gebhart/patrepeval huggingface dataset:
Schemes of dynamic redundancy for fault tolerance in random access memories (1988)

For large memory capacities, stand-by systems usually need a considerable amount of redundant hardware, not only because of the spare components, but for storing fault conditions and for carrying out the necessary reconfiguration. As alternatives, two methods of implementing fault tolerance by means of dynamic redundancy in random-access memories are proposed which allow the treatment of memory-chip faults at the interface of the memory. The memory reliability for both approaches is estimated by a simple model. These methods improve the reliability considerably compared to conventional memory fault tolerance methods, and the size of the units of reconfiguration can be tailored to the demands of the system user.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermochromic VO<sub>2</sub> Thin Films: Solution-Based Processing, Improved Optical Properties, and Lowered Phase Transformation Temperature (2010)

This paper describes a solution-phase synthesis of high-quality vanadium dioxide thermochromic thin films. The films obtained showed excellent visible transparency and a large change in transmittance at near-infrared (NIR) wavelengths before and after the metal-insulator phase transition (MIPT). For a 59 nm thick single-layer VO(2) thin film, the integral values of visible transmittance (T(int)) for metallic (M) and semiconductive (S) states were 54.1% and 49.1%, respectively, while the NIR switching efficiencies (DeltaT) were as high as 50% at 2000 nm. Thinner films can provide much higher transmittance of visible light, but they suffer from an attenuation of the switching efficiency in the near-infrared region. By varying the film thickness, ultrahigh T(int) values of 75.2% and 75.7% for the M and S states, respectively, were obtained, while the DeltaT at 2000 nm remained high. These results represent the best data for VO(2) to date. Thicker films in an optimized range can give enhanced NIR switching efficiencies and excellent NIR blocking abilities; in a particularly impressive experiment, one film provided near-zero NIR transmittance in the switched state. The thickness-dependent performance suggests that VO(2) will be of great use in the objective-specific applications. The reflectance and emissivity at the wavelength range of 2.5-25 microm before and after the MIPT were dependent on the film thickness; large contrasts were observed for relatively thick films. This work also showed that the MIPT temperature can be reduced simply by selecting the annealing temperature that induces local nonstoichiometry; a MIPT temperature as low as 42.7 degrees C was obtained by annealing the film at 440 degrees C. These properties (the high visible transmittance, the large change in infrared transmittance, and the near room-temperature MIPT) suggest that the current method is a landmark in the development of this interesting material toward applications in energy-saving smart windows.
Brief Report—Human Embryonic Stem Cell-Derived Mesenchymal Progenitors Possess Strong Immunosuppressive Effects Toward Natural Killer Cells as Well as T Lymphocytes (2008)

The derivation of mesenchymal progenitors from human embryonic stem cells (hESCs) has recently been reported. We studied the immune characteristics of these hESC-derived mesenchymal progenitors (EMPs) and their interactions with T lymphocytes and natural killer cells (NKs), two populations of lymphocytes with important roles in transplantation immunology. EMPs express a number of bone marrow mesenchymal stromal cell (BMMSC) markers, as well as the hESC marker SSEA-4. Immunologically, EMPs do not express HLA-DR or costimulatory molecules. On the other hand, HLA-G, a nonclassic MHC I protein involved in mediating maternal-fetal tolerance, can be found on the surface of EMPs, and its expression is increased after interferon-gamma stimulation. EMPs can suppress CD4(+) or CD8(+) lymphocyte proliferation, similar to BMMSCs. However, EMPs are more resistant to NK-mediated lysis than BMMSCs and can suppress the cytotoxic effects of activated NKs, as well as downregulating the NK-activating receptors NKp30 and NKp46. With their broad immunosuppressive properties, EMPs may represent a new potential cell source for therapeutic use.
Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. (1985)

We examined the effect of double-strand breaks on homologous recombination between two plasmids in human cells and in nuclear extracts prepared from human and rodent cells. Two pSV2neo plasmids containing nonreverting, nonoverlapping deletions were cotransfected into cells or incubated with cell extracts. Generation of intact neo genes was monitored by the ability of the DNA to confer G418r to cells or Neor to bacteria. We show that double-strand breaks at the sites of the deletions enhanced recombination frequency, whereas breaks outside the neo gene had no effect. Examination of the plasmids obtained from experiments involving the cell extracts revealed that gene conversion events play an important role in the generation of plasmids containing intact neo genes. Studies with plasmids carrying multiple polymorphic genetic markers revealed that markers located within 1,000 base pairs could be readily coconverted. The frequency of coconversion decreased with increasing distance between the markers. The plasmids we constructed along with the in vitro system should permit a detailed analysis of homologous recombinational events mediated by mammalian enzymes.
INFERENCES ABOUT QUANTITATIVE INHERITANCE BASED ON NATURAL POPULATION STRUCTURE IN THE YELLOW MONKEYFLOWER,<i>MIMULUS GUTTATUS</i> (1996)

We used a nonmanipulative, marker-based method to study quantitative genetic inheritance in two habitats of a common monkeyflower population. The method involved regressing quantitative trait similarity on marker-estimated relatedness between individuals sampled in the field. We sampled 300 adult plants from each of two transects, one along a stream habitat and another through a meadow habitat. For each plant we measured 10 quantitative characters and assayed 10 polymorphic isozyme loci. In the meadow habitat, relatedness of plants within 1 m was moderate (r = 0.125, corresponding to half-sibs) as was actual variance of relatedness (V<sub>r</sub> = 0.044). Significant heritabilities of 50-70% were found for corolla width and the fitness characters of flower number and plant weight. Genetic correlations were strongly positive, but sharing of environmental effects within 1 m was weak. In the stream habitat, levels of relatedness were lower and similar heritabilities were indicated. To detect dominance variance and the correlation of phenotypes due to shared inbreeding, we also estimated higher-order coefficients of relationship and inbreeding, but these did not significantly differ from zero. Laboratory-based estimates of heritability in the field were lower than the marker-based estimates, indicating that natural heritabilities and genetic correlations may be stronger than indicated by controlled studies.
Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2) (2009)

Tumor necrosis factor (TNF) elicits its biological activities by stimulation of two receptors, TNFR1 and TNFR2, both belonging to the TNF receptor superfamily. Whereas TNFR1-mediated signal transduction has been intensively studied and is understood in detail, especially with respect to activation of the classical NFkappaB pathway, cell death induction, and MAP kinase signaling, TNFR2-associated signal transduction is poorly defined. Here, we demonstrate in various tumor cell lines and primary T-cells that TNFR2, but not TNFR1, induces activation of the alternative NFkappaB pathway. In accord with earlier findings demonstrating that only membrane TNF, but not soluble TNF, properly activates TNFR2, we further show by use of TNFR1- and TNFR2-specific mutants of soluble TNF and membrane TNF that soluble ligand trimers fail to activate the alternative NFkappaB pathway. In accord with the known inhibitory role of TRAF2 in the alternative NFkappaB pathway, TNFR2-, but not TNFR1-specific TNF induced depletion of cytosolic TRAF2. Thus, we identified activation of the alternative NFkappaB pathway as a TNF signaling effect that can be specifically assigned to TNFR2 and membrane TNF.
Enhancing loudspeaker-based 3D audio with room modeling (2010)

For many years, spatial (3D) sound using headphones has been widely used in a number of applications. A rich spatial sensation is obtained by using head related transfer functions (HRTF) and playing the appropriate sound through headphones. In theory, loudspeaker audio systems would be capable of rendering 3D sound fields almost as rich as headphones, as long as the room impulse responses (RIRs) between the loudspeakers and the ears are known. In practice, however, obtaining these RIRs is hard, and the performance of loudspeaker based systems is far from perfect. New hope has been recently raised by a system that tracks the user's head position and orientation, and incorporates them into the RIRs estimates in real time. That system made two simplifying assumptions: it used generic HRTFs, and it ignored room reverberation. In this paper we tackle the second problem: we incorporate a room reverberation estimate into the RIRs. Note that this is a nontrivial task: RIRs vary significantly with the listener's positions, and even if one could measure them at a few points, they are notoriously hard to interpolate. Instead, we take an indirect approach: we model the room, and from that model we obtain an estimate of the main reflections. Position and characteristics of walls do not vary with the users' movement, yet they allow to quickly compute an estimate of the RIR for each new user position. Of course the key question is whether the estimates are good enough. We show an improvement in localization perception of up to 32% (i.e., reducing average error from 23.5° to 15.9°).
Development of SiAlON materials (1977)

Cold pressing and sintering techniques were used to produce ceramic bodies in which the major phase was beta prime Si3-Al-O-N4 solid solution. A variety of foreign oxides were used to promote liquid phase sintering, and this resulted in the incorporation of additional solid phases in the ceramic bodies which controlled elevated temperature properties. None of the bodies studied to date exhibited both adequate high temperature mechanical properties and oxidation resistance. Criteria are suggested to guide the formulation of bodies with improved high temperature properties.
Enhancing Data Processing on Clouds with Hadoop/HBase (2011)

In the current information age, large amounts of data are being generated and accumulated rapidly in various industrial and scientific domains. This imposes important demands on data processing capabilities that can extract sensible and valuable information from the large amount of data in a timely manner. Hadoop, the open source implementation of Google's data processing framework (MapReduce, Google File System and BigTable), is becoming increasingly popular and being used to solve data processing problems in various application scenarios. However, being originally designed for handling very large data sets that can be divided easily in parts to be processed independently with limited inter-task communication, Hadoop lacks applicability to a wider usage case. As a result, many projects are under way to enhance Hadoop for different application needs, such as data warehouse applications, machine learning and data mining applications, etc. This thesis is one such research effort in this direction. The goal of the thesis research is to design novel tools and techniques to extend and enhance the large-scale data processing capability of Hadoop/HBase on clouds, and to evaluate their effectiveness in performance tests on prototype implementations. Two main research contributions are described. The first contribution is a light-weight computational workflow system called "CloudWF" for Hadoop. The second contribution is a client library called "HBaseSI" supporting transactional snapshot isolation (SI) in HBase, Hadoop's database component.\n\nCloudWF addresses the problem of automating the execution of scientific workflows composed of both MapReduce and legacy applications on clouds with Hadoop/HBase. CloudWF is the first computational workflow system built directly using Hadoop/HBase. It uses novel methods in handling workflow directed acyclic graph decomposition, storing and querying dependencies in HBase sparse tables, transparent file staging, and decentralized workflow execution management relying on the MapReduce framework for task scheduling and fault tolerance.\n\nHBaseSI addresses the problem of maintaining strong transactional data consistency in HBase tables. This is the first SI mechanism developed for HBase. HBaseSI uses novel methods in handling distributed transactional management autonomously by individual clients. These methods greatly simplify the design of HBaseSI and can be generalized to other column-oriented stores with similar architecture as HBase. As a result of the simplicity in design, HBaseSI adds low overhead to HBase performance and directly inherits many desirable properties of HBase. HBaseSI is non-intrusive to existing HBase installations and user data, and is designed to work with a large cloud in terms of data size and the number of nodes in the cloud.
DPA-substituted coumarins as chemosensors for zinc(<scp>ii</scp>): modulation of the chemosensory characteristics by variation of the position of the chelate on the coumarin (2004)

The sensory capabilities of two novel di(2-picolyl)amine (DPA)-substituted coumarins are described and it is shown that the variation of the point of attachment of the DPA group to the coumarin framework controls their sensing behavior: the 4-substituted system is a CHEF-type sensor that shows a significant increase in fluorescence intensity upon Zn(2+) binding, whereas the 3-substituted system is a ratiometric sensor.
Efficient reversal of phiC31 integrase recombination in mammalian cells (2012)

Over the past decade, the integrase enzyme from phage phiC31 has proven to be a useful genome engineering tool in a wide variety of species, including mammalian cells. The enzyme efficiently mediates recombination between two distinct sequences, attP and attB, producing recombinant product sites, attL and attR. The reaction proceeds exclusively in a unidirectional manner, because integrase is unable to synapse attL and attR. To date, use of phiC31 integrase has been limited to attP × attB recombination. The factor needed for the reverse reaction--the excisionase or recombination directionality factor (RDF)--was identified recently and shown to function in vitro and in bacterial cells. To determine whether the phiC31 RDF could also function in mammalian cells, we cloned and tested several vectors that permit assessment of phiC31 RDF activity in mammalian environments. In the human and mouse cell lines tested (HeLa, HEK293, and NIH3T3), we observed robust RDF activity, using plasmid and/or genomic assays. This work is the first to demonstrate attL-attR serine integrase activity in mammalian cells and validates phiC31 RDF as a new tool that will enable future studies to take advantage of phiC31 integrase recombination in the forward or reverse direction.
Low-temperature growth of ZnSe by molecular beam epitaxy using cracked selenium (1990)

Growth of high quality ZnSe films has been achieved at growth temperatures as low as 150 °C by using elemental zinc and thermally cracked selenium as source materials. Crystallinity of the films was determined by the Zn/Se flux ratio rather than by the growth rate; it was possible to grow good crystalline films at growth rates from 0.5 to 1 μm/h. Photoluminescence and x-ray measurements indicated that there is little degradation in the film quality as the growth temperature is lowered from 350 to 150 °C.
Synthesis of<i>N</i>-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications (2013)

Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonist [3H] quinuclidinyl benzilate in radioligand muscarinic binding assays (3H-QNB) in bioassays. One of the heterocyclic salts, compound 7, met the significance criteria in these assays (>50% inhibition) at 10 μM of the nonselective muscarinic antagonist (3H-QNB) in cells of the Wistar rat cerebral cortex. Furthermore, this compound displayed 61% inhibition at 10 μM of the antagonist (3H-QNB) for the M5 receptor (IC50 6.34 μM, Ki 3.93 μM, nH = 0.996) in human recombinant CHO cell lines. These data obtained from Ricerca Biosciences suggested that compound 7 was selective for the M5 receptor. Another study from the Czech Academy of Sciences demonstrated that compound 7 was 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition with antagonist N-methylscopolamine and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol.
Energy-based adaptive compression in water network control systems (2016)

Contemporary water distribution networks exploit Internet of Things (IoT) technologies to monitor and control the behavior of water network assets. Smart meters/sensor and actuator nodes have been used to transfer information from the water network to data centers for further analysis. Due to the underground position of water assets, many water companies tend to deploy battery driven nodes which last beyond the 10-year mark. This prohibits the use of high-sample rate sensing therefore limiting the knowledge we can obtain from the recorder data. To alleviate this problem, efficient data compression enables high-rate sampling, whilst reducing significantly the required storage and bandwidth resources without sacrificing the meaningful information content. This paper introduces a novel algorithm which combines the accuracy of standard lossless compression with the efficiency of a compressive sensing framework. Our method balances the tradeoffs of each technique and optimally selects the best compression mode by minimizing reconstruction errors, given the sensor node battery state. To evaluate our algorithm, real high-sample rate water pressure data of over 170 days and 25 sensor nodes of our real world large scale testbed was used. The experimental results reveal that our algorithm can reduce communication around 66% and extend battery life by 46% compared to traditional periodic communication techniques.
Flt23k Nanoparticles Offer Additive Benefit in Graft Survival and Anti-Angiogenic Effects When Combined with Triamcinolone (2012)

Anti-VEGF nanoparticles (Flt23k) have a significant effect on decreasing neovascularization and lymphangiogenesis, resulting in increased graft survival in penetrating keratoplasty. This beneficial effect is synergistically enhanced with steroid treatment.
Molecular Behavior of Flufenamic Acid in Physical and Ground Mixtures with Florite. (1992)

The molecular behavior of flufenamic acid (FFA) was investigated in the physical and ground mixtures with two types of florite, florite R (FR) and florite S (FS). FR is mainly composed of porous calcium silicate while the main component of FS is porous silicon dioxide. The interaction of FFA and nonporous calcium silicate was also studied. Analyses were performed by differential scanning calorimetry, powder X-ray diffraction, and infrared-spectroscopy. Storage and grinding of the mixtures of FFA and FR resulted in the transformation of FFA to the amorphous ionic state, predominantly to calcium salt, and the amorphous state of the drug was found to be more stable in mixtures of higher FR content. In the mixture of FFA and FS, longer storage or grinding was necessary to obtain the amorphous state of FFA, and no change in its chemical state was observed. Differences of the FFA molecular state in the mixtures with FR and FS were attributed to differences of the chemical composition of these additives. Nonporous calcium silicate was found to have limited ability to induce transformation of FFA to the amorphous state as it has small surface area and lacks a porous structure. Stored or ground mixtures of FFA and FR showed marked enhancement in the dissolution behavior of FFA due to the existence of FFA in the amorphous ionic form.
An Anti-phishing User Authentication Scheme without Using a Sensitive Key Table (2011)

Phishing is a popular technique that attackers use for the obtainment of sensitive information about users. Last year, over 44 million users became victims of phishing websites. Mutual authentication between user and server is an essential part of anti-phishing mechanisms. Lee et al. proposed a scheme that achieves mutual authentication to protect users from phishing attacks. However, a sensitive key table is necessary if users want to achieve mutual authentication on different servers. This attracts attackers' attention and increases the cost of maintaining the key. In this paper, a novel anti-phishing authentication scheme without a sensitive key table is presented. No sensitive key table is needed if the user is present at that time. Moreover, the proposed scheme can prevent guessing and replay attacks, which are serious threats to user authentication.
Service placement in a shared wide-area platform (2006)

Emerging federated computing environments offer attractive platforms to test and deploy global-scale distributed applications. When nodes in these platforms are timeshared among competing applications, available resources vary across nodes and over time. Thus, one open architectural question in such systems is how to map applications to available nodes--that is, how to discover and select resources. Using a six-month trace of PlanetLab resource utilization data and of resource demands from three long-running PlanetLab services, we quantitatively characterize resource availability and application usage behavior across nodes and over time, and investigate the potential to mitigate the application impact of resource variability through intelligent service placement and migration.

We find that usage of CPU and network resources is heavy and highly variable. We argue that this variability calls for intelligently mapping applications to available nodes. Further, we find that node placement decisions can become ill-suited after about 30 minutes, suggesting that some applications can benefit from migration at that timescale, and that placement and migration decisions can be safely based on data collected at roughly that timescale. We find that inter-node latency is stable and is a good predictor of available bandwidth; this observation argues for collecting latency data at relatively coarse timescales and bandwidth data at even coarser timescales, using the former to predict the latter between measurements. Finally, we find that although the utilization of a particular resource on a particular node is a good predictor of that node's utilization of that resource in the near future, there do not exist correlations to support predicting one resource's availability based on availability of other resources on the same node at the same time, on availability of the same resource on other nodes at the same site, or on time-series forecasts that assume a daily or weekly regression to the mean.