gebhart/patrepeval huggingface dataset:
Human standing balance is affected by exposure to pulsed ELF magnetic fields: light intensity-dependent effects (2001)

There is evidence in animals that behavioral and physiological responses to static and extremely low frequency magnetic fields (ELFMF) is affected by the presence of light during magnetic field exposures. Here we report that the effect of a specific pulsed ELFMF (PEMF) on human standing balance is modulated by light intensity during exposure. Under a low light condition (0.12 W/m2), nine healthy human volunteers stood on a 3D forceplate, throughout four 2 min exposures (eyes open/eyes close, sham/PEMF of 200 +/- 1 microTpk, order randomized). There was a significant increase in standing movement during PEMF exposure during eyes closed. In a second experiment on 26 normal subjects exposed to the identical protocol, but at greater light intensities (0.51 W/m2), a significant but opposite effect was observed.
Interleukin‐1β up‐regulates expression of neurofilament light in human neuronal cells (2001)

Elevated expression of interleukin-1 (IL-1beta), a pro-inflammatory cytokine secreted by activated microglia, is a pathogenic marker of numerous neurodegenerative processes including Alzheimer's disease (AD). We have characterized a link between IL-1beta and the 68-kDa neurofilament light (NF-L) protein, which is a major component of the neuronal cytoskeleton. Using human brain aggregate cultures, we found that IL-1beta treatment significantly increased NF-L expression in primary neurons. Analysis of mRNA levels demonstrated elevated NF-L expression within 72 h while imaging of neurons by immunofluorescent staining for NF-L confirmed IL-1beta-induced NF-L protein expression. These observations suggest a potential inflammatory-induced mechanism for deregulation of an important cytoskeletal protein, NF-L, possibly leading to neuronal dysfunction.
Modification of Heat Coagulated Whey Protein Concentrates by Succinylation (1980)

Heat coagulated cheese whey protein concentrate was modified by reaction with succinic anhydride at pH 8 followed by isoelectric precipitation, neutralization, and freeze drying. All functional properties except whippability were improved. Succinylated whey protein concentrate dispersed readily as highly swollen particles with high viscosity. It can absorb 11 to 13 times and 2 to 3 times its weight of water and fat. It has high emulsifying capacity and can form stable emulsions at 1% usage. Gel filtration indicates extensive unfolding of the protein after succinylation. Except for a slight decrease in lysine, the amino acid composition was unaltered. Succinylation increased the protein content of the whey protein concentrate with little loss in biological value and yield. Possible application of the succinylated product would be in products which require high water and fat absorption capacities, viscosity, and emulsifying properties such as baked goods, processed meats, and dairy analogs.
Preparation of poly(styrene‐<i>co</i>‐isobornyl methacrylate) beads having controlled glass transition temperature by suspension polymerization (2012)

Abstract The styrene (St) and isobornyl methacrylate (IBMA) random copolymer beads with controlled glass transition temperature ( T g ), in the range of 105–158°C, were successfully prepared by suspension polymerization. The influence of the ratios of IBMA in monomer feeds on the copolymerization yields, the molecular weights and molecular weight distributions of the produced copolymers, the copolymer compositions and the T g s of these copolymers was investigated systematically. The monomer reactivity ratios were r 1 (St) = 0.57 and r 2 (IBMA) = 0.20 with benzyl peroxide as initiator at 90°C, respectively. As the mass fraction of IBMA in monomer feeds was about 40 wt %, it was observed that the monomer conversion could be up to 90 wt %. The fractions of IBMA unit in copolymers were in the range of 35–40 wt % and T g s of the corresponding copolymers were in the range of 119.6–128°C while the monomer conversion increased from 0 to greater than 90 wt %. In addition, the effects of other factors, such as the dispersants, polymerization time and the initiator concentration on the copolymerization were also discussed. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Modification of formants in the line spectrum domain (2002)

A method for modifying formant locations and bandwidths directly in the line spectrum domain is developed. This method is based on first-order approximations between different representations of the linear prediction spectrum and does not require finding the roots of the prediction polynomial. In addition, this method is less sensitive to pole interaction problems associated with direct pole modification.
The American Poverty Programme 1969–71 (1974)

Studies of the American ‘War on Poverty’ have concentrated on the period 1964–8 during which it attracted much attention due, firstly, to its optimistic claims to abolish poverty and, secondly, to the militant tactics used by some of its participants. Little note has been given to the years 1969–71, yet during this period significant changes occurred. In the Spring term of 1972 I was able to visit a number of the programme's projects and to study at the headquarters of the Office of Economic Opportunity. Having had access to documents with a limited circulation I am thus able to describe developments in the later period in a way which, to my knowledge, has not been published previously in Britain.
Protein S, an Antithrombotic Factor, Is Synthesized and Released by Neural Tumor Cells (1993)

Protein S, an anticoagulant factor in the protein C antithrombotic pathway, was found to be synthesized and released by six tumor cell lines of neural origin by western blotting and ELISA. The rate of synthesis ranged from three- to 11-fold higher than that of a microvascular endothelial cell line and 36-144% that of a hepatoma cell line. The secreted protein S displayed specific anticoagulant activity similar to that of purified plasma protein S, implying that it was fully gamma-carboxylated. Ten primary brain tumor tissues also expressed protein S antigen, as shown by western blot analysis. Expression of anticoagulantly active protein S by neural cells raises important questions concerning possible physiologic roles for this multidomain protein beyond its function in control of thrombosis.
Use of Fat Replacers in Low Fat Mozzarella Cheese (1996)

Low fat Mozzarella cheeses with <6% fat were made using fat replacers to increase the moisture content and to improve the functional properties of the cheese. We used two protein-based fat replacers (Simplesse@ DlOO and Dairy-Lo@) and two carbohydrate-based fat replacers (Stellar'" 1OOX and Novagel'" . Moisture contents of the cheeses were 53.0, 54.3, 55.2, 55.3, and 57.3% for the control, Stellar'", Dairy-Lo@, Simplesse@, and Novagel'" cheeses, respectively. Apparent viscosity of the cheese at 80C was not significantly affected by addition of fat replacers, but there was a significant effect on meltability. Cheeses made with Stellar'" and Simplesse@ had greater overall meltability than cheese made with Dairy-Lo@ or the control. The cheese made with Novagel'" contained the most moisture but, from d 1 to dl 14, melted to the least extent. By d 21, all cheeses melted to the same extent.
FLEXIBLE WING RESEARCH AND DEVELOPMENT (1963)

Flexible wings red - stability & control of para- gliders as decelerators for spacecraft recovery
Structure preserving direct methods for transient stability analysis of power systems (1985)

A structure preserving network configuration is considered, along with many realistic types of active and reactive load models. A unified approach is developed and general energy Liapunov functions are accordingly constructed. Practical stability domains and their use for devising appropriate direct criteria are proposed. Implementation considerations are discussed and illustrated.
Application of Silicon Photomultipliers to Positron Emission Tomography (2011)

Historically, positron emission tomography (PET) systems have been based on scintillation crystals coupled to photomultipliers tubes (PMTs). However, the limited quantum efficiency, bulkiness, and relatively high cost per unit surface area of PMTs, along with the growth of new applications for PET, offers opportunities for other photodetectors. Among these, small-animal scanners, hybrid PET/MRI systems, and incorporation of time-of-flight information are of particular interest and require low-cost, compact, fast, and magnetic field compatible photodetectors. With high quantum efficiency and compact structure, avalanche photodiodes (APDs) overcome several of the drawbacks of PMTs, but this is offset by degraded signal-to-noise and timing properties. Silicon photomultipliers (SiPMs) offer an alternative solution, combining many of the advantages of PMTs and APDs. They have high gain, excellent timing properties and are insensitive to magnetic fields. At the present time, SiPM technology is rapidly developing and therefore an investigation into optimal design and operating conditions is underway together with detailed characterization of SiPM-based PET detectors. Published data are extremely promising and show good energy and timing resolution, as well as the ability to decode small scintillator arrays. SiPMs clearly have the potential to be the photodetector of choice for some, or even perhaps most, PET systems.
A Multistage Model of Bargaining (1983)

This paper presents a simple, multistage model of bargaining wherein a seller makes an offer that can be either accepted or refused.If rejected, the process continues.How the seller's ability to make commitments affects bargaining outcomes is analysed by comparing the commitment equilibria to those arising when commitment is impossible.The effects of increasing uncertainty about preferences and varying the length of the bargaining horizon are analysed.The ways in which the bargaining environment can be changed to improve outcomes are discussed.
Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in <i>CRLF2</i> rearranged and/or <i>JAK</i> driven Philadelphia chromosome-like acute B-cell lymphoblastic leukemia (2018)

Patients with cytokine receptor-like factor 2 rearranged (<i>CRLF2</i>-re) subgroup Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like B-ALL) have a high relapse rate and poor clinical outcomes. <i>CRFL2</i>-re Ph-like B-ALL is characterized by heightened activation of multiple signaling pathways, including the JAK/STAT and PI3K/AKT/mTOR pathways. We hypothesized that the combined inhibition by JAK2 and mTOR inhibitors would induce an additive antileukemia effect in <i>CRLF2</i>-re Ph-like B-ALL. In this study, we tested the antileukemia efficacy of the type I JAK inhibitor ruxolitinib and type II JAK inhibitor NVP-BBT594 (hereafter abbreviated BBT594) [1] alone and combined with allosteric mTOR inhibitor rapamycin and a second generation ATP-competitive mTOR kinase inhibitor AZD2014. We found that BBT594/AZD2014 combination produced robust anti-leukemic effects in Ph-like cell lines <i>in vitro</i> and in patient-derived xenograft (PDX) cells cultured <i>ex vivo</i>. JAK2/mTOR inhibition arrested the cell cycle and reduced cell survival to a greater extent in Ph-like B-ALL cells with <i>CRLF2</i>-re and <i>JAK2</i> mutation. Synergistic cell killing was associated with the greater inhibition of JAK2 phosphorylation by BBT594 than by ruxolitinib and the greater inhibition of AKT and 4E-BP1 phosphorylation by AZD2014 than by rapamycin. <i>In vivo</i>, BBT594/AZD2014 co-treatment was most efficacious in reducing spleen size in three Ph-like PDX models, and markedly depleted bone marrow and spleen ALL cells in an <i>ATF7IP-JAK2</i> fusion PDX. In summary, combined inhibition of JAK/STAT and mTOR pathways by next-generation inhibitors had promising antileukemia efficacy in preclinical models of <i>CRFL2-</i>re Ph-like B-ALL.
Interface modifications in solid state dye-sensitized TiO 2 solar cells (2004)

The concept of solid-state dye-sensitized TiO<sub>2</sub> solar cell in which the hole transport medium is an organic semiconductor is critically studied by examining the anode-TiO<sub>2</sub> interface and dye-hole conductor interface. The importance and the role of a compact hole-blocking TiO<sub>2</sub> layer in between the anode and the mesoporous layer is extensively studied by preparing this layer by spray pyrolysis using an automated procedure which guarantees reproducibility in obtaining constant thickness and quality of this crucial layer as seen in the current-voltage characteristics of the solar cells. To characterize the rectifying behavior of the blocking layer, cells with the structure, fluorinated tin oxide (FTO)/blocking TiO<sub>2</sub> layer/hole conductor/Au, were prepared and their current (I)-voltage (U) properties were investigated. Solid state solar cells were also prepared with different blocking layer thicknesses and their photovoltaic properties were investigated in order to study the influence of the blocking layer thickness on solar cell performance. In order to improve the dye-hole conductor interface, novel multifunctional molecules carrying dye units and triphenylamine moieties were synthesized and their influence as interface modifiers were studied. This interface modification results in doubling the external quantum efficiency of current conversion via improved charge transfer at the dye-hole conductor interface. Moreover, the recombination processes at this interface is drastically suppressed which leads to higher open circuit voltage and consequently higher power conversion efficiencies.
Measurement by a Novel LC-MS/MS Methodology Reveals Similar Serum Concentrations of Vitamin D–Binding Protein in Blacks and Whites (2015)

Validated mass spectrometric methods for the quantification of proteins in human samples can provide additional information beyond immunoassay. Counter to prior observations by immunoassay, VDBG concentrations did not vary by race.
‘Squirrel Cage’ Electrical Motors (1988)

This chapter is an account of research carried out on the quality levels of 3-phase Asynchronous AC Induction Motors, having rotors of a 'squirrel cage' construction. These products were selected for study because the present authors considered it to be important to assess the quality of Soviet design and manufacture in the field of electrical technology. Electrical motors are typical examples of products using widely-diffused and standardised electro-mechanical technologies, and squirrel cage motors in their turn are the most widely used type of electrical motor in industry.1KeywordsElectrical MotorMotor TypeAsynchronous MotorFree OperationMean Time Between FailureThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Infrared spectroscopy of human tissue. I. Differentiation and maturation of epithelial cells in the human cervix (1998)

Infrared spectral results for the different epithelial layers of human cervical squamous tissue are reported. The layers, representing different cellular maturation stages, exhibit quite different spectral patterns. Thus, infrared spectroscopy presents a powerful tool to monitor cell maturation and differentiation. Furthermore, a detailed understanding of the spectra of the individual layers of tissue permit a proper interpretation of the state of health of cells exfoliated from such tissue. Part II of this series describes the use of the spectral information presented here to interpret the infrared spectra of exfoliated cells. © 1998 John Wiley & Sons, Inc. Biospectroscopy 4: 47–53, 1998
Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase (2012)

Lesch-Nyhan disease (LND) is an X-linked genetic disorder caused by mutations of the hypoxanthine guanine phosphoribosyltransferase (HPRT) purine biosynthesis gene and characterized by aberrant purine metabolism, deficient basal ganglia dopamine levels, dystonia, and severe neurobehavioral manifestations, including compulsive self-injurious behavior. Although available evidence has identified important roles for purinergic signaling in brain development, the mechanisms linking HPRT deficiency, purinergic pathways, and neural dysfunction of LND are poorly understood. In these studies aimed at characterizing purinergic signaling in HPRT deficiency, we used a lentivirus vector stably expressing an shRNA targeted to the HPRT gene to produce HPRT-deficient human CVB induced pluripotent stem cells and human HUES11 embryonic stem cells. Both CVB and HUES11 cells show >99% HPRT knockdown and demonstrate markedly decreased expression of the purinergic P2Y1 receptor mRNA. In CVB cells, P2Y1 mRNA and protein down-regulation by HPRT knockdown is refractory to activation by the P2Y1 receptor agonist ATP and shows aberrant purinergic signaling, as reflected by marked deficiency of the transcription factor pCREB and constitutive activation of the MAP kinases phospho-ERK1/2. Moreover, HPRT-knockdown CVB cells also demonstrate marked reduction of phosphorylated β-catenin. These results indicate that the housekeeping gene HPRT regulates purinergic signaling in pluripotent human stem cells, and that this regulation occurs at least partly through aberrant P2Y1-mediated expression and signaling. We propose that such mechanisms may play a role in the neuropathology of HPRT-deficiency LND and may point to potential molecular targets for modulation of this intractable neurological phenotype.
Backstepping design with local optimality matching (2001)

In this study of the nonlinear HI-optimal control design for strict-feedback nonlinear systems, our objective is to construct globally stabilizing control laws to match the optimal control law up to any desired order, and to be inverse optimal with respect to some computable cost functional. Our recursive construction of a cost functional and the corresponding solution to the Hamilton-Jacobi-Isaacs equation employs a new concept of nonlinear Cholesky factorization. When the value function for the system has a nonlinear Cholesky factorization, we show that the backstepping design procedure can be tuned to yield the optimal control law.
Mössbauer Effect in Chemistry and Solid-State Physics (1964)

The use of Mossbauer effect in chemistry and solidstate physics is reviewed. Detection of recoil-free gamma rays, atomic motion, the isomer shift, electric hyperfine splitting, and magnetic hyperfine splitting are discussed. 60 references are included. (P.C.H.)
Automatisierte Inbetriebnahme von Industriellen IoT-Systemen in der Prozessautomatisierung: Eine Referenzarchitektur (2019)

Zusammenfassung Die Inbetriebnahme von Prozessleitsystemen ist heutzutage teuer und umständlich, da ein hoher manueller Aufwand nötig ist. Durch den Trend zu Industrie 4.0 und IIoT sind bereits eine Vielzahl industrieller Standards verfügbar, auf deren Basis herstellerunabhängige selbstkonfigurierende Geräte („Plug-and-Produce“ (PnP)) realisiert werden können, die den Aufwand der Inbetriebnahme verringern. In diesem Papier stellen wir eine auf solchen Standards basierende Referenzarchitektur für IIoT-Prozessautomatisierungssysteme vor. Die Eckpfeiler der Architektur sind (i) die Verwendung modellbasierter Beschreibungen basierend auf PLCopen für gesteuerte Geräte, (ii) die Spezifikation eines PnP-Dienstes, der das Abstimmen der Konfigurationen von Steuereinheit (engl. Controller) und Feldgeräten entkoppelt und hierzu auf OPC UA Pub/Sub zurückgreift sowie (iii) die Verwendung von Technologien für selbstkonfigurierende Netzwerke. Weiterhin diskutieren wir zukünftige Forschungsherausforderungen, die auf der vorgeschlagenen Architektur aufbauen.
Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma (2008)

The purpose of this study is to estimate the maximum-tolerated dose (MTD) and describe toxicities and preliminary clinical effects of tipifarnib, a farnesyltransferase (FTase) inhibitor, administered concurrently with radiation therapy in children with newly diagnosed intrinsic diffuse brainstem glioma (BSG). Children >or=3 and <or=21 years of age with newly diagnosed nondisseminated intrinsic diffuse BSG were treated with concurrent tipifarnib and radiation, followed by adjuvant tipifarnib. Escalating doses of tipifarnib were administered orally twice daily, continuously, for the entire duration of radiation, followed by a 2-week break. Postradiation tipifarnib, 200 mg/m(2)/dose, was administered twice daily for 21 consecutive days, in 28-day cycles. Seventeen patients, median age 5.9 years (range, 3.6-13.8), received external beam radiation therapy administered concurrently with tipifarnib at dose levels ranging from 100 to 150 mg/m(2)/dose, followed by adjuvant tipifarnib for up to 24 months in the absence of tumor progression or unacceptable toxicity. Dose-limiting toxicities were grade 3 skin rash in one patient at the 125 mg/m(2) dose level and two patients at the 150 mg/m(2) dose level, and grade 3 pneumonia with a normal absolute neutrophil count (ANC) in one patient at the 150 mg/m(2) dose level. One patient had isolated grade 4 neutropenia at the 150 mg/m(2) dose level. The MTD of tipifarnib administered was estimated as 125 mg/m(2)/dose b.i.d. When administered concurrently with radiation, the dose-limiting toxicities of tipifarnib are rash, infection with normal ANC, and neutropenia. The MTD of tipifarnib with concurrent radiation is 125 mg/m(2)/dose b.i.d. One-year survival and progression-free survival estimates are 36.4% (SE 16.7%) and 9.4% (SE 6.3%), respectively.
Another Face of Planning: Human Service Planning in Direct-Service Agencies (1984)

Interviews with people engaged in planning in direct-service agencies reveal considerable differences from more con ventional planners, as portrayed in the literature They are less likely to be tech nicians and more likely to consider the political aspects of planning important, they are involved in decision making and implementation as well as planning, and nearly all of them claim to be satisfied with their planning work. Their exper iences may provide valuable lessons for more coventional planners, but their single-agency focus and limited technical abilities represent problems that must also be recognized For human service plan ning, advocating greater political sensi tivity and skill may be less useful than showing how political and technical skills can be combined in equal proportions.
Rapid determination of zinc and other impurities in cadmium (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid determination of zinc and other impurities in cadmiumH. G. IsbellCite this: Ind. Eng. Chem. Anal. Ed. 1932, 4, 3, 284–286Publication Date (Print):July 1, 1932Publication History Published online1 May 2002Published inissue 1 July 1932https://doi.org/10.1021/ac50079a017RIGHTS & PERMISSIONSArticle Views53Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (450 KB) Get e-Alerts