gebhart/patrepeval huggingface dataset:
A Piezoelectric Minirheometer for Measuring the Viscosity of Polymer Microsamples (2008)

This paper describes the electromechanical design, operating principles and performance of a rheometer able to characterize the rheological behavior of microsamples of viscoelastic materials, such as polymer solutions, melt, and rubbers. It was developed with a view to portability, robustness, and ease of operation for very small samples. The rheometer operates by subjecting the samples to small-amplitude sinusoidal strain rates via an inverse piezoelectric actuator and detecting the stress response of the material via a direct piezoelectric sensor. The device operates under frequency-sweep mode in a very wide range of frequencies. Required sample sizes are typically three orders of magnitude smaller than for conventional rheometers. Owing to its lack of moving parts, the rheometer has an extremely simple design and is insensitive to vibration. Measurements on pressure-sensitive adhesives and other polymeric systems are presented and validated against a standard cone-and-plate rheometer.
A Study on the Mining Algorithm of Fast Association Rules for the XML Data (2008)

It presents an efficient mining algorithm FreqtTree for discovering all frequent patterns from XML data, and then considers mining global frequent patterns from XML data in distributed environment in this paper. First of all, the XML files are transferred to DOM tree, and then it mines all the frequent patterns from the DOM tree. It's a high efficient algorithm because it adopts the right extension technology and scans the DOM tree only one time. After that, it describes the distributed association rule data mining algorithm DFreqtTree based on DOM tree. At last, this algorithm is implemented and analyzed by Java language.
Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine (2010)

Radiometal-based radiopharmaceuticals, used as imaging and therapeutic agents in nuclear medicine, consist of a radiometal that is bound to a targeting biomolecule (BM) using a bifunctional chelator (BFC). Conventional, macroscale radiolabeling methods use an excess of the BFC-BM conjugate (ligand) to achieve high radiolabeling yields. Subsequently, to achieve maximal specific activity (minimal amount of unlabeled ligand), extensive chromatographic purification is required to remove unlabeled ligand, often resulting in longer synthesis times and loss of imaging sensitivity due to radioactive decay. Here we describe a microreactor that overcomes the above issues through integration of efficient mixing and heating strategies while working with small volumes of concentrated reagents. As a model reaction, we radiolabel 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) conjugated to the peptide cyclo(Arg-Gly-Asp-DPhe-Lys) with (64)Cu(2+). We show that the microreactor (made from polydimethylsiloxane and glass) can withstand 260 mCi of activity over 720 hours and retains only minimal amounts of (64)Cu(2+) (<5%) upon repeated use. A direct comparison between the radiolabeling yields obtained using the microreactor and conventional radiolabeling methods shows that improved mixing and heat transfer in the microreactor leads to higher yields for identical reaction conditions. Most importantly, by using small volumes (~10 µL) of concentrated solutions of reagents (>50 µM), yields of over 90% can be achieved in the microreactor when using a 1:1 stoichiometry of radiometal to BFC-BM. These high yields eliminate the need for use of excess amounts of often precious BM and obviate the need for a chromatographic purification process to remove unlabeled ligand. The results reported here demonstrate the potential of microreactor technology to improve the production of patient-tailored doses of radiometal-based radiopharmaceuticals in the clinic.
Modelling a nonlinear variable-reluctance motor drive (1990)

The paper presents models for a high-power (60 kW) variable-reluctance motor (VRM) and for the GTO-based inverter that excites the motor. Model development is motivated by the accurate performance predictions required to support optimised control and excitation. One component of the motor model analytically describes the nonlinear magnetic characteristics of the motor, accounting for both spatial and magnetic nonlinearities. The magnetic model is physically motivated, and its ties to motor geometry are discussed. Fitting of the general magnetic model to the experimental VRM is based on static magnetic measurements, but the model is shown to do an excellent job of predicting dynamic behaviour up to frequencies were eddy currents have significant influence. The magnetic model used for the motor is more accurate, yet easier to implement, than the piecewise linear magnetic model typically used for reluctance motors. Electrical terminal behaviour and torque are based on the analytic magnetic model. Another model component is presented for motor resistive losses and core losses. The former is treated analytically, while the latter is treated heuristically. The accuracy of the motor model is verified experimentally, demonstrating that the model has the ability to predict the drive performance in sufficient detail to allow the development of excitation strategies for the drive. The inverter losses considered here include conduction, snubbing and switching. The inverter model complements the motor model and creates an integrated description of the drive, which may be used to evaluate candidate excitation strategies. The accuracy of the models is verified experimentally, demonstrating they have the ability to predict the drive performance in sufficient detail to allow the development of optimised excitation and control strategies for the drive.
Immunization with major outer membrane proteins in experimental salmonellosis of mice (1979)

Porin (outer membrane protein) preparations extracted from a rough (Rb2) mutant of Salmonella typhimurium proved to be good immunogens in mice and rabbits. The antibody response achieved was measured by using enzyme-linked immunosorbent assay techniques. High titers of both antiporin and antilipopolysaccharide were detected in both species. The rabbit antiserum raised against the porins and the porin preparations themselves had a highly significant protective capacity against intraperitoneal Salmonella infection of mice. Absorption of the rabbit antiporin serum with lipopolysaccharide immunosorbent did not change its protective capacity in a passive immunization experiment, suggesting that the antiporin antibody preparations were the active components.
Current consumption dynamics at instruction and program level for a VLIW DSP processor (2002)

The paper describes a new methodology for analyzing low-level current dynamics at the instruction level and the program level for a VLIW DSP processor core. An efficient methodology for software power analysis is presented, which, unlike other research supports dynamic current analysis and complex VLIW processor cores. Analysis of high bank register allocation, equivalent functional construct usage, and program-based current, power, and energy is presented. The basic principles and methods developed throughout this research are general and applicable to complex pipelined processors. The research is important for analyzing and designing secure power-efficient DSP embedded applications.
Multinuclear MAS NMR spectroscopic study of the zeolite, MCM-22 (1995)

The sodium form of the novel silica-rich zeolite MCM-22 of moderate Si/Al ratio (44) has been synthesized hydrothermally and studied by multinuclear (1H, 27Al and 29Si) magic-angle spinning (MAS) NMR spectroscopy. 27Al spectra indicate that, in the as-synthesized (CN) and calcined materials, all the aluminium atoms are in the tetrahedral framework positions. The silicon resonance at δ=– 105.1 in the calcined material is found to correspond to Q4(1Al) and tetrahedral-sites (T-sites), T2+ T6[Q4(0AI)] of the orthorhombic structure. Silanol, Q4(1Al) and cryst allographically non-equivalent Q4(0Al) lattice sites are identified and information has been gathered on the interaction between the template protons and the lattice T-sites through 1H–29Si cross-polarization dynamics experiments. Our results also indicate that in the as-synthesized material, the 29Si resonances at δ=– 104.3 and – 120.9 correspond to distant T-sites that are located away from the template molecules in the zeolite pores.
Green turtle demise greatly exaggerated (2006)

According to a marine biologist, there are 2 million green turtles alive today, and are not endangered at all. The World Conservation Union marine turtle research group, says the organization was wrong to list green turtles as endangered during a reassessment completed in 2004.
A Novel Stereocontrolled Synthesis of 3-(1′-Hydroxyethyl)-2-Azetidinone (1993)

A stereoselective synthesis of 3-(1′-hydroxyethyl)-2-azetidinone, a key synthetic intermediate of carbapenem, is described.The method is based on a strategy that involves the selective imine-aldol reaction of a chiral imine with a silyl ketene acetal in the presence of a chiral boron reagent.
Crowdsourcing and knowledge sharing (2008)

Witkeys are a thriving type of web-based knowledge sharing market in China, supporting a form of crowdsourcing. In a Witkey site, users offer a small award for a solution to a task, and other users compete to have their solution selected.
Analog Linear-Scale Ohmmeter (1975)

This paper describes a new solid state circuit for resistance measurement in the range 1-108 Ω. The advantages of this circuit include: reliability, simplicity of design and use, low cost, and the fact that resistance scale is linear. The accuracy of measurement is around ±2 percent of reading at full-scale value in the range 1-106 Ω and ±6 percent of reading at 10 MΩ and 100 Mg. This circuit is temperature-compensated and exhibits good operational stability. The constructional cost of the instrument is about $41.00.
CHIP-SIZE WAVELENGTH DETECTORS (2007)

Chip-size wavelength detectors are described that can resolve the spectrum of the incident light with high accuracy over a broad spectral range. The devices can be configured either as compact spectrometers or precise wavelength shift detectors. Applications that are anticipated to benefit from the spectrometers include reagentless optical identification of analytes in fluidic and aerosol samples. The wavelength shift detector is widely applicable as read-out instrument for optical sensors in which a stimulus (e.g., temperature, strain, PH-value, etc.) results in a wavelength shift of an optical output signal, examples include the interrogation system for Fiber Bragg Grating sensors, photonic crystal sensors, Fabry-Perot type sensors, and sensors in which an analyte influences a laser cavity and thereby its emission wavelength.
Identification of a mutation in the structural alpha-L-fucosidase gene in fucosidosis. (1988)

Fucosidosis is an autosomal recessive lysosomal storage disorder characterized by progressive neurological deterioration and mental retardation. The disease results from deficient activity of alpha-L-fucosidase (E.C.3.2.1.51), a lysosomal enzyme that hydrolyzes fucose from fucoglycoconjugates. In an attempt to identify the mutation(s) that result(s) in fucosidosis, we performed Southern blot analysis of the structural gene encoding alpha-L-fucosidase (FUCA 1) in 23 patients affected with fucosidosis. In five patients Southern blot analysis showed obliteration of an EcoRI restriction site in the open reading frame of FUCA 1 encoding mature alpha-L-fucosidase. This abnormality was not observed in 80 controls, and it may be the basic defect responsible for fucosidosis in these patients. Both patients with the severe type I form of fucosidosis and patients with the less severe type II were shown to be homozygous for this presumed mutation. In the remaining 18 patients the EcoRI site obliteration, major-gene deletions, or insertions were not detected. This suggests that at least two different mutations are involved in fucosidosis. The heterogeneity found at the DNA level was not present at the protein level, as all fucosidosis patients investigated had low fucosidase protein (less than 6% of normal) and negligible fucosidase activity in fibroblasts and lymphoblastoid cell lines.
Spectrum of disease outcomes in mice infected with YFV-17D (2015)

The host and viral factors that influence disease outcome during flavivirus infections are not fully understood. Using the live attenuated yellow fever virus (YFV) vaccine strain 17D as a model system we evaluated how viral dose, inoculation route and immunopathogenesis contributed to disease outcome in mice deficient in the type I IFN response. We found that YFV-17D infection of IFN-α/β receptor knockout mice resulted in three distinct disease outcomes: no clinical signs of disease, fatal viscerotropic disease or fatal neurotropic disease. Interestingly, viral load at disease onset did not correlate with disease outcome. However, we found increased immune infiltrates in the brain tissues of mice that developed neurotropic disease. Additionally, mice that developed viscerotropic disease, as characterized by liver and spleen pathology and/or intestinal haemorrhage, had significantly elevated levels of alanine aminotransferase, monocyte chemotactic protein and IFN-inducible protein (IP)-10 as compared with mice with no clinical signs of disease or neurotropic disease. Furthermore, mice treated with recombinant IP-10 throughout YFV-17D infection showed increased mortality and an increased percentage of mice with viscerotropic disease. Our results demonstrated that viral load did not correlate with pathogenesis, and the host immune response played a pivotal role in disease outcome and contributed to YFV-17D pathogenesis in mice.
THE PLATELET-ACTIVATING FACTOR ANTAGONIST WEB 2170 ITS BENEFICIAL EFFECT ON DOG RENAL ALLOGRAFT SURVIVAL (1993)

Platelet-activating factor is a phospholipid mediator of inflammation produced both by inflammatory cells (e.g., basophils, neutrophils, monocytes, platelets) and endothelial cells (1); its production is stimulated by several cytokine mediators, including TNF. The role of PAF in allograft rejection includes increasing endothelial permeability leading to reduced blood flow and margination of leukocytes; recruitment of cells into the allograft at the initiation of rejection; and intercellular signaling within the graft (2–4). In vivo evidence of PAF's role in rejection comes from a rabbit model, where a sustained local release of PAF was observed during hyperacute renal allograft rejection, with associated platelet and neutrophil accumulation within 5 min of revascularization (5).
H[sub 2]O[sub 2] Decomposition Reaction as Selecting Tool for Catalysts in Li–O[sub 2] Cells (2010)

The decomposition reaction of aqueous solutions catalyzed by transition metal oxide powders has been compared with the charging voltage of nonaqueous cells containing the same catalyst. An inverse linear relationship between Ln k (rate constant for the decomposition) and the charging voltage has been found, despite differences in media and possible mechanistic differences. The results suggest that the decomposition may be a reliable, useful, and fast screening tool for materials that promote the charging process of the battery and may ultimately give insight into the charging mechanism.
Publicly Verifiable Delegation of Large Polynomials and Matrix Computations, with Applications. (2012)

Outsourced computations (where a client requests a server to perform some computation on its behalf) are becoming increasingly important due to the rise of Cloud Computing and the proliferation of mobile devices. Since cloud providers may not be trusted, a crucial problem is the verification of the integrity and correctness of such computation, possibly in a public way, i.e., the result of a computation can be verified by any third party, and requires no secret key – akin to a digital signature on a message. We present new protocols for publicly verifiable secure outsourcing of Evaluation of High Degree Polynomials and Matrix Multiplication. Compared to previously proposed solutions, ours improve in efficiency and offer security in a stronger model. The paper also discusses several practical applications of our protocols.
Downregulation of Matrix Metalloproteinase-9 and Attenuation of Edema via Inhibition of ERK Mitogen Activated Protein Kinase in Traumatic Brain Injury (2002)

Emerging data suggest that matrix metalloproteinase-9 (MMP-9) plays a critical role in the pathophysiology of brain injury. However, the regulatory mechanisms involved in vivo remain unclear. In this study, we focus on a mitogen activated protein kinase (MAPK) pathway that may trigger MMP-9 after traumatic brain injury. We aim to show that inhibition of the extracellular signal regulated kinase (ERK) would attenuate MMP-9 levels, reduce blood-brain barrier damage, and attenuate edema after trauma induced by controlled cortical impact in mouse brain. Western blots showed that phospho-ERK was rapidly upregulated after trauma. Treatment with U0126, which inhibits MEK, the kinase upstream of ERK, effectively prevented the activation of ERK. After trauma, gelatin zymography showed an increase in MMP-9. U0126 significantly reduced trauma-induced MMP-9 levels. Correspondingly, U0126 ameliorated the degradation of the tight junction protein ZO-1, which is an MMP-9 substrate, and significantly attenuated tissue edema. At 7 days after trauma, traumatic lesion volumes were significantly reduced by U0126 compared with saline-treated controls. These data indicate that the ERK MAPK pathway triggers the upregulation in MMP-9 after trauma, and further suggest that targeting the upstream signaling mechanisms that regulate deleterious MMP-9 activity may reveal new therapeutic opportunities for traumatic brain injury.
Exchange of Parts between Molecules at Equilibrium. V. Alkyl-Terminated Chain Polysulfides and Polyselenides (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExchange of Parts between Molecules at Equilibrium. V. Alkyl-Terminated Chain Polysulfides and PolyselenidesDavid. Grant and John R. Van WazerCite this: J. Am. Chem. Soc. 1964, 86, 15, 3012–3017Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://pubs.acs.org/doi/10.1021/ja01069a010https://doi.org/10.1021/ja01069a010research-articleACS PublicationsRequest reuse permissionsArticle Views262Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular modeling of triazine type MDR modulators using CoMFA and CoMSIA approaches (2002)

In the present study a series of 30 triazine derivatives was investigated by 3D QSAR methods with respect to their MDR reversing activity in vitro. Two approaches were applied and compared: comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). Molecular models with good predictive power were derived using steric, electrostatic and hydrophobic fields of the compounds. The results indicated the dominant role of the electrostatic and hydrophobic fields for MDR reversing activity of the investigated modulators. The obtained statistical parameters (Qcv2, Qpr2) showed that the CoMFA and CoMSIA models have similar predictivity. The CoMSIA models were slightly better than the CoMFA ones and obtained with lower number of principal components. The models were graphically interpreted using CoMFA and CoMSIA contour plots. The structural regions responsible for the differences in anti-MDR activity were analyzed in respect to their electrostatic and hydrophobic nature. An easier interpretation of the CoMSIA contour plots was noticed.
Strong affinity of hydrogen for the GaN(000-1) surface: Implications for molecular beam epitaxy and metalorganic chemical vapor deposition (2004)

The stabilities of clean and hydrogen covered GaN(000-1) surfaces are determined using density functional theory together with a finite temperature thermodynamics approach. Hydrogen has an extremely high affinity for the N-face surface: Even under ultrahigh vacuum conditions as realized in molecular beam epitaxial growth, with a residual hydrogen pressure of 10−12atm, the hydrogen terminated surface is, for very N-rich conditions, more stable than any clean surface. A transition to a surface covered by a Ga adlayer is predicted to occur as the Ga chemical potential increases. In typical metalorganic chemical vapor deposition conditions the (000-1) surface is predicted to be covered by 0.75 monolayers of hydrogen. The slower growth rate on the (000-1) surface in comparison to the (0001) surface is attributed to low adsorption of N on the H-covered (000-1) surface.
Editorial (2008)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Clinical Responses to Undiluted and Diluted Smallpox Vaccine (2002)

When given by a bifurcated needle, vaccinia virus vaccine can be diluted to a titer as low as 10(7.0) pfu per milliliter (approximately 10,000 pfu per dose) and induce local viral replication and vesicle formation in more than 97 percent of persons.
Automatic assessment of medication states of patients with Parkinson's disease using wearable sensors (2016)

Motor fluctuations are a major focus of clinical managements in patients with mid-stage and advance Parkinson's disease (PD). In this paper, we develop a new patient-specific algorithm that can classify those fluctuations during a variety of activities. We extract a set of temporal and spectral features from the ambulatory signals and then introduce a semi-supervised classification algorithm based on K-means and self-organizing tree map clustering methods. Two different types of cluster labeling are introduced: hard and fuzzy labeling. The developed algorithm is evaluated on a dataset from triaxial gyroscope sensors for 12 PD patients. The average result of using K-means and fuzzy labeling on the trunk and the more affected leg sensors' readings was 75.96%, 70.57%, and 86.93% for accuracy, sensitivity, and specificity, respectively. The accuracy for individual patients varied from 99.95% to 42.53%, which was correlated with dyskinesia severity and the improvement of the PD symptoms with medication.