gebhart/patrepeval huggingface dataset:
Integration of multi-standard front end modules SOCs on high resistivity SOI RF CMOS technology (2010)

RF front end modules (FEMs) are currently realized using a variety of technologies. However, since integration drives wireless business in order to achieve the appropriate cost and form factor, we see significant research concerning FEM integration on silicon. In this quest, SOI technology has already addressed two key blocks, the antenna switch and the power amplifier. In this paper, we will focus our investigation on high performance passive functions in order to demonstrate the capability of SOI CMOS technology to integrate the whole FEM. To do so, balun, harmonic filter, diplexer and directional coupler have been achieved in a 130 nm SOI CMOS technology. Measured performances are clearly competitive with most commercially available Integrated Passive Device (IPD) solutions, which paves the way of FEM silicon SOCs.
Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging (2017)

Copper-64 is a useful radioisotope for positron emission tomography (PET). Due to the wide range of applications, the demand of <sup>64</sup>Cu with low metallic impurities is increasing. Here we report a simple method for the efficient production of high specific activity <sup>64</sup>Cu using a cyclotron for biomedical application. We designed new equipment based on the plating of enriched <sup>64</sup>Ni as the target, and used automated ion exchange chromatography to purify copper-64 efficiently after irradiation and dissolution of the target in good radiochemical and chemical yield and purity. The <sup>64</sup>Cu radionuclide produced using 99.32% enriched <sup>64</sup>Ni with a density of 61.4 ± 5.0 mg/cm², reaching a total radioactivity greater than 200 mCi, with specific activity up to 5.6 GBq/μmoL. It was further incorporated into modified monoclonal antibody DOTA-rituximab to synthesize <sup>64</sup>Cu-DOTA-rituximab, which was used successfully for micro-PET imaging.
Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)-Carissone (2008)

A catalytic enantioselective approach to the eudesmane sesquiterpenoids is reported. The strategic use of a palladium-catalyzed enantioselective alkylation of vinylogous ester substrates forged the C(10) all-carbon quaternary center. This key transformation enabled a diastereoselective olefin hydrogenation to create the syn stereochemistry at C(7). The devised synthetic strategy allowed for the preparation of the antibacterial agent (+)-carissone and a formal synthesis of the P/Q-type calcium channel blocker (-)-alpha-eudesmol.
Ligands of Peroxisome Proliferator-activated Receptor Inhibit Homocysteine induced DNA Methylation of Inducible Nitric Oxide Synthase Gene (2007)

Homocysteine (Hcy) is a risk factor for atherosclerosis. It is generally accepted that inducible nitric oxide synthase (iNOS) is a key enzyme in the regulation of vascular disease. The aim of the present study is to investigate the effects of peroxisome proliferator-activated receptor ligands on iNOS in the presence of Hcy in human monocytes. Foam cells, induced by oxidize low density lipoprotein (ox-LDL) and phorbol myristate acetate (PMA) in the presence of different concentrations of Hcy, clofibrate and pioglitazone in human monocytes for 4 d, were examined by oil red O staining. The activity of iNOS was detected by real-time quantitative reverse transcription-polymerase chain reaction and Western blot analysis. The capability of DNA methylation was measured by assaying endogenous C5 DNA methyltransferase (C5MTase) activity, and the iNOS promoter methylation level was determined by quantitative MethyLight assays. The results indicated that Hcy increased the activity of C5MTase and the level of iNOS gene DNA methylation, resulting in a decrease of iNOS expression. Clofibrate and pioglitazone could antagonize the hcy effect on iNOS expression through DNA methylation, resulting in attenuation of iNOS transcription. These findings suggested that Hcy decreased the expression of iNOS by elevating iNOS DNA methylation levels, which can repress the transcription of some genes. Peroxisome proliferator-activated receptor alpha/gamma ligands can down-regulate iNOS DNA methylation, and could be useful for preventing Hcy-induced atherosclerosis by repressing iNOS expression.
Label-free bioaffinity detection using terahertz technology (2002)

We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 microg cm(-2) of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation.
Mikrowellen‐unterstützte Synthese lumineszierender LaPO<sub>4</sub>:Ce,Tb‐Nanokristalle in ionischen Flüssigkeiten (2006)

Leuchtkristalle: Ein neues Synthesekonzept besteht aus einer Mikrowellen-unterstützten Synthese stark lumineszierender und dispergierbarer LaPO4:Ce,Tb-Nanokristalle in ionischen Flüssigkeiten. Das Bild zeigt die transparente Dispersion redispergierter Nanokristalle an Tageslicht (A) und unter UV-Anregung (B). Die Oberflächenausstattung kann unabhängig von der Synthese eingestellt werden.
A Ti:LiNbO/sub 3/ optical intensity modulator with more than 20 GHz bandwidth and 5.2 V driving voltage (1991)

A broadband and low driving-voltage Ti:LiNbO/sub 3/ optical intensity modulator is described. A coplanar waveguide with a shielding plane is used for optical-electrical velocity matching and a confined waveguide is used for lowering the driving voltage. The relationship between the mode size of the guided wave and the driving voltage is shown. This modulator has an electrical 3-dB bandwidth of more than 20 GHz and a driving voltage of 5.2 V at a wavelength of 1.5 mu m.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
2. Persistence of Equine Herpesviruses in Experimentally Infected Horses and the Experimental Induction of Abortion (1970)

Summary An 8‐month‐old filly (No. 2) developed an acute vulvo‐vaginitis and respiratory disease following inoculation of equine herpesvirus (EH virus) type 1 (EH 39 virus; equine rhinopneumonitis virus) into the vestibule of the vagina. The same virus produced acute respiratory disease but not balanoposthitis following intranasal, intravenous and intrapreputial inoculation of a 12‐month‐old colt (No. 3). A second 8‐month‐old filly (No. 1) developed a mild respiratory disease but not vulvo‐vaginitis following intravestibular inoculation of EH 39 virus. EH viruses that were slowly cytopathic for equine foetal kidney cell cultures and serologically unrelated to the inoculated EH 39 virus were isolated from the buffy coat cells at 3 days and from the nasal cavity at 6 days after inoculation of horse No. 1. EH virus that was slowly cytopathic and serologically unrelated to EH 39 virus was isolated at 16 days from the vagina of the filly (No. 2) that developed acute vulvovaginitis and was frequently isolated from the nasal cavities of 2 of the 3 horses for 83 days and from the nasal cavity of the third horse for 57 days under conditions that precluded reinfection from other equidae except from each other. EH viruses were recovered from the 3 horses for a further 58 days under conditions where contact with other equidae may, although was not known to, have occurred between 83 and 141 days postinoculation. It was concluded that these viruses represented a single virus type that was present in the nasal cavity (designated EH 1–6 virus) perhaps also the blood stream of filly No. 1 at the time the 3 horses were purchased and that this virus was subsequently transmitted to the vagina of 1 and the nasal cavities of the other 2 horses. Accordingly a carrier state for EH 39 virus was not shown to occur. These findings are discussed in relation to the natural history of EH virus infections. Attempts to reactivate the EH viruses to cause clinical respiratory disease, by a series of injections of adrenalin and cortisone, were inconclusive. The 3 horses showed no clinical evidence of respiratory disease when they were reinfected intranasally with EH 39 virus 360 days (1 horse) and 412 days (2 horses) after the initial infection with this virus. Abortion was produced when EH 39 virus was inoculated directly into the allantoic or amniotic cavity of a pregnant mare although naturally occurring EH virus abortion remains unrecognised in Australia.
Purification and some chemical and physical properties of staphylococcal enterotoxin A (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPurification and some chemical and physical properties of staphylococcal enterotoxin AEdward J. Schantz, William G. Roessler, Margy J. Woodburn, Joseph M. Lynch, Henry M. Jacoby, Sidney J. Silverman, Joseph C. Gorman, and Leonard SperoCite this: Biochemistry 1972, 11, 3, 360–366Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/bi00753a009https://doi.org/10.1021/bi00753a009research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nitrogen—Total (1982)

The determination of total nitrogen (N) in soils and other complex heterogeneous materials containing several forms of N presents many difficulties. Total N analysis of soils is further complicated by the inadequacy of knowledge concerning the forms of N present and by the low N content of the material under analysis. The Kjeldahl procedures generally employed for determination of total N involve two steps: digestion of the sample to convert organic N to NH4 +-N and determination of NH4 +-N in the digest. Soil samples to be analyzed for total N are usually dried, ground, and sieved before analysis, and they are often stored for analysis in paper bags or other containers that are not airtight. Although various methods have been proposed for direct determination of NH4 + in Kjeldahl digests, this determination is usually performed by estimation of the NH3 liberated by distillation of the digest with strong alkali.
Similar normalized Emax and O2 consumption-pressure-volume area relation in rabbit and dog (1988)

The end-systolic pressure-volume relation (ESPVR), a measure of ventricular contractile state, and systolic pressure-volume area (PVA), a primary determinant of cardiac oxygen consumption per beat (VO2), have been derived from the pressure-volume diagram of the cross-circulated dog left ventricle. The slope of the PVA-VO2 relation represents the efficiency of chemomechanical energy transduction of the contractile machinery. To see whether these relationships were similar in other animals, we studied the isovolumic ESPVR and the VO2-PVA relation in nine excised, cross-circulated rabbit left ventricles. The base-line ESPVR was linear (r = 0.94-0.99) with the slope (Emax) and volume-axis intercept (V0) equal to 83.4 +/- 18.3 mmHg/ml and 0.43 +/- 0.17 ml, respectively. When normalized for left ventricular weight, Emax (4.1 +/- 1.1 mmHg.ml-1.100 g) and V0 (8.9 +/- 3.7 ml/100 g) were similar to values reported for the dog left ventricle. The correlation between PVA and VO2 was linear (r = 0.93-1.00), and the slope (1.90 X 10(-5) +/- 0.44 X 10(-5) ml O2.mmHg-1.ml-1) and VO2-axis intercept (0.040 +/- 0.009 ml O2.beat-1.100 g-1) were similar to values found in the dog left ventricle. Hence, despite the greatly different heart size, the base-line contractile state and chemomechanical energy conversion efficiency of the excised, cross-circulated rabbit left ventricle are similar to those of the dog left ventricle.
The First Generation of β‐Galactosidase‐Responsive Prodrugs Designed for the Selective Treatment of Solid Tumors in Prodrug Monotherapy (2012)

Massive attack: Galactoside prodrugs have been designed that can be selectively activated by lysosomal β-galactosidase located inside cancer cells expressing a specific tumor-associated receptor. This efficient enzymatic process triggers a potent cytotoxic effect, releasing the potent antimitotic agent MMAE and allowing the destruction of both receptor-positive and surrounding receptor-negative tumor cells.
Dependence of Calculus Retropulsion Dynamics on Fiber Size and Radiant Exposure During Ho:YAG Lithotripsy (2004)

During pulsed laser lithotripsy, the calculus is subject to a strong recoil momentum which moves the calculus away from laser delivery and prolongs the operation. This study was designed to quantify the recoil momentum during Ho:YAG laser lithotripsy. The correlation among crater shape, debris trajectory, laser-induced bubble and recoil momentum was investigated. Calculus phantoms made from plaster of Paris were ablated with free running Ho:YAG lasers. The dynamics of recoil action of a calculus phantom was monitored by a high-speed video camera and the laser ablation craters were examined with Optical Coherent Tomography (OCT). Higher radiant exposure resulted in larger ablation volume (mass) which increased the recoil momentum. Smaller fibers produced narrow craters with a steep contoured geometry and decreased recoil momentum compared to larger fibers. In the presence of water, recoil motion of the phantom deviated from that of phantom in air. Under certain conditions, we observed the phantom rocking towards the fiber after the laser pulse. The shape of the crater is one of the major contributing factors to the diminished recoil momentum of smaller fibers. The re-entrance flow of water induced by the bubble collapse is considered to be the cause of the rocking of the phantom.
The effects of naloxone on human breast cancer progression: in vitro and in vivo studies on MDA.MB231 cells (2018)

Our data showed, for the first time, that naloxone reduced breast cancer progression without affecting angiogenesis.
Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution (2006)

Transgenic mice have been increasingly utilized to investigate the molecular mechanisms of cardiac arrhythmias, yet the rate dependence of the murine action potential duration and the electrical restitution curve (ERC) remain undefined. In the present study, 21 isolated, Langendorff-perfused, and atrioventricular node-ablated mouse hearts were studied. Left ventricular and left atrial action potentials were recorded using a validated miniaturized monophasic action potential probe. Murine action potentials (AP) were measured at 30, 50, 70, and 90% repolarization (APD(30)-APD(90)) during steady-state pacing and varied coupling intervals to determine ERCs. Murine APD showed rate adaptation as well as restitution properties. The ERC time course differed dramatically between early and late repolarization: APD(30) shortened with increasing S1-S2 intervals, whereas APD(90) was prolonged. When fitted with a monoexponential function, APD(30) reached plateau values significantly faster than APD(90) (tau = 29 +/- 2 vs. 78 +/- 6 ms, P < 0.01, n = 12). The slope of early APD(90) restitution was significantly <1 (0.16 +/- 0.02). Atrial myocardium had shorter final repolarization and significantly faster ERCs that were shifted leftward compared with ventricular myocardium. Recovery kinetics of intracellular Ca(2+) transients recorded from isolated ventricular myocytes at 37 degrees C (tau = 93 +/- 4 ms, n = 18) resembled the APD(90) ERC kinetics. We conclude that mouse myocardium shows AP cycle length dependence and electrical restitution properties that are surprisingly similar to those of larger mammals and humans.
Simultaneous implementation of Gigabit Ethernet, RF TV and radio mm-wave in a multiformat Home Area Network (2011)

We demonstrate a high throughput multiformat Home Area Network supporting simultaneously on a unique optical infrastructure Gigabit Ethernet, terrestrial TV and 60GHz wireless connectivity. Hybrid electrical/optical multiplexing is used to maintain system low cost.
Two Enzymes for the Detoxicatlon of Organophosphorus Compounds—Sources, Similarities, and Significance (1984)

Two Enzymes for the Detoxication of Organophosphorus Compounds—Sources, Similarities, and Significance. HOSKIN, F. C. G., KIRKISH, M. A., AND STEINMANN, K. E. (1984). Fundam, Appl. Toxicol. 4, S165–S172. An enzyme in E. coli that hydrolyzes diisopropylphosphorofluoridate (DFP) has now been found to hydrolyze the nerve gas 1,2,2-trimethylpropylmethylphosphonofluoridate (soman) many times faster. With either substrate the E. coli enzyme is stimulated manyfold by 10−3 M Mn2+. These criteria are combined and applied to this, and to a superficially similar but distinctly different, enzyme found in squid nerve. The results suggest that while several tissues of the squid contain only this second kind of DFP hydrolyzing enzyme, termed squid type DFPase, many other sources including E. coli contain a mixture of squid type DFPase (the name not strictly indicative of source) and the other DFP hydrolyzing enzyme, now termed Mazur type DFPase. Procedures for the purification of Mazur type DFPase from hog kidney, while increasing the specific activity for DFP hydrolysis may actually have been enriching the purified material in the squid type DFPase. Because E. coli has the highest soman hydrolyzing capacity of any source so far examined, this organism is a promising source for the development of new purification procedures for Mazur type DFPase.
APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction (2016)

<i>APOL1</i> G1 and G2 variants facilitate kidney disease in blacks. To elucidate the pathways whereby these variants contribute to disease pathogenesis, we established HEK293 cell lines stably expressing doxycycline-inducible (Tet-on) reference <i>APOL1</i> G0 or the G1 and G2 renal-risk variants, and used Illumina human HT-12 v4 arrays and Affymetrix HTA 2.0 arrays to generate global gene expression data with doxycycline induction. Significantly altered pathways identified through bioinformatics analyses involved mitochondrial function; results from immunoblotting, immunofluorescence, and functional assays validated these findings. Overexpression of <i>APOL1</i> by doxycycline induction in HEK293 Tet-on G1 and G2 cells led to impaired mitochondrial function, with markedly reduced maximum respiration rate, reserve respiration capacity, and mitochondrial membrane potential. Impaired mitochondrial function occurred before intracellular potassium depletion or reduced cell viability occurred. Analysis of global gene expression profiles in nondiseased primary proximal tubule cells from black patients revealed that the nicotinate phosphoribosyltransferase gene, responsible for NAD biosynthesis, was among the top downregulated transcripts in cells with two <i>APOL1</i> renal-risk variants compared with those without renal-risk variants; nicotinate phosphoribosyltransferase also displayed gene expression patterns linked to mitochondrial dysfunction in HEK293 Tet-on <i>APOL1</i> cell pathway analyses. These results suggest a pivotal role for mitochondrial dysfunction in <i>APOL1</i>-associated kidney disease.
Electric-double-layer-gated transistors based on two-dimensional crystals: recent approaches and advances (2020)

Abstract Electric-double-layer (EDL) gated transistors use ions in an electrolyte to induce charge in the channel of the transistor by field-effect. Because a sub-nanometer gap capacitor is created at the electrolyte/channel interface, large capacitance densities (∼ µ F cm −2 ) corresponding to high sheet carrier densities (10 14 cm −2 ) can be induced, exceeding conventional gate dielectrics by about one order of magnitude. Because it is an interfacial technique, EDL gating is especially effective on two-dimensional (2D) crystals, which—at the monolayer limit—are basically interfaces themselves. Both solid polymer electrolytes and ionic liquids are routinely used as ion-conducting gate dielectrics, and they have provided access to regimes of transport in 2D materials that would be inaccessible otherwise. The technique, now widely used, has enabled the 2D crystal community to study superconductivity, spin- and valleytronics, investigate electrical and structural phase transitions, and create abrupt p-n junctions to generate tunneling, among others. In addition to using EDL gating as a tool to investigate properties of the 2D crystals, more recent efforts have emerged to engineer the electrolyte to add new functionality and device features, such as synaptic plasticity, bistability and non-volatility. Example of potential applications include neuromorphic computing and non-volatile memory. This review focuses on using ions for electrostatic control of 2D crystal transistors both to uncover basic properties of 2D crystals, and also to add new device functionalities.
Chromatic dispersion compensation in coherent transmission system using digital filters (2010)

We present a comparative analysis of three popular digital filters for chromatic dispersion compensation: a time-domain least mean square adaptive filter, a time-domain fiber dispersion finite impulse response filter, and a frequency-domain blind look-up filter. The filters are applied to equalize the chromatic dispersion in a 112-Gbit/s non-return-to-zero polarization division multiplexed quadrature phase shift keying transmission system. The characteristics of these filters are compared by evaluating their applicability for different fiber lengths, their usability for dispersion perturbations, and their computational complexity. In addition, the phase noise tolerance of these filters is also analyzed.