gebhart/patrepeval huggingface dataset:
Abstract 2: Cortical Bone Stem Cells Derived Exosomes as Potent Modulator of Cardiac Immune Response and Repair After Injury (2016)

Rationale: Cortical bone derived stem cells (CBSCs) are known to have improved growth kinetics and myocardial repair properties that are superior to other known stem cell types used. Salutary effects of CBSCs in large are mediated by paracrine secretion. Since exosomes represent an active component of released factors we tested if CBSC derived exosomes (CBSCs-Exo) can recapitulate the beneficial reparative effects of CBSCs. Objective: Determine CBSCs derived exosomes and their contents for myocardial repair. Methods and Results: Exosomes were isolated from murine CBSCs by ultracentrifugation and had typical size (30-100nm), as validated by electron microscopy and dynamic light scattering. To determine cardiac therapeutic value, CBSCs- Exo (60μg) were injected into the border zone of the mouse heart after myocardial infarction (MI). Animals injected with CBSCs-Exo had reduced infarct size and increased myocyte survival after MI injury. Interestingly, serum levels of pro-inflammatory cytokines were significantly reduced along with decreased expression of CD68+ cells in animals receiving CBSCs-Exo versus control animals. Long term analysis of CBSC-Exo animals showed improved cardiac function and contractility compared to saline treated animals concurrent with enhanced angiogenesis 6 weeks after MI. Salutary effects of CBSC-Exo were confirmed in vitro. CBSCs-Exo increased cardiac protection in NRVMs after hypoxic challenge and enhanced tube formation in HUVECs. Simultaneously, treatment of bone marrow-derived macrophages stimulated with lipopolysaccharide (LPS) and treated with CBSCs-Exo showed increased polarization towards the M2 phenotype, demonstrating an immunomodulatory capacity of CBSCs-Exo. The underlying mechanism for beneficial effects was linked to increased packaging of cardioprotective miRs including miR125, miR20 and miR18a in CBSCs-Exo confirmed by MiRNA array analysis. Conclusion: Exosomes derived from CBSCs provide a cell free system that retains the reparative power of CBSC. CBSCs-Exo augment cardiac function after myocardial injury recapitulating earlier findings with CBSCs. The packaging of cardioprotective and immune-modulatory miRs in CBSCs-Exo appears to enhance their reparative effects after MI.
Magnetic immunoassay with SQUID and magnetic marker (2005)

In this study, a magnetic immunoassay utilizing SQUID and magnetic marker is developed to detect antigen IgE (or IL8). The antigen is detected by using its antibody that is labeled with a magnetic marker made of Fe/sub 3/O/sub 4/ particle with nominal diameter of 25 nm. The particle is coated with polymer, and the antibody is immobilized on the surface of the polymer. Since the marker can keep remanence /spl mu//sub o/M/sub r/ = 49 mT after magnetization, we use the remanent field for the detection of the antigen-antibody binding. A high T/sub c/ directly-coupled SQUID is used to detect the magnetic field from the marker. Since the magnetic field from the marker rapidly decreases with distance, it is important to realize close distance between the cooled SQUID and the room temperature sample. The results show the relationship between the signal flux /spl Phi//sub s/ and the molecular weight of IgE (or IL8) is shown. The horizontal and vertical axes represent the molecular weight and the signal flux /spl Phi//sub s/, respectively. As shown, good relationship between /spl Phi//sub s/ and the molecular weight was obtained. We can detect as small as 2 att-mol of IgE. This result demonstrates the high sensitivity of the present method. Here, it should be noted that the signal flux /spl Phi//sub s/ = 1 m/spl Phi//sub 0/ roughly corresponds to the magnetic field of 10 pT. We also note that the improvement of the sensitivity of the system is possible since the SQUID can detect the signal flux much less than 1 m/spl Phi//sub 0/.
Word Level Symbolic Model Checking A New Approach for Verifying Arithmetic Circuits (2018)

The highly-publicized decision error in the Pentium has emphasized the importance of formal verification of arithmetic operations.
Sequential Analysis of α‐ and β‐Globin Gene Expression During Erythropoietic Differentiation from Primate Embryonic Stem Cells (2006)

The temporal pattern of embryonic, fetal, and adult globin expression in the alpha (zeta --> alpha) and beta (epsilon --> gamma and gamma --> beta) clusters were quantitatively analyzed at the transcriptional and translational levels in erythrocytes induced from primate embryonic stem cells in vitro. When vascular endothelial growth factor receptor-2(high) CD34(+) cells were harvested and reseeded onto OP9 stromal cells, two-wave erythropoiesis occurred sequentially. Immunostaining and real-time reverse transcription-polymerase chain reaction analyses of floating mature erythrocytes revealed that globin switches occurred in parallel with the erythropoietic transition. Colony-forming assays showed replacement of primitive clonogenic progenitor cells with definitive cells during culturing. A decline in embryonic zeta- and epsilon-globin expression at the translational level occurred in individual definitive erythroid progenitors. Expression of beta-globin in individual definitive erythroid progenitors was upregulated in the presence of OP9 stromal cells. Thus, this system reproduces early hematopoietic development in vitro and can serve as a model for analyzing the mechanisms of the globin switch in humans.
DETERMINATION OF PRODUCTION REASONS OF VIBRATION AND NOISE LEVEL SCATTERING OF MASS-PRODUCED INDUCTION MOTORS (1995)

ABSTRACT A considerable variation in noise and vibration data between members of a group of nominally identical mass-produced induction motors has been observed. The paper describes the analysis of production causes of vibration and noise level scattering, common to a small three-phase squirrel-cage motors. The presented method is based on dimensional chains of physical and geometrical quantities. The method is used to determine the contribution of dimensional and other parameters in the vibration and noise level scattering of induction motors A calculation procedure for the vibration velocity and sound-power level has been formulated. The mechanical and magnetic sources without neglecting the effect of stator frame, bearing shields and rotor residual flux harmonics have been considered. Analytical results are compared with experimental statistical results of two groups of nominally identical induction motors and good agreement is obtained. The method should be very useful for the industry for assessing the causes of excessive dispersion of vibration and noise level of mass-produced motors. The method can also be applied to vibration and noise data analysis of newly-designed machines.
Antiandrogenic Effect of Spirolactones: Mechanism of Action (1975)

Spirolactones are aldosterone antagonists which inhibit the binding of aldosteroneto the renal mineralocorticoid receptor. These molecules also possess an antiandrogenic effect which could be due, among other possibilities, to a peripheral antagonism of androgens. This hypothesis has been tested in the present study. From in vivo experiments, spironolactone and K(† canrenoate appear to inhibit the binding of [3H]5αdihydrotestosterone [3H]DHT to the cytosolic and nuclear receptor of the rat ventral prostate. The doses used are in the same range as those used for demonstrating the antimineralocorticoid effect of these molecules. In vitro incubations and in vitro displacement studies show that spironolactone and K† canrenoate are respectively about 20 and 100 times lesseffective than DHT in displacing 50% of 5 × 10-10 M [3H]DHTfrom its receptor. Spirolactones are also able to compete with [3H]DHT for the specific 8 S cytosolic receptor. Neither spironolactone nor K× canrenoate decreases prostatic5α-reductase activity, even at a concentration as high as 10-5M. Itseems likely that spirolactones, besides their action on testosterone biosynthesis, exert theirantiandrogenic activity via a peripheral androgen antagonism. (Endocrinology97: 52, 1975)
Mucoid Pseudomonas aeruginosa (1976)

Two adult patients with cystic fibrosis had late onset of symptoms with principal involvement only of the lungs. The absence of other typical features of cystic fibrosis confused the diagnosis. Recovery of mucoid<i>Pseudomonas aeruginosa</i>from sputum cultures helped to establish the diagnosis in these patients, because these mucoid isolates are rarely obtained from subjects who do not have cystic fibrosis. Recent findings, which have identified the mucoid isolates as predominantly a single strain of<i>P aeruginosa</i>and have documented its widespread carriage in the United States by patients with cystic fibrosis, point to an interesting epidemiologic relationship between this bacterium and this disease. (<i>JAMA</i>236:2190-2192, 1976)
Temporal Creatine Kinase Curves in Acute Myocardial Infarction:<i>Implications of a Good Empiric Fit With the Log-Normal Function</i> (1993)

To maximize the information one can obtain from the temporal curves of creatine kinase (CK) after acute myocardial infarct (AMI), the authors tested how well the curves were fit by three functions: the log-normal function, the gamma function, and the function of Schwerdt and associates (Cardiovasc Res 1990;24:328-334). The log-normal function fit best. Using time course curves of the isoenzyme CK-MB in 16 patients with AMI, the authors found that the integrated area under the fitted log-normal function correlated closely with the postinfarct ejection fraction. Together, the success of the log-normal function and mathematical analysis of the kinetics of CK-time curves impose a form on the release of CK from the heart, and they imply that k, the first-order rate constant of loss of CK from the serum, may be indeterminate from the CK-time curve alone. Although this indeterminancy of k helps explain the prior successes and failures in sizing AMIs from CK-time curves, it should not discourage one from obtaining important quantitative and prognostic information from these CK-time curves. It does suggest that such associations will be largely empiric.
Realization of a ROIC for 72×4 PV-IR detectors (2008)

Silicon Readout Integrated Circuits (ROIC) for HgCdTe Focal Plane Arrays of 1×4 and 72×4 photovoltaic detectors are represented. The analog circuit blocks are completely identical for both, while the digital control circuit is modified to take into account the larger array size. The manufacturing technology is 0.35μm, double poly-Si, three-metal CMOS process. ROIC structure includes four elements TDI functioning with a super sampling rate of 3, bidirectional scanning, dead pixel de-selection, automatic gain adjustment in response to pixel deselection besides programmable four gain setting (up to 2.58pC storage), and programmable integration time. ROIC has four outputs with a dynamic range of 2.8V (from 1.2V to 4V) for an output load of 10pF capacitive in parallel with 1MΩ resistance, and operates at a clock frequency of 5 MHz. The input referred noise is less than 1037 μV with 460 fF integration capacitor, corresponding to 2978 electrons.
Trusted Virtual Infrastructure Bootstrapping for On Demand Services (2012)

As cloud computing continues to gain traction, a great deal of effort is being expended in researching the most effective ways to build and manage secure and trustworthy clouds. Providing consistent security services in on-demand provisioned Cloud infrastructure services is of primary importance due to the multi-tenant and potentially multi-provider nature of Cloud Infrastructure. Cloud security infrastructure should address two aspects of the IaaS operation and dynamic security services provisioning: (1) provide security infrastructure for secure Cloud IaaS operation; (2) provisioning dynamic security services. Although the first task is a traditional task in security engineering, dynamic provisioning of managed security services in virtualized environment remains a problem and requires additional research. Entire frameworks have been proposed and demonstrated but although successful, there is a tendency to see such solutions as integrated 'all in one' infrastructures. This paper describes a light-weight mechanism and protocol for building trust between two machines that takes advantage of the Trusted Platform Module (TPM) to handle a key exchange and remote trusted deployment of a bootstrapping tool (referred to as the Bootstrapping Initiator (BI)). Once deployed, the BI can execute any arbitrary software required which could be (but is not limited to) solutions for advanced architecture management such as the Dynamic Access Control Infrastructure (DACI). The proposed solution provides a light-weight layer of trust backed by a TPM that additional systems can build upon as required by the individual use case without the requirement for a specific management or security infrastructure to be deployed along with it.
2 Gbit/s data transmission from an unfiltered laser-based phosphor-converted white lighting communication system (2015)

We demonstrate data transmission of unfiltered white light generated by direct modulation of a blue gallium nitride (GaN) laser diode (LD) exciting YAG:Ce phosphors. 1.1 GHz of modulation bandwidth was measured without a limitation from the slow 3.8 MHz phosphor response. A high data transmission rate of 2 Gbit/s was achieved without an optical blue-filter using a non-return-to-zero on-off keying (NRZ-OOK) modulation scheme. The measured bit error rate (BER) of 3.50 × 10(-3) was less than the forward error correction (FEC) limit of 3.8 × 10(-3). The generated white light exhibits CIE 1931 chromaticity coordinates of (0.3628, 0.4310) with a color rendering index (CRI) of 58 and a correlated color temperature (CCT) of 4740 K when the LD was operated at 300 mA. The demonstrated laser-based lighting system can be used simultaneously for indoor broadband access and illumination applications with good color stability.
Physicochemical characteristics of electrochemically deposited molybdenum sulfide and polypyrrole-tetrathiomolybdate/molybdenum trisulfide composite electrodes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhysicochemical characteristics of electrochemically deposited molybdenum sulfide and polypyrrole-tetrathiomolybdate/molybdenum trisulfide composite electrodesDaniel Belanger, Guylaine Laperriere, Francois Girard, Daniel Guay, and Gerard TourillonCite this: Chem. Mater. 1993, 5, 6, 861–868Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/cm00030a024https://doi.org/10.1021/cm00030a024research-articleACS PublicationsRequest reuse permissionsArticle Views661Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chimel v. California--Its Effect on Search and Seizure (1972)

b. Consent to the Search."When a householder consents to a warrantless search by the police, he in effect waives his Constitutional rights and cannot later object to the use in court of any incriminating evidence
Donor-acceptor diphenylacetylenes: geometric structure, electronic structure, and second-order nonlinear optical properties (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDonor-acceptor diphenylacetylenes: geometric structure, electronic structure, and second-order nonlinear optical propertiesC. Dehu, F. Meyers, and J. L. BredasCite this: J. Am. Chem. Soc. 1993, 115, 14, 6198–6206Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/ja00067a039https://doi.org/10.1021/ja00067a039research-articleACS PublicationsRequest reuse permissionsArticle Views825Altmetric-Citations229LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abnormal GABA <sub>A</sub> receptors from the human epileptic hippocampal subiculum microtransplanted to <i>Xenopus</i> oocytes (2005)

We studied the properties of GABAA receptors microtransplanted from the human temporal lobe epilepsy (TLE)-associated brain regions to Xenopus oocytes. Cell membranes, isolated from surgically resected brain specimens of drug-resistant TLE patients, were injected into frog oocytes, which rapidly incorporated human GABAA receptors, and any associated proteins, into their surface membrane. The receptors originating from different epileptic brain regions had a similar run-down but an affinity for GABA that was approximately 60% lower for the subiculum receptors than for receptors issuing from the hippocampus proper or the temporal lobe neocortex. Moreover, GABA currents recorded in oocytes injected with membranes from the subiculum had a more depolarized reversal potential compared with the hippocampus proper or neocortex of the same patients. Quantitative RT-PCR analysis was performed of the GABAA receptor alpha1- to alpha5-, beta1- to beta3-, gamma2- to gamma3-, and delta-subunit mRNAs. The levels of expression of the alpha3-, alpha5-, and beta1- to beta3- subunit mRNAs are significantly higher, with the exception of gamma2-subunit whose expression is lower, in subiculum compared with neocortex specimens. Our results suggest that an abnormal GABA-receptor subunit transcription in the TLE subiculum leads to the expression of GABAA receptors with a relatively low affinity. This abnormal behavior of the subiculum GABAA receptors may contribute to epileptogenesis.
Tissue Engineering of Human Biliary Epithelial Cells on Polyglycolic Acid/Polycaprolactone Scaffolds Maintains Long-Term Phenotypic Stability (2003)

The biliary tree is the target of damage in a number of important liver diseases. Although human biliary epithelial cells (hBECs) can be maintained in vitro for up to 8 weeks, using double-collagen gels, which offer a substantial improvement compared with conventional tissue culture plastic, such gels are unstable and, being only semisolid, they do not lend themselves readily to routine analysis. In this study we have investigated the behavior of primary hBECs on polyglycolic acid (PGA) fiber mesh scaffolds. Experiments showed that PGA fiber mesh scaffolds collapsed after 3 or 4 weeks; hence, in order to improve the integrity of the construct, we also developed a polycaprolactone (PCL)-stabilized PGA scaffold. Cells formed spheroidal aggregates while continuing to proliferate long term and expressing phenotypic stability. Aggregates spontaneously detached from the fibers and could either be left to attach to tissue culture plastic, after which cells spread out and continued to proliferate, or they could be reseeded onto fresh constructs, which then became recolonized and the same pattern of tissue formation was repeated. This behavior was observed even after 6 months and is of major significance because this culture model could therefore be used as a longterm strategy for growing, expanding, and exploiting hBECs for subsequent studies of bile duct morphogenesis and tissue engineering of artificial bile ducts.
Simulation of junctionless Si nanowire transistors with 3 nm gate length (2010)

Inspired by recent experimental realizations and theoretical simulations of thin silicon nanowire-based devices, we perform proof-of-concept simulations of junctionless gated Si nanowire transistors. Based on first-principles, our primary predictions are that Si-based transistors are physically possible without major changes in design philosophy at scales of ∼1 nm wire diameter and ∼3 nm gate length, and that the junctionless transistor avoids potentially serious difficulties affecting junctioned channels at these length scales. We also present investigations into atomic-level design factors such as dopant positioning and concentration.
An Antimicrobial Substance Isolated from <i>Ligularia tussilaginea</i> MAKINO (1963)

The leaves of Ligularia tussilaginea MAKINO have been used from olden times as a home remedy for suppurating eruptions, same as Houttuynia cordata THUNB. The crude drug of Ligularia tussilaginea was submitted to low-pressure steam distillation and a substance with an odor of this plant was isolated, which was later identified as 2-hexanal. 2-Hexanal was effective against Staphylococcus pyogenes in 1:5000 dilution and against Trichophyton asteroides in 1:10000 dilution.
Progenitor cell domains in the developing and adult pancreas (2011)

Unlike organs with defined stem cell compartments, such as the intestine, the pancreas has limited capacity to regenerate. The question of whether the adult pancreas harbors facultative stem/progenitor cells has been a prime subject of debate. Cumulative evidence from recent genetic lineage tracing studies, in which specific cell populations were marked and traced in adult mice, suggests that endocrine and acinar cells are no longer generated from progenitors in the adult pancreas. These studies further indicate that adult pancreatic ductal cells are not a source for endocrine cells following pancreatic injury, as previously suggested. Our own studies have shown that adult ductal cells reinitiate expression of some endocrine progenitor markers, including Ngn3, after injury by partial duct ligation (PDL), but that these cells do not undergo endocrine cell differentiation. Here, we present additional evidence that endocrine cells do not arise from ducts following b-cell ablation by streptozotocin or by a diphtheria toxin-expressing transgene or when b-cell ablation is combined with PDL. In this review, we discuss findings from recent lineage tracing studies of embryonic and adult pancreatic ductal cells. Based upon the combined evidence from these studies, we propose that multipotency is associated with a specific transcriptional signature.