gebhart/patrepeval huggingface dataset:
Aspartyl Protease Inhibitor Pepstatin Binds to the Presenilins of Alzheimer's Disease (2001)

Mutations in the presenilin genes PS1 and PS2 cause early-onset Alzheimer's disease by altering gamma-secretase cleavage of the amyloid precursor protein, the last step in the generation of Abeta peptide. Ablation of presenilin (PS) genes, or mutation of two critical aspartates, abolishes gamma-secretase cleavage, suggesting that PS may be the gamma-secretases. Independently, inhibition experiments indicate that gamma-secretase is an aspartyl protease. To characterize the putative gamma-secretase activity associated with presenilins, lysates from human neuroblastoma SH-SY5Y and human brain homogenates were incubated with biotin derivatives of pepstatin, followed by immunoprecipitation of PS and associated proteins, and biotin detection by Western blotting. Precipitation with PS1 antibodies, directed to either N-terminal or loop regions, yielded the same 43 kDa band, of apparent molecular mass consistent with that of full-length PS1, although it may represent an aspartyl protease complexed with PS1. Incubation of cell lysates with pepstatin-biotin, followed by streptavidin precipitation and PS1 Western blotting, revealed PS1 fragments and full-length protein, indicating that pepstatin-biotin bound to both cleaved and uncleaved PS1. Binding could be competed by gamma-secretase inhibitor L-685,458 and could not be achieved with a PS1 mutant lacking the two transmembrane aspartates. Pepstatin-biotin was also shown to bind to PS2. PS1 was specifically absorbed to pepstatin-agarose, with an optimal pH of 6. Binding of pepstatin-biotin to PS1 from lymphocytes of a heterozygous carrier of pathologic exon 9 deletion was markedly decreased as compared to control lymphocytes, suggesting that this PS1 mutation altered the pepstatin binding site.
Review on protection coordination strategies and development of an effective protection coordination system for DC microgrid (2014)

In this paper, common DC-fault detection methods have been reviewed. Effects of two line-to-line and line-to-ground fault types from various fault locations to operation of the DC system are presented. In addition, operation principle, strong and weak points of four main types of protection devices (including fuses, no-fuse circuit breakers, power-electronic protection devices and protective relays) are mentioned. Each different type of protection devices has the ability to protect and isolate different components of the DC microgrid (e.g. power converter, PV system, battery system, capacitor and others) under fault occurrences. The paper analyses possible protection coordination strategies of protection devices to ensure safety of any components in the DC microgrid. These summarized coordination strategies can be suitable for any DC microgrid configurations. In the next content, an effective protection coordination system of a real community-sized DC microgrid is developed, which use fast-acting fuses to replace no-fuse circuit breakers already installed at some certain locations in the DC microgrid. Aims of this improved protection coordination system are to shorten critical fault clearing time and get the cost effectiveness while still ensuring high selectivity, dependability and safety of the DC microgrid. As a result, the no-fuse circuit breakers placed at locations such as: output of PV arrays, output of the battery, output of the fuel-cell system, and terminals of power converters are efficiently replaced by the fast-acting fuses. Additionally, protection devices located at load feeders are suggested to use the relays to optimise the coordination time between main and back-up protection in case of faults occurring at the load feeders.
Perceptual coding at the threshold level for the Digital Cinema System Specification (2010)

An approach to perceptual coding at the threshold level, for supporting the Digital Cinema System Specification (DCSS) standard, is presented. The proposed Perceptual DCSS Coder (PDC) follows the approach of the Visually Lossless Grey scale Image Coder (VLGIC) of adapting Human Visual System (HVS) modelling to the JPEG2000 coder, but extends it to multi-frame application for DCSS. This PDC first applies pixel-domain temporal filtering to video frames. This is followed by the encoding of each colour component of individual frame with the VLGIC. The VLGIC is a JPEG2000 compliant coder that utilises a HVS based vision model to identify and remove imperceptible information in images/frames prior to coding operations. Experimental results show that the PDC provides improvement, in bitrate, over JPEG2000 reversible (lossless) mode. Furthermore, subjective assessments with 16 observers reveal no perceptible differences between PDC coded frames and their respective originals.
Epidemiology of psychiatric disorder (1992)

Empirical evidence relating to four continuing controversies is reviewed: the aetiology and course of schizophrenia; competing explanations of the association between low socioeconomic status, poverty and psychiatric disorders; variability and complexity in the relationship between symptomatology and social functioning; and evaluation of the long-term performance of community-based services.
Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD (2016)

The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d]isothiazol-3(2H)-ones as species-selective inhibitors of Plasmodium spp. 2-C-methyl-<sub>D</sub>-erythritol-4-phosphate cytidyltransferase (IspD), the third catalytic enzyme of the MEP pathway. 2-Phenyl benzo[d]isothiazol-3(2H)-ones display nanomolar inhibitory activity against P. falciparum and P. vivax IspD and prevent the growth of P. falciparum in culture, with EC<sub>50</sub> values below 400 nM. In silico modeling, along with enzymatic, genetic and crystallographic studies, have established a mechanism-of-action involving initial non-covalent recognition of inhibitors at the IspD binding site, followed by disulfide bond formation through attack of an active site cysteine residue on the benzo[d]isothiazol-3(2H)-one core. The species-selective inhibitory activity of these small molecules against Plasmodium spp. IspD and cultured parasites suggests they have potential as lead compounds in the pursuit of novel drugs to treat malaria.
A method for decreasing transport ac losses in multifilamentary and multistrip superconductors (2000)

A new method is proposed for decreasing transport ac losses in multifilamentary superconductors by the decoupling of the filaments using a magnetic material in the form of thin layers surrounding the individual filaments. For a superconductor with an elliptical cross section, the magnetic material surrounding the filaments affects the local magnetic field distribution that both reduces the critical current of the filaments and induces the transport ac losses in the magnetic material. Even by taking into account any detrimental influences of the presence of the magnetic material around the filaments, the analysis of the experimental data supported by computer modelling confirmed that for a Bi2223 tape with 100 filaments individually covered by magnetic material, such as iron powder, the transport ac losses should be 65 times lower than for the same multifilamentary conductor without the magnetic coating on the filaments. With an increasing number of filaments, the ac loss decrease would be even larger.
Overexpression of a maize plasma membrane intrinsic protein ZmPIP1;1 confers drought and salt tolerance in Arabidopsis (2018)

Drought and salt stress are major abiotic stress that inhibit plants growth and development, here we report a plasma membrane intrinsic protein ZmPIP1;1 from maize and identified its function in drought and salt tolerance in Arabidopsis. ZmPIP1;1 was localized to the plasma membrane and endoplasmic reticulum in maize protoplasts. Treatment with PEG or NaCl resulted in induced expression of ZmPIP1;1 in root and leaves. Constitutive overexpression of ZmPIP1;1 in transgenic Arabidopsis plants resulted in enhanced drought and salt stress tolerance compared to wild type. A number of stress responsive genes involved in cellular osmoprotection in ZmPIP1;1 overexpression plants were up-regulated under drought or salt condition. ZmPIP1;1 overexpression plants showed higher activities of reactive oxygen species (ROS) scavenging enzymes such as catalase and superoxide dismutase, lower contents of stress-induced ROS such as superoxide, hydrogen peroxide and malondialdehyde, and higher levels of proline under drought and salt stress than did wild type. ZmPIP1;1 may play a role in drought and salt stress tolerance by inducing of stress responsive genes and increasing of ROS scavenging enzymes activities, and could provide a valuable gene for further plant breeding.
Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century (2003)

Hereditary haemorrhagic telangiectasia (HHT) affects one in 5-8000, and no longer can be viewed as solely causing anaemia (due to nasal and gastrointestinal bleeding) and characteristic mucocutaneous telangiectasia. Arteriovenous malformations commonly occur, and in the pulmonary and cerebral circulations demand knowledge of risks and benefits of asymptomatic screening and treatment. HHT is inherited as an autosomal dominant trait and there is no age cut off when apparently unaffected offspring of an individual with HHT can be told they are unaffected. This review focuses on the evolving evidence base for HHT management, issues regarding pregnancy and prothrombotic treatments, and discusses the molecular and cellular changes that underlie this disease.
The Noncommensal Bacterium Methylococcus capsulatus (Bath) Ameliorates Dextran Sulfate (Sodium Salt)-Induced Ulcerative Colitis by Influencing Mechanisms Essential for Maintenance of the Colonic Barrier Function (2012)

Dietary inclusion of a bacterial meal has recently been shown to efficiently abolish soybean meal-induced enteritis in Atlantic salmon. The objective of this study was to investigate whether inclusion of this bacterial meal in the diet could abrogate disease development in a murine model of epithelial injury and colitis and thus possibly have therapeutic potential in human inflammatory bowel disease. C57BL/6N mice were fed ad libitum a control diet or an experimental diet containing 254 g/kg of body weight BioProtein, a bacterial meal consisting of Methylococcus capsulatus (Bath), together with the heterogenic bacteria Ralstonia sp., Brevibacillus agri, and Aneurinibacillus sp. At day 8, colitis was induced by 3.5% dextran sulfate sodium (DSS) ad libitum in the drinking water for 6 days. Symptoms of DSS treatment were less profound after prophylactic treatment with the diet containing the BioProtein. Colitis-associated parameters such as reduced body weight, colon shortening, and epithelial damage also showed significant improvement. Levels of acute-phase reactants, proteins whose plasma concentrations increase in response to inflammation, and neutrophil infiltration were reduced. On the other, increased epithelial cell proliferation and enhanced mucin 2 (Muc2) transcription indicated improved integrity of the colonic epithelial layer. BioProtein mainly consists of Methylococcus capsulatus (Bath) (88%). The results that we obtained when using a bacterial meal consisting of M. capsulatus (Bath) were similar to those obtained when using BioProtein in the DSS model. Our results show that a bacterial meal of the noncommensal bacterium M. capsulatus (Bath) has the potential to attenuate DSS-induced colitis in mice by enhancing colonic barrier function, as judged by increased epithelial proliferation and increased Muc2 transcription.
Emerging Technologies in Surfactant-Enhanced Subsurface Remediation (1995)

Conventional pump-and-treat remediation has met with limited success, often due to the presence of residual saturation or strongly sorbed compounds. Innovative technologies are necessary to overcome these mass transfer limitations. Surfactant-based technologies have the potential to significantly enhance subsurface remediation. Examples of surfactant based technologies include enhanced contaminant extraction, improved bioavailability, and enhanced retardation via sorbing barriers. This chapter provides an introductory discussion of subsurface remediation, surfactant fundamentals, and surfactant-based remediation technologies. Finally, an overview of this volume (and the sessions from which it resulted) is provided.
Long-term outcomes--mycophenolate mofetil treatment for lupus nephritis with addition of tacrolimus for resistant cases (2010)

Thirty-six MMF-treated patients (51%) remained in CR, and 23 (33%) failed treatment at last follow-up. Time to treatment failure was associated with persistent hypoalbuminaemia (hazard ratio (HR) = 0.87; 95%CI, 0.81-0.95; P = 0.001), higher proteinuria (HR = 1.29; 95%CI, 1.03-1.62; P = 0.030) and fewer early responses (HR 0.28; 95%CI, 0.10-0.77; P = 0.014). Renal relapse occurred in 24 (34%) patients. Time to flare was associated with persistent anti-dsDNA titres (HR = 1.001; 95%CI, 1.001-1.003; P = 0.005) and younger age at inclusion (HR = 0.36; 95%CI, 0.14-0.90; P = 0.029). Tacrolimus was added to 17 (24%) patients. A significant reduction of proteinuria was already observed at 3 months (P = 0.002). After 2 years follow-up, 12 (70%) of them achieved clinical response (six CR and six PR). Conclusions. MMF is an effective treatment for LN. Combination therapy with tacrolimus is an effective and safe alternative for MMF-resistant patients.
Palladium-catalyzed synthesis of indoles via ammonia cross-coupling–alkyne cyclization (2011)

The synthesis of indoles via the metal-catalyzed cross-coupling of ammonia is reported for the first time; the developed protocol also allows for the unprecedented use of methylamine or hydrazine as coupling partners. These Pd/Josiphos-catalyzed reactions proceed under relatively mild conditions for a range of 2-alkynylbromoarenes.
Homogeneous nucleation and glass transition temperatures in solutions of lithium salts in water-d2 and water. Doubly unstable glass regions (1981)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTHomogeneous nucleation and glass transition temperatures in solutions of lithium salts in water-d2 and water. Doubly unstable glass regionsC. A. Angell, E. J. Sare, J. Donnella, and D. R. MacFarlaneCite this: J. Phys. Chem. 1981, 85, 11, 1461–1464Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/j150611a001https://doi.org/10.1021/j150611a001research-articleACS PublicationsRequest reuse permissionsArticle Views320Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Relationship of tumor prostaglandin levels to early recurrence in women with primary breast cancer: clinical update. (1986)

We have determined the levels of prostaglandin E (PGE) and PGF in 94 and 111 primary breast carcinoma specimens, respectively. Tumor specimens were obtained at the time of surgery for primary breast cancer from women without detectable metastatic disease (other than local lymph nodes). Prostaglandins were solvent extracted from tissue homogenates, separated into class by silicic acid chromatography and PG levels determined by radioimmunoassay. These findings were compared to clinically established prognostic indicators. All samples analyzed contained measurable amounts of both PG with a high correlation between levels of PGE and PGF. No association was seen between PG levels and either degree of lymph node involvement, or estrogen receptor. With increasing tumor grade (less differentiation, more pleomorphic nuclei, numerous mitotic figures) higher levels of both PGs were seen, but this association was not statistically significant. These women have been observed for an average of 30 months postsurgery. During that period 20% of tumors have recurred. No significant association were seen between either prostaglandin and the development of recurrent disease or death due to breast cancer. In contrast to published findings, we saw lower than average levels of both E and F in tumors metastasizing to the bone.
Read Performance: The Newest Barrier in Scaled STT-RAM (2014)

Spin-torque transfer RAM (STT-RAM), a promising alternative to static RAM (SRAM) for reducing leakage power consumption, has been widely studied to mitigate the impact of its asymmetrically long write latency. However, physical effects of technology scaling down to 45 nm and below, in particular, process variation, introduce the previously unreported and alarming trends in read performance and reliability due to reduced sensing margins and increasing error rates. In this brief, we study the scaling trends of STT-RAM from 65 down to 22 nm as they pertain to read performance, including a 50% increase in sensing versus peripheral circuit delay ratio and a more than 80% increase in uncorrectable read error rates. Through differential sensing, we show how 22 nm can return to sense delay ratio levels at 65 nm and uncorrectable read errors can be reduced by an order of magnitude. Through a case study of a multilevel STT-RAM cache, we show how a reconfigurable cache cell can create an extreme access mode (X-mode) based on differential sensing improve to outperform the state-of-the-art STT-RAM caching techniques in both raw performance and performance per watt by more than 10% while still reducing energy consumption over SRAM caches by more than 1/3.
Predicting the performance of wide area data transfers (2002)

As Data Grids become more commonplace, large data sets are being replicated and distributed to multiple sites, leading to the problem of determining which replica can be accessed most efficiently. The answer to this question can depend on many factors, including physical characteristics of the resources and the load behavior on the CPUs, networks, and storage devices that are part of the end-to-end path linking possible sources and sinks. We develop a predictive framework that combines (1) integrated instrumentation that collects information about the end-to-end performance of past transfers, (2) predictors to estimate future transfer times, and (3) a data delivery infrastructure that provides users with access to both the raw data and our predictions. We evaluate the performance of our predictors by applying them to log data collected from a wide area testbed. These preliminary results provide insights into the effectiveness of using predictors in this situation.
Prediction of mechanical properties of a minute electronic device with porous ceramic (2007)

Resumen en: It is difficult to measure the mechanical properties of the barrier rib materials in PDP (plasma display panel), which is a composite material reinforce...
Learning to rank for alert triage (2016)

As cyber monitoring capabilities expand and data rates increase, cyber security analysts must filter through an increasing number of alerts in order to identify potential intrusions on the network. This process is often manual and time-consuming, which limits the number of alerts an analyst can process. This generation of a vast number of alerts without any kind of ranking or prioritization is often referred to as alert desensitization [1]. This is the phenomenon where competent analysts become so numbed by the barrage of false positives that they are unable to identify the true positives, leading to unfortunate breaches. Our goal is to alleviate alert desensitization by placing the most important alerts at the front of the queue. With less time and energy expended investigating false positives, critical alerts may not be overlooked allowing timely responses to potential breaches. This paper discusses the use of supervised machine learning to rank these cyber security alerts to ensure that an analyst's time and energy are focused on the most important alerts.
Effect of Changes in Inspired Oxygen Tension on Wound Metabolism (1974)

This work was prompted by earlier findings of the beneficial effect of increased oxygen supply on wound healing. Enzyme activities in the limiting step of glycolysis, citric acid cycle and pentose phosphate cycle were determined in cellulose sponge implants of rats chronically, breathing 12% O(2), air or 55% O(2.) Respiratory gas tensions and concentrations of pyruvate and lactate were measured in wound fluid aspirated from the implants. Significant portions of repair tissue exist in conditions of extremely low oxygen tension. Probably because all added oxygen is readily consumed, the wound fluid PO(2) increased only slightly in hyperoxic environment. The wound PCO(2) increased in parallel with the inspired PO(2), probably due to enhanced production of carbon dioxide. Hyperoxia shifted the wound metabolism from anaerobic towards aerobic glycolysis. This occurred concurrently with activation of citric acid cycle. Succinic dehydrogenase, a linking enzyme between citric acid cycle and electron transfer chain, also increased with increasing oxygen tension. This oxygen-induced metabolical change has been previously observed in many other tissues.
Comparative study of the effect of green and roasted water extracts of mate (<i>Ilex paraguariensis</i>) on glucosyltransferase activity of<i>Streptococcus mutans</i> (2011)

Glucosyltransferase (GTF) plays an important role in the development of dental caries. This study was carried out to compare the efficiency of green mate (GM) and roasted mate (RM) water extracts, drinks rich in polyphenolic compounds consumed in the subtropical region of South America, on the extracellular GTF activity from Streptococcus mutans. The RM extract exhibited a greater inhibitory effect (IC₅₀ of 10 mg/mL) despite presenting lower polyphenolic content. The kinetic analysis showed that there were significant differences (P < 0.05) between the extracts with respect to the values for K(m) and K(i), whereas the values for V(max) were the same, implying the competitive nature of GTF inhibition. GTF activity was also measured using selected polyphenols as inhibitors, and the most effective inhibitors were rutin and caffeoylshikimic acid. The characterization of the extracts by ESI-MS and UPLC-MS showed that the compounds formed during roasting, possibly shikimic acid derivatives and other unindentified compounds formed by the Maillard reaction, appeared to contribute to the inhibition of GTF activity.