gebhart/patrepeval huggingface dataset:
Targeting Protein Phosphatase 1 in Heart Failure (2005)

ver the past three decades the treatment of heart failure has shifted from a palliative care approach to a more successful focus on neurohormonal modulation through drugs that inhibit ␤-adrenergic, angiotensin, and aldosterone signaling.Despite these relatively recent advances, the clinical syndrome of heart failure remains progressive in nature.This observation begs the question as to a unifying aberrancy in cardiomyocyte phenotype that occurs in heart failure.2][3][4] This slower decline has been attributed to a decrease in the Ca 2ϩ uptake into the sarcoplasmic reticulum (SR); and particularly with the relative role of phospholamban (PLB) and the SR Ca 2ϩ -ATPase (SERCA). 4,5][4][5][6] In this issue, Pathak and del Monte et al show that targeted inhibition of protein phosphatase 1 (PP1) by increased activity of its inhibitor, inhibitor-1 in the heart, results in enhanced contractility and is protective against the development of cardiac hypertrophy and heart failure stimulated by hemodynamic load. 7In failing hearts, the downregulation of adrenergic receptor and cAMP-dependent protein kinase signaling leads to the inactivation of inhibitor-1 which, in turn, results in increased activity of PP1. 7,8This activation of PP1 leads to the dephosphorylation of phospholamban thus reducing calcium uptake by SERCA-2a.In an important series of experiments in transgenic mice and using gene transfer in rats, Kranias, Hajjar, and colleagues now show that the targeted inhibition of protein phosphatase 1 by overexpression of inhibitor-1 enhances cardiac contractility under normal hemodynamic conditions as well as in response to adrenergic stimulation with isoproterenol.Moreover, the authors show that targeted gene transfer of active inhibitor-1 in rats results in marked attenuation of the functional and morphometric changes associated with chronic pressure overload.
Spontaneous Renal Allograft Acceptance Associated with “Regulatory” Dendritic Cells and IDO (2008)

MHC-mismatched DBA/2 renal allografts are spontaneously accepted by C57BL/6 mice by poorly understood mechanisms, but both immune regulation and graft acceptance develop without exogenous immune modulation. Previous studies have shown that this model of spontaneous renal allograft acceptance is associated with TGF-beta-dependent immune regulation, suggesting a role for T regulatory cells. The current study shows that TGF-beta immune regulation develops 30 days posttransplant, but is lost by 150 days posttransplant. Despite loss of detectable TGF-beta immune regulation, renal allografts continue to function normally for >200 days posttransplantation. Because of its recently described immunoregulatory capabilities, we studied IDO expression in this model, and found that intragraft IDO gene expression progressively increases over time, and that IDO in "regulatory" dendritic cells (RDC) may contribute to regulation associated with long-term maintenance of renal allografts. Immunohistochemistry evaluation confirms the presence of both Foxp3+ T cells and IDO+ DCs in accepted renal allografts, and localization of both cell types within accepted allografts suggests the possibility of synergistic involvement in allograft acceptance. Interestingly, at the time when RDCs become detectable in spleens of allograft acceptors, approximately 30% of these mice challenged with donor-matched skin allografts accept these skin grafts, demonstrating progression to "true" tolerance. Together, these data suggest that spontaneous renal allograft acceptance evolves through a series of transient mechanisms, beginning with TGF-beta and T regulatory cells, which together may stimulate development of more robust regulation associated with RDC and IDO.
Zur Blockierung des Ionenaustauschs monovalenter Kationen durch divalente Kationen an Glasoberflächen (1982)

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Inverse Graphics with Probabilistic CAD Models (2014)

Recently, multiple formulations of vision problems as probabilistic inversions of generative models based on computer graphics have been proposed. However, applications to 3D perception from natural images have focused on low-dimensional latent scenes, due to challenges in both modeling and inference. Accounting for the enormous variability in 3D object shape and 2D appearance via realistic generative models seems intractable, as does inverting even simple versions of the many-to-many computations that link 3D scenes to 2D images. This paper proposes and evaluates an approach that addresses key aspects of both these challenges. We show that it is possible to solve challenging, real-world 3D vision problems by approximate inference in generative models for images based on rendering the outputs of probabilistic CAD (PCAD) programs. Our PCAD object geometry priors generate deformable 3D meshes corresponding to plausible objects and apply affine transformations to place them in a scene. Image likelihoods are based on similarity in a feature space based on standard mid-level image representations from the vision literature. Our inference algorithm integrates single-site and locally blocked Metropolis-Hastings proposals, Hamiltonian Monte Carlo and discriminative data-driven proposals learned from training data generated from our models. We apply this approach to 3D human pose estimation and object shape reconstruction from single images, achieving quantitative and qualitative performance improvements over state-of-the-art baselines.
Tetramethylpyrazine in the Treatment of Cardiovascular and Cerebrovascular Diseases (1983)

Key Word Index Ligusticum wallichii - Umbelliferae - Tetramethylpyrazine - Angina pectoris - Acute Obliterative Cerebrovascular Disease - Vasodilating Effect - Thrombo-embolic Disease
Manipulating the energy levels of semiconductor quantum dots (1999)

Artificial atoms with up to five well-defined electronic shells are fabricated using self-assembled quantum dots (QD's) grown by molecular-beam epitaxy. State-filling spectroscopy of the zero-dimensional transitions between confined electrons and holes demonstrates that the energy levels are readily tunable. One to five confined levels, with an interlevel energy spacing between 25 and 90 meV, are obtained by adjusting the growth temperature or with post growth annealings. The uniformity and reproducibility of InAs/GaAs QD's are optimized by adjusting growth parameters affecting the evolution and the equilibrium shape of the QD's: the amount of strained material deposited, and the annealing time following the InAs deposition. Well-defined excited states are also obtained with stacked layers of vertically self-assembled QD's.
A Novel G Protein α Subunit Containing Atypical Guanine Nucleotide-binding Domains Is Differentially Expressed in a Molluscan Nervous System (1995)

We described the characterization of a novel G protein alpha subunit, G alpha a. cDNA encoding this subunit was cloned from the central nervous system of the mollusc Lymnaea stagnalis. The deduced protein contains all characteristic guanine nucleotide-binding domains of G alpha subunits but shares only a limited degree of overall sequence identity with known subtypes (approximately 30%). Moreover, two of the nucleotide-binding domains exhibit salient deviations from corresponding sequences in other G protein alpha subunits. The A domain, determining kinetic features of the GTPase cycle, contains a markedly unique amino acid sequence (ILIIGGPGAGK). In addition, the C domain is also clearly distinct (DVAGQRSL). The presence of a leucine in this motif, instead of glutamic acid, has important implications for hypotheses concerning the GTPase mechanism. In contrast to other G alpha subtypes, G alpha a has no appropriate N-terminal residues that could be acylated. It does contain the strictly conserved arginine residue that serves as a cholera toxin substrate in G alpha s and G alpha t but lacks a site for ADP-ribosylation by pertussis toxin. In situ hybridization experiments indicate that G alpha a-encoding mRNA is expressed in a limited subpopulation of neurons within the Lymnaea brain. These data suggest that G alpha a defines a separate class of G proteins with cell type-specific functions.
Making CDN and ISP Routings Symbiotic (2011)

Internet Service Providers (ISPs) route traffic at the IP layer with the preference of less inter-carrier payments while Content Distribution Networks (CDNs) route traffic at the application layer with the preference of better application performance. Such mismatch of routing preferences leads to conflicts that eventually result in higher operational cost for both ISPs and CDNs. In this paper, we propose to make CDN and ISP routing mutually beneficial through ISP's non-uniform bandwidth charging and CDN's bandwidth cost-aware request routing. More specifically, ISPs charge different prices for traffic that traverses different types of inter domain links and CDNs, in routing user requests to their servers, try to minimize their ISP payments by taking the pricing information into consideration. We evaluate the solution in large scale simulations. The greedy solution presents the lowest bandwidth cost for CDNs but at the expense of network performance for users. With end-to-end delay introduced as a constraint in the optimization process, the solution maintains good network performance for users while achieving significant savings in bandwidth cost. Compared with conventional nearest-available policy in CDN request routing, our solution moves significant amount of inter domain traffic from provider routes to peer or customer routes, reducing operational costs for ISPs and CDNs.
Cryptanalysis of a Knapsack Public Key Cryptosystem (2009)

Murakami and Nasako proposed a knapsack public key cryptosystem in 2008. They claimed that their proposal is secure against some known attacks. In this paper, we propose a cryptanalytic attack on the cryptosystem. We use a heuristic method to show that the secret key can be recovered with lattice reduction algorithms. Hence, their construction is insecure.
Molecular Signatures of Natural Selection (2005)

There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.
MScache: A buffer management scheme based on page-level address mapping for NAND-flash SSD (2015)

NAND Flash has been widely used in consumer electronic devices, especially in SSDs (Solid State Disks). However, with the process scaling down, its inherent imperfection will be more severe, such as the limited endurance, asymmetric speed of programming and read. While a traditional cache mechanism can improve the performance partly, it can't reduce the unnecessary writes to NAND Flash resulting from read miss; besides, it is still difficult for most current cache strategies to respond diverse patterns of access rapidly. In this paper, a novel Master and Slave Cache (MScache) based on page-level mapping and hybrid buffer management strategy is proposed to reduce the redundant writes to NAND Flash, improve access speed and prolong SSD's lifespan. We assess the scheme with three typical traces and three classical cache schemes are compared. The simulation results show that the proposed MScache can achieve dramatically writes and erases reduction.
Pharmacological effects of ivermectin, an antiparasitic agent for intestinal strongyloidiasis: its mode of action and clinical efficacy. (2003)

Ivermectin is an oral semi-synthetic lactone anthelmintic agent derived from avermectins isolated from fermentation products of Streptomyces avermitilis. Ivermectin showed a concentration-dependent inhibitory effect on motility of a free-living nematode, Caenorhabditis elegans (C. elegans). There exist specific binding sites having a high affinity for ivermectin in the membrane fraction of C. elegans, and a strong positive correlation was detected between the affinity for these binding sites and the suppressive effect on motility of C. elegans in several ivermectin-related substances. These results suggested that the binding to these binding sites is important for the nematocidal activity of ivermectin. In oocytes of Xenopus laevis injected with the Poly (A)(+) RNA of C. elegans, expression of a chloride channel, which is irreversibly activated by ivermectin, was recognized. The pharmacological properties of this channel suggest that the ivermectin-sensitive channel is a glutamate-activated chloride channel. As to the glutamate-activated chloride channel, two subtypes (GluCl-alpha and GluCl-beta) were cloned, suggesting these subtypes constitute the glutamate-activated chloride channel. These findings suggest that ivermectin binds to glutamate-activated chloride channels existing in nerve or muscle cells of nematode with a specific and high affinity, causing hyperpolarization of nerve or muscle cells by increasing permeability of chloride ion through the cell membrane, and as a result, the parasites are paralyzed to death. In experimental infections in sheep and cattle, ivermectin exhibited potent dose-dependent anthelmintic effects on Haemonchus, Ostertagia, Trichostrongylus, Cooperia, Oesphagostomum, and Dictyocaulus. Anthelmintic effects were reported also in dogs, horses, and humans infected with Strongyloides. In the clinical Phase III trial in Japan, 50 patients infected with Strongyloides stercoralis were administered approx. 200 microg/kg of ivermectin to be given orally twice at an interval of 2 weeks. As a result, the Strongyloides stercoralis-eradicating rate was 98.0% (49/50).
Connector design for 3D printed antennas (2016)

Due to a recent growth in 3D printing technology, engineers are able to fabricate affordable and versatile antennas; however, poorly matched antenna terminations continue to limit the capabilities of 3D printed antennas. In this paper a 3D printed bowtie antenna is considered and 3D cable connectors are designed and their performance has simulated. The effect of printer resolution is examined to design the most feasible termination.
Location-based request forwarding in a geo-fencing application with multiple providers (2015)

Geo-fencing applications provide mobile users with services, i.e. information or functionality, when the users are within certain geographical areas. Current development on geo-fencing applications allows different geo-fencing areas served by multiple service providers. This idea requires a service routerto forward requests from users to target service providers by considering the users' current locations. In this paper, we present a location-based request forwarding mechanism and its implementation on a service router. The mechanism includes a caching mechanism to make efficient the forwarding process.
`Queensland Earlisweet' Cherry Plum (1990)

Queensland Earlisweet' is an attractive, highly flavored cherry plum with small fruit that ripens. 14 days before 'Wilson'. It is being introduced because of its earliness to provide a lead into the early plum Season. It is
Stimulus generation for constrained random simulation (2007)

Constrained random simulation is the main workhorse in today 's hardware verification flows. It requires the random generation of input stimuli that obey a set of declaratively specified input constraints, which are then applied to validate given design properties by simulation. The efficiency of the overall flow depends critically on (1) the performance of the constraint solver and (2) the distribution of the generated solutions. In this paper we discuss the overall problem of efficient constraint solving for stimulus generation for mixed Boolean/integer variable domains and propose a new hybrid solver based on Markov-chain Monte Carlo methods with good performance and distribution.
Implementation Of Broadband Integrated Services Distribution Network (1987)

The issues involved in the design of a broadband integrated services distribution network which utilizes optical fibers in the subscriber loop are considered in this paper. A hybrid scheme is proposed which provides integrated access to ISDN and wideband services by delivering voice/data signals in a digital format, while using fan analog format for full motion video services to subscribers. The paper discusses implementation details of the network and provides a cost comparison to alternative options.
Neural Net Identification of Flow Regime using Band Spectra of Flow Generated Sound (1998)

Multiphase production log interpretation requires that the flow regime along hole in the wellbore is known. Flow regime is the cased-hole analogue of lithology. Knowledge of the flow regime will help to interpret tool signals, will help to evaluate the flow rate on a per phase basis, and will reduce post processing load by at least a factor of 10. Flow regime can be classified correctly by a neural net in up to 87% of all cases using 1/3 octave band spectra of flow generated sound. A neural net trained on commercially available tool data (noise cut's) appears to be too sensitive to the wellbore inclination. Hence, application of automated neural net interpretation of noise logs requires a new generation of noise logging tools.P. 93
Ferromagnetic tunnel junctions with plasma-oxidized Al barriers and their annealing effects (1998)

Cross-geometrical Ni–Fe/Co/Al–AlO/Co/Ni–Fe/Fe–Mn/Ni–Fe tunnel junctions were fabricated by magnetron sputtering. To form the insulating layer, an Al layer was reverse sputtered in an atmosphere of either oxygen or oxygen–argon mixture at low power after deposition. The oxidization time necessary to form an AlO barrier was much shorter than that by natural oxidization, lasting for only a half to a few minutes. By adding argon to oxygen, the oxidization was slowed down and high MR ratios were obtained for a wide range of time. A magnetoresistance (MR) ratio of 16% was observed in the as-deposited junction when the barrier was oxidized in oxygen plasma for 35 s. In addition, the MR ratio increased to 24% by annealing at 300 °C. In as-deposited junctions, the tunnel resistances were increased by increasing the plasma oxidization time, but the MR ratios gradually decreased. The estimated tunnel barrier width increased and the barrier height decreased with the plasma oxidization time. After annealing, the MR ratio increased only for those junctions oxidized for short times. This suggests that the remaining Al between the AlO and the Co surface plays an important role in the effects of annealing.
Facile Fabrication of Photochromic Dye–Conducting Polymer Core–Shell Nanomaterials and Their Photoluminescence (2003)

Photochromic dye (pyrene)–conducting polymer (polypyrrole) core–shell nanomaterials were fabricated using microemulsion micelles as nanoreactors. The adsorption state of pyrene was tunable over a wide range with a small pyrene loading because of the phase separation and the packing constraints of the pyrene crystal. This methodology provides a facile way to control the emission of organic dyes, and also presents a new concept of nanohybrids for electronic devices.
ON/OFF phase shift keying for chaos-encrypted communication using external-cavity semiconductor lasers (2002)

Synchronization phenomena of two chaotically emitting semiconductor lasers subject to delayed optical feedback are investigated. The lasers are unidirectionally coupled via their optical fields. Our experimental and numerical studies demonstrate that the relative optical feedback phase is of decisive importance: a characteristic synchronization scenario evolves under variation of the relative optical-feedback phase mediating cyclically between chaos synchronization in conjunction with coherent fields, and uncorrelated states in conjunction with incoherent fields. As a key result, we propose, and numerically demonstrate, a novel ON/OFF phase shift keying method opening up new perspectives for applications in communication systems using chaotic carriers.
Nano-featured highly interconnective macroporous elastic scaffolds for cardiovascular tissue engineering (2007)

The lack of suitable scaffolding materials and viable scaffold design is challenging the success of tissue engineering. In the present study, we developed a new scaffolding strategy using a secondary porogen, poly(ethylene glycol) dimethyl ether along with sieved salts based on traditional salt-leaching method. This new scaffolding technology could allow us to fabricate nano- featured highly interconnective macroporous biodegradable elastic scaffolds based on a newly developed crosslinked poly(l,8-octanediol citrate) (POC) for cardiovascular tissue engineering.
Kinetics of the Reaction between Silver Bromide and an Adsorbed Layer of Allyl-thiourea (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the Reaction between Silver Bromide and an Adsorbed Layer of Allyl-thioureaT. H. James and W. VanselowCite this: J. Phys. Chem. 1953, 57, 7, 725–729Publication Date (Print):July 1, 1953Publication History Published online1 May 2002Published inissue 1 July 1953https://pubs.acs.org/doi/10.1021/j150508a030https://doi.org/10.1021/j150508a030research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts