gebhart/patrepeval huggingface dataset:
Maternal Dietary Zinc Influences DNA Strand Break and 8-Hydroxy-2'-Deoxyguanosine Levels in Infant Rhesus Monkey Liver (1993)

Severe zinc deficiency in rodent models has been shown to influence the frequency of single-strand breaks in DNA isolated from liver. In the current study, we investigated whether DNA isolated from infant monkeys born to mothers fed zinc-restricted diets would be characterized by higher than normal levels of DNA damage. DNA was isolated from 30-day-old infants born to dams fed low zinc (2 or 4 micrograms Zn/g) or control zinc (50 micrograms Zn/g) diets. The amount of single-strand breaks in liver DNA was significantly higher in the low zinc group than in controls; consistent with the above, there was a trend for higher steady state levels of liver 8-hydroxy-2'-deoxyguanosine in the low zinc group. While evidence for DNA damage in the low zinc group was obtained, the activities of several antioxidant enzymes were similar between the low zinc and control groups. In summary, infants born to monkeys fed low zinc diets are characterized by evidence of DNA damage shortly after birth; this damage may be due to an increased rate of oxidative damage and/or a reduction in the rate of DNA repair.
Safety of Anterior Cement Fixation in the Cervical Spine: In Vivo Study of Dog Spine (1984)

There is increased use of methylmethacrylate in the treatment of neoplastic lesions of the spine. The advantage of this treatment is immediate stabilization, thus avoiding prolonged immobilization. In vivo study using a dog model showed that anterior fixation with cement, with or without Gelfoam as insulation material, produced no spinal cord injury.
Early Involutionary Changes in the Post-Ovulatory Follicles of the Ring-Necked Pheasant (1947)

Roland K. Meyer, Cyril Kabat, Irven O. Buss, Early Involutionary Changes in the Post-Ovulatory Follicles of the Ring-Necked Pheasant, The Journal of Wildlife Management, Vol. 11, No. 1 (Jan., 1947), pp. 43-49
A Prospective Population-Based Study of Triggers of Symptomatic Flares in IBD (2010)

This study adds to the growing evidence that psychological factors contribute to IBD symptom flares. There was no support for differential rates of use of NSAIDS, antibiotics, or for the occurrence of (non-enteric) infections related to IBD flares.
An Improved Adhesive Patch for Long-Term Collection of Sweat (1980)

An improved adhesive patch is described, capable of collecting sweat continuously at a steady rate for periods up to ten days. Four normal subjects wore duplicate patches applied to the skin above the outer ankle and the collecting pads were weighed every second day for ten days. Uptake was linear in all patches (r2 = 0.99) and the uptake rate varied from 18.38 to 47.01 mg/day (mean = 27.18 mg/day, equivalent to 0.71 mg/cm2/hour). Several drugs are excreted in the sweat, and this patch has potential applications as a tool to monitor drug-taking behavior.
The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group (2010)

Current therapies for multiple sclerosis effectively reduce inflammation, but do little in terms of repair to the damaged central nervous system. Cell-based therapies may provide a new strategy for bolstering regeneration and repair through neuro-axonal protection or remyelination. Mesenchymal stem cells modulate pathological responses in experimental autoimmune encephalitis, alleviating disease, but also stimulate repair of the central nervous system through the release of soluble factors. Autologous and allogeneic mesenchymal stem cells have been safely administered to individuals with hemato-oncological diseases and in a limited number of patients with multiple sclerosis. It is therefore reasonable to move mesenchymal stem cells transplantation into properly controlled human studies to explore their potential as a treatment for multiple sclerosis. Since it is likely that the first such studies will probably involve only small numbers of patients in a few centers, we formed an international panel comprising multiple sclerosis neurology and stem cell experts, as well as immunologists. The aims were to derive a consensus on the utilization of mesenchymal stem cells for the treatment of multiple sclerosis, along with protocols for the culture of the cells and the treatment of patients. This article reviews the consensus derived from our group on the rationale for mesenchymal stem cell transplantation, the methodology for generating mesenchymal stem cells and the first treatment protocol for multiple sclerosis patients.
Peculiar temperature dependence of electric-field effect on magnetic anisotropy in Co/Pd/MgO system (2016)

We report on the temperature dependence of the magnetic anisotropy in Co/Pd/MgO system, in which magnetic moment in Pd is induced by the magnetic proximity effect. We demonstrate that the magnetic anisotropy is modulated by applying an electric field to the Pd surface. At temperatures below 100 K, we find the nonlinear electric-field dependence of the anisotropy with the sign reversal. We obtain a huge anisotropy modulation efficiency of ∼1600 fJ/V m at 10 K.
Membrane lectins enhance SARS-CoV-2 infection and influence the neutralizing activity of different classes of antibodies (2021)

Abstract Investigating the mechanisms of SARS-CoV-2 cellular infection is key to better understand COVID-19 immunity and pathogenesis. Infection, which involves both cell attachment and membrane fusion, relies on the ACE2 receptor that is paradoxically found at low levels in the respiratory tract, suggesting that additional mechanisms facilitating infection may exist. Here we show that C-type lectin receptors, DC-SIGN, L-SIGN and the sialic acid-binding Ig-like lectin 1 (SIGLEC1) function as auxiliary receptors by enhancing ACE2-mediated infection and modulating the neutralizing activity of different classes of spike-specific antibodies. Antibodies to the N-terminal domain (NTD) or to the conserved proteoglycan site at the base of the Receptor Binding Domain (RBD), while poorly neutralizing infection of ACE2 over-expressing cells, effectively block lectin-facilitated infection. Conversely, antibodies to the Receptor Binding Motif (RBM), while potently neutralizing infection of ACE2 over-expressing cells, poorly neutralize infection of cells expressing DC-SIGN or L-SIGN and trigger fusogenic rearrangement of the spike promoting cell-to-cell fusion. Collectively, these findings identify a lectin-dependent pathway that enhances ACE2-dependent infection by SARS-CoV-2 and reveal distinct mechanisms of neutralization by different classes of spike-specific antibodies.
EXPRESSION OF PROSTATE SPECIFIC MOLECULES IN BCG-POTENTIAL FOR IMMUNOTHERAPY (1999)

Zeoli, C.; Werber, J.; Peretz, G.; Bizgia, J.; Maitland, M.; Bloom, B.; Rose, H.; Mittelman, A.; Geliebter, J. Author Information
JVOX (1993)

article JVOX Share on Authors: David G. Smith View Profile , Joey K. Tuttle View Profile Authors Info & Claims ACM SIGAPL APL Quote QuadVolume 24Issue 1Aug. 1993 pp 251–258https://doi.org/10.1145/166198.166229Online:01 September 1993Publication History 0citation430DownloadsMetricsTotal Citations0Total Downloads430Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
FORMATION OF VOLATILE FLAVOR COMPOUNDS IN GREEN BEANS FROM LINOLEIC AND LINOLENIC ACIDS (1978)

ABSTRACT Both green beans and seeds formed n ‐hexanol, n ‐hexanal and 1‐octen‐3‐ol as the principal volatile compounds from U‐ 1 4 C‐labeled linoleic acid but at proportionately different ratios. With U‐ 1 4 C‐labeled linolenic acid, green beans developed mainly trans ‐2‐hexanal, 1‐penten‐3‐ol, 3‐penten‐1‐ol, trans ‐2‐hexenol and cis ‐3‐hexenol, while seeds produced largely 1‐penten‐3‐ol and 3‐penten‐3‐ol with a small amount of trans ‐2‐hexenal. Green beans showed the highest lipoxygenase activity of the several fruits and vegetables compared. Though alcohol oxidoreductase was relatively low, rapid reduction of aldehydes/ketones to alcohols was found in green beans. Green bean lipoxygenase was inhibited by cyanide and a small fraction appeared to be quite heat stable, compared to alcohol oxidoreductase which was much more unstable. The optimal activity of green bean lipoxygenase was found to be at pH 5.8.
Monitoring of circulating angiogenic factors in dendritic cell–based cancer immunotherapy (2003)

To our knowledge, the current report was the first to analyze circulating levels of angiogenic factors during dendritic cell-based immunotherapy. The authors observed a noteworthy change in the angiogenic blood profile with treatment, and this change was correlated with the induction of an immunologic response.
A New and Fast-Readout Interface for Resistive Chemical Sensors (2010)

The main issue concerning metal oxide (MOX) gas sensors is mostly related to the wide range of resistive values that the sensors can show. In addition, some sensors could have baseline resistive values up to tens of gigohms. To avoid the use of expensive picoammeters or the use of circuits adopting scaling factors, different solutions have recently been proposed, exploiting the resistance-to-time conversion (RTC) technique. They show good linearity and are suitable for the integration in a chip together with the elaboration unit, but they may require long measurement time (tens of seconds) if high resistance values need to be estimated. In addition, they may suffer the influence of a sensor parasitic capacitance, in parallel with the resistive component. In this paper, a new method is proposed to reduce the measuring time, keeping the advantages offered by the RTC approach and including a parasitic capacitance estimation feature. Particularly, an effective architecture, based on moving thresholds, has been proposed, simulated, and experimentally tested with commercial resistors (values between 1 M¿ and 100 G¿) and capacitors (values between 1 and 47 pF). Finally, a fast sensor transient, due to a rapid change in the heating power, has been acquired with the proposed instrument and compared with a similar transient analyzed with a classical RTC approach. This test has shown the applicability of the interface for solutions requiring detailed information of the sensor response, such as the characterization of new sensors (e.g., nanowires) or the behavior analysis during nonstandard thermal profiles.
The Use of Adenylate Kinase Measurement to Determine Causes of Lysis in Lager Yeast (2003)

The measurement of adenylate kinase activity in the supernatants of yeast suspensions was used as an indicator of yeast lysis. Activity was measured in the supernatants of aerobically propagated yeast suspensions, grown in wort or malt extract–yeast extract–glucose–peptone (MYGP) broth with and without various supplements. It was determined that the number of adenylate kinase units released by three production lager strains were similar under similar conditions, although variants of one strain displayed significant differences. Osmotic stress proved to have no effect on the number of adenylate kinase units released, whereas a substantial increase was observed when yeast was grown in the presence of ethanol. Ethanol addition to stationary-phase yeast resulted in small increases in the number of adenylate kinase units released.
A Comprehensive Study on Metal Triflate-Promoted Hydrogenolysis of Lactones to Carboxylic Acids: From Synthetic and Mechanistic Perspectives (2017)

Direct hydrogenolysis of lactone to carboxylic acid (i.e., hydrogenolysis of the Calkoxy–O bond with the carbonyl group untouched) is generally difficult, as the current strategies employing Brønsted acids as the catalyst usually require harsh conditions such as a high temperature and a high H2 pressure. Herein, we report a developed solvent-free catalytic transformation, in which W(OTf)6 is believed to promote the hydrogenolysis process. This strategy could efficiently hydrogenate lactones to carboxylic acids under extra mild conditions (e.g., a reaction temperature of <150 °C and 1 atm of H2) and showed a broad substrate scope. In addition, the catalytic protocol can be further applied to the hydrogenolysis of polyhydroxyalkanoate, as a renewable polymer, to the corresponding straight-chain carboxylic acids. An extensive mechanistic study was subsequently performed, and the density functional theory calculations revealed a reaction pattern, including the complete cleavage of the C═O bond with the assistance of the W(OTf)6 catalyst. Moreover, the key intermediate created in the mechanism, as an oxonium with an OTf moiety, was successfully detected by electrospray ionization mass spectra. Through a comparison with the Brønsted acid-catalyzed system, the study confirmed that the existence of the OTf moiety can significantly lower the barriers associated with the rearrangement and elimination processes. Meanwhile, emphasis was placed on the critical role that the anion plays, as well as the fact that the anion effect is directly related to the chemoselectivity.
The development and first clinical use of semipermeable microcapsules (artificial cells) as a compact artificial kidney. (1970)

Guest Editor's Introduction: Activated charcoal has a microporous structure and a large surface area that nonspecifically adsorbs the substances in the molecular weight range of 100–5,000, including hepatoxins, uremic toxins and drugs. The success of the first clinical trial for the treatment of chronic renal failure with an activated charcoal column was carried out by Yatidis in 1964, but the clinical application for the charcoal column has not been possible. This is because the charcoal presented major problems such as the release of microparticles and platelet activation. Chang solved these problems by developing the activated charcoal which was microcapsulated by biocompatible materials. Since then, many kinds of activated charcoal columns have been commercialized for blood purification use and are still widely utilized. This paper which describes the first clinical use of microcapsulated charcoal was printed in Trans Am Soc Artif Intern Organs, vol 16, page 141–148 (1970) and is reprinted here with permission.
Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2 (1997)

The oncogene bcl-2 encodes a 26-kD protein localized to intracellular membranes, including the ER, mitochondria, and perinuclear membrane, but its mechanism of action is unknown. We have been investigating the hypothesis that Bcl-2 regulates the movement of calcium ions (Ca2+) through the ER membrane. Earlier findings in this laboratory indicated that Bcl-2 reduces Ca2+ efflux from the ER lumen in WEHI7.2 lymphoma cells treated with the Ca2+-ATPase inhibitor thapsigargin (TG) but does not prevent capacitative entry of extracellular calcium. In this report, we show that sustained elevation of cytosolic Ca2+ due to capacitative entry is not required for induction of apoptosis by TG, suggesting that ER calcium pool depletion may trigger apoptosis. Bcl-2 overexpression maintains Ca2+ uptake in the ER of TG-treated cells and prevents a TG-imposed delay in intralumenal processing of the endogenous glycoprotein cathepsin D. Also, Bcl-2 overexpression preserves the ER Ca2+ pool in untreated cells when extracellular Ca2+ is low. However, low extracellular Ca2+ reduces the antiapoptotic action of Bcl-2, suggesting that cytosolic Ca2+ elevation due to capacitative entry may be required for optimal ER pool filling and apoptosis inhibition by Bcl-2. In summary, the findings suggest that Bcl-2 maintains Ca2+ homeostasis within the ER, thereby inhibiting apoptosis induction by TG.
Regioselective Mannich Condensation with Dimethyl(Methylene)Ammonium Trifluoroacetate: 1‐(Dimethylamino)‐4‐Methyl‐3‐Pentanone (2003)

Abstract Regioselective mannich condensation with dimethyl(methylene)ammonium trifluoroacetate: 1‐(dimethylamino)‐4‐methyl‐3‐pentanone intermediate: bis(dimethylamino)methane product: 1‐(dimethylamino)‐4‐methyl‐3‐pentanone
Looking back to electric cars (2012)

Very early experimental electric cars appeared just after electromagnetism was discovered, in 1820. During the nineteenth century they underwent improvements, staying in advance of internal combustion engines. A breakthrough came with the inventions of the rechargeable battery and of powerful and efficient electric motors, around 1870. Electrics peaked around the turn of the century, when they hold 38% of the automobile market in the US, compared with 40% of steam and 22% internal combustion. Their decline started in the second decade of the twentieth century when the internal combustion engine had a major boost, thanks to important advancements in the infrastructure, product and production technologies.
The Alzheimer Precision Medicine Initiative (2019)

Precision medicine (PM) is an evolving scientific renaissance movement implementing key breakthrough technological and scientific advances to overcome the limitations of traditional symptom- and sign-based phenotypic diagnoses and clinical "one-size-fits-all, magic bullet drug development" in these largely heterogeneous target populations. It is a conceptual shift from ineffective treatments for biologically heterogeneous "population averages" to individually-tailored biomarker-guided targeted therapies. PM is defining which therapeutic approach will be the most effective for a specific individual, at a determined disease stage, across multiple medical research fields, including neuroscience, neurology and psychiatry. The launch of the Alzheimer Precision Medicine Initiative (APMI) and its associated cohort program in 2016-facilitated by the academic core coordinating center run by the Sorbonne University Clinical Research Group in Alzheimer Precision Medicine (Sorbonne University GRC n°21 APM)"-is geared at transforming healthcare, conventional clinical diagnostics, and drug development research in Alzheimer's disease. Ever since the commencement of the APMI, the international interdisciplinary research network has introduced groundbreaking translational neuroscience programs on the basis of agnostic exploratory genomics, systems biology, and systems neurophysiology applying innovative "big data science", including breakthrough artificial intelligence-based algorithms. Here, we present the scientific breakthrough advances and the pillars of the theoretical and conceptual development leading to the APMI.
An automatic transmission model for vehicle control (2002)

This paper develops a dynamically-correct model of an automatic transmission, extending previous research results. The bond graph method is used in the modeling. The bond graph method is ideally suited for modeling "power" systems, because the method is based on generalized "power" variables. The bond graph method is capable of providing correct dynamic constraints and kinematic constraints, as well as the governing differential equations of motion. The bond graph method is used to develop 1-4 in-gear range models, as well as various upshift and downshift models, with proper dynamic and kinematic constraints.
Enhanced Transport into and out of Dead-End Pores (2015)

Dead-end micro- and nanoscale channels are ubiquitous in nature and are found in geological and biological systems subject to frequent disruptions. Achieving fluid flows in them is not possible through conventional pressure-driven mechanisms. Here we show that chemically driven convective flows leading to transport in and out of dead-end pores can occur by the phenomenon of "transient diffusioosmosis". The advective velocity depends on the presence of an in situ-generated transient ion gradient and the intrinsic charge on the pore wall. The flows can reach speeds of 50 μm/s and cause extraction of otherwise-trapped materials. Our results illustrate that chemical energy, in the form of a transient salt gradient, can be transduced into mechanical motion with the pore wall acting as the pump. As discussed, the phenomena may underlie observed transport in many geological and biological systems involving tight or dead-end micro- and nanochannels.
Estimation of the minimum laser linewidth achievable with a grazing-grating configuration (1983)

The influence of beam divergence on second-order grating dispersion terms is found and discussed. It is shown that divergence in the plane normal to the plane of incidence sets the lowest limit of the achievable linewidth. By using a double-grating configuration to achieve both spectral narrowing and tuning, one can obtain a laser line width down to approximately 0.01 A in a discharge-pumped XeF laser.
Decentralized Distribution of PCP Mappings Over Blockchain for End-to-End Secure Direct Communications (2019)

Network Address Translation (NAT) is a method that enables devices with private IP addresses to connect to the Internet by sharing a public IP address. Traversing the NAT device remains a challenge for a wide range of applications such as Voice over IP (VoIP) and Internet of Things (IoT). The Port Control Protocol (PCP) is a relatively new protocol standardized by the Internet Engineering Task Force (IETF) to solve the NAT traversal issues. It allows a NATed device to request and manage a mapping between its private IP address and transport-layer port to a public IP address and port. As PCP requires an application-dependent method for distributing the mappings to remote hosts, several attacks can target the distributing server and render the communication channel vulnerable. In this paper, we propose and implement a decentralized Blockchain-based approach for distributing PCP-mappings, enabling secure end-to-end (e2e) direct communications without any trusted third party server. NATed devices register their PCP mappings and public keys into the Blockchain, and other peers can then learn about these mappings to establish end-to-end secure direct communications. The implementation verifies that the system is feasible in terms of transactions fees, can simplify and secure end-to-end direct communications, and can interwork with conventional security methods.
Flexibility in Algal Endosymbioses Shapes Growth in Reef Corals (2004)

The relation between corals and their algal endosymbionts has been a key to the success of scleractinian (stony) corals as modern reef-builders, but little is known about early stages in the establishment of the symbiosis. Here, we show that initial uptake of zooxanthellae by juvenile corals during natural infection is nonspecific (a potentially adaptive trait); the association is flexible and characterized by a change in (dominant) zooxanthella strains over time; and growth rates of experimentally infected coral holobionts are partly contingent on the zooxanthella strain harbored, with clade C–infected juveniles growing two to three times as fast as those infected with clade D.