gebhart/patrepeval huggingface dataset:
Efectos del ejercicio funcional en la condición física del adulto mayor institucionalizado (2019)

espanolObjetivo: Evaluar el efecto del ejercicio funcional sobre la condicion fisica del adulto mayor institucionalizado. Material y Metodos: Estudio experimental comparativo y correlacional a simple ciego. Se estudio a 33 sujetos de la ciudad de Talca, edad promedio 74 anos (DE= +/-7). El grupo experimental realizo ejercicios funcionales durante 12 semanas y el grupo control continuo con su rutina habitual. Fueron realizadas evaluaciones antropometricas, fisiologicas, funcionales y de autopercepcion. El estudio fue aprobado por el comite de etica de la Universidad Catolica del Maule. Fue utilizado Shapiro–Wilk para el analisis de normalidad de los datos, comparaciones antropometricas y fisiologicas mediante prueba t para muestras independientes, comparaciones de la variacion en la condicion fisica por medio de ANOVA, correlaciones a traves de Pearson y descripcion de autopercepcion mediante tabla de frecuencia. En todos los casos se adopto un p EnglishABSTRACT Objective: To evaluate the effect of functional exercise on the physical condition of the institutionalized older adult. Material and Methods: Comparative and correlational single blind study. We studied 33 subjects from the city of Talca, average age 74 years (SD = +/- 7). The experimental group performed functional exercises for 12 weeks and the control group continued with their usual routine. Anthropometric, physiological, functional and self-perception evaluations were carried out. The study was approved by the ethics committee of the Catholic University of Maule. Shapiro-Wilk was used for the normality analysis of the data, anthropometric and physiological comparisons by means of t-test for independent samples, comparisons of the variation in the physical condition by means of ANOVA, correlations through Pearson and description of self-perception by means of table frequency. In all cases, a p
CD4<sup>+</sup>CD25<sup>+</sup> REGULATORY T CELLS IN HEALTH AND DISEASE (2006)

1. Over the past 5 years, tremendous progress has been made in understanding the suppressive mechanisms of T regulatory (Treg) cells. The Treg cells, a subpopulation of T cells, have been shown to play an important role in maintaining peripheral tolerance and the prevention of autoimmunity. 2. Various populations of Treg cells have been described, including thymically derived CD4(+)CD25(+) Treg cells. These naturally occurring Treg cells are present in the periphery and are capable of suppressing proliferation and effector T cell responses both in vitro and in vivo. 3. In addition, a second subset of Treg cells, type 1 T regulatoary (Tr1) and Th3 cells, exert their suppressive capacity via cytokines such as interleukin-10 and transforming growth factor-beta and are contact independent. 4. The present review summarizes the characteristics and molecular basis of CD4(+)CD25(+) Treg cells, as well as their therapeutic potential in modulating inflammatory diseases, such as inflammatory bowel disease and rheumatoid arthritis.
Role of entrance slit in the X-ray section topography of single crystals (1980)

An investigation is made of the effect of the spectral-line width as well as of the dimension and position of the entrance slit on the diffraction image of a perfect crystal in the Lang experiment and in an experimental scheme with polychromatic focusing. Experimental results are given of the observation of the geometric image of the narrow slit as well as the changes of the fine structure of the diffraction pattern while changing the slit width and deviating the crystal from the exact Bragg condition. A theoretical analysis of the results observed is given in the approximation of geometric optics. [Russian Text Ignored.]
<i>In Situ</i>GABAergic Modulation of Synchronous Gonadotropin Releasing Hormone-1 Neuronal Activity (2002)

Evidence indicates that gonadotropin releasing hormone-1 [GnRH-1, also known as luteinizing hormone releasing hormone (LHRH)] neurons can exhibit synchronized neuroendocrine secretory activity before entrance into the CNS. In this study, we used calcium imaging to evaluate patterns of activity in individual, embryonic, GnRH-1 neurons as well as population dynamics of GnRH-1 neurons in mouse nasal explants maintained for 1 versus 3 weeks. Independent of age, GnRH-1 neurons displayed significant calcium peaks that synchronized at an interval of approximately 20 min across multiple GnRH-1 cells within an explant. Acute tetrodotoxin treatment decreased the amplitude of calcium peaks in individual GnRH-1 neurons and the duration but not the frequency of synchronized activity in the population of GnRH-1 neurons. Acute GABA(B) receptor antagonism increased the frequency of synchronized neuronal activity at both ages, whereas acute GABA(A) receptor antagonism decreased calcium oscillations in individual GNRH-1 cells as well as synchronization of the calcium pulses within the GnRH-1 population at the 1 week time point to background non-GNRH-1 cell levels. These results indicate that developing GnRH-1 neurons rely heavily on GABAergic signaling to initiate synchronized bouts of activity but thereafter, possess an innate capacity for synchronized activity patterns that are modulated by, but not completely dependent on GABAergic signaling.
Using sinusoidal stimuli and Fourier analyses for memory IC testing (2002)

This paper explores the utilization of sinusoidal stimuli and Fourier analyses to test static RAM integrated circuits. Two different tests are investigated, a writing test with a sinusoidal stimulus on the DATA line and a reading test with a sinusoidal stimulus on an address line. Up to now, results show that numerous types of faults and defects can be detected and even identified. Sensitivity of the method with respect to parameter variations is also investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Space transportation vehicle design evaluation using saturated designs (1993)

An important objective in the preliminary design and evaluation of space transportation vehicles is to find the best values of design variables that optimize the performance characteristic (e.g. dry weight). For a given configuration, the vehicle performance can be determined by the use of complex sizing and performance evaluation computer programs. These complex computer programs utilize iterative algorithms and they are generally too expensive and/or difficult to use directly in multidisciplinary design optimization. An alternative is to use response surface methodology (RSM) and obtain quadratic polynomial approximations to the functional relationships between performance characteristics and design variables. In RSM, these approximation models are then used to determine optimum design parameter values and for rapid sensitivity studies. Constructing a second-order model requires that 'n' design parameters be studied at least at 3 levels (values) so that the coefficients in the model can be estimated. There, 3(n) factorial experiments (point designs or observations) may be necessary. For small values of 'n' such as two or three, this design works well. However, when a large number of design parameters are under study, the number of design points required for a full-factorial design may become excessive. Fortunately, these quadratic polynomial approximations can be obtained by selecting an efficient design matrix using central composite designs (CCD) from design of experiments theory. Each unique point design from the CCD matrix is then conducted using computerized analysis tools (e.g. POST, CONSIZ, etc.). In the next step, least squares regression analysis is used to calculate the quadratic polynomial coefficients from the data. However, in some multidisciplinary applications involving a large number of design variables and several disciplines, the computerized performance synthesis programs may get too time consuming and expensive to run even with the use of efficient central composite designs. In such cases, it may be preferable to keep the number of design points to an absolute minimum and trade some model accuracy with cost. For this purpose, another class of experimental designs, called saturated D-optimal designs may be utilized for generating a matrix of vehicle designs. A design is called saturated when the number of design points is exactly equal to the number of terms in the model to be fitted. As a result, saturated designs require the absolute minimum number of design points ((n+1)(n+2)/s) to estimate the quadratic polynomial model coefficients. Saturated designs can be generated using the D-optimality criterion. A good saturated design should give rise to least squares estimates with minimum generalized variance.
MRXCAT: Realistic numerical phantoms for cardiovascular magnetic resonance (2014)

The proposed MRXCAT phantom framework enables versatile and realistic simulations of CMR including breathhold and free-breathing acquisitions.
OSNR-Enhancing Pure-Silica-Core Fiber with Large Effective Area and Low Attenuation (2010)

Pure-silica-core fiber with large Aeff of 134m2 is designed to enhance OSNR considering splice loss to SSMF, and realized by appropriate depressed cladding profile and soft primary coating. It also exhibits low attenuation of 0.169dB/km.
Characterization of N,N’-bis(3-Picolyl)-4-Methoxy-Isophtalamide (Picotamide) as a Dual Thromboxane Synthase Inhibitor/Thromboxane A2 Receptor Antagonist in Human Platelets (1989)

Picotamide (G137 or N,N'-bis[3-picolyl]-4-methoxy-isophtalamide), a drug which has shown platelet inhibitory effects in vitro and ex vivo, was investigated for its mechanism of action on human platelets in vitro. This compound suppresses the aggregation of human platelets induced by arachidonic acid (IC50: 1.8 x 10(-5) M), low-dose collagen (IC50: 3.5 x 10(-4) M), U46619 (IC50: 1 1.4 x 10(-4) M) and by authentic TxA2 (IC50: 1 x 10(-4) M), without affecting the aggregation induced by A23187 or primary aggregation by ADP. Picotamide inhibits dose-dependently TxA2 synthesis by platelets (IC50: 1.5 x 10(-4) M) and enhances the formation of PGE2. Picotamide-treated platelets also favour the formation of PGI2 by aspirinated endothelial cells; in addition, the drug appears to exert a direct stimulatory effect on PGI2-synthesis, at least at high concentrations. Finally, in platelet-rich plasma stimulated with arachidonic acid, picotamide increases intraplatelet cAMP while no effects on cAMP are detected in unstimulated platelets. In conclusion, picotamide is a dual thromboxane-synthase inhibitor/thromboxane-receptor antagonist in human platelets and introduces a new class of agents potentially useful in antithrombotic therapy.
Improvement of electric and magnetic properties of patterned magnetic tunnel junctions by recovery of damaged layer using oxygen showering post-treatment process (2015)

In order to recover the patterning damage and improve the electric and magnetic properties of the patterned magnetic tunnel junctions (MTJs), the novel post-treatment process using oxygen ions has been studied. Generally, the oxygen is known as an unsuitable gas for the MTJs patterning because it causes degradation of the patterned MTJs by over-oxidation of MgO. By the way, if the damaged layer could be oxidized selectively without over-oxidation of the damage-less area, oxygen can be the most effective gas to recover the patterning damage of the MTJs. In this study, for the selective oxidation, we proposed the non-reactive oxygen treatment scheme called the oxygen showering post-treatment process (OSP) using an ozone diffusion chamber. By the specific OSP conditions, 8 l/min of the flow rate, 250 °C of the temperature, and 30 s of the time, the magneto-resistance (MR) was increased from 103% to 110%, and the switching current was decreased from 41.1 μA to 31.6 μA when compared with reference data at the same resistance level. These results show that the electric and magnetic properties of the patterned MTJs by the OSP treatment have been improved compared to the reference sample. The improvement in electric and magnetic properties by the OSP treatment is assumed because the reference sample already contains slight patterning damages at the edge of the MTJs despite the optimized patterning process, and these damages have been oxidized by the OSP treatment. Moreover, by the OSP treatment, the proportion of the electric short fail was dramatically decreased from 1.51% to 0%, which is a remarkable improvement in terms of a successful commercialization of spintronic devices.
Future Technologies of the Oil Field (2011)

Technical Leaders Interview - A discussion of future technologies of the oil field. If all technological innovations produced by the oil and gas industry were added up, they would probably rival NASA’s space program or the Industrial Revolution. Driving these innovations have been the increasing challenges of locating, accessing, and exploiting hydrocarbon reserves. As oil and gas gets harder to find and extract, the costs of extraction escalate, and this drives innovation that makes the process more efficient and cost-effective. Before we speculate on the technological future of the oil field, let us look at some fundamental questions, such as what drives innovation, what does it cost, who pays for it, and who performs it? What Drives Innovation? In general, innovation relates to the application of new ideas, products, or techniques. In oil fields, it pertains to anything that extends our ability to access resources that are harder to reach, or to do so more efficiently, effectively, cleanly, and safely. We would not be talking about technology and innovation if we could take a bucket to a bubbling stream or a pond of crude and gather at will. Recent oil and gas finds and major developments have been a result of pushing the limits of existing technologies. The oil and gas industry has responded with innovative solutions to meet its business needs, bringing together exploration and production (E&P) operators, service companies, and academia (Table 1).
Forest canopy closure from classification and spectral mixing of scene components: multi-sensor evaluation of application to an open canopy (2002)

Three types of remote sensing data, colour infrared aerial photograph (CIR), compact airborne spectrographic imager (CASI) images and airborne visible/infrared imaging spectrometer (AVIRIS) image, have been used in estimating forest canopy closure for an open-canopy forest environment. The high spatial resolution CIR and CASI images were classified to generate forest canopy closure estimates. These estimates were used to validate the forest canopy closure estimation accuracies obtained using the AVIRIS image. Reflectance spectra extracted from the spectral-mode CASI image were used to atmospherically calibrate the raw AVIRIS image and converted it into a reflectance image. Classification and spectral unmixing methods have been applied to the AVIRIS image. Results indicate that both the classification and the spectral unmixing methods can produce reasonably accurate estimates of forest canopy closure (within 3% agreement) when relatively pure reflectance spectra and related statistics are extracted from the image. However, it is more challenging to use the spectral unmixing technique to derive subpixel-scale scene components whose reflectance spectra cannot be directly extracted from the AVIRIS image.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Illawarra's First White Settlers 1796 : Was Thomas Henry Huxley in the Illawarra? (1989)

According to Bill Bayley in his Blue Haven (p.22) "the eminent scientist professor [Huxley -the popularizer of Darwin's Origin of Species) visited the place [Woodstock Mill near Jamberoo] and married Heathorne's daughter Henrietta in 1847."This would appear to be untrue.After years of research I've been unable to uncover the slighest piece of evidence to substantiate Mr. Bayley's argument.Huxley married Henrietta Heathorne after whirling her around the dance-floor at one of Sydney's more elite social occasions.Bayley's suggestion that Huxley was in the lllawarra probably stems from a number of things -wishful thinking, sexism and a fondness for the 'great man' school of historiography.Henrietta Heathorne, however, was a most interesting woman
“Reports of an Addiction:” Therapeutic Intervention with a Young Adult with Cannabis Dependence (1969)

Abstract: Background and Goals: Cannabis is the most widely illicit substance around the world. Treatment success is predicted by different factors, among which, motivation for changing the behavior is one of these factors. Therefore, identifying the client’s readiness to change is important. Working with clients that are in precontemplation stage of change constitutes a big challenge for therapists. Methods: In this paper, we present the case study of João, a young adult with cannabis use disorder, comorbid with social anxiety. The therapeutic intervention followed the principles of motivational interviewing, highly recommended with clients less ready to change. It also combined techniques from cognitive-behavioral therapy and narrative therapy, to help separate the client from the problem, thus helping him to construct a more fulfilling life. Throughout the article, the subjective viewpoints of the client will be highlighted, in the form of micronarratives written by the client, suggested as therapeutic tasks. Discussion/Results: Several challenges were faced while addressing resistance and ambivalence, early on and throughout treatment. João dropout in the 23rd session, after achieving some therapeutic gains. Changes in his self-talk, documented in the micronarratives, served as indicators that his relationship with cannabis started to change. The therapeutic tasks suggested were important in helping him to increase motivation for change and to write new paths for his life. Conclusion: It is crucial to adjust the therapeutic interventions to the client’s readiness to change, and continuously reflecting about the therapeutic process, addressing moments of disengagement, early on, to increase the probability of behavior change.
Femtosecond laser system integration and application development (2008)

Femtosecond laser technology continues to evolve and mature. Today, one can find production quality lasers operating with repetition rates in the 10’s of kHz producing several Watts of power with beam quality suitable for precision micromachining applications. We will review the integration of one such laser into a production-worthy micromachining platform and discuss processing results obtained in emerging applications. This paper will highlight the migration of femtosecond lasers from laboratory tools towards production and practical applications.
A Novel Combretastatin A‐4 Derivative, AC‐7700, Shows Marked Antitumor Activity against Advanced Solid Tumors and Orthotopically Transplanted Tumors (1999)

AC-7700, a novel combretastatin A-4 derivative, suppresses the growth of solid tumors by inhibiting tumor perfusion. We evaluated the antitumor activity of AC-7700 on solid tumors in two experimental models, an advanced tumor model (murine colon 26 (c26) adenocarcinoma, colon 38 (c38) adenocarcinoma, MethA fibrosarcoma, Sarcoma 180 (S180), Lewis lung carcinoma (3LL), human LS180 adenocarcinoma) and an orthotopically transplanted tumor model (c26), compared with that of cisplatin (CDDP). The maximum tolerable dose (MTD) of CDDP suppressed early-stage c26 and c38 tumor growth when treatment was started after the tumor volume (TV) reached 0.2-0.5 cm3, but it showed reduced activity against the same tumors at an advanced growth stage when TV exceeded 2 cm3. At its MTD, AC-7700 was active against all tumors tested except 3LL in both early and advanced growth stages, reducing the tumor mass and having a curative effect in advanced c38 tumors. AC-7700 was also effective on orthotopically transplanted c26 tumors, showing a comparable activity to that on subcutaneous tumors. Unlike flavon acetic acid, which damages tumor vasculature by inducing endogenous tumor necrosis factor-alpha production, AC-7700 potently suppressed the growth of advanced c26 tumors in athymic as well as euthymic mice. These results suggest that AC-7700 is a novel antivascular agent that may have potent activity against advanced-stage cancer in the clinical setting.
Sustained release of an antitumoral drug from alginate‐chitosan hydrogel beads and its potential use as colonic drug delivery (2012)

Abstract Few researches are directed at drug delivery systems for β‐lapachone (β‐lap), a powerful anticancer agent but with limited pharmaceutical use. To overcome its limitations, we investigated controlled delivery systems of β‐lap in simulated gastric fluids in vitro from chitosan (CS) and alginate (AL) hydrogel beads with purpose for oral administration. The AL‐CS hydrogel beads were formed by coacervation and were characterized by morphology, swelling ratio, and their physicochemical properties. The hydrogel beads, with sizes of roughly 1 mm, presented good stability, and low porosity. The in vitro drug release profile was in good agreement with kinetics profiles and the Fickian model indicating diffusion as the release mechanism, with low burst effect, especially in an acid medium and allowing a prolonged release of ∼ 72 h (pH 1.2; k 2 = 0.19 ± 0.04) and (pH 7.4; k 2 = 0.20 ± 0.01). The beads were resistant to the acid medium and may be an alternative for β‐lap therapy of colorectal cancer. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
One-electron-reduction potentials of pyrimidine bases, nucleosides, and nucleotides in aqueous solution. Consequences for DNA redox chemistry (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOne-electron-reduction potentials of pyrimidine bases, nucleosides, and nucleotides in aqueous solution. Consequences for DNA redox chemistryS. Steenken, J. P. Telo, H. M. Novais, and L. P. CandeiasCite this: J. Am. Chem. Soc. 1992, 114, 12, 4701–4709Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ja00038a037https://doi.org/10.1021/ja00038a037research-articleACS PublicationsRequest reuse permissionsArticle Views1327Altmetric-Citations240LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts