gebhart/patrepeval huggingface dataset:
Targeting FLT3 for the Treatment of Leukemia (2008)

FLT3 is a receptor tyrosine kinase with important roles in hematopoietic stem/progenitor cell survival and proliferation. It is frequently overexpressed in acute leukemias and is frequently mutated in acute myeloid leukemia (AML). FLT3 internal tandem duplication (ITD) mutations in AML portend poor prognosis in both adult and pediatric patients. A number of small molecule tyrosine kinase inhibitors (TKIs) with activity against FLT3 have been discovered. Many of these are still in preclinical development, but several have entered clinical phase I and II trials as monotherapy in patients with relapsed AML. These trials have resulted in frequent but short-lived responses of peripheral blasts and less frequent responses of bone marrow blasts. This led to clinical testing of FLT3 TKIs in combination with conventional chemotherapy. Several combination trials are ongoing or planned in both relapsed and newly diagnosed FLT3-mutant AML patients. Anti-FLT3 antibodies may also prove to be an excellent way of targeting FLT3 in AML and acute lymphocytic leukemia (ALL) by inhibiting signaling and through antibody-dependent cell-mediated cytotoxicity.
Production of Nuclear Transfer Horse Embryos by Piezo-Driven Injection of Somatic Cell Nuclei and Activation with Stallion Sperm Cytosolic Extract1 (2002)

We investigated the use of direct nuclear injection using the Piezo drill and activation by injection of stallion sperm cytosolic extract for production of cloned equine embryos. When metaphase II horse oocytes were injected with either of two dosages of sperm extract and cultured 20 h, similar activation rates (88% vs. 90%) and cleavage rates (49% vs. 46%) were obtained. The successful reconstruction rate of horse oocytes with horse somatic cell donor nuclei after direct injection using the Piezo drill was 82%. Four dosages of sperm extract (containing 59, 176, 293, or 1375 microg/ml protein) and two activation times (1.5-2 vs. 8-10 h after nuclear transfer) were examined. Cleavage and activation (pseudopronucleus formation) rates of oocytes injected with sperm extract containing 59 microg/ml protein were significantly (P < 0.05) lower than any other dosage. The percentage of embryos cleaving with normal nuclei in oocytes injected with the 1375 microg/ml preparation 1.5-2 h after donor injection was significantly (P < 0.05) higher than that of the 293 microg/ml preparation 8-10 h after donor injection (22 vs. 6%). Embryos developed to a maximum of 10 nuclei. Interspecies nuclear transfer was performed by direct injection of horse nuclei into enucleated bovine oocytes, followed by chemical activation. This resulted in 81% reconstruction (successful injection of the donor cell), 88% cleavage, and 73% cleavage with normal nuclei. These results indicate that direct nuclear injection using the Piezo drill is an efficient method for nuclear transfer in horse and cattle oocytes and that sperm extract can efficiently activate horse oocytes both parthenogenetically and after nuclear transfer
On the molecular interaction between femoral heads and polyethylene liners in artificial hip joints: phenomenology and molecular scale phenomena (2016)

The chemical interaction of femoral heads with polyethylene liners is an important new area of research in total hip arthroplasty (THA) as a consequence of an unabating quest for elongated artificial joint lifetimes. It is a topic that goes beyond simple mechanical behavior or wear. It seeks to describe the prosthetic device as a whole by adding chemical considerations to mechanics and abrasion. One of the poorly understood chemical interactions is oxygen affinity of the femoral heads. While oxygen unavoidably diffuses into the non-crystalline enclaves of the polyethylene liner as a result of its contact with the tribolayer, a ceramic femoral head can either attract or release oxygen due to its tribochemical interactions. In this study, changes in liner crystallinity and oxidation were observed during simple static contact with different femoral heads within a hydrothermal environment. Examinations were made using Raman microprobe spectroscopy coupled with nanometer-scale spectroscopic analyses (x-ray photoelectron spectroscopy (XPS) and cathodoluminescence (CL) spectroscopy) on different sets of ceramic and polyethylene couples exposed for increasing periods to a hydrothermal environment. Even in the absence of frictional loading, structural modifications were clearly detected, statistically validated, and correlated with the oxygen affinity of various femoral head materials. It was found that oxide (Al<sub>2</sub>O<sub>3</sub>, Al<sub>2</sub>O<sub>3</sub>/ZrO<sub>2</sub>, and m-ZrO<sub>2</sub>) and non-oxide (Si<sub>3</sub>N<sub>4</sub>) ceramic heads release or attract nascent oxygen species, respectively. This research unequivocally identified a new gap in our knowledge of THA biomaterial interactions, with future studies and material improvements undoubtedly leading to an increase in longevity for prosthetic joints.
A simple method for calculating the proportions of various substances of known composition to give a mixture of definite composition (1932)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTA simple method for calculating the proportions of various substances of known composition to give a mixture of definite compositionH. V. Houseman Cite this: J. Chem. Educ. 1932, 9, 5, 941Publication Date (Print):May 1, 1932Publication History Received3 August 2009Published online1 May 1932Published inissue 1 May 1932https://doi.org/10.1021/ed009p941.2RIGHTS & PERMISSIONSArticle Views177Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Metastatic breast carcinoma of the orbit (1989)

Two Caucasian females in whom an orbital mass was the first sign of metastasis from a breast carcinoma are described. Each subject had undergone a radical mastectomy to treat a primary breast carcinoma, one six years and the other eight years previously. Each presented with ipsilateral proptosis, and restricted upper eyelid action; one had altered ocular motility. In each subject an open biopsy of the orbital mass via an eyelid crease incision revealed metastatic scirrhous adenocarcinoma of the breast. The clinical features, investigations, and treatment of orbital metastases from breast carcinoma are discussed.
Hirudin and sulotroban improve coronary blood flow after reperfusion induced by the novel recombinant plasminogen activator BM 06.022 in a canine model of coronary artery thrombosis. (1992)

Thrombus formation in anesthetized, open-chest dogs was induced by electrical injury to the intimal surface of the left circumflex coronary artery. One-hour postocclusion, administration of vehicle to heparinized dogs (n = 12) did not induce reperfusion despite concomitant treatment with acetylsalicylic acid (ASA), sulotroban, or saline. Intravenous bolus injection of 140 kU/kg (= 0.24 mg/kg) of the unglycosylated t-PA variant BM 06.022 induced reperfusion in 4 out of 6 dogs, followed by flow deterioration. Pretreatment with i.v. ASA did not improve coronary blood flow (CBF). Conjunctive treatment with the thromboxane A2-receptor antagonist, sulotroban, (10 mg/kg i.v. bolus, followed by 10 mg/kg/h) or with recombinant hirudin, a specific thrombin inhibitor, (1 mg/kg/h) 30 min prior to i.v. injection of BM 06.022, prolonged (p < 0.01) the cumulative patency time (sum of time-intervals in which the coronary artery was patent) to 147.4 +/- 9.2 min in 4 out of 6 reperfused dogs and 129.9 +/- 12.3 min in 7 out of 8 dogs, respectively, compared to the saline plus BM 06.022 treatment (47.5 +/- 13.1 min) in 4 out of 6 dogs. The terminal CBF was higher (p < 0.01) after sulotroban plus BM 06.022 (7.0 +/- 1.7 ml/min) and hirudin plus BM 06.022 (6.3 +/- 1.5 ml/min) than after saline plus BM 06.022 (0.8 ml/min). These findings demonstrate that drugs with antithromboxane or antithrombin activity may improve CBF after reperfusion.
New lightweight materials: Balsa wood‐polymer composites based on ethyl α‐(hydroxymethyl)acrylate (1993)

Abstract It is clearly demonstrated here that ethyl α‐(hydroxymethyl)acrylate (EHMA) is a unique monomer for increasing the dimensional stability and physical properties of balsa wood. Copolymers containing EHMA, and especially EHMA‐styrene mixtures, were shown to improve the dimensional stability (water soak test) and the absolute mechanical properties of balsa wood. Improvements in specific modulus and specific toughness (absolute properties divided by specific gravity) were achieved using an EHMA‐styrene monomer mixture with polybutadiene diacrylate as cross‐linker and toughening agent, with the best results obtained at low (10–40%) weight gain. This is the first report that we are aware of describing specific property improvement greater than expected based on density increase. These improvements in modulus and toughness were ascribed to efficient penetration of monomers into the cell walls. Solid‐state NMR and scanning electron microscopy confirmed strong interaction of the copolymers generated in situ with wood cell wall components, consistent with the property improvements obtained. The combination of a light‐weight, renewable wood precursor with synergistic reinforcement by this combination of monomers offers unique opportunities for increased use of wood‐polymer composites in a wide variety of structural and insulating applications. © 1993 John Wiley & Sons, Inc.
Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation (2017)

Reactive oxygen species (ROS) are believed to play a major role in the proinflammatory, M1-polarized form of neuroinflammation. However, it has been difficult to assess the role of ROS and their role in neuroinflammation in animal models of disease because of the absence of probes capable of measuring their presence with the functional imaging technique positron emission tomography (PET). This study describes the synthesis and in vivo evaluation of [<sup>18</sup>F]ROStrace, a radiotracer for imaging superoxide in vivo with PET, in an LPS model of neuroinflammation. [<sup>18</sup>F]ROStrace was found to rapidly cross the blood-brain barrier (BBB) and was trapped in the brain of LPS-treated animals but not the control group. [<sup>18</sup>F] ox-ROStrace, the oxidized form of [<sup>18</sup>F]ROStrace, did not cross the BBB. These data suggest that [<sup>18</sup>F]ROStrace is a suitable radiotracer for imaging superoxide levels in the central nervous system with PET.
Gigahertz-band analogue switch using bipolar super self-aligned process technology (1985)

A novel bipolar analogue switch has been developed using super self-aligned process technology (SST). The switch with three emitter-coupled pairs achieved high net isolation of 40 dB and low third-order intermodulation of less than −40 dB below the input level of −7 dBm at 1 GHz.
Methanethiol metabolism in whole blood. (1988)

The metabolism of methanethiol in whole blood has been described. Incubation of carbon 14-labeled or sulfur 35-labeled gaseous methanethiol resulted in complete trapping of methanethiol by whole blood within 30 minutes. After trapping, both labels were found to be equally distributed over plasma and erythrocytes. Eighty to ninety percent of both labels could be extracted from erythrocytes incubated in saline solution. The chemical properties of the 14C and 35S labels in saline solution differed completely. The 14C label was not precipitated by BaCl2, was moderately volatile, and could be extracted by either (pH 1). In contrast, the 35S label was precipitated by BaCl2, was not volatile, and was not extracted by ether. It is concluded that the central carbon-sulfur bond of methanethiol is split by incubation with whole blood. Plasma components are not involved in this process. Most likely, methanethiol becomes largely oxidized by erythrocytes to formic acid and sulfite or sulfate. Only 10% of methanethiol became firmly bound to erythrocytes. One to two percent was transformed to protein--S--S--CH3 and 1% to dimethyl sulfide by the enzyme thiol methyltransferase.
El largo camino hacia la especialización: cursos y masters proliferan ante las exigencias del mercado. (1991)

Segun datos estadisticos de la Facultad de Ciencias de la Informacion, este ano 11.889 alumnos han solicitado la carrera de Publicidad, lo que en terminos globales representa el 22,23 por 100 del total del alumnado de la Universidad Complutense. Los nuevos licenciados en Publicidad se enfrentan con un presente nada claro y un mercado de trabajo menos determinado todavia. Un plan se estudios que carece de enfoque practico y la recesion economica mundial afectan de forma negativa al sector publicitario, que se ve forzado a cambiar sus tecnicas creativas y comerciales, para continuar siendo rentable y competitivo.
High-Throughput Multiple Dies-to-Wafer Bonding Technology and III/V-on-Si Hybrid Lasers for Heterogeneous Integration of Optoelectronic Integrated Circuits (2015)

Integrated optical light source on silicon is one of the key building blocks for optical interconnect technology. Great research efforts have been devoting worldwide to explore various approaches to integrate optical light source onto the silicon substrate. The achievements so far include the successful demonstration of III/V-on-Si hybrid lasers through III/V-gain material to silicon wafer bonding technology. However, for potential large-scale integration, leveraging on mature silicon complementary metal oxide semiconductor (CMOS) fabrication technology and infrastructure, more effective bonding scheme with high bonding yield is in great demand considering manufacturing needs. In this paper, we propose and demonstrate a high-throughput multiple dies-to-wafer (D2W) bonding technology which is then applied for the demonstration of hybrid silicon lasers. By temporarily bonding III/V dies to a handle silicon wafer for simultaneous batch processing, it is expected to bond unlimited III/V dies to silicon device wafer with high yield. As proof-of-concept, more than 100 III/V dies bonding to 200 mm silicon wafer is demonstrated. The high performance of the bonding interface is examined with various characterization techniques. Repeatable demonstrations of 16-III/V-die bonding to pre-patterned 200 mm silicon wafers have been performed for various hybrid silicon lasers, in which device library including Fabry-Perot (FP) laser, lateral-coupled distributed feedback (LC-DFB) laser with side wall grating, and mode-locked laser (MLL). From these results, the presented multiple D2W bonding technology can be a key enabler towards the large-scale heterogeneous integration of optoelectronic integrated circuits (H-OEIC).
Treatment Conditions and Biochemical Processes Influencing Seed Priming Effectiveness (2012)

A review of the scientific literature indicates osmotic priming (osmopriming) as the principal method of seed priming and polyethylene glycol (PEG) as the principal osmotic agent. An analysis of the available data across experiments carried out with different species under varying conditions showed an average 11% increase in percent germination and 36% shorter mean germination time (MGT) in primed vs. unprimed seeds. Moreover, in primed seeds MGT was less dependent on temperature, which is consistent with the effects expected from the treatment. Priming effects are mainly influenced by osmotic potential, temperature and time; major biochemical processes (repair of damaged DNA and RNA, preparation for cell division and increased antioxidant activity) are involved in treatment effects to an extent which is not fully ascertained in literature. A reduction of seed storage life is the major disadvantage of priming and the principal constraint to its diffusion, since dehydration to the initial moisture (drying-back) is needed to allow seed storage. Seed behaviour during drying-back, the role of the raffinose family oligosaccharides in cell membrane integrity and the expression of antioxidant enzymes in germinating seeds need to be further elucidated in a sufficient number of species, to promote a more reliable use of this technique.
Attributable Morbidity and Mortality of Catheter-Related Septicemia in Critically Ill Patients: a Matched, Risk-Adjusted, Cohort Study (1999)

CRS is associated with subsequent morbidity and mortality in the ICU, even when adjusted on severity factors at ICU admission. However, after adjustment on severity factors during the ICU stay and before the event, there was only a trend toward CRS-attributable mortality. The evolution of patient severity should be taken into account when evaluating excess mortality induced by nosocomial events in ICU patients.
Purification, immunolocalization, cryoprotective, and antifreeze activity of PCA60: A dehydrin from peach (<i>Prunus persica</i>) (1999)

Dehydrins are glycine‐rich, hydrophilic, heat‐stable proteins and are generally induced in response to a wide array of environmental stresses. In previous research (Artlip et al. 1997, Plant Molecular Biology 33: 61–70), a full‐length dehydrin gene, ppdhn1 , was isolated from peach, and its expression was associated with qualitative and quantitative differences in cold hardiness in sibling genotypes of evergreen and deciduous peach. Similar results were obtained for levels of the corresponding 60 kDa peach dehydrin protein (PCA60). The objective of the present study was to purify the PCA60, test the purified protein for cryoprotective and/or antifreeze activity, and to determine the cellular localization of PCA60 using immunomicroscopy. PCA60 was extracted from winter bark tissues of peach ( Prunus persica [L.] Batsch) and purified in a two‐step process. Separation was based on free‐solution isoelectric focusing followed by size exclusion. Purified PCA60, as well as crude protein extract, preserved the in vitro enzymatic activity of lactate dehydrogenase after several freeze‐thaw cycles in liquid nitrogen. PCA also exhibited distinct antifreeze activity as evidenced by ice crystal morphology and thermal hysteresis. This is the first time antifreeze activity has been demonstrated for dehydrins. Immunomicroscopy, utilizing an affinity‐purified, polyclonal antibody developed against a synthetic peptide of the lysine‐rich consensus portion of dehydrins, indicated that PCA60 was freely distributed in the cytoplasm, plastids, and nucleus of bark cells and xylem parenchyma cells. Although the functional role of dehydrins remains speculative, the data support the hypothesis that it plays a role in preventing denaturation of proteins exposed to dehydrative stresses.
Biliary stones and sludge in liver transplant patients: a 13-year experience. (1996)

Stones and sludge are relatively infrequent after liver transplantation but are associated with high morbidity. Surgical or interventional radiologic treatments are usually performed. Bile duct stones are usually treated with surgical biliary reconstruction. While debris and bile duct necrosis are due to ischemia from hepatic artery occlusion, sludge may also have an ischemic pathogenesis in some cases.
Video object segmentation introducing depth and motion information (2002)

We present a method to estimate the relative depth between objects in scenes of video sequences. The information for the estimation of the relative depth is obtained from the overlapping produced between objects when there is relative motion as well as from motion coherence between neighbouring regions. A relaxation labelling algorithm is used to solve conflicts and assign every region to a depth level. The depth estimation is used in a segmentation scheme which uses grey level information to produce a first segmentation. Regions of this partition are merged on the basis of their depth level.
An interactive debugging facility for GPSS (1977)

This paper describes the interactive debugging feature of GPSS/H (1), a new implementation of GPSS for IBM 360/370 computers. In GPSS/H, interactive debugging of a simulation model is carried out by means of a simple, but powerful command language. Commands are provided to selectively display model data on a terminal, to set breakpoints at arbitrary points in a model, and to step through a model one or more blocks at a time. An overview of the command language and an illustrative example of its use are presented in this paper.
Atomic layer deposition of Al-incorporated Zn(O,S) thin films with tunable electrical properties (2014)

Zinc oxysulfide, Zn(O,S), films grown by atomic layer deposition were incorporated with aluminum to adjust the carrier concentration. The electron carrier concentration increased up to one order of magnitude from 1019 to 1020 cm−3 with aluminum incorporation and sulfur content in the range of 0 ≤ S/(Zn+Al) ≤ 0.16. However, the carrier concentration decreased by five orders of magnitude from 1019 to 1014 cm−3 for S/(Zn+Al) = 0.34 and decreased even further when S/(Zn+Al) &gt; 0.34. Such tunable electrical properties are potentially useful for graded buffer layers in thin-film photovoltaic applications.
Bug damage in New Zealand wheat grain: The role of various heteropterous insects (1992)

Abstract Certain heteropterousinsects (true bugs) in New Zealand deposit salivary enzymes into immature wheat grain while feeding. These enzymes survive in harvested wheat, destroy gluten structure in dough, and cause poor quality bread. This study investigates what insect is responsible for bug‐damaged wheat The following field‐collected insect species were caged on wheat at the watery ripe growth stage: Nysius huttoni, Rhypodes sp., Stenotus binotatus, Calocoris norvegicus, Sidnia kinbergi , and Dictyotus caenosus . All the insects produced visible signs of damage on kernels and reduced kernel weight, but only wheat damaged by N. huttoni and S. binotatus had sufficiently high levels of pH 9 active, gluten‐degrading enzyme to cause poor quality bread. However, the electrophoretic patterns of protein subunits from degraded glutenand the characteristics of bug damage in bread were different for these two insects. Also, the appearances of the damaged kernels and levels of α‐amylase were clearly different in the two samples. Only wheat damaged by N. huttoni showed all the characteristics of naturally bug‐damaged wheat harvested and tested in New Zealand during the last decade.