gebhart/patrepeval huggingface dataset:
Nitric oxide modulates spontaneous swallowing behavior in near-term ovine fetus (1999)

Human and ovine fetuses demonstrate an enhanced rate of swallowing, an activity critical for amniotic fluid regulation. Fetal swallowing may be modulated by both systemic and central factors. Nitric oxide (NO) is a central neuromodulator that has been localized to brain regions regulating thirst and swallowing. We sought to determine if NO contributes to the regulation of spontaneous ovine fetal swallowing. Six time-dated pregnant ewes with singleton fetuses (129 +/- 1 day) were chronically prepared with fetal vascular and lateral ventricle catheters and electrocorticogram (ECoG) and esophageal electromyogram electrodes. After a 2-h control period, fetuses were given lateral ventricle injection of NO synthase inhibitor nitro-L-arginine methyl ester (L-NAME) and monitored for 2 h. NO precursor L-arginine was then injected into the lateral ventricle, and fetuses were monitored for a final 2 h. All fetuses received an additional control study of fetal swallowing before and after lateral ventricle injection of artificial cerebrospinal fluid (aCSF). Data were analyzed with repeated-measures ANOVA and paired t-test (P < 0.05). Suppression of a central NO with central L-NAME significantly reduced mean (+/-SE) spontaneous fetal swallowing (1.2 +/- 0.1-0.6 +/- 0.1 swallows/min low-voltage ECoG; P < 0.01). Restoration of central NO by L-arginine significantly increased fetal swallowing to pre-L-NAME levels (1.2 +/- 0.1 swallows/min low voltage). There were no changes in fetal swallowing during the control study of aCSF. Fetal ECoG activity and blood pressure did not change during the study or control aCSF injection. We conclude that NO is an important neuromodulator of fetal swallowing activity. Central NO synthase activity may contribute to the heightened level of spontaneous fetal swallowing and thus amniotic fluid regulation.
Winterized Methyl Esters from Soybean Oil:An Alternative Diesel Fuel With Improved Low-Temperature Flow Properties (1997)

<div class="htmlview paragraph">Methyl esters from vegetable oils (biodiesel) are very attractive as alternative fuels for combustion in direct injection compression-ignition (diesel) engines. Biodiesel fuels have low-temperature flow properties that limit utilization during cooler weather in moderate temperature climates. Although winterization reduces the cloud point (CP) of methyl soyate from 0 to -2O°C, liquid product yields were relatively low (0.30-0.33 g/g). Winterization of methyl soyate-cold flow improver mixtures decreased CP by -11°C and increased yields to 0.80-0.87 g/g. Winterization of methyl soyate from hexane and isopropanol solvents gave similar results. Differential scanning calorimetry (DSC) analyses showed that nucleation mechanisms of methyl esters were significantly affected by winterization.</div>
Knowledge and Attitude of Persons Living with HIV+/AIDS (2010)

Problem statement: As number of Persons Living with HIV/AIDS (PLWAs) increases, caring for them is a new rising problem. The World Health Organization encourages caring these people at home. Patients themselves also prefer to stay at home than staying in hospital. Adequate knowledge and positive attitude are important factors in providing better care for a patient. Approach: This study was conducted to assess level of knowledge and describe attitudes existing between family members of PLWAs. A cross-sectional study was conducted on PLWAs to assess the basic level of knowledge and attitude regarding AIDS. One hundred family members of PLWAs were selected using simple random sampling. A three-part questionnaire was delivered to measure HIV/AIDS-related attitude and knowledge. Results: Mean score of participants were 10.692.05 of a maximum of 14 points in knowledge. Knowledge on some aspect of the disease was quite high in the study group; Mean score was 25.426.05 from a maximum of 40 points in attitude. Female gender, higher income and education level were associated with a greater level of knowledge. Parents in comparison with other relatives and persons older than 60 usually had lower level of knowledge. Patients with higher income or education level also had more positive attitude toward patient. Conclusion: The findings of the study suggest that the family members of patients living with AIDS have a satisfactory level of essential knowledge on HIV/AIDS. Most of them have good attitudes toward person with HIV/AIDS. However, there are some misconceptions about the routes of transmission that can be problems on the way of providing homebased care.
Hypersensitive response to Potato virus Y in potato cultivar Sárpo Mira is conferred by the Ny-Smira gene located on the long arm of chromosome IX (2014)

<i>Potato virus Y</i> (PVY, <i>Potyvirus</i>) is the fifth most important plant virus worldwide in terms of economic and scientific impact. It infects members of the family Solanaceae and causes losses in potato, tomato, tobacco, pepper and petunia production. In potato and its wild relatives, two types of resistance genes against PVY have been identified. While <i>Ry</i> genes confer symptomless extreme resistance, <i>Ny</i> genes cause a hypersensitive response visible as local necrosis that may also be able to prevent the virus from spreading under certain environmental conditions. The potato cultivar Sárpo Mira originates from Hungary and is highly resistant to PVY, although the source of this resistance remains unknown. We show that cv. Sárpo Mira reacts with a hypersensitive response leading to necrosis after PVY<sup>NTN</sup> infection in detached leaf, whole plant and grafting assays. The hypersensitivity to PVY<sup>NTN</sup> segregated amongst 140 individuals of tetraploid progeny of cvs. Sárpo Mira × Maris Piper in a 1:1 ratio, indicating that it was conferred by a single, dominant gene in simplex. Moreover, we identified five DNA markers linked to this trait and located the underlying locus (<i>Ny</i>-<i>Smira</i>) to the long arm of potato chromosome IX. This position corresponds to the location of the <i>Ry</i><sub><i>chc</i></sub> and <i>Ny</i>-<i>1</i> genes for PVY resistance. A simple PCR marker, located 1 cM from the <i>Ny</i>-<i>Smira</i> gene, can be recommended for selection of PVY-resistant progeny of cv. Sárpo Mira.
Parameter extraction technique for the small-signal equivalent circuit model of microwave silicon MOSFETs (1997)

The MOSFET equivalent circuit model parameters are determined by performing the refined extraction method using Z-parameter formulations for parasitics and Y-parameter ones for geometric layout, excellent correspondence is observed between measured and fitted data of Z-parameter equations and the extracted intrinsic parameters exhibit mostly frequency-independent behavior. The scaling rule to gate width is observed to be applied for the extracted intrinsic parameters within reasonable errors. These extraction results essentially demonstrate the validity of this method in the wide range of gate bias and layout.
An Experimental Study of Nonuniform Current Distribution at Rotating Disk Electrodes (1970)

The theoretical predictions of Newman (1, 2) concerning the existence of a nonuniform current distribution at rotating disk electrodes have been verified in media containing insufficient supporting electrolyte. Measurements of the thickness of copper films deposited on a platinum disk yield results qualitatively of the form predicted by Newman. The primary current distribution is approached at currents corresponding to a small fraction of the limiting convective diffusion current in the absence of appreciable supporting electrolyte, while a uniform current distribution is found in the limiting current region. Nonuniform current distribution at a disk electrode has been found to have significant effects on the collection efficiency of a ring‐disk electrode. These effects depend markedly on the geometry of the electrode. Similar behavior has been noted in the currents observed at "shielded" rings of ring‐disk electrodes. Under conventional polarographic conditions in solutions containing fifty‐ to a hundred‐fold excess of supporting electrolyte, no significant deviations from a uniform disk current distribution could be detected.
Attentive Explanations: Justifying Decisions and Pointing to the Evidence (2016)

Deep models are the defacto standard in visual decision models due to their impressive performance on a wide array of visual tasks. However, they are frequently seen as opaque and are unable to explain their decisions. In contrast, humans can justify their decisions with natural language and point to the evidence in the visual world which led to their decisions. We postulate that deep models can do this as well and propose our Pointing and Justification (PJ-X) model which can justify its decision with a sentence and point to the evidence by introspecting its decision and explanation process using an attention mechanism. Unfortunately there is no dataset available with reference explanations for visual decision making. We thus collect two datasets in two domains where it is interesting and challenging to explain decisions. First, we extend the visual question answering task to not only provide an answer but also a natural language explanation for the answer. Second, we focus on explaining human activities which is traditionally more challenging than object classification. We extensively evaluate our PJ-X model, both on the justification and pointing tasks, by comparing it to prior models and ablations using both automatic and human evaluations.
Expression of the human major vault protein LRP in acute myeloid leukemia. (1997)

Overexpression of a 110-kD protein (lung resistance-related protein [LRP]) may predict a poor response to chemotherapy in patients with acute myeloid leukemia (AML) and ovarian carcinoma. The LRP gene has recently been mapped to chromosome 16, close to the multidrug resistance-associated protein (MRP) gene. Seventy-seven samples from 67 patients with AML were examined for expression of LRP, MRP, and multidrug resistance (MDR1) mRNA using a semiquantitative reverse transcription polymerase chain reaction (RT-PCR) assay. Results were compared with 29 normal samples (11 normal peripheral blood and 18 normal bone marrow). Thirty-three patients with untreated AML were evaluable for response to chemotherapy. Levels of LRP, but not of MRP or MDR1 mRNA, were significantly higher in eight patients who failed to achieve complete remission (CR) compared with 25 patients who achieved CR (p = 0.033). A positive correlation was demonstrated between LRP and MRP (R = 0.368, p = 0.001) and between MRP and MDR1 mRNA levels (R = 0.301, p = 0.01) in the 77 clinical samples analyzed. In AML samples, a significant difference in MDR1 mRNA levels was found between presentation (47 samples) and relapse (30 samples) (p = 0.031). No significant difference was seen in LRP mRNA levels between these two groups or in eight patients studied sequentially at both presentation and relapse. Thirteen samples (10 at presentation, 3 at relapse) were analyzed for LRP protein expression by flow cytometry. Eight (5 at presentation, 3 at relapse) displayed greater than 10% positive cells (range 15-86%). These data suggest that LRP gene overexpression may constitute a novel mechanism of multidrug resistance.
Effect of <i>meta</i>-Carborane on Segmental Dynamics in a Bimodal Poly(dimethylsiloxane) Network (2008)

Bimodal networks of polydimethylsiloxane (PDMS) filled with varying amounts of icosahedral meta-carborane (m-CB) have been developed and characterized by broadband dielectric spectroscopy (BDS) and static 1H multiple quantum nuclear magnetic resonance (MQ NMR). Both BDS and MQ NMR showed evidence for a decrease in the polymer chain dynamics. BDS spectra quantified a normal-mode relaxation near 40 Hz at 40 °C. The frequency maximum observed for filled samples decreased with increasing m-CB content until contents greater than 5 wt %. The width of the relaxation spectrum increased with the addition of small quantities of filler and decreased with filler contents greater that 5 wt %. Agglomeration effects were observed at loadings greater than 5 wt % as manifest by the onset of low frequency Maxwell−Wagner−Sillars (MWS) processes. The MQ NMR data allowed the characterization of distributions of the residual dipolar couplings, <Ωd> and, thus, in the dynamic order parameter, Sb, consistent with the bimodal network architecture expected from the synthesis protocol used. Upon addition of less than 10 wt % m-CB filler, the mean <Ωd> for the longer chains increased by 46% and the width of the distribution increased by 33%. The mean <Ωd> for the shorter chains increased by much less, indicative of preferential dispersion of the filler particles in the long chain domains of the network structure. We conclude that the mechanism of reinforcement is likely free volume space filling at low loadings transitioning to complex molecular filler and polymer chain interaction phenomena at higher loadings.
Editorial: T Cell Differentiation and Function in Tissue Inflammation (2020)

EDITORIAL article Front. Immunol., 21 February 2020Sec. T Cell Biology Volume 11 - 2020 | https://doi.org/10.3389/fimmu.2020.00289
Alternative Polyadenylation of Adeno-Associated Virus Type 5 RNA within an Internal Intron Is Governed by both a Downstream Element within the Intron 3′ Splice Acceptor and an Element Upstream of the P41 Initiation Site (2003)

Adeno-associated virus type 5 (AAV5) has a linear, single-stranded DNA genome of ca. 5 kb and an overlapping transcription profile featuring multiple promoters and a single intron in the center of the genome. Unlike the situation for the prototype AAV2, AAV5 RNAs transcribed from upstream promoters at map units 7 (P7) and 19 (P19), which encode the viral Rep proteins, are predominantly polyadenylated at a site within the intron [(pA)p]. RNAs generated from the AAV5 capsid gene promoter P41, which is only 78 nucleotides (nt) upstream of the intron donor, and 281 nt upstream of (pA)p, primarily readthrough (pA)p, are polyadenylated at a more distal site at the 3' end of the genome [(pA)d] and ultimately spliced. The intron contains the core sequences sufficient for polyadenylation at (pA)p, which is governed by a G/U-rich downstream element that overlaps with the intron 3' A2 splice acceptor. In addition, polyadenylation of P7- and P19-generated RNAs at (pA)p is influenced by an upstream element that lies 5' to the start of the P41 transcript. Our results also suggest that splicing and polyadenylation of P41-generated RNA can compete for the same pool of precursor pre-mRNA molecules. The cis-acting signals within the A2 3' splice site that govern polyadenylation and splicing of AAV5 RNAs must be optimized to program both (i) the levels of polyadenylation of P7- and P19-generated RNA at (pA)p required to generate the proper levels of the essential Rep proteins and (ii) the splicing of P41-generated RNAs to generate the proper ratio of capsid proteins during AAV5 infection.
Tantalum as a buffer layer in diamond‐like carbon coated artificial hip joints (2003)

The acid resistance of tantalum coated and uncoated human hip joint prostheses was studied with commercial CrCoMo acetabular cups. The samples were exposed to 10% HCl solution and the quantities of dissolved Cr, Co, and Mo were measured with proton-induced X-ray emission (PIXE). The absolute quantities were obtained with the use of Cr and Se solution standards. Tantalum coatings (thicknesses 4-6 microm) were prepared in vacuum with magnetron sputtering. Tantalum coating decreased the corrosion rate by a factor of 10(6). As a spinoff from recent wear tests on artificial hip joints it was shown that tantalum has excellent mechanical properties as an intermediate layer of diamond-like carbon (DLC) coatings. When tantalum was tested together with DLC on three metal-on-metal hip joint pairs in a hip simulator, no observable defects occurred during 15 million walking cycles with a periodic 50-300-kg load (Paul curve).
A hybrid Lagrangian-Eulerian formulation for bubble generation and dynamics (2013)

We present a hybrid Lagrangian-Eulerian framework for simulating both small and large scale bubble dynamics, where the bubbles can grow or shrink in volume as dictated by pressure forces in the surrounding fluid. Small under-resolved bubbles are evolved using Lagrangian particles that are monolithically two-way coupled to the surrounding flow in a manner that closely approximates the analytic bubble oscillation frequency while converging to the analytic volume as predicted by the well-known Rayleigh-Plesset equation. We present a novel scheme for interconverting between these under-resolved Lagrangian bubbles and larger well-resolved bubbles that are modeled with a traditional Eulerian level set approach. We also present a novel seeding mechanism to realistically generate bubbles when simulating fluid structure interaction with complex objects such as ship propellers. Moreover, our framework for bubble generation is general enough to be incorporated into all grid-based as well as particle-based fluid simulation methods.
Remotely nano-rupturable yolk/shell capsules for magnetically-triggered drug release (2010)

Yolk/shell capsules containing a volume/hydrophobicity transformable core and an ultra-thin silica shell have been prepared. When an external magnetic field induced the temperature, the cores exhibit a significant triggering size shrinkage and the diameter decreases more than 10 times, causing solid shells destruction and physical collapse, leading to drug burst release.
Linear Circuit Analysis (1995)

Lapice transfrom analysis- basics Laplace transfrom analysis - circuit applications Laplace transform analysis - transfer function applications time domain circuit response computations the convolution method resonant and bandpass circuits magnetically coupled circuits and transformers two-ports analysis of interconnected two-ports principles of basic filtering Fourier series with applications to electronic circuits. Appendices: introduction to magnetic circuit analysis SPICE for basic circuits.
Structure of the snake-venom toxin convulxin (2003)

Snake venoms contain a number of proteins that interact with components of the haemostatic system that promote or inhibit events leading to blood-clot formation. The snake-venom protein convulxin (Cvx) binds glycoprotein (GP) VI, the platelet receptor for collagen, and triggers signal transduction. Here, the 2.7 A resolution crystal structure of Cvx is presented. In common with other members of this snake-venom protein family, Cvx is an alphabeta-heterodimer and conforms to the C-type lectin-fold topology. Comparison with other family members allows a set of Cvx residues that form a concave surface to be putatively implicated in GPVI binding. Unlike other family members, with the exception of flavocetin-A (FL-A), Cvx forms an (alphabeta)(4) tetramer. This oligomeric structure is consistent with Cvx clustering GPVI molecules on the surface of platelets and as a result promoting signal transduction activity. The Cvx structure and the location of the putative binding sites suggest a model for this multimeric signalling assembly.
Magnetic Source Imaging in Stereotactic and Functional Neurosurgery (1999)

Magnetic source imaging (MSI) combines the unique spatial and temporal functional accuracy of magnetoencephalography (MEG) with the anatomic and pathologic detail of magnetic resonance (MR). This relatively new method of evaluating brain function provides a preoperative mapping of brain function and brain structure by integrating the functional information of MEG with the structural information of MR. This results in data on actual neuronal interactions in clinical patients. The temporal and spatial accuracy of the MEG data, combined with the anatomic and pathologic specificity of MRI, results in the magnetic source image, which offers accurate knowledge of cortical functional organization, and is important in the surgical treatment of brain neoplasms, vascular malformations, and epilepsy. MSI allows the tracking of neuronal activity on the scale of milliseconds with millimeter accuracy, and continues to lead to new understanding of many functional brain disorders.
Burroughs B1700 memory utilization (1972)

Squeezing more information into memory is a familiar problem to everyone who has written a program which was too large to fit into memory. Program compaction is also important to those who work on machines with virtual memory (such as the B5500); despite the almost unlimited amount of storage, one wants to keep program working-sets (collections of segments needed in core at the same time) as small as possible to reduce both the number and duration of segment swaps. In general, one seeks to raise the information content (or reduce the redundancy) of the blocks of information which one is using. In this discussion, "information content" will suffice as an intuitive notion.
The recalcification plasma clotting time. A valuable general clotting test in man and rats (1969)

An improved method for determining the recalcification plasma clotting time (PCT) in siliconized and plastic material is described. Provided the plasma is stored at 29–30 °C, this general clotting test appears to give highly accurate and reproducible results. The PCT values were found to be related to the in vivo platelet count in rat, and to the total serum cholesterol and plasma fibrinogen in man. Serial determinations in two women indicated that the PCT was subject to periodic fluctuations connected with the menstrual cycle. Finally, it was observed that the clotting time of both platelet-rich and -poor plasma was inversely related to the severity of large hepatic vein thrombosis initiated by the injection of a S. typhosa endotoxin in hyperlipemic rats.
The Human Papillomavirus 16 E6 Protein Binds to Tumor Necrosis Factor (TNF) R1 and Protects Cells from TNF-induced Apoptosis (2002)

High risk strains of human papillomavirus (HPV), such as HPV 16, cause human cervical carcinoma. The E6 protein of HPV 16 mediates the rapid degradation of p53, although this is not the only function of E6 and cannot completely explain its transforming potential. Previous work in our laboratory has demonstrated that transfection of HPV 16 E6 into the tumor necrosis factor (TNF)-sensitive LM cell line protects expressing cells from TNF-induced apoptosis in a p53-independent manner, and the purpose of this study was to determine the molecular mechanism underlying this protection. Caspase 3 and caspase 8 activation were significantly reduced in E6-expressing cells, indicating that E6 acts early in the TNF apoptotic pathway. In fact, E6 binds directly to TNF R1, as shown both by co-immunoprecipitation and mammalian two-hybrid approaches. E6 requires the same C-terminal portion of TNF R1 for binding as does TNF R1-associated death domain, and TNF R1/TNF R1-associated death domain interactions are decreased in the presence of E6. HA-E6 also blocked cell death triggered by transfection of the death domain of TNF R1. Together, these results provide strong support for a model in which HPV E6 binding to TNF R1 interferes with formation of the death-inducing signaling complex and thus with transduction of proapoptotic signals. They also demonstrate that HPV, like several other viruses, has developed a method for evading the TNF-mediated host immune response.