gebhart/patrepeval huggingface dataset:
Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects (2018)

The surface glycoprotein (GP) of Ebola virus causes many of the virus's pathogenic effects, including a dramatic loss of endothelial cell adhesion associated with widespread hemorrhaging during infection. Although the GP-mediated deadhesion depends on its extracellular mucin-like domain, it is unknown whether any, or all, of this domain's densely clustered <i>O</i>-glycosylation sites are required. It is also unknown whether any of the 20 distinct polypeptide GalNAc-transferases (ppGalNAc-Ts) that initiate mucin-type <i>O</i>-glycosylation in human cells are functionally required. Here, using HEK293 cell lines lacking specific glycosylation enzymes, we demonstrate that GP requires extended <i>O</i>-glycans to exert its deadhesion effect. We also identified ppGalNAc-T1 as largely required for the GP-mediated adhesion defects. Despite its profound effect on GP function, the absence of ppGalNAc-T1 only modestly reduced the <i>O</i>-glycan mass of GP, indicating that even small changes in the bulky glycodomain can cause loss of GP function. Indeed, protein-mapping studies identified a small segment of the mucin-like domain critical for function and revealed that mutation of five glycan acceptor sites within this segment are sufficient to abrogate GP function. Together, these results argue against a mechanism of Ebola GP-induced cell detachment that depends solely on ectodomain bulkiness and identify a single host-derived glycosylation enzyme, ppGalNAc-T1, as a potential target for therapeutic intervention against Ebola virus disease.
An approach to impact analysis in software maintenance (1994)

Impact analysis is a software maintenance activity, which consists of determining the scope of a requested change, as a basis for planning and implementing it. After a change request has been specified (change understanding) and the initial part of the system to be changed has been identified (change localization), impact analysis helps to understand consequences of the change on other parts of the system. Induced changes, also named ripple effects, among software components are detected. Most existing approaches perform impact analysis for changes occurring at the code level. In this thesis, concepts developed to perform impact analysis at the code level are applied to trace changes occurring at the design level. The method consists of proposing an activity model addressing the different steps of impact analysis and a data model on which propagations of changes can be traced. The method is validated with a case study applied to a system from the aerospace field. The tools we developed on PCTE help for consistency checks in HOOD based designs during editing. Our data-model based on an Entity Relationship notation describes a way to model HOOD diagrams in PCTE and further on to propagate changes on the repository. Examples chosen address the design phase of a simple engine system. We show that addressing modifications at a higher level of abstraction than the code eases understanding and localization of changes. It also limits the propagation of ripple effects (i.e., unexpected behaviour of the system) by detecting secondary changes at an earlier stage.
Rapid 7-dimensional imaging of pulsatile flow (2002)

A method is described for acquiring 7-dimensional information about flowing blood. The acquisition of the 7-dimensions, consisting of 3 spatial, 3 velocity and 1 time, enables a more complete study of blood flow patterns than had previously been possible. In order to reduce the scan time to acceptable levels, the method uses a 2-D selective r.f. pulse to excite a column of tissue and a limited number of phase encoding steps to spatially resolve across the short axes of the column. Phase velocity mapping is used to quantify velocities in 3 perpendicular directions. Recent hardware developments should enable rapid processing of the large data sets acquired.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mid-term Photometric Periodic Variations in Be Stars HR 1960 and HR 2968 (2000)

Abstract The Be stars HR 1960 and HR 2968 have been monitored from 1978 to 1998 in Geneva photometry and from November 1989 to March 1993 by the Hipparcos satellite. A spectroscopic survey of these stars started in September 1998. Both stars show luminosity variations with a period of 395 d and 371 d for HR 1960 and HR 2968 respectively.
Too many treatments for Parkinson's disease: how should they be used? (2000)

Surgical ablation for Parkinson's disease was abandoned in the 1970s after successful clinical trials of L-DOPA and L-DOPA/decarboxylase inhibitor combinations and early dopamine receptor agonists were added to prolong a viable therapeutic window beyond 5 years. The development of newer agonists with variations in receptor subtype specificity and new enzyme inhibitors with combinations of central and peripheral effects have continued to attract attention as therapeutic alternatives. Treatment options are now coming full circle with a rebirth of stereotactic neurosurgical alternatives to a wide variety of pharmacologic paradigms. The authors propose a rationale for selecting differing treatment options within historical perspective and modern treatment goals using both medical and surgical alternatives.
Influence of positioning of prosthesis in total knee replacement (1977)

The early clinical results of geometric total knee arthroplasty were compared with the position of the prosthetic device by a roentgenographic score system. It was noted that there is a statistically significant positive correlation between a good clinical result and a well positioned prosthesis. In addition, it was appreciated that perfect positioning of the device was difficult to obtain. We believe that the long-term clinical results, wear resistance, and resistance to prosthetic failure depend on correct positioning of the devices.
Optimization of Electroencephalograph-Based Classification for Imaginary Motion Brain Computer Interface Study (2016)

Using Electroencephalography (EEG) to detect imaginary motions from brain waves, is a very nascent and challenging field that started developing rapidly in the past few decades. EEG involves having some electrodes attached on the scalp of the patient to capture the brain signals generated through the patients thought process and record them in a computer. This technique of human and computer interfacing is called Brain Computer Interface (BCI). Disability is a serious problem of our nation and hence BCI can play an important role in facilitating the lives of people who are incapable of communicating due to spinal cord injuries. This technique uses the brain signals to make decisions, control objects and communicate with the world using brain integration with peripheral devices and systems. This requires some intelligence to classify these motions. Neural network have been used as a mean to classify motions, however, the accuracy of classification for certain motions was limited. The novelty of the proposed approach is in using a majority vote system for a network of artificial neural networks (ANNs) that is used to optimally classify imaginary motions performed by individual or multiple subjects. Three kinds of imaginary motions were classified which are imaginary left hand movement, imaginary right hand movement, and imagination of words starting with the same letter. Using an optimized set of electrodes, classification accuracy was optimized for the three users as a group and also individually. The optimization procedure was based on the ranking of the electrodes according to their 2 classification accuracy, electrodes with the lowest accuracies were eliminated to achieve the optimal accuracy. The group optimization of 3 subjects altogether resulted in an electrode structure consisting of 15 electrodes with a relatively high classification accuracy of almost 80%. The individual optimization for each subject resulted in structure of 20 electrodes for subject 1 and subject 3 with classification accuracies of 63.63% and 84.33%, respectively, and a single electrode structure for subject 2 with an accuracy of 94.01%. The overall average classification accuracy of all the users with the individual optimization of electrodes was as high as 82.32%. Index Words: Artificial Neural Network, Brain Computer Interface, Majority Vote, Electroencephalography OPTIMIZATION OF ELECTROENCEPHALOGRAPH-BASED CLASSIFICATION FOR IMAGINARY MOTION BRAIN COMPUTER INTERFACE STUDY by SYLVIA BHATTACHARYA B.S, West Bengal University Of Technology, India, 2013 A Thesis Submitted to the Graduate Faculty of Georgia Southern University in Partial Fulfillment of the Requirement for the Degree
Exenatide in obesity with accelerated gastric emptying: a randomized, pharmacodynamics study (2015)

Obesity is associated with differences in satiety, gastric emptying (GE), gastric volume, and psychological traits. Exenatide, a short-acting glucagon-like peptide 1 (GLP-1) receptor agonist, is associated with variable weight loss. We compared the effects of exenatide, 5 μg, and placebo SQ, twice daily for 30 days on GE of solids and liquids (scintigraphy), satiety (ad libitum buffet meal), satiation (nutrient drink test, maximum tolerated volume [MTV]), and weight loss in 20 participants with documented accelerated GE of solids (T1/2 < 90 min). Exenatide delayed GE of solids (T1/2 [Δ] 86 min relative to placebo, P < 0.001) and reduced calorie intake at buffet meal ([Δ] 129 kcal compared to placebo). Median weight loss was -0.95 kg (IQR -0.7 to -2.1) for exenatide and -0.55 kg (0.3 to -2.1) for placebo (P = 0.23); 80% of exenatide group had documented reduction in weight. In the exenatide treatment group, there was an inverse correlation between gastric emptying T1/2 and MTV (R = -0.548, P = 0.089). The univariate association of weight change with posttreatment MTV was borderline (Rs = 0.43, P = 0.06); in the multiple regression model, posttreatment MTV was associated with weight change (P = 0.047). The effect of the short-acting GLP-1 receptor agonist, exenatide, on GE is associated with the change in food intake, and the latter impacts weight loss in response to exenatide treatment.
Integrated estimation of interval-attenuation profiles (2006)

Abstract Quantitative estimates of seismic attenuation are useful for a variety of applications, ranging from seismic-acquisition design, to seismic processing, amplitude analysis, and reservoir characterization. I frame the estimation of interval attenuation from a set of seismic wavelets as a linear inversion of their log-amplitude spectra. The initial spectrum at the first depth location and a set of depth-varying amplitude scalers are estimated simultaneously with an effective-attenuation (Q−1) profile. The algorithm can be regarded as a tomographic extension of the spectral-ratio method that uses all the information available in the amplitude spectra, appropriately weighted so that estimates are not biased by noise. Constraints can be applied to ensure the Q−1 values vary smoothly, and solving for log Q rather than Q−1 ensures only positive attenuation values. Tests on synthetic and field data illustrate the trade-off between vertical resolution and sensitivity to noise. A covariance study indicates that improvements in interval-attenuation estimates over the traditional spectral-ratio method come from systematic-noise handling and the explicit constraints on Q−1, rather than the fact that the inversion ties the log-spectral data together with a single estimate of the spectrum at the first depth location.
Discoidin Domain Receptor 1 on Bone Marrow–Derived Cells Promotes Macrophage Accumulation During Atherogenesis (2009)

Taken together, our data support an independent and critical role for DDR1 in macrophage accumulation at early and late stages of atherogenesis.
A large product of cell-free translation of messenger RNA coding for corticotropin. (1976)

Polyadenylate-containing RNA prepared from the membrane fraction of bovine anterior pituitary gland was shown to direct the synthesis of a large translation product related to corticotropin (adrenocorticotropic hormone) in a cell-free system derived from wheat germ. This product was identified by immunoprecipitation with specific antibody against corticotropin, followed by electrophoretic analysis of the dissociated immunoprecipitate on sodium dodecyl sulfate-polyacrylamide gel. Further evidence for the identity of the translation product was provided by the presence of a common peptide in the chymotryptic digest of [35S]methionine-labeled cell-free product and in that of authentic corticotropin. The molecular weight of the translation product was estimated to be approximately 35,000, based on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These results indicate that corticotropin messenger RNA directs the cell-free synthesis of a product that contains the amino acid sequence of corticotropin but is much larger than this hormone.
Binding of Thrombin to Glycoprotein Ib Accelerates the Hydrolysis of Par-1 on Intact Platelets (2001)

The activation of human platelets by alpha-thrombin is mediated at least in part by cleavage of protease-activated G-protein-coupled receptors, PAR-1 and PAR-4. Platelet glycoprotein Ibalpha also has a high affinity binding site for alpha-thrombin, and this interaction contributes to platelet activation through a still unknown mechanism. In the present study the hypothesis that GpIbalpha may contribute to platelet activation by modulating the hydrolysis of PAR-1 on the platelet membrane was investigated. Gel-filtered platelets from normal individuals were stimulated by alpha-thrombin, and the kinetics of PAR-1 hydrolysis by enzyme was followed with flow cytometry using an anti-PAR-1 monoclonal antibody (SPAN 12) that recognizes only intact PAR-1 molecules. This strategy allowed measurement of the apparent k(cat)/K(m) value for thrombin hydrolysis of PAR-1 on intact platelets, which was equal to 1.5 +/- 0.1 x 10(7) m(-1) sec(-1). The hydrolysis rate of PAR-1 by thrombin was measured under conditions in which thrombin binding to GpIb was inhibited by different strategies, with the following results. 1) Elimination of GpIbalpha on platelet membranes by mocarhagin treatment reduced the k(cat)/K(m) value by about 6-fold. 2) A monoclonal anti-GpIb antibody reduced the apparent k(cat)/K(m) value by about 5-fold. 3) An oligonucleotide DNA aptamer, HD22, which binds to the thrombin heparin-binding site (HBS) and inhibits thrombin interaction with GpIbalpha, reduced the apparent k(cat)/K(m) value by about 5-fold. 4) Displacement of alpha-thrombin from the binding site on GpIb using PPACK-thrombin reduced the apparent k(cat)/K(m) value by about 5-fold, and 5) mutation at the HBS of thrombin (R98A) caused a 5-fold reduction of the apparent k(cat)/K(m) value of PAR-1 hydrolysis. Altogether these results show that thrombin interaction with GpIb enhances the specificity of thrombin cleavage of PAR-1 on intact platelets, suggesting that GpIb may function as a "cofactor" for PAR-1 activation by thrombin.
Hypotensive 1,2-Benzisothiazole 1,1-Dioxides. I. Pyrazole and Pyrazoline Derivatives (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypotensive 1,2-Benzisothiazole 1,1-Dioxides. I. Pyrazole and Pyrazoline DerivativesJohn J. Traverso, Calvert W. Whitehead, James F. Bell, Harold E. Boaz, and Paul W. WillardCite this: J. Med. Chem. 1967, 10, 5, 840–844Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/jm00317a018https://doi.org/10.1021/jm00317a018research-articleACS PublicationsRequest reuse permissionsArticle Views201Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
공공시설에서의 분산식 빗물관리 시설 설치 및 효과분석 (2015)

Nowadays interest on decentralized rainwater management facilities by increase of rainwater discharge due to urbanization and effort to reduce discharge is in progress. However unlike overseas advanced countries, legal institutional systems are lacked and is inefficient in our country. Therefore in this paper, effectiveness analysis was conducted subject on Cheongam School located in Jecheon-si by installing a decentralized rainwater management facility and monitoring it. Discharge was not shown in result of monitoring that it can be judged that rainwater discharge due to climate change can be reduced and damages from floods or landslides can be reduced in which it can become a significant factor in aspect of disaster preventing.
Fine rectangular magnet wires with ultra thin insulation and its applications (2003)

Typically rectangular magnet wires have been used for conductors larger than approx. 2 sq.mm. Fine rectangular wires showed poor performance, because of difficulties in building uniform insulation on fine rectangular conductors. Conventionally, round magnet wires were used for fine sizes. Mitsubishi Cable Industries, Ltd., have developed MEDIS (Mitsubishi Electro-Deposition Insulating System) which is a very unique system for producing magnet wires. We developed a fine rectangular magnet wire ("SX WIRE") with very good performance through this MEDIS process. We were also successful in making an ultra thin insulation with very good uniformity. The following issues are reported in this paper: fine rectangular magnet wires by MEDIS; ultra thin insulation (min. 0.001 mm) rectangular magnet wires; characteristics of ultra thin insulation wires; advanced MEDIS process for fine rectangular magnet wires; and applications and advantages of applied devices.
Intake Rate: Cylinder Infiltrometer (1986)

Cylinder infiltrometers are metal cylinders that are pushed or driven a small distance into the soil. The area inside the cylinder is flooded with water and the rate at which water moves into the ground is measured. When using infiltrometers to predict infiltration rates for a given system, one must be careful that the conditions of that system such as water quality, temperature, soil conditions, surface conditions are duplicated as much as possible with the infiltrometer so that the measurement is realistic. Infiltration of water into soil from surface inundations can be described by the Green-Ampt theory, which considers the infiltrated water to advance downward in the soil as piston flow. Double-cylinder infiltrometers could be effective only where there is a surface crust, an impeding layer on the surface, or other soil condition that makes it difficult to get a good bond between the undisturbed soil and the cylinder wall.
The possible role of endogenous digitalis-like substance in the causation of pre-eclampsia. (1984)

Digoxin levels have been reported in neonatal blood when neither the mother nor the baby had received digoxin. An endogenous digoxin-like substance (DLS) that may be causally related to hypertension has been described. Using a commercially available radioimmunoassay kit, we investigated the presence of an immunoreactive DLS in 21 pre-eclamptic mothers, 36 mothers with normal blood pressure (the control group) and their infants. We found mean DLS levels to be higher in cord blood from infants born to the pre-eclamptic mothers than in cord blood from those born to mothers in the control group. Levels were also higher in cord blood than in maternal blood in both the pre-eclamptic and the control groups. DLS seems to be associated with pre-eclampsia. Although further work is needed for verification, a hypothesis on the possible role of DLS in the causation of pre-eclampsia is presented.
Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'. (2000)

Paclitaxel is an antimicrotubule agent that induces mitotic block and apoptosis. We show for the first time that paclitaxel acts directly or mitochondria isolated from human cancer cells. In isolated yeast mito chondria, paclitaxel (15 microM) induced an 18% increase in the respiration rate, with no concomitant release of cytochrome c. In isolated neuroblas toma mitochondria, paclitaxel (10-100 microM) induced a 27-72% release o cytochrome c. Release was prevented by cyclosporin A, suggesting the involvement of the permeability transition pore. Doxorubicin did no induce cytochrome c release, whereas vinorelbine, another antimicrotu bule agent, did. Thus, antimicrotubule agents can directly affect mito chondria to induce apoptosis.
Wide-band, wide-angle microstrip stacked-patch-element phased arrays (1991)

The feasibility of a probe-fed, microstrip-stacked-patch element for wideband phased arrays scanned from broadside to about 45 degrees in two planes is established through computer simulation. The implementation of a systematic interactive design procedure of such phased array elements is described. The authors describe the array model, present the main steps in the analysis of scan and frequency gain performance, and consider various aspects of convergence acceleration. An iterative stacked-phased-array-element design procedure is developed. The method is facilitated by identification of the individual uncoupled resonant configurations of the stagger-tuned patch system. The authors present samples of numerical results for active resistance and reflection coefficient for single probe excitation, and some useful transmission line relations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Memory-efficient decoding of LDPC codes (2005)

We present a low-complexity quantization scheme for the implementation of regular (3,6) LDPC codes. The quantization parameters are optimized to maximize the mutual information between the source and the quantized messages. Using this non-uniform quantized belief propagation algorithm, we have simulated that an optimized 3-bit quantizer operates with 0.2 dB implementation loss relative to a floating point decoder, and an optimized 4-bit quantizer operates less than 0.1 dB quantization loss
Zum (I. S.), רבי עקיבה [Rabbi Akiba], 1924 (1923)

Back Abraham. Zum (I. S.), רבי עקיבה [Rabbi Akiba], 1924. In: Revue des études juives, tome 77, n°154, octobre-décembre 1923. pp. 203-206.
High Precision STEM Imaging by Non-Rigid Alignment and Averaging of a Series of Short Exposures (2012)

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.