gebhart/patrepeval huggingface dataset:
Semi-continuous Extraction of Bio-alcohols using Supercritical Carbon Dioxide (2017)

This project examines the extraction efficiency of n-butanol, isobutanol, n-pentanol, and n-hexanol from aqueous solutions using supercritical CO2. The effect of varying scCO2 flow rates, initial alcohol concentration, and alcohol chain length on extraction efficiency was determined. Low scCO2 flow rates, high initial alcohol concentration, and longer alcohol chain length represented the most efficient extraction conditions. Overall mass transfer coefficients for each condition were estimated using a two-film mass transfer model. Additionally, the partition coefficient for each condition was calculated. Based on these findings, it was determined that extraction runs of longer chain alcohols at low scCO2 flow rates are more likely to be equilibrium limited.
The differentiation <i>in vitro</i> of the neural crest cells of the mouse embryo (1984)

A culture method for neural crest cells of mouse embryo is described. Trunk neural tubes were dissected from 9-day mouse embryos and explanted in culture dishes. The developmental potential of mouse neural crest in vitro was shown to be essentially similar to that of avian neural crest. In the mouse, however, melanocytes always appeared in association with the epithelial sheet close to the explant. Neural crest cells surrounding the epithelial sheet, which probably migrated from the neural tubes in the early culture phase, never differentiated into melanocytes. The bimodal behaviour of mouse crest cells seems to be due to the heterogenous potency of the crest cells and the interaction of these cells with the surrounding microenvironment. This culture system is well suited for various experiments including the analysis of gene control on the differentiation of neural crest cells.
A new approach for event detection and feature extraction for NILM (2014)

The method proposed in this paper aims both to detect the events occurring in overall current measurement and to estimate the features of the electric load underlying these events. This method is within the scope of the non-intrusive approach consisting of extraction of information from electric consumption measured only at the electrical switchboard.
Desire Denied: A Bibliographic Overview of Sexual Inequality and Blind Women (2006)

This literature review examines social science research on blind women’s experiences with sexual relationships. The findings suggest that socially constructed barriers marginalize blind women, often resulting in blind women being labeled as asexual. The intersection of able-ism and sexism positions many blind women as outsiders who do not possess sexual attractiveness. After discussing perspectives that examine socially constructed barriers rather than biological barriers to blind women’s sexuality, the paper reviews some consequences of denied sexuality, such as exclusion from heterosexual and homosexual relationships and increased risk of violence. The paper concludes with suggestions on how to challenge socially constructed barriers and a call for further on blind women’s experiences with sexual relationships.
Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities (2013)

Histone deacetylase inhibitors (HDACi) are anticancer agents that induce hyperacetylation of histones, resulting in chromatin remodeling and transcriptional changes. In addition, nonhistone proteins, such as the chaperone protein Hsp90, are functionally regulated through hyperacetylation mediated by HDACis. Histone acetylation is thought to be primarily regulated by HDACs 1, 2, and 3, whereas the acetylation of Hsp90 has been proposed to be specifically regulated through HDAC6. We compared the molecular and biologic effects induced by an HDACi with broad HDAC specificity (vorinostat) with agents that predominantly inhibited selected class I HDACs (MRLB-223 and romidepsin). MRLB-223, a potent inhibitor of HDACs 1 and 2, killed tumor cells using the same apoptotic pathways as the HDAC 1, 2, 3, 6, and 8 inhibitor vorinostat. However, vorinostat induced histone hyperacetylation and killed tumor cells more rapidly than MRLB-223 and had greater therapeutic efficacy in vivo. FDCP-1 cells dependent on the Hsp90 client protein Bcr-Abl for survival, were killed by all HDACis tested, concomitant with caspase-dependent degradation of Bcr-Abl. These studies provide evidence that inhibition of HDAC6 and degradation of Bcr-Abl following hyperacetylation of Hsp90 is likely not a major mechanism of action of HDACis as had been previously posited.
Lip features automatic extraction (2002)

An algorithm for speaker's lip segmentation and features extraction is presented. A color video sequence of speaker's face is acquired, under natural lighting conditions and without any particular make-up. First, a logarithmic color transform is performed from the RGB to HI (hue, intensity) color space. Second, a statistical approach using Markov random field modeling determines the red hue prevailing region and motion in a spatiotemporal neighborhood. Third, the final label field is used to extract ROI (region of interest) and geometrical features.
Testing android apps through symbolic execution (2012)

There is a growing need for automated testing techniques aimed at Android apps. A critical challenge is the systematic generation of test cases. One method of systematically generating test cases for Java programs is symbolic execution. But applying symbolic execution tools, such as Symbolic Pathfinder (SPF), to generate test cases for Android apps is challenged by the fact that Android apps run on the Dalvik Virtual Machine (DVM) instead of JVM. In addition, Android apps are event driven and susceptible to path-divergence due to their reliance on an application development framework. This paper provides an overview of a two-pronged approach to alleviate these issues. First, we have developed a model of Android libraries in Java Pathfinder (JPF) to enable execution of Android apps in a way that addresses the issues of incompatibility with JVM and path-divergence. Second, we have leveraged program analysis techniques to correlate events with their handlers for automatically generating Android-specific drivers that simulate all valid events.
Magnesium hydroxide nanoplate/graphene oxide composites as efficient adsorbents for organic dyes (2015)

Mg(OH)<sub>2</sub> nanoplates/graphene oxide nanocomposites: controlled synthesis of Mg(OH)<sub>2</sub> nanoplates on the GO surface and the use of the resulting nanocomposites for efficient removal of dyes are presented.
Mechanical and Barrier Properties of Edible Chitosan Films as affected by Composition and Storage (1996)

ABSTRACT Oxygen permeability coefficients (OP), water vapor permeability coefficients (WVP), ethylene permeability coefficients (EP), tensile strength (TS) and percent elongation (%E) at break values were determined for chitosan films plasticized with glycerin at two concentrations (0.25 and 0.50 mL/g chitosan). Film samples were tested after 0, 2, 4, 8 and 12 wk of storage. After an initial drop in permeability during the first 2 wk of storage, mean OP (4.6 × 10 −5 cc/m‐day‐atm) and mean EP (2.3 × 10 −4 cc./m.day.atm) remained constant while mean WVP (2.2 × 10 −1 g/m‐day‐atm) decreased with respect to storage time. TS values (15–30 MPa) decreased and %E values (25%–45%) increased with respect to storage time. The stability of OP and EP values with storage was not expected, while the change in mechanical properties was as expected.
Interspecific hybrids between the soybean and wild perennial relatives (1987)

Journal Article Interspecific hybrids between the soybean and wild perennial relatives Get access C. A. Newell, C. A. Newell The authors are, respectively, research specialist, research group leader, and former research biologist I (currently research assistant, Department of Agronomy and Range Science, University of California, Davis, CA 95616), Monsanto Company, 700 Chesterfield Village Parkway, St. Louis, MO 63198. A part of this research was conducted by C. A. Newell at Advanced Genetic Sciences, Inc., 6701 San Pablo Avenue, Oakland, CA 94608. She gratefully acknowledges Advanced Genetic Sciences for its support in this project. Search for other works by this author on: Oxford Academic PubMed Google Scholar X. Delannay, X. Delannay The authors are, respectively, research specialist, research group leader, and former research biologist I (currently research assistant, Department of Agronomy and Range Science, University of California, Davis, CA 95616), Monsanto Company, 700 Chesterfield Village Parkway, St. Louis, MO 63198. A part of this research was conducted by C. A. Newell at Advanced Genetic Sciences, Inc., 6701 San Pablo Avenue, Oakland, CA 94608. She gratefully acknowledges Advanced Genetic Sciences for its support in this project. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. E. Edge M. E. Edge The authors are, respectively, research specialist, research group leader, and former research biologist I (currently research assistant, Department of Agronomy and Range Science, University of California, Davis, CA 95616), Monsanto Company, 700 Chesterfield Village Parkway, St. Louis, MO 63198. A part of this research was conducted by C. A. Newell at Advanced Genetic Sciences, Inc., 6701 San Pablo Avenue, Oakland, CA 94608. She gratefully acknowledges Advanced Genetic Sciences for its support in this project. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 78, Issue 5, September 1987, Pages 301–306, https://doi.org/10.1093/oxfordjournals.jhered.a110392 Published: 01 September 1987
Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not <scp>l</scp>-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothrombin time and the mutation site in the variant proteins (1990)

Previously, from the plasma of unrelated haemophilia-B patients, we isolated two non-functional Factor IX variants, namely Los Angeles (IXLA) and Long Beach (IXLB). Both variants could be cleaved to yield Factor IXa-like molecules, but were defective in catalysing the cleavage of Factor X (macromolecular substrate) and in binding to antithrombin III (macromolecular inhibitor). In the present study we have identified the mutation of IXLA by amplifying the exons (including flanking regions) as well as the 5' end of the gene by polymerase-chain-reaction (PCR) method and sequencing the amplified DNA by the dideoxy chain-termination method. Comparison of the normal IX and IXLA sequences revealed only one base substitution (T----C) in exon VIII of IXLA, with a predicted replacement of Ile-397 to Thr in the mature protein. This mutation is the same as found recently for IXLB. The observation that IXLB and IXLA have the same mutation is an unexpected finding, since, on the basis of their ox brain prothrombin time (PT, a test that measures the ability of the variant Factor IX molecules to inhibit the activation of Factor X by Factor VIIa-tissue factor complex), these variants have been classified into two different groups and were thought to be genetically different. Our observation thus suggests that the ox brain PT does not reflect the locus of mutation in the coding region of the variant molecules. However, our analysis suggests that the ox brain PT is related to Factor IX antigen concentration in the patient's plasma. Importantly, although the mutation in IXLA or IXLB protein is in the catalytic domain, purified IXaLA and IXaLB hydrolyse L-tosylarginine methyl ester at rates very similar to that of normal IXa. These data, in conjunction with our recent data on Factor IXBm Lake Elsinore (Ala-390----Val mutant), strengthen a conclusion that the peptide region containing residues 390-397 of normal Factor IXa plays an essential role in macromolecular substrate catalysis and inhibitor binding. However, the two mutations noted thus far in this region do not distort S1 binding site in the Factor IXa enzyme.
WaveCube: A scalable, fault-tolerant, high-performance optical data center architecture (2015)

Optical data center networks (DCNs) are becoming increasingly attractive due to their technological strengths compared to traditional electrical networks. However, prior optical DCNs are either hard to scale, vulnerable to single point of failure, or provide limited network bisection bandwidth for many practical DCN workloads. To this end, we present WaveCube, a scalable, fault-tolerant, high-performance optical DCN architecture. To scale, WaveCube removes MEMS <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> , a potential bottleneck, from its design. Wave-Cube is fault-tolerant since it does not have single point of failure and there are multiple node-disjoint parallel paths between any pair of Top-of-Rack (ToR) switches. WaveCube delivers high performance by exploiting multi-pathing and dynamic link bandwidth along the path. Our extensive evaluation results show that WaveCube outperforms previous optical DCNs by up to 400% and delivers network bisection bandwidth that is 70%–85% of an ideal non-blocking network under both realistic and synthetic traffic patterns. WaveCube's performance degrades gracefully under failures — it drops 20% even with 20% links cut. WaveCube also holds promise in practice — its wiring complexity is orders of magnitude lower than Fattree, BCube and c-Through at large scale, and its power consumption is 35% of them.
Development Of A Field-Portable Imaging System for Scene Classification Multispectral Data Fusion Algorithms using (1994)

Battelle scientists have assembled a reconfigurable multispectral imaging and classification system which can be taken into the field to support automated real-time targetbackground discrimination. The system may be used for a variety of applications including environmental remote sensing, industrial inspection and medical imaging. This paper discusses hard tactical target and runway detection applications performed with the multispectral system. multispectral imaging electro-optical (EO) sensor suite and a real-time digital data collection and data fusion image processor. The EO sensor suite, able to collect imagery in 12 distinct wavebands from the ultraviolet (UV) through the long wave infrared (LWIR), consists of five charge-coupled device The Battelle-developed system consists of a passive,
Graphical approach to assembly tolerance stack analysis—the ‘Quickie’ GDT method (1997)

More industries are now aware of the importance of geometric dimensioning and tolerancing (GDT) to their product design. Conventional methods of tolerance stack analysis for GDT is tedious and time consuming. This paper presents an elegant approach by using the ‘Quickie’ technique towards tolerance stack analysis for GDT. The proposed approach has the potential to significantly reduce the amount of work required and computerization is proving to be promising. Two examples are used to illustrate the effectiveness of the method. The ‘Quickie’ GDT method is applicable to all geometric characteristics. However, due to different treatments in various families of geometric characteristics, this paper describes the ‘Quickie’ GDT approach towards analysing runout and concentricity tolerances.
TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis (2020)

Spondyloarthritis (SpA) represents a family of inflammatory diseases of the spine and peripheral joints. Ankylosing spondylitis (AS) is the prototypic form of SpA in which progressive disease can lead to fusion of the spine. Therapeutically, knowledge of type 3 immunity has translated into the development of IL-23- and IL-17A-blocking antibodies for the treatment of SpA. Despite being able to provide symptomatic control, the current biologics do not prevent the fusion of joints in AS patients. Thus, there is an unmet need for disease-modifying drugs. Genetic studies have linked the Janus kinase TYK2 to AS. TYK2 is a mediator of type 3 immunity through intracellular signaling of IL-23. Here, we describe and characterize a potentially novel small-molecule inhibitor of TYK2 that blocked IL-23 signaling in vitro and inhibited disease progression in animal models of SpA. The effect of the inhibitor appears to be TYK2 specific, using TYK2-inactive mice, which further revealed a duality in the induction of IL-17A and IL-22 by IL-23. Specifically, IL-22 production was TYK2/JAK2/STAT3 dependent, while IL-17A was mostly JAK2 dependent. Finally, we examined the effects of AS-associated TYK2 SNPs on TYK2 expression and function and correlated them with AS disease progression. This work provides evidence that TYK2 inhibitors have great potential as an orally delivered therapeutic for SpA.
Formation of Acicular Monoclinic Zirconia Particles under Hydrothermal Conditions (1989)

Acicular monoclinic ZrO 2 , particles were prepared by hydrothermal treatmentat 250°C using sulfuric acid solutions containing zirconium ions. The formation process and morphology of the ZrO 2 , particles were investigated. Two types of acicular monoclinic Zr0 2 , particle morphologies were obtained, both elongated in the 〈001〉 direction, and the range of acicular ZrO 2 , particle sizes changedfrom 0.3 to 1.3 μ m with hydrothermal conditions. Addition of MgSO 4 , to the starting solution promoted the crystallization of the monoclinic ZrO 2 , particles.
Operating lifetime of phosphorescent organic light emitting devices (2000)

We investigate the continuous operating lifetime of organic light emitting devices (OLEDs) using the phosphorescent dopant, 2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphine platinum (II) as the light emitting molecule. We characterize devices based on two different electron transporting hosts: tris-(8-hydroxyquinoline) aluminum and 4,4′-N,N′-dicarbazolyl-biphenyl (CBP). The OLEDs lose ∼25% of their luminance in the first 50 h of operation, followed by extremely slow degradation with negligible growth of dark spots. The device lifetime of CBP-based phosphorescent OLEDs projected to 50% initial brightness is &gt;107 h at a mean current density of 10 mA/cm2 under 50% duty cycle pulsed operation. These extremely long lifetimes are speculated to be an intrinsic property of electrophosphorescent OLEDs, where radiative phosphors significantly shorten the lifetime of potentially reactive triplet states in the conductive host material.
Heart on the Heart (2005)

A 44-year-old woman presented with exertional dyspnea and atypical chest pain.On physical examination, severe kyphotic deformity was noted.The ECG demonstrated rightaxis deviation and right ventricular hypertrophy.Echocardiography demonstrated normal left ventricular systolic function, no segmental wall-motion abnormality, and mild pulmonary hypertension.The pulmonary function test showed severe restrictive disease.An exercise treadmill test was attempted but terminated at stage 1 because of severe dyspnea.Coronary angiography was performed.A left anterior oblique-caudal view of left coronary angiography with a JL4 catheter showed no stenosis on the epicardial coronary arteries.The left anterior descending artery and left circumflex artery made a "heart" on the heart because of the counterclockwise rotation and the anterior displacement of the cardiac apex (Figure).Results of right coronary angiography were normal.The presumptive diagnosis was severe restrictive disease due to chest wall deformity.Left anterior oblique-caudal view of left coronary angiography.The left anterior descending artery and left circumflex artery make a "heart" on the heart.
Chitosan: evaluation of a new hemostatic agent. (1990)

Topically applied chitosan fails to improve the control of bleeding in a liver laceration model when compared to pressure alone in both normal and heparinized rats, and both chitosan and pressure alone are significantly less effective in controlling bleeding than the application of thrombin. In addition, our histologic results suggest that there may be an increased inflammatory response by the healing liver following topical application of chitosan.
Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide (2014)

Re(I) tricarbonyl polypyridine-based complexes are particularly attractive metal complexes in the field of inorganic chemical biology due to their luminescent properties, ease of conjugation to targeting biomolecules, and the possibility to prepare their "hot" (99m)Tc analogues for radioimaging. In this study, we prepared and characterized a novel, "clickable" complex, [Re(2,2'-bipyridine)(3-ethynylpyridine)(CO)3](BF4) ([Re(CO) 3 (bipy)(py-alkyne)](BF 4 )), exhibiting the characteristic luminescent properties and moderate cytotoxicity of this general class of compound. Using Cu(I)-catalyzed "click" chemistry, the complex was efficiently attached to a lipidated peptide known to increase cell permeability, namely, the myristoylated HIV-1 Tat peptide (myr-Tat), to give Re-myr-Tat. Fluorescence microscopy localization in human cervical cancer cells (HeLa) confirmed enhanced cellular uptake of Re-myr-Tat compared with [Re(CO) 3 (bipy)(py-alkyne)](BF 4 ), and cytotoxicity studies showed that this resulted in an increase in potency to a level comparable with cisplatin (13.0 ± 2.0 μM).
Plasma fibrinogen as prognostic predictor in patients with metastatic renal cell carcinoma receiving target therapy (2018)

Background: The purpose of this work was to detect the influence of plasma fibrinogen level on the prognosis of patients with metastatic renal cell carcinoma (mRCC) before treatment of targeted therapy.
 Methods: We identified mRCC patients who received first-line therapy of sorafenib or sunitinib between January 2006 to December 2016 in Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine. Kaplan-Meier method was used to estimate the progression-free survival (PFS) and overall survival (OS); log-rank test was used to compare the survival outcomes between patients with low and high fibrinogen level; and cox proportional hazard regression model was used to estimate the prognostic value. Prognostic accuracy was determined using Harrell concordance index (C-index) and receiver operating curve (ROC) analysis.
 Results: Patients with high fibrinogen level both had significantly shorter median PFS (6 vs. 15 months, P<0.001) and OS (17 vs. 44 months, P<0.001) than those with low fibrinogen level. Multivariate analysis showed that pretreatment plasma fibrinogen was an independent predictor of PFS (HR 2.873, P<0.001) and OS (HR 3.213, P<0.001). The model built by the addition of fibrinogen improved predictive accuracy of PFS and OS compared with the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model [Harrell C-index: 0.74 and 0.76, AUC (area under the ROC curve): 0.863, P<0.001].
 Conclusions: High pretreatment plasma fibrinogen could be a significant risk factor for mRCC patients receiving target therapy and increase the prognostic accuracy of established prognostic model.