gebhart/patrepeval huggingface dataset:
In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-Disease (2012)

Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic cell transplantation and is largely mediated by activated donor lymphocytes. Lymphotoxin (LT)-α is expressed by subsets of activated T and B cells, and studies in preclinical models demonstrated that targeted depletion of these cells with a mouse anti-LT-α monoclonal antibody (mAb) was efficacious in inhibiting inflammation and autoimmune disease. Here we demonstrate that LT-α is also upregulated on activated human donor lymphocytes in a xenogeneic model of GVHD and targeted depletion of these donor cells ameliorated GVHD. A depleting humanized anti-LT-α mAb, designated MLTA3698A, was generated that specifically binds to LT-α in both the soluble and membrane-bound forms, and elicits antibody-dependent cellular cytotoxicity (ADCC) activity in vitro. Using a human peripheral blood mononuclear cell transplanted SCID (Hu-SCID) mouse model of GVHD, the anti-human LT-α mAb specifically depleted activated LT-expressing human donor T and B cells, resulting in prolonged survival of the mice. A mutation in the Fc region, rendering the mAb incapable of mediating ADCC, abolished all in vitro and in vivo effects. These data support a role for using a depleting anti-LT-α antibody in treating immune diseases such as GVHD and autoimmune diseases.
Influence of an in-plane magnetic field on the domain-wall velocity in Ga: YIG films (1973)

Results are reported of an investigation on the velocity of a single straight magnetic domain wall in a Ga:YIG film as a function of the drive field and of a static magnetic field applied perpendicular to the wall in the plane of the film. At all drive fields a substantial increase of the wall velocity was observed when the in-plane field was applied. At an in-plane field of about 400 Oe and at a rather low drive field (2.4 Oe above the coercive field) a maximum value in wall velocity of 270 ms <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> was observed. At higher drive fields the wall velocity decreased to a constant value of 110 ms <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , independent of the drive field. This behavior can be explained by extending Slonczewski's theory of domain wall motion to the present case. From the observed wall mobility parameter we have calculated the reduced Landau-Lifshitz damping constant <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\lambda/\gamma^{2}</tex> ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3.7 \times 10^{-9}</tex> Oe <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> s). This value is near to the value obtained by Spencer and LeCraw from linewidth measurements in FMR on Ga:YIG spheres ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5 \times 10^{-10}</tex> Oe <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> s).
High Reliable and Manufacturable Gallium Indium Zinc Oxide Thin-Film Transistors Using the Double Layers as an Active Layer (2009)

High reliable bottom gate amorphous gallium indium zinc oxide (a-GIZO) thin-film transistors (TFTs) have been fabricated by using the double active layers. Top and bottom layers were CuGaInZnO (CGIZO) and GIZO, respectively. When the plasma-enhanced processes were introduced during fabrication of the TFTs, the TFT with a-GIZO single active layer did not exhibit electrically reliable performance due to forming the conducting surface layer from the plasma damages. The double-active-layer TFT with a CGIZO layer had the reliable performance ( of , of , subthreshold gate swing value of /decade, of ) even under the same processes. This suggested that the Cu atom of CGIZO layer suppressed the carrier concentration during plasma-enhanced processes. The TFTs with double active layer showed excellent stability, which has the threshold voltage shift of at drain current under for .
Simultaneous determination of five quinoxaline-1,4-dioxides in animal feeds using an immunochromatographic strip (2015)

An immunochromatographic (ICG) strip was developed for the simultaneous quantitative determination of five quinoxaline-1,4-dioxides in animal feed. For this purpose, polyclonal antibodies (PcAb) with group-specific quinoxaline-1,4-dioxides were conjugated to colloidal gold particles as the detection reagent for ICG strips to test for quinoxaline-1,4-dioxides. This method achieved semi-quantitative detection of quinoxaline-1,4-dioxides within 5-10 min. The visual lower detection limits of the strip for quinocetone, cyadox, carbadox, mequindox and olaquindox were 10, 15, 15, 20 and 20 ng ml(-1), respectively. Using an ICG strip reader, the 50% inhibitions (IC50 values) were calculated to be 9.1, 13.5, 16.6, 20.2 and 21.3 ng ml(-1) for quinocetone, cyadox, carbadox, mequindox and olaquindox, respectively. When used to analyse samples of animal feed, acceptable recovery rates of 77.5-99.5% and coefficients of variation (CVs) of 4.3-10.7% were obtained. Levels measured with the ICG strip for 10 spiked samples were confirmed by HPLC with a high correlation coefficient of 0.9965 (n = 10). In conclusion, the method was rapid and accurate for simultaneous determination of five quinoxaline-1,4-dioxides antibiotics in animal feed.
Synthesis of repeating sequence copolymers of lactic, glycolic, and caprolactic acids (2011)

Abstract Repeating sequence copolymers of poly(lactic‐ co ‐caprolactic acid) (PLCA), poly(glycolic‐ co ‐caprolactic acid) (PGCA), and poly(lactic‐ co ‐glycolic‐ co ‐caprolactic acid) (PLGCA) have been synthesized by polymerizing segmers with a known sequence in yields of 50–85% with M n s ranging from 18–49 kDa. The copolymers exhibited well‐resolved NMR resonances indicating that the sequence encoded in the segmers used in their preparation is retained and that transesterification is minimal. The exact sequences allowed for unambiguous assignment of the NMR spectra, and these standards were compared with the data previously reported for random copolymers. The glass transition temperatures ( T g s) of the PLCA and PGCA copolymers were found to depend primarily on monomer ratio rather than sequence. Sequence dependent T g s were, however, noted for the PLGCA polymers with 1:1:1 L:G:C ratios; poly LGC and poly GLC exhibited T g s that differed by nearly 8 °C. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Chemical Vapor Deposition of Selective Epitaxial Silicon Layers (1990)

A process of selective epitaxial growth of silicon on an oxide‐patterned substrate is developed, and the quality of the deposited silicon film is characterized. Good selectivity is achieved in depositing silicon only in the area where the silicon substrate is exposed and not in the areas covered with the oxide. The quality of the deposited silicon film is investigated by SEM and TEM. No dislocations are observed in the samples investigated by TEM. The junction leakage of diodes fabricated on these samples is measured. At a reverse bias of 5V, a leakage current density of 30 nA/cm2 is obtained. Precleaning at 1025°C for 3 min in for the patterned Si substrate was found to be adequate to produce good quality Si films. The size of the facet was found to be reduced by lowering the flow rate of the during the deposition.
Feature Interactions in P2P Overlay Networks (2008)

Current P2P communication applications offer only a limited set of call processing services. However, this is likely to change due to services being integrated into the overlay and third party service provisioning. The particular focus of this paper is the problem of feature interactions. We illustrate some examples and show the applicability of previous methods of telephony feature interaction analysis to the peer-to-peer model.
Transplantation of Cultured Human Corneal Endothelial Cells (2003)

To reconstruct corneas that are the same as, or superior to, normal corneas, innovation is necessary in the methods used for culturing and seeding HCECs. Porcine corneal stroma is promising as a carrier of HCECs instead of human corneal stroma, the supply of which is limited. The validity of porcine corneal stroma, acellularized to prevent retrovirus infection, should be evaluated.
Glucose metabolism in the brain (2002)

Introduction:Energy Metabolism in the Brain The Cerebral Glucose-Fatty Acid Cycle: Evolutionary roots, regulation, and (patho)physiological importance Expression, Regulation and Functional Role of Glucose Transporters (GLUTs) in Brain Insulin-Like Growth Factor 1 Promotes Neuronal Glucose Utilization During Brain Development and Repair Processes CNS Sensing and Regulation of Peripheral Glucose Levels Glucose Transporter Protein Syndromes Glucose, Stress, and Hippocampal Neuronal Vulnerability Glucose/Mitochondria in Neurological Conditions Energy Utilization in the Ischemic/Reperfused Brain Diabetes Mellitus and the Central Nervous System Glucose, Memory, and Cognition Diabetes, the Brain and Behavior:Is there a biological mechanism underlying the association between diabetes and depression Schizophrenia and Diabetes Psychoactive Drugs Affect Glucose Transport and the Regulation of Glucose Metabolism
Modeling Infrastructure Sharing in mmWave Networks With Shared Spectrum Licenses (2018)

Competing cellular operators aggressively share infrastructure in many major U.S. markets. If operators were also to share spectrum in next-generation millimeter-wave (mmWave) networks, intra-network interference will become correlated with inter-network interference. We propose a mathematical framework to model a multi-operator mmWave cellular network with co-located base-stations (BSs). We then characterize the signal-to-interference-plus-noise ratio distribution for an arbitrary network and derive its coverage probability. To understand how varying the spatial correlation between different networks affects coverage probability, we derive special results for the two-operator scenario, where we construct the operators' individual networks from a single network via probabilistic coupling. For external validation, we devise a method to quantify and estimate spatial correlation from actual BS deployments. We compare our two-operator model against an actual macro-cell-dominated network and an actual network primarily comprising distributed-antenna-system (DAS) nodes. Using the actual deployment data to set the parameters of our model, we observe that coverage probabilities for the model and actual deployments not only compare very well to each other, but also match nearly perfectly for the case of the DAS-node-dominated deployment. Another interesting observation is that a network that shares spectrum and infrastructure has a lower rate coverage probability at low rate thresholds than a network of the same number of BSs that shares neither spectrum nor infrastructure, suggesting that the latter is more suitable for low-rate applications.
Homograft (Allograft) Tympanoplasty Update (1986)

If homograft tympanoplasty is to be of value, specific instances in which homograft tympanic membrane, malleus, and incus (TMMI) provide significant hearing and anatomical advantages over standard techniques should be identified. This author has performed 305 homograft tympanoplasties limited to the reconstruction of the severely damaged middle ear. Indications include: previous failure with standard tympanoplasty techniques; high risk of anatomic or hearing failure with standard techniques (total perforation with absent malleus, slag burns); reconstruction of radical mastoidectomy; congenital aural atresia. The first 125 consecutive homograft tympanoplasties were reported in 1982. One hundred eighty additional homograft tympanoplasties have been performed since then. In the past 3 years the anatomic success rate has risen to 97% (174/180) with refinement of surgical techniques. Eighty-five percent of all patients have maintained an average air-bone gap of 25 dB or better. Formalin preserved homograft tympanic membranes with attached malleus offer significant advantages over standard tympanoplasty techniques in these specific indications.
The Activity of Some Nucleolytic Enzymes in Semen and in the Secretions of the Male Reproductive Tract (2009)

The activity of 5'-nucleotidase (EC 1.3.5), cyclic nucleotide phosphodiesterase (EC 2.1.4.17), non-specific phosphodiesterase (EC 3.1.4.1) and ribonuclease (EC 1.7.7.16)has been investigated in the seminal plasma of whole semen and in the secretions of the seminal vesicle, prostate and epididymis of the bull, boar, ram, stallion, jackass, rabbit and man. Bull seminal plasma showed the highest activity for 5'-nucleotidase, cyclic nucleotide phosphodiesterase and ribonuclease; in contrast, stallion and jackass semen were very poor in these enzymes. Ram, rabbit and boar seminal plasma showed intermediate levels for all enzymes studied. In the bull and ram, nucleolytic enzymes were found to be secreted by the seminal vesicles but in the boar, rabbit and stallion they originate mostly from the epididymis. In human seminal plasma all of the enzymes studied exhibited activity but the levels were generally lower than those recorded for the other species.
Effective resource utilization for multiprocessor join execution (1989)

Conventional approaches 10 execution of database queries on general purpose multiprocessors anempt to maximize system throughput using inter-query parallelism with a fixed number of processors.Standard uniprocessor optimization techniques are used 10 minimize execution time of individual queries.Our approach is 10 increase pcrfonnance by utilizing intra-query parallelism as well as minimizing overall resource requirements.Specifically, processor and i/o bandwidth requirements"are minimized by coordinating the order in which data pages are read into memory and page joins assigned to available processors.We present a scheduling strategy based on join indices and prove lower and upper bounds on its resource requirements.We then describe a heuristic for estimating the number of processors required to complete join execution in minimal time.Our simulation results indicate that these techniques are effective with respect 10 processor utilization and buffer requirements.1.
Randomized clinical trial of the effect of perioperative synbiotics <i>versus</i> no synbiotics on bacterial translocation after oesophagectomy (2014)

ID 000003262 (University Hospital Medical Information Network, http://www.umin.ac.jp).
Facile Synthesis of Phosphaamidines and Phosphaamidinates using Nitrilium Ions as an Imine Synthon (2014)

Readily accessible nitrilium triflates are convenient imine building blocks for the expedient synthesis of a novel class of 1,3-P,N ligands as demonstrated for the reaction with primary phosphanes. This procedure allows variation of all substituents. X-ray crystal structures are reported for nitrilium ions, phosphaamidines, and three phosphaamidinate complexes. The lithium phosphaamidinate is N coordinated and its reaction with [AuCl(tht)] (tht = tetrahydrothiophene) gives a unique P-bridged gold trimer, while a P,N-bidentate complex results from [{RhCl(cod)}2]. The nitrilium ion methodology allows extension of the 1,3-P,N motive to bis(imino)phosphanes, which are the neutral phosphorus analogues of the valuable β-diketiminate ligand.
Shape memory alloy honeycombs: experiments & simulation (2007)

Metallic foams and honeycombs, with their light-weight, high speciflc stifiness, and well-developed energy absorption characteristics, are of obvious utility in engineering applications. However, these structures, often made of aluminum, sufier permanent deformation after crushing. Cellular structures made from shape-memory alloys (SMAs) are particularly intriguing for their potential to deliver shape memory and/or superelasticity in a light-weight material. Realization of open-celled Nitinol has recently become possible via a (newly discovered by Profs. D. Grummon at Michigan State Univ. and J. Shaw at Univ. of Michigan) transient-liquid reactive brazing system for creating robust metallurgical Nitinol-Nitinol bonds. With this technique, prototype sparse cellular honeycomb structures have been made and tested, showing up to 50% repeatedly recoverable strains. Two difierent microgeometry NiTi honeycombs have been tested, a hexagonal for isothermal conditions and a corrugated for thermal cycling. Moreover, the isothermal experiments are simulated using a model that accounts for flnite rotations and hysteretic responce of the ligaments and geometric imperfections of the flnite size samples.
Fluorescent dopants in organic electroluminescent devices (1998)

The PL and EL characteristics of several blue Alq (BAlq) emitters and the effect of doping with blue and red fluorescent molecules have been studied. Substitution at the 2 and 4 positions was found to produce a substantial blue shift in the emission peak relative to the green Alq and a relatively large improvement in the fluorescence quantum efficiency. Doping perylene and DCJTM in these BAlq was found to be useful in tuning the emission colors form blue to orange-red, including white, with improvements in the operational stability.© (1998) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Phosphonate mediated surface reaction and reorganization: implications for the mechanism controlling cement hydration inhibition (2005)

Vertical scanning interferometry and XPS show the reaction of CaCO3 with the hydration retarder nitrilo-tris-(methylene)phosphonic acid follows a pathway of dissolution of the calcium followed by precipitation of a calcium phosphonate; subsequent surface reorganization/restructuring of the calcium phosphonate exposes the underlying CaCO3 for further hydration.
Bioactive materials for biomedical applications using sol–gel technology (2008)

This review paper focuses on the sol-gel technology that has been applied in many of the potential research areas and highlights the importance of sol-gel technology for preparing bioactive materials for biomedical applications. The versatility of sol-gel chemistry enables us to manipulate the characteristics of material required for particular applications. Sol-gel derived materials have proved to be good biomaterials for coating films and for the construction of super-paramagnetic nanoparticles, bioactive glasses and fiberoptic applicators for various biomedical applications. The introduction of the sol-gel route in a conventional method of preparing implants improves the mechanical strength, biocompatibility and bioactivity of scaffolds and prevents corrosion of metallic implants. The use of organically modified silanes (ORMOSILS) yields flexible and bioactive materials for soft and hard tissue replacement. A novel approach of nitric-oxide-releasing sol-gels as antibacterial coatings for reducing the infection around orthopedic implants has also been discussed.
Crosslinking of collagen with dendrimers (2005)

Polypropyleneimine octaamine dendrimers were studied as an alternative means of generating highly crosslinked collagen. Crosslinking was effected by using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC). The multifunctional dendrimers were introduced as novel crosslinkers after the activation of the carboxylic acid groups of glutamic and aspartic acid residues in collagen. The conventional crosslinker glutaraldehyde was used as a control. EDC, itself an alternative crosslinker, which forms zero-length crosslinks by directly covalently binding collagen molecules, as well as a low molecular weight diamine and a low molecular weight triamine, were also studied. All of the resultant gels were freeze-dried to obtain sponges for characterization. Water uptake of the gels decreased from 90% to 60% after dendrimer crosslinking compared with EDC crosslinking. DSC results showed an increase of denaturation temperature of collagen after crosslinking with the various methods. The generation 2 and 3 dendrimer-crosslinked collagen samples had the highest denaturation temperature, at up to 90 degrees C compared with 50 degrees C in the uncrosslinked collagen control. The dendrimer-crosslinked collagen also showed unique thermal characteristics, with multiple denaturation temperature peaks in contrast to the single peak noted with the other crosslinked collagens. This is thought to be due to the heterogeneous nature of dendrimer crosslinking. Collagenase results revealed that the dendrimer-crosslinked collagen had a comparative resistance to proteolysis to glutaraldehyde-crosslinked collagen. Measurement of activated carboxylic acid groups before and after crosslinking indicated that 40-70% of the activated carboxylic acid was consumed during crosslinking with dendrimers. The results suggest that dendrimer crosslinking of collagen produces stable gels. The presence of a large number of excess amine groups in the dendrimers may also be useful for subsequent modification with biologically relevant groups.
The effects of surfactant additives on the acoustic and light emissions from a single stable sonoluminescing bubble (1997)

The localized concentration of energy during a single bubble collapse is manifested in two forms, which are the emission of an acoustic pulse, and the emission of a light pulse. Through precise control of experimental parameters, one can levitate a single bubble in a standing wave field and measure the magnitude of the acoustic and light pulses resulting from the violent collapse of the cavity. The information acquired from such measurements provides better understanding of the mechanisms that are responsible for the emissions, which may lead to the practical application of controlled bubble implosions. An experimental apparatus was developed to measure the acoustic and light emissions from a single, stable sonoluminescing bubble. Two surfactant additives were studied to determine the effects on the bubble emissions. Triton X-100, which has previously been shown to provide free interfacial motion, reduced the magnitude of both the acoustic and light pulses from the bubble. The protein bovine serum albumin (BSA) which has been shown to hinder interfacial motion, allowed the bubble to be driven to higher acoustic pressures, and resulted in an increase in the magnitude of the light pulses from the bubble. Images of the sonoluminescing bubble indicate that the collapse remains spherical in the cases presented, and that bubble translation can be correlated with weak acoustic and light emissions.
ChemInform Abstract: Dioxygen Adsorption on Well‐Outgassed and Partially Reduced Cerium Oxide Studied by FT‐IR. (1989)

Abstract Adsorption of O 2 at 20 °C on well‐outgassed (1000 K) CeO 2 gives rise to IR bands at 2237 and 1126 cm ‐1 , which are attributed to superoxide species O2 ‐ (ads).