gebhart/patrepeval huggingface dataset:
CCL21 and IFN&#947; Recruit and Activate Tumor Specific T cells in 3D Scaffold Model of Breast Cancer (2014)

Effective elicitation of endogenous immunity is associated with improved prognosis for cancer patients. Clinical evidence in hematological and solid cancers shows that intratumoral injection of immunostimulatory genes primes and augments endogenous T cell responses. The ability of pro-inflammatory chemokines/cytokines to facilitate migration/activation of antigen-presenting cells (APC) and lymphocytes prompted our modeling of intratumoral delivery of a chemokine/cytokine combination for breast cancer treatment. Here, we demonstrate that expression of chemokine ligand 21 (CCL21) and interferon gamma (IFNγ) in tumors improves tumor specific T cell recruitment to tumor and activation in the tumor milieu. IFNγ and CCL21 were delivered into tumor cells via plasmids, and transfected cells were seeded to form spheroids on three-dimensional (3D) chitosan-alginate (CA) scaffolds. Co-expression of CCL21 and IFNγ, as evidenced by qRT-PCR and ELISA, induced increased recruitment, binding, and infiltration of anti-neu (p98) peptide specific T cells into the breast tumors as determined by SEM and immunofluorescence assays. The co-expression promoted recruitment of only p98 T cells, but not naïve T cells, demonstrating an antigen-restricted activation. Furthermore, the co-expression impacted T helper (Th) cell immunity, promoting an increase in secretion of pro-inflammatory Th-associated cytokine, tumor necrosis factor alpha (TNFα), and cytotoxic T lymphocyte (CTL)-associated protease, Granzyme B (GzB). Therefore, 3D CA scaffolds may be a useful breast cancer tumor microenvironment model to evaluate T cell function. Further characterization of CCL21-IFNγ mediated anti-tumor immunity will potentially benefit the development of chemokine/cytokine combination platforms as anti-cancer agents.
Resource monitoring in industrial production with knowledge-based models and rules (2011)

The manufacturing domain currently experiences a significant increase in resource expenses for industrial plants. However, the implementation of systems to monitor the resource consumption in such complex plants requires high investment concerning time and manual effort. Our goal is to describe the plant by means of knowledge-based models and rules to implement a generic, semi-automated monitoring system which can be defined with lower initial effort and which can be adapted quickly to modifications. An advantage of this model-based approach is that the energy and resource consumption of each component in a plant can be associated with a sequence of operations and the effects on the overall system get visible. Another advantage of knowledge-based systems combined with rules is that they offer application independent solutions and flexibility. The paper outlines the state of the art of relevant technologies by describing several approaches, such as existing monitoring systems, rule engines and modeling tools. Furthermore, it describes a representative example that we will use in our further work to evaluate which tools are appropriate for a resource monitoring system.
Myocardial Angiogenesis as a Possible Mechanism for TMLR Efficacy (1997)

Despite advances in the treatment of ischemic heart disease, there still exists a significant number of individuals for whom bypass surgery or angioplasty are not options. Transmyocardial laser revascularization (TMLR) is a promising technology that has already been shown to reduce symptoms in patients with chronic ischemic heart disease that is not amenable to conventional therapies. Although it appears that TMLR can provide symptomatic relief of angina in selected patients, the mechanism by which TMLR is thought to work is unclear. Recently it has been postulated that TMLR induces an angiogenic response and, perhaps, improves local perfusion to ischemic myocardial territories. A brief overview of the biology of myocardial angiogenesis is presented.
Pitting and Crevice Corrosion Potentials of Solar Panel Stainless Steels in Seawater and 0.6M NaCl (1985)

The cyclic potentiokinetic polarization method (scanning rate 10 mV/min), starting at the free corrosion potential and going up to 100 μA/cm2 (surface area), and microscopic observation of the surface were used to evaluate the susceptibility of commercial stainless steels to localized corrosion for their possible application in solar panels. Aerated and deaerated solutions of 0.6M NaCl and seawater at room temperature were used. Considering the average value of the pitting potential obtained in numerous tests, the following stability classification was established for the materials studied: 430&lt;430Nb&lt;304&lt;304L&lt;ELI(C)≤316&lt;ELI(D) The appearance of morphological differences in pits on the same material and the presence of cavernous pits, detectable after light abrasion of the surface or in a cross section of the sample made their quantification and a determination of any definite relation between surface defects (segregations and/or microflaws) and passive film breakdown susceptibility very difficult. Crevice corrosion could occur under free corrosion conditions, especially in the presence of air, and it was detectable from potential oscillations. The crevice potential is not estimated with the same technique used to determine pitting potential because of the strong effect of the critical shield geometry; it is therefore suggested that the redox couple K4Fe(CN)6 − K3Fe(CN)6, in suitable concentration in the system being considered, can give useful indications of this potential. Indeed, the rapid precipitation of Turnbull’s blue physically prevents the repassivation process at the electrode potential established by the redox couple.
Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis. (1990)

Suspensions rich in pancreatic beta cells were transfected by means of electroporation or by using the liposome technique with DNA constructs coding for the B chain of platelet-derived growth factor (PDGF) and the PDGF alpha and beta receptors to induce a mitotic response in this slowly replicating cell type. Transfection with the B-chain construct induced synthesis of the PDGF B-chain homodimer (PDGF-BB) as assessed by the presence of 125I-labeled PDGF-BB competing activity in the conditioned medium of the transfected islet cells. Moreover, islet cells transfected with the PDGF beta-receptor construct exhibited increased immunofluorescence staining with a PDGF beta-receptor antibody. These cells also displayed increased 125I-labeled PDGF-BB binding compared with control transfected cells. Cotransfection with the B-chain construct or the addition of 10% fetal bovine serum or purified PDGF all induced DNA synthesis in islet cells transfected with the PDGF beta-receptor construct. Islet cells transfected with the PDGF alpha-receptor construct did not respond with stimulation of [3H]thymidine incorporation to any of the PDGF isoforms (PDGF-AA, -AB, or -BB). Cotransfection of the PDGF alpha- and beta-receptor constructs resulted in a loss of the DNA synthesis response to PDGF. The beta cells exhibited elevated levels of [3H]inositol trisphosphate after transfection with the B-chain and beta-receptor constructs, indicating activation of phospholipase C. Islet cells transfected with the different receptor constructs exhibited different patterns of tyrosine phosphorylation upon ligand activation. The results demonstrate that pancreatic islet cells can be stimulated to increase DNA synthesis by transfection with the PDGF beta-receptor gene, whereas cotransfection with the alpha-receptor gene may attenuate the growth response.
Cross-Modality Person Re-Identification Based on Dual-Path Multi-Branch Network (2019)

Person re-identification is an important surveillance task of searching and identifying pedestrian across different images or video frames. Despite a significant progress has been made in person re-identification based on RGB image sensors, few work focus on the person re-identification between RGB and infrared images, which is a challenging cross-modality problem and has been widely encountered in a dark environment or at night. In addition to the challenges for the same identity associated with variations in camera viewpoints and person poses, there is a non-negligible shift across different sensor modalities since the visual characteristics from RGB and infrared images are heterogeneous. In this paper, we propose a novel end-to-end dual-path multi-branch network for RGB-infrared cross-modality person re-identification, which introduces the multi-branch deep network architecture. The experimental results obtained with SYSU-MM01 datasets indicate that the proposed method can successfully transfer descriptive visual characteristic between RGB and infrared sensor modality. It can significantly outperform state-of-the-art conventional methods and convolutional neural network methods.
Efficient Microwave-Assisted Solvent-Free Synthesis and Molecular Docking Studies of 2-pyridone derivatives as Anticancer Agents and Evaluation of Cytotoxic Effects (2016)

Introduction: A green protocol will be used to synthesize a novel series of 3-cyano-5- arylazo-pyridones (9a-c) and (10d-i). Methodology: Structures of the new products will be confirmed on the basis of spectroscopic data (FT-IR, 1D, NMR) as well as alternative synthetic routes, anticancer cell-line will be investigated and also molecular docking studies will be applied. Results: The activity against different cancer cell-line will be studied. Compounds with electron withdrawal group showed the highest activities.
Sweeping Gas Membrane Desalination Using Commercial Hydrophobic Hollow Fiber Membranes (2002)

Water shortages affect 88 developing countries that are home to half of the world's population. In these places, 80-90% of all diseases and 30% of all deaths result from poor water quality. Furthermore, over the next 25 years, the number of people affected by severe water shortages is expected to increase fourfold. Low cost methods of purifying freshwater, and desalting seawater are required to contend with this destabilizing trend. Membrane distillation (MD) is an emerging technology for separations that are traditionally accomplished via conventional distillation or reverse osmosis. As applied to desalination, MD involves the transport of water vapor from a saline solution through the pores of a hydrophobic membrane. In sweeping gas MD, a flowing gas stream is used to flush the water vapor from the permeate side of the membrane, thereby maintaining the vapor pressure gradient necessary for mass transfer. Since liquid does not penetrate the hydrophobic membrane, dissolved ions are completely rejected by the membrane. MD has a number of potential advantages over conventional desalination including low temperature and pressure operation, reduced membrane strength requirements, compact size, and 100% rejection of non-volatiles. The present work evaluated the suitability of commercially available technology for sweeping gas membrane desalination. Evaluations were conducted with Celgard Liqui-Cel{reg_sign} Extra-Flow 2.5X8 membrane contactors with X-30 and X-40 hydrophobic hollow fiber membranes. Our results show that sweeping gas membrane desalination systems are capable of producing low total dissolved solids (TDS) water, typically 10 ppm or less, from seawater, using low grade heat. However, there are several barriers that currently prevent sweeping gas MD from being a viable desalination technology. The primary problem is that large air flows are required to achieve significant water yields, and the costs associated with transporting this air are prohibitive. To overcome this barrier, at least two improvements are required. First, new and different contactor geometries are necessary to achieve efficient contact with an extremely low pressure drop. Second, the temperature limits of the membranes must be increased. In the absence of these improvements, sweeping gas MD will not be economically competitive. However, the membranes may still find use in hybrid desalination systems.
Curie Temperature, Biaxial Elastic Modulus, and Thermal Expansion Coefficient of (K,Na)NbO<sub>3</sub>Piezoelectric Thin Films (2009)

We investigated fundamental parameters such as the Curie temperature, biaxial elastic modulus, and thermal expansion coefficient of (K,Na)NbO3 (KNN) films on Pt/Ti/SiO2/Si substrates. From the temperature dependence of the dielectric constant of the KNN films, their Curie temperature was approximately 360 °C; this value was confirmed from critical changes in the lattice parameters of the films and the stress induced in the films at approximately this temperature. By using the optical lever method, the biaxial elastic modulus and thermal expansion coefficient of the KNN films were found to be 92 GPa and 8.0×10-6 (1/°C), respectively. The fundamental properties of the KNN films were similar to those of widely used Pb(Zr,Ti)O3 films, indicating that KNN films are potential candidates for lead-free piezoelectric thin films in micro-electro-mechanical system (MEMS) applications.
Incidence of the Nak(a)‐negative platelet phenotype in African Americans is similar to that of Asians (1996)

The frequency of the GPIV-negative platelet phenotype in African Americans is comparable to that in Asians and much greater than that in whites. Studies are needed to determine the frequency with which African Americans become isoimmunized to GPIV by transfusions and the possible contribution of this isoimmunization to platelet transfusion refractoriness in this population.
Opioid-related bowel dysfunction: prevalence and identification of predictive factors in a large sample of Italian patients on chronic treatment. (2010)

Even with the limitation of any observational experience, this study suggests, for the first time, the existence of some factors predictive of the onset of OBD symptoms in patients on analgesic treatment. Moreover, different opioids seem to be associated with a different risk of experiencing these symptoms.
Design of high-vacuum test station for rapid evaluation of vacuum microelectronic devices (1991)

A vacuum test station has been designed allowing for rapid evaluation of vacuum microelectronic devices. The system consists of a turbo-pumped vacuum chamber reaching a base pressure, at room temperature, of 3*10/sup -9/ torr. Devices which are fabricated on silicon or fused silica substrates are placed on a copper base which is part of a cold finger cryostat. Test temperatures can be varied from 20 to 500 K. Baking of the devices can be accomplished by thin-film heating elements integrated onto the substrates or by heating coils placed inside the chamber. Cleaning of electrode surfaces can be performed via an argon ion gun system and/or by electron bombardment. The performance of the system is demonstrated for a Spindt emitter array.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Architectural design of on-demand video delivery systems: the spatio-temporal storage allocation problem (2002)

The authors consider the problem of designing an on-demand video delivery system having a large number of video entities stored for distribution to a large number of customers. A logically layered information distribution network is assumed to serve the requests made by the customers. The authors propose a stochastic model for video entities in the distribution system and pose a spatio-temporal allocation problem to minimize a general cost function that includes storage, transport, and processing costs. Though such problems are generally known to be hard in terms of finding an implementable solution, the authors exploit the specific characteristics of the present problem to provide an efficient polynomial time solution. They also show a simple recursive estimation procedure to track the time-varying demand probabilities assigned to the video entities in the system. Various approaches to a practical design are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design of an active dual-mode antenna with near hemispherical Field of View coverage (2013)

A dual-mode antenna design, utilizing a combination of differential- and common-mode excitations, is presented. This antenna offers the possibility to complex-combine both modes in order to obtain a near-hemispherical Field of View (FoV) coverage. A Single-Ended (SE) to Mixed-Mode (MM) transformation model is introduced to determine the MM radiation characteristics of this antenna from SE scattering parameters and embedded element patterns. A FoV of ±90°, from zenith, is achieved with a maximum gain variation of 5 dB.
DELIVERY OF CYTOKINES AND ANTI-CANCER DRUGS BY LIPOSOMES AND IMMUNOLIPOSOMES (1993)

Journal of Immunotherapy with Emphasis on Tumor Immunology: November 1993 - Volume 14 - Issue 4 - p 360
Evolving Proteins of Novel Composition (2006)

Changing its nature: Global incorporation of noncanonical amino acids can alter the behavior of proteins in useful ways. In some cases, however, replacement of natural amino acids by noncanonical analogues (blue bars in picture) can cause loss of protein stability. After several generations, functional proteins of non-natural composition were prepared through residue-specific incorporation combined with directed evolution. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600088_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Specification of polarization parameters for optimal-performance in rain of dual circularly polarized radio links (1992)

Rain depolarization of nominally circularly polarized waves alters the polarization state of the wave to produce a polarization ellipse in which the major axis is tilted with respect to the horizontal. Tilt angles for right-hand and left-hand polarization are opposite in sign. It is shown that these tilt angles are almost independent of rain rate and only slightly dependent on frequency. At 62 GHz the magnitude of tilt is close to 60 degrees C. The suggestion is made that the antenna system be deliberately designed to match, as closely as possible, the polarization state of the incoming wave when the expected rain attenuation is at the design maximum (rain margin) for a given communications link. This strategy assures that the crosstalk between polarizations will be minimized when the signal-to-thermal noise ratio (SNR) is at its lowest value. In clear weather, the SNR will be larger, and a greater degree of polarization crosstalk can be tolerated. Finding an optimal match involves selection of the correct rotational orientation of at least one of the antennas as well as specification of its axial ratio to lie between minimum and maximum limits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MDS-Based Multiresolution Nonlinear Dimensionality Reduction Model for Color Image Segmentation (2011)

In this paper, we present an efficient coarse-to-fine multiresolution framework for multidimensional scaling and demonstrate its performance on a large-scale nonlinear dimensionality reduction and embedding problem in a texture feature extraction step for the unsupervised image segmentation problem. We demonstrate both the efficiency of our multiresolution algorithm and its real interest to learn a nonlinear low-dimensional representation of the texture feature set of an image which can then subsequently be exploited in a simple clustering-based segmentation algorithm. The resulting segmentation procedure has been successfully applied on the Berkeley image database, demonstrating its efficiency compared to the best existing state-of-the-art segmentation methods recently proposed in the literature.
SSE-PT: Sequential Recommendation Via Personalized Transformer (2020)

Temporal information is crucial for recommendation problems because user preferences are naturally dynamic in the real world. Recent advances in deep learning, especially the discovery of various attention mechanisms and newer architectures in addition to widely used RNN and CNN in natural language processing, have allowed for better use of the temporal ordering of items that each user has engaged with. In particular, the SASRec model, inspired by the popular Transformer model in natural languages processing, has achieved state-of-the-art results. However, SASRec, just like the original Transformer model, is inherently an un-personalized model and does not include personalized user embeddings. To overcome this limitation, we propose a Personalized Transformer (SSE-PT) model, outperforming SASRec by almost 5% in terms of [email protected] on 5 real-world datasets. Furthermore, after examining some random users’ engagement history, we find our model not only more interpretable but also able to focus on recent engagement patterns for each user. Moreover, our SSE-PT model with a slight modification, which we call SSE-PT++, can handle extremely long sequences and outperform SASRec in ranking results with comparable training speed, striking a balance between performance and speed requirements. Our novel application of the Stochastic Shared Embeddings (SSE) regularization is essential to the success of personalization. Code and data are open-sourced at https://github.com/wuliwei9278/SSE-PT.
The localization and concentration of  the<i>PDE2</i>-encoded high-affinity cAMP phosphodiesterase is regulated by cAMP-dependent protein kinase A in the yeast<i>Saccharomyces cerevisiae</i> (2009)

The genome of the yeast Saccharomyces cerevisiae encodes two cyclic AMP (cAMP) phosphodiesterases, a low-affinity one, Pde1, and a high-affinity one, Pde2. Pde1 has been ascribed a function for downregulating agonist-induced cAMP accumulation in a protein kinase A (PKA)-governed negative feedback loop, whereas Pde2 controls the basal cAMP level in the cell. Here we show that PKA regulates the localization and protein concentration of Pde2. Pde2 is accumulated in the nucleus in wild-type cells growing on glucose, or in strains with hyperactive PKA. In contrast, in derepressed wild-type cells or cells with attenuated PKA activity, Pde2 is distributed over the nucleus and cytoplasm. We also show evidence indicating that the Pde2 protein level is positively correlated with PKA activity. The increase in the Pde2 protein level in high-PKA strains and in cells growing on glucose was due to its increased half-life. These results suggest that, like its low-affinity counterpart, the high-affinity phosphodiesterase may also play an important role in the PKA-controlled feedback inhibition of intracellular cAMP.