gebhart/patrepeval huggingface dataset:
Crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (1993)

Chiral HPLC resolution of the phosphodiesterase IV (PDE IV) inhibitor rolipram (1) provided (-)-1, and this enantiomer was converted into its 1-(4-bromobenzyl) derivative, (+)-2. X-ray structural analysis of (+)-2 established the absolute configuration as R, which provides the first direct evidence for a previously assumed assignment of configuration. The crystal structure of (+)-2 and the PDE inhibitory activity of both enantiomers of 2 are discussed in the context of a previously proposed topological model.
Apnea Monitoring by Acoustic Detection of Airflow (1983)

An acoustic monitor to detect apnea in infants has been developed. Recordings of a signal derived from breath sounds at the nose were made in eight premature infants and compared with observation of the infant and with transthoracic impedance and ECG monitoring. The acoustic monitor detected 26 episodes of apnea lasting 15 seconds or longer which were confirmed by observation and by heart rate slowing of at least 20 beats per minute. Only seven of these episodes were detected by the impedance monitor. The ECG monitor alarmed during the nine spells in which heart rate dropped below 100 beats per minute, 27.5 +/- 9.7 seconds after breath sounds ceased. Inasmuch as the acoustic device detects absent airflow during central or obstructive apnea before bradycardia occurs and is insensitive to body movements, it represents an improved monitoring technique for infants with apnea.
A Facile Preparation of 3-Substituted 2-Thioxo-tetrahydoquinazolin-4-ones by the Reaction of Anthranilamide with Isothiocynates (1987)

Substituted 2-thioxa-tetrahydraqu~naz~lin-&-ones (4a-d) can be synthesized I n a convenient procedure directly by a treatment of anthranilemide with isothiocyanates st room temperature.However, anthranAmlde was reacted with 4-isothiocyanato-I-benrylplperldme ( Z e ) leading to the formation of 2-[3-(1-benzyl-4-piperidiny1)lthioureido-
Global Research Trends on Geospatial Information by Keyword Network Analysis (2015)

본 연구는 1998년부터 2013년까지 지리공간정보와 관련된 연구 논문에 대해 키워드 네트워크 분석 기법을 적용하여 분석하고 글로벌 차원에서 지리공간정보 연구의 흐름을 도출하는데 목적이 있다. 이를 위해 Web of Science 학술 자료 검색 엔진을 이용하여 지리공간정보와 관련된 논문과 주요 키워드를 추출하였다. 그리고 추출된 키워드를 이용해 키워드 네트워크 자료를 구축하고 시기별 키워드의 연결중심성과 매개중심성, 근접중심성을 분석하였다. 그 결과 다양한 분야에서 지리공간정보가 활용되어 왔음을 확인할 수 있었고 관련된 기술의 연구 동향을 계량적으로 파악할 수 있었다. 이러한 연구 결과는 지리공간정보에 대한 정책과 연구 개발 계획을 과학적으로 수립하는데 활용될 수 있을 것으로 판단된다. The aim of this study is to examine the research trends of global scientific production of Geospatial Information (GI) papers from 1998 to 2013 by using keyword network analysis. This study constructed keyword network model through papers and keywords related to GI research retrieved from the Web of Science DB and performed keyword network analysis such as Degree Centrality, Betweenness Centrality, and Closeness Centrality. The results show that GI has been steadily applied to various fields, and also the research trends of GI techniques could be quantitatively characterized through keyword network analysis. This study result can be applied to establish the policies and the national R&D planning of geospatial information.
Prevalence of solar damage and actinic keratosis in a Merseyside population (2000)

This study examines the prevalence of sun-related damage to the skin in a caucasian population in north-west England. The importance of constitutional factors (complexion, skin type and age) as well as environmental and occupational exposures for the development of actinic keratosis (AK) and skin cancers was assessed in people over 40 years of age attending outpatient clinics (non-dermatology) at four centres in north-west England (Mersey region). Nine hundred and sixty-eight volunteers (531 men and 437 women) were recruited. The overall prevalence of AK was 15.4% in men and 5.9% in women. The prevalence was strongly related to age in both sexes, being 34.1% and 18.2%, respectively, in men and women aged 70 years and above, and was most strongly related to two objective signs of sun exposure, namely degree of solar elastosis and presence of solar lentigines. The prevalence of AK was higher in subjects with red hair and freckles, particularly women. There was no evidence of an increased prevalence of AK in relation to any occupation. There was a high prevalence of seborrhoeic keratosis and viral warts in both sexes, which was age-related in the case of seborrhoeic keratosis. Ten cases of basal cell carcinoma, eight cases of Bowen's disease and one case of malignant melanoma were identified. This study shows that the sun exposure received in 'normal' life in England is sufficient to cause potentially malignant skin damage in a significant proportion of the population.
Electrophoretic Studies of Turbidity Removal by Coagulation With Aluminum Sulfate (1961)

One important factor affecting coagulation is the negative zeta potential, often referred to as the charge, that is associated with natural clay particles suspended in water. This article discusses a study of the zeta potential of clay particles that were found to be dependent on the pH and on the alum dosage. An amount of alum equivalent to several times the base‐exchange capacity of the clay suspension was required to neutralize the particle charge. Clarification was best in the range pH 7.5 – 8.5 where the particles were negative, rather than at pH values where the particle charge had been neutralized. Fair coagulation was often obtained below pH 4.5 where the particles were nearly neutral. In many instances, residual turbidities changed sharply without any accompanying change in mobility values. The eight coagulant aids used with alum all could be made to improve or inhibit coagulation by selection of dosages of alum and aid. As in the coagulation at different pH values, final particle charges could not be correlated with residual turbidities.
Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Subjects >70 Years of Age (2001)

Aortic pulse wave velocity (PWV) is a significant and independent predictor of cardiovascular mortality in subjects with essential hypertension and in patients with end-stage renal disease. Its contribution to cardiovascular risk in subjects 70 to 100 years old has never been tested. A cohort of 141 subjects (mean+/-SD age, 87.1+/-6.6 years) was studied in 3 geriatrics departments in a Paris suburb. Together with sphygmomanometric blood pressure measurements, aortic PWV was measured with a validated automatic device. During the 30-month follow-up, 56 patients died (27 from cardiovascular events). Logistic regressions indicated that age (P=0.005) and a loss of autonomy (P=0.01) were the best predictors of overall mortality. For cardiovascular mortality, aortic PWV was the major risk predictor (P=0.016). The odds ratio was 1.19 (95% confidence interval, 1.03 to 1.37). Antihypertensive drug treatment and blood pressure, including systolic and pulse pressure, had no additive role. In subjects 70 to 100 years old, aortic PWV is a strong, independent predictor of cardiovascular death, whereas systolic or pulse pressure was not. This prospective result will need to be confirmed in an intervention trial.
Chemical Vapor Deposition of Electronic Materials (1973)

This article reviews published data on the mechanical properties of additively manufactured metallic materials. The additive manufacturing techniques utilized to generate samples covered in this review include powder bed fusion (e.g., EBM, SLM, DMLS) and ...Read More
Effect of radiotherapy and chemotherapy on bone marrow activity (2010)

18F-FLT uptake in the bone marrow decreases after RT, but not after chemotherapy. We conclude that 18F-FLT-PET is a potential noninvasive tool that can be used in the assessment of quantification of cellular division in the hematopoietic organ.
Signaling System in <i>Porphyromonas gingivalis</i> Based on a LuxS Protein (2001)

The luxS gene of quorum-sensing Vibrio harveyi is required for type 2 autoinducer production. We identified a Porphyromonas gingivalis open reading frame encoding a predicted peptide of 161 aa that shares 29% identity with the amino acid sequence of the LuxS protein of V. harveyi. Conditioned medium from a late-log-phase P. gingivalis culture induced the luciferase operon of V. harveyi, but that from a luxS insertional mutant did not. In P. gingivalis, the expression of luxS mRNA was environmentally controlled and varied according to the cell density and the osmolarity of the culture medium. In addition, differential display PCR showed that the inactivation of P. gingivalis luxS resulted in up-regulation of a hemin acquisition protein and an arginine-specific protease and reduced expression of a hemin-regulated protein, a TonB homologue, and an excinuclease. The data suggest that the luxS gene in P. gingivalis may function to control the expression of genes involved in the acquisition of hemin.
The trisubstituted-triazole approach to extended functional naphthalocyanines (2011)

Recently, a novel modular approach to octatriazole-derived phthalocyanines (Pcs; 1) was developed and optimized in our group; herein, the pool of the functional Pc materials was expanded for an additional candidate (2), a fused derivative of 1. Compared with 1, the aromaticity in 2 is extended by an additional four benzene and eight triazole rings and, in addition, the triazole units and the Pc core co-create four functional, in-plane cavities. Various methods to link the unsubstituted carbon atoms of the neighboring triazoles in 1 to afford atomically flat naphthalocyanine (Nc) analogs (2), containing eight fused triazole moieties, were studied. Several synthetic routes were designed, among them the trisubstituted-triazole approach, which was found to be the most suitable route. The crucial steps of this approach, the copper-catalyzed azide-haloalkyne cycloaddition and the intramolecular homocoupling reactions, were first studied on a model system; subsequently, this methodology was applied in the synthesis of the desired Nc 2. The increased core size and the π-electron deficient structure predict this class of Ncs to possess very strong aggregation properties. Moreover, owing to the presence of four tridentate half-cavities, the final properties of the molecule or the assembly can, in principle, be further tuned by doping with metals or guest molecules.
Low-Light Image Enhancement with Attention and Multi-level Feature Fusion (2019)

Low-light image enhancement has made impressive progress with convolutional neural networks (CNNs). However, most existing CNNs-based networks ignore the importance of feature channels and multi-level features. To address these issues, we propose a novel low-light image enhancement network. First, we establish Feature Extraction Block (FEB) to extract features and Feature Fusion Block (FFB) to fuse multi-level features. Then, we adopt a compact channel attention module to re-define the channel importance of input features at the beginning of each Feature Extraction Block (FEB) and Feature Fusion Block (FFB). Besides, we adopt two types of low-light image datasets for training, concluding synthetic images and real-world images. Experiments show that our new network makes competitive progress for low-light image enhancement compared with the state-of-the-art methods.
Automatic processing in moiré deflectometry by local fringe direction calculation (1998)

An algorithm for accurately extracting the local fringe direction is presented. The algorithm estimates, in the neighborhood of n x n points, the direction of the gradient that points normal to the local fringe direction. The performance of four different derivative kernels is also compared. Since this method is sensitive to noise and variations in background and amplitude, a preprocessing step is used to limit these error sources. The method has been applied to the moiré deflectogram of a spherical and a progressive addition ophthalmic lens, resulting in a map of the refractive power of these lenses. The results are compared with the data obtained with a commercial focimeter. This technique is useful for analyzing the fringe patterns where the fringe direction is variable and must be obtained locally.
Visual tools for information retrieval (2002)

This paper introduces a novel representation that can be used as a visualization tool as well as a visual query language to help users search for information. High-level visual retrieval tools are described that enable users to explore, manage, and relate large information spaces to their interests. The following tools are developed: (1) The query outliner enables users to structure and edit complex queries. (2) The query spreadsheet is a novel representation that visualizes all the possible relationships among N variables, and it allows users to specify Boolean queries graphically. Arbitrarily complex queries can be created by using the query spreadsheets as building blocks and organizing them in a hierarchical structure. (3) The query overview displays the complete structure of a complex query and it can be used as a navigation tool. The presented visual framework has applications in such areas as information retrieval, electronic mail filtering, human resource management or financial portfolio management.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of a met-enkephalin analogue on growth hormone, prolactin, gonadotropins, cortisol and thyroid stimulating hormone in healthy elderly men (1992)

The aim of the study was to evaluate the effect of the guanyl derivative of the opioid analogue D-ala2,MePhe4-Met-enkephalin-(o)-ol (G-DAMME) on pituitary secretion in healthy elderly men. Nine healthy elderly men (65-88 years) and 10 young adults (20-30 years) were studied. GH, PRL, gonadotropins, cortisol (to evaluate the effect on ACTH) and TSH were measured after G-DAMME (0.25 mg iv) or placebo administration. In elderly men, the GH response to G-DAMME was reduced or absent, while prompt GH release was found in all young men. G-DAMME lowered LH levels in young men but not in elderly men. No significant variations in FSH levels after G-DAMME and placebo were noted in either group of subjects. A similar and significant rise in PRL and TSH, and a fall in cortisol, after G-DAMME was observed in both elderly and young adults. We have demonstrated that the sensitivity to opioid modulation by G-DAMME on PRL, TSH and cortisol secretion is unchanged with aging. On the other hand, the data indicate that LH and GH responsiveness to G-DAMME change with age.
SWARTZ,OLOF IN BOSTON, 1783 (1982)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
TiO<sub>2</sub> Films Loaded with Silver Nanoparticles:  Control of Multicolor Photochromic Behavior (2004)

Ag-TiO(2) films exhibiting multicolor photochromism were prepared by photoelectrochemical reduction of Ag(+) to Ag nanoparticles in nanoporous TiO(2) films under UV light. Color of the Ag-TiO(2) film, initially brownish-gray, changes under a colored visible light to the color of the light and reverts to brownish-gray under UV light. Their chromogenic properties were improved by simultaneous irradiation for Ag deposition with UV and blue lights to suppress the formation of anisotropic Ag particles. Nonvolatilization of a color image was also achieved by removing Ag(+) that was generated during the irradiation with a colored light. Once nonvolatilized, the image can be reproduced by UV light, even after the image is discolored under white light. This new effect evidenced that nanopores in the TiO(2) film determine the resonance wavelengths of the Ag particles, as their molds. In addition, solvatochromic behavior of the Ag-TiO(2) film proved that nanospaces left around the Ag nanoparticles affect the resonance wavelengths of the Ag particles.
BEHAVIOUR OF GOLD METAL AS AN IMPURITY FOR THE CHEMICAL VAPOUR DEPOSITION OF TITANIUM NITRIDE WHISKERS ON QUARTZ GLASS (1975)

Abstract The role of gold metal for whisker growth of TiN according to reaction TiCl4 + 1⁄2N2 + 2H2 \ightharpoonupTiN + 4HCl was investigated, and it was concluded that the gold metal reacted at growth conditions with quartz glass to give an Au–Ti–Si alloy which was an important liquid phase in VLS growth of TiN crystals.
Three possible disulfides in the acetylcholine receptor alpha-subunit. (1988)

The cysteinyl residues of the acetylcholine receptor alpha-subunit of Torpedo californica were analyzed. All seven cysteines could be accounted for. Three possible disulfide bridges and one unpaired cysteine were indicated. The disulfide linkages were as follows: Cys128 to Cys142; Cys192 to Cys193; Cys412 to Cys418 (Cys222 is unpaired). The identification of cysteinyl residues was accomplished by a modified protein blot procedure. Cysteinyl residues of intact nicotinic acetylcholine receptor were selectively biotinylated with 3-(N-maleimidopropionyl)biocytin and subsequently detected by the 125I-labeled avidin overlay of blotted Staphylococcus aureus V8 proteolyzed alpha-subunits. Two pairs of cysteines (Cys128/Cys142 and Cys412/Cys418) could be demonstrated only after Na(BH4) reduction of the acetylcholine receptor. Cysteine residues 192 and 193 are particularly sensitive to reduction; 0.1 mM dithiothreitol is sufficient.
Design and Analysis of Piezoelectric Transformer Converters (1997)

Piezoelectric ceramics are characterized as smart materials and have been widely used in the area of actuators and sensors. The principle operation of a piezoelectric transformer (PT) is a combined function of actuators and sensors so that energy can be transformed from electrical form to electrical form via mechanical vibration. Since PTs behave as band-pass filters, it is particularly important to control their gains as transformers and to operate them efficiently as power-transferring components. In order to incorporate a PT into amplifier design and to match it to the linear or nonlinear loads, suitable electrical equivalent circuits are required for the frequency range of interest. The study of the accuracy of PT models is carried out and verified from several points of view, including input impedance, voltage gain, and efficiency. From the characteristics of the PTs, it follows that the efficiency of the PTs is a strong function of load and frequency. Because of the big intrinsic capacitors, adding inductive loads to the PTs is essential to obtain a satisfactory efficiency for the PTs and amplifiers. Power-flow method is studied and modified to obtain the maximum efficiency of the converter. The algorithm for designing a PT converter or inverter is to calculate the optimal load termination, YOPT, of the PT first so that the efficiency (power gain) of the PT is maximized. And then the efficiency of the dc/ac inverter is optimized according to the input impedance, ZIN, of the PT with an optimal load termination. Because the PTs are low-power devices, the general requirements for the applications of the PTs include low-power, low cost, and high efficiency. It is important to reduce the number of inductive components and switches in amplifier or dc/ac inverter designs for PT applications. High-voltage piezoelectric transformers have been adopted by power electronic engineers and researchers worldwide. A complete inverter with HVPT for CCFL or neon lamps was built, and the experimental results are presented. However, design issues such as packaging, thermal effects, amplifier circuits, control methods, and matching between amplifiers and loads need to be explored further.
Regulation and Function of Lactate Oxidation in <i>Streptococcus faecium</i> (1968)

Regulation of the synthesis and function of an l(+)-specific lactate-oxidizing enzyme system found in a homofermentative Streptococcus was investigated. With the exception of fructose, aerobic growth at the expense of a variety of substrates resulted in the formation of a lactate oxidation system; anaerobic growth resulted in a marked reduction or complete loss of lactate-oxidizing activity. Growth on fructose, under aerobic and anaerobic conditions, invariably produced a decrease in the activity of the lactate oxidation system. A negative control, activated by an early intermediate product of glycolysis, appeared to be responsible for repression of the lactate-oxidizing enzyme(s). The enzyme system confers upon the organism the ability to grow aerobically at the expense of l(+)-lactic acid.
The GRClass visual programming system (2002)

The GRClass system, which combines graphics, relations, and classes to provide a visual interface for programming graph data structures within an object-oriented framework, is discussed. This is done by extending the object-oriented model with interobject relations. These relations are then used to directly implement the conceptual model of the graph data structures. Within the GRClass framework, data structures are objects that maintain relation tables. These relations and the objects participating in the relations constitute the form of the data structure. A graphical notation is used to specify the possible relations and to manipulate the relation graph. GRClass is implemented within the Andrew Toolkit programming environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Study of MAC Address Randomization in Mobile Devices and When it Fails (2017)

Media Access Control (MAC) address randomization is a privacy technique whereby mobile devices rotate through random hardware addresses in order to prevent observers from singling out their traffic or physical location from other nearby devices. Adoption of this technology, however, has been sporadic and varied across device manufacturers. In this paper, we present the first wide-scale study of MAC address randomization in the wild, including a detailed breakdown of different randomization techniques by operating system, manufacturer, and model of device.
Compendium of single event failures in power MOSFETs (2002)

This compendium of SEGR and SEB data organizes results from several laboratories comparing failure thresholds for several different manufacturers and technologies. The results of this compendium are aimed at the designer to show the possible variations between manufacturers and processes. The compendium incorporates previously published data with the most recent data obtained from various sources.
The Reaction of Methylamine with Periodate-Oxidized Adenosine 5'-Phosphate (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Methylamine with Periodate-Oxidized Adenosine 5'-PhosphateJoseph X. KhymCite this: Biochemistry 1963, 2, 2, 344–350Publication Date (Print):March 1, 1963Publication History Published online1 May 2002Published inissue 1 March 1963https://pubs.acs.org/doi/10.1021/bi00902a029https://doi.org/10.1021/bi00902a029research-articleACS PublicationsRequest reuse permissionsArticle Views277Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts