gebhart/patrepeval huggingface dataset:
Evaluation of intraocular lens power calculation formulas in the triple procedure (1996)

Purpose: To determine whether the choice of intraocular lens (IOL) power formula improves IOL power predictions and whether personalized constants within the IOL power formula are critical factors in improving refractive predictions after combined penetrating keratoplasty, cataract extraction, and IOL implantation. Methods: Records of 46 patients who had the triple procedure between January 1988 and December 1992 were evaluated using the SRK II, SRK/T, Holladay, and Hoffer Q formulas to predict the postoperative spherical equivalent refractions for implanted lens power. Calculations were carried out with and without the use of personalized constants. The predictive accuracy of each formula was assessed by comparing the actual postoperative spherical equivalent refractive error with that predicted by the formulas. The predictive error and the distribution of predictive errors were used to assess predictive accuracy. Results: There was no difference in the mean absolute predictive errors and the distribution of predictive errors for the four formulas evaluated (P < .05). The use of personalized formula constants significantly reduced the mean absolute predictive error for the SRK II, SRK/T, and Holladay formulas (P < .05) and approached significance for the Hoffer Q formula. Conclusion: The findings suggest that the choice of IOL power formula does not affect IOL power predictions in the corneal triple procedure; however, personalized constants within a formula appears to be a critical factor in improving postoperative refractive predictions.
Valosin-Containing Protein (VCP/p97) Is Required for Poliovirus Replication and Is Involved in Cellular Protein Secretion Pathway in Poliovirus Infection (2012)

Poliovirus (PV) modifies membrane-trafficking machinery in host cells for its viral RNA replication. To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. In this study, we performed small interfering RNA (siRNA) screening targeting membrane-trafficking genes for host factors required for PV replication. We identified valosin-containing protein (VCP/p97) as a host factor of PV replication required after viral protein synthesis, and its ATPase activity was essential for PV replication. VCP colocalized with viral proteins 2BC/2C and 3AB/3B in PV-infected cells and showed an interaction with 2BC and 3AB but not with 2C and 3A. Knockdown of VCP did not suppress the replication of coxsackievirus B3 or Aichi virus. A VCP-knockdown-resistant PV mutant had an A4881G (a mutation of E253G in 2C) mutation, which is known as a determinant of a secretion inhibition-negative phenotype. However, knockdown of VCP did not affect the inhibition of cellular protein secretion caused by overexpression of each individual viral protein. These results suggested that VCP is a host factor required for viral RNA replication of PV among membrane-trafficking proteins and provides a novel link between cellular protein secretion and viral RNA replication.
The pathogenesis of pterygia (1999)

Pterygium is an active, invasive, inflammatory process, a key feature of which is focal limbal failure. In a two-stage process, “conjunctivalization” of the cornea occurs with tissue characterized by extensive chronic inflammation, cellular proliferation, connective tissue remodeling, and angiogenesis. An understanding of this process has resulted in efforts aimed at limbal reconstruction, which is considered the gold standard for surgical care. Although good results have been obtained with other treatment methods, a long-term approach to follow-up with at least 5-year survival figures is desirable. Sophisticated analyses of the tear film and surface epithelium in patients with pterygium may help explain symptoms. The efficacy, at least in the short term, of nonsteroidal anti-inflammatory drugs in the treatment of inflamed pterygia has been confirmed. Corneal topographic analysis has shown that surgery reduces induced astigmatism and also causes subtle changes that may explain postsurgical improvements in vision.
Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-<i>d</i>]pyrimidine scaffold (2018)

An efficient synthesis of substituted pyrido[2,3-d]pyrimidines was carried out and evaluated for in vitro anticancer activity against five cancer cell lines, namely hepatic cancer (HepG-2), prostate cancer (PC-3), colon cancer (HCT-116), breast cancer (MCF-7), and lung cancer (A-549) cell lines. Regarding HepG-2, PC-3, HCT-116 cancer cell lines, 7-(4-chlorophenyl)-2-(3-methyl-5-oxo-2,3-dihydro-1H-pyrazol-1-yl)-5-(p-tolyl)- pyrido[2,3-d]pyrimidin-4(3H)-one (5a) exhibited strong, more potent anticancer (IC<sub>50</sub>: 0.3, 6.6 and 7 µM) relative to the standard doxorubicin (IC<sub>50</sub>: 0.6, 6.8 and 12.8 µM), respectively. Kinase inhibitory assessment of 5a showed promising inhibitory activity against three kinases namely PDGFR β, EGFR, and CDK4/cyclin D1 at two concentrations 50 and 100 µM in single measurements. Further, a molecular docking study for compound 5a was performed to verify the binding mode towards the EGFR and CDK4/cyclin D1 kinases.
The Raman Scattering of Uranyl and Transuranium V, VI, and VII Ions (1974)

The Raman scattering of U(VI), Np(VI), Pu(VI), Am(VI), and Np(V), Am(V) in HClO 4 solutions and Np(VII) in a NaOH medium is reported. Direct observation of the polarized ν 1 vibration (D ∞h symmetry) is observed for the transuranium MO 2 n+ ions in the V and VI oxidation states. The spectroscopic evidence is consistent with a linear MO 2 n+ structure for the Np(VII) ion in basic solutions. The trend of the ν 1 frequency and the MO stretching force constants with the oxidation is discussed and is correlated with the bond strengths and the stability of the MO 2 n+ ions.
Developing Better Critical Paths in Healthcare (1998)

Critical paths are tools to manage healthcare delivery and ensure favorable patient outcomes. Unfortunately, many of these paths are not evaluated or revised after their initial development. One potential problem faced by nursing managers is that critical paths may lose relevance in a rapidly changing healthcare environment. The authors suggest one strategy to strengthen existing critical paths in a way that is responsive to these changes.
Radiation-induced reactive oxygen species formation prior to oxidative DNA damage in human peripheral T cells (2003)

Previously, we demonstrated that human peripheral T lymphocytes revealed early apoptotic changes (annexin V-positive) and late apoptotic changes (propidium iodide-positive), at 13 and 24 h, respectively, after irradiation of 5 Gy. Changes in mitochondrial membrane potential were observed at 10 h after irradiation of 5 Gy. Subsequently, mitochondrial cytochrome c-release was confirmed. In order to elucidate the mechanism which acts prior to the mitochondrial membrane potential changes, we examined in the previous study the radiation dose and the timing of oxidative DNA damage induced in human peripheral T lymphocytes following 10 MV X-ray irradiation. As a result, the production of 8-oxoguanine, i.e., the product of oxidative DNA damage, was clearly identified starting at 10, 6, and 3 h, after 2, 5, and 20 Gy of irradiation, respectively. Therefore, we examined in the present study reactive oxygen species (ROS) formation in T lymphocytes following 5 Gy of irradiation. Using a CCD camera system, we monitored fluorescence in T lymphocytes loaded with the succinimidyl ester of dichlorodihydrofluorescein diacetate (H2DCFDA), which is non-fluorescent until oxidized by ROS. We found that ROS formation occurred immediately after irradiation, continued for several hours, and resulted in oxidative DNA damage. Therefore, the origin of hyper-radiosensitivity of T lymphocytes seemed to be the high production of ROS in the mitochondrial DNA following irradiation.
Grid Integration of Wind Farms (2003)

Abstract This article gives an overview of grid integration of wind farms with respect to impact on voltage quality and power system stability. The recommended procedure for assessing the impact of wind turbines on voltage quality in distribution grids is presented. The procedure uses the power quality characteristic data of wind turbines to determine the impact on slow voltage variations, flicker, voltage dips and harmonics. The detailed assessment allows for substantially more wind power in distribution grids compared with previously used rule‐of‐thumb guidelines. Power system stability is a concern in conjunction with large wind farms or very weak grids. Assessment requires the use of power system simulation tools, and wind farm models for inclusion in such tools are presently being developed. A fixed‐speed wind turbine model is described. The model may be considered a good starting point for development of more advanced models, hereunder the concept of variable‐speed wind turbines with a doubly fed induction generator is briefly explained. The use of dynamic wind farm models as part of power system simulation tools allows for detailed studies and development of innovative grid integration techniques. It is demonstrated that the use of reactive compensation may relax the short‐term voltage stability limit and allow integration of significantly more wind power, and that application of automatic generation control technology may be an efficient means to circumvent thermal transmission capacity constraints. The continuous development of analysis tools and technology for cost‐effective and secure grid integration is an important aid to ensure the increasing use of wind energy. A key factor for success, however, is the communication of results and gained experience, and in this regard it is hoped that this article may contribute. Copyright © 2003 John Wiley & Sons, Ltd.
Advanced FinFET process technology for 20 nm node and beyond (2011)

One of the biggest challenges for the VLSI circuits with 20-nm-technology nodes and beyond is to overcome the issue of a catastrophic increase in power dissipation of the circuit due to short channel effects (SCEs). Fortunately, double-gate FinFETs have a promising potential to overcome this issue due to their superior SCE immunity even with an undoped channel thanks to the 3D structure. This paper presents novel FinFET process technologies for 20 nm node and beyond.
Antiemetic Effects of YM060, a Potent and Selective Serotonin (5HT)3-Receptor Antagonist, in Ferrets and Dogs (1991)

YM060, (R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-lH-benzimidazole hydrochloride, is a new serotonin (5HT)3-receptor antagonist. We examined the effects of YM060 on chemotherapeutic agent-, apomorphine- and copper sulfate-induced emesis. Intravenous YM060 potently prevented cisplatin (10mg/kg, i.v.)-induced emesis with ED50 values of 0.06 (0.05-0.07) μg/kg. i.v. in ferrets. Based on the ED50 values. YM060 was 300, 20 and 100 times more potent than ondansetron, granisetron and the S-isomer of YM060, respectively. The relative potencies of these drugs described above were similar to those in the previously reported 5HT3-receptor antagonism. YM060 given orally also potently inhibited cisplatin (10 mg/kg, i.p.)- and cyclophosphamide (200 mg/kg. i.p.(-induced emesis in ferrets with ED50 values of 0.1 (0.09-0.11) and 0.02 (0.16-0.27)μg/kg. p.o., respectively. All tested 5HT3-receptor antagonists including YM060 failed to prevent apomorphine (0.1 mg/kg, s.c.(-induced emesis in dogs and copper sulfate (1%. 10 ml, p.o.(-induced emesis in ferrets. Our data indicate that YM060 is a highly potent inhibitor of chemotherapeutic agent-induced emesis and that the antiemetic effect of YM060 may be depend on 5HT3-receptor antagonism.
A syllabic companding translinear filter (2002)

A distortionless syllabic companding filter can be obtained theoretically by updating the state variables of the filter as a function of the compression signal. In translinear filters, this is accomplished by adding a compensation current to all the capacitors in the filter. This current can be generated using only one capacitor and one transistor. Simulation results of a translinear syllabic companding differential filter are presented.
Chirped-pulse programming of optical coherent transient true-time delays (1998)

Programming an optical coherent transient true-time delay device with two frequency-chirped pulses provides a novel means of performing broadband (> >GHz) true-time delay with a wide dynamic range of delays with fine temporal resolution. We have demonstrated true-time delays exceeding 2micros with sub-100-ps resolution. Chirped-pulse programming has the advantages over the previously proposed brief pulse programming [Opt. Lett. 21 1102 (1996)] of reduced instantaneous power requirements and the ability to control the true-time delay by frequency shifting the programming pulses.
New Amebacides. IV.<sup>1</sup> The Preparation of Some N-Benzyl-N-(2-carbamylethyl)- and N-Benzyl-N-(2-cyanoethyl)-haloacetamides (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Amebacides. IV.1 The Preparation of Some N-Benzyl-N-(2-carbamylethyl)- and N-Benzyl-N-(2-cyanoethyl)-haloacetamidesAlexander R. Surrey and George Y. LesherCite this: J. Am. Chem. Soc. 1956, 78, 11, 2573–2576Publication Date (Print):June 1, 1956Publication History Published online1 May 2002Published inissue 1 June 1956https://pubs.acs.org/doi/10.1021/ja01592a067https://doi.org/10.1021/ja01592a067research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dependent Source and Channel Rate Allocation for Video Transmission (2004)

A general joint source-channel rate allocation scheme for a dependent video coding environment is presented. It is assumed that the source coders rely on motion-compensated prediction, and thus error propagation will contribute significantly to the degradation of the reconstructed video. The rate allocation methodology is based upon generation of operational distortion-rate characteristics. In order to reduce computational complexity, these surfaces and the channel code performance are modeled. An analytic method for computing optimal rate allocation across frames in a video sequence is then introduced. Comparisons are made between equal error protection and unequal error protection over video frames. Results are shown for H.263 compressed video used in conjunction with rate-compatible punctured convolutional codes.
Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer (2014)

Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD(+) AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy. Our results suggest that BPR1J-340 may be further developed in the preclinical and clinical studies as therapeutics in AML treatments.
Vascular injury and time course of smooth muscle cell proliferation after experimental holmium laser angioplasty. (1992)

Holmium laser treatment leads to considerable vessel wall injury and results in SMC proliferation in the intimal and medial layer with a maximum of proliferative activity within the first 2 weeks. Subsequently, this results in considerable intimal and medial hyperplasia within 6 weeks after treatment.
Endothelial Progenitor Cells for Vascular Medicine (2007)

The regenerative potential of stem cells has recently been under intense investigation. In vitro, stem and progenitor cells have the ability for self-renewal and differentiation into organ-specific cell types. In vivo, transplantation of these cells may reconstitute organ systems, as shown in animal models of disease. In contrast, differentiated cells do not exhibit such characteristics. Human endothelial progenitor cells (EPCs) have been isolated from the peripheral blood of adult individuals, expanded in vitro and committed to an endothelial lineage in culture. The transplantation of these human EPCs has been shown to facilitate successful salvage of limb vasculature and perfusion in athymic nude mice with severe hindlimb ischemia, while differentiated endothelial cells (human microvascular endothelial cells) failed to accomplish limb-saving neovascularization. Future studies will clarify the mechanisms and circumstances that may be responsible for modulating the contribution of vasculogenesis to postnatal neovascularization. Specifically in this regard, it is intriguing to consider the possibility that certain angiogenic growth factors acknowledged to promote both angiogenesis and vasculogenesis in the embryo, but have been assumed to promote neovascularization exclusively by angiogenesis in the adult, may in fact promote migration, proliferation, and mobilization of EPCs from bone marrow. The possibility that modulation of vasculogenesis can be used therapeutically to augment as well as inhibit neovascularization deserves further investigation.
Simultaneous Detection and Genotyping of “Norwalk-Like Viruses” by Oligonucleotide Array in a Reverse Line Blot Hybridization Format (2000)

"Norwalk-like viruses" (NLVs) are the most common cause of outbreaks of nonbacterial gastroenteritis worldwide. To date, the method most widely used for typing of NLV strains is sequencing and subsequent phylogenetic analysis of reverse transcription (RT)-PCR products, which has revealed the existence of stable distinct lineages (genotypes). This typing method is rather costly, not routinely used in clinical laboratories, and not very suitable for the analysis of large numbers of samples. Therefore, we have developed a rapid and simple method for genotyping of NLVs. The method, designated reverse line blot hybridization, is based on the nucleotide divergence of a region of the gene for RNA polymerase which can be used to classify NLVs into genotypes. NLV RNA was amplified by RT-PCR and then hybridized to 18 different membrane-bound oligonucleotides that were able to discriminate among 13 NLV genotypes. Application of the method to a panel of 132 positive stool samples from 34 outbreaks and 20 sporadic cases of gastroenteritis collected in a 6-year period (1994 to 1999) resulted in successful genotyping of 124 samples (94%), as confirmed by phylogenetic analysis. The nucleotide sequences of the remaning eight strains (6%) from three outbreaks did not cluster with the known NLV genotypes. Phylogenetic analysis of the complete and partial open reading frame 2 (capsid gene) sequences of these strains revealed the existence of one novel genotype (Alphatron) and one potentially novel genotype (Amsterdam). This novel method, which allows simultaneous detection and genotyping of NLVs, is useful in the diagnosis and typing of NLVs obtained from outbreaks and in large-scale epidemiological studies.
The Role and Influence of the LDP in the Budgetary Processes (2002)

Abstract The management and manipulation of budget outputs in Japan helped the Liberal Democratic Party (LDP) to maintain itself in power for thirty-eight years until 1993 and, less certainly, after its return to the leadership and domination of the coalition governments from 1996. Through governmental and party organizations, the LDP had begun to play a more active and interventionist role in policy-making generally from the early 1970s. Opportunities for the LDP to influence those processes and their outputs occurred at four main stages: first, at the time of the formulation of the overall budget strategy, and the prescription of the ceilings for the General Account and Fiscal Investment Loan Programme Budgets; second, at the stage of compiling budget requests within each Spending Ministry and Agency; third, after the submission of formal budget requests, at the successive stages of hearing, examination, negotiation, and ‘revival’ conducted by the Ministry of Finance's Budget Bureau; and fourth, at the point of delivery of benefits, services, investments, grants, subsidies, and so on.
TOA estimation for IR-UWB systems with different transceiver types (2006)

In this paper, performances of stored-reference, transmitted-reference (TR), and energy-detection (ED)-based time-of-arrival estimation techniques are analyzed for impulse-radio ultra-wideband (IR-UWB) systems at sub-Nyquist sampling rates. First, an additive white Gaussian noise channel is considered to emphasize certain fundamental issues related to these different transceivers. In particular, energy collection characteristics and decision statistics are presented. Probability of accurate peak detection is analyzed for each transceiver, and receiver operating characteristics for the leading edge are derived. Effects of number of pulses per symbol and number of averaging symbols are investigated in detail. Then, realistic multipath channels are addressed, and various maximum-likelihood estimation approaches are investigated. A new estimator that jointly exploits the noise statistics and power delay profile of the channel is proposed, and a Bayesian estimator that (ideally) gives a lower bound is analyzed. Simulation results show that while ED and TR have better energy collection capabilities at low-rate sampling, they suffer from distributing the energy over time.
ChemInform Abstract: KETEN‐GENERATOREN UND KETEN‐REAKTIONSAPPARATUREN FUER DEN LABOR‐, TECHNIKUMS‐ UND PRODUKTIONSMASSSTAB (1973)

Abstract Es werden Ketengeneratoren für die Herstellung von Keten zu Labor‐, Technikums‐ und Produktionszwecken beschrieben.
Mid-infrared pulses generated from the mixing output of an amplified, dual-wavelength Ti:sapphire system (2002)

We demonstrate the generation of femtosecond mid-infrared pulses by direct difference-frequency mixing in a AgGaS(2) crystal of two intense pulses from a dual-wavelength oscillator that have been simultaneously amplified in a single regenerative amplifier. A pulse energy of as much as 1.6 muJ was achieved at wavelengths of 9-11 mum.