gebhart/patrepeval huggingface dataset:
The predictive value of ERCC1 and p53 for the effect of panobinostat and cisplatin combination treatment in NSCLC (2015)

Cisplatin is one of the most common chemotherapeutic drugs for non-small cell lung cancer (NSCLC). However, the response rate is limited because of drug resistance. Histone deacetylase inhibitors (HDACis), which can alter DNA accessibility by regulating chromatin structure and inducing apoptosis, exhibit a synergistic action with cisplatin. However, no biomarkers that can predict the efficacy of the combination of HDACis and cisplatin have been reported. Our study found that panobinostat, an HDAC inhibitor, increased the cisplatin sensitivity of several NSCLC cell lines with low ERCC1 expression but not those with high ERCC1 expression or gain-of-function (GOF) p53 mutation despite of ERCC1 expression level. ERCC1 knockdown increased the cisplatin sensitivity of NSCLC cell lines with high ERCC1 expression without GOF p53 mutations. In addition, in low ERCC1 expression NSCLC cell lines, knockdown of GOF mutant p53 enhanced cisplatin sensitivity. Further double knockdown of ERCC1 and GOF mutant p53 but not ERCC1 knockdown alone increased the cisplatin sensitivity of cells with both high ERCC1 expression and GOF p53 mutations. Therefore, this study demonstrated that ERCC1 expression combined with p53 mutation status may determine the efficacy of cisplatin and HDACi combined therapy and guide the development of future NSCLC therapies.
Detection of inapparent nodule-transformed cells in the mammary gland tissues of virgin female BALB/cfC3H mice. (1978)

Theodore Roosevelt encloses several items for Senator Bristow and expresses displeasure at the "many small and mean things" carried out by President Taft.
Tunneling and nonuniversal conductivity in composite materials (1987)

A simple model based on interparticle tunneling conduction and a percolative network is shown to imply a diverging distribution of high resistors in the system. This distribution is expected to yield a nonuniversal behavior of the electrical conductivity. An experimental study of carbon black--polymer composites seems to confirm this expectation, as well as explaining why a nonuniversal behavior has not been observed in previous experimental studies on such composites.
Priority-based template matching intra prediction (2008)

Template matching intra prediction has been reported earlier, to generate intra prediction signal from wider reconstructed areas compared with H.264/AVC intra prediction. In this paper an improved intra prediction scheme which introduces priority-guided template matching is presented. The proposed method first calculates a priority value of each pixel on the border between the current to-be-predicted block and the reconstructed or predicted area, and then performs template matching for the template centered on the pixel with the highest priority among all the border pixels, in an iterative manner. Simulation results demonstrate that the proposed algorithm can save about 2% bitrate than the non-priority algorithm.
Somatic embryogenesis and development of synthetic seed technology (1991)

Abstract One promise of plant biotechnology is the ability to clonally produce large numbers of identical individuals at minimal expense. Somatic embryogenesis is theoretically the production system of choice due to its high efficiency. Somatic embryos resemble zygotic embryos in seed, which suggests that they may be processed to function as synthetic seed with regard to efficient storage and handling qualities. However, somatic embryos tend to develop asynchronously and do not reach a mature quiescent resting stage typical of seed. Additionally, somatic embryos develop naked without surrounding nutrient tissues and protective seed coats. This paper reviews research aimed at causing somatic embryos to functionally mimic seed and introduces basic concepts of seed physiology which will be of use to cell culturalists working in synthetic seed technology. Key words: somatic embryosynthetic seedartificial seedquiescencedormancyembryogenesisseed
An indirect fluorescent antibody technique for Haemophilus ducreyi. (1978)

An indirect fluorescent antibody technique which allows the detection of antibody against or the recognition of Haemophilus ducreyi has been developed. Heat inactivated antiserum was reacted uith prepared smears of Haimophilus species and selected organisms commonly associated with penile ulcerations. In serum absorbed with Haemophilus sp no fluorescence was observed with 156 heterologous organisms, but all six strains of bacteriologically confirmed H. ducreyi gave significant reactions with the absorbed anti-WD-68 serum.
A Randomised Crossover Trial of Clinical Algorithm for Oxygen Saturation Targeting in Preterm Infants with Frequent Desaturation Episodes (2014)

The observation that algorithm-based control did not improve time spent within the SpO2 target and alarm limits suggests nursing care has reached an optimum in the unit studied. Our finding indicates that significant modifications to the algorithm are likely to be necessary to improve target range compliance.
Speaker-independent word recognition using a neural prediction model (2002)

A speech recognition model called the neural prediction model (NPM) is proposed. The model uses a sequence of multilayer perceptrons (MLPs) as a separate nonlinear predictor for each class. It is designed to represent temporal structures of speech patterns as recognition cues. In particular, temporal correlation in successive feature vectors of a speech pattern is represented in the mappings formed as MLP input-output relations. Temporal distortion of speech is efficiently normalized by a dynamic-programming technique. Recognition and training algorithms are presented based on the combination of dynamic-programming and back-propagation techniques. Evaluation experiments were conducted using ten-digit vocabulary samples uttered by 107 speakers. A 99.8% recognition accuracy was obtained. This suggests that the model is effective for speaker-independent speech recognition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Self-powered visual ultraviolet photodetector with Prussian blue electrochromic display (2013)

A novel self-powered ultraviolet (UV) photodetector was successfully constructed through combining Pt-modified TiO2 nanotubes and Prussian blue (PB)-modified ITO, in which the existence of UV could be judged easily by naked eye with the aid of PB for electrochromic display. More importantly, it could also self-recover without UV light illumination.
Effects of bacillus Calmette-Guérin and interferon-α-2B on human bladder cancerin vitro (1997)

The cytolytic and anti-proliferative effects of bacillus Calmette-Guerin (BCG) and/or interferon-alpha-2b (IFN-alpha-2b) on 5 human bladder carcinoma cell lines, RT4, RT112, MGH, SD and J82, were determined. The cell lines showed different sensitivities to BCG and IFN-alpha-2b. BCG had direct dose-dependent cytolytic and anti-proliferative effects on MGH, J82 and SD (grade 3 cell lines), whereas RT4 and RT112 (grades 1 and 2, respectively) were less sensitive. Surprisingly, higher concentrations of BCG enhanced cell growth of RT4. IFN-alpha-2b also had cytolytic and anti-proliferative effects on all 5 cell lines. Thus, the RT4 and RT112 cell lines that were not sensitive to BCG were highly sensitive to IFN-alpha-2b. A combination of BCG and IFN-alpha-2b had additive anti-proliferative effects on MGH, J82 and RT112. Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) production by these 5 cell lines was measured after stimulation with BCG and/or IFN-alpha-2b, by ELISA immunoassays. Production of IL-6 and TNF-alpha was significantly increased in MGH and J82 cell lines by the combination of BCG and IFN alpha-2b. The enhanced cytolytic and anti-proliferative effects of the combination of BCG and IFN-alpha-2b may be related to the induction of cytokines.
Holographic time-of-flight measurements of the hole-drift mobility in a photorefractive polymer (1995)

The holographic time-of-flight (HTOF) technique is applied in a photorefractive polymer. The electric-field, temperature, and drift-length dependencies of the hole-drift mobility are shown to be consistent with previously published data. It is suggested that the shape of the HTOF signal reflects the degree of charge-transport disorder in this class of amorphous materials.
SELF-ALIGNED GATE JFETS FOR SMART MEMS -MODELING, DESIGN AND FABRICATION (1999)

Modeling, design, fabrication and characterization of Self-Aligned Gate JFET (SJFET) devices and circuits are reported. The problem of electrical isolation between devices on the same chip is solved through Self-Aligned Gate approach, enabling device integration at the application of standard bipolar discrete device technology (no epitaxy etc.). Therefore this approach offers several advantages compared to other isolation techniques (lower number of fabrication steps, lower process temperature budget, reduction of leakage problems, lower chip cost etc.) and is appropriate for application in microsystems. SJFETs are analyzed by 2D numerical device simulation. SJFET circuits are analyzed by device modeling based circuit simulation. SJFET differential amplifier circuit simulation is reviewed as an example. On the basis of modeling results, test SJFET structures were designed and fabricated. Measurements on test SJFET structures reveal reasonable agreement with modeling.
The Electrochromic Process at  WO 3 Electrodes Prepared by Vacuum Evaporation and Anodic Oxidation of W (1979)

The kinetics of the electrochromic process and the stability with different electrodes (evaporated film, electrodes obtained by anodic oxidation of W, polycrystalline, and single crystal) were studied. Cyclic voltammetry and chronoamperometry, together with optical absorption measurements in the electrochromic region were carried out. Impedance measurements at different frequencies of the (aq) interface were also made to compare the evaporated film and anodic oxide electrodes. These measurements showed that the electrochromic reaction at the anodic film was much faster than that at the evaporated film electrode (by about two to three orders of magnitude). This difference in the reaction rates reflects the difference in the rate of diffusion of H+ in the films. Infrared spectroscopic measurements of the films were carried out to obtain information about the water content of the films. The differences in the kinetic behavior of the electrochromic process at the two electrodes were attributed to differences in porosity and water content of these two films. The stability of the film toward dissolution in aqueous solution was also shown to depend on the quantity of water in the film. In addition electrochemical behavior in the electrochromic region was studied in several other systems, including systems which contain as the electrolyte but with nonaqueous solvents and systems which contain Li+, replacing H+, in nonaqueous solvents. The solvent and the cation both affect the kinetics of the electrochromic process and the stability of the amorphous films. The electrochromic process at single crystal and polycrystalline was also studied and compared to the behavior of the amorphous film electrodes.
Simplified multidose preparation of iodine-123-beta-CIT: a marker for dopamine transporters. (1995)

The results obtained by solid phase extraction are consistent with those obtained by the HPLC method; with the advantage that the SPE method does not require solvent extraction, evaporation under reduced pressure or HPLC purification.
Reconstitution of Phosphatidylserine Transport from Chemically Defined Donor Membranes to Phosphatidylserine Decarboxylase 2 Implicates Specific Lipid Domains in the Process (2004)

Phosphatidylserine (PtdSer) is transported from its site of synthesis in the endoplasmic reticulum to the locus of PtdSer decarboxylase 2 (Psd2p) in the Golgi/vacuole and decarboxylated to form phosphatidylethanolamine. Recent biochemical and genetic evidence has implicated the C2 domain of Psd2p and a membrane-bound form of the phosphatidylinositol binding/transfer protein, PstB2p, as essential for this transport process. We devised a reconstituted system in which chemically defined donor membranes function to transfer PtdSer to the biological acceptor membranes containing Psd2p. The transfer of PtdSer is poor when the donor membranes have a high degree of curvature but markedly enhanced when the membranes are relatively planar (> or =400-nm diameter). PtdSer transfer is also dependent upon both the bulk and the surface concentrations of the lipid, with pure PtdSer vesicles acting as the most efficient donors at all concentrations. The lipid transfer from donor membranes containing either 100% PtdSer or 50% PtdSer at a fixed concentration (e.g. 250 microM PtdSer) differs by a factor of 20. Surface dilution of PtdSer by choline, ethanolamine, glycerol, and inositol phospholipids markedly inhibits PtdSer transfer, whereas phosphatidic acid (PtdOH) stimulates the transfer. Most importantly, the transfer of PtdSer from liposomes to Psd2p fails to occur in acceptor membranes from strains lacking PstB2p or the C2 domain of Psd2p. These data support a model for PtdSer transport from planar domains highly enriched in PtdSer or in PtdSer plus PtdOH.
N-Nitrosoamides. V. N-Nitrosoamides of Secondary Carbinamines; An Example of Intramolecular Inversion of Configuration<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Nitrosoamides. V. N-Nitrosoamides of Secondary Carbinamines; An Example of Intramolecular Inversion of Configuration1Emil H. White and Carl A. Aufdermarsh Jr.Cite this: J. Am. Chem. Soc. 1961, 83, 5, 1179–1190Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/ja01466a041https://doi.org/10.1021/ja01466a041research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Determination of bisphenol-A using GC/MS in Can Materials (2001)

A new simple, rapid and sensitive gas chromatographic technique for the determination of bisphenol-A in can materials, which is the major material of epoxy resin and polycarbonate polymer, is proposed. This method is characterised by derivatization of the bisphenol-A with a acylating reagent forming the acetate derivative to optimize the chromatographic property. The detection of bisphenol-A is performed based on GC/MS (gas chromatography/mass spectrometry). Several beverages were analyzed by the proposed method for the determination of bisphenol-A Bisphenol-A was assayed the range of from the can materials.
Halide-Stabilized LiBH<sub>4</sub>, a Room-Temperature Lithium Fast-Ion Conductor (2009)

Solid state lithium conductors are attracting much attention for their potential applications to solid-state batteries and supercapacitors of high energy density to overcome safety issues and irreversible capacity loss of the currently commercialized ones. Recently, we discovered a new class of lithium super ionic conductors based on lithium borohydride (LiBH(4)). LiBH(4) was found to have conductivity as high as 10(-2) Scm(-1) accompanied by orthorhombic to hexagonal phase transition above 115 degrees C. Polarization to the lithium metal electrode was shown to be extremely low, providing a versatile anode interface for the battery application. However, the high transition temperature of the superionic phase has limited its applications. Here we show that a chemical modification of LiBH(4) can stabilize the superionic phase even below room temperature. By doping of lithium halides, high conductivity can be obtained at room temperature. Both XRD and NMR confirmed room-temperature stabilization of superionic phase for LiI-doped LiBH(4). The electrochemical measurements showed a great advantage of this material as an extremely lightweight lithium electrolyte for batteries of high energy density. This material will open alternative opportunities for the development of solid ionic conductors other than previously known lithium conductors.
Diode-pumped Nd:YAG master oscillator power amplifier with high pulse energy, excellent beam quality, and frequency-stabilized master oscillator as a basis for a next-generation lidar system (2005)

A pulsed, diode-laser-pumped Nd:YAG master oscillator power amplifier (MOPA) in rod geometry, frequency stabilized with a modified Pound-Drever-Hall scheme is presented. The apparatus delivers 33-ns pulses with a maximum pulse energy of 0.5 J at 1064 nm. The system was set up in two different configurations for repetition rates of 100 or 250 Hz. The beam quality was measured to be 1.5 times the diffraction limit at a pulse energy of 405 mJ and a repetition rate of 100 Hz. At 250 Hz with the same pulse energy, the M2 was better than 2.1. The radiation is frequency converted with an efficiency of 50% to 532 nm. This MOPA system will be the pump laser of transmitters for a variety of high-end, scanning lidar systems.
A Spherical DC Servo Motor With Three Degrees of Freedom (1989)

A spherical DC servo motor with three degrees of freedom is proposed. First, the process of generating three-dimensional torque is analyzed to obtain the torque constant matrix. The matrix elements are shown to vary with rotor inclination, and winding currents are shown to interfere with each other. Then, the dynamics of the spherical motor are investigated theoretically and experimentally, considering torque interference, gyro moment and gravity. Finally, the trajectory of the prototype motor is shown in order to clarify its abilities. This new spherical motor is expected to produce a smaller, a lighter mechanism, since no gears or linkages are needed.
Low 1/f noise and DC offset RF mixer for direct conversion receiver using parasitic vertical NPN bipolar transistor in deep n-well CMOS technology (2004)

RF characteristics of the parasitic vertical NPN bipolar junction transistor (BJT) available in 0.18 /spl mu/m foundry deep n-well CMOS technology are reported for the first time. The experimental results show that the vertical NPN BJT has about 20 of current gain, 7 V of collector-emitter breakdown voltage, 20 V of collector-base breakdown voltage, 40 V of early voltage, 2.3 GHz of cutoff frequency, and 3.5 GHz of maximum oscillation frequency at room temperature. The corner frequency of flicker noise is lower than 4 kHz at 0.5 mA. Double balanced RF mixer using V-NPN shows almost free 1/f noise as well as order of magnitude smaller DC offset with other characteristics comparable with CMOS one and 12 dB flat up to the cutoff frequency, opening the possibility of high performance direct conversion receiver implementation in CMOS technology.
Distribution of cytoskeletal proteins, integrins, leukocyte adhesion molecules and extracellular matrix proteins in plastic-embedded human and rat kidneys. (2001)

The above mentioned provides an excellent tool for the accurate localization of a wide variety of antigens at the light microscopic level.
Simultaneous Dynamic Pupil Coding with On-chip Coded Aperture Temporal Imaging (2014)

We describe a new sensor that combines dynamic pupil coding with a digital readout integrated circuit (DROIC) capable of modulating a scene with a global or per-pixel time-varying, pseudo-random, and duo-binary signal (+1-1,0).
An integrated approach for remanufacturing job shop scheduling with routing alternatives (2019)

Remanufacturing is a practice of growing importance due to increasing environmental awareness and regulations. However, the stochastic natures inherent in the remanufacturing processes complicate its scheduling. This paper undertakes the challenge and presents a remanufacturing job shop scheduling approach by integrating alternative routing assignment and machine resource dispatching. A colored timed Petri net is introduced to model the dynamics of remanufacturing process, such as various process routings, uncertain operation times for cores, and machine resource conflicts. With the color attributes in Petri nets, two types of decision points, recovery routing selection and resource dispatching, are introduced and linked with places in CTPN model. With time attributes in Petri nets, the temporal aspect of recovery operations for cores as well as the evolution dynamics in cores' operational stages is mathematically analyzed. A hybrid meta-heuristic algorithm embedded scheduling strategy over CTPN is proposed to search for the optimal recovery routings for worn cores and their recovery operation sequences on workstations, in minimizing the total production cost. The approach is demonstrated through the remanufacturing of used machine tool and its effectiveness is compared against another two cases: baseline case with fixed recovery process routings and case 2 using standard SA/MST.
Self-Powered Sensor for Trace Hg<sup>2+</sup> Detection (2011)

A self-powered electrochemical sensor has been facilely designed for sensitive detection of Hg(2+) based on the inhibition of biocatalysis process of enzymatic biofuel cell (BFC) for the first time. The as-prepared one-compartment BFC, which was consisted of alcohol dehydrogenase supported on single-walled carbon nanohorns-based mediator system as the anode and bilirubin oxidase as the cathodic biocatalyst, generated an open circuit potential (V(oc)) of 636 mV and a maximum power density of 137 μW cm(-2). It was interestingly found that the presence of Hg(2+) would affect the performance of the constructed BFC (e.g., V(oc)). Taking advantage of the inhibitive effect of Hg(2+), a novel self-powered Hg(2+) sensor has been developed, which showed a linear range of 1-500 nM (R(2) = 0.999) with a detection limit of 1 nM at room temperature. In addition, this BFC-type sensor exhibited good selectivity for Hg(2+) against other common environmental metal ions, and the feasibility of the method for Hg(2+) detection in actual water samples (i.e., tap, ground, and lake water) was demonstrated with satisfactory results.
Introduction (1983)

A variety of interrelated theoretical problems arising out of the study of cognition are examined in this book. At the heart of many of these problems are recurrent programmatic claims about the appropriateness of conceiving of human ‘cognitive conduct’ in terms of conceptual schemes borrowed from computer science. The ‘computational’ theory of mind and behaviour, and the related notions of persons as ‘information-processing systems’ and ‘sentient automata’, informs a great deal of contemporary research and theory construction in the field. As many commentators have noted,1 the leading alternative to behaviouristic strategies of description and explanation these days is some form of ‘cognitive’ model of conduct, and this is increasingly the case not only within human psychology, but within theoretical linguistics, philosophy of mind and action, microsociology and anthropology. Indeed, since the celebrated Chomsky-Skinner debate of the late nineteen fifties, one can trace a polarisation among theoreticians in the human sciences, if not a full-blown case of a ‘paradigm-shift’.