gebhart/patrepeval huggingface dataset:
Review: Potential protective effects of telmisartan on renal function deterioration (2006)

Experimental and clinical evidence is now available that antagonism of angiotensin II (Ang II) with both angiotensin-converting enzyme inhibitors and Ang II receptor antagonists (AIIAs) is effective in slowing the rate of renal functional loss in patients affected by proteinuric kidney diseases. Among AIIAs, telmisartan has been shown to be characterised by a potent and long lasting antihypertensive effect that may be associated with another specific effect of this molecule, the partial agonism of the peroxisome-activated receptor-gamma. Although this action has also been observed with other AIIAs, telmisartan seems to exert a more effective and specific action as in such a way to influence beneficially adipocyte metabolism, diabetes onset and insulin resistance. Recently, we have demonstrated, at the experimental and clinical level, that sustained blockade of Ang II biological activity with this class of compounds can potentially reduce the progression of renal dysfunction and in some circumstances induce the regression of renal functional and structural changes. In this review we analyse available experimental and clinical data that suggest that blocking Ang II with telmisartan may effectively ameliorate renal dysfunction in patients affected by the now frequently observed condition termed metabolic syndrome.
Evaluation of the Performance of a Novel System for Continuous Glucose Monitoring (2013)

The performance of this prototype CGM system was, particularly in the hypoglycemic range and during phases with rapid glucose fluctuations, better than performance data reported for other commercially available systems. In addition, performance of this prototype sensor was noticeably constant over the whole study period. This prototype system is not yet approved, and performance of this CGM system needs to be further assessed in clinical studies.
Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma (2014)

TFF3 expression predicts metastasis and poor survival outcome of patients with MC and functionally stimulates cellular invasion and metastasis of ER+ MC cells. Adjuvant functional inhibition of TFF3 may therefore be considered to ameliorate outcome of ER+ MC patients.
Residues Arg283, Arg285, and Ile287 in the Nucleotide Binding Pocket of Bovine Viral Diarrhea Virus NS5B RNA Polymerase Affect Catalysis and Fidelity (2012)

Residues Arg283, Arg285, and Ile287 are highly conserved amino acids in bovine viral diarrhea virus RNA polymerase (BVDV RdRp) and RdRps from related positive-strand RNA viruses. This motif is an important part of the binding pocket for the nascent RNA base pair during initiation and elongation. We found that replacement of the arginines with alanines or more conserved lysines or replacement of isoleucine with alanine or valine alters the ability of the mutant RdRps to incorporate ribonucleotides efficiently. The reduced RdRp activity stems from both decreased ribonucleotide binding and decreased catalytic efficiency in both primer-dependent and de novo initiation, as shown by kinetic studies. In line with other studies on flaviviral RdRps, our data suggest that Arg283 and Ile287 may be implicated in ribonucleotide binding and positioning of the template base in the active site. Arg285 appears to be involved directly in the selection of cognate nucleotide. The findings for Arg285 and Ile287 mutants also agree with similar data from picornavirus RdRps.
Thermal vaporisation for inductively coupled plasma optical emission spectrometry. A review (1986)

H. Matusiewicz, J. Anal. At. Spectrom., 1986, 1, 171 DOI: 10.1039/JA9860100171
Critical Review of Prostate Cancer Predictive Tools (2009)

Prostate cancer is a very complex disease, and the decision-making process requires the clinician to balance clinical benefits, life expectancy, comorbidities and potential treatment-related side effects. Accurate prediction of clinical outcomes may help in the difficult process of making decisions related to prostate cancer. In this review, we discuss attributes of predictive tools and systematically review those available for prostate cancer. Types of tools include probability formulas, look-up and propensity scoring tables, risk-class stratification prediction tools, classification and regression tree analysis, nomograms and artificial neural networks. Criteria to evaluate tools include discrimination, calibration, generalizability, level of complexity, decision analysis and ability to account for competing risks and conditional probabilities. The available predictive tools and their features, with a focus on nomograms, are described. While some tools are well-calibrated, few have been externally validated or directly compared with other tools. In addition, the clinical consequences of applying predictive tools need thorough assessment. Nevertheless, predictive tools can facilitate medical decision-making by showing patients tailored predictions of their outcomes with various alternatives. Additionally, accurate tools may improve clinical trial design.
Sintering and characterization of Gelcast alumina-chromia reaction bonded ceramics (1995)

The reaction bonding mechanism and the consolidation behaviour of Al{sub 2}O{sub 3}/Cr mixtures under different processing conditions have been investigated. The oxidation of the metal in the dried gelcast green-bodies of about 56 % density starts at temperatures as low as 450{degrees}C but mainly occurs between 800{degrees} and 1100{degrees}C. Complete densification was not achieved mainly due to the formation of a non sinteractive Cr{sub 2}O{sub 3} structure caused by the coarse metal particles. The sintering process is hindered by the binding of the alumina particles during the formation of the (Al, Cr){sub 2}O{sub 3} solid solution.
A method for isolation of milk fat globules (1986)

The traditional procedure for isolating milk fat globules involves repeated cycles of centrifuging to obtain globules and redispersion of them in fresh buffer to eliminate other milk components. We have evaluated a simpler, less manipulative method whereby globules are centrifuged out of the milk and through an overlying buffer layer. Human milk samples ranging from 0.1 to 35 ml were centrifuged at 1500 X g for 20 min after deposition under a suitable quantity of buffer. This yielded purified globules, in less time, which could be dispersed more satisfactorily than those by the traditional procedure. Protein, phospholipid and cholesterol contents of globules by the two methods were quite similar. A lower protein content (10.4 vs 13.2 mg/g of lipid) was characteristic of globules prepared by the multiple wash method. However, large differences could not be seen in gel electrophoresis patterns of the proteins. By using plastic centrifuge tubes, tube freezing and cleavage just below the globule layer enables clean separation of globule and nonglobule phases for analysis of milk component distributions. Macro (5 to 35 ml of sample) and micro (200 microliter or less) versions of the method are described. Limited trials showed that the method can be applied satisfactorily to cow's and goat's milks, but for highly pure globules a deeper buffer column than that used with human milk is required because of their much higher casein content.
Long-Term Reduction in Peripheral Blood HIV Type 1 Reservoirs Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation (2013)

The ability of donor cells to engraft without evidence of ongoing HIV-1 infection suggests that HIV-1 replication may be fully suppressed during cART and does not contribute to maintenance of viral reservoirs in peripheral blood in our patients. HSCTs with wild-type-CCR5(+) donor cells can lead to a sustained reduction in the size of the peripheral reservoir of HIV-1.
A monolith purification process for virus-like particles from yeast homogenate (2011)

Monoliths are an alternative stationary phase format to conventional particle based media for large biomolecules. Conventional resins suffer from limited capacities and flow rates when used for viruses, virus-like particles (VLP) and other nanoplex materials. The monolith structure provides a more open pore structure to improve accessibility for these materials and better mass transport from convective flow and reduced pressure drops. To examine the performance of this format for bioprocessing we selected the challenging capture of a VLP from clarified yeast homogenate. Using a recombinant Saccharomyces cerevisiae host it was found hydrophobic interaction based separation using a hydroxyl derivatised monolith had the best performance. The monolith was then compared to a known beaded resin method, where the dynamic binding capacity was shown to be three-fold superior for the monolith with equivalent 90% recovery of the VLP. To understand the impact of the crude feed material confocal microscopy was used to visualise lipid contaminants, deriving from the homogenised yeast. It was seen that the lipid formed a layer on top of the column, even after regeneration of the column with isopropanol, resulting in increasing pressure drops with the number of operational cycles. Removal of the lipid pre-column significantly reduces the amount and rate of this fouling process. Using Amberlite/XAD-4 beads around 70% of the lipid was removed, with a loss of VLP around 20%. Applying a reduced lipid feed versus an untreated feed further increased the dynamic binding capacity of the monolith from 0.11 mg/mL column to 0.25 mg/mL column.
Myocardial contractile reserve during exercise predicts left ventricular reverse remodelling after cardiac resynchronization therapy (2009)

Myocardial contractile reserve (global and regional) is a strong predictive factor of LV reverse remodelling after CRT.
Naloxone Antagonism of Corticotropin-Releasing Hormone Stimulation of Prolactin Secretion in Rhesus Monkeys* (1989)

The effect of opiate receptor blockade on human CRH-induced PRL secretion was examined in ovariectomized and normal female rhesus monkeys. A bolus iv dose of 100 micrograms CRH acutely stimulated PRL secretion in both normal and ovariectomized animals. The magnitude of the PRL response was greater in ovariectomized monkeys (212% increase; n = 5) than in normal monkeys (56% increase; n = 5). Naloxone pretreatment inhibited CRH-induced PRL release in a dose-dependent fashion, whereas nalmefene did not, in both normal and ovariectomized monkeys. Administration of nalmefene alone significantly stimulated PRL secretion in normal monkeys (57% increase; n = 10), but not in ovariectomized monkeys (10% increase; n = 10). Naloxone alone had no effect. Since nalmefene has a high affinity for both the kappa- and mu-receptors whereas naloxone binds primarily to the mu-receptor, these results suggest that CRH-induced PRL secretion in monkeys is mediated by an endogenous opiate which binds to an opiate receptor other than or in addition to the mu- and kappa-receptors.
Depth map generation using a single image sensor with phase masks (2016)

Conventional stereo matching systems generate a depth map using two or more digital imaging sensors. It is difficult to use the small camera system because of their high costs and bulky sizes. In order to solve this problem, this paper presents a stereo matching system using a single image sensor with phase masks for the phase difference auto-focusing. A novel pattern of phase mask array is proposed to simultaneously acquire two pairs of stereo images. Furthermore, a noise-invariant depth map is generated from the raw format sensor output. The proposed method consists of four steps to compute the depth map: (i) acquisition of stereo images using the proposed mask array, (ii) variational segmentation using merging criteria to simplify the input image, (iii) disparity map generation using the hierarchical block matching for disparity measurement, and (iv) image matting to fill holes to generate the dense depth map. The proposed system can be used in small digital cameras without additional lenses or sensors.
DELETIONS OF THE ISO-1-CYTOCHROME <i>c</i> AND ADJACENT GENES OF YEAST: DISCOVERY OF THE <i>OSM1</i> GENE CONTROLLING OSMOTIC SENSITIVITY (1978)

Some of the deletions in the yeast Saccharomyces cerevisiae that encompass the CYC1 gene, which determines iso-1-cytochrome c, extend into the OSM1 gene, causing inhibition of growth on hypertonic media, and into the RAD7 gene, causing sensitivity to UV light. Two deletions (cyc1--363 and cyc1--367) encompass only the CYC1 gene, two deletions (cyc1--366 and cyc1--368) encompass the CYC1 and OSM1 genes, three deletions (cyc1--1, cyc1--364 and cyc1--365) encompass the CYC1, OSM1 and RAD7 genes, while none of the deletions extend into the closely linked SUP4 gene.
A bandgap voltage reference using digital CMOS process (2002)

This work describes some issues and criteria for the design of a bandgap voltage reference. It examines a particular voltage reference architecture, characteristics of the operational amplifier, parasitic bipolar transistor biasing currents and the start-up circuit. Test circuits have been fabricated in the AMS 0.8 /spl mu/m n-well CMOS process. Experimental results yield an output voltage which is constant within 0.72% over the temperature range of -40/spl deg/C to 95/spl deg/C and the power supply range of 5 V/spl plusmn/10%.
Water-dispersable colloidal quantum dots for the detection of ionizing radiation (2013)

Fluorescent CdSe-CdS-Cd0.5Zn0.5S-ZnS core-shell colloidal quantum dots (cQDs) dispersed in aqueous and organic solvents have been prepared and used as scintillators for detecting ionizing radiation. Results demonstrate a linear relationship between emitted luminescence and dose-activity. These results suggest that cQDs alone could be used as liquid scintillators for specific environmental and medical applications.
Deletion ofDad1 in mice induces an apoptosis-associated embryonic death (2000)

Dad1 is a putative anti-apoptosis gene identified in several distantly related organisms. Expression of Dad1 in transfected cells inhibits apoptosis in vitro. To determine whether Dad1 has a similar function in vivo, we used gene targeting to delete Dad1. Heterozygous adult mice (+/-) show no obvious phenotype or abnormalities, but genotype analysis of over 100 offspring from heterozygous matings detected no weanling, homozygous Dad1 null (-/-) mice. Subsequent analysis of embryos from heterozygous matings detected Dad1 null (-/-) embryos at E3.5 but no later, suggesting Dad1 is required for development beyond the late blastocyst stage. Increased levels of apoptosis were observed in cultured embryos lacking a functional copy of the gene, consistent with an anti-apoptotic role for Dad1.
Graphics Gems V: MacIntosh Versiion (1995)

From the Publisher:
Graphics Gems V offers innovative solutions to real graphics programming problems. The newest volume in the series continues to provide practical tools for implementing new ideas and technifques into your programs. Alan Paeth has edited a beautifully crafted set of new gems reflecting the current research and technifques in the field. All of the gems included are self-contained and independent of earlier volumes. * All newly crafted gems * Includes a cumulative index for all five volumes for easy referencing * Provides code written in C or C++ on disks that may be implemented into new or existing programs * Contains a color insert, demonstrating the results of some of the techniques
Microstructured anti-reflection surface design for the omni-directional solar cells (2008)

In this paper, a new process for the formation of hemispherical structures as an omni-directional anti-reflection (omni-AR) coating in solar cell is reported. We also demonstrated the simulation results of the angular and spectral dependences of the total reflectivity on various micro-structured surfaces. Close to zero reflection can be achieved in some micro-structured surfaces over an extended spectral region for large ranges of incident light angles. Daily generated current in such hemispherical solar cells hence enhanced to 1.5 times of bulk silicon solar cells. The impact of feature size, density, shape and refractive index has all been investigated. The experimental results agree reasonably well with the theoretical work. Such an omni-AR structure offers an attractive solution to current bulk crystalline silicon solar cells, as well as thin film, organic and future quantum based solar cells.
Dendromesogens: Liquid Crystal Organizations of Poly(amidoamine) Dendrimers versus Starburst Structures (2001)

A new series of liquid crystalline poly(amidoamine) (PAMAM) dendrimers is described. These dendrimers are made by attaching to the 0-, 1-, 2-, 3-, and 4-generation of PAMAM-terminal promesogenic units that carry two decyloxy chains in the 3- and 4-positions of their peripheral aromatic ring. X-ray diffraction studies show that all the compounds display a hexagonal columnar mesophase. A high density of aliphatic chains imposes a curved interface with the promesogenic units that forces the molecules to adopt a radial conformation, and therefore, the columnar structure. A model for the supramolecular organization of the different generations within the columnar mesophase is proposed based on the variation of some of the structural parameters.
Non-Invasive Brain Computer Interface for Mental Control of a Simulated Wheelchair (2006)

SUMMARY: This poster presents results obtained from experiments of driving a brain-actuated simulated wheelchair that incorporates the shared-control intelligence method. The simulated wheelchair is controlled offline using band power features. The task is to drive the wheelchair along a corridor avoiding two obstacles. We have analyzed data from 4 naïve subjects during 25 sessions carried out in two days. To measure the performance of the brain-actuated wheelchair we have compared the final position of the wheelchair with the end point of the desired trajectory. The experiments show that the incorporation of a higher intelligence level in the control device significantly helps the subject to drive the robot device. trained with data from 5 consecutive sessions and tested over the next 5 consecutive sessions. To measure the performance of the brain-actuated wheelchair we have compared the final position of the wheelchair with the end point of the desired trajectory.
Blind Comparison of Patient Preference for Flavored Colestid Granules and Questran Light (1993)

Questran Light was significantly preferred on a sensory basis when mixed in orange juice. Flavored Colestid Granules was significantly preferred over Questran Light for both sensory and mixability characteristics with water as the vehicle.
Estimation of network link loss rates via chaining in multicast trees (2002)

Of increasing importance is estimation of internal link parameters in communications networks. Multicast probes are a way to gather statistics about internal links from edge node measurements. The problem of estimating link loss probabilities for a multicast distribution tree is examined. Our model assumes loss statistics are distributed to session participants by a network protocol such as RTCP. We propose a decentralized algorithm for ML estimation of the link loss probabilities in a chain of nodes rooted at the source node of the multicast distribution tree and terminating at a given leaf. An expression for the Cramer-Rao bound and an approximate form for the probability distribution function of the estimator are given. The performance of the algorithm is evaluated using computer simulations for a bottleneck detection application.
Breast Density Analysis in 3-D Whole Breast Ultrasound Images (2006)

The breast density information is one of important factors for estimating the risk in breast cancer detection and early prevention. In this paper, we present two methods, including threshold-based and proportion-based, to automatically analyze the breast density using whole breast ultrasound. The two algorithms are experimented with 32 cases which are scanned from 32 patients using the US machine SSD-5500 with a recent developed scanner ASU-1004 (Aloka, Japan). The experimental results are graded from 4 (extremely dense tissue) to 1 (almost entirely fat), and respectively compared with the majority grades of three radiologists. The accuracy of the threshold-based and proportion-based strategies is 88% and 84% respectively.
Speculative Versioning Cache (2001)

Dependences among loads and stores whose addresses are unknown hinder the extraction of instruction level parallelism during the execution of a sequential program. Such ambiguous memory dependences can be overcome by memory dependence speculation which enables a load or store to be speculatively executed before the addresses of all preceding loads and stores are known. Furthermore, multiple speculative stores to a memory location create multiple speculative versions of the location. Program order among the speculative versions must be tracked to maintain sequential semantics. A previously proposed approach, the Address Resolution Buffer (ARB) uses a centralized buffer to support speculative versions. Our proposal, called the Speculative Versioning Cache (SVC), uses distributed caches to eliminate the latency and bandwidth problems of the ARB. The SVC conceptually unifies cache coherence and speculative versioning by using an organization similar to snooping bus-based coherent caches. Our evaluation for the Multiscalar architecture shows that hit latency is an important factor affecting performance and private cache solutions trade-off hit rate for hit latency.
Extracting and visualizing trust relationships from online auction feedback comments (2007)

Buyers and sellers in online auctions are faced with the task of deciding who to entrust their business to based on a very limited amount of information. Current trust ratings on eBay average over 99% positive [13] and are presented as a single number on a user's profile. This paper presents a system capable of extracting valuable negative information from the wealth of feedback comments on eBay, computing personalized and feature-based trust and presenting this information graphically.