gebhart/patrepeval huggingface dataset:
Cylindrical geometry electroquasistatic dielectrometry sensors (2005)

Semianalytical models are used to simulate the response of periodic-field electroquasistatic dielectrometry sensors. Due to the periodic structure of the sensors it is possible to use Fourier transform methods in combination with collocation point numerical techniques to generate accurate sensor simulations much more efficiently than with the more general finite-element methods. The models previously developed for Cartesian geometry sensors have been extended to sensors with cylindrical geometry. This enables the design of families of circularly symmetric dielectrometers with the "model-based" methodology, which requires close agreement between actual sensor response and simulated response. These kinds of sensors are needed in applications where the components being tested have circular symmetry, or if it is important to be insensitive to sensor orientation, in cases where a property shows some anisotropy. It is possible to extend the Fourier Series Cartesian geometry models to this case with the use of Fourier-Bessel Series over a radius large compared to the sensor dimensions. The validity of the cylindrical geometry model is confirmed experimentally, where the combined response of two circularly symmetric dielectric sensors with different depths of sensitivity is used to simultaneously measure the permittivity of a dielectric plate and its lift-off from the electrode surface
Smad7 as a therapeutic agent for chronic kidney diseases (2008)

Increasing evidence shows that transforming growth factor-beta TGF-beta1 (TGF-beta1) is upregulated and plays a diverse role in renal fibrosis by stimulating extracellular matrix (ECM) production, while inhibiting renal inflammation. Recent studies have identified that TGF-beta1, once activated, signals through its downstream signaling pathway to exert its biological effects. It is now well accepted that TGF-beta regulates fibrosis positively by receptor-associated Smads including Smad2 and Smad3, but negatively by an inhibitory Smad, called Smad7. We and other investigators have shown that gene transfer of Smad7 is able to inhibit renal fibrosis in a number of experimental models of chronic kidney diseases, including obstructive nephropathy, remnant kidney disease, and autoimmune crescentic glomerulonephritis. Blockade of Smad2/3 activation is a major mechanism by which overexpression of Smad7 inhibits renal scarring. Furthermore, our recent findings also demonstrate that Smad7 plays a critical role in anti-inflammation in chronic kidney diseases by blocking the NF.kappaB-dependent inflammatory pathway. Thus, Smad7 has a unique role in both anti-renal fibrosis and inflammation. These findings also indicate that targeting the TGF-beta/Smad signaling pathway by overexpressing Smad7 may provide a novel, specific, and effective therapy for chronic kidney diseases.
From Facepalm to Brain Bender (2015)

Although studies have shown that at least one in ten Web pages contains a client-side XSS vulnerability, the prevalent causes for this class of Cross-Site Scripting have not been studied in depth. Therefore, in this paper, we present a large-scale study to gain insight into these causes. To this end, we analyze a set of 1,273 real-world vulnerabilities contained on the Alexa Top 10k domains using a specifically designed architecture, consisting of an infrastructure which allows us to persist and replay vulnerabilities to ensure a sound analysis. In combination with a taint-aware browsing engine, we can therefore collect important execution trace information for all flaws. Based on the observable characteristics of the vulnerable JavaScript, we derive a set of metrics to measure the complexity of each flaw. We subsequently classify all vulnerabilities in our data set accordingly to enable a more systematic analysis. In doing so, we find that although a large portion of all vulnerabilities have a low complexity rating, several incur a significant level of complexity and are repeatedly caused by vulnerable third-party scripts. In addition, we gain insights into other factors related to the existence of client-side XSS flaws, such as missing knowledge of browser-provided APIs, and find that the root causes for Client-Side Cross-Site Scripting range from unaware developers to incompatible first- and third-party code.
Response time characteristics of the pCO2 electrode (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResponse time characteristics of the pCO2 electrodeM. A. Jensen and G. A. RechnitzCite this: Anal. Chem. 1979, 51, 12, 1972–1977Publication Date (Print):October 1, 1979Publication History Published online1 May 2002Published inissue 1 October 1979https://pubs.acs.org/doi/10.1021/ac50048a019https://doi.org/10.1021/ac50048a019research-articleACS PublicationsRequest reuse permissionsArticle Views239Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure-taste relationship of perillartine and nitro- and cyanoaniline derivatives (1980)

The relationship between structure and taste potency of perillartine and its analogues was investigated quantitatively by physicochemical parameters and regression analysis. The results indicated that the hydrophobicity estimated from the 1-octanol/water partition coefficient and the molecular widths from the bond axis connecting the oxime carbon and alicyclic ring are important, regardless of whether the taste is sweet or bitter, so far as the taste potency is concerned. The SAR for the sweet/bitter ratio was not established quantitatively, but the molecular width and thickness and the position-specific electronic effect seem to delineate the ratio qualitatively; i.e., in principle, the wider and/or the thicker the molecule, the more bitter the taste. Comparatively, the QSAR of 5-nitro- and 5-cyanoaniline sweetners was formulated to show the insignificance of the hydrophobicity within the compounds investigated but the importance of the steric dimensions in determining the activity.
M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1 (2017)

Despite its prominent role as a C-type lectin (CTL) pattern recognition receptor, mannose receptor (MR, CD206)-specific signaling molecules and pathways are unknown. The MR is highly expressed on human macrophages, regulating endocytosis, phagocytosis, and immune responses and mediating Mycobacterium tuberculosis (M.tb) phagocytosis by human macrophages, thereby limiting phagosome-lysosome (P-L) fusion. We identified human MR-associated proteins using phosphorylated and non-phosphorylated MR cytoplasmic tail peptides. We found that MR binds FcRγ-chain, which is required for MR plasma membrane localization and M.tb cell association. Additionally, we discovered that MR-mediated M.tb association triggers immediate MR tyrosine residue phosphorylation and Grb2 recruitment, activating the Rac/Pak/Cdc-42 signaling cascade important for M.tb uptake. MR activation subsequently recruits SHP-1 to the M.tb-containing phagosome, where its activity limits PI(3)P generation at the phagosome and M.tb P-L fusion and promotes M.tb growth. In sum, we identify human MR signaling pathways that temporally regulate phagocytosis and P-L fusion during M.tb infection.
AsterixDB: A Scalable, Open Source BDMS (2014)

AsterixDB is a new, full-function BDMS (Big Data Management System) with a feature set that distinguishes it from other platforms in today's open source Big Data ecosystem. Its features make it well-suited to applications like web data warehousing, social data storage and analysis, and other use cases related to Big Data. AsterixDB has a flexible NoSQL style data model; a query language that supports a wide range of queries; a scalable runtime; partitioned, LSM-based data storage and indexing (including B+-tree, R-tree, and text indexes); support for external as well as natively stored data; a rich set of built-in types; support for fuzzy, spatial, and temporal types and queries; a built-in notion of data feeds for ingestion of data; and transaction support akin to that of a NoSQL store. Development of AsterixDB began in 2009 and led to a mid-2013 initial open source release. This paper is the first complete description of the resulting open source AsterixDB system. Covered herein are the system's data model, its query language, and its software architecture. Also included are a summary of the current status of the project and a first glimpse into how AsterixDB performs when compared to alternative technologies, including a parallel relational DBMS, a popular NoSQL store, and a popular Hadoop-based SQL data analytics platform, for things that both technologies can do. Also included is a brief description of some initial trials that the system has undergone and the lessons learned (and plans laid) based on those early "customer" engagements.
Restoration of function after brain damage using a neural prosthesis (2013)

Neural interface systems are becoming increasingly more feasible for brain repair strategies. This paper tests the hypothesis that recovery after brain injury can be facilitated by a neural prosthesis serving as a communication link between distant locations in the cerebral cortex. The primary motor area in the cerebral cortex was injured in a rat model of focal brain injury, disrupting communication between motor and somatosensory areas and resulting in impaired reaching and grasping abilities. After implantation of microelectrodes in cerebral cortex, a neural prosthesis discriminated action potentials (spikes) in premotor cortex that triggered electrical stimulation in somatosensory cortex continuously over subsequent weeks. Within 1 wk, while receiving spike-triggered stimulation, rats showed substantially improved reaching and grasping functions that were indistinguishable from prelesion levels by 2 wk. Post hoc analysis of the spikes evoked by the stimulation provides compelling evidence that the neural prosthesis enhanced functional connectivity between the two target areas. This proof-of-concept study demonstrates that neural interface systems can be used effectively to bridge damaged neural pathways functionally and promote recovery after brain injury.
Prevention of endotoxin shock by an antibody against leukocyte integrin β<sub>2</sub>through inhibiting production and action of TNF (1995)

Septic shock remains a serious disorder associated with high mortality. Accumulating evidence indicates that TNF is a major and essential mediator of endotoxin shock. We report here that administration of an antibody against CD18 dramatically reduced endotoxin-induced shock in rabbits as revealed by prevention of severe hypotension, metabolic acidosis and a pathological change suggestive of disseminated intravascular coagulation with concomitant inhibition of elevation of plasma TNF activity. The anti-CD18 antibody also inhibited the hypotension induced by administering recombinant TNF. Furthermore, an antibody against a ligand for CD18 complexes, intercellular adhesion molecule-1, also prevented TNF-induced shock as well as endotoxin shock in rabbits. These observations suggest that adhesion of leukocytes to endothelium may be of primary importance in the action of TNF as well as in the production of TNF in vivo and that the antibody against adhesion molecules could be of therapeutic benefit in life-threatening septic shock in humans.
Effects of dietary salt on angiotensin peptides in kidney. (1995)

This study used a novel simple method for the extraction, separation, identification, and quantitation of angiotensin-like immunoactivity from tissue to examine the effects of altering dietary NaCl intake on intrarenal angiotensin I, II, and III levels in salt-sensitive, spontaneously hypertensive rats, salt-resistant Wistar-Kyoto rats, and Sprague-Dawley rats. Seven-week-old male spontaneously hypertensive rats, Wistar-Kyoto rats, and Sprague-Dawley rats were assigned randomly to a diet containing either 8% (high) or 1% (basal) salt and were maintained on these diets for 3 wk. Rats were then decapitated without prior anesthesia, and kidneys were rapidly (< 30 s) removed, snap frozen in liquid nitrogen, and stored at -80 degrees C. Frozen tissue was extracted in 2 M acetic acid and then subjected to solid-phase extraction with the cation exchange resin AG 50W X4. Angiotensin peptides were separated by reversed-phase high-performance liquid chromatography on a phenyl silica gel column with an eluent consisting of 20% acetonitrile in 0.1 M ammonium phosphate buffer, pH 4.9, and quantitated by radioimmunoassay. The elution of standard peptides under isocratic conditions revealed clear resolution of angiotensin I, II, and III and the (1-7) and (3-8) peptides. Recoveries of both labeled and unlabeled angiotensin peptide standards from the extraction step were > 90%. Renal angiotensin II stores were significantly higher in spontaneously hypertensive rats than in Wistar-Kyoto or Sprague-Dawley rats, independent of diet. Renal angiotensin II and III were further suppressed during dietary salt supplementation in both salt-resistant strains but not in the spontaneously hypertensive rat. These findings are consistent with an enhanced (compared with Wistar-Kyoto and Sprague-Dawley rats) role for angiotensin II in the kidney of the salt-sensitive, spontaneously hypertensive rat, particularly under conditions of dietary salt supplementation.
Isolation of <i>Acinetobacter</i> from Soil and Water (1968)

An enrichment culture procedure for isolating members of the genus Acinetobacter from soil and water is described. It involves the use of vigorously aerated mineral media at relative low pH, supplemented with acetate or other suitable carbon source and nitrate as nitrogen source. With this method, virtually all samples of soil and water yielded representatives of this genus. Semiquantitative comparisons of the numbers of Acinetobacter and of all bacteria capable of aerobic growth in a complex medium revealed that Acinetobacter constituted no less than 0.001% of the total heterotrophic aerobic population in soil and water and was one of the predominant organisms in some water samples.
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast (2009)

The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals.
Resolution and signal-to-noise relationships in NMR imaging in the human body (1980)

When nuclear magnetic resonance techniques are applied to the imaging of structures deep inside the human body, it becomes important to consider the degrading effects of the surrounding body tissues on the signal-to-noise ratio of the received resonance signal. The passage of the NMR signal through the surrounding conductive tissue casues an appreciable loss of signal strength at high frequencies. Also, the presence of a large resistive medium, such as a portion of the body, inside the receiving coil causes a significant amount of thermal noise to be detected. The levels of the signal-to-noise ratio and the corresponding spatial resolution are quantitatively discussed in this paper. Expressions are obtained which enable the resolution to be estimated for a variety of medical imaging systems.
Biosensing with one-dimensional photonic bandgap structure (2004)

The optical properties of photonic bandgap (PBG) structures are highly sensitive to the geometry and refractive index. This makes PBG structures a good host for sensor applications. The binding of target species inside the PBG structure changes the refractive index of the material, which can be detected by monitoring the optical response of the device. One-dimensional PBG biosensors based on porous silicon (PSi) have been fabricated. The device is a microcavity, made of a symmetry breaking PSi layer (defect layer) inserted between two PSi Bragg mirrors. Narrow resonances are introduced in the photoluminescence and reflectance spectra. The large internal surface of the sensor is functionalized for the capture of target biological materials. When the sensor is exposed to the target, binding to the internal surface increases the effective optical thickness of the microcavity and thus causes a red shift of the optical spectrum. The sensor's sensitivity is determined by the morphology and geometry of the device. We will present the details of the materials science, sensor fabrication and optimization, and also describe experiments performed with biological targets.
Complex networks in brain electrical activity (2007)

This letter reports a method to extract a functional network of the human brain from electroencephalogram measurements. A network analysis was performed on the resultant network and the statistics of the cluster coefficient, node degree, path length, and physical distance of the links, were studied. Even given the low electrode count of the experimental data the method was able to extract networks with network parameters that clearly depend on the type of stimulus presented to the subject. This type of analysis opens a door to studying the cerebral networks underlying brain electrical activity, and links the fields of complex networks and cognitive neuroscience.
Hepatitis C Virus Confirmation in Blood Donor Screening (1993)

A combination of different enzyme immunoassays (EIAs) was used for the serological confirmation of sera that were positive in a hepatitis C virus (HCV) second-generation screening EIA. Different reaction patterns were related with the probability of the HCV-carrier state as determined by polymerase chain reaction (PCR). Five hundred and eight sera of volunteer blood donors were send for confirmation and at first reexamined with both Abbott and Ortho second-generation screening EIA. A group of 195 sera, positive in both assays, was further evaluated by the Abbott Supplemental Assay, the Mono- lisa anti-HCV and an EIA with only the amino terminal part of the nucleo- capsid protein as antigen. In addition PCR on the 5'-noncoding region of the viral genome was performed. We observed that 75 of the 78 PCR-positive sera were found in a group of 89 sera that were strongly positive in the four EIAs used. Moreover all but 1 PCR-positive sera were reactive against the nucleo- capsid protein of the virus. Hence we concluded that a genuine antibody response to the nucleocapsid protein is highly suggestive for the HCV-carrier state.
Protoporphyrin IX in the skin measured noninvasively predicts photosensitivity in patients with erythropoietic protoporphyria (2016)

We have developed a noninvasive method to measure skin PpIX in patients with EPP. Skin PpIX is dependent on erythrocyte PpIX and exposure of the skin to light. This method can be used for objective monitoring of treatment effect.
Ferromagnetism Induced by Intrinsic Defects and Boron Substitution in Single-Wall SiC Nanotubes (2011)

On the basis of density functional theory (DFT) methods, we study the magnetic properties and electronic structures of the armchair (4, 4) and zigzag (8, 0) single-wall SiC nanotubes with various vacancies and boron substitution. The calculation results indicate that a Si vacancy could induce the magnetic moments in both armchair (4, 4) and zigzag (8, 0) single-wall SiC nanotubes, which mainly arise from the p orbital of C atoms surrounding Si vacancy, leading to the ferromagnetic coupling. However, a C vacancy could only bring about the magnetic moment in armchair (4, 4) single-wall SiC nanotube, which mainly originates from the polarization of Si p electrons, leading to the antiferromagnetic coupling. In addition, for both kinds of single-wall SiC nanotubes, magnetic moments can be induced by a boron atom substituting for C atom. When two boron atoms locate nearest neighbored, both kinds of single-wall Si(C, B) nanotubes exhibit antiferromagnetic coupling.
Electrical impedance tomography with cortical or scalp electrodes during global cerebral ischaemia in the anaesthetised rat (1992)

The performance of a prototype impedance imaging (Electrical Impedance Tomography, EIT) system using cortical or scalp electrodes has been assessed in a model of global cerebral ischaemia in the anaesthetised rat. In preliminary calibration experiments using a circular array of electrodes around a tank of saline, the centre of a polythene rod could be localised with a mean error of 4% of the tank diameter, and two such rods could be discriminated when separated by 22% of the tank diameter. Cerebral ischaemia was produced by diathermy of the vertebral arteries and reversible occlusion of the common carotid arteries for 15 min. A bimodal impedance increase of about 50-200% was recorded with a ring of cortical electrodes in the fronto-occipital plane. With a similarly oriented ring of scalp electrodes, a unimodal impedance increase of about 10% was observed. In both cases, impedance reversed after cerebral reperfusion. Similar but irreversible changes were observed post mortem. As the reconstruction algorithm assumes constant initial resistivity, this suggests that modifications to allow for initial conditions would be needed for more accurate imaging with scalp electrodes.