gebhart/patrepeval huggingface dataset:
Reduced expression of cell cycle regulator p18INK4C in human hepatocellular carcinoma (2004)

Cyclins, cyclin-dependent kinases (Cdks), and Cdk inhibitors (CdkIs) are frequently altered in human cancer. p18INK4C, a member of the INK4 family of CdkIs, is a potential tumor-suppressor gene product. However, the expression of p18INK4C in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to examine the expression of p18INK4C in various liver diseases including HCC and to assess its clinical significance in HCC. To that end, we examined the expression of p18INK4C by immunohistochemistry in various liver diseases, including 51 HCCs, and also studied the relationship between p18INK4C expression, the phosphorylation of retinoblastoma protein (pRb), and the activity level of Cdk4 and Cdk6. Immunohistochemical analysis revealed the frequent loss of p18INK4C expression in HCC, especially in poorly differentiated HCC. The loss of p18INK4C expression was shown to be associated with a poor prognosis compared with that associated with p18INK4C- positivity. Further, the kinase activity of Cdk4 was found to be higher in p18INK4C-negative HCCs than in p18INK4C- positive HCCs. However, the level of Cdk6 activity was similar in the 2 groups of HCCs. In p18INK4C- positive HCCs, p18INK4C dominantly interacted with Cdk4 rather than with Cdk6. pRb phosphorylated at serine(Ser) 780 was detected more frequently in p18INK4C - negative than in p18INK4C - positive HCCs. In conclusion, the loss of p18INK4C expression may play a role in the differentiation and development of HCC through the up-regulation of Cdk4 activity.
Contrast-enhanced MR imaging as a prognostic indicator of breast cancer (1998)

These observations suggest that contrast enhancement at MR imaging may be influenced by factors that have prognostic value. If this assumption is correct, contrast-enhanced MR imaging may become a valuable prognostic tool in the pre-operative evaluation of breast cancers.
Extending the scope of OTN to access and metro networks (2017)

Network based on OTN standard (ITU-T G.709), originally devised for core networks, are foreseen to play an important role also in metro and possibly access optical networks, because of the always increasing bandwidth needs as well as of some new (at least numerically) requirements like latency and jitter control. In a historical timeframe in which the standardization activity is primarily focused on the extension of the hierarchy beyond 100 Gb/s, in this paper we quickly recap the basics of OTN, some more recent standard trends, and describe a couple of access and metro applications to which the technology can be easily adapted, both for evolving legacy services, which still exist, to new transmission platforms and for delivering new 5G oriented services.
The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis (2021)

Patients with Parkinson's disease (PD) were often observed with gastrointestinal symptoms, which preceded the onset of motor symptoms. Neuropathology of PD has also been found in the enteric nervous system (ENS). Many studies have reported significant PD-related alterations of gut microbiota. This meta-analysis was performed to evaluate the differences of gut microbiota between patients with PD and healthy controls (HCs) across different geographical regions. We conducted a systematic online search for case-control studies detecting gut microbiota in patients with PD and HCs. Mean difference (MD) and 95% confidence interval (CI) were calculated to access alterations in the abundance of certain microbiota families in PD. Fifteen case-control studies were included in this meta-analysis study. Our results showed significant lower abundance levels of <i>Prevotellaceae</i> (MD = -0.37, 95% CI = -0.62 to -0.11), <i>Faecalibacterium</i> (MD = -0.41, 95% CI: -0.57 to -0.24), and <i>Lachnospiraceae</i> (MD = -0.34, 95% CI = -0.59 to -0.09) in patients with PD compared to HCs. Significant higher abundance level of <i>Bifidobacteriaceae</i> (MD = 0.38, 95%; CI = 0.12 to 0.63), <i>Ruminococcaceae</i> (MD = 0.58, 95% CI = 0.07 to 1.10), <i>Verrucomicrobiaceae</i> (MD = 0.45, 95% CI = 0.21 to 0.69), and <i>Christensenellaceae</i> (MD = 0.20, 95% CI = 0.07 to 0.34) was also found in patients with PD. Thus, shared alterations of certain gut microbiota were detected in patients with PD across different geographical regions. These PD-related gut microbiota dysbiosis might lead to the impairment of short-chain fatty acids (SCFAs) producing process, lipid metabolism, immunoregulatory function, and intestinal permeability, which contribute to the pathogenesis of PD.
Study on Initial Stages of Formation and Growth of Aged &omega;-Phase Crystals in a Ti-15 mass%Mo Alloy using an Analytical Electron Microscope (2003)

Clarification of onset time of formation and formation behaviour of aged ω-phase crystals from as-quenched ω-phase crystals is essential to understand β-ω phase transformation in β-Ti and Zr alloys. The onset time and the formation behaviour in a Ti-15 mass%Mo alloy due to aging at 323 K has been investigated using in-situ observation of morphology change of ω-phase crystals, and EDS analysis of Mo contents in ω-phase crystals and their surrounding matrices. It is found that the difference of Mo contents between as-quenched ω-phase crystals and their surrounding matrices is hardly detected. The onset time determined by the Mo contents analysis is 25.2 ks, which is shorter than that determined by the morphology change observations. Aged ω-phase crystals grow at as-quenched ω-phase crystals. Due to aging at 373 K for 54 ks and at 423 K for 21.6 ks, the growth of aged ω-phase crystals was observed, and these results suggest that aged ω-phase crystals grow due to Ostwalt ripening mechanism.
The History of Goal-Directed Therapy and Relevance to Cardiopulmonary Bypass (2015)

Goal-directed therapy is a patient care strategy that has been implemented to improve patient outcomes. The strategy includes aggressive patient management and monitoring during a period of critical care. Goal-directed therapy has been adapted to perfusion and has been designated goal-directed perfusion (GDP). Since this is a new concept in perfusion, the purpose of this study is to review goal-directed therapy research in other areas of critical care management and compare that process to improving patient outcomes following cardiopulmonary bypass. Various areas of goaldirected therapy literature were reviewed, including fluid administration, neurologic injury, tissue perfusion, oxygenation, and inflammatory response. Data from these studies was compiled to document improvements in patient outcomes. Goal-directed therapy has been demonstrated to improve patient outcomes when performed within the optimal time frame resulting in decreased complications, reduction in hospital stay, and a decrease in morbidity. Based on the successes in other critical care areas, GDP during cardiopulmonary bypass would be expected to improve outcomes following cardiac surgery.
Iterative sequential multiuser receiver for asynchronous coded CDMA systems over frequency-selective fading channels (2004)

This paper investigated a reduced complexity iterative multiuser detector based on sequential sequence estimation technique for joint detection and decoding of asynchronous code division multiple access (CDMA) signals over frequency-selective fading channels. The soft-input soft-output (SISO) multiuser detector is realized by the soft-output sequential algorithm (SOSA), previously introduced for turbo equalization systems. The advantage of this scheme comes from the low complexity of the sequential algorithm, which is only linearly dependent on the number of users. Simulation results show that the iterative sequential multiuser detector can achieve a significant performance gain over the conventional single-user detector as well as the multistage interference cancellation (MIC) receiver, and that it suffers a small amount of degradation compared with the single user performance.
Elimination of platinum inclusions in phosphate laser glasses (1989)

Results from small-scale glass melting experiments aimed at reducing the density of platinum particles in phosphate laser glasses are discussed. The platinum particles originate from the crucibles used to melt the laser glass and can cause optical damage in glasses used in high-peak-power lasers; this problem was particularly acute in the LLNL 120 kJ, 100 TW Nova laser. The melting experiments examine the effects of (i) N{sub 2}, O{sub 2}, and Cl{sub 2} gas atmospheres; (ii) temperature and temperature gradients; (iii) processing time; and (iv) platinum alloys on the formation and dissolution of platinum inclusions in LHG-8 and LG-750 phosphate laser glasses. Results show that most platinum inclusions originate early in the melt cycle, with thermal gradients within the melter being one of the major causes. By using oxidizing gas conditions (O{sub 2}, Cl{sub 2}, or O{sub 2} + Cl{sub 2}), the platinum inclusions can be dissolved into the glass during the course of the melt cycle. The dissolution rate of platinum under oxidizing conditions has been measured, and a model is used to quantify the description of the dissolution process. The effect of ionic platinum on the transmission spectra of the laser glasses produced under various oxidizing conditions has also been measured. Results from the above laboratory-scale melting experiments have been incorporated into proprietary laser-glass melting processes. The laser glasses prepared under these conditions have an average of less than 0.1 platinum inclusions/liter, which represents a 1000-fold reduction over the previously available phosphate laser glasses. 52 refs., 56 figs., 15 tabs.
An efficient technique for deriving receiver filters in multiuser asynchronous DS/SSMA (2002)

It has been shown that the performance of sub-optimal multiuser receivers for synchronous DS/SSMA is improved by using a noise whitening matched filter (WMF) as a receiver filter. In the asynchronous case the performance is also improved through the use of a WMF. We present an efficient technique for deriving the WMF for an asynchronous DS/SSMA system. The WMF is determined as the Cholesky decomposition of X where X is the solution to X=R/sub 0/-R/sub 1//sup T/X/sup -1/R/sub 1/. A recursive algorithm for determining X is proposed. Constraints on the spreading codes that ensure convergence of the algorithm are derived and the efficiency of the technique is demonstrated by simulation.
Organic liquid mixtures separation by permselective polymer membranes. 1. Selection and characteristics of dense isotropic membranes employed in the pervaporation process (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic liquid mixtures separation by permselective polymer membranes. 1. Selection and characteristics of dense isotropic membranes employed in the pervaporation processIsrael CabassoCite this: Ind. Eng. Chem. Prod. Res. Dev. 1983, 22, 2, 313–319Publication Date (Print):June 1, 1983Publication History Published online1 May 2002Published inissue 1 June 1983https://pubs.acs.org/doi/10.1021/i300010a029https://doi.org/10.1021/i300010a029research-articleACS PublicationsRequest reuse permissionsArticle Views422Altmetric-Citations112LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Transducers, sensors & detectors (1983)

Transducers, sensors & detectors , Transducers, sensors & detectors , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Adaptive equalization with neural networks: new multi-layer perceptron structures and their evaluation (1992)

Nonlinear equalizers find use in communication applications where the channel distortion is too severe for a linear equalizer to handle. Because of their nonlinear capability and other attractive properties, neural networks have become appealing candidates for equalization problems. The application of neural networks to adaptive equalization problems is investigated. In particular, realization structures (MLP-I, MLP-II) of a multilayer perceptron (MLP) with a backpropagation training algorithm are introduced, and it is shown that they work well for both PAM and QAM signals of any constellation size (e.g., 4-PAM, 8-PAM, 16-QAM, and 64-QAM). It is demonstrated that both MLP structures outperform the least mean square (LMS)-based linear equalizer when channel distortions are nonlinear.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
UNIFAC parameter table for prediction of liquid-liquid equilibriums (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUNIFAC parameter table for prediction of liquid-liquid equilibriumsThomas Magnussen, Peter Rasmussen, and Aage FredenslundCite this: Ind. Eng. Chem. Process Des. Dev. 1981, 20, 2, 331–339Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/i200013a024https://doi.org/10.1021/i200013a024research-articleACS PublicationsRequest reuse permissionsArticle Views5215Altmetric-Citations727LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Influence of Aqueous-Phase Ionic Strength and Composition on the Dynamics of Water–Crude Oil Interfacial Film Formation (2016)

In this paper, we examine the impact of aqueous-phase ionic strength and ionic composition on viscoelastic properties of the water–crude oil interfacial film by conducting interfacial shear rheological measurements under controlled water chemistry and aging time. A double-wall ring geometry is used in oscillatory mode to measure the film viscoelastic moduli. To further elucidate mechanisms controlling the kinetics of film formation, temperature-dependent interfacial rheological behavior is investigated as a function of time. Our results reveal that low-ionic-strength conditions are more conducive to film formation and, consequently, engender a more viscoelastic interface. This observation is consistent with our previous results on emulsion stability; i.e., increasing the ionic strength of the aqueous phase leads to the formation of less stable emulsions. On the other hand, the temperature dependence of the viscoelasticity buildup demonstrates that adsorption of polar materials onto the interface can be modeled as a diffusion-controlled process, affected by the temperature in two different ways: first, through viscosity temperature dependence and, second, directly through the diffusivity dependence. Our results provide insights into emulsion stability mechanisms as well as multiphase fluid interfacial processes.
A Coreless Electric Current Sensor With Circular Conductor Positioning Calibration (2013)

This paper presents a novel coreless current sensor unit for measuring electrical current of circular conductors. The proposed sensor unit consists of three magnetic field sensors and a microcontroller unit (MCU). The new sensor unit does not need a bulky magnetic core necessary for magnetic field concentration, and can be used in the same way as conventional current transformers (CTs). An algorithm is developed to calibrate the outputs of the magnetic field sensors (e.g., Hall effect integrated circuits (ICs) with respect to the relative position of the current-carrying circular conductor. The algorithm can be implemented on a low-cost MCU for automatic real-time operation. Unlike other coreless magnetic field sensors that need to be fixed onto the conductor for accurate current measurement, the proposed sensor unit affords a more flexible installation option. A hardware prototype is constructed for the proposed coreless current sensor unit. The performance evaluation results show that the accuracy of the proposed sensor unit is comparable to the conventional magnetic core CTs.
Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements (2013)

Quantitative bioanalytical measurements are commonly performed in a kinetic format and are known to not be robust to perturbation that affects the kinetics itself or the measurement of kinetics. We hypothesized that the same measurements performed in a "digital" (single-molecule) format would show increased robustness to such perturbations. Here, we investigated the robustness of an amplification reaction (reverse-transcription loop-mediated amplification, RT-LAMP) in the context of fluctuations in temperature and time when this reaction is used for quantitative measurements of HIV-1 RNA molecules under limited-resource settings (LRS). The digital format that counts molecules using dRT-LAMP chemistry detected a 2-fold change in concentration of HIV-1 RNA despite a 6 °C temperature variation (p-value = 6.7 × 10(-7)), whereas the traditional kinetic (real-time) format did not (p-value = 0.25). Digital analysis was also robust to a 20 min change in reaction time, to poor imaging conditions obtained with a consumer cell-phone camera, and to automated cloud-based processing of these images (R(2) = 0.9997 vs true counts over a 100-fold dynamic range). Fluorescent output of multiplexed PCR amplification could also be imaged with the cell phone camera using flash as the excitation source. Many nonlinear amplification schemes based on organic, inorganic, and biochemical reactions have been developed, but their robustness is not well understood. This work implies that these chemistries may be significantly more robust in the digital, rather than kinetic, format. It also calls for theoretical studies to predict robustness of these chemistries and, more generally, to design robust reaction architectures. The SlipChip that we used here and other digital microfluidic technologies already exist to enable testing of these predictions. Such work may lead to identification or creation of robust amplification chemistries that enable rapid and precise quantitative molecular measurements under LRS. Furthermore, it may provide more general principles describing robustness of chemical and biological networks in digital formats.
Extended Regularization Methods for Nonconvergent Model Selection (1992)

Many techniques for model selection in the field of neural networks correspond to well established statistical methods. The method of &apos;stopped training&apos;, on the other hand, in which an oversized network is trained until the error on a further validation set of ex-amples deteriorates, then training is stopped, is a true innovation, since model selection doesn&apos;t require convergence of the training process. In this paper we show that this performance can be significantly enhanced by extending the &apos;non convergent model selection method&apos; of stopped training to include dynamic topology modifications (dynamic weight pruning) and modified complexity penalty term methods in which the weighting of the penalty term is adjusted during the training process. 1
Automated discovery of functional components of proteins from amino-acid sequences based on rough sets and change of representation (1995)

Protein structure analysis from DNA sequences is an important and fast growing area in both computeT science and biochemistry. Although interesting ap-proaches have been studied, it is very dificult to cap-ture the characteristics of protein, since even a sim-ple protein are made of more than 100 amino acids, which makes biochemical experiments very dificult to detect functional components. For this reason, almost all the problems in this field are left unsolved and it is very important to develop a system which assists researchers on molecular biology to remove the difi-culties caused by combinatorial explosions. In this pa-per we report a system, called MWI (Molecular biol-ogists ’ Workbench version l.O), which extracts knowl-edge from amino-acid sequences by controlling appli-cation of domain knowledge automatically. We apply this method to comparative analysis of lysozyme and LX-lactalbumin. The results show that we obtain several interesting results from amino-acid sequences, which have not been reported before. 1.
ChemInform Abstract: SYNTHESIS AND ANTICONVULSANT TESTING OF 4‐PHENYLSEMICARBAZIDES (1984)

Abstract Zur Untersuchung der antikonvulsiven Wirkung werden die Semicarbazide (III) durch Reaktion der Arylisocyanate (I) mit den disubstituierten Hydrazinen (II) hergestellt.
Chemotaxis of Capacitated Rabbit Spermatozoa to Follicular Fluid Revealed by a Novel Directionality-Based Assay1 (2002)

Precontact communication between gametes is established by chemotaxis. Sperm chemotaxis toward factor(s) in follicular fluid (FF) has been demonstrated in humans and mice. In humans, the chemotactic responsiveness is restricted to capacitated spermatozoa. Here, we investigated whether sperm chemotaxis to factor(s) present in FF also occurs in rabbits and, if so, whether only capacitated spermatozoa are chemotactically responsive. Chemotaxis assays were performed by videomicroscopy in a Zigmond chamber. We measured chemotactic responsiveness as a function of FF dilution by means of a novel directionality-based method that considers the ratio between the distances traveled by the spermatozoa both parallel to the chemoattractant gradient and perpendicular to it. A peak of maximal response was observed at 10(-4) dilution of FF, resulting in a typical chemotactic concentration-dependent curve in which 23% of the spermatozoa were chemotactically responsive. In contrast, the percentage of cells exhibiting FF-dependent enhanced speed of swimming increased with the FF concentration, whereas the percentage of cells maintaining linear motility decreased with the FF concentration. The percentages of chemotactically responsive cells were very similar to those of capacitated spermatozoa. Depletion of the latter by stimulation of the acrosome reaction resulted in a total loss of the chemotactic response, whereas the reappearance of capacitated cells resulted in a recovery of chemotactic responsiveness. We conclude that rabbit spermatozoa, like human spermatozoa, are chemotactically responsive to FF factor(s) and acquire this responsiveness as part of the capacitation process.