gebhart/patrepeval huggingface dataset:
Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients (1991)

Although altered cytokine homeostasis has been implicated in the pathogenesis of alcoholic liver disease, the relationship between cytokines and metabolic consequences of alcoholic liver disease is unknown. We, therefore, sought to correlate circulating concentrations of tumor necrosis factor-alpha, interleukin-1 and interleukin-6 to clinical and biochemical parameters of liver disease in chronic alcoholic patients. We used an enzyme-linked immunosorbent assay to measure plasma tumor necrosis factor and interleukin-1 and a bioassay to measure serum interleukin-6 in three groups of alcoholic men as follows: (a) actively drinking alcoholic men without evidence of chronic liver disease, (b) nondrinking alcoholic men with stable cirrhosis and (c) patients with acute alcoholic hepatitis. Mean cytokine concentrations were elevated in cirrhotic patients and alcoholic hepatitis patients compared with controls and alcoholic patients without liver disease. Tumor necrosis factor-alpha and interleukin-1 alpha concentrations remained elevated for up to 6 mo after diagnosis of alcoholic hepatitis, whereas interleukin-6 normalized in parallel with clinical recovery. Concentrations of all three cytokines were correlated with biochemical parameters of liver injury and hepatic protein synthesis plus serum immunoglobulin concentrations. We could not demonstrate a relationship between cytokine concentrations and peripheral endotoxemia. Percentages of peripheral blood monocytes that reacted with monoclonal antibodies to CD25 (interleukin-2 receptor) and human lymphocyte antigen-DR were similar for alcoholic patients and controls. These data suggest that tumor necrosis factor-alpha and interleukin-1 alpha are related to some of the metabolic consequences of both acute and chronic alcohol-induced liver disease, whereas interleukin-6 is related to abnormalities seen in acute liver injury.
Deep brain stimulation for movement disorders: Patient selection and technical options (2012)

Deep brain stimulation (DBS) is used as a treatment for movement disorders. Unlike ablative procedures, DBS is reversible and adjustable. It is approved in the United States for treatment of Parkinson disease (PD), dystonia, and tremor. This surgical procedure is considered safe and effective for the management of the motor symptoms of these disorders, although it does not cure the underlying conditions. Potential complications of DBS surgery include intracranial hemorrhage, infections, and complications related to the hardware. There may also be complications related to stimulation or programming, although these are usually associated with dosages of dopaminergic medications and are reversible. DBS is usually performed under conscious sedation with awake evaluation during intraoperative physiologic testing. Typically, the procedure is performed with stereotactic image guidance, using computed tomography or magnetic resonance imaging (MRI) for targeting. Surgery can be accomplished with stereotactic frames or frameless systems. Recently, intraoperative MRI guidance has become available and is an alternative to the traditional surgical procedure, allowing for implantation of the DBS device under general anesthesia.
Handling Qualities Evaluations of Low Complexity Model Reference Adaptive Controllers for Reduced Pitch and Roll Damping Scenarios (2011)

National Aeronautics and Space Administration (NASA) researchers have conducted a series of flight experiments designed to study the effects of varying levels of adaptive controller complexity on the performance and handling qualities of an aircraft under various simulated failure or damage conditions. A baseline, nonlinear dynamic inversion controller was augmented with three variations of a model reference adaptive control design. The simplest design consisted of a single adaptive parameter in each of the pitch and roll axes computed using a basic gradient-based update law. A second design was built upon the first by increasing the complexity of the update law. The third and most complex design added an additional adaptive parameter to each axis. Flight tests were conducted using NASA s Full-scale Advanced Systems Testbed, a highly modified F-18 aircraft that contains a research flight control system capable of housing advanced flight controls experiments. Each controller was evaluated against a suite of simulated failures and damage ranging from destabilization of the pitch and roll axes to significant coupling between the axes. Two pilots evaluated the three adaptive controllers as well as the non-adaptive baseline controller in a variety of dynamic maneuvers and precision flying tasks designed to uncover potential deficiencies in the handling qualities of the aircraft, and adverse interactions between the pilot and the adaptive controllers. The work was completed as part of the Integrated Resilient Aircraft Control Project under NASA s Aviation Safety Program.
Two different sialidases, KDN-sialidase and regular sialidase in the starfish <i>Asterina pectinifera</i> (1996)

We have found the coexistence of two different sialidases in the entrails of the starfish Asterina pectinifera: a regular sialidase (RS), which cleaves sialic acid from sialoglycoconjugates, and a KDN-sialidase (KS) which releases the sialic acid analogue KDN (2-keto-3-deoxy-D-glycero-d-galacto-nononic acid) from KDN-containing glycoconjugates that are resistant to RS. The 6700-fold purified KS and 1300-fold purified RS were prepared to study the properties of these two sialidases. KS and RS from Asterina starfish differ in several properties other than glycon specificity, including molecular mass, isoelectric point (pI) and susceptibility to competitive and non-competitive inhibitors. KS has a molecular mass of 31 kDa and a pI of 8.3 while RS has a molecular mass of 128 kDa and a pI of about 4.8. 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (NeuAc2en), but not 2,3-dehydro-2-deoxy-KDN (KDN2en), is a potent competitive inhibitor of RS (Ki approximately 0.007 mM); however, both NeuAc2en and KDN2en are moderate inhibitors of KS (K1 approximately 0.04 mM). Hg2+ is a potent non-competitive inhibitor of RS but not of KS. KS and RS were examined for their ability to hydrolyse KDN- and NeuAc-containing glycoconjugates. KS hydrolyses 4-methyl-umbelliferyl-alpha-KDN (MU-KDN) 20 times faster than 4-methylumbelliferyl-alpha-NeuAc (MU-NeuAc), while RS hydrolyses MU-NeuAc 88 times faster than MU-KDN at the pH optimum of 4.0 KS effectively hydrolyses KDN-GM3 (where GM3 is NeuAc alpha 2 --> 3Gal beta 1 --> 4Glc beta 1-1' Cer, and Cer is ceramide), KDN alpha 2 --> 3lactose, KDN alpha 2 --> 6lactose, KDN alpha 2 --> 6N-acetylgalactosaminitol, KDN alpha 2 --> 6 (KDN alpha 2 --> 3)N-acetylgalactosaminitol and KDN alpha 2 --> 6(GlcNAc beta 1 --> 3) N-acetylgalactosaminitol. However, under the same conditions, these KDN-containing glycoconjugates are refractory to RS. Conversely, GM3, NeuAc alpha 2 --> 3lactose and NeuAc alpha 2 --> 6lactose are effectively hydrolysed by RS but not by KS.
Protein C-Terminal Modification through Thioacid/Azide Amidation (2009)

The preparation of protein bioconjugates has been largely dependent on the development of selective chemistries that are orthogonal to the diverse functionalities present in a protein. Here, we report a new method for C-terminus-directed modification of recombinant proteins. The method is based on the thioacid/azide amidation reaction. Essentially, hydrothiolytic cleavage of the thioester intermediate in protein splicing yields a recombinant protein with a unique thioacid group at the C-terminus, which is then chemoselectively amidated with an electron-poor organic azide carrying a biofunctional tag. The small ubiquitin protein was used as a model system to demonstrate the utility of this new bioconjugation method. C-terminal PEGylation or biotinylation of ubiquitin was readily achieved through amidation of ubiquitin thioacid with a sulfonazide-functionalized PEG or biotin derivative. Our data validate that thioacid/azide amidation is a mechanistically novel and practically useful method for site-selective protein modification.
A discrete time quad-band GSM/GPRS receiver in a 90nm digital CMOS process (2006)

We present the receiver in the first single-chip GSM transceiver that incorporates full integration of quad-band receiver, transmitter, memory, power management, dedicated ARM processor and RF built-in self test in a 90 nm digital CMOS process. The architecture uses direct RF sampling in the receiver and an all-digital PLL in the transmitter. The receive chain uses discrete-time analog signal processing to down convert, down- sample, filter and analog-to-digital convert the received signal. An auxiliary feedback is provided at the mixer output that can linearize the entire receive chain. The receiver meets a sensitivity of -110 dBm at 60 mA in a 1.4V digital CMOS process
In vivo Investigation on the Fluoride Content in and on Human Enamel after Topical Applications (1983)

In this in vivo study the amount of fluoride present on and in human enamel was followed longitudinally for a period of 3 months. The fluoridating agents were an APF gel and the fluoridating lacquers Duraphat and Fluor Protector. The fluoride on the enamel (Fon, mainly as CaF2) was determined by the Caslavska method. The fluoride in the enamel (F2) was measured in five enamel layers removed by acid etching. 12 patients wore the treated enamel specimens and controls for periods of 1, 4 and 12 weeks before the Fon and F2 determinations were made. The CaF2 (or Fon) was lost in vivo in all three treatments at a rate of about 20 μg cm-2 in the first week. Consequently, APF gel- and Duraphat-treated specimens lost nearly all CaF2 in vivo in this period. The amount of CaF2 present in the Fluor Protector case was noticeable up to 1 month. A second conclusion from this study is that the amount of acquired F- (F2 in a layer of 30 μm) following APF gel or Duraphat treatment was negligible after 1 week in vivo. A Fluor Protector treatment introduced an amount of acquired fluoride of 11, 14 and 15 μg cm-2 after 1 4 or 12 weeks, respectively. This study shows that if sufficient CaF2 is deposited on the enamel in vivo for a sufficiently long time, the amount of F∼ in the enamel can be increased significantly. Thirdly, despite the fact that during the in vivo experiments considerable amounts of CaF2 were lost in the saliva, no measurable enrichment of control sound enamel resulted, not even in sound enamel specimens 3 mm from the treated blocks.
A Three-dimensional Interactive Virtual Dissection Model to Simulate Transpetrous Surgical Avenues (2003)

The ability to visualize and understand anatomic spatial relationships is crucial in surgical planning, as is a surgeon's confidence in performing the surgery. The virtual reality simulator does not replace the need for practicing surgery on cadavers. However, it is designed to facilitate, via stereoscopic projection, learning how to manipulate a drill in complicated or unfamiliar surgical approaches (e.g., a transpetrosal approach).
Stress relaxation and cartilage shaping under laser radiation (1996)

The problem of a purposeful change of the shape of cartilage is of great importance for otolaryngology, orthopaedics, and plastic surgery. In 1992 we have found a possibility of controlled shaping of cartilage under moderate laser heating. This paper presents new results in studies of that phenomenon. We have measured temperature and stress in a tissue undergoing to irradiation with a Holmium laser. Study of cartilage structure allowed us to find conditions for laser shaping without pronounced alterations in the structure of matrix.
Transport Properties in Carbon Nanotubes films for Hydrogen Sensor Applications (2006)

Tumor growth and metastasis are ultimately mechanical processes involving cell migration and uncontrolled division. Using a 3D discrete model of cells, we show that increased compliance as observed for cancer cells causes them to grow at a much faster rate compared to surrounding healthy cells. We also show how changes in intercellular binding influence tumor malignancy and metastatic potential. These findings suggest that changes in the mechanical properties of cancer cells is the proximate cause of uncontrolled division and migration and various biochemical factors drive cancer progression via this mechanism.
Days to Soybean Physiological Maturity (2010)

Discusses the growth and development of soybean plants in relation to day length.
Action of substance P (neurokinin‐1) receptor activation on rat neostriatal projection neurons (1999)

Substance P (SP) acts as a neurotransmitter in the neostriatum through the axon collaterals of spiny projection neurons. However, possible direct or indirect actions of SP on the neostriatal output neurons have not been described. Targets of SP terminals within the neostriatum include interneurons, spiny neurons, afferent fibers and boutons. SP induces the release of both dopamine (DA) and acetylcholine (ACh). Since some postsynaptic actions of both DA and ACh on spiny neurons are known, we asked if activation of neostriatal NK1-class receptors is able to reproduce them. The SP NK1-receptor agonist, GR73632 (1 μM), had both excitatory and inhibitory actions on virtually all spiny neurons tested at resting potential. The excitatory action was blocked by atropine and coursed with an increase in firing rate and input resistance (RN). The inhibitory action was blocked by haloperidol and coursed with a reduction in firing rate and RN. Therefore, the release of both DA and ACh induced by NK1-receptor activation modulates indirectly the excitability of the projection neurons. SP facilitates the actions of these transmitters on the spiny neuron. A residual excitatory response to the NK1-receptor agonist was observed in 30% of a sample of neurons tested in the presence of both haloperidol and atropine. The increase in RN that accompanied this response could be observed in the presence of 1 μM TTX or 100 μM Cd2+, suggesting a direct effect. Double labeling showed that only SP-immunoreactive neurons were facilitated by NK1-receptor activation in these conditions. Synapse 33:26–35, 1999. © 1999 Wiley-Liss, Inc.
Design and optimisation of a microwave reactor for kilo-scale polymer synthesis (2019)

Current industrial production of polymer resins is generally undertaken in large multi-tonne stirred tank reactors. These are characterised by relatively slow heating and cooling cycles, resulting in long vessel cycle times and extended production campaigns. In this work we present a design for a hybrid microwave/oil jacket proof of concept system capable of producing up to 4.1 kg of polymer resin per batch. By exploiting rapid volumetric heating effects of microwave energy at 2.45 GHz, we have optimised the synthetic regime, such that a 3.7 kg batch of polyester resin pre-polymer can be made in only 8 h 20 min, with higher molecular weight (Mn 2100) compared to the conventional process taking 22 h 15 min (Mn 1200), yielding an increase in synthesis rate of at least 265%. The increase in polymer molecular weight also suggests a higher conversion was achieved over a shorter time scale.
Sequential Deposition of NbN/MgO Film on Si(100) Using Pulsed KrF Excimer Laser Deposition Method with Different Ambiences (1996)

Sequential formation of NbN/MgO bilayers on Si(100) using pulsed KrF excimer laser deposition with different ambiences of oxygen and nitrogen has been performed. The effects of nitrogen ambience on the NbN formation in this sequential process are examined. The deposited films are characterized by X-ray ( Cu-Kα) diffraction, X-ray photoelectron spectroscopy and measurement of the critical temperature of superconducting transition. The concentration of nitrogen in the NbN film increases with the ambient pressure up to 9×10 -2 Torr and superconducting transition is observed at ∼12.7 K. However, the plume distribution became broader with increasing N 2 gas pressure and non- negligible oxidation of the NbN films occurred. The reasons for the oxidation problem are related to the enhancement due to the multiple collisions between the ablated particles and oxygen impurity, which is mainly generated by resputtering from the surfaces of both the previously deposited MgO film substrate and its holder.
Synthetic Studies in the <i>Veratrum</i> Alkaloid Series. II. The Total Synthesis of Verarine, Veratramine, Jervine, and Veratrobasine (1975)

Coupling of 3β-acetoxy-5α-etiojerv-12(13)-en-17-one (1) with the lithio derivative of 2-ethyl-5-methylpyridine provides the crucial intermediate (3) for the subsequent elaboration to verarine. Aromatization of 3 to 4 and reduction of the latter provides a mixture from which N-acetyl-5α,6-dihydroverarine (11) was isolated. Subsequent introduction of the 5,6-double bond in the latter and removal of the N-acetate function completed the synthesis of verarine (31). In a similar sequence of reactions employing 1 and the lithio derivative of 2-ethyl-3-methoxy-5-methyl-pyridine, the resultant intermediate (54), was elaborated to 5α,6-dihydroveratramine (56). Due to known conversions of the latter to veratramine (14), jervine (32), veratrobasine (33), and 11-deoxojervine (34), the formal total synthesis of these natural products is complete.
SwiftTuna: Responsive and incremental visual exploration of large-scale multidimensional data (2017)

For interactive exploration of large-scale data, a preprocessing scheme (e.g., data cubes) has often been used to summarize the data and provide low-latency responses. However, such a scheme suffers from a prohibitively large amount of memory footprint as more dimensions are involved in querying, and a strong prerequisite that specific data structures have to be built from the data before querying. In this paper, we present SwiftTuna, a holistic system that streamlines the visual information seeking process on large-scale multidimensional data. SwiftTuna exploits an in-memory computing engine, Apache Spark, to achieve both scalability and performance without building precomputed data structures. We also present a novel interactive visualization technique, tailed charts, to facilitate large-scale multidimensional data exploration. To support responsive querying on large-scale data, SwiftTuna leverages an incremental processing approach, providing immediate low-fidelity responses (i.e., prompt responses) as well as delayed high-fidelity responses (i.e., incremental responses). Our performance evaluation demonstrates that SwiftTuna allows data exploration of a real-world dataset with four billion records while preserving the latency between incremental responses within a few seconds.
International Study of the Prevalence and Outcomes of Infection in Intensive Care Units (2009)

Infections are common in patients in contemporary ICUs, and risk of infection increases with duration of ICU stay. In this large cohort, infection was independently associated with an increased risk of hospital death.
Minimal Detectable Change of the Timed “Up & Go” Test and the Dynamic Gait Index in People With Parkinson Disease (2010)

The results showed that the TUG and the DGI have generally acceptable random measurement error and test-retest reliability. These findings should help clinicians and researchers determine whether a change in an individual patient with PD is a true change.
Bioeconomics of Spiny Lobster Farming in Indonesia (2012)

Spiny lobster puerulus settlements have recently been found in bays in Lombok, Indonesia, leading to the development of lobster grow-out culture in adjacent areas. This research suggests that lobster farming in Indonesia is a viable alternative livelihood for Indonesian fishers. Currently, returns to investment are modest and largely dependent on the price and availability of lobster seed and credit. Farmers are harvesting the lobsters as soon as they reach marketable size (100 grams) to minimize potential mortality and generate income as soon as possible. This research suggests there are significant benefits from delaying harvest until the lobsters are larger (approximately 300 grams) to benefit from higher yields. The profitability of the industry is not expected to be significantly impacted by large increases in fuel prices, although a disease epidemic would be devastating. Feeds are dominantly low-value finfish, the majority of which is caught by the farmer. There are significant economic benefits to be realized from the use of pelleted diets (especially if they are functional feeds) and farmers indicated that they would be willing to try them if they were available. Early adoption of pellets by this nascent industry is likely to prevent significant negative environmental impacts as the industry develops.
A new lithium-rich anti-spinel in Li–O–Br system (2015)

In spinel-type materials currently known, the divalent anions are arranged in a closed-pack lattice and cations of various valences occupy some or all of the tetrahedral and octahedral sites. We report here the first discovery of an "electronically inverted" anti-spinel. The new material, crystallized in a defect spinel structure, was obtained from the dehydration of Li5Br(OH)4 under moderate pressure and temperature conditions.
Correlation of Six-Minute Walking Performance with Quality of Life is Domain- and Gender-Specific in Healthy Older Adults (2015)

We analyzed the relationship between performance on the 6-min walk test (6MWT) and health-related quality of life (HRQoL) in older subjects. Our secondary aim was to determine the distance to be completed on the 6MWT for the subject to achieve a score of 50 on the Short Form (36) Health Survey (SF-36). Associations were tested using linear correlation and multivariate linear regression. Participants were 130 healthy older individuals. The predictive performance of the 6MWT based on an SF-36 score of 50 was assessed using a receiver operating characteristic curve and its area under curve (AUC). Associations were observed between physical functioning, role-emotional, social functioning, vitality, general health score, and 6MWT performance in women, after adjusting for confounding variables (coefficients: 0.57, 0.38, 0.40, and 0.46, respectively; p < 0.05). No association was found for men. The distance for the 6MWT to predict an SF-36 score of 50 was 481 m for men in the physical functioning (AUC: 0.79) and role-physical (AUC: 0.84) domains, and 420 m for women in role-emotional (AUC: 0.75), role-physical (AUC: 0.80), and general health (AUC: 0.80) domains. Our results indicate that superior 6MWT performance may be associated with better HRQoL in several domains in only healthy older women. No association between 6MWT performance and role-emotional, mental health, or vitality domains was found. We suggest that a score of 50 is represented by a 6MWT distance of 481 m for men and 420 m for women, at least in the role-physical domain.
Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca <sup>2+</sup> -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells (2013)

I-1 and sarco/endoplasmic reticulum Ca2+ -ATPase synergistically induce the vascular smooth muscle cell contractile phenotype. Gene transfer of constitutively active I-1 is a promising therapeutic strategy for preventing vascular proliferative disorders.