gebhart/patrepeval huggingface dataset:
Rexinoids Isolated from <i>Sophora tonkinensis</i> with a Gene Expression Profile Distinct from the Synthetic Rexinoid Bexarotene (2014)

The retinoid X receptor (RXR) plays a critical role in transcriptional regulation via formation of an RXR homodimer or heterodimers with partner nuclear receptors. Despite the numerous beneficial effects, only a limited number of naturally occurring RXR agonists are known. In this report, two prenylated flavanones (1 and 2) isolated from Sophora tonkinensis were identified as new rexinoids that preferentially activated RXRs, relative to the retinoic acid receptor. The activities of 1 and 2 were the most potent among naturally occurring rexinoids, yet 2 orders of magnitude lower than the synthetic rexinoid bexarotene. Compounds 1 and 2 activated particular RXR heterodimers in a manner similar to bexarotene. A microarray assay followed by quantitative real-time polymerase chain reaction analyses on RNAs isolated from C2C12 myotubes treated with 1 or 2 demonstrated that they significantly increased mRNA levels of lipoprotein lipase, angiopoietin-like protein 4, and heme oxygenase-1. In contrast, bexarotene preferentially potentiated transcription of genes involved in lipogenesis and lipid metabolism such as sterol regulatory element-binding protein-1, fatty acid synthase, and apolipoprotein D by a liver X receptor agonist. In this study, we have demonstrated that two newly identified naturally occurring rexinoids, 1 and 2, possess properties different from bexarotene.
C1q/TNF-related Protein 4 (CTRP4) Is a Unique Secreted Protein with Two Tandem C1q Domains That Functions in the Hypothalamus to Modulate Food Intake and Body Weight (2013)

CTRP4 is a unique member of the C1q family, possessing two tandem globular C1q domains. Its physiological function is poorly defined. Here, we show that CTRP4 is an evolutionarily conserved, ∼34-kDa secretory protein expressed in the brain. In human, mouse, and zebrafish brain, CTRP4 expression begins early in development and is widespread in the central nervous system. Neurons, but not astrocytes, express and secrete CTRP4, and secreted proteins form higher-order oligomeric complexes. CTRP4 is also produced by peripheral tissues and circulates in blood. Its serum levels are increased in leptin-deficient obese (ob/ob) mice. Functional studies suggest that CTRP4 acts centrally to modulate energy metabolism. Refeeding following an overnight fast induced the expression of CTRP4 in the hypothalamus. Central administration of recombinant protein suppressed food intake and altered the whole-body energy balance in both chow-fed and high-fat diet-fed mice. Suppression of food intake by CTRP4 is correlated with a decreased expression of orexigenic neuropeptide (Npy and Agrp) genes in the hypothalamus. These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.
Isatuximab Plus Pomalidomide/Dexamethasone Versus Pomalidomide/Dexamethasone in Relapsed/Refractory Multiple Myeloma: Icaria Phase Iii Study Design (2017)

Treatment for relapsed/refractory multiple myeloma (RRMM) remains an unmet need. Isatuximab, an anti-CD38 monoclonal antibody has shown efficacy and tolerability as a monotherapy and combination therapy in Phase I/II studies in RRMM. Here, we describe the design of the Phase III ICARIA-MM study (NCT02990338) which will evaluate isatuximab in combination with pomalidomide (Pom) and low-dose dexamethasone (dex) (Pom/dex) versus Pom/dex alone in RRMM. Patients will be randomized in a 1:1 ratio. The primary endpoint is progression-free survival. Response will be determined by an independent response review committee using IMWG criteria (2016) and safety will be assessed throughout. Approximately 300 patients (150 in each arm) are expected to enroll. The first patient was recruited in January 2017 and accrual is ongoing.
Performance prediction of large parallel applications using parallel simulations (1999)

Accurate simulation of large parallel applications can be facilitated with the use of direct execution and parallel discrete event simulation. This paper describes the use of COMPASS, a direct execution-driven, parallel simulator for performance prediction of programs that include both communication and I/O intensive applications. The simulator has been used to predict the performance of such applications on both distributed memory machines like the IBM SP and shared-memory machines like the SGI Origin 2000. The paper illustrates the usefulness of COMPASS as a versatile performance prediction tool. We use both real-world applications and synthetic benchmarks to study application scalability, sensitivity to communication latency, and the interplay between factors like communication pattern and parallel file system caching on application performance. We also show that the simulator is accurate in its predictions and that it is also efficient in its ability to use parallel simulation to reduce its own execution time which, in some cases, has yielded a nearlinear speedup.
STUDIES ON ATP DEAMINASE (1967)

The distribution of deaminases active for adenosine compounds was studied and it was found that besides two kinds of deaminases, i.e., non-specific ATP and adenosine deaminases, another acid-type ADP-deaminating enzyme was present in Aspergillus species.Deaminases from Aspergillus glaucus and A. repens were purified and it was confirmed that they were of the same type of non-specific ATP deaminase which was found in Microsporum audouini by the authors.Non-specific acid ADP-deaminating enzymes were found and purified from the koji cultures of both A. ochraceus and A. melleus. They deaminate ADP, ATP, adenosine sulfate, adenosine tetraphoshate, 5′-AMP, dAMP, 3′, 5′-cyclic AMP, adenosine, and 3′-AMP in this order. The optimum pH of ADP-deaminating enzyme obtained from both strains were 3.4 in acetate buffer, and the Km values of A. ochraceus and A. melleus were calculated to be 4.0×10-5M and 6.6×10-5M, respectively.
Expert system of the control programs design of adaptive robots (2002)

To increase efficiency and reliability of technological robots it is necessary to have adaptive control systems. An outline is presented of an expert system specifically designed to automate the design of algorithms and programs for adaptive control of adaptive robots. The basic elements of the expert system are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Real-Time Light Scattering Tracking of Gold Nanoparticles- bioconjugated Respiratory Syncytial Virus Infecting HEp-2 Cells (2014)

Real-time tracking of virus invasion is crucial for understanding viral infection mechanism, which, however, needs simple and efficient labeling chemistry with improved signal-to-noise ratio. For that purpose, herein we investigated the invasion dynamics of respiratory syncytial virus (RSV) through dark-field microscopic imaging (iDFM) technique by using Au nanoparticles (AuNPs) as light scattering labels. RSV, a ubiquitous, non-segmented, pleiomorphic and negative-sense RNA virus, is an important human pathogen in infants, the elderly, and the immunocompromised. In order to label the enveloped virus of paramyxoviridae family, an efficient streptavidin (SA)-biotin binding chemistry was employed, wherein AuNPs and RSV particles modified with SA and biotin, respectively, allowing the AuNP-modified RSVs to maintain their virulence without affecting the native activities of RSV, making the long dynamic visualization successful for the RSV infections into human epidermis larynx carcinoma cells.
Research on Trajectory Planning Algorithm of Unmanned Aerial Vehicle Based on Improved A* Algorithm (2017)

In the research of UAVs'trajectory planning algorithm, the path of unmanned aerial vehicles should be calculated according to the known information of terrain, physiognomy, obstacle, threatening, and etc, as well as flight capability of itself before executing mission and accomplish the mission by tracking the path. An improved A * algorithm combined with the performance and mission of unmanned aerial vehicle (UAV) is proposed, and the algorithm is applied to solve the problem of avoiding threat of UAVs in known dangerous environment, a method of trajectory planning algorithm of unmanned aerial vehicle was studied at the condition of considering comprehensively influence factors of route cost and threat cost. A numerical simulation in reference route planning of UAV s demonstrates the correctness and effectiveness of the improved A* algorithm.
El Profesor Bang (1932)

La muerte del Profesor Bernhard Bang, ocurrida en Copenhague, es motivo de justo pesar para los amantes de la ciencia, y de manera especial para los medicos veterinarios. Nacio el ilustre Profesor el 7 de junio de 1848. Terminados sus estudios de medicina humana, se entrego con entusiasmo creciente a los de medicina veterinaria. Ganado el titulo de Doctor en Medicina Veterinaria ingreso como Profesor de Cirugia animal y de Anatomia patologica a la famosa Escuela de Conpenhague. Por varios anos dicto esas catedras, asi como tambien la de Anatomia, pero — avido de perfeccionar sus conocimientos  quiso ampliar sus estudios en las Facultades veterinarias de Berlin, Dresden, Munich, Stuuttgard, Paris y Viena.
HgCdTe position sensitive detector (PSD) development (2010)

Oceanit Laboratories Inc. is collaborating with Raytheon Vision Systems (RVS) to develop a novel HgCdTe-based position sensitive detector (PSD) that can ultimately be implemented in target detection and tracking or target interception applications in the infrared spectral region.
A Structural Design Automation Environment for Digital Systems. (1977)

This paper describes a design automation system for digital systems that promotes a structured design approach both in logic design phase and in the physical implementation phase. (Author)
Simple model for the design of polymeric piezoelectric ultrasonic transducers (1993)

An electrical equivalent circuit model for piezoelectric transducers, incorporating mechanical and dielectric losses of polymeric sensor materials has been used to analyze the performance of broadband ultrasonic transducers in the time and frequency domains. The model provides a close agreement between the simulated and experimentally observed dynamic responses of the piezoelectric transducers which were designed and fabricated with ferroelectric polymer sensor materials and an epoxy-tungsten composite as a backing material. >
Antimicrobial Effect of Ozonated Water on Bacteria Invading Dentinal Tubules (2004)

Ozone is known to act as a strong antimicrobial agent against bacteria, fungi, and viruses. In the present study, we examined the effect of ozonated water against Enterococcus faecalis and Streptcoccus mutans infections in vitro in bovine dentin. After irrigation with ozonated water, the viability of E. faecalis and S. mutans invading dentinal tubules significantly decreased. Notably, when the specimen was irrigated with sonication, ozonated water had nearly the same antimicrobial activity as 2.5% sodium hypochlorite (NaOCl). We also compared the cytotoxicity against L-929 mouse fibroblasts between ozonated water and NaOCl. The metabolic activity of fibroblasts was high when the cells were treated with ozonated water, whereas that of fibroblasts significantly decreased when the cells were treated with 2.5% NaOCl. These results suggest that ozonated water application may be useful for endodontic therapy.
Grouping ID based device trigger mechanism for 3GPP MTC communications (2014)

Third Generation Partnership Project (3GPP) proposed the Machine Type Communication (MTC) communications technology for machines or devices to communicate with each other without human intervention. The characteristics of MTC communications are different from that of conventional Human-to-Human (H2H) communications. The execution of an MTC device is task-based and triggered by the MTC application server. In most of scenarios, the time period for an MTC to perform a task is short. The number of MTC devices is expected to be several magnitudes higher than the number of H2H communication device. In MTC communications networks, an MTC device is addressed by its Mobile Subscriber ISDNs (MSISDNs) that is also used to address the H2H devices. Due to that huge number of MTC devices may coexist in the network, it is a challenge that the number of MSISDNs may insufficient to support both MTC communications and H2H communications. In this paper, we propose a grouping ID based device trigger mechanism for 3GPP MTC communications to resolve the issue “insufficient number of MSISDN.” Simulation experiments are conducted to investigate the performances of the mechanism.
Exploiting multiuser diversity for medium access control in wireless networks (2003)

Multiuser diversity refers to a type of diversity present across different users in a fading environment. This diversity can be exploited by scheduling transmissions so that users transmit when their channel conditions are favorable. Using such an approach leads to a system capacity that increases with the number of users. However, such scheduling requires centralized control. In this paper, we consider a decentralized medium access control (MAC) protocol, where each user only has knowledge of its own channel gain. We consider a variation of the ALOHA protocol, channel-aware ALOHA; using this protocol we show that users can still exploit multiuser diversity gains. First we consider a backlogged model, where each user always has packets to send. In this case we show that the total system throughput increases at the same rate as in a system with a centralized scheduler. Asymptotically, the fraction of throughput lost due to the random access protocol is shown to be 1/e. We also consider a splitting algorithm, where the splitting sequence depends on the users' channel gains; this algorithm is shown to approach the throughput of an optimal centralized scheme. Next we consider a system with an infinite user population and random arrivals. In this case, it is proved that a variation of channel-aware ALOHA is stable for any total arrival rate in a memoryless channel, given that users can estimate the backlog. Extensions for channels with memory are also discussed.
A watt-level 2.4 GHz RF I/Q power DAC transmitter with integrated mixed-domain FIR filtering of quantization noise in 65 nm CMOS (2014)

This paper presents an S-band RF I/Q power DAC transmitter with embedded mixed-domain finite-impulse-response (FIR) filter to suppress out-of-band (OOB) quantization noise for FDD/co-existence. Watt-level output power and low output OOB noise level is achieved through (1) power combining (2) device stacking with thick oxide devices in a switching-class power amplifier (PA) and (3) embedded RF FIR filtering. To combat the strong conductance-to-amplitude/phase nonlinearity of switching-class digital PAs, a transformer-based FIR architecture is proposed that ensures completion of filtering after the nonlinearity. Implemented in 65 nm CMOS, the transmitter has a measured peak output power of 29.1 dBm with 42% system efficiency at 2.25 GHz. The measured noise floor at 100 MHz offset from the 2.4 GHz carrier is -134 dBc/Hz for a 20 MHz 64-QAM signal at 200 MSa/s including 8 dB noise floor suppression from transformer-based two-tap third-order FIR filtering, yielding an ENOB of 8.18.
Education in the History of Medicine, ed. by John B. Blake, New York and London, Hafner, 1968, pp. 132. $7.50. (1971)

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Transforming a hospital facility company into an integrated medical care organization. (1994)

This article outlines the steps a major integrated health delivery system in Chicago has undertaken to transition from a primarily hospital-based fee-for-service organization to an integrated medical care organization operating under full-risk capitation. The focus is on vision setting, building a foundation for change, structural building blocks, network building steps, and lessons learned to date.
A bandpass ΣΔ modulator with 92 dB SNR and center frequency continuously programmable from 0 to 70 MHz (2002)

Use of a bandpass /spl Sigma//spl Delta/ modulator permits direct conversion of an analog signal to digital form at IF frequencies. This allows the ADC to be moved closer to the receiver front end. Moving the digital interface closer to the antenna reduces receiver analog circuit complexity, eliminates DC-offset cancellation, inphase/quadrature (I/Q) gain calibration, dual I/Q mixers and improves system robustness as mixing is in the digital domain. This second-order bandpass /spl Sigma//spl Delta/ modulator is targeted for an airborne radar system but is also expected to find use in a variety of communications applications. Measurements yield signal to noise+distortion ratio (SNR) from 92 dB (15 b) in narrowband ( 366 kHz) to 44 dB (7 b) in broadband (62.6 MHz) about a center frequency of 55.5 MHz. Modulator sampling rate is 4 GHz and it is implemented in AlInAs-InGaAs HBT technology. The performance represents an improvement of approximately a factor of 10 in bandwidth, resolution and center frequency over other reported bandpass modulators.
The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers. (2017)

LBA2501 Background: Larotrectinib is the first selective small-molecule pan-TRK inhibitor. TRK fusions appear oncogenic independent of tumor lineage, are widely distributed across cancers, and affect all ages. We present an integrated dataset from 3 studies intended to support regulatory approval. Methods: All NTRK fusion pts with RECIST measurable disease enrolled to the adult (NCT02122913, n=8) and pediatric (NCT02637687, n=12) phase I trials and adult/adolescent phase 2 trial (NCT02576431, n=35) were analyzed. TRK fusion status was determined by local testing prior to enrollment. Pts were dosed predominantly at 100mg BID on a continuous 28-day schedule. Primary objective was investigator-assessed overall response rate (ORR) per RECIST v1.1. Secondary endpoints included duration of response (DOR) and safety. Data were cut on 31-JAN-2017. Results: 55 TRK fusion pts (12 peds, 43 adult, range: 4 mo.-76 yrs) were enrolled (median priors=2). Fusions involved NTRK1 (n=25), NTRK2 (n=1), and NTRK3 (n=29), and 14 unique partners. 13 discrete tumor types were treated: salivary (12), sarcoma (10), infantile fibrosarcoma (7), lung (5), thyroid (5), colon (4), melanoma (4), cholangio (2), GIST (2), and other (4). For the 46 pts evaluated to date, the ORR was 78% (95% CI: 64%–89%) with responses in 12 unique tumor types. Responses are ongoing in 29/33 (88%) pts, excluding 3 peds pts whose DOR was censored at attempted curative resection. A median DOR has not been reached as the majority of responders remain on treatment without progression. The longest responder remains on treatment at 23 mos., 8 pts remain in response at >12 mos., and 16 pts at >6 mos. NTRK solvent front mutations were detected in all 4 pts to develop acquired resistance. The most common TEAEs were fatigue (30%), dizziness (28%), and nausea (28%). 5 (11%) pts required dose reductions. Conclusions: Larotrectinib has demonstrated consistent and durable antitumor activity in TRK fusion cancers, across a wide range of ages and tumor types, and was well-tolerated. Larotrectinib could be the first targeted therapy developed in a tissue type-agnostic manner, and the first developed simultaneously in adults and pediatrics. Clinical trial information: NCT02576431, NCT02122913, NCT02637687.
IgE to Cross-Reactive Carbohydrate Determinants: Analysis of the Distribution and Appraisal of the in vivo and in vitro Reactivity (2002)

<i>Background:</i> IgE to cross-reacting carbohydrate determinants has already been described by several authors, but their function and distribution are still a matter of debate. In previous studies we showed how the presence of IgE to bromelain could be a useful and simple marker of the presence of IgE to carbohydrate epitopes. <i>Methods:</i> A survey of 1,831 subjects with a suspected allergic respiratory disease has been carried out by detecting IgE to bromelain. Data were analysed on the basis of demographical and allergological parameters. To find out whether a glycoprotein is capable of triggering an allergic reaction, 1,076 subjects were also skin tested with several purified molecules bearing carbohydrate side chains differing in number, composition and complexity. <i>Results:</i> An overall prevalence of 23% of positive IgE to cross-reacting carbohydrate determinants was recorded. Prevalence varied when subsets of non-allergic (5%), non-pollen-allergic (10%), and pollen-allergic (31%) subjects were considered. Prevalence further increased in subsets with multiple pollen sensitization (71%), and with a previous pollen immunotherapy course (46%), whereas minor differences were found in gender and age distribution. Almost all the allergenic extracts recorded negative in the skin test gave a positive IgE test in vitro. A higher correlation was found mainly with plant-derived allergenic extracts, whereas a lower one was recorded with mites and fungi. Horseradish peroxidase was the only glycoprotein capable of exerting a positive skin test in 21% of the subjects with IgE to cross-reacting carbohydrate determinants, 80% of them having IgE to the HRP molecule. <i>Conclusions:</i> IgE to cross-reacting carbohydrate determinants are common among the allergic population and the binding to skin test negative allergenic extracts further confirms their poor biological activity. Further studies on horseradish peroxidase should be carried out to define the role of the glycan side chains in its allergenic activity.
CD4 antigen-based antireceptor peptides inhibit infectivity of human immunodeficiency virus in vitro at multiple stages of the viral life cycle. (1989)

Benzylated derivatives of peptides corresponding to residues 81 through 92 of the CD4 molecule [CD4-(81-92)] inhibit human immunodeficiency virus 1 (HIV-1)-induced cell fusion and infection in vitro. If such peptides are to be considered as candidates in the therapy of HIV infection, it is crucial to know if the anti-HIV efficacy of CD4-based peptides is limited to blockade of infection and virus-induced cell fusion or if other stages of the viral life cycle are affected by these compounds. Accordingly, an in vitro quantitative microassay for acute HIV infection was divided into two kinetic phases corresponding to the two general stages of the viral life cycle: (i) viral infection and (ii) transmission of virus and viral protein products through cell contact or release of free virions. CEM-SS cell cultures were treated with peptide during either the infection or the transmission phase of the assay. When peptides were present during the infection phase, inhibition of syncytium formation correlated with decreased expression of viral core protein p24 and lack of infectious cell centers when cells exposed to virus were washed and replated onto fresh uninfected indicator cells. These data are consistent with complete inhibition of viral infection when peptide is present only during initial exposure to virus. Unexpectedly, parallel inhibition of syncytium formation, decreased p24 levels, and inhibition of infectious cell center formation were also seen even when peptides were added as late as 48 hr after inoculation, during the transmission period of the assay. Since viral binding and penetration are completed well before 48 hr in this assay system, CD4-(81-92) peptide derivatives appear to exert a virostatic effect on cultures already infected with HIV-1, decreasing p24 production, cytopathicity, and cell-mediated infectivity.