gebhart/patrepeval huggingface dataset:
Potential Molecular Mechanism for c-Src Kinase-mediated Regulation of Intestinal Cell Migration (2008)

The ubiquitously expressed Src tyrosine kinases (c-Src, c-Yes, and c-Fyn) regulate intestinal cell growth and differentiation. Src activity is also elevated in the majority of malignant and premalignant tumors of the colon. The development of fibroblasts with the three ubiquitously expressed kinases deleted (SYF cells) has identified the role of Src proteins in the regulation of actin dynamics associated with increased cell migration and invasion. Despite this, unexpectedly nothing is known about the role of the individual Src kinases on intestinal cell cytoskeleton and/or cell migration. We have previously reported that villin, an epithelial cell-specific actin-modifying protein that regulates actin reorganization, cell morphology, cell migration, cell invasion, and apoptosis, is tyrosine-phosphorylated. In this report using the SYF cells reconstituted individually with c-Src, c-Yes, c-Fyn, and wild type or phosphorylation site mutants of villin, we demonstrate for the first time the absolute requirement for c-Src in villin-induced regulation of cell migration. The other major finding of our study is that contrary to previous reports, the nonreceptor tyrosine kinase, Jak3 (Janus kinase 3), does not regulate phosphorylation of villin or villin-induced cell migration and is, in fact, not expressed in intestinal epithelial cells. Further, we identify SHP-2 and PTP-PEST (protein-tyrosine phosphatase proline-, glutamate-, serine-, and threonine-rich sequence) as negative regulators of c-Src kinase and demonstrate a new function for these phosphatases in intestinal cell migration. Together, these data suggest that in colorectal carcinogenesis, elevation of c-Src or down-regulation of SHP-2 and/or PTP-PEST may promote cancer metastases and invasion by regulating villin-induced cell migration and cell invasion.
Structure of the Genome Termini of Varicella-Zoster Virus (1984)

The DNA molecule of varicella-zoster virus (VZV) is represented structurally as L-S, where L is a unique sequence and S is a unique sequence flanked by an inverted repeat. S may be present in either orientation in virion DNA molecules, but, to date, L has been found in only one orientation. DNA sequences were determined at the L-S joint and genome termini, which were cloned using methods designed to conserve either the 3' or 5' terminal nucleotide. Molecular hybridization experiments and analysis of the sequences showed that: the genome is not terminally redundant; the unique sequence in L is flanked by an inverted repeat of 88.5 base pairs; a single unpaired nucleotide is located at each 3' terminus of the genome, such that fusion of the termini would produce a sequence identical to that at the L-S joint; approx. 5% of virions contain genomes with L inverted. The implications of these results in possible mechanisms for VZV DNA replication are discussed.
Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture (1995)

This study focuses on the effect of static and dynamic mechanical compression on the biosynthetic activity of chondrocytes cultured within agarose gel. Chondrocyte/agarose disks (3 mm diameter) were placed between impermeable platens and subjected to uniaxial unconfined compression at various times in culture (2-43 days). [35S]sulfate and [3H]proline radiolabel incorporation were used as measures of proteoglycan and protein synthesis, respectively. Graded levels of static compression (up to 50%) produced little or no change in biosynthesis at very early times, but resulted in significant decreases in synthesis with increasing compression amplitude at later times in culture; the latter observation was qualitatively similar to that seen in intact cartilage explants. Dynamic compression of approximately 3% dynamic strain amplitude (approximately equal to 30 microns displacement amplitude) at 0.01-1.0 Hz, superimposed on a static offset compression, stimulated radiolabel incorporation by an amount that increased with time in culture prior to loading as more matrix was deposited around and near the cells. This stimulation was also similar to that observed in cartilage explants. The presence of greater matrix content at later times in culture also created differences in biosynthetic response at the center versus near the periphery of the 3 mm chondrocyte/agarose disks. The fact that chondrocyte response to static compression was significantly affected by the presence or absence of matrix, as were the physical properties of the disks, suggested that cell-matrix interactions (e.g. mechanical and/or receptor mediated) and extracellular physicochemical effects (increased [Na+], reduced pH) may be more important than matrix-independent cell deformation and transport limitations in determining the biosynthetic response to static compression. For dynamic compression, fluid flow, streaming potentials, and cell-matrix interactions appeared to be more significant as stimuli than the small increase in fluid pressure, altered molecular transport, and matrix-independent cell deformation. The qualitative similarity in the biosynthetic response to mechanical compression of chondrocytes cultured in agarose gel and chondrocytes in intact cartilage further indicates that gel culture preserves certain physiological features of chondrocyte behavior and can be used to investigate chondrocyte response to physical and chemical stimuli in a controlled manner.
Surface Phenomena and Additives in Water-Based Coatings and Printing Technology (1991)

Water-based technology has undergone revolutionary changes during the past two decades. Interest in the properties and uses of water-based coatings, paints and inks has continued to grow since the est
Anomalous Dispersion Relations by Symmetry Breaking in Axially Uniform Waveguides (2004)

We show that modes of axially uniform waveguides of arbitrary cross section can be made to have anomalous dispersion relations resulting from strong repulsion between two modes. When the axial wave vector k is 0, the two modes have different TE/TM symmetry and thus can be brought arbitrarily close to an accidental frequency degeneracy. For nonzero k, the symmetry is broken causing the modes to repel. When the modes are sufficiently close together this repulsion leads to unusual features such as extremely flattened dispersion relations, backward waves, zero group velocity for nonzero k, atypical divergence of the density of states, and nonzero group velocity at k=0.
Investigation of new material combinations for hard x-ray telescope designs (2006)

The materials chosen for depth graded multilayer designs for hard x-ray telescopes (10 keV to 80 keV) have until now been focusing on W/Si, W/SiC, Pt/C, and Pt/SiC. These material combinations have been chosen because of good stability over time and low interface roughness, However both W and Pt have absorption edges in the interesting energy range from 70 - 80 keV. If looking at the optical constants Cu and Ni would be good alternative high-Z candidates since the k-absorption edges in Cu and Ni is below 10 keV. We have investigated both of these materials as the reflecting layer in combination with SiC as the spacer layer and give the performance in terms of roughness, minimum obtainable d-spacing and stability over time as deposited in our planar magnetron sputtering facility. Likewise we review the same properties of WC/SiC coatings which we have previously developed and which allow for very small d-spacings. The combination of WC/SiC or the well established W/SiC with the above mentioned Cu and Ni-containing multilayers in the same stack allows for novel telescope designs operating up to and above 100 keV without the absorption edge structure.
Geometrical Properties and Torsional Fatigue Life of a Tibial Interlocking Intramedullary Nail Segment (1998)

Tibial IM nails with hourglass cross-sectional shape and fabricated of Ti-6Al-4V or Ti-13Nb-13Zr alloy, having appropriate mechanical, thermal, and surface treatments, may be competitive with the current "gold standard" (namely cloverleaf cross-section and fabricated of 316L stainless steel in the cold-worked state).
Volatile compounds of tomato fruit and plant parts: relationship and biogenesis (1993)

A comparison is made of the volatile component concentrations in the macerated (blended) forms of tomato fruit and leaf and to a lesser extent in macerated flower, calyx and stem. These studies show that some processes such as the formation of C6 lipid derived volatiles are similar between fruit and leaf. Formation of higher carbon number lipid derived volatiles (e.g. 4,5-epoxy-(E)-2-decenal), however, only occurs in the fruit. Other processes such as the formation of carotenoid related (e.g. 6-methyl-5-hepten-2- one) and amino acid related (e.g. nitro, nitrile and thiazole) volatiles seem to be largely confined to the fruit. Terpenoid hydrocarbons occur in the leaf but not the fruit, except for (-)-alpha-copaene in the mature green fruit. Lipid oxidation processes occur in the first few minutes after maceration but glycoside hydrolysis and amino acid derived volatile biogenesis seems to occur during the ripening process in the intact tomato
Common industry myths about magnetic drive pumps (2004)

Recently, the pump industry has not been kind to magnetic drive pumps, with rumours about their suitability, reliability and affordability circulating amongst a slew of other inaccuracies that have been deterring some buyers. In this article we feature an interview with David Clark, senior engineering manager at HMD/Kontro Sealless Pumps who puts the record straight.
Poly(anthraquinonyl sulfides): High Capacity Redox Polymers for Energy Storage (2018)

Redox polymers with high energy storage capacity are searched in order to diminish the weight to the actual batteries. Poly(anthraquinonyl sulfide) PAQS is a popular redox polymer which has shown a high performance cathode for lithium, sodium and magnesium batteries. Although PAQS cathodes show high cycling stability it has a relatively low theoretical specific capacity of 225 mAh/g. In this paper we show the synthesis and characterization of new poly(anthraquinonyl sulfides) PAQxS in an attempt to improve the specific capacity of PAQS. Thus, a series of PAQxS polymers with different polysulfide segment lengths (x between 2 and 9 sulfur atoms) have been synthesized in high yields by reacting in situ formed sodium polysulfides with 1,5-dicholoroanthraquinone. The poly(anthraquinonyl sulfides) powders were characterized by ATR-FTIR, solid state 13C NMR for the organic part and Raman spectroscopy for the chalcogenide part. This characterization confirmed the chemical structure of the PAQxS based on an anthraquinone moiety bind together by polysulfide segments. The electrochemical characterization showed a dual reversible redox mechanism associated with both the anthraquinone and polysulfide electrochemistry. Finally, lithium coin cell battery test of the PAQxS redox polymers as cathodes indicated that the capacity of poly(anthraquinonyl sulfides) showed very high experimental initial capacity values above 600 mAh/g, less capacity loss than sulfur cathodes, and higher steady state capacity than PAQS.
Generating Natural Language Descriptions From Tables (2020)

This paper proposes a neural generative architecture, namely NLDT, to generate a natural language short text describing a table which has formal structure and valuable information. Specifically, the architecture maps fields and values of a table to continuous vectors and then generates a natural language description by leveraging the semantics of a table. The NLDT architecture adopts a two-level neural model to make the most of the structure of a table to fully express the relationship between contents. To deal with the problem of out-of-vocabulary, this paper develops a simple and fast word-conversion method that replaces rare words appearing in texts with common field information in tables and directly replicates contents from table to the output sequence according to the field information. Besides, this paper adds the concept of theme to adapt the NLDT architecture to open domain and improves beam search algorithm to strengthen the results in the inference stage. On the WEATHERGOV dataset, the NLDT architecture improves the state-of-the-art BLEU-4 score from 61.01 to 62.89 and the current state-of-the-art F1 score from 73.21 to 78. On the WIKIBIO and WIKITABLE datasets, the NLDT architecture achieves a BLEU-4 score of 45.77 and 38.71 respectively which also outperform the state-of-the-art approaches. Furthermore, this paper introduces a Chinese dataset WIKIBIOCN including 33,244 biographies with corresponding tables. On the WIKIBIOCN dataset, the NLDT architecture achieves a BLEU-4 score of 38.87 and fairly good manual evaluation.
256-QAM Modem Performance in Distorted Channels (1985)

Performance degradations of 256-QAM modems in distorted channels are studied in this correspondence. Illustrative linear, parabolic, and sinusoidal amplitude and group delay channel distortions, caused by filter imperfections and/or by selective radio fades, are investigated. To enable an easy comparison with 64-QAM systems, we present the degradations of these systems in the same figures as those of 256-QAM modems. It is shown that linear (slope) group delay and sinusoidal (ripple) amplitude distortions cause the most significant performance degradations.
[<sup>3</sup>H](2<i>S</i>,4<i>R</i>)‐4‐Methylglutamate: a novel ligand for the characterization of glutamate transporters (2001)

[(3)H](2S,4R)-4-Methylglutamate ([(3)H]4MG), used previously as a ligand for low-affinity kainate receptors, was employed to establish a binding assay for glutamate transporters (GluTs), as 4MG has also been shown to have affinity for the glial GluTs, GLT1 and GLAST. In rat brain membrane homogenates in the presence of Na(+) ions at 4 degrees C, specific binding of [(3)H]4MG was rapid and saturable (t(1/2) approximately 15 min), representing > 90% of total binding. Dissociation of [(3)H]4MG occurred in a biphasic manner, however, saturation studies and Scatchard analysis indicated a single site of binding (n(H) = 0.85) and a K(d) of 6.2 +/- 0.8 microM with a B(max) of 111.8 +/- 23.8 pmol/mg protein. Specific binding of [(3)H]4MG was Na(+)-dependent and inhibited by K(+) and HCO(3-). Pharmacological inhibition with compounds acting at GluTs revealed that Glu, D- and L-aspartate, L-serine-O-sulfate and Ltrans-pyrrolidine-2,4-dicarboxylate fully displaced specific binding. Drugs having preferential affinity for GLT1, kainate, dihydrokainate and Lthreo-3-methylglutamate, all inhibited approximately 40% of specific binding. The inhibition pattern of L-serine-O-sulfate in the presence of a saturating concentration of dihydrokainate was suggestive of [(3)H]4MG also labelling GLAST. 6-Cyano-7-nitroquinoxaline, a kainate receptor antagonist, and a range of Glu receptor agonists and antagonists failed to significantly inhibit [(3)H]4MG binding. The pharmacological profile of binding of [(3)H]4MG resembled that found for [(3)H]D-aspartate, a ligand specific for GluTs, reinforcing the hypothesis that [(3)H]4MG was labelling GluTs in this assay. Together, these data illustrate the development of an efficient, economic binding assay that is suitable for the characterization of different subtypes of GLuTs.
Mitomycin C-induced expression of trpA of Salmonella typhimurium inserted into the plasmid ColE1 (1977)

EcoRI endonuclease digestion of the deoxyribonucleic acid of a phi80 transducing phage carrying the entire tryptophan (trp) operon of Salmonella typhimurium (phi80 S.t.trpE-A) yielded a 4.3 X 10(6)-dalton fragment containing intact trpE, trpD, and trpC and a 3.35 X 10(6)-dalton fragment containing intact trpA. The trpA fragment inserted into EcoRI-cleaved plasmids ColE1 and CR1 was expressed regardless of its orientation of insertion. Mitomycin C, a compound that induces colicin E1 production in ColE1-containing bacteria, stimulated tryptophan synthetase alpha production in cells containing ColE1-TRPA plasmids with the trpA fragment inserted in one orientation but not the other. We conclude that in the inducible plasmids trpA can be expressed from the colicin E1 promoter.
Resonant Matter Wave Amplification in Mean Field Theory (2011)

We develop a Green's function based mean-field theory for coherent mixing of matter- and light-waves. To demonstrate the utility of this approach, we analyse a co-propagating Raman matter-wave amplifier. We find that for a given laser intensity, a significantly faster amplification process can be achieved employing resonant rather than off-resonance driving. The ratio of the matter-wave gain to atom loss-rate due to spontaneous emission is given by the optical depth of the sample, and is the same both on- and off-resonance. Furthermore, we show that for short-times, the single-mode approximation for the matter-waves gives exact agreement with the full spatial dynamics. For long times, the off-resonant case shows suppressed amplification due to a spatially inhomogenous AC Stark shift associated with laser depletion. This suppression is absent on-resonance, where the AC Stark shift is absent.
An electronic book for accessing and organising information distributed across Internet: Dynamic WAIS Book (1995)

The authors describe the work that they have been undertaking in their 'Virtual Electronic Library' project. Initially, two basic types of electronic book were studied: Hyper-book and Visual-book. A description of the main features of these books is included together with a particular type of Hyper-book-the 'Dynamic WAIS Book'. Such books follow the same basic design principles as Hyper-books and provide a powerful publishing environment based on the acquisition of electronic texts from the Internet using the Wide Area Information Service (WAIS) protocol. The Dynamic WAIS Book allows a user to search for publicly available Internet information, retrieve it and organise it in the form of a personal virtual electronic library.
Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1α (2000)

Mammalian cells are able to sense oxygen and regulate a number of genes in response to hypoxia. The transcription factor Hypoxia Inducible Factor-1 (HIF-1) was identified as an important key component of the hypoxia signaling pathway. HIF-1 is a heterodimer composed of two members of the basic helix-loop-helix transcription factor superfamily containing a PAS (PER-ARNT-SIM) domain: HIF-1alpha and HIF-1beta/ARNT. During the cloning by reverse transcriptase-polymerase chain reaction of the human HIF-1alpha subunit, we isolated two cDNA clones which corresponded to alternative splicing of the HIF-1alpha gene. Polymerase chain reaction analysis and sequencing revealed that both clones possessed three additional base pairs between exons 1 and 2. Also, one of them lacked 127 base pairs corresponding to exon 14. We demonstrate that the mRNA of this truncated form is expressed in several human cells lines and human skin but apparently not in rodents. When transfected in HEK 293 cells, the corresponding 736 amino acid protein (HIF-1alpha(736)) is regulated by hypoxia in a similar manner as the full-length HIF-1alpha (HIF-1alpha(FL)). In luciferase transfection assays, both recombinant proteins HIF-1alpha(736) and HIF-1alpha(FL) dimerize with HIF-1beta/ARNT and activate the VEGF promoter upon hypoxia. However, the shorter HIF-1alpha isoform is 3-fold less active than HIF-1alpha(FL), a result consistent with the lack of the C-terminal transactivation domain. As expected, this small isoform can compete with the endogenous and transfected full-length HIF-1alpha. Altogether, these results suggest that the HIF-1alpha(736) isoform modulates gene expression upon hypoxia.
Immunohistochemical Distinction of Follicular Thyroid Adenomas and Follicular Carcinomas (2008)

Protein expression data validate the pooled gene expression results that differentiate FTC from FA. Our results show promise for multiple-protein IHC analysis algorithms and their diagnostic ability. Future studies should focus on clinical translation of these molecular differences for the diagnosis of follicular thyroid neoplasms.
Selective Alteration of Personality and Social Behavior by Serotonergic Intervention (1998)

Central serotonergic function may modulate a dimension of normal personality characterized by reduced negative affective experience and increased affiliative behavior. SSRI administration has significant and detectable effects on these measures even in the absence of baseline clinical depression or other psychopathology.
Direct effects of diazoxide on mitochondria in pancreatic B‐cells and on isolated liver mitochondria (1998)

1. The direct effects of diazoxide on mitochondrial membrane potential, Ca2+ transport, oxygen consumption and ATP generation were investigated in mouse pancreatic B-cells and rat liver mitochondria. 2. Diazoxide, at concentrations commonly used to open adenosine 5'-triphosphate (ATP)-dependent K+-channels (K(ATP) channels) in pancreatic B-cells (100 to 1000 microM), decreased mitochondrial membrane potential in mouse intact perifused B-cells, as evidenced by an increase of rhodamine 123 fluorescence. This reversible decrease of membrane potential occurred at non-stimulating (5 mM) and stimulating (20 mM) glucose concentrations. 3. A decrease of mitochondrial membrane potential in perifused B-cells was also caused by pinacidil, but no effect could be seen with levcromakalim (500 microM each). 4. Measurements by a tetraphenylphosphonium-sensitive electrode of the membrane potential of rat isolated liver mitochondria confirmed that diazoxide decreased mitochondrial membrane potential by a direct action. Pretreatment with glibenclamide (2 microM) did not antagonize the effects of diazoxide. 5. In Fura 2-loaded B-cells perifused with the Ca2+ channel blocker, D 600, a moderate, reversible increase of intracellular Ca2+ concentration could be seen in response to 500 microM diazoxide. This intracellular Ca2+ mobilization may be due to mitochondrial Ca2+ release, since the reduction of membrane potential of isolated liver mitochondria by diazoxide was accompanied by an accelerated release of Ca2+ stored in the mitochondria. 6. In the presence of 500 microM diazoxide, ATP content of pancreatic islets incubated in 20 mM glucose for 30 min was significantly decreased by 29%. However, insulin secretion from mouse perifused islets induced by 40 mM K+ in the presence of 10 mM glucose was not inhibited by 500 microM diazoxide, suggesting that the energy-dependent processes of insulin secretion distal to Ca2+ influx were not affected by diazoxide at this concentration. 7. The effects of diazoxide on oxygen consumption and ATP production of liver mitochondria varied depending on the respiratory substrates (5 mM succinate, 10 mM alpha-ketoisocaproic acid, 2 mM tetramethyl phenylenediamine plus 5 mM ascorbic acid), indicating an inhibition of respiratory chain complex II. Pinacidil, but not levcromakalim, inhibited alpha-ketoisocaproic acid-fuelled ATP production. 8. In conclusion, diazoxide directly affects mitochondrial energy metabolism, which may be of relevance for stimulus-secretion coupling in pancreatic B-cells.
Flux and winding current balancing control for a medium-frequency six-winding transformer (2014)

Solid state transformers normally include a transformer whose operating frequency is well above the usual grid frequencies. These transformers are supplied by power electronic inverters such as an H-bridge. The average value of transformer supply voltage can drift to a non-zero value which may lead to saturation of the magnetic core. This paper presents an active control method to prevent saturation of a multi-winding medium-frequency transformer. The control method comprises two control loops: the first balances the flux of the transformer and the other balances the currents in different windings. Simulation results which show the feasibility of the proposed control method are shown.