gebhart/patrepeval huggingface dataset:
Are Educational Outcomes Relevant to Environmental Education Addressed by Primary School Teachers? (1997)

Abstract Concern exists over the extent to which environmental education is being addressed in Australian primary school curricula. This is especially so since the release of the nationally developed Statements and Profiles in eight key areas of learning because no documents specifically relating to environmental education were produced. This paper reports the results of a study in which a survey based on outcomes relevant to environmental education, as drawn from curriculum documents in use in the Australian states of New South Wales and Victoria, was completed by a sample of primary teachers from both states. Results indicated that, in most schools, outcomes relevant to environmental education were being given significant attention. However, the extent to which different outcomes were addressed varied widely, as did the extent to which individual schools addressed outcomes over the years kindergarten/preparatory to year 6 (K/P-6). Implications for teacher education drawn from the findings are discussed.
The Treatment of Detrusor Incontinence by Electrical Stimulation (1979)

Cystometrograms were done on 20 patients before and during transrectal stimulation to determine if electrical stimulation increased the detrusor reflex threshold. In 4 patients the detrusor reflex threshold was increased during stimulation and urinary continence was restored. However, each patient became incontinent when transrectal stimulation was discontinued for 1 to 5 days. Thus, cyclic periods of stimulation were necessary to maintain the beneficial effects of electrical stimulation and a permanent pelvic floor stimulator was implanted since chronic transrectal stimulation was inconvenient.
John Gardiner's imitations of Gray's Odes (1950)

John Gardiner's imitations of Gray's Odes Get access Herbert W. Starr Herbert W. Starr Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CXCV, Issue nov25, 25 November 1950, Pages 520–521, https://doi.org/10.1093/nq/CXCV.nov25.520 Published: 25 November 1950
Therapeutic Monitoring of Rapamycin (1993)

Rapamycin (RAPA) is a new immunosuppressive drug with a potency similar to that of FK506 and up to a 100-fold greater than that of cyclosporine (CsA). RAPA has shown to be efficacious in the prolongation of allograft survival in a number of animal models. In early studies, RAPA was administered on a dose/weight basis, with little attention given to its effective blood concentration. Details describing the approaches used to establish a therapeutic range for the drug in animal transplant models are described. Guidelines for therapeutic monitoring of the drug are proposed. It is hoped that such preclinical work in animals will facilitate establishment of monitoring protocols for the drug in clinical trials.
PaperFold (2015)

In this paper, we investigate the use of shape changes in a multi-segmented mobile device for triggering viewport transformations in its graphical interface. We study PaperFold, a foldable device with reconfigurable thin-film electrophoretic display tiles. PaperFold enables users to attach, reorient and fold displays in a mobile form factor that is thin and lightweight even when fully collapsed. We discuss how our design was informed by a participatory study that resulted in 14 preferred shape changes. In a subsequent study, we asked users to rank the utility of shape changes for triggering common view operations in map and text editing applications. Results suggest participants were able to attribute specific view operations as automated responses to folding, attaching, reorienting or detaching displays. Collated or full screen views were preferred when users collocated two displays. When adding a third display, alternative views such as toolbars or a list of apps were suggested. Showing 3D views was strongly associated with folding PaperFold segments into a three dimensional structure.
The Impact of the "Wind Farm - Battery" Unit on the Power System Stability and Control (2007)

The largest disadvantage of wind power is its weather dependence, i.e. volatility. With the fast increase of the installed wind power, especially offshore, their impact on the power system operation will increase too. In order to remedy the impact of these drawbacks of the wind power, the use of batteries as power buffer has been investigated. Smoothening of the power fluctuations from large wind farms and use of batteries as primary and secondary control of the wind farm has been analysed. The connection of one "wind farm - battery" unit on a test power system has been modelled. The system with and without the use of battery has been tested. Thereat the power system stability parameters have been observed (rotor angle, voltage and frequency). Obtained results show large improvement in power system stability when using battery as a power backup of large wind farms.
Targeted Sos1 deletion reveals its critical role in early T-cell development (2011)

Activation of the small G protein Ras is required for thymocyte differentiation. In thymocytes, Ras is activated by the Ras guanine exchange factors (RasGEFs) Sos1, Sos2, and RasGRP1. We report the development of a floxed allele of sos1 to assess the role of Sos1 during thymocyte development. Sos1 was required for pre-T-cell receptor (pre-TCR)- but not TCR-stimulated developmental signals. Sos1 deletion led to a partial block at the DN-to-DP transition. Sos1-deficient thymocytes showed reduced pre-TCR-stimulated proliferation, differentiation, and ERK phosphorylation. In contrast, TCR-stimulated positive selection, and negative selection under strong stimulatory conditions, remained intact in Sos1-deficient mice. Comparison of RasGEF expression at different developmental stages showed that relative to Sos2 and RasGRP1, Sos1 is most abundant in DN thymocytes, but least abundant in DP thymocytes. These data reveal that Sos1 is uniquely positioned to affect signal transduction early in thymocyte development.
Hypermethylation of <i>APC</i> promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset  of colorectal serrated adenomas (2009)

Hypermethylation of APC promoter 1A, instead of mutations involving APC and beta-catenin, contributes to moderate activation of Wnt signalling in a subset of SAs.
Oligonucleotides containing a piperazino-modified 2′-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance (2015)

Incorporation of a piperazino-modified 2'-amino-LNA monomer (PipLNA-T) into oligonucleotides conferred very high affinity and base-pairing selectivity towards complementary DNA and RNA strands. Furthermore, one PipLNA-T modification provided a robust nuclease resistance that safeguarded three neighbouring natural nucleosides from 3'-exonucleolytic degradation. These favourable properties render PipLNA-T a promising oligonucleotide modification for various biological applications.
EPA’s role in promoting water efficiency (2009)

The Alliance for Water Efficiency is pleased to appear before you today to offer views on activities and programs to improve water efficiency throughout the United States. We are a North American non‐profit organization, composed of diverse stakeholders with significant experience in water conservation programs and policies. Our mission is to promote the efficient and sustainable use of water, to promote cost‐effective water efficiency measures that will reduce wasteful consumption, reduce the need for additional drinking water and waste water capacity, and provide multiple energy, economic, and environmental benefits. And in that mission, we work closely with staff at the Environmental Protection Agency (EPA). As the nation’s steward of ambient water quality as well as safe drinking water, EPA has promoted water efficiency’s many benefits. Programs have existed for over 20 years in EPA’s Office of Water and Wastewater, albeit modestly funded and staffed.
Diagnosing and treating pacemaker syndrome (2001)

Articles| February 01 2001 Diagnosing and treating pacemaker syndrome CJ Van Orden Wallace CJ Van Orden Wallace Search for other works by this author on: This Site PubMed Google Scholar Crit Care Nurse (2001) 21 (1): 24–31. https://doi.org/10.4037/ccn2001.21.1.24 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Cite Icon Cite Get Permissions Citation CJ Van Orden Wallace; Diagnosing and treating pacemaker syndrome. Crit Care Nurse 1 February 2001; 21 (1): 24–31. doi: https://doi.org/10.4037/ccn2001.21.1.24 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCritical Care Nurse Search Advanced Search You do not currently have access to this content.
Toleration and Recognition: What should we teach? (2010)

Generally we think it good to tolerate and to accord recognition. Yet both are complex phenomena and our teaching must acknowledge and cope with that complexity. We tolerate only what we object to, so our message to students cannot be simply, ‘promote the good and prevent the bad’. Much advocacy of toleration is not what it pretends to be. Nor is it entirely clear what sort of conduct should count as intolerant. Sometimes people are at fault for tolerating what they should not, or for tolerating what they should find unexceptionable. So virtue does not always lie with toleration. Tolerance can also seem condescending; should we therefore replace it with recognition? But recognition may not be able to coexist with the disapproval that makes toleration necessary. However, not everything about toleration and recognition is controversial; there are fixed points from which students can grapple with the issues presented by both.
Investigation of the striking characteristics of a Penning ion source (1984)

This work describes a new technique which uses the time spectrum of fast neutrons produced by the extracted ions to study the switching characteristics of a small Penning ion source. It is found that the rise and delay times of the Penning discharge decrease with the pressure and the anode voltage, and are insensitive to the magnetic field provided that the electron confinement time is much longer than the mean ionization time. A proposed model successfully explains the rise-time variations with the source operating parameters.
Two Novel Real-Time Reverse Transcriptase PCR Assays for Rapid Detection of Bacterial Contamination in Platelet Concentrates (2004)

The incidence of platelet bacterial contamination is approximately 1 per 2,000 units and has been acknowledged as the most frequent infectious risk from transfusion. In preliminary studies, the sterility of platelet concentrates (PCs) was tested with an automated bacterial blood culturing system and molecular genetic assays. Two real-time reverse transcriptase PCR (RT-PCR) assays performed in a LightCycler instrument were developed and compared regarding specificity and sensitivity by the use of different templates to detect the majority of the clinically important bacterial species in platelets. Primers and probes specific for the conserved regions of the eubacterial 23S rRNA gene or the groEL gene (encoding the 60-kDa heat shock protein Hsp60) were designed. During the development of the 23S rRNA RT-PCR, problems caused by the contamination of reagents with bacterial DNA were noted. Treatment with 8-methoxypsoralen and UV irradiation reduced the level of contaminating DNA. The sensitivity of the assays was greatly influenced by the enzyme system which was used. With rTth DNA polymerase in a one-enzyme system, we detected 500 CFU of Escherichia coli or Staphylococcus epidermidis/ml. With a two-enzyme system consisting of Moloney murine leukemia virus RT and Taq DNA polymerase, we detected 16 CFU/ml. With groEL mRNA as the target of RT-PCR under optimized conditions, we detected 125 CFU of E. coli/ml, and no problems with false-positive results caused by reagent contamination or a cross-reaction with human nucleic acids were found. Furthermore, the use of mRNA as an indicator of viability was demonstrated. Here we report the application of novel real-time RT-PCR assays for the detection of bacterial contamination of PCs that are appropriate for transfusion services.
A synthetic DNA encoding a modified human urokinase resistant to inhibition by serum plasminogen activator inhibitor (1991)

Using DNA synthesis technology we constructed two synthetic DNAs, designated syn-uPA-DNA and mut-uPA-DNA. Syn-uPA-DNA contains the complete coding sequence of human presecretion form of single-chain u-PA. Mut-uPA-DNA was derived from syn-uPA-DNA by deleting 18 base pairs coding for amino acids Arg179-Ser184. Each synthetic DNA was inserted into a bovine papilloma viral genome-based expression vector to obtain expression in mouse cells. The results indicate that both syn-uPA and mut-uPA proteins are secreted predominantly in single-chain form. The single-chain form of both enzymes can be completely converted to two-chain form by treatment with plasmin. Both enzymes are as active as natural urokinase (std-uPA) isolated from urine. Analysis of enzymatic activity indicates that under conditions where syn-uPA and std-uPA are completely inhibited by endothelial-type plasminogen activator inhibitor (PAI-1), mut-uPA retains 90% activity. In identical experiments with placental-type PAI (PAI-2), mut-uPA retains 80% activity. Syn-uPA is capable of forming a approximately 100-kDa complex with PAI, whereas mut-uPA can not. PAI-treated mut-uPA has kinetic properties similar to untreated syn-uPA or std-uPA. Overall, the data indicate that amino acids Arg179-Ser184 function at least in part as a binding site for PAI. Resistance to PAI inhibition may increase the potency of mut-uPA as a thrombolytic agent.
Electronic Structure and Mobility of Alkylated and Nonalkylated Organic Semiconductors: Role of van der Waals Interactions (2013)

We present a comparison based on first-principles calculations of the electronic structure of nonalkylated and alkylated dinaphtho[2,3-b:2',3'-f]thieno[3,2-b]thiophene: DNTT and DNTT-C10. The calculations show that the addition of alkyl chains decreases intermolecular distances, in agreement with experiments. Calculations indicate that effective masses are reduced by the addition of alkyl chains, and within a simple deformation potential model, this translates into higher mobility for DNTT-C10. The shorter intermolecular distances found in DNTT-C10 are attributed to van der Waals interactions between alkyl chains.
Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF) (1996)

Mycophenolate mofetil (MMF) is a novel immunosuppressive drug that shows promise in preventing the rejection of organ allografts and in the treatment of ongoing rejection. Orally administered MMF is hydrolyzed by esterases in the intestine and blood to release mycophenolic acid (MPA), a potent, selective, noncompetitive inhibitor of the type 2 isoform of inosine monophosphate dehydroxygenase (IMPDH) expressed in activated human T and B lymphocytes. By inhibiting IMPDH, MPA depletes the pool of dGTP required for DNA synthesis. MPA has a more potent cytostatic effect on lymphocytes than on other cell types, and this is the principal mechanism by which immunosuppressive activity is exerted. MPA also depletes pools of GTP in human lymphocytes and monocytes, thereby inhibiting the synthesis of fucose- and mannose-containing saccharide components of membrane glycoproteins. These are recognized by the family of adhesion molecules termed selectins. By this mechanism, MPA could decrease the recruitment of lymphocytes and monocytes into sites of graft rejection. In addition to preventing allograft rejection, MMF suppresses graft-versus-host reactions in lethal and nonlethal murine models. MMF inhibits primary antibody responses more efficiently than secondary responses. MPA inhibits the proliferation of human B lymphocytes transformed by Epstein-Barr virus and is not mutagenic. Clinically attainable concentrations of MPA suppress the proliferation of human arterial smooth muscle cells. These two properties of MPA may decrease the risk of lymphoma development and proliferative arteriopathy in long-term recipients of MMF.
Identification of potential influenza virus endonuclease inhibitors through virtual screening based on the 3D-QSAR model (2009)

Influenza endonucleases have appeared as an attractive target of antiviral therapy for influenza infection. With the purpose of designing a novel antiviral agent with enhanced biological activities against influenza endonuclease, a three-dimensional quantitative structure-activity relationships (3D-QSAR) model was generated based on 34 influenza endonuclease inhibitors. The comparative molecular similarity index analysis (CoMSIA) with a steric, electrostatic and hydrophobic (SEH) model showed the best correlative and predictive capability (q(2) = 0.763, r(2) = 0.969 and F = 174.785), which provided a pharmacophore composed of the electronegative moiety as well as the bulky hydrophobic group. The CoMSIA model was used as a pharmacophore query in the UNITY search of the ChemDiv compound library to give virtual active compounds. The 3D-QSAR model was then used to predict the activity of the selected compounds, which identified three compounds as the most likely inhibitor candidates.
Quantitative Proteomic Analysis of the Heat Stress Response in <i>Clostridium difficile</i> Strain 630 (2011)

Clostridium difficile is a serious nosocomial pathogen whose prevalence worldwide is increasing. Postgenomic technologies can now be deployed to develop understanding of the evolution and diversity of this important human pathogen, yet little is known about the adaptive ability of C. difficile. We used iTRAQ labeling and 2D-LC-MS/MS driven proteomics to investigate the response of C. difficile 630 to a mild, but clinically relevant, heat stress. A statistically validated list of 447 proteins to which functional roles were assigned was generated, allowing reconstruction of central metabolic pathways including glycolysis, γ-aminobutyrate metabolism, and peptidoglycan biosynthesis. Some 49 proteins were significantly modulated under heat stress: classical heat shock proteins including GroEL, GroES, DnaK, Clp proteases, and HtpG were up-regulated in addition to several stress inducible rubrerythrins and proteins associated with protein modification, such as prolyl isomerases and proline racemase. The flagellar filament protein, FliC, was down-regulated, possibly as an energy conservation measure, as was the SecA1 preprotein translocase. The up-regulation of hydrogenases and various oxidoreductases suggests that electron flux across these pools of enzymes changes under heat stress. This work represents the first comparative proteomic analysis of the heat stress response in C. difficile strain 630, complementing the existing proteomics data sets and the single microarray comparative analysis of stress response. Thus we have a benchmark proteome for this pathogen, leading to a deeper understanding of its physiology and metabolism informed by the unique functional and adaptive processes used during a temperature upshift mimicking host pyrexia.
Engineering the E. coli UDP-Glucose Synthesis Pathway for Oligosaccharide Synthesis (2006)

A metabolic engineering strategy was successfully applied to engineer the UDP-glucose synthesis pathway in E. coli. Two key enzymes of the pathway, phosphoglucomutase and UDP-glucose pyrophosphorylase, were overexpressed to increase the carbon flux toward UDP-glucose synthesis. When additional enzymes (a UDP-galactose epimerase and a galactosyltransferease) were introduced to the engineered strain, the increased flux to UDP-glucose synthesis led to an enhanced UDP-galactose derived disaccharide synthesis. Specifically, close to 20 mM UDP-galactose derived disaccharides were synthesized in the engineered strain, whereas in the control strain only 2.5 mM products were obtained, indicating that the metabolic engineering strategy was successful in channeling carbon flux (8-fold more) into the UDP-glucose synthesis pathway. UDP-sugar synthesis and oligosaccharide synthesis were shown to increase according to the enzyme expression levels when inducer concentration was between 0 and 0.5 mM. However, this dependence on the enzyme expression stopped when expression level was further increased (IPTG concentration was increased from 0.5 to 1 mM), indicating that other factors emerged as bottlenecks of the synthesis. Several likely bottlenecks and possible engineering strategies to further improve the synthesis are discussed.
A UML tool for an automatic generation of simulation programs (2000)

For sometime now, Unified Modelling Language (UML) has been accepted as a standard for designing new systems. Its array of notations helps system designers to capture their ideas in a way that is expressive yet easy to understand. One thing that UML lacks though, is a means for predicting the system's performance directly from its design. Performance prediction is a desirable feature that enables us to evaluate whether a particular design is worth implementing or not. This prediction can frequently be obtained by constructing a simulation program that mimics the characteristics of the new system. The information gathered from running the simulation will then allow us to estimate the performance. In this paper, we present a simulation framework that can be used to generate simulation programs straight from UML notations. We also present a tool has been built to demonstrate the feasibility of using this framework to perform such a transformation automatically.
Synthesis of α‐carboxy‐γ‐butyrolactones by rearrangement of <i>capto‐dative</i> cyclopropanes on silica surfaces (1982)

Abstract The rearrangement of some cyclopropanes featuring electron‐withdrawing and electron releasing substitu‐ents on vicinal carbons of the trimethylene ring to α‐carboxy‐γ‐lactones upon contact with silica gel at room temperature has been discovered. One or two alkyl ester groups were chosen as electron attractor substitu‐ents while one or two cyclopropyl units were used for the release of electron density. It was observed that the lactone forming process is strongly dependent upon these substituents to the extent that only two ester groups and at least one cyclopropane will confer enough vulnerability to the tetra‐substituted cyclopropane for the rearrangement to take place. A comparative study of the lactonization by means of contact with silica and alkaline hydrolysis was performed and some mechanistic considerations are put forth.
A serrated edge Gregorian subreflector for dual chamber compact range systems (1991)

The performance of a Gregorian subreflector compact range system is studied. The compact range system uses a cosine blended rolled edge main reflector. Thus, the main reflector edge diffraction in the potential target zone of the compact system is very small. However, it was found that the diffraction from the edges of the subreflector degrades the incident fields on the main reflector, which subsequently leads to undesired stray fields in the target zone. To reduce the subreflector edge diffraction incident on the main reflector, serrations were added to the subreflector. It is shown that by using the serrated edge reflector, one can reduce the subreflector edge diffraction incident on the main reflector, which subsequently lowers the undesired stray fields in the target zone.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>