gebhart/patrepeval huggingface dataset:
Inhibition of <i>S</i>-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation (1984)

Several congeners of methylglyoxal bis(guanylhydrazone) were tested for their ability to inhibit eukaryotic putrescine-activated S-adenosylmethionine decarboxylase (EC 4.1.1.50) and intestinal diamine oxidase (EC 1.4.3.6). All the compounds tested, namely methylglyoxal bis(guanylhydrazone), ethylglyoxal bis(guanylhydrazone), dimethylglyoxal bis(guanylhydrazone) and the di-N"-methyl derivative of methylglyoxal bis(guanylhydrazone), were strong inhibitors of both yeast and mouse liver adenosylmethionine decarboxylase activity in vitro. The enzyme from both sources was most powerfully inhibited by ethylglyoxal bis(guanylhydrazone). All the diguanidines likewise inhibited diamine oxidase activity in vitro. The maximum intracellular concentrations of the ethyl and dimethylated analogues achieved in activated lymphocytes were only about one-fifth of that of the parent compound. However, both derivatives appeared to utilize the polyamine-carrier system, as indicated by competition experiments with spermidine.
Hair Growth Promotion Activity and Its Mechanism of<i>Polygonum multiflorum</i> (2015)

Polygonum multiflorum Radix (PMR) has long history in hair growth promotion and hair coloring in clinical applications. However, several crucial problems in its clinic usage and mechanisms are still unsolved or lack scientific evidences. In this research, C57BL/6J mice were used to investigate hair growth promotion activity and possible mechanism of PMR and Polygonum multiflorum Radix Preparata (PMRP). Hair growth promotion activities were investigated by hair length, hair covered skin ratio, the number of follicles, and hair color. Regulation effects of several cytokines involved in the hair growth procedure were tested, such as fibroblast growth factor (FGF-7), Sonic Hedgehog (SHH), β-catenin, insulin-like growth factor-1 (IGF-1), and hepatocyte growth factor (HGF). Oral PMR groups had higher hair covered skin ratio (100 ± 0.00%) than oral PMRP groups (48%~88%). However, topical usage of PMRP had about 90% hair covered skin ratio. Both oral administration of PMR and topically given PMRP showed hair growth promotion activities. PMR was considered to be more suitable for oral administration, while PMRP showed greater effects in external use. The hair growth promotion effect of oral PMR was most probably mediated by the expression of FGF-7, while topical PMRP promoted hair growth by the stimulation of SHH expression.
八、九世紀唐日文化交流探索─以人物交流及禮令之影響為主 (2015)

拙稿旨在研究八、九世紀唐日文化交流，除了人物交流所帶動的文化交流，尚側重禮與令的影響，注重法制與禮俗的層面。八、九世紀，正是律令制在唐日，甚至東亞地區有力運作的時期，日人基於外交需要及對唐文化的實際需求，而由官方派出遣唐使、遣唐留學僧與留學生等人物赴唐直接學習唐文化，帶回所需文物，成為唐文化在日本擴大影響力的重要原因。此類人物日後也多半是日本政治與文化上的代表性人物，亦即文化交流過程中，媒介人物跨越國境活動，成為帶動文化交流的主要媒介。此外，最近新發現的宋《天聖令》，關係到日本《大寶令》、《養老令》的修撰，而八世紀前後的日本，能夠以唐朝禮令為學習對象，又和渡唐日人在唐見聞、所獲情報甚有關聯，故值得重視。
拙稿在上篇中首先討論八、九世紀之間，日本對唐代中國文化認同狀況，探討人物交流所帶動的文化現象，以及唐文化對日本社會造成的影響。過去先行研究中所注意到的渡日唐人，多為官員、唐僧、海商及混血兒等，或許因為受限於史料甚少，而無法觀照到一般民眾的存在，本次從珍稀史料中發現前人未注意到的渡日民眾，擴大了唐日人物交流的層面，故拙稿中對於日本對唐人入境的法制管理及唐人赴日動機亦進行分析。
人物越境後的見聞，除可補充過去傳世史料的不足，佐證唐日之間曾經存在頻繁的人物與文化交流，透過比較史學的技巧，分析唐與日本境內法制施行、變動經過，以及禮制施行的狀況，可更加釐清此類人物返日後的文化影響力。另一方面，渡日唐人的體驗、抵日後的際遇，也可佐證渡唐日人返國後在文化上，尤其是法制方面的影響力。
拙稿從下篇起，將研究核心集中在唐日《喪葬令》與相關禮制問題，分析探討禮令在社會生活中的意義，從實例中解析《喪葬令》、《假寧令》、唐的《祠令》和日本的《神祇令》等，以了解當時唐朝先進文化的影響力，以及日本古代國家自主性的特色。日本因積極從事古代國家建設，在攝取先進的唐代律令禮制過程中，其實是衡量其國情，作選擇性採用。從下篇第三章以下，將逐章說明唐的禮令文化對日本原有習俗所造成影響或變化，例如唐日服制與親等的差別、唐日喪葬禮俗中，唐的挽歌與日本的遊部各自的特色、天皇為尊親服喪、穢惡問題與《服忌令》的出現，進而凸顯唐日文化交流史上法制禮俗的層面。
綜合以上，可知日本攝取唐朝法制禮俗文化以後，經過時代的洗禮，終於融合為一，成為新的日本文化傳統，延續至今。
Applying Case Definition Criteria to Irritable Bowel Syndrome (2008)

Only a small percentage of IBS cases with assigned diagnostic codes met case definition criteria for IBS. There were low concordance rates among the three diagnostic criteria applied.
α <sub>v</sub> β <sub>3</sub> Integrin Induces Tyrosine Phosphorylation–Dependent Ca <sup>2+</sup> Influx in Pulmonary Endothelial Cells (2000)

The endothelial alpha(v)beta(3) integrin occurs luminally, where its ligation by soluble agents may induce inflammatory signaling. We tested this hypothesis in bovine pulmonary artery endothelial cell monolayers with the use of vitronectin and cross-linking antibodies to ligate and aggregate the integrin. We quantified the endothelial cytosolic Ca(2+) concentration ([Ca(2+)](i)) according to the Fura 2 ratio imaging method in single cells of confluent monolayers. At baseline, endothelial [Ca(2+)](i) levels remained steady at 86 nmol/L for >20 minutes. Cross-linking of the alpha(v)beta(3) integrin through the sequential exposure of monolayers to anti-alpha(v)beta(3) monoclonal antibody LM609 and secondary IgG resulted in a [Ca(2+)](i) increase of 100% above baseline. This increase commenced in <0.5 minute, peaked in <2 minutes, and decayed to baseline in approximately 5 minutes. Similar responses occurred after the addition of vitronectin (400 microg/mL). In contrast, external Ca(2+) depletion blunted the cross-linking-induced [Ca(2+)](i) increase by 60%, a response that was completely inhibited when the monolayers were also pretreated with thapsigargin. Thus, the [Ca(2+)](i) increase was attributable in part to the release of Ca(2+) from endosomal stores but mostly to Ca(2+) influx across the plasma membrane. Induced aggregation of the alpha(v)beta(3) integrin enhanced tyrosine phosphorylation of phospholipase C-gamma1 and increased the accumulation of inositol-1, 4,5-trisphosphate. Genistein, a broad-spectrum tyrosine kinase inhibitor, abrogated both of these effects, as well as the alpha(v)beta(3)-induced [Ca(2+)](i) increases. We conclude that aggregation of the endothelial alpha(v)beta(3) integrin induces a rapid tyrosine phosphorylation-dependent increase in [Ca(2+)](i). This response may subserve the inflammatory role of alpha(v)beta(3) integrin in blood vessels.
Biotransformation of Monoterpenes by Mentha Cell Lines (1983)

Previous results indicated that all tested cell suspension lines derived from various Mentha chemotypes were capable to biotransform (-) menthone to (+)-neomentol but only some of these lines converted (+)-pulegone to (+)-isomenthone. In order to quest whether only the natural secondary metabolites or also other compounds with similarities to pulegone are biohydrogenated by Mentha cell suspensions, we incubated such suspensions with 5 unsaturated alpha-beta; ketones. No conversion was detected when mesityl oxide, trans-6-tert. butyl pulegone or 3-isopropylidine-9-methyl-decalone-2 were incubated with Mentha cells, while saturation of the alpha-beta double bond of 2-isopropylidine cyclohexanone and of trans-6-methyl pulegone was observed in suspensions of those cell lines which are capable of pulegone transformation. Suspensions of Mentha cell lines which were incapable to hydrogenate pulegone did not biotransform the two latter pulegone analogues.
Human Posture Recognition Based on Images Captured by the Kinect Sensor (2016)

In this paper we combine several image processing techniques with the depth images captured by a Kinect sensor to successfully recognize the five distinct human postures of sitting, standing, stooping, kneeling, and lying. The proposed recognition procedure first uses background subtraction on the depth image to extract a silhouette contour of a human. Then, a horizontal projection of the silhouette contour is employed to ascertain whether or not the human is kneeling. If the figure is not kneeling, the star skeleton technique is applied to the silhouette contour to obtain its feature points. We can then use the feature points together with the centre of gravity to calculate the feature vectors and depth values of the body. Next, we input the feature vectors and the depth values into a pre-trained LVQ (learning vector quantization) neural network; the outputs of this will determine the postures of sitting (or standing), stooping, and lying. Lastly, if an output indicates sitting or standing, one further, similar feature identification technique is needed to confirm this output. Based on the results of many experiments, using the proposed method, the rate of successful recognition is higher than 97% in the test data, even though the subjects of the experiments may not have been facing the Kinect sensor and may have had different statures. The proposed method can be called a “hybrid recognition method”, as many techniques are combined in order to achieve a very high recognition rate paired with a very short processing time.
Identification of the autophosphorylation sites in rhodopsin kinase. (1992)

Rhodopsin kinase (RK) is a second-messenger-independent protein kinase that is involved in deactivation of photolyzed rhodopsin (Rho*). We have developed a significantly improved method for isolation of RK based on the specific interactions of phosphorylated forms of the enzyme with heparin-Sepharose. Conversion of the dephosphorylated form of RK to the fully phosphorylated enzyme leads to specific elution of the kinase from the resin. Limited proteolysis of RK with endoproteinase Asp-N removes the phosphorylation sites. Peptides containing the autophosphorylation sites were isolated by reverse-phase high performance liquid chromatography and analyzed by Edman degradation and tandem mass spectrometry. The derived amino acid sequence of the peptide containing the major autophosphorylation site yielded the following sequence: DVGAFS488T489VKGVAFEK, where Ser488 and Thr489 are phosphorylated. Additionally, a minor autophosphorylation site was identified at Ser21. A 15-residue peptide (DVGAFSTVKGVAFEK) encompassing the major autophosphorylation site was synthesized and used for phosphorylation and inhibition studies. In contrast to many other protein kinases, the low catalytic activity of RK toward its autophosphorylation site peptide and the poor inhibitory properties of this peptide suggest unique properties of this member of the family of G protein-coupled receptor kinases.
Three-dimensional imaging and recognition of microorganism using single-exposure on-line (SEOL) digital holography (2005)

We address three-dimensional (3D) visualization and recognition of microorganisms using single-exposure on-line (SEOL) digital holography. A coherent 3D microscope-based Mach-Zehnder interferometer records a single on-line Fresnel digital hologram of microorganisms. Three-dimensional microscopic images are reconstructed numerically at different depths by an inverse Fresnel transformation. For recognition, microbiological objects are segmented by processing the background diffraction field. Gabor-based wavelets extract feature vectors with multi-oriented and multi-scaled Gabor kernels. We apply a rigid graph matching (RGM) algorithm to localize predefined shape features of biological samples. Preliminary experimental and simulation results using sphacelaria alga and tribonema aequale alga microorganisms are presented. To the best of our knowledge, this is the first report on 3D visualization and recognition of microorganisms using on-line digital holography with single-exposure.
Parking Reservation for Managing Downtown Curbside Parking (2015)

This paper discusses a smartphone-based parking reservation system that manages a finite number of curbside parking spaces located at various places in a downtown area. Parking reservation schemes are designed to minimize the total social cost of parking, which is assumed to be a weighted sum of the cruising times for drivers to travel from their current locations to allocated parking spaces and the walking times from parking places to final destinations. With the assumption of perfect information on cruising and walking times, a simple reservation scheme to achieve an optimum allocation of parking spaces is presented. However, although the locations of drivers can be retrieved from their smart-phones, it is shown that drivers have an incentive to misreport their final destinations for their own benefit, which compromises the system benefit. Thus, the Vickrey–Clark–Groves mechanism is applied to determine the allocation of parking spaces and parking fees to minimize the total social cost while ensuring that all drivers report their final destinations truthfully. Last, a revenue redistribution scheme to reduce drivers' financial burden further and increase public acceptance of the reservation system is discussed.
Cellulose supported cuprous iodide nanoparticles (Cell-CuI NPs): a new heterogeneous and recyclable catalyst for the one pot synthesis of 1,4-disubstituted – 1,2,3-triazoles in water (2014)

Cellulose supported cuprous iodide nanoparticles (Cell-CuI NPs) have been demonstrated for the first time as an efficient heterogeneous catalyst in the click synthesis of 1,4-disubstituted 1,2,3-triazoles by a one-pot three component reaction between aralkyl/alkyl bromides, alkynes and sodium azide in water. The catalyst has been characterized by XRD, HRTEM, SEM, ICP–AES, EDS as well as IR spectroscopy. It was found to be reusable for five consecutive runs without significant loss of activity.
[New therapeutic approaches in glioblastomas]. (2005)

New therapeutic approaches based on the understanding of brain tumour biology are emerging. Signal transduction inhibitors (mainly targeted against the EGF receptor, the PI3K/Akt or the Ras/Raf pathways), proteases inhibitors and antiangiogenic agents are currently under investigations in clinical trials. The recent development of convection-enhanced delivery technique allows the administration of drugs which do not cross the blood-brain-barrier, such as selective toxins or immunostimulating oligonucleotides. This article reviews these emerging therapies currently under clinical trials in glioblastomas.
New Platforms Integrating Ethynyl-Grafted Modules for Organogels and Mesomorphic Superstructures (2004)

A methyldiacylaminophenyl core substituted with gallic derivatives and alkynyl functions has been synthesized from 2,6-diamino-4-iodotoluene. By heating the iodo and ethynyl molecules, typical columnar mesophases are observed and the C(12) synthons bearing a protected terminal alkyne group gelified acetone, via the formation of interlocked fibers which are promoted by intermolecular hydrogen bonding.
Passive mapping of acoustic sources within the human skull cavity with a hemispherical sparse array using computed tomography-based aberration corrections (2014)

Traditionally, the use of ultrasound (US) in the brain has been limited by the skull bone, which presents unique challenges for both transcranial therapy and imaging due to its attenuating and aberrating effects, which become more prevalent at higher US frequencies. On transmit, these skull-induced aberrations can be overcome through the use of large-aperture phased array transducers with appropriate driving frequencies, combined with computed tomography (CT)-based bone morphology and numerical models to derive element driving signals which minimize the distortions. Recently, we have demonstrated in silico that an analogous approach can be performed during beamforming on receive, to allow for passive acoustic imaging over a large region within the skull cavity [Jones et al., Phys. Med. Biol. 58, 4981–5005 (2013)]. We will present preliminary results obtained from applying this technique experimentally with a hemispherical (30 cm diam.) sparse receiver array (128 piezo-ceramic elements, 2.5 mm diam., and 612 kHz center frequency) to image acoustic sources through an ex vivo human skullcap. Images produced using non-invasive CT-based skull corrections will be compared with those obtained through an invasive hydrophone-based correction approach, and with images formed without skull-specific corrections. This technique has promising applications in both cavitation-mediated transcranial focused ultrasound therapies, by providing a method for treatment monitoring and control, as well as in ultrasound angiographic imaging of the brain.
Software model of a machine vision system based on the common house fly. (2005)

The vision system of the common house fly has many properties, such as hyperacuity and parallel structure, which would be advantageous in a machine vision system. A software model has been developed which is ultimately intended to be a tool to guide the design of an analog real time vision system. The model starts by laying out cartridges over an image. The cartridges are analogous to the ommatidium of the fly's eye and contain seven photoreceptors each with a Gaussian profile. The spacing between photoreceptors is variable providing for more or less detail as needed. The cartridges provide information on what type of features they see and neighboring cartridges share information to construct a feature map.
High-speed analog spatial light modulator using a hydrogenated amorphous silicon photosensor and an electroclinic liquid crystal (1989)

A high-speed optically addressed spatial light modulator is described which uses the electroclinic effect in chiral smectic A liquid crystals with a p-i-n photodiode of hydrogenated amorphous silicon (a-Si:H). The near microsecond response time is a function of the liquid-crystal mixture and temperature. We present and analyze optical modulation measurements of a device which exhibits a response time of 40 μs at 29 °C and 4 μs at 50 °C. The optical response is continuous and linear with electric field and write-light intensity, allowing for grey level applications.
Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study. (2007)

A decline in serum total cholesterol levels may be associated with early stages in the development of dementia.
Frequency Domain-DFE coupled with Common Phase Error Tracking Loop in OFDM Systems (2005)

OFDM systems are very sensitive to the phase noise. The phase noise in OFDM has two side effects: common phase error (CPE) and intercarrier interference (ICI). Especially, the rotation of constellation caused by CPE may be fatal in coherent schemes. This paper suggests an equalizer coupled with a phase tracking algorithm to combat frequency selectivity and to correct CPE. Computer simulations prove that CPE can be reduced by the phase tracking loop with low complexity.
Bis[Trinitratocerium(IV)]Chromate [Ce(N0<sub>3</sub>)<sub>3</sub>1<sub>2</sub>Cr0<sub>4</sub>; A Mild Oxidant in Organic Synthesis (1984)

Abstract Bis[trinitratocerium (IV)] chromate has been prepared and used in the oxidation of benzylic alcohols to aldehydes and ketones, α-hydroxy ketones to diketones, hydroquinone to p-benzoquinone and catechol to o-benzoquinone. Cinnamyl alcohol, piperonaloxime, and salycilaldoxime are rather resistant towards oxidation with this reagent.
Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic bacterium (2014)

Titania (TiO₂)-based nanocomposites subjected to light excitation are remarkably effective in eliciting microbial death. However, the mechanism by which these materials induce microbial death and the effects that they have on microbes are poorly understood. Here, we assess the low dose radical-mediated TiO₂ photocatalytic action of such nanocomposites and evaluate the genome/proteome-wide expression profiles of Pseudomonas aeruginosa PAO1 cells after two minutes of intervention. The results indicate that the impact on the gene-wide flux distribution and metabolism is moderate in the analysed time span. Rather, the photocatalytic action triggers the decreased expression of a large array of genes/proteins specific for regulatory, signalling and growth functions in parallel with subsequent selective effects on ion homeostasis, coenzyme-independent respiration and cell wall structure. The present work provides the first solid foundation for the biocidal action of titania and may have an impact on the design of highly active photobiocidal nanomaterials.
Engineering software under statistical quality control (1990)

Eight common misconceptions of software quality are examined and refuted. The concept of cleanroom engineering of software is introduced. Cleanroom engineering achieves intellectual control by applying rigorous, mathematics-based engineering practices, establishes an errors-are-unacceptable attitude and a team responsibility for quality, delegates development and testing responsibilities to separate teams, and certifies the software's mean time to failure through the application of statistical quality-control methods. A typical project is used to explain the concepts and procedures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
High compression ratio image compression (2002)

An image compression method is proposed. It makes use of the wavelet transform (WT) with better frequency localization and the adaptive hierarchical vector quantization (AHVQ) technique. The WT provides a multifrequency channel representation for the image from which proper coding methods can be drawn. The AHVQ technique lowers the bit rate significantly while causing no extra distortion and little extra computation. Experimental results with compression ratios of up to 100: 1 are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Integrin α2 Mediates Selective Metastasis to the Liver (2009)

Abstract Cancers display distinct patterns of organ-specific metastasis. Comparative analysis of a broad array of cell membrane molecules on a liver-metastasizing subline of B16 melanoma versus the parental B16-F0 revealed unique up-regulation of integrin α2. The direct role of integrin α2 in hepatic metastasis was shown by comparison of high versus low-expressing populations, antibody blockade, and ectopic expression. Integrin α2–mediated binding to collagen type IV (highly exposed in the liver sinusoids) and collagen type IV–dependent activation of focal adhesion kinase are both known to be important in the metastatic process. Analysis of primary colorectal cancers as well as coexisting liver and lung metastases from individual patients suggests that integrin α2 expression contributes to liver metastasis in human colorectal cancer. These findings define integrin α2 as a molecule conferring selective potential for formation of hepatic metastasis, as well as a possible target to prevent their formation. [Cancer Res 2009;69(18):7320–8]
Modeling pore-pressure evolution in organic shale under the effect of maturation (2018)

We devise a workflow to model the pore pressure increase in organic shale to better characterize the shale reservoirs. In particular, the proposed model considers the microstructure in organic shale and the volume fraction variations of rock components during the maturation. The pore pressure increase is solved based on the compressibility and volumes of pore space and pore fluids. Our modeling results agree that the evolution of organic shale’s rock-physics property during kerogen maturation is consistent with fluid expansion model that sonic velocity decrease while density changes little when unloading occurs. Presentation Date: Wednesday, October 17, 2018 Start Time: 8:30:00 AM Location: 202A (Anaheim Convention Center) Presentation Type: Oral