gebhart/patrepeval huggingface dataset:
Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. (1991)

Direct oxygen partial pressure (pO2) readings in cancers of the cervix and in the normal cervix of nulliparous or parous women were obtained using a computerized pO2 histography system. The oxygenation status of the tumors was evaluated as a function of clinical staging and histological grading. pO2 measurements were performed with a customized electrode system in conscious pre- and postmenopausal, untreated patients with well-defined arterial blood gas status. With this technique, pO2 measurements in the normal cervix of nulliparous women resulted in oxygenation patterns which were characteristic for normal, adequately supplied tissues (median pO2, 48 mm Hg) with approximately 1% of the pO2 values grouped between zero and 2.5 mm Hg, i.e., in a range with less than half-maximum radiosensitivity. As a rule, the mean (and median) pO2 values were distinctly lower in the normal cervix of parous women (most probably due to scar formation following vaginal delivery) and in malignancies. In the normal cervix of parous women the median pO2 value was 13 mm Hg (with approximately 14% of the pO2 readings in the lowest class), 14 mm Hg in International Federation of Gynecologists and Obstetricians I/II tumors (2% of the readings in the lowest pO2 class), and 11 mm Hg in International Federation of Gynecologists and Obstetricians III/IV cancers (1% of the pO2 data in the lowest class). To date, 5 of 18 cervical cancers exhibited pO2 values between zero and 2.5 mm Hg. The oxygenation pattern in cervical cancers and the occurrence of hypoxia and/or anoxia did not correlate with either the clinical stages and histological grades or with a series of clinically relevant parameters (e.g., tumor size). No significant differences were found between pre- and postmenopausal tumors, between squamous cell carcinomas and adenocarcinomas, and between endophytic or exophytic tumors. From these studies there is clear indication that the oxygenation status of individual tumors cannot be predicted on the basis of staging and/or grading, predominantly because of the pronounced tumor-to-tumor variabilities. Evaluation of the tissue oxygenation of individual tumors is thus mandatory to prove that tumor oxygenation can predict the overall prognosis and/or treatment outcome.
Restriction fragment length polymorphism analysis of variation in <i>Fusarium</i> species causing ear blight of cereals (1993)

Genetic variation in Fusarium species on wheat was investigated using restriction fragment length polymorphism (RFLP) analysis. Single‐spore lines (76) of Fusarium were recovered from 24 ears of wheat in a field plot exhibiting severe symptoms of Fusarium ear blight and identified using classical taxonomic criteria. Four Fusarium species were present, of which F. avenaceum and F. culmorum were predominant with F. lateritium and F. poae present in two ears and one ear, respectively. RFLP analysis using rDNA (pTA71) or total genomic DNA from an F. culmorum isolate clearly distinguished the four species. Genetic fingerprints of the isolates generated using DNA of bacteriophage M13 (which contains a mini‐satellite repeat sequence) revealed considerable variation within three of the four species (except F. poae). Generally, only a single clone was recovered from each ear and in all but one case only a single species was obtained from each spikelet. However, in several instances it appeared that more than one clone of a species was present within a single spikelet.
Treatment of Acromegaly with the Long-Acting Somatostatin Analog SMS 201-995* (1988)

Current treatment of acromegaly (surgery, radiation, and bromocriptine) is often unsatisfactory, and a sizeable proportion of patients with this disease continue to have GH hypersecretion after all therapeutic modalities have been exhausted. Fifteen patients with active acromegaly (8 previously treated and 7 newly diagnosed) were treated with the long-acting somatostatin analog SMS 201-995 (Sandoz; 50-250 micrograms, sc, every 6-8 h for up to 21 months). The mean daily plasma GH concentration was significantly suppressed in 13 patients, and it became normal in 10. Two patients, however, did not have GH suppression by SMS 201-995 treatment alone; in 1, a significant decline in mean daily GH was achieved after the addition of bromocriptine. As expected, suppression of GH secretion was associated with normalization of plasma somatomedin-C values and significant clinical improvement. Plasma GH responses to synthetic GHRH-(1-44) and TRH were either abolished or blunted by SMS 201-995. Thyroid function remained normal, and glucose tolerance did not change. Significant shrinkage of pituitary tumors occurred in 7 previously untreated and 2 previously treated patients. Side-effects were minimal. SMS 201-995 is an effective agent for the treatment of acromegaly. Further studies are necessary to establish guidelines for identification of non-responders and to examine the effect of preoperative tumor shrinkage on subsequent surgical outcome.
Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors (2005)

Disruption of the systemic angiogenesis balance to favor enhanced angiogenesis is speculated to represent a key step in the growth of tumors. Although a major emphasis has been placed on the increase of angiogenesis stimulators, such as VEGF, on the disruption of the angiogenic balance, the potential role of the physiological levels of endogenous inhibitors of angiogenesis on tumor growth is poorly understood. Here, we use three independent lines of mice deficient in tumstatin, endostatin, or thrombospondin-1 (TSP-1), to address the role that these endogenous angiogenesis inhibitors play in tumor growth. Our experiments demonstrate that normal physiological levels of these inhibitors serve to retard the growth of tumors, and that their absence leads to enhanced angiogenesis and a 2- to 3-fold increase in tumor growth. The tumor-suppressive action of TSP-1, endostatin, and tumstatin correlates with expression of CD36 receptor, alpha5beta1 integrin, and alphavbeta3 integrin on proliferating endothelial cells, respectively. Moreover, tumors grow 2-fold faster in the tumstatin/TSP-1 double-knockout mice, compared with either the tumstatin- or the TSP-1-deficient mice, strongly suggesting that ceiling rate of cancer growth is not completely dependent on the genetic defects of cancer cells but also depends on the host-derived tumor microenvironment. Additionally, tumor growth in transgenic mice overproducing endostatin specifically in the endothelial cells (a 1.6-fold increase in the circulating levels; mimicking Down's syndrome condition) is 3-fold slower than the tumor growth in wild-type mice. Collectively, our data suggest that physiological levels of endogenous inhibitors of angiogenesis can serve as endothelium-specific tumor suppressors.
Non-blocking, localized routing algorithm for balanced energy consumption in mobile ad hoc networks (2002)

As mobile computing requires more computation as well as communication activities, energy efficiency becomes the most critical issue for battery-operated mobile devices. Specifically, in ad hoc networks where each node is responsible for forwarding neighbor nodes' data packets, care has to be taken not only to reduce the overall energy consumption of all relevant nodes but also to balance individual battery levels. Unbalanced energy usage will result in earlier node failure in overloaded nodes, and in turn may lead to network partitioning and reduced network lifetime. This paper presents a new routing algorithm, called local energy-aware routing (LEAR), which achieves a trade-off between balanced energy consumption and shortest routing delay, and at the same time avoids the blocking and route cache problems. Our performance study based on GloMoSim simulator shows that compared to DSR the proposed LEAR improves the energy balance 1.0-35% depending on node mobility.
Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4) (2015)

Ring finger protein 4 (RNF4) is a SUMO-targeted ubiquitin E3 ligase with a pivotal function in the DNA damage response (DDR). SUMO interaction motifs (SIMs) in the N-terminal part of RNF4 tightly bind to SUMO polymers, and RNF4 can ubiquitinate these polymers in vitro. Using a proteomic approach, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-component, as a functional interactor of RNF4. USP11 can deubiquitinate hybrid SUMO-ubiquitin chains to counteract RNF4. SUMO-enriched nuclear bodies are stabilized by USP11, which functions downstream of RNF4 as a counterbalancing factor. In response to DNA damage induced by methyl methanesulfonate, USP11 could counteract RNF4 to inhibit the dissolution of nuclear bodies. Thus, we provide novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR.
The Effect of Structure on the Course of Phosphoryl Chloride-Pyridine Dehydration of Tertiary Alcohols (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Effect of Structure on the Course of Phosphoryl Chloride-Pyridine Dehydration of Tertiary AlcoholsRonald R. SauersCite this: J. Am. Chem. Soc. 1959, 81, 18, 4873–4876Publication Date (Print):September 1, 1959Publication History Published online1 May 2002Published inissue 1 September 1959https://pubs.acs.org/doi/10.1021/ja01527a028https://doi.org/10.1021/ja01527a028research-articleACS PublicationsRequest reuse permissionsArticle Views852Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. (1993)

In this study we have examined the effects of interleukin 10 (IL-10) on polymorphonuclear leukocytes (PMN), and found that it is a potent inhibitor of tumor necrosis factor (TNF), IL-1 beta, and IL-8 secretion triggered by lipopolysaccharide (LPS). Cytokine production by phagocytosing PMN was also inhibited by IL-10, but to a lesser extent than the LPS-induced production. As shown by Northern blot analysis, IL-10 diminished the levels of TNF, IL-1 beta, and IL-8 mRNAs late after the onset of stimulation of PMN with LPS. In addition, we provide evidence that the kinetics of LPS-induced IL-8 production by PMN is composed of two distinct phases. Specifically, our experiments demonstrated that in the first phase, the production of IL-8 is a process directly induced by LPS that lasts for some hours. After this early wave, a second phase begins that is sustained and leads to an elevated production of IL-8 that appears to be due to the endogenous release of TNF and IL-1 beta. This second wave can in fact be blocked by anti-TNF and anti-IL-1 beta neutralizing antibodies, and by IL-10 as the consequence of its downregulatory effects on TNF and IL-1 beta release. Taken together, these findings identify novel biological actions of IL-10 as a suppressor of the inflammatory response.
Novel Chimeric Genotype 1b/2a Hepatitis C Virus Suitable for High-Throughput Screening (2007)

A major obstacle in hepatitis C virus (HCV) research has been the lack of a permissive cell culture system that produces infectious viral particles. Significant breakthroughs have been achieved lately in establishing such culture systems. Yet to date, there are no reports of the applications of any of these systems in HCV drug screening. Here, we report the generation of two monocistronic, chimeric genotype 1 full-length HCV genome molecules. These molecules, C33J-Y835C-UBI and C33J-Y835C-FMDV2A, both contain the structural protein region from genotype 1 (subtype 1b, Con1) and the remaining region from the genotype 2a (JFH1) clone. Both contain the humanized Renilla luciferase reporter gene which is separated from the rest of the HCV open reading frame by two different cleavage sites. The viral RNAs replicated efficiently in transfected cells. Viral particles produced were infectious in naïve Huh7.5 cells, and the infectivity could be blocked by monoclonal antibody against a putative HCV entry cofactor, CD81. A pilot high-throughput screen of 900 unknown compounds was executed by both the genotype 2a subgenomic replicon system and the infectious system. Thirty-one compounds were identified as hits by both systems, whereas 78 compounds were identified as hits only for the infectious system, suggesting that the infectious system is capable of identifying inhibitors targeting the viral structural proteins and steps involving them in the viral life cycle. The infectious HCV system developed here provides a useful and versatile tool which should greatly facilitate the identification of HCV inhibitors currently not identified by the subgenomic replicon system.
ELISA System for Human Endothelial Lipase (2012)

This ELISA should be useful for clarifying the impact of EL on HDL metabolism and EL's potential role in atherosclerosis.
Effect of acid evaporation in chemically amplified resists on insoluble layer formation. (1995)

This paper concerns the acid evaporation caused by the baking treatment of chemically amplified resists. The evaporation of photogenerated acid during the post-exposure-baking (PEB) process was measured as a spectral change of indicator film that consisted of polyvinyl alcohol (PVA) and tetrabromophenol blue sodium salt (TBPB). Using this method, it was observed that the amount of evaporated acid depended on the pre-baking and PEB conditions. A high temperature pre-baking before exposure reduced the amount of evaporated acid. By contrast, a high temperature PEB accelerated the acid evaporation, and the thickness of the insoluble layer increases with increasing PEB temperature. These results suggest that acid evaporation is concerned with the formation of the insoluble layer.
Inhibiting the<scp>DNA</scp>damage response as a therapeutic manoeuvre in cancer (2013)

This article is part of a themed section on Emerging Therapeutic Aspects in Oncology. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2013.169.issue-8.
Replicating the Blue Wool Response Using a Smartphone Spectroradiometer (2017)

A spectroradiometer was developed using the rear camera of the Samsung S7 smartphone for replicating the response of blue wool, a light comparative fading test from the textile industry that was adopted by the art conservation community in the 1960s. This technique was regarded as a cost effective, readily available comparative standard for understanding lightfastness of museum objects, but not an end all solution. Many other solutions have been found since the suggestion of the blue wool standard. Including the Canadian Light Damage Calculator and Lightcheck® ,which are comparator guides for lighting museum objects. The Berlin model for comparing tested spectral data is taken with expensive equipment, to a database to determine an objects sensitivity. Microfadeometry that directly tests the object with a 0.4-mm diameter focused Xenon source that deteriorates the artwork. None however have been able to completely replace the vetted, cost effective, easy to use blue wool standard for determining the sensitivity of museum and gallery objects, but a solution is needed. The solution is a designed and tested smartphone spectroradiometer attachment that measures the illumination and reflectance spectrum of museum and gallery objects to deduce an absorption spectrum that can be correlated to an expected blue wool response under the same conditions. The attachment for the phone is made from off the shelf and 3D printed parts. It has measured the deterioration of blue wool under a high intensity source and can predict the expected time for a blue wool specimen to visibly fade under the illumination of museum LED lighting. This thesis covers the design, modeling and testing experiment for the smartphone spectroradiometer that currently has a resolution of ± 7 nm, a spectral range from 393 to 650 nm with five orders of magnitude and an absolute radiometric error of 27.5% with the possibility of room for improvement. This includes increasing the accuracy of the modeled spectrum of the sun used for calibration, applying more advanced noise removal techniques, applying filters in post processing for better resolution and of course using a smartphone that takes raw images and can have its optical image stabilizer turned off during manual mode.
Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate. (2000)

At high fluence rates in animal models, photodynamic therapy (PDT) can photochemically deplete ambient tumor oxygen through the generation of singlet oxygen, causing acute hypoxia and limiting treatment effectiveness. We report that standard clinical treatment conditions (1 mg/kg Photofrin, light at 630 nm and 150 mW/cm2), which are highly effective for treating human basal cell carcinomas, significantly diminished tumor oxygen levels during initial light delivery in a majority of carcinomas. Oxygen depletion could be found during at least 40% of the total light dose, but tumors appeared well oxygenated toward the end of treatment. In contrast, initial light delivery at a lower fluence rate of 30 mW/cm2 increased tumor oxygenation in a majority of carcinomas. Laser treatment caused an intensity- and treatment time-dependent increase in tumor temperature. The data suggest that high fluence rate treatment, although effective, may be inefficient.
Alu-Alu Fusion Sequences Identified at Junction Sites of Copy Number Amplified Regions in Cancer Cell Lines (2012)

Alu elements are short, ∼300-bp stretches of DNA and are the most abundant repetitive elements in the human genome. A large number of chromosomal rearrangements mediated by Alu-Alu recombination have been reported in germline cells, but only a few in somatic cells. Cancer development is frequently accompanied by various chromosomal rearrangements including gene amplification. To explore an involvement of Alu-Alu fusion in gene amplification events, we determined 20 junction site sequences of 5 highly amplified regions in 4 cancer cell lines. The amplified regions exhibited a common copy number profile: a stair-like increase with multiple segments, which is implicated in the breakage-fusion-bridge (BFB) cycle-mediated amplification. All of the sequences determined were characterized as head-to-head or tail-to-tail fusion of sequences separated by 1-5 kb in the genome sequence. Of these, 4 junction site sequences were identified as Alu-Alu fusions between inverted, paired Alu elements with relatively long overlapping sequences of 17, 21, 22, and 24 bp. Together with genome mapping data of Alu elements, these findings suggest that when breakages occur at or near inverted, paired Alu elements in the process of BFB cycle-mediated amplification, sequence homology of Alu elements is frequently used to repair the broken ends.
High fan-in dynamic cmos comparators with low transistor count (2003)

In this work, we propose several high fan-in dynamic CMOS comparators with low transistor count, high speed and low power. Major features of the proposed comparators are the rearrangement and reordering of transistors in the evaluation block of a dynamic cell. These comparators can be used as equality comparators, mutual comparators and zero/one detectors, which are widely used in built in self test and memory testing. Furthermore, a 64-bit fast dynamic CMOS comparator is implemented using the proposed dynamic comparator. The measured worst delay of the physical chip with pads is 12 ns.
Phase I Trial of Temozolomide and Protracted Irinotecan in Pediatric Patients with Refractory Solid Tumors (2004)

The MTD using this schedule was temozolomide (100 mg/m(2)/day) and irinotecan (10 mg/m(2)/day), with DLT being diarrhea and infection. Drug clearance was similar to single-agent values, and clinically relevant SN-38 lactone and MTIC exposures were achieved at the MTD. As predicted by xenograft models, this combination and schedule appears to be tolerable and active in pediatric solid tumors. Evaluation of a 21-day schedule is planned.
Efficiently compiling efficient query plans for modern hardware (2011)

As main memory grows, query performance is more and more determined by the raw CPU costs of query processing itself. The classical iterator style query processing technique is very simple and exible, but shows poor performance on modern CPUs due to lack of locality and frequent instruction mispredictions. Several techniques like batch oriented processing or vectorized tuple processing have been proposed in the past to improve this situation, but even these techniques are frequently out-performed by hand-written execution plans. In this work we present a novel compilation strategy that translates a query into compact and efficient machine code using the LLVM compiler framework. By aiming at good code and data locality and predictable branch layout the resulting code frequently rivals the performance of hand-written C++ code. We integrated these techniques into the HyPer main memory database system and show that this results in excellent query performance while requiring only modest compilation time.
Ta2O5 Interfacial Layer between GST and W Plug enabling Low Power Operation of Phase Change Memories (2006)

A novel memory cell for phase-change memories (PCMs) that enables low-power operation has been developed. Power (i.e., current and voltage) for the cell is significantly reduced by inserting a very thin Ta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> film between GeSbTe (GST) and a W plug. The Ta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> interfacial layer works not only as a heat insulator enabling effective heat generation in GST but also as an adhesion layer between GST and SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> underneath. Nonetheless, sufficient current flows through the interfacial layer due to direct tunneling. A low programming power of 1.5 V/100 muA can therefore be obtained even on a W plug with a diameter of 180 nm fabricated using standard 0.13-mum CMOS technology. In addition, the uniformity and repeatability of cell resistance are excellent because of the inherently stable Ta <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> film properties