gebhart/patrepeval huggingface dataset:
Cloud Application HA Using SDN to Ensure QoS (2015)

Users expect cloud applications to be highly available with minimum service disruption. Some of the cloud applications also have Quality of Service (QoS) requirements. The High Availability (HA) module needs to consider QoS requirements while placing or failing over the application, application's components and its replicas. In this paper we propose a new QoS module in the SDN controller. This module creates QoS queues with certain minimum bandwidth on Open Flow based switches on the route between components requiring certain minimum network bandwidth. Our approach is similar to 'Aggregation of RSVP for IPv4 and IPv6 Reservations' (RFC 3175). DiffServ based approaches reserve bandwidth for an entire class of flows and do not cater for requirements from individual applications. Our approach reserves bandwidth on a per-flow basis while overcoming the well-known scalability problem of IntServ. Also, the QoS queues are dynamically configured based on the current requirements of the applications. The QoS module is also responsible for ensuring QoS when topology and route changes. The HA module will interact with SDN controller (which includes our QoS module) to ensure QoS requirements of cloud applications. We also tried an intermediate approach where the QoS flows are directed to a DiffServ queue with a fixed rate (mentioned in RFC 3175) and the reservation of the queue is reconfigured only when the total reservation for the QoS flows exceed the initial reservation. We demonstrate the feasibility and performance aspect of our approach from experiments using Mininet.
Bioavailability of Carbohydrate Content in Natural and Transgenic Switchgrasses for the Extreme Thermophile Caldicellulosiruptor bescii (2017)

Improving access to the carbohydrate content of lignocellulose is key to reducing recalcitrance for microbial deconstruction and conversion to fuels and chemicals. <i>Caldicellulosiruptor bescii</i> completely solubilizes naked microcrystalline cellulose, yet this transformation is impeded within the context of the plant cell wall by a network of lignin and hemicellulose. Here, the bioavailability of carbohydrates to <i>C. bescii</i> at 70°C was examined for reduced lignin transgenic switchgrass lines COMT3(+) and MYB Trans, their corresponding parental lines (cultivar Alamo) COMT3(-) and MYB wild type (WT), and the natural variant cultivar Cave-in-Rock (CR). Transgenic modification improved carbohydrate solubilization by <i>C. bescii</i> to 15% (2.3-fold) for MYB and to 36% (1.5-fold) for COMT, comparable to the levels achieved for the natural variant, CR (36%). Carbohydrate solubilization was nearly doubled after two consecutive microbial fermentations compared to one microbial step, but it never exceeded 50% overall. Hydrothermal treatment (180°C) prior to microbial steps improved solubilization 3.7-fold for the most recalcitrant line (MYB WT) and increased carbohydrate recovery to nearly 50% for the least recalcitrant lines [COMT3(+) and CR]. Alternating microbial and hydrothermal steps (T→M→T→M) further increased bioavailability, achieving carbohydrate solubilization ranging from 50% for MYB WT to above 70% for COMT3(+) and CR. Incomplete carbohydrate solubilization suggests that cellulose in the highly lignified residue was inaccessible; indeed, residue from the T→M→T→M treatment was primarily glucan and inert materials (lignin and ash). While <i>C. bescii</i> could significantly solubilize the transgenic switchgrass lines and natural variant tested here, additional or alternative strategies (physical, chemical, enzymatic, and/or genetic) are needed to eliminate recalcitrance.<b>IMPORTANCE</b> Key to a microbial process for solubilization of plant biomass is the organism's access to the carbohydrate content of lignocellulose. Economically viable routes will characteristically minimize physical, chemical, and biological pretreatment such that microbial steps contribute to the greatest extent possible. Recently, transgenic versions of plants and trees have been developed with the intention of lowering the barrier to lignocellulose conversion, with particular focus on lignin content and composition. Here, the extremely thermophilic bacterium <i>Caldicellulosiruptor bescii</i> was used to solubilize natural and genetically modified switchgrass lines, with and without the aid of hydrothermal treatment. For lignocellulose conversion, it is clear that the microorganism, plant biomass substrate, and processing steps must all be considered simultaneously to achieve optimal results. Whether switchgrass lines engineered for low lignin or natural variants with desirable properties are used, conversion will depend on microbial access to crystalline cellulose in the plant cell wall.
A haploid and a diploid cell cycle coexist in an in vitro immortalized spermatogenic cell line (1995)

We have recently established a conditionally immortalized germ cell line [GC-2spd(ts)] that, at the permissive temperatures of 37 degrees C and 32 degrees C, is able to undergo meiosis in vitro and form round spermatids [Hofmann et al., (1994): Proc Natl Acad Sci USA 91:5533-5537]. In this report, we provide data that indicate that the GC-2spd(ts) cell line consists of two cell populations undergoing a haploid (n/2n) cell cycle and a diploid (2n/4n) cell cycle, respectively. The cells containing 2n DNA, when sorted by fluorescence-activated cell sorting, are able to reconstitute the full population of n/2n/4n DNA cells, indicating that they are able to commit to the reductive meiotic division and form haploid spermatids or to continue self-replication through a diploid cell cycle. This GC-2spd(ts) cell line provides a valuable tool to study the molecular mechanisms involved in the cellular decision between self-renewal by mitosis and commitment to meiosis.
Disordered Lithium‐Rich Oxyfluoride as a Stable Host for Enhanced Li<sup>+</sup> Intercalation Storage (2015)

A new intercalation compound Li2VO2F with disordered rock-salt structure enables up to ≈1.8 Li+ storage (420 mAh g−1) at ≈2.5 V with a lattice volume change of only ≈3%. A high capacity of 300 mAh g−1 at 1C rate is observed. At –10 °C, Li2VO2F can deliver a reversible capacity of 280 mAh g−1 at ≈2.4 V.
Size of Supramolecular SNARE Complex:  Membrane-Directed Self-Assembly (2005)

Full length v-SNARE protein in lipid vesicles when exposed to t-SNARE-reconstituted lipid membrane results in the self-assembly of a t-/v-SNARE complex in a ring pattern, forming pores, and establishing continuity between the opposing bilayers. It is known that smaller vesicles fuse more efficiently than larger ones, and hence the curvature of secretory vesicles may dictate the potency and efficacy of their fusion at the cell plasma membrane. The diameter of t- and v-SNARE vesicles may, therefore, reflect the size of the t-/v-SNARE complex formed. In the present study, this hypothesis was tested, and results from the study demonstrate that the size of the t-/v-SNARE complex is directly proportional to the vesicle diameter (R2 = 0.9725).
Pembrolizumab: a novel antiprogrammed death 1 (PD-1) monoclonal antibody for treatment of metastatic melanoma (2015)

Pembrolizumab is a novel anti-PD-1 monoclonal antibody that is an effective option for advanced melanoma previously treated with agents such as ipilimumab and BRAF inhibitors. Additional studies will provide the necessary data for determining its true place in therapy for advanced melanoma and exploring its efficacy in additional malignant indications.
Sound source tracking with directivity pattern estimation using a 64 ch microphone array (2005)

In human-robot communication, a robot should distinguish between voices uttered by a human and those played by a loudspeaker such as on a TV or a radio. This paper addresses detection of actual human voices by using a microphone array as an extension of auditory function of the robot to support environmental understanding by the robot. We introduce a 64 ch microphone array system in a room and propose a new method based on weighted delay-and-sum beamforming to estimate a directivity pattern of a sound source. The microphone array system localizes a sound source and estimates its directivity pattern. The directivity pattern estimation has two advantages as follows: One is that the system can detect whether the sound source is an actual human voice or not by comparing the estimated directivity pattern with prerecorded directivity patterns. The other is that the heading of the sound source is estimated by detecting the angle with the highest power in the directivity pattern. As a result, we proved the effectiveness of our microphone array through sound source tracking with orientation and detection of actual human voices based on directivity pattern estimation.
Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain (2003)

Intraperitoneal injection of kainic acid (KA) in C57BL/6J and 129T2SvEmsJ mice led to a transient induction of uncoupling protein-2 (Ucp2) mRNA expression in several brain regions, which included the CA1 subfield of the hippocampus, the dorsal endopiriform nucleus and the piriform cortex in both strains. In all those regions, levels of Ucp2 mRNA expression, as determined by in situ hybridization, peaked at 24 h and returned to basal levels within 72 h post-injection. The increase in mRNA expression was mainly observed in neurons, with microglial cells displaying only scattered expression of the gene. The neuronal induction of Ucp2 in response to KA was stronger in 129T2SvEmsJ mice than in C57BL/6J, which suggests a role for Ucp2 in excitotoxic challenges and neuroprotection.
CdTe films on (001) GaAs:Cr by molecular beam epitaxy (1984)

CdTe films grown by molecular beam epitaxy on a (001) GaAs with a 14% lattice mismatch were found to be a very good crystalline quality. The films were found by reflection high-energy electron diffraction analysis to be oriented (111) parallel to the surface of the (001) GaAs. Further, the [112̄] azimuth of CdTe and the [110] of GaAs were aligned. Photoluminescence studies suggest that the films are of high crystalline quality but peaks associated with impurities are observed in the spectra. The optimum growth temperature is about 250 °C.
A coupled sawtooth oscillator combining low jitter with high control linearity (2002)

A new type of relaxation oscillator is presented that combines excellent control linearity with low timing jitter. By using an alternative for the Schmitt trigger, the jitter caused by threshold level noise can be significantly reduced compared to a conventional relaxation oscillator, under equal conditions of control linearity. Circuits realized in a 0.8-/spl mu/m CMOS process show a typical measured distortion in the control characteristic of HD/sub 2/ = -67 dB and HD/sub 3/ = -90 dB (/spl Delta/f = 500 KHz), without using any feedback linearization techniques. The measured phase noise is -102 dBc/Hz at 10-kHz offset at f/sub osc/ = 1.5 MHz (65-ppm rms jitter) for a total supply current of 360 /spl mu/A.
Structure of FR900359, a cyclic depsipeptide from Ardisia crenata sims (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of FR900359, a cyclic depsipeptide from Ardisia crenata simsMamoru Fujioka, Shigetaka Koda, Yukiyoshi Morimoto, and Klaus BiemannCite this: J. Org. Chem. 1988, 53, 12, 2820–2825Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00247a030https://doi.org/10.1021/jo00247a030research-articleACS PublicationsRequest reuse permissionsArticle Views724Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study (2008)

Because the correlation between anti-MCV levels and parameters of disease activity was very low, we conclude that it is not useful to monitor disease activity with anti-MCV levels.
Robust low-delay audio coding using multiple descriptions (2005)

This paper proposes an encoding method for high-quality, low-delay audio communication that is robust to losses in packetized transmission. Robustness is provided by a multiple description vector quantization (MDVQ) technique that is designed to minimize the mean-squared error (MSE). The key to applying this technique effectively is the use of psycho-acoustically controlled preand post-filters that make the mean-squared quantization error perceptually relevant. Experiments show that the MDVQ-based encoder yields better results-in both MSE and subjective audio quality-than simple alternative coders with the same low delay.
Absorption of Inorganic and Haemoglobin Iron in Coeliac Disease (1977)

S ummary . Absorption from a 5 mg dose of iron as Fe ++ or haemoglobin iron was studied using a Total Body Counter in control subjects and patients with coeliac disease. In both groups the majority of subjects were iron deficient. Thirteen control subjects, 13 patients with untreated coeliac disease and 14 on treatment with gluten‐free diet had both absorption tests. Absorption of Fe ++ iron was reduced in untreated coeliac disease. This was particularly significant in iron deficient patients. Absorption was improved on treatment with gluten‐free diet. In contrast, the absorption of haemoglobin iron was not affected in coeliac disease, indicating that absorption of iron in this form is not dependent on the integrity of the mucosa of the proximal small bowel.
Predicting Localized Corrosion in Seawater Cooling Systems (2002)

Abstract A number of alloys are used as heat exchanger materials in seawater cooling systems, including stainless steels, aluminum, and nickel-based alloys. The localized corrosion of these materials is affected by temperature, microbial activity, chlorination, flow rate, and geographic location. A predictive model is presented and compared to field experiences of these alloys in seawater systems.
Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones (1998)

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R (IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.
The Chemical Composition of Honey (2007)

Honey is a supersaturated sugar solution, created by bees, and used by human beings as a sweetener. However, honey is more than just a supersaturated sugar solution; it also contains acids, minerals, vitamins, and amino acids in varying quantities. In this article, we will briefly explore the chemical composition of honey.
Microdefects and minority carrier diffusion lengths in II‐VI wide‐gap semiconductors (1998)

This paper evaluates the crystallinity of ZnSe semiconductor crystals (grown on the GaAs substrate by MBE), which are a suitable material for blue LD devices from the viewpoints of carrier diffusion length (lifetime) and microdefects, which are important parameters of the device. The effects of doping, lattice mismatch, n- and p-impurities, and the introduced amount on the crystallinity are investigated. As a result of experiments, it is seen that there exists the recombination center (HI level) related to the active nitrogen as the impurity, in addition to the effects of the mixed crystal and lattice mismatch, especially in the p-type ZnSe, which produces a remarkable degradation of the crystallinity (carrier diffusion length and the lifetime). © 1998 Scripta Technica, Electron Comm Jpn Pt 2, 81(10): 55–64, 1998
Synthesis of Cul-De-Sac Filter Networks Utilizing Hybrid Couplers (2007)

A synthesis procedure is described for the design of Cul-De-Sac networks realizing either bandpass or bandstop filter characteristics. The prototypes comprise a pair of one-port ladder sub-networks each connected at one of the coupled ports of a 3-dB, 90deg or 180deg hybrid coupler. Numerical examples and simulated filter layouts are presented to illustrate the design methodology
Effect of Trace Amounts of Water in the Mobile Phase of Normal-Phase Enantioselective High-Performance Liquid Chromatography on Selectivity and Resolution of Optical Isomers (2009)

The irreproducibility of normal-phase enantioselective high-performance liquid chromatography (HPLC) could be attributed to the presence or absence of trace amounts of water in one or more components of the mobile phase. The effect of trace amounts of water on chromatographic characteristics in normal-phase enantioselective HPLC was investigated by deliberate addition of controlled, trace amounts of water into the mobile phase for the separation of T-3811ME and its undesired enantiomer. Commercial 2-propanol was pre-mixed with 2% (v/v) water and then used for preparation of the mobile phase in combination with such organic modifiers as ethanol and methanol at different ratios. The results showed up to 30% improvement in the resolution (Rs), 4% in selectivity (alpha), and 39% in efficiency (plate number N) compared to using a mobile phase prepared from neat commercial 2-propanol. Thus, the effect of trace amounts of water in the mobile phase of normal-phase enantioselective HPLC was demonstrated.
UN ENFOQUE DE LAS LEYES FINANCIERAS A TRAVÉS DE LAS DISTRIBUCIONES DE CAPITAL (1997)

RESUMEN: El objetivo de este articulo es ofrecer un nuevo enfoque de las leyes financieras a traves del concepto de renta o distribucion de capital. Asi, construimos la Matematica Financiera desde el concepto de renta y tratamos de caracterizar los principales sistemas financieros que pueden presentarse en la practica: sumativos, multiplicativos y estacionarios. De este modo, aportamos nuestro punto de vista y nuestra metodologia a la elaboracion de un concepto que ha sido estudiado en relacion con las ecuaciones diferenciales, los factores, las funciones de distribucion de variables aleatorias, las curvas de indiferencia y el interes. Por ultimo, generalizamos el estudio a las rentas aleatorias e introducimos el concepto de ley financiero - aleatoria. PALABRAS CLAVE: Ley financiera; Renta; Distribucion de capital; Sistema financiero; Estacionario; Sumativo; Multiplicativo.
SOFTWARE APPLICATION FOR SUPPORTING OF CAE IN PROCESS ENGINEERING: AUTOMATED CHOICE OF THE SUITABLE REBOILER TYPE (2009)

Abstract preview not available - see full-text PDF article.
Information-based models for ad hoc IR (2010)

We introduce in this paper the family of information-based models for ad hoc information retrieval. These models draw their inspiration from a long-standing hypothesis in IR, namely the fact that the difference in the behaviors of a word at the document and collection levels brings information on the significance of the word for the document. This hypothesis has been exploited in the 2-Poisson mixture models, in the notion of eliteness in BM25, and more recently in DFR models. We show here that, combined with notions related to burstiness, it can lead to simpler and better models.
833 Evolution of sleep disordered breathing types in heart failure (2021)

Abstract Introduction Central sleep apnea is commonly seen in patients with heart failure. Here we present a case demonstrating shifting of predominant apneic events from central to obstructive type after placement of left ventricular assist device (LVAD) in end stage heart failure patient. Report of case(s) Case Presentation: 66 year-old African American male has past medical history of chronic congestive heart failure diabetes, hypertension, paroxysmal atrial fibrillation, anemia, hypothyroidism, chronic kidney disease and sleep apnea. Prior to his LVAD placement, his left ventricular ejection fraction (EF) was &lt;10%. Patient was diagnosed with central sleep apnea with AHI of 58 (with 92% of apneic events being central events), oxygen nadir of 74%. Subsequently, patient had LVAD placed for symptomatic heart failure and repeat polysomnogram repeated at six month demonstrated an improved AHI of 45.8 with predominantly obstructive and mixed apneic events, with only 12.5% being central events. Conclusion This case report highlights not only the improvement of the sleep apnea in CHF treated with LVAD but also shows the shift of apneic events from predominantly central to obstructive type post LVAD. Support (if any) 1. Henein MY, Westaby S, Poole-Wilson PA, Cowie MR, Simonds AK. Resolution of central sleep apnoea following implantation of a left ventricular assist device. Int J Cardiol. 2010 Feb 4;138(3):317–9. PMID: 18752859. 2. Köhnlein T, Welte T, Tan LB, Elliott MW. Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature. Thorax. 2002 Jun;57(6):547–54. PMID: 12037232 3. Monda C, Scala O, Paolillo S, Savarese G, Cecere M, D’Amore C, Parente A, Musella F, Mosca S, Filardi PP. Apnee notturne e scompenso cardiaco: fisiopatologia, diagnosi e terapia [Sleep apnea and heart failure: pathophysiology, diagnosis and therapy]. G Ital Cardiol (Rome). 2010 Nov;11(11):815–22. Italian. PMID: 21348318.
A 15-kD Interferon-Induced Protein and Its 17-kD Precursor: Expression in <i>Escherichia coli</i> , Purification, and Characterization (1989)

Using recombinant DNA technology, a 15-kD interferon (IFN)-induced protein and its 17-kD precursor have been expressed in Escherichia coli to obtain sufficient quantities of each protein for the investigation of their biological roles. Both the 15-kD and 17-kD proteins have been purified to homogeneity and crystallized. The recombinant 15-kD protein has an identical reversed-phase HPLC elution profile to that of the native 15-kD protein purified from human cells. Furthermore, the recombinant 15-kD and 17-kD proteins have identical amino- and carboxy-terminal amino acid sequences to those predicted from the DNA sequence. The native and recombinant 15-kD proteins give identical tryptic peptide maps, and the recombinant 17-kD protein gives only one additional tryptic peptide. We conclude that the recombinant 17-kD and 15-kD proteins are identical to the 17-kD precursor and the 15-kD stable product synthesized in human cells in response to IFN stimulation. In addition, we have demonstrated that the recombinant 17-kD precursor protein can be converted to the 15-kD protein by cytoplasmic extracts of human cells.