalmente bilateral. Comunmente es conocido como neuroma de Morton, pero esto es incorrecto porque un neuroma es el tumor de un nervio, y se trata de una fibrosis perineural. El diagnostico esta basado fundamentalmente en los hallazgos clinicos y se puede conseguir con la simple exploracion aunque estudios complementarios como la RMN y la ecografia pueden confirmar el diagnostico. El tratamiento lo determinara el tiempo desde que se instaura el neuroma y se evaluara en la etapa del desarrollo en la que se encuentra. El tipo de tratamiento variara segun la gravedad de su problema. Antes de llegar a una cirugia,que no siempre tiene los resultados esperados, se deben agotar otras alternativas como tratamiento conservador ya que resulta eficaz en casi un 70% de los casos. EnglishMorton’s neuroma is a perineural fibrosis causing a large number of metatarsalgias. It is a compression and degeneration neuropathy affecting interdigital nerve conductions. It may appear in any interdigital space although it is very common in the third space. It usually appears at around 40 years of age and it is more commonly found in women, especially the bilateral one. The diagnosis is principally based on clinical findings and it can be achieved with a simple exploration even if complementary studies as the NMR and medical ultrasonography can confirm the diagnosis. The treatment will be determined by the time since the neuroma is established and it will be evaluated in the phase of development in which it is found.The type of treatment will vary according to the seriousness of the problem.
Development of All New 7-speed Automatic Transmission for RWD Vehicles (2009)

<div class="htmlview paragraph">JATCO developed an all new 7-speed automatic transmission (AT) for front engine rear wheel drive medium and large vehicles. This transmission features high torque capacity, downsizing, and innovative technology to realize fuel economy improvement. In addition, it offers excellent driveability and shift responsiveness for maximum driver satisfaction and pleasibility. Specifically, the new lock-up system and adaptive shift controls add value in terms of “Joy of Driving” while providing a 7% improvement in fuel economy over the 5 speed AT it replaces.</div>
Enhancing the Sensitivity and Resolution of Multi-ECT Probe for Inspection of Printed Circuit Boards. (2003)

Eddy-current testing (ECT) inspection is an attractive approach for detecting trace damage on as-fabricated printed circuit boards (PCBs). The distinctive features of this approach are its non-contact method and conductive testing by induced eddy currents. We propose several kinds of planar-type probes with a meander exciting coil and discuss detection characteristics.This paper reports the structure and scanning of a probe that enhances the sensitivity and resolution of inspection. Results show that wiring, soldering points, and damage can be imaged on a two-dimensional plane. Disconnections can be detected on printed wiring with 0.2-mm width.
Accurate Transient Response Model for Automatic Synthesis of High-Speed Operational Amplifiers (2006)

This paper presents an accurate time-domain analysis of operational amplifiers' step response. Both slewing and linear settling phases are investigated in order to correct some discrepancies found in previous literature works. Moreover theoretical results are exploited developing a CAD tool for the automatic synthesis of high-gain highspeed operational amplifiers. Transistor level simulations are performed with MOS lev. 2 and BSIM3v3 models for a telescopic OTA evaluated in the design of a 12-b 200-MS/s pipelined analog-to-digital converter in a 0.35-/spl mu/m BiCMOS technology. The excellent agreement between predicted and simulated results are the consequence of an improved analysis of the slewing-to-linear transition.
A NURBS-based vector muscle model for generating human facial expressions (2004)

In this paper, a novel method based on nonuniform rational B-spline (NURBS) curves is proposed to simulate a physics-based muscle model for facial expression animation. In our system, nonuniform rational B-spline curves are used to construct facial muscles based on the anatomical knowledge. By changing the weights of the NURBS curves, we can form a motion vector to control facial muscle movements. With different number of control points, muscles are more controllable so that more detailed facial expression and mouth shapes can be simulated. Our approach can simulate different types of muscles including linear and sphincter muscles, as well as the nonlinear part of the face like fatty tissue.
<i>Ex vivo</i> evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application (1999)

Efficient and safe heparin anticoagulation has remained a problem for continuous renal replacement therapies and intermittent hemodialysis for patients with acute renal failure. To make heparin therapy safer for the patient with acute renal failure at high risk of bleeding, we have proposed regional heparinization of the circuit via an immobilized heparinase I filter. This study tested a device based on Taylor-Couette flow and simultaneous separation/reaction for efficacy and safety of heparin removal in a sheep model. Heparinase I was immobilized onto agarose beads via cyanogen bromide activation. The device, referred to as a vortex flow plasmapheretic reactor, consisted of two concentric cylinders, a priming volume of 45 ml, a microporous membrane for plasma separation, and an outer compartment where the immobilized heparinase I was fluidized separately from the blood cells. Manual white cell and platelet counts, hematocrit, total protein, and fibrinogen assays were performed. Heparin levels were indirectly measured via whole-blood recalcification times (WBRTs). The vortex flow plasmapheretic reactor maintained significantly higher heparin levels in the extracorporeal circuit than in the sheep (device inlet WBRTs were 1. 5 times the device outlet WBRTs) with no hemolysis. The reactor treatment did not effect any physiologically significant changes in complete blood cell counts, platelets, and protein levels for up to 2 hr of operation. Furthermore, gross necropsy and histopathology did not show any significant abnormalities in the kidney, liver, heart, brain, and spleen.
Sphingosine‐1‐Phosphate is Involved in the Occlusive Arteriopathy of Pulmonary Arterial Hypertension (2016)

Despite several advances in the pathobiology of pulmonary arterial hypertension (PAH), its pathogenesis is not completely understood. Current therapy improves symptoms but has disappointing effects on survival. Sphingosine-1-phosphate (S1P) is a lysophospholipid synthesized by sphingosine kinase 1 (SphK1) and SphK2. Considering the regulatory roles of S1P in several tissues leading to vasoconstriction, inflammation, proliferation, and fibrosis, we investigated whether S1P plays a role in the pathogenesis of PAH. To test this hypothesis, we used plasma samples and lung tissue from patients with idiopathic PAH (IPAH) and the Sugen5416/hypoxia/normoxia rat model of occlusive PAH. Our study revealed an increase in the plasma concentration of S1P in patients with IPAH and in early and late stages of PAH in rats. We observed increased expression of both SphK1 and SphK2 in the remodeled pulmonary arteries of patients with IPAH and PAH rats. Exogenous S1P stimulated the proliferation of cultured rat pulmonary arterial endothelial and smooth-muscle cells. We also found that 3 weeks of treatment of late-stage PAH rats with an SphK1 inhibitor reduced the increased plasma levels of S1P and the occlusive pulmonary arteriopathy. Although inhibition of SphK1 improved cardiac index and the total pulmonary artery resistance index, it did not reduce right ventricular systolic pressure or right ventricular hypertrophy. Our study supports that S1P is involved in the pathogenesis of occlusive arteriopathy in PAH and provides further evidence that S1P signaling may be a novel therapeutic target.
Introduction to Biomechanics of the Cornea (1992)

While work remains to be done in this area, it is seen that useful and predictive models can be created which significantly improve our understanding and predictability of corneal procedures.
AM-FM Car Radio for Tomorrow (1980)

A new AM-FM monolithic integrated circuit for application in car radio is described with a particular emphasis on those points that are very critical for such an application.