gebhart/patrepeval huggingface dataset:
Epithelium of mouse yolk sac placenta lacks H-2 complex alloantigens. (1980)

The only fetal cell membrane exposed to the mother in the mouse yolk sac placenta is the apical membrane of the endodermal epithelial cells. In yolk sac preparations in vitro, this apical membrane was exposed to reagents or cells in the incubation medium. By using several techniques we were not able to detect fetal major histocompatibility complex (MHC) antigens in this membrane. Immunoferritin labeling with and without prefixation and after neurominidase and trypsin digestion indicated that the apical membrane could contain no more than approximately 1% of the H-2 complex antigens that were present on peritoneal macrophages. Incubation of yolk sac preparations in anti-H-2 complex antiserum and complement had no cytotoxic effect on the endodermal epithelium, nor did incubation in an excess of alloreactive lymphocytes. Dissociated preparations of prefixed yolk sac contained endodermal epithelial cells and vascular endothelial cells whose entire surface membranes were exposed to the medium. H-2-complex antigens were not detected by immunoferritin labeling in either the apical or the laterobasal membrane of the yolk sac endoderm, but they were present in low density on the vascular endothelium. Also, incubation of unfixed, dissociated cells in anti-H-2-complex serum and complement had no detectable cytotoxic effect on endodermal epithelial cells. These observations indicate that H-2 antigens are sparse or absent in both the apical and laterobasal membranes of endodermal epithelial cells. The deficiency of MHC antigens in the apical membrane may account for the failure of sensitized females to reject the yolk sac, whereas the composition of the laterobasal membrane is probably less important to maternal-fetal relations. The present observations are consistent with labeling studies of adult-lining epithelial cells, which indicate that self-marker MHC molecules are absent from the apical membranes oriented toward the outside world and variably expressed in the laterobasal self-side membranes. It is suggested that the corresponding exclusion of fetal self-marker molecules from the apical membranes of some kinds of placental epithelia would deprive the mother of target sites for an alloimmune reaction at the maternal-fetal interface.
Characteristics of <I>Cimex lectularius</I> (Hemiptera: Cimicidae), Infestation and Dispersal in a High-Rise Apartment Building (2010)

Bed bugs, Cimex lectularius L. (Hemiptera: Cimicidae), are a fast-growing urban pest of significant public health importance in the United States and many other countries. Yet, there is very little field research on the ecology of this pest due to its near absence in the United States and most developed nations for several decades. We investigated characteristics of the bed bug infestation and dispersal in a 223-unit high-rise apartment building through visual inspections, intercepting devices, and resident and staff interviews between December 2008 and April 2009. The following results were obtained: 1) 101 apartments (45% of the high-rise building complex) experienced bed bug infestations (within 41 mo of the first confirmed introduction), 2) 78% of the bed bugs trapped were nymphs, 3) an average of six bed bugs were detected dispersing through apartment entry doors every 4 wk, 4) adult bed bugs were 9 times more likely to disperse than nymphs, 5) 53% of apartments adjacent to infested apartments also were infested, and 6) 50% of the interviewed residents who had infestations were unaware of the bed bugs in their apartments. In addition to active dispersal, several passive bed bug dispersal mechanisms were observed: bringing bed bug-infested furniture into the building, travel, resident turnover, resident visits, and use of a bed bug-infested wheelchair in building common areas. These findings validate an urgent need for public education, early detection, and adoption of more effective bed bug monitoring and intervention programs to curb the exploding problem of bed bug infestations.
Revisiting the performance impact of branch predictor latencies (2006)

Branch predictors play a critical role in the performance of modern processors, and the prediction accuracy is known to be the most important attribute of such predictors. However, the latency of the predictor can also have a profound impact on performance as well. In past studies that have considered branch prediction latency, most only consider the latency required to make a prediction. However, in deeply pipelined processors, the latency between prediction and update can also greatly affect performance. In this study, we revisit the performance impact of both of these latencies and demonstrate that update latency can also have a significant impact on performance. We then describe two techniques, multi-overriding and hierarchical updates, to address both latencies which provide 4.4% and 5.7% IPC improvements on moderately (20-stage) and deeply (40-stage) pipelined processors, respectively, for minimal hardware complexity.
Thermoelectric power and conductivity of different types of polypyrrole (1999)

We have measured the thermoelectric power and conductivity as a function of temperature of a wide range of polypyrrole samples, including a film of soluble polypyrrole synthesized chemically, and wrinkled films synthesized using indium–tin oxide electrodes; other samples investigated include high-conductivity polypyrrole films synthesized at different temperatures and current densities, films grown on nonconducting substrates, and polypyrrole gas sensors. The thermoelectric powers are remarkably similar and metal-like for the medium and high conductivity samples but show nonzero extrapolations to zero temperature for wrinkled samples. The temperature dependence of conductivity tends to be greater for samples of lower conductivity. In contrast to polyaniline and polyacetylene, a crossover to metallic sign for the temperature dependence of conductivity at higher temperatures is not observed in any of our samples; the fluctuation-induced tunnelling and variable-range hopping expressions account for nearly all our conductivity data except for low-temperature anomalies. © 1999 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 37: 953–960, 1999
Time-Domain Parameter Extraction Method for Thévenin-Equivalent Circuit Battery Models (2014)

This paper presents an analytical time-domain-based parameter identification method for Thévenin-equivalent circuit-based lithium-ion battery models. The method is based on the analysis of voltage-relaxation characteristics of pulse discharge and pulse charge experiments, and the method can be used for both discharge and charge operation with any number of parallel resistor-capacitor branches. The use of the method is demonstrated for a second-order model and validated with a real-world duty cycle. Experimental results for a commercial lithium-ion battery module are presented.
Analysis of Aliphatic Per Acids (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of Aliphatic Per AcidsF. P. Greenspan and D. G. MacKellarCite this: Anal. Chem. 1948, 20, 11, 1061–1063Publication Date (Print):November 13, 1948Publication History Published online1 May 2002Published inissue 13 November 1948https://pubs.acs.org/doi/10.1021/ac60023a020https://doi.org/10.1021/ac60023a020research-articleACS PublicationsRequest reuse permissionsArticle Views1200Altmetric-Citations184LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of inoculation with a thermotolerant plant growth promoting<i>Pseudomonas putida</i>strain AKMP7 on growth of wheat (<i>Triticum</i>spp.) under heat stress (2011)

The present study was carried out to investigate the effect of plant growth promoting thermotolerant Pseudomonas putida strain AKMP7 on the growth of wheat plants to heat stress. The results indicated the superior performance by P. putida strain AKMP7 in improving survival and growth of wheat plants under heat stress. The bacterium significantly increased the root and shoot length, dry biomass, tiller, spike let and grain formation of wheat over uninoculated plants. Inoculation reduced membrane injury and the activity of several antioxidant enzymes such as SOD, APX and CAT under heat stress. Inoculation improved the levels of cellular metabolites like proline, chlorophyll, sugars, starch, amino acids, and proteins compared to uninoculated plants. Scanning electron microscopy studies confirmed the colonization of the organism on the root surface. This result suggests the possible role of microorganisms in mitigating adverse effects of climate changes on crop growth and may lead to development of microbe based climate- ready technology.
FEM analysis of cylindrical resonant photoacoustic cells (2010)

Using a mathematical model on photoacoustics that includes both temperature and pressure effects explicitly, we analyze the behaviour of resonances of a cylindrical photoacoustic cell consisting of two buffer volumes and a resonator. We excite the cell at a certain frequency and find the ratio of resonator versus buffer diameter needed to obtain resonance. The results show that the resonance ratio depends on the absolute cell size. Also the amplitude of the acoustic signal measured in the middle of the resonator does not necessarily decrease when the total cell volume is increased. If the resonator diameter is sufficiently small, decreasing its diameter will increase the acoustic signal, although the total cell volume has to be increased to obtain resonance. This gives the advantage of being able to obtain a comparably large signal and at the same time use large buffer diameters to suppress window absorption signals. Finally we also compare the quality of the above-mentioned model and the lossy Helmholtz equation. We find that there is a shift in resonance ratio and the signal damping differs slightly. Albeit these differences are not large, and in many cases negligible, the model can be easily coupled with a solid absorption model in order to investigate the importance of thermal and pressure coupling between two acoustic media subject to heat absorption.
Gastrointestinal complications of laparoscopy sterilization. (1973)

The purpose of this study is to review the experience at the Johns Hopkins Hospital with gastrointestinal complications conincident with 3600 laparoscopic sterilizations done between the years 1968 and 1972. Patients' ages ranged from 13 to 48 years and parity 0 to 13. All patients, after giving histories, received physical examination, menatocrit, urinalysis, and Papanicolaou smears. 80% were outpatients. Inpatients had medical illnesses that required preoperative evaluation or had come from long distances. 18% had previous abdominal surgery, which was not considered a contraindication. The 2 incision laparoscope technic was used in the first series of about 1000 pateints. The 1 incision, one burn technic was used for the second series of 1000 patients. A third series of 1600 patients were operated on using a 3 burn modification of the 1 incision technic. Gastrointestinal complications are those noted in the first 30 days after surgery. In 5 patients electrocoagulated segment of the bowel was recognized at laparoscopy and the extent of the lesion less than .5 cm. Only 1 had immediate laparotomy, and experience shows perhaps she could have been treated expectantly. A second group of 5 gastrointestinal injuries, not recognized at surgery, were delayed bowel perforations due to electrocoagulation. All were readmitted from the third to the seventh day after the operation. All required laparotomy and resection of the perforated segment of the bowel, which was in the terminal ileum in all 5 cases. 3 recovered promptly, 2 had complicated recoveries with septic pelvic thrombophlebitis in 1. She was eventually discharged on the 32nd day. All perforations occurred opposite the mesenteric border and microscopic study confirmed the causes as thermal coagulation. Perforation size varied from .5 to 4 cm. 1 traumatic bowel injury occurred at the time of the insertion of laparoscope trocar. In this case the small bowel was adherent to the anterior abdominal wall following a previous laparotomy. Simple repair resulted in recovery. Complications were equally frequent with each technic. The 11 cases of gastrointestinal complication represent .3% of the 3600 operations. Laparotomy was required in .2%. Metal tubal clips applied with laparoscopy may replace electrocoagulation and thus reduce complications.
Extravascular CX3CR1<sup>+</sup>Cells Extend Intravascular Dendritic Processes into Intact Central Nervous System Vessel Lumen (2013)

Within the central nervous system (CNS), antigen-presenting cells (APCs) play a critical role in orchestrating inflammatory responses where they present CNS-derived antigens to immune cells that are recruited from the circulation to the cerebrospinal fluid, parenchyma, and perivascular space. Available data indicate that APCs do so indirectly from outside of CNS vessels without direct access to luminal contents. Here, we applied high-resolution, dynamic intravital two-photon laser scanning microscopy to directly visualize extravascular CX3CR1+ APC behavior deep within undisrupted CNS tissues in two distinct anatomical sites under three different inflammatory stimuli. Surprisingly, we observed that CNS-resident APCs dynamically extend their cellular processes across an intact vessel wall into the vascular lumen with preservation of vessel integrity. While only a small number of APCs displayed intravascular extensions in intact, noninflamed vessels in the brain and the spinal cord, the frequency of projections increased over days in an experimental autoimmune encephalomyelitis model, whereas the number of projections remained stable compared to baseline days after tissue injury such as CNS tumor infiltration and aseptic spinal cord trauma. Our observation of this unique behavior by parenchyma CX3CR1+ cells in the CNS argues for further exploration into their functional role in antigen sampling and immune cell recruitment.
Connecting orbits and invariant manifolds in the spatial restricted three-body problem (2004)

The invariant manifold structures of the collinear libration points for the restricted three-body problem provide the framework for understanding transport phenomena from a geometrical point of view. In particular, the stable and unstable invariant manifold tubes associated with libration point orbits are the phase space conduits transporting material between primary bodies for separate three-body systems. These tubes can be used to construct new spacecraft trajectories, such as a ‘Petit Grand Tour’ of the moons of Jupiter. Previous work focused on the planar circular restricted three-body problem. \nThis work extends the results to the three-dimensional case. Besides providing a full description of different kinds of libration motions in a large vicinity of these points, this paper numerically demonstrates the existence of heteroclinic connections between pairs of libration orbits, one around the libration point L_1 and the other around L_2. Since these connections are asymptotic orbits, no manoeuvre is needed to perform the transfer from one libration point orbit to the other. A knowledge of these orbits can be very useful in the design of missions such as the Genesis Discovery Mission, and may provide the backbone for other interesting orbits in the future.
Prevention of Amblyopia and the Concept of Cure (1997)

Amblyopia is used as a comprehensive term for unexplained reduction of visual acuity, usually unilateral. As long as the visual deficit is monocular the visual loss is more of a potential problem than an actual handicap. Amblyopia is one of the most common causes of visual deficit in childhood, and since it is treatable, at least in children, considerable efforts have been made to detect it as early in life as possible. Screening programmes for amblyopia among preschool and school children have been widely organized throughout the world, although questions remain about their utility. This study evaluated amblyopia screening, focussing on some essential points that need thorough consideration before a screening programme is started. We also try to demonstrate some of the pros and cons of a screening system.
Objective assessment of compliance with treatments in acne (2005)

The study demonstrates that a range of disease-related and social factors may influence compliance with treatment in acne. The inverse relationship between DLQI and Med Ad probably reflects the profound interaction of physical and psychological factors as well as perceived treatment failure.
Efficacy of Nonfetal Human RPE for Photoreceptor Rescue: A Study in Dystrophic RCS Rats (1997)

This study determines the efficacy of nonfetal human retinal pigment epithelium (RPE) for photoreceptor rescue utilizing the dystrophic RCS rat as an animal model. Eyes from 10- and 49-year-old donors were obtained through the Rochester Eye and Human Parts Bank. The RPE was isolated by enzymatic treatment of the choroid-RPE with 2% dispase for 30 min at 37 degrees C. Mechanically dissociated RPE cells were injected at the superior hemisphere into the subretinal space of dystrophic RCS rats during the fourth postnatal week. Rats receiving vehicle injection served as sham controls. The animals were immunosuppressed with daily cyclosporine injections (10 mg/kg) and sacrificed 30 days posttransplantation for histologic evaluation of the RPE graft and its effect on photoreceptor survival. Transplantation of adult human RPE promoted the survival of photoreceptors in the dystrophic RCS rat. Morphometric analysis of the grafted superior hemisphere demonstrated a threefold increase in photoreceptor cell density (149.2 +/- 50 SD) compared to sham controls (39.7 +/- 31 SD) and the untouched inferior hemisphere (52.8 +/- 28 SD). RPE from the 49-year-old donor was as effective as RPE from the 10-year-old donor in promoting photoreceptor survival. The results of this study in RCS rats suggests that RPE from adult human donors of varied ages is suitable for transplantation and retains the capability to promote survival of photoreceptor cells. This finding opens the possibility of using nonfetal RPE cells in human retinal transplantation.
Asserting and checking determinism for multithreaded programs (2009)

The trend towards processors with more and more parallel cores is increasing the need for software that can take advantage of parallelism. The most widespread method for writing parallel software is to use explicit threads. Writing correct multithreaded programs, however, has proven to be quite challenging in practice. The key difficulty is non-determinism. The threads of a parallel application may be interleaved non-deterministically during execution. In a buggy program, non-deterministic scheduling will lead to non-deterministic results - some interleavings will produce the correct result while others will not.
Sequences involved in growth-phase-dependent expression and glucose repression of a Streptomyces  -amylase gene (1994)

In glycerol-grown, but not in glucose-grown cultures, expression in Streptomyces lividans TK24 of the cloned alpha-amylase gene (aml) of Streptomyces limosus is switched on toward the end of exponential growth. During this period, aml expression is further inducible by maltotriose. We showed that a 378 bp fragment, extending from position -204 through to +174 (relative to the transcriptional start site), included cis-acting sequences involved in aml regulation. When this fragment was present on a multicopy plasmid, the growth-phase-dependent aml expression conferred by a DNA fragment cloned on a compatible low-copy-number plasmid was greatly enhanced, as if negative regulators were being titrated. A study of the regulation of aml expression in variants with deletions in the aml promoter region indicated that a direct repeat (DR) between positions -124 and -106 (relative to the transcriptional start site) and an inverted repeat (IR) between positions +9 and +24 were good candidates for secondary and primary operator sites, respectively. Deletion of a 29 bp fragment containing the IR rendered aml expression partly growth-phase-independent, resistant to glucose repression, and insensitive to maltotriose induction.
Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study (2018)

We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants (<i>N</i> = 3,128) who also participated in the community health screening in 2010. We grouped participants' response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22-3.23; RRR = 1.36, 95% CI = 1.33-1.39; RRR = 1.36, 95% CI = 1.23-1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91-2.70; RRR = 1.59, 95% CI = 1.51-1.68; RRR = 1.40, 95% CI = 1.28-1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23-2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults' physical aspect of frailty.
Negative Pressure Wound Therapy Literature Review of Efficacy, Cost Effectiveness, and Impact on Patients' Quality of Life in Chronic Wound Management and Its Implementation in the United Kingdom (2012)

This is a paper reviewing the National Health Service (NHS) agenda in relation to the use of Negative Pressure Wound Therapy (NPWT) in chronic wound management and assesses the evidence behind it, its cost effectiveness and the outcome it has on patients' satisfaction and life style. Multiple studies over the last 10 years looking at clinical efficacy of NPWT with its cost effectiveness and the implementation of this service in the UK were reviewed. NPWT has showed a reasonable body of evidence to support its usage in chronic wounds with potential positive outcomes on finance and patients' satisfaction. However, the NHS system shows significant variations in the availability and implementation of this useful tool, depending on care providers and resources availabilities. The paper concluded that the NPWT can be a useful source of cutting down costs of chronic wound managements and saving money by its effect on expediting wound healing, which can address a part of the financial crises facing the NHS, however, has to be considered according to specific case needs. There should also be a national standard for the availability and indication of this tool to assure equal opportunities for different patients in different areas in the country.