gebhart/patrepeval huggingface dataset:
Neoplasias Mamárias em Gatas Domésticas: Possível Influência da Dieta na Etiologia (2013)

Os tumores mamários, na espécie felina, possuem informações limitadas a respeito de sua etiologia. Embora a atividade hormonal corresponda a uma das prováveis causas, sabe-se que a obesidade e uma dieta rica em gordura têm sido associadas com aumento do risco das neoplasias da glândula mamária. O presente trabalho objetivou analisar uma possível relação entre o tipo de dieta e a ocorrência de tumor mamário em felinos domésticos. Foi realizado um estudo retrospectivo com vinte e quatro gatas portadoras de neoplasias mamárias, obtendo-se dados relacionados ao tipo de alimentação e diagnóstico histopatológico da neoplasia, além de informações sobre raça e idade. Todos os animais foram acometidos por tumores mamários malignos, com maior concentração da patologia em fêmeas com dez anos de idade e da raça siamesa. Verificou-se que dezesseis (66,7%) gatas com neoplasias eram alimentadas com dieta mista (comida caseira e ração industrializada), enquanto cinco (20,8%) dos animais recebiam apenas ração industrializada e apenas três (12,5%) ingeriam dieta caseira. Nesse sentido, provavelmente uma dieta desequilibrada, com altos níveis calóricos, poderia ter predisposto a uma ocorrência de tumores de mama nas gatas analisadas. Outros estudos devem ser realizados a cerca da alimentação e neoplasias mamárias, possibilitando a adoção futura de estratégias para prevenir a incidência de tal patologia em fêmeas da espécie felina.
Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR) (1996)

Expression of the CFTR protein is thought to be physiologically important only in exocrine epithelial cells. However, chronic respiratory inflammation and infection remain unexplained phenomena in disease pathogenesis. Non-transformed, antigen-responsive CD4+ T cells cloned from healthy controls and CF patients homozygous or heterozygous for the delta F508 mutation transcribed CFTR mRNA and expressed immunoreactive cytoplasmic CFTR protein. T cell clones (TCC) from controls and CF patients displayed equivalent Ca(2+)-mediated Cl- current; however, TCC from patients with CF but not controls displayed defective cAMP-mediated Cl-current. Although CF-derived TCC preserved mitogen and antigen proliferative responses and specificity to tetanus toxoid epitopes, they selectively secreted approximately 45% less IL-10 compared with control TCC after activation with concanavalin A (Con A) (624 +/- 101 versus 1564 +/- 401 pg/ml per 10(6) cells, respectively; P = 0.04) or anti-CD3/phorbol ester (5148 +/- 1634 versus 11788 +/- 2390 pg/ml; P = 0.05). This difference was independent of atopy. Secretion of interferon-gamma, IL-2, and IL-4 was comparable in CF and control TCC after both forms of activation, while IL-5 was reduced in CF TCC following anti-CD3/phorbol myristate acetate (PMA) but not after Con A. We conclude that expression of mutant CFTR in human TCC is accompanied by ion channel dysfunction characteristic of the CF phenotype, and is accompanied by a reduction in IL-10 secretion after polyclonal activation. It is possible that disruption of IL-10-mediated anti-inflammatory homeostasis may contribute to early onset sustained inflammation in CF airways.
Alexander Sand, 1901-1945 (1948)

Abstract Alexander Sand was of Russian-Jewish extraction and born in Warsaw on 28 December 1901. His father belonged to the Menshevik party and the family came to England when Alec was six years old. He was educated at an L.C.C. school in Hampstead from 1909-1912, and then at Owen’s School, Islington, where he was from 1913-1920. While there he took no science but rose to the sixth form on the arts side. One of his masters recalls that he had a neat and orderly mind and was extraordinarily bright, ‘as sharp as a needle’, an expression which aptly fits him in his maturer years. A contemporary of his writes: ‘He was a person of considerable physical strength and fine physique, a good gymnast, though not an outstanding athlete. He was an exceptionally good pianist, and although he ultimately became a scientist he had literary and cultural standards far above those of the ordinary schoolboy, and artistic qualities which would have carried him far had he chosen a different walk in life. As an example of his versatility one might cite his playing the parts of Hippolytus and Falstaff with equal distinction. The character which remains most in my mind, however, is the polished wit and trenchant humour with which he met, observed and dealt with all the things he encountered. He was tolerant, yet intolerant of pettiness, and he appeared to despise any but clear thinking and honest purpose. He did not make friends easily, because others were apt to think him too censorious of mediocrity, but he was essentially a friendly person, and to those who ultimately knew him well, a source of inspiration, entertainment and wisdom.’
Simulating migrated and inverted seismic data by filtering a geologic model (2008)

Abstract The simulation of migrated and inverted data is hampered by the high computational cost of generating 3D synthetic data, followed by processes of migration and inversion. For example, simulating the migrated seismic signature of subtle stratigraphic traps demands the expensive exercise of 3D forward modeling, followed by 3D migration of the synthetic seismograms. This computational cost can be overcome using a strategy for simulating migrated and inverted data by filtering a geologic model with 3D spatial-resolution and angle filters, respectively. A key property of the approach is this: The geologic model that describes a target zone is decoupled from the macrovelocity model used to compute the filters. The process enables a target-orientedapproach, by which a geologically detailed earth model describing a reservoir is adjusted without having to recalculate the filters. Because a spatial-resolution filter combines the results of the modeling and migration operators, the simulated images can be compared directly to a real migration image. We decompose the spatial-resolution filter into two parts and show that applying one of those parts produces output directly comparable to 1D inverted real data. Two-dimensional synthetic examples that include seismic uncertainties demonstrate the usefulness of the approach. Results from a real data example show that horizontal smearing, which is not simulated by the 1D convolution model result, is essential to understand the seismic expression of the deformation related to sulfate dissolution and karst collapse.
Large area multi-stacked lithium-ion batteries for flexible and rollable applications (2014)

Large area multi-stacked lithium-ion battery modules are developed for flexible and rollable applications by employing conductive textiles.
Duty of Confidentiality in Korea (2009)

The duty of confidentiality is fundamental for the relationship between an attorney and the client. How and when the duty of confidentiality should be enforced upon an attorney has been debated in Korea, after a former in-house counsel of Samsung Group publicly disclosed that the chairman of Samsung allegedly engaged in illegal conduct. Relevant rules from the Korean Bar Association Code of Ethics and Conduct are not specific enough to allow one to assess the act of the former in-house counsel. This note analyzes the issue first under the Korean rules, and then under the relevant U.S. rules. While acknowledging the fact that direct adoption of a foreign set of rules would not be an effective way to deal with the domestic legal system, it would still be a useful exercise to compare the U.S. rules of professional conduct to the Korean counterpart in order to get a sense of what an appropriate standard should be for the duty of confidentiality for attorneys with an organization as a client.
Suspension polymerization of vinyl chloride at low temperature with the use of monomer‐soluble redox initiators (1961)

Abstract Suspension polymerization of vinyl chloride was carried out at temperatures of ‐30° to +30°C. with the use of a monomer‐soluble oxidation‐reduction initiator system. A typical initiator system was composed of lauroyl peroxide and ferrous n ‐caproate. The effects of temperature, molar ratio of peroxide to reducing agent, and total concentration of initiator upon the rate and degree of polymerization were observed. The activation energy of the overall rate of polymerization was 6.5 kcal./mole. Experimental evidence which may serve to elucidate the mechanism of the redox reaction in the nonemulsified system is discussed.
Identification of Rotavirus VP6 Residues Located at the Interface with VP2 That Are Essential for Capsid Assembly and Transcriptase Activity (2002)

Rotavirus has a complex triple-layered icosahedral capsid. The external layer consists of VP7 and VP4, the intermediate layer consists of VP6 trimers, and the internal layer consists of VP2. Double-layered particles (DLP) derived from the virus by solubilization of VP4 and VP7 are transcriptionally competent and extrude capped mRNA from their vertices. Analysis of the pseudoatomic model of the VP6 layer, obtained by placing the atomic structure of VP6 into electron microscopy reconstructions of the DLP, has identified the regions of the protein involved in interactions with the internal layer. To study the role of VP6 both in the assembly of DLP and in transcription, 13 site-specific substitution mutations of VP6, targeting the contacts between the two inner layers, were constructed and expressed in the baculovirus system. The effects of these mutations on VP6 expression, trimerization, and formation of macromolecular assemblies were investigated. Using either in vitro reconstituted DLP derived from purified viral cores and recombinant VP6 or in vivo self-assembled virus-like particles resulting from the coexpression of VP2 and VP6 in the baculovirus-Sf9 system (VLP2/6), we have identified the amino acids essential for recovery of transcription or assembly. All VP6 mutants formed stable trimers which, like wild-type VP6, assembled into tubular structures. The ability of VP6 to interact with VP2 was examined by several assays, including electron microscopy, coimmunoprecipitation, purification of VLP2/6, and monitoring of the transcriptase activity of reconstituted DLP. Of the 13 VP6 mutants examined, 3 were unable to assemble with VP2 and 3 others partially assembled. These mutants either did not rescue the transcriptase activity of core particles or did so only marginally. Four mutants as well as the wild-type VP6 assembled and transcribed very well. Three mutants assembled well on cores but, surprisingly, did not rescue the transcriptase activity of reconstituted DLP. Our results indicate that hydrophobic interactions between VP6 and VP2 residues are responsible for the stability of the DLP. They also show that subtle electrostatic interactions between VP6 and the underlying transcriptase machinery can be essential for mRNA synthesis.
Structural basis for the enantiospecificities of <i>R</i>‐ and <i>S‐</i>specific phenoxypropionate/α‐ketoglutarate dioxygenases (2006)

(R)- and (S)-dichlorprop/alpha-ketoglutarate dioxygenases (RdpA and SdpA) catalyze the oxidative cleavage of 2-(2,4-dichlorophenoxy)propanoic acid (dichlorprop) and 2-(4-chloro-2-methyl-phenoxy)propanoic acid (mecoprop) to form pyruvate plus the corresponding phenol concurrent with the conversion of alpha-ketoglutarate (alphaKG) to succinate plus CO2. RdpA and SdpA are strictly enantiospecific, converting only the (R) or the (S) enantiomer, respectively. Homology models were generated for both enzymes on the basis of the structure of the related enzyme TauD (PDB code 1OS7). Docking was used to predict the orientation of the appropriate mecoprop enantiomer in each protein, and the predictions were tested by characterizing the activities of site-directed variants of the enzymes. Mutant proteins that changed at residues predicted to interact with (R)- or (S)-mecoprop exhibited significantly reduced activity, often accompanied by increased Km values, consistent with roles for these residues in substrate binding. Four of the designed SdpA variants were (slightly) active with (R)-mecoprop. The results of the kinetic investigations are consistent with the identification of key interactions in the structural models and demonstrate that enantiospecificity is coordinated by the interactions of a number of residues in RdpA and SdpA. Most significantly, residues Phe171 in RdpA and Glu69 in SdpA apparently act by hindering the binding of the wrong enantiomer more than the correct one, as judged by the observed decreases in Km when these side chains are replaced by Ala.
Human Inter-α-Trypsin Inhibitor: Localization of the Kunitz-Type Domains in the N-terminal Part of the Molecule and their Release by a Trypsin-Like Proteinase (1985)

The N-terminal amino-acid sequence of human ITI has been found to be identical with that of the acid-stable human 30-kDa inhibitors (HI-30) from urine, serum, and those released from inter-alpha-trypsin inhibitor by trypsin or chymotrypsin. Serum HI-30 and HI-30 released by trypsin differ from the urinary inhibitor by an additional C-terminal arginine residue. Compared to these two inhibitors the inhibitor released by chymotryptic proteolysis is elongated C-terminally by an additional phenylalanine residue. These results strongly favour HI-30 as the N-terminus of the inter-alpha-trypsin inhibitor and its release from this inhibitor in vivo by cleavage of the Arg123-Phe124 peptide bond by trypsin-like proteinases.
The Precorneal Tear Film (1970)

Using artificial tear solutions with varying constituents in physiologic concentrations, surface chemical properties of the constituents have been studied. Both mucus (glycoprotein) and simple proteins are capable of lowering the surface tension of tears. Mucus has a great affinity for an oilwater interface. Conjunctival mucus spread by the action of the lids and adsorbed at the corneal surface is thought to be the principal factor in spreading the precorneal tear film. A hypothesis to explain the effect is presented.
Functional Production and Characterization of a Fibrin-Specific Single-Chain Antibody Fragment from<i>Bacillus subtilis</i>: Effects of Molecular Chaperones and a Wall-Bound Protease on Antibody Fragment Production (2002)

To develop an ideal blood clot imaging and targeting agent, a single-chain antibody (SCA) fragment based on a fibrin-specific monoclonal antibody, MH-1, was constructed and produced via secretion from Bacillus subtilis. Through a systematic study involving a series of B. subtilis strains, insufficient intracellular and extracytoplasmic molecular chaperones and high sensitivity to wall-bound protease (WprA) were believed to be the major factors that lead to poor production of MH-1 SCA. Intracellular and extracytoplasmic molecular chaperones apparently act in a sequential manner. The combination of enhanced coproduction of both molecular chaperones and wprA inactivation leads to the development of an engineered B. subtilis strain, WB800HM[pEPP]. This strain allows secretory production of MH-1 SCA at a level of 10 to 15 mg/liter. In contrast, with WB700N (a seven-extracellular-protease-deficient strain) as the host, no MH-1 SCA could be detected in both secreted and cellular fractions. Secreted MH-1 SCA from WB800HM[pMH1, pEPP] could be affinity purified using a protein L matrix. It retains comparable affinity and specificity as the parental MH-1 monoclonal antibody. This expression system can potentially be applied to produce other single-chain antibody fragments, especially those with folding and protease sensitivity problems.
Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin (2013)

Pathological cardiac hypertrophy is a major risk factor for heart failure. In this study, we identified interferon regulatory factor 9 (IRF9), a member of the IRF family, as a previously unidentified negative regulator of cardiac hypertrophy. The level of IRF9 expression was remarkably elevated in the hearts from animals with aortic banding-induced cardiac hypertrophy. IRF9-deficient mice exhibited pronounced cardiac hypertrophy after pressure overload, as demonstrated by increased cardiomyocyte size, extensive fibrosis, reduced cardiac function, and enhanced expression of hypertrophy markers, whereas transgenic mice with cardiac-specific overexpression of murine IRF9 exhibited a significant reduction in the hypertrophic response. Mechanistically, IRF9 competes with p300 for binding to the transcription activation domain of myocardin, a coactivator of serum response factor (SRF). This interaction markedly suppresses the transcriptional activity of myocardin because IRF9 overexpression strongly inhibits the ability of myocardin to activate CArG box-dependent reporters. These results provide compelling evidence that IRF9 inhibits the development of cardiac hypertrophy by suppressing the transcriptional activity of myocardin in the heart.
Simple push-pull glass valves (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple push-pull glass valvesSteven G. Platt , Wallace Erwin , and Cees W. DeGroot Cite this: J. Chem. Educ. 1978, 55, 9, 609Publication Date (Print):September 1, 1978Publication History Received3 August 2009Published online1 September 1978Published inissue 1 September 1978https://doi.org/10.1021/ed055p609RIGHTS & PERMISSIONSArticle Views19Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (409 KB) Get e-Alerts Get e-Alerts
One culture two systems: a cultural approach to Inter-Chinese politics (1998)

Extract: In this article we seek to step beyond the problematic notion of "One China", politically speaking, by emphasizing "One Culture" constituted by different systems or a diversity of subcultures. In so doing, what is essentially an either/or choice transforms to a one-many realization.
OPTICAL MONITOR OF GLUCOSE (1979)

Methods have been described to noninvasively monitor the glucose of the aqueous humor, a fluid with glucose in constant equilibrium with the bloodstream. A feasibility study has been performed showing that the optical rotation of the aqueous humor reflects aqueous humor glucose concentration in the range of hypo- and moderately hyperglycemic conditions. Preliminary data show that specificity for glucose may be enhanced by simultaneously measuring the optical rotation at 984 nm and 775 nm.
REVIEWS (1923)

REVIEWS Get access The Psychic health of Jesus, by WALTER E. BUNDY ( The Macmillan Co., New York, 1922.) J. F. B-B J. F. B-B Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume os-XXIV, Issue 96, July 1923, Page 466, https://doi.org/10.1093/jts/os-XXIV.96.466 Published: 01 July 1923
Digital simulation of tubular electrode response in stationary and flowing solution (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDigital simulation of tubular electrode response in stationary and flowing solutionJames B. Flanagan and Lynn MarcouxCite this: J. Phys. Chem. 1974, 78, 7, 718–723Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://doi.org/10.1021/j100600a015Request reuse permissionsArticle Views81Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (660 KB) Get e-Alerts
Strategy for enhanced transgenic strain development for embryonic conditional lethality in <i>Anastrepha suspensa</i> (2012)

Here the first reproductive sterility system for the tephritid fruit fly pest, Anastrepha suspensa, is presented, based on lethality primarily limited to embryos heterozygous for a conditional lethal transgene combination. This tetracycline (Tet)-suppressible system uses a driver construct having the promoter from the newly isolated embryo-specific A. suspensa serendipity α gene linked to the Tet-transactivator. This was used to drive expression of a phosphomutated variant of the pro-apoptotic cell death gene, hid, from A. ludens, that was isolated, based on its identity to A. suspensa hid. The Alhid(Ala2) variant was shown to have the highest cell death activity in an in vitro A. suspensa cell death assay compared to the orthologous genes Ashid, Dmhid, and the variant Dmhid(Ala5). These cell death assays also allowed a determination of the most-efficient driver-effector cassette combinations for use in A. suspensa transformants, resulting in two hybrid strains exhibiting 100% lethality. One strain was 96% lethal in embryos in the absence of tetracycline, with none surviving past the first larval instar, which is critical for pests that are most damaging in late-larval stages. We demonstrate that the isolation and in vitro validation of species-specific promoters and lethal effector genes can greatly improve the efficiency of creating high-performance conditional lethality strains that may be extended to other insect pest species.
Updated Glucosinolate Profile of <i>Dithyrea wislizenii</i> (2009)

Fruit extracts of Dithyrea wislizenii were analyzed for desulfoglucosinolates and intact glucosinolates using HPLC-APCI-MS and HPLC-ESI-MS, respectively. 2-Propenylglucosinolate (sinigrin) was shown to be present in the extracts. 6-Methylsulfanylhexyl- (glucolesquerellin 9), 6-methylsulfinylhexyl- (glucohesperin 10), 7-methylsulfanylheptyl- (11), and 5-methylsulfanylpentylglucosinolate (glucoberteroin 12) were isolated from the extracts and characterized by NMR and MS data. 7-Methoxyglucobrassicin was not detected in D. wislizenii extracts.
Probabilistic latent tensor factorization framework for audio modeling (2011)

This paper introduces probabilistic latent tensor factorization (PLTF) as a general framework for hierarchical modeling of audio. This framework combines practical aspects of graphical modeling of machine learning with tensor factorization models. Once a model is constructed in the PLTF framework, the estimation algorithm is immediately available. We illustrate our approach using several popular models such as NMF or NMF2D and provide extensions with simulation results on real data for key audio processing tasks such as restoration and source separation.