gebhart/patrepeval huggingface dataset:
Physiological identification of morphologically distinct afferent classes innervating the cristae ampullares of the squirrel monkey (1995)

1. Semicircular-canal afferents in the squirrel monkey were characterized by their resting discharge, discharge regularity, sensitivity to galvanic currents delivered to the ear (beta *), the gain (g2Hz), and phase lead (phi 2Hz) of their response to 2-Hz sinusoidal head rotations, and their antidromic conduction velocity. Discharge regularity was measured by a normalized coefficient of variation (CV*); the higher the CV*, the more irregular the discharge. g2Hz and phi 2Hz were expressed relative to angular head velocity. 2. These physiological measures were used in an attempt to discern the discharge properties of the three morphological classes of afferents innervating the crista. Presumed bouton (B) fibers were identified as slowly conducting afferents. Presumed calyx (C) fibers were recognized by their irregular discharge and low rotational gains. The remaining fibers were considered to be dimorphic (D) units. Single letters (B, C, and D) are used to emphasize that the classification is based on circumstantial evidence and may be wrong for individual fibers. Of the 125 identified fibers, 13 (10%) were B units, 36 (29%) were C units, and 76 (61%) were D units. 3. B units were regularly discharging D units ranged from regularly to irregularly discharging. C units were the most irregularly discharging afferents encountered. The mean resting discharge for the entire sample was 74 spikes/s. Resting rates were similar for regularly discharging B and D units and higher than those for irregularly discharging C and D units. 4. Except for their lower conduction velocities, the discharge properties of B units are indistinguishable from those of regularly discharging D units. Many of the discharge properties of B and D units vary with discharge regularity. There is a strong, positive relation when beta *, g2Hz, or phi 2Hz is plotted against CV*. For beta * or phi 2Hz, C units conform to the relation for B and D units. In contrast, values of g2Hz for C units are three to four times lower than predicted from the relation for the other two classes. 5. Internal (axon) diameters (dp) of peripheral vestibular-nerve fibers were estimated from central antidromic conduction velocities. Thick fibers (dp > or = 49 microns) were irregularly discharging, mostly C units. Medium-sized fibers (dp = 1.5-4 microns) included regular, intermediate, and irregular D units, as well as C units. Thin fibers (dp < or = 1.5 microns) were defined as B units.(ABSTRACT TRUNCATED AT 400 WORDS)
Thiol-Group Binding of Zinc to a β-Lactamase of <i>Bacillus cereus:</i> Differential Effects on Enzyme Activity with Penicillin and Cephalosporins as Substrates (1968)

Zinc, which is required for the hydrolysis of cephalosporins by a crude enzyme from Bacillus cereus 569, also increased the stability of this activity during storage. A loss in activity of the zinc-activated enzyme which occurred on prolonged hydrolysis of cephalosporin C was not restored by further addition of zinc. The thiol reagents N-ethyl maleimide (NEM), iodoacetic acid (IAA), CdCl(2), and p-chloromercuribenzoate, all at 10(-3)m, and iodine at 1.6 x 10(-3)n prevent zinc activation of the "cephalosporinase" activity. However, NEM and IAA have minimal or no demonstrable inhibitory effect if the enzyme is first treated with zinc. This suggests that zinc is linked to the apoenzyme by a thiol group. Activation by zinc is only partially prevented by NEM if the crude enzyme is pretreated with nickel, which alone causes negligible activation of the apoenzyme. The order of affinities of these metals for the apparent thiol group is thus Hg(++), Cd(++) > Zn(++) > Ni(++). The "cephalosporinase" inhibition by Hg(++) was reversible with dithiothreitol. These metals and thiol reagents do not decrease the ability of the crude enzyme to hydrolyze benzylpenicillin, which is consistent with the report that purified "penicillinase" from B. cereus contains no cysteine residue. This suggests that the beta-lactamases of B. cereus that hydrolyze penicillin and cephalosporins differ from each other by at least one amino acid (cysteine).
Effects of viscosity in a partially ionized channel flow with thermionic emission (2009)

The flow of the partially ionized gas inside thermionic hollow cathodes spans a diverse range of theoretical disciplines in plasma physics and fluid mechanics. Understanding and predicting the evolution of such flows has many practical implications because hollow cathodes are critical components of electric propulsion systems used onboard scientific and commercial spacecraft presently in space or in the mission planning stages. As space missions become more demanding of the propulsion system in terms of throughput, understanding and predicting failure mechanisms of the system becomes imperative. Two-dimensional numerical simulations of the partially ionized gas generated by a thermionic hollow cathode have been performed to quantify the effects of viscosity inside the cylindrical channel of the device. A comparison of the inviscid and fully viscous flow fields shows that viscosity has a significant impact on the atomic species and a lesser effect on the ions. The internal pressure is determined to be more than 40% higher compared to the inviscid solution and the Reynolds number for the flow of atoms is found to be less than 20 inside the channel. Although the Mach number is computed to be &lt;0.1 for approximately 95% of the channel, the solution for the velocity flow field begins to deviate from the Poiseuille (parabolic) solution at about 50% of the channel due mainly to collisional drag with ions.
Muscarinic Cholinergic Binding in Rat Brain (1974)

Binding sites with high affinity and specificity for [(3)H]quinuclidinyl benzilate (QNB) are present in homogenates of rat brain. The characteristics of the binding sites resemble those of muscarinic cholinergic receptors. Specific binding is saturable with respect to [(3)H]QNB and tissue concentration and is time-, temperature-, and pH-dependent. The bimolecular rate of association (2.0 x 10(8) M(-1) min(-1)) and dissociation (1.2 x 10(-2) min(-1)) at 35 degrees indicate a dissociation constant of 60 pM and a density of 65 pmol/g of brain. Muscarinic antagonists and agonists displace specific [(3)H]QNB binding, while nicotinic and non-cholinergic drugs possess little affinity for [(3)H]QNB-binding sites.
Continuous Silica Coatings on Glass Fibers via Bioinspired Approaches (2007)

Simple methods for producing continuous inorganic coatings on fibers have application in multiple technologies. The application of bioinspired strategies for the formation of particulate inorganic materials has been widely investigated and provides routes to inorganic materials under environmentally benign conditions. In this work, we describe the formation of stable and continuous inorganic coatings on glass fibers via the polymerization of silica in the presence of biopolymers. The formation of both organic and inorganic coatings was investigated via X-ray photoelectron spectroscopy, attenuated total reflection Fourier transform infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray analysis. The simple route to silica coatings presented herein could be interesting for the development of functional hybrid fibrous materials suitable for catalytic and sensor applications, given the homogeneous nature of the silica films and the benign conditions employed for film formation.
Joint Channel Estimation and Synchronization for MIMO–OFDM in the Presence of Carrier and Sampling Frequency Offsets (2008)

A pilot-aided scheme is proposed for the joint estimation and tracking of channel impulse response (CIR), carrier frequency offset (CFO) and sampling frequency offset (SFO) in burst mode, multiple-input-multiple-output (MIMO), and orthogonal frequency division multiplexing(OFDM) systems. First, a received signal model that takes into account nonlinear CFO/SFO effects is formulated. Then, based on the derived signal model and the received multicarrier signal samples containing the pilot tones in the frequency domain, an objective function that includes MIMO CIR, CFO, and SFO is introduced to develop a vector recursive-least-square (RLS)-based joint channel estimation and synchronization algorithm. The analysis and simulation results show that, over the large ranges of the CFO and SFO values, the proposed estimation and tracking scheme offers fast convergence, high stability, and a near-optimum receiver performance that is remarkably close to the ideal performance in the case of perfect channel estimation and synchronization over quasi-static Rayleigh multipath fading channels.
Coherent combining of low-peak-power pulsed fiber amplifiers with 80-ns pulse duration (2011)

We investigate the feasibility of pulsed fiber amplifier coherent combining. Therefore, we characterize phase fluctuations in low-peak-power pulsed fiber amplifiers using two different interferometric techniques. These measurements reveal that for low peak-powers, phase fluctuations remain moderate during the pulses. Noticeable phase fluctuations occurring between the pulses can be perfectly controlled using classical continuous-wave-efficient combining techniques. Results of such realization combining two low-peak-power pulsed fiber amplifiers, using classical frequency-tagging coherent combining techniques, are presented. Phase difference measurement is performed between pulses using a small signal leak from the common master oscillator. For the first time to our knowledge, successful coherent combining of two low-peak- power pulsed fiber amplifiers is thereby demonstrated.
Structure−Activity Relationships of Small Phosphopeptides, Inhibitors of Grb2 SH2 Domain, and Their Prodrugs (2004)

To develop potential antitumor agents directed toward HER2/ErbB2 overexpression in cancer, we have designed inhibitors of the recognition between the phosphotyrosine of the receptor and the SH2 domain of the adaptor protein Grb2. In the first part of the paper, we report the synthesis of mimetics of the constrained (alpha-Me)phosphotyrosine residue such as (alpha-Me)-4-phosphonomethylphenylalanine (-CH2PO3H2), (alpha-Me) 4-phosphonodifluoromethylphenylalanine (-CF2PO3H2), and (alpha-Me)-4-phosphonophenylalanine (-PO3H2). The incorporation of these residues in the mAZ-pTyr-Xaa-Asn-NH2 series provided compounds with very high affinity for the Grb2 SH2 domain, in the 10(-8)-10(-9) range of Kd values. These compounds behave as potent antagonists of the Grb2-Shc interaction. Our results highlight the importance of the doubly negative charge borne by the pY + 1 amino acid in accordance with the interactions observed in the complex crystallized between mAZ-pTyr-(alphaMe)pTyr-Asn-NH2 and the Grb2 SH2 domain. mAZ-pTyr-(alphaMe)pTyr-Asn-NH2 was derivatized as the S-acetyl thioester (SATE) of the phosphotyrosine residues, and its surrogates provided prodrugs with very potent antiproliferative activity on cells overexpressing HER2/ErbB2, with ED50 values amounting to 0.1 microM. Finally a new prodrug is put forth under the form of a monobenzyl ester of phosphate group that is as active as and much easier to synthesize than SATE prodrugs. These compounds show promising activity for further testing on in vivo models.
New method of multi-level optimization (2010)

The method for multi-level optimization is suggested. The method is based on specific approach to multi-level optimization according which the system should be optimized is sequential levels using relevant optimization criteria. The final solution of the multi-level optimization task is that passed through all levels of optimization.
An Analytical Solution to Single Scattering in Homogeneous Participating Media (2009)

Abstract Despite their numerous applications, efficiently rendering participating media remains a challenging task due to the intricacy of the radiative transport equation. As they provide a generic means of solving a wide variety of problems, numerical methods are most often used to solve the air‐light integral even under simplifying assumptions. In this paper, we present a novel analytical approach to single scattering from isotropic point light sources in homogeneous media. We derive the first closed‐form solution to the air‐light integral in isotropic media and extend this formulation to anisotropic phase functions. The technique relies neither on pre‐computation nor on storage, and we provide a practical implementation allowing for an explicit control on the accuracy of the solutions. Finally, we demonstrate its quantitative and qualitative benefits over both previous numerical and analytical approaches.
Field Monitoring of Roller Vibration during Compaction of Subgrade Soil (2007)

A field investigation was carried out with an instrumented vibratory roller compactor to explore the relationship between vibration characteristics and underlying soil properties, namely soil stiffness. The roller was outfitted with instrumentation to monitor drum and frame acceleration, as well as eccentric excitation force. Multiple consecutive passes were performed over six test beds on an active earthwork construction site to capture changes in roller vibration during compaction. Using lumped parameter vibration theory, soil stiffness was extracted from the roller data (drum and frame acceleration and drum phase lag). Both drum acceleration and drum phase lag were found to be very sensitive to changes in underlying soil stiffness. The drum–soil natural frequency of the coupled roller–soil system varied considerably and increased with compaction-induced soil stiffening. Phase lag always decreased with increasing soil stiffness, whereas drum acceleration trends depended on whether the excitation frequency was less than or greater than resonance. Roller-determined soil stiffness was found to be a function of the eccentric force, and heterogeneity in moisture, lift thickness, and underlying stiffness has a considerable affect on roller vibration behavior. When used as a proof roller, the instrumented roller identified soft areas in the embankment that were not identified by a static proof roll test.
Phase‐Scrambled RF Excitation for 3D Volume‐Selective Multislice NMR Imaging (1992)

An RF excitation technique with which one can improve the effective dynamic range of the receiver and reduce the interference between slices for 3D volume-selective multislice MRI is described. The basic idea of the technique is to use phase scrambling in conjunction with slice encoding through the use of RF pulses. The spins in each slice are encoded by RF pulses which have the scrambled as well as slice-encoded phase components along the slice-selection direction. The scrambled, or randomly distributed, phase reduces the peak signal intensity, thereby reducing the dynamic range of the signal. Since the proposed technique utilizes RF slice encoding together with phase scrambling, interslice image interference is greatly reduced and the dynamic range is improved. In addition, the method has several advantages such as a reduction in the power requirement for the RF pulses and the elimination of the necessity for hardware such as nonlinear gradient coils.
Superhydrophobic surfaces with fluorinated cellulose nanofiber assemblies for oil–water separation (2017)

Fluorinated cellulose nanofiber assemblies exhibit high oil–water separation efficiency and recyclability (at least 50 times) for practical applications.
RR-ALOHA, a Reliable R-ALOHA broadcast channel for ad-hoc inter-vehicle communication networks (2002)

Ad-hoc networking is under evaluation for\ninter-vehicle communication architectures. In spite of\nthe large existing literature, many problems generated\nby the peculiarity of this specific scenario are still unsolved.\nIn this paper we present a novel MAC protocol,\nRR-ALOHA, able to guarantee a reliable single-hop\nbroadcast communication in an ad-hoc network environment\nwhere the hidden terminals problem exists. This\nprotocol is designed for the inter-vehicle communication\narchitecture based on UTRA-TDD slotted physical channel,\nbut can be easily modified to operate on other standard\nphysical layers. According to this protocol any active\nterminal can reserve a channel by capturing a slot in\nthe frame. Reliable communication is guaranteed, after\naccess, even in presence of hidden terminals thanks to the\ninformation exchanged by the active terminals. The operation\nof the protocol is completely distributed and enables\nalso to install channels of different speeds to satisfy QoS of\ndifferent services. The protocol feasibility and some basic\nperformance figures are discussed to prove the effectiveness\nof the protocol itself in the inter-vehicle communication\nscenario.
CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies (2020)

CD123, the α chain of the interleukin 3 receptor, is a cytokine receptor that is overexpressed in multiple hematolymphoid neoplasms, including acute myeloid leukemia, blastic plasmacytoid dendritic cell neoplasm, acute lymphoblastic leukemia, hairy cell leukemia, and systemic mastocytosis. Importantly, CD123 expression is upregulated in leukemic stem cells relative to non-neoplastic hematopoietic stem cells, which makes it a useful diagnostic and therapeutic biomarker in hematologic malignancies. Varying levels of evidence have shown that CD123-targeted therapy represents a promising therapeutic approach in several cancers. Tagraxofusp, an anti-CD123 antibody conjugated to a diphtheria toxin, has been approved for use in patients with blastic plasmacytoid dendritic cell neoplasm. Multiple clinical trials are investigating the use of various CD123-targeting agents, including chimeric antigen receptor-modified T cells (expressing CD123, monoclonal antibodies, combined CD3-CD123 dual-affinity retargeting antibody therapy, recombinant fusion proteins, and CD123-engager T cells. In this review, we provide an overview of laboratory techniques used to evaluate and monitor CD123 expression, describe the strengths and limitations of detecting this biomarker in guiding therapy decisions, and provide an overview of the pharmacologic principles and strategies used in CD123-targeted therapies.
The calmodulin binding domain of nitric oxide synthase and adenylyl cyclase (1993)

Peptides corresponding to regions of the calmodulin-activated NO-synthase and of the calmodulin dependent adenylyl cyclase, which could represent the calmodulin binding domains of the two proteins, have been synthesized and tested for calmodulin binding. The chosen peptides were those in the sequence of the two proteins which most closely corresponded to the accepted general properties of the calmodulin binding domains, i.e., a hydrophobic sequence containing basic amino acids. In the case of the NO-synthase, the putative high-affinity calmodulin binding domain was identified by urea gel electrophoresis and fluorescence spectroscopy with dansylcalmodulin as peptide NO-30 (amino acids 725-754). The highest affinity calmodulin binding site of the calmodulin-dependent adenylyl cyclase was assigned to peptide AC-28 (amino acids 495-522) by titration with dansylcalmodulin and by the ability to inhibit the calmodulin-stimulated activity of purified calmodulin-stimulated adenylyl cyclase. The sequence 495-522 is located in the unit protruding into the cytosol from the sixth putative transmembrane domain of the molecule. It has the typical hydrophobic/basic composition of canonical calmodulin binding domains, and also contains, like most calmodulin binding domains, an aromatic amino acid in its N-terminal portion. It also contains two Cys residues in the central portion, which is an unusual feature of the calmodulin binding domain of this enzyme.
Assessment of anti-amyloidogenic activity of marine red alga<i>G. acerosa</i>against Alzheimer’s beta-amyloid peptide 25–35 (2014)

Overall, the results suggest that G. acerosa might have direct interaction with the aggregated peptide, thereby preventing oligomerization and fibrillation of Aβ 25-35.
An Evaluation of a STEM Program for Middle School Students on Learning Disability Related IEPs (2008)

A year long Science, Technology, Engineering and Math (STEM) program was developed for middle schools students on Individualized Education Programs (IEPs) involving learning disabilities. The workshops were designed to encourage students both on IEPs and not on IEPs to explore STEM as a future career choice by building their knowledge and confidence. The participants in the workshops included 11 students on IEPs and 15 students not on IEPs. Parents also provided feedback regarding their attitudes toward the program. The results indicated that there were increases in student participant knowledge and career interest for both the students not on IEPs and the students on IEPs. Overall, reactions to the program from both students and parents were quite positive.
El cuento del fortachón en el folklore y la literatura (2006)

El motivo del hombre de fuerza descomunal ha obtenido amplia acogida en el folklore de todo el mundo. Aqui se comentan los Tipos folkloricos (de acuerdo a Aarne-Thompson-Uther) protagonizados por tal personaje, y la evolucion que experimenta de hombre fuerte a redomado picaro, capaz de vencer con la astucia y no con la fuerza.
Mathematical modelling and analysis of the pyrosequencing reaction system (2005)

The Pyrosequencing(TM) technology is a newly developed DNA sequencing method that monitors DNA nucleotide incorporation in real-time. A set of coupled enzymatic reactions, together with bioluminescence, detects incorporated nucleotides in the form of light pulses, yielding a characteristic light profile. In this study, a biochemical model of the Pyrosequencing reaction system is suggested and implemented. The model is constructed utilizing an assumption of irreversible Michaelis-Menten rate equations and a constant incorporation efficiency. The kinetic parameters are studied and values are chosen to obtain as reliable simulation results as possible. The results presented here show strong resemblance with real experiments. The model is able to capture the dynamics of a single light pulse with great accuracy, as well as the overall characteristics of a whole pyrogram(TM). The plus- and minus-shift effects observed in experiments are successfully reconstructed by two constant efficiency factors. Furthermore, pulse broadening can partly be explained by apyrase inhibition and successive dilution.
Power invariant vector compaction based on bit clustering and temporal partitioning (1998)

Power dissipation in digital circuits is strongly pattern dependent. Thus, to derive accurate simulation-based power estimates, a large amount of input vectors is usually required. This paper proposes a vector compaction technique aiming at providing accurate power figures in a shorter simulation time for complex sequential circuits characterized by some hundreds of inputs. From pair-wise spatio-temporal signal correlations, the proposed approach is based on bit clustering and temporal partitioning of the input stream aiming at preserving the statistical properties of the original stream and maintaining the typical switching behavior of the circuit. The effectiveness of the proposed approach has been demonstrated over a significant set of industrial case studies implemented in CMOS submicron technology. While achieving a 10x to 50x stream size reduction, the reported results show an average and maximum errors of 2.4% and 7.1% respectively, over the simulation-based power estimates derived from the original input stream.