gebhart/patrepeval huggingface dataset:
Chromosome 9 deletion in sporadic and familial melanomas in vivo. (1994)

Twenty microsatellite loci on chromosome 9 were analysed for allelic losses in DNAs from 30 uncultured melanomas from 25 patients, relative to DNA from autologous peripheral blood lymphocytes. All patients were constitutionally heterozygous at several loci, and loss of heterozygosity (LOH) affecting 9p was observed in melanoma DNAs from 18 individuals (72%). Observations of losses of identical alleles in different metastatic lesions from the same patients, and of LOH in a vertical growth phase primary melanoma, were consistent with previous reports of chromosome 9 deletion early in melanoma development. LOH data suggested the loss of entire copies of chromosome 9 in 11 cases, and the terminal deletion of all or a portion of 9p in six cases. A somatic interstitial deletion of 9p between D9S162 and D9S169 was seen in a familial melanoma. This 21 cM deleted region corresponded with the previously reported positions of homozygous deletions in melanoma cell lines, and of the familial melanoma susceptibility locus (MLM). As 16 of the 18 cases of 9p LOH in the present study were observed in individuals with no family history of melanoma, it is likely that the MLM locus plays a role in the development of most sporadic melanomas.
Electronic pre-distortion for advanced modulation formats (2005)

We discuss implementation and scaling aspects of electronic pre-distortion transmitters combating chromatic dispersion. We present results for a variety of optical amplitude and phase modulation formats. (2 pages)
Clinical, Laboratory, and MRI Analysis of Cellulite Treatment with a Unipolar Radiofrequency Device (2007)

Upper thigh skin cellulite can be improved with a new unipolar radiofrequency device. Histologic changes suggest skin tightening as the method of improvement. No undesired complications of the skin or lipid metabolism were noted.
Graphene Nano-“patches” on a Carbon Nanotube Network for Highly Transparent/Conductive Thin Film Applications (2010)

Freestanding carbon-based composite thin films, consisting of a carbon nanotube network patched with graphene sheets, were assembled by a solid-phase layer-stacking approach with ethanol wetting. The composite films are highly flexible, transparent, and conductive, showing a sheet resistance of 735 Ω/sq at 90% transmittance (at 550 nm). Under AM1.5 illumination, heterojunction solar cells made from the composite films and n-type silicon show a power conversion efficiency of up to 5.2%.
VLSI neural network with digital weights and analog multipliers (2002)

A VLSI feedforward neural network is presented that makes use of digital weights and analog multipliers. The network is trained in a chip-in-loop fashion with a host computer implementing the training algorithm. The chip uses a serial digital weight bus implemented by a long shift register to input the weights. The inputs and outputs of the network are provided directly at pins on the chip. The training algorithm used is a parallel weight perturbation technique. Training results are shown for a 2 input, 1 output network trained with an AND function, and for a 2 input, 2 hidden unit, I output network trained with an XOR function.
Amberlyst A-21 an Excellent Heterogeneous Catalyst for the Conversion of Carbonyl Compounds to Oximes (1997)

Abstract Oximes can be efficiently obtained at room temperature by simply dissolving the appropriate carbonyl compounds and hydroxylamine hydrochloride, in ethanol, with Amberlyst A-21 as catalyst. Good yields of oximes are obtained, in very short reaction times, even with polifunctionalized substrates.
Non‐random conformation of a mouse IgG<sub>2a</sub> monoclonal antibody at low pH (1991)

The pH dependence of the conformation of a mouse IgG2a, kappa monoclonal antibody (MN12) was investigated by several physical techniques, including fluorescence spectroscopy, near-ultraviolet and far-ultraviolet CD, and electric-field-induced transient birefringence measurements. The intensity of the intrinsic tryptophan fluorescence remained constant in the pH range from 3.5 to 10.0. A conformational alteration in the MN12 molecule was observed in the pH region between pH 3.5 and 2.5, as reflected by a substantial enhancement of the fluorescence quantum yield. This effect was more pronounced at high ionic strengths. The fluorescence emission was unaltered, indicating that the acid-induced conformational state is different from a completely unfolded state. This was confirmed by CD and fluorescence polarisation measurements. Iodide and acrylamide fluorescence quenching studies indicated a gradually increasing accessibility of MN12 tryptophan residues with decreasing pH. At low pH precipitation was observed in the presence of iodide. One rotational relaxation time (0.16-0.18 microseconds) was observed for MN12 by electric-field-induced transient birefringence measurements at low ionic strength. After exposure of MN12 to low pH for 1 h, the relaxation time was increased to 0.23 microseconds; a further increase to 0.30 microseconds was observed after 24 h. The combined results suggest an acid-induced expansion and enhanced flexibility of MN12, which eventually leads to irreversible aggregation.
Development progress on a microelectronic tactile facsimile reading aid for the blind (1969)

Progress is described on a reading aid for the blind which is intended to give the blind direct access to ordinary printed material. Operation principles and construction of the device are described. Recent reading performance of a subject on typed reading material is presented.
Effective Gypsum Scale Inhibitors for Flue Gas Desulfurization Applications (1988)

Abstract The control of calcium sulfate formation, precipitation, and scale inhibition/prevention are essential in flue gas desulfurization (FGD) operations. A benchtop method of evaluating gypsum scale inhibitors under simulated FGD conditions was devised. The influences of water chemistry, high gypsum saturation, and competitive ions were explored. Based on the data obtained, computer modeling successfully predicted the inhibitor dosage requirements necessary to achieve maximum performance in the field.
<i>Biomathematics.</i> By W. M. F<scp>eldman</scp>, M.D., B.S., M.R.C.P. (Lond.), F.R.A.S., F.R.S. (Ed.). Second edition. Charles Griffin and Co. Ltd., 1935. Pp. viii + 480 (1935)

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
Magmatic differentiation and assimilation in the Adirondack region (1914)

Research Article| January 01, 1914 Magmatic differentiation and assimilation in the Adirondack region WILLIAM J. MILLER WILLIAM J. MILLER Search for other works by this author on: GSW Google Scholar GSA Bulletin (1914) 25 (1): 243–264. https://doi.org/10.1130/GSAB-25-243 Article history received: 08 Jan 1914 first online: 02 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation WILLIAM J. MILLER; Magmatic differentiation and assimilation in the Adirondack region. GSA Bulletin 1914;; 25 (1): 243–264. doi: https://doi.org/10.1130/GSAB-25-243 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract IntroductionThe deep-seated conditions to which the present surface rocks of the pre-Cambrian area in northern New York were subjected when the tremendous molten masses were intruded into the thick Grenville sediments were decidedly favorable for both magmatic differentiation and assimilation. Probably few regions present any better opportunities for the study of such phenomena. It is the purpose of this paper to bring together published and unpublished observations bearing on these problems and to present certain conclusions which have an important bearing not only on Adirondack geology, but also on the broader problems of petrology.Particular acknowledgments are due Professors Cushing, Kemp, and Smyth, all of whose publications pertaining to the geology of the region are so familiar to the writer. During the past eight years the writer’s work has been largely confined to the southern half of the Adirondack region and has resulted in the detailed mapping of about . . . This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not currently have access to this article.
Singlet oxygen and epoxidation from the dehydration of hydrogen peroxide (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSinglet oxygen and epoxidation from the dehydration of hydrogen peroxideJulius Rebek, S. Wolf, and A. MossmanCite this: J. Org. Chem. 1978, 43, 1, 180–181Publication Date (Print):January 1, 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/jo00395a049https://doi.org/10.1021/jo00395a049research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of the Docking Algorithm Based on Tensor Train Global Pptimization (2015)

Eectiveness of modern rational new drugs development is connected with accurate modelling of binding between target-proteins responsible for the disease and small molecules (ligands) candidates to become drugs. The main modeling tools are docking programs for positioning of the ligands in the target proteins. Ligand positioning is realized in the frame of the docking paradigm: the ligand binds to the protein in the pose corresponding to the global energy minimum on the complicated multidimensional energy surface of the protein-ligand system. Docking algorithm on the base of the novel method of tensor train global optimization is presented. The respective novel docking program SOL-T is validated on the set of 30 protein-ligand complexes with known 3D structures. The energy of the protein-ligand system is calculated in the frame of MMFF94 force eld. SOL-T performance is compared with the results of exhaustive low energy minima search carried out by parallel FLM docking program on the base of Monte Carlo method using large supercomputer resources. It is shown that SOL-T docking program is about 100 times faster than FLM program, and SOL-T is able to nd the global minimum (found by FLM docking program) for 50% of investigated protein-ligand complexes. Dependence of SOL-T performance on the rank of tensor train decomposition is investigated, and it is shown that SOL-T with rank 16 has almost the same performance as SOL-T with rank 64. It is shown that the docking paradigm is true not for all investigated complexes in the frame of MMFF94 force eld.
The design and optimization of SOC test solutions (2001)

We propose an integrated technique for extensive optimization of the final test solution for System-on-Chip using Simulated Annealing. The produced results from the technique are a minimized test schedule fulfilling test conflicts under test power constraints and an optimized design of the test access mechanism. We have implemented the proposed algorithm and performed experiments with several benchmarks and industrial designs to show the usefulness and efficiency of our technique.
Solubility of CF<sub>2</sub>-Modified Polybutadiene and Polyisoprene in Supercritical Carbon Dioxide (2002)

The cloud-point behavior of fluorinated polyisoprenes (FPI) and fluorinated polybutadienes (FPBD) in supercritical fluid (SCF) CO2 are reported at temperatures from 60 to 170 °C and pressures from 1000 to 3000 bar. These fluorinated polymers were prepared by the addition of difluorocarbene (CF2) to the parent polydienes yielding a gem-difluorocyclopropane repeating unit, a segment containing both fluorine and a significant dipole moment. Neither the unmodified polyisoprene starting material nor the hydrogenated variant dissolves in CO2 up to temperatures of 155 °C and pressures of 2600 bar. Both FPI and FPBD dissolve in CO2, but pressures in excess of 1000 bar are needed to obtain a single phase. The PFI and PFBD cloud-point curves exhibit temperature minima at approximately 60 and 80 °C, respectively, likely due to an increase in CO2−CO2 and polymer−polymer interactions relative to polymer−CO2 interactions. As the amount of CF2 incorporation in FPI samples decreases, the cloud-point curves shift to higher pressures and to higher temperatures. In a series of FPBD samples, an increase in cloud-point pressure with increase in molecular weight is initially large for molecular weights less than 105 and then becomes much less at higher molecular weights, as also observed for other polymer−SCF solvent mixtures. This methodology for incorporation of fluorine into macromolecules leads to significant enhancement of solubility in CO2.
Real-time focal stack compositing for handheld mobile cameras (2014)

Extending the depth of field using a single lens camera on a mobile device can be achieved by capturing a set of images each focused at a different depth or focal stack then combine these samples of the focal stack to form a single all-in-focus image or an image refocused at a desired depth of field. Focal stack compositing in real time for a handheld mobile camera has many challenges including capturing, processing power, handshaking, rolling shutter artifacts, occlusion, and lens zoom effect. In this paper, we describe a system for a real time focal stack compositing system for handheld mobile device with an alignment and compositing algorithms. We will also show all-in-focus images captured and processed by a cell phone camera running on Android OS.
How oxygen attacks [FeFe] hydrogenases from photosynthetic organisms (2009)

Green algae such as Chlamydomonas reinhardtii synthesize an [FeFe] hydrogenase that is highly active in hydrogen evolution. However, the extreme sensitivity of [FeFe] hydrogenases to oxygen presents a major challenge for exploiting these organisms to achieve sustainable photosynthetic hydrogen production. In this study, the mechanism of oxygen inactivation of the [FeFe] hydrogenase CrHydA1 from C. reinhardtii has been investigated. X-ray absorption spectroscopy shows that reaction with oxygen results in destruction of the [4Fe-4S] domain of the active site H-cluster while leaving the di-iron domain (2Fe(H)) essentially intact. By protein film electrochemistry we were able to determine the order of events leading up to this destruction. Carbon monoxide, a competitive inhibitor of CrHydA1 which binds to an Fe atom of the 2Fe(H) domain and is otherwise not known to attack FeS clusters in proteins, reacts nearly two orders of magnitude faster than oxygen and protects the enzyme against oxygen damage. These results therefore show that destruction of the [4Fe-4S] cluster is initiated by binding and reduction of oxygen at the di-iron domain-a key step that is blocked by carbon monoxide. The relatively slow attack by oxygen compared to carbon monoxide suggests that a very high level of discrimination can be achieved by subtle factors such as electronic effects (specific orbital overlap requirements) and steric constraints at the active site.
Single-Frequency Fiber Amplifiers for Next-Generation Gravitational Wave Detectors (2017)

At the beginning of 2016, the first direct detection of a gravitational wave by a laser-based Michelson interferometer has been reported. So far, the number of confirmed detections has raised to three and will certainly increase further. Thereby, mankind has an amazing new tool to observe and study the universe, namely by gravitational wave astronomy. However, in order to develop their full potential, a more sensitive generation of earth-bound gravitational wave detectors will be required in the future. Current detectors are operating with solid-state laser systems at 1064 nm but higher output power levels and longer wavelengths will be required by next-generation detectors. The requirements with respect to the laser sources, e.g., on the beam quality and the linewidth, are very challenging and unique. In recent years, it has been demonstrated that single-frequency fiber amplifiers are a very attractive concept as next-generation gravitational wave detectors laser sources. This paper reviews, highlights, and summarizes the corresponding research results, in particular, regarding power scaling, noise properties, and coherent beam combination.
Adenomatoid odontogenic tumor associated with dentigerous cyst in posterior maxilla: A case report and review of literature (2010)

Adenomatoid odontogenic tumor (AOT)-a benign (hamartomatous) lesion of odontogenic origin-is an uncommon tumor which affects young individuals with a female predominance, mainly in the second decade. This lesion is most commonly located in the anterior maxilla and is usually associated with an impacted canine tooth. This is a case report of a 39-year-old female patient presented with a large AOT of the posterior maxilla associated with an impacted second molar - a very rare situation.
Compressed porous graphene particles for use as supercapacitor electrodes with excellent volumetric performance (2015)

This work presents a new class of porous graphene particles with a three-dimensional microscale network and an ultrahigh specific surface area (2590 m(2) g(-1)), which is obtained by the KOH activation of a compact graphene hydrogel. As supercapacitor electrodes, such porous graphene particles show high compressibility and little capacitance loss when subjected to a compressive force up to 40 MPa, yielding an excellent volumetric performance with an ionic liquid electrolyte. Such carbon materials show great promise for applications needing high volumetric energy.
Prostatic Acid Phosphatase as a Target Molecule in Specific Immunotherapy for Patients With Nonprostate Adenocarcinoma (2005)

Prostatic acid phosphatase (PAP) is one of the prostate-related antigens that are applicable to specific immunotherapy for patients with prostate cancer. In this study, we determined whether or not PAP could be a target molecule in specific immunotherapy for patients with nonprostate cancer. A variety of adenocarcinoma cell lines were examined for their PAP expression at the mRNA and protein levels by reverse transcription polymerase chain reaction and western blot analysis, respectively. Considerable percentages of colon, gastric, and breast cancer cell lines were found to be positive for PAP at both the mRNA and the protein levels. The PAP expression in cancer tissues was also confirmed by immunohistochemical staining. In addition, we examined whether cancer-reactive cytotoxic T lymphocytes (CTLs) could be induced from peripheral blood mononuclear cells (PBMCs) of human leukocyte antigen (HLA) A24+ nonprostate cancer patients by in vitro stimulation with a PAP peptide. As a result, tumor-specific CTLs could be induced from the PBMCs of HLA-A24+ colon and gastric cancer patients. Their cytotoxicity against HLA-A24+ cancer cells was dependent on PAP peptide-specific and CD8+ T cells. These findings indicate that PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.
Analytical theory for PMD-compensation (2000)

We derive exact analytical expressions for the expected pulse broadening in a fiber-optic transmission system suffering from both first- and higher order polarization mode dispersion (PMD). Furthermore, we quantify the influence of two simple PMD-compensation techniques.
MORE ON PARTITIONED POSSIBLY RESTRICTED LINEAR REGRESSION (1995)

This paper deals with the general partitioned linear regression model where the regressor matrix $X=\pmatrix{X_1 & X_2\cr}$ may be deficient in column rank, the dispersion matrix $V$ is possibly singular, $\beta^t=\pmatrix{\beta_1^t & \beta_2^t\cr}$ - being partitioned according to $X$ - is the vector of unknown regression coefficients, and $\beta_2$ is possibly subject to consistent linear equality or inequality restrictions. In particular, we are interested in the set of {\it generalized least squares (GLS) selections} for $\beta_2$. Inspired by Aigner and Balestra [1], as well as by Nurhonen and Puntanen [2], we also consider a specific reduced model and describe a scenario under which the set of GLS selections for $\beta_2$ under the reduced model equals the set of GLS selections for $\beta_2$ under the original full model. The results obtained in [2] and [1] for the unrestricted {\it standard} (full rank) regression model are reobtained as special cases.
Drogue tracking using 3D flash lidar for autonomous aerial refueling (2011)

Autonomous aerial refueling (AAR) is an important capability for an unmanned aerial vehicle (UAV) to increase its flying range and endurance without increasing its size. This paper presents a novel tracking method that utilizes both 2D intensity and 3D point-cloud data acquired with a 3D Flash LIDAR sensor to establish relative position and orientation between the receiver vehicle and drogue during an aerial refueling process. Unlike classic, vision-based sensors, a 3D Flash LIDAR sensor can provide 3D point-cloud data in real time without motion blur, in the day or night, and is capable of imaging through fog and clouds. The proposed method segments out the drogue through 2D analysis and estimates the center of the drogue from 3D point-cloud data for flight trajectory determination. A level-set front propagation routine is first employed to identify the target of interest and establish its silhouette information. Sufficient domain knowledge, such as the size of the drogue and the expected operable distance, is integrated into our approach to quickly eliminate unlikely target candidates. A statistical analysis along with a random sample consensus (RANSAC) is performed on the target to reduce noise and estimate the center of the drogue after all 3D points on the drogue are identified. The estimated center and drogue silhouette serve as the seed points to efficiently locate the target in the next frame.
THE ACCESS ALMANAC : CENSUS UNDERCOUNT (2001)

This article offers a preliminary look at the undercount rate for commuters in the 2000 U.S. census. Using 1990 census numbers, the author shows the rates at which commuters were undercounted in 22 metropolitan areas by mode, by family income and by minority population. The differential appears greatest for poor and minority commuters. That distorted picture could also distort policy decisions over which kind of transportation is needed most, especially when it comes to mass transit. Contains graphs and charts.