Original Articles: Bladder Cancer: A Randomized Study of Intravesical Mitomycin C, Bacillus Calmette-Guerin Tice and Bacillus Calmette-Guerin RIVM Treatment in pTa-pT1 Papillary Carcinoma and Carcinoma in Situ of the Bladder (1995)

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1995Original Articles: Bladder Cancer: A Randomized Study of Intravesical Mitomycin C, Bacillus Calmette-Guerin Tice and Bacillus Calmette-Guerin RIVM Treatment in pTa-pT1 Papillary Carcinoma and Carcinoma in Situ of the Bladder Peter D.J. Vegt, J. Alfred Witjes, Wim P.J. Witjes, Wim H. Doesburg, Frans M.J. Debruyne, A.P.M. van der Meijden, and E. David Crawford Peter D.J. VegtPeter D.J. Vegt , J. Alfred WitjesJ. Alfred Witjes , Wim P.J. WitjesWim P.J. Witjes , Wim H. DoesburgWim H. Doesburg , Frans M.J. DebruyneFrans M.J. Debruyne , A.P.M. van der MeijdenA.P.M. van der Meijden , and E. David CrawfordE. David Crawford View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67606-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Results of a randomized prospective study are reported in which mitomycin C, Tice bacillus Calmette-Guerin (BCG) and RIVM-BCG were compared in 437 patients with primary or recurrent pTa and pT1 bladder tumors, including carcinoma in situ. The followup (or time in study) varied from 2 to 81 months (mean 36 months). After complete transurethral resection of all visible tumors the patients were treated with 30 mg. mitomycin C once a week for 4 consecutive weeks and thereafter every month for a total of 6 months, and 5 x 108 colony-forming units Tice BCG or RIVM-BCG once a week for 6 consecutive weeks. For papillary tumors mitomycin C and RIVM-BCG treatments were equally effective (p = 0.53), and mitomycin C was more effective than Tice BCG therapy (p = 0.01). References 1 : Use of intravesical bacillus Calmette-Guerin in the treatment of superficial transitional cell carcinoma of the bladder: an overview. Urol. Int.1990; 45: 129. Google Scholar 2 : Bladder cancer immunotherapy. J. Urol.1982; 128: 931. Link, Google Scholar 3 : Treatment of superficial bladder cancer with intravesical BCG. In: Immunotherapy of Human Cancer. Edited by . New York: Elsevier-North Holland1982: 309. sect. 7. Google Scholar 4 : A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette-Guerin for transitional-cell carcinoma of the bladder. New Engl. J. Med.1991; 325: 1205. Google Scholar 5 : Long-term complete remission in bladder carcinoma in situ with intravesical Tice bacillus Calmette Guerin. Overview analysis of six phase II clinical trials. Urology1991; 38: 507. Google Scholar 6 : Intravesical therapy. A critical overview. Urol. Clin. N. Amer.1987; 14: 399. Google Scholar 7 : Long-term mitomycin C instillation after transurethral resection of superficial bladder carcinoma: influence on recurrence, progression and survival. J. Urol.1984; 132: 27. Link, Google Scholar 8 : Role of intravesical mitomycin C in management of superficial bladder tumors. Urology1980; 16: 11. Google Scholar 9 : Evaluation and management of patients with superficial bladder cancer. Urol. Clin. N. Amer.1987; 14: 771. Google Scholar 10 : BCG (RIVM) versus mitomycin intravesical therapy in superficial bladder cancer. First results of randomized prospective trial. Urology1988; 31: 20. Google Scholar 11 : Intravesical bacillus Calmette-Guerin therapy for superficial bladder cancer: effect of bacillus Calmette-Guerin viability on treatment results. J. Urol.1985; 134: 48. Link, Google Scholar 12 : Intravesical Bacillus Calmette-Guerin therapy for murine bladder tumors: initiation of response by fibronectin-mediated attachment of Bacillus Calmette-Guerin. Cancer Res.1987; 47: 1762. Google Scholar 13 : Role of fibronectin in intravesical BCG therapy for superficial bladder cancer. J. Urol.1988; 139: 410. Link, Google Scholar 14 : TNM Classification of Malignant Tumours. Heidelberg: Springer-Verlag1987. Google Scholar 15 : Tumors of the urinary bladder. Atlas of Tumor Pathology, 2nd series. Washington, D. C.: Armed Forces Institute of Pathology1975. fasc. 11. Google Scholar 16 : A randomized prospective study comparing intravesical instillations of Mitomycin-C, BCG-Tice and BCG-RIVM in pTa-pT1 tumors and primary carcinoma in situ of the urinary bladder. Eur. J. Cancer1993; 29A: 1672. Google Scholar 17 : Long-term results of intravesical therapy for superficial bladder cancer. Urol. Clin. N. Amer.1992; 19: 573. Google Scholar 18 : Long-term effect of intravesical bacillus Calmette-Guerin (BCG) Tice strain on flat carcinoma in situ of the bladder. Prog. Clin. Biol. Res.1989; 310: 171. Google Scholar 19 : A prospective randomized trial of maintenance versus nonmaintenance intravesical bacillus Calmette-Guerin therapy of superficial bladder cancer. J. Clin. Oncol.1987; 5: 441. Google Scholar 20 : Single course versus maintenance bacillus Calmette-Guerin therapy for superficial bladder tumors: a prospective, randomized trial. J. Urol.1987; 138: 295. Link, Google Scholar 21 : SWOG 8795: a randomized comparison of bacillus Calmette Guerin and mitomycin C prophylaxis in stage Ta and T1 transitional cell carcinoma of the bladder. J. Urol.1993; 149: 282A. part 2, abstract 275. Google Scholar From the Department of Urology, Rijnland Hospital, Leiderdorp, Bosch Medical Centre, Hertogenbosch, and Departments of Urology and Medical Statistics, University Hospital, Nijmegen, The Netherlands. 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Volume 153Issue 3SMarch 1995Page: 929-933 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Peter D.J. Vegt More articles by this author J. Alfred Witjes More articles by this author Wim P.J. Witjes More articles by this author Wim H. Doesburg More articles by this author Frans M.J. Debruyne More articles by this author A.P.M. van der Meijden More articles by this author E. David Crawford More articles by this author Expand All Advertisement PDF downloadLoading ...