gebhart/patrepeval huggingface dataset:
Relative configuration of thioridazine enantiomers (1991)

Abstract The relative configuration of the enantiomers of thioridazine was defined to explore the stereochemistry associated with the selective binding of (−)‐thioridazine to dopamine D‐1 receptors and (+)‐thioridazine to D‐2 receptors. Using a seven‐step stereoconservative synthesis, (−)‐(S)‐2‐piperidinecarboxylic acid was converted to (−)‐(S*)‐2‐(2‐chloroethyl)‐1‐methylpiperidine, a literature (−)‐thioridazine synthetic precursor. Accordingly, (−)‐ and (+)‐thioridazine are the (S)‐ and (R)‐enantiomers, respectively.
Dynamic holographic phase gratings in multiple-quantum-well asymmetric Fabry–Perot reflection modulators (1994)

Dynamic holographic pi-phase gratings can be written in a multiple-quantum-well asymmetric Fabry-Perot reflection modulator by spatial modulation of the quantum-confined exciton absorption. Operating near the Fabry-Perot resonance, the phase grating quenches the zero-order reflection and enhances the first-order diffraction efficiency. The diffraction efficiency of these structures as diffractive optics elements is not sensitive to the contrast ratio, which eases the constraints for device fabrication. Numerical simulations for multiple-quantum-well structures are presented that fully include refractive-index changes in response to a spatial modulation of the exciton absorption, which can be caused by any of several techniques, including free-carrier gratings, absorption bleaching, electro-optic effects, and photorefractive effects.
A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol (2001)

Resveratrol, a phytoalexin found in grapes and wines, has been reported to exhibit a wide range of pharmacological properties and is believed to play a role in the prevention of human cardiovascular disease (the so-called 'French paradox'). This molecule may also play a major role in both cancer prevention and therapy. In this review article we summarize the recent advances that have provided new insights into the molecular mechanisms underlying the promising properties of resveratrol. These include cyclooxygenase, nitric oxide synthase and cytochrome P450 inhibition, as well as cell cycle effects, apoptosis modulation and hormonal activity.
Parallel SOR Iterative Algorithms and Performance Evaluation On a Linux Cluster (2005)

Abstract: The successive over-relaxation (SOR) how to quickly verify and generate a iterative method is an important solver for linear multicoloring ordering according to the given systems. In this paper, a parallel algorithm for the structure of a matrix or a grid. However, the red-black SOR method with domain decomposition is multi-color SOR method is parallel only within investigated. The parallel SOR algorithm is designed the same color. For some problems such as two by combining the traditional red-black SOR and row block domain decomposition technique, which reduces the communication cost and simplifies the parallel Poisson equations, the Red-Black two-color SOR implementation. Two other iterative methods, Jacobi method is preferred. Yanheh [4] showed that the and Gauss-Seidel(G-S), are also implemented in Red-Black SOR method is more efficient and parallel for comparison. The three parallel iterative smoother than the sequential SOR method. Xie algorithm are implemented in C and MPI (Message proposed an efficient parallel SOR method Passing Interface) for solving the Dirichlet problem (PSOR) using domain decomposition and on a Linux cluster with eight dual processor 2.6ghz 32 interprocessor data communication techniques bit Intel Xeons, totaling 16 processors. The [5]. It is shown that PSOR is just the SOR performances of the three algorithms are evaluated in method applied to a reordered linear system, soterms of speedup and efficiency. that the theory of SOR can also be applied to the
Advancing personalized cancer therapy by detection and characterization of circulating carcinoma cells (2010)

Early dissemination, blood circulation, or homing of single tumor cells in bone marrow and other organs is usually undetectable at primary diagnosis, even by high resolution imaging technologies. However, ultrasensitive approaches now enable the detection of "occult" tumor cells. Many researchers are currently focusing on circulating tumor cells (CTC) in peripheral blood, and several publications have described associations of CTC in patients with metastatic cancer and worse prognosis. However, evidence has emerged that the currently used detection methods lack sensitivity or specificity to track all CTC, especially those that have lost characteristic epithelial features. Therefore, new developments in this field are of utmost interest and will be reviewed here. Moreover, molecular CTC analysis will provide insights into the selection of tumor cells and resistance mechanisms in patients undergoing systemic therapies. This information might support assessing individual prognosis, stratifying patients at risk to systemic therapies, and monitoring therapeutic efficacy.
Some Characteristics of a New Enzyme “Glycerol Oxidase” (1979)

Journal Article Some Characteristics of a New Enzyme “Glycerol Oxidase” Get access Takayuki Uwajima, Takayuki Uwajima Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Machida-shi, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Hiroko Akita, Hiroko Akita Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Machida-shi, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Kunio Ito, Kunio Ito Pharmaceutical Laboratory, Fuji Factory, Kyowa Hakko Kogyo Co., Ltd., Nagaizumi-cho, Shizuoka-ken Search for other works by this author on: Oxford Academic Google Scholar Akira Mihara, Akira Mihara Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Machida-shi, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Kazuo Aisaka, Kazuo Aisaka Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Machida-shi, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Osamu Terada Osamu Terada Tokyo Research Laboratory, Kyowa Hakko Kogyo Co. Ltd., Machida-shi, Tokyo Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 43, Issue 12, 1 December 1979, Pages 2633–2634, https://doi.org/10.1080/00021369.1979.10863875 Published: 01 December 1979 Article history Received: 05 September 1979 Published: 01 December 1979
Unrealistic beliefs of clinical couples: Their relationship to expectations, goals and satisfaction (1981)

Abstract Forty-seven marital therapy couples completed inventories measuring unrealistic beliefs about self and unrealistic beliefs about marital relationships. In addition, they completed questionnaire measures of their expectations and goals for therapy and their levels of marital satisfaction. As hypothesized, the clients' unrealistic beliefs, particularly those regarding relationships, were negatively associated with their estimated chance for improvement in therapy, desire to improve rather than terminate the relationship, preference for marital versus individually oriented treatment, and overall marital satisfaction. These results are consistent with the theoretical rationale for cognitive therapy with clinical couples and suggest specific targets for intervention in this process. Directions for future research are discussed.
Damage Detection Testing on a Helicopter Flexbeam (2001)

The main and tail rotor systems of a helicopter must be maintained in a damage-free condition to ensure the safety of the helicopter. The components of the rotor system require regular maintenance and inspection, and some of the components are difficult to inspect. Accordingly, an integrated sensor system that continuously monitors the structural integrity of the rotor system is needed to assure the safety of flight and reduce the cost of maintenance of the rotor system. This smart monitoring system could also provide immediate information on the dynamic loading in the rotor system. This information could define the performance limit of the helicopter based on the condition of the rotor system. The operator will then be able to adjust the flight condition and prevent damage from occurring or propagating. The challenges in designing this monitoring system are related to the operating conditions of the helicopter. These include significant aerodynamic and external damping in bending and torsion modes, moderate nonlinearities in the system, large dynamic loads, and difficulty in actuating pure interrogation signals in the airborne condition. In this paper, piezoceramic sensors and actuators and different techniques for damage detection that use symmetry properties of the structure and no structural model are tested in a static condition for health monitoring of a helicopter flexbeam. Testing under dynamic loading is needed as the next step in the development of the smart sensor system.
Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays (2011)

Future studies will focus on examining the significance of these age-related changes in circulating cytokines and other biological markers and their potential contribution to the development of different age-associated diseases.
Mycobacterium bovis BCG-Induced Granuloma Formation Depends on Gamma Interferon and CD40 Ligand but Does Not Require CD28 (2001)

Progressive granuloma formation is a hallmark of chronic mycobacterial infection. Granulomas are localized, protective inflammatory reactions initiated by CD4+ T cells, which contribute to control of bacterial growth and blockade of bacterial dissemination. In order to understand the costimulatory requirements that allow CD4+ T cells to directly or indirectly induce granulomas, we studied granuloma formation after 6 weeks in Mycobacterium bovis BCG-infected CD28- and CD40 ligand (CD40L)-deficient mice and compared it to granuloma formation in infected wild-type inbred mice and infected cytokine-deficient mice. We characterized granulomas morphologically in liver sections, analyzed granuloma infiltrating cells by flow cytometry, and measured cytokine production by cultured granuloma cells. CD28-deficient mice have no defect at the local inflammatory site, inasmuch as they form protective granulomas and control bacterial growth. However, there are fewer activated T cells in the spleen compared to infected wild-type animals, and quantitative differences in the cellular composition of the granuloma are observed by flow cytometry. In CD40L-deficient mice, the granuloma phenotype is very similar to the phenotype in gamma interferon (IFN-gamma)-deficient mice. Both IFN-gamma-deficient and CD40L-deficient mice form granulomas which prevent bacterial dissemination, but control of bacterial growth is significantly impaired. The relative proportion of CD4+ T cells in granulomas from both CD28(-/-) and CD40L(-/-) mice is significantly decreased compared with wild-type animals. Both models demonstrate that the phenotype and activation stage of systemic T cells do not always correlate with the phenotype and activation stage of the localized granulomatous response.
Fabry-Perot Prefilter for Raman Spectroscopy (1979)

Current interest in low frequency excitations in polymers and biopolymers has raised anew the long standing problem of stray light rejection in Raman spectrometers. We report here progress in an attempt to use a Fabry-Perot (FP) interferometer in tandem with a Spex double monochromator for high contrast. This combination has produced a useful improvement in contrast over the Spex alone, by a factor of about 200, while maintaining the throughput, about 50% of the Spex alone. The system was not optimal by any means and we describe results from an apparatus which is now undergoing considerable development.
Electrogenerated chemiluminescence. XIX. Preparation and chemiluminescence of 5,12-dibromo-5,12-dihydro-5,6,11,12-tetraphenylnaphthacene (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrogenerated chemiluminescence. XIX. Preparation and chemiluminescence of 5,12-dibromo-5,12-dihydro-5,6,11,12-tetraphenylnaphthaceneCsaba P. Keszthelyi and Allen J. BardCite this: J. Org. Chem. 1974, 39, 19, 2936–2937Publication Date (Print):September 1, 1974Publication History Published online1 May 2002Published inissue 1 September 1974https://pubs.acs.org/doi/10.1021/jo00933a029https://doi.org/10.1021/jo00933a029research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spatial-based skin detection using discriminative skin-presence features (2013)

In this paper we propose a new method for skin detection in color images which consists in spatial analysis using the introduced texture-based discriminative skin-presence features. Color-based skin detection has been widely explored and many skin color modeling techniques were developed so far. However, efficacy of the pixel-wise classification is limited due to an overlap between the skin and non-skin pixels reported in many color spaces. To increase the discriminating power of the skin classification schemes, textural and spatial features are often exploited for skin modeling. Our contribution lies in using the proposed discriminative feature space as a domain for spatial analysis of skin pixels. Contrary to existing approaches, we extract the textural features from the skin probability maps rather than from the luminance channel. Presented experimental study confirms that the proposed method outperforms alternative skin detection techniques, which also involve analysis of textural and spatial features.
La conciencia de la muerte como conciencia de la vida (2005)

La muerte humana es un asunto muy esquivo, no solo por el temor que suscita sino por su acontecer en una zona mas alla de toda experiencia comunicable, y a la vez representa una instancia personalmente decisiva ante la cual no cabe la indiferencia. La sombra que sobre ella se cierne no impide, sin embargo, analizar la condicion determinada por la existencia de un limite en el tiempo y la conciencia de este limite.
Alkylated steroids. Part 1. 16α-Substituted 17α-methylpregnanes (1976)

The sequential reaction of 3β-acetoxypregna-5,16-dien-20-one (1) with methylmagnesium bromide and then methyl iodide has been examined in detail. The major product (85%) was 3β-hydroxy-16α,17α-dimethylpregn-5-en-20-one (2). Other products identified were 3β-hydroxy-16α-methylpregn-5-en-20-one (4); the 21-methyl derivatives [(5) and (10)] of (2) and (4); the 21-(1-hydroxy-1-methylethyl) derivative (11) of (2); and a trace of the 21,21-dimethyl derivative (12) of (2). The scope of the reaction with regard to the range of substituents that can be introduced at positions 16 and 17 has been established by preparing a series of 16α-substituted 17α-methylpregnenolones with a variety of alkyl, aryl, and aralkyl groups. Some of these have been converted into the corresponding 16α,17α-disubstituted progesterones.
Tackling obesity: we need a hand from Nanny (2004)

The House of Commons Health Committee has been extremely busy recently, producing two explosive reports in as many months. The report on elder abuse published in April will, it is hoped, lead to significant changes in the training of health and social care professionals, and a far greater awareness of the prevalence of abuse. Few will argue with its recommendations.
Constellation shape as a robust signature for digital modulation recognition (2003)

This work reports on a new digital modulation recognition algorithm in an AWGN channel and in the presence of carrier recovery errors. The proposed classification technique uses the signal constellation shape as a stable modulation signature. The recovered constellations are modeled by binomial nonhomogenous spatial random fields and are used in an ML classifier. We experimentally show that shape as a global signature exhibits considerable stability in high noise, weakly synchronous environments. Experimental results are shown for various modulation standards including V.29, V.29 fallback, 8-PSK and 16-QAM.
TAILOR: Transgene Activation and Inactivation Using Lox and Rox in Zebrafish (2013)

The ability to achieve precisely tailored activation and inactivation of gene expression represents a critical utility for vertebrate model organisms. In this regard, Cre and other site-specific DNA recombinases have come to play a central role in achieving temporally regulated and cell type-specific genetic manipulation. In zebrafish, both Cre and Flp recombinases have been applied for inducible activation, inactivation and inversion of inserted genomic elements. Here we describe the addition of Dre, a heterospecific Cre-related site-specific recombinase, to the zebrafish genomic toolbox. Combining Dre-based recombination in zebrafish with established Cre/lox technology, we have established an effective strategy for transgene activation and inactivation using lox and rox (TAILOR). Using stable transgenic lines expressing tamoxifen-inducible CreER(T2) and RU486-inducible DrePR fusions, we demonstrate that Cre and Dre retain non-overlapping specificities for their respective lox and rox target sites in larval zebrafish, and that their combinatorial and sequential activation can achieve precisely timed transgene activation and inactivation. In addition to TAILOR, the successful application of Dre/rox technology in zebrafish will facilitate a variety of additional downstream genetic applications, including sequential lineage labeling, complex genomic rearrangements and the precise temporal and spatial control of gene expression through the intersection of partially overlapping promoter activities.
Synthesis, Spectral Characterization and Anticancer Activity of New 2,3,6- Substituted Quinazolin-4(3H)-one Derivatives (2015)

A series of ten new 2,3,6-substituted quinazolin-4(3H)-one derivatives (10a-j) were prepared from anthranilic acid (1) in a simple and economical path in a series of reactions and screened for their anticancer activity against pancreatic cancer cell line (PANC-1) using MTT assay. The results reveal that at concentration 100 µM/L, compounds 10b, 10f, 10g and 10h exhibited potential anticancer activity by inhibiting the growth of PANC-1 cells by >75% and remaining compounds showed moderate anticancer activity. The structural characterization of the synthesized compounds was elucidated by 1H & 13C NMR, LC-MS, FT-IR and elemental analysis. As potential anti-tumor agents, these new derivatives show promise for further research. Keywords: Anthranilic acid, Pd catalyst, piperazine, quinazolin-4(3H)-ones, anticancer activity, pancreatic cancer cell line-1 (PANC-1).
Fibroblast-to-myofibroblast transition in bronchial asthma (2018)

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling plays a significant role. This phenomenon is related to enhanced proliferation of airway smooth muscle cells, elevated extracellular matrix protein secretion and an increased number of myofibroblasts. Phenotypic fibroblast-to-myofibroblast transition represents one of the primary mechanisms by which myofibroblasts arise in fibrotic lung tissue. Fibroblast-to-myofibroblast transition requires a combination of several types of factors, the most important of which are divided into humoural and mechanical factors, as well as certain extracellular matrix proteins. Despite intensive research on the nature of this process, its underlying mechanisms during bronchial airway wall remodelling in asthma are not yet fully clarified. This review focuses on what is known about the nature of fibroblast-to-myofibroblast transition in asthma. We aim to consider possible mechanisms and conditions that may play an important role in fibroblast-to-myofibroblast transition but have not yet been discussed in this context. Recent studies have shown that some inherent and previously undescribed features of fibroblasts can also play a significant role in fibroblast-to-myofibroblast transition. Differences observed between asthmatic and non-asthmatic bronchial fibroblasts (e.g., response to transforming growth factor β, cell shape, elasticity, and protein expression profile) may have a crucial influence on this phenomenon. An accurate understanding and recognition of all factors affecting fibroblast-to-myofibroblast transition might provide an opportunity to discover efficient methods of counteracting this phenomenon.
AntColony Algorithm Based on Optimization of Potential Field Method for Path Planning (2014)

To realize path planning in complicated environments,a new potential field optimal ant colony algorithm for path planning was presented.To further quicken the convergence speed of AC,the path planning results of potential field method were taken as the prior knowledge,and the original reached grids were initialized by neighborhood pheromone.The potential field guided weight was constructed to change transition probability as well,thus it can be active over the entire period of path searching,and can get rid of blindness.Simulation results indicate that the proposed algorithm(APF-AC)is characterized by high convergence speed,short planning path and self-adaptive.
Paramecium tetraurelia Growth Stimulation under Low-Level Chronic Irradiation: Investigations on a Possible Mechanism (1982)

Experiments were carried out to demonstrate the effects of low-level chronic irradiation on Paramecium tetraurelia proliferation. Biological effects were strongly dependent on the bacterial density of culture medium and more exactly on the catalase content of the medium. Significant growth stimulation was found under60 Co chronic irradiation at a dose rate of 2 rad/year when paramecia were grown in a medium containing a high bacterial concentration (2.5× 107 cells/ ml) or supplemented with catalase (300 U/ml). In a medium with a low bacterial density ( $1\times 10^{6} \text{cell}/{\rm ml}$ ) or supplemented with a catalase activity inhibitor, growth stimulation was preceded by a transitory inhibiting effect which could be correlated with extracellularly radioproduced H2 O2. H2 O2 addition appeared to be able to simulate the biological effects of chronic irradiation. A possible mechanism is discussed. We propose that the stimulating effects were the result of intracellular enzymatic sca...
Network Traffic Capture and Storage for IPv6 Network (2006)

Network traffic characteristics in operational network is crucial to network design and operation. As the network bandwidth grows, it's difficult for capturing and storing a detailed record for every packet. In this paper we present a traffic capture system which is implemented at network processor. Both lab experiment and real network operation prove that the capture system is able to process gigabit line rate with a good stability. A data compression method focusing on IPv6 address redundancy and combining flow and packet information together is given for IPv6 trace and alleviates the data storage pressure. Tests show it can compress the storage several fold without losing detailed trace information.