gebhart/patrepeval huggingface dataset:
Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host (2013)

The overexpression of activated, myristoylated Akt in the midgut of female transgenic Anopheles stephensi results in resistance to infection with the human malaria parasite Plasmodium falciparum but also decreased lifespan. In the present study, the understanding of mitochondria-dependent midgut homeostasis has been expanded to explain this apparent paradox in an insect of major medical importance. Given that Akt signaling is essential for cell growth and survival, we hypothesized that sustained Akt activation in the mosquito midgut would alter the balance of critical pathways that control mitochondrial dynamics to enhance parasite killing at some cost to survivorship. Toxic reactive oxygen and nitrogen species (RNOS) rise to high levels in the midgut after blood feeding, due to a combination of high NO production and a decline in FOXO-dependent antioxidants. Despite an apparent increase in mitochondrial biogenesis in young females (3 d), energy deficiencies were apparent as decreased oxidative phosphorylation and increased [AMP]/[ATP] ratios. In addition, mitochondrial mass was lower and accompanied by the presence of stalled autophagosomes in the posterior midgut, a critical site for blood digestion and stem cell-mediated epithelial maintenance and repair, and by functional degradation of the epithelial barrier. By 18 d, the age at which An. stephensi would transmit P. falciparum to human hosts, mitochondrial dysfunction coupled to Akt-mediated repression of autophagy/mitophagy was more evident and midgut epithelial structure was markedly compromised. Inhibition of RNOS by co-feeding of the nitric-oxide synthase inhibitor L-NAME at infection abrogated Akt-dependent killing of P. falciparum that begins within 18 h of infection in 3-5 d old mosquitoes. Hence, Akt-induced changes in mitochondrial dynamics perturb midgut homeostasis to enhance parasite resistance and decrease mosquito infective lifespan. Further, quality control of mitochondrial function in the midgut is necessary for the maintenance of midgut health as reflected in energy homeostasis and tissue repair and renewal.
Signal interception: performance advantages of cyclic-feature detectors (1992)

The problem of detecting the presence of spread-spectrum phase-shift-keyed signals in variable noise and interference backgrounds is considered, and the performances of four detectors are evaluated and compared. The detectors include the optimum radiometer, the optimum modified radiometer that jointly estimates the noise level and detects the signal, and the maximum-SNR spectral-line regenerator for spectral-line frequencies equal to the chip rate and the doubled carrier frequency. It is concluded that the spectral-line regenerators can outperform both types of radiometers by a wide margin. The performance advantages are quantified in terms of receiver operating characteristics for several noise and interference environments and receiver collection times.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Chemistry Research and Development Semiannual Progress Report January through June 1974 (1974)

Progress is reported in a number of projects related to process chemistry, chemical technology, chemistry instrumentation, and pilot plant development, as well as miscellaneous staff projects.
Arsenic Trioxide Selectively Induces Early and Extensive Apoptosis via the APO2/Caspase-8 Pathway Engaging the Mitochondrial Pathway in Myeloma Cells with Mutant p53 (2003)

Arsenic trioxide (ATO) is effective in the treatment of acute promyelocytic leukemia (APL) and induces apoptosis in APL cells and in a great variety of other cancer cells. We have previously shown that ATO induces apoptosis in myeloma cells in two different modes depending on p53 status in the cells. In cells expressing mutated p53, ATO induced, G2/M arrest and activation caspase 8 and 3 and rapid and extensive apoptosis. Myeloma cells expressing w.t. p53, ATO induced G1 arrest and delayed apoptosis with activation of caspase 9 and 3. APO2/TRAIL receptor expression was induced in both cell types and APO2/TRAIL synergized with ATO in the induction of apoptosis. Here we tested the effect of ATO on mitochondrial membrane potential (MMP) in myeloma cells expressing mutated or w.t. p53. In myeloma cells expressing mutated p53, depolarization of MMP occurred early, concomitant with induction of APO2/TRAIL, activation of BID and release of AIF, preceding apoptosis. However, in cells expressing w.t. p53, APO2/TRAIL is not induced, BID is not cleaved and depolarization of MMP occurs concurrently with cytochrome c release and apoptosis. These results explain the greater sensitivity to ATO of cells with mutated p53 and suggest perhaps a general mechanism for ATO-induced apoptosis.
Film bulk acoustic resonator pressure sensor with self temperature reference (2012)

A novel film bulk acoustic resonator (FBAR) with two resonant frequencies which have opposite reactions to temperature changes has been designed. The two resonant modes respond differently to changes in temperature and pressure, with the frequency shift being linearly correlated with temperature and pressure changes. By utilizing the FBAR's sealed back trench as a cavity, an on-chip single FBAR sensor suitable for measuring pressure and temperature simultaneously is proposed and demonstrated. The experimental results show that the pressure coefficient of frequency for the lower frequency peak of the FBAR sensors is approximately −17.4 ppm kPa−1, while that for the second peak is approximately −6.1 ppm kPa−1, both of them being much more sensitive than other existing pressure sensors. This dual mode on-chip pressure sensor is simple in structure and operation, can be fabricated at very low cost, and yet requires no specific package, therefore has great potential for applications.
P<sub>2y</sub> purinoceptor responses of β cells and vascular bed are preserved in diabetic rat pancreas (1992)

1. To investigate the effect of experimental diabetes on the P2y purinoceptor responses of pancreatic beta-cells and vascular bed, we used adenosine-5'-O-(2-thiodiphosphate) (ADP beta S), a potent and stable P2y agonist. This work was performed in the isolated perfused pancreas of the rat. 2. Diabetes was induced by streptozotocin (66 mg kg-1, i.p.). Five weeks after the induction of diabetes, on the day of pancreas isolation, the animals displayed marked hyperglycaemia (37.6 +/- 2.7 mM). Age-matched rats were used as controls. 3. Insulin response to a glucose stimulation from 5 to 10 mM was completely lost and stimulation of insulin release by the sulphonylurea, tolbutamide (185 microM), was drastically impaired in the diabetic pancreas (maximum responses were 1.5 +/- 0.4 and 7.0 +/- 1.4 ng min-1 for diabetic and age-matched rats respectively). 4. In contrast, in the diabetic pancreas ADP beta S (15 microM), infused in the presence of glucose 5 mM, elicited an immediate and significant insulin release similar to that observed in the age-matched pancreas (maximum responses were 7.6 +/- 1.5 and 6.7 +/- 1.3 ng min-1 respectively). This ADP beta S stimulating effect occurred independently of the glucose concentration (5, 8.3 and 28 mM) in the diabetic pancreas. On pancreatic vascular resistance, ADP beta S induced a similar vasodilatation in diabetic and age-matched rats. 5. In conclusion, ADP beta S retains its insulin stimulatory and vasodilator effects in experimental diabetes; P2y purinoceptors could therefore be considered as a new target for the development of antidiabetic drugs.
Stochastic Generator of Chemical Structure. 3. Reaction Network Generation (2000)

A new method to generate chemical reaction network is proposed. The particularity of the method is that network generation and mechanism reduction are performed simultaneously using sampling techniques. Our method is tested for hydrocarbon thermal cracking. Results and theoretical arguments demonstrate that our method scales in polynomial time while other deterministic network generator scale in exponential time. This finding offers the possibility to investigate complex reacting systems such as those studied in petroleum refining and combustion.
New Techniques for Labor Analgesia: PCEA and CSE (2003)

Wake Forest University School of Medicine, Winston-Salem, North Carolina Correspondence:Robert D'Angelo, MD, Obstetric Anesthesia Forsyth Medical Center 3333 Silas Creek Pkwy Winston-Salem, NC 27103 E-mail: [email protected]
Nucleotide sequence of<i>Marchantia polymorpha</i>chloroplast DNA: a region possibly encoding three tRNAs and three proteins including a homologue of<i>E. coli</i>ribosomal protein S14 (1984)

The nucleotide sequence of a region of Marchantia polymorpha chloroplast DNA was determined. On this DNA sequence (3.38kb), three open reading frames (ORFs) and three putative tRNA genes were detected in the following order: -ORF701-tRNASer(UGA)-ORF702-tRNAGly(GCC)-initiator tRNAMet(CAU)-ORF703-. The ORF703 is composed of 100 codons in which those for lysine (15%) and arginine (11%) are abundant, and could be accounted for as a counterpart of E. coli ribosomal protein S14 since they share 45% homology in the amino acid sequences. The ORF701 appears to code for a membrane protein, showing a periodic appearance of seven clusters of hydrophobic amino acids. Although the mechanisms remain unknown, the ORF701 causes a streptomycin-sensitive phenotype in resistant mutants of E. coli. The ORFs and tRNA genes are separated from each other by extremely AT-rich spacers containing sequences of dyad symmetry. The third letter positions of the codons in the ORFs are also rich in A and T residues.
[A near-infrared diffuse reflectance analysis method for the noninvasive quantitative analysis of ambroxol hydrochloride tablets]. (2004)

Results showed that the NIRDRA method was rapid, simple, noninvasive and sensitive, and it can be applied to assay the content of ambroxol hydrochloride in half-finished product particles non-blister-packed and blistered tablets.
A fully automatable enzymatic method for DNA extraction from plant tissues (2005)

In combination with conventional DNA isolation techniques, the new enzymatic method allows to obtain high-yield, high-molecular weight DNA, which can be used for many applications, including genome characterization by AFLP, RAPD and SSR. Automation of the protocol (from leaf disks to DNA) is possible with existing workstations.
UV-induced index changes in Undoped Fluoride glass (2005)

Undoped fluoride glass slides have been exposed to pulsed 193-nm ultraviolet (UV) irradiation. Their absorption changes have been measured to evaluate UV-induced index changes using Kramers-Kronig relation. A layer-peeling polishing technique was applied to characterize the local UV-induced index change of highly absorbing glass. Index changes up to 1.75/spl times/10/sup -4/ have been evaluated with this method in fluorozirco-aluminate glass. Fluoroaluminate and fluorozirconate glass showed only small index changes of about 2.0/spl times/10/sup -6/ and 2.6/spl times/10/sup -6/ at a wavelength of 1550 nm.
Hemangiopericytoma of bone (1988)

Primary hemangiopericytoma of bone is a rare malignant tumor. Forty-one cases from the literature were reviewed, and four additional cases are reported. The peak incidence is in fourth and fifth decades. The pelvis and lower extremities are the most common locations. The radiographic features are nonspecific, although angiography may aid in the diagnosis. Based on a limited number of evaluable cases, the prognosis seems to correlate with the histologic grade of the tumor. Late recurrence and distant metastases are common.
Organic Chemistry : A Short Course (2006)

Offering practical, real-life applications, coverage of basic concepts, and an engaging visual style, this proven book offers a writing style, approach, and selection of topics ideal for non-chemistry science majors. This edition offers an updated, dynamic art program (online, on CD, and in the text), new content to keep you current with developments in the organic chemistry field, and a revised lab manual. Benefits: NEW! OWL INTEGRATION. Improve student learning outcomes with OWL, the #1 online homework and learning system for chemistry. Developed by chemistry instructors for teaching chemistry, OWL includes course management tools that make homework management a breeze, as well as advanced reporting and grade book features that save time in grading homework and tracking student progress. OWL enables you to address students' different learning styles through tutorials, simulations, visualization exercises, and algorithmically-generated homework questions with answer-specific feedback. With OWL's mastery learning approach, students work at their own pace until they understand each concept/skill. OWL includes an eBook, enhanced with multimedia learning tools. ACCOMPANYING LABORATORY MANUAL. Developed with the assistance of co-author T.K. Vinod at Western Illinois University, the lab manual includes an experiment on green chemistry, pre-laboratory exercises, and safety instructions to students. NEW! INTEGRATION WITH THE LEADING ONLINE HOMEWORK AND TUTORIAL SYSTEM. OWL's step-by-step tutorials, interactive simulations, and homework questions with instant question-specific feedback help you every step of the way as you master tough chemistry concepts and skills. OWL encourages you to learn at your own pace, ensuring that you've mastered each concept before you move on. OWL includes an e-version of your textbook, enhanced with rich multimedia learning tools and available 24/7 in OWL. NEW! NEW PROBLEMS AND SOLUTIONS. This edition offers
Selenoprotein Levels in Patients With Colorectal Adenomas and Cancer (2002)

The present data suggest that patients with adenomatous colon polyps and those with colorectal cancer are not selenium deficient.
Inverse Least-Squares Modeling of Vapor Descriptors Using Polymer-Coated Surface Acoustic Wave Sensor Array Responses (2001)

In previous work, it was shown that, in principle, vapor descriptors could be derived from the responses of an array of polymer-coated acoustic wave devices. This new chemometric classification approach was based on polymer/vapor interactions following the well-established linear solvation energy relationships (LSERs) and the surface acoustic wave (SAW) transducers being mass sensitive. Mathematical derivations were included and were supported by simulations. In this work, an experimental data set of polymer-coated SAW vapor sensors is investigated. The data set includes 20 diverse polymers tested against 18 diverse organic vapors. It is shown that interfacial adsorption can influence the response behavior of sensors with nonpolar polymers in response to hydrogen-bonding vapors; however, in general, most sensor responses are related to vapor interactions with the polymers. It is also shown that polymer-coated SAW sensor responses can be empirically modeled with LSERs, deriving an LSER for each individual sensor based on its responses to the 18 vapors. Inverse least-squares methods are used to develop models that correlate and predict vapor descriptors from sensor array responses. Successful correlations can be developed by multiple linear regression (MLR), principal components regression (PCR), and partial least-squares (PLS) regression. MLR yields the best fits to the training data, however cross-validation shows that prediction of vapor descriptors for vapors not in the training set is significantly more successful using PCR or PLS. In addition, the optimal dimension of the PCR and PLS models supports the dimensionality of the LSER formulation and SAW response models.
A neural network model for survival data (1995)

Abstract Neural networks have received considerable attention recently, mostly by non‐statisticians. They are considered by many to be very promising tools for classification and prediction. In this paper we present an approach to modelling censored survival data using the input—output relationship associated with a simple feed‐forward neural network as the basis for a non‐linear proportional hazards model. This approach can be extended to other models used with censored survival data. The proportional hazards neural network parameters are estimated using the method of maximum likelihood. These maximum likelihood based models can be compared, using readily available techniques such as the likelihood ratio test and the Akaike criterion. The neural network models are illustrated using data on the survival of men with prostatic carcinoma. A method of interpreting the neural network predictions based on the factorial contrasts is presented.
Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer (2009)

Nanoscale carriers are of increasing interest for use in anticancer therapy because they can deliver drugs in a targeted way. Ideally, nanocarriers combine passive and active delivery mechanisms, by integrating targeting ligands on the surface of their stealth corona using simple and efficient conjugation chemistry. This feature article summarizes the conventional and newly explored conjugation chemistries that are used to bind ligands in organic nanoparticle systems, providing strategic guidance for the preparation of targeted nanocarriers.
A computational design tool for compliant mechanisms (2017)

We present a computational tool for designing compliant mechanisms. Our method takes as input a conventional, rigidly-articulated mechanism defining the topology of the compliant design. This input can be both planar or spatial, and we support a number of common joint types which, whenever possible, are automatically replaced with parameterized flexures. As the technical core of our approach, we describe a number of objectives that shape the design space in a meaningful way, including trajectory matching, collision avoidance, lateral stability, resilience to failure, and minimizing motor torque. Optimal designs in this space are obtained as solutions to an equilibrium-constrained minimization problem that we solve using a variant of sensitivity analysis. We demonstrate our method on a set of examples that range from simple four-bar linkages to full-fledged animatronics, and verify the feasibility of our designs by manufacturing physical prototypes.
A closed-loop approach to efficient and stable supply-chain coordination in complex stochastic manufacturing systems (2001)

Modern manufacturing productivity and competitiveness is undoubtedly time-based. As a result, the design of production facilities (product cells) and their operation (just in time, zero in process, lean etc. (R. Suri, 1998; K. Suzaki, 1987)) aim at reducing lead times and inventories of either work in process or finished goods. The MRP practice is a serious impediment to further productivity gains. Indeed, significant gains are possible when lead time dynamics of individual supply chain links are accounted for in the overall manufacturing supply chain coordination through synergistic decentralized production planning. Better production planning algorithms that exploit information sharing are capable of taking the industry to the next big step in productivity gains. The paper argues that time scale decomposition for enhanced information sharing and better deterministic fluid model approximations capturing the essence of the underlying stochastic dynamics can indeed provide these productivity gains.
Combined Effect of Pulmonary Vein Isolation and Ablation of Cardiac Autonomic Nerves for Atrial Fibrillation (2008)

This study was designed to determine whether endocardial high-frequency stimulation at the pulmonary vein (PV) antrums can localize cardiac autonomic ganglionated plexi (GP) and whether ablation at these sites can evoke a vagal response and provide a long-term benefit after PV isolation (PVI) for atrial fibrillation (AF). Radiofrequency ablation of each PV antrum was performed in 21 patients with paroxysmal AF (n = 17) or persistent (n = 4) AF. In 8 patients with paroxysmal AF, a ring electrode catheter was placed at each PV antrum. High-frequency stimulation prolonged the R-R interval in 6 of 8 patients at the left superior (LS) PV, in 3 of 8 patients at the left inferior (LI) PV, in 3 of 8 patients at the right superior (RS) PV, and in 3 of 8 patients at the right inferior (RI) PV. A decrease in sinus rate > 20% was observed in 4 of 21 patients during LS PVI, in 2 of 21 patients during RS PVI, and in 1 of 2 patients during RI PVI. Atrioventricular block or a > 5 second pause was observed in 5 of 21 patients during LS PVI. AF recurred during the follow-up period in 5 of the 16 patients (31%) who had no atrioventricular block or > 5 second pause during PVI but did not recur in 5 patients in whom atrioventricular block or a > 5 second pause developed during PVI. GP can be identified by endocardial stimulation. The AF recurrence rate is decreased when a vagal response is achieved by radiofrequency ablation.
Body temperature rhythm and control of the time of the best physical condition by performing physical labor (2016)

The initial examination of a male subject's body temperature revealed that it was highest during the evening. Based on this observation, I measured grasping power, calculation speed, performance time on a light sensory task and body temperature, all of which were highest or best during the evening. The time of this subject's best physical condition shifted from the evening to morning hours when the subject executed hard physical labor in the morning, and the shifted phase was maintained after the termination of the labor period.
Precise determination of force microscopy cantilever stiffness from dimensions and eigenfrequencies (2012)

We demonstrate the non-destructive measurement of the stiffness of single-beam, monocrystalline silicon cantilevers with a trapezoidal cross-section and tips as used for atomic force microscopy from the knowledge of cantilever dimensions, eigenfrequencies and material parameters. This yields stiffness values with an uncertainty of ±25% as the result critically depends on the thickness of the cantilever that is experimentally difficult to determine. The uncertainty is reduced to ±7% when the measured fundamental eigenfrequency is included in the calculation and a tip mass correction is applied. The tip mass correction can be determined from the eigenfrequencies of the fundamental and first harmonic modes. Results are verified by tip destructive measurements of the stiffness with a precision instrument recording a force–bending curve yielding an uncertainty better than ±5%.