gebhart/patrepeval huggingface dataset:
Hematopoietic stem cell transplantation : overview for general pediatrician (2007)

Hematopoietic stem cell transplantation (HSCT) has expanded and evolved substantially in the last decades to treat various malignant and nonmalignant diseases. However, the conditioning regimen can lead to transplantation related death by major organ dysfunction, severe infection and bleeding. In the allogeneic setting, graft versus host disease may also develop, making post-transplant management complex. To overcome these problems, new stem cell sources, stem cell mobilizing agents and new skills, nonmyeloablative stem cell transplantation including reduced intensity stem cell transplantation has been introduced in clinical practice, but problems remained so far. Recipients of stem cell transplant may be severely immunocompromised for many months after transplantation. Furthermore, longtermcomplications (endocrine, metabolic, relapse, second malignancies, etc) can develop. Pediatrician is open called on to participate in the evaluation and consideration of patients for possible transplant and long-term follow-up of HSCT patients. This review is intended as a basic overview of HSCT relevant to general pediatrician.
Mating and Sex Peptide Stimulate the Accumulation of Yolk in Oocytes of <i>Drosophila Melanogaster</i> (1997)

Mating elicits two reactions in many insect females: egg deposition is increased and receptivity to males is reduced. Central to the control of receptivity and oviposition in Drosophila melanogaster is the sex peptide (SP), a 36-amino-acid peptide sex pheromone synthesized in the male accessory glands and transferred to the female during copulation. To identify regulatory mechanisms involved in the maintenance of the oviposition response, we have compared the effects of mating and SP application with respect to oogenesis. The distribution of the various stages of oogenesis in the ovary, yolk protein (YP) synthesis by the fat body, as well as YP content, uptake and synthesis by the ovary were investigated. Transcripts of the yolk protein genes (yp) were quantified by Northern blotting. Based on our results, we conclude that mating and SP injection into virgin females stimulate yp gene transcription in the fat body only moderately above the background level. However, uptake into the ovary and transcription of the yp genes in the ovary is strongly enhanced after either mating or SP injection. These data are supported by the finding that the abundance of the vitellogenic stage 10 oocytes is also increased. In contrast, early vitellogenic stages 8 and 9 of oogenesis are present in the same numbers in virgin, mated, and SP-injected females, which suggests a control point at about stage 9 determining vitellogenic oocyte progression. The finding that SP can elicit equally all changes observed after copulation suggests that in the sexually mature female it is the major component controlling and stimulating oogenesis after mating.
Low Complexity Detection Scheme for NOFDM Systems Based on ML Detection over Hyperspheres (2011)

Nonorthogonal Frequency Division Multiplexing (NOFDM) is a digital modulation technique that promises to provide extremely high spectral efficiencies. However, this modulation scheme is seldom used in practice due to the high computational complexity involved in decoding the received signal in the presence of noise. The basic aim of this paper is to reduce this decoding complexity. Here, we propose a low complexity detection algorithm which makes use of maximum likelihood (ML) decoding not over the entire signal constellation but over a proper subset of the constellation that lies on a hypersphere thereby reducing the computational complexity for decoding. Computational complexity has been evaluated for various values of transmitted power and the result has been plotted for both ML detection algorithm and the proposed algorithm at a fixed data rate. The BER performance for both the algorithms has also been compared at a fixed data rate and the result has been plotted. The results show that the proposed algorithm is far superior to ML detection algorithm in terms of computational complexity.
Characterization of a Single-chain Antibody to the β-Chain of the T Cell Receptor (1995)

In this report the VH and VL genes of the anti-T cell receptor (TCR) antibody KJ16, which recognizes the TCR V beta 8.1 and V beta 8.2 regions in mice, were cloned and expressed as a single-chain antibody (scFv) in Escherichia coli. A 29-kDa protein was obtained after renaturation from inclusion bodies. The KJ16 scFv had a relative affinity for the native TCR that was slightly higher than KJ16 Fab fragments. The scFv and Fab fragments of the KJ16 antibody, together with monovalent forms of two other anti-TCR antibodies, were evaluated as antagonists of the T cell-mediated recognition of a peptide-class I complex or of a superantigen, Staphylococcus enterotoxin B (SEB) bound to a class II product. Each of the anti-TCR antibodies was efficient at inhibiting the recognition of the SEB-class II complex. In contrast, only the clonotypic antibody, which binds to epitopes on both V beta and V alpha regions, inhibited the recognition of peptide-class I complex. We conclude that the TCR binding site for the SEB-class II ligand encompasses a larger surface area than the TCR binding site for the peptide-class I ligand.
ELECTRIC ANALGESIA, AND ELECTRIC RESUSCITATION AFTER HEART FAILURE UNDER CHLOROFORM OR ELECTROCUTION (1911)

Electric analgesia was applied successfully for the first time, in animal, then in human surgery, by myself. Successful local application of this analgesia in human surgery is reported by Dr. M. M. Johnson.<sup>1</sup>I administered this analgesia. I have reported successful application of this analgesia in animal surgery and electric sleep in clinical work in all the issues of the<i>Journal of Mental Pathology</i>, commencing with 1906. The part of this paper treating of electric analgesia and sleep will be published elsewhere for reason of want of space here. It is possible to resuscitate, by means of electric currents, subjects in a condition of apparent death caused by chloroform, ether, morphin, electrocution, etc. The first important researches into resuscitation of electrocuted subjects were made at about the same time by Professor Battelli<sup>2</sup>in Europe, and Dr. R. H. Cunningham, in this country.<sup>3</sup>Both authors used enormous currents
Brachiocephalic vessel: selective and superselective catheterization. (1983)

The development of a catheter for easy and reproducible selective and superselective catheterization of the distal branches of the brachiocephalic arteries is reported. The catheter consists of a proximal 6- or 7-F braided wire shaft and a distal, nonbraided 10 cm made of thin-walled polyurethane with a 4- or 5-F diameter. The most distal 1 cm has a 105-degree curve and is not tapered at the tip. In this series, 209 patients were embolized in 277 separate procedures. Catheterization of the desired vessel was achieved in more than 95% of cases.
Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to<i>Aspergillus fumigatus</i> (2010)

Dysregulation of the Th1/Th2 cytokine balance and a switch to a Th2 immune response contribute to the development of and the unfavorable outcome from invasive aspergillosis (IA). We explore in this paper the role of glycogen synthase kinase 3 (GSK-3) in human immature dendritic cells (iDCs) relative to infection caused by A. fumigatus by the use of GSK-3 inhibitors (LiCl, SB415286) and RNA interference technology. In iDCs exposed to A. fumigatus germ tubes, inhibition of GSK-3 with LiCl or SB415286, as well as transfection with small interfering RNA, led to markedly elevated expression of the anti-inflammatory cytokine IL-10. In contrast, pro-inflammatory cytokine response was only partially regulated by GSK-3. Screening of patients after allogeneic stem cell transplantation (with or without IA) for the presence of genetic markers (rs334558, rs6438552) in the GSK-3 gene revealed no significant association with an increased risk for IA. In conclusion, GSK-3 might be involved in the regulation of the anti-inflammatory response of iDCs in the context of infections due to A. fumigatus, albeit the exact mechanisms have to be clarified in future experiments.
Intrepid MicroTrack leaky cable sensor (2003)

Intrepid MicroTrack is the first leaky coaxial cable sensor to utilize FM CW radar techniques to detect and locate intruders. The first leaky coaxial cable sensor, introduced at the 1976 Carnahan Conference in Lexington, Kentucky, used pulse radar techniques to detect and locate intruders. Since then, there have been numerous papers on CW leaky cable sensors that detect, but do not locate intruders. Like Southwest Microwave's MicroPoint, the acoustic cable sensor introduced at the 1994 Carnahan conference, MicroTrack offers several new features, including the ability to precisely locate intruders. These features greatly improve sensor performance. This paper describes the technology and its broad range of applications including buried, surface and barrier mounted. MicroTrack is an ultra wide band (UWB) HF terrain-following radar. FM CW radar techniques are well known and have been widely used in radio altimeters and police radar for many years. However, it is only with the advent of low cost direct digital synthesis (DDS) chips, high speed and high resolution analog to digital converters (ADC) and digital processing components that it is now practical to apply FM CW radar techniques to leaky cables. MicroTrack uses a fast Fourier transform (FFT) to translate the swept frequency response into precise target location. The frequency diversity associated with the ultra wide bandwidth assures uniform detection along the length of the sensor cable. MicroTrack complies with radio regulatory requirements for low power swept frequency field disturbance sensors in the HF band.
L-Phenylalanine Mustard (L-PAM) in the Management of Primary Breast Cancer (1975)

Prolonged l-phenylalanine mustard (L-PAM) administration as an adjuvant to mastectomy in the management of patients with primary breast cancer and pathologically positive axillary nodes was evaluated by a prospective, randomized, clinical trial. Treatment failures occurred in 22 per cent of 108 patients receiving placebo and 9.7 per cent of 103 women given L-PAM (p = 0.01). A statistically significant difference (p = 0.02) existed in favor of L-PAM relative to disease-free interval. In premenopausal women, the difference with respect to disease-free interval of treated and control groups was highly significant (p = 0.008). A treatment failure occurred in 30 per cent of premenopausal patients receiving placebo and 3 per cent of those treated with L-PAM (p = 0.008). Whereas a similar trend was observed in postmenopausal patients, the difference is not statistically significant. Thus, L-PAM has been demonstrated to be effective in the treatment of women with primary breast cancer, particularly those who are premenopausal. Results were achieved with minimal undesirable side effects.
Solubility of different folding conformers of bovine growth hormone (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of different folding conformers of bovine growth hormoneDavid N. BremsCite this: Biochemistry 1988, 27, 12, 4541–4546Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/bi00412a048https://doi.org/10.1021/bi00412a048research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Blockade of B‐cell‐activating factor suppresses lupus‐like syndrome in autoimmune BXSB mice (2009)

B-cell-activating factor (BAFF), a member of the tumour necrosis factor superfamily, plays a critical role in the maturation, homeostasis and function of B cells. In this study, we demonstrated the biological outcome of BAFF blockade in BXSB murine lupus model, using a soluble fusion protein consisting of human BAFF-R and human mutant IgG4 Fc. Mutation of Leu(235) to Glu in IgG4 Fc eliminated antibody-dependent cell cytotoxicity (ADCC) and complement lysis activity, and generated a protein devoid of immune effector functions. Treatment of BXSB mice with BAFF-R-IgG4mut fusion protein for 5 weeks resulted in significant B-cell reduction in both the peripheral blood and spleen. Treated mice developed lower proteinuria, reduced glomerulonephritis and much delayed host death than untreated animals. Thus, BAFF blockade with BAFF-R-IgG4mut protein is an effective strategy to treat B-cell-mediated lupus-like pathology. Moreover, compared with other IgG isotypes with undesired effector functions, mutant IgG4 Fc should prove useful in constructing novel therapeutic reagents to block immune molecule signalling in various diseases.
Structural changes in the Ras protein revealed by fluorescence spectroscopy (2003)

The Y32W mutant of the Ras protein which has a tryptophan residue close to the guanine nucleotide binding site is studied using two fluorescence spectroscopic techniques. Two-dimensional mapping of all emission and all fluorescence spectra using excitation–emission spectroscopy (EES) in conjunction with time-resolved laser-induced fluorescence (LIF) is used to analyze and assign the contribution of the different fluorophores to the total fluorescence. Time-resolved LIF is shown to be a method that allows to follow the slight conformational changes of Ras binding to the nucleotides GDP, GTP, or the non-hydrolyzable analogues GppNHp, GppCH2p and GTP-γS and allows to distinguish between the active and inactive form. Additionally, a variant of the EES technique is used for the investigation of the intrinsic GTPase function of Ras and the determination of kinetic constants for this reaction.
An integrated multi-element ultra-thin-film gas analyzer (2003)

The authors reports a multi-element gas analyzer realized in silicon as the hybrid of two dual-element detector chips and a control/interface chip. The detectors utilize ultra-thin metal sensing films supported by a selectively micromachined dielectric window. Boron-diffused silicon heaters under the windows permit the window temperature to he varied between ambient and over 1000 degrees C with a heating efficiency in vacuum of 20 degrees C/mW. The detector control chip contains interface circuitry for four such detectors. Window temperature is controlled from ambient to 1200 degrees C with eight-bit accuracy. Film conductivity is similarly measured to eight-bit accuracy for full-scale resistances from 5 ohms to 1.3 Mohms. Film conductivity measurements (magnitude and phase) can be made from DC to 2 MHz using the on-chip circuitry. On the output side, the interface chip utilizes a standard eight-line interface to a VLSI microcontroller, allowing the implementation of the analyzer as a smart peripheral. The detectors are realized using a six-mask process while the control chip is implemented in an eleven-mask 2 mu m CMOS process in a die size of 4.4 mm*6.6 mm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
FAAD: face at a distance (2008)

The issues of applying facial recognition at significant distances are non-trivial and often subtle. This paper summarizes 7 years of effort on Face at a distance, which for us is far more than a fad. Our effort started under the DARPA Human Identification at a Distance (HID) program. Of all the programmers under HID, only a few of the efforts demonstrated face recognition at greater than 25ft and only one, lead by Dr. Boult, studied face recognition at distances greater than 50 meters. Two issues were explicitly studied. The first was atmospherics/weather, which can have a measurable impact at these distances. The second area was sensor issues including resolution, field-of-view and dynamic range. This paper starts with a discussion and some of results in sensors related issues including resolution, FOV, dynamic range and lighting normalization. It then discusses the "Photohead" technique developed to analyze the impact of weather/imaging and atmospherics at medium distances. The paper presents experimental results showing the limitations of existing systems at significant distance and under non-ideal weather conditions and presents some reasons for the weak performance. It ends with a discussion of our FASST<sup>TM</sup> (failure prediction from similarity surface theory) and RandomEyes<sup>TM</sup> approaches, combined into the FIINDER<sup>TM</sup> system and how they improved FAAD.
Biological Activity of Brain-derived Neurotrophic Factor with Mismatched Disulfide Linkages Produced by<i>Escherichia coli</i> (1996)

E. coli cells harboring an expression plasmid with a brain-derived neurotrophic factor (BDNF) gene obtained from rat BDNF cDNA were sonicated and centrifuged to obtain a precipitate containing BDNF. Ten different proteins of BDNF were purified from the precipitate and the three disulfide linkages of six proteins were identified. Those disulfide structures were different from that of authentic BDNF and the biological activities of BDNF with mismatched disulfide linkages (EC50 of 2 to 15 ng/ml) were much lower than that of authentic BDNF (EC50 of 30 pg/ml). The BDNF with mismatched disulfide linkages inhibited the biological activity of authentic BDNF.
Modulation of Mammalian <i>O</i><sup>6</sup>-Alkylguanine-DNA Alkyltransferase in vivo by <i>O</i><sup>6</sup>-Benzylguanine and its Effect on the Sensitivity of a Human Glioma Tumor to l-(2-chloroethyl)-3-(4-methylcyclohexyl)-l-nitrosourea (1990)

Experiments were carried out in mice and hamsters to determine whether the activity of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, in tissues and tumors was reduced by treatment with O6-benzylguanine in vivo. Following intraperitoneal injection of O6-benzylguanine, there was a rapid and complete loss of alkyltransferase activity in both livers and kidneys of mice and hamsters. The activity in mouse tissues was slowly restored, reaching pretreatment activities at 16 hr and 72 hr after injection of O6-benzylguanine at 10 mg/kg or 126 mg/kg, respectively. The activity in hamster liver was restored at a significantly lower rate, reaching less than 20% pretreatment activity 72 hr after treatment with 100 mg/kg of O6-benzylguanine. The efficient reduction of alkyltransferase activity by O6-benzylguanine was in sharp contrast to the inability of O6-methylguanine to bring about similar reductions. Activities dropped to about 55% of pretreatment activities in several mouse organs 4 hr after treatment with 126 mg/kg of O6-methylguanine compared to a more than 90% reduction in activity in animals after treatment with O6-benzylguanine. The sensitivity of SF767 cells to meCCNU after treatment with O6-benzylguanine was increased substantially. Furthermore, treatment of nude mice carrying SF767 tumor with 60 mg/kg of O6-benzylguanine prior to either 7.5 or 15 mg/kg of meCCNU led to significant inhibition of tumor growth. These studies indicate that O6-benzylguanine is a suitable compound for use in experiments to examine the role of the alkyltransferase protein in vivo in counteracting the effects of alkylating agents.(ABSTRACT TRUNCATED AT 250 WORDS)
Super-X divertors and high power density fusion devices (2009)

The Super-X Divertor (SXD), a robust axisymmetric redesign of the divertor magnetic geometry that can allow a fivefold increase in the core power density of toroidal fusion devices, is presented. With small changes in poloidal coils and currents for standard divertors, the SXD allows the largest divertor plate radius inside toroidal field coils. This increases the plasma-wetted area by 2–3 times over all flux-expansion-only methods (e.g., plate near main X point, plate tilting, X divertor, and snowflake), decreases parallel heat flux and hence plasma temperature at plate, and increases connection length by 2–5 times. Examples of high-power-density fusion devices enabled by SXD are discussed; the most promising near-term device is a 100 MW modular compact fusion neutron source “battery” small enough to fit inside a conventional fission blanket.
Use of a water hardness test kit to measure serum calcium concentration in cattle. (1999)

Results indicate that a commercially available water hardness test kit can be used as a rapid, inexpensive method of estimating serum calcium concentrations and diagnosing hypocalcemia in dairy cattle. However, the test is not practical for cow-side use, because blood samples must be centrifuged to obtain serum for use in the test kit.
Molecular diversity at the <em>Vat/Pm-W</em> resistance locus in melon (2008)

The resistance Vat gene of melon was isolated by map-based cloning. It encodes a protein with a coiled coil domain (CC), a nucleotide binding site (NBS) and leucine–rich repeats (LRR). Whereas most resistance genes confer resistance to a single pathogen, two alleles with different resistance specificities were identified at the locus. The Vat allele confers resistance to plant colonization by the aphid Aphis gossypii and to transmission of unrelated viruses by this vector specifically; the Pm-W allele confers resistance to the powdery mildew Podosphaera xanthii. Here we identified Vat-analogs in several melon genotypes using Long Range PCR, cloning and sequencing of full-length fragments. Several sources of variability were identified: (i) a different number of analogs were identified, suggesting a variable complexity of the gene cluster depending on the genotype, (ii) the number of repeats of a conserved motif of 65 amino acids within the LRR domain varied from two to five; this variation may be involved in the specific recognition of aphids or powdery mildew, (iii) finally, while the Vat allele seems to be shared by several aphid resistant accessions from various geographical origins, other alleles (genes) may be responsible for aphid resistance in some accessions; thus, a new putative allele was identified in the Indian accession 90625, which exhibits a resistance phenotype slightly distinct from that mediated by the Vat allele.
Real Time Prediction of Temperatures in an Induction Motor Using a Microprocessor (1988)

ABSTRACT The paper describes a microprocessor based thermal prediction device for induction motors, which has applications in ageing control and motor protection. A lumped parameter linear model is used to describe the dynamic thermal performance of an induction motor. The model is formulated out of purely dimensional information and constant thermal coefficients, to be applicable to any similar machine. The heat input is derived from measurements of the induction motor supply alone. The thermal model is solved in real time by a microprocessor, which estimates the motor's temperatures from the external inputs of motor phase current and ambient temperature. Results are presented for a 5.5 kW machine.