gebhart/patrepeval huggingface dataset:
Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress (1993)

Conference Article| November 01 1993 Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress Marla J. Berry; Marla J. Berry * *To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar P. Reed Larsen P. Reed Larsen 1Thyroid Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston MA 02115, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (4): 827–832. https://doi.org/10.1042/bst0210827 Article history Received: July 30 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Marla J. Berry, P. Reed Larsen; Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress. Biochem Soc Trans 1 November 1993; 21 (4): 827–832. doi: https://doi.org/10.1042/bst0210827 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: SECIS, selenocysteine-insertion sequence, 5′DI, type I iodothyronine 5′ deiodinase, GPX, glutathione peroxidase, fDH, formate dehydrogenase H, Sel P, selenoprotein P, 3′ ut, 3′ untranslated This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
High-resolution electron microscopy studies of non-graphitizing carbons (1997)

Abstract High-resolution electron microscopy is used to study the structure of two typical non-graphitizing carbons before and after heat treatment at temperatures in the range 2100–2600°C. It is found that these heat treatments can result in the formation of closed carbon nanoparticles, which are apparently fullerene-like in structure. This suggests that fullerene-like elements were present in the original carbons and leads us to propose a new model for the structure of non-graphitizing carbons.
Identification of Peptide Ligand-binding Domains within the Human Motilin Receptor Using Photoaffinity Labeling (2001)

The cDNA encoding the human motilin receptor was recently cloned and found to represent a G protein-coupled receptor that is structurally related to the growth hormone secretagogue receptors. Together, these represent a new Class I receptor family. Our aim in the present work is to gain insight into the molecular basis of binding of motilin to its receptor using photoaffinity labeling. To achieve this, we developed a Chinese hamster ovary cell line that overexpressed functional motilin receptor (CHO-MtlR; 175,000 sites per cell, with K(i) = 2.3 +/- 0.4 nm motilin and EC(50) = 0.3 +/- 0.1 nm motilin) and a radioiodinatable peptide analogue of human motilin that incorporated a photolabile p-benzoyl-l-phenylalanine (Bpa) residue into its pharmacophoric domain. This probe, [Bpa(1),Ile(13)]motilin, was a full agonist at the motilin receptor that increased intracellular calcium in a concentration-dependent manner (EC(50) = 1.5 +/- 0.4 nm). This photolabile ligand bound specifically and with high affinity to the motilin receptor (K(i) = 12.4 +/- 1.0 nm), and covalently labeled that molecule within its M(r) = 45,000 deglycosylated core. Cyanogen bromide cleavage demonstrated its covalent attachment to fragments of the receptor having apparent M(r) = 6,000 and M(r) = 31,000. These were demonstrated to represent fragments that included both the first and the large second extracellular loop domains, with the latter representing a unique structural feature of this receptor. The spatial approximation of the pharmacophoric domain of motilin with these receptor domains support their functional importance as well.
Inhibition of coronary blood flow by a vascular waterfall mechanism. (1975)

The mechanism whereby systole inhibits coronary blood flow was examined. A branch of the left coronary artery was maximally dilated with an adenosine infusion, and the pressure-flow relationship was obtained for beating and arrested states. The pressure-flow curve for the arrested state was shifted toward higher pressures and in the range of pressures above peak ventricular pressure was linear and parallel to that for the arrested state. Below this range the curve for the beating state converged toward that for the arrested state and was convex to the pressure axis. These results were compared with a model of the coronary vasculature that consisted of numerous parallel channels, each responding to local intramyocardial pressure by forming vascular waterfalls. When intramyocardial pressure in the model was assigned values from zero at the epicardium to peak ventricular pressure at the endocardium, pressure-flow curves similar to the experimental ones resulted. Thus, we conclude that systole inhibits coronary perfusion by the formation of vascular waterfalls and that the intramyocardial pressures responsible for this inhibition do not significantly exceed peak ventricular pressure.
A survey on wavelet applications in data mining (2002)

Recently there has been significant development in the use of wavelet methods in various data mining processes. However, there has been written no comprehensive survey available on the topic. The goal of this is paper to fill the void. First, the paper presents a high-level data-mining framework that reduces the overall process into smaller components. Then applications of wavelets for each component are reviewd. The paper concludes by discussing the impact of wavelets on data mining research and outlining potential future research directions and applications.
A holistic environment for the design and execution of self-adaptive clinical pathways (2009)

As scientific achievements in the area of Healthcare have evolved during the last decade, inevitably there has been an increase of treatment quality. One of the challenges to be confronted is the personalization of treatment since each patient constitutes a unique case. The personalization requires the continuous reconfiguration of the treatment schemes since the clinical status of each patient and circumstances inside a healthcare organization constantly change. In this paper we present a holistic software environment that provides an IT solution concerning the real-time adaptation of healthcare processes. The software comprises a healthcare process execution engine assisted by a semantic info-structure for reconfiguring the pathways. The semantic info-structure utilizes an ontology enclosing the required knowledge and a semantic rule-set. During the execution of clinical pathways, the system reasons over the rules, the knowledge and information, and reconfigures the next steps of the treatment. The results of the rule-set execution may generate knowledge objects to be inserted in the ontology. A graphical designer is provided for the definition of the rule-set for the clinical pathways adaptation.
Alveolar ridge widening by distraction osteogenesis: a case report. (2001)

Alveolar width deficiencies have generally been corrected by guided tissue regeneration or bone augmentation with and without membranes. The use of distraction osteogenesis is proposed for the correction of horizontal alveolar width defects. In this case report, horizontal bone generation by distraction osteogenesis was achieved prior to implant placement. Following implant restoration, favorable bone response was observed after two years of function. Distraction osteogenesis to widen the alveolus may prove to be a clinically useful treatment option in selected cases.
Thin film thickness variation measurement using dual LEDs and reflectometric interference spectroscopy model in biosensor (2010)

The potential of thin film thickness variation measurement method, reflectometric interference spectroscopy (RIfS), for a compact label-free biosensor is investigated. A model to estimate thickness variation is built based on RIfS. A set-up of the sensor having dual Light Emitting Diodes (LEDs) and one photo detector are introduced. To verify the model, sample chips with different thicknesses of silica film layers ranging from 2 to 20nm are used in the experiment. The estimated values are compared with their reference values which are measured by an Atomic Force Microscopy (AFM). Since the chosen LEDs' wavelength is not an ideal one, the comparison shows that the model underestimates the thickness variation. By using dual LEDs and a photo detector with the reliable model, the handheld device for transparent thin film measurement will become practical.
Nanostructured cathode materials: a key for better performance in Li-ion batteries (2011)

Battery technology plays critical role under clean energy systems because it contributes for the reduction of greenhouse gas emissions. Breakthroughs in cathodes, anodes, and electrolyte materials are needed to reach high power and energy density in lithium ion batteries. The electrochemical performance (cycling stability, power density, and reversibility) depends on the morphological and compositional characteristics of the electrode materials, which could be controlled during the synthesis and also the annealing process. Enormous leverage can result from the advances in nanostructured electrode materials. Nano sized electrodes exhibit minimal impedance growth, which means no substantial loss of power with cycling, also increase the electrode/electrolyte contact area, which in turn increase the charge/discharge rate to achieve maximum power. This report reviews novel nanostructured cathode materials and their influence on the electrochemical performance of lithium ion batteries.
Inhibition of vaccinia virus growth and virus-specific RNA synthesis by 3'-O-methyl adenosine and 3'-O-methyl guanosine (1983)

The 5' triphosphates of the methylated nucleoside analogs 3'-O-methyl adenosine and 3'-O-methyl guanosine are RNA chain terminators in vitro. However, anticellular or antiviral effects of 3'-O-methylated nucleosides or nucleotides have not been investigated. This is presumably because of the assumption that cellular kinases will be unable to phosphorylate the nucleosides. We report here that contrary to this assumption, 3'-O-methyl adenosine and to a lesser extent 3'-O-methyl guanosine are potent inhibitors of vaccinia virus growth in L-cells and Vero cells, without having a significant effect on cell growth at concentrations required to inhibit virus growth. Experiments revealed that early virus-specific RNA synthesis was preferentially inhibited by both 3'-O-methyl adenosine and 3'-O-methyl guanosine.
Evaluation of biplane color Doppler transesophageal echocardiography in 200 consecutive patients. (1992)

This modality greatly facilitates a three-dimensional comprehension of cardiovascular lesions and flow dynamics, especially in aortic dissection and MR, and its safety was demonstrated. Our data demonstrate the usefulness of this new technique in comparison with conventional single-plane TEE.
Measurements of ambient ammonia using a tunable diode laser absorption spectrometer: Characteristics of ambient ammonia emissions in an urban area of New York City (2006)

A tunable diode laser absorption spectrometer (TDLAS) was deployed during the PMTACS‐NY Supersite winter 2004 intensive field campaign at Queens College in New York City to measure the ambient gaseous ammonia. For the characterization of ammonia emissions from the mobile sources, a LI‐7000 CO 2 /H 2 O analyzer was also collocated with the TDLAS to measure ambient CO 2 and H 2 O vapor. The field measurements and laboratory calibration with certified ammonia standard have been used to evaluate the performance of the TDLAS system. High time resolved TDLAS ambient ammonia measurements performed at Queens College from 10 January to 6 February showed high variability, with NH 3 concentrations ranging from below the detection limit (0.1 ppb) to maxima of 197.4 ppb and a mean value of 0.8 ppb over the entire campaign. Many high‐frequency NH 3 spikes spanning over a less than 1‐min duration were observed during the high traffic periods. The occurrence of the NH 3 spikes was closely correlated with observed CO 2 spikes, a good marker of traffic exhaust. This correlation yielded an NH 3 emission ratio of 0.12 ppbv/ppmv, which can be used to estimate an NH 3 emission factor of 35.5 mg/km. The [NH 3 ]/[CO 2 ] ratios over the entire field study was also obtained and added into the best NH 3 emission estimates. On a snowy day, no obvious drop of NH 3 and CO 2 concentrations was measured as the ambient H 2 O vapor increased. The observed dramatic decrease in the ambient NH 3 and CO 2 concentrations on a rainy day resulted from a quick air mass switch. Two similar bimodal diurnal patterns associated with the rush hour traffic were observed during school holidays and school days of Queens College, New York. More NH 3 emissions from cold start vehicles might contribute to a higher peak in the late afternoon hours. Such observations suggest that the NH 3 emissions from the traffic exhaust could be a major source of the ambient NH 3 in urban areas.
Electrochemical-acoustic time of flight: in operando correlation of physical dynamics with battery charge and health (2015)

Electrochemical-acoustic time of flight analysis for simple<italic>in operando</italic>determination of mechanical evolution, state-of-charge, and state-of-health of any closed battery.
Markers of Cell Proliferation and Expression of Melanosomal Antigen in Lymphangioleiomyomatosis (1999)

Pulmonary lymphangioleiomyomatosis (LAM), a disease of young women, is characterized by proliferation of immature-appearing smooth-muscle cells (LAM cells) in the lungs and abdomen. LAM cells react with monoclonal antibody HMB45, which recognizes a 100-kD glycoprotein (gp100) originally found in human melanoma cells. We investigated the expression and the subcellular localization of gp100 in lung tissue from patients with LAM and in human melanoma cell lines (Malme-3M, A2058, and CHL-1), and the relationship between this expression and cellular proliferation. Binding sites for HMB45 antibody in melanoma and LAM cells were located in cytoplasmic granules resembling immature melanosomes. LAM cells reactive for proliferating-cell nuclear antigen (PCNA), a marker of cellular proliferation, were spindle-shaped, in contrast to the large, epithelioid cells reacting with HMB45 antibody. In accord with this finding, we observed an inverse relationship between the immunostaining for HMB45 antibody and PCNA in LAM and melanoma cells. Thus, LAM and melanoma cells are heterogeneous with respect to their stages of proliferation and their expression of melanoma antigens. PCNA-positive cells, which are more likely to be negative for reactivity with HMB45 antibody, may be more relevant to the progression of LAM than are HMB45-positive cells, which are the hallmark of LAM.
Cascaded exciton energy transfer in a monolayer semiconductor lateral heterostructure assisted by surface plasmon polariton (2017)

Atomically thin lateral heterostructures based on transition metal dichalcogenides have recently been demonstrated. In monolayer transition metal dichalcogenides, exciton energy transfer is typically limited to a short range (~1 μm), and additional losses may be incurred at the interfacial regions of a lateral heterostructure. To overcome these challenges, here we experimentally implement a planar metal-oxide-semiconductor structure by placing a WS<sub>2</sub>/MoS<sub>2</sub> monolayer heterostructure on top of an Al<sub>2</sub>O<sub>3</sub>-capped Ag single-crystalline plate. We find that the exciton energy transfer range can be extended to tens of microns in the hybrid structure mediated by an exciton-surface plasmon polariton-exciton conversion mechanism, allowing cascaded exciton energy transfer from one transition metal dichalcogenides region supporting high-energy exciton resonance to a different transition metal dichalcogenides region in the lateral heterostructure with low-energy exciton resonance. The realized planar hybrid structure combines two-dimensional light-emitting materials with planar plasmonic waveguides and offers great potential for developing integrated photonic and plasmonic devices.Exciton energy transfer in monolayer transition metal dichalcogenides is limited to short distances. Here, Shi et al. fabricate a planar metal-oxide-semiconductor structure and show that exciton energy transfer can be extended to tens of microns, mediated by an exciton-surface-plasmon-polariton-exciton conversion mechanism.
Coated capillaries and additives for the separation of proteins by capillary zone electrophoresis and capillary isoelectric focusing. (1991)

Strategies reported for the separation of proteins in capillary zone electrophoresis and capillary isoelectric focusing are reviewed. The strategies are grouped into two categories: coated capillaries and buffer/sample additives. Success attained with each case and also, more importantly, the limitations of the methodology are discussed. Recent results from our own laboratory in the area of capillary isoelectric focusing in uncoated, fused silica capillaries using additives are summarized. The advantages and disadvantages of coated columns vs. additives are delineated.
Chiral Induction in the Ionothermal Synthesis of a 3-D Coordination Polymer (2007)

A new chiral coordination polymer, (BMIm)2[Ni(TMA-H)2(H2O)2], was prepared ionothermally from chiral ionic liquid. The use of l-aspartate as one component of the ionic liquid induces chirality in the resulting solid, despite the fact that the anion is not occluded by the material and that the solid itself is built from only nonchiral building blocks. Without the chiral component, an achiral compound is formed under the same synthesis conditions.
Overproduction of a low-affinity penicillin-binding protein and high-level ampicillin resistance in Enterococcus faecium (1994)

Five ampicillin-resistant clinical isolates of Enterococcus faecium were analyzed for a correlation between overproduction of the low-affinity penicillin-binding protein (PBP 5) and the level of ampicillin resistance. Comparison was made with one susceptible clinical isolate and its ampicillin-resistant derivative obtained in the laboratory by selection with increasing concentrations of penicillin. Overproduction of the low-affinity PBP relative to the susceptible isolate was noted in moderately resistant strains (MIC, 32 micrograms/ml) but not in highly resistant strains (MIC, 128 micrograms/ml). Polyclonal antibodies specifically reacting with the low-affinity PBP of Enterococcus hirae, Enterococcus faecalis, and Enterococcus faecium (M. Ligozzi, M. Aldegheri, S. C. Predari, and R. Fontana, FEMS Microbiol. Lett. 83:335-340, 1991) were used to determine the amount of this PBP in the E. faecium isolates. In all strains, the antibody preparation reacted with a membrane protein of the same molecular mass as PBP 5. The amount of this protein was very small in the susceptible strain but large in all of the resistant strains. These results suggest that the highly resistant strains also overproduced the low-affinity PBP, which, compared with PBP 5 of moderately resistant strains, appeared to be modified in its penicillin-binding capability.
Fatty acid abnormalities in hemodialysis patients: effect of L-carnitine administration. (1989)

Serum fatty acid profiles were determined using gas chromatography/mass spectrometry in three groups of subjects. Compared to normal controls, eight patients on maintenance hemodialysis had significantly lower proportions of linoleic (28.15 +/- 1.3 vs. 26.5 +/- 1.4%, P less than 0.003), linolenic (0.49 +/- 0.2 vs. 0.21 +/- 0.2%, P less than 0.04) and arachidonic acids (8.42 +/- 0.9 vs. 6.0 +/- 1.5%, P less than 0.0001). Dialysis patients also had higher proportions of oleic (8.9 +/- 1.8 vs. 15.3 +/- 3.5%, P less than 0.0001) and n-9 eicosatrienoic acids (0.26 +/- 0.2 vs. 0.54 +/- 0.3%, P less than 0.04). Ratios between oleic and arachidonic acid and between eicosatrienoic and arachidonic acids were also significantly higher in the dialysis group. In a separate group of either chronic dialysis patients, L-carnitine was given intravenously for a period of 6 to 18 months. In this group linoleic, linolenic and eicosatrienoic acids were not significantly different from normal controls. The ratio between eicosatrienoic and arachidonic acids was also similar to normal controls. However, arachidonic acid remained significantly lower and oleic acid significantly elevated in the carnitine group. The ratio of saturated to unsaturated fatty acid was higher in the untreated dialysis patients compared to L-carnitine treated patients (0.75 +/- 0.07 vs. 0.65 +/- 0.06, P less than 0.01). Significant abnormalities in distribution of fatty acids was seen in hemodialyzed patients. Thus preliminary data suggest significant depletion of essential fatty acids in dialysis patients which is partially corrected by treatment of patients with L-carnitine.
Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by α-cyano-4-hydroxycinnamate (<i>Short Communication</i>) (1974)

alpha-Cyano-4-hydroxycinnamate greatly inhibits the transport of pyruvate but not that of acetate or butyrate in liver mitochondria and erythrocytes. In the latter, lactate uptake is also inhibited. It is concluded that a specific carrier is involved in membrane transport of pyruvate and that the plasma-membrane carrier may also be involved in lactate transport.
Death mechanisms in cultured cells infected by Semliki Forest virus. (1997)

We have investigated the induction of cell death in cultured cells by the virulent SFV4 and avirulent A7 strains of Semliki Forest virus (SFV). In BHK cells, death occurred by a typical apoptotic mechanism, as did the death of oligodendrocytes in glial cell cultures. For cerebellar neuron cultures, virus-induced death was due to necrosis. Although the SFV4 and A7 strains did not differ in the mechanism of induction of cell death, the virulent SFV4 strain did multiply to a higher titre in cultured neurons than the avirulent A7 strain. This is consistent with previous animal studies which indicate that the virulence of SFV strains is controlled by rapidity of multiplication in the CNS, leading to a lethal threshold of damage, rather than differential cell tropism or cell death mechanisms. The immune-mediated demyelination induced by avirulent strains may be triggered by apoptosis of oligodendrocytes, the consequences of which are obscured by death for virulent strains.
Capturing CO{sub 2}: gas compression vs. liquefaction (2009)

Carbon capture and sequestration is very likely to be a key element of any future greenhouse gas legislation. Integrated gasification combined-cycle plants now under design have provisions to separation the CO{sub 2} at elevated pressures. Coal-fired plants have a far more difficult and expensive task - separating and compressing CO{sub 2} from pressures just above atmospheric conditions. 4 figs., 2 tabs.