gebhart/patrepeval huggingface dataset:
Mobile kits and laptop trays (2007)

A study at a large IT company shows that mobile information workers frequently migrate work across devices (here: smartphones, desktop PCs, laptops). While having multiple devices provides new opportunities to work in the face of changing resource deprivations, the management of devices is often problematic. The most salient problems are posed by 1) the physical effort demanded by various management tasks, 2) anticipating what data or functionality will be needed, and 3) aligning these efforts with work, mobility, and social situations. Workers' strategies of coping with these problems center on two interwoven activities: the physical handling of devices and cross-device synchronization. These aim at balancing risk and effort in immediate and subsequent use. Workers also exhibit subtle ways to handle devices in situ, appropriating their physical and operational properties. The design implications are discussed.
Impact of Metformin on Endothelial Ischemia-Reperfusion Injury in Humans In Vivo: A Prospective Randomized Open, Blinded-Endpoint Study (2014)

ClinicalTrials.gov NCT01610401.
Nuclear magnetic resonance imaging of induced renal lesions. (1983)

Nuclear magnetic resonance (NMR) images obtained after unilateral ligation of the ureter, renal artery, or renal vein in the rat were analyzed and compared with NMR images of the normal rat kidney. Anatomic and functional correlation of the induced renal lesions was made by concurrent CT and by gross examination of the excised kidneys. Many normal anatomic structures at the level of the renal hilum can be identified by high resolution NMR imaging. Differentiation of urine from renal parenchyma permits detection of gross changes both in renal function and in the mass of the renal parenchyma. NMR imaging is capable of diagnosing hydronephrosis, acute renal ischemia, and acute venous congestion in this rat model. In addition, a trend toward prolongation of the relaxation times T1 and T2 for abnormal renal parenchyma is demonstrated.
An Efficient Hybrid Finite-Element Analysis of Multiple Vias Sharing the Same Anti-Pad in an Arbitrarily Shaped Parallel-Plate Pair (2015)

A hybrid 3-D and equivalent 2-D finite-element method (FEM) is proposed for signal/power integrity analysis of multiple vias in a shared anti-pad in an arbitrarily shaped parallel-plate pair. The entire domain of the plate pair is decomposed into via-domains and plate domains by virtual interfaces. Complicated fields in via-domains, due to mode conversions from transverse electromagnetic modes in anti-pads or via-holes to parallel-plate modes, are described by a 3-D FEM while in plate domains, only the zeroth-order parallel-plate modes are assumed to exist a little far away from anti-pads. Triangular prism elements are utilized in both via-domains and plate domains. It is proven that the 3-D triangular prism element can be reduced to an equivalent 2-D triangle element by a novel edge numbering process and the boundary conditions along the interfaces of via-domains and plate domains can be automatically satisfied. The accuracy of the hybrid method has been validated by comparison with other numerical methods, and its flexibility, as well as efficiency, are also demonstrated.
A stimulatory role of ozone exposure on human natural killer cells (2013)

Ozone is claimed to have beneficial effects. While studies revealed the safe therapeutic use of ozone, there are conflicting results for the link between immune system and ozone encounter. Natural killer (NK) cells are important sentinels of immunity with their cytotoxic activity and immune-regulatory potentials. This study aimed to investigate the effects of direct ozone encountering on human immune system, at cellular level. Survival, proliferative capacity and subset content of peripheral blood mononuclear cells (PBMC) were analysed. PBMC of healthy donors (n=5, mean age: 27±6 years) were exposed to 1, 5, 10 and 50 µg/mL doses of medical ozone, directly injected into culture wells, once, initially. 1 and 5 µg/mL doses didn't show toxic effects while 10 and 50 µg/mL doses were toxic. PBMC were cultured for 5 days following 1 and 5 µg/mL ozone encountering. 1 µg/mL dose increased numbers of CD3-CD16+/56+ NK cells among PBMC. Following stimulation with ozone, no difference was observed in basal and phytohemaglutinin-stimulated proliferative capacity. 1 and 5 µg/mL doses of ozone were found to increase NK cytotoxicity. These data indicates influential effects of transient ozone exposure on NK cells, which in turn may have a role in control of immune responses.
Contribution to Skin Cancer Prevention in South Africa: Modelling the UV Index Utilizing Imprecise Data (2002)

Abstract: South Africa has a high incidence of skin cancer and eye disorders because of the high number of sunshine hours per day. The ultraviolet (UV) index (UVI) provides a factual measure of the UV irradiance including biological effects. It is considered extremely important when gauging ultraviolet doses. A survey conducted across South Africa during January 1999 provided data records that contain nine independent variables for UVI inference purposes. This set of data includes cloud cover and other subjectively observed variables such as turbidity. The data set was recorded at 272 locations. Modelling the UVI by standard regression techniques using this data failed to produce reliable models for UVI prediction. The imprecision in some of the variables and small sample size implied that much more sophisticated techniques should be used. In the current research we resorted to artificial neural networks (ANNs) to cluster the data and then to model the UVI estimate in each of the data clusters. In the ANN training, we utilized the weights pruning method of optimal brain surgeon type to enable good generalization of the ANN models. The results obtained in the UVI assessment by this method produced results of significant accuracy.
Identification, physical map location and sequence of the<i>den V</i>gene from bacteriophage T4 (1984)

The denV gene from bacteriophage T4, which codes for endonuclease V, a small DNA repair enzyme, has been cloned and identified by an approach combining DNA sequencing and genetics, independent of the phenotypic effect of the cloned gene. Appropriate DenV+ and DenV- deletion mutants were mapped physically to define precisely a region encompassing the denV gene. This region was sequenced in order to identify a protein-coding sequence of the correct size for the denV gene (400-500 bp). Finally, identification was confirmed by sequencing the corresponding fragments cloned from four genetically and phenotypically well-characterized denV mutants. The denV gene is located at 64 kb on the T4 genome, adjacent to the ipII gene, and codes for a basic protein of 138 amino acids with a deduced molecular weight of 16,078.
Beautiful concurrency (2007)

The free lunch is over. We have grown used to the idea that our programs will go faster when we buy a next-generation processor, but that time has passed. While that next-generation chip will have more CPUs, each individual CPU will be no faster than the previous year’s model. If we want our programs to run faster, we must learn to write parallel programs. Parallel programs execute in a non-deterministic way, so they are hard to test and bugs can be almost impossible to reproduce. For me, a beautiful program is one that is so simple and elegant that it obviously has no mistakes, rather than merely having no obvious mistakes. If we want to write parallel programs that work reliably, we must pay particular attention to beauty. Sadly, parallel programs are often less beautiful than their sequential cousins; in particular they are, as we shall see, less modular. In this tutorial chapter I describe Software Transactional Memory (STM), a promising new approach to programming shared-memory parallel processors, that seems to support modular programs in a way that current technology does not. By the time we are done, I hope you will be as enthusiastic as I am about STM. It is not a solution to every problem, but it is a beautiful and inspiring attack on the daunting ramparts of concurrency. Code download (Cabalised) Discussion wiki page
Preliminary Results of Pressure Drop Modeling During Flow Boiling in Open Microchannels With Uniform and Tapered Manifolds (OMM) (2013)

Flow boiling with microchannel can dissipate high heat fluxes at low surface temperature difference. A number of issues, such as instabilities, low critical heat flux (CHF) and low heat transfer coefficients, have prevented it from reaching its full potential. A new design incorporating open microchannels with uniform and tapered manifold (OMM) was shown to mitigate these issues successfully. Distilled, degassed water at 80 mL/min is used as the working fluid. Plain and open microchannel surfaces are used as the test sections. Heat transfer and pressure drop performance for uniform and tapered manifold with both the surfaces are discussed. A low pressure drop of 7.5 kPa is obtained with tapered manifold and microchannel chip at a heat flux of 263 W/cm2 without reaching CHF. The pressure drop data is further compared with the homogenous model and the initial results are presented.
资本主义旧车的驾驶技术——美国、西德、英国市场资本主义宏观控制系统的比较研究 (1985)

市场资本主义的宏观控制 一辆很好的新车碰上糟糕的司机,可能一路折腾;一辆过时的旧车由有经验的司机驾驶,也可以一路平安;不过,旧车也会碰上坏司机。市场资本主义并非一辆好车,它不能使生产潜力充分发挥,这就需要司机知道如何来驾驶这辆旧车,以弥补其不足,而这又涉及市场资本主义的宏观控制系统。
HUMAN GENE MAPPING: A COMPENDIUM (1994)

The current status of the human genome map with information through 8 January 1996 A comprehensive listing of mapped human genes, anonymous DNA segments, and polymorphic markers In the years since the first Human Gene Mapping Conference in 1973, the number of genes included in the Genome Data Base has reached 5,902. In the past several years, there has been enormous growth not only in the numbers of markers localized to the map but also in the speed of the process of placement of such markers. This compendium provides a convenient summary list of markers and abbreviated literature citations to indicate which mapping reagents are available. While the most current information on the human genome can be obtained via on-line GDB, the annual published reports on the status of the human gene map are a valuable resource for the extensive research community engaged in genetic and physical mapping of the human genome. Starting with the 1993 compendium, this publication has supplanted the previous 'Chromosome Coordinating Meeting' report and the 'Human Gene Mapping' volumes. ' 'Reflecting the editing of the Genome Data Base through 8 January 1996, 'Human Gene Mapping, 1995' includes (as have the prior publications) the most recent reports of the chromosome mapping committees as well as reports from the nomenclature, comparative mapping, linkage, neoplasia, and clinical disorders committees.
Rapid Onset of Action of Levodopa in Restless Legs Syndrome: A Double-Blind, Randomized, Multicenter, Crossover Trial (1999)

Levodopa/benserazide is effective and safe in the treatment of RLS. Objective and subjective measures of sleep improved rapidly after the first dose. RLS symptoms recurred immediately after treatment was discontinued.
Multicasting in mobile backbone based ad hoc wireless networks (2006)

The synthesis of efficient and scalable multicasting schemes for mobile ad hoc networks is a challenging task. Multicast protocols typically construct a tree or mesh structure to distribute messages to multicast group members. Generally, these implementations impose scalability and efficiency limitations since they employ protocols that are based on a flat-topology networking architecture. We present three multicast algorithms that employ a dynamically synthesized mobile backbone network (MBN) to achieve efficient message distribution among members of multicast groups. Using the synthesized backbone network (BNet), we have a hierarchical networking architecture that enables a multicast protocol to achieve low control overhead and high transmission efficiency. The multicast algorithms under investigation are: (1) BNet flooding multicast algorithm (BFMA); (2) shared backbone multicast subnetwork (SBMS); (3) hybrid multicast algorithm (HMA). Our simulation and mathematical analysis results demonstrate the enhanced performance achieved by these MBN-based multicast algorithms when compared to ODMRP, and provide performance comparisons for these algorithms
A Designed Protein for the Specific and Covalent Heteroconjugation of Biomolecules (2008)

Bioconjugations often rely on adaptor molecules to cross-link different biomolecules. In this work, we introduce the molecular adaptor covalin, which is a protein chimera of two self-labeling proteins with nonoverlapping substrate specificity. Covalin permits a selective and covalent heteroconjugation of biomolecules displaying appropriate functional groups. Examples for the use of covalin include the specific heteroconjugation of a reporter enzyme to an antibody and of molecular probes to the surface of living cells. The efficiency and specificity of covalin-based bioconjugations together with the availability of a large variety of substrates create immediate and ubiquitous applications for covalin in bioconjugate chemistry.
Triplex-Forming Oligonucleotides as Potential Tools for Modulation of Gene Expression (2005)

Triplex-forming oligonucleotides (TFOs) bind in the major groove of duplex DNA at polypurine/ polypyrimidine stretches in a sequence-specific manner. The binding specificity of TFOs makes them potential candidates for use in directed genome modification. A number of studies have shown that TFOs can introduce permanent changes in a target sequence by stimulating a cell's inherent repair pathways. TFOs have also been demonstrated to inhibit gene expression providing a possible role for these compounds in cancer therapy. This review summarizes the dual roles of TFOs for use in delivering DNA reactive compounds to a specific site in the genome or for introducing permanent changes in the target sequence through the introduction of an altered helical structure. In addition to compiling the ways in which TFOs have been successfully utilized, this review will explore conflicting reports of TFO bioactivity focusing on the variables which affect the efficacy in vitro of TFO mediated genomic modification which in turn may represent the obstacles encountered using TFOs to modulate gene expression in vivo.
EFFECTS OF THERMAL DISPERSION AND TURBULENCE IN FORCED CONVECTION IN A COMPOSITE PARALLEL-PLATE CHANNEL: INVESTIGATION OF CONSTANT WALL HEAT FLUX AND CONSTANT WALL TEMPERATURE CASES (2002)

Abstract In this article, a composite parallel-plate channel whose central portion is occupied by a clear fluid and whose peripheral portion is occupied by a fluid saturated porous medium, is considered. The flow in the porous region of the channel is assumed to be laminar, governed by the Brinkman-Forchheimer-extended Darcy equation, while the flow in the clear fluid region of the channel is assumed to be turbulent. The validity of this laminar/turbulent assumption is validated by estimating Reynolds numbers in the clear fluid and porous regions of the channel. Although the flow in the porous region remains laminar, it is still fast enough for the quadratic drag (Forchheimer) effects to be important. In this situation, hydrodynamic mixing of the interstitial fluid at the pore scale becomes important and may cause significant thermal dispersion. It is shown that thermal dispersion may result in some counterintuitive effects, such as the increase of the Nusselt number when the width of the clear fluid region in the center of the channel is decreased.
Depth dependence of the low frequency propagation loss for the sea surface noise sources (1987)

The depth dependent sound fields have been calculated for a single frequency source to reveal the fluctuating sound energy at both near the surface and the bottom of the water layer. Those fluctuation are mainly due to the mode function behavior along the depth where the sound-speed gradient acts like trapping lower mode sound energy in those medium.
High-resolution tactile display operated by an integrated 'Smart Hydrogel' actuator array (2010)

Here we introduce a high-resolution tactile display based on the integration of 4,320 actuators with a density of about 300 actuators per cm<sup>2</sup> into an array displaying both visual and tactile information. The actuators are fabricated simultaneously by UV-patterning. Intrinsically active polymers called "smart hydrogels" are used as actuators which are sensitive to changes in temperature. The high resolution temperature field is controlled by a computer using an optical interface that is controlled by a computer. Thus the temperature is adjusted for each actuator and it can be independently controlled. An actuator pixel changes color from transparent to opaque providing a visual monochrome functionality. The altitude and the elasticity change as well. Therefore the tactile display is able to generate artificial impressions about contours, textures, profiles and the softness of a surface. The actuators are covered by a thin foil equipped with knobs, which can additionally vary the tactile impressions. For fabrication an inexpensive modified dry photoresist technology was used for the masters of up to (200 × 155) mm<sup>2</sup>. This device demonstrates a high integration into MEMS with a monolithically fabricated actuator array of temperature-sensitive active polymer and an optoelectronic control.
Short Notices (1938)

Short Notices H. A. I. H. A. I. Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LIII, Issue CCXI, July 1938, Pages 549–550, https://doi.org/10.1093/ehr/LIII.CCXI.549 Published: 01 July 1938
Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease (2011)

Evidence for the involvement of the three TLRs tested in a variety of human renal diseases was found. These findings add to our understanding of the role of the innate immune system in kidney disease.
Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond (1989)

The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were tested in vitro for their ability to inhibit human plasma renin. Replacement of the scissile bond with the phosphinic analogue of Leu10-Val11 (1b) gave the most potent inhibitors, having IC50 = 7.5 x 10(-8) M for H-Pro-His-Pro-Phe-His-(1b)-Ile-His-Lys-OH and IC50 = 1.0 x 10(-7) M for Z-Arg-Arg-Pro-Phe-His-(1b)-Ile-His-NH2. The shorter phosphonic acid sequence Z-Pro-Phe-His-(1d) retained biological activity with an IC50 = 6.4 x 10(-6) M.
Equilibrium Separation and Filtration of Particles Using Differential Inertial Focusing (2008)

Rapid separation and filtration of particles in solution has a wide range of applications including blood cell separation, ultrasound contrast agent preparation, and purification of fermentation products. However, current techniques that provide quick processing rates are high in complexity. We present a rapid microfluidic filtration technology capable of separating particles based on size, with purities from 90 to 100% and high-volume throughputs of 1 mL/min. Data for separation of rigid particles, deformable emulsions, and platelets from whole blood are presented. The system is based upon differential inertial focusing of particles of varying sizes and allows continuous separation based only on intrinsic hydrodynamic forces developed in a flow through an asymmetrically curved channel. A theoretical description of the underlying forces is developed, and in combination with data determining a size cutoff for separation, a semiempirical relationship describing how channel geometry is related to this cutoff is shown. Cascading separations in series is shown to be useful for increasing purity and yield. This type of microfluidic system can filter deformable particles, is largely independent of particle density, and can provide throughputs typical of macroscale filtration in a compact format, enabling applications in blood filtration and particle concentration.
Possible antitumor activity of 1‐(3‐<i>C</i>‐ethynyl‐β‐<scp>d</scp>‐<i>ribo</i>‐pentofuranosyl)cytosine (ECyd, TAS‐106) against an established gemcitabine (dFdCyd)‐resistant human pancreatic cancer cell line (2005)

We established a variant of MIAPaCa-2 human pancreatic cancer cells that is resistant to 2',2'-difluorodeoxycytidine (gemcitabine, dFdCyd), MIAPaCa-2/dFdCyd, and elucidated the biochemical characteristics and mechanism of dFdCyd-resistance in these cells. We also evaluated 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106, RNA polymerase inhibitor), a new anticancer ribonucleoside, for antitumor activity against the resistant cells in vitro and in vivo. MIAPaCa-2/dFdCyd cells were 2541-fold more resistant to dFdCyd than parental MIAPaCa-2 cells, and the major mechanism of the dFdCyd-resistance was found to be a decrease in the intracellular pool of dFdCyd and its active metabolites, which would result in a decrease in incorporation of dFdCyd triphosphate into DNA. This finding was confirmed by the discovery of decreased deoxycytidine kinase activity, increased cytidine deaminase and ribonucleotide reductase activity, and increased 5'-nucleotidase mRNA expression in the MIAPaCa-2/dFdCyd cells. The cytotoxicity of TAS-106 as an antitumor nucleoside analog was similar in both parental and dFdCyd-resistant cells, with IC(50) values of 6.25 and 6.27 nM, respectively, and this finding was supported by similar intracellular uptake and metabolism of TAS-106 in both cell lines. We also evaluated the in vivo antitumor activity of TAS-106 against MIAPaCa-2 and dFdCyd-resistant MIAPaCa-2/dFdCyd tumors implanted into nude mice. The tumor growth inhibition rate of weekly additions of TAS-106 (7 mg/kg, iv) against parental and dFdCyd-resistant tumors was 73% and 76%, respectively, while that of dFdCyd administered twice a week (240 mg/kg, iv) was 84% and 34%, respectively. These results suggest that TAS-106 would contribute to the treatment of patients with advanced pancreatic carcinomas in whom dFdCyd-based chemotherapy has failed.
A layered and distributed approach to platform systems control (2003)

With the increasing complexity of platform systems and the ongoing demand for reduced manning comes the need for novel approaches to ship control systems. Current control and management systems fall short on maintainability, robustness and scalability. From the operator's perspective information handling has become a demanding task due to the multitude of alarms and data available. To deal with these issues, the Maritime Command & Control group of TNO-FEL pursues a distributed and layered approach to damage & platform control with particular attention to alarm-management. At the lowest level a multi-agent organization is responsible for immediate emergency response. The reactive and adaptive nature of this layer ensures quick isolation of faults and helps to preserve the system's functional integrity. On a higher level the situation is assessed more in depth so that recovery plans can be formulated. The top level provides the user with control options and means to express specific demands from the operational context. By joining the various parts of the architecture in a subsumption-like manner a robust and scalable system is created. To demonstrate these principles a software prototype for a watercooling system aboard navy frigates is being developed for the Royal Dutch Navy.