gebhart/patrepeval huggingface dataset:
Effects of Rifaximin Administration on the Intestinal Microbiota in Patients with Ulcerative Colitis (2002)

The effect of rifaximin on the intestinal bacterial population was studied in a clinical trial. Twelve patients with ulcerative colitis were administered rifaximin 1800 mg/day in 3 treatment periods of 10 days, each followed by 25 days of wash-out. Fecal samples were collected at the beginning and at the end of each treatment period to perform microbiological examinations. Titer variations of enterococci, coliforms, lactobacilli, bifidobacteria, Bacteroides spp., and Clostridium perfringens as well as their susceptibility to rifaximin during the different phases of the study were evaluated. The presence of Candida spp. was also monitored. After each wash-out period, concentrations of the intestinal microbial groups tested returned to initial values, showing that the administration of high doses of rifaximin does not significantly modify the colonic microbiota. Rifaximin-resistant isolates were also found, particularly in bacteria belonging to Bifidobacterium genus, included as probiotics in several fermented foods and in pharmaceutical preparations.
Antenna array pattern nulling by controlling both amplitude and phase using modified touring ant colony optimization algorithm (2004)

This paper presents an efficient method, based on the modified touring ant colony optimization algorithm, for null steering of linear antenna arrays by controlling both the amplitude and the phase of array elements. The maximum sidelobe level, the null depth level and the dynamic range ratio are taken into account in the pattern synthesis. Simulation results for Chebyshev patterns with the imposed single, multiple and broad nulls are given to show the effectiveness of the proposed method.
Impact of efalizumab on psoriasis-specific patient-reported outcomes. Results from three randomized, placebo-controlled clinical trials of moderate to severe plaque psoriasis. (2004)

The objective of this study was to document the disease burden associated with moderate to severe plaque psoriasis, and assess the impact of efalizumab psoriasis treatment in improving patient-reported outcomes. This included analysis of patient-reported dermatology-related quality of life (DRQL) and psoriasis symptom scores among patients with moderate to severe psoriasis participating in three phase III, randomized, double-blinded, parallel-group, placebo-controlled, multi-center clinical trials conducted to evaluate the efficacy and safety of efalizumab. A total of 1,242 patients with moderate to severe psoriasis treated either with efalizumab 1.0 mg/kg/wk or placebo were followed for 12 weeks. DRQL and psoriasis symptom severity were assessed at baseline (pre-treatment) and at the end of the first treatment phase (12 weeks). DRQL was measured using the Dermatology Life Quality Index (DLQI). Symptoms were measured using the Psoriasis Symptom Assessment (PSA) and an Itch scale. Disease burden was assessed at baseline by examining responses to individual questions of the DLQI, PSA, and Itch patient-reported outcome measures. The impact of treatment on disease burden was assessed over a 12-week double-blind study period by comparing changes in DLQI, PSA, and Itch scale scores between the active treatment and placebo groups. Patient-reported outcomes were also assessed during a 12-week extended treatment phase. Prior to treatment, the responses to DLQI and PSA items revealed significant disease burden. Greater than 90% of patients reported being embarrassed or self conscious because of their skin, 53% reported that their skin prevented them from working or studying. and 98% reported that scaling and itching was bothersome. Compared to placebo-treated patients, efalizumab-treated patients showed significant improvement in patient-reported outcomes, reducing the limitations and burden associated with moderate to severe psoriasis within each of the three studies, as measured by DLQI (p<0.001), PSA-Severity (p<0.001), PSA-Frequency (p<0.001), and Itch (p<0.001) scores. Across all measures, the proportion of patients that improved on both statistical and clinical criteria for meaningful improvement was at least twofold greater among efalizumab-treated patients than in placebo-treated patients. The benefit of efalizumab was maintained over the course of an additional 12 weeks during an extended treatment phase. In conclusion, patients with moderate to severe plaque psoriasis reported significant DRQL burden and symptom severity at baseline, but efalizumab significantly improved patient-reported DRQL and reduced the frequency and severity of psoriasis symptoms during 12-week double-blind and 12-week extended treatment periods.
Applying differential privacy to search queries in a policy based interactive framework (2009)

Web search logs are of growing importance to researchers as they help understanding search behavior and search engine performance. However, search logs typically contain sensitive information about users and therefore considerable caution must be exercised when considering releasing the logs to the research community. Current approaches to releasing search logs focus on either protecting the privacy of users or enhancing the utility of data to researchers. In this work, we address the privacy-utility tradeoff by providing safe access to search logs, instead of releasing them. We propose a policy based safe interactive framework built on semantic policies and differential privacy to allow researchers access to search logs, while maintaining the privacy of the users. Semantic policies are used to infer the higher levels of information that can be mined from a dataset based on the fields accessed by a researcher. The accessed fields are then used to build research profile(s) that guide the amount of privacy to be enforced using differential privacy. We show the additional utility that can be obtained in our framework by two demonstrative experiments that involve access to user level information. Our results indicate that valid research can be conducted in our framework without forgoing the privacy of individuals.
Oxidant Generation Predominates Around Calcifying Foci and Enhances Progression of Aortic Valve Calcification (2007)

Our data provide evidence that ROS, particularly hydrogen peroxide, potentiate AV calcification progression. However, tempol exhibited a paradoxical effect, exacerbating AV/vascular calcification, likely because of its induced increase in peroxide generation.
Review—Bipolar Plates for the Vanadium Redox Flow Battery (2021)

Bipolar plates are one of the key components of vanadium redox flow batteries. They electrically conduct and physically separate adjacent cells in series and provide structural support to the stack. Bipolar plates are exposed to harsh conditions due to the acidic vanadium electrolyte and high potential differences which occur in vanadium redox flow batteries. Therefore, the material needs to fulfil good electrical conductivity, sufficient impermeability and mechanical stability as well as long-term chemical and electrochemical resistivity. This review provides a comprehensive overview of carbon-polymer based composites which are preferentially applied for bipolar plates in the vanadium redox flow battery. It addresses the composite materials, their production, properties, degradation mechanisms, designs and costs. In addition, it covers challenges and potentials for further development and optimization.
Klinik und Behandlung desschweren akuten respiratorischen Syndroms (2003)

SARS is a new and highly contagious lung disease. It is crucial to be able to recognize the clinical appearance and the diagnostic features of this disease at an early stage, in order to prevent a further dissemination of the disease.
Immunologic Responses to Repeated Ivermectin Treatment in Patients with Onchocerciasis (1991)

To assess the effect of ivermectin treatment on the immunologic status of individuals with onchocerciasis, 27 patients from Guatemala were studied before and at 6-month intervals during 2 years of repeated semiannual treatment with ivermectin. T cell proliferative responses to onchocercal antigen increased transiently by 6 months (mean stimulation index [SI] rising from 4.17 to 12.81) but returned to preivermectin levels thereafter. Changes in SI to nonparasite antigen paralleled those induced by parasite antigen. There were also significant decreases in levels of blood eosinophils, polyclonal IgG and IgE, parasite-specific IgG antibody, and IgG subclass antibodies by the end of the study. This study emphasizes the apparent long-term safety of ivermectin by demonstrating the absence of immunopathogenic responses induced by repeated ivermectin treatments.
Externally Bonded Fiber-Reinforced Polymer for Rehabilitation of Corrosion Damaged Concrete Beams (2000)

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FFAS server: novel features and applications (2011)

The Fold and Function Assignment System (FFAS) server [Jaroszewski et al. (2005) FFAS03: a server for profile-profile sequence alignments. Nucleic Acids Research, 33, W284-W288] implements the algorithm for protein profile-profile alignment introduced originally in [Rychlewski et al. (2000) Comparison of sequence profiles. Strategies for structural predictions using sequence information. Protein Science: a Publication of the Protein Society, 9, 232-241]. Here, we present updates, changes and novel functionality added to the server since 2005 and discuss its new applications. The sequence database used to calculate sequence profiles was enriched by adding sets of publicly available metagenomic sequences. The profile of a user's protein can now be compared with ∼20 additional profile databases, including several complete proteomes, human proteins involved in genetic diseases and a database of microbial virulence factors. A newly developed interface uses a system of tabs, allowing the user to navigate multiple results pages, and also includes novel functionality, such as a dotplot graph viewer, modeling tools, an improved 3D alignment viewer and links to the database of structural similarities. The FFAS server was also optimized for speed: running times were reduced by an order of magnitude. The FFAS server, http://ffas.godziklab.org, has no log-in requirement, albeit there is an option to register and store results in individual, password-protected directories. Source code and Linux executables for the FFAS program are available for download from the FFAS server.
Non-uniform thermal properties of an alumina granule/epoxy potting compound (2010)

In harsh environments, including high shock and vibration, magnetic devices such as transformer coils are potted to enhance thermal performance and provide mechanical protection. One potting compound frequently used is epoxy containing alumina particles. A nominally isotropic and uniform potting compound consisting of about 70 to 80% by volume 14-28 mesh (0.6 to 1.2 mm across) alumina granules in low viscosity epoxy was tested to determine its thermal properties. Examination by optical microscopy revealed that there was significant variation in volume fraction of alumina particles by location. The specific heat and thermal conductivity of the compound were measured using a Differential Scanning Calorimeter and guarded heater method based on the ASTM D5470-06. The thermal properties were found to vary with time, location, and temperature; with the specific heat ranging from 1.00 J/g°C ± 14% at 25°C to 1.22 J/g°C ± 12% at 125°C and an apparent thermal conductivity of 2.56 W/m·K ± 23%. Users of such compounds should be aware that the thermal properties are not necessarily constant in time or uniform, and assuming that they are could lead to significant errors when modeling their performance.
The αVβ6 Integrin As A Novel Molecular Target For Colorectal Cancer (2005)

Recent advances in the treatment of colorectal cancer have resulted from a shift towards the use of molecular targeting strategies, with the identification of specific antigens critical for the development and progression of these tumors allowing the rational design of new therapeutic agents. The integrin receptor family provides very attractive targets for this 'magic bullet' approach, as they play key roles at all points during the malignant evolution of tumors, influencing growth, progression, angiogenesis and metastasis. One integrin in particular, alphaVbeta6, was recently shown to be upregulated in a model of colorectal tumor progression. Importantly, the consequences of this elevated receptor expression not only impact tumor cell function, but also indicate that alphaVbeta6 is a prognostic variable for colorectal cancer and one that is predictive of patient outcome in early-stage disease. Taken together with its normal expression pattern and known biologic functions, alphaVbeta6 thus emerges as a novel therapeutic candidate.
ReviewChain: Untampered Product Reviews on the Blockchain (2018)

Online portals include an increasing amount of user feedback in form of ratings and reviews. Recent research highlighted the importance of this feedback and confirmed that positive feedback improves product sales figures and thus its success. However, online portals' operators act as central authorities throughout the overall review process. In the worst case, operators can exclude users from submitting reviews, modify existing reviews, and introduce fake reviews by fictional consumers. This paper presents ReviewChain, a decentralized review approach. Our approach avoids central authorities by using blockchain technologies, decentralized apps and storage. Thereby, we enable users to submit and retrieve untampered reviews. We highlight the implementation challenges encountered when realizing our approach on the public Ethereum blockchain. For each implementation challange, we discuss possible design alternatives and their trade-offs regarding costs, security, and trustworthiness. Finally, we analyze which design decision should be chosen to support specific trade-offs and present resulting combinations of decentralized blockchain technologies, also with conventional centralized technologies.
Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor (2011)

The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon species.
Impact of admission month and hospital teaching status on outcomes in subarachnoid hemorrhage: evidence against the July effect (2011)

The discharge disposition among SAH admissions within the NIS was not suggestive of a July effect but did reveal that teaching institutions have significantly lower rates of adverse outcomes when compared with nonteaching hospitals. Note, however, that the origins of this difference related to teaching status remain unclear.
Peptide antibody specific for the amino terminus of skeletal muscle alpha-actin. (1983)

The NH2-terminal peptide of skeletal muscle alpha-actin (S alpha N peptide), which contains a primary sequence unique to this actin isozyme, was used to prepare an isozyme-specific peptide antibody. S alpha N peptide was purified from chicken breast muscle actin by preparative reverse-phase HPLC and was coupled to hemocyanin. This complex was used to immunize rabbits in order to elicit actin antibodies specific for the skeletal muscle alpha-actin isozyme. The antibody obtained, called S alpha N antibody, was reactive with S alpha N peptide and with skeletal muscle alpha-actin as well as with cardiac muscle alpha-actin. S alpha N antibody did not react with either of the actin isozymes present in smooth muscle (smooth muscle alpha and gamma) or in brain (nonmuscle beta and gamma). S alpha N antibody was used to detect muscle-specific actin in differentiating mouse and human myoblasts by using immunoblots of myoblast extracts and immunofluorescent staining of fixed cells.
Nonarteritic anterior ischemic optic neuropathy: cause, effect, and management (2017)

Nonarteritic anterior ischemic optic neuropathy (NAION) is the most common form of ischemic optic neuropathy and the second most common optic neuropathy. Patients are generally over the age of 50 years with vasculopathic risk factors (eg, diabetes mellitus, hypertension, and obstructive sleep apnea). The exact mechanism of NAION is not fully understood. In addition, several treatment options have been proposed. This article summarizes the current literature on the diagnosis, treatment, and management of NAION.
Application of the locus of a perturbed relay system to analysis and design of relay servo systems with nonlinear plants (2001)

The locus of a perturbed relay system (LPRS) method is being extended to nonlinear plant case in the paper. The nonlinear plant extension of this method is based on the main property and some other features of LPRS. A numeric integration approach is considered. An extended definition of LPRS for its open-loop output spectrum based computing is given. An example of design of the relay pneumatic servo system is considered in the paper.
Detection of substances with alcoholic or phenolic hydroxyl groups by generation of hydrogen peroxide with imidazole and peroxyoxalate chemiluminescence (1995)

On-line detection of substances with an alcoholic or phenolic hydroxyl group using imidazole and peroxyoxalate chemiluminescence was investigated qualitatively using a flow-injection method. The substances tested included six polyphenols, five monophenols and six sugars. After incubation at 80 degrees C with an imidazole buffer (pH 9.5) the substances were detected by peroxyoxalate chemiluminescence. The polyphenols tested (e.g., pyrogallol, purpurogallin, and dopamine) showed the strongest light emission. The sugars with hydroxyl groups (e.g., fructose and lactose) and the monophenols (e.g., phenol, serotonin, and beta-estradiol) produced only a weak light emission. Imidazole served two roles, it catalysed the reaction with the hydroxyl compound and initiated peroxyoxalate chemiluminescence on-line. A novel reactor formed by packing glass beads into a flow cell (Teflon) of a chemiluminometer improved the sensitivity of light detection.
[Experimental study of the anti-inflammatory and analgesic effects of diethyl 1,3-dicyclohexyl- 1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate]. (2012)

ZL-5010 administered by gavage has anti-inflammatory and analgesic effects in mice and rats, and in mouse peritoneal exudate cell cultures, the agent also inhibits the production of the pro-inflammatory cytokines IL-1β and TNF-α.
Study of UV‐shielding properties of novel porous hollow silica nanoparticle carriers for avermectin (2006)

The shielding protection given by self-prepared porous hollow silica nanoparticles (PHSN) to pesticides from degradation by UV light was investigated using avermectin as a model pesticide. It was demonstrated that PHSN carriers with a shell thickness of approximately 15 nm and a pore diameter of 4-5 nm have an encapsulation capacity of 625 g kg(-1) for avermectin using a supercritical fluid loading method. PHSN carriers exhibited remarkable UV-shielding properties for avermectin. This was affected by the intensity of UV light, the pH and the temperature of the release medium. Rises in UV intensity, pH and/or temperature reduced the UV protection of PHSN for avermectin. In addition, avermectin loaded into the inner core of the PHSN carriers was released slowly into the release medium for about 30 days following a typical sustained-release pattern. It thus appears that PHSN carriers have a promising future in applications requiring sustained pesticide release.
Clinical spectrum of impulse control disorders in Parkinson's disease (2014)

Impulse control disorders (ICDs), including compulsive gambling, buying, sexual behavior, and eating, are a serious and increasingly recognized psychiatric complication in Parkinson's disease (PD). Other impulsive-compulsive behaviors (ICBs) have been described in PD, including punding (stereotyped, repetitive, purposeless behaviors) and dopamine dysregulation syndrome (DDS; compulsive PD medication overuse). ICDs have been most closely related to the use of dopamine agonists (DAs), perhaps more so at higher doses; in contrast, DDS is primarily associated with shorter-acting, higher-potency dopaminergic medications, such as apomorphine and levodopa. Possible risk factors for ICDs include male sex, younger age and younger age at PD onset, a pre-PD history of ICDs, and a personal or family history of substance abuse, bipolar disorder, or gambling problems. Given the paucity of treatment options and potentially serious consequences, it is critical for PD patients to be monitored closely for development of ICDs as part of routine clinical care.
Breaking Down COVID-19: A living textbook (2020)

The world is amidst a pandemic that is presenting one of the greatest public health challenges of the twenty-first century. A new coronavirus has jumped the interspecies barrier, and it possesses the capability of efficient person-to-person transmission and selectively kills older people and those with underlying chronic conditions. Since its emergence the new coronavirus has resulted in 43.7 million infections and over 1 million deaths as of October 25, 2020—20% of deaths are in the United States followed by Brazil (14%), India (10%), Mexico (7.8%), and the United Kingdom (4%).
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept (2018)

Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. A more comprehensive view of age-related inflammation, that has a scope beyond the conventional view, is therefore required. In this review, we discuss newly emerging data on multi-phase inflammatory networks and proinflammatory pathways as they relate to aging. We describe the age-related upregulation of nuclear factor (NF)-κB signaling, cytokines/chemokines, endoplasmic reticulum (ER) stress, inflammasome, and lipid accumulation. The later sections of this review present our expanded view of age-related senescent inflammation, a process we term "senoinflammation", that we propose here as a novel concept. As described in the discussion, senoinflammation provides a schema highlighting the important and ever-increasing roles of proinflammatory senescence-associated secretome, inflammasome, ER stress, TLRs, and microRNAs, which support the senoinflammation concept. It is hoped that this new concept of senoinflammation opens wider and deeper avenues for basic inflammation research and provides new insights into the anti-inflammatory therapeutic strategies targeting the multiple proinflammatory pathways and mediators and mediators that underlie the pathophysiological aging process.