gebhart/patrepeval huggingface dataset:
Morphological transformation during cross-linking of a highly sulfonated poly(phenylene sulfide nitrile) random copolymer (2012)

We present a new approach of morphological transformation for effective proton transport within ionomers, even at partially hydrated states. Highly sulfonated poly(phenylene sulfide nitrile) (XESPSN) random network copolymers were synthesized as alternatives to state-of-the-art perfluorinated polymers such as Nafion®. A combination of thermal annealing and cross-linking, which was conducted at 250 °C by simple trimerisation of ethynyl groups at the chain termini, results in a morphological transformation. The resulting nanophase separation between the hydrophilic and hydrophobic domains forms well-connected hydrophilic nanochannels for dramatically enhanced proton conduction, even at partially hydrated conditions. For instance, the proton conductivity of XESPSN60 was 160% higher than that of Nafion® 212 at 80 °C and 50% relative humidity. The water uptake and dimensional swelling were also reduced and mechanical properties and oxidative stability were improved after three-dimensional network formation. The fuel cell performance of XESPSN membranes exhibited a significantly higher maximum power density than that of Nafion® 212 under partially hydrated environments.
An <i>in vivo</i> correlate of exercise-induced neurogenesis in the adult dentate gyrus (2007)

With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate of neurogenesis. First, we used an MRI approach to generate CBV maps over time in the hippocampal formation of exercising mice. Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis. Moreover, exercise-induced increases in dentate gyrus CBV were found to correlate with postmortem measurements of neurogenesis. Second, using similar MRI technologies, we generated CBV maps over time in the hippocampal formation of exercising humans. As in mice, exercise was found to have a primary effect on dentate gyrus CBV, and the CBV changes were found to selectively correlate with cardiopulmonary and cognitive function. Taken together, these findings show that dentate gyrus CBV provides an imaging correlate of exercise-induced neurogenesis and that exercise differentially targets the dentate gyrus, a hippocampal subregion important for memory and implicated in cognitive aging.
HER2: Biology, Detection, and Clinical Implications (2011)

HER2 is an important member of a complex signaling network and when gene amplified, it results in an aggressive subtype of breast cancer. Patients with tumors found to overexpress HER2 protein or to be amplified for the gene are candidates for therapy that significantly reduces mortality.
Erythrobacter flavus sp. nov., a slight halophile from the East Sea in Korea (2003)

Two gram-negative, motile, non-spore-forming, yellow-pigmented and slightly halophilic strains (SW-46T and SW-52) were isolated from sea water of the East Sea, Korea, and subjected to a polyphasic taxonomic study. Strains SW-46T and SW-52 were characterized chemotaxonomically by having ubiquinone-10 (Q-10) as the predominant respiratory lipoquinone and C18:1 omega7c as the major fatty acid. Their DNA G + C content was 64.0-64.1 mol%. Strains SW-46T and SW-52 showed 1 bp difference in their 16S rDNA sequences and a mean DNA-DNA relatedness level of 94.4%. Phylogenetic analysis based on 16S rDNA sequences showed that strains SW-46T and SW-52 fall within the alpha-subclass of the Proteobacteria and form a coherent cluster with Erythrobacter longus, Erythrobacter litoralis and Erythrobacter citreus. Levels of 16S rDNA similarity between strains SW-46T and SW-52 and the type strains of these three Erythrobacter species were 96.5-97.9%. Levels of DNA-DNA relatedness between strains SW-46T and SW-52 and the type strains of E. longus, E. litoralis and E. citreus were 3.6-14.7%. Therefore, on the basis of phenotypic properties, phylogeny and genomic data, strains SW-46T and SW-52 should be placed in the genus Erythrobacter as a novel species, for which the name Erythrobacter flavus sp. nov. is proposed. The type strain is SW-46T (= KCCM 41642T = JCM 11808T).
Discriminative clustering for image co-segmentation (2010)

Purely bottom-up, unsupervised segmentation of a single image into foreground and background regions remains a challenging task for computer vision. Co-segmentation is the problem of simultaneously dividing multiple images into regions (segments) corresponding to different object classes. In this paper, we combine existing tools for bottom-up image segmentation such as normalized cuts, with kernel methods commonly used in object recognition. These two sets of techniques are used within a discriminative clustering framework: the goal is to assign foreground/background labels jointly to all images, so that a supervised classifier trained with these labels leads to maximal separation of the two classes. In practice, we obtain a combinatorial optimization problem which is relaxed to a continuous convex optimization problem, that can itself be solved efficiently for up to dozens of images. We illustrate the proposed method on images with very similar foreground objects, as well as on more challenging problems with objects with higher intra-class variations.
Stochastic Approach to Digital Control Design and Implementation in Power Electronics (2006)

The Office of Graduate Studies has verified and approved the above named committee members. ii ACKNOWLEDGEMENTS I would like to thank my academic advisor, Dr. Hui Li for her guidance and
Molecular mechanism and structure of the <i>Saccharomyces cerevisiae</i> iron regulator Aft2 (2014)

The paralogous iron-responsive transcription factors Aft1 and Aft2 (activators of ferrous transport) regulate iron homeostasis in Saccharomyces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron is low. We present the previously unidentified crystal structure of Aft2 bound to DNA that reveals the mechanism of DNA recognition via specific interactions of the iron-responsive element with a Zn(2+)-containing WRKY-GCM1 domain in Aft2. We also show that two Aft2 monomers bind a [2Fe-2S] cluster (or Fe(2+)) through a Cys-Asp-Cys motif, leading to dimerization of Aft2 and decreased DNA-binding affinity. Furthermore, we demonstrate that the [2Fe-2S]-bridged heterodimer formed between glutaredoxin-3 and the BolA-like protein Fe repressor of activation-2 transfers a [2Fe-2S] cluster to Aft2 that facilitates Aft2 dimerization. Previous in vivo findings strongly support the [2Fe-2S] cluster-induced dimerization model; however, given the available evidence, Fe(2+)-induced Aft2 dimerization cannot be completely ruled out as an alternative Aft2 inhibition mechanism. Taken together, these data provide insight into the molecular mechanism for iron-dependent transcriptional regulation of Aft2 and highlight the key role of Fe-S clusters as cellular iron signals.
Hydroxylation of Nitroarenes with Alkyl Hydroperoxide Anions via Vicarious Nucleophilic Substitution of Hydrogen (1998)

Carbo- and heterocyclic nitroarenes react with anions of tert-butyl and cumyl hydroperoxides in the presence of strong bases to form substituted o- and p-nitrophenols. The reaction usually proceeds in high yields and is of practical value as a method of synthesis and manufacturing of nitrophenols. Orientation of the hydroxylation can be controlled to a substantial extent by selection of the proper conditions. Basic mechanistic features of this process were clarified.
Photodegradation of the textile dye Reactive Black 5 in the presence of semiconducting oxides (1999)

The photocatalytic degradation of Reactive Black 5, a textile azo dye, has been investigated in aqueous heterogeneous solutions containing semiconductor oxides as photocatalysts. The disappearance of the organic molecule follows approximately a pseudo-first kinetic order according to the Langmuir–Hinshelwood model. CO 2, NO3−, and SO4 2− ions have been identified as mineralization products. Various commercial photocatalysts were compared with respect to their decolorization efficiency, as well as the production of CO2. The effect of pH and H2O2 on the reaction rate was ascertained. © 1999 Society of Chemical Industry
<i>In Vitro</i> Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum (2012)

Many successful antimicrobial drugs originate from synthetic dyes. This paper reports the in vitro activity of 14 fluorescent dyes against Plasmodium falciparum. Five of these dyes (Hoechst 33342, MitoRed, DiOC(6), SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against two P. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs against P. falciparum.
On the performance of equalizers for sparse channels (2002)

We consider propagation channels which are sparse, i.e., can be modeled by a finite impulse response filter which has a relatively large order but only a few non-zero taps. An equalizer which makes use of the sparse structure is expected to have better performance than one which does not. We compare the performance of the two types of equalizers by computer simulation.
Giant magnetocaloric effect in Gd5(Si2Ge2) alloy with low purity Gd (2004)

Gd5(Ge1-xSi x), x < 4 based alloys are potential candidates for magnetic refrigeration in the range ~20 - ~290 K. However, one of the greatest obstacles for the use of that technology in large scale is the utilization of high pure Gd metal (99.99 wt. (%)) to produce the GdGeSi alloys, since the impurity elements decrease the intensity of the magnetocaloric effect (EMC)¹. In this work, we prove that annealing of the Gd5Ge2Si2 can promote remarkable values for the EMC in comparison to those obtained for the alloy with high pure Gd. Also, the as cast alloy and the annealed alloy are not monophasic, but have at least two crystalline phases in their microstructure. Results for X-ray analysis, optical and electronic microscopy and magnetization measurements are reported.
Improved synthesis of cubane-1,2,4,7-tetracarboxylic acid (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImproved synthesis of cubane-1,2,4,7-tetracarboxylic acidJeffrey C. Bottaro, Paul E. Penwell, and Robert J. SchmittCite this: J. Org. Chem. 1991, 56, 3, 1305–1307Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00003a071https://doi.org/10.1021/jo00003a071research-articleACS PublicationsRequest reuse permissionsArticle Views557Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Muse: Mapping Understanding and deSign by Example (2008)

A fundamental problem in information integration is that of designing the relationships, called schema mappings, between two schemas. The specification of a semantically correct schema mapping is typically a complex task. Automated tools can suggest potential mappings, but few tools are available for helping a designer understand mappings and design alternative mappings. We describe Muse, a mapping design wizard that uses data examples to assist designers in understanding and refining a schema mapping towards the desired specification. We present novel algorithms behind Muse and show how Muse systematically guides the designer on two important components of a mapping design: the specification of the desired grouping semantics for sets of data and the choice among alternative interpretations for semantically ambiguous mappings. In every component, Muse infers the desired semantics based on the designer's actions on a short sequence of small examples. Whenever possible, Muse draws examples from a familiar database, thus facilitating the design process even further. We report our experience with Muse on some publicly available schemas.
An Intelligent Braille Display Device (1986)

The high cost of braille output devices has prevented their wide use among the visually handicapped. Here, a much cheaper device is implemented.
Nociceptin/Orphanin FQ Microinjected into Hippocampus Impairs Spatial Learning in Rats (1997)

The newly discovered peptide nociceptin/orphanin FQ has been found to increase reactivity to pain and to influence locomotor activity after intracerebroventricular administration. This study investigated the possible role of hippocampal nociceptin/orphanin FQ in spatial learning and in spontaneous locomotion. Male rats were trained in the Morris water task after microinjection of 10 nmol nociceptin/orphanin FQ or artificial cerebrospinal fluid (as control) into the CA3 region of the dorsal hippocampus. Nociceptin/orphanin FQ was found to severely impair spatial learning without interfering with swimming performance. Intrahippocampal injection of nociceptin/ orphanin FQ markedly decreased exploratory locomotor activity including vertical movements (rearing). The data suggest that nociceptin/orphanin FQ is a potent modulator of synaptic plasticity within the hippocampus.
High efficiency GaN switching converter IC with bootstrap driver for envelope tracking applications (2013)

In this paper, we report a DC/DC converter based on GaN HEMT's with a switching frequency of 200 MHz that can be used to generate envelope-modulated power supply voltages for use in envelope tracking power amplifiers. The converter consists of switching circuits using 0.25-um GaN HEMTs, inductor, and low pass filter, and can provide output voltages above 28V. An integrated bootstrap driver of the switching circuits is employed in order to reduce DC power consumption of the driver stage. Generation of envelope power supply voltages for 20 MHz LTE signals was demonstrated using 200 MHz switching rates with efficiency of 73%(including dissipation in final and driver stages). The chip size is 1075×990 um <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Dependence of Thermal Mismatch Broadening on Column Diameter in High-Speed Liquid Chromatography at Elevated Temperatures (2001)

In this paper, we compare a narrow-bore column (2.1-mm i.d.) to a conventional-bore column (4.6 mm i.d.) at elevated temperatures under conditions where thermal mismatch broadening is serious and show that narrow-bore columns offer significant advantages in terms of efficiency and peak shape at higher linear velocities. We conclude that the so-called thermal mismatch broadening effect is largely due to a radial retention factor gradient and not a radial viscosity gradient. The lower volumetric flow rates inherent with the use of narrower columns lead to lower linear velocity in the heater tubing and longer eluent residence times in the heater. Thus, with the same heater tubing at the same column linear velocity, narrow-bore columns give better thermal equilibration between the eluent and the column compared to wider bore columns. This means that high-temperature, ultrafast liquid chromatography no longer requires excessively long preheater tubing to thermally equilibrate the eluent to the column temperature. Consequently, the use of narrow-bore columns at high-temperature improves analysis speed and efficiency over wider bore columns. We also discuss the advantages of using liquid heat-transfer media as compared to air as the heat-transfer media. We show that an air bath ought not be used to heat the mobile phase because at high temperature (>80 degrees C) and high column linear velocity (> 1.5 cm/s) the length of tubing needed to heat the mobile phase to column temperature is prohibitively long. Using accurate, empirical heat-transfer correlations, we estimated the length of tubing needed to heat the eluent as a function of the column linear velocity for both air and liquid heat-transfer media.
Graded index substrate integrated waveguide based directional coupler (2017)

A novel graded index (GRIN) based substrate integrated waveguide (SIW) directional coupler is proposed for bandwidth enhancement. The suppression of higher order modes in the coupling region of the directional coupler is achieved by reduction in the permittivity in the coupling region by the utilization of GRIN substrate. An enhancement in the fractional bandwidth of 7% is achieved by proposed directional coupler based on GRIN SIW substrate as compared to the conventional SIW based coupler. The proposed coupler prototype bandwidth is 49% (8.5 GHz–14GHz).
A Sub-mW All-Digital Signal Component Separator With Branch Mismatch Compensation for OFDM LINC Transmitters (2011)

Linear amplification with nonlinear components (LINC) is an attractive technique for achieving linear amplification with high efficiency. This paper presents a sub-mW all-digital signal component separator (SCS) design for OFDM LINC transmitters, including a phase calculator and a digital-control phase shifter (DCPS) pair. In addition, a digital mismatch compensation scheme is proposed and integrated into the SCS to reduce the design complexity of the power amplifier. This chip is manufactured in a 90 nm standard CMOS process with an active area of 0.06 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The DCPS can generate phase-modulated signals at 100 MHz with 8-bit resolution and RMS error 9.33 ps (0.34°). The phase calculation can be performed at a maximum speed of 50 MHz using a 0.5 V supply voltage, resulting in a 73.88% power reduction. Comparing to state-of-the-art, the power consumption of the overall SCS is only 949.5 μW which minimizes the power overhead for an LINC transmitter. This SCS with the branch mismatch compensation provides a 0.02 dB gain and 0.15° phase fine-tune resolution without adding additional front-end circuits. Considering 1 dB gain and 10° phase mismatch, the system EVM of - 29.81 dB and ACPR of - 34.56 dB can still be achieved for 5 MHz bandwidth 64-QAM OFDM signals.
Toward a Semisynthetic Stress Response System To Engineer Microbial Solvent Tolerance (2012)

Microbial production of useful chemicals is often limited by the toxicity of desired products, feedstock impurities, and undesired side products. Improving tolerance is an essential step in the development of practical platform organisms for production of a wide range of chemicals. By overexpressing autologous heat shock proteins in Escherichia coli, we have developed a modular semisynthetic stress response system capable of improving tolerance to ethanol, n-butanol, and potentially other toxic solvents. Using this system, we demonstrate that a practical stress response system requires both tuning of individual gene components and a reliable framework for gene expression. This system can be used to seek out new interacting partners to improve the tolerance phenotype and can be used in the development of more robust solvent production strains.
Mass Spectrometric Analysis of Exhaled Breath for the Identification of Volatile Organic Compound Biomarkers in Esophageal and Gastric Adenocarcinoma (2015)

Distinct exhaled breath VOC profiles can distinguish patients with esophageal and gastric adenocarcinoma from noncancer controls.
Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography (2009)

HIV-1 protease is a dimeric aspartic protease that plays an essential role in viral replication. To further understand the catalytic mechanism and inhibitor recognition of HIV-1 protease, we need to determine the locations of key hydrogen atoms in the catalytic aspartates Asp-25 and Asp-125. The structure of HIV-1 protease in complex with transition-state analog KNI-272 was determined by combined neutron crystallography at 1.9-A resolution and X-ray crystallography at 1.4-A resolution. The resulting structural data show that the catalytic residue Asp-25 is protonated and that Asp-125 (the catalytic residue from the corresponding diad-related molecule) is deprotonated. The proton on Asp-25 makes a hydrogen bond with the carbonyl group of the allophenylnorstatine (Apns) group in KNI-272. The deprotonated Asp-125 bonds to the hydroxyl proton of Apns. The results provide direct experimental evidence for proposed aspects of the catalytic mechanism of HIV-1 protease and can therefore contribute substantially to the development of specific inhibitors for therapeutic application.
Adsorption of model charged proteins on charged surfaces with grafted polymers (2002)

The adsorption of model charged proteins on charged surfaces with and without grafted polymers is studied using a molecular approach. The ability of the polymer layer to reduce the amount of proteins adsorbed on top of the surface (primary adsorption) and at the same time to increase the adsorption of the proteins on top of the polymer layer (secondary adsorption) is presented. It is found that charging the free ends of the chains can result in an efficient way to enhance adsorption at the tip of the brush. Increasing the surface coverage of the polymers with charged free ends enhances the amount of proteins adsorbed at the tip of the polymer layer, while at the same time strongly reduces the number of proteins adsorbed directly onto the surface. The interplay between the attractive van der Waals protein-surface interactions, the steric polymer-protein interactions and the effect of the electrostatic interactions in determining the final adsorption is discussed. The manipulation of solution conditions to tune the amount of secondary adsorption is presented.