gebhart/patrepeval huggingface dataset:
Mutants of <i>Escherichia coli</i> Variably Resistant to Bacteriophage T1 (1966)

Carta, Guy R. (Rutgers, The State University, New Brunswick, N.J.), and Vernon Bryson. Mutants of Escherichia coli variably resistant to bacteriophage T1. J. Bacteriol. 92:1055-1061. 1966.-Mutants resistant to bacteriophage T1 were isolated from ultraviolet (UV)-irradiated cultures of Escherichia coli B/r, a UV-resistant variant. Bacterial populations derived from some of these mutants were partially but not completely resistant to the bacteriophage. Such mutants, designated variably resistant (B/r/1v), could not be obtained from E. coli B. Phage-free mutant populations taken from different stages in growth consisted of significantly different proportions of T1-resistant and T1-sensitive cells. The growth stage-dependent range of variation exceeded 1,000-fold. In broth cultures, the highest proportion of resistant cells consistently appeared at mid-log phase, and the highest proportion of sensitive cells at lag and stationary phases. Comparable evidence for environmentally dependent changes in host-cell phenotype was obtained by efficiency of plating and cloning efficiency analysis tests. Micromanipulation showed that, in clones growing in the presence of phage T1, sensitive bacteria appeared with high frequency and underwent lysis.
Corrosion-induced degradation of microelectronic devices (1996)

Light-induced changes in silicon nanocrystal based solar cells: Modification of silicon-hydrogen bonding
Dielectric Mixture Model for Asphalt-Aggregate Mixitures (1993)

An empirical mixture equation has been developed to calculate the dielectric permittivity of asphalt aggregate mixtures. Experimentally measured dielectric permittivities are compared with results calculated using this empirical mixture equation. Also, the experimental results are compared with those calculated using a few other well known dielectric mixture equations.
Gulls and Buoys (1974)

Introduction| December 01 1974 Gulls and Buoys: “an introduction to the remarkable range of pleasures available from the films of Robert Breer” Scott Hammen Scott Hammen Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1974) 2 (6): 2–4. https://doi.org/10.1525/aft.1974.2.6.2 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Scott Hammen; Gulls and Buoys: “an introduction to the remarkable range of pleasures available from the films of Robert Breer”. Afterimage 1 December 1974; 2 (6): 2–4. doi: https://doi.org/10.1525/aft.1974.2.6.2 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAfterimage Search This content is only available via PDF. © 1974 by The Regents of the University of California1974 Article PDF first page preview Close Modal You do not currently have access to this content.
Rapid and accurate left ventricular chamber quantification using a novel CMR segmentation algorithm: A clinical validation study (2010)

Among a broad series of consecutive patients undergoing CMR, automated LVEF by LV-METRIC was within 1 point of MT with processing time reduced 14-fold. Stroke volume by LV-METRIC yielded improved agreement with an independent standard of phase contrast imaging.
Process Analysis for Dimerization of Isobutene by Reactive Distillation (2006)

Alkylates are a class of probable replacements for MTBE as gasoline additives that can be produced by dimerization of isobutene (to isooctene) with subsequent hydrogenation. The characteristics of the dimerization reaction make it a potential candidate for reactive distillation. The dimer, being heavier than C4, can be maintained at a low concentration level in the reactive zone by simultaneous distillation, thereby suppressing the subsequent oligomer-producing reactions. In this work, the influence of important design and operating parameters on the performance of the reaction in a hybrid reactive distillation column is studied through process simulations. the results show that a high selectivity toward diisobutene can be achieved along with adequate temperature control in the presence as well as absence of polar components. Multiple steady states are observed in some cases that introduce additional complexities in the determination of the optimal windows for certain parameters. The process seems economically attractive, as it is capable of utilizing the existing reactive distillation assets and the feedstock for MTBE production by suitable revamping.
Phase 1 study of combination rituximab with apolizumab in relapsed/refractory B-cell lymphoma and chronic lymphocytic leukemia (2005)

6607 Background: Apolizumab (Apo), a humanized IgG1 mAb, targets ID10, and rituximab (R), a chimeric IgG1 mAb, targets CD20, both of which are expressed on normal and malignant B-cells. These mAb’s may induce apoptosis through direct signaling, ADCC and/or CDC, and in vitro studies suggest additive effects in B-cell lymphomas. Methods: We undertook a phase 1 study of R at 375 mg/m2 followed by Apo at 4 dose levels (0.5; 1.5; 3 and 5 mg/kg) on days 1–2 for 4 weekly doses. Due to DLT, the administration sequence of Apo and R was reversed during the study and re-escalation of Apo commenced. Cycles were repeated q3 months for up to 3 cycles in stable or responding pts. 3–10 pts were enrolled at each dose level and MTD was defined as 0–1 DLT in 6 pts. Results: Of 64 pts screened for ID10 expression, 49 (77%) were positive; FL 17/23 (74%); CLL/SLL 17/20 (85%); MCL 8/10 (80%); DLBCL 4/5 (80%) and other B-cell lymphomas 3/5 (60%). Characteristics of 29 enrolled pts include median (range) age 62 (28–76) and male sex 22 (76%). The median (range) prior chemotherapy regimens was 2 (1–9), and 22 (76%) pts had received R. Histologies include CLL/SLL in 10 (34%), FL in 9 (31%), MCL in 4 (14%), DLBCL in 4 (14%) and other B-cell lymphomas in 2 (7%) pts. There were 3, 10, 9 and 8 pts treated at dose levels 1, 2, 3 and 4, respectively. Pts received a median (range) of 4 (range 1–12) doses. DLT included hemolytic uremic syndrome (HUS) at dose levels 3 and 4 and grade 3 arterial thrombosis at dose level 2. ID10 was found on endothelial cells in some pts and may be implicated in HUS. Because Apo alone had not been reported to cause HUS, the last 7 pts were treated with Apo on day 1 and R on day 2. No further HUS has occurred. Of 24 evaluable pts, RR is 42% with 5 (21%) CR/CR(u)s and 5 (21%) PRs. In the 5 CRs, 4 pts had FL, 1 pt had CLL/SLL, and 3 pts (60%) had received prior R. Conclusions: Apo and R may induce endothelial injury through up-regulation of HLA-DR4. The RR and CR rates suggest this combination may be more effective than R alone. Accrual continues. No significant financial relationships to disclose.
Advances in High Voltage Engineering (2004)

This book addresses the very latest research and development issues in high voltage technology and is intended as a reference source for researchers and students in the field, specifically covering developments throughout the last decade.
Cross Layer Design of Wireless LAN for Telemedicine Application (2009)

Telemedicine system requires an acceptable network quality of service and cost. IEEE 802.11 wireless LAN technology has been developed to provide scalable and low cost network. For telemedicine applications however, the technology does not fulfill the quality of service requirement yet. In order to overcome this problem, a new cross layer design of wireless LAN is proposed. The design is based on IEEE 802.11 g standard with modification in datalink and physical layer. This has been implemented in NS2 simulation environment. The simulation has been performed to deliver the video data for telemedicine application. Simulation result shows that the new cross layer design has better network quality of service for PSNR (Peak Signal Noise Ratio) and delay values than the conventional wireless LAN. Thus, the new design has a potential to be used in telemedicine system.
Long Journey into Tunneling (1974)

I am, of course, deeply aware of important contributions made by many colleagues and my friends throughout this long journey. The subject of the second section was carried out when I was in Japan and all the rest (35) has been performed in the United States of America. Since my journey into tunneling is still continuing, I do not come to any conclusions in this talk. However, I would like to point out that many high barriers exist in this world: barriers between nations, races, and creeds. Unfortunately, some barriers are thick and strong. But I hope, with determination, we will find a way to tunnel through these barriers easily and freely, to bring the world together so that everyone can share in the legacy of Alfred Nobel.
Gas-Sensitive Photoconductivity of Porphyrin-Functionalized ZnO Nanorods (2012)

Hybrid materials based on wide band gap semiconductors and dye molecules are intensively studied for photovoltaic applications. However, these materials also possess interesting gas sensitivities, besides these photonic effects. In this Article, we report the study, under visible light illumination, of the porphyrin-functionalized ZnO nanorod photoconductivity changes, modulated by exposure to two volatile organic compounds, ethanol and triethylamine, chosen as model analytes. The sensitivity to triethylamine exceeds that to ethanol by more than two orders of magnitude, showing a selectivity that is not found in other porphyrin-based gas sensors. This feature could open the way to a novel generation sensors, where photoactivation plays a role in determining both sensitivity and selectivity of the resulting device.
Legal Question Answering System using Neural Attention (2018)

This year’s COLIEE has two tasks called phases 1 and 2. The phase 1 needs to find the relevant article given a query t2, and the phase 2 needs to answer whether the given query t2 is yes or no according to Japan civil law articles. This paper presents our proposals for the phase 2 task. Two methods are presented. The first goes along the standard method taken by many authors, such that the relevant article t1 is selected by the similarity to the query t2 at the requirement (condition) and the effect (conclusion) descriptions of the articles. The second is our new proposal, in which Neural Networks with attention mechanism are applied to all the civil law articles in deciding the truthness of the query t2. This method takes into account all the articles by properly calculating their weighted sum.
Efficient Conversion of Secret-shared Values Between Different Fields. (2008)

We show how to effectively convert a secret-shared bit b over a prime field to another field. If initially given a random replicated secret share this conversion can be done by the cost of revealing one secret shared value. By using a pseudo-random function it is possible to convert arbitrary many bit values from one initial random replicated share. Furthermore, we generalize the conversion to handle general values of a bounded size.
Computational Chemical Biology: Identification of Small Molecular Probes that Discriminate between Members of Target Protein Families (2011)

Research in chemical biology focuses on the use of small molecules to study protein functions and distinguish between different targets and their functional properties. In this context, it would be helpful to better understand which currently available active compounds have a potential to differentiate between different targets belonging to a protein family. Such compounds might be utilized as a starting point for the development of small molecular probes that distinguish one or more targets from others within a family of interest. To address this question, we have designed a computational approach for data mining that involves the generation and quantitative assessment of selectivity profiles for compounds active against a protein family. Selectivity profiles were generated and represented in a consistent manner, and an intuitive weighting scheme was applied to account for the target differentiation potential of individual compounds. Based on a thorough analysis of public domain compound data, we have prioritized currently available active small molecules that displayed a tendency to differentiate between targets belonging to 15 different families. We have been particularly interested in identifying compounds having the highest general target differentiation potential within a family (rather than identifying compounds that are selective for one target over one or more others). These compounds might be utilized in target profiling and as starting points for further chemical exploration and probe generation. A compendium of prioritized active compounds with informative selectivity profiles is provided.
Establishment of a mouse xenograft model for mycosis fungoides (2004)

Mycosis fungoides (MF) is the most frequent variant of cutaneous T-cell lymphomas (CTCLs). MF primarily involves the skin initially with patches and plaques. In later stages, cutaneous tumors develop and tumor cells may spread to lymph nodes and finally to visceral sites. Here, we describe an animal model for MF in immune-deficient nude mice, using the CTCL cell line MyLa. Subcutaneous transplantation of MyLa cells leads to the formation of cutaneous tumors in 80% of the mice (50/60 total). Spread of tumor cells to visceral sites was detected by immunohistochemistry and polymerase chain reaction (PCR)-based detection of specific T-cell receptor-gamma rearrangement. MyLa cells were found circulating in the blood, lymph nodes, and in blood vessels of heart, kidney, lung, and liver. In lung and liver tissue, tumor cells presented perivascular invasion, but no large secondary tumors developed. The nude mouse model described here will be a valuable test system for new therapeutic approaches for the treatment of MF and opens the unique opportunity to study the disease in vivo.
A Critical Comparison of Some Methods for Interpolation of Scattered Data (1979)

Abstract : This report is concerned with methods for solving the scattered data interpolation problem: Given points (X sub K, Y sub k, F sub k), k = 1, ..., N, construct a smooth function, F(x,y), so that F(X sub k, Y sub k) = F sub k, K = 1, ...,N. A comparison of 29 methods for solution of this problem has been made. Each of the methods is discussed and the results of extensive testing for their properties and appropriate values of their parameters is given. Both local and global methods are considered. Comparisons of timing, storage, accuracy, visual pleasantness of the surface, and ease of implementation are made. A large number (over 200) of pages of perspective plots of surfaces are given. Suggestions for improvement of some methods are made, and methods which have poor approximation properties are identified.
The speEspeD operon of Escherichia coli. Formation and processing of a proenzyme form of S-adenosylmethionine decarboxylase. (1987)

We have previously shown that the gene (speD) for S-adenosylmethionine decarboxylase is part of an operon that also contains the gene (speE) for spermidine synthase (Tabor, C. W., Tabor, H., and Xie, Q.-W. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 6040-6044). We have now determined the nucleotide sequence of this operon and have found that speD codes for a polypeptide of Mr = 30,400, which is considerably greater than the subunit size of the purified enzyme. Our studies show that S-adenosylmethionine decarboxylase is first formed as a Mr = 30,400 polypeptide and that this proenzyme is then cleaved at the Lys111-Ser112 peptide bond to form a Mr = 12,400 subunit and a Mr = 18,000 subunit. The latter subunit contains the pyruvoyl moiety that we previously showed is required for enzymatic activity. Both subunits are present in the purified enzyme. These conclusions are based on (i) pulse-chase experiments with a strain containing a speD+ plasmid which showed a precursor-product relationship between the proenzyme and the enzyme subunits, (ii) the amino acid sequence of the proenzyme form of S-adenosylmethionine decarboxylase (derived from the nucleotide sequence of the speD gene), and (iii) comparison of this sequence of the proenzyme with the N-terminal amino acid sequences of the two subunits of the purified enzyme reported by Anton and Kutny (Anton, D. L., and Kutny, R. (1987) J. Biol. Chem. 262, 2817-2822).
Validation of the 2-????Ct Calculation as an Alternate Method of Data Analysis for Quantitative PCR of BCR-ABL P210 Transcripts (2006)

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder that is characterized by the presence of a reciprocal translocation between chromosomes 9 and 22 and results in the formation of the Philadelphia (Ph1) chromosome and is present in most of CML patients. The Ph1 chromosome forms a chimeric gene that encodes an abnormal P210 mRNA transcript in most CML patients. Surveillance for minimal residual disease by detection of BCR/ABL transcripts is currently done mostly by quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR). Quantitation of BCR/ABL transcripts can monitor tumor load and the outcome of therapy. Absolute quantification determines the input copy number of the transcript of interest, usually by plotting the amount of PCR product onto a standard curve based on serial dilutions of the same product cloned in plasmids. Relative quantification describes the change in expression of the target gene in the patient sample relative to that of a control transcript by using the 2-DeltaDeltaCt calculation. The results of real-time RT-PCR for BCR/ABL transcripts are often analyzed by using plasmid DNA standard curves. In the present study, 79 BCR/ABL transcript-positive samples from CML patients who were being monitored for minimal residual disease by real-time quantitative RT-PCR were studied to determine whether the 2-DeltaDeltaCt approach was equivalent to the plasmid standard curve method. BCR/ABL P210 transcripts were quantitated using both the plasmid standard curve method and the 2-DeltaDeltaCt calculation. The comparison of both methods revealed a highly significant and linear correlation between the plasmid standard curve method and the 2-DeltaDeltaCt calculation (R2=0.98, P<0.0001). Furthermore, there was a reduction of preparation time, contamination risk, and reagent usage. The 2-DeltaDeltaCt calculation is a convenient alternative method to derive accurate quantitative information from real time PCR assays.
Quantitative Proteomics Analysis of Plasmodium vivax Induced Alterations in Human Serum during the Acute and Convalescent Phases of Infection (2017)

The radial distribution of Plasmodium vivax malaria burden has evoked enormous concern among the global research community. In this study, we have investigated the serum proteome alterations in non-severe vivax malaria patients before and during patient recuperation starting from the early febrile to the defervescence and convalescent stages of the infection. We have also performed an extensive quantitative proteomics analysis to compare the serum proteome profiles of vivax malaria patients with low (LPVM) and moderately-high (MPVM) parasitemia with healthy community controls. Interestingly, some of the serum proteins such as Serum amyloid A, Apolipoprotein A1, C-reactive protein, Titin and Haptoglobin, were found to be sequentially altered with respect to increased parasite counts. Analysis of a longitudinal cohort of malaria patients indicated reversible alterations in serum levels of some proteins such as Haptoglobin, Apolipoprotein E, Apolipoprotein A1, Carbonic anhydrase 1, and Hemoglobin subunit alpha upon treatment; however, the levels of a few other proteins did not return to the baseline even during the convalescent phase of the infection. Here we present the first comprehensive serum proteomics analysis of vivax malaria patients with different levels of parasitemia and during the acute and convalescent phases of the infection.
Clinical analysis of obstructive sleep apnea hypopnea syndrome in children (2015)

A case of obstructive sleep apnea hypopnea syndrome (OSAHS) in the Department of Otolaryngology of the Third Affiliated Hospital of Inner Mongolia Medical School was collected. The incidence of this disease is high, which seriously threatens the physical and mental health of children, but it has not been paid enough attention by medical workers and parents. We hope we can make early discovery and treatment, relieve upper airway obstruction factors, prevent and treat complications for children with OSAHS through the case analysis, so as to improve their quality of life.
Inhomogeneity Effects in Vapor Phase Polymerized PEDOT: A Tool to Influence Conductivity (2010)

Abstract Low‐MW urethanes were investigated to control domain formation as well as inhibiting cleavage reactions during vapor phase polymerization of PEDOT. A diurethanediol (DUDO) was identified as a highly efficient mediator for the process, resulting in PEDOT films exceeding conductivities of 1 000 S · cm −1 . All the urethanes investigated had the desired inhibiting effect on the polymerization, but all apart from DUDO also introduced unwanted domain formation on the micrometer scale. The addition of PEG generally improved conductivity by suppressing the domain formation and, with an optimized combination of DUDO and PEG, conductivities over 1 200 S · cm −1 were achieved. magnified image
Design of an in-wheel motor for a solar-poweredelectricvehicle (1998)

The design of an in-wheel electric motor for the solar-powered vehicle ‘Aurora’, entered in the 1996, 3010 km Darwin – Adelaide World Solar Challenge solar car race is described. Compared to other entrants in the race, the brushless DC motor is more efficient (97.5% compared to 92–95%) and lighter (8.3 kg compared to 12–16 kg) than all other direct-drive motors, and more efficient than all motor/gear combinations. This is achieved by the use of high flux-density rare-earth magnets, and computer aided optimisation of an axial-flux configuration consisting of a Halbach magnet array and an ironless air-gap winding.
Noradrenaline vs terlipressin in the treatment of type 2 hepatorenal syndrome: a randomized pilot study (2013)

The results of this randomized study suggest that terlipressin and noradrenaline are safe and effective in the treatment of type 2 HRS and baseline serum creatinine, urine output and urinary sodium are predictive of response. Noradrenaline is less expensive than terlipressin in the treatment of type 2 HRS (ClinicalTrials.gov, Number NCT01637454).
Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1 (2000)

Galectin-1 is a sugar binding protein specific for beta-galactosides and not requiring metal ions for binding activity. It exists as a soluble protein which forms a noncovalent homodimer and is expressed with a broad tissue distribution. Recently, galectin-1 has been shown to play a possible role in the immune system mediating apoptosis of activated T cells with indirect evidence suggesting that galectin-1 interacts with the heavily glycosylated, transmembrane, protein phosphotyrosine phosphatase CD45. The interaction of galectin-1 with purified lymphocyte cell surface proteins was studied using surface plasmon resonance in a BIAcoretrade mark. Galectin-1 was shown to bind CD45 and Thy-1 in a carbohydrate-dependent manner. Several galectin-1 molecules could bind each CD45 molecule. The dissociation constant of dimeric galectin-1 binding to CD45 was measured at approximately 5 microM, indicating the concentration at which cross-linking of cell surface glycoproteins by galectin-1 would occur. A possible role for galectin-1 in the organization of cell surface glycoproteins is discussed.