gebhart/patrepeval huggingface dataset:
Relation between estimates of myocardial ischemia using high resolution electrocardiography and scintigraphic images (2002)

Presents some preliminary data suggesting that acute myocardial ischemia may be uniquely detectable in the QRS complex of the high resolution ECG. It is hypothesized that acute ischemia may create functional block, leading to ischemically-altered ventricular activation patterns. The study assessed four subjects undergoing elective PTCA. A continuous 12-lead HRECG was recorded and analyzed in 1-minute segments. Changes in the HRECG between the preinflation, artery-occluded and post-deflation states took the form of abnormal intra-QRS potentials. These data were trended and compared to severity estimates of ischemia obtained during balloon occlusion by tomographic scintigraphy. The abnormal QRS potentials may predict the overall degree of myocardial ischemia and exhibit forms which are specific to the artery occluded.
Nasopharyngeal Brush Biopsies and Detection of Nasopharyngeal Cancer in a High-Risk Population (1999)

Demonstration of EBV DNA in nasopharyngeal brush biopsy specimens detects NPC with a sensitivity of at least 90% (95% confidence interval = 89.63%-91.32%) and a specificity of approximately 99% (95% confidence interval = 98.64%-98.68%). This technique merits further testing as a possible ambulatory screening strategy in high-risk populations.
Methionine-Induced Hemolytic Anemia with Methemoglobinemia and Heinz Body Formation in Erythrocytes in Cats (1985)

A cat died as a result of severe hemolytic anemia after oral administration of DL-methionine (3g/day) for 3 weeks to prevent the feline urolithiasis syndrome (FUS). To examine the toxicity of methionine against cats, 3 healthy cats were administered orally with 2g of DL-methionine daily for 20 days. As a result, many erythrocytes containing large Heinz bodies appeared in the peripheral blood of all the cats at 15 days. At 18 days, the concentration of methionine in the plasma and erythrocytes of the cats reached 9-13 mM (control; 29 μM) and 6 mM (control; 39 μM), respectively. The methemoglobin concentration also increased to 8-29%(control; 2%). Polychromatophilic erythrocytes, poikilocytes and neutrophils with cytoplasmic Dohle bodies markedly increased in number in the peripheral blood of all the cats. In addition, some erythrocytes containing basophilic stipplings appeared in the blood.All the cats showed anorexia, ataxia and cyanosis between 17-20 days. After the end of methionine administration hematocrit value in each cat began to fall in proportion to a decrease of the erythrocytes with Heinz bodies, and it decreased to 20-26% on the 10th day after the last administration. These results clearly indicate that the administration of excessive methionine to cats induces methemoglobinemia and Heinz body formation in erythrocytes, resulting in hemolytic anemia.
The Science of Bakery Products (2007)

Ever wondered why bread rises? Or why dough needs to rest? From cakes and biscuits to flat breads and standard loaves, the diversity of products is remarkable and the chemistry behind these processes is equally fascinating. The Science of Bakery Products explains the science behind bread making and other baked goods. It looks at the chemistry of the ingredients, flour treatments, flour testing and baking machinery. Individual chapters focus on the science of breads, pastry, biscuits, wafers and cakes. The book concludes with a look at some experiments and methods and goes on to discuss some ideas for the future. The Science of Bakery Products is an interesting and easy to read book, aimed at anyone with an interest in everyday chemistry.
An extraction method of hyponymy based on multiple data sources fusion (2016)

Hyponymy is one of the most critical semantic relations, which contributes magnificently to semantic dictionary, information retrieval etc. In this paper, a method of extracting hyponymy is proposed based on multiple data sources fusion, which convert the extraction of hyponymy to the extraction of hypernyms for target words. First, mining candidate hypernyms for the target words based on search engine, encyclopedia resources and core suffix words. Second, fusing the candidates from the above data sources. At last, the classification algorithm is used to filter the noise and extract the hypernyms, which is a quite mature machine learning algorithm. There is hyponymy between the target words and their correctly extracted hypernyms. The experimental results show that the highest accuracy rate of hyponymy extraction reaches 0.832 using the proposed method.
Abstract P329: The Thoracic and Abdominal Arterial Segments Are Genetically and Functionally Different (2011)

Aims: Because arterial diseases are highly specific to different segments and because smooth muscle cells (SMCs) of different branches have distinct embryological origin, we undertook a systematic effort to determine the extent of differences in gene expression between the thoracic aorta (TA) and the abdominal aorta (AA). We also correlated these expression differences with physiologic function. Methods and Results: We utilized whole genome gene expression microarrays to compare expression patterns in the rat TA and AA. We identified 161 differentially expressed genes between these two segments. Functional analysis of differences in expression by Gene Set Enrichment Analysis identified different categories of genes enriched in each section of the aorta. For example, GPCR-related genes are overrepresented in the AA, while the TA showed dramatic enrichment of gene categories linked to mitochondria and energy generation. Because GPCR functions are implicated in many vascular diseases, we confirmed the differential expression of the arterial specific Regulator of G-protein signaling - 5 (RGS5), and extended the analysis to additional members of the RGS-R4 subfamily. RGS5 was the most abundant RGS-R4 mRNA in the AA, and it was the most differentially expressed family member across all vascular beds. To analyze functional correlates to the differential expression of RGS5, we performed aortic ring contraction assays from the TA and AA. Consistent with the hypothesis that RGS5 blocks angiotensin II (Ang II) type 1 receptor signaling via increased Gα-mediated GTPase activity, Ang II-induced force generation was significantly lower in AA relative to TA. Furthermore, whole-cell voltage-gated K + current (I Kv ) analysis revealed that I Kv was significantly greater in SMCs from the AA compared to cells from TA. Kv1.5 mRNA was more highly expressed in the AA relative to the TA. Conclusions: The differential gene expression pattern between TA and AA suggests distinct differentiation pathways may explain regional specificity of arterial diseases. Specifically, the enrichment of GPCR-related genes in the AA and mitochondrial genes in the TA may account for the diverse physiological function of these two distinct vascular segments.
Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves' disease. (1993)

Graves' disease is frequently aggravated during antithyroid drug therapy; however, little is known of its aggravating factors. We studied 83 patients with Graves' disease who were euthyroid for at least 6 months under antithyroid maintenance therapy, and we examined the relationship between thyrotoxicosis relapse, attack of allergic rhinitis, and peripheral eosinophil increase. Forty-one patients showed thyrotoxicosis relapse; of these, 22 (54%) showed peripheral eosinophil increase, and 14 (34%) had attacks of allergic rhinitis. In the remaining 42 patients without thyrotoxicosis relapse, only 4 (10%, P < 0.001) showed an increase in peripheral eosinophils, and only 3 (7%, P < 0.01) had allergic rhinitis. Recurrence of thyrotoxicosis was observed with the increase in serum levels of TSH-receptor antibodies and increase in eosinophils 2 months after the attack of allergic rhinitis. Three patients with seasonal allergic rhinitis showed thyrotoxicosis relapse at the same time of year within 2 consecutive years. Our findings indicate that allergic rhinitis can be an aggravating factor of Graves' disease and suggest that the preceding increase in peripheral eosinophils can be a predictive indicator of recurrence of thyrotoxicosis during antithyroid drug therapy.
760 Mbit/s Serial MSK Microwave Modem (1980)

Serial modulation and demodulation provide a significant simplification in the hardware realization of high data rate MSK systems. The serial MSK (SMSK) technique results in theoretical performance charateristics identical to conventional MSK. A 750 kbit/s low data rate system and a 760 Mbit/s high data rate system were constructed to evaluate the feasibility of the design concepts. The low data rate system had an overall BER performance degradation of 1.3 dB at a 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> BER. The 760 Mbit/s system had a corresponding degradation of 2.0 dB and used direct modulation and demodulation at the 14.7 GHz carrier.
Edge-Aware Gradient Domain Optimization Framework for Image Filtering by Local Propagation (2014)

Gradient domain methods are popular for image processing. However, these methods even the edge-preserving ones cannot preserve edges well in some cases. In this paper, we present new constraints explicitly to better preserve edges for general gradient domain image filtering and theoretically analyse why these constraints are edge-aware. Our edge-aware constraints are easy to implement, fast to compute and can be seamlessly integrated into the general gradient domain optimization framework. The improved framework can better preserve edges while maintaining similar image filtering effects as the original image filters. We also demonstrate the strength of our edge-aware constraints on various applications such as image smoothing, image colorization and Poisson image cloning.
Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. (1988)

The mechanism of charybdotoxin (CTX) block of single Ca2+-activated K+ channels from rat muscle was studied in planar lipid bilayers. CTX blocks the channel from the external solution, and K+ in the internal solution specifically relieves toxin block. The effect of K+ is due solely to an enhancement of the CTX dissociation rate. As internal K+ is raised, the CTX dissociation rate increases in a rectangular hyperbolic fashion from a minimum value at low K+ of 0.01 s-1 to a maximum value of approximately 0.2 s-1. As the membrane is depolarized, internal K+ more effectively accelerates CTX dissociation. As the membrane is hyperpolarized, the toxin dissociation rate approaches 0.01 s-1, regardless of the K+ concentration. When internal K+ is replaced by Na+, CTX dissociation is no longer voltage dependent. The permeant ion Rb also accelerates toxin dissociation from the internal solution, while the impermeant ions Li, Na, Cs, and arginine do not. These results argue that K ions can enter the CTX-blocked channel from the internal solution to reach a site located nearly all the way through the conduction pathway; when K+ occupies this site, CTX is destabilized on its blocking site by approximately 1.8 kcal/mol. The most natural way to accommodate these conclusions is to assume that CTX physically plugs the channel's externally facing mouth.
A Proposed Classification and Scoring System for Supraglottic Sealing Airways: A Brief Review (2004)

We provide an approach to evaluating sealing supraglottic airways by using a classification based on a sealing mechanism. Three main sealing mechanisms are identified, thus defining three groups: cuffed perilaryngeal sealers, cuffed pharyngeal sealers, and uncuffed anatomically preshaped sealers. We provide a brief overview of supraglottic airways and present a scoring system that is relevant to particular requirements. Scoring airways for routine applications is the example provided.
Sexual Dysfunction and Psychotropic Medications (2006)

Psychotropic drugs are often associated with sexual dysfunction. The frequency of antidepressant-associated sexual dysfunction is greatly underestimated in clinical trials that rely on patient self-report of these adverse events. Direct inquiry reveals that delayed orgasm/ejaculation occurs in >50% and anorgasmia in at least one third of patients given selective serotonin reuptake inhibitors. Antidepressant-induced sexual dysfunction can be successfully managed. A different antidepressant without significant sexual effects, such as bupropion or mirtazapine, can often be substituted. Other strategies involve drug holidays or adjunctive therapy with drugs such as sildenafil. Dopamine antagonist antipsychotic drugs are most commonly associated with decreased libido. The newer atypical antipsychotics, with less effect on dopamine, are less commonly associated with sexual dysfunction. Sexual dysfunction is commonly reported with seizure disorders, and many anticonvulsant drugs affect levels of sex hormones. Because sexual dysfunction can be related to many factors, care must be taken to establish the patient's baseline sexual functioning before the initiation of psychotropic drug therapy and to rule out other etiologies before drugs are implicated as causative.
Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. (1987)

Thrombospondin (TSP) is a multifunctional platelet glycoprotein synthesized by a variety of cells in culture including monocytes and macrophages. We now report that 125I-TSP binds specifically, saturably, and reversibly to mouse peritoneal macrophages and to cells of the monocyte-like human cell line U937 with dissociation constants of 6.7-14.5 X 10(-8) M and 3-4 X 10(5) binding sites per cell. TSP mediates an adhesive interaction between thrombin-stimulated platelets and both U937 cells and human blood monocytes. Using a sensitive rosetting assay, we found that monocytes were not rosetted by resting platelets whereas greater than 90% were rosetted by thrombin-stimulated platelets. Monoclonal and polyclonal anti-TSP antibodies markedly inhibited rosetting as did TSP itself. Neither control antibodies nor heparin, fibronectin, fibrinogen, nor the fibronectin adhesion tetrapeptide Arg-Gly-Asp-Ser inhibited rosetting. TSP may thus serve as a molecular bridge linking activated platelets with monocytes at sites of early vascular injury. Such interaction may be of critical importance in the regulation of thrombosis and the initiation of atherosclerosis.
Clinicopathological significance of loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in China (2005)

Frequent microsatellite alterations exist in HCC. LOH, which represents a tumor suppressor gene pathway, plays a more important role in hepatocarcinogenesis. MSI, which represents a mismatch repair gene pathway, is a rare event during liver carcinogenesis. Furthermore, LOH on certain chromosome regions may be correlated with clinicopathological characteristics in HCC.
Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication (2012)

Our study identifies a number of novel ISGs contributing to the suppression of HCV replication by type I and type II IFN. We demonstrate a substantial overlap of antiviral programs triggered by either cytokine and show that suppression of HCV replication is mediated by the concerted action of multiple effectors.
The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts. (1993)

The v-Rel oncoprotein of the avian Rev-T retrovirus is a member of a family of related transcription factors, which also includes the subunits of NF-kappa B and several other interacting cellular proteins. We show here that v-Rel specifically increased expression from a reporter plasmid containing multiple Sp1 binding sites approximately sixfold in chicken embryo fibroblasts (CEFs), even though v-Rel did not bind directly to these sites. v-Rel also increased expression from a reporter plasmid containing a human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in which the kappa B binding sites were mutated but which still contained intact Sp1 binding sites. The increase in Sp1-site transactivation does not precisely correlate with transformation by v-Rel since one non-transforming v-Rel mutant still induced expression from the Sp1 site-containing promoter. v-Rel appears to increase expression from Sp1 site-containing promoters by affecting the transactivation domain of Sp1, since v-Rel increased the activity of a Gal4-Sp1 fusion protein, which contains the Sp1 transactivation domain but lacks the Sp1 DNA-binding domain. As compared with v-Rel, c-Rel induced only a slight increase in expression from the reporter plasmid containing Sp1 sites. However, v-Ras and v-Src (but not v-Myb) induced increases in transcription from the reporter plasmid containing Sp1 sites to the same extent as v-Rel, but through pathways that appear to be independent from v-Rel. These results suggest that certain oncoproteins might increase transcription from many genes that contain Sp1 binding sites, and that this might be important for certain aspects of transformation by these proteins.
Lock-Free and Wait-Free Slot Scheduling Algorithms (2013)

Scalable scheduling is being increasingly regarded as an important requirement in high performance systems. There is a demand for high throughput schedulers in servers, data-centers, networking hardware, large storage systems, and in multi-cores of the future. In this paper, we consider an important subset of schedulers namely slot schedulers that discretize time into quanta called slots. Slot schedulers are commonly used for scheduling jobs in a large number of applications. Current implementations of slot schedulers are either sequential, or use locks. Sadly, lock based synchronization can lead to blocking, and deadlocks, and effectively reduces concurrency. To mitigate these problems, we propose a set of parallel lock-free and wait-free slot scheduling algorithms. Our algorithms are immune to operating system jitter, and guarantee forward progress. Additionally, all our algorithms are linearizable and expose the scheduler's interface as a shared data structure with standard semantics. We empirically demonstrate the scalability of our algorithms for a setup with thousands of requests per second on a 24 thread server. The wait free algorithms are most of the time as fast as the lock-free versions (3X-8X slower in the worst case).
[Whole organ giant section histopathologic studies on breast cancer--I. Multi-centric lesions]. (1991)

From April 1988 to January 1989, histopathologic studies by whole organ subserial sections was done in 200 mastectomy specimens of female breast carcinoma. Multicentricity was demonstrated in 40 breast, with 68 multicentric lesions, an incidence of 20%. 80% of these 68 foci were clinically occult, measuring less than or equal to 1.0 cm. 72% was histologically noninvasive whereas only 28% invasive. Among the different pathologic types, intraductal carcinoma was more common (66%) than the others. Most (85%) of the multicentric lesions in the breast had one or two foci, rarely more than two. Multicentric lesions are usually distributed in the neighboring one or two quadrants of the primary cancer, seldom throughout three or four quadrants. They were less frequently seen in the same quadrant (22.5%). The multifocal growth was not related to age or menstrual status of the patient.
Sterol and fatty acid metabolism in Fusarium oxysporum. (1977)

The effects of temperatures ranging from 10°C to 35°C on sterol and fatty acid production and hydroxymethylglutaryl CoA reductase (EC 1. 1. 1. 34, HMGCoA reductase) activity have been examined. Growth, based on dry weight, was maximal at 25°C to 30°C. Sterol production and the reductase activity were highest at 15°C after 28_??_32hr incubation when the total fatty acids were minimal. Fatty acid unsaturation generally increased with decrease in temperature.
Fightin' Words: Lexical Feature Selection and Evaluation for Identifying the Content of Political Conflict (2008)

Entries in the burgeoning “text-as-data” movement are often accompanied by lists or visualizations of how word (or other lexical feature) usage differs across some pair or set of documents. These are intended either to establish some target semantic concept (like the content of partisan frames) to estimate word-specific measures that feed forward into another analysis (like locating parties in ideological space) or both. We discuss a variety of techniques for selecting words that capture partisan, or other, differences in political speech and for evaluating the relative importance of those words. We introduce and emphasize several new approaches based on Bayesian shrinkage and regularization. We illustrate the relative utility of these approaches with analyses of partisan, gender, and distributive speech in the U.S. Senate.
Gynaecological consultation in patients with the irritable bowel syndrome. (1989)

A 12 month follow up study to assess the impact of symptoms suggestive of irritable bowel syndrome in women presenting to gynaecology clinics with pelvic pain is reported. Of 71 women 37 (52%) had symptoms suggestive of irritable bowel syndrome at presentation. A firm gynaecological diagnosis was reached in only three (8%) women positive for irritable bowel syndrome compared with 15 (44%) without (p = 0.002). After 12 months 24 (65%) women with irritable bowel syndrome were still symptomatic compared with 11 (32%) without (p = 0.01). This study shows that women with irritable bowel syndrome frequently attend gynaecological clinics but rarely have gynaecological pathology and the prognosis is poor in terms of resolution of their pain.
Nature of Surface and Bulk Defect Induced by Low Dose Oxygen Implantation in Separation by Implanted Oxygen Wafers (2001)

Two new metrologies have been proposed to characterize unknown surface and bulk defects in separation by implanted oxygen (SIMOX) wafers. They included the following: i) laser scattering particle counter plus coordinated atomic force microscope (AFM) and Cu-decoration for defect isolation and ii) cross-sectional transmission electron microscope (TEM) foil preparation using focused ion beam (FIB) and TEM investigation for defect morphology observation. Three types of surface defects were found and described as follows: i) a hole with a locally thinned top silicon layer (Park Defect A), ii) a hole formed locally without either a silicon or a buried oxide layer (Park Defect B), and iii) a hole formed with both a locally thinned top silicon and a buried oxide layer (Park Defect C). In addition, a bulk defect was found to occur as locally distributed square-shaped pits accompanied by the disappearance of the buried oxide layer (isolation defect). All surface and bulk defects in SIMOX wafers originate from oxide particle generation by electrostatic discharge and mechanical abrasion between the wafer and the pin of the wafer holder during oxygen ion implantation.