gebhart/patrepeval huggingface dataset:
Effect of basic fibroblast growth factor and α‐melanocytic stimulating hormone on nerve regeneration through a collagen channel (1994)

An experimental study on the rat sciatic nerve was performed to evaluate nerve regeneration through a collagen guide and to study the effects of alpha-melanocytic stimulating hormone (alpha-MSH) and basic fibroblast growth factor (b-FGF) in accelerating axonal elongation. After transection, nerves were repaired over a 7 mm gap using a placental collagen type IV guide. The channel was filled with either a b-FGF solution or an alpha-MSH solution or was produced with b-FGF incorporated into the guide. Four weeks later, only groups in which b-FGF had been injected or incorporated displayed a significant somatosensory evoked potential response. Histological and quantitative analysis of nerve fibres confirmed the existence of nerve continuity in groups receiving an alpha-MSH solution or a channel containing b-FGF. These results demonstrate that alpha-MSH in solution and b-FGF incorporated into a collagen type IV channel enhance peripheral nerve regeneration. However, at 4 weeks, only b-FGF (3 ng) restores functional activity.
Complement-Dependent Acute-Phase Expression of C-Reactive Protein and Serum Amyloid P-Component (2000)

The acute-phase response (APR) is regulated by TNF-alpha, IL-1beta, and IL-6 acting alone, in combination, or in concert with hormones. The anaphylotoxin C5a, generated during complement activation, induces in vitro the synthesis of these cytokines by leukocytes and of acute-phase proteins by HepG2 cells. However, there is no clear evidence for a role of C5a or any other complement activation product in regulation of the APR in vivo. In this study, using human C-reactive protein (CRP) transgenic mice deficient in C3 or C5, we investigated whether complement activation contributes to induction of the acute-phase proteins CRP and serum amyloid P-component (SAP). Absence of C3 or C5 resulted in decreased LPS-induced up-regulation of the CRP transgene and the mouse SAP gene. Also, LPS induced both the IL-1beta and IL-6 genes in normocomplementemic mice, but in complement-deficient mice it significantly induced only IL-6. Like LPS injection, activation of complement by cobra venom factor led to significant elevation of serum CRP and SAP in normocomplementemic mice but not in complement-deficient mice. Injection of recombinant human C5a into human CRP transgenic mice induced the IL-1beta gene and caused significant elevation of both serum CRP and SAP. However, in human CRP transgenic IL-6-deficient mice, recombinant human C5a did not induce the CRP nor the SAP gene. Based on these data, we conclude that during the APR, C5a generated as a consequence of complement activation acts in concert with IL-6 and/or IL-1beta to promote up-regulation of the CRP and SAP genes.
<title>Investigation of real-time remote palpation imaging</title> (2001)

We are investigating a novel ultrasonic method for remote palpation, which provides images of local variations in tissue stiffness. Acoustic radiation force is applied to small volumes of tissue, and the resulting displacement patterns are imaged using ultrasonic correlation based techniques. Tissue displacements are inversely proportional to tissue stiffness, thus a stiffer region of tissue exhibits smaller displacements than a more compliant region. This method also provides information about tissue recovery after force cessation. We will present in vivo experimental results demonstrating the feasability of this method. Using intensities ranging from 120 to 300 W/cm<SUP>2</SUP>, peak displacements of up to 50 microns were observed after 1.4 milliseconds of force application. The tissue moved to its peak displacement within 3 milliseconds of force application, and the time constants for tissue recovery varied with tissue type. Tissue displacements appeared to be correlated with tissue structure in matched B-mode images. To our knowledge, these results represent the first in vivo soft tissue images generated using radiation force. These findings support the feasibility of Remote Palpation imaging. We will discuss the technical, safety, and clinical challenges of implementing a real-time Remote Palpation imaging system on a commercial diagnostic scanner.
The intermediate formation of [4]metacyclophane on flash vacuum thermolysis (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe intermediate formation of [4]metacyclophane on flash vacuum thermolysisGerardus B. M. Kostermans, Paul Van Dansik, Willem H. De Wolf, and Friedrich BickelhauptCite this: J. Org. Chem. 1988, 53, 19, 4531–4534Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/jo00254a021https://doi.org/10.1021/jo00254a021research-articleACS PublicationsRequest reuse permissionsArticle Views304Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wasserstein GANs for MR Imaging: From Paired to Unpaired Training (2020)

Lack of ground-truth MR images impedes the common supervised training of neural networks for image reconstruction. To cope with this challenge, this article leverages unpaired adversarial training for reconstruction networks, where the inputs are undersampled k-space and naively reconstructed images from one dataset, and the labels are high-quality images from another dataset. The reconstruction networks consist of a generator which suppresses the input image artifacts, and a discriminator using a pool of (unpaired) labels to adjust the reconstruction quality. The generator is an unrolled neural network - a cascade of convolutional and data consistency layers. The discriminator is also a multilayer CNN that plays the role of a critic scoring the quality of reconstructed images based on the Wasserstein distance. Our experiments with knee MRI datasets demonstrate that the proposed unpaired training enables diagnostic-quality reconstruction when high-quality image labels are not available for the input types of interest, or when the amount of labels is small. In addition, our adversarial training scheme can achieve better image quality (as rated by expert radiologists) compared with the paired training schemes with pixel-wise loss.
Fabrication and characterization of annular thickness mode piezoelectric micro ultrasonic transducers (2007)

Micromachining techniques, in combination with low temperature ceramic composite sol-gel processing, have been used to fabricate annular array thickness-mode piezoelectric micro ultrasonic transducers (Tm-pMUTs). The processing techniques of low temperature (710 degrees C) composite sol-gel ceramic (sol + ceramic powder) deposition and wet etching were used to deposit and structure 27-microm thick lead zirconate titanate (PZT) films on silicon substrates to produce annular array Tm-pMUTs. Using these techniques, high quality PZT materials with near bulk permittivity have been obtained. The Tm-pMUT devices were shown to resonate at approximately 60 MHz in air and 50 MHz in water. From resonance measurements k(t) values ranging between 0.2 and 0.47 have been calculated and shown to depend on the level of porosity within the film. Lower values of kt were observed for films with higher levels of porosity, which was attributed to the relative decrease in the effective piezoelectric coefficient epsilon(33) with respect to stiffness and permittivity as a function of increasing porosity. This paper presents the successful micro-fabrication of a Tm-pMUT device and discusses the optimization of the poling conditions and effect of PZT microstructure on the coupling coefficient k(t). Pulse echo measurements in water, showing a -6 dB center frequency of 53 MHz and 47% -6 dB bandwidth, using a target 15 mm away from the transducer, have been included to demonstrate successful operation of the device. Full analysis of these results will be conducted in later publications.
Reduced CD5+CD24hiCD38hi and interleukin-10+ regulatory B cells in active anti-neutrophil cytoplasmic autoantibody-associated vasculitis permit increased circulating autoantibodies (2014)

Pathogenesis of anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is B cell-dependent, although how particular B cell subsets modulate immunopathogenesis remains unknown. Although their phenotype remains controversial, regulatory B cells (Bregs ), play a role in immunological tolerance via interleukin (IL)-10. Putative CD19(+) CD24(hi) CD38(hi) and CD19(+) CD24(hi) CD27(+) Bregs were evaluated in addition to their CD5(+) subsets in 69 patients with ANCA-associated vasculitis (AAV). B cell IL-10 was verified by flow cytometry following culture with CD40 ligand and cytosine-phosphate-guanosine (CpG) DNA. Patients with active disease had decreased levels of CD5(+) CD24(hi) CD38(hi) B cells and IL-10(+) B cells compared to patients in remission and healthy controls (HCs). As IL-10(+) and CD5(+) CD24(hi) CD38(hi) B cells normalized in remission within an individual, ANCA titres decreased. The CD5(+) subset of CD24(hi) CD38(hi) B cells decreases in active disease and rebounds during remission similarly to IL-10-producing B cells. Moreover, CD5(+) B cells are enriched in the ability to produce IL-10 compared to CD5(neg) B cells. Together these results suggest that CD5 may identify functional IL-10-producing Bregs . The malfunction of Bregs during active disease due to reduced IL-10 expression may thus permit ANCA production.
Multi-channel conversion of the National Weather Radar Testbed receiver (2009)

The National Weather Radar Testbed (NWRT) system is based on WSR-88D technology enhanced with the significant capability of a Phased Array Antenna. The agile beam capability provides a unique and powerful tool to focus weather radar asset on observation of severe weather phenomena including structures that lead to formation of these storms. The NWRT system has demonstrated the ability to provide weather data consistent with that from adjacent WSR systems at greatly reduced volume coverage time. Significant success has been reported in use of this tool for gathering and presenting specific, real-time storm-cell 3-D data to weather scientists and meteorologists for in-depth interpretation of these pencil-beam radar returns. Specific extensions to the conventional weather radar capabilities now in place include Beam Multiplexing (spatial filtering), Oversampling and Whitening (signal processing) and Transverse Wind Estimation (multi-beam). The latter capability has recently been added by activating the difference beam channels of the array and sequentially sampling and comparing these with the conventional sum-only mode. Under the auspices of a National Science Foundation, Major Research Instrument (NSF/MRI) grant, and in cooperation with the United States Navy, the NWRT is now being extended with an 8-channel digital receiver for simultaneous processing of sum, difference and ancillary beam returns. Expectations are high that application of multi-beam adaptation algorithms and other signal processing techniques using multiple channels will lead to improved detection and storm queuing techniques to greatly extend the forecast lead time for severe storms. Multi-channel capability also opens the NWRT for the possibility of testing Multi-Function radar system algorithms and operations. This paper will describe the attributes of the COTS, rf-system extensions and the specific steps being taken to baseline these changes to the current NWRT system performance.
Tissue distribution of UT-A and UT-B mRNA and protein in rat (2005)

Mammalian urea transporters are facilitated membrane transport proteins belonging to two families, UT-A and UT-B. They are best known for their role of maintaining the renal inner medullary urinary concentrating gradient. Urea transporters have also been identified in tissues not typically associated with urea metabolism. The purpose of this study was to survey the major organs in rat to determine the distribution of UT-A and UT-B mRNA transcripts and protein forms and determine their cellular localization. Five kidney subregions and 17 extrarenal tissues were screened by Northern blot analysis using two UT-A and three UT-B probes and by Western blot analysis using polyclonal COOH-terminal UT-A and UT-B antibodies. Immunohistochemistry was performed on 16 extrarenal tissues using the same antibodies. In kidney, we detected mRNA transcripts and protein bands consistent with previously-identified UT-A and UT-B isoforms, as well as novel forms. We found that UT-A mRNA and protein are widely expressed in extrarenal tissues in various forms that are different from the known isoforms. We determined the cellular localization of UT-A and UT-B in these tissues. We found that both UT-A and UT-B are ubiquitously expressed as numerous tissue-specific mRNA transcripts and protein forms that are localized to cell membranes, cytoplasm, or nuclei.
Hospice and Palliative Care (2006)

At the National Hospice and Palliative Care Organization's 6th Clinical Team Conference on Hospice and Palliative Care, held April 21-23, 2005, in Atlanta, Georgia, Perry G. Fine, MD, Professor in the Department of Anesthesiology at the University of Utah in Salt Lake City and Vice President of Medical Affairs for the National Hospice and Palliative Care Organization interviewed Louis W. Sullivan, MD, former Secretary of the US Department of Health and Human Services and currently President Emeritus of Morehouse School of Medicine, Chair of the Sullivan Commission—a commission to increase diversity among health professionals, Chair of the National Health Museum, Cochair of the President's Commission on HIV/AIDS, and Chair of the President's Commission on Black Colleges and Universities, as well as Chair of Medical Education for South African Blacks. Dr. Fine and Dr. Sullivan discussed the importance of hospice and palliative care, along with some of the practical issues facing clinicians who wish to use the hospice care system.
Very high linearity tunable OTA in 5 V CMOS (1993)

A fully differential OTA with a digitally programmable transconductance value is presented. The design has been optimised for high linearity at moderate frequencies. The simulated THD for a single-ended output of amplitude 2.2 VP-P across an 80 kHz bandwidth is ≤ —88 dB. When a five-bit tuning code is used the transconductance value is tunable over a range of ±50% and has a maximum quantisation error of ±5%. A new automatic tuning scheme requiring no external components is suggested.
Synthesis of Physiologically Active Substances, part VII. Synthesis of Terpenyl Amides with Monoterpene Groups and Their Evaluation as Mosquito Repellents. (1993)

2a),(+)
Mites associated with poultry feed in Hisar, Haryana (India) (2002)

Examination of samples of poultry feed at different poultry farms of Hisar, Haryana (India) showed the presence of live mites as contaminant. The mites encountered were: Astigmata: Acaridae, Aleuroglyphus ovatus (Troupeau), Rhizoglyphus sp., Thyreophagus entomophagus (Laboulbene), Tyrophagus sp., Mesostigmata Ameroseiidae, Neocypholaelaps sp., Laelapidae, Hypoaspis marksi Strandtmann and Crossley Jr., Urodinychidae, Leiodinychus parasiticus, Choudhury and Mukherjee, Prostigmata: Cheyletidae, Cheletophanes sp. Cheyletus eruditus (Schrank), C. fortist Oudemans, C. malaccenisis Oudemans, C. trouessartia Oudemans, C. trux Rodendorf, and Nodele philippinensis (Baker). The mite, Leiodinychus parasiticus was the most dominant contaminant of poultry feed in Hisar. The seven species of predatory mites of the family Cheyletidae must be keeping a natural control of harmful mites in the poultry feed, All the mites are the first record for their occurrence from poultry feed in Haryana state.
A Sequential C—N, C—C Bond‐Forming Reaction: Direct Synthesis of α‐Amino Acids from Terminal Alkynes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Automatic generation of parallel CRC circuits (2001)

A parallel CRC circuit simultaneously processes multiple data bits. A generic VHDL description of parallel CRC circuits lets designers synthesize CRC circuits for any generator polynomial or required amount of parallelism.
Further Studies on Thermal Stability of Modified 718 Alloys (1994)

Continuing the effort to redesign Alloy 718 in order to provide microstructural and mechanical stability beyond 650C, three modified compositions were studied after appropriate heat treatments. These alloys have demonstrated better thermal stability than conventional Alloy 718 at and above 65O'C. In this study, emphasis was placed on the relative stability of the alloy having a non-compact y'/y" precipitate structure compared to the one having the cube-shaped, compact ~'/y" precipitate structure when aged for 500 and 1000 hr at 700 C. Tensile tests at ambient and at 700C and stress rupture testing at 700C under 638 MPa (92.5 ksi) were conducted both before and after these exposures. Better results were obtained with the non-compact precipitate Y '/-I" morphology and attributed to a lower coarsening (growth) rate of the y' and y" phases for these thermal and stress-enhanced conditions. It should be recognized that this alloy had a W addition to provide increased strength and a slower rate of y" coarsening. The third alloy changed from a cube-shaped y'/y" morphology to a mixture of basically non-compact y'/y" precipitate after the thermal treatments and ranked below the two major emphasis alloys.
Defining dementia: clinical criteria for the diagnosis of vascular dementia (2002)

The recognition of cerebrovascular disease (CVD) as a contributing factor and a cause of dementia has led to the development of clinical criteria for vascular dementia (VaD). Due to high specificity, the consensus criteria developed by the National Institute for Neurological and Communicative Disorders and Stroke (NINDS)-Association Internationale pour la Recherche et l'Enseignement en Neurosciences (AIREN) have been used in controlled clinical trials to select patients with pure VaD. VaD is predominantly a subcortical frontal form of dementia with prominent executive dysfunction. In contrast, the criteria of the NINCDS-Alzheimer's Disease and Related Disorders Association (ADRDA) emphasize memory loss as the main feature to distinguish Alzheimer's disease (AD) from VaD and from other forms of dementia. Moreover, CVD may precipitate the clinical expression of AD. Although no criteria have been created specifically for patients having AD with CVD, the ischemic score, the Informant Questionnaire on Cognitive Decline in the Elderly and a history of prestroke mild cognitive impairment (MCI) may be useful for identifying patients with this mixed form of dementia.
Unconstrained licence plate and text localization and recognition (2005)

Licence plates and traffic signs detection and recognition have a number of different applications relevant for transportation systems, such as traffic monitoring, detection of stolen vehicles, driver navigation support or any statistical research. A number of methods have been proposed, but only for particular cases and working under constraints (e.g. known text direction or high resolution). Therefore a new class of locally threshold separable detectors based on extremal regions, which can be adapted by machine learning techniques to arbitrary shapes, is proposed. In the test set of licence plate images taken from different viewpoints (-45/spl deg/,45/spl deg/), scales (from seven to hundreds of pixels height) even in bad illumination conditions and partial occlusions, the high detection accuracy is achieved (95%). Finally we present the detector generic abilities by traffic signs detection. The standard classifier (neural network) within the detector selects a relevant subset of extremal regions, i.e. regions that are connected components of a thresholded image. Properties of extremal regions render the detector very robust to illumination change and partial occlusions. Robustness to a viewpoint change is achieved by using invariant descriptors and/or by modelling shape variations by the classifier. The time-complexity of the detection is approximately linear in the number of pixel and a non-optimized implementation runs at about 1 frame per second for a 640 /spl times/ 480 image on a high-end PC.
Image restoration in astronomy: a Bayesian perspective (2001)

When preparing an article on image restoration in astronomy, it is obvious that some topics have to be dropped to keep the work at reasonable length. We have decided to concentrate on image and noise models and on the algorithms to find the restoration. Topics like parameter estimation and stopping rules are also commented on. We start by describing the Bayesian paradigm and then proceed to study the noise and blur models used by the astronomical community. Then the prior models used to restore astronomical images are examined. We describe the algorithms used to find the restoration for the most common combinations of degradation and image models. Then we comment on important issues such as acceleration of algorithms, stopping rules, and parameter estimation. We also comment on the huge amount of information available to, and made available by, the astronomical community.
Radon-Fourier transforms on symmetric spaces and related group representations (1965)

First published in the Bulletin of the American Mathematical Society in Vol.71, 1965, published by the American Mathematical Society
Associations of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Mass Index With Mortality and Cardiovascular Outcomes in the General Population (2018)

High variability of fasting blood glucose and total cholesterol levels, systolic blood pressure, and body mass index was an independent predictor of mortality and cardiovascular events. There was a graded association between the number of high-variability parameters and cardiovascular outcomes.
Micro Scale Laser Shock Processing of Metallic Components (2002)

Laser shock processing of copper using focused laser beam size about ten microns is investigated for its feasibility and capability to impart desirable residual stress distributions into the target material in order to improve the fatigue life of the material. Shock pressure and strain/stress are properly modeled to reflect the micro scale involved, and the high strain rate and ultrahigh pressure involved. Numerical solutions of the model are experimentally validated in terms of the geometry of the shock-generated plastic deformation on target material surfaces as well as the average in-depth strains under various conditions. The residual stress distributions can be further influenced by shocking at different locations with certain spacing. The potential of applying the technique to micro components, such as micro gears fabricated using MEMS is demonstrated. The investigation also lays groundwork for possible combination of the micro scale laser shock processing with laser micromachining processes to offset the undesirable residual stress often induced by such machining processes.