gebhart/patrepeval huggingface dataset:
Tumor Necrosis Factor-α Upregulates the Prostaglandin E <sub>2</sub> EP1 Receptor Subtype and the Cyclooxygenase-2 Isoform in Cultured Amnion WISH Cells (1998)

Recent studies have demonstrated a strong correlation between infection and preterm labor. Preterm delivery is also associated with high levels of cytokines and prostaglandins in amniotic fluid. The purpose of this study was to investigate the effect of tumor necrosis factor-alpha (TNF-alpha) on the levels of cyclooxygenase, prostaglandin E2 production (PGE2), and expression of the PGE2 receptor subtype EP1 in amnion WISH cell culture. Amnion WISH cell cultures were incubated in increasing concentrations of TNF-alpha (0-50 ng/ml). Changes in cyclooxygenase and EP1 receptor proteins were evaluated by Western blot analysis. Changes in EP1 mRNA were evaluated by Northern blot, and culture fluid concentrations of PGE2 were estimated by enzyme immunoassay (EIA). EP1 protein (p<0.01), EP1 mRNA (p<0.05), cyclooxygenase-2 (COX-2) protein (p<0.001), and PGE2 concentrations (p<0.01) all increased with increasing concentrations of TNF-alpha. Changes in COX-1 protein were not observed following TNF-alpha-incubation. The results suggest that TNF-alpha may play a role in infection-induced preterm labor by its pleiotropic ability to simultaneously stimulate COX-2 activity, PGE2 concentrations, and PGE2 EP1 receptor levels in human amnion.
Abscisic acid analogs with a geometrically rigid conjugated acid side-chain. (1986)

In recent years, studies on the more subtle biological actions of abscisic acid (ABA, 1)1} have revealed many new facets of this plantgrowth hormone. Particularly significant is the finding that the endogenous ABA concentration is positively correlated with plant stress,2'3) suggesting that ABAplays a unique role as a stress hormone. It was anticipated
Defense Technical Information Center Free Text Experiment - Technical Report File. (1981)

DTIC has conducted an experiment that utilizes the free text inversion technique to retrieve records from the Technical Reports data base. It was felt that free text inversion as a form of retrieval would be beneficial in supporting DTIC's revitalized role in the transfer of technical information. The intent of this project was to determine if the free text inversion technique could be implemented on the DROLS on-line system without severely impacting the on-line system's storage capacity and to determine whether the added capability could improve upon or replace the present practice of using open-ended/identifier indexing terminology. Based on the results of the experiment, it was determined that searching of DTIC's Technical Reports data base is a viable retrieval technique that will provide searchers with an additional enhancement that can be used to augment DTIC's present retrieval methods. However, evidence that will support the use of free text in lieu of the use of identifiers and open-ended terminology remains inconclusive. Additional data collected in a 'live environment' will have to be analyzed before a conclusion can be made concerning the use of open-ended terminology.
NOTES ON THE LARVA OF THE PITCHER - PLANT MOSQUITO (1905)

Since the discovery of Wyeomyia Smithii in the leaves of Pitcher plants in New Jersey, by Dr.J.B. Smith, it has been reported from Massachusetts and Florida. On June 16tg of the present year, the writer found a larva of the second stage in a Pitcher-plant in a greenhouse in the Botanical Gardens, Washington, D.C. July 8th, three more specimens were taken there The plants had been brought from South Carolina, and had been in the greenhouse for several Years.
Longitudinal change of small-vessel disease-related brain abnormalities (2015)

Knowledge about the longitudinal change of cerebral small-vessel disease–related magnetic resonance imaging abnormalities increases our pathophysiologic understanding of cerebral microangiopathy. The change of specific lesion types may also serve as secondary surrogate endpoint in clinical trials. A surrogate endpoint needs to progress fast enough to allow monitoring of treatment effects within a reasonable time period, and change of the brain abnormality needs to be correlated with clinical change. Confluent white matter lesions show fast progression and correlations with cognitive decline. Thus, the change of confluent white matter lesions may be used as a surrogate marker in proof-of-concept trials with small patient numbers needed to show treatment effects on lesion progression. Nonetheless if the expected change in cognitive performance resulting from treatment effects on lesion progression is used as outcome, the sample size needed to show small to moderate treatment effects becomes very large. Lacunes may also fulfill the prerequisites of a surrogate marker, but in the general population the incidence of lacunes over short observational periods is small. For other small-vessel disease–related brain abnormalities including microbleeds and microstructural changes in normal-appearing white matter longitudinal change and correlations with clinical decline is not yet fully determined.
Optimization of ATM filling-in with cash (2014)

A series of quaternary ammonium compounds that are esters of betaine and fatty alcohols with hydrocarbon chain lengths of 10 to 18 carbon atoms were tested with respect to antimicrobial activities and rates of hydrolysis. When the tetradecyl derivative was tested against some selected microorganisms, the killing effect was comparable to that of the stable quaternary ammonium compound cetyltrimethylammonium bromide. At higher pH values, both the antimicrobial effect and the rate of hydrolysis of the esters increased. However, whereas at pH 6 greater than 99.99% killing of Salmonella typhimurium was achieved with 5 micrograms/ml in 3 min, the rate of hydrolysis was less than 20% in 18 h. At pH 7, a similar killing effect was achieved in 2 min and 50% hydrolysis occurred in ca. 5 h. Thus, it is possible to exploit the rapid microbicidal effect of the compounds before they hydrolyze. The rate of hydrolysis was reduced by the presence of salt. The bactericidal effect of the betaine esters increased with the length of the hydrocarbon chain of the fatty alcohol moiety up to 18 carbon atoms. Since the hydrolysis products are normal human metabolites, the hydrolysis property may extend the use of these quaternary ammonium compounds as disinfectants and antiseptics for food and body surfaces.
Multilevel fluidic flow control in a rotationally-driven polyester film microdevice created using laser print, cut and laminate (2015)

This paper presents a simple and cost-effective polyester toner microchip fabricated with laser print and cut lithography (PCL) to use with a battery-powered centrifugal platform for fluid handling. The combination of the PCL microfluidic disc and centrifugal platform: (1) allows parallel aliquoting of two different reagents of four different volumes ranging from nL to μL with an accuracy comparable to a piston-driven air pipette; (2) incorporates a reciprocating mixing unit driven by a surface-tension pump for further dilution of reagents, and (3) is amenable to larger scale integration of assay multiplexing (including all valves and mixers) without substantially increasing fabrication cost and time. For a proof of principle, a 10 min colorimetric assay for the quantitation of the protein level in the human blood plasma samples is demonstrated on chip with a limit of detection of ∼5 mg mL(-1) and coefficient of variance of ∼7%.
[Detection of epidermal growth factor-like factors in various skin tumors]. (1990)

EGF-like factors (EGF-F) in tissue extracts make use of the EGF receptor system (EGF-R) in order to transmit biological signals. EGF-F, which partly show transforming activities, can be detected with the help of an EGF receptor assay. We measured the EGF concentrations in extracts of 25 benign, 5 semi-malignant, and 13 malignant skin tumors, as well as in 5 biopsies of normal skin. The highest amounts of EGF-F were found in malignant melanoma (10 ng/mg) and in squamous cell carcinoma (7 ng/mg). The EGF-F concentrations in benign and semi-malignant tumors, in contrast, were similar to those found in normal skin (up to 4 ng/mg). Isoelectric focusing (IEF) revealed that the activity of EGF-F malignant tumors consists of various components.
Denial of service via algorithmic complexity attacks (2003)

We present a new class of low-bandwidth denial of service attacks that exploit algorithmic deficiencies in many common applications&apos; data structures. Frequently used data structures have &quot;average-case&quot; expected running time that&apos;s far more efficient than the worst case. For example, both binary trees and hash tables can degenerate to linked lists with carefully chosen input. We show how an attacker can effectively compute such input, and we demonstrate attacks against the hash table implementations in two versions of Perl, the Squid web proxy, and the Bro intrusion detection system. Using bandwidth less than a typical dialup modem, we can bring a dedicated Bro server to its knees; after six minutes of carefully chosen packets, our Bro server was dropping as much as 71% of its traffic and consuming all of its CPU. We show how modern universal hashing techniques can yield performance comparable to commonplace hash functions while being provably secure against these attacks.
Vascular cell-derived heparan sulfate shows coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular smooth muscle cells. (1993)

Basic fibroblast growth factor (bFGF) has been previously shown to be mitogenic for vascular smooth muscle cells (VSMCs) in vivo, but only after vascular injury. We show in the present study that the regulation of bFGF-stimulated VSMC proliferation, by vascular cell-secreted heparin-like compounds, correlates with inhibition of bFGF binding to cell-associated heparin sulfate proteoglycans. The stimulation of cultured VSMC proliferation by bFGF was markedly reduced when these cells were cocultured with confluent endothelial cells or confluent VSMCs (100.8 +/- 8.4% and 55.6 +/- 2.3% inhibition, respectively) or with conditioned media from these two cell types. Balb/c3T3 fibroblasts had no statistically significant effect on bFGF-stimulated VSMC proliferation. Vascular cell-conditioned media also inhibited bFGF binding to heparan sulfate proteoglycans on VSMCs, and the inhibition of binding correlated linearly with the inhibition of proliferation after a critical amount of binding was inhibited (44%) (r = .952, P < .0001). Heparinase or heparitinase treatment of conditioned media removed the bFGF-inhibitory effects, presumably by degrading heparin-like compounds. Indeed, heparin itself mimicked the inhibitory effects of conditioned media on bFGF-mediated proliferation and binding to heparin sulfate proteoglycans. These results suggest a bFGF regulatory role for vascular cell-produced heparin-like compounds, linking the mitogenic effects with binding to heparan sulfate proteoglycans for this heparin-binding growth factor.
Recent Advances and Future Trends for Automotive Functional Safety Design Methodologies (2020)

Guaranteeing safety is always a prerequisite in the process of realizing various automotive applications. However, the automotive functional safety design has been challenged by multiple factors, such as the complexity of the new generation automotive electrical and electronic (E/E) architecture, the continuous release and update of automotive functional safety standard International Standardization Organization (ISO) 26262, the release of new AUTOSAR adaptive platform standard, and the increase in different types of costs. In this article, we summarize the recent advances of automotive functional safety design methodologies through analysis, design, optimization, and runtime phases, respectively: 1) functional safety analysis; 2) functional safety guarantee; 3) safety-aware cost optimization; and 4) safety-critical multifunctional scheduling. Then, we provide the future trends in functional safety design methodologies that will be directly oriented to autonomous vehicles and adapt to the next generation functional safety standard ISO 21448.
Hand Hygiene Compliance Rates in the United States—A One-Year Multicenter Collaboration Using Product/Volume Usage Measurement and Feedback (2009)

Hand hygiene (HH) is the single most important factor in the prevention of health care-acquired infections. The 3 most frequently reported methods of measuring HH compliance are: (1) direct observation, (2) self-reporting by health care workers (HCWs), and (3) indirect calculation based on HH product usage. This article presents the results of a 12-month multicenter collaboration assessing HH compliance rates at US health care facilities by measuring product usage and providing feedback about HH compliance. Our results show that HH compliance at baseline was 26% for intensive care units (ICUs) and 36% for non-ICUs. After 12 months of measuring product usage and providing feedback, compliance increased to 37% for ICUs and 51% for non-ICUs. (ICU, P = .0119; non-ICU, P < .001). HH compliance in the United States can increase when monitoring is combined with feedback. However, HH still occurs at or below 50% compli- ance for both ICUs and non-ICUs.
A novel degree distribution algorithm of LT codes (2008)

This paper proposed the optimal degree distribution algorithm of LT codes and analyzed its drawbacks in realization. On the basis of the optimal degree distribution algorithm, a novel suboptimal degree distribution algorithm was put forward. Through Test, with respect to the average decoding efficiency, the best decoding efficiency and the variance of decoding efficiencies, the LT codes with suboptimal degree distribution algorithm performs better than that with robust soliton degree distribution algorithm. The conclusion of research is practically valuable in improving efficiencies of data distribution applications.
Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation (2015)

Our results showed that autoclaving the pretreated feedstocks offered advantages over the addition of antibiotics for hydrolysate production. The autoclaving method produced a more consistent quality of hydrolysate, and also showed negligible effects on microbial performance. Although the levels of some of the lignocellulose degradation inhibitors were elevated by autoclaving the feedstocks prior to enzymatic hydrolysis, no significant effects on cell growth, sugar utilization, or ethanol production were seen during bacterial or yeast fermentations in hydrolysates produced using the two different methods.
The Local Side Effects of Transdermally Absorbed Nicotine (1992)

Percutaneous nicotine administration induces predominant sudorific and rubiform responses in the skin which may be accompanied by subtle piloerection, hyperalgesia and pruritus (although these signs are not overtly manifest). These dermal responses are complex and mechanisms have been proposed for the direct nicotine-stimulation of sweat glands, piloerection and vasoconstriction. These reactions are accompanied by secondary activation and release of vasodilator peptides which produce a predominating vasodilator tone following topical administration, this response masking the direct axon reflex-mediated vasoconstriction.
Synthesis of 2‐monoglycerides by alcoholysis of palm oil and tuna oil using immobilized lipases (2003)

Abstract Commercial immobilized lipases were used for the synthesis of 2‐monoglycerides (2‐MG) by alcoholysis of palm and tuna oils with ethanol in organic solvents. Several parameters were studied, i.e. , the type of immobilized lipases, water activity, type of solvents and temperatures. The optimum conditions for alcoholysis of tuna oil were at a water activity of 0.43 and a temperature of 60 °C in methyl‐ tert ‐butyl ether for ∼12 h. Although immobilized lipase preparations from Pseudomonas sp. and Candida antarctica fraction B are not 1, 3‐regiospecific enzymes, they were considered to be more suitable for the production of 2‐MG by the alcoholysis of tuna oil than the 1, 3‐regiospecific lipases (Lipozyme RM IM from Rhizomucor miehei and lipase D from Rhizopus delemar ). With Pseudomonas sp. lipase a yield of up to 81% 2‐MG containing 80% PUFA (poly‐unsaturated fatty acids) from tuna oil was achieved. The optimum conditions for alcoholysis of palm oil were similar as these of tuna oil alcoholysis. However, lipase D immobilized on Accurel EP100 was used as catalyst at 40 °C with shorter reaction times (<12 h). This lead to a yield of ∼60% 2‐MG containing 55.0‐55.7% oleic acid and 18.7‐21.0% linoleic acid.
Soft Decision FEC for 100G Transport Systems (2010)

A practical implementation of soft decision based FEC for 100G transport systems is discussed. The keys are a stronger coding gain using triple-concatenated FEC and a multi-lane distribution architecture to improve the error correction capability.
Power analysis and low-power scheduling techniques for embedded DSP software (1995)

Abstract: This paper describes the application of a measurement based power analysis technique for an embedded DSP processor. An instruction-level power model for the processor has been developed using this technique. Significant points of difference have been observed between this model and the ones developed earlier for some general-purpose commercial microprocessors. In particular, the effect of circuit state on the power cost of an instruction stream is more marked in the case of this DSP processor. In addition, the DSP processor has a special architectural feature that allows instructions to be packed into pairs. The energy reduction possible through the use of this feature is studied. The on-chip Booth multiplier on the processor is a major source of energy consumption for DSP programs. A micro-architectural power model for the multiplier is developed and analyzed for further energy minimization. A scheduling algorithm incorporating these new techniques is proposed to reduce the energy consumed by DSP software. Energy reductions varying from 11% to 56% have been observed for several example programs. These energy savings are real and have been verified through physical measurement.
Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil (2014)

Block of the hERG potassium channel and prolongation of the QT interval are predictors of drug-induced torsade de pointes. However, drugs that block the hERG potassium channel may also block other channels that mitigate torsade risk. We hypothesized that the electrocardiogram can differentiate the effects of multichannel drug block by separate analysis of early repolarization (global J-Tpeak) and late repolarization (global Tpeak-Tend). In this prospective randomized controlled clinical trial, 22 subjects received a pure hERG potassium channel blocker (dofetilide) and three drugs that block hERG and either calcium or late sodium currents (quinidine, ranolazine, and verapamil). The results show that hERG potassium channel block equally prolongs early and late repolarization, whereas additional inward current block (calcium or late sodium) preferentially shortens early repolarization. Characterization of multichannel drug effects on human cardiac repolarization is possible and may improve the utility of the electrocardiogram in the assessment of drug-related cardiac electrophysiology.
Design of a SIP-based real-time visitor communication and door control architecture using a home gateway (2006)

Typical video door phone systems that allow people inside the home to communicate with visitors at the door have notable shortcomings: the resident must be physically in the home and is not informed of any missed visits upon returning home. To overcome these limitations, we propose an architecture supporting user mobility, whereby the resident can monitor visitors at their front door using the communication-capable devices such as PCs, PDAs, and home servers with Internet connections, regardless of physical constraints. We implemented the proposed architecture based on the session initiation protocol and a home gateway system connected to a conventional intercom or a video door phone
Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial (2017)

Although non-alcoholic fatty liver disease (NAFLD) is the leading aetiology of liver disorders in the world, there is no proven treatment for NAFLD patients with normal or low BMI. The aim of this study was to evaluate the efficacy of synbiotics supplementation in NAFLD patients with normal or low BMI. In this randomised, double-blind, placebo-controlled, clinical trial, fifty patients with NAFLD were assigned to take either a synbiotic supplement or a placebo capsule for 28 weeks. Both groups were advised to follow a healthy lifestyle. At the end of the study, hepatic steatosis and fibrosis reduced in both groups; however, the mean reduction was significantly greater in the synbiotic group rather than in the placebo group (P<0·001). Furthermore, serum levels of fasting blood sugar, TAG and most of the inflammatory mediators reduced in the synbiotic group significantly compared with the placebo group (P<0·05). Our results provide evidence that synbiotic supplementation improves the main features of NAFLD in patients with normal and low BMI, at least partially through reduction in inflammatory indices. Further studies are needed to address the exact mechanism of action of these effects.
Adsorption of Doxorubicin on Poly(methyl methacrylate)–Chitosan–Heparin-Coated Activated Carbon Beads (2012)

Extracorporeal filter cartridges, filled with an activated carbon bead (ACB) adsorbent, have been used for removal of overdosed cancer drugs from the blood. Coatings on adsorbent matrices, poly(methyl methacrylate) (PMMA)/activated carbon bead and PMMA/chitosan/heparin/ACB composites, were tested to improve their biocompatibility and blood compatibility. PMMA coating on ACBs was accomplished in a straightforward manner using a PMMA solution in ethyl acetate. A one-step hybrid coating of ACBs with PMMA-anticoagulant heparin required the use of acetone and water co-solvents. Multilayer coatings with three components, PMMA, chitosan, and heparin, involved three steps: PMMA was first coated on ACBs; chitosan was then coated on the PMMA-coated surface; and finally, heparin was covalently attached to the chitosan coating. Surface morphologies were studied by scanning electron microscopy. X-ray photoelectron spectroscopy confirmed the -SO(3)(-) group. Adsorption, of a chemotherapy drug (doxorubicin) from both water and phosphate-buffered saline, by the coated ACBs was examined. The adsorption isotherm curves were fitted using the Freundlich model. The current adsorption system might find potential applications in the removal of high-dose regional chemotherapy drugs while maintaining high efficiency, biocompatibility, and blood compatibility.