gebhart/patrepeval huggingface dataset:
Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis. (1988)

A strong correlation was found between the basal levels of membrane-bound protein kinase C and the ability of B16 melanoma cell sublines (F10, F1, and BL6) to metastasize to the lung after intravenous injection. By treating with tumor-promoting phorbol esters for 1 hr, the low-metastasizing F1 cells exhibited both translocation of protein kinase C from cytosol to plasma membrane and an increase in metastasis to a level comparable to the (untreated) highly metastatic subline F10. Prolonged treatment of melanoma sublines with phorbol 12-myristate 13-acetate for 24 hr resulted in both inactivation of protein kinase C activity and loss of their metastasizing capabilities. Under conditions that induced only the activation of protein kinase C but not its membrane association, no increase in metastasis occurred, suggesting that activation of protein kinase C alone is insufficient to promote metastasis and that its membrane association is also necessary. Exposure of B16 melanoma sublines to phorbol esters for 1 hr had (i) no effect on the growth and morphology of these cells in vivo and in vitro and (ii) a short-term effect (approximately equal to 5 hr) on membrane association of protein kinase C. Nonetheless, in this period, the membrane-bound protein kinase C, probably by influencing cell-surface and cell-attachment properties, increased the retention of circulating melanoma cells in the lung, which eventually led to an increased number of metastatic nodules. The membrane-bound protein kinase C activity also correlated with metastatic ability in rapidly growing cells, growth-arrested cells, and cells growing in a low-Ca2+ medium. The results strongly suggest that the membrane-bound protein kinase C influences hematogenous metastasis of tumor cells and show that tumor promoters like phorbol esters have an additional role in promoting hematogenous spread of cancer in the body.
Monolithic GaAs HBT p-i-n diode variable gain amplifiers, attenuators, and switches (1993)

The authors report on monolithic circuits integrating HBTs and p-i-n diode using a common HBT MBE structure. An HBT variable gain amplifier using p-i-n diode as a variable resistor achieved a gain of 14.6 dB, a bandwidth out to 9 GHz, a gain control range of >15 dB, and an IP3 of 28 dBm. A two-stage HBT p-i-n diode attenuator from 1-10 GHz and an X-band one-pole two-throw HBT p-i-n diode switch were also demonstrated. The two-stage p-i-n attenuator has over 50 dB dynamic range at 2 GHz and a maximum IP3 of 9 dBm. The minimum insertion loss is 1.7 dB per stage and has a flat response to 10 GHz. The X-band switch has an insertion loss of 0.82 dB and an off-isolation of 25 dB. The bandwidth is greater than 35% and the IP3 is greater than 34.5 dBm. These circuits consist of p-i-n diodes constructed from the base-collector MBE layers of a baseline HBT process. This is the first monolithic integration of p-i-n diode switch, variable gain control, and attenuation functions in an HBT technology without additional processing steps or MBE material growth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preparation and Properties of Organic-Inorganic Hybrid Materials Based on Poly{(butyl methacrylate)-co- [(3-methacryloxypropyl)trimethoxysilane]} (2001)

In this research, hybrid materials based on poly{(butyl methacrylate)-co-[(3-methacryloxypropyl)trimethoxysilane]} were synthesized via a sol-gel process. The physical properties of the materials with various silica contents were investigated. It was found from infrared spectra data that the organic-inorganic interface was bonded not only by covalent bonds but also by a portion of hydrogen bonds. A second glass transition temperature appeared when there was more than 60 mol-% silane in this hybrid system. The thermogravimetric data illustrated that all the hybrid materials decomposed in three stages, whereas the homopolymer of butyl methacrylate decomposed in only one stage. It is deduced that when the silane content is 60 mol-% or more, part of organic chain segments was found restricted by the inorganic phase.
Inhibitory Effects of Glibenclamide on Cystic Fibrosis Transmembrane Regulator, Swelling-Activated, and Ca <sup>2+</sup> -Activated Cl <sup>−</sup> Channels in Mammalian Cardiac Myocytes (1997)

Recent studies have provided evidence that sulfonylureas, in addition to blocking ATP-sensitive K+ (KATP) channels, also inhibit cystic fibrosis transmembrane regulator (CFTR) Cl- channels in epithelial and cardiac cells. The purpose of this study was to test whether the sulfonylurea glibenclamide might also inhibit other types of cardiac Cl- channels. Whole-cell patch-clamp techniques were used to compare the effects of glibenclamide on CFTR Cl- currents in guinea pig ventricular myocytes, swelling-activated Cl- currents in guinea pig atrial myocytes, and Ca(2+)-activated Cl- currents in canine ventricular myocytes. Glibenclamide markedly inhibited CFTR Cl- currents in a voltage-independent manner at 22 degrees C, with estimated IC50 values of 12.5 and 11.0 mumol/L at +50 and -100 mV, respectively. The outwardly rectifying swelling-activated Cl- current in atrial cells was less sensitive to glibenclamide, and the block exhibited voltage dependence. At 22 degrees C, the estimated IC50 values were 193 and 470 mumol/L at +50 and -100 mV, respectively, and block was enhanced at 35 degrees C. Macroscopic Cl- currents activated by a rise in intracellular Ca2+, induced by either Ca(2+)-induced Ca2+ release or by external application of the Ca2+ ionophore A23187, were also markedly inhibited at 22 degrees C by glibenclamide in a voltage-independent manner. The estimated IC50 values were 61.5 and 69.9 mumol/L at +50 and -100 mV, respectively. These results suggest that glibenclamide, an inhibitor of cardiac CFTR Cl- channels, also inhibits swelling-activated and Ca(2+)-activated Cl- channels at higher concentrations. The results also suggest that studies attributing the beneficial or deleterious effects of sulfonylurea compounds in the heart solely to blockade of KATP channels should use submicromolar concentrations of these agents to minimize possible secondary interactions with cardiac Cl- channels.
A Dual-Side Controlled Inductive Power Transfer System Optimized for Large Coupling Factor Variations and Partial Load (2015)

In this study, a 3-kW inductive power transfer system is investigated, specifically intended for contactless vehicle charging. A series-series-compensated topology with dual-side power control and a corresponding control strategy is proposed to significantly increase the overall efficiency, especially for systems with large coupling factor variations and in partial load mode. The topology, which is closely related to the dual-active bridge converter, enables the dual-side power control without adding additional dc/dc converters to the system, and thus keeping the additional hardware effort minimal. A detailed analysis of the proposed topology is provided, and the benefits of the dual-side control are demonstrated both theoretically and experimentally. A hardware prototype is built and a peak dc-to-dc efficiency of 95.8% at 100 mm air gap and a minimal efficiency of 92.1% at 170 mm air gap is measured, including the power electronic components. The partial load efficiency at 500 W output power is still as high as 90.6% at 135 mm air gap. Overall, the proposed topology provides a practical method to overcome the main drawback of most single-side controlled inductive power transfer systems, which is a significant efficiency drop outside the nominal operating point.
Highly Diastereoselective Ring-Opening Reactions of Chiral Acetals with Secondary or Sterically Hindered Grignard Reagents (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Diastereoselective Ring-Opening Reactions of Chiral Acetals with Secondary or Sterically Hindered Grignard ReagentsTien-Min Yuan, Sue-Min Yeh, Yu-Tsai Hsieh, and Tien-Yau LuhCite this: J. Org. Chem. 1994, 59, 26, 8192–8196Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jo00105a041https://doi.org/10.1021/jo00105a041research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
In-network, push-based network resource monitoring (2013)

We present preliminary work from our experiences with distributed, push-based monitoring of networks at Yahoo!. Network switches have grown beyond mere ASICs into machines which support unmodified Linux kernels and familiar user interfaces. These advances have enabled a paradigm shift in network monitoring. In lieu of traditional approaches where network diagnostics were delivered via SNMP we utilize Sysdb of Arista's EOS to implement a push based approach to network monitoring. This leaves the individual switches in charge of determining what monitoring data to send and when to send it. With this approach -- on-switch collection, dissemination, and analysis of interfaces and protocols become possible. This push based approach reduces the feedback loop of network diagnostics and enables networkaware applications, middleware and resource managers to have access to the freshest available data.
Summary of the Sandia Supercritical CO2 Development Program (Presentation). (2011)

Abstract not provided.
Cauchy Distribution for Jitter in IP Networks (2008)

In many real-time applications the Quality of Service (QoS ) is dominated by jitter. In this paper RTT (Round Trip Time) measurements were collected in order to find a probabilistic jitter model. From collected measurements the tail index was close to unit, this relates us to Cauchy's distribution. In this paper we show that the jitter has direct influence in the network performance. The purpose of this paper is to show how jitter dispersion affects the QoS in some applications.
Determination of Dithiocarbamates (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of DithiocarbamatesD Clarke, Harry Baum, E Stanley, and W HesterCite this: Anal. Chem. 1951, 23, 12, 1842–1846Publication Date (Print):December 1, 1951Publication History Published online1 May 2002Published inissue 1 December 1951https://pubs.acs.org/doi/10.1021/ac60060a034https://doi.org/10.1021/ac60060a034research-articleACS PublicationsCopyright © 2002 Request reuse permissionsArticle Views405Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanistic study of a synthetically useful monooxygenase model using the hypersensitive probe trans-2-phenyl-1-vinylcyclopropane (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanistic study of a synthetically useful monooxygenase model using the hypersensitive probe trans-2-phenyl-1-vinylcyclopropaneHong Fu, Gary C. Look, Wei Zhang, Eric N. Jacobsen, and Chi Huey WongCite this: J. Org. Chem. 1991, 56, 23, 6497–6500Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://doi.org/10.1021/jo00023a008Request reuse permissionsArticle Views997Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (435 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Observations on the use of GYPCHEK (1979)

This paper reports the results of the 1978 aerial test with the gypsy moth NPV product, GYPCHEK. Although a general population collapse was observed, conclusions could be made on the efficacy of three formulations and two aircraft nozzling systems. The molasses formulation was more effective when applied with Beecomist® nozzles, but Pro-tee® formulations were more effective when applied with Flat Fang® 8006 nozzles.
SRAM word-oriented redundancy methodology using built in self-repair (2004)

In this paper, a word-oriented built in self-repair (BISR) technique for SRAM bank is presented. All the repairs using BISR circuit are done during the reset period, and the process of referencing to the faulty line and its redundancy address are not required during the normal operation. The access time penalty is negligible and additional power consumption due to BISR circuit is kept minimum since it operates only during the reset time. Flexibility of this design technique allows to repair more numbers of faulty lines than conventional approaches with less area overhead.
Performance Modeling of Subnet Management on Fat Tree InfiniBand Networks using OpenSM (2005)

InfiniBand is becoming increasingly popular in the area of cluster computing due to its open standard and high performance. Fat tree is a primary interconnection topology for building large scale InfiniBand clusters. Instead of using a shared bus approach, InfiniBand employs an arbitrary switched point-to-point topology. In order to manage the subnet, InfiniBand specifies a basic management infrastructure responsible for discovery, configuration and maintaining the active state of the network. In the literature, simulation studies have been done on irregular topologies to characterize the subnet management mechanism. However, there is no study to model subnet management mechanism on regular topologies using actual implementations. In this paper, we take up the challenge of modeling subnet management mechanism for fat tree InfiniBand networks using a popular subnet manager OpenSM. We present the timings for various subnet management phases namely topology discovery, path computation and path distribution for large scale fat tree InfiniBand subnets and present basic performance evaluation on small scale InfiniBand cluster. We verify our model with the basic set of results obtained, and present the results for the model by varying different parameters on fat trees.
Biomaterials in cardiopulmonary bypass (1994)

The improved utilization of biomaterials in cardiopulmonary bypass is dependent on polymer science and technology, procedures for blood compatibility assessment, optimization of biomaterial/antithrombotic agent combinations and the interpretation of clinical data.
Inactivation of human plasma serine proteinase inhibitors (serpins) by limited proteolysis of the reactive site loop with snake venom and bacterial metalloproteinases (1986)

Abstract Human plasma serine proteinase inhibitors (serpins) gradually lost activity when incubated with catalytic amounts of snake venom or bacterial metalloproteinases. Electrophoretic analyses indicated that antithrombin III, C 1 ‐inhibitor, and α 2 ‐antiplasmin had been converted by limited proteolysis into modified species which retained inhibitory activity. Further proteolytic attack resulted in the formation of inactivated inhibitors; α 1 ‐proteinase inhibitor (α 1 ‐antitrypsin) and α 1 ‐antichymotrypsin were also enzymatically inactivated, but active intermediates were not detected. Sequence analyses indicated that the initial, noninactivating cleavage occurred in the amino‐terminal region of the inhibitors. Inactivation resulted in all cases from the limited proteolysis of a single bond near, but not at, the reactive site bond in the carboxy‐terminal region of the inhibitors. The results indicate that the serpins have two regions which are susceptible to limited proteolysis—one near the amino‐terminal end and another in the exposed reactive site loop of the inhibitor.
A small-signal equivalent-circuit model for GaAs-Al<i>x</i>Ga1−<i>x</i>As resonant tunneling heterostructures at microwave frequencies (1987)

This paper presents a study of the microwave impedance of GaAs-AlxGa1−xAs resonant tunneling heterostructures. An equivalent-circuit model is proposed that accounts for the frequency variation of the measured impedance and whose elements correspond to physical phenomena believed to be present in the device. Empirical formulas are obtained which can be used to calculate the values of the equivalent-circuit elements from the structural parameters and the dc current-voltage characteristics of the device.
Functional Characterization of <i>ttmM</i> Unveils New Tautomycin Analogs and Insight into Tautomycin Biosynthesis and Activity (2009)

The biosynthetic gene cluster for tautomycin (TTM), a potent protein phosphatase (PP) inhibitor has recently been characterized. Inactivation of ttmM, which encodes a putative C3' hydroxylase, afforded mutant SB6005 which accumulated three new 3'-deshydroxy TTM analogs, supporting the function of TtmM and the previously proposed linear pathway for TTM biosynthesis. Bioassays reveal the importance of the C3' OH moiety in PP inhibition and that PP inhibition is not the exclusive mechanism driving TTM-induced cell death.
2,3-Dihydroquinolin-4(1H)-ones. Part I. Halogen-substituted 2,3-dihydroquinolin-4(1H)-ones and their 1-(2-acylethyl) derivatives (1972)

Synthesis of five 6- or 8-halogen-substituted 2,3-dihydroquinolin-4(1H)-ones and their 1-acetyl derivatives are described. The 6-substituted compounds reacted with suitable Mannich bases to yield 1-(2-arenoylethyl) derivatives but 8-substituted compounds were unchanged under the same conditions. 1H N.m.r. and u.v. spectra of some of the compounds are recorded.
Plug-and-actuate on demand: multimodal individual addressability of microarray plates using modular hybrid acoustic wave technology (2017)

The microarray titre plate remains a fundamental workhorse in genomic, proteomic and cellomic analyses that underpin the drug discovery process. Nevertheless, liquid handling technologies for sample dispensing, processing and transfer have not progressed significantly beyond conventional robotic micropipetting techniques, which are not only at their fundamental sample size limit, but are also prone to mechanical failure and contamination. This is because alternative technologies to date suffer from a number of constraints, mainly their limitation to carry out only a single liquid operation such as dispensing or mixing at a given time, and their inability to address individual wells, particularly at high throughput. Here, we demonstrate the possibility for true sequential or simultaneous single- and multi-well addressability in a 96-well plate using a reconfigurable modular platform from which MHz-order hybrid surface and bulk acoustic waves can be coupled to drive a variety of microfluidic modes including mixing, sample preconcentration and droplet jetting/ejection in individual or multiple wells on demand, thus constituting a highly versatile yet simple setup capable of improving the functionality of existing laboratory protocols and processes.
New Cytotoxic Seco-Type Triterpene and Labdane-Type Diterpenes from Nuxia oppositifolia (2017)

Chromatographic purification of the <i>n</i>-hexane and dichloromethane extracts of <i>Nuxia oppositifolia</i> aerial parts, growing in Saudi Arabia, resulted in the isolation and characterization of three new labdane-type diterpene acids, 2β-acetoxy-labda-7-en-15-oic acid (<b>1</b>), 2β-acetoxy-7-oxolabda-8-en-15-oic acid (<b>2</b>), 2β-acetoxy-6-oxolabda-7-en-15-oic acid (<b>3</b>), and one new seco-triterpene, 3,4-seco olean-12-en-3,30 dioic acid (<b>4</b>), together with 10 known lupane, oleanane and ursane-type triterpenes, as well as the common phytosterols, β-sitosterol and stigmasterol (<b>5</b>-<b>16</b>). Their structures have been assigned on the basis of different spectroscopic techniques including 1D and 2D NMR. Moreover, 13 of the isolated compounds were tested on the human cancer cell lines HeLa (cervical), A549 (lung) and MDA (breast), and most of the compounds showed potent cytotoxic activities in vitro.
Feline Immunodeficiency Virus Infection of Macrophages: <i>In Vitro</i> and <i>in Vivo</i> Inhibition by Dideoxycytidine-5′-triphosphate-Loaded Erythrocytes (1994)

Although HIV-1 and other mammalian lentiviruses infect macrophages, they are not cytopathic. Consequently, these infected long-lived cells serve as major virus reservoirs with a key role in the propagation of the virus throughout the body as well as in the pathogenesis of AIDS. Furthermore, well-differentiated macrophages possess low abilities to phosphorylate the most common reverse transcriptase inhibitors of the nucleoside analog family. In an attempt to overcome these problems we have evaluated in vitro and in vivo in a feline immunodeficiency animal model whether it is possible to protect macrophages from FIV infection by direct administration of dideoxycytidine-5'-triphosphate (ddCTP). Because the cell membranes are impermeable to phosphorylated drugs we have encapsulated ddCTP into autologous erythrocytes. The drug-loaded erythrocyte membranes were then modified to target these carrier cells to macrophages. ddCTP-loaded erythrocytes were able to reduce FIV production by macrophages infected in vitro or obtained from naturally or experimentally infected cats. Furthermore, the administration of ddCTP-loaded erythrocytes protected the majority of peritoneal macrophages during a 7-month experimental FIV infection and reduced the percentage of circulating lymphocytes stained by an anti-p24 antibody. These results suggest that the administration of nucleoside analogs in phosphorylate form is feasible and their targeting to macrophages reduces FIV infection both in vitro and in vivo.