gebhart/patrepeval huggingface dataset:
Are breast cancers driven by fusion genes? (2012)

For many years, it was assumed that gene fusions were a type of mutation confined largely to leukemias and sarcomas. However, fusion genes are now known to be important in several epithelial cancers and a number have been described in breast cancers. In the December 2011 issue of Nature Medicine, Robinson and colleagues reported many more gene fusions -including the first recurrent fusion, SEC16A-NOTCH1 - in breast cancers. Several genes, including members of the MAST (microtubule-associated serine threonine) kinase and Notch gene families, are fused more than once. This finding supports an emerging story that most breast cancers express a number of fusion genes.
Proposed embedded security framework for Internet of Things (IoT) (2011)

IoT is going to be an established part of life by extending the communication and networking anytime, anywhere. Security requirements for IoT will certainly underline the importance of properly formulated, implemented, and enforced security policies throughout their life-cycle. This paper gives a detailed survey and analysis of embedded security, especially in the area of IoT. Together with the conventional security solutions, the paper highlights the need to provide in-built security in the device itself to provide a flexible infrastructure for dynamic prevention, detection, diagnosis, isolation, and countermeasures against successful breaches. Based on this survey and analysis, the paper defines the security needs taking into account computational time, energy consumption and memory requirements of the devices. Finally, this paper proposes an embedded security framework as a feature of software/hardware co-design methodology.
Los nombres de Deméter (1996)

Reflexión sobre los nombres que le atribuyen a la diosa griega Deméter diversos autores, como Homero o Hesíodo, y que se encuentran directamente en relación con sus características, actos y campos de acción, como son la agricultura y la fertilidad del campo, entre otros.
MirrorTrack &#x2014; a real-time multiple camera approach for multi-touch interactions on glossy display surfaces (2008)

This paper presents a real-time multiple camera approach for multi-touch interaction system that takes advantage of specular display surface (such as conventional LCD displays) and the mirror-effect in a low-azimuth camera angle to detect and track fingers their reflections simultaneously. Building on our prior work, 1. We use multi-resolution processing to greatly improve runtime performance of the system; 2. We employ different edge detection and pattern recognition algorithms for different processing resolution to help detect fingers more accurately and efficiently; 3. We track both the location of a fingertip and its pointing direction so it can be identified more effectively; 4. We use a full stereo algorithm to compute finger locations in the 3D space more accurately. Our system has many advantages. 1. It works with any glossy flat panel display; 2. It avoids clumsy set-up time of a top-down camera with the concomitant screen glare problems; 3. It supports both touch and hover operation; 4. It can work with large vertical display without the usual occlusion problems. We describe our approach and implementation in details.
Ultrasonography to assess and enhance health and reproduction in the giant panda (2006)

Ultrasonography is a routine diagnostic procedure used for assessing soft tissue characteristics in the human and veterinary medical fields of ophthalmology, cardiology, neurology, nephrology, obstetrics, oncology and orthopaedics. Because various forms of ultrasonography have existed for more than 50 years, it is surprising that this technology has only recently been applied to the study and management of wildlife species (Hildebrandt & Göritz, 1998; Hildebrandt et al., 2003). Nonetheless, there already is enough evidence making it clear that ultrasonography, combined with other technologies, can address issues that directly impact the health and reproductive welfare of wildlife species. This chapter focuses on the relevance of this technique for assisting in the assessment of medical and reproductive health in the giant panda.
A resolution and frame-rate scalable subband/wavelet video coder (2001)

A source coding algorithm is presented which delivers a spatiotemporal scalable encoded bitstream. Motion compensated temporal filtering is combined with a spatial subband/wavelet pyramid to provide an efficient 3-D multiresolution representation. Error-feedback hierarchical coding permits near-optimal results for each subvideo. The proposed ordering of refinement addresses the noncommutative property of motion compensated temporal filtering and spatial subband/wavelet analysis. Finally, adaptive conditional arithmetic coding of quantizer significance maps increases coding efficiency. Experimental results demonstrate a significant improvement in performance over earlier published algorithms. The code-and-refine nature of our hierarchical algorithm makes it possible to use the algorithm as a scalable extension to other source coding algorithms. Finally, the complexity of the algorithm is modest and is well suited to parallel implementation.
1.6 Tbit/s (40×42.7 Gbit/s) WDM transmission over 2400 km of fibre with 100 km dispersion-managed spans (2002)

Transmission of 40×42.7 Gbit/s WDM channels is demonstrated over 2400 km of fibre with 100 km amplifier spacing and 100 GHz channel spacing. Dispersion-managed fibre spans, carrier-suppressed return-to-zero modulation format and hybrid Raman/erbium-doped fibre inline amplifiers were employed to achieve a record 40 Gbit/s, WDM transmission distance with 100 km terrestrial span lengths.
An Automatic Online Recruitment System Based on Exploiting Multiple Semantic Resources and Concept-Relatedness Measures (2015)

Due to the rapid development of job markets, traditional recruitment methods are becoming insufficient. This is because employers often receive an enormous number of applications (usually unstructured resumes) that are difficult to process and analyze manually. To address this issue, several automatic recruitment systems have been proposed. Although these systems have proved to be more effective in processing candidate resumes and matching them to their relevant job posts, they still suffer from low precision due to limitations of their underlying techniques. On the one hand, approaches based on keyword matching ignore the semantics of the job post and resume contents, and consequently a large portion of the matching results is irrelevant. On the other hand, the more recent semantics-based models are influenced by the limitations of the used semantic resources, namely the incompleteness of the knowledge captured by such resources and their limited domain coverage. In this paper, we propose an automatic online recruitment system that employs multiple semantic resources to highlight the semantic contents of resumes and job posts. Additionally, it utilizes statistical concept-relatedness measures to further enrich the highlighted contents with relevant concepts that were not initially recognized by the used semantic resources. The proposed system has been instantiated and validated in a precision-recall based empirical framework.
Study of the Capacity Fading Mechanism for Fe-Substituted LiCoO[sub 2] Positive Electrode (2004)

To find the origin of a large initial irreversible capacity and capacity fading with cycling for Fe-substituted the positive electrode was selected for study by ex situ X-ray diffraction, Co and Fe K-edge X-ray absorption, and Mössbauer spectroscopies. A disordering of Fe ions from 3b(0, 0, 1/2) to 6c(0, 0, 3/8) sites was detected for initial charged samples through X-ray Rietveld analysis and Co and Fe K-edge X-ray absorption near-edge structures and extended X-ray fine structures spectra. The valence state of Fe ions in the 6c site was determined to be a 3+/4+ mixed valence state from the isomer shift values obtained by Mössbauer spectra and mean M-O distance values. 50% of the iron ions become disordered after the initial charge process and more than 20% remain in 6c sites after the first and tenth discharge processes. The existence of ions on the interstitial 6c site can block fast Li conduction in the Li layer of the layered rock-salt structure This leads to a lack of reversibility in Fe-substituted positive electrode materials. © 2004 The Electrochemical Society. All rights reserved.
QM/MM modeling the Ras–GAP catalyzed hydrolysis of guanosine triphosphate (2005)

The mechanism of the hydrolysis reaction of guanosine triphosphate (GTP) by the protein complex Ras-GAP (p21(ras) - p120(GAP)) has been modeled by the quantum mechanical-molecular mechanical (QM/MM) and ab initio quantum calculations. Initial geometry configurations have been prompted by atomic coordinates of a structural analog (PDBID:1WQ1). It is shown that the minimum energy reaction path is consistent with an assumption of two-step chemical transformations. At the first stage, a unified motion of Arg789 of GAP, Gln61, Thr35 of Ras, and the lytic water molecule results in a substantial spatial separation of the gamma-phosphate group of GTP from the rest of the molecule (GDP). This phase of hydrolysis process proceeds through the low-barrier transition state TS1. At the second stage, Gln61 abstracts and releases protons within the subsystem including Gln61, the lytic water molecule and the gamma-phosphate group of GTP through the corresponding transition state TS2. Direct quantum calculations show that, in this particular environment, the reaction GTP + H(2)O --> GDP + H(2)PO(4) (-) can proceed with reasonable activation barriers of less than 15 kcal/mol at every stage. This conclusion leads to a better understanding of the anticatalytic effect of cancer-causing mutations of Ras, which has been debated in recent years.
Synthesis and Ring-Opening Reactions of the Diastereoisomericcis- andtrans-Epoxides Derived from 3-(Benzyloxy)cyclopentene and 2-(Benzyloxy)-2,5-dihydrofuran (1998)

The regiochemical outcome of the ring-opening of epoxides bearing remote polar functionalities has been established in the case of carbocyclic (1 and 2) and the corresponding furanosidic (3 and 4) title epoxides. Under standard conditions, the regioisomeric C-1 products are the sole (from trans epoxides 2 and 4) or predominant (from cis epoxides 1 and 3) ring-opening products. However, under chelating conditions, and only in the case of the cis epoxides 1 and 3, a consistent increase in C-2 selectivity is unexpectedly observed.
ChemInform Abstract: 129Xe NMR of Silver‐Exchanged X‐ and Y‐Type Zeolites. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling of Pressure Buildup on a Kicking Well and Its Practical Application (1996)

Abstract This paper describes a new method for prediction of pore pressure and formation permeability from a kicking well. Getting reliable and accurate information about reservoir parameters (when the formation damage is minimal) is of critical importance for making proper well completion decisions. In addition, when a well kicks, inaccurate estimation of the formation pressure may cause loss of equipment and possibly the well and human lives. To combat the above problems, a conventional pressure analysis method is modified to predict the formation pore pressure and estimate directional formation permeabilities from a kicking well. The method is simple, and the only prerequisite is that the buildup data be collected upon shutting-in a kicking well. Examples of using simulated as well as actual field data, are provided to demonstrate the practical application of the method.
Systems-level analysis of mechanisms regulating yeast metabolic flux (2016)

Cellular metabolic fluxes are determined by enzyme activities and metabolite abundances. Biochemical approaches reveal the impact of specific substrates or regulators on enzyme kinetics but do not capture the extent to which metabolite and enzyme concentrations vary across physiological states and, therefore, how cellular reactions are regulated. We measured enzyme and metabolite concentrations and metabolic fluxes across 25 steady-state yeast cultures. We then assessed the extent to which flux can be explained by a Michaelis-Menten relationship between enzyme, substrate, product, and potential regulator concentrations. This revealed three previously unrecognized instances of cross-pathway regulation, which we biochemically verified. One of these involved inhibition of pyruvate kinase by citrate, which accumulated and thereby curtailed glycolytic outflow in nitrogen-limited yeast. Overall, substrate concentrations were the strongest driver of the net rates of cellular metabolic reactions, with metabolite concentrations collectively having more than double the physiological impact of enzymes.
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition (2011)

Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation of BRCA2 and inhibits HR. We demonstrate that hyperthermia can be used to sensitize innately HR-proficient tumor cells to PARP-1 inhibitors and that this effect can be enhanced by heat shock protein inhibition. Our results, obtained from cell lines and in vivo tumor models, enable the design of unique therapeutic strategies involving localized on-demand induction of HR deficiency, an approach that we term induced synthetic lethality.
Exactions as Takings Tactics for Dealing with<i>Dolan</i> (1994)

Abstract In Dolan v. City of Tigard, No. 93-518, (1994), 46 ZD 232/ the United States Supreme Court announced a sweeping new federal takings standard that is receiving much attention from attorneys and planners across America. In Dolan, the Court ruled that a condition requiring the landowner to dedicate the floodplain and an adjacent IS-foot strip of land for flood control and a pedestrian/bicycle pathway consti-tuted a regulatory taking without payment of just compen-sation. In reversing the decision of the Oregon Supreme Courtupholdingthe city's conditions, the Courtcreated new land-use takings lawthatpromises to significantly alter local government practices in imposing traditional development exactions and in attaching conditions to development ap-provals. This article describes the Court's decision, the new takings test for development exactions, the general and spe-cific impacts of the new takings law/ and municipal strate-gies for dealing with them.
Evaluation of an Expanded Microarray for Detecting Antibiotic Resistance Genes in a Broad Range of Gram-Negative Bacterial Pathogens (2012)

A microarray capable of detecting genes for resistance to 75 clinically relevant antibiotics encompassing 19 different antimicrobial classes was tested on 132 Gram-negative bacteria. Microarray-positive results correlated >91% with antimicrobial resistance phenotypes, assessed using British Society for Antimicrobial Chemotherapy clinical breakpoints; the overall test specificity was >83%. Microarray-positive results without a corresponding resistance phenotype matched 94% with PCR results, indicating accurate detection of genes present in the respective bacteria by microarray when expression was low or absent and, hence, undetectable by susceptibility testing. The low sensitivity and negative predictive values of the microarray results for identifying resistance to some antimicrobial resistance classes are likely due to the limited number of resistance genes present on the current microarray for those antimicrobial agents or to mutation-based resistance mechanisms. With regular updates, this microarray can be used for clinical diagnostics to help accurate therapeutic options to be taken following infection with multiple-antibiotic-resistant Gram-negative bacteria and prevent treatment failure.
Cycle-IR: Deep Cyclic Image Retargeting (2019)

Supervised deep learning techniques have achieved great success in various fields due to getting rid of the limitation of handcrafted representations. However, most previous image retargeting algorithms still employ fixed design principles such as using gradient map or handcrafted features to compute saliency map, which inevitably restricts its generality. Deep learning techniques may help to address this issue, but the challenging problem is that we need to build a large-scale image retargeting dataset for the training of deep retargeting models. However, building such a dataset requires huge human efforts. In this paper, we propose a novel deep cyclic image retargeting approach, called Cycle-IR, to firstly implement image retargeting with a single deep model, without relying on any explicit user annotations. Our idea is built on the reverse mapping from the retargeted images to the given images. If the retargeted image has serious distortion or excessive loss of important visual information, the reverse mapping is unlikely to restore the input image well. We constrain this forward-reverse consistency by introducing a cyclic perception coherence loss. In addition, we propose a simple yet effective image retargeting network (IRNet) to implement the image retargeting process. Our IRNet contains a spatial and channel attention layer, which is able to discriminate visually important regions of input images effectively, especially in cluttered images. Given arbitrary sizes of input images and desired aspect ratios, our Cycle-IR can produce visually pleasing target images directly. Extensive experiments on the standard RetargetMe dataset show the superiority of our Cycle-IR.
Anticonvulsant and antitremor effects of chlorphenoxamine. (1961)

Two benzhydryl ether compounds, chlorphenoxamine and its diethyl analog, Keithon, were subjected to pharmacologic evaluation. By either the intraperitoneal or intragastric route, both compounds extended the normal sleeping time of hexobarbital in mice. Anticonvulsant testing revealed that both drugs protected mice in the MES test and prevented the tonic extensor component of the maximal pentylenetetrazol test. Neither drug prevented the convulsions in mice resulting from the subcutaneous administration of pentylenetetrazol nor did they prevent the lethal effects of strychnine. Both drugs prevented the centrally induced convulsions in mice resulting from intravenous nicotine. They were found also to be antagonists of Tremorine-induced tremors in mice and reversed the analgetic effects when this agent was injected intramuscularly in mice. In doses of 5 mg/kg intravenously, both chlorphenoxamine and Keithon either completely abolished or favorably altered the course of the jerking tic in clinical cases of the canine flexor spasm syndrome. The overall effect in this condition was the alteration of the tremor from a slow, coarse, disabling jerk to a faster but much less severe tremor.
Which Is Plagiarism: Fashion Image Retrieval Based on Regional Representation for Design Protection (2020)

With the rapid growth of e-commerce and the popularity of online shopping, fashion retrieval has received considerable attention in the computer vision community. Different from the existing works that mainly focus on identical or similar fashion item retrieval, in this paper, we aim to study the plagiarized clothes retrieval which is somewhat ignored in the academic community while itself has great application value. One of the key challenges is that plagiarized clothes are usually modified in a certain region on the original design to escape the supervision by traditional retrieval methods. To relieve it, we propose a novel network named Plagiarized-Search-Net (PS-Net) based on regional representation, where we utilize the landmarks to guide the learning of regional representations and compare fashion items region by region. Besides, we propose a new dataset named Plagiarized Fashion for plagiarized clothes retrieval, which provides a meaningful complement to the existing fashion retrieval field. Experiments on Plagiarized Fashion dataset verify that our approach is superior to other instance-level counterparts for plagiarized clothes retrieval, showing a promising result for original design protection. Moreover, our PS-Net can also be adapted to traditional fashion retrieval and landmark estimation tasks and achieves the state-of-the-art performance on the DeepFashion and DeepFashion2 datasets.
Effect of substance P released from peripheral nerve ending on endogenous expression of epidermal growth factor and its receptor in wound healing. (2002)

During wound healing, SP may promote the healing process by affecting the expression of EGF/EGFR in the granulation tissues.
Spatially superposed M-ary QAM wireless communication system (2006)

We present a spatially superposed Mary-quadrature amplitude modulation (QAM) communication system that can provide efficient use of frequency resources and transmitted power. The system incorporates multiple conventional quaternary phase shift key (QPSK) modulators and combines their output signals spatially with a specially tailored antenna array to produce an M-ary QAM signal. Thus, it can operate on power amplifiers driven in the high efficiency region and relax the strict requirements for the hardware as compared to conventional M-ary QAM systems. The proposed system, however, is sensitive to superposition error. A novel antenna array system is presented that can minimize the superposition error.
Pulse-time-modulated electron cyclotron resonance plasma etching with low radio-frequency substrate bias (1996)

The etching characteristics of polycrystalline silicon (poly-Si) by short-time modulated electron cyclotron resonance (ECR) determined by using a Cl2 etchant were investigated. It was found that the poly-Si etching rate was improved by increasing the pulse interval of the microwaves to more than 50 μs for a 50% duty ratio and applying a 600 kHz rf bias to the substrate. A large amount of negative chlorine ions are generated in the afterglow which occurs for more than 50 μs in high-density, low-pressure plasmas. The low rf bias alternately accelerates both the negative and positive ions to the substrate surface. As a result, the pulse-time modulated ECR plasma can produce high rate and charge-free etching with a 600 kHz rf bias.
Exploitation of periodicity in logic simulation of synchronous circuits (2002)

An overwhelming majority of logic designers use synchronous logic design techniques to manage the complexity of their designs and rely on logic simulation techniques for design verification. Yet, logic simulators do not take advantage of the higher abstraction level provided by synchronous logic design techniques to improve their performance. A general technique is presented which takes advantage of the high degree of periodicity common in synchronous logic designs. It is shown that a performance improvement of at least 200% occurs when these techniques are applied within the COSMOS. simulation system to simulate large digital systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>