gebhart/patrepeval huggingface dataset:
Global gene analysis of oocytes from early stages in human folliculogenesis shows high expression of novel genes in reproduction (2012)

The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and maturation of primordial follicles are poorly understood but follicles once activated either continue growth or undergo atresia. We have isolated pure populations of oocytes from human primordial, intermediate and primary follicles using laser capture micro-dissection microscopy and evaluated the global gene expression profiles by whole-genome microarray analysis. The array data were confirmed by qPCR for selected genes. A total of 6301 unique genes were identified as significantly expressed representing enriched specific functional categories such as 'RNA binding', 'translation initiation' and 'structural molecule activity'. Several genes, some not previously known to be associated with early oocyte development, were identified with exceptionally high expression levels, such as the anti-proliferative transmembrane protein with an epidermal growth factor-like and two follistatin-like domains (TMEFF2), the Rho-GTPase-activating protein oligophrenin 1 (OPHN1) and the mitochondrial-encoded ATPase6 (ATP6). Thus, the present study provides not only a technique to capture and perform transcriptome analysis of the sparse material of human oocytes from the earliest follicle stages but further includes a comprehensive basis for our understanding of the regulatory factors and pathways present during early human folliculogenesis.
Reovirus and tumor oncolysis. (2007)

REOviruses (Respiratory Enteric Orphan viruses) are ubiquitous, non-enveloped viruses containing 10 segments of double-stranded RNA (dsRNA) as their genome. They are common isolates of the respiratory and gastrointestinal tract of humans but are not associated with severe disease and are therefore considered relatively benign. An intriguing characteristic of reovirus is its innate oncolytic potential, which is linked to the transformed state of the cell. When immortalized cells are transfected in vitro with activated oncogenes such as Ras, Sos, v-erbB, or c-myc, they became susceptible to reovirus infection and subsequent cellular lysis, indicating that oncogene signaling pathways are exploited by reovirus. This observation has led to the use of the virus in clinical trials as an anti-cancer agent against oncogenic tumors. In addition to the exploitation of oncogene signaling, reovirus may further utilize host immune responses to enhance its antitumor activity in vivo due to its innate interferon induction ability. Reovirus is, however, not entirely benign to immunocompromised animal models. Reovirus causes so-called "black feet syndrome" in immunodeficient mice and can also harm neonatal animals. Because cancer patients often undergo immunosuppression due to heavy chemo/radiation-treatments or advanced tumor progression, this pathogenic response may be a hurdle in virus-based anticancer therapies. However, a genetically attenuated reovirus variant derived from persistent reovirus infection of cells in vitro is able to exert potent anti-tumor activity with significantly reduced viral pathogenesis in immunocompromised animals. Importantly, in this instance the attenuated reovirus maintains its oncolytic potential while significantly reducing viral pathogenesis in vivo.
Trends in the application of dynamic allocation methods in multiarm cancer clinical trials (2009)

6550 Background: In multiarm oncology clinical trials there is always a risk that the treatment groups could be imbalanced for a prognostic factor, potentially biasing treatment comparisons and compromising the validity of the results. Stratified randomization (SR) is frequently used to reduce imbalances. Dynamic allocation (DA), also known as minimization, is a controversial and largely nonrandom method of treatment allocation that can incorporate more prognostic factors than traditional SR methods. Proponents argue that results from clinical trials implementing DA are potentially more credible, while opponents claim there is little added benefit, increased complexity, and the statistical properties are not fully understood. We reviewed multi-arm cancer trials published between 1995–2005 to describe trends in the application of DA methods. Methods: 476 clinical trials with at least 100 patients in each arm, published in 13 major journals were reviewed. Manuscripts were grouped by impact factor (IF) of the publishing journal into low (<10), medium (10–20) and high (20+) categories. Trial-specific factors associated with publication were collected along with details of allocation method. Results: 112 (24%) trials described using DA for assigning patients to treatment. 79% of trials employing DA methods included 3 or more stratification factors, compared with only 36% of other trials (p < 0.001). Reported use of DA was similar between industry and non-industry sponsored studies (p = 0.85) and by geographical region (p = 0.73). Of 364 trials which did not describe using DA, 103 (28%) reported using SR, but a statement describing stratification on at least one factor was included in 291 (80%) trials. A trend was observed that reported use of both DA (p = 0.072) and SR (p = 0.067) methods increased over time. DA was associated with publication in higher IF journals univariately (OR = 1.67, 95% CI 1.11–2.52, p=0.014) and after adjusting for identified prognostic factors (OR = 1.70, 95% CI 1.06–2.73, p = 0.028). No association between SR and higher IF journal publication was observed (p = 0.52 univariately and p = 0.44 adjusting for other factors). Conclusions: DA is frequently used in cancer clinical trials. Reported use of DA, but not SR, is associated with publication in high IF journals. No significant financial relationships to disclose.
Kapitel 1: Online! Ein Paradigmenwechsel (2021)

Hand auf Herz: Hätte man uns vor einem Jahr gefragt, ob LEGO® Serious Play® online funktionieren kann, die Antwort wäre „Nein“ gewesen. Wir haben uns geirrt und wurden eines Besseren belehrt. Denn die Pandemie zwang uns, gänzlich neue Wege zu gehen. Zusammen mit meinem Freund und Trainer Jens Dröge machten wir uns daran, die Grenzen dessen, was bislang mit LEGO® Serious Play® für möglich gehalten wurde, zu verschieben.
Decrease of adenosine A<sub>1</sub> receptor density and of adenosine neuromodulation in the hippocampus of kindled rats (2003)

Adenosine is a neuromodulator that has been proposed to be a major endogenous anticonvulsant acting via A1 receptors. We tested if implementation of kindling through stimulation of the amygdala affected A1 receptor-mediated neuromodulation in hippocampal slices taken from rats 4 weeks after the last stage 5 seizure. The A1 receptor agonist, N6-cyclopentyladenosine (CPA) (6-100 nm), inhibited field excitatory postsynaptic potential (fEPSP) slope with an EC50 of 19.1-19.5 nm in control and sham-operated rats, but was less potent in kindled rats (EC50 = 42.7 nm). This might result from a decreased number of A1 receptors in hippocampal nerve terminal membranes, because A1 receptor immunoreactivity decreased by 28 +/- 3% and the binding density of the A1 receptor agonist [3H]R-PIA decreased from 1702 +/- 64 to 962 +/- 78 fmol/mg protein in kindled compared with control rats. The tonic inhibition of hippocampal synaptic transmission by endogenous adenosine was also lower in kindled rats, because A1 receptor blockade with 50 nm 1,3-dipropyl-8-cyclopentyladenosine (DPCPX) enhanced fEPSP slope by 23 +/- 3% and theta-burst-induced long-term potentiation by 94 +/- 4% in control rats but was virtually devoid of effects in kindled rats. The evoked release of adenosine from hippocampal slices or nerve terminals was 56-71% lower in kindled rats probably due to the combined decrease in the capacity of adenosine transporters and decreased release of adenosine 5'-triphosphate (ATP), which was partially compensated by a higher extracellular catabolism of ATP into adenosine in kindled rats. These results indicate that, although adenosine might inhibit the onset of epileptogenesis, once kindling is installed, the efficiency of the adenosine inhibitory system is impaired.
Thermal Image Sensing Model for Robotic Planning and Search (2016)

This work presents a search planning system for a rolling robot to find a source of infra-red (IR) radiation at an unknown location. Heat emissions are observed by a low-cost home-made IR passive visual sensor. The sensor capability for detection of radiation spectra was experimentally characterized. The sensor data were modeled by an exponential model to estimate the distance as a function of the IR image's intensity, and, a polynomial model to estimate temperature as a function of IR intensities. Both theoretical models are combined to deduce a subtle nonlinear exact solution via distance-temperature. A planning system obtains feed back from the IR camera (position, intensity, and temperature) to lead the robot to find the heat source. The planner is a system of nonlinear equations recursively solved by a Newton-based approach to estimate the IR-source in global coordinates. The planning system assists an autonomous navigation control in order to reach the goal and avoid collisions. Trigonometric partial differential equations were established to control the robot's course towards the heat emission. A sine function produces attractive accelerations toward the IR source. A cosine function produces repulsive accelerations against the obstacles observed by an RGB-D sensor. Simulations and real experiments of complex indoor are presented to illustrate the convenience and efficacy of the proposed approach.
Bond Order and Charge Localization in Nucleoside Phosphorothioates (1985)

In the recent literature on nucleoside phosphorothioate anions the structural formulas show a double bond between phosphorus and sulfur and a single bond between phosphorus and oxygen with a negative charge localized on oxygen. However, a review of physical data on these compounds shows the reverse to be the case; that is, in phosphorothioate anions the P-S bond is a single bond with a negative charge localized on sulfur, while the P-O bond order for exocyclic and nonbridging oxygens is greater than 1, approaching 2 in O-alkyl phosphorothioate monoanions and O,O-dialkyl phosphorothioates. The P-O bond orders in phosphorothioate dianions and trianions approach 1 1/2 and 1 1/3, respectively, owing to delocalization of negative charge among two or three oxygens. These conclusions are based on bond lengths obtained from x-ray crystallographic data and electron diffraction, the magnitudes of the effects of 18O on the 31P-nuclear magnetic resonance chemical shifts of phosphorus in nucleoside [18O]phosphorothioates, the pH-dependence of 17O-NMR chemical shifts in [17O]phosphate and [17O]thiophosphate, the vibrational spectra of thiophosphate di- and trianions, and the pKa (dissociation constant) values for phosphoric and thiophosphoric acids.
Theistically-Mitigated Skepticism - Mark L. McPherran: The Religion of Socrates. (University Park: Pennsylvania State University Press, 1996. Pp. xii, 353. $35.00.) (1998)

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Unsaturated Amines. VIII. Dehydrogenation and Hydroxylation of 1-Methyldecahydroquinoline by Means of Mercuric Acetate<sup>1</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnsaturated Amines. VIII. Dehydrogenation and Hydroxylation of 1-Methyldecahydroquinoline by Means of Mercuric Acetate1Nelson J. Leonard, Lee A. Miller, and Paul D. ThomasCite this: J. Am. Chem. Soc. 1956, 78, 14, 3463–3468Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://pubs.acs.org/doi/10.1021/ja01595a054https://doi.org/10.1021/ja01595a054research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simulation of the fault management with Self Healing mechanism (case study: LTE Network in Banda Aceh Area) (2016)

Fault management becomes an important part of operation and maintenance procedure. Operator cellular needs to reduce the number of errors, such us degradation or outage to provide a good service quality of the network. An automation is one of challenges to make operation and maintenance procedure becomes simpler. This paper presents a simulation of the Self-Healing mechanism in LTE network with a case study in the Banda Aceh Area. Self-healing is a domain of Self-Organizing Network (SON) that aims to detect, recover and compensate outages as well as possible. The simulation results showed that as a result of resource planning is too efficient, then the neighboring cell could take over traffic from the cell who experienced failure, but only a small portion of traffic that can be taken over, which is an average of 35%.
Fludarabine monophosphate: a potentially useful agent in chronic lymphocytic leukemia. (1988)

Recent developments in experimental chemotherapy may benefit patients with chronic lymphocytic leukemia (CLL). Fludarabine monophosphate has shown promise in heavily pretreated patients with advanced CLL. The Southwest Oncology Group has recently completed a phase II investigation of fludarabine in 32 patients. The patient population had a median age of 63 years, median performance status of 1, and included patients with the following stages of the disease: stage 0-3 patients; stage I-5 patients; stage II-6 patients; stage III-4 patients; stage IV-14 patients. A total of 176 courses were administered. Myelosuppression was the most frequent toxicity observed with 13 patients having a decline in platelets, and 11 patients having some decline in granulocytes. Fludarabine monophosphate has had unequivocal antileukemic activity in a group of patients with advanced CLL.
Effects of orchids (<i>Orchis anatolica</i>) on reproductive function and fertility in adult male mice (2006)

<b>Aims: </b> The aim of the present study was to determine the effect of orchid bulbs on the reproductive system of male albino mice. <b>Methods: </b> Orchid bulb extract was fed to 20 male albino mice (5 g/mouse/day) for 35 days and compared with a similar number of mice as controls. Total testicular germ cell population, histometrical parameters, serum blood biochemistry and hormonal assay were determined. <b>Results: </b> The ingestion of orchid bulb by mice induced a significant increase in the following parameters: (i) testes and seminal vesicle weights; (ii) number of different testicular germ cell population including interstitial Leydig cells and fibroblasts; and (iii) testicular cell linage dynamics obtained from testes and cauda epidydimides. An important finding was that the ingestion of the orchid diet by male mice increased their fertility. This was indicated by an elevation in the number of impregnated females when allowed to mate with treated mice, an increase in the impregnation sites, and an increase in the number of viable fetuses and the offspring's male/female ratio. A slight significant increase in the testosterone and follicular stimulating hormone titers in the treated mice were found in their blood serum. In contrast, a decrease in the number of degenerating cells was observed. <b>Conclusions: </b> Orchid bulb treatment might play an important role in improving male reproductive potential and fertility. (Reprod Med Biol 2006; <b>5</b>: 269-276).
BOTOX and Physical Therapy in the Treatment of Piriformis Syndrome (2002)

Injection with botulinum toxin A is an effective adjunct to physical therapy in the treatment of piriformis syndrome. H-reflex prolongation by flexion, adduction, and internal rotation (FAIR test) beyond 1.86 msec (3 SD) of the mean is a clinical indication of piriformis syndrome.
Development of an Improved Time–Frequency Analysis-Based Nonintrusive Load Monitor for Load Demand Identification (2014)

In a smart house connected to a smart grid via advanced metering infrastructure, a nonintrusive load monitor (NILM) that identifies individual appliances by disaggregating composite electric load signal from the minimal number of sensors installed at the main distribution board in the field can be regarded as a part of a home/building energy management system. This type of load monitoring technique, not only for domestic but also for industrial applications, is relevant to electricity energy management and conservation issues. In this paper, an improved time-frequency analysis-based NILM composed of three system components, including data acquisition, transient feature extraction, and load identification, is proposed. The improved NILM proposed in this paper incorporates a multiresolution S-transform-based transient feature extraction scheme with a modified 0-1 multidimensional knapsack algorithm-based load identification method to identify individual household appliances that may either be energized simultaneously or be identified under similar real power consumption. For the load identification process, an ant colony optimization algorithm is employed to perform combinatorial search that is formulated as a modified 0-1 multidimensional knapsack problem. As shown from the experimental results, the improved NILM strategy proposed in this paper is confirmed to be feasible.
W-CDMA capacity and planning issues (2000)

Third generation (3G) mobile networks are due to become reality in the next few years as governments world-wide start to auction or `release' new spectrum to new and existing cellular operators. A major differentiation of 3G over second generation networks is the provision of multiple-data-rate services, higher spectrum efficiency and greater flexibility of the air interface. This paper addresses FDD W-CDMA planning and capacity estimation issues. As well as addressing the planning steps, link budgets and simplistic uplink capacity estimation the paper goes into more detail on simulation methods and considerations. Finally an example W-CDMA network, based on realistic site locations in central London, is provided. Capacity estimations are given with some indications of network stability and operating points.
Computer-aided modelling of three-dimensional maxillofacial tissues through multi-modal imaging (2012)

Recent developments in digital imaging techniques have allowed a wide spread of three-dimensional methodologies based on capturing anatomical tissues by different approaches, such as cone-beam computed tomography, three-dimensional photography and surface scanning. In oral rehabilitation, an objective method to predict surgical and orthodontic outcomes should be based on anatomical data belonging to soft facial tissue, facial skeleton and dentition (maxillofacial triad). However, none of the available imaging techniques can accurately capture the complete triad. This article presents a multi-modal framework, which allows image fusion of different digital techniques to create a three-dimensional virtual maxillofacial model, which integrates photorealistic face, facial skeleton and dentition. The methodology is based on combining structured light surface scanning and cone-beam computed tomography data processing. The fusion procedure provides multi-modal representations by aligning different tissues on the basis of common anatomical constraints.
Isolation from pig liver microsomes, identification by tandem mass spectrometry andin vitro immunosuppressive activity of an SDZ-RAD 17,18,19,20,21,22-tris-epoxide (2000)

Macrolide immunosuppressive drugs such as tacrolimus (FK506) and sirolimus (rapamycin) are compounds largely used in modern immunosuppressive therapy and considered as powerful immunosuppressive agents. Some of these molecules are still under clinical development as, for example, SDZ-RAD (40-O-(2-hydroxyethyl)rapamycin), an immunosuppressive drug closely related to rapamycin. SDZ-RAD has a molecular mass of 957.57 Da (C53H83NO14) and shares the same common intracellular receptor as tacrolimus, the FK-506 binding protein (FKBP-12). SDZ-RAD exerts its pharmacological effect by binding to a different effector protein, inhibits the S6p 70-kinase and interrupts a different signal transduction pathway than tacrolimus. Both SDZ-RAD and rapamycin are metabolized mainly by the cytochrome P-450 3A4-dependent mixed function oxygenase enzyme system to hydroxylated and demethylated metabolites. We describe here the isolation from pig liver microsomes of a novel SDZ-RAD metabolite identified by electrospray tandam mass spectrometry as a new SDZ-RAD 17,18,19,20,21,22-tris-epoxide metabolite. The in vitro immunosuppressive activity as measured by the mixed lymphocyte reaction is more or less comparable to that of SDZ-RAD, although its pharmacological mode of action may be different from that classically described for rapamycin.
A Hybird Algorithm of Two Kinds of Trust Region Methods (2013)

In this paper, we propose an algorithm for nonlinear optimization problem that employs both traditional trust region methods. When solving trust region sub-problem, the traditional trust region algorithm is within the trust region centered at the current iteration point, the two improved trust region algorithms are within the trust region centered at one point located in the direction of the negative gradient ∥gk∥. When the norm of the gradient is less than or equal to 102, we use the traditional trust region method, otherwise use the two improved trust region methods. Numerical results are given to show that the algorithm is efficient for the proposed method.
On line non-contact thickness measurement of flat rolled metals (2003)

Technology for highly accurate, reliable, easily maintainable, and extremely user-friendly noncontact thickness measurement for flat-rolling and processing applications is described. The technology is based on the principle of material absorption or attenuation of radiation in a controlled instrument. The thickness gage that performs this measurement is an integral part of the control loop system, ensuring product quality control and efficient process operation. It can be used to achieve tight thickness tolerances, improve yield, and optimize mill and process line operation. A discussion is presented of the radiation sources and detectors; signal processing input and output; compensation to eliminate measurement errors; indication, display, and data recording; communication; and profile measurement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Highly luminescent covalently bonded layered double hydroxide–fluorescent dye nanohybrids (2014)

Incorporation of fluorescein dye molecules into layered double hydroxide (LDH) nanoparticles to form nanocomposites has great potential for optical and biological applications.