gebhart/patrepeval huggingface dataset:
The variable relationship between arm and hand use: A rationale for using finger magnetometry to complement wrist accelerometry when measuring daily use of the upper extremity (2014)

Wrist-worn accelerometers are becoming more prevalent as a means to assess use of the impaired upper extremity in daily life after stroke. However, wrist accelerometry does not measure joint movements of the hand, which are integral to functional use of the upper extremity. In this study, we used a custom-built, non-obtrusive device called the manumeter to measure both arm use (via wrist accelerometry) and hand use (via finger magnetometry) of a group of unimpaired subjects while they performed twelve motor tasks at three intensities. We also gave the devices to four stroke subjects and asked them to wear them for six hours a day for one month. From the in-lab testing we found that arm use was a strong predictor of hand use for individual tasks, but that the slope of the relationship varied by up to a factor of ~12 depending on the task being performed. Consistent with this, in the daily use data collected from stroke subjects we found a broad spread in the relationship between arm and hand use. These results suggest that analyzing the spread of the relationship between daily hand and arm use will give more insight into upper extremity recovery than wrist accelerometry or finger magnetometry alone, because the spread reflects the nature of the daily tasks performed as well as the amount of upper extremity use.
A combined hierarchical placement algorithm (1993)

A hierarchical placement algorithm which combines mincut partitioning and simulated annealing has been developed. The objective of mincut partitioning is to minimize the number of crossing nets while the objective of placement by simulated annealing is usually to minimize the total estimated wire-length. The combined placement algorithm can optimize both the routing density and the estimated wire-length. For efficiency, the placement is performed using multiple levels of hierarchy in the top-down direction, i.e., big groups of cells are placed at the beginning and leafcells are placed at the final level. Several standard-cell and sea-of-gates circuits are placed using the combined placement techniques and promising results are obtained when compared with those of several other placement methods.
Interference management using basestation coordination in broadband wireless access networks (2006)

Abstract This paper proposes a transmission‐scheduling algorithm for interference management in broadband wireless access networks. The algorithm aims to minimize the cochannel interference using basestation coordination while still maintaining the other quality of service (QoS) requirements such as packet delay, throughput and packet loss. The interference reduction is achieved by avoiding (or minimizing) concurrent transmission of potential dominant interferers. Dynamic slot allocation based on traffic information in other cells/sectors is employed. In order to implement the algorithm in a distributed manner, basestations (BSs) have to exchange traffic information. Both real‐time and non‐real‐time services are considered in this work. Results show that significant reduction in the packet error rate can be achieved without increasing the packet delay at low to medium loading values and with a higher but acceptable packet delay at high loading values. Since ARQ schemes can also be used for packet error rate reduction, we compare the performance of the proposed scheme with that of ARQ. Results indicate that although ARQ is more effective in reducing packet error rate, the proposed algorithm incurs much less packet delay particularly at medium to high loading. Copyright © 2006 John Wiley & Sons, Ltd.
Hybrid Tissue Engineering Scaffolds by Combination of Three-Dimensional Printing and Cell Photoencapsulation (2015)

Three-dimensional (3D) printing offers versatile possibilities for adapting the structural parameters of tissue engineering scaffolds. However, it is also essential to develop procedures allowing efficient cell seeding independent of scaffold geometry and pore size. The aim of this study was to establish a method for seeding the scaffolds using photopolymerizable cell-laden hydrogels. The latter facilitates convenient preparation, and handling of cell suspension, while distributing the hydrogel precursor throughout the pores, before it is cross-linked with light. In addition, encapsulation of living cells within hydrogels can produce constructs with high initial cell loading and intimate cell-matrix contact, similar to that of the natural extra-cellular matrix (ECM). Three dimensional scaffolds were produced from poly(lactic) acid (PLA) by means of fused deposition modeling. A solution of methacrylamide-modified gelatin (Gel-MOD) in cell culture medium containing photoinitiator Li-TPO-L was used as a hydrogel precursor. Being an enzymatically degradable derivative of natural collagen, gelatin-based matrices are biomimetic and potentially support the process of cell-induced remodeling. Preosteoblast cells MC3T3-E1 at a density of 10 × 10<sup>6</sup> cells per 1 mL were used for testing the seeding procedure and cell proliferation studies. Obtained results indicate that produced constructs support cell survival and proliferation over extended duration of our experiment. The established two-step approach for scaffold seeding with the cells is simple, rapid, and is shown to be highly reproducible. Furthermore, it enables precise control of the initial cell density, while yielding their uniform distribution throughout the scaffold. Such hybrid tissue engineering constructs merge the advantages of rigid 3D printed constructs with the soft hydrogel matrix, potentially mimicking the process of ECM remodeling.
The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8<sup>+</sup> T cells in HIV‐1‐infected typical progressors, but not in long‐term non‐progressors (2008)

Persistent HIV infection results in a decrease in absolute counts of CD4(+) CD25(+) regulatory T cells (Treg). To investigate the role of decreased Treg counts in the regulation of excessive activation and apoptosis of CD8(+) T cells in human immunodeficiency virus (HIV)-1 infection, we characterized Treg in 83 HIV-1-infected individuals, including 19 long-term non-progressors (LTNPs) and 51 typical progressors (TPs) who were treatment-naïve, and 13 AIDS patients on highly active antiretroviral therapy (HAART), of whom nine were complete responders (CRs) and the remaining four were non-responders (NRs) to the treatment. TPs but not LTNPs had a significant decrease in absolute counts of circulating Treg, which was inversely correlated with the activation and apoptosis of CD8(+) T cells. Efficient HAART was found to increase Treg counts in CR patients and temper the excessive activation and apoptosis of CD8(+) T cells. Moreover, isolated Treg significantly inhibited the spontaneous and anti-CD3-induced apoptosis of CD8(+) T cells in a dose-dependent manner in vitro. Thus, our findings indicate that the decrease in Treg closely correlates with the increase in apoptotic CD8(+) T cells and disease progression in chronic HIV-1 infection, and that Treg may play a key role in maintaining the balance between the amount and quality of CD8(+) T cells in HIV-1 infection. Manipulation of Treg function may be a promising strategy for immune therapy of this disease.
A Luminescent Microporous Metal–Organic Framework with Highly Selective CO<sub>2</sub> Adsorption and Sensing of Nitro Explosives (2014)

A luminescent microporous metal-organic framework based on a π-electron-rich tricarboxylate ligand and an In(3+) ion has been solvothermally obtained and characterized and exhibits highly selective CO2 adsorption over CH4 and N2 gases and selective sensing of the nitro explosive 2,4,6-trinitrophenol.
DNA fingerprinting of<i>Streptococcus uberis</i>: a useful tool for epidemiology of bovine mastitis (1989)

A simple and reproducible typing system based on restriction fragment size of chromosomal DNA was developed to compare isolates of Streptococcus uberis obtained from the bovine mammary gland. The endonuclease giving the most useful restriction patterns was Hind III. Although seven other endonucleases (Bgl 1, Eco R1, Not 1, Pst 1, Sfi 1, Sma 1, Xba 1) were also tested in the system. An image analyser was used to obtain a densitometric scan and a graphic display of the restriction patterns. Such a system will allow large scale data storage for future computer-aided comparison.
Determination of iron sulphides in roofing slates from the north west of Spain (2002)

The most important production of roofing slates in the world is quarried from the Ordovician formations of the Truchas Syncline, which have the largest amount of working quarries. Roofing slates, sometimes, have crystallized iron sulphides such as pyrite, pyrrhotite and other minerals. These iron sulphides oxidise and stain the tiles when are exposed to atmospheric conditions, so much oxidized how much more inclined is the roof. Galician quarrymen distinguish between harmless pyrite (i.e., resistant cubes of pyrite) and damaging pyrite (i.e., other alterable metallic minerals such as pyrrhotite, chalcopyrite, marcasite and arsenopyirite). An improved identification method is proposed using both methods (a) chemical element ratios of samples under electron microprobes and (b) quantitative determination of the iron sulphides in the slate measuring the oxidized areas by digital camera. The analysed Fe/S ratios, in an XY plot, of seventy metallic samples, define three separated zones: pyrite, pyrrhotite and iron oxi-hydroxides. Quantitative determination of iron sulphides in the slate tile were performed by sinking the tile horizontally for six hours in oxygen peroxide (3% diluted) and capturing the oxidation areas with a magnetic camera and analysing the bitmap images with Sigma-Scan 5 software. The proposed method is faster than the Spanish UNE norm (UNE-EN- 12326-2 Sept.2000), which requires thermal strike cycles for a month. The necessary use of heavy analytical equipment such as electron microprobes can be facilitated by installing it in the Slate Technological Centre of Sobradelo de Valdeorras (Orense) or by using a simple optical stereoscopic zoom microscope to classify the iron minerals.
The Determination of the Poly(oxyethylene) Oligomer Distribution in a Non-ionic Surfactant by Means of Thin-Layer Chromatography (1989)

Abstract The analytical method for determining the distribution of the polymerization degree of the oxyethylene (OE) chain in commercially available poly(oxyethylene) alkyl ether (CmEn) was investigated by means of thin-layer chromatography with flame-ionization detection (TLC-FID). It was found that the method of calculating the relative response factors of every OE chain to FID could be determined, and the analysis of the distribution of the polymerization degree of the OE chain in commercially available CmEn became possible using the TLC-FID method.
Reduction of Cobalt and Iron Corroles and Catalyzed Reduction of CO<sub>2</sub> (2002)

The role of cobalt and iron corroles in catalytic CO2 reduction has been studied. Chemical, electrochemical, and photochemical reductions of the stable metal corroles Ph3PCoIII(tpfc) (tpfc = 5,10,15-tris(pentafluorophenyl)corrole), ClFeIV(tpfc), and ClFeIV(tdcc) (tdcc = 5,10,15-tris(2,6-dichlorophenyl)corrole) have been carried out in acetonitrile solutions. Stepwise reduction to the [MII(tpfc)]- and [MI(tpfc)]2- states was observed in all cases. Gradual reduction with sodium amalgam permitted recording of the optical absorption spectra of the various oxidation states and showed that the MI state reacts with CO2. Cyclic voltammetry in Ar-saturated acetonitrile solutions permitted determination of the following half-wave potentials: for Ph3PCoIII(tpfc), 1.11 V, 0.72 V, −0.42 V (Epc), −1.44 V, −2.3 V (Epc); for ClFeIV(tpfc), 0.44 V, −1.01 V (Epc), −1.60 V, −2.2 V (Epc); for ClFeIV(tdcc), 0.24 V, −1.18 V (Epc), −1.78 V vs SCE with a scan rate of 0.1 V s-1. Cyclic voltammetry in CO2-saturated solutions indicated that the CoI and FeI complexes react with CO2 and that the reduced Fe(tdcc) complex is the most efficient electrocatalyst for CO2 reduction, showing the largest catalytic currents among these corroles. Photochemical reduction in CO2-saturated acetonitrile solutions containing p-terphenyl (TP) as a sensitizer and triethylamine (TEA) as a reductant led to production of CO and H2. These experiments also show that Fe(tdcc) is more effective than the other corroles as a CO2 reduction catalyst. The present finding that the MI oxidation states of the cobalt and iron corroles can react with CO2 is in contrast with the case of the respective porphyrins and phthalocyanines, which do not react with CO2 until they are reduced beyond the MI state.
Inheritance in Erythropoietic Protoporphyria: A Common Wild-Type Ferrochelatase Allelic Variant With Low Expression Accounts for Clinical Manifestation (1999)

Erythropoietic protoporphyria (EPP) is a rare autosomal dominant disorder of heme biosynthesis characterized by partial decrease in ferrochelatase (FECH; EC 4.99.1.1) activity with protoporphyrin overproduction and consequent painful skin photosensitivity and rarely liver disease. EPP is normally inherited in an autosomal dominant pattern with low clinical penetrance; the many different mutations that have been identified are restricted to one FECH allele, with the other one being free of any mutations. However, clinical manifestations of dominant EPP cannot be simply a matter of FECH haploinsufficiency, because patients have enzyme levels that are lower than the expected 50%. From RNA analysis in one family with dominant EPP, we recently suggested that clinical expression required coinheritance of a normal FECH allele with low expression and a mutant FECH allele. We now show that (1) coinheritance of a FECH gene defect and a wild-type low-expressed allele is generally involved in the clinical expression of EPP; (2) the low-expressed allelic variant was strongly associated with a partial 5' haplotype [-251G IVS1-23T IVS2microsatA9] that may be ancestral and was present in an estimated 10% of a control group of Caucasian origin; and (3) haplotyping allows the absolute risk of developing the disease to be predicted for those inheriting FECH EPP mutations. EPP may thus be considered as an inherited disorder that does not strictly follow recessive or dominant rules. It may represent a model for phenotype modulation by mild variation in expression of the wild-type allele in autosomal dominant diseases.
Automatic Inference of Search Patterns for Taint-Style Vulnerabilities (2015)

Taint-style vulnerabilities are a persistent problem in software development, as the recently discovered "Heart bleed" vulnerability strikingly illustrates. In this class of vulnerabilities, attacker-controlled data is passed unsanitized from an input source to a sensitive sink. While simple instances of this vulnerability class can be detected automatically, more subtle defects involving data flow across several functions or project-specific APIs are mainly discovered by manual auditing. Different techniques have been proposed to accelerate this process by searching for typical patterns of vulnerable code. However, all of these approaches require a security expert to manually model and specify appropriate patterns in practice. In this paper, we propose a method for automatically inferring search patterns for taint-style vulnerabilities in C code. Given a security-sensitive sink, such as a memory function, our method automatically identifies corresponding source-sink systems and constructs patterns that model the data flow and sanitization in these systems. The inferred patterns are expressed as traversals in a code property graph and enable efficiently searching for unsanitized data flows -- across several functions as well as with project-specific APIs. We demonstrate the efficacy of this approach in different experiments with 5 open-source projects. The inferred search patterns reduce the amount of code to inspect for finding known vulnerabilities by 94.9% and also enable us to uncover 8 previously unknown vulnerabilities.
Novel Roles for the AIDA Adhesin from Diarrheagenic<i>Escherichia coli</i>: Cell Aggregation and Biofilm Formation (2004)

Diarrhea-causing Escherichia coli strains are responsible for numerous cases of gastrointestinal disease and constitute a serious health problem throughout the world. The ability to recognize and attach to host intestinal surfaces is an essential step in the pathogenesis of such strains. AIDA is a potent bacterial adhesin associated with some diarrheagenic E. coli strains. AIDA mediates bacterial attachment to a broad variety of human and other mammalian cells. It is a surface-displayed autotransporter protein and belongs to the selected group of bacterial glycoproteins; only the glycosylated form binds to mammalian cells. Here, we show that AIDA possesses self-association characteristics and can mediate autoaggregation of E. coli cells. We demonstrate that intercellular AIDA-AIDA interaction is responsible for bacterial autoaggregation. Interestingly, AIDA-expressing cells can interact with antigen 43 (Ag43)-expressing cells, which is indicative of an intercellular AIDA-Ag43 interaction. Additionally, AIDA expression dramatically enhances biofilm formation by E. coli on abiotic surfaces in flow chambers.
40-wavelength rapidly digitally tunable laser (1999)

We present a tunable laser based on an N/sub 1//spl times/N/sub 2/ chirped waveguide grating router that has N/sub 1/N/sub 2/ wavelengths, accessible in a digitally rapid manner, and only N/sub 1/+N/sub 2/+1 semiconductor optical amplifiers. By using chirp, the free-spectral range of the router can be significantly less than the channel span. The version demonstrated here has N/sub 1/=5, N/sub 2/=8, a channel spacing of 100 GHz, and the router free-spectral range is only 20 channels.
Proteins of Epstein-Barr virus. I. Analysis of the polypeptides of purified enveloped Epstein-Barr virus (1976)

Epstein-Barr virus (EBV) was purified from the extracellular fluid of HR-1 and B95-8 cell lines. The preparations of purified virus consisted of enveloped particles and had EBV-specific antigneic reactivity. Comparison of the amount of labeled protein in preparations of virus purified from cultures incubated in [35S]methionine with the amount of labeled protein in preparations obtained following a mixture of unlabeled virus with [35S]methionine-labeled cellular proteins indicated that less than 2% of the labeled protein in the purified virus preparation could be attributed to contamination with labeled cellular proteins. No extraneous membranous material was seen in thin sections of the purified virus preparations. Analysis of the polypeptides of purified enveloped EBV indicated the following. (i) Eighteen polypeptides could be resolved in Coomassie brilliant blue-stained electropherograms of extracellular virus purified from HR-1 and B95-8 cultures. (ii) Thirty-three polypeptides could be resolved in fluorograms of labeled EBV purified from B95-8 cultures and subjected to electrophoresis in acrylamide gels cross-linked with diallyltartardiamide. The molecular weight of the EBV polypeptides was estimated by co-electrophoresis with the polypeptides of purified herpes simplex virus and purified polypeptides of known molecular weight to range from 28 x 10(3) to approximately 290 x 10(3) (iii) The polypeptides of EBV could be grouped by their relative molar abundancy into three classes: VP6, 7, and 27 present in high abundance; VP1, 12, 20, 23, and 29 present in moderate abundance; and a third class of less abundant polypeptides, VP4, 5, 8, 9, 10, 11, 15, 16, 21, and 22. The remainder of the polypeptides could not be precisely quantitated. (iv) The polypeptides of purified EBV, although similar in number and in range of molecular weight to the polypeptides of purified herpes simplex virus, differ sufficiently from those of herpes simplex virus so as to preclude comparison of individual polypeptide components.
Case 18-1976 (1976)

Presentation of CaseA 64-year-old man was admitted to the hospital because of renal disease.Ten years earlier mild hyperuricemia was found. Five years later he passed a renal stone. The urea nitrogen was 14 mg, the calcium 9.2 mg, and the uric acid 7.5 mg per 100 ml. During the four years before entry he had one episode of pain in the wrist and another of pain, swelling and redness of the great toe after minor trauma; there was no other history of joint pain.Nine months before admission he entered another hospital because of left renal colic. The . . .
Role of the Mannose‐Binding Lectin in Innate Immunity (2003)

The ability to recognize infectious agents from self is intrinsic to innate immunity. One basic tenet of innate immunity is the evolution of classes of molecules that are termed "pattern-recognition" receptors and molecules. Many pattern-recognition molecules conspire together to protect the host in the first minutes and hours after exposure to an infectious challenge. The mannose-binding lectin (MBL; also termed "mannose-binding protein") is a prototypic pattern-recognition molecule that appears to play a role as an "ante-antibody" in first line host defense. The serum levels of the human MBL are regulated in serum so that any one person will display a phenotype of low, intermediate, or high levels. There appears to be a relationship between circulating MBL and susceptibility and resistance to infection. MBL levels also appear to be regulated by distinct haplotypes. Thus, the question to be answered is what constitutes the innate immunity haplotype in any individual and how does this impact on the relationship between the host and infectious agents?
Radar Signal Attenuation due to Finite Radome Thickness (2015)

Radar antennas deployed in real use usually include a protective dome, which shields them from potentially harmful weather conditions. The protective dome is typically constructed from a plastic material, which can affect the radar signal. The presented paper deals with signal attenuation caused by radar’s dome. It provides results of a computer simulation concerning this attenuation based on different thickness of the material used for radome construction. The presented results give insight on the impact of different radome material thickness on overall radar aperture gain.
Removal of pulmonary artery band. (1975)

From 1963 to September 1973, 60 patients underwent definitive repair of cardiac lesions for which pulmonary artery banding had been performed previously. Most bandings had been performed for intractable heart failure secondary to large pulmonary flow. The pulmonary artery band resulted in a fibrous reaction around the pulmonary artery or its branches in all instances. Angioplastic procedures on the main pulmonary artery or the left and right pulmonary arteries were usually necessary to relieve the stenosis produced by the band and the resultant scarring. The operative mortality in this group of patients was 28% and pulmonary artery banding was considered to be a factor in 4 of the 17 deaths. The absence of absolute protection from the development of progressive pulmonary vascular disease, the mortality associated with banding, and the mortality and increased technical difficulties associated with removing the band at the time of the repair support one-stage definitive procedures rather than palliative banding of the pulmonary arteries in all but the most exceptional situations.