gebhart/patrepeval huggingface dataset:
Sensitivity and Specificity of the Functional Hallux Limitus Test to Predict Foot Function (2002)

Functional hallux limitus is an underrecognized entity that generally does not produce symptoms but can result in a variety of compensatory mechanisms that can produce symptoms. Clinically, hallux limitus can be determined by assessing the range of motion available at the first metatarsophalangeal joint while the first ray is prevented from plantarflexing. The aim of this study was to determine the sensitivity and specificity of this clinical test to predict abnormal excessive midtarsal joint function during gait. A total of 86 feet were examined for functional hallux limitus and abnormal pronation of the midtarsal joint during late midstance. The test had a sensitivity of 0.72 and a specificity of 0.66, suggesting that clinicians should consider functional hallux limitus when there is late midstance pronation of the midtarsal joint during gait.
Current concepts in colorectal cancer prevention with cyclooxygenase inhibitors. (2014)

Colorectal cancer is one of the commonest malignancies worldwide. Recently, there has been much speculation regarding the role of cyclooxygenase-2 (COX-2) suppression in chemoprevention. Drugs with the ability to inhibit COX-2 expression include aspirin, nonsteroidal anti-inflammatory drugs (NSAID) and selective COX-2 inhibitors. Any strategy for chemoprevention must be able to quantify how effective the potential treatment is likely to be and which drugs will be most useful. We would also need to know for how long the agent could be taken safely and if any side-effects could preclude long-term use. Evidence from observational studies and recent updates of randomised controlled trials have been very encouraging - at least indicating benefit from the long term use of aspirin, even at low dose, with greatest impact on prevention of proximal colon cancers and adenomas. Most studies do, however, also warn that risks of gastrointestinal bleeding increase with long-term use of aspirin and related drugs. The risk-to-benefit ratio of a chemoprevention regimen using these medications needs to be carefully examined.
Control of Resistant Pink Bollworm ( <i>Pectinophora gossypiella</i> ) by Transgenic Cotton That Produces <i>Bacillus thuringiensis</i> Toxin Cry2Ab (2002)

Crops genetically engineered to produce Bacillus thuringiensis toxins for insect control can reduce use of conventional insecticides, but insect resistance could limit the success of this technology. The first generation of transgenic cotton with B. thuringiensis produces a single toxin, Cry1Ac, that is highly effective against susceptible larvae of pink bollworm (Pectinophora gossypiella), a major cotton pest. To counter potential problems with resistance, second-generation transgenic cotton that produces B. thuringiensis toxin Cry2Ab alone or in combination with Cry1Ac has been developed. In greenhouse bioassays, a pink bollworm strain selected in the laboratory for resistance to Cry1Ac survived equally well on transgenic cotton with Cry1Ac and on cotton without Cry1Ac. In contrast, Cry1Ac-resistant pink bollworm had little or no survival on second-generation transgenic cotton with Cry2Ab alone or with Cry1Ac plus Cry2Ab. Artificial diet bioassays showed that resistance to Cry1Ac did not confer strong cross-resistance to Cry2Aa. Strains with >90% larval survival on diet with 10 microg of Cry1Ac per ml showed 0% survival on diet with 3.2 or 10 microg of Cry2Aa per ml. However, the average survival of larvae fed a diet with 1 microg of Cry2Aa per ml was higher for Cry1Ac-resistant strains (2 to 10%) than for susceptible strains (0%). If plants with Cry1Ac plus Cry2Ab are deployed while genes that confer resistance to each of these toxins are rare, and if the inheritance of resistance to both toxins is recessive, the efficacy of transgenic cotton might be greatly extended.
Approximation algorithms for two optimal location problems in sensor networks (2005)

This paper study two problems that arise in optimization of sensor networks: First, we devise provable approximation schemes for locating a base station and constructing a network among a set of sensors each of which has a data stream to get to the base station. Subject to power constraints at the sensors, our goal is to locate the base station and establish a network in order to maximize the lifespan of the network. Second, we study optimal sensor placement problems for quality coverage of given domains cluttered with obstacles. We assume "line-of-site", sensors, that sense a point only if the straight segment connecting the sensor to this point (the "line-of-site") does not cross any obstacle. so obstacles occludes area from using line-of-site sensors, the goal is to minimize the number of sensors required in order to have each point "well covered" according to precise criteria (e.g., that each point is seen by two sensors that form at least angle a, or that each point is seen by three sensors that form a triangle containing the point).
Technical Drawing and Geometry (1976)

The circle features a great deal in building, especially in carpentry and joinery. The circle was partially covered in volume 1. To revise the characteristics of the circle, figure 21.1 shows the linear characteristics (radius, chord, normal, etc.) and figure 21.2 shows the area characteristics (quadrant, segment and sector).
Multi–Detector Row CT Urography: Comparison of Strategies for Depicting the Normal Urinary Collecting System (2002)

CT urography with a multi-detector row scanner and supplemental infusion of normal saline reliably displays the opacified urinary collecting system.
THERMOSETTING ACRYLIC RESINS Introduction (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHERMOSETTING ACRYLIC RESINS IntroductionHoward GerhartCite this: Ind. Eng. Chem. 1961, 53, 6, 458–459Publication Date (Print):June 1, 1961Publication History Published online1 May 2002Published inissue 1 June 1961https://pubs.acs.org/doi/10.1021/ie50618a028https://doi.org/10.1021/ie50618a028research-articleACS PublicationsRequest reuse permissionsArticle Views531Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Multiple Auditory Steady-state Responses (MASTER): Stimulus and Recording Parameters (1998)

Steady-state responses evoked by simultaneously presented amplitude-modulated tones were measured by examining the spectral components in the recording that corresponded to the different modulation frequencies. When using modulation frequencies between 70 and 110 Hz and an intensity of 60 dB SPL, there were significant interactions between two stimuli when the carrier frequencies were closer than one half of an octave apart, with attenuation of the response to the lower carrier frequency. However, there were no significant decreases in response amplitude with four simultaneous stimuli provided the carrier frequencies differed by one octave or more. Higher intensities (70 dB SPL) resulted in greater interactions between the stimuli than when low intensities (35 dB SPL) were used. Modulation frequencies could be as closely spaced as 1.3 Hz without affecting the responses. Using broad-band noise as a carrier instead of a pure tone resulted in a significantly larger response when the stimuli were presented at the same sound pressure level. At modulation frequencies between 30 and 50 Hz, there were greater interactions between stimuli than at faster modulation frequencies. These results support the following recommendations for using multiple stimuli in evoked potential audiometry: (1) The multiple stimulus technique works well for steady state responses at frequencies between 70 and 110 Hz. (2) Up to four stimuli can be simultaneously presented to an ear without significant loss in amplitude of the response, provided the carrier frequencies are separated by an octave and the intensities are 60 dB SPL or less. (3) Bandpass noise might serve as a better carrier signal than pure tones.
Role of prostaglandin E2 in the synthesis of the pro‐inflammatory cytokine interleukin‐6 in primary sensory neurons: an <i>in vivo</i> and <i>in vitro</i> study (2011)

Following various types of nerve injury, cyclooxygenase 2 and prostaglandin E2 (PGE2) are universally and chronically up-regulated in injured nerves and contribute to the genesis of neuropathic pain. Persistent high levels of PGE2 likely exert chronic effects on nociceptive dorsal root ganglion (DRG) neurons. In the present study, we tested the hypothesis that injured nerve-derived PGE2 contributes to the up-regulation of the pro-inflammatory cytokine interleukin-6 (IL-6) in DRG neurons following partial sciatic nerve ligation. In naive adult rats, IL-6 was expressed in only a few small size DRG neurons which all co-expressed EP4 receptors. Partial sciatic nerve ligation increased and shifted IL-6 expression from small to medium and large size damaged DRG neurons. Perineural injection of a selective cyclooxygenase 2 inhibitor or a selective EP4 receptor antagonist significantly suppressed the up-regulation of IL-6 in DRG, suggesting that injured nerve derived PGE2 contributes to the de novo synthesis of IL-6 in DRG neurons through EP4 receptors. In cultured sensory ganglion explants, a stabilized PGE2 analog increased IL-6 mRNA and protein levels through the activation of EP4, protein kinase A, protein kinase C, extracellular regulated protein kinase/MAPK, cAMP response element binding protein and NFκB signalling pathways. Taken together, these data indicate that facilitating the de novo synthesis of pain-related cytokines in injured medium and large size DRG neurons is a novel mechanism underlying the role of injured nerve derived PGE2 in the genesis of neuropathic pain.
Amphetamine: Effects on Catecholamine Systems and Behavior (1993)

Due to the massive data sets available for drug candidates, modern drug discovery has advanced to the big data era. Central to this shift is the development of artificial intelligence approaches to implementing innovative modeling based on the dynamic, ...Read More
Fe/Ni Metal–Organic Frameworks and Their Binder-Free Thin Films for Efficient Oxygen Evolution with Low Overpotential (2016)

Multivariate metal-organic frameworks with active Fe/Ni building blocks that are spatially arranged in an open structure are synthesized and explored for oxygen evolution reaction. The heterogeneity and porosity of this system prove to show synergy effect and give low onset overpotential at 170 mV. These MOFs are further fabricated into thin films over nickel foam by controlled electrochemical deposition to improve the surface conductivity and the overall stability. The Fe/Ni metal-organic framework film exhibits outstanding electrocatalytic activity with low overpotential of 270 mV at 10 mA cm(-2), small Tafel slope, high Faradaic efficiency, high turnover frequency, and great stability.
BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site (1999)

BRCA1 is a cell cycle-regulated nuclear protein that is phosphorylated mainly on serine and to a lesser extent on threonine residues. Changes in phosphorylation occur in response to cell cycle progression and DNA damage. Specifically, BRCA1 undergoes hyperphosphorylation during late G1 and S phases of the cell cycle. Here we report that BRCA1 is phosphorylated in vivo at serine 1497 (S1497), which is part of a cyclin-dependent kinase (CDK) consensus site. S1497 can be phosphorylated in vitro by CDK2-cyclin A or E. BRCA1 coimmunoprecipitates with an endogenous serine-threonine protein kinase activity that phosphorylates S1497 in vitro. This cellular kinase activity is sensitive to transfection of a dominant negative form of CDK2 as well as the application of the CDK inhibitors p21 and butyrolactone I but not p16. Furthermore, BRCA1 coimmunoprecipitates with CDK2 and cyclin A. These results suggest that the endogenous kinase activity is composed of CDK2-cyclin complexes, at least in part, concordant with the G1/S-specific increase in BRCA1 phosphorylation.
One microgram is the lowest ACTH dose to cause a maximal cortisol response. There is no diurnal variation of cortisol response to submaximal ACTH stimulation (1997)

There are many suggestions in the literature that the adrenal gland is more sensitive to ACTH in the evening than in the morning. However, all these studies in humans were conducted when the basal cortisol level was not suppressed, and were based on the observation that, after stimulation, the increases in cortisol differed, though the peak values were the same. To examine this, we established the lowest ACTH dose that caused a maximal cortisol stimulation even when the basal cortisol was suppressed, and used a smaller dose of ACTH for morning and evening stimulation. The lowest ACTH dose to achieve maximal stimulation was found to be 1.0 microgram, with which dose cortisol concentration increased to 607.2 +/- 182 nmol/l, compared with 612.7 +/- 140.8 nmol/l with the 250 micrograms test (P > 0.3). The use of smaller doses of ACTH (0.8 and 0.6 microgram) achieved significantly lower cortisol responses (312 +/- 179.4 and 323 +/- 157.3 nmol/l respectively; both P < 0.01 compared with the 1 microgram test). When a submaximal ACTH dose (0.6 microgram) was used to stimulate the adrenal at 0800 and 1600 h, after pretreatment with dexamethasone, no difference in response was noted at either 15 min (372.6 +/- 116 compared with 394.7 +/- 129.7 nmol/l) or 30 min (397.4 +/- 176.6 compared with 403 +/- 226.3 nmol/l; P > 0.3 for both times). These results show that 1.0 microgram ACTH, used latterly as a low-dose test, is very potent in stimulating the adrenal, even when baseline cortisol is suppressed; smaller doses cause reduction of this potency. Our data show that there is probably no diurnal variation in the response of the adrenal to ACTH, if one eliminates the influence of the basal cortisol level and uses physiologic rather than superphysiologic stimuli.
Fiber-optic displacement sensor based on the DBR fiber laser (2013)

The fiber-optic displacement sensor based on the distributed Bragg reflector fiber laser is proposed, that is, the fiber laser cavity is attached to the measured object, when the measured object is stretched or contracted, and the length of the fiber laser cavity is also stretched or contracted accordingly. In view of the nonlinearity of the fiber-optic displacement sensor, the calibration based on piezoelectric ceramics is applied to improve the linearity of the displacement sensor. Experiment results show that the fiber-optic displacement sensor has a linear response with the nominal working distance of 90 μm.
Terbutaline and Associated Risks for Neurodevelopmental Disorders (2014)

Preterm labor often leads to a preterm birth and has been shown to be the most important determinant of risk for perinatal morbidity and mortality. While medication management has been utilized by physicians to delay preterm labor, the results these medications achieve remain inconsistent, in addition to increasing the risk to the developing fetus. Terbutaline has been among the most commonly used <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-adrenoreceptor (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:msub><mml:mrow><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>AR) agonists in the management of preterm labor. The research suggests that tocolytic terbutaline therapy carries a significant risk for the mother and the child, which can be magnified by extended exposure, sex of the fetus, and administration during critical fetal developmental periods. This paper highlights the research on terbutaline in treatment of preterm labor, along with the possible associated cognitive deficits in adolescents who were treated with terbutaline in utero. Two case summaries are presented to illustrate the potential deficits in clinical presentations of adolescents with history of intrauterine exposure to terbutaline. Publicizing the association between terbutaline and these deficits can not only assist obstetricians and expectant mothers in making a more informed choice in the treatment of preterm labor but also provide neuropsychologists and pediatricians with information helpful in understanding the etiology of these impairments.
Depletion of Tregs for Adoptive T-cell Therapy Using CD44 and CD137 as Selection Markers (2012)

Several types of cancer have been shown to be susceptible to cellular immune responses, leading to investigations using various forms of T cell-based, tumor-directed immunotherapy. One potential obstacle for the successful application of these therapies is the suppressive function of Tregs. Goldstein and colleagues evaluate a strategy to identify and remove Tregs from an adoptive T-cell therapy product generated by in vivo vaccination. They demonstrate that the depletion of Tregs characterized by CD44 and CD137 expression enhances antitumor immunity in their mouse model.
文化、阶级和教育——剖析英国困境 (1985)

英国知名学者、中国问题专家罗德里克·麦克法戈教授,多年从事学术研究、政党和新闻工作,原为工党议员,现为社会民主党党员。他于1984年7月中旬访华期间所作的演讲《文化、阶级与教育:剖析英国困境》,介绍了英国的历史传统和现实情况,现将译文摘要发表如下。
<i>Streptococcus pneumoniae</i>Protein Vaccine Candidates: Properties, Activities and Animal Studies (2006)

Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.
Schottky diode-based mixers design and optimization at millimetre and submillimetre-wave bands (2005)

In this paper we present some design and optimization aspects for Schottky-based mixers at the millimetre and submillimetre-wave bands by using an in-house mixer CAD tool. This simulator takes into account both the external circuit and a physical model for the semiconductor device. For mixer analysis, proper time-frequency conversion techniques have been implemented, which combine good accuracy and low computational cost. This CAD tool allows the joint optimization of the Schottky diode and the external circuit. Another important advantage is the possibility to study and optimize the internal structure of the Schottky diode for optimum performance.
Heptahelical Receptor Signaling: Beyond the G Protein Paradigm (1999)

Heptahelical receptors, so called because of their conserved structure featuring seven α-helical transmembrane spans, mediate physiological responses to a remarkably diverse array of stimuli. These include hormones, neurotransmitters, small peptides, proteins, lipids and ions, as well as sensory
Steer gains on burned and nonburned bluestem pasture and reimplanting with Ralgro at mid-summer (1981)

Steers on a late spring burned bluestem pasture gained 1.4 lbs daily during the summer compared with 1.0 lb. by steers on a nonburned pasture. All steers were implanted with Ralgro at the start of the grazing season (May 1) and half in each pasture were reimplanted July 15. Reimplanting did not affect weight gain.
Serum PAPP‐A and free β‐hCG are first‐trimester screening markers for down syndrome (1994)

Serum measurements of pregnancy-associated plasma protein A (PAPP-A) and the free beta-human chorionic gonadotrophin (hCG) subunit were made in 13 women with Down syndrome (DS) pregnancies and six other women with fetal aneuploidy ascertained at chorionic villus sampling (CVS), as well as 89 women with contemporaneous normal control pregnancies. Median serum PAPP-A measurements (0.31 MOM, 95 per cent confidence interval (CI) 0.22-0.65 vs. normal 1.06, 95 per cent CI 0.89-1.20) were lower and free beta-hCG subunit measurements (1.13 MOM, 95 per cent CI 0.93-2.63 vs. normal 0.91, 95 per cent CI 0.79-1.03) were higher at statistically significant levels. Receiver operator characteristics (ROC) curves showed that the highest sensitivity for detection, 71.2 per cent (95 per cent CI 54.7-87.6 per cent), was for depressed PAPP-A levels; the combination of low serum PAPP-A levels, maternal age, and elevated free beta-hCG levels yielded a detection rate of 78.9 per cent (95 per cent CI 64.9-92.8 per cent) of the affected pregnancies at 8-12 weeks' gestation.
Improving assessment of daily energy expenditure by identifying types of physical activity with a single accelerometer (2009)

Accelerometers are often used to quantify the acceleration of the body in arbitrary units (counts) to measure physical activity (PA) and to estimate energy expenditure. The present study investigated whether the identification of types of PA with one accelerometer could improve the estimation of energy expenditure compared with activity counts. Total energy expenditure (TEE) of 15 subjects was measured with the use of double-labeled water. The physical activity level (PAL) was derived by dividing TEE by sleeping metabolic rate. Simultaneously, PA was measured with one accelerometer. Accelerometer output was processed to calculate activity counts per day (AC(D)) and to determine the daily duration of six types of common activities identified with a classification tree model. A daily metabolic value (MET(D)) was calculated as mean of the MET compendium value of each activity type weighed by the daily duration. TEE was predicted by AC(D) and body weight and by AC(D) and fat-free mass, with a standard error of estimate (SEE) of 1.47 MJ/day, and 1.2 MJ/day, respectively. The replacement in these models of AC(D) with MET(D) increased the explained variation in TEE by 9%, decreasing SEE by 0.14 MJ/day and 0.18 MJ/day, respectively. The correlation between PAL and MET(D) (R(2) = 51%) was higher than that between PAL and AC(D) (R(2) = 46%). We conclude that identification of activity types combined with MET intensity values improves the assessment of energy expenditure compared with activity counts. Future studies could develop models to objectively assess activity type and intensity to further increase accuracy of the energy expenditure estimation.