gebhart/patrepeval huggingface dataset:
Safety of synthetic trans‐resveratrol as a novel food pursuant to Regulation (EC) No 258/97 (2016)

Abstract Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked for an opinion on the safety of synthetic trans‐resveratrol as a novel food with a purity of ≥99% (w/w). The Panel considers that the information provided on the composition and specifications of the novel food is sufficient. The applicant intends to market the novel food as a food supplement in capsule or tablet form at daily doses up to 150 mg/day. The Panel considers that resveratrol does not have a nutritionally relevant role in the human diet and that the consumption of the novel food is not nutritionally disadvantageous. In accordance with the EFSA Scientific opinion on genotoxicity testing strategies, the Panel considers that the negative in vivo genotoxicity assay is sufficient to rule out the concern based on the positive in vitro chromosomal aberration tests. Reduced body weight gain is seen consistently in animal studies. On the basis of the BMDL05 of 344 mg/kg body weight (bw) per day derived from body weight data of female rats in a subchronic toxicity study and the intended intake of 150 mg/day, the margin of exposure is 172. For pregnant rats, it is below 62. Considering the weight of evidence, the Panel concludes that the intended intake level of 150 mg/day for adults does not raise safety concerns. The Panel notes that diarrhoea or other gastrointestinal symptoms were reported in four uncontrolled intervention studies at doses of 1 g resveratrol/day or higher. The Panel considers that the metabolite trans‐resveratrol sulfate could inhibit CYP enzymes in humans and may interact with medicines which are mainly metabolised by CYP2C9. The Panel concludes that the novel food, synthetic trans‐resveratrol, is safe under the proposed conditions of use.
Casting metal microstructures from a flexible and reusable mold (2009)

This paper describes casting-based microfabrication of metal microstructures and nanostructures. The metal was cast into flexible silicone molds which were themselves cast from microfabricated silicon templates. Microcasting is demonstrated in two metal alloys of melting temperature 70 °C or 138 °C. Many structures were successfully cast into the metal with excellent replication fidelity, including ridges with periodicity 400 nm and holes or pillars with diameter in the range 10–100 µm and aspect ratio up to 2:1. The flexibility of the silicone mold permits casting of curved surfaces, which we demonstrate by fabricating a cylindrical metal roller of diameter 8 mm covered with microstructures. The metal microstructures can be in turn used as a reusable molding tool.
Acellular Pertussis Trial (1996)

In the supplement to Pediatrics entitled Report of the Nationwide Multicenter Acellular Pertussis Trial, Edwards et al1 describe the serologic responses to individual antigens in thirteen acellular pertussis vaccines which were evaluated in the phase I/II trials performed by National Institute of Allergy and Infectious Diseases-supported Vaccine Treatment and Evaluation Units. In that article, the authors comment that "postimmunization geometric mean (antibody) titers [against pertussis toxin] differed significantly among the acellular vaccine groups and did not seem to correlate with the pertussis toxin (PT) antigen content of the vaccines."
CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4 <sup>+</sup> T-Cell Depletion in Human Lymphoid Tissue Ex Vivo (2001)

The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important virulence factor. Nef has several functions, including down-modulation of CD4 and class I major histocompatibility complex cell surface expression, enhancement of virion infectivity, and stimulation of viral replication in peripheral blood mononuclear cells. Nef also increases HIV-1 replication in human lymphoid tissue (HLT) ex vivo. We analyzed recombinant and primary nef alleles with highly divergent activity in different in vitro assays to clarify which of these Nef activities are functionally linked. Our results demonstrate that Nef activity in CD4 down-regulation correlates significantly with the efficiency of HIV-1 replication and with the severity of CD4(+) T-cell depletion in HLT. In conclusion, HIV-1 Nef variants with increased activity in CD4 down-modulation would cause severe depletion of CD4(+) T cells in lymphoid tissues and accelerate AIDS progression.
PARALLELIZATION OF MONTE CARLO SIMULATIONS AND SUBMISSION TO A GRID ENVIRONMENT (2004)

Monte Carlo simulations are increasingly used in medical physics. In scintigraphic imaging these simulations are used to model imaging systems and to develop and assess tomographic reconstruction algorithms and correction methods for improved image quantization. In radiotherapy-brachytherapy the goal is to evaluate accurately the dosimetry in complex phantoms and at interfaces of tissue, where analytic calculations have shown some limits. The main drawback of Monte Carlo simulations is their high computing time. The aim of our research is to reduce the computing time by parallelizing a simulation on geographically distributed processors. The method is based on the parallelization of the Random Number Generator (RNG) used in Monte Carlo simulations. The long serial of numbers used by the sequential simulation is split. Once the partitioning is done, a software application allows the user to generate automatically the files describing each simulation part. Finally, another software executes them on the DataGrid testbed using an API. All these steps have been made transparent for the user by providing a web page asking the user for all the parameters necessary to launch the simulation and retrieve results. Different tests have been done in order to show first, the reliability of the physical results obtained by concatenation of parallelized output data and secondly the time gained for jobs execution.
Triggers of Motion Sickness in Migraine Sufferers (2005)

The lack of association between susceptibility to movement-induced and visually induced motion sickness implies that more than one mechanism increases susceptibility to motion sickness in migraine sufferers.
Constituents of Eriobotrya japonica. A Study of Their Antiviral Properties (1992)

The CHCl3 extract of Eriobotrya japonica from an Italian source was shown to contain four new triterpene esters, namely, 23-trans-p-coumaroyltormentic acid [1], 23-cis-p-coumaroyltormentic acid [2], 3-O-trans-caffeoyltormentic acid [3], and 3-O-trans-p-coumaroylrotundic acid [4], in addition to three common ursolic acid derivatives 5, 6, and 7. An investigation of the antiviral properties of compounds 1-7 revealed that only 3 significantly reduced rhinovirus infection. The compounds were ineffective towards human immunodeficiency virus type 1 (HIV-1) and Sindbis virus replication.
An Evaluation of Endodontically Treated Vertical Root Fractured Teeth: Impact of Operative Procedures (2001)

Vertical root fractures of endodontically treated teeth are a frustrating complication that leads to extraction. The aim of the current survey was to evaluate the role of operative procedures in the etiology of this complication. A total of 154 endodontically treated vertical root fractured teeth were cleaned and washed after extraction and maintained in individual vials. Periapical radiographs before extraction, clinical findings and previous operative procedures were recorded. A post was observed in 95 teeth (61.7%), with 66 of these ending at the coronal third of the root. Most were screw posts of the Dentatus type (n = 64) and tapered cast posts (n = 14). A full crown was observed in 118 teeth, and 65 of these (55%) were extracted between 1 to 5 yr after final restoration. In 24 crowned teeth extraction was conducted within 1 yr after restoration and in 28 teeth after >5 years. It was concluded that post placement and root canal treatment are the major etiological factors for root fractures. Because signs and symptoms can appear years after the operative procedures in the root have been completed, coronal restorations would not interfere with the correct clinical diagnosis of vertical root fractures. Frequent recalls are recommended to diagnose vertical root fractures early, especially in susceptible teeth, such as premolars and mesial roots of mandibular molars.
Performances of an optical path cross-connect system and its wavelength monitoring circuit (2002)

This paper describes the performances of a newly-developed experimental optical path cross-connect system (OPXC) based on the wavelength path scheme and its wavelength monitoring circuit. The OPXC system features high levels of modularity and expandability for switching components. Exploiting planar lightwave circuit (PLC) technologies, (8/spl times/16) delivery-and-coupling-type optical switches (DC-switch) are fabricated for the 320-Gbit/s throughput OPXC system which can accommodate 16 incoming and outgoing fibers. The average fiber-to-fiber insertion loss of the DC switch is 12.6 dB and its on/off ratio is 42.1 dB. Eight wavelength-division multiplexing (WDM) signals, directly intensity-modulated at 2.5 Gbit/s, are performed to be transported over 330 km from origin to destination node via a cross-connection node in the test-bed system which simulates a 5-node network. Additionally, a novel multiwavelength simultaneous monitoring circuit for the OPXC is proposed and its performance is demonstrated through experiments.
Cyclopentadiene Elimination Reactions for the Preparation of Organoindium(III) Derivatives. Crystal and Molecular Structures of Me<sub>2</sub>In(acac), (Me<sub>3</sub>CCH<sub>2</sub>)<sub>2</sub>In(acac), (Me)(Me<sub>3</sub>CCH<sub>2</sub>)In(acac), and [Me<sub>2</sub>InNH(t-Bu)]<sub>2</sub> (2003)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCyclopentadiene Elimination Reactions for the Preparation of Organoindium(III) Derivatives. Crystal and Molecular Structures of Me2In(acac), (Me3CCH2)2In(acac), (Me)(Me3CCH2)In(acac), and [Me2InNH(t-Bu)]2O. T. Beachley,, David J. MacRae, Melvyn Rowen Churchill, Andrey Yu. Kovalevsky, and Eric S. RobirdsCite this: Organometallics 2003, 22, 24, 5152Publication Date (Web):October 25, 2003Publication History Published online25 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/om030624ohttps://doi.org/10.1021/om030624ocorrectionACS PublicationsCopyright © 2003 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views444Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (9 KB) Get e-Alertsclose Get e-Alerts
Photochemical Bissilylation of C<sub>60</sub> with Disilane<sup>1</sup> (1998)

The photochemical reaction of C60 with disilane 1 affords the adduct 2 as a bissilylated product. The unique redox properties of 2 are reported by means of differential pulse voltammetry. The compound 2 was characterized by NMR, IR, and UV−vis spectroscopies. Spectroscopic and theoretical investigation strongly support the 1,16-addition structure having C2 symmetry which results from addition at the 1,16 positions in C60. The results are reasonably accounted for by the generation of a silyl radical which is responsible for the formation of 2.
Novel antidiabetic agents (2000)

Complications, such as retinopathy, nephropathy and neuropathy caused by chronic hyperglycaemia are the greatest problem for patients with diabetes. Although normalisation of hyperglycaemia can prevent these complications, current treatment cannot completely normalise the blood glucose level in patients with Type 2 diabetes. Therefore, better hypoglycaemic agents are desired. Since hyperglycaemia in Type 2 diabetes is induced by insulin resistance, insufficient insulin secretion and increased hepatic glucose production, it is reasonable that investigations into new glucose-lowering agents have been largely dominated by studies on insulin sensitisers, insulin secretagogues and inhibitors of hepatic glucose production. This review summarises the recent patents on drugs of the above three categories.
HPV and intraepithelial neoplasia recurrent lesions of the lower genital tract: assessment of the immune system. (1998)

Our study supports the theory that immune response directed against viral antigens is one of the most important effectors in the control of HPV infections and that HPV is the cause of a systemic rather than local lesion.
Individual Tree Crown Image Analysis - A Step Towards Precision Forestry ∗ (2001)

Worldwide economy, environmental concerns, and stricter legislation governing forestry practices have put increased demands on forest managers. Riparian zone delineation, helicopter logging, plantation monitoring, selective cuts, just in time delivery, biodiversity and wildlife management are all various aspects of the same coin. The information requirements brought on by these activities is staggering. Existing information tools are inadequate and hamper the progress of forest management activities such as precision forestry. The use of high spatial resolution (10-100cm/pixel) remotely sensed images (aerial or satellite) or scanned aerial photographs, presents possibilities to analyze forested areas on an individual tree crown (ITC) basis. The Canadian Forest Service is at the forefront of research on individual tree crown based image analysis. We have developed techniques, methods and processes to separate forested from non-forested areas, delineate individual tree crowns, identify their species, and if needed, regroup them into forest stands or environmental strata. Eventually, forest managers will forgo static regroupings in favor of keeping all of the information about the individual tree crowns themselves (e.g., position, crown area, height, species, and dominance). Regrouping would be done on demand, for each specific application, if done at all. In addition, the unprecedented level of details afforded by ITC techniques should allow us to extract a variety of additional forest management information such as: snag locations, forest gap sizes and distribution, highlyvalued tree locations, detailed damage and regeneration assessments. This may also lead to more precise volume and biomass estimates and foster the use of individual tree growth models. This paper first presents some of the image analysis concepts, methods and tools behind producing ITC-based forest inventories and then, reports on some successful applications, limitations, and ongoing research.
Segmentation des muscles individuels en IRM basée sur des approches de recalage non-linéaire (2017)

Objectif : Cette etude propose un algorithme de segmentation permettant une propagation transversale entre deux coupes axiales situees aux extremites du volume d’interet et sur lesquelles les masques des muscles individuels ont ete dessines manuellement. Cette methode consiste a fusionner plusieurs champs de deformations 2D resultants de differentes approches de recalages non-lineaires estimes entre les deux coupes extremes. Le resultat de cette fusion est un champ de deformation decrivant une trajectoire dite «Lagrangienne » permettant de suivre de facon optimale les variations anatomiques des muscles.Materiels et methodes : La methode proposee dans cette etude est une methode semiautomatique permettant, a partir de la segmentation manuelle des deux coupes 2D (M0 et Mn) situees aux limites inferieures et superieures d’un volume d'interet, d’obtenir la segmentation de toutes les coupes intermediaires. Deux methodes d’interpolation et de propagation ont ete utilisees dans le but d'interpoler sur toutes les coupes du volume d'interet ces segmentations manuelles 2D. Pour l'approche d'interpolation dite «Lagrangienne », le recalage entre les segmentations manuelles inferieures et superieures du volume d'interet a ete estime et une interpolation lineaire a ete appliquee entre la transformation resultante et l'identite afin d’obtenir le masque des n coupes intermediaires manquantes. L'approche de propagation, dite « Eulerienne», etait iterative et consistait en des recalages successifs de chaque coupe IRM (image en niveau de gris) avec la coupe suivante. Les masques propages Mi ont ensuite ete generes par l’application de la combinaison des champs successifs aux masques manuels. In fine, une fusion de ces deux approches a ete utilisee afin de n’en conserver que les avantages - i.e. le suivi des deformations anatomiques locales (approche Eulerienne) et la convergence des Mi vers la coupe cible Mn (approche Lagrangienne). Notre approche a ete evaluee sur une base de donnees composee de 25 series d’images IRM de cuisse de volontaires sains. Unindice de similarite DICE (DSI) a ete utilise pour estimer la performance de notre methode au regard d’une segmentation manuelle des 4 muscles individuels du quadriceps femoris (QF).
Liquidación de sociedades conyugales (1950)

Liquidación de sociedades conyugales
Physical mapping of large DNA by chromosome fragmentation. (1988)

A technique is described for physically positioning any cloned DNA on a native or artificial Saccharomyces cerevisiae chromosome. The technique involves splitting a chromosome at a specific site by transformation with short linear molecules containing the cloned DNA at one end and telomeric sequences at the other. Recombination between the end of the linear molecules and homologous chromosomal sequences gives rise to chromosome fragments comprising all sequences distal or proximal to the mapping site depending on the orientation of the cloned DNA. The recombinant products are recovered by screening for stabilization of a suppressor tRNA on the linear molecules using a colony color assay. The cloned DNA is positioned relative to the chromosome ends by sizing the chromosomal fragments using alternating contour-clamped homogeneous electric field gel electrophoresis. Application of this technique to organisms other than S. cerevisiae and to the analysis of exogenous DNA cloned in yeast is discussed.
A novel core–shell microcapsule for encapsulation and 3D culture of embryonic stem cells (2012)

In this study, we report the preparation of a novel microcapsule of ~ 100 μm with a liquid (as compared to solid-like alginate hydrogel) core and an alginate-chitosan-alginate (ACA) shell for encapsulation and culture of embryonic stem (ES) cells in the miniaturized 3D space of the liquid core. Murine R1 ES cells cultured in the microcapsules were found to survive (> 90%) well and proliferate to form either a single aggregate of pluripotent cells or embryoid body (EB) of more differentiated cells in each microcapsule within 7 days, dependent on the culture medium used. This novel microcapsule technology allows massive production of the cell aggregates or EBs of uniform size and controllable pluripotency, which is important for the practical application of stem cell based therapy. Moreover, the semipermeable ACA shell was found to significantly reduce immunoglobulin G (IgG) binding to the encapsulated cells by up to 8.2 times, compared to non-encapsulated cardiac fibroblasts, mesenchymal stem cells, and ES cells. This reduction should minimize inflammatory and immune responses induced damage to the cells implanted <i>in vivo</i> becasue IgG binding is an important first step of the undesired host responses. Therefore, the ACA microcapsule with selective shell permeability should be of importance to advance the emerging cell-based medicine.
Aircraft Fault Diagnosis Based on Deep Belief Network (2017)

It is a great challenge to accurately and automatically diagnose different faults of aircraft using traditional method. In this paper, a new method based on deep belief network is proposed for aircraft key parts fault diagnosis. Firstly, a deep belief network is constructed with a series of pre-trained restricted Boltzmann machines for feature learning. Secondly, the highest level features learned from the DBN are fed into a softmax classifier for fault diagnosis. Finally, back-propagation learning algorithm is adopted to fine-tune the deep model parameters to further improve the diagnosis accuracy. The proposed method is applied to analyze the experimental rolling bearing signals. The results show that the proposed method is more effective and robust than other traditional methods.
Dual Drug Delivery of Sorafenib and Doxorubicin from PLGA and PEG-PLGA Polymeric Nanoparticles (2018)

Combinatorial drug delivery is a way of advanced cancer treatment that at present represents a challenge for researchers. Here, we report the efficient entrapment of two clinically used single-agent drugs, doxorubicin and sorafenib, against hepatocellular carcinoma. Biocompatible and biodegradable polymeric nanoparticles provide a promising approach for controlled drug release. In this study, doxorubicin and sorafenib with completely different chemical characteristics were simultaneously entrapped by the same polymeric carrier, namely poly(d,l-lactide-<i>co</i>-glycolide) (PLGA) and polyethylene glycol-poly(d,l-lactide-<i>co</i>-glycolide) (PEG-PLGA), respectively, using the double emulsion solvent evaporation method. The typical mean diameters of the nanopharmaceuticals were 142 and 177 nm, respectively. The PLGA and PEG-PLGA polymers encapsulated doxorubicin with efficiencies of 52% and 69%, respectively, while these values for sorafenib were 55% and 88%, respectively. Sustained drug delivery under biorelevant conditions was found for doxorubicin, while sorafenib was released quickly from the PLGA-doxorubicin-sorafenib and PEG-PLGA-doxorubicin-sorafenib nanotherapeutics.
Virtue and Knowledge: An Introduction to Ancient Greek Ethics (1994)

This book focuses on the concept of virtue, and in particular on the virtue of wisdom or knowledge, as it is found in the epic poems of Homer, some tragedies of Sophocles, selected writings of Plato, Aristotle, and the Stoic and Epicurean philosophers. The key questions discussed are the nature of the virtues, their relation to each other, and the relation between the virtues and happiness or well-being. There has been renewed interest recently in the concept of virtue. The value of William Prior's book is that it provides the background and interpretive framework to make classical works on ethics, such as Plato's Republic and Aristotle's Nicomachean Ethics, accessible to readers with no training in the classics.
Idiopathic pulmonary fibrosis associated with high-titer antibodies against nuclear ribonucleoprotein (nRNP): Report of 3 cases (1986)

Article Idiopathic pulmonary fibrosis associated with high-titer antibodies against nuclear ribonucleoprotein (nRNP): Report of 3 cases was published on November 1, 1986 in the journal Journal of Osteopathic Medicine (volume 86, issue 11).