gebhart/patrepeval huggingface dataset:
The Exiguobacteriumsibiricum 255-15 GtfC Enzyme Represents a Novel Glycoside Hydrolase 70 Subfamily of 4,6-α-Glucanotransferase Enzymes (2015)

The glycoside hydrolase 70 (GH70) family originally was established for glucansucrase enzymes found solely in lactic acid bacteria synthesizing α-glucan polysaccharides from sucrose (e.g., GtfA). In recent years, we have characterized GtfB and related Lactobacillus enzymes as 4,6-α-glucanotransferase enzymes. These GtfB-type enzymes constitute the first GH70 subfamily of enzymes that are unable to act on sucrose as a substrate but are active with maltodextrins and starch, cleave α1→4 linkages, and synthesize linear α1→6-glucan chains. The GtfB disproportionating type of activity results in the conversion of malto-oligosaccharides into isomalto/malto-polysaccharides with a relatively high percentage of α1→6 linkages. This paper reports the identification of the members of a second GH70 subfamily (designated GtfC enzymes) and the characterization of the Exiguobacterium sibiricum 255-15 GtfC enzyme, which is also inactive with sucrose and displays 4,6-α-glucanotransferase activity with malto-oligosaccharides. GtfC differs from GtfB in synthesizing isomalto/malto-oligosaccharides. Biochemically, the GtfB- and GtfC-type enzymes are related, but phylogenetically, they clearly constitute different GH70 subfamilies, displaying only 30% sequence identity. Whereas the GtfB-type enzyme largely has the same domain order as glucansucrases (with α-amylase domains A, B, and C plus domains IV and V), this GtfC-type enzyme differs in the order of these domains and completely lacks domain V. In GtfC, the sequence of conserved regions I to IV of clan GH-H is identical to that in GH13 (I-II-III-IV) but different from that in GH70 (II-III-IV-I because of a circular permutation of the (β/α)8 barrel. The GtfC 4,6-α-glucanotransferase enzymes thus represent structurally and functionally very interesting evolutionary intermediates between α-amylase and glucansucrase enzymes.
Crystal structure of diaquasuberatocobalt(II), Co(C8H12O4)(H2O)2 (2000)

The title compound was synthesized by the reaction of 0.5 g (2.90 mmol) suberic acid with an excess of fresh C0CO3 in 25 ml twice-destilled water, followed by filtrating the unreacted C0CO3. The filtrate was then maintained at 331 and rose-colored crystals formed within two days.
Scalable motion vector coding (2004)

Scalable wavelet-based video codecs using spatial-domain motion compensated temporal filtering require a quality-scalable motion vector codec to support a large range of bit rates with optimal compression efficiency. Introduced is a new prediction-based architecture for quality-scalable motion vector coding that outperforms the state-of-the-art wavelet-based techniques previously proposed in the literature.
Genipin-Cross-Linked Layer-by-Layer Assemblies: Biocompatible Microenvironments To Direct Bone Cell Fate (2014)

The design of biomimetic coatings capable of improving the osseointegration of bone biomaterials is a current challenge in the field of bone repair. Toward this end, layer-by-layer (LbL) films composed of natural components are suitable candidates. Chondroitin sulfate A (CSA), a natural glycosaminoglycan (GAG), was used as the polyanionic component because it promotes osteoblast maturation in vivo. In their native state, GAG-containing LbL films are generally cytophobic because of their low stiffness. To stiffen our CSA-based LbL films, genipin (GnP) was used as a natural cross-linking agent, which is much less cytotoxic than conventional chemical cross-linkers. GnP-cross-linked films display an original combination of microscale topography and tunable mechanical properties. Structural characterization was partly based on a novel donor/acceptor Förster resonance energy transfer (FRET) couple, namely, FITC/GnP, which is a promising approach for further inspection of any GnP-cross-linked system. GnP-cross-linked films significantly promote adhesion, proliferation, and early and late differentiation of preosteoblasts.
Malaria Prophylaxis: A Comprehensive Review (2010)

The flow of international travellers to and from malaria-endemic areas, especially Africa, has increased in recent years. Apart from the very high morbidity and mortality burden imposed on malaria-endemic areas, imported malaria is the main cause of fever possibly causing severe disease and death in travellers coming from tropical and subtropical areas, particularly Sub-Saharan Africa. The importance of behavioural preventive measures (bed nets, repellents, etc.), adequate chemoprophylaxis and, in selected circumstances, stand-by emergency treatment may not be overemphasized. However, no prophylactic regimen may offer complete protection. Expert advice is needed to tailor prophylactic advice according to traveller (age, baseline clinical conditions, etc.) and travel (destination, season, etc.) characteristics in order to reduce malaria risk.
EFFECTS OF MICROCRACK OF SURFACE LAYER CONCRETE ON SURFACE ABSORPTION AND SURFACE PERMEABILITY (2009)

コンクリート構造物の耐久性に大きく影響を及ぼす表層品質のうち、表面吸水抵抗性と表面透気抵抗性について検討した。実構造物での計測結果を示し、両抵抗性の相関を示した。表層のマイクロクラックが両抵抗性に悪影響を及ぼす可能性を見出し、実構造物の柱を模擬した試験体によりその影響を分析した。表面吸水については、マイクロクラックの存在により吸水抵抗性が顕著に低下し、シラン系表面含浸材の塗布により大幅に改善されることを示した。表面透気については、マイクロクラックの存在と鉄筋配置が影響し、表面透気試験から得られる透気抵抗性が実際よりも過小に評価される可能性があることを指摘した。
Daidzein and genistein contents of vegetables (2000)

Food samples (n 114) were prepared from vegetables commonly eaten in Europe. The glycosidic forms of the phyto-oestrogens daidzein and genistein were extracted from the dried foods into aqueous methanol. The isoflavones were quantified by GC-MS after hydrolytic removal of any conjugated carbohydrate. Completeness of extraction and any procedural losses of the isoflavones were accounted for using synthetic daidzin (7-O-glucosyl-4'-hydroxyisoflavone) and genistin (7-O-glucosyl-4'5-dihydroxyisoflavone) as internal standards. Of the 114 foods assayed, at a limit of quantification of 0.1 microg/kg dry weight, forty-eight contained no detectable daidzein or genistein, forty-one contained less than 100 microg/kg of the two isoflavones combined and the remaining twenty-five contained more than this amount. Soyabean products contained between 470 and 1420 mg (average of 960 mg) daidzein and genistein combined per kg wet weight of food, and legumes contained between 20 and 5750 microg/kg wet weight of food, with an average of 620 microg/kg. Cooking by boiling in water caused a decrease in the daidzein and genistein content of food in twenty-four of twenty-eight foods. The extent of the decrease was variable and warrants further investigation. The present paper comprises the first comprehensive description of the content of daidzein and genistein in vegetables.
Synthesis of well‐defined macromonomers and comb copolymers from polymers made by atom transfer radical polymerization (2003)

Abstract Poly( n ‐butyl acrylate) macromonomers with predetermined molecular weights (1300 < number‐average molecular weight < 23,000) and low polydispersity indices (<1.2) were synthesized from bromine‐terminated atom transfer radical polymerization polymers via end‐group substitution with acrylic acid and methacrylic acid. These macromonomers, having a high degree of end‐group functionalization (>90%), were radically homopolymerized to obtain comb polymers. A high macromonomer concentration, combined with a low radical flux, was needed to obtain a high conversion of the macromonomers and a reasonable degree of polymerization. By the traditional radical copolymerization of the hydrophobic macromonomers with the hydrophilic monomer N , N ‐dimethylaminoethyl methacrylate (DMAEMA), amphiphilic comb copolymers were obtained. The conversions of the macromonomers and comonomer were almost quantitative under optimized reaction conditions. The molecular weights were high (number‐average molecular weight ≈70,000), and the molecular weight distribution was broad (polydispersity index ≈ 3.5). Kinetic measurements showed simultaneous decreases in the macromonomer and DMAEMA concentrations, indicating a relatively homogeneous composition of the comb copolymers over the whole molecular weight range. This was supported by preparative size exclusion chromatography. The copolymerization of poly( n ‐butyl acrylate) macromonomers with other hydrophilic monomers such as acrylic acid or N , N ‐dimethylacrylamide gave comb copolymers with multimodal molecular weight distributions in size exclusion chromatography and extremely high apparent molecular weights. Dynamic light scattering showed a heterogeneous composition consisting of small (6–9 nm) and large (23–143 nm) particles, probably micelles or other type of aggregates. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 3425–3439, 2003
Fish Consumption and Risk of Stroke in Men (2002)

Our findings suggest that eating fish once per month or more can reduce the risk of ischemic stroke in men.
Helicobacter pylori occurrence and transmission: A family affair? (2006)

About half of the world's population is estimated to be infected with Helicobacter pylori, a gastric bacterium that contributes to the development of peptic ulcer disease and gastric cancer. H. pylori is more prevalent in low-income areas of the world and social and economic development decreases the prevalence as reflected in comparisons both within and between countries. The infection is typically acquired in early childhood and once established commonly persists throughout life unless treated. Person-to-person transmission within the family appears to be the predominant mode of transmission, particularly from mothers to children and among siblings, indicating that intimate contact is important. The route of transmission is uncertain, but the gastro-oral, oral-oral and faecal-oral routes are likely possibilities. Hence, gastroenteritis may facilitate dissemination of the infection. The community and environment may play additional roles for H. pylori transmission in some (low-income) settings. Furthermore, host and bacterial factors may modify the probabilities of acquisition and persistence of the infection. The understanding of H. pylori occurrence and transmission is of practical importance if future study deems prevention of the infection desirable in some high-prevalence populations. The present paper reviews aspects of H. pylori occurrence and transmission with an emphasis on household factors.
An FPGA based Accelerator for Encrypted File Systems (2011)

In this work, the possibility of application of an AES coprocessor to increase the performance of encrypted file systems is examined. A brief description of an architecture based on an FPGA connected to a GPPU using PCI Express is followed by the preliminary evaluation of its performance compared to a software-only solution, as well as a discussion of bottlenecks and ways to deal with them.
Study on Maneuvering Target Tracking Algorithm Based on Variable Structure Multiple-Model (2012)

According to the problem of fixed structure multiple-model algorithm used in multiple-model maneuvering target tracking,that is using a few models to match the real situation of sports is difficult but increasing the number of models will cause the competition between them,a new multiple-model algorithm based on variable structure is proposed.This algorithm adopts CV model, CS model and CT model for interaction,and realizes the adaptive of model sets by adjusting the maneuvering frequency parameter and the angular acceleration in real-time.The simulation result shows that this algorithm in terms of the accuracy of tracking is superior to the fixed structure multiple-model algorithm for all the non-maneuvering,maneuvering turn and straight-line maneuvering targets.
ChemInform Abstract: A Highly Efficient and Selective Turn‐on Fluorescent Sensor for Cu<sup>2+</sup> Ion. (2010)

Abstract A new fluorescent chemosensor (I) based on an open‐chain azacrown bearing a quinoline moiety is synthesized in a four‐step procedure starting from 2‐nitrophenol.
Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner (2012)

These results indicate that cedrol stimulates ECM production, with possible applications to the maintenance of skin texture.
Geochemistry of formation waters from the Wolfcamp and “Cline” shales: Insights into brine origin, reservoir connectivity, and fluid flow in the Permian Basin, USA (2016)

Despite being one of the most important oil producing provinces in the United States, information on basinal hydrogeology and fluid flow in the Permian Basin of Texas and New Mexico is lacking. The source and geochemistry of brines from the basin were investigated (Ordovician- to Guadalupian-age reservoirs) by combining previously published data from conventional reservoirs with geochemical results for 39 new produced water samples, with a focus on those from shales. Salinity of the Ca–Cl-type brines in the basin generally increases with depth reaching a maximum in Devonian (median = 154 g/L) reservoirs, followed by decreases in salinity in the Silurian (median = 77 g/L) and Ordovician (median = 70 g/L) reservoirs. Isotopic data for B, O, H, and Sr and ion chemistry indicate three major types of water. Lower salinity fluids (< 70 g/L) of meteoric origin in the middle and upper Permian hydrocarbon reservoirs (1.2–2.5 km depth; Guadalupian and Leonardian age) likely represent meteoric waters that infiltrated through and dissolved halite and anhydrite in the overlying evaporite layer. Saline (> 100 g/L), isotopically heavy (O and H) water in Leonardian [Permian] to Pennsylvanian reservoirs (2–3.2 km depth) is evaporated, Late Permian seawater. Water from the Permian Wolfcamp and Pennsylvanian “Cline” shales, which are isotopically similar but lower in salinity and enriched in alkalis, appear to have developed their composition due to post-illitization diffusion into the shales. Samples from the “Cline” shale are further enriched with NH4, Br, I and isotopically light B, sourced from the breakdown of marine kerogen in the unit. Lower salinity waters (< 100 g/L) in Devonian and deeper reservoirs (> 3 km depth), which plot near the modern local meteoric water line, are distinct from the water in overlying reservoirs. We propose that these deep meteoric waters are part of a newly identified hydrogeologic unit: the Deep Basin Meteoric Aquifer System. Chemical, isotopic, and pressure data suggest that despite over-pressuring in the Wolfcamp shale, there is little potential for vertical fluid migration to the surface environment via natural conduits.
Distributed Dynamic Hash Tables Using IBM LAPI (2002)

An asynchronous communication library for accessing and managing dynamic hash tables over a network of Symmetric Multiprocessors (SMP) is presented. A blocking factor is shown experimentally to reduce the variance of the wall clock time. It is also shown that remote accesses to a distributed hash table can be as effective and scalable as the one-sided operations of the low-level communication middleware on an IBM SP.
Dihydroxythiophenes Are Novel Potent Inhibitors of Human Immunodeficiency Virus Integrase with a Diketo Acid-Like Pharmacophore (2006)

We have identified dihydroxythiophenes (DHT) as a novel series of human immunodeficiency virus type 1 (HIV-1) integrase inhibitors with broad antiviral activities against different HIV isolates in vitro. DHT were discovered in a biochemical integrase high-throughput screen searching for inhibitors of the strand transfer reaction of HIV-1 integrase. DHT are selective inhibitors of integrase that do not interfere with virus entry, as shown by the inhibition of a vesicular stomatitis virus G-pseudotyped retroviral system. Moreover, in quantitative real-time PCR experiments, no effect on the synthesis of viral cDNA could be detected but rather an increase in the accumulation of 2-long-terminal-repeat cycles was detected. This suggests that the integration of viral cDNA is blocked. Molecular modeling and the structure activity relationship of DHT demonstrate that our compound fits into a two-metal-binding motif that has been suggested as the essential pharmacophore for diketo acid (DKA)-like strand transfer inhibitors (Grobler et al., Proc. Natl. Acad. Sci. USA 99:6661-6666, 2002.). This notion is supported by the profiling of DHT on retroviral vectors carrying published resistance mutations for DKA-like inhibitors where DHT showed partial cross-resistance. This suggests that DHT bind to a common site in the catalytic center of integrase, albeit with an altered binding mode. Taken together, our findings indicate that DHT are novel selective strand transfer inhibitors of integrase with a pharmacophore homologous to DKA-like inhibitors.
An Expert System Approach To Palletizing Unequal-Sized Containers (1989)

This interim report describes an expert system prototype being developed to palletize boxes of unequal sizes. Finding feasible arrangements for boxes of various sizes is an important problem, particularly for distribution centers. Previous efforts have focused on palletizing equal size boxes, or on the problem of unequal size containers where the inequalities are only in two dimensions. Though useful starting points, both approaches are overly restrictive in their scope. This report describes an expert system prototype being developed at Georgia Tech that integrates domain heuristics with packing algorithms to produce optimal packing configurations. As the nature of the palletizing problem varies for each distribution center, the expert system uses several application-specific assumptions to tailor the system to a specific pallet packing approach. Results demonstrating optimal palletizing for column stacking domains are presented and future plans are outlined.
Serum thymidine kinase 1 reflects the progression of pre-malignant and malignant tumors during therapy (2008)

This study evaluated the clinical utility of serum thymidine kinase 1 (STK1) in following the progression of pre-malignancies and malignancies and in monitoring the response of common carcinomas to therapy within a routine clinical setting. The STK1 concentration levels of patients with malignancies (n=224), pre-malignancies (n=10), non-tumor/non-proliferating diseases (systemic lupus erythematosus, SLE) (n=53), benign tumors (n=20) and healthy volunteers (n=761) were determined by enhanced chemoluminescence dot blot assay. Prior to treatment, STK1 levels in the pre-malignant group alone (3.1±2.3) or in the pre-malignant and malignant groups together (2.3±1.9) were significantly higher than in the benign (1.4±0.8), SLE (1.1±0.8) or healthy volunteer (0.6±0.4) groups (p<0.01). According to ROC analysis, the STK1 assay provided a high degree of discrimination between STK1-positive pre-malignant (0.978) or pre-malignant + malignant (0.941) patients and STK1-negative healthy individuals. After varying treatments (surgery, chemotherapy, X-ray), STK1 levels increased by 40-50% during the first month, then decreased back to normal values or even lower. Following treatment, STK1 levels were significantly increased in squamous cell carcinoma (SCC) as compared to adenocarcinoma (AC) patients. In other types of malignancies, STK1 levels decreased from as early as the first month. The STK1 levels of relapsed treated patients were significantly higher (50-60%) than those of mid/long-term treated patients. In conclusion, the STK1 assay discriminated between patients with malignancies and healthy individuals very well, and is therefore potentially useful for a broad range of clinical applications. For example, it could be used for the evaluation of early tumor progression or of tumor progression during therapy in routine clinical settings, as well as for the screening of healthy individuals.
The Mathematical and Military Works of Thomas Digges, with an Accunt of His Life (1945)

Research Article| December 01 1945 The Mathematical and Military Works of Thomas Digges, with an Accunt of His Life Henry J. Webb Henry J. Webb Search for other works by this author on: This Site Google Modern Language Quarterly (1945) 6 (4): 389–400. https://doi.org/10.1215/00267929-6-4-389 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Henry J. Webb; The Mathematical and Military Works of Thomas Digges, with an Accunt of His Life. Modern Language Quarterly 1 December 1945; 6 (4): 389–400. doi: https://doi.org/10.1215/00267929-6-4-389 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsModern Language Quarterly Search Advanced Search The text of this article is only available as a PDF. Copyright © 1945 by Duke University Press1945 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
An Enhanced Device Localization Approach Using Mutual Signal Strength in Cellular Networks (2015)

This study proposes an accurate and calibration-free mobile device localization algorithm in cellular networks. By exploiting the mutual received signal strength (RSS) between base stations, the proposed algorithm creates an accurate RSS-distance mapping using multivariable regression approaches. Unlike traditional methods, the generated mapping is not fixed but rather dynamic to reflect current environments, thus, better characterizing the RSS-distance relationship in the target area and achieving more accurate location estimations without additional calibration effort. Furthermore, this study adopts singular value decomposition to enhance the robustness of our system. Experiments were conducted in a realistic GSM network. Results demonstrated that our approach apparently improves the positioning accuracy, as compared to three existing cellular-based methods, Cell-ID, enhanced Cell-ID, and propagation-model approaches.
Methods of repairing and altering dentures (2010)

Dentists can usually repair cracked or fractured dentures, strengthen dentures and remove stains. They can also repair chips in the artificial teeth or replace ones that have fallen out. This article will explain why some dentures are repaired or amended and how this is achieved.
Mass transfer to a rotating fluid. Part II. Transport from the base of an agitated cylindrical tank (1972)

Abstract Mass transfer to the base of an unbaffled cylindrical tank which is agitated by an axially‐mounted impeller is studied experimentally and theoretically. Measured local mass transfer coefficients vary with radial position and fall within theoretical bounds derived for the case of a fluid undergoing solid body rotation above the boundary layer on the base. Average mass transfer coefficients and torque delivered to the base are fitted by consistent theoretical expressions, and an empirical correlation is developed for calculating the average liquid phase mass transfer coefficient.
Structural requirements for biological activity among antileukemic glaucarubolone ester quassinoids (1976)

A C-15 ester substituent is required for significant antileukemic activity among the glaucarubolone ester quassinoids, and variations in the ester group are not accompanied by particularly marked changes in antileukemic activity. Unsaturation at the 3,4 position is advantageous for optimal activity, and hydrogenation of this double bond results in marked diminution in both cytotoxicity toward KB cells in tissue culture and inhibitory activity against the P-388 lymphocytic leukemia in mice.