gebhart/patrepeval huggingface dataset:
Dynamic changes in the zone of apposition and diaphragm length during maximal respiratory efforts. (1994)

BACKGROUND--Clinical tests of diaphragmatic strength are limited by the wide normal variation in maximal pressure which result, in part, from changes in diaphragmatic length. During relaxation at different lung volumes diaphragmatic length (LDI) can be estimated from the length of the zone of apposition (LZapp) and the transverse diameter of the rib cage (DRC). A study was carried out in two subjects using sequential digital radiography at six frames/second to determine whether these relations apply during maximal respiratory efforts which distort the rib cage and diaphragm. METHODS--The length of the anteroposterior contour of the diaphragm and DRC were determined by curve fitting. LZapp was measured with a millimetre rule. RESULTS--A significant correlation was found between LDI and LZapp during both maximal inspiratory and expulsive manoeuvres (R2 = 0.88 and 0.52). LDI was estimated from the measurements of LZapp and DRC using a multiple regression equation derived from measurements during static relaxation. Despite the complex dynamic events at the onset of these "static" manoeuvres, actual LDI correlated strongly with derived LDI using all data for the two manoeuvres in each subject (R2 = 0.95 and 0.84). Measurements with ultrasonography (12 cm linear probe) and magnetometers confirmed the changes in LZapp and DRC during inspiratory and expulsive efforts. CONCLUSIONS--Non-invasive measurements of LZapp and DRC can be used to derive an accurate estimate of diaphragmatic length under dynamic conditions.
Compression-based Image Registration (2006)

Image registration is an important component of image analysis used to align two or more images. In this paper, we present a new framework for image registration based on compression. The basic idea underlying our approach is the conjecture that two images are correctly registered when we can maximally compress one image given the information in the other. The contribution of this paper is twofold. First, we show that the image registration process can be dealt with from the perspective of a compression problem. Second, we demonstrate that the similarity metric, introduced by Li et al., performs well in image registration. Two different versions of the similarity metric have been used: the Kolmogorov version, computed using standard real-world compressors, and the Shannon version, calculated from an estimation of the entropy rate of the images
Catalytic Studies in Electrochemical Membrane Reactors (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Scheduling Precedence Graphs in Systems with Interprocessor Communication Times (1989)

The problem of nonpreemptively scheduling a set of m partially ordered tasks on n identical processors subject to interprocessor communication delays is studied in an effort to minimize the makespan. A new heuristic, called earliest task first (ETF), is designed and analyzed. An algorithm is also provided to calculate the communication requirements over some immediate predecessor-immediate successor pairs along one chain. The time complexity of Algorithm ETF is O(nm<sup>2</sup>).
Anger or Compromise? Adolescents' Conflict Resolution Strategies in Relation to Gender and Type of Peer Relationship (2006)

ABSTRACT This study examined gender differences in conflict resolution across three types of adolescent peer relationship. We predicted that adolescents would vary in their use of overt anger and compromise in accord with gender stereotypes, depending on the type of peer relationship under consideration. It was predicted that, in conflicts with opposite-gender friends, adolescents would modify the strategies typically used with same-gender friends to more closely match those of the opposite gender. Furthermore, it was predicted that, in romantic relationships, compared with cross-gender friendships, adolescents would use more compromise and less overt anger. Broad support for these propositions was found, the main exception being girls' greater use of overt anger than expected, in all three types of peer relationships. Possible reasons posited were changing male and female roles in society and the use of overt anger questionnaire items that reflect social aggression. It was concluded that efforts to promote constructive conflict resolution by adolescents should consider reasons why young people choose different conflict resolution strategies in different types of peer relationships.
Cognitive Change, Medical Illness, and Crash Risk Among Older Drivers (1997)

This paper reviews selected issues concerning the natural history of cognitive change among older persons and whether the potential effects of such change on the safe operation of a motor vehicle can detected prior to the occurrence of an adverse outcome, such as a crash. Data are reviewed from selected recent, large, population-referent epidemiological studies that have sought direct associations between medical conditions of their treatments and crash risk. Several important medical risk factors have been identified and, if confirmed, these factors must be considered along with the assessment of cognitive decline and dementia when evaluating safety issues in older drivers.
Prodrugs of Fluoro-Substituted Benzoates of EGC as Tumor Cellular Proteasome Inhibitors and Apoptosis Inducers (2008)

The most potent catechin in green tea is (-)-epigallocatechin-3-gallate [(-)-EGCG], which, however, is unstable under physiological conditions. To discover more stable and more potent polyphenol proteasome inhibitors, we synthesized several novel fluoro-substituted (-)-EGCG analogs, named F-EGCG analogs, as well as their prodrug forms with all of -OH groups protected by acetate. We report that the prodrug form of one F-EGCG analog exhibited greater potency than the previously reported peracetate of (-)-EGCG to inhibit proteasomal activity, suppress cell proliferation, and induce apoptosis in human leukemia Jurkat T cells, demonstrating the potential of these compounds to be developed into novel anti-cancer and cancer-preventive agents.
A novel bidirectional multilevel boost-buck dc-dc converter (2009)

A novel noninverting boost-buck dc-dc converter topology is presented, applicable when both sides of the converter need to have the same grounding. It is based on the back-to-back connection of two n-level diode-clamped converter legs, and allows bidirectional power flow. A simplified topology is proposed for unidirectional power flow applications. Two new pulse width modulation strategies with different advantages are proposed to operate the converter guaranteeing dc-link capacitor voltage balance in every switching cycle for all possible operating conditions and using small capacitance values. The semiconductor device losses are analytically compared to the losses in a conventional two-level boost-buck converter. The analysis yields a higher efficiency for the multilevel converter, especially as the number of levels increases. Experimental results are presented to validate the good converter performance in a five-level converter prototype.
Wavelength-scanning surface plasmon resonance imaging (2005)

A new surface plasmon resonance (SPR) imaging technique was proposed. After measurements were conducted at varying wavelengths, the wavelength affording the minimum brightness (SPR wavelength) was determined at each pixel of the image. A two-dimensional map of the SPR wavelength could be converted to a thickness profile by use of a nonlinear calibration curve, which was obtained by Fresnel calculation. An array of protein thin layers on a gold film was evaluated in air to present the layers' surface structure in nanometer scale.
Auto-tuning a high-level language targeted to GPU codes (2012)

Determining the best set of optimizations to apply to a kernel to be executed on the graphics processing unit (GPU) is a challenging problem. There are large sets of possible optimization configurations that can be applied, and many applications have multiple kernels. Each kernel may require a specific configuration to achieve the best performance, and moving an application to new hardware often requires a new optimization configuration for each kernel. In this work, we apply optimizations to GPU code using HMPP, a high-level directive-based language and source-to-source compiler that can generate CUDA / OpenCL code. However, programming with high-level languages may mean a loss of performance compared to using low-level languages. Our work shows that it is possible to improve the performance of a high-level language by using auto-tuning. We perform auto-tuning on a large optimization space on GPU kernels, focusing on loop permutation, loop unrolling, tiling, and specifying which loop(s) to parallelize, and show results on convolution kernels, codes in the PolyBench suite, and an implementation of belief propagation for stereo vision. The results show that our auto-tuned HMPP-generated implementations are significantly faster than the default HMPP implementation and can meet or exceed the performance of manually coded CUDA / OpenCL implementations.
miRNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways (2010)

Micro RNAs (miRNA) negatively regulate protein-coding genes at the posttranscriptional level and are critical in tumorigenesis. Schwannomas develop from proliferation of dedifferentiated Schwann cells, which normally wrap nerve fibers to help support and insulate nerves. In this study, we carried out high-throughput miRNA expression profiling of human vestibular schwannomas by using an array representing 407 known miRNAs to explore the role of miRNAs in tumor growth. Twelve miRNAs were found to be significantly deregulated in tumor samples as compared with control nerve tissue, defining a schwannoma-typical signature. Among these miRNAs, we focused on miR-7, which was one of the most downregulated in these tumors and has several known oncogene targets, including mRNAs for epidermal growth factor receptor (EGFR) and p21-activated kinase 1 (Pak1). We found that overexpression of miR-7 inhibited schwannoma cell growth both in culture and in xenograft tumor models in vivo, which correlated with downregulation of these signaling pathways. Furthermore, we identified a novel direct target of miR-7, the mRNA for associated cdc42 kinase 1 (Ack1), with the expression levels of miR-7 and Ack1 being inversely correlated in human schwannoma samples. These results represent the first miRNA profiling of schwannomas and the first report of a tumor suppressor function for miR-7 in these tumors that is mediated by targeting the EGFR, Pak1, and Ack1 oncogenes. Our findings suggest miR-7 as a potential therapeutic molecule for schwannoma treatment, and they prompt clinical evaluation of drugs that can inhibit the EGFR, Pak1, and Ack1 signaling pathways to treat this tumor type.
New mouse 5‐HT2‐like receptor Expression in brain, heart and intestine (1992)

A novel member of the family of G protein-coupled receptors has been isolated from a mouse brain cDNA library by screening with polymerase chain reaction (PCR) generated fragment of mouse genomic DNA amplified using degenerated primers. Sequence comparison demonstrates that the encoded protein sequence shows the highest homology to the 5-HT2 family of receptors. The pharmacological profile of membranes from COS cells transfected with this cDNA, corresponds to a new 5-HT2-like receptor that we propose to call 5-HT2C. Its major sites of expression are in the mouse intestine and heart, also with detectable expression in brain and kidney. We speculate that it could account at least in part for the 'atypical' functions attributed to the 5-HT1C/5-HT2 receptors.
Daptomycin Eluted From Calcium Sulfate Appears Effective Against Staphylococcus (2008)

The emergence of resistant strains of Gram-positive organisms in osteomyelitis creates treatment challenges. Daptomycin is an antibiotic that shows promise for treating some resistant strains of Gram-positive infections; however, it has not been widely used clinically for the treatment of osteomyelitis. We determined whether daptomycin eluted from calcium sulfate-a local delivery vehicle used for the treatment of osteomyelitis-retained activity against Gram-positive bacteria. Daptomycin was mixed with calcium sulfate hemihydrate, with both laboratory powder and a commercial kit, to form a hardened pellet. Daptomycin was eluted from calcium sulfate and retained its ability to inhibit bacterial growth of Staphylococcus aureus and Staphylococcus epidermidis for eluates gathered up to 28 days. Our preliminary data demonstrates sterilized pellets with daptomycin retained their ability to inhibit bacterial growth of certain strains of Gram-positive organisms.
INDUSTRIAL WASTES—Ozone in Air Pollution Abatement (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTINDUSTRIAL WASTES—Ozone in Air Pollution AbatementW. E. CromwellCite this: Ind. Eng. Chem. 1959, 51, 6, 83A–84APublication Date (Print):June 1, 1959Publication History Published online6 October 2008Published inissue 1 June 1959https://pubs.acs.org/doi/10.1021/ie50594a012https://doi.org/10.1021/ie50594a012research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cloning and expression of a human pro(tea)some β‐subunit cDNA: A homologue of the yeast PRE4‐subunit essential for peptidylglutamyl‐peptide hydrolase activity (1994)

The cDNA encoding a human prosome beta-subunit (HSBpros26) was isolated from a lymphoma library using the cDNA of the Xenopus homologue as a probe. The cDNA contains an open reading frame encoding a protein of 233 amino acids and a calculated molecular weight of 25,909. Comparison with interspecies homologues of HSBpros26 from Xenopus (XLB), rat (RN3) and yeast (PRE4) reveals a high degree of identity between the beta-subunits except for the N-terminal end, which is probably cleaved post-translationally. The complete coding sequence of HSBpros26 has been expressed in E. coli. The produced protein of about 27 kDa reacts with the prosomal monoclonal antibody MCP205, kindly provided by Dr. K. Hendil. The molecular weight of the native protein is about 28 kDa indicating that the protein is present as monomers. Finally partially purified HSBpros26 preparations do not contain any proteolytical activity.
Development of a Health-Related Quality of Life Measure for Peripheral Neuropathy (2000)

Results provide preliminary support for the measure's reliability and validity among adults with diabetic peripheral neuropathy. HRQOL was more strongly associated with symptom ratings than with examination and electrophysiologic test results.
The biology of <scp>Mur</scp> ligases as an antibacterial target (2014)

Summary With antibiotic resistance mechanisms increasing in diversity and spreading among bacterial pathogens, the development of new classes of antibacterial agents against judiciously chosen targets is a high‐priority task. The biochemical pathway for peptidoglycan biosynthesis is one of the best sources of antibacterial targets. Within this pathway are the Mur ligases, described in this review as highly suitable targets for the development of new classes of antibacterial agents. The amide ligases MurC , MurD , MurE and MurF function with the same catalytic mechanism and share conserved amino acid regions and structural features that can conceivably be exploited for the design of inhibitors that simultaneously target more than one enzyme. This would provide multi‐target antibacterial weapons with minimized likelihood of target‐mediated resistance development.
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion (2016)

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based on 3D migration models has revealed a diversity of invasive migratory schemes reflecting the plasticity of tumor cells to switch between proteolytic and nonproteolytic modes of invasion. Yet, initial stages of localized regional tumor dissemination require proteolytic remodeling of the extracellular matrix to overcome tissue barriers. Recent data indicate that surface-exposed membrane type 1-matrix metalloproteinase (MT1-MMP), belonging to a group of membrane-anchored MMPs, plays a central role in pericellular matrix degradation during basement membrane and interstitial tissue transmigration programs. In addition, a large body of work indicates that MT1-MMP is targeted to specialized actin-rich cell protrusions termed invadopodia, which are responsible for matrix degradation. This review describes the multistep assembly of actin-based invadopodia in molecular details. Mechanisms underlying MT1-MMP traffic to invadopodia through endocytosis/recycling cycles, which are key to the invasive program of carcinoma cells, are discussed.
iJam: Jamming Oneself for Secure Wireless Communication (2010)

Wireless is inherently less secure than wired networks because of its broadcast nature. Attacks that simply snoop on the wireless medium successfully defeat the security of even 802.11 networks using the most recent security standards (WPA2-PSK). In this paper we ask the following question: Can we prevent this kind of eavesdropping from happening? If so, we can potentially defeat the entire class of attacks that rely on snooping. This paper presents iJam, a PHY-layer protocol for OFDM-based wireless systems. iJam ensures that an eavesdropper cannot successfully demodulate a wireless signal not intended for it. To achieve this iJam strategically introduces interference that prevents an eavesdropper from decoding the data, while allowing the intended receiver to decode it. iJam exploits the properties of 802.11â s OFDM signals to ensure that an eavesdropper cannot even tell which parts of the signal are jammed. We implement iJam and evaluate it in a testbed of GNURadios with an 802.11-like physical layer. We show that iJam makes the data bits at the adversary look random, i.e., the BER becomes close to 50%, whereas the receiver can perfectly decode the data.
Disaster tolerant Wolfpack geo-clusters (2003)

Clustering of computer systems to increase application availability has become a common industry practice. While it does increase the availability of applications and their data to users, it does not solve the problem of a disaster (flood, tornado, earthquake, terrorism, civil unrest, etc.) making the entire cluster, and the applications and data it is serving, unavailable. Distance mirroring of an application's data store allows for recovery from disaster but may still result in long periods of unacceptable downtime. This paper describes a method for stretching a standard Wolfpack (Microsoft/sup /spl trade// Cluster Service, MSCS) cluster of Intel architecture servers geographically for disaster tolerance. Server nodes and their storage may be placed at two (or more) distant sites to prevent a single disaster from taking down the entire cluster. Standard cluster semantics and ease of use are maintained using the remote mirroring capabilities of Hewlett-Packard's high-end storage arrays. The design of additional software to control data mirroring behavior when moving or failing-over applications between server nodes is described. Also, software that allows "stretching" the cluster quorum disk between sites in a manner that is transparent to the cluster software and also software for an external arbitrator node that provides rapid recovery from total loss of inter-site communications is described. Flexibility provided by the array's firmware mirroring options (i.e. synchronous or asynchronous I/O mirroring) allows for optimum use of inter-site link bandwidth based on the data safety requirements of individual applications.
A circularly polarized UHF antenna at 550-700 MHz (2007)

The paper reports on a design of a low-cost circularly polarized turnstile bowtie antenna in the low UHF band (550 MHz-700 MHz) that has a wide impedance and polarization bandwidth (in excess of 20% at zenith assuming 3 dB axial ratio). In addition, the antenna should have a near omnidirectional RHCP radiation pattern in the upper hemisphere and a good front to back gain ratio.
Changes in the proportions of peripheral blood lymphocytes in patients with worn implants (2000)

We compared the peripheral blood and periprosthetic tissues of 53 patients at revision arthroplasty with those of 30 patients at primary arthroplasty to determine whether there is a systemic difference in lymphocytes in patients with worn hip implants. The absolute number and relative proportion of lymphocytes bearing CD2, CD3, CD4, CD8, CD16, CD19, HLA-DR, kappa and lambda antigens were compared with the levels of IL-1β, IL-6 and PGE 2 in the pseudosynovial membrane as well as with a semiquantitative estimate of metal and polyethylene particles, necrosis and chronic inflammation and the total concentration of metals within the periprosthetic tissues. There was a significant increase in the relative proportion of CD2-positive T-cells and CD16-positive natural killer cells in the peripheral blood at revision arthroplasty compared with primary arthroplasty and an increased proportion of CD8-positive T-cells and a decreased ratio of CD4 to CD8 (helper inducer/suppressor cytotoxic cells). Three control patients, who went on to have revision surgery, had values at primary arthroplasty which were similar to those of patients at the time of revision surgery. These differences did not correlate with the local concentration of metal, plastic or cement or inflammatory response or the type of prosthesis. An inverse correlation was noted between the necrosis in the periprosthetic tissue and both the local production of IL-6 and the absolute numbers of T-cells in peripheral blood. We conclude that there may be several cell-mediated systemic immune responses to aseptic loosening, at least one of which may be directly related to events in the periprosthetic tissues. We cannot exclude the possibility that the changes in the proportion of CD8-positive cells reflected a predisposition, rather than a reaction, to loosening of the implant.