gebhart/patrepeval huggingface dataset:
Prognostic Importance of <i>MN1</i> Transcript Levels, and Biologic Insights From <i>MN1</i>-Associated Gene and MicroRNA Expression Signatures in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study (2009)

PURPOSE To determine the prognostic importance of the meningioma 1 (MN1) gene expression levels in the context of other predictive molecular markers, and to derive MN1 associated gene- and microRNA-expression profiles in cytogenetically normal acute myeloid leukemia (CN-AML). PATIENTS AND METHODS MN1 expression was measured in 119 untreated primary CN-AML adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. Patients were also tested for FLT3, NPM1, CEBPA, and WT1 mutations, MLL partial tandem duplications, and BAALC and ERG expression. Gene- and microRNA-expression profiles were attained by performing genome-wide microarray assays. Patients were intensively treated on two first-line Cancer and Leukemia Group B clinical trials. Results Higher MN1 expression associated with NPM1 wild-type (P < .001), increased BAALC expression (P = .004), and less extramedullary involvement (P = .01). In multivariable analyses, higher MN1 expression associated with a lower complete remission rate (P = .005) after adjustment for WBC; shorter disease-free survival (P = .01) after adjustment for WT1 mutations, FLT3 internal tandem duplications (FLT3-ITD), and high ERG expression; and shorter survival (P = .04) after adjustment for WT1 and NPM1 mutations, FLT3-ITD, and WBC. Gene- and microRNA-expression profiles suggested that high MN1 expressers share features with high BAALC expressers and patients with wild-type NPM1. Higher MN1 expression also appears to be associated with genes and microRNAs that are active in aberrant macrophage/monocytoid function and differentiation. CONCLUSION MN1 expression independently predicts outcome in CN-AML patients. The MN1 gene- and microRNA-expression signatures suggest biologic features that could be exploited as therapeutic targets.
An architectural approach to building systems from COTS software components (1997)

As software systems become increasingly complex to build developers are turning more and more to integrating pre-built components from third party developers into their systems. This use of Commercial Off-The-Shelf (COTS) software components in system construction presents new challenges to system architects and designers. This paper is an experience report that describes issues raised when integrating COTS components, outlines strategies for integration, and presents some informal rules we have developed that ease the development and maintenance of such systems.
Ocular Anti-Inflammatory Actions of Matrine (1987)

Matrine is an alkaloid isolated from the root of Sophora subprostrata (Leguminosae) which has been used as a Chinese medicine for the treatment of inflammation. Instillation of 50 microliter of 1% matrine showed significant inhibition of ocular inflammation induced by lens proteins. Unlike corticosteroids, matrine did not facilitate the IOP recovery in rabbit eyes nor did it change the electrical potential difference across rabbit iris-ciliary body. These results indicate that matrine could become a safer ocular antiinflammatory agent than corticosteroids. Further, matrine was found to markedly increase the reaction time of a mouse placed on a hot plate. These results indicate that matrine could be used as an analgesic as well.
Filtration From Mud During Drilling (1954)

Abstract This paper describes experimental investigations conducted at the California Research Corporation's model oil well. The first part describes filter loss from several drilling muds through bore hole walls during mud circulation and drill string rotation. The effect of mud properties and drill string rotation with mud circulation is described. Filtration from a bore hole full of drilling mud, not circulating, but under pressure for extended time periods, is also discussed. The second part describes filter loss to permeable formations from beneath a drilling bit where filter cake has no opportunity to develop appreciable thickness. If potential flow theory is applied to predict filtrate invasion from this hole bottom, large invasions are calculated. But model well experimentation shows that filtrate invasion from the hole bottom is controlled by mud particles that penetrate the formation ahead of the bit. This experimentation provides data to estimate the effect of mud particle penetration on fluid loss to formation. The third part presents an estimate of mud filtration during drilling of a well. Introduction As oil wells are drilled by the rotary method, drilling mud circulates up the annulus between drill pipe and well wall. Drillers adjust mud density so that the pressure at the bottom of the mud column is several hundred psi greater than the pressure of reservoir fluid. As a result of this pressure difference, the liquid part of the mud filters into the rock around the bore and mud solids deposit as a filter cake on the well wall. For many reasons the petroleum industry, within the past 20 years, has spent much money and energy to determine the volume of mud filtrate that enters rock around the well bore and dedicated much research effort to reduce this volume. Among the reasons for attempts to determine the volume of mud filtrate and to reduce this volume are the following:If filtrate damages the permeability of oil sand, the resultant damage to oil well productivity will depend on the distance that the filtrate invades the oil sand; reduction of filtrate volume may, therefore, increase well productivity.Filtrate that penetrates shale sections may cause the shale to swell and to slough into the well bore. Uncontrolled sloughing may stick drill pipe. Reduction in filtrate volume may reduce drilling trouble.Electric log resistivity curves are changed by invasion of a mud filtrate; the change depends on the depth to which filtrate invades. Knowledge of this depth is necessary before resistivity logs can be interpreted accurately.
Towards optimized suppression of dephasing in systems subject to pulse timing constraints (2010)

We investigate the effectiveness of different dynamical decoupling protocols for storage of a single qubit in the presence of a purely dephasing bosonic bath, with emphasis on comparing quantum coherence preservation under uniform versus nonuniform delay times between pulses. In the limit of instantaneous bit-flip pulses, this is accomplished by establishing a different representation of the controlled qubit evolution, where the decoherence behavior after an arbitrary number of pulses is directly expressed in terms of the uncontrolled decoherence function. In particular, analytical expressions are obtained for approximation of the long- and short-term coherence behavior for both Ohmic and supra-Ohmic environments. By focusing on the realistic case of pure dephasing in an excitonic qubit, we quantitatively assess the impact of physical constraints on achievable pulse separations, and show that little advantage of high-level decoupling schemes based on concatenated or optimal design may be expected if pulses cannot be applied sufficiently fast. In such constrained scenarios, we demonstrate how simple modifications of repeated periodic-echo protocols can offer significantly improved coherence preservation in realistic parameter regimes. We expect similar conclusions to be relevant to other constrained qubit devices exposed to quantum or classical phase noise.
The Impact of Punctal Occlusion on Soft Contact Lens Wearing Comfort and the Tear Film (2008)

Results comparing the sham and plug groups were not significantly different from each other with regards to the questionnaire score and treatment benefit assessment, indicating either the treatment effect was not detected, although present, or punctal occlusion had no treatment effect at all.
Aromatic amine route is environmentally safer (1992)

RETURN TO ISSUEPREVNewsNEXTAromatic amine route is environmentally saferSTU BORMANCite this: Chem. Eng. News 1992, 70, 48, 26–27Publication Date (Print):November 30, 1992Publication History Published online10 November 2010Published inissue 30 November 1992https://doi.org/10.1021/cen-v070n048.p026Copyright © 1992 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) SUBJECTS:Amines,Aromatic compounds Get e-Alerts
Solvent perturbation fluorescence immunoassay technique (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent perturbation fluorescence immunoassay techniqueClarke J. Halfman, Franklin C. L. Wong, and Dennis W. JayCite this: Anal. Chem. 1985, 57, 9, 1928–1930Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/ac00286a031https://doi.org/10.1021/ac00286a031research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Accurate modelling of Pd(0) + PhX oxidative addition kinetics (2010)

We have used dispersion-corrected DFT (DFT-D) together with solvation to examine possible mechanisms for reaction of PhX (X = Cl, Br, I) with Pd(P(t)Bu(3))(2) and compare our results to recently published kinetic data (F. Barrios-Landeros, B. P. Carrow and J. F. Hartwig, J. Am. Chem. Soc., 2009, 131, 8141-8154). The calculated activation free energies agree near-quantitatively with experimentally observed rate constants.
Utilization of an auxotrophic strain of the yeast <b> <i>Yarrowia lipolytica</i> </b> to improve γ‐decalactone production yields (1997)

gamma-Decalactone is an aroma compound with a pleasant peachy odour. Most industrial processes use the bioconversion of ricinoleic acid by yeasts to produce gamma-decalactone. Peroxisomal beta-oxidation activity is responsible for the bioconversion. Some yeasts, Yarrowia lipolytica in particular, grow during the bioconversion, yielding a low bioconversion rate. Auxotrophy for uracil of a genetically engineered Y. lipolytica strain was used to prevent growth in the bioconversion medium. beta-Oxidation activities and gamma-decalactone production of the auxotrophic strain were measured and compared with a wild-type strain in media supplemented or not. Induction of beta-oxidation was observed in the non-supplemented medium, although to a lesser extent than in supplemented medium. Aroma productivity of the auxotrophic strain in the supplemented medium was similar to that observed for the wild-type strain in both media. However, in the non-supplemented medium the productivity of the auxotrophic strain was 10-20-fold higher.
Water Exchange and Rotational Dynamics of the Dimeric Gadolinium(III) Complex [BO{Gd(DO3A)(H<sub>2</sub>O)}<sub>2</sub>]:  A Variable-Temperature and -Pressure <sup>17</sup>O NMR Study<sup>1</sup> (1996)

Rapid water exchange and slow rotation are essential for high relaxivity MRI contrast agents. A variable-temperature and -pressure (17)O NMR study at 14.1, 9.4, and 1.4 T has been performed on the dimeric BO(DO3A)(2), 2,11-dihydroxy-4,9-dioxa-1,12-bis[1,4,7,10-tetraaza-4,7,10-tris(carboxymethyl)cyclododecyl]dodecane, complex of Gd(III). This complex is of relevance to MRI as an attempt to gain higher (1)H relaxivity by slowing down the rotation of the molecule compared to monomeric Gd(III) complexes used as contrast agents. From the (17)O NMR longitudinal and transverse relaxation rates and chemical shifts we determined the parameters characterizing water exchange kinetics and the rotational motion of the complex, both of which influence (1)H relaxivity. The rate constant and the activation enthalpy for the water exchange, k(ex) and DeltaH(), are (1.0 +/- 0.1) x 10(6) s(-)(1)and (30.0 +/- 0.2) kJ mol(-)(1), respectively, and the activation volume, DeltaV(), of the process is (+0.5 +/- 0.2) cm(3) mol(-)(1), indicating an interchange mechanism. The rotational correlation time becomes about three times longer compared to monomeric Gd(III) polyamino-polyacetate complexes studied so far: tau(R) = (250 +/- 5) ps, which results in an enhanced proton relaxivity by raising the correlation time for the paramagnetic interaction.
Nerve Growth Factor from Cobra Venom Inhibits the Growth of Ehrlich Tumor in Mice (2014)

The effects of nerve growth factor (NGF) from cobra venom (cvNGF) on growth of Ehrlich ascites carcinoma (EAC) cells inoculated subcutaneously in mice have been studied. The carcinoma growth slows down, but does not stop, during a course of cvNGF injections and restores after the course has been discontinued. The maximal anti-tumor effect has been observed at a dose of 8 nmoles cvNGF/kg body weight. cvNGF does not impact on lifespan of mice with grafted EAC cells. K252a, a tyrosine kinase inhibitor, attenuates the anti-tumor effect of cvNGF indicating the involvement of TrkA receptors in the process. cvNGF has induced also increase in body weight of the experimental animals. In overall, cvNGF shows the anti-tumor and weight-increasing effects which are opposite to those described for mammalian NGF (mNGF). However in experiments on breast cancer cell line MCF-7 cvNGF showed the same proliferative effects as mNGF and had no cytotoxic action on tumor cells in vitro. These data suggest that cvNGF slows down EAC growth via an indirect mechanism in which TrkA receptors are involved.
A novel control method to minimize distortion in AC inverters (2002)

In PWM AC inverters, the duty-cycle modulator transfer function must be highly linear to achieve low distortion. Current-mode (CM) control, inherently nonlinear, is needed to actively "damp" otherwise high-Q LC noise-reduction filters. A novel current-mode control approach is proposed which tailors external ramp characteristics to achieve "perfect" transfer function linearity regardless of duty cycle, and guarantee sub-harmonic stability. Supporting mathematical analysis and prototype measurements are included. The method when applied to DC/DC converters provides fixed gain-bandwidth in continuous conduction mode over a broad line and load range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Discrimination of intact mycobacteria at the strain level: A combined MALDI‐TOF MS and biostatistical analysis (2006)

New methodologies for surveillance and identification of Mycobacterium tuberculosis are required to stem the spread of disease worldwide. In addition, the ability to discriminate mycobacteria at the strain level may be important to contact or source case investigations. To this end, we are developing MALDI-TOF MS methods for the identification of M. tuberculosis in culture. In this report, we describe the application of MALDI-TOF MS, as well as statistical analysis including linear discriminant and random forest analysis, to 16 medically relevant strains from four species of mycobacteria, M. tuberculosis, M. avium, M. intracellulare, and M. kansasii. Although species discrimination can be accomplished on the basis of unique m/z values observed in the MS fingerprint spectrum, discrimination at the strain level is predicted on the relative abundance of shared m/z values among strains within a species. For the 16 mycobacterial strains investigated in the present study, it is possible to unambiguously identify strains within a species on the basis of MALDI-TOF MS data. The error rate for classification of individual strains using linear discriminant analysis was 0.053 using 37 m/z variables, whereas the error rate for classification of individual strains using random forest analysis was 0.023 using only 18 m/z variables. In addition, using random forest analysis of MALDI-TOF MS data, it was possible to correctly classify bacterial strains as either M. tuberculosis or non-tuberculous with 100% accuracy.
Tracking and identification of suspicious and abnormal behaviors using supervised machine learning technique (2009)

The explosion in popularity of open systems interconnected via the pubic network and private network has made computer security an issue of increasing concern. In networks there is a major issue to secure the public or private network from suspicious behaviors. This is because each network is made of users, services and computers with a specific behavior that is then reflected in the generated network traffic to detect abnormal user suspicious detection system is used. This paper presents a supervised learning technique which is used to detect various suspicions and abnormal behaviors in the public or private networks. Our technique also detect various behaviors of these hosts using supervised learning methodology.
Amino Acid Sequence and Carbohydrate Structure of a Recombinant Human Tissue Factor Pathway Inhibitor Expressed in Chinese Hamster Ovary Cells:  One <i>N</i>- and Two <i>O</i>-Linked Carbohydrate Chains Are Located between Kunitz Domains 2 and 3 and One <i>N</i>-Linked Carbohydrate Chain Is in Kunitz Domain 2 (1996)

Human tissue factor pathway inhibitor is a protease inhibitor with three tandem Kunitz-type inhibitory domains. The recombinant protein (r-hTFPI) was produced using Chinese hamster ovary cells, and its polypeptide and carbohydrate chain structures were analyzed. The complete amino acid sequence, composed of 276 residues, was determined using a protein sequencer after protease digestion and it was identical to that predicted from the cDNA sequence. Among three potential N-glycosylation sites, both Asn117 and Asn167 were fully N-glycosylated but Asn228 was not. Thr175 was also fully O-glycosylated, but Ser174 was partially O-glycosylated. Carbohydrate composition and mass spectrometric analyses of the undecapeptide OG-11 (residues Leu 170approximately Leu180) showed that two O-linked carbohydrate chains consisted of a type-1 core structure (Gal-GalNAc-Ser/Thr) with 0-3 mol of N-acetylneuraminic acid(s). The N-linked carbohydrate chains were analyzed by two-dimensional carbohydrate mapping combined with sequential glycosidase digestion, after the reducing-ends of carbohydrate residues were tagged with 2-aminopyridine and non-reducing-end sialic acids were removed with sialidase. All the N-linked structures in r-hTFPI were complex-type carbohydrate chains with one fucose residue attached to the reducing-end GlcNAc and consisted of bi-, tri-, and tetraantennary carbohydrate chains in the ratio 1.9:1.3:1.0. Fucosylated tri- and tetraantennary carbohydrate chains with one or two N-acetyllactosaminyl repeats were also found (30% of carbohydrate chains determined). Thus, the region between Kunitz domains 2 and 3 encoded by exon 7 was highly glycosylated by two O-linked carbohydrate chains at Ser174 and Thr175 and one N-linked carbohydrate chain at Asn167. These results indicated that the region is occupied by a cluster of three bulky and acidic carbohydrate chains.
<i>Ab</i> <i>initio</i> studies of the polarizabilities of retinal analogs (1994)

Axial components of the polarizability, hyperpolarizability, and second order hyperpolarizability of retinal model molecules are calculated using the ab initio coupled-perturbed Hartree–Fock theory. Conformational rearrangements are shown to affect some components in a systematic fashion. We also find that the general trend in the hyperpolarizability behavior as a function of protonation and charge transfer is in agreement with available experimental data. The second hyperpolarizability of the protonated Schiff base is found to be highly dependent on the adopted geometry optimization. We explore a possible explanation for this as well as present a brief discussion with regard to future experimental and theoretical developments towards the construction of molecularly based nonlinear optical devices.
Linguistic Inquiry and Word Count (LIWC2007) (2007)

Linguistic Inquiry and Word Count (LIWC) is a text analysis software program designed by James W. Pennebaker, Roger J. Booth, and Martha E. Francis. LIWC calculates the degree to which people use different categories of words across a wide array of texts, including emails, speeches, poems, or transcribed daily speech. With a click of a button, you can determine the degree any text uses positive or negative emotions, self-references, causal words, and 70 other language dimensions.
Chronic measurement of epidural pressure with an induction-powered oscillator transducer (1976)

An induction-powered oscillator transducer (IPOT) was designed for the chronic measurement of epidural pressure. The transducer was completely implantable so all pressure measurements were made through the intact skin. The IPOT had a linear pressure range from -50 to +200 cm H2O, was sensitive to 1 mm H2O and had a zero drift of less than 1 mm H2O/day under full load. Zero drift was minimized by using a hermetically-sealed metal bellows transducing element which was chemically treated to prevent corrosion and creep. The correlation between epidural pressure and intraventricular pressure was determined during the first 24 hours after implantation in six dogs. Epidural pressure was found to be a linear function of intraventricular fluid pressure. Epidural pressure and intraventricular pressure were essential equal provided the epidural wedge pressure was minimized by proper insertion of the transducer. The correlation between epidural pressure and intraventricular pressure was determined after chronic implantation in five dogs. Epidural pressure was a linear function of intraventricular pressure in the chronically implanted dogs, but epidural pressure was not equal to intraventricular pressure. After chronic implantation, the epidural pressure transducer was not responsive to changes in intraventricular pressure because of mechanical changes in the dura. The dura became stiff and non-compliant. Maximum correlation between epidural pressure and intraventricular fluid pressure in chronic implantations will depend on judicious material selection and mechanical design at the transducer-dura interface.