gebhart/patrepeval huggingface dataset:
Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo (2009)

The effects of lactobacilli on impaired intestinal barrier function and paracellular permeability were evaluated in human epithelial Caco-2 cells treated with tumor necrosis factor-alpha and in mice with colitis induced by dextran sodium sulfate (DSS). Filter-grown Caco-2 monolayers were used as the intestinal epithelial model. Among the 4 lactobacilli studied, Lactobacillus rhamnosus OLL2838 most effectively suppressed barrier impairment and increased IL-8 secretion induced by tumor necrosis factor-alpha in Caco-2 cells; however, the conditioned medium from OLL2838 did not show any effect on barrier functions. The in vivo effects of OLL2838 on intestinal epithelial barrier function and colonic inflammation were assessed in DSS-induced colitis of BALB/c mice. Oral treatment with both live and heat-killed OLL2838 suppressed weight loss and recovered colon length. Additionally, barrier function was restored by the administration of live and heat-killed OLL2838 to the DSS-treated animals, which conferred protection against the increase in mucosal permeability associated with DSS-induced colitis. This may at least partially be because of the increased expression of zonula occludens-1 (4.8-fold) and myosin light-chain kinase (3.1-fold) in intestinal epithelial cells isolated from mice of the heat-killed OLL2838 group. Therefore, L. rhamnosus OLL2838 would be useful in the treatment of gastrointestinal diseases such as inflammatory bowel disease.
Doped polymer electrodes for high performance ferroelectric capacitors on plastic substrates (2012)

Flexible ferroelectric capacitors with doped polymer electrodes have been fabricated on plastic substrates with performance as good as metal electrodes. The effect of doping on the morphology of polymer electrodes and its impact on device performance have been studied. Improved fatigue characteristics using doped and undoped poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) electrodes versus metal electrodes are observed. It is shown that the polymer electrodes follow classical ferroelectric and dielectric responses, including series resistance effects. The improved device characteristics obtained using highly conducting doped PEDOT:PSS suggest that it may be used both as an electrode and as global interconnect for all-polymer transparent circuits on flexible substrates.
A computational tool for the efficient analysis of dose‐volume histograms for radiation therapy treatment plans (2010)

A Histogram Analysis in Radiation Therapy (HART) program was primarily developed to increase the efficiency and accuracy of dose-volume histogram (DVH) analysis of large quantities of patient data in radiation therapy research. The program was written in MATLAB to analyze patient plans exported from the treatment planning system (Pinnacle 3 ) in the American Association of Physicists in Medicine/Radiation Therapy Oncology Group (AAPM/RTOG) format. HART-computed DVH data was validated against manually extracted data from the planning system for five head and neck cancer patients treated with the intensity-modulated radiation therapy (IMRT) technique. HART calculated over 4000 parameters from the differential DVH (dDVH) curves for each patient in approximately 10-15 minutes. Manual extraction of this amount of data required 5 to 6 hours. The normalized root mean square deviation (NRMSD) for the HART-extracted DVH outcomes was less than 1%, or within 0.5% distance-to-agreement (DTA). This tool is supported with various user-friendly options and graphical displays. Additional features include optimal polynomial modeling of DVH curves for organs, treatment plan indices (TPI) evaluation, plan-specific outcome analysis (POA), and spatial DVH (zDVH) and dose surface histogram (DSH) analyses, respectively. HART is freely available to the radiation oncology community.
The language and rhetoric of quality: Made in the U.S.A. (1987)

Corporate attention to quality products and services is expressed in the language used to communicate that attention. Language that is redundant, intense and elevated to iconic status both reflects and shapes attention. This study examines how end‐users, corporate bodies and employees communicate about quality. A series of propositions are inductively derived.
Effect of thermal radiation on boundary layer flow and heat transfer of dusty fluid over an unsteady stretching sheet (2013)

The aim of this paper is to study the boundary layer flow and heat transfer analysis of an unsteady viscous dusty fluid over a porous stretching surface. Momentum Boundary layer equation considers the effect of transverse magnetic field whereas thermal Boundary layer equation considers the effect of thermal radiation. The governing partial Differential equations are reduced to coupled non-linear ordinary differential equations using similarity transformation. Numerical solutions of these equations are obtained with the help of RKF-45 method. The solution is found to be dependent on different governing parameters. Some important findings reported in this work reveal that the effect of radiation has significant impact in controlling the rate of heat transfer in the boundary layer region.Keywords: Unsteady flow and heat transfer; Boundary layer flow; Stretching porous Surface; Dusty fluid; Thermal radiation; Numerical solution
Amplification of the Transketolase Gene in Desensitization-resistant Mutant Y1 Mouse Adrenocortical Tumor Cells (1996)

As shown previously, mutants of the Y1 mouse adrenocortical tumor cell line that resist agonist-induced desensitization of adenylyl cyclase have elevated levels of a 68-kDa protein (designated p68), suggesting a possible relationship between p68 and the regulation of adenylyl cyclase activity. In the present study, cDNA cloning and sequencing were used to identify p68 as mouse transketolase. Cells overexpressing p68 exhibited a 17.4-fold increase in transketolase enzymatic activity relative to parental Y1 cells and a 28-fold amplification of the transketolase gene as determined by Southern blot hybridization analysis. Using fluorescent in situ hybridization analysis, the transketolase gene was mapped to mouse chromosome 16B1 and to human chromosome 3p21.2. Transketolase gene amplification was associated with telomeric fusion of the chromosome 16 pair together with the appearance of multiple copies of the transketolase gene throughout a different chromosome. The relationship between overexpression of transketolase and desensitization resistance was evaluated in somatic cell hybrids formed between a desensitization-resistant adrenal cell line and a desensitization-sensitive rat glial cell line. In these hybrids, transketolase overexpression behaved dominantly, whereas desensitization resistance behaved recessively. These results dissociate the desensitization resistance phenotype from overexpression of transketolase and suggest that desensitization resistance may have resulted from disruption of an essential regulatory gene in conjunction with the amplification event.
Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms (2018)

Autophagy has been shown to be elevated in pancreatic ductal adenocarcinoma (PDAC), and its role in promoting established tumor growth has made it a promising therapeutic target. However, due to limitations of prior mouse models as well as the lack of potent and selective autophagy inhibitors, the ability to fully assess the mechanistic basis of how autophagy supports pancreatic cancer has been limited. To test the feasibility of treating PDAC using autophagy inhibition and further our understanding of the mechanisms of protumor effects of autophagy, we developed a mouse model that allowed the acute and reversible inhibition of autophagy. We observed that autophagy inhibition causes significant tumor regression in an autochthonous mouse model of PDAC. A detailed analysis of these effects indicated that the tumor regression was likely multifactorial, involving both tumor cell-intrinsic and host effects. Thus, our study supports that autophagy inhibition in PDAC may have future utility in the treatment of pancreatic cancer and illustrates the importance of assessing complex biological processes in relevant autochthonous models.<b>Significance:</b> This work demonstrates that autophagy is critical pancreatic tumor maintenance through tumor cell-intrinsic and -extrinsic mechanisms. These results have direct clinical relevance to ongoing clinical trials as well as drug-development initiatives. <i>Cancer Discov; 8(3); 276-87. ©2018 AACR.</i><i>See related commentary by Noguera-Ortega and Amaravadi, p. 266</i><i>This article is highlighted in the In This Issue feature, p. 253</i>.
Some Deviations Associated With Vector Perturbation Diffraction Theory (1985)

Last year at this conference our lab presented some data which strongly supports the use of the vector perturbation relationship between light scattered from smooth surfaces and the surface power spectral density (PSD). Last year's data showed that a consistent answer was obtained for the PSD for measurements taken with S and P polarization, with incident angles up to 45', for positive and negative sweeps, and for one and two dimensional samples. If in fact the theoretical relationship is correct then this must be the case, as the PSD is determined by a combination of surface topography and the scattering situation (geometry, polarization, wavelength, etc.). It appears, however that for large scatter angles (>700) and for large angles of incidence (>60Ã‚Â°) there is some deviation in the calculated PSD. In addition, the high angle scatter region is an area where a scatterometer with a semicircular detector sweep loses the one-to-one relationship between detector position and surface spatial frequency. Or, in other words, light diffracted to high scatter angles from single spatial frequencies appears over a small band on the observation semicircle instead of a diffraction limited point. Fata supporting these two deviations is presented. Although they are not regarded as serious violations of the vector perturbation theory they do impose a limit on the useful range over which the PSD may be calculated.
Lithium Plating Detection and Quantification in Li-Ion Cells from Degradation Behaviors (2017)

Lithium plating has huge impact on the lifetime and safety of lithium-ion cells, thus sensitive and readily accessible methods to detect lithium plating is of high interest. This study conducted two sets of cycling tests of lithium-ion cells, one examined 7 stresses and 3 levels using design of experiment (DOE) L18(2×37), the other examined 3 stresses and 3 levels using DOE L27(313). Three lithium plating detection methods are proposed: resistance-capacity(R-Q) plot method, Arrhenius method and capacity fade rate method. The cells were disassembled, selectively titrated, and the amount of plated lithium was measured with inductively coupled plasma(ICP). ICP results corroborates the results of the R-Q plot methods and the three proposed methods are consistent with each other. The methods developed in this study only need the electric quantities which can be readily measured without dissembling the cell.
<title>Al-Ga-In-As-P alloy system in low-pressure MOVPE</title> (1992)

The growing request for advanced structures in the opto- and microelectronic field has led to the development of epitaxial growth techniques capable for atomic layer sharp transitions in crystal composition. A very important role under these techniques is played by the MOVPE. The deposition of semiconductor materials from metal-organyl complex compounds of group III elements and hydride compounds of group V elements has been refined by means of developments in reactor technology and improvement of the source materials. An exceptional improvement was reached by introducing reduced pressure operation of the described process. The present work is an overview of the process performance and optimization in Low Pressure MOVPE for a selection of compound semiconductors from the Al-Ga-In-As-P alloy system lattice matched to either InP or GaAs. Conventional sources are used to grow the materials from the described alloy system. The influence of various process parameters on important material properties are discussed.
A two-photon activatable amino acid linker for the induction of fluorescence (2015)

A new one- and two-photon activatable fluorophore based on ATTO565 was developed using a photolabile linker that simultaneously acts as a quencher. It is especially interesting for protein and peptide applications because it can be incorporated by standard peptide chemistry. The application of the new fluorogenic construct in super-resolution microscopy of antibody conjugates is shown.
The effect of long-term grazing treatments on the establishment of woody plants in southern African Savanna (1997)

Eight paddocks which were debushed to an open savanna during 1935/36 and subsequently grazed annually during different seasons by steers were surveyed after a period of 54 years. Though woody plants have increased in all the paddocks, regardless of the grazing treatment, the rate of woody plant establishment was notably higher in those paddocks that received a more intense annual grazing treatment. This effect was most noticeable in those paddocks of which the mean Animal Unit-grazing days ha-1 exceeded 100 days annually. These results confirm the existence of a positive linear relationship between the severity of the grazing treatment and the rate at which woody plants have increased.
Dynamics of cell wall structure in<i>Saccharomyces cerevisiae</i> (2002)

The cell wall of Saccharomyces cerevisiae is an elastic structure that provides osmotic and physical protection and determines the shape of the cell. The inner layer of the wall is largely responsible for the mechanical strength of the wall and also provides the attachment sites for the proteins that form the outer layer of the wall. Here we find among others the sexual agglutinins and the flocculins. The outer protein layer also limits the permeability of the cell wall, thus shielding the plasma membrane from attack by foreign enzymes and membrane-perturbing compounds. The main features of the molecular organization of the yeast cell wall are now known. Importantly, the molecular composition and organization of the cell wall may vary considerably. For example, the incorporation of many cell wall proteins is temporally and spatially controlled and depends strongly on environmental conditions. Similarly, the formation of specific cell wall protein-polysaccharide complexes is strongly affected by external conditions. This points to a tight regulation of cell wall construction. Indeed, all five mitogen-activated protein kinase pathways in bakers' yeast affect the cell wall, and additional cell wall-related signaling routes have been identified. Finally, some potential targets for new antifungal compounds related to cell wall construction are discussed.
Successful fertilization by testicular spermatozoa in an in-vitro fertilization programme (1993)

Journal Article Successful fertilization by testicular spermatozoa in an in-vitro fertilization programme Get access R. Schoysman, R. Schoysman Fertility Unit Van Helmont Hospital VilvoordeBelgium Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Vanderzwalmen, P. Vanderzwalmen Fertility Unit Van Helmont Hospital VilvoordeBelgium Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Nijs, M. Nijs Fertility Unit Van Helmont Hospital VilvoordeBelgium Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Segal-Bertin, G. Segal-Bertin Fertility Unit Van Helmont Hospital VilvoordeBelgium Search for other works by this author on: Oxford Academic PubMed Google Scholar M. van de Casseye M. van de Casseye Fertility Unit Van Helmont Hospital VilvoordeBelgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 8, Issue 8, 1 August 1993, Pages 1339–1340, https://doi.org/10.1093/oxfordjournals.humrep.a138254 Published: 01 August 1993
Nf-κb-Dependent Inhibition of HIV-1 Transcription by Withaferin A (2017)

Despite the remarkable progress made in suppressing HIV-1 infection, antiretroviral drugs are still often inaccessible in developing countries, and there is an urgent need for cheaper and alternative drugs. HIV-1 replication is triggered by the activation of the long terminal repeat (LTR) promoter, which contains two binding sites for the transcription factor nuclear factor κB (NF-κB). Withaferin A (WA), a steroidal lactone isolated from the Indian medicinal plant Withania somnifera, has been found to have significant pharmacological effects on the regulation of immune response. Recent studies have demonstrated that the anti-inflammatory properties of WA are mainly due to its inhibition of the NF-κB pathway. In the present study, we demonstrate that WA represses HIV-1 LTR transcription and viral replication through NF-κB inhibition. The human lymphocyte T cell line Jurkat E6.1 was treated with WA and infected with wild-type pseudotyped HIV- 1 particles or mutant viruses containing inactive κB sites. Then, the effect of WA on HIV-1 replication was evaluated by the measurement of reporter activity. Electrophoretic mobility shift assays and Western blots analysis were also performed to study the impact of WA on NF-κB. We found that WA inhibited the transcription of wild-type pseudotyped viruses in single-round infection assays, whereas mutant viruses containing inactive κB sites showed a reduced response to WA. Moreover, we found that WA directly or indirectly inhibits NF-κB nuclear translocation, including RelA and p50 subunits. However, the degradation of inhibitory protein IκB-α was not prevented by WA. Taken together, our results suggest that WA inhibits HIV-1 transcription in human Jurkat E6.1 lymphocyte T cells through the NF-κB pathway.
Pneumatic micro finger as endeffecter of robot (2006)

This paper reports the pneumatic PDMS micro finger as an endeffector of robot. The micro finger structures consist of two PDMS films with different mixing ratio of the base polymer and curing agent. An applied air pressure mainly contributes to the generation of the pulling force of the top PDMS layer with excess Si-H group and the large deformation of the flexible bottom layer with excess vinyl group. This combination of the micro finger or hand with a rigid PDMS layer and a flexible one is based on the human being's finger or hand. For the proper structural design rule, in this paper, the micro finer structures with different balloon shape are fabricated and tested by a pneumatic force. While the thickness ratio of the bottom layer and the top one is about 3, the bending angle of micro finger is most sensitive to the applied air pressure. During the repeat test for about 5 hours, there are no any noticeable degradation on the bending motion and the structural failure. The hybrid motion of the micro finger with two or three degree of freedom in micro world and the guide robot in macro world is successfully realized by using VR (virtual realty) system
Adaptive filter for event-related bioelectric signals using an impulse correlated reference input: comparison with signal averaging techniques (1992)

Many bioelectric signals result from the electrical response of physiological systems to an impulse that can be internal (ECG signals) or external (evoked potentials). In this paper an adaptive impulse correlated filter (AICF) for event-related signals that are time-locked to a stimulus is presented. This filter estimates the deterministic component of the signal and removes the noise uncorrelated with the stimulus, even if this noise is colored, as in the case of evoked potentials. The filter needs two inputs: the signal (primary input) and an impulse correlated with the deterministic component (reference input). We use the LMS algorithm to adjust the weights in the adaptive process. First, we show that the AICF is equivalent to exponentially weighted averaging (EWA) when using the LMS algorithm. A quantitative analysis of the signal-to-noise ratio improvement, convergence, and misadjustment error is presented. A comparison of the AICF with ensemble averaging (EA) and moving window averaging (MWA) techniques is also presented. The adaptive filter is applied to real high-resolution ECG signals and time-varying somatosensory evoked potentials.
Overview of IEC 61850 and Benefits (2006)

Legacy substation automation protocols and architectures typically provided basic functionality for power system automation and were designed to accommodate the technical limitations of the networking technology available for implementation. There has recently been a vast improvement in networking technology that has changed dramatically what is now feasible for power system automation in the substation. Technologies such as switched Ethernet, TCP/IP, high-speed wide area networks, and high-performance low-cost computers are providing capabilities that could barely be imagined when most legacy substation automation protocols were designed. In order to take advantage of modern technology to deliver additional new benefits to users of substation automation, the International Electrotechnical Commission (IEC) has developed and released a new global standard for substation automation: IEC 61850. The paper provides a basic technical overview of IEC 61850 and discusses the benefits of each major aspect of the standard. The concept of a virtual model comprising both physical and logical device models that includes a set of standardized communications services are described along with explanations of how these standardized models, object naming conventions, and communication services bring significant benefits to the substation automation user. New services to support self-describing devices and object-orient peer-to-peer data exchange are explained with an emphasis on how these services can be applied to reduce costs for substation automation. The substation configuration language (SCL) of IEC 61850 is presented with information on how the standardization of substation configuration will impact the future of substation automation. The paper concludes with a brief introduction to the UCA International Users Group as a forum where users and suppliers cooperate in improving substation automation with testing, education, and demonstrations of IEC 61850 and other IEC standards technology
Covering a simple orthogonal polygon with a minimum number of orthogonally convex polygons (1987)

The problem of covering a polygon with convex polygons has proven to be very difficult, even when restricted to the class of orthogonal polygons using orthogonally convex covers. We develop a method of analysis based on dent diagrams for orthogonal polygons, and are able to show that Keil's Ο(n2) algorithm for covering horizontally convex polygons is optimal, but can be improved to Ο(n) for counting the number of polygons required for a minimal cover. We also give an optimal Ο(n2) algorithm for covering another subclass of orthogonal polygons. Finally, we develop a method of signatures which can be used to obtain polynomial time algorithms for an even larger class of orthogonal polygons.
An intelligent customer-controlled switching system (2003)

Proposes an intelligent customer-controlled private switching system using knowledge processing. Knowledge processing is used to enhance the user-support function, because it can treat the semantics of customer data. The authors present the basic system concepts and outline the experimental model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>