gebhart/patrepeval huggingface dataset:
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Assay for Simultaneous Measurement of Salivary Testosterone and Cortisol in Healthy Men for Utilization in the Diagnosis of Late-onset Hypogonadism in Males (2009)

It is well known that late-onset hypogonadism in males can cause a variety of symptoms, and the differential diagnosis is relatively difficult, including psychological disorders, stress, and mood disturbances. The level of serum cortisol can be measured to reflect a patient's level of stress. Salivary hormones facilitate the evaluation of physiological hormonal actions based on free hormone assay. For the simultaneous measurement of testosterone and cortisol levels in saliva, we validate a sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay. Concerning accuracy and precision, the lower limit of quantification of salivary testosterone and cortisol were established as 5 and 10 pg/mL, respectively. Testosterone and cortisol in saliva is stable for 2 days, 14 days, and 28 days at room temperature, refrigeration and frozen, respectively. Freezing and thawing for 3 cycles and stimulation of salivation with gum chewing do not alter the measured values of testosterone and cortisol. Total, bioavailable, and free serum testosterone showed slight diurnal changes, but total and bioavailable serum cortisol showed marked diurnal changes. Salivary testosterone levels negatively correlate with age, regardless of the time of saliva collection (r=0.64, p<0.05). However, there is no relationship between salivary cortisol and age (r=0033, p>0.05). LC-MS/MS allows rapid, simultaneous, sensitive, and accurate quantification of testosterone and cortisol in saliva for the diagnosis late-onset hypogonadism or other hormone related disease.
Brachial-Ankle Pulse Wave Velocity as a Marker of Atherosclerotic Vascular Damage and Cardiovascular Risk (2003)

The measurement of brachial-ankle pulse wave velocity (baPWV) is simple and applicable for general population studies. The present study was conducted to evaluate the applicability of baPWV for screening cardiovascular risk as well as for use as a marker of the severity of atherosclerotic vascular damage in a general population. baPWV was measured in a cross-sectional study involving two cohorts constituting a total of 10,828 subjects who underwent annual health screening check up examinations (6,716 males and 4,112 females; age 30 to 74 years). The Framingham risk score and Pocock's score were obtained. Multivariate analysis demonstrated that baPWV was associated with both scores, independently from conventional atherosclerotic risk factors. The receiver-operator characteristic curve demonstrated that a baPWV of 14.0 m/s is useful for risk stratification by Framingham score and to discriminate patients with either stroke or coronary heart disease (n=143), but the likelihood ratios were less than 5.0. Logistic regression analysis demonstrated that a baPWV>14.0 m/s is an independent variable for the risk stratification by Framingham score and for the discrimination of patients with atherosclerotic cardiovascular disease. Thus, baPWV has potential as a new marker of cardiovascular risk and may be more useful than other conventional markers; in addition, baPWV is easy to obtain and serves as an indicator of either atherosclerotic cardiovascular risk or severity of atherosclerotic vascular damage; thus it is useful to screen the general population. While the discriminating powers are not sufficiently high, a cutoff value of 14.0 m/s serves to screen subjects, especially in middle-aged ones, of either gender.
Clinical Trials Probe New Therapies for Some Difficult-to-Treat Cancers (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fehlertheorie (2011)

Die numerische Mathematik löst mathematische Probleme durch die Anwendung von Rechenverfahren (Algorithmen) auf Daten. Dabei entsteht eine vorgegebene Menge von Zahlenwerten als Ergebnis. Die Daten können – z.B. auf Grund von Messungen – fehlerhaft sein, und die Ergebnisse der Rechenoperationen werden durch die endliche Stellenzahl bei der Rechnung ebenfalls verfälscht. Deshalb ist es eine wichtige Aufgabe der Numerik, neben den Methoden, mit denen ein mathematisches Problem numerisch gelöst werden kann, auch die Entstehung von Fehlern bei der konkreten Berechnung von Ergebnissen zu untersuchen.
Project Gustav (2010)

Project Gustav is a digital painting system that enables artists to become immersed in the digital painting experience. It achieves interactivity and realism by leveraging the GPU to implement our novel art media modeling and brush simulation algorithms.
Evidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from N<sup>α</sup>-Tosyl-L-lysine<sup>*</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence for an Active-Center Histidine in Trypsin through Use of a Specific Reagent, 1-Chloro-3-tosylamido-7-amino-2-heptanone, the Chloromethyl Ketone Derived from Nα-Tosyl-L-lysine*Elliott Shaw, Marcos Mares-Guia, and William CohenCite this: Biochemistry 1965, 4, 10, 2219–2224Publication Date (Print):October 1, 1965Publication History Published online1 May 2002Published inissue 1 October 1965https://pubs.acs.org/doi/10.1021/bi00886a039https://doi.org/10.1021/bi00886a039research-articleACS PublicationsRequest reuse permissionsArticle Views665Altmetric-Citations440LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A study on the technical consideration in initial game software planning of online game (2003)

Game software planning is divided into initial game software planning and detailed game software planning. Technique, design, marketing should be considered in initial game software planning. Especially, technical considerations, platform and game engine and sewer construction and sewer architecture should have effect on development cost and time. So, game software designer should choose technical consideration which is suitable for purpose of game software planning. In this paper, we researched technical considerations in initial game software planning, focusing on platform, game engine, game service, network infrastructure.
<i>In vitro</i> and <i>In vivo</i> Analysis of a Rat Bipotential O – 2A Progenitor Cell Line Containing the Temperature‐sensitive Mutant Gene of the SV40 Large T Antigen (1993)

Primary cultures from neonatal optic nerve contain pluripotential O-2A progenitor cells that are capable of differentiating into oligodendrocytes, type-2 astrocytes or adult O-2A progenitors (O-2Aadult). Since primary optic nerve cultures contain a mixture of glial cell types of which only a small number are O-2A progenitors, experiments on cell lineage and differentiation carried out using these cultures are both intrinsically limited and difficult to interpret. Ideally, cells from a clonal cell population would provide the optimal starting material for biological studies. In this paper we describe the creation of an O-2A progenitor cell line using a retrovirus carrying a temperature-sensitive mutant SV40 large T antigen gene. This cell line has provided sufficient numbers of cells to allow analysis of their in vitro properties and their behaviour following transplantation into an in vivo environment. At the non-permissive temperature (39 degrees C), these cells differentiate into oligodendrocytes and type-2 astrocytes in a similar fashion to O-2A progenitor cells from primary cultures (O-2Aprim). When grown in media containing platelet-derived growth factor and basic fibroblast growth factor, the cell numbers can be expanded in culture without differentiating, consistent with the behaviour of O-2Aprim progenitor cells. By exploiting this property, it has been possible to culture large numbers of O-2A progenitors for in vivo analysis. In this study we have shown that transplantation of this O-2A cell line into glia-free areas in adult rat spinal cord results in differentiation of a proportion of cells into oligodendrocytes which are capable of myelinating axons. Furthermore, differentiation of O-2A cells into astrocytes was also observed, indicating that the bipotentiality of these cells in vitro can also be demonstrated in vivo.
Underground cable fault location: a handbook to TD-153. Final report (1977)

A handbook, designed to serve as a reference document to guide utility operations personnel in the selection and use of fault location equipment on underground power cables, is described. The principal emphasis is directed toward distribution cables but transmission cables are also considered in pertinent instances. The contents are organized into three chapters and an appendix: Ch. 1 provides a set of pertinent definitions for terms that are used throughout the text. Ch. II is intended for general reference. It identifies and describes seven generic types of fault location equipment. Ch. III presents an approach for the selection of a specific fault locator. Two selection procedures are presented. The first procedure treats the initial equipment purchase. The second procedure treats the selection of the equipment best suited to a particular fault. App. A presents a summary of the available fault location equipment including available specifications.
Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study (2020)

Mogamulizumab in combination with durvalumab or tremelimumab did not result in potent antitumor efficacy in patients with advanced solid tumors. Tolerability of mogamulizumab 1 mg/kg combined with durvalumab or tremelimumab 10 mg/kg was acceptable.
Hemorrhagic Shock in Rats (1969)

This study was undertaken in an attempt to establish a method of bleeding rats and autotransfusing the blood removed from them which would be associated with a mortality of near 50%. The use of different combinations of fluids as therapy for hemorrhage in the rat could be assessed optimally, since the likelihood of a given method of treatment being both better or worse than autotransfusing all the blood removed can best be determined when the latter is associated with a mortality of 50%. A previous study from this laboratory reported a hemorrhagic shock model in the rat which was based upon bleeding to a mean blood pressure of 30 mm Hg for 60 minutes.<sup>1</sup>This model was associated with a mortality of only 24% among rats surviving to be treated by returning all the blood removed from them. When the duration of hypotension was lengthened more rats died before
Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors (2009)

This chapter contains sections titled: The Tetanus and Botulinum Neurotoxins Inhibitors of BoNT and TeNT Zinc Proteases Anthrax Toxin Lethal Factor Anthrax Toxin Lethal Factor Inhibitors Conclusion References
Molecular interactions in mixtures of carboxylic acids with amines. 2. Volumetric, conductimetric, and NMR properties (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular interactions in mixtures of carboxylic acids with amines. 2. Volumetric, conductimetric, and NMR propertiesFriedrich Kohler, Ram Gopal, G. Goetze, H. Atrops, M. A. Demeriz, E. Liebermann, Emmerich Wilhelm, F. Ratkovics, and B. PalagyiCite this: J. Phys. Chem. 1981, 85, 17, 2524–2529Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://pubs.acs.org/doi/10.1021/j150617a022https://doi.org/10.1021/j150617a022research-articleACS PublicationsRequest reuse permissionsArticle Views421Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
AndroMedia : Towards a Context-aware Mobile Music Recommender (2008)

Portable music players have made it possible to listen to a personal collection of music in almost every situation, and they are often used during some activity to provide a stimulating audio environment. Studies have demonstrated the effects of music on the human body and mind, indicating that selecting music according to situation can, besides making the situation more enjoyable, also make humans perform better. For example, music can boost performance during physical exercises, alleviate stress and positively affect learning. \n\n We believe that people intuitively select different types of music for different situations. Based on this hypothesis, we propose a portable music player, AndroMedia, designed to provide personalised music recommendations using the user's current context and listening habits together with other user's situational listening patterns. We have developed a prototype that consists of a central server and a PDA client. The client uses Bluetooth sensors to acquire context information and logs user interaction to infer implicit user feedback. The user interface also allows the user to give explicit feedback. Large user interface elements facilitate touch-based usage in busy environments. The prototype provides the necessary framework for using the collected information together with other user's listening history in a context- enhanced collaborative filtering algorithm to generate context-sensitive recommendations. The current implementation is limited to using traditional collaborative filtering algorithms. \n\n We outline the techniques required to create context-aware recommendations and present a survey on mobile context-aware music recommenders found in literature. As opposed to the explored systems, AndroMedia utilises other users' listening habits when suggesting tunes, and does not require any laborious set up processes.
Bacteria reactive to plaque‐toxin‐neutralizing monoclonal antibodies are related to the severity of gingivitis at the sampled site (1993)

Certain monoclonal antibodies (Mabs) neutralize the inhibition of HL60 cell growth by bacterial plaque extracts. The aim of this study was to enumerate and identify the bacteria reactive to these Mabs at sites where periodontal disease was measured by gingival index, pocket depth and attachment loss. The bacterial colonies were grown on blood agar and the colonies counted directly and after immunoblotting. Sites that bled on probing (n = 15) had a mean of 3.35% Mab-positive colonies (SEM = 0.52%) and sites that did not bleed (n = 9) had a mean of 1.61% (SEM = 0.41%). The percentage of Mab-positive colonies also correlated with gingival index but not with the total number of colonies sampled, attachment loss or pocket depth. Antigen was expressed by 4 genera: strains of Streptococcus sanguis and/or Eikenella corrodens (8 sites), Staphylococcus epidermidis (4 sites) and Corynebacterium minutissimus (1 site). The results suggest that the antigens detected on these bacteria by the Mabs may be processed to form toxins and maintain gingivitis by irritating the surrounding cells.
English Archaisms in Pennsylvania German (1953)

Research Article| April 01 1953 English Archaisms in Pennsylvania German Carroll E. Reed Carroll E. Reed University of Washington Search for other works by this author on: This Site Google Publication of the American Dialect Society (1953) 19 (1): 3–7. https://doi.org/10.1215/-19-1-3 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Carroll E. Reed; English Archaisms in Pennsylvania German. Publication of the American Dialect Society 1 April 1953; 19 (1): 3–7. doi: https://doi.org/10.1215/-19-1-3 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsAmerican Dialect SocietyThe Publication of the American Dialect Society Search Advanced Search The text of this article is only available as a PDF. American Dialect Society1953 Article PDF first page preview Close Modal You do not currently have access to this content.
Asymmetric reduction of aromatic ketones with reagents prepared from sodium borohydride and various carboxylic acids in the presence of 1,2:5,6-di-O-isopropylidene-α-<scp>D</scp>-glucofuranose (1981)

Asymmetric reduction of aromatic ketones with the reagents prepared from sodium borohydride and carboxylic acids in the presence of 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose at 0 °C gives (R)-alcohols with enantiomeric excesses as high as 83%. The optimum conditions for producing maximum selectivity and maximum yield of reaction products from sodium borohydride and isobutyric acid have been examined.
Vibrational spectra of germane and silane derivatives. Part I. The fundamental vibration frequencies of dichlorogermane (1969)

The gas-phase i.r. and liquid-phase Raman spectra of GeH2Cl2 and GeD2Cl2 have been recorded. A normal coordinate treatment has lead to the positive identification of all the fundamental frequencies. The calculations based on the C2v model were initially carried out on SiH2Cl2 where a comparison with previous results was possible.
CD133+adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF) (2009)

These data support the evidence that CD133 expression characterises a population of cells within the resident adult human retina which have progenitor cell properties and that their turnover and differentiation is influenced by LIF. This may explain differences in retinal responses observed following disease or injury.
Influence of hypocaloric diet on alpha-adrenergic responsiveness of obese human subcutaneous adipocytes. (1981)

Spontaneous and stimulated lipolytic activity of subcutaneous abdominal adipocytes from obese subjects treated by a hypocaloric diet (800-1000 kcal/d) for 13-15 d were studied. A strong increase in basal lipolytic activity of the adipocytes occurred after the restrictive diet treatment. Linked to this phenomenon, an important alpha-adrenergic antilipolytic effect of adrenaline appeared whereas, the beta-stimulating effect of isoproterenol (beta-adrenomimetic drug) was not affected. The increased alpha-inhibitory effect of adrenaline was shown to theophylline-stimulated adipocytes of energy-restricted subjects. It is concluded that after a period of hypocaloric diet, the adrenaline-dependent lipolysis of subcutaneous abdominal fat cells of obese subjects is reversed. The lipolytic response induced by adrenaline, described in the adipocytes of obese controls, develop towards an alpha-adrenergic antilipolytic response after the hypocaloric treatment. Our data suggest that, in states with increased rate of lipolysis, there is an increased readiness for alpha-adrenergic response.
Robust parsing using a hidden Markov model (1998)

Recent approaches to statistical parsing include those that estimate an approximation of a stochastic, lexicalized grammar directly from a treebank and others that rebuild trees with a number of tree-constructing operators, which are applied in order according to a stochastic model when parsing a sentence. In this paper we take an entirely different approach to statistical parsing, as we propose a method for parsing using a Hidden Markov Model. We describe the stochastic model and the tree construction procedure, and we report results on the Wall Street Journal Corpus.
A semi‐automatic method for peak and valley detection in free‐breathing respiratory waveforms (2006)

The existing commercial software often inadequately determines respiratory peaks for patients in respiration correlated computed tomography. A semi-automatic method was developed for peak and valley detection in free-breathing respiratory waveforms. First the waveform is separated into breath cycles by identifying intercepts of a moving average curve with the inspiration and expiration branches of the waveform. Peaks and valleys were then defined, respectively, as the maximum and minimum between pairs of alternating inspiration and expiration intercepts. Finally, automatic corrections and manual user interventions were employed. On average for each of the 20 patients, 99% of 307 peaks and valleys were automatically detected in 2.8 s. This method was robust for bellows waveforms with large variations.