gebhart/patrepeval huggingface dataset:
Polypeptides of Treponema pallidum: progress toward understanding their structural, functional, and immunologic roles. Treponema Pallidum Polypeptide Research Group (1993)

Treponema pallidum subsp. pallidum, the spirochete that causes syphilis, is unusual in a number of respects, including its small genome size, inability to grow under standard in vitro culture conditions, microaerophilism, apparent paucity of outer membrane proteins, structurally complex periplasmic flagella, and ability to evade the host immune responses and cause disease over a period of years to decades. Many of these attributes are related ultimately to its protein content. Our knowledge of the activities, structure, and immunogenicity of its proteins has been expanded by the application of recombinant DNA, hybridoma, and structural fractionation techniques. The purpose of this monograph is to summarize and correlate this new information by using two-dimensional gel electrophoresis, monoclonal antibody reactivity, sequence data, and other properties as the bases of polypeptide identification. The protein profiles of the T. pallidum subspecies causing syphilis, yaws, and endemic syphilis are virtually indistinguishable but differ considerably from those of other treponemal species. Among the most abundant polypeptides are a group of lipoproteins of unknown function that appear to be important in the immune response during syphilitic infection. The periplasmic flagella of T. pallidum and other spirochetes are unique with regard to their protein content and ultrastructure, as well as their periplasmic location. They are composed of three core proteins (homologous to the other members of the eubacterial flagellin family) and a single, unrelated sheath protein; the functional significance of this arrangement is not understood at present. Although the bacterium contains the chaperonins GroEL and DnaK, these proteins are not under the control of the heat shock regulon as they are in most organisms. Studies of the immunogenicity of T. pallidum proteins indicate that many may be useful for immunodiagnosis and immunoprotection. Future goals in T. pallidum polypeptide research include continued elucidation of their structural locations and functional activities, identification and characterization of the low-abundance outer membrane proteins, further study of the immunoprotective and immunodiagnostic potential of T. pallidum proteins, and clarification of the roles of treponemal proteins in pathogenesis.
Cladribine in the treatment of IgM paraproteinemic polyneuropathy (2002)

IgM paraproteinemic neuropathy is a progressive and potentially disabling disorder. Treatment with alkylating agents, plasma exchange, corticosteroids, and IV immunoglobulin (IVIG) is frequently unsuccessful.1 Recently, improvement was observed with the purine analog fludarabine.2 We report a patient with IgM monoclonal gammopathy of undetermined significance neuropathy who had a prolonged remission after a short course of cladribine (2-chlorodeoxyadenosine; 2-CDA), a novel purine analog.

A 53-year-old man presented with ascending tingling and numbness of his legs and later of his hands over a 14-month period. His legs felt unsteady, and climbing stairs and arising from a chair became difficult. He was clumsy with his fingers. On examination he had predominantly distal weakness in all limbs and also proximal leg weakness. Reflexes were symmetrically depressed or absent. Plantar responses were flexor. Joint position and vibration sensations in the feet were lost early.

Neurophysiology suggested chronic demyelinating sensorimotor neuropathy. Investigations for neuropathy revealed only an IgM level of 2.67g/L (normal 0.5 to 2.2 g/L) but no other abnormality on protein electrophoresis.

He gradually became …
Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells. (1996)

The human multidrug resistance-associated protein MRP confers resistance to various cytotoxic drugs by lowering the intracellular drug concentration. Recent evidence indicates that MRP can also transport glutathione S-conjugates across membranes. To study the transport properties of MRP in intact cells, we have expressed human MRP cDNA in the polarized pig kidney epithelial cell line LLC-PK1. MRP mainly localized to the basolateral plasma membrane of these cells, and not to the apical membrane, as determined by immunocytochemistry using confocal laser scanning and electron microscopy. In accordance with this localization, MRP caused increased transport of the glutathione S-conjugate S-(2, 4-dinitrophenyl)-glutathione and of the anticancer drug daunorubicin to the basal side of the epithelial cell layer. Sulfinpyrazone and probenecid, known inhibitors of multispecific organic anion transport, inhibited this basolateral transport, but not the apical transport of daunorubicin mediated by the apically localized human MDR1 P-glycoprotein in MDR1-transfected LLC-PK1 cells. Probenecid and sulfinpyrazone may therefore be useful lead compounds for the development of clinical reversal agents specific for MRP-mediated drug resistance.
A rootfinding algorithm for line spectral frequencies (1999)

Published techniques for computing line spectral frequencies (LSFs) generally avoid rootfinding methods because of concerns about convergence and complexity. However, this paper shows that stable predictor polynomials have properties that make rootfinding an attractive approach. It is well known that the problem of finding the LSFs for an N'th order predictor polynomial can be reduced to the problem of finding the roots of a pair of polynomials of order N/2 with real roots. The author extends this result by showing that these polynomials have the following properties: 1. It is possible to select starting points for a Newton's rootfinding method such that the iteration will converge monotonically to the largest root. 2. The Newton iteration can be modified to speed up the process while still maintaining good convergence properties. In this paper, the author presents the rootfinding procedures with proofs of their good convergence properties. Finally, he presents experimental results showing that this procedure performs well on speech signals, and that it can be implemented on fixed-point DSPs.
Cohort Profile: The Study of Health in Pomerania (2010)

Although in the past century mortality in West Germany decreased similarly as in other Western nations, these changes were less pronounced in East Germany. After German reunification in 1990, there was a lack of scientifically valid data from East Germany to explain the regional differences in life expectancy and, consequently, a need for population-based research in northeast Germany.
Temporal Variations in Airborne Particulate Matter Levels at an Indoor Bus Terminal and Exposure Implications for Terminal Workers (2012)

This study investigates temporal variations in PM levels in Taipei bus terminal and assesses exposure levels for bus terminal workers. Measurement results show that temporal variations in PM levels in the waiting room and on the platform of this indoor bus terminal were strongly associated with bus traffic volume. The PM10, PM2.5, and ultrafine particle (UFP) levels on the bus platform were 1.9, 2.0, and 1.2 times higher than those inside the waiting room, respectively. Additionally, PM10 and PM2.5 levels on the platform were approximately 2.3 and 2.8 times higher than those at an ambient monitoring station, respectively. Measurement results indicate that the major PM source inside this bus terminal is diesel buses and that PM can be trapped in this semi-confined bus terminal to a far greater extent than in typical open-air bus stations. Daily PM exposure levels for station ticket inspectors who check passenger tickets in the waiting room and manage arriving and departing buses on the bus platform are assessed. Daily PM exposure levels for station ticket inspectors during different shifts are calculated based on average PM levels and working time spent in the waiting room and on the platform. Based on observational results, station ticket inspectors spend approximately 80–85% and 15–20% of their working time in the waiting room and on the platform, respectively. Daily PM10 and PM2.5 exposure levels for station ticket inspectors were approximately 1.3–1.5 and 1.6–1.8 times higher than those in the outdoor atmosphere, respectively. Additionally, daily UFP exposure levels for station ticket inspectors were approximately 5.6–7.2 times higher than those in the urban background. Measurement results demonstrate that potential health risk induced by PM is high for station ticket inspectors who work for long periods at this indoor bus terminal.
Interfacial chemistry of class II composite restoration: Structure analysis (2005)

The gingival margins of class II composite restorations are particularly vulnerable to marginal leakage and secondary caries. In identifying the factors contributing to caries development, the molecular structure and differences in the structure at the proximal and gingival margins have been largely overlooked. The purpose of this study was to compare the molecular structure at the adhesive/dentin interface of the proximal and gingival walls of class II composite restorations. Class II preparations were cut in 12 unerupted third molars with a water-cooled high-speed dental handpiece. The prepared teeth were randomly selected for treatment with Single Bond (SB) + Z100 (3M). Teeth were restored, per manufacturer's directions, under humidity and temperature characteristic of the oral cavity. Restored teeth were kept in sterile Delbecco's phosphate saline for 48 h. The samples were sectioned occluso-gingivally and micro-Raman spectra were acquired at approximately 1.5-microm spatial resolution across the composite/adhesive/dentin interfaces. Samples were wet throughout spectral acquisition. Raman spectral characteristics at the proximal and gingival margins were distinctly different; the depth of demineralized dentin was 6-7 microm at proximal margin, 12-13 microm at gingival margin. SB adhesive penetrated the depth of demineralized dentin in a gradient at the proximal margin. The "single bottle" adhesive used in this study, gradually penetrated the depth of the demineralized dentin at the proximal margin but failed to infiltrate the depth at the gingival margin, leaving a thick exposed collagen layer.
Inhibition of carbon steel corrosion by azathione derivatives in organic acid solutions (2009)

Purpose The purpose of this paper is to investigate the inhibitive effect of azathiones, namely cyclopentyl‐tetrahydro‐azathione, cyclohexyl‐tetrahydro‐azathione and isobutyl‐methyl‐tetrahydro‐azathione on the corrosion of carbon steel in formic and acetic acid solution. The effect of inhibitor concentration, immersion time, acid concentration, and solution temperature on the inhibition efficiencies of the selected azathiones were studied systematically. Design/methodology/approach The synthesis of inhibitor was confirmed by methods such as Fourier transform infrared and nuclear magnetic resonance studies. All inhibition experiments were conducted on carbon steel in 20 percent formic acid and 20 percent acetic acid solution. Weight loss experiments were carried out according to the American Society for Testing and Materials standard procedure. Polarization studies were carried out in a three electrode cell assembly connected to an EG&G Princeton Applied Research potentiostat/galvanostat (model 173). The electrochemical impedance technique was carried out using Zahner IM‐6 electrochemical workstation at a frequency range of 5‐100 Hz. The scanning electron microscopy (SEM) study was carried out using a VP LEO model no. 435 microscope for the surface characterization of inhibited and uninhibited metal surfaces. Findings Various thermodynamic parameters were calculated using weight loss data in order to elaborate the mechanism of corrosion inhibition. Polarization measurements revealed that the studied azathiones acted predominantly as mixed inhibitors. Electrochemical impedance measurements revealed that the compounds were adsorbed onto the carbon steel surface and the adsorption obeyed the Langmuir adsorption isotherm. The SEM study showed that the inhibited metal surfaces were smoother than were uninhibited metal surfaces. Research limitations/implications The presence of high efficiency and low cost inhibitors is essential for protection of carbon steel. In comparison with conventional carbon steel corrosion inhibitors, these findings would be considered as a step forward in development of new corrosion inhibitor. Originality/value This paper reveals that azathiones can be used successfully for the protection of carbon steel surfaces exposed in acid solution.
Spot reaction experiments. Part X. Topochemical reactions (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpot reaction experiments. Part X. Topochemical reactionsFritz Feigl Cite this: J. Chem. Educ. 1945, 22, 7, 342Publication Date (Print):July 1, 1945Publication History Received3 August 2009Published online1 July 1945Published inissue 1 July 1945https://doi.org/10.1021/ed022p342RIGHTS & PERMISSIONSArticle Views66Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (6 MB) Get e-Alerts Get e-Alerts
Acid Extraction of the Alkaline Wood Pulps (Kraft or SODA/AQ) Before or During Bleaching Reason and Opportunity (1993)

Abstract The decreases in kappa number of an unbleached alkaline hardwood pulp of carpinus betulus when performing dilute H2SO4 hydrolysis at about 100°C, either after or before oxygen bleaching are the same. The main parameters of this acid hydrolysis are specified by studying the acidification of unbleached alkaline pulp suspensions at room temperature, and the extraction kinetics at temperatures in the range of 88°–110°C by following UV absorbance of the hydrolysis liquors. Among the dissolved products in the liquors 2-furancarboxylic acid has been identified. This acid results probably from the degradation in the acid medium of compounds present in the unbleached alkaline pulp, which are not oxidized by oxygen in the alkaline medium.
FIRM: Sampling-based feedback motion-planning under motion uncertainty and imperfect measurements (2013)

In this paper we present feedback-based information roadmap (FIRM), a multi-query approach for planning under uncertainty which is a belief-space variant of probabilistic roadmap methods. The crucial feature of FIRM is that the costs associated with the edges are independent of each other, and in this sense it is the first method that generates a graph in belief space that preserves the optimal substructure property. From a practical point of view, FIRM is a robust and reliable planning framework. It is robust since the solution is a feedback and there is no need for expensive replanning. It is reliable because accurate collision probabilities can be computed along the edges. In addition, FIRM is a scalable framework, where the complexity of planning with FIRM is a constant multiplier of the complexity of planning with PRM. In this paper, FIRM is introduced as an abstract framework. As a concrete instantiation of FIRM, we adopt stationary linear quadratic Gaussian (SLQG) controllers as belief stabilizers and introduce the so-called SLQG-FIRM. In SLQG-FIRM we focus on kinematic systems and then extend to dynamical systems by sampling in the equilibrium space. We investigate the performance of SLQG-FIRM in different scenarios.
Research progress of antirust oil (2015)

Reviewed the major components of the antirust oil,focusing on the classification and mechanism of oil-soluble rust additive. According to the recent research dynamic,the paper pointed out the development trend of the antirust oil,which could have advantages in multifunction use,environmentally friendly and easy preparation.
Effects of multi-element acoustic treatment on compressor inlet noise (1976)

An analytic and experimental study was conducted with the objective of developing both a basic understanding of axially segmented inlet acoustic treatment liners, and design procedures for enhancing the suppression of compressor inlet radiated noise. Anechoic chamber measurements demonstrated that the multielement treatment produced significantly more low frequency suppression than uniform treatment. Further, in-duct spinning mode patterns generated by the rotating vehicle were successfully measured and used as input to an analytical prediction procedure, providing significant improvement in inlet suppression predictions. The study indicated that phased inlet liners can be designed to provide increased noise suppression compared to uniform treatment.
Amine Distribution and Carbon Dioxide Sorption Performance of Amine Coated Silica Aerogel Sorbents: Effect of Synthesis Methods. (2013)

Tetraethylenepentamine (TEPA) modified silica aerogel CO2 adsorbents were prepared by two methods: evaporative precipitation and wet-impregnation. The distribution of amine on the support and CO2 adsorption performance of these sorbents were studied by nitrogen porosimetry, thermogravimetric analysis, transmission electron microscopy, and CO2 gravimetric adsorption analysis to understand the synthesis-structure-CO2 adsorption property relationships of the silica aerogel supported amine sorbents. The sorbents prepared by evaporative precipitation showed slightly better distributions of TEPA and adsorption performance relative to the wet impregnated analogues. The enhancements observed, however, were unexpectedly small suggesting that the two methods of amine immobilization result in similar TEPA distributions. It appears that the thermodynamic limitation toward lowering the free energy of the system is causing the TEPA to consolidate inside the aerogel network, suggesting that methods of impregnation are of little influence on amine distribution within the pore network of the support.
Strong optical forces from adiabatic rapid passage (2007)

Periodic adiabatic rapid passage from counterpropagating light pulses is used in a parameter domain outside of the conventionally expected successful range to produce large optical forces on atoms by coherent control of the momentum exchange between the light and atoms. Both the magnitude and velocity range are much larger than those of the usual radiative force. We observed the force on metastable He atoms by the deflection of the atomic beam with periodic pulse sequences. We have also been able to map out the force magnitude in the two-dimensional parameter space of peak Rabi frequency and sweep range, and we find qualitative agreement with our model.
Sensitivity of color LMMSE restoration of images to the spectral estimate (1991)

The sensitivity to the spectral estimate of the original image of linear minimum mean-square error (LMMSE) color image restoration methods is determined. It is concluded that (i) sensitivity of the full-correlation Wiener restoration to the spectral estimate is higher than that of the independent-channel Wiener restoration, and the full-correlation restoration is extremely sensitive to windowing, (ii) among independent-channel restorations, the ones based on autoregressive spectral estimates are the least sensitive, and (iii) full-correlation Wiener restoration may be outperformed by the independent-channel restoration depending on the prototype image used in spectral estimation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automation of Tool Routines & Analysis for 3D Measurement Systems (1999)

<div class="section abstract"><div class="htmlview paragraph">This paper addresses the steps and processes to create a full life circle of Tool Routines utilizing 3D data analysis as the driver. The paper covers the development of 3D Tool Routines for automation, the execution of the routines and the analysis of the collected historical 3D data. The process goal is to reduce the tool routine frequency by establishing and proving tool stability utilizing historical data. The historical data will also give us information in regards to design and tolerance capabilities. Graphical software programs are evolving in a way that enables us to link the different operations and software programs that encompass tool routines. Through the use of software and hardware such as laser tracker, we can achieve automation of tool routines and analysis. Customers in the aerospace, automotive and construction industries are among the beneficiaries in the application of this inspection process.</div></div>
Voice over IP performance monitoring (2001)

We describe a method for monitoring Voice over IP (VoIP) applications based upon a reduction of the ITU-T's E-Model to transport level, measurable quantities. In the process, 1) we identify the relevant transport level quantities, 2) we discuss the tradeoffs between placing the monitors within the VoIP gateways versus placement of the monitors within the transport path, and 3) we identify several areas where further work and consensus within the industry are required. We discover that the relevant transport level quantities are the delay, network packet loss and the decoder's de-jitter buffer packet loss. We find that an in-path monitor requires the definition of a reference de-jitter buffer implementation to estimate voice quality based upon observed transport measurements. Finally, we suggest that more studies are required, which evaluate the quality of various VoIP codecs in the presence of representative packet loss patterns.
Flavor Components of Miso: Basic Fraction (1983)

Journal Article Flavor Components of Miso: Basic Fraction Get access Yutaka Mori, Yutaka Mori Division of Applied Microbiology, National Food Research Institute, Yatabe, Tsukuba-gun, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Kan Kiuchi, Kan Kiuchi Division of Applied Microbiology, National Food Research Institute, Yatabe, Tsukuba-gun, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Tabei Hideo Tabei Division of Applied Microbiology, National Food Research Institute, Yatabe, Tsukuba-gun, Ibaraki 305, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 47, Issue 7, 1 July 1983, Pages 1487–1492, https://doi.org/10.1080/00021369.1983.10865811 Published: 01 July 1983 Article history Received: 08 November 1982 Published: 01 July 1983