gebhart/patrepeval huggingface dataset:
Model Predictive Control of a Fuel Injection System with a Radial Basis Function Network Observer (2002)

This paper proposes a new Model Predictive Control scheme incorporating a Radial Basis Function Network Observer for the fuel injection problem. Two new contributions are presented here. First a Radial Basis Function Network is used as an observer for the air system. This allows for gradual adaptation of the observer, ensuring the control scheme is capable of maintaining good performance under changing engine conditions brought about by engine wear, variations between individual engines, and other similar factors. The other major contribution is the use of model predictive control algorithms to compensate for the fuel pooling effect on the intake manifold walls. Two model predictive control algorithms are presented which enforce input, and input and state constraints. In this way stability under the constraints is guaranteed. A comparison between the two constrained MPC algorithms is qualitatively presented, and conclusions are drawn about the necessity of constraints for the fuel injection problem. Simulation results are presented that demonstrate the effectiveness of the control scheme, and the proposed control approach is validated on a four-cylinder spark ignition engine.
γ-Secretase is Differentially Modulated by Alterations of Homocysteine Cycle in Neuroblastoma and Glioblastoma Cells (2007)

Multiple aspects of homocysteine metabolism were studied to understand the mechanism responsible for hyperhomocysteinemia toxicity in Alzheimer disease. Besides oxidative stress and vascular damage, homocysteine has also a great importance in regulating DNA methylation through S-adenosylmethionine, the main methyl donor in eukaryotes. Alterations of S-adenosylmethionine and methylation were evidenced in Alzheimer disease and in elderly. In order to clarify whether DNA methylation can provide the basis for amyloid-beta overproduction, we used human SK-N-BE neuroblastoma and A172 glioblastoma cell lines. We tested the effects of folate, B12 and B6 deprivation and S-adenosylmethionine addition on methylation metabolism. Our results indicate that homocysteine accumulation induced through vitamin B deprivation could impair the "Methylation Potential" with consequent presenilin 1, BACE and amyloid-beta upregulation. Moreover, we found that homocysteine alterations had an effect on neuroblastoma but not on glioblastoma cells; this suggests a possible differential role of the two cell types in Alzheimer disease.
Robust MIL-Based Feature Template Learning for Object Tracking (2017)

Because of appearance variations, training samples of the tracked targets collected by the online tracker are required for updating the tracking model. However, this often leads to tracking drift problem because of potentially corrupted samples: 1) contaminated/outlier samples resulting from large variations (e.g. occlusion, illumination), and 2) misaligned samples caused by tracking inaccuracy. Therefore, in order to reduce the tracking drift while maintaining the adaptability of a visual tracker, how to alleviate these two issues via an effective model learning (updating) strategy is a key problem to be solved. To address these issues, this paper proposes a novel and optimal model learning (updating) scheme which aims to simultaneously eliminate the negative effects from these two issues mentioned above in a unified robust feature template learning framework. Particularly, the proposed feature template learning framework is capable of: 1) adaptively learning uncontaminated feature templates by separating out contaminated samples, and 2) resolving label ambiguities caused by misaligned samples via a probabilistic multiple instance learning (MIL) model. Experiments on challenging video sequences show that the proposed tracker performs favourably against several state-of-the-art trackers.
The Light Reactions of Photosynthesis (1971)

Historically, the role of light in photosynthesis has been ascribed either to a photolysis of carbon dioxide or to a photolysis of water and a resultant rearrangement of constituent atoms into molecules of oxygen and glucose (or formaldehyde). The discovery of photophosphorylation demonstrated that photosynthesis includes a light-induced phosphorus metabolism that precedes, and is independent from, a photolysis of water or CO(2). ATP formation could best be accounted for not by a photolytic disruption of the covalent bonds in CO(2) or water but by the operation of a light-induced electron flow that results in a release of free energy which is trapped in the pyrophosphate bonds of ATP. Photophosphorylation is now divided into (a) a non-cyclic type, in which the formation of ATP is coupled with a light-induced electron transport from water to ferredoxin and a concomitant evolution of oxygen and (b) a cyclic type which yields only ATP and produces no net change in the oxidation-reduction state of any electron donor or acceptor. Reduced ferredoxin formed in (a) serves as an electron donor for the reduction of NADP by an enzymic reaction that is independent of light. ATP, from both cyclic and noncyclic photophosphorylation, and reduced NADP jointly constitute the assimilatory power for the conversion of CO(2) to carbohydrates (3 moles of ATP and 2 moles of reduced NADP are required per mole of CO(2)).Investigations, mainly with whole cells, have shown that photosynthesis in green plants involves two photosystems, one (System II) that best uses light of "short" wavelength (lambda < 685 nm) and another (System I) that best uses light of "long" wavelength (lambda > 685 nm). Cyclic photophosphorylation in chloroplasts involves a System I photoreaction. Noncyclic photophosphorylation is widely held to involve a collaboration of two photoreactions: a short-wavelength photoreaction belonging to System II and a long-wavelength photoreaction belonging to System I. Recent findings, however, indicate that noncyclic photophosphorylation may include two short-wavelength, System II, photoreactions that operate in series and are joined by a "dark" electron-transport chain to which is coupled a phosphorylation site.
<i>Eupatorium Capillifolium</i> Essential Oil: Chemical Composition, Antifungal Activity, and Insecticidal Activity (2010)

Natural plant extracts often contain compounds that are useful in pest management applications. The essential oil of Eupatorium capillifolium (dog-fennel) was investigated for antifungal and insecticidal activities. Essential oil obtained by hydrodistillation of aerial parts was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS). The major components were determined to be thymol methyl ether (=methyl thymol) (36.3%), 2,5-dimethoxy-p-cymene (20.8%) and myrcene (15.7%). Antifungal activity of the essential oil was weak against the plant pathogens Colletotrichum acutatum, C. fragariae, and C. gloeosporioides in direct bioautography assay. The E. capillifolium oil showed promising repellent activity against the yellow fever mosquito Aedes aegypti, whereas the oil exhibited moderate activity against the mosquito's first instar larvae in a high throughput bioassay. Topical applications of the oil showed no activity against the blood-feeding female adults of A. aegypti. Eupatorium capillifolium essential oil showed a linear dose response between adult lace bug (Stephanitis pyrioides) mortality and increasing oil concentration in an adulticidal activity bioassay. The dog-fennel oil was more potent than the conventional insecticide malathion. In conclusion, these combined results showed Eupatorium capillifolium oil is a promising novel source of a biological insecticide with multiple modes of action.
The potential for operational research (2009)

Operational research embodies a wide range of techniques that can improve the way we plan and organise health services. So, why have these tools not been more widely adopted in the NHS? To answer this we need to understand the key structural barriers to implementation, only then can we address the key issues and begin to realise this untapped potential.
Nanoliter Dispensing on Pipetting Workstations by Disposable PipeJet-Tips (2012)

We present a liquid handling system for the contact-free application of liquid volumes in the nanoliter range. The droplet generation mechanism is based on the PipeJet TM technology [1, 2] but applies a new kind of disposable pipetting tip, termed PipeJet-tip. A piezo stack driven piston squeezes the lower part of the tip, an elastic tube with an inner diameter of 650 � m, to generate free-flying droplets with volumes down to 20 nl (CV < 5%). This technology is applicable to dispense liquids of a wide range of rheology. Liquids like water, DMSO and 50% glycerol/water mixtures have been dispensed successfully. In addition, even volumes in the microliter range can be delivered by the ejection of multiple droplets at frequencies up to 50 Hz. The PipeJettips are fabricated by injection moulding, which enables low cost, disposable products. The actuation unit automatically locks the tips which are loaded into the unit by a pipette handling robot. The parts which are in contact with the liquid are automatically exchangeable. The presented system is fully compatible with existing pipetting workstations
Promutagen activation by freshly isolated and cryopreserved rat hepatocytes (1988)

The metabolic activation of promutagens by freshly isolated and cryopreserved rat hepatocytes was compared using the Chinese hamster ovary/hypoxanthine-guanine phosphoribosyltransferase assay (CHO/HGPRT). Cryopreserved rat hepatocytes were equivalent to freshly isolated hepatocytes in their ability to metabolize dimethylbenz(a)anthracene (DMBA) and dimethylnitrosamine (DMN) to active mutagens. Similar dose-response curves were observed using either freshly isolated or cryopreserved hepatocytes as activating systems after treatment with DMBA (0.1-1 micrograms/ml) and DMN (0.075-0.6 mg/ml). Our results suggest that cryopreserved hepatocytes are similar to freshly isolated hepatocytes as an experimental system for studies on promutagen activation.
Unbalanced Expanders and Randomness Extractors from Parvaresh-Vardy Codes (2007)

We give an improved explicit construction of highly unbalanced bipartite expander graphs with expansion arbitrarily close to the degree (which is polylogarithmic in the number of vertices). Both the degree and the number of right-hand vertices are polynomially close to optimal, whereas the previous constructions of Ta-Shma, Umans, and Zuckerman (STOC "01) required at least one of these to be quasipolynomial in the optimal. Our expanders have a short and self-contained description and analysis, based on the ideas underlying the recent list-decodable error-correcting codes of Parvaresh and Vardy (FOCS "05). Our expanders can be interpreted as near-optimal "randomness condensers," that reduce the task of extracting randomness from sources of arbitrary min-entropy rate to extracting randomness from sources of min-entropy rate arbitrarily close to 1, which is a much easier task. Using this connection, we obtain a new construction of randomness extractors that is optimal up to constant factors, while being much simpler than the previous construction of Lu et al. (STOC "03) and improving upon it when the error parameter is small (e.g. 1/poly(n)).
Insights into the Interplay of Lewis and Brønsted Acid Catalysts in Glucose and Fructose Conversion to 5-(Hydroxymethyl)furfural and Levulinic Acid in Aqueous Media (2013)

5-(Hydroxymethyl)furfural (HMF) and levulinic acid production from glucose in a cascade of reactions using a Lewis acid (CrCl3) catalyst together with a Brønsted acid (HCl) catalyst in aqueous media is investigated. It is shown that CrCl3 is an active Lewis acid catalyst in glucose isomerization to fructose, and the combined Lewis and Brønsted acid catalysts perform the isomerization and dehydration/rehydration reactions. A CrCl3 speciation model in conjunction with kinetics results indicates that the hydrolyzed Cr(III) complex [Cr(H2O)5OH](2+) is the most active Cr species in glucose isomerization and probably acts as a Lewis acid-Brønsted base bifunctional site. Extended X-ray absorption fine structure spectroscopy and Car-Parrinello molecular dynamics simulations indicate a strong interaction between the Cr cation and the glucose molecule whereby some water molecules are displaced from the first coordination sphere of Cr by the glucose to enable ring-opening and isomerization of glucose. Additionally, complex interactions between the two catalysts are revealed: Brønsted acidity retards aldose-to-ketose isomerization by decreasing the equilibrium concentration of [Cr(H2O)5OH](2+). In contrast, Lewis acidity increases the overall rate of consumption of fructose and HMF compared to Brønsted acid catalysis by promoting side reactions. Even in the absence of HCl, hydrolysis of Cr(III) decreases the solution pH, and this intrinsic Brønsted acidity drives the dehydration and rehydration reactions. Yields of 46% levulinic acid in a single phase and 59% HMF in a biphasic system have been achieved at moderate temperatures by combining CrCl3 and HCl.
Depth of Proteome Issues (2004)

As a test case for optimizing how to perform proteomics experiments, we chose a yeast model system in which the UPF1 gene, a protein involved in nonsense-mediated mRNA decay, was knocked out by homologous recombination. The results from five complete isotope-coded affinity tag (ICAT) experiments were combined, two using matrix-assisted laser desorption/ionization (MALDI) tandem mass spectrometry (MS/MS) and three using electrospray MS/MS. We sought to assess the reproducibility of peptide identification and to develop an informatics structure that characterizes the identification process as well as possible, especially with regard to tenuous identifications. The cleavable form of the ICAT reagent system was used for quantification. Most proteins did not change significantly in expression as a consequence of the upf1 knockout. As expected, the Upf1 protein itself was down-regulated, and there were reproducible increases in expression of proteins involved in arginine biosynthesis. Initially, it seemed that about 10% of the proteins had changed in expression level, but after more thorough examination of the data it turned out that most of these apparent changes could be explained by artifacts of quantification caused by overlapping heavy/light pairs. About 700 proteins altogether were identified with high confidence and quantified. Many peptides with chemical modifications were identified, as well as peptides with noncanonical tryptic termini. Nearly all of these modified peptides corresponded to the most abundant yeast proteins, and some would otherwise have been attributed to "single hit" proteins at low confidence. To improve our confidence in the identifications, in MALDI experiments, the parent masses for the peptides were calibrated against nearby components. In addition, five novel parameters reflecting different aspects of identification were collected for each spectrum in addition to the Mascot score that was originally used. The interrelationship between these scoring parameters and confidence in protein identification is discussed.
Immunization of melanoma patients with BEC2-keyhole limpet hemocyanin plus BCG intradermally followed by intravenous booster immunizations with BEC2 to induce anti-GD3 ganglioside antibodies. (1999)

BEC2 is an anti-idiotypic mouse monoclonal antibody that mimics GD3 ganglioside. Previous clinical trials demonstrated that intradermal immunization using 2.5 mg of BEC2 with BCG or i.v. immunization with 10 mg of BEC2 can induce anti-GD3 antibodies in a subset of patients. We hypothesized that combining these two immunization strategies might be more effective in inducing anti-GD3 antibodies and that conjugation of BEC2 to keyhole limpet hemocyanin (KLH) would further enhance the immunogenicity of BEC2. In this clinical trial, 18 melanoma patients who were free of disease after complete surgical resection within 1-6 months received intradermal immunizations on weeks 0, 2, 4, 6, and 10 with 2.5 mg of BEC2 conjugated to KLH and mixed with BCG (BEC2-KLH/BCG). Booster immunizations of 10 mg of unconjugated BEC2 were administered i.v. on weeks 24, 37, and 50. Four of 18 patients (22%) developed IgM anti-GD3 antibodies. No IgG anti-GD3 antibodies were detected. All four responding patients developed anti-GD3 IgM during immunization with BEC2-KLH/BCG; only one patient demonstrated a reboost of the IgM anti-GD3 titer during the i.v. immunizations. Thirteen of the patients are free of melanoma (3 after undergoing re-resection for local relapse); 14 patients (78%) remain alive with a median follow-up of 28 months. These results confirm our previous trial, showing that BEC2 with BCG can induce anti-GD3 antibodies in patients. The data do not provide evidence that conjugation to KLH increases the immunogenicity of BEC2 when it is administered with BCG.
Improvements in electrical and electrochemical properties of Nb-doped SnO<sub>2−δ</sub> supports for fuel cell cathodes due to aggregation and Pt loading (2014)

We found the specific activities of Pt/Sn<sub>0.96</sub>Nb<sub>0.04</sub>O<sub>2−δ</sub> for the oxygen reduction reaction increased with increasing conductivity of the support.
Shallow silicide contacts formed by using codeposited Pt2Si and Pt1.2Si films (1980)

We have succeeded in making shallow silicide contacts on Si by using codeposited Pt2Si and Pt1.2Si alloyed films. Cross-sectional transmission electron microscopy showed that a uniform contact 10 nm deep was achieved by both films. Current-voltage measurements showed that the Schottky barrier height of these shallow contacts was as good as that of PtSi made by reacting pure Pt with n-Si.
Anatomy, histochemistry and oxalic acid content of the leaflets of Averrhoa bilimbi and Averrhoa carambola (2018)

Averrhoa bilimbi L. and A. carambola L., Oxalidaceae, are the only two species of the genus Averrhoa L. Their leaves are widely used in folk medicine as an adjuvant in the treatment of diabetes. Some species may contain, for example, calcium oxalate crystals, which may lead to risk in its use when there is predisposition of individuals with reduced renal activity. Therefore, there are still few studies on the content of oxalic acid present in them, highlighting the importance of this investigation. The objective of this work was to conduct a comparative anatomical and histochemical study between the species and determining its content of oxalic acid. Semipermanent histological slides were prepared, following common plant anatomy procedures, for analysis of the leaflets in optical microscopy, polarization and scanning electron microscopy coupled with energy-dispersive X-ray spectrometry. To determine the total, soluble and insoluble oxalate content was used titration with potassium permanganate. The anatomical characterization allowed identifying the characters useful in the differentiation of the species. The histochemistry revealed the location of the metabolites. Chemical microanalyses demonstrated that the crystals are of calcium oxalate. A. carambola presented the highest levels of total oxalate and soluble oxalate. The study assists in the identification and quality control of A. bilimbi and A. carambola and brings new data on its oxalic acid content, which are important, in view of the medicinal use of the species.
Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni (2009)

Isolates of S. mansoni from some patients in Kisumu have lower susceptibility to PZQ, including one from a patient who was never fully cured after repeated rounds of treatment administered over several years. As use of PZQ continues, continued selection for worms with diminished susceptibility is possible, and the probability of emergence of resistance will increase as large reservoirs of untreated worms diminish. The potential for rapid emergence of resistance should be an important consideration of treatment programs.
Tank-mix Combinations for Weed Control in Stale Seedbed Soybean (<i>Glycine max</i>) (1992)

Field experiments were established in 1989 and 1990 on silty clay and sandy loam soils to evaluate selective herbicides in combination with non-selective weed control measures in conventional and stale seedbed soybean production. Metribuzin PRE followed by chlorimuron POST controlled sicklepod better with paraquat than with glyphosate. A POST application of imazaquin increased sicklepod and pitted morningglory control by imazaquin PRE alone in a stale seedbed or tillage program. Pitted morningglory control with imazaquin PRE was lower with tillage than with glyphosate or paraquat combinations in a stale seedbed program. All metribuzin plus chlorimuron PRE treatments, whether conventional tillage or stale seedbed, controlled pitted morningglory more than 75%. Hemp sesbania control was above 80% with all metribuzin followed by chlorimuron or metribuzin plus chlorimuron PRE combinations, and less than 70% with all treatments containing imazaquin. Selective herbicides increased yield in stale seedbed when glyphosate or paraquat was added. Imazaquin PRE, imazaquin PRE followed by imazaquin POST, and metribuzin PRE followed by chlorimuron POST tank mixed with glyphosate or paraquat in a stale seedbed program increased yield compared with the same treatments used with tillage.
Lasers and their Application to Navigation (1964)

The navigator at the present time relies greatly on both optical devices and on radio systems utilizing electromagnetic waves ranging in wavelength from millimetres up to hundreds of metres. The laser extends the coherent properties of radio waves into the visible part of the spectrum. It is natural therefore to expect that this increased facility should lead to the possibility of devising systems based on the laser which might help to overcome problems that still exist in navigation. It is the purpose of this paper to describe the principles and performance of present-day lasers, to survey some of the techniques used in navigation in order to discover those in which the laser might conceivably play a useful part, and to comment on the laser's advantages and disadvantages in comparison with existing methods. Finally, a particular form of laser called the ‘ring laser’ is described and discussed in some detail. The ring laser is of great interest in that it provides a completely novel way of measuring direction relative to inertial space, and is therefore a possible competitor to the gyroscope for inertial navigation. The ring laser can also measure the velocity of a transparent medium moving relative to it, which could be of use in determining vehicle velocity.
Lithium Ion Conductivity in a Perovskite Lanthanum Lithium Titanate Single Crystal (1997)

A perovskite La0.59±0.01Li0.27±0.01TiO3.02±0.02 single crystal was grown by the floating zone method and its lithium ion conductivity was measured. The conductivity was found to be predominantly ionic. The ionic conductivities at 300K parallel and perpendicular to the c-axis are 5.8×10-4 and 6.8×10-4S·cm-1, respectively. The anisotropy of the ionic conductivity corresponds to that of the structure, i.e., of the distribution of La ions. Furthermore, the ionic conductivity and activation energy for ion conduction are almost the same as those of a grain in polycrystalline samples, indicating that the evaluation of the ionic conductivity of polycrystalline samples was appropriate.
Extending Maple to the Grid: Design and Implementation (2005)

One of the important issues facing the development of the grid as the computational framework of the future is availability of grid-enabled software. In this context, we discuss possible approaches to constructing a grid-enabled version of a computer algebra system. Our case study involves Maple: the proposed Maple2g package allows the connection between Maple and the computational grids based on the Globus Toolkit. We present the design of the Maple2g package and follow with a thorough discussion of its implementation.