gebhart/patrepeval huggingface dataset:
Antibodies to a trypsin sensitive pancreatic antigen in chronic inflammatory bowel disease: specific markers for a subgroup of patients with Crohn's disease. (1991)

The presence of antibodies against pancreatic juice (PAB) in patients with Crohn's disease has recently been reported. In our study sera from 273 patients with inflammatory bowel disease (222 with Crohn's disease, 51 with ulcerative colitis) have been examined for PAB and also for antibodies against gut tissues by means of indirect immunofluorescence. PAB were found in 68 of the 222 patients with Crohn's disease (31%), with titres ranging from 1/10 to 1/1280, and in only two patients with ulcerative colitis (4%), with titres of 1/20. None were found in 198 patients with various chronic inflammatory diseases and healthy control subjects. No differences were found between the PAB positive and negative patients when the following parameters were compared: disease activity (Crohn's disease activity index), involvement of bowel segments, incidence of extraintestinal disease, or treatment with anti-inflammatory drugs. Only seven of the patients with Crohn's disease had a history of pancreatic disease and of these, four had detectable pancreatic antibodies. Longitudinal observations of 40 patients with Crohn's disease showed a stable pattern for PAB, independent of disease activity and treatment. Partial characterisation of the PAB antigen, isolated from pancreatic juice, showed a trypsin sensitive macromolecular protein of more than 10(6) daltons not identical with a panel of defined exocrine pancreatic proteins. By contrast, antibodies against goblet cells (GAB) were found in 13 of 51 patients with ulcerative colitis (29%) and in none of the patients with Crohn's disease or control subjects. PAB were found as a highly specific serological marker for Crohn's disease and GAB for ulcerative colitis, but the relevance of PAB and GAB in the pathogenesis in Crohn's disease remains unclear.
Advanced DSP Techniques Enabling High Spectral Efficiency and Flexible Transmissions: Toward elastic optical networks (2014)

In this article, we describe advances in digital signal processing (DSP) techniques that enable Tb/s transmission, and software-defined flexible transponders that support adaptive modulation formats and elastic optical networks (EONs).
DISCOGRAPHY: FALSE NEGATIVES AND THEIR INCIDENCE AND TREATMENT (2006)

Introduction Historically, lumbar discography has been one of the most controversial subjects in the management of discogenic low back pain. The diagnostic value of normal psychometric specific pain provocation by disc pressurization has emerged. The sensitivity, specificity and accuracy of discography as a diagnostic test are not in doubt. In clinical discography pain reproduction and location are essential elements. There is an accepted rate of 0–10% false positives. This rate is influenced by occupational disability and abnormal psychometric profiles. By contrast, little attention has been given to false negative results and their outcomes if surgically treated. Traditionally, whether or not the test is considered to be positive or negative is determined immediately after completion of the diagnostic procedure. This study shows that patient’s pain reproduction may occur up to 24 hours after the discogram which often initially interpreted as a true negative when it is actually a false negative result. This study verifies the existence and significance of a false negative through the patients’ treatment and outcomes. Methods In this study, 150 patients underwent discography for investigation of chronic persistent low back pain (CPLBP). All patients had a control (morphologically normal) discogram at the level above the degenerative segment. No patients with abnormal psychometric profiles or compensation were included. All patients were followed up 24 hours post discogram by the radiologist to further assess their clinical status. Ten of the patients (7.5%) were considered to have a false negative discogram, as per the Dallas Discogram Scale. The surgeon correlated the delayed response on the subsequent follow-up. These ten patients were diagnosed as having a positive response and were treated surgically for their discogenic pain. VAS-B, VAS-L, ODI, RMD were collected prospectively. Preoperative and 6 month results were reviewed. Results Seven of the 10 patients (70%) reported severe increase CPLBP and reproduction of pain within 8 hours of the discogram, while 3 patients (30%) did so in the ensuing 24 hours after the discogram. Surgical treatment was either by total disc replacement or anterior lumbar interbody fusion. All patients reported greater than 50% reduction in VAS-B and VAS-L and with improvements of greater than 50% in their ODI and RMD scores. Discussion The clinical reliability of discography hinges on the subjective assessment of pain concordance as the discriminating factor in determining false positives from false negatives. Given the limitations of discography, all information about the patient should be considered prior to diagnosis, including clinical, radiological, historical, and psychometric factors. The delayed positive discography response is an important consideration for the patient, the radiologist, and the treating surgeon to be aware of. The results of this study verify the existence of this subgroup and justify their surgical treatment.
Experimental Evidence for Large Ring Metallacycle Intermediates in Polyethylene Chain Growth Using Homogeneous Chromium Catalysts (2005)

Deuterio-ethylene labeling studies on two homogeneous chromium ethylene oligomerization catalysts show that chain propagation proceeds via metallacyclic intermediates; reactions performed in the presence of 1-nonene show no incorporation of the higher olefin, strongly implicating the involvement of large ring metallacycles.
Una pedagogía para la consolidación de la paz: práctica de un modelo integrador para el análisis y la respuesta a los conflictos (2015)

El presente articulo presenta un modelo de ensenanza original – una “pedagogia para la consolidacion de la paz” – disenado para ayudar a los estudiantes y profesionales a integrar el analisis de conflictos en sus intervenciones. El autor habla sobre la importancia del analisis de los conflictos y campara enfoques alternativos, centrandose en la teoria vs. el contexto vs. las prioridades tecnocraticas. El articulo explica entonces las “teorias del modelo de cambio integradas” del autor y entrelaza siete elementos: 1) el analisis del contexto y la evaluacion de las necesidades, 2) el objetivo general de la intervencion, 3) la teoria del cambio, 4) los objetivos y actividades especificas, 5) los beneficiarios, partes interesadas y saboteadores, 6) el alcance, recursos y riesgos, y 7) los indicadores de exito. En un mundo fragmentado asediado por distintos conflictos sociales, politicos y familiares necesitamos herramientas abarcadoras (y formacion practica) para entender mejor el conflicto y poder responder a el.
Refractory Childhood Epilepsy and Factors Related to Refractoriness (2000)

To clarify the characteristics of refractory childhood epilepsy, we compared recent refractory cases and those of approximately 15 years ago, all of which were seen at the Okayama University Hospital. We also analyzed predictive factors related to refractoriness in the recent refractory cases. Among the recent refractory cases, the proportion of localization-related epilepsies increased, and the proportion of generalized epilepsies decreased compared to historical cases. In generalized epilepsies, the proportion of cases with Lennox-Gastaut syndrome decreased to less than half. In localization-related epilepsies, the proportion of cases with frontal lobe epilepsy increased. The proportion of cases with unknown causes decreased to less than half. Of the cases with known causes, postencephalitis/postencephalopathy and focal cortical malformation, including tuberous sclerosis, accounted for most of the cases. More of the recent refractory cases were treated with high-dose AED monotherapy, compared to more polytherapy in the cases of 15 years earlier. The following factors were related to future refractoriness: less than 1 year of age at onset of seizures, the presence of underlying pathology, status epilepticus. changes in type of epilepsy during the clinical course, and neonatal seizures. Regarding EEG findings of cases that had localization-related epilepsies at the end of follow-up, focal spike-waves associated with diffuse spike-waves on the first EEGs indicated future refractoriness.
Abstract 5291: Non-coding satellite RNAs are highly expressed in cancer adjacent lesions of human pancreatic carcinoma and may promote oncogenesis . (2013)

Abstract It was believed that most satellite repeats in pericentric heterochromatin region were silenced and rarely transcribed into RNAs. However, a few reports suggest that non-coding satellite RNAs may play a significant role in cell division, heterochromatin remodeling or DNA damage such as other well-researched non-coding RNAs. In fact, a next generation digital gene expression method recently revealed that human satellite II (HSATII) transcripts are highly and specifically upregulated in human pancreatic tumors. To further explore these findings, we examined the precise localization of HSATII transcripts in human clinical pancreatic tissues by in situ hybridization using highly sensitive locked nucleic acid-modified oligonucleotide probes. Unexpectedly, HSATII RNAs were not detected in pancreatic ductal cancerous lesions, in almost all cases examined. Instead, HSATII RNAs were clearly expressed in non-cancerous adjacent acinar cells, surrounding carcinoma tissues. On the other hand, none of normal or inflammatory pancreatic tissues derived from the ones without cancer expressed HSATII RNAs. While, HSATII transcript expression in normal pancreatic ductal cells could not be induced in vitro even under stress conditions which mimic the tumor-adjacent environments, the cells with ectopic expression of HSATII transcripts showed the increase foci of gH2AX, which may reflect the increased genomic instability. These results suggest that the expression of HSATII may not be phenotypic changes in cancers but may directly contribute to the oncogenesis in the cells in precancerous lesions. Citation Format: Takahiro Kishikawa. Non-coding satellite RNAs are highly expressed in cancer adjacent lesions of human pancreatic carcinoma and may promote oncogenesis . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5291. doi:10.1158/1538-7445.AM2013-5291
THE SYNTHESIS OF LIGNIN MODEL SUBSTANCES: 5-HYDROXYVANILLIN AND 5-HYDROXYACETOGUAIACONE (1962)

not available
Elastohydrodynamic Lubrication in Biological Systems (2005)

Abstract Elastohydrodynamic lubrication (EHL) appears to be an important mechanism in various biological systems. In this paper, a few examples will be selected to illustrate the biological applications of EHL: microcirculation of red blood cells in capillaries, blinking of eye and contact lens, and respiratory motion between pleural surfaces and articulation in synovial joints. It is shown that the relatively large elastic deformation of the bearing surfaces associated with relatively compliant biological tissues is responsible for the major contribution of fluid film action to the lubrication at both tissue and cellular levels. Under unfavourable lubrication conditions, the articulating surfaces can be protected by the powerful effect of micro-EHL in smoothing out surface asperities and further by the glycocalyx present on the biological surfaces.
Isolation and characterization of a 60-kilodalton glycoprotein esterase from liver microsomal membranes. (1987)

A glycoprotein having a subunit weight of approximately 60,000 was isolated from rabbit liver microsomes. It is a predominant component of the hepatic microsomal membrane and reacts rapidly with diisopropylphosphorofluoridate (DFP), resulting in the loss of enzymatic activity toward artificial substrates such as acyl esters of o-nitrophenols. Automated Edman degradation of this protein together with sequence analysis of peptides provided the NH2-terminal sequence of some 70 residues as follows: His-Pro-Ser- Ala-Pro-Pro-Val-Val-Asp-Thr-Val-Lys-Gly-Lys-Val- Leu-Gly-Lys-Phe-Val-Ser-Leu-Glu-Gly-Phe-Ala-Gln- Pro-Val-Ala-Val-Phe-Leu-Gly-Val-Pro-Phe-Ala-Lys- Pro-Pro-Leu-Gly-Ser-Leu-Arg-Phe-Ala-Pro-Pro-Gln- Pro-Ala-Glu-Ser-Trp-Ser-His-Val-Lys-Asn (CHO)- Thr-Thr-Ser-Tyr-Pro-Pro-Met-Cys-Ser-Ser. A carbohydrate attachment was identified at asparaginyl residue 61. The COOH-terminal peptide of the protein was isolated from two independent enzymatic digests, and its sequence was established as Arg-Glu-Thr-Glu-His-Ile-Glu-Leu. In order to isolate the DFP binding peptide, liver microsomes were labeled with [3H]DFP and the 60-kDa protein containing covalently bound DFP isolated in pure form. Following reduction and carboxymethylation, the DFP-labeled protein was fragmented with trypsin and the digest subjected to gel filtration. Digestion of the labeled peptide preparations with chymotrypsin followed by chromatography of the digest yielded two diisopropylphosphoryl (DIP) peptides. Automated Edman degradation of these peptides provided the following amino acid sequences: Gly-Glu-DIPSer- Ala-Gly-Gly-Gln-Ser-Val-Ser-Ile-Leu-Leu-Leu-Ser- Pro and Thr-Val-Ile-Gly-Asp-DIPHis-Gly-Asp-Glu-Ile-Phe. The active site serine peptide of the 60-kDa protein shows some 70% similarity to the active center region of choline esterases. While the postulated active histidyl residue in choline esterases has not been identified, it is proposed that the DFP binding histidine of the 60-kDa protein corresponds to His-438/440 of choline esterases.
Effect of Alkyl Derivatization on Several Properties of <i>N</i>-Halamine Antimicrobial Siloxane Coatings (2008)

Variation of alkyl substitution at position 5 on the hydantoin ring of a series of N-halamine siloxane derivatives has been employed to better understand the biocidal activities of these compounds for use in preparing antimicrobial coatings. The alkyl derivatization of the hydantoin ring at its 5 position, while an essentially constant chlorine loading is maintained at the 1 position, has shown that there is little dependence of the antimicrobial efficacy against Escherichia coli O157:H7 on the alkyl chain length, in contrast to reported observations for biocidal quaternary ammonium salt derivatives. The stabilities of the derivatives toward hydrolyses and ultraviolet light exposure have also been found to not be dependent upon the nature of the alkyl substituent group. These observations led to the conclusion that the 5,5-dimethyl derivative would be recommended for use, since it is the least expensive alternative.
Prospective Randomized Multicenter Trial of Empirical Antitachycardia Pacing Versus Shocks for Spontaneous Rapid Ventricular Tachycardia in Patients With Implantable Cardioverter-Defibrillators (2004)

Compared with shocks, empirical ATP for FVT is highly effective, is equally safe, and improves quality of life. ATP may be the preferred FVT therapy in most ICD patients.
Use of near-isogenic wheat lines to determine glutenin and gliadin composition and funtionality in flour tortillas (2006)

The synthesis of high molecular weight (HMW) glutenin, low molecular weight glutenin and gliadin proteins are controlled by nine major loci present in wheat chromosomes. The loci Glu A1, Glu B1, Glu D1 and Gli A1, Gli B1, Gli D1 and Gli 2 and their allelic variants play important roles in determining the functional properties of wheat flour. This study focused on understanding the functionality of these protein subunits with respect to tortilla quality for use in developing varieties with ideal tortilla baking quality. Near-isogenic wheat lines in which one or more of these loci were absent or deleted were used in the study. These lines were analyzed using SSR primers to verify the chromosome deletions. A standard SDS PAGE gel and a Lab on Chip Capillary Electrophoresis method were used to confirm the protein composition of the deletion lines. Tortillas were prepared from each deletion line and the parent lines used to derive the deletion lines, and tortilla quality evaluations were analyzed. The analysis has revealed that elimination of certain HMW glutenins results in gain of function both for tortilla diameters and overall tortilla quality. The deletion line possessing 17+18 at Glu B1 and deletions in Glu A1 and Glu D1 had a gain of function in tortilla diameter, yet tortilla stability was compromised. The deletion line possessing Glu A1, Glu D1 (1,5+10) and a deletion in Glu B1 improved both the diameters and stability of the tortillas. Presence of subunits 5+10 is important for maintaining tortilla stability. Deletions in gliadin monomeric proteins also affected the tortilla diameters and stability.
Qualitative vision-based mobile robot navigation (2006)

We present a novel, simple algorithm for mobile robot navigation. Using a teach-replay approach, the robot is manually led along a desired path in a teaching phase, then the robot autonomously follows that path in a replay phase. The technique requires a single off-the-shelf, forward-looking camera with no calibration (including no calibration for lens distortion). Feature points are automatically detected and tracked throughout the image sequence, and the feature coordinates in the replay phase are compared with those computed previously in the teaching phase to determine the turning commands for the robot. The algorithm is entirely qualitative in nature, requiring no map of the environment, no image Jacobian, no homography, no fundamental matrix, and no assumption about a flat ground plane. Experimental results demonstrate the capability of autonomous navigation in both indoor and outdoor environments, on both flat and slanted surfaces, with dynamic occluding objects, for distances over 100 m
Changes in axon birefringence during the action potential (1970)

1. Observations have been made on the changes in optical retardation accompanying the passage of impulses along crab leg nerves and squid giant axons.2. The nerves were mounted on the stage of a polarizing microscope, at 45 degrees to the planes of polarization and analysis, brightly illuminated with white light. During the nerve impulse the intensity of the light passing the analyser decreased temporarily by 1 part in 10(3)-10(6). Signal-averaging techniques were used to obtain an acceptable ratio of signal to noise.3. The changes in light intensity recorded under these conditions were shown to arise almost entirely from alterations in retardation, with little or no interference from scattering, absorption, linear dichroism or optical rotation effects; the occurrence of stimulus and coupling artifacts was also ruled out.4. In the squid giant axon, the retardation change was shown to be located in a thin cylinder immediately surrounding the axoplasm, and to have a radially oriented optic axis.5. The time course of the decrease in optical retardation was very similar to that of the action potential recorded with an intracellular electrode, suggesting that the retardation closely followed the electrical potential across the membrane.
Isolation and characterization of the 1,4-<i>β</i>-<scp>d</scp>-glucan glucanohydrolases of <i>Talaromyces emersonii</i> (1985)

Culture filtrates of Talaromyces emersonii were found to contain four endocellulases termed I, II, III and IV, the last having the greatest electrophoretic mobility towards the anode in homogeneous 5%-(w/v)-polyacrylamide gels at pH 4.5. All four are glycoproteins, the carbohydrate contents being: I, 27.7%; II, 29.0%; III, 44.7%; IV, 50.8. Each form is eluted as a single peak corresponding to an Mr value of 68000 on gel filtration at pH 3.5 and as a single band corresponding to an Mr value of 35000 on reductive sodium dodecyl sulphate/polyacrylamide-gradient-gel electrophoresis. However, we believe that the latter represents the native Mr value. The pI values for each lie between pH 2.8 and 3.2. Activity in each case is optimal at pH 5.5-5.8 and at 75-80 degrees C. Half-life values at pH5 and 75 degrees C were from 2 to 4h. The specific activity with any individual substrate was much the same for each enzyme, as was the ratio of activity from one substrate to the next. Possible reasons for the observation that plots of velocity versus substrate concentration are sigmoidal are discussed. We believe that the finding of four endocellulases reflects differential glycosylation of a single enzyme form rather than genetically determined differences in primary structure.
Determining Confidence Intervals When Measuring Genetic Diversity and the Discriminatory Abilities of Typing Methods for Microorganisms (2001)

We describe here a method for determining confidence intervals for a commonly used index of diversity. This approach facilitates the comparison of the genetic population structure of microorganisms isolated from different environments and improves the objective assessment of the discriminatory power of typing techniques.
FlexSaaS (2019)

Web search engines deploy large-scale selection services on CPUs to identify a set of web pages that match user queries. An FPGA-based accelerator can exploit various levels of parallelism and provide a lower latency, higher throughput, more energy-efficient solution than commodity CPUs. However, maintaining such a customized accelerator in a commercial search engine is challenging because selection services are changed often. This article presents our design for FlexSaaS (Flexible Selection as a Service), an FPGA-based accelerator for web search selection. To address efficiency and flexibility challenges, FlexSaaS abstracts computing models and separates memory access from computation. Specifically, FlexSaaS (i) contains a reconfigurable number of matching processors that can handle various possible query plans, (ii) decouples index stream reading from matching computation to fetch and decode index files, and (iii) includes a universal memory accessor that hides the complex memory hierarchy and reduces host data access latency. Evaluated on FPGAs in the selection service of a commercial web search--the Bing web search engine—FlexSaaS can be evolved quickly to adapt to new updates. Compared to the software baseline, FlexSaaS on Arria 10 reduces average latency by 30% and increases throughput by 1.5×.
Functional cardiac MR imaging with steady‐state free precession (SSFP) significantly improves endocardial border delineation without contrast agents (2001)

Contrast between blood and myocardium in standard turbo gradient echo MR techniques (TFE) used routinely in clinical practice is mainly caused by unsaturated inflowing blood. Steady-state free precession (SSFP) has excellent contrast even in the absence of inflow effects. In 45 subjects cardiac cine loops in two long axis projections were acquired using TFE and compared with SSFP. A visual score (range 0 worst - 3 best) was assigned for endocardial border delineation for six myocardial segments in two long axis views. Endocardial border delineation score for TFE was 1.3 +/- 0.3 per segment and 2.4 +/- 0.3 for SSFP (P < 0.0001). Signal intensity blood/signal intensity myocardium was 1.5 +/- 0.4 at enddiastole and 1.4 +/- 0.3 at systole for TFE and 3.5 +/- 1.1 and 3.2 +/- 1.3 for SSFP, respectively (P < 0.0001). SSFP increases contrast between blood and myocardium more than twofold, resulting in an improved endocardial border definition. This may reduce variability for the determination of cardiac volumes and ejection fraction.