gebhart/patrepeval huggingface dataset:
Using X.500 to Facilitate the Creation of Information Systems Federations (1994)

X.500 is the international standard for a world-wide automated directory system, the Directory, which enables people and automated systems to search for information such as people, places, systems, services, etc. However, much of the information that is expected to be found in the directory already exists in corporate and institutional databases as well as other information sources. In the last ten years or so, computing experts have begun creating federations of information systems in order to give us easier access to a variety of information sources. These range from simple but powerful network grazers like Archie and Veronica to more sophisticated heterogeneous database projects like Interbase, Myriad, ORECOM and others. The issues of interfacing the X.500 Directory with existing information sources are explored-in effect, the X.500 Directory is seen as a federation manager of information systems. In particular, the integration of X.500 methods with relational database technology is studied in the context of what is possible and what makes sense. To test these ideas an existing Directory Service Agent has been modified to access a commercial relational database management system, allowing a directory administrator to map the tuples of a relation into the entries of the directory. Results from this effort have revealed challenges not only in the conceptual design of such a system, such as information schema translation, but also in the pragmatics of system design, such as the registration of external information sources within the Directory itself. Finally, this thesis speculates on the ultimate scope of X.500 as an information systems federation manager, where the global information network could be headed and what we might see or invent along the way.
Acquired Mutations That Affect Pre-mRNA Splicing in Hematologic Malignancies and Solid Tumors (2013)

The application of next-generation sequencing technologies to interrogate the genome of human hematologic malignancies is providing promising insights into their molecular etiology and into the pathogenesis of seemingly unrelated malignancies. Among the somatic mutations identified by this approach are ones that target components of the spliceosome, a ribonucleoprotein complex responsible for the posttranscriptional processing of primary transcripts to form mature messenger RNA species. These mutations were initially detected in patients with chronic lymphocytic leukemia or a myelodysplastic syndrome, but can also occur at relatively high frequency in some solid tumors, including uveal malignant melanoma, adenocarcinoma of the lung, and estrogen receptor-positive breast cancers. Their presence in a variety of malignancies suggests that the spliceosomal mutations may play a fundamental role in defining the malignant phenotype. The development and testing of drugs that eliminate cells bearing a spliceosomal mutation, or normalize their altered transcript splicing patterns, are therefore a priority. Here, we summarize the effects of spliceosome-associated mutations on transcript processing in vitro and in vivo, and their impact on disease initiation and/or progression and patient outcome. Moreover, we discuss the therapeutic potential of compounds already known to target splicing factor 3B subunit 1 (SF3B1), an essential component of the spliceosome that is frequently mutated.
MobHinter (2008)

We focus on collaborative filtering dealing with self-organizing communities, host mobility, wireless access, and ad-hoc communications. In such a domain, knowledge representation and users profiling can be hard; remote servers can be often unreachable due to client mobility; and feedback ratings collected during random connections to other users' ad-hoc devices can be useless, because of natural differences between human beings. Our approach is based on so called Affinity Networks, and on a novel system, called MobHinter, that epidemically spreads recommendations through spontaneous similarities between users. Main results of our study are two fold: firstly, we show how to reach comparable recommendation accuracies in the mobile domain as well as in a complete knowledge scenario; secondly, we propose epidemic collaborative strategies that can reduce rapidly and realistically the cold start problem.
Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. (2002)

Tumors of glial origin such as glioblastoma multiforme (GBM) comprise the majority of human brain tumors. Patients with GBM have a very poor survival rate, with an average life expectancy of <1 year. We asked whether we could identify a survival pathway in high-grade glioma and oligodendroglioma cells that when suppressed, would induce apoptosis of these tumor cells but not of normal human adult astrocytes. To identify these pathways, we selectively suppressed the activity of a number of proteins (Ras, Rac1, Akt1, RhoA, c-jun, and MEK1/2) hypothesized to play roles in cell survival. We found that suppression of Rac1, a small GTP-binding protein, inhibited survival and produced apoptosis in three human glioma cell lines (U87, U343, and U373). Serum induced the activity of Rac1 and the activity or phosphorylation state of p21-activated kinase 1 and c-Jun NH(2)-terminal kinase (JNK), two intracellular targets of Rac1. Suppression of Rac1 also induced apoptosis in 19 of 21 short-term cultures of human primary cells from grades II and III oligodendroglioma and grade IV glioblastoma that varied in p53, epidermal growth factor receptor, epidermal growth factor receptor vIII, MDM2, and p16/p19 mutational or amplification status. In contrast, inhibition of Rac1 activity did not induce apoptosis of normal primary human adult astrocytes. In both established glioma cell lines and primary glioma cells, apoptosis induced by the inhibition of Rac was partially rescued by activated mitogen-activated protein kinase kinase 1, an activator of JNK, suggesting that JNK functions downstream of Rac1 in glioma cells. These results indicate that Rac1 regulates a major survival pathway in most glioma cells, and that suppression of Rac1 activity stimulates the death of virtually all glioma cells, regardless of their mutational status. Agents that suppress Rac1 activity may therefore be useful therapeutic treatments for malignant gliomas.
Hydrogen: its technology and implications. Volume IV. Utilization of hydrogen (1979)

Volume IV covers the present and future uses of hydrogen. Chapters are devoted to: hydrogen-fueled surface transportation; hydrogen-fueled aircraft; domestic uses of hydrogen; industrial applications of hydrogen; and safety.
Seasonal herd dynamics of a savanna elephant population (1984)

Summary The ecology and behaviour of the Amboseli elephant population in southern Kenya has, unlike most populations studied so far, been largely unaffected by human pressures, so provides an opportunity to examine and explain natural seasonal cycles in movement, habitat selectivity and herd dynamics. Water distribution and forage quality largely dictate seasonal migrations. During dry seasons elephants are confined within the vicinity of permanent water and, like the other wild herbivores in the ecosystem, select habitats with progressively more abundant but less digestible forage. Herd size increases spontaneously at the onset of each rains, and declines progressively through the dry season as food reserves diminish. Various hypotheses for the seasonal aggregations are considered, including foraging, social, reproductive and anti‐predator. The evidence is still inadequate to show conclusively whether recent changes in elephant movement result from increased human pressures, or changes in rainfall and food availability. Résumé L'écologie et le comportement de la population d'éléphants de l'Amboseli (S Kenya) a été, au contraite de la plupart de celles étudiées jusqu'ici, épargnée de toute pression anthropique, ce qui a permis d'étudier et de discuter les cycles naturels de mouvements saisonniers, la sélectivité des habitats et la dynamique des populations. La disponibilité en eau et la qualité du fourrage dictent manifestement les migrations saisonnières. Durant la saison sèche les éléphants sont confinés au voisinage des points d'eau permanents et, tout comme les autres herbivores sauvages de cet écosystème, choisissent progressivement des milieux offrant une nourriture plus abondante mais moins digeste. La taille du troupeau augmente spontanément dès la venue des pluies et décroît progressivement au long de la saison sèche lorsque les réserves de nourriture s'amenuisent. Différentes hypothèses quant aux aggrégations saisonnières sont considérées y compris celles relatives au comportement alimentaire, social, reproducteur et défensif. Il n'y a pas encore d'évidence permettant de conclure que les récentes modifications des déplacements sont dues à une pression humaine croissante, une modification des chutes de pluies ou de la disponibilité de nourriture.
A GaN HEMT Gate Driver IC with Programmable Turn-on dV/dt Control (2020)

A programmable slew rate (SR) control by dynamically modulating power supply of GaN HEMT gate drive is proposed in this paper to optimize EMI and efficiency for power converters. This single-channel gate driver has been fabricated in a $0.35 \mu \mathrm{m}$ HV CMOS process, where the active area is $1160\times 1032 \mu \mathrm{m}^{2}$ and V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</inf> regulator ($\approx 937 \times 382 \mu \mathrm{m}^{2}$) has also been implemented to ensure a wide power supply range (6-18V). The proposed high-speed circuit can work up to 2MHz with transmission delay of 11ns and a small gate-drive voltage droop (<0.2V). Moreover, flexible programmable turn-on dV/dt control, which changes by more than 5 times with the help of external resistors, is provided for EMI optimization. This enhancement technique with fast gate drive is especially suited for power module with GaN devices from 100V to 650V voltage range.
First-passage-time moments of Markov processes (1985)

We consider the first-passage times of continuous-time Markov chains. Based on the approach of generalized inverse, moments of all orders are derived and expressed in simple, explicit forms in terms of the ‘fundamental matrix'. The formulas are new and are also efficient for computation.
Testosterone replacement therapy in the climacteric: Benefits beyond sexuality (2009)

Testosterone therapy during menopause has a wide range of benefits that reach beyond the realm of human sexuality. This is a consequence not only of the widespread distribution of androgen receptors in various extragonadal tissues but also of the conversion of androgens to estrogens in the tissues in which aromatase expression is present. For this reason, testosterone therapy during the climacteric years will not only supply androgens but will also stimulate estrogen production in tissues that express aromatase. Furthermore, the bioavailability of androgens to the tissues depends not only on the rate of their production by the postmenopausal ovaries and adrenals but also on the circulating levels of sex hormone-binding globulin (SHBG). Tibolone inhibits SHBG production in the liver, thus increasing free testosterone levels. The association of tibolone with testosterone as a form of androgen replacement therapy during the climacteric is discussed, as is the use of low-dose testosterone, tibolone or the association of both in perimenopausal patients with signs of androgen deficiency. Testosterone treatment has a boosting effect not only on human sexuality but also on the sensation of well-being, a stimulatory effect conferred by the increase in beta-endorphins.
Improved Performance of LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub>Cathodes with Electrolytes Containing Dimethylmethylphosphonate (DMMP) (2012)

The cycling performance of Li/LiNi0.5Mn1.5O 4 cells with 1.0 M LiPF6 in ethylene carbonate (EC)/ethyl methyl carbonate (EMC) (3:7) with and without added dimethyl methylphosphonate (DMMP) (0.5-1.0%) was investigated. Addition of DMMP resulted in improved capacity retention during cycling to high voltage (4.9 V vs Li). Ex-situ surface analysis of LiNi0.5Mn1.5O4 electrodes after cycling via Scanning Electron Microscopy (SEM), X-ray Photoelectron Spectroscopy (XPS) and Infrared (IR) spectroscopy suggest that addition of DMMP inhibits electrolyte decomposition on the surface of the cathode. Addition of DMMP also inhibits the dissolution of Mn from LiNi0.5Mn1.5O 4 particles stored in electrolyte at 85 °C. © 2012 The Electrochemical Society.
Execution performance issues in full-text information retrieval (1995)

The task of an information retrieval system is to identify documents that will satisfy a user's information need. Effective fulfillment of this task has long been an active area of research, leading to sophisticated retrieval models for representing information content in documents and queries and measuring similarity between the two. The maturity and proven effectiveness of these systems has resulted in demand for increased capacity, performance, scalability, and functionality, especially as information retrieval is integrated into more traditional database management environments. In this dissertation we explore a number of functionality and performance issues in information retrieval. First, we consider creation and modification of the document collection, concentrating on management of the inverted file index. An inverted file architecture based on a persistent object store is described and experimental results are presented for inverted file creation and modification. Our architecture provides performance that scales well with document collection size and the database features supported by the persistent object store provide many solutions to issues that arise during integration of information retrieval into more general database environments. We then turn to query evaluation speed and introduce a new optimization technique for statistical ranking retrieval systems that support structured queries. Experimental results from a variety of query sets show that execution time can be reduced by more than 50% with no noticeable impact on retrieval effectiveness, making these more complex retrieval models attractive alternatives for environments that demand high performance.
Production of drug loaded microparticles by the use of supercritical gases with the Aerosol Solvent Extraction System (ASES) process (1996)

The aerosol solvent extraction system (ASES) uses a supercritical gas as non-solvent for an organic solution of drug and polymer in order to form microparticles by a flocculation process. Due to the miscibility of organic solvent and supercritical gas phase, microparticles with residual organic solvents below 30 ppm are formed. This principle was tested to encapsulate model drugs such as hyoscine butylbromide, indomethacin, piroxicam and thymopentin. As a carrier, the polymer poly-L-lactide was used. The resulting microparticles were investigated with regard to particle formation, morphology, particle size, size distribution, and drug loading. With decreasing, polarity of the incorporated drug, an increasing extraction occurs which lowers the drug loading of the microparticles. The extraction capacity of the gas phase depends on temperature and pressure which determines density and polarity of the gas. The obtained results show that the production conditions have to be optimized for each drug/polymer combination. Totally non-polar drugs are completely extracted together with the organic solvent, however, polar drugs, and here especially peptides and proteins, are easy to incorporate with the ASES process.
PROFESORES E INVESTIGADORES DE TIEMPO COMPLETO Y MEDIO TIEMPO EN LA UNAM (1959)

LA GACETA DE LA UNIVERSIDAD PUBLICA UNA SECCION SEMANAL EN DONDE SE DAN LOS DATOS MAS IMPORTANTES DE LAS PERSONAS QUE FORMAN EL CUERPO DE PROFESORES E INVESTIGADORES DE TIEMPO COMPLETO Y DE MEDIO TIEMPO EN LA UNAM. EN ESTA OCASION SE PUBLICAN LOS DATOS CORRESPONDIENTES AL PROFESOR DE MEDIO TIEMPO EN LA FACULTAD DE FILOSOFIA Y LETRAS, FERNANDO WAGNER Y DEL INVESTIGADOR DE TIEMPO COMPLETO EN EL INSTITUTO DE ESTUDIOS MEDICOS Y BIOLOGICOS, DR. CESAR WONG CHIA.
The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy (2011)

Metabolic syndrome refers to a set of conditions that increases the risk of cardiovascular disease and has been associated with an increased risk of prostate cancer, particularly among African American men. This study aimed to estimate the association of metabolic syndrome with biochemical recurrence (BCR) in a racially diverse population. Among 383 radical prostatectomy patients, 67 patients had documented biochemical recurrence. Hypertension was significantly, positively associated with the rate of BCR (hazard ratio (HR) = 2.1; 95% CI = 1.1, 3.8). There were distinct racial differences in the prevalence of individual metabolic syndrome components; however, the observed associations with BCR did not differ appreciably by race. We conclude that hypertension may contribute to a poorer prognosis in surgically treated prostate cancer patients. Our findings suggest that targeting components of the metabolic syndrome which are potentially modifiable through lifestyle interventions may be a viable strategy to reduce risk of BCR in prostate cancer.
Flattening of proton dose distributions for large‐field radiotherapy (1977)

Methods for obtaining flattened charged-particle dose distributions over large areas are described. The system being used at Harvard for proton radiotherapy is discussed in detail. It is an extension of usual multiple-scattering techniques to include blocking out some of the central peak, followed by rescattering to fill in the profile, resulting in flat distributions up to 30 cm in diameter. The unusually long source-to-skin distance (4.6-m SSD) plus the small lateral spread (2 mm rms) from multiple scattering in the patient results in little divergence of the beam throughout the treatment volume.
Transcriptional interference: an unexpected layer of complexity in gene regulation (2007)

Much of the genome is transcribed into long untranslated RNAs, mostly of unknown function. Growing evidence suggests that transcription of sense and antisense untranslated RNAs in eukaryotes can repress a neighboring gene by a phenomenon termed transcriptional interference. Transcriptional interference by the untranslated RNA may prevent recruitment of the initiation complex or prevent transcriptional elongation. Recent work in yeast, mammals, and Drosophila highlights the diverse roles that untranslated RNAs play in development. Previously, untranslated RNAs of the bithorax complex of Drosophila were proposed to be required for its activation. Recent studies show that these untranslated RNAs in fact silence Ultrabithorax in early embryos, probably by transcriptional interference.
Dielectrophoretic Process for Liquid-Liquid Mixing (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDielectrophoretic Process for Liquid-Liquid MixingB. O. HollandCite this: Ind. Eng. Chem. Fundamen. 1966, 5, 2, 204–207Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/i160018a009https://doi.org/10.1021/i160018a009research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Humanized Mice as Unique Tools for Human-Specific Studies (2018)

With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, "humanized" mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans. Currently, literature is rife with descriptions of novel and innovative humanized mouse models that hold a significant promise to become a panacea for drug innovations to treat and control conditions such as infectious disease and cancer. This review will focus on the background of humanized mice, diseases, and human-specific therapeutics tested on this platform as well as solutions to improve humanized mice for future clinical use.
Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta (1994)

Human platelet glycoprotein Ib beta (GPIb beta) (M(r) 22,000) is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor and mediates platelet adhesion in the arterial circulation. The four members of the receptor (GPs Ib alpha, Ib beta, V, and IX) share structural and functional features. Individually, GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. To define the structure of the GPIb beta gene, a cosmid clone from a human genomic library was analyzed. The transcriptional start site was located by both primer extension and the "anchored" polymerase chain reaction. Similar to the genes for Ib alpha, V, and IX, the Ib beta gene is compact with a single 274-base intron inserted into the 5' end of the open reading frame. The 5'-flanking region of the gene contains both GATA and ets sites that are also found in the 5' promoter regions of other described megakaryocyte/platelet genes. The GPIb beta gene was localized to chromosome 22q11.2 by fluorescence in situ hybridization. The GPIb beta gene has a simple structure, similar to that of other described megakaryocyte/platelet genes, including those of the GPIb-V-IX system.
Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea (2010)

A Ce(3+):YAG double-clad crystal fiber (DCF) visible emission was used as the light source for optical coherence tomography (OCT). The visible emission was produced from a 10 microm core DCF pumped by a diode laser. The broadband emission and short central wavelength of this light source enabled the realization of 1.5 microm axial resolution in air. The relatively clean spectrum reduced the side lobe of its point-spread function, and therefore facilitated the generation of a high-quality image with less crosstalk between adjacent image pixels. As a demonstration, an Aplocheilus lineatus goldfish was experimented on to map out the stroma of its cornea. This visible-light-based OCT can be utilized for industrial inspection as well as ocular applications.