gebhart/patrepeval huggingface dataset:
[Morphologic parameters of blood platelets and dysmorphic erythrocyturia in chronic glomerulonephritis]. (1997)

Dysmorphic erythrocyturia is known as an attribute of glomerular bleeding. During chronic glomerulonephritis the morphological changes of blood platelets were also observed. The subject of our study was to indicate if the common mechanism leading to blood platelets polymorphology and dysmorphic erythrocytes origination in chronic glomerulonephritis is possible. We estimate the count of blood platelets (PLT), mean platelets volume (MPV), platelet distribution weight (PDW) and platelets crit (PCT) in peripheral blood of 46 patients with chronic glomerulonephritis with dysmorphic erythrocyturia (26 with renal sufficiency and 20 with renal insufficiency) and 32 healthy volunteers. The dysmorphic erythrocyturic erythrocytes were examined in first morning urine. We have not demonstrated the correlation of changes in blood platelets morphology with percent dysmorphic erythrocytes in urine. The results of our investigations do not confirm exactly the common mechanism of the morphological changes which were observed. Minimal changes of the blood platelets parameters may be the results of changes in structure of phospholipids platelets membrane as well as less activation of platelets membrane receptors-GP Ia/IIb and GP Ic/IIa.
Indexing the Java API Using Source Code (2008)

The basic idea behind software reuse is that software developers use reusable components found in software repositories to reduce the amount of code that has to be written and so increase productivity. A problem arises, however, if the repository is too big - it becomes difficult to find relevant components. What is needed is an effective means to query repositories. Most approaches to developing such means involves creating a good index to which the queries can be applied. Developing a good index requires identifying the relevant information on which to base the index. In this paper, we present the results of a project that used source code as the basis for the index.
Characteristics of the β-Adrenergic Receptor Complex in the Epicardial Border Zone of the 5-Day Infarcted Canine Heart (1995)

Defects in multiple components of the membrane beta-adrenergic receptor complex were identified in the EBZ of the 5-day infarcted canine heart. This constellation of abnormalities would be predicted to impair functional beta-adrenergic responsiveness and contribute to the defect in isoproterenol-dependent stimulation of the L-type calcium current in myocytes isolated from this tissue.
Direct homogeneous phosphoroimmunoassay for carbamazepine in serum. (1986)

In this "phosphoroimmunoassay," a phosphorescent label is used: erythrosin (tetraiodofluorescein). Its long-lived phosphorescence was detected after pulsed excitation in a time-resolved luminescence spectrometer. To achieve convenient open-atmosphere phosphorimetry in liquid solution at room temperature, we used sodium sulfite as an "in situ" chemical deoxygenator, to eliminate oxygen quenching of the excited triplet state. Time-resolved detection allows for complete rejection of short-lived background signals, including those from fluorescent or light-scattering components of biological fluids that can interfere in fluoroimmunoassays. We chose the antiepileptic drug carbamazepine (CBZ) and its active metabolite CBZ-10, 11-epoxide (CBZE) to demonstrate the development and validation of nonseparation assays based on quenching the phosphorescence of erythrosin-labeled drug upon binding to antibody. These two compounds cross reacted equally with the antiserum used; hence, we measured the activity of both in patients' sera. Alternatively, simple pre-treatment of the sample with acid destroys CBZE immunoreactivity and enables specific assay of CBZ.
Novel rearrangement of pyrazole N-imines with acetic anhydride. (1976)

2-Amino-1, 3-dimethylindazolium mesitylenesulfonate (I) was allowed to react with a large excess of acetic anhydride in the presence of anhydrous sodium acetate to give the unexpected rearrangement products, 3-acetoxymethyl-1-methylindazole (IV), 3-acetylaminomethyl-1-methylindazole (V) and the deaminated product, 1, 3-dimethylindazole (II), and the desired product, pyrazolo [2, 3-b] indazole derivative (III), could not be obtained. Likewise, the same reactions of 2-amino-1, 3, 5-trimethylpyrazolium mesitylenesulfonate (VII) and 2-amino-1, 3, 4, 5-tetramethylpyrazolium mesitylenesulfonate (VIII) gave the rearrangement products, 5-acetoxymethyl-1, 3-dimethylpyrazole (IX) and 5-acetoxymethyl-1, 3, 4-trimethylpyrazole (X), respectively. This is the first example of a rearrangement reaction of aromatic amine N-imine with acid anhydride. The desired product (III) was obtained by the reaction of 2-amino-1-methylindazolium mesitylenesulfonate (XIV) with acetylacetone in the presence of triethylamine, followed by oxidation with lead tetraacetate.
Treatment of moderate to severe plaque psoriasis with concomitant efalizumab and narrow-band ultraviolet B phototherapy. (2008)

Combination of efalizumab and NB-UVB followed by efalizumab monotherapy was effective and well tolerated, this warranting further investigation.
Free-standing, optically pumped, GaN∕InGaN microdisk lasers fabricated by photoelectrochemical etching (2004)

GaN-based, mushroom-shaped microdisk lasers were fabricated using band-gap selective photoelectrochemical etching. The optically pumped microdisks had well-defined, distinct modes at excitation powers ranging from about 8to16W∕cm2. Modal linewidths of 0.09nm were reported, which was near the resolution of the measurement equipment. Quality factors for the microdisks were &gt;4600. The observed lasing threshold was 12.1W∕cm2. At higher excitation powers, heating effects and degradation were observed in the optical response of the microdisks.
Capacitive detection of humans for safety in industry - a numerical and experimental investigation (1998)

The detection of humans for their own safety in an industrial environment is vital, especially with increases in the flexibility and velocity of automated working machines. A capacitive detector for the detection of humans in guarded zones has been designed. An electromagnetic model accounting for bodies of different permittivity in the vicinity of the sensor is described. Numerical calculations based on the electromagnetic model have been made and experimental measurements have been taken. An example shows how the electromagnetic model can be used to model the output of the person detector.
Static and dynamic properties of unidirectional CFRP laminates with flexible interphase (2002)

In this study, a flexible interphase than matrix resin is studied. The fabrication method of unidirectional CFRP laminates with flexible fiber/matrix interphase has been established. The influence of the flexible interphase thickness on the flexural modulus and strength are experimentally investigated. The influence on the vibration properties are also investigated. It has been concluded that the flexible interphase with the optimized thickness could improve both the static and dynamic properties.
Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse (2001)

Transgenic Tg.AC (v-Ha-ras ) mice develop skin tumors in response to specific carcinogens and tumor promoters. The Tg.AC mouse carries the coding sequence of v-Ha ras, linked to a zeta-globin promoter and an SV40 polyadenylation signal sequence. The transgene confers on these mice the property of genetically initiated skin. This study examines the age-dependent sensitivity of the incidence of skin papillomas in Tg.AC mice exposed to topically applied 12-O:-tetradecanoylphorbol-13-acetate (TPA) treatment, full thickness skin wounding or UV radiation. Skin tumor incidence and multiplicity were strongly age-dependent, increasing with increasing age of the animal when first treated at 5, 10, 21 or 32 weeks of age. Furthermore, the temporal induction of transgene expression in keratinocytes isolated from TPA-treated mouse skin was also influenced by the age of the mice. Transgene expression was seen as early as 14 days after the start of TPA treatment in mice that were 10-32 weeks of age, but was not detected in similarly treated 5-week old mice. When isolated keratinocytes were fractionated by density gradient centrifugation the highest transgene expression was found in the denser basal keratinocytes. Transgene expression could be detected in the denser keratinocyte fraction as early as 9 days from start of TPA treatment in 32-week old mice. Using flow cytometry, a positive correlation was observed between expression of the v-Ha-ras transgene and enriched expression of the cell surface protein beta1-integrin, a putative marker of epidermal stem cells. This result suggests that, in the Tg.AC mouse, an age-dependent sensitivity to tumor promotion and the correlated induction of transgene expression are related to changes in cellular development in the follicular compartment of the skin.
Erratum: “Inplane Flexural Vibrations of Circular Rings” (Journal of Applied Mechanics, 1969, 36, pp. 620–625) (1970)

The following COITeetiolls are to be made in thb paper:The right~hand side of Cqlllltioll (1) HliolllJ cont.llinfl in the numerator.2 The right-halld ~ide of equatioll (4) ~h()lIld rend HI/H, oc/>/u(} instead of H[,! R2 (U 2 1l/U0 1 + uw/O(}).TIl!! lat.t(~1' eOl'rcsponds to the case where deforlIlnt.ioneffect is lleglect.e(1.::\ The first terlll of the eoerlicient. of [(, ill equat.ion(17) ~ho\lld read n 4 S, instead of nOS,.Sillce t.hese were only oll\bsions 01' misprint.s,the rest of the eqllat.ionsand all the reslilts pl'escn ted I.herein remain perfect.ly
Genetic basis for the evolution of vertebrate mineralized tissue (2004)

Mineralized tissue is vital to many characteristic adaptive phenotypes in vertebrates. Three primary tissues, enamel (enameloid), dentin, and bone, are found in the body armor of ancient agnathans and mammalian teeth, suggesting that these two organs are homologous. Mammalian enamel forms on enamel-specific proteins such as amelogenin, whereas dentin and bone form on collagen and many acidic proteins, such as SPP1, coordinately regulate their mineralization. We previously reported that genes for three major enamel matrix proteins, five proteins necessary for dentin and bone formation, and milk caseins and salivary proteins arose from a single ancestor by tandem gene duplications and form the secretory calcium-binding phosphoprotein (SCPP) family. Gene structure and protein characteristics show that SCPP genes arose from the 5' region of ancestral sparcl1 (SPARC-like 1). Phylogenetic analysis on SPARC and SPARCL1 suggests that the SCPP genes arose after the divergence of cartilaginous fish and bony fish, implying that early vertebrate mineralization did not use SCPPs and that SPARC may be critical for initial mineralization. Consistent with this inference, we identified SPP1 in a teleost genome but failed to find any genes orthologous to mammalian enamel proteins. Based on these observations, we suggest a scenario for the evolution of vertebrate tissue mineralization, in which body armor initially formed on dermal collagen, which acted as a reinforcement of dermis. We also suggest that mammalian enamel is distinct from fish enameloid. Their similar nature as a hard structural overlay on exoskeleton and teeth is because of convergent evolution.
Gravidity-Dependent Production of Antibodies That Inhibit Binding of<i>Plasmodium falciparum</i>-Infected Erythrocytes to Placental Chondroitin Sulfate Proteoglycan during Pregnancy (2001)

During pregnancy, Plasmodium falciparum-infected erythrocytes sequester in the placenta by adhering to chondroitin 4-sulfate, creating a risk factor for both the mother and the fetus. The primigravidae are at higher risk for placental malaria than the multigravidae. This difference in susceptibility has been attributed to the lack of antibodies that block the adhesion of infected erythrocytes to placental chondroitin 4-sulfate in primigravid women. However, recent results show that many primigravidae at term have antibody levels similar to those of multigravidae, and thus the significance of antiadhesion antibodies in providing protection against malaria during pregnancy remains unclear. In this study, we analyzed plasma samples from women of various gravidities at different gestational stages for antiadhesion antibodies. The majority of women, regardless of gravidity, had similar levels of antibodies at term. Most primigravidae had low levels of or no antiadhesion antibodies prior to ~20 weeks of pregnancy and then produced antibodies. Multigravidae also lacked antibodies until ~12 weeks of pregnancy, but thereafter they efficiently produced antibodies. In pregnant women who had placental infection at term, higher levels of antiadhesion antibodies correlated with lower levels of placental parasitemia. The difference in kinetics of antibody production between primigravidae and multigravidae correlated with the prevalence of malaria in these groups, suggesting that antibodies are produced during pregnancy in response to placental infection. The early onset of efficient antibody response in multigravidae and the delayed production to antibodies in primigravidae appear to account for the gravidity-dependent differential susceptibilities of pregnant women to placental malaria.
Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers (2015)

As a type of secreted membrane vesicle, exosomes are an emerging mode of cell-to-cell communication. Yet as exosome samples are commonly contaminated with other extracellular vesicles, the biological roles of exosomes in regulating immunity and promoting oncogenesis remain controversial. Wondering whether existing methods could distort our view of exosome biology, we compared two direct methods for imaging extracellular vesicles and quantified the impact of different production and storage conditions on the quality of exosome samples. Scanning electron microscopy (SEM) was compared to transmission electron microscopy (TEM) as alternatives to examine the morphology of exosomes. Using SEM, we were able to distinguish exosomes from other contaminating extracellular vesicles based on the size distribution. More importantly, freezing of samples prior to SEM imaging made it more difficult to distinguish exosomes from extracellular vesicles secreted during cell death. In addition to morphology, the quality of RNA contained within the exosomes was characterized under different storage conditions, where freezing of samples also degraded RNA. Finally, we developed a new flow cytometry approach to assay transmembrane proteins on exosomes. While high-copy-number proteins could be readily detected, detecting low-copy-number proteins was improved using a lipophilic tracer that clustered exosomes. To illustrate this, we observed that exosomes derived from SKBR3 cells, a cell model for human HER2+ breast cancer, contained both HER1 and HER2 but at different levels of abundance. Collectively, these new methods will help to ensure a consistent framework to identify specific roles that exosomes play in regulating cell-to-cell communication.
Phenotype Recognition with Combined Features and Random Subspace Classifier Ensemble (2011)

The characteristics of curvelet transform of being multiscale and multidirectional suit the description of microscopy images very well. It is empirically demonstrated that the curvelet-based feature is clearly preferred to wavelet-based feature for bioimage descriptions. The random subspace ensemble of MLPs is much better than a number of commonly applied multi-class classifiers in the investigated application of phenotype recognition.
Novel Thermoresponsive Polymers Having Biodegradable Phosphoester Backbones (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTNovel Thermoresponsive Polymers Having Biodegradable Phosphoester BackbonesYasuhiko Iwasaki, Chookaet Wachiralarpphaithoon, and Kazunari AkiyoshiView Author Information Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan, and Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan Cite this: Macromolecules 2007, 40, 23, 8136–8138Publication Date (Web):October 12, 2007Publication History Received13 July 2007Revised24 September 2007Published online12 October 2007Published inissue 1 November 2007https://pubs.acs.org/doi/10.1021/ma0715573https://doi.org/10.1021/ma0715573rapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views2063Altmetric-Citations110LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biomaterials,Polymers,Solution chemistry,Thermal properties,Thermoresponsive polymers Get e-Alerts
Bioartificial Sinus Node Constructed via In Vivo Gene Transfer of an Engineered Pacemaker HCN Channel Reduces the Dependence on Electronic Pacemaker in a Sick-Sinus Syndrome Model (2006)

The results of the present study provide important functional and mechanistic insights into cardiac automaticity and have further refined an HCN gene-based therapy for correcting defects in cardiac impulse generation.
Retargeting of a T cell line by anti MAGE-3/HLA-A2 alpha beta TCR gene transfer. (2000)

We conclude that TCR gene transfer is possible and it represents a powerful therapeutic tool for the genetical modification of T calls of patients sullering from cancer.
Model of a MEMS sensor using a common gate MOSFET differential amplifier (2006)

The design, modelling and feasibility of a MEMS sensor based on a common gate metal-oxide-semiconductor field effect transistors (MOSFET) differential amplifier is presented. A pair of adjacent MOSFETs shares a common gate electrode that is suspended in a torsional configuration over the transistor gate regions. Rotation of the common gate alters the relative spacing between the gate tips and the substrate changing the gate capacitance of each transistor. Connection of the transistor pair in a differential readout configuration generates a differential current flow through the MOSFET pair. This sensor integrates transduction and amplification as movement of the MEMS gate modulates the relative gate capacitance and drain current of each transistor. The differential configuration provides a high common mode rejection ratio and the estimated sensitivity is 68 µA (fF−1) and the responsivity of the sensor is 2.2 mV/degree.
3D Hollow Nanostructures as Building Blocks for Multifunctional Plasmonics (2013)

We present an advanced and robust technology to realize 3D hollow plasmonic nanostructures which are tunable in size, shape, and layout. The presented architectures offer new and unconventional properties such as the realization of 3D plasmonic hollow nanocavities with high electric field confinement and enhancement, finely structured extinction profiles, and broad band optical absorption. The 3D nature of the devices can overcome intrinsic difficulties related to conventional architectures in a wide range of multidisciplinary applications.
Anti-CD4: An Alternative Way to Inhibit HIV Infection (2016)

Human Immunodeficiency Virus (HIV) initiates infection in host T-cells by binding with CD4 molecules on the cell surface, otherwise known as the primary cell receptor. Human CD4 molecules may therefore be able to assist the host immune system in mounting an immune defense, in controlling immune homeostasis and during immune monitoring. Indeed, anti-CD4 reagents could be used to perturb the HIV–CD4 interaction and thereby directly neutralize and inhibit HIV through surface glycoproteins. At present, various anti-CD4 antibodies have been shown to block HIV-1 infection with genotype-broad and highly effective features, some of which have been further tested in clinical trials. Here, we review some of the more potent anti-CD4 antibodies isolated to date, and focus on the molecular insights gained from the understanding of the binding of monoclonal antibodies (mAbs) to the CD4 D1 (mAb 15A7) and D2 (Ibalizumab) domains. These salient points may aid in the design of better anti-CD4 reagents for HIV treatment.
NOx Reduction in Natural Gas RI Augmented Large Bore Four-Stroke SI Engines (2011)

<div class="section abstract"><div class="htmlview paragraph">A preliminary study is made of the effectiveness of internally generated “Radical Ignition (RI) species” for NOx reduction in a NG (natural gas) Spark-Ignition (SI) 4-stroke test engine operating under lean fuel conditions at a typical SI compression ratio. The study includes both experimental and simulation analysis components. Investigated in this study is the potential for augmenting SI using a controlled presence of these RI species. The aim of their use is to lower the heat required for flame propagation under leaner than otherwise attainable fuel conditions. This lowers the NOx production. The primary generating site for these species is a set of passive mini-chambers located within the cylinder head. A modified single cylinder SI engine is used for the experimental studies. The simulation involves the chemical-kinetics of 32 species and 97 chemical reactions: solved simultaneously within the mini and main chambers as these chambers interact with each other, with the engine housing and with the manifold (exchanging energy, momentum, mass and chemical species). The study suggests that significant NOx reductions can be accomplished.</div></div>
Dipyridamole in chronic stable angina pectoris. A randomized, double blind, placebo-controlled, parallel group study (2001)

In patients with chronic stable angina treated with regular antianginal background medication, the use of oral dipyridamole is safe and well tolerated. Antianginal and antiischaemic efficacy, as assessed by exercise testing, is comparable to placebo, except for a beneficial effect on time to ischaemia after 2 months, totally attributable to patients with lower exercise tolerance at study entry.
The Central Role and Challenges of Integrated Production Operations (2006)

Abstract This technical paper endeavours to describe the central role of Integrated Production Operations (IPO) in exploiting hydrocarbon reserves through the production phase of an asset. It provides definition of the key characteristics of IPO, sets out business case criterion for investment in IPO, challenges current industry positions and paradigms on future field management and provides a generic roadmap for operators seeking to be early adopters of IPO as a platform around which to organize their Digital Oil Field of the Future 1 (DOFF) initiatives.