gebhart/patrepeval huggingface dataset:
Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11). (1995)

Rearrangements of the MLL (Mixed Lineage Leukemia) gene in the human 11q23 cytogenetic locus have been detected in secondary (therapy-related) acute leukemias in patients who have received topoisomerase II inhibitors for prior, independent neoplasms. The topoisomerase II inhibitors implicated in MLL/11q23 secondary leukemias all inhibit the religation step of reaction catalyzed by topoisomerase II. This results in the stabilization of a 'cleavable complex' with double-strand DNA breaks at the point of topoisomerase II binding. This raises the possibility that the cleavable complex participates in the translocation process in MLL/11q23 secondary leukemias. Here we report that the MLL/11q23 breakpoints in 13/13 patients with secondary leukemia map to the same breakpoint cluster region (bcr) noted in de novo MLL/11q23 acute leukemias and the presence of in vivo topoisomerase II inhibitor-induced cleavage sites in MLL/11q23 bcr. We have also cloned and sequenced the breakpoint from a MLL/11q23 secondary acute leukemia. This analysis revealed sequences similar to the consensus sequence for vertebrate topoisomerase II binding and cleavage close to the 11q23 and 4q21 breakpoints. These results support a role for topoisomerase II in mechanism generating translocations in MLL/11q23 secondary acute leukemia.
[P4–573]: A PHASE 2 MULTICENTER, RANDOMIZED, PLACEBO‐CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF EDONERPIC (T‐817) IN PATIENTS WITH MILD TO MODERATE ALZHEIMER's DISEASE (2017)

Edonerpic (T-817; 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate, Toyama Chemical, Ltd) protects against Aβ42-induced neurotoxicity and memory deficits, promotes cortical and hippocampal neuron outgrowth, and preserves hippocampal synapses and spatial memory in tau transgenic mice, possibly via sigma receptor activation. The primary objective was to assess the efficacy and safety of T-817 in Alzheimer's disease (NCT 02079909). Outpatients, ages 55 to 85, meeting criteria for probable AD, MMSE 12–22, taking stable doses of donepezil or rivastigmine, taking or not memantine, were randomly assigned (1:1:1) to placebo, 224mg, or 448mg of T-817 once/day for 52 weeks. The primary outcomes were the ADAScog and ADCS-CGIC (CIBIC+) at week 52. Secondary outcomes were the MMSE, ADCS-ADL, FAQ, and NPI at week 52; and the outcomes at weeks 12, 24, 36, and 44. Biomarkers were MRI whole brain, lateral ventricular, and hippocampal volumes; and CSF Aβ40, 42, t-tau, and p-tau; and population pharmacokinetics. 140 of 158 (88.6%) participants assigned to placebo, 117 of 166 (70.5%) to 224mg, and 120 of 158 (75.9%) to 448mg completed the trial, conducted from June 2014 to December 2016 at 52 US sites. LS mean ADAScog change was 7.9, 7.5, and 7.1 for the placebo, 224mg, and 448mg groups, respectively; difference, placebo vs. 448mg, -0.8 (95% CI: -2.8, 1.1; P=0.3919). Mean ADCS-CGIC scores were 5.2, 5.2, and 5.3; difference, 0.04 (95% CI: -0.19, 0.26; P=0.7588). There were no significant differences for the secondary outcomes. P-tau was nominally significantly lower in the 448mg group vs. placebo (n=24 and N=18, P=0.0338). Hippocampal volumes decreased less in the 224mg group than placebo (n=79 and N=89; -0.27 vs. -0.39 mL, P=0.0106) but not in the 448mg group (n=76; -0.31 vs. -0.39 mL, P=0.0996). 4.4%, 13.9% and 14.6% discontinued because of AEs, placebo, 224mg, and 448mg groups, respectively. Most frequent AEs ≥ 5%: diarrhea (12.7%, 20.5%, 31.0%), nausea (3.8%, 7.8%, 5.7%); infections, injuries, falls, agitation and anxiety were more common with placebo. T-817 appeared safe, tolerable, with expected GI symptoms occurring early, but without evidence for clinical effect in the protocol-specified primary and secondary outcomes. Decreased CSF p-tau and hippocampal volumes require confirmation.
Modulation of cisplatin sensitivity and accumulation by amphotericin B in cisplatin-resistant human lung cancer cell lines. (1993)

To ascertain whether resistance to cis-diamminedichloroplatinum(II) (cisplatin) could be overcome, we determined the effects of amphotericin B (AmB), an antifungal agent, on cisplatin cytotoxicity, cisplatin-induced DNA interstrand cross-links formation, and cellular accumulation of cisplatin in human lung cancer cell lines, PC-9, PC-14, PC-7, and H69 and their corresponding respective cisplatin-resistant sublines PC-9/CDDP, PC-14/CDDP, PC-7/CDDP, and H69/CDDP in vitro. In PC-9/CDDP but not PC-9 cells, augmentation of cytotoxicity was observed when a nontoxic concentration (10 micrograms/ml) of AmB was combined with cisplatin, cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II), and cis-diammine(glycolato)platinum(II). Sensitizing effects of AmB of varying magnitudes on cisplatin cytotoxicity also were observed in all the other cell lines except PC-14. AmB-induced increases in cisplatin-induced interstrand cross-links formation were observed, the magnitudes of which corresponded to the magnitudes of AmB-augmented cisplatin cytotoxicity. Increased intracellular cisplatin accumulation was observed in the presence of AmB in all the cells that were sensitized to cisplatin by AmB. Therefore, the increases in cisplatin accumulation were considered to be responsible, at least in part, for the mechanism of the sensitizing effect. Further experiments using other human lung cancer cell lines showed that cells that were more resistant to cisplatin were more sensitized to cisplatin by AmB than cells that were cisplatin-sensitive.
Ablation of Systemic Phosphate‐Regulating Gene Fibroblast Growth Factor 23 (<i>Fgf23</i>) Compromises the Dentoalveolar Complex (2010)

Fibroblast growth factor-23 (FGF23) is a hormone that modulates circulating phosphate (P(i)) levels by controlling P(i) reabsorption from the kidneys. When FGF23 levels are deficient, as in tumoral calcinosis patients, hyperphosphatemia ensues. We show here in a murine model that Fgf23 ablation disrupted morphology and protein expression within the dentoalveolar complex. Ectopic matrix formation in pulp chambers, odontoblast layer disruption, narrowing of periodontal ligament space, and alteration of cementum structure were observed in histological and electron microscopy sections. Because serum P(i) levels are dramatically elevated in Fgf23(-/-), we assayed for apoptosis and expression of members from the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family, both of which are sensitive to elevated P(i) in vitro. Unlike X-linked hypophosphatemic (Hyp) and wild-type (WT) specimens, numerous apoptotic osteocytes and osteoblasts were detected in Fgf23(-/-) specimens. Further, in comparison to Hyp and WT samples, decreased bone sialoprotein and elevated dentin matrix protein-1 protein levels were observed in cementum of Fgf23(-/-) mice. Additional dentin-associated proteins, such as dentin sialoprotein and dentin phosphoprotein, exhibited altered localization in both Fgf23(-/-) and Hyp samples. Based on these results, we propose that FGF23 and (P(i)) homeostasis play a significant role in maintenance of the dentoalveolar complex.
Exploring personal broadcast channels for rich media sharing in close relationships (2008)

Building on the Internet (IP) platforms available on mobile devices and personal computers (PCs), we implemented a service called weConnect that facilitates broadcast of content via dedicated and personal media channels. weConnect includes simple tools for integrating content into media 'mixes' and provides 'content viewers' for ubiquitous access to weConnect channels via mobile, desktop, and other IP enabled devices. In this paper we present an exploratory user study based on deployment of the weConnect service among individuals in close relationships. The study focuses on the user perception and experience with the 'always-on' channels, delivering personalized content. We started with images, text, and animations as familiar and easily accessible media. We observed a high level of reciprocity in creating and exchanging expressive content and a need for persistence, reuse, and notification of content delivery. The users voiced their enthusiasm for receiving personalized media across mobile and desktop devices. The always-on nature of the weConnect channels raised new requirements for the service design to assist content producers with creating streams of personalized media efficiently and to enable recipients to view the content flexibly.
Reconfigurable interlocking furniture (2017)

Reconfigurable assemblies consist of a common set of parts that can be assembled into different forms for use in different situations. Designing these assemblies is a complex problem, since it requires a compatible decomposition of shapes with correspondence across forms, and a planning of well-matched joints to connect parts in each form. This paper presents computational methods as tools to assist the design and construction of reconfigurable assemblies, typically for furniture. There are three key contributions in this work. First, we present the compatible decomposition as a weakly-constrained dissection problem, and derive its solution based on a dynamic bipartite graph to construct parts across multiple forms; particularly, we optimize the parts reuse and preserve the geometric semantics. Second, we develop a joint connection graph to model the solution space of reconfigurable assemblies with part and joint compatibility across different forms. Third, we formulate the backward interlocking and multi-key interlocking models, with which we iteratively plan the joints consistently over multiple forms. We show the applicability of our approach by constructing reconfigurable furniture of various complexities, extend it with recursive connections to generate extensible and hierarchical structures, and fabricate a number of results using 3D printing, 2D laser cutting, and woodworking.
DESIGN OF A WIDE-ANGLE BICONICAL ANTENNA FOR WIDEBAND COMMUNICATIONS (2009)

The wide-angle bicone antenna terminated by a spherical cap is investigated. The antenna radiation patterns have been observed for various values of ka where k represents the phase constant and a represents the conical length. It is seen that for large values of ka the radiation pattern is limited within an angular sector bounded by the cones of the antenna. Next the antenna is optimized for ultra- wideband (UWB) operation through the use of loading techniques. The transient wideband radiated and received responses of the antenna have been observed and the relationship between the wave shapes of the transient fleld and the input pulse have been determined.
Interpolating and approximating implicit surfaces from polygon soup (2004)

This paper describes a method for building interpolating or approximating implicit surfaces from polygonal data. The user can choose to generate a surface that exactly interpolates the polygons, or a surface that approximates the input by smoothing away features smaller than some user-specified size. The implicit functions are represented using a moving least-squares formulation with constraints integrated over the polygons. The paper also presents an improved method for enforcing normal constraints and an iterative procedure for ensuring that the implicit surface tightly encloses the input vertices.
4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease† (2010)

4SC-101 is a novel immunosuppressive drug with excellent potential for the treatment of intestinal inflammation.
Cri du Chat syndrome (2006)

The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics, and severe psychomotor and mental retardation. Malformations, although not very frequent, may be present: cardiac, neurological and renal abnormalities, preauricular tags, syndactyly, hypospadias, and cryptorchidism. Molecular cytogenetic analysis has allowed a cytogenetic and phenotypic map of 5p to be defined, even if results from the studies reported up to now are not completely in agreement. Genotype-phenotype correlation studies showed a clinical and cytogenetic variability. The identification of phenotypic subsets associated with a specific size and type of deletion is of diagnostic and prognostic relevance. Specific growth and psychomotor development charts have been established. Two genes, Semaphorin F (SEMAF) and delta-catenin (CTNND2), which have been mapped to the "critical regions", are potentially involved in cerebral development and their deletion may be associated with mental retardation in CdCS patients. Deletion of the telomerase reverse transcriptase (hTERT) gene, localised to 5p15.33, could contribute to the phenotypic changes in CdCS. The critical regions were recently refined by using array comparative genomic hybridisation. The cat-like cry critical region was further narrowed using quantitative polymerase chain reaction (PCR) and three candidate genes were characterised in this region. The diagnosis is based on typical clinical manifestations. Karyotype analysis and, in doubtful cases, FISH analysis will confirm the diagnosis. There is no specific therapy for CdCS but early rehabilitative and educational interventions improve the prognosis and considerable progress has been made in the social adjustment of CdCS patients.
Problèmes théoriques de l'enseignement des langues vivantes (1975)

Sumpf Joseph, Koskas Éliane. Problèmes théoriques de l'enseignement des langues vivantes. In: Langages, 9ᵉ année, n°39, 1975. Linguistique et pédagogie des langues, sous la direction de Éliane Koskas et Jean-René Ladmiral. pp. 19-30.
Some Pyrimidine Derivatives<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Pyrimidine Derivatives1Joseph L. Rabinowitz and Samuel GurinCite this: J. Am. Chem. Soc. 1953, 75, 22, 5758–5759Publication Date (Print):November 1, 1953Publication History Published online1 May 2002Published inissue 1 November 1953https://pubs.acs.org/doi/10.1021/ja01118a525https://doi.org/10.1021/ja01118a525research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Perception and Control Strategies for Autonomous Docking for Electric Freight Vehicles (2016)

International audience
Algorithms for density and composition-discrimination imaging for fourth-generation CT systems (1999)

This paper shows that if the off-beam idle detectors in the detection ring of a fourth-generation x-ray computed tomography (CT) system are used to measure the scattered radiation, it is numerically feasible to reconstruct electron-density images to supplement the conventional attenuation-coefficient images of transmitted radiation. It is also shown that by combining these two images, composition changes can be detected with the aid of an effective-atomic-number indicator. The required image-reconstruction algorithms are developed and tested against Monte Carlo simulated measurements, for a variety of phantom configurations. In spite of the relatively poor statistical quality of scattering measurements, it is demonstrated that electron-density images of reasonable quality can be obtained. In addition, it is shown that composition discrimination is possible for materials of effective atomic number greater than five, in the photon energy range of a typical medical x-ray CT system operating at 102 kVp. The obtained supplementary electron-density and composition images can be useful in radiotherapy planning and for studying tumour histology, as well as in industrial and security applications where identification of materials based on density and composition is important.
Spatial Color-to-Grayscale Transform Preserving Chrominance Edge Information (2004)

A color image sent to a monochrome output device must undergo a color-to-grayscale transformation. Such a transform typically retains the luminance channel or a derivative thereof. A problem with this approach is that the distinction between two different colors of similar luminance is lost. This loss can be particularly objectionable if the two colors are spatially adjacent. The paper describes a color-to-grayscale transformation technique that locally preserves distinction between adjacent colors by introducing high-frequency chrominance information into the luminance channel. This is accomplished by applying a spatial high-pass filter to the chrominance channels, weighting the output with a luminance-dependent term; and adding the result to the luminance channel. The outcome of this is that luminance variations are introduced into the image only in those regions containing high-frequency chrominance information. Regions with smoothly varying chrominance undergo little enhancement, and in particular, grayscale input is passed through without alteration. The spatially adaptive nature of the algorithm readily distinguishes it from standard approaches that apply global or pixelwise transformations. Also, preference experiments demonstrate the superior qualitative performance of the proposed approach over standard techniques.
Nonlinear filtering approach to 3-D gray-scale image interpolation (1996)

Three-dimensional (3-D) images are now common in radiology. A 3-D image is formed by stacking a contiguous sequence of two-dimensional cross-sectional images, or slices. Typically, the spacing between known slices is greater than the spacing between known points on a slice. Many visualization and image-analysis tasks, however, require the 3-D image to have equal sample spacing in all directions. To meet this requirement, one applies an interpolation technique to the known 3-D image to generate a new uniformly sampled 3-D image. The authors propose a nonlinear-filter-based approach to gray-scale interpolation of 3-D images. The method, referred to as column-fitting interpolation, is reminiscent of the maximum-homogeneity filter used for image enhancement. The authors also draw upon the paradigm of relaxation labeling to devise an improved column-fitting interpolator. Both methods are typically more effective than traditional gray-scale interpolation techniques.
Autoimmune Lymphoproliferative Syndrome with Somatic<i>Fas</i>Mutations (2004)

Somatic heterozygous mutations of Fas can cause a sporadic form of ALPS by allowing lymphoid precursors to resist the normal process of cell death.
Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome (2014)

Background. Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function after liver transplantation. Murine mortality following 85% hepatectomy can be reduced by the use of soluble receptor for advanced glycation end products (sRAGE) to scavenge damage-associated molecular patterns and prevent their engagement with membrane-bound RAGE. Aims. To explore serum levels of sRAGE, high-mobility group box-1 (HMGB1) protein, and other soluble inflammatory mediators in a fatal case of SFSS. Methods. Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC). Results. HMGB1 levels were markedly higher in the SFSS patient (92.1 ng/mL) compared with the ALF patients (median (IQR) 11.4 (3.7-14.8) ng/mL) and HC (1.42 (1.38-1.56) ng/mL). In contrast, sRAGE levels were lower in the SFSS patient (1.88 ng/mL) compared with the ALF patients (3.53 (2.66-12.37) ng/mL) and were similar to HC levels (1.40 (1.23-1.89) ng/mL). Conclusion. These results suggest an imbalance between pro- and anti-inflammatory innate immune pathways in SFSS. Modulation of the HMGB1-RAGE axis may represent a future therapeutic avenue in this condition.
Synthesis of Unnatural Amino Acids (2003)

This chapter contains sections titled: Introduction Scope of Enamide Substrates Preparation of Enamides Mechanism Ligand Synthesis Other Substrates Summary
Circuit partitioning for logic synthesis (1991)

The authors introduce a circuit partitioning method based on analysis of reconvergent fan-out. A corolla is defined as a set of overlapping reconvergent fan-out regions. The authors partition the circuit into a set of disjoint corollas and use the corollas to resynthesize the circuit. The authors develop the notion of resynthesis potential of a logic circuit and use it to select corollas that resynthesize with most gain. It is shown that resynthesis of large benchmark circuits using the corollas consistently reduces transistor pairs and layout area while improving delay and testability. The use of don't cares to further minimize the corollas in the local context and the global context is explored.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Human Cytomegalovirus US28 Protein Is Located in Endocytic Vesicles and Undergoes Constitutive Endocytosis and Recycling (2001)

Genes encoding chemokine receptor-like proteins have been found in herpes and poxviruses and implicated in viral pathogenesis. Here we describe the cellular distribution and trafficking of a human cytomegalovirus (HCMV) chemokine receptor encoded by the US28 gene, after transient and stable expression in transfected HeLa and Cos cells. Immunofluorescence staining indicated that this viral protein accumulated intracellularly in vesicular structures in the perinuclear region of the cell and showed overlap with markers for endocytic organelles. By immunogold electron microscopy US28 was seen mostly to localize to multivesicular endosomes. A minor portion of the protein (at most 20%) was also expressed at the cell surface. Antibody-feeding experiments indicated that cell surface US28 undergoes constitutive ligand-independent endocytosis. Biochemical analysis with the use of iodinated ligands showed that US28 was rapidly internalized. The high-affinity ligand of US28, the CX(3)C-chemokine fractalkine, reduced the steady-state levels of US28 at the cell surface, apparently by inhibiting the recycling of internalized receptor. Endocytosis and cycling of HCMV US28 could play a role in the sequestration of host chemokines, thereby modulating antiviral immune responses. In addition, the distribution of US28 mainly on endosomal membranes may allow it to be incorporated into the viral envelope during HCMV assembly.