gebhart/patrepeval huggingface dataset:
Metabolically active microbial communities in marine sediment under high-CO2 and low-pH extremes (2012)

Sediment-hosting hydrothermal systems in the Okinawa Trough maintain a large amount of liquid, supercritical and hydrate phases of CO(2) in the seabed. The emission of CO(2) may critically impact the geochemical, geophysical and ecological characteristics of the deep-sea sedimentary environment. So far it remains unclear whether microbial communities that have been detected in such high-CO(2) and low-pH habitats are metabolically active, and if so, what the biogeochemical and ecological consequences for the environment are. In this study, RNA-based molecular approaches and radioactive tracer-based respiration rate assays were combined to study the density, diversity and metabolic activity of microbial communities in CO(2)-seep sediment at the Yonaguni Knoll IV hydrothermal field of the southern Okinawa Trough. In general, the number of microbes decreased sharply with increasing sediment depth and CO(2) concentration. Phylogenetic analyses of community structure using reverse-transcribed 16S ribosomal RNA showed that the active microbial community became less diverse with increasing sediment depth and CO(2) concentration, indicating that microbial activity and community structure are sensitive to CO(2) venting. Analyses of RNA-based pyrosequences and catalyzed reporter deposition-fluorescence in situ hybridization data revealed that members of the SEEP-SRB2 group within the Deltaproteobacteria and anaerobic methanotrophic archaea (ANME-2a and -2c) were confined to the top seafloor, and active archaea were not detected in deeper sediments (13-30 cm in depth) characterized by high CO(2). Measurement of the potential sulfate reduction rate at pH conditions of 3-9 with and without methane in the headspace indicated that acidophilic sulfate reduction possibly occurs in the presence of methane, even at very low pH of 3. These results suggest that some members of the anaerobic methanotrophs and sulfate reducers can adapt to the CO(2)-seep sedimentary environment; however, CO(2) and pH in the deep-sea sediment were found to severely impact the activity and structure of the microbial community.
Low-melting nematic V-shaped 1,3,4-thiadiazoles – phase engineering using small substituents and mixtures of flexible chains (2011)

V-shaped, shape-persistent molecules with a central 1,3,4-thiadiazole core and a bending angle of 160° have been synthesised and their thermotropic behaviour characterised by means of polarised optical microscopy, differential scanning calorimetry and X-ray diffraction. The V-shaped mesogens and the intermediate hockey-stick compounds exhibited enantiotropic nematic phases. The influence of fluorine or methyl substituents in the terminal phenyl rings, and alkyl chains in place of chains terminating with ethyl esters, has been studied in order to obtain structural information related to the stabilisation of the nematic phases.
Naphthoquinone antimalarials; metabolic oxidation products. (1948)

A study of the metabolism of nineteen 2-hydroxy-3-alkyl-1,4-naphthoquinones in human subjects has established that these substances suffer rapid and extensive degradation consisting in oxidation of the hydrocarbon side chain with the production of metabolites that are distinctly more hydrophilic than the compounds administered. Several of the metabolites were isolated and fully identified; they are secondary alcohols, tertiary alcohols, or carboxylic acids.
Experimental Validation of Model Updating and Damage Detection via Eigenvalue Sensitivity Methods with Artificial Boundary Conditions (2017)

The use of finite element modeling (FEM) in design has expanded as computers have become more capable. Despite these advancements, the construction of physical prototypes remains an essential aspect of design and testing. FEM limitations include the inability to accurately account for joints, damping, and geometric complexities. Due to the reality gap between a FEM and the prototype, there may be design deficiencies that cannot be identified until the prototype is tested. Using eigenvalue sensitivities, enhanced by artificial boundary conditions (ABC), the gap between simulation and reality can be closed via FEM updating. With an updated FEM, the same eigenvalue sensitivities can be utilized to detect damage in structural systems in use. Damage that produces differences in natural frequencies between the structure and its FEM can be related to the loss in flexural rigidity, as it is usually assumed that mass modeling is correct. This indicator allows adjustment of a FEM to match a prototype or to detect damage in a potentially compromised structure via comparison to an updated FEM. Based on simulation, a combination of multiple pin and spring ABCs is optimal for producing an ideal sensitivity matrix, and thus, ideal damage detection capability. However, in the experimental realm, the synthesis transformation used to apply ABCs to the measured frequency response functions can distort the frequency response function peaks, leading to error. A compromise of a single pin ABC permits both effective model updating and damage detection.
Pharmacology and therapeutic uses of cat’s claw (2009)

Cat’s claw, also known as the “life-giving vine of Peru,” “saventaro,” or “uña de gato,” is a thick woody vine indigenous to the Amazon rain forest and other tropical areas of South and Central America.1 It has been used as a sacred plant of healing for over 2000 years. The plant, described by its Spanish folk name “uña de gato,” has a hooklike thorn that grows largely along the vine in a leafy pattern that resembles the claws of a cat.1 There are several species of cat’s claw, but the two most common species used and marketed interchangeably for their various properties are Uncaria tomentosa and Uncaria guianensis.2,3U. tomentosa, evidently the preferred species because of its higher alkaloid content and the ease of standardization, is the focus of this article. U. tomentosa may be contaminated with other Uncaria species, including Uncaria rhynchophylla, which has been used in Chinese herbal preparations. In some European countries (e.g., Germany, Austria), cat’s claw can only be dispensed with a prescription. Currently, cat’s claw is widely used and is one of the top herbal remedies sold in the United States, despite a lack of high-quality human evidence supporting its benefits. Its popularity in the alternative medicine market might be partly because of its proposed abilities to strengthen the immune system, inhibit inflammation, inhibit tumor growth, and suppress viral replication.4 Despite the alleged medical benefits associated with cat’s claw use, relatively few scientific studies have been conducted to establish the safety and efficacy of this plant.
Interaction of N-WASP with hnRNPK and Its Role in Filopodia Formation and Cell Spreading (2006)

N-WASP is a member of the WASP family of proteins, which play essential roles in actin dynamics during cell adhesion and migration. hnRNPK is a member of the heterogeneous nuclear ribonucleoprotein complex, which has also been implicated in the regulation of cell spreading. Here, we identify a direct interaction between N-WASP and hnRNPK. We show that this interaction is mediated by the N-terminal WH1 domain of N-WASP and the segment of hnRNPK containing its K interaction (KI) domain. Furthermore, these two proteins are co-localized at the cell periphery in the spreading initiation center during the early stage of cell spreading. We found that co-expression of hnRNPK with N-WASP reverses the stimulation of cell spreading by N-WASP, and this effect is correlated with hnRNPK binding to N-WASP. Expression of hnRNPK does not affect subcellular localization of N-WASP protein. However, co-expression of hnRNPK with N-WASP reduced filopodia formation stimulated by N-WASP in spreading cells. Together, these results identify hnRNPK as a new negative regulator of N-WASP and suggest that hnRNPK may regulate the initial stage of cell spreading by direct association with N-WASP in the spreading initiation center.
A Study of Cytochrome c Oxidase in Lipid Bilayer Membranes on Electrode Surfaces (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Study of Cytochrome c Oxidase in Lipid Bilayer Membranes on Electrode SurfacesJohn K. Cullison, Fred M. Hawkridge, Naotoshi Nakashima, and Shimichi YoshikawaCite this: Langmuir 1994, 10, 3, 877–882Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/la00015a044https://doi.org/10.1021/la00015a044research-articleACS PublicationsRequest reuse permissionsArticle Views283Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Odorant-binding proteins in vertebrates and insects: similarities and possible common function (1990)

Journal Article Odorant-binding proteins in vertebrates and insects: similarities and possible common function Get access Paolo Pelosi, Paolo Pelosi Istituto di Industrie Agrarie, Universita' di Pisavia S. Michele, 4, 56100 Pisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosario Maida Rosario Maida Istituto di Industrie Agrarie, Universita' di Pisavia S. Michele, 4, 56100 Pisa, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Chemical Senses, Volume 15, Issue 2, April 1990, Pages 205–215, https://doi.org/10.1093/chemse/15.2.205 Published: 01 April 1990
Audio to audio-video speech conversion with the help of phonetic knowledge integration (2002)

The paper describes a new approach for the creation of natural audio-video speech signals from an acoustic speech signal or a text input. Two applications are at hand: an intelligent audio-video telephone terminal and a training aid for learning lip-reading.
Variant von Willebrand's Disease (1980)

We have examined the multimeric composition of factor VIII/von Willebrand factor in plasma and platelet lysates by means of sodium dodecyl sulfate agarose electrophoresis followed by staining with (125)I-labeled affinity-purified antibody. In normal plasma and platelet lysates, factor VIII/von Willebrand factor displayed 10 distinct multimers that ranged in apparent molecular weight from 0.86 to 9.9 x 10(6). The molecular weight difference between adjacent bands was 0.8-1.1 x 10(6). Larger material, not resolved into discrete bands, was also present with an average M(r) of 14.5 x 10(6). Though the dimer (apparent M(r) = 0.48 x 10(6)) and the monomer (apparent M(r) = 0.28 x 10(6)) generated by reduction of disulfide bonds were readily identified in this system, they were not detected in normal plasma or platelets. No differences were observed between fresh plasma prepared without anticoagulant and fresh or frozen plasma anticoagulated with either citrate or heparin. "Variant" (type II) von Willebrand's disease could be divided into two subtypes. In subtype IIA, factor VIII/von Willebrand factor in plasma consisted predominantly of the five smaller multimers with traces of the sixth and seventh (M(r) up to 4.5 x 10(6)). In subtype IIB, all these multimers were easily detected and, in addition, bands of intermediate size (M(r) = 8.5 x 10(6) and smaller) were present. In contrast, the multimeric composition of IIB platelet factor VIII/von Willebrand factor was identical to normal, whereas in subtype IIA the larger multimers were absent from platelets as well as from plasma. In subtype IIB, binding of factor VIII/von Willebrand factor to platelets occurred at lower concentrations of ristocetin than required for normal and multimers of smaller size than in normal bound. On the contrary, in subtype IIA, binding was minimal, as was true of normal factor VIII/von Willebrand factor of equivalent size. Thus, physical as well as functional differences in the two subtypes of variant von Willebrand's disease described suggest that different pathogenetic mechanisms underlie the factor VIII/von Willebrand factor abnormalities in these patients.
Nitrogen bridgehead compounds. Part <b>85</b>. Synthesis and reactivity of 3,4‐dihydro‐1<i>H</i>,6<i>H</i>[1,4]oxazino[3,4‐<i>b</i>]quinazolin‐6‐ones (1993)

Abstract 3,4‐Dihydro‐1 H ,6 H ‐[1,4]oxazino[3,4‐ b ]quinazolin‐6‐one 3 and its 1‐methyl and 1‐hydroxy derivatives 8 and 13 were prepared by different routes. The active methylene group of compound 3 was reacted with electro‐hilic reagents (bromine, phenyldiazonium chloride, nitrous acid, a Vielsmeier‐Haack reagent, aromatic aldehydes and diethyl oxalate) to yield 1‐substituted‐3,4‐dihydro[1 H ,6 H )‐1,4‐oxazino[3,4‐ b ]quinazo‐lin‐6‐ones. The reactivity of 1‐hydroxy and 1‐bromo derivatives 13 and 15 were also investigated in some reactions. The 3,4‐dihydro‐l H ,6 H ‐[1,4]oxazino[3,4‐ b ]quinazolin‐6‐ones were characterized by means of uv, 1 H and 13 C nmr spectroscopy.
III International IUPAC Symposium on marine natural products: a survey (1981)

info:eu-repo/semantics/published
[Obstetrical study of the pelvis: a historical overview]. (1995)

The female pelvis is fundamental to life itself, but it took ages to grasp this truism. During Antiquity, physicians had no need for the concepts of pelvic dystocia and cephalopelvic disproportion. When Aranzo (16th century), a practising physician, stated that a disproportion between the size of the fetus and that of the bony pelvis was the main culprit of difficult labor, his suggestion was overlooked, so much so that it was Hendrik van Deventer (1701) who came to be coined "father of the pelvic theory". The need for an accurate knowledge of the dimensions of the maternal pelvis and of the fetal skull became imperative in the middle of the 18th century, when forceps extraction had become popular. Levret, but above all William Smellie, made valuable contributions to the pelvic theory, which, however, were weakened by Baudelocque's fallacies concerning the intrinsic value of external pelvimetry. After the first quarter of the 19th century, the epicenter of scientific obstetrics moved to Germany and Austria, and German-speaking practitioners, e.g. Michaelis, Litzmann, and the Naegele, deepened our insight in the mechanism of labor. After the discovery of the X-rays (1895), the use of instrumental pelvimetry declined, but the clinical breakthrough of radiopelvimetry was delayed until the twenties of this century. Radiopelvimetry, a very valuable technique indeed, dispensed a large number of mothers from undergoing abdominal delivery. However, awareness of the hazards of fetal-maternal exposure to ionizing radiation pushed ante- and intrapartum radiopelvimetry from the scene. Thanks to the progress of chemistry, pharmacology and electronics, "dynamic pelvimetry" became the fad, heralded by what is called "active management of labour". The fetus now assumed the role of "dynamic pelvimeter". The historical circle was closed.
Student Evaluations of Teaching and the Cognitive Level of Economics Courses (1977)

The Journal of Economic Education of Fall 1973 was devoted to the subject of student evaluations of teachers. That issue has engendered a great many papers, only a few of which can be published in the JEE because of space limitations. Michael Everett's report is not a mere replication of previous research on the subject, but adds a new dimension—the possible effect of student evaluations on the cognitive level of college economics courses. His finding that students may favor professors who emphasize lower level cognitive material will surely be distressing to many teachers, and should cause sober reflection on the part of administrators and others involved in establishing faculty evaluation procedures and policies.
Photon Mass and New Experimental Results on Longitudinal Displacements of Laser Beams near Total Reflection (1972)

The suggestion of de Broglie and Vigier that an "intermediate shift" might be expected to be obtained in the Goos-Hanchen effect, for plane polarized beams having components both parallel and perpendicular to the plane of incidence of the totally reflective surface, is shown to be untenable. Their quoted experimental results are adequately explained classically.
Regulation of the <i>ansB</i> gene of <i>Salmonella enterica</i> (1993)

The expression of L-asparaginase II (encoded by ansB) in Salmonella enterica was found to be positively regulated by the cAMP receptor protein (CRP) and anaerobiosis. The anaerobic regulation of the S. enterica ansB gene is not mediated by the anaerobic transcriptional activator FNR. This is unlike the situation of the ansB gene of Escherichia coli, which is dependent on both CRP and FNR. To investigate this fundamental difference in the regulation of L-asparaginase II expression in S. enterica, the ansB gene was cloned and the nucleotide sequence of the promoter region determined. Sequence analysis and transcript mapping of the 5' promoter region revealed a single transcriptional start point (tsp) and two regulatory sites with substantial homology with those found in E. coli. One site, centred -90.5 bp from the tsp, is homologous to a hybrid CRP/FNR ('CF') site which is the site of CRP regulation in the E. coli promoter. The other site, centred 40.5 bp upstream of the tsp, is homologous to the FNR binding site of the E. coli promoter. Significantly, however, a single base-pair difference exists in this site, at a position of the related CRP and FNR DNA-binding site consensus sequences known to be involved in CRP versus FNR specificity. Site-directed mutagenesis indicates that this single difference, relative to the homologous E. coli site, results in a CRP binding site and the observed FNR-independent ansB expression in S. enterica.(ABSTRACT TRUNCATED AT 250 WORDS)
Adrenal Autoantibodies Bind to Adrenal Subcellular Fractions Enriched in Cytochrome-c Reductase and 5′-Nucleotidase (1990)

A quantitative assay for human adrenal autoantibodies has been developed to aid in the detection and isolation of human adrenal antigens. To define the subcellular location(s) of the antigen(s) capable of binding with these antibodies, we have quantitated both antibody binding to various adrenal subcellular fractions and the adrenal autoantibody binding inhibition caused by each subcellular fraction. To further define the subcellular location of the autoantibody binding, each fraction was assayed for organelle-specific marker enzyme activities. Enzyme activities were correlated to adrenal autoantibody binding to each fraction by linear regression. Of the materials tested, both antibody binding and inhibition of binding were most highly correlated with adrenal subcellular fractions enriched with cytochrome-c reductase and 5'-nucleotidase (r = 0.98; P less than 0.05). Thus, our data support the localization of adrenal autoantigen(s) in the microsomes, plasma membrane, or both.
Microstructural modification of aluminum-silicon alloy powders during dynamic consolidation (1982)

We describe the preliminary results of a study of the dynamic consolidation of a rapidly solidified aluminum-6% silicon alloy powder. The microstructure of this alloy, consisting of a dispersion of silicon precipitates at the boundaries of essentially pure aluminum grains, provides an excellent grid against which to observe the changes induced by shock compaction. Examination of recovered specimens, shocked with either explosives or high velocity projectiles, shows that at low stress, high density is achieved without substantial interparticle bonding, and the microstructure is essentially that of the starting powder. For stresses between 1.7 and 2.6 GPa we observe increasing compact integrity, and the appearance of regions of altered microstrucure at the interfaces between powder particles. Above 4.0 GPa, such modified material is a distinctive feature of the microstructure, and compacts are well bonded. Increasing the stress serves not so much to increase the density as to increase the amount of energy deposited in the specimen. Bonding is the result of the local deposition of energy at particle interfaces during the passage of the shock. This energy may be calculated from the measured Hugoniot (shock compression) curve of the powder. It is suggested that through proper choice of stress level, structurallymore » sound compacts can be formed with limited modification of the powder microstructure. 7 figures.« less
Smooth handover by synchronizing context transfer protocol and fast mobile IPv6 (2009)

As the Internet continues to shape and reshape our lives, there is a parallel phenomenon taking place in wireless communication which is equally influential. Mobile communication has proved to be a major paradigm in the history of human communication. As both the Internet and mobile telephony continue their dramatic advances, there is a lot of requirement that should be available such as valid IP address. To provide seamless communications for such networks, Fast Mobile IPv6 (FMIPv6) has been proposed. In this paper, to Improve Mobile IPv6 Handover Latency two new schemes has proposed, Predictive and Reactive, for negotiating session parameters and reserve resources synchronize with the fast handover procedure simultaneously to reduce the signaling cost. The performances of the proposed mechanisms are evaluated by analysis.
Rheological Behavior of Glucosamine and Glucosamine Hydrochloride Suspensions under DC Electric Field (2007)

The electrorheological behavior of the glucosamine and glucosamine hydrochloride suspensions was investigated. The the glucosamine suspension behaved as a Newtonian fluid due to low conductivity even though it has polar group. The glucosamine hydrochloride suspension behaved as a Nonnewtonian fluid under the application of the electric field .The shear stress of the glucosamine hydrochloride suspension is proportional to 1.86 power of the electric field. The value of the structure factor, A, was 1 and it may be resulted due to the formation of single chain upon application of the electric field.
The lymphatics of the greater omentum. An experimental study in the dog. (1969)

No detailed description of the lymphatics of the greater omentum has hitherto been presented. In an earlier, preliminary study on dogs (lntonti, Nylander  and  Tjernberg, 1964) we found the peripheral parts of the omentum to be relatively richly supplied with lymph vessels of very fine calibre. These marginal lymphatics formed a delicate net-like pattern. Local bulges indicated the presence of valves in the collecting lymph channels which increased surprisingly little in calibre in their course towards the base of the omentum. We suggested that these lymph channels might be responsible for the peritoneal drainage to a considerable extent. In the present investigation we have further studied the lymphatics of the omentum and their connections with the lymph vessels of neighbouring organs, especially the stomach and the spleen. The study of these topographical relations was initiated by the well-known fact that the greater omentum is very often the seat of metastases from abdominal and pelvic carcinoma.