gebhart/patrepeval huggingface dataset:
Compromised NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Chronic SIV/SHIV Infection (2013)

Increasing evidence indicates that antibody-dependent cellular cytotoxicity (ADCC) contributes to the control of HIV/SIV infection. However, little is known about the ADCC function of natural killer (NK) cells in non-human primate model. Here we demonstrated that ADCC function of NK cells was significantly compromised in chronic SIV/SHIV infection, correlating closely with the expression of FcγRIIIa receptor (CD16) on NK cells. CD32, another class of IgG Fc receptors, was identified on NK cells with higher expression in the infected macaques and the blockade of CD32 impacted the ability of NK cells to respond to antibody-coated target cells. The inhibition of matrix metalloproteases (MMPs), a group of enzymes normally involved in tissue/receptor remodeling, could restore NK cell-mediated ADCC with increased CD16 expression on macaque NK cells. These data offer a clearer understanding of NK cell-mediated ADCC in rhesus macaques, which will allow us to evaluate the ADCC repertoire arising from preclinical vaccination studies in non-human primates and inform us in the future design of effective HIV vaccination strategies.
SPA: Sparse Photorealistic Animation Using a Single RGB-D Camera (2016)

Photorealistic animation is a desirable technique for computer games and movie production. We propose a new method to synthesize plausible videos of human actors with new motions using a single cheap RGB-D camera. A small database is captured in a usual office environment, which happens only once for synthesizing different motions. We propose a marker-less performance capture method using sparse deformation to obtain the geometry and pose of the actor for each time instance in the database. Then, we synthesize an animation video of the actor performing the new motion that is defined by the user. An adaptive model-guided texture synthesis method based on weighted low-rank matrix completion is proposed to be less sensitive to noise and outliers, which enables us to easily create photorealistic animation videos with new motions that are different from the motions in the database. Experimental results on the public data set and our captured data set have verified the effectiveness of the proposed method.
Univariate and Multivariate analysis in the classification of male volleyball athletes (1999)

O objetivo deste tudo foi comparar a utilização de análises univariadas e multivariadas e suas eventuais diferenças na elaboração de um coeficiente de classificação que possa auxiliar no processo de treinamento a longo prazo e na seleção e promoção de talentos na modalidade esportiva voleibol. A partir dos resultados de testes e medidas cineantropométricas selecionadas de acordo com a especificidade do voleibol, obtidas em uma amostra composta por atletas de voleibol masculino participantes das categorias mirim, infantil, infanto-juvenil, juvenil e principal, foram construídos três coeficientes de classificação: a) coeficiente de classificação por médias (CCM); b) coeficiente utilizando o escore padrão Z (CEZ); e c) coeficiente utilizando análise de componentes principais (CP), que foram comparados com a classificação subjetiva dos próprios treinadores (CT) dos atletas participantes do estudo. Os resultados demonstraram que as análises multivariadas, principalmente o CCM, parecem se ajustar ao que é observado na prática pelos treinadores, oferecendo boas perspectivas para a sua aplicação em estudos futuros. A análise de CEZ também apresentou resultados semelhantes mas, por não considerar as relações existentes entre as variáveis, é mais restrita tomando-se limitada para a complexidade que envolve os processos de seleção e promoção de talentos
Regression of Nephropathy Developed in Diabetes by (Pro)renin Receptor Blockade (2007)

Activation of prorenin by (pro)renin receptor stimulates the tissue renin-angiotensin system and plays a significant role in the development of nephropathy in diabetic animals. This study examined whether (pro)renin receptor blockade inhibits the progression of nephropathy that has already developed in diabetic rats. Seventeen-week-old heminephrectomized streptozotocin-induced diabetic rats with an increased urinary protein excretion and a significant glomerulosclerosis had been treated for 12 wk with the (pro)renin receptor blocker (PRRB), angiotensin-converting enzyme inhibitor (ACEi), or vehicle peptide by using subcutaneously implanted osmotic minipumps. At the end of observation, in diabetic rats that were treated with vehicle, urinary protein excretion was progressively increased and a significant progression of glomerulosclerosis was observed. In diabetic rats that were treated with PRRB, however, no further increase in urinary protein excretion or glomerulosclerosis was observed, but 12-wk treatment with ACEi only attenuated further increases in urinary protein excretion and glomerulosclerosis. The enhanced expression of activated prorenin was observed in the kidneys of diabetic rats that were treated with vehicle, whereas it was markedly suppressed in the kidneys of diabetic rats that were treated with PRRB but not ACEi. These results suggest that (pro)renin receptor blockade does not only inhibit the progression of nephropathy but also reverses the glomerulosclerosis that has already developed in diabetic rats.
A Novel Radar Sensor for the Non-Contact Detection of Speech Signals (2010)

Different speech detection sensors have been developed over the years but they are limited by the loss of high frequency speech energy, and have restricted non-contact detection due to the lack of penetrability. This paper proposes a novel millimeter microwave radar sensor to detect speech signals. The utilization of a high operating frequency and a superheterodyne receiver contributes to the high sensitivity of the radar sensor for small sound vibrations. In addition, the penetrability of microwaves allows the novel sensor to detect speech signals through nonmetal barriers. Results show that the novel sensor can detect high frequency speech energies and that the speech quality is comparable to traditional microphone speech. Moreover, the novel sensor can detect speech signals through a nonmetal material of a certain thickness between the sensor and the subject. Thus, the novel speech sensor expands traditional speech detection techniques and provides an exciting alternative for broader application prospects.
Analysis of Non-Gaussian Nature of Network Traffic (2002)

To study mechanisms that cause the non-Gaussian nature of network traffic, we analyzed IP flow statistics. For greedy flows in particular, we investigated the hop counts between source and destination nodes, and classified applications by the port number. We found that the main flows contributing to the non-Gaussian nature of network traffic were HTTP flows with relatively small hop counts compared with the average hop counts of all flows.
Spectral Feature Selection for Data Mining (2011)

Spectral Feature Selection for Data Mining introduces a novel feature selection technique that establishes a general platform for studying existing feature selection algorithms and developing new algorithms for emerging problems in real-world applications. This technique represents a unified framework for supervised, unsupervised, and semisupervise
Researches on the Effectiveness of Two Chemical Weed Control Strategies in Maize (2010)

Corn, as the main cultivated plant in the Transylvanian agriculture exploitations, remains a preoccupation of scientists to permanently improve the culture technologies or adapt the technology to the modifications occurred in the corn crop habitat, in the specific machinery system or in the economic interests of this crop. The paper presents the results of some stationary experiments developed in a 4 years period: 2004-2007, Noşlac Commune, Alba County which were tested several post-emergence chemical weed control strategies in corn crop. By the research carried out we envisage to clarify certain aspects concerning the specificity of corn crop weeding in Alba County (Commune of Noşlac), the efficacy of two post-emergence weed control strategies for corn crop, and the selectivity of chemical recipes for this crop.
The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK<sub>1</sub> receptor (1995)

1. The selective NK1 receptor antagonist, CP-99,994, produced dose-related (0.1-1.0 mg kg-1, s.c.) inhibition of vomiting and retching in ferrets challenged with central (loperamide and apomorphine), peripheral (CuSO4) and mixed central and peripheral (ipecac, cisplatin) emetic stimuli. 2. Parallel studies with the enantiomer, CP-100,263 (1 mg kg-1, s.c.), which is > 1,000 fold less potent as a NK1 antagonist, indicated that it was without significant effect against CuSO4, loperamide, cisplatin and apomorphine-induced emesis. Against ipecac, it inhibited both retching and vomiting, expressing approximately 1/10th the potency of CP-99,994. 3. The 5-HT3 receptor antagonist, tropisetron (1 mg kg-1, s.c.) inhibited retching and vomiting to cisplatin and ipecac, but not CuSO4 or loperamide. 4. CP-99,994 (1 mg kg-1, i.v.) blocked retching induced by electrical stimulation of the ventral abdominal vagus without affecting the cardiovascular response, the apnoeic response to central vagal stimulation or the guarding and hypertensive response to stimulation of the greater splanchnic nerves. CP-99,994 (1 mg kg-1, i.v.) did not alter baseline cardiovascular and respiratory parameters and it failed to block the characteristic heart rate, blood pressure and respiratory rate/depth changes in response to i.v. 2-methyl-5-HT challenge (von Bezold-Jarisch reflex). 5. Using in vitro autoradiography, [3H]-substance P was shown to bind to several regions of the ferret brainstem with the density of binding in the nucleus tractus solitarius being much greater than in the area postrema. This binding was displaced by CP-99,994 in a concentration-related manner. 6. In dogs, CP-99,994 (40 micrograms kg-1 bolus and 300 micrograms kg-1 h-1, i.v.) produced statistically significant reductions in vomiting to CuSO4 and apomorphine as well as retching to CuSO4. 7. Together, these studies support the hypothesis that the NK1 receptor antagonist properties of CP-99,994 are responsible for its broad spectrum anti-emetic effects. They also suggest that CP-99,994 acts within the brainstem, most probably within the nucleus tractus solitarius although the involvement of the area postrema could not be excluded.
Dynamic Behaviors of Redox Mediators within the Hydrophobic Layers as an Important Factor for Effective Microbial Fuel Cell Operation (2003)

In a mediator-aided microbial fuel cell, the choice of a proper mediator is one of the most important factors for the development of a better fuel cell system as it transfers electrons from bacteria to the electrode. The electrochemical behaviors within the lipid layer of two representative mediators, thionin and safranine O both of which exhibit reversible electron transfer reactions, were compared with the fuel cell efficiency. Thionin was found to be much more effective than safranine O though it has lower negative formal potential. Cyclic voltammetric and fluorescence spectroscopic analyses indicated that both mediators easily penetrated the lipid layer to pick up the electrons produced inside bacteria. While thionin could pass through the lipid layer, the gradual accumulation of safranine O was observed within the layer. This restricted dynamic behavior of safranine O led to the poor fuel cell operation despite its good negative formal potential.
Development of a chip‐based capillary gel electrophoresis method for quantification of a half‐antibody in immunoglobulin G<sub>4</sub> samples (2004)

A method based on microfluidic technology was developed to support quantitative analysis of recombinant monoclonal immunoglobulin G4 (IgG4) antibody samples. The assay was performed on an Agilent 2100 Bioanalyzer in combination with the Protein 200 Plus LabChip Kit and the Protein 200 Plus assay software. Capillary electrophoresis principles have been transferred to a chip format that integrates all separation, staining, virtual destaining, and detection steps. The method is referred to in this paper as chip-based capillary gel electrophoresis (GelChip-CE method). The GelChip-CE method under nonreducing conditions proved to be a quantitative test for half-antibody determination in IgG4 samples. Similar to the traditional nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) method, the GelChip-CE method includes a denaturing step prior to separation. We showed that denaturing the sample by heating resulted in an artificial increase in the amount of half-antibody detected, which could be prevented by addition of N-ethylmaleimide to the sample buffer. The GelChip-CE method allowed for analysis of IgG4 samples with more accuracy, higher precision, and a faster turnaround time than SDS-PAGE and reversed-phase high-performance liquid chromatography (RP-HPLC).
Comparative review of anastrozole, letrozole and exemestane in the management of early breast cancer (2009)

The hormonal therapy of patients with endocrine-sensitive early breast cancer has mainly consisted, for several decades, of the gold standard tamoxifen. The efficacy and favorable toxicity profiles of third-generation aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, in advanced disease led to their development in early breast cancer. Recent results consistently show the superiority of these agents over tamoxifen. Adjuvant trials evaluated AIs using four different therapeutic approaches: (1) Upfront strategy: randomization of newly diagnosed patients: tamoxifen for 5 years versus AI for 5 years. (2) Sequencial strategy: randomization of newly diagnosed patients: tamoxifen (2 - 3 years) followed by AI or the inverse for a total of 5 years versus upfront AI for 5 years. (3) Switch strategy: delayed randomization (or analysis) after 2 - 3 years of tamoxifen (patients free of disease): 2 - 3 years of tamoxifen versus 2 - 3 years of AI (total treatment 5 years). (4) Extended strategy: delayed randomization after 5 years of tamoxifen (patients free of disease): 2 - 5 years of AI versus placebo. Overall, AIs show evidence of superiority over tamoxifen in the adjuvant setting with proven improved efficacy and better toxicity profile. Despite some common characteristics, a body of evidence on AIs indicates some specific differences between the three agents in mechanism of action, pharmacokinetics, efficacy as well as toxicity profiles. Consequently, these hormonal agents may not be considered interchangeable in clinical practice. This review explores available results from AI trials and tries to define their present role in the adjuvant management of postmenopausal patients with breast cancer.
Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem Cells (2008)

Sonic hedgehog (Shh) is necessary for sustaining the proliferation of neural stem cells (NSCs), yet little is known about its mechanisms. Whereas Gli1, Gli2, and Gli3, the primary mediators of Shh signaling, were all expressed in hippocampal neural progenitors, Shh treatment of NSCs induced only Gli1 expression. Acute depletion of Gli1 in postnatal NSCs by short-hairpin RNA decreased proliferation, whereas germline deletion of Gli1 did not affect NSC proliferation, suggesting a difference in mechanisms of Gli1 compensation that may be developmentally dependent. To determine whether Gli1 was sufficient to enhance NSC proliferation, we overexpressed this mitogen and were surprised to find that Gli1 resulted in decreased proliferation, accumulation of NSCs in the G2/M phase of cell cycle, and apoptosis. In contrast, Gli1-expressing lineage-restricted neural precursors demonstrated a 4.5-fold proliferation enhancement. Expression analyses of Gli1-expressing NSCs identified significant induction of Gadd45a and decreased cyclin A2 and Stag1 mRNA, genes involved in the G2-M transition and apoptosis. Furthermore, Gadd45a overexpression was sufficient to partially recapitulate the Gli1-induced G2/M accumulation and cell death of NSCs. In contrast to normal stem cells, tumor-derived stem cells had markedly higher basal Gli1 expression and did not undergo apoptosis with further elevation of Gli1. Our data suggest that Gli1-induced apoptosis may serve as a protective mechanism against premature mitosis and may give insight into mechanisms by which nonmalignant stem cells restrain hyperproliferation in the context of potentially transforming mitogenic signals. Tumor-derived stem cells apparently lack these mechanisms, which may contribute to their unrestrained proliferation and malignant potential.
Achieving <i>In Vivo</i> Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders (2020)

Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery of a series of benzimidazolone inhibitors of the protein-protein interaction between BCL6 and its co-repressors. A subset of these inhibitors were found to cause rapid degradation of BCL6, and optimization of pharmacokinetic properties led to the discovery of 5-((5-chloro-2-((3<i>R</i>,5<i>S</i>)-4,4-difluoro-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2<i>H</i>-benzo[<i>d</i>]imidazol-2-one (CCT369260), which reduces BCL6 levels in a lymphoma xenograft mouse model following oral dosing.
ASSESSMENT OF ESTROGEN AND PROGESTIN THERAPY IN GYNECOLOGY AND OBSTETRICS (1977)

The therapeutic use of estrogen and progestins in gynecologic and obstetric disorders is reviewed. The metabolism of natural estrogens estrone sulfate and synthetic estrogens their mechanism of action and relative binding effectiveness commercially available estrogenic preparations and the therapeutic use of estrogens in cases of panhypopituitarism gonadal dysgenesis menopausal syndrome anovulation inadequate cervical mucus Ashermans syndrome acne and hirsutism dysmenorrhea and excessive tallness prior to menarche as well as the metabolism of progesterone 17alpha-hydroxyprogesterone caproate and orally active synthetic progestins the mechanism of action and toxicity of progesterone and the therapeutic use of progestational drugs in cases of infertility associated with luteal phase deficiency endometriosis dysfunctional uterine bleeding dysmenorrhea precocious puberty and cancer of the endometrium are discussed.
Ozone Generation by a TaO[sub x] and Pt Composite Insulator-Coated Ti Electrode (2005)

The characteristics of a new-type of ozone-generating electrode with a catalyst layer fabricated by thermal decomposition were investigated. The catalyst layer consisted of insulating tantalum oxide and metallic platinum. Ozone generation was observed when the concentration of Ta of the catalyst layer was 70% and above and the maximum current efficiency of ozone generation was 6%. Scanning electron microscopy revealed cracks, which were capable of ozone generation, reaching the Pt buffered layer of the electrode. It is concluded that the cracks were the paths of the electrolyte and that electronic transfer was accomplished on the surface of the buffered layer.
Federated identity management (2005)

Most confidential, valuable resources on the World Wide Web are protected by some form of authentication technology. To access these resources, either via the public Internet or private intranets, users must verify their digital identity. This can range from a simple user-name-password combination to biometric data such as fingerprints to physical objects like hardware tokens and smart cards. Federated identity management would enable individuals to interact with various service providers or Web sites with trust relationships by signing in just once.
Efficiently Retrieving Function Dependencies in the Linux Kernel Using XSB (2013)

In this paper we investigate XSB-Prolog as a static analysis engine for data represented by medium-sized graphs. We use XSB-Prolog to automatically identify function dependencies in the Linux Kernel---queries that are difficult to implement efficiently in a commodity database and that developers often have to identify manually. This project illustrates that Prolog systems are ideal for building tools for use in other disciplines that require sophisticated inferences, because Prolog is both declarative and can efficiently implement complex problem specifications through tabling and indexing.
Fluorous Biphasic Catalysis: Complexation of 1,4,7‐[C<sub>8</sub>F<sub>17</sub>(CH<sub>2</sub>)<sub>3</sub>]<sub>3</sub>‐1,4,7‐Triazacyclononane with [M(C<sub>8</sub>F<sub>17</sub>(CH<sub>2</sub>)<sub>2</sub>CO<sub>2</sub>)<sub>2</sub>] (M = Mn, Co) To Provide Perfluoroheptane‐Soluble Catalysts for Alkane and Alkene Functionalization in the Presence of <i>t</i>‐BuOOH and O<sub>2</sub> (1997)

An autoxidation mechanism was involved in the oxidation of alkanes and alkenes with tBuOOH and O2 under conditions of fluorous biphasic catalysis. The catalytically active complexes are soluble in perfluoroheptane and form in situ from ligand 1 and the Mn2+ complex 2 with polyfluorinated carboxylate ligands (fluoroponytails).
Properties and Limitations of Hologram Recording Materials (1969)

The role of the recording material in holographic imaging is reviewed. Following a general classification of holograms into four basic types, the thick and thin amplitude and phase holograms, a discussion is given of the diffraction efficiency and other intrinsic characteristics of each of these types. The effects of zero spread nonlinearities in hologram recording are examined, and the limitations they impose on the usable diffraction efficiency of the various hologram types are discussed. The effect of the recording material modulation transfer function is treated by means of a fictitious mask model which facilitates prediction of the recordable object field and resolution. The noise characteristics of recording media are discussed in terms of their effect on holographic recording. Some examples of noise limitations on holographic information recording by silver halide emulsions are examined, as are the effects of such limitations on the dynamic range of holography. The effects of silver halide grain noise in conventional and holographic recording are compared, showing the conditions under which better performance can be achieved in the latter by a given emulsion. The characteristics of several nonsilver halide hologram recording materials are briefly summarized.
Bildübertragungsweg mit Frequenzmodulation in einem Glasfaser-Teilnehmernetz (1984)

Transmission d'images de visiophone et de television dans un reseau local. Essai sur deux reseaux BIGFON
The Internet Protocol version 6 (1998)

Today, the World Wide Web and the Internet are quickly becoming a ubiquitous part of modern life. The Internet operates using the Internet Protocol (IP) as the base. This protocol has worked well for a number of years. However, IP version 4 (IPv4) is showing its age as unexpected growth problems have appeared. Most notable is the rapid consumption of network addresses and the explosion in performance requirements for intermediate routing nodes. IPv4 was deployed when exceeding the theoretical maximum number of four billion nodes was not a possibility. With the advancements and the proliferation of computer technology, that limit will be reached in the next decade. The paper discusses version 6 of the Internet Protocol.
Plan averaging for multicriteria navigation of sliding window IMRT and VMAT (2014)

The proposed method enables the navigation of deliverable Pareto optimal plans directly, i.e., interactive multicriteria exploration of deliverable sliding window IMRT and VMAT plans, eliminating the need for a sequencing step after navigation and hence the dose degradation that is caused by such a sequencing step.