gebhart/patrepeval huggingface dataset:
A putative antipruritic mechanism of the phosphodiesterase‐4 inhibitor E6005 by attenuating capsaicin‐induced depolarization of C‐fibre nerves (2014)

E6005, a potent, selective phosphodiesterase (PDE) 4 inhibitor, has been developed as a novel topical agent of atopic dermatitis (AD). It has been shown to inhibit itching in patients with AD as well in mouse models. To study the mechanism underlying the anti-pruritic effect of E6005, we examined its effect on the activation of dorsal root ganglion (DRG) neurons associated with the itch sensation. Depolarization of DRG neurons by a transient receptor potential vanilloid 1 (TRPV 1) activator, capsaicin was attenuated by E6005 as well as by a 3',5'-cyclic adenosine monophosphate (cAMP) elevator, forskolin. E6005 elevated intracellular levels of cAMP in DRG cells. Taken together, these results suggest that E6005 suppresses TRPV1-mediated C-fibre depolarization through elevation of cAMP levels, thereby exerting an anti-pruritic effect. Thus, E6005 shows the potential to be a new agent for managing pruritus in various skin disorders, including AD.
Sugars and proteins: New strategies in synthetic biology (2009)

Abstract The development of novel methodology for bond-forming processes that are compatible with biomolecules allows the assembly, alteration, or modification of proteins. Such synthetic proteins allow precise insight and investigation of function in a manner that has the potential for almost unlimited diversity.
The Alarm Pheromone of the Mite <i>Suidasia medanensis</i> OUDEMANS, 1924 (Acariformes, Suidasiidae) (1989)

Journal Article The Alarm Pheromone of the Mite Suidasia medanensis OUDEMANS, 1924 (Acariformes, Suidasiidae) Get access Walter Soares Leal, Walter Soares Leal Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasumasa Kuwahara, Yasumasa Kuwahara Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Takahisa Suzuki, Takahisa Suzuki Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuyoshi Kurosa Kazuyoshi Kurosa Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 53, Issue 10, 1 October 1989, Pages 2703–2709, https://doi.org/10.1080/00021369.1989.10869703 Published: 01 October 1989 Article history Received: 21 April 1989 Published: 01 October 1989
Biocompatible polymeric wireless pressure sensor for intraocular pressure sensing application (2011)

Telemetric sensing is a promising method to accomplish non-contact and continuous disease diagnoses. Implantable intraocular pressure (IOP) sensor using wireless telemetric technology is highly desirable. This paper presents a fully integrated SU-8-based passive wireless inductively-coupled pressure sensor, especially designed for IOP sensor. The sensor was microfabricated using biocompatible materials - gold and SU-8 - to form the LC parallel circuit and the pressure sensitive diaphragm. Multi-SU-8-layers were stacked to completely isolate the working circuit from the biological tissue medium. The characterization result of IOP sensor shows that it has relatively high responsivity (683 KHz/mmHg) in the pressure range of 0 – 60 mmHg and has pressure resolution much lower than 1 mmHg in both air and saline medium.
Importance of Chiral Phase-Transfer Catalysts with Dual Functions in Obtaining High Enantioselectivity in the Michael Reaction of Malonates and Chalcone Derivatives (2005)

[reaction: see text]. Highly enantioselective Michael addition of diethyl malonate to chalcone derivatives has been achieved under mild phase-transfer conditions by the successful utilization of N-spiro C(2)-symmetric chiral quaternary ammonium bromide 1 as a catalyst, which possesses diarylhydroxymethyl functionalities as a recognition site for the prochiral electrophile. This simple asymmetric Michael addition process was found to be quite effective for various chalcone derivatives, including those with heteroaromatic substituents.
Speaker identification using a polynomial-based classifier (2003)

A new set of techniques for using polynomial-based classifiers for speaker identification is examined. This set of techniques makes application of polynomial classifiers practical for speaker identification by enabling discriminative training for large data sets. The training technique is shown to be invariant to fixed liftering and affine transforms of the feature space. Efficient methods for new class addition, low-complexity retraining, and identification across large populations are given. The method is illustrated by application to the YOHO database.
Millimeter wave surface resistance of epitaxially grown YBa2Cu3O7−<i>x</i> thin films (1989)

We have measured the surface resistance of two c-axis oriented YBa2Cu3O7−x thin-film samples in a copper host cavity at 86.7 GHz between 4.2 and 300 K. High quality films of 0.6 and 0.4 μm thickness have been grown epitaxially on SrTiO3 by pulsed excimer laser ablation. Their millimeter wave absorption drops sharply at a transition temperature of 86 and 88 K to a corresponding surface resistance at 77 K of 18 mΩ and less than 8 mΩ, respectively. These values exceed the best results on polycrystalline samples and come close to the expectation from classical superconductors. Therefore, applications of high Tc superconductors up to THz frequencies can be envisaged now.
Current Status and Challenges of Endoscopic Treatments for Duodenal Tumors (2018)

Adenomas and intramucosal carcinomas are target lesions for treatment. A preoperative diagnosis has not been established, but unnecessary biopsies increase the difficulty of treatment and should be avoided. Cold snare polypectomy, endoscopic mucosal resection (EMR), and underwater EMR are treatment options for small lesions. Endoscopic submucosal dissection enables secure resection even for large lesions, but it is technically demanding and associated with a higher complication rate. After endoscopic resections, exposure of digestive juices is believed to cause delayed complications. To prevent these complications, several closing and covering methods are proposed, with favorable clinical results. Key message: A treatment method should be chosen based on each patient's situation. With any of the treatment methods, post-resection measures are required to prevent delayed complications. Secure closure of resection wounds seems promising.
Amplification of spontaneous emission in erbium-doped single-mode fibers (1989)

Amplification of spontaneous emission (ASE) in erbium-doped single-mode fiber amplifiers operating at lambda =1.53 mu m is studied theoretically and experimentally. The ASE noise spectra obtained from the theory are found to be in excellent quantitative agreement with the experimental data. The observed changes in ASE spectral shapes under different population inversion conditions are also explained. The model may be used to evaluate the performance of erbium-doped fiber lasers as well as to assess the noise characteristics of erbium-doped fiber amplifiers as applied to wavelength-division multiplexing optical communications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Simple Calibration Procedure for a 2D LiDAR With Respect to a Camera (2019)

This paper proposes a simple calibration procedure for a planar scanning laser rangefinder or a 2D LiDAR with respect to a regular monocular camera, in which a point-like target is utilized to obtain point-to-point correspondences, which can make the calibration problem simple. In the proposed method, a small spherical object is attached to a rod, which is hand-held, and the correspondences are simply and effectively acquired by setting the target in front of the sensors and repeatedly moving the target downward by hand, until the LiDAR captures the target. We also describe possible noise present in the proposed data acquisition process, followed by simulation and real experiment. The simulation study examines the performance of the proposed calibration in the presence of noise, in which the LiDAR parameter estimation is successful unless the noise is excessive. In the real experiment, the proposed calibration is conducted by constructing a real calibration system, where we evaluate the reprojection error of the proposed calibration. In both simulation and experiment, a conventional calibration procedure with a v-shaped board target is also conducted for evaluating the proposed calibration procedure. It is confirmed that the proposed method is more effective in point cloud acquisition and calibration performance.
Using Domain Ontologies for Classification and Semantic Interpretation of Documents (2016)

International audience
United States and Japanese Application of Titanate Coupling Agents in Polyolefins (1981)

Abstract United States and Japanese applications data for titanate coupling agents discussed in this paper help broaden our understanding of a new technology for providing filler and nonextractable plasticizer functionality in polyolefins. Titanate coupling agents react with the filler surface resulting in the formation of nonextractable organic monomolecular layers providing compatabiliza-tion and a molecular bridge between the interface of the inorganic filler and the organic polyolefin matrix.
Java for embedded systems (1998)

Java requires infrastructure to run on embedded devices. This requirement must be traded against the powerful support for dynamic behavior that it offers embedded system developers.
Relationships Between Training Volume, Physical Performance Capacity, and Serum Hormone Concentrations During Prolonged Training in Elite Weight Lifters (1987)

A follow-up study of 1 year was performed on 11 male elite weight lifters. Several parameters including training volume, weight lifting performance, and serum hormone concentrations were measured during seven test occasions. In addition, the same measurements were repeated three times during a 6-week period preceding the primary competition, which took place about 5 months after beginning of the follow-up. The primary findings were observed during the 6-week period from which the first 2 weeks of stressful training was associated with significant decreases (P less than 0.01-0.001) in serum testosterone concentration, in testosterone/cortisol and in testosterone/SHBG ratios, and with a significant (P less than 0.001) increase in serum LH concentration. The individual changes during the stressful training in serum testosterone/SHBG ratio were related (r = .63; P less than 0.05) to the individual changes in the weight lifting result in the clean and jerk lift. During the following "normal" 2-week and reduced 2-week training periods, the concentration of serum testosterone remained unaltered, but serum cortisol and serum LH decreased significantly (P less than 0.05-0.01). During these periods, the serum testosterone/SHBG ratio increased (P less than 0.01). The individual changes during this preparatory 4-week training before the primary competition in serum testosterone/SHBG ratio and the individual changes in the weight lifting result in the clean and jerk lift correlated significantly with each other (r = .68; P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Multi-scale information fidelity approach for full reference image quality assessment (2015)

The Information Fidelity Criterion (IFC) of image assessment metric is based on the statistical mutual information shared by reference image and distorted image. IFC is parameterless and superior to traditional methods. However, human vision system (HVS) is adaptive to different scale feature of image. A multi-scale IFC approach to model the characteristics of HVS was proposed in this paper, in which image was locally filtered by Gaussian dynamic windows ratio to different scales. Finally, assessment scores for different scales were pooled with weight of contrast sensitivity function. Experimental results showed that the performance of the proposed approach was superior to other methods.
New insights on the functions of the guanylyl cyclase receptors (1997)

The discovery of at least 29 genes encoding putative guanylyl cyclases in Caenorhabditis elegans has raised the question as to whether there are numerous receptors yet to be discovered in the mammal. The nematode, however, not only seems ideal to study guanylyl cyclase receptor localization and function, given the large variety of isoforms, but also leads to possible identification of ligands for orphan guanylyl cyclases by the use of genetic and behavioral assays. A recent powerful approach to describe the function of different guanylyl cyclase isoforms in mammals has been the disruption of the corresponding genes in the mouse. A salt resistant elevation of blood pressure, which corresponds to the phenotype of 50% of all human patients with essential hypertension, is observed in mice lacking the GC-A-receptor. Mice missing the GC-C receptor have been shown to be resistant to STa, an E. coli heat-stable enterotoxin, which is largely responsible for travellers diarrhea in adults and mortality due to diarrhea in infants.
Potential applications of fish oils rich in <i>n</i>-3 fatty acids in the palliative treatment of advanced pancreatic cancer (2011)

The palliative treatment of patients with advanced pancreatic cancer (APC) has undergone little advancement in the last 15 years. Novel therapies that have been investigated to extend survival have shown little benefit over existing chemotherapy regimens. Patients with APC often experience significant weight loss, which is one of the primary factors involved in declining quality of life. Recently, the ability of n-3 fatty acid rich oral preparations to attenuate or reverse tumour-related weight loss has been investigated in this patient group with encouraging results. Laboratory investigation has also yielded promising results suggesting a potential direct tumouricidal effect of n-3 fatty acids as well as the putative potentiation of existing chemotherapy regimes. The present review aims to examine the potential applications of fish oils rich in n-3 fatty acids in patients with APC, present a selection of the studies carried out to date and outline avenues of possible further clinical investigation.
Software independent verification and validation: a process perspective (1991)

Article Free Access Share on Software independent verification and validation: a process perspective Authors: Yvonne LaMarr P.P. Texel & Company, Inc., Victoria Plaza, Building 4, Suite 9, 615 Hope Road, Eatontown N.J. P.P. Texel & Company, Inc., Victoria Plaza, Building 4, Suite 9, 615 Hope Road, Eatontown N.J.View Profile , William E. Fravel P.P. Texel & Company, Inc., Victoria Plaza, Building 4, Suite 9, 615 Hope Road, Eatontown N.J. P.P. Texel & Company, Inc., Victoria Plaza, Building 4, Suite 9, 615 Hope Road, Eatontown N.J.View Profile Authors Info & Claims TRI-Ada '91: Proceedings of the conference on TRI-Ada '91: today's accomplishments; tomorrow's expectationsDecember 1991Pages 408–417https://doi.org/10.1145/126551.126593Published:01 December 1991Publication History 0citation304DownloadsMetricsTotal Citations0Total Downloads304Last 12 Months8Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A generic editor (1997)

Article Free Access Share on A generic editor Author: Art Griesser ObjectIntelligence ObjectIntelligenceView Profile Authors Info & Claims OOPSLA '97: Addendum to the 1997 ACM SIGPLAN conference on Object-oriented programming, systems, languages, and applications (Addendum)January 1997 Pages 50–55https://doi.org/10.1145/274567.274577Online:01 January 1997Publication History 0citation177DownloadsMetricsTotal Citations0Total Downloads177Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Pressure-induced dissociation of fluorescein from the anti-fluorescein single-chain antibody 4-4-20 (1993)

Hydrostatic pressure was used to dissociate fluorescein (Fl) from the high-affinity anti-Fl single-chain antibody 4-4-20 (SCA 4-4-20). Fl dissociation was monitored by measuring (1) the shift in the Fl absorption peak, (2) the recovery in Fl fluorescence intensity, which is quenched upon SCA binding, or (3) the decrease in Fl fluorescence polarization. Pressure effects were studied at two different Fl:SCA 4-4-20 molar ratios: 1:1, at which Fl fluorescence quenching was ca. 35% at atmospheric pressure, and 1:5, at which quenching reached 95-97% under the same conditions. In both cases, pressure-induced dissociation was favored by concomitant dilution of protein and ligand. Dissociation constants (KD) at each pressure were calculated on the basis of measurements of Fl fluorescence polarization under pressure. The dependence of KD, and consequently of delta G of dissociation, on pressure permitted calculation of the magnitude of the standard volume change (delta V) involved in the dissociation process. According to this study, delta V of dissociation for the Fl-SCA complex is -50 mL/mol, which corresponds to a 10-times higher value than that found for dissociation of Fl from the intact IgG mAb 4-4-20 [Herron, J. N., Kranz, D. M., Jameson, D. M., & Voss, E. W., Jr. (1986) Biochemistry 25, 4602-4609]. This difference is explained in terms of a higher overall flexibility of unliganded SCA and of a less stable binding site in SCA relative to mAb.(ABSTRACT TRUNCATED AT 250 WORDS)
A study of the bacteria associated with advancing periodontitis in man (1979)

Samples of apical plaque were taken by means of an anaerobic gas-flushed syringe from 21 sites in eight patients. The samples were anaerobically dispersed, diluted and plated and incubated in an atmosphere of 80% N2, 10% H2 and 10% CO2 for 7-21 days. All colonies on plates containing 20-50 isolates were picked, repeatedly restreaked, characterized and identified where possible by a probabilistic computer identification program. The sites were divided into four groups on the basis of clinical features. The significance of differences between bacterial populations in the groups was determined by the Kruskal Wallis and Mann-Whitney U tests, while the Spearman rank correlation coefficient was used to determine the rank correlation of clinical features of diseases and microbial species. The subgingival microbiota in advanced destructive sites was predominated by Gram-negative rods. The microbiota of two young adult patients with generalized extensive bone loss, extensive clinical inflammation and suppuration was dominated by Bacteroides asaccharolyticus and an organism with characteristics consistent with Actinobacillus actinomycetemcomitans. The predominant cultivable microbiota in two patients with extensive bone loss but minimal clinical inflammation was predominated by Bacteroides melaninogenicus ss intermedius and Eikenella corrodens in one patient and E. corrodens and a slow growing fusiform-shaped Bacteroides in a second patient. A third group of four patients demonstrated moderate levels of clinical inflammation and evidence of continued bone loss in the last year. Predominant organisms in this group were more heterogeneous and included B. asaccharolyticus, Fusobacterium nucleatum, the "fusiform" Bacteroides and anaerobic vibrios. Sites with minimal disease in the patients revealed higher proportions of Gram-positive organisms including Rothia dentocariosa, Actinomyces naeslundii and Actinomyces viscosus. A positive rank correlation could be detected between clinical inflammation including suppuration and B. asaccharolyticus and a negative rank correlation between inflammation and E. corrodens.
Monolithic DQPSK Receiver in InP With Low Polarization Sensitivity (2007)

We present a monolithic differential quadrature phase-shift-keying (DQPSK) receiver in InP consisting of a 1times2 coupler, two different-length waveguides, a 2times4 coupler, and four photodetectors. We demonstrate a method to reduce the interferometer polarization sensitivity and show preliminary results of 43-Gb/s DQPSK reception.
Protective effect of sodium-2-mercaptoethanesulfonate on the gastrointestinal toxicity and lethality of cis-diamminedichloroplatinum. (1986)

cis-Diamminedichloroplatinum (cis-platinum) is an effective and widely used antitumor drug. Patients receiving cis-platinum, however, experience very profound and long lasting gastrointestinal symptoms. The role of intestinal mucosal toxicity in the pathogenesis of these symptoms is unclear. In this study we have investigated the thiol-containing compound mesna (sodium-2-mercaptoethanesulfonate) as a potential antidote to cis-platinum-induced gastrointestinal tract damage. In mice, mesna caused a significant reduction in the gastrointestinal toxicity of cis-platinum assessed by electron microscopy, villus recovery rate, and by disaccharidase estimations. Mesna also significantly reduced serum creatinine levels following cis-platinum. Administration of mesna prior (or immediately following) a 67% lethal dose of cis-platinum protected 87-100% of the animals from the lethal effects. The antitumor efficacy of cis-platinum in L1210 leukemia bearing mice was not affected by coadministration of mesna indicating that the protective effect may be tissue specific. In addition this finding indicates that mesna has potential as an agent which may improve the therapeutic index of cis-platinum in clinical practice.
Evaluation, by Noninvasive Methods, of the Effects of Acute Loss of Thyroid Hormones on the Heart (1992)

To evaluate the effects of the acute loss of thyroid hormones on the heart the authors studied 11 women with acute hypothyroidism. The cardiac study was performed by means of electrocardiography (ECG), radionuclide ventriculography (RNV) at rest and under effort, and monodimensional echocardiography (MD-echo) and was repeated with ECG and MD-echo after six months of thyroxine suppressive therapy. The ECG showed a significant prolongation of QT interval and flattening and inversion of T wave with normal heart rate. The MD-echo revealed left ventricular function in the normal range and normal left ventricular dimensions. RNV showed the ejection fraction in the lower normal range at rest, which increased to a smaller extent under effort in comparison with a control group. The ECG performed during suppressive therapy with L-thyroxine yielded normal findings with an increase of heart rate and of R wave amplitude, and the MD-echo showed no significant variations of cardiac function due to the increase of heart rate.