gebhart/patrepeval huggingface dataset:
Performance of an optical backplane bus for switch interconnection (1996)

The employment of an optical bus for the interconnection network of a switching system is investigated and the configuration of these interconnections is discussed. Using power budget analysis, it is shown that to maximise the number of positions for an amplified bus configuration, the number of taps between the amplifiers must be small, or amplification must be distributed within the bus. Crosstalk within cascaded bus arrays is examined and an ≈634 Gbits/s configuration of the MONET architecture is shown to be feasible.
Low-Temperature Monolithic Encapsulation Using Porous-Alumina Shell Anodized on Chip (2009)

A thin-film encapsulation process, featuring low-temperature steps, hermetic sealing (preliminary), and RF-compatible shell, is reported. Uniquely attractive as compared with the existing MEMS packaging approaches is its capability to monolithically package metal microstructures inside a microcavity on chip in one continuous surface-micromachining process. The key for this process is a technique to fabricate a large freestanding porous membrane on chip by postdeposition anodization of thin-film aluminum at room temperature. The porous-alumina membrane allows for the diffusion of gas or liquid etchants through the nanopores to etch away the sacrificial material underneath, freeing the movable microstructures encapsulated inside the cavity. To seal the package, a thin film is deposited over the alumina shell whose nanoscale pores of a high aspect ratio (> 30) do not allow any detectable penetration of the sealing material. The low-temperature (<300degC) encapsulation process produced a low-pressure seal (8 torr), monitored by a Pirani pressure gauge that also represents an encapsulated freestanding metal microstructure in the cavity. The thin-film package demonstrated a considerably low RF insertion loss of less than 0.1 dB up to 40 GHz.
Integration, Development and Performance of the 500 TFLOPS Heterogeneous Cluster (Condor) (2012)

The Air Force Research Laboratory Information Directorate Advanced Computing Division (AFRL/RIT) High Performance Computing Affiliated Resource Center (HPC-ARC) is the host to a very large scale interactive computing cluster consisting of about 1800 nodes. Condor, the largest interactive Cell cluster in the world, consists of integrated heterogeneous processors of IBM Cell Broadband Engine (Cell BE) multicore CPUs, NVIDIA General Purpose Graphic Processing Units (GPGPUs) and Intel x86 server nodes in a 10Gb Ethernet Star Hub network and 20Gb/s Infiniband Mesh, with a combined capability of 500 trillion floating operations per second (TFLOPS). Applications developed and running on CONDOR include large-scale computational intelligence models, video synthetic aperture radar (SAR) back-projection, Space Situational Awareness (SSA), video target tracking, linear algebra and others. This presentation will discuss the design and integration of the system. It will also show progress on performance optimization efforts and lessons learned on algorithm scalability on a heterogeneous architecture.
Beyond Antiangiogenesis: Vascular Modulation as an Anticancer Therapy—A Review (2012)

This review attempts to move beyond the traditional borders of antiangiogenesis and toward the dynamic, evolving strategies of vascular modulation. This repositioning entails a two-fold paradigm shift: conceptually, to a view of antiangiogenesis as only one part of a larger story, and therapeutically, to approaches which attempt to modulate tumor blood flow instead of simply inhibiting it. Three vascular modulation strategies-provascular, antivascular, and redistributive-are presented with representative compounds. These vascular modulation strategies are described in specific measurable characteristics (blood vessel maturity and type, effect on blood flow, microenvironmental target, molecular target, angiogenic biomarker, and imaging biomarkers) that will help define the tumor types that are more susceptible to a particular vascular modulation strategy thereby guiding therapeutic agent selection and enabling a personalized medicine approach.
MICROSTRUCTURE OF SOYBEAN PROTEIN AGGREGATES AND ITS RELATION TO THE PHYSICAL AND TEXTURAL PROPERTIES OF THE CURD (1978)

ABSTRACT The microstructure of soybean protein aggregates was examined by the optical microscope and the scanning electron microscope. The effects of heat and coagulating agents on the microstructure of the aggregates and on the physical and textural properties of the protein curd were investigated. Isoelectric point precipitation and calcium coagulation did not change the globular structure of the native soybean protein. However, heating induced the destruction of the native protein body. Heat denaturation of the protein was necessary in forming the network structure of the aggregates. When the protein aggregates were frozen, their structure became better defined and enlarged. The three dimensional network structure of the aggregate derived from heated soybean protein showed a low sedimentation rate, high curd yield, high water‐holding capacity, low value of hardness and high springiness compared to the unheated precipitates of globular structure.
High-Speed Binary-to-Decimal Conversion (1968)

Abstract—This note describes several methods of performing fast, efficient, binary-to-decimal conversion. With a modest amount of circuitry, an order of magnitude speed improvement is obtained. This achievement offers a unique advantage to general-purpose computers requiring special hardware to translate between binary and decimal numbering systems.
Solubilization of Regioregular and Regioirregular Poly(<i>p</i>-phenylene)s via CF<sub>3</sub> and OCF<sub>3</sub> Substituents To Generate a Model for Rigid-Rod Polymers (1996)

Regioirregular poly(p-phenylene)s (PPPs) with OCF3, CF3 or OCH3 substituents (16a, 16b, or 16c, respectively) were synthesized via Ni(0)-catalyzed polymerization of 2-substituted-1,4-bis[[(trifluoromethyl)sulfonyl]oxy]benzenes (5, 8, or 10, respectively). Regioregular head−to−head PPPs with OCF3 or CF3 substituents (17a or 17b) were prepared from 2,2‘-disubstituted-4,4‘-bis[[(trifluoromethyl)sulfonyl]oxy]biphenyls 14a, 14b and 2,2‘-disubstituted-4,4‘-bis[methylsulfonyl)oxy]biphenyls 15a, 15b. Regioregular head-to-head statistical copolymers with combinations of OCF3 or CF3 substituents with OCF3, CF3, CO(p-FC6H5), CH3, or H substituents (17xy) were synthesized by the copolymerization of 15a or 15b with 2,2‘-disubstituted-4,4‘-bis[(methylsulfonyl)oxy]biphenyls 15a−15e. Regioirregular and regioregular PPPs with OCF3 or CF3 substituents were soluble (THF, CHCl3, dipolar aprotic solvents). The highest molecular weight PPPs were obtained from OCF3-substituted monomers. Regioirregular PPP (16a) with Mn = 35 200 (corresponding to 220 phenylene groups relative to polystyrene standards) was obtained from 5. Regioregular PPP (17a) with Mn = 54 500 (340 phenylene units) was obtained from 14a. Regioregular PPP copolymers (17ab) with Mn = 55 200 (363 phenylene units) were obtained from copolymerization of 15a and 15b. The λmax values of OCF3- and CF3-substituted PPPs were 302−307 and 273−271, respectively. A 10% weight loss occurs in the range of 550−575 °C for PPPs with OCF3 substituents and 580−615 °C for those with CF3 substituents. Polymers 17a, 17b, and 17ab exhibit enantiotropic nematic and lyotropic mesophases. The thermotropic nematic phase of 17a, 17b, and 17ab is stable up to the decomposition temperature. Most probably, 17a and 17b also exhibit a second mesophase which is monotropic and becomes enantiotropic in 17ab. The rigid-rod character of these polymers was demonstrated by the Mark−Houwink coefficient a = 1.58−1.60. Phosphorus was not detected (MALDI and 31P NMR) in the structure of these homopolymers and copolymers.
A chimeric MIP-1alpha/RANTES protein demonstrates the use of different regions of the RANTES protein to bind and activate its receptors. (2001)

Human RANTES (CCL5) and MIP-1alpha (CCL3) bind and activate several CC chemokine receptors. RANTES is a high-affinity ligand for CCR1 and CCR5, and it binds CCR3 with moderate affinity and CCR4 with low affinity. MIP-1alpha has similar binding characteristics to RANTES except that it does not bind to CCR3. Here we have generated a chimera of human MIP-1alpha and RANTES, called MIP/RANTES, consisting of the eight amino terminal residues of MIP-1alpha preceding the CC motif, and the remainder of the sequence is RANTES. The chimera is able to induce chemotaxis of human monocytes. MIP/RANTES has >100-fold reduction in binding to CCR1 and does not bind to CCR3 but retains full, functional binding to CCR5. It has equivalent affinity for CCR5 to MIP-1alpha and RANTES, binding with an IC(50) of 1.12 nM, and is able to mobilize calcium and induce endocytosis of CCR5 in PBMC in a manner equi-potent to RANTES. It also retains the ability to inhibit R5 using HIV-1 strains. Therefore, we conclude that the amino terminus of RANTES is not involved in CCR5 binding, but it is essential for CCR1 and CCR3.
In vitro studies on the effect of spleen, striated muscle, and kidney upon the growth of sarcoma 180 and mammary carcinoma of mice. (1949)

Summary 1.Mouse sarcoma 180 and spontaneous adenocarcinoma of the mouse mammary gland were grown in tissue culture with homologous spleen, skeletal muscle, and kidney from nontumor-bearing animals. 2.No tumor-growth effect was detected when such series were compared with tumor explants grown alone in tissue culture. 3.After tissue culture with spleen, skeletal muscle, and kideney, explants of sarcoma 180 produced malignant growths in mouse hosts histologically similar to control biopsies. The time of appearance and growth characteristics of these tumors did not differ from neoplasms appearing in control animals inoculated with tumor explants grown in tissue culture alone.
Confirmation of a de novo structure prediction for an atomically precise monolayer-coated silver nanoparticle (2016)

Fathoming the principles underpinning the structures of monolayer-coated molecular metal nanoparticles remains an enduring challenge. Notwithstanding recent x-ray determinations, coveted veritable de novo structural predictions are scarce. Building on recent syntheses and de novo structure predictions of <i>M</i><sub>3</sub>Au <sub><i>x</i></sub> Ag<sub>17-<i>x</i></sub> (TBBT)<sub>12</sub>, where <i>M</i> is a countercation, <i>x</i> = 0 or 1, and TBBT is 4-<i>tert</i>-butylbenzenethiol, we report an x-ray-determined structure that authenticates an a priori prediction and, in conjunction with first-principles theoretical analysis, lends force to the underlying forecasting methodology. The predicted and verified Ag(S<i>R</i>)<sub>3</sub> monomer, together with the recently discovered Ag<sub>2</sub>(S<i>R</i>)<sub>5</sub> dimer and Ag<sub>3</sub>(S<i>R</i>)<sub>6</sub> trimer, establishes a family of unique mount motifs for silver thiolate nanoparticles, expanding knowledge beyond the earlier-known Au-S staples in thiol-capped gold nanoclusters. These findings demonstrate key principles underlying ligand-shell anchoring to the metal core, as well as unique T-like benzene dimer and cyclic benzene trimer ligand bundling configurations, opening vistas for rational design of metal and alloy nanoparticles.
High-Level Production of Heterologous Protein by Engineered Yeasts Grown in Cottage Cheese Whey (1999)

Cottage cheese whey is a cheese industry by-product still rich in proteins and lactose. Its recycling is seldom cost-effective. In this work we show that the lactose-utilizing yeast Kluyveromyces lactis, engineered for production of recombinant human lysozyme, can be grown in cottage cheese whey, resulting in high-level production of the heterologous protein (125 microg/ml).
Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum (1989)

A cDNA clone encoding the high affinity Ca2+-binding protein (HACBP) of rabbit skeletal muscle sarcoplasmic reticulum was isolated and sequenced. The cDNA encoded a protein of 418 amino acids, but a comparison of the deduced amino acid sequence with the NH2-terminal amino acid sequence of the purified protein indicates that a 17-residue NH2-terminal signal sequence was removed during synthesis. This was confirmed by studies of in vitro translation of mRNA encoding the protein. Structural predictions did not reveal any potential transmembrane segments in the protein. The COOH-terminal sequence of the high affinity Ca2+-binding protein, Lys-Asp-Glu-Leu, is the same as that proposed to be an endoplasmic reticulum retention signal (Munro, S., and Pelham, H. R. B. (1987) Cell 48, 899-907). All of these characteristics suggest that the protein is localized in the lumen of the sarcoplasmic reticulum. The mature protein of Mr 46,567 contains 109 acidic and 52 basic amino acids. Structural predictions suggest that the first half of the molecule forms a globular domain of 8 anti-parallel beta-strands with a helix-turn-helix motif at the extreme NH2 terminus. The next one-third of the sequence is proline-rich. This segment can be subdivided into a charged region which contains a 17-amino acid repeat, followed by a proline, serine, and threonine-rich segment extending from Pro-246 to Thr-316. Thirty-seven acidic residues are clustered within 56 amino acids at the COOH terminus of the protein. Although the protein binds 1 mol of Ca2+/mol with high affinity, no "EF-hand" consensus sequence was observed in the protein. The acidic COOH terminus, however, could account for the low affinity, high capacity Ca2+ binding observed in the protein. In agreement with other involved laboratories, we have chosen the name calreticulin for the protein.
Time-Division Multiplex in Radiotelegraphic Practice (1938)

The paper outlines certain methods of multiplexing telegraphic signals on a common communication channel and the factors governing the application of these methods to radio circuits. The recently developed trend toward the use of multiplex methods in radiotelegraphic service is discussed. Consideration is given to the advantages of using the time division method based on the baud, at least at the present state of the radio art. General specifications for the equipment are stated, based on practical operating requirements. Major changes from practices obtaining on wire-line multiplex systems are mentioned and the reasons therefor are given. A description of a practical system based on the above considerations and its use and effectiveness in a large radiotelegraph organization is furnished.
Kalman Filter-Based Integration of DGPS and Vehicle Sensors for Localization (2007)

We present a position estimation scheme for cars based on the integration of global positioning system (GPS) with vehicle sensors. The aim is to achieve enough accuracy to enable in vehicle cooperative collision warning, i.e., systems that provides warnings to drivers based on information about the motions of neighboring vehicles obtained by wireless communications from those vehicles, without use of ranging sensors. The vehicle sensors consist of wheel speed sensors, steering angle encoder, and a fiber optic gyro. We fuse these in an extended Kalman filter. The process model is a dynamic bicycle model. We present data from about 60 km of driving in urban environments including stops, intersection turns, U-turns, and lane changes, at both low and high speeds. The data show the filter estimates position, speed, and heading with the accuracies required by cooperative collision warning in all except two kinds of settings. The data also shows GPS and vehicle sensor integration through a bicycle model compares favorably with position estimation by fusing GPS and inertial navigation system (INS) through a kinematic model.
Microflex: a new technique for hybrid integration for microsystems (2002)

This paper describes a new interconnection wire method which allows versatile multiple strand connections between microsensors: sensor arrays and integrated circuits (IC). The interconnection method is termed Micro Flex Interconnects (MFI). One example for this technology is the connection of implantable, highly flexible neural micro devices to electronics for interfacing to the external world. The interconnection technique is based on a novel multilayer process using polyimide (Du Pont PI 2611). The thickness of the polyimide structure ranges from 5 to 15 /spl mu/m including the insulation layers. Several metallization layers can be embedded in the material. This approach exhibits same advantages. The involved material is non-toxic and the ICs do not need any additional bond pad metallization. The MFI technique has been proven long-term stable. The metallization material can be chosen accordingly for electrodes, conducting lines, and connection pads. An commercial ball wedge bonder is the only equipment needed to perform the MFI method.
Effect of Annealing Temperature on the Crystallographic and Optical Properties of ZnO Films (2022)

تم تحضير أغشية ZnO Polycrystalline على ركيزة زجاجية عن طريق تبخير المذيب عند 25 درجة مئوية ، ولدين بعد ذلك في الهواء عند درجات حرارة التلدين (100 ، 200 ، 300 درجة مئوية) لمدة ساعة واحدة. تم تمييز العينات
New strategies for cancer immunotherapy: targeting regulatory T cells (2017)

The immunosuppressive action of regulatory T (Treg) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating Treg cells and expression of specific molecules, suggesting novel strategies to overcome resistance to cancer immunotherapy.
The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold (2002)

We have determined the solution structure of ribosomal protein L18 from Thermus thermophilus. L18 is a 12.5 kDa protein of the large subunit of the ribosome and binds to both 5 S and 23 S rRNA. In the uncomplexed state L18 folds to a mixed alpha/beta globular structure with a long disordered N-terminal region. We compared our high-resolution structure with RNA-complexed L18 from Haloarcula marismortui and T. thermophilus to examine RNA-induced as well as species-dependent structural differences. We also identified T. thermophilus S11 as a structural homologue and found that the structures of the RNA-recognition sites are conserved. Important features, for instance a bulge in the RNA-contacting beta-sheet, are conserved in both proteins. We suggest that the L18 fold recognizes a specific RNA motif and that the resulting RNA-protein-recognition module is tolerant to variations in sequence.
Regeneration of zinc anodes for the Electric Fuel(R) zinc-air refuelable EV battery system (1997)

The Electric Fuel Limited (EFL) refuelable zinc-air battery system is currently being tested in a number of electric vehicle demonstration projects, the largest of which is a field test of zinc-air postal vans sponsored chiefly by Deutsche Post AG (the German Post Office). The zinc-air battery is not recharged electrically, but rather is 'refueled' through a series of mechanical and electrochemical steps that will require a special infrastructure in commercial application. As part of the German Post Office field test program, Electric Fuel designed and constructed a pilot zinc anode regeneration plant in Bremen, Germany. This plant is capable of servicing up to 100 commercial vans per week, which is adequate for the field test vehicle fleet. This paper describes the design and operation of each of the areas and devices within the plant.
LAYERED CERAMICS: Processing and Mechanical Behavior (1997)

▪ Abstract Recent progress in the field of mechanical behavior of layered ceramics is reviewed. Several processing techniques are described with reference to the fabrication of ceramic laminates. These include tape-casting, centrifugal casting, slip-casting, electrophoretic deposition (EPD), and the production of fibrous monolith materials. The review discusses various laminar design approaches for achieving improvements in strength, toughness, work of fracture, R-Curve behavior, and contact damage resistance. Examples of effective strategies include manipulation of residual stresses, the incorporation of weak interlayers to induce crack deflection, and promotion of synergistic effects between layer materials that exhibit intrinsically different responses.
Size Distribution for Crystallization with Continuous Growth and Breakage (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSize Distribution for Crystallization with Continuous Growth and BreakageThomas J. Fitzgerald and Tai-cheng YangCite this: Ind. Eng. Chem. Fundamen. 1972, 11, 4, 588–590Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://doi.org/10.1021/i160044a028RIGHTS & PERMISSIONSArticle Views107Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (327 KB) Get e-Alerts
Using performance reflection in systems software (2003)

Permission is granted for noncommercial reproduction of the work for educational or research purposes.
Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr (2001)

In a longitudinal study of the effects of moderate (70%) dietary restriction (DR) on aging, plasma glucose and insulin concentrations were measured from semiannual, frequently sampled intravenous glucose tolerance tests (FSIGTT) in 30 adult male rhesus monkeys. FSIGTT data were analyzed with Bergman's minimal model, and analysis of covariance revealed that restricted (R) monkeys exhibited increased insulin sensitivity (S(I), P < 0.001) and plasma glucose disappearance rate (K(G), P = 0.015), and reduced fasting plasma insulin (I(b), P < 0.001) and insulin response to glucose (AIR(G), P = 0.023) compared with control (C; ad libitum-fed) monkeys. DR reduced the baseline fasting hyperinsulinemia of two R monkeys, whereas four C monkeys have maintained from baseline, or subsequently developed, fasting hyperinsulinemia; one has progressed to diabetes. Compared with only the normoinsulinemic C monkeys, R monkeys exhibited similarly improved FSIGTT and minimal-model parameters. Thus chronic DR not only has protected against the development of insulin resistance in aging rhesus monkeys, but has also improved glucoregulatory parameters compared with those of otherwise normoinsulinemic monkeys.
Elastomeric Fibers Based on Polyurethanes (1962)

Abstract Highly elastic polyurethanes suitable for fiber production can be obtained by various synthetic routes based on diisocyanate polyaddition processes. Macrodiisocyanates obtained from long chain diols and diisocyanates are allowed to react with polyamines during fiber formation (chemical spinning process) or the macrodiisocyanates are treated in solvents (e.g. dimethylformamide) with polyamines to give highly viscous, spinnable solutions of polymer. Both methods yield highly elastic polymers with wide‐mesh network structures. The production of polyurethane fibers and their structures and physical properties are described.