gebhart/patrepeval huggingface dataset:
Antagonism of maximal metrazol seizures in rats and its relevance to an experimental classification of antiepileptic drugs. (1976)

The antagonism of various components of maximal Metrazol-seizures (MMS) (i.e. tonic hindpaw extension, tonic backward extension of the forepaws, generalized clonic seizures and tremors), ataxia and loss of righting reflex-activity have been studied in a standardized procedure comparing 41 antiepileptics and related compounds. Appropriate analyses (Cluster Analysis and Principal Component Analysis) resulted in the distinction of seven clusters which could be considered along two continua. A first continuum is characterized by a progressive strengthening of loss of righting reflex-inducing properties, a decreasing dissociation of ataxia and loss of righting reflex and the disappearance of a selective anticonvulsant effect. The second continuum is characterized by an increasing relative potency of ataxia-inducing properties, an increasing dissociation of ataxia and loss of righting reflex and a decreasing antagonism of tremors. Three main types of anticonvulsants could be defined: drugs with a complete anti-MMS effect antagonizing both clonic and tonic seizures; drugs selectively abolishing tonic seizures, i.e., tonic extension of hind- and forepaws; and drugs exclusively blocking tonic hind-paw extension. The neurological and clinical significance of these different types of anticonvulsant activity has been discussed. Finally, the described modification of the maximal Metrazol-seizures test is proposed for routine screening purposes.
[Glucagon-like peptide-1--a new hormone and a new drug]. (1998)

Glucagon-like peptide-1 (GLP-1 is an insulinotropic hormone, which is secreted from endocrine cells of the intestinal mucosa in relation to meal ingestion. It plays an important role as an incretin hormone; thus, mice with a null-muation in the gene encoding the GLP-1 receptor are glucose intolerant. In addition, GLP-1 inhibits gastrointestinal secretion and motility and is thought to act as one of the hormones of the "ileal brake". The insulinotropic effect of GLP-1 is preserved in patients with non insulin-dependent diabetes mellitus (NIDDM) and, because GLP-1 also inhibits glucagon secretion, it effectively lowers blood glucose in such, and given as an intravenous infusion it may completely normalise blood glucose. Furthermore, because its actions on insulin and glucagon secretion are dependent on the blood glucose levels it will not cause hypoglycemia. Efforts are therefore currently being made to employ GLP-1 or analogues thereof in clinical diabetes treatment, not least because recent investigations have shown that GLP-1, perhaps due to its gastrointestinal actions, is capable of reducing food intake in humans.
Best practices for the use of intracerebroventricular drug delivery devices (2018)

For decades, intracerebroventricular (ICV), or intraventricular, devices have been used in the treatment of a broad range of pediatric and adult central nervous system (CNS) disorders. Due to the limited permeability of the blood brain barrier, diseases with CNS involvement may require direct administration of drugs into the brain to achieve full therapeutic effect. A recent comprehensive literature review on the clinical use and complications of ICV drug delivery revealed that device-associated complication rates are variable, and may be as high as 33% for non-infectious complications and 27% for infectious complications. The variability in reported safety outcomes may be driven by a lack of consensus on best practices of device use. Numerous studies have demonstrated that employing strict aseptic techniques and following stringent protocols can dramatically reduce complications. Key practices to be considered in facilitating the safe, long-term use of these devices are presented.
Multi-intruder, multi-sensor tracking system (2015)

This article consists of a collection of slides from the author's conference presentation.
A Common Approach to Accessing Real-Time Operations Data: Introducing Service- Oriented Architecture to E&P (2005)

Abstract Due to the high degree of diversity in which real-time operations and production data is stored and distributed within BP-indeed, within almost any large oil company today-E&P professionals who carry out similar activities in different assets or business units must access data in distinctly different ways. Therefore, any attempt to implement a "standard" application requires IT personnel to have intimate knowledge of the underlying data sources within every asset. Scale up and rapid adoption across multiple assets of either new or proven digital technologies is extremely difficult as well, due to disparate IT architectures. The challenges and complexities caused by lack of standardization have fostered rampant development of local, costly, and time-consuming "point solutions"-typically "hard-wired" point-to-point connections between each data source and each application, whether proprietary or commercial. This familiar approach to integration seriously compromises the organization's technical flexibility in the face of ongoing business changes. As a result, business units within BP have increasingly requested standardized digital solutions that would enable seamless data flow among different classes of E&P applications and business processes. The Real-Time Architecture Project (RTAP), initiated in 2003, now provides a common approach for all assets to access real-time production operations data. It is built around a simple connection technology capable of integrating a wide range of tools such as production reporting, real-time visualization and active alerting with new or existing data sources of many kinds. RTAP utilizes "Web Service" technologies, which create highly flexible interfaces based on established and emerging Internet standards. BP's ultimate goal is to implement a common, standards-based architecture for data access and integration, replacing the large number of custom, proprietary interfaces currently in use. Since launching RTAP two years ago, significant progress has been made toward this goal, with the intent of expanding the current implementation to a next-generation "Service Oriented Architecture" (SOA) in the near future. This paper provides a review of the RTAP project's origins and development efforts, BP's rationale for this approach, a high-level, non-technical description of the solution, an overview of associated business benefits, and a case study validating the approach. The potential for Service Oriented Architectures in E&P-which represent a paradigm shift in how IT is developed and deployed-and the need for industry standards in this exciting new area, will also be discussed.
Cellulose acetate trimellitate ethylcellulose blends for non-steroidal anti-inflammatory drug (NSAID) microspheres (1996)

Ketoprofen (Ket), a non-steroidal anti-inflammatory drug, has been incorporated into polymeric micromatrices (microspheres) prepared by a spray drying process and made of cellulose acetate trimellitate (CAT)/ethylcellulose (EC) blends. Drug loaded microspheres were obtained by spray-drying organic solutions of the two polymers and the drug. Characterization of the microparticles (morphology, particle size distribution, drug content, yield of production, surface properties, solvent residues) was carried out and in-vitro release behaviour measured. The release rate of the drug diminished as the proportion of EC was raised.
Strands and hair (2007)

The last six years has seen a renaissance in hair modeling, rendering and animation. This course covers the gamut of hair simulation problems and present working solutions, from recent and novel research ideas to time tested industrial practices that resulted in spectacular imagery.
Effect of Radial Flow Nonuniformity on the Alkylation Reaction in a Liquid−Solid Circulating Fluidized Bed (LSCFB) Reactor (1997)

A two-channel reaction model is proposed for reactions in the liquid−solid circulating fluidized bed (LSCFB). With the two-channel flow model, the kinetics of benzene alkylation with dodecene over zeolite HY catalyst, and the deactivation kinetics of the catalyst, the effects of the various operating parameters on the radial distributions of the reactant concentration and the catalyst activity and on the reaction conversion in the liquid−solid riser reactor are investigated. The effect of temperature is also studied. The two-channel model is shown to provide a practical way to predict the effects of the various operating conditions on the performance of the LSCFB reactor and to be helpful for the design of the LSCFB reactors.
Genetic fusion of single‐chain variable fragments to partial spider silk improves target detection in micro‐ and nanoarrays (2015)

Immobilizing biomolecules with retained functionality and stability on solid supports is crucial for generation of sensitive immunoassays. However, upon use of conventional immobilization strategies, a major portion of the biomolecules (e.g. antibodies) frequently tends to lose their bioactivity. In this study, we describe a procedure to immobilize human single-chain variable fragment (scFv) via genetic fusion to partial spider silk, which have a high tendency to adhere to solid supports. Two scFvs, directed towards serum proteins, were genetically fused to partial spider silk proteins and expressed as silk fusion proteins in E. coli. Antigen binding ability of scFvs attached to a partial silk protein denoted RC was investigated using microarray analysis, whereas scFvs fused to the NC silk variant were examined using nanoarrays. Results from micro- and nanoarrays confirmed the functionality of scFvs attached to both RC and NC silk, and also for binding of targets in crude serum. Furthermore, the same amount of added scFv gives higher signal intensity when immobilized via partial spider silk compared to when immobilized alone. Together, the results suggest that usage of scFv-silk fusion proteins in immunoassays could improve target detection, in the long run enabling novel biomarkers to be detected in crude serum proteomes.
Bubble Column Chromatography: Measurement of Multicomponent Vapor-Liquid Equilibria (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleBubble Column Chromatography: Measurement of Multicomponent Vapor-Liquid EquilibriaCharles J. Perilloux and Harry A. DeansCite this: Ind. Eng. Chem. Fundamen. 1972, 11, 1, 138–144Publication Date (Print):February 1, 1972Publication History Published online1 May 2002Published inissue 1 February 1972https://pubs.acs.org/doi/10.1021/i160041a021https://doi.org/10.1021/i160041a021research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Kinematic simulative analysis of virtual potential field method for AUV trajectory planning (2007)

This paper deals with an analysis of applicability, capabilities, benefits and pitfalls of using a virtual potential field approach to autonomously planning trajectories in non-communicating autonomous underwater vehicles (AUV-s). Virtual potentials represent an approach to this problem with cross-layer design features. Examples of different layers of control that can be achieved with the same fundamental approach are: obstacle-avoidance, energy-optimal trajectories, forming up with other moving agents, controlled formation fragmentation into well-posed sub-formation etc. This paper shows, on the basis of extensive simulated experiments, that such a trajectory planner based on virtual potentials, guarantees good extendibility, scalability and performance in a hard-real-time hardware-in-the-loop system.
High-resolution electron microscopy studies of a microporous carbon produced by arc-evaporation (1994)

The soot produced as a byproduct of fullerene synthesis by arc-evaporation consists of a microporous carbon with a surface area, after activation with carbon dioxide, of ca. 700 m2 g–1. Here, we investigate the structure of this material, and its appearance after electron irradiation and high-temperature heat treatment, using high-resolution electron microscopy. We show that the heat treatment transforms the new carbon into a structure containing large, tube-like pores, rather than into polycrystalline graphite. This suggests that the arc-evaporated carbon may have a novel, fullerene-related microstructure, and that it may be the precursor for nanotube formation.
Zinc Oxo Clusters Improve the Optoelectronic Properties on Indium Phosphide Quantum Dots (2020)

This study explored the effect of zinc precursors on the optical properties of InP quantum dots (QDs) by controlling the reactivity of zinc carboxylates via a simple thermal treatment. The formation of zinc oxo clusters, Zn4O(oleate)6 and Zn7O2(oleate)10, during the thermal decomposition of zinc oleate was confirmed by matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) mass spectrometry. Using zinc oxo clusters as reaction precursors, high-quality InP QDs with a high photoluminescence quantum yield (PLQY) and a narrow full width at half-maximum (FWHM) were synthesized (green QDs: PLQY = 95%, FWHM = 37 nm; red QDs: PLQY = 84%, FWHM = 40 nm). The analysis results showed that improved optoelectronic properties were achieved by two important functions of the zinc oxo clusters: (1) suppressing the rapid depletion of the highly reactive phosphorus source and inducing size uniformity of the In(Zn)P core, and (2) facilitating the formation of an oxidized buffer layer, which effectively controls defects. Likewise, the use of reactivity-controlled species is an effective strategy for the synthesis of well-designed QDs.
Ultraviolet Light-Induced Mutants of Streptococcus lactis Subspecies diacetylactis with Enhanced Acid- or Flavor-Producing Abilities (1978)

A strain of Streptococcus lactis subspecies diacetylactis Sl isolated from fresh milk was exposed to 7200 ergs/ mm/ of ultraviolet radiation. Over 8100 colonies surviving from 7.4 x 106 cells exposed to radiation were screened on citrate agar for detection and isolation of mutants with increased flavor and/or acid production. Of the survivors, 960 were type-I mutants that exhibited clear zone on citrate agar after 18 h (presumed to be high diacetyl producers), and 288 were type-II mutants which did not exhibit clear zones on citrate agar for up to 72 h (high acid producers). Type-II mutants produced an average .93% titratable acidity which was 34% more than the .69% of the parent. Reduction in titratable acidity (56% less) was considerable in type-I mutants, compared with the parent culture. Diacetyl + acetoin production by type-I mutants was 137.9 ppm which has 4.5 times more than that of the parental strain. Acetaldehyde production in the mutants varied from 1.5 to 34.5 ppm (parent culture 3.0 ppm). The mutants with increased acid and high acetoin plus diacetyl production were stable after 50 subcultures in milk.
Amorphous metallizations for high-temperature semiconductor device applications (1981)

The initial results of work on a class of semiconductor metallizations which appear to hold promise as primary metallizations and diffusion barriers for high temperature device applications are presented. These metallizations consist of sputter-deposited films of high T sub g amorphous-metal alloys which (primarily because of the absence of grain boundaries) exhibit exceptionally good corrosion-resistance and low diffusion coefficients. Amorphous films of the alloys Ni-Nb, Ni-Mo, W-Si, and Mo-Si were deposited on Si, GaAs, GaP, and various insulating substrates. The films adhere extremely well to the substrates and remain amorphous during thermal cycling to at least 500 C. Rutherford backscattering and Auger electron spectroscopy measurements indicate atomic diffussivities in the 10 to the -19th power sq cm/S range at 450 C.
Metastable ferromagnetic phase formation in 35–50 at. % Mn—Ga thin films (1993)

Thin Mn—Ga films with the composition of 35–50 at. % Mn were fabricated by means of a conventional vacuum evaporation method on glass and NaCl substrates heated at 473 K. The metastable ferromagnetic phase was formed in the samples as well as the Mn2Ga5 phases. The analysis of the x-ray and microbeam electron diffraction patterns suggested that the crystal structure of this phase was correlated with a long-range ordered structure composed of a certain number of the Mn2Ga5 cell. It was demonstrated that the presence of the metastable phase affected the magnetic properties; the metastable single-phase films had a high coercivity up to about 320 kA/m and a fairly large saturation magnetization of about 550 mT, which were comparable to those for the MnGa-σ-phase and AlMn-τ-phase.
Strong Lower Bounds for Approximating Distribution Support Size and the Distinct Elements Problem (2009)

We consider the problem of approximating the support size of a distribution from a small number of samples, when each element in the distribution appears with probability at least $\frac{1}{n}$. This problem is closely related to the problem of approximating the number of distinct elements in a sequence of length n. Charikar, Chaudhuri, Motwani, and Narasayya [in Proceedings of the Nineteenth ACM SIGMOD–SIGACT–SIGART Symposium on Principles of Database Systems, 2000, pp. 268–279] and Bar-Yossef, Kumar, and Sivakumar [in Proceedings of the Thirty-Third Annual ACM Symposium on Theory of Computing, ACM Press, New York, 2001, pp. 266–275] proved that multiplicative approximation for these problems within a factor $\alpha>1$ requires $\Theta(\frac{n}{\alpha^2})$ queries to the input sequence. Their lower bound applies only when the number of distinct elements (or the support size of a distribution) is very small. For both problems, we prove a nearly linear in n lower bound on the query complexity, applicable even when the number of distinct elements is large (up to linear in n) and even for approximation with additive error. At the heart of the lower bound is a construction of two positive integer random variables, $\mathsf{X}_1$ and $\mathsf{X}_2$, with very different expectations and the following condition on the first k moments: $\mathsf{E}[\mathsf{X}_1]/\mathsf{E}[\mathsf{X}_2] = \mathsf{E}[\mathsf{X}_1^2]/\mathsf{E}[\mathsf{X}_2^2] = \cdots = \mathsf{E}[\mathsf{X}_1^k]/\E[\mathsf{X}_2^k]$. It is related to a well-studied mathematical question, the truncated Hamburger problem, but differs in the requirement that our random variables have to be supported on integers. Our lower bound method is also applicable to other problems and, in particular, gives a new lower bound for the sample complexity of approximating the entropy of a distribution.
Laser Doppler particle measuring system using nonsinusoidal forced vibration and bispectral analysis (1978)

A new laser Doppler particle measuring method which resists additive Gaussian noises is proposed. Particles are forced-vibrated by nonsinusoidal waves with fixed bispectral characteristics, and the responses are measured by using a velocity measuring system which consists of the optics of a laser Doppler velocimeter, FM discriminator, and a bispectral analyzer. Application of bispectral analysis is very effective in eliminating additive Gaussian noise even when the power of noise is fairly large. The principle, practical construction, and some experimental results are shown. The results show clearly the effectiveness of the method.
Optimal design for service resilience in ATM on SDH backbone networks (2002)

In order to improve the overall resilience of future ATM on SDH backbone networks in a cost-effective way, it is essential to follow an integrated-combining the ATM and SDH recovery schemes-survivability strategy. In this paper, we study several multi-layer recovery approaches to assure the resilience of ATM VPs in SDH on ATM transport networks against a set of important failures. Our study is supported by the results of a network planning case study, where we compared the investment cost of the multi-layer survivability strategies, in diverse network and traffic scenarios.
Spectral Dependence of Optical Reflection during Flow-Rate Modulation Epitaxy of GaAs by the Surface Photo-Absorption Method (1990)

Surface photo-absorption (SPA) is a newly developed in situ optical monitoring technique for the epitaxial growth process. This method is based on the reflectivity measurement of p-polarized incident light at the Brewster angle. This configuration minimizes the bulk GaAs contribution in light reflection. The small reflection light intensity change in the growing process is thus detected with a high signal-to-noise ratio. The spectral dependence of the SPA signal during flow-rate modulation epitaxy of GaAs was found to be composed of anisotropic and isotropic wavelength regions which correspond to the absorption spectra of surface chemical species. These spectra can be ascribed to the optical absorption of the chemical bond between surface Ga (or As) atom and underlying As (or Ga) plane with anisotropy and the optical absorption of the chemical bond related to the surface Ga atom, which is perpendicular to the (001) surface.
Synthesis and Structure of a Novel Lewis Acid−Base Adduct, (H<sub>3</sub>C)<sub>3</sub>SiN<sub>3</sub>·GaCl<sub>3</sub>, en Route to Cl<sub>2</sub>GaN<sub>3</sub> and Its Derivatives:  Inorganic Precursors to Heteroepitaxial GaN (1997)

The formation of a novel Lewis acid-base complex between the silyl azide Si(CH(3))(3)N(3) and GaCl(3) having the formula (H(3)C)(3)SiN(3).GaCl(3)()()(1) is demonstrated. The X-ray crystal structure of 1 shows that the electron-donating site is the nitrogen atom directly bonded to the organometallic group. Compound 1 crystallizes in the orthorhombic space group Pnma, with cell dimensions a = 15.823(10) Å, b = 10.010(5) Å, c = 7.403(3) Å, and Z = 4. Low-temperature decomposition of 1 via loss of (H(3)C)(3)SiCl yields Cl(2)GaN(3) (2), which serves as the first totally inorganic (C,H-free) precursor to heteroepitaxial GaN by ultrahigh-vacuum chemical vapor deposition. A volatile monomeric Lewis acid-base adduct of 2 with trimethylamine, Cl(2)GaN(3).N(CH(3))(3) (3), has also been prepared and utilized to grow high-quality GaN on Si and basal plane sapphire substrates. The valence bond model is used to analyze bond lengths in organometallic azides and related adducts.
Rocky Mountain Politics (1941)

Journal Article Rocky Mountain Politics. Edited by Thomas C. Donnelly. (Albuquerque: University of New Mexico Press, 1940. viii + 304 pp. Maps and bibliography. $3.00.) Get access LeRoy R. Hafen LeRoy R. Hafen State Historical Society of Colorado Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 27, Issue 4, March 1941, Page 652, https://doi.org/10.2307/1897992 Published: 01 March 1941