gebhart/patrepeval huggingface dataset:
A fast matched filter in time domain (2004)

This paper presents a fast matched filter algorithm in time domain. Matched filters compute correlation of signals for optimal detection of signals in noise, for extracting ranging measurements, synchronisation, etc. We consider matched filters in the context of Global Positioning System (GPS) receivers, but the algorithms presented here can be used for other applications as no constraining assumptions are made in derivations. Our method outperforms conventional time domain method several times in arithmetic complexity. It is also competitive with transform domain techniques based on Fast Fourier Transform (FFT). Unlike FFT based methods our approach is accurate and is not using rounding and scaling operations.
Manufacturing System Design: Tradeoff Curve Analysis (1995)

Includes bibliographical references (p. 32-33).
The Effectiveness and Efficiency of Agglomerative Hierarchic Clustering in Document Retrieval (1985)

ABSTRACT NOT SUPPLIED
Herbal Medicinals (1998)

Herbal medicinals are being used by an increasing number of patients who typically do not advise their clinicians of concomitant use. Known or potential drug-herb interactions exist and should be screened for. If used beyond 8 weeks, Echinacea could cause hepatotoxicity and therefore should not be used with other known hepatoxic drugs, such as anabolic steroids, amiodarone, methotrexate, and ketoconazole. However, Echinacea lacks the 1,2 saturated necrine ring associated with hepatoxicity of pyrrolizidine alkaloids. Nonsteroidal anti-inflammatory drugs may negate the usefulness of feverfew in the treatment of migraine headaches. Feverfew, garlic, Ginkgo, ginger, and ginseng may alter bleeding time and should not be used concomitantly with warfarin sodium. Additionally, ginseng may cause headache, tremulousness, and manic episodes in patients treated with phenelzine sulfate. Ginseng should also not be used with estrogens or corticosteroids because of possible additive effects. Since the mechanism of action of St John wort is uncertain, concomitant use with monoamine oxidase inhibitors and selective serotonin reuptake inhibitors is ill advised. Valerian should not be used concomitantly with barbiturates because excessive sedation may occur. Kyushin, licorice, plantain, uzara root, hawthorn, and ginseng may interfere with either digoxin pharmacodynamically or with digoxin monitoring. Evening primrose oil and borage should not be used with anticonvulsants because they may lower the seizure threshold. Shankapulshpi, an Ayurvedic preparation, may decrease phenytoin levels as well as diminish drug efficacy. Kava when used with alprazolam has resulted in coma. Immunostimulants (eg, Echinacea and zinc) should not be given with immunosuppressants (eg, corticosteroids and cyclosporine). Tannic acids present in some herbs (eg, St John wort and saw palmetto) may inhibit the absorption of iron. Kelp as a source of iodine may interfere with thyroid replacement therapies. Licorice can offset the pharmacological effect of spironolactone. Numerous herbs (eg, karela and ginseng) may affect blood glucose levels and should not be used in patients with diabetes mellitus.
Detection of the Survival Motor Neuron (SMN) Genes by FISH: Further Evidence for a Role for SMN2 in the Modulation of Disease Severity in SMA Patients (1999)

Spinal muscular atrophy (SMA) is a common autosomal recessive neuromuscular disorder which presents with various clinical phenotypes ranging from severe to very mild. All forms are caused by the homozygous absence of the survival motor neuron ( SMN1 ) gene. SMN1 and a nearly identical copy ( SMN2 ) are located in a duplicated region at 5q13 and encode identical proteins. The genetic basis for the clinical variability of SMA remains unclear, but it has been suggested that the copy number of SMN2 could influence the disease severity. We have assessed the number of SMN2 genes in patients with different clinical phenotypes by fluorescence in situ hybridization (FISH) using as SMN probe a mixture of small specific DNA fragments. Gene copy number was established by FISH on interphase nuclei, but the presence of two SMN2 genes on the same chromosome could also be revealed by FISH on metaphase spreads. All patients had at least two SMN2 genes. We found two or three copies of SMN2 in severely affected type I patients, three copies in intermediately affected type II patients, generally four copies in mildly affected type III patients and four or eight copies in patients with very mild adult-onset SMA. No alterations of the genes were detected by Southern blot and sequence analysis, suggesting that all gene copies of SMN2 were intact. These data provide additional evidence that the SMN2 genes modulate the disease severity and suggest that knowledge of the gene copy number could be of some prognostic value.
Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells (2010)

Diabetes is a profound disease that results in a severe lack of regulation of systemic salt and water balance. From our earlier work on the endocrine regulation of salt taste at the level of the epithelial sodium channel (ENaC), we have begun to investigate the ability of insulin to alter ENaC function with patch-clamp recording on isolated mouse taste receptor cells (TRCs). In fungiform and vallate TRCs that exhibit functional ENaC currents (e.g., amiloride-sensitive Na(+) influx), insulin (5-20 nM) caused a significant increase in Na(+) influx at -80 mV (EC(50) = 7.53 nM). The insulin-enhanced currents were inhibited by amiloride (30 μM). Similarly, in ratiometric Na(+) imaging using SBFI, insulin treatment (20 nM) enhanced Na(+) movement in TRCs, consistent with its action in electrophysiological assays. The ability of insulin to regulate ENaC function is dependent on the enzyme phosphoinositide 3-kinase since treatment with the inhibitor LY294002 (10 μM) abolished insulin-induced changes in ENaC. To test the role of insulin in the regulation of salt taste, we have characterized behavioral responses to NaCl using a mouse model of acute hyperinsulinemia. Insulin-treated mice show significant avoidance of NaCl at lower concentrations than the control group. Interestingly, these differences between groups were abolished when amiloride (100 μM) was added into NaCl solutions, suggesting that insulin was regulating ENaC. Our results are consistent with a role for insulin in maintaining functional expression of ENaC in mouse TRCs.
A comprehensive taxonomy for multi-robot task allocation (2013)

Task allocation is an important aspect of many multi-robot systems. The features and complexity of multi-robot task allocation (MRTA) problems are dictated by the requirements of the particular domain under consideration. These problems can range from those involving instantaneous distribution of simple, independent tasks among members of a homogenous team, to those requiring the time-extended scheduling of complex interrelated multi-step tasks for members of a heterogenous team related by several constraints. The existing widely used taxonomy for task allocation in multi-robot systems was designed for problems with independent tasks and does not deal with problems with interrelated utilities and constraints. While that taxonomy was a ground-breaking contribution to the MRTA literature, a survey of recent work in MRTA reveals that it is no longer a sufficient taxonomy, due to the increasing importance of interrelated utilities and constraints in realistic MRTA problems under consideration. Thus, in this paper, we present a new, comprehensive taxonomy, iTax, that explicitly takes into consideration the issues of interrelated utilities and constraints. Our taxonomy maps categories of MRTA problems to existing mathematical models from combinatorial optimization and operations research, and hence draws important parallels between robotics and these fields.
Oracle-guided component-based program synthesis (2010)

We present a novel approach to automatic synthesis of loop-free programs. The approach is based on a combination of oracle-guided learning from examples, and constraint-based synthesis from components using satisfiability modulo theories (SMT) solvers. Our approach is suitable for many applications, including as an aid to program understanding tasks such as deobfuscating malware. We demonstrate the efficiency and effectiveness of our approach by synthesizing bit-manipulating programs and by deobfuscating programs.
Sarcolectin: an interferon antagonist extracted from hamster sarcomas and normal muscles. Isolation, characterization, and purification. (1983)

In the present work we show that sarcoma and normal hamster tissues contain a protein which agglutinates normal and transformed cells. The inhibition of agglutination by galacturonic acid and occasionally by fucose suggests a resemblance of this protein with vegetal lectins. When added 5 h after interferon, the crude semipurified and electrophoretically homogeneous preparations reduce within 20 h the antiviral state pre-established by interferon. These two biological tests have enabled us to monitor the subsequent purification steps. The isolation of the biologically active protein is greatly facilitated by its resistance to pepsin and nucleases, whereas its sensitivity to trypsin and Pronase suggests its proteinaceous character. Furthermore, the molecule is stable when heated 1-2 min at 100 degrees C in the presence or absence of sodium dodecyl sulfate. After pepsin treatment, Sephacryl G-200 gel filtration, and ion exchange chromatography on DEAE-cellulose, 25-40-fold purification can be obtained. When controlled by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, a double band (DEAE-cellulose sample) or single band (octyl-agarose sample) is detected in the 65,000-dalton region and no other contaminator is present. The eluted protein retains full biological activity when assayed by the degradation of the interferon-induced antiviral protection in the cell or titrated by cell agglutination.
Optimal Tx-BF for MIMO SC-FDE Systems (2013)

Transmit beamforming (Tx-BF) for multiple-input multiple-output (MIMO) channels is an effective means to improve system performance. In frequency-selective channels, Tx-BF can be implemented in combination with single-carrier frequency-domain equalization (SC-FDE) to combat inter-symbol interference. In this paper, we consider the optimal design of the Tx-BF matrix for a MIMO SC-FDE system employing a linear minimum mean square error (MSE) receiver. We formulate the Tx-BF optimization problem as the minimization of a general function of the stream MSEs, subject to a transmit power constraint. The optimal structure of the Tx-BF matrix is obtained in closed form and an efficient algorithm is proposed for computing the optimal power allocation. Our simulation results validate the excellent performance of the proposed scheme in terms of uncoded bit-error rate and achievable bit rate.
General near‐zone light source model and its application to computer‐automated reflector design (1996)

The goal of this work is to develop a general light source model that is physically accurate, intuitively descriptive, computationally convenient, and applicable to real sources. It solves two major problems in illumination optics: near zone general extended light source charac- terization for accurate image rendering and ray tracing, and computer- automated reflector design using the resulting near-zone model. The main approach is to combine measurements with Fourier analysis, using judiciously chosen coordinate systems and orthogonal fitting functions. This has several advantages over standard ray tracing: it provides for natural data compression and interpolation; it bypasses the problem of computing the radiance distribution of a real source by using actual pin- hole CCD camera measurements; and it eliminates the computationally intensive ray-filament intersection problem by transforming the source into an equivalent nonuniform spherical radiator. A method for treating the occlusion of rays by the extended filament, with only spherical inter- section calculations, is also discussed. The application of the method is illustrated by the problem of designing a smooth specular reflector to cast a desired intensity distribution on a distant screen for a given source. The problem becomes a straightforward numerical optimization of the perturbations to a base reflector shape. An algorithm to provide a first guess for the perturbations based on the shape of the image perim- eter is also described. © 1996 Society of Photo-Optical Instrumentation Engineers. Subject terms: near-zone light source model; computer-automated reflector de- sign.
Degradation mechanisms of mechanical connectors on aluminium conductors (1973)

The factors which affect the performance of mechanical connectors for use on aluminium power cables have been investigated. The initial resistance depends upon surface roughness, mechanical load and degree of plastic deformation. The stability of resistance has been studied under conditions of mechanical-load cycling, stress relaxation, interface oxidation, temperature cycling and current loading. The conditions for designing stable mechanical connectors for use on aluminium conductors are given, and the stability of connectors satisfying these conditions has been illustrated by current-cycling measurements.
Muscle fiber types and function. (1992)

A major recent advance in the field of muscle fiber types has been the discovery that myogenic factors regulate fiber phenotypic properties. Myogenic influences occur in limb and trunk (somitic) muscle, but are particularly strong in jaw-closing muscles and extraocular muscles that express some unique myofibrillar proteins. In somitic muscles, a variant of fast fiber has been discovered, making four types of fibers: I, IIA, IIX, and IIB. These fibers express different isoforms of myofibrillar and other proteins. The speed and power of the four types of fibers are distinct and are controlled principally by their myosin heavy chains, which modulate the two regulatory steps in the crossbridge cycle, one controlling the rate of development of force, the other controlling the maximal velocity of shortening. Fast fibers have a higher threshold for Ca(2+)-activated force and a steeper force-pCa relation than do slow fibers. This difference is largely attributable to the cooperativity in the attachment of crossbridges and to the difference in Ca2+ binding capacity of their troponin C. Ca2+ initiates force development in muscle by increasing the rate of attachment of crossbridges. The phosphorylation of myosin light chain enhances this action. This effect of phosphorylation underlies the phenomenon of posttetanic potentiation of the isometric twitch in fast fibers.
First report of <i>Wheat streak mosaic virus</i> in Australia (2003)

In August 2002, wheat plants in glasshouses at the CSIRO Plant Industry Black Mountain laboratories, Canberra, showed symptoms typical of Wheat streak mosaic virus (WSMV) (Murray et al., 1998). In early 2003, similar symptoms were observed on a summer field experiment at the Ginninderra experimental station, Canberra. The symptoms were characterized by a streaking or mottling of the leaves, leading to chlorosis and in some cases very severe stunting of the plant. In many cases the plants were sterile or produced shriveled seed. Affected plants sometimes showed a curling of the leaf; a symptom caused by the wheat curl mite (Aceria tosichella), the vector of WSMV (B. Halliday, 2003, CSIRO Entomology, ACT 2601, Australia, personal communication). RT-PCR tests were used to confirm the presence of WSMV according to the methods of French & Robertson (1994). Following agarose gel electrophoresis, a band of the expected size (271 bp) was amplified from diseased wheat, but not from healthy wheat or a barley control. The sequence of the RT-PCR product was compared with other WSMV sequences in the GenBank database and was found to have over 95% homology. Additional confirmation was obtained by ELISA using a kit for the detection of WSMV (Agdia Inc., Elkhart, IN, USA). Diseased plant samples gave a positive reaction, while that of the healthy wheat control was negative. These results provide the first evidence of WSMV in Australia. Since the discovery of WSMV in Canberra, the virus has been identified in other states, suggesting that it arrived in Australia some years ago, but had remained undetected.
Clean-Chemistry Synthesis of 2-Tetralones in a Single-Stage Acylation−Cycloalkylation Process (2001)

The preparation of substituted-2-tetralones by direct reaction of a 1-alkene with a substituted phenylacetic acid in a reaction system of trifluoroacetic anhydride (TFAA) and phosphoric acid is described. This single-stage process involves in situ formation of a mixed anhydride of the phenylacetic acid and acylation of the alkene by this species followed by cycloalkylation of the aromatic ring. This is a cleaner approach to the synthesis of 2-tetralones compared to Friedel-Crafts aliphatic acylation-cycloalkylation in that use of thionyl chloride, aluminum trichloride, and a chlorinated hydrocarbon solvent is eliminated. In addition, the atom efficiency is augmented by recovery of the spent TFAA as trifluoroacetic acid (TFA) and conversion of this back to TFAA by dehydration.
High accuracy UWB localization in dense indoor environments (2008)

UWB communication and localization systems have many inherent advantages for robust performance in dense, indoor multipath environments. Although UWB systems have been designed for numerous industrial applications, there exists the need for short range (i.e. 5-10 m) UWB localization systems with accuracy an order of magnitude higher (i.e. mm-range) than existing commercial systems. Many system level challenges must be overcome to achieve accuracy on the order of tens of picoseconds, such as high Rx sampling rate, Tx-Rx LO phase noise, Tx-Rx pulse repetition frequency clock phase noise, Rx-induced jitter from sequential sampling, Rx-side calibration of phase offsets in I and Q channels, multipath interference due to dense indoor environments, etc. A detailed system level simulation is setup in order to quantify the contribution of these effects on overall system accuracy. Simulation results are used to highlight these system level errors and show how they can be mitigated.
Control of Aflatoxin Production During Fermentation of Wild Rice (1975)

The effect of water content of wild rice on aflatoxin production by Aspergillus flavus growing in the rice during fermentation, and influences of processing steps as means to reduce aflatoxin contamination were investigated. Aflatoxin was either not detected or rarely observed during 31 days of storage when rice saturated with water or adjusted to contain 33% water was inoculated with spores of A. flavus and stored at 25 C. Detectable amounts of aflatoxin developed in rice maintained at 20% moisture. Aflatoxin B1 content of contaminated fermented wet wild rice was reduced by parching. Aflatoxin analyses of hulls and kernels from parched rice indicated that most of the aflatoxin B1 remained in the hulls; however, detectable amounts of aflatoxin B1 were present in hulled rice kernels. When wild rice was sterilized with ethylene oxide, saturated with water, stored at 25 C, and inoculated with A. flavus, the mold grew if the rice was mixed daily, but only 10 ppb aflatoxin appeared after 19 days of storage. A. flavus did not grow in similarly treated rice that was not mixed.
Suppressor T Cells for IgE and IgG in Peyer's Patches of Mice Made Tolerant by the Oral Administration of Ovalbumin (1978)

A single oral dose of ovalbumin (Ov) resulted in inhibition of IgE formation in mice subsequently immunized i.p. with Al(OH)3-Ov. Repeated feeding of Ov (on alternate days for 2 weeks) induced the formation of detectable suppressor cells in Peyer's patches and spleen. Suppression was demonstrated by the ability of adoptively transferred Peyer's patch or splenic lymphocytes from Ov-fed tolerant mice to inhibit IgE formation in Ov-immunized syngeneic recipients. Suppressor cells could be induced by feeding mice as little as 100 microgram of Ov on alternate days for 2 weeks. Suppression was specific and Peyer's patch lymphocytes were shown to be more effective suppressors than splenic lymphocytes.
Serological tests for the diagnosis of active tuberculosis: relevance for India. (2012)

Diagnostic tests for active tuberculosis (TB) based on the detection of antibodies (serological tests) have been commercially available for decades, although no international guidelines have recommended their use. An estimated 1.5 million serological TB tests, mainly enzyme-linked immunosorbent assays, are performed in India alone every year, mostly in the private sector. The cost of serological tests in India is conservatively estimated at US $15 million (825 million) per year. Findings from systematic reviews on the diagnostic accuracy of serological tests for both pulmonary and extra-pulmonary TB suggest that these tests are inaccurate and imprecise. A cost-effectiveness modelling study suggests that, if used as a replacement test for sputum microscopy, serology would increase costs to the Indian TB control sector approximately 4-fold and result in fewer disability-adjusted life years averted and more false-positive diagnoses. After considering all available evidence, the World Health Organization issued a strong recommendation against the use of currently available commercial serological tests for the diagnosis of TB disease. The expanding evidence base continues to demonstrate that the harms/risks of serological tests far outweigh the benefits. Greater engagement of the private sector is needed to discontinue the use of serological tests and to replace these tests with WHO-endorsed new diagnostics in India. The recent ban on import or sale of TB serological tests by the Indian health ministry is a welcome step in the right direction.
A GPU-based Algorithm for Estimating 3D Geometry and Motion in Near Real-time (2006)

Real-time 3D geometry and motion estimation has many important applications in areas such as robot navigation and dynamic image-based rendering. A novel algorithm is proposed in this paper for estimating 3D geometry and motion of dynamic scenes based on captured stereo sequences. All computations are conducted in the 2D image space of the center view and the results are represented in forms of disparity maps and disparity flow maps. A dynamic programming based technique is used for searching global optimal disparity maps and disparity flow maps under an energy minimization framework. To achieve high processing speed, most operations are implemented on the Graphics Processing Units (GPU) of programmable graphics hardware. As a result, the derived algorithm is capable of producing both 3D geometry and motion information for dynamic scenes in near real-time. Experiments on two trinocular stereo sequences demonstrate that the proposed algorithm can handle scenes that contain non-rigid motion as well as those captured by moving cameras.
Motherese detection based on segmental and supra-segmental features (2008)

In this paper, we present an automatic motherese detection system for the study of parent-infant interaction analysis. Motherese is a speech register directed towards infants and it is characterized by higher pitch, slower tempo, and exaggerated intonation. The goal of this paper is to propose and evaluate different approaches for the detection of motherese from home movies. We investigated the characterization by supra-segmental features (prosody) but also by segmental ones namely the MFCC (Mel Frequency Cepstral Coefficients). Concerning the classification stage, we investigated two different methods: the k-nn (k-nearest neighbors) and the GMM (Gaussian Mixture Models). Experimental results show that segmental features play a major role on the detection.