gebhart/patrepeval huggingface dataset:
Regulation of the<i>Oct-4</i>gene by nuclear receptors (1994)

To unravel the network of transcription factors established during development it is important to understand how genes specifically expressed during embryogenesis are regulated. Oct-4 is a transcription factor whose expression is associated with an undifferentiated cell phenotype in the early mouse embryo and is downregulated when such cells differentiate. An enhancer in the upstream region of Oct-4 has previously been reported as being sufficient to mediate the cell-type specific expression and RA-dependent down-regulation in EC cells, although the enhancer contains no retinoic acid receptor (RAR) binding sites. Here we report the identification of promoter elements important for the regulation of the Oct-4 gene in EC cells. A region of the proximal Oct-4 promoter contains an overlapping set of regulatory elements including a high affinity binding site for Sp1 and three direct repeats of an AGGTCA-like sequence with either +1 or 0 spacing. Binding and transient transfection assays reveal that Oct-4 is subject to negative regulation by different members of the steroid-thyroid hormone receptor superfamily. Specifically, important roles for ARP-1 and RAR in Oct-4 expression are indicated.
Plasticity of Cortical Projections after Stroke (2003)

Ischemic stroke produces cell death and disability, and a process of repair and partial recovery. Plasticity within cortical connections after stroke leads to partial recovery of function after the initial injury. Physiologically, cortical connections after stroke become hyperexcitable and more susceptible to the induction of LTP Stroke produces changes in the distribution and laterality of sensory, motor, and language representations within the brain that correlate with functional recovery. Anatomically, ischemic lesions induce axonal sprouting within local, intracortical projections and long distance, interhemispheric projections. This postischemic axonal sprouting establishes substantially new patterns of cortical connections with de-afferented or partially damaged brain areas. Axonal sprouting after ischemic lesions is induced by a transient pattern of synchronous, low-frequency neuronal activity in a network of cortical areas connected to the infarct. This pattern of neuronal activity that induces axonal sprouting in the adult after ischemic lesions resembles that seen in the developing brain during axonal elongation and synaptogenesis. Thus, stroke induces a process of remapping and reconnection within the adult brain through changes in neuronal activity that may involve a reactivation of developmental programs in areas connected to the infarct.
Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor. (1993)

We have isolated a cDNA clone (mERD2) for the mammalian (bovine) homologue of the yeast ERD2 gene, which codes for the yeast HDEL receptor. The deduced amino acid sequence bears extensive homology to its yeast counterpart and is almost identical to a previously described human sequence. The sequence predicts a very hydrophobic protein with multiple membrane spanning domains, as confirmed by analysis of the in vitro translation product. The protein encoded by mERD2 (p23) has widespread occurrence, being present in all the cell types examined. p23 was localized to the cis-side of the Golgi apparatus and to a spotty intermediate compartment which mediates ER to Golgi transport. A majority of the intracellular staining could be accumulated in the intermediate compartment by a low temperature (15 degrees C) or brefeldin A. During recovery from these treatments, the spotty intermediate compartment staining of p23 was shifted to the perinuclear staining of the Golgi apparatus and tubular structures marked by p23 were observed. These tubular structures may serve to mediate transport between the intermediate compartment and the Golgi apparatus.
A comparison of tall fescue and orchardgrass silages for lactating cows (1993)

The feeding value of tall fescue silage (Festuca arundinacea schreb.) harvested at the boot stage of maturity with a crude protein (CP) content of 15.4% was compared to that of orchardgrass silage (Dactylis glomerata) harvested at the same stage of maturity with a CP content of 12.5%. Two feeding trials with lactating cows were used in this comparison. The first trial employed 10 cows in a 2 × 2 Latin- square, with treatment period 35 d in length. In the second experiment five cows were used in a preference trial where individual feed intakes, duration of feeding, and rate of forage consumption were monitored electronically for a period of 9 d.In the first trial, the cows consumed more tall fescue than orchardgrass silage (P < 0.05) (14.08 vs. 12.90 kg d −1 dry matter (DM)) but there were no differences between cows fed the two silages in milk yield (30.4 vs. 29.8 kg d −1 ) or milk compositon. Source of silage did not influence rumen fluid pH, molar percent of volatile fatty acids or plasma glucose; however, plasma urea-N levels were significantly higher (P < 0.05) (17.00 vs. 15.14 mg dL −1 ) when cows were fed tall fescue silage compared with when they were fed orchardgrass silage. In the preference trial employing electronically monitored forage feeding gates, all five cows demonstrated a preference for the tall fescue silage consuming a daily average of 9.83 kg DM for tall fescue compared with 3.73 kg for orchardgrass silage. Cows spent more time (P < 0.05) (68.3 vs. 14.1 min −1 ) and ate faster (69.6 vs. 54.0 g DM min −1 ) from the gates offering tall fescue silage compared with the gates offering orchardgrass silage. From the results of these two trials it was concluded that tall fescue silage was comparable to orchardgrass in supporting milk production and superior to orchardgrass in terms of palatability. Key words: Tall fescue, silage preference, lactating cows
Detection of group D salmonellae in blood culture broth and of soluble antigen by tube agglutination using an O-9 monoclonal antibody latex conjugate (1987)

Latex particles sensitized with a Salmonella O-9 monoclonal antibody were used to detect group D salmonellae in blood culture broths. The system was found to be 100% accurate when used on 104 clinical specimens that included 13 S. typhi isolates. Enteric fever could thus be diagnosed as early as 1 day after the initiation of culture in some (18%) cases. The latex particles were also used in an experimental situation to detect soluble S. typhi lipopolysaccharide by a tube agglutination method. This was found to be more than four times as sensitive as the conventional slide agglutination method because at least 50 ng of antigen per ml in either buffer or urine was detected, albeit with less efficiency when serum was used.
Macaulay on flogging vs refutation (1956)

Journal Article Macaulay on flogging vs refutation Get access Edward Rosen Edward Rosen 1City College, New York Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 3, Issue 7, 1 July 1956, Page 315, https://doi.org/10.1093/nq/3.7.315a Published: 01 July 1956
Using program information to plan evaluations (1985)

Abstract Information that describes a program's implementation and client audience can help the evaluator tailor the study to the constraints of particular settings and increase the likelihood that the evaluation can be implemented as planned.
Estimates of Population Size, Dispersal, and Longevity of Domestic Aedes aegypti aegypti (Diptera: Culicidae) by Mark–Release–Recapture in the Village of Shauri Moyo in Eastern Kenya (1995)

Estimates of the absolute size of a domestic population of Aedes aegypti aegypti (L.) were made in the Rabai area of Kenya, based on a single release, followed by either single or repeated recaptures. From single recapture within 24 h of release, the size of the female Ae. a. aegypti population in the Shauri Moyo village was estimated by the Lincoln index to be 365. Using a single release and repeated recaptures, population size was estimated by Jackson's positive method to be 337. Depletion of the unmarked females by daily removal sampling provided us with two additional, direct estimates of the size of the village population (451 by Kano's method and [464 +/- 18.9 SEM] by the Moran-Zippin method). The longevity of marked females was at least 9 d. The day-to-day movement of marked mosquitoes revealed the dispersal pattern of Ae. a. aegypti among houses clustered within different distance zones. Marked mosquitoes reached all houses of the village within 24 h of release. After 5 d, the dispersion of both marked and unmarked mosquitoes among houses was similar.
Fractionally-spaced subband and multiresolution adaptive filters (1991)

The topic of adaptive filtering is addressed for the case when the input and desired-response signals are split into several subbands, leading to a decomposition into multiple smaller adaptive filtering problems. The use of fractionally spaced adaptive filters to overcome the aliasing problem is proposed. This concept is shown to apply to the subband filtering setup. The fractional spacing idea is applied to several existing alternative approaches to the aliasing problem, leading to more economical solutions. Tree structures of subband filters are introduced to obtain multiresolution filters, and it is proposed to apply these filters to the demanding problem of acoustic echo cancellation. A three-fold gain, involving the modeling, tracking, and criterion (perception) issues, is obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chromosomal mapping of mutations affecting glycerol and glucose catabolism in Pseudomonas aeruginosa PAO (1985)

Mutations causing deficiencies in the inducible, membrane-associated sn-glycerol-3-phosphate dehydrogenase (glpD) and in inducible glucose transport (glcT) were mapped on the Pseudomonas aeruginosa PAO1 chromosome by using the generalized transducing phages F116L and G101. These mutations, in separate catabolic regulatory units, were cotransducible with a previously described cluster of carbohydrate catabolic gene loci (zwf-1 eda-9001 edd-1) that maps at ca. 50 to 53 min on the chromosome. Mutant strain PFB362 (glcT1) did not transport glucose and did not produce a functional, periplasmic, glucose-binding protein that is required for glucose transport. This mutation was cotransducible with zwf-1 (70%), nalA (29%), and phe-2 (19%) but not with glpD1 or leu-10. The glpD1 mutation in strain PRP408 was cotransducible with zwf-1 (5%), eda-9001 (4%), and edd-1 (1%) and also with ami-151 (17%) and phe-2 (33%). These results expand the number of known carbohydrate catabolism genes that are clustered in the 50- to 55-min region of the PAO1 chromosome and allow us to propose the following relative gene order: ami-151 glpD1 phe-2 nalA zwf-1 eda-9001 edd-1 glcT1 leu-10. Three independently obtained nal determinants for high-level resistance to nalidixic acid, which were employed in these studies, exhibited similar cotransduction frequencies with several flanking marker mutations.
Dopamine Receptor Subtypes That Induce Hyperactive Urinary Bladder Response in Anesthetized Rats (1990)

In anesthetized rats, SKF 38393 (10 mg/kg, i.v.) did not facilitate urinary bladder motility, but bromocriptine (BR, 5 mg/kg, i.v.) alone and the combination of BR (1 mg/kg, i.v.) and SKF 38393 (1 mg/kg, i.v.) induced a hyperactive bladder response (HBR). Both HBR induced by BR alone or BR and SKF 38393 combined was suppressed by SCH 23390, sulpiride or haloperidol. These results indicate that HBR is mediated by the activation of D-2 receptors, and the effects of D-2 agonists on bladder motility are potentiated by the simultaneous stimulation of D-1 receptors.
Determining the maximum time horizon for vehicles to safely follow a trajectory (2017)

Dealing with the unknown future behavior of other traffic participants is one of the main challenges when generating safe trajectories for autonomous vehicles. When the ego vehicle (i.e., the vehicle to be controlled) follows a given trajectory, an emergency maneuver should be kept available for all times in order to avoid collisions. However, generating an emergency maneuver for each time step is computationally expensive and often not required. In this paper, we propose an algorithm for determining the maximum time horizon under which the ego vehicle can safely follow a given trajectory. First, an upper and a lower bound of this time horizon are computed. Then, binary search is used to find the maximum time horizon for which safety is still guaranteed. Our algorithm reduces the frequency of generating emergency maneuvers while still guaranteeing collision-free trajectories. The approach is tested on real traffic data, and it is shown that our algorithm indeed reduces the frequency of generating emergency maneuvers compared to previous work.
Winding and air gap configurations for power inductors to reduce near magnetic field emission (2017)

This paper first developed magnetic reluctance models for magnetic inductors. The near magnetic field emission of the inductors with different winding and air gap configurations are analyzed based on the developed models. Several inductor structures are proposed to reduce the near magnetic field emission. Simulation and experiments are conducted to validate the developed techniques.
FINITE DIFFERENCE AND WAVE NUMBER MIGRATION * (1978)

A bstract Finite difference migration has been developed and popularized by J. F. Claerbout of Stanford University and is now widely used in seismic processing. For most sections finite difference migration gives results comparable to those obtained by conventional Kirchhoff migration and, where events are not dipping too much, a cleaner appearance is often apparent. However, there are two practical limitations to the method, and these occur in regions of very steep dip and where there is a large variation of the velocity in the lateral direction. It is possible to develop successively more accurate equations to deal with the steep dip problem, but above third order these schemes become prohibitively expensive to implement. The finite difference method itself introduces errors and so imposes further limitations on the angle of dip. For the effective treatment of steeply dipping beds there appears to be no method available in the time domain which does not suffer from dispersion inaccuracies. However, by developing wavenumber migration, an exact one‐way wave equation can be used, and this eliminates any error except that caused by finite sampling. The other difficulty with wave migration is the correct migration in regions with lateral velocity variation. A number of approaches are possible of which three are discussed here. The first uses an exact theory, the second is based on the deviation from a depth stratified model, and the third uses a transformation to a depth co‐ordinate system. All methods are discussed with their advantages and limitations. Finally, some examples are shown of wave migration applied to synthetic and real data.
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation (2005)

The majority of patients with systemic mast cell disease express the imatinib-resistant Asp816Val (D816V) mutation in the KIT receptor tyrosine kinase. Limited treatment options exist for aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL). We evaluated whether PKC412, a small-molecule inhibitor of KIT with a different chemical structure from imatinib, may have therapeutic use in advanced SM with the D816V KIT mutation. We treated a patient with MCL (with an associated myelodysplastic syndrome (MDS)/myeloproliferative disorder [MPD]) based on in vitro studies demonstrating that PKC412 could inhibit D816V KIT-transformed Ba/F3 cell growth with a 50% inhibitory concentration (IC50) of 30 nM to 40 nM. The patient exhibited a partial response with significant resolution of liver function abnormalities. In addition, PKC412 treatment resulted in a significant decline in the percentage of peripheral blood mast cells and serum histamine level and was associated with a decrease in KIT phosphorylation and D816V KIT mutation frequency. The patient died after 3 months of therapy due to progression of her MDS/MPD to acute myeloid leukemia (AML). This case indicates that KIT tyrosine kinase inhibition is a feasible approach in SM, but single-agent clinical efficacy may be limited by clonal evolution in the advanced leukemic phase of this disease.
Optical layer multicast: rationale, building blocks, and challenges (2003)

Optical layer multicast refers to the support of point-to-multipoint connections directly at the physical layer by employing passive devices capable of splitting the power of an input signal among several outputs. Optical multicast technology enables a broad set of applications and opens new directions to network design. We examine the underlying principles and essential components for a practical optical multicast service. We also present a set of key research challenges along with a survey of the literature.
Recent Results on Relaying for LTE-Advanced (2009)

Relays are being proposed as key technology elements for LTE-Advanced (LTE-A). This paper shows that throughput gains of using relays in a cellular network (relative to a network without relays) are highly dependent on relay coverage which is defined as the percentage of users served by relays. System-level simulations and analysis is used to illustrate the impact of relay coverage on throughput performance. Techniques to further improve the performance gains are proposed.
Universities of the united states (1896)

Journal Article Universities of the united states Get access C. F. S. Warren C. F. S. Warren 1Longford, Coventry Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s8-X, Issue 236, 4 July 1896, Page 18, https://doi.org/10.1093/nq/s8-X.236.18e Published: 04 July 1896
Relationship between the Physical Properties and Surface Area of Cellulose Derived from Adsorbates of Various Molecular Sizes. (1998)

An aqueous suspension of bacterial cellulose (BC) has such physical properties as higher viscosity, emulsion-stabilizing effect and filler retention than cellulose of other origins. The specific surface areas of BC, microfibrillated cellulose and wood pulp were evaluated by determining the maximum amounts of adsorption of Congo red, cellobiose dehydrogenase (CDH) and xyloglucan. There was a positive linear correlation between the above-mentioned physical properties of each cellulose sample and the specific surface area derived from the maximum amount of CDH adsorbed. The highest physical property values for BC result from the largest external surface area of the fibrils of BC to which CDH was adsorbed.
A Novel Buck–Boost Converter Combining KY and Buck Converters (2012)

In this letter, a buck-boost converter, i.e., 2D converter with a positive output voltage, is presented, which combines the KY converter and the traditional synchronously rectified (SR) buck converter. By doing so, the problem in voltage bucking of the KY converter can be solved, thereby increasing the application capability of the KY converter. Since such a converter operates in continuous conduction mode inherently, it possesses the nonpulsating output current, thereby not only decreasing the current stress on the output capacitor but also reducing the output voltage ripple. Above all, both the KY converter and the SR buck converter, combined into a buck-boost converter with no right-half plane zero, use the same power switches, thereby causing the required circuit to be compact and the corresponding cost to be down. Furthermore, during the magnetization period, the input voltage of the KY converter comes from the input voltage source, whereas during the demagnetization period, the input voltage of the KY converter comes from the output voltage of the SR buck converter.
Characterization of two distinct DP‐related genes from <i>Arabidopsis thaliana</i><sup>1</sup> (2000)

E2F/DP complexes play a pivotal role in the regulation of the G1/S transition in animals. Recently, plant E2F homologs have been cloned, but DP-related sequences have not been identified so far. Here we report that Arabidopsis thaliana contains at least two different DP-related genes, AtDPa and AtDPb. They exhibit an overall domain organization similar to that of their animal counterparts, although phylogenetic analysis demonstrated that they form a separate subgroup. AtDPs efficiently heterodimerize in vitro with the Arabidopsis E2F-related proteins, AtE2Fa and AtE2Fb through their dimerization domains. AtDPa and AtE2Fa are predominantly produced in actively dividing cells with highest transcript levels in early S phase cells.
HTTP Developer's Handbook (2003)

From the Publisher:
The largest group with an unsatisfied demand for a good book on HTTP is the worldwide group of Web developers. A good book on HTTP can help new and old Web developers alike, as a thorough understanding of underlying protocols can remove the dependencies on specific tool sets and help people create and maintain better Web applications as well as adapt to technologies.

HTTP has become an essential topic because the Web's importance has created an army of people creatively leveraging the Web for their specific needs. By making standards information more available to the common developer, standards compliance becomes more widespread and common, something that the industry needs.

Developers will buy HTTP Developer's Handbook because they want to advance their expertise, and because there is very little documentation available. This book will easily become the standard reference for the Internet's most dominant protocol.
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression. (1996)

Developmentally regulated genes in Drosophila, which are conserved through evolution, are potential candidates for key functions in biological processes such as cell cycle, programmed cell death, and cancer. We report cloning and characterization of the human homologue of the Drosophila seven in absentia gene (HUMSIAH), which codes for a 282 amino acids putative zinc finger protein. HUMSIAH is localized on human chromosome 16q12-q13. This gene is activated during the physiological program of cell death in the intestinal epithelium. Moreover, human cancer-derived cells selected for suppression of their tumorigenic phenotype exhibit constitutively elevated levels of HUMSIAH mRNA. A similar pattern of expression is also displayed by the p21waf1. These results suggest that mammalian seven in absentia gene, which is a target for activation by p53, may play a role in apoptosis and tumor suppression.
Monolithic vertical combdrive actuators for adaptive optics (2003)

High aspect ratio vertical combdrive actuators are demonstrated which advance the capabilities and applications of SOI-MEMS by adding additional independent degrees of freedom of operation: both upward and downward vertical pistoning motion as well as bi-directional pure rotation. The methodology for the first time enables monolithic fabrication of isolated vertical combdrive sets in the SOI device layer, with combfinger self-alignment and pre-engagement (initial overlap). This is demonstrated in a micromirror device, which exhibits four modes of actuation: bi-directional static optical deflection from -20/spl deg/ to +19/spl deg/, and independent bi-directional pistoning motion from -7.5 /spl mu/m to +8.25 /spl mu/m. Lowest resonant frequency of the device is 1491 Hz in tilting mode and 2619 Hz in pistoning mode.