gebhart/patrepeval huggingface dataset:
Dopamine Oxidation and Autophagy (2012)

The molecular mechanisms involved in the neurodegenerative process of Parkinson's disease remain unclear. Currently, there is a general agreement that mitochondrial dysfunction, α-synuclein aggregation, oxidative stress, neuroinflammation, and impaired protein degradation are involved in the neurodegeneration of dopaminergic neurons containing neuromelanin in Parkinson's disease. Aminochrome has been proposed to play an essential role in the degeneration of dopaminergic neurons containing neuromelanin by inducing mitochondrial dysfunction, oxidative stress, the formation of neurotoxic α-synuclein protofibrils, and impaired protein degradation. Here, we discuss the relationship between the oxidation of dopamine to aminochrome, the precursor of neuromelanin, autophagy dysfunction in dopaminergic neurons containing neuromelanin, and the role of dopamine oxidation to aminochrome in autophagy dysfunction in dopaminergic neurons. Aminochrome induces the following: (i) the formation of α-synuclein protofibrils that inactivate chaperone-mediated autophagy; (ii) the formation of adducts with α- and β-tubulin, which induce the aggregation of the microtubules required for the fusion of autophagy vacuoles and lysosomes.
ExpertRank: An Expert User Ranking Algorithm in Online Communities (2009)

As computer-mediated communication services in the Web 2.0 arena, online communities have become very important places for Web users to share knowledge and experiences. One important research issue in online communities is how to find expert users in the community. In this paper, we investigate the expertise that users displayed in online communities, especially in discussion groups and propose an effective expert ranking algorithm, which integrates both discussion thread contents and social network extracted from massive social interactions. We present a vector space model to compute the content relevance part and a PageRank style algorithm for the expert network part. Considering the expert spamming issue caused by mutually referencing in a small group, we modify the original PageRank algorithm and propose a novel ranking algorithm. The two parts are lastly integrated using a cascade strategy. The experimental results show that our so-called ExpertRank algorithm is an effective expert ranking algorithm, which can guarantee that the highly ranked experts are both highly relevant to the specific queries and highly authoritative in corresponding areas.
STUDY ON THE MOLDING CHARCOAL FROM SOLIDIFIED BIOMASS (2002)

This paper introduces the study on equepment and technology to make molding charcoal by use of biomass such as wastes of agriculture and foresty.The result showed that developed BX model carbonating kiln is an ideal device for the carbonation of molding stuffs from all kinds of biomass.Compared with indigenous cellar shaped kiln,the production period is shortened noticeably,the yield is raised,as well as the products match the Japanese standard.
Transgenic Mice for MTCP1 Develop T-Cell Prolymphocytic Leukemia (1998)

T-cell prolymphocytic leukemia (T-PLL) is a rare form of mature T-cell leukemia associated with chromosomal rearrangements implicatingMTCP1 or TCL1 genes. These genes encode two homologous proteins, p13MTCP1 and p14TCL1, which share no similarity with other known protein. To determine the oncogenic role of MTCP1, mice transgenic for MTCP1under the control of CD2 regulatory regions (CD2-p13 mice) were generated. No abnormality was detected during the first year after birth. A late effect of the transgene was searched for in a cohort of 48 CD2-p13 mice aged 15 to 20 months, issued from 3 independent founders. Lymphoid hemopathies, occurring in the three transgenic lines, were characterized by lymphoid cells with an irregular nucleus, a unique and prominent nucleolus, condensed chromatin, a basophilic cytoplasm devoid of granules, and an immunophenotype of mature T cells. The molecular characterization of Tcrb rearrangements demonstrated the monoclonal origin of these populations. Histopathological analysis of the cohort demonstrated early splenic and hepatic infiltrations, whereas lymphocytosis and medullar infiltrations were found infrequently. The engraftment of these proliferations in H2-matched animals demonstrated their malignant nature. Cumulative incidence of the disease at 20 months was 100%, 50%, and 21% in F3, F4, and F7 lines, respectively, and null in the control group. The level of expression of the transgene, as estimated by Western blotting in the transgenic lines correlated with the tumoral incidence, with the highest expression of p13MTCP1 being found in F3 mice. CD2-p13 transgenic mice developed an hemopathy similar to human T-PLL. These data demonstrate that p13MTCP1 is an oncoprotein and that CD2-p13 transgenic mice represent the first animal model for mature T-PLL.
Enabling Technology in Thin Wafer Dicing (2009)

Driven by IC packaging and performance requirements, the die separation process is facing three main trends: Thinner wafers, stronger die and non-Silicon materials. Memory capacity increase, multichip functions and continuous package miniaturization require ultra thin wafer dicing. For IC performance increases, low-K material and other materials (top layers and even substrates) require different dicing methods for efficient and delamination free dicing processes. It is demonstrated that conventional blade dicing has reached the end of its capabilities and does not meet the separation requirements. Particular thin wafer development and the use of Die Attach Film (DAF) have added challenges and restrictions to the dicing technologies. Laser dicing processes have developed and have become the preferred dicing technology. This paper will discuss the various laser dicing technologies introduced for the different segments and will address the specific performances. Using a multibeam laser dicing process add significant advantages to the different solutions.
Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard. (1995)

DNA damage in the cell activates expression of the p53 tumor suppressor gene, whose role is associated with cell arrest in G1 or apoptosis. The aim of this study was to examine the cell cycle position-related changes in expression of p53, as well as induction of apoptosis, in mitogen-stimulated normal human lymphocytes and in human leukemic MOLT-4 cells (which express mutated p53), following DNA damage by the alkylating agent nitrogen mustard. Measurement of p53 expression and DNA content by flow cytometry followed by bivariate analysis of the data made it possible to correlate the drug-induced changes in p53 expression in individual cells with their cell cycle position without the need for cell synchronization. Expression of p53 was detected immunocytochemically using the AB-6 mAb, which reacts with the product of the wild-type p53 tumor suppressor gene and with most of its mutated forms. Exposure of normal lymphocytes to 5 microM nitrogen mustard caused their arrest in G1, an increase in p53 expression which was maximal in such cells, and significant apoptosis in cells located beyond the arrest point (S and G2 + M cells). In contrast, neither arrest in G1 nor significant apoptosis of MOLT-4 cells was seen after administration of either 0.5 or 5 microM nitrogen mustard for up to 24 h, although the drug reduced the rate of cell progression in the S-phase at both concentrations. Expression of p53 was highest for S and G2 + M MOLT-4 cells in response to the nitrogen mustard. Although a severalfold lower level of p53 was detected in lymphocytes compared to MOLT-4 cells prior to drug treatment, the relative increase in p53 expression in response to the drug was 2-fold higher in lymphocytes. These data suggest that DNA damage caused by nitrogen mustard provides a signal that results in stabilization of wild-type p53, preferentially in G1 cells, causes cell arrest in G1, and induces apoptosis of the cells that either were in the S-phase at the time of drug administration and/or escaped G1 arrest. The increase in expression of mutated p53, in response to DNA damage, is unrelated to the cell cycle position, and neither provides a signal for cell arrest in G1 nor a trigger for immediate apoptosis.
Optical characterization of porous silicon embedded with CdSe nanoparticles (1998)

Arrays of a few nanometer-size clusters have been realized using a porous silicon (PS) matrix by filling its pores with CdSe. The photoluminescence (PL) peak from the embedded area of the PS samples with different luminescence stabilizes at 1.79 eV. This has been interpreted as due to emission from the CdSe clusters with an average size of about 3–5 nm. Likewise, the PL and Raman scattering spectra of the pure PS area of the samples have been compared with those obtained from the embedded areas. PL spectra were examined as a function of laser irradiation. Finally, to analyze the possibility of the formation of metal/porous semiconductor contacts, cross-section structures have been observed by scanning electron microscopy in the electron-beam-induced current mode.
Sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO) in a sibling pair with a homozygous p.A467T <i>POLG</i> mutation (2009)

Two siblings who developed fifth-decade-onset, concurrent progressive sensory ataxia, dysarthria, and ophthalmoparesis were found to be homozygous for the p.A467T mutation of the polymerase gamma (POLG) gene. The clinical course in both subjects was progression to severe disability. The enlarging spectrum of sensory ataxic neuropathies associated with mitochondrial DNA (mtDNA) instability and POLG mutations should be recognized and considered in the differential diagnosis of this unusual presentation.
Tracking the Emergence of High Affinity Aptamers for rhVEGF<sub>165</sub> During Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment Using High Throughput Sequencing (2013)

Capillary electrophoresis-systematic evolution of ligands by exponential enrichment (CE-SELEX) is a powerful technique for isolating aptamers for various targets, from large proteins to small peptides with molecular weights of several kilodaltons. One of the unique characteristics of CE-SELEX is the relatively high heterogeneity of the ssDNA pools that remains even after multiple rounds of selection. Enriched sequences or highly abundant oligonucleotide motifs are rarely reported in CE-SELEX studies. In this work, we employed 454 pyrosequencing to profile the evolution of an oligonucleotide pool through multiple rounds of CE-SELEX selection against the target recombinant human vascular endothelial growth factor 165 (rhVEGF165). High throughput sequencing allowed up to 3 × 10(4) sequences to be obtained from each selected pool and compared to the unselected library. Remarkably, the highest abundance contiguous sequence (contig) was only present in 0.8% of sequences even after four rounds of selection. Closer analyses of the most abundant contigs, the top 1000 oligonucleotide fragments, and even the eight original FASTA files showed no evidence of prevailing motifs in the selected pools. The sequencing results also provided insight into why many CE-SELEX selections obtain pools with reduced affinities after many rounds of selection (typically >4). Preferential amplification of a particular short polymerase chain reaction (PCR) product allowed this nonbinding sequence to overtake the pool in later rounds of selection suggesting that further refinement of primer design or amplification optimization is necessary. High affinity aptamers with 10(-8) M dissociation constants for rhVEGF165 were identified. The affinities of the higher abundance contigs were compared with aptamers randomly chosen from the final selection pool using affinity capillary electrophoresis (ACE) and fluorescence polarization (FP). No statistical difference in affinity between the higher abundance contigs and the randomly chosen aptamers was observed, supporting the premise that CE-SELEX selects a uniquely heterogeneous pool of high affinity aptamers.
Development of Alternative On-site Treatment Systems for Wastewater Treatment: A Demonstration Project for Northern Minnesota (1997)

Final Report Submitted to: Minnesota Technology, Inc., Legislative Commission for Minnesota Resources, Electric Power Research Institute; Funding Period July 1995 through June 1997
MMSPEED: multipath Multi-SPEED protocol for QoS guarantee of reliability and. Timeliness in wireless sensor networks (2006)

In this paper, we present a novel packet delivery mechanism called Multi-Path and Multi-SPEED Routing Protocol (MMSPEED) for probabilistic QoS guarantee in wireless sensor networks. The QoS provisioning is performed in two quality domains, namely, timeliness and reliability. Multiple QoS levels are provided in the timeliness domain by guaranteeing multiple packet delivery speed options. In the reliability domain, various reliability requirements are supported by probabilistic multipath forwarding. These mechanisms for QoS provisioning are realized in a localized way without global network information by employing localized geographic packet forwarding augmented with dynamic compensation, which compensates for local decision inaccuracies as a packet travels towards its destination. This way, MMSPEED can guarantee end-to-end requirements in a localized way, which is desirable for scalability and adaptability to large scale dynamic sensor networks. Simulation results show that MMSPEED provides QoS differentiation in both reliability and timeliness domains and, as a result, significantly improves the effective capacity of a sensor network in terms of number of flows that meet both reliability and timeliness requirements up to 50 percent (12 flows versus 18 flows).
The Price of Reform: Cost-Sharing Proposals for the Medicare Home Health Benefit (2000)

Faced with an impending Medicare "crisis," scholars and policymakers have advanced a variety of proposals for reforming the program. This Note critically examines one proposed solution that draws on an established technique of health policy and insurance-beneficiary cost-sharing-to reduce expenditures in the rapidly-growing Medicare home health program. Recognizing that cost-sharing mechanisms might generate some savings, the author ultimately rejects these proposed remedies in light of their inequitable consequences and practical /imitations. This Note proceeds by establishing a normative framework for assessing cost-sharing proposals. The author then evaluates the normative implications of an array of cost-sharing mechanisms, taking into account the unique demographic and usage characteristics of the beneficiary population. Drawing on empirical research into the effects of cost-sharing on such variables as income and health status, this Note explores the demand response of beneficiaries. The author concludes that cost-sharing likely would be either ineffective or inequitable. In contrast, alternative reform proposals are likely to generate cost-savings without the normative limitations of beneficiary cost-sharing. This Note urges the abandonment of attempts to extend cost-sharing to the home health benefit, and calls for a further exploration of alternative methods to assume the program 's long-term solvency.
Synthesis of benzo[b]thieno‐ and benzo[b]furano‐[2,3‐a]pyrrolo[3,4‐c]carbazole‐5‐, ‐7‐ and ‐5,7‐dione (2001)

Abstract Benzo[b]thieno[2,3‐a]pyrrolo[3,4‐c]carbazoles and benzo[b]furano[2,3‐a]pyrrolo[3,4‐c]carbazoles were prepared from 2‐(2‐benzo[b]thieno)‐ (8) and 2‐(2‐benzo[b]furano)‐3‐[3‐(2,5‐dioxo‐lH‐pyrrolidinyl)]indole (9) by a palladium(II)acetate/tetrachloro‐1,4‐benzoquinone oxidative A‐E ring closure.
High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation. (1992)

Receptor phosphorylation is a key step in the process of desensitization of the beta-adrenergic and other related receptors. A selective kinase (called beta-adrenergic receptor kinase, beta ARK) has been identified which phosphorylates the agonist-occupied form of the receptor. Recently the bovine beta ARK cDNA has been cloned and the highest levels of specific mRNA were found in highly innervated tissues. It was proposed that beta ARK may be primarily active on synaptic receptors. In the present study, the cDNA of human beta ARK was cloned and sequenced. The sequence was very similar to that of the bovine beta ARK (the overall amino acid homology was 98%). Very high levels of beta ARK mRNA and kinase activity were found in peripheral blood leukocytes and in several myeloid and lymphoid leukemia cell lines. Since agonist-induced beta ARK translocation is considered the first step involved in beta ARK-mediated homologous desensitization, we screened a number of G-protein-coupled receptor agonists for their ability to induce beta ARK translocation. In human mononuclear leukocytes, beta-AR agonist isoproterenol and platelet-activating factor were able to induce translocation of beta ARK from cytosol to membrane. After 20 min of exposure to isoproterenol (10 microM), the cytosolic beta ARK activity decreased to 61% of control, while membrane-associated beta ARK activity increased to 170%. 20-min exposure to platelet-activating factor (1 microM) reduced the cytosolic beta ARK activity to 42% of control with concomitant increase in membrane beta ARK activity to 214% of control. The high levels of beta ARK expression in human peripheral blood leukocytes together with the ability of isoproterenol and platelet-activating factor to induce beta ARK translocation, suggest a role for beta ARK in modulating some receptor-mediated immune functions.
Mobile App Tagging (2016)

Mobile app tagging aims to assign a list of keywords indicating core functionalities, main contents, key features or concepts of a mobile app. Mobile app tags can be potentially useful for app ecosystem stakeholders or other parties to improve app search, browsing, categorization, and advertising, etc. However, most mainstream app markets, e.g., Google Play, Apple App Store, etc., currently do not explicitly support such tags for apps. To address this problem, we propose a novel auto mobile app tagging framework for annotating a given mobile app automatically, which is based on a search-based annotation paradigm powered by machine learning techniques. Specifically, given a novel query app without tags, our proposed framework (i) first explores online kernel learning techniques to retrieve a set of top-N similar apps that are semantically most similar to the query app from a large app repository; and (ii) then mines the text data of both the query app and the top-N similar apps to discover the most relevant tags for annotating the query app. To evaluate the efficacy of our proposed framework, we conduct an extensive set of experiments on a large real-world dataset crawled from Google Play. The encouraging results demonstrate that our technique is effective and promising.
Algorithms for concurrent processors (1984)

We are on the verge of a revolution in computing, spawned by advances in computer technology. Progress in very-large-scale integration is leading not so much to faster computers, but to much less expensive and much smaller computers—computers contained on a few chips. These machines, whose cost-effectiveness is expected to be staggering, will make it practical to build very-high-performance computers, or “supercomputers,” consisting of very many small computers combined to form a single concurrent processor.
Design of Magnetic Bearings for Rotor Systems With Harmonic Excitations (1991)

Abstract This paper presents a method for calculating the control forces and the bearing stiffness and damping coefficients to control the response of multi-mass flexible rotor systems mounted on magnetic bearings and subjected to unbalance or harmonic excitation forces. The capability for inclusion of hydrodynamic bearings is retained to model seal effects or to permit the design of magnetic bearings for hybrid systems. Control forces at the magnetic bearing locations are evaluated based on the desired shaft response specified by the modal coordinates. These forces are determined such that the error between the desired response and the achieved response is minimized in a least-square sense. Equivalent bearing coefficients are calculated from the control forces and the achieved response, which when superimposed on the nominal bearing coefficients yield the resultant magnetic bearing coefficients required for control. An example case is presented where control of rotor response has been attempted at the first and the second unbalance critical speeds. The results demonstrate appreciable improvement in response using magnetic bearings.
THE PHYSIOLOGICAL ECOLOGY OF REPTILIAN EGGS AND EMBRYOS. AND THE EVOLUTION OF VIVIPARITY WITHIN THE CLASS REPTILIA (1977)

SUMMARY 1. Eggs of Crocodilia and Chelonia, like those of birds, have a pair of egg membranes separating a thick layer of albumen from the calcareous shell. In contrast, eggs of oviparous Lepidosauria have only a single shell membrane, upon which relatively small amounts of calcium carbonate are deposited; and the volume of albumen in eggs is extraordinarily small at the time of oviposition. 2. With the possible exception of certain geckos and some chelonians, eggs of oviparous reptiles seem always to absorb water from the substrate during the course of normal incubation. In so far as the rate of water absorption exceeds the rate of water loss by transpiration from exposed surfaces, the eggs swell during incubation. The term ‘cleidoic’ cannot be used to describe eggs of this type. 3. Embryos of lizards and snakes influence the water potential of extra‐embryonic fluids contained within their eggs, thereby maintaining or increasing the gradient in water potential that drives water absorption. 4. Embryos of Crocodilia and Chelonia obtain a substantial portion of the calcium used in ossification of skeletal elements from the inner surfaces of the eggshell. In contrast, embryonic lizards and snakes draw upon extensive reserves of calcium present in the yolk, and obtain little (if any) calcium from the eggshell. 5. All reptilian embryos seem to produce substantial quantities of urea as a detoxification product of protein catabolism. Contrary to expectation, uricotelism may not be common among reptilian embryos, even in those few instances where development takes place within a hard, calcareous egg. 6. In eggs of Crocodilia and Chelonia, respiratory gases seem to pass by diffusion through pores in the calcareous eggshell and through spaces between the fibres of the pair of egg membranes. No pores have been observed in the shell of lepidosaurian eggs, and so gases presumably diffuse between the fibres of the single (multilayered) shell membrane. 7. Metabolism of reptilian embryos is temperature‐dependent, as is true for most ectothermic organisms. For each species, there appears to be a particular temperature at which embryonic development proceeds optimally, and departures from this optimum elicit increases in developmental anomalies and/or embryonic mortality. 8. Viviparity has evolved on numerous occasions among species of the Squamata, but seemingly never among Crocodilia or Chelonia. Since the evolution of viviparity entails a progressive reduction in the eggshell, only those organisms whose embryos do not depend upon the eggshell as a source of calcium may have the evolutionary potential to become viviparous. 9. Evolutionary transitions from oviparity to viviparity could have been driven by selection related to (i) thermal benefits to embryos consequent upon retention of eggs within the body of a parent capable of behavioural thermoregulation; (ii) protection of the eggs from nest predators and/or soil microbes; and (iii) more effective exploitation of a seasonal food resource by early emerging young.