gebhart/patrepeval huggingface dataset:
Precisely positioned light-induced self-written (LISW) polymeric optical waveguide for optical transceiver module fabrication (2006)

Plastic optical fibers (POFs) are beginning to replace electrical wiring in many automotive and home applications. In view of this, we have reported the inexpensive wavelength-division-multiplexing (WDM) device for POF system using the LISW waveguide. The LISW waveguides are an attractive and a low-cost process for realizing self alignment between a POF and a waveguide. In this study, we have investigated about the method for precisely aligned LISW polymeric optical waveguides by using an "optical solder" effect. The "optical solder" effect makes it possible to realize a waveguide connection between two faced optical fibers by radiating from both sides even if a significant gap and a small degree of misalignment exist. When we utilize POFs with core diameters of 700μm, waveguides are combinable on the condition that an offset is 700μm or less and a gap is from 6mm to 13mm. By applying this effect, we fabricated precisely positioned LISW waveguides for optical devices. The fiber ends were set at certain mounting positions with respect to the LEDs and PDs. And we evaluated the positioning accuracy. The resulting positional accuracy at the extremities of the optical waveguides is less than one-tenth of the optical fiber core diameter. This value is sufficiently accurate to realize passive alignment. And this result creates new possibilities for boosting the yield of optical modules in mass-production.
Synthesis, in vivo effects, metabolism, and excretion of 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole in the beagle dog (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, in vivo effects, metabolism, and excretion of 5-(p-hydroxyanilino)-1,2,3,4-thiatriazole in the beagle dogGeorge J. Ikeda, Charles B. Estep, Leo H. Wiemeler, and Arthur AlterCite this: J. Med. Chem. 1974, 17, 10, 1079–1082Publication Date (Print):October 1, 1974Publication History Published online1 May 2002Published inissue 1 October 1974https://doi.org/10.1021/jm00256a011RIGHTS & PERMISSIONSArticle Views47Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (557 KB) Get e-Alerts Get e-Alerts
Patellar Fixation Protected with a Load-Sharing Cable (1988)

The stability of patellar fracture fixation protected with a load-sharing cable was studied in cadavers. A transverse patellar osteotomy was produced and stabilized with standard patellar fixation with or without a figure-of-eight cable that extends from the proximal pole of the patella to the tibial tubercle. Standard fixation techniques (interfragmentary cancellous screws or modified tension-band wiring) alone failed after significantly fewer cycles of flexion and extension than did the same fixation when supplemented with a load-sharing cable. In the clinical evaluation of the load-sharing cable, 14 consecutive patients with displaced patellar fractures were treated. No immobilization was used and the patients were started on passive and active range of motion and weight-bearing ambulation in the early postoperative period. Thirteen fractures healed uneventfully. The increased stability of patellar fracture fixation protected with a load-sharing cable offers three advantages: (a) adjunctive casting is unnecessary, (b) comminuted fractures can be "pieced" together anatomically with less concern for loss of fixation, and (c) early postoperative passive and active range of motion can be achieved.
A trust-based approach to selection of business services (2011)

Abstract With the increasing popularity of the service-oriented thinking in the business area, an overwhelming number of business services have arisen. These business services collaborate with each other and form a business network or a service-oriented business ecosystem (SOBE). It is a key issue to select appropriate business services to share and integrate them in the SOBE. Trust degrees play an important role in the selection of business services. However, existing researches mainly focus on quality of service (QoS)-based selection methods and few of them take trust degrees into account. In order to select services more accurately, a trust-based approach for selection of business services is proposed based on the formal definition of the SOBE. First, the method for acquisition and calculation of trust values is developed. The method also considers other parameters including QoS attributes, the physical distance between users and business services and the waiting time. Second, one node in a business flow may need to select two or more business services to achieve the user's requirements. Thus, the multi-service selection method for one node is presented. Third, a fuzzy chance-constrained programming model is proposed for the selection of business services by considering four kinds of factors: QoS attributes, trust relationship, physical distance and waiting time. Using the characteristic of fuzzy constraints, a function is developed to convert the fuzzy chance constraints into its crisp equivalents and then the equivalent crisp model is solved by the generic algorithm (GA)-based algorithm. For the case in which no satisfying solution can be found by the GA-based algorithm, a negotiation method is proposed to reach at a satisfying solution. Finally, a case study is conducted to demonstrate the feasibility and effectiveness of the proposed approach. Keywords: business servicestrustservices selectionbusiness ecosystemfuzzy programming Acknowledgements The authors thank the anonymous reviewers for their useful suggestions and comments that improved this article. This work is supported by National Natural Science Foundation of China (Key Programme, No. 61033005), the National High Technology Research and Development Programme of China (863 Programme, No. 2009AA010308) and the National Key Technology R&D Programme (No. 2008BAH32B03–1).
The origin of cecropins; implications from synthetic peptides derived from ribosomal protein L1 (1999)

We recently showed that Helicobacter pylori grown on plates produce cecropin-like antibacterial peptides to which H. pylori is resistant. This antibacterial activity was traced to fragments from the N-terminus of ribosomal protein L1 (Pütsep et al., Nature, April 22, 1999). The evolutionary suggestion from this finding has now been extended by the synthesis of eight peptides with sequences taken from the N-terminus of ribosomal protein L1 (RpL1) of five different species. Two peptides of different length derived from H. pylori RpL1 showed a potent antibacterial activity, while a peptide with the sequence from Escherichia coli was 20 times less active. Like cecropins the H. pylori peptides were not cytolytic. We suggest that the cecropins have evolved from ribosomal protein L1 of an ancestral intracellular pathogen that developed to a symbiont ending as an organelle. When the R1 gene moved into the host nucleus, a duplication provided a copy from which today cecropins could have evolved.
Multiplicity of Progesterone's Actions and Receptors in the Mammalian Ovary1 (2006)

This minireview summarizes the role that progesterone (P4) plays in regulating granulosa and luteal cell function. These actions include the stimulation of P4 synthesis and the inhibition of estrogen synthesis, mitosis, and apoptosis. P4 also plays a key role in the ovulatory process. Although P4's actions are well documented, the mechanism or mechanisms that mediate all of these actions have not been defined. In addition to P4-induced gene transcription that is mediated by the nuclear P4 receptors (PGR-A and PGR-B), three other receptor/signal transduction pathways could account for P4's intraovarian actions. These pathways could be mediated by 1) the PGR localizing at or near the plasma membrane and activating SRC family kinases, 2) a membrane progestin receptor that responds to P4 by lowering intracellular cAMP and increasing MAPK 3/1 activity, and 3) a membrane receptor complex composed of serpine 1 mRNA binding protein (also known as PAIRBP1 or RDA288) and progesterone receptor membrane component 1. Ligand activation of this complex likely leads to an increase in protein kinase G activity, the maintenance of low basal intracellular free calcium, and the inhibition of granulosa and luteal cell mitosis and apoptosis. Given the complexity of P4's actions within the ovary, it is likely that all of these receptor/signal transduction pathways influence some aspect of ovarian function with the specific P4 response dependent on 1) the expression pattern of these putative P4 receptors, 2) the P4 binding affinity of each receptor system, and 3) the amount of available P4.
Review of antiplatelet drug use in preventing restenosis following percutaneous transluminal coronary angioplasty. (1988)

Although percutaneous transluminal coronary angioplasty is a widely accepted form of therapy for coronary artery disease, there is a 30% restenosis rate associated with it. The pathobiological processes that are triggered following coronary angioplasty are related to platelet-vessel wall interactions, coagulation, endothelial injury and smooth muscle cell modulation and proliferation. These events are reviewed with respect to the role of platelets and the products they release at the site of endothelial injury. Various families of antiplatelet drugs are discussed with regard to the rationale for their use and the results reported in patients undergoing percutaneous transluminal coronary angioplasty. The major conclusion is that a variety of processes are likely to be responsible for restenosis. Acetylsalicylic acid has been shown to be effective in reducing cardiovascular disease conditions associated with thrombosis and may effect reductions in restenosis through its inhibition of this process. Current pharmacologic regimens do not significantly reduce the incidence of smooth muscle cell proliferation, an important feature of long term stenosis. The role of new, more specific antiplatelet drugs as well as innovations in instrumental technology may hold future promise in reducing rates of restenosis.
Rocksteady (2017)

Scalable in-memory key-value stores provide low-latency access times of a few microseconds and perform millions of operations per second per server. With all data in memory, these systems should provide a high level of reconfigurability. Ideally, they should scale up, scale down, and rebalance load more rapidly and flexibly than disk-based systems. Rapid reconfiguration is especially important in these systems since a) DRAM is expensive and b) they are the last defense against highly dynamic workloads that suffer from hot spots, skew, and unpredictable load. However, so far, work on in-memory key-value stores has generally focused on performance and availability, leaving reconfiguration as a secondary concern.
Arichitecture (1941)

Journal Article Arichitecture Get access Hagia Sophia. By EMERSON HOWLAND SWIFT. New York: Columbia University Press, 1940. xviii + 265 pages. Frontispiece and 46 plates. 34 illustrations in the text. Bibliography and index. Price $10.00. PHILIP BARROW WHITEHEAD PHILIP BARROW WHITEHEAD Beloit College Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume IX, Issue 4, November 1941, Pages 244–245, https://doi.org/10.1093/jaarel/IX.4.244 Published: 01 November 1941
Low threshold voltage CMOS devices with smooth topography for 1 volt applications (2002)

CMOS devices with ultra-low threshold voltage, high performance, and smooth topography are fabricated for 1 volt applications. Novel features of the devices include (1) enhanced self-aligned twin-tub with low surface dopant level, deep concentration profile, and low n-p tub boundary height, (2) dual-gate implant with wafer tilted to achieve thin gate height while suppressing ion penetration, and (3) use of hard-mask and sidewall dielectrics to protect the TiN dual-gate shunt layer against oxidation. Excellent device characteristics has been demonstrated in this work.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Higher EducationAnd World Community (1981)

Editor's note- The following was excerpted from the Fourth Mordecai Wyatt Johnson Memorial Lecture which was delivered on January 23 on the campus of Howard University by historian John Hope Franklin.
Surface modified multifunctional nanomedicines for simultaneousimaging and therapy of cancer (2014)

Seamless multimodal NSs have potential to simultaneously target and monitor the tumor cells through homing and imaging/sensing devices and deliver the therapeutic agents. However, to achieve superior pharmacokinetics with maximal efficacy and minimal side effects, these advanced NSs need to become much more intelligent to sense the disease condition and liberate therapeutics on demand.
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors. (1975)

Rats bearing Reuber H-35 or Novikoff hepatomas and mice bearing L1210 or L5178Y murine leukemias exhibited elevated serum levels of fetuin : N-acetylneuraminic acid transferase (EC 2.4.99.1) activity. The serum transferase activity could be correlated with the growth rate of the tumor; in animals bearing the more rapidly growing Novikoff hepatoma, activity was higher than in animals bearing the Reuber H-35 hepatoma. Higher transferase levels were also found in L1210 leukemic mice than in mice with the slightly slower growing L5178Y leukemia. Serum from rats bearing Reuber H-35 hepatoma and mice bearing L1210 murine leukemia had elevated levels of alpha- and beta-glucosidase (EC 3.2.1.20 and EC 3.2.1.21), alpha- and beta-galactosidase (EC 3.2.1.22 and (3.2.1.23), beta mannosidase (EC 3.2.1.25), alpha- and beta-fucosidase (EC 3.2.1.- and EC 3.2.1.38), beta-N-acetylglucosaminidase (EC 3.2.1.30) and acid phosphatase (EC 3.1.3.2); alpha-mannosidase (EC 3.2.1.24), beta-N-acetylgalactosaminidase (EC 3.2.2.-) and beta-xylosidase (EC 3.2.1.37) were not elevated. In animals bearing Reuber H-35 hepatoma, host liver levels of glycosidases, beta-glucuronidase (EC 3.2.1.31) and acid phosphatase were elevated over both the control and the hepatoma values. The data are interpreted to mean that the tumors or various host tissues release large quantities of enzymes into the serum and that enzyme levels in host organs may also be affected by the tumor.
An adaptive map-matching algorithm based on hierarchical fuzzy system from vehicular GPS data (2017)

An improved hierarchical fuzzy inference method based on C-measure map-matching algorithm is proposed in this paper, in which the C-measure represents the certainty or probability of the vehicle traveling on the actual road. A strategy is firstly introduced to use historical positioning information to employ curve-curve matching between vehicle trajectories and shapes of candidate roads. It improves matching performance by overcoming the disadvantage of traditional map-matching algorithm only considering current information. An average historical distance is used to measure similarity between vehicle trajectories and road shape. The input of system includes three variables: distance between position point and candidate roads, angle between driving heading and road direction, and average distance. As the number of fuzzy rules will increase exponentially when adding average distance as a variable, a hierarchical fuzzy inference system is then applied to reduce fuzzy rules and improve the calculation efficiency. Additionally, a learning process is updated to support the algorithm. Finally, a case study contains four different routes in Beijing city is used to validate the effectiveness and superiority of the proposed method.
Design Consideration on Broad-Band W-Type Two-Mode Optical Fibers (1982)

Structural design for broad-band W-type two-mode optical fibers is investigated. The optimum parameters are numerically determined as follows: the operating V-value with zero group delay time difference Delta lambda between the LP/sub 01/ and LP/sub 11/ modes is 6.7, the ratio of core radius to inner cladding radius is 0.6, and the index profile parameter is 2.02. then, the core radius is 12.3 µm for Delta=0.3 percent at the operating wavelength of 1.3 µm. The V-value deviation tolerance from the optimum to maintain Delta lambda less than +-20 ps/km is 21 percent, which is 20 times larger than that of the earlier design made on two-layer index profile.
<sup>18</sup>F- and <sup>68</sup>Ga-Labeled Neurotensin Peptides for PET Imaging of Neurotensin Receptor 1 (2016)

The neurotensin (NT) receptor-1 (NTS1) is overexpressed in a variety of carcinomas and is therefore an interesting target for imaging with positron emission tomography (PET). The aim of this study was the development of new NT derivatives based on the metabolically stable peptide sequence NLys-Lys-Pro-Tyr-Tle-Leu suitable for PET imaging. The NT peptides were synthesized by solid-phase supported peptide synthesis and elongated with respective chelators (NODA-GA, DOTA) for (68)Ga-labeling or propargylglycine for (18)F-labeling via copper-catalyzed azide-alkyne cycloaddition. Receptor affinities of the peptides for NTS1 were in the range of 19-110 nM. Biodistribution studies using HT29 tumor-bearing mice showed highest tumor uptake for [(68)Ga]6 and [(68)Ga]8 and specific binding in small-animal PET studies. The tumor uptake of (68)Ga-labeled peptides in vivo significantly correlated with the in vitro Ki values for NTS1. [(68)Ga]8 displayed an excellent tumor-to-background ratio and could therefore be considered as an appropriate molecular probe for NTS1 imaging by PET.
Male menopause (1997)

There has been a recent explosion of articles in the medical literature and newsbites on television and in the lay press regarding male menopause. Yet, many men are not familiar with the changes in sexuality that accompany aging. Primary care physicians therefore need to be well informed about the concept of male menopause and the dos, don'ts, and unknowns of treating it with testosterone.
Comparative effects of plateletderived growth factor‐BB and insulin‐like growth factor‐I, individually and in combination, on periodontal regeneration in <i>Macaca fascicularis</i> (1996)

Platelet-derived growth factor (PDGF) and insulin-like growth factor I (IGF-I) in combination have previously been shown to enhance periodontal regeneration. The objective of this study was to further characterize the biological effects of this combination of growth factors in non-human primates and compare the effects to those of each growth factor individually. Ligature-induced periodontitis was initiated in 10 cynomolgus monkeys. After periodontal lesions were established, surgery was performed, and either a methylcellulose gel vehicle or vehicle containing 10 micrograms each of either PDGF-BB, IGF-I or both PDGF-BB and IGF-I was applied to exposed root surfaces. Biopsies were taken 4 and 12 wk after treatment and the extent of periodontal regeneration was assessed by histomorphometry. At both 4 and 12 wk vehicle-treated lesions generally revealed minimal osseous defect fill (ODF) (8.5 +/- 2.1% and 14.5 +/- 5.7%, respectively) and new attachment (NA) (34.1 +/- 5.2% and 26.6 +/- 10.5%, respectively). IGF-I treatment did not significantly alter healing compared to vehicle in any parameter at both 4 and 12 wk. PDGF-BB-treated sites exhibited significant (p < 0.05) regeneration of NA (69.6 + 12.0%) at 12 wk; trends for PDGF-BB treatment effect were also observed in other parameters at 4 and 12 wk, although these increases were not statistically significant. Treatment with PDGF-BB/IGF-I resulted in 21.6 +/- 5.1% and 42.5 +/- 8.3% ODF at 4 and 12 wk, respectively, and 64.1 +/- 7.7% and 74.6 +/- 7.4% NA at 4 and 12 wk, respectively (all significantly greater than vehicle, p < 0.05). The results from this study demonstrated that: 1) IGF-I alone at the dose tested did not significantly alter periodontal wound healing; 2) PDGF-BB alone significantly stimulated NA, with trends of effect on other parameters; and 3) the PDGF-BB/IGF-I combination resulted in significant increases in NA and ODF above vehicle at both 4 and 12 wk.
Generation of a Genotype VII Newcastle Disease Virus Vaccine Candidate with High Yield in Embryonated Chicken Eggs (2011)

To generate a genotype VII Newcastle disease virus (NDV) vaccine with high yield in embryonated chicken eggs, we selected genotype VII NDV strain JS5/05, which possesses a high virus titer in embryos as the parental virus. Using reverse genetics, we generated a genetically tagged derivative (NDV/AI4) of JS5/05 by changing the amino acid sequence of the cleavage site of the F0 protein. Pathogenicity tests showed that NDV/AI4 was completely avirulent. NDV/AI4 was genetically stable and replicated efficiently during 10 consecutive passages in embryos. More importantly, serologic assays showed that oil-emulsion NDV/AI4 induced higher hemagglutination inhibition (HI) titers against the prevalent virus than oil-emulsion LaSota vaccine in chickens and geese. Moreover, NDV/AI4-induced HI titers rose faster than those elicited by LaSota in chickens. Both NDV/AI4 and LaSota provided protection against clinical disease and mortality after the challenge with the genotype VII NDV strain JS3/05. However, NDV/AI4 significantly reduced virus shedding from the vaccinated birds compared to LaSota. Taken together, these results suggest that NDV/AI4 can provide better protection than LaSota and is a promising vaccine candidate against genotype VII NDV.