gebhart/patrepeval huggingface dataset:
Infections, Inflammation, and the Risk of Coronary Heart Disease (2000)

Background —The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk. Methods and Results —We measured baseline levels of C-reactive protein (CRP) and antibodies to adenovirus, enterovirus, cytomegalovirus, and herpes simplex virus as well as to Chlamydia pneumoniae ( Cpn ) and Helicobacter pylori in 241 subjects who suffered either myocardial infarction or coronary death during the 8.5-year trial in the Helsinki Heart Study, a coronary primary prevention trial. The 241 controls in this nested case-control study were subjects who completed the study without coronary events. Antibody levels to herpes simplex type I (HSV-1) and to Cpn were higher in cases than in controls, whereas the distributions of antibodies to other infectious agents were similar. Mean CRP was higher in cases (4.4 versus 2.0 mg/L; P <0.001), and high CRP increased the risks associated with smoking and with high antimicrobial antibody levels. The odds ratios in subjects with high antibody and high CRP levels were 25.4 (95% CI 2.9–220.3) for HSV-1 and 5.4 (95% CI 2.4–12.4) for Cpn compared with subjects with low antibody levels and low CRP. High antibody levels to either HSV-1 or to Cpn increased the risk independently of the other, and their joint effect was close to additive. Conclusions —Two chronic infections, HSV-1 and Cpn , increase the risk of coronary heart disease. The effect is emphasized in subjects with ongoing inflammation, denoted by increased CRP levels.
Interworking between GPRS AND ISP for Wireless Internet Service of Mobile ISP Subscriber (2006)

In this paper we illustrate how visited mobile ISP subscriber can access home ISP via GGSN (Gateway GPRS Support Node) on GPRS (General Packet Radio Service) network. We also introduce messages between GGSN and ISP for wireless internet access of visited ISP subscriber, and a specific DHCP relay which can provide dynamic IP to visited ISP subscriber, and signaling for IP management using RADIUS authentication and account server for wireless internet service. The contribution of this paper is to suggest interworking solution between ISP and GPRS network for seamless internet service.
Dose Response of Almonds on Coronary Heart Disease Risk Factors: Blood Lipids, Oxidized Low-Density Lipoproteins, Lipoprotein(a), Homocysteine, and Pulmonary Nitric Oxide (2002)

Almonds used as snacks in the diets of hyperlipidemic subjects significantly reduce coronary heart disease risk factors, probably in part because of the nonfat (protein and fiber) and monounsaturated fatty acid components of the nut.
A pattern of Augmented Video Services in Access Grid (2010)

The Access Grid (AG) is an important component of grid, and it can provide immersive, interactive and collaborative access to grid applications. The AG users usually enter the collaboration space with the need of collaboratively manipulating the 3D geometric model of grid services' result in the real video environment. Due to Augmented Reality (AR) characteristics of combining virtual and real, real-time interaction and 3D registration, it is necessary to utilize AR to investigate a new pattern of video services, merging the real video scene of AG and 3D geometric model of grid services' results to allow users' manipulating the model in the real video scene. This paper proposes a pattern of Augmented Video Services (AVS) in AG. The pattern firstly illuminates the augmented video formation method based on combining real and virtual, secondly gives the transmission modes of augmented video information to provide shared augmented video stream for every AG user, and thirdly manages the augmented video session of AG by means of Session Announcement Protocol (SAP) and Session Description Protocol (SDP). At the end of this paper, a series of experiments are given to demonstrate the validity and usability of this AVS pattern.
A secure biometric authentication scheme based on robust hashing (2005)

In this paper, we propose a secure biometric based authentication scheme which fundamentally relies on the use of a robust hash function. The robust hash function is a one-way transformation tailored specifically for each user based on their biometrics. The function is designed as a sum of properly weighted and shifted Gaussian functions to ensure the security and privacy of biometric data. We discuss various design issues such as scalability, collision-freeness and security. We also provide test results obtained by applying the proposed scheme to ORL face database by designating the biometrics as singular values of face images.
[Mn(bipyridyl)(CO)<sub>3</sub>Br]: An Abundant Metal Carbonyl Complex as Efficient Electrocatalyst for CO<sub>2</sub> Reduction (2011)

Manganese at work: carbonyl bipyridyl complexes based on manganese, a non-noble abundant and inexpensive metal, have been proved to be excellent molecular catalysts for the selective electrochemical reduction of CO(2) to CO under mild conditions. Another advantage of manganese complexes over rhenium complexes is that these catalysts operate at markedly less overpotential (0.40 V gain).
On Using Demographic Variables to Determine Segment Membership in Logit Mixture Models (1994)

The authors propose an extension of the logit-mixture model that defines prior segment membership probabilities as functions of concomitant (demographic) variables. Using this approach it is possible to describe how membership in each of the segments, segments being characterized by a specific profile of brand preferences and marketing variable sensitivities, is related to household demographic characteristics. An empirical application of the methodology is provided using A.C. Nielsen scanner panel data on catsup. The authors provide a comparison with the results obtained using the extant methodology in estimation and validation samples of households.
Effects of Quaternary-Ammonium-Based Formulations on Bacterial Community Dynamics and Antimicrobial Susceptibility (2004)

Quaternary ammonium compounds (QACs) are widely used as adjuncts to hygiene in domestic cleaning products. Current concern that the increased use of such biocides in consumer products might contribute to the emergence of antibiotic resistance has led us to examine the effects of a QAC-containing domestic cleaning fluid on the population dynamics and antimicrobial susceptibility of domestic sink drain biofilm communities. QAC susceptibilities of numerically dominant, culturable drain bacteria (15 genera, 17 species) were determined in vitro before and after repeated QAC exposure (14 passages). A fully characterized drain microcosm was then exposed to short-term (12 days) and long-term (3 months) dosing with a QAC-containing domestic detergent (QD). QAC exposure of isolated cultures caused both increases (three species) and circa twofold decreases (six species) in QAC susceptibility. The susceptibility of Ralstonia sp. was considerably decreased following 14 consecutive QAC passages. Control drain microcosm biofilms maintained dynamic stability, as evidenced by culture and denaturing gradient gel electrophoresis (DGGE) analysis. Bacterial population densities were largely unaffected during short-term exposure to use levels of QD, although 50% QD caused circa 10-fold viability reductions. DGGE analysis supported these observations; identified the major microcosm genera as Pseudomonas, Pseudoalteromonas, Erwinia, and Enterobacter, and showed that aeromonads increased in abundance under 10 to 50% QD. Long-term exposure of the microcosms to QD did not significantly alter the pattern of antimicrobial susceptibility. These data demonstrate the recalcitrance of domestic drain biofilms toward QAC and that although repeated QAC exposure of drain isolates in pure culture results in susceptibility change in some test bacteria, such changes do not necessarily occur within complex communities.
Human Tissue Factor Pathway Inhibitor Fused to CD4 Binds both FXa and TF/FVIIa at the Cell Surface (1997)

Tissue factor pathway inhibitor (TFPI) is one of the main regulators of the tissue factor (TF) pathway of coagulation. To tether human TFPI to the cell surface, full length or truncated TFPI lacking the third Kunitz domain were fused with domains three and four and the carboxy-terminal sequence of human CD4. Constructs were transfected into a mouse fibroblast cell line and individual clones were checked for expression using monoclonal antibodies directed against the first two TFPI Kunitz domains and against CD4. Specific human FXa binding was detected by flow cytometry using an anti-FX polyclonal antibody, and inhibition of FXa proteolytic activity was verified by chromogenic substrate assay using S-2765. In addition, TFPI-CD4-expressing cells, preincubated with FXa, specifically bound human TF-FVIIa complexes as revealed with an anti-human TF polyclonal antibody. No functional difference was observed between full length or truncated TFPI-CD4. These results demonstrate that functionally intact TFPI can be tethered to the cell surface. Genetic manipulation of, for example, endothelial cells leading to the stable expression of TFPI may inhibit the development of coronary artery heart disease following cardiac allotransplantation, and may inhibit thrombosis in the context of xenotransplantation.
An alternative method for repair of a leaking arterial chemotherapy infusion catheter (1987)

Regional chemotherapy infusion via selective arterial catheterization is frequently complicated by the development of cracks or leaks within the catheter. This frequently necessitates a catheter exchange. Herein, we report an alternative, simpler method for dealing with a defect within an infusion catheter.
Low-Temperature H<sub>2</sub>S Removal from Steam-Containing Gas Mixtures with ZnO for Fuel Cell Application. 1. ZnO Particles and Extrudates (2004)

Sulfur removal is important for a fuel cell that uses a hydrocarbon fuel, such as natural gas, liquefied petroleum gas, and gasoline, to prevent the downstream sulfur poisoning of catalysts in the fuel processor and in the fuel cell anode. Although most sulfur species are removed prior to reforming, the reducing environment of the reforming stage (such as autothermal reforming) converts residual sulfur to hydrogen sulfide (H2S). H2S in the reformate must be removed to ensure longevity of the catalysts in downstream processing and in the anode chamber of fuel cell systems. A unique modified ZnO sample with a different morphology has been prepared and comparatively studied together with a commercially available ZnO sample under various conditions. Extremely low H2S outlet concentrationsas low as 20 parts per billion by volume (ppbv)have been observed over the modified ZnO sample for extended periods of times. The sulfur-trap capacity (the amount of H2S trapped before breakthrough) also is dependent on space velocity, temperature, steam concentration, CO2 concentration, and particle size. Higher capacity is observed at higher H2S inlet concentration of 8 ppmv, compared to lower inlet concentrations of 1−4 ppmv. The trap capacity decreases monotonically as the temperature increases. Steam in the reformate inhibits the capture of H2S by ZnO; it seems to shift the equilibrium of the reaction ZnO(s) + H2S(g) ⇔ ZnS(s) + H2O(g) to the left, toward ZnO and H2S. The effect of steam seems to be reversible. Increasing the CO2 concentration in the feed up to 12 vol % decreases the capacity of ZnO for the capture of H2S.
Retinal Biosynthesis in Fungi: Characterization of the Carotenoid Oxygenase CarX from<i>Fusarium fujikuroi</i> (2007)

The car gene cluster of the ascomycete Fusarium fujikuroi encodes two enzymes responsible for torulene biosynthesis (CarRA and CarB), an opsin-like protein (CarO), and a putative carotenoid cleaving enzyme (CarX). It was presumed that CarX catalyzes the formation of the major carotenoid in F. fujikuroi, neurosporaxanthin, a cleavage product of torulene. However, targeted deletion of carX did not impede neurosporaxanthin biosynthesis. On the contrary, DeltacarX mutants showed a significant increase in the total carotenoid content, indicating an involvement of CarX in the regulation of the pathway. In this work, we investigated the enzymatic activity of CarX. The expression of the enzyme in beta-carotene-accumulating Escherichia coli cells led to the formation of the opsin chromophore retinal. The identity of the product was proven by high-performance liquid chromatography and gas chromatography-mass spectrometry. Subsequent in vitro assays with heterologously expressed and purified CarX confirmed its beta-carotene-cleaving activity and revealed its capability to produce retinal also from other substrates, such as gamma-carotene, torulene, and beta-apo-8'-carotenal. Our data indicate that the occurrence of at least one beta-ionone ring in the substrate is required for the cleavage reaction and that the cleavage site is determined by the distance to the beta-ionone ring. CarX represents the first retinal-synthesizing enzyme reported in the fungal kingdom so far. It seems likely that the formed retinal is involved in the regulation of the carotenoid biosynthetic pathway via a negative feedback mechanism.
Evaluation of indium 111 labeled b 797 monoclonal antibodies as an agent for radiolabeling of human platelets (1985)

Development of agents specific for radiolabeling one type of blood cell is desirable. Preliminary evaluation of monoclonal antibodies (MAb) B79.7 specific for human platelet membrane glycoprotein III.a was carried out using In-111 as a tracer. MAb were labeled with In-111 using DTPA anhydride bi-functional chelate prepared by the modified method of a previous study. Excess of DTPA (800:1) was eliminated by a 0.3 cm x 20 cm. G-50 Sephadex column chromatography. MAb eluted were quantified spectrophotometrically. Indium-111 labeling (yield 70-80%) was accomplished in 0.25 M Citrate buffer pH-5. Platelets (l.5 billion) incubated (22/sup 0/C) with 25 nM In-111 MAb in plasma allowed up to 65% labeling efficiency. Incubation with 195 nM MAb inhibited platelet aggregation by approximately 50% of control platelets. When platelets were incubated with increasing number of In-111 MaB, saturable binding was observed. Scatchard analysis of these data revealed high MAb affinity (Kd 83-133 nM) and 16,000-22,000 receptor sites per platelet. In order to displace 50% platelet bound In-111 MaB molecules, 40 nM unlabeled MAb or 140 n M DTPA labeled MAb were required. The authors conclude that In-111 B79.7 Mab are promising agent for labeling human platelets and worthy of further investigation.
Testing and evaluating computer intrusion detection systems (1999)

article Free AccessTesting and evaluating computer intrusion detection systems Authors: Robert Durst SenCom Corp. SenCom Corp.View Profile , Terrence Champion US Air Force US Air ForceView Profile , Brian Witten US Air Force US Air ForceView Profile , Eric Miller US Air Force US Air ForceView Profile , Luigi Spagnuolo US Air Force US Air ForceView Profile Authors Info & Claims Communications of the ACMVolume 42Issue 7July 1999 pp 53–61https://doi.org/10.1145/306549.306571Published:01 July 1999Publication History 112citation3,395DownloadsMetricsTotal Citations112Total Downloads3,395Last 12 Months117Last 6 weeks29 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
The presumed-either two-phase commit protocol (2002)

This paper describes the presumed-either two-phase commit protocol. Presumed-either exploits log piggybacking to reduce the cost of committing transactions. If timely piggybacking occurs, presumed-either combines the performance advantages of presumed-abort and presumed-commit. Otherwise, presumed-either behaves much like the widely-used presumed-abort protocol.
The <i>trans</i> -Sialidase from <i>Trypanosoma cruzi</i> Induces Thrombocytopenia during Acute Chagas' Disease by Reducing the Platelet Sialic Acid Contents (2004)

Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease. The parasite sheds trans-sialidase, an enzyme able to mobilize the sialyl residues on cell surfaces, which is distributed in blood and is a virulence factor. Since the sialic acid content on the platelet surface is crucial for determining the half-life of platelets in blood, we examined the possible involvement of the parasite-derived enzyme in thrombocytopenia induction. We found that a single intravenous injection of trans-sialidase into naive mice reduced the platelet count by 50%, a transient effect that lasted as long as the enzyme remained in the blood. CD43(-/-) mice were affected to a similar extent. When green fluorescent protein-expressing platelets were treated in vitro with trans-sialidase, their sialic acid content was reduced together with their life span, as determined after transfusion into naive animals. No apparent deleterious effect on the bone marrow was observed. A central role for Kupffer cells in the clearance of trans-sialidase-altered platelets was revealed after phagocyte depletion by administration of clodronate-containing liposomes and splenectomy. Consistent with this, parasite strains known to exhibit more trans-sialidase activity induced heavier thrombocytopenia. Finally, the passive transfer of a trans-sialidase-neutralizing monoclonal antibody to infected animals prevented the clearance of transfused platelets. Results reported here strongly support the hypothesis that the trans-sialidase is the virulence factor that, after depleting the sialic acid content of platelets, induces the accelerated clearance of the platelets that leads to the thrombocytopenia observed during acute Chagas' disease.
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers (2017)

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance mediated by T790M-independent mechanisms remains a major challenge in the treatment of non-small cell lung cancer (NSCLC). We identified a targetable mechanism of EGFR inhibitor resistance whereby stress hormones activate β<sub>2</sub>-adrenergic receptors (β<sub>2</sub>-ARs) on NSCLC cells, which cooperatively signal with mutant EGFR, resulting in the inactivation of the tumor suppressor, liver kinase B1 (LKB1), and subsequently induce interleukin-6 (IL-6) expression. We show that stress and β<sub>2</sub>-AR activation promote tumor growth and EGFR inhibitor resistance, which can be abrogated with β-blockers or IL-6 inhibition. IL-6 was associated with a worse outcome in EGFR TKI-treated NSCLC patients, and β-blocker use was associated with lower IL-6 concentrations and improved benefit from EGFR inhibitors. These findings provide evidence that chronic stress hormones promote EGFR TKI resistance via β<sub>2</sub>-AR signaling by an LKB1/CREB (cyclic adenosine 3',5'-monophosphate response element-binding protein)/IL-6-dependent mechanism and suggest that combinations of β-blockers with EGFR TKIs merit further investigation as a strategy to abrogate resistance.
Determination of molecular weight of vacuum residue and their SARA fractions (2010)

The molecular weight of a number of vacuum residue and their SARA fractions (Saturated, Aromatics, Resins, and Asphaltenes) typical of the Barrancabermeja refinery in Colombia were determined using the following methods: Gel Permeation Chromatography (GPC), Vapor Pressure Osmometry, (VPO), and Simulated Distillation at High Temperature adjusted to the Gamma distribution function. Molecular weight results in vacuum residue and saturated and aromatics fraction obtained from the three techniques used show consistency within an acceptable range. However, the molecular weight results in resins and asphaltenes fraction obtained by the VPO technique significant differences compared with the results found using the techniques of GPC and DS-Gamma.
Pagoda: A Hybrid Approach to Enable Efficient Real-Time Provenance Based Intrusion Detection in Big Data Environments (2018)

Efficient intrusion detection and analysis of the security landscape in big data environments present challenge for today's users. Intrusion behavior can be described by provenance graphs that record the dependency relationships between intrusion processes and the infected files. Existing intrusion detection methods typically analyze and identify the anomaly either in a single provenance path or the whole provenance graph, neither of which can achieve the benefit on both detection accuracy and detection time. We propose Pagoda, a hybrid approach that takes into account the anomaly degree of both a single provenance path and the whole provenance graph. It can identify intrusion quickly if a serious compromise has been found on one path, and can further improve the detection rate by considering the behavior representation in the whole provenance graph. Pagoda uses a persistent memory database to store provenance and aggregates multiple similar items into one provenance record to maximumly reduce unnecessary I/O during the detection analysis. In addition, it encodes duplicate items in the rule database and filters noise that does not contain intrusion information. The experimental results on a wide variety of real-world applications demonstrate its performance and efficiency.
Using HTTP link (2010)

Gateway caches are intermediary components for reducing demands on destination servers, and therefore operational costs of a system. At scale, particularly with the advent of on-demand infrastructures such as EC2, etc., maximising cache efficiency translates into cost efficiency, resulting in a competitive advantage. In this position paper, we initially discuss advantages and limitations of HTTP caching mechanisms. We then propose to use HTTP Link: headers to maximise the efficiency of gateway (or reverse proxy) caching mechanisms and discuss early findings.
Diminished Monocyte Function in Microfilaremic Patients with Lymphatic Filariasis and Its Relationship to Altered Lymphoproliferative Responses (2005)

Antigen-specific hyporesponsiveness to filarial antigens is a phenomenon observed in patent infection with lymph-dwelling filarial parasites of humans. This phenomenon has been attributed to a multitude of factors, one of which is altered monocyte function. To examine the role played by monocytes in filarial infection, we assessed the responses of monocytes obtained from normal and filarial parasite-infected individuals to both crude filarial antigen and purified recombinant filarial antigen WbSXP-1 and attempted to relate these to the altered lymphoproliferative responses seen in filarial infection. Monocytes from microfilaremic (MF) patients demonstrated an inability to respond to lipopolysaccharide compared to monocytes from endemic normal persons or from lymphedema patients. Indeed, interleukin 1beta (IL-1beta) production was severely limited, a finding that did not extend to monocyte responses to filarial antigens. Serum from MF patients reduced adherence and spreading of normal monocytes, a finding not seen with serum from the other clinical groups. Interestingly, there was a significant correlation between the production of IL-1beta and adherence. Moreover, the levels of spontaneous production of IL-1beta correlated with high levels of spontaneous secretion of IL-10. The effects observed were not a result of diminished viability or alteration in the expression of the cell surface markers CD14 and HLA-DR. These data suggest that monocyte function is dampened in MF patients, a finding which could alter lymphoproliferative responses during patent infection.