gebhart/patrepeval huggingface dataset:
Unified Detection and Tracking of Instruments during Retinal Microsurgery (2012)

Methods for tracking an object have generally fallen into two groups: tracking by detection and tracking through local optimization. The advantage of detection-based tracking is its ability to deal with target appearance and disappearance, but it does not naturally take advantage of target motion continuity during detection. The advantage of local optimization is efficiency and accuracy, but it requires additional algorithms to initialize tracking when the target is lost. To bridge these two approaches, we propose a framework for unified detection and tracking as a time-series Bayesian estimation problem. The basis of our approach is to treat both detection and tracking as a sequential entropy minimization problem, where the goal is to determine the parameters describing a target in each frame. To do this we integrate the Active Testing (AT) paradigm with Bayesian filtering, and this results in a framework capable of both detecting and tracking robustly in situations where the target object enters and leaves the field of view regularly. We demonstrate our approach on a retinal tool tracking problem and show through extensive experiments that our method provides an efficient and robust tracking solution.
Dupilumab facial redness: Clinical characteristics and proposed treatment in a cohort (2021)

In this case series, we report for the first time in the literature in a cohort, the positive response to oral or topical antifungals for atopic dermatitis patients treated with Dupilumab that developed Dupilumab facial redness, supporting the Malassezia hypersensitivity theory.
Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects (2011)

This is the first extensive study to compare bacterial counts from culture-dependent microbiological techniques and from next generation sequencing technologies.
Role of Protein Kinase C in Neuroprotective Effect of Geranylgeranylacetone, a Noninvasive Inducing Agent of Heat Shock Protein, on Delayed Neuronal Death Caused by Transient Ischemia in Rats (2006)

We evaluated the neuroprotective effect of geranylgeranylacetone (GGA), an antiulcer agent and inducing agent of heat-shock protein (HSP), against the delayed death of hippocampal neurons induced by transient bilateral occlusion of the common carotid artery (CCA) and hypotension (40 mm Hg) lasting for 10 min. To test the hypothesis that orally administered GGA would induce protein kinase C (PKC), leading to the expression of HSP70 and protection against delayed neuronal death (DND), we gave GGA orally to rats in various regimens prior to bilateral occlusion of the CCA, and quantitatively assessed the extent of DND in region CA1 of the hippocampus at 7 days after transient ischemia. Pretreatment with a single oral dose of GGA of 800 mg/kg at 48 h before ischemia significantly attenuated DND (20.0 +/- 3.81 vs. 321.0 +/- 11.01 mm(3); p < 0.05). A similar degree of neuron sparing occurred when GGA was given 2, 4, or 8 days before ischemia. These neuroprotective effects of GGA were prevented by pretreatment with chelerythrine (CHE), a specific inhibitor of PKC, indicating that PKC may mediate GGA-dependent protection against ischemic DND. Oral GGA-induced expression of HSP70 elicited the expression of PKCdelta, and pretreatment with GGA enhanced the ischemia-induced expression of HSP70, both of which effects were prevented by pretreatment with CHE. These results suggest that a single oral dose of GGA induces the expression of PKCdelta and promotes the expression of HSP70 in the brain, and that GGA plays an important role in neuroprotection against DND. Pretreatment with a single oral dose of GGA provides an important tool for exploring the mechanisms of neuroprotection against DND of hippocampal neurons after transient ischemia.
Functionality directed clustering for low power MTCMOS design (2005)

Multi-Threshold CMOS (MTCMOS) is a circuit style that can effectively reduce leakage power consumption. Sleep transistor sizing is the key issue when MTCMOS circuit is designed. If the sleep transistor size is too large, the circuit performance can be maintained but the dynamic power consumption of the sleep transistor will increase. On the other hand, if the sleep transistor size is too small, there will be significant performance degradation because of the increased resistance to ground. Previous approach [1, 2] designed the sleep transistor size based on mutual exclusive discharge patterns. However, these approaches considered only topology of a circuit. We observed that two possible simultaneous switching gates may not discharge at the same time in terms of functionality. Thus, we propose an algorithm to determine how to cluster cells to share sleep transistors taking both topology and functionality into consideration. The results show that the proposed method can achieve on the average 18% reduction ratio in terms of the number of sleep transistors as compared to the method without considering functionality.
Superconducting thin-film multiturn coils of YBa2Cu3O7−<i>x</i> (1990)

We describe a technique for fabricating superconducting thin-film multiturn coils from the high-temperature superconductor YBa2Cu3O7−x. We have built 10-turn and 19-turn square spiral coils, 1 mm on a side, that are suitable for coupling to a thin-film dc superconducting quantum interference device. The coils are constructed with a three-layer crossover technology using SrTiO3 as an insulator. Each layer is deposited in situ with a pulsed excimer laser, and is patterned with shadow masks or photoresist and an Ar ion mill. The best coil had a transition temperature of approximately 82 K, and a critical current at 77 K of 1.4 mA, corresponding to a critical current density of 2×104 A cm−2.
Combined pericarditis and pneumonia caused by Legionella infection. (1987)

During a one year period acute pericarditis was diagnosed in 16 consecutive patients without acute infarction or malignancy. In two of these patients with both pericarditis and pneumonia Legionella infection was present. One case was caused by Legionella longbeachae and the other by both Legionella longbeachae and Legionella jordanis. When pericarditis is associated with pneumonia Legionella infection should be sought so that effective treatment with erythromycin may be started early.
Coordination Polymers Versus Metal−Organic Frameworks (2009)

Different terminologies such as coordination polymers, metal−organic frameworks, and hybrid inorganic and organic framework materials have been used to describe the nonmolecular or extended solid-state structures containing metal ions and organic spacer ligands. In this perspective, we discuss its origin as well as the pros and cons of using these terminologies in the literature.
A turbo-driven known-modulus blind equalization method (2004)

We describe and demonstrate a new turbo-driven blind equalization and decoding method that generates and exploits modulus information obtained initially by using a blind equalizer and a soft-input soft-output decoder. The method is turbo-like in that information is extracted from the equalizer and decoder outputs and then used in subsequent iterations, but it is less computationally complex than true turbo equalization. Compared with existing blind and nonblind turbo methods, the new methods easily accommodate fractionally-spaced equalizers, they can potentially be implemented in a fully blind manner, and they accommodate larger constellations and longer channels.
Registration using natural features for augmented reality systems (2006)

Registration is one of the most difficult problems in augmented reality (AR) systems. In this paper, a simple registration method using natural features based on the projective reconstruction technique is proposed. This method consists of two steps: embedding and rendering. Embedding involves specifying four points to build the world coordinate system on which a virtual object will be superimposed. In rendering, the Kanade-Lucas-Tomasi (KLT) feature tracker is used to track the natural feature correspondences in the live video. The natural features that have been tracked are used to estimate the corresponding projective matrix in the image sequence. Next, the projective reconstruction technique is used to transfer the four specified points to compute the registration matrix for augmentation. This paper also proposes a robust method for estimating the projective matrix, where the natural features that have been tracked are normalized (translation and scaling) and used as the input data. The estimated projective matrix will be used as an initial estimate for a nonlinear optimization method that minimizes the actual residual errors based on the Levenberg-Marquardt (LM) minimization method, thus making the results more robust and stable. The proposed registration method has three major advantages: 1) It is simple, as no predefined fiducials or markers are used for registration for either indoor and outdoor AR applications. 2) It is robust, because it remains effective as long as at least six natural features are tracked during the entire augmentation, and the existence of the corresponding projective matrices in the live video is guaranteed. Meanwhile, the robust method to estimate the projective matrix can obtain stable results even when there are some outliers during the tracking process. 3) Virtual objects can still be superimposed on the specified areas, even if some parts of the areas are occluded during the entire process. Some indoor and outdoor experiments have been conducted to validate the performance of this proposed method.
No Relation between Physical Disability Scores and Severity of PBA in MS (2012)

Pseudobulbar affect (PBA) is a neurological condition of disinhibition of emotional expression characterized by uncontrollable, exaggerated, and often inappropriate outbursts of laughter and/or crying that may cause severe distress, embarrassment, and social dysfunction. This article discusses results from a study to examine the relationships between physical disability and the severity of PBA in patients with underlying multiple sclerosis.
Infinite time-evolving block decimation algorithm beyond unitary evolution (2008)

The infinite time-evolving block decimation algorithm [G. Vidal, Phys. Rev. Lett. 98, 070201 (2007)] allows to simulate unitary evolution and to compute the ground state of one-dimensional (1D) quantum lattice systems in the thermodynamic limit. Here we extend the algorithm to tackle a much broader class of problems, namely, the simulation of arbitrary one-dimensional evolution operators that can be expressed as a (translationally invariant) tensor network. Relatedly, we also address the problem of finding the dominant eigenvalue and eigenvector of a one-dimensional transfer matrix that can be expressed in the same way. New applications include the simulation, in the thermodynamic limit, of open (i.e., master equation) dynamics and thermal states in 1D quantum systems, as well as calculations with partition functions in two-dimensional (2D) classical systems, on which we elaborate. The present extension of the algorithm also plays a prominent role in the infinite projected entangled-pair states approach to infinite 2D quantum lattice systems.
Trade and Border Security as Political Issues in Canada (2003)

On February 5, 2003 the Maine International Trade Center and University of Maine Canadian American Center co-sponsored a day-long forum on the challenges and opportunities of free trade between Canada and the United States. In this article, edited from his presentation at this forum, Howard Cody begins with passage of the Free Trade Agreement and brings readers up to the present day, where trade and border security concerns have become inextricably combined. Cody argues that Canadians will not persuade Americans to distinguish between the two concerns and, consequently, that Canadians will eventually accept some sacrifice in national sovereignty in order to maintain the benefits of their current trade and investment relationship with the United States.
Optimal audio-visual representations for illiterate users of computers (2007)

We present research leading toward an understanding of the optimal audio-visual representation for illustrating concepts for illiterate and semi-literate users of computers. In our user study, which to our knowledge is the first of its kind, we presented to 200 illiterate subjects each of 13 different health symptoms in one representation randomly selected among the following ten: text, static drawings, staticphotographs, hand-drawn animations, and video, each with and without voice annotation. The goal was to see how comprehensible these representation types were for an illiterate audience. We used a methodology for generating each of the representations tested in a way that fairly stacks one representational type against the others.
Genetic Variation of an Odorant Receptor OR7D4 and Sensory Perception of Cooked Meat Containing Androstenone (2012)

Although odour perception impacts food preferences, the effect of genotypic variation of odorant receptors (ORs) on the sensory perception of food is unclear. Human OR7D4 responds to androstenone, and genotypic variation in OR7D4 predicts variation in the perception of androstenone. Since androstenone is naturally present in meat derived from male pigs, we asked whether OR7D4 genotype correlates with either the ability to detect androstenone or the evaluation of cooked pork tainted with varying levels of androstenone within the naturally-occurring range. Consistent with previous findings, subjects with two copies of the functional OR7D4 RT variant were more sensitive to androstenone than subjects carrying a non-functional OR7D4 WM variant. When pork containing varying levels of androstenone was cooked and tested by sniffing and tasting, subjects with two copies of the RT variant tended to rate the androstenone-containing meat as less favourable than subjects carrying the WM variant. Our data is consistent with the idea that OR7D4 genotype predicts the sensory perception of meat containing androstenone and that genetic variation in an odorant receptor can alter food preferences.
Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles (2018)

Silicon-containing compounds have been largely ignored in drug design and development, despite their potential to improve not only the potency but also the physicochemical and ADMET ( absorption, distribution, metabolism, excretion, toxicity) properties of drug-like candidates because of the unique characteristics of silicon. This deficiency is in large part attributable to a lack of general methods for synthesizing diverse organosilicon structures. Accordingly, a new building block strategy has been developed that diverges from traditional approaches to incorporation of silicon into drug candidates. Flexible, multi-gram-scale syntheses of silicon-containing tetrahydroquinoline and tetrahydroisoquinoline building blocks are described, along with methods by which diversely functionalized silicon-containing nitrogen heterocycles can be rapidly built using common reactions optimized to accommodate the properties of silicon. Furthermore, to better clarify the liabilities and advantages of silicon incorporation, select compounds and their carbon analogues were challenged in ADMET-focused biological studies.
Microporous polypropylene sheets containing CaCO<sub>3</sub> filler (1993)

Abstract Biaxial stretching of polypropylene sheets containing CaCO 3 filler results in microporous sheets, that feel soft and dry. Their properties depend on filler content, particle size of the filler, and stretching degree etc. We have studied the dependency of some properties of the microporous polypropylene sheets on stretching degree. It is elucidated that mechanical properties are controllable by adjusting stretching degrees in machine and transverse directions. © 1993 John Wiley & Sons, Inc.
Oligomerization and Trafficking of the Human Dopamine Transporter (2003)

The dopamine transporter (DAT) is a presynaptic plasma membrane protein responsible for the termination of dopaminergic neurotransmission in the central nervous system. While most studies have focused on structure/function analysis, much less information is available regarding the assembly and the trafficking of this protein. To address this problem, we performed a mutational analysis of the DAT protein, combined with biochemical, immunological, and functional approaches. In mammalian cells co-expressing differentially tagged DAT molecules, HA-tagged DAT co-purified with 6His-tagged DAT demonstrating a physical interaction between transporter proteins. Evidence for the functional oligomerization of DAT was obtained using dominant-negative mutants of DAT. Two loss-of-function mutant transporters (Y335A and D79G) that were targeted to the cell surface inhibited wild-type DAT uptake activity without affecting the membrane targeting of the wild-type transporter. Moreover, non-functional amino and carboxyl termini-truncated mutants of DAT inhibited wild-type DAT function by interfering with the normal processing of the wild-type transporter to the cell membrane. Mutations in the leucine repeat of the second transmembrane domain of the transporter could eliminate the dominant-negative effect of all these mutants. In addition, a small fragment comprising the first two transmembrane domains of DAT inhibited wild-type transporter function but not when the leucine repeat motif was mutated. Taken together, our results suggest that the assembly of DAT monomers plays a critical role in the expression and function of the transporter.
Analysis of a device for converting a unipolar input voltage into two symmetric bidirectional output voltages with a magnetically coupled coil (2008)

A new principle of a DC-DC converter with a magnetic coupled coil is analyzed. The speciality of this converter is that it transforms a unipolar input voltage into two symmetrical bidirectional DC voltages with only one power switch. The value of the output voltage can be varied by the duty cycle of the switch. The generation of two symmetrical voltages, one positive and one negative related to ground, makes it possible to invert a DC voltage to a single phase AC network with only three switches. For the operation of a class-D amplifier, for multi quadrant operation of DC motors or actuators a symmetrical bidirectional supply voltage can also be very useful. After basic analysis in continuous inductor current mode, dimensioning of the converter components, a state space model and linearized transfer functions for the control of the converter are derived.
Language Learning strategies and foreign language achievement (2003)

This paper invesligates le relationship betsveen language learning strategies and foreign language achievement.Language leaming slrategies were measured by the Strategy Inventoy for Language Leaming (SILL, 7.0 ESL/EFL Version), and the foreign language achievement was determincd using the mid-semestcr course grade averages for 21 ELT studenls attending the English Preparatory ctass of the ELT Department.The findings of le study are: (1) the relationship betvvccn language leaming strategies and foreign language achievement was lincar, (2) among the categories included in the inventory only compensation for missing knosvledge and the total language learning strategies were signiiicantly conelated with Ile foreign language achievement as measured by the mid-semester course grade averages and (3) among the categories only compcnsating for the missing knowledge was predietive of the foreign language achievement accounting for 21 percent o f the total varialion in the achievement scoes.
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent‐onset rheumatoid arthritis (2007)

This study established a model for predicting the efficacy of MTX in patients with RA. This pharmacogenetic model may lead to better-tailored initial treatment decisions in patients with RA.
Nephila clavipes Flagelliform Silk-Like GGX Motifs Contribute to Extensibility and Spacer Motifs Contribute to Strength in Synthetic Spider Silk Fibers (2013)

Flagelliform spider silk is the most extensible silk fiber produced by orb weaver spiders, though not as strong as the dragline silk of the spider. The motifs found in the core of the Nephila clavipes flagelliform Flag protein are GGX, spacer, and GPGGX. Flag does not contain the polyalanine motif known to provide the strength of dragline silk. To investigate the source of flagelliform fiber strength, four recombinant proteins were produced containing variations of the three core motifs of the Nephila clavipes flagelliform Flag protein that produces this type of fiber. The as-spun fibers were processed in 80% aqueous isopropanol using a standardized process for all four fiber types, which produced improved mechanical properties. Mechanical testing of the recombinant proteins determined that the GGX motif contributes extensibility and the spacer motif contributes strength to the recombinant fibers. Recombinant protein fibers containing the spacer motif were stronger than the proteins constructed without the spacer that contained only the GGX motif or the combination of the GGX and GPGGX motifs. The mechanical and structural X-ray diffraction analysis of the recombinant fibers provide data that suggests a functional role of the spacer motif that produces tensile strength, though the spacer motif is not clearly defined structurally. These results indicate that the spacer is likely a primary contributor of strength, with the GGX motif supplying mobility to the protein network of native N. clavipes flagelliform silk fibers.
Wide-field axial plane optical microscopy (2014)

We present axial plane optical microscopy (APOM) that enables wide-field imaging of samples along an axial plane perpendicular to the focal plane of the microscope’s objective lens. APOM utilizes optical remote focusing with a tilted mirror to achieve aberration-free axial imaging with no scanning units. We predict APOM’s theoretical resolution and experimentally demonstrate APOM images of biological samples: fluorescent pollen grains and mouse brain slides.
Fusion of Cyclophilin A to Fv1 Enables Cyclosporine-Sensitive Restriction of Human and Feline Immunodeficiency Viruses (2007)

TRIM5alpha is a potent intracellular antiviral restriction factor governing species-specific retroviral replication. In the New World species owl monkey the coding region for the viral binding B30.2 domain of TRIM5alpha has been replaced by a cyclophilin A (CypA) pseudogene by retrotransposition. The resultant TRIM5-CypA fusion protein restricts human immunodeficiency virus type 1 (HIV-1), as well as feline immunodeficiency virus (FIV), by recruitment of the CypA domain to the incoming viral capsids. Infectivity is rescued by agents such as cyclosporine that disrupt CypA binding to its substrates. Mice encode an antiviral restriction factor called Fv1 (for Friend virus susceptibility gene 1), which is active against murine leukemia virus and related to endogenous gag sequences. Here we show that fusing CypA to Fv1 generates a restriction factor with the antiviral specificity of TRIMCyp but the antiviral properties of Fv1. Like TRIMCyp, Fv1-Cyp restricts HIV-1 and FIV and is sensitive to inhibition by cyclosporine. TRIM5alpha is known to have a short half-life and block infectivity before viral reverse transcription. We show that Fv1-Cyp has a long half-life and blocks after reverse transcription, suggesting that its longer half-life gives the restricted virus the opportunity to synthesize DNA, leading to a later block to infection. This notion is supported by the observation that infectivity of Fv1-Cyp restricted virus can be rescued by cyclosporine for several hours after infection, whereas virus restricted by TRIMCyp is terminally restricted after around 40 min. Intriguingly, the Fv1-Cyp-restricted HIV-1 generates closed circular viral DNA, suggesting that the restricted virus complex enters the nucleus.