gebhart/patrepeval huggingface dataset:
The role of public sector asset managers in responding to climate change (2010)

Purpose The purpose of this paper is to describe the current climate change predictions and the likely consequences for building assets, and therefore the delivery of public services, in the face of extreme weather events. Public sector asset managers need to mitigate and prepare for future events. However, current practice, as illustrated by the literature, shows that little risk assessment is currently undertaken. Design/methodology/approach This paper is based on a literature review of current climate data and best practice asset management. An extensive survey of public sector asset managers working at senior levels in their organisation was designed and distributed to gather data on the current levels of disaster and business continuity planning. The survey design sought to establish the level of risk assessment across the organisations and the integration of property management into the disaster planning process. Findings This paper describes the current climate change predictions and the likely consequences for building assets in the face of extreme weather events. It reveals that a significant number of public sector authorities are not preparing integrated disaster management plans nor business continuity plans. There is a need for further research into the impact on assets and the role of the public sector real estate manager in assessing the risks and developing strategies to prepare the organisation and to mitigate the effects of natural disasters and severe weather events. Originality/value This research highlights the potential for climate change to threaten property assets and particularly to compromise the delivery of public services in the event of extreme weather events. The paper highlights the need for integrated risk assessment and disaster planning, which incorporates enabling property assets. Public sector asset managers have a vital role to play in undertaking risk assessment and preparing disaster plans. This role is becoming increasingly important as climate change is predicted to have a significant effect on the frequency of extreme weather events and the occurrence of natural disasters.
Recent Advances in Avalanche Photodiodes (2015)

Until the early 2000's, the avalanche photodiode (APD) was widely deployed in high-performance optical receivers that operated up to 10 Gb/s. In subsequent years, the use of APDs for high-capacity systems declined as a result of their limited gain bandwidth, the transition to coherent detection, and the development of high-efficiency modulation techniques. Recently, the rapid growth of optical-fiber communications systems that utilize baud rates up to 25 Gb/s represented by a 100-Gb/s Ethernet has led to a resurgence of research on APDs and the development of low-noise APDs with enhanced gain bandwidth. This paper presents a brief review of APD fundamentals and describes some of the recent advances.
Streptohydrazid (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStreptohydrazidFrank C. Pennington, Peter A. Guercio, and I. A. SolomonsCite this: J. Am. Chem. Soc. 1953, 75, 9, 2261Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ja01105a514https://doi.org/10.1021/ja01105a514research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Chemistry and Metallurgy of Miscellaneous Materials: Thermodynamics (1950)

This book deals primarily with the thermodynamic properties of a large number of compounds and elements. Tables of heat contents, vapor pressures, heats of vaporization and entropies of vaporization for more than sixty elements have been compiled. Thermodynamic and physical properties of nitrides, carbides, sulfides, silicides, phosphides, halides and common gases are also given. The results of the investigation of the liquidsolid equilibriums of the two-component systems composed of the bromides and iodides of barium and strontium and the temperature-composition diagrams of metal-metal halide systems are discussed. A total of ten papers is included in the book. Each paper contains a comprehensive list of references. The book, which is a part of the National Nuclear Energy Series, will be of interest mainly to the physicist and physical chemist.
Characterization of scaled SONOS EEPROM memory devices for space and military systems (2005)

We present recent results on an integrated radiation-hardened technology, which consists of scaled silicon-oxide-nitride-oxide-silicon (SONOS) nonvolatile semiconductor memory (NVSM) and bulk CMOS devices - devices designed specifically for high-density, 1 Mb EEPROMs operating in space and military environments. These devices operate at low-voltage (+7V, 2.5 ms write, -7V, 7.5 ms erase) with 10-year retention at 150C and greater than 10/sup 5/ erase/write cycles. We describe erase/write, retention and endurance results over a 22-250C temperature range with a tunnel oxide of 1.8 nm, 'oxynitride' of 6.5 nm, and a blocking or 'cap' oxide of 3.0 nm. These scaled SONOS devices exhibit an extrapolated 10-year memory window of 1.2V (22C) and acceptable 0.3V (150C). A SONOS retention model is presented, which includes charge loss from both direct tunneling and thermal excitation. We discuss recent results of a radiation-hardened 1Mb SONOS EEPROM and its memory cell. In addition, we discuss experiments on 'localized' charge storage with hot electron injection to write SONOS/NROM/spl trade/ memory devices for higher functional density with increased retention.
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6 (2017)

The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We used a structure-based drug design to develop highly potent compounds that block this interaction. A subset of these inhibitors also causes rapid ubiquitylation and degradation of BCL6 in cells. These compounds display significantly stronger induction of expression of BCL6-repressed genes and anti-proliferative effects than compounds that merely inhibit co-repressor interactions. This work establishes the BTB domain as a highly druggable structure, paving the way for the use of other members of this protein family as drug targets. The magnitude of effects elicited by this class of BCL6-degrading compounds exceeds that of our equipotent non-degrading inhibitors, suggesting opportunities for the development of BCL6-based lymphoma therapeutics.
Paternal Age and Preeclampsia (2002)

Paternal aging is associated with premeiotic damage to spermatogonia, a mechanism by which new point mutations are introduced into the gene pool. We hypothesized that paternal age might contribute to preeclampsia.We studied the incidence of preeclampsia in 81,213 deliveries surveyed in 1964-1976 in the Jerusalem Perinatal Study. We controlled for maternal age, parity and other risk factors using logistic regression.Preeclampsia was reported in 1303 deliveries (1.6%). Compared with fathers age 25-34 years, the odds ratios (ORs) for preeclampsia were 1.24 (95% confidence interval = 1.05-1.46) for age 35-44 and 1.80 (1.40-2.31) for age 45+. For fathers age <25, the OR was 1.25 (1.04-1.51). Although weaker than maternal age effects, paternal effects were consistent within subgroups of other variables.These findings support the hypothesis that a modest proportion of preeclampsia might be explained by new mutations acquired from fathers and add to a growing body of evidence for paternal age effects in birth defects, neuropsychiatric disease and neoplasia.
An Analysis of the Prognostic Value of IDH1 (Isocitrate Dehydrogenase 1) Mutation in Polish Glioma Patients (2013)

Our results indicate the usefulness of assessing the R132H IDH1 mutation in glioma patients: the presence or absence of the R132H mutation can help pathologists to distinguish pilocytic astrocytomas (IDH1 WT) from diffuse ones (R132H IDH1/WT). Moreover, low IDH1 p.R132H expression was related to better prognosis. This clinical implication appears to be important for personalization of prognosis and treatment by oncologists.
Metal-catalysed halogen exchange reactions of aryl halides (2009)

Aryl halides are common synthetic targets themselves, and also highly versatile synthetic intermediates. Aryl chlorides are much more widely available and easier to synthesise than the other halide derivatives, so the development of effective methods for interconverting aryl halide derivatives would therefore be extremely useful. This article outlines which transformations are particularly desirable, and describes the progress that has been made on developing methods for carrying out those transformations using copper, nickel or palladium catalysts. The possible mechanisms of these reactions are discussed, with a view to identifying areas for future investigation.
An Improved Identity-Based Group Signature Scheme (2009)

In a group signature scheme, a group member signs messages anonymously on behalf of the group. However, in the case of a dispute, the actual group signer's identity can be revealed by a designated entity. In this paper, we propose a new identity-based group signature scheme using bilinear maps. The group signature scheme is well suited for large groups, i. e., the length of the group' s public key and the length of signatures are independent on the size of the group. Our signature scheme is based on bilinear maps. Furthermore, a group member can sign many messages using the same key pair. Cryptanalysis shows that the proposed group signature scheme is secure under the computational Diffie Hellman problem called CDHP assumption. And it is also more efficient than previous ones satisfying these requirements.
Integrated Photonic Circuits in Gallium Nitride and Aluminum Nitride (2014)

Integrated optics is a promising optical platform both for its enabling role in optical interconnects and applications in on-chip optical signal processing. In this paper, we discuss the use of group III-nitride (GaN, AlN) as a new material system for integrated photonics compatible with silicon substrates. Exploiting their inherent second-order nonlinearity we demonstrate and second, third harmonic generation in GaN nanophotonic circuits and high-speed electro-optic modulation in AlN nanophotonic circuits.
Conservation of Intrinsic Disorder in Protein Domains and Families:  I. A Database of Conserved Predicted Disordered Regions (2006)

Many protein regions have been shown to be intrinsically disordered, lacking unique structure under physiological conditions. These intrinsically disordered regions are not only very common in proteomes, but also crucial to the function of many proteins, especially those involved in signaling, recognition, and regulation. The goal of this work was to identify the prevalence, characteristics, and functions of conserved disordered regions within protein domains and families. A database was created to store the amino acid sequences of nearly one million proteins and their domain matches from the InterPro database, a resource integrating eight different protein family and domain databases. Disorder prediction was performed on these protein sequences. Regions of sequence corresponding to domains were aligned using a multiple sequence alignment tool. From this initial information, regions of conserved predicted disorder were found within the domains. The methodology for this search consisted of finding regions of consecutive positions in the multiple sequence alignments in which a 90% or more of the sequences were predicted to be disordered. This procedure was constrained to find such regions of conserved disorder prediction that were at least 20 amino acids in length. The results of this work included 3,653 regions of conserved disorder prediction, found within 2,898 distinct InterPro entries. Most regions of conserved predicted disorder detected were short, with less than 10% of those found exceeding 30 residues in length.
Atmospheric Pressure CO<sub>2</sub> Pulsed Laser with Semiconducting Plastic Electrodes (1972)

The characteristics of a TEA laser with a new type of electrode have been investigated in a preliminary study. The method used consisted of replacing the discrete discharge elements by smooth semiconducting plastic electrodes which allow good control of the discharge, greater injection of CO 2 , and greater excitation cross section than the discrete discharge elements, and produce a plasma with good optical properties.
An accurate small-range IC temperature transducer (1980)

A new IC temperature transducer is described. Main features are: easy calibration, high-output voltage (100 mV//spl deg/C), low-output impedance (70 /spl Omega/), high accuracy (/spl plusmn/0.1/spl deg/C; 20-50/spl deg/C) and low-power dissipation (250 /spl mu/W). The new device, which uses the intrinsic bandgap voltage of silicon as a reference, is especially suited to clinical use.
An Electrical and Optical Characteristics of the Color ac Plasma Displays with a New Cell Structure (I) (1999)

A new type ac plasma display panel(PDP) cells are designed and tested electrically and optically. These cells have the a long discharge path length and a small electrode area. They show a higher luminous efficiency and a lower power consumption about 30-40% improvement than the conventional standard ac PDP cells.
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection (2017)

Helicobacter pylori (H. pylori) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-inflammatory medication, unexplained iron deficiency anemia, and idiopathic thrombocytopenic purpura. While choosing a treatment regimen for H. pylori, patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process. For first-line treatment, clarithromycin triple therapy should be confined to patients with no previous history of macrolide exposure who reside in areas where clarithromycin resistance amongst H. pylori isolates is known to be low. Most patients will be better served by first-line treatment with bismuth quadruple therapy or concomitant therapy consisting of a PPI, clarithromycin, amoxicillin, and metronidazole. When first-line therapy fails, a salvage regimen should avoid antibiotics that were previously used. If a patient received a first-line treatment containing clarithromycin, bismuth quadruple therapy or levofloxacin salvage regimens are the preferred treatment options. If a patient received first-line bismuth quadruple therapy, clarithromycin or levofloxacin-containing salvage regimens are the preferred treatment options. Details regarding the drugs, doses and durations of the recommended and suggested first-line and salvage regimens can be found in the guideline.
Fuel Reformation: Catalyst Requirements in Microchannel Architectures (2005)

Microchannel reactors have unique capabilities for onboard hydrocarbon fuel processing, due to their ability to provide process intensification through high heat and mass transfer, leading to smaller and more efficient reactors. The catalyst requirements in microchannel devices are demanding, requiring high activity, very low deactivation rates, and strong adherence to engineered substrate. Each unit operation benefits from microchannel architecture: the steam reforming reactor removes heat transfer limitations, allowing the catalyst to operate at elevated temperatures at the kinetic limit; the water gas shift reactor uses unique temperature control to reduce catalyst volume requirements; the PROX reactor provides high CO conversion and minimizes H2 oxidation through effective control of reactor temperature.
Holographic three-dimensional display synthesized from three-dimensional Fourier spectra of real existing objects (2003)

A method of synthesizing computer-generated holograms of real existing objects is proposed that is based on a series of projection images of an incoherently illuminated object recorded from different perspectives. In accordance with the principles of computer tomography, the three-dimensional Fourier spectrum of the object is calculated by use of several projection images. A method of calculating a Fresnel hologram from the three-dimensional Fourier spectrum is proposed. Experimental results in the form of a computer simulation and optical reconstruction are presented.
The Effect of Compositional Tailoring on the Thermal Expansion and Tribological Properties of PS300: A Solid Lubricant Composite Coating (1997)

This paper describes a research program in which the goal is to alter the thermal expansion coefficient of a composite solid lubricant coating PS300, by compositional tailoring. PS300 is a plasma-sprayed coating consisting of chrome oxide, silver and barium fluoride/calcium fluoride eutectic in NiCr binder. By adjusting the composition, the thermal expansion coefficient can be altered, and hence chosen, to more closely match a selected substrate preventing coating spallation at extreme temperatures. Thermal expansion coefficients (CTEs) for a variety of compositions were measured from 25° to 800°C using a commercial dilatometer. The CTEs ranged from 7.0 to 13 × 10−6/°C depending on the binder content. Subsequent tribological testing of a modified composition indicated that friction and wear properties were generally comparable, and for some operating conditions superior, to the original composition.
Influence of surface roughness on the quartz crystal microbalance response in a solution New configuration for QCM studies (1997)

The effect of surface roughness on a quartz crystal microbalance (QCM) response in contact with a liquid has been investigated. A perturbation theory was used for the description of the effect of slight roughness and an approach based on Brinkman's equation was used for strongly rough surfaces. In the latter approach, one treats the flow of a liquid through a non-uniform surface layer as the flow of a liquid through a porous medium. Our description includes both the effect of viscous dissipation in the interfacial layer and the effect of the liquid mass rigidly coupled to the surface. A relation between QCM response and the interface geometry has been found. We suggested a new approach to study the QCM response in liquids that provides an effective way to analyse the effect of roughness. The models discussed here can be used for the treatment of QCM response of rough electrode surfaces, of porous deposited films, and of surface polymer films.
Robust servo design for tape transport (2002)

This paper concerns the robust servo design for a direct drive tape transport testbed. The goal of the control system is to use two independently driven reels of the transport to maintain accurate speed and tension of the tape over range of 0.5-20m/sec and 0.25-2N(1-8oz). This multi-input/multi-output (MIMO) system has dynamics that make achieving these specifications difficult. These dynamics include slowly time-varying dynamics due to changing tape pack radii, stiction causing stick-slip phenomenon during start-up, air entrainment dynamics that rapidly and nonlinearly change spring constants in the system, and the periodic disturbances with time varying frequencies. There are basically two approaches to cope with the nonlinear and time-varying dynamics: gain scheduling and robust control. This paper examines the robust control algorithms for the tape transport, including H/sup /spl infin// mixed sensitivity approach to obtain robust stability and disturbance observer (DO) architecture for the robust performance. The experimental data are presented to show the effectiveness of the algorithms.
Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect. (1988)

Madin-Darby canine kidney (MDCK) cells are highly differentiated and have retained the morphogenetic properties necessary to form polarized, multicellular epithelial structures (cysts) in vitro that resemble epithelial tissues in vivo. We introduced the c-src gene into MDCK cells to elevate the level of the plasma membrane-associated cellular tyrosine kinase, pp60c-src, to levels two- to ninefold higher than that expressed in parent MDCK cells. Our results revealed a highly discriminatory biological action of pp60c-src on the morphogenetic properties of MDCK cells. Elevated expression of pp60c-src conferred on MDCK cells the ability to undergo dramatic changes of cell shape that includes the formation of long cell processes (100 to 200 microns), never observed in control MDCK cells. The morphogenesis of multicellular epithelial cysts was altered by elevated levels of pp60c-src and led to predictable distortions of their three-dimensional architecture. However, these cells established morphologically normal cell polarity, formed adhesive epithelial cell-cell contacts indistinguishable from those of control MDCK cells, and exhibited neither focus-forming ability or anchorage-independent growth potential. Finally, we showed that MDCK cells expressing elevated levels of pp60c-src exhibit increased phosphorylation of a more limited number of phosphotyrosine-containing proteins than MDCK cells expressing pp60v-src. We suggest that a natural function of pp60c-src is to regulate the morphogenetic properties which determine the shape of differentiated cells and multicellular structures.