gebhart/patrepeval huggingface dataset:
Five new alkaloids from the tropical ascidian, Lissoclinum sp. lissoclinotoxin A is chiral (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFive new alkaloids from the tropical ascidian, Lissoclinum sp. lissoclinotoxin A is chiralPhilip A. Searle and Tadeusz F. MolinskiCite this: J. Org. Chem. 1994, 59, 22, 6600–6605Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/jo00101a018https://doi.org/10.1021/jo00101a018research-articleACS PublicationsRequest reuse permissionsArticle Views552Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
N9841: A randomized phase III equivalence trial of irinotecan (CPT-11) versus oxaliplatin/5-fluorouracil (5FU)/leucovorin (FOLFOX4) in patients (pts) with advanced colorectal cancer (CRC) previously treated with 5FU (2005)

3506 Background: Single agent CPT-11 is indicated as standard treatment (Rx) for pts with CRC who failed prior 5FU based Rx. FOLFOX4 is active as 1st and 2nd line Rx of CRC. The primary goal of this trial was to determine whether overall survival (OS) of pts treated with 2nd line CPT-11 (Arm A) was equivalent to Rx with 2nd line FOLFOX4 (Arm B). Pts were to cross-over to the other Rx after 2nd line failure. Methods: Eligible pts had failed one prior 5FU based Rx, either for metastatic disease or ≤ 6 months of adjuvant 5FU Rx. Initial protocol Rx (doses in mg/m2) for Arm A: CPT-11 350 d1 q3w (300 for ECOG performance status = 2, age ≥ 70, or prior pelvic radiation) and Arm B: OXAL 85 d1 + LV 200/5FU 400 bolus + 600 as a 22 hour infusion d1, 2 q2w. Final analysis was scheduled after 405 deaths to have 82% power to detect non-equivalence at a hazard ratio of 1.25. Results: 491 pts were randomized to Rx between 10/99 to12/03 (245-A, 246-B). 289 pts (59%) failed previous 5FU for metastatic CRC. 82% of pts have died. 220 pts (45%) received protocol mandated 3rd line therapy (A-57%, B-43%). Efficacy results (including OS, time to progression (TTP), and response rate (RR)) and common grade 3+ toxicities on initial Rx are shown in the table below. 16 pts died < 60 days of study entry (A-5%, B-2%, p = 0.12). 2nd line Rx with CPT-11 was associated with more grade ≥ 3 nausea, vomiting, diarrhea, and febrile neutropenia; FOLFOX4 had more neutropenia and parasthesias. Conclusions: In pts failing prior 5FU Rx for CRC, OS is not significantly different based on whether 2nd line Rx begins with either CPT-11 or FOLFOX4 (HR=1.04, 95% CI 0.9–1.3). 2nd line Rx with FOLFOX4 produces a higher RR and a trend toward longer TTP. Both arms had notable OS in pts who had failed 1st line 5FU Rx. Supported by NIH Grant CA25224 and Sanofi-Synthelabo. Efficacy & Toxicity (≥ Grade 3), by Initial Rx Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca, Genentech, Lilly Oncology, Pfizer, Sanofi Pfizer, Sanofi Pfiizer, Sanofi Sanofi
Softening Rates of Fermented Cucumber Tissue: Effects of pH, Calcium, and Temperature (1995)

ABSTRACT First‐order softening rates for cucumber mesocarp tissue were determined as a function of pH (2.6–3.8), calcium (0–72 mM), and temperature (25–65°C). Fermented tissue, unlike blanched, nonfermented tissue, often showed two softening rates in first‐order plots. A five–variable, empirical equation was derived (R 2 = 0.913) which predicted softening rates as a tunction of pH, calcium concentration, and temperature. Comparison of softening rates in tissue fermented with and without 18 mM added calcium indicated the softening rate depended upon the concentration of calcium present during the period of measurement and not upon previous history of calcium exposure.
Raman study and lattice dynamics of single molecular layers of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">MoS</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (1991)

A valence-force-field model has been used to study the lattice dynamics of molybdenum disulfide single molecular layers. A comparison between the room-temperature Raman spectra of aqueous suspensions and the calculated phonon-dispersion curves for single layers of ${\mathrm{MoS}}_{2}$ with trigonal prism and octahedral coordination indicates that ${\mathrm{MoS}}_{2}$ single layers adopt a structure in which the Mo atoms are octahedrally coordinated, as opposed to bulk ${\mathrm{MoS}}_{2}$ where the trigonal prism coordination is usually found. Besides the zone-center modes, strong Raman peaks have been observed at 156, 226, and 333 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$. The presence of these peaks is attributed to a zone-folding mechanism resulting from the formation of a 2${\mathit{a}}_{0}$\ifmmode\times\else\texttimes\fi{}${\mathit{a}}_{0}$ superlattice in the single layers of ${\mathrm{MoS}}_{2}$. The superlattice is, in turn, believed to correspond to the basal-plane atomic arrangement of a distorted octahedral structure. Lattice-dynamics calculations based on an octahedrally coordinated structure with a significant metal-metal interaction yield good agreement with the observed frequencies. When the single molecular layers restack and the sulfur-sulfur interaction between the layers is recovered, the layers convert back to the trigonal prismatic configuration of crystalline ${\mathrm{MoS}}_{2}$.
Variable Pulse Mode Driving IR Source Based 3D Robotic Camera (2005)

jongmoo @ skku.edu There has shown a significant interest in a high performance of, at the same time, a compact size and low cost of, 3D sensor, in reflection of a growing need of 3D environmental sensing for service robotics. One of the important requirements associated with such a 3D sensor is that sensing does not irritate or disturb human in any way while working in close and continuous contact with human. Furthermore, such a 3D sensor should be reliable and robust to the change of environmental illumination as service robots are required to work day and night. This paper presents a 3D IR camera with variable pulse mode driving source that is human friendly and robust enough for application to home service robots. IR pulse mode driving method is chosen as the sensing medium in order to meet the requirement of human friendliness and robustness to illumination change. A Digital Mirror Device (DMD)is employed to generate and project variable patterns at a high speed for real-time operation. In this paper, DMD is positioned to reflect IR directly so that efficiency is maximized. In implementation, we emphasize the integration of modular components to support real-time sensing and compactness in size. The experimental results have demonstrated that the implemented 3D IR Camera is robust to illumination change, in addition to its advantage of human friendliness. 1.
Isotype Switching Increases Efficacy of Antibody Protection against<i>Cryptococcus neoformans</i>Infection in Mice (1998)

The isotype and epitope specificities of antibodies both contribute to the efficacy of antibodies that mediate immunity to Cryptococcus neoformans, but the relationship between these properties is only partially understood. In this study, we analyzed the efficacy of protection of two sets of immunoglobulin G (IgG) isotype switch variants from two IgG3 monoclonal antibodies (MAbs) which are either not protective or disease enhancing, depending on the mouse model used. The two IgG3 MAbs 3E5 and 4H3 have different epitope specificities. Protection experiments were done with A/JCr mice infected intravenously with C. neoformans and administered with 3E5 IgG3 and its IgG1, IgG2a, and IgG2b switch variants. These experiments revealed that IgG1, IgG2b, and IgG2a were each more effective than IgG3. For 4H3 IgG3 and its IgG1 and IgG2b switch variants, the relative efficacy was IgG2b > IgG1 >> IgG3. The combination of 3E5 IgG3 and 4H3 IgG3 was more deleterious than either IgG3 alone. All IgG isotypes were opsonic for mouse bronchoalveolar cells, with the relative efficacy being IgG2b > IgG2a > IgG1 > IgG3. These results (i) confirm that a nonprotective IgG3 MAb can be converted to a protective MAb by isotype switching, (ii) indicate that the efficacy of protection of an IgG1 MAb can be increased by isotype switching to another subclass, (iii) show that protective and nonprotective IgG MAbs are opsonic, and (iv) provide additional evidence for the concept that the efficacy of the antibody response to C. neoformans is dependent on the type of MAb elicited.
Screening the Missing Electron: Nanochemistry in Action (2009)

The excitement of nano-test-tube chemistry in a single-walled carbon nanotube is exemplified in our study on electron doping in carbon nanotubes. Electron doping through the 1D van Hove singularity of single-walled carbon nanotubes is realized via a chemical reaction of an encapsulated organocerium compound, CeCp3. The decomposition of CeCp3 inside the carbon nanotubes increases the doping level and greatly enhances the density of conduction electrons. The transition of the cerium encapsulating semiconducting tubes to metallic results in enhanced screening of the photoexcited core hole potential. This fact illustrates the importance of many body effects in understanding core-level excitation process in carbon nanotubes.
Valuable Markers for Contrast-Induced Nephropathy in Patients Undergoing Cardiac Catheterization (2008)

Cystatin C was useful for predicting the occurrence of CIN. Urinary L-FABP was the only marker of transient renotubular damage.
A priority based exploration algorithm for path planning of an unmanned ground vehicle (2014)

Robots plays a vital role and are widely used in surveillance applications where humans cannot reach, due to the associated danger. For such applications, use of Unmanned Ground Vehicle (UGV) is highly demanded by incorporating algorithms for robot localization and path planning. This paper proposes development of a three-wheeled robot using sensors and wireless transmission network and methods to map the unknown environment to a PC through a visual map created using Processing software. The information collected by the robot is to be transmitted wirelessly to a control PC, located far away. A priority based exploration algorithm for path planning to navigate the robot through the unknown even environment avoiding the static obstacles with the help of ultrasonic sensors to reach the destination through the shortest path, is implemented using PIC16F877A microcontroller.
Topic facet modeling (2015)

In this paper, we propose a novel Topic Facet Model (TFM), a probabilistic topic model that assumes all words in single sentence are generated from one topic facet. The model is applied to automatically extract forum posts semantics for uncovering the content latent structures. We further prototype a visual analytics interface to present online discussion forum semantics. We hypothesize that the semantic modeling through analytics on open online discussion forums can help users examine the post content by viewing the summarized topic facets. Our preliminary results demonstrated that TFM can be a promising method to extract topic specificity from conversational and relatively short texts in online programming discussion forums.
Programmed cell death (apoptosis) in pancreatic cancers of hamsters after treatment with analogs of both luteinizing hormone-releasing hormone and somatostatin. (1989)

Female Syrian golden hamsters with N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic cancers were treated with long-acting microcapsular preparations of the 6-D-tryptophan analog of luteinizing hormone-releasing hormone [( D-Trp6]LH-RH), releasing 25 micrograms/day; the somatostatin analog D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160), liberating 15 micrograms/day; and the combination of these two peptides. Therapy with analogs was initiated 24 weeks after initial administration of BOP. These treatments resulted in significantly better survival of all animals as compared to BOP controls; body weights of surviving peptide-treated animals were significantly higher than those of the BOP controls. All 15 BOP-control animals had pancreatic cancers. In the group treated with RC-160 four hamsters were free of tumors, whereas therapy with [D-Trp6]LH-RH resulted in seven tumor-free animals, and combination of RC-160 and [D-Trp6]LH-RH resulted in eight tumor-free animals from groups of 15. Only preblastomatous lesions were found in these animals. Average tumor weight of animals in all peptide-treated groups, sacrificed 60 days after beginning the peptide treatment, was significantly lower than that of BOP controls. No significant differences were seen between the various peptide-treated groups. Histologically, analog-treated tumors of hamsters showed striking regressive changes characteristic of programmed cell death (apoptosis). This apoptosis presumably resulted from hormonal effects on tumor cells from prolonged treatment with these analogs of hypothalamic hormones. Our present data confirm the beneficial effect of long-acting microcapsules of [D-Trp6]LH-RH and RC-160 on pancreatic carcinoma and suggest a mode of action for these peptides. The feasibility of applying this treatment with analogs of hypothalamic hormones to human pancreatic carcinoma can be envisioned from these studies.
Properties of the glycerol acylating enzymes in microsomal preparations from the developing seeds of safflower (<i>Carthamus tinctorius</i>) and turnip rape (<i>Brassica campestris</i>) and their ability to assemble cocoa‐butter type fats (1990)

Abstract Microsomal membrane preparations from the developing seeds of safflower ( Carthamus tinctorius , var. Gila) and turnip‐rape ( Brassica campestris , var. Bele) catalyzed the assembly of triacylglycerols (triglycerides) from sn‐glycerol 3‐phosphate and acyl‐CoA. The membrane preparations were used to assess the acyl specificity properties of the initial acylating enzymes—glycerol 3‐phosphate acyltransferase (GPAT) and 1‐acylglycerol 3‐phosphate acyltransferase (lysophosphatidic acid acyltransferase, LPAAT)—that are responsible for the fatty acids at positions sn‐1 and sn‐2 of the sn‐triacylglycerol, respectively. In spectrophotometric assays it was possible to evaluate, to some extent, how these enzymes will utilize unusual and foreign fatty acids that are not normally found in these particular plant species. The acylating enzymes from both plants used, to varying extents, a comprehensive range of acyl‐CoA donor species and some kinetic properties of the substrates involved are presented. The enzymes from safflower, however, were generally the more selective, whereas the turnip‐rape was less particular and could utilize a range of acyl substrates. The enzymes from both plants hardly utilized erucate (C22∶1), and the significance of this is discussed in terms of mechanisms which have evolved in order to exclude certain, perhaps detrimental, fatty acids from structural membrane lipids and dedicate them to storage lipid assembly. The ability of the microsomal preparations, from the developing seeds of both plants, to synthesize cocoabutter type fats was investigated. Microsomal membranes were incubated with glycerol 3‐phosphate and equimolar amounts of palmitate, oleate and stearate. Safflower preparations catalyzed the construction of sn‐triacylglycerol with largely palmitate, oleate and stearate in positions sn‐1, 2 and 3, respectively. The selectivity for acyl species in rape was less pronounced, however, substantial saturated‐unsaturated‐saturated oils were still produced. The results are discussed in terms of the acyl selectivity properties of the glycerol acylating enzymes. It is evident that given the correct composition of fatty acids, the plant can produce cocoabutter or other exotic fats.
Optical metasurfaces: new generation building blocks for multi-functional optics (2018)

Optical metasurfaces (OMs) have emerged as promising candidates to solve the bottleneck of bulky optical elements. OMs offer a fundamentally new method of light manipulation based on scattering from resonant nanostructures rather than conventional refraction and propagation, thus offering efficient phase, polarization, and emission control. This perspective highlights state of the art OMs and provides a roadmap for future applications, including active generation, manipulation and detection of light for quantum technologies, holography and sensing.
Cyclizations of α-Keto Ester Modified Aspartic Acids in Peptides (2006)

Aspartic acid peptides with α-keto ester modification can cyclize to form γ-lactam derivatives. This reaction represents an easy access to conformationally restricted peptidomimetics.
A facile layer-by-layer assembly method for the fabrication of fluorescent polymer/quantum dot nanocomposite thin films (2014)

We demonstrated an efficient and robust approach for the preparation of polymer/quantum dot (QD) nanocomposite thin films in nonpolar media. By employing photopolymerization based on the thiol-ene reaction, thiol-containing polymer with affinity groups for CdSe@CdS QDs was produced for the buildup of the polymer/CdSe@CdS QD nanocomposite thin films utilizing layer-by-layer assembly. The polymer/QD nanocomposite films were characterized by SEM, TEM, fluorescence spectrometry, thermogravimetric analysis, confocal laser scanning microscopy and time-resolved fluorescence spectrometry. The resulting free-standing polymer/QD nanocomposite films exhibit high fluorescent intensity, moderate transparency, good photostability and thermal stability. We further applied photolithographic patterning in conjunction with an LBL assembly method to fabricate a polymer/CdSe@CdS QD nanocomposite pattern on a flexible substrate. This versatile and facile method provides prospects for the design of novel photonic devices based on the polymer/QD nanocomposite thin films.
Identification of transcripts with enriched expression in the developing and adult pancreas (2008)

Taken together, this work provides evidence that the SAGE libraries generated here are a valuable resource for continuing to elucidate the molecular mechanisms regulating pancreas development. Furthermore, our studies provide a comprehensive analysis of pancreas development, and insights into the regulatory networks driving this process are revealed.
Efficacy and tolerability of a gatifloxacin/prednisolone acetate fixed combination for topical prophylaxis and control of inflammation in phacoemulsification: a 20-day-double-blind comparison to its individual components (2013)

Treatment with the fixed-dose combination of gatifloxacin/prednisolone eye drops was as effective as the non-fixed combination in preventing infection and controlling inflammation after phacoemulsification and intraocular lens implantation.
Ipmicra: Toward a Distributed and Adaptable Location Aware Web Crawler. (2004)

Distributed crawling has shown that it can overcome important limitations of the centralized crawling paradigm. However, the distributed nature of current distributed crawlers is currently not fully utilized. The optimal benefits of this approach are usually limited to the sites hosting the crawler. In this work we propose IPMicra, a distributed location aware web crawler that utilizes an IP address hierarchy and allows crawling of links in a near optimal location aware manner.
Extremely small red-green-blue beam combiners for compact projection-type displays (2014)

Laser beam combiners, which can be used for compact projection-type displays, are reviewed and a newly-proposed extremely-small laser beam combiner composed of optical waveguides and optical couplers is described. Here, the laser beams with three RGB (Red-Green-Blue) primary colors are combined into one single beam by using the laser beam combiner. Such combiners are classified into three categories, i.e., a mirror-prism type, an optical-fiber type and an optical-waveguide type. The mirror-prism-type combiners are composed of the mirrors and/or prisms for combining the laser beams. The optical-fiber-type combiners use the optical couplers made of optical fibers. On the other hand, opticalwaveguide- type combiners, which are based on the optical waveguides, are particularly useful because they enable us to construct extremely small laser combiners integrated with laser sources. Here, we proposed and analyzed a new integrated waveguide-type red-green-blue (RGB) beam combiner that can contribute to a miniaturization of the compact projection-type displays such as an eyewear projector. The essential point of this beam combiner is that it is composed of three individual waveguides for RGB light inputs, and three directional couplers. The combined output light can be obtained from the single waveguide. The waveguide supports the single mode transmission. The efficiency for output light is as high as 96%, and the size is as small as 0.06×7.8 mm. In addition, the small dependence of the output efficiency on the wavelength and the relatively large fabrication tolerance are obtained.
3-D interconnection for ultra-dense multichip modules (1990)

A three-dimensional interconnection technology is described that allows a reduction of the occupied area by a factor of 7 or 8 as against 2-D interconnection. The approach consists of interconnecting the bare chips not in the XY plane, but along the Z-axis. The process entails interconnecting the four lateral areas (sides) of the cube formed by stacking n chips (n=8-10) on top of one another. The chips are individually interconnected on a thin film identical to a TAB (tape automatic bonded) film by means of gold wires, prior to cubing. These chips are standard, off-the-shelf, bump-free devices. After passing electrical testing and burn-in, they are then glued on top of one another with the TAB film. After these n chip+film assemblies have been cured (polymerized), a trim operation is carried out to cut the n-chips cube out of the TAB-film carrier cube. The trim line is approximately 100 mu m from the edge of the chips. The cube containing the n chips thus provides four lateral areas (sides) in which appear the cross sections of the gold wires connecting each lead of each chip to the corresponding leads on the flexible films. These gold wire cross-sections may be interconnected in two different ways according to the number of chip layouts/outputs or the conductor pitch.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>