gebhart/patrepeval huggingface dataset:
Ag-doped Ti-RH-MCM-41 synthesis using rice husk silica and its antibacterial efficiency (2019)

Abstract Ag-Ti-RH-MCM-41 samples were prepared via rice husk silica with in-situ (one-pot) and ex-situ (sequence) methods to improve the antibacterial property on RH-MCM-41 and Ti-RH-MCM-41. Thus, this work proposed to investigate the antibacterial property of these materials using gram-negative Escherichia coli (E. coli) and gram-positive Staphylococcus aureus (S. aureus) and compared with TiO 2 (rutile), RH-MCM-41 and Ti-RH-MCM-41. The XRD represented MCM-41 showed the broad peak of 100 at 2 theta equal to 2.2° after adding Titanium and Silver on RH-MCM-41. The XRD spectrum represented Titanium and Silver showed the characteristic peaks of anatase TiO 2 but Ag nanoparticles (AgNPs) diffraction peaks did not clearly present in Ag-Ti-RH-MCM-41 (in-situ). On the other hand, the XRD spectrum of Ag-Ti-RH-MCM-41 (ex-situ) presented the small peaks of AgNPs according to the formation of AgNPs during calcination. Antibacterial efficiency of samples was tested via inhibited zone test (clear zone). The Ag-Ti-RH-MCM-41 (in-situ) and Ag-Ti-RH-MCM-41 (ex-situ) exhibited the antibacterial against while RH-MCM-41 and Ti-RH-MCM-41 did not present the antibacterial performance. Thus, Ag-doped Ti-RH-MCM-41 can improve the antibacterial property on RH-MCM-41 and Ti-RH-MCM-41.
Exact Mean Integrated Squared Error (1992)

An exact and easily computable expression for the mean integrated squared error (MISE) for the kernel estimator of a general normal mixture density, is given for Gaussian kernels of arbitrary order. This provides a powerful new way of understanding density estimation which complements the usual tools of simulation and asymptotic analysis. The family of normal mixture densities is very flexible and the formulae derived allow simple exact analysis for a wide variety of density shapes. A number of applications of this method giving important new insights into kernel density estimation are presented. Among these is the discovery that the usual asymptotic approximations to the MISE can be quite inaccurate, especially when the underlying density contains substantial fine structure and also strong evidence that the practical importance of higher order kernels is surprisingly small for moderate sample sizes.
Relaxed hierarchical power/ground grid analysis (2005)

This paper proposes a novel hierarchical approach to the efficient analysis of large VLSI power/ground grids. Different from the existing hierarchical approach where sub-circuit equivalent models are sparsified with computation-intensive integer programming and the resulting modeling may lead to larger errors if the top circuit matrix has large condition number, the new approach employs an iterative (relaxation) procedure to explicitly compensate the errors and avoid introducing dense matrix caused by the circuit reduction. We also propose an efficient scheme for partitioning high performance center-bumped P/G grids. Experimental results demonstrate that the new algorithm is more accurate than the existing hierarchical method while delivering more speedup over the flat simulators.
Challenges and architectural approaches for authenticating mobile users (2008)

This paper casts an architectural eye at existing work on security and privacy in mobile computing. Specifically, it focuses on authentication as it leads up to access control from two points of view: servicer providers granting access to users, and users granting access to service providers. The paper identifies three classes of problems addressed by existing work. Then, it teases out architectural patterns being used to address those problems, their assumptions, properties, and remaining challenges.
Synthesis of 5-hydroxyalkylpyrimidines from lactones. III. 5-Dihydroxycyclopentylpyrimidines (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 5-hydroxyalkylpyrimidines from lactones. III. 5-DihydroxycyclopentylpyrimidinesJohn D. Fissekis and Barbara M. CreeganCite this: J. Org. Chem. 1967, 32, 11, 3595–3603Publication Date (Print):November 1, 1967Publication History Published online1 May 2002Published inissue 1 November 1967https://pubs.acs.org/doi/10.1021/jo01286a066https://doi.org/10.1021/jo01286a066research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proteomic Dissection of Cell Type-Specific H2AX-Interacting Protein Complex Associated with Hepatocellular Carcinoma (2009)

The replacement histone variant H2AX senses DNA double-strand breaks (DSBs) and recruits characteristic sets of proteins at its phosphorylated (gamma-H2AX) foci for concurrent DNA repair. We reasoned that the H2AX interaction network, or interactome, formed in the tumor-associated DNA DSB environment such as in hepatocellular carcinoma (HCC) cells, where preneoplastic lesions frequently occur, is indicative of HCC pathogenic status. By using an in vivo dual-tagging quantitative proteomic method, we identified 102 H2AX-specific interacting partners in HCC cells that stably expressed FLAG-tagged H2AX at close to the endogenous level. Using bioinformatics tools for data-dependent network analysis, we further found binary relationships among these interactors in defined pathway modules, implicating H2AX in a multifunctional role of coordinating a variety of biological pathways involved in DNA damage recognition and DNA repair, apoptosis, nucleic acid metabolism, Ca(2+)-binding signaling, cell cycle, etc. Furthermore, our observations suggest that these pathways interconnect through key pathway components or H2AX interactors. The physiological accuracy of our quantitative proteomic approach in determining H2AX-specific interactors was evaluated by both coimmunoprecipitation/ immunoblotting and confocal colocalization experiments performed on HCC cells. Due to their involvement in diverse functions, the H2AX interactors involved in different pathway modules, such as Poly(ADP-ribose) polymerase 1, 14-3-3 zeta, coflin 1, and peflin 1, were examined for their relative H2AX binding affinities in paired hepatocytes and HCC cells. Treatment with the DSB-inducing agent bleomycin enhanced binding of these proteins to H2AX, suggesting an active role of H2AX in coordinating the functional pathways of each protein in DNA damage recognition and repair.
Longevity of protective immunity to experimental bovine herpesvirus-1 infection following inoculation with a combination modified-live virus vaccine in beef calves (2005)

Results suggest that this combination vaccine provided protection from infection with virulent BHV-1 and significantly reduced nasal shedding of the virus for at least 126 days after vaccination.
Current Situation and Path of Ideological and Political Theory Course in Colleges (2020)

This paper summarizes the ideological and political theory courses in colleges, analyzes the problems in the teaching of ideological and political theory courses in colleges, and puts forward the implementation path of ideological and political theory courses in colleges.The ideological and political theory course in colleges is an awkward position for a long time. Many of our students even directly call the ideological and political theory course a preaching course. The students’ recognition of the course we carry out is not high, and the feedback effect is not good. In essence, the process of ideological and political education is a complex process of movement with many factors interacting, which is full of various contradictions. The basic contradiction is the contradiction between the ideological and moral requirements of a certain society and the ideological and moral level of the educatee.
Catalytic Azide Reduction in Biological Environments (2012)

In the quest for the identification of catalytic transformations to be used in chemical biology and medicinal chemistry, we identified iron(III) meso-tetraarylporphines as efficient catalysts for the reduction of aromatic azides to their amines. The reaction uses thiols as reducing agents and tolerates water, air, and other biological components. A caged fluorophore was employed to demonstrate that the reduction can be performed even in living mammalian cells. However, in vivo experiments in nematodes (Caenorhabditis elegans) and zebrafish (Danio rerio) revealed a limitation to this method: the metabolic reduction of aromatic azides.
Lokale Antibiotikatherapie (2017)

The treatment of superficial wound infections with local antibiotics is considered to be problematic as it is accompanied by an increased risk of resistance development and ineffectiveness in deeper regions. On the contrary, the local application of antibiotics is useful in arthroplasty and necessary if implants are utilized. The reason for this is the prevention of a rapid biofilm formation on foreign implants and a resulting infection may remain undiscovered until it becomes chronic. Apart from exogenous material, necrotic tissue (e. g. bone sequestra) provides suitable retreat areas for pathogens in the body. Because of the characteristics of bone and joint infections and an exceptional infection recurrence rate, a combined approach is required. Systemic antibiotic prophylaxis is able to reduce the number of pathogens acquired by perioperative contamination or hematogenic spread from another focus of infection; however, systemically applied antibiotics often fail to form an effective colonization barrier around the implant because their ability to penetrate the bone is relatively low. On the other hand, the high concentration of locally released antibiotics leads to an effective protection of the implant from bacteria in situ. Thus, for the treatment of implant-associated infections, systemic and local application of anti-infective agents is a reliable adjuvant measure that improves the therapeutic success. Polymethylmethacrylate (PMMA) bone cement is the most commonly used local drug carrier. Based on clinical and microbiological results, microbiologists and infectious disease experts together with the surgeon and pharmacist determine which anti-infective agents are indicated for systemic and local, PMMA cement-related application. Because there is no evident concept for the local application, unlike the recommendation for systemic use of anti-infective agents, this review article describes which aspects should be taken into account.
An experimental study on bit rate reduction and high density recording for a home-use digital VTR (1988)

A description is given of a prototype home digital videotape recorder (DVTR) used for experimentally studying the problems of bit rate reduction while providing high density recording. The authors report on a system adopted that combines two bit rate reducing methods: interfield sub Nyquist sampling and the Hadamard transformation with vector quantization of the resulting joint energy distribution. Using several approaches to high density recording, the prototype system achieved an area packing density of 135 Mb/in./sup 2/ and a linear packing density of 109 Kb/in. at a tape speed of 3.75 m/s. This system is currently capable of one hour recording/reproducing and the feasibilities of two hour recording/reproducing with an area packing density of 270 Mb/in./sup 2/, a linear packing density of 109 kb/in. and a track pitch of 10.3 mu m, were experimentally confirmed by using the same experimental DVTR.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The All-Polyethylene Tibial Component in Primary Total Knee Arthroplasty (2010)

Outcomes of total knee arthroplasties performed with modern all-polyethylene tibial components have been found to be comparable with or better than those of arthroplasties done with metal-backed modular components in numerous mid-to-long-term follow-up studies, radiostereometric analyses, and the few prospective randomized trials available. Advantages of an all-polyethylene tibial component over a metal-backed modular component include lower cost, avoidance of locking-mechanism issues and backside wear, and increased polyethylene thickness after identical bone resections. Disadvantages of an all-polyethylene tibial component compared with a metal-backed modular component include a lack of modularity, limiting intraoperative options; no option for liner removal in the setting of acute irrigation and débridement; and no option for late liner exchange. Primary total knee arthroplasty with a modern all-polyethylene design can be done in many patients, with substantial cost savings across the health-care system.
Computer-Based Cognitive Training in Aging (2016)

At present there is a rapid growth of aging population groups worldwide, which brings about serious economic and social problems. Thus, there is considerable effort to prolong the active life of these older people and keep them independent. The purpose of this mini review is to explore available clinical studies implementing computer-based cognitive training programs as intervention tools in the prevention and delay of cognitive decline in aging, with a special focus on their effectiveness. This was done by conducting a literature search in the databases Web of Science, Scopus, MEDLINE and Springer, and consequently by evaluating the findings of the relevant studies. The findings show that computerized cognitive training can lead to the improvement of cognitive functions such as working memory and reasoning skills in particular. However, this training should be performed over a longer time span since a short-term cognitive training mainly has an impact on short-term memory with temporary effects. In addition, the training must be intense to become effective. Furthermore, the results indicate that it is important to pay close attention to the methodological standards in future clinical studies.
Age-Related Psychophysical Changes and Low Vision (2013)

When considering the burden of visual impairment on aging individuals and society at large, it is important to bear in mind that vision changes are a natural aspect of aging. In this article, we consider vision changes that are part of normal aging, the prevalence of abnormal vision changes caused by disorders of the visual system, and the anticipated incidence and impact of visual impairment as the US population ages. We then discuss the services available to reduce the impact of vision loss, and the extent to which those services can and should be improved, not only to be better prepared for the anticipated increase in low vision over the coming decades, but also to increase the awareness of interactions between visual impairment and comorbidities that are common among the elderly. Finally, we consider how to promote improved quality, availability, and acceptance of low vision care to lessen the impact of visual impairment on individuals, and its burden on society.
Pes Cavus and Pes Planus (1987)

The arch of the foot serves as an adaptable, supportive base for the entire body. This article discusses how the arch of the foot affects the normal biomechanics of the lower limb. An anatomical overview of the three components of the arch of the foot is presented, identifying the medial longitudinal arch as the arch mainly responsible for related structural problems throughout the lower limb. Deviations in the normal structure of the medial longitudinal arch produce unbalanced, functionally unstable conditions of the foot such as pes cavus or pes planus. Specific evaluation criteria for both pes cavus and pes planus are discussed, in addition to the adverse effects these two disorders have on weight bearing, force dissipation, and normal gait. Compensatory pronation associated with pes planus is one of the most common lower extremity disorders seen currently by physical therapists working in sports medicine, and its causes and related lower limb disorders are discussed. Most of these structural deformities can be corrected through the use of various orthotic devices. Specific guidelines are presented for using both soft and permanent orthoses, which offer the foot increased shock absorption and proper structural alignment.
A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients (1995)

Current knowledge of hepatitis B virus (HBV) sequence heterogeneity is based mainly on sequencing of amplified subgenomic HBV fragments. Here, we describe a method which allows sensitive amplification and simplified functional analysis of full-length HBV genomes with or without prior cloning. By this method, a large number of HBV genomes were cloned from sera of six immunosuppressed kidney transplant patients. Two size classes of HBV genomes, one 3.2 kb and another about 2.0 kb in size, were found in all patients. The genome population from one serum sample was studied in detail by size analysis of subgenomic PCR fragments and sequencing. Regions with deletions and insertions were mapped in the C gene and pre-S region. Up to 100% of HBV genomes in all other immunosuppressed patients also had deletions in the C gene. Our results demonstrate the potential of the established method for the structural and functional characterization of heterogeneous populations of complete virion-encapsidated HBV DNAs and suggest that HBV genomes with C gene deletions can have a selective advantage in immunosuppressed patients.
Induction of cyclooxygenase-2 by parathyroid hormone in human osteoblasts in culture. (1997)

These results show that PTH induces COX-2 expression in human osteoblasts in culture and suggest that this isoenzyme is the main factor in the control of prostaglandin synthesis in these experimental conditions.
Physical and chemical properties and stability of sodium cefazolin in buffered eye drops determined with HPLC method. (2012)

The aim of the studies was to analyze the stability of 1% and 5% eye drops containing sodium cefazolin, prepared in citrate buffer of pH 6.11-6.27, which were stored at the temperature of 4 degrees C and 20 degrees C with light protection. The drops were prepared under aseptic conditions by dissolving sodium cefazolin (Biofazolin, IBA Bioton), dry injection form of the drug, in citrate buffer. The viscosity of the drops was increased using polyvinyl alcohol. The drops were preserved with phenylmercuric borate of 0.001% concentration mixed with beta-phenylethyl alcohol of 0.4% concentration in the drops. The concentration of cefazolin was determined at every three days using HPLC method. Besides, the measurements of pH, osmotic pressure and viscosity were performed as well as the organoleptic analysis of the drops (clarity, color, odor). The concentration of cefazolin in 1% drops after the 30-day-storage at the temperature of 4 degrees C, depending on their composition, decreased in the range of 2.17-6.02%. In 5% drops the decrease in cefazolin concentration was similar, i.e., after 30-day-storage at the temperature of 4 degrees C it was 1.62-6.76%. In 1% and 5% drops stored at the temperature of 20 degrees C the stability of the drops determined as the 10% degradation time of cefazolin was in the range of 9-15 days.
Single proline substitutions in predicted alpha-helices of murine granulocyte-macrophage colony-stimulating factor result in a loss in bioactivity and altered glycosylation. (1991)

Contributions of alpha-helices to biological activity in murine granulocyte-macrophage colony-stimulating factor were analyzed using site-directed mutagenesis and protein expression in COS-1 cells. A series of single proline substitutions were made for residues within the four predicted alpha-helices as a means of disrupting local helical secondary structure. Mutations in three of the four helices resulted in marked reductions in bioactivity. Five mutants E21P, L56P, E60P, L63P, and L107P showed 10(2)-10(4)-fold reduction in bioactivity as well as hyperglycosylation. The same Pro substitutions made on non-N-glycosylated molecules had a similar loss in bioactivity implying that a Pro-induced structural change and not hyperglycosylation was responsible for the major decrease in bioactivity. Additional amino acid substitutions at these residues which conserved charge or hydrophobicity, or replaced the original residue with an Ala, verified that conformational changes in the protein structure were specifically due to steric constraints imposed by the Pro residue rather than loss of important side chain functions.
Late onset Alzheimer&rsquo;s disease in older people (2010)

Dementia has become a common diagnosis in aging populations, and the numbers will increase in the forthcoming years. Alzheimer's disease (AD) is the most common form of dementia in the elderly, accounting for 50%-56% of cases at autopsy and in clinical series. Nowadays, the number of people affected by AD is rapidly increasing, and more than 35 million people worldwide have AD, a condition characterized by deterioration of memory and other cognitive domains, and leading to death 3-9 years after diagnosis. The number of patients with AD, the most common cause of disability in the elderly, is set to rise dramatically. Therefore, it is important for clinicians to recognize early signs and symptoms of dementia and to note potentially modifiable risk factors and early disease markers.
Effects of Fibroblast Growth Factors on Deoxyribonucleic Acid and Collagen Synthesis in Rat Parietal Bone Cells* (1989)

Acidic fibroblast growth factor (aFGF) and basic FGF (bFGF) are related molecules that are extractable from bone matrix and may be important in the maintenance of normal bone physiology. The influence of each agent on DNA and protein synthesis was studied using bone-derived primary cell cultures. Both forms of FGF were relatively more mitogenic for bone cell populations with fewer osteoblastic (Ob) characteristics than for Ob-enriched cultures. However, in the Ob cultures, bFGF was intrinsically 10-fold more stimulatory than aFGF, whereas heparin enhanced the mitotic response only to aFGF. An optimal dose of either aFGF or bFGF (100 ng/ml) decreased alkaline phosphatase activity and increased the rate of noncollagen and collagen protein synthesis in Ob cultures. The stimulatory effect was relatively greater on noncollagen than on collagen synthesis, which resulted in a decrease in percent collagen synthesis. Neither factor altered the rate of collagen degradation. Furthermore, hydroxyurea diminished, but did not prevent, the stimulatory effect of each factor on rates of protein synthesis. In contrast, polyacrylamide gel analysis of newly synthesized protein and Northern blot analysis of steady state alpha 1 type I procollagen mRNA indicated differential effects by each agent on procollagen synthesis and processing. These studies suggest that the FGFs may produce their effects on Ob cells through both shared and disparate mechanisms, with the net result being a decrease in the expression of the osteoblastic phenotype.