gebhart/patrepeval huggingface dataset:
FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells (1999)

Protein-tyrosine kinases p56(Lck), SYK, and ZAP-70 and downstream adaptors LAT and SLP-76 have been implicated as essential components in T-cell activation. Another lymphoid-specific adaptor FYB/SLAP has also been identified as a predominant binding partner of SLP-76 and the Src kinase FYN-T, although its role in the activation process has been unclear. In this study, we demonstrate that FYN-T selectively phosphorylates FYB providing a template for the recruitment of FYN-T and SLP-76 SH2 domain binding. This interaction is unusual in its distinct cytoplasmic localization and its long term stable kinetics of phosphorylation. Furthermore, we demonstrate for the first time that the co-expression of all three components of the FYN-T-FYB-SLP-76 matrix can synergistically up-regulate T-cell receptor-driven interleukin 2 transcription activity. These findings document the existence of a T-cell receptor-regulated FYN-T-FYB pathway that interfaces with the adaptor SLP-76 and up-regulates lymphokine production in T-cells.
Transcriptional analysis of the major surface array gene of Caulobacter crescentus (1988)

The major component of the paracrystalline surface array of Caulobacter crescentus CB15 and one of the most abundant cellular proteins is a protein designated 130K. We have determined the DNA sequence of the 5' portion of the 130K gene, including the N-terminal one-third of the protein coding region, and analyzed the transcription of the gene. The site of transcription initiation was determined by S1 mapping of Caulobacter RNA. Although the DNA sequence upstream from the transcription start site showed significant homology to the consensus promoter sequences of Escherichia coli, S1 analysis of RNA from E. coli carrying the 130K gene on a plasmid indicated that the 130K promoter was not transcribed by E. coli RNA polymerase in vivo. Quantitative S1 analysis of RNA isolated from synchronously growing Caulobacter cells suggested that this promoter was not under developmental regulation; the amount of 130K transcript varied no more than 1.5-fold during the cell cycle. The length of the 130K mRNA was determined to be 3.3 kilobases by Northern (RNA blot) analysis, indicating that the 130K mRNA is not part of a polycistron. The amino acid sequence predicted from the DNA sequence agreed well with the N-terminal amino acid sequence determined by sequencing of the 130K protein. The 130K protein appears to be synthesized without an N-terminal leader sequence, but the N-terminal 20 amino acids are relatively hydrophobic and may function like a signal sequence during transmembrane translocation.
New thermoelectric components using microsystem technologies (2004)

This work describes the first thermoelectric devices based on the V-VI-compounds Bi/sub 2/Te/sub 3/ and (Bi,Sb)/sub 2/Te/sub 3/ which can be manufactured by means of regular thin film technology in combination with microsystem technology. Fabrication concept, material deposition for some 10-μm-thick layers and the properties of the deposited thermoelectric materials will be reported. First device properties for Peltier-coolers and thermogenerators will be shown as well as investigations on long term and cycling stability. Data on metal/semiconductor contact resistance were extracted form device data. Device characteristics like response time for a Peltier-cooler and power output for a thermogenerator will be compared to commercial devices.
Analyzing goal semantics for rights, permissions, and obligations (2005)

Software requirements, rights, permissions, obligations, and operations of policy enforcing systems are often misaligned. Our goal is to develop tools and techniques that help requirements engineers and policy makers bring policies and system requirements into better alignment. Goals from requirements engineering are useful for distilling natural language policy statements into structured descriptions of these interactions; however, they are limited in that they are not easy to compare with one another despite sharing common semantic features. In this paper, we describe a process called semantic parameterization that we use to derive semantic models from goals mined from privacy policy documents. We present example semantic models that enable comparing policy statements and present a template method for generating natural language policy statements (and ultimately requirements) from unique semantic models. The semantic models are described by a context-free grammar called KTL that has been validated within the context of the most frequently expressed goals in over 100 Internet privacy policy documents. KTL is supported by a policy analysis tool that supports queries and policy statement generation.
Bone regeneration of dental implant dehiscence defects using a cultured periosteum membrane (2008)

This study demonstrated the feasibility of a CP membrane to regenerate bone at implant dehiscence defect.
Optical Limiting In Solutions Of Metallo-Phthalocyanines And Naphthalocyanines (1989)

Optical limiting measurements have been made on solutions of several metal containing phthalocyanines and naphthalocyanines. Measurements at 532nm using nanosecond pulses from a Q-switched Nd:YAG laser show limiting throughputs of 1-10 millijoules with mild focussing in alcohol solutions with nominal transmissions of 30-70%. Measurements on chloro-aluminum-phthalocyanine solutions utilizing individual 30 psec pulses or trains (spanning about 100nsec) of modelocked pulses have shown even lower limiting throughputs. Thus, the dynamic range of the limiting behavior has been shown to cover at least three orders of magnitude. Prompt limiting is attributed to strong singlet-singlet (S1-Sn) absorption, whereas the longer time limiting behavior is postulated to result from strong triplet-triplet (T1-Tn) absorption. In addition to these studies, efforts have been underway to identify materials with reduced limiting throughput and improved optical transmission characteristics.
The Double Jeopardy Phenomenon and the Mediating Effect of Brand Penetration between Advertising and Brand Loyalty (2005)

<h3>ABSTRACT</h3> In a study of the Double Jeopardy (DJ) phenomenon and the mediating effect of brand penetration between advertising and brand loyalty, we integrate a survey of 19,335 consumers on their buying behavior of 187 brands across two fast moving consumer goods categories, shampoo and detergent, and a database of advertising expenditures on these brands in four major cities in China. We find that (1) smaller brands are punished twice for being small, following the well-known DJ pattern, which says that brands with larger market penetration tend to enjoy higher repeated purchases and smaller brands attract fewer buyers who also buy less; (2) brand penetration plays a mediating role in the relationship between advertising and brand loyalty; and (3) there is an asymmetric effect of market penetration on brand loyalty for small and big brands.
Characterization of SUN-domain proteins at the higher plant nuclear envelope (2009)

Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton, and have been shown to be conserved in non-plant systems. In this paper, we report the presence of members of this family in the plant kingdom, and investigate the two Arabidopsis SUN-domain proteins, AtSUN1 and AtSUN2. Our results indicate they contain the highly conserved C-terminal SUN domain, and share similar structural features with animal and fungal SUN-domain proteins including a functional coiled-coil domain and nuclear localization signal. Both are expressed in various tissues with AtSUN2 expression levels relatively low but upregulated in proliferating tissues. Further, we found AtSUN1 and AtSUN2 expressed as fluorescent protein fusions, to localize to and show low mobility in the nuclear envelope (NE), particularly in the INM. Deletion of various functional domains including the N terminus and coiled-coil domain affect the localization and increase the mobility of AtSUN1 and AtSUN2. Finally, we present evidence that AtSUN1 and AtSUN2 are present as homomers and heteromers in vivo, and that the coiled-coil domains are required for this. The study provides evidence suggesting the existence of cytoskeletal-nucleoskeletal bridging complexes at the plant NE.
Thickness dependent dielectric properties of Sol-gel prepared lead lanthanum titanate films (1995)

Abstract A series of lead-lanthanum-titanate films (PLT, Pb0.65La0.28Ti0.96O3) films of differing thickness were prepared on Pt/Ti/SiO2/Si substrates using sol-gel techniques. One to six layer films with a layer thickness of 330 Å/layer were deposited by spin-coating from a partially hydrolyzed metal alkoxide solution. After each layer was applied, the films were annealed using rapid thermal annealing (150°C/sec temperature ramp, 1 minute at 700°C, O2 atmosphere). The films were characterized by X-ray diffraction (XRD), electrical measurement of dielectric constant, dissipation factor and leakage current, and cross-sectional transmission electron microscopy (TEM). For all films, only the perovskite phase of PLT was observed by both XRD and TEM. The films showed a strong [100] orientation on the [111] textured Pt substrates. Electrical measurements determined the dielectric constant at 200 kHz for films 1000 Å thick and thicker to be ∼550. These films had leakage current densities of less than 1×10−7 amp/cm2 at 1 volt. The 1000 Å film has an equivalent oxide thickness of 7.2 Å and a capacitance per unit area of 48 fF/μm2. Films less than 1000 Å thick showed reduced dielectric constants and greatly increased leakage currents. The possible origins for the degradation in electrical properties of very thin films (stress, poorly crystallized interfacial layers, second phases, and electrode interactions) were evaluated using TEM.
Detection of soluble class i molecules (non hla‐a or hla‐b) in serum, spleen membranes and lymphocytes in culture (1989)

Soluble major histocompatibility complex class I molecules (sHLA) present in human serum can be resolved by gel filtration into two different peaks with an apparent molecular mass of about 200 kDa (30% of the total) and 50-60 kDa (60%-70%). The serological analysis of the peaks shows that A or B specificities can only be detected in the 200 kDa peak while both are recognized by the monomorphic W6/32 monoclonal antibody (mAb) and anti-beta 2-microglobulin mAb. Such sHLA (non HLA-A or -B) molecules are released from human spleen membranes upon incubation at 37 degrees C and have been purified by affinity chromatography with mAb W6/32 bound to Sepharose. The molecular mass analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the sHLA (non HLA-A or -B) and of the classical HLA-A or -B antigens still bound to the membranes and purified from the same membranes after detergent solubilization does not show a significant difference, indicating that sHLA do not represent proteolytic fragments of the classical HLA-A or -B antigens. The presence of sHLA (non HLA-A or -B) has also been detected in the supernatants of lymphocyte cultures and increases dramatically upon stimulation by mitogens. The effect of pokeweed mitogen, phytohemagglutinin, Staphylococcus aureus Cowan strain and phorbol 12-myristate 13-acetate on the secretion of sHLA has been studied. The molecular mass of the secreted sHLA (detected using [14C]leucine) is compared with the classical transmembrane proteins.
Nondepleting Anti-CD40-Based Therapy Prolongs Allograft Survival in Nonhuman Primates (2011)

Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has largely depended on mAbs directed against CD154, limiting the potential for translation due to its association with thromboembolic events. Though targeting CD40 as an alternative to CD154 has been successful at preventing allograft rejection in preclinical models, there have been no reports on the effects of CD40-specific agents in human transplant recipients. This delay in clinical translation may in part be explained by the presence of cellular depletion with many CD40-specific mAbs. As such, the optimal biologic properties of CD40-directed immunotherapy remain to be determined. In this report, we have characterized 3A8, a human CD40-specific mAb and evaluated its efficacy in a rhesus macaque model of islet cell transplantation. Despite partially agonistic properties and the inability to block CD40 binding of soluble CD154 (sCD154) in vitro, 3A8-based therapy markedly prolonged islet allograft survival without depleting B cells. Our results indicate that the allograft-protective effects of CD40-directed costimulation blockade do not require sCD154 blockade, complete antagonism or cellular depletion, and serve to support and guide the continued development of CD40-specific agents for clinical translation.
Bleed fastness of fluorescent whitening agents in mass whitened paper. (1975)

Paper samples mass whitened with fluorescent whiteing agents (FWAs) of three different types (di-, tetra-, and hexasulfonated derivatives of 4,4'-diaminostilbene-2,2'-disulfonic acid) were examined for bleed fastness in five different eluents. Fluorescece intensity was measured by a sensitive spectrofluorimetric technique instead of the usual visual assessment. The degree of bleed obtained from each of the FWAs tested was less than 0.4mg/600 cm2 of paper surface area. The FWAs were applied at a normal concentration of use i.e. 0.05% active substance. FWAs with a high degree of sulfonation tend to bleed in aqueous solvents, and those with a lower degree of sulfonation in alcohol solutions. In aqueous acid solutions the degree of bleed was very low in all cases (0.04 mg/600 cm2 of paper surface area). In fatty solutions there was no bleed at all. The limit of detection was 3mug/600 cm2 of paper surface area, with an accuracy of +/-15%.
Improved close-in detection for the mine hunter/killer system (2001)

The Close-In Detector (CID) is the vehicle-mounted multi-sensor anti-tank landmine detection technology for the Army CECOM Night Vision Electronic Sensors Directorate (NVESD) Mine Hunter-Killer (MH/K) Program. The CID includes two down-looking sensor arrays: a 20-antenna ground-penetrating radar (GPR) and a 16-coil metal detector (MD). These arrays span 3-meters in front of a high mobility, multipurpose wheeled vehicle (HMMWV). The CID also includes a roof-mounted, forward looking infrared (FLIR) camera that images a trapezoidal area of the road ahead of the vehicle. Signals from each of the three sensors are processed separately to detect and localize objects of interest. Features of candidate objects are integrated in a processor that uses them to discriminates between anti-tank (AT) mines and clutter and produces a list of suspected mine locations which are passed to the neutralization subsystem of MH/K. This paper reviews the current design and performance of the CID based on field test results on dirt and gravel mine test lanes. Improvements in CID performance for probability of detection, false alarm rate, target positional accuracy and system rate of advance over the past year and a half that meet most of the program goals are described. Sensor performances are compared, and the effectiveness of six different sensor fusion approaches are measured and compared.
Production of Sophorolipid Biosurfactant by<i>Pichia anomala</i> (2008)

Biosurfactant production by Pichia anomala PY1, a thermotorelant strain isolated from fermented food, was examined as grown in media containing various carbon and nitrogen sources. The optimal conditions for biosurfactant production included 4% soybean oil as carbon source at pH 5.5 at 30 C for 7 d. Under these conditions, the surface tension of the medium decreased to 28 mN/m with oil displacement measured at 69.43 cm 2 . Comparative studies of biosurfactant production in media containing glucose or soybean oil were performed. The biosurfactants obtained were isolated and purified by chromatographic methods. The molecular weights of samples were further investigated by mass spectrometry. In medium containing glucose, biosurfactants of molecular weights of 675, 691, and 707 were obtained, while those isolated from medium containing soybean oil were of molecular weights of 658, 675, and 691. These results reveal that sophorolipid compounds containing fatty acids of C20 and C18:1 were produced from both media.
Synthesis of Carbamic Esters Derivatives of Itols:  Antifungal Activity against Various Crop Diseases (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of Carbamic Esters Derivatives of Itols: Antifungal Activity against Various Crop DiseasesChristophe Len, Denis Postel, Gino Ronco, Pierre Villa, Christel Goubert, Eric Jeufrault, Bernard Mathon, and Hervé SimonView Author Information Laboratoire de Chimie Organique et Cinétique, Université de Picardie-Jules Verne, 80039 Amiens, France Service Régional de la Protection des Végétaux, 80000 Amiens, FranceCite this: J. Agric. Food Chem. 1997, 45, 1, 3–6Publication Date (Web):January 20, 1997Publication History Received30 September 1996Published online20 January 1997Published inissue 1 January 1997https://pubs.acs.org/doi/10.1021/jf9607371https://doi.org/10.1021/jf9607371rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views398Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Antifungal activity,Antimicrobial agents,Inhibition,Organic compounds Get e-Alerts
Scaling behavior of a model of block copolymers in three dimensions (1991)

We have studied the dynamical and equilibrium scaling behaviors of a coarse-grained model for microphase separation of block copolymers. Our numerical study has been carried out in three dimensions. We compute the power-law exponent \ensuremath{\theta} characterizing the equilibrium microdomain size ${\mathit{R}}_{\mathrm{eq}}$ as a function of the molecular weight of the copolymers N as ${\mathit{R}}_{\mathrm{eq}}$\ensuremath{\sim}${\mathit{N}}^{\mathrm{\ensuremath{\theta}}}$, and conclude that we are able to study the weak-segregation regime, but not the true strong-segregation regime of the model. We have also tested scaling hypotheses connecting the microdomain size and the equilibrium structure factor of the block copolymers.
1‐[(2‐Arylthiazol‐4‐yl)methyl]azoles as a New Class of Anticonvulsants: Design, Synthesis,<i>In vivo</i>Screening, and<i>In silico</i>Drug‐like Properties (2011)

A series of novel thiazole incorporated (arylalkyl)azoles were synthesized and screened for their anticonvulsant properties using maximal electroshock and pentylenetetrazole models in mice. Among target compounds, 1-[(2-(4-chlorophenyl)thiazol-4-yl)methyl]-1H-imidazole (compound 4b), 1-[(2-phenylthiazol-4-yl)methyl]-1H-1,2,4-tria-zole (8a), and its 4-chlorophenyl analog (compound 8b) were able to display noticeable anticonvulsant activity in both pentylenetetrazole and maximal electroshock tests with percentage protection range of 33-100%. A computational study was carried out for prediction of pharmacokinetics properties and drug-likeness. The structure-activity relationship and in silico drug relevant properties (molecular weight, topological polar surface area, clog P, hydrogen bond donors, hydrogen bond acceptors, and log BB) confirmed that the compounds were within the range set by Lipinski's rule-of-five, and possessing favorable physicochemical properties for acting as CNS-drugs, making them potentially promising agents for epilepsy therapy.
Preparation and adsorption properties of polyethylenimine containing fibrous adsorbent for carbon dioxide capture (2008)

Abstract We successfully prepared a novel fibrous adsorbent for carbon dioxide (CO 2 ) capture by coating polyethylenimine (PEI) on a glass fiber matrix, using epoxy resin (EP) as crosslinking agent. The physicochemical properties of the fibrous adsorbents were characterized in terms of Fourier transform infrared spectrometry and thermogravimetric analysis. Factors that affected the adsorption capacity of the fibrous adsorbent were studied, including the crosslinking agent dosage, coating weight, moisture, adsorption temperature, and CO 2 concentration of the simulated flue gas. The experimental results indicate that the properly crosslinked fibrous adsorbent had a high thermal stability at about 280°C. With a PEI/EP ratio of 10:1, a maximum adsorption capacity of 276.96 mg of CO 2 /g of PEI was obtained at 30°C. Moisture had a promoting influence on the adsorption of CO 2 from flue gas. The CO 2 adsorption capacity of the fibrous adsorbent in the presence of moisture could be 19 times higher than that in dry conditions. The fibrous adsorbent could be completely regenerated at 120°C. The CO 2 adsorption capacity of the regenerated fibrous adsorbent was almost the same as that of the fresh adsorbent. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Optische Übertragungstechnik mit Lichtwellenleitern (1993)

Die LWL-Technik hat heute größte Bedeutung im nachrichtentechnischen Bereich gewonnen, wo sie in naher Zukunft bald alle Koaxialkabel verdrängen wird. Maßgebend hierfür sind folgende einzigartige Eigenschaften:
Down‐regulation of <i>drs</i> mRNA in Colorectal Neoplasms (2002)

The drs gene was originally isolated as a transformation suppressor gene against the v-src oncogene. Expression of drs mRNA is down-regulated by retroviral oncogenes such as v-src and v-K-ras in the rat cell line F2408. Expression of drs mRNA is also markedly reduced in a variety of human cancer cell lines, including those of carcinomas of the colon, bladder, and ovary, suggesting that down-regulation of drs mRNA is correlated with the development of human cancers. To clarify the correlation between down-regulation of the drs gene and malignant tumor formation in human colorectal neoplasms, we examined expression of drs mRNA in a variety of colon cancer tissues by in situ hybridization. A total of 53 morphologically distinct neoplastic specimens were divided into the following five groups according to morphology: low and high grade adenoma in 7 and 12 cases, respectively (groups A, B), protruded-type carcinoma in 16 (group C), superficial-type carcinoma with an adenomatous component in 10 (group D) or superficial-type carcinomas without any adenomatous component in 8 (group E). Expression of drs mRNA was detected in normal mucosa, low-grade adenoma and most superficial-type carcinomas without any adenomatous component. On the other hand, the rate of drs mRNA expression was significantly lower in protruded-type adenocarcinoma and superficial-type carcinoma with an adenomatous component. Our results indicate that down-regulation of drs mRNA is closely correlated with carcinomas which arise from adenomatous polyps in the course of the adenoma-carcinoma sequence, but that most carcinomas arising de novo are independent of the tumor suppressor function of the drs gene.