gebhart/patrepeval huggingface dataset:
Cooperation between Cyclin E and p27Kip1 in Pituitary Tumorigenesis (2010)

Cushing's disease is caused by glucocorticoid-resistant pituitary corticotroph adenomas. We have previously identified the loss of nuclear Brg1 as one mechanism that may lead to partial glucocorticoid resistance: this loss is observed in about 33% of human corticotroph adenomas. We now show that Brg1 loss of function correlates with cyclin E expression in corticotroph adenomas and with loss of the cell cycle inhibitor p27(Kip1) expression. Because Brg1 is thought to have tumor suppressor activity, the present study was undertaken to understand the putative contribution of cyclin E derepression produced by loss of Brg1 expression on adenoma development. Overexpression of cyclin E in pituitary proopiomelanocortin cells leads to abnormal reentry into cell cycle of differentiated proopiomelanocortin cells and to centrosome instability. These alterations are consistent with the intermediate lobe hyperplasia and anterior lobe adenomas that were observed in these pituitaries. When combined with the p27(Kip1) knockout, overexpression of cyclin E increased the incidence of pituitary tumors, their size, and their proliferation index. These results suggest that cyclin E up-regulation and p27(Kip1) loss-of-function act cooperatively on pituitary adenoma development.
Low-power fully integrated and tunable CMOS RF wireless receiver for ISM band consumer applications (2005)

A 0.25-/spl mu/m single-chip CMOS single-conversion tunable low intermediate frequency (IF) receiver operated in the 902-928-MHz industrial, scientific, and medical band is proposed. A new 10.7-MHz IF section that contains a limiting amplifier and a frequency modulated/frequency-shift-key demodulator is designed. The frequency to voltage conversion gain of the demodulator is 15 mV/kHz and the dynamic range of the limiting amplifier is around 80 dB. The sensitivity of the IF section including the demodulator and limiting amplifier is -72 dBm. With on-chip tunable components in the low-power low-noise amplifier (LNA) and LC-tank voltage-controlled oscillator circuit, the receiver measures an RF gain of 15 dB at 915 MHz, a sensitivity of -80 dBm at 0.1% bit-error rate, an input referred third-order intercept point of -9 dBm, and a noise figure of 5 dB with a current consumption of 33 mA and a 2450 /spl mu/m/spl times/ 2450 /spl mu/m chip area.
Privacy-Preserving Statistical Analysis of Health Data Using Paillier Homomorphic Encryption and Permissioned Blockchain (2019)

Statistical analysis of health data is an essential task in healthcare. However, existing healthcare systems are incompatible with this critical need due to privacy restrictions. A recently emerged technology called Blockchain has shown great promise for mitigating this incompatibility. In this work, we aim to improve existing secure statistical analysis protocols by leveraging the blockchain technology. We propose a novel method that enables researchers to perform statistical analysis on health data in a privacy-preserving, secure, and precise manner.
Acidogenicity of high-intensity sweeteners and polyols. (1995)

The the high-intensity sweeteners (aspartame, saccharin and acesulfame-K) and the polyols (sorbitol and xylitol) were all non-acidogenic and were not significantly different from each other while both sucrose and fructose were highly acidogenic.
Antioxidant activity of probucol. Short communication. (1989)

To evaluate a possible antioxidant activity of probucol on NADPH-dependent microsomal lipid peroxidation and on iron-doxorubicin (adriamycin) complex-induced phospholipid peroxidation, the effects were compared with another powerful antioxidant, 2-OH-estrone. Antioxidant activity of 10 mumol/l probucol in NADPH-dependent microsomal lipid peroxidation corresponded to 4 mumol/l 2-OH-estrone. Together with the results obtained from iron-doxorubicin complex-induced phospholipid peroxidation, it was concluded that probucol is a potent inhibitor of lipid peroxidation and has one-quarter to one-half the antioxidant activity of 2-OH-estrone in vitro.
Detecting Potentially Virulent Vibrio vulnificus Strains in Raw Oysters by Quantitative Loop-Mediated Isothermal Amplification (2011)

Vibrio vulnificus is a leading cause of seafood-related deaths in the United States. Sequence variations in the virulence-correlated gene (vcg) have been used to distinguish between clinical and environmental V. vulnificus strains, with a strong association between clinical ones and the C sequence variant (vcgC). In this study, vcgC was selected as the target to design a loop-mediated isothermal amplification (LAMP) assay for the rapid, sensitive, specific, and quantitative detection of potentially virulent V. vulnificus strains in raw oysters. No false-positive or false-negative results were generated among the 125 bacterial strains used to evaluate assay specificity. The detection limit was 5.4 CFU per reaction for a virulent V. vulnificus strain (ATCC 33815) in pure culture, 100-fold more sensitive than that of PCR. In spiked raw oysters, the assay was capable of detecting 2.5 × 10(3) CFU/g of V. vulnificus ATCC 33815, while showing negative results for a nonvirulent V. vulnificus strain (515-4c2) spiked at 10(7) CFU/g. After 6 h of enrichment, the LAMP assay could detect 1 CFU/g of the virulent V. vulnificus strain ATCC 33815. Standard curves generated in pure culture and spiked oysters suggested a good linear relationship between cell numbers of the virulent V. vulnificus strain and turbidity signals. In conclusion, the LAMP assay developed in this study could quantitatively detect potentially virulent V. vulnificus in raw oysters with high speed, specificity, and sensitivity, which may facilitate better control of V. vulnificus risks associated with raw oyster consumption.
Optimised electroporation mediated DNA vaccination for treatment of prostate cancer (2010)

This phPSA plasmid electroporation vaccination strategy can effectively activate tumour specific immune responses. Optimisation of the approach indicated that a four-dose regimen provided highest tumour protection. In vivo electroporation mediated vaccination is a safe and effective modality for the treatment of prostate cancer and has a potential to be used as a neo-adjuvant or adjuvant therapy.
<i>Propionibacterium acnes</i>Postoperative Shoulder Arthritis: An Emerging Clinical Entity (2008)

The purpose of this study, which involved 276 patients, was to report the importance of Propionibacterium acnes in shoulder infections. The proportion of patients with shoulder infection who had infection due to P. acnes was significantly greater than the proportion of patients with lower limb infection who had infection due to P. acnes (9 of 16 patients vs. 1 of 233 patients; P < .001). This bacterium requires a prolonged incubation period and should not be considered to be a contaminant.
Hypersonic wave drag reduction performance of cylinders with repetitive laser energy depositions (2011)

It has been widely research that wave drag reduction on hypersonic vehicle by laser energy depositions. Using laser energy to reduce wave drag can improve vehicle performance. A second order accurate scheme based on finite-difference method and domain decomposition of structural grid is used to compute the drag performance of cylinders in a hypersonic flow of Mach number 2 at altitude of 15km with repetitive energy depositions. The effects of frequency on drag reduction are studied. The calculated results show: the recirculation zone is generated due to the interaction between bow shock over the cylinder and blast wave produced by energy deposition, and a virtual spike which is supported by an axis-symmetric recirculation, is formed in front of the cylinder. By increasing the repetitive frequency, the drag is reduced and the oscillation of the drag is decreased; however, the energy efficiency decreases by increasing the frequency.
ChemInform Abstract: ON THE ELECTROPHILIC SUBSTITUTION AND METALATION OF SELENOLOSELENOPHENES (1983)

Abstract Die Formylierung der Titelverbindungen (I) und (II) nach Vilsmeier wurde bereits beschrieben.
Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes. (1989)

Growth and differentiation of stem cells is thought to be regulated by growth factors and responding protein tyrosine kinase activities. Comparing mitotic stem cells from the adult intestinal epithelium, isolated from the crypts of Lieberkuhn, with isolated differentiated absorbtive cells we find major differences in the levels of phosphotyrosine-containing proteins. Crypt stem cells possess two major phosphotyrosine-containing polypeptides of 36 and 17 kD which have greater than 15 times more phosphotyrosine than that present in the polypeptides of differentiated enterocytes. Tyrosine kinase activity and similar phosphotyrosine-containing proteins are associated with the Triton cytoskeleton. Moreover, crypt tyrosine kinase(s) is active in vitro in phosphorylating similar cytoskeleton-associated substrates. These results suggest that cytoskeleton-associated phosphotyrosine kinase(s) and their substrates may play a role in growth and differentiation of adult intestinal epithelial cells.
Rapid sampling and analysis of extracellular dopamine in vivo (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid sampling and analysis of extracellular dopamine in vivoWilliam H. Church and Joseph B. JusticeCite this: Anal. Chem. 1987, 59, 5, 712–716Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ac00132a007https://doi.org/10.1021/ac00132a007research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prostate specific antigen-alpha 2-macroglobulin complexes in prostate cancer patient sera. (1995)

Quantitative immunoblotting of prostate cancer patient sera revealed that most prostate specific antigen was in complexes with alpha 1-antichymotrypsin or alpha 2-macroglobulin with little of it being free antigen. Complexes of prostate specific antigen with these protease inhibitors in patient sera comigrated during electrophoresis with the respective purified complexes. Each complex was selectively removed from patient sera by absorption with specific antibodies. When prostate specific antigen was added to normal plasma, complexes with alpha 2-macroglobulin appeared first and after 1 hr, the distribution was approximately 40% free antigen, approximately 40% complexes with alpha 2-macroglobulin, and approximately 20% complexes with alpha 1-antichymotrypsin. These data show that prostate specific antigen reacts more readily with alpha 2-macroglobulin than with any other protease inhibitor in plasma and that the antigen complexes with alpha 2-macroglobulin in vivo in cancer patients.
Predicting superhard materials via a machine learning informed evolutionary structure search (2019)

Abstract The computational prediction of superhard materials would enable the in silico design of compounds that could be used in a wide variety of technological applications. Herein, good agreement was found between experimental Vickers hardnesses, H v , of a wide range of materials and those calculated by three macroscopic hardness models that employ the shear and/or bulk moduli obtained from: (i) first principles via AFLOW-AEL (AFLOW Automatic Elastic Library), and (ii) a machine learning (ML) model trained on materials within the AFLOW repository. Because $$H_{\mathrm{v}}^{{\mathrm{ML}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mrow> <mml:mi>H</mml:mi> </mml:mrow> <mml:mrow> <mml:mi>v</mml:mi> </mml:mrow> <mml:mrow> <mml:mi>ML</mml:mi> </mml:mrow> </mml:msubsup> </mml:math> values can be quickly estimated, they can be used in conjunction with an evolutionary search to predict stable, superhard materials. This methodology is implemented in the X tal O pt evolutionary algorithm. Each crystal is minimized to the nearest local minimum, and its Vickers hardness is computed via a linear relationship with the shear modulus discovered by Teter. Both the energy/enthalpy and $$H_{{\mathrm{v,Teter}}}^{{\mathrm{ML}}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup> <mml:mrow> <mml:mi>H</mml:mi> </mml:mrow> <mml:mrow> <mml:mi>v,Teter</mml:mi> </mml:mrow> <mml:mrow> <mml:mi>ML</mml:mi> </mml:mrow> </mml:msubsup> </mml:math> are employed to determine a structure’s fitness. This implementation is applied towards the carbon system, and 43 new superhard phases are found. A topological analysis reveals that phases estimated to be slightly harder than diamond contain a substantial fraction of diamond and/or lonsdaleite.
Polypeptides. III. The Synthesis of High Molecular Weight Poly-γ-benzyl-L-glutamates<sup>1</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolypeptides. III. The Synthesis of High Molecular Weight Poly-γ-benzyl-L-glutamates1E. R. Blout and R. H. KarlsonCite this: J. Am. Chem. Soc. 1956, 78, 5, 941–946Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://pubs.acs.org/doi/10.1021/ja01586a020https://doi.org/10.1021/ja01586a020research-articleACS PublicationsRequest reuse permissionsArticle Views1603Altmetric-Citations342LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Regulation of human tissue factor expression by mRNA turnover. (1993)

Tissue factor serves as the cellular receptor for circulating blood coagulation factor VII and is the principal physiological initiator of blood coagulation. Tissue factor is not normally expressed in cells that contact blood, such as endothelial cells and monocytes, but can be induced in these cells by tumor necrosis factor or tumor-promoting phorbol esters. Following induction, the human tissue factor mRNA is degraded with a half-life of approximately 0.75-1.5 h. The cellular mechanisms responsible for this rapid mRNA turnover were investigated with chimeric tissue factor.beta-globin constructs expressed in stably transfected mouse NIH/3T3 cells. These constructs were expressed with the transiently inducible c-fos promoter which eliminated the need to use transcriptional inhibitors to determine mRNA half-lives. Sequences capable of conferring rapid turnover to the normally stable beta-globin transcript were localized to the last 600 nucleotides of the tissue factor mRNA. The 3' end of this fragment is similar to previously described AU-rich mRNA destabilizing elements. Activity of the tissue factor element was dependent on its specific sequence and not simply a high AU nucleotide content. The degradation of unstable chimeric tissue factor.beta-globin mRNAs was prevented by inhibition of transcription with actinomycin D. Chimeric tissue factor.beta-globin mRNAs were superinduced by the protein synthesis inhibitor cycloheximide, and this superinduction may be due in part to stabilization of the mRNA.
Numerical Simulation of Heat Treatment Based on the Model With Expanded Solution Domain (2012)

The heat treating of metals is a very complicated process in which multiple physical variables nonlinearly couple with each other. The heat transfer at gas–solid and liquid–solid interfaces is the most important problem to be solved in the numerical simulation of heat treatment, which is also the basis for the process design and equipment design of heat treatment. The traditional way in which one takes the parts as investigation objects and sets the heat transfer coefficient on the interface directly inevitably brings significant inaccuracy to simulation results. A series of research achievements in fluid mechanics and heat transfer theory have provided effective ways of dealing with this problem in heat treatment modeling. In this paper, a heat treatment model with an expanded solution domain is proposed after a brief summary of related research results for coupled heat transfer. In this model, the solution domain has been expanded to the surroundings of the heat treating parts. Taking the heating process in an industry furnace as an example, not only the parts and fixture but also the furnace body, furnace chamber, heating units, and all other components in the furnace are modeled as a whole. The virtual equipment design for a novel bell-type gas nitriding furnace has been successfully fulfilled based on the heat treatment simulation and demonstrates the giant advantage of this new model. It is necessary to emphasize that as an important step in the numerical simulation of heat treatment, this new model is far from mature, and a series of key problems still remain.
Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse (2012)

Histamine H3 receptor (H3R) antagonists/inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric disorders. This review presents the various neurobiological/neurochemical evidences available so far following H3R antagonists in the pathophysiology of Alzheimer's disease (AD), attention-deficit hyperactivity disorder (ADHD), schizophrenia, and drug abuse each of which is accompanied by deficits of some aspects of cognitive and/or motor functions. Whether the H3R inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits.
Novel cellulose producing system by microorganisms such as Acetobacter sp. (2005)

species produce a gelatinous membrane called a pellicle on the surface of liquid culture, and this membrane is composed of pure cellulose. It was about one century ago that the first scientific paper was written by Brown in 1886 (1) on a peculiar fermentative substance that would have been known in many places on earth and was particularly popular in his country under the name of “vinegar plant”. Under pure cultivation in carbohydrate media, it was observed that the whole surface of the liquid is covered with a gelatinous membrane, which may attain a thickness of 25 mm under favorable circumstances. On removing the membrane from the liquid, it is found to be very tough, especially if an attempt is made to tear it across its plane of growth. From chemical analysis and various reactions, the substance was concluded without doubt to be cellulose, although microscopy at that time only gave a picture of living bacteria embedded in a transparent structureless film. During the following one hundred years, a number of studies have been made on the structure of the pellicle as well as its production. Today, it is known that the pellicle comprises a random assembly of fibrils, less than 130 nm wide, which are composed of a bundle of much finer microfibrils that are 2 to 4 nm in diameter (2, 3). It is also known that the pellicle gives a film or sheet if it is dried. The crystallographic form of this cellulose has been almost the same as that of “cellulose I,” commonly found in plant cellulose, and the molecular orientation is parallel to the direction of cellulose chain axis (4, 5). Such a peculiar super-molecular structure engineered by nature has come to be of great interest to the present author when compared with other synthetic polymers that have been created to make super-strong fibers during the last two decades. Bacterial cellulose has been found to have unique structural and physical
Magnetic noise associated with ocean internal waves (2009)

Environmental noise can be a major limitation on the performance of magnetic sensor systems in continental shelf regions. Previous work has predicted the magnetic influence from internal waves and indicates that these could be important components of ambient ocean magnetic noise. Existing electric and magnetic field sensor technology has an instrument noise floor well below the ambient magnetic noise in shallow water applications. Model predictions indicate that internal oceanographic features, such as high amplitude internal waves, internal bores and solitary waves, can contribute magnetic variations in the very low frequency band ranging from 0.1 to 1.0 nT which is well above the noise level of commercial magnetometer systems. Predictions of the magnetic character for internal ocean dynamics are computed using a nested non-hydrostatic ocean model coupled with a simple electromagnetic model. These predictions should correlate with oceanographic observations of water velocity. Comparison of the model predictions with observed oceanographic measurements is under investigation.
Alterations in Atrial Electrophysiology and Tissue Structure in a Canine Model of Chronic Atrial Dilatation Due to Mitral Regurgitation (2003)

Chronic atrial dilatation in the absence of overt heart failure leads to an increased vulnerability to AF that is not based on a decrease in wavelength.
Heat Treatment for Vane of OCr17Ni4Cu4Nb Steel (2003)

Martensite preciptation -hardening stainless steel OCrl7Ni4Cu4Nb is possessed of fine synthetic mechan- ical properties. The mechanical properties necessary to the vane will be achieved by means of solution treafment and double aging. The test results show that the steel is highly sensitive to heat treatment temperature, and grain size has slight influence on fatigue property of the steel.