gebhart/patrepeval huggingface dataset:
Nanoelectropulse Intracellular Perturbation and Electropermeabilization Technology: Phospholipid Translocation, Calcium Bursts, Chromatin Rearrangement, Cardiomyocyte Activation, and Tumor Cell Sensitivity (2005)

Nanosecond, megavolt-per-meter pulsed electric fields scramble the asymmetric arrangement of phospholipids in the plasma membrane, release intracellular calcium, trigger cardiomyocyte activity, and induce apoptosis in mammalian cancer cells, without the permeabilizing effects associated with longer, lower-field pulses. Dose dependencies with respect to pulse width, amplitude, and repetition rate, and total pulse count are observed for all of these phenomena. Sensitivities vary among cell types; cells of lymphoid origin growing in suspension are more susceptible to nanoelectropulse exposure than solid tumor lines. Simple electrical models of the cell are useful for first-order explanations, but more sophisticated treatments will be required for analysis and prediction at both biomolecular and tissue levels.
Dynamically adaptive fetch size prediction for data caches (2004)

Cache line size has a significant impact on cache and overall CPU performance. This size is typically fixed at design time and may not be optimal for a given program or even within a program. Past attempts to achieve an effect of dynamic line size require complex hardware fetch size predictors. This paper proposes an adaptive fetch size predictor based on miss rate sampling. It requires little additional hardware and is straightforward to implement. Adaptive fetch size can be used at either L1 or L2 caches and achieves significant miss rate reductions in both cases. On average, the L2 adaptive fetch size cache results in highest overall performance improvements: 15% average speedup and up to 50% speedup in individual programs.
<sup>1</sup>H and <sup>13</sup>C chemical shifts for tetracycle‐fused acridine analogues of amsacrine (2001)

Abstract The 1 H and 13 C NMR resonances for 18 tetracyclic acridines 9‐substituted on the acridine ring with Cl, NH 2 and AMS [ N ‐(4‐amino‐3‐methoxyphenyl)1methanesulfonamide] groups were completely and unequivocally assigned by the concerted application of gs‐HMQC and gs‐HMBC experiments. For NH 2 and AMS substituents, the potential amino–imino tautomerism is completely shifted towards the imino tautomer. Copyright © 2001 John Wiley & Sons, Ltd.
Luminescent Open‐Framework Antiferromagnet – Hydrothermal Syntheses, Structures, and Luminescent and Magnetic Properties of Two Novel Coordination Polymers: [Zn(pdoa)(bipy)]<i><sub>n</sub></i> and {[Mn(pdoa)(bipy)](bipy)}<i><sub>n</sub></i> [pdoa = 2,2′‐(1,3‐phenylenedioxy)bis(acetate); bipy = 4,4′‐bipyridine] (2006)

Abstract Two coordination polymers of mixed ligands, 2,2′‐(1,3‐phenylenedioxy)bis(acetate) (pdoa) and 4,4′‐bipyridine (bipy),namely [Zn(pdoa)(bipy)] n ( 1 ) and {[Mn(pdoa)(bipy)](bipy)} n ( 2 ), have been hydrothermally synthesized and characterized by single‐crystal X‐ray diffraction and IR spectra. Complex 1 crystallizes in the triclinic space group P with a = 6.8826(18) Å, b = 11.202(3) Å, c = 12.295(3) Å, α = 86.854(4)°, β = 85.759(5)°, γ = 72.629(4)° and is a novel folded‐paper‐shaped coordination compound with polymeric sheets formed by the five‐coordinate Zn II centers and bridging pdoa and bipy. Complex 2 crystallizes in the monoclinic space group P 2 1 / c with a = 11.507(2) Å, b = 23.254(5) Å, c = 9.8710(19) Å, β = 96.418(4)° and exhibits a robust three‐dimensional framework with nanosized rectangular channels (11.627 × 11.507 Å). They both display blue fluorescent emission and could be considered as new luminescent materials. In addition, the magnetic properties of complex 2 were investigated and the magnetic susceptibility data were rationally fitted with g = 2.072(5), J = –1.11(4) cm –1 , and zJ′ =–0.161(7) cm –1 , showing it is an unprecedented luminescent open‐framework antiferromagnet.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Insights into the Redox Properties of Ceria‐Based Oxides and Their Implications in Catalysis (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Editorial Comment (1983)

No AccessJournal of Urology1 Aug 1983Editorial Comment John W. Duckett John W. DuckettJohn W. Duckett More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51126-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 130(2), p. 315 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 130Issue 2August 1983Page: 315 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information John W. Duckett More articles by this author Expand All Advertisement PDF DownloadLoading ...
The battle between HF and UHF RFID (2008)

Recently, much of the focus has been on UHF passive tags compared to the more established HF (13.56 MHz) and LF (125 to 134.2 kHz) technologies. The 860 to 956 MHz range of UHF has attracted most of the R&D investments. All of these are probably due to the Wal-Mart RFID mandate to their suppliers to follow suit using the UHF band for case-level and pallet-level supply-chain tracking.
Highly Stable <scp>l</scp> -Lysine 6-Dehydrogenase from the Thermophile <i>Geobacillus stearothermophilus</i> Isolated from a Japanese Hot Spring: Characterization, Gene Cloning and Sequencing, and Expression (2004)

L-Lysine dehydrogenase, which catalyzes the oxidative deamination of L-lysine in the presence of NAD, was found in the thermophilic bacterium Geobacillus stearothermophilus UTB 1103 and then purified about 3,040-fold from a crude extract of the organism by using four successive column chromatography steps. This is the first report showing the presence of a thermophilic NAD-dependent lysine dehydrogenase. The product of the enzyme catalytic activity was determined to be Delta1-piperideine-6-carboxylate, indicating that the enzyme is L-lysine 6-dehydrogenase (LysDH) (EC 1.4.1.18). The molecular mass of the purified protein was about 260 kDa, and the molecule was determined to be a homohexamer with subunit molecular mass of about 43 kDa. The optimum pH and temperature for the catalytic activity of the enzyme were about 10.1 and 70 degrees C, respectively. No activity was lost at temperatures up to 65 degrees C in the presence of 5 mM L-lysine. The enzyme was relatively selective for L-lysine as the electron donor, and either NAD or NADP could serve as the electron acceptor (NADP exhibited about 22% of the activity of NAD). The Km values for L-lysine, NAD, and NADP at 50 degrees C and pH 10.0 were 0.73, 0.088, and 0.48 mM, respectively. When the gene encoding this LysDH was cloned and overexpressed in Escherichia coli, a crude extract of the recombinant cells had about 800-fold-higher enzyme activity than the extract of G. stearothermophilus. The nucleotide sequence of the LysDH gene encoded a peptide containing 385 amino acids with a calculated molecular mass of 42,239 Da.
Readily processable imide oligomers containing perfluoroisopropylidene connecting units and reactive acetylenic and biphenylene groups: synthesis, curing, and thermal properties (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReadily processable imide oligomers containing perfluoroisopropylidene connecting units and reactive acetylenic and biphenylene groups: synthesis, curing, and thermal propertiesTsutomu Takeichi and J. K. StilleCite this: Macromolecules 1986, 19, 8, 2108–2114Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/ma00162a003https://doi.org/10.1021/ma00162a003research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IMPLANTATION OF INFLATABLE PENILE PROSTHESIS IN PATIENTS WITH SEVERE CORPOREAL FIBROSIS: INTRODUCTION OF A NEW PENILE CAVERNOTOME (1999)

The new cavernotomes along with the high transverse scrotal incision and downsized prostheses resulted in successful implantation in all of our cases. Dilation of fibrotic corpora was easier and quicker with the new cavernotomes because extensive corporeal resection was not necessary. Complications were acceptable for these difficult cases and prosthesis survival is 100% to date.
Coherency Sensitive Hashing (2011)

Coherency Sensitive Hashing (CSH) extends Locality Sensitivity Hashing (LSH) and PatchMatch to quickly find matching patches between two images. LSH relies on hashing, which maps similar patches to the same bin, in order to find matching patches. PatchMatch, on the other hand, relies on the observation that images are coherent, to propagate good matches to their neighbors, in the image plane. It uses random patch assignment to seed the initial matching. CSH relies on hashing to seed the initial patch matching and on image coherence to propagate good matches. In addition, hashing lets it propagate information between patches with similar appearance (i.e., map to the same bin). This way, information is propagated much faster because it can use similarity in appearance space or neighborhood in the image plane. As a result, CSH is at least three to four times faster than PatchMatch and more accurate, especially in textured regions, where reconstruction artifacts are most noticeable to the human eye. We verified CSH on a new, large scale, data set of 133 image pairs.
Synthesis and Biological Effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a New Analogue of Neurotensin that Crosses the Blood−Brain Barrier (2008)

The central administration of neurotensin (NT) or of its C-terminal hexapeptide fragment NT(8-13), produces strong analgesic effects in tests evaluating acute pain. The use of NT-derived peptides as pharmaceutical agents to relief severe pain in patients could be of great interest. Unfortunately, peptides do not readily penetrate the blood-brain barrier. We have observed that the cyclic NT(8-13) analogue, c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012, compound 1), when peripherally administered to mice produced analgesic and hypothermic effects, suggesting the peptide penetrates the blood-brain barrier and functions effectively like a drug. Moreover, dimeric compounds show increased potency compared to their corresponding monomer. We present the synthesis of the cyclic dimer compound 1 (JMV2012). In mice, compound 1 induced a profound hypothermia and a potent analgesia, even when peripherally administered. Compound 1 appears to be an ideal lead compound for the development of bioactive NT analogues as novel analgesics drugs.
<title>Curvature sensing analysis</title> (1994)

F. Roddier has proposed a curvature sensing and modal compensation adaptive optics system, currently under development at the University of Hawaii. Several astronomical groups have shown interest in such a system, including the Gemini 8-m Telescope Project, and wonder how it compares with previously demonstrated slope sensing/zonal correction systems. To begin to address this question, we present in this paper an optimal estimator analysis of curvature sensing, based on the method Wallner developed for slope sensing systems.
Query association for effective retrieval (2002)

We introduce a novel technique for document summarisation which we call query association. Query association is based on the notion that a query that is highly similar to a document is a good descriptor of that document. For example, the user query "richmond football club" is likely to be a good summary of the content of a document that is ranked highly in response to the query. We describe this process of defining, maintaining, and presenting the relationship between a user query and the documents that are retrieved in response to that query. We show that associated queries are an excellent technique for describing a document: for relevance judgement, associated queries are as effective as a simple online query-biased summarisation technique. As future work, we suggest additional uses for query association including relevance feedback and query expansion.
Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development (2003)

Neuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we have inactivated the Erbb2 gene in developing muscle fibers by Cre/Lox-mediated gene ablation. Neuromuscular synapses form in the mutant mice, but the synapses are less efficient and contain reduced levels of acetylcholine receptors. Surprisingly, the mutant mice also show proprioceptive defects caused by abnormal muscle spindle development. Sensory Ia afferent neurons establish initial contact with Erbb2-deficient myotubes. However, functional spindles never develop. Taken together, our data suggest that Erbb2 signaling regulates the formation of both neuromuscular synapses and muscle spindles.
Extracting foreground masks towards object recognition (2011)

Effective segmentation prior to recognition has been shown to improve recognition performance. However, most segmentation algorithms adopt methods which are not explicitly linked to the goal of object recognition. Here we solve a related but slightly different problem in order to assist object recognition more directly - the extraction of a foreground mask, which identifies the locations of objects in the image. We propose a novel foreground/background segmentation algorithm that attempts to segment the interesting objects from the rest of the image, while maximizing an objective function which is tightly related to object recognition. We do this in a manner which requires no class-specific knowledge of object categories, using a probabilistic formulation which is derived from manually segmented images. The model includes a geometric prior and an appearance prior, whose parameters are learnt on the fly from images that are similar to the query image. We use graph-cut based energy minimization to enforce spatial coherence on the model's output. The method is tested on the challenging VOC09 and VOC10 segmentation datasets, achieving excellent results in providing a foreground mask. We also provide comparisons to the recent segmentation method of [7].
國語「這樣（子）」的言談功能與語法化研究 (2002)

The present study explores the versatile functions of zheyang(zi) in Mandarin spoken discourse in relation to its grammaticalization. Six functions are identified, including exophoric, endophoric, quotation marking, interactive, inference marking, and discourse boundary marking uses. Contrary to traditional characterizations which describe zheyang(zi) as a subtype of deixis, which functions to link language to its outside situation, only the exophoric zheyang(zi) performs such canonical context-indexical function. The rest operate mainly on a textual or interactional level. In addition, in terms of referentialness, only exophoric and endophoric uses are referential in that the referent for zheyang(zi) can be found in the context or cotext. Other functions of zheyang(zi) are largely due to speakers’ pragmatic needs and manipulation of discourse. Pragmatic strengthening along with semantic weakening is observed among these uses. The quotation marking zheyang(zi) serves to frame, and thus to highlight the intended quotation, drawing attention from the addressee. The referent of inference marking zheyang(zi) has to be inferred from a logical reasoning process in hearer’s abstract knowledge basis. The interactive zheyang(zi) further extends to an interactional level, as the main concern is the speakers’ communicative needs to be mutually supportive. Finally, the discourse boundary marking zheyang(zi) can be regarded as an extension from the quotation marking function, as they are similar with respect to their typical position at IU boundary and the accompaniment of intonational break. The discourse boundary marking zheyang(zi) typically marks the end of a discourse unit with certain substantial information. Its pragmatic function is even stronger: in addition to marking the end of a discourse unit and thus helping create discourse coherence, it also signals the significance of the information conveyed, thus drawing the addressee’s attention to it.
In addition to the effect of pragmatic strengthening which accounts for the versatile yet interrelated functions of zheyang(zi), this study also finds evidence from subjectification, phonological coalescence due to frequent use, expansion of scope, and fixation of syntagmatic variability, that together bear witness to our claim that in spoken Mandarin, zheyang(zi) is grammaticalized from a demonstrative to a discourse boundary marker.
Size adjustable separation of biologically active molecules (2004)

Separation of biologically active molecules(BAM&apos;s) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to filter desired materials. As a result, a new technology is needed. The objective of this thesis is to contribute towards the development of a new method for separating biologically active molecules in the size range of 0.5 nanometers to 500 nanometers. A normally open diaphragm valve is proposed that can control a gap formed by two flat surfaces. For accurate control of gap height, the valve was designed to ensure that the flat surfaces remain parallel during operation. Modularity was also part of design considerations to address issues of eventual biocompatibility breakdown- specifically protein adsorption. Control of the gap has been achieved to increments of 1.8 nanometers.
Compact FPGA implementations of QUAD (2007)

QUAD [1] is a stream cipher whose provable security relies on the hardness of solving systems of multivariate quadratic equations. This paper explores FPGA implementations of this stream cipher and, more specifically, small area ones. The smallest of our implementations of QUAD requires only 85 slices (2961 GE) on a Virtex 4 Xilinx FPGA, which makes it not only the smallest provably secure stream cipher, but also a very good competitor among conventional stream ciphers: this implementation of QUAD's underlying PRNG results in a 68% improvement over the smallest known AES implementation on FPGA [4].
Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes. (1988)

The cDNA for human beta 2-interferon (IFN-beta 2)/B-cell differentiation factor 2/hepatocyte-stimulating factor was expressed in Escherichia coli to yield a fusion protein which contains the 182 carboxyl-terminal amino acids of IFN-beta 2 fused to a 34-amino acid prokaryotic leader peptide (rIFN-beta 2). When added to cultures of human hepatoma cell line Hep3B2, rIFN-beta 2 as well as preparations of natural IFN-beta 2 enhance secretion of positive acute phase reactants such as alpha 1-antichymotrypsin, complement C3, fibrinogen, and alpha 1-acid glycoprotein and inhibit secretion of albumin, confirming that a protein derived from the IFN-beta 2 gene can have hepatocyte-stimulating factor activity. We have prepared a rabbit polyclonal antiserum to the E. coli-derived human IFN-beta 2 fusion protein. This polyclonal antiserum inhibits the hepatocyte-stimulating and B-cell differentiation activities of appropriate IFN-beta 2 preparations. The anti-rIFN-beta 2 antiserum has been used in immunoprecipitation experiments and in Western blots to help define the secretory proteins derived from the IFN-beta 2 gene in fibroblasts and monocytes. "Uninduced" human FS-4 fibroblasts as well as those induced with interleukin-1 alpha, tumor necrosis factor, or bacterial lipopolysaccharide secrete at least five forms of IFN-beta 2 of apparent molecular mass in the range from 23 to 30 kDa which can be resolved by polyacrylamide gel electrophoresis under denaturing and reducing conditions. The three higher molecular mass forms are not observed when FS-4 cells are induced in the presence of tunicamycin, suggesting that these forms are N-glycosylated (gp28, gp29, and gp30). Although secretion of the two lower molecular mass forms is resistant to tunicamycin, they are labeled by [3H]glucosamine (gp23-gp25). The inclusion of cycloheximide during the [35S]methionine labeling of induced FS-4 cells results in the preferential synthesis and secretion of the 29-kDa triplet. Human monocytes induced with bacterial lipopolysaccharide also secrete several distinct forms of IFN-beta 2 in the size range from 23 to 30 kDa which co-migrate in polyacrylamide gels with those obtained from FS-4 cells. Our observations help relate previous descriptions of multiple forms of hepatocyte-stimulating factor to specific proteins derived from the IFN-beta 2 gene.
Platelet mitochondrial membrane depolarization reflects disease severity in patients with sepsis and correlates with clinical outcome (2014)

In this study, we demonstrated that mitochondrial membrane depolarization in platelets correlates with clinical disease severity in patients with sepsis during the disease course and may be a valuable adjunct parameter to aid in the assessment of disease severity, risk stratification, and clinical outcome.
Metasurfaces based dual wavelength diffractive lenses (2015)

We demonstrate experimentally and by simulations a method for using thin nanostructured plasmonic metasurfaces to design diffractive Fresnel zone plate lenses that focus pairs of wavelengths to a single focal point. The metasurfaces are made of tightly packed cross and rod shaped optical nanoantennas with strong polarization and wavelength selectivity. This selectivity allows multiplexing two different lenses with low spectral crosstalk on the same substrate and to address any superposition of the two colors at the focus of the lenses by controlling the polarization of light. This concept can open the door to use ultrathin diffractive lenses in fluorescence microscopy and in stimulated emission depletion microscopy.
An Ambulatory, Intermediate Term Left Ventricular Assist Device (1989)

A portable, percutaneous, battery-operated left ventricular assist device intended for intermediate and long-term use is described. The system performed satisfactorily in vitro for periods of up to 9 months and in vivo for periods in excess of 3 months. Long-standing hypertension was observed in a 98 day implant with accompanying renal and visceral vascular changes. No evidence of peripheral thromboembolism was seen. Examination of the textured blood pump surface revealed an established biologic lining, characteristic of that previously seen in calves with some evidence of peripheral calcification.