gebhart/patrepeval huggingface dataset:
Immunologic suppression after oral administration of antigen. II. Antigen-specific helper and suppressor factors produced by spleen cells of rats fed sheep erythrocytes. (1980)

Abstract Spleen cells from rats given sheep erythrocytes (SRBC) orally were cultured for 48 hr in the presence of SRBC. The supernatant of this culture was found to have two SRBC-specific activities, one that helped and one that suppressed the in vitro antibody (PFC) response to the specific antigen. Neither factor affected the response to horse erythrocytes. The helper factor, THF, has a m.w. of 30 to 45 × 103 and appears to act only on syngeneic cells. The suppressor factor, TSF, has a m.w. of 60 to 75 × 103 daltons and suppressed the PFC response of three allogeneic strains differing at AgB. THF was not produced by cells of donors thymectomized as adults and then fed SRBC, but its production was inhibited by treatment of fed animals with anti-lymphocyte serum (ALS), whereas production of TSF was inhibited by ALS treatment and unaffected by thymectomy of the donors. THF enhanced the PFC response of cultures when added at any time in the first 72 hr, whereas TSF produced a maximal suppressive effect only if added in the first 24 hr. THF helper activity was expressed only in the presence of intact T cells. In the whole supernatants, TSF shows a dominance in activity over THF, since suppression is always obtained by using the unfractioned supernatants.
Structure–Activity Analysis of the Growth Hormone Secretagogue GHRP‐6 by α‐ and β‐Amino γ‐Lactam Positional Scanning (2009)

Incorporation of amino lactams into biologically active peptides restricts conformational mobility and may enhance selectivity and increase potency. alpha- and beta-amino gamma-lactams (Agl and Bgl), in both S and R configurations, were introduced into the growth hormone secretagogue GHRP-6 using a Fmoc-compatible solid-phase protocol relying on N-alkylation with five- and six-membered cyclic sulfamidates, followed by lactam annulation under microwave heating. Using this protocol in conjunction with IRORI Kan techniques furnished eleven new GHRP-6 analogs, and their binding affinity IC50 values on both the growth hormone secretagogue receptor 1a (GHS-R1a) and CD36 receptors are herein reported. The results indicate that selectivity towards one receptor or the other can be modulated by lactam substitution, typically at the Ala3 and the D-Phe5 positions.
Gamma- and X-Ray Spectrometry with Semiconductor Detectors (1988)

Preface. Introduction. 1. Background material. 2. Experimental setup. 3. Spectrum analysis and energy measurements. 4. Efficiency calibration and emission-rate measurements. 5. Applications. 6. Atomic and nuclear data. References. Indexes.
Superparamagnetic Nanocomposites of Poly(vinyl alcohol‐<i>graft</i>‐acrylonitrile) as Carrier for Magnetically Assisted Release of Ciprofloxacin (2012)

Abstract In the present study also a superparamagnetic nanocomposite of Poly (vinyl‐ alcohol‐g‐acrylonitrile) has been designed by homogeneous impregnation of iron oxide nanoparticles into the graft polymer matrix. The so prepared nanocomposite was characterized by FT‐IR, TEM and XRD techniques and studied for water sorption behavior and magnetization properties. The superparamagnetic nanocomposite was loaded with an antibiotic drug, ciprofloxacin (CFx), and its release behavior was investigated under varying experimental conditions such as chemical composition of the matrix, pH of the release media, applied magnetic field and percent loading of the drug. The drug transport mechanism was also analyzed using Ficks power law. The drug loaded magnetic nanocomposite was also studied for antibacterial and in‐vitro blood compatible properties.
The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control (2013)

A familial form of Amyotrophic lateral sclerosis (ALS8) is caused by a point mutation (P56S) in the vesicle-associated membrane protein associated protein B (VapB). Human VapB and Drosophila Vap-33-1 (Vap) are homologous type II transmembrane proteins that are localized to the ER. However, the precise consequences of the defects associated with the P56S mutation in the endoplasmic reticulum (ER) and its role in the pathology of ALS are not well understood. Here we show that Vap is required for ER protein quality control (ERQC). Loss of Vap in flies shows various ERQC associated defects, including protein accumulation, ER expansion, and ER stress. We also show that wild type Vap, but not the ALS8 mutant Vap, interacts with a lipid-binding protein, Oxysterol binding protein (Osbp), and that Vap is required for the proper localization of Osbp to the ER. Restoring the expression of Osbp in the ER suppresses the defects associated with loss of Vap and the ALS8 mutant Vap. Hence, we propose that the ALS8 mutation impairs the interaction of Vap with Osbp, resulting in hypomorphic defects that might contribute to the pathology of ALS8.
Homotopy continuation for sparse signal representation (2006)

We explore the application of a homotopy continuation-based method for sparse signal representation in overcomplete dictionaries. Our problem setup is based on the basis pursuit framework, which involves a convex optimization problem consisting of terms enforcing data fidelity and sparsity, balanced by a regularization parameter. Choosing a good regularization parameter in this framework is a challenging task. We describe a homotopy continuation-based algorithm to find and trace efficiently all solutions of basis pursuit as a function of the regularization parameter. In addition to providing an attractive alternative to existing optimization methods for solving the basis pursuit problem, this algorithm can also be used to provide an automatic choice for the regularization parameter, based on prior information about the desired number of non-zero components in the sparse representation. Our numerical examples demonstrate the effectiveness of this algorithm in accurately and efficiently generating entire solution paths for basis pursuit, as well as producing reasonable regularization parameter choices. Furthermore, exploring the resulting solution paths in various operating conditions reveals insights about the nature of basis pursuit solutions.
Schwann Cells Express Motor and Sensory Phenotypes That Regulate Axon Regeneration (2006)

Schwann cell phenotype is classified as either myelinating or nonmyelinating. Additional phenotypic specialization is suggested, however, by the preferential reinnervation of muscle pathways by motoneurons. To explore potential differences in growth factor expression between sensory and motor nerve, grafts of cutaneous nerve or ventral root were denervated, reinnervated with cutaneous axons, or reinnervated with motor axons. Competitive reverse transcription-PCR was performed on normal cutaneous nerve and ventral root and on graft preparations 5, 15, and 30 d after surgery. mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1 was expressed vigorously by denervated and reinnervated cutaneous nerve but minimally by ventral root. In contrast, mRNA for pleiotrophin (PTN) and glial cell line-derived neurotrophic factor was upregulated to a greater degree in ventral root. ELISA confirmed that NGF and BDNF protein were significantly more abundant in denervated cutaneous nerve than in denervated ventral root, but that PTN protein was more abundant in denervated ventral root. The motor phenotype was not immutable and could be modified toward the sensory phenotype by prolonged reinnervation of ventral root by cutaneous axons. Retrograde labeling to quantify regenerating neurons demonstrated that cutaneous nerve preferentially supported cutaneous axon regeneration, whereas ventral root preferentially supported motor axon regeneration. Schwann cells thus express distinct sensory and motor phenotypes that are associated with the support of regeneration in a phenotype-specific manner. These findings suggest that current techniques of bridging gaps in motor and mixed nerve with cutaneous graft could be improved by matching axon and Schwann cell properties.
Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients. (1981)

THA, a centrally acting anticholinesterase, was given intravenously in varying doses to 12 unselected cases of Alzheimer-like senile dementia. Significant improvement in memory testing occurred in 6 of 12 subjects; 9 of 12 improved in clinical staging. Analysis of results with respect to staging of dementia revealed that the degree of improvement was inversely related to the severity of dementia. Statistical analysis of these data by the Friedman test is detailed.
Factors affecting charge separation and recombination in photoexcited rigid donor-insulator-acceptor compounds (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors affecting charge separation and recombination in photoexcited rigid donor-insulator-acceptor compoundsMichael N. Paddon-Row, Anna M. Oliver, John M. Warman, Kenneth J. Smit, Matthijs P. De Haas, Henk Oevering, and Jan W. VerhoevenCite this: J. Phys. Chem. 1988, 92, 24, 6958–6962Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/j100335a024https://doi.org/10.1021/j100335a024research-articleACS PublicationsRequest reuse permissionsArticle Views321Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Prairie Provinces in their Relation to the National Economy of Canada: A Statistical Study of their Social and Economic Condition in the Twentieth Century. (Canada, Dominion Bureau of Statistics.) Ottawa: 1934. Pp. 153 (planographed). - A Decade of Retail Trade, 1923-1933. (Canada, Dominion Bureau of Statistics.) Ottawa: 1935. Pp. 31 (mimeo.). - Recent Economic Tendencies in Canada, 1919-1934, showing Annual Average Percentage Changes with Illustrative Charts. (Canada, Dominion Bureau of Statistics.) Ottawa: 1935. Pp. 142 (planographed). (1936)

The Prairie Provinces in their Relation to the National Economy of Canada: A Statistical Study of their Social and Economic Condition in the Twentieth Century. (Canada, Dominion Bureau of Statistics.) Ottawa: 1934. Pp. 153 (planographed). - A Decade of Retail Trade, 1923-1933. (Canada, Dominion Bureau of Statistics.) Ottawa: 1935. Pp. 31 (mimeo.). - Recent Economic Tendencies in Canada, 1919-1934, showing Annual Average Percentage Changes with Illustrative Charts. (Canada, Dominion Bureau of Statistics.) Ottawa: 1935. Pp. 142 (planographed). - Volume 2 Issue 2
Minimizing Electrode Motion Artifact by Skin Abrasion (1977)

Motion artifacts frequently cause erroneous results in biopotential measurement. When surface electrodes and conducting paste are used, a major cause of motion artifact is change in skin potential. The most effective means of minimizing this artifact is light abrasion of the sidn with fine sandpaper. A very mild paste is then required to avoid skin irritation.
Draftsman Displays, A Graphical Technique for Exploratory Data Analysis. (1984)

This thesis develops and explores the graphical analysis of multivariate data sets through the use of a Draftsman technique of scatter plot displays. These plot displays are useful for determining associations and relationships between variables in order to promote an understanding of the characteristics of the data in exploratory and descriptive applications. General graphical enhancement techniques such as jittering and transformations are discussed and incorporated in the development of a computer program which produces Draftsman displays. A technical description of the Draftsman computer program is presented, and user implementation procedures discussed. An analysis is conducted on two varied sets of data to demonstrate the versatility and utility of the Draftsman display technique for exploring data structures.
A replicated, distributed file system (1986)

This paper discusses IBIS-RP, the prototype of a distributed file and directory system with demand replication. Demand replication Is a self-adapting replication scheme. Each object (file or directory) consIsts of a primary copy and a possibly empty set of read-only, secondary copies at different sites. The first read operation on an object issued at a site without the primary copy creates a secondary copy at that site; all further reads at that site use the local replica, until it is outdated. Write operations modify the primary copy, and have the side effect of outdatlng the replicas.
Changes in Soil Properties Under Annual Applications of Feedlot Manure and Different Tillage Practices (1985)

Abstract A long‐term manure study was set up in which cattle feedlot manure was applied annually at four rates to nonirrigated and irrigated land and was incorporated into the soil by plow, rototiller, or cultivator. The soil is a Dark Brown Chernozem (Typic Haploborolls) at the Lethbridge Research Station. The effects of the manure, incorporated by different methods, on the physical properties and organic matter content of the soil were determined. On both nonirrigated and irrigated land, the soil organic matter content of the surface 0 to 15 cm increased with increasing rates of manure application. Spring‐time soil temperatures, at 8‐cm depth, were coldest where the highest rate of manure had been incorporated. Drawbar draft decreased with increasing rates of manure application. Similarly, bulk density of the surface 0 to 15 cm of soil decreased with increasing rates of manure application, the greatest effect being where the manure had been incorporated by cultivator on irrigated land. But, at 15 to 30‐cm depth, the smallest bulk density was where the manure had been incorporated by plow. Increasing rates of manure on irrigated land tended to decrease the amount of aggregates < 1 mm and increase the amount > 1 mm in size, at the 15 to 30‐cm depth. These results indicate that manure, applied at the relatively low rates that are currently recommended, can maintain and increase the organic matter content of the soil and ameliorate the physical condition of southern Alberta soils.
Evaluation of F-Specific RNA Bacteriophage as a Candidate Human Enteric Virus Indicator for Bivalve Molluscan Shellfish (2000)

Escherichia coli is a widely utilized indicator of the sanitary quality of bivalve molluscan shellfish sold for human consumption. However, it is now well documented that shellfish that meet the E. coli standards for human consumption may contain human enteric viruses that cause gastroenteritis and hepatitis. In this study we investigated using F-specific RNA bacteriophage (FRNA bacteriophage) to indicate the likely presence of such viruses in shellfish sold for consumption. FRNA bacteriophage and E. coli levels were determined over a 2-year period for oysters (Crassostrea gigas) harvested from four commercial sites chosen to represent various degrees of sewage pollution. Three sites were classified as category B sites under the relevant European Community (EC) Directive (91/492), which required purification (depuration) of oysters from these sites before sale. One site was classified as a category A site, and oysters from this site could be sold directly without further processing. Samples were tested at the point of sale following commercial processing and packaging. All of the shellfish complied with the mandatory EC E. coli standard (less than 230 per 100 g of shellfish flesh), and the levels of contamination for more than 90% of the shellfish were at or below the level of sensitivity of the assay (20 E. coli MPN per 100 g), which indicated good quality based on this criterion. In contrast, FRNA bacteriophage were frequently detected at levels that exceeded 1,000 PFU per 100 g. High levels of FRNA bacteriophage contamination were strongly associated with harvest area fecal pollution and with shellfish-associated disease outbreaks. Interestingly, FRNA bacteriophage contamination exhibited a marked seasonal trend that was consistent with the trend of oyster-associated gastroenteritis in the United Kingdom. The correlation between FRNA bacteriophage contamination and health risk was investigated further by using a reverse transcription-PCR assay for Norwalk-like virus (NLV). NLV contamination of oysters was detected only at the most polluted site and also exhibited a seasonal trend that was consistent with the trend of FRNA bacteriophage contamination and with the incidence of disease. The results of this study suggest that FRNA bacteriophage could be used as viral indicators for market-ready oysters.
Highly fluxional arene cyclooctatetraene complexes of zerovalent iron, ruthenium, and osmium. Single-crystal x-ray study of (cyclooctatetraene)(hexamethylbenzene)ruthenium(0), Ru(.eta.6HMB)(1-4-.eta.-COT) (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly fluxional arene cyclooctatetraene complexes of zerovalent iron, ruthenium, and osmium. Single-crystal x-ray study of (cyclooctatetraene)(hexamethylbenzene)ruthenium(0), Ru(.eta.6HMB)(1-4-.eta.-COT)M. A. Bennett, T. W. Matheson, G. B. Robertson, A. K. Smith, and P. A. TuckerCite this: Inorg. Chem. 1980, 19, 4, 1014–1021Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ic50206a045https://doi.org/10.1021/ic50206a045research-articleACS PublicationsRequest reuse permissionsArticle Views1123Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Characterization of the Coronavirus M Protein and Nucleocapsid Interaction in Infected Cells (2000)

Coronavirus contains three envelope proteins, M, E and S, and a nucleocapsid, which consists of genomic RNA and N protein, within the viral envelope. We studied the macromolecular interactions involved in coronavirus assembly in cells infected with a murine coronavirus, mouse hepatitis virus (MHV). Coimmunoprecipitation analyses demonstrated an interaction between N protein and M protein in infected cells. Pulse-labeling experiments showed that newly synthesized, unglycosylated M protein interacted with N protein in a pre-Golgi compartment, which is part of the MHV budding site. Coimmunoprecipitation analyses further revealed that M protein interacted with only genomic-length MHV mRNA, mRNA 1, while N protein interacted with all MHV mRNAs. These data indicated that M protein interacted with the nucleocapsid, consisting of N protein and mRNA 1, in infected cells. The M protein-nucleocapsid interaction occurred in the absence of S and E proteins. Intracellular M protein-N protein interaction was maintained after removal of viral RNAs by RNase treatment. However, the M protein-N protein interaction did not occur in cells coexpressing M protein and N protein alone. These data indicated that while the M protein-N protein interaction, which is independent of viral RNA, occurred in the M protein-nucleocapsid complex, some MHV function(s) was necessary for the initiation of M protein-nucleocapsid interaction. The M protein-nucleocapsid interaction, which occurred near or at the MHV budding site, most probably represented the process of specific packaging of the MHV genome into MHV particles.
Thermophysical Properties of Matter - The TPRC Data Series. Volume 3. Thermal Conductivity - Nonmetallic Liquids and Gases (1970)

Abstract : The TPRC Data Series published in 13 volumes plus a Master Index volume constitutes a permanent and valuable contribution to science and technology. This 17,000 page Data Series should form a necessary acquisition to all scientific and technological libraries and laboratories. These volumes contain an enormous amount of data and information for thermophysical properties on more than 5,000 different materials of interest to researchers in government laboratories and the defense industrial establishment. Volume 3 in this 14 volume TPRC Data Series covers nonmetallic pure substances and mixtures which are in the fluid state at normal temperature and pressure, including 12 elements (plus two isotopes of hydrogen), 10 inorganic compounds, 33 organic compounds, 82 binary systems, 23 ternary systems, and eight systems with more than three components. For the elements, recommended thermal conductivity values are presented for solid, saturated liquid, saturated vapor, and gaseous states. For the other pure substances, recommended values are presented for saturated liquid and gaseous states for fluid mixtures, graphically smoothed values are given in addition to the original experimental data.
Simulation of magnetic aftereffect in particulate recording media (1991)

Employing a numerical integration of the Landau-lifshitz-Gilbert equation for phenomena with nanosecond characteristic times and a Monte Carlo method for much longer time periods, the authors have developed a method that in practice allows efficient simulation of magnetic aftereffect in an assembly of interacting particles for any time length of practical interest. Each particle is assumed to behave according to the Stoner-Wohlfarth model with its easy axis pointing in an arbitrary direction; thus the reversible component of magnetization change is incorporated in magnetic aftereffect studies. This simulation method was implemented on a workstation, and the hysteresis loops of the granular Fe(SiO/sub 2/) thin film material with a sweep time of 10 minutes were calculated with magnetic aftereffect. The thermal broadening of a demagnetization-limited written transition was simulated for the same material. After a sharp transition was created in the center of an assembly of particles, the change in the transition width over 100 seconds was studied.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>