gebhart/patrepeval huggingface dataset:
Essais de l'appareil Milko-Scan 300 utilisé pour le dosage en série de la matière grasse et des protéines du lait (1976)

En 1964, Goulden dcrit une mthode permettant d'effectuer le dosage des matires grasses, des protines et du lactose dans le lait par spectrophotomtrie infra-rouge (I.R.).
Immunotoxicity screening of drugs and chemicals: value of contact hypersensitivity to picryl chloride in the mouse. (1985)

Contact hypersensitivity to picryl chloride in the mouse is proposed as a valuable tool for the in vivo immunotoxicological testing of new compounds. Reproducibility was found to be excellent. Results obtained in the present work with chlorpromazine, cyclophosphamide, diazepam, haloperidol, hydrocortisone, promethazine and lead acetate, nickel chloride and selenium were similar to those previously reported regarding the effects of these compounds on cell-mediated immunity.
Targets of Fibroblast Growth Factor 1 (FGF-1) and FGF-2 Signaling Involved in the Invasive and Tumorigenic Behavior of Carcinoma Cells (2004)

Fibroblast growth factor (FGF)-1 and -2 have potent biological activities implicated in malignant tumor development. Their autocrine and nonautocrine activity in tumor progression of carcinoma was investigated in the NBT-II cell system. Cells were manipulated to either produce and be autocrine for FGF-1 or -2 or to only produce but not respond to these factors. The autocrine cells are highly invasive and tumorigenic and the determination of specific targets of FGF/fibroblast growth factor receptor (FGFR) signaling was assessed. In vitro studies showed that nonautocrine cells behave like epithelial parental cells, whereas autocrine cells have a mesenchymal phenotype correlated with the overexpression of urokinase plasminogen activator receptor (uPAR), the internalization of E-cadherin, and the redistribution of beta-catenin from the cell surface to the cytoplasm and nucleus. uPAR was defined as an early target, whereas E-cadherin and the leukocyte common antigen-related protein-tyrosine phosphatase (LAR-PTP) were later targets of FGF signaling, with FGFR1 activation more efficient than FGFR2 at modulating these targets. Behavior of autocrine cells was consistent with a decrease of tumor-suppressive activities of both E-cadherin and LAR-PTP. These molecular analyses show that the potential of these two growth factors in tumor progression is highly dependent on specific FGFR signaling and highlights its importance as a target for antitumor therapy.
Enzymic synthesis of pyrene-labeled polyphosphoinositides and their behavior in organic solvents and phosphatidylcholine bilayers (1990)

A method is reported for the synthesis of pyrene-labeled analogues of phosphatidylinositol 4-phosphate (Pyr-PIP) and phosphatidylinositol 4,5-biphosphate (Pyr-PIP2) from sn-2-(pyrenyl-decanoyl)phosphatidylinositol (Pyr-PI) using partially purified PI and PIP kinase preparations. Phosphorylation of Pyr-PI and Pyr-PIP was extensive (more than 50%) provided that the ATP concentration was high and that stabilizing agents such as sucrose and polyethylene glycol were present in the incubation medium. Pyr-PIP and Pyr-PIP2 were isolated by chromatography on immobilized neomycin. The identity of the products was established by thin-layer chromatography, UV-absorption spectroscopy, and spectrofluorometry. The pyrene excimer/monomer fluorescence technique revealed that, in contrast to Pyr-PI, Pyr-PIP and Pyr-PIP2 formed clusters in organic solvents. By use of the same technique for model membranes, it was shown that in phosphatidylcholine bilayers the collision frequency of the three fluorescent phosphoinositides decreased in the order PI greater than PIP greater than PIP2. Addition of Ca2+ at concentrations above 0.1 mM increased the collision frequency of Pyr-PIP2 and, to a much lesser extent, Pyr-PIP; Ca2+ had no effect on Pyr-PI.
Epidemiology of paediatric trauma admissions at Queen Elizabeth Central Hospital, Blantyre (2005)

We conducted an audit of paediatric trauma admissions to QECH, Blantyre, in September 2003. There were 107 trauma cases representing 8.8% of all paediatric admissions and mean age was 6 years. The commonest cause of trauma was falls (42.9%) followed by burns (31.8%) and road traffic accidents (14.9%). Of the road traffic accidents, only one case was a passenger, the rest were pedestrians hit by moving vehicles. Fracture of limbs was the commonest injury sustained (44.9%) and burns the second commonest injury (31.8%). Most (52.6%) children were brought into hospital within 24 hours of injury while 26.3% came in between 24 hours and 48 hours and 21.1% after 48 hours or more. Death occurred in 7.5% of cases. The mean number of days in hospital was 8.9 days.
Cationic Liposome-Mediated Gene Delivery <i>In vivo</i> (2002)

Several improvements have been made in liposomal delivery, thus making this technology potentially useful for treatment of certain diseases in the clinic. Success in non-viral delivery is complicated and requires optimization of several components. These components include nucleic acid purification, plasmid design, formulation of the delivery vehicle, administration route and schedule, dosing, detection of gene expression, and others. With further improvements, broad use of non-viral delivery systems to treat human disorders should be possible.
Nucleosides. 108. Ribo-xylo interconversions of 6,5'-cyclopyrimidine nucleosides via autoxidation and retro-aldol reactions (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleosides. 108. Ribo-xylo interconversions of 6,5'-cyclopyrimidine nucleosides via autoxidation and retro-aldol reactionsBrian A. Otter, Elvira A. Falco, and Jack J. FoxCite this: J. Org. Chem. 1978, 43, 3, 481–486Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://doi.org/10.1021/jo00397a022Request reuse permissionsArticle Views143Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (811 KB) Get e-Alertsclose Get e-Alerts
Aminoglycoside ototoxicity (2007)

There are currently no recommendations for pretreatment or posttreatment therapies to attenuate ototoxicity associated with aminoglycoside antibiotics. Our understanding of the mechanisms of ototoxicity has improved and apoptotic pathways are clearly responsible for hair cell demise. Further studies are necessary before significant improvement in hearing outcome can be expected after use of ototoxic antibiotics.
Vps9p CUE Domain Ubiquitin Binding Is Required for Efficient Endocytic Protein Traffic (2003)

Rab5 GTPases are key regulators of protein trafficking through the early stages of the endocytic pathway. The yeast Rab5 ortholog Vps21p is activated by its guanine nucleotide exchange factor Vps9p. Here we show that Vps9p binds ubiquitin and that the CUE domain is necessary and sufficient for this interaction. Vps9p ubiquitin binding is required for efficient endocytosis of Ste3p but not for the delivery of the biosynthetic cargo carboxypeptidase Y to the vacuole. In addition, Vps9p is itself monoubiquitylated. Ubiquitylation is dependent on a functional CUE domain and Rsp5p, an E3 ligase that participates in cell surface receptor endocytosis. These findings define a new ubiquitin binding domain and implicate ubiquitin as a modulator of Vps9p function in the endocytic pathway.
Plasmid DNA in a groundwater aquifer microcosm ‐adsorption, DNAase resistance and natural genetic transformation of <i>Bacillus subtilis</i> (1993)

Prokaryotes can exchange chromosomal and plasmid genes via extracellular DNA in a process termed genetic transformation. This process has been observed in the test tube for several bacterial species living in the environment but it is not clear whether transformation occurs in natural bacterial habitats. A major constituent of terrestrial environments are solid particles such as quartz, silt and clay, which have considerable surface areas and which make up the solid-liquid interfaces of the habitat. In previous experiments the adsorption of DNA to chemically purified quartz and clay minerals was shown and the partial protection of adsorbed DNA against DNAase I. In a microcosm consisting of natural groundwater aquifer material (GWA) sampled directly from the environment and groundwater (GW) both linear duplex and supercoiled plasmid DNA molecules bound rapidly and quantitatively to the minerals. The divalent cations required to form the association were those present in the GWA/GW microcosm. The association was stable to extended elution over one week at 23 degrees C. Upon adsorption, the DNA became highly resistant against enzymatic degradation. About 1000 times higher DNAase I concentrations were needed to degrade bound DNA to the same extent as DNA dissolved in GW. Furthermore, chromosomal and plasmid DNA bound on GWA transformed competent cells of Bacillus subtilis. However, in contrast to DNA in solution, on GWA the chromosomal DNA was more active in transformation than the plasmid DNA. The studies also revealed that in the transformation of B. subtilis Mg2+ can be replaced by Na+, K+ or NH4+. The observations suggest that in soil and sediment environments, mineral material with inorganic precipitates and organic matter can harbour extracellular DNA leaving it available for genetic transformation.
On the computational complexity of analyzing Hopfield nets (1989)

We prove that the problem of counting the number of stable states in a given Hopfield net is #P-complete, and the problem of computing the size of the attraction domain of a given stable state is NP-hard. 1 Introduction A binary associative memory network, or &quot;Hopfield net&quot; [6], consists of n fully interconnected threshold logic units, or &quot;neurons&quot;. Associated to each pair of neurons i; j is an interconnection weight w ij , and to each neuron i a threshold value t i . At any given moment a neuron i can be in one of two states, x i = 1 or x i = \\Gamma1. Its state at the next moment depends on the current states of the other neurons and the interconnection weights; if sgn( P n j=1 w ij x j \\Gamma t i ) 6= x i , the neuron may switch to the opposite state. (Here sgn is the signum function, sgn(x) = 1 for x 0, and sgn(x) = \\Gamma1 for x ! 0.) Whether the state change actually occurs depends on whether the neuron is selected for updating at this moment. In the synchronous update rule, al...
A class of liquid anode for rechargeable batteries with ultralong cycle life (2017)

Low cost, highly efficient and safe devices for energy storage have long been desired in our society. Among these devices, electrochemical batteries with alkali metal anodes have attracted worldwide attention. However, the practical application of such systems is limited by dendrite formation and low cycling efficiency of alkali metals. Here we report a class of liquid anodes fabricated by dissolving sodium metal into a mixed solution of biphenyl and ethers. Such liquid anodes are highly safe and have a low redox potential of 0.09 V versus sodium, exhibiting a high conductivity of 1.2 × 10<sup>-2</sup> S cm<sup>-1</sup>. When coupled with polysulfides dissolved in dimethyl sulfoxide as the cathode, a battery is demonstrated to sustain over 3,500 cycles without measureable capacity loss at room temperature. This work provides a base for exploring a family of liquid anodes for rechargeable batteries that potentially meet the requirements for grid-scale electrical energy storage.
Expression of hypoxia-inducible factor 1? in brain tumors (2000)

In GBMs, the heterogeneous pattern of HIF-1alpha expression appears to be determined at least in part by tissue oxygenation, whereas in HBs the homogeneous expression of HIF-1alpha may be driven by an oncogenic rather than a physiologic stimulus.
Probabilistic Estimation Mechanisms And Tesselated Representations For Sensor Fusion (1989)

Two fundamental issues in sensor fusion are (1) the definition of model spaces for representing objects of interest and (2) the definition of estimation procedures for instantiating repre-sentations, with descriptions of uncertainty, from noisy observa-tions. In 3-D perception, model spaces frequently are defined by contour and surface descriptions, such as line segments and planar patches. These models impose strong geometric limitations on the class of scenes that can be modelled and involve segmentation decisions that make model updating difficult. In this paper, we show that random field models provide attractive, alternative representations for the problem of creating spatial descriptions from stereo and sonar range measurements. For stereo ranging, we model the depth at every pixel in the image as a random variable. Maximum likelihood or Bayesian formulations of the matching problem allow us to express the uncertainty in depth at each pixel that results from matching in noisy images. For sonar ranging, we describe a tesselated spatial representation that encodes spatial occupancy probability at each cell. We derive a probabilistic scheme for updating estimates of spatial occupancy from a model of uncertainty in sonar range measurements. These representations can be used in conjunction to build occupancy maps from both sonar and stereo range measurements. We show preliminary results from sonar and single-scanline stereo that illustrate the potential of this ap-proach. We conclude with a discussion of the advantages of the representations and estimation procedures used in this paper over approaches based on contour and surface models.
The electroacoustic equations for a colloidal suspension (1990)

The term ‘electroacoustic’ is used in connection with phenomena that involve the interaction of sound waves and electric fields, such as the voltage difference generated across a transducer by the passage of a sound wave. This paper is concerned with electroacoustic effects in suspensions of electrically charged colloidal particles. The existing methods for calculating electroacoustic effects in suspensions are limited either to the dilute case, or to one particular effect, namely the open-circuit voltage generated between two parallel wire probes by a locally plane sound wave, propagating perpendicular to the wires. In this paper we present a procedure for calculating any electroacoustic effects in suspensions of arbitrary concentration. The only restriction on the method is that the particles must be small compared with the sound wavelength. The procedure involves the solution of a set of differential equations – referred to here as the ‘electroacoustic equations’ – for the macroscopic pressure, velocity and electrical potential in the suspension. The derivation of these equations and the associated boundary conditions form the major part of this paper. General features of the solution are also discussed, and an application is given involving a novel electroacoustic measurement.
Preparation of Y-Ba-Cu-O Thin Films by Rf-Magnetron Sputtering (1987)

Thin films of Y-Ba-Cu-O compound are prepared by rf-magnetron sputtering technique. Superconductivity appears for those films annealed at 900-930°C. The best thin films exhibit superconducting onset at 86 K and complete zero resistance at 76 K. From the X-ray diffraction analysis, it is found that the films annealed at 920°C have a strong c-axis orientation perpendicular to the film surface. The observed X-ray intensities are in good qualitative agreement with the calculated ones. The results of SEM and Auger electron spectroscopy are also presented.
Disubstitution of Cycloalkanones in the Mannich Reaction (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDisubstitution of Cycloalkanones in the Mannich ReactionF. F. BLICKE and F. J. McCARTYCite this: J. Org. Chem. 1959, 24, 8, 1069–1076Publication Date (Print):August 1, 1959Publication History Published online1 May 2002Published inissue 1 August 1959https://pubs.acs.org/doi/10.1021/jo01090a009https://doi.org/10.1021/jo01090a009research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Screening for PTSD in a substance abuse sample: Psychometric properties of a modified version of the PTSD symptom scale self‐report (1998)

The high rate of posttraumatic stress disorder (PTSD) among substance use disorder (SUD) patients has been documented in research protocols, but there is evidence that it is markedly under-diagnosed in clinical settings. To address the need for a brief self-report measure to identify SUD patients who may benefit from further assessment and/or treatment for PTSD, the psychometric properties of a modified version of the PTSD Symptom Scale Self-Report (PSS-SR) were examined in a treatment-seeking SUD sample (N = 118). The modified version of the PSS-SR, which measures both frequency and severity of PTSD symptoms, demonstrated good internal consistency reliability and was correlated with other self-report measures of trauma-related symptomatology. Comparisons between a structured PTSD diagnostic interview and the modified PSS-SR indicated that 89% of the PTSD positive patients were correctly classified by the modified PSS-SR. The clinical relevance of these findings was discussed.
Comparison of the efficacy of fibrates on hypertriglyceridemic phenotypes with different genetic and clinical characteristics (2010)

These results indicate that genetic factors known to contribute to the etiology and clinical expression of hypertriglyceridemia subtypes also modulate the response to triglyceride-lowering drugs.
Intracellular proteins displayed on the surface of tumor cells as targets for therapeutic intervention with antibody-related agents. (2011)

The identification of targets which are located intracellularly in normal cells and are exposed on the surface of malignant cells is an issue in the target selection process for the development of anticancer agents. Targets with these characteristics should increase the specificity of intervention and the corresponding therapeutic window. We discuss targets such as heat-shock protein 70 (HSP70) and heat-shock protein 90 (HSP90), glucose-regulated protein 78 (GRP78), actin, cytokeratins, vimentin, nucleolin, nucleosomes, estrogen receptor-alpha variant 36 (ER-α36) and feto-acinar pancreatic protein (FAPP). Involvement of these targets in cellular processes, tumor specificity and tractability with antibody-related agents, are discussed.
Influence of intrauterine saline infusion upon the oestrous cycle of the mare. (1975)

The effect of intrauterine saline on reproductive function was studied by infusion of mares in anoestrus, dioestrus, oestrus and prolonged dioestrus. Anoestrous mares were unaffected except near the beginning and end of the breeding season when anovulatory heats were induced. Dioestrous mares infused between Days 5 and 9 returned to heat an average of 3-8 days earlier than expected, and infusions during dioestrus were followed by ovulatory heats of normal fertility. Three mares in prolonged dioestrus showed ovulatory heats within 3 to 9 days of infusion. Infusions during oestrus had no appreciable effect. Repeated infusions were clinically harmless but post-infusion bacteriological swabs from the uterus were positive. In two cases studied, infusion was followed by a fall in peripheral plasma progestagen concentrations. Evidence was obtained that vaginal and cervical dilatation and oxytocin were not involved in the mechanisms and it is postulated that the luteolytic effect of intrauterine saline is mediated by prostaglandin.
Effect of a Specific Endothelin Receptor A Antagonist on Glomerulonephritis of ddY Mice with IgA Nephropathy (1996)

The present study assessed renal endothelin (ET)-1, ET-3, and ET receptor A and B mRNA levels in ddY mice at 8, 40, and 60 weeks of age. The renal mRNA levels of ET-1 increased significantly in ddY mice as their nephritis progressed, reaching a 6.6-fold (p < 0.01) higher level by 60 weeks than in control ICR mice. Renal ET-3 mRNA levels, however, remained unchanged. The renal mRNA levels of ET receptor A and B in ddY mice increased gradually with the progression of nephritis, reaching 4.8- (p < 0.01) and 3.6-fold (p < 0.01) higher levels, respectively, at 60 weeks of age than found in control ICR mice. A positive correlation was noted between ET-1 and ET receptor mRNA levels and histopathological changes in renal tissues. In addition, we assessed whether a specific ET receptor A antagonist, FR 139317, affects the progression of glomerulonephritis in ddY mice. At 24 weeks of age (before glomerulonephritis developed), ddY mice were divided into two groups that received intraperitoneally either FR139317 or its vehicle (saline) daily for 36 weeks. The development of histopathological lesions and urinary protein excretion were suppressed by FR139317 treatment. These data suggest that ET families play a role in the progression of glomerulonephritis and that FR139317 treatment can be used therapeutically in ddY mice with IgA nephropathy.
FKBP12 Physically and Functionally Interacts with Aspartokinase in <i>Saccharomyces cerevisiae</i> (1997)

The peptidyl-prolyl isomerase FKBP12 was originally identified as the intracellular receptor for the immunosuppressive drugs FK506 (tacrolimus) and rapamycin (sirolimus). Although peptidyl-prolyl isomerases have been implicated in catalyzing protein folding, the cellular functions of FKBP12 in Saccharomyces cerevisiae and other organisms are largely unknown. Using the yeast two-hybrid system, we identified aspartokinase, an enzyme that catalyzes an intermediate step in threonine and methionine biosynthesis, as an in vivo binding target of FKBP12. Aspartokinase also binds FKBP12 in vitro, and drugs that bind the FKBP12 active site, or mutations in FKBP12 surface and active site residues, disrupt the FKBP12-aspartokinase complex in vivo and in vitro.fpr1 mutants lacking FKBP12 are viable, are not threonine or methionine auxotrophs, and express wild-type levels of aspartokinase protein and activity; thus, FKBP12 is not essential for aspartokinase activity. The activity of aspartokinase is regulated by feedback inhibition by product, and genetic analyses reveal that FKBP12 is important for this feedback inhibition, possibly by catalyzing aspartokinase conformational changes in response to product binding.