gebhart/patrepeval huggingface dataset:
Nucleotide sequence of full length human embryonic myosin heavy chain cDNA (1989)

Journal Article Nucleotide sequence of full length human embryonic myosin heavy chain cDNA Get access Mark Eller, Mark Eller Search for other works by this author on: Oxford Academic PubMed Google Scholar Hansell H. Stedman, Hansell H. Stedman 1Department of Human Genetics, Hospital of the University of PennsylvaniaPhiladelphia, PA 19104, USA4Department of Surgery, Hospital of the University of PennsylvaniaPhiladelphia, PA 19104, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar James E. Sylvester, James E. Sylvester 1Department of Human Genetics, Hospital of the University of PennsylvaniaPhiladelphia, PA 19104, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Scott H. Fertels, Scott H. Fertels 2Anatomy, School of Medicine, University of PennsylvaniaPhiladelphia, PA 19104, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Neal A. Rubinstein, Neal A. Rubinstein 2Anatomy, School of Medicine, University of PennsylvaniaPhiladelphia, PA 19104, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan M. Kelley, Alan M. Kelley 3Department of Pathobiology, School of Veterinary Medicine, University of PennsylvaniaPhiladelphia, PA 19104, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Satyapriya Sarkar Satyapriya Sarkar Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 9, 11 May 1989, Pages 3591–3592, https://doi.org/10.1093/nar/17.9.3591 Published: 11 May 1989 Article history Received: 27 March 1989 Published: 11 May 1989
Resolution of dl-α-Hydroxy-β,β-dimethyl-γ-butyrolactone (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResolution of dl-α-Hydroxy-β,β-dimethyl-γ-butyrolactoneRandolph T. Major and Jacob FinkelsteinCite this: J. Am. Chem. Soc. 1941, 63, 5, 1368–1371Publication Date (Print):May 1, 1941Publication History Published online1 May 2002Published inissue 1 May 1941https://pubs.acs.org/doi/10.1021/ja01850a068https://doi.org/10.1021/ja01850a068research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genetic Identification of Nascent Peptides That Induce Ribosome Stalling (2009)

Several nascent peptides stall ribosomes during their own translation in both prokaryotes and eukaryotes. Leader peptides that induce stalling can regulate downstream gene expression. Interestingly, stalling peptides show little sequence similarity and interact with the ribosome through distinct mechanisms. To explore the scope of regulation by stalling peptides and to better understand the mechanism of stalling, we identified and characterized new examples from random libraries. We created a genetic selection that ties the life of Escherichia coli cells to stalling at a specific site. This selection relies on the natural bacterial system that rescues arrested ribosomes. We altered transfer-messenger RNA, a key component of this rescue system, to direct the completion of a necessary protein if and only if stalling occurs. We identified three classes of stalling peptides: C-terminal Pro residues, SecM-like peptides, and the novel stalling sequence FXXYXIWPP. Like the leader peptides SecM and TnaC, the FXXYXIWPP peptide induces stalling efficiently by inhibiting peptidyl transfer. The nascent peptide exit tunnel and peptidyltransferase center are implicated in this stalling event, although mutations in the ribosome affect stalling on SecM and FXXYXIWPP differently. We conclude that ribosome stalling can be caused by numerous sequences and is more common than previously believed.
Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England (2011)

In 2.6% of cases, OPMDs transformed to invasive cancer for a total person follow-up time of 12,273 years (mean 9.04 years). The severity of dysplasia is a significant predictor for malignant transformation.
Effect of vasodilator therapy on mortality in chronic congestive heart failure (1988)

The reduction of mortality in patients with chronic congestive heart failure treated with the vasodilator regimen hydralazine and isosorbide dinitrate compared to those treated with placebo or prazosin in the Veterans Administration Cooperative Study (V-HeFT) was examined in order to explore the possible mechanism of the favourable effect. Similar efficacy in coronary and non-coronary disease patients tends to discount a prominent effect on myocardial perfusion. The most likely explanation for the prolonged survival on the effective vasodilator regimen is that these drugs tend to increase left ventricular ejection fraction, probably by a sustained effect on preload and impedance.
Syntheses of Acyclic Analogs of Didemnin B (1997)

Abstract The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (1st) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine, D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.
Post-quantum RSA. (2017)

This paper proposes RSA parameters for which (1) key generation, encryption, decryption, signing, and verification are feasible on today’s computers while (2) all known attacks are infeasible, even assuming highly scalable quantum computers. As part of the performance analysis, this paper introduces a new algorithm to generate a batch of primes. As part of the attack analysis, this paper introduces a new quantum factorization algorithm that is often much faster than Shor’s algorithm and much faster than pre-quantum factorization algorithms. Initial pqRSA implementation results are provided.
Mechanical Strain-Stimulated Remodeling of Tissue-Engineered Blood Vessel Constructs (2003)

Progress in tissue-engineering research has renewed optimism about the possibility of constructing a physiologically functional blood vessel substitute in the laboratory. To this end, we have explored the use of defined mechanical stimulation to further the development of vascular tissue analogs. We now report our findings on smooth muscle cell and fibroblast-seeded collagen constructs exposed to 10% cyclic strain for 4 or 8 days. Our results demonstrate that 4-day strained constructs exhibit an enhancement of mechanical properties, likely through the remodeling actions of matrix metalloproteinase 2 (MMP-2). Strain-stimulated expression of MMP-2 is accompanied by alterations in elastin and collagen gene expression. In the context of tissue engineering a blood vessel construct, we report that strain-stimulated regulation of MMP-2 activity could have a favorable impact on the structural development of the constructs whereas overexpression of MMP-2 during prolonged exposure to strain (8 days) could have adverse consequences on the structural integrity of the tissue analogs. Taken together, these results illustrate the importance of mechanical stimulus as a major regulatory component of tissue-engineered blood vessel remodeling.
Mixed-integer SOCP formulation of the path planning problem for heterogeneous multi-vehicle systems (2014)

We consider the path planning problem for heterogeneous multi-vehicle systems. In such a setup an agile vehicle, which can move quickly but has limited operating range, is carried by a carrier vehicle that moves slowly but has large range. The objective is to devise an optimal path for the multi-vehicle system such that all desired points are visited as quickly as possible, while respecting all physical constraints. We show how to translate the mixed-integer nonlinear formulation of such a problem into a mixed-integer second-order cone problem that can be solved much more efficiently. The translation process employs basic concepts of propositional logic and is not conservative. Efficacy of the proposed formulation is demonstrated on a large case study.
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis (2014)

Silent information regulator 1 (SIRT1) is involved in a number of cellular regulatory mechanisms affecting cellular life span, stress resistance, apoptosis and cellular metabolism. Recent studies have revealed that SIRT1 plays a dual role as a tumor suppressor and a tumor promoter in multiple stages of carcinogenesis. Increased lipogenesis has been found in cancer cells, sterol regulatory element binding protein 1 (SREBP1) are nuclear lipogenic transcription factors, which mainly regulate lipogenic processes by activating genes involved in fatty acid and triglyceride biosynthesis. In the present study, we detected expression of SIRT1 in endometrial cancer (EC) and illustrated the relationship between SIRT1 and SREBP1, which indicated that SIRT1 could stimulate endometrial tumor growth through the lipogenic pathway. Gene expression levels of SIRT1 were assayed using quantitative real-time PCR and protein expression levels were detected by western blotting. RNA interference was conducted in order to explore the subsequent effect on tumor cells and on the expression of SREBP1. Expression levels of SIRT1 in EC were found to be significantly higher than in normal endometrium. Knockdown of SIRT1 could downregulate expression of SREBP1 and suppress cell proliferation. These results demonstrated that SIRT1 may play a role as a tumor promoter in EC and can promote endometrial tumor growth by promoting lipogenesis. Our findings suggest that targeting SIRT1 may provide a theoretical basis for the management of EC.
Regional structural characteristics of bovine periodontal ligament samples and their suitability for biomechanical tests (2008)

Mechanical testing of the periodontal ligament requires a practical experimental model. Bovine teeth are advantageous in terms of size and availability, but information is lacking as to the anatomy and histology of their periodontium. The aim of this study, therefore, was to characterize the anatomy and histology of the attachment apparatus in fully erupted bovine mandibular first molars. A total of 13 teeth were processed for the production of undecalcified ground sections and decalcified semi-thin sections, for NaOH maceration, and for polarized light microscopy. Histomorphometric measurements relevant to the mechanical behavior of the periodontal ligament included width, number, size and area fraction of blood vessels and fractal analysis of the two hard-soft tissue interfaces. The histological and histomorphometric analyses were performed at four different root depths and at six circumferential locations around the distal and mesial roots. The variety of techniques applied provided a comprehensive view of the tissue architecture of the bovine periodontal ligament. Marked regional variations were observed in width, surface geometry of the two bordering hard tissues (cementum and alveolar bone), structural organization of the principal periodontal ligament connective tissue fibers, size, number and numerical density of blood vessels in the periodontal ligament. No predictable pattern was observed, except for a statistically significant increase in the area fraction of blood vessels from apical to coronal. The periodontal ligament width was up to three times wider in bovine teeth than in human teeth. The fractal analyses were in agreement with the histological observations showing frequent signs of remodeling activity in the alveolar bone - a finding which may be related to the magnitude and direction of occlusal forces in ruminants. Although samples from the apical root portion are not suitable for biomechanical testing, all other levels in the buccal and lingual aspects of the mesial and distal roots may be considered. The bucco-mesial aspect of the distal root appears to be the most suitable location.
Advances and Limitations of Antibody Drug Conjugates for Cancer (2021)

The popularity of antibody drug conjugates (ADCs) has increased in recent years, mainly due to their unrivalled efficacy and specificity over chemotherapy agents. The success of the ADC is partly based on the stability and successful cleavage of selective linkers for the delivery of the payload. The current research focuses on overcoming intrinsic shortcomings that impact the successful development of ADCs. This review summarizes marketed and recently approved ADCs, compares the features of various linker designs and payloads commonly used for ADC conjugation, and outlines cancer specific ADCs that are currently in late-stage clinical trials for the treatment of cancer. In addition, it addresses the issues surrounding drug resistance and strategies to overcome resistance, the impact of a narrow therapeutic index on treatment outcomes, the impact of drug-antibody ratio (DAR) and hydrophobicity on ADC clearance and protein aggregation.
Rectal hydrocortisone during stress in patients with adrenal insufficiency (1998)

Rectal hydrocortisone is a safe alternative to parenteral administration in the self management of Addisonian prone conditions. However, because eight of 57 children did not achieve concentrations > 600 nmol/l, its use is recommended only after previously documenting an adequate serum cortisol concentration three hours after receiving a test dose.
Synthesis of 1<i>H</i>‐naphth[2,3‐<i>d</i>]imidazole‐4,9‐diones by acid catalyzed cyclization of 2‐Acylamino‐3‐amino‐1,4‐naphthoquinones (1969)

Abstract The conversion of 2‐acylamino‐3‐amino‐1,4‐naphthoquinones (II) to the corresponding 2‐substituted 1 H ‐naphth[2,3‐ d ]imidazole‐4,9‐diones (I) under both alkaline and acid catalyzed conditions has been effected and the results compared. Treatment of 3‐(4′‐chlorobutanonyl‐amino)‐3‐amino‐1,4‐naphthoquinone (He) with aqueous ethanolic sodium hydroxide solution gives 1,2‐butanonaphth[2,3‐ d ]imidazole‐4,9‐dione (V); whereas, treatment of lie with refluxing formic acid gave 2‐(4′‐chlorobutyl)‐1 H ‐naphth[2,3‐ d ]imidazole‐4,9‐dione. Treatment of 2‐substi‐tuted 1 H ‐naphth[2,3‐ d ]imidazole‐4,5‐diones in DMF with alkyl halides in the presence of potassium carbonate affords the expected 1,2‐disubstituted naphth[2,3‐d]imidazole‐4,9‐diones (VI). The spectral properties of I, II, V and VI as well as those of some 2‐acylamino‐3‐chloro‐1,4‐naphthoquinones IV are discussed.
Importance of the N-terminal domain of the type II angiotensin antagonist sarmesin for receptor blockade (1988)

Analogues of the competitive angiotensin antagonist [Sar1,Tyr(ME)4]angiotensin II (sarmesin) with modifications at the N-terminus have been prepared by the solid-phase method and purified by reversed-phase HPLC. Substitution of the Sar1 residue of sarmesin with N,N-dimethyl-Gly, N-ethyl-Gly, aminoisobutyric, (methylamino)isobutyric, aminocaproic, and oxamic acids gave analogues that had the following respective antagonist activities (pA2) in the rat isolated uterus assay: less than 6, 6.9, 5.5, 6.0, less than 6, and 5.3. The additional substitution of Ile for Phe at the C-terminus of the latter four peptides gave pA2 values of 7.1, 5.1, less than 5, and 5. Substitution of the Arg2 residue of sarmesin with Nle or Sar abolished antagonist activity. These data emphasize the stringent and discriminating structural requirements in the N-terminal domain of sarmesin that endow this analogue with its antagonist properties and suggest the presence of defined steric constraints in this region of the molecule during receptor blockade.
Subjective and Objective Quality Assessment of Compressed 4K UHD Videos for Immersive Experience (2017)

We present a study of subjective and objective quality assessment of compressed 4K ultra-high-definition (UHD) videos in an immersive viewing environment. First, we conduct a subjective quality evaluation experiment for 4K UHD videos compressed by three state-of-the-art video coding techniques, i.e., Advanced Video Coding, High Efficiency Video Coding, and VP9. In particular, we aim at investigating added values of UHD over conventional high definition (HD) in terms of perceptual quality. The results are systematically analyzed in various viewpoints, such as coding scheme, bitrate, and video content. Second, existing state-of-the-art objective quality assessment techniques are benchmarked using the subjective data in order to investigate their validity and limitation for 4K UHD videos. Finally, the video and subjective data are made publicly available for further research by the research community.
Notice of Retraction: Does Refactoring of Test Smells Induce Fixing Flaky Tests? (2017)

Retracted.
Effect of Electric Fields on Membrane Bound (Na,K)-ATPase (1988)

Abstract : A protein of a cell membrane is structurally sensitive to an electric field because of its charges, helix dipoles and polarizability. When such a protein is exposed to an applied oscillating electric field, the conformational oscillation of the protein can be coupled to driving an endergonic reaction. We have investigated how such an interaction between the sodium, potassium +(Na,K)-ATPase of human erythrocytes and an a.c. field leads to active pumping of K+ and Na against their respective concentration gradient. Experiments done in this past year establish that optimum frequency of rubidium Rb+ (an equivalent of K+) occurs at 1.0 kHz and that for Na+ efflux at 1 MHz or higher. The optimum voltage for both pumps is 20 V/cm. An electroconformational coupling model is proposed and the above data analyzed according to the model. In the continuation years we will study the relationship between stimulating voltage and optimum frequency, and vise versa. Its molecular mechanisms will be investigated and more quantitative analysis performed. Keywords: Electrophysiology; Biochemistry.
Assessment of Ground‐Water Contamination Near Lantana Landfill, Southeast Florida <sup>a</sup> (1988)

ABSTRACT The Lantana landfill located in Palm Beach County rises 40 to 50 feet above normal ground level and consists of about 250 acres of compacted garbage and trash, some below the water table. Surface‐resistivity measurements and water‐quality analyses indicate a contaminant plume along the eastern perimeter of the landfill that has migrated about 300 feet eastward toward an adjacent lake. Concentrations of chloride, ammonia, and nitrate were elevated within the plume. The surficial aquifer consists primarily of sand from 0 to about 68 feet, and sand interbedded with sandstone and limestone from 68 to 220 feet. A slight hydraulic gradient exists, indicating ground‐water movement from the landfill toward a lake to the east. Analyses of geoelectric, lithologic, and water‐quality data indicate that surface geophysical techniques were successful in determining the areal and vertical extent of leachate migration at this location.
Advancements in Salinity Gradient Solar Pond Technology Based on Sixteen Years of Operational Experience (2004)

The El Paso salinity gradient solar pond, initiated in 1983, has been in operation since 1985. Through 16 years of research and operation, the El Paso Solar Pond has successfully demonstrated applications including desalination, waste brine management, industrial process heat production, and electricity generation; and has developed and implemented key technical advancements to improve the technical viability and economic feasibility of salinity gradient solar ponds, including: 1) an automated instrumentation monitoring system, 2) a stability analysis strategy and high temperature (60–90°C) gradient maintenance methods, 3) a scanning injection technique for improved salinity gradient construction and maintenance, 4) new liner technology, and 5) an improved heat extraction system.
Dimensionality analysis of facial signatures in visible and thermal spectra (2015)

Face images are an important source of information for biometric recognition and intelligence gathering. While face recognition research has made significant progress over the past few decades, recognition of faces at extended ranges is still highly problematic. Recognition of a low-resolution probe face image from a gallery database, typically containing high resolution facial imagery, leads to lowered performance than traditional face recognition techniques. Learning and super-resolution based approaches have been proposed to improve face recognition at extended ranges; however, the resolution threshold for face recognition has not been examined extensively. Establishing a threshold resolution corresponding to the theoretical and empirical limitations of low resolution face recognition will allow algorithm developers to avoid focusing on improving performance where no distinguishable information for identification exists in the acquired signal. This work examines the intrinsic dimensionality of facial signatures and seeks to estimate a lower bound for the size of a face image required for recognition. We estimate a lower bound for face signatures in the visible and thermal spectra by conducting eigenanalysis using principal component analysis (PCA) (i.e., eigenfaces approach). We seek to estimate the intrinsic dimensionality of facial signatures, in terms of reconstruction error, by maximizing the amount of variance retained in the reconstructed dataset while minimizing the number of reconstruction components. Extending on this approach, we also examine the identification error to estimate the dimensionality lower bound for low-resolution to high-resolution (LR-to-HR) face recognition performance. Two multimodal face datasets are used for this study to evaluate the effects of dataset size and diversity on the underlying intrinsic dimensionality: 1) 50-subject NVESD face dataset (containing visible, MWIR, LWIR face imagery) and 2) 119-subject WSRI face dataset (containing visible and MWIR face imagery).
Treatment of HIV infection with once-daily regimens (2012)

Nine OD US FDA-approved regimens and one new integrase inhibitor OD regimen have been shown to be efficient and well tolerated. For the fixed-dose single-tablet regimens (STRs), there are two currently approved regimens: Atripla® and Complera®. Another STR elvitegravir/cobicistat/emtricitabine/tenofovir (QUAD, Stribild®) is recently approved by the US FDA (August 20, 2012), whereas two additional SRTs, including abacavir/lamivudine/dolutegravir and darunavir/cobicistat/emtricitabine/GS-7340 are undergoing Phase III and II trials, respectively. Three OD regimens are currently recommended by the US DHHS guidelines as the preferred regimens for treatment-naïve patients (efavirenz, boosted atazanavir and boosted darunavir). EFV-based regimen is the only OD regimen available for resource-limited countries. Nevertheless, it should be noted that each of these OD regimens has its own advantages and disadvantages and therefore should be selected accordingly.
An Introduction to Bioinformatics Algorithms (2004)

In the early 1990s when one of us was teaching his first bioinformatics class, he was not sure that there would be enough students to teach. Although