gebhart/patrepeval huggingface dataset:
Practical Identifiability of the Manipulator Link Stiffness Parameters (2013)

The paper addresses a problem of the manipulator stiffness modeling, which is extremely important for the precise manufacturing of contemporary aeronautic materials where the machining force causes significant compliance errors in the robot end-effector position. The main contributions are in the area of the elastostatic parameters identification. Particular attention is paid to the practical identifiability of the model parameters, which completely differs from the theoretical one that relies on the rank of the observation matrix only, without taking into account essential differences in the model parameter magnitudes and the measurement noise impact. This problem is relatively new in robotics and essentially differs from that arising in geometrical calibration. To solve the problem, several physical and statistical model reduction methods are proposed. They are based on the stiffness matrix sparseness taking into account the physical properties of the manipulator elements and also on the heuristic selection of the practically non-identifiable parameters that employs numerical analyses of the parameter estimates. The advantages of the developed approach are illustrated by an application example that deals with the stiffness modeling of an industrial robot used in aerospace industry.
New alarm system permits early detection of small leaks (1983)

The Leakage Alarm System for Pipe Lines (L.A.S.P.) represents a method for early detection of small leaks along a pipe line several miles long. The location and size of a leak can be easily determined. The sensor tube is rugged, is long lived, and is easy to install. High detection sensitivity with automatic self-checking and a large signalto-background level ratio (normally 1,000:1) provides a highly reliable system of leak surveillance for pipe lines.
L-carnitine Supplemented Extender Improves Cryopreserved-thawed Cat Epididymal Sperm Motility (2014)

Cryopreservation of epididymal sperm is an effective technique to preserve genetic materials of domestic cats and wild felids when they unexpectedly die. However, this technique inevitably causes detrimental changes of cryopreserved-thawed spermatozoa, for example, by physical damage and excessive oxidative stress. L-carnitine is an antioxidant that has been used to improve sperm motility in humans and domestic animals. This study aimed to investigate the effects of L-carnitine on cat epididymal sperm quality following cryopreservation and thawing. After routine castration, cauda epididymides were collected from 60 cat testes. The epididymal spermatozoa from 3 cauda epididymides were pooled as 1 replicate. Spermatozoa samples (16 replicates) were examined for spermatozoa quality and then randomly divided into 4 groups: 0 mM L-carnitine (control), 12.5 mM, 25 mM and 50 mM L-carnitine. The sperm aliquots were then equilibrated and conventionally frozen. After thawing, sperm motility, plasma membrane integrity, DNA integrity and acrosome integrity were evaluated. The 25 mM L-carnitine significantly improved sperm motility compared with a control group (p<0.05), although this was not significantly different among other concentrations. In conclusion, supplementation of 25 mM L-carnitine in freezing extender improves cauda epididymal spermatozoa motility. The effects of L-carnitine on the levels of oxidative stress during freezing and thawing remains to be examined.
REVIEWS (1963)

REVIEWS Get access J. A. VAN DORSTEN. Thomas Bosson, 1555–1613: English Printer at Leiden. Leiden University Press, for the Sir Thomas Browne Institute, 1961. pp. x + 126. 21s. J. A. VAN DORSTENPoets, Patrons and Professors: Sir Philip Sidney, Daniel Rogers and the Leiden Humanists. Leiden University Press, for the Sir Thomas Browne Institute, 1962. pp. xi + 227. 38s. A. G. H. BACHRACHSir Constantine Huygens and Britain, 1596–1687: A Pattern of Cultural Exchange, Vol. i, 1596–1619, Leiden University Press, for the Sir Thomas Browne Institute, 1962. pp. xii + 238. 38s. Christopher Hill Christopher Hill Balliol CollegeOxford Search for other works by this author on: Oxford Academic Google Scholar Past & Present, Volume 25, Issue 1, July 1963, Pages 90–92, https://doi.org/10.1093/past/25.1.90 Published: 01 July 1963
Highly Permeable Zeolite Imidazolate Framework-8 Membranes for CO<sub>2</sub>/CH<sub>4</sub> Separation (2009)

ZIF-8 membranes, a type of zeolite imidazolate framework, were synthesized by secondary seeded growth on tubular alpha-Al(2)O(3) porous supports. The presence of small, highly crystalline, microporous crystals with narrow particle size distribution led to continuous thin membranes. The synthesized novel ZIF-8 membranes displayed unprecedented high CO(2) permeances and relatively high separation indexes for equimolar mixtures of CO(2) and CH(4).
Antimicrobial Pharmacodynamics in Theory and Clinical Practice (2007)

Introduction. Pharmacodynamics of Antimicrobials: General Concepts and Applications Impact of Pharmacodynamics on Breakpoint Selection for Susceptibility Testing. Non-Clinical Models of Infection. In Vitro Antibiotic Pharmacokinetic Models. Animal Models of Infection for the Study of Antibiotic Pharmacodynamics. The Predictive Value of Laboratory Tests for Efficacy of Antibiotic Combination Therapy. Antibacterial Agents. Beta-Lactam Antibiotics. Aminoglycoside Antibiotics. Quinolones. Glycopeptides. Macrolide, Azalide and Ketolides. Metronidazole, and Clindamycin. Streptogramins, Oxazolididones. Tetracyclines. Antiviral Agents. Nucleoside Reverse Transcriptase Inhibitors. Protease Inhibitors. Hepatitis B and C. Antifungal Agents. Amphotericin. Azoles. Gulcan Synthase Inhibitors. Antimalarial Agents. Anti-Malarials. Pharmacodynamics in Drug Development. Human Pharmacodynamics of Anti-Infectives: Determination from Clinical Trial Data. Pharmacodynamics in Global Bridging Studies. Toxicodynamics. Pharmacodynamics and Resistance. Antibacterial Resistance. Application of PK-PD to Clinical and Formulary Decisions. Basic Pharmacoeconomics. Utilizing Pharmacodynamics and Pharmacoeconomics in Clinical and Formulary Decision Making.
Synthesis, biological evaluation and docking of novel bisamidinohydrazones as NON-peptide inhibitors of furin (2015)

A series of novel non-peptidicfurin inhibitors with values of inhibitory constants (Ki) in the range of 0.74-1.54 μM was obtained by interactions of aminoguanidine hydrocarbonate with three diaryldicarbalde- hydes. Correspondingly p-hydroquinone, piperazine and adipic acid were used as linkers between their ben- zene moieties. Docking studies of these new inhibitors into recently published 3D-structure of human furin (PDB code 4OMC) showed that they were able to interact with subsites S1 and S4 of the enzyme. The overall arrangement of bisamidinohydrazones into furin active site was similar to the position of the ligand co- crystallized with a protease. Observations obtained with molecular modeling allowed further guidance into chemical modifications of the synthesized inhibitors which improve their inhibitory activity.
Ann Connors (2019)

Ann Connors writes a letter to her younger self as part of Dustin Harvey’s Best Wishes project. In the letter, the producer and advocate reflects on the experiences of her life and career and gives the advice she wishes she had had starting out.
Modeling languages versus matrix generators for linear programming (1983)

Linear optimization problems (hnear programs) are expressed in one kind of form for human modelers, but m a quite different form for computer algorithms. Translation from the modeler's form to the algorithm's form is thus an unavoidable task in hnear programming. Traditionally, this task of translation has been divided between human and computer, through the writing of computer programs known as matrix generators
Motion Compensated Tomography Reconstruction of Coronary Arteries in Rotational Angiography (2008)

This paper deals with the 3-D reconstruction of the coronary tree from a rotational X-ray projection sequence. It describes the following three stages: the reconstruction of the 3-D coronary tree at different phases of the cardiac cycle, the motion estimation, and the motion-compensated tomographic reconstruction of the 3-D coronary tree at one given phase using all the available projections. Our method is tested on a series of simulated images computed from the projection of a segmented dynamic volume sequence acquired in multislice computed tomography imaging. Performances are comparable to those obtained by reconstruction of a statical coronary tree using an algebraic reconstruction technique algorithm.
Tactile and Multisensory Spatial Warning Signals for Drivers (2008)

The last few years have seen many exciting developments in the area of tactile and multisensory interface design. One of the most rapidly-moving practical application areas for these findings is in the development of warning signals and information displays for drivers. For instance, tactile displays can be used to awaken sleepy drivers, to capture the attention of distracted drivers, and even to present more complex information to drivers who may be visually-overloaded. This review highlights the most important potential costs and benefits associated with the use of tactile and multisensory information displays in a vehicular setting. Multisensory displays that are based on the latest cognitive neuroscience research findings can capture driver attention significantly more effective than their unimodal (i.e., tactile) counterparts. Multisensory displays can also be used to transmit information more efficiently, as well as to reduce driver workload. Finally, we highlight the key research questions currently awaiting further research, including questions such as: Are tactile warning signals really intuitive? Are there certain regions of the body (or in the space surrounding the body) where tactile/multisensory warning signals are particularly effective? To what extent is the spatial coincidence and temporal synchrony of the individual sensory signals critical to determining the effectiveness of multisensory displays? And, finally, how does the issue of compliance vs. reliance (or the 'cry wolf' phenomenon associated with the presentation of signals that are perceived as false alarms) influence the effectiveness of tactile and/or multisensory warning signals?
LightNN: Filling the Gap between Conventional Deep Neural Networks and Binarized Networks (2017)

Application-specific integrated circuit (ASIC) implementations for Deep Neural Networks (DNNs) have been adopted in many systems because of their higher classification speed. However, although they may be characterized by better accuracy, larger DNNs require significant energy and area, thereby limiting their wide adoption. The energy consumption of DNNs is driven by both memory accesses and computation. Binarized Neural Networks (BNNs), as a trade-off between accuracy and energy consumption, can achieve great energy reduction, and have good accuracy for large DNNs due to its regularization effect. However, BNNs show poor accuracy when a smaller DNN configuration is adopted. In this paper, we propose a new DNN model, LightNN, which replaces the multiplications to one shift or a constrained number of shifts and adds. For a fixed DNN configuration, LightNNs have better accuracy at a slight energy increase than BNNs, yet are more energy efficient with only slightly less accuracy than conventional DNNs. Therefore, LightNNs provide more options for hardware designers to make trade-offs between accuracy and energy. Moreover, for large DNN configurations, LightNNs have a regularization effect, making them better in accuracy than conventional DNNs. These conclusions are verified by experiment using the MNIST and CIFAR-10 datasets for different DNN configurations.
Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. (2001)

Factors that determine the biological and clinical behavior of prostate cancer are largely unknown. Prostate tumor progression is characterized by changes in cellular architecture, glandular organization, and genomic composition. These features are reflected in the Gleason grade of the tumor and in the development of aneuploidy. Cellular architecture and genomic stability are controlled in part by centrosomes, organelles that organize microtubule arrays including mitotic spindles. Here we demonstrate that centrosomes are structurally and numerically abnormal in the majority of prostate carcinomas. Centrosome abnormalities increase with increasing Gleason grade and with increasing levels of genomic instability. Selective induction of centrosome abnormalities by elevating levels of the centrosome protein pericentrin in prostate epithelial cell lines reproduces many of the phenotypic characteristics of high-grade prostate carcinoma. Cells that transiently or permanently express pericentrin exhibit severe centrosome and spindle defects, cellular disorganization, genomic instability, and enhanced growth in soft agar. On the basis of these observations, we propose a model in which centrosome dysfunction contributes to the progressive loss of cellular and glandular architecture and increasing genomic instability that accompany prostate cancer progression, dissemination, and lethality.
Thermoelastic stress analysis (1991)

An introduction to thermoelastic stress analysis, N.Harwood et al thermal analysis of deformation mechanisms using a contacting technique, M.G.Beghi TSA signal processing and data collection, B.R.Boyce signal attenuation duw to internal and external factors, J.McKelvie and A.K.MacKenzie application of SPATE in fracture mechanics, P.Stanley variable-amplitude loading, N.Harwood and W.M.Cummings the thermoelastic effect - a higher order consideration, A.K.Wong thermoelastic analysis of anisotropic materials, R.T.Potter post-processing of SPATE data, J.T.Boyle.
Laparoscopic Bladder‐Neck Suspension for Urinary Stress Incontinence in Women: Our First Twenty Patients (1996)

Long-term follow-up is necessary to determine the efficacy of this laparoscopic technique. The success rate for any incontinence procedure is usually inversely proportional to the duration of follow-up.
The photoluminescence of SiCN thin films prepared by C+ implantation into alpha-SiNx:H (2010)

SiCN thin films were prepared by high-dosage (2 x 10(17) cm(-2)) C+ ion implantation into alpha-SiNx:H films. The prepared films were then processed by thermal annealing for 2 h at 800 degrees C, 1000 degrees C and 1200 degrees C respectively. The composi
Prolactin Release During Nursing and Breast Stimulation in Postpartum and Nonpostpartum Subjects<sup>1</sup> (1974)

The effect of suckling and breast stimulation on plasma prolactin measured by homologous radioimmunoassay has been studied in nursing women, in normal, nonlactating women and men, in chlorpromazine treated women, in pregnant women, and in women with galactorrhea. Nursing women had increased plasma prolactin before nursing during the first 6 weeks postpartum; mean prolactin rose rapidly throughout the period of suckling and reached a peak 8.5 times the baseline value just after the termination of nursing. Women studied between 7 and 28 weeks postpartum had normal prolactin levels before nursing; with suckling they had smaller but significant elevations, averaging 6.0 times the baseline value at the end of nursing. When nursing women were allowed to play with but not nurse their infants, prolactin did not rise in spite of the occurrence of milk let-down. Substitution of a breast pump for the infant at a regular period of nursing caused prolactin elevations similar in timing and in magnitude to those occurring during suckling. Stimulation of the breast with a breast pump for 30 min produced significant prolactin increases in 7 out of 18 normal women and failed to increase prolactin in normal men. Self-administered stimulation of the nipple and areola also produced prolactin increases in a minority of normal women. Stimulation of nursing in normal women by frequent daily periods of breast stimulation for 2 to 14 days produced no increase in basal prolactin or in prolactin response to breast manipulation in 2 subjects. Chronic chlorpromazine treatment raised basal prolactin but did not enhance the sensitivity to breast stimulation in 4 subjects. Breast pump stimulation caused prolactin rises in all of 3 pregnant women and induced lactation in 1 woman in the seventh month of pregnancy. Of 9 women with galactorrhea, only 1 had increased prolactin after breast pump or manual stimulation. We conclude that sensory stimuli arising from mechanical stimulation of the breast can release prolactin in a minority of normal women; after pregnancy and parturition the effect is seen in all women, and persists with diminishing force as nursing is continued. While estrogenic stimulation during pregnancy may sensitize the breast and pituitary to facilitate prolactin release around the time of delivery, estrogen differences cannot explain the differences in sensitivity seen among normal women, or the persistence of sensitivity in nursing mothers many weeks postpartum.
Synthesis and fluorescence properties of substituted 7‐aminocoumarin‐3‐carboxylate derivatives (2000)

Abstract 4‐Trifluoromethyl‐ or 6‐bromo‐substituted 7‐diethylaminocoumarin‐3‐carboxamide derivatives 2 and 3, each containing a maleimide have been synthesized as potential fluorescent labeling reagents for thiol groups in proteins and their fluorescence properties have been determined. The 4‐trifluoromethyl substituted compound 2 has a significantly greater Stokes shift than the comparable compound lacking this group, but both the new coumarins have low fluorescence quantum yields (ϕ f ). When a 4‐trifluoromethyl substituent is present, the 3‐carboxamide is unusually labile to hydrolysis. Bromination of ethyl 7‐diethylaminocoumarin‐3‐carboxylate 17 gave the 6‐ and 8‐bromo derivatives 18 and 19 respectively, and also the 8‐bromo‐7‐monoethylamino compound 20. ϕ f for the latter compound is 100‐fold greater than for its diethylamino analogue 19. Fluorescence lifetime measurements support an interpretation based on the twisted intramolecular charge transfer (TICT) model to explain these large differences in ϕ f .
Inositol phosphates in the duckweed <i>Spirodela polyrhiza</i> L (1996)

We have undertaken an analysis of the inositol phosphates of Spirodela polyrhiza at a developmental stage when massive accumulation of InsP6 indicates that a large net synthesis is occurring. We have identified Ins3P, Ins(1,4)P2, Ins(3,4)P2 and possibly Ins(4,6)P2, Ins(3,4,6)P3, Ins(3,4,5,6)P4, Ins (1,3,4,5,6)P5, D- and/or L-Ins(1,2,4,5,6)P5 and InsP6 and revealed the likely presence of a second InsP3 with chromatographic properties similar to Ins(1,4,5)P3. The higher inositol phosphates identified show no obvious direct link to pathways of metabolism of second messengers purported to operate in higher plants, nor do they resemble the immediate products of plant phytase action on InsP6.
Titelei/Inhaltsverzeichnis (2011)

3. durchgesehene Auflage mit <A HREF=' HTTP://www.wallstein-verlag.de/Berg Register.pdf' > Personenregister </A>
A multistatic tomographic approach to microwave imaging of dielectric targets (2011)

In the last years, the development of microwave imaging systems, aimed at reconstructing images of the dielectric properties of unknown targets from measures of the scattered field, has been a continuously pursued target. There are mainly two topics that must be faced. First of all, it is necessary to create fast and efficient measurement setups for obtaining the samples of the scattered electric field. Secondly, it is necessary to develop numerical methods able to extract from such measured values the needed information. In this paper, a multistatic measurement setup and an efficient reconstruction procedure are presented. Experimental results are provided in order to demonstrate the effectiveness of the proposed system.
Efficient and Scalable Synthesis of Ethyl 2,6-Dichloro-5-Fluoronicotinoyl Acetate Using the Blaise Reaction as a Key Step<sup>1</sup> (2005)

An efficient synthesis of 2,6-dichloro-5-fluoronicotinoyl acetate (1) has been accomplished in a single step using the Blaise reaction of ethyl bromoacetate with 3-cyano-2,6-dichloro-5-fluoropyridine (4). Use of methanesulfonic acid as an in situ activator of zinc removed the induction period of the Blaise reaction to render it safe and viable for a large-scale operation.
Encyclopedic Handbook of Emulsion Technology (2001)

Characterization of water/oil interfaces a few examples of the importance of phase diagrams for the properties and behaviour of emulsions structure and stability of emulsions coupling of coalescence and flocculation in dilute water/oil emulsions macroemulsions from the perspective of microemulsions dielectric spectroscopy on emulsions and related colloidal systems - a review electroacoustic characterization of emulsions acoustic and electroacoustic spectroscopy for characterizing emulsions and microemulsions food emulsions ultrasonic characterization of food emulsions rheology of concentrated emulsions emulsions -the NMR perspective surface forces and emulsions stability microcalorimetry video enhanced microscopy investigation of droplets and size distributions conductivity measurements multiple emulsions environmental emulsions towards the atomic-level simulations of water-in-crude oil membranes asphaltene based crude oil emulsions heavy crude oil emulsions water-in-crude oil emulsions in recovery of hydrocarbons for oil sand interfacial rheology of crude oil emulsions film properties of ashaltenes and resins chemical demulsification of stable crude oil and bitumen emulsions in petroleum recovery - a review demulsifiers in oil industry dynamic processes in surfactant stabilized emulsions three-phase wellstream gravity separation compact electrostatic coalescer technology formation of gas hydrates in stationary and flowing water/oil emulsions.
Classifying gene expression data of cancer using classifier ensemble with mutually exclusive features (2002)

The explosion of DNA and protein sequence data in public and private databases has been encouraging interdisciplinary research on biology and information technology. Gene expression profiles are just sequences of numbers, and the necessity of tools analyzing them to get useful information has risen significantly. In order to predict the cancer class of patients from the gene expression profile, this paper presents a classification framework that combines a pair of classifiers trained with mutually exclusive features. The idea behind feature selection with nonoverlapping correlation is to encourage classifier ensemble, which consists of multiple classifiers, to learn different aspects of training data, so that classifiers can search in a wide solution space. Experimental results show that the classifier ensemble produces higher recognition accuracy than conventional classifiers.
The roles of glucose metabolic reprogramming in chemo- and radio-resistance (2019)

Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. The procedure is involved in the alteration of many activities, such as the aberrant DNA repairing, enhanced autophagy, oxygen-deficient environment, and increasing exosomes secretions, etc. Targeting altered metabolic pathways related with the glucose metabolism has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.