gebhart/patrepeval huggingface dataset:
Hepatocyte growth factor and its receptor c-met in multiple myeloma (1996)

We have examined whether the hepatocyte growth factor (HGF)/c-met receptor-ligand pair is expressed in freshly isolated and highly purified myeloma cells and whether HGF can be found in the sera of myeloma patients. Myeloma cells were purified with an immunomagnetic method using the syndecan 1-specific antibody B-B4. HGF and c-met mRNA in these cells were examined by reverse transcriptase-polymerase chain reaction (RT-PCR). HGF and c-met proteins were detected by enzyme-linked immunosorbent assay (ELISA) and Western blot, respectively. Serum from 13 myeloma patients was obtained at diagnosis and the levels of HGF were determined by ELISA. HGF and c-met mRNA were expressed in all examined samples (n = 7). HGF was detected in the supernatants of 17 of 20 primary cultures of myeloma cells, whereas bone marrow mononuclear cells from normal controls did not produce detectable amounts of HGF (n = 3). The mean HGF level in serum of myeloma patients at diagnosis was more than fourfold higher than the mean level in normal controls. Possible implications of HGF/c-met expression for the pathophysiology of multiple myeloma are discussed.
Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis (2005)

The Mus81-Eme1 endonuclease is implicated in the efficient rescue of broken replication forks in Saccharomyces cerevisiae and Schizosaccharomyces pombe. We have used gene targeting to study the function of the Mus81-Eme1 endonuclease in mammalian cells. Mus81-deficient mice develop normally and are fertile. Surprisingly, embryonic fibroblasts from Mus81(-/-) animals fail to proliferate in vitro. This proliferation defect can be rescued by expression of the papillomavirus E6 protein that promotes degradation of p53. When grown in culture, Mus81(-/-) cells have elevated levels of DNA damage, acquire chromosomal aberrations, and are hypersensitive to agents that generate DNA cross-links. In contrast to the situation in yeast, murine Mus81 is not required for replication restart following camptothecin treatment. Mus81(-/-) mice and cells are hypersensitive to DNA cross-linking agents. Cross-link-induced double-strand break formation is normal in Mus81(-/-) cells, but the resolution of repair intermediates is not. The persistence of Rad51 foci in Mus81(-/-) cells suggests that Mus81 acts at a late step in the repair of cross-link-induced lesions. Despite these defects, Mus81(-/-) mice do not show increased predisposition to lymphoma or any other malignancy in the first year of life.
Structure of the capsular polysaccharide of <i>Actinobacillus pleuropneumoniae</i> serotype 5b (1992)

The capsular polysaccharide of Actinobacillus pleuropneumoniae serotype 5b (strain L20) was found to be a high molecular mass polymer composed of 2-acetamido-2-deoxy-D-glucose, D-glucose, and 3-deoxy-D-manno-octulosonic acid (KDO). Methylation analysis, partial hydrolysis and a combination of homonuclear and 1H-detected heteronuclear shift-correlated nuclear magnetic resonance experiments showed the polysaccharide to be a branched polymer of a trisaccharide repeating unit, having the structure: [formula; see text]
Lipoxins: resolutionary road (2009)

The resolution of inflammation is an active process controlled by endogenous mediators with selective actions on neutrophils and monocytes. The initial phase of the acute inflammatory response is characterized by the production of pro-inflammatory mediators followed by a second phase in which lipid mediators with pro-resolution activities may be generated. The identification of these mediators has provided evidence for the dynamic regulation of the resolution of inflammation. Among these endogenous local mediators of resolution, lipoxins (LXs), lipid mediators typically formed during cell-cell interaction, were the first to be recognized. More recently, families of endogenous chemical mediators, termed resolvins and protectins, were discovered. LXs and aspirin-triggered LXs are considered to act as 'braking signals' in inflammation, limiting the trafficking of leukocytes to the inflammatory site. LXs are actively involved in the resolution of inflammation stimulating non-phlogistic phagocytosis of apoptotic cells by macrophages. Furthermore, LXs have emerged as potential anti-fibrotic mediators that may influence pro-fibrotic cytokines and matrix-associated gene expression in response to growth factors. Here, we provide a review and an update of the biosynthesis, metabolism and bioactions of LXs and LX analogues, and the recent studies on their therapeutic potential as promoters of resolution and fibro-suppressants.
Computerized Mappings of the Cerebral Cortex: A Multiresolution Flattening Method and a Surface-Based Coordinate System (1996)

Abstract We present a new method for generating two-dimensionnl maps of the cerebral cortex. Our computerized, two-stage flattening method takes as its input any well-defined representation of a surface within the three-dimensional cortex. The first stage rapidly converts this surface to a topologically correct two-dimensional map. without regard for the amount of distortion introduced. The second stage reduces distortions using a multiresolution strategy that makes gross shape changes on a coarsely sampled map and further shape refinements on progressively finer resolution maps. We demonstrate the utility of this approach by creating flat maps of the entire cerebral cortex in the macaque monkey and by displaying various types of experimental data on such maps. We also introduce a surface-based coordinate system that has advantages over conventional stereotaxic coordinates and is relevant to studies of cortical organization in humans as well as non-human primates. Together, these methods provide an improved basis for quantitative studies of individual variability in cortical organization.
The design of an error-free data transmission system for telephone circuits (1961)

Recent experimental results verify that easily implemented codes can detect essentially all errors occurring in digital data sent over toll-grade telephone circuits. A 2-way communications system uses these codes, first to find and then to request a retransmission of any data in error. The feedback logic is detailed herein, and the buffer required to adapt the system to various data sources is discussed. Extrapolated experimental results indicate an average delivery rate in each direction of approximately 7/8 the modem (modulation system) bit rate with a mean time to error of several hundred years. The philosophy which guided the design of this system can be applied to other media, where high noise bursts or low signal levels occur infrequently.
A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells (2014)

While human pluripotent stem cells are attractive sources for cell-replacement therapies, a major concern remains regarding their tumorigenic potential. Thus, safety assessment of human pluripotent stem cell-based products in terms of tumorigenicity is critical. Previously we have identified a pluripotent stem cell-specific lectin probe rBC2LCN recognizing hyperglycosylated podocalyxin as a cell surface ligand. Here we demonstrate that hyperglycosylated podocalyxin is secreted from human pluripotent stem cells into cell culture supernatants. We establish a sandwich assay system, named the GlycoStem test, targeting the soluble hyperglycosylated podocalyxin using rBC2LCN. The GlycoStem test is sufficiently sensitive and quantitative to detect residual human pluripotent stem cells. This work provides a proof of concept for the noninvasive and quantitative detection of tumorigenic human pluripotent stem cells using cell culture supernatants. The developed method should increase the safety of human pluripotent stem cell-based cell therapies.
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer (2018)

Abstract Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the hormone-DNA repair circuit to enable molecularly-specific alpha particle irradiation of PCa. Alpha-particle irradiation of PCa is prompted by molecularly specific-targeting and internalization of the humanized monoclonal antibody hu11B6 targeting hK2 and further accelerated by inherent DNA-repair that up-regulate hK2 (KLK2) expression in vivo. hu11B6 demonstrates exquisite targeting specificity for KLK2. A single administration of actinium-225 labeled hu11B6 eradicates disease and significantly prolongs survival in animal models. DNA damage arising from alpha particle irradiation induces AR and subsequently KLK2, generating a unique feed-forward mechanism, which increases binding of hu11B6. Imaging data in nonhuman primates support the possibility of utilizing hu11B6 in man.
Identification of a fourth family of lycopene cyclases in photosynthetic bacteria (2007)

A fourth and large family of lycopene cyclases was identified in photosynthetic prokaryotes. The first member of this family, encoded by the cruA gene of the green sulfur bacterium Chlorobium tepidum, was identified in a complementation assay with a lycopene-producing strain of Escherichia coli. Orthologs of cruA are found in all available green sulfur bacterial genomes and in all cyanobacterial genomes that lack genes encoding CrtL- or CrtY-type lycopene cyclases. The cyanobacterium Synechococcus sp. PCC 7002 has two homologs of CruA, denoted CruA and CruP, and both were shown to have lycopene cyclase activity. Although all characterized lycopene cyclases in plants are CrtL-type proteins, genes orthologous to cruP also occur in plant genomes. The CruA- and CruP-type carotenoid cyclases are members of the FixC dehydrogenase superfamily and are distantly related to CrtL- and CrtY-type lycopene cyclases. Identification of these cyclases fills a major gap in the carotenoid biosynthetic pathways of green sulfur bacteria and cyanobacteria.
Photodynamic therapy of epithelial skin tumours using delta-aminolaevulinic acid and desferrioxamine (1995)

Photodynamic therapy (PDT) uses photosensitizing drugs, such as porphyrins, and light for cancer treatment. In the present clinical study we employed topical application of the porphyrin precursor delta-aminolaevulinic acid (ALA) in combination with desferrioxamine (df) for the induction of endogenous porphyrin synthesis. Irradiation was performed with a light source consisting of a halogen lamp with a red filter and a fibreoptic device. Irradiances ranged from 50 to 300 mW/cm2. We treated 49 patients with this PDT regimen. In 32 patients we treated a total of 34 superficial basal cell carcinomas (BCCs) and 22 nodular BCCs, in nine patients 43 solar keratoses, and in eight patients 10 lesions of Bowen's disease. After a single treatment, 30 (88.2%) of the superficial and seven (31.8%) of the nodular BCCs, 35 of 43 (81.4%) solar keratoses, and three (30%) of the Bowen's disease lesions showed complete remission. The post-treatment observation period was up to 20 months. Repeat therapy was required in six nodular and four superficial BCCs. Biopsies were obtained before treatment, and at variable intervals after treatment. Topical PDT of skin tumours with ALA-df-induced porphyrins is effective in the management of epithelial skin tumours.
Role for the Rac1 Exchange Factor Vav in the Signaling Pathways Leading to NK Cell Cytotoxicity (1999)

Here we investigate the activation of and a possible role for the hematopoietic Rac1 exchange factor, Vav, in the signaling mechanisms leading to NK cell-mediated cytotoxicity. Our data show that direct contact of NK cells with a panel of sensitive tumor targets leads to a rapid and transient tyrosine phosphorylation of Vav and to its association with tyrosine-phosphorylated Syk. Vav tyrosine phosphorylation is also observed following the activation of NK cells through the low-affinity Fc receptor for IgG (Fc gamma RIII). In addition, we demonstrate that both direct and Ab-mediated NK cell binding to target cells result in the activation of nucleotide exchange on endogenous Rac1. Furthermore, Vav antisense oligodeoxynucleotide treatment leads to an impairment of NK cytotoxicity, with Fc gamma RIII-mediated killing being more sensitive to the abrogation of Vav expression. These results provide new insight into the signaling pathways leading to cytotoxic effector function and define a role for Vav in the activation of NK cell-mediated killing.
Feature-adaptive GPU rendering of Catmull-Clark subdivision surfaces (2012)

We present a novel method for high-performance GPU-based rendering of Catmull-Clark subdivision surfaces. Unlike previous methods, our algorithm computes the true limit surface up to machine precision, and is capable of rendering surfaces that conform to the full RenderMan specification for Catmull-Clark surfaces. Specifically, our algorithm can accommodate base meshes consisting of arbitrary valence vertices and faces, and the surface can contain any number and arrangement of semisharp creases and hierarchically defined detail. We also present a variant of the algorithm which guarantees watertight positions and normals, meaning that even displaced surfaces can be rendered in a crack-free manner. Finally, we describe a view-dependent level-of-detail scheme which adapts to both the depth of subdivision and the patch tessellation density. Though considerably more general, the performance of our algorithm is comparable to the best approximating method, and is considerably faster than Stam's exact method.
Prevention of urotoxic side effects by regional detoxification with increased selectivity of oxazaphosphorine cytostatics. (1986)

Urotoxic side effects, particularly haemorrhagic cystitis, have been a limiting factor for the therapeutic use of the oxazaphosphorine cytostatics cyclophosphamide, ifosfamide and trofosfamide. The development of mesna (Uromitexan) has made it possible to carry out regional detoxification in the kidneys and the efferent urinary tract and thus to achieve clinically prophylaxis against the urotoxic side effects of oxazaphosphorines. In the body, mesna is rapidly converted to the biologically inactive disulfide form (dimesna). After glomerular filtration, dimesna is reduced by interaction with the glutathione system of the renal tubular cells and is excreted in the urine as mesna, the free thiol compound. This compound is then capable of definitively detoxifying the oxazaphosphorine metabolites in the urine. In extensive experiments on rats, it has been demonstrated that the cyclophosphamide-induced occurrence of urinary bladder tumours could be reduced or even eliminated by simultaneous administration of mesna. Detoxification by mesna enables the clinical use of higher doses and, consequently, a possible increase in therapeutic efficiency.
ChemInform Abstract: ON THE ACTIVE SPECIES OF ALUMINUM(III) BROMIDE‐COPPER(II) SULFATE MIXTURES AS CATALYSTS FOR THE ISOMERIZATION OF PENTANE (1980)

Abstract Mischungen von AlBr 3 und CuSO 4 besitzen eine hohe katalytische Aktivität und Selektivität für die Isomerisierung von Pentan bei Raumtemperatur.
Interaction between complementary liposomes: a process leading to multicompartment systems formation (2005)

Interaction of complementary liposomes induces a series of processes, involving reorganization of their membrane lipids, which lead to the formation of large aggregates. In several cases these aggregates exhibit multicompartment structures and only primitively mimic, in some aspects at least, the multicompartmental features of cells. Similar multicompartment structures were repeatedly obtained following the interaction of a diversity of complementary liposomal pairs. Thus, a working hypothesis is proposed, according to which, molecular recognition of liposomes induces the formation of multicompartment structures.
Electronic Publishing and College Journal (2000)

College journal is an important Component of college academic periodical.The traditional college journal cannot apply to the time of knowledge economy. Electronic publication stands for the trend of college journal development in the future.
Application of a Quartz Crystal Microbalance to the Study of Copper Corrosion in Acid Solution Inhibited by Triazole‐Iodide Protective Films (1995)

When one uses one side of a quartz crystal microbalance as the working electrode in electrochemical experiments, mass changes can be monitored continuously with a sensitivity of a few nanograms per square centimeter. In this study the working electrode consisted of electrolytically deposited copper, exposed to 0.1M sodium sulfate at pH 3, open to the atmosphere and in some cases containing . Upon addition of one of the inhibitors, benzotriazole (BTA), tolyltriazole (TTA), carboxy‐benzotriazole (CBT), or these inhibitors plus potassium iodide, the rate of frequency change decreases markedly. After removal of the inhibitors from the corrosive medium by fast solution exchange there is a marked continuing protective effect of the inhibitor films in the cases of BTA + KI and TTA + KI with the latter being the most stable and protective of all of the films. The results were qualitatively the same in the more corrosive solution containing .
Corrosion Control in the Geothermal Drilling Industry (1986)

Abstract Geothermal drill pipe corrosion can cause excessive metal loss, leading to costly failures. It has been increasingly realized in the drilling industry that implementation of a successful corrosion control program is essential to reduce drilling costs and maintain an efficient drilling operation. An attempt is made in this paper to describe the corrosion problems encountered and how to protect the drill pipe metal surface. This is achieved by discussion of the effects of high temperature, pressure and corrosive reactions. Corrosion mitigation techniques, in terms of cost-effective chemical treatments, are described. Emphasis is placed on the practical aspects of applying these treatments based upon experience of the last few years in the Asia Pacific area. The specifics of an individual treatment depend upon the nature of the drilling fluid, downhole conditions and the actual or anticipated corrosion problem. Guidelines are given for implementing a successful corrosion control program, and an idealized monitoring system is described. Case history information is included stressing how corrosion control, which the operator sees as a "no payout" maintenance item, will ultimately reduce drilling costs and increase efficiency.
Synthesis of metallothionein-like peptides cadystin A and B occurring in a fission yeast, and their isomers. (1985)

The unit peptides, cadystin A and B, in the cadmium-containing peptides occurring in a fission yeast were synthesized for confirmation of the structure. Four possible stereoisomers of the previously proposed structure for cadystin were also synthesized.
THE ALKYLATION OF HYDROXYNAPHTHOQUINONE I. ORTHO-ETHERS (1926)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE ALKYLATION OF HYDROXYNAPHTHOQUINONE I. ORTHO-ETHERSLouis F. FieserCite this: J. Am. Chem. Soc. 1926, 48, 11, 2922–2937Publication Date (Print):November 1, 1926Publication History Published online1 May 2002Published inissue 1 November 1926https://pubs.acs.org/doi/10.1021/ja01690a026https://doi.org/10.1021/ja01690a026research-articleACS PublicationsRequest reuse permissionsArticle Views248Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Introduction (2016)

Abstract Before the crisis European countries were engaged in structural reforms to boost long-run growth, and institutional changes to deepen European integration. Will the crisis cause an acceleration of these processes, or will it complicate them? In the short term, some of the hardest hit countries in the periphery were forced to adopt several new structural reforms; however, these reforms were often largely perceived as externally imposed. Furthermore, they were often presented to the public as remedies against the cyclical downturn. The lack of domestic ownership, the misrepresentation of the benefits of reform, and the association with policies that deepened the crisis may erode public support for further reform. In addition, the crisis is perceived by many as having being exacerbated by EMU and EU membership. This may have eroded support for further European integration, and may imply that structural reform and European integration are no longer complementary.
Similar Efficacy of Abrupt and Gradual Opiate Detoxification (1991)

A study comparing abrupt and gradual opiate detoxification which identified the efficacy by means of computer-assisted pupilometry and rating of withdrawal distress is presented. This paper concentrates on the efficacies of these two detoxification modes with regard to the identical results after successful opiate detoxification treatment. The findings of the present investigation support the hypothesis that withdrawal distress returns to a normal level after rapid naloxone withdrawal treatment within 6 days. Similar results can be seen for inpatient methadone withdrawal after 3 weeks of treatment. These results indicate that by rapid detoxification therapy, the time of withdrawal can be effectively shortened. Considering the low dropout rate and the high degree of acceptance during rapid detoxification, the rapid detoxification regimen is an effective and economic alternative to gradual withdrawal treatments.