gebhart/patrepeval huggingface dataset:
The Use of Perforated Cellophane for the Growth of Cells in Tissue Culture (1947)

The Use of Perforated Cellophane for the Growth of Cells in Tissue Culture Get access Virginia J. Evans, Virginia J. Evans cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle, Wilton R. Earle principal cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward L. Schilling, Edward L. Schilling technologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Elizabeth P. Wilson, Elizabeth P. Wilson junior cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Emily Duchesne Emily Duchesne junior cytologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 3, December 1947, Pages 103–119, https://doi.org/10.1093/jnci/8.3.103 Published: 01 December 1947 Article history Received: 13 October 1947 Published: 01 December 1947
Improved Pocs-Based Image Reconstruction From Irregularly-Spaced Samples (2002)

Publication in the conference proceedings of EUSIPCO, Toulouse, France, 2002
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial (2005)

Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk.
A new species and the shallowest record of Flabegraviera (Annelida: Flabelligeridae) from Syowa station (2016)

第7回極域科学シンポジウム:[OB] 極域生物圏 11月29日（火）国立極地研究所 1階 交流アトリウム
Potentiation of Anticancer Drugs: Effects of Pentoxifylline on Neoplastic Cells (2011)

The drug efflux activity of P-glycoprotein (P-gp, a product of the mdr1 gene, ABCB1 member of ABC transporter family) represents a mechanism by which tumor cells escape death induced by chemotherapeutics. In this study, we investigated the mechanisms involved in the effects of pentoxifylline (PTX) on P-gp-mediated multidrug resistance (MDR) in mouse leukemia L1210/VCR cells. Parental sensitive mouse leukemia cells L1210, and multidrug-resistant cells, L1210/VCR, which are characterized by the overexpression of P-gp, were used as experimental models. The cells were exposed to 100 μmol/L PTX in the presence or absence of 1.2 μmol/L vincristine (VCR). Western blot analysis indicated a downregulation of P-gp protein expression when multidrug-resistant L1210/VCR cells were exposed to PTX. The effects of PTX on the sensitization of L1210/VCR cells to VCR correlate with the stimulation of apoptosis detected by Annexin V/propidium iodide apoptosis necrosis kit and proteolytic activation of both caspase-3 and caspase-9 monitored by Western blot analysis. Higher release of matrix metalloproteinases (MMPs), especially MMP-2, which could be attenuated by PTX, was found in L1210/VCR than in L1210 cells by gelatin zymography in electrophoretic gel. Exposure of resistant cells to PTX increased the content of phosphorylated Akt kinase. In contrast, the presence of VCR eliminated the effects of PTX on Akt kinase phosphorylation. Taken together, we conclude that PTX induces the sensitization of multidrug-resistant cells to VCR via downregulation of P-gp, stimulation of apoptosis and reduction of MMPs released from drug-resistant L1210/VCR cells. These facts bring new insights into the mechanisms of PTX action on cancer cells.
Zur Kenntnis des dreiwertigen Mangans I (1913)

Abstract Es wurde ein einfaches Verfahren zur Darstellung größerer Mengen von Kaliummanganicyanid K 3 Mn(CN) 6 angegeben. Die Gleichgewichtsverhältnisse bei der Hydrolyse dieses Salzes in wässeriger Lösung wurden untersucht. Die Zersetzung des Kaliummanganicyanids durch vie1 heißes Wasser liefert ein Manganihydroxyd oder ‐oxydhydrat, das sich sehr leicht in konzentrierten Säuren unter Bildung von Manganisalzen auflöst. Das Manganihydroxyd, ‐oxyd‐ hydrat und ‐oxyd muß als Verbindung nur des dreiwertigen Mangans aufgefaßt werden, nicht aber als gemischte Verbindung des zwei‐ und des vierwertigen Mangans.
What the App is That? Deception and Countermeasures in the Android User Interface (2015)

Mobile applications are part of the everyday lives of billions of people, who often trust them with sensitive information. These users identify the currently focused app solely by its visual appearance, since the GUIs of the most popular mobile OSes do not show any trusted indication of the app origin. In this paper, we analyze in detail the many ways in which Android users can be confused into misidentifying an app, thus, for instance, being deceived into giving sensitive information to a malicious app. Our analysis of the Android platform APIs, assisted by an automated state-exploration tool, led us to identify and categorize a variety of attack vectors (some previously known, others novel, such as a non-escapable full screen overlay) that allow a malicious app to surreptitiously replace or mimic the GUI of other apps and mount phishing and click-jacking attacks. Limitations in the system GUI make these attacks significantly harder to notice than on a desktop machine, leaving users completely defenseless against them. To mitigate GUI attacks, we have developed a two-layer defense. To detect malicious apps at the market level, we developed a tool that uses static analysis to identify code that could launch GUI confusion attacks. We show how this tool detects apps that might launch GUI attacks, such as ransom ware programs. Since these attacks are meant to confuse humans, we have also designed and implemented an on-device defense that addresses the underlying issue of the lack of a security indicator in the Android GUI. We add such an indicator to the system navigation bar, this indicator securely informs users about the origin of the app with which they are interacting (e.g., The Pay Pal app is backed by "Pay Pal, Inc."). We demonstrate the effectiveness of our attacks and the proposed on-device defense with a user study involving 308 human subjects, whose ability to detect the attacks increased significantly when using a system equipped with our defense.
A Blockchain-Based Decentralized Data Storage and Access Framework for PingER (2018)

The blockchain is an innovative technology which opened doors to new applications for solving numerous problems in distributed environments. In this work, we design a blockchain-based data storage and access framework for PingER (worldwide end-to-end Internet performance measurement project) to remove its total dependence on a centralized repository. We use the permissioned blockchain and Distributed Hash Tables (DHT) for this purpose. In the proposed framework, metadata of the files are stored on the blockchain whereas the actual files are stored off-chain through DHT at multiple locations using a peer-to-peer network of PingER Monitoring Agents. This will provide decentralized storage, distributed processing, and efficient lookup capabilities to the PingER framework.
A Simplified and Versatile System for the Simultaneous Expression of Multiple siRNAs in Mammalian Cells Using Gibson DNA Assembly (2014)

RNA interference (RNAi) denotes sequence-specific mRNA degradation induced by short interfering double-stranded RNA (siRNA) and has become a revolutionary tool for functional annotation of mammalian genes, as well as for development of novel therapeutics. The practical applications of RNAi are usually achieved by expressing short hairpin RNAs (shRNAs) or siRNAs in cells. However, a major technical challenge is to simultaneously express multiple siRNAs to silence one or more genes. We previously developed pSOS system, in which siRNA duplexes are made from oligo templates driven by opposing U6 and H1 promoters. While effective, it is not equipped to express multiple siRNAs in a single vector. Gibson DNA Assembly (GDA) is an in vitro recombination system that has the capacity to assemble multiple overlapping DNA molecules in a single isothermal step. Here, we developed a GDA-based pSOK assembly system for constructing single vectors that express multiple siRNA sites. The assembly fragments were generated by PCR amplifications from the U6-H1 template vector pB2B. GDA assembly specificity was conferred by the overlapping unique siRNA sequences of insert fragments. To prove the technical feasibility, we constructed pSOK vectors that contain four siRNA sites and three siRNA sites targeting human and mouse β-catenin, respectively. The assembly reactions were efficient, and candidate clones were readily identified by PCR screening. Multiple β-catenin siRNAs effectively silenced endogenous β-catenin expression, inhibited Wnt3A-induced β-catenin/Tcf4 reporter activity and expression of Wnt/β-catenin downstream genes. Silencing β-catenin in mesenchymal stem cells inhibited Wnt3A-induced early osteogenic differentiation and significantly diminished synergistic osteogenic activity between BMP9 and Wnt3A in vitro and in vivo. These findings demonstrate that the GDA-based pSOK system has been proven simplistic, effective and versatile for simultaneous expression of multiple siRNAs. Thus, the reported pSOK system should be a valuable tool for gene function studies and development of novel therapeutics.
Neutralizing Antibodies and Persistence of Immunity following Anthrax Vaccination (2006)

Anthrax toxin consists of protective antigen (PA) and two toxic components, lethal factor (LF) and edema factor (EF). PA binds to mammalian cellular receptors and delivers the toxic components to the cytoplasm. PA is the primary antigenic component of the current anthrax vaccine. Immunity is due to the generation of antibodies that prevent the PA-mediated internalization of LF and EF. In this study, we characterized sera obtained from vaccinated military personnel. Anthrax vaccine is administered in a series of six injections at 0, 2, and 4 weeks and 6, 12, and 18 months, followed by annual boosters. The vaccination histories of the subjects were highly varied; many subjects had not completed the entire series, and several had not received annual boosters. We developed a simple colorimetric assay using alamarBlue dye to assess the antibody-mediated neutralization of LF-mediated toxicity to the J774A.1 murine macrophage cell line. Recently vaccinated individuals had high antibody levels and neutralizing activity. One individual who had not been boosted for 5 years had low immunoglobulin G antibody levels but a detectable neutralization activity, suggesting that this individual produced low levels of very active antibodies.
The Surfactant-Promoted Electroreduction of Oxygen to Hydrogen Peroxide (2005)

The two-electron reduction of at pH 3 (1 M acidified by glacial acetic acid) and 9.6 (mixture of 0.5 M and 0.5 M was investigated in flow-by electrochemical reactors with three-dimensional cathodes, consisting of graphite felt (GF) or reticulated vitreous carbon (RVC). The cathode was operated with co-current upward gas/liquid flow and pressures in the range of 200-700 kPa. A factorial design with four variables at two levels was employed to investigate the effects of superficial current density, liquid load, pressure, and cationic surfactant concentration [i.e., trioctylmethylammonium chloride (Aliquat® 336, A336)] on concentration, current efficiency, and reactor voltage. Among the investigated variables A336 exerted the strongest positive main effect on both concentration and current efficiency. The beneficial effect of A336 was due to suppression of the loss by both electroreduction and surface-catalyzed decomposition. However, A336 increased the pressure gradient through GF by up to 100%. The surfactant effect on the pressure gradient was estimated using the Herbolzheimer-Park model for the influence of surfactant on the motion of gas bubbles in liquid-filled capillaries. An mass-transfer model in both GF and RVC was developed and correlated with the experimental results. © 2005 The Electrochemical Society. All rights reserved.
Gender differences and predictors of workplace deviance behaviour: the role of job stress, job satisfaction and personality on interpersonal and organisational deviance (2014)

This study examined the relationship between job satisfaction, job stress and the big five personality traits on organisational and interpersonal workplace deviance among employees of a construction consultancy organisation in Singapore. Gender differences and organisational tenure differences were also analysed. Results suggest that while job stress directly predicted deviance, job satisfaction did not. Extraversion also had a direct effect on workplace deviance and a significant buffering effect on job stress and interpersonal deviance. Overall, males exhibited higher workplace deviance. Those who have worked for over five years in the company exhibited higher scores on organisational deviance but not interpersonal workplace deviance.
Compounds Related to α-Glycerophosphoric Acid, Phosphorylcholine and Phosphorylethanolamine<sup>1</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCompounds Related to α-Glycerophosphoric Acid, Phosphorylcholine and Phosphorylethanolamine1Arthur F. Rosenthal and Robert P. GeyerCite this: J. Am. Chem. Soc. 1958, 80, 19, 5240–5241Publication Date (Print):October 1, 1958Publication History Published online1 May 2002Published inissue 1 October 1958https://pubs.acs.org/doi/10.1021/ja01552a055https://doi.org/10.1021/ja01552a055research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
NEW SYNTHETIC REACTIONS BASED ON 1-METHYL-2-FLUOROPYRIDINIUM SALTS. STEREOSPECIFIC PREPARATION OF THIOALCOHOLS FROM ALCOHOLS (1977)

Abstract Treatment of various alcohols with 1-methyl-2-fluoropyridinium salt and sodium N,N-dimethyldithiocarbamate afforded alkykl N,N-dimethyldithiocarbamates of inverted configuration. The latter compounds were converted to thioalcohols with retention.
New High Strength Alloys for Brazing with Long Life Corrosion Properties (1997)

<div class="htmlview paragraph">Two newly developed brazing alloys suitable for vacuum brazing (VAC) and controlled atmosphere brazing (CAB), Hogal-3571 and Hogal-3572 respectively, will be presented in this paper. Together with high strength after brazing long life corrosion properties in SWAAT were achieved. Hogal-3571 and 3572 will be compared to other high strength alloys that are already delivered by Hoogovens Aluminium, i.e. Hogai-3570 as well as AA6063 and P.A6060. This paper describes the metallurgical development of the two new brazing alloys. The chemical compositions, the strengthening mechanism, the strength as a function of the cooling rate and the TTP-diagram of the Hogal-3571 alloy will be discussed.</div>
6‐Aza und 7‐azacodeinone (1982)

Abstract Ausgehend von 1a werden durch Ringerweiterungsreaktionen neue N ‐heterocyclische Codeinonderivative erhalten.
Reversal of Experimental Myoglobinuric Acute Renal Failure in Rats by Quercetin, a Bioflavonoid (2004)

The occurrence of acute renal failure (ARF) following rhabdomyolysis has been put at between 10 and 40% of cases, and accounts for between 3 and 15% of all cases of ARF. Reactive oxygen intermediates have been demonstrated to play an etiological role in myoglobinuric renal failure. This study was performed to explore the protective effect of quercetin, a bioflavonoid, in an experimental model of myoglobinuric ARF in rats. Four groups of rats were employed in this study: group 1 served as control, group 2 was given 50% glycerol (8 ml/kg, i.m.), group 3 was given glycerol + quercetin (2 mg/kg, i.p.), and group 4 was given glycerol + DMSO (the solvent for quercetin, 5 ml/kg, i.p.). Renal injury was assessed by measuring serum creatinine, blood urea nitrogen, creatinine and urea clearance. The oxidative stress was measured by renal malondialdehyde levels, reduced glutathione levels and by enzymatic activity of catalase, glutathione reductase, and superoxide dismutase. Glycerol administration resulted in a marked renal oxidative stress, significantly deranged the renal functions as well as renal cytoarchitecture. All these factors were significantly improved by quercetin treatment. Because of its radical-scavenging and iron-chelating properties, quercetin protected the kidney against the glycerol-induced oxidative stress and resultant renal dysfunction. Based on these results, this study confirms the role of oxidative stress and demonstrates the renoprotective potential of quercetin in this rhabdomyolysis-mimicking model.
Regulation of cytokine expression by Schwann cells in response to α<sub>2</sub>‐macroglobulin binding to LRP1 (2011)

Binding of activated α(2)-macroglobulin (α(2)M) to LDL receptor-related protein-1 (LRP1) in Schwann cells activates ERK/MAP kinase and Akt and thereby promotes cell survival and migration. The goal of this study was to determine whether α(2)M binding to LRP1 regulates expression of cytokines and chemokines. To assess the LRP1 response selectively, we studied primary cultures of rat Schwann cells. In a screening assay that detects 84 gene products, monocyte chemoattractant protein-1 (MCP-1/CCL2) mRNA expression was increased more than 13-fold in Schwann cells treated with activated α(2)M. The effects of α(2)M on MCP-1 expression were selective, because expression of the general proinflammatory cytokine tumor necrosis factor-α (TNF-α) was not induced. We confirmed that α(2)M selectively induces expression of MCP-1 and not TNF-α in single-target qPCR assays. MCP-1 protein accumulated at increased levels in conditioned medium of α(2)M-treated cells. LRP1 was necessary for induction of MCP-1 expression, as determined in experiments with the LRP1 antagonist receptor-associated protein, a mutated form of full-length α(2)M that does not bind LRP1, and in studies with Schwann cells in which LRP1 was silenced. Inhibiting ERK/MAP kinase activation blocked expression of MCP-1. These studies support a model in which LRP1 regulates multiple aspects of Schwann cell physiology in the response to PNS injury.
Pulmonary arterial hypertension: pharmacologic therapies and potential pulmonary artery denervation treatment (2013)

Pulmonary arterial hypertension (PAH) is a group of diseases related to progressively increasing pulmonary vascular resistance, a high incidence of right ventricular failure and premature death. Only a limited number of pharmaceutical therapies have proven to be beneficial for PAH. These therapies improve symptoms, exercise capacity, and haemodynamics; however, the clinical relevance of these effects has been challenged. Therefore, the effect of currently approved treatment options remains inconclusive. Conversely, several new drugs for various aetiologies and clinical stages are expected to provide significant advances for the treatment of PAH. Moreover, percutaneous pulmonary artery denervation treatment may lead to a new therapeutic orientation in patients with PAH. The aim of this review is to present the new developments in PAH treatment, provide a brief overview of future directions in the field and discuss the potential future prospects of these innovative therapies.
Simulation and optimized scheduling of pedestrian traffic : from geometric modeling to pedestrian navigation (2007)

Today, more and more simulation tasks with a traditionally non-geometric background need to be embedded into some geometric context, in order to provide spatial context to non-spatial data. This holds especially true for graph-based applications in some location-aware context. As an example, one might think of a theme park or a large commercial center, where the customers shall be provided with some navigation and scheduling information such as where to go and when - either a priori or even in real time via some mobile device. This can be done by analyzing the pedestrian traffic and waiting time situation by simulating the pedestrian movement and using the simulation data to optimally navigate and schedule the tasks that are to be executed by the customer. The main issues addressed in this thesis are as follows. Initially, a flexible simulation framework is built to simulate the pedestrian movement in a 3D scenario, for example, a commercial building. Since the pedestrians strongly interact with the environment surrounding them, the geometry is taken into account. Architectural data such as paths, type and capacity of the paths, destinations and its properties, etc., is extracted from the CAD-model and are organized in a graph structure. The movement of the pedestrians and the waiting queues at the destinations are modeled as queuing systems using the discrete event simulation technique. These queuing systems are then embedded into the geometry model. The necessary input modeling parameters are also defined. The resulting scenario, when simulated, gives an overview of congestions and waiting times across the scenario for different time stages. Apart from the simulation, the geometry data - or here the graph - is hierarchically organized in an octree structure. An octree-based model is chosen since octrees have the natural property of hierarchically storing 3D data. The octree data is used to identify the position of the pedestrian within the scenario. The potential destinations in the neighborhood that can be visited by the customer are also identified using neighbor search algorithms. Combining the simulation data with the octree modeling, the customer is navigated to the optimal destination. Furthermore, when visiting several destinations, combinatorial optimization methods are used to optimally schedule the set of tasks to be executed by the customer. The optimization methods take into account the congestion information obtained from the simulation data, and the octree structure for navigation. This approach results in an effective pedestrian navigation system.