gebhart/patrepeval huggingface dataset:
Pulmonary vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis (2009)

These results provide evidence that excessive NO production may mediate pulmonary vascular hyperpermeability in MRSA sepsis via up regulation of reactive radicals and VEGF.
Doublet-triplet splitting and fermion masses with extra dimensions (1999)

The pseudo Goldstone boson mechanism for the ``doublet-triplet splitting'' problem of the grand unified theory can be naturally implemented in the scenario with extra dimensions and branes. The two SU(6) global symmetries of the Higgs sector are located on two separate branes while the SU(6) gauge symmetry is in the bulk. After including several vector-like fields in the bulk, and allowing the most general interactions with their natural strength (including the higher dimensional ones which may be generated by gravity) which are consistent with the geometry, a realistic pattern of the standard model fermion masses and mixings can be naturally obtained without any flavor symmetry. Neutrino masses and mixings required for the solar and atmospheric neutrino problems can also be accommodated. The geometry of extra dimensions and branes provides another way to realize the absence of certain interactions (as required in the pseudo Goldstone boson mechanism) or the smallness of some couplings (e.g., the Yukawa couplings between the fermions and the Higgs bosons), in addition to the usual symmetry arguments.
A new complementary transistor structure for analog integrated circuits (1980)

A new complementary transistor structure has been developed. This paper presents a new technique which provides a fully complementary transistor structure for analog integrated circuits. The pnp transistor is fabricated by triple diffusion process in n type epitaxial layer on p type substrate, and is isolated from the substrate by inserting n- ion implanted layer between p+ collector buried layer and the substrate. This technique results in 5 to 10 times improvement in gain bandwidth product f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> , maximum collector current I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C(max)</inf> and collector saturation voltage V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CE(sat)</inf> in comparison with conventional pnp transistors. Consequently, a fully complementary pnp transistor to npn transistors can be obtained.
Paraxanthine: Connecting Caffeine to Nitric Oxide Neurotransmission (2013)

Recent results obtained in our laboratory indicate that paraxanthine, the main metabolite of caffeine in humans, produces a significantly stronger locomotor activation in rats than caffeine. Furthermore, paraxanthine also produced a very significant increase in striatal extracellular concentrations of dopamine. Searching for an additional mechanism other than adenosine antagonism responsible for these psychostimulant-like effects, it was found that paraxanthine, but not caffeine, inhibited cGMP-preferring phosphodiesterases. Furthermore, interrupting nitric oxide neurotransmision (inhibiting nitric oxide synthase) significantly decreased both the locomotor-activating and the dopamine-releasing effects of paraxanthine. These results open up some obvious questions about the role of paraxanthine in the pharmacological effects of caffeine.
Nonchemical Control of Bed Bugs (2006)

American Entomologist • Volume 52, Number 2 Of all the pests that I have dealt with during undergraduate projects, through graduate school, and during five years in the pest control industry, bed bugs are the ultimate in terms of difficulty and intensity of measures needed to achieve satisfactory control. This is the first pest I have encountered for which nonchemical methods are not just an option or substitute for chemical control, but a necessary and mandatory first step for reducing and controlling infestations. When providing control recommendations against bed bugs, nonchemical measures should be foremost in the list of required practices, and chemical measures should be used only as a remedial (or second-line) measure. As I summarize my experiences with current nonchemical measures, keep in mind that supportive research in this area is modest to nonexistent. To date, the development of control measures against bed bugs has been a matter of trial and error, in which a decrease in control failures (and therefore fewer re-treatments) has been the sole measure of the success of the strategy. Several of the nonchemical methods currently used against bed bugs are proper and thorough inspections, vacuuming, steaming, isolation and cleaning of infested garments, thermal treatments, and use of mattress covers. In addition, a few creative measures have been tried or suggested, the merits of which have yet to be rigorously evaluated. A quick summary of nonchemical measures may be useful.
Fibroblast Growth Factor-2, But Not Vascular Endothelial Growth Factor, Upregulates Telomerase Activity in Human Endothelial Cells (2003)

FGF-2, but not VEGF, restores telomerase activity and maintains the replicative capacity of endothelial cells.
Comparison of tandem and conventional mass spectrometry using electron capture negative ionization in the detection of chemically oxidized dexamethasone in human plasma (1990)

Chemistry and Biochemistry, Michigan State University, East Lansing, Michigan, USA Dexamethasone, a synthetic steroid, can be oxidized chemically to a ketonic steroid structure that is readily detected by electron capture negative ionization mass spectrometry (ECNI/MS). Previous work from this laboratory has demonstrated that the chemical oxidation procedure provides advantages of low detection limits and high selectivity for detection of oxidized dexamethasone against chemical background that would otherwise interfere with detection of this steroidal drug in biological samples using more conventional methodology. This report describes the extent to which tandem mass spectrometry (MS/MS) can further enhance the selectivity of the oxidation/ECNI methodology for the detection of dexamethasone during the analysis of human plasma and presents evidence that sample introduction by direct inlet probe (DIP) can be used successfully under ECNI conditions. For purposes of comparing the methodologies, the same human plasma samples are analyzed by ECNI, first with detection by conventional mass spectrometry using selected ion monitoring (SIM) and then by MSIMS using selected reaction monitoring (SRM) with sample introduction by the gas chromatographic (GC) inlet and by the DIP. The results indicate that use of the DIP is a viable means of sample introduction for ECNI when sample processing involves the specialized oxidation procedure described herein because the sample matrix does not compete significantly for the thermal electrons in the ion source. Whereas SIM and SRM provide comparable results when sample introduction is achieved by the GC inlet, the MS/MS approach offers the possibility for sample introduction using the DIP, which significantly simplifies and shortens the analysis.
A 1/2.7 inch Low-Noise CMOS Image Sensor for Full HD Camcorders (2007)

A 1/2.7 inch 1944times1092pixels CMOS image sensor with multi-gain column amplifier and double noise canceller is fabricated in a 0.18mum 1P3M CMOS process. It operates at 48MHz in a progressive scanning mode at 60fps. A 2T/pixel architecture and low optical stack with micro innerlens achieve 14.8ke <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> /1x-s sensitivity, 14ke <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> saturation, 3.7e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> noise and 12.2e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> dark current at 60degC.
Disruption of disulfide bonds exhibits differential effects on trafficking of regulated secretory proteins (1999)

For several secretory proteins, it has been hypothesized that disulfide-bonded loop structures are required for sorting to secretory granules. To explore this hypothesis, we employed dithiothreitol (DTT) treatment in live pancreatic islets, as well as in PC-12 and GH(4)C(1) cells. In islets, disulfide reduction in the distal secretory pathway did not increase constitutive or constitutive-like secretion of proinsulin (or insulin). In PC-12 cells, DTT treatment caused a dramatic increase in unstimulated secretion of newly synthesized chromogranin B (CgB), presumably as a consequence of reducing the single conserved chromogranin disulfide bond (E. Chanat, U. Weiss, W. B. Huttner, and S. A. Tooze. EMBO J. 12: 2159-2168, 1993). However, in GH(4)C(1) cells that also synthesize CgB endogenously, DTT treatment reduced newly synthesized prolactin and blocked its export, whereas newly synthesized CgB was routed normally to secretory granules. Moreover, on transient expression in GH(4)C(1) cells, CgA and a CgA mutant lacking the conserved disulfide bond showed comparable multimeric aggregation properties and targeting to secretory granules, as measured by stimulated secretion assays. Thus the conformational perturbation of regulated secretory proteins caused by disulfide disruption leads to consequences in protein trafficking that are both protein and cell type dependent.
Secure dynamic code generation against spraying (2010)

DCG (Dynamic Code Generation) technologies have found widely applications in the Web 2.0 era, Dion Blazakis recently presented a Flash JIT-Spraying attack against Adobe Flash Player that easily circumvented DEP and ASLR protection mechanisms built in modern operating systems. We have generalized and extended JIT Spraying into DCG Spraying. Based our analyses on this abstract model of DCG Spraying, we have found that all mainstream DCG implementations (Java/ JavaScript/ Flash/ .Net/ SilverLight) are vulnerable against DCG Spraying attack, and none of the existing ad hoc defenses such as compilation optimization, random NOP padding and constant splitting provides effective protection. Furthermore, we propose a new protection method, INSeRT, which combines randomization of intrinsic elements of machine instructions and randomly planted special trapping snippets. INSeRT practically renders the "sprayed code" ineffective, while alerts the host program of ongoing attacking attempts. We implemented a prototype of INSeRT on the V8 JavaScript engine, and the performance overhead is less than 5%, which should be acceptable in practical application.
The Species of Heterocerus of Boreal America (1890)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Antiphospholipid Antibodies Affect Human Endometrial Angiogenesis: Protective Effect of a Synthetic Peptide (TIFI) Mimicking the Phospholipid Binding Site of β<sub>2</sub>glycoprotein I (2013)

Our results show for the first time the protective effects of TIFI, as represented by its ability to interfere with aPL mediated anti-angiogenic activity.
Middleware for efficient power management in mobile devices (2006)

Mobile computing environment is characterized by limited and dynamically varying available resources and stringent application requirements. Mobile applications are often time-constrained and severely energy constrained as battery power is the only available power source. The power consumed by an application depends on the performance level requested by the user/application. The mobile device can be viewed as the collection of devices such as processor, memory unit, keyboard, display, RF unit etc. Each of these devices can operate at different power states. The power state at which a particular device is operating depends upon the requirement of the application which is using the device. We propose a power management middleware for mobile devices, which not only consider energy savings for the processor but also optimize energy savings for other devices such as display unit, RF unit, keyboard, memory, etc. The proposed approach strives for optimizing the total system power by optimizing the power of individual devices for diverse applications running on the device. Our approach is generic enough to be used on any platform. We have validated our approach by testing two typical mobile applications but our approach can be easily scaled for multiple applications running concurrently.
Nucleoside, VII. Allgemeine Synthese von Pteridin‐<i>N</i>‐8‐glycosiden (1973)

Abstract Es wird eine Methode beschrieben, welche erstmals auf direktem Wege erlaubt, 7‐Oxo‐7,8‐dihydropteridine über die 7‐(Trimethylsiloxy)‐Derivate mit Halogenosen in die entsprechenden 7‐Oxo‐7,8‐dihydropteridin‐ N ‐8‐glycoside zu überführen. Daneben werden in untergeordnetem Maße auch 7‐(Glycosyloxy)pteridine gefunden, die sich chromatographisch abtrennen lassen. Die Strukturen werden UV‐ und NMR‐spektroskopisch ermittelt.
Mueller-matrix measurement using the four-detector photopolarimeter (1986)

A scheme for complete, accurate, and fast determination of the Mueller matrix M of elastic light scattering by a given sample is presented. The Stokes vector of the scattered radiation is virtually instantaneously measured using the recently described four-detector polarimeter (FDP) [Opt. Lett. 10, 309 (1985)] for various input polarizations generated by a fixed polarizer followed by a quarter-wave retarder (QWR) of adjustable fast-axis azimuth C. The output signal vector I of the FDP is recorded at four or more settings of C. If the periodic function I(C) is Fourier analyzed, a series of four terms is obtained whose coefficients determine M column by column. The QWR azimuth C can be changed manually, by a stepping or synchronous motor, or by Faraday-cell magneto-optical rotation, leading to various semiautomatic and fully automatic modes of operation with a range of speed to suit various applications.
Analysis of Gene Sequences by Hybridization of PCR-Amplified DNA to Covalently Bound Oligonucleotide Probes: The Reverse Dot Blot Method (2003)

The introduction of polymerase chain reaction (PCR) technologies (, , , )has greatly simplified the analysis of gene sequences. Prior to PCR, comparison of genes and their alleles required lengthy, tedious, and somewhat difficult procedures. These steps included DNA or RNA purification, cloning of DNA restriction fragments or complementary DNA, subcloning, isolation of the corresponding plasmid, and sequencing of the inserts. PCR has eliminated much of the tedium by allowing amplification of a desired sequence from small amounts of unpurified nucleic acids and direct sequencing of the amplified product. In certain cases one does not need to know the entire sequence of a gene, but only requires detection of a specific allele or mutation. This is true in instances where the sequences of the the majority of the alleles or mutations in the population are already known. For example, the RAS oncogene system () has three loci with cancer-associated mutations occurring at three codons, 12,13, and 61. Over 60 mutations have been discovered at the cystic fibrosis (CF) locus (), but a few predominant mutations in the Caucasian population account for 70–90% of the known cases. Similarly, the HLA Class II locus is very polymorphic (), and detection of allelic, single bp differences are important in forensics, paternity determination, transplantation, and so on.
Magnetostrictive materials and ultrasonics (1996)

In the early 1970s a group of Navy scientists led by A.E. Clark began experimenting with highly magnetostrictive rare earth metals, substances that would lengthen in response to a magnetic field. By 1976 the group had discovered an alloy of iron and terbium that exhibited tremendous levels of magnetostriction. They also discovered that, by adding dysprosium, they could lessen the degree of anisotropy in the magnetization of the alloy. Clark named the new material Terfenol-D after terbium, iron, the Naval Ordinance Lab, and dysprosium. Because Terfenol-D was originally developed for sonar applications, it was regarded as usable at low frequencies only from direct current (dc) to 2 kHz. Furthermore, eddy current activity was believed to be so great that high-frequency operation was deemed impractical. However, Terfenol-D can be used into the ultrasonic frequency range. It exhibits the greatest magnetostrictive effects of any commercially available material and is now positioned for a wide range of high-frequency uses--in which piezoceramic materials were formerly used exclusively. The authors have harnessed the energy efficiency of this alloy and discuss the use of this material in actuators.
Do we need metamodels AND ontologies for engineering platforms? (2006)

In this paper we show how the joint use of metamodeling and ontologies allows to describe domain knowledge for a complex domain. Ontologies are used as stabilized descriptions of a business domain while metamodels allow a fine description of the domain (to be constructed in the initial phases of modeling). We propose to use an ontology for early categorization, i.e., as a "natural" complement of the formal system that is induced by the metamodel.
Regulation of G Protein-coupled Receptor Kinases by Caveolin (1999)

G protein-coupled receptor kinases (GRKs) have been principally characterized by their ability to phosphorylate and desensitize G protein-coupled receptors. However, recent studies suggest that GRKs may have more diverse protein/protein interactions in cells. Based on the identification of a consensus caveolin binding motif within the pleckstrin homology domain of GRK2, we tested the direct binding of purified full-length GRK2 to various glutathione S-transferase-caveolin-1 fusion proteins, and we discovered a specific interaction of GRK2 with the caveolin scaffolding domain. Interestingly, analysis of GRK1 and GRK5, which lack a pleckstrin homology domain, revealed in vitro binding properties similar to those of GRK2. Maltose-binding protein caveolin and glutathione S-transferase-GRK fusion proteins were used to map overlapping regions in the N termini of both GRK2 and GRK5 that appear to mediate conserved GRK/caveolin interactions. In vivo association of GRK2 and caveolin was suggested by co-fractionation of GRK2 with caveolin in A431 and NIH-3T3 cells and was further supported by co-immunoprecipitation of GRK2 and caveolin in COS-1 cells. Functional significance for the GRK/caveolin interaction was demonstrated by the potent inhibition of GRK-mediated phosphorylation of both receptor and peptide substrates by caveolin-1 and -3 scaffolding domain peptides. These data reveal a novel mode for the regulation of GRKs that is likely to play an important role in their cellular function.
Low-complexity PDoA-based localization (2016)

Localization of wireless nodes within the IoT received much attention lately. However, strong constraints on power consumption, scalability, and complexity of the nodes pose a big challenge for localization techniques. This paper presents a concept for energy-efficient low-complexity localization based on Phase Difference of Arrival (PDoA). Besides a novel method for reference transmitter selection we propose a waveform, well-suited for PDoA measurements, and evaluate its ranging performance. We compare multiple signal classification (MUSIC), linear fitting, and mean phase difference and compare their estimation variance to the Cramer Rao Lower Bound (CRLB). Our system concept allows for the mitigation of near-far effects for reference and tag signals at the receiver nodes, and an efficient implementation of a wideband frequency hopping scheme.
Optimal Control Formulation for Determining Optical Flow (2003)

An optimal control formulation for determining optical flow is presented. The new framework differs from preceding approaches in that it does not require differentiation of the data and does combine optical flow with image reconstruction. It can be considered as a control-in-the-coefficients problem with a cost functional of tracking type. A numerical algorithm that solves the optimality system consisting of hyperbolic and elliptic partial differential equations is presented. Numerical experiments demonstrate the effectiveness of the optimal control approach.
A Study on Depression among Pre-University Students Kazeron City 1379-80 (2001)

Objective: The ultimate goal of this research is determining of depression prevalence and effective factors among boys of pre university level in Kazeron city. Materials & Methods: The present research is an analytical - descriptive and cross sectional study, which was done in February 2001. In order to achieve the goal, 240 pre university boys were selected through random classified sampling and the data gathered by questionnaires and Zung depression scale. Results: The results indicate that 42.9 percent of students suffered from depression. The rate of depression among the students is as follows: low depression 28.8%, medium depression 9.6% high depression 3.3%, and profound depression 1.3%. The statistical test, such as X2 and X2 for trend has been used. The results showed that there is a significant relationship between depression and family financial status, parents’ relations, talking about problems with others, anxiety about joining to military services, anxiety for entering to university, treatment of teachers and principals and educational level of mothers. With respect to the above mentioned variables and using a logistic regression model the following results achieved: Four variables had increasing effect on depression incidence: family financial status, parents’ relations, talking about problems with others and anxiety about going to military duty. Conclusion: The advantage of the above model is not only to identify the effectiveness of the variables in depression but also by understanding of the students it is likely to prevent depression incidence.
Multifunctional integrated sensor in A 2&#x00D7;2 mm epitaxial sealed chip operating in a wireless sensor node (2014)

We present multifunctional integrated sensors (abbreviated MFISES) that combine temperature, humidity, pressure, air speed, chemical gas, magnetic, and acceleration sensing on a single 2×2 mm chip. We fabricate MFISES in a wafer scale encapsulation process (called epi-seal) to hermetically seal the sensor functions with moving parts at low vacuum, and then surface micromachine the environmental sensors on top of the sealed layer. The encapsulation process provides very stable conditions for the pressure, magnetic, and acceleration sensors and enables the deployment of MFISES in dynamic environmental conditions without special packaging post-process. We demonstrate MFISES in a sensor node that combines energy harvesting, power management, and low power electronics to wirelessly transmit sensor data using a cloud-based service. The data can be processed and stored using server-side internet tools and then shared with any internet connected device. MFISES combined with the sensor node hardware demonstrates pivotal enabling technology in the emerging areas of wireless sensor networks and the Internet of Things.