gebhart/patrepeval huggingface dataset:
Methylphenidate in Hyperkinetic Children: Differences in Dose Effects on Impulsive Behavior (1979)

This research tested the hypothesis that in hyperactive children a low dose of methylphenidate (0.3 mg/kg) would produce scores superior to those with a high dose (1.0 mg/kg) or placebo on the matching familiar figures test (MFF), a primary index of impulsivity. The hypothesis was based on an earlier finding that the highest percentage of correct responses on a short-term memory task were found in hyperactive subjects who were receiving 0.3 mg/kg of methylphenidate whereas at 1.0 mg/kg the percentage correct returned to the placebo level. The hypothesis was verified in that the low dose reduced the number of errors on the MFF significantly more than did placebo or the high dose. This work demonstrates that, for both learning and impulsivity in hyperactive children, the lower dose of the two doses of methylphenidate studied produced the preferable effect.
A Cooperative Copper Metal–Organic Framework‐Hydrogel System Improves Wound Healing in Diabetes (2016)

Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes. Herein we set out to assess whether copper metal organic framework nanoparticles (HKUST-1 NPs) embedded within an antioxidant thermoresponsive citrate-based hydrogel would decrease copper ion toxicity and accelerate wound healing in diabetic mice. HKUST-1 and poly-(polyethyleneglycol citrate-co-<i>N</i>-isopropylacrylamide) (PPCN) were synthesized and characterized. HKUST-1 NP stability in a protein solution with and without embedding them in PPCN hydrogel was determined. Copper ion release, cytotoxicity, apoptosis, and <i>in vitro</i> migration processes were measured. Wound closure rates and wound blood perfusion were assessed <i>in vivo</i> using the splinted excisional dermal wound diabetic mouse model. HKUST-1 NP disintegrated in protein solution while HKUST-1 NPs embedded in PPCN (H-HKUST-1) were protected from degradation and copper ions were slowly released. Cytotoxicity and apoptosis due to copper ion release were significantly reduced while dermal cell migration <i>in vitro</i> and wound closure rates <i>in vivo</i> were significantly enhanced. <i>In vivo</i>, H-HKUST-1 induced angiogenesis, collagen deposition, and re-epithelialization during wound healing in diabetic mice. These results suggest that a cooperatively stabilized, copper ion-releasing H-HKUST-1 hydrogel is a promising innovative dressing for the treatment of chronic wounds.
Cutting Edge: Secondary Lymphoid-Tissue Chemokine (SLC) and CC Chemokine Receptor 7 (CCR7) Participate in the Emigration Pathway of Mature Dendritic Cells from the Skin to Regional Lymph Nodes (1999)

Abstract Dendritic cells (DCs) emigrate to regional lymph nodes (LNs) during immune responses via afferent lymphatic channels. Secondary lymphoid-tissue chemokine (SLC), a CC chemokine, is expressed in secondary lymphoid organs and mediates the chemotaxis of lymphocytes and DCs via its receptor, CC chemokine receptor 7 (CCR7). By dual-label fluorescence confocal microscopy, we showed MHC class II-positive cells within SLC-staining lymphatic channels in the mouse dermis. SLC was a potent in vitro chemoattractant for cultured, migratory skin DCs, and it enhanced the emigration of MHC class II-positive DCs from mouse skin explants by an average of 2.5-fold. Mature or cytokine-activated, but not resting, Langerhans cells expressed CCR7 mRNA by RT-PCR. Anti-SLC Abs, but not control or anti-eotaxin Abs, blocked the in vivo migration of 51Cr-labeled, skin-derived DCs from footpads to draining LNs by 50% (n = 9, p &lt; 0.005). Thus, we provide direct evidence that SLC and CCR7 participate in the emigration of DCs from peripheral tissue to LNs via lymphatics.
A 1.8V 12-bit 230-MS/s pipeline ADC in 0.18&#x03BC;m CMOS technology (2008)

This paper describes the implementation of a 12-bit 230 MS/s pipelined ADC using a conventional 1.8 V, 0.18 mum digital CMOS process. Two-stage folded cascode OTA topology is used for improved settling performance. Extreme low-skew (less than 3 ps peak-to-peak) chip-level clock distribution is ensured by five-level balanced clock tree, implemented in low swing current-mode logic. The ADC block achieves a peak SFDR of 71.3 dB and 9.26 ENOB at 230 MS/s, with an input signal swing of 1.5 Vpp. The measured peak SFDR at 200 MS/s is 78 dB, while the peak SNDR at 200 MS/s is 59.5 dB. The SFDR and SNDR performance exhibits very flat characteristics, maintaining higher than 53 dB SNDR at 230 MS/s and higher than 58 dB SNDR at 200 MS/s, from DC through Nyquist rate input frequencies.
Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols (2018)

Huntington's Disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the exon-1 of the IT15 gene encoding the protein Huntingtin. Expression of mutated Huntingtin in humans leads to dysfunction and ultimately degeneration of selected neuronal populations of the striatum and cerebral cortex. Current available HD therapy relies on drugs to treat chorea and control psychiatric symptoms, however, no therapy has been proven to slow down disease progression or prevent disease onset. Thus, although 24 years have passed since HD gene identification, HD remains a relentless progressive disease characterized by cognitive dysfunction and motor disability that leads to death of the majority of patients, on average 10-20 years after its onset. Up to now several molecular pathways have been implicated in the process of neurodegeneration involved in HD and have provided potential therapeutic targets. Based on these data, approaches currently under investigation for HD therapy aim on the one hand at getting insight into the mechanisms of disease progression in a human-based context and on the other hand at silencing mHTT expression by using antisense oligonucleotides. An innovative and still poorly investigated approach is to identify new factors that increase neurogenesis and/or induce reprogramming of endogenous neuroblasts and parenchymal astrocytes to generate new healthy neurons to replace lost ones and/or enforce neuroprotection of pre-existent striatal and cortical neurons. Here, we review studies that use human disease-in-a-dish models to recapitulate HD pathogenesis or are focused on promoting <i>in vivo</i> neurogenesis of endogenous striatal neuroblasts and direct neuronal reprogramming of parenchymal astrocytes, which combined with neuroprotective protocols bear the potential to re-establish brain homeostasis lost in HD.
Molecular Dynamics in Ordered Structures: Computer Simulation and Experimental Results for Nylon 66 Crystals (1990)

A detailed comparison between molecular dynamics computer simulations and the experimental characterization of molecular motion through deuterium nuclear magnetic resonance (NMR) spectroscopic methods has been carried out for the crystalline phase of nylon 66 (polyhexamethyleneadipamide) at room temperature and just below the melting point. The computer simulations agree quantitatively with the experimental results at room temperature and qualitatively near the crystalline melting point. Both methods demonstrate that individual methylene groups within the crystals exhibit librational motion, which becomes very large in amplitude near the melting point, rather than undergoing discrete conformational jumps; furthermore, the hydrogen-bonded amides are relatively immobile at all temperatures below 230 degrees Celsius. The simulations are shown to be particularly useful for exaning the cooperativity of motion and for providing insight into structural-dynamical correlations. These aspects of the simulations are exemplified by the observation of concerted counterrotation of odd-numbered bonds within the methylene segments and the entropic stabilization of the crystal structure.
Photolabile derivatives of bile salts. Synthesis and suitability for photoaffinity labeling. (1983)

In an approach to the identification of bile salt-binding carriers, the photoactivable bile acid derivatives A) 3 beta-azido, 7 alpha,12 alpha-dihydroxy-5 beta-cholan-24-oic acid, B) 7,7-azo-3 alpha,12 alpha-dihydroxy-5 beta-cholan-24-oic acid, and C) 11 xi-azido-12-oxo-3 alpha,7 alpha-dihydroxy-5 beta-cholan-24-oic acid were synthesized in unconjugated and taurine-conjugated form. Photolysis of the 3 beta-azido derivatives was studied using a light source with a maximum emission at 300 nm and established a half-life time of 18.5 min. The photochemistry of the 7,7-azo derivatives was investigated using light with a maximum at 350 nm and had a half-life time of 2.2 min. The 11 xi-azido-12-oxo derivatives were photolyzed with light having a maximum at 300 nm resulting in a half-life time of 8.5 min. The suitability of the 7,7-azo derivatives for photoaffinity labeling was demonstrated by photolyses in 14C-labeled methanol and acetonitrile. The generated carbene reacted with the solvents under covalent bond formation of 6 to 12%. The efficiency of all synthesized photolabile derivatives for photoaffinity labeling of bile salt binding proteins was demonstrated.
ChemInform Abstract: Chemistry of Ingenol. Part 4. Ingenol from Seeds of Euphorbia lathyris L. and Preparation of (9R)((9S))‐9‐Deoxo‐9‐hydroxyingenol with Some Corresponding 3‐ and 9‐Esters. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Smectite for acute diarrhoea in children (2005)

A short cut review was carried out to establish whether smectite was a useful therapy in acute diarrhoea. A total of 21 papers were found of which five presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these best papers are tabulated. The clinical bottom line is that oral smectite appears to be effective at shortening the duration of the diarrhoea in children with acute diarrhoea rehydrated with oral rehydration solution.
Tetrahydroisoquinolines. I. 1-Alkyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetrahydroisoquinolines. I. 1-Alkyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines1P. N. Craig, F. P. Nabenhauer, P. M. Williams, E. Macko, and J. TonerCite this: J. Am. Chem. Soc. 1952, 74, 5, 1316–1317Publication Date (Print):March 1, 1952Publication History Published online1 May 2002Published inissue 1 March 1952https://pubs.acs.org/doi/10.1021/ja01125a051https://doi.org/10.1021/ja01125a051research-articleACS PublicationsRequest reuse permissionsArticle Views235Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RADIOGRAPHICALLY VISUALIZED SKELETAL CHANGES ASSOCIATED WITH MUCOPOLYSACCHARIDOSIS VI IN CATS (1987)

The radiographic skeletal form and structure of all cats with mucopolysaccharidosis VI is described. Common manifestations included epiphyseal dysplasia, generalized osteoporosis, abnormal nasal turbinate development, his subluxation, impaired development of skeletal growth, pectus excavatum, hyoid hypoplasia, aplasia, hypoplasia and fragmentation or abnormal ossification of the dens, and aplasia or hypoplasia of frontal and sphenoid sinuses. The skeletal measurements of two affected cats were compared with those of normal, sex‐matched littermates, and the measurements of two affected female cats were compared with those of a normal male littermate.
Estimation for Markowitz Efficient Portfolios (1980)

Abstract Given a set of N assets a portfolio is determined by a set of weights xi, i = 1, 2, …, N; Σ N i=1 xi = 1 indicating the proportion of the value of the portfolio devoted to each asset. A Markowitz efficient portfolio is the vector of weights X m that minimizes the variance σ m 2 of the total return from the portfolio, subject to the condition that the portfolio mean premium return μ m has a certain value. The estimators for the N × 1 vector X m , the return premium μ m , and the variable σ m 2 require estimators for the mean premium return vector and for the covariance matrix Σ. The expectations, variances, and asymptotic distributions of the estimators of X m , μ m , and σ m 2 are derived under the assumption that returns are normally distributed. The use of these sampling properties for statistical inference is also discussed. The derived results are also compared with results obtained from a Monte Carlo simulation for a population of 20 stocks and several sample sizes.
Noncovalent Functionalization of Boron Nitride Nanotubes in Aqueous Media Opens Application Roads in Nanobiomedicine (2014)

Boron nitride nanotubes (BNNTs) are of intense scientific interest due to their unique physiochemical properties and prospective applications in various nanotechnologies, particularly nanobiomedicine. A critical problem hampering the application processing of BNNTs is the outer sidewall functionalization, which is primarily acquired to lead BNNTs dispersible in various solvents. Furthermore, the surface of BNNTs should be intelligently designed and precisely controlled to satisfy the specific demands of different applications. For these purposes, covalent and noncovalent approaches have been factually developed to help to extend the full potential of applications. Importantly, wrapping the outermost sidewall of BNNTs with either water-soluble polymers or biomolecules through weak noncovalent interactions has been proved to be efficient for giving BNNTs considerable dispersity in aqueous media, and endowing novel chemical functions to BNNTs with almost no change in their pristine physiochemical properties. This article summarizes recent progress in this field and addresses future perspectives on the noncovalent functionalization of BNNTs for promoting their application processing in various bio-related nanotechnologies.
Web application modeling for testing and analysis (2008)

The goal of my work is to improve quality assurance techniques for web applications. I will develop automated techniques for modeling web applications and use these models to improve testing and analysis of web applications.
The Medicare Prescription Drug Benefit: How Will The Game Be Played? (2000)

Most recent proposals to add a prescription drug benefit to the Medicare program suggest using pharmacy benefit managers (PBMs) to control costs and promote quality. However, the proposals give little detail on the institutional arrangements that would govern PBM operations and drug procurement. The recent Congressional Budget Office cost estimate of the Clinton administration's proposal reflects this lack of detail on how PBMs would function. We sketch an approach for structuring PBM operations that focuses on competition among PBMs, manufacturers, and distributors; incentive pricing; and risk sharing with PBMs.
Postnatal treadmill exercise attenuates prenatal stress-induced apoptosis through enhancing serotonin expression in aged-offspring rats (2015)

Maternal stress during pregnancy affects negative impact on health of offspring. In the present study, we compared the effects of maternal treadmill exercise and offspring treadmill exercise on prenatal stress-induced apoptosis and serotonin expression in offspring. Stress to the pregnant rats was induced by exposure of maternal rats to the hunting dog in an enclosed room. Exposure time was 10 min, three times per day, with a 1-h interval between exposures. This regimen was maintained from the seventh day of gestation until delivery. The pregnant rats in the exercise group were forced to run on a motorized tread-mill for 30 min once a day, started 7 days after pregnancy until delivery. The offspring in the exercise group were forced to run on a motorized treadmill for 30 min once a day, started 4 weeks after birth for 4 weeks. In the present results, offspring exposed to prenatal stress exhibited lower Bcl-2 level and higher Bax level in the hippocampus, lower 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) expression in the dorsal raphe, and higher c-Fos expression in the locus coeruleus compared to age-matched control rats. Treadmill exercise of offspring suppressed Bax expression and enhanced Bcl-2 expression in the hippocampus, increased 5-HT and TPH expression in the dorsal raphe, and enhanced c-Fos expression in the locus coeruleus of offspring. Tread-mill exercise of offspring suppressed prenatal stress-induced apoptosis and normalized prenatal stress-induced alterations in serotonin synthesis and neuronal activation. However maternal treadmill exercise during pregnancy exerted no significant effect on offspring.
The Upgrade of the Advanced Photon Source (2018)

After decades of successful operation as a 7-GeV synchrotron radiation source, the Advanced Photon Source is pursing a major upgrade that involves replacement of the storage ring with an ultra-low emittance multi-bend achromat design. Using a seven-bend hybrid multi-bend achromat with reverse bending magnets gives a natural emittance of 42 pm operated at 6 GeV. The x-ray brightness is predicted to increase by more than two orders of magnitude. Challenges are many, but appear manageable based on thorough simulation and in light of the experience gained from world-wide operation of 3^{\}text{rd}-generation light sources. The upgraded ring will operate in swap-out mode, which has allowed pushing the performance beyond the limits imposed by conventional operation.
Twin screw extruders as polymerization reactors for a free radical homo polymerization (1993)

The bulk polymerization of n-butylmethacrylate was investigated in a counter-rotating twin screw extruder. It appeared that the gel effect, occurring with bulk polymerizations, affected the polymerization progress very strongly. Due to this effect the conversion of the reaction is independent of the rotation speed of the screws. The reactive extrusion diagram, presented in this paper, indicates how the different phenomena interact with each other and helps to understand the influences of extruder parameters and reaction parameters on the process. On a étudié la polymérisation en masse du n-butylméthacrylate dans une extrudeuse bivis contra-rotatives. Il est apparu que ľeffet de gel, se produisant avec les polymérisations en masse, influe très fortement le cours de la polymérisation. Pour cette raison, la conversion de la réaction est indépendante de la vitesse de rotation des vis. Le diagramme ďextrusion réactive, présenté dans cet article, indique comment les divers phénomènes agissent entre eux et aide à mieux comprendre les influences des paramètres de ľextrudeuse et des paramètres de réaction sur le procédé.
The Biceps Femoris Muscle Complex at the Knee (1996)

We dissected 30 cadaveric knees to provide a detailed anatomic description of the biceps femoris muscle complex at the knee. The main components of the long head of the muscle are a reflected arm, a direct arm, an anterior arm, and a lateral and an anterior aponeurosis. The main components of the short head of the biceps femoris muscle are a proximal attachment to the long head's tendon, a capsular arm, a confluens of the biceps and the capsuloosseous layer of the iliotibial tract, a direct arm, an anterior arm, and a lateral aponeurosis. We examined 82 consecutive, acutely injured knees with clinical signs of anterolateral-anteromedial rotatory instability for the incidence and anatomic location of injuries to the biceps femoris muscle. Injuries to components of that muscle were identified in 59 (72%) of these knees; 29 knees (35.4%) had multiple components injured. There were 3 injuries to the long head of the biceps femoris muscle (all in the reflected arm) and 89 to the short head. A statistically significant correlation (P = 0.01) was found between increased anterior translation with the knee at 25 degrees of flexion as demonstrated by the Lachman test and injury to the biceps-capsuloosseous iliotibial tract confluens. Additionally, adduction laxity at 30 degrees of flexion correlated with a Segond fracture (P = 0.04). These data establish, in part, the relationship of the biceps femoris complex injury to anterior translation instability.
Synthesis, properties and applications of nanoscale nitrides, borides and carbides (2012)

Nanoscale nitrides, borides and carbides are a fascinating type of materials, which have aroused tremendous and continuous research interest for decades owing to their special mechanical, electrical, optical, photoelectronic, catalytic properties and widespread uses. In this feature article, recent developments and breakthroughs in the synthesis, properties and applications of nanometre scale nitrides (BN, Si(3)N(4), GaN, noble nitrides), borides (LnB(6), LnB(2), Fe(3)BO(5), LiMBO(3)) and carbides (carbon, SiC, TiC, NbC, WC) were briefly reviewed in sequence of their different dimensions (1D, 2D and 3D). In particular, our latest advances in the "autoclave route" fabrication of nanoscale nitrides, borides, and carbides were highlighted. The challenges, issues and perspectives of the synthetic methodologies and potential applications concerning the above-mentioned materials were also briefly discussed.
A non-acid-fast coccoid precursor--possible cultivable phase of Mycobacterium leprae. (1976)

A non-acid-fast coccoid organism isolated from human leproma, and skin and nasal smears of leprosy patients shows tendency to revert to an acid-fast mycobacterial form during test tube passages. One of these coccoid isolates gave strong DOPA oxidase activity. There is also preliminary evidence of mycobacterial conversion from these coccoids in intraperitoneally inoculated mice. The possibility that these non-acid-fast coccoids could be a cultivable precursor phase of M. leprae has been raised and discussed.