gebhart/patrepeval huggingface dataset:
Targeting Protein Tyrosine Kinase 6 Enhances Apoptosis of Colon Cancer Cells following DNA Damage (2012)

Protein tyrosine kinase 6 (PTK6) is an intracellular tyrosine kinase that has distinct functions in normal epithelia and cancer. It is expressed primarily in nondividing epithelial cells in the normal intestine, where it promotes differentiation. However, after DNA damage, PTK6 is induced in proliferating progenitor cells, where it contributes to apoptosis. We examined links between PTK6 and the tumor suppressor p53 in the isogenic p53(+/+) and p53(-/-) HCT116 colon tumor cell lines. We found that p53 promotes expression of PTK6 in HCT116 cells, and short hairpin RNA-mediated knockdown of PTK6 leads to reduced induction of the cyclin-dependent kinase inhibitor p21. Knockdown of PTK6 enhances apoptosis in HCT116 cells with wild-type p53, following treatment of cells with γ-radiation, doxorubicin, or 5-fluorouracil. No differences in the activation of AKT, ERK1/2, or ERK5, known PTK6-regulated prosurvival signaling proteins, were detected. However, activity of STAT3, a PTK6 substrate, was impaired in cells with knockdown of PTK6 following DNA damage. In contrast to its role in the normal epithelium following DNA damage, PTK6 promotes survival of cancer cells with wild-type p53 by promoting p21 expression and STAT3 activation. Targeting PTK6 in combination with use of chemotherapeutic drugs or radiation may enhance death of colon tumor cells with wild-type p53.
Recognizing Nano SnO as an Electrode Material for Electrochemical Double Layer Capacitors (2005)

Abstract In this communication, we recognize the electrochemical capacitance behavior of SnO (tin(II) oxide) nanoparticles in aqueous solutions. TEM image shows the SnO nanoparticles synthesized via hydrothermal method to be in the nano scale range. The nanomaterial was immobilized on paraffin-impregnated graphite electrode to preserve the high surface area of SnO nanoparticles which plays a crucial role in preserving the electrochemical activity. In 0.1 M NaCl solutions, nano SnO provided a high cell voltage of 1.65 V vs Ag/AgCl and the nanomaterial was chemically and electrochemically stable over 1000 cycles of potentiodynamic and charge–discharge measurements.
Wenn der Kunde mit den Füßen abstimmt (2007)

Die Zeitschrift informiert über Trends in der Sozialwirtschaft und beantwortet Fragen der Organisation und Finanzierung sozialer Dienstleistungen. Das Magazin stellt Persönlichkeiten und Unternehmen der Branche vor und zeigt neue Lösungen für das Führen sozialer Betriebe. Kommentare, Interviews und Glossen bieten pointierte Orientierungspunkte für die Leitungspraxis.
Blockchain Based Data Integrity Service Framework for IoT Data (2017)

It is a challenge to ensure data integrity for cloud-based Internet of Things (IoT) applications because of the inherently dynamic nature of IoT data. The available frameworks of data integrity verification with public auditability cannot avoid the Third Party Auditors (TPAs). However, in a dynamic environment, such as the IoT, the reliability of the TPA-based frameworks is far from being satisfactory. In this paper, we propose a blockchain-based framework for Data Integrity Service. Under such framework, a more reliable data integrity verification can be provided for both the Data Owners and the Data Consumers, without relying on any Third Party Auditor (TPA). In this paper, the relevant protocols and a subsequent prototype system, which is implemented to evaluate the feasibility of our proposals, are presented. The performance evaluation of the implemented prototype system is conducted, and the test results are discussed. The work lays a foundation for our future work on dynamic data integrity verification in a fully decentralized environment.
He–Ne Laser with Perpendicular End Windows (1964)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. D. Mielenz, K. F. Nefflen, and K. E. Gillilland, "He–Ne Laser with Perpendicular End Windows," Appl. Opt. 3, 785-786 (1964) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Sphingosine 1-Phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo (2009)

CD4(+)CD25(+) regulatory T cell (Treg) entry into secondary lymphoid organs and local expansion is critical for their immunosuppressive function. Long-term application of the sphingosine-1 phosphate receptor agonist FTY720 exerts pleiotropic anti-inflammatory effects, whereas short-term FTY720 boosts antiviral immunity. In this study, we provide evidence that FTY720 potently inhibits Treg proliferation in vitro and in vivo without affecting their viability, phenotype, or in vitro immunosuppression. In contrast, adoptively transferred Treg exposed ex vivo to FTY720 lost their protective effects in murine models of acute glomerulonephritis and acute graft-vs-host disease. On a cellular level, FTY720 inhibits IL-2-induced STAT-5 phosphorylation, paralleled by a loss of FoxP3 expression during Treg expansion in vitro. Notably, loss of in vivo immunosuppression is not due to impaired migration to or localization within secondary lymphoid organs. We could even show a selective trapping of adoptively transferred Treg in inflammatory lymph nodes by FTY720. Finally, Treg isolated from animals systemically exposed to FTY720 also exhibit a significantly impaired proliferative response upon restimulation when compared with Treg isolated from solvent-treated animals. In summary, our data suggest that sphingosine-1 phosphate receptor-mediated signals induced by FTY720 abrogate their in vivo immunosuppressive potential by blocking IL-2 induced expansion, which is indispensable for their in vivo immunosuppressive activity.
Improvement of Page Ranking Algorithm Based on Timestamp and Link (2008)

The traditional ranking algorithm favors the old pages, which makes old pages always appear on the top of the ranking results when pages are ranked according to the dynamic web by the static ranking algorithm. Therefore, this paper introduces temporal-link-analysis algorithm to resolve the problem. This algorithm uses the last modification time that returned by the HTTP response as the timestamp of nodes and links concerned. And the weight of the in-link and out-link are also integrated to compute the overall weight of the pages. Using the WTPR algorithm can make the old pages decline and new pages raise in the ranking result, meanwhile it can help the old pages which have high-quality get higher rank value than common old pages.
Absolute calibration for a broad range single shot electron spectrometer (2006)

This article gives a detailed description of a single shot electron spectrometer which was used to characterize electron beams produced by laser-plasma interaction. Contrary to conventional electron sources, electron beams from laser-plasma accelerators can produce a broad range of energies. Therefore, diagnosing these electron spectra requires specific attention and experimental development. Here, we provide an absolute calibration of the Lanex Kodak Fine screen on a laser-triggered radio frequency picosecond electron accelerator. The efficiency of scintillating screens irradiated by electron beams has never been investigated so far. This absolute calibration is then compared to charge measurements from an integrating current transformer for quasimonoenergetic electron spectra from laser-plasma interaction.
KARMA : A Secure Economic Framework for Peer-to-Peer Resource Sharing (2003)

Peer-to-peer systems are typically designed around the assumption that all peers will willingly contribute resources to a global pool. They thus suffer from freeloaders, that is, participants who consume many more resources than they contribute. In this paper, we propose a general economic framework for avoiding freeloaders in peer-to-peer systems. Our system works by keeping track of the resource consumption and resource contribution of each participant. The overall standing of each participant in the system is represented by a single scalar value, called their karma. A set of nodes, called a bank-set, keeps track of each node&apos;s karma, increasing it as resources are contributed, and decreasing it as they are consumed. Our framework is resistant to malicious attempts by the resource provider, consumer, and a fraction of the members of the bank set. We illustrate the application of this framework to a peer-to-peer filesharing application.
Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors (2020)

The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other lipids released from cells at the same time. An increasing volume of anecdotal reports and interest in the plant have provoked research into the activity of minor chemical constituents of the plant-including volatile terpenoids such as myrcene, α- and β- pinene, β-caryophyllene, and limonene. However, to date, no clear interaction has been identified. The current study was designed to determine whether terpenes in the cannabis plant have detectable receptor-mediated activity, or modify the activity of Δ<sup>9</sup>-tetrahydrocannabinol, cannabidiol, or the endocannabinoid 2-arachidonylglycerol at the cannabinoid receptors. In addition, we have utilized a standard radioligand binding paradigm with ability to detect orthosteric and allosteric interactions of test compounds. With the possible exception of a weak interaction of β-caryophyllene with CB2, no data were produced to support the hypothesis that any of the five terpenes tested (either alone or in mixtures) have direct interactions with CB1 or CB2, as the binding of radioligand ([<sup>3</sup>H]-CP55,940), Δ<sup>9</sup>-tetrahydrocannabinol, and cannabidiol were unaltered by the presence of terpenes. Similarly, terpene functional effects were also not detected, either alone or in combination with Δ<sup>9</sup>-tetrahydrocannabinol, cannabidiol, or 2-arachidonoylglycerol. This study adds to the evidence that the putative entourage effect cannot be explained by direct effects at CB1 or CB2.
Pulse-driven magnetostatic micro-actuator array based on ultrasoft elastomeric membranes for active surface applications (2012)

An array of pulse-driven magnetostatic micro-actuators with 2 mm pitch is proposed for highly deformable active surfaces. A wide range of applications can benefit from such devices, from droplet manipulation and active flow control to tactile display, for which this device was initially designed. This design ensures robustness, ease of fabrication and mass production compatibility. The device is composed of an array of 4 × 4 highly resistant elastomeric membranes achieved using microfabrication techniques. The magnetostatic actuation system is based on the interaction between a miniature coil and a SmCo micro-magnet. This mechanism was optimized by the finite-element method, leading to the introduction of different ferromagnetic circuits. Mechanical characterizations were achieved by laser interferometry. The micro-actuators can be used either in continuous mode or in pulse mode, allowing wide bandwidth, from dc to 1.5 kHz, and vibration amplitudes up to 150 μm for instantaneous forces of 30 mN. The device has good actuation homogeneity with ±20% amplitude variations between its actuators; low crosstalk (<5%) was also demonstrated. Finally, an improved actuation design benefiting from electroplated NiFe thin films is proposed and characterized, increasing performances (forces and displacements) by 50%.
Ethylene and Auxin in the Control of Wood Formation (2003)

This thesis considers aspects of the regulation of growth rate and fibre properties in forest trees. These properties are both genetically determined and influenced by environmental stimuli. Induction of reaction wood is an environmentally induced process involving changes in growth rate and fibre properties that can be readily studied. Plant hormones are signalling agents that play important roles in the initiation and coordination of wood formation; in this thesis the plant hormones auxin and ethylene were investigated using gas chromatography/mass spectrometry (GC/MS). A novel MS technique for measuring the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) in minute amounts of plant tissue was developed. Ethylene is often connected to stress responses in plants, and ethylene evolution is increased when reaction wood is formed. Here it is demonstrated that this increase is regulated by ACC oxidase, the enzyme catalysing the last step in the ethylene biosynthetic pathway. This is in contrast to most of the earlier findings that tended to indicate that ethylene production directly reflects the availability of ACC. Although ethylene is strongly up-regulated during reaction wood formation, its role in modulating the growth rate and fibre properties remains unknown. Further, it is demonstrated that reaction wood in both poplar (Populus tremula L.) and pine (Pinus sylvestris L.) is formed without changes in auxin concentration in the cambial tissues. This suggests that the previously held assumption that the difference in auxin concentration is key factor in the induction of reaction wood is unsound. Further, auxin concentrations were compared in hybrid aspen trees (Populus tremula L. x tremuloides Michx.) growing vertically at different growth rates. These trees showed good correlations between auxin levels and growth rates. The growth rate was mediated by increases in the cell cycling rate rather than in the width of the cell division zone. Thus, the growth rate in poplar was correlated to auxin levels in normal wood formation, but not during reaction wood formation.
Novel Bismuth-Based Inorganic Oxide Waste Forms for Iodine Storage. (2009)

Abstract not provided.
Management of Mild Aortic Stenosis During Coronary Artery Bypass Surgery: (2003)

The OM of reoperative AVR following CABG has fallen in recent years. Given the relevance of newer techniques and approaches, it may be reasonable to adopt an expectant management approach in patients with asymptomatic mild-to-moderate AS (i.e., mean systolic gradient less than 25 mmHg) at the time of CABG.
The performance limit of coherent OTDR enhanced with optical fiber amplifiers due to optical nonlinear phenomena (1994)

This paper theoretically and experimentally clarifies the limit of incident optical pulse power in coherent optical time-domain reflectometry (C-OTDR) enhanced with optical fiber amplifiers. The critical pulse power, at which the performance of C-OTDR is degraded by the effect of optical nonlinear phenomena in a single-mode optical fiber, depends on the amplified optical pulse waveform and the pulse width. For a pulse width of 1 /spl mu/s or longer, the incident pulse power is limited by the effect of self-phase modulation (SPM). When an optical pulse having a power gradient within the pulse width is incident to a single-mode optical fiber, the optical frequency of the backscattered signal is shifted by SPM, and the center frequency of the signal moves outside the receiver band, so the sensitivity of C-OTDR is degraded. For a pulse width of 100 ns, the incident optical pulse power is limited by four-wave mixing (FWM) which transfers the energy from the incident optical pulse to Stokes and anti-Stokes light as a result of the interaction between the incident optical pulse and amplified spontaneous emission. This paper also demonstrates the high performance of C-OTDR enhanced with EDF A's with 48, 44, 39, and 29 dB single-way dynamic ranges for pulse widths of 10 /spl mu/s, 4 /spl mu/s, 1 /spl mu/s, and 100 ns, respectively, limited by the effect of SPM or FWM. These results are believed to be the best performance of C-OTDR with EDFA's.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nonlinear Robust Industrial Robot Control (1989)

A new nonlinear robot control scheme is proposed in this paper which is robust against modeling errors and unknown disturbance. The control input consists of a nonlinear part and a linear part. The nonlinear part decouples robot dynamics to obtain a set of equations in terms of each joint’s input and output; the linear part applies robust servomechanism theory to suppress effects of modeling error and unknown disturbance. The nonlinear part can be calculated by using recursive Newton-Euler formulas or parallel processing hardware, and the linear part by dedicated, localized microprocessors. Therefore, this methodology is computationally efficient, and is applicable to general robot configuration. The scheme is applied to control a two-joint, SCARA-type robot. The simulation results demonstrate that this scheme can achieve fast and precise robot motion control under substantial modeling errors.
Design for a BlackLight Power multi-cell thermally coupled reactor based on hydrogen catalyst systems (2011)

The design and cost estimates compared with other systems of an energy-producing reactor system are presented. Heat from hydrino reactions within individual cells provides both the reactor power and the heat for regeneration of the reactants. These processes occur continuously over a plurality of cells in different phases of the processes. The hydrino reactions are maintained and regenerated in a batch mode using thermally coupled multi-cells arranged in bundles wherein cells in the power-production phase of the cycle heat cells in the regeneration phase. In this intermittent cell power design, the thermal power is statistically constant as the cell number becomes large, or the cell cycle is controlled to achieve steady power. The conversion of thermal power to electrical power requires the use of a heat engine exploiting a cycle such as a Rankine, Brayton, Stirling, or steam-engine cycle (Int. J. Energy Res. 1997; 21:113–127; Int. J. Energy Res. 1998; 22:237–248; Int. J. Energy Res. 1998; 22:991–1000; Int. J. Energy Res. 2010; 34:1071–1087; Int. J. Energy Res. 2009; 33:1203–1232). Owing to the temperatures, economy goal, and efficiency, the Rankine cycle is the most practical and can produce electricity from a steam source at 30–40% efficiency with a component capital cost of about $300 per kW electric. Conservatively, assuming a conversion efficiency of 25%, the total cost with the addition of the boiler and chemical components is estimated at $1380 per kW electric. The system applications for distributed power (1–10 MW electric) and central generation retrofit and green-field projects are projected to be very competitive relative to existing power sources and systems. Copyright © 2011 John Wiley & Sons, Ltd.
Studies on the Foaming Property of the Chicken Egg White (1964)

When ovomucin (B) was added to the egg white, its foam stability was greatly increased although its foaming power was decreased a little. On the other hand, other proteins of the egg white had little effect on the foam stability of the egg white. The solution of ovomucin (B) was highly viscous and other highly viscous solutions gave almost the same effect on the foaminess of the egg white as that of ovomucin (B). From these results, discussions were made about the role of ovomucin (B) in the foaminess of the egg white.
HTS Shim Coils Energized by a Flux Pump for the MIT 1.3-GHz LTS/HTS NMR Magnet: Design, Construction, and Results of a Proof-of-Concept Prototype (2018)

In this paper we present design, construction, and preliminary results of a proof-of-concept prototype of high-temperature superconductor (HTS) shim coils operated at 77 K and energized, for the first time among all shim coils, by a flux pump, here called digital flux injector (DFI). Although the prototype shims were wound with 2-mm wide REBCO tape, and DFI with Bi2223 and REBCO tapes, the HTS Z1 and Z2 shims to be installed in the MIT 1.3-GHz LTS/HTS NMR magnet (1.3G) currently under construction and operated at 4.2 K will be wound with reinforced Bi2212 wire and DFI with Nb<sub>3</sub>Sn tape. The paper concludes with two sets of Bi2212 Z1 and Z2 shims for 1.3G.
Optimization of Power Management Strategies for a Hydraulic Hybrid Medium Truck (2002)

This paper investigates development of power management strategies tailored specifically to a medium truck with parallel hydraulic hybrid powertrain. The hydraulic hybrid vehicle (HHV) system is modeled in MATLAB/SIMULINK environment. As the starting point, this study considers rule-based power management strategy adopted from the previous HEV study. Dynamic Programming (DP) algorithm is used to find the optimal trajectories for gear shifting and engine/motor power splitting, assuming that the federal urban driving schedule represents typical use of a delivery truck. Implementable rules are derived from analyzing the optimal trajectories, and it is shown that the changes are to a large extent driven by high power density and low energy density of the hydraulic propulsion system. System behavior demonstrates effectiveness of new strategies in further improving the fuel economy of the hydraulic hybrid truck.
Design and realization of a modular architecture for textual entailment (2013)

Abstract A key challenge at the core of many Natural Language Processing (NLP) tasks is the ability to determine which conclusions can be inferred from a given natural language text. This problem, called the Recognition of Textual Entailment (RTE) , has initiated the development of a range of algorithms, methods, and technologies. Unfortunately, research on Textual Entailment (TE), like semantics research more generally, is fragmented into studies focussing on various aspects of semantics such as world knowledge, lexical and syntactic relations, or more specialized kinds of inference. This fragmentation has problematic practical consequences. Notably, interoperability among the existing RTE systems is poor, and reuse of resources and algorithms is mostly infeasible. This also makes systematic evaluations very difficult to carry out. Finally, textual entailment presents a wide array of approaches to potential end users with little guidance on which to pick. Our contribution to this situation is the novel EXCITEMENT architecture, which was developed to enable and encourage the consolidation of methods and resources in the textual entailment area. It decomposes RTE into components with strongly typed interfaces. We specify (a) a modular linguistic analysis pipeline and (b) a decomposition of the ‘core’ RTE methods into top-level algorithms and subcomponents. We identify four major subcomponent types, including knowledge bases and alignment methods. The architecture was developed with a focus on generality, supporting all major approaches to RTE and encouraging language independence. We illustrate the feasibility of the architecture by constructing mappings of major existing systems onto the architecture. The practical implementation of this architecture forms the EXCITEMENT open platform. It is a suite of textual entailment algorithms and components which contains the three systems named above, including linguistic-analysis pipelines for three languages (English, German, and Italian), and comprises a number of linguistic resources. By addressing the problems outlined above, the platform provides a comprehensive and flexible basis for research and experimentation in textual entailment and is available as open source software under the GNU General Public License.