gebhart/patrepeval huggingface dataset:
LSST communications middleware implementation (2016)

The LSST communications middleware is based on a set of software abstractions; which provide standard interfaces for common communications services. The observatory requires communication between diverse subsystems, implemented by different contractors, and comprehensive archiving of subsystem status data. The Service Abstraction Layer (SAL) is implemented using open source packages that implement open standards of DDS (Data Distribution Service1) for data communication, and SQL (Standard Query Language) for database access. For every subsystem, abstractions for each of the Telemetry datastreams, along with Command/Response and Events, have been agreed with the appropriate component vendor (such as Dome, TMA, Hexapod), and captured in ICD's (Interface Control Documents).The OpenSplice (Prismtech) Community Edition of DDS provides an LGPL licensed distribution which may be freely redistributed. The availability of the full source code provides assurances that the project will be able to maintain it over the full 10 year survey, independent of the fortunes of the original providers.
Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment (2015)

Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-life antibiotics is still uncharacterized. Here we use a mouse model mimicking paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with a beta-lactam or macrolide alters both host and microbiota development. Early-life PAT accelerates total mass and bone growth, and causes progressive changes in gut microbiome diversity, population structure and metagenomic content, with microbiome effects dependent on the number of courses and class of antibiotic. Whereas control microbiota rapidly adapts to a change in diet, PAT slows the ecological progression, with delays lasting several months with previous macrolide exposure. This study identifies key markers of disturbance and recovery, which may help provide therapeutic targets for microbiota restoration following antibiotic treatment.
Study of IEEE 802.1p GARP/GMRP Timer Values* (1997)

As new services requiring multicast communications become more common, the deployment of selective multicasting in bridged LANs becomes essential. The GARP/GMRP protocol, defined in the IEEE 802.1p standard, addresses this issue. The performance of this protocol depends heavily on the values of the various timers that control it. In this paper we study the performance of GARP/GMRP in terms of response time, traffic overhead created by the protocol&apos;s control messages, and other artifacts which arise from the particular operation of the protocol. We analyze the sensitivity of the various performance measures to various timers used in the protocol, and find the appropriate values to use for these timers. This performance assessment is done by means of computer simulation focusing on 10Base-T and 100Base-T network configurations. Usage scenarios are designed appropriately to bring out the specific effects of interest. I. Introduction Bridges are used to interconnect several LAN segments s...
[Liver transplantation for alcoholic liver disease]. (2001)

Alcoholic cirrhosis is a major public health issue in France. The prevalence of alcoholic cirrhosis and the number of potential candidates for liver transplantation is unknown but certainly underestimated. Despite physicians' ethical reserves concerning this self-inflicted disease and the public's misgivings, liver transplantation for alcoholic cirrhosis can provide survival rates comparable with those observed for other chronic liver diseases. in this indication, liver transplantation if often associated with a low risk of acute rejection and a high rate cancer of the upper respiratory and digestive tracts. The risk of recurrent alcoholism after liver transplantation is also a major problem. Its prevalence varies from 10 to 50%, depending on the assessment criteria, and the rate recurrent risk for the liver graft (alcohol intake>40 g/d) is to the order of 10%. These figures illustrate the importance of careful management and support for these patients. At least 6 months weaning from alcohol is a commonly accepted selection criterion for transplantation candidates. Criteria for liver transplantation generally include patients aged under 65 years, weaned for more than 6 months, with Child C cirrhosis or less, uncontrollable digestive tract hemorrhage, spontaneous severe infection, hepatorenal syndrome, hepatopulmonary syndrome, or multifocal hepatocellular carcinoma if the largest nodule measures less than 3 cm. Acute alcoholic hepatitis is a severe disease, fatal in 50% of the cases, and resistant tot corticosteroid therapy. Liver transplantation in this subpopulation of often young patient who have not achieved weaning merits further evaluation.
Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs (2006)

DISC1 has been identified as a schizophrenia susceptibility gene based on linkage and SNP association studies and clinical data suggesting that risk SNPs impact on hippocampal structure and function. In cell and animal models, C-terminus-truncated DISC1 disrupts intracellular transport, neural architecture and migration, perhaps because it fails to interact with binding partners involved in neuronal differentiation such as fasciculation and elongation protein zeta-1 (FEZ1), platelet-activating factor acetylhydrolase, isoform Ib, PAFAH1B1 or lissencephaly 1 protein (LIS1) and nuclear distribution element-like (NUDEL). We hypothesized that altered expression of DISC1 and/or its molecular partners may underlie its pathogenic role in schizophrenia and explain its genetic association. We examined the expression of DISC1 and these selected binding partners as well as reelin, a protein in a related signaling pathway, in the hippocampus and dorsolateral prefrontal cortex of postmortem human brain patients with schizophrenia and controls. We found no difference in the expression of DISC1 or reelin mRNA in schizophrenia and no association with previously identified risk DISC1 SNPs. However, the expression of NUDEL, FEZ1 and LIS1 was each significantly reduced in the brain tissue from patients with schizophrenia and expression of each showed association with high-risk DISC1 polymorphisms. Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia.
Development of a 7DOF soft manipulator arm for the compliant humanoid robot COMAN (2014)

This paper presents the design and implementation of an intrinsically soft arm system for the COMpliant huMANoid COMAN robot. The two arms (left and right) use state-of-the-art technologies on actuator design that combine both active and passive compliance principles. Robustness of the arms is ensured by integrating intrinsic Series Elastic Actuation (SEA) into the joints to protect the arm at the initial time of the impacts while impedance control based on joint torque sensing and feedback permits the regulation of arm stiffness and damping properties and provides enhanced physical interaction performance. The tuning of the intrinsic stiffness level of the compliant joints is performed by a systematic method to obtain desired performance. A rich sensing system is developed to allow implementation of advanced control algorithms. The functionality of the arms was validated in several tasks requiring high payload, rich sensing ability, and compliant interaction.
Identification and Qualification of Shale Annular Barriers Using Wireline Logs During Plug and Abandonment Operations (2009)

Abstract It has long been recognised that during and after drilling through certain formations, the rock moves inward and begins to close off the well. Normally this phenomenon is considered undesirable since it can cause problems for drilling and casing running. It can however be put to good use as the mechanism to create an annular barrier behind casing. In order to extend the life of a number of North Sea brown fields many well slots on production platforms and sub-sea templates are being re-used. This process involves permanent plug and abandonment of the old well track prior to sidetrack drilling into a fresh area of the reservoir. Norwegian Continental Shelf (NCS) regulatory requirements dictate that compliant procedures for well abandonment require the establishment of double barriers to avoid leakage from the reservoir. With a shortage of sufficient traditional cement barriers these wells often need costly remedial work in order to meet abandonment requirements. Traditional sonic and ultrasonic azimuthal bond logging provides information on the material immediately behind the casing. Many such bond logs show solid material behind the casing far above the theoretical cement top. Clear correlation of this bonding pattern to shales, known to cause problems during drilling, indicates that the shale has sealed off the annular region and that it is the presence of such formation material that results in a good bond log response Logging and pressure testing sealed off zones in a number of wells allowed the bond log response to be qualified for a certain formation without further pressure testing. In this manner logs can provide a clear answer of whether shale successfully seals off certain zones and consequently provides a natural annular barrier. This technique has been employed successfully on over 40 wells, proving non-destructively that high quality natural annular barriers had formed, resulting in elimination of complex remedial work and substantial cost savings.
Protein Kinase Bα/Akt1 Regulates Placental Development and Fetal Growth (2003)

Protein kinase B alpha (PKB alpha/Akt1) is implicated in the regulation of metabolism, transcription, cell survival, angiogenesis, cell migration, growth, and tumorigenesis. Previously, it was reported that PKB alpha-deficient mice are small with increased neonatal mortality (Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., and Birnbaum, M. J. (2001) J. Biol. Chem. 276, 38349-38352 and Chen, W. S., Xu, P. Z., Gottlob, K., Chen, M. L., Sokol, K., Shiyanova, T., Roninson, I., Wenig, W., Suzuki, R., Tobe, K., Kadowaki, T., and Hay, N. (2001) Genes Dev. 15, 2203-2208). Here we show that PKB alpha is widely expressed in placenta including all types of trophoblast and vascular endothelial cells. Pkb alpha-/- placentae display significant hypotrophy, with marked reduction of the decidual basalis and nearly complete loss of glycogen-containing cells in the spongiotrophoblast, and exhibit decreased vascularization. Pkb alpha-/- placentae also show significant reduction of phosphorylation of PKB and endothelial nitric-oxide synthase. These defects may cause placental insufficiency, fetal growth impairment, and neonatal mortality. These data represent the first evidence for the role of PKB alpha and endothelial nitricoxide synthase in regulating placental development and provide an animal model for intrauterine growth retardation.
A One-Pot Condensation of Pyrones and Enals. Synthesis of 1<i>H</i>,7<i>H</i>-5a,6,8,9-Tetrahydro-1-oxopyrano[4,3-<i>b</i>][1]benzopyrans (1997)

Condensation of various 6-substituted 4-hydroxypyrones 1 with 1-cyclohexenecarboxaldehydes in the presence of l-proline in ethyl acetate gave high yields of substituted 1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans. The reaction presumably occurs via the 1,2-addition of the pyrone with the aldehyde followed by dehydration and then cyclization through a 6Π electrocyclic process. A remarkable asymmetric induction was obtained from a stereogenic center (C4) of the cyclohexenecarboxaldehyde [such as (S)-perillaldehyde] to provide only the C5a,7-trans tricyclic pyrone products. On the other hand, condensation of 3-(formyloxy)- or 3-hydroxy-2-methyl-1-cyclohexenecarboxaldehydes with pyrones 1 gave mixtures of C5a,6−cis and -trans products. Several of the tricyclic pyrones strongly inhibit acetylcholinesterase activity, DNA synthesis, and tumor cell growth in vitro.
Measurement and Calculation of Refraction in Experimental Keratophakia with Hydrophilic Lenses (1976)

Measurements of the dioptric power of the corneas of 10 rabbit eyes were made after performance of keratophakia. The material of the implanted intracorneal lenses was HEMA (hydroxyethylmethacrylate). The results showed an approximate congruence of calculation of the postoperative dioptric power with two different formulas and the dioptric power determined by skiascopy.
Control of polymer structure by chain transfer processes (1996)

Abstract Chain transfer can be performed effectively by a mechanism of addition‐fragmentation with appropriately substituted allylic compounds, vinyl ethers and thionoesters. Selection of substituents allows the optimization of chain transfer activity and the preparation of macromonomers and other end‐functional polymers from acrylates, methacrylates, styrene and vinyl acetate. The addition‐fragmentation concept has been extended to the free radical ring‐opening polymerization of cyclic allylic sulfides.
Enediynes as Antitumor Compounds:  Synthesis of Tetrahydropyridine Derivatives (1996)

Enediyne anticancer antibiotics are a rapidly emerging class of compounds derived from natural sources. Many synthetic approaches for the construction of simpler compounds containing this pharmacophore have recently been published. Most of these approaches use the quinoline ring as the heterocyclic moiety . In this paper, we describe a synthetic route for the preparation of enediyne systems 14 and 15, which include in their structure a tetrahydropyridine ring and are related to dynemicin A. Their stereochemistries were determined using NOESY and COSY-NMR. Finally, compounds derived from linkage to intercalating carriers, such as a fluorene ring to enediyne 15 or a naphthalimide ring to acyclic enediyne 6, were prepared.
The First Knockout Mouse Model of Retinoblastoma (2004)

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene identified in humans (Friend, et al., 1986) and the first tumor suppressor gene knocked out by targeted deletion in mice (Jacks, et al., Clarke, et al., Lee, et al., 1992). Children with a germline mutation in one of their RB1 alleles are likely to experience bilateral multifocal retinoblastoma; however, mice with a similar disruption of Rb1 do not develop retinoblastoma. The absence of a knock-out mouse model of retinoblastoma has slowed the progress toward developing new therapies and identifying secondary genetic lesions that occur after disruption of the Rb signaling pathway. Several advances have been made, over the past several years, in our understanding of the regulation of proliferation during retinal development (Zhang, et al., 2004; Dyer J, 2004; Dyer, Cepko, 2001) and we have built upon these earlier studies to generate the first nonchimeric knock-out mouse model of retinoblastoma. These mice are being used as a preclinical model to test new therapies for retinoblastoma and to elucidate the downstream genetic events that occur after inactivation of Rb1 or its related family members.
A new approach to continuous emulsion polymerization (1993)

Abstract The application of a continuous Couette‐Taylor vortex reactor to continuous emulsion polymerization was studied. First, the mixing characteristics of the reactor were examined by the stimulus‐response method. It was found that the reactor performance was similar to that of a continuous flow reactor consisting of more than 60 well‐stirred tanks in series if the reactor was properly designed and operated near the critical Taylor number. It was also demonstrated by a comparison of the particle size distributions of the latexes produced in a batch reactor and in the continuous Couette‐Taylor vortex reactor that the continuous reactor could produce latex particles with fairly narrow size distribution. Furthermore, since no stirrer is involved, this continuous reactor is suited for the purpose of avoiding coagulation of latex particles that are very sensitive to mechanical shear.
Visual Backpropagation (2019)

We show how a declarative functional programming specification of backpropagation yields a visual and transparent implementation within spreadsheets. We call our method Visual Backpropagation. This backpropagation implementation exploits array worksheet formulas, manual calculation, and has a sequential order of computation similar to the processing of a systolic array. The implementation uses no hidden macros nor user-defined functions; there are no loops, assignment statements, or links to any procedural programs written in conventional languages. As an illustration, we compare a Visual Backpropagation solution to a Tensorflow (Python) solution on a standard regression problem.
Resveratrol in Wine: Extraction From Skin During Fermentation and Post-fermentation Standing of Must From Gamay Grapes (1996)

Resveratrol (<i>cis</i>- and <i>trans</i>-isomers) was analyzed in skin, seeds and must of grape berries of Gamay from starting must to skin separation and in wine after malolactic fermentation. Its concentration increases in must while decreasing in skin and remains quite constant in seeds during alcoholic fermentation. Extraction from the skin correlates well with the increase of ethanol concentration in must up to day 6. After malolactic fermentation, the amount of resveratrol is about twice that measured at the end of alcoholic fermentation indicating a pool of resveratrol probably in the form of glucosides and (or) as on oligomeric form from which free resveratrol could be liberated by enzymatic activity of malolactic bacteria.
An Investigation of Self-Absorption and Corresponding Spectral Shift in Phosphors (2012)

Many light emitting diode (LED) phosphors have overlapping emission and absorption bands, such as Ce 3+ -doped garnets and Eu 2+ -doped silicates, nitrides, and oxynitrides. These overlapping bands inevitably lead to self-absorption effects through either non-radiative energy transfer mediated via electron-electron correlation process or actual emission and radiative energy transfer which involves emission and absorption of a photon due to spectral overlap. The first process has been often discussed in the literature. The second process has been investigated in this work through a semi-quantitative formalism. Spectral shift, changes in emission peak shape, photoluminescent conversion efficiency, and phosphor characterization are discussed in light of self-absorption. The simulated results are compared to experimental data and shown to correlate well with observed data.
Putting the holy back in to paediatrics. (1998)

The author discusses her research into the lack of holistic care delivery in paediatrics, especially with families who had a child with a life threatening condition. The family was not treated as a unit nor was a multidisciplinary approach to planning care adopted. The author has developed a model of care. (non-author abstract)
Three-dimensional imaging of random radiation sources (1996)

A method to image random three-dimensional source distributions is proposed. We show that, by using a Michelson stellar interferometer in a prescribed fashion, one is able to measure a special form of a threedimensional degree of coherence. The inverse Fourier transform of this coherence function yields the threedimensional intensity distribution of the source as seen from the paraxial far zone.
Catellibacterium nectariphilum gen. nov., sp. nov., which requires a diffusible compound from a strain related to the genus Sphingomonas for vigorous growth (2004)

A bacterial strain, designated AST4(T), was isolated from activated sludge. The bacterium did not show significant growth on nutrient broth, but growth was clearly stimulated by addition of supernatant from other bacterial cultures. Culture filtrate of a strain related to the genus Sphingomonas in particular increased the cell yield and growth rate of strain AST4(T). Phylogenetic analysis based on the 16S rRNA gene sequences showed that strain AST4(T) is located within the 'Rhodobacter group' in the alpha-3 subclass of Proteobacteria, but is clearly distant from related genera in this group such as Paracoccus, Rhodobacter and Rhodovulum. Strain AST4(T) is a Gram-negative, non-motile, rod-shaped (0.6-0.8x1.3-2.0 micro m) and aerobic bacterium. It was not able to reduce nitrate to nitrite or N(2). No phototrophic growth was observed. Optimal growth occurred at 30 degrees C and pH 6.5-7.5. The dominant cellular fatty acid in the isolate was C(18 : 1)cis11. Ubiquinone-10 was the major respiratory quinone. The G+C content was 64.5 mol% (by HPLC). Based on the phylogenetic and phenotypic traits, the name Catellibacterium nectariphilum gen. nov., sp. nov. is proposed for this isolate; the type strain is AST4(T) (=NBRC 100046(T)=JCM 11959(T)=DSM 15620(T)).
Entacapone Prolongs the Reduction of PLM by Levodopa/Carbidopa in Restless Legs Syndrome (2007)

Single doses of LCE tablets decreased PLMs in a dose-related manner in RLS patients. Prolonged effects of levodopa on PLMs suggest that, compared with standard levodopa, this new levodopa formulation provides longer symptom control throughout the night in patients with previously untreated RLS.
Molecular recognition: hydrogen bonding and stacking interactions stabilize a model for nucleic acid structure (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular recognition: hydrogen bonding and stacking interactions stabilize a model for nucleic acid structureJulius Rebek Jr., B. Askew, P. Ballester, C. Buhr, S. Jones, D. Nemeth, and K. WilliamsCite this: J. Am. Chem. Soc. 1987, 109, 16, 5033–5035Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ja00250a051https://doi.org/10.1021/ja00250a051research-articleACS PublicationsRequest reuse permissionsArticle Views706Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dual-mode microwave cavity for fast identification of liquids in bottles (2011)

An open metal cavity loaded with a ceramic dielectric resonator and a lumped inductor - capacitor structure allows for simultaneous excitation of the TE <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">01δ</sub> dielectric resonator mode at 2 GHz and a lumped element mode at 100 MHz. The measured quality factors are about 7,000 and 400, respectively. Both modes exhibit strongly overlapping evanescent fields above the aperture outside the cavity. These fields can be used for dielectric and conductivity measurements on liquids stored in non-metallic bottles. The simultaneous use of both modes enables liquid category identification within one second. This method has been successfully applied for bottle scanning in checkpoints.