gebhart/patrepeval huggingface dataset:
Folate-Conjugated Thermoresponsive Block Copolymers: Highly Efficient Conjugation and Solution Self-Assembly (2008)

A combination of controlled radical polymerization and azide-alkyne click chemistry was employed to prepare temperature-responsive block copolymer micelles conjugated with biological ligands with potential for active targeting of cancer tissues. Block copolymers of N-isopropylacrylamide (NIPAM) and N,N-dimethylacrylamide (DMA) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with an azido chain transfer agent (CTA). Pseudo-first-order kinetics and linear molecular weight dependence on conversion were observed for the RAFT polymerizations. CuI-catalyzed coupling with propargyl folate resulted in folic acid residues being efficiently conjugated to the alpha-azido chain ends of the homo and block copolymers. Temperature-induced self-assembly resulted in aggregates capable of controlled release of a model hydrophobic drug. CuI-catalyzed azide-alkyne cycloaddition has proven superior to conventional methods for conjugation of biological ligands to macromolecules, and the general strategy presented herein can potentially be extended to the preparation of folate-functionalized assemblies with other stimuli susceptibility (e.g., pH) for therapeutic and imaging applications.
The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales). (1983)

From the culture supernatant of the myxobacterium, Myxococcus fulvus strain Mx f50, an antibiotic activity was isolated which blocked growth of many Gram-positive and several Gram-negative bacteria, but not of yeasts and fungi. The activity consisted of two closely related compounds, myxopyronins A and B. The myxopyronins appear to be new antibiotics, and seem to specifically inhibit bacterial RNA polymerase.
Improvement in the Instrumentation for Partial Discharge Location in Cables (1985)

An instrument for detecting and locating partial discharges on power cables has been developed. This paper describes some recent improvements that have been incorporated. It also presents new experimental data which show that low level discharges on cables the length of full reels can be located. Documentation is also included which shows that it is possible to locate each of more than one simultaneously operating sources of noise on a cable.
Novel reactive compatibilization strategy on immiscible polypropylene and polystyrene blend (2007)

Abstract Polypropylene (PP) and polystyrene (PS) are immiscible and incompatible. Since both PP and PS components possess no reactive functional group, reactive compatibilization of a PP/PS blend is impossible unless certain reactive functional groups are imparted to either PP or PS. In this study we provide a simple approach to reactively compatibilize the nonreactive PP/PS blend system by physically functionalizing PP and PS with the addition of maleic anhydride grafted PP (PP‐ g ‐MA) and styrene maleic anhydride random copolymer (SMA), respectively. An epoxy monomer, serving as a coupler and possessing four epoxy groups able to react with the maleic anhydride of PP‐ g ‐MA and SMA, was then added during melt blending. Observations of the finer PS domain sizes and improved mechanical properties support the plausibility of reactive compatibilization of this nonreactive PP/PS blend by combining physically functionalized PP and PS with tetra‐glycidyl ether of diphenyl diamino methane (TGDDM) in a one‐step extrusion process. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2008
Synthesis and Ruthenium‐Catalyzed Enantioselective Hydrogenation of 3‐<i>O</i>‐Substituted 1,3‐Dihydroxypropan‐2‐ones. Part 2 (1993)

Abstract A number of 3‐ O ‐substituted 1,3‐dihydroxypropan‐2‐ones have been synthesized in view of their potential use as prochiral precursors of optically active glycerols. Indeed, the oxo‐ethers have been reduced to the corresponding 3‐ O ‐substituted glycerols via chiral Ru complexes derived from ( S )‐binap, ( =(−)‐( S )‐2,2′‐bis(diphenylphosphino)‐1,1′‐binaphthalene) with enantiomeric excesses up to 93%. The steric course of the catalytic reduction appears to be essentially dependent on the steric encumbrance of the substituents; indeed, a dramatic increase of the enantiomeric excess is observed when the bulky trityl group is substituted by the less encumbering benzyl or octadecyl groups.
Bacteria‐induced protein P4 (hemolin) from <i>Manduca sexta</i>: A member of the immunoglobulin superfamily which can inhibit hemocyte aggregation (1991)

The synthesis of a number of hemolymph proteins is induced in insects in response to bacterial infections. The major induced hemolymph protein in larvae of Manduca sexta is a glycoprotein of Mr = 48,000 known as P4. We have isolated a clone for P4 from a fat body cDNA library constructed from RNA isolated from larvae injected with bacteria. The cDNA has an open reading frame encoding a 411 residue polypeptide with a hydrophobic NH2-terminal sequence, which appears to be a signal peptide. Analysis of the deduced amino acid sequence shows that P4 is a member of the immunoglobulin (Ig) gene superfamily, and is composed largely of four C2 type Ig domains. The M. sexta P4 amino acid sequence is 60% identical with hemolin (P4) from Hyalophora cecropia. The name "hemolin" has also been adopted for the M. sexta P4 protein. Hemolin mRNA levels in fat body begin to increase within 1 h after injection of bacteria into fifth instar larvae and within 4 h after injection of adults. Hemolin associates with the surface of hemocytes and inhibits hemocyte aggregation responses, suggesting a role for the protein in modulating hemocyte adhesion during recognition and response to bacterial infections in insects.
Effect of thymopoietin pentapeptide (TP5) on autoimmunity. I. TP5 suppression of induced erythrocyte autoantibodies in C3H mice. (1980)

C3H mice (young and old), when immunized with the cross-reacting rat erythrocytes, produced erythrocyte autoantibodies that usually persisted for more than 10 weeks. I.P. injection of thymopoietin pentapeptide (TP5) once or thrice weekly accelerated the loss of erythrocyte autoantibodies 7 weeks after immunization; 10 ng of TP5 was the optimal dose. The rat agglutinin responses of these immunized mice were unaffected by TP5 during the whole period of study. Spleen cells from rat erythrocyte-immunized mice, when transferred to syngeneic recipients undergoing similar immunization schedules, delayed the appearance of erythrocyte autoantibodies in the recipients. A greater delay was observed when spleen cells were taken from mice that had also received TP5 treatment.
Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for the Management of Peritoneal Carcinomatosis From Colorectal Cancer: A Multi-Institutional Study (2004)

The therapeutic approach combining cytoreductive surgery with perioperative intraperitoneal chemotherapy achieved long-term survival in a selected group of patients with PC from colorectal origin with acceptable morbidity and mortality. The complete cytoreductive surgery was the most important prognostic indicator.
Managing pages in shared virtual memory systems (1993)

In large-scale multiprocessors, whether loosely or tightly coupled, some memory is cheaper to access than other memory. Because direct management of memory on these machines is quite burdensome to the programmer, much research effort has been directed toward providing a shared virtual memory (SVM) interface. Clearly, the success of this endeavor depends heavily on the efficiency of page management strategies. To date, this has been primarily the responsibility of the operating system, and secondarily that of the hardware. Unfortunately, delaying page management decisions entirely until run time can lead to an unacceptable loss of efficiency, due to poor data layout and memory reference patterns that are fixed by the end of compile time. For this reason, programmer assistance has been occasionally solicited. However, this disrupts the SVM abstraction. Moreover, many of these problems may be addressable at the compiler level instead. This is especially promising for array-based languages where compiler-based, analytical technology is most mature. Surprisingly, this possibility is largely unexplored. In this paper, we discuss the issue of compiler involvement in areas ranging from loop transformations and scheduling issues, to data layout strategies, page placement decisions, access pattern analysis, and use of run time system directives.
DNA Sequence Alignment by Window based Optical Correlator (2017)

In genomics, pattern matching against a sequence of nucleotides plays a pivotal role for DNA sequence alignment and comparing genomes. This helps tackling some diseases, such as cancer in humans. The complexity of searching biological sequences in big databases has transformed sequence alignment problem into a challenging field of research in bioinformatics. A large number of research has been carried to solve this problem based on electronic computers. The required extensive amount of computations for handling this huge database in electronic computers leads to vast amounts of energy consumption for electrical processing and cooling. On the other hand, optical processing due to its parallel nature is much faster than electrical counterpart at a fraction of energy consumption level and cost. In this paper, an algorithm based on optical parallel processing is proposed that not only locate similarity between sequences but also determines the exact location of edits. The proposed algorithm is based on partitioning the read sequence into some parts, namely, windows, then, computing their correlation with reference sequence in parallel. Multiple metamaterial based optical correlators are used in parallel to optically implement the architecture. Design limitations and challenges of the architecture are also discussed in details. The simulation results, comparing with the well-known BLAST algorithm, demonstrate superior speed, accuracy, and much lower power consumption.
Validation and Development of HPTLC Method for Simultaneous Estimation of Apigenin and Luteolin in Selected Marketed Ayurvedic Formulations of ‘Dashmula’ and in Ethyl Acetate Extract of Premna integrifolia L. (2017)

Dashmula are specific ayurvedic combination of ten roots used for various disorders of liver, kidney, uterus. Standardisation of herbals are necessity for efficacy and quality parameter as per WHO guidelines. Therefore, through this original research attempt was made to standardise one of ‘Dashmula’, P. integrifolia and selected batches of marketed formulation using Apigenin and Luteolin as active biological marker for simultaneous quantification and fingerprinting through developed and validated HPTLC techniques. Developed mobile phase Toluene: Ethyl acetate: Formic acid (6:4:0.15) gave Rf (Retention factor) 0.39 and 0.29 for Standard Apigenin and Luteolin respectively at 347 nm iso absorptive wavelength. The ethyl acetate extract of P. integrifolia (PI-ET), ‘Dashmularishtha’: Manufactuer 1; 3 coded batches as DF1, DF2, DF3, Manufacturer 2; 3 coded batches -as BF4, BF5, BF6, ‘Dashmulkadha’: Manufacturer 3; 3 coded batches as KF, KF8, KF9 were found to contain : 12.8% w/w, 0.294 mg/ml%, 0.429 mg/ ml%, 0.314 mg/ml%, 0.077 mg/ml%, 0.071 mg/ml%, 0.145 mg/ml%, 0.176 mg/ml%, 0.242 mg/ml%, 0.098 mg/ml% of Apigenin and 4.7% w/w, 0.542 mg/ml%, 0.365 mg/ml%, 0.569 mg/ml%, 0.343 mg/ml%, 0.311 mg/ml%, 0.607 mg/ ml%, 0.812 mg/ml%, 0.828 mg/ml%, 0.439 mg/ml% of Luteolin respectively. In stem powder of P. integrifolia 19.84 mg/gm% Apigenin and 7.433 mg/gm% Luteolin was calculated. The estimation shows variance in manufacturers and even within batches, but will be quality control parameter. The method was validated for specificity, linearity, accuracy, precision, and robustness. It was found to be linear in range of 40-120 ng/band with regression coefficient 0.9983, 0.9997 for Apigenin and luteolin. Percentage recovery study carried out for extract PI-ET and DF1 with spike of Apigenin and Luteolin at 80, 100 and 120% level, carried out for inter and intraday precision, subjected for one way ANOVA and found F value is below tabulated F(2,6) value 5.14, therefore there is no significance variance of obtained values.
Introduction to Probability (2014)

Developed from celebrated Harvard statistics lectures, Introduction to Probability provides essential language and tools for understanding statistics, randomness, and uncertainty. The book explores a wide variety of applications and examples, ranging from coincidences and paradoxes to Google PageRank and Markov chain Monte Carlo (MCMC). Additional
Wireless USB-Based Home Security System on The OSGi Service Platform (2007)

This paper presents the design of a wireless USB home controller and a home security system using it, and shows the binding algorithm of the wireless USB network, the implementation of wireless USB device access classes on the OSGi service platform and a home security system as an application.
Neural algorithms of data performing in finite fields GF(2/sup m/) (1992)

Neural networks realizing finite-field arithmetic are presented. The neural algorithms of addition and multiplication are exploited to develop a neural network realizing Zhegalkin's polynomial of the Boolean function. Neural algorithms for addition and exponentiation computation were used for solving linear equation systems and for evaluating logarithms in finite fields. The author presents the operations' run-time expressions in finite fields with neural networks and a comparative estimation of existing multiplication and exponentiation algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Simulation of Grover's quantum search algorithm in an Ising-nuclear-spin-chain quantum computer with first- and second-nearest-neighbour couplings (2008)

We implement Grover's quantum search algorithm on a nuclear spin chain quantum computer, taking into Ising type interactions between nearest and second nearest neighbours into account. The performance of the realisation of the algorithm is studied by numerical simulations with four spins. We determine the temporal behaviour of the fidelity during the algorithm, and we compute the final fidelity as a function of the Rabi frequency. For the latter, we obtained pronounced maxima at frequencies which fulfil the condition of the (2\pi k)-method with respect to the second nearest neighbour interactions.
Possibilities of 40 Gb/in/sup 2/ perpendicular recording (2005)

Summary form only given. The complete presentation was not made available for publication as part of the conference proceedings.
Maser Theory: Old Problems and New Insights (2017)

Abstract Maser theory continues to be driven by advances in observational techniques. Here, I consider the responses to VLBI with space-Earth baselines and cross-correlation spectroscopy (a re-consideration of coherence properties), routine observation in full-Stokes polarization (a re-casting of the polarization transfer equations), and long-term variability monitoring (3-D modelling of irregular domains).
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome (2003)

The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 ( TLR4 ) Asp-299-->Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P =0.076), suggesting a role for TLR4 signalling in the severity of SIRS.
Initial magnetization, remanence, and coercivity of the random anisotropy amorphous ferromagnet (1977)

We analyze the coercivity, remanence, and initial magnetization of a single-domain, single-component amorphous material. We assume a uniform ferromagnetic exchange and concentrate on the effect of single-ion anisotropy. We find a threshold anisotropy below which the coercivity is zero. At large anisotropy, the coercivity is proportional to the anisotropy energy. Exchange pulling increases the remanence of amorphous materials. We suggest that exchange pulling between crystallites may also be operative in small-grain metallic polycrystals.
Recombination between chromosomal IS200 elements supports frequent duplication formation in Salmonella typhimurium. (1995)

Spontaneous tandem chromosomal duplications are common in populations of Escherichia coli and Salmonella typhimurium. They range in frequency for a given locus from 10(-2) to 10(-4) and probably form by RecA-dependent unequal sister strand exchanges between repetitive sequences in direct order. Certain duplications have been observed previously to confer a growth advantage under specific selective conditions. Tandem chromosomal duplications are unstable and are lost at high frequencies, representing a readily reversible source of genomic variation. Six copies of a small mobile genetic element IS200 are evenly distributed around the chromosome of S. typhimurium strain LT2. A survey of 120 independent chromosomal duplications (20 for each of six loci) revealed that recombination between IS200 elements accounted for the majority of the duplications isolated for three of the loci tested. Duplications of the his operon were almost exclusively due to recombination between repeated IS200 elements. These data add further support to the idea that mobile genetic elements provide sequence repeats that play an important role in recombinational chromosome rearrangements, which may contribute to adaptation of bacteria to stressful conditions.
Improvement of the Voltage Difference Method to Detect Arcing Faults Within Unfused Grounded-Wye 22.9-kV Shunt Capacitor Bank (2007)

This paper presents an effective algorithm to protect unfused 22.9-kV shunt capacitor banks in grounded-wye connection by improving an existing voltage difference method-based algorithm. It has often been reported that it is difficult to detect ground faults with arc near the input points within the bank using existing algorithms that use only the magnitude of the differential voltage. In this paper, it is shown that ground faults with arc near the input point can be detected by fast Fourier transform (FFT) analysis of the differential voltage and that the proposed algorithm is not impacted by harmonics generated by nonlinear loads which have quantitative influence on the capacitor banks. Consequently, the proposed method using harmonics analysis can be applied as an extended version of the existing detection method. The proposed method is applied to a simplified 22.9-kV real-life Korea Electric Power Corporation system and it is verified that the proposed algorithm can clearly detect faults that are not easily detected by the existing method
A-kinase anchoring proteins: scaffolding proteins in the heart (2011)

The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of cAMP effectors and regulatory enzymes provides the architectural infrastructure for the specialization of the cAMP signaling network. Scaffolds that bind protein kinase A are called "A-kinase anchoring proteins" (AKAPs). In this review, we discuss recent advances in our understanding of how PKA is compartmentalized within the cardiac myocyte by AKAPs and how AKAP complexes modulate cardiac function in both health and disease.
HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [<sup>99m</sup>Tc(CO)<sub>3</sub>]<sup>+</sup>, and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation (2010)

Affibody molecules are a class of small (ca. 7 kDa) robust scaffold proteins suitable for radionuclide molecular imaging of therapeutic targets in vivo. A hexahistidine tag at the N-terminus streamlines development of new imaging probes by enabling facile purification using immobilized metal ion affinity chromatography (IMAC), as well as convenient [⁹⁹(m)Tc(CO)₃](+)-labeling. However, previous studies in mice have demonstrated that Affibody molecules labeled by this method yield higher liver accumulation of radioactivity, compared to the same tracer lacking the hexahistidine tag and labeled by an alternative method. Two variants of the HER2-binding Affibody molecule Z(HER)₂(:)₃₄₂ were made in an attempt to create a tagged tracer that could be purified by immobilized metal affinity chromatography, yet would not result in anomalous hepatic radioactivity accumulation following labeling with [⁹⁹(m)Tc(CO)₃](+). In one construct, the hexahistidine tag was moved to the C-terminus. In the other construct, every second histidine residue in the hexahistidine tag was replaced by the more hydrophilic glutamate, resulting in a HEHEHE-tag. Both variants, denoted Z(HER)₂(:)₃₄₂-H₆ and (HE)₃-Z(HER)₂(:)₃₄₂, respectively, could be efficiently purified using IMAC and stably labeled with [⁹⁹(m)Tc(CO)₃](+) and were subsequently compared with the parental H₆-Z(HER)₂(:)₃₄₂ having an N-terminal hexahistidine tag. All three variants were demonstrated to specifically bind to HER2-expressing cells in vitro. The hepatic accumulation of radioactivity in a murine model was 2-fold lower with [⁹⁹(m)Tc(CO)₃](+)-Z(HER2:342)-H₆ compared to [⁹⁹(m)Tc(CO)₃](+)-H₆-Z(HER)₂(:)₃₄₂, and more than 10-fold lower with [⁹⁹(m)Tc(CO)₃](+)-(HE)₃-Z(HER)₂(:)₃₄₂. These differences translated into appreciably superior tumor-to-liver ratio for [⁹⁹(m)Tc(CO)₃](+)-(HE)₃-Z(HER)₂(:)₃₄₂ compared to the alternative conjugates. This information might be useful for development of other scaffold-based molecular imaging probes.
Shoulder involvement in rheumatic diseases. Sonographic findings. (1999)

Shoulder sonography showed involvement of all structures in RA, the prevalence of effusion in PMR, and involvement mainly of tendons in PD.
A Preservative For Urine Specimens In Transit To The Bacteriological Laboratory (1971)

SUMMARY Bacteriological examination of the urine is often rendered useless by overgrowth of organisms, which occurs while the specimen is in transit from clinic to laboratory. A delay of 4 hr at room temperature is often sufficient to produce a 100-fold increase in the viable bacterial count. It is shown that this overgrowth can be prevented by adding to the freshly collected urine a mixed solution of NaCl and polyvinylpyrrolidone to give final concentrations of 9.0 per cent. NaCl and 1.0 per cent. PVP. By this means it is possible to perform quantitative bacteriological tests on mid-stream specimens that have been delayed in transit for 24 hr or longer.
Pseudaboydins A and B: Novel Isobenzofuranone Derivatives from Marine Fungus Pseudallescheria boydii Associated with Starfish Acanthaster planci (2014)

Two novel isobenzofuranone derivatives, pseudaboydins A (1) and B (2), along with five known compounds, including (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-hydroxybenzofuran (3), (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-methoxybenzofuran (4), 3,3'-dihydroxy-5,5'-dimethyldiphenyl ether (5), 3-(3-methoxy-5-methylphenoxy)-5-methylphenol (6) and (-)-regiolone (7), were isolated from the culture broth of the marine fungus, Pseudallescheria boydii, associated with the starfish, Acanthaster planci. Their structures were elucidated primarily based on NMR and MS data. The absolute configurations of 1-4 were determined by CD spectroscopy and single-crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of 1-4 were evaluated. Pseudaboydin A (1) showed moderate cytotoxic activity against human nasopharyngeal carcinoma cell line HONE1, human nasopharyngeal carcinoma cell line SUNE1 and human glandular lung cancer cell line GLC82 with IC50 values of 37.1, 46.5 and 87.2 μM, respectively.