gebhart/patrepeval huggingface dataset:
Non-genetic heterogeneity of cells in development: more than just noise (2009)

Cell-to-cell variability of gene expression in clonal populations of mammalian cells is ubiquitous. However, because molecular biologists habitually assume uniformity of the cell populations that serve as starting material for experimental analysis, attention to such non-genetic heterogeneity has been scant. As awareness of, and interest in, understanding its biological significance increases, this Primer attempts to clarify the confusing terminologies used in an emerging field that often conflates heterogeneity with noise, and provides a qualitative introduction to the fundamental dynamic principles that underlie heterogeneity. It thus aims to present a useful conceptual framework to organize, analyze and communicate observations made at the resolution of individual cells that indicate that heterogeneity of cell populations plays a biological role, such as in multipotency and cell fate decision.
Creutzfeldt-Jakob Disease: Recommendations for Disinfection and Sterilization (2001)

Prion diseases constitute a unique infection control problem because prions exhibit unusual resistance to conventional chemical and physical decontamination methods. Recommendations to prevent cross-transmission of infection from medical devices contaminated by Creutzfeldt-Jakob disease (CJD) have been based primarily on prion inactivation studies. The recommendations in this article consider inactivation data but also use epidemiological studies of prion transmission, infectivity of human tissues, and efficacy of removing microbes by cleaning. On the basis of the scientific data, only critical (e.g., surgical instruments) and semicritical devices contaminated with high-risk tissue (i.e., brain, spinal cord, and eye tissue) from high-risk patients--those with known or suspected infection with CJD--require special treatment.
Role of the small bowel in regulating food intake in rats (1982)

This study tested the hypothesis that exposure of the lower intestine to nutrients decreases subsequent food intake. Eight male Sprague-Dawley rats underwent jejunoileal bypass surgery with 8 cm of proximal jejunum anastomosed to 5 cm of terminal ileum in an end-to-side fashion. Eight control rats had sham bypass surgery with similar intestinal incisions that were reanastomosed in normal continuity. Another group of eight rats underwent ileal transposition (IT). A 10-cm segment of terminal ileum was transected, leaving the mesentery and blood supply intact, and transposed to the jejunum 8 cm from the ligament of Treitz. Thus total intestinal length was intact. Eight control rats had similar intestinal transections reanastomosed in normal continuity. A similar pattern of decreased food intake in the first 1-2 wk occurred in both bypass and IT rats. The values were significantly different from the respective sham surgery control groups. Body weights decreased, but the fall was greater in bypass rats. These data suggest that partially digested food in the lower intestine decreases food intake.
159. Anhydro-compounds from nitrogen-containing derivatives of thioglycollic acid. Part I. Pyridine and quinoline compounds (1951)

G. F. Duffin and J. D. Kendall, J. Chem. Soc., 1951, 734 DOI: 10.1039/JR9510000734
Robust Detection of Region-Duplication Forgery in Digital Image (2006)

Region duplication forgery, in which a part of a digital image is copied and then pasted to another portion of the same image in order to conceal an important object in the scene, is one of the common image forgery techniques. In this paper, we describe an efficient and robust algorithm for detecting and localizing this type of malicious tampering. We present experimental results which show that our method is robust and can successfully detect this type of tampering for images that have been subjected to various forms of post region duplication image processing, including blurring, noise contamination, severe lossy compression, and a mixture of these processing operations
Mixed grammar, purist grammar, and language attitudes in modern Nahuatl (1980)

ABSTRACT In Tlaxcala and Puebla, Mexico, Nahuatl is being replaced by Spanish. Economic and social factors, principally a shift from a peripheral agrarian integration in the Mexican economy to integration as a rural proletariat involved in migratory labor, has been accompanied by a shift in language attitudes which has led to a narrowing of the range of functions of Nahuatl to a function primarily as a “language of solidarity.” This narrowing of function and the accompanying development of ethnic self-consciousness and egalitarianism are expressed through the stigmatization of Spanish loan words, other ethnic boundary-marking usages, the narrowing of honorific usage, and the differentiation of Nahuatl from Spanish grammar in noun-number constructions. (Nahuatl, Spanish, language shift, ethnicity.)
A phased array calibration technique using eigenstructure methods (2002)

An eigenstructure-based method for direction finding in the presence of angularly dependent sensor phase and gain perturbations is presented. One application for this technique is the calibration of a radar array degraded by mutual coupling effects. The method simultaneously computes an estimate of the angle of arrival of a single source and calibrates the array for that specific angle. A calibration curve for a range of angles is derived by using polynomial interpolation to fit a small set of measured calibration points. Since the technique is a variation of the MUSIC processor for angle estimation, it is applicable to both uniform and nonuniform linear array configurations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hematopoietic placental protein 14. An immunosuppressive factor in cells of the megakaryocytic lineage. (1994)

Placental protein 14 (PP14), an immunosuppressive molecule previously known to be expressed in the female and male reproductive tracts only, was shown to be expressed by hematopoietic cells of the megakaryocytic lineage. Northern blot analysis confirmed the induction specificity of PP14 mRNA in phorbol ester-treated K562 cells. Potent immunosuppressive activity in conditioned medium from phorbol ester-treated K562 cells was attributed to hematopoietic PP14 by anti-PP14 antibody blocking. Immunoprecipitation with anti-PP14 antibodies from conditioned medium revealed two distinct PP14 protein isoforms, designated PP14.1 and PP14.2. Polymerase chain reaction cloning and analysis demonstrated the presence of distinct mRNA counterparts to PP14.1 and PP14.2 that had not been resolved by Northern blot analyses. Hematopoietic PP14.1 mRNA corresponds in size to endometrial PP14 mRNA, whereas the smaller hematopoietic PP14.2 mRNA displays an internal in-frame 66-nucleotide deletion that can be explained by alternative splicing and predicts a 22-amino-acid deletion in the encoded gene product. Both PP14 mRNA isoforms were additionally detected by reverse transcriptase polymerase chain reaction analyses in two human megakaryocytic cell lines and in normal human megakaryocytes and platelets. PP14 mRNA was not detected by reverse transcriptase polymerase chain reaction in a panel of nonhematopoietic, nonendometrial tissues examined. The finding of hematopoietic PP14 within the megakaryocytic lineage provides an additional regulatory link between the coagulation and immune systems in normal and pathological settings.
Xenotransplantation of Microencapsulated Canine Islets into Diabetic Rats (1994)

Islets of Langerhans were isolated in high yields from canine pancreata. In the procedure, the pancreata were perfused and digested with collagenase, and the islets were then purified on histopaque density gradients. As many as 60,000 islets were isolated from a single pancreas. Islets were encapsulated in alginate-polylysine-alginate membranes with the aid of an air-jet droplet generator. In vitro studies demonstrated that the isolated and encapsulated islets secreted insulin in response to glucose and IBMX challenge for at least 9 weeks. In in vivo studies 6 diabetic Wistar rats were transplanted with 5,000 to 8,000 encapsulated islets each. The diabetic condition was reversed in all recipients for up to 112 days. In control animals, which received free, unencapsulated islets, the xenografts remained functional for fewer than 21 days. Microcapsules retrieved from normoglycemic transplant recipients 1 and 2 months posttransplantation were shown to contain viable islet tissue, and no cellular overgrowth was observed on capsular surfaces. The results of the study indicate a considerable clinical potential of microencapsulated canine islet xenografts.
Effect of Silicon Content over Fe-Cu-Si/C Based Composite Anode for Lithium Ion Battery (2008)

Two different anode composite materials comprising of Fe, Cu and Si prepared using high energy ball milling (HEBM) were explored for their capacity and cycling behaviors. Prepared powder composites in the ratio Cu:Fe:Si = 1:1:2.5 and 1:1:3.5 were characterized through X-Ray diffraction (XRD) and scanning electron microscope (SEM). Nevertheless, the XRD shows absence of any new alloy/compound formation upon ball milling, the elements present in Cu(1)Fe(1)Si(2.5)/Graphite composite along with insito generated Li2O demonstrate a superior anodic behavior and delivers a reversible capacity of 340 mAh/g with a high coulombic efficiency (98%). The higher silicon content Cu(1)Fe(1)Si(3.5) along with graphite could not sustain capacity with cycling possibly due to ineffective buffer action of the anode constituents.
Operator locality in the quantum simulation of fermionic models (2017)

Simulating fermionic lattice models with qubits requires mapping fermionic degrees of freedom to qubits. The simplest method for this task, the Jordan-Wigner transformation, yields strings of Pauli operators acting on an extensive number of qubits. This overhead can be a hindrance to implementation of qubit-based quantum simulators, especially in the analog context. Here we thus review and analyze alternative fermion-to-qubit mappings, including the two approaches by Bravyi and Kitaev and the auxiliary fermion transformation. The Bravyi-Kitaev transform is reformulated in terms of a classical data structure and generalized to achieve a further locality improvement for local fermionic models on a rectangular lattice. We conclude that the most compact encoding of the fermionic operators can be done using ancilla qubits with the auxiliary fermion scheme. Without introducing ancillas, a variant of the Bravyi-Kitaev transform provides the most compact fermion-to-qubit mapping for Hubbard-like models.
Body Size and Fat Distribution as Predictors of Coronary Heart Disease among Middle-aged and Older US Men (1995)

Obesity, android fat distribution, and other anthropometric measures have been associated with coronary heart disease in long-term prospective studies. However, fluctuations in weight due to age-related hormonal changes and changes in lifestyle practices may bias relative risk estimates over a long follow-up period. The authors prospectively studied the association between body mass index (BMI) (kg/m2), waist-to-hip ratio, and height as independent predictors of incident coronary heart disease in a 3-year prospective study among 29,122 US men aged 40-75 years in 1986. The authors documented 420 incident coronary events during the follow-up period. Body mass index, waist-to-hip ratio, short stature, and weight gain since age 21 were associated with an increased risk of coronary heart disease. Among men younger than 65, after adjusting for other coronary risk factors, the relative risk was 1.72 (95% confidence interval (CI) 1.10-2.69) for men with BMI of 25-28.9, 2.61 (95% CI 1.54-4.42) for BMI of 29.0-32.9, and 3.44 (95% CI 1.67-7.09) for obese men with BMI > or = 33 compared with lean men with BMI < 23.0. Among men > or = 65 years of age, the association between BMI and risk of coronary heart disease was much weaker. However, in this age group, the waist-to-hip ratio was a much stronger predictor of risk (relative risk = 2.76, 95% CI 1.22-6.23 between extreme quintiles). These results suggest that for younger men, obesity, independent of fat distribution, is a strong risk factor for coronary heart disease. For older men, measures of fat distribution may be better than body mass index at predicting risk of coronary disease.
Oxygenated species in the products of fluorination of [60]- and [70]-fullerene by fluorine gas (1995)

Fluorination of pure [60]fullerene and [70]fullerene by fluorine gas shows batch variation, and is accompanied by colour changes as fluorine slowly penetrates the fullerene lattice. Attempted partial fluorination produces a mixture of highly and unfluorinated material due to this slow penetration. [60] Fullerene undergoes fluorination more slowly than [70]fullerene, due to better packing of the crystal lattice in the former, and this explains why [60]fullerene contaminated with [70]fullerene is fluorinated faster than pure [60]fullerene. The NMR spectrum of fluorinated [70]fullerene shows a number of singlets between δ–151.2 and –153.65, indicating the formation of a mixture of derivatives each possessing high symmetry. The IR of fluorinated [70]fullerene shows a broad band at 1112 cm–1. The mass spectra of fluorinated [60]- and [70]-fullerenes reveals species containing up to eleven and sixteen oxygen atoms, respectively (DCl probe, deposition from dichloromethane), or up to eighteen oxygen atoms in each case (deposition from methanol). The maximum site occupancies of species detected (assuming that oxygen is present as the epoxide) are 68 and 70, respectively. Methylene- and (after reaction with methanol) trifluoromethyl-containing species are also evident in the mass spectrum of fluorinated [60]fullerene; corresponding species are not found in fluorinated [70]fullerene. The high level of epoxide formation with the fluorofullerenes indicates that the tendency for fullerenes generally to form epoxides derives from the strong electron withdrawal by the cages.
Appearance of a Host Protein in Cucumber Plants Infected with Viruses, Bacteria and Fungi (1982)

Electrophoretic analyses of extracts of cucumber leaves infected with <it>Colleiotrichum lagenarium, Fusarium oxysporum</it> f. sp. <it>cucumerinum, Pseudomonas lachrymans, Erwinia tracheiphila</it>, tobacco necrosis virus or cucumber mosaic virus revealed the presence of a protein band with an R<inf>F</inf> value of 0.55–0.60 (based on mobility of bromophenol blue) on 10&percnt; polyacrylamide gel. This band was not evident in extracts of healthy or mechanically wounded leaves. The protein was not detected in uninfected leaves of infected plants, but it was detected in similar amounts in infected leaves and in secondarily challenged leaves of infected plants even though symptoms were not apparent on the latter. The protein had a molecular weight of approximately 16 000 d, was adsorbed on DEAE-cellulose, did not react with Schiff's reagent, and did not have ribonuclease activity. When injected into cucumber leaves, it did not inhibit germination of conidia of <it>C. lagenarium</it> or induce resistance against disease caused by the fungus.
Frame relaying as a common access to N-ISDN and B-ISDN data services (1994)

Widespread use of personal computers (PCs) and PC networks is leading to a strongly increased demand for WAN data services in terms of number of accesses and required bandwidth. Narrowband ISDN (N-ISDN) and broadband ISDN (B-ISDN) have the potential to satisfy, respectively, the existing and developing requirements. However, a flexible evolution path needs to be identified for the provision of ISDN access facilities. Frame relaying and frame switching are prime candidates for such a common access facility, although not necessarily intrinsic B-ISDN data services. The article gives an overview of frame relaying and frame switching as possible candidates for harmonized access to N-ISDN and B-ISDN. Pre-ISDN, N-ISDN, and B-ISDN services with their characteristics in terms of cost and performance are first described. It is shown how frame relaying and switching are positioned with respect to the identified service requirements. Then some examples are given of selected scenarios, and the role played by specifically frame relaying to provide access to B-ISDN services, offering at the same time a seamless evolutionary path from N-ISDN to B-ISDN. The position of frame relaying and switching is discussed first in respect to application requirements, and then in architectural terms. Frame relay (and frame switching) services are then identified as services that provide the necessary low threshold and short lead time for rapid market penetration, in order to allow applications to indirectly take advantage of the benefits of ATM services.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Improving the SVDD Approach to Hyperspectral Image Classification (2012)

In recent studies, the support vector data description (SVDD) has been successfully applied to the classification of hyperspectral images. However, there is a major problem with this approach, namely, the precise setting of the Gaussian kernel width (i.e., the sigma), which is, in fact, the common limitation of kernel methods in achieving a reliable performance. Generally, the sigma is tuned for multiclass data sets through the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> -fold cross validation ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> CV), a time-consuming method. To reduce the computation time in real-time applications, typically, the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> CV is used to constrain all the involved SVDD classifiers to share the same sigma. This letter presents a fast and straightforward method to estimate the sigma for each individual SVDD classifier based on statistical properties of the Gaussian kernel. To evaluate the performance of the proposed method, three frequently used hyperspectral data sets are employed. The results are then compared to the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> CV method for sigma selection, and, in addition, two direct sigma estimation methods. Preliminary results using incomplete training data suggest that the proposed method can achieve similar or better performance with faster processing times than the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K</i> CV and also provide a significant superior performance in comparison with the direct methods.
Theory of amplifier-noise evasion in an oscillator employing a nonlinear resonator (1995)

Resonators driven into self-oscillation via active feedback often form the basis of clocks and other sensitive measurement instrumentation. The phase stability of such an oscillator is ultimately limited by the noise associated with the resonator's intrinsic losses. However, it is often the case that amplifier noise is the dominant cause of the oscillator's phase diffusion. Here it is shown that when the resonator possesses a suitable nonlinearity, the phase diffusion due to amplifier noise can be suppressed, allowing one to achieve a long-term phase stability comparable to the ultimate noise limit.
Efficacy of Cyclin Dependent Kinase 4 Inhibitors as Potent Neuroprotective Agents against Insults Relevant to Alzheimer’s Disease (2013)

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure till today. Aberrant activation of cell cycle regulatory proteins is implicated in neurodegenerative diseases including AD. We and others have shown that Cyclin dependent kinase 4 (Cdk4) is activated in AD brain and is required for neuron death. In this study, we tested the efficiency of commercially available Cdk4 specific inhibitors as well as a small library of synthetic molecule inhibitors targeting Cdk4 as neuroprotective agents in cellular models of neuron death. We found that several of these inhibitors significantly protected neuronal cells against death induced by nerve growth factor (NGF) deprivation and oligomeric beta amyloid (Aβ) that are implicated in AD. These neuroprotective agents inhibit specifically Cdk4 kinase activity, loss of mitochondrial integrity, induction of pro-apoptotic protein Bim and caspase3 activation in response to NGF deprivation. The efficacies of commercial and synthesized inhibitors are comparable. The synthesized molecules are either phenanthrene based or naphthalene based and they are synthesized by using Pschorr reaction and Buchwald coupling respectively as one of the key steps. A number of molecules of both kinds block neurodegeneration effectively. Therefore, we propose that Cdk4 inhibition would be a therapeutic choice for ameliorating neurodegeneration in AD and these synthetic Cdk4 inhibitors could lead to development of effective drugs for AD.
A Novel Exposure System for the Efficient and Controlled Deposition of Aerosol Particles onto Cell Cultures (2008)

Epidemiologic studies have shown correlations between morbidity and particles < or = 2.5 microm generated from pollution processes and manufactured nanoparticles. Thereby nanoparticles seem to play a specific role. The interaction of particles with the lung, the main pathway of undesired particle uptake, is poorly understood. In most studies investigating these interactions in vitro, particle deposition differs greatly from the in vivo situation, causing controversial results. We present a nanoparticle deposition chamber to expose lung cells mimicking closely the particle deposition conditions in the lung. In this new deposition chamber, particles are deposited very efficiently, reproducibly, and uniformly onto the cell culture, a key aspect if cell responses are quantified in respect to the deposited particle number. In situ analyses of the lung cells, e.g., the ciliary beat frequency, indicative of the defense capability of the cells, are complemented by off-line biochemical, physiological, and morphological cell analyses.
THE PLATINUM COMPLEX CATALYZED TRANSFORMATION OF PRIMARY AMINE TO SECONDARY AMINE (1984)

Abstract Platinum complex combined with SnCl2·2H2O activates a primary amine and catalyzes the transformation to the secondary amine at 180 °C. Dibutylamine was obtained from butylamine in 74% yield.
Noninvasive Hemodynamic Monitoring of Critical Patients in the Emergency Department (1996)

Noninvasive monitoring can provide hemodynamic and perfusion information previously available only by invasive thermodilution catheters. Such noninvasive monitoring can display continuous on-line real-time data, allowing immediate recognition of circulatory abnormalities and providing a means to titrate therapy to appropriate therapeutic goals.
Three-Dimensional Nickel-Zinc Microbatteries (2006)

A silicon-micromachined rechargeable nickel-zinc alkaline microbattery featuring out-of-plane interdigitated electrodes is reported. The three-dimensional (3-D) battery architecture offers a new approach in developing miniaturized power sources to provide enough power and energy density for autonomous MEMS devices and microelectronic circuits on their small foot print. The battery consists of nickel hydroxide cathode and zinc anode post electrodes which are densely packed in an interdigitated manner. The posts are 50 µ m in diameter and 400 µ m tall, with foot print area of 5x5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Initial prototypes demonstrated a functional battery for the first few cycles of operation.