gebhart/patrepeval huggingface dataset:
GRANULOMATOUS PROSTATITIS LINKED TO HLA-DRB1*1501 (2004)

The data suggest an association between HLA-DRB1*1501 and granulomatous prostatitis. HLA-DR15 is strongly associated with other autoimmune diseases, notably multiple sclerosis. The data are consistent with an autoimmune etiology for nonspecific granulomatous prostatitis.
Deriving Traceability Relationships of Multiperspective Software Artifacts from Ontology Matching (2009)

Requirements traceability and change management in multiperspective software artifacts is a major challenge due to the heterogeneity of the artifacts themselves. Our previous attempt in resolving such problem results in a multiperspective requirements traceability framework, namely MUPRET. The key idea of MUPRET is to use ontology, so-called requirements ontology, as a common representation of mutual understanding of semantics of words in the requirements sentences. By doing so, the traceability relationships can be automatically generated when a match is found in the requirements ontologies. Although the MUPRET was originally proposed for the textual requirements, this paper presents the extension of MUPRET to cover different representations of software artifacts, together with an illustrative example of the extended applications.
Expression in Escherichia coli of the flavin-containing monooxygenase D (form II) from adult human liver: Determination of a distinct tertiary amine substrate specificity (1993)

The cDNA for a major component of the family of flavin-containing monooxygenases (FMOs) present in adult human liver (i.e., HLFMO-D) has been cloned and expressed in a prokaryotic system. Escherichia coli strain NM522 was transformed with pTrcHLFMO-D, and the HLFMO-D cDNA was expressed under the control of the Trc promoter. A variety of tertiary amine substrates [i.e., chlorpromazine and 10-[(N,N-dimethylamino)alkyl]- 2-(trifluoromethyl)phenothiazines] were efficiently oxygenated by HLFMO-D cDNA expressed in E. coli or by adult human liver microsomes. Approximate dimensions of the substrate binding channel for both adult human liver microsomal FMO and cDNA-expressed HLFMO-D were apparent from an examination of the N-oxygenation of a series of 10-[(N,N-dimethylamino)alkyl]-2-(trifluoromethyl)phenothiazines. The substrate regioselectivity studies suggest that adult human liver FMO form D possesses a distinct substrate specificity compared with form A FMO from animal hepatic sources. It is likely that the substrate specificity observed for cDNA-expressed adult human liver FMO-D may have consequences for the metabolism and distribution of tertiary amines and phosphorus- and sulfur-containing drugs in humans and may provide insight into the physiologic substrate(s) for adult human liver FMO.
Interference-robust serial dual-path threshold referenced architecture for PN acquisition (2002)

We investigate the performance of serial PN acquisition architectures in the presence of noise and interference. In particular, the performance of a low complexity serial correlator with constant threshold (CT) and a dual-path threshold referenced (DPTR) architecture are studied. Using an AWGN channel model, analytical expressions have been derived for the probability of false alarm, the probability of detect, and the mean acquisition time. Simulations have been performed to verify the theoretical analysis. We show that for a practical range of chip-to-noise ratios (CNR), the basic serial correlator yields comparable performance to the dual-path threshold reference method. However, the performance gain of the DPTR architecture is up to 3 dB in CNR or 4 times lower in the mean acquisition time when interference is present in the channel, making this architecture suitable for interference limited environments.
Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia (2013)

Aberrant recombination between T-cell receptor genes and oncogenes gives rise to chromosomal translocations that are genetic hallmarks in several subsets of human T-cell acute lymphoblastic leukemias. The V(D)J recombination machinery has been shown to play a role in the formation of these T-cell receptor translocations. Other, non-T-cell receptor chromosomal aberrations, such as SIL-TAL1 deletions, have likewise been recognized as V(D)J recombination associated aberrations. Despite the postulated role of V(D)J recombination, the extent of the V(D)J recombination machinery involvement in the formation of T-cell receptor and non-T-cell receptor aberrations in T-cell acute lymphoblastic leukemia is still poorly understood. We performed a comprehensive in silico and ex vivo evaluation of 117 breakpoint sites from 22 different T-cell receptor translocation partners as well as 118 breakpoint sites from non-T-cell receptor chromosomal aberrations. Based on this extensive set of breakpoint data, we provide a comprehensive overview of T-cell receptor and oncogene involvement in T-ALL. Moreover, we assessed the role of the V(D)J recombination machinery in the formation of chromosomal aberrations, and propose an up-dated mechanistic classification on how the V(D)J recombination machinery contributes to the formation of T-cell receptor and non-T-cell receptor aberrations in human T-cell acute lymphoblastic leukemia.
Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis (2016)

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentiviral vectors are more efficient for lung gene transfer than non-viral vectors in preclinical models. In preparation for a first-in-man CF trial using the lentiviral vector, we have undertaken key translational preclinical studies. Regulatory-compliant vectors carrying a range of promoter/enhancer elements were assessed in mice and human air-liquid interface (ALI) cultures to select the lead candidate; cystic fibrosis transmembrane conductance receptor (CFTR) expression and function were assessed in CF models using this lead candidate vector. Toxicity was assessed and 'benchmarked' against the leading non-viral formulation recently used in a Phase IIb clinical trial. Integration site profiles were mapped and transduction efficiency determined to inform clinical trial dose-ranging. The impact of pre-existing and acquired immunity against the vector and vector stability in several clinically relevant delivery devices was assessed. A hybrid promoter hybrid cytosine guanine dinucleotide (CpG)- free CMV enhancer/elongation factor 1 alpha promoter (hCEF) consisting of the elongation factor 1α promoter and the cytomegalovirus enhancer was most efficacious in both murine lungs and human ALI cultures (both at least 2-log orders above background). The efficacy (at least 14% of airway cells transduced), toxicity and integration site profile supports further progression towards clinical trial and pre-existing and acquired immune responses do not interfere with vector efficacy. The lead rSIV.F/HN candidate expresses functional CFTR and the vector retains 90-100% transduction efficiency in clinically relevant delivery devices. The data support the progression of the F/HN-pseudotyped lentiviral vector into a first-in-man CF trial in 2017.
Method and apparatus for seismic exploration (1987)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Wayne V. Vogen; Method and apparatus for seismic exploration. J. Acoust. Soc. Am. 1 December 1987; 82 (6): 2165. https://doi.org/10.1121/1.395635 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Natural and synthetic rubbers (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNatural and synthetic rubbersHarry L. Fisher Cite this: J. Chem. Educ. 1942, 19, 11, 522Publication Date (Print):November 1, 1942Publication History Received3 August 2009Published online1 November 1942Published inissue 1 November 1942https://doi.org/10.1021/ed019p522RIGHTS & PERMISSIONSArticle Views100Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (7 MB) Get e-Alerts Get e-Alerts
Preliminary design of a dedicated proton therapy linac (2002)

The preliminary design has been completed for a low-current, compact proton linac dedicated to cancer therapy. A 3-GHz side-coupled structure accelerates the beam from a 70-MeV drift tube linac using commercially available S-band RF power systems and accelerating cavities. This significantly reduces the linac cost and allows incremental energies up to 250 MeV. The short beam pulse width and high repetition rate make the linac similar to the high-energy electron line linacs now used for cancer therapy, yet produce a proton flux sufficient for treatment of large tumors. The high pulse repetition rate permits raster scanning, and the small output beam size and emittance result in a compact isocentric gantry design. It is concluded that a linac will reduce the facility and operating costs for a dedicated cancer therapy system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Depletion of complement and effects on passive transfer of resistance to infection with Borrelia burgdorferi (1991)

When irradiated hamsters are passively immunized with immune serum before challenge with Borrelia burgdorferi, they are completely protected from arthritis and infection. The complement dependency of this protection was addressed by treating hamsters with cobra venom factor. Depletion of complement abrogated the ability of immune serum obtained 1 and 10 weeks after infection to confer complete protection. By contrast, depletion of complement had no effect on the ability of 3-week immune serum to confer protection. These results suggest that complement-dependent, and possibly complement-independent, antibodies are important for preventing the induction of Lyme arthritis.
The USDA's Healthy Eating on a Budget Program: Making Better Eating Decisions on a Budget (2016)

The U.S. Department of Agriculture has launched a new interactive online program titled Healthy Eating on a Budget. It is an addition to the popular ChooseMyPlate.gov programs, such as the SuperTracker program. The Healthy Eating on a Budget program helps consumers plan, purchase, and prepare healthful meals. This article discusses materials and resources that are available as part of the Healthy Eating on a Budget program and provides suggestions for ways in which Extension professionals who teach consumers how to improve their nutrition and make nutrition affordable can use the program.
Probing the interaction between p53 and the bacterial protein azurin by single molecule force spectroscopy (2008)

p53 is a human tumour suppressor which regulates multiple cellular processes, including cell growth, genomic stability and cell death. Recent works have demonstrated the bacterial redox protein azurin to enter cancer cells and induce apoptosis through p53 stabilization, resulting in a tumour growth regression. Azurin has been shown to bind p53 although many details of the complex formed by these two proteins are still poorly characterized. Here, we get insight into the kinetics of this complex formation, by exploring the interaction between p53 and azurin in their environment by single molecule force spectroscopy. To this aim, azurin has been linked to the atomic force microscope tip, whereas p53 has been immobilized onto a gold substrate. Therefore, by performing force-distance cycles we have detected specific recognition events between p53 and azurin, displaying unbinding forces of around 70 pN for an applied loading rate of 3 nN s(-1). The specificity of these events has been assessed by the significant reduction of their frequency observed after blocking the p53 sample by an azurin solution. Moreover, by measuring the rupture force as a function of the loading rate we have determined the dissociation rate constant of this complex to be approximately 0.1 s(-1). Our findings are here discussed in connection with results obtained in bulk experiments, with the aim of clarifying some molecular details of the p53-azurin complex that may help designing new anticancer strategy.
What is the CIM lacking? (2010)

The IEC 61970/61968 Common Information Model is undoubtedly one of the core standards of the future smart grid as pointed out by different organizations and recent standardization roadmaps. Its acceptance in the energy sector and the active standardization work is very high and make it one of the most established standards worldwide in the energy domain. But not all requirements are met by the CIM to be the standard of choice in any possible situation. This work tries to specify some of the main gaps identified in different research projects like in the German e-energy projects and in day-to-day business with electric utility companies and the surrounding industry. There is also the attempt to recommend some known approaches to these gaps and to advise general solutions to encounter problems while using the Common Information Model.
A 50mW-TX 65mW-RX 60GHz 4-element phased-array transceiver with integrated antennas in 65nm CMOS (2013)

The 60GHz band has gained great interest as an enabler for multi-Gb/s wireless links. Recent efforts [1-4] have focused on reducing transceiver power to drive adoption of 60GHz in mobile devices. To further accelerate this adoption, the cost of current mm-Wave solutions should also be reduced. Especially for short range designs (<;1m), overall cost may be dominated by packaging and testing. This paper therefore presents a low-power 60GHz CMOS 4-element phased-array QPSK transceiver with integrated slot-loop antennas. Utilizing such antennas as well as circuit stacking techniques, the transceiver achieves 10.4Gb/s with a range of >40cm in all directions while consuming only 115mW (TX+RX).
Neural computing architectures: the design of brain-like machines (1989)

McClelland and Rumelhart's Parallel Distributed Processing was the first book to present a definitive account of the newly revived connectionist/neural net paradigm for artificial intelligence and cognitive science. While Neural Computing Architectures addresses the same issues, there is little overlap in the research it reports. These 18 contributions provide a timely and informative overview and synopsis of both pioneering and recent European connectionist research. Several chapters focus on cognitive modeling, however, most of the work covered revolves around abstract neural network theory or engineering applications, bringing important complementary perspectives to currently published work in PDP.In four parts, chapters take up neural computing from the classical perspective, including both foundational and current work; the mathematical perspective (of logic, automata theory, and probability theory), presenting less well-known work in which the neuron is modeled as a logic truth function that can be implemented in a direct way as a silicon read only memory. They present new material both in the form of analytical tools and models and as suggestions for implementation in optical form, and summarize the PDP perspective in a single extended chapter covering PDP theory, application, and speculation in U.S. research. Each part is introduced by the editor.Igor Aleksander is Professor of Computer Science at Imperial College in London
An all-CMOS ternary identity cell for VLSI implementation (1984)

A ternary identity cell composed only of CMOS transistors is presented. The circuit has fewer transistors and better performance than that of previously reported designs. A nano-watt power consumption and fast switching time are important advantages that this circuit possesses. Applications include buffers, pad drivers and triflops.
AppMonitor: A tool for recording user actions in unmodified Windows applications (2008)

This article describes AppMonitor, a Microsoft Windows-based client-side logging tool that records user actions in unmodified Windows applications. AppMonitor allows researchers to gain insights into many facets of interface interaction such as command use frequency, behavioral patterns prior to or following command use, and methods of navigating through systems and data sets. AppMonitor uses the Windows SDK libraries to monitor both low-level interactions, such as "left mouse button pressed" and "Ctrl-F pressed," as well as high-level "logical" actions, such as menu selections and scrollbar manipulations. The events recorded are configurable, allowing researchers to perform broad or targeted studies. No user input is required to manage logging, allowing participants to seamlessly conduct everyday work while their actions are monitored. The system currently supports logging in Microsoft Word and Adobe Reader; however, it could be extended for use with any Microsoft Windows-based application. To support other researchers wishing to create multilevel event loggers, we describe AppMonitor's underlying architecture and implementation, and provide a brief example of the data generated during our 4-month trial with six users.
Coordinate Control of Proliferation and Migration by the p27 <sup>Kip1</sup> /Cyclin-Dependent Kinase/Retinoblastoma Pathway in Vascular Smooth Muscle Cells and Fibroblasts (2003)

Previous studies have demonstrated a protective effect of the cyclin-dependent kinase (CDK) inhibitor p27Kip1 against atherosclerosis and restenosis, two disorders characterized by abundant proliferation and migration of vascular smooth muscle cells and adventitial fibroblasts. These therapeutic effects might result from p27Kip1-dependent suppression of both cell proliferation and migration. However, the interplay between cell growth and locomotion remains obscure. We show here that p27Kip1 inhibits cellular changes that normally occur during cell locomotion (eg, lamellipodia formation and reorganization of actin filaments and focal adhesions). Importantly, a p27Kip1 mutant lacking CDK inhibitory activity failed to inhibit vascular smooth muscle cell and fibroblast proliferation and migration. Moreover, a constitutively active mutant of the retinoblastoma protein (pRb) insensitive to CDK-dependent hyperphosphorylation inhibited both cell proliferation and migration. In contrast, inactivation of pRb by forced expression of the adenoviral oncogene E1A correlated with high proliferative and migratory activity. Collectively, these results suggest that cellular proliferation and migration are regulated in a coordinated manner by the p27Kip1/CDK/pRb pathway. These findings might have important implications for the development of novel therapeutic strategies targeting the fibroproliferative/migratory component of vascular occlusive disorders.
»Vaganten« — interdiskursiv (1998)

Die Politiken der Disziplinierung, die sich um den Komplex des Nomadischen in den 20er und 30er Jahren entwickeln, reichen bekanntlich von verschärfter polizeilicher Erfassung über Sterilisationsmaßnahmen bis hin zu Einweisung und Ermordung in Konzentrationslagern.1 Nicht zuletzt erscheint der Völkermord an Sinti und Roma mit dieser verschärften Abwehr des Nomadischen verbunden.2 Während der systematische Genozid gerade das Ereignis »NS«, dessen Besonderheit und insofern die Diskontinuität markiert, ergeben sich bezüglich der Systematik jedoch Kontinuitäten. Zutreffend betont Rainer Hehemann bereits, daß die seit Beginn des Jahrhunderts einsetzende polizeiliche Erfassung und die in den 20er Jahren durch Daktyloskopierung und Lichtbilder angereicherten »Akten« eine Grundlage für Forschung und Vernichtungspolitik des NS geworden ist.3 Akten und Ausweise mit Fingerabdruck und Bild unterstreichen ihrerseits Besonderheiten des historischen Ereignisses in Opposition zu der longue durée des »Zigeunerstereotyps«. Innerhalb der neuen Formierung der Wanderungsbewegungen verändern sich auch dessen Konturen und Funkionsweisen. Denn die Techniken der disziplinierenden Identifizierung gehen einher mit der diskursiven und vor allem symbolischen Konstituierung des »Vaganten«. Grundlegend für die neue Wissensproduktion wird dabei die weitere Ausdifferenzierung des »Wanderns« und seiner Symbolik.
Induction of lateral phase separations in binary lipid mixtures by alcohol (1987)

It has previously been shown that alcohol has different effects on the gel to liquid-crystal phase transition of phosphatidylcholines (PC's) and phosphatidylethanolamines (PE's) [Rowe, E. S. (1985) Biochim. Biophys. Acta 813, 321-330]. In this investigation, the thermotropic properties of binary PE-PC mixtures were studied in the presence of ethanol in order to determine whether the differential interactions of alcohol with PC and PE would lead to lateral phase separations. Phase diagrams of the dilaurylphosphatidylethanolamine-dipalmitoylphosphatidylcholine [PE(12:0)-PC(16:0)] system were constructed in the presence and absence of ethanol. It was shown that lateral phase separations occur in the gel phase over a certain composition range in the presence of 100 mg/mL ethanol. In the absence of alcohol these two lipids are miscible in both the gel and liquid-crystal states. The data suggest that in the presence of ethanol these lateral phase separations involve the coexistence of regular bilayer gel and the fully interdigitated gel phase, which has previously been shown to occur in pure PC(16:0) under these conditions [Simon, S. A., & McIntosh, T. J. (1984) Biochim. Biophys. Acta 773, 169-172]. The biological implications of these findings are discussed.
Maximum Weighted Matching with Interference Constraints (2006)

In this paper, we study the problem of utility maximization in multi-hop wireless systems. To study the effect of wireless interference constraints on the utility maximization problem, we introduce a new class of weighted matching problems, namely maximum weighted K-valid matching problems (MWKVMPs). For K = 1, MWKVMP corresponds to the well studied maximum weighted matching problem (MWMP) in the literature, which can be solved in polynomial time. We prove several interesting results concerning the hardness of these problems for K ges 2. In particular, we show that MWKVMP does not even belong to APX; where APX denotes the class of problems to which a constant factor approximation can be obtained in polynomial time. Our results have strong implications concerning the hardness of scheduling transmissions in multi-hop wireless systems