gebhart/patrepeval huggingface dataset:
Trapping and cooling of 174Yb+ ions in a microfabricated surface trap (2013)

Trapped atomic ions are the leading candidate to act as individual quantum bits in a large quantum information processing system. Ion traps can be conformed to a two-dimensional surface, which provides a way to increase the number of ions while maintaining the ability to move individual ions in a two-dimensional grid. However, surface traps tend to suffer from shallow trap depths and higher motional heating rates. In this work, we report the design, fabrication, and testing of a simple gold-on-fused-silica ion trap optimized for a deep trapping potential and stable motional modes. The desirable trap characteristics include long lifetime, fully-compensated micromotion, and high secular trap frequencies that were measured using a trapped and cooled 174Yb+ ion. This trap design can be integrated with an optical cavity to enhance the ion-photon coupling.
Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells (1992)

We isolated four monoclonal antibodies (MAbs), M38, M101, M104, and C33, which were capable of inhibiting syncytium formation induced in a human T-cell line, MOLT-4-#8, by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines. The MAbs had, however, no inhibitory activity on syncytium formation induced in a human osteosarcoma line, HOS, by HTLV-1-positive T-cell lines. They also did not inhibit syncytium formation induced in MOLT-4-#8 by human immunodeficiency virus type 1-positive MOLT-4. All MAbs reacted with various human cell lines of lymphoid and nonlymphoid origins, including HTLV-1-positive T-cell lines. Furthermore, they all reacted with a murine A9 clone containing human chromosome 11 fragment q23-pter. Two MAbs, M104 and C33, immunoprecipitated a membrane antigen with the same molecular size. The antigen (henceforth called C33 antigen) was about 40 to 55 kDa in HTLV-1-negative Jurkat, CEM, MOLT-4, and normal peripheral blood CD4-positive human T cells and about 40 to 75 kDa in HTLV-1-positive C91/PL, TCL-Kan, MT-2, and in fresh HTLV-1-transformed CD4-positive human T-cell lines. Pulse-chase experiments revealed that C33 antigen was synthesized as a 35-kDa precursor that was then processed to 41 to 50 kDa in MOLT-4 and to 44 to 70 kDa in C91/PL. In the presence of tunicamycin, a 28-kDa protein was synthesized. The conversion from 35 kDa to 41 to 50 kDa in MOLT-4 and to 44 to 70 kDa in C91/PL was inhibited by monensin. Treatment with N-glycanase alone, but not with sialidase and O-glycanase in combination, completely removed the sugar moiety of C33 antigen from both HTLV-1-negative Jurkat and HTLV-1-positive C91/PL. Therefore, C33 antigen has only N-linked carbohydrates, the modification of which appears to be substantially altered in the presence of the HTLV-1 genome.
SRA SOLOMON (1992)

In this paper, we report SRA's results on the MUC-4 task and describe how we trained our natural language processing system for MUC-4. We also report on what worked, what didn't work, and lessons learned. Our MUC-4 system embeds the SOLOMON knowledge-based NLP shell which is designed for both domain-independence and language-independence. We are currently using SOLOMON for a Spanish and Japanese text understanding project in a different domain. Although this was our first year participating in MUC, we have built and are currently building other data extraction systems.
In vitro tolerance induction of primed, IgD-negative murine spleen cells. (1981)

The above observations demonstrated induction of immunological tolerance in vitro in primed IgD-, IgG+ B cells. In these studies, addition of trinitrophenylated (TNP) turkey gammaglobulin (TGG) or TNP ovalbumin conjugates suppressed the secondary in vitro response in mice primed with TNP keyhole limpet hemocyanin (TNP-KLH). Suppression was not a reflection of a shift in kinetics of the antibody response, was not dependent on suppressor T cells, and could only be eliciate when conjugate was added within 4 h of addition of TNP-KLH moreover, preincubation of the primed spleen cells with TNP-TGG for 20 h at 37 degrees C, followed by extensive washing, was as effective in inhibiting the response to TNP-KLH as when TNP-TGG was present throughout the 5 d of culture, reflecting induction of a tolerant state. Amounts of conjugate in the concentration range that have been shown by others to tolerize immature or neonatal B cells or mature B cells that have been stripped of surface IgD were sufficient to induce tolerance. The target cells being tolerized did not bear IgD, as determined by B cell depletion and blocking procedures with anti IgD. Whether the lack of surface IgD on the primed cells contributed to the relative ease of tolerance induction was not established by these studies, but the advantages of using primed B cells to examine further the role of surface IgD in tolerance susceptibility was discussed.
Characterization of Enteropathogenic and Enteroaggregative <i>Escherichia coli</i> Isolated from Diarrheal Outbreaks (2002)

Virulence characteristics of diarrheal outbreak-associated Escherichia coli O55:NM, O126:NM, and O111:NM were examined. The E. coli O55:NM strains were atypical enteropathogenic E. coli (EPEC), while the E. coli O126:NM and O111:NM strains should be classified as enteroaggregative E. coli (EAggEC). The contributions of EPEC and EAggEC to the human disease burden in Japan might be significantly greater than is currently appreciated.
Performance analysis of parallel computing in a distributed overlay network (2011)

There are many data and computation intensive applications that generally require very high performance and a lot of computing resources which lead to the increase in the overall execution time. Parallel computing can improve overall execution time which involves breaking up large program into smaller pieces that can be executing in multi processors system. While, distributed computing offers some advantages for parallel computing, where multiple connected processors can run in parallel by contributing their computing time and memory storage. However, due to the nature of heterogeneity of processing power in distributed computing, the effect of imbalance of workload distribution between processors is an important factor to be taken into consideration. In this paper, we conducted simulations of Pi value computation for tree-based distributed system under several of types of workloads distributions. We measured the overall execution time to study and analyze the effect of different workloads distribution. From our simulation results, we found that the increment of waiting time for a processor to receive back a result significantly impact the overall execution time as well as the scalability of the distributed system.
Time-of-Flight Imaging: Algorithms, Sensors and Applications (Dagstuhl Seminar 12431) (2013)

This report documents the program and the outcomes of Dagstuhl Seminar 12431 "Time-of-Flight Imaging: Algorithms, Sensors and Applications". The seminar brought together researchers with diverse background from both academia and industry to discuss various aspects of Time-of-Flight imaging and general depth sensors. The executive summary and abstracts of the talks given during the seminar as well as the outcome of several working groups on specific research topics are presented in this report.
Dipeptidylpeptidase IV Activities Are Elevated in Prostate Cancers and Adjacent Benign Hyperplastic Glands (2000)

Dipeptidylpeptidase IV (DPP IV) is a serine exopeptidase that has been implicated in cell-extracellular matrix interactions and bioactive peptide/cytokine/growth factor metabolism. The objective of this study was to determine if DPP IV activities were changed with development of cancer in the prostate. DPP IV activity was measured in human prostate cancer and benign prostatic hyperplasia (BPH) tissues by biochemical assays with glycylprolyl-p-nitroanalide as substrate in tissue extracts (BPH, n = 8: cancer, n = 7; 2 with Gleason score 5 and 5 with Gleason score 7) and quantitative morphometry of histochemical activities with glycylproline-4-methoxy-beta-naphthylamide as substrate (BPH, n = 9: cancer, n = 13, 1 with Gleason score 4, 10 with Gleason score 6, 2 with Gleason score 8) in frozen-tissue sections. Data were analyzed by analysis of variance. The peptidase activity was detected in epithelial but not stromal cells of BPH and cancer tissues, and it was present as a single band of activity of approximately 160 kDa in electrophoretically separated activity blots of the extracts. DPP IV activity was increased approximately twofold in cancer versus BPH tissues as determined by biochemical and quantitative histochemical methods. In addition, DPP IV activity was increased to a similar extent in BPH glands associated with the cancers. These data indicate that DPP IV activity is increased not only in primary prostatic cancers but also in associated BPH glands, suggesting that there may be some local factors produced by cancer cells that influence adjacent BPH epithelial cells to positively affect the immediate growth environment of the cancer.
Fast integration of heterogeneous data sources for predicting gene function with limited annotation (2010)

Networks and code are available from: http://morrislab.med.utoronto.ca/sara/SW
Macrophage Inflammatory Protein 1α/CCL3 Is Required for Clearance of an Acute<i>Klebsiella pneumoniae</i>Pulmonary Infection (2001)

The objective of these studies was to determine the role of macrophage inflammatory protein 1alpha/CCL3 in pulmonary host defense during Klebsiella pneumoniae infection. Following intratracheal inoculation, 7-day survival of CCL3(-/-) mice was less than 10%, compared to 60% for CCL3(+/+) mice. Survival of CCR5(-/-) mice was equivalent to that of controls, indicating that the enhanced susceptibility of CCL3(-/-) mice to K. pneumoniae is mediated via another CCL3 receptor, presumably CCR1. At day 3, CFU burden in the lungs of CCL3(-/-) mice was 800-fold higher than in CCL3(+/+) mice, demonstrating that CCL3 is critical for control of bacterial growth in the lung. Surprisingly, CCL3(-/-) mice had no differences in the recruitment of monocytes/macrophages and even showed enhanced neutrophil recruitment at days 1, 2, and 3 postinfection, compared to CCL3(+/+) mice. Therefore, the defect in clearance was not due to insufficient recruitment of leukocytes. No significant differences in cytokine levels of monocyte chemoattractant protein 1 (MCP-1), interleukin 12, gamma interferon, or tumor necrosis factor alpha in lung lavages were found between CCL3(+/+) and CCL3(-/-) mice. CCL3(-/-) alveolar macrophages were found to have significantly lower phagocytic activity toward K. pneumoniae than CCL3(+/+) alveolar macrophages. These findings demonstrate that CCL3 production is critical for activation of alveolar macrophages to control the pulmonary growth of the gram-negative bacterium K. pneumoniae.
RORγt and RORα signature genes in human Th17 cells (2017)

RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characterized in mouse Th17 cells, detailed information on its transcriptional control in human Th17 cells is limited and even less is known about RORα signature genes which have not been reported in either human or mouse T cells. In this study, global gene expression of human CD4 T cells activated under Th17 skewing conditions was profiled by RNA sequencing. RORγt and RORα signature genes were identified in these Th17 cells treated with specific siRNAs to knock down RORγt or RORα expression. We have generated selective small molecule RORγt modulators and they were also utilized as pharmacological tools in RORγt signature gene identification. Our results showed that RORγt controlled the expression of a very selective number of genes in Th17 cells and most of them were regulated by RORα as well albeit a weaker influence. Key Th17 genes including IL-17A, IL-17F, IL-23R, CCL20 and CCR6 were shown to be regulated by both RORγt and RORα. Our results demonstrated an overlapping role of RORγt and RORα in human Th17 cell differentiation through regulation of a defined common set of Th17 genes. RORγt as a drug target for treatment of Th17 mediated autoimmune diseases such as psoriasis has been demonstrated recently in clinical trials. Our results suggest that RORα could be involved in same disease mechanisms and gene signatures identified in this report could be valuable biomarkers for tracking the pharmacodynamic effects of compounds that modulate RORγt or RORα activities in patients.
Conference Report on Public Health and Clinical Guidelines for Anthrax (2008)

On March 13-14, 2006, a meeting on anthrax, sponsored by the Centers for Disease Control and Prevention (CDC) in collaboration with the Southeastern Center for Emerging Biologic Threats, was held at Emory University in Atlanta, Georgia, USA. The meeting's agenda included discussion of postexposure prophylaxis (PEP), screening and evaluation, and treatment of the various manifestations of human anthrax. The goal was to convene subject matter experts for a review of research developments and clinical experience with anthrax prophylaxis and treatment and to make consensus recommendations for updating guidelines for PEP, treatment, and clinical evaluation of patients with anthrax. A 2001 conference on guidelines for anthrax has previously been summarized in this journal. This article summarizes the meeting's presentations and discussion. Consensus recommendations are summarized in the Table. Updated CDC guidelines for treatment and prophylaxis of anthrax will be published in detail in other CDC publications and are available on CDC's website at http://www.bt.cdc.gov/agent/anthrax/index.asp.
A Noise-Reducing Enclosure for a Four-Die Swager (1963)

First Page
Secagem racional da madeira (1985)

A falta de um texto básico sobre a secagem da madeira no Brasil, reunindo os princípios e as informações sobre como reduzir racionalmente o seu teor de umidade para o melhor comportamento em uso, motivou a elaboração do presente livro. Visou-se atender aos universitários, profissionais florestais, empresários e técnicos do setor de processamento e moveleiro, e a todos que, de uma forma geral, trabalham com a madeira e seus produtos. O texto é baseado em aulas de graduação e pós-graduação do curso de Engenharia Florestal da Universidade de São Paulo (Escola Superior de Agricultura Luiz de Queiroz). Aborda a secagem, considerando especialmente as condições e as necessidades locais, assim como as espécies florestais utilizadas no Brasil. Evidentemente, não pretende esgotar o assunto e trata principalmente da secagem em estufas ou secadores. Considerando os objetivos visados, os princípios físicos envolvidos no processo de redução do teor da água são apresentados de uma forma simples e sem maiores detalhes. Contudo, aos interessados é indicada a bibliografia pertinente.
Holographic radio interferometry for target tracking in dense multipath indoor environments (2017)

The Radio Interferometric Positioning System (RIPS) is a phase-based localization scheme that achieves high accuracy with low-cost devices. Indoor localization with RIPS is, however, a challenge due to dense multipath. In this paper, we propose holographic radio interferometry (HRI) to cope with multipath effect. HRI builds hologram out of phase measurements in radio interferometry for the mobile target. It is built on an important observation that spatial diversity induced by dense multipath resembles that induced by random noise. We implement HRI with GNU Radio/USRP N210 and test it in lab environments. With mobility data from only one step, HRI achieves a median positioning error of 21 cm, in contrast to 151 cm with the original RIPS. It is also verified that HRI is robust to errors in mobility data. The median positioning error is no more than 66 cm with a speed error of the target up to 15 cm/s and a direction error up to 2.5°.
Mark II Test Vehicle Holder for in Situ Viewing of Integrated Circuit Electr0Migrati0N (1986)

A patent pending test holder was designed to support research in electromigration using a JEOL 100 CX STEM. The holder provides electrical connections for an aluminum stripe test vehicle which allows the electromigration process to be conducted within the microscope. The holder is specifically designed for use in conjunction with a JEOL-type electron microscope side entry goniometer. Four leads provide the ability to power three different test stripes on one test vehicle. This allows three separate electromigration runs/observations in-situ without removing the test vehicle from the STEM, thus minimizing test vehicle time outside the vacuum environment.
QUALITY CONTROL IN DISTRIBUTION (1971)

The water that leaves the utility plant rarely has the same quality when it enters the customer's premises. To ensure minimum change in the water during its passage through delivery pipes, the utility can take the actions recommended in this article.
Microring and microdisk resonator integrated circuits on a silicon chip (2007)

We report our latest experimental and numerical work on silicon microresonator passive and electro-optic active devices. On the passive device front, we demonstrate an electrically tunable silicon microring notch filter for converting 3.6-Gbps non-return-to-zero (NRZ) data format to return-to-zero (RZ)-like data format. We show that the converted RZ-like data quality highly depends on the notch filter extinction ratios. On the active device front, we demonstrate a silicon microring modulator using a double-coupled U-bend waveguide as a feedback and a pair of laterally integrated injectiontype p-i-n diodes for bias/signal modulation. We show that the microring modulator extinction ratios are electrically controlled by applying a DC-bias across either the feedback-waveguide or the microring while applying a modulation signal across the other p-i-n diode. We also propose silicon microdisk modulators with selectively integrated depletiontype Schottky diodes. Our numerical simulations suggest that the microdisk structures can be advantageous compared with microring structures. We show that electrical rise time on the order of a few ps is feasible using microdisks. We also allude to on-going work on extending the microresonator devices discussed here to building functional silicon optoelectronics integrated circuits.
Expression of complement components and inhibitors on platelet microparticles (2008)

Platelet microparticles (PMP) are released from activated platelets and play an important role in hemostasis, thrombosis and inflammation. Since platelets were recently found to demonstrate an intrinsic capacity for activating both classical and alternative pathways of the complement system, the present study extended these observations to PMP. PMP were generated by treating platelets with 10 microM A23187 (37 degrees C, 5 min). PMP were identified by flow cytometry, based on size, Annexin V binding, and expression of P-selectin and GPIIb (CD41). PMP expressed gC1qR/p33, a multifunctional cellular protein that was recently described to activate the classical complement cascade. PMP also expressed the classical pathway and contact system regulator, C1 inhibitor (C1-INH), as well as CD55 and CD59. Despite C1-INH expression, PMP supported classical pathway C4 activation in the presence of purified C1 and C4. Moreover, statistically significant deposition of C3b and C5b-9 was detected on PMP exposed to plasma, concurrently with expression of CD55 and CD59. These data provide the first evidence for the ability of PMP to support in situ complement activation. Complement activation contributes to a variety of vascular and inflammatory disease states including atherosclerosis and ischemia/reperfusion injury.
Eddy-current coupling with slotted conductor disk (2006)

Eddy-current couplings are becoming popular devices for speed and torque control. Efficiency of these couplings depends on the excitation level; therefore, the routes and density of induced currents affect it significantly. This paper focuses on the design of a squirrel cage-type coupling disk, which forces eddy currents to flow perpendicular to both magnetic field lines and the axis of rotation. Lorentz force and transmitted torque are consequently optimized. The investigation is performed both numerically and experimentally, with results being presented for variable air gaps and speeds. A comparison between plain and slotted disk conductors, tested under identical set-ups, demonstrates the effect of the proposed design on torque throughput and efficiency. In addition to this, the influence of number and size of slots and the effect of filling slots with iron are studied by parametric finite-element modeling verified by experiments.
Macro and Trace Mineral Content of Selected South Texas Deer Forages (1990)

Thomas G. Barnes, Larry W. Varner, Lytle H. Blankenship, Thomas J. Fillinger, Sharon C. Heineman, Macro and Trace Mineral Content of Selected South Texas Deer Forages, Journal of Range Management, Vol. 43, No. 3 (May, 1990), pp. 220-223
Building Blocks of Market Clearing Business Cycle Models (1989)

We compare "real business cycle" and increasing returns models of economic fluctuations. In these models, business cycles are driven by productivity changes resulting either from technology shocks or from movements along the increasing returns production function. We stress four crucial building blocks that give both types of models hope of fitting the data. These building blocks include durability of goods, specialized labor, imperfect credit and elastic labor supply. We also present new evidence on co-movement of both outputs and labor inputs across sectors and on the behavior of relative prices over the business cycle. We conclude that the increasing returns model is easier to reconcile with the data than the real business cycle model.
The occurrence of Hypsipyla shoot borer on species of exotic Meliaceae planted in the Northern Territory. (2006)

African mahogany Khaya senegalensis is the favoured species for high-value plantations in the Top End of the Northern Territory because it has outperformed others in extensive trials over 40 years. Despite its vigour, Khaya is characterised by poor form that may be related to its genetics, nutrition or chronic low level pest attack. However few pests and diseases have been recorded locally for Khaya or the other species tested.
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogs as renal vasodilators (1983)

Chain modification of a thiazolidinone prostaglandin isostere has led to the production of 4-[3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl] benzoic acid (5b) which at 1 mg/kg po in the conscious dog causes a 70% increase in renal blood flow over control values with a duration of action exceeding 5 h. Preliminary testing indicates that 5b has a relatively specific action on the vasculature of the kidney. The enantiomers of 5b have been separated and the renal vasodilatory activity has been found to be entirely a property of the R-(+) enantiomer.
Formation of native defects in the γ-ray detector material Cs2Hg6S7 (2012)

Semiconductor γ-ray detectors have broad applications, yet finding superior detector materials is a challenge because of its contradictory requirements. Here, we investigated a large set of native defects in Cs2Hg6S7 that has been suggested as a promising candidate for detector materials. Using first-principles calculations, we showed that S-vacancy and HgCs-antisite defect provide life-time limiting deep levels, and Cs-vacancy forms a shallow acceptor level, resulting in low resistivity. To decrease such detrimental effects, concentrations of defects and carriers were examined in various chemical environments, which reveal that carrier densities can be extremely reduced by adjusting Cs partial pressure.