gebhart/patrepeval huggingface dataset:
Repair of a synthetic abasic site in DNA in a Xenopus laevis oocyte extract. (1989)

Covalently closed circular DNA containing a synthetic analog of an abasic site at a unique position was used as a substrate to study DNA repair. Incubation of this DNA in Xenopus laevis oocyte extracts resulted in rapid cleavage of the DNA at the abasic site by a class II apurinic-apyrimidinic endonuclease, followed by complete repair within 40 min. Nicked circular DNAs persisted for several minutes before repair by an ATP-dependent DNA synthesis reaction. The repair-related DNA synthesis was localized within 3 or 4 nucleotides surrounding the abasic site. These results are consistent with the short-patch repair reported for DNA damage at heterogeneous sites in human cells (J. D. Regan and R. B. Setlow, Cancer Res. 34:3318-3325, 1974).
Les images parlantes de Thomas Wynterhop (1992)

Thomson David, Bouniort Jeanne. Les images parlantes de Thomas Wynterhop. In: Revue de l'Art, 1992, n°98. pp. 29-38.
Bundle-Branch Reentry and the Postpacing Interval After Entrainment by Right Ventricular Apex Stimulation (2001)

A PPI-TCL >30 ms, after entrainment by RVA stimulation, makes BBR-VT unlikely. Conversely, a PPI-TCL <30 ms is suggestive of BBR-VT but should lead to further investigation by use of conventional criteria.
The power system challenge-understanding the total picture (2003)

The task of designing an optimal power system for a server system is very challenging. For a power supply vendor, understanding the specific application is very critical to recommend alternate power system architectures that are more suitable than what the customer has in mind. The paper covers various issues and trade off for designing a power system specifically for server applications. AC redundancy, AC/DC redundancy and DC/DC redundancy issues are described for the systems and an effort is made to highlight some very important issues concerning power system availability, imbedded or plug-in regulators, and centralized power systems versus distributed power architectures. The availability, the flexibility and the cost trade off are covered using specific examples. Ultimately, it is the power system designer's responsibility to have in-depth knowledge of the server system and future technology trends if a cost effective power system has to be designed.
Preclinical Properties of <sup>18</sup>F-AV-45: A PET Agent for Aβ Plaques in the Brain (2009)

(18)F-AV-45 displayed a high binding affinity and specificity to Abeta plaques (K(d), 3.72 +/- 0.30 nM). In vitro autoradiography of postmortem human brain sections showed substantial plaque labeling in AD brains and not in the control brains. Initial high brain uptake and rapid washout from the brain of healthy mice and monkey were observed. Metabolites produced in the blood of healthy mice after an intravenous injection were identified. (18)F-AV-45 displayed excellent binding affinity to Abeta plaques in the AD brain by ex vivo autoradiography in transgenic AD model mice. The results lend support that (18)F-AV-45 may be a useful PET agent for detecting Abeta plaques in the living human brain.
A phrase-based alignment model for natural language inference (2008)

The alignment problem---establishing links between corresponding phrases in two related sentences---is as important in natural language inference (NLI) as it is in machine translation (MT). But the tools and techniques of MT alignment do not readily transfer to NLI, where one cannot assume semantic equivalence, and for which large volumes of bitext are lacking. We present a new NLI aligner, the MANLI system, designed to address these challenges. It uses a phrase-based alignment representation, exploits external lexical resources, and capitalizes on a new set of supervised training data. We compare the performance of MANLI to existing NLI and MT aligners on an NLI alignment task over the well-known Recognizing Textual Entailment data. We show that MANLI significantly outperforms existing aligners, achieving gains of 6.2% in F1 over a representative NLI aligner and 10.5% over GIZA++.
Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition (2012)

Despite nearly universal expression of the wild-type epidermal growth factor receptor (EGFR) and reproducible activity of EGFR inhibitors in patients with squamous cell carcinoma of the head and neck (SCCHN), the majority of patients will not have objective responses. The mechanisms of this intrinsic resistance are not well established. We hypothesized that sensitivity to EGFR inhibitors can be predicted based on the inhibitors' effects on downstream signaling. Cell viability assays were used to assess sensitivity to the EGFR inhibitor gefitinib (ZD1839) in 8 SCCHN cell lines. Fluorescence in-situ hybridization showed the two most sensitive lines to be highly gene-amplified for EGFR. Western blotting confirmed that phosphoEGFR was inhibited at low concentrations of gefitinib in all lines tested. Phosphorylation of downstream signaling protein AKT was inhibited in sensitive lines while inhibition of phosphoERK displayed no relationship to gefitinib efficacy. Phosphatase and tensin homolog (PTEN) expression was evident in all cell lines. Activating PIK3CA mutations were found in two resistant cell lines where pAKT was not inhibited by gefitinib. In resistant cell lines harboring PIK3CA mutations, a PI3K inhibitor, LY294002, or AKT siRNA reduced cell viability with an additive effect demonstrated in combination with gefitinib. Additionally, LY294002 alone and in combination with gefitinib, was effective at treating PIK3CA mutated tumors xenografted into nude mice. Taken together this suggests that constitutively active AKT is a mechanism of intrinsic gefitinib resistance in SCCHN. This resistance can be overcome through targeting of the PI3K/AKT pathway in combination with EGFR inhibition.
Maximum likelihood angle and velocity estimation with space-time adaptive processing radar (2002)

Airborne surveillance radar performance can be improved with space-time adaptive processing (STAP) to cancel ground clutter and interference. This paper considers maximum likelihood (ML) angle and velocity estimation for airborne radar employing STAP. The ML estimator requires a two-dimensional optimization. A computationally efficient quasi-Newton approach is proposed, whereby a positive definite approximate Hessian is formed using only the secondary data processed by three adaptive space-time filters. The algorithm is naturally initialized by the target detection location within a coarsely spaced angle-Doppler filter bank. Monte-Carlo simulations show that the new algorithm nearly achieves the Cramer-Rao bound and outperforms conventional one-dimensional estimators, which suffer from location-dependent biases when employed in STAP scenarios.
Sociodemografía del suicidio en la población adolescente y joven en Argentina, 1999-2007 (2011)

INTRODUCTION: Suicide is the fourth leading cause of death for people aged 15-24 in Argentina. At these early ages, this phenomenon is particularly tragic due to the loss of a young life, the enormous emotional impact on the environment and the potential years of life lost. OBJECTIVE: To explore some socio-demographic aspects (gender and place of residence) of suicide among adolescents (aged 15-19) and young adults (aged 20-24) in Argentina during 1999-2007. METHODS: Data on suicide deaths were obtained from vital statistics of the Argentine Ministry of Health by age, gender and place of residence. Population estimates and projections were those published by the Statistics and Census National Institute (INDEC). Rates of suicide among adolescents and young adults were analyzed for the whole period and according to gender, province and region by three-year periods. RESULTS: The average rate of suicide among people aged 15 to 24 resulted in 10.7 per 100,000 inhabitants (9.7 in adolescents and 11.7 in young adults). In Patagonia, the rates were higher than in the rest of the country. There was an inverse epidemiologic relationship: the lower the population density, the higher the suicide rates. CONCLUSIONS: The population group most at risk is young people. The risk of suicide increases as population density and service coverage get lower.
Fast Recovery from Link Failures and Blackout of a Managed Wireless Mesh for NerveNet (2010)

A managed wireless mesh for infrastructure-level, stable regional mesh network has been studied. NerveNet, which we have been proposing, is a concept of future regional platform network that covers local regions and provides various context-aware services with the shared use of sensors and actuators. The managed wireless mesh developed for materializing NerveNet features auto-configuration of multiple, different routes between any two base stations for high capacity and reliability. The managed wireless mesh of ten base stations was implemented on PCs and commercial L2 switches. Performance evaluation showed that route switching after one or two link failures had been detected was completed in no later than 70 milliseconds while it takes a few to tens of seconds with existing adhoc routing-based mesh networks. It was also shown that the restart of the network took only about three minutes, enabling urgent recovery of communication in emergency situations.
Multiple Input Digital Arbiter with Timestamp Assignment for Asynchronous Sensor Arrays (2006)

This paper introduces a novel concept for arbitrating the access of multiple asynchronous data sources to a shared communication bus, while adding a timestamp, which represents high precision temporal information, to sensor information. This principle is based upon an arbiter serving uncorrelated inputs and generating a stream of data packets. The information contained in the data packets consists of the address information identifying the data source, data from the source and a timestamp value with respect to the occurrence of the bus request (event) generated by the corresponding data source. To enhance the adaptability to particular applications, the time resolution can be varied. The proposed concept has the advantage of delivering a sorted output data stream of nearly concurrent events (labeled with the same timestamp) which is very advantageous for consecutive data processing. Furthermore, this arbitration method is very efficient as it enables the utilization of the maximum output transfer rate for a given clock frequency. A potential usage in asynchronous vision chips is intended. This concept is demonstrated using an asynchronous vision chip containing 512 autonomous optical sensor elements.
Austrian children living on a farm have less hay fever, asthma and allergic sensitization (2000)

Possible explanations for the lower prevalence of hay fever, asthma and allergic sensitization in children living on a farm might be the development of immunotolerance or the stimulation of TH1 cells and suppression of TH2 cells by increased exposure of farm children to microbial antigens in the stables or farmhouses.
Voice Over IP (1999)

Uyless Black has written the essential guide for telecommunications professionals who must understand voice-over-IP (VoIP)-or deploy it. Clearheaded and free of hype, Voice Over IP carefully evaluates both VoIP's challenges and its compelling advantages, and then reviews each technical standard and critical issue associated with successful deployment. Black describes today's best approaches for managing performance in both private and public IP networks, compares VoIP with packet voice alternatives such as Voice over Frame Relay (VoFR) and Voice over ATM (VoATM), and more. You'll also find convenient references to telephony signaling, ISDN and SS7, and V.90 modems. Every telecommunications professional will be impacted by the VoIP revolution. Whether you're evaluating or deploying VoIP, Voice Over IP places a world-class telecom consultant at your side, delivering all the objective information and insight you need to succeed.
Selective Effects of Subarachnoid Hemorrhage on Cerebral Vascular Responses to 4-Aminopyridine in Rats (2000)

These data suggest that 4-AP induces cerebral vasoconstriction in vivo through smooth muscle depolarization due to inhibition of voltage-dependent K(+) channels. Furthermore, function of these K(+) channels may be selectively reduced in the basilar artery after SAH and thus could contribute to cerebral vascular dysfunction.
COOL: An object-based language for parallel programming (1994)

Effectively using shared-memory multiprocessors requires substantial programming effort. We present the programming language COOL (Concurrent Object-Oriented Language), which was designed to exploit coarse-grained parallelism at the task level in shared-memory multiprocessors. COOL's primary design goals are efficiency and expressiveness. By efficiency we mean that the language constructs should be efficient to implement and a program should not have to pay for features it does not use. By expressiveness, we imply that the program should flexibly support different concurrency patterns, thereby allowing various decompositions of a problem. COOL emphasizes the integration of concurrency and synchronization with data abstraction to ease the task of creating modular and efficient parallel programs. It is an extension of C++, which was chosen because it supports abstract data type definitions and is widely used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Advanced Multifunctional MMOD Shield: Radiation Shielding Assessment (2013)

As NASA is looking to explore further into deep space, multifunctional materials are a necessity for decreasing complexity and mass. One area where multifunctional materials could be extremely beneficial is in the micrometeoroid orbital debris (MMOD) shield. A typical MMOD shield on the International Space Station (ISS) is a stuffed whipple shield consisting of multiple layers. One of those layers is the thermal blanket, or multi-layer insulation (MLI). Increasing the MMOD effectiveness of MLI blankets, while still preserving their thermal capabilities, could allow for a less massive MMOD shield. Thus, a study was conducted to evaluate a concept MLI blanket for an MMOD shield. In conjunction, this MLI blanket and the subsequent MMOD shield was also evaluated for its radiation shielding effectiveness towards protecting crew. The overall MMOD shielding system using the concept MLI blanket proved to only have a marginal increase in the radiation mitigating properties. Therefore, subsequent analysis was performed on various conceptual MMOD shields to determine the combination of materials that may prove superior for radiation mitigating purposes. The following paper outlines the evaluations performed and discusses the results and conclusions of this evaluation for radiation shielding effectiveness.
Etude des possibilités d’utilisation du sarcome TG 180 de la Souris. Application à la Toxoplasmose (1969)

Les différents protocoles qui permettent une abondante multiplication des toxoplasmes sont rappelés, en utilisant la cellule du sarcome T.G. 180.
3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (1973)

Abstract 3-Hydroxy-3-methylglutaryl coenzyme A reductase, the rate-controlling enzyme of cholesterol biosynthesis in rat liver, has been solubilized and purified 130-fold from rat liver microsomes. Evidence is presented to suggest that the enzyme is localized to the surface of the microsomal membrane. 3-Hydroxy-3-methylglutaryl-CoA reductase can be removed from microsomes by mild treatments such as exposure to high salt or glycerol concentrations which leave the bi-laminar structure of the microsomal membrane intact. The solubilized enzyme is rapidly inactivated by chilling to 4° and is protected from this cold-induced inactivation by salt only at concentrations in the range of 4 m. 3-Hydroxy-3-methylglutaryl-CoA reductase is the first solubilized microsomal enzyme reported to be cold-sensitive.
Purification of a Galactosyl-α1-4-galactose-binding Adhesin from the Gram-positive Meningitis-associated Bacterium Streptococcus suis (1995)

Streptococcus suis causes meningitis, sepsis, and other serious infections in newborn and young pigs and in adult humans. The Gal alpha 1-4Gal-binding adhesin of S. suis was purified to homogeneity by ultrasonic treatment, fractional ammonium sulfate precipitation, and preparative polyacrylamide gel electrophoresis. Pigeon ovomucoid, a glycoprotein with Gal alpha 1-4Gal terminals, was used to detect the adhesin by blotting. The purified adhesin appeared as single band of an apparent size of 18 kDa and of a pI of 6.4; no disulfide bridges were present. The amount of adhesin as revealed by pigeon ovomucoid binding correlated with the hemagglutination activity of different S. suis strains. The purified adhesin bound to latex particles induced hemagglutination which was specifically inhibited with the same inhibitors as hemagglutination by the intact bacteria, thus demonstrating that the purified protein was the Gal alpha 1-4Gal-recognizing adhesin of S. suis. Two adhesin variants (PN and PO) with differing Gal alpha 1-4Gal binding specificity had the similar electrophoretic mobilities and the same N-terminal peptide sequences, indicating that they were closely related. This represents the first isolation of an adhesin with well-defined cell surface carbohydrate binding activity from Gram-positive bacteria associated with meningitis.
Tumour phospholipid metabolism (1999)

Following the impetus of early clinical and experimental investigations, in vivo and in vitro MRS studies of tumours pointed in the eighties to the possible significance of signals arising from phospholipid (PL) precursors and catabolites as novel biochemical indicators of in vivo tumour progression and response to therapy. In the present decade, MRS analyses of individual components contributing to the 31P PME (phosphomonoester) and PDE (phosphodiester) resonances, as well as to the 1H 'choline peak', have reinforced some of these expectations. Moreover, the absolute quantification of these signals provided the basis for addressing more specific (although still open) questions on the biochemical mechanisms responsible for the formation of intracellular pools of PL derivatives in tumours, under different conditions of cell proliferative status and/or malignancy level. This article is aimed at providing an overview on: (a) quantitative MRS measurements on the contents of phosphocholine (PCho), phosphoethanolamine (PEtn) and their glycerol derivatives ģlycerol 3-phosphocholine (GPC) and glycerol 3-phosphoethanolamine (GPE)[ in human tumours and cells (with particular attention to breast and brain cancer and lymphomas), as well as in normal mammalian tissues (including developing organs and rapidly proliferating tissues); (b) possible correlations of MRS parameters like PEtn/PCho and PCho/GPC ratios with in vitro cell growth status and/or cell tumorigenicity; and (c) current and new hypotheses on the role and interplay of biosynthetic and catabolic pathways of the choline and ethanolamine cycles in modulating the intracellular sizes of PCho and PEtn pools, either in response to mitogenic stimuli or in relation to malignant transformation.
Overexpression of the Wilms' tumor gene <i>WT1</i> in colorectal adenocarcinoma (2003)

Expression of the Wilms' tumor gene WT1 was examined in 59 cases of colorectal adenocarcinoma to examine the involvement of WT1 in tumorigenesis. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) showed that WT1 mRNA was expressed in the range from 7.2 x 10(-5) to 4.9 x 10(-1) levels (WT1 expression level in K562 leukemic cells was defined as 1.0) in all (100%) of the 28 cases of colorectal adenocarcinoma examined, and that the WT1 mRNA expression levels were higher in 20 (71%) of the 28 cases compared to those of normal-appearing mucosal tissues examined. Immunohistochemical analysis using an anti-WT1 antibody was performed on 46 cases of colorectal adenocarcinoma (15 of the 28 cases with WT1 mRNA expression and 31 newly collected cases), and the expression of WT1 protein was detected in 41 (89%) of the 46 cases. The direct sequencing analysis of the WT1 genomic DNA showed no mutations in any of the 10 exons of the WT1 gene in any of 5 different colorectal adenocarcinomas. These results may indicate an important role of the wild-type WT1 gene in tumorigenesis of colorectal adenocarcinoma.
Central and Peripheral Administration of Antisense Oligonucleotide Targeting Amyloid-β Protein Precursor Improves Learning and Memory and Reduces Neuroinflammatory Cytokines in Tg2576 (AβPPswe) Mice (2014)

Alzheimer's disease (AD) is a progressive neurodegenerative disease. Currently, there are no therapies to stop or reverse the symptoms of AD. We have developed an antisense oligonucleotide (OL-1) against the amyloid-β protein precursor (AβPP) that can decrease AβPP expression and amyloid-β protein (Aβ) production. This antisense rapidly crosses the blood-brain barrier, reverses learning and memory impairments, reduces oxidative stress, and restores brain-to-blood efflux of Aβ in SAMP8 mice. Here, we examined the effects of this AβPP antisense in the Tg2576 mouse model of AD. We administered the OL-1 antisense into the lateral ventricle 3 times at 2week intervals. Seventy-two hours after the third injection, we tested learning and memory in T-maze foot shock avoidance. In the second study, we injected the mice with OL-1 antisense 3 times at 2-week intervals via the tail vein. Seventy-two hours later, we tested learning and memory T-maze, novel object recognition, and elevated plus maze. At the end of behavioral testing, brain tissue was collected. OL-1 antisense administered centrally improved acquisition and retention of T-maze foot shock avoidance. OL-1 antisense administered via tail vein improved learning and memory in both T-maze foot shock avoidance and novel object-place recognition. In the elevated plus maze, the mice which received OL-1 antisense spent less time in the open arms and had fewer entries into the open arms indicating reduced disinhibitation. Biochemical analyses reveal significant reduction of AβPP signal and a reduction of measures of neuroinflammation. The current findings support the therapeutic potential of OL-1 AβPP antisense.
Cerebral Amyloid Angiopathy: A Common Cause of Cerebral Hemorrhage (2009)

Amyloid is a term used to describe protein deposits with circumscript physical characteristics: beta-pleated sheet configuration, apple green birefringence under polarized light after Congo red staining, fibrillary structure and high insolubility. Cerebral amyloid angiopathy (CAA) defines a clinicopathological phenomenon characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and, less often capillaries and veins of the central nervous system. CAAs are currently classified according to the protein deposited including amyloid beta peptide (Abeta), cystatin C (ACys C), prion protein (PrP(Sc)), ABri/ADan, transthyretin (ATTR), and gelsolin (AGel). Most often amyloid deposition occurs in sporadic forms. In less common hereditary forms, a mutated variant protein or precursor protein is abnormally metabolized by proteolytic pathways in consequence of specific gene mutations, and accumulates as amyloid. The spectrum of clinical phenotypes associated with CAA-related vasculopathic changes includes both ischemic and hemorrhagic presentations, primary intracerebral hemorrhage (PICH) being probably the most well-recognized. However, in spite of accumulating data and recent progress in understanding the pathogenesis of CAA-related hemorrhage, the exact mechanisms leading to vessel rupture in these cases are yet to be established. This represents, at present, a major limitation to the identification of reliable biomarkers and the development of disease-specific treatment options. The present paper summarizes epidemiologic and clinical aspects of CAA, and highlights the presumed pathomechanisms of amyloid deposition in both sporadic and hereditary forms.