gebhart/patrepeval huggingface dataset:
Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist) (2020)

Neurofeedback has begun to attract the attention and scrutiny of the scientific and medical mainstream. Here, neurofeedback researchers present a consensus-derived checklist that aims to improve the reporting and experimental design standards in the field.
Lung Deposition after Electronically Breath-Controlled Inhalation and Manually Triggered Conventional Inhalation in Cystic Fibrosis Patients (2005)

The present work aimed to investigate whether lung deposition can be improved by using a device that optimizes the breathing pattern through electronic control. The relative lung deposition was estimated by inhalation of the marker substance, sodium cromoglycate (SCG), and measurement of urinary excretion of SCG. Thirteen cystic fibrosis (CF) patients (aged 8-20 years) received 20 mg of SCG as nebulizer solution by means of (a) conventional inhalation (Parimaster + Pari LC Star nebulizer, manual interrupter) and (b) electronically breath-controlled inhalation (AKITA + Pari LC Star nebulizer). Inhalations were trained and supervised by a physiotherapist. Patients were asked to provide answers to a questionnaire about the convenience of electronically breath-controlled inhalation. Urine was collected in five fractions until 12 h p.a., and the excreted SCG was determined by means of high-performance liquid chromatography (HPLC). Following breath-controlled inhalation, the amount of SCG excreted in urine was significantly greater than after conventional inhalation (2.22 +/- 0.61 mg vs. 1.63 +/- 0.59 mg, p < 0.001). The absorption half-life for SCG following breath-controlled inhalation was significantly shorter when compared with conventional inhalation (78 +/- 23 min vs. 107 +/- 29 min; p < 0.01), suggestive of a more peripheral deposition for the former. Ninety-two percent of the patients judged that the electronically breath-controlled inhalation was good or very good. In conclusion, inhalation with an electronically optimized breathing pattern yields a greater and more peripheral lung deposition of SCG compared with the manually triggered conventional nebulizer technique in CF patients with several years of aerosol inhalation experience.
Preparation and physical properties of LLDPE grafted with novel nonionic surfactants (2008)

Abstract Copolymers of linear low‐density polyethylene (LLDPE) grafted with two novel nonionic surfactants, acrylic glycerol monostearate ester (AGMS) and acrylic polyoxyethylenesorbitan monooleate ester (ATWEEN80), containing hydrophilic and hydrophobic groups and 1‐olefin double bond were prepared by using a plasticorder at 190°C. To evaluate the grafting degree, two different approaches based on 1 H‐NMR data were proposed, and FTIR calibration was showed to validate these methods. The rheological response of the molten polymers, determined under dynamic shear flow at small‐amplitude oscillations, indicated that crosslinking formation of the chains could be decreased with increasing the monomer concentration. Their thermal behavior was studied by DSC and polarization microscope (PLM): The crystallization temperature ( T C ) of grafted LLDPE shifted to higher temperature compared with neat LLDPE because the grafted chains acted as nucleating agents. Water and glycerol were used to calculate the surface free energy of grafted LLDPE films. The results indicated that the novel polyoxyethylene surfactant ATWEEN80 could greatly improve the hydrophilicity of LLDPE and the surface free energy varied from 33 mN/m of neat LLDPE to 106 mN/m of the grafted LLDPE film. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Engagement of the CrkL Adapter in Interleukin-5 Signaling in Eosinophils (2000)

Interleukin-5 (IL-5) drives the terminal differentiation of myeloid progenitors to the eosinophil lineage; blocks eosinophil apoptosis; and primes eosinophils for enhanced functional activities in allergic, parasitic, and other eosinophil-associated diseases. Here we describe a novel signaling pathway activated by the IL-5 receptor in eosinophils involving the CrkL adapter protein. We determined whether IL-5 induces activation of CrkL and STAT5 in eosinophils using both the human eosinophil-differentiated AML14.3D10 cell line and purified peripheral blood eosinophils from normal donors. Stimulation of AML14.3D10 cells or blood eosinophils with IL-5 induced rapid tyrosine phosphorylation of the CrkL adapter and STAT5 and the association of CrkL and STAT5 in vivo as evidenced by the detection of STAT5 in anti-CrkL immunoprecipitates. The resulting CrkL.STAT5 complexes translocated to the nucleus and bound STAT5 consensus DNA-binding sites present in the promoters of IL-5-regulated genes, as shown in gel mobility and antibody supershift assays. IL-5 also induced marked activity of an 8X-GAS (interferon gamma-activated site)-luciferase reporter construct in transient transfections of AML14.3D10 eosinophils, demonstrating that these complexes play a functional role in IL-5 signaling. CrkL was also found to interact, via its N-terminal SH3 domain, with C3G, a guanine exchange factor for the small G-protein Rap1, which was also rapidly activated in an IL-5-dependent manner in these cells, establishing that CrkL mediates downstream activation of at least two signaling cascades in IL-5-stimulated eosinophils. Thus, the CrkL adapter plays an important role in IL-5 signaling in the eosinophil, acting as a nuclear adapter for STAT5 and as an upstream regulator of the C3G-Rap1 signaling pathway.
Identification of a urine metabolite constellation characteristic for kidney allograft rejection (2018)

A metabolite constellation was defined with the potential for further development of an in-vitro diagnostic test that can support physicians in their clinical assessment of a kidney transplant patient.
Seamless boost converter control in critical boundary condition for fuel cell power conditioning system (2011)

The boost converter operates either in discontinuous conduction mode (DCM) or in continuous conduction mode (CCM). The operation mode is determined by the duty ratio, load and parameters of the boost converter. The plant model in DCM and CCM are different in the frequency domain response. Therefore, it will be difficult to design a controller with stable operation and fast transient response for both modes. Moreover, the boost converter will be unstable between DCM and CCM. In this paper, the proposed control strategy can transit between DCM and CCM seamlessly by adding a mode detector, the boost converter can be automatically operated by selecting of control loop in both operation modes. The proposed controller still has a voltage control loop in DCM and current/voltage control loops in CCM. Each controller is designed by considering the stability and response time. The proposed mode detector will be explained with a frequency domain analysis. Due to the wide range operation capability of the proposed control strategy, the proposed control strategy is suitable in the fuel cell portable applications. In addition, smooth operation of the converter will also be beneficial to the fuel cell stack reliability. A 20 W boost converter prototype is used to verify the performance of the proposed control scheme.
Note on the Computer as an Aid to the Architect (1966)

This paper is a description of a computer program written to evaluate the design of houses built from a pre-specified set of industrialized building components. This program was used as part of the display at the IBIS stand in the 1964 Industrialized Building Systems and Components Exhibition.
The First Synthesis of Bis(arylmethylidene)dioxan-5-ones: Potential Scaffolds to Access Vicinal Tricarbonyl Derivatives (2008)

Double crossed-aldol condensation of a variety of aromatic aldehydes with 1,3-dioxan-5-one in the presence of magnesium bromide diethyl etherate and diethylamine at room temperature is described. Excellent yields of 4,6-bis(arylmethylidene)dioxan-5-ones are achieved in a facile, one-pot, general procedure. The structure and the Z,Z-configuration of the exocyclic double bonds of the products were determined by spectroscopic methods and X-ray crystallography, respectively.
Reduction of three-phase transformer magnetizing inrush current by use of point on wave switching (2009)

At the time of transformer energization, a high current will be drawn by the transformer. The mentioned current is called transient inrush current and it may rise to ten times the nominal full load current of transformer during operation. Energization transients can produce mechanical stress to the transformer, causes protection system malfunction and it often affect the power system quality and may disrupt the operation of sensitive electrical loads such as computers and medical equipment connected to the system. Reduction and the way to control of energization transients currents have become important concerns to the power industry for engineers. One of the methods to reduce inrush current is use of point on wave switching at the time transformer is initially connected to supply. This paper discusses the simulations and the experimental results on a three-phase transformer for reduction of inrush currents. An electronic three-phase switching controller has been designed and some thyristors were used for switching power to the transformers.
I-Navigate: Intelligent, Self-adapting Navigation Maps (2007)

In the frame of our "I-Navigate" project, we create a software system that allows to extend digital navigation maps automatically and, thus, to improve their quality continuously. In order to achieve this, a track is gathered through tracing the paths of users (on foot, by car or by bicycle, for instance) via GPS. This track is converted into a route, which is merged with the current map graph and supplied to the user as an updated, navigable map. Areas of application comprise the continuous extension of car navigation systems (last mile integration), the addition of off-road features to navigation maps (e.g. for outdoor and leisure activities, like mountain biking or off-track skiing), but also the surveillance of users navigating such a track in order to enable better targeted rescues in emergency cases (e.g. for mountaineers)
Immunomodulation with anti-αβ T-cell receptor monoclonal antibodies in combination with cyclosporine a improves regeneration in nerve allografts (2006)

The immunomodulating protocol of combination anti-alpha/beta TCR mAbs and CsA for a 5 week period altered the rejection process, affording nerve regeneration. It may provide for an expanded source of nerve tissue to alleviate the morbidity of harvesting peripheral nerves from multiple sites for those afflicted with extensive peripheral nerve injuries.
Supervised and unsupervised web-based language model domain adaptation (2012)

Domain language model adaptation consists in re-estimating probabilities of a baseline LM in order to better match the specifics of a given broad topic of interest. To do so, a common strategy is to retrieve adaptation texts from the Web based on a given domain-representative seed text. In this paper, we study how the selection of this seed text influences the adaptation process and the performances of resulting adapted language models in automatic speech recognition. More precisely, the goal of this original study is to analyze the differences of our Web-based adaptation approach between the supervised case, in which the seed text is manually generated, and the unsupervised case, where the seed text is given by an automatic transcript. Experiments were carried out on data sourced from a real-world use case, more specifically, videos produced for a university YouTube channel. Results show that our approach is quite robust since the unsupervised adaptation provides similar performance to the supervised case in terms of the overall perplexity and word error rate.
UCSB final report for the CSQ program: Review of decoherence and materials physics for superconducting qubits (2014)

We review progress at UCSB on understanding the physics of decoherence in superconducting qubits. Although many decoherence mechanisms were studied and fixed in the last 5 years, the most important ones are two-level state defects in amorphous dielectrics, non-equilibrium quasiparticles generated from stray infrared light, and radiation to slotline modes. With improved design, the performance of integrated circuit transmons using the Xmon design are now close to world record performance: these devices have the advantage of retaining coherence when scaled up to 9 qubits.
Noninvasive Evaluation of Coronary Sinus Anatomy and Its Relation to the Mitral Valve Annulus (2007)

In the majority of the patients, the CS courses superiorly to the MVA. In 68% of the patients, the circumflex artery courses between the CS and the mitral annulus. Multislice computed tomography may provide useful information for the selection of potential candidates for percutaneous mitral annuloplasty.
NetMHCpan 4.0: Improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data (2017)

Abstract Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC (major histocompatibility complex) class I molecules. Peptide binding to MHC molecules is the single most selective step in the antigen presentation pathway. On the quest for T cell epitopes, the prediction of peptide binding to MHC molecules has therefore attracted large attention. In the past, predictors of peptide-MHC interaction have in most cases been trained on binding affinity data. Recently an increasing amount of MHC presented peptides identified by mass spectrometry has been published containing information about peptide processing steps in the presentation pathway and the length distribution of naturally presented peptides. Here, we present NetMHCpan-4.0, a method trained on both binding affinity and eluted ligand data leveraging the information from both data types. Large-scale benchmarking of the method demonstrates an increased predictive performance compared to state-of-the-art when it comes to identification of naturally processed ligands, cancer neoantigens, and T cell epitopes.
Nucleotides. Part XLVI. The synthesis of phospholipid conjugates of antivirally active nucleosides by the improved phosphoramidite methodology (1996)

Abstract The application of the improved phosphoramidite strategy for the synthese of oligonucleotides using β‐eliminating protecting groups to phospholipid chemistry offers the possibility to synthesize phospholipid conjugates of AZT ( 6 ) and cordycepin. The synthesis of 3′‐azido‐3′‐deoxythymidine ( 6 ) was achieved by a new isolation procedure without chromatographic purification steps in an overall yield of 50%. Protected cordycepin ( = 3′‐de‐oxyadenosine) derivatives, the N 6 ,2′‐bis[2‐(4‐nitrophenyl)ethoxycarbonyl]cordycepin ( 12 ) and the N 6 ,5′‐bis[2‐(4‐nitrophenyl)ethoxycarbonyl]cordycepin ( 13 ) wre prepared by known methods and direct acylation of N 6 ‐[2‐(4‐nitrophenyl)ethoxycarbonyl]cordycepin ( 9 ), respectively. These protected nucleosides and the 3′‐azido‐3′‐de‐oxythymidine ( 6 ) reacted with newly synthesized and properly characterized lipid‐phosphoramidites 21–25 , catalyzed by 1 H ‐tetrazole, to the corresponding nucleoside‐phospholipid conjugates 26–38 in high yield. The deprotection was accomplished via β‐elimination with 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) in aprotic solvents to give analytically pure nucleoside‐phospholipid diesters 39–51 as triethylammonium or sodium salts. The newly synthesized compounds were characterized by elemental analyses and UV and 1 H‐NMR spectra.
Isaac: ultra-fast whole-genome secondary analysis on Illumina sequencing platforms (2013)

Isaac has an open source license and can be obtained at https://github.com/sequencing.
Metonymy resolution as a classification task (2002)

We reformulate metonymy resolution as a classification task. This is motivated by the regularity of metonymic readings and makes general classification and word sense disambiguation methods available for metonymy resolution. We then present a case study for location names, presenting both a corpus of location names annotated for metonymy as well as experiments with a supervised classification algorithm on this corpus. We especially explore the contribution of features used in word sense disambiguation to metonymy resolution.
DRUG FIRMS REPORT MODERATE GROWTH (2003)

RETURN TO ISSUEPREVNewsNEXTDRUG FIRMS REPORT MODERATE GROWTHFirst-quarter 2003 brought sales gains for drugmakers, while earnings were mixedANN M. THAYERView Author Information C&EN HOUSTONCite this: Chem. Eng. News 2003, 81, 20, 23–24Publication Date (Print):May 19, 2003Publication History Published online13 November 2010Published inissue 19 May 2003https://doi.org/10.1021/cen-v081n020.p023Copyright © 2003 American Chemical SocietyArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) SUBJECTS:Pharmaceuticals Get e-Alerts
Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K) (2015)

A series of cardiac troponin I-interacting kinase (TNNI3K) inhibitors arising from 3-((9H-purin-6-yl)amino)-N-methyl-benzenesulfonamide (1) is disclosed along with fundamental structure-function relationships that delineate the role of each element of 1 for TNNI3K recognition. An X-ray structure of 1 bound to TNNI3K confirmed its Type I binding mode and is used to rationalize the structure-activity relationship and employed to design potent, selective, and orally bioavailable TNNI3K inhibitors. Identification of the 7-deazapurine heterocycle as a superior template (vs purine) and its elaboration by introduction of C4-benzenesulfonamide and C7- and C8-7-deazapurine substituents produced compounds with substantial improvements in potency (>1000-fold), general kinase selectivity (10-fold improvement), and pharmacokinetic properties (>10-fold increase in poDNAUC). Optimal members of the series have properties suitable for use in in vitro and in vivo experiments aimed at elucidating the role of TNNI3K in cardiac biology and serve as leads for developing novel heart failure medicines.
Effect of High-Pressure Inert Gas Annealing on AlON/Ge Gate Stacks (2012)

We investigated germanium (Ge) metal–insulator–semiconductor (MIS) gate stacks with aluminum oxynitride (AlON) thin dielectric film. We found that high-pressure inert gas post deposition annealing (PDA) using N2 or Ar gas dramatically improved the electrical properties of AlON/Ge MIS gate stacks. The advantage of this process over high-pressure O2 oxidation or annealing, which produce excellent Ge gate stacks, is that no further interface layer growth in the N2 or Ar PDA is expected. We expect that thin AlON films combined with high-pressure inert gas PDA will provide a new way to achieve excellent Ge-MIS gate stacks with scalable equivalent oxide thickness.
Antisense Regulation of Oncogenes in Human Cancer (1996)

Gene transfer or manipulation of genes for the treatment of cancer is a rapidly expanding field. In recent years, much attention has been focused on manipulating cancer genes and applying antisense technology in therapeutic ways. Consequently, antisense RNA control is now recognized as a specific means of regulating gene expression at the posttranscriptional level. Defects in vital genes occur in many human diseases, including cancer, defects that may be due to an accumulation of mutations in the genes that leads to the production of faulty proteins. Although the biological significance of such mutant proteins still remains in question, recent experiments have demonstrated that genes overproducing faulty proteins are often associated with increased tumor cell growth. Moreover, using a stretch of antisense RNA to block the production of such defective proteins can effectively silence their genes; as a result, tumor cells stop dividing rapidly and revert to a more normal phenotype. Therefore, antisense RNA technology could have a significant impact on cancer gene therapy. Here, we have tried to give comprehensive coverage to some major cases of antisense RNA control of cancer-related genes highlighting the biological systems involved, the efficacy of the antisense RNA in altering target gene function, and how such antisense control affects the malignant phenotype. Furthermore, the therapeutic potential of the antisense technique depends on the in-depth understanding of the target gene function and its role in carcinogenesis.
Resilience and service protection for ethernet passive optical networks in SIEPON (2012)

IEEE Ethernet passive optical networks support the SIEPON-defined data link protection for mission-critical services in a flexible, costeffective, and reliable manner, addressing the need for guaranteed link availability for mobile backhaul applications, business customers, institutions, data centers, campuses, and so on, serving hundreds or even thousands of subscribers. In this article, we look at the motivation behind the EPON protection schemes from a network operator perspective, as well as ways of delivering increased data service availability while minimizing the impact on the network cost and complexity. We also examine mechanisms used in EPON for link fault detection, spanning from physical through logical to link layers.