gebhart/patrepeval huggingface dataset:
Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha. (1987)

The effects of various phorbol esters on the interaction of human cells with recombinant human tumor necrosis factor-alpha (rTNF-alpha) was investigated. Preexposure of several different types of cells with only biologically active tumor promoter, i.e. 4 beta-phorbol 12-myristate 13-acetate (PMA), inhibited the specific binding of rTNF-alpha to its receptor. The reduction in specific binding of TNF-alpha was observed only by PMA but not with several other phorbol esters tested. 1-oleoyl-2-acetylglycerol, which is an analogue of the natural protein kinase C activator, diacylglycerol, was active in down-regulating TNF-alpha receptors but only at 1000 times concentration than PMA. Scatchard analysis of the binding data on U-937 cells revealed that PMA caused a decrease in high affinity cell surface receptor number (approximately 8300 versus approximately 2500 binding sites/cell) without any significant change in the dissociation constant (0.38 nM versus 0.32 nM). This decrease in receptor number is dependent on temperature, the time of exposure, and dose of PMA. Greater than 95% of the specific binding of 125I-TNF-alpha could be abolished within 10 min by preexposure of cells to 10 nM PMA at 37 degrees C. The down-regulation of receptors by PMA occurred only at 37 degrees C but not at 4 degrees C, suggesting a probable internalization of the receptors. The specific binding of TNF-alpha to detergent-solubilized cell extracts remained unchanged after exposure of cells to PMA. The rates of dissociation of TNF-alpha from the cell surface and the rate of internalization was not significantly affected by PMA, but the rate of disappearance from cell interior and its appearance into the medium was slightly enhanced by PMA. PMA did not alter the rate of degradation of the TNF-alpha nor cause the shedding of receptors into the medium. Approximately 70% of TNF-alpha cell surface receptors could be regenerated within 16 h after PMA removal. These results suggest the involvement of PMA-activated protein kinase C in down-regulation and redistribution of TNF-alpha receptors.
Local Delivery of Ethanol Inhibits Intimal Hyperplasia in Pig Coronary Arteries After Balloon Injury (1997)

Local delivery of 15% ethanol solution to pig coronary arteries significantly decreased the SMC proliferative activity and neointimal formation induced by balloon dilation injury.
Diffusion‐weighted radial fast spin‐echo for high‐resolution diffusion tensor imaging at 3T (2008)

There is a need for an imaging sequence that can provide high-resolution diffusion tensor images at 3T near air-tissue interfaces. By employing a radial fast spin-echo (FSE) collection in conjunction with magnitude filtered back-projection reconstruction, high-resolution diffusion-weighted images can be produced without susceptibility artifacts. However, violation of the Carr-Purcell-Meiboom-Gill (CPMG) condition of diffusion prepared magnetization is a prominent problem for FSE trains that is magnified at higher fields. The unique aspect of violating the CPMG condition in trajectories that oversample the center of k-space and the implications for choosing the solution are examined. For collecting diffusion-weighted radial-FSE data at 3T we propose mixed-CPMG phase cycling of RF refocusing pulses combined with a 300% wider refocusing than excitation slice. It is shown that this approach produces accurate diffusion values in a phantom, and can be used to collect undistorted, high-resolution diffusion tensor images of the human brain.
A nonlinear stretching based electromagnetic energy harvester on FR4 for wideband operation (2014)

We report a nonlinear stretching-based electromagnetic energy harvester using FR4 as a vibrating spring material due to its low Young's modulus. We show analytically that the nonlinearity is caused by the stretching, in addition to the bending, of the specially designed spring arms; this gives rise to a wider half-power bandwidth of 10 Hz at 1 g acceleration, which is almost 5 times higher than that of a comparable linear counterpart. The output spectra show the first reported experimental evidence of a symmetry broken nonlinear secondary peak in a single potential well system at frequencies close to the nonlinear jump frequency, which may appear to be due to the dynamic symmetry breaking of the oscillator or to the inherent asymmetry of the built prototype. The presence of this secondary peak is useful in generating a significant amount of power compared to the symmetric states, producing ∼3 times more power at the secondary peak than the nearby symmetric states. 110% of the peak power obtained for 0.5 g acceleration is achieved at the secondary peak during the frequency up-sweep. The experimental results are compared with a deterministic numerical model based on the Duffing oscillator, and we include a qualitative discussion on the influence of noise in an experimental energy harvesting system.
Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice (2010)

These data demonstrate that, in the absence of VAMP8, the relative subcellular distribution of GLUT4 is altered, resulting in increased sarcolemma levels that can account for increased glucose clearance and insulin sensitivity.
A compact semi-lumped low-pass filter for harmonics and spurious suppression (2000)

A semi-lumped parallel resonance circuit was employed to design a very compact low-pass filter. The semi-lumped shunt arm consists of a capacitor and a transmission line section. In such an arrangement, two finite attenuation poles can be generated near the passband edge. As a result, the proposed filter enjoys sharper cutoff and fewer filter orders than those of the conventional low-pass filters. In addition, these two attenuation poles can be properly designed to suppress the second and third harmonics generated from power amplifier and frequency source. A low-temperature cofired-ceramic (LTCC) multilayer-ceramic (MLC) low-pass filter and a PCB low-pass filter with a 0402 chip capacitor were designed and tested. Experimental results demonstrate the capability of this filter in harmonics and spurious suppression.
Slice-level rate-distortion optimized multiple description coding for H.264/AVC (2010)

We propose a novel standard-compliant multiple description coding (MDC) method that exploits the H.264/AVC redundant slice tool, performing rate-distortion optimization at the slice level. The strategy to allocate redundancy to each slice jointly takes into account its contribution to distortion, its position in the GOP, the effect of decoder error concealment, and the transmission conditions. This makes the algorithm more accurate with respect to previous frame-based solutions, and experimental results show that it compares favorably with other state-of-the-art standard-compliant MDC techniques.
Placental expression of α and β subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome (1995)

Journal Article Placental expression of α and β subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome Get access Maria L. Brizot, Maria L. Brizot 1Harris Birthright Research Centre for Fetal MedicineKing's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Eric Jauniaux, Eric Jauniaux 1Harris Birthright Research Centre for Fetal MedicineKing's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrew T. Mckie, Andrew T. Mckie 2Department of Molecular MedicineKing's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Farzin Farzaneh, Farzin Farzaneh 2Department of Molecular MedicineKing's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Kypros H Nicolaides Kypros H Nicolaides 3 1Harris Birthright Research Centre for Fetal MedicineKing's College Hospital Medical School, Denmark Hill, London SE5 8RX, UK 3To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Molecular Human Reproduction, Volume 1, Issue 7, 1 September 1995, Pages 358–361, https://doi.org/10.1093/molehr/1.7.358 Published: 01 September 1995 Article history Received: 21 April 1995 Accepted: 14 June 1995 Published: 01 September 1995
A Polylogarithmic-Competitive Algorithm for the <i>k</i> -Server Problem (2015)

We give the first polylogarithmic-competitive randomized online algorithm for the k -server problem on an arbitrary finite metric space. In particular, our algorithm achieves a competitive ratio of Õ(log 3 n log 2 k ) for any metric space on n points. Our algorithm improves upon the deterministic (2 k -1)-competitive algorithm of Koutsoupias and Papadimitriou [Koutsoupias and Papadimitriou 1995] for a wide range of n .
Segregation and desorption kinetics for evaporation of arsenic from silicon (1979)

A significant role of surface segregation in arsenic out-diffusion from silicon is described. After heat treatment of uniformly arsenic-doped silicon in a H2 ambient, the amount of arsenic atoms segregating at the surface is measured using Auger electron spectroscopy. The experimental results are explained by a new model including the segregation effect in the boundary condition in the diffusion equation. Comparing the new model with previous treatments for out-diffusion phenomena, it is indicated that K which has been defined as an evaporation velocity from the solid to the gas phase should be replaced by k1, the rate of the first-order reaction from the solid to the segregation layer at the surface.
Gastric parietal cell H(+)-K(+)-ATPase microsomes are associated with isoforms of ankyrin and spectrin (1993)

Stimulation of HCl secretion by gastric parietal cells requires the fusion of cytoplasmic H(+)-K(+)-ATPase-bearing tubulovesicles with the apical membrane. This insertion of membrane results in a dramatic increase in apical surface area through the formation of microvilli. To elucidate the elements that may stabilize the newly inserted H(+)-K(+)-ATPase within the apical membrane, we searched for specific cytoskeletal proteins associating with the gastric enzyme. We document by immunoblot analysis that ankyrin, spectrin, and actin copurify with H(+)-K(+)-ATPase microsomes prepared from gastric parietal cells. Coprecipitation of 125I-labeled native erythrocyte ankyrin with the H(+)-K(+)-ATPase from gastric microsomes using anti-H(+)-K(+)-ATPase antibodies suggests that ankyrin associates with the H(+)-K(+)-ATPase. Indirect immunofluorescence and confocal microscopy show that ankyrin and H(+)-K(+)-ATPase cosegregate within resting and secreting parietal cells. Taken together, these data suggest that the association of the gastric H(+)-K(+)-ATPase with spectrin and actin is mediated by ankyrin and that this interaction contributes to the maintenance of the polarized distribution of the enzyme to the apical domain of gastric parietal cells during acid secretion.
Double barrier magnetic tunnel junctions with write/read mode select layer (2014)

In this study, special STT-RAM were designed, built and tested, allowing to read and write at similar voltages. This is achieved by maximizing the Spin-Transfer-Torque (STT) efficiency on the storage layer magnetization during write and minimizing it during read. In order to achieve this STT tuning, double barrier magnetic tunnel junctions were prepared wherein the storage layer is sandwiched between two polarizing layers. Each polarizing layer is separated from the storage layer by a tunnel barrier. The magnetization of one of the polarizing layer is always pinned in a fixed direction whereas the other one, called mode select layer, can be switched parallel or antiparallel to the first one depending whether the magnetic tunnel junction (MTJ) is in read or respectively write mode. In the parallel configuration of the polarizing layers, the STT efficiency is minimized allowing to read at relatively high voltage leading to fast readout without risk of write disturb during read. In the antiparallel configuration of the polarizing layer, the STT efficiency is maximized allowing writing at lower current density. In this system, the magnetization of the storage layer is switched by STT whereas the magnetization of the mode select layer is switched by field. Switching from read mode to write mode and vice versa is achieved by sharing a single pulse of magnetic field for all bits of the same word.
Calcium‐Stimulated Proteolysis in Myelin: Evidence for a Ca<sup>2+</sup>‐Activated Neutral Proteinase Associated with Purified Myelin of Rat CNS (1985)

Incubation of myelin purified from rat spinal cord with CaCl2 (1-5 mM) in 10-50 mM Tris-HCl buffer at pH 7.6 containing 2 mM dithiothreitol resulted in the loss of both the large and small myelin basic proteins (MBPs), whereas incubation of myelin with Triton X-100 (0.25-0.5%) and 5 mM EGTA in the absence of calcium produced preferential extensive loss of proteolipid protein (PLP) relative to MBP. Inclusion of CaCl2 but not EGTA in the medium containing Triton X-100 enhanced degradation of both PLP and MBPs. The Ca2+-activated neutral proteinase (CANP) activity is inhibited by EGTA (5 mM) and partially inhibited by leupeptin and/or E-64c. CANP is active at pH 5.5-9.0, with the optimum at 7-8. The threshold of Ca2+ activation is approximately 100 microM. The 150K neurofilament protein (NFP) was progressively degraded when incubated with purified myelin in the presence of Ca2+. These results indicate that purified myelin is associated with and/or contains a CANP whose substrates include MBP, PLP, and 150K NFP. The degradation of PLP (trypsin-resistant) in the presence of detergent suggests either release of enzyme from membrane and/or structural alteration in the protein molecule rendering it accessible to proteolysis. The myelin-associated CANP may be important not only in the turnover of myelin proteins but also in myelin breakdown in brain diseases.
Dilute Acaricide Evaluation Experiment, 1988 (1989)

Abstract Plots consisted of single trees in a randomized block design with 2 replicates of ‘Golden Delicious’ and 2 replicates of ‘Delicious,’ both spur types. The trees were planted to a spacing of 20 x 35 ft. Experimental sprays were applied to run-off with a handgun from a truck-mounted John Bean sprayer equipped with a 35 gal/min pump. Approximately 5.6 gal of spray was applied to each replicate tree (350 gal/acre) except where noted. Spray dates were as follows: 22 Jun, 29 Jun (UBIA-1335 and Omite treatments only), 7 Jul (all treatments but EL-193136 at 0.168 lb [AI]/100 gal, UBIA-1335, and Omite treatments), 18 Jul (Vendex 4 L, Omite 6 E, and Omite 30 W treatments only). General sprays of fungicides (Benlate, Polyram, Manzate, Bayleton, Dithane M-45), insecticides (Lorsban, Phosphamidon, Guthion, Sevin, Pydrin), and calcium chloride were made at 1- to 2-wk intervals throughout the experiment with a Friend Airmaster at 50 gal/acre. Effectiveness of materials against mites was evaluated by making several counts on random samples of 25 leaves/tree. Russet ratings are based on 30 ‘Golden Delicious’ apples/replicate. Fruits were rated as 1 (no russeting), 2 (light russeting), 3 (moderate russeting), or 4 (severe russeting). Possible ranges were 30-60 (none to light), 60-90 (light to moderate), and 90-120 (moderate to severe).
Characterization of a new antibiotic of iturin group: Bacillomycin D. (1980)

The characterization of an antibiotic isolated from a strain of Bacillus subtilis revealed that this compound is a new antifungal antibiotic of the iturin group. It contains a lipid moiety which is a mixture of 3-amino 12-methyl tridecanoic acid (40%) and 3-amino 12-methyl tetradecanoic acid (60%) and a peptide moiety: L-Asp1, D-Asp1, L-Glu1, L-Pro1, D-Ser1, L-Thr1 and D-Tyr1. These two moieties are joined by a threonyl-beta-aminoacid linkage.
Modeling circuits with spins and magnets for all-spin logic (2012)

This talk will summarize our work in the last three years exploring the possibility of spin-magnet circuits that utilize two key recent advances, namely (1) spin valve (SV) devices demonstrating spin injection into metals and semiconductors from magnetic contacts and (2) spin transfer torque (STT) devices demonstrating the switching of magnets by the injected spins. Utilizing an experimentally benchmarked model describing these phenomena we have shown the possibility of Boolean all-spin logic (ASL) circuits with intrinsic directionality or with directionality enforced through STT based Bennett clocking. We also discuss probabilistic ASL circuits and summarize the modeling framework that we have developed for the analysis of generic spin-magnet circuits.
Analysis and design of current probe transition from grounded coplanar to substrate integrated rectangular waveguides (2005)

The transition between a grounded coplanar waveguide (GCPW) and a substrate integrated rectangular waveguide (SIRW) is investigated in this paper. The proposed scheme makes use of a current probe to transfer power between the two dissimilar transmission lines. A computer-aided-design-oriented analytical model is developed in order to optimize the geometrical dimensions of the transition. By using the GCPW instead of the microstrip line to interface the SIRW, substrate thickness can be increased without incurring a penalty due to transmission loss. Therefore, it is possible to achieve higher Q components. Experiments at 28 GHz show that an effective bandwidth of 10% can easily be obtained. The insertion loss is less than 0.73 dB over the bandwidth of interest.
Reasoning with uncertainty for expert systems (1985)

For CABG patients more than 70 years old with minimal comorbidities especially in the presence of aortic gradients of 26/15 mm Hg or greater, concomitant AVR for moderate aortic stenosis should be performed during CABG and may be performed with minimal additional operative risk. Patients with significant comorbidities should be managed with CABG alone, owing to an increased perioperative risk, poor midterm survival, and minimal risk of AVR at 5 years.
Endothelial Cell Tube Formation Assay for the <em>In Vitro</em> Study of Angiogenesis (2014)

Angiogenesis is a vital process for normal tissue development and wound healing, but is also associated with a variety of pathological conditions. Using this protocol, angiogenesis may be measured in vitro in a fast, quantifiable manner. Primary or immortalized endothelial cells are mixed with conditioned media and plated on basement membrane matrix. The endothelial cells form capillary like structures in response to angiogenic signals found in conditioned media. The tube formation occurs quickly with endothelial cells beginning to align themselves within 1 hr and lumen-containing tubules beginning to appear within 2 hr. Tubes can be visualized using a phase contrast inverted microscope, or the cells can be treated with calcein AM prior to the assay and tubes visualized through fluorescence or confocal microscopy. The number of branch sites/nodes, loops/meshes, or number or length of tubes formed can be easily quantified as a measure of in vitro angiogenesis. In summary, this assay can be used to identify genes and pathways that are involved in the promotion or inhibition of angiogenesis in a rapid, reproducible, and quantitative manner.
Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand (2002)

FP-CIT SPET provides a means of distinguishing DLB from AD during life.
A Study on Socio Demographic, Clinical Profile and Outcome of Breast Cancer Patients Attending Tertiary Cancer Care Centre in Gujarat State (2021)

Introduction: Breast cancer is second most common cancer all over the world. Majority of breast cancer cases are registered to hospital at a later stage of cancer presentation. Objective: To study socio-demographic, clinical presentation and outcome of Breast cancer patients attending tertiary care centre of Gujarat state. Method: This was a retrospective study made up of 5774 patients registered in tertiary care centre of Gujarat state. Data including patient’s socio-demographic information like age, marital status, education level and clinical diagnosis including clinical presentation at time of registration, treatment history etc was collected. The data was analysed using MS office 2010 and Epi Info software version 7.0. Result: The age ranged between 17-99 years, with a median of 50 years and interquartile range of 42-58 years. There were 62.07% patients presented with locally advanced breast cancer, while 17.57% patients had distant metastasis at diagnosis. Significant association (p<0.05) was found between presentation of disease and literacy status. The overall Kaplan-Meier survival rate at 5 years was 35.8% + 5.0%. Survival rate was consistently declining with increase in clinical extension of disease. Conclusion: Majority of patients were in early advanced stage during their first hospital visit which was associated with poor survival. This information may help authorities to focus on early diagnosis of breast cancer.
Polymer Science and Technology: A Status Report (1983)

Abstract Polymers are very important and used in homes, cars, offices, and hospitals-almost everywhere, in fact. Without them, modern life would be very difficult if not impossible. This paper describes the current status of polymer science and technology. Future trends and prospects in polymer materials are also elaborated. The question of alternative raw material resources is addressed. The rapid growth of polymer materials in the past resulted from innovative ideas and the dedication of many chemists and engineers. Current problems are availability and high cost of petroleum raw materials and energy, increased labor costs, increased processing costs, environmental regulations, an overwhelming emphasis on short-range application research with the goal of almost immediate marketability, and cutbacks in fundamental and exploratory research. These trends, unless reversed, do not auger well for continued growth of polymers at anything approaching the 1945–1975 rate.