gebhart/patrepeval huggingface dataset:
Acetylative Desulfation of Carbohydrate Acid Sulfates<sup>1</sup> (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcetylative Desulfation of Carbohydrate Acid Sulfates1M. L. Wolfrom and Rex MontgomeryCite this: J. Am. Chem. Soc. 1950, 72, 7, 2859–2861Publication Date (Print):July 1, 1950Publication History Published online1 May 2002Published inissue 1 July 1950https://pubs.acs.org/doi/10.1021/ja01163a011https://doi.org/10.1021/ja01163a011research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the Effectiveness of Visible Watermarks (2017)

Visible watermarking is a widely-used technique for marking and protecting copyrights of many millions of images on the web, yet it suffers from an inherent security flaw-watermarks are typically added in a consistent manner to many images. We show that this consistency allows to automatically estimate the watermark and recover the original images with high accuracy. Specifically, we present a generalized multi-image matting algorithm that takes a watermarked image collection as input and automatically estimates the foreground (watermark), its alpha matte, and the background (original) images. Since such an attack relies on the consistency of watermarks across image collection, we explore and evaluate how it is affected by various types of inconsistencies in the watermark embedding that could potentially be used to make watermarking more secured. We demonstrate the algorithm on stock imagery available on the web, and provide extensive quantitative analysis on synthetic watermarked data. A key takeaway message of this paper is that visible watermarks should be designed to not only be robust against removal from a single image, but to be more resistant to mass-scale removal from image collections as well.
HIV infection and sexually transmitted diseases (1991)

This chapter examines the case for assigning high priorities in developing countries to prevention of sexually transmitted diseases (STDs) both the diseases and HIV/AIDS. The distinctive epidemiology and prevalence of the 20 classic STDs and AIDS is that while they may be bacteria virus protozoa fungi or ectoparasites they are all specifically adapted to the genital tract and transmitted primarily by sexual intercourse. The highest rates of infection are in young urban socially mobile or unemployed adults aged 15-35. The STDs are highly communicable with a high reproduction such that prevention of one case had in preventing subsequent cases. Sexual activity can be subdivided into a of highly sexually active individuals (about 2% of the population 10 times as sexually active with new randomly selected partners every 5 days) and non-core group. The epidemiology i.e prevalence complications and sequelae of classic STDs and AIDS in developing countries is reviewed. The public health impact is discussed in terms of years of healthy life lost per case in comparison to other major diseases. In a typical African city 22% of total disease burden is due to STDs and HIV. The static dynamic short and long term and gender-specific burdens and demographic impact of these diseases are derived theoretically. One prediction by Bongaarts model projects that the population growth rate will fall from 3% to 1.9% as a result of AIDS in 25 years. Examples of gender-specific burdens are infertility and divorce of affected women and discontinuation of contraception because of blaming genital discharge on contraceptives. Principles of primary prevention of STD are discussed under the topics of static and dynamic benefits and costs of averting a case sexual transmission vertical transmission transfusion and skin-piercing transmission. A policy of targeting by one-time intervention at the core averts 10 times as many cases as would have been averted by a policy directed at the non-core. Mandatory prevention such as detaining core individuals is best suited for emergency control of politically unpopular behavior. Voluntary prevention can better be achieved by changing prices e.g. improving the marriage education and job opportunities for women who would otherwise engage in prostitution as has the enterprise zone in northern Mexico. The goals principles costs future developments priorities and potential benefits of case management of STDs are reviewed. The control and management of STDs when the core group is targeted is highly cost-effective compared to non-targeting. Appendices include health impact of individual STDs and clinical management of STD syndromes.
A General Synthetic Route to Mixed NHC–Phosphane Palladium(0) Complexes (NHC=N‐Heterocyclic Carbene) (2008)

Mixed NHC-phosphane palladium(0) complexes [(NHC)Pd(PR(3))] (NHC: N-heterocyclic carbene) are synthesized directly from commercially available reagents, with the possibility to tune the nature of both the NHC and the phosphane. Reaction of [(NHC)Pd(allyl)Cl] (palladium source) and PR(3), in the presence of a base afforded, in isopropanol, [(NHC)Pd(PR(3))] in good yields. We found that the nature of the solvent played a key role in the efficient reduction of the Pd(II) precursor to Pd(0). Supported by experimental evidence we propose that the reduction step is driven by the isopropoxide anion formed in situ from isopropanol and a base. Detection of acetone in the reaction mixture confirms that the isopropoxide anion acts as the reducing agent. Moreover, different bases proved efficient for the reaction. The structures of the complexes were unambiguously confirmed by X-ray analysis. Exposure of these complexes to air does not lead to decomposition, but to the oxo-complex [(NHC)Pd(PR(3))(O(2))], which is stable both in the solid state and in solution.
Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity (1988)

Abnormal functional activity induces long-lasting physiological alterations in neural pathways that may play a role in the development of epilepsy. The cellular mechanisms of these alterations are not well understood. One hypothesis is that abnormal activity causes structural reorganization of neural pathways and promotes epileptogenesis. This report provides morphological evidence that synchronous perforant path activation and kindling of limbic pathways induce axonal growth and synaptic reorganization in the hippocampus, in the absence of overt morphological damage. The results show a previously unrecognized anatomic plasticity associated with synchronous activity and development of epileptic seizures in neural pathways.
On the capacity of a GSM frequency hopping network with intelligent underlay-overlay (2002)

This paper describes a method to increase the capacity of a digital cellular network, like GSM, without having to increase the number of available frequencies or base stations. The idea is to split the frequency spectrum into two bands. One consisting of frequencies that can only be used when a high C/I ratio is ensured, the super frequencies, and the other consisting of frequencies that can be used throughout the whole cell, the regular frequencies. The minimum frequency reuse distance of the super frequencies can therefore be smaller than the reuse distance of the regular layer frequencies. By combining this reuse partitioning with frequency hopping, an increase in the network capacity in terms of carried traffic per cell is achieved. Simulations have indicated that for slow moving mobiles a gain of approximately 35% is achieved by this new feature when compared with a frequency hopping network. For faster moving mobiles the simulated gain is lower, approximately 26%. Modifications are proposed to optimise the simulated algorithms, to improve the capacity in terms of carried traffic per cell even further.
Dual Purpose Desktop Machine - 3D Printer and CNC Milling (2014)

Because of the increase in demand of machines for personal use, and due to the fact that machines with combined processes are not yet sold in this niche market. Many consumers, especially in industry, possess manufacturing processes on completely different machines, and few attempt to retrofit one for the other process. The dual-purpose desktop machine is the result of combining 3D printing and CNC milling, two popular processes, in a useful DIY format for in-home manufacturing. With the popularity of people making their own parts at home and the ease of buying components and machines in today’s world, even those without experience in these processes can jump in and learn about personal manufacturing. Important aspects considered were the common components of 3D printing and milling machines, and the crucial acquisition of these components in a form that would allow both processes to work. The machine will be an important learning tool for classrooms and a resource to expose students to manufacturing technologies. It also serves as a level of comparison to existing, available products on the market. Lastly, the machine fits with in-home manufacturing by having a smaller footprint, easy operation, and interchangeability of the processes.
Lunar sourcebook : a user's guide to the moon (1991)

The present status of lunar knowledge based on U.S. and USSR lunar missions and the continuing analysis of lunar samples and data is reviewed. Particular attention given to exploration, samples, and recent concepts of the moon; the lunar environment; lunar surface processes; the lunar minerals, rocks, and regolith; chemical elements in the moon; physical properties of the lunar surface; and global and regional data about the moon.
Nanocomputing by field-coupled nanomagnets (2002)

Demonstrates through simulations the feasibility of using magnetically coupled nanometer-scale ferromagnetic dots for digital information processing. Microelectronic circuits provide the input and output of the magnetic nanostructure, but the signal is processed via magnetic dot-dot interactions. Logic functions can be defined by the proper placements of dots. We introduce a SPICE macromodel of interacting nanomagnets and use this tool to design and simulate the proposed nanomagnet logic units. This SPICE model allows us to simulate such magnetic information processing devices within the same framework as conventional electronic circuits.
Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. (1998)

Cells within solid tumors are known to exist in a microenvironment that may be acidic and depend on membrane-based mechanisms (Na+/H+ antiport and Na+-dependent Cl-/HCO3- exchanger) that regulate intracellular pH (pHi). We have used the fluorescent pH indicator 2',7'-bis-(2-carboxyethyl) 5 (and 6)-carboxyfluorescein and flow cytometry to study the distribution of pHi and the activity of these pHi-regulating mechanisms among populations of murine mammary sarcoma (EMT6), human breast cancer (MCF-7), and Chinese hamster ovary cells exposed to different levels of extracellular pH (pHe). Cells were exposed to Na+ buffer in the presence or absence of HCO3- and of 5-(N-ethyl-N-isopropyl)-amiloride (a potent inhibitor of the Na+/H+ antiport) to determine the relative importance of each exchanger in the regulation of pHi. Our results indicate that: (a) the distribution of pHi at any value of pHe is broader than can be accounted for by machine noise; (b) cells maintain levels of pHi that are higher than pHe under acidic conditions; (c) the distribution of pHi is narrower when the Na+-dependent Cl-/HCO3- exchanger is active; and (d) populations that are derived from selected cells with values of pHi at lower and higher ends of the pHi distribution generate pHi distributions that are similar to those of controls, suggesting a stochastic variation in the activity of membrane-based mechanisms that regulate pHi. Our data suggest that the Na+-dependent Cl-/HCO3- exchanger is the dominant mechanism for regulation of pHi under moderately acidic conditions such as may occur in the microenvironment of solid tumors.
Mathematical Modeling of Tumor Growth and Metastatic Spreading: Validation in Tumor-Bearing Mice (2014)

Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreading might estimate the risk of metastasis when no clinical evidence is available. In this study, we adapted a top-down model to make such estimates. The model was constituted by a transport equation describing metastatic growth and endowed with a boundary condition for metastatic emission. Model predictions were compared with experimental results from orthotopic breast tumor xenograft experiments conducted in Nod/Scidγ mice. Primary tumor growth, metastatic spread and growth were monitored by 3D bioluminescence tomography. A tailored computational approach allowed the use of Monolix software for mixed-effects modeling with a partial differential equation model. Primary tumor growth was described best by Bertalanffy, West, and Gompertz models, which involve an initial exponential growth phase. All other tested models were rejected. The best metastatic model involved two parameters describing metastatic spreading and growth, respectively. Visual predictive check, analysis of residuals, and a bootstrap study validated the model. Coefficients of determination were [Formula: see text] for primary tumor growth and [Formula: see text] for metastatic growth. The data-based model development revealed several biologically significant findings. First, information on both growth and spreading can be obtained from measures of total metastatic burden. Second, the postulated link between primary tumor size and emission rate is validated. Finally, fast growing peritoneal metastases can only be described by such a complex partial differential equation model and not by ordinary differential equation models. This work advances efforts to predict metastatic spreading during the earliest stages of cancer.
Correction of the temperature induced error of the illumination source in a time-of-flight distance measurement setup (2013)

A systematic investigation of the combination of a reference path and a reference pixel as correction method for a systematic error induced by the light source of a time-of-flight (TOF) distance measurement sensor is presented. A change of the bandwidth of the light source, e.g. caused by drifting temperature of the used LEDs results in a bandwidth dependent distance error. The presented method allows reducing this error over a large operating range by ~97 %, i.e. to 3 %.
JITDefender: A Defense against JIT Spraying Attacks (2011)

JIT spraying is a new code-reuse technique to attack virtual machines based on JIT (Just-in-time) compilation. It has proven to be capable of circumventing the defenses such as data execution prevention (DEP) and address space layout randomization(ASLR), which are effective for preventing the traditional code injection attacks. In this paper, we describe JITDefender, an enhancement of standard JIT-based VMs, which can prevent the attacker from executing arbitrary JIT compiled code on the VM. Thereby JITDefender can block JIT spraying attacks. We prove the effectiveness of JITDefender by demonstrating that it can successfully prevent existing JIT spraying exploits. JITDefender reports no false positives when run over benign actionscript/javascript programs. In addition, we show that the performance overhead of JITDefender is low.
SNR-based multipath error correction for GPS differential phase (1996)

Carrier phase multipath is currently the limiting error source for high precision Global Positioning System (GPS) applications such as attitude determination and short baseline surveying. Multipath is the corruption of the direct GPS signal by one or more signals reflected from the local surroundings. Multipath reflections affect both the carrier phase measured by the receiver and signal-to-noise ratio (SNR). A technique is described which uses the SNR information to correct multipath errors in differential phase observations. The potential of the technique to reduce multipath to almost the level of receiver noise was demonstrated in simulations. The effectiveness on real data was demonstrated with controlled static experiments. Small errors remained, predominantly from high frequency multipath. The low frequency multipath was virtually eliminated. The remaining high frequency receiver noise can be easily removed by smoothing or Kalman filtering.
Monoclonal antibody to chicken fetal antigen on Marek's disease lymphoblastoid cell line MDCC-MSB1. (1986)

A monoclonal antibody (2H3) to chicken fetal antigen (CFA) expressed on the cell surface of the Marek's disease lymphoblastoid cell line MDCC-MSB1 was generated. 2H3 reacted specifically with various cells from chicken embryos, especially with fetal red blood cells, fetal bursa-derived lymphocytes, fetal liver cells, and embryo fibroblasts but not with fetal peripheral blood lymphocytes. 2H3 reacted also with all lymphoblastoid cell line cells tested: Marek's disease, avian leukosis, and reticuloendotheliosis line cells. On the basis of 2H3 specificity, CFA detected by 2H3 seemed to be similar to chicken fetal red blood cell antigen previously reported, but not to chicken alpha-fetoprotein. A transient increase of reactivities with 2H3 was observed in lymphocytes prepared from thymus, spleen, and bursa of chickens inoculated with Marek's disease virus or herpesvirus of turkeys from 7 to 21 days postinoculation. The average percentage of CFA-positive cells in lymphoid cells from Marek's disease virus-infected chickens at the peaks was higher than that of the cells in Marek's disease tumor cells from 146- and 156-day-old chickens in the field. The results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting analysis revealed that the monoclonal 2H3 is recognized a Mr 50,000 oncodevelopmental cell surface antigen present on MDCC-MSB1 cells. The possible differences between CFA detected by 2H3 and chicken fetal red blood cell antigen expressed on normal chicken fetal erythrocytes are discussed.
Characterization of<i>Schizosaccharomyces pombe</i>Malate Permease by Expression in<i>Saccharomyces cerevisiae</i> (2001)

In Saccharomyces cerevisiae, L-malic acid transport is not carrier mediated and is limited to slow, simple diffusion of the undissociated acid. Expression in S. cerevisiae of the MAE1 gene, encoding Schizosaccharomyces pombe malate permease, markedly increased L-malic acid uptake in this yeast. In this strain, at pH 3.5 (encountered in industrial processes), L-malic acid uptake involves Mae1p-mediated transport of the monoanionic form of the acid (apparent kinetic parameters: Vmax = 8.7 nmol/mg/min; Km = 1.6 mM) and some simple diffusion of the undissociated L-malic acid (Kd = 0.057 min(-1)). As total L-malic acid transport involved only low levels of diffusion, the Mae1p permease was further characterized in the recombinant strain. L-Malic acid transport was reversible and accumulative and depended on both the transmembrane gradient of the monoanionic acid form and the DeltapH component of the proton motive force. Dicarboxylic acids with stearic occupation closely related to L-malic acid, such as maleic, oxaloacetic, malonic, succinic and fumaric acids, inhibited L-malic acid uptake, suggesting that these compounds use the same carrier. We found that increasing external pH directly inhibited malate uptake, resulting in a lower initial rate of uptake and a lower level of substrate accumulation. In S. pombe, proton movements, as shown by internal acidification, accompanied malate uptake, consistent with the proton/dicarboxylate mechanism previously proposed. Surprisingly, no proton fluxes were observed during Mae1p-mediated L-malic acid import in S. cerevisiae, and intracellular pH remained constant. This suggests that, in S. cerevisiae, either there is a proton counterflow or the Mae1p permease functions differently from a proton/dicarboxylate symport.
Characterization of a Human Peptide Deformylase:  Implications for Antibacterial Drug Design (2003)

Ribosomal protein synthesis in eubacteria and eukaryotic organelles initiates with an N-formylmethionyl-tRNA(i), resulting in N-terminal formylation of all nascent polypeptides. Peptide deformylase (PDF) catalyzes the subsequent removal of the N-terminal formyl group from the majority of bacterial proteins. Deformylation was for a long time thought to be a feature unique to the prokaryotes, making PDF an attractive target for designing novel antibiotics. However, recent genomic sequencing has revealed PDF-like sequences in many eukaryotes, including man. In this work, the cDNA encoding Homo sapiens PDF (HsPDF) has been cloned and a truncated form that lacks the N-terminal 58-amino-acid targeting sequence was overexpressed in Escherichia coli. The recombinant, Co(2+)-substituted protein is catalytically active in deformylating N-formylated peptides, shares many of the properties of bacterial PDF, and is strongly inhibited by specific PDF inhibitors. Expression of HsPDF fused to the enhanced green fluorescence protein in human embryonic kidney cells revealed its location in the mitochondrion. However, HsPDF is much less active than its bacterial counterpart, providing a possible explanation for the apparent lack of deformylation in the mammalian mitochondria. The lower catalytic activity is at least partially due to mutation of a highly conserved residue (Leu-91 in E. coli PDF) in mammalian PDF. PDF inhibitors had no detectable effect on two different human cell lines. These results suggest that HsPDF is likely an evolutional remnant without any functional role in protein formylation/deformylation and validates PDF as an excellent target for antibacterial drug design.
The goods, the bads and the uglies: Supporting decisions in malware detection through visual analytics (2017)

Malware associated with Web downloads is responsible for many attacks trying to execute malicious code on a remote machine. Web browsers are protected by anti-malware utilities that try to distinguish between good downloads and bad downloads, blocking the bad ones and alerting the user. In order to cope with the uncertainty of such a process, very often the final decision is made using suitable thresholds, giving rise to a 3 categories classification: good downloads, bad downloads, and “in the middle” downloads (i.e., the uglies). In this situation, it is possible to involve the user (e.g., the security manager) in the decision loop, presenting him with the details of the decision process in a way he can either be more confident about the system decisions or he can refine what has been done automatically, e.g., promoting an ugly download to a good one. The paper addresses this problem presenting a visual analytics solution supporting the analysis of the classification system presented in AMICO [24], providing the user with a better understanding of the classification decisions and the possibility of changing the classification results. A prototype is available at: http://awareserver.dis.uniroma1.it:11768/malvis/.