gebhart/patrepeval huggingface dataset:
ReCon: A tool to Recommend dynamic server Consolidation in multi-cluster data centers (2008)

Renewed focus on virtualization technologies and increased awareness about management and power costs of running under-utilized servers has spurred interest in consolidating existing applications on fewer number of servers in the data center. The ability to migrate virtual machines dynamically between physical servers in real-time has also added a dynamic aspect to consolidation. However, there is a lack of planning tools that can analyze historical data collected from an existing environment and compute the potential benefits of server consolidation especially in the dynamic setting. In this paper we describe such a consolidation recommendation tool, called ReCon. Recon takes static and dynamic costs of given servers, the costs of VM migration, the historical resource consumption data from the existing environment and provides an optimal dynamic plan of VM to physical server mapping over time. We also present the results of applying the tool on historical data obtained from a large production environment.
Role of Bruton’s tyrosine kinase in B cells and malignancies (2018)

Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) and is essential both for B cell development and function of mature B cells. Shortly after its discovery, BTK was placed in the signal transduction pathway downstream of the B cell antigen receptor (BCR). More recently, small-molecule inhibitors of this kinase have shown excellent anti-tumor activity, first in animal models and subsequently in clinical studies. In particular, the orally administered irreversible BTK inhibitor ibrutinib is associated with high response rates in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and mantle-cell lymphoma (MCL), including patients with high-risk genetic lesions. Because ibrutinib is generally well tolerated and shows durable single-agent efficacy, it was rapidly approved for first-line treatment of patients with CLL in 2016. To date, evidence is accumulating for efficacy of ibrutinib in various other B cell malignancies. BTK inhibition has molecular effects beyond its classic role in BCR signaling. These involve B cell-intrinsic signaling pathways central to cellular survival, proliferation or retention in supportive lymphoid niches. Moreover, BTK functions in several myeloid cell populations representing important components of the tumor microenvironment. As a result, there is currently a considerable interest in BTK inhibition as an anti-cancer therapy, not only in B cell malignancies but also in solid tumors. Efficacy of BTK inhibition as a single agent therapy is strong, but resistance may develop, fueling the development of combination therapies that improve clinical responses. In this review, we discuss the role of BTK in B cell differentiation and B cell malignancies and highlight the importance of BTK inhibition in cancer therapy.
Mapping of the Structural Genes of the Three Aspartokinases and of the Two Homoserine Dehydrogenases of <i>Escherichia coli</i> K-12 (1974)

Mutants requiring threonine plus methionine (or homoserine), or threonine plus methionine plus diaminopimelate (or homoserine plus diaminopimelate) have been isolated from strains possessing only one of the three isofunctional aspartokinases. They have been classified in several groups according to their enzymatic defects. Their mapping is described. Several regions of the chromosome are concerned: thrA (aspartokinase I-homoserine dehydrogenase I) is mapped in the same region as thrB and thrC (0 min). lysC (aspartokinase III) is mapped at 80 min, far from the other genes coding for diaminopimelate synthesis. metLM (aspartokinase II-homoserine dehydrogenase II) lies at 78 min closely linked to metB, metJ, and metF.
Displacement of domain walls under a nanocontact current: Mechanism for magnetoresistance asymmetric switching (2001)

We study the action of a magnetic field induced by nanocontact current pulses on the domain walls in thin magnetic films. We show that the pulses of a certain current direction shift the wall to the contact. Such an effect of attraction of the wall to the nanocontact does not depend on the initial position of the wall relative to the contact and results in an increase of nanocontact magnetoresistance. The opposite pulses repel this wall from the contact, i.e., the field action depends on the current direction. Our calculations explain experimental data relating to magnetoresistance devices.
Mutation in aspartic acid residues modifies catalytic and haemolytic activities of <i>Bacillus cereus</i> sphingomyelinase (1995)

Four aspartic acid residues (Asp126, Asp156, Asp233 and Asp295) of Bacillus cereus sphingomyelinase (SMase) in the conservative regions were changed to glycine by in vitro mutagenesis, and the mutant SMases [D126G (Asp126-->Gly etc.), D156G, D233G and D295G] were produced in Bacillus brevis 47, a protein-producing strain. The sphingomyelin (SM)-hydrolysing activity of D295G was completely abolished and those of D126G and D156G were reduced by more than 80%, whereas that of D233G was not so profoundly affected. Two mutant enzymes (D126G and D156G) were purified and characterized further. The hydrolytic activities of D126G and D156G toward four phosphocholine-containing substrates with different hydrophobicities, SM, 2-hexadecanoylamino-4-nitrophenylphosphocholine(HNP), lysophosphatidylcholine (lysoPC) and p-nitro-phenylphosphocholine (p-NPPC), were compared with those of the wild-type. The activity of D126G toward water-soluble p-NPPC was comparable with that of the wild-type. On the other hand, D156G catalysed the hydrolysis of hydrophilic substrates such as HNP and p-NPPC more efficiently (> 4-fold) than the wild-type. These results suggested that Asp126 and Asp156, located in the highly conserved region, may well be involved in a substrate recognition process rather than catalytic action. Haemolytic activities of the mutant enzymes were found to be parallel with their SM-hydrolysing activities. Two regions, including the C-terminal region containing Asp295, were found to show considerable sequence identity with the corresponding regions of bovine pancreatic DNase I. Structural predictions indicated structural similarity between SMase and DNase I. An evolutionary relationship based on the catalytic function was suggested between the structures of these two phosphodiesterases.
[Study of intrauterine cytomegaloviruses infection in pregnant women and fetuses]. (1990)

Detection of cytomegaloviruses (CMV) DNA in urine samples from pregnant women and newborns' cord blood was done by DNA-DNA hybridization. 33.3% of pregnant women showed CMV DNA sequences in the 1-3 months, 36.4% in the 4-6 months and 38.2% in the 7-9 months. The results suggested that the CMV infection rate of pregnant women increased as time went on.75.0% women with history of abnormal pregnancies showed CMV in their urine and 30.4% newborns' cord blood was positive for CMV. It is apparently that CMV infection rate in women with history of abnormal pregnancies was much higher than that of normal pregnant women and the danger of miscarriage in pregnant women with primary CMV infection at early pregnancy increased. CMV congenital infection rate was also high in newborns.
Postinduction turnoff of beta-interferon gene expression. (1990)

Viral induction of the human beta-interferon (IFN-beta) gene leads to a transient accumulation of high levels of IFN-beta mRNA. Previous studies have shown that the increase in IFN-beta mRNA levels after induction is due to an increase in the rate of IFN-beta gene transcription. In this paper, we show that the rapid postinduction decrease in the level of IFN-beta mRNA is due to a combination of transcriptional repression and rapid turnover of the mRNA. This transcriptional repression can be blocked with cycloheximide, suggesting that the synthesis of a virus-inducible repressor is necessary for the postinduction turnoff of the IFN-beta gene. Analysis of the sequence requirements for IFN-beta mRNA instability revealed two regions capable of destabilizing a heterologous mRNA. One destabilizer is an AU-rich sequence in the 3' untranslated region, and the other is located 5' to the translation stop codon.
Safety Interlocking Laser Output Prior To Optical Fiber Burnback (1986)

We have devised a system that will allow the optical sensing of high temperatures associated with the onset of optical fiber burnback, allowing immediate shuttering of the laser source. The shutter is triggered by an amplified signal obtained from the detected blackbody radiation that propagates back through the same fiber used to deliver the therapeutic laser energy. We will present some theory on the burnback phenomenon, describe the experimental setup used and discuss the results obtained.
The Serratus Anterior Muscle (1984)

The serratus anterior muscle has the potential of being used alone, with skin, or with skin and bone for transposition or for transplantation. Its use either inside or outside of the chest is essentially limited only the skill and experience of the surgeon. The serratus anterior muscle is a robust and reliable muscle unit. It is relatively easily dissected and has a dependable blood supply with a consistent axis of rotation. Experience suggests that this particular muscle is as reliable as other more frequently used muscles of the chest wall and is particularly useful for transposition to an intrathoracic position for life-threatening situations.
A 10 Gb/s hybrid-integrated receiver array module using a planar lightwave circuit (PLC) platform including a novel assembly region structure (1996)

A planar lightwave circuit (PLC) platform for optoelectronic hybrid integration shows potential for achieving 10 Gb/s operation. It uses AuSn bump-type bonding pads on a silica layer to decrease parasitic capacitance, which limited the CR time constant in the optical chip assembly region, and two-layer electrical wiring to reduce parasitic inductance, which caused resonance in the electrical circuit region. An arrayed receiver module fabricated by integrating a two-channel monolithic opto-electronic integrated circuit (OEIC) chip on the PLC platform demonstrated a 3 dB-bandwidth of 8 GHz in both channels, which is equal to the bandwidth of the OEIC chip. This shows the feasibility of using this PLC platform for multichannel 10 Gb/s operation. Furthermore, this PLC platform can combine the versatile optical circuit functions of a PLC, such as an arrayed-waveguide grating wavelength multiplexer, with the high-speed signal processing function of mature electronic IC circuits. Consequently, this platform is a key device that will lead to high-capacity optical signal processing systems using optical wavelength/frequency routing.
Chloroquine: Physiological Basis of Drug Resistance in <i>Plasmodium berghei</i> (1966)

Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.
EBIMed—text crunching to gather facts for proteins from Medline (2007)

Available at http://www.ebi.ac.uk/Rebholz-srv/ebimed
Synthesis and antiviral activity of benzyl-substituted imidazo[1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives (1995)

A variety of imidazo[1,5-a]-1,3,5-triazine derivatives carrying C-, O-, and S-benzyl and/or 4-methylbenzyl groups were synthesized and examined for their inhibitory effects on the replication of ortho- and paramyxoviruses. The key compounds 8-R-2-thioxo-2,3-dihydroimidazo [1,5-a]-1,3,5-triazin-4(1H)-ones 3a,b,d were synthesized by chlorotrimethylsilane/HMDS-effected cyclization--rearrangement of the corresponding 6-amino-5-(formylamino)-5-R-2-mercaptopyrimidin-4(5H)-ones 2a,b,d (R = benzyl, 4-methylbenzyl and 5-(benzyloxy)pentyl). Compounds 3a,b were further transformed into 4-thiones 5a,b and 4-dimethylamino derivatives 7a,b. Preparation of S-methyl, S-benzyl, and S-(4-methylbenzyl) derivatives 12-19 was carried out by the treatment of thioxo compounds 3b,d, 5b, and 8b in an alcohol/potassium carbonate system with methyl iodide or the appropriate aralkyl bromide. Simultaneous presence of the benzyl and thio structural units was found to be indispensable for any selective biological activity. Some 2-thio substituted compounds were specifically inhibitory to some viruses, e.g., 8-(4-methylbenzyl)-2-[(4-methylbenzyl) thio]imidazo[1,5-a]-1,3,5-triazin-4-one (13) and 8-[5-(benzyloxy)pentyl]-2-[(4-methylbenzyl)thio]imidazo [1,5-a]-1,3,5-triazin-4-one (15) inhibited influenza A virus at a concentration of 4.1 and 5.3 microM, and 2-(benzylthio)-6, 8-dimethylimidazo[1,5-a]-1,3,5-triazin-4-one (16) and 6, 8-dimethyl-2-[(4-methylbenzyl)thio]imidazo[1,5-a]1,3, 5-triazin-4-one (17) inhibited respiratory syncytial virus at a concentration of 21.9 and 15.7 microM, respectively, that is, at concentrations that were 20-50-fold lower than the cytotoxic concentrations. Compound 13 was inhibitory to respiratory syncytial virus at a concentration of 1.4 microM, that is, at a concentration that was 180-fold lower than the cytotoxic concentration to MDCK or Vero cells but only 7-fold lower than the cytotoxic concentration to HeLa cells. The 4-thiones 5a,b were nonselectively inhibitory to ortho-and paramyxoviruses at concentrations that coincided with their cytotoxic concentrations.
Estrogen receptor mutations in tamoxifen-resistant breast cancer. (1994)

Clinical resistance to antiestrogens like tamoxifen is a major problem in the treatment of hormone-dependent breast cancers. Since the estrogen receptor plays a central role in mediating the effects of estrogens and antiestrogens, we hypothesized that mutations in the estrogen receptor could be one mechanism by which breast tumors evolve from a hormone-dependent to a hormone-independent phenotype. The eight exons of the estrogen receptor complementary DNA from 20 tamoxifen-resistant and 20 tamoxifen-sensitive tumors were screened by Single Strand Conformation Polymorphism (SSCP), and the variant conformers were sequenced to identify the nucleotide changes. A 42-base pair replacement was found in exon 6 of a tamoxifen-resistant tumor. A single base pair deletion in exon 6 of a tamoxifen-resistant metastatic tumor but not in the primary tumor was detected in another case. If translated, both these mutations could generate truncated receptors with an intact DNA-binding domain and a defective hormone-binding domain that could constitutively activate transcription of previously estrogen-responsive genes. The remaining 18 of 20 tamoxifen-resistant tumors did not contain mutations in any of the 8 exons of the estrogen receptor complementary DNA. These results suggest that mutations in the estrogen receptor occur at a low frequency and do not account for most estrogen-independent, tamoxifen-resistant breast tumors.
Secure communication among robots and humans with a human voice (2012)

As firefighting situations are urgent, the demand of firefighting robots communicating with a human in a natural language is increasing as it is efficient in that there is no need an commander to get trained for operating a controller. However, when communicating with a human in a natural language, there is an issue regarding security; firefighting robots are supposed to operate according to commands by an authorized commander, it is difficult that firefighting robots verify authentication with a human voice. However, it is still important to keep the communication between a human (a commander, not an adversary) and a firefighting robot secure due to any potential situation of a person setting fire on purpose and wanting to hinder firefighting tasks. Thus, I am currently researching to realize a secure and accurate communication in a human language.
Drug repositioning by structure-based virtual screening (2013)

Approved drugs have favourable or validated pharmacokinetic properties and toxicological profiles, and the repositioning of existing drugs for new indications can potentially avoid expensive costs associated with early-stage testing of the hit compounds. In recent years, technological advances in virtual screening methodologies have allowed medicinal chemists to rapidly screen drug libraries for therapeutic activity against new biomolecular targets in a cost-effective manner. This review article outlines the basic principles and recent advances in structure-based virtual screening and highlights the powerful synergy of in silico techniques in drug repositioning as demonstrated in several recent reports.
Preparation of HMX with Nanometer Particle Size and Narrow Particle Distribution (2004)

HMX with nanometer particle size and narrow particle distribution was successfully prepared by impinging method. The effects of different dispersants on particle size and particle size distribution were studied in some detail. It is concluded that dispersant 1 and dispersant 2 can improve considerably the particle distribution of HMX. In the presence of a suitable amount of dispersant 1,the obtained HMX has a effective average particle diameter of 70.1 nm and 68.9 nm,a particle distribution range of 0.9 nm and 1.4 nm respectively.
Numerical, analytical, experimental study of fluid dynamic forces in seals (2004)

NASA/Lewis Research Center is sponsoring a program for providing computer codes for analyzing and designing turbomachinery seals for future aerospace and engine systems. The program is made up of three principal components: (1) the development of advanced three dimensional (3-D) computational fluid dynamics codes, (2) the production of simpler two dimensional (2-D) industrial codes, and (3) the development of a knowledge based system (KBS) that contains an expert system to assist in seal selection and design. The first task has been to concentrate on cylindrical geometries with straight, tapered, and stepped bores. Improvements have been made by adoption of a colocated grid formulation, incorporation of higher order, time accurate schemes for transient analysis and high order discretization schemes for spatial derivatives. This report describes the mathematical formulations and presents a variety of 2-D results, including labyrinth and brush seal flows. Extensions of 3-D are presently in progress.
Immune Development and Intestinal Microbiota in Celiac Disease (2012)

Celiac disease (CD) is an immune-mediated enteropathy, triggered by dietary wheat gluten and similar proteins of barley and rye in genetically susceptible individuals. The etiology of this disorder is complex, involving both environmental and genetic factors. The major genetic risk factor for CD is represented by HLA-DQ genes, which account for approximately 40% of the genetic risk; however, only a small percentage of carriers develop the disease. Gluten is the main environmental factor responsible for the signs and symptoms of the disease, but exposure to gluten does not fully explain the manifestation of CD. Epidemiological and clinical data suggest that environmental factors other than gluten might play a role in disease development, including early feeding practices (e.g., breast milk versus formula and duration of breastfeeding), infections, and alterations in the intestinal microbiota composition. Herein, we review what is known about the influence of dietary factors, exposure to infectious agents, and intestinal microbiota composition, particularly in early life, on the risk of developing CD, as well as the possible dietary strategies to induce or increase gluten tolerance.
SLAM-based cooperative calibration for optical sensors array with GPS/IMU aided (2016)

Loading wide baseline multi-arrays optical sensor system enables a UAV to obtain large field of view and multi-view information, and maximize its detection performance. An accurate calibration is a necessary prerequisite. Since the key problem on the calibration of multi-array optical system is how to find the accurate extrinsic parameters of single array, we propose a cooperative calibration with GPS/IMU aided for the single array optical system to improve the accuracy of calibration. Our method does not require an initial guess of any extrinsic parameter. Through extensive field tests on ground prototype experimental system, we demonstrate that our algorithm has more accuracy compared to multi-camera calibration without GPS/IMU aided as well as robustness for calibration of single array optical system.
Martensitic transitions and the nature of ferromagnetism in the austenitic and martensitic states of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi mathvariant="normal">Ni</mml:mi><mml:mo>−</mml:mo><mml:mi mathvariant="normal">Mn</mml:mi><mml:mo>−</mml:mo><mml:mi mathvariant="normal">Sn</mml:mi></mml:mrow></mml:math>alloys (2005)

Structural and magnetic transformations in the Heusler-based system ${\mathrm{Ni}}_{0.50}{\mathrm{Mn}}_{0.50\ensuremath{-}x}{\mathrm{Sn}}_{x}$ are studied by x-ray diffraction, optical microscopy, differential scanning calorimetry, and magnetization. The structural transformations are of austenitic-martensitic character. The austenite state has an $L{2}_{1}$ structure, whereas the structures of the martensite can be $10M$, $14M$, or $L{1}_{0}$ depending on the Sn composition. For samples that undergo martensitic transformations below and around room temperature, it is observed that the magnetic exchange in both parent and product phases is ferromagnetic, but the ferromagnetic exchange, characteristic of each phase, is found to be of different strength. This gives rise to different Curie temperatures for the austenitic and martensitic states.
Frequency of Dry Eye Diagnostic Test Procedures Used in Various Modes of Ophthalmic Practice (2000)

Symptom assessment plays a large role in the diagnosis of dry eye. The current clinical standard of care for dry eye diagnosis includes the performance of at least one test procedure in addition to a symptom assessment.
Detection of antibodies against human papillomavirus (HPV) type 16 virions by enzyme-linked immunosorbent assay using recombinant HPV 16 L1 capsids produced by recombinant baculovirus (1995)

The L1 major capsid protein of human papillomavirus type 16 (HPV-16) was expressed in Sf-21 insect cells with a recombinant baculovirus. Virus-like particles obtained were purified and used to develop an enzyme-linked immunosorbent assay for detection of anti-HPV-16 antibodies in sera from 76 women with evidence of genital HPV infection and 79 controls. HPV-16-infected individuals developed antibodies directed at HPV-16 virions since reactivity against recombinant HPV-16L1 capsids was observed in 50% of them compared with only 6% in the general adult population. However, some cross-reactivities with sera from women infected with others HPV types were observed.