gebhart/patrepeval huggingface dataset:
Thiazide diuretics and male sexual dysfunction (1992)

Abstract The associations that have been noted between the clinical use of the thiazide diuretics and impairment of male sexual performance remain enigmatic. Recent studies are reviewed, in which aspects of the male sexual dysfunction in hypertensive men following treatment with thiazide diuretics were examined. The data are interpreted in light of previously published studies on the subject to suggest that penile erectile defects and decrements in sexual activities are specifically related to thiazide administration. A rodent model of thiazideinduced male sexual dysfunction is introduced that documents dose‐related impairment, by hydrochlorothiazide, of penile erectile reflexes and male copulatory performance. The etiology of thiazide‐induced male sexual dysfunction is hypothesized to result from alterations in sodium excretion that alter afferent renal nerve input to hypothalamic areas regulating male sexual responses.
Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet (2002)

The ciliary rootlet, first recognized over a century ago, is a prominent structure originating from the basal body at the proximal end of a cilium. Despite being the largest cytoskeleton, its structural composition has remained unknown. Here, we report a novel 220-kD protein, designated rootletin, found in the rootlets of ciliated cells. Recombinant rootletin forms detergent-insoluble filaments radiating from the centrioles and resembling rootlets found in vivo. An mAb widely used as a marker for vertebrate rootlets recognizes an epitope in rootletin. Rootletin has a globular head domain and a tail domain consisting of extended coiled-coil structures. Rootletin forms parallel in register homodimers and elongated higher order polymers mediated by the tail domain alone. The head domain may be required for targeting to the basal body and binding to a kinesin light chain. In retinal photoreceptors where rootlets appear particularly robust, rootlets extend from the basal bodies to the synaptic terminals and anchor ER membranes along their length. Our data indicate that rootlets are composed of homopolymeric rootletin protofilaments bundled into variably shaped thick filaments. Thus, rootletin is the long-sought structural component of the ciliary rootlet.
The American introduction of “maternalism” as a historical concept (1997)

Abstract The concept of maternalism has, in recent years, gained currency among both American and European feminist scholars. Since its introduction in the United States in the early 1990s, maternalism has become a key concept in many feminist writings about gender and the welfare state. But, even though maternalism is both well known and well used, it is hard to find any unambiguous definition of this concept. In other words, maternalism is a rather slippery concept, because of its multiple definitions and applications. Hence to continue using this concept, we need to clarify its meaning more closely.
NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts (2010)

Previous studies have reported the anti-inflammatory properties of pomegranate extracts, suggesting that ellagitannins (ET) and ellagic acid (EA) are the main anti-inflammatory compounds. However, both ET and EA are metabolised in vivo by the gut microbiota to yield urolithins (Uro) which can be found in the gut and in systemic bloodstream. The present study was carried out to evaluate the individual effect of EA and their microbiota-derived metabolites Uro on colon fibroblasts upon IL-1β treatment as an in vitro inflammation model. Uro-A and Uro-B (10 μ m ) inhibited PGE 2 production (85 and 40 %, respectively) after IL-1β stimulation, whereas EA did not show any effect. Uro-A, but not Uro-B, down-regulated cyclo-oxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1) mRNA expression and protein levels. Both Uro inhibited NF-κB translocation to nucleus. Slight but significant effects were found in the activation of mitogen-activated protein kinase (MAPK) pathways. Uro-A lowered c-Jun N-terminal kinase phosphorylation state, and both Uro inhibited p38 activation. No metabolites derived from Uro or EA were found in the cell media upon incubation of EA or Uro with the cells, and only traces of the compounds were found inside the cells. The present results suggest that Uro, mainly Uro-A, are the main compounds that are responsible for the pomegranate anti-inflammatory properties. The mechanism of action implicated seems to be via the inhibition of activation of NF-κB and MAPK, down-regulation of COX-2 and mPGES-1 expressions, and consequently,via the reduction of PGE 2 production. Taking into account that Uro did not enter the cells, a competitive binding for IL-1β membrane receptor cannot be discarded.
Clinical implications of hepatitis B virus mutations: Recent advances (2014)

Hepatitis B virus (HBV) infection is a major cause of acute and chronic hepatitis, and of its long-term complications. It is the most variable among DNA viruses, mostly because of its unique life cycle which includes the activity of error-prone enzyme, reverse transcriptase, and the very high virion production per day. In last two decades, numerous research studies have shown that the speed of disease progression, reliability of diagnostic methods and the success of antiviral therapy and immunization are all influenced by genetic variability of this virus. It was shown that mutations in specific regions of HBV genome could be responsible for unwanted clinical outcomes or evasion of detection by diagnostic tools, thus making the monitoring for these mutations a necessity in proper evaluation of patients. The success of the vaccination programs has now been challenged by the discovery of mutant viruses showing amino acid substitutions in hepatitis B surface antigen (HBsAg), which may lead to evasion of vaccine-induced immunity. However, the emergence of these mutations has not yet raised concern since it was shown that they develop slowly. Investigations of HBV genetic variability and clinical implications of specific mutations have resulted in significant advances over the past decade, particularly in regard to management of resistance to antiviral drugs. In the era of drugs with high genetic barrier for resistance, on-going monitoring for possible resistance is still essential since prolonged therapy is often necessary. Understanding the frequencies and clinical implications of viral mutations may contribute to improvement of diagnostic procedures, more proper planning of immunization programs and creating the most efficient therapeutic protocols.
Power Consumption Analysis of a Bluetooth over Ultra Wide Band System (2007)

Bluetooth (BT) is a Wireless Personal Area Networks (WPAN) technology that is becoming increasingly popular for low power, low data rate and short distance applications. The WiMedia Alliance specifies an Ultra Wide Band (UWB) standard that defines high data rate communications of up to 480 Mbps, within a range up to 10 meters. The industry is now merging these two technologies into one single specification in order to get the best out of them. On one side the low power consumption and usability of the BT solutions, on the other side the high data rate provided by UWB. The aim of this paper is to provide a power consumption analysis of the low power modes of both standards and an energy efficiency comparison for the different modes of operation.
Euler buckling and nonlinear kinking of double-stranded DNA (2013)

The bending stiffness of double-stranded DNA (dsDNA) at high curvatures is fundamental to its biological activity, yet this regime has been difficult to probe experimentally, and literature results have not been consistent. We created a 'molecular vise' in which base-pairing interactions generated a compressive force on sub-persistence length segments of dsDNA. Short dsDNA strands (<41 base pairs) resisted this force and remained straight; longer strands became bent, a phenomenon called 'Euler buckling'. We monitored the buckling transition via Förster Resonance Energy Transfer (FRET) between appended fluorophores. For low-to-moderate concentrations of monovalent salt (up to ∼150 mM), our results are in quantitative agreement with the worm-like chain (WLC) model of DNA elasticity, without the need to invoke any 'kinked' states. Greater concentrations of monovalent salts or 1 mM Mg(2+) induced an apparent softening of the dsDNA, which was best accounted for by a kink in the region of highest curvature. We tested the effects of all single-nucleotide mismatches on the DNA bending. Remarkably, the propensity to kink correlated with the thermodynamic destabilization of the mismatched DNA relative the perfectly complementary strand, suggesting that the kinked state is locally melted. The molecular vise is exquisitely sensitive to the sequence-dependent linear and nonlinear elastic properties of dsDNA.
Real-time roadway emissions estimation using visual traffic measurements (2011)

Monitoring the state of our roadways has become increasingly important in order to better manage traffic congestion. Sophisticated traffic management systems are being developed that are able to process both static and mobile sensor data that provide traffic information for the roadway network. In addition to typical traffic data such as flow, density, and average traffic speed, there is now strong interest in environmental factors such as greenhouse gas and pollutant emissions from traffic. It is now possible to combine real-time traffic data along with instantaneous emission models to estimate these environmental measures in real-time. In this paper, we describe a system that can more accurately determine average traffic fuel economy, CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , CO, HC, and NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> emissions using a computer vision-based methodology that also incorporates energy/emission profiles from the comprehensive modal emissions model CMEM and EPA's MOVES emission factor database. The vision system provides information not only on average traffic speed, density, and flow, but also on individual vehicle trajectories and recognized vehicle categories. The vehicle trajectories for the specific identified categories are used by the emissions model to predict environmental parameters. This estimation process provides far more dynamic and accurate environmental information compared to static emission inventory estimation models.
Using machine learning for concept extraction on clinical documents from multiple data sources (2011)

Our study shows how the performance of machine learning taggers is degraded when they are ported across clinical documents from different sources. The portability of taggers can be enhanced by training on datasets from multiple sources. The study also shows that BioTagger-GM can be easily extended to detect clinical concept mentions with good performance.
Maxillary Advancement With Internal Distraction Device in Cleft Palate Patients (2007)

This study aimed to evaluate the results of maxillary advancement by using internal Le Fort 1 distractors on six patients with unilateral cleft lip and palate who had maxillary hypoplasia. The retrognathic maxilla of five patients were protracted with distractor bilaterally, and asymmetric advancement was performed in one patients. A removable intraoral acrylic appliance was used as an anchorage appliance in two patients, and Ragno fan-type expander appliance was used in the others to prevent maxillary collapse during the distraction period. The maxilla of one patient was not distracted successfully due to the maxillary collapse in result of breaking the removable anchorage appliance away. Lateral cephalograms were evaluated before 3 and 12 months after distraction.A desired level of advancement was attained in five patients. In one patient distraction was not performed due to the maxillary collapse. In one of the five patients with a wide oronasal fistula, the size of the fistula was decreased with asymmetric advancement of right and left maxillary segments. Following the retention period of 12 months, the results were stable. It was concluded that effective and easy distraction is possible with internal Le Fort 1 distractors in cleft lip and palate patients who requires maxillary advancement.
Interactions among Membrane and Soluble Components of the Flagellar Export Apparatus of <i>Salmonella</i> (2002)

Interactions among several components of the flagellar export apparatus of Salmonella were studied using affinity chromatography, affinity blotting, and fluorescence resonance energy transfer (FRET). The components examined were two integral membrane proteins, FlhA and FlhB, and two soluble components, FliH and the ATPase FliI. Affinity chromatography and affinity blotting demonstrated a heterologous interaction between FlhA and FlhB but not homologous FlhA-FlhA or FlhB-FlhB interactions. Both FlhA and FlhB consist of N-terminal transmembrane domains and C-terminal cytoplasmic domains (FlhA(C) and FlhB(C)). To study the interactions among the cytoplasmic components (FlhA(C), FlhB(C), FliH, and FliI), FRET measurements were carried out using fluorescein-5-isothiocyanate (FITC) as donor and tetramethylrhodamine-5- (and 6-) isothiocyanate (TRITC) as acceptor. To reveal the nature of the binding interactions, measurements were carried out in physiological buffer, at high salt (0.5 M NaCl) and in 30% 2-propanol. The results indicated that FlhA(C) could bind to FlhB(C) and both FlhA(C) and FlhB(C) could bind to themselves. Both FlhA(C) and FlhB(C) bound to FliH and FliI. Several in-frame deletion mutants of FliH were examined and found to have only minor effects of decreased binding to FlhA(C) and FlhB(C); deletions in the interior of the FliH sequence had a greater effect than those at the N terminus. The FliI mutants examined bound FlhA(C) and FlhB(C) about the same as or slightly more weakly than wild-type FliI. FliH bound more weakly to FliI carrying the N-terminal double mutation R7C/L12P than it did to wild-type FliI, confirming the importance of the N terminus of FliI for its interaction with FliH.
Collaborative web accessibility improvement (2009)

Collaborative accessibility improvement has great potential to make the Web more adaptive in a timely manner by inviting users into the improvement process. The Social Accessibility Project is an experimental service for a new needs-driven improvement model based on collaborative metadata authoring technologies. In 10 months, about 18,000 pieces of metadata were created for 2,930 webpages through collaboration. We encountered many challenges as we sought to create a new mainstream approach. The productivity of the volunteer activities exceeded our expectation, but we found large and important problems in the screen reader users' lack of awareness of their own accessibility problems. In this paper, we first introduce examples, analyze some statistics from the pilot service and then discuss our findings and challenges. Three future directions including site-wide authoring are considered.
Decision-directed coherent delay-lock tracking loop for DS-spread-spectrum signals (1991)

The authors present a nonconventional joint data demodulation-pseudo-noise (PN) code tracking scheme for direct sequence (DS) spread-spectrum (SS) signals which solves problems of component imbalance and sensitivity with hardware simplicity and no performance degradation. An integrate-and-dump Costas loop is used for carrier recovery and data demodulation of the SS signal. Both data and carrier are then used to derive the baseband error signal of the code tracking loop. Moreover, a single passband correlator is used to perform the early-late correlation, leading to a hardware complexity equivalent to that of the tau-dither scheme, but without its loss in performance. Results of a thorough theoretical analysis of the system in an additive Gaussian noise (AWGN) environment are reported. They provide performance curves in terms of steady-state jitter and mean time to first lock loss. A superior jitter performance for low values of E/sub b//N/sub 0/ with respect to a traditional noncoherent delay lock loop (DLL) is shown, along with the potential gain of Manchester coding upon the more usual NRZ format.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Discovery of <i>N</i>-((4-([1,2,4]Triazolo[1,5-<i>a</i>]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1<i>H</i>-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-β Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent (2014)

A series of 2-substituted-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)imidazoles was synthesized and evaluated to optimize a prototype inhibitor of TGF-β type I receptor kinase (ALK5), 6. Combination of replacement of a quinoxalin-6-yl moiety of 6 with a [1,2,4]triazolo[1,5-a]pyridin-6-yl moiety, insertion of a methyleneamino linker, and a o-F substituent in the phenyl ring markedly increased ALK5 inhibitory activity, kinase selectivity, and oral bioavailability. The 12b (EW-7197) inhibited ALK5 with IC50 value of 0.013 μM in a kinase assay and with IC50 values of 0.0165 and 0.0121 μM in HaCaT (3TP-luc) stable cells and 4T1 (3TP-luc) stable cells, respectively, in a luciferase assay. Selectivity profiling of 12b using a panel of 320 protein kinases revealed that it is a highly selective ALK5/ALK4 inhibitor. Pharmacokinetic study with 12b·HCl in rats showed an oral bioavailability of 51% with high systemic exposure (AUC) of 1426 ng × h/mL and maximum plasma concentration (Cmax) of 1620 ng/mL. Rational optimization of 6 has led to the identification of a highly potent, selective, and orally bioavailable ALK5 inhibitor 12b.
Quantum mechanics as a statistical theory (1949)

An attempt is made to interpret quantum mechanics as a statistical theory, or more exactly as a form of non-deterministic statistical dynamics. The paper falls into three parts. In the first, the distribution functions of the complete set of dynamical variables specifying a mechanical system (phase-space distributions), which are fundamental in any form of statistical dynamics, are expressed in terms of the wave vectors of quantum theory. This is shown to be equivalent to specifying a theory of functions of non-commuting operators, and may hence be considered as an interpretation of quantum kinematics . In the second part, the laws governing the transformation with time of these phase-space distributions are derived from the equations of motion of quantum dynamics and found to be of the required form for a dynamical stochastic process. It is shown that these phase-space transformation equations can be used as an alternative to the Schrödinger equation in the solution of quantum mechanical problems, such as the evolution with time of wave packets, collision problems and the calculation of transition probabilities in perturbed systems; an approximation method is derived for this purpose. The third part, quantum statistics , deals with the phase-space distribution of members of large assemblies, with a view to applications of quantum mechanics to kinetic theories of matter. Finally, the limitations of the theory, its uniqueness and the possibilities of experimental verification are discussed.
Histamine and Antihistamines in Anaphylaxis (2002)

Anaphylaxis and anaphylactoid reactions are potentially fatal. These disorders are sometimes iatrogenic, and increase with increased exposure to drugs, synthetic substances, and medical procedures. Non-IgE-mediated anaphylactoid reactions are common in medical settings and are clinically indistinguishable from anaphylaxis. These reactions may be unrecognized if a rigid classic definition of anaphylaxis is used. Histamine is a primary mediator of anaphylaxis and signs and symptoms of anaphylaxis can be reproduced by histamine infusion. Histamine triggers a cascade of inflammatory mediators and modulates its own release. H1-antihistamines are adjunctive treatment therapy for acute anaphylaxis and anaphylactoid reactions, in which many mediators of inflammation are involved. Compared with epinephrine, the first-response medication of choice, antihistamines have a slow onset of action, and they cannot block events that occur subsequent to histamine binding to its receptors. Antihistamines are an important component of regimens for the prevention of anaphylaxis and anaphylactoid reactions in patients at risk, and may eventually have more widespread application in the perioperative setting. In some instances, such as with exercise-induced anaphylaxis and reactions to latex in sensitized individuals, prophylaxis regimens are not always effective. H2-antagonists are not detrimental in the therapy of anaphylaxis and many studies show a favorable outcome when combining H1- and H2-antagonist therapy for prophylaxis. They should be added to therapy at the discretion of the treating physician. Because of decreased antimuscarinic and central nervous system side effects, the newer antihistamines can be given in high doses, allowing more complete blockade of histamine receptors. These agents should lead to a reevaluation of the usefulness of antihistamines in both the treatment of acute anaphylaxis and in prophylactic regimens. The unavailability of parenterally administered second-generation H1-antagonists limits their usefulness in acute anaphylaxis and perioperative prophylaxis.
Ship Classification in SAR Images Improved by AIS Knowledge Transfer (2018)

A major bottleneck in limiting the application of the existing methods of ship classification in synthetic aperture radar (SAR) images is the inadequate amount of labeled data available for training a classifier. However, generating ground truth involves expensive and time-consuming ground campaigns or is costly, since a high number of SAR image acquisition will be necessary. In contrast, an automatic identification system (AIS), which is an automatic tracking system used for monitoring maritime ships, can provide plenty of labeled ship samples that is relatively easier to be obtained. Inspired by these facts, this letter proposes to improve ship classification in SAR images by transferring AIS knowledge. We propose an improved multiclass adaptive support vector machine, combined with the naive geometric features (NGFs), to achieve transfer learning between the AIS domain and the SAR image domain. The experiments prove that the traditional method can be significantly improved by AIS information transfer, especially when only a few training samples in the SAR domain are available. In addition, it also shows that after feature selection, the performance of the proposed method can be close to that of the state of the art, even if by only using simpler NGFs and few training samples.