gebhart/patrepeval huggingface dataset:
Hypoglycemic Effect of the Rhizomes of Smilax glabra in Normal and Diabetic Mice. (1997)

The hypoglycemic effect of the rhizomes of Smilax glabra ROXBURGH (Liliaceae) was investigated in normal and KK-Ay mice, one of the animal models of non-insulin dependent diabetes mellitus (NIDDM) with hyperinsulinemia. The methanol extract of rhizomes of Smilax glabra ROXBURGH (SM, 100 mg/kg body weight) reduced the blood glucose of normal mice 4 h after intraperitoneal administration (p<0.05), and also significantly lowered the blood glucose of KK-Ay mice under similar conditions (p<0.001). However, SM did not affect the blood glucose in streptozotocin-induced diabetic mice, one of the animal models of insulin-dependent diabetes mellitus (IDDM) with hypoinsulinemia. SM also suppressed epinephrine-induced hyperglycemia in mice. SM-treated KK-Ay mice significantly decreased the blood glucose in an insulin tolerance test. We concluded that the hypoglycemic effect of SM raised insulin sensitivity.
Radioimmunoassay of a human serum growth factor for Balb/c-3T3 cells: derivation from platelets. (1977)

A radioimmunoassay has been developed for the detection and quantification of a human serum polypeptide that has growth-promoting activity for confluent Balb/c-3T3 cells. Antiserum to this growth factor does not recognize antigens in mouse, guinea pig, or bovine serum but does detect some crossreacting antigen in the serum of the New World monkey Cebus albifrons and more in the serum of the Old World rhesus monkeys Macaca mulatta and M. fascicularis, demonstrating that the antigenic determinants of the growth factor have a degree of species specificity. Serum derived from whole human blood contains approximately 770 pg of the growth factor per mg of protein; serum derived from platelet-poor blood contains about 112 pg of the growth factor per mg of protein. As much as 1 microng of the growth factor per mg of protein has been recovered from human platelets by heating them at 100 degrees for 2 min. Approximately 1-2 ng of the growth factor, in either whole serum or platelets, stimulates 5 to 10 X 10(3) confluent Balb/c-3T3 cells to replicate. The heat treatment of platelets allows the purification and quantitative recovery of the growth factor from blood.
Business language analysis for object-oriented information systems (1996)

Business language analysis grows out of a philosophy that treats business organizations as living systems. A key concern is the meaning of business information that provides adaptive survival advantage and strategic leverage. Popular object-oriented methodologies correctly recognize the need to identify business objects by analyzing the problem domain. The approach described in this paper fills in the details that are implied, but not specified by other methods. It builds a business language model that clarifies both the content and structure of the terminology actually used in the business. Simple examples of business language analyses are given. Deeper insight is offered in a discussion of lexical semantic and category theory and in the proposed notion of business language patterns.
ENHANCING HEAT TRANSFER RATES BY INDUCING LIQUID-LIQUID PHASE SEPARATION: APPLICATIONS AND MODELING (2015)

This paper focuses on heat transfer enhancement during spinodal decomposition, and it provides an updated review as well as a discussion of future developments. The analysis is mainly based on the work of two research groups at Tel-Aviv University (Israel) and at University of Brescia (Italy). We review the theory of spinodal decomposition of liquid−liquid binary mixtures and we discuss the diffuse interface (DI) approach. While mass and momentum equations in the DI approach have been developed and discussed in other works, we also look into the energy equation, which has been only recently investigated. Direct visualizations of both static and flowing mixture during decomposition are provided. Visualizations of the decomposition in a quiescent fluid have been previously reported, while flowing conditions have been analyzed only recently. Interestingly enough, the morphology is rather different during flowing conditions, where the decomposition exhibits a nucleationlike morphology and not the typical bicontinuous structure observed during spinodal decomposition of a quiescent fluid. Enhancement of heat transfer performances is shown in channels (sizes of 0.8 and 2 mm) using an upper critical solution temperature (UCST) mixture. Although different conditions are analyzed, the results show a consistent enhancement of the heat transfer. The paper reports also some new experimental work on the heat transfer for a lower critical solution temperature (LCST) mixture that can be actually used in cooling applications. A coarse-grained model that could be potentially used for the sizing of large-scale equipment is discussed in term of a possible future development that needs to be further investigated and validated.
A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum (2020)

Extracellular vesicles (EVs) are nano-sized vesicles containing nucleic acid and protein cargo that are released from a multitude of cell types and have gained significant interest as potential diagnostic biomarkers. Human serum is a rich source of readily accessible EVs; however, the separation of EVs from serum proteins and non-EV lipid particles represents a considerable challenge. In this study, we compared the most commonly used isolation techniques, either alone or in combination, for the isolation of EVs from 200 µl of human serum and their separation from non-EV protein and lipid particles present in serum. The size and yield of particles isolated by each method was determined by nanoparticle tracking analysis, with the variation in particle size distribution being used to determine the relative impact of lipoproteins and protein aggregates on the isolated EV population. Purification of EVs from soluble protein was determined by calculating the ratio of EV particle count to protein concentration. Finally, lipoprotein particles co-isolated with EVs was determined by Western blot analysis of lipoprotein markers APOB and APOE. Overall, this study reveals that the choice of EV isolation procedure significantly impacts EV yield from human serum, together with the presence of lipoprotein and protein contaminants.
Structure-Property Relationships of Naphthalene Diimide Based Organic Electrodes (2013)

Abstract not Available.
Levels of three inflammation markers, C-reactive protein, serum amyloid A protein and procalcitonin, in the serum and cerebrospinal fluid of patients with meningitis (2001)

The levels of C-reactive protein (CRP) and serum amyloid A protein (SAA) in blood are increased in patients with inflammatory diseases as acute phase proteins. Most of the presently used indicators of inflammation, such as body temperature, white cell count, erythrocyte sedimentation rate or CRP, are non-specific parameters. In contrast, procalcitonin (PCT) has been reported to be selectively induced by severe bacterial infection during the systemic inflammatory response syndrome (SIRS), and also in sepsis or multiorgan dysfunction syndrome. PCT expression is only slightly induced, if at all, by viral infections, autoimmune disorders, neoplastic diseases and trauma of surgical intervention. We measured the concentrations of CRP, SAA and PCT in the sera and cerebrospinal fluid (CSF) of 30 patients with bacterial, viral, or mycotic meningitis, and 12 patients with a noninflammatory central nervous system disease as controls. An extremely high CRP level in CSF of above 100 microg/L was seen in all seven bacterial meningitis patients and in only 10% of the viral meningitis patients. A high SAA level in CSF of greater than 10 microg/L was observed in all of the bacterial meningitis and mycotic meningitis patients, and in 95% of the viral meningitis patients. Among those with bacterial meningitis, the serum PCT level was more elevated in those with more serious bacterial meningitis. The PCT level in the CSF did not significantly differ among the patients with the three types of meningitis. However, the serum PCT level was very high above 0.1 microg/L in all seven bacterial meningitis patients, especially in the clinically serious cases.
p<i>K</i><sub>a</sub>-Directed Incorporation of Phosphonates into MOF-808 via Ligand Exchange: Stability and Adsorption Properties for Uranium (2019)

We report a class of p<i>K</i><sub>a</sub>-directed, precise incorporation of phosphonate ligands into a zirconium-based metal-organic framework (Zr-MOF), MOF-808, via ligand exchange. By replacing of formate ligands with methylphosphonic acid (MPA), ethanephosphonic acid (EPA), and vinylphosphonic acid (VPA), whose p<i>K</i><sub>a</sub> values are slightly higher than that of the benzenetricarboxylic acid (BTC) linker in MOF-808, daughter MOFs can be synthesized without controlling the stoichiometric amounts of added MPA. The methylphosphonate MOFs (808-MPAs) demonstrate high porosities, with only small changes in the pore diameter and specific surface area when compared with the parent MOF-808. PXRD patterns and structure refinements indicate the expansion of the lattice for all MOFs after decorating with methylphosphonate ligands. The XPS spectra reveal a charge redistribution of the Zr<sub>6</sub> node after ligand exchange. FTIR and <sup>31</sup>P MAS NMR spectra, combined with DFT calculation, suggest that the methylphosphonate ligand is connected to the Zr<sub>6</sub> node as CH<sub>3</sub>P(O)(OZr)(OH) species with an accessible acidic P-OH group. Besides, 808-MPAs demonstrate excellent chemical stability in concentrated HCl, concentrated HNO<sub>3</sub>, hot water, and 0.2 mol/L trifluoroacetic acid solutions. Impressively, 808-MPAs show ultrafast adsorption performance for uranyl ions using the ion-exchange property of P-OH sites in their cavity environment, with an equilibrium time of 10 min, much quicker than the previous adsorbents. The present study demonstrates a series of important proof-of-concept examples of the p<i>K</i><sub>a</sub>-directed Zr-MOFs with tunable phosphonate-terminated ligands, which can extend to other phosphonate-functionalized Zr-based framework platforms in the near future.
Clinical application of continent anal plug in bedridden patients with intractable diarrhea (2001)

The continent anal plug is an efficient method of treating patients with loss of bowel control and incontinence because it enables controlled fecal evacuation and helps reduce skin complications without causing anorectal mucosal injury.
Enhanced Efficiency of Mapping Distribution Protocols in Scalable Routing and Addressing Architectures (2010)

In this paper, we present a discussion of some architectural principles pertaining to mapping distribution protocols that are common components of proposed designs to improve the scalability of future Internet routing tables. The efficiency of a mapping distribution protocol in terms of response time and the volume of traffic load it generates are important considerations. We consider how Egress Tunnel Routers (ETRs) can perform aggregation of end-point ID (EID) address space belonging to their downstream delivery networks, in spite of migration/re-homing of some subprefixes to other ETRs. This aggregation may be useful for reducing the processing load and memory consumption associated with mapping messages, especially in resource-constrained components of the mapping distribution system. Consequently, the proposed methods can also help improve response time (e.g., first packet delay). Some key architectural issues, their potential solutions and trade-offs are discussed. The overarching goal is to expose and discuss some subtleties in design considerations for mapping distribution and management.
A Performance-Oriented Circuit Partitioning Algorithm with Logic-Block Replication for Multi-FPGA Systems (1997)

In this paper, we extend the circuit partitioning algorithm which we had proposed for multi-EPGA systems and present a new algorithm in which the delay of each critical signal path is within a specified upper bound imposed on it. The core of the presented algorithm is recursive bipartitioning of a circuit. The bipartitioning procedure consists of three stages: (0) detection of critical paths; (1) bipartitioning of a set of primary inputs and outputs; and (2) bipartitioning of a set of logic-blocks. In (0), the algorithm computes the lower bounds of delays for paths with path delay constraints and detects the critical paths based on the difference between the lower and upper bounds dynamically in every bipartitioning procedure. The delays of the critical paths are reduced with higher priority. In (1), the algorithm attempts to assign the primary inputs and outputs on each critical path to one chip so that the critical path does not cross between chips. Finally in (2), the algorithm not only decreases the number of crossings between chips but also assigns the logic-blocks on each critical path to one chip by exploiting a network flow technique. The algorithm has been implemented and applied to MCNC PARTITIONING 93 benchmark circuits. The experimental results demonstrate that it resolves almost all path delay constraints while maintaining the maximum number of required I/O blocks per chip small compared with conventional algorithms.
Long‐term deficits in health‐related quality of life after recovery from thrombotic thrombocytopenic purpura (2008)

After recovery from TTP, patients may have persistent cognitive and physical difficulties.
Characteristics and Immunobiology of Grass Pollen Allergens (2003)

Grass pollens are one of the most important airborne allergen sources worldwide. About 20 species from five subfamilies are considered to be the most frequent causes of grass pollen allergy, and the allergenic relationships among them closely follow their phylogenetic relationships. The allergic immune response to pollen of several grass species has been studied extensively over more than three decades. Eleven groups of allergens have been identified and described, in most cases from more than one species. The allergens range from 6 to 60 kD in apparent molecular weight and display a variety of physicochemical properties and structures. The most complete set of allergens has so far been isolated and cloned from Phleum pratense (timothy grass) pollen. Based on the prevalence of IgE antibody recognition among grass pollen-sensitized individuals, several allergens qualify as major, but members of two groups, groups 1 and 5, have been shown to dominate the immune response to grass pollen extract. Isoform variation has been detected in members of several of the allergen groups, which in some cases can be linked to observed genetic differences. N-linked glycosylation occurs in members of at least three groups. Carbohydrate- reactive IgE antibodies have been attributed to grass pollen sensitization and found to cross-react with glycan structures from other allergen sources, particularly vegetable foods. Another cause of extensive cross-reactivity are the group 12 allergens (profilins), which belong to a family of proteins highly conserved throughout the plant kingdom and present in all tissues. Members of eight allergen groups have been cloned and expressed as recombinant proteins capable of specific IgE binding. This development now allows diagnostic dissection of the immune response to grass pollen with potential benefits for specific immunotherapy.
<title>Detection of skin line in computed radiographs for improved tone scale</title> (1997)

An algorithm for the detection of the skin-line transitions in computed radiographic imagery is presented. Knowledge of the gray-level values associated with the skin-line transition can be utilized by a tone-scaling algorithm to prevent the loss of visibility of the skin line. Features associated with the line profile of the significant transitions are used to identify the kin-line transition in digital radiographs. A Gaussian maximum likelihood classifier is used to separate the skin-line transitions from those associated with the background-foreground, background-hardware, and other significant transitions. Results are presented for a set of operational computed radiography exams.
Bovine haptoglobin response in clinically defined field conditions (1991)

In order to assess the usefulness of haptoglobin as a measure of the acute phase response in cattle, the concentration of serum haptoglobin was estimated in the non-infectious conditions of milk fever and ketosis, and in the infectious conditions of severe mastitis, acute severe metritis, retained placenta and chronic endometritis. Mean haptoglobin concentrations were normal in cattle with non-infectious conditions and chronic endometritis but significantly increased in cattle with infectious conditions.
Effects of Head and Neck Inclination on Bilateral Sternocleidomastoid EMG Activity in Healthy Subjects and in Patients with Myogenic Cranio-Cervical-Mandibular Dysfunction (2000)

This study was conducted in order to determine the effect of head and neck position on bilateral electromyographic (EMG) activity of the sternocleidomastoid muscles. The study was performed on 16 patients with myogenic cranio-cervical-mandibular dysfunction (CMD) and 16 healthy subjects. EMG recordings at rest and during swallowing of saliva and maximal voluntary clenching were performed by placing surface electrodes on the right and left sternocleidomastoid muscles. EMG activity was recorded in the left lateral decubitus position, in a darkened room and with the individual's eyes closed, under the following experimental conditions: 1. Head, neck, and body horizontally aligned; 2. Head and neck upwardly inclined with respect to the body, simulating the effect of a thick pillow, 3. Head and neck downwardly inclined with respect to the body, simulating the effect of a thin pillow. Variation of head and neck positions was determined by measuring the distance from the angle of neck and shoulder and the apex of the shoulder (SND = shoulder-neck distance) of each individual. Then, head and neck were forward or downwardly inclined with respect to the body at one-third of SND. A significantly higher contralateral EMG activity and a more asymmetric EMG activity were observed in the CMD group than in the healthy subjects (Kruskal-Wallis Test). These results suggest a different behavior of bilateral sternocleidomastoid EMG activity in CMD patients than in healthy subjects depending on the positioning of the head and neck.
Remote Electrochemical Sensor for Trace Metal Contaminants (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRemote Electrochemical Sensor for Trace Metal ContaminantsJoseph. Wang, David. Larson, Nancy. Foster, Saulius. Armalis, Jianmin. Lu, Xu. Rongrong, Khris. Olsen, and Alberto. ZirinoCite this: Anal. Chem. 1995, 67, 8, 1481–1485Publication Date (Print):April 15, 1995Publication History Published online1 May 2002Published inissue 15 April 1995https://pubs.acs.org/doi/10.1021/ac00104a029https://doi.org/10.1021/ac00104a029research-articleACS PublicationsRequest reuse permissionsArticle Views523Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RNA self-cleavage activated by ultraviolet light-induced oxidation (2011)

A novel UV-C-light-induced ribozyme activity was discovered within the highly structured 5'-genomic regions of both Hepatitis C Virus (HCV) and the related Classic Swine Fever Virus (CSFV). Cleavage is mediated by exposure to UV-C light but not by exogenous oxygen radicals. It is also very selective, occurring at base positions HCV C(79) and CSFV A(45) in some molecules and at the immediately adjacent 5'-positions HCV U(78) and CSFV U(44) in others. Among other reaction products, the majority of biochemically active products detected contained 3'-phosphate and 5'-phosphate-end groups at the newly generated termini, along with a much lower amount of 3'-hydroxyl end group. While preservation of an E-loop RNA structure in the vicinity of the cleavage site was a requisite for HCV RNA self-cleavage, this was not the case for CSFV RNA. The short size of the reactive domains (~33 nt), which are compatible with primitive RNA motifs, and the lack of sequence homology, indicate that as-yet unidentified UV-activated ribozymes are likely to be found throughout structured RNAs, thereby providing clues to whether early RNA self-cleavage events were mediated by photosensitive RNA structures.
274. The deposition of carbon on vitreous silica (1948)

R. Iley and H. L. Riley, J. Chem. Soc., 1948, 1362 DOI: 10.1039/JR9480001362
In Situ Hybridization for Detection of <scp>HIV</scp><scp>RNA</scp> (1993)

In HIV studies, in situ hybridization can be used for identifying virion RNA, mRNA being produced for virion packaging, and proviral DNA in the cytoplasm or integrated in the nucleus. This unit focuses primarily on identifying virion RNA, because this is the most sensitive means by which in situ hybridization can be employed to detect HIV expression. In situ hybridization, as developed for HIV RNA detection, involves several protocols: (1) preparation of a radioactive or nonradioactive RNA probe; (2) in situ hybridization of probe to cells and paraffin sections of tissue; (3) detection of radiolabeled probe by emulsion autoradiography; (4) development, staining, and mounting of slides; and finally (5) examination of slides by bright-field, dark-field, specular reflectance, or laser-scanning confocal microscopy. The protocols presented in this unit describe a setup involving up to 150 slides.