gebhart/patrepeval huggingface dataset:
Multi-layered ontology-based user profiles and semantic social networks for recommender systems (2006)

Abstract. This paper describes a strategy that automatically clusters ontologybased user profiles taking into account their common interests for domain concepts. The obtained semantic clusters are used to identify similarities among individuals at multiple semantic preference layers, and to define emergent, layered social networks that can be applied in collaborative and recommender systems. As an applicative development of our method, we have experimented with building a personalized information retrieval model that provides ranked item lists based on the existing concept clusters and multi-layered user networks. 1
[Changes in the efferent impulsation in the vagus nerves during the metastasis of Lewis lung carcinoma in mice]. (1989)

In electrophysiological experiments the reflectory reaction of the efferent impulsation in the vagus nerve elicited by the stimulation of the lung and airway receptors was studied in the mice with the lung Lewis carcinoma. It has been established that the extension of the metastatic process was accompanied by the disturbances in the relationships of the central cholin- and dopaminergic mechanisms of the respiratory nervous regulation with hyperactivation of the former and depression of the latter. The use of the neurotropic drugs of the central action normalizing or disturbing these interrelations inhibits or stimulates, respectively, the metastatic process.
The angiopoietin–tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis (2001)

These results suggest that adult coronary artery contains Ang1-Tie2 components that enhance endothelial cell survival to help maintain the normal integrity of the coronary artery endothelium.
Infection of Soybean Seed by <i>Fusarium graminearum</i> and Effect of Seed Treatments on Disease Under Controlled Conditions (2010)

Fusarium graminearum causes seed decay and damping-off of soybean. This study evaluated the effect of inoculum density of F. graminearum, temperature, and fungicide seed treatments on disease development. To determine the optimum conditions for disease development, individual soybean seed was inoculated with 100 μl of a suspension of 2.5 × 10<sup>2</sup>, 2.5 × 10<sup>3</sup>, 2.5 × 10<sup>4</sup>, or 2.5 × 10<sup>5</sup> macroconidia/ml in a rolled-towel assay at temperatures of 18, 22, and 25°C. Inoculum concentrations of 2.5 × 10<sup>4</sup> macroconidia/ml or higher were necessary for optimum disease development at all temperatures. The efficacy of captan, fludioxonil, mefenoxam + fludioxonil, azoxystrobin, trifloxystrobin, and pyraclostrobin as seed treatments was then evaluated with the same assay at 2.5 × 10<sup>4</sup> and 2.5 × 10<sup>5</sup> macroconidia/ml. Seed treated with captan at 61.9 g a.i. or fludioxonil at 2.5 or 5.0 g a.i. per 100 kg developed smaller lesions than other seed treatments and the nontreated control. Based on these results, there are limited choices in fungicide seed treatments for managing this seedling disease, and it is possible that shifts in seed treatment products may have played a role in the recent emergence of this soybean pathogen.
Cytochrome <i>c</i> oxidase deficiency in leigh syndrome (1987)

We studied 6 mitochondrial enzymes in crude extracts and isolated mitochondria from 5 children with pathologically proven subacute necrotizing encephalomyelopathy (Leigh syndrome). Samples were taken from brain (5 patients), skeletal muscle (4 patients), liver (4 patients), kidney (4 patients), heart (1 patient), and cultured fibroblasts (3 patients). An isolated defect of cytochrome c oxidase (COX) activity was found in brain (decrease of activity to 15 to 39% of the normal mean), muscle (9 to 20%), kidney (1 to 67%), and in the 1 available heart (4%) from a patient with cardiopathy. COX activity was also decreased in liver of 3 patients (2 to 13% of normal) and in cultured fibroblasts of 2 patients (18 and 27%), but it was normal in both liver and fibroblasts from 1 patient. Immunotitration using polyclonal antibodies against human heart COX showed essentially normal amounts of cross-reacting enzyme protein in various tissues from different patients. Electrophoresis of COX immunoprecipitated from brain mitochondrial extracts showed normal patterns of COX subunits in 2 patients. This study confirms the theory that COX deficiency is an important cause of Leigh syndrome.
Delphi 4 Bible (1998)

This manual offers everything needed to create Windows applications with the rapid application development tool, Delphi 3. It contains advice on programming with visual components, forms, properties and events. With guidelines for creating sleek user interfaces with Delphi's Visual Component Library of menus, buttons, toolbars, status panels, multi-page dialogue boxes and text controls, it presents coverage of application development for relational database systems, graphics, communications and a variety of other uses. By studying the applications on the book's CD-ROM, programmers can observe how Delphi is used to create commercial quality Windows' applications.
Quantitative-Qualitative Friction Ridge Analysis (1999)

A thumb print left at the scene of a grisly murder. Fingerprints taken from a getaway car used in a bank robbery. A palm print recovered from the shattered glass door of a burglarized home. Indeed, where crimes are committed, careless perpetrators will invariably leave behind the critical pieces of evidence most likely in the form of fingerprints n
Gleason Score and Lethal Prostate Cancer: Does 3 + 4 = 4 + 3? (2009)

PURPOSE Gleason grading is an important predictor of prostate cancer (PCa) outcomes. Studies using surrogate PCa end points suggest outcomes for Gleason score (GS) 7 cancers vary according to the predominance of pattern 4. These studies have influenced clinical practice, but it is unclear if rates of PCa mortality differ for 3 + 4 and 4 + 3 tumors. Using PCa mortality as the primary end point, we compared outcomes in Gleason 3 + 4 and 4 + 3 cancers, and the predictive ability of GS from a standardized review versus original scoring. PATIENTS AND METHODS Three study pathologists conducted a blinded standardized review of 693 prostatectomy and 119 biopsy specimens to assign primary and secondary Gleason patterns. Tumor specimens were from PCa patients diagnosed between 1984 and 2004 from the Physicians' Health Study and Health Professionals Follow-Up Study. Lethal PCa (n = 53) was defined as development of bony metastases or PCa death. Hazard ratios (HR) were estimated according to original GS and standardized GS. We compared the discrimination of standardized and original grading with C-statistics from models of 10-year survival. Results For prostatectomy specimens, 4 + 3 cancers were associated with a three-fold increase in lethal PCa compared with 3 + 4 cancers (95% CI, 1.1 to 8.6). The discrimination of models of standardized scores from prostatectomy (C-statistic, 0.86) and biopsy (C-statistic, 0.85) were improved compared to models of original scores (prostatectomy C-statistic, 0.82; biopsy C-statistic, 0.72). CONCLUSION Ignoring the predominance of Gleason pattern 4 in GS 7 cancers may conceal important prognostic information. A standardized review of GS can improve prediction of PCa survival.
The Influence of Monomers upon Microemulsions with Short Chain Cosurfactant (2001)

Several monomers (i.e., acrylonitrile (ACN), ethyl acrylate (EtA), acrylate of 2 ethylhexyl (EHA), butyl acrylate (BuA), vinyl acetate (VAc), methyl methacrylate (MMA) and styrene (St)) were investigated in order to study their capacities to form microemulsions. The surfactant was nonyl phenol ethoxylate with 25 moles ethylene oxide and ethanol was used as the cosurfactant. The phase diagrams prove that the capacity for microemulsion formation varies in the following sequence: ACN = EtA > VAc > BuA > MMA > St > EHA. Conductometric and refractometric studies allowed us to evidence the formation of microemulsions with W/O, bicontinuous or O/W structure. Fluorescence studies give interesting informations on the stabilization capacity of the monomers dispersed by interaction with hydrophobic chain of the cosurfactant. H-NMR studies suggest that the monomers in microemulsions lie in regions with various polarities as function of their chemical nature. In polymerization initiated with benzoyl peroxide the minimum conversions were obtained in zones of composition where the initial microemulsions possess a bicontinuous microstructure. The reactions of degradative transfer of the increasing macroradicals account for these conversion modifications. For initiation with ammonium persulphate, its rate of decomposition depends on its ability to displace the proton bonded to the substituted vinylic carbon of the monomer. The productivity of this initiator varies within the sequence MMA > EtA > BuA > St > ACN > VAc. The consumption of the initiator, as induced by the monomer, depends on its chemical nature and on the solubilization site of the microemulsions.
Mercuric ion-resistance operons of plasmid R100 and transposon Tn501: the beginning of the operon including the regulatory region and the first two structural genes. (1984)

The mercuric ion-resistance operons of plasmid R100 (originally from Shigella) and transposon Tn501 (originally from a plasmid isolated in Pseudomonas) have been compared by DNA sequence analysis. The sequences for the first 1340 base pairs of Tn501 are given with the best alignment with the comparable 1319 base pairs of R100. The homology between the two sequences starts at base 58 after the end of the insertion sequence IS-1 of R100. The sequences include the transcriptional regulatory region, and the homology is particularly strong in regions just upstream from potential transcriptional initiation sites. The trans-acting regulatory gene merR consists of 180 base pairs in both cases and codes for a highly basic polypeptide of 60 amino acids, which is also rich in serine. The Tn501 and R100 merR genes differ in 25 of the 180 base positions, and the resulting polypeptides differ in seven amino acids. The regulatory region before the major transcription initiation site contains potential -35 and -10 sequences and dyad symmetrical sequences, which may be the merR binding sites for transcriptional regulation. The first structural gene, merT, encodes a highly hydrophobic polypeptide of 116 amino acids. The R100 and Tn501 merT genes differ in 17% of their positions, leading to 14 (12%) amino acid changes. This region had previously been shown to encode a protein governing membrane transport of mercuric ions. The second structural gene, merC, would give a 91 amino acid polypeptide with a hydrophobic amino-terminal segment. The Tn501 and R100 merC genes differ at 37 base positions, leading to 10 amino acid changes.
Evaluation of the Risk of Spreading Fire Blight in Apple Orchards with a Mechanical String Blossom Thinner (2009)

The risk of spreading fire blight in apples after mechanical thinning with a rotating string blossom thinner was evaluated in field and potted-tree experiments. In the field experiment, using the mechanical thinner on noninoculated trees immediately after operating the equipment on inoculated trees significantly ( P < 0.01) increased fire blight incidence resulting in 90 ± 20.01 (mean ± SE) infected shoots compared with 23.5 ± 8.97 diseased shoots in similar trees that were not thinned mechanically. A similar result was obtained in greenhouse experiments whereby healthy apple plants positioned adjacent to diseased plants before the group was subjected to the mechanical thinner developed more than twice the number of infected shoots as that on similar plants that were not thinned. These results indicate that under conditions conducive to infection, the mechanical blossom thinner significantly increases the risk of spreading Erwinia amylovora . The use of the thinner should therefore be limited to orchards with no history of disease in the last 3 years and on days when predicted weather is not suitable for tree infection by E. amylovora ; otherwise, a severe fire blight epidemic could develop in the orchard.
Development of pallet pattern placement strategies in robotic palletisation (2014)

Purpose – This paper presents an investigation on the development of different pattern placement strategies in robotic palletisation of box packages in the packaging industry with practical implementations for one, two, four and five block patterns with the aim of improving the operational efficiency in robotic palletisation. Design/methodology/approach – The work involves considering the gripper design and maximum number of picks and various process parameters that affect the robotic implementation of pallet patterns and develops a methodology to form different patterns for a given pallet size. Findings – The proposed methodology represents an efficient approach for pallet pattern implementation and results in reduced number of placements required for a given number of boxes per layer and reduced time for palletisation. Originality/value – The paper introduces a novel technique for pallet loading problem (PLP) considering the physical aspects and restrictions encountered when using the robot and the gripper size to generate the pattern on the pallet. Traditional solutions of PLP do not consider these aspects in pattern placements.
Magnetic and transport properties of magneto-anisotropic nanocomposites for controlled drug delivery (2015)

Biodegradable polymeric film composites consisting of chitosan (Cht) and poly(3-hydroxybutyrate) (PHB) have been produced and used to encapsulate colloidal magnetite nanoparticles (MNPs) and a drug (dipyridamole). The magnetic organization of the MNPs induced by the exposure of the films to external magnetic fields was analyzed using ferromagnetic resonance and electron microscopy. A calculation of the relative abundance of aggregated nanoparticles showed that more than 14% of the particles were aggregated at total particle concentrations ranging from 3 to 8 mass %. Modification of the PHB-Cht composite matrix by nanoparticles has been proven to evoke changes in drug release kinetics, since the particles formed ordered magneto-anisotropic structures when exposed to external magnetic fields. The highest rate of transfer by diffusion was observed in the case of a nonisotropic matrix in which the orientation of particle aggregates coincided with the direction of the diffusion flux; the rate of drug release was the lowest in anisotropic matrices of biodegradable magneto-anisotropic nanocomposites with particle orientation perpendicular to the direction of diffusion. The physical reasons for the dependence of the release kinetics on the magnetic anisotropy of the samples are discussed. The results of the present study are indicative of the possibility of creating a new generation of therapeutic systems for the targeted delivery and sustained release of drugs controlled by a magnetic field.
ChemInform Abstract: SULFUR COMPOUNDS IN PETROLEUM. II. 6,11‐DIHYDRODIINDENO(1,2‐B:1′,2′‐D)THIOPHENES (1983)

Abstract Die Titelverbindung (VIa) wird einmal aus dem Dithiindicarbonsäureester (Ib) über das Thiophen (IIb) (S‐Eliminierungen dieses Typs lassen sich mit Peroxyessigsäure in CH,CI2 durchführen), (llc), (IId), den Indenothiophencarbonsäureester (III), die Säure (IV) und das Dion (V), zum anderen aus (Ia) über (IIe) und das Diol (VII) dargestellt.
Studies on the Hydrazinolysis of Glycoproteins (1976)

Hydrazinolysis of porcine thyroglobulin glycopeptides and of pineapple stem bromelain [EC 3.4.22.4] permitted the isolation of almost intact carbohydrate chains of these glycoproteins. On the basis of permethylation analyses of the released oligosaccharides after reduction with NaBH4, the core structures of Unit A-type and Unit B-type carbohydrate chains of porcine thyroglobulin were deduced to be Manalpha1 leads to 6[Manalpha1 leads to 3]Manbeta1 leads to 4GlcNAcbeta1 leads to 4[Ralpha1 leads to 6]GlcNAc leads to Asn (Unit A-type, R=H; Unit B-type, R=Fuc), and that of bromelain was found to be Manalpha1 leads to 6[R'1 leads to 2]Manbeta1 leads to 4GlcNAcbeta1 leads to 4[R1 leads to 3]GlcNAc leads to Asn (R'=Xylbeta and R=Fucalpha, or R'=Fucalpha and R=Xylbeta). From these results, it appears that the hydrazinolysis method is applicable to wide variety of glycoproteins which have an N-glycosylamine linkage between the carbohydrate and peptide moieties, regardless of the type of linkage to the most proximal N-acetylglucosamine residue which is bound to asparagine.
NEW METHODS OF SPLITTING PYRIMIDINES. V. THE ACTION OF OXYGEN PLUS FERROUS SALTS ON THYMINE UNDER THE INFLUENCE OF LIGHT (1924)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNEW METHODS OF SPLITTING PYRIMIDINES. V. THE ACTION OF OXYGEN PLUS FERROUS SALTS ON THYMINE UNDER THE INFLUENCE OF LIGHTLawrence W. BassCite this: J. Am. Chem. Soc. 1924, 46, 1, 190–192Publication Date (Print):January 1, 1924Publication History Published online1 May 2002Published inissue 1 January 1924https://doi.org/10.1021/ja01666a025RIGHTS & PERMISSIONSArticle Views21Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (218 KB) Get e-Alerts Get e-Alerts
Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases (2021)

T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells, we study epitope-specific T cell responses of 99 convalescent coronavirus disease 2019 (COVID-19) cases. The SARS-CoV-2 proteome is probed using 1,925 peptides spanning the entire genome, ensuring an unbiased coverage of human leukocyte antigen (HLA) alleles for class II responses. For HLA class I, we study an additional 5,600 predicted binding epitopes for 28 prominent HLA class I alleles, accounting for wide global coverage. We identify several hundred HLA-restricted SARS-CoV-2-derived epitopes. Distinct patterns of immunodominance are observed, which differ for CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and antibodies. The class I and class II epitopes are combined into epitope megapools to facilitate identification and quantification of SARS-CoV-2-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells.
Direct Production and Purification of T7 Phage Display Cloned Proteins Selected and Analyzed on Microarrays (2006)

Phage display technology has emerged into a powerful tool for identifying proteins with specific binding properties. This technology adds amino acid sequences to the carboxy terminus of a phage capsid protein, thus generating a fusion protein displayed on the surface of the phage. Here, we have developed a high-throughput strategy to synthesize purified protein that solves many of the problems associated with crude phage lysates. Phage DNA was used as a template for a nested PCR that added the T7 promoter, ribosome binding site, and a His6-tag. The PCR product was then used as a template for in vitro transcription/translation. The resulting His6-tagged recombinant protein was then purified by nickel affinity chromatography. The functionality of the purified protein was verified using protein microarray analysis.
T-dependent immunity in aged humans. II. Clinical and immunological evaluation after three months of administering a thymic extract. (1983)

We investigated the effect of Thymostimulin (TP-1) (a bovine thymic extract) on some clinical and immunological parameters in hospitalized aged humans. Forty aged patients were randomized into two groups, one received no therapy and the other was treated with TP-1 for 3 mth. The Ig and complement levels, sheep rosette-forming cells, absolute lymphocyte numbers and sedimentation rate were measured on days 0, 90 and 180. Moreover, the incidence of infections was determined. The baseline immunological data of the patients studied were within the normal range. These data remained unchanged after TP-1 treatment. In the TP-1 treated group we observed a significant reduction of infections (P=0.023) in comparison to the control group. A significant reduction of the sedimentation rate was also observed in the treated group.
Study of tissue‐type plasminogen activator binding sites on fibrin using distinct fragments of fibrinogen (1994)

It is well established that tissue-type plasminogen activator (t-PA) binds to the D region of fibrin(ogen) and that two distinct CNBr fragments of fibrinogen (FCB), FCB-2 and FCB-5, comprising parts of this region, stimulate plasminogen activation by t-PA. In the present work, ligand-binding studies were performed to characterize the interactions between t-PA and the corresponding fibrin regions using a well defined model of a fibrin surface and both FCB-2 and FCB-5 in liquid and solid phase. Binding isotherms showed a characteristic Langmuir adsorption saturation profile. The dissociation constants determined for the binding of t-PA to immobilized FCB-2 (Kd = 0.70 +/- 0.10 nM) and FCB-5 (Kd = 0.47 +/- 0.08 nM) were of the same order of magnitude as the Kd for fibrin binding (Kd = 1 +/- 0.2 nM). The specificity of the binding was demonstrated by the ability of soluble FCB-2 and FCB-5 to inhibit t-PA binding to solid-phase fibrin (Ki = 3.3 microM and 6.4 microM, respectively). The binding of t-PA to fibrin and to immobilized FCB-2 was partially inhibited by the lysine analogue 6-aminohexanoic acid (Ki = 123 +/- 47 microM and 364 microM, respectively) but was not modified by carboxypeptidase B, thus indicating involvement of internal lysine residues. Removal of lysine residues by treatment with, successively, plasmin and carboxypeptidase B, produced only a partial inhibition of t-PA binding, thus confirming the existence of both a lysine-dependent and a lysine-independent mechanism of binding of t-PA to both fibrin and FCB-2. In contrast, the binding of t-PA to FCB-5 was not significantly affected by 6-aminohexanoic acid. Altogether, these data indicate that the mechanism of binding of t-PA to fibrin involves mainly a lysine-independent interaction with the D region which is contributed by sequences present in FCB-5 and FCB-2; contribution to binding by a lysine-dependent interaction was detected only in FCB-2 and is probably of minor relevance as suggested by the limited effect of 6-aminohexanoic acid.
Safety and feasibility of autologous umbilical cord blood transfusion in 2 toddlers with cerebral palsy and the role of low dose granulocyte-colony stimulating factor injections (2011)

In this first report, autologous UCB based intervention in tandem with low dose sc G-CSF administration seems to be feasible and safe with encouraging functional outcome improvements in children with CP.
A planar piezoelectric drive with a stepping and a resonant operation mode (2003)

status: Published