gebhart/patrepeval huggingface dataset:
Hemodynamic aspects of the Berlin ventricle assist device (2005)

A new ventricle assist device (VAD), with an improved energy converter unit, was investigated both numerically and experimentally. An experimental continuous digital particle imaging velocimetry (CDPIV) was combined with a computational fluid dynamics (CFD) analysis. These tools complement each other to result in a comprehensive description of the complex 3D, viscous and time-dependent flow field inside the artificial heart ventricle. A 3D numerical model was constructed to simulate the VAD pump and a time-dependent CFD analysis with moving walls was performed to predict the flow field inside the VAD during the cardiac cycle. A commercial finite element package (FIDAP, Fluent Inc., Evanston) was used to solve the Navier-Stokes equations. In the experimental analysis, an optically clear elastic model of the VAD was placed inside a 2D CDPIV system. Continuous flow visualization and CDPIV calculations of the flow were used for validating the CFD simulations. Once validated, the CFD results provide a detailed 3D and time dependent description of the flow field, allowing the identification of stagnation or high shear stress regions.
Ti-precoating effect on wetting and joining of Cu to SiC. (1990)

The wettability of molten Cu on Ti-precoating SiC was evaluated by a sessile drop technique Titanium was coated by RFmagnetron sputtering in argon gas The contact angle of copper was measuredby photography at 1 373 K in a vacuum. The equilibrium contact angle of copper on SiC was improved by increasing Ti precoating thickness. The Ti-precoating improves the wetting of copper on SiC. The formation of carbide and silicide such as TiC and Ti5Si3 at CulSiC interface accounts for the good wetting of copper on SiC.
Growth-coupled overproduction is feasible for almost all metabolites in five major production organisms (2017)

Computational modelling of metabolic networks has become an established procedure in the metabolic engineering of production strains. One key principle that is frequently used to guide the rational design of microbial cell factories is the stoichiometric coupling of growth and product synthesis, which makes production of the desired compound obligatory for growth. Here we show that the coupling of growth and production is feasible under appropriate conditions for almost all metabolites in genome-scale metabolic models of five major production organisms. These organisms comprise eukaryotes and prokaryotes as well as heterotrophic and photoautotrophic organisms, which shows that growth coupling as a strain design principle has a wide applicability. The feasibility of coupling is proven by calculating appropriate reaction knockouts, which enforce the coupling behaviour. The study presented here is the most comprehensive computational investigation of growth-coupled production so far and its results are of fundamental importance for rational metabolic engineering.
High power microwave generation from a metamaterial waveguide (2016)

In this paper we present the microwave measurements from a backward-wave oscillator (BWO) that uses a negative index mode in a waveguide filled with a metamaterial. The metamaterial waveguide supports a mode with negative group velocity that is used to generate microwaves at 2.4 GHz by interacting with a 500 keV, 80 A electron beam. The waveguide is fabricated with complementary-split-ring-resonators (CSRRS) and is all metallic to allow for high power operation. Over 1 MW of microwave power has been measured from the device.
Images - September 2013 (2013)

"Images," College of DuPage's monthly one-half hour television show, features in its September edition an interview with graduate and B96 DJ Justin Roman and a feature on the College's Manufacturing Technology program. This month, on Images! Get to know radio personality Justin Roman... Maybe you know him from Stylz and Roman on Chicago's B96, or maybe you know him as the founder and front man of the band Jump Smokers. A young man with many interests and talents, Justin Roman reflects on growing up in DuPage county and the rewards of his decision to attend College of DuPage. ... COD's Manufacturing Technology program produces students for immediate job placement ... Even in the face of a tough economy, there is great need for qualified candidates to fill a wide range of available jobs in manufacturing. College of DuPage's Manufacturing Technology program prepares students to fill the increasing number of employment and career growth opportunities. ...and make a simple and spicy appetizer In the Kitchen with Chris... COD's Chef Chris Thielman shares his recipe for Nacho Chip Chicken, a fast and easy appetizer to spice up your next fiesta. All this and more in this edition of Images! Check your local cable listings for time and channel. For images! Information Contact: Kevin Willman Multimedia Services 425 Fawell Blvd. Glen Ellyn, IL 60137 630-942-3352 Willman@ cod.edu
Passive Immunization against Insulin-Like Growth Factor-I Does not Inhibit Growth Hormone- Stimulated Growth of Dwarf Rats (1991)

Passive immunization against insulin-like growth factor-I (IGF-I) was undertaken in GH-deficient rats in an attempt to elucidate the relative importance of the endocrine vs.autocrine/paracrine actions of IGF-I in stimulating growth. Antiserum against IGF-I was raised in sheep and purified by affinity chromatography. The ability of the purified antibodies to neutralize the actions of IGF-I in vitro and bind IGF-I in vivo were extensively tested using L6 myoblast and cartilage bioassays. Four groups of male rats with isolated GH deficiency were used in the study. At 49 days of age the rats received 100 microliter normal saline given sc each day for 10 days, 2 mg/kg recombinant bovine GH (bGH) given in 100 microliter, sc, each day, 2 mg/kg bGH, sc, and 300 microliter immunoglobulin G purified from normal sheep serum given daily ip, or 2 mg/kg bGH plus 300 microliter anti-IGF-I immunoglobulin G daily, ip (a dose that was able to completely inhibit IGF-I actions on sulfate uptake into cartilage). Treatment with GH significantly increased growth rates (P less than 0.001) in the rats, but there was no difference between any of the three GH-treated groups; passive immunization against IGF-I did not diminish the GH-stimulated growth in these rats. Excess antibody could be detected in the plasma of all anti-IGF-I-treated rats at the conclusion of the experiment, and the antibody was capable of sequestering both free and binding protein-bound IGF-I. The absence of even a slight retardation of GH-stimulated growth in the anti-IGF-I-treated rats suggests that circulating IGF-I may not be important in mediating the growth-promoting actions of GH, although the immunoneutralization probably does not affect GH stimulation of tissue IGF-I production.
Improvements in Immunoprecipitation of Specific Messenger RNA (1979)

We have described previously procedures for the isolation of specific mRNA employing immunoprecipitation of polysomes. In spite of our success with ovalbumin mRNA in the chicken oviduct, we have had considerable difficulties in applying these same published techniques to the immunopurification of conalbumin mRNA, despite the fact that the chicken oviduct synthesizes up to 10% of protein as conalbumin. Here we describe a number of modifications and refinements which have proved essential in obtaining intact conalbumin mRNA in high purity and high yields. These refinements include: (a) improved purification of conalbumin in order to remove contaminating proteins that result in impure antibodies; (b) improved isolation of specific conalbumin antibody in high yields; (c) improved methods for reducing contamination by non-specific polysomes; (d) improved techniques for isolation of RNA from immunoprecipitates resulting in less degradation and higher recovery of conalbumin mRNA; (E) improved techniques for efficient translation of conalbumin mRNA involving treatment of the RNA with methylmercury prior to translation. We conclude that problems involved in the immunoprecipitation of different mRNAs may differ, and that various refinements in techniques may be required for obtaining highly purified preparations of intact mRNA in high yields.
Preparation and the Efficacy Evaluation of an Oil-emulsion Inactivated Vaccine Against Novel Duck Reovirus Disease (2012)

Novel Duck Reovirus(NDRV) was the pathogen of duck Hemorrhagic-necrotic hepatitis,which was an epizootic disease of ducklings,has been prevailed in China since 2005.In order to control the disease,one oil-emulsion inactivated vaccine had been developed by NDRV JM85 and the potential protective efficacy was assessed.The study indicated that this vaccine could induce strong immune responses after secondary immunization of sheldrake and the titers of neutralizing antibodies reach the peak at 28d post-immunization.84d post-immunization,the neutralizing antibodies still maintain at a high level.Baby Muscovy ducks born from mothers vaccinated with the oil-emulsion vaccine were protected successfully against NDRV infection,during the first week of life when the risk of this disease was highest.These results showed that the vaccine had a good prospect for against novel duck reovirus disease.
Business object design and implementation workshop (1995)

article Business object design and implementation workshop Share on Author: Jeff Sutherland VMARK Software, 50 Washington Street, Westborough, MA VMARK Software, 50 Washington Street, Westborough, MAView Profile Authors Info & Claims ACM SIGPLAN OOPS MessengerVolume 6Issue 4Oct 1, 1995 pp 170–175https://doi.org/10.1145/260111.260274Online:01 October 1995Publication History 20citation1,231DownloadsMetricsTotal Citations20Total Downloads1,231Last 12 Months60Last 6 weeks11 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Abnormal Changes in NKT Cells, the IGF-1 Axis, and Liver Pathology in an Animal Model of ALS (2011)

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing fatal neurodegenerative disorder characterized by the selective death of motor neurons (MN) in the spinal cord, and is associated with local neuroinflammation. Circulating CD4(+) T cells are required for controlling the local detrimental inflammation in neurodegenerative diseases, and for supporting neuronal survival, including that of MN. T-cell deficiency increases neuronal loss, while boosting T cell levels reduces it. Here, we show that in the mutant superoxide dismutase 1 G93A (mSOD1) mouse model of ALS, the levels of natural killer T (NKT) cells increased dramatically, and T-cell distribution was altered both in lymphoid organs and in the spinal cord relative to wild-type mice. The most significant elevation of NKT cells was observed in the liver, concomitant with organ atrophy. Hepatic expression levels of insulin-like growth factor (IGF)-1 decreased, while the expression of IGF binding protein (IGFBP)-1 was augmented by more than 20-fold in mSOD1 mice relative to wild-type animals. Moreover, hepatic lymphocytes of pre-symptomatic mSOD1 mice were found to secrete significantly higher levels of cytokines when stimulated with an NKT ligand, ex-vivo. Immunomodulation of NKT cells using an analogue of α-galactosyl ceramide (α-GalCer), in a specific regimen, diminished the number of these cells in the periphery, and induced recruitment of T cells into the affected spinal cord, leading to a modest but significant prolongation of life span of mSOD1 mice. These results identify NKT cells as potential players in ALS, and the liver as an additional site of major pathology in this disease, thereby emphasizing that ALS is not only a non-cell autonomous, but a non-tissue autonomous disease, as well. Moreover, the results suggest potential new therapeutic targets such as the liver for immunomodulatory intervention for modifying the disease, in addition to MN-based neuroprotection and systemic treatments aimed at reducing oxidative stress.
A three-valued D-flip-flop and shift register using multiple-junction surface tunnel transistors (2002)

A three-valued D-flip-flop (D-FF) circuit and a two-stage shift register built from InGaAs-based multiple-junction surface tunnel transistors (MJSTT) and Si-based metal-oxide-semiconductor field effect transistors (MOSFET) have been demonstrated. Due to the combination of the MJSTTs latching function and the MOSFETs switching function, the number of devices required for the D-FF circuit was greatly reduced to three from the thirty required for the FET-only circuit.
Comparative Study of the Electrochemical Behaviors for LiCoO2 Electrode Coated with Two Different Al2O3 Coating Layer (2017)

The two samples of coated LiCoO2 electrode with different microstructures of Al2O3 coating layer are prepared. The XRD, SEM and TEM results reveal that both Al2O3 coating layers attached on the surface of LiCoO2 have different uniformity, thickness, morphology and crystallinity. The charge-discharge cycling results show different initial discharge capacity and cycle ability for both Al2O3-coated LiCoO2 samples. The reasons causing electrochemical performance difference are ascribed to some following aspects: the different microstructure of both Al2O3 coating layer poses to the distrinct interface resistance, which may lead to the different transport ability of Li ions as well as electrons through Al2O3 coating layer. And meantime, the electrolyte penetration to the Al2O3 coating is also different, which pose to different side reaction on the interface between cathode and electrolyte for both samples.
A relationship between L-serine degradation and methionine biosynthesis in Escherichia coli K12 (1990)

While wild-type Escherichia coli K12 cannot grow with L-serine as carbon source, two types of mutants with altered methionine metabolism can. The first type, metJ mutants, in which the methionine biosynthetic enzymes are expressed constitutively, are able to grow with L-serine as carbon source. Furthermore, a plasmid carrying the metC gene confers ability to grow on L-serine. These observations suggest that in these mutants, L-serine deamination may be a result of a side-reaction of the metC gene product, cystathionine beta-lyase. The second type is exemplified by two newly isolated strains carrying mutations mapping between 89.6 and 90 min. These mutants use L-serine as carbon source, and also require methionine for growth with glucose at 37 degrees C and above. The phenotypes of the new mutants resemble those of both met and his constitutive mutants in some respects, but have been differentiated from both of them.
Experimental studies of diffraction by photoinduced permanent gratings in nanotube-doped liquid crystals (2002)

We report on our observation of the formation of permanent holographic gratings induced in nematic liquid crystals doped with carbon nanotubes by the simultaneous action of both a spatially modulated light and dc electric field. Properties of these irreversible gratings were investigated with a normally incident laser beam of linear polarization. The polarization dependence of the diffraction intensity of the probe reveals the anisotropic nature of the permanent index gratings.
Laser vaporization of metal films &amp;#8212; Effect of optical interference in underlying dielectric layers (1976)

The interference of incident laser light with light reflected from dielectric interfaces is important in the completeness with which a laser beam vaporizes thin metal films, even though the dielectric layers lie underneath the metal film being vaporized. A structure consisting of titanium-platinum links on a two level dielectric consisting of silicon nitride and silicon dioxide on a silicon substrate was used to demonstrate the effect. The resistance of laser vaporized titanium-platinum links varied by more than seven orders of magnitude as the thickness of the silicon dioxide, the lower dielectric, was varied. The thicknesses of underlying dielectric layers are, therefore, parameters which must be taken into account when using a laser beam to produce high resistance open circuits in metal films.
Unit-delay focusing architecture and integrated-circuit implementation for high-frequency ultrasound (2003)

High-frequency ultrasound (above 10 MHz) has been used successfully in many medical applications, including eye, skin, gastrointestinal, intravascular, and Doppler flow imaging. Most of these applications use single-element transducers, thereby imposing a tradeoff between resolution and depth of field. Fabrication difficulties and the need for high-speed electronic beamformers have prevented widespread use of arrays at high frequencies. In this paper, a unit-delay focusing architecture suitable for use with high-frequency ultrasound annular arrays is described. It uses a collection of identical, active delay cells that may be simultaneously varied to accomplish focusing. Results are presented for an analog integrated circuit intended for use with a five-element, 50-MHz planar annular array. Focusing is possible over an axial range for which the ratio of maximum to minimum f-number is 2.1. Unit-delay architectures also are described for curved annular arrays and linear arrays.
[Experience of preservation remission in inflammatory bowel diseases]. (2011)

The results of hyperbaric oxygenation and correction (HOC) method of intestinal microflora by liquid sinbiotic biocomplex "Normoflorin" at the second phase of the treatment of IBD under conservation of remission. The unresolved issues of minimization of adverse events and improvement the quality of life of patients with IBD, reveal the actuality of the problem. The results of joint usage of the method of hyperbaric oxygenation and correction method with liquid intestinal microflora synbiotic biocomplex "Normofloriny", allow a better correction mikrobiocenozis of the bowel. Biocomplexes "Normofloriny" and the HBO method should include treatment programs for patients with IBD during the maintenance of remission.
Face photo recognition using sketch (2003)

Automatic retrieval of face images from police mug-shot databases is critically important for law enforcement agencies. It can help investigators to locate or narrow down potential suspects efficiently. However, in many cases, the photo image of a suspect is not available and the best substitute is often a sketch drawing based on the recollection of an eyewitness. We present a novel photo retrieval system using face sketches. By transforming a photo image into a sketch, we reduce the difference between photo and sketch significantly, thus allowing effective matching between the two. Experiments over a data set containing 188 people clearly demonstrate the efficacy of the algorithm.
Experimental Analysis of the Mouse Submaxillary Salivary Gland in Relationship to Its Nerve-Growth Factor Content (1962)

It has been reported in previous work that the mouse submaxillary salivary glands contain a potent nerve-growth factor (NGF) that promotes the differentiation and growth of the sympathetic ganglia. It also has been reported that this factor is a protein that is present in higher concentration in the adult male than in the adult female gland. In the present paper the sexual dimorphism of the mouse submaxillary salivary gland was investigated with regard to the NGF content. Injections of testosterone in female mice called forth a marked increase of this factor. Conversely, castration of adult male mice resulted in a sharp decrease of the NGF. The relationship of the salivary protease to the NGF, both located in the tubular components of the gland, was investigated after ligature of the excretory duct of the gland. The possible role of the submaxillary salivary gland in the production of the NGF is discussed in the light of the present findings.
Simulation of prompt gamma-ray emission during proton radiotherapy (2012)

The measurement of prompt gamma rays emitted from proton-induced nuclear reactions has been proposed as a method to verify in vivo the range of a clinical proton radiotherapy beam. A good understanding of the prompt gamma-ray emission during proton therapy is key to develop a clinically feasible technique, as it can facilitate accurate simulations and uncertainty analysis of gamma detector designs. Also, the gamma production cross-sections may be incorporated as prior knowledge in the reconstruction of the proton range from the measurements. In this work, we performed simulations of proton-induced nuclear reactions with the main elements of human tissue, carbon-12, oxygen-16 and nitrogen-14, using the nuclear reaction models of the GEANT4 and MCNP6 Monte Carlo codes and the dedicated nuclear reaction codes TALYS and EMPIRE. For each code, we made an effort to optimize the input parameters and model selection. The results of the models were compared to available experimental data of discrete gamma line cross-sections. Overall, the dedicated nuclear reaction codes reproduced the experimental data more consistently, while the Monte Carlo codes showed larger discrepancies for a number of gamma lines. The model differences lead to a variation of the total gamma production near the end of the proton range by a factor of about 2. These results indicate a need for additional theoretical and experimental study of proton-induced gamma emission in human tissue.
Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization (2021)

The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches. Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.
Exchange-biased spin-valves for magnetic storage (1996)

An overview is given of the material properties of exchange-biased spin-valves. More specifically, we discuss the microstructure and magnetic properties of these materials as relevant for (future) industrial application in magnetoresistive read heads for rigid disk and tape recording and Magnetic Random Access Memory (MRAM) devices.