gebhart/patrepeval huggingface dataset:
Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain by the Bur1 Cyclin-Dependent Kinase (2001)

BUR1, which was previously identified by a selection for mutations that have general effects on transcription in Saccharomyces cerevisiae, encodes a cyclin-dependent kinase that is essential for viability, but none of its substrates have been identified to date. Using an unbiased biochemical approach, we have identified the carboxy-terminal domain (CTD) of Rpb1, the largest subunit of RNA polymerase II, as a Bur1 substrate. Phosphorylation of Rpb1 by Bur1 is likely to be physiologically relevant, since bur1 mutations interact genetically with rpb1 CTD truncations and with mutations in other genes involved in CTD function. Several genetic interactions are presented, implying a role for Bur1 during transcriptional elongation. These results identify Bur1 as a fourth S. cerevisiae CTD kinase and provide striking functional similarities between Bur1 and metazoan P-TEFb.
Exploring Prostate Cancer Genome Reveals Simultaneous Losses of PTEN, FAS and PAPSS2 in Patients with PSA Recurrence after Radical Prostatectomy (2015)

The multifocal nature of prostate cancer (PCa) creates a challenge to patients' outcome prediction and their clinical management. An approach that scrutinizes every cancer focus is needed in order to generate a comprehensive evaluation of the disease, and by correlating to patients' clinico-pathological information, specific prognostic biomarker can be identified. Our study utilized the Affymetrix SNP 6.0 Genome-wide assay to investigate forty-three fresh frozen PCa tissue foci from twenty-three patients. With a long clinical follow-up period that ranged from 2.0-9.7 (mean 5.4) years, copy number variation (CNV) data was evaluated for association with patients' PSA status during follow-up. From our results, the loss of unique genes on 10q23.31 and 10q23.2-10q23.31 were identified to be significantly associated to PSA recurrence (p < 0.05). The implication of PTEN and FAS loss (10q23.31) support previous reports due to their critical roles in prostate carcinogenesis. Furthermore, we hypothesize that the PAPSS2 gene (10q23.2-10q23.31) may be functionally relevant in post-operative PSA recurrence because of its reported role in androgen biosynthesis. It is suggestive that the loss of the susceptible region on chromosome 10q, which implicates PTEN, FAS and PAPSS2 may serve as genetic predictors of PSA recurrence after radical prostatectomy.
Targeting Antibiotic Resistance (2016)

Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health. The past decades have seen a dramatic worldwide increase in human-pathogenic bacteria that are resistant to one or multiple antibiotics. More and more infections caused by resistant microorganisms fail to respond to conventional treatment, and in some cases, even last-resort antibiotics have lost their power. In addition, industry pipelines for the development of novel antibiotics have run dry over the past decades. A recent world health day by the World Health Organization titled "Combat drug resistance: no action today means no cure tomorrow" triggered an increase in research activity, and several promising strategies have been developed to restore treatment options against infections by resistant bacterial pathogens.
Citrate-promoted helix formation in gelatin. The viscosity-time effect (1962)

Research Article| April 01 1962 Citrate-promoted helix formation in gelatin. The viscosity-time effect A COURTS A COURTS Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1962) 83 (1): 124–129. https://doi.org/10.1042/bj0830124 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation A COURTS; Citrate-promoted helix formation in gelatin. The viscosity-time effect. Biochem J 1 April 1962; 83 (1): 124–129. doi: https://doi.org/10.1042/bj0830124 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search © 1962 The Biochemical Society1962 Article PDF first page preview Close Modal You do not currently have access to this content.
Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. (2004)

By using evidence and consensus, recommendations for the treatment of key problems in ET have been issued. Statements are graded according to the strength of the supporting evidence and uncertainty is explicitly declared.
Demonstration of a Cooled Laminated Integral Axial Turbine (1978)

A low-cost, high-temperature axial turbine has been developed that demonstrates the feasibility of constructing a small, integral, cooled turbine using photoetched laminates bonded together to form a complete wheel. A turbine design was established utilizing a cooling scheme suitable for operation at 2600°F. The photoetch and bond-process parameters were optimized utilizing small bonding stacks. A full-size wheel blank was bonded, and the laminated wheel mechanical integrity was established by operation in a whirlpit test at design speed.
A New Method for Automated Dynamic Calibration of Tipping-Bucket Rain Gauges (1997)

Existing methods for dynamic calibration of tipping-bucket rain gauges (TBRs) can be time consuming and labor intensive. A new automated dynamic calibration system has been developed to calibrate TBRs with minimal effort. The system consists of a programmable pump, datalogger, digital balance, and computer. Calibration is performed in two steps: 1) pump calibration and 2) rain gauge calibration. Pump calibration ensures precise control of water flow rates delivered to the rain gauge funnel; rain gauge calibration ensures precise conversion of bucket tip times to actual rainfall rates. Calibration of the pump and one rain gauge for 10 selected pump rates typically requires about 8 h. Data files generated during rain gauge calibration are used to compute rainfall intensities and amounts from a record of bucket tip times collected in the field. The system was tested using 5 types of commercial TBRs (15.2-, 20.3-, and 30.5-cm diameters; 0.1-, 0.2-, and 1.0-mm resolutions) and using 14 TBRs of a single type (20.3-cm diameter; 0.1-mm resolution). Ten pump rates ranging from 3 to 154 mL min−1 were used to calibrate the TBRs and represented rainfall rates between 6 and 254 mm h−1 depending on the rain gauge diameter. All pump calibration results were very linear with R2 values greater than 0.99. All rain gauges exhibited large nonlinear underestimation errors (between 5% and 29%) that decreased with increasing rain gauge resolution and increased with increasing rainfall rate, especially for rates greater than 50 mm h−1. Calibration curves of bucket tip time against the reciprocal of the true pump rate for all rain gauges also were linear with R2 values of 0.99. Calibration data for the 14 rain gauges of the same type were very similar, as indicated by slope values that were within 14% of each other and ranged from about 367 to 417 s mm h−1. The developed system can calibrate TBRs efficiently, accurately, and virtually unattended and could be modified for use with other rain gauge designs. The system is now in routine use to calibrate TBRs in a large rainfall collection network at Yucca Mountain, Nevada.
The rat electroretinogram in combined zinc and vitamin A deficiency. (1987)

To assess the relative importance and interdependence of zinc and vitamin A in retinal function, a group of 36 male Wistar rats were raised in dim illumination and deprived of both zinc and vitamin A (Z-A-) for 90 days (Phase I) until they lost weight and showed signs of both vitamin A and zinc deficiency. Scotopic electroretinograms (ERGs) showed an average 1.5 log unit elevation in light intensity needed to elicit a 200 microV b-wave (criterion intensity) as compared to a control-pair-fed group of rats. Tissue samples from the Z-A- rats showed undetectable liver vitamin A (less than 10 micrograms/g) and a significantly decreased level of femur zinc compared to the control group (P = 0.02). There was photoreceptor outer segment degeneration and loss of cells in the outer nuclear layer of the retina. For Phase II the 24 surviving rats were randomized into three treatment groups--one group remained vitamin A-deficient (A-) but received zinc and retinoic acid, the second remained zinc-deficient (Z-) but received vitamin A and retinoic acid, and the third group was repleted with both zinc and vitamin A (Z+A+) and also received retinoic acid. ERGs were performed 30 and 60 days after randomization. The criterion intensity of the Z+A+ and Z- groups approached normal by 60 days, while that of the A- rats deteriorated a further 1.0 log unit. Histologic studies of the A- rats showed abnormalities in cornea, photoreceptor outer segments, and gut mucosa. All animals had testicular atrophy. Vitamin A repletion significantly reverses retinal degeneration from the Z-A- state even in the presence of moderate zinc deficiency. Zinc supplementation alone does not prevent ongoing retinal degeneration from severe vitamin A deficiency.
A novel secure virtual storage device scheme (2010)

Confidential data in our computer is always threatened by the risk of internal staff and external hacker. Secure document system may be a best solution to settle this problem and it is always too expensive and too complicated. The Paper researches the framework of current secure file system, and proposes a secure scheme of virtual storage device. Compared to the secure file system, the virtual storage device is less secure but much simpler in usage and less cost. The paper forwards implement of the virtual storage device, especially the key part. Moreover, we have also developed a prototype which could read and write properly with encryption and decryption. According to the result of test, the virtual storage device could get fast I/O speed and rigorous security.
6.33mW MPEG audio decoding on a multimedia processor (2006)

Low-power implementation techniques are used in the multimedia processor to achieve MPEG audio decoding in 6.33mW with a 1.1V supply. Three techniques are employed: a parallel processing DSP; dynamic voltage control using a multi-power domain; and a conditional pre-charge flip-flop. The processor occupies 6.5times6.5mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in 0.15μm 6M CMOS
The reverend Nicholas Doyle (1928)

Journal Article The reverend Nicholas Doyle Get access Fred R. Gale Fred R. Gale Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLV, Issue jul07, 7 July 1928, Page 9, https://doi.org/10.1093/nq/CLV.jul07.9c Published: 07 July 1928
A Simplified 4-Site Economical Intradermal Post-Exposure Rabies Vaccine Regimen: A Randomised Controlled Comparison with Standard Methods (2008)

Controlled-Trials.com ISRCTN 30087513.
An event-condition-action language for XML (2002)

XML repositories are now a widespread means for storing and exchanging information on the Web. As these repositories become increasingly used in dynamic applications such as e-commerce, there is a rapidly growing need for a mechanism to incorporate reactive functionality in an XML setting. Event-condition-action (ECA) rules are a technology from active databases and are a natural method for supporting suchfunctionality. ECA rules can be used for activities such as automatically enforcing document constraints, maintaining repository statistics, and facilitating publish/subscribe applications. An important question associated with the use of a ECA rules is how to statically predict their run-time behaviour. In this paper, we define a language for ECA rules on XML repositories. We then investigate methods for analysing the behaviour of a set of ECA rules, a task which has added complexity in this XML setting compared with conventional active databases.
Chemistry of the Silylamines. I. The Condensation of Monofunctional Silylamines with Monofunctional Silanols<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of the Silylamines. I. The Condensation of Monofunctional Silylamines with Monofunctional Silanols1RONALD M. PIKECite this: J. Org. Chem. 1961, 26, 1, 232–236Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://pubs.acs.org/doi/10.1021/jo01060a057https://doi.org/10.1021/jo01060a057research-articleACS PublicationsRequest reuse permissionsArticle Views368Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Time Compression Multiplexing for Loop Transmission of Speech Signals (1974)

This paper considers the use of time compression multiplexing (TCM) for telephone loop communications. The analysis treats TCM transmission degradations in general, and applies the results to telephone speech transmission. To gain an understanding of the nature of TCM degradations, transmission through a linear, time invariant network and demultiplexing is considered. The channel signals are then assumed to be wide-sense stationary random processes, and expressions for the spectral properties of the TCM distortion and interchannel crosstalk are determined. To accurately evaluate the performance of a TCM system, a practical and economical equalizer is proposed. It is designed to meet speech transmission requirements for the telephone loop plant. A worst case application is chosen to evaluate the system performance. The evaluation of the TCM transmission performance utilizes both the random signal model and a computer simulation using digitized speech. The random signal analysis shows that the spectra of the distortion and crosstalk are significant for human speech. Results of the digitized speech simulation demonstrate that the subjective effect of the signal distortion is not severe, but the crosstalk is somewhat intelligible and more severe than expected.
Effective Combination of Vertical and Horizontal Stereo Vision (2018)

In this paper, we propose to complement a horizontally aligned stereo rig with a vertically aligned one. Based on artificial and real camera images we show that certain image structures can be detected by only one of the setups. Actually, the depth of structures with significant gradients in just one direction can only be measured using cameras with an offset in the same direction. Thus, the joint usage of both setups allows for significantly increased robustness and reliability. Moreover, we propose an approach for the fusion of two disparity images gained from two stereo camera pairs with one common camera. The algorithm uses an approximation of the actually measured matching cost function. Thus it takes into account the present image structures and the capabilities of each particular stereo setup. Due to its mathematical simplicity, it can be computed within 1 ms for images with a size of 1164 × 335 pixel. The performance of the fusion is demonstrated using different real-world scenarios.
Characteristics of sensitometric curves of radiographic films (2003)

A new type of radiographic film, EDR (extended dose range) film, has been recently become available for film dosimetry. It is particularly attractive for composite isodose verification of intensity modulated radiation therapy because of its low sensitivity relative to the more common Kodak XV film. For XV film, the relationship between optical density and dose, commonly known as the sensitometric curve, depends linearly on the dose at low densities. Unlike XV film, the sensitometric curve of EDR film irradiated by megavoltage x rays is not linearly dependent on the dose at low densities. In this work, to understand the mechanisms governing the shape of the sensitometric curves, EDR film was studied with kilovoltage x rays, 60Co gamma rays, megavoltage x rays, and electron beams. As a comparison, XV film was also studied with the same beams mentioned above. The model originally developed by Silberstein [J. Opt. Soc. Am. 35, 93-107, 1945)] is used to fit experimental data. It is found that the single hit model can be used to predict the sensitometric curve for XV films irradiated by all beams used in this work and for EDR films exposed to kilovoltage x rays. For EDR film irradiated by 60Co gamma rays, megavoltage x rays, and electron beams, the double hit model is used to fit the sensitometric curves. For doses less than 100 cGy, a systematic difference between measured densities and that predicted by the double hit model is observed. Possible causes of the observed differences are discussed. The results of this work provide a theoretical explanation of the sensitometric behavior of EDR film.
Liquid phase epitaxy of GaP by a temperature difference method under controlled vapor pressure (1975)

A series of experiments have been done in which the properties of GaP grown by liquid phase epitaxy (LPE) have been varied by providing an additional source of phosphorus via the vapor phase. The quality of the crystals, as judged from gross defect features observed in etched cross sections, is a function of the amount of phosphorus added to the vapor phase.
Retroviral transfer of genes into erythroid progenitors derived from human peripheral blood. (1990)

Human erythroblasts are a logical target for studies of expression of transferred globin genes because high-level expression is a prerequisite for gene therapy of hemoglobinopathies. Early erythroid progenitors (erythroid burst-forming units, BFU-E) are readily available from human peripheral blood and can be cultured to produce erythroblasts. However, conditions for efficient transfer into these normal progenitors have not been previously described. Here we demonstrate efficient transfer of the neomycin resistance gene into human peripheral blood BFU-E using the retrovirus vector, N2. We show that liquid culture of mononuclear cells from peripheral blood for 18-24 h prior to retroviral infection leads to increased transfer efficiency of N2 as determined by G418 resistance, and we are able to detect viral DNA by polymerase chain reaction (PCR) analysis. In addition, a second retrovirus, beta(gamma)-SVX, prepared with a human beta-globin gene containing a gamma-globin second exon to facilitate transcript detection and the 3'-enhancer sequence, was also used to determine whether similar results could be obtained when more than one gene is transferred. Using the beta(gamma)-SVX virus, increased transfer efficiency into BFU-E was similarly found after liquid culture for up to 4 days. Expression of the transferred globin gene was also detected by PCR analysis of cDNA made from erythroblast RNA. The human peripheral blood BFU-E system described should allow determination of sequences required for high-level expression of transferred globin and other erythroid genes.
Polymorphisms in<i>PPAR</i>Genes (<i>PPARD</i>,<i>PPARG</i>, and<i>PPARGC1A</i>) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study (2013)

Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
Corn Stillage as a Feedstuff for Broilers and Turkeys (1997)

These experiments studied the effect of corn stillage in broiler and turkey starter diets and the efficacy of various products to preserve the resulting high-moisture diets. Corn stillage fed at an 8-10% level on a dry matter basis (DMB) supported broiler growth and feed conversion comparable to those obtained with the control diet. Turkey poults were able to consume a 16% corn stillage (DMB) diet with growth and feed conversion comparable to that of the control diet. Both broilers and turkeys reduced their drinking water intake to compensate for water consumed via the feed. This resulted in no change in broiler fecal moisture and only a 5% increase in turkey fecal moisture. Both 3% propionic acid and 3% Shield preservative were effective in preserving the high-moisture stillage diets. Aflaban preservative at 0.08% was not as effective as the other compounds tested in preserving the diets.
A microfluidic system enabling Raman measurements of the oxygenation cycle in single optically trapped red blood cells (2005)

Using a lab-on-a-chip approach we demonstrate the possibility of selecting a single cell with certain properties and following its dynamics after an environmental stimulation in real time using Raman spectroscopy. This is accomplished by combining a micro Raman set-up with optical tweezers and a microfluidic system. The latter gives full control over the media surrounding the cell, and it consists of a pattern of channels and reservoirs defined by electron beam lithography that is moulded into rubber silicon (PDMS). Different buffers can be transported through the channels using electro-osmotic flow, while the resonance Raman response of an optically trapped red blood cell (RBC) is simultaneously registered. This makes it possible to monitor the oxygenation cycle of the cell in real time and to investigate effects like photo-induced chemistry caused by the illumination. The experimental set-up has high potential for in vivo monitoring of cellular drug response using a variety of spectroscopic probes.