gebhart/patrepeval huggingface dataset:
Countering Network-Centric Insider Threats through Self-Protective Autonomic Rule Generation (2012)

Insider threats are a growing problem in today's organizations. Detecting such attacks is especially challenging because most system owners and system administrators use networks to remotely manage the systems they are responsible for. In previous work, we introduced the Autonomic Violation Prevention System (AVPS) that has a scalable architecture to deal with such threats. This system uses low level human-specified and manually-entered rules to protect networked applications from disgruntled privileged users. However, rule-based systems are generally difficult to maintain when the number of rules is too large. This paper addresses this problem by allowing human beings to enter a smaller number of high-level rules that are automatically translated into one or more low-level rules based on an analysis of the incoming network traffic. The paper discusses how various high level rules (HLR) can detect new unwanted behaviors without any user intervention. Experiments conducted on three types of applications -- FTP, database, and Web -- show that the enhanced AVPS can detect known and unknown insider attacks through high level rules and process automation.
Relationship between structure and antiplaque and antimicrobial activities for a series of bispyridines (1983)

A series of bispyridines were examined for their bactericidal activities against in vitro, preformed, pure-culture plaques of selected oral plaque-forming bacteria. The antimicrobial activities of these agents were examined in relation to their molecular configurations. These studies demonstrated that the length of the interpyridine polymethylene group bridge and the length of the alkyl side chain were important determinants of antiplaque and antimicrobial efficacy. The most potent compounds of the bispyridine series were studied to determine the minimal conditions (concentration, duration, and frequency) of treatment required for likely clinical efficacy.
Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains (2011)

We propose that the in vivo functions of NM II (non-muscle myosin II) can be divided between those that depend on the N-terminal globular motor domain and those less dependent on motor activity but more dependent on the C-terminal domain. The former, being more dependent on the kinetic properties of NM II to translocate actin filaments, are less amenable to substitution by different NM II isoforms, whereas the in vivo functions of the latter, which involve the structural properties of NM II to cross-link actin filaments, are more amenable to substitution. In light of this hypothesis, we examine the ability of NM II-A, as well as a motor-compromised form of NM II-B, to replace NM II-B and rescue neuroepithelial cell-cell adhesion defects and hydrocephalus in the brain of NM II-B-depleted mice. We also examine the ability of NM II-B as well as chimaeric forms of NM II (II-A head and II-B tail and vice versa) to substitute for NM II-A in cell-cell adhesions in II-A-ablated mice. However, we also show that certain functions, such as neuronal cell migration in the developing brain and vascularization of the mouse embryo and placenta, specifically require NM II-B and II-A respectively.
Soft partitions lead to better learned ensembles (2003)

Ensembles of classifiers often provide better classification accuracy than a single classifier. One approach to creating ensembles is to create different subsets of the training data. We present a method of creating ensembles of classifiers by partitioning the dataset into regions using clustering. Learners are assigned to each region and the ensemble classification occurs by querying the learned classifier. The first strategy considered for partitioning the training set is to generate a hard, non-overlapping partition. This approach is shown to perform worse than a single classifier using the entire training set. However, the use of soft partitions significantly improves the overall ensemble performance. Three different methods of creating soft partitions are considered: a simple distance ratio, and both the fuzzy c-means and possibilistic c-means membership functions. All three methods are found to improve overall classifier performance beyond hard partitioning and often perform better than the base classifier using the entire training set. Experiments on six datasets illustrate the improved accuracy from creating ensembles on soft partitions of data.
Trends in AC/DC switching power supplies and DC/DC converters (2002)

A survey of key original equipment manufacturer (OEM) specifiers of power supplies reveals a number of changing power supply requirements. In particular, purchasers of AD/DC switchers are tending to add power factor correction and universal input voltages. There will be growing demand for 3.3 V outputs, and power requirements will generally move in a downward direction. DC/DC converter specifiers plan sharp increases in distributed power usage, and also expect to buy more high density, high frequency converters. Power rating will generally show an upward trend, along with more widespread demand for DC/DC converters with 3.3 V outputs for use in portable computers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MS-430, a Synthetic Pyrimidine Derivative, Influences the Intracellular Signal Transduction Pathway Leading to Neuronal Differentiation of PC12h Cells (1998)

Although NGF (nerve growth factor) induces neuronal differentiation of PC12 cells, EGF (epidermal growth factor) acts as a mitogen for these cells. We have studied the effects of a synthetic pyrimidine derivative, MS-430, on the NGF and EGF actions on PC12h cells. We found that MS-430 accelerated NGF-induced neurite extension of PC12h cells and that, in the presence of MS-430, PC12h cells extended neurites in response to EGF. Next, we investigated the tyrosine phosphorylation of NGF receptor TrkA and the EGF receptor (EGFR) as well as mitogen-activated protein kinase (MAPK), which is a key protein in the intracellular signal transduction pathway. It was found that MS-430 prolonged the EGF-induced phosphorylation of EGFR and MAPK compared to that without MS-430. MS-430 also prolonged the NGF-induced phosphorylation of MAPK, but the phosphorylation of TrkA induced by NGF was not affected by MS-430. These results suggest that MS-430 influences the intracellular signal transduction pathway which causes the neuronal differentiation of PC12h cells.
Segmentation using multiscale cues (2004)

Edges at multiple scales provide complementary grouping cues for image segmentation. These cues are reliable within different ranges. The larger the scale of an edge, the longer range the grouping cues it designates, and the greater impact it has on the final segmentation. A good segmentation respects grouping cues at each scale. These intuitions are formulated in a graph-theoretic framework where multiscale edges define pairwise pixel affinity at multiple grids, each captured in one graph. A novel criterion called average cuts of normalized affinity is proposed to evaluate a simultaneous segmentation through all these graphs. Its near-global optima can be solved efficiently. With a sparse yet complete characterization of pairwise pixel affinity, this graph-cuts approach leads to a hierarchy of coarse to fine segmentations that naturally take care of textured regions and weak contours.
The deformation prediction of mine slope surface using PSO-SVM model (2013)

Based on the main factors with important influence on thedeformation of the mine slope, a new methodintegrating support vector machine (SVM) and particleswarm optimization (PSO) was proposed to predict thedeformation of mine slope surface. Themeteorological factors and the deformation data of the research area are acquired using the advanced deformation monitoring equipment GroundBased-Synthetic Aperture Radar (GB-SAR).Then the SVM is used to predict the mine slope deformation. The PSO is employed to optimize the structure parameters of the SVM. The proposed newmethod was applied to predict the mine slope surface deformation of theAnjialing diggings in China. The obtained experiments results indicated thatthe proposed method can provide precise prediction of the mining slope surfacedeformation and its performance is superior to its rivals. DOI:  http://dx.doi.org/10.11591/telkomnika.v11i12.3732
A new method for frequency synthesis (2003)

A new method for constructing direct digital frequency synthesizers (DDFSs) and phase-locked loops (PLLs) is presented. The DDFSs and PLLs have a high frequency resolution, low spurious noise and high frequency-switching speed. The frequency resolution in mu Hz-range can be reached and at the same time the spurious noise is kept MHz apart from the carrier. The large spurious-noise-to-carrier distance makes it easy that the amplitude of the spurious noise be strongly attenuated and at the same time a short frequency-switching time of the DDFS and the PLL be kept.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Growth-related changes in specific mRNAs of cultured mouse cells. (1983)

A cDNA plasmid library has been constructed from the poly(A)+ RNA present in BALB/c3T3 cells after serum stimulation. Of 3,500 clones tested, approximately 0.5% contained inserts corresponding to mRNAs present at higher levels in serum-stimulated BALB/c 3T3 cell cultures than in quiescent cultures. Most of these RNA species increased 2- to 5-fold, and the kinetics of increase for various RNAs differed. One clone (28H6) hybridized to a 1-kilobase RNA species that is present at barely detectable levels in resting cells but is increased at least 15- to 20-fold after serum stimulation, reaching a maximal level coincident with the onset of DNA synthesis. This RNA was at a high level in proliferating cells but decreased rapidly as cells reached confluence. 28H6 RNA was also increased in resting cells infected with simian virus 40 or stimulated with platelet-derived growth factor.
Efforts Toward "An Ever Closer" European Union Confront Immigration Barriers (1996)

The single market envisioned by Treaty establishing Economic has evolved from limited focus on economic unity to greater goal of social and political unity. This change in focus is illustrated (at least symbolically) by evolution of name given to this collaboration which has changed from European Economic Community to European Community and most recently to European (EU) or the Union.1 But what is in a name? The EU is home to millions of non-EU nationals whose status in Union remains unclear. At minimum, there is an acknowledgment that free movement of (as opposed to just workers or citizens) is essential to achieve a single internal market.2 There can scarcely be any doubt that completion of internal market, which is ultimate purpose of Union, depends, in part, on creation of a common regime on a number of issues pertaining to non immigration and national rules and policies relating to [third-country nationals].3 Indeed this goal of free movement of is one of Four Freedoms guaranteed by Treaty on Union (EU Treaty).4 This paper will discuss some of developments and setbacks that continue to challenge formation of a truly united Union. Although EU Treaty provides for principle of free movement of persons, scope of this guarantee and manner of its implementation are matters on which Member States have yet to agree. Underlying disagreement is whether free movement of persons includes both EU and
Family Planning, Sexually Transmitted Diseases and Contraceptive Choice: A Literature Update--Part I (1992)

Willard Cates, Jr., Katherine M. Stone, Family Planning, Sexually Transmitted Diseases and Contraceptive Choice: A Literature Update--Part I, Family Planning Perspectives, Vol. 24, No. 2 (Mar. - Apr., 1992), pp. 75-84
Grating theory: new equations in Fourier space leading to fast converging results for TM polarization (2000)

Using theorems of Fourier factorization, a recent paper [J. Opt. Soc. Am. A 13, 1870 (1996)] has shown that the truncated Fourier series of products of discontinuous functions that were used in the differential theory of gratings during the past 30 years are not converging everywhere in TM polarization. They turn out to be converging everywhere only at the limit of infinitely low modulated gratings. We derive new truncated equations and implement them numerically. The computed efficiencies turn out to converge about as fast as in the TE-polarization case with respect to the number of Fourier harmonics used to represent the field. The fast convergence is observed on both metallic and dielectric gratings with sinusoidal, triangular, and lamellar profiles as well as with cylindrical and rectangular rods, and examples are shown on gratings with 100% modulation. The new formulation opens a new wide range of applications of the method, concerning not only gratings used in TM polarization but also conical diffraction, crossed gratings, three-dimensional problems, nonperiodic objects, rough surfaces, photonic band gaps, nonlinear optics, etc. The formulation also concerns the TE polarization case for a grating ruled on a magnetic material as well as gratings ruled on anisotropic materials. The method developed is applicable to any theory that requires the Fourier analysis of continuous products of discontinuous periodic functions; we propose to call it the fast Fourier factorization method.
Reservoir Model Information System: REMIS (2008)

We describe a novel data visualization framework named Reservoir Model Information System (REMIS) for the display of complex and multi-dimensional data sets in oil reservoirs. It is aimed at facilitating visual exploration and analysis of data sets as well as user collaboration in an easier way. Our framework consists of two main modules: the data access point module and the data visualization module. For the data access point module, the Phrase-Driven Grammar System (PDGS) is adopted for helping users facilitate the visualization of data. It integrates data source applications and external visualization tools and allows users to formulate data query and visualization descriptions by selecting graphical icons in a menu or on a map with step-by-step visual guidance. For the data visualization module, we implemented our first prototype of an interactive volume viewer named REMVR to classify and to visualize geo-spatial specific data sets. By combining PDGS and REMVR, REMIS assists users better in describing visualizations and exploring data so that they can easily find desired data and explore interesting or meaningful relationships including trends and exceptions in oil reservoir model data.
Viral infections of the heart (1993)

Characteristics of viruses inducing cardiac disease, G.B. Clements epidemiology of viral infections of the heart, D. Reid and N. Grist the histopathological features of acute myocarditis, M.E. Billingham clinical features of viral infections of the heart, P.J. Richardson and H. Why pathogenesis of disease - animal models, S.A. Huber experimental studies in viral infections of the heart, A. Matsumori pathogenesis of disease - humans, B. Maisch et al the role of HIV in cardiac disease, N.A. Boon and A.J. Jacob the role of cytomegalovirus in human atherosclerosis, J.L. Melnick the laboratory diagnosis of enterovirus-induced heart disease, R. Kandolf and P. Muir prospects of treatment and prevention of virally-induced heart disease, W. Al-Nakib.
Aminoglycoside resistance and aminoglycoside usage: ten years of experience in one hospital (1991)

For 10 years the 700-bed Minneapolis Veterans Affairs Medical Center has conducted a policy of carefully controlled aminoglycoside usage and monitoring of resistance of over 25,000 aerobic and facultative gram-negative bacillary isolates to the aminoglycosides. On two occasions during the 1980s, our experience of introducing amikacin at a high level of usage was associated with a significant reduction in resistance to gentamicin and tobramycin among gram-negative bacilli. Rapid reintroduction of gentamicin usage in 1982 after the first amikacin period was associated with a significant and rapid increase in gentamicin and tobramycin resistance. However, in 1986, gentamicin was again reintroduced to this institution at an initially modest level, and the percentage of usage of gentamicin was gradually increased over a 15-month period without a significant change in resistance to gentamicin, tobramycin, or amikacin while maintaining an overall 68% gentamicin usage and 30% amikacin usage. Aminoglycoside usage (measured as patient days) rose steadily from under 2,000 patient days per quarter in 1980 and 1981 to over 3,000 days per quarter in 1985. Since 1985, usage has declined to under 2,500 patient days per quarter in 1990. This usage rise and fall occurred during a steadily declining daily patient census that was 590 in 1980 and 465 in 1989. A move to a new hospital building in June 1988 was associated with an additional significant decline in resistance to all aminoglycosides (P less than 0.05), continuing a trend that was evident for the year preceding the move. Resistance to aminoglycoside antibiotics is now at the lowest level in 10 years at this institution, with only one gram-negative organism, Pseudomonas aeruginosa, that exhibits more than 5% resistance to gentamicin and no gram-negative species that are more than 5% resistant to amikacin and tobramycin.
Functional Analysis of the Human Cyclin D2 and Cyclin D3 Promoters (1996)

The D-type cyclins promote progression through the G1 phase of the cell cycle and may provide a link between growth factors and the cell cycle machinery. We determined the nucleotide sequence of the 5'-flanking region of the human cyclin D2 and cyclin D3 genes and identified the transcription start sites. Analysis of the upstream sequences required for transcription of the cyclin D2 and cyclin D3 genes in continuously dividing cells revealed marked differences in their regulatory elements. In the cyclin D2 gene positive elements were localized between positions -306 and -114 relative to the ATG codon at +1. Additional positive elements were localized between -444 and -345, whereas sequences that reduced transcription were identified between nucleotides -1624 and -892. In the cyclin D3 gene all of the positive elements required for maximal transcription were localized between nucleotides -366 and -167, and no negative elements were found. The activities of a reporter gene linked to the upstream regulatory sequences of the cyclin D2 gene but not the cyclin D3 gene were induced when starved cells were serum stimulated. This suggests that although the abundance of both the cyclin D2 and cyclin D3 mRNAs is increased by serum stimulation, only the cyclin D2 gene is up-regulated at the transcriptional level. Sequences between nucleotides -306 and -1624 of the cyclin D2 gene were necessary for serum inducibility.
Soluble Recombinant Coxsackievirus and Adenovirus Receptor Abrogates Coxsackievirus B3–Mediated Pancreatitis and Myocarditis in Mice (2004)

To our knowledge, CAR-Fc is the only protein that has been shown to block coxsackievirus infection of the pancreas. However, regardless of the efficacy of the test protein, target tissue cannot be rescued after day 3 of infection in the A/J mouse model.
A Safety Food Consumption Mobile System through Semantic Web Technology (2014)

Over 3,000 compounds are being added to processed food. These compounds have numerous effects on food: add color, stabilize, texturize, preserve, sweeten, thicken, add flavor, soften, emulsify, and so on. According to a recent report by the World Health Organization, governments have lately focused on legislation to reduce such ingredients or compounds in manufactured foods for they might have side effects causing health risks such as the heart disease, cancer, diabetes, allergens, obesity, etc. Safety in food consumption especially by patients of risk groups have become crucial for such health problems are in the top ten ranked health risks around the world. By supervising what and how much to eat as well as what not to eat, we can maximize a patient's life quality by avoiding unhealthy ingredients or compounds. In helping patients take control of their safe food consumption, we need smart personal e-health systems. Smart personal e-health systems with advanced knowledge management technology can provide suggestions of food appropriate for consumption by individuals. Accessing annotations in the ontology knowledgebase of food appropriate to their personal health condition can be provided. This article discusses one such software application, namely the Safety Food Consumption Mobile System, employing Semantic Web Technology.
Immunologic tolerance after oral administration of reovirus: requirement for two viral gene products for tolerance induction. (1981)

Abstract We have demonstrated that reovirus type 1, but not type 3, generates serotype-specific immunologic tolerance for DTH responses following oral administration of UV-inactivated virus. As shown by adoptive transfer experiments, the tolerance is secondary to the generation of viral-specific suppressor T cells that are present in spleen and mesenteric lymph nodes. No tolerance was generated when live virus was administered orally. Using recombinant viral clones, it was found that 2 viral gene products were required for tolerance induction; serotype specificity is a property of the viral hemagglutinin (the product of the S1 dsRNA segment). The inability of type 3 reovirus to induce suppression following oral administration is a property of the mu 1C polypeptide (the product of the M2 dsRNA genome segment).
Nondestructive testing of wire hoisting rope by magnetic analysis. (1926)

In an endeavor to meet the great need for a reliable nondestructive method for the testing of wire hoisting rope the Bureau of Standards has conducted an investigation of the possibilities of magnetic analysis for this purpose. The investigation has been of a fundamental nature, consisting in a study of the magnetic properties of steel wire of the kind used in the manufacture of wire rope and the effect on them of deterioration due to various causes. The effects of stress, wear, and fatigue were studied. While it is evident that there is a very close connection between the magnetic and mechanical properties of steel, the relationships are so complex that much more study will be needed before the results of magnetic tests can be interpreted with a sufficient degree of certainty to warrant their use as a practical method for the routine inspection of wire rope.
Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses (2013)

Neonates show an impaired anti-microbial host defence, but the underlying immune mechanisms are not understood fully. Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell subset characterized by their capacity to suppress T cell immunity. In this study we demonstrate that a distinct MDSC subset with a neutrophilic/granulocytic phenotype (Gr-MDSCs) is highly increased in cord blood compared to peripheral blood of children and adults. Functionally, cord blood isolated Gr-MDSCs suppressed T cell proliferation efficiently as well as T helper type 1 (Th1), Th2 and Th17 cytokine secretion. Beyond T cells, cord blood Gr-MDSCs controlled natural killer (NK) cell cytotoxicity in a cell contact-dependent manner. These studies establish neutrophilic Gr-MDSCs as a novel immunosuppressive cell subset that controls innate (NK) and adaptive (T cell) immune responses in neonates. Increased MDSC activity in cord blood might serve as key fetomaternal immunosuppressive mechanism impairing neonatal host defence. Gr-MDSCs in cord blood might therefore represent a therapeutic target in neonatal infections.