gebhart/patrepeval huggingface dataset:
Integrated simulation and emulation platform for cyber-physical system security experimentation (2012)

There is a pressing need to evaluate both cyber- and physical systems together and holistically for a rapidly growing number of applications using simulation and emulation in a realistic environment, which brings realistic attacks against the defensive capabilities of CPS (Cyber-Physical System). Without the support from appropriate tools and run-time environments, this assessment process can be extremely time-consuming and error-prone, if possible at all. In this paper, we present iSEE - integrated Simulation and Emulation platform for security Experimentation, as a "software supporting research infrastructure used for cyber security research and development". iSEE allows for the concurrent modeling, experimentation and evaluation of CPS that range from a fully simulated to a fully implemented system. iSEE has two major components: 1) modeling environment for system specification and experiment configuration and 2) run-time environment that supports experiment execution. iSEE employs the Model-Integrated-Computing (MIC) approach, which explicitly uses models throughout the experiment environments and integrates them at the domain-specific model level. The run-time environment of iSEE integrates Matlab and the DETERlab testbed to support realistic assessment of CPS on real distributed networking environments in its early design phase, before a fully implemented system is available. At run time, iSEE provides time synchronization and data communication and coordinates the execution of the security experiment across simulation and emulation platforms.
Effect of water temperature on the clinical outcome of infection with Edwardsiella ictaluri in channel catfish (1987)

Channel catfish fingerlings (mean body weight, 19 +/- 3 g each) were given intraperitoneal inoculations of Edwardsiella ictaluri suspensions of 10(4), 10(5), or 10(6) bacteria. Control fish were inoculated intraperitoneally with sterile 0.85% NaCl solution. Ten-day trials were conducted at water temperatures of 17, 21, 23, 25, 28, and 32 C. Differences in mortality between E ictaluri-infected fish and fish used as controls were observed at water temperatures of 23, 25, and 28 C, but not at temperatures of 17, 21, and 32 C. Clinical signs and lesions induced by intraperitoneal inoculation of E ictaluri were comparable with those found with the intestinal form of the natural disease. The characteristic erosion of skin and muscle overlying the skull, known as the "hole-in-the-head" lesion, was not observed. A given fish may be susceptible to infection at any water temperature, but a population is at risk when water temperatures are in the 22 to 28 C range.
Osmotic stress activates distinct lipid and MAPK signalling pathways in plants (2001)

Plants are continuously exposed to all kinds of water stress such as drought and salinity. In order to survive and adapt, they have developed survival strategies that have been well studied, but little is known about the early mechanisms by which the osmotic stress is perceived and transduced into these responses. During the last few years, however, a variety of reports suggest that specific lipid and MAPK pathways are involved. This review briefly summarises them and presents a model showing that osmotic stress is transmitted by multiple signalling pathways.
APC Gene Mutations in Human Prostate Cancer (1996)

Prostate cancer is the most common cancer in aged men. Although ras and p53 gene mutations have been detected in some prostate cancers, the major genetic alterations involved in its carcinogenesis are not well understood. Mutation of the APC gene is responsible for colorectal tumors in which ras and p53 mutations are also often involved. Using PCR-SSCP analysis and sequencing, we examined 31 human primary prostate cancers (three cases at stage A, 10 at stage B, five at stage C and 13 at stage D) and four cases of lymph node metastasis from the stage D cases, for mutations in the APC gene. A mutation was detected in only one of the 35 samples (3%). This mutation, present in a primary stage B cancer, had a T to C transition in exon 15 at the first position of codon 956, resulting in substitution of histidine for tyrosine. This study clarified that APC gene mutations are not largely involved in the development of clinical prostate cancer.
Programming HD-DVD and Blu-ray Disc : the HD cookbook (2008)

The ultimate book/DVD package for HD and Blu-Ray DVD applications This complete book/DVD package covers everything you need to know in order to write opticalworking code for HD and Blu-Ray DVD applications.This comprehensivetutorial not only teaches the new programming skillsbut also includes large chunks of reusable code anddemonstrates actual code outcomes.
Genome‐wide study of <scp>mRNA</scp> degradation and transcript elongation in <i> <scp>E</scp> scherichia coli </i> (2015)

An essential part of gene expression is the coordination of RNA synthesis and degradation, which occurs in the same cellular compartment in bacteria. Here, we report a genome-wide RNA degradation study in Escherichia coli using RNA-seq, and present evidence that the stereotypical exponential RNA decay curve obtained using initiation inhibitor, rifampicin, consists of two phases: residual RNA synthesis, a delay in the interruption of steady state that is dependent on distance relative to the mRNA's 5' end, and the exponential decay. This gives a more accurate RNA lifetime and RNA polymerase elongation rate simultaneously genome-wide. Transcripts typically have a single RNA decay constant along all positions, which is distinct between different operons, indicating that RNA stability is unlikely determined by local sequences. These measurements allowed us to establish a model for RNA processing involving co-transcriptional degradation, providing quantitative description of the macromolecular coordination in gene expression in bacteria on a system-wide level.
Electrical Still-Picture Camera Using Magnetic Bubble Memory (1982)

The characteristics of solid-state image sensors have made rapid improvements in the past several years and have come close to satisfying the requirements for home TV cameras. The application of solid-state image sensors to electronic still-picture camera has recently come onto the scene.
A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene (1990)

Cell specific expression of the insulin gene is achieved through transcriptional mechanisms operating on multiple DNA sequence elements located in the 5' flanking region of the gene. Of particular importance in the rat insulin I gene are two closely similar 9 bp sequences (IEB1 and IEB2): mutation of either of these leads to 5-10 fold reduction in transcriptional activity. We have screened an expression cDNA library derived from mouse pancreatic endocrine beta cells with a radioactive DNA probe containing multiple copies of the IEB1 sequence. A cDNA clone (A1) isolated by this procedure encodes a protein which shows efficient binding to the IEB1 probe, but much weaker binding to either an unrelated DNA probe or to a probe bearing a single base pair insertion within the recognition sequence. DNA sequence analysis indicates a protein belonging to the helix-loop-helix family of DNA-binding proteins. The ability of the protein encoded by clone A1 to recognize a number of wild type and mutant DNA sequences correlates closely with the ability of each sequence element to support transcription in vivo in the context of the insulin 5' flanking DNA. We conclude that the isolated cDNA may encode a transcription factor that participates in control of insulin gene expression.
Piezo-driven deformable mirror for femtosecond pulse shaping (2004)

We have developed a deformable, gold-coated mirror based on piezoelectric actuators with 15-micros response time. With 20 independent channels we were able to compress 72-fs pulses from a Ti:sapphire oscillator down to 45 fs in a 4f zero-dispersion compressor arrangement. Spectral interference was used to measure the mirror performance, while the spectral phase interferometry for direct electric field reconstruction (SPIDER) technique was used for the laser pulse characterization.
Role of human cytochrome P450 3A4 in the metabolism of DA–8159, a new erectogenic (2004)

The purpose of this paper was to characterize cytochrome P450 (CYP) enzymes involved in N-dealkylation of a new oral erectogenic, DA-8159 to DA-8164, a major circulating active metabolite, in human liver microsomes and to investigate the inhibitory potential of DA-8159 on CYP enzymes. CYP3A4 was identified as the major enzyme responsible for DA-8159 N-dealkylation to DA-8164 based on correlation analysis and specific CYP inhibitor and antibody-mediated inhibition study in human liver microsomes, and DA-8159 metabolism in cDNA expressed CYP enzymes. There is the possibility of drug-drug interactions when prescribing DA-8159 concomitantly with known inhibitors or inducers of CYP3A4. DA-8159 was found to be only a very weak inhibitor of eight major CYPs (1A2, 2A6, 2C8, 2C9, 2C19, 2D6, 2E1 and 3A4), the largest inhibition occurring against CYP2D6 (IC5o 67.7 microM) in human liver microsomes. Drug-drug interactions would not be predicted on the basis of DA-8159 inhibiting the metabolism of coadministered drugs.
High-Power 0.8 µm InGaAsP/InGaP/AlGaAs Single Quantum Well Lasers with Tensile-Strained InGaP Barriers (1999)

We report the high-power operation InGaAsP/InGaP/AlGaAs separate confinement heterostructure single quantum well laser diodes of 0.8 µm wavelength with InGaAsP unstrained quantum well sandwiched by tensile-strained InGaP barriers grown on a GaAs substrate. High band-gap 0.6% tensile-strained barriers are used to form a low-absorption region of lasing light near a facet and to suppress the carrier leakage from a quantum well. The lasers with tensile-strained barriers show performance superior to those without tensile-strained barriers. The former have a record-high characteristic temperature of 226 K in the case of 0.78–0.87 µm laser diodes with Al-free active regions and a high maximum continuous-wave (CW) output power of 1.63 W, while the latter have a characteristic temperature of 186 K and a maximum CW output power of 1.28 W.
Clustering‐Triggered Emission of Nonconjugated Polyacrylonitrile (2016)

Intrinsic emission from nonconjugated polymers has attracted considerable attention owing to its fundamental importance and intensive applications in diverse fields. The emission mechanism, however, is still in debate. Herein, nonconjugated polyacrylonitrile (PAN) molecules are found to be virtually nonluminescent in dilute solutions, while being highly emissive when concentrated or aggregated as nanosuspensions, solid powders, and films, exhibiting distinct aggregation-induced emission (AIE) characteristics. Moreover, triplet emissions of delayed fluorescence and room temperature phosphorescence are detected from the solid powders. Such unique emission of nonconjugated PAN is ascribed to the formation of cyano clusters, which act as the exact chromophores. In these clusters, through space electronic interactions, namely overlap of π and lone pair (n) electrons among cyano groups extend the conjugation and meanwhile rigidify the molecular conformations, thus offering remarkable emission upon irradiation. The AIE phenomenon can also be well rationalized by the formation of cyano clusters together with conformation rigidification. And the triplet emissions shall be originated from the n-π* transition owing to the presence of lone pairs. It is believed that such clustering-triggered emission mechanism is instructive for further development of unorthodox luminogens.
Studies on the Chemical Constituents of Rutaceous Plants. Part LXIX. Cesium Fluoride-Mediated Claisen Rearrangement of Aryl Propargyl Ether. Exclusive Formation of 2-Methylarylfuran and Its Availability as a Masked Salicylaldehyde. (1992)

Claisen rearrangement of an aryl propargyl ether in the presence of CsF led to exclusive formation of 2-methylarylfuran in excellent yield. The result of a precise examination of the rearrangement is described. Satisfactory transformation of the 2-methylarylfuran to a salicylaldehyde derivative was achieved by stepwise oxidation. This combination of reactions serves as a useful method for regioselective introduction of a C1 unit at the ortho position of a phenol group.
Growth factors as drugs for neurological and sensory disorders (1996)

Partial table of contents: Motor Neuron Disease and Model Systems: Aetiologies, Mechanisms and Therapies (D. Price, et al.). Potential Utility of rhIGF-1 in Neuromuscular and/or Degenerative Disease (J. Vaught, et al.). Development of Neurotrophic Factor Therapy for Alzheimer's Disease (F. Hefti, et al.). Somatic Gene Therapy for Nervous System Disease (M. Tuszynski & F. Gage). Neurotrophic Factors in the Treatment of Peripheral Neuropathy (S. Apfel & J. Kessler). Growth Factors in the Treatment of Degenerative Retinal Disorders (T. Reh, et al.). Growth Factors as Potential Drugs for the Sensory Epithelia of the Ear (J. Corwin, et al.). The Problems of Delivering Neuroactive Molecules to the CNS (S. Tan & P. Aebischer). Closing Remarks (J. Kessler). Indexes.
Triphasic Release Model for Multilayered Gelatin Coatings That Can Recreate Growth Factor Profiles During Wound Healing (2001)

Multilayered gelatin coatings were created to mimic growth factor profiles that normally occur during fracture healing. A model was developed to relate crosslinking and loading of individual layers to protein release. Modeling was simplified by dividing release profiles into three phases. The diffusion-controlled phase was determined by calculating periods of constant diffusivity for each homogeneous layer within devices. Diffusivity was a power law function of crosslinking. Fick's second law of diffusion was then used to determine release during the diffusion-controlled phase. Secondary diffusivity was determined by summing resistances of each successive homogeneous layer. The initial burst phase was defined as events proceeding the diffusion-controlled phase. Percentage of drug burst was a linear function of crosslinking. Release during the degradation-controlled phase, events following diffusion-controlled phase, was estimated based on first order hydrolysis of crosslinks. The model predicted time-variant release of differently labeled protein measured experimentally, and it can be used to design coatings to recreate the cascade of biomolecules that determine natural bone repair.
Toward a Determination of the Critical Size of Ice Nuclei. A Demonstration by Grazing Incidence X-ray Diffraction of Epitaxial Growth of Ice under the C31H63OH Alcohol Monolayer (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward a Determination of the Critical Size of Ice Nuclei. A Demonstration by Grazing Incidence X-ray Diffraction of Epitaxial Growth of Ice under the C31H63OH Alcohol MonolayerJ. Majewski, R. Popovitz-Biro, K. Kjaer, J. Als-Nielsen, M. Lahav, and L. LeiserowitzCite this: J. Phys. Chem. 1994, 98, 15, 4087–4093Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/j100066a030https://doi.org/10.1021/j100066a030research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Differences and Molecular Immunohistochemical Parameters in the Subtypes of Infiltrating Ductal Breast Cancer (2008)

Breast cancer is a heterogeneous disease, and patients are categorized into subtypes according to gene expression. We studied the associations among molecular, immunohistochemical, and clinicopathologic features and their distribution according to the subtypes luminal, HER2, basal, and normal-like in 60 patients with invasive ductal breast carcinoma without distant metastasis at the time of diagnosis (M0). We evaluated the hypermethylation of the CDH-1, RASSF1A, SIAH-1 and TSLC-1 genes by methylation-specific polymerase chain reaction and the expression of p53, bcl-2, cyclin D1, E-cadherin, and beta-catenin proteins in tissue microarrays by immunohistochemical analysis. Expression of bcl-2 was associated with the luminal subtype (P=.003), and CDH-1 hypermethylation was present preferentially in HER2 tumors (P=.038). The basal subtype was characterized by the expression of beta-catenin (P=.003). The hypermethylation of CDH-1 and the expression of bcl-2, cyclin D1, and beta-catenin proteins differ among breast cancer subtypes.
Clinical Benefit of Lapatinib-Based Therapy in Patients with Human Epidermal Growth Factor Receptor 2–Positive Breast Tumors Coexpressing the Truncated p95HER2 Receptor (2010)

Lapatinib as a monotherapy or in combination with capecitabine seems to be equally effective in patients with p95HER2-positive and p95HER2-negative HER2-positive breast tumors.
Analytical placement (1991)

Article Analytical placement: A linear or a quadratic objective function? Share on Authors: Georg Sigl Institute of Electronic Design Automation, Department of Electrical Engineering, Technical University of Munich, D-8000 Munich 2, Germany Institute of Electronic Design Automation, Department of Electrical Engineering, Technical University of Munich, D-8000 Munich 2, GermanyView Profile , Konrad Doll Institute of Electronic Design Automation, Department of Electrical Engineering, Technical University of Munich, D-8000 Munich 2, Germany Institute of Electronic Design Automation, Department of Electrical Engineering, Technical University of Munich, D-8000 Munich 2, GermanyView Profile , Frank M. Johannes Institute of Electronic Design Automation, Department of Electrical Engineering, Technical University of Munich, D-8000 Munich 2, Germany Institute of Electronic Design Automation, Department of Electrical Engineering, Technical University of Munich, D-8000 Munich 2, GermanyView Profile Authors Info & Claims DAC '91: Proceedings of the 28th ACM/IEEE Design Automation ConferenceJune 1991 Pages 427–432https://doi.org/10.1145/127601.127707Online:01 June 1991Publication History 167citation908DownloadsMetricsTotal Citations167Total Downloads908Last 12 Months36Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Varactor Topologies for RF Adaptivity with Improved Power Handling and Linearity (2007)

Ultra linear silicon-on-glass varactor topologies with improved power handling and linearity have been realized. The resulting components include integrated bias networks and provide excellent low-loss performance for large capacitances (e.g. C=20pF Q>100 at 2 GHz with V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">cont</sub> =2 V). Using a novel center tap circuit the linearity has been improved for narrowband two-tone signals yielding measured IIP3V values above 75 V for tone spacings >10 kHz. By implementing two varactor stacks in series with integrated bias networks the power handing improves 4x, while the IIP3V doubles. The resulting devices can be used as flip-chip components enabling linear adaptive wireless applications.
Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives (2014)

Colorectal cancer remains one of the most common and lethal malignancies worldwide despite the use of various therapeutic strategies. A better understanding of the mechanisms responsible for tumor initiation and progression is essential for the development of novel, more powerful therapies. The traditional, so-called "stochastic model" of tumor development, which assumes that each cancer cell is tumorigenic, has been deeply challenged during the past decade by the identification of cancer stem cells (CSCs), a biologically distinct subset of cells within the bulk of tumor mass. This discovery led to the development of the hierarchical model of tumorigenesis which assumes that only CSCs have the ability to initiate tumor growth, both at primary and metastatic sites. This model implies that the elimination of all CSCs is fundamental to eradicate tumors and that failure to do so might be responsible for the occurrence of relapses and/or metastases frequently observed in the clinical management of colorectal cancer patients. Identification and isolation of CSCs is essential for a better understanding of their role in the tumorigenetic process and for the development of CSC-specific therapies. Several methods have been used for this purpose and many efforts have been focused on the identification of specific CSC-surface markers. This review provides an overview of the proposed roles of CSC in human colorectal tumorigenesis focusing on the most important molecules identified as CSC-specific markers in colorectal cancer and on the potential strategies for the development of CSC-targeted therapy.
Reaction Products, Directionalities, and mechanisms of Iron(I)-Mediated CH-, CC-, and CO-Bond Activation of Aliphatic Carboxylic Acids in the Gas Phase (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction Products, Directionalities, and mechanisms of Iron(I)-Mediated CH-, CC-, and CO-Bond Activation of Aliphatic Carboxylic Acids in the Gas PhaseDetlef Schroeder, Waltraud Zummack, and Helmut SchwarzCite this: J. Am. Chem. Soc. 1994, 116, 13, 5857–5864Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://doi.org/10.1021/ja00092a041Request reuse permissionsArticle Views232Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (994 KB) Get e-Alertsclose Get e-Alerts