gebhart/patrepeval huggingface dataset:
Post-fault operation of an asymmetrical six-phase induction machine with single and two isolated neutral points (2013)

The paper presents a study of post-fault control for an asymmetrical six-phase induction machine with single and two isolated neutral points, during single open-phase fault. Post-fault control is based on the normal decoupling transformation, so that reconfiguration of the controller is minimised. Effect of the single open-phase fault on the machine equations under this control structure is discussed. Different modes of post-fault operation are analysed and are further compared in terms of the achievable torque and stator winding losses. Validity of the analysis is verified using experimental results obtained from a six-phase induction motor drive.
Ketone bodies, glycolysis, and K<sub>ATP</sub> channels in the mechanism of the ketogenic diet (2008)

The ketogenic diet (KD) has shown remarkable efficacy in the treatment of drug-resistant childhood epilepsy. Our understanding of how the KD produces its anticonvulsant and antiepileptogenic effects remains incomplete, which is perhaps not surprising for a biological manipulation as sweeping as dietary change. Several hypotheses focus on ketone bodies, fuel molecules that circulate at millimolar concentrations in the blood of patients on a KD, as causative agents. Here I consider some recent evidence for one such hypothesis, involving a possible role for altered glycolysis and consequent activation of a class of potassium channels called K(ATP)channels.
An 8-bit 2-gigasample/second A/D converter multichip module for digital receiver demonstration on Navy AN/APS-145 E2-C airborne early warning aircraft radar (1998)

This paper will discuss multichip module technology as it is applied to a prototype high performance direct digitizing channelized radar receiver system under development for the Navy's E2-C Airborne Early Warning Aircraft, which encompasses both analog signals at UHF frequencies and multigigahertz digital signals. Critical issues which arise in the design of such a system will be discussed, including thermal management, transmission line design, design of power and ground distribution systems, and analyses of voltage standing wave ratio and simultaneous switching noise. This paper will describe in detail the simulations and analyses which were undertaken during the development of the multichip module containing the analog-to-digital converter and demultiplexer for this system. Finally, test results from measurements of analog-to-digital converter performance at the full operating clock rates of the multichip module will be described, along with lessons learned for the design of subsequent generations of these high performance mixed signal systems.
Over-the-counter Acne Treatments: A Review. (2012)

Acne is a common dermatological disorder that most frequently affects adolescents; however, individuals may be affected at all ages. Many people who suffer from acne seek treatment from both prescription and over-the-counter acne medications. Due to convenience, lower cost, and difficulty getting an appointment with a dermatologist, the use of over-the-counter acne treatments is on the rise. As the plethora of over-the-counter acne treatment options can be overwhelming, it is important that dermatologists are well-versed on this subject to provide appropriate information about treatment regimens and potential drug interactions and that their patients see them as well-informed. This article reviews the efficacy of various over-the-counter acne treatments based on the current literature. A thorough literature review revealed there are many types of over-the-counter acne treatments and each are designed to target at least one of the pathogenic pathways that are reported to be involved in the development of acne lesions. Many of the key over-the-counter ingredients are incorporated in different formulations to broaden the spectrum and consumer appeal of available products. Unfortunately, many over-the-counter products are not well-supported by clinical studies, with a conspicuous absence of double-blind or investigator-blind, randomized, vehicle-controlled studies. Most studies that do exist on over-the-counter acne products are often funded by the manufacturer. Use of over-the-counter acne treatments is a mainstay in our society and it is important that dermatologists are knowledgeable about the different options, including potential benefits and limitations. Overall, over-the-counter acne therapies can be classified into the following five major groups: cleansers, leave-on products, mechanical treatments, essential oils, and vitamins.
Dimerization of the scavenger receptor class B type I (2004)

This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as tissues of transgenic animals and genetically altered steroidogenic and nonsteroidogenic cells overexpressing the SR-B proteins. Using both biochemical and morphological techniques, we have seen that these dimeric and higher order oligomeric forms of SR-BI expression are strongly associated with both functional and morphological expression of the selective HDL cholesteryl ester uptake pathway. Rats and mice show some species differences in expression of SR-BII dimeric forms; this difference does not extend to the use of SR-B cDNA types for transfection purposes. In a separate study, cotransfection of HEK293 cells with cMyc and V5 epitope-tagged SR-BI permitted coprecipitation and quantitative coimmunocytochemical measurements at the electron microscope level, suggesting that much of the newly expressed SR-BI protein in stimulated cells dimerizes and that the SR-BI dimers are localized to the cell surface and specifically to microvillar or double membraned intracellular channels. These combined data suggest that SR-BI self-association represents an integral step in the selective cholesteryl ester uptake process.
Australian Image: The Literary Heritage Re-assessed (1962)

The author discusses Heseltine's critique of Joseph Furphy's 'Such Is Life', and Furphy's theory of the 'futility of human endeavour'. Australian literature is criticised for shying away from the inevitable primal energies of humankind and its concomitant horrors; something writers like Nietzsche embraced.
Sequence dependence of stability for coaxial stacking of RNA helixes with Watson-Crick base paired interfaces (1994)

Thermodynamic parameters from UV melting studies are reported for the helix-helix interfaces of coaxially stacked helixes in RNA. The model system consists of a short oligomer binding to a four-nucleotide overhang at the end of a hairpin stem, creating the helix-helix interface. Interfaces containing Watson-Crick base pairs are approximately 1 kcal/mol more stable than the corresponding nearest neighbor interaction in an uninterrupted helix. Thus the sequence dependence of stability for coaxially stacked interfaces is similar to that for regular helixes. This provides experimental evidence for an assumption that has been shown to improve predictions of RNA secondary structure [Walter, A. E., Turner, D. H., Kim, J., Lyttle, M. H., Muller, P., Mathews, D. H., & Zuker, M. (1994) Proc. Natl. Acad. Sci. U.S.A. (in press)]. The results should also be useful for modeling three-dimensional structures of RNA.
Plant‐derived recombinant immune complexes as self‐adjuvanting <scp>TB</scp> immunogens for mucosal boosting of <scp>BCG</scp> (2014)

Summary Progress with protein‐based tuberculosis ( TB ) vaccines has been limited by poor availability of adjuvants suitable for human application. Here, we developed and tested a novel approach to molecular engineering of adjuvanticity that circumvents the need for exogenous adjuvants. Thus, we generated and expressed in transgenic tobacco plants the recombinant immune complexes ( RIC s) incorporating the early secreted Ag85B and the latency‐associated Acr antigen of Mycobacterium tuberculosis , genetically fused as a single polypeptide to the heavy chain of a monoclonal antibody to Acr. The RIC s were formed by virtue of the antibody binding to Acr from adjacent molecules, thus allowing self‐polymerization of the complexes. TB ‐ RIC s were purified from the plant extracts and shown to be biologically active by demonstrating that they could bind to C1q component of the complement and also to the surface of antigen‐presenting cells. Mice immunized with BCG and then boosted with two intranasal immunizations with TB ‐ RIC s developed antigen‐specific serum IgG antibody responses with mean end‐point titres of 1 : 8100 (Acr) and 1 : 24 300 (Ag85B) and their splenocytes responded to in vitro stimulation by producing interferon gamma. 25% of CD 4+ proliferating cells simultaneously produced IFN ‐γ, IL ‐2 and TNF ‐α, a phenotype that has been linked with protective immune responses in TB . Importantly, mucosal boosting of BCG ‐immunized mice with TB ‐ RIC s led to a reduced M. tuberculosis infection in their lungs from log 10 mean = 5.69 ± 0.1 to 5.04 ± 0.2, which was statistically significant. We therefore propose that the plant‐expressed TB ‐ RIC s represent a novel molecular platform for developing self‐adjuvanting mucosal vaccines.
Structural requirements for neural cell adhesion molecule-heparin interaction. (1990)

Two biological domains have been identified in the amino terminal region of the neural cell adhesion molecule (NCAM): a homophilic-binding domain, responsible for NCAM-NCAM interactions, and a heparin-binding domain (HBD). It is not known whether these two domains exist as distinct structural entities in the NCAM molecule. To approach this question, we have further defined the relationship between NCAM-heparin binding and cell adhesion. A putative HBD consisting of two clusters of basic amino acid residues located close to each other in the linear amino acid sequence of NCAM has previously been identified. Synthetic peptides corresponding to this domain were shown to bind both heparin and retinal cells. Here we report the construction of NCAM cDNAs with targeted mutations in the HBD. Mouse fibroblast cells transfected with the mutant cDNAs express NCAM polypeptides with altered HBD (NCAM-102 and NCAM-104) or deleted HBD (HBD-) at levels similar to those of wild-type NCAM. Mutant NCAM polypeptides purified from transfected cell lines have substantially reduced binding to heparin and fail to promote chick retinal cell attachment. Furthermore, whereas a synthetic peptide that contains both basic amino acid clusters inhibits retinal-cell adhesion to NCAM-coated dishes, synthetic peptides in which either one of the two basic regions is altered to contain only neutral amino acids do not inhibit this adhesion. These results confirm that this region of the NCAM polypeptide does indeed mediate not only the large majority of NCAM's affinity for heparin but also a significant portion of the cell-adhesion-mediating capability of NCAM.
Fusion of computed tomography data and optical 3D images of the dentition for streak artefact correction in the simulation of orthognathic surgery (2004)

The accuracy of the fusion of 3D CT surface data and optical 3D imaging is significantly reduced by metal artefacts. However, it seems appropriate for virtual orthognathic surgery simulation, as post-operative orthodontics are performed frequently.
Lack of early acute rejection does not predict safe tapering of immunosuppression. (1995)

In an effort to reduce long-term complications of immunosuppressive medications, some investigators have devised protocols of reduced dosage [Kupin et al. 1988, Kelly et al. 1989, Reinsmoen et al. 1993] which are intended to maintain the stability of the transplant and at the same time prevent or retard immunosuppressive medication side effects. Implicit in this plan is the assumption that there has been the development of some degree of graft acceptance [Koene 1989] and/or tolerance [Goulmy et al. 1985, Muluk et al. 1991], yet it is also true that drug non-compliance is a common cause of late acute rejection and graft loss in stable kidney recipients [Rao et al. 1988, Didlake et al. 1988, Rao et al. 1989, Hricik et al. 1991]. The latter fact is a warning that immunosuppression should be cautiously and gradually reduced. Patients who reject grafts early tend to require more immunosuppression. It is not known, however, whether patients who do not reject early require less immunosuppression. Herein, we present a case of late acute cellular and vascular rejection that occurred 9 years after stable renal graft function, in the absence of early acute rejection episodes. This case provides evidence to support the notion that lack of early acute rejection may not predict safe reduction of immunosuppression therapy.
Narvis: Authoring Narrative Slideshows for Introducing Data Visualization Designs (2018)

Visual designs can be complex in modern data visualization systems, which poses special challenges for explaining them to the non-experts. However, few if any presentation tools are tailored for this purpose. In this study, we present Narvis, a slideshow authoring tool designed for introducing data visualizations to non-experts. Narvis targets two types of end users: teachers, experts in data visualization who produce tutorials for explaining a data visualization, and students, non-experts who try to understand visualization designs through tutorials. We present an analysis of requirements through close discussions with the two types of end users. The resulting considerations guide the design and implementation of Narvis. Additionally, to help teachers better organize their introduction slideshows, we specify a data visualization as a hierarchical combination of components, which are automatically detected and extracted by Narvis. The teachers craft an introduction slideshow through first organizing these components, and then explaining them sequentially. A series of templates are provided for adding annotations and animations to improve efficiency during the authoring process. We evaluate Narvis through a qualitative analysis of the authoring experience, and a preliminary evaluation of the generated slideshows.
A Nonstationary Model for the Electromyogram (1977)

A theoretical model of the electromyographic (EMG) signal has been developed. In the model, the neural pulse train inputs were considered to be point processes which passed through linear, time-invariant systems that represented the respective motor unit action potential. The outputs were then summed to produce the EMG. It was assumed, that in the production of muscle force, the controlled parameter was the number of active motor units, n(t). The model then showed that the EMG can be represented as an amplitude modulation process of the form EMG = [Kn(t)1/2 w(t) with the stochastic process, w(t), having the spectral and probability characteristics of the EMG during a constant contraction. Various assumptions made in the model development have been verified by experiments.
Effect of taurine on calcium paradox and ischemic heart failure (1981)

The loss of mechanical function in rat hearts subjected to either the calcium-paradox or global ischemia heart failure models was found to correlate with decreases in myocardial taurine levels. Therefore, the effect of taurine treatment was assessed in the two failure procedures. The presence of taurine protected against loss of mechanical function resulting from the calcium paradox and prevented both the large decline in sarcolemmal ATPase activities and the increase in sarcolemmal calcium binding normally associated with this model. Parallel studies on reperfused, taurine-untreated ischemic hearts showed only minor changes in these sarcolemmal functions. Taurine treatment normalized the slight increase in calcium binding associated with ischemia, but had no observable effect on recovery of mechanical function. Although taurine returns selected parameters of the sarcolemma toward normal in both models, it only improves mechanical function in the paradox model. This suggests that calcium paradox-induced heart failure is more closely associated with sarcolemmal dysfunction than ischemic heart failure.
Las relaciones políticas entre España y Cuba: continuidad histórica y ajustes frecuentes (2006)

Gigantomastia is a rare complication of pregnancy usually associated with benign conditions and rarely with malignancies. This paper reports a non-Hodgkin lymphoma case associated with gigantomastia during pregnancy. The patient was a 30-year-old gravida one woman, with a history of rapidly enlarging right breast at 2 weeks prior to presentation. After the first diagnosis of benign gigantomastia, the continuous growth of the breast, despite the delivery and bromocriptine therapy, required further investigation of the case. The histological analysis revealed the presence of Burkitt lymphoma. Malignant causes of unilateral gigantomastia in pregnancy should be considered in the differential diagnosis of this condition.
Activation of Fibrinolysis by SMTP-7 and -8, Novel Staplabin Analogs with a Pseudosymmetric Structure. (2000)

Two novel staplabin analogs, SMTP-7 and -8, have been isolated from cultures of Stachybotrys microspora IFO 30018. Spectroscopic analyses showed that the SMTP-7 molecule consisted of two identical staplabin core structures and ornithine which bridges the two partial structures. In the SMTP-8 molecule, the bridging unit was lysine. At concentrations of 80 approximately 150 microM, the two compounds caused 2- to 12-fold increase in urokinase-catalyzed plasminogen activation, fibrin binding of plasminogen, and urokinase- and plasminogen-mediated fibrinolysis. These activities of SMTP-7 and -8 were two to ten times higher than those of staplabin and previously isolated SMTPs, which exerted such effects at concentrations ranging from 150 to 800 microM.
On-line signature verification based on FIR system characterizing motion pressure (2011)

We propose an on-line signature verification method based on finite impulse response(FIR) system characterizing motion pressure of pen-point trajectory in signing process. The discrete cosine transforms(DCTs) of the handwriting feature is used to reduce the fluctuation and extract the feature of handwriting. The signature verification system is realized by four FIR subsystems. Then motion pressure can be characterized by using the FIR subsystem having the DCTs of the area pressure and motion pressure as the input and the output of the FIR system, respectively. The obtained impulse responses of the four FIR subsystems are used as the individual feature for signature verification. Finally, the signature can be verified by evaluating the difference between the impulse responses of the FIR subsystems for a reference signature and the signature to be verified. The signature verification experiments were performed on the SUBCORPUS-100 MCYT [J.Ortega-Garcia et al.2003] signature database consisting of 5,000 signatures from 100 signers. The propose method yielded equal error rate(EER) 4.38 % on skilled forgeries.
A New Integrated Hybrid Power Quality Control System for Electrical Railway (2015)

This paper presents an integrated hybrid railway power quality control system (HRPQC) to deal with the power quality problems in the electrical railway supply system. The prominent advantage of HRPQC is that, in the premise of adopting a hybrid compensating scheme for better performance, it can integrate the active system with the main transformer without other expensive low-frequency high-power auxiliary transformers. HRPQC's mathematical model, control idea, and transforming relationship in harmonic frequency are first presented. Second, the harmonic-suppressing mechanism and the resonance characteristics are analyzed in detail. Finally, simulation and experimental results verify the effectiveness of the proposed compensating system.
NMDA antagonists potentiate antiparkinsonian actions of <scp>L</scp>‐dopa in monoamine‐depleted rats (1990)

Systemically administered N-methyl-D-aspartate (NMDA) antagonists, MK-801 ((+)5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate) and CPP (3-[(+-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate), potentiate the ability of L-dopa (L-3,4-dihydroxyphenylalanine) to reverse akinesia and to alleviate muscular rigidity in monoamine-depleted rats. On the basis of these findings, it is proposed that NMDA antagonists may be beneficial as adjunctive treatment in the therapy of Parkinson's disease. CPP locally injected into the subthalamic nucleus, entopeduncular nucleus--the rat homologue of the internal pallidal segment--or substantia nigra pars reticulata of monoamine-depleted rats stimulates locomotor activity and alleviates rigidity, whereas local microinjection of CPP into the neostriatum is ineffective. These results make it unlikely that the neostriatum is the site of the antiparkinsonian action of NMDA antagonists in monoamine-depleted rats, whereas the subthalamic nucleus, internal pallidal segment, and substantia nigra pars reticulata appear to be important for the effects of NMDA antagonists.
Utility of Exposure‐Response Analysis in Regulatory Decision on the Selection of Starting Dose of Pasireotide for Cushing Disease (2015)

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Polarization of Strained AISI 4340 Steel in Oxygenated NaCl Solutions (1966)

Electrode reactions involved in the stress corrosion of AISI 4340 steel in sodium chloride solutions were studied by pulse galvanostatic and potentiostatic experiments. The redox cell system involves two principal cathodic reactions and one anodic reaction. These electrochemical reactions are affected by the application of stress, by change in pH, by oxygen content and the heat-treated condition of the materials. The effect of stress is to shift the cathodic polarization curve in an electropositive direction with increasing tensile load. It is equivalent to cathodic control for the conditions investigated and is described by the electrochemical interpretation, based on the coupling of the redox branches which produce the largest corrosion current.
Structure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapies (2013)

Protein-bound water molecules play key roles in structural features that can be targeted to gain high selectivity for either enzyme. The results of early phase clinical trials of checkpoint inhibitors have been mixed, but significant progress has been made in testing the combination of CHK1 inhibitors with genotoxic chemotherapy. Second-generation CHK1 inhibitors are likely to benefit from increased selectivity and oral bioavailability. While the optimum therapeutic context for CHK2 inhibition remains unclear, the emergence of single agent preclinical efficacy for CHK1 inhibitors in specific tumour types exhibiting constitutive replication stress represents exciting progress in exploring the therapeutic potential of these agents.
Genomic and Proteomic Profiling of Lung Cancers: Lung Cancer Classification in the Age of Targeted Therapy (2005)

Both proteomic and genomic methods offer promise for the classification of human lung carcinomas. This review summarizes the range of proteomic methods in development for lung cancer classification, and describes a number of recent analyses of messenger RNA expression in lung cancer. Multiple independent studies of mRNA expression profiles in lung adenocarcinoma have proven highly reproducible. Analyses of the relationship between expression profiles and tumor development and differentiation, the presence or absence of specific pathogenic mutations, patient prognosis and survival after surgical treatment, and specific histopathology all appear to be promising.