gebhart/patrepeval huggingface dataset:
Ionic conductivity of polymer complexes formed by poly(β-propiolactone) and lithium perchlorate (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonic conductivity of polymer complexes formed by poly(β-propiolactone) and lithium perchlorateMasayoshi Watanabe, Makiko Togo, Kohei Sanui, Naoya Ogata, Tadahiko Kobayashi, and Zentaro OhtakiCite this: Macromolecules 1984, 17, 12, 2908–2912Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ma00142a079https://doi.org/10.1021/ma00142a079research-articleACS PublicationsRequest reuse permissionsArticle Views438Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interleukin‐4 Up‐Regulates T‐Tropic Human Immunodeficiency Virus Type 1 Transcription in Primary CD4<sup>+</sup> CD38<sup>+</sup> T‐Lymphocyte Subset (2005)

The capacity of human immunodeficiency virus type 1 (HIV-1) to infect resting cells and to produce progeny particles may contribute significantly to its pathogenicity in vivo. We previously reported that primary culture of resting CD4(+) CD38(+) T-lymphocyte subset had higher production rate of CXCR4-using (X4) HIV-1 than CD4(+) CD38(-) subset. Interleukin (IL)-4 highly contributed to the up-regulation of the X4 virus production in the CD38(+) subset. Here, we show evidences that IL-4 treatment of both resting CD38(+) and CD38(-) subsets allowed the adsorption, entry, and integration of X4 virus at similar rates, while the following viral transcription rate was significantly lower in the CD38(-) than CD38(+) subset. Treatment of the CD38 subsets with IL-4 or phytohemagglutinin revealed no association of X4 virus replication ability in the subsets with classic T-cell activation or proliferation. Interestingly, the activator protein (AP)-1 was significantly activated in the CD38(+) subset after IL-4 treatment, while both nuclear factor (NF)-kappaB and signal transducers and activator of transcription (STAT)-6 were activated in the IL-4-treated CD38(-) and CD38(-) subsets at similar levels. Thus, IL-4-dependent X4 HIV-1 transcription occurs efficiently in the CD38(+) but not CD38(-) subset of CD4(+) population and AP-1 could play a significant role on viral transcription, leading to the up-regulated X4 virus production in the CD38(+) subset.
Development of a high specific power sodium sulfur cell (2002)

The purpose of this R&D program is to explore the high-power capabilities of Na/S flat plate cells by testing standard cylindrical cells with active bases (only) at high rates under steady loads, and to utilize this data to support a proof of concept (POC) flat plate cell design. Typically, the test cells were discharged continuously to a specified depth of discharge (DOD) at a constant rate between 0.1 to 1.4 A/cm/sup 2/ in successive steps of 0.1 A/cm/sup 2/. The methods of determining the ohmic and polarization contributions are described. As part of the cell development activity, 113 mm thick beta" alumina membranes were tape cast and blanked to a 5 cm diameter, as sized by radial stress limitations. On the basis of test data and component engineering and evaluation, a 3.5 Ah (theoretical) POC cell design has emerged for high-power applications. In a logical extension of the POC cell, a conceptual design of a bipolar cell stack arrangement was predicted to achieve a power performance of 613 W/kg and 1.65 kW/L.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
BEAMS AND GIRDERS WITH CORRUGATED WEBS. IN: STRUCTURAL STABILITY RESEARCH COUNCIL. 1990 ANNUAL TECHNICAL SESSION, STABILITY OF BRIDGES, ST. LOUIS, MISSOURI, APRIL 10-11, 1990 (1990)

This paper offers a brief summary of the state-of-the-art regarding research and development in the area of beams and girders with corrugated webs. Most of the research and all of the developments have taken place outside the U.S. Corrugated webs offer many advantages, and with the developments in welding technology, there is a good incentive for making them in the U.S. Also described are a comprehansive plan of a research program at the University of Maine and pilot tests currently in progress.
Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain (2004)

To identify previously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic screen in Xenopus extracts. One class of inhibitors, termed ubistatins, blocked cell cycle progression by inhibiting cyclin B proteolysis and inhibited degradation of ubiquitinated Sic1 by purified proteasomes. Ubistatins blocked the binding of ubiquitinated substrates to the proteasome by targeting the ubiquitin-ubiquitin interface of Lys(48)-linked chains. The same interface is recognized by ubiquitin-chain receptors of the proteasome, indicating that ubistatins act by disrupting a critical protein-protein interaction in the ubiquitin-proteasome system.
A Mutation in the Schizosaccharomyces pombe rae1 Gene Causes Defects in Poly(A)+ RNA Export and in the Cytoskeleton (1995)

A collection of fission yeast Schizosaccharomyces pombe conditional mutants was screened for defective nucleocytoplasmic transport of poly(A)+ RNA by fluorescence in situ hybridization. We identified a temperature-sensitive mutant that accumulated poly(A)+ RNA in the nucleus and have named it rae1-1, for ribonucleic acid export. All rae1-1 cells exhibit the defect in poly(A)+ RNA export within 30 min following a shift to the non-permissive temperature. In addition, in the rae1-1 mutant, actin and tubulin become disorganized, and cells undergo an irreversible cycle arrest. Results from experiments in which rae1-1 cells were arrested in various phases of the cell division cycle and then shifted to nonpermissive temperature suggest that cells are particularly vulnerable to loss of rae1 function during G2/M. However, the inability to export RNA from the nucleus to the cytoplasm was not limited to a particular phase of the cell division cycle. The rae1 gene was isolated by complementation and encodes a predicted protein of 352 amino acids with four beta-transducin/WD40 repeats.
Tracking cancer drugs in living cells by thermal profiling of the proteome (2014)

The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of more than 7000 proteins in human cells by means of mass spectrometry. Monitoring the effects of small-molecule ligands on the profiles delineated more than 50 targets for the kinase inhibitor staurosporine. We identified the heme biosynthesis enzyme ferrochelatase as a target of kinase inhibitors and suggest that its inhibition causes the phototoxicity observed with vemurafenib and alectinib. Thermal shifts were also observed for downstream effectors of drug treatment. In live cells, dasatinib induced shifts in BCR-ABL pathway proteins, including CRK/CRKL. Thermal proteome profiling provides an unbiased measure of drug-target engagement and facilitates identification of markers for drug efficacy and toxicity.
Apparent and Real Distribution in GPC (Experiments with PMMA Samples) (1971)

Abstract Molecular weight distribution curves obtained by GPC are broadened if concentration and flow rate are fixed in the usual range. Therefore, the apparent nonuniformity U app of the samples is larger than the real non-uniformity U = (Mw/Mn) −1. For a number of fractionated and unfractionated samples of polymethyl methacrylate we determined M n and M w by osmotic, light-scattering, and viscosity measurements. Thus, the real value of U can be compared to U app obtained by GPC at different concentrations and flow rates, υ. The excess nonuniformity U exc is evaluated as function of concentration c, polydispersity, molecular weight, and flow rate. For c = 0 and υ = 0, U exc is not far from zero. For standard conditions one certain value of the excess standard deviation of the elution volume allow calculation of U exc for narrow and broader distributions and the obtaining of nearly correct values for the real nonuniformity U.
Cloning of restriction fragments of DNA from staphylococcal bacteriophage phi 11 (1981)

EcoRI fragments of Staphylococcus aureus bacteriophage phi 11 DNA were cloned in vector plasmid pSA2100 in S. aureus. The clones were analyzed in marker rescue experiments with suppressor- and temperature-sensitive mutants of phi 11 to correlate the genetic and physical map. Several mutants could be identified on the physical map, and a clone containing fragment EcoRI-B of phi 11 DNA expressed immunity to phage infection. In addition, it was found that recombinant plasmids containing phi 11 DNA sequences can be transferred by high-frequency transduction after phage phi 11 infection of host cells.
Ferroelectric Domain Morphology Evolution and Octahedral Tilting in Lead‐Free (Bi <sub>1/2</sub> Na <sub>1/2</sub> )TiO <sub>3</sub> –(Bi <sub>1/2</sub> K <sub>1/2</sub> )TiO <sub>3</sub> –(Bi <sub>1/2</sub> Li <sub>1/2</sub> )TiO <sub>3</sub> –BaTiO <sub>3</sub> Ceramics at Different Temperatures (2008)

Observations by in situ transmission electron microscopy (TEM) reveal the changes in domains morphology in 0.885(Bi 1/2 Na 1/2 )TiO 3 –0.05(Bi 1/2 K 1/2 )TiO 3 –0.015(Bi 1/2 Li 1/2 )TiO 3 –0.05BaTiO 3 ceramics. Evolution of the macroscopic ferroelectric domains has been observed at 25°–180°C. The ferroelectric domains and their walls reduce progressively with increasing temperature. In the selected‐area electron diffraction patterns, the crystallographic evidence of antiferroelectric domain is not found over the temperature range, which provides the evidence that the ferroelectric–antiferroelectric transition does not occur in the ceramic. The temperature‐dependent forbidden 3/2 1/2 0 and superstructure 3/2 1/2 1/2 reflections indicate the presence of an in‐phase and anti‐phase octahedral tilting in the ceramic, respectively. Dark‐field TEM images show that the size of the octahedral tilted domains is smaller than 30 nm across and that these domains are uniformly distributed in the grains. The influence of the localized octahedral titling on the stability of ferroelectric domains and the temperature‐dependent properties is discussed in this paper.
Extension of battery life via charge equalization control (1993)

The primary difficulty in charging storage batteries is in attaining process regulation that allows fast charging while avoiding destructive overcharging. A two-level approach to controlling the charging process is presented. A general background discussion of batteries and charging problems is followed by the presentation of a novel recirculating charge equalization technique that enhances the uniformity of batteries made up from long serial strings of cells. A straightforward means of embedding equalization within an outer-loop supervisory control that maintains a fast charging rate while providing overall protection against overcharging is briefly described. Simulation and experimental results confirm the applicability of the equalization control technique.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automatic CCTV surveillance-towards the VIRTUAL GUARD (2003)

The VIRTUAL GUARD is a general-purpose computer-based CCTV surveillance system for detecting potential criminal activity in public areas. The system monitors all activity in the surveillance area, the vast majority of which is people innocently going about their normal business. It will alarm when the observed activities of particular pedestrians and vehicles match any of the pre-defined suspicious behaviour criteria programmed into the system. At the same time as analysing movement behaviour, the system uses computer-controlled pan tilt zoom (PTZ) cameras to obtain close-up video recordings of any pedestrians and vehicles at the scene. The system can provide automatic surveillance in many different situations, from parking areas and commercial districts, to housing, recreational and transport facilities. It is particularly suited to the protection of government or commercial buildings located on city streets or other public areas where it is not possible to install perimeter fences.
Tunable Sub-Terahertz Wave Generation from an Organic DAST Crystal (2005)

Tunable sub-terahertz (THz) waves ranging from 0.3 to 3 THz were generated in a 4'- N , N -dimethylamino- N '-methyl-4-stilbazolium tosylate (DAST) crystal using the difference frequency mixing technique. We developed a dual-wavelength optical parametric oscillator near 990 nm with two KTiOPO 4 crystals as the input light source. The maximum output energy of 17 nJ/pulse (peak power: 1.4 W) was achieved at 0.7 THz using a high-quality DAST crystal with a 2-mm thickness.
A New Class of Antibody–Drug Conjugates with Potent DNA Alkylating Activity (2016)

The promise of tumor-selective delivery of cytotoxic agents in the form of antibody-drug conjugates (ADC) has now been realized, evidenced by the approval of two ADCs, both of which incorporate highly cytotoxic tubulin-interacting agents, for cancer therapy. An ongoing challenge remains in identifying potent agents with alternative mechanisms of cell killing that can provide ADCs with high therapeutic indices and favorable tolerability. Here, we describe the development of a new class of potent DNA alkylating agents that meets these objectives. Through chemical design, we changed the mechanism of action of our novel DNA cross-linking agent to a monofunctional DNA alkylator. This modification, coupled with linker optimization, generated ADCs that were well tolerated in mice and demonstrated robust antitumor activity in multiple tumor models at doses 1.5% to 3.5% of maximally tolerated levels. These properties underscore the considerable potential of these purpose-created, unique DNA-interacting conjugates for broadening the clinical application of ADC technology. Mol Cancer Ther; 15(8); 1870-8. ©2016 AACR.
Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes (2006)

Senescence may contribute to the pathogenesis of atherosclerosis. Although the bioavailability of nitric oxide (NO) is limited in senescence, the effect of NO on senescence and its relationship to cardiovascular risk factors have not been investigated fully. We studied these factors by investigating senescence-associated beta-galactosidase (SA-beta-gal) and human telomerase activity in human umbilical venous endothelial cells (HUVECs). Treatment with NO donor (Z)-1-[2-(2-aminoethyl)-N-(2-aminoethyl)amino]diazen-1-ium-1,2-diolate (DETA-NO) and transfection with endothelial NO synthase (eNOS) into HUVECs each decreased the number of SA-beta-gal positive cells and increased telomerase activity. The NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) abolished the effect of eNOS transfection. The physiological concentration of 17beta-estradiol activated hTERT, decreased SA-beta-gal-positive cells, and caused cell proliferation. However, ICI 182780, an estrogen receptor-specific antagonist, and L-NAME each inhibited these effects. Finally, we investigated the effect of NO bioavailability on high glucose-promoted cellular senescence of HUVECs. Inhibition by eNOS transfection of this cellular senescence under high glucose conditions was less pronounced. Treatment with L-arginine or L-citrulline of eNOS-transfected cells partially inhibited, and combination of L-arginine and L-citrulline with antioxidants strongly prevented, high glucose-induced cellular senescence. These data demonstrate that NO can prevent endothelial senescence, thereby contributing to the anti-senile action of estrogen. The ingestion of NO-boosting substances, including L-arginine, L-citrulline, and antioxidants, can delay endothelial senescence under high glucose. We suggest that the delay in endothelial senescence through NO and/or eNOS activation may have clinical utility in the treatment of atherosclerosis in the elderly.
Still under question the studio for the city (1996)

If Rupert Murdoch thought that his Fox studio would be wholeheartedly welcomed by the film industry, by Sydney, and by Australia, he must be feeling more than a little disappointed. A year and a half since the announcement that Twentieth Century Fox would establish a studio on the Royal Agricultural Society Showground site at Moore Park, many months after the initial release of the proposal details, and well after the terms of the final contract have been revealed, a heated debate on the political process involved in the decision is still bubbling away. Residents of Sydney's Moore Park/Paddington area are determined to continue their active campaign against the location, and, while the film industry has been relatively enthusiastic if not particularly voluble in its support, several influential industry groups are still concerned about the proposal, and are lobbying strongly for local content requirements to be written into the formal contract. A whole range of issues to do with the studio itself, with industry politics, with the non-transparency of the decision-making process, and with the basic rights of the citizens of Sydney have come to bear in a debate that just won't go away.
The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters. (2008)

In pancreatic ductal adenocarcinoma, TIMP-2 may have a more crucial role in prognosis than MMP-2, MMP-9 or angiogenesis. In ampullary adenocarcinoma, MMP-2 expression correlated with MVD, supporting its postulated role in angiogenesis.
Dodick laser phacolysis: thermal effects (1999)

This initial in vitro study demonstrates that the well-known risk of the tissue heating (i.e., phaco burn) does not occur with Dodick laser phacolysis, even when the irrigation flow is slow or discontinued.
After Dolly, a Pharming Frenzy (1998)

CLONINGBOSTON-- New successes in using DNA from fetal cells to clone transgenic animals have galvanized efforts to create transgenic livestock that will act as living factories, producing pharmaceutical products in their milk for treating human diseases and, perhaps, organs for transplantation. In the year since the announcement of Dolly's birth, a dozen other groups have been adapting the technique used by the team in Scotland. But a crucial difference between these experiments and the original Dolly breakthrough remains: Dolly was cloned from adult cells, but the later experiments all use nuclei from fetal cells. Indeed, so far the Dolly experiment has not been exactly replicated, and some scientists have even questioned whether Dolly is in fact the clone of an adult (see [sidebar][1], letter on p. [635][2]).

 [1]: http://www.sciencemag.org/cgi/content/short/279/5351/647
 [2]: http://www.sciencemag.org/cgi/content/full/279/5351/635c
High Concordance of Gene Methylation in Post-Digital Rectal Examination and Post-Biopsy Urine Samples for Prostate Cancer Detection (2006)

Gene analysis using conventional methylation specific polymerase chain reaction is a reliable method for detecting abnormal DNA methylation in voided urine samples obtained following digital rectal examination or prostate needle biopsy. The concordance between post-digital rectal examination and post-biopsy urinary samples for promoter methylation is high (82% to 94%), suggesting that urine collected after digital rectal examination may be used for genetic analysis with results similar to those in post-biopsy urine samples.
Permanent magnet trap for cold atoms (1995)

We report the trapping of neutral atoms in a permanent magnet trap. Approximately 1\ifmmode\times\else\texttimes\fi{}${10}^{8}$ ground-state lithium atoms have been confined in a nonzero magnetic-field minimum produced by six permanent magnets in an Ioffe configuration. These atoms have a kinetic temperature of 1.1 mK and a peak density of approximately 3\ifmmode\times\else\texttimes\fi{}${10}^{9}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}3}$. The trapped-atom lifetime is 240 s, limited by collisions with background gas. This trap provides an environment in which quantum-statistical effects, atomic collisions, and other ultralow-temperature phenomena can be studied.
Glucose Oxidation by Modified Mould Mycelium (1984)

Abstract A new strain of Aspergillus niger containing a high intracellular glucose oxidase and catalase activity could be isolated. The glucose oxidase of this strain showed some favourable properties with regard to enzymatic glucose oxidation in industrial scale. The mycelium was permeabilized by treatment with iso‐propanol. Then, additional catalase was bound to the mycelium so that a coimmobilizate, resulted. The enzymatic characteristics of this coimmobilizate, as compared with former immobilized glucose oxidase/catalase preparations, showed higher temperature stability and lower K m ‐value for glucose. Some basic trials were done for glucose oxidation in a stirred tank reactor where oxygen supply was carried out by controlled addition of hydrogen peroxide instead of conventional aeration. The influence of temperature on the stability of both, glucose oxidase and catalase, was investigated under these application conditions.
Temperature compensated permanent magnet YIG tuned oscillators (2002)

Advantages, disadvantages, and areas of concern regarding the use of a permanent magnet to provide the magnetic bias field for YIG tuned oscillators are discussed. Two different types of permanent-magnet YIG tuned oscillators with a temperature variation of less than 15 PPM/ degrees C were constructed. The measured characteristics of some of these devices are presented. The permanent magnets, when stabilized, show no deterioration of strength due to aging or repeated electrical and mechanical demagnetization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Alias-Free Shadow Maps using Graphics Hardware (2007)

The alias-free shadow maps technique is the first shadow map-based algorithm that computes shadows at floating-point accuracy and handles transparent surfaces elegantly. However, its major disadvantage is that it is a specialized software rendering technique, because shadow computations are performed by using irregular sampling point locations. We present a new algorithm that inherits the strengths of alias-free shadow maps and has an efficient hardware-accelerated implementation. With our method, the sampling points are transformed into multiple layers of regular pixel boundaries with a point sprite rendering technique, and the rasterized geometry is modified to include the necessary information for computing accurate shadow terms. We also present novel acceleration techniques and propose a few hardware modifications to enable real-time implementations.