gebhart/patrepeval huggingface dataset:
ARID2: A new tumor suppressor gene in hepatocellular carcinoma (2011)

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.
A neural network regulator (1991)

The paper presents an architecture for neural network regulators. The back-propagation algorithm has been used in an integral hierarchical structure to perform I-O mapping and adaptation of controller parameters. This avoids the use of the sign of the plant errors during the back-propagation procedure, and prevents the generation of excessive control signals. It does not require a reference model or inverse system model, or the application of any probing signals. The neural network regulator has a compact structure, which can easily be extended to cater for more complex dynamic systems or additional control loops. The regulator has been evaluated by simulation on a detailed nonlinear model of a turbogenerator system. The results illustrate the good performance which may be achieved with the neural adaptive controller.<
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Interpretable Spatio-Temporal Attention for Video Action Recognition (2019)

Inspired by the observation that humans are able to process videos efficiently by only paying attention where and when it is needed, we propose an interpretable and easy plug-in spatial-temporal attention mechanism for video action recognition. For spatial attention, we learn a saliency mask to allow the model to focus on the most salient parts of the feature maps. For temporal attention, we employ a convolutional LSTM based attention mechanism to identify the most relevant frames from an input video. Further, we propose a set of regularizers to ensure that our attention mechanism attends to coherent regions in space and time. Our model not only improves video action recognition accuracy, but also localizes discriminative regions both spatially and temporally, despite being trained in a weakly-supervised manner with only classification labels (no bounding box labels or time frame temporal labels). We evaluate our approach on several public video action recognition datasets with ablation studies. Furthermore, we quantitatively and qualitatively evaluate our model's ability to localize discriminative regions spatially and critical frames temporally. Experimental results demonstrate the efficacy of our approach, showing superior or comparable accuracy with the state-of-the-art methods while increasing model interpretability.
Glomerular crescent-related biomarkers in a murine model of chronic graft versus host disease (2005)

These findings implicate these six genes in the development of glomerular crescents. More importantly, detection of Sparc, OPN and Lcn2 in urine may mean that these molecules could serve as important biomarkers for non-invasive diagnosis of glomerular crescents.
Model-based diagnostics for an aircraft auxiliary power unit (2003)

This paper describes a case study of model-based diagnostics system development for an aircraft auxiliary power unit (APU) turbine system. The off-line diagnostics algorithms described in the paper work with historical data of a flight cycle. The diagnostics algorithms use detailed engine systems models and fault model knowledge available to Honeywell as the engine manufacturer. The developed algorithms provide fault condition estimates that allow for consistent detection of incipient performance faults and abnormal conditions.
Virtual image display for flight simulation (1971)

Plastic lenses providing virtual image of flight scene for use in flight simulator with Schmidt projection system or television monitor
Tracking cycle: a new concept for simultaneous tracking of multiple moving objects in a typical traffic scene (2002)

Because of the complicated motion pattern of moving objects in a typical on-road traffic scene, detecting the real moving objects and properly tracking each one have become very difficult and always employ optical flows and fixed template matching to detect and track the moving objects. Unfortunately, it has to pay a huge calculation cost and can not deal with some complicated motion pattern like overlapping of tracked objects. A new concept of tracking cycle is proposed in the paper. With the continuous estimation of moving objects vitality and reliability values, our method can detect and track up to more than 30 moving objects in real time. The flexible dynamic template matching method is also presented in the paper, which makes our system faster and more efficient for real-time ITS applications. Experiments on real outdoor road scenes show the accuracy and efficiency of our approach.
Experiments in impulsive manipulation (2002)

In this paper, we present the results of our experimental effort in one form of impulsive manipulation: tapping. Our previous work studied the mechanics of tapping a planar object which then slides on a support surface, coming to rest due to friction. This work addresses the practical issues in creating a system which uses this mode of manipulation. We begin with the design of tapping devices-end effecters designed to deliver an impulse to an object, and report some of the issues we have found to be important in their design. Our next step was to perform single-tap experiments in order to fit and evaluate the models of impact and sliding. These experiments have shown that objects rotate less than predicted; we have found that the addition of a scaling factor for the torque due to friction enables the models to predict object motion reasonably well. In order to do positioning experiments, we developed a number of planning methods (or feedback control strategies) to compensate for errors in modeling, parameters, and actuation. These planning methods were successfully used to demonstrate a positioning task. We also have experimentally demonstrated that tapping can be used to position an object more precisely than the manipulator can position the tapping device. We offer some sensitivity analysis in support of this result.
SNIa Diversity: Theory and Diagnostics (1996)

Existing evidence of photometric and spectroscopic diversity among Type Ia supernovae is compared with the predictions from physical modeling of the explosions. Concerning light curves, changes in the central ignition density of massive (M ≃ Mch) C+O white dwarfs alone do not give appreciable variation. Spectroscopic diversity has been found in the nebular phase, the underluminous SN 1991bg providing an extreme case. A range of 0.4–0.8 M⊙ of 56Ni synthesized in the explosions is derived from the nebular spectra of a sample of SNe Ia. For SN 1991bg, however, a 56Ni mass of ∼ 0.1 M⊙ only is obtained. That leads us to explore models based on the detonation of low–mass WDs for this SN. Additionally, a nebular spectrum of SN 1991bg shows narrow Hα emission at the position of the SN. If this emission is confirmed against background contamination from the galaxy, it would be first evidence of a nondegenerate, H–rich companion in a SNIa.
Gut mucosal microbiome across stages of colorectal carcinogenesis (2015)

Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of the oral microbiome is primarily associated with CRC. Analysis of paired samples shows differences in community configurations between lesions and the adjacent mucosae. Correlations of bacterial taxa indicate early signs of dysbiosis in adenoma, and co-exclusive relationships are subsequently more common in cancer. We validate these alterations in CRC-associated microbiome by comparison with two previously published data sets. Our results suggest that a taxonomically defined microbial consortium is implicated in the development of CRC.
Vav3 oncogene is upregulated and a poor prognostic factor in breast cancer patients (2015)

The Vav3 oncogene is overexpressed and has a significant role in the tumorigenesis of prostate cancer and glioblastoma. In the present study, the expression status and prognostic value of Vav3 expression was investigated in breast cancer. Vav3 protein levels were analyzed by immunoblotting in human breast cancer and epithelial cell lines. Immunohistochemistry was used to detect Vav3 in a tissue microarray of 173 breast cancers and 19 benign breast lesions. Statistical analysis was performed to reveal the association between Vav3 expression and clinicopathological parameters. Disease-free survival (DFS) and overall survival (OS) were calculated by Kaplan-Meier analysis and the Cox regression model. The Vav3 protein level was higher in the breast cancer cell lines than in the normal human breast cells. Vav3 was expressed in 86.1% of breast cancer patients, but in only 15.6% patients with benign breast disease. Patients with negative estrogen receptor expression, axillary lymph node involvement and a high tumor-node-metastasis stage demonstrated a higher positive rate of Vav3 expression. The Kaplan-Meier survival analysis revealed that patients with higher Vav3 expression exhibited shorter DFS and OS times. The multivariate Cox analysis revealed that Vav3 was a prognostic factor of survival. Overall, Vav3 was overexpressed in human breast cancer cells and this correlated with a shorter survival time, indicating that Vav3 is a biomarker of a poor prognosis for breast cancer patients.
The Receptor for Advanced Glycation End Products (RAGE) Affects T Cell Differentiation in OVA Induced Asthma (2014)

The receptor for glycation end products (RAGE) has been previously implicated in shaping the adaptive immune response. RAGE is expressed in T cells after activation and constitutively in T cells from patients with diabetes. The effects of RAGE on adaptive immune responses are not clear: Previous reports show that RAGE blockade affects Th1 responses. To clarify the role of RAGE in adaptive immune responses and the mechanisms of its effects, we examined whether RAGE plays a role in T cell activation in a Th2 response involving ovalbumin (OVA)-induced asthma in mice. WT and RAGE deficient wild-type and OT-II mice, expressing a T cell receptor specific for OVA, were immunized intranasally with OVA. Lung cellular infiltration and T cell responses were analyzed by immunostaining, FACS, and multiplex bead analyses for cytokines. RAGE deficient mice showed reduced cellular infiltration in the bronchial alveolar lavage fluid and impaired T cell activation in the mediastinal lymph nodes when compared with WT mice. In addition, RAGE deficiency resulted in reduced OT-II T cell infiltration of the lung and impaired IFNc and IL-5 production when compared with WT mice and reduced infiltration when transferred into WT hosts. When cultured under conditions favoring the differentiation of T cells subsets, RAGE deficient T cells showed reduced production of IFNc but increased production of IL-17. Our data show a stimulatory role for RAGE in T activation in OVA-induced asthma. This role is largely mediated by the effects of RAGE on T cell proliferation and differentiation. These findings suggest that RAGE may play a regulatory role in T cell responses following immune activation.
Blind equalization of constant modulus signals using an adaptive observer approach (1996)

The paper addresses the problem of blind equalization of constant modulus signals which are degraded by frequency selective multipath propagation and additive white noise. An adaptive observer is used to update the weights of an FIR equalizer in order to restore the signal's constant modulus property. The observer gain is selected using fake algebraic Riccati methods in order to guarantee local stability. The performance of this method is compared to the constant modulus algorithm for simulated FM-FDM signals and exhibits significantly better convergence properties, particularly for heavy-tailed noise.
Composed ensembles of random unitary matrices (1998)

Composed ensembles of random unitary matrices are defined via products of matrices, each pertaining to a given canonical circular ensemble of Dyson. We investigate statistical properties of spectra of some composed ensembles and demonstrate their physical relevance. We discuss also the methods of generating random matrices distributed according to invariant Haar measure on the orthogonal and unitary group.
Fluoxetine effects on cerebral glucose metabolism (1994)

In a counterbalanced, double-blind, placebo-controlled trial, 40 mg of fluoxetine was administered to four healthy adult volunteers (three men, one woman; age range 20-39 years), 90 min before injection of 6-7.5 mCi of [18F]-2-deoxyglucose to measure cerebral metabolic rate of glucose (CMRglu). Subjects were engaged in a visual monitoring task shortly before and during scanning with a PETT-VI tomograph. Global CMRglu did not differ when placebo (8.93 +/- 0.96 mg 100 g-1 min-1) was compared to fluoxetine (8.22 +/- 0.86 mg 100 g-1 min-1; paired t-test = 0.82, df = 3, p < 0.48). However, statistical parametric mapping of differences in CMRglu between placebo and fluoxetine conditions revealed regional effects of fluoxetine shown by decreased metabolism in the amygdaloid complex, hippocampal formation and ventral striatum, and by increased metabolism centered in the right superior parietal lobe (Brodmann area 7). Parametric mapping for use in PET studies of glucose metabolism represents a significant new tool for studying drug effects in humans.
Microwave-driven ferromagnet–topological-insulator heterostructures: The prospect for giant spin battery effect and quantized charge pump devices (2010)

We study heterostructures where a two-dimensional topological insulator (TI) is attached to two normal-metal (NM) electrodes while an island of a ferromagnetic insulator (FI) with precessing magnetization covers a portion of its lateral edges to induce time-dependent exchange field underneath via the magnetic proximity effect. When the FI island covers both lateral edges, such device pumps pure spin current in the absence of any bias voltage, thereby acting as an efficient spin battery with giant output current even at very small microwave power input driving the precession. When only one lateral edge is covered by the FI island, both charge and spin current are pumped into the NM electrodes. We delineate conditions for the corresponding conductances (current-to-microwave-frequency ratio) to be quantized in a wide interval of precession cone angles, which is robust with respect to weak disorder and can be further extended by changes in device geometry. The origin of the quantization is explained using spatial profiles of local spin and charge currents in the reference frame rotating with the magnetization, which concomitantly reveals how current exiting from the chiral spin-filtered edge states within the TI region remains largely confined to a narrow flux within the NM electrodes that is refracted at the $\text{TI}\ensuremath{\mid}\text{NM}$ interface.
FEM simulation of bimodal and trimodal thermally conductive adhesives (2009)

A simulation with combination of a finite element analysis of Thermally Conductive Adhesive and contact resistance modeling has been presented. Using ANSYS and MATLAB software thermal conductivity and electrical resistivity of Conductive Adhesives with Ag filler and Epoxy matrix has been calculated. Thermally Conductive Adhesives are used as a thermal interface material to provide a better conduction and heat transfer between two surfaces. The results show that the conductivity dependency is relatively high for different filler shape and alignment. Discussed models are bimodal, Ag flakes and Ag spherical micro particles and trimodal with Multi-WallCNT nano particles.
Regulation of the BamHI restriction-modification system by a small intergenic open reading frame, bamHIC, in both Escherichia coli and Bacillus subtilis (1992)

BamHI, from Bacillus amyloliquefaciens H, is a type II restriction-modification system recognizing and cleaving the sequence G--GATCC. The BamHI restriction-modification system contains divergently transcribed endonuclease and methylase genes along with a small open reading frame oriented in the direction of the endonuclease gene. The small open reading frame has been designated bamHIC (for BamHI controlling element). It acts as both a positive activator of endonuclease expression and a negative repressor of methylase expression of BamHI clones in Escherichia coli. Methylase activity increased 15-fold and endonuclease activity decreased 100-fold when bamHIC was inactivated. The normal levels of activity for both methylase and endonuclease were restored by supplying bamHIC in trans. The BamHI restriction-modification system was transferred into Bacillus subtilis, where bamHIC also regulated endonuclease expression when present on multicopy plasmid vectors or integrated into the chromosome. In B. subtilis, disruption of bamHIC caused at least a 1,000-fold decrease in endonuclease activity; activity was partially restored by supplying bamHIC in trans.
Noninfectious Endophthalmitis Associated With Intravitreal Triamcinolone Injection (2003)

It may be appropriate to closely observe noninfectious, toxic endophthalmitis in patients treated with intravitreal triamcinolone before assuming it to be infectious, especially in the absence of eye pain.
Hidden Fungi, Emergent Properties: Endophytes and Microbiomes (2011)

Endophytes are microorganisms that live within plant tissues without causing symptoms of disease. They are important components of plant microbiomes. Endophytes interact with, and overlap in function with, other core microbial groups that colonize plant tissues, e.g., mycorrhizal fungi, pathogens, epiphytes, and saprotrophs. Some fungal endophytes affect plant growth and plant responses to pathogens, herbivores, and environmental change; others produce useful or interesting secondary metabolites. Here, we focus on new techniques and approaches that can provide an integrative understanding of the role of fungal endophytes in the plant microbiome. Clavicipitaceous endophytes of grasses are not considered because they have unique properties distinct from other endophytes. Hidden from view and often overlooked, endophytes are emerging as their diversity, importance for plant growth and survival, and interactions with other organisms are revealed.
Photobioreactor design: Mixing, carbon utilization, and oxygen accumulation (1988)

Photobioreactor design and operation are discussed in terms of mixing, carbon utilization, and the accumulation of photosynthetically produced oxygen. The open raceway pond is the primary type of reactor considered; however small diameter (1-5 cm) horizontal glass tubular reactors are compared to ponds in several respects. These are representative of the diversity in photobioreactor design: low capital cost, open systems and high capital cost, closed systems. Two 100-m(2) raceways were operated to provide input data and to validate analytical results. With a planktonic Chlorella sp., no significant difference in productivity was noted between one pond mixed at 30 cm/s and another mixed from 1 to 30 cm/s. Thus, power consumption or CO(2) outgassing limits maximal mixing velocities. Mixing power inputs measured in 100-m(2) ponds agreed fairly well with those calculated by the use of Manning's equation. A typically configured tubular reactor flowing full (1 cm diameter, 30 cm/s) consumes 10 times as much energy as a typical pond (20 cm deep flowing at 20 cm/s). Tubular reactors that flow only partially full would be limited by large hydraulic head losses to very short sections (as little as 2 m length at 30 cm/s flow) or very low flow velocities. Open ponds have greater CO(2) storage capacity than tubular reactors because of their greater culture volume per square meter (100-300 L/m(2) vs. 8-40 L/m(2) for 1-5-cm tubes). However, after recarbonation, open ponds tend to desorb CO(2) to the atmosphere. Thus ponds must be operated at higher pH and lower alkalinity than would be possible with tubular reactors if cost of carbon is a constraint. The mass transfer coefficient, K(L), for CO(2) release through the surface of a 100-m(2) pond was determined to be 0.10 m/h. Oxygen buildup would be a serious problem with any enclosed reactor, especially small-diameter tubes. At maximal rates of photosynthesis, a 1-cm tubular reactor would accumulate 8-10 mg O(2)/L/min. This may result in concentrations of oxygen reaching 100 mg/L, even with very frequent gas exchange. In an open pond, dissolved oxygen rises much more slowly as a consequence of the much greater volume per unit surface area and the outgassing of oxygen to the atmosphere. The maximum concentration of dissolved oxygen is typically 25-40 mg/L. The major advantage of enclosed reactors lies in the potential for aseptic operation, a product value which justifies the expense. For most products of algal mass cultivation, open ponds are the only feasible photobioreactor design capable of meeting the economic and operating requirements of such systems, provided desirable species can be maintained.
Demands on hearing aid features—special signal processing for elderly users? (2003)

Age-related effects on several parameters of hearing aid provision, comprising the importance of various hearing aid attributes, the main reason for dissatisfaction, and a measure for aided performance, were examined. When comparing two subgroups of younger and elderly hearing aid users, a significant difference occurred for the importance of the attribute 'handling', whereas all other features examined showed only differences in trends. The question posed for the main reason for dissatisfaction with the hearing aids revealed no significant contrasts. Problems with the instruments in several listening situations were investigated by means of the Gothenburg Profile. Items related to communication in groups showed significant differences between younger and older subjects, but only non-significant contrasts remained when the mean hearing losses of the two subgroups were properly matched. Based on the data presented, some age-related concerns should be taken into account in hearing-aid provision for elderly users, but special signal processing does not seem to be necessary.
Synthesis and Characterization of Gadolinium Doped Zinc Oxide Nanorods Thin Films (2015)

ZnO nanorods (NRs) arrays were synthesized by chemical solution deposition (CSD) method on commercial glass substrate with ZnO thin film act as seed layer prepared by sol-gel spin coating. The effect of annealing temperature of 150°C, 250°C and 500°C, respectively, on the structural growth was investigated. The observation reveals the structural improvement as the annealing temperature increased. The influence of gadolinium doping to ZnO NRs arrays was explored upon the structural and optical features. The FESEM imaging along with XRD, AFM and UV-Vis analysis were conducted to dissect the information gained by performing a study case on various gadolinium doping content in the range of 1 at. % to 4 at. %. Based on the results, the correlation between the doping content were drawn in details in this paper.