gebhart/patrepeval huggingface dataset:
Parameter estimation for SAR moving target detection using Fractional Fourier Transform (2014)

This paper proposes an algorithm for multi-channel SAR ground moving target detection and estimation using the Fractional Fourier Transform(FrFT). To detect the moving target with low speed, the clutter is first suppressed by Displace Phase Center Antenna(DPCA), then the signal-to-clutter can be enhanced. Have suppressed the clutter, the echo of moving target remains and can be regarded as a chirp signal whose parameters can be estimated by FrFT. FrFT, one of the most widely used tools to time-frequency analysis, is utilized to estimate the Doppler parameters, from which the moving parameters, including the velocity and the acceleration can be obtained. The effectiveness of the proposed method is validated by the simulation.
Semaphorin SEMA3F Has a Repulsing Activity on Breast Cancer Cells and Inhibits E-Cadherin-Mediated Cell Adhesion (2005)

Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular endothelial growth factor (VEGF) and SEMA3F antibodies. In vitro, SEMA3F inhibits cell spreading; this activity is opposed by VEGF. These results suggest that VEGF and SEMA3F compete for binding to their common neuropilin receptor. In the present report, we investigated the attractive/repulsive effects of SEMA3F on cell migration when cells were grown in a three-dimensional system and exposed to a SEMA3F gradient. In addition, we adapted the neurobiologic stripe assay to analyze the migration of tumor cells in response to SEMA3F. In the motile breast cancer cell line C100, which expresses both neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors, SEMA3F had a repulsive effect, which was blocked by anti-NRP2 antibody. In less motile MCF7 cells, which express only NRP1, SEMA3F inhibited cell contacts with loss of membrane-associated E-cadherin and beta-catenin without motility induction. Cell spreading and proliferation were reduced. These results support the concept that in a first step during tumorigenesis, normal tissues expressing SEMA3F would try to prevent tumor cells from spreading and attaching to the stroma for further implantation.
Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. (1986)

Patients with noninsulin-dependent diabetes mellitus (NIDDM) have both preprandial and postprandial hyperglycemia. To determine the mechanism responsible for the postprandial hyperglycemia, insulin secretion, insulin action, and the pattern of carbohydrate metabolism after glucose ingestion were assessed in patients with NIDDM and in matched nondiabetic subjects using the dual isotope and forearm catheterization techniques. Prior to meal ingestion, hepatic glucose release was increased (P less than 0.001) in the diabetic patients measured using [2-3H] or [3-3H] glucose. After meal ingestion, patients with NIDDM had excessive rates of systemic glucose entry (1,316 +/- 56 vs. 1,018 +/- 65 mg/kg X 7 h, P less than 0.01), primarily owing to a failure to suppress adequately endogenous glucose release (680 +/- 50 vs. 470 +/- 32 mg/kg X 7 h, P less than 0.01) from its high preprandial level. Despite impaired suppression of endogenous glucose production during a hyperinsulinemic glucose clamp (P less than 0.001) and decreased postprandial C-peptide response (P less than 0.05) in NIDDM, percent suppression of hepatic glucose release after oral glucose was comparable in the diabetic and nondiabetic subjects (45 +/- 3 vs. 39 +/- 2%). Although new glucose formation from meal-derived three-carbon precursors (53 +/- 3 vs. 40 +/- 7 mg/kg X 7 h, P less than 0.05) was greater in the diabetic patients, it accounted for only a minor part of this excessive postprandial hepatic glucose release. Postprandial hyperglycemia was exacerbated by the lack of an appropriate increase in glucose uptake whether measured isotopically or by forearm glucose uptake. Thus as has been proposed for fasting hyperglycemia, excessive hepatic glucose release and impaired glucose uptake are involved in the pathogenesis of postprandial hyperglycemia in patients with NIDDM.
Adjustable Measuring Crutch (1963)

Journal Article Adjustable Measuring Crutch Get access Theodore T. Tagawa Theodore T. Tagawa *Department of Physical Therapy, Los Angeles County General Hospital, Los Angeles, California. Search for other works by this author on: Oxford Academic Google Scholar Physical Therapy, Volume 43, Issue 2, February 1963, Pages 113–114, https://doi.org/10.1093/ptj/43.2.113 Published: 01 February 1963
Refactoring via Program Slicing and Sliding (2007)

This short paper is a summary of my doctoral research, which was conducted under Oege de Moor's supervision at the University of Oxford, starting October 2001. The thesis was submitted on September 29, 2006, and defended on January 18, 2007. The final version was submitted, after minor corrections, on June 15, 2007.
Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile (2014)

Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modification, and cocrystals exist, lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug. Among lipid based formulations, self-microemulsifying formulations (droplet size < 100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Various components that are used to formulate these dosage forms like surfactants and lipids contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be surmounted. The present paper gives exhaustive information on the formulation design and characterization of SMEDDS along with the probable mechanisms by which the bioavailability can be improved with SMEDDS.
The inhibition of prostaglandin E1-induced corneal neovascularization by steroid eye drops. (1989)

The antiangiogenic activity of several steroid eye drops was evaluated in a PGE-induced corneal neovascularization. Pred-Forte (1% prednisolone acetate) and Maxidex (0.1% dexamethasone) were very effective in preventing neovascularization. Medroxyprogesterone acetate at 0.1% in Tears Naturale was moderately effective and fluorometholone was less effective in blocking neovascularization. Cortisone alone was not very effective; however, the addition of heparin greatly enhanced its inhibitory effect. PGE1 induced corneal neovascularization and increased the leukocytes infiltration. The application of Maxidex right after the implantation of PGE1 pellet not only inhibited the leukocytes infiltration, but also blocked the neovascularization. These results suggested that the leukocytes infiltration might be one of the factors contributing to the development of neovascularization. The effect of steroid eye drops on the growth of preformed capillaries was also evaluated. The result demonstrated that Pred-Forte also suppressed the growth of well-developed capillaries.
Comparisons of Several Pixel-Level Image Fusion Schemes for Infrared and Visible Light Images (2006)

Image fusion provides a useful tool to integrate multiple images into a composite image that is more suitable for the purposes of human visual perception and can help us to extract more features. In this paper we compare the wavelets-based schemes which are based on ordinary wavelet transform, wavelet packet analysis and the nonlinear fusion scheme. It is concluded that the nonlinear fusion scheme has the best performance and more wavelet decomposition levels will give better results during the fusion process
Large‐Area Freestanding Graphene Paper for Superior Thermal Management (2014)

Large-area freestanding graphene papers (GPs) are fabricated by electrospray deposition integrated with a continuous roll-to-roll process. Upon mechanical compaction and thermal annealing, GPs can achieve a thermal conductivity of as high as 1238.3-1434 W m(-1) K(-1) . The super-thermally conductive GPs display an outstanding heat-spread ability and are more efficient in removing hot spots than Cu and Al foils.
A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing (2018)

Adeno-associated viral (AAV) vectors packaging the CRISPR-Cas9 system (AAV-CRISPR) can efficiently modify disease-relevant genes in somatic tissues with high efficiency. AAV vectors are a preferred delivery vehicle for tissue-directed gene therapy because of their ability to achieve sustained expression from largely non-integrating episomal genomes. However, for genome editizng applications, permanent expression of non-human proteins such as the bacterially derived Cas9 nuclease is undesirable. Methods are needed to achieve efficient genome editing <i>in vivo</i>, with controlled transient expression of CRISPR-Cas9. Here, we report a self-deleting AAV-CRISPR system that introduces insertion and deletion mutations into AAV episomes. We demonstrate that this system dramatically reduces the level of <i>Staphylococcus aureus</i> Cas9 protein, often greater than 79%, while achieving high rates of on-target editing in the liver. Off-target mutagenesis was not observed for the self-deleting Cas9 guide RNA at any of the predicted potential off-target sites examined. This system is efficient and versatile, as demonstrated by robust knockdown of liver-expressed proteins <i>in vivo</i>. This self-deleting AAV-CRISPR system is an important proof of concept that will help enable translation of liver-directed genome editing in humans.
Experimental laparoscopic aortic aneurysm resection and aortobifemoral bypass. (1996)

The purpose of the present study was to develop a technique for laparoscopic aortic aneurysm resection and aortobifemoral bypass through an anterior retroperitoneal approach. Eight piglets weighing between 75 and 80 kg were anesthetized. The concepts of Shumacker's anterior retroperitoneal exposure of the aorta were modified to allow laparoscopic exposure of the aorta in the first four animals. The other four animals were treated as if they had an aortic aneurysm. The piglet is placed in a supine position. The first port (1.5 cm) is placed laterally near the tip of the 12th rib. As much dissection of the retroperitoneum as possible is performed digitally through this port. A second port (1.5 cm), through which an abdominal lift device and a peritoneal retractor will be inserted, is created superiorly just lateral to the left rectus sheath, and a plane is developed that joins the original dissected space. Two other ports (1.5 cm) are placed in the flanks in a plane inferosuperior to the first port. The surgeon will use two of the lateral ports, and the third one is for the laparoscope. The last two ports (1.5 cm), from which the assistant will work, are placed in the left paramedian region. Using this approach, we performed four aortobifemoral bypasses in an average of 4.5 h after conventional i.v. heparinization (100 IU/kg) with minimal bleeding (blood loss < 550 cc). After infrarenal aortic cross-clamping, the external iliac and caudal vessels were either tied with 0-chromic or occluded with laparoscopic bull-dogs. The aorta was opened, and bleeding lumbar arteries and the aortoiliac junction were sutured with 4-0 Prolene. The vascular graft was sutured end-to-end to the aortic stump with running 4-0 Prolene. Tunneling to the femoral regions was made easy by the position of the animal. No mortality occurred before sacrifice of the animals. This laparoscopic animal model paves the way for human aortic aneurysm replacement.
Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events (2016)

Transforming growth factor (TGF)-β signaling disorder has emerged as a common molecular signature for aortic aneurysm development. The timing of postnatal maturation plays a key role in dictating the biological outcome of TGF-β signaling disorders in the aortic wall. In this study, we investigated the impact of deficiency of TGFβ receptors on the structural homeostasis of mature aortas. We used an inducible Cre-loxP system driven by a Myh11 promoter to delete Tgfbr1, Tgfbr2, or both in smooth muscle cells (SMCs) of adult mice. TGFBR1 deficiency resulted in rapid and severe aneurysmal degeneration, with 100% penetrance of ascending thoracic aortas, whereas TGFBR2 deletion only caused mild aortic pathology with low (26%) lesion prevalence. Removal of TGFBR2 attenuated the aortic pathology caused by TGFBR1 deletion and correlated with a reduction of early ERK phosphorylation. In addition, the production of angiotensin (Ang)-converting enzyme was upregulated in TGFBR1 deficient aortas at the early stage of aneurysmal degeneration. Inhibition of ERK phosphorylation or blockade of AngII type I receptor AT1R prevented aneurysmal degeneration of TGFBR1 deficient aortas. In conclusion, loss of SMC-Tgfbr1 triggers multiple deleterious pathways, including abnormal TGFBR2, ERK, and AngII/AT1R signals that disrupt aortic wall homeostasis to cause aortic aneurysm formation.
Device physics of TRAPATT oscillators (1970)

This paper utilizes a simplified physical model to describe TRAPATT (TRApped Plasma Avalanche Triggered Transit) operation. By yielding on computational accuracy, a complete high-efficiency device design is generated and the dependence of operation on physical parameters is elucidated. The extreme complexity of the precise differential equations describing TRAPATT operation has made the calculation of a single diode-circuit configuration a tour de force. However, by observing the important features of such a solution, a simplified approach giving realistic answers has been evolved. A theoretical device design has been evolved. This design provides device width and impurity density as a function of TRAPATT frequency, and indicates a decreasing degree of "reach through" with increasing frequency. In addition, the explicit dependence of width and impurity density on the diode's reverse saturation current has been obtained. The launching of the avalanche zone through the diode, and, in particular, the limitations implicit in the recovery to a swept-out state, are of broad significance in other types of diodes, particularly p-i-n switches and "snap" diodes.
Temperature-dependent magnetoresistance of magnetic tunnel junctions with ultraviolet light-assisted oxidized barriers (2001)

Co(10 nm)/AlO x ( nominally 2 nm)/Co(20 nm) tunnel junctions have been prepared under ultrahigh vacuum conditions applying a shadow mask technique. An ultraviolet light-assisted oxidation process of the AlOx barrier has been optimized by in situ x-ray photoelectron spectroscopy, in conjunction with temperature-dependent tunneling magnetoresistance measurements. Optimum-oxidized tunnel junctions show a magnetoresistance of 20% at 285 K, and up to 38% at 100 K. For under-oxidized samples, with a remaining Al layer between the Co bottom electrode and the AlOx barrier, the tunneling magnetoresistance decreases more rapidly with increasing temperature than observed for the over-oxidized samples. The resistance × area product of optimum-oxidized tunneling junctions exhibits a minimum, and increases for under- and over-oxidized samples.
Occlusion resistant object tracking (2002)

Object tracking with occlusion prediction using multiple feature correspondences is proposed. The tracking region is defined by a set of point features, tracked using Kanade-Lucas-Tomasi (1991) algorithm. During total occlusion the region position is estimated using motion prediction based on a Kalman filtering scheme applied to the motion model prior to occlusion. During partial occlusion the displacements of the occluded features are predicted based on the motion of the bounding box of the moving object. Experimental results on real and artificial images have shown that the algorithm behaves well under total and partial occlusion.
Guanaco management by pastoralists in the Southern Andes (2012)

As with most wild ungulates, guanacos (Lama guanicoe) overlap their range with domestic livestock resulting in a conflict for the use of rangelands between local livelihoods and conservation. This article explores a multiple-objective project that was set up in the La Payunia Provincial Reserve (Mendoza, Argentina) in order to address conservation of a migratory population of guanacos; desertification processes; and poverty alleviation. This study analyses the potential for guanaco use and management by a low-income Cooperative, the socio-economic impacts derived from the use, and the challenges facing the experience. The Cooperative Payún Matrú was formed in 2005 mainly by local goat herders with a subsistence economy, thus providing a unique example where the beneficiaries of guanaco use are a low-income community. The project was successful in articulating the agendas of several stakeholders. A model for guanaco use under high animal welfare standards was developed as well as an alternative source of income for local people. The case study illustrates how a conflict over the use of grassland between domestic livestock and a wild species could be turned into an opportunity for economic diversification for pastoralists. Lessons are drawn that could contribute to policy decisions as well as sustainable use programmes for other wildlife species.
Brain–computer interfaces: communication and restoration of movement in paralysis (2007)

The review describes the status of brain-computer or brain-machine interface research. We focus on non-invasive brain-computer interfaces (BCIs) and their clinical utility for direct brain communication in paralysis and motor restoration in stroke. A large gap between the promises of invasive animal and human BCI preparations and the clinical reality characterizes the literature: while intact monkeys learn to execute more or less complex upper limb movements with spike patterns from motor brain regions alone without concomitant peripheral motor activity usually after extensive training, clinical applications in human diseases such as amyotrophic lateral sclerosis and paralysis from stroke or spinal cord lesions show only limited success, with the exception of verbal communication in paralysed and locked-in patients. BCIs based on electroencephalographic potentials or oscillations are ready to undergo large clinical studies and commercial production as an adjunct or a major assisted communication device for paralysed and locked-in patients. However, attempts to train completely locked-in patients with BCI communication after entering the complete locked-in state with no remaining eye movement failed. We propose that a lack of contingencies between goal directed thoughts and intentions may be at the heart of this problem. Experiments with chronically curarized rats support our hypothesis; operant conditioning and voluntary control of autonomic physiological functions turned out to be impossible in this preparation. In addition to assisted communication, BCIs consisting of operant learning of EEG slow cortical potentials and sensorimotor rhythm were demonstrated to be successful in drug resistant focal epilepsy and attention deficit disorder. First studies of non-invasive BCIs using sensorimotor rhythm of the EEG and MEG in restoration of paralysed hand movements in chronic stroke and single cases of high spinal cord lesions show some promise, but need extensive evaluation in well-controlled experiments. Invasive BMIs based on neuronal spike patterns, local field potentials or electrocorticogram may constitute the strategy of choice in severe cases of stroke and spinal cord paralysis. Future directions of BCI research should include the regulation of brain metabolism and blood flow and electrical and magnetic stimulation of the human brain (invasive and non-invasive). A series of studies using BOLD response regulation with functional magnetic resonance imaging (fMRI) and near infrared spectroscopy demonstrated a tight correlation between voluntary changes in brain metabolism and behaviour.
Hydrostatic transmission systems (1969)

Hydrostatic transmission systems , Hydrostatic transmission systems , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Integration of metabolomics, lipidomics and clinical data using a machine learning method (2016)

We found lipidomics (Direct Infusion-Mass Spectrometry) data the most predictive for different dose responses. In addition, associations with the metabolic and lipidomic data with aspartate amino transaminase (AST), a hepatic leakage enzyme to assess organ damage, and albumin, indicative of altered liver synthetic function, were established. Furthermore, by establishing correlations and network connections between eicosanoids, phospholipids and triacylglycerols, we provide evidence that these lipids function as a key link between inflammatory processes and intermediary metabolism.
Phylogenetic and molecular characterization of a 23S rRNA gene positions the genus Campylobacter in the epsilon subdivision of the Proteobacteria and shows that the presence of transcribed spacers is common in Campylobacter spp (1994)

The nucleotide sequence of a 23S rRNA gene of Campylobacter coli VC167 was determined. The primary sequence of the C. coli 23S rRNA was deduced, and a secondary-structure model was constructed. Comparison with Escherichia coli 23S rRNA showed a major difference in the C. coli rRNA at approximately position 1170 (E. coli numbering) in the form of an extra sequence block approximately 147 bp long. PCR analysis of 31 other strains of C. coli and C. jejuni showed that 69% carried a transcribed spacer of either ca. 147 or ca. 37 bp. Comparison of all sequenced Campylobacter transcribed spacers showed that the Campylobacter inserts were related in sequence and percent G+C content. All Campylobacter strains carrying transcribed spacers in their 23S rRNA genes produced fragmented 23S rRNAs. Other strains which produced unfragmented 23S rRNAs did not appear to carry transcribed spacers at this position in their 23S rRNA genes. At the 1850 region (E. coli numbering), Campylobacter 23S rRNA displayed a base pairing signature most like that of the beta and gamma subdivisions of the class Proteobacteria, but in the 270 region, Campylobacter 23S rRNA displayed a helix signature which distinguished it from the alpha, beta, and gamma subdivisions. Phylogenetic analysis comparing C. coli VC167 23S rRNA and a C. jejuni TGH9011 (ATCC 43431) 23S rRNA with 53 other completely sequenced (eu)bacterial 23S rRNAs showed that the two campylobacters form a sister group to the alpha, beta, and gamma proteobacterial 23S rRNAs, a positioning consistent with the idea that the genus Campylobacter belongs to the epsilon subdivision of the class Proteobacteria.