gebhart/patrepeval huggingface dataset:
Resource Scheduling for OFDMA/TDD Based Relay Enhanced Cellular Networks (2007)

Relay enhanced cellular network has been proposed as a promising solution for the next generation wireless system. Based on an appropriate frame structure for such OFDMA based relay network, round-robin algorithm is extended as a performance benchmark. Two special algorithms (greedy polling and partial proportional fair) are proposed for adaptive resource scheduling. Throughput results of simulations show that the proposed adaptive algorithms can achieve significant improvement on system performance and the relay enhanced cellular network outperforms the traditional network significantly for supplying high data rate for users at the cell's edge. The results of jitter's deviation indicate greedy polling algorithm is applicable to realtime service and partial proportional fair algorithm is suitable for non-realtime service.
The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition (2001)

Snail family genes encode DNA binding zinc finger proteins that act as transcriptional repressors. Mouse embryos deficient for the Snail (Sna) gene exhibit defects in the formation of the mesoderm germ layer. In Sna(-/-) mutant embryos, a mesoderm layer forms and mesodermal marker genes are induced but the mutant mesoderm is morphologically abnormal. Lacunae form within the mesoderm layer of the mutant embryos, and cells lining these lacunae retain epithelial characteristics. These cells resemble a columnar epithelium and have apical-basal polarity, with microvilli along the apical surface and intercellular electron-dense adhesive junctions that resemble adherens junctions. E-cadherin expression is retained in the mesoderm of the Sna(-/-) embryos. These defects are strikingly similar to the gastrulation defects observed in snail-deficient Drosophila embryos, suggesting that the mechanism of repression of E-cadherin transcription by Snail family proteins may have been present in the metazoan ancestor of the arthropod and mammalian lineages.
STUDIES IN THE BROMINATION OF STEROID KETONES (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTUDIES IN THE BROMINATION OF STEROID KETONESLEWIS HASTINGS SARETT, PURNENDU NATH CHAKRAVORTY, and EVERETT S. WALLISCite this: J. Org. Chem. 1943, 08, 5, 405–416Publication Date (Print):September 1, 1943Publication History Published online1 May 2002Published inissue 1 September 1943https://pubs.acs.org/doi/10.1021/jo01193a003https://doi.org/10.1021/jo01193a003research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Autophagy inhibition enhances sensitivity of endometrial carcinoma cells to paclitaxel (2015)

Autophagy has been shown to be involved in cancer cell resistance to chemotherapy. Paclitaxel, a widely used chemotherapeutic drug, was demonstrated to induce autophagy in various cancer cells. Therefore, we sought to evaluate the role of autophagy on the paclitaxel-induced cell death in endometrial carcinoma. In this study, we found that paclitaxel induced autophagy in paclitaxel-insensitive HEC-1A and JEC cells, exhibiting an increased microtubule associated protein 1 light chain 3 (LC3)-II/LC3-I ratio, a decrease in p62/SQSTM1 abundance, the upregulation of Beclin 1 expression and punctate dots of yellow fluorescent protein (YFP)-LC3 in the cytosol. Paclitaxel-mediated cell death was further potentiated by pretreatment with autophagy inhibitor chloroquine (CQ) or shRNA against the autophagic gene beclin 1. Moreover, paclitaxel stimulated reactive oxygen species (ROS) generation, and inhibition of the ROS by antioxidant N-acetyl-cysteine (NAC) blocked paclitaxel-induced autophagy, indicating that paclitaxel-induced autophagy in endometrial carcinoma cells is mediated by ROS. These ﬁndings suggest that paclitaxel-elicited autophagic response plays a protective role that impedes the eventual death of endometrial carcinoma cell, and that autophagy-inhibitor therapy could be an effective and potent strategy to improve paclitaxel treatment outcomes in the treatment of endometrial carcinoma.
Automatic microscopic method for determination of melting point (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutomatic microscopic method for determination of melting pointA. K. Kolb, Chi Long. Lee, and R. M. TrailCite this: Anal. Chem. 1967, 39, 10, 1206–1208Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/ac60254a004https://doi.org/10.1021/ac60254a004research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Ambassador of Peace. Vol. I. (1929)

An Ambassador of Peace Get access An Ambassador of Peace. Pages from the Diary of Viscount D'Abernon. Vol. I. 1929. (London: Hodder and Stoughton. 8vo. x + 332 pp. 21s.) H. W. H. H. W. H. Search for other works by this author on: Oxford Academic Google Scholar Journal of the Royal Institute of International Affairs, Volume 8, Issue 2, March 1929, Pages 173–174, https://doi.org/10.2307/3015134 Published: 01 March 1929
Power analysis for semi-custom design (2002)

We present a power analysis system for semi-custom hardware design that operates on a cell level making it a faster alternative to the currently available transistor level systems. Our system allows for the calculation of static and dynamic power consumption of a circuit. Measuring the power consumption is critical for low power design as it enables the designer to meet power specifications, drive power optimization tools, distribute power effectively through a design and choose appropriate packages. Implementation results show that the power analysis system is 4 orders of magnitude faster than circuit-level simulation, with accuracy within 10%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An online signature method using DNA based bio-hash for positive identification and non-repudiation (2017)

This work focuses on using biological data as a unique feature to generate e-Signature. DNA, the blue print of life is of unique nature. The signature created using biological data will be difficult to repudiate in the scenario of a legal dispute. Applications of human DNA are not limited to molecular biology, with the advents of fast growing technologies it is possible to inject DNA into e-Signature for positive identification. The proposed methodology uses Signature DNA as a unique biological feature for the registrant. This work has various phases, the first phase includes creating the Signature DNA using hybridized unique DNA segments of the individual (Registrant) which is the unique identification of the user and difficult to duplicate and repudiate. It generates a Bio-Hash of the Signature DNA. The DNA-Hash generated serves for positive identification of the user which computed with the hash of the e-Document and a random value serve as a Bio-Sign (e-Signature) for the e-Document in the second phase. Bio-Sign converted into QR code with a link to the e-Sign service providers website will ensure usability for verification. In the verification phase the verifier scans the QR code which connects to the e-Service provider's web link. The service provider computes and verifies the document and ensures the e-Signature is valid or not to the verifier. If the signer repudiates the signature, positive identification using DNA helps to achieve Non-Repudiation, the last phase. In the scenario of a legal dispute, the registrant cannot repudiate as the authorities can provide positive identification using the DNA Signature for greater assurance. The proposed technique ensures authentication, integrity and Non-Repudiation with Zero knowledge scenario to the verifier.
Notch3 and pTα/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells (2009)

Dysregulated generation and/or function of naturally occurring 'CD4(+)CD25(+) regulatory T cells' (T(reg)s) play key role in the development of autoimmune diseases, including type 1 diabetes. Recent findings suggest that Notch3 signaling activation promotes thymic generation and peripheral expansion and in vivo function of naturally occurring T(reg)s, thus preventing autoimmune diabetes progression in mouse models. However, the mechanisms underlying these effects have remained elusive, thus far. Here, we show that the expression of pTalpha gene is up-regulated in naturally occurring T(reg)s, at both mRNA and protein levels. Moreover, by using double mutant mice, with T cell-targeted constitutive activation of Notch3 in a pTalpha(-/-) background, we demonstrate that pTalpha deletion significantly counteracts the Notch3-dependent expansion, the increased FoxP3 expression and the enhanced in vitro activity of naturally occurring T(reg)s. Notably, the absence of pTalpha also impairs the Notch3-dependent protection against experimentally induced autoimmune diabetes. Finally, by adoptive cell transfer experiments, we demonstrated that this failure is directly related to the impaired in vivo function of naturally occurring T(reg)s bearing pTalpha deletion. Collectively, our data suggest that pTalpha expression is required for the in vivo function of naturally occurring T(reg)s and that the activation of Notch3 signaling may positively regulate the function of this population, through the pTalpha/pre-T cell receptor pathway.
Weak Polyelectrolyte Brush Arrays Fabricated by Combining Electron-Beam Lithography with Surface-Initiated Photopolymerization (2006)

We present a simple “top-down/bottom-up” strategy to fabricate nano- and micropatterned polymer brush arrays composed of pH- and salt-sensitive, weak polyelectrolyte copolymers [poly(N-isopropylacrylamide-co-methacrylic acid, 3:1, poly(NIPAAM-co-MAA)]. In our approach, a silicon surface is first patterned with gold, using “lift-off” electron-beam lithography (“top-down”), and the resulting pattern is then amplified by surface-initiated photopolymerization by conventional, UV-light-induced free radical polymerization (“bottom-up”) from an immobilized 2,2‘-azobisisobutyronitrile (AIBN) type initiator. The use of pH- and ionic-strength-sensitive comonomers in the copolymer brush enables large, externally triggered conformational changes of the micro- and nanopatterned polymer brushes. We observed that the height of nanopatterned ionized polymer brushes increases with increasing feature size of the pattern. The design and fabrication of surfaces with conformationally switchable, patterned polymeric structures is important for sensing and actuation applications on the micro- and nanoscales.
Studying brain functions with mesoscopic measurements: Advances in electrocorticography for non-human primates (2015)

Our brain is organized in a modular structure. Information in different modalities is processed within distinct cortical areas. However, individual cortical areas cannot enable complex cognitive functions without interacting with other cortical areas. Electrocorticography (ECoG) has recently become an important tool for studying global network activity across cortical areas in animal models. With stable recordings of electrical field potentials from multiple cortical areas, ECoG provides an opportunity to systematically study large-scale cortical activity at a mesoscopic spatiotemporal resolution under various experimental conditions. Recent developments in thin, flexible ECoG electrodes permit recording field potentials from not only gyral but intrasulcal cortical surfaces. Our review here focuses on the recent advances of ECoG applications to non-human primates.
Mixed-valence, conjugated quinone and imide anion radicals. An ESR investigation (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMixed-valence, conjugated quinone and imide anion radicals. An ESR investigationStanton F. Rak and Larry L. MillerCite this: J. Am. Chem. Soc. 1992, 114, 4, 1388–1394Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/ja00030a038https://doi.org/10.1021/ja00030a038research-articleACS PublicationsRequest reuse permissionsArticle Views495Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Viscous fingering of miscible slices (2005)

Viscous fingering of a miscible high viscosity slice of fluid displaced by a lower viscosity fluid is studied in porous media by direct numerical simulations of Darcy’s law coupled to the evolution equation for the concentration of a solute controlling the viscosity of miscible solutions. In contrast with fingering between two semi-infinite regions, fingering of finite slices is a transient phenomenon due to the decrease in time of the viscosity ratio across the interface induced by fingering and dispersion processes. We show that fingering contributes transiently to the broadening of the peak in time by increasing its variance. A quantitative analysis of the asymptotic contribution of fingering to this variance is conducted as a function of the four relevant parameters of the problem, i.e., the log-mobility ratio R, the length of the slice l, the Péclet number Pe, and the ratio between transverse and axial dispersion coefficients ε. Relevance of the results is discussed in relation with transport of viscous samples in chromatographic columns and propagation of contaminants in porous media.
EuroWordNet: a multilingual database for information retrieval (1997)

The aim of the EuroWordNet-project is the development of a database with wordnets for English, Spanish, Dutch and Italian, similar to the Princeton WordNet1.5, which contains basic semantic relations between words in English. The Dutch, Italian and Spanish wordnets will be linked to the WordNet1.5 using equivalence relations. The resulting multilingual database can directly be used in (multi-lingual) information retrieval. In this paper the basic characteristics of this database are described as far as relevant to this purpose. Paper presented at the DELOS workshop on Cross-language Information Retrieval, March 5-7, 1997, Zurich. 1. Introduction EuroWordNet 1 aims to build a multilingual database consisting of wordnets in several European languages (English, Dutch, Italian, and Spanish). Each language-specific wordnet is structured along the same lines as WordNet (Miller et al, 1990), i.e. synonyms are grouped in synsets, which in their turn are related by means of basic semantic ...
Approximate Solutions for an<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>N</mml:mi></mml:math>-Molecule-Radiation-Field Hamiltonian (1969)

Three approximation schemes are discussed and compared with the exact solutions for a Hamiltonian describing the interaction of a single-mode quantized radiation field and $N$ two-level "molecules," each resonant with the mode frequency. In particular, the approximation of treating the molecules as uncorrelated is found to be accurate when the system energy is several times larger than the cooperation number of the molecular system.
Gene Therapy of Inherited Retinopathies: A Long and Successful Road from Viral Vectors to Patients (2012)

Inherited retinopathies (IRs) are common and untreatable blinding conditions inherited mostly as monogenic due to mutations in genes expressed in retinal photoreceptors (PRs) and in retinal pigment epithelium (RPE). Over the last two decades, the retina has emerged as one of the most favorable target tissues for gene therapy given its small size and its enclosed and immune-privileged environment. Different types of viral vectors have been developed, especially those based on the adeno-associated virus (AAV), which efficiently deliver therapeutic genes to PRs or RPE upon subretinal injections. Dozens of successful proofs of concept of the efficacy of gene therapy for recessive and dominant IRs have been generated in small and large models that have paved the way to the first clinical trials using AAV in patients with Leber congenital amaurosis, a severe form of childhood blindness. The results from these initial trials suggest that retinal gene therapy with AAV is safe in humans, that vision can be improved in patients that have suffered from severe impairment of visual function, in some cases for decades, and that readministration of AAV to the subretinal space is feasible, effective, and safe. However, none of the trials could match the levels of efficacy of gene therapy observed in a dog model of the disease, suggesting that there is room for improvement. In conclusion, these results bode well for further testing of AAV-mediated retinal gene therapy in patients with other monogenic and complex forms of blindness.
Nickel(II)‐Komplexe von Oxalamidinen und Oxalamidinaten mit zusätzlichen R<sub>2</sub>P‐Donorgruppen (2004)

Abstract Oxalamidine R 1 N=C(HNR 2 )‐C(=NR 2 )‐NHR 1 , die in zwei der vier N‐Substituenten zusätzliche Donoratome besitzen ( H 2 A : R 1 = Mesityl, R 2 = ‐(CH 2 ) 3 ‐PPh 2 ; H 2 B : R 1 = Tolyl, R 2 = ‐(CH 2 ) 3 ‐PMe 2 ), bilden mit Nickel(II)‐Ionen binucleare Komplexe, in denen ganz unterschiedliche Koordinationsformen realisiert werden. Im Komplex [ (A) Ni 2 Br 2 ] (1) sind die beiden Nickelatome auf jeder Seite der Brücke in planar‐quadratischer Umgebung, koordiniert an den beiden N‐Donoratomen des Oxalamidinatgerüsts, sowie an ein Bromid und eine Ph 2 P‐Gruppe. Eine analoge Koordination besitzt die Organometallverbindung [ (A) Ni 2 Me 2 ] (2) . Im Gegensatz dazu ist die koordinative Umgebung der beiden Nickelatome in der Verbindung {[( B )][Ni(acac)] 2 } (5) unterschiedlich. Auf einer Seite des Oxalamidinatbrückenliganden koordiniert ein (acac)Ni‐Fragment an den beiden N‐Donoratomen unter Ausbildung einer planar‐quadratischen Konfiguration. Auf der gegenüberliegenden Seite ist das (acac)Ni‐Fragment sowohl an die beiden N‐Atome des Brückenliganden als auch an die beiden PMe 2 ‐Gruppen der Seitenketten koordiniert, so dass sich eine oktaedrische Koordination für dieses Nickelatom ergibt.
Reduction of interconnect delay by exploiting cross-talk (2001)

Usually it is thought that cross-talk is deleterious for signal integrity. However, by propagating the same signal over aggressor and victim wires, the victim wire delay is minimised because its lateral capacitance to the aggressors is virtually reduced at the spatial position of the travelling waves. We exploit this cross-talk property to build a 3-wire scheme for interconnect delay reduction, which we also refer to as the booster approach. This approach was experimentally verified on a test-chip, fabricated in a 0.18µm CMOS technology. We observed a 5x-delay reduction over the nominal wire delay. Based on simulations, we further provide a comparison of this novel approach to other well-known approaches like repeater insertion and the fat-wire approach.
Cyclic AMP stimulates a JunD/Fra-2 AP-1 complex and inhibits the proliferation of interleukin-6-dependent cell lines. (1995)

Interleukin-6 (IL-6) is a proinflammatory cytokine which also acts as a growth factor for some murine hybridomas (7TD1) or human myelomas (U266). We demonstrate that elevation of cAMP cellular content inhibits IL-6-stimulated cell growth, by blocking cells mainly in G1 phase. This inhibition is associated with increased expression of the Fos family protein Fra-2. Treatment of cells with 8Br-cAMP results in increased DNA-binding activity of two distinct AP-1 complexes; JunD/Fra-2 and JunB/Fra-2, and also in elevated AP-1 transactivation. When 8Br-cAMP is withdrawn from the medium, cells enter S phase and Fra-2 protein levels and AP-1 DNA-binding activity decrease to their basal value indicating that a temporally correlation exists between the 8Br-cAMP-mediated induction of JunD/Fra-2 AP-1 complex and the 7TD1 and U266 cell growth inhibition.
Characterization of Positive-type Photosensitive Polyimide Films Formed by Electrodeposition Coating (2004)

Soluble polyimides having pendant carboxyl groups were prepared by one-pot polycondensation of 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) with 3,5-diaminobenzoic acid (DABz) and bis[4-(3-aminophenoxy)phenyl]-sulfone (m-BAPS) in the presence of γ-valerolactone/pyridine catalyst system using N-methyl-2-pyrrolidone (NMP)/toluene mixture as a solvent, and used for the electrodeposition coating. Positive-type photosensitive polyimide compositions for electrodeposition coating consisted of the pendant carboxyl-containing polyimide, NMP and cyclohexanone as solvents, N-methylmorpholine as a neutralizing agent, deionized water and diazonaphthoquinone(DNQ) compound(PC-5®) as a photosensitive material. The electrodeposition coating under a fixed voltage provided photosensitive polyimide films with high levels of appearance and smoothness on a copper foil. These photosensitive polyimide films formed by electrodeposition coating gave positive-tone behavior by UV irradiation and following development in an aqueous tetramethylammonium hydroxide(TMAH) or ethanolamine-containing solution. The scanning electron microscopic photographs of the resulting images showed fine and sharp line/space patterns.