gebhart/patrepeval huggingface dataset:
Interleukin-1 induces major phenotypic changes in human skin microvascular endothelial cells (1997)

To determine the role of the pleiotropic cytokine interleukin-1 (IL-1) on the activation of endothelial cells during inflammation and angiogenesis, pure populations of human dermal microvascular endothelial cells (HDMEC) were obtained by immunoaffinity purification using Ulex europaeus agglutinin-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1) antibody. Exposure of HDMEC to IL-1beta induced morphologic and physiologic changes characterized by 1) phenotypic modulation of endothelial cells from epithelioid to spindle-shaped cells accompanied by reorganization of vimentin filaments; 2) gradual decrease to a complete absence of the endothelial cell markers von Willebrand factor (vWf) and PECAM-1; and 3) increased capability to form tubule-like structures when overlaid with collagen gels. The IL-1 effect on cell morphology, growth, and decrease of endothelial cell antigens was potentiated by basic fibroblast growth factor (bFGF). Similar results were observed in mitotically arrested gamma-irradiated cells demonstrating that the spindle-shaped cells observed after IL-1 stimulation were derived from epithelioid endothelial cells and that DNA synthesis was not required to effect these changes. Immunostaining with an antibody specific for human fibroblasts was negative and further confirmed the endothelial cell origin of the spindle-shaped cells. These data demonstrate that IL-1 can induce phenotypic changes in HDMEC from epithelioid to spindle-shaped, mesenchymal-like cells, that these cells are more susceptible to stimulation by bFGF, and that they lose biochemical and functional properties characteristic of epithelioid HDMEC.
New Treatment for Ethylene Glycol Poisoning (1999)

Ethylene glycol poisoning has it all. It is a medical emergency with well-defined clinical stages resulting from an intriguing pathophysiologic process that can be explained by applied biochemistry.1 The morbidity and mortality associated with untreated ethylene glycol poisoning are high, but with early diagnosis and effective treatment, the mortality is close to nil.1,2 Therefore, cases of ethylene glycol poisoning are regularly studied as clinicopathological exercises by medical students and residents.3 In my experience, it is hard to find a more challenging type of case to discuss.Ethylene glycol is the chief component of antifreeze fluid. When it is ingested, . . .
Spatial amplitude and phase modulation using commercial twisted nematic LCDs (2008)

We present a method for full spatial phase and amplitude control of a laser beam using a twisted nematic LCD combined with a spatial filter. By spatial filtering we combine four neighboring pixels into one superpixel. At each superpixel we are able to independently modulate the phase and the amplitude of light. We experimentally demonstrate the independent phase and amplitude modulation using this novel technique. Our technique does not impose special requirements on the spatial light modulator and allows precise control of fields even with imperfect modulators.
Chatter--a conversational telephone agent (1993)

Thesis (M.S.)--Massachusetts Institute of Technology, Program in Media Arts & Sciences, 1993.
Test on Sound Transmission Characteristic of PTFE Micro-Aperture Membrane (2009)

: It is a test of sound transmission characteristic of PTFE Micro-aperture Membrane,through it we found that the PTFE Micro-aperture Membrane is an excellent material of sound transmission for its special structure, though the basic rule is of no difference from normal material. Something more important, from test data, it was discovered that PTFE will not affect sound transmission when aperture diameter reaches 0.22m, which is valuable for the research of sound transmission on Micro-aperture.
Kinetics of silver(I)-catalyzed oxidation of formic acid by the (ethylenebis(biguanidine))silver(III) cation in acid perchlorate media (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of silver(I)-catalyzed oxidation of formic acid by the (ethylenebis(biguanidine))silver(III) cation in acid perchlorate mediaRupendranath Banerjee, Kaushik Das, Amitava Das, and Subrata DasguptaCite this: Inorg. Chem. 1989, 28, 3, 585–588Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/ic00302a038https://doi.org/10.1021/ic00302a038research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice (2005)

One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3beta and the consequent activation of canonical Wnt signaling. Because deficient Wnt signaling has been implicated in disorders of reduced bone mass, we tested whether lithium could improve bone mass in mice. We gavage-fed lithium chloride to 8-week-old mice from three different strains (Lrp5(-/-), SAMP6, and C57BL/6) and assessed the effect on bone metabolism after 4 weeks of therapy. Lrp5(-/-) mice lack the Wnt coreceptor low-density lipoprotein receptor-related protein 5 and have markedly reduced bone mass. Lithium, which is predicted to act downstream of this receptor, restored bone metabolism and bone mass to near wild-type levels in these mice. SAMP6 mice have accelerated osteoporosis due to inadequate osteoblast renewal. Lithium significantly improved bone mass in these mice and in wild-type C57BL/6 mice. We found that lithium activated canonical Wnt signaling in cultured calvarial osteoblasts from Lrp5(-/-) mice ex vivo and that lithium-treated mice had increased expression of Wnt-responsive genes in their bone marrow cells in vivo. These data lead us to conclude that lithium enhances bone formation and improves bone mass in mice and that it may do so via activation of the canonical Wnt pathway. Lithium has been used safely and effectively for over half a century in the treatment of bipolar illness. Prospective studies in patients receiving lithium should determine whether it also improves bone mass in humans.
The Effect of Charge Traps on Raman Spectroscopy Using a Thomson-CSF Charge Coupled Device Detector (1990)

Charge coupled device (CCD) detectors have seen increasing use in analytical spectroscopy in recent years. These detectors are optical array detectors based on silicon-metal oxide semiconductor technology. The basis of operation, the characteristics, and the modes of operation in a variety of analytical spectroscopies have recently been discussed in several excellent reviews by Denton and co-workers.
β-Amyloid precursor protein (APP) and the human diseases (2019)

Several pathophysiological functions of the human β-amyloid precursor protein (APP) have been recently proposed in different human diseases such as neurodevelopmental and neurodegenerative disorders including rare diseases such as autism, fragile X syndrome, amyotrophic lateral sclerosis, multiple sclerosis, Lesch-Nyhan disease; common and complex disorders such as Alzheimer's disease; metabolic disorders such as diabetes; and also cancer. APP as well as all of its proteolytic fragments including the amyloid-β (Aβ) peptide, are part of normal physiology. The targeting of the components of APP proteolytic processing as a pharmacologic strategy will not be without consequences. Recent research results highlight the impact of alternative splicing (AS) process on human disease, and may provide new directions for the research on the impact of the human APP on human diseases. The identification of molecules capable of correcting and/or inhibiting pathological splicing events is therefore an important issue for future therapeutic approaches. To this end, the defective APP-mRNA isoform responsible for the disease in cells and tissues appears as an ideal target for epigenetic therapeutic intervention and antisense drugs are potential treatment.
Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA (2014)

RNAi technology is taking strong position among the key therapeutic modalities, with dozens of siRNA-based programs entering and successfully progressing through clinical stages of drug development. To further explore potentials of RNAi technology as therapeutics, we engineered and tested VEGFR2 siRNA molecules specifically targeted to tumors through covalently conjugated cyclo(Arg-Gly-Asp-d-Phe-Lys[PEG-MAL]) (cRGD) peptide, known to bind αvβ3 integrin receptors. cRGD-siRNAs were demonstrated to specifically enter and silence targeted genes in cultured αvβ3 positive human cells (HUVEC). Microinjection of zebrafish blastocysts with VEGFR2 cRGD-siRNA resulted in specific inhibition of blood vessel growth. In tumor-bearing mice, intravenously injected cRGD-siRNA molecules generated no innate immune response and bio-distributed to tumor tissues. Continuous systemic delivery of two different VEGFR2 cRGD-siRNAs resulted in down-regulation of corresponding mRNA (55 and 45%) and protein (65 and 45%) in tumors, as well as in overall reduction of tumor volume (90 and 70%). These findings demonstrate strong potential of cRGD-siRNA molecules as anti-tumor therapy.
Magnetoresistive chip cytometer (2011)

Although conventional state-of-the-art flow cytometry systems provide rapid and reliable analytical capacities, they are bulky, expensive and complex. To overcome these drawbacks modern flow cytometers have been developed with enhanced portability for on-site measurements. Unlike external fluorescent/optical detectors, magnetoresistive sensors are micro-fabricated, can be integrated within microfluidic channels, and can detect magnetically labelled cells. This work describes the real-time detection of single magnetically labelled cells with a magnetoresistive based cell cytometer. For Kg1-a cells magnetically labelled with 50 nm CD34 microbeads (Milteny) flowing through a 150 μm wide, 14 μm high microchannel, with speeds around 1 cm s(-1), bipolar signals with an average amplitude of 10-20 μV were observed corresponding to cell events. The number of cells counted by the spin valve cytometer has been compared with that obtained with a hemocytometer. Both methods agree within the respective error bars.
Development of Protoporphyrinogen Oxidase as an Efficient Selection Marker for<i>Agrobacterium tumefaciens</i>-Mediated Transformation of Maize (2003)

In this article, we report the isolation of plant protoporphyrinogen oxidase (PPO) genes and the isolation of herbicide-tolerant mutants. Subsequently, an Arabidopsis double mutant (Y426M + S305L) was used to develop a selectable marker system for Agrobacterium tumefaciens-mediated transformation of maize (Zea mays) and to obtain multiple events tolerant to the PPO family of herbicides. Maize transformants were produced via butafenacil selection using a flexible light regime to increase selection pressure. Butafenacil selection per se did not change transgene copy number distribution relative to other selectable marker systems, but the most tolerant events identified in the greenhouse were more likely to contain multiple copies of the introduced mutant PPO gene. To date, more than 2,500 independent transgenic maize events have been produced using butafenacil selection. The high frequency of A. tumefaciens-mediated transformation via PPO selection enabled us to obtain single-copy transgenic maize lines tolerant to field levels of butafenacil.
Controlling the synthesis of degradable vinyl polymers by xanthate-mediated polymerization (2015)

The copolymerization of vinyl acetate (VAc) and 2-methylene-1,3-dioxepane (MDO), as well as the homopolymerization of MDO in the presence of a <italic>p</italic>-methoxyphenyl xanthate chain transfer agent (CTA) is reported and comparison of the homopolymerization of MDO with other known xanthates was also investigated.
Caspase-mediated processing of the <i>Drosophila</i> NF-κB factor Relish (2003)

The NF-kappaB-like transcription factor Relish plays a central role in the innate immune response of Drosophila. Unlike other NF-kappaB proteins, Relish is activated by endoproteolytic cleavage to generate a DNA-binding Rel homology domain and a stable IkappaB-like fragment. This signal-induced endoproteolysis requires the activity of several gene products, including the IkappaB kinase complex and the caspase Dredd. Here we used mutational analysis and protein microsequencing to demonstrate that a caspase target site, located in the linker region between the Rel and the IkappaB-like domain, is the site of signal-dependent cleavage. We also show physical interaction between Relish and Dredd, suggesting that Dredd indeed is the Relish endoprotease. In addition to the caspase target site, the C-terminal 107 aa of Relish are required for endoproteolysis and signal-dependent phosphorylation by the Drosophila IkappaB kinase beta. Finally, an N-terminal serine-rich region in Relish and the PEST domain were found to negatively regulate Relish activation.
Biological study of the coccinellid predator, Stethorus punctillum under different constant temperatures (2009)

The ladybeetle, Stethorus punctillum Wiese (Coccinellidae: Coleoptera), is one of the common predators for the two-spotted spider mite, Tetranychus urticae (Koch.). When this predator was reared under different constant temperatures (15, 25 and 35°C), the duration of all stages decreased with increasing temperature. The optimum rearing temperature for this predator under laboratory conditions was found to be 25°C. When the predator feed on alternative food source we found that no oviposition was recorded on any alternative foods, therefore, no eggs were deposited. There were difference in adult S. punctillum longevity associated with different alternative food they feed, the longest period recorded was 12.70 days when the predator feed on a mixture of honey droplets, pollen grains and royal jelly. The shortest periods recorded was 3.75 days when the predator was starved or 3.90 days when feed on aphid.
Auditory model based modified MFCC features (2010)

Using spectral and spectro-temporal auditory models, we develop a computationally simple feature vector based on the design architecture of existing mel frequency cepstral coefficients (MFCCs). Along with the use of an optimized static function to compress a set of filter bank energies, we propose to use a memory-based adaptive compression function to incorporate the behavior of human auditory response across time and frequency. We show that a significant improvement in automatic speech recognition (ASR) performance is obtained for any environmental condition, clean as well as noisy.
Enhanced D-Tree - An Index Structure For Window Queries In Location Based Services (2008)

Location based services is considered as a killer application in the wireless data market that provide information based on locations specified in the queries. We consider wireless data broadcasting as a way of disseminating information to a massive number of users. To address the issues of responsiveness, energy consumption and bandwidth contention in wireless communications, an index has to minimize the search time and maintain a small storage overhead. A linear index structure based on the D-tree is used to support location dependent queries, which is reduced to planar point queries. In this paper, we propose a modified D-tree index structure for processing location dependent information focusing on window queries via wireless data broadcast in a mobile environment. Hilbert curve is used to reduce the data regions that have to be searched from the whole space. Filtering mechanisms are used to find the real answer set. To improve the query processing two techniques namely, fixed grid assignment by which the given space is partitioned into several disjoint sub-grids and caching mechanism that improves access latency were used.
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. (1991)

Cystic fibrosis (CF) is characterized by an abnormality in cAMP-regulated chloride transport that results from a primary defect in the protein product of the CF gene, the CF transmembrane conductance regulator (CFTR). In this report, antibodies against CFTR peptides were used to localize the CFTR protein in human pancreas. An affinity purified antibody (alpha-1468) raised against a synthetic CFTR peptide identified a 155-170-kD protein on immunoblot. Cytochemical studies with alpha-1468 localized CFTR to small branching, tubular structures. The same structures were recognized by two other antibodies raised against different regions of the CFTR molecule. To identify the cells being stained, double-label immunofluorescence studies were performed using alpha-1468 and a monoclonal antibody which stains pancreatic centroacinar and intralobular duct cells. Both antibodies localized to the same population of cells, with alpha-1468 being confined to the apical domain of these cells. No conclusive staining of acinar cells was evident. These findings suggest that proximal duct epithelial cells play a key role in the early events leading to pancreatic insufficiency in CF, and imply that apical chloride transport by these cells is essential for normal pancreatic secretory function.
Cretaceous geology of Lower California (1935)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Research on Characteristics of Chaotic Motion Based on the Wavelet Ridge (2011)

The wavelet ridge method to analyze chaos is described, and the wavelet ridge method is applied to analysis of the nonlinear vibration of blooming mill which exists chaos. The results show that the wavelet ridge can tell the periodic motion, quasi-periodic motion or chaotic motion by analysising the time history of one component of the system state variables. Compared to the other researching methods, such as the Poincaré sections or the phase diagram, we can find the wavelet ridge is more suitable to high dimensional chaotic systems and the clutter of instantaneous frequency which is represented by the wavelet ridge can distinguish between strong and week chaos motion. And it can provide more accurate partial details and features of chaotic motion.
Rating Journals in Health Care Administration by the Textbook Citation Method (1993)

termined by a complex process involving the opinions of scholars, researchers, consumers of scientific information, the opinions of media sources, and the development of scientific knowledge over time. The study of the reputations of journals is a complex affair, involving differing methodologies. In a recent article published in Medical Care, Brooks, Walker and Szorady1 rate journals in health care administration. The rating of journals is accomplished according to the perceptions of program chairpersons in health care administration. A total of 52
Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery (2008)

There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men (2017)

Corcept Therapeutics.
Polarization filter with singular value decomposition (2000)

Abstract We present a singular value decomposition (SVD) based algorithm for polarization filtering of triaxial seismic recordings based on the assumption that the particle motion trajectory is essentially 2-D (elliptical polarization). The filter is the sum of the first two eigenimages of the SVD on the signal matrix. Weighing functions, which are strictly dependent on the intensity (linearity and planarity) of the polarization, are applied. The efficiency of the filter is tested on synthetic traces and on real data, and found to be superior to solely covariance-based filter algorithms. Although SVD and covariance-based methods have similar theoretical approach to the solution of the eigenvalue problem, SVD does not require any further rotation along the polarization ellipsoid principal axes. The algorithm presented here is a robust and fast filter that properly reproduces polarization attributes, amplitude, and phase of the original signal. A major novelty is the enhancement of both elliptical and linear polarized signals. Moreover as SVD preserves the amplitude ratios across the triaxial recordings, the particle motion ellipse before and after filtering retains a correct orientation, overcoming a typical artifact of the covariance-based methods.
Novel Method for Detection, Typing, and Quantification of Human Papillomaviruses in Clinical Samples (2001)

We report the development of a novel detection and typing methodology for human papillomaviruses (HPV) based on real-time PCR with the self-probing fluorescent primers known as Scorpions. This technique is quick, simple, specific, sensitive, and capable of estimating viral load per cell. We report the results of over 100 typing reactions performed on cell lines, biopsies, and cervical cytobrush samples which, when compared to the current reference HPV detection and typing technique, present a kappa value of 0.89. We further report preliminary data suggesting a relationship between viral load per cell and grade of cervical disease.
Novel Rh(I)-Catalyzed Reaction of Arylzinc Compounds with Methyl Halides (1999)

Abstract The cross-coupling reactions of arylzinc compounds with methyl iodide or substituted methyl halides like benzyl bromides took place smoothly by the catalysis of Rh(I)-dppf complex.
Permanent Fiber Optic Monitoring at Northstar: Pressure/Temperature System and Data Overview (2002)

Abstract In-well fiber optic sensing systems offer the potential for continuous, high accuracy, high reliability data measurements. Over the past two years, permanent downhole fiber optic pressure and temperature monitoring has become an accepted new technology in the oil and gas industry. Northstar, on the North Slope of Alaska, represents the first multi-well, new field development to incorporate downhole fiber optic pressure and temperature monitoring. This paper will describe the fiber optic pressure and temperature systems being installed at Northstar. Data collection, data management, and data application will be discussed and examples of data from the first installations will be given.