gebhart/patrepeval huggingface dataset:
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium (2003)

Limited oxygen delivery to tissues (hypoxia) is common in a variety of disease states. A number of parallels exist between hypoxia and acute inflammation, including the observation that both influence vascular permeability. As such, we compared the functional influence of activated polymorphonuclear leukocytes (PMN) on normoxic and posthypoxic endothelial cells. Initial studies indicated that activated PMN preferentially promote endothelial barrier function in posthypoxic endothelial cells (>60% increase over normoxia). Extension of these findings identified at least one soluble mediator as extracellular adenosine triphosphate (ATP). Subsequent studies revealed that ATP is coordinately hydrolyzed to adenosine at the endothelial cell surface by hypoxia-induced CD39 and CD73 (>20-and >12-fold increase in mRNA, respectively). Studies in vitro and in cd39-null mice identified these surface ecto-enzymes as critical control points for posthypoxia-associated protection of vascular permeability. Furthermore, insight gained through microarray analysis revealed that the adenosine A2B receptor (AdoRA2B) is selectively up-regulated by hypoxia (>5-fold increase in mRNA), and that AdoRA2B antagonists effectively neutralize ATP-mediated changes in posthypoxic endothelial permeability. Taken together, these results demonstrate transcription coordination of adenine nucleotide and nucleoside signaling at the vascular interface during hypoxia.
Eastern Cooperative Oncology Group: a comparison of adjuvant doxorubicin and observation for patients with localized soft tissue sarcoma. (1987)

Forty-seven patients with stage I, II, or III soft tissue sarcoma were entered into a prospective randomized Eastern Cooperative Oncology Group (ECOG) adjuvant protocol. Eligibility included conservative or radical primary treatment for local cure. Patients were then randomized to control or Adriamycin (Adria Laboratories, Columbus, OH). Adriamycin was administered at 70 mg/m2 (slow push, every 3 weeks for seven courses for a maximum of 550 mg/m2). To date, 32 patients, 17 males and 15 females, with an age range of 17 to 75 years (median, 44 years) have been followed sufficiently long to be included in this analysis. Nine patients have died. The median follow-up of the remaining 23 patients is 30 months (range, 2 to 50 months). Survival was not significantly different between Adriamycin or control. However, the disease-free interval was slightly different in favor of observation. This preliminary report does not support the hypothesis that Adriamycin is an effective adjuvant therapy for soft tissue sarcoma. Due to the small numbers, these results must be interpreted in relation to our ability to detect a difference, if in fact one existed. These preliminary data suggest that adjuvant Adriamycin not be used outside the confines of a clinical trial such as the current intergroup adjuvant sarcoma study.
A survey of multilingual text retrieval (1996)

This report reviews the present state of the art in selection of texts in one language based on queries in another, a problem we refer to as &quot;multilingual&quot; text retrieval. Present applications of multilingual text retrieval systems are limited by the cost and complexity of developing and using the multilingual thesauri on which they are based and by the level of user training that is required to achieve satisfactory search effectiveness. A general model for multilingual text retrieval is used to review the development of the field and to describe modern production and experimental systems. The report concludes with some observations on the present state of the art and an extensive bibliography of the technical literature on multilingual text retrieval. The research reported herein was supported, in part, by Army Research Office contract DAAL03-91-C0034 through Battelle Corporation, NSF NYI IRI-9357731, Alfred P. Sloan Research Fellow Award BR3336, a General Research Board Semester A...
ChemInform Abstract: THIENO(2,3‐D)PYRIMIDINES AS POTENTIAL CHEMOTHERAPEUTIC AGENTS (1979)

Abstract Durch Methylie‐ rung von (Ia) wird (Ib) erhalten, mit POCl 3 bzw. Natriumethylat werden unter Erhitzen aus (Ia) die Derivate (IIa) bzw. (IIb) gebildet, aus (IIa) sind ferner mit Thioharnstoff das Mercaptan (IIc) und mit Aminen die Verbindungen (IId) zugänglich (X = verschieden substituierte Benzyl‐ und Phenylreste, Ausbeuten 74 ‐ 93%).
A debug probe for concurrently debugging multiple embedded cores and inter-core transactions in NoC-based systems (2008)

Existing SoC debug techniques mainly target bus-based systems. They are not readily applicable to the emerging system that use Network-on-Chip (NoC) as on-chip communication scheme. In this paper, we present the detailed design of a novel debug probe (DP) inserted between the core under debug (CUD) and the NoC. With embedded configurable triggers, delay control and timestamping mechanism, the proposed DP is very effective for inter-core transaction analysis as well as controlling embedded cores’ debug processes. Experimental results show the functionalities of the proposed DP and its area overhead.
A fuzzy decision making strategy for vertical handoffs (2008)

The main concern of the next generation of mobile networks is the integration of heterogeneous wireless technologies around an IP backbone. However this integration invokes many challenges such as mobility management and handoff decision making. Various approaches have been proposed to deal with handover decision problem, yet handoff initiation and network destination selection remain critical issues which are widely based on the traditional RSS measurements. In this paper, we propose a new fuzzy decision making approach that considers a variety of context parameters to trigger handoffs and choose an optimal network destination with respect to mobile terminal requirements and nearby network capabilities. The obtained results show that the proposed decision making approach maximize user preferences compared to the RSS based decision methods.
Sorption of Colloids, Organics, and Metals onto Gas-Water Interfaces: Transport Processes and Potential Remediation Technology (1999)

The knowledge gap on vadose zone colloid transport limits predicting contaminant transport at many DOE sites, and remains an outstanding scientific challenge. Although the process of contaminant sorption at mineral surfaces has received much recognition as a major mechanism controlling contaminant behavior in subsurface environments, virtually little attention has been given to the possibility of contaminant sorption at gas-water interfaces, a major interface in the vadose zone. Moreover, little effort has yet been advanced to optimize such interactions for the purpose of facilitating in-situ remediation. Gas-water interfaces, unlike water-solid interfaces, are mobile. Therefore, associations of contaminants with gas-water interfaces can be very important not only in subsurface contaminant distributions, but also in contaminant mobilization, and potentially in remediation. The first objective of this project was to develop a fundamental understanding of interactions between contaminants and gas-water interfaces. For surface-active molecules, surface excesses can be determined through the Gibbs equation combined with measuring changes in surface tension with respect to changes in their solution concentration. However, for surface-active colloids, surface tension changes are too small to measure. Until initiation of this research project, there were no techniques available for quantifying sorption of colloids at gas-water interfaces. The second purpose of the proposed research, based on improved understanding gained in the first phase studies, was to develop a sorptive microbubble remediation technique, using surfactant stabilized microbubbles (fine gas-bubbles, 1-15 {micro}m in diameters) for subsurface in-situ remediation.. In the saturated zone, both pump-and-treat, and air sparging remediation methods are ineffective at displacing contaminants in zones that are ''advectively inaccessible''. Stable microbubbles might be able to migrate beyond preferential flow pathways through buoyant rise. Oxygen and nutrient delivery for promoting aerobic degradation of organic contaminants, and surfactant delivery for emulsifying NAPLs are potential benefits of microbubble injection.
Resistance to Powdery Mildew from Some Small-fruited Malus Cultivars (1985)

Abstract Progenies from 48 small-fruited Malus species and cultivars were tested for heritable, high-level resistance to powdery mildew [ Podosphaera leucotricha (Ell. & Ev.) Salm.]. Six-week-old seedlings from controlled crosses and open pollination were inoculated by dusting with conidia in the greenhouse. ‘David’, ‘White Angel’, M. × robusta (Robusta 5), M. × robusta ‘Korea’, and an unnamed selection M. × robusta (24-7-7,8) all produced some seedlings in their progenies that remained free of infection after inoculation. The mode of inheritance of resistance was not clear.
Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL–positive leukemias identified by a proteomics approach (2006)

Inhibition of BCR-ABL tyrosine kinase with imatinib represents a major breakthrough in the treatment of patients with chronic myeloid leukemia (CML). However, resistance to imatinib develops frequently, particularly in late-stage disease. To identify new cellular BCR-ABL downstream targets, we analyzed differences in global protein expression in BCR-ABL-positive K562 cells treated with or without imatinib in vitro. Among the 19 proteins found to be differentially expressed, we detected the down-regulation of eukaryotic initiation factor 5A (eIF5A), a protein essential for cell proliferation. eIF5A represents the only known eukaryotic protein activated by posttranslational hypusination. Hypusination inhibitors (HIs) alone exerted an antiproliferative effect on BCR-ABL-positive and -negative leukemia cell lines in vitro. However, the synergistic dose-response relationship found for the combination of imatinib and HI was restricted to Bcr-Abl-positive cells. Furthermore, this synergistic effect was confirmed by cytotoxicity assays, cell-cycle analysis, and CFSE labeling of primary CD34+ CML cells. Specificity of this effect could be demonstrated by cotreatment of K562 cells with imatinib and siRNA against eIF5. In conclusion, through a comparative proteomics approach and further functional analysis, we identified the inhibition of eIF5A hypusination as a promising new approach for combination therapy in BCR-ABL-positive leukemias.
Bituminous sandstone deposits, Asphalt Ridge, Uinta County, Utah (1966)

Cannabinoids have been reported to have anti-inflammatory effects and reduce joint damage in animal models of arthritis. This suggests a potential therapeutic role in arthritis of this group of compounds. Cannabinoids were studied to determine whether they have direct effects on chondrocyte metabolism resulting in cartilage protection. Synthetic cannabinoids, R-(+)-Win-55,212 (Win-2) and S-(-)-Win-55,212 (Win-3) and the endocannabinoid, anandamide, were investigated on unstimulated or IL-1-stimulated nitric oxide (NO) production in bovine articular chondrocytes as well as on cartilage proteoglycan breakdown in bovine nasal cartilage explants. Win-2 significantly inhibited (P < 0.05) NO production in chondrocytes at 1-10 microM concentrations. The combined CB(1) and CB(2) cannabinoid receptor antagonists, AM281 and AM630, respectively, at 100 microM did not block this effect, but instead they potentiated it. Anandamide and Win-2 (5-50 microM) also inhibited the release of sulphated glycosaminoglycans in bovine cartilage explants. The results suggest that some cannabinoids may prevent cartilage resorption, in part, by inhibiting cytokine-induced NO production by chondrocytes and also by inhibiting proteoglycan degradation.
Genetic and molecular analysis of <i>DNA43</i> and <i>DNA52</i>: Two new cell‐cycle genes in <i>Saccharomyces cerevisiae</i> (1992)

Two Saccharomyces cerevisiae genes previously unknown to be required for DNA synthesis have been identified by screening a collection of temperature-sensitive mutants. The effects of mutations in DNA43 and DNA52 on the rate of S phase DNA synthesis were detected by monitoring DNA synthesis in synchronous populations that were obtained by isopycnic density centrifugation. dna43-1 and dna52-1 cells undergo cell-cycle arrest at the restrictive temperature (37 degrees C), exhibiting a large-budded terminal phenotype; the nuclei of arrested cells are located at the neck of the bud and have failed to undergo DNA replication. These phenotypes suggest that DNA43 and DNA52 are required for entry into or completion of S phase. DNA43 and DNA52 were cloned by their abilities to suppress the temperature-sensitive lethal phenotypes of dna43-1 and dna52-1 cells, respectively. DNA sequence analysis suggested that DNA43 and DNA52 encode proteins of 59.6 and 80.6 kDa, respectively. Both DNA43 and DNA52 are essential for viability and genetic mapping experiments indicate that they represent previously unidentified genes: DNA43 is located on chromosome IX, 32 cM distal from his5 and DNA52 is located on chromosome IV, 0.9 cM from cdc34.
IncreTable, a mixed reality tabletop game experience (2008)

IncreTable is a mixed reality tabletop game inspired by The Incredible Machine. Users can combine real and virtual game pieces in order to solve puzzles in the game. Game actions include placing virtual domino blocks with digital pens, controlling a virtual car by modifying the virtual terrain through a depth camera interface or controlling real robots to topple over real and virtual dominoes.
Packet classification using coarse-grained tuple spaces (2006)

While the problem of high performance packet classification has received a great deal of attention in recent years, the research community has yet to develop algorithmic methods that can overcome the drawbacks of TCAM-based solutions. This paper introduces a hybrid approach, which partitions the filter set into subsets that are easy to search efficiently. The partitioning strategy groups filters that are close to one another in tuple space [10], which makes it possible to use information from single field lookups to limit the number of subsets that must be searched. We can trade-off running time against space consumption by adjusting the coarseness of the tuple space partition. We find that for two-dimensional filter sets, the method finds the best-matching filter with just four hash probes while limiting the memory space expansion factor to about 2. We also introduce a novel method for Longest Prefix Matching (LPM), which we use as a component of the overall packet classification algorithm. Our LPM method uses a small amount of on-chip memory to speedup the search of an off-chip data structure, but uses significantly less on-chip memory than earlier methods based on Bloom filters.
Effects of age, ambient temperature, and heat-stable Escherichia coli enterotoxin on intestinal transit in infant mice (1979)

Some interrelationships among age, ambient temperature, intestinal transit, and enterotoxigenic Escherichia coli infection were studied in an infant mouse model. The transit of dye in the small intestine was accelerated during the response to heat-stable E. coli enterotoxin. Transit in the small intestine of normal mice accelerated with increased age (from less than 17 h to 8 days old) and accelerated with increased ambient temperature (from 25 to 37 degrees C). Transit was more rapid in the jejunum than in the ileum throughout the range of experimental conditions studied. E. coli strains that do not produce any of the pili known facilitate intestinal colonization were cleared from the small intestine more rapidly at 37 degrees C than at 25 degrees C. This clearance was thought to be due to accelerated transit at the higher temperature. In contrast, a strain of E. coli that produces K99 (pili previously shown to facilitate intestinal colonization in other species) was not cleared from the small intestine and colonized more intensively at 37 degrees C than at 25 degrees C. Intensified colonization by this strain was thought to be due to increased production of K99 at the higher temperature. It was suggested that sluggish intestinal transit may also be characteristic of the neonates of other species and be one of the factors predisposing them to intestinal colonization by enteropathogens. It was speculated that this predisposition may be enhanced if the neonates are chilled. However, the effect of ambient temperature on intestinal transit in homeothermic neonates such as pigs, calves, and humans may be different from that in mice because neonatal mice are poikilothermic.
Gender diversity in the oil and gas industry (2016)

A woman in every boardroom, secular happy holidays greetings, and Indigenous internships. These strategies are inoffensive and mostly well intentioned, but real change requires disruption. Indirect discrimination is an obstacle to true diversity and can lead to legal complications for employers. It is common for rigid practices or organisational structures to apply equally to everyone, but disproportionately affect one particular group of people. In a global industry that demands movement and flexibility from employees, what are those employees offered in return? In particular, the oil and gas industry must increase its efforts to attract and retain skilled women. The skills shortage is one indicia of a sector that has failed to change with the times. The industry needs to increase female workforce participation by challenging structural barriers, not simply with lip service to critical issues like work-life balance. The conversation should expand to include flexible work, mentorship, networking, offshore opportunities, and changes to recruitment practices. Furthermore, the next generation of women engineers is gearing up, with talent to feed into the industry from the ground level. It is time to get more women in the pipeline. Do law and practice match the rhetoric?
Poly(carbazole)-based anion-conducting materials with high performance and durability for energy conversion devices (2020)

An aryl ether-free less-phenyl adsorbing poly-carbazole-based polymer shows superior performance and durability for anion exchange membrane fuel cells and electrolyzers.
Deep Curiosity Search: Intra-Life Exploration Can Improve Performance on Challenging Deep Reinforcement Learning Problems (2018)

Traditional exploration methods in RL require agents to perform random actions to find rewards. But these approaches struggle on sparse-reward domains like Montezuma's Revenge where the probability that any random action sequence leads to reward is extremely low. Recent algorithms have performed well on such tasks by encouraging agents to visit new states or perform new actions in relation to all prior training episodes (which we call across-training novelty). But such algorithms do not consider whether an agent exhibits intra-life novelty: doing something new within the current episode, regardless of whether those behaviors have been performed in previous episodes. We hypothesize that across-training novelty might discourage agents from revisiting initially non-rewarding states that could become important stepping stones later in training. We introduce Deep Curiosity Search (DeepCS), which encourages intra-life exploration by rewarding agents for visiting as many different states as possible within each episode, and show that DeepCS matches the performance of current state-of-the-art methods on Montezuma's Revenge. We further show that DeepCS improves exploration on Amidar, Freeway, Gravitar, and Tutankham (many of which are hard exploration games). Surprisingly, DeepCS doubles A2C performance on Seaquest, a game we would not have expected to benefit from intra-life exploration because the arena is small and already easily navigated by naive exploration techniques. In one run, DeepCS achieves a maximum training score of 80,000 points on Seaquest, higher than any methods other than Ape-X. The strong performance of DeepCS on these sparse- and dense-reward tasks suggests that encouraging intra-life novelty is an interesting, new approach for improving performance in Deep RL and motivates further research into hybridizing across-training and intra-life exploration methods.
Synchronization with timing recovery loop in UHF RFID reader receivers (2010)

This paper focuses on synchronization of radio frequency identification (RFID) reader receivers, which plays a significant role for stability and efficiency of RFID systems. Performance of RFID reader suffers from a back-link-frequency variation of tags at a maximum of 22% according to widely used RFID standards. A new synchronization scheme employing timing recovery loop in RFID Reader Receivers is presented to solve the problem with less hardware cost. Simulation results give an improved performance compared with conventional schemes. The design is implemented on Xilinx Spartan-3E FPGA and function is verified on our RFID test platform.
SPL7013 Gel (VivaGel®) Retains Potent HIV-1 and HSV-2 Inhibitory Activity following Vaginal Administration in Humans (2011)

The study is registered at ClinicalTrials.gov under identifier: NCT00740584.
The Stereochemistry of Oxidation at Sulfur. Oxidation of 4-Substituted Thianes to Sulfoxides<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereochemistry of Oxidation at Sulfur. Oxidation of 4-Substituted Thianes to Sulfoxides1Carl R. Johnson and David McCants Jr.Cite this: J. Am. Chem. Soc. 1965, 87, 5, 1109–1114Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://pubs.acs.org/doi/10.1021/ja01083a030https://doi.org/10.1021/ja01083a030research-articleACS PublicationsRequest reuse permissionsArticle Views550Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts