gebhart/patrepeval huggingface dataset:
The Hybridization of CdSe/ZnS Quantum Dot on InGaN Light-Emitting Diodes for Color Conversion (2008)

We have demonstrated the fabrication and characterization of hybrid CdSe/ZnS quantum dot (QD)-InGaN blue LEDs. The chemically synthesized red light (lambda = 623 nm) QD solutions with different concentrations were dropped onto the blue InGaN LEDs with an emission peak of 453 nm and the turn-on voltage of 2.6 V. In this configuration, the CdSe/ZnS core/shell QDs played the role of a color-conversion center. It was clearly observed that the emission intensity from QDs was increased with increasing QD concentration. With a QD concentration of 10 mg/ml in toluene was incorporated, the ratio of emission intensity of QDs to that of InGaN quantum wells reached 0.17, whereas the Commission Internationale de lpsilaEclairage (CIE) chromaticity coordinates greatly shifted to (0.29, 0.14). From the spatial mapping of electroluminescence spectra, the decrease of the intensity of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">QW</sub> seems to be faster than that of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">QD</sub> , which suggests that the QD film thickness may be thicker in the edge of the surface of InGaN chip. There will, therefore, convert higher proportion of blue light to red light. Also, the resin-encapsulated hybrid LEDs have a divergence angle (the full angle at 1/ <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">e</i> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> intensity) of about 20 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">deg</sup> as the device is operated at 10 mA. Furthermore, under the injection current of 20 mA and room temperature, this device can be operated for more than 1000 h without any obvious degradation. From our results, it can be proven that the synthesized QDs are promising nanophosphors for color-conversion applications of solid-state LEDs. However, to more efficiently convert the blue light to red light, a denser QD solution with higher quantum yield must be utilized.
Purification, crystallization and preliminary X-ray structure analysis of the banana lectin from<i>Musa paradisiaca</i> (2004)

The banana lectin from Musa paradisiaca, MW 29.4 kDa, has been isolated, purified and crystallized. The trigonal crystals contain one dimeric molecule in the asymmetric unit. The structure has been solved using molecular replacement to a resolution of 3 A. The structure of the subunit is similar to that of jacalin-like lectins.
Estrogen receptor in malignant melanoma. (1987)

The significance of an estrogen binding protein (ER) in malignant melanoma remains controversial. We have prospectively assayed for ER on 141 patients with malignant melanoma and correlated the presence of the ER with known prognostic variables. The overall incidence of ER was 43%. The incidence of ER in males was 38.7% and 50% in females (not significant). There is an increased incidence of ER+ melanoma in women with extremity lesions (P = .08). The disease-free interval (DFI), survival, and recurrent interval were 42.0 +/- 4.0, 52.3 +/- 4.3, 13.7 +/- 1.7 months in ER- patients; 63.7 +/- 11.6, 76.1 +/- 11.4, 26.5 +/- 7.3 months in ER+ patients (1 to 10 fmol/mg cytosol protein), and 69.8 +/- 17.9, 102.7 +/- 27.9, 29.4 +/- 9.9 months in ER+ patients (greater than 10 fmol/mg cytosol); respectively. When ER+ groups were combined, the DFI in women with ER+ lesions was significantly longer than those with ER- tumors (P less than .05). Cox multivariate analysis demonstrated that ER status is a significant variable of survival along with thickness level and nodal status. These observations suggest that ER may be a marker for a more biologically indolent melanoma.
Alteration of white matter MR signal intensity in frontotemporal dementia. (1997)

Increased MR signal intensity in the frontotemporal white matter on T2- and proton density-weighted MR images is a useful diagnostic sign of frontotemporal dementia and distinguishes this condition from Alzheimer disease.
Hidden Markov Model for eye gaze prediction in networked video streaming (2011)

With the advent of eye gaze tracking technology, eye gaze is increasingly being used as a media interaction trigger in a variety of applications, such as eye typing, video content customization, and network video streaming based on region-of-interest (ROI). The reaction time of a gaze-based networked system, however, is in practice lower-bounded by the round trip time (RTT) of today's networks, which can be large. To improve the efficacy of gaze-based networked systems, in the paper we propose a Hidden Markov Model (HMM)-based gaze prediction strategy to predict future gaze locations to lower end-to-end reaction delay. We first design an HMM with three states corresponding to human's three major types of intrinsic eye movements. HMM parameters are obtained offline on a per-video basis during training phase. During testing phase, a window of noisy gaze observations are collected in real-time as input to a forward algorithm, which computes the most likely HMM state. Given the deduced HMM state, linear prediction is used to predict gaze location RTT seconds into the future. We demonstrate the applicability of our gaze prediction strategy by focusing on ROI-based bit allocation for network video streaming. To reduce transmission rate of a video stream without degrading viewer's perceived visual quality, we allocate more bits to encode the viewer's current spatial ROI, while devoting fewer bits in other spatial regions. The challenge lies in overcoming the delay between the time a viewer's ROI is detected by gaze tracking, to the time the effected video is encoded, delivered and displayed at the viewer's terminal. To this end, we use our proposed gaze-prediction strategy to predict future eye gaze locations, so that optimized bit allocation can be performed for future frames. Our experiments show that bit rate can be reduced by 21% without noticeable visual quality degradation when end-to-end network delay is as high as 200ms.
A retargetable table reader (2002)

We describe the architecture of a system for reading machine-printed documents in known predefined tabular-data layout styles. In these tables, textual data are presented in record lines made up of fixed-width fields. Tables often do not rely on line-art (ruled lines) to delimit fields, and in this way differ crucially from fixed forms. Our system performs these steps: copes with multiple tables per page; identifies records within tables; segments records into fields; and recognizes characters within fields, constrained by field-specific contextual knowledge. Obstacles to good performance on tables include small print, tight line-spacing, poor-quality text (such as photocopies), and line-art or background patterns that touch the text. Precise skew-correction and pitch-estimation, and high-performance OCR using neural nets proved crucial in overcoming these obstacles. The most significant technical advances in this work appear to be algorithms for identifying and segmenting records with known layout, and integration of these algorithms with a graphical user interface (GUI) for defining new layouts. This GUI has been ergonomically designed to make efficient and intuitive use of exemplary images, so that the skill and manual effort required to retarget the system to new table layouts are held to a minimum. The system has been applied in this way to more than 400 distinct tabular layouts. During the last three years the system has read over fifty million records with high accuracy.
A Solid-Phase System (SPACE) for the Detection and Quantification of Rotavirus in Faeces (1979)

This report describes the development of a solid-phase haemadsorption system using chromic chloride-linked, antibody coated erythrocytes. It is proposed to call this technique solid phase aggregation of coupled erythrocytes (SPACE). The system is suitable for the detection of virus antigens, such as from rotavirus infections, which are present in 'dirty' or 'mixed' preparations such as faeces, urine or exudates. The test uses microtitre U-form plates coated with specific antivirus antibody; faecal suspensions are added and virus or antigen allowed to adsorb. The plates are then washed and adsorbed antigens are detected by the addition of virus-specific IgG-coated erythrocytes. The resultant settling pattern is read in the same manner as a conventional haemagglutination test. The system is compared with electron microscopy and fluorescent antibody techniques.
Nebulizer Use and Maintenance by Cystic Fibrosis Patients: A Survey Study (2004)

This study demonstrates that CF patients and their respiratory therapists should immediately address and improve their nebulizer cleaning methods and replacement practices. There should be more focus on teaching patients to regularly clean and replace nebulizers.
A <i>Helicobacter pylori</i> Vacuolating Toxin Mutant That Fails To Oligomerize Has a Dominant Negative Phenotype (2006)

Most Helicobacter pylori strains secrete a toxin (VacA) that causes massive vacuolization of target cells and which is a major virulence factor of H. pylori. The VacA amino-terminal region is required for the induction of vacuolization. The aim of the present study was a deeper understanding of the critical role of the N-terminal regions that are protected from proteolysis when VacA interacts with artificial membranes. Using a counterselection system, we constructed an H. pylori strain, SPM 326-Delta49-57, that produces a mutant toxin with a deletion of eight amino acids in one of these protected regions. VacA Delta49-57 was correctly secreted by H. pylori but failed to oligomerize and did not have any detectable vacuolating cytotoxic activity. However, the mutant toxin was internalized normally and stained the perinuclear region of HeLa cells. Moreover, the mutant toxin exhibited a dominant negative effect, completely inhibiting the vacuolating activity of wild-type VacA. This loss of activity was correlated with the disappearance of oligomers in electron microscopy. These findings indicate that the deletion in VacA Delta49-57 disrupts the intermolecular interactions required for the oligomerization of the toxin.
The hepatitis C virus internal ribosome-entry site: a new target for antiviral research (2001)

The hepatitis C virus (HCV) is the main causative agent of non-A, non-B hepatitis in humans and a major cause of mortality and morbidity in the world. Currently there is no effective treatment available for the infection caused by this virus, whose replication depends on an unusual translation-initiation mechanism. The viral RNA contains an internal ribosome-entry site (IRES) that is recognized specifically by the small ribosomal subunit and by eukaryotic initiation factor 3, and these interactions allow cap (7-methylguanine nucleotide)-independent initiation of viral protein synthesis. In this article, we review the structure and mechanism of translation initiation of the HCV IRES, and its potential as a target for novel antivirals.
Detection of prostate cancer cells circulating in peripheral blood by reverse transcription-PCR for hKLK2. (1997)

Two of the human tissue kallikrein family, hK2 and hK3 (prostate-specific antigen), are primarily produced by the prostatic epithelium under the regulation of androgens. In this study, we detected prostate cancer cells that expressed hKLK2 or hKLK3 mRNA in the peripheral blood of patients with prostate cancer using reverse transcription-PCR (RT-PCR). We then demonstrated some differences in characteristics, such as differentiation of cancer cells and response to antiandrogen therapy, between hKLK2 and hKLK3 mRNA-expressing prostate cancer cells. Total RNA was isolated from 41 patients with known prostate cancer, 7 patients with benign prostatic hyperplasia, and 20 normal volunteers. By RT-PCR, hKLK2 mRNA was detected in 7 patients (33%), and hKLK3 mRNA was detected in 17 (81%) of 21 stage D prostate cancer patients. In contrast, all patients with benign prostatic hyperplasia and healthy volunteers were negative. From comparison of the background of the patients positive for hKLK2 and/or hKLK3 mRNA, it became evident that the response to antiandrogen therapy and the expression of hKLK2 mRNA were reciprocally correlated, in contrast with the expression of hKLK3 mRNA. Additionally, our study clearly demonstrated that the detection of hKLK2 mRNA in the peripheral blood was useful for screening patients with certain prostate cancers that did not express hK3. We conclude that taking advantage of the difference between hKLK2 mRNA and hKLK3 mRNA expression is clinically useful for following up prostate cancer patients.
Distractibility in Schizophrenia: State and Trait Aspects (1989)

This report compared the selective attention of 19 schizophrenic in-patients, 10 recently discharged schizophrenic out-patients, 21 schizophrenic out-patients in stable clinical remission, 33 first-degree relatives of schizophrenics from 15 families, 25 students who scored deviantly on questionnaire measures of magical ideation, perceptual aberrations, and physical anhedonia, and 20 normal controls. Results indicated that distractors only disrupted the performance of schizophrenic in-patients, suggesting that differential deficits in selective attention are a marker of episodes of schizophrenia. A propensity to interject phonemes from the distracting message was found not only in patients in or just emerging from a psychotic episode, but also in the remaining vulnerable but non-psychotic groups, suggesting that intrusion errors might be a mediating vulnerability marker. The findings suggest both state and possibly trait aspects to distractibility in schizophrenia.
Data Partitioning for Parallel Entity Matching (2010)

Entity matching is an important and difficult step for integrating web data. To reduce the typically high execution time for matching we investigate how we can perform entity matching in parallel on a distributed infrastructure. We propose different strategies to partition the input data and generate multiple match tasks that can be independently executed. One of our strategies supports both, blocking to reduce the search space for matching and parallel matching to improve efficiency. Special attention is given to the number and size of data partitions as they impact the overall communication overhead and memory requirements of individual match tasks. We have developed a service-based distributed infrastructure for the parallel execution of match workflows. We evaluate our approach in detail for different match strategies for matching real-world product data of different web shops. We also consider caching of in-put entities and affinity-based scheduling of match tasks.
A General Method of Gene Isolation (1973)

A general method of gene isolation has been developed that involves the chemical linkage of RNA to cellulose by a water-soluble carbodiimide, and the continuous circulation of DNA containing specific sequences complementary to the RNA. The temperature of the cellulose matrix is maintained at 37 degrees (50% formamide, 0.3 M NaCl-0.03 M Na(3) citrate) to allow efficient DNA-RNA interaction in the stationary phase, while unreacted and any reassociated DNA is denatured at 90 degrees and then recirculated into the hybridization chamber. Between 40 and 45% of fragmented (32)P-labeled simian virus (SV)40 DNA was removed from the circulating solution when cellulosebound SV40-specific RNA, assymmetrically transcribed in vitro with Escherichia coli RNA polymerase, was used. In the presence of 10(4)-fold excess of sheared E. coli DNA, nearly half of the [(32)P]SV40 DNA was recovered from the mixture as a DNA-RNA hybrid with negligible contamination by bacterial DNA. The isolation procedure is almost quantitative for the complementary DNA. The efficiency and selectivity of this method permit the isolation of a defined DNA sequence from a large and complex genome.
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro (1989)

Aerobic glycolysis, a metabolic characteristic of malignant cells, can be exploited to increase the concentration of lactic acid selectivity in tumor tissues in vivo by systemic administration of glucose (E. Jähde and M. F. Rajewsky, Cancer Res., 42: 1505-1512, 1982). To investigate whether a more acidic microenvironment can enhance the effectiveness of cytocidal drugs, we have analyzed the colony-forming capacity of M1R rat mammary carcinoma cells exposed to bis-chloroethylating agents in culture as a function of extracellular pH (pHe). At pHe 6.2 the cytotoxicity of 4-hydroperoxycyclophosphamide, as measured by inhibition of colony formation, was potentiated by a factor of approximately 200 as compared to pHe 7.4. Similar results were obtained with mafosfamide, nitrogen mustard, nornitrogen mustard, melphalan, and chlorambucil; not, however, with ifosfamide. As indicated by experiments using the ionophor nigericin for rapid equilibration of pHe and intracellular pH (pHi; measured with pH-sensitive microelectrodes), modulation of drug action by varying pHe primarily resulted from the concomitant decrease in pHi. The acidic microenvironment enhanced cytotoxicity most effectively during the phase of cellular drug uptake and monofunctional alkylation of DNA. DNA cross-link formation appeared to be less affected by pH, and lowering of pHe during the phase of cross-link removal was only marginally effective.
Generation of ultrashort electron bunches by colliding laser pulses (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. B. Schroeder, P. B. Lee, J. S. Wurtele, E. Esarey, W. P. Leemans; Generation of ultrashort electron bunches by colliding laser pulses. AIP Conf. Proc. 12 July 1999; 472 (1): 461–470. https://doi.org/10.1063/1.58911 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Modular syntheses of multidentate ligands with variable N-donors: applications to tri- and tetracopper(i) complexes (2007)

A general method for the preparation of multidentate ligands comprised of a multi-imine platform derived from 1,1,1-tris(aminomethyl)ethane or tris(aminoethyl)amine connected to bi- and tridentate N-donor chelates has been developed. The feasibility of the method has been demonstrated through the synthesis and characterization of a large set of these ligand types. Complexation to Cu(I) was accomplished for several cases, yielding tri- and tetracopper(I) complexes that have been characterized in solution by NMR spectroscopy and conductivity, and in the solid state by elemental analysis, mass spectrometry, and/or X-ray crystallography. These complexes are potentially useful for modeling multicopper protein active sites.
In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies (2018)

The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Current antivenoms are both scarce on the African continent and present a number of drawbacks as they are derived from the plasma of hyper-immunized large mammals. Here, we describe the development of an experimental recombinant antivenom by a combined toxicovenomics and phage display approach. The recombinant antivenom is based on a cocktail of fully human immunoglobulin G (IgG) monoclonal antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba whole venom in a rodent model. Our results show the potential use of fully human monoclonal IgGs against animal toxins and the first use of oligoclonal human IgG mixtures against experimental snakebite envenoming.
Roles of prostaglandin receptors in female reproduction (2014)

Prostaglandins (PGs) have long been known to play roles in various processes of female reproduction; however, the molecular mechanisms therein remained unsolved until recently. This review summarizes the recent progress towards understanding the molecular mechanisms underlying PG actions in fertilization and parturition. A series of studies using EP2-deficient mice demonstrated that after ovulation chemokine signalling in the cumulus cells stimulates integrin activation and cumulus extracellular matrix (ECM) assembly through the RhoA/ROCK/actomyosin pathway, although excessive chemokine signalling disturbs sperm penetration. PGE2-EP2 signalling suppresses such a chemokine signalling and stimulates cumulus ECM disassembly, which contributes to successful fertilization. A series of studies using FP-deficient mice revealed that PGF(2α)-FP signalling induces parturition at least by terminating progesterone production; however, some other EP signals are likely to be involved in parturition by inducing myometrial contraction. Therefore, it should be clarified as to which EP and/or FP receptor signals are physiologically essential for myometrial contraction and successful parturition.
Biodegradable Poly(D,L-lactic-co-glycolic acid)-Based\nMicro/Nanoparticles for Sustained Release of Protein Drugs - A Review (2014)

Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) and PLGA-based polymeric nanoparticles are widely used for sustained release of protein and peptide drugs. These formulations are usually prepared by water/oil/water (W/O/W) and solid/oil/water (S/O/W) double emulsion solvent evaporation method. Other methods of preparation are nanoprecipitation, emulsion solvent diffusion and salting-out. This review attempts to address the effects of PLGA molecular weight, lactide to glycolide ratio, crystallinity, hydrophilicity as well as nanoparticles preparation variables (e.g., homogenizer speed, surfactants nature and concentration) on the size, morphology, drug encapsulation efficiency and release profile of PLGA mico/nanoparticles. The current knowledge of protein instability during preparation, storage and release from PLGA micro/nanoparticles and protein stabilization approaches has also been discussed in this review.Keywords: Poly(D, L-lactic-co-glycolic acid), Nanoparticles, Microparticles, Protein/peptides, Sustained release, Protein instability
Osteoinduction by Chitosan-Complexed BMP: Morpho-Structural Responses in an Osteoporotic Model (1997)

Bone quality is the result of a complex relationship between bone mass, bone structure, and mechanical characteristics of these individual components. The mass of bone tissue is affected by nutritional factors and other causes, such as bone growth factors like bone morphogenetic proteins (BMPs). Since chitosans promote ordered regeneration of soft tissue and osteoinduction, an osteoporotic model was studied to evaluate the pattern of bone regeneration in the presence of BMP linked to chitosan. BMP was released from the chitosan matrix as a consequence of chitosan biodegradation. Our data show that the association of BMP with chitosan seemed to improve the bone tissue regeneration in a surgical bone defect. This result provides validity to biochemical approaches for therapeutical correction of afflictions in the elderly, such as osteoporosis.