gebhart/patrepeval huggingface dataset:
Modulations of anti‐D affinity following promiscuous binding of the heavy chain with naïve light chains (2003)

The 43F10 anti-D H chain could bind promiscuously to a diversity of L chains from non-D-immunized donors without losing the D-antigen specificity. Relationships between the anti-D affinity and the cationic charge of the L chain as well as with the presence of an arginine residue in the L-chain complementarity-determining region 1 were observed.
Design Considerations When Applying Various LV ASD Topologies to Meet Harmonic Compliance (2011)

To limit the harmonic distortion produced by adjustable speed drives (ASDs), manufacturers have introduced several methods of both passive and active harmonic mitigation. Users of ASDs however, who are faced with the various options often find it difficult to select the most appropriate one for their particular application. Using computer simulation and laboratory measurements, this paper analyzes the most common passive solutions for low voltage (LV) applications which include ac line reactors or dc link chokes, phase shifting to produce multi-pulse ASDs and inline passive harmonic filters. Various design considerations, particularly related to power system parameters, are addressed.
Biomarkers for lung cancer: clinical uses (2007)

Much progress has been made in the last 3 years in the identification and validation of new biomarkers for the early diagnosis of lung cancer. The biomarkers require additional studies before they can be used clinically. Markers to identify lung cancer patients who may benefit from targeted therapy have been developed more rapidly and may be used now in some clinical situations.
Verification of Durability Test Methods of an MEA for Automotive Application (2013)

Potential cycle tests that simulate the operation of a fuel cell vehicle are widely adopted as a durability testing method of membrane-electrode assemblies (MEAs). The Fuel Cell Commercialization Conference of Japan (FCCJ) has proposed methodologies for testing MEAs and their materials in 2007, focusing on the evaluation of the durability of electrode materials. The two protocols, start/stop durability test and load cycle durability test, were revised in 2011 based on the up-to-date knowledge concerning fuel cell durability. In this study, we applied the revised protocols to a standard electrocatalyst, and the effect of the revision was verified. We have demonstrated that the revision of the protocols accelerates the evaluation of fuel cell materials and verified that the revised protocols effectively separate the degradation of Pt electrocatalyst from that of carbon support.
Coupled geomechanics and flow simulation for time-lapse seismic modeling (2004)

Abstract To accurately predict production in compactible reservoirs, we must use coupled models of fluid flow and mechanical deformation. Staggered-in-time loose coupling of flow and deformation via a high-level numerical interface that repeatedly calls first flow and then mechanics allows us to leverage the decades of work put into individual flow and mechanics simulators while still capturing realistic coupled physics. These two processes are often naturally modeled using different time stepping schemes and different spatial grids—flow should only model the reservoir, whereas mechanics requires a grid that extends to the earth's surface for overburden loading and may extend further than the reservoir in the lateral directions. Although spatial and temporal variability between flow and mechanics can be difficult to accommodate with full coupling, it is easily handled via loose coupling. We calculate the total stress by adding pore pressures to the effective rock stress. In turn, changes in volume strain induce updates to porosity and permeability and, hence, dynamically alter the flow solution during simulation. Incorporating the resulting time-dependent pressures, saturations, and porosities (from coupled flow and mechanics) into Gassmann's equations results in seismic wave velocities and densities that can differ markedly from those calculated from flow alone. In a synthetic numerical experiment based on Belridge field, California, incorporation of coupled flow and mechanical deformation into time-lapse calculations produces compressional wave velocities that differ markedly from those produced by flow alone. In fact, it is the closing of the pores themselves (reduction in permeability) in this example which has the greatest impact on fluid pressures and saturations and, hence, elastic wave parameters such as velocity.
Catalysis over Supported Metals. II. The Effect of the Support on the Catalytic Activity of Nickel for Ethane Hydrogenolysis (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis over Supported Metals. II. The Effect of the Support on the Catalytic Activity of Nickel for Ethane HydrogenolysisW. F. Taylor, D. J. C. Yates, and J. H. SinfeltCite this: J. Phys. Chem. 1964, 68, 10, 2962–2966Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://doi.org/10.1021/j100792a038RIGHTS & PERMISSIONSArticle Views247Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (551 KB) Get e-Alerts
Reduction of Inductive Crosstalk Using Quadrupole Inductors (2009)

Interference due to inductor crosstalk is a growing concern in modern RFICs where inductors are placed in close proximity. A quadrupole inductor is explored as a method to reduce inductive crosstalk. A quadrupole inductor and standard inductor are compared with respect to inductance, quality factor, and area. Then, physics-based calculations are corroborated with simulation and measurement to predict crosstalk reduction as a function of position. Measurements verify up to a 31 dB reduction in crosstalk. Finally, phase noise measurements of voltage-controlled oscillators show that the quadrupole inductor can be used in circuits without negatively impacting performance.
Main-chain supramolecular block copolymers (2010)

Block copolymers are key building blocks for a variety of applications ranging from electronic devices to drug delivery. The material properties of block copolymers can be tuned and potentially improved by introducing noncovalent interactions in place of covalent linkages between polymeric blocks resulting in the formation of supramolecular block copolymers. Such materials combine the microphase separation behavior inherent to block copolymers with the responsiveness of supramolecular materials thereby affording dynamic and reversible materials. This tutorial review covers recent advances in main-chain supramolecular block copolymers and describes the design principles, synthetic approaches, advantages, and potential applications.
Combined Quantum Mechanical and Molecular Mechanical Simulations of One- and Two-Electron Reduction Potentials of Flavin Cofactor in Water, Medium-Chain Acyl-CoA Dehydrogenase, and Cholesterol Oxidase (2007)

Flavin adenine dinucleotide (FAD) is a common cofactor in redox proteins, and its reduction potentials are controlled by the protein environment. This regulation is mainly responsible for the versatile catalytic functions of flavoenzymes. In this article, we report computations of the reduction potentials of FAD in medium-chain acyl-CoA dehydrogenase (MCAD) and cholesterol oxidase (CHOX). In addition, the reduction potentials of lumiflavin in aqueous solution have also been computed. Using molecular dynamics and free-energy perturbation techniques, we obtained the free-energy changes for two-electron/two-proton as well as one-electron/one-proton addition steps. We employed a combined quantum mechanical and molecular mechanical (QM/MM) potential, in which the flavin ring was represented by the self-consistent-charge density functional tight-binding (SCC-DFTB) method, while the rest of the enzyme-solvent system was treated by classical force fields. The computed two-electron/two-proton reduction potentials for lumiflavin and the two enzyme-bound FADs are in reasonable agreement with experimental data. The calculations also yielded the pKa values for the one-electron reduced semiquinone (FH*) and the fully reduced hydroquinone (FH2) forms. The pKa of the FAD semiquinone in CHOX was found to be around 4, which is 4 units lower than that in the enzyme-free state and 2 units lower than that in MCAD; this supports the notion that oxidases have a greater ability than dehydrogenases to stabilize anionic semiquinones. In MCAD, the flavin ring interacts with four hydrophobic residues and has a significantly bent structure, even in the oxidized state. The present study shows that this bending of the flavin imparts a significant destabilization (approximately 5 kcal/mol) to the oxidized state. The reduction potential of lumiflavin was also computed using DFT (M06-L and B3LYP functionals with 6-31+G(d,p) basis set) with the SM6 continuum solvation model, and the results are in good agreement with results from explicit free-energy simulations, which supports the conclusion that the SCC-DFTB/MM computation is reasonably accurate for both 1e(-)/1H+ and 2e(-)/2H+ reduction processes. These results suggest that the first coupled electron-proton addition is stepwise for both the free and the two enzyme-bound flavins. In contrast, the second coupled electron-proton addition is also stepwise for the free flavin but is likely to be concerted when the flavin is bound to either the dehydrogenase or the oxidase enzyme.
Huge Intrathoracic Malignant Peripheral Nerve Sheath Tumor in an Adolescent with Neurofibromatosis Type 1 (2014)

Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue malignancy usually found in patients with neurofibromatosis type 1 (NF1) with a poor outcome. Although MPNST can be found in any part of the body including head and neck or extremities, intrathoracic MPNST with or without NF1 is uncommon, especially in children or adolescents. Reported herein is a case of huge intrathoracic MPNST in a 16-year-old girl with NF1, and a brief review of the literature.
Charge Characterization of an Electrically Charged Fiber via Electrostatic Force Microscopy (2006)

The charge of a corona charged electret fiber as well as an uncharged glass fiber was characterized via Electrostatic Force Microscopy (EFM). Electrostatic force gradient images were obtained by monitoring the shifts in phase between the oscillations of the biased EFM cantilever and those of a piezoelectric driver. EFM measurements were performed using noncontact scans at a constant tip-sample separation of 75 nm with varied bias voltages applied to the cantilever. A mathematical expression, based on the Coulombic and induced polarization effects, were used to model the EFM phase shifts as a function of the applied tip bias voltages. There was quantitative agreement between the experimental data and the mathematical expression, and the quantitative interpretation for charges on the fiber was made.
<i>In Vivo</i> Analysis of Schwann Cell Programmed Cell Death in the Embryonic Chick: Regulation by Axons and Glial Growth Factor (2002)

The present study uses the embryonic chick to examine in vivo the mechanisms and regulation of Schwann cell programmed cell death (PCD) in spinal and cranial peripheral nerves. Schwann cells are highly dependent on the presence of axons for survival because the in ovo administration of NMDA, which excitotoxically eliminates motoneurons and their axons by necrosis, results in a significant increase in apoptotic Schwann cell death. Additionally, pharmacological and surgical manipulation of axon numbers also affects the relative amounts of Schwann cell PCD. Schwann cells undergoing both normal and induced PCD display an apoptotic-like cell death, using a caspase-dependent pathway. Furthermore, axon elimination results in upregulation of the p75 and platelet-derived growth factor receptors in mature Schwann cells within the degenerating ventral root. During early development, Schwann cells are also dependent on axon-derived mitogens; the loss of axons results in a decrease in Schwann cell proliferation. Axon removal during late embryonic stages, however, elicits an increase in proliferation, as is expected from these more differentiated Schwann cells. In rodents, Schwann cell survival is regulated by glial growth factor (GGF), a member of the neuregulin family of growth factors. GGF administration to chick embryos selectively rescued Schwann cells during both normal PCD and after the loss of axons, whereas other trophic factors tested had no effect on Schwann cell survival. In conclusion, avian Schwann cells exhibit many similarities to mammalian Schwann cells in terms of their dependence on axon-derived signals during early and later stages of development.
Field Experience With Floodwater Diversion by Complexed Biopolymers (1984)

Due to preferential flow of the injected water through the most permeable zones, waterflooding of stratified reservoirs is generally inefficient. A process for improving the performance of waterfloods in such reservoirs has been developed; it is based on complexing biopolymers with multivalent cations to form gels for selective blocking of water-thief zones, thereby diverting the trailing floodwater to previously under-invaded reservoir regions to recover by-passed oil. This polymeric modification of stratification and of water injection profile leads to increased volumetric sweep of the reservoir by the floodwater and, in turn, to improved oil production. This paper summarizes Mobil's experience in its first seven field projects in Oklahoma using this process. A total of two hundred and five injection wells were treated with complexed biopolymers, resulting in substantial alteration of water flow patterns and in significant incremental oil recovery.
Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma (2014)

Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs). Our aim was to investigate the prevalence of somatic mutations in these genes in unselected patients with APA (n=474), collected through the European Network for the Study of Adrenal Tumors. Correlations with clinical and biochemical parameters were first analyzed in a subset of 199 patients from a single center and then replicated in 2 additional centers. Somatic heterozygous KCNJ5 mutations were present in 38% (180/474) of APAs, whereas ATP1A1 mutations were found in 5.3% (25/474) and ATP2B3 mutations in 1.7% (8/474) of APAs. Previously reported somatic CACNA1D mutations as well as 10 novel CACNA1D mutations were identified in 44 of 474 (9.3%) APAs. There was no difference in the cellular composition of APAs or in CYP11B2, CYP11B1, KCNJ5, CACNA1D, or ATP1A1 gene expression in APAs across genotypes. Patients with KCNJ5 mutations were more frequently female, diagnosed younger, and with higher minimal plasma potassium concentrations compared with CACNA1D mutation carriers or noncarriers. CACNA1D mutations were associated with smaller adenomas. These associations were largely dependent on the population structure of the different centers. In conclusion, recurrent somatic mutations were identified in 54% of APAs. Young women with APAs are more likely to be KCNJ5 mutation carriers; identification of specific characteristics or surrogate biomarkers of mutation status may lead to targeted treatment options.
Conversion between CMYK spaces preserving black separation (2000)

This paper describes a method for developing a transform between two device CMYK spaces in a way that preserves information about the black separation. An important application of such a transform exists in desktop color printers for proofing of electronic files prepared for offset printing.Our method uses a novel printer inversion approach based on constrained optimization. An error function defines the gamut mapping method and black separation behavior. The constraints limit the feasible solution region to the device gamut and prevent exceeding the maximum total area coverage. Colorant values corresponding to in-gamut colors are found with precision limited only by the accuracy of the device model. Out-of-gamut colors are mapped to colors within the boundary of the device gamut. An important property of our method is that areas in the input image using only black ink will be reproduced with the maximum possible black amount for a requested color.We present an application of this method to the creation of multidimensional lookup tables that can be packaged as ICC device link profiles.
Augmentation of Human Immunodeficiency Virus Type 1 Subtype E (CRF01_AE) Multiple-Drug Resistance by Insertion of a Foreign 11-Amino-Acid Fragment into the Reverse Transcriptase (2001)

A human immunodeficiency virus type 1 (HIV-1) subtype E (CRF01_AE) variant (99JP-NH3-II) possessing an in-frame 33-nucleotide insertion mutation in the beta3-beta4 loop coding region of the reverse transcriptase (RT) gene was isolated from a patient who had not responded to nucleoside analogue RT inhibitors. This virus exhibited an extremely high level of multiple nucleoside analog resistance (MNR). Neighbor-joining tree analysis of the pol sequences indicated that the 99JP-NH3-II variant had originated from the swarm of drug-sensitive predecessors in the patient. Population-based sequence analyses of 82 independently cloned RT segments from the patient suggested that the variants with the insertion, three or four 3'-azido-3'-deoxythymidine resistance mutations, and a T69I mutation in combination had strong selective advantages during chemotherapy. Consistently, in vitro mutagenesis of a drug-sensitive predecessor virus clone demonstrated that this mutation set functions cooperatively to confer a high level of MNR without deleterious effects on viral replication capability. Homology modeling of the parental RT and its MNR mutant showed that extension of the beta3-beta4 loop by an insertion caused reductions in the distances between the loop and the other subdomains, narrowing the template-primer binding cleft and deoxynucleoside triphosphate-binding pocket in a highly flexible manner. The origin of the insert is elusive, as every effort to find a homologue has been unsuccessful. Taken together, these data suggest that (i) HIV-1 tolerates in vivo insertions as long as 33 nucleotides into the highly conserved enzyme gene to survive multiple anti-HIV-1 inhibitors and (ii) the insertion mutation augments multiple-drug resistance, possibly by reducing the biochemical inaccuracy of substrate-enzyme interactions in the active center.
The effects of distributed base potential on emitter-current injection density and effective base resistance for stripe transistor geometries (1964)

Simple analytic expressions are derived for the variation of base current, emitter current and emitter-base voltage along the emitter junction of a transistor structure due to the flow of dc base current parallel to the emitter junction. The effective width of the emitter region is discussed, and it is shown that as the emitter width is increased, the effective emitter width approaches a constant value. The change in base resistance with emitter current is also calculated. The use of base contacts on each side of an emitter region is discussed and the analysis is shown to be applicable to this problem for equal or unequal division of base current between the two contacts. The results are applied to a planar transistor structure.
TCR Gene Transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 Epitopes as Melanoma-Specific Immune Targets (2012)

Adoptive therapy with TCR gene-engineered T cells provides an attractive and feasible treatment option for cancer patients. Further development of TCR gene therapy requires the implementation of T-cell target epitopes that prevent "on-target" reactivity towards healthy tissues and at the same time direct a clinically effective response towards tumor tissues. Candidate epitopes that meet these criteria are MAGE-C2(336-344)/HLA-A2 (MC2/A2) and MAGE-A3(243-258)/HLA-DP4 (MA3/DP4). We molecularly characterized TCRαβ genes of an MC2/A2-specific CD8 and MA3/DP4-specific CD4 T-cell clone derived from melanoma patients who responded clinically to MAGE vaccination. We identified MC2/A2 and MA3/DP4-specific TCR-Vα3/Vβ28 and TCR-Vα38/Vβ2 chains and validated these TCRs in vitro upon gene transfer into primary human T cells. The MC2 and MA3 TCR were surface-expressed and mediated CD8 T-cell functions towards melanoma cell lines and CD4 T-cell functions towards dendritic cells, respectively. We intend to start testing these MAGE-specific TCRs in phase I clinical trial.
Pseudomonas Organisms Other than Pseudomonas aeruginosa as Emerging Bacterial Pathogens in Patients with Human Immunodeficiency Virus Infection (2000)

From the Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, Bologna, Italy Address for correspondence: Roberto Manfredi, M.D., Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, Via Massarenti 11, I-40138 Bologna, Italy (Fax: 39 051 34 35 00)
REVIEWS OF MUSIC (1952)

REVIEWS OF MUSIC Get access Five Chinese Lyrics. For High Voice and Piano. By Arthur Oldham. ( Boosey and Hawkes. 4s.) B. W. G. R. B. W. G. R. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XXXIII, Issue 3, July 1952, Pages 273-c–273, https://doi.org/10.1093/ml/XXXIII.3.273-c Published: 01 July 1952
ECG Signal Analysis Using Wavelet Transforms (2008)

Abstract. This paper deals with the study of ECG signals using wavelet trans-form analysis. In the first step an attempt was made to generate ECG wave-forms by developing a suitable MATLAB simulator and in the second step, using wavelet transform, the ECG signal was denoised by removing the corresponding wavelet coefficients at higher scales. Then QRS complexes were detected and each complex was used to find the peaks of the individual waves like P and T, and also their deviations. PACS number: 87.85.J; 02.30.Nw 1