gebhart/patrepeval huggingface dataset:
Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). (1987)

Several features of activation of mouse peritoneal macrophages were elicited by 1-2-d exposure to submicrogram concentrations of anti-Mac-1 (M1/70), a rat monoclonal antibody that reacts with the alpha chain of complement receptor type 3 (Mac-1). The changes induced included enhanced capacity to secrete H2O2 when triggered with PMA, decreased secretion of proteins, increased expression of Ia antigen and decreased phagocytosis of particles. These changes closely resembled those induced by rIFN-gamma in type, extent, and time course. The concentration of M1/70 IgG resulting in 50% of the maximal activation of macrophage H2O2-releasing capacity averaged 0.18 +/- 0.03 micrograms/ml. This activation was not blocked by anti-FcR mAb, and could be reproduced with M18/2, a mAb against beta chain of Mac-1, suggesting that a direct ligation of Mac-1 with mAb was responsible for the activation. Neither depletion of T cells nor addition of neutralizing Abs to IFN-gamma or TNF-alpha prevented M1/70-mediated macrophage activation. Moreover, F(ab')2 of M1/70, or plating of macrophages on C3bi-coated surfaces, inhibited the activation of macrophages by rIFN-gamma. These findings suggest that Mac-1 (CR3) may play an important role in macrophage activation.
Snuffers (1992)

[Heb mĕzammĕrōt; melqāḥayim]. Metal instruments used in connection with the lamps in the Tabernacle and Temple. Those used in the Tabernacle were made of gold (Exod 25:38; 37:23; Num 4:9) and are known in Hebrew as melqāḥayim, a word also used in the temple text in Kings, where RSV renders it “tongs
Genome‐Wide Association Study Confirms SNPs in <i>SNCA</i> and the <i>MAPT</i> Region as Common Risk Factors for Parkinson Disease (2010)

Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7 x 10(-8); genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17-1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p-value = 5.6 x 10(-8); genome-wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62-0.79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD.
<title>VC collaborator: a mechanism for video conferencing support</title> (1996)

Currently available video conferencing (VC) tools lack support for adaptability and session recording features. Incorporating adaptability in a system minimizes the effects of the variations in system environments on the quality of video conference sessions. Support for session recording features provides the capability of saving video sessions when the quality of service becomes unacceptable or when some of the recipients become unreachable. The latter situation arises due to network partitioning or site failures. Furthermore, recording a session is also useful when the recorded video session is expected to be replayed and retrieved by future users interested in it. In this paper, techniques for making video conferencing tools adaptable to the external environmental changes are presented. A new mechanism called video conferencing collaborator, which integrates the VC software with the video-on-demand system is introduced, and its design and implementation issues are addressed. We present the results of experiments conducted to study the potential performance improvements if the adaptability features are included in VC software. We conclude the paper with directions for our future work.
Coupled Quantum Dots in a Graphene-Based Two-Dimensional Semimetal (2009)

We present an experimental demonstration of a graphene-based double quantum dot system, which exhibits single-electron transport of two lateral quantum dots coupled in series. Low-temperature transport measurements revealed honeycomb charge stability diagrams with a varied (from weak to strong) interdot tunnel-coupling regime, and we have extracted the relevant parameters associated with the double quantum dot system. These results are important for the realization of integrated quantum circuits in graphene-based electronics.
Exchange Protein Directly Activated by cAMP Mediates Slow Delayed-Rectifier Current Remodeling by Sustained β-Adrenergic Activation in Guinea Pig Hearts (2014)

Prolonged β1-adrenoceptor stimulation suppresses IKs by downregulating KCNE1 mRNA and protein via Epac-mediated Ca(2+)/calcineurin/NFAT signaling. These results provide new insights into the molecular basis of K(+) channel remodeling under sustained adrenergic stimulation.
Neuraminidase Activity in Middle Ear Effusions (1984)

Analyses of Streptococcus pneumoniae culture filtrates and middle ear effusions (MEE) containing S pneumoniae for various hydrolytic enzymes have demonstrated substantial levels of neuraminidase activity when measured employing a sensitive fluorometric assay. S pneumoniae neuraminidase exhibits optimum activity near neutral pH (6.0 to 6.5), and catalyzes the cleavage of sialic acid residues from glycoproteins, gangliosides and mucopolysaccharides. S pneumoniae begins secreting large amounts of neutral neuraminidase (mean [means] = 43.3 units/mL culture filtrate) when cells enter the stationary phase. Nearly all (96%) human chronic MEEs yielding positive cultures for S pneumoniae contain neuraminidase activity (means = 0.200 units/mg protein), while only 21.1% to 45.5% of all other effusions contain the enzyme. Middle ear effusions obtained from S pneumoniae infected-chinchillas contained large amounts of neuraminidase activity (approximately 200 units/mL), which decayed exponentially in vivo with an apparent half-life of 8 1/2 days. Three neuraminidase isoenzymes (designated I-III) were identified in S pneumoniae culture filtrates, as well as in MEEs from chinchillas infected with the organism, using a combination of ion-exchange and gel filtration chromatography. With 4-methylumbelliferyl-N-acetylneuraminic acid serving as substrate, preparation I from both culture filtrates and MEEs was characterized by a high Michaelis constant (Km), while forms II and III had low Km values. Preferred substrates were orosomucoid and neuramin-lactose; gangliosides, thyroglobulin, and bovine submaxillary mucin were poorer substrates.
Synthesis and biological activities of glycoconjugated spiro triones. (2009)

Malonic acid undergoes condensation readily with ureas to yield barbituric acids 2 which on bromination give 5,5-dibromobarbituric acids 3. Reaction of α-D-glucose with these 5,5-dibromo barbituric acids afforded 2,3-α-Dglucopyrano-1,4-dioxo-7,9-diaza-spiro[4,5]deca-6,8,10-triones 4. The structures of the products have been assigned on the basis of H NMR, C NMR, ES-MS, optical activity and elemental analysis. The compounds are found to have antibacterial and antifungal activities.
Cancer vaccines: reborn or just recycled? (1998)

The field of human cancer vaccines is currently undergoing a revival. This volume describes a variety of approaches to active immunotherapy, some traditional and some more technologically sophisticated. Interpretation of their claims to clinical efficacy requires an understanding of some of the principles of tumor immunotherapy. These include the following: (1) human cancers are weakly immunogenic or not immunogenic at all; (2) cell-mediated immune responses, mainly those of T lymphocytes, are critical to tumor rejection; (3) almost nothing is known about the nature of the rejection antigens on human tumors; (4) it is not clear whether these antigens are different for each case of human cancer or whether there are clinically useful antigens that are shared by all or most tumors of a given histologic type; and (5) the effectiveness of vaccines is greatly limited by excessive tumor burden. The reader is invited to approach this collection of papers with a combination of optimism and skepticism.
Regulation of glucose and glycogen metabolism during and after exercise (2011)

Utilization of carbohydrate in the form of intramuscular glycogen stores and glucose delivered from plasma becomes an increasingly important energy substrate to the working muscle with increasing exercise intensity. This review gives an update on the molecular signals by which glucose transport is increased in the contracting muscle followed by a discussion of glycogen mobilization and synthesis by the action of glycogen phosphorylase and glycogen synthase, respectively. Finally, this review deals with the signalling relaying the well-described increased sensitivity of glucose transport to insulin in the post-exercise period which can result in an overshoot of intramuscular glycogen resynthesis post exercise (glycogen supercompensation).
<title>Low-temperature direct bonding using pressure and temperature</title> (1997)

We have developed a three-step process to low temperature direct bond silicon and/or SiO<SUB>2</SUB> surfaces. The process activates the surface with various plasma treatments including NH<SUB>3</SUB>, Ar and O. These activation processes allow a very strong low temperature bond to be created. The process requires techniques distinctly different from those found in previous work for reproducible results. The plasma processes do not result in a bond that propagates as a wave resulting from a point source initiation. A substantial pressure is required to initiate the bond. We have found that the three-step process using pressure and temperature results in very strong, reproducible bonds. The basic process consists of 1) the application of pressure for a period of 10 minutes, followed by 2) pressure and low temperature for another 30 minutes at 200 degrees C and finally 3) an anneal at low temperature of 200 degrees C for 24 hours. The bonds created by this process have a strength > 1000 ergs/cm<SUP>2</SUP>, which compares favorably with a conventional direct bond requiring an anneal > 1000 degrees C.
Measuring and managing customer value (2002)

Customer value management (CVM) aims to improve the productivity of marketing activity, and the profitability of business by identifying the value of different customer segments and aligning marketing strategies, plans and resourcing accordingly. There are two complementary approaches to CVM. The first attempts to measure and evaluate the perceived value placed on goods/services by customers. This information is used as the basis of continuous review and improvement of those goods/services. The second approach measures the value of specific customers, or customer segments, to the organisation and uses this to tailor marketing activity. Addressed together these approaches ensure that both sides of a business relationship gain added value. This paper explains the concept of CVM and key issues in using it to drive more effective marketing activity.
Sexual Function in Women With Urinary Incontinence and Pelvic Organ Prolapse (2002)

In Brief OBJECTIVE To compare sexual function in women with urinary incontinence and pelvic organ prolapse and to determine the effects of therapy on sexual function. METHODS 343 community-dwelling women older than 45 years with urinary incontinence or advanced prolapse were recruited into a multi-armed clinical trial. Women with incontinence were stratified to receive estrogen therapy, behavioral therapy, or surgical therapy. Women with prolapse were enrolled in a randomized surgical trial. All women completed a standardized urogynecologic evaluation and a sexual function questionnaire at baseline and after therapy. RESULTS Women with prolapse or detrusor instability were more likely to cite pelvic floor symptoms as a reason for sexual inactivity than were women with other conditions. One third of patients with prolapse reported that their pelvic floor condition affected their ability to have sexual relations "moderately" or "greatly" significantly more than did other groups. Patients with genuine stress incontinence who underwent surgical or behavioral therapy were less likely to report being worried about urine leakage during intercourse after therapy than at baseline. After surgery, women with prolapse were less likely to report that their symptoms affected their ability to have sexual relations compared with baseline. Overall sexual satisfaction was the same at baseline and remained unchanged in all therapeutic groups at 6 months. CONCLUSION Prolapse is more likely than urinary incontinence to result in sexual inactivity and to be perceived as affecting sexual relations. However, overall sexual satisfaction appears to be independent of diagnosis of or therapy for urinary incontinence or prolapse. Pelvic organ prolapse is more likely to be perceived as affecting sexual relations than is urinary incontinence, but treatment decreases this perceived impact in most women.
Chemically Tailored, Corrosion Resistant, High-Tc Phases (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemically Tailored, Corrosion Resistant, High-Tc PhasesJi-Ping Zhou, Steven M. Savoy, Jianai Zhao, David R. Riley, Y. T. Zhu, A. Manthiram, Rung-Kuang Lo, Damon Borich, and John T. McDevittCite this: J. Am. Chem. Soc. 1994, 116, 20, 9389–9390Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ja00099a090https://doi.org/10.1021/ja00099a090research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Immunomodulatory Activity of the Water Extract from Medicinal Mushroom<i>Inonotus obliquus</i> (2005)

The immunomodulatory effect of aqueous extract of Inonotus obliquus, called as Chaga, was tested on bone marrow cells from chemically immunosuppressed mice. The Chaga water extract was daily administered for 24 days to mice that had been treated with cyclophosphamide (400 mg/kg body weight), immunosuppressive alkylating agent. The number of colony-forming unit (CFU)-granulocytes/macrophages (GM) and erythroid burst-forming unit (BFU-E), increased almost to the levels seen in non-treated control as early as 8 days after treatment. Oral administration of the extract highly increased serum levels of IL-6. Also, the level of TNF-α was elevated by the chemical treatment in control mice, whereas was maintained at the background level in the extract-treated mice, indicating that the extract might effectively suppress TNF-α related pathologic conditions. These results strongly suggest the great potential of the aqueous extract from Inonotus obliquus as immune enhancer during chemotherapy.
Surface characterization of oil-containing polyterephthalamide microcapsules prepared by Interfacial polymerization (2001)

Oil-containing polyterephthalamide microcapsules were synthesized by the interfacial polymerization of an oil-soluble monomer (terephthaloyl dichloride, TDC) and a mixture of two water-soluble monomers (diethylenetriamine, DETA, and 1, 6-hexamethylenediamine, HMDA). The influence of several synthesis parameters (e.g. concentration ratio of the two amine monomers, stirring rate, concentration of the steric stabilizer PVA) on the size distribution, the membrane morphology and the electrokinetic properties of the microcapsules, was thoroughly investigated. Morphological analysis by electron microscopy showed a strong dependence of the membrane external morphology on the functionality of the water-soluble amine monomer. High stabilizer concentrations and agitation rates during emulsification favoured the production of smaller microcapsules with non-porous and rigid membranes. The electro-chemical interfacial properties of the microcapsules were investigated using a combination of potentiometric, conductimetric and electrokinetic measurements. The dependence of the mean surface charge density on pH revealed the presence of essentially two kinds of chemical groups (e.g. amino and carboxylic groups) on the microcapsule external surface. The total concentration of surface chemical groups and the isoelectric pH were measured as a function of the microcapsule synthesis conditions. Using the experimental data and an appropriate interfacial ionization model, the ratio of the surface groups densities, R = (S - COOH)/(S NH3(+) ), was evaluated and rationalized with respect to the microcapsules synthesis parameters.
A modular control system for warehouse automation - algorithms and simulations in USARSim (2012)

In this paper, we present a control system for a fully autonomous material handling facility. The scenario we are considering is motivated by the 2011 IEEE Virtual Manufacturing Automation Challenge (VMAC). It consists of multiple autonomously guided vehicles (AGVs), transporting pallets of various goods between several input and output locations, through an unstructured warehouse environment. Only a map of the warehouse and a pallet delivery list are provided a priori. Pallets must be delivered to the output locations in the shortest time possible, while respecting the ordering of different pallet types specified by the delivery list. The presented control system handles all aspects of warehouse operation, from individual vehicle control to high-level mission planning and coordination. Delivery mission assignments are optimized using dynamic programming and simulated annealing techniques. Mission executions are coordinated using graph search methods and a modified version of the Banker's algorithm, to ensure safe, collision and deadlock-free system operation. System performance is evaluated on a virtual warehouse model, using the high fidelity USARSim simulator.
Epstein–Barr Virus and Cancer (2018)

Epstein-Barr virus (EBV) contributes to about 1.5% of all cases of human cancer worldwide, and viral genes are expressed in the malignant cells. EBV also very efficiently causes the proliferation of infected human B lymphocytes. The functions of the viral proteins and small RNAs that may contribute to EBV-associated cancers are becoming increasingly clear, and a broader understanding of the sequence variation of the virus genome has helped to interpret their roles. The improved understanding of the mechanisms of these cancers means that there are great opportunities for the early diagnosis of treatable stages of EBV-associated cancers and the use of immunotherapy to target EBV-infected cells or overcome immune evasion. There is also scope for preventing disease by immunization and for developing therapeutic agents that target the EBV gene products expressed in the cancers.
Locating Query-oriented Experts in Microblog Search. (2014)

In this paper, we propose an approach to locating queryoriented experts in Microblog. We first define the experts by social influence and content relevance. Then, we adopt the BM25 model to calculate the content relevance of each account. For the social influence, we present a global-ranking algorithm as GUserRank and a topic-ranking algorithm as TUserRank after applying the LDA topic model. After that, we output the ranking expertise degree of each candidate for evaluation. Our experimental results show that the proposed approach is effective and promising. Especially, the topic-ranking algorithm achieves an improvement with 40.11% over the baseline. Furthermore, our approach does not rely on the data sets such that it can be duplicated in many fields.
Femeile din Viaţa lui Petru Cercel (2013)

Abstract Le travail fait suite à une importante analyse des rapports entre Pierre Boucle d'Oreille (Petru Cercel), le voïvode de Valachie, et les fammes. Nous avons participer aux discussions sur les fammes dans la famille de prince, sur les implicates fammes dans la diplomatie et de sur la correspondance diplomatique entre prince et les fammes, sur les maîtresses et sur les femmes enemies du Pierre.
On Cardioactive Steroids. VIII. The Synthesis of Bufalin and Resibufogenin Isomers (1982)

Abstract α‐Isobufalin Systematic names are given at the titles of the Exper. Part . ( 1 ) and β‐isoresibufogenin ( 3 ) have been synthesized from testosterone by a method which features a novel oxidative furan to pyrone transformation.
[Immune response to HSP70-HBcAg(18-27) complex in HBV transgenic mice]. (2007)

HSP70-HBcAg(18-27) complex has an immunological antigenicity in raising the immunoresponse to chronic HBV infection in HBV transgenic mice. HSP70-HBcAg(18-27) complex might be considered as a candidate for further studies on its role as a therapeutic vaccine against chronic HBV infection in humans.
Bronchodilating effect of KC-404, a novel anti-asthmatic agent, and its derivatives in monkey. (1986)

The inhibitory effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine (KC-404) on aerosolized methacholine- and histamine-induced increase in total respiratory resistance (Rrs) was determined in monkeys using the forced 3 Hz oscillation method and was compared with the effect of aminophylline. The effects of several derivatives of KC-404 on methacholine-induced bronchoconstriction were also determined. All of the i.v. administered pyrazolopyridine derivatives showed an inhibition of the increase in Rrs induced by aerosolized methacholine. Among these derivatives, KC-404 exerted the most potent bronchodilating effect. KC-404 also inhibited the histamine-induced increase in Rrs. These effects of KC-404 were more potent than those of aminophylline. On the other hand, the dose of KC-404 tested caused an increase in heart rate, although the degree was moderate as compared with aminophylline. From the results obtained in this study, it is considered that the pyrazolopyridine derivatives, particularly KC-404, may be promising bronchodilators for the treatment of bronchial asthma.
Bacteriophage-resistant mutants of Salmonella typhimurium deficient in two major outer membrane proteins (1976)

Mutants resistant to bacteriophages (P221 and PH105 or PH51) were isolated from a rfa strain of Salmonella typhimurium. They were found deficient in separate 33,000- to 36,000-dalton band proteins (major band proteins). Double mutants derived from both types of mutants were deficient in both of the bands. The growth behavior of all the mutants was normal. The outer membrane of the mutants appeared to be more wrinkled than normal and formed vesicles in many of the mutants. In freeze-fractured cells, changes were seen in the outer membrane (particleless patches in the concave fracture face, the particles themselves being smaller than normal). These changes were more marked in the double mutants.