gebhart/patrepeval huggingface dataset:
Comment on “Fabrication of a Molecular Self-Assembled Monolayer Diode Using Nanoimprint Lithography” (2004)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTComment on "Fabrication of a Molecular Self-Assembled Monolayer Diode Using Nanoimprint Lithography"Wenyong Wang, Takhee Lee, and Mark A. ReedView Author Information Departments of Electrical Engineering, Applied Physics, and Physics, Yale University, P.O. Box 208284, New Haven, Connecticut 06520 Cite this: Nano Letters 2004, 4, 3, 533Publication Date (Web):February 14, 2004Publication History Received29 December 2003Published online14 February 2004Published inissue 1 March 2004https://pubs.acs.org/doi/10.1021/nl0352503https://doi.org/10.1021/nl0352503rapid-communicationACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views260Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Manufacturing,Self-assembled monolayers,Thermodynamic modeling,Tunneling Get e-Alerts
Branchy alumina nanotubes (2002)

Branchy alumina nanotubes (bANTs) have been shown to exist in aluminum oxide. Electron-beam evaporated 400 nm Al film on Si substrate is stepwise anodized in dilute sulfuric acid under the constant dc voltage 40 V at 10.0 °C. This electrochemical-anodizing route resulted in the formation of individual bANTs. Transmission electron microscopy showed that the length of the bANTs was around 450 nm, and the inner diameter was around 10–20 nm. We deduced that the bANTs, the completely detached multibranchy cells of anodic porous alumina (APA) film, should be evolved from the stagnant cells of the APA mother film. The bANTs may be used as templates in fabrication of individual branchy nanoscale cables, jacks, and heterojunctions. The proposed formation mechanisms of the bANTs and the stagnant cells should give some insights into the long-standing problem of APA film, i.e., the self-ordering mechanism of the cells arrangement in porous anodization of aluminum.
Development and validation of Transfusion Risk Understanding Scoring Tool (TRUST) to stratify cardiac surgery patients according to their blood transfusion needs (2006)

Based on the standards of measurement in clinical research, a valid clinical tool was developed for predicting the need for blood transfusion in patients undergoing cardiac surgery. The clinical tool was internally and externally validated, and the results suggest that it should perform well at other institutions.
Selected-area Deposition Of Multiple Active Films For Conductometric Microsensor Arrays (2005)

Abstract A new generation of planar conductometric gas sensors is being developed which combines active semiconducting oxide films with Si-micromachined ‘micro-hotplate’ array structures. These devices are tailored for a variety of applications by tuning both the composition of multiple types of active films and the temperature cycles programmed for individual elements within an array. In this paper we described and demonstrate the approach, and present results for, a chemical vapor deposition (CVD)-based self-lithographic microfabrication method. This method is being examined as a highly efficient and compatible means of depositing oxide films and low-coverage catalytic metal overlayers on the microsensor elements of micro-hotplate arrays. Real-time monitoring of the film growth processe is provided by conductance measurements, and surveys of processing/property relationships can be performed in a very effective manner to determine optimal fabrication methods for multiple-active material arrays.
Parallel investments in multiple call and put options for the tracking of desired profit profiles (2017)

A hierarchical algorithm is presented for optimally and automatically combining various option investments to cost-efficiently realize a desired profit-vs.-underlying-price profile (profit profile). The algorithm assumes that a user-defined reference shape is defined and a set of plain vanilla options in which long and short investment positions can be taken are given. Within the presented framework, the desired profit profile can be of arbitrary piecewise-affine (PWA) shape. Depending on future underlying price predictions, it typically represents a bearish or bullish market outlook, or displays bi-modal shape for conditional market outlooks. The method provides a tool for portfolio optimization that is flexible enough to trade off different user-preferences such as exploiting on conditional market outlooks, realizing leverage, and most notably guaranteeing predictable worst-case losses for risk-minimization. The framework can easily be extended to account for different derivative contracts such as exotic options.
Chromatographic Analysis of Compounds of Pharmaceutical Interest (2001)

A set of 17,600 samples belonging to our compound collection is selectively examined by liquid chromatography with UV, evaporative light scattering, and mass spectrometric detection methods. At least 70% of this set consists of pure samples with the expected structures. Subsequent studies by flow injection mass spectrometry show that this value is a conservative estimate and that the actual percentage of pure and correct compounds is close to 80%. Because this is the first time that sample quality information becomes available on such a large scale for the compound collection, it offers an opportunity to perform chemi-informatic studies for which structural integrity is essential. Results of these studies can be used to improve the selection of compounds for screening and evaluate the quality of compounds from particular sources.
Genes misregulated in<i>C. elegans</i>deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes (2007)

We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched for genes regulated by Dicer. Comparison of all three microarray data sets indicates the majority of Dicer-regulated genes are not dependent on RDE-4 or RDE-1, including the X-linked genes. However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes.
Design of remote and wireless,switch intelligent control light (2011)

In order to control the light of indoor lamp by wireless and remote means,a project to integrate wireless communication and ethernet access technology was presented.In this system,the light sensors acquires light data and transmits it to CPU,the CPU outputs PWM waveforms to control the angle of turning on silicon to adjust light intensity;and RF technology is used in wireless control;the function of remote controlling was realized through Ethernet interface chip-ENC28J60.Otherwise,the hardware and software structure of the system had been introduced;the specific application of this project was expounded.The experiment proved that the project can meet designer's need.
Biobased Nano Porous Active Carbon Fibers for High-Performance Supercapacitors (2016)

Activated carbon fibers (ACFs) with different pore structure have been prepared from wood sawdust using the KOH activation method. A study was conducted to examine the influence of the activation parameters (temperature, alkali/carbon ratio, and time) on the morphology and structure of the as-prepared ACFs developed in the process of pore generation and evolution. Activation temperature was very essential for the formation of utramicropores (<0.6 nm), which greatly contributed to the electric double layer capacitance. The significance of metallic potassium vapor evolved when the temperature was above 800 °C, since the generation of 0.8- and 1.1 nm micropores cannot be ignored. When the the KOH/fiber ratio was increased and the activation time was prolonged, to some extent, the micropores were enlarged to small mesopores within 2-5 nm. The sample with the optimal condition exhibited the highest specific capacitance (225 F g(-1) at a current density of 0.5 A g(-1)). Its ability to retain capacitance corresponding to 10 A g(-1) and 6 M KOH was 85.3%, demonstrating a good rate capability. With 10 000 charge-discharge cycles at 3 A g(-1), the supercapacitor kept 94.2% capacity, showing outstanding electrochemical performance as promising electrode material.
Towards a Global Sustainability Knowledge Network (2003)

Sustainability is central to engineering practice in the 21st century and therefore an essential element of engineering education. For practitioners, researchers and students relevant information on sustainability is dispersed or difficult to locate as it is generated by experts in many discipline areas not just in the traditional engineering ones. Sustainability is multi-disciplinary in nature. To meet these needs a web portal, the Sustainability Knowledge Network (SKN), has been launched, building upon the foundation of the successful Australasian Virtual Engineering Library. The SKN contains over 4000 resources and has other value adding services for its users, and these are being further developed. This network is pioneering a much broader vision - the global Virtual Environment and Sustainable Systems Engineering Library (VESSEL). AVEL and AVEL-SKN were developed by a national consortium of partner organisations including universities, research organisations and engineering institutions, that were geographically dispersed. The successful development of these resources involved the close collaboration of engineers and librarians working as a distributed virtual team.
Genomic Exploration of the Hemiascomycetous Yeasts: 13. <i>Pichia angusta</i> (2000)

As part of a comparative genomics project on 13 hemiascomycetous yeasts, the Pichia angusta type strain was studied using a partial random sequencing strategy. With coverage of 0.5 genome equivalents, about 2500 novel protein-coding genes were identified, probably corresponding to more than half of the P. angusta protein-coding genes, 6% of which do not have homologs in Saccharomyces cerevisiae. Some of them contain one or two introns, on average three times shorter than those in S. cerevisiae. We also identified 28 tRNA genes, a few retrotransposons similar to Ty5 of S. cerevisiae, solo long terminal repeats, the whole ribosomal DNA cluster, and segments of mitochondrial DNA. The P. angusta sequences were deposited in EMBL under the accession numbers AL430961 to AL436044.
Placental and lactational transfer of ochratoxin A in rats (1998)

The placental and lactational transfer of ochratoxin A (OA) was investigated in a cross-fostering study in rats. Dams were given 50 microg OA(-1) kg body weight by gastric intubations 5 times a week for 2 weeks before mating, during gestation and then 7 days a week during lactation. Neonates from OA-treated dams were cross-fostered at birth to control dams treated with only vehicle. In the same way, neonates from control dams were cross-fostered to OA-treated dams. Treatment with OA did not result in any effects on birth weight or growth development of the pups during the first 21 days of life. There were no effects on milk quality as measured by milk lipids, protein or lactose concentrations, or on milk production, assessed by the mammary gland content of RNA and DNA. A mean milk:blood ratio of approximately 0.6 was found. The dose of OA from milk to the suckling pup at 14 days of age can be calculated to about 50 microg kg(-1) body weight(-1) day, which is similar to the dose given to the dams. Pups exposed to OA only via milk had blood and kidney levels of OA approximately 3 times higher than their dams, indicating a high absorption and/or a low excretion of OA in the sucklings. At 14 days of age the highest blood and kidney levels of OA were found in offspring exposed both via placenta and milk, with the highest contribution from milk. Offspring exposed only via milk had about 4-5 times higher levels of OA in blood and kidney compared to offspring exposed only via placenta. As milk could be a significant source of OA exposure in newborns, adverse health effects resulting from postnatal exposure should be studied and evaluated in the risk assessment of OA.
The Transition from Church Growth to Church Health (2005)

When I have taught Church Growth principles I have found it helpful to look at Acts 2:41-47 and the variety of growth types indicated in these verses. You will find: Growing up in verse 42, individuals growing into a mature relationship with God; Growing together in verse 44, in great generosity and spiritual gifts; Growing out in verse 47a, into the community; Growing more in verse 47b, as the numbers increase. The problem has been that Church Growth thinking has been caricatured as relating only to the last of these, although a careful reading of the Church Growth books shows that there always was far more than this. I think the problem is that many have been threatened by the thinking, which says that numerical growth should take place and that God calls us to fruitfulness, especially in Europe where the church has declined for more than 50 years. However, anyone who only concentrates on ‘bums on seats’ is missing an important part of God’s purposes for his kingdom. He desires growth in every dimension, not just numerical!
Automatic focus algorithms for TDI X-Ray image reconstruction (2012)

Abstract. In food industry, most products are checked by X-rays for contaminations. These X-ray machines continuously scan the product passing through. To minimize the required X-ray power, a Time, Delay and Integration (TDI) CCD-sensor is used to capture the image. While the product moves across the sensor area, the X-ray angle changes during the pass. As a countermeasure, adjusting the sensor shift speed on a single focal plane of the product can be selected. However, the changing angle result in a blurred image in dependance to the thickness of the product. This so-called ''laminographic effect'' can be compensated individually for one plane by inverse filtering. As the plane of contamination is unknown, the blurred image will be inversely filtered for different planes, but only one of these images shows the correctly focussed object. If the correct image can be found, the plane containing the contamination is identified. In this contribution we demonstrate how the correctly focussed images can be found by analyzing the images of all planes. Different characteristics for correctly and incorrectly focussed planes like sharpness, number of objects and edges are investigated by using image processing algorithms.
Biochemical properties of recombinant human <i>β</i>-glucuronidase synthesized in baby hamster kidney cells (1994)

The cDNA sequence encoding human beta-glucuronidase [Oshima, Kyle, Miller, Hoffmann, Powell, Grubb, Sly, Troplak, Guise and Gravel (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 685-689] was expressed in baby hamster kidney (BHK) cells. After purification from the culture supernatant in one step by use of immunoaffinity chromatography, the biochemical properties of the enzyme were examined. With a pH optimum of 4.0, a Km of 1.3 mM and thermal stability up to 68 degrees C, this protein has characteristics very similar to those described for beta-glucuronidase from human placenta [Brot, Bell and Sly (1978) Biochemistry 17, 385-391. However, the recombinant product has several structural properties not previously reported for beta-glucuronidase isolated from natural sources. First, recombinant beta-glucuronidase is synthesized as a tetramer consisting of two disulphide-linked dimers. As can be inferred from the cDNA sequence, the enzyme possesses five cysteine residues after cleavage of the signal peptide. By introducing a C-terminal truncation, we eliminated the last cysteine at position 644. In the mutant, covalent linkage between two monomers is no longer observed, indicating that Cys-644 is involved in intermolecular disulphide-bond formation. The functional role of the disulphide bond remains elusive, as it was shown that (i) intracellular transport of the mutant is not impaired and (ii) it is still able to form an enzymically active tetramer. A second feature that has not previously been observed for beta-glucuronidase from any origin is the existence of two enzymically active species for recombinant beta-glucuronidase, when examined by gel filtration on a TSK 3000 column. With apparent molecular masses of 380 kDa and 190 kDa we propose that they represent tetramers and dimers respectively. Partial N-terminal sequencing and electrophoresis under denaturing conditions revealed that the dimers consist of subunits that have been proteolytically processed at their C-terminus losing 3-4 kDa in peptide mass. Controlled proteolysis demonstrates that the enzyme's overall protein backbone as well as its activity are resistant to a number of proteases. Only the C-terminal portion is susceptible to protease action, and the disulphide-linked form is readily converted into non-disulphide-bonded subunits. Pulse-chase analysis shows that human beta-glucuronidase remaining intracellular in BHK cells after synthesis undergoes a similar proteolytic processing event, i.e. a reduction in mass of 3-4 kDa.(ABSTRACT TRUNCATED AT 400 WORDS)
Mining Molecular Datasets on Symmetric Multiprocessor Systems (2006)

Although in the last few years about a dozen sophisticated algorithms for mining frequent fragments in molecular databases have been proposed, searching big databases with 100,000 compounds and more is still a time-consuming process. Even the currently fastest algorithms like gSpan, FFSM, Gaston, or MoFa require hours to complete their tasks. This paper presents thread-based parallel versions of MoFa [5] and gSpan [26] that achieve speedups up to 11 on a shared-memory SMP system using 12 processors. We discuss the design space of the parallelization, the results, and the obstacles that are caused by the irregular search space and by the current state of Java technology.
Les néologismes dans les idiomes gabonais. (1933)

Walker A. Les néologismes dans les idiomes gabonais.. In: Journal de la Société des Africanistes, 1933, tome 3, fascicule 2. pp. 305-314.
DNA-damaging activity of patulin in Escherichia coli (1986)

At a concentration of 10 micrograms/ml, patulin caused single-strand DNA breaks in living cells of Escherichia coli. At 50 micrograms/ml, double-strand breaks were observed also. Single-strand breaks were repaired in the presence of 10 micrograms of patulin per ml within 90 min when the cells were incubated at 37 degrees C in M9-salts solution without a carbon source. The same concentration also induced temperature-sensitive lambda prophage and a prophage of Bacillus megaterium. When an in vitro system with permeabilized Escherichia coli cells was used, patulin at 10 micrograms/ml induced DNA repair synthesis and inhibited DNA replication. The in vivo occurrence of DNA strand breaks and DNA repair correlated with the in vitro induction of repair synthesis. In vitro the RNA synthesis was less affected, and overall protein synthesis was not inhibited at 10 micrograms/ml. Only at higher concentrations (250 to 500 micrograms/ml) was inhibition of in vitro protein synthesis observed. Thus, patulin must be regarded as a mycotoxin with selective DNA-damaging activity.
Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro (2003)

We designed, synthesized, and identified UIC-94017 (TMC114), a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing a 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane (bis-THF) and a sulfonamide isostere which is extremely potent against laboratory HIV-1 strains and primary clinical isolates (50% inhibitory concentration [IC(50)], approximately 0.003 micro M; IC(90), approximately 0.009 micro M) with minimal cytotoxicity (50% cytotoxic concentration for CD4(+) MT-2 cells, 74 micro M). UIC-94017 blocked the infectivity and replication of each of HIV-1(NL4-3) variants exposed to and selected for resistance to saquinavir, indinavir, nelfinavir, or ritonavir at concentrations up to 5 micro M (IC(50)s, 0.003 to 0.029 micro M), although it was less active against HIV-1(NL4-3) variants selected for resistance to amprenavir (IC(50), 0.22 micro M). UIC-94017 was also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients who had no response to existing antiviral regimens after having received a variety of antiviral agents. Structural analyses revealed that the close contact of UIC-94017 with the main chains of the protease active-site amino acids (Asp-29 and Asp-30) is important for its potency and wide spectrum of activity against multi-PI-resistant HIV-1 variants. Considering the favorable pharmacokinetics of UIC-94017 when administered with ritonavir, the present data warrant that UIC-94017 be further developed as a potential therapeutic agent for the treatment of primary and multi-PI-resistant HIV-1 infections.
The Fiduciary Principle in Private and Public Law (2009)

Abstract This chapter discusses fiduciary principle in private and public law. Topics covered include transparency and accountability as fiduciary responsibilities, finding solutions to fiduciary breach, the threat posed by systemic corruption to the fiduciary principle, and rules' predominance over standards and criminalization in ethics law.
Three-dimensional anisotropies induced by light in thin polymer films (2003)

The three-dimensional structure of thin anisotropic polymer films is of great importance for many applications, such as display technology and optical data storage. We developed different methods for the accurate determination of the in-plane and the out-of-plane anisotropy of thin polymer films. The anisotropic properties are generated or modified by irradiation with polarized light at room temperature and subsequent thermal development of the liquid crystalline polymers. For the characterisation of thin films different ellipsometric methods and absorbance measurements were developed and for thick films the prism coupling method was used. The three-dimensional structure of the films and the resulting optical properties are strongly dependent on thickness and preparation of the films. The photoinduced order is generated by the photoorientation of azobenzene containing side chain polymers. This order is changed by annealing of the films in the liquid crystalline phase of the polymers. For thinner spin coated films the order after annealing is almost a prolate in-plane order. This should be caused by the initial in-plane order induced by the spin coating process. In the case of thicker films the order after annealing is homeotropic due to the interfacial order. Under certain conditions even an oblate order was found after annealing.