gebhart/patrepeval huggingface dataset:
Antiepileptic Potential of Cannabidiol Analogs (1981)

In audiogenic seizure (AGS) susceptible rats, the acute (intraperitoneal and intravenous) dose-response effects of (--)-cannabidiol (CBD) for preventing AGS and for causing rototod neurotoxicity (ROT) were determined. Also, the anti-AGS and ROT effects of 10 CBD analogs, given in intravenous doses equivalent to the AGS-ED50 (15 mg/kg) and ROT-ID50 (31 mg/kg) of CBD, were ascertained. Compared to CBD, (--)-CBD diacetate and (--)-4-(2'-olivetyl)-alpha-pinene were equally effective whereas (--)-CBD monomethyl ether, (--)-CBD dimethyl ether, (--)-3'-acetyl-CBD monoacetate, (+)-4-(2'-olivetyl)-alpha-pinene, (--)-and (+)-4-(6'-olivetyl)-alpha-pinene, (+/-)-AF-11, and olivetol were less effective anticonvulsants. Except for (--)- and (+)-4-(2'-olivetyl)-alpha-pinene and olivetol, all analogs showed less ROT than CBD. Also, CBD and all analogs were not active in tetrahydrocannabinol seizure-susceptible rabbits, the latter a putative model of cannabinoid psychoactivity in humans. These data suggest anticonvulsant requirements of 2 free phenolic hydroxyl groups, exact positioning of the terpinoid moiety in the resorcinol system and correct stereochemistry. Moreover, findings of separation of anticonvulsant from neurotoxic and psychoactive activities, notably with CBD diacetate, suggest that additional structural modifications of CBD may yield novel antiepileptic drugs.
A Unified Theory of Time-Frequency Reassignment (2009)

Time-frequency representations such as the spectrogram are commonly used to analyze signals having a time-varying distribution of spectral energy, but the spectrogram is constrained by an unfortunate tradeoff between resolution in time and frequency. A method of achieving high-resolution spectral representations has been independently introduced by several parties. The technique has been variously named reassignment and remapping, but while the implementations have differed in details, they are all based on the same theoretical and mathematical foundation. In this work, we present a brief history of work on the method we will call the method of time-frequency reassignment, and present a unified mathematical description of the technique and its derivation. We will focus on the development of time-frequency reassignment in the context of the spectrogram, and conclude with a discussion of some current applications of the reassigned spectrogram.
Lattice Boltzmann methods for modeling microscale flow in fibrous porous media (1997)

A lattice Boltzmann description of fluid flow in heterogeneous porous media is presented which is intended for modeling flow processes which occur in liquid composite molding applications. The lattice Boltzmann method is equivalent to solving a hybrid method of the Stokes and Brinkman equations, with the Brinkman equation being implemented to model flow through porous structures, while the Stokes equation is applied to the open regions outside the porous structures. The Brinkman equation is recovered through a modification of the particle equilibrium distribution function, which reduces the magnitude of momentum at specified lattice sites, while leaving the direction of momentum unchanged. As a test of the new lattice Boltzmann model, steady transverse flow (saturated) through a square array of porous cylinders of elliptical cross section is investigated. Cell permeabilities obtained from the lattice Boltzmann simulations are in excellent agreement with a lubrication model, validating the lattice Boltzmann formulation of the Stokes and Brinkman equations.
Rat liver and plasma lipids after carbon tetrachloride administration (1965)

Oral administration of CCl4 to rats produced (a) decreased cholesterol, phospholipid, and triglyceride plasma concentrations and elevated triglyceride levels in liver, (6) several hours later, a growing increase in plasma FFA, and (c) still later, increased plasma cholesterol, triglyceride, and phospholipid concentrations and continually rising liver triglyceride.The accumulation of hepatic triglyceride induced by CCl4 was smaller after administration of sympathetic anti-release agents; larger after administering a ganglion-blocking agent; smaller after the animals had been cord-sectioned; reduced by adrenalectomy and (to a much lesser extent) by bilateral splanchnicectomy. Corticoid treatment partially restored the response to CCl4 in adrenalectomized animals. Cord section prevented the plasma FFA increase induced by CCl4, although it did not modify the decrease in plasma phospholipid; both adrenalectomy and hypophysectomy also prevented the CCl4-induced plasma FFA increase.The results are interpreted as indicating that both adrenal corticoids and an intact sympathetic nervous system are necessary for fatty liver induction by CCl4.
Enteric Film Coating Using Completely Aqueous Dissolved Hydroxypropyl Methyl Cellulose Phthalate Spray Solutions (1982)

A completely aqueous film coating spray system has been developed for the enteric film coating of tablets. The method uses conventional aqueous film coating equipment and techniques. The coatings produced compare in enteric quality with the best that can be achieved with enteric film coatings applied from organic solutions. Dissolution rate data were mainly used to judge the enteric quality, and such data for a number of enteric film coating trials are presented.
A multi‐center, double‐blind, randomized controlled study of the safety and effectiveness of Juvéderm <sup>®</sup> injectable gel with and without lidocaine (2009)

The dermal filler formulated with lidocaine is effective in reducing procedural pain during correction of facial wrinkles and folds while maintaining a similar safety and effectiveness profile to the filler without lidocaine.
Language modelling for Turkish as an agglutinative language (2004)

Two types of language models have been considered for Turkish continuous speech recognition. In one case, words are separated into their stems and the rest, and language models are calculated based on this new set of units. In the other case, words are considered as a whole, but language models are calculated with respect to the stems of the words. Studies are carried out for bigram and trigram formalisms.
Oxyfunctionalization of Benzofurans by Singlet Oxygen, Dioxiranes, and Peracids: Chemical Model Studies for the DNA-Damaging Activity of Benzofuran Dioxetanes (Oxidation) and Epoxides (Alkylation) (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxyfunctionalization of Benzofurans by Singlet Oxygen, Dioxiranes, and Peracids: Chemical Model Studies for the DNA-Damaging Activity of Benzofuran Dioxetanes (Oxidation) and Epoxides (Alkylation)Markus Sauter and Waldemar AdamCite this: Acc. Chem. Res. 1995, 28, 7, 289–298Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://doi.org/10.1021/ar00055a002RIGHTS & PERMISSIONSArticle Views454Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (955 KB) Get e-Alerts Get e-Alerts
Forensic Engineering Evaluation Of Co2 Re-Breathing In Infant Bedding Materials (2012)

A Four-Month-Old Infant Suffocated In His Sleep From Positional Asphyxia. The Baby Was Found Face Down On A Foam Wedge Pillow Called A Sleep Positioner. The Author Was Engaged To Evaluate The Sleep Positioner Product For Its Potential To Cause Carbon Dioxide (Co2) Re-Breathing In Infants. Prior Research On This Subject Had Already Established A Reliable Method Of Simulating Infant Breathing And Measurement Of Respiratory Gas Constituents Using A Mechanical Breathing Model. Guided By This Research, A Mechanical Breathing Model And Gas Sampling Apparatus Was Coupled To A Mannequin Representing The Child In This Matter. The Mannequin Was Placed In Face-Down And Sidefacing Positions On The Sleep Positioner Product And Twelve Other Surfaces, Including A Plain Cotton Sheet As The Baseline. The Sleep Positioner Product Produced The Highest (And Most Dangerous) Level Of Co2 Re-Breathing, More Than Three Times The Baseline Level. Factors Contributing To Co2 Re-Breathing Are Discussed.
Fast Production of Technical Prototypes Using Direct Laser Sintering of Metals and Foundry Sand (2018)

Currently most RP-Parts are used for visualisation, assembly checks and some functional\ntesting. The next stage between these functional prototypes and the pre-series is technical\nprototypes, which are used for final functional testing and optimisation of the production\nprocess. These must not only have the same material as the series parts, but must also be\nmanufactured with the same production process. Due to the second ofthese requirements layer\nmanufacturing processes cannot be used to build these prototypes directly, but they can be used\nto make the negative moulds or tools.\nTwo new RP-processes based on laser sintering now have the capability to produce the moulds\nand tools via very short and fast process chains. Both have already been in commercial use in\nEurope for about one year.\nThe first process manufactures tools for injection moulding of plastic parts by Direct Metal\nLaser Sintering (DMLS). The second process, called the Direct Croning Process (DCP), is used\nto build sand moulds and cores for sand casting of metal parts directly from Croning-Sand\nwithout any tools. These technologies have been developed by EOS GmbH, Munich, and are\nmarketed under the names EOSINT M and EOSINT S respectively
Influence of whitening on the degree of conversion of dental adhesives on dentin (2006)

The aim of this study was to analyze the extent of polymerization of different adhesive systems on whitened dentin. One adhesive of each class was investigated: Adper Scotchbond Multi Purpose (3M ESPE); One-Step (Bisco); Clearfil Protect Bond (Kuraray); and Xeno III (Dentsply DeTrey). Dentin disks were treated with Opalescence Xtra Boost (Ultradent) for 30 min and bonded immediately after 24 h or after 14 d of storage in 100% humidity at 37 degrees C. Unbleached dentin disks were prepared as controls. The extent of polymerization of bonded interfaces was obtained with differential scanning calorimetry (DSC) at 20, 40 and 60 s, and the data were statistically analyzed. The extent of polymerization obtained from DSC exotherms of adhesives applied immediately after whitening was significantly lower compared with controls. An increased extent of polymerization after storage was confirmed for all adhesives, and no difference with controls was found after 14 d. A prolonged irradiation time increased the curing rate for all the tested adhesives. This study supports the hypothesis that polymerization of the adhesive is reduced after dentin whitening and that delayed adhesive application reverses the polymerization inhibition. Prolonged polymerization intervals may counteract the inhibition of polymerization caused by the whitening procedure. Nevertheless, further in vivo studies should validate this issue.
BNT162b2 vaccine booster dose protection: A nationwide study from Israel (2021)

Abstract Background On July 30, 2021, a third (booster) dose of the Pfizer BNT162b2 vaccine was approved in Israel for individuals 60 years or older who had been fully vaccinated (i.e., received two doses) at least five months previously. Here, we estimate the reduction in relative risk for confirmed infection and severe COVID-19 provided by the booster dose. Methods 1,144,690 individuals aged 60y and older who were eligible for a booster dose were followed between July 30 and August 22, 2021. We defined dynamic cohorts where individuals initially belong to the ‘non-booster’ cohort, leave it when receiving the booster dose and join the ‘booster’ cohort 12 days later. Rates of infection and severe COVID-19 outcomes per person-days at risk were compared between the cohorts using Poisson regression, adjusting for possible confounding factors. Results Twelve days or more after the booster dose we found an 11.4-fold (95% CI: [10.0, 12.9]) decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness. Under a conservative sensitivity analysis, we find ≈5-fold protection against confirmed infection. Conclusions In conjunction with safety reports, this study demonstrates the effectiveness of a third vaccine dose in both reducing transmission and severe disease and indicates the great potential of curtailing the Delta variant resurgence by administering booster shots.
SEARCH TERM RELEVANCE WEIGHTING GIVEN LITTLE RELEVANCE INFORMATION (1979)

Previous experiments demonstrated the value of relevance weighting for search terms, but relied on substantial relevance information for the terms. The present experiments were designed to study the effects of weights based on very limited relevance information, for example supplied by one or two relevant documents. The tests simulated iterative searching, as in an on‐line system, and show that even very little relevance information can be of considerable value.
Refinement of the crystal structure of zirconium tritellurate(IV), ZrTe3O8 (2003)

Abstract O 8 Te 3 Zr, cubic, Ia 3̅ (No. 206), a = 11.308(1) Å, V = 1446.0Å 3 , Z = 8, ρ m = 5.50(3) g·cm -3 , R gt (F) = 0.024, wR ref (F 2 ) = 0.049, T = 293 K.
A comparison of naloxone and naltrexone in laboratory tests predictive of antipsychotic potential (1983)

Abstract Naloxone and naltrexone were compared neuropharmacologically, especially in several rodent models considered to be predictive of antipsychotic activity, since narcotic antagonists have been reported to be effective in the treatment of schizophrenia. Naltrexone was found to be a potent antagonist of amphetamine‐induced aggregate toxicity in mice; this was in marked contrast to naloxone, which enhanced amphetamine's toxicity. Both naloxone and naltrexone exhibited an unusual profile of activity in the apomorphine‐induced stereotypy test in mice in that they antagonized the chewing behavior but failed to antagonize the rearing; this is in contrast to the activity of standard neurolepitcs (e.g., haloperidol, clozapine) which antagonize both behaviors induced by apomorphine. Neither of the narcotic antagonists exhibited any activity in several other tests predictive of antipsychotic activity. Naltrexone was a potent inhibitor of spontaneous locomotor activity in mice; naloxone, although much weaker, also antagonized motor activity. Thus, endorphins may play a role in the modulation of exploratory or locomotor activity. The marked difference in activity between the two antagonists in the amphetamine aggregate toxicity study may indicate a significant neuropharmacological difference between these agents; i.e., naltrexone may be much more than merely a more potent naloxone. Furthermore, naltrexone's potent activity as an antagonist of amphetamine‐induced aggregate toxicity in mice may be predictive of a better therapeutic effect in schizophrenia than has been observed with naloxone.
Association of the Leukocyte Plasma Membrane with the Actin Cytoskeleton through Coiled Coil-mediated Trimeric Coronin 1 Molecules (2005)

Coronin 1 is a member of the coronin protein family specifically expressed in leukocytes and accumulates at sites of rearrangements of the F-actin cytoskeleton. Here, we describe that coronin 1 molecules are coiled coil-mediated homotrimeric complexes, which associate with the plasma membrane and with the cytoskeleton via two distinct domains. Association with the cytoskeleton was mediated by trimerization of a stretch of positively charged residues within a linker region between the N-terminal, WD repeat-containing domain and the C-terminal coiled coil. In contrast, neither the coiled coil nor the positively charged residues within the linker domain were required for plasma membrane binding, suggesting that the N-terminal, WD repeat-containing domain mediates membrane interaction. The capacity of coronin 1 to link the leukocyte cytoskeleton to the plasma membrane may serve to integrate outside-inside signaling with modulation of the cytoskeleton.
Delignification of hardwoods by autohydrolysis and extraction. (1978)

Autohydrolysis of Eucalyptus saligna, Poplar tremuloides, and fast-growing poplar chips at 175 to 220/sup 0/ induced lignin (I) solubility in dioxane-H/sub 2/O mixture (9:1) or 1% NaOH. The I solubility exhibited a maximum characteristic of autohydrolysis temperature, and maximum delignification was achieved in a narrow time range at each temperature of autohydrolysis. Longer autohydrolysis reduced the I solubility, at the point of maximum I solubility, autohydrolysis aspen chip were readily defiberized, even without the subsequent extraction. E. saligna and fast-growing poplar also gave similar results.
Dihydroxylation of Vinyl Sulfones: Stereoselective Synthesis of (+)- and (−)-Febrifugine and Halofuginone (2009)

The asymmetric dihydroxylation of amino-functionalized vinyl sulfone 19 has been used for the 3-step preparation of 3-hydroxylpiperidine 24 in 86% enantiomeric excess. This enantiomerically enriched building block was used then to synthesize the naturally occurring antimalarial alkaloid febrifugine 1 and its antiangiogenic analogue, halofuginone 3.
Open Systems Advanced Workstation Transition Report (2000)

Abstract : U.S. Navy Command and Control systems require complex task support from shipboard workstations that receive information from various sources and display information multiple modalities of operators. The specific multimodalities involve touch and voice inputs with visual and 3-D auditory outputs. This report describes the development of the Open Systems Advanced Workstation (OSAW) and presents guidelines for using multi-modal technologies.
Is serum albumin an independent predictor of survival in patients with breast cancer? (2003)

Univariate statistical analysis found that low levels of serum albumin adversely affected survival by a statistically significant level for all stages of breast cancer. We found that a baseline serum albumin level was a powerful prognostic variable, which accounted for 7.35% of the variation in patient survival time.
Improved synchronization performance in DSSS systems using concatenated sequences (2003)

This paper deals with the synchronization properties of a family of spreading codes, called concatenated codes. New synchronization algorithms are introduced, and the performance of these algorithms is discussed both analytically and by simulation. It turns out that with a minimum of extra hardware, the mean phase acquisition time can be considerably reduced, while maintaining the reliability of the synchronization process at low power consumption.
Silage fermentation of fish or fish waste products with lactic acid bacteria (1983)

Abstract Silage fermentation of minced fish and fish offal after inoculation with cereals prefermented with Pediococcus acidilactici and Lactobacillus plantarum initiates a rapid fall in pH to below 4.5 within 30 h, and the content of competing gram‐negative fermenters and fish pathogens, such as Vibrio anguillarum and Aeromonas salmonicida , is eliminated. The addition of 0.1% sorbic acid inhibits the growth of yeasts during the initial fermentation period and during storage but does not affect the lactic acid fermentation. Degradation of nitrogen components proceeds during storage and is manifested as an increase in volatile basic nitrogen compounds, amino acids and peptides. These substances increase the pH and/or force the bacteria to produce more acid. The rate of production of these basic substances is mainly temperature‐dependent and cannot be attributed to microbial activity. The proteolytic activity is mainly caused by tissue proteases (e.g., cathepsins) and, to a lower degree, by gut proteases. It is doubtful whether fish fermentation can be utilised on an industrial scale without improving the technique. Such improvements consist of the selection and use of psychotrophic lactic acid fermenters and commercially acceptable inhibitors of proteolytic activity and yeast growth.
Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development (2012)

The purpose of this work was to investigate the potential of functionalized magnetite nanoparticles to improve the antibiofilm properties of textile dressing, tested in vitro against monospecific Candida albicans biofilms. Functionalized magnetite (Fe3O4/C18), with an average size not exceeding 20 nm, has been synthesized by precipitation of ferric and ferrous salts in aqueous solution of oleic acid (C18) and NaOH. Transmission electron microscopy, X-ray diffraction analysis, and differential thermal analysis coupled with thermo gravimetric analysis were used as characterization methods for the synthesized Fe3O4/C18. Scanning electron microscopy was used to study the architecture of the fungal biofilm developed on the functionalized textile dressing samples and culture-based methods for the quantitative assay of the biofilm-embedded yeast cells. The optimized textile dressing samples proved to be more resistant to C. albicans colonization, as compared to the uncoated ones; these functionalized surfaces-based approaches are very useful in the prevention of wound microbial contamination and subsequent biofilm development on viable tissues or implanted devices.
Anti-Citrulline Antibodies in the Diagnosis and Prognosis of Rheumatoid Arthritis: Evolving Concepts (2007)

Citrulline is a non-standard amino acid that can be incorporated into proteins only by post-translational modification of arginine by peptidylarginine deiminase (PAD) enzymes during a variety of biologic processes, including inflammation. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, with a prevalence of 0.3 to 1% worldwide, which leads to progressive joint erosion and substantial disability if not treated early. A reliable and specific test for a marker present early in the disease would be useful to identify RA patients prior to the occurrence of joint damage. A new group of autoantibodies, the anti-cyclic citrullinated peptide antibodies (anti-CCP), can be detected in up to 80% of patients with RA, are highly specific for the disease, and may be of value for both the diagnosis and the prognosis of RA. The fact that these antibodies may appear before the onset of the disease suggests a potential role in primary prevention. Interestingly, they may also play a role in the pathophysiology of this disabling disease. The process of citrullination, its physiologic role, and citrullination-related pathologies, as well as the use of anti-citrullinated protein antibody tests (ACPA) for the early diagnosis and prognosis of RA and their potential role in the pathophysiology of the disease, are discussed.