gebhart/patrepeval huggingface dataset:
Depression Associated With Candida albicans Infections (1984)

<h3>To the Editor.—</h3> In a recent article, Gold and Pearsall<sup>1</sup>commented, "Patients seen for evaluation of depression may have either a primary affective disorder or one secondary to some medical illness." I am writing to report that depression is commonly related to prolonged or repeated courses of broad-spectrum antibiotics or to birth control pills, which promote the overgrowth of<i>Candida albicans</i>on mucous membranes.<sup>2,3</sup> Although mechanisms involved still have not been clearly elucidated, it appears that toxins produced by excessive<i>Candida</i>growth affect various parts of the body, including the immune and endocrine systems and neurotransmitters. Depression and other disorders related to<i>C albicans</i>can be suspected from clinical history, followed by a therapeutic response to oral nystatin and a yeast-free, low-carbohydrate diet.
SI Units (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSI UnitsG. Socrates Cite this: J. Chem. Educ. 1969, 46, 11, 710Publication Date (Print):November 1, 1969Publication History Received3 August 2009Published online1 November 1969Published inissue 1 November 1969https://doi.org/10.1021/ed046p710RIGHTS & PERMISSIONSArticle Views137Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays (2004)

This paper presents a novel and comprehensive method to identify substances on the basis of electrical activity and is a substantial improvement for drug screening. The spontaneous activity of primary neuronal networks is influenced by neurotransmitters, ligands, and other substances in a similar fashion as known from in vivo pharmacology. However, quantitative methods for the identification of substances through their characteristic effects on network activity states have not yet been reported. We approached this problem by creating a database including native activity and five drug-induced oscillatory activity states from extracellular multisite recordings from microelectrode arrays. The response profiles consisted of 30 activity features derived from the temporal distribution of action potentials, integrated burst properties, calculated coefficients of variation, and features of Gabor fits to autocorrelograms. The different oscillatory states were induced by blocking neurotransmitter receptors for: (i) GABA(A); (ii) glycine; (iii) GABA(A) and glycine; (iv) all major synaptic types except AMPA, and (v) all major synapses except NMDA. To test the identification capability of the six substance-specific response profiles, five blind experiments were performed. The response features from the unknown substances were compared to the database using proximity measures using the normalized Euclidian distance to each activity state. This process created six identification coefficients where the smallest correctly identified the unknown substances. Such activity profiles are expected to become substance-specific 'finger prints' that classify unique responses to known and unknown substances. It is anticipated that this kind of approach will help to quantify pharmacological responses of networks used as biosensors.
Frequency-Based Relationship of Electrowetting and Dielectrophoretic Liquid Microactuation (2003)

Electrowetting and dielectrophoretic actuation are potentially important microfluidic mechanisms for the transport, dispensing, and manipulation of liquid using simple electrode structures patterned on a substrate. These two mechanisms are, respectively, the low- and high-frequency limits of the electromechanical response of an aqueous liquid to an electric field. The Maxwell stress tensor and an RC circuit model are used to develop a simple predictive model for these electromechanics. The model is tested by measuring electric-field-induced pressure changes within an aqueous droplet trapped between two parallel, disk-shaped electrodes immersed in a bath of immiscible, insulating oil. The experiment is an adaptation of Quincke's original bubble method for measuring the dielectric constant of a liquid. For AC voltages lower than ∼100 V-rms, the pressure data largely conform to the square-law predictions of the model. At higher voltages, this square-law behavior is no longer evident, a result consistent with the well-known contact angle saturation effect. Pressure data obtained with DC electric fields are not consistent with either the lowest frequency data (10 Hz) or with the model.
In vivo flexion/extension of the normal cervical spine (1991)

Twenty-two women (age range 25-49 years, average 30.9 years) and twenty-two men (age range 23-42 years, average 31.6 years), all healthy and asymptomatic, underwent passive flexion/extension examinations of the cervical spine. Functional x-rays were taken and analyzed using a computer-assisted method that quantified intervertebral rotations, translations, and locations of the centers of rotation for each level C1-C2-C6-C7. The aim of the study was to establish values for these parameters for a normal population as related to age and gender. In the process, a statistically significant difference was found in the average value of rotation between male and female groups at the C5-C6 level. A new parameter, the ratio between translation and rotation, was also established and may prove useful for clinical diagnoses. This parameter has a smaller error associated with it than do pure translations and may aid the clinician by helping to account for the large variation in rotatory ranges of motion within the population. This translation/rotation ratio indicated highly significant differences in the lower segments of the cervical spine between gender groups.
Corneal structure and transparency (2015)

The corneal stroma plays several pivotal roles within the eye. Optically, it is the main refracting lens and thus has to combine almost perfect transmission of visible light with precise shape, in order to focus incoming light. Furthermore, mechanically it has to be extremely tough to protect the inner contents of the eye. These functions are governed by its structure at all hierarchical levels. The basic principles of corneal structure and transparency have been known for some time, but in recent years X-ray scattering and other methods have revealed that the details of this structure are far more complex than previously thought and that the intricacy of the arrangement of the collagenous lamellae provides the shape and the mechanical properties of the tissue. At the molecular level, modern technologies and theoretical modelling have started to explain exactly how the collagen fibrils are arranged within the stromal lamellae and how proteoglycans maintain this ultrastructure. In this review we describe the current state of knowledge about the three-dimensional stromal architecture at the microscopic level, and about the control mechanisms at the nanoscopic level that lead to optical transparency.
High-speed rotary-motion feedthrough suitable for UHV applications (1981)

A rotary-motion feedthrough suitable for use in UHV at frequencies between 1200–15,000 rpm is described. The outgassing rate in operation is less than 2×10−8 torr l/s.
Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging (2010)

This study shows that prelamin A is a novel biomarker of VSMC aging and disease that acts to accelerate senescence. It therefore represents a novel target to ameliorate the effects of age-induced vascular dysfunction.
Instruction-based energy estimation methodology for asymmetric manycore processor simulations (2012)

Processor power is a complex function of device, packaging, microarchitecture, and application. Typical approaches to power simulation require detailed microarchitecture models to collect the statistical switching activity counts of processor components. In manycore simulations, the detailed core models are the main simulation speed bottleneck. In this paper, we propose an instruction-based energy estimation model for fast and scalable energy simulation. Importantly, in this approach the dynamic energy is modeled as a combination of three contributing factors: physical, microarchitectural, and workload properties. The model easily incorporates variations in physical parameters such as clock frequencies and supply voltages. When compared to commonly used cycle-level microarchitectural simulation approach with SPEC2006 benchmarks, the proposed instruction-based energy model incurred a 2.94% average error rate while achieving an average simulation time speedup of 74X for a 16-core asymmetric x86 ISA processor model with multiple clock domains operating at different frequencies.
Envelope Lipid-packing as a Critical Factor for the Biological Activity and Stability of Alphavirus Particles Isolated from Mammalian and Mosquito Cells (2010)

Alphaviruses are enveloped arboviruses. The viral envelope is derived from the host cell and is positioned between two icosahedral protein shells (T = 4). Because the viral envelope contains glycoproteins involved in cell recognition and entry, the integrity of the envelope is critical for the success of the early events of infection. Differing levels of cholesterol in different hosts leads to the production of alphaviruses with distinct levels of this sterol loaded in the envelope. Using Mayaro virus, a New World alphavirus, we investigated the role of cholesterol on the envelope of alphavirus particles assembled in either mammalian or mosquito cells. Our results show that although quite different in their cholesterol content, Mayaro virus particles obtained from both cells share a similar high level of lateral organization in their envelopes. This organization, as well as viral stability and infectivity, is severely compromised when cholesterol is depleted from the envelope of virus particles isolated from mammalian cells, but virus particles isolated from mosquito cells are relatively unaffected by cholesterol depletion. We suggest that it is not cholesterol itself, but rather the organization of the viral envelope, that is critical for the biological activity of alphaviruses.
Development of a VR therapy application for Iraq war military personnel with PTSD. (2005)

Post Traumatic Stress Disorder (PTSD) is reported to be caused by traumatic events that are outside the range of usual human experiences including (but not limited to) military combat, violent personal assault, being kidnapped or taken hostage and terrorist attacks. Initial data suggests that 1 out of 6 returning Iraq War military personnel are exhibiting symptoms of depression, anxiety and PTSD. Virtual Reality (VR) exposure therapy has been used in previous treatments of PTSD patients with reports of positive outcomes. The aim of the current paper is to specify the rationale, design and development of an Iraq War PTSD VR application that is being created from the virtual assets that were initially developed for theX-Box game entitled Full Spectrum Warrior which was inspired by a combat tactical training simulation, Full Spectrum Command.
Polymer-polymer complexation in dilute aqueous solutions: poly(acrylic acid)-poly(ethylene oxide) and poly(acrylic acid)-poly(vinylpyrrolidone) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer-polymer complexation in dilute aqueous solutions: poly(acrylic acid)-poly(ethylene oxide) and poly(acrylic acid)-poly(vinylpyrrolidone)Pradip, C. Maltesh, P. Somasundaran, R. A. Kulkarni, and S. GundiahCite this: Langmuir 1991, 7, 10, 2108–2111Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/la00058a024https://doi.org/10.1021/la00058a024research-articleACS PublicationsRequest reuse permissionsArticle Views760Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An accurate ACOSSO metamodeling technique for processor architecture design space exploration (2015)

Processor architects usually design uniprocessor or chip multiprocessor (CMP) by using a platform-based approach. One of the major challenges in this approach is to explore the exponential-size design space composed of many tunable and interacting architectural parameters. An exhaustive search of the design space is prohibitive because of the expensive run-time of simulations. So an efficient design space exploration (DSE) strategy that can fast find the multi-objective architectural configurations (points in design space) in terms of system metrics like performance and energy is needed. In this paper, we propose an accurate and efficient adaptive component selection and smoothing operator (ACOSSO) metamodel assisted NSGA-II (MA-NSGA-II) multi-objective optimization (MOO) technique for processor DSE. We show the effectiveness of our methodology by comparing with linear regression (LR), restrict cubic splines (RCS), natural cubic splines (NCS) and artificial neural network (ANN) metamodeling techniques for processor design metrics prediction and architecture optimization. The experimental results show that, the proposed methodology achieves higher prediction accuracy and better architecture optimization results.
Postoperative analgesia with parenteral opioids: Does continuous delivery utilizing a transdermal opioid preparation affect analgesic efficacy or patient safety? (1997)

There is no significant advantage to the routine use of continuous transdermal opioid delivery in patients receiving IV PCA after major orthopedic surgery.
A Stable Broadband IMPATT Amplifier (2005)

A single diode IMPATT amplifier has been demonstrated at X-band which amplifies a 200mw average power input signal by 9 dB over a 1 dB locking bandwidth of 3.7%. This result is believed to be the largest gain-bandwidth product yet achieved with a single IMPATT diode for this power level.
Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols (2016)

Little is known about how harmless Corynebacterium species that colonize the human nose and skin might impact pathogen colonization and proliferation at these sites. We show that Corynebacterium accolens, a common benign nasal bacterium, modifies its local habitat in vitro as it inhibits growth of Streptococcus pneumoniae by releasing antibacterial free fatty acids from host skin surface triacylglycerols. We further identify the primary C. accolens lipase required for this activity. We postulate a model in which higher numbers of C. accolens cells deter/limit S. pneumoniae nostril colonization, which might partly explain why children without S. pneumoniae colonization have higher levels of nasal Corynebacterium. This work narrows the gap between descriptive studies and the needed in-depth understanding of the molecular mechanisms of microbe-microbe interactions that help shape the human microbiome. It also lays the foundation for future in vivo studies to determine whether habitat modification by C. accolens could be promoted to control pathogen colonization.
Investigating parasitic capacitance cancellation for EMI suppression (2009)

This paper begins with the review of different parasitic capacitance cancellation techniques. The effectiveness of different cancellation techniques is discussed. The critical parameters and constraints for each cancellation technique are identified. The cancellation techniques are then applied to different applications based on their characteristics. Experiments are carried out to verify the analysis.
Deregulated miR‐155 promotes Fas‐mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase‐3 (2011)

The role of apoptosis in the pathogenesis of intervertebral disc degeneration (IDD) remains enigmatic. Accumulating evidence has shown that the apoptotic machinery is regulated by miRNAs. We hypothesized that miRNAs might contribute to apoptosis in IDD. We have found that 29 miRNAs were differentially expressed and miR-155 was down-regulated in degenerative nucleus pulposus (NP). The deregulation of miR-155 was further verified using real-time PCR (0.56 fold, p < 0.05). Bioinformatics target prediction identified FADD and caspase-3 as putative targets of miR-155. Furthermore, miR-155 inhibited FADD and caspase-3 expression by directly targeting their 3'-UTRs, which was abolished by mutation of the miR-155 binding sites. In vitro up-regulation of miR-155 in human NP cells by transfection with lentiviral pre-miR-155 resulted in repression of FADD and caspase-3; whereas knockdown of miR-155 with lentiviral antigomiR-155 led to over-expression of FADD and caspase-3. Also, Fas-mediated apoptosis was increased when antagonizing miR-155 and decreased when using pre-miR-155 in human NP cells. In addition, we presented direct evidence of NP cells undergoing apoptosis in IDD tissues using transmission electron microscopy analysis. Moreover, a combination of in situ hybridization (ISH) and immunohistochemistry (IHC) revealed that miR-155 expressed in the cytoplasm of human NP cells with reverse correlation with FADD and caspase-3. In summary, this is the first study addressing the underlying mechanisms of IDD in terms of apoptosis and miRNAs. Furthermore, caspase-3 is identified as a novel target of miR-155. Our results suggest that deregulated miR-155 promotes Fas-mediated apoptosis in human IDD by targeting FADD and caspase-3, implicating an aetiological and therapeutic role of miR-155 in IDD.
Krylov subspace methods for solving large unsymmetric linear systems (1981)

Some algorithms based upon a projection process onto the Krylov subspace <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper K Subscript m Baseline equals upper S p a n left-parenthesis r 0 comma upper A r 0 comma ellipsis comma upper A Superscript m minus 1 Baseline r 0 right-parenthesis"> <mml:semantics> <mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>K</mml:mi> <mml:mi>m</mml:mi> </mml:msub> </mml:mrow> <mml:mo>=</mml:mo> <mml:mi>Span</mml:mi> <mml:mo>⁡</mml:mo> <mml:mo stretchy="false">(</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>r</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:mrow> <mml:mo>,</mml:mo> <mml:mi>A</mml:mi> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>r</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:mrow> <mml:mo>,</mml:mo> <mml:mo>…</mml:mo> <mml:mo>,</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mi>A</mml:mi> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi>m</mml:mi> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>r</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:mrow> <mml:mo stretchy="false">)</mml:mo> </mml:mrow> <mml:annotation encoding="application/x-tex">{K_m} = \operatorname {Span}({r_0},A{r_0}, \ldots ,{A^{m - 1}}{r_0})</mml:annotation> </mml:semantics> </mml:math> </inline-formula> are developed, generalizing the method of Conjugate gradients to unsymmetric systems. These methods are extensions of Arnoldi’s algorithm for solving eigenvalue problems. The convergence is analyzed in terms of the distance of the solution to the subspace <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper K Subscript m"> <mml:semantics> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>K</mml:mi> <mml:mi>m</mml:mi> </mml:msub> </mml:mrow> <mml:annotation encoding="application/x-tex">{K_m}</mml:annotation> </mml:semantics> </mml:math> </inline-formula> and some error bounds are established showing, in particular, a similarity with the conjugate gradient method (for symmetric matrices) when the eigenvalues are real. Several numerical experiments are described and discussed.
Encapsulation and release of<b>α</b>-chymotrypsin from poly(glycerol adipate-co-<b>ω</b>-pentadecalactone) microparticles (2008)

Polymer-based microparticles are increasingly becoming of interest for a variety of applications including drug delivery. Recently poly(glycerol adipate) (PGA) and poly(glycol adipate-co-omega-pentadecalactone) have shown promise for delivery of dexamethasone phosphate and ibuprofen. In this paper the copolyester poly(glycol adipate-co-omega-pentadecalactone) was evaluated as a colloidal delivery system for encapsulated therapeutic proteins. Enzyme containing microparticles were prepared via the double water-in-oil-in-water (w/o/w) emulsion-solvent evaporation methodology. alpha-Chymotrypsin was used as a model proteolytic enzyme and its transfer was monitored during the emulsification process, in addition to in vitro release from formed particles. On average, 22.1 microg protein per 1 mg polymer was encapsulated, although gradual loss of activity of the protein, once released, was recorded. The work presented shows the potential of this polyester as a delivery system for enzymes via microparticles, with improvements to the system achievable via polymer and process optimization. The pendant hydroxyl groups on the polymer backbone provide future capacity for tailored alteration of the physical and chemical properties of the polymer, in addition to covalent attachment of various compounds.
Efficient Synthesis of β,γ‐Alkynyl α‐Amino Acid Derivatives by Ag(I)‐Catalyzed Alkynylation of α‐Imino Esters (2004)

Abstract The first catalytic synthesis of β,γ‐alkynyl α‐amino acid derivatives was achieved by direct addition of terminal alkynes to α‐imino esters in the presence of an Ag(I) salt under mild reaction conditions.