gebhart/patrepeval huggingface dataset:
Le rôle de la protéine adénovirale de capside VI dans la modulation du cycle cellulaire (2014)

Les Adénovirus humains sont des virus non enveloppés se répliquant dans le noyau des cellules hôtes.Durant l’infection et après leur entrée par endocytose, les Adénovirus sont transportés au noyau pourinitier l’expression du génome viral. Dans l’endosome, les capsides virales subissent un désassemblagepartiel et libèrent le facteur viral lytique, la protéine VI (pVI). Au niveau de la membrane de l’endosome,cette protéine va alors induire sa rupture permettant ainsi le relargage des virions au sein du cytoplasmegrâce à son hélice amphipatique N-terminale. Par la suite, pVI est transportée vers des structuresnucléaires appelées PML nuclear bodies (PML-NB), associée une ubiquitine ligase cytoplasmique, laNedd4.2. Les PML-NB sont des complexes nucléaires multi-protéiques qui ont des propriétésantivirales. Celles-ci impliquent le recrutement de facteurs de transcription répressifs comme parexemple la protéine anti apoptotique Daxx ou encore le suppresseur de tumeur p53, impliqué dans larégulation du cycle cellulaire. Il a été montré que la protéine pVI en complexe avec Nedd4.2 induit larelocalisation de Daxx des PML-NB dans le cytoplasme, ce qui permet une expression efficace dugénome viral. Ainsi, l’inhibition fonctionnelle de Daxx par pVI suggère que cette protéine virale puisseaussi être impliquée dans la restriction de p53.Dans cette étude, nous avons montré que le nombre des modifications post-traductionnelles (PTM) dep53 augmentent en présence de pVI dans la cellule. De plus, les données obtenues montrent quel’expression de pVI affecte la transcription dépendante de p53 et que l’interaction avec Nedd4.2 n’estpas nécessaire pour inhiber les fonctions de p53. Pour étudier l’implication de pVI dans la modulationdu cycle cellulaire, nous avons créé une lignée cellulaire humaine exprimant cette protéine virale defaçon stable. La caractérisation de cette lignée a permis de mettre en évidence une prolifération cellulaireaccrue. Nos observations ont aussi montré une perte importante des PML-NB et une réduction desprotéines clés du cycle cellulaire p53 et pRb, un autre suppresseur de tumeur. Par des techniques demicro-injection et l’utilisation de l’inhibiteur MG132, nous avons observé que ces deux facteurscellulaires sont ciblés vers le protéasome et dégradés lors de la surexpression de pVI. L’étude desfonctions de cette protéine virale laisse penser que la protéine pVI présente un potentiel oncogéniquecar en effet, sa surexpression induit la dérégulation de l’homéostasie cellulaire et l’inhibition desuppresseurs de tumeur, comme p53 et pRb.
1-Phenylpiperidine-2,4,6-trione (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Phenylpiperidine-2,4,6-trioneJohn D. MeeCite this: J. Org. Chem. 1975, 40, 14, 2135–2136Publication Date (Print):July 1, 1975Publication History Published online1 May 2002Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/jo00902a031https://doi.org/10.1021/jo00902a031research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A fully digital permanent magnet synchronous motor drive with flux weakening (1991)

Permanent magnet synchronous motors (PMSM) are salient when designed with buried or interior magnets. Salient pole PMSM have shown better torque capability by utilising the reluctance torque, and may have a large flux weakening region when compared to the more common non-salient pole PMSM. A new approach for flux weakening in PMSM drives is presented, and a fast digital vector modulator with look-up tables is described. The control principles are verified by simulations and laboratory tests on a 2.8 kW salient pole PMSM drive.
Abscission of Cotton Floral Buds and Bolls as Influenced by Factors Affecting Photosynthesis and Respiration<sup>1</sup> (1974)

The effects of some environmental factors on abscission (shedding) of young cotton ( Gossypium hirsutum L.) fruits were investigated because excessive shedding is sometimes a problem in cotton production. Increasing the concentration of CO 2 in the atmosphere from 350 to 1,000 ppm decreased shedding, increased the glucose and fructose contents of leaves, and lowered the average node number of the first bolls. Increasing the daily photoperiod from 8 to about 14 hours had similar effects. Conversely, shedding was increased by warm nights (30 C) and by low light intensity. These results indicate that factors that decrease photosynthesis or increase respiration may delay fruiting and decrease retention of floral buds (squares) and bolls. Low light intensity could become critical with high plant populations (more than 100,000 plants/ha), cloudy weather, rank growth, or a combination of the above conditions.
RS-61443—A NEW, POTENT IMMUNOSUPPRESSIVE AGENT (1991)

The immunosuppressive activity of RS-61443, a semisynthetic derivative of mycophenolic acid, was examined in 33 canine renal allografts. Initial studies established that triple therapy consisting of 20 mg/kg RS-61443 in combination with 5 mg/kg cyclosporine and 0.1 mg/kg methylprednisolone was the optimal combination to prevent graft rejection. The median survival time was 8.1 +/- 1.2 days in dogs without treatment (n = 5), 8.5 +/- 1.7 days in the treatment control group (CsA 5 mg/kg, MP 0.1 mg/kg; n = 6), 36.0 +/- 9.6 days with RS-61443 monotherapy (40 mg/kg; n = 6); and 122.4 +/- 38.75 days with triple therapy (n = 16). Graft prolongation was statistically significant when compared with controls (P less than 0.05 and 0.002, respectively). Six recipients in the triple therapy group survived over 150 days without major adverse effects. Long-term administration of RS-61443 (20 mg/kg/day) did not cause nephrotoxicity, hematotoxicity, or hepatotoxicity, with the exception of a slight elevation of the alkaline phosphatase levels. Gastrointestinal symptoms including gastritis, diarrhea, and anorexia were common, especially under 40 mg/kg RS-61443 monotherapy, and appeared to be dose-related. Despite its immunosuppressive activity, an increased susceptibility to bacterial or viral infections was not observed. Histological studies of the kidney grafts revealed slight interstitial cell infiltration without vascular or glomerular damage.
APD performance in light sharing PET applications (2005)

An APD-based, light-sharing detector has been evaluated for use in PET. The detector configuration is a 2 /spl times/ 2 array of 5 mm /spl times/ 5 mm Hamamatsu S8664-55 APDs used to readout multi-crystal LSO blocks. Initially, a basic performance study was undertaken with a single APD coupled to a chemically etched 4 mm /spl times/ 4 mm /spl times/ 10 mm LSO crystal (teflon wrapped) using a custom, single-channel fast ASIC preamplifier. Timing and energy resolution measurements with a /sup 22/Na source were performed using the monolithic LSO crystal coupled to the APD. The timing resolution of the APD channel in coincidence with a plastic scintillator coupled to a PMT was 870 ps FWHM. The energy resolution of the 511 keV photopeak was 12.1% FWHM. Based on these initial results, a 9 /spl times/ 9 array of 2 mm /spl times/ 2 mm /spl times/ 20 mm LSO crystals was assembled and evaluated with a 2 /spl times/ 2 APD array. The LSO block had an average energy resolution of 20.9% and a timing resolution of 2.47 ns FWHM. These results show that APDs are promising photodetectors for high-resolution and cost-effective PET systems utilizing light-sharing block detectors.
<i>In vitro</i> Inhibition of Food Spoilage and Foodborne Pathogenic Bacteria by Essential Oil and Leaf Extracts of <i>Magnolia liliflora</i> Desr. (2008)

The aim of this study was to examine the chemical composition of the essential oil isolated from the floral parts of Magnolia liliflora Desr. by hydrodistillation, and to test the efficacy of essential oil and various leaf extracts against a diverse range of microorganisms comprising food spoilage and foodborne pathogenic bacteria. The chemical composition of essential oil was analyzed by GC-MS. It was determined that 52 compounds, which represented 78.07% of total oil, were present in the oil. The oil contained mainly levoxine (15.59%), methylcyclopropane (24.26%), 2-beta-pinene (5.3%), caryophyllene oxide (4.01%), and beta-caryophyllene (1.7%). The oil (1000 ppm/disc) and leaf extracts (1500 ppm/disc) exhibited promising antibacterial effects against the tested pathogens as a diameter of zones of inhibition (9 to 18 and 7 to 12 mm) and MIC values (125 to 1000 and 500 to 3000 microg/mL), respectively. Also, the oil had a potent detrimental effect on the viable count of the tested bacteria. The results obtained in this study support the role of essential oil and the leaf extracts derived from M. liliflora as a remarkable approach to inhibit the growth of food spoilage and foodborne pathogens.
Mechanism of protection of transepithelial barrier function by<i>Lactobacillus salivarius</i>: strain dependence and attenuation by bacteriocin production (2012)

Enhanced barrier function is one mechanism whereby commensals and probiotic bacteria limit translocation of foreign antigens or pathogens in the gut. However, barrier protection is not exhibited by all probiotic or commensals and the strain-specific molecules involved remain to be clarified. We evaluated the effects of 33 individual Lactobacillus salivarius strains on the hydrogen peroxide (H(2)O(2))-induced barrier impairment in human epithelial Caco-2 cells. These strains showed markedly different effects on H(2)O(2)-induced reduction in transepithelial resistance (TER). The effective strains such as UCC118 and CCUG38008 attenuated H(2)O(2)-induced disassembly and relocalization of tight junction proteins, but the ineffective strain AH43324 did not. Strains UCC118 and CCUG38008 induced phosphorylation of extracellular signal-regulated kinase (ERK) in Caco-2 cells, and the ERK inhibitor U0126 attenuated the barrier-protecting effect of these strains. In contrast, the AH43324 strain induced phosphorylation of Akt and p38, which was associated with an absence of a protective effect. Global transcriptome analysis of UCC118 and AH43324 revealed that some genes in a bacteriocin gene cluster were upregulated in AH43324 under TER assay conditions. A bacteriocin-negative UCC118 mutant displayed significantly greater suppressive effect on H(2)O(2)-induced reduction in TER compared with wild-type UCC118. The wild-type strain augmented H(2)O(2)-induced phosphorylation of Akt and p38, whereas a bacteriocin-negative UCC118 mutant did not. These observations indicate that L. salivarius strains are widely divergent in their capacity for barrier protection, and this is underpinned by differences in the activation of intracellular signaling pathways. Furthermore, bacteriocin production appears to have an attenuating influence on lactobacillus-mediated barrier protection.
Effect of Mycoplasma on Interferon Production and Interferon Assay in Cell Cultures (1966)

Armstrong, D. (The Children's Hospital of Philadelphia, Philadelphia, Pa.), and K. Paucker. Effect of mycoplasma on interferon production and interferon assay in cell cultures. J. Bacteriol. 92:97-101. 1966.-The influence of mycoplasma on the production and action of interferon was studied in cultures of both L and human embryonic kidney (HEK) cells. Mycoplasma hominis 1, the Negroni agent, and the F12 mycoplasma were used for infection of L cells, and M. hominis 1 and M. pneumoniae for inoculation of HEK cells. All strains were capable of multiplication in the culture systems employed. None produced detectable levels of interferon, and responsiveness of the cells to induction of interferon by virus remained unaltered. Infection with mycoplasma did not impair the sensitivity of the cells to the action of interferon, nor was the replication of vesicular stomatitis virus noticeably diminished.
Tetradymites as Natural Hyperbolic Materials for the Near-Infrared to Visible (2014)

Hyperbolic media exhibit unparalleld properties, e.g, as light absorbers in photovoltaics and photonics, as superlenses in far-field imaging, as subwavelength light concentrators in nanolithography, or as novel materials in emission engineering. With the advent of optical metamaterials, deliberate design of material properties became possible. However, inadvertent variability in fabrication techniques and other factors limit performance characteristics of man-made hyperbolic materials. Here, we draw attention to a class of natural hyperbolic materials, the tetradymites. From generalized spectroscopic ellipsometry we extract the dielectric tensor components and find hyperbolic behavior in Bi2Se3 and Bi2Te3 in the near-infrared to visible spectrum. Previously, natural hyperbolic media were known only in the far-infrared spectral range. As possible applications of tetradymites we discuss superlenses for near-field microscopy and far-field isoindex filters. Solid solutions of tetradymites are likely tunable in operational wavelength from the infrared to the visible, complementing hyperbolic metamaterials.
Steady-State Analysis of the Series Resistance-Inductance Circuit with Controlled Switches (1976)

The effect of forced-commutation on the ac phase controller with a series resistance-inductance load has been investigated. It has been shown that the total circuit power factor can exceed that of the load to sinusoidal current, with selected firing angles. Two modes of switching are introduced in which one maintains the fundamental power factor to near unity despite the load being largely inductive. In the second the fundamental power factor is kept to its most leading value and a relative improvement in distortion factor is achieved.
SoK: Deep Packer Inspection: A Longitudinal Study of the Complexity of Run-Time Packers (2015)

Run-time packers are often used by malware-writers to obfuscate their code and hinder static analysis. The packer problem has been widely studied, and several solutions have been proposed in order to generically unpack protected binaries. Nevertheless, these solutions commonly rely on a number of assumptions that may not necessarily reflect the reality of the packers used in the wild. Moreover, previous solutions fail to provide useful information about the structure of the packer or its complexity. In this paper, we describe a framework for packer analysis and we propose a taxonomy to measure the runtime complexity of packers. We evaluated our dynamic analysis system on two datasets, composed of both off-the-shelf packers and custom packed binaries. Based on the results of our experiments, we present several statistics about the packers complexity and their evolution over time.
The Machinery of Government and Policy-Making (1987)

Who ran the colonial empire? Constitutionally it was the Secretary of State for the Colonies who was answerable to Cabinet in the first instance and ultimately to Parliament. But, however impressive the political authority or departmental ability enjoyed by some Colonial Secretaries, in the examination of imperial policy it is necessary to probe beyond his office and consider inter-departmental relations within Whitehall, the internal organization of the Colonial Office and relations between London and colonial governments. The Colonial Secretary had always had the dual task of upholding HMG’s policy in the colonies and protecting colonial interests from excessive metropolitan demands. Between the wars the Colonial Office was able to operate with minimal contact with other departments; only Palestine, Kenya and the West Indies were sources of occasional embarrassment to the Secretary of State in Cabinet or Parliament. During the 1940s, however, tension between British and colonial interests became more pronounced and there was a corresponding growth in inter-departmental consultation at both official and ministerial levels.
Learning your identity and disease from research papers (2009)

Genome-wide association studies (GWAS) aim at discovering the association between genetic variations, particularly single-nucleotide polymorphism (SNP), and common diseases, which is well recognized to be one of the most important and active areas in biomedical research. Also renowned is the privacy implication of such studies, which has been brought into the limelight by the recent attack proposed by Homer et al. Homer's attack demonstrates that it is possible to identify a GWAS participant from the allele frequencies of a large number of SNPs. Such a threat, unfortunately, was found in our research to be significantly understated. In this paper, we show that individuals can actually be identified from even a relatively small set of statistics, as those routinely published in GWAS papers. We present two attacks. The first one extends Homer's attack with a much more powerful test statistic, based on the correlations among different SNPs described by coefficient of determination (r2). This attack can determine the presence of an individual from the statistics related to a couple of hundred SNPs. The second attack can lead to complete disclosure of hundreds of participants' SNPs, through analyzing the information derived from published statistics. We also found that those attacks can succeed even when the precisions of the statistics are low and part of data is missing. We evaluated our attacks on the real human genomes and concluded that such threats are completely realistic.
Overgrowth of the indigenous gut microbiome and irritable bowel syndrome (2014)

Culture-independent molecular techniques have demonstrated that the majority of the gut microbiota is uncultivable. Application of these molecular techniques to more accurately identify the indigenous gut microbiome has moved with great pace over recent years, leading to a substantial increase in understanding of gut microbial communities in both health and a number of disorders, including irritable bowel syndrome (IBS). Use of culture-independent molecular techniques already employed to characterise faecal and, to a lesser extent, colonic mucosal microbial populations in IBS, without reliance on insensitive, traditional microbiological culture techniques, has the potential to more accurately determine microbial composition in the small intestine of patients with this disorder, at least that occurring proximally and within reach of sampling. Current data concerning culture-based and culture-independent analyses of the small intestinal microbiome in IBS are considered here.
Pd-catalyzed allylic substitution for construction of quaternary stereocenters (2019)

Des del primer treball inicial de Tsuji i Trost, hi ha hagut un ràpid progrés durant les últimes dècades en el desenvolupament de lligands quirals i l'abast de reacció dels electròfils i nucleòfils aplicables en reaccions de substitució al·lílica catalitzades per Pd. A més, s'han utilitzat reaccions de substitució al·lílica asimètriques asimètriques catalitzades per Pd en la síntesi total d'una varietat de molècules quirals complexes, proporcionant una evidència sòlida de la utilitat de la metodologia AAA en el control tant de la regio com de l'enantio-selectivitats. Malgrat els nombrosos avenços ja realitzats, forjar derivats al·lílics ramificats quirals de materials inicials senzills i fàcilment disponibles continua essent una tasca important en la química sintètica, a causa del potencial d’aquests compostos al·lílics quirals en campanyes postintèntiques. Les bastides al·líliques que porten estereocentrisme quaternari basades en reaccions de substitució al·lílica catalitzades per Pd encara no es troben en cap cas. en aquesta tesi, hem desenvolupat una metodologia eficient i concisa per a la síntesi d’amines al·líliques aral a-a-desubstituïdes amb alts nivells de regio i enantioselectivitat. A continuació, vam desbloquejar l’origen de la regio- i l’enantioselectivitat en la inusual aminació al·lílica mitjançant càlculs de la teoria funcional de densitat (DFT) en combinació amb experiments de control mecanicista. Finalment, es van dissenyar lligams quirials nous i eficients i el seu ús en la síntesi en regio- i enantioselectiva de catalitzats de Pd de sulfones al·líliques ramificades. La utilitat del mètode es demostrarà més mitjançant la síntesi del sesquiterpè (-) - Agelasidine A.
Spin transfer induced coherent microwave emission with large power from nanoscale MgO tunnel junctions (2008)

In low resistance-area product MgO magnetic tunnel junction nanopillars, we observe high integrated power (up to 43nW), narrow linewidth (down to 10MHz), spin transfer induced microwave emission at frequencies up to 14GHz due to precession of the free layer magnetization at room temperature. Although all devices were fabricated on the same wafer, they present bimodal transport and precessional characteristics. The devices in which the narrowest linewidths were observed exhibited low resistance and tunneling magnetoresistance (30%), while maintaining large integrated power.
Fusion of fuzzy, NN, GA to the intelligent robotics (2002)

Recently, fuzzy system is used in many fields and places. In order to apply the system to various fields, the tuning and optimizing method of the fuzzy system is the key issue. Some self-tuning methods have been proposed so far. However, these conventional self-tuning methods do not have sufficient capability of learning. In this paper, we propose a new unsupervised/supervised self-tuning fuzzy system, which consists of some membership function expressed by the radial basis function with insensitive region. Teaming is carried out by the genetic algorithms. The descent method is also utilized for tuning the shapes of membership function and consequent parts in the case of supervised learning. The effectiveness of the proposed methods is shown by some numerical examples and simulations.