gebhart/patrepeval huggingface dataset:
Pathogenesis of Diabetic Vascular Disease: Evidence for the Role of Reduced Heparan Sulfate Proteoglycan (1997)

Insulin-dependent diabetic patients with increased urinary albumin excretion are characterized by elevated blood pressure and declining kidney function. In addition, such patients have a high risk of atherosclerotic vascular disease, proliferative retinopathy, and cardiomyopathy, suggesting that albuminuria is a marker of widespread vascular dysfunction. Increased transport of macromolecules across the vascular wall, elevated plasma levels of von Willebrand factor, and impaired fibrinolytic capacity have been demonstrated in albuminuric patients. The cause of this vascular vulnerability in susceptible patients is unknown, but increasing evidence has suggested that loss of the proteoglycan heparan sulfate in the vasculature may explain the widespread nature of the disease. Heparan sulfate is important for the glomerular endothelial cell and basement membrane charge densities, the anticoagulant properties of the vessel wall, and the growth regulation of intimal smooth muscle cells. Recent studies have shown that heparin increases the biosynthesis of heparan sulfate in endothelial cell cultures and prevents the characteristic glomerular basement membrane thickening when given to diabetic rats. Moreover, heparin has been shown to reduce albuminuria in patients with incipient diabetic nephropathy. Although increasing evidence supports the hypothesis that loss of heparan sulfate may play a pathophysiological role in the development of diabetic vascular complications, there are still many unresolved problems. What are the mechanisms of action of glycosaminoglycans at the molecular biology level, and how can we select compounds without anticoagulant activity suitable for long-term use in the prevention and treatment of late diabetic complications?
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals (2021)

We analyzed the effects of a single 14-day course of teplizumab treatment on metabolic function and immune cells among participants in a previously reported randomized controlled trial of nondiabetic relatives at high risk for type 1 diabetes (T1D). In an extended follow-up (923-day median) of a previous report of teplizumab treatment, we found that the median times to diagnosis were 59.6 and 27.1 months for teplizumab- and placebo-treated participants, respectively (HR = 0.457, <i>P</i> = 0.01). Fifty percent of teplizumab-treated but only 22% of the placebo-treated remained diabetes-free. Glucose tolerance, C-peptide area under the curve (AUC), and insulin secretory rates were calculated, and relationships to T cell subsets and function were analyzed. Teplizumab treatment improved beta cell function, reflected by average on-study C-peptide AUC (1.94 versus 1.72 pmol/ml; <i>P</i> = 0.006). Drug treatment reversed a decline in insulin secretion before enrollment, followed by stabilization of the declining C-peptide AUC seen with placebo treatment. Proinsulin:C-peptide ratios after drug treatment were similar between the treatment groups. The changes in C-peptide with teplizumab treatment were associated with increases in partially exhausted memory KLRG1<sup>+</sup>TIGIT<sup>+</sup>CD8<sup>+</sup> T cells (<i>r</i> = 0.44, <i>P</i> = 0.014) that showed reduced secretion of IFNγ and TNFα. A single course of teplizumab had lasting effects on delay of T1D diagnosis and improved beta cell function in high-risk individuals. Changes in CD8<sup>+</sup> T cell subsets indicated that partially exhausted effector cells were associated with clinical response. Thus, this trial showed improvement in metabolic responses and delay of diabetes with immune therapy.
Differential contribution of p300 and CBP to regulatory element acetylation in mESCs (2020)

This genomic study sheds light on distinct functions of two important transcriptional regulators in the context of a developmentally relevant cell type. Given the links to both developmental disorders and cancer, we believe that our study may promote new ways of thinking about how these proteins function in settings that lead to disease.
Ultra wide band impulse switching protocols for event and target tracking applications (2011)

This paper presents a novel energy-efficient pulse switching protocol for ultra light-weight wireless network applications. The key idea is to abstract a single pulse, as opposed to multi-bit packets, as the information exchange mechanism. Pulse switching is shown to be sufficient for event and target tracking applications with binary sensing. Target tracking with conventional packet transport can be prohibitively energy-inefficient due to the communication, processing, and buffering overheads of the large number of bits within a packet's data, header, and preambles. The paper presents a joint MAC and Routing architecture for pulse switching with a novel hop-angular event localization. Through analytical modeling and simulation experiments, it is shown that pulse switching can be an effective means for event based networking, which can potentially replace the packet transport when the information to be transported is binary in nature.
In-Vivo Reactions in Some Bioactive Glasses and Glass-Ceramics Granules (1993)

Two different bioactive glasses and one glass-ceramic were implanted as granules for 2 months in rabbit muscle and for 5 months in sheep jaw in order to study the influence of the biological surroundings on the reactions of the materials. Scanning electron microscope and energy dispersive X-ray microanalysis showed that a calcium and phosphorous-rich (CaP) surface layer (adjacent to a silicon rich-layer) forms on both glasses in both implantation sites. The glass-ceramic developed only a CaP layer. A chemical process of degradation was more evident in muscle, even though the implantation time was shorter than that in bone. For all materials, a chemical bond with bone occurs. The amount of new formed bone was different for the three materials. Aging of the most reactive glass is hypothesized to explain a rapid loss of silicon by diffusion, as indicated by infrared spectroscopy.
Nitrosyl complexes of technetium: synthesis and characterization of [TcI(NO)(CNCMe3)5](PF6)2 and Tc(NO)Br2(CNCMe3)3 and the crystal structure of Tc(NO)Br2(CNCMe3)3 (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrosyl complexes of technetium: synthesis and characterization of [TcI(NO)(CNCMe3)5](PF6)2 and Tc(NO)Br2(CNCMe3)3 and the crystal structure of Tc(NO)Br2(CNCMe3)3Karen E. Linder, Alan Davison, John C. Dewan, Catherine E. Costello, and Simin MalekniaCite this: Inorg. Chem. 1986, 25, 12, 2085–2089Publication Date (Print):June 1, 1986Publication History Published online1 May 2002Published inissue 1 June 1986https://pubs.acs.org/doi/10.1021/ic00232a035https://doi.org/10.1021/ic00232a035research-articleACS PublicationsRequest reuse permissionsArticle Views122Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Addressee and Response Selection for Multi-Party Conversation (2016)

To create conversational systems working in actual situations, it is crucial to assume that they interact with multiple agents. In this work, we tackle addressee and response selection for multi-party conversation, in which systems are expected to select whom they address as well as what they say. The key challenge of this task is to jointly model who is talking about what in a previous context. For the joint modeling, we propose two modeling frameworks: 1) static modeling and 2) dynamic modeling. To show benchmark results of our frameworks, we created a multi-party conversation corpus. Our experiments on the dataset show that the recurrent neural network based models of our frameworks robustly predict addressees and responses in conversations with a large number of agents.
ON SYSTEMS OF PLANE REFLECTING SURFACES (1931)

An algebraic method is evolved of finding the coordinates of the image of any point and of the direction of the emergent portion of any given incident ray after reflection at any number of plane reflecting surfaces. Systems of reflectors are classified according to the nature of the self-conjugate region of the field. A method of designing a system having any assigned properties is described. Suitable criteria are given to determine whether with a prismatic system the whole is non-dispersive, and whether total internal reflection takes place at any given surface; also the boundary conditions at each surface are found. The calculations are simple and free from any ambiguity of sign.
Properties of Some Wide-Band Phase-Splitting Networks (1949)

Passive networks that produce polyphase output from single-phase input over wide frequency bands have great practical utility, yet published analysis of their action is incomplete. After reviewing properties of simple branch circuits useful in such networks, an expression is derived for phase difference produced between branches as a function of frequency. This expression is given a remarkably simple form, from which over-all operating properties are evident by inspection, permitting direct circuit design from required performance. General performance and design curves are presented.
Circulating endothelial cells in coronary artery disease. (2010)

we confirmed that CEC count in peripheral blood can be determined by flow cytometry in CAD patients with both AMI and SA. The CEC count in AMI was increased in comparison to healthy subjects and SA patients in one third of all cases. To determine whether CEC count could be used to improve the diagnosis of an acute coronary syndrome in patients with CAD, additional studies in larger patient groups would be required.
A New Data Management System for Ceramic Matrix Composites (2001)

Continuous Fibre Ceramic Composites (CFCC) are tailored for use in high temperature structural applications. With the most recent improvements in processing technologies and despite some limitations with respect to oxidation and/or creep resistance, these materials are now close to industrial applications. To underpin their application potential, CFCCs require dedicated, adequate and efficient material data management tools, which allow fast data access for use in design and analysis. These tools must be adapted to match the CFCC properties and have to account for high elastic anisotropy, damage tolerance and fibre matrix bond strength. The related database has to meet the needs of collaborative research projects and engineering initiatives where mechanical testing activities are carried out among several partners. The Ceramic Matrix Composite database (CMC-DB) developed at the Institute for Advanced Materials of the European Commission has been designed to fulfil the aforementioned requirements. The CMC-DB system can store experimental data from mechanical tests performed according to accepted standards. The relational database is included in PC stand-alone and client/server versions with intelligent user-guidance running under MS Windows. The first release of the CMC-DB is now available. The database system allows data entry and data retrieval for tensile, creep and low cycle fatigue test data and related mandatory source, specimen and material information. The output options are tables, charts and reports. Because many experiments carried out with these materials still occupy the research stage, the CMC-DB can also cope with measurements and data that are not inferred from existing standards stricto-sensu. For instance, multi-axial strain measurements (to be used for the determination of anisotropic elastic constants), stiffness evolution for tensile or creep cyclic tests and test data for constituents (single fibre or fibre bundle) can also be entered.
Simple and Efficient Method for the Halogenation of Oxygenated Aromatic Compounds (2011)

An efficient and mild method for the chlorination and bromination of oxygenated aromatics, with good regioselectivity and excellent yields, using a combination of HX/H2O2/AcOH in petroleum ether is presented. The effect of ultrasound was investigated.
Cognitive radio-based urban wireless broadband in unused TV bands (2010)

This paper describes an approach for providing wireless broadband access in urban areas by deploying the cognitive radio technology operating in geographically unused TV bands. It is shown, through system simulations performed for real-life urban settings, that a wireless network equivalent to that of cellular operators' next generation mobile broadband (based, e.g., on HSPA or LTE) can be rolled out without any investment in new spectrum and at significantly lower infrastructure costs.
Initial evaluation of hidden dynamic models on conversational speech (1999)

Conversational speech recognition is a challenging problem primarily because speakers rarely fully articulate sounds. A successful speech recognition approach must infer intended spectral targets from the speech data, or develop a method of dealing with large variances in the data. Hidden dynamic models (HDMs) attempt to automatically learn such targets in a hidden feature space using models that integrate linguistic information with constrained temporal trajectory models. HDMs are a radical departure from conventional hidden Markov models (HMMs), which simply account for variation in the observed data. We present an initial evaluation of such models on a conversational speech recognition task involving a subset of the SWITCHBOARD corpus. We show that in an N-best rescoring paradigm, HDMs are capable of delivering performance competitive with HMMs.
Energy-efficient antenna sharing and relaying for wireless networks (2002)

We develop energy-efficient transmission protocols for wireless networks that exploit spatial diversity created by antenna sharing: coordinated transmission and/or processing by several distributed radios. We focus on single-user transmission and examine several possibilities for the strategy employed by the assisting radio, or relay, including decoding and forwarding as well as amplifying and forwarding. In each case, we develop receivers based upon maximum-likelihood and/or maximum signal-to-noise ratio criteria, relate their structures, and compare their bit-error probability performance by means of analysis and simulations. We cast single-hop and multihop routing into our framework for comparison purposes. All of our antenna sharing protocols offer diversity gains over single-hop and multihop transmission, and our results suggest that low-complexity amplifying and forwarding is energy-efficient in spite of noise amplification at the relay.
Pharmacologic modulation of inflammatory mediator release by rat mast cells. (1976)

Current knowledge of the mechanism of inflammatory mediator release from mast cells is reviewed with particular reference to the role of cyclic nucleotides and calcium and their interrelationship with one another as defined by studies in highly purified rat peritoneal mast cells. Data are presented indicating an important role for intracellular cAMP and calcium in the mediation or modulation of release, as well as evidence for a close relationship between these two regulatory systems. Releasing agents which clearly act at the level of the plasma membrane (concanavalin A and anti-IgE antibody) are shown to differ from releasing agents that may not (48/80 and the ionophore A23187) in regard to the early cellular cAMP response, dependency of the release reaction on phosphatidyl serine, and kinetics of release. Pharmacologic modulators of release are discussed; these include: PGE1 and theophylline, which raise cAMP and inhibit release; and diazoxide, adenine, and carbachol which lower cAMP and potentiate release. Adenosine was also found to enhance release with marked effects at concentrations in the low nanomolar range.
REVIEWS L'Image littéravre. Position du probléme. Quelques définitions. By MOREAUFRANCOIS. Paris: SEDES. 1982. 128 pp. (1984)

REVIEWS L'Image littéravre. Position du probléme. Quelques définitions. By FRANCOIS MOREAU. Paris: SEDES. 1982. 128 pp. KIRSTEEN ANDERSON KIRSTEEN ANDERSON LONDON Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XXXVIII, Issue 2, April 1984, Pages 246-a–246, https://doi.org/10.1093/fs/XXXVIII.2.246-a Published: 01 April 1984
Geometrical Determination of PDOP (1984)

A method of geometrically determining Position Dilution of Precision (PDOP) is given. The method gives an insight which is lacking in the purely mathematical determination. The method applies to 3-dimensional GPS fixes. With slight modification it can be applied to 2-dimensional GPS fixes, to 2-dimensional hyperbolic fixes, or to 2-dimensional range-range fixes. Practical examples are given, and the results are shown to agree with the purely mathematical determination.
The C-Terminal Amino Acid of the MHC-I Heavy Chain Is Critical for Binding to Derlin-1 in Human Cytomegalovirus US11-Induced MHC-I Degradation (2013)

Derlin-1 plays a critical role in endoplasmic reticulum-associated protein degradation (ERAD) of a particular subset of proteins. Although it is generally accepted that Derlin-1 mediates the export of ERAD substrates from the ER to the cytosol, little is known about how Derlin-1 interacts with these substrates. Human cytomegalovirus (HCMV) US11 exploits Derlin-1-dependent ERAD to degrade major histocompatibility complex class I (MHC-I) molecules and evade immune surveillance. US11 requires the cytosolic tail of the MHC-I heavy chain to divert MHC-I molecules into the ERAD pathway for degradation; however, the underlying mechanisms remain unknown. Here, we show that the cytosolic tail of the MHC-I heavy chain, although not required for interaction with US11, is required for tight binding to Derlin-1 and thus for US11-induced dislocation of the MHC-I heavy chain to the cytosol for proteasomal degradation. Surprisingly, deletion of a single C-terminal amino acid from the cytosolic tail disrupted the interaction between MHC-I molecules and Derlin-1, rendering mutant MHC-I molecules resistant to US11-induced degradation. Consistently, deleting the C-terminal cytosolic region of Derlin-1 prevented it from binding to MHC-I molecules. Taken together, these results suggest that the cytosolic region of Derlin-1 is involved in ERAD substrate binding and that this interaction is critical for the Derlin-1-mediated dislocation of the MHC-I heavy chain to the cytosol during US11-induced MHC-I degradation.
Molecular approaches towards an anti-ras drug. (1987)

The ras proteins have intrinsic biochemical properties that are similar to those of the guanine nucleotide binding regulatory proteins (G-proteins). Increased oncogenic potential results from amino acid substitutions that, by altering either the intrinsic GTPase activity or the GDP/GTP exchange rate, would lead to an increase in the level of the ras-GTP complex. The functional similarity between the ras oncogene proteins and the G-proteins suggests several mechanisms for an anti-ras drug. Anti-ras drugs could act either by retarding the formation of the biologically active GTP complex of the protein or by preventing the ras protein from interacting with its yet-to-be-identified target. Mutagenesis studies of Harvey (Ha) ras have identified the residues involved in GDP and GTP binding, the residues that constitute the epitope for the neutralizing antibody Y13-259 (63-73) and a region (32-40) that is required for effector action. Computer modeling combined with immunological characterization has suggested some structural properties of this putative 'effector' region.
A BiCMOS W-Band 2×2 Focal-Plane Array With On-Chip Antenna (2012)

This paper presents a W-band 2 × 2 focal-plane array (FPA) for passive millimeter-wave imaging in a standard 0.18 μm SiGe BiCMOS process ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> / <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> = 200/180 GHz). The FPA incorporates four Dicke-type receivers representing four imaging pixels. Each receiver employs the direct-conversion architecture consisting of an on-chip slot folded dipole antenna, an SPDT switch, a low noise amplifier, a single-balanced mixer, an injection-locked frequency tripler (ILFT), an IF variable gain amplifier, a power detector, an active bandpass filter and a synchronous demodulator. The LO signal is generated by a shared Ka-band PLL and distributed symmetrically to four local ILFTs. The measured LO phase noise is -93 dBc/Hz at 1 MHz offset from the 96 GHz carrier. This imaging receiver (without antenna) achieves a measured average responsivity and noise equivalent power of 285 MV/W and 8.1 fW/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sup> , respectively, across the 86-106 GHz bandwidth, which results a calculated NETD of 0.48 K with a 30 ms integration time. The system NETD increases to 3 K with on-chip antenna due to its low efficiency at W-band. MMW images have been generated in transmission mode. This work demonstrates the highest integration level of any silicon-based systems in the 94 GHz imaging band.
Analysis of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer<sup>−</sup>xenografts in athymic nude mice (1985)

Among 15 human tumor cell strains from Japanese patients, one strain derived from a patient with thyroid cancer showed inability to support the growth of adenovirus 5 treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). When plated on this Mer- strain, adenovirus 5 showed 3-4 times higher sensitivity to MNNG-induced killing than when plated on any of the other 14 Mer+ tumor cell strains. Biochemical analysis showed that the Mer- strain was defective in demethylation repair of O6-methylguanine produced by MNNG treatment. The sensitivities of 12 of the 15 human tumor strains, including the Mer- strain, to MNNG were compared by measuring their colony-forming abilities. All the strains tested showed the Rem- phenotype (having higher sensitivity to MNNG-produced cell killing than normal fibroblasts). The differential killing effects of MNNG on Mer- and Mer+ tumor cells under in vivo conditions were tested using the Mer+ HeLa S3 strain and its Mer- variant. Mer+ cells and Mer- cells were implanted subcutaneously into the left and right flanks, respectively, of 10 nude mice and the next day, MNNG solution (0.25 ml at 1 mg/ml) was injected into the implantation sites of eight mice. Mer- tumor cells in six of eight treated mice showed no growth and those in the other two mice did grow, but regressed after approximately 3 weeks. In contrast, Mer+ tumor cells continued to grow in all the eight mice treated, indicating that Mer- tumor cells may be selectively inactivated by suitable therapeutic regimens with appropriate methylating drugs.