gebhart/patrepeval huggingface dataset:
Load balancing problems for multiclass jobs in distributed/parallel computer systems (1998)

Load balancing problems for multiclass jobs in distributed/parallel computer systems with general network configurations are considered. We construct a general model of such a distributed/parallel computer system. The system consists of heterogeneous host computers/processors (nodes) which are interconnected by a generally configured communication/interconnection network wherein there are several classes of jobs, each of which has its distinct delay function at each host and each communication link. This model is used to formulate the multiclass job load balancing problem as a nonlinear optimization problem in which the goal is to minimize the mean response time of a job. A number of simple and intuitive theoretical results on the solution of the optimization problem are derived. On the basis of these results, we propose an effective load balancing algorithm for balancing the load over an entire distributed/parallel system. The proposed algorithm has two attractive features. One is that the algorithm can be implemented in a decentralized fashion. Another feature is simple and straightforward structure. Models of nodes, communication networks, and a numerical example are illustrated. The proposed algorithm is compared with a well-known standard steepest-descent algorithm, the FD algorithm. By using numerical experiments, we show that the proposed algorithm has much faster convergence in terms of computational time than the FD algorithm.
Structure and stability of Co(II)-complexes formed by wild-type and metal-ligand substitution mutants of T4 gene 32 protein (1996)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
The Effects of Tranilast on Granulation Hyperplasia after Phonosurgery. (2001)

音声外科手術後に生じる肉芽形成や瘢痕形成は,術後音声を大きく左右する。そこで，肥厚性瘢痕治療薬であるトラニラストの局所投与による肉芽組織形成抑制効果を実験的に検討した。方法：0.5％カラゲニン誘発刺激による肉芽組織およびイヌ声帯新鮮創に対して，2.0％トラニラストおよびリポソーム封入2％トラニラストを局所投与し検討した。結果：2％トラニラストに比較して，リポソーム封入2％トラニラストは組織内に長く止まり，肉芽組織の増生抑制効果をより促進した。また，イヌ声帯新鮮創に対して局所投与した結果，術後に良好な声帯振動が得られた。結論：トラニラストの局所投与により，肉芽組織の増殖抑制効果が認められ，さらにリポソームに封入した形態にして投与することにより組織内濃度が維持され，肉芽組織の増生抑制効果がより増強された。
A simple method for the isolation of adrenal chromaffin granules on a large scale (1967)

Highly purified chromaffin granules can be obtained from homogenates of either ox, pig, horse or rat adrenal medullae by ultracentrifugation of the large-granule fraction layered on 1.6m-sucrose solution, by using angle-head rotors. The chromaffin granules are obtained as a pink sediment that is only slightly contaminated by mitochondria and lysosomes.
Light localization induced enhancement of third order nonlinearities in a GaAs photonic crystal waveguide (2009)

Nonlinear propagation experiments in GaAs photonic crystal waveguides (PCW) were performed, which exhibit a large enhancement of third order nonlinearities, due to light propagation in a slow mode regime, such as two-photon absorption (TPA), optical Kerr effect and refractive index changes due to free-carriers generated by TPA. A theoretical model has been established that shows a very good quantitative agreement with experimental data and demonstrates the important role that the group velocity plays. These observations give a strong insight into the use of PCWs for optical switching devices.
Injectable magnetic liposomes as a novel carrier of recombinant human BMP‐2 for bone formation in a rat bone‐defect model (2003)

Small-sized magnetic liposomes with incorporated recombinant human bone morphogenetic protein-2 (rhBMP-2) were prepared, and the efficiency for bone formation after topical injection was evaluated in a rat bone-defect model. A critical-sized segmental bone defect was created in the mid-part of the femoral shaft, and a permanent magnet was attached. Topical injection onto the defects was performed with different liposomal preparations (nonmagnetic and magnetic liposomes) using different treatment modalities (different doses and different treatment timing of rhBMP-2). Weekly evaluations were made radiographically and microcomputed tomographically, histologically, and/or by mechanical testing at 9 weeks after surgery. A single topical application of magnetic liposomes with an appropriate amount of rhBMP-2 (approximately 3 microg) incorporated under magnetic induction immediately after surgery was effective for new bone formation. The combined treatment of topical magnetic rhBMP-2 liposomes and magnetic implantation at the injury site was effective for the treatment of bone defects. This injectable carrier for BMP is expected to have many advantages over solid carriers because it can be prepared easily and can be less invasively applied to the injured site at any time after surgery.
Human brain cancer studied by resonance Raman spectroscopy (2012)

The resonance Raman (RR) spectra of six types of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro. Forty-three RR spectra from seven subjects are investigated. The spectral peaks from malignant meningioma, stage III (cancer), benign meningioma (benign), normal meningeal tissues (normal), glioblastoma multiforme grade IV (cancer), acoustic neuroma (benign), and pituitary adenoma (benign) are analyzed. Using a 532-nm excitation, the resonance-enhanced peak at 1548 cm-1 (amide II) is observed in all of the tissue specimens, but is not observed in the spectra collected using the nonresonance Raman system. An increase in the intensity ratio of 1587 to 1605 cm-1 is observed in the RR spectra collected from meningeal cancer tissue as compared with the spectra collected from the benign and normal meningeal tissue. The peak around 1732 cm-1 attributed to fatty acids (lipids) are diminished in the spectra collected from the meningeal cancer tumors as compared with the spectra from normal and benign tissues. The characteristic band of spectral peaks observed between 2800 and 3100 cm-1 are attributed to the vibrations of methyl (─CH3) and methylene (─CH2─) groups. The ratio of the intensities of the spectral peaks of 2935 to 2880 cm-1 from the meningeal cancer tissues is found to be lower in comparison with that of the spectral peaks from normal, and benign tissues, which may be used as a distinct marker for distinguishing cancerous tissues from normal meningeal tissues. The statistical methods of principal component analysis and the support vector machine are used to analyze the RR spectral data collected from meningeal tissues, yielding a diagnostic sensitivity of 90.9% and specificity of 100% when two principal components are used.
A converged hardware solution for FFT, DCT and Walsh transform (2003)

In this paper, we are interested in developing a programmable baseband processor for multiple radio standards, including the wireless LAN standards 802.11a and 802.11b. 802.11a is based on OFDM and uses a 64-point FFT. Demodulation of the complementary code keying (CCK) used in 802.11b includes the computation of a modified Walsh transform. Similarities have been found between the radix-4 FFT and the fast Walsh transform (FWT) and this has enabled the design of a converged FFT and FWT processor. With small modifications this processor can also be used for calculating the discrete cosine transform (DCT). A converged FFT/FWT/DCT processor was designed and synthesized in a 0.13/spl mu/m process. Results indicate that the hardware can run at 385 MHz, which means a 64-point FFT/DCT is calculated in 140 ns and a FWT for 802.11b 11Mb/s CCK in 47 ns. The area including memory is 0.40 mm/sup 2/.
Radiopharmaceuticals II: proceedings of the 2nd international symposium on radiopharmaceuticals (1980)

Papers from the 1979 international symposium, including a keynote address by former AEC Chairperson Dixy Lee Ray and a panel discussion entitled International Regulatory Affairs Relating to Radiopharmaceuticals are presented. Chapters cover such topics as quality control, organic and inorganic radiopharmaceuticals, functional imaging, RIA, pharmacokinetics, and various body systems.
Integrated Electrochemical Gluconic Acid Biosensor Based on Self-Assembled Monolayer-Modified Gold Electrodes. Application to the Analysis of Gluconic Acid in Musts and Wines (2007)

An integrated amperometric gluconic acid biosensor constructed using a gold electrode (AuE) modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA) on which gluconate dehydrogenase (GADH, 0.84 U) and the mediator tetrathiafulvalene (TTF, 1.5 micromol) were coimmobilized by covering the electrode surface with a dialysis membrane is reported. The working conditions selected were Eapp=+0.15 V and 25+/-1 degrees C. The useful lifetime of one single TTF-GADH-MPA-AuE was surprisingly long. After 53 days of continuous use, the biosensor exhibited 86% of the original sensitivity. A linear calibration plot was obtained for gluconic acid over the 6.0x10(-7) to 2.0x10(-5) M concentration range, with a limit of detection of 1.9x10(-7) M. The effect of potential interferents (glucose, fructose, galactose, arabinose, and tartaric, citric, malic, ascorbic, gallic, and caffeic acids) on the biosensor response was evaluated. The behavior of the biosensor in a flow-injection system in connection with amperometric detection was tested. The analytical usefulness of the biosensor was evaluated by determining gluconic acid in wine and must samples, and the results obtained were validated by comparison with those provided by using a commercial enzyme test kit.
Reliability of the Q-Sort Inventory of Parenting Behaviors (1989)

Test-retest reliability on the Q-Sort Inventory of Parenting Behaviors was obtained by using a sample of 30 mothers of 3-year-old children. The inventory consists of 72 statements, each of which describes a different parenting behavior and utilizes a forced-choice format. Mothers independently sorted the statements into nine ordered categories along a continuum from "most like me" to "least like me" and repeated the sort 2 weeks later. Analysis of variance and Pearson product-moment correlations indicated that the within-subject correlation between first and second sorts was .72. Of this total variability, .37 was common to all mothers. This variability was probably engendered by variance in social desirability of the items. Of the variance, 35% was due to reliable differences among respondents in the profile of item responses.
The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update (2013)

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are constantly damaged by noxious agents. Eukaryotic cells have developed efficient mechanisms to deal with this assault. The process of DNA repair in mitochondria, initially believed nonexistent, has now evolved into a mature area of research. In recent years, it has become increasingly appreciated that mitochondria possess many of the same DNA repair pathways that the nucleus does. Moreover, a unique pathway that is enabled by high redundancy of the mitochondrial DNA and allows for the disposal of damaged DNA molecules operates in this organelle. In this review, we attempt to present a unified view of our current understanding of the process of DNA repair in mitochondria with an emphasis on issues that appear controversial.
Role of Kupffer cells in the pathogenesis of liver disease (2006)

Kupffer cells, the resident liver macrophages have long been considered as mostly scavenger cells responsible for removing particulate material from the portal circulation. However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, intrahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver fibrosis. There is accumulating evidence, reviewed in this paper, suggesting that Kupffer cells may act both as effector cells in the destruction of hepatocytes by producing harmful soluble mediators as well as antigen presenting cells during viral infections of the liver. Moreover they may represent a significant source of chemoattractant molecules for cytotoxic CD8 and regulatory T cells. Their role in fibrosis is well established as they are one of the main sources of TGFbeta1 production, which leads to the transformation of stellate cells into myofibroblasts. Whether all these variable functions in the liver are mediated by different Kupffer cell subpopulations remains to be evaluated. In this review we propose a model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease.
Design analysis of a high <i>T</i> <i>c</i> superconducting microbolometer (1989)

We propose an antenna-coupled microbolometer based on the resistive transition of a high Tc superconducting film as a detector for far infrared and millimeter waves. Such microbolometers can be mechanically stronger, more easily fabricated, and much faster than conventional bolometric infrared detectors. A design analysis shows that a noise equivalent power of 2.5×10−12 W Hz−1/2 is achievable for modulation frequencies up to 10 kHz. The superconducting film must be of high quality with narrow resistive transition and low 1/f noise.
COBOL (1999)

article Free Access Share on COBOL: is it dying — or thriving? Author: Robert L. Glass Software Engineering Institute, Seattle University Software Engineering Institute, Seattle UniversityView Profile Authors Info & Claims ACM SIGMIS Database: the DATABASE for Advances in Information SystemsVolume 30Issue 1Winter 1999 pp 15–18https://doi.org/10.1145/342251.342256Online:01 January 1999Publication History 1citation141DownloadsMetricsTotal Citations1Total Downloads141Last 12 Months9Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ECC-on-SIMM test challenges (1994)

The typical personal computer of today is used more and more to perform functions and run application programs that are critical to a business's success. One of the biggest problems that inhibits productivity in this environment Is the effect of a lock-up, crash or parity error caused by cosmic-ray radiation-induced soft errors in the DRAM chips. IBM has announced a family of plug-compatible, retrofittable SIMMs with built-in ECC to provide a solution to this problem. This paper addresses the challenges associated with the full functional test of a SIMM with on-board ECC using a very test-unfriendly industry-standard memory module interface.
<scp>d</scp>‐Amino acids in the brain:<scp>d</scp>‐serine in neurotransmission and neurodegeneration (2008)

The mammalian brain contains unusually high levels of D-serine, a D-amino acid previously thought to be restricted to some bacteria and insects. In the last few years, studies from several groups have demonstrated that D-serine is a physiological co-agonist of the N-methyl D-aspartate (NMDA) type of glutamate receptor -- a key excitatory neurotransmitter receptor in the brain. D-Serine binds with high affinity to a co-agonist site at the NMDA receptors and, along with glutamate, mediates several important physiological and pathological processes, including NMDA receptor transmission, synaptic plasticity and neurotoxicity. In recent years, biosynthetic, degradative and release pathways for D-serine have been identified, indicating that D-serine may function as a transmitter. At first, D-serine was described in astrocytes, a class of glial cells that ensheathes neurons and release several transmitters that modulate neurotransmission. This led to the notion that D-serine is a glia-derived transmitter (or gliotransmitter). However, recent data indicate that serine racemase, the D-serine biosynthetic enzyme, is widely expressed in neurons of the brain, suggesting that D-serine also has a neuronal origin. We now review these findings, focusing on recent questions regarding the roles of glia versus neurons in d-serine signaling.
Determination and pharmacokinetic study of tussilagone in rat plasma by RP‐HPLC method (2008)

A simple and rapid high-performance liquid chromatographic method was used to study the pharmacokinetics of tussilagone, one of the main bioactive constituents in the flower buds of Tussilago farfara L. of traditional Chinese medicines, in rat plasma. Plasma was deproteinized by ethyl acetate for sample clean-up. The drugs were separated on a Dikma Diamonsil C18 column (4.6 x 250 mm, 5.0 microm), and detected by UV absorption at 220 nm. Methanol-water (75:25, v/v) was used as the mobile phase. It was applied to the pharmacokinetic study of tussilagone in rats after a dose of 5 mg/kg by intravenous administration and a dose of 200 mg/kg by intragastrical administration. A biphasic phenomenon with a rapid distribution followed by a slower elimination phase was observed from the plasma concentration-time curve by intravenous administration, while the plasma concentration-time curve of tussilagone conformed to a one-compartment model by intragastrical administration. The absolute bioavailability of tussilagone is about 1.31%.
The structure and function of membrane glycoproteins (1984)

~y an eight-residue coil segment. The model is used to predict the folding kinetics of apomyoglobin and of the lambda-phage repressor operator-binding domain.
Correlation-based Feature Selection for Discrete and Numeric Class Machine Learning (2000)

Algorithms for feature selection fall into two broad categories: wrappers use the learning algorithm itself to evaluate the usefulness of features, while lters evaluate features according to heuristics based on general characteristics of the data. For application to large databases, lters have proven to be more practical than wrappers because they are much faster. However, most existing lter algorithms only work with discrete classi cation problems. This paper describes a fast, correlation-based lter algorithm that can be applied to continuous and discrete problems. Experiments using the new method as a preprocessing step for naive Bayes, instance-based learning, decision trees, locally weighted regression, and model trees show it to be an e ective feature selector|it reduces the data in dimensionality by more than sixty percent in most cases without negatively a ecting accuracy. Also, decision and model trees built from the pre-processed data are often signi cantly smaller. 1 1
A face-to-face chip stacking 7kV RMS digital isolator for automotive and industrial motor drive applications (2014)

A face-to-face chip stacking isolator structure, which makes it easy to enhance the insulation voltage, is proposed. Transmitter (Tx) and receiver (Rx) chips, each of which has a coil, are stacked and communicate through a magnetic coupling of the coils. The die attach film sandwiched by the two chips not only bonds the chips but also enhances the insulation voltage by taking advantage of its thickness. With test chips, the breakdown voltage of 7 kV RMS is demonstrated and >20-year lifetime with a working voltage of 1.5 kV is estimated by extrapolation of time-dependent dielectric breakdown results.
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism. (1981)

An expressed gene for gamma 1 chain of MC 101 myeloma was cloned from a phage library containing partial EcoRI digests of MC 101 DNA. The cloned DNA was analyzed by restriction enzyme cleavage, Southern blot hybridization, R-loop formation, and nucleotide sequence determination. The results indicate that the expressed gamma 1 chain gene comprises at least four germline DNA segments, namely a variable-region gene, a segment of the 5' flanking region of the mu chain gene (containing J regions), a segment of the 5' flanking region of the alpha chain gene, and the gamma 1 chain gene with its flanking regions. The presence of the alpha chain gene-flanking switch (S) region (S alpha region) at the 5' side of the gamma 1 chain gene-flanking region (S gamma 1 region) indicates that the heavy chain class switch may not be mediated by stepwise linear deletion along the order of the heavy chain constant-region genes (5'-mu-gamma 3-gamma 1-gamma 2b-gamma 2a-alpha-3'). We propose a siter-chromatid exchange model that explains class switch-associated deletion of heavy chain genes by unequal crossing-over events between sister chromatids.
Do Psychosocial Variables Predict Weight Loss or Mental Health after Obesity Surgery? A Systematic Review (2004)

Personality traits have no predictive value for the postoperative course of weight or mental state. Apart from serious psychiatric disorders including personality disorders, psychiatric comorbidity seems to be of more predictive value for mental and physical well-being as two essential aspects of quality of life than for weight loss postsurgery. However, depressive and anxiety symptoms as correlates of psychological stress with regard to obesity seem to be positive predictors of weight loss postsurgery. The severity of the symptoms or the disorder is more relevant for the outcome of obesity surgery than the specificity of the symptoms. It is also not solely the consumption of distinct "forbidden" foods, such as sweets or soft drinks, but rather a general hypercaloric eating behavior, either as an expression of the patient's inadequate compliance or a dysregulation in energy balance, which is associated with a poor weight loss postsurgery.
Cryptographically secure radios based on directional modulation (2014)

Directional modulation (DM) can be regarded as a new frontier in physical layer communication security. This new technique uses an antenna array as a spatial encryption system which partitions the surrounding space into regions where the transmission is either perfectly intelligible or intentionally obfuscated. Still, energy and spectral efficiencies of current DM systems as well as their cryptographic robustness lag behind the modern performance standards in cryptography and radio-communication. This contribution proposes a generalization of the DM concept which overcomes the limitations of its initial formulation by making it both compatible with state-of-art digital modulations and cryptographically secure. Numerical analyses as well as real-world, high bit-rate implementation results are presented in support of the proposed approach.
A Structure‐Based Virtual Screening Approach toward the Discovery of Histone Deacetylase Inhibitors: Identification of Promising Zinc‐Chelating Groups (2010)

The inhibitors of histone deacetylases (HDACs) have drawn a great deal of attention due to their promising potential as small-molecule therapeutics for the treatment of cancer. By means of virtual screening with docking simulations under consideration of the effects of ligand solvation, we were able to identify six novel HDAC inhibitors with IC(50) values ranging from 1 to 100 muM. These newly identified inhibitors are structurally diverse and have various chelating groups for the active site zinc ion, including N-[1,3,4]thiadiazol-2-yl sulfonamide, N-thiazol-2-yl sulfonamide, and hydroxamic acid moieties. The former two groups are included in many drugs in current clinical use and have not yet been reported as HDAC inhibitors. Therefore, they can be considered as new inhibitor scaffolds for the development of anticancer drugs by structure-activity relationship studies to improve the inhibitory activities against HDACs. Interactions with the HDAC1 active site residues responsible for stabilizing these new inhibitors are addressed in detail.