gebhart/patrepeval huggingface dataset:
Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells (2008)

The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown. Here we show that DOCK2, a hematopoietic cell-specific CDM family protein, is indispensable for migration of plasmacytoid DCs (pDCs), but not myeloid DCs (mDCs). Although DOCK2-deficiency did not affect development of pDCs, DOCK2-deficient (DOCK2(-/-)) mice exhibited a severe reduction of pDCs in the spleen and lymph nodes. Adoptive transfer experiments revealed that DOCK2(-/-) pDCs failed to migrate into the periarteriolar lymphoid sheaths of the spleen. In DOCK2(-/-) pDCs, chemokine-induced Rac activation was severely impaired, resulting in the reduction of motility and the loss of polarity during chemotaxis. In contrast, DOCK2(-/-) mDCs did not show any defects in Rac activation and migration. These results indicate that pDCs and mDCs use distinct molecules to activate Rac during chemotaxis.
Neighboring-group and substituent effects in the solvolysis of substituted .alpha.-bromophenylacetate ions (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNeighboring-group and substituent effects in the solvolysis of substituted .alpha.-bromophenylacetate ionsKenneth C. Kemp and Diana MetzgerCite this: J. Org. Chem. 1968, 33, 11, 4165–4168Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/jo01275a033https://doi.org/10.1021/jo01275a033research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiple target tracking using sequential monte carlo methods and statistical data association (2004)

This paper presents two approaches for the problem of multiple target tracking (MTT) and specifically people tracking. Both filters are based on sequential Monte Carlo methods (SMCM) and joint probability data association (JPDA). The filters have been implemented and tested on real data from a laser measurement system. Experiments show that both approaches are able to track multiple moving persons. A comparison of both filters is given and the advantages and disadvantages of the two approaches are presented.
A Simple Technique for the Determination of Delayed Maximal Length Linear Binary Sequences (1977)

The problem of delayed sequence generation from a central pseudorandom binary sequence generator is considered. In particular a simple algorithm is derived which permits the convenient determination of delayed sequences.
End user mobile task automation using multimodal programming by demonstration (2017)

Conversational agents are often used to perform tasks on smartphones, but existing conversational agents are limited in capabilities and lack of customizability. My work explores using the programming-by-demonstration approach to enable end users to program new tasks for conversational agents by demonstrating using the familiar graphical user interfaces of third-party apps. I propose to use a multi-modal (demonstration and verbal instruction) interface to support generalization, editing, error handling as well as creating control structures in creating such smartphone automation.
Il materiale laterizio nei cantieri del cosiddetto Padiglione della "Domus Aurea" (2015)

italianoPartendo dall'esempio della costruzione del cd. Padiglione della Domus Aurea, si propone uno sguardo generale sull’uso del materiale laterizio nei cantieri coinvolti in questo gigantesco progetto imperiale, tra i primi interamente concepiti e costruiti con questo materiale. Le osservazioni presentate, ancora preliminari, tendono a dimostrare che l’ambizioso e articolato progetto fu minuziosamente programmato fin dall’inizio, nonostante sia percepibile una certa diversificazione nei rifornimenti dei laterizi da un cantiere all’altro. Si accenna in particolare all’uso insolito di mattoni quadrati di 39 cm di lato (cd. “piccoli sesquipedali”) nelle primissime strutture ad essere state edificate; mattoni paragonabili al lotto particolarmente omogeneo, impiegato nella costruzione dell’ambulacro interno del Teatro di Marcello. E inoltre considerato l’esempio emblematico dell’edificazione della sala ottagonale, articolazione centrale dell’intero complesso, per la quale viene sorprendentemente impiegato un lotto di bessali di forma e qualita molto approssimativa insieme con una malta scarsamente accurata. Infine, alcune considerazioni vengono proposte sull’uso particolare del laterizio nella gestione delle aperture del complesso che mette in evidenza l’abilita dei costruttori neroniani sia di adottare e adattare soluzioni valide del passato, quale l’uso combinato di piattabande laterizie e prismoidi di travertino, che di sperimentare nuovi impieghi delle piattabande e degli archi di scarico in laterizio in questa fase iniziale dello sviluppo generalizzato dell'opus testaceum. EnglishStarting from the example of the so-called Pavilion of the Domus Aurea, an overview is offered of the use of brick in the construction of this huge imperial project, one of the first to have been conceived and built with this material. The observations here presented, although still preliminary, tend to demonstrate that this ambitious and complex project was meticulously planned from the beginning, despite some variation in brick supply from one building zone to another. In particular the paper highlights the unusual presence of bricks 39 cm square (the so-called “small sesquipedales”), used in the first structures to be erected. These bricks are comparable to the very homogeneous group in the inner ambulacrum of the Theatre of Marcellus. In addition the paper examines the construction of the emblematic Octagonal Hall, the fulcrum of the whole complex, where, surprisingly, very low-quality and roughly-shaped bessales were used together with a quite poor mortar. Finally, some suggestions are made about the distinctive use of brick in the openings of the whole complex, which highlight the ability of the Neronian builders, on the one side in adopting and adapting previously effective solutions, such as the combination of brick flat arches and travertine wedge-shaped blocks, and on the other in experimenting with new applications both of flat and relieving arches made of brick during this initial phase of the generalised development of opus testaceum.
Vibration Damping Using CCII-Based Inductance Simulators (2008)

In this paper, we present an application of second- generation current-conveyor (CCII)-based active inductance simulators to mechanical vibration damping. The oscillation amplitude of a metallic beam, which is near some resonant frequencies, can be reduced by converting mechanical energy into electrical energy through a piezoelectric transducer that is bonded to the beam. An electric circuit, which is made up of the piezoelectric transducer, a resistance, and an inductance, accomplishes the task of dissipating the energy. To this end, the natural frequency of the circuit should be close to the natural frequency of interest of the mechanical system. The high value that is requested for the inductance (thousands of Henrys) can only be achieved through an inductance-simulator circuit. In the literature, the circuit implementations of the inductance simulators are typically based on operational amplifiers, such as the Antoniou circuit. In this paper, we make use of the CCIIs, which allow us to obtain both grounded and floating equivalent inductances that work within a regulated frequency range from three to four decades. The effectiveness of the traditional inductance simulators and CCII-based simulators is discussed, comparing the responses of an experimental mechanical-electrical system, with different circuit implementations, through experimental results. The use of series-resistance compensation, which is obtained through the use of a suitable topology based on the CCIIs, in the implementation of the equivalent inductance, allows one to obtain the best vibration damping, as confirmed by measurements, for all the natural mechanical frequencies of the realized system.
Seismic displacements of geosynthetic-reinforced soil modular block walls (2003)

Four geosynthetic-reinforced soil modular block (GRS-MB) retaining walls that behaved differently during the 1999 Taiwan Chi-Chi earthquake were investigated by field surveying and soil testing. Pseudo-static analyses based on the two-wedge failure mechanism were performed to investigate the seismic stability of such GRS-MB walls. The analyses considered the structural function of the stacked block facing and the contribution of reinforcement-facing connection strength to the seismic stability of GRS-MB retaining walls. It was found that the facing-reinforcement connection strength and the block–block shear resistance strongly affect the seismic stability and seismic displacement of GRS-MB retaining walls. Newmark's sliding block theory together with a ‘displacement diagram’ were used to evaluate the seismic displacements of the investigated walls. The displacement analyses give the values of horizontal seismic displacement of the discrete modular block facing and the vertical settlement of the backfill soil. It was found that the calculated values of wall displacements were comparable with the measured ones when the structural effects of the facing were properly accounted for. The effect of buckling mode deformation of the stacked blocks on the horizontal displacement of the GRS-MB walls is also evaluated quantitatively.
Clinical and Histological Correlations of Decline in Renal Function in Diabetic Patients With Proteinuria (1994)

In 47 patients with diabetic nephropathy (29 type I, 18 type II) renal function and blood pressure (BP) (treated with or without an angiotensin-converting enzyme [ACE] inhibitor, enalapril [10 mg], in 38 hypertensive patients) were followed over 4 years. A percutaneous renal biopsy was performed in all patients initially and repeated in a representative 19 patients with treated hypertension after 4 years. Mean glomerular volume (MGV), interstitial fibrosis (IF), capillary volume, and sclerosed glomeruli (GS) were measured histomorphometrically. Mean fall in creatinine clearance (CCr) was 11.8% after 4 years with no difference between treatment groups or type of diabetes. BP both initially and during treatment correlated with initial and final serum creatinine and CCr (P < 0.01). There were no histomorphometric differences between type I and type II patients or hypertension treatment groups. Initial IF correlated with initial and final serum creatinine and CCr (P < 0.05) in all patients and type I patients alone, MGV correlated inversely with CCr in type I patients (P < 0.05). After 4 years, IF (24.8 vs. 30.0%, P < 0.01) and GS (26 vs. 37%, P < 0.05) increased significantly, and increase in IF correlated with fall in CCr (P < 0.01). Proteinuria and HbA1 did not correlate with indexes of function or structure. In this longitudinal study of patients with diabetic nephropathy, there was a close relation between BP and renal function but no difference between treatment with enalapril and other hypertensive agents. The correlations between renal function and histology at entry and after 4 years suggest that IF is a co-determinant of renal function in diabetic nephropathy.
Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity (2001)

Reduced plasma HDL cholesterol concentration has been associated with an increased risk of coronary heart disease. However, a low HDL cholesterol concentration is usually not observed as an isolated disorder because this condition is often accompanied by additional metabolic alterations. The objective of this study was to document the relevance of assessing HDL particle size as another feature of the atherogenic dyslipidemia found among subjects with visceral obesity and insulin resistance. For that purpose, an average HDL particle size was computed by calculating an integrated HDL particle size using nondenaturing 4-30% gradient gel electrophoresis. Potential associations between this average HDL particle size versus morphometric and metabolic features of visceral obesity were examined in a sample of 238 men. Results of this study indicated that HDL particle size was a significant correlate of several features of an atherogenic dyslipidemic profile such as increased plasma TG, decreased HDL cholesterol, high apolipoprotein B, elevated cholesterol/HDL cholesterol ratio, and small LDL particles as well as increased levels of visceral adipose tissue (AT) (0.33 < or = absolute value of r < or = 0.61, P < 0.0001). Thus, men with large HDL particles had a more favorable plasma lipoprotein-lipid profile compared with those with smaller HDL particles. Furthermore, men with large HDL particles were also characterized by reduced overall adiposity and lower levels of visceral AT as well as reduced insulinemic-glycemic responses to an oral glucose load. In conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia.
Dosimetry and Quality Control in Electron Beam Processing (1979)

Accurate dosimetry measurements are essential to the maximum success of commercial application of radiation processing. Such dosimetry must be involved in three different areas to assure proper final quality in the processing program. These are; 1) dosimetry related to the basic research on the radiation process involved, 2) dosimetric calibration of the radiation facility at the time of its commissioning and each major modification, and 3) radiation monitoring of the routine production process. Although careful attention is usually given to the first area and sometimes the second, the third area is often given too little importance. The research on a given radiation process should include, as a minimum, the measurement of such radiation quantities as absorbed dose, dose rate, apd dose distribution in the material. The facility calibration should define the complete radiation field characteristics such as radiation type, energy, dose rates, geometric distributions, and depth dose profiles for typical materials. The quality assurance monitoring of the production process should include measurement of the appropriate radiation quantities as well as operational parameters like dwell time, conveyor speed, etc. In particular, where the safety of the product is dependent upon the absorbed dose, such as in sterilization or food preservation, dosimetric monitoring is of vital importance. Quality assurance of the production process can be maintained by monitoring the radiation beam or field; or by measurement of the absorbed dose in the product; or by product testing after processing.
O Controle Interno na Administração Pública (2013)

RESUMO A administracao publica e o instrumento de acao do governo e suas atividades tem como objetivo, em todos os niveis e modalidades, o desenvolvimento social e a melhoria da qualidade de vida da coletividade. Para desempenhar o seu papel e imprescindivel que a Administracao Publica disponha de recursos financeiros suficientes e, tambem, de mecanismos de controle interno que assegurem aos gestores e a sociedade alcancar as metas previstas. Este trabalho tem como objetivo apresentar uma sintese do papel do controle interno das entidades publicas na gestao dos gastos publicos. Pretende-se ainda apresentar o conceito de controle interno e seus principais aspectos legais, especialmente aqueles contidos na Constituicao Federal, na Lei 4.320/64 e na Lei Complementar no 101/2000, assim como o seu papel na esfera da administracao publica estadual. Palavras-chave : Controle Interno. Administracao Publica. Gastos Publicos. ABSTRACT The public administration is the instrument of government action and its activities aim at the social development and the improvement of the life quality of the collectivity in all levels and modalities.  In order to play its role it is essential that the public administration has sufficient financial resources as well as internal control mechanisms to insure that the managers and society achieve the established targets. The goal of this paper is to present a summary of the internal control role of public authorities in the public expenditure management.It is thus intended to introduce the concept of internal control and its main legal aspects, especially those found in the Federal Constitution with the Law no. 4.320 /64 and in the Complementary Law no. 101/2000 as well as its role in the sphere of public state administration. Key words : Internal Control.  Public Administration.  Public expenditure.
A Study of Perpendicular Magnetic Recording Media With an Exchange Control Layer (2008)

Exchange coupled composite (ECC) media have been proposed as a way to facilitate writing of perpendicular media to allow use of magnetic materials with higher magnetic anisotropy ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ku</i> ) to increase media thermal stability. This paper is an experimental study of ECC media. Our results show that overwrite (OW) of perpendicular media can be improved significantly by the addition of an exchange control layer (ECL), consistent with the original ECC media design proposal. However, such OW improvement can also be achieved with non-ECC media (without ECL) by thickening of the cap magnetic layer. We observe that at similar OW, the non-ECC media can have similar magnetic core width (MCW) to ECC media with even higher thermal decay energy barrier ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ku</i> V/kT). The advantage of the ECC media is, instead, media signal-to-noise ratio increase over the non-ECC media. It is also observed that magnetic property and recording performance of the ECC media strongly depend on the magnetic properties and thicknesses of both ECL and cap magnetic layer.
On the Curriculum of Mathematics (1910)

The student must thoroughly understand the meaning and the philosophy, so to speak, of each mathematical concept presented to him. It takes a long time before he familiarizes himself so thoroughly with the conceptions of any mathematical subject so that he gets their significance, meaning and spirit, and the ability and facility to apply them readily. Few students have a clear understanding of the quantitative meaning and significance of the theorems of proportion, such as: “A line drawn parallel to a side of a triangle divides the other sides proportionally,” or, “Similar triangles are to each other as the squares of the homologous sides.” In all my experience I have not received from a pupil a satisfactory explanation of the truth that one divided by infinity is equal to zero, a conception used in secondary mathematics. The same is true of college mathematics. Few students who have studied Analytical Geometry are able to give the true meaning, for instance, of the equation of the straight line, y = sx + m , i . e ., that the ordinate of any point of the straight line is m greater than s times the abscissa of the point. These instances may be multiplied to quite an extent.
Sertoli cells synthesize and secrete transferrin-like protein. (1980)

One of the major proteins secreted by Sertoli cells (Band 3) has a molecular weight on sodium dodecyl sulfate-polyacrylamide gels which corresponds to rat serum transferrin. The preparation of Sertoli cell-secreted proteins contains an iron-binding protein with electrophoretic properties on native polyacrylamide gels similar to serum transferrin. Antibodies against Sertoli cell-secreted proteins contain a component which will immunoprecipitate serum transferrin. Antibodies to serum transferrin cross-react with and immunoprecipitate a major component (Band 3) of [35S]-methionine-labeled Sertoli cell-secreted proteins. We propose that testicular transferrin is a major secretory product of Sertoli cells in culture. In addition to transferrin, antiserum to rat serum proteins will immunoprecipitate one other polypeptide from preparations of Sertoli cell-secreted proteins.
SET Fault Injection Methods in Analog Circuits: Case Study (2008)

Abstract — Fault injection techniques have been proposed recently to early analyze the dependability characteristics of analog circuits. The aim of this paper is to compare SPICE level and high level analyses for SET-like faults injections on a PLL mixed analog-digital circuit. Advantages and drawbacks will be discussed, as well as the accuracy of the high level modeling with respect to low level effects of transients due for example to energetic particle hits. I.
A 120-W X-band spatially combined solid-state amplifier (1999)

In this paper, we present new results in the development of a broad-band spatial power-combining system implemented in a standard X-band waveguide environment. Using 24 off-the-shelf GaAs monolithic-microwave integrated-circuit (MMIC) power amplifiers integrated with tapered-slot antenna arrays, the new combining circuit produced up to 126-W maximum power output with a gain variation of /spl plusmn/1.9 dB within the band of interest (8-11 GHz). This hybrid circuit combiner is transparent to the device technology, and also provides an excellent heat-sinking capacity, sustaining as much as 415 W of dc power consumed by the MMIC amplifiers. The modular architecture allows easy maintenance, variable output power level, and modular assembly. Results on graceful degradation are also presented, showing superb tolerance to device failure.
Multi-core Technology -- Next Evolution Step in Safety Critical Systems for Industrial Applications? (2010)

Multi-core technology can provide valuable benefits for improving safety critical embedded systems. Examples range from multiple core architectures, introducing system redundancy, asymmetric multiprocessing allowing high software diversity, to hyper visors reducing system complexity. Can these benefits be taken for granted without considering the drawbacks and effects that come with them? The move to multi-core based architectures is already underway. Sooner, rather than later, we are forced to discover and resolve its issues for safety related applications. This paper is an attempt to evaluate the value of multi-core for safety critical systems on a broader level.