gebhart/patrepeval huggingface dataset:
Bubble-Pen Lithography (2015)

Current lithography techniques, which employ photon, electron, or ion beams to induce chemical or physical reactions for micro/nano-fabrication, have remained challenging in patterning chemically synthesized colloidal particles, which are emerging as building blocks for functional devices. Herein, we develop a new technique - bubble-pen lithography (BPL) - to pattern colloidal particles on substrates using optically controlled microbubbles. Briefly, a single laser beam generates a microbubble at the interface of colloidal suspension and a plasmonic substrate via plasmon-enhanced photothermal effects. The microbubble captures and immobilizes the colloidal particles on the substrate through coordinated actions of Marangoni convection, surface tension, gas pressure, and substrate adhesion. Through directing the laser beam to move the microbubble, we create arbitrary single-particle patterns and particle assemblies with different resolutions and architectures. Furthermore, we have applied BPL to pattern CdSe/ZnS quantum dots on plasmonic substrates and polystyrene (PS) microparticles on two-dimensional (2D) atomic-layer materials. With the low-power operation, arbitrary patterning and applicability to general colloidal particles, BPL will find a wide range of applications in microelectronics, nanophotonics, and nanomedicine.
Field Studies on Ozone Inactivation of a<u>Gymnodinium Breve</u>Toxin (1975)

Water samples were collected from Boca Ciega Bay (St. Petersburg) during the April, 1974, red tide that occurred on the Florida west coast. The causative agent of this phenomenon was the toxic dinoflagellate, Gymnodinium breve. The toxic red tide samples were treated with ozone gas and rendered nonlethal, as measured by mouse injection.
Potential benefits of cool roofs on commercial buildings: conserving energy, saving money, and reducing emission of greenhouse gases and air pollutants (2009)

Cool roofs—roofs that stay cool in the sun by minimizing solar absorption and maximizing thermal emission—lessen the flow of heat from the roof into the building, reducing the need for space cooling energy in conditioned buildings. Cool roofs may also increase the need for heating energy in cold climates. For a commercial building, the decrease in annual cooling load is typically much greater than the increase in annual heating load. This study combines building energy simulations, local energy prices, local electricity emission factors, and local estimates of building density to characterize local, state average, and national average cooling energy savings, heating energy penalties, energy cost savings, and emission reductions per unit conditioned roof area. The annual heating and cooling energy uses of four commercial building prototypes—new office (1980+), old office (pre-1980), new retail (1980+), and old retail (pre-1980)—were simulated in 236 US cities. Substituting a weathered cool white roof (solar reflectance 0.55) for a weathered conventional gray roof (solar reflectance 0.20) yielded annually a cooling energy saving per unit conditioned roof area ranging from 3.30 kWh/m2 in Alaska to 7.69 kWh/m2 in Arizona (5.02 kWh/m2 nationwide); a heating energy penalty ranging from 0.003 therm/m2 in Hawaii to 0.14 therm/m2 in Wyoming (0.065 therm/m2 nationwide); and an energy cost saving ranging from 0.126/m2 in West Virginia to 1.14/m2 in Arizona ( 0.356/m2 nationwide). It also offered annually a CO2 reduction ranging from 1.07 kg/m2 in Alaska to 4.97 kg/m2 in Hawaii (3.02 kg/m2 nationwide); an NOx reduction ranging from 1.70 g/m2 in New York to 11.7 g/m2 in Hawaii (4.81 g/m2 nationwide); an SO2 reduction ranging from 1.79 g/m2 in California to 26.1 g/m2 in Alabama (12.4 g/m2 nationwide); and an Hg reduction ranging from 1.08 μg/m2 in Alaska to 105 μg/m2 in Alabama (61.2 μg/m2 nationwide). Retrofitting 80% of the 2.58 billion square meters of commercial building conditioned roof area in the USA would yield an annual cooling energy saving of 10.4 TWh; an annual heating energy penalty of 133 million therms; and an annual energy cost saving of 735 million. It would also offer an annual CO2 reduction of 6.23 Mt, offsetting the annual CO2 emissions of 1.20 million typical cars or 25.4 typical peak power plants; an annual NOx reduction of 9.93 kt, offsetting the annual NOx emissions of 0.57 million cars or 65.7 peak power plants; an annual SO2 reduction of 25.6 kt, offsetting the annual SO2 emissions of 815 peak power plants; and an annual Hg reduction of 126 kg.
Data Management in the Cloud: Limitations and Opportunities. (2009)

Recently the cloud computing paradigm has been receiving significant excitement and attention in the media and blogosphere. To some, cloud computing seems to be little more than a marketing umbrella, encompassing topics such as distributed computing, grid computing, utility computing, and softwareas-a-service, that have already received significant research focus and commercial implementation. Nonetheless, there exist an increasing number of large companies that are offering cloud computing infrastructure products and services that do not entirely resemble the visions of these individual compo-
Inhibitors Alter the Stochasticity of Regulatory Proteins to Force Cells to Switch to the Other State in the Bistable System (2017)

The cellular behaviors under the control of genetic circuits are subject to stochastic fluctuations, or noise. The stochasticity in gene regulation, far from a nuisance, has been gradually appreciated for its unusual function in cellular activities. In this work, with Chemical Master Equation (CME), we discovered that the addition of inhibitors altered the stochasticity of regulatory proteins. For a bistable system of a mutually inhibitory network, such a change of noise led to the migration of cells in the bimodal distribution. We proposed that the consumption of regulatory protein caused by the addition of inhibitor is not the only reason for pushing cells to the specific state; the change of the intracellular stochasticity is also the main cause for the redistribution. For the level of the inhibitor capable of driving 99% of cells, if there is no consumption of regulatory protein, 88% of cells were guided to the specific state. It implied that cells were pushed, by the inhibitor, to the specific state due to the change of stochasticity.
<i>AVR1-CO39</i> Is a Predominant Locus Governing the Broad Avirulence of <i>Magnaporthe oryzae</i> 2539 on Cultivated Rice (<i>Oryza sativa</i> L.) (2010)

Magnaporthe oryzae 2539 was previously found to be avirulent to most rice cultivars and, therefore, was assumed to carry many avirulence (AVR) genes. However, only one AVR gene, AVR1-CO39, which corresponds to a resistance (R) gene Pi-CO39(t) in rice cv. CO39, has been found from 2539 thus far. In order to identify more AVR genes, we isolated 228 progeny strains from a cross between 2539 and Guy11, an M. oryzae strain with strong virulence on rice, and inoculated these strains onto 23 rice accessions (22 individual cultivars and a mixture of 14 cultivars) that are all resistant to 2539 but susceptible to Guy11. Unexpectedly, the experimental results indicated that the avirulence of 2539 on these rice cultivars appeared to be controlled only by the AVR1-CO39 locus. Consistent with this result, we further found that all except one of the rice cultivars were resistant to two transformed Guy11 strains carrying a 1.05-kb fragment containing the AVR1-CO39 gene from 2539. These results suggest that AVR1-CO39 is a predominant locus controlling the broad avirulence of 2539 on cultivated rice. Based on the results of this study and other previous studies, we infer that AVR1-CO39 is a species-wise rather than a cultivar-wise host-specific AVR locus of M. oryzae for rice.
Residual Stress Measurement in Circular Steel Cylinders (1983)

Abstract : Hoop residual stresses in a right circular steel cylinder were determined by ultrasonic velocity measurements. The zero stress position was obtained from an equilibrium condition, setting the integrated tensile equal to the integrated compressive hoop stress. Absolute stress values were obtained with the help of calibration measurements on a rectangular test bar of the same material, which was subjected to known applied forces. The stresses determined from these ultrasonic velocity measurements are in good agreement with values obtained by x-ray diffraction analysis of lattice strains.
Fast Motion Planning for Agile Space Systems with Multiple Obstacles (2016)

In this paper, we develop a novel algorithm for spacecraft trajectory planning in an environment cluttered with many geometrically-fixed obstacles. The Spherical Expansion and Sequential Convex Programming (SE-SCP) algorithm first uses a spherical-expansion-based sampling algorithm to explore the workspace. Once a path is found from the start position to the goal position, the algorithm generates a locally optimal trajectory within the homotopy class using sequential convex programming. If the number of samples tends to infinity, then the SE-SCP trajectory converges to the globally optimal trajectory in the workspace. The SE-SCP algorithm is computationally efficient, therefore it can be used for real-time applications on resource-constrained systems. We also present results of numerical simulations and comparisons with existing algorithms.
Using a covered stent for large cerebral aneurysms treated with stent-assisted coiling (2015)

Endovascular reconstruction combining a covered stent with stent-assisted coiling could be an effective and safe strategy for the treatment of large cerebral aneurysms.
Differential dependency network analysis to identify condition-specific topological changes in biological networks (2008)

The DDN MATLAB toolbox and experiment data are available at http://www.cbil.ece.vt.edu/software.htm.
Patterns of dispersion, density and dispersal in alpine populations of the land snail Arianta arbustorum (L.) (Helicidae) (1986)

In studying populations of the land snail Arianta arbustorum in the eastern Swiss Alps, juvenile and subadult snails were found to be aggregated all the time, while adults were mostly aggregated during summer, the main mating period. The mean size of aggregations was 25 cm × 25 cm but varied, according to the area a grass tuft covered, while the intensity of aggregations was influenced by weather conditions. Densities of 10–15 subadults and 3–6 adults m −2 were found along ditches and streams, 2–25 subadults and 2–20 adults on uncultivated alpine meadows, while on scree‐covered alpine grassland the density of subadults and adults was 0.3–0.5 m −2 . The extent of daily movements varied with microclimatic factors and season and depended on the structure of the habitat. The dispersal rate was greatest in June (2.6 m month −1 ) and least in August (1.1 m month −1 ). In summer and autumn, active uphill movements were noted, a process which compensates for the loss of altitude by passive downhill displacements. Roiling down on snowfields and being carried away by avalanches and streams were observed.
Bone loss from the proximal femur after arthroplasty with an isoelastic femoral stem:BMD measurements in 25 patients after 9 years (1995)

To quantify the bone loss from the proximal femur after total hip arthroplasty with an isoelastic femoral stem, the bone mineral densities (BMD) around 25 such stems were measured after an 8.5 (7.5-9.5)-year follow-up. The contralateral, healthy side was used as a control. The BMD on the prosthesis side was lower by a mean of 14 percent than on the control side. The difference was greatest in the calcar area and smallest in the cortex medially of the prosthesis stem. The decreases in BMD around the metaphyseal and diaphyseal areas of the stem were smaller than those reported for stiff stems. The marked bone loss in the calcar region is possibly due to stress bypass-i.e., the axial load is transmitted directly into the metaphyseal area of the femoral shaft, causing an increase in its stiffness and in the jamming of the prosthesis stem.
Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases (2019)

Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecular targets, protease-activated receptors (PARs) are abundantly recognized for their roles in the development of chronic inflammatory diseases. In particular, several inflammatory effects are directly mediated by the sensing of proteolytic activity by PARs. PARs belong to the seven transmembrane domain G protein-coupled receptor family, but are unique in their lack of physiologically soluble ligands. In contrast with classical receptors, PARs are activated by N-terminal proteolytic cleavage. Upon removal of specific N-terminal peptides, the resulting N-termini serve as tethered activation ligands that interact with the extracellular loop 2 domain and initiate receptor signaling. In the classical pathway, activated receptors mediate signaling by recruiting G proteins. However, activation of PARs alternatively lead to the transactivation of and signaling through receptors such as co-localized PARs, ion channels, and toll-like receptors. In this review we consider PARs and their modulators as potential therapeutic agents, and summarize the current understanding of PAR functions from clinical and in vitro studies of PAR-related inflammation.
O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma (2014)

MGMT activity is an attractive target for anti-resistance therapy regardless of methylation status.
Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement. (1985)

Cigarette smoking is associated with significant increases in the number of pulmonary mononuclear phagocytes and neutrophils. A potent chemoattractant for these cells is C5a, a peptide generated during complement (C) activation. We, therefore, investigated the possibility that cigarette smoke could activate the complement system in vitro. Our results show that factor(s) (mol wt less than 1,000) present in an aqueous solution of whole, unfiltered cigarette smoke can deplete the hemolytic capacity of whole human serum in a dose-dependent manner. The particle-free, filtered gas phase of cigarette smoke is inactive. The smoke factor(s) do not activate serum C1, but do deplete serum C4 activity. Treatment of purified human C3 with whole smoke solution modifies the molecule such that its subsequent addition to serum (containing Mg/EGTA to block the classical pathway) results in consumption of hemolytic complement by activation of the alternative pathway. Smoke-modified C3 shows increased anodal migration in agarose electrophoresis, but this is not due to proteolytic cleavage of the molecule as evidenced by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In contrast to methylamine-treated C3, C3 treated with smoke is only partially susceptible to the action of the complement regulatory proteins Factors H and I. In addition, smoke-modified C3 has diminished binding to Factor H as compared with methylamine-treated C3. Finally, smoke-modified C3 incorporates [14C]methylamine which suggests that the thiolester bond may be intact. These data indicate that aqueous whole cigarette smoke solution can modify C3 and activate the alternative pathway of complement, perhaps by a previously unrecognized mechanism. Should this occur in vivo, complement activation might partly account for the extensive pulmonary leukocyte recruitment observed in smokers.
Speech in Noisy Environments: robust automatic segmentation, feature extraction, and hypothesis combination (2002)

The first evaluation for Speech in Noisy Environments (SPINE1) was conducted by the Naval Research Labs (NRL) in August, 2000. The purpose of the evaluation was to test existing core speech recognition technologies for speech in the presence of varying types and levels of noise. In this case the noises were taken from military settings. Among the strategies used by Carnegie Mellon University's successful systems designed for this task were session-adaptive segmentation, robust mel-scale filtering for the computation of cepstra, the use of parallel front-end features and noise-compensation algorithms, and parallel hypotheses combination through word-graphs. This paper describes the motivations behind the design decisions taken for these components, supported by observations and experiments.
Indirect Matrix Converter for Hybrid Electric Vehicle Application with Three-Phase and Single-Phase Outputs (2015)

This paper presents an indirect matrix converter (IMC) topology for hybrid electric vehicle (HEV) application with three-phase and single-phase outputs. The HEV includes mechanical, electrical, control, and electrochemical systems among others. In the mechanical system, a traction motor and a compressor motor are used to drive the HEV. The traction motor and the compressor motor are usually operated as three-phase and single-phase motors, respectively. In this respect, a dual AC-drive system can operate the traction and the compressor motor simultaneously. Furthermore, compared to a conventional dual matrix converter system, the proposed topology can reduce the number of switches that the dual outputs share with a DC-link. The application of this system for HEV has advantages, like long lifetime and reduced volume due to the lack of a DC-link. The proposed control strategy and modulation schemes ensure the sinusoidal input and output waveforms and bidirectional power transmission. The proposed system for the HEV application is verified by simulation and experiments.
Extrapyramidal Reactions and the Selective Serotonin-Reuptake Inhibitors (1997)

The use of SSRIs may be associated with the development of EPRs; therefore, appropriate monitoring should be considered for patients so that optimal pharmaceutical care may be provided.
Automatic extraction of road intersections from raster maps (2005)

Numerous raster maps are available on the Internet, but the geographic coordinates of the maps are often unknown. In order to determine the precise location of a raster map, we exploit the fact that the layout of the road intersections within a certain area can be used to determine the map's location. In this paper, we describe an approach to automatically extract road intersections from arbitrary raster maps. Identifying the road intersections is difficult because raster maps typically contain multiple layers that represent roads, buildings, symbols, street names, or even contour lines, and the road layer needs to be automatically separated from other layers before road intersections can be extracted. We combine a variety of image processing and graphics recognition methods to automatically eliminate the other layers and then extract the road intersection points. During the extraction process, we determine the intersection connectivity (i.e., number of roads that meet at an intersection) and the road orientations. This information helps in matching the extracted intersections with intersections from known sources (e.g., vector data or satellite imagery). For the problem of road intersection extraction, we applied the techniques to a set of 48 randomly selected raster maps from various sources and achieved over 90% precision with over 75% recall. These results are sufficient to automatically align raster maps with other geographic sources, which makes it possible to determine the precise coverage and scale of the raster maps.
Differential Excretion of Leucocyte Granule Components in Inflammatory Bowel Disease: Implications for Pathogenesis (1997)

1. Faecal excretion of the leucocyte primary granule component, myeloperoxidase, and of the secondary granule component, lactoferrin, were compared in inflammatory bowel disease and infective diarrhoea. 2. Faecal lactoferrin correlated with faecal myeloperoxidase in both inflammatory bowel disease (P = 0.0018; n = 32) and infective diarrhoea (P = 0.00013; n = 37), but inflammatory bowel disease was associated with a much higher faecal excretion of lactoferrin but lower excretion of myeloperoxidase than infective diarrhoea. As a consequence, the median ratio of lactoferrin/myeloperoxidase excretion (both expressed as ng/mg of protein) for inflammatory bowel disease was 7.5 (range 3.5-21.3) with similar values for ulcerative colitis (n = 18) and Crohn's disease (n = 14) compared with only 0.9 (range 0.4-2.3; P < 0.0001) for infective diarrhoea. In inflammatory bowel disease faecal lactoferrin and myeloperoxidase excretion remained increased even in clinical remission. 3. In subsequent immunohistochemical studies to assess the possible explanation for these findings, lactoferrin and myeloperoxidase were demonstrated within crypt abscesses and surface mucus, both in inflammatory bowel and in infective diarrhoea mucosal samples. There was a slight increase in the number of lactoferrin-containing cells in the mucosal samples from ulcerative colitis and in the submucosa of samples from Crohn's disease compared with infective diarrhoea, but these changes were not sufficient to account for the marked increase in faecal lactoferrin excretion in inflammatory bowel disease. 4. In all mucosal samples, including those from normal mucosa, lactoferrin was also shown to be contained within mast cells. 5. These results could best be explained by a different mechanism for leucocyte activation in inflammatory bowel disease compared with infective diarrhoea, and are compatible with selective secretion of secondary granule components, which include lactoferrin but not myeloperoxidase, as a result of leucocyte activation by N-formylated bacterial peptides in inflammatory bowel disease.
Annular surfaces in annular field systems (1997)

We present an optical surface description that is more suit- able for designing annular field systems than the standard aspheric sur- face representation. The use of this novel surface description leads to shorter design times and improved systems. © 1997 Society of Photo-Optical Instrumentation Engineers. (S0091-3286(97)01812-6)
Demo hour (2014)

Interactivity is a unique forum of the ACM CHI Conference that showcases hands-on demonstrations, novel interactive technologies, and artistic installations. At CHI 2014, we aimed to create a "one of a CHInd" Interactivity experience with more than 60 interactive exhibits to highlight the diverse group of computer scientists, sociologists, designers, psychologists, artists, and many more that make up the CHI community. Julie Rico Williamson and Steven Benford, CHI Interactivity Chairs
Transcription Initiation-Defective Forms of ς <sup>54</sup> That Differ in Ability To Function with a Heteroduplex DNA Template (2000)

Transcription by sigma(54)-RNA polymerase holoenzyme requires an activator that catalyzes isomerization of the closed promoter complex to an open complex. We examined mutant forms of Salmonella enterica serovar Typhimurium sigma(54) that were defective in transcription initiation but retained core RNA polymerase- and promoter-binding activities. Four of the mutant proteins allowed activator-independent transcription from a heteroduplex DNA template. One of these mutant proteins, L124P V148A, had substitutions in a sequence that had not been shown previously to participate in the prevention of activator-independent transcription. The remaining mutants did not allow efficient activator-independent transcription from the heteroduplex DNA template and had substitutions within a conserved 20-amino-acid segment (Leu-179 to Leu-199), suggesting a role for this sequence in transcription initiation.