gebhart/patrepeval huggingface dataset:
Method to generate 112 Gbit/s polarisation-multiplexed 8QAM signal (2012)

Proposed is a new method to synthesise the 8-ary quadrature amplitude modulation (8QAM) signal and demonstrate the 112 Gbit/s polarisation-multiplexed 8QAM system. The proposed transmitter consists of a dual-drive Mach-Zehnder modulator (DD-MZM) and phase modulators in tandem. The DD-MZM is utilised to manipulate the amplitude and phase of the optical signal by adjusting its chirp. The optical signal-to-noise ratio sensitivity of the 112 Gbit/s polarisation-multiplexed 8QAM signal to achieve the bit error rate of 10−3 is measured to be 18.8 dB (in 0.1 nm resolution bandwidth).
<b>2-Phenyl-2,1-borazarene and Derivatives of 1,2-Azaboracycloalkanes</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Phenyl-2,1-borazarene and Derivatives of 1,2-AzaboracycloalkanesDavid G. WhiteCite this: J. Am. Chem. Soc. 1963, 85, 22, 3634–3636Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/ja00905a022https://doi.org/10.1021/ja00905a022research-articleACS PublicationsRequest reuse permissionsArticle Views629Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dual regulation of mucoidy in <i>Pseudomonas aeruginosa</i> and sigma factor antagonism (2000)

The conversion to mucoid, exopolysaccharide alginate-overproducing phenotype in Pseudomonas aeruginosa during chronic respiratory infections in cystic fibrosis patients occurs via mutations that activate the alternative sigma factor AlgU (sigmaE). In this study, we demonstrate that conversion to mucoidy can be caused via a second, algU-independent pathway, in which alginate production and transcription of the critical algD promoter depend on another alternative sigma factor, RpoN (sigma54). The algD promoters dependent on sigma54 and sigmaE showed a complete overlap resulting in identical mRNA 5' ends. The two pathways were not independent, as sigma54 also repressed sigmaE-dependent transcription of algD both in vitro and in vivo. The negative regulatory effect of sigma54 on sigmaE-dependent algD expression was based on sigma54 binding to the algD promoter and its interference with sigmaE-dependent transcription. This phenomenon, referred to here as sigma factor antagonism, reflects the unique properties of sigma54, which lacks an intrinsic ability to form open transcription initiation complexes. We propose that this peculiar feature of sigma54 has evolved in part to allow its recruitment as a repressor of certain promoter subsets. The repression of algD by sigma54 also depends on environmental conditions, supporting the notion that sigma factor antagonism plays a physiological role in controlling alginate production in P. aeruginosa during adaptation to different ecological sites (e.g. biofilm development, stress and other growth conditions) and unique environments in the chronically infected host.
Extremely Facile Oxidative Addition of Silyl, Germyl, and Stannyl Tellurides and Other Chalcogenides to Platinum(0) Complexes. X-ray Structure of <i>trans</i>-Pt(4-PhC<sub>6</sub>H<sub>4</sub>Te)(SiMe<sub>3</sub>)(PEt<sub>3</sub>)<sub>2</sub> (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTExtremely Facile Oxidative Addition of Silyl, Germyl, and Stannyl Tellurides and Other Chalcogenides to Platinum(0) Complexes. X-ray Structure of trans-Pt(4-PhC6H4Te)(SiMe3)(PEt3)2Li-Biao Han, Shigeru Shimada, and Masato TanakaView Author Information National Institute of Materials and Chemical Research Tsukuba, Ibaraki 305, Japan Cite this: J. Am. Chem. Soc. 1997, 119, 34, 8133–8134Publication Date (Web):August 27, 1997Publication History Received30 April 1997Published online27 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja9713744https://doi.org/10.1021/ja9713744rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views405Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Equilibrium,Nuclear magnetic resonance spectroscopy,Organic reactions,Oxidative addition,Platinum Get e-Alerts
A Heuristic Approach for Selection of Software Architecture Using Functional Key Areas and Visualization Tools Integrated with DArch (2009)

Architecting the distributed software applications is a complex design activity. The selection of a best design among number of design alternatives is an important activity. To satisfy various stakeholders ’ functional and non-functional requirements of a particular application, there is a need to take a number of decisions. This problem has become the multiple decision making problem. Visualization tools based on functional key areas integrated with DArch have been used in the context. In this paper we are proposing a new approach for selection of Software Architectures using functional key areas which are basis for visualization tools. Key words: Heuristic, DArch. 1.
A case of colonic tuberculosis mimicking Crohn's disease. (1998)

A 26-year-old Thai woman who has lived in Hong Kong for the past 3 years presented with a 2-month history of feverishness, intermittent epigastric discomfort, anorexia, and weight loss. She had had per rectal bleeding for 10 days. Colonoscopy on two separate occasions revealed multiple ulcerations involving the entire colon, with rectal sparing. Histological examination of the two sets of colonic biopsies that were obtained during colonoscopy suggested Crohn's disease. There was no response to mesalazine and metronidazole, but the patient responded promptly to a therapeutic trial of antituberculous drugs. Cultures from the first set of colonic biopsies were negative for acid-fast bacilli, but 8 weeks after the second colonoscopy, cultures from the second set of biopsies yielded Mycobacterium tuberculosis. This case illustrates that the diagnosis of colonic tuberculosis requires a high index of suspicion. In cases where the information available does not reveal a definite differentiation between colonic tuberculosis and Crohn's disease, corticosteroids should be withheld. The administration of corticosteroids to a patient with colonic tuberculosis may have disastrous results, and a therapeutic trial of antituberculous drugs should be considered instead.
A Soluble Form of the <i>Tomato spotted wilt virus</i> (TSWV) Glycoprotein G<sub>N</sub> (G<sub>N</sub>-S) Inhibits Transmission of TSWV by <i>Frankliniella occidentalis</i> (2007)

Tomato spotted wilt virus (TSWV) is an economically important virus that is transmitted in a persistent propagative manner by its thrips vector, Frankliniella occidentalis. Previously, we found that a soluble form of the envelope glycoprotein G(N) (G(N)-S) specifically bound thrips midguts and reduced the amount of detectable virus inside midgut tissues. The aim of this research was to (i) determine if G(N)-S alters TSWV transmission by thrips and, if so, (ii) determine the duration of this effect. In one study, insects were given an acquisition access period (AAP) with G(N)-S mixed with purified virus and individual insects were assayed for transmission. We found that G(N)-S reduced the percent of transmitting adults by eightfold. In a second study, thrips were given an AAP on G(N)-S protein and then placed on TSWV-infected plant material. Individual insects were assayed for transmission over three time intervals of 2 to 3, 4 to 5, and 6 to 7 days post-adult eclosion. We observed a significant reduction in virus transmission that persisted to the same degree throughout the time course. Real-time reverse transcription polymerase chain reaction analysis of virus titer in individual insects revealed that the proportion of thrips infected with virus was reduced threefold when insects were preexposed to the G(N)-S protein as compared to no exposure to protein, and nontransmitters were not infected with virus. These results demonstrate that thrips transmission of a tospovirus can be reduced by exogenous viral glycoprotein.
The role of voice input for human-machine communication. (1995)

Optimism is growing that the near future will witness rapid growth in human-computer interaction using voice. System prototypes have recently been built that demonstrate speaker-independent real-time speech recognition, and understanding of naturally spoken utterances with vocabularies of 1000 to 2000 words, and larger. Already, computer manufacturers are building speech recognition subsystems into their new product lines. However, before this technology can be broadly useful, a substantial knowledge base is needed about human spoken language and performance during computer-based spoken interaction. This paper reviews application areas in which spoken interaction can play a significant role, assesses potential benefits of spoken interaction with machines, and compares voice with other modalities of human-computer interaction. It also discusses information that will be needed to build a firm empirical foundation for the design of future spoken and multimodal interfaces. Finally, it argues for a more systematic and scientific approach to investigating spoken input and performance with future language technology.
Short-term and long-term evaluation of selective serotonin reuptake inhibitors in the treatment of panic disorder: fluoxetine vs citalopram (1999)

This double-blind study evaluates the efficacy and tolerability of fluoxetine and citalopram in the acute and long-term treatment of panic disorder in 42 patients meeting DSM-IV criteria for panic disorder with or without agoraphobia. Fluoxetine and citalopram showed similar efficacy in the treatment of panic disorder patients. On the basis of HRSA and PASS mean score evaluation, fluoxetine was more rapid than citalopram in reducing generalized anxiety symptoms, spontaneous panic attacks and anticipatory anxiety. Fluoxetine appeared to be effective at a dosage of 10 mg/day, while citalopram reached the same efficacy at a dosage of 30 mg/day. Long-term evaluation has demonstrated high rates of persistent full remission with both drugs. Copyright © 1999 John Wiley & Sons, Ltd.
All-optical logic xor gate at 80 gb/s using SOA-MZI-DI (2006)

All-optical xor operation has been demonstrated using a semiconductor optical amplifier Mach-Zehnder interferometer (SOA-MZI) and delayed interferometer (DI) at 80 Gb/s. The DI is based on a polarization maintaining loop (PML) mirror. The results show using the PML-DI in series with the SOA-MZI improves the pulse quality of the xor result.
Virtual Remote Center of Motion control for needle placement robots (2004)

This research enables robotic assistant systems for image-guided percutaneous procedures to be prototyped/constructed more quickly and less expensively than has been previously possible. Since the clinical utility of such systems is clear and has been demonstrated in the literature, our work may help promote widespread clinical adoption of this technology by lowering system cost and complexity.
The penultimate tyrosine residue of the K99 fibrillar subunit is essential for stability of the protein and its interaction with the periplasmic carrier protein (1990)

The role of the penultimate and conserved tyrosine residue of the K99 major fibrillar subunit (FanC) in fibrillae biosynthesis and functioning was investigated. By using oligonucleotide-directed in vitro mutagenesis the TAT codon of tyrosine-158 of fanC was changed into a TAG stop codon. The mutant fanC gene encoded a truncated major subunit lacking the two carboxyl-terminal amino acid residues. Furthermore, the tyrosine residue (position 158) was replaced by a serine residue or by a glutamic acid residue. The effect of these mutations on the expression and binding capacity of K99 fibrillae was investigated by using an ELISA, an haemagglutination assay, Escherichia coli minicells and suppressor strains. All mutations completely blocked K99 fibrillae biosynthesis and haemagglutination activity. The mature form of the truncated mutant FacC polypeptide could not be detected in minicells, but its precursor was expressed at a normal level. The results showed that the penultimate tyrosine residue is essential for the expression of mature fibrillar subunits and suggested a function in the interaction with the periplasmic transport protein FanE.
Toward privacy-assured and searchable cloud data storage services (2013)

Cloud computing is envisioned as the next generation architecture of IT enterprises, providing convenient remote access to massively scalable data storage and application services. While this outsourced storage and computing paradigm can potentially bring great economical savings for data owners and users, its benefits may not be fully realized due to wide concerns of data owners that their private data may be involuntarily exposed or handled by cloud providers. Although end-to-end encryption techniques have been proposed as promising solutions for secure cloud data storage, a primary challenge toward building a full-fledged cloud data service remains: how to effectively support flexible data utilization services such as search over the data in a privacy-preserving manner. In this article, we identify the system requirements and challenges toward achieving privacy-assured searchable outsourced cloud data services, especially, how to design usable and practically efficient search schemes for encrypted cloud storage. We present a general methodology for this using searchable encryption techniques, which allows encrypted data to be searched by users without leaking information about the data itself and users¿ queries. In particular, we discuss three desirable functionalities of usable search operations: supporting result ranking, similarity search, and search over structured data. For each of them, we describe approaches to design efficient privacy-assured searchable encryption schemes, which are based on several recent symmetric-key encryption primitives. We analyze their advantages and limitations, and outline the future challenges that need to be solved to make such secure searchable cloud data service a reality.
Intermediate Phases in Some Rare Earth - Rhodium Systems (1973)

The phase equilibria and crystal structures of intermediate phases were investigated in eight representative RE-Ru systems using powder X-ray diffraction and metallographic techniques. The Fe3C, Mn5C2 and Er5Ru3 structures occur in all but the Ce-Ru systems. Phases analogous to Er5Ru3 possess an unknown crystal structure similar to Er5Rh3(I). MgCu2 and MgZn2 type Laves phases are encountered in the light rare earth and heavy rare earth systems, respectively, and RERu2 phases, where RE = Nd and Sm, possess both the Laves phase structures. An intermediate phase, NdRu, with an unknown structure, occurs only in the Nd-Ru system. A bcc structure with 40 atoms per unit cell is encountered in the phases Er3Ru2 and Y3Ru2. The behavior of cerium in Ce-Ru alloys is unique in that four unidentified structures, not encountered in other RE-Ru systems, have been encountered. Also a phase designated as Ce3Ru is found with the Th7Fe3 type structure.
Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors (2011)

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors. These proteins direct gene expression in diverse normal and disease states by binding to specific promoters and enhancers and facilitating assembly of other components of the transcriptional machinery. The highly conserved DNA-binding ETS domain defines the family and is responsible for specific recognition of a common sequence motif, 5'-GGA(A/T)-3'. Attaining specificity for biological regulation in such a family is thus a conundrum. We present the current knowledge of routes to functional diversity and DNA binding specificity, including divergent properties of the conserved ETS and PNT domains, the involvement of flanking structured and unstructured regions appended to these dynamic domains, posttranslational modifications, and protein partnerships with other DNA-binding proteins and coregulators. The review emphasizes recent advances from biochemical and biophysical approaches, as well as insights from genomic studies that detect ETS-factor occupancy in living cells.
Duurzame ontwikkeling. Mode of maatstaf? (1997)

In 1996 startten het Universitair Milieu Platform UMP-Utrecht en het Bureau Studium Generale samen een project rond duurzame ontwikkeling. Het project omvat vier onderdelen en begon in februari en maart 1996 met een algemeen lezingenprogramma over het begrip duurzame ontwikkeling. In deze bundel zijn de teksten van dit lezingenprogramma verzameld.\nDuurzame ontwikkeling is in meerdere opzichten een dubbel begrip. Niet alleen bestaat het uit twee woorden die elkaar soms lijken uit te sluiten, ook de consensus over het begrip heeft twee niveaus. Als het gaat om de definitie in het zogenaamde Brundtlandrapport - 'een ontwikkeling die voorziet in de behoeften van de huidige generatie, zonder de mogelijkheden van toekomstige generaties aan te tasten om in hùn behoeften te voorzien' - knikt iedereen instemmend mee. Niet voor niets werden zo'n 170 landen het in Rio de Janeiro eens over de noodzaak van duurzame ontwikkeling. Het begrip werd wereldberoemd en begon als een soort modeverschijnsel te pas en te onpas op te duiken. Vaak werd echter ook op de consequenties van het begrip duurzame ontwikkeling gewezen. Bijvoorbeeld de consequenties voor de Nederlandse productie- en consumptiepatronen. En dan is de consensus plotseling veel minder groot. Is het wel mogelijk om het begrip duurzame ontwikkeling inderdaad als maatstaf voor het handelen te gebruiken? Deze vraag stond centraal in het lezingenprogramma, dat daarom de naam Duurzame ontwikkeling: mode of maatstaf? kreeg.
ET-31 * RADIOSENSITIZATION BY OMX-4.80P, A PEGylated H-NOX OXYGEN CARRIER THAT PENETRATES AND OXYGENATES HYPOXIC TUMORS, IN PRECLINICAL MODELS OF GLIOBLASTOMA AND OTHER HYPOXIC CANCERS (2014)

BACKGROUND: Omniox has engineered OMX-4.80P, a PEGylated H-NOX oxygen carrier, as a long-acting therapeutic candidate to enhance radiotherapy (RT) in the treatment of glioblastoma (GB) and other solid tumors. We have previously described the un-PEGylated OMX-4.80 variant, which can penetrate intracranial mouse GB tumors, release oxygen exclusively into hypoxic tumor tissue, and enhance tumor growth delay and survival when combined with RT. However, OMX-4.80 has a short circulation half-life that limits its clinical potential. Here, we describe the pre-clinical profile of PEGylated OMX-4.80 (OMX-4.80P), demonstrating it is well tolerated, long-lasting in circulation and tumors, and is significantly more efficacious than OMX-4.80. METHODS: We PEGylated OMX-4.80 to increase its circulation half-life while retaining its ability to preferentially accumulate in tumors and selectively release oxygen to hypoxic microenvironments. We characterized the efficacy of OMX-4.80P in large, hypoxic, radioresistant tumors, and its activity in intracranial GB models in nude mice and immunocompetent rats. We also conducted toxicology and pharmacokinetic studies in multiple animal models including naïve dogs. RESULTS: In xenograft studies of large, hypoxic, radioresistant tumors, single doses of OMX-4.80P in combination with RT result in apparent tumor cures in ∼30-50% of tumors compared to 0% cures in RT-only groups. Interestingly, the larger molecular size of OMX-4.80P (∼120kDa) did not prevent its passing the blood-tumor barrier in mouse and rat intracranial tumors and resulted in hypoxia reduction. Pharmacokinetic and toxicology studies using single or multiple supratherapeutic and therapeutic doses of OMX-4.80P in rodents and dogs demonstrated that it has a circulation half-life of ∼24h in rats and ∼52h in dogs, compared to 1-2h for OMX-4.80, and that it is well tolerated. Finally, OMX-4.80P has no detectable immunogenic response. CONCLUSIONS: The preclinical efficacy data, and promising pharmacokinetic and toxicology profile, of OMX-4.80P support its clinical development for the enhancement of radiotherapy in GB patients.
Synthesis of maleic anhydride grafted polyethylene and polypropylene, with controlled molecular structures (2000)

This article discusses a new chemical route to prepare maleic anhydride (MA) grafted polyethylene and polypropylene polymers with controlled molecular structure, that is, MA grafted content and polymer molecular weight and composition distributions. The chemistry involves a free radical graft reaction of maleic anhydride with poly(ethylene-co-p-methylstyrene) and poly(propylene-co-p-methylstyrene) copolymers. Under a suspension reaction condition, the grafting reaction takes place selectively on the p-methylstyrene units in the copolymer, due to high reactivity of p-methyl group and favorable mixing between p-methylstyrene units and chemical reagents in the swollen amorphous phases. The resulting polymer shows no detectable molecular weight change during the reaction, and the MA grafted content increases with the increase of initiator and p-methylstyrene concentrations. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 1337–1343, 2000