gebhart/patrepeval huggingface dataset:
A mouse model of Alagille syndrome:<i>Notch2</i>as a genetic modifier of<i>Jag1</i>haploinsufficiency (2002)

Alagille syndrome is a human autosomal dominant developmental disorder characterized by liver, heart, eye, skeletal, craniofacial and kidney abnormalities. Alagille syndrome is caused by mutations in the Jagged 1 (JAG1) gene, which encodes a ligand for Notch family receptors. The majority of JAG1 mutations seen in Alagille syndrome patients are null alleles, suggesting JAG1 haploinsufficiency as a primary cause of this disorder. Mice homozygous for a Jag1 null mutation die during embryogenesis and Jag1/+ heterozygous mice exhibit eye defects but do not exhibit other phenotypes characteristic of Alagille syndrome patients ( Xue, Y., Gao, X., Lindsell, C. E., Norton, C. R., Chang, B., Hicks, C., Gendron-Maguire, M., Rand, E. B., Weinmaster, G. and Gridley, T. (1999) HUM: Mol. Genet. 8, 723-730). Here we report that mice doubly heterozygous for the Jag1 null allele and a Notch2 hypomorphic allele exhibit developmental abnormalities characteristic of Alagille syndrome. Double heterozygous mice exhibit jaundice, growth retardation, impaired differentiation of intrahepatic bile ducts and defects in heart, eye and kidney development. The defects in bile duct epithelial cell differentiation and morphogenesis in the double heterozygous mice are similar to defects in epithelial morphogenesis of Notch pathway mutants in Drosophila, suggesting that a role for the Notch signaling pathway in regulating epithelial morphogenesis has been conserved between insects and mammals. This work also demonstrates that the Notch2 and Jag1 mutations interact to create a more representative mouse model of Alagille syndrome and provides a possible explanation of the variable phenotypic expression observed in Alagille syndrome patients.
Evaluación e impacto de la educación superior en Brasil: historia, desafíos y perspectivas (2018)

The paper presents a brief analysis of the Brazilian experiences of institutional evaluation of higher education, characterizes the current policy implemented in the universities, indicating links or contrasts with previous experiences and makes a critical assessment of the implementation of this policy. From a theoretical and documentary perspective, it characterizes the evaluation models outlined or implemented throughout the eighties and nineties of the last century and analyzes the theoretical, legal and technical-operational bases of the model in force. Finally, it analyzes the current model in relation to its theoretical and methodological foundations, autonomy and external regulation, participation of the academic community, student participation in the evaluation and impact of higher education on alumni.
Memory estimation for high level synthesis (1994)

Article Memory estimation for high level synthesis Share on Authors: Ingrid M. Verbauwhede EECS Department, University of California at Berkeley, Cory Hall, Berkeley, CA EECS Department, University of California at Berkeley, Cory Hall, Berkeley, CAView Profile , Chris J. Scheers Zycad Corporation, Fremont, CA Zycad Corporation, Fremont, CAView Profile , Jan M. Rabaey EECS Department, University of California at Berkeley, Cory Hall, Berkeley, CA EECS Department, University of California at Berkeley, Cory Hall, Berkeley, CAView Profile Authors Info & Claims DAC '94: Proceedings of the 31st annual Design Automation ConferenceJune 1994 Pages 143–148https://doi.org/10.1145/196244.196313Online:06 June 1994Publication History 55citation265DownloadsMetricsTotal Citations55Total Downloads265Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
The Centromere: Chromatin Foundation for the Kinetochore Machinery (2014)

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have come to be defined as chromatin structures that establish the assembly site for the complex kinetochore machinery. In most organisms, centromere activity is defined epigenetically, rather than by specific DNA sequences. In this review, we describe selected classic work and recent progress in studies of centromeric chromatin with a focus on vertebrates. We consider possible roles for repetitive DNA sequences found at most centromeres, chromatin factors and modifications that assemble and activate CENP-A chromatin for kinetochore assembly, plus the use of artificial chromosomes and kinetochores to study centromere function.
Serum creatinine and albumin predict sarcoma‐specific survival in patients with myofibroblastic and fibroblastic sarcomas (2017)

Recent evidence suggests that common prognostic factors predicting disease progression and survival in soft tissue sarcomas (STS) are not applicable to all STS entities, indicating the need for histotype specific evaluation of new prognosticators. This study aimed at evaluating preoperative serum creatinine, albumin, and the albumin-creatinine ratio (ACR) as markers for survival in patients with malignant fibroblastic and myofibroblastic sarcomas. One hundred and thirty-two patients who underwent sarcoma resection have been included. Statistical analysis comprised uni- and multivariable Cox proportional hazard models, competing risk analysis and Kaplan-Meier estimates. The 5-year overall survival (OS) was estimated at 64.1% (95%CI: 53.7-72.8) and the 5-year sarcoma-specific mortality was 19.9% (95%CI: 12.8-28.1). Elevated serum creatinine levels were significantly associated with an impaired sarcoma-specific survival (SSS) adjusted for tumor stage (subdistribution hazard ratio (SHR) per 1 mg/dl increase: 3.27; 95%CI: 1.87-5.73; p < 0.0001). Low serum albumin levels were associated with a shorter recurrence-free survival (RFS) experience (HR per 10 g/L increase: 0.62; 95%CI: 0.41-0.94; p = 0.024). The ACR emerged as an AJCC-stage-independent prognosticator of SSS (SHR per 1 unit increase: 0.94; 95%CI: 0.90-0.98; p = 0.003). In conclusion, serum albumin and creatinine have been confirmed as predictive biomarkers for disease-specific outcomes in myofibroblastic and fibroblastic sarcomas. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2815-2824, 2017.
The Significance and Challenges of Monocyte Impairment: For the Ill Patient and the Surgeon (2016)

Impairment of monocyte function continues to be predictive of nosocomial infection, multi-organ failure, and death in some surgical patients. However, the optimal marker that could identify a patient as high risk early enough, and whether it might guide potential therapy, still is yet to be proven.
Synthesis of Embelin, Rapanone and Related Quinones by Peroxide Alkylation<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Embelin, Rapanone and Related Quinones by Peroxide Alkylation1Louis F. Fieser and Earl M. ChamberlinCite this: J. Am. Chem. Soc. 1948, 70, 1, 71–75Publication Date (Print):January 1, 1948Publication History Published online1 May 2002Published inissue 1 January 1948https://pubs.acs.org/doi/10.1021/ja01181a022https://doi.org/10.1021/ja01181a022research-articleACS PublicationsRequest reuse permissionsArticle Views396Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microbial analysis of a composted product of marine animal resources and isolation of bacteria antagonistic to a plant pathogen from the compost (2008)

A composting product of marine animal resources has been used as a fertilizer and a soil conditioner in Japan. This compost was produced by a repeated fed-batch fermentation system with three successive aerobic bioreactors. Composting temperature reached about 75 degrees C without heating. The bacterial diversity in this compost was investigated by denaturing gradient gel electrophoresis (DGGE) and sequence determination of the V3 region in the 16S rRNA genes. The sequence analysis showed that a majority of retrieved sequences corresponded to those of Bacillaceae, and we frequently found sequences similar to the 16S rDNA sequences of Bacillus thermocloacae and Bacillus thermoamylovorans. In addition, a bacterium antagonistic to a Fusarium strain was isolated from the compost. The isolate (Bacillus sp. NP-1) produced an antifungal compound, iturin A. These results suggest that this compost serves as a valuable source of plant growth-promoting rhizobacteria including the antifungal bacteria.
Exopolysaccharide production by<i>Vibrio fischeri,</i>a fouling marine bacterium (1991)

Three cultures were isolated from the microfouling material developed on stainless steel panels immersed in seawater. Cultures were tentatively identified as Vibrio fischeri strains and were assessed for extracellular polysaccharide (EPS) production. One culture was used to study the production, isolation and chemical characterization of EPS. The EPS was produced during all phases of growth and with all the substrates tested, although higher yields were obtained when glucose was used as a sole carbon and energy source. The EPS is a heteropolysaccharide containing glucose and galactose as the major (70 mol%) components and mannose, rhamnose and arabinose as minor components. The presence of hexosamine, uronic acid and pyruvate accounted for the acidic nature of EPS.
LASER ASTROMETRIC TEST OF RELATIVITY: SCIENCE, TECHNOLOGY AND MISSION DESIGN (2007)

The Laser Astrometric Test of Relativity (LATOR) experiment is designed to explore the general theory of relativity in close proximity to the Sun — the most intense gravitational environment in the solar system. Using independent time series of highly accurate measurements of the Shapiro time delay (interplanetary laser ranging accurate to 3 mm at ~2 AU) and interferometric astrometry (accurate to 0.01 picoradian), LATOR will measure gravitational deflection of light by the solar gravity with an accuracy of one part in a billion — a factor of ~30,000 better than what is currently available. LATOR will perform a series of highly accurate tests in its search for cosmological remnants of the scalar field in the solar system. We present the science, technology and mission design for the LATOR mission.
Functional Interaction of the Auxilin J Domain with the Nucleotide- and Substrate-binding Modules of Hsc70 (1997)

The uncoating of clathrin-coated vesicles requires the DnaJ homologue auxilin for targeting Hsc70 to clathrin coats. This function involves a transient interaction of the auxilin J domain with Hsc70. We have now identified the structural elements of Hsc70 that are responsible for the uncoating activity, and we show that the hitherto accepted view, which implicates the 10-kDa carboxyl-terminal variable domain of Hsc70, is incorrect. A 60-kDa chymotryptic or analogous recombinant fragment of Hsc70, which contains the ATPase- and substrate-binding domains, is sufficient to liberate clathrin from coated vesicles. Consistent with this was the observation that Hsp70 uncoats coated vesicles with the same efficacy as Hsc70 and that DnaK possesses vestigial uncoating activity. Direct binding studies demonstrated that the auxilin J domain undergoes an ATP-dependent reaction only with fragments of Hsc70 that contain both the ATPase- and substrate-binding domains. The individual domains by themselves did not bind to the J domain nor did a recombinant protein that contained the substrate-binding domain attached to the 10-kDa variable domain.
Facile UV-healable polyethylenimine–copper (C<sub>2</sub>H<sub>5</sub>N–Cu) supramolecular polymer networks (2012)

This study focuses on the development of facile polyethylenimine–copper (C2H5N–Cu) supramolecular polymer networks which upon mechanical damage are capable of reversible UV-induced self-repairs by the reformation of Cu–N coordination bonds. The chemical changes responsible for self-healing that leads to network remodeling include the formation of C2H5N–Cu complexes which, upon UV absorption, induce charge transfer between σ(N) bonding and dx2–y2(Cu) antibonding orbitals. The primary structural component responsible for network remodeling is the C2H5N–Cu coordination complex center that, upon UV exposure, undergoes square-planar-to-tetrahedral (D4h → Td) transition. The energy difference between dx2–y2 and dxz/yz orbitals during process change decreases significantly, enabling the σ(N) → dx2–y2(Cu) charge transfer and leading to energetically favorable Cu–N geometries. Manifested by virtually no temperature changes during UV-initiated self-healing, a unique feature of this network is the high efficiency of the damage–repair cycle resulting from the reversible conversion of electromagnetic radiation to chemical energy.
EXAFS analysis of a chiral alkene polymerisation catalyst incorporated in the mesoporous silicate MCM-41 (1997)

The chiral metallocene rac-ethylenebis(1-indenyl)zirconium dichloride, when immobilised on the surface of methylalumoxane-modified mesoporous silica MCM-41, is an effective catalyst for the production of highly isotactic polypropene with a unique spherulite morphology; Zr K-edge EXAFS studies of the organometallic–inorganic composite reveal not only an intact indenyl ligand framework after the immobilisation, but also the presence of a short Zr–C bond and the absence of the chloride ligands.
Active frequency-multiplier design using cad (2003)

A tutorial paper on active frequency multiplier design is presented. Rough calculations for a /spl times/2 multiplier using classical theory are developed and used as a starting point for implementation with nonlinear computer-aided design (CAD) software. The power of the nonlinear CAD software for visualizing and understanding concepts important to frequency multiplier design, and also for optimization of critical design parameters is demonstrated through realistic examples. Important design considerations for higher order multipliers are discussed, including design of output termination circuitry for a /spl times/4 multiplier at 28 GHz.
Fin-Height Effect on Poly-Si/PVD-TiN Stacked-Gate FinFET Performance (2012)

We compared the electrical characteristics, including mobility and on -state current <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> , of n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -poly-Si/PVD-TiN stacked-gate FinFETs with different fin heights <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">fin</sub> . The mobility was enhanced in devices with taller fins due to increased tensile stress. However, as gate length <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Lg</i> decreases, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> for devices with tall fins becomes worse, probably due to a high parasitic resistance <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Rp</i> . Furthermore, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> variation increased with increasing <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">H</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">fin</sub> due to rough etching of the fin sidewall. Process technologies for reducing <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Rp</i> and etching technology that yields smooth precise profiles are essential to exploit the high performance of tall FinFETs.
Toward Self-Growing Soft Robots Inspired by Plant Roots and Based on Additive Manufacturing Technologies (2017)

In this article, we present a novel class of robots that are able to move by growing and building their own structure. In particular, taking inspiration by the growing abilities of plant roots, we designed and developed a plant root-like robot that creates its body through an additive manufacturing process. Each robotic root includes a tubular body, a growing head, and a sensorized tip that commands the robot behaviors. The growing head is a customized three-dimensional (3D) printer-like system that builds the tubular body of the root in the format of circular layers by fusing and depositing a thermoplastic material (i.e., polylactic acid [PLA] filament) at the tip level, thus obtaining movement by growing. A differential deposition of the material can create an asymmetry that results in curvature of the built structure, providing the possibility of root bending to follow or escape from a stimulus or to reach a desired point in space. Taking advantage of these characteristics, the robotic roots are able to move inside a medium by growing their body. In this article, we describe the design of the growing robot together with the modeling of the deposition process and the description of the implemented growing movement strategy. Experiments were performed in air and in an artificial medium to verify the functionalities and to evaluate the robot performance. The results showed that the robotic root, with a diameter of 50 mm, grows with a speed of up to 4 mm/min, overcoming medium pressure of up to 37 kPa (i.e., it is able to lift up to 6 kg) and bending with a minimum radius of 100 mm.
An expected-case sub-cubic solution to the all-pairs shortest path problem in R (2009)

It has been shown by Alon et al. that the so-called 'all-pairs shortest-path' problem can be solved in O((MV)^2.688 * log^3(V)) for graphs with V vertices, with integer distances bounded by M. We solve the more general problem for graphs in R (assuming no negative cycles), with expected-case running time O(V^2.5 * log(V)). While our result appears to violate the Omega(V^3) requirement of "Funny Matrix Multiplication" (due to Kerr), we find that it has a sub-cubic expected time solution subject to reasonable conditions on the data distribution. The expected time solution arises when certain sub-problems are uncorrelated, though we can do better/worse than the expected-case under positive/negative correlation (respectively). Whether we observe positive/negative correlation depends on the statistics of the graph in question. In practice, our algorithm is significantly faster than Floyd-Warshall, even for dense graphs.
The measured performance of a fast local IPC (2002)

Protected application decomposition is limited by the performance of the local interprocess procedure call implementation. In this paper we measure the performance of a new IPC implementation, and show that the cost of IPC can be reduced to the cost of raw memory copy plus a small overhead. Even on machines with poor context switching performance, our implementation compares favorably with bcopy() for surprisingly small payloads.
Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain (2013)

Isoflurane anesthesia for 5 h causes death of neurons and oligodendrocytes in the G120 fetal NHP brain. In the fetal brain, as the authors previously found in the neonatal NHP brain, oligodendrocytes become vulnerable when they are just achieving myelination competence. The neurotoxic potential of isoflurane increases between the third trimester (G120) and the neonatal period in the NHP brain.
Synthesis of Radial Thermoplastic Elastomers (1976)

Abstract The combination of anionic polymerization techniques and a subsequent coupling reaction created a versatile process for producing block polymers of not only controlled block length and block sequence but also with a controlled number of branches. This process has been successfully used in commercial production since 1967. Radial styrene-diene block polymers have properties significantly different from linear polymers of the same molecular weight, showing lower melt viscosities as well as lower solution viscosities. This feature is significant in adhesive applications because it allows the use of polymers of higher molecular weights with a corresponding improvement in shear resistance.
Catalytic Addition of Hydrogen Chloride to Vinyl Chloride. Studies in a Stirred Reactor (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Addition of Hydrogen Chloride to Vinyl Chloride. Studies in a Stirred ReactorR. G. Rinker and W. H. CorcoranCite this: Ind. Eng. Chem. Fundamen. 1967, 6, 3, 333–338Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/i160023a003https://doi.org/10.1021/i160023a003research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Operation of a Vibrating Wire Viscometer with a Wire Radius of 0.207 mm in a Fluid with Nominal Viscosity, at <i>T</i> = 289.1 K, of 1.581 Pa·s at Temperatures between (289.1 and 420.7) K and a Pressure of 0.1 MPa (2007)

A viscometer formed of a tungsten wire of radius about 0.2 mm has been evaluated with measurements of the viscosity of certified reference material for viscosity N350 at viscosities up to 1.581 Pa·s, at temperatures between (289.1 and 420.7) K and a pressure of 0.1 MPa. The results differed from the cited values by less than ± 10 %.