gebhart/patrepeval huggingface dataset:
Transition-metal complexes containing phosphorus ligands. Part III. Convenient syntheses of some triphenylphosphine complexes of the platinum metals (1970)

Convenient, single-stage syntheses have been devised for a range of important hydride-, carbonyl-, and nitrosyl- containing triphenylphosphine complexes of the platinum metals. The reactions are performed in homogeneous, alcoholic solutions from which the required products precipitate or crystallise cleanly; sodium borohydride, aqueous formaldehyde, and N-methyl-N-nitrosotoluene-p-sulphonamide are used as convenient sources of hydride, carbonyl, and nitrosyl ligands respectively. Abstraction of hydrogen chloride to form co-ordinatively unsaturated derivatives is achieved by introduction of triethylamine to the reaction solution. New compounds prepared and characterised include [OsH4(PPh3)3] and [Ru(NO)2(PPh3)2]. The latter compound is the first well characterised dinitrosyl of ruthenium.
Site-Specific Protein N- and O-Glycosylation Analysis by a C18-Porous Graphitized Carbon–Liquid Chromatography-Electrospray Ionization Mass Spectrometry Approach Using Pronase Treated Glycopeptides (2015)

The analysis of N- and O-glycopeptides remains challenging due to the microheterogeneity (different glycoforms attached to one glycosylation site) and macroheterogeneity (site occupancy) of the glycoprotein. Trypsin is by far the most commonly used protease in glycoproteomic studies; however, it often results in long peptides that can harbor more than one glycan which may hamper site identification. The use of unspecific proteases such as Pronase can largely overcome this problem by generating glycopeptides with a small peptide portion. While the resulting glycopeptides are very useful for tandem mass spectrometric investigation, the analysis with conventional 1D-LC-ESI-MS/MS approaches can lead to incomplete glycosylation coverage because of the very heterogeneous physicochemical properties of the glycopeptides depending on the peptide sequence as well as the size and charges of the glycan moiety. Here, we describe a universal workflow for site-specific N- and O-glycopeptide analysis of Pronase treated glycoproteins with integrated, sequential C18 reverse phase and porous graphitized carbon-LC-ESI-QTOF-MS/MS employing a combination of lower- and enhanced-energy collision-induced dissociation. The approach was evaluated on glycoprotein standards and also applied to investigate the glycosylation of human IgG3 providing details on the hitherto uncharacterized glycosylation site Asn392 of the CH3 domain. This analytical tool can be applied to a variety of glycoproteins for site-specific N- and O-glycopeptide analysis, resulting in a good glycopeptide coverage within a single sample run and, thus, requiring only small amounts of sample.
Reduced miR-146a Increases Prostaglandin E2 in Chronic Obstructive Pulmonary Disease Fibroblasts (2010)

miR-146a seems to play a pathogenetic role in the abnormal inflammatory response in COPD. Increased half-life of inflammatory mRNAs is a mechanism of abnormal inflammation in this disease.
Treatment of comorbidity in conduct disorder with attention-deficit hyperactivity disorder (ADHD). (2005)

Conduct disorder (CD) is one of the most common psychiatric disorders in childhood and adolescence. It is characterized by a variety of chronic antisocial behaviors, a repetitive and persistent pattern of behavior that violates the basic rights of others, major age-appropriate societal norms, or both. Aggressive behavior, lying, stealing, fire-setting, and running away from home and school are the most frequent manifestations of CD and are often accompanied by hyperactivity, impulsive behavior, explosiveness, cognitive and learning problems, and poor social skills. The rate of comorbidity is high, with attention-deficit hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) being the most common; comorbid anxiety and depressive disorders are also seen, especially in adolescents. The diagnostic process should include the use of structured interviews, and scores from reliable and valid rating scales that cover all psychiatric disorders must be considered in the differential diagnosis, because CD alone is an extreme rarity and multiple disorders are almost always the rule rather than exception. Treatment should include parenting skills training combined with training of the child to improve his or her relationships with peers, academic performance, and compliance with legitimate demands of authority figures. The appropriate use of medications and integration of patient/parent education and support, as well as individual, group, family, residential, and inpatient treatment may be beneficial for patients with CD and ADHD. The article describes a number of psychopharmacological agents that are used in patients with CD with ADHD and other comorbid disorders. Drugs that may be useful include psychostimulants; atomoxetine (Strattera); antidepressants (imipramine [Tofranil], desipramine [Norpramin]); Selective Serotonin Reuptake Inhibitors (SSRIs); atypical antipsychotics such as risperidone (Risperdal); or mood regulators including lithium (Eskalith).
A novel thermostable xylanase of <i>Paenibacillus macerans</i> IIPSP3 isolated from the termite gut (2012)

Xylanase is an enzyme in high demand for various industrial applications, such as those in the biofuel and pulp and paper fields. In this study, xylanase-producing microbes were isolated from the gut of the wood-feeding termite at 50°C. The isolated microbe produced thermostable xylanase that was active over a broad range of temperatures (40-90°C) and pH (3.5-9.5), with optimum activity (4,170 ± 23.5 U mg⁻¹) at 60°C and pH 4.5. The enzyme was purified using a strong cation exchanger and gel filtration chromatography, revealing that the protein has a molecular mass of 205 kDa and calculated pI of 5.38. The half-life of xylanase was 6 h at 60°C and 2 h at 90°C. The isolated thermostable xylanase differed from other xylanases reported to date in terms of size, structure, and mode of action. The novelty of this enzyme lies in its high specific activity and stability at broad ranges of temperature and pH. These properties suggest that this enzyme could be utilized in bioethanol production as well as in the paper and pulp industry.
Taxation with Representation: Intergovernmental Grants in a Plebiscite Democracy (2006)

Economic theory predicts that unconditional intergovernmental grant income and private income are perfectly fungible. Despite this prediction, the literature on fiscal federalism documents that grant and private income are empirically non-equivalent. A large scale school finance reform in New Hampshire -- the typical school district experienced a 200 percent increase in grant income -- provides an unusually compelling test of the equivalence prediction. Most theoretical explanations for non-equivalence focus on mechanisms which produce public good provision levels which differ from the decisive voter&amp;amp;#x27;s preferences. New Hampshire determines local public goods provision via a form of direct democracy -- a setting which rules out these explanations. In contrast to the general support in the literature for non-equivalence, the empirical estimates in this paper suggest that approximately 92 cents per grant dollar are spent on tax reduction. These results not only document that equivalence holds in a setting with a strong presumption that public good provision decisions reflect the preferences of voters, but also directly confirm the prediction of the seminal work of Bradford and Oates (1971) that lump-sum grant income is equivalent to a tax reduction. In addition, the paper presents theoretical arguments that grant income capitalization and heterogeneity in the marginal propensity to spend on public goods may generate spurious rejections of the equivalence prediction. The heterogeneity argument is confirmed empirically. Specifically, the results indicate that lower income communities spend more of the grant income on education than wealthier communities, a finding interpreted as revealing that the Engel curve for education is concave.
Speech signal detection at the output of a cochlear model (2003)

A two dimensional, linear state-space model of the cochlea of the human ear, the receiver side of the speech communications paradigm, is investigated. The ear is viewed as a serial to parallel converter of information: the input to the cochlear model is a time dependent single channel signal, whereas the output of the cochlear model is a spatially discretized representation of the displacement of the basilar membrane from its rest position. A characterization of the system response of the cochlear filters is given. An approach to detecting known signals at the input using only the information available at the output based upon methods akin to 'beamforming' for a linear array is presented. The detector threshold is set using an adaptive technique that uses spatially local information. Simulation results showing the capabilities of the detection system for processing speech signals are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Toward predicting self-splicing and protein-facilitated splicing of group I introns (2008)

In the current era of massive discoveries of noncoding RNAs within genomes, being able to infer a function from a nucleotide sequence is of paramount interest. Although studies of individual group I introns have identified self-splicing and nonself-splicing examples, there is no overall understanding of the prevalence of self-splicing or the factors that determine it among the >2300 group I introns sequenced to date. Here, the self-splicing activities of 12 group I introns from various organisms were assayed under six reaction conditions that had been shown previously to promote RNA catalysis for different RNAs. Besides revealing that assessing self-splicing under only one condition can be misleading, this survey emphasizes that in vitro self-splicing efficiency is correlated with the GC content of the intron (>35% GC was generally conductive to self-splicing), and with the ability of the introns to form particular tertiary interactions. Addition of the Neurospora crassa CYT-18 protein activated splicing of two nonself-splicing introns, but inhibited the second step of self-splicing for two others. Together, correlations between sequence, predicted structure and splicing begin to establish rules that should facilitate our ability to predict the self-splicing activity of any group I intron from its sequence.
Multiple alkane hydroxylase systems in a marine alkane degrader, <i>Alcanivorax dieselolei</i> B‐5 (2011)

Alcanivorax dieselolei strain B-5 is a marine bacterium that can utilize a broad range of n-alkanes (C(5) -C(36) ) as sole carbon source. However, the mechanisms responsible for this trait remain to be established. Here we report on the characterization of four alkane hydroxylases from A. dieselolei, including two homologues of AlkB (AlkB1 and AlkB2), a CYP153 homologue (P450), as well as an AlmA-like (AlmA) alkane hydroxylase. Heterologous expression of alkB1, alkB2, p450 and almA in Pseudomonas putida GPo12 (pGEc47ΔB) or P. fluorescens KOB2Δ1 verified their functions in alkane oxidation. Quantitative real-time RT-PCR analysis showed that these genes could be induced by alkanes ranging from C(8) to C(36) . Notably, the expression of the p450 and almA genes was only upregulated in the presence of medium-chain (C(8) -C(16) ) or long-chain (C(22) -C(36) ) n-alkanes, respectively; while alkB1 and alkB2 responded to both medium- and long-chain n-alkanes (C(12) -C(26) ). Moreover, branched alkanes (pristane and phytane) significantly elevated alkB1 and almA expression levels. Our findings demonstrate that the multiple alkane hydroxylase systems ensure the utilization of substrates of a broad chain length range.
Relationship between Cation Arrangement and Photocatalytic Activity for Sr−Al−Nb−O Double Perovskite (2010)

The relationship between the photocatalytic activity and the arrangement of metal cations was investigated with Sr-Al-Nb-O double perovskite (SAN) synthesized at 1400 °C for various calcination times using a solid state reaction. Transmission electron microscopic observation revealed that SAN particles had a domain structure of completely B-site ordered (Sr(2)AlNbO(6)) and disordered (SrAl(0.5)Nb(0.5)O(3)) phases. The ordered phase fraction was determined using a newly proposed mixed-phase model for the Rietveld refinement and a method using the relative intensity of the superlattice line of powder X-ray diffraction. It turned out that the mass fraction of the ordered phase in SAN calcined at 1400 °C could be controlled by the calcination time as 33% (10 h), 37% (20 h), 44% (30 h), and 48% (50 h). Photocatalytic activities of SAN for the evolution of H(2) and O(2) respectively from aqueous solutions of methanol and AgF decreased with increasing the calcination time, that is, with increasing the fraction of the ordered phase. These results suggested that the photocatalytic activity of ordered Sr(2)AlNbO(6) should be lower than that of disordered SrAl(0.5)Nb(0.5)O(3). This is practically the first report to reveal the photocatalytic activity of SAN as well as the effect of cation ordering in oxides on the photocatalytic activity.
Derivation of Floquet Eigenvectors Displacement for Optimal Design of LC Tank Pulsed Bias Oscillators (2011)

The paper presents an approximated and compact derivation of the mutual displacement of Floquet eigenvectors in a class of LC tank oscillators with time varying bias. In particular it refers to parallel tank oscillators of which the energy restoring can be modeled through a train of current pulses. Since Floquet eigenvectors are acknowledged to give a correct decomposition of noise perturbations along the stable orbit in oscillator's space state, an analytical and compact model of their displacement can provide useful criteria for designers. The goal is to show, in a simplified case, the achievement of oscillators design oriented by eigenvectors. To this aim, minimization conditions of the effect of stationary and time varying noise as well as the contribution of jitter noise introduced by driving electronics are deduced from analytical expression of eigenvectors displacement.
Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease. (1999)

A population-based case-control study was conducted in the Henry Ford Health System (HFHS) in metropolitan Detroit to assess occupational exposures to manganese, copper, lead, iron, mercury and zinc as risk factors for Parkinson's disease (PD). Non-demented men and women 50 years of age who were receiving primary medical care at HFHS were recruited, and concurrently enrolled cases (n = 144) and controls (n = 464) were frequency-matched for sex, race and age (+/- 5 years). A risk factor questionnaire, administered by trained interviewers, inquired about every job held by each subject for 6 months from age 18 onward, including a detailed assessment of actual job tasks, tools and environment. An experienced industrial hygienist, blinded to subjects' case-control status, used these data to rate every job as exposed or not exposed to one or more of the metals of interest. Adjusting for sex, race, age and smoking status, 20 years of occupational exposure to any metal was not associated with PD. However, more than 20 years exposure to manganese (Odds Ratio [OR] = 10.61, 95% Confidence Interval [CI] = 1.06, 105.83) or copper (OR = 2.49, 95% CI = 1.06,5.89) was associated with PD. Occupational exposure for > 20 years to combinations of lead-copper (OR = 5.24, 95% CI = 1.59, 17.21), lead-iron (OR = 2.83, 95% CI = 1.07,7.50), and iron-copper (OR = 3.69, 95% CI = 1.40,9.71) was also associated with the disease. No association of occupational exposure to iron, mercury or zinc with PD was found. A lack of statistical power precluded analyses of metal combinations for those with a low prevalence of exposure (i.e., manganese, mercury and zinc). Our findings suggest that chronic occupational exposure to manganese or copper, individually, or to dual combinations of lead, iron and copper, is associated with PD.
<b>The Electrical Effect of the Sulfur Pentafluoride Group</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Electrical Effect of the Sulfur Pentafluoride GroupWilliam A. SheppardCite this: J. Am. Chem. Soc. 1962, 84, 16, 3072–3076Publication Date (Print):August 1, 1962Publication History Published online1 May 2002Published inissue 1 August 1962https://pubs.acs.org/doi/10.1021/ja00875a007https://doi.org/10.1021/ja00875a007research-articleACS PublicationsRequest reuse permissionsArticle Views938Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiple uses of the waterfront (1989)

L'auteur se penche sur les consequences de l'introduction (aux E.-U.) de nouvelles utilisations des zones a front d'eau, alors que la navigation commerciale s'y rarefie. Parmi les sujets qu'il aborde citons: la navigation de Sport et de Plaisance, les marinas, les droits des riverains, la protection des cotes, la securite de la navigation, etc.
Python for data analysis data wrangling with Pandas, NumPy, and IPython (2017)

Get complete instructions for manipulating, processing, cleaning, and crunching datasets in Python. Updated for Python 3.6, the second edition of this hands-on guide is packed with practical case studies that show you how to solve a broad set of data analysis problems effectively. You’ll learn the latest versions of pandas, NumPy, IPython, and Jupyter in the process. Written by Wes McKinney, the creator of the Python pandas project, this book is a practical, modern introduction to data science tools in Python. It’s ideal for analysts new to Python and for Python programmers new to data science and scientific computing. Data files and related material are available on GitHub. Use the IPython shell and Jupyter notebook for exploratory computing Learn basic and advanced features in NumPy (Numerical Python) Get started with data analysis tools in the pandas library Use flexible tools to load, clean, transform, merge, and reshape data Create informative visualizations with matplotlib Apply the pandas groupby facility to slice, dice, and summarize datasets Analyze and manipulate regular and irregular time series data Learn how to solve real-world data analysis problems with thorough, detailed examples
Les représentations des empereurs romains Julio-Claudiens en Egypte : bilan d'une analyse (2013)

En 31 av. J.-C., l'Egypte tombe aux mains de l'Empire romain. Pour la première fois de son histoire, le pays va être gouverné par un "pharaon" vivant loin de son sol. En quoi cette situation va modifier la théologie ? Découvrons le fonctionnement d'un temple, son art, ses divinités, le rôle de l'empereur pharaon, sa politique, ... les particularités des édifices d’époque romaine, leur esthétique… entre tradition et innovation.
ANTI-INFLAMMATORY ACTIVITY OF TAXIFOLIN (1971)

Active principles of varied chemical structure isolated from plants possess potent anti-inflammatory activity. The anti-inflammatory activity of triterpenoids, saponins and other natural products has been reported from this laboratory (1-3). The flavonoids viz hesperidin, neohesperidin and naringin have been shown to reduce formalin-induced oedema in the mouse foot (4). The present investigation deals with the study of the anti-inflammatory activity of taxifolin, a flavonoid obtained from Madhuca Butyracea, and the effect of taxifolin on the serum aminotransferase and tissue adenosine triphosphate (ATP) phosphohydrolase activity to elucidate the possible mechanism of its anti-inflammatory activity. The structure of the compound elucidated by Giessmann and Lichner (5) is shown in Fig. 1.
Appearance of a Regenerating(reg) Gene Protein in Pancreatic Islets of Remission BB/Wor||Tky Rats. (1993)

Remission of diabetes, i.e. significant amelioration from absolute insulin-dependency, has been sometimes observed in diabetic BB/Wor//Tky rats which were treated with insulin. In remission BB/Wor//Tky rats, plasma glucose levels improved to near normal level and insulin content was also preserved as much as that between diabetic and non-diabetic rats. In this process, we hypothesized that autoimmune insulitis was suppressed and remaining islet B-cells was restored from severe destruction by recovering in number and/or function. While, recently, a novel regenerating (reg) gene, identified in the regenerating pancreatic islets of surgical models, is reported to be related to the replication of pancreatic B-cells in vitro. Based on these findings, we histologically investigated whether the reg protein could be actually expressed or not in the islets from remission BB/Wor//Tky rats. As expected, reg protein was observed in the islets from remission BB/Wor//Tky rats mainly in accordance with pancreatic B-cells. Thus, the present findings suggested that the regeneration of pancreatic B-cells represented by the expression of reg protein might be, at least in part, relevant to remission induced by insulin therapy in spontaneously occurring Type 1 diabetes in BB/Wor//Tky rats.
Computational complexity issues in operative diagnosis of graph-based systems (1993)

Systems that can be modeled as graphs, such that nodes represent the components and the edges represent the fault propagation between the components, are considered. Some components are equipped with alarms that ring in response to faulty conditions. In these systems, two types of problem are studies: fault diagnosis and alarm placement. The fault diagnosis problems deal with computing the set of all potential failure sources that correspond to a set of ringing alarms. Single faults, where exactly one component can become faulty at any time, are primarily considered. Systems are classified into zero-time and non-zero-time systems on the basis of fault propagation time. The latter are further classified on the basis of knowledge of propagation times. For each of these classes algorithms are presented for single fault diagnosis. The problem of detecting multiple faults is shown to be NP-complete. An alarm placement problem that requires a single fault to be uniquely diagnosed is examined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance of Candida ID, a New Chromogenic Medium for Presumptive Identification of <i>Candida</i> Species, in Comparison to CHROMagar Candida (2001)

Candida ID agar allows identification of Candida albicans and differentiation of other Candida species. In comparison with CHROMagar Candida, we evaluated the performance of this medium directly from 596 clinical specimens. In particular, detection of C. albicans after 24 h of incubation was easier on Candida ID (sensitivity, 96.8%) than on CHROMagar (sensitivity, 49.6%).