gebhart/patrepeval huggingface dataset:
Therapeutic Drug Monitoring (1990)

A pilot study done at our institution and previous studies in the literature indicate that therapeutic drug monitoring (TDM) is frequently performed without a proper indication. In addition, samples are often improperly collected or interpreted by physicians. The purpose of this study was to determine if a pharmacy-based educational intervention could positively influence the performance of TDM in a teaching institution. A cost-savings analysis on the reduction of drug levels not indicated or improperly sampled was also performed. The study consisted of a preliminary data collection period, an educational intervention, and a postintervention data collection period. The pre- and posteducational intervention periods consisted of a 1-month concurrent review of aminoglycosides, digoxin, and theophylline serum levels. The educational intervention consisted of in-service programs and newsletter. There were 188 and 211 serum drug levels analyzed during the pre- and postintervention periods, respectively. Overall, the educational intervention significantly increased the number of drug levels obtained for rational indications, correctly sampled and appropriately interpreted by physicians (p less than 0.001, chi 2 analysis). Cost savings associated with this program was +2,788 in patient charges (+559 in hospital costs) per month. This study demonstrated that TDM may be significantly improved through education.
Diagnostic Utility of the WISC-III Developmental Index as a Predictor of Learning Disabilities (1996)

Wechsler's Deterioration Index (WDI) was developed as an indicator of cognitive impairment in adults but has been applied to children, because neuropsychological deficits have often been hypothesized to account for learning difficulties during the development period. Renamed the Wechsler Developmental Index, this measure has been used to discriminate among groups of children with and without learning disabilities. The present study replicated those findings with the Wechsler Intelligence Scale for Children-Third Edition, but also applied more appropriate diagnostic efficiency statistics to analyze the actual diagnostic utility of the WDI. These analyses revealed that the WDI performed at chance levels when distinguishing 611 students diagnosed with learning disabilities from those diagnosed with emotional disabled (n = 80) or mental retardation (n = 33), as well as from 2,200 simulated random nondisabled cases. It was concluded that mean group differences were not adequate and that ipsative indicators must be definitively validated in experimental environments before they can be applied in practice.
A simple linebreeding program for poultry breeders (1928)

It is practically impossible to increase egg production beyond a certain point in any flock of chickens without proper regard to mating and breeding. The old adage that it is impossible to squeeze blood out of a turnip also holds true in poultry keeping for, no matter how much care is given the birds, they cannot lay eggs beyond their HEREDITARY capacity.\nAs with egg production, hatchability, egg size and body weight cannot be increased beyond certain limits unless some constructive breeding program is followed. Altho this bulletin will deal with linebreeding for higher egg production, the same principles will apply for increasing hatchability, egg size and body weight.
Advanced SOI p-MOSFETs with strained-Si channel on SiGe-on-insulator substrate fabricated by SIMOX technology (2001)

We have newly developed an advanced SOI p-MOSFET with strained-Si channel on insulator (strained-SOI) structure fabricated by SIMOX (separation-by-implanted-oxygen) technology. The characteristics of this strained-SOI substrate and electrical properties of strained-SOI MOSFETs have been experimentally studied. Using strained-Si/relaxed-SiGe epitaxy technology and usual SIMOX process, we have successfully formed the layered structure of fully-strained-Si (20 nm)/fully-relaxed-SiGe film (290 nm) on uniform buried oxide layer (85 nm) inside SiGe layer. Good drain current characteristics have been obtained in strained-SOI MOSFETs. It is found that the hole mobility is enhanced in strained-SOI p-MOSFETs, compared to the universal hole mobility in an inversion layer and the mobility of control SOI p-MOSFETs. The enhancement of the drive current has been kept constant down to 0.3 /spl mu/m of the effective channel length.
Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis (2007)

AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs.
Antiplatelet Therapy Reduces Aortic Intimai Hyperplasia Distal to Small Diameter Vascular Prostheses (PTFE) in Nonhuman Primates (1982)

While the use of prosthetic grafts in small diameter arterial reconstruction is required when suitable autogenous graft material is unavailable, late occlusion of prosthetic grafts caused by proliferative lesions has been described. This study evaluated the suitability of 3-mm (ID) microporous polytetrafluoroethylene (PTFE) Gore-Tex grafts inserted in the abdominal aorta of eight nonhuman primates (Macaca fascicularis), and the effects of prolonged antiplatelet treatment on both graft patency and the development of intimal hyperplasia in the adjacent vasculature. Four monkeys received antiplatelet medication consisting of aspirin (163 mg twice daily) and dipyridamole (25 mg twice daily). When killed at four months following graft insertion, all four grafts in the antiplatelet medicated group were patent, while in the control group, only two of four grafts were patent. Histologic examination and quantitative photogravitometric evaluation of the degree of luminal narrowing were performed on all grafts and the adjacent vasculature. These studies revealed that while all graft and aortic segments showed varying amounts of intimal thickening, occlusions in the control animals were related to intimal hyperplasia in the host aorta at the site of the distal anastomosis. Intimal hyperplasia in all aortic segments examined distal to the graft was significantly reduced by antiplatelet therapy. Electronmicroscopy showed that smooth muscle cells were the predominant cells of the intimal thickening of the aorta (intimal hyperplasia), and that proliferation of these cells did not extend into the graft itself. The predominant cell population of the intimal thickening of the graft were of the myofibroblast type (neointimal hyperplasis). The luminal surface of the graft was lined with cells that had some but not all of the characteristics of mature endothelial cells. In vitro studies confirmed global interference with platelet function and arachidonic acid metabolism in medicated animals. Medication inhibited platelet cyclo-oxygenase without affecting platelet lipoxygenase, thromboxane synthetase, or prostacyclin-like activity in undisturbed arteries. This study shows that severe intimal hyperplasia develops rapidly in the recipient vessel adjacent to small diameter Gore-Tex grafts, and that the severity of the response is reduced by antiplatelet agents. Histologic examination revealed that the intimal thickening in the graft and the adjacent aortic segments were composed of cells that were not morphologically identical, suggesting two separate aetiologies and the possible need to use different approaches in their prevention.
Advanced Thermal Processing of Semiconductor Materials in the MSEC-Range (2006)

This paper reviews the advances that flash lamp annealing brings to the processing of the most frequently used semiconductor materials, namely silicon and silicon carbide, thus enabling the fabrication of novel microelectronic structures and materials. The paper describes how such developments can translate into important practical applications leading to a wide range of technological benefits. Opportunities in ultra-shallow junction formation, heteroepitaxial growth of thin films of cubic silicon carbide on silicon, and crystallization of amorphous silicon films, along with the technical reasons for using flash lamp annealing are discussed in the context of state-of-the-art materials processing
Passage of indigestible particles of various specific gravities in sheep and goats (1988)

1. Eight kinds of indigestible particles with specific gravities (SG) ranging from 0.92 to 1.87 (2 mm diameter and 4 mm length) were injected into the reticulo-rumen of sheep and goats in order to investigate the relation between SG and passage through the gastrointestinal tract, and the difference in passage time in the two species of animals. 2. The percentage of excreted particles significantly increased, while the percentage of ruminated particles in the excreted particles significantly decreased, as the SG increased. 3. The daily and cumulative recovery rates of particles of SG 1.38 were slower in sheep than in goats, while those with SG 0.92 were not different between species. 4. It is concluded that particles with SG higher than 1.27 would pass through the gastrointestinal tract of sheep and goats more quickly than those with SG lower than 1.21.
Application of vector quantized hidden Markov modeling to telephone network based connected digit recognition (2002)

Connected digit speech recognition in the telephone network is becoming increasingly more important as the demand for speech technology becomes widespread. In the past few years, several highly successful techniques for recognizing spoken connected digit strings have been proposed. Although these techniques have been applied to non-telephone based speech [e.g. Texas Instruments database], they have produced high recognition performance. Further, similar levels of performances have been demonstrated using discrete density and continuous density based hidden Markov models (HMMs). The success of the vector quantized (VQ) modeling approach, in particular, is encouraging and rather important from the viewpoint of computational efficiency. This paper presents a study of connected digit recognition on telephone network based data using VQ HMMs. We investigate several factors affecting the error rate of VQ HMMs-such as maximum mutual information (MMI) training, sender modeling, and codebook size-and measure their contributions to recognition accuracy. The model architecture, number of states and transitions, is also optimized and its contribution to overall performance discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Development of a polarization hyperspectral image projector (2012)

This paper describes the development of a new instrument for calibrating satellite imaging sensors - the Polarization Hyperspectral Image Projector (PHIP). The PHIP instrument is capable of producing realistic standards-based satellite imagery, simultaneously projecting spectral, spatial and polarization scenes. The feasibility study outlined here demonstrates that liquid crystal devices are capable of producing arbitrary polarization states. Boulder Nonlinear Systems is currently developing a complete spectral/spatial/polarization instrument to be delivered to NASA in 2013.
Identifying users' topical tasks in web search (2013)

A search task represents an atomic information need of a user in web search. Tasks consist of queries and their reformulations, and identifying tasks is important for search engines since they provide valuable information for determining user satisfaction with search results, predicting user search intent, and suggesting queries to the user. Traditional approaches to identifying tasks exploit either temporal or lexical features of queries. However, many query refinements are topical, which means that a query and its refinements may not be similar on the lexical level. Furthermore, multiple tasks in the same search session may interleave, which means we cannot simply order the searches by their timestamps and divide the session into multiple tasks. Thus, in order to identify tasks correctly, we need to be able to compare two queries at the semantic level. In this paper, we use a knowledgebase known as Probase to infer the conceptual meanings of queries, and automatically identify the topical query refinements in the tasks. Experimental results on real search log data demonstrate that Probase can indeed help estimate the topical affinity between queries, and thus enable us to merge queries that are topically related but dissimilar at the lexical level.
Antibodies specific for nucleic acid modifications (2017)

Nucleotide modifications constitute marks in RNA and DNA that contribute to gene regulation, development and other cellular processes. The understanding of their intricate molecular roles has been hampered by the high number of different modifications, the lack of effective methods and tools for their detection and quantification as well as by their complex structure-function relationship. The recent development of RNA and DNA immunoprecipitation followed by high-throughput sequencing (RIP- and DIP-seq) initiated detailed transcriptome- and genome-wide studies. Both techniques depend on highly specific and sensitive antibodies to specifically enrich the targeted modified nucleotides without background or potential biases. Here, we review the challenges and developments when generating and validating antibodies targeting modified nucleotides. We discuss antibody-antigen interactions, different strategies of antigen generation and compare different binder formats suitable for state-of-the-art high resolution mapping and imaging technologies.
Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a (2017)

Raw imaging data belonging to the manuscript 'Structural basis for guide RNA processing and seed-dependent DNA targeting and cleavage by CRISPR-Cas12a', by Swarts et al..
Efficient Parallel Framework for HEVC Motion Estimation on Many-Core Processors (2014)

High Efficiency Video Coding (HEVC) provides superior coding efficiency than previous video coding standards at the cost of increasing encoding complexity. The complexity increase of motion estimation (ME) procedure is rather significant, especially when considering the complicated partitioning structure of HEVC. To fully exploit the coding efficiency brought by HEVC requires a huge amount of computations. In this paper, we analyze the ME structure in HEVC and propose a parallel framework to decouple ME for different partitions on many-core processors. Based on local parallel method (LPM), we first use the directed acyclic graph (DAG)-based order to parallelize coding tree units (CTUs) and adopt improved LPM (ILPM) within each CTU (DAGILPM), which exploits the CTU-level and prediction unit (PU)-level parallelism. Then, we find that there exist completely independent PUs (CIPUs) and partially independent PUs (PIPUs). When the degree of parallelism (DP) is smaller than the maximum DP of DAGILPM, we process the CIPUs and PIPUs, which further increases the DP. The data dependencies and coding efficiency stay the same as LPM. Experiments show that on a 64-core system, compared with serial execution, our proposed scheme achieves more than 30 and 40 times speedup for 1920 × 1080 and 2560 × 1600 video sequences, respectively.
Films and Film-Makings: The Current Scene (1970)

I.C. Jarie's Movies and Society (Basic Books, $10.00) Gone Youngblood's Expanded Cinema (Dutton, $9.95) Robert Gessner's The Moving Image (Dutton $8.95) Robert Richardson's Literature and Film (University of Indiana Press, $4.95) Wolf Rilla's A-Z of Movie-Making (Viking/Studio Press Book, $6.95)
Separation of Gas Mixtures in Supersonic Jets (1963)

The supersonic jets resulting from the free expansion of nitrogen—hydrogen mixtures from small sonic nozzles were carefully studied by means of pressure and composition probing. The apparent concentration of heavy species in the core of the jet, originally observed by others, was confirmed. The mechanism by which this separation occurs is shown to be a consequence of the presence of the probe. The deceleration occasioned by the bow shock on the probe is suggested as the cause of the separation. The previously suggested mechanism of radial migration of light species from the jet axis does not seem to be applicable to the present results.
Inhibition of Mitogen-Activated Protein Kinases Phosphorylation Plays an Important Role in the Anti-nociceptive Effect of Pregabalin in Zymosan-Induced Inflammatory Pain Model (2014)

Although pregabalin has been shown to have preclinical and clinical efficacy in neuropathic pain, the mechanism of its antinociceptive action is still unknown in other pain states. This study aimed to evaluate the antinociceptive effect of pregabalin and its underlying spinal mechanisms related to mitogen activated protein kinases (MAPKs) in neuron and microglia following intraplantar injection of zymosan model. Zymosan evoked thermal hyperalgesia, mechanical hyperalgesia, and mechanical allodynia starting from 1 h and persistent until 5 h post-injection, which were dose-dependently reversed by oral pretreatment of pregabalin (3, 10, and 30 mg/kg). Pregabalin dramatically inhibited zymosan-induced Fos expression (a marker for neuronal activation) and microglia activation (using markers CD11b and ED1) in the spinal dorsal horn. Moreover, zymosan significantly increased phosphorylation of extracellular signal-regulated protein kinase (ERK) 1/2 (double labeling with neuron), ERK5 (double labelling with neuron and microglia) and p38 MAPK (double labeling with microglia) in the spinal dorsal horn, which overall elevations were reversed by pregabalin. These findings suggest that blockage of MAPKs activation in neuron and microglia might be closely related to the antinociceptive effect of pregabalin on zymosan-induced peripheral inflammatory pain.
Power Combining System Using Two Push Pull Power Amplifiers (1988)

This paper describes a power combining system using two push-pull power amplifiers. Power amplifiers using two different type phase inverter were proposed and tested at 5-GHz band. Bandwidth of these power combining systems were 1.65 GHz and 1.8 GHz, respectively, and either of their output power were 14.5 W.
The reactions of <i>C</i>‐methylheterocycles with thionyl chloride. Part <b>3</b>. The transformation of some five‐and six‐membered heterocycles (1989)

Abstract Reactions of various five‐and six‐membered C ‐methylheterocycles with hot thionyl chloride gave chlorothio intermediates which were not characterized but which gave 1,2,4‐thiadiazole derivatives when reacted with amidines and gave thioamides when reacted with amines. When 2,3‐dimethyl‐6‐ethoxycarbonylimidazo‐[4,5‐ b ]pyridine ( 26 ) was treated with thionyl chloride a trisulphane 27 was isolated.
Sarus: Highly Scalable Docker Containers for HPC Systems (2019)

The convergence of HPC and cloud computing is pushing HPC service providers to enrich their service portfolio with workflows based on complex software stacks. Such transformation presents an opportunity for the science community to improve its computing practices with solutions developed in enterprise environments. Software containers increase productivity by packaging applications into portable units that are easy to deploy, but generally come at the expense of performance and scalability. This work presents Sarus, a container engine for HPC environments that offers security oriented to multi-tenant systems, container filesystems tailored for parallel storage, compatibility with Docker images, user-scoped image management, and integration with workload managers. Docker containers of HPC applications deployed with Sarus on up to 2888 GPU nodes show two significant results: OCI hooks allow users and system administrators to transparently benefit from plugins that enable system-specific hardware; and the same level of performance and scalability than native execution is achieved.
AIDS: Safety, Regulation and the Law in Procedures Using Blood and Blood Products (1997)

The purpose of this paper is to examine issues of regulation of the market for, and use of, blood and blood products. The situation has changed since the discovery of the Human Immune Deficiency Virus (HIV), the presumed cause of AIDS, because it was recognized that some haemophiliacs were infected with HIV from transfused blood and blood products before 1985. When the danger was realized in that year, regulations were introduced internationally to prevent this, but meanwhile some haemophiliacs developed AIDS. In several countries, governments have accepted responsibility, without liability, for possible transmission of infection, and paid compensation to victims. In France three health service officials have been convicted of fraud and criminal negligence. In March 1997 a trial began in Japan of three drugs company executives accused of promoting the sale of HIV-contaminated blood products. Since then there has been a class action in the USA resulting in awards. Further issues have arisen with regard to the outcome and treatment of asymptomatic infection with HIV. The implications for public safety, and for medical and legal practice, are far reaching and reveal a need for more effective monitoring of the existing procedure for supply and clinical use of blood and blood products.
Moderate cytotoxicity of proanthocyanidins to human tumour cell lines (1995)

Abstract In the present study the cytotoxicity of 16 proanthocyanidins was evaluated in GLC4, a human small cell lung carcinoma cell line, and in COLO 320, a human colorectal cancer cell line, using the microculture tetrazolium (MTT) assay. With IC 50 values ranging from 18 to >200 μM following continuous incubation, the proanthocyanidins examined possess only moderate to low cytotoxicity. The highest cytotoxicity was found in a series of galloylated proanthocyanidins. An increase in the number of galloyl substituents increased cytotoxicity. Simple proanthocyanidins possess low cytotoxicity, that was independent of the stereochemistry. Compounds with doubly linked units had negligible cytotoxic effects, even at 200 μM, the highest concentration tested.
Possible Angiogenic Roles of Insulin-Like Growth Factor II and Its Receptors in Uterine Vascular Adaptation to Pregnancy (2003)

Adaptation of the maternal uterine vasculature is essential for normal fetal and placental development in which angiogenesis is considered one of the most critical adaptive changes during pregnancy. Highly expressed in cytotrophoblasts and maternal endothelial cells during pregnancy, IGF-II promotes cell migration and regulates fetal and placental growth. We hypothesized that IGF-II regulates uterine angiogenesis during pregnancy. Both uterine vasculature and isolated uterine microvascular endothelial cells expressed high levels of IGF-II and IGF-II/mannose-6 phosphate receptor mRNA as shown by in situ hybridization. Physiological concentrations of IGF-II significantly increased vessel formation, as shown by a three-dimensional angiogenesis assay in vitro or a chicken chorionallantoic membrane assay in vivo. The angiogenic response of IGF-II could be reversed by the addition of beta-galactosidase or rabbit-antihuman IGF-II/M6P receptor antiserum, whereas blocking antibodies against IGF-I receptor or insulin receptor influenced IGF-II-induced sprout formation. IGF-II promoted migration of endothelial cells (10-250 ng/ml) tested in a modified Boyden chamber, but no stimulating effect on proliferation was observed. The application of several intracellular signal transduction molecules and their inhibitors indicated that protein kinase C and G(i) protein might play a role in the IGF-II-induced angiogenesis. Our results suggest an important angiogenic role of IGF-II in the vascular adaptation to pregnancy.