gebhart/patrepeval huggingface dataset:
Hematopoietic supportive function of human bone marrow stromal cell lines established by a recombinant SV40-adenovirus vector. (1994)

We have previously reported the establishment of a variety of human bone marrow stromal cell lines using a recombinant SV40-adenovirus vector. Using this vector, we obtained more clonal stromal cells. Here, we have characterized these cells and analyzed their capacity to support the proliferation and differentiation of hematopoietic cells. The stromal cells were cocultured with nonadherent human bone marrow cells used as hematopoietic cells. The total numbers of hematopoietic cells and CFU-GM in culture were counted every week. Two of the six stromal cell lines, AA101 and HAS303, supported the proliferation and differentiation of hematopoietic cells and CFU-GM for more than 9 weeks. Further, granulocytes, macrophages, and megakaryocytes were detected when cocultured with these cells. When hematopoietic cells were cocultured but separated from the two stromal cell lines by a 0.45-microns millipore membrane to prevent their attachment, almost all CFU-GM disappeared within 7 weeks. The supportive stromal cells produced GM-CSF and IL-6. However, other cell lines producing these humoral factors did not support hematopoietic cell proliferation for such a long time. These findings suggest that these established human bone marrow stromal cell lines will be useful, in that analysis of their supportive function in hematopoietic cell proliferation and differentiation through cell-to-cell interaction will shed some light on this area.
Thermographic Assessment of a Vascular Malformation of the Hand: A New Imaging Modality (2016)

Vascular malformations of the hand are rare. Angiography is the current Gold Standard imaging modality. Thermal imaging is an emerging noninvasive, noncontact technology that does not require intravenous contrast agents. We present the case of a patient with an arteriovenous malformation affecting the hand in which thermal imaging has been used as an adjunct to capture baseline images to allow monitoring of progression. We suggest that thermal imaging provides an adjunct that can be used in addition to clinical examination and/or angiography for the diagnosis and routine follow-up of conservatively managed arteriovenous malformations, to monitor progression or vascular steal, and also for recording recurrence after surgical excision for which there is known to be a significant incidence. With the benefit of being a noninvasive imaging modality that does not require intravenous contrast, or ionizing radiation exposure, office-based thermal imaging may become commonplace.
Heterogeneous Conductance Levels of Native AMPA Receptors (2000)

The single-channel properties of AMPA receptors can affect information processing in neurons by influencing the amplitude and kinetics of synaptic currents, yet little is known about the unitary properties of native AMPA receptors in situ. Using whole-cell and outside-out patch-clamp recordings from granule cells in acute cerebellar slices, we found that migrating granule cells begin to express AMPA receptors before they arrive in the internal granule cell layer and receive synaptic input. At saturating agonist concentrations, the open probability of channels in outside-out patches from migrating cells was very high, allowing us to identify patches that contained only one or two active channels. Analysis of the single-channel activity in these patches showed that individual AMPA receptors exhibit as many as four distinguishable conductance levels. The conductance levels observed varied substantially for different channels, although on average the values fell within the range of unitary conductances estimated previously for synaptic AMPA receptors. In contrast to patches from migrating granule cells, we rarely observed directly resolvable single-channel currents in patches excised from the somata of granule cells in the internal granular layer, even though these cells gave large AMPA receptor whole-cell currents. We did, however, detect AMPA receptors with apparent unitary conductances of <1 pS in patches from both migrating and mature granule cells. Our results suggest that granule cells express a heterogeneous population of AMPA receptors, a subset of which are segregated to postsynaptic sites after synaptogenesis.
A Continuum of Progress: Applications of N‐Hetereocyclic Carbene Catalysis in Total Synthesis (2012)

N-Heterocyclic carbene (NHC) catalyzed transformations have emerged as powerful tactics for the construction of complex molecules. Since Stetter's report in 1975 of the total synthesis of cis-jasmon and dihydrojasmon by using carbene catalysis, the use of NHCs in total synthesis has grown rapidly, particularly over the last decade. This renaissance is undoubtedly due to the recent developments in NHC-catalyzed reactions, including new benzoin, Stetter, homoenolate, and aroylation processes. These transformations employ typical as well as Umpolung types of bond disconnections and have served as the key step in several new total syntheses. This Minireview highlights these reports and captures the excitement and emerging synthetic utility of carbene catalysis in total synthesis.
Fish Consumption and Mortality from Coronary Heart Disease (1985)

indicate damage to the muscle and myoneural junction.Such changes do not occur in primary muscle disorders, denervation atrophy, or drug toxicity.2Similar changes at the myoneural junction have, however, been reported in Becker's type of progressive muscular dystrophy.3In the absence of other factors known to precipitate muscle damageourdata indicate that isotretinoin may induce reversible damage to skeletal muscle.Since there were no symptoms or signs of damage to the myoneural junction we refrained from performing a study of "jitter" or repetitive nerve stimulation.We cannot offer an adequate explanation for our findings, although muscle pain and stiffness are features ofchronic vitamin A toxicity.4A recent experiment showed that retinoic acid given in large doses to pregnant mice modified the phenotype expression of developing muscles in the fetus and increased creatine kinase activity.5
Realistic HDR tone-mapping based on contrast perception matching (2009)

In this paper, a new method to measure human's reaction time on local contrast is introduced. It is believed the reaction time is highly correlated with the response strength on local contrasts in human visual system. Using the proposed method, a large set of subjective viewing data were then collected, and a full-range (from near-threshold to suprathreshold) contrast perception model on low dynamic range display is built. Based on the proposed model and Plainis' reaction time model [17], a new realistic tone-mapping operator, which minimizes the perception difference of local contrasts between HDR and LDR images, is proposed. Experimental results confirmed the performance of the proposed operator.
The Oxytocin-Oxytocin Receptor System and Its Antagonists as Tocolytic Agents (2011)

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which belongs to the G-protein-coupled receptor superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. Changes in receptor levels, receptor desensitization, and locally produced oxytocin are factors that influence the effect of oxytocin on uterine contractility in labor. Activation of oxytocin receptor causes myometrial contractions by increasing intracellular Ca(+2) and production of prostaglandins. Since oxytocin induces contractions, the inhibition of its action has been a target in the management of preterm labor. Atosiban is today the only oxytocin receptor antagonist that is available as a tocolytic. However, the quest for oxytocin receptor antagonists with a better pharmacological profile has led to the synthesis of peptide and nonpeptide molecules such as barusiban, retosiban, L-368,899, and SSR-126768A. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action. In this paper, we summarize the action of oxytocin and its receptor and we present an overview of the clinical and experimental data of oxytocin antagonists and their tocolytic action.
TEM Observation of Segregated Microstructure in Sputtered Co–Cr Film (1986)

TEM observation of the segregated microstructure in sputtered Co–Cr films was conducted. The specific segregated microstructure was observed in the film composition range of 15.3–24.3 at%Cr–Co. The results present a new model for the origin of the segregation where two-phase separation into magnetic and non-magnetic phases occurs in a single hcp phase. The ferromagnetic Co-rich regions in a crystallite are supposed to be embedded in nonmagnetic Cr-rich matrix, with a wall-like figure perpendicular to the substrate plane.
A High Efficiency Algorithm of Power and Bit Allocation for OFDMA Systems (2007)

In this paper, we propose a high efficiency algorithm of power and bit allocation for orthogonal frequency division multiple access (OFDMA) system, in which the allocation procedure is divided into three parts: linear water-filling power allocation, bit allocation and power and bit adjustment. It can quickly achieve the power and bit allocation on the user's sub-carrier level with a good fairness performance. Simulation results show that the proposed algorithm can obviously decrease the operation complexity and slightly descended system throughput contrast to other algorithms. It is a promising algorithm to be used in a practical system for radio resource allocation.
Immunoexpression of perforin and granzyme B on infiltrating lymphocytes in human renal acute allograft rejection. (2004)

Graft destruction can be effected by direct cell-to-cell contact between activated effector T cell and a target graft resulting in delivery of cytotoxic molecules. Perforin and granzyme B can be used as activation markers for cytotoxic cells in allograft tissue. The aim of the study was to determine the immunoexpression of perforin and granzyme B by immune cells infiltrating renal tissue during acute allograft rejection and to evaluate any correlation between the phenotype of infiltrating lymphocytes and cells expressing cytotoxic granules as well as the severity of graft damage as defined by Banff 97 criteria. Immunoperoxidase staining was carried out using monoclonal antibodies anti-perforin, -granzyme B, -CD3 and -CD8 on renal allograft biopsy specimens from twenty one patients with acute renal transplant rejection: Banff 97 IA (n = 11) and Banff 97 IB (n = 10). As a control 11 biopsy specimens of renal transplant patient without any signs of rejection were used. All allograft biopsy specimens with acute renal transplant rejection contained a high number of CD3+ T cells (Banff IA: 437.4 +/- 154.4 and Banff IB: 825 +/- 339.9 vs 123.4 +/- 52.5 in controls) and CD8+ T lymphocytes (Banff 97 IA: 177.6 +/- 89.2 and Banff IB: 293.2 +/- 112.4 vs 64.2 +/- 37.1 in controls). Immunostaining for granzyme B and perforin was negative in controls. The immunopositivity for perforin was similar in Banff IA and Banff IB acute allograft rejection (1.5 +/- 0.6 vs 1.8 +/- 0.8, respectively). Granzyme B+ cell count was significantly higher in severe rejection group Banff IB (128.3 +/- 74.3) than in Banff IA group (48.2 +/- 18.3). Moreover, in acute allograft rejection Banff IB the number of granzyme B+ cells and perforin+ cells was correlated with the number of CD8+ T cells. In conclusion, our results suggest that in acute tubulointerstitial allograft rejection activated cytotoxic T lymphocytes play a major role. The strong immunopositivity for granzyme B on infiltrating cells in renal transplant tissue is suggested as a marker of severity of graft damage.
The Exponential Radon Transform (1980)

The exponential Radon transform, a generalization of the Radon transform, is defined and is studied as a mapping of function spaces. An inversion formula is derived. The exponential Radon transform is represented in terms of Fourier transforms of its domain and range, and this leads to a characterization of the range of the transform. The exponential Radon transform is a model for some reconstruction problems in radionuclide emission computer tomography.
Interactive Machine Learning via a GPU-accelerated Toolkit (2017)

Machine learning is growing in importance in industry, sciences, and many other fields. In many and perhaps most of these applications, users need to trade off competing goals. Machine learning, however, has evolved around the optimization of a single, usually narrowly-defined criterion. In most cases, an expert makes (or should be making) trade-offs between these criteria which requires high-level (human) intelligence. With interactive customization and optimization the expert can incorporate secondary criteria into the model-generation process in an interactive way. In this paper we develop the techniques to perform customized and interactive model optimization, and demonstrate the approach on several examples. The keys to our approach are (i) a machine learning architecture which is modular and supports primary and secondary loss functions, while users can directly manipulate its parameters during training (ii) high-performance training so that non-trivial models can be trained in real-time (using roofline design and GPU hardware), and (iii) highly-interactive visualization tools that support dynamic creation of visualizations and controls to match various optimization criteria.
A Formalin-Inactivated Vaccine Protects against Mucosal Papillomavirus Infection: A Canine Model (1994)

A formalin-inactivated canine oral papilloma homogenate was used as a vaccine to prevent infection by the oncogenic, mucosotropic canine oral papillomavirus (COPV) in beagle dogs. Twenty-six dogs received 2 doses of phosphate-buffered saline intradermally and 99 dogs received 2 doses of the inactivated vaccine. One month after the second dose all dogs were challenged with infectious COPV by scarification of the oral mucosa. All of the control dogs developed papillomas by 6-8 weeks after challenge while none of the vaccinated dogs did. This vaccine has been used successfully in approximately 60,000 line bred beagles with no untoward effects and with long-lasting protection. These data demonstrate that a systemically administered, formalin-inactivated vaccine can protect against mucosal infection by COPV and suggest approaches for the development of human papillomavirus vaccines.
Antithyroid Drugs (2005)

Antithyroid drugs, which have been available for more than half a century, are important in the management of hyperthyroidism, particularly in patients with Graves' disease, who have a high response rate. Since the responses of patients vary and these agents have potentially serious side effects, a working knowledge of their complex pharmacology is required. This review article considers recent pharmacologic and clinical data related to the use of these compounds.
Efficient reduced-order modeling of frequency-dependent coupling inductances associated with 3-D interconnect structures (1996)

Reduced-order modeling techniques are now commonly used to efficiently simulate circuits combined with interconnect, but generating reduced-order models from realistic three-dimensional (3-D) structures has received less attention. In this paper, we describe a Krylov-subspace based method for deriving reduced-order models directly from the 3-D magneto-quasistatic analysis program FastHenry. This new approach is no more expensive than computing an impedance matrix at a single frequency.
Isolation and partial characterization of the poly(A) polymerases from HeLa cells infected with vaccinia virus. (1977)

Three poly(A) polymerases were isolated from HeLa cells infected with vaccinia virus.Two were cellular enzymes.The first was a poly(A) polymerase that was located primarily in the nucleus, comprised a single polypeptide with a M, = 50,000, was stimulated by Mn2+ and also by Mg'+, and was able to use RNA, but not oligo(A), as primer.The second, which accounted for about 75% of the total cellular poly(A) polymerase activity, was located primarily in the cytoplasm, consisted of a single polypeptide with a M, = 75,000, was absolutely dependent on the presence of Mn2+, and was able to use both RNA and oligo(A) as primer.The third enzyme was present only in cells infected with vaccinia virus.It was a heterodimer composed of two polypeptides with M, = 57,000 and 37,000, was stimulated by Mn2+ and also by Mg'+, and was able to use both RNA and oligo(A) as primer.It was identical in all properties tested with the poly(A) polymerase that can be isolated from vaccinia virus cores except for somewhat different chromatographic properties, caused possibly by a charge difference.The subunits of this vaccinia virus-specified poly(A) polymerase were different not only from those of either of the two host cell poly(A) polymerases, but also from those of the vaccinia virus-specified DNA-dependent RNA polymerase; it is therefore a distinct virus-specified enzyme.No other virus-specified poly(A) polymerase was present in infected cells.
Discovery of a new intercalation-type anode for high-performance sodium ion batteries (2019)

A CoFe layered double hydroxide (LDH) pillared by nitrates as an anode for sodium ion batteries exhibits high capacity with excellent cycling stability. An exceptional intercalation/de-intercalation mechanism for Na<sup>+</sup> storage has been revealed in metal hydroxides, rather than the routinely believed conversion reaction presenting in lithium ion batteries.
Prothrombin Complex Concentrates in Trauma and Perioperative Bleeding (2015)

Abstract There is increasing interest in prothrombin complex concentrates as therapy for perioperative and trauma-related bleeding. A suitable point-of-care test is needed to guide such therapy, and randomized controlled trials are needed for robust, evidence-based recommendations.
Pressure and Phase Equilibria in Interacting Active Brownian Spheres (2015)

We derive a microscopic expression for the mechanical pressure P in a system of spherical active Brownian particles at density ρ. Our exact result relates P, defined as the force per unit area on a bounding wall, to bulk correlation functions evaluated far away from the wall. It shows that (i) P(ρ) is a state function, independent of the particle-wall interaction; (ii) interactions contribute two terms to P, one encoding the slow-down that drives motility-induced phase separation, and the other a direct contribution well known for passive systems; and (iii) P is equal in coexisting phases. We discuss the consequences of these results for the motility-induced phase separation of active Brownian particles and show that the densities at coexistence do not satisfy a Maxwell construction on P.
Assessing Tumor Angiogenesis (2004)

No markers are currently available to indicate the angiogenic profile of a specific malignant disease nor to predict response to antiangiogenic therapies. Nevertheless, many different antiangiogenic drugs are presently being tested in many clinical trials, with an obvious scarcity of useful endpoints for treatment outcome beside survival. By means of a quantitative reverse transcription-PCR approach, we measured VE-cadherin (VE-C), Tie-2, vascular endothelial growth factor receptor 2 and CD133 RNA in the blood of 14 healthy controls, 3 pregnant women, and 84 newly diagnosed (or relapsed) cancer patients. Circulating VE-C RNA was increased in pregnant women and cancer patients (P = 0.0002). VE-C RNA was particularly increased in patients affected by hematological malignancies and decreased to normal values in patients achieving complete remission. Conversely, circulating RNA levels of other endothelial or progenitor cell-specific markers Tie-2, vascular endothelial growth factor receptor 2, and CD133 were not significantly increased in either pregnant women or cancer patients. Comparison of various surrogate angiogenesis markers indicated a switch toward increased plasma vascular endothelial growth factor (VEGF) levels, viable circulating endothelial cells, and circulating VE-C RNA levels in patients affected by hematological malignancies. Taken together, our data indicate that the quantitative evaluation of circulating VE-C RNA is a specific and highly promising tool with which to investigate the angiogenic phenotype of cancer patients.
Spectral Colour Prediction Model for a Transparent Fluorescent Ink on Paper (1998)

A new spectral colour prediction model for a fluorescent ink printed on paper is presented. It is based on our previous work on transparent support and on a new mathematical formalism which generalizes the Kubelka-Munk theory. The printed paper is modelized by means of three matrices: an interface correction matrix, a matrix exponential modelizing the layer which contains the fluorescent ink, and a reflection matrix caracterising the substrate. The interface correction matrix allows to take multiple reflections into account by operating the Saunderson correction. These matrices are related to physical properties of ink and paper which must be measured: the transmittance spectra, the quantum yields, the absorption bands and the emission spectra of the fluorescent inks, and the reflection properties of the paper. Our new model can predict the reflection spectra of uniform samples for different ink concentrations and under different illuminants. It is applied successfully to predict the spectra of real samples with an average prediction improvement of about ΔE = 17 in comparison with Beer's law.
Near maximum likelihood soft-decision decoding of a particular class of rate-1/2 systematic linear block codes (2011)

Presented is a soft-decision decoding algorithm for a particular class of rate-1/2 systematic linear block codes. The proposed algorithm performs successive re-encoding of both the data and parity bits, to produce a list of codewords among which the most likely candidate is chosen. Simulation results show that close to optimal performance can be obtained at reasonable complexity. They validate the potential of the proposed algorithm as a practical approach for soft-decision decoding.
Analysis of Hydrazine-Ammonia Mixtures. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of Hydrazine-Ammonia Mixtures.B. E. Knox and E. T. McHaleCite this: Anal. Chem. 1966, 38, 3, 487–488Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/ac60235a001https://doi.org/10.1021/ac60235a001research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts