gebhart/patrepeval huggingface dataset:
Simultaneous analysis of relative DNA and glutathione content in viable cells by phase-resolved flow cytometry (1999)

Phase-resolved flow cytometry provides a means for the specific analysis of the GSH content/concentration as a function of the cell's position in the DNA cell cycle in viable cells.
Bulk Stabilization in Wax Deposition Systems (2004)

Managing paraffin deposition in crude oil transport pipelines comprises a significant operating expense for petroleum producers. Incipient wax−oil gel deposits age with time via a counter-diffusion mechanism where there exists a critical carbon number (CCN); wax molecules with carbon numbers greater than the CCN diffuse from the bulk fluid into the gel, and vice versa. Paraffin deposit samples were obtained from a real crude oil using a coldfinger wax deposition device and were analyzed by gas chromatography. Comparison of bulk oil and deposit compositions demonstrates that crystallization of n-paraffin components occurs at lower carbon numbers than analogous non-n-paraffin hydrocarbon components. A new concept is introduced of using the depletion of paraffin components from the bulk solution to delineate aging and incipient gelation phenomena. Depletion is defined as the normalized decrease in mass fraction of a paraffin component in the bulk fluid during deposition. Deposition performed using model fluids demonstrates that depletion is dependent upon the bulk fluid temperature. When the bulk fluid temperature is maintained lower than the cloud point, the highest molecular weight components form stable crystals in the bulk fluid, effectively sequestering the components from the liquid phase and reducing molecular diffusion into the gel deposit. At sufficiently low bulk fluid temperature conditions, an “upper CCN” value establishes an upper bound to the molecular weight range of paraffin components which contribute to the aging process. An analysis of a field deposit confirms the aging behavior of paraffin deposits observed on the coldfinger, and indicates that CCN values are in the mid 20's at field conditions.
Levuglandinyl Adducts of Proteins Are Formed via a Prostaglandin H2 Synthase-dependent Pathway after Platelet Activation (2003)

The product of oxygenation of arachidonic acid by the prostaglandin H synthases (PGHS), prostaglandin H(2) (PGH(2)), undergoes rearrangement to the highly reactive gamma-ketoaldehydes, levuglandin (LG) E(2), and LGD(2). We have demonstrated previously that LGE(2) reacts with the epsilon-amine of lysine to form both the levuglandinyl-lysine Schiff base and the pyrrole-derived levuglandinyl-lysine lactam adducts. We also have reported that these levuglandinyl-lysine adducts are formed on purified PGHSs following the oxygenation of arachidonic acid. We now present evidence that the levuglandinyl-lysine lactam adduct is formed in human platelets upon activation with exogenous arachidonic acid or thrombin. After proteolytic digestion of the platelet proteins, and isolation of the adducted amino acid residues, this adduct was identified by liquid chromatography-tandem mass spectrometry. We also demonstrate that formation of these adducts is inhibited by indomethacin, a PGHS inhibitor, and is enhanced by an inhibitor of thromboxane synthase. These data establish that levuglandinyl-lysine adducts are formed via a PGHS-dependent pathway in whole cells, even in the presence of an enzyme that metabolizes PGH(2). They also demonstrate that a physiological stimulus is sufficient to lead to the lipid modification of proteins through the levuglandin pathway in human platelets.
Biofilm-Like <i>Lactobacillus rhamnosus</i> Probiotics Encapsulated in Alginate and Carrageenan Microcapsules Exhibiting Enhanced Thermotolerance and Freeze-Drying Resistance (2013)

Microcapsules containing high-density biofilm-like Lactobacillus rhamnosus probiotics, in place of planktonic cells, are developed in order to enhance the cell viability upon exposures to stresses commonly encountered during food lifecycle (i.e., heating, freeze-drying, refrigerated storage, and acid). The high-density (HD) capsules are prepared by in situ cultivation of the planktonic cells in the confined space of polysaccharide-based capsules (i.e., chitosan-coated alginate and carrageenan capsules). Compared to their planktonic counterparts, the HD capsules exhibit higher freeze-drying resistance (~40×) and higher thermotolerance upon prolonged wet heat exposures at 60 and 70 °C (~12-8000×), but not at higher temperatures even for short exposures (i.e., 80 and 100 °C). The enhanced viability of the HD capsules, however, is not observed during the refrigerated storage and exposure to the simulated gastric juice. The alginate capsules are superior to carrageenan owed to their better cell release profile in the simulated intestinal juice and storage viability.
Numerical implementation of the multiple image optical compression and encryption technique (2015)

In this study, we propose a numerical implementation (using a GPU) of an optimized multiple image compression and encryption technique. We first introduce the double optimization procedure for spectrally multiplexing multiple images. This technique is adapted, for a numerical implementation, from a recently proposed optical setup implementing the Fourier transform (FT)<sup>1</sup>. The new analysis technique is a combination of a spectral fusion based on the properties of FT, a specific spectral filtering, and a quantization of the remaining encoded frequencies using an optimal number of bits. The spectral plane (containing the information to send and/or to store) is decomposed in several independent areas which are assigned according a specific way. In addition, each spectrum is shifted in order to minimize their overlap. The dual purpose of these operations is to optimize the spectral plane allowing us to keep the low- and high-frequency information (compression) and to introduce an additional noise for reconstructing the images (encryption). Our results show that not only can the control of the spectral plane enhance the number of spectra to be merged, but also that a compromise between the compression rate and the quality of the reconstructed images can be tuned. Spectrally multiplexing multiple images defines a first level of encryption. A second level of encryption based on a real key image is used to reinforce encryption. Additionally, we are concerned with optimizing the compression rate by adapting the size of the spectral block to each target image and decreasing the number of bits required to encode each block. This size adaptation is realized by means of the root-mean-square (RMS) time-frequency criterion<sup>2</sup>. We have found that this size adaptation provides a good trade-off between bandwidth of spectral plane and number of reconstructed output images<sup>3</sup>. Secondly, the encryption rate is improved by using a real biometric key and randomly changing the rotation angle of each block before spectral fusion. A numerical implementation of this method using two numerical devices (CPU and GPU) is presented<sup>4</sup>.
Fluorescent Functional Recognition Sites through Molecular Imprinting. A Polymer-Based Fluorescent Chemosensor for Aqueous cAMP (1998)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionFluorescent Functional Recognition Sites through Molecular Imprinting. A Polymer-Based Fluorescent Chemosensor for Aqueous cAMPPetra Turkewitsch, Barbara Wandelt, Graham D. Darling, and William S. PowellCite this: Anal. Chem. 1998, 70, 13, 2771Publication Date (Web):May 21, 1998Publication History Published online21 May 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/ac981558ghttps://doi.org/10.1021/ac981558gcorrectionACS PublicationsCopyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views694Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (10 KB) Get e-Alertsclose Get e-Alerts
Electro-optic imaging of internal fields in (111) GaAs photoconductors (1995)

The nonuniform electric field in a surface (111) GaAs photoconductor was imaged for the first time using the electro-optic effect of the device itself. The technique used a mode-locked 1.06 /spl mu/m laser with 150 ps pulses to transiently probe the electric field profile at various times following application of a synchronized pulsed voltage bias.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nucleotide modification at the  -phosphate leads to the improved fidelity of HIV-1 reverse transcriptase (2005)

The mechanism by which HIV-1 reverse transcriptase (HIV-RT) discriminates between the correct and incorrect nucleotide is not clearly understood. Chemically modified nucleotides containing 1-aminonaphthalene-5-sulfonate (ANS) attached to their g-phosphate were synthesized and used to probe nucleotide selection by this error prone polymerase. Primer extension reactions provide direct evidence that the polymerase is able to incorporate the gamma-modified nucleotides. Forward mutation assays reveal a 6-fold reduction in the mutational frequency with the modified nucleotides, and specific base substitutions are dramatically reduced or eliminated. Molecular modeling illustrates potential interactions between critical residues within the polymerase active site and the modified nucleotides. Our data demonstrate that the fidelity of reverse transcriptase is improved using modified nucleotides, and we suggest that specific modifications to the g-phosphate may be useful in designing new antiviral therapeutics or, more generally, as a tool for defining the structural role that the polymerase active site has on nucleotide selectivity.
Inelastic tunneling excitation of tip-induced plasmon modes on noble-metal surfaces (1991)

Light emission characteristics from the tunnel gap of a scanning tunneling microscope are used to elucidate the interaction of tunneling electrons with tip-induced plasmon modes on Ag, Au, and Cu surfaces. Enhanced redshifted spectra are observed in the tunneling regime. Model calculations of optical spectra in this range agree well with the experimental data. Isochromat spectra are used to demonstrate that the principal excitation process occurs via inelastic tunneling.
Financial Pollution: Systemic Risk and Market Stability (2008)

This Comment roughly documents events that occurred through the summer of 2008; while the crisis has evolved considerably since then, my analysis of
Launch Dynamics of APFSDS (Armor Piercing, Fin-Stabilized, Discarding Sabot) Ammunition (1984)

An experimental program to determine the magnitude and nature of the launch perturbations to the projectile angular motion during sabot discard is discussed. The data analysis isolates the sources and quantifies the severity of the launch perturbations. An explanation of how the discard dynamics may be related to the inbore motion of the round is presented. The results show that the discard disturbances cause a net increase of 41% in the level of first maximum yaw. For the different configurations tested changes in the inbore contribution to first maximum yaw indicate that the structural design of the front boreriding system is critical to the inbore behavior. A correlation is given between the angular rate to angle ratio at the muzzle and the severity of the discard interactions. Based on the correlation an alternate launch philosophy is necessary for APFSDS ammunition to assure on target accuracy. (Author)
Retinoids: Concepts for Separation of Desirable and Undesirable Effects in the Treatment or Prevention of Cancer (1996)

Since its discovery early this century, vitamin A has been known to play essential biological roles (Lotan, 1981; Roberts and Sporn, 1984; Morris-Kay 1992). It has now been established that the active derivatives of vitamin A such as all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA) as well as their synthetic analogs—the retinoids—function as hormone-like signaling molecules that affect important biological processes at the level of gene transcription. The ability of retinoids to regulate growth and development, cell proliferation, and differentiation made them particularly attractive as therapeutic candidates for the treatment of cancer and other proliferative diseases. In fact, 13-cis RA and related retinoids are the most effective drugs known today for the treatment of acne vulgaris and other skin diseases (reviewed in Schaefer and Reichert, 1990). In addition, ATRA has recently been approved for the treatment of acute promyelocytic leukemia (APL) where it leads to complete remission (Huang et al., 1988; Castaigne et al., 1990; Chen et al., 1991). Retinoids have also shown promise for the treatment and prevention of many other cancers including cancers of the head and neck, cervical cancer, and most other epithelial tissue-derived cancers (reviewed in Bollag and Holdener, 1992; Smith et al., 1992; Meyskens et al., 1994).
Speech-Centric Information Processing: An Optimization-Oriented Approach (2013)

Automatic speech recognition (ASR) is a central and common component of voice-driven information processing systems in human language technology, including spoken language translation (SLT), spoken language understanding (SLU), voice search, spoken document retrieval, and so on. Interfacing ASR with its downstream text-based processing tasks of translation, understanding, and information retrieval (IR) creates both challenges and opportunities in optimal design of the combined, speech-enabled systems. We present an optimization-oriented statistical framework for the overall system design where the interactions between the subsystems in tandem are fully incorporated and where design consistency is established between the optimization objectives and the end-to-end system performance metrics. Techniques for optimizing such objectives in both the decoding and learning phases of the speech-centric information processing (SCIP) system design are described, in which the uncertainty in speech recognition subsystem's outputs is fully considered and marginalized. This paper provides an overview of the past and current work in this area. Future challenges and new opportunities are also discussed and analyzed.
3‐Methoxynaltrexone, a selective heroin/morphine‐6β‐glucuronide antagonist (1997)

Recent work has suggested that heroin and morphine-6beta-glucuronide (M6G) both act through a novel mu opioid receptor subtype distinct from those mediating morphine's actions. This very high affinity 3H-M6G site is selectively competed by 3-methoxynaltrexone. In vivo, 3-methoxynaltrexone (2.5 ng, i.c.v.) selectively antagonizes the analgesic actions of heroin and M6G without interfering with mu (morphine and [D-Ala2,MePhe4,Gly(ol)5]enkephalin), delta ([D-Pen2,D-Pen5]enkephalin), kappa1 (U50,488H) or kappa3 (naloxone benzoylhydrazone) analgesia. In dose-response studies, 3-methoxynaltrexone (2.5 ng, i.c.v.) significantly shifted the ED50 values for heroin and its active metabolite, 6-acetylmorphine, without affecting the morphine curve. These results indicate that 3-methoxynaltrexone selectively blocks a novel 3H-M6G binding site which is responsible for the analgesic actions of heroin and M6G. This ability to selectively antagonize heroin actions opens new possibilities in the development of therapeutics for the treatment of opioid abuse.
Regioselective and Stereospecific Cross‐Coupling of Primary Allylic Amines with Boronic Acids and Boronates through Palladium‐Catalyzed CN Bond Cleavage (2012)

Die NH2-Gruppe fungiert in der palladiumkatalysierten regioselektiven und stereospezifischen Titelreaktion als effektive Abgangsgruppe (siehe Schema). Die Reaktion gelingt mit Aryl- und Alkenylboronsäuren sowie Aryl-, Alkenyl-, Allyl- und Benzylboronaten. Mit α-chiralen primären Allylaminen als allylischen Elektrophilen wurde ein vollständiger Chiralitätstransfer erreicht. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Vertical seismic profiling using distributed acoustic sensing in a hydrofrac treatment well (2014)

Distributed Acoustic Sensing (DAS) is a Fiber Optic (FO) cable based technology which is gaining importance for VSP surveys, especially for time-lapse monitoring of reservoirs. DAS offers distinct advantages over geophones but it also poses unique challenges, including receiver depth uncertainty and low signal-to-noise ratio. Here, we present an analysis of a DAS VSP acquired for monitoring purposes in a treatment well while a multi-stage hydraulic fracture treatment was ongoing in the same well. We describe the pre-processing needed before further time-lapse analysis of the VSP. We focus on two key steps - depth calibration and noise removal. Large spike noise, most likely from the DAS acquisition system, appears to be a major source of noise in the raw DAS data, but can be removed with careful processing. Other sources of noise include temperature fluctuations in the well and optical noise. We show that excellent quality VSP data can be obtained in a hydrofrac treatment well.
MashMaker (2007)

Article Share on MashMaker: mashups for the masses Authors: Robert J. Ennals Intel Research Berkeley, Berkeley, CA Intel Research Berkeley, Berkeley, CAView Profile , Minos N. Garofalakis Yahoo! Research, Santa Clara, CA Yahoo! Research, Santa Clara, CAView Profile Authors Info & Claims SIGMOD '07: Proceedings of the 2007 ACM SIGMOD international conference on Management of dataJune 2007 Pages 1116–1118https://doi.org/10.1145/1247480.1247626Online:11 June 2007Publication History 109citation39DownloadsMetricsTotal Citations109Total Downloads39Last 12 Months11Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Progress in Metathesis Through Natural Product Synthesis (2011)

Abstract This article covers case studies in natural product syntheses with comments on various aspects of metathesis reactions and on how the difficulties encountered in these syntheses have led to better understanding of these reactions or to more effective reaction conditions and catalysts. Ring‐closingmetathesis leading to small and medium‐sized rings is discussed, followed by macrocycle formation, asymmetric ring‐closing metathesis, and cross metathesis.
Examination of the temperature influence on the acousto-optic filters performance (2017)

Acousto-optic (AO) interaction is widely used in devices for analysis and control of optical radiation. Acousto-optic devices are mainly used for crystalline media possessing strong anisotropy. The properties of such materials may exhibit significant changes under the influence of temperature conditions affecting the device characteristics. This study considers the influence of temperature on the performance of wide-aperture AO filters based on KDP and TeO2 crystals.
Efficiently Processing Continuous k-NN Queries on Data Streams (2007)

Efficiently processing continuous k-nearest neighbor queries on data streams is important in many application domains, e. g. for network intrusion detection. Usually not all valid data objects from the stream can be kept in main memory. Therefore, most existing solutions are approximative. In this paper, we propose an efficient method for exact k-NN monitoring. Our method is based on three ideas, (1) selecting exactly those objects from the stream which are able to become the nearest neighbor of one or more continuous queries and storing them in a skyline data structure, (2) delaying to process those objects which are not immediately nearest neighbors of any query, and (3) indexing the queries rather than the streaming objects. In an extensive experimental evaluation we demonstrate that our method is applicable on high throughput data streams requiring only very limited storage.
Real‐time haptic manipulation and cutting of hybrid soft tissue models by extended position‐based dynamics (2015)

Abstract This paper systematically describes an interactive dissection approach for hybrid soft tissue models governed by extended position‐based dynamics. Our framework makes use of a hybrid geometric model comprising both surface and volumetric meshes. The fine surface triangular mesh with high‐precision geometric structure and texture at the detailed level is employed to represent the exterior structure of soft tissue models. Meanwhile, the interior structure of soft tissues is constructed by coarser tetrahedral mesh, which is also employed as physical model participating in dynamic simulation. The less details of interior structure can effectively reduce the computational cost during simulation. For physical deformation, we design and implement an extended position‐based dynamics approach that supports topology modification and material heterogeneities of soft tissue. Besides stretching and volume conservation constraints, it enforces the energy preserving constraints, which take the different spring stiffness of material into account and improve the visual performance of soft tissue deformation. Furthermore, we develop mechanical modeling of dissection behavior and analyze the system stability. The experimental results have shown that our approach affords real‐time and robust cutting without sacrificing realistic visual performance. Our novel dissection technique has already been integrated into a virtual reality‐based laparoscopic surgery simulator. Copyright © 2015 John Wiley & Sons, Ltd.
CDMA receiver performance for multiple-input multiple-output antenna systems (2002)

We consider the performance of a forward link (base-to-mobile) shared channel with and without a multiple-input multiple-output (MIMO) antenna system. A CDMA shared channel is analyzed and simulated for which users are served in a time division multiplexed (TDM) manner. The slot structure and chip rate are based on the wideband CDMA standard. Link-level simulations are presented to compare the performances of two different receivers: linear minimum mean-square-error (MMSE), and nonlinear (turbo/iterative) MMSE. In addition, MIMO performance is compared with and without antenna array weight feedback.