gebhart/patrepeval huggingface dataset:
Carbon-13-labeled benzo[a]pyrene and derivatives. 1. Efficient pathways to labeling the 4, 5, 11, and 12 positions (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13-labeled benzo[a]pyrene and derivatives. 1. Efficient pathways to labeling the 4, 5, 11, and 12 positionsRichard S. Bodine, Mark Hylarides, Guido H. Daub, and David L. VanderJagtCite this: J. Org. Chem. 1978, 43, 21, 4025–4028Publication Date (Print):October 1, 1978Publication History Published online1 May 2002Published inissue 1 October 1978https://pubs.acs.org/doi/10.1021/jo00415a008https://doi.org/10.1021/jo00415a008research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 683: Regression of Plaque Volume in One Arterial Bed is not Necessarily Associated with Similar Changes in Other Vessels (2008)

Background: Population-based studies have shown good correlation between severity of atherosclerotic disease in one arterial bed and involvement of other vessels. However, in patients with coronary artery disease (CAD), it remains unclear whether atherosclerotic plaque in an artery might regress or progress in parallel with other vessels. Accordingly, the present study was performed in patients with CAD to compare changes in plaque volume (PV) between the left main (LMT) and right coronary arteries (RCA), thoracic descending aorta (TDA) and common carotid artery (CCA), and to clarify clinical factors and biomarkers which might affect changes in PV in each artery. Methods: Using 64-multislice computed tomography, PVs in each artery were determined before and after 2.0-year follow-up period in 52 patients with CAD (67.4±9.9yo). Based on our previous study using ultrasound, CCA-PV was determined at windows of 90–240HU and TDA-PV determined manually. Coronary soft plaque was determined at windows of 0–75HU. Plasma levels of hsCRP, matrix metalloproteinase (MMP)-9 and urinary 8-iso-prostaglandin F2 α (PGF) were determined at baseline. Results: At baseline, PVs of TDA were correlated with CCA-PV (r=0.38, p<0.02), but PVs of other arteries did not correlate to each other. Two-year later, PVs of LMT, RCA, TDA, and CCA were reduced in 41, 62, 27, and 39% of patients, respectively. Changes in LMT-PV were weakly related with those of TDA-PV (r=0.37, p=0.02) and RCA-PV (r=0.31, p=0.08), but there were no relation between other arteries. The multivariate analysis revealed that treatment with statin and low LDL-cholesterol (C, <100mg/dl) were independent variables regarding a reduction in DTA-PV, but, in LMT, only low LDL-C was independent variable. However, there were no independent variables in RCA or CCA. The ratio of soft PV to total PV was similar between LMT (45.2±7.1%) and RCA (45.7±4.9%) at baseline and was unchanged in the follow-up study. None of hsCRP, MMP-9 or PGF levels was related with PVs of any arteries at baseline and with changes in PVs. Conclusions: Regression of PV in one arterial bed dose not necessarily allow us to predict atherosclerotic changes in the other vessels. Major factors which affect changes in PV may not be homogeneous between arteries.
Young Research Forum: Young Scientist Awards Asia Bio 2020 (2019)

We cordially invite you to “16th International Conference and Exhibition on Nanomedicine & Pharmaceutical Nanotechnology” (NanoPharma 2020) scheduled during May 04-05, 2020 at Amsterdam, Netherlands with theme: Challenges and Innovations in Nanomedicine and Pharmaceutical Nanotechnology. NanoPharma 2020 invites all the recent innovations, trends, and concerns as well as practical challenges encountered and solutions adopted in the fields of Nanotechnology and Nanomedicine.
Regulatory elements of hepatitis B virus transcription (2002)

The precise modulation of hepatitis B virus (HBV) gene expression is essential for replication of the virus. HBV sequences are transcribed under the control of the preC/pregenomic, S1, S2 and X promoters. With the exception of S1, all the HBV promoters lack the orthodox TATA box motifs required for the formation of the transcription initiation complex, and as such they represent a unique model of transcription initiation elements. The presence of two enhancer sequences and negative regulatory elements in the HBV genome further augments the controlled synthesis of HBV- RNA. All these transcription cis-elements are embedded within protein coding regions of the genome. This feature demonstrates the remarkable ability of the virus to maximize the function of its small genome. HBV transcription control elements also display a preference for liver-specific or liver-enriched trans-factors, which contributes to the liver tropism of the virus. This review outlines the major HBV transcription regulatory elements and highlights the reliance of accurate HBV gene modulation on the complex interplay between several trans-acting factors and their corresponding cis- motifs in the viral genome.
Synthesis of Amorphous Hydrophobic Telechelic Hydrocarbon Diols via ADMET Polymerization (2009)

Abstract Amorphous, hydrophobic telechelic hydrocarbon diols were synthesized using acyclic diene metathesis (ADMET) polymerization. These diols can be used in hydrolysis and UV resistant polyurethanes. The hydrocarbon backbone is based on a mimic of an ethylene/isobutylene polymer, made by the ADMET polymerization of a gem‐dimethyl substituted α , ω ‐diene followed by hydrogenation of the polymer's repeat unit unsaturation. Chain termination reactants (CTR's) having one, three, and nine methylene “spacers,” respectively, between their olefin and alcohol precursor group were used to cap the polymer chain ends to yield 2.0 functional telechelics. Use of the medium length CTR in a polymerization–depolymerization scheme, resulted in amorphous ( T g = −56 °C) telechelic diols with good molecular weight control. magnified image
Processing oxidic waste of lead‐acid batteries in order to recover lead (2014)

Abstract The main process parameters have been investigated with a relatively new method for lead recovery from oxidic paste. The method consisting in leaching with NaOH and is also useful for processing other secondary resources (volatile dusts resulted from metallurgical extraction of lead from primary resources). The chemical analysis and X‐ray diffraction have attested that the oxidic paste resulted from the dismantling of spent lead‐acid batteries has a content of 70–73% Pb, mainly as anglesite (around 38% PbSO 4 ) and lanarkite (about 36% Pb 2 SO 5 ). Experiments have been carried out through leaching with NaOH of the industrial paste out of spent car batteries as well as for the pure substances. The experiments were conducted at temperatures of 40, 60 and 80 °C, at various solid/liquid ratios (S : L = 1 : 10; 1 : 30 and 1 : 50) and different molarities for the NaOH solutions (2, 4, 6 and 8 M). The reaction time was 1 h for the leaching of the pure substances and 2 h for the leaching of the industrial pastes. An extraction efficiency of 92% Pb was obtained with a leaching solution of 6 M NaOH, at 60 °C, for 2 h and S/L ratios of 1 : 20–1 : 30. The efficiency may be increased up to 97% Pb only when the leaching process is carried out in two steps. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.
Information technologies and health care. 3. The need for new technologies to support the conveyence and use of knowledge (1970)

The first two communications in this series, published in the January and February issues (<i>Arch Intern Med</i><b>125</b>:157 and 351) concluded that provision of "the best known care to all who need it" is contingent on at least three prerequisites: the supply of physicians, physicians' ability to obtain relevant up-to-date knowledge, and physicians' ability to use this knowledge unerringly in patient care; they suggested that, without new technologies, the shortage of physicians in this country, let alone abroad, will be difficult or impossible to overcome during this century. This third contribution suggests that new technologies are also needed in the acquisition and use of an exponentially-growing body of medical knowledge by practicing physicians, regardless of their number. <h3>The Growth of Medical Knowledge</h3> The total body of knowledge to be mastered by the student and implemented by the practitioner appears to have been quite static in the days of
TAPE TRANSPORT MODELING AND CONTROLLER DESIGN (2004)

A tape transport system consisting of a take-up reel servo, a supply-reel servo, and a capstan servo is proposed. The mathematical model of the system is derived. Two well know controllers – Linear Quadratic Regulator (LQR) and P/PI controller, are designed to regulate the output of the system. An input gain matrix N is calculated and applied to the LQR to eliminate steady-state offset. Simulation is carried out to investigate the step response of the system.
A sheep's song: a writer's reminiscences of Japan and the world (1999)

This critically acclaimed autobiography was an instant bestseller in Japan, where it has gone through more than forty printings since its first publication. Cultural critic, literary historian, novelist, poet, and physician, Kato Shuichi reconstructs his dramatic spiritual and intellectual journey from the militarist era of prewar Japan to the dynamic postwar landscapes of Japan and Europe. This fluid translation of Sheep's Song captures Kato's unique voice and brings his insightful interpretation of modern Japan and its tumultuous relations with the outside world to English-speaking readers for the first time. Kato describes his youthful interest in the natural sciences as well as in Japanese and Western literatures - from the Man'yoshu to Akutagawa Ryunosuke, Baudelaire, Valery, and Proust. Turning to the rise of Japanese fascism in the late 1930s, he recalls his rebellion against the jingoistic political atmosphere of the time. The chapters on the war and its aftermath include experiences of Hiroshima shortly after the bombing and the often tragicomic encounters between the defeated Japanese nation and the American Occupation forces. Throughout, memories of his wide-ranging literary career and broad experiences in Europe as a student, traveler, and cultural observer are punctuated by his unique perspectives on the relation between imagination, art, and politics. A postscript written especially for the English-language edition discusses the Vietnam War, the subsequent transformation of Japan, the cultures and societies of Europe, the United States, and China, and the collapse of the Soviet Union.
Improving power network state estimation using GPS time transfer (2003)

Modern electrical power networks use control techniques in order to ensure the security of the network, where the security of a power network is its ability to withstand failures. Currently, an estimate of the state is computed using the method of least squares on data consisting of network structural data and a sufficient set of bus voltage magnitude and power flow measurements. It is shown that, using GPS (Global Positioning System) time to synchronize measurements, the measurement data set can be augmented with accurate voltage phase measurements. By incorporating accurate phase measurements from buses at major substations in the power network, more accurate state estimates can be computed. More importantly, however, bad measurements can be isolated more easily and removed from the estimation process altogether, yielding an even more accurate state-estimate. Accuracies of 1 mu s are easily achieved for synchronization via GPS time, giving relative phase measurement accuracies of sigma =282 mu rad. A GPS receiver and synchronization system would be very small and potentially inexpensive, as the prices of GPS receivers are decreasing rapidly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Relationship between Optical Properties and Optimized Processing Parameters for through-Transmission Laser Welding of Thermoplastics (2004)

In previous studies, the results of an optical characterization (laser energy transmission, absorption, etc.) at a wide range of infrared wavelength for various nylon based plastics (unfilled and reinforced) with the influence of various colorants have been reported. In conjunction with these results, an analysis on optimized mechanical performance of the laser welded joints was also reported. In this current paper, we will try to increase the understanding of the plastics engineering community regarding the relations between optical properties of thermoplastics and optimized processing parameters of through-transmission laser welding (simultaneous welding mode).
Characterization of gene clusters encoding the fucoxanthin chlorophyll proteins of the diatom Phaeodactylum tricornutum (1993)

We are studying the multigene family encoding the fucoxanthin-chlorophyll binding proteins (fcp genes) that constitute the major component of the photosystem II-associated light harvesting complex in diatoms and brown algae. The characteristics of clusters of fcp genes on the genome of the diatom Phaeodactylum tricornutum are described. Sequence analysis of two genomic clones, PT5 and PT4, has demonstrated the presence of four fcp genes (fcpA, fcpB, fcpC, fcpD) on the former and two fcp genes (fcpE, fcpF) on the latter. The proteins encoded by the six characterized fcp genes range in similarity from 86% to 99%. The genes within each cluster are separated by short intergenic sequences (between 0.5 to 1.1 kb). None of these genes contain introns and all appear to be transcribed with short 5' transcribed, untranslated leader sequences; the transcription initiation sites were mapped 26 to 48 bases upstream of the ATG translation start site. Small conserved motifs are found among all of the genes just upstream of both the translation and the transcription start sites. The codon bias is similar in all of the fcp genes, with a predominance of pyrimidines in the third positions of codons of the four codon families. The two fcp genes that are most similar are fcpC and fcpD, and might represent a recent gene duplication. Southern analyses using fcp cDNAs as hybridization probes suggest that there may be additional sequences on the P. tricornutum genome that resemble the characterized fcp sequences.
Using reverse dynamic I–V characteristics of AlGaAs/GaAs optothyristor for pulsed power-switching applications (1992)

The reverse dynamic current-voltage (I–V) characteristics of a high performance MBE grown AIGaAs/GaAs based heterostructure optothyristor have been studied for high power pulsed switching applications. Switched current and dissipated energy per switching as a function of the blocking voltage are presented. Possible reverse switching mechanisms are also discussed in terms of the novel device structure.
Effects of luzopeptins on protein B23 translocation and ribosomal RNA synthesis in HeLa cells. (1986)

Localization of protein B23 in HeLa cells after treatment with luzopeptin A and its analogues was studied using indirect immunofluorescence. Bright nucleolar fluorescence was observed in control HeLa cells. After treatment with luzopeptin A (50 ng/ml), luzopeptin B (500 ng/ml), or luzopeptin D (10 ng/ml) for 2 h, uniform nucleoplasmic rather than specific nucleolar fluorescence was observed. Luzopeptin C had no effect on protein B23 translocation. Luzopeptin D, A, and B inhibited [3H]uridine incorporation into the trichloroacetic acid insoluble fraction of HeLa cells with 50% inhibitory concentration values of 3.7 +/- 1.1 (SD), 10.8 +/- 2.1, and 122.0 +/- 34.0 ng/ml, respectively. Less than 10% inhibition of [3H]uridine incorporation was found with luzopeptin C (500 ng/ml and 2 h incubation). Ribosomal RNAs (28 and 18S) were isolated from HeLa cells treated with luzopeptin D (50 ng/ml; 2 h). They were then separated and analyzed in 1% agarose gel electrophoresis. There were 90.1 +/- 1.38 and 95.0 +/- 1.04% inhibition of [3H]uridine incorporation into 28 and 18S ribosomal RNA, respectively. The order of potency for the loss of nucleolar fluorescence and the concurrent increase in nucleoplasmic fluorescence was luzopeptin D greater than luzopeptin A greater than luzopeptin B much greater than luzopeptin C, which correlates with the order of their 50% inhibitory concentration values for inhibition of [3H]uridine incorporation. With 34-55% inhibition of RNA synthesis, both nuclear and nucleolar B23 immunofluorescence were observed. With 70-85% inhibition of RNA synthesis, a uniform nucleoplasmic fluorescence was observed. These results indicate that translocation of protein B23 as observed by indirect immunofluorescence may be a rapid and simple screening test for the selection of antitumor agents which inhibit ribosomal RNA synthesis.
IPv6 in 3rd Generation Partnership Project (3GPP) Evolved Packet System (EPS) (2012)

The use of cellular broadband for accessing the Internet and other data services via smartphones, tablets, and notebook/netbook computers has increased rapidly as a result of high-speed packet data networks such as HSPA, HSPA+, and now Long-Term Evolution (LTE) being deployed. Operators that have deployed networks based on 3rd Generation Partnership Project (3GPP) network architectures are facing IPv4 address shortages at the Internet registries and are feeling pressure to migrate to IPv6. This document describes the support for IPv6 in 3GPP network architectures.
Complete assignments of <sup>1</sup>H and <sup>13</sup>C NMR data for two new sesquiterpenes from <i>Cyperus rotundus</i> L. (2009)

Two new sesquiterpenes, epi-guaidiol A (1) and sugebiol (3), together with four known sesquiterpenes, guaidiol A(2), sugetriol triacetate (4), cyperenoic acid (5), and cyperotundone (6) were isolated from the rhizomes of Cyperus rotundus L. Their structures were identified by MS and NMR experiments, and the complete assignments of (1)H and (13)C NMR data for two new sesquiterpenes were obtained by the aid of two-dimensional (2D) NMR techniques, including HSQC, HMBC, (1)H-(1)HCOSY and nuclear overhauser enhancement spectroscopy(NOESY).
Expression of functional CD40 in human hepatocellular carcinoma (1999)

CD40, a member of the tumor necrosis factor receptor (TNFR) family, plays a crucial role in the survival, proliferation, and differentiation in B cells. However, the expression of CD40 other than in B cells has not been well studied. Therefore, we investigated the expression and function of CD40 in hepatocellular carcinomas (HCCs). Expression of CD40 mRNA in 6 established HCC cell lines was analyzed by reverse-transcription polymerase chain reaction (RT-PCR) and CD40 expression on cell surface was examined by flow cytometrical analysis. We also examined the expression of CD40 in human HCC tissues (45 cases) and nontumor liver tissues (30 cases) by immunohistochemistry. To examine the function of CD40 in HCC cells, we investigated the effect of CD40 signaling on anti-Fas antibody and TNF-alpha-induced apoptosis in HepG2 cells. In addition, intracellular levels of cysteine protease P32 (CPP32) protein in HepG2 cells were also determined by Western blotting. We have shown that 6 HCC cell lines constitutively expressed CD40 mRNA and membrane-bound CD40 antigen, which was slightly up-regulated by interferon gamma (IFN-gamma). In addition, 60% of human HCC tissues demonstrated positive staining for CD40, whereas nontumor tissues showed little detectable staining. In HepG2 cells, CD40 stimulation does not affect cell viability, but significantly inhibited Fas and TNFR-mediated apoptosis in a dose-dependent manner by blocking the activation of CPP32. From these results, we conclude that CD40 expression in HCCs plays an important role in tumor biology, especially the resistance against Fas and TNFR-mediated apoptosis.
The angular distribution of neutral poly‐alanine molecules produced in a matrix‐assisted laser desorption/ionization process (1999)

The angular distribution of desorbed neutral and ionized polyalanine molecules, initially embedded in a matrix of 2,5-dihydroxybenzoic acid, has been measured for the first time. The target was irradiated with a pulsed ultraviolet laser beam (355 nm) incident at an angle of 26 ° with respect to the target normal. The desorbed molecules were collected on silica plates in a hemispherical array and the amount of collected material on each plate was determined using a standard amino acid analysis technique. Alanine polypeptides (14–70 residues) were used as analyte in order to increase the sensitivity of the amino acid analysis of the collector plates. In order to desorb more molecules, the laser fluence used was about three to ten times higher than in normal MALDI applications. In the plane encompassing the laser beam and the surface normal, the distribution is shifted about 13 ° towards the incident laser direction, whereas a nearly symmetric angular distribution is observed in the perpendicular plane. The relevance of these results for desorption models is discussed in terms of a recent analysis. Copyright © 1999 John Wiley & Sons, Ltd.
Web mining and its SQL based parallel execution (2001)

Web mining can be classified into two categories, Web access log mining and Web structure mining. We performed association rule mining and sequence pattern mining against the access log which was accumulated at NTT Software Mobile Info Search portal site. Detail web log mining process and the rules we derived are reported in this paper. The parallel association rule mining is explored on large scale PC cluster system. Parallelism is key to improve the performance. We achieved substantial speed up through parallel SQL execution.
Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex (2012)

EZH2 and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development. Regulation of EZH2 by ANCCA emphasizes bromodomain protein ANCCA as a potential therapeutic target against prostate cancer.
Sensitivity of environmental microorganisms to antimicrobial agents (1976)

The sensitivity of different microorganisms, considered as typical representatives of the microflora of soil and water, was established to evaluate the influence of the nonmedical use of antimicrobial agents on bacterial ecology. Only seven strains, six chemoorganotrophs and one chemolithotroph, could be considered as relatively sensitive to the 21 antimicrobial compounds tested. The other 29 microorganisms may be regarded as resistant to most antimicrobial agents. Streptomyces were sensitive to high concentrations of active substances. Broad-spectrum antibiotics showed an effect on environmental bacteria similar to that on human pathogens. Cephalothin stimulated the growth of a Chlorella sp. From these experiments, it appears that spilled antimicrobial agents have little chance of causing an alteration in the microbial ecology.