gebhart/patrepeval huggingface dataset:
Structures Related to Morphine. XXV.<sup>1a</sup> 5-Propyl- and 5,9-Dipropyl-6,7-benzomorphans and a Pharmacologic Summary<sup>1b</sup> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures Related to Morphine. XXV.1a 5-Propyl- and 5,9-Dipropyl-6,7-benzomorphans and a Pharmacologic Summary1bJ. Harrison Ager, S. E. Fullerton, and Everette L. MayCite this: J. Med. Chem. 1963, 6, 3, 322–325Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/jm00339a025https://doi.org/10.1021/jm00339a025research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DETERMINANTS OF GRAFT SURVIVAL AFTER RENAL TRANSPLANTATION1 (1996)

We studied multiple determinants of graft survival at a single center and the effects of nonimmunologic graft loss on transplant survival. This retrospective study examined the results of 589 cadaver donor transplants performed between 1986 and 1992. Graft survival rates were calculated using Kaplan-Meier estimates for both overall graft survival (all causes of graft loss) and immunologic graft survival (function lost due to acute or chronic rejection and noncompliance). Cadaver graft survival was significantly poorer with an increasing degree of DR mismatch (P=0.02). An analysis of pretransplant variables showed graft loss risk was highest with greater DR mismatches, two B-antigen mismatch, higher donor serum creatinine, and younger recipient age. After transplantation, acute rejection was the most significant factor associated with long-term graft survival. Our data demonstrate a significant advantage for zero DR and one DR mismatch cadaver donor transplants, with excellent immunologic graft survival. This study suggests that a combination of immediate graft function, prevention of acute rejection by appropriate early immunosuppressive therapy, and acceptable DR match enhances cadaveric graft survival.
Outcomes of an emergent literacy intervention in Head Start. (1994)

Classrooms of 4-year-olds attending Head Start were randomly assigned to an intervention condition, involving an add-on emergent literacy curriculum, or a control condition, involving the regular Head Start curriculum. Children in the intervention condition experienced interactive book reading at home and in the classroom as well as a classroom-based sound and letter awareness program. Children were pretested and posttested on standardized tests of language, writing, linguistic awareness, and print concepts
Cooperative Asymmetric Catalysis with Dendrimeric [Co(salen)] Complexes (2000)

Dendrimeric catalysts can present catalytic units in close proximity, thereby inducing useful cooperative effects (see picture). Commercial dendrimers were derivatized with chiral [Co(salen)] complexes and found to display enhanced reactivity relative to monomeric or even dimeric analogues in the hydrolytic kinetic resolution of epoxides.
Alternative municipal wireless network models Examination of grassroots and ad-based initiatives (2008)

This research explores the various solutions currently available for sharing Wi-Fi connections and seek to identify whether there are potential applications and business models that could be used to make such grass root and advertising-based deployments a viable alternative to the capital intensive wireless infrastructures offered by the dominant network integration players (e.g., Cisco, HP, IBM, Motorola, etc.) in the wireless community market.
Mast Cell Migratory Response to Interleukin-8 Is Mediated Through Interaction With Chemokine Receptor CXCR2/Interleukin-8RB (1999)

To explore the role of chemokines in mast cell chemotaxis and accumulation at sites of inflammation, we first investigated the response of human mast cells to 18 different chemokines by induction of intracellular calcium mobilization in the human mast cell line, HMC-1. Only a subgroup of CXC chemokines defined by the conserved sequence motif glutamic acid-leucine-arginine (ELR) tripeptide motif, which included interleukin-8 (IL-8), growth-regulated oncogene alpha (GROalpha), neutrophil-activating peptide-2 (NAP-2), and epithelial cell-derived neutrophil activating peptide-78 (ENA-78), induced calcium flux in the cells. These observations suggested that the receptor CXCR2 (IL-8RB) should be expressed on the surface of these cells. Using the RNAse protection assay, CXCR2 mRNA, but not CXCR1 (IL-8RA) mRNA expression was detected in HMC-1 cells. Flow cytometry analysis documented the surface expression of CXCR2. A binding analysis performed with 125I-IL-8 determined that there were approximately 3,600 high affinity IL-8 binding sites per HMC-1 cell, with a calculated kd of 1.2 to 2 nmol/L. The activity of this receptor was further explored using IL-8, which was found to induce dose-dependent chemotactic and haptotactic responses in both HMC-1 cells and in vitro cultured human cord blood-derived mast cells. These results show the expression of functional CXCR2 receptors on the surface of human mast cells, which may play an important role in mast cell recruitment during the genesis of an inflammatory response.
Interaction of Molecular Oxygen with a Magnetic Field (1955)

The dominant interaction of ${\mathrm{O}}_{2}$ with a magnetic field is through the electronic spin magnetic moment. However, a precise comparison with experiment of the results of calculating the microwave paramagnetic spectrum, assuming only this interaction, shows a systematic discrepancy. This discrepancy is removed by introducing two corrections. The larger (approximately 0.1 percent, or 7 gauss) is a correction for the second-order electronic orbital moment coupled in by the spin-orbit energy. Its magnitude is proportional to the second-order term ${\ensuremath{\mu}}^{\ensuremath{'}\ensuremath{'}}$ in the spin-rotation coupling constant. The smaller (approximately 1 gauss) is a correction for the rotation-induced magnetic moment of the molecule. Since the dependence of this contribution on quantum numbers is quite unique, this coefficient can also be determined by fitting the magnetic spectrum. A total of 120 $X$-band and 78 $S$-band lines were observed. The complete corrections have been made on 26 lines with a mean residual error of roughly 0.5 Mc/sec. This excellent agreement confirms the anomalous electronic moment to 60 parts per million (ppm) and also confirms the validity of the Zeeman-effect theory.A new result is the rotational magnetic moment of -0.25\ifmmode\pm\else\textpm\fi{}0.05 nuclear magnetons per quantum of rotation. Knowledge of this moment allows the electronic contribution to the effective moment of inertia to be determined. Making this correction of 65 ppm, and using the latest fitting of the universal atomic constants, the equilibrium internuclear distance is recomputed to be ${R}_{e}=1.20741\ifmmode\pm\else\textpm\fi{}0.00002$ A. We can also deduce that the magnitude of ${\ensuremath{\lambda}}^{\ensuremath{'}\ensuremath{'}}$, the second-order spin-orbit contribution to the coupling of the spin to the figure axis, is 465\ifmmode\pm\else\textpm\fi{}50 Mc/sec, or less than one percent of the total coupling constant $\ensuremath{\lambda}$.Theoretical intensities of a number of the microwave transitions are calculated and successfully compared with experiment over a range of 100 to 1 in magnitude. It turns out that $\ensuremath{\Delta}M=0$ transitions are over a hundred times weaker than the $\ensuremath{\Delta}M=\ifmmode\pm\else\textpm\fi{}1$ transitions and thus are too weak to observe. Also, $J$ breaks down as a quantum number in the presence of a magnetic field. This allows $\ensuremath{\Delta}J=\ifmmode\pm\else\textpm\fi{}2$ transitions to comprise roughly half of all lines observed.
Alternative tertiary structure attenuates self-cleavage of the ribozyme in the satellite RNA of barley yellow dwarf virus (1991)

A self-cleaving satellite RNA associated with barley yellow dwarf virus (sBYDV) contains a sequence predicted to form a secondary structure similar to catalytic RNA molecules (ribozymes) of the 'hammerhead' class (Miller et al., 1991, Virology 183, 711-720). However, this RNA differs from other naturally occurring hammerheads both in its very slow cleavage rate, and in some aspects of its structure. One striking structural difference is that an additional helix is predicted that may be part of an unusual pseudoknot containing three stacked helices. Nucleotide substitutions that prevent formation of the additional helix and favor the hammerhead increased the self-cleavage rate up to 400-fold. Compensatory substitutions, predicted to restore the additional helix, reduced the self-cleavage rate by an extent proportional to the calculated stability of the helix. Partial digestion of the RNA with structure-sensitive nucleases supported the existence of the proposed alternative structure in the wildtype sequence, and formation of the hammerhead in the rapidly-cleaving mutants. This tertiary interaction may serve as a molecular switch that controls the rate of self-cleavage and possibly other functions of the satellite RNA.
Handling Noise in Boolean Matrix Factorization (2017)

We critically examine and point out weaknesses of the existing considerations in Boolean matrix factorization (BMF) regarding noise and the algorithms' ability to deal with noise. We argue that the current understanding is underdeveloped and that the current approaches are missing an important aspect. We provide a new, quantitative way to assess the ability of an algorithm to handle noise. Our approach is based on a common-sense definition of robustness requiring that the computed factorizations should not be affected much by varying the noise in data. We present an experimental evaluation of several existing algorithms and compare the results to the observations available in the literature. In addition to providing justification of some properties claimed in the literature without proper justification, our experiments reveal properties which were not reported as well as properties which counter certain claims made in the literature. Importantly, our approach reveals a line separating robust-to-noise from sensitive-to-noise algorithms, which has not been revealed by the previous approaches.
Determination of the Velocity Vector of Point Retroreflectors by Spatial Filtering of Doppler Spectra (1971)

A method for determining the velocity vector of coherently illuminated point retroreflectors moving with velocity upsilon (s) in the focal region of the collecting lens of an optical heterodyne receiver from the doppler spectrum is examined. Information relating to the magnitude and direction of upsilon (s) is shown to be obtainable by introducing a rotating mask in the signal or detector arm of the heterodyne receiver. The significance of the configuration examined as a model for widely dispersed multielement doppler radar systems is briefly discussed.
Preface: Alternative Routes to Teacher Certification (2017)

A growing research literature on non-traditional pathways suggests the complexity of the task ahead. Alternative Routes to Teacher Certification is our report from the front lines. We wanted to offer new teachers the opportunity to tell their own stories in their own words.
Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development (2008)

Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.
Increased synthesis of DnaK, GroEL, and GroES homologs by Francisella tularensis LVS in response to heat and hydrogen peroxide (1994)

The response of the facultative intracellular bacterium Francisella tularensis LVS to stress was assayed by pulse-labeling with [35S]methionine followed by two-dimensional gel electrophoresis and autoradiography. A temperature increase from 37 to 42 degrees C or exposure to 5 mM hydrogen peroxide induced increased syntheses of at least 15 proteins. Among these proteins were a 75-, a 60-, and a 10-kDa protein. By N-terminal sequence analysis, these three proteins were found to be extensively homologous to the highly conserved chaperone proteins DnaK, GroEL, and GroES of Escherichia coli. Antibodies specific to the DnaK homolog of E. coli reacted with the 75-kDa protein, and antibodies to the GroEL homolog of Legionella micdadei reacted with the 60-kDa protein. A readiness to respond to hydrogen peroxide with synthesis of the chaperone components may be fundamental to the intracellular survival of pathogens such as F. tularensis, which are exposed to oxidative stress while invading the host macrophages.
Validating the Numerical Prediction of the Aerodynamics of an Axial Compressor (2014)

Numerical methods have become the basis for the aerodynamic design of turbomachinery in order to reduce the time for development cycles and associated cost. Designing modern axial compressors requires high confidence in the quality of numerical predictions. In terms of the aerodynamics, the loading of the blades as well as the efficiency targets constantly increase. Losses have to be predicted precisely and the impact of three-dimensional secondary flows, separation, and laminar-turbulent transition must be taken into account. In the present paper, the aerodynamic prediction quality of the state-of-the-art turbomachinery design code TRACE is validated against experimental data from a 2.5-stage axial compressor. The aerodynamic prediction quality is systematically investigated to determine errors and uncertainties regarding the discretization, turbulence and transition models, and importance of considering unsteady effects. Computations are performed for several operating points and the results are validated by means of the compressors integral pressure ratio as well as by means of local pneumatic probe measurements. It is shown that using the empirical γ–ReΘ model improves the prediction quality of the boundary layers and wake flows. Time-resolved computations at the design point of the compressor show that the strength and the losses of a corner separation in both vane rows are reduced to realistic levels when the periodic-unsteady interaction with the upstream wakes is considered. The generally good aerodynamic predictions for both local and integral experimental quantities qualify TRACE for aeroelastic predictions which are planned for the future.
Cardiovascular responses to psychological and physiological stressors during the menstrual cycle. (1991)

Psychological and physical stress reactivity was studied in 15 females in two phases of the menstrual cycle (cycle days 5-7 and 24-26) and in 15 males. Each female was matched for age and time between sessions with a male. There was a significant phase-related difference in cardiovascular reactivity among the females. Females in the luteal phase reacted significantly more to the cold pressor but not to the mental arithmetic test. There were significant sex differences in systolic blood pressure, the males displaying higher levels during provocation, as well as during control conditions. The females were more reactive in heart rate to the mental stressor when changes from control conditions to stress were calculated. When the data were analyzed separately for smokers and non-smokers, there was a significant interaction between menstrual cycle phase and smoking. In the luteal phase, the female smokers were more reactive in systolic blood pressure than the non-smokers. The male smokers were more reactive than the non-smokers in diastolic blood pressure response to mental arithmetic, but not to the cold pressor test. Significantly higher levels of cortisol and aldosterone were found in the luteal phase as compared with the follicular phase. The cortisol levels were higher in the males than in the females in the follicular phase, whereas the female aldosterone concentrations in the luteal phase were higher than those of the males.
High-speed measurement of foot shape based on multiple-laser-plane triangulation (2009)

Optical three-dimensional shape measurement of live objects is becoming an important developing and research tool because of its nonintrusive nature and high measuring speed. The current methods are reaching truly high speed in one view configuration, but in the case of the entire object shape measurement, they are limited due to mutual interference between multiple measuring modules. The proposed method overcomes this limitation by using a laser multiple-line triangulation technique, where each of several measuring modules uses a unique laser wavelength. The measuring modules are positioned so that the entire surface of the foot is digitized. This prevents unwanted overlapping between adjacent light patterns. The calibration procedure for each measuring module and for the entire system is based on measurements of the surface of a reference object. The system parameters are determined using an iterative optimization algorithm. The precision of the system is better than ±0.3 mm. The system is capable of measuring objects in motion. The results of the shape of a foot rising on its toes are given as an example.
The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7 (2005)

Toll-like receptor 2 (TLR2) plays an important role in host defense against bacterial pathogens. Activation of TLR2 signaling not only induces the activation of innate immunity and instructs the development of the acquired immunity but also leads to the detrimental inflammatory responses in inflammatory and infectious diseases. To avoid detrimental inflammatory responses, TLR2 signaling must be tightly regulated. In contrast to the relative known positive regulation of TLR2 signaling, its negative regulation, however, is largely unknown. In addition the distal signaling components that link TLR2 to its downstream signaling pathways have yet to be further defined. In the present study we have provided direct evidence for the negative regulation of TLR2 signaling by the tumor suppressor cylindromatosis (CYLD). We showed that activation of TLR2 signaling by TLR2 ligands including peptidoglycan (PGN), MALP-2, and Pam3CSK4 induces activation of IKKs-IkappaBalpha and MKK3/6-p38 pathways not only by TRAF6 but also by TRAF7, a recently identified TRAF family member. The activation of both pathways leads to the transcription of TNF-alpha, IL-1beta, and IL-8 as well as CYLD. CYLD in turn leads to the inhibition of TRAF6 and TRAF7 likely via a deubiquitination-dependent mechanism. The present studies thus unveil a novel autoregulatory feedback mechanism that negatively controls TLR2-IKKs-IkappaBalpha/MKK3/6-p38-NF-kappaB-dependent induction of immune and inflammatory responses via negatively cross-talking with both TRAF6 and TRAF7. These findings provide novel insights into autoregulation and negative regulation of TLR signaling.
Speed control of PIG using bypass flow in natural gas pipeline (2002)

This paper introduces a simple nonlinear control method for pipeline inspection gauge (PIG) flow in a natural gas pipeline. The PIG is controlled using the amount of bypass flow across its body. The dynamic behavior of the PIG depends on the different pressure across its body and the bypass flow through it. The system dynamics includes: dynamics of driving gas flow behind the PIG, dynamics of expelled gas in front of the PIG, dynamics of bypass flow and dynamics of the PIG. The method of characteristics (MOC) and Runge-Kutta method are used to solve the dynamics of flow. To control the PIG velocity, a simple nonlinear controller is proposed based on the back-stepping method. The closed loop system is stable in the sense of Lyapunov stability. To derive such a controller, three system parameters should be measured: the PIG position, its velocity and the velocity of bypass flow across the PIG body. To show the effectiveness of the proposed controller, the simulation has been done with three cases: the PIG starts to move at its launcher, the PIG arrives at its receiver and the PIG restarts after stopping in the pipeline. The simulation results show that the proposed controller can be used for controlling the PIG velocity with good performance when it runs in the natural gas pipeline.
A Histogram-Based Testing Method for Estimating A/D Converter Performance (2008)

A sine-wave histogram-testing structure for analog-to-digital converters (ADCs) is proposed. The ADC static parameters, i.e., offset error, gain error, and nonlinearity errors, are directly obtained from the sine-wave histogram test. Then, the obtained static parameters are related to the estimation of the degraded signal-to-noise ratio (SNR) value. Therefore, the relationships among these parameters are analyzed, and a single sine-wave histogram test can be performed to evaluate the ADC. With the appropriate approximations in the reference sine-wave histograms and the estimations of the ADC parameters, the realization of an ADC output analyzer circuit could be a simple task. An ADC output analyzer circuit is therefore developed and synthesized using a 0.18-mum technique to analyze the outputs of an 8-bit ADC and estimate its performances using the proposed method.
Radioactive Marker Measurements in Heterogeneous Reservoirs: Numerical Study (2004)

A numerical study is performed to simulate the vertical deformation of a depth interval representing a marker spacing (10.5 m) located in a deep heterogeneous sedimentary reservoir. Realistic lithostratigraphic sequences typical of the Northern Adriatic basin are used. A number of scenarios are addressed consistent with the available data. In particular two basic geologic scenarios at the marker scale are simulated, one where sands prevail within the marker spacing (SD), and another where thin sandy and clayey layers alternate (CL). The sensitivity of the marker response is investigated in relation to clay and sand permeability and compressibility contrast, Biot’s coefficient, and respective position of monitoring and fluid pumping wells. The modeling results show that rock may indeed expand above and below depleted layers. Depending on the marker position the expansion may partially offset the compaction, especially in the CL scenario with a very low permeable clay. To obtain a representative field compaction the markers should span a depth interval made mostly by sand and entirely depleted, and should be installed in a test hole far from producing wells. Compressibility contrast and the Biot coefficient play a secondary role. Very critical measurements are provided by two markers which incorporate a thin (≈1 m) depleted level overlain and underlain by almost impermeable clay layers.