gebhart/patrepeval huggingface dataset:
Reactions of chlorosilanes with silica surfaces (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of chlorosilanes with silica surfacesMichael L. Hair and William HertlCite this: J. Phys. Chem. 1969, 73, 7, 2372–2378Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/j100727a046https://doi.org/10.1021/j100727a046research-articleACS PublicationsRequest reuse permissionsArticle Views1699Altmetric-Citations216LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Methamphetamine induces AP‐1 and NF‐κB binding and transactivation in human brain endothelial cells (2001)

Cellular and molecular mechanisms of methamphetamine (METH)-induced neurotoxicity may involve alterations of cellular redox status and induction of inflammatory genes in endothelial cells. To study these hypotheses, molecular signaling pathways of METH-induced inflammatory responses via activation of redox-sensitive transcription factors were investigated in human brain microvascular endothelial cells (HBMEC). A dose-dependent depletion of total glutathione levels was detected in HBMEC exposed to METH. In addition, electrophoretic mobility shift assay (EMSA) showed significant increases in DNA binding activities of redox-responsive transcription factors, AP-1 and NF-kappaB, in HBMEC treated with METH. METH-mediated AP-1 or NF-kappaB activation was accompanied by induction of transactivation of AP-1 or NF-kappaB, as measured by dual luciferase assay using specific reporter plasmids. Because NF-kappaB and AP-1 are known to regulate expression of inflammatory genes, expression of the gene encoding for tumor necrosis factor-alpha (TNF-alpha) was also studied in METH-treated HBMEC. A dose-dependent overexpression of the TNF-alpha gene was observed in HBMEC treated with METH. The importance of AP-1 and NF-kappaB in METH-induced TNF-alpha gene was confirmed in functional promoter studies using constructs of the TNF-alpha promoter with mutated AP-1 or NF-kappaB sites. These results indicate that METH-induced disturbances in cellular redox status and activation of AP-1 and NF-kappaB can play critical roles in the signaling pathways leading to upregulation of inflammatory genes in human brain endothelial cells.
Asymmetric Synthesis of Anti<i>N</i>-Boc-α-Hydrazino-β-Hydroxyesters from β-Ketoesters by Sequential Catalytic Hydrogenation and Electrophilic Amination (1993)

International audience
Hormonal Control of Epidermal Growth Factor Receptors by Gonadotropins during Granulosa Cell Differentiation (1987)

The hormonal induction of epidermal growth factor (EGF) receptor formation was analyzed during the maturation of granulosa cells obtained from diethylstilbestrol-implanted immature rats. In the absence of FSH, EGF receptors (as measured by the binding of [125I]iodo-EGF to the intact cells) rose by 50% at 6 h of culture, but then declined to about 25-40% of their initial levels at 24-96 h of culture. Scatchard analyses demonstrated the presence of high affinity EGF-binding sites in both freshly prepared cells and after FSH treatment. FSH stimulated a dose-dependent increase in the EGF receptor content of granulosa cells during a 96-h culture period. Concentrations of FSH as low as 2.5-5 ng/ml elevated EGF receptor levels 2- to 3-fold compared to those in untreated control cells, and 30 ng/ml FSH caused a maximal 15-fold rise. FSH increased EGF receptor levels approximately 2-fold in the first 6 h of culture and by up to 7-fold at 96 h compared to levels in freshly prepared cells. FSH treatment did not change the binding affinity (Kd = 5-6 X 10(-11) M) of the EGF receptor, but increased the total number of EGF-binding sites. The stimulatory effects of FSH on EGF receptor expression were mimicked by other cAMP-inducing ligands, including 8-bromo-cAMP, forskolin, and choleragen. Ligands known to inhibit granulosa cell function, including GnRH agonists and the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate, reduced the stimulation of EGF receptors by FSH. However, only 12-O-tetradecanoyl-phorbol 13-acetate suppressed the induction of EGF receptors by 8-bromo-cAMP. In granulosa cells cultured for 48 h with FSH, subsequent treatment with hCG for 24 h reduced EGF receptor content by 25%. Autoradiographic studies with [125I]iodo-EGF in ovarian thin sections demonstrated that EGF-binding sites were uniformly dispersed throughout the ovaries of diethylstilbestrol-implanted rats. Treatment with PMSG markedly increased EGF receptors in the outer walls of the growing follicles, while hCG treatment after PMSG caused a general decline in ovarian labeling. These results indicate that FSH maintains and increases the number of EGF receptors during granulosa cell differentiation, while LH/hCG reduces EGF-binding sites. Such changes in EGF receptors in the presence of endogenous growth factors may influence the number and selection of follicles destined for ovulation.
New antitumor imidazole derivative, 5-carbamoyl-1H-imidazol-4-yl piperonylate, as an inhibitor of purine synthesis and its activation by adenine phosphoribosyltransferase. (1982)

The mechanism of action of 5-carbamoyl-1H-imidazol-4-yl piperonylate (SL-1250), which has a broad antitumor spectrum, was examined by in vitro cell culture and enzymatic studies. In the serum-containing culture medium, SL-1250 was rapidly deacylated to 4-carbamoylimidazolium 5-olate (SM-108). Thus, SL-1250 might be acting on the cells in the form of SM-108. The growth of L5178Y cells was completely inhibited by 10(-5) M SL-1250. It should be noted that this growth inhibition was significantly reversed in the presence of equimolar concentrations of guanine, guanosine, or guanosine 5'-monophosphate to those of SL-1250. However, hypoxanthine and xanthine were not effective. These effects of purine addition were observed to be quite similar in growth inhibition by SM-108. It was found that inosine 5'-monophosphate dehydrogenase (EC 1.2.1.14; IMP dehydrogenase), a key enzyme of de novo purine synthesis, from Ehrlich carcinoma cells was inhibited by SM-108 only when 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) and MgCl2 coexisted with SM-108. In contrast, a chemically synthetic ribonucleotide of SM-108 inhibited IMP dehydrogenase without PRPP and MgCl2, and the mode of inhibition was competitive with the Ki value of 2 x 10(-8) M. On the other hand, the inhibition of either growth of L5178Y cells or IMP dehydrogenase in the presence of PRPP and MgCl2 by these compounds was reversed by adenine. A nucleotide of SM-108 was chromatographically identified when [14C]SM-108 was incubated in the enzyme solution with PRPP and MgCl2. This conversion by enzyme was also inhibited by adenine. Viewed together, these results strongly suggest that SL-1250 is, after being converted to SM-108, activated to its nucleotide form by adenine phosphoribosyltransferase (EC 2.4.2.7) and that this SM-108 nucleotide blocks de novo synthesis of guanosine 5'-monophosphate by inhibiting IMP dehydrogenase.
Diagnostic Accuracy of Fingerstick β-Hydroxybutyrate for Ketonuria in Pregnant Women With Nausea and Vomiting (2013)

Fingerstick β-OHB is a rapid and reliable diagnostic tool that correlates well with ketonuria and identifies ketonemia in pregnant women with nausea and vomiting. Fingerstick β-OHB testing has the potential to increase triage efficiency, shorten length-of-stay times, and positively affect patient outcomes in an ED setting.
Soil redistribution and pedologic transformations in coastal plain croplands (1999)

In agricultural basins of the southeastern coastal plain there are typically large disparities between upland soil erosion and sediment delivered to streams. This suggests that colluvial storage and redistribution of eroded soil within croplands is occurring, and/or that processes other than fluvial erosion are at work. This study used soil morphology and stratigraphy as an indicator of erosion and deposition processes in a watershed at Littlefield, North Carolina. Soil stratigraphy and morphology reflect the ways in which mass fluxes associated with cultivation transform the local soils. Fluvial, aeolian and tillage processes were all found to be active in the redistribution of soil. The soil transformations are of five general types. First, erosion and compaction in the cultivated area as a whole result in the thinning of Arenic and Grossarenic Paleudults and Paleaquults to form Arenic, Typic and Aquic Paleudults and Paleaquults. Second, redistribution of surficial material within the fields results in transitions between Arenic and Typic or Aquic subgroups as loamy sand A and E horizons are truncated or accreted. Third, aeolian deposition at forested field boundaries leads to the formation of compound soils with podzolized features. Fourth, sandy rill fan deposits at slope bases create cumulic soils distinct from the loamy sands of the source area or the darker, finer terrace soils buried by the fan deposits. Finally, tillage and fluvial deposition in upland depressions results in the gradual burial of Rains (poorly drained Typic Paleaquults) soils. Results confirm the importance of upland sediment storage and redistribution, and the role of tillage and aeolian processes as well as fluvial processes in the region. Copyright © 1999 John Wiley & Sons, Ltd.
Role of tachykinin receptors and melatonin in oxitocin secretion from isolated rat hypothalmo-neurohypophysial system. (2004)

Present investigations were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on oxytocin (OT) release from isolated rat hypothalamo-neurohypophysial (H-N) system as well as to determine whether the tachykinin NK-1 and/or NK-2 receptors contribute to the response of oxytocinergic neurons to melatonin. The results show, for the first time, that highly selective NK-1 receptor agonist, i.e., [Sar(9),Met(O(2))(11)]-Substance P, enhances while the NK-1 receptor antagonist (Tyr(6),D-Phe(7),D-His(9))-Substance P (6-11) - sendide - diminishes significantly OT secretion; the latter peptide was also found to antagonize the substance P-induced hormone release from isolated rat H-N system, when used at the concentration of 10(-7) M/L. Melatonin significantly inhibited basal and substance P-stimulated OT secretion. Neurokinin A and the NK-2 receptor selective agonist (beta-Ala(8))-Neurokinin A (4-10) as well as the NK-2 receptor antagonist (Tyr(5),D-Trp(6,8,9),Lys-NH(2)(10))-Neurokinin A (4-10) were essentially inactive in modifying OT release from the rat H-N system in vitro. The present data indicate a distinct role for tachykinin NK-1 (rather than NK-2) receptor in tachykinin-mediated regulation of OT secretion from the rat H-N system. Under present experimental conditions, however, a role of respective tachykinin receptors in the response of oxytocinergic neurons to melatonin has not been found.
The Role of Gut Hormone Peptide YY in Energy and Glucose Homeostasis: Twelve Years On (2013)

Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced. In recent years, insights from mechanistic studies in patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging studies, and from exercise research have greatly added to the field, and these areas provide the focus of discussion for this narrative review. We critically discuss recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role of PYY in glucose homeostasis, the role of hepatoportal PYY in mediating its central physiological effects, the specific modulation of brain regions by PYY, and the exercise-induced PYY response.
Network-on-Chip Multicast Architectures Using Hybrid Wire and Surface-Wave Interconnects (2016)

The network-on-chip (NoC) has been introduced as an efficient communication backbone to tackle the increasing challenges of on-chip communication. Nevertheless, merely metal-based NoC implementation offers only limited performance and power scalability in terms of multicast and broadcast traffics. To meet scalability demands, this paper addresses the system-level challenges for intra-chip multicast communication in a proposed hybrid interconnects architecture. This hybrid NoC combines and utilizes both regular metal on-chip interconnects and new type of wireless-NoC (WiNoC) which is Zenneck surface wave interconnects (SWI). Moreover, this paper embeds novel multicast routing and arbitration schemes to address system-level multicast-challenges in the proposed architecture. Specifically, a design exploration of contention handling in SWI layer is considered in both centralized and decentralized manners. Consequently, the hybrid wire-SWI architecture avoids overloading the network, alleviates the formation of traffic hotspots and avoid deadlocks that are typically associated with state-of-the-art multicast handling. The evaluation is based on a cycle-accurate simulation and hardware description. It demonstrates the effectiveness of the proposed architecture in terms of power consumption (up to around 10x) and performance (around 22x) compared to regular NoCs. These results are achieved with negligible hardware overheads. This study explore promising potential of the proposed architecture for current and future NoC-based many-core processors.
Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity (2018)

This study indicates that FRI is a superior tool than FVC in capturing of early and clinically relevant, disease progression in a regional manner.
Palladium-Catalyzed Direct <i>N</i>-Arylation of Nucleosides, Nucleotides, and Oligonucleotides for Efficient Preparation of dG−<i>N</i><sup>2</sup> Adducts with Carcinogenic Amino-/Nitroarenes (2006)

A method for direct palladium-catalyzed N-arylation reaction of nucleobases was developed for the convenient synthesis of DNA adducts with carcinogenic compounds. Using xantphos as the phosphine ligand and tetraethylammonium fluoride as the base in DMSO, several o-iodonitroarenes could be efficiently coupled with 2'-deoxyguanosine, 2'-deoxyadenosine, and 2'-deoxycytidine. The presence of a 3'-phosphate group in the deoxyribose moiety was found to be compatible with this N-arylation reaction; further, oligonucleotides could serve as substrates. The facile nitroreduction of the coupling compounds (12) yielded 2'-deoxyguanosin-N2-ylarylamine adducts, which are known to be biologically important. Compound 12 was easily converted to phosphoramidite derivatives, allowing the preparation of site-specific modified oligonucleotides with arylamine after the nitroreduction.
Seroepidemiologic Survey for Chlamydia suis in Wild Boar (Sus scrofa) Populations in Italy (2011)

We used serology to estimate the prevalence of exposure to chlamydiae in Italian populations of wild boars (Sus scrofa). Sera from 173 hunter-killed wild boars harvested during the 2006-2009 hunting seasons in three Italian regions were tested for antibodies to Chlamydia suis, Chlamydophila pecorum, Chlamydophila abortus, and Chlamydophila psittaci by the microimmunofluorescence test. Antibody titers to chlamydiae ≥ 1:32 were detected in 110 of the 173 samples tested (63.6%). Specific reactivity could be assessed only in 44 sera with antibody titers to C. suis that were two- to threefold higher than antibody titers against the other chlamydial species; the other 66 sera had similar reactivity against all the chlamydia species tested. Antibody to C. suis was detected in sera from wild boar populations with rare or no known contact with domestic pigs. These results suggest that the wild boar could be a chlamydia reservoir and may acquire chlamydiae independent of contacts with the domestic pig.
Simple layer-by-layer photonic crystal for the control of thermal emission (2005)

We present a theoretical and experimental study of a simple layer-by-layer photonic crystal structure designed for the control of the thermal emission in the infrared wavelength domain. We show that a relatively simple structure made of alternated ZnSe homogenous layers and gold microstructured grids can act as a thermal source itself giving us the unique opportunity to tailor its emission spectra. Comparisons between computed and measured transmission and emissivity spectra illustrate the relevance of our approach.
A study of fatty acid methyl esters with epoxy or alkyne functionalities (2001)

Abstract Described are the physical and chemical properties of the methyl esters of two uncommon fatty acids: vernolic acid, containing an epoxy group, and crepenynic acid, containing a triple bond. The incorporation of an epoxy or alkyne group into the fatty acid structure is shown to greatly affect the properties compared to conventional unsaturated fatty acids. The methyl esters have been characterized and compared with ordinary fatty acid methyl esters (i.e., methyl oleate and linoleate) with respect to spectroscopic characterization [ 1 H nuclear magnetic resonance (NMR)], 13 C NMR, and Fourier transform infrared), rheological properties, and oxidative reactivity (using chemiluminescence). Both methyl vernoleate and methyl crepenynate could successfully be produced by transesterification under basic conditions without reaction of the epoxy or alkyne groups. Rheological measurements showed that the methyl esters had a significantly lower viscosity compared to their triglyceride analogs. Smaller differences were seen when comparing the different methyl esters where methyl vernoleate had the highest viscosity due to the presence of the more polar oxirane group. Very large differences were found with respect to the oxidation rate of the different methyl esters. Methyl crepenynate was shown to oxidize extremely rapidly, whereas methyl vernoleate was very stable toward oxidation.
Stretchable biofuel cells as wearable textile-based self-powered sensors (2016)

Highly stretchable textile-based biofuel cells (BFCs), acting as effective self-powered sensors, have been fabricated using screen-printing of customized stress-enduring inks. Due to synergistic effects of nanomaterial-based engineered inks and the serpentine designs, these printable bioelectronic devices endure severe mechanical deformations, e.g., stretching, indentation, or torsional twisting. Glucose and lactate BFCs with the single enzyme and membrane-free configurations generated the maximum power density of 160 and 250 µW cm<sup>-2</sup> with the open circuit voltages of 0.44 and 0.46 V, respectively. The textile-BFCs were able to withstand repeated severe mechanical deformations with minimal impact on its structural integrity, as was indicated from their stable power output after 100 cycles of 100% stretching. By providing power signals proportional to the sweat fuel concentration, these stretchable devices act as highly selective and stable self-powered textile sensors. Applicability to sock-based BFC and self-powered biosensor and mechanically compliant operations was demonstrated on human subjects. These stretchable skin-worn "scavenge-sense-display" devices are expected to contribute to the development of skin-worn energy harvesting systems, advanced non-invasive self-powered sensors and wearable electronics on a stretchable garment.
Characterization of plasma deposited hydrocarbon diffusion barriers for embolic foam devices (2015)

Shape memory polymer (SMP) containing medical implants that are delivered through catheters require controlled expansion times to prevent the device from binding in the delivery catheter. Delayed expansion can be accomplished using body temperature and moisture plasticization from the aqueous environment of the blood. Although bulk material approaches are effective at delaying the expansion rate, they often compromise the ultimate expansion volume, or necessitate temperatures above body temperature for actuation. These factors motivate material refinement beyond bulk chemistry changes to achieve nonlinear passive actuation profiles. In this work, plasma deposited hydrocarbon diffusion barriers enable a second degree of material expansion control, facilitating extended catheter delivery times for endovascular medical devices. Hydrocarbon plasma films polymerized from mixtures of acetylene, ethylene and propylene were deposited on silicon wafers and characterized using ellipsometry, static water contact angles, and x-ray photoelectron spectroscopy. Selected plasma processes were applied to polyurethane SMP foams and material performance was characterized using differential scanning calorimetry and unconstrained foam expansion in 37 °C water. These plasma films were found to increase surface hydrophobicity and delay the moisture plasticization rate of shape memory polymer embolic foams without altering bulk thermo-mechanical properties.
An Automatic Location and Recognition Method for Bank Card Number (2019)

The Optical Character Recognition (OCR) technology is widely used in intelligent identification of bank cards, since it can improve the work efficiency and user experience in mobile payment. Conventional methods have the problems of low recognition rate and location accuracy. Therefore, an automatic location and recognition method for bank card number is proposed. Firstly, novel Connected Text Proposal Network (CTPN) algorithm is improved to locate the bank card number. Then, the Convolutional Recurrent Neural Networks (CRNN) algorithm is optimized to identify the card number. Some experimental results show that the method has a high positioning accuracy and recognition rate.
Reliability simulator for interconnect and intermetallic contact electromigration (2002)

A previously developed model for predicting interconnect electromigration time-to-failure under arbitrary current waveforms is shown to be applicable to Al-W intermetallic contacts as well. This model is incorporated in a circuit electromigration reliability simulator which can (1) generate layout advisory for width and length of each interconnect, the safety factor of each contact and via in a circuit to meet user-specified reliability requirements and (2) estimate the overall circuit electromigration failure rate and/or cumulative percent failure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Efficient Synthesis of OpticallyActive<i>trans</i>-2-Aryl-2,3-dihydrobenzofuran-3-carboxylicAcid Esters via C-H Insertion Reaction (2003)

Optically active trans-2-Aryl-2,3-dihydrobenzofuran-3-carboxylic acid esters were synthesized by intramolecular C-H insertion reaction. Upon treatment with a catalytic amount of Rh2(R-DOSP)4, aryldiazoester 8c possessing a chiral auxiliary underwent C-H insertion reaction to give 9c in high yield and in high selectivity (84% yield, 86% de).