gebhart/patrepeval huggingface dataset:
Study on management system of CNC milling parameters (2012)

In view of complexity of CNC milling process,the paper took horizontal machining center DMC60H as the study platform and collected the machining data of shell aluminum alloy hydraulic parts in the aircraft engine.In addition,it built the management system of CNC milling parameters suitable for the machinery manufacturing enterprises,so as to realized rapid and reasonable selection of CNC milling parameters.Application results showed that the management system could realize efficient management of CNC milling information,so as to improve the employment efficiency of CNC milling information.The system has certain promotion for the development of CNC milling manufacturing and production enterprises.
Metallic implant geometry and susceptibility estimation using multispectral B<sub>0</sub>field maps (2016)

The proposed method can improve the delineation of metallic implant geometry by distinguishing metal voxels from artificial signal voids and low-signal tissues by estimating the susceptibility maps. Magn Reson Med 77:2402-2413, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology (2011)

These guidelines from the British Association for Psychopharmacology address the scope and targets of pharmacological treatment for schizophrenia. A consensus meeting, involving experts in schizophrenia and its treatment, reviewed key areas and considered the strength of evidence and clinical implications. The guidelines were drawn up after extensive feedback from the participants and interested parties, and cover the pharmacological management and treatment of schizophrenia across the various stages of the illness, including first-episode, relapse prevention, and illness that has proved refractory to standard treatment. The practice recommendations presented are based on the available evidence to date, and seek to clarify which interventions are of proven benefit. It is hoped that the recommendations will help to inform clinical decision making for practitioners, and perhaps also serve as a source of information for patients and carers. They are accompanied by a more detailed qualitative review of the available evidence. The strength of supporting evidence for each recommendation is rated.
Study on the Burning Rate of a Char Particle under Forced Convection Conditions (1998)

According to the special feature of the flow outside a char particle under forced convection conditions (Re < 150), a simplified model for calculating the burning rate of a char particle is presented in this paper. The burning processes of frontal and rear hemispheres are discussed, respectively. The effects of both flow and ash formation are considered in the study. Based on this model, a numerical simulation of the burning process is conducted for different type of char. Good agreement of the calculated results with corresponding experiment data demonstrates that this model is reasonable for the case with Re ≤ 150.
Derivational analogy and its role in problem solving (1983)

Measurement of the angular and overlap dependence of the conduction between two identical carbon nanotubes (CNTs), with the same diameter and chirality, has only been possible through theoretical calculations; however, our observation of increased resistance adjacent to the junction between two CNTs facilitates such measurements. Since electrical resistance was found to increase with increased diameter ratio, applying 10 V to one of dissimilar diameter CNTs results in cleavage at the junction. Manipulation of the resulting identical CNTs (created by cutting a single CNT) allows for the direct measurement of the angular and parallel overlap conduction. Angular (13° < θ < 63°) dependence shows two minima (22° and 44°) and a maximum at 30°, and conduction between parallel CNTs increases with overall tip separation but shows a sinusoidal relationship with contact length, consistent with the concept of atomic scale registry.
Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells (2001)

The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) proteins play a central role in the early steps of signal transduction by TNFR superfamily proteins, which induce various cellular responses, including apoptosis. Influences of TRAF proteins on the regulation of cell death and physical interactions between TRAFs and caspases have been reported. In this study, we demonstrate that TRAF3 is proteolyzed during cell death in a caspase-dependent manner. TRAF3 was found to be cleaved by incubation with caspase3 in vitro and by Fas- or CD3-triggering in Jurkat-T cells. The Fas- or CD3-induced cleavage of TRAF3 was blocked by caspase inhibitors and by introduction of alanine substitutions for D347 and D367 residues. Furthermore, the amino-terminal fragment of TRAF3 showed a different intracellular localization from the full-length TRAF3 with preferential distribution to particulate fractions and the nucleus. These findings suggest that TRAF3 may be regulated by caspases during apoptosis of T cells.
Phase I trial of Wilms' Tumor 1 (WT1) peptide vaccine with GM-CSF or CpG in patients with solid malignancy. (2012)

Addition of GM-CSF or CpG-ODN to the WT1 peptide vaccine for patients with solid malignancy was safe and improved the effectiveness of clinical response.
Patient record access--the time has come. (2006)

There are now a number of systems across the world that enables patients to view their electronic health records. These include kiosks that have fingerprint authentication and also net-based access. The paper outlines the approach taken by the UK NHS explains the legal underpinning of access. Starting form the premise that record access is here to stay the paper outlines the research on benefits and risks of record access, concluding that, with simple precautions, record access is safe and affords many benefits to both patients and clinicians. It goes on to consider possible impacts of record access on the way records might be written as a co-produced document and emphasizes that national standards for record sharing need to be written.
A new robotic approach to characterize mechanical impedance and energetic passivity of the human ankle during standing (2017)

This paper presents the quantitative characterization of ankle impedance and ankle passivity during upright standing. A novel multi-axis robotic platform allows for the quantification of these neuromuscular properties in two degrees-of-freedom of the ankle, specifically, dorsiflexion-plantarflexion (DP) and inversion-eversion (IE). For the slow sinusoid perturbations of low frequencies ranging up to 1.5 Hz, ankle impedance was accurately approximated by stiffness and damping, while the contribution of inertia and reflex feedback was minimal. Ankle stiffness and damping were found to be highly direction dependent, being much higher in the DP than IE direction. Ankle stiffness linearly increased with co-contraction of ankle muscles. While the same trend was evident for ankle damping in the DP direction, no significant changes were observed in the IE direction. In addition, the ankle behavior was found to be highly dissipative in both DOFs over a wide range of muscle activation for young healthy subjects. Characterization results in this study would not only provide an insight into the functional contribution of the ankle to the control of postural balance but also add valuable information in the development of neuro-rehabilitation and assistive devices.
Histamine-H1-receptor-mediated phosphoinositide hydrolysis, Ca2+ signalling and membrane-potential oscillations in human HeLa carcinoma cells (1990)

In human HeLa carcinoma cells, histamine causes a dose-dependent formation of inositol phosphates, production of diacylglycerol and a transient rise in intracellular [Ca2+]. These responses are completely blocked by the H1-receptor antagonist pyrilamine. In streptolysin-O-permeabilized cells, formation of inositol phosphates by histamine is strongly potentiated by guanosine 5'-[gamma-thio]triphosphate and inhibited by guanosine 5'-[beta-thio]diphosphate, suggesting the involvement of a GTP-binding protein. Histamine stimulates the rapid but transient formation of Ins(1,4,5)P3, Ins(1,3,4)P3 and InsP4. InsP accumulates in a much more persistent manner, lasting for at least 30 min. Studies with streptolysin-O-permeabilized cells indicate that InsP accumulation results from dephosphorylation of Ins(1,4,5)P3, rather than direct hydrolysis of PtdIns. The rise in intracellular [Ca2+] is biphasic, with a very fast release of Ca2+ from intracellular stores, that parallels the Ins(1,4,5)P3 time course, followed by a more prolonged phase of Ca2+ influx. In individual cells, histamine causes a rapid initial hyperpolarization of the plasma membrane, which can be mimicked by microinjected Ins(1,4,5)P3. Histamine-induced hyperpolarization is followed by long-lasting oscillations in membrane potential, apparently owing to periodic activation of Ca2+-dependent K+ channels. These membrane-potential oscillations can be mimicked by microinjection of guanosine 5'-[gamma-thio]triphosphate, but are not observed after microinjection of Ins(1,4,5)P3. We conclude that H1-receptors in HeLa cells activate a PtdInsP2-specific phospholipase C through participation of a specific G-protein, resulting in long-lasting oscillations of cytoplasmic free Ca2+.
Investigation of the thoracic electrical impedance during endotoxemia in dogs. (1997)

The purpose of our study was to examine the effect of sustained low-dose endotoxin infusion on changes in thoracic electrical impedances (Z0 at end-expiratory apnoea, Zmax at end-inspiration), Zmax-Z0, hematocrit (H) values, and extravascular lung water (EVLW) estimated with gravimetrical analysis (WW/DW) and the impedance method (dEVLWimp) in anesthetized dogs. To define the role of H in changes in the Z0 and Zmax, we applied splenectomy. To determine whether changes in respiration might be involved in changes in Z0 and Zmax, mechanically ventilated dogs were examined. During the infusion of endotoxin there was an increase in Z0, Zmax, H and the respiratory rate in the spontaneously breathing dogs. In splenectomized dogs both impedances slightly increased without any significant change in H. In the ventilated dogs Z0 and Zmax increased similarly, and H increased to a slightly lower level than in the spontaneously breathing dogs. In the ventilated-splenectomized dogs no changes were found in the impedances and in H. The EVLW values showed no serious edema in the endotoxemic groups. The results suggest that Z0 increased mainly in association with the increase in H. The Zmax-Z0 parameter proved to be a suitable parameter for demonstrating the changes in respiration.
New Findings in Live, Attenuated Hepatitis A Vaccine Development (1986)

Strain CR326F of hepatitis A virus, derived from a fecal specimen of Costa Rican patient 033-03, was passed 15 times in fetal rhesus monkey kidney (FRhK6) cell cultures plus eight times in human diploid lung (MRC5) cell cultures to yield variant F and 16 times in MRC5 cell cultures to yield variant F'. Both variants were purified by limit dilution passages. Virulence for marmosets was assessed at six different passage levels, including variants F and F'. There was a gradual loss of virulence with in vitro passage. Variant F retained slight virulence for marmosets; variant F' showed no evidence of virulence. Both variants induced hepatitis A antibody in most marmosets that received them, and the animals were immune to infection when challenged. Variants F and F' were also assessed in chimpanzees. As in marmosets, F retained slight virulence but F' did not. Experimental vaccines made from variants F and F' were then inoculated parenterally into adult human volunteers. A portion of recipients of variant F showed brief, low-order enzyme elevations; none was seen in recipients of F', although their occurrence could not be totally ruled out. As in the animal models, F' appeared more attenuated than F. Most persons developed hepatitis A antibody, indicating the feasibility of developing a live, attenuated hepatitis A vaccine for human beings.
Developments and perspectives of oxide-based catalysts for the oxygen evolution reaction (2014)

Activity, selectivity and stability of oxygen evolution catalysts for water electrolyzers: an interplay between composition, morphology, preparation and processing.
A 1.56GHz wide-tuning all digital FBAR-based PLL in 0.13&#x00B5;m CMOS (2010)

This paper presents the design rationale and measured results of a low power, low jitter, PVT-stable FBAR-based RF synthesizer implemented in 0.13µm CMOS. A digitally controlled FBAR oscillator, tuned with a switched-capacitor array, provides 5800ppm of frequency tuning, sufficient to cover a wide range of manufacturing and temperature variations of an FBAR. An all-digital phase-locked loop (ADPLL) is used to stabilize the FBAR DCO. In the ADPLL architecture, we introduce a two-stage time-to-digital converter (TDC) to detect phase differences between reference and divider clocks. The solution offers a fine TDC resolution without large and power-hungry TDC circuitry typically used to address in-band phase noise requirements. With the tuning range, the power consumption of 2.8 mW, and an integrated RMS jitter of 0.38ps from 10kHz to 20MHz, the FBAR ADPLL provides a PVT-stable, high quality RF frequency reference for a range of low power, high data rate applications.
Measurement of diffusion coefficients of C18 unsaturated fatty acid methyl esters, naphthalene, and benzene in supercritical carbon dioxide by a tracer response technique (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasurement of diffusion coefficients of C18 unsaturated fatty acid methyl esters, naphthalene, and benzene in supercritical carbon dioxide by a tracer response techniqueToshitaka. Funazukuri, Sumito. Hachisu, and Noriaki. WakaoCite this: Anal. Chem. 1989, 61, 2, 118–122Publication Date (Print):January 15, 1989Publication History Published online1 May 2002Published inissue 15 January 1989https://pubs.acs.org/doi/10.1021/ac00177a008https://doi.org/10.1021/ac00177a008research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A New Type of .mu.4-Oxo-Bridged Copper Tetramer: Synthesis, X-ray Molecular Structure, Magnetism and Spectral Properties of (.mu.4-Oxo)tetrakis(.mu.-bromo)bis(.mu.-2,6-bis(morpholinomethyl)-4-methylphenolato)tetracopper(II) and (.mu.4-Oxo)tetrakis(.mu.-benzoato)bis(.mu.-2,6-bis(morpholinomethyl)-4-methylphenolato)tetracopper(II) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Type of .mu.4-Oxo-Bridged Copper Tetramer: Synthesis, X-ray Molecular Structure, Magnetism and Spectral Properties of (.mu.4-Oxo)tetrakis(.mu.-bromo)bis(.mu.-2,6-bis(morpholinomethyl)-4-methylphenolato)tetracopper(II) and (.mu.4-Oxo)tetrakis(.mu.-benzoato)bis(.mu.-2,6-bis(morpholinomethyl)-4-methylphenolato)tetracopper(II)Stephan Teipel, Klaus Griesar, Wolfgang Haase, and Bernt KrebsCite this: Inorg. Chem. 1994, 33, 3, 456–464Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ic00081a011https://doi.org/10.1021/ic00081a011research-articleACS PublicationsRequest reuse permissionsArticle Views372Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Strong Correlation between SHAPE Chemistry and the Generalized NMR Order Parameter ( <i>S</i> <sup>2</sup> ) in RNA (2008)

The functions of most RNA molecules are critically dependent on the distinct local dynamics that characterize secondary structure and tertiary interactions and on structural changes that occur upon binding by proteins and small molecule ligands. Measurements of RNA dynamics at nucleotide resolution set the foundation for understanding the roles of individual residues in folding, catalysis, and ligand recognition. In favorable cases, local order in small RNAs can be quantitatively analyzed by NMR in terms of a generalized order parameter, S2. Alternatively, SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) chemistry measures local nucleotide flexibility in RNAs of any size using structure-sensitive reagents that acylate the 2'-hydroxyl position. In this work, we compare per-residue RNA dynamics, analyzed by both S2 and SHAPE, for three RNAs: the HIV-1 TAR element, the U1A protein binding site, and the Tetrahymena telomerase stem loop 4. We find a very strong correlation between the two measurements: nucleotides with high SHAPE reactivities consistently have low S2 values. We conclude that SHAPE chemistry quantitatively reports local nucleotide dynamics and can be used with confidence to analyze dynamics in large RNAs, RNA-protein complexes, and RNAs in vivo.
The H-phosphonate approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution (1999)

A new approach to the synthesis of oligonucleotides and oligonucleotide phosphorothioates in solution is described; it is based on H-phosphonate coupling [with bis(2-chlorophenyl) phosphorochloridate 22 as the coupling agent] at –40 °C, followed by in situ sulfur transfer involving either 2-(4-chlorophenylsulfanyl)isoindole-1,3(2H)-dione 23a or 4-[(2-cyanoethyl)sulfanyl]morpholine-3,5-dione 26. The yields of the coupling and sulfur transfer reactions are virtually quantitative and, following unblocking by previously reported procedures, very pure products (d[ApC], d[TpGpApC], d[TpGp(s)ApC], d[Gp(s)A] and d[Cp(s)Tp(s)Gp(s)A]) are obtained.
Analysis, Design and Experimental Results of a High-Frequency Power Supply for Spark Erosion (2005)

The LC/sub s/C/sub p/ resonant converter finds a new application in an electrical discharge machining (EDM) power supply, which is designed for the purpose of developing small size EDM systems. The switching frequency is tuned to the natural resonant frequency where the converter tends to act as a current source. In this way, three effects are achieved: 1) the necessary over-voltage is generated, first to ionize the dielectric and then to establish the electric discharge, 2) a constant current is supplied during the machining of the workpiece, providing the circuit with inherent protection under short circuit conditions, and 3) overall stability is guaranteed despite the equivalent negative resistance of the dielectric breakdown. The proposed control achieves an optimum and stable operation using tap water as dielectric fluid preventing the generation of undesired impulses and keeping the distance between the electrode and the workpiece within the optimum stable range. The EDM power supply has been validated to perform operations in a nuclear power plant application.
Heraldry : Two Oxfordshire Discoveries (1929)

Journal Article Heraldry : Two Oxfordshire Discoveries Get access E. E. Cope E. E. Cope Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLVII, Issue jul27, 27 July 1929, Pages 59–60, https://doi.org/10.1093/nq/CLVII.jul27.59 Published: 27 July 1929
Isothermal flow in an optical fiber coating applicator and die system (2006)

The isothermal flow generated by a fast-moving optical fiber in a coating applicator and die was studied numerically. Although it is expected that thermal effects can be important in typical coating processes, the isothermal flow behavior should be thoroughly investigated before including the heat transfer considerations. Thus, isothermal flow is studied in this paper, and key parameters that play a major role in the optical fiber coating process are investigated in detail. The coupled partial differential equations that govern the fluid flow are solved on a transformed nonuniform staggered grid. A finite volume method is employed with a semi implicit method for pressure linked equations (SIMPLE)-based algorithm for the pressure calculations. The fiber speed is varied from 0.1 up to 22 m/s, and various applicator sizes are considered. The diameters at the die entrance and at the die exit are varied separately, since the geometry of the applicator and of the die can play an important role. Both free and solid wall surfaces are taken for the boundary condition at the top surface in the applicator. The shear-free condition can be regarded as direct contact of the coating fluid with the cooling gas at the top surface. Three different viscosities were chosen, based on reference temperatures, taken as the fluid inlet temperature, the fiber inlet temperature, and the average temperature. Relatively low pressure differences, compared to those in the applicator and the die, were found at the dynamic contact point where the fiber first enters the coating applicator. This suggests that air or gases used for cooling the fiber may be able to enter through this location. It was also found that the shear rates in this region are comparatively higher. The temperature-dependent viscosities were found to be of critical importance in the flow. The change in size of the applicator did not significantly affect the mass flow rates at the die exit, whereas the pressure gradients and shear rates near the dynamic contact point were strongly affected. The flow field in the die changed substantially with a change in the exit size. Maximum pressures and shear rates in the die increased drastically when the die exit became smaller. This study also suggests that a more accurate representation of the upper meniscus is needed to simulate flow near the fiber entry into the applicator.