gebhart/patrepeval huggingface dataset:
Octreotide in the treatment of bleeding due to angiodysplasia of the small intestine. (1993)

Three patients with a history of bleeding due to small bowel angiodysplasia (repeated melena or occult fecal blood with serious anemia) were treated for 10-40 months with octreotide, a somatostatin analog that reduces the splanchnic flow. A dose of 0.1 mg subcutaneously twice a day was followed by an increase in hemoglobin, and reduction or elimination of the need for transfusions. There were no further melena episodes, and stool hemoglobin became stably negative in two cases. Suspension of the drug after 6 months in one case was followed by renewed bleeding, and resumption led to a further response. Lower doses tried in another case were ineffective. Although these uncontrolled clinical cases do not prove its efficacy, octreotide appears to be beneficial in the control and prevention of bleeding due to diffuse small bowel angiodysplasia. There is no evidence that it results in regression of angiodysplasias, as they persisted in the patient subjected to control jejunoileoscopy.
News from Hell (1943)

A panoramic view of hell's in training, After the style of Virgil, and of Homer, So that my name of Epic's no misnomer. The extraordinary voyage and the journey to the moon, types of voyages imaginaires popular in French and English literature of the seventeenth and eighteenth centuries, are now recognized literary types, and their interesting connections with the development of science and of poetry have been studied. Another kind of imaginary voyage merits attention, one that goes back not only to Lucian, the grand parent of most of these fantasies, but still farther to that remote time when man, having evolved the idea of a world of life after death, first thought with an archaic grin of the discomfort his enemies might feel when they were sent by Death to his realm of shades and skeletons.
Effect of Solvent and Temperature on Secondary and Tertiary Structure of Zein by Circular Dichroism (2007)

ABSTRACT Circular dichroism studies were performed on zein to determine how the secondary and tertiary structure changes with different solvents, temperatures, or pH. Alcoholic solvent type and common denaturants such as SDS and low amounts of urea had little effect on the secondary structure of zein. Utilization of dimethylformamide or acetic acid as solvent gave changes in tertiary structure. Solutions of zein in 8 M urea produced solutions with large changes in tertiary structure. The dissolution of zein in 50 m M sodium hydroxide produces a zein with large changes in secondary and tertiary structure and little loss in primary structure. Increasing the temperature of zein to 70°C in 80% ethanol‐water gave reversible changes in the primary structure (20% reduction in absolute magnitude of [θ]λ at 208 and 222 nm) and tertiary structure (40% reduction in absolute magnitude of [θ]λ at 268 nm).
mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex (2019)

Phagocytosis is a cellular process crucial for recognition and removal of apoptotic cells and foreign particles, subsequently initiating appropriate immune responses. The process of phagocytosis is highly complex and involves major rearrangements of the cytoskeleton. Due to its complexity and importance for tissue homoeostasis and immune responses, it is tightly regulated. Over the last decade, microRNAs (miRNAs) have emerged as important regulators of biological pathways including the immune response by fine-tuning expression of gene regulatory networks. In order to identify miRNAs implicated in the regulation of phagocytosis, a systematic screening of all currently known, human miRNAs was performed using THP-1 macrophage-like cells and serum-opsonized latex beads. Of the total of 2,566 miRNAs analyzed, several led to significant changes in phagocytosis. Among these, we validated miR-124-5p as a novel regulator of phagocytosis. Transfection with miR-124-5p mimics reduced the number of phagocytic cells as well as the phagocytic activity of phorbol-12-myristate-13-acetate (PMA)-activated THP-1 cells and <i>ex vivo</i> differentiated primary human macrophages. <i>In silico</i> analysis suggested that miR-124-5p targets genes involved in regulation of the actin cytoskeleton. Transcriptional analyses revealed that expression of genes encoding for several subunits of the ARP2/3 complex, a crucial regulator of actin polymerization, is reduced upon transfection of cells with miR-124-5p. Further <i>in silico</i> analyses identified potential binding motifs for miR-124-5p in the mRNAs of these genes. Luciferase reporter assays using these binding motifs indicate that at least two of the genes (<i>ARPC3</i> and <i>ARPC4</i>) are direct targets of miR-124-5p. Moreover, ARPC3 and ARPC4 protein levels were significantly reduced following miR-124-5p transfection. Collectively, the presented results suggest that miR-124-5p regulates phagocytosis in human macrophages by directly targeting expression of components of the ARP2/3 complex.
450 GHz millimetre-wave signal from frequency tripler with heterostructure barrier varactors on gold substrate (2002)

The fabrication technique and measurement of whisker-contacted heterostructure barrier varactors on gold substrate is reported. The gold substrate provides reduced parasitic losses and improved heatsink capabilities, which increase the efficiency of the frequency multipliers based on these devices. Preliminary measurements have shown an output power of 80 µW and efficiency of 0.05% at an output frequency of 450 GHz.
Reverse Query Processing (2007)

Generating databases for testing database applications (e.g., OLAP or business objects) is a daunting task in practice. There are a number of commercial tools to automatically generate test databases. These tools take a database schema (table layouts plus integrity constraints) and table sizes as input in order to generate new tuples. However, the databases generated by these tools are not adequate for testing a database application. If an application query is executed against such a synthetic database, then the result of that application query is likely to be empty or contain weird results, such as a report on the performance of a sales person that contains negative sales. To solve this problem, this paper proposes a new technique called reverse query processing (RQP). RQP gets a query and a result as input and returns a possible database instance that could have produced that result for that query. RQP also has other applications; most notably, testing the performance of DBMS and debugging SQL queries.
Fiber delay lines optical buffer for ATM photonic switching applications (2002)

An optical buffer shift register based on a set of fiber delay lines is presented, with the goal of providing cell storage and queuing in asynchronous transfer mode (ATM) photonic switches. The concept of multiwavelength cell buffering is adopted, to realize a shared buffer with a storage capacity equivalent to a set of shift registers. Since only one wavelength-encoded cell must enter one delay line at each time slot, contention resolution is necessary to determine the queuing order between the incoming cells. The use of optical fibers as delay lines and semiconductor optical amplifiers as gates associated with passive splitters to realize buffering and time-switching has been demonstrated. An experimental setup has been implemented at 600 Mb/s and operates without guard bands between packets. The low penalty observed shows that system synchronization and reliability are good.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multiple-zone single-mask junction termination extension&#8212;A high-yield near-ideal breakdown voltage technology (1987)

The junction termination extension (JTE) technique of Temple is investigated in detail by computer simulation and experimentally. A multiple-zone JTE can be fabricated with a well-controlled single ion-implantation through a single mask with laterally variable transparencies. Analog I-V trace records of over 40 000 samples were obtained for analysis. By grouping 49 JTE designs onto region of the wafer, the effects of the JTE variations and the material variations are separated. The JTE performance agrees well with the computer results. The multiple-zone JTE of sufficient extension size achieves an essentially ideal breakdown voltage unaffected by even a factor of two in ion-implant dose variations. The JTE performs well on both n- and p-type wafers. A best design has been applied to several lots of power devices, and a yield of 99.5 percent having breakdown-voltage values within 10 percent of the ideal has been obtained. The single-mask technique assures the producibility of this 100-percent guard JTE technology, which consumes only 30 percent of the extension area needed by field rings that, at best, produced about 70 percent of the ideal breakdown voltage.
Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo (2011)

ERK-mediated suppression of Nrf2 activity leads to the oxidative stress-induced insulin resistance in adult cardiomyocytes and downregulated glucose utilization in the diabetic heart.
Accurate wide-range displacement measurement using tunable diode laser and optical frequency comb generator (2006)

A laser-frequency-based displacement measurement system with sub-nanometer uncertainty using an optical frequency comb generator is developed. In this method, the optical frequency of a tunable laser is locked to the resonance of a Fabry-Perot cavity. One of the two mirrors of this Fabry-Perot cavity is connected to the element whose displacement is to be measured. Wide range optical frequency and displacement measurements were realized by using an optical frequency comb generator, which consists of an electro-optic modulator placed inside of an optical resonator. We demonstrate a displacement measurement of up to 10 mum with 220 pm uncertainty under the stable condition.
Thyrotropin-releasing hormone in schizophrenia (1975)

Oral administration of thyrotropin-releasing hormone (TRH) caused deterioration in the clinical status of seven out of nine schizophrenic men. This change was particularly apparent in the four patients diagnosed as paranoid schizophrenics. Such changes might be expected from a drug with properties similar to amphetamine.
Can nursing lead care? (1991)

Geoffrey Hunt, the health service's first full-time philosopher, introduces himself and his work
Role for Macrophage Inflammatory Protein 2 (MIP-2), MIP-1α, and Interleukin-1α in the Delayed-Type Hypersensitivity Response to Viral Antigen (2002)

BALB/c mice sensitized to herpes simplex virus type 1 (HSV-1) develop a vigorous delayed-type hypersensitivity (DTH) response upon intradermal virus antigen challenge. Although CD4(+) T cells are a key mediator of this response, neutrophils are the most abundant cells at the antigen challenge site both initially and at the peak of the reaction. We investigated what role, if any, neutrophils play in the DTH to a viral antigen. We show here that antibody-mediated depletion of neutrophils 1 day before antigen challenge significantly suppressed ear swelling and markedly reduced cellular influx. Additionally, neutrophil depletion was associated with decreased expression of macrophage inflammatory protein 2 (MIP-2) and MIP-1alpha, as well as with a >60-fold increase in HSV-1 replication. Neutralizing antibodies to neutrophil chemoattractants MIP-2 or MIP-1alpha but not KC significantly suppressed DTH and sharply reduced neutrophil accumulation in the ear pinna. Purified bone marrow-derived neutrophils exposed to interleukin-1alpha (IL-1alpha) produced chemokines in an 8-h assay. Administration of neutralizing antibody to IL-1alpha significantly reduced ear swelling and suppressed the levels of MIP-2, MIP-1alpha, MIP-1beta, and RANTES. We conclude that neutrophils are a critical component of the DTH response to viral antigen. They are recruited to the DTH test site by MIP-2 and MIP-1alpha, where they can be activated by IL-1alpha. The infiltrating cells also help suppress virus replication in immunized mice.
Comparison of a Recombinant Thromboplastin with Thrombotest® for Oral Anticoagulant Control (1996)

Thrombotest results expressed in international normalized ratio (INR) values, obtained in 108 patients on oral anticoagulant treatment, were compared with prothrombin time (PT) results with a recombinant thromboplastin. The former results were obtained on an Amelung coagulometer, the latter on a photo-optical instrument. Using the Thrombotest method, performed within 2 h after sampling as the reference method, a first group of 63 patients had an INR value between 2 and 4. This group was considered as adequately anticoagulated and served as a true positive population in further analysis. The remaining 45 patients (true-negative group) had an INR value below 2 or higher than 4 and could thus be considered as inadequately anticoagulated. Using these definitions, a sensitivity of 86% and a specificity of 96% could be calculated for the PT with the recombinant thromboplastin. All tests from patients on oral anticoagulant treatment were also performed after 24 h storage of the blood or plasma samples at room temperature. When we compared the reference Thrombotest results with those of the late Thrombotest and the late PT recombinant thromboplastin, sensitivities of 86 and 86% as well as specificities of 91 and 96% were found, respectively. In conclusion, PT with a recombinant thromboplastin on a photo-optical instrument, even after prolonged storage of the plasma samples at room temperature, can be considered as suitable for oral anticoagulation control.
Potential Dependent Dual Ion Transport of Conducting Polymer: Redox Polymer Bilayers (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential Dependent Dual Ion Transport of Conducting Polymer: Redox Polymer BilayersMyoungho Pyo and John R. ReynoldsCite this: J. Phys. Chem. 1995, 99, 20, 8249–8254Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/j100020a057https://doi.org/10.1021/j100020a057research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A Design of a High-Speed and High-Efficiency Capsule Endoscopy System (2011)

This paper presents a high-speed and high-efficiency capsule endoscopy system. Both a transmitter and a receiver were optimized for its application through an analysis of the human body channel. ON-OFF keying modulation is utilized to achieve low power consumption of the in-body transmitter. A low drop output regulator is adopted to prevent performance degradation in the event of a voltage drop in the battery. The receiver adopts superheterodyne structure to obtain high sensitivity, considering the link budget from the previous analysis. The receiver and transmitter were fabricated using the CMOS 0.13-μm process. The output power of the transmitter is -1.6 dB·m and its efficiency is 27.7%. The minimum sensitivity of the receiver is -80 dB·m at a bit error ratio (BER) of 3 × 10 (-6). An outer wall loop antenna is adopted for the capsule system to ensure a small size. The integrated system is evaluated using a liquid human phantom and a living pig, resulting in clean captured images.
A ferroelectric capacitor macromodel and parameterization algorithm for SPICE simulation (1994)

A compact equivalent circuit model, or macromodel, is presented which reproduces both the DC charge storage and transient switching current responses of a ferroelectric capacitor. The macromodel circuit element values are rigorously linked to physical quantities which are readily characterized with simple electrical measurements. A software package is described which both parameterizes and optimizes the model to measured data and outputs a SPICE input file. Together, the macromodel and parameterization software form a complete linkage between material characterization and circuit design which is largely transparent to the design engineer. Optimization results lend insight into the underlying theory of ferroelectric switching and the sources of nonideal charge storage. SPICE simulations demonstrate the utility of the macromodel for VLSI circuit simulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Design considerations for wastewater treatment by reverse osmosis (2005)

Reverse Osmosis is finding increasing use for the treatment of municipal and industrial wastewaters due to the growing demand for high quality water in large urban areas. The growing success of membranes in this application is related to improved process designs and improved membrane products. Key factors which have been determined to result in successful operation of large-scale plants will be discussed. Factors which play a key role in the use of RO membranes include ultra or microfiltration pretreatment, low fouling membranes, flux rate, recovery and control of fouling and scaling. In particular, high flux rates can be used when UF or MF pretreatment is used. These technologies remove most of the suspended particles that would normally cause heavy fouling of lead elements. Typically, fluxes in the range of 17-21 lmh lead to cleaning frequencies in the range of 3-4 months. By combining the use of membrane pretreatment and chloramination of the feed water through chlorine addition, two of the primary sources of RO membrane fouling can be controlled. The use of chloramine has become a proven means to control biofouling in a membrane for wastewater applications. The other significant problems for RO membranes result from organics fouling by dissolved organics and scaling due to saturation of marginally soluble salts. The former can be a significant problem for membranes, due to the strong attraction forces. To some extent, these can be mitigated by making the membrane surface more hydrophilic or changing the charge of the membrane surface. To minimize fouling, many plants are turning to low fouling membranes. Extensive studies have demonstrated that the membrane surface is hydrophilic, neutrally charged over a broad pH range, and more resistant to organic adsorption. Also, an analysis of the potential scaling issues will be reviewed. In particular, calcium phosphate has been found to be one of the key scalants that will limit RO system recovery rate. Calcium phosphate concentrations can reach high values in many wastewaters, and scaling of this compound is not often modeled in most RO projection software. Various process options will be presented to evaluate the most economic means of avoiding phosphate scaling. Finally, data from major RO wastewater treatment plants will be presented to show how the RO membranes operate under actual conditions, utilizing many of these design features. Long-term data from the 2.6 mgd Bedok demonstration Plant demonstrate that the RO membranes operate consistently on wastewater. Experiences from the 8.5 mgd (32,000 m3/day) Bedok and 10.5 mgd (40,000 m3/day) Kranji plants will also be presented. These large plants started operation in the fall of 2002 and have demonstrated an effective means to reclaim high quality water from difficult source waters, such as municipal wastewaters.
New Size-Controlled Microgels for Oil Production (2001)

Abstract New size-controlled microgels formed by crosslinking polymers under shear flow are very promizing for various applications in oil production. Indeed, when produced by using a proper polymer/crosslinker system and under the conditions needed to obtain the desired properties, these microgels should be quasi-ideal products. They are expected to control water mobility at long distances from the wells to improve sweep efficiency and reduce selectively permeability to water for water production control. For this latter application, injecting stable, preformed microgels eliminates the risks inherent to in-situ gelling which is a technique now recognized as being very difficult to control. This paper reports the results of new lab experiments conducted to complete our theoretical description of the crosslinking-under-shear process and to test the properties of these microgels in porous media. The actual properties of these microgels are compared to theoretical predictions. The results provide new theoretical insights into microgel formation and show that such microgels 1) have sizes measured directly by Photon Correlation Spectroscopy which are satisfactorily predicted by our model 2) adsorb quasi-irreversibly, forming adsorbed layers having a thickness equal to two times their viscometric radius of gyration, thus, are capable of controlling permeability more efficiently than the polymer alone 3) can be injected in porous media without any plugging tendency 4) have small internal rigidity as suggested by elastic modulus measurements and thus, they should be ideal disproportionate permeability modifiers 5) have viscosity higher than polymers in the dilute regime and extremely high in the semi-dilute regime, and 6) are stable, showing no tendency to re-form larger microgels when ageing, in presence of a suitable stabilizer.
Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers (2016)

The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor functions, is poorly understood. Here, we report that Ctip1 controls precision of neocortical development by regulating subtype identity in deep-layer projection neurons. Ctip1 is expressed by postmitotic callosal and corticothalamic projection neurons but is excluded over embryonic development from corticospinal motor neurons, which instead express its close relative, Ctip2. Loss of Ctip1 function results in a striking bias in favor of subcerebral projection neuron development in sensory cortex at the expense of corticothalamic and deep-layer callosal development, while misexpression of Ctip1 in vivo represses subcerebral gene expression and projections. As we report in a paired paper, Ctip1 also controls acquisition of sensory area identity. Therefore, Ctip1 couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections.