gebhart/patrepeval huggingface dataset:
Pharmacokinetics and Pharmacodynamic Effects of the Oral DPP‐4 Inhibitor Sitagliptin in Middle‐Aged Obese Subjects (2006)

Sitagliptin (MK-0431) is an oral, potent, and selective dipeptidyl peptidase-IV (DPP-4) inhibitor developed for the treatment of type 2 diabetes. This multicenter, randomized, double-blind, placebo-controlled study examined the pharmacokinetic and pharmacodynamic effects of sitagliptin in obese subjects. Middle-aged (45-63 years), nondiabetic, obese (body mass index: 30-40 kg/m2) men and women were randomized to sitagliptin 200 mg bid (n = 24) or placebo (n = 8) for 28 days. Steady-state plasma concentrations of sitagliptin were achieved within 2 days of starting treatment, and >90% of the dose was excreted unchanged in urine. Sitagliptin treatment led to approximately 90% inhibition of plasma DPP-4 activity, increased active glucagon-like peptide-1 (GLP-1) levels by 2.7-fold (P < .001), and decreased post-oral glucose tolerance test glucose excursion by 35% (P < .050) compared to placebo. In nondiabetic obese subjects, treatment with sitagliptin 200 mg bid was generally well tolerated without associated hypoglycemia and led to maximal inhibition of plasma DPP-4 activity, increased active GLP-1, and reduced glycemic excursion.
Organization and Phylogenetic Interrelationships of Genes Encoding Components of the Botulinum Toxin Complex in Proteolytic Clostridium botulinum Types A, B, and F: Evidence of Chimeric Sequences in the Gene Encoding the Nontoxic Nonhemagglutinin Component (1996)

The cluster of genes encoding components of the botulinum neurotoxin (BoNT) complex was mapped in proteolytic (group I) Clostridium botulinum strains encoding BoNT types A, B, and F. Two different arrangements of genes were found: type A strain 62A and type B strain NCTC 7273 have similar organizations of genes encoding BoNT, the nontoxic nonhemagglutinin component (NTNH), hemagglutinin components, and P-21; type F strain Langeland has genes encoding BoNT, NTNH, and P-21, and a previously unidentified open reading frame encoding a protein of 416 amino acids. A group of type A strains typified by infant strain Kyoto-F, which is unlike type A strain 62A, lacks genes for hemagglutinin components and exhibits an organization similar to that of type F. Sequencing and pairwise analysis revealed the presence of possible chimeric sequences in some NTNH genes of proteolytic C. botulinum. Discordance in genealogical trees derived from different regions of the NTNH genes was observed which could be symptomatic of recombination and which may indicate that the NTNH gene represents a hot spot for such events within the cluster of genes encoding the BoNT complex. It is also evident that the phylogenetics of the NTNH gene, which is linked to the gene encoding BoNT, does not mirror the evolutionary history of the BoNT, upon which the C. botulinum species complex is defined and subdivided.
Phase shifted multilevel amplitude-shift keying for 100 Gb/s ethernet applications (2008)

We propose a new modulation format for 100 Gb/s Ethernet applications. A plusmn49 ps/nm chromatic dispersion tolerance is achieved with a phase shifted multilevel amplitude-shift keying signal for 40 km single mode fiber transmission.
Low Temperature Plasma-Enhanced Atomic Layer Deposition of Metal Oxide Thin Films (2010)

Many reported atomic layer deposition (ALD) processes are carried out at elevated temperatures (>150°C), which can be problematic for temperature-sensitive substrates. Plasma-enhanced ALD routes may provide a solution, as the ALD temperature window can, in theory, be extended to lower deposition temperatures due to the reactive nature of the plasma. As such, the plasma-enhanced ALD of Al2O3, TiO2, and Ta2O5 has been investigated at 25–400°C using [Al(CH3)3], [Ti(OiPr)4], [Ti(CpMe)(OiPr)3], [TiCp*(OMe)3], and [Ta(NMe2)5] as precursors. An O2 plasma was employed as the oxygen source in each case. We have demonstrated metal oxide thin-film deposition at temperatures as low as room temperature and compared the results with corresponding thermal ALD routes to the same materials. The composition of the films was determined by Rutherford backscattering spectroscopy. Analysis of the growth per cycle data and the metal atoms deposited per cycle revealed that the growth per cycle is strongly dependent on the film density at low deposition temperatures. Comparison of these data for Al2O3 ALD processes in particular, showed that the number of Al atoms deposited per cycle was consistently high down to room temperature for the plasma-enhanced process but dropped for the thermal process at substrate temperatures lower than 250°C.
Spencer (1920)

Spencer Get access S. H. A. H. S. H. A. H. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-VII, Issue 135, 13 November 1920, Page 397, https://doi.org/10.1093/nq/s12-VII.135.397g Published: 13 November 1920
SCREENING OF INDIAN PLANTS FOR BIOLOGICAL ACTIVITY: PART I (1968)

Two hundred and eighty-five botanically identifide plant materials have been extracted with 50 percent ethanol and the extracts put through a wide biological screen of 61 tests. These include tests for antibacterial, antifungal, anthelminthic, antiprotozoal, anticancer, antifertillity, hypoglycaemic and a wide range of pharmacological activities.
Nature et signification phylogénétique du cotylédon (1983)

RésuméMalgré leur diversité morphologique qui est rapidement passée en revue, les cotylédons de la plupart des groupes semblent bien présenter une même nature foliaire et ne possédent pas de signification phylogénétique spécifique.En revanche, chez certaines Monocotylédones et en particulier les Glumales, l'ontogénie embryonnaire différente du cotylédon permet d'envisager celui-ci comme un vestige des structures haustoriales (pied) des embryons des Ptéridophytes dont on retrouverait, à des degrés divers, des vestiges chez divers groupes d'embryons des familles des Monocotylédones les plus archaïques (Hélobiales).Infirmant l'origine dicotylédonaire des Monocotylédones, ces résultats permettent d'émettre une hypothése qui renforce l'idée d'une filiation Ptéridophytes → Monocotylédones sans intervention d'intermédiaires dicotylés.
The priority R-tree (2008)

We present the priority R-tree, or PR-tree, which is the first R-tree variant that always answers a window query using O (( N / B ) 1−1/ d + T / B ) I/Os, where N is the number of d -dimensional (hyper-) rectangles stored in the R-tree, B is the disk block size, and T is the output size. This is provably asymptotically optimal and significantly better than other R-tree variants, where a query may visit all N / B leaves in the tree even when T = 0. We also present an extensive experimental study of the practical performance of the PR-tree using both real-life and synthetic data. This study shows that the PR-tree performs similarly to the best-known R-tree variants on real-life and relatively nicely distributed data, but outperforms them significantly on more extreme data.
Reinforcement Learning Using a Continuous Time Actor-Critic Framework with Spiking Neurons (2013)

Animals repeat rewarded behaviors, but the physiological basis of reward-based learning has only been partially elucidated. On one hand, experimental evidence shows that the neuromodulator dopamine carries information about rewards and affects synaptic plasticity. On the other hand, the theory of reinforcement learning provides a framework for reward-based learning. Recent models of reward-modulated spike-timing-dependent plasticity have made first steps towards bridging the gap between the two approaches, but faced two problems. First, reinforcement learning is typically formulated in a discrete framework, ill-adapted to the description of natural situations. Second, biologically plausible models of reward-modulated spike-timing-dependent plasticity require precise calculation of the reward prediction error, yet it remains to be shown how this can be computed by neurons. Here we propose a solution to these problems by extending the continuous temporal difference (TD) learning of Doya (2000) to the case of spiking neurons in an actor-critic network operating in continuous time, and with continuous state and action representations. In our model, the critic learns to predict expected future rewards in real time. Its activity, together with actual rewards, conditions the delivery of a neuromodulatory TD signal to itself and to the actor, which is responsible for action choice. In simulations, we show that such an architecture can solve a Morris water-maze-like navigation task, in a number of trials consistent with reported animal performance. We also use our model to solve the acrobot and the cartpole problems, two complex motor control tasks. Our model provides a plausible way of computing reward prediction error in the brain. Moreover, the analytically derived learning rule is consistent with experimental evidence for dopamine-modulated spike-timing-dependent plasticity.
Monolithic high-speed CMOS-photoreceiver (1999)

Results of optoelectronic integrated CMOS receivers for applications in optical data transmission and in optical interconnects are presented. The rise and fall times of the integrated p-i-n photodiodes (PDs) are 0.19 and 0.24 ns, respectively, corresponding to -3 dB bandwidths in excess of 1.4 GHz. These PDs combine this high speed with a high quantum efficiency. Rise and fall times of 0.53 and 0.69 ns, respectively, are obtained for CMOS optoelectronic integrated circuits (OEICs) with integrated p-i-n PD's. These OEICs in 1.0 μm CMOS technology handle a data rate of 622 Mb/s with a single-supply voltage of 3.3 V.
Comparative evaluation of text- and citation-based plagiarism detection approaches using guttenplag (2011)

Various approaches for plagiarism detection exist. All are based on more or less sophisticated text analysis methods such as string matching, fingerprinting or style comparison. In this paper a new approach called Citation-based Plagiarism Detection is evaluated using a doctoral thesis, in which a volunteer crowd-sourcing project called GuttenPlag identified substantial amounts of plagiarism through careful manual inspection. This new approach is able to identify similar and plagiarized documents based on the citations used in the text. It is shown that citation-based plagiarism detection performs significantly better than text-based procedures in identifying strong paraphrasing, translation and some idea plagiarism. Detection rates can be improved by combining citation-based with text-based plagiarism detection.
<i>p</i>-wave superconductivity in cubic metals (1985)

Group theory is used to classify p-wave superconducting states in a cubic crystal with spin-orbit coupling. All possible stable states are obtained based on the most general form of the Ginzburg-Landau free energy. Within the weak-coupling theory all stable states have real order parameters. These real states are even under time-reversal symmetry. However, in general, states with complex order parameters are also possible. In these complex states time-reversal symmetry is broken. This broken symmetry may show up through the existence of a Josephson current between a complex p-wave state and a usual s-wave superconductor. The form of the pairing in a magnetic field is also discussed.
Nickel-thiolate chemistry based on chelating ligands: controlling the course of self-assembly reactions via ligand bite distances. Synthesis, structures, and properties of the homoleptic complexes [Ni3(SCH2C6H4CH2S)4]2-, [Ni3(SCH2CH2S)4]2-, and [Ni6(SCH2CH2CH2S)7]2- (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel-thiolate chemistry based on chelating ligands: controlling the course of self-assembly reactions via ligand bite distances. Synthesis, structures, and properties of the homoleptic complexes [Ni3(SCH2C6H4CH2S)4]2-, [Ni3(SCH2CH2S)4]2-, and [Ni6(SCH2CH2CH2S)7]2-Wolfgang Tremel, Michael Kriege, Bernt Krebs, and Gerald HenkelCite this: Inorg. Chem. 1988, 27, 22, 3886–3895Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ic00295a004https://doi.org/10.1021/ic00295a004research-articleACS PublicationsRequest reuse permissionsArticle Views364Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Efficient and Flexible Cosimulation Environment for DSP Applications (1998)

Hardware software codesign using various hardware and software implementation possibilities requires a cosimulation environment which has both flexibility and efficiency. In this paper, a hardware software cosimulation environment is developed using the backplane approach and optimized synchronization. To seamlessly integrate a new simulator, this paper defines and implements the backplane protocol for communication and synchronization between client simulators. Automatic interface generation facility is also devised for more effective cosimulation environment. To enhance the performance of cosimulation backplane, a series of optimized hardware software synchronization methods are introduced. Efforts are focused on reducing control packets between simulators as well as concurrent execution of simulators without roll-back. The environment is implemented based on Ptolemy and validated with a QAM example run on different configurations. With optimized synchronization method, we have achieved about 7 times speed-up compared with the lock-step synchronization.
Enhancement mode AlGaN/GaN HFET with selectivelygrown <i>pn</i> junction gate (2000)

A report is presented into the fabrication and characterisation of an enhancement mode AlGaN/GaN heterojunction field-effect transistor (HFET) with selectively grown pn junction gate. At zero gate bias the device channel is depleted due to the high built-in potential of the gate-channel junction. The selective area growth approach enables both depletion and enhancement mode HFETs to be fabricated on the same wafer thus opening up the possibility of designing high speed, low consumption GaN-based logical integrated circuits.
Increasing plant susceptibility to <i>Agrobacterium</i> infection by overexpression of the <i>Arabidopsis</i> nuclear protein VIP1 (2002)

Agrobacterium is a unique model system as well as a major biotechnological tool for genetic manipulation of plant cells. It is still unknown, however, whether host cellular factors exist that are limiting for infection, and whether their overexpression in plant cells can increase the efficiency of the infection. Here, we examined the effect of overexpression in tobacco plants of an Arabidopsis gene, VIP1, which encodes a recently discovered cellular protein required for Agrobacterium infection. Our results indicate that VIP1 is imported into the plant cell nucleus via the karyopherin alphadependent pathway and that elevated intracellular levels of VIP1 render the host plants significantly more susceptible to transient and stable genetic transformation by Agrobacterium, probably because of the increased nuclear import of the transferred-DNA.
Remote transfer of ultrastable frequency references via fiber networks (2007)

Three distinct techniques exist for distributing an ultrastable frequency reference over optical fibers. For the distribution of a microwave frequency reference, an amplitude-modulated continuous wave (cw) laser can be used. Over kilometer-scale lengths this approach provides an instability at 1 s of approximately 3 x 10(-14) without stabilization of the fiber-induced noise and approximately 1 x 10(-14) with active noise cancellation. An optical frequency reference can be transferred by directly transmitting a stabilized cw laser over fiber and then disseminated to other optical and microwave regions using an optical frequency comb. This provides an instability at 1 s of 2 x 10(-14) without active noise cancellation and 3 x 10(-15) with active noise cancellation [Recent results reduce the instability at 1 s to 6 x 10(-18).] Finally, microwave and optical frequency references can be simultaneously transmitted using an optical frequency comb, and we expect the optical transfer to be similar in performance to the cw optical frequency transfer. The instability at 1 s for transfer of a microwave frequency reference with the comb is approximately 3 x 10(-14) without active noise cancellation and <7 x 10(-15) with active stabilization. The comb can also distribute a microwave frequency reference with root-mean-square timing jitter below 16 fs integrated over the Nyquist bandwidth of the pulse train (approximately 50 MHz) when high-bandwidth active noise cancellation is employed, which is important for remote synchronization applications.
Clinical Manifestations of Insular Lobe Seizures: A Stereo‐electroencephalographic Study (2004)

This sequence of ictal symptoms looks reliable enough to characterize insular lobe epileptic seizures (ILESs). Observation of this clinical sequence at the onset of seizures on video-EEG recordings in TLE patients strongly suggests that the seizure-onset zone is located not in the temporal but in the insular lobe; recording directly from the insular cortex should occur before making any decision regarding epilepsy surgery.
Affinity of the Highly Preorganized Ligand PDA (1,10-Phenanthroline-2,9-dicarboxylic acid) for Large Metal Ions of Higher Charge. A Crystallographic and Thermodynamic Study of PDA Complexes of Thorium(IV) and the Uranyl(VI) ion (2008)

The hydrothermal synthesis and structures of [UO2(PDA)] (1) and [Th(PDA)2(H2O)2].H2O (2) (PDA = 1,10-phenanthroline-2,9-dicarboxylic acid) are reported. 1 is orthorhombic, Pnma, a = 11.1318(7) A, b = 6.6926(4) A, c = 17.3114(12) A, V = 1289.71(14), Z = 4, R = 0.0313; 2 is triclinic, P1, a = 7.6190(15) A, b = 10.423(2) A, c = 17.367(4) A, alpha = 94.93(3) degrees , beta = 97.57(3) degrees , gamma = 109.26(3) degrees , V = 1278.3(4) A (3), Z = 2, R = 0.0654. The local geometry around the U in 1 is a pentagonal bipyramid with the two uranyl oxygens occupying the apical positions. The donor atoms in the plane comprise the four donor atoms from the PDA ligand (average U-N = 2.558 and U-O = 2.351 A) with the fifth site occupied by a bridging carboxylate oxygen from a neighboring UO2/PDA individual. The PDA ligand in 1 is exactly planar, with the U lying in the plane of the ligand. The latter planarity, as well as the near-ideal U-O and U-N bond lengths, and O-U-N and N-U-N bond angles within the chelate rings of 1 suggest that PDA binds to the uranyl cation in a low-strain manner. In 2, there are two PDA ligands bound to the Th (average Th-N = 2.694 and Th-O = 2.430 A) as well as two water molecules (Th-O = 2.473 and 2.532 A) to give the Th a coordination number of 10. The PDA ligands in 2 are bowed, with the Th lying out of the plane of the ligand. Molecular mechanics calculations suggest that the distortion of the PDA ligands in 2 arises because of steric crowding. UV spectroscopic studies of solutions containing 1:1 ratios of PDA and Th(4+) in 0.1 M NaClO4 at 25 degrees C indicate that log K1 for the Th(4+)/PDA complex is 25.7(9). The latter result confirms the previous prediction that complexes of PDA with metal ions of higher charge and an ionic radius of about 1.0 A such as Th(IV) would have remarkably high log K1 values with PDA. The origins of this very high stability are discussed in terms of a synergy between the pyridyl and the carboxylate donor groups of PDA. Metal ions of high charge normally bond poorly with pyridyl donors in aqueous solution because such metal ions require donor groups that are able to disperse charge to the solvent via hydrogen-bonding, which pyridyl groups are unable to do. In PDA, the carboxylates fulfill this need and so enable the high donor strength of the pyridyl groups of PDA to become apparent in the high log K1 for Th(IV) with PDA.
Thyroid hormone induces protein secretion and morphological changes in astroglial cells with an increase in expression of glial fibrillary acidic protein (1997)

Thyroid hormone (T3) induces in vitro differentiation of astrocytes from the developing rat brain. T3 treatment induced the appearance of long processes in cultured cerebral hemisphere and mesencephalon astrocytes from embryonic and newborn rats. T3 treatment also produced a change in the morphology of cultured cerebellar astrocytes from 10-day-old rats, but not in cerebellar astrocytes from newborn rats. An increased expression of glial fibrillary acidic protein (GFAP) was also seen in the T3-treated newborn cerebral hemisphere and mesencephalic astrocytes. The morphological changes were induced earlier when the astrocytes were treated with conditioned medium (CM) obtained from cultures previously exposed to T3. Our results show that astrocytes from the developing rat brain are not homogeneous in their responsiveness to T3. Furthermore, the fact that CM produces a response similar to that obtained with T3 treatment but in less time, suggests that T3 might induce the secretion of factors by cultured astrocytes. These factors might, by an autocrine/paracrine effect, induce the expression of GFAP and differentiation in developing brain astrocytes.
Immunoglobulin A from bronchopulmonary secretions blocks bactericidal and opsonizing effects of antibody to nontypable Haemophilus influenzae (1984)

Patients with chronic bronchitis are colonized by and may develop acute bronchopulmonary infection due to nontypable Haemophilus influenzae (NTHI) despite the presence of bactericidal and opsonizing antibody to the infecting organism. To test the hypothesis that secretory immunoglobulin A (IgA) interferes with host defense mechanisms, we extracted secretory IgA from bronchopulmonary secretions of five patients with NTHI pneumonia. NTHI was incubated with IgA before or during incubation with each patient's own serum or normal human serum. IgA from four of these individuals blocked the bactericidal and opsonizing effects of normal human serum and/or their own serum against their own and/or other NTHI. IgA from bronchopulmonary secretions of patients not infected with NTHI or from the serum of a patient with an IgA myeloma had no such effect. Blocking appeared to result from a direct interaction between IgA and the bacteria. The presumed mechanism is an interaction with bacterial surface antigens, although it is not known whether this occurs at antigenic sites responsible for bactericidal and opsonizing activity or whether interaction with adjacent antigenic sites and subsequent steric interference is responsible. This blocking effect of IgA may be one mechanism that allows for the development of NTHI colonization or pneumonia in an individual who already has seemingly adequate antibody against the infecting organism.