gebhart/patrepeval huggingface dataset:
Emerging calendaring and scheduling standards (1997)

Calendaring and scheduling products are well established, but they have one significant drawback: they are usually limited to exchanging information among users of the same system, usually within the boundaries of a single organization. Thus you cannot use them to schedule a meeting with some one who uses a different application. Currently proprietary standards exist to structure some types of calendaring and scheduling information, but no single, open specification comprehensively addresses the needs of collecting and communicating information across many channels, such as phones, e-mail, and face to face meetings. However, important progress has been and is being made in standardizing both the format and exchange of this inherently complex information. The group working on bringing standardization to calendaring and scheduling applications-a working group of the Internet Engineering Task Force (IETF)-is nearing the final stages in developing standards to enable different products to interoperate and to work across organizational boundaries. These standards-which include iCalendar, iTIP, IMIP, and iRIP-will be published by the end of the year (1997). The benefit of standardizing such interoperability is clear: users will be able to communicate calendaring and scheduling information among different applications by using a variety of communication protocols. The applications that will benefit from these new standards include familiar mainframe products, LAN based group scheduling products, and desktop and mobile personal information managers (PIMs).
Sensitivity limits of strain mapping procedures using high‐resolution electron microscopy (1998)

Strain detection limits achieved by several approaches of strain mapping differing in the procedure of determining positions of intensity maxima have been compared. Algorithms which simultaneously take into account the two‐dimensional intensity distribution around maximum positions yield similar detection limits and are superior to those performing successive one‐dimensional cuts. Investigations of the effect of image recording imply that the use of photographic plates is superior to direct image recording using a slow‐scan CCD camera because of larger sampling rates and a larger field of view. It is finally shown that the choice of specimen preparation technique substantially affects the strain detection limit with cleaved samples yielding results which are a factor of about three better than ion‐milled samples.
An integrated optic RE spectrum analyzer in a ZnO-GaAs-AlGaAs waveguides (1990)

A report is presented on the realization of an integrated optic RF spectrum analyzer (IOSA) that combines a wideband acoustooptic Bragg cell and a pair of waveguide lenses in ZnO/GaAs/Al/sub 0.15/Ga/sub 0.85/As composite waveguide 7*23 mm/sup 2/ in size. A total of 10 and 40 channels at the center frequencies of 167 MHz and 500 MHz, respectively, and a frequency resolution of 5.5 MHz were realized. The diffraction efficiencies of 11.5%/W and 4.0%/W of RF drive power at the center frequencies of 167 MHz and 500 MHz, respectively, and a dynamic range larger than 16 dB were measured. Further integration of this IOSA (integrated optic spectrum analyzer) with a laser source, a photodetector array, and electronic driving circuits could produce a monolithically integrated optic RF spectrum analyzer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new subtribal classification of the tribe Anthemideae (Compositae) (2007)

A new subtribal classification of the Compositae-Anthemideae is presented based on phylogenetic reconstructions for sequence information of the internal transcribed spacer (ITS) region of the nuclear ribosomal DNA (nrDNA) for 103 of the 111 accepted genera of the tribe. Results of the present analyses are compared with results from phylogenetic analyses based on cpDNA ndhF sequence variation and discussed in conjunction with morphological, anatomical, cytological, embryological and phytochemical evidence. As a result, 14 subtribes are circumscribed and described in detail, with information provided concerning the generic members and the geographical distribution of these entities. Four subtribes (i.e. Osmitopsidinae, Phymasperminae, Pentziinae and Leucanthemopsidinae) are described as new to science, for a further subtribe a new name (Glebionidinae, replacing the illegitimate Chrysantheminae) is validated.
A Case of an Eosinophilic Granuloma Mimicking a Submucosal Tumor in the Ascending Colon Probably Caused by Anisakis (2008)

Anisakiasis in the gastrointestinal tract is caused by the ingestion of raw marine fish that contain Anisakis lavae. In rare cases, Anisakiasis is found as an eosinophilic granuloma that mimics a submucosal tumor. The diagnosis is usually made after surgical resection. Several cases of gastric anisakiasis imitating a submucosal lesion have been reported. However, colonic anisakiasis forming a submucosal lesion is very rare and only a few cases have been reported. All of the cases were confirmed after surgery. Recently, we encountered a male patient with a submucosal lesion on the ascending colon during a health screening. Several biopsies were performed on the same site as the lesion. The pathological finding was eosinophilic granuloma. We tentatively diagnosed the patient with eosinophilic granuloma due to Anisakis as the patient consumed raw seafood and eosinophilia was detected on a laboratory test. We decided not to perform any procedure. One month later, the eosinophilic granuloma disappeared as seen on a follow-up colonoscopy. (Korean J Gastrointest Endosc 2008;37:127-131)
SoC energy savings = reduce+reuse+recycle: A case study using a 660MHz DC-DC converter with integrated output filter (2008)

This paper advocates dasiareduce, reuse, recyclepsila as a complete energy savings strategy. While reduction has been common to date, there is growing need to emphasize reuse and recycling as well. We design a DC-DC buck converter to demonstrate the 3 techniques: reduce with low-swing and zero voltage switching (ZVS), reuse with supply stacking, and recycle with regulated delivery of excess energy to the output load. The efficiency gained from these 3 techniques helps offset the loss of operating drivers at very high switching frequencies which are needed to move the output filter completely on-chip. A prototype was fabricated in 0.18 mum CMOS, operates at 660 MHz, and converts 2.2 V to 0.75-1.0 V at ~50 mA.
Infektion im Laboratorium - zugleich Stellungnahme zu der Arbeit von W. Wundt in dieser Wochenschrift 89 (1964), 1577 (1965)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Pharmacokinetics of aprepitant and dexamethasone after administration of chemotherapeutic agents and effects of plasma substance P concentration on chemotherapy-induced nausea and vomiting in Japanese cancer patients (2010)

This study demonstrated similar plasma pharmacokinetics of aprepitant in Japanese and non-Japanese, the validity of reducing dexamethasone dose, and the existence of increased plasma substance P concentration in patients receiving highly emetogenic cisplatin-based chemotherapy.
Vehicular opportunistic communication under the microscope (2007)

We consider the problem of providing vehicular Internet access using roadside 802.11 access points. We build on previous work in this area [18, 8, 5, 11] with an extensive experimental analysis of protocol operation at a level of detail not previously explored. We report on data gathered with four capture devices from nearly 50 experimental runs conducted with vehicles on a rural highway. Our three primary contributions are: (1) We experimentally demonstrate that, on average, current protocols only achieve 50% of the overall throughput possible in this scenario. In particular, even with a streamlined connection setup procedure that does not use DHCP, high losses early in a vehicular connection are responsible for the loss of nearly 25% of overall throughput, 15% of the time. (2) We quantify the effects of ten problems caused by the mechanics of existing protocols that are responsible for this throughput loss; and (3) We recommend best practices for using vehicular opportunistic connections. Moreover, we show that overall throughput could be significantly improved if environmental information was made available to the 802.11 MAC and to TCP. The central messagein this paper is that wireless conditions in the vicinity of a roadside access point are predictable, and by exploiting this information, vehicular opportunistic access can be greatly improved.
Sonic film memory (1966)

The sonic film memory represents a novel approach to the storage of digital information. Thin magnetic films and scanning strain waves are combined to realize a memory in which information is stored serially. The remanent property of magnetic films is used for nonvolatile storage. The effect of strain waves on magnetic films is used to obtain serial accessing. This effect is also used to derive a nondestructive read signal for interrogation.
Asymmetric Synthesis of α‐Substituted N‐Methylsulfonamides. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Technology for the more and all electric aircraft of the future (2016)

There has recently been a major change in the design of aircraft. Electrical systems are being used in applications, which have traditionally been powered by hydraulic or pneumatic sources. The Boeing 787 and the Airbus A380 both have significantly larger electrical systems than any previous aircraft and this has led to a wealth of technology developments. Electrical systems are now being use for aircraft actuation systems, wing ice protection, environmental control systems and fuel pumping. These new systems are helping to make future aircraft more fuel efficient and quieter, improving the environment for everyone. However, this is just the start of the changes to aircraft design. A roadmap leading to a fully electric aircraft for civil applications is now emerging. The technology challenges involved for power electronics, electrical systems, control and electrical machines are being defined and these requirements give a view of the fantastic opportunities for research teams to make a real impact. The issues to be resolved include equipment weight, volume, cost and reliability. The More Electric Aircraft concept offers many potential benefits in the design and efficiency of future large, manned aircraft. In the future it is predicted that the trend in transportation electrification will lead to the development of all electric civilian aircraft concepts. In this paper typical aircraft electrical power systems and the loads associated with these requirements are described as well as the challenges for the aerospace industry in this implementation. The importance of Power Electronics as an enabling technology for this step change in aircraft design is considered and examples of typical system designs are discussed.
Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells. (1985)

Histidinol-resistant (HisOHR) mutants with up to a 30-fold increase in histidyl-tRNA synthetase activity have been isolated by stepwise adaptation of wild-type Chinese hamster ovary (CHO) cells to increasing amounts of histidinol in the medium. Immunoprecipitation of [35S]methionine-labeled cell lysates with antibodies to histidyl-tRNA synthetase showed increased synthesis of the enzyme in histidinol-resistant cells. The histidinol-resistant cell lines had an increase in translatable polyadenylated mRNA for histidyl-tRNA synthetase. A cDNA for CHO histidyl-tRNA synthetase has been cloned, using these histidyl-tRNA synthetase-overproducing mutants as the source of mRNA. Southern blot analysis of wild-type and histidinol-resistant cells with this cDNA showed that the histidyl-tRNA synthetase DNA bands were amplified in the resistant cells. These HisOHR cells owed their resistance to histidinol to amplification of the gene for histidyl-tRNA synthetase.
Quantum noise analysis of frequency-doubling ring lasers: nonlinearity-induced noise enhancement and its dependence on gain profile (1998)

Using a traveling-wave model that can treat the spatial evolution of light fields, quantum noise characteristics of frequency-doubling ring lasers are analyzed under single-frequency operation. Systems under consideration are the discrete system, in which a laser crystal and a nonlinear crystal are separately installed, and the self-doubling system, which is equipped with a nonlinear crystal with laser gain. It is predicted that the unsaturated gain profile does not affect noise characteristics of the discrete system: nonlinear loss-induced noise enhancement (NINE), i.e., an increase of the spontaneous emission noise associated with enlarged gain that compensates the nonlinear loss, manifests itself at a specific operating point regardless of the gain profile. In the self-doubling system, on the other hand, the manifestation of NINE will arise for higher harmonic output compared with that in the discrete system. For the self-doubling system, moreover, the profile of the unsaturated gain causes a significant difference in NINE; because NINE is associated with a large field variation, it is effectively suppressed by configuring the gain profile to be flat or increasing along the direction of laser field propagation.
Chemically Defined Media for Growth of <i>Haemophilus influenzae</i> Strains (2003)

A chemically defined medium that supports the growth of both encapsulated and nontypeable Haemophilus influenzae strains in broth to densities that are >/= 10(9) CFU/ml or on agar plates is described. The mean generation time of a panel of clinical isolates was comparable to that in rich, chemically undefined media (brain-heart infusion broth supplemented with heme and beta-NAD).
The Cation−π Interaction at Protein–Protein Interaction Interfaces: Developing and Learning from Synthetic Mimics of Proteins That Bind Methylated Lysines (2012)

First discovered over 60 years ago, post-translational methylation was considered an irreversible modification until the initial discoveries of demethylase enzymes in 2004. Now researchers understand that this process serves as a dynamic and complex control mechanism that is misregulated in numerous diseases. Lysine methylation is most often found on histone proteins and can effect gene regulation, epigenetic inheritance, and cancer. Because of this connection to disease, many enzymes responsible for methylation are considered targets for new cancer therapies. Although our understanding of the biology of post-translational methylation has advanced at an astonishing rate within the last 5 years, chemical approaches for studying and disrupting these pathways are only now gaining momentum. In general, enzymes methylate lysine and arginine residues with very high specificity for both the location and methylation state. Each methylated target serves as the focused hot spot for an inducible protein-protein interaction (PPI). Conceptually, lysine or arginine methylation is a subtle modification that leads to no change in charge and small changes in size, but it significantly alters the hydration energies and hydrogen bonding potential of these side chains. Nature has evolved a special motif for recognizing the methylation states of lysine, called the "aromatic cage", a collection of aromatic protein residues, often accompanied by one or more neighboring anionic residues. The combination of favorable cation-π, electrostatic, and van der Waals interactions, as well as size matching, gives these proteins a high degree of specificity for the methylation state. This Account summarizes the development of various supramolecular host system scaffolds developed to recognize and bind to ammonium cations, such as trimethyllysine, on the basis of their methylation state. Early systems bound to their targets in pure, buffered water but failed to achieve biochemically relevant affinities and selectivities. Surprisingly, the use of the simple and very well-known p-sulfonatocalix[4]arene provides protein-like affinities and selectivities for trimethyllysine in water. New analogs, created by synthetic modification of the same scaffold, allow for further tuning of affinities and selectivities for trimethyllysine. Our studies of each family of hosts paint a consistent picture: cation-π interactions and electrostatics are important, and solvation effects are complex. Rigidity is especially important for host-guest systems that function in pure water. Despite their simplicity, synthetic systems that take these lessons into account can achieve affinities that rival or surpass those of their naturally evolved counterparts. The stage is now set for the next act: the use of such compounds as tunable and adaptable tools for modern chemical biology.
Learning Mixed Membership Mallows Models from Pairwise Comparisons (2015)

We propose a novel parameterized family of Mixed Membership Mallows Models (M4) to account for variability in pairwise comparisons generated by a heterogeneous population of noisy and inconsistent users. M4 models individual preferences as a user-specific probabilistic mixture of shared latent Mallows components. Our key algorithmic insight for estimation is to establish a statistical connection between M4 and topic models by viewing pairwise comparisons as words, and users as documents. This key insight leads us to explore Mallows components with a separable structure and leverage recent advances in separable topic discovery. While separability appears to be overly restrictive, we nevertheless show that it is an inevitable outcome of a relatively small number of latent Mallows components in a world of large number of items. We then develop an algorithm based on robust extreme-point identification of convex polygons to learn the reference rankings, and is provably consistent with polynomial sample complexity guarantees. We demonstrate that our new model is empirically competitive with the current state-of-the-art approaches in predicting real-world preferences.
Rate-Dependent Effects of Detajmium and Propafenone on Ventricular Conduction and Refractoriness in Isolated Guinea Pig Hearts (1996)

Detajmium (4--3'-diethylamino-2'-hydroxypropyl--ajmalin) is an Na(+)-channel-blocking drug with an extremely long recovery from use-dependent sodium channel block. The aim of the present study was to investigate the rate-dependent effects of detajmium on the intraventricular conduction of isolated, spontaneously beating, guinea pig hearts in comparison with the effects of propafenone. Detajmium (0.3 microM) and propafenone (0.3 microM) caused comparable prolongations of the intraventricular conduction time during sinus rhythm. The time to steady state of the rate-dependent QRS prolongation during rapid ventricular pacing follows an exponential function of the beat number after an abrupt change of frequency and is characterized by a drug-specific time constant. This time constant was significantly longer for detajmium (tau = 265 +/- 165 beats; mean +/- SEM; n = 6) than for propafenone (tau = 31 +/- 4 beats; n = 11; p < 0.01). In the presence of propafenone, QRS duration peaked initially before decreasing to a steady state. Detajmium, in contrast, progressively broadened the QRS complex. Both substances caused the greatest increase in the ventricular effective refractory period (V-ERP) when the number of conditioning stimuli (interstimulus interval, 120 ms) was in the range of the time constant. However, when the number of conditioning stimuli was further increased, the V-ERP for propafenone diminished progressively. In conclusion, propafenone displayed, in comparison with detajmium, only a transient rate-dependent effect on intraventricular conduction and V-ERP.
Secondary deuterium isotope effects for acid-catalyzed hydrolysis of inosine adenosine (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary deuterium isotope effects for acid-catalyzed hydrolysis of inosine adenosineR. Romero, R. Stein, H. G. Bull, and E. H. CordesCite this: J. Am. Chem. Soc. 1978, 100, 24, 7620–7624Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/ja00492a030https://doi.org/10.1021/ja00492a030research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Research on Customer Relation Management in e-Commerce Environment (2011)

Customer relation management(CRM) is an important management concept and technique, this paper introduces the reasons for the rise of CRM and analyzes its role on enterprise management. Through implementing database marketing and data mining strategies, based on information technology, customer relationship management may facilitate companies build long-term customer relationship, maintain customer loyalty, achieve competitive advantage and sustainable development.
Genetic Deficiency of Chemokine Receptor CCR5 Is a Strong Risk Factor for Symptomatic West Nile Virus Infection: A Meta‐Analysis of 4 Cohorts in the US Epidemic (2008)

West Nile virus (WNV) causes disease in approximately 20% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.