gebhart/patrepeval huggingface dataset:
Development of a Human Head Physical Surrogate Model for Investigating Blast Injury (2009)

The objective of this effort was to develop a Human Surrogate Head Model (HSHM) and measure its response to pressure loading conditions representative of a blast environment. The HSHM consists of skin, face, skull, and brain fabricated using biosimulant materials and mounted to the neck of a Hybrid III Anthropomorphic Test Device to allow head motion during loading. The HSHM instrumentation includes pressure and displacement sensors embedded in the anterior and posterior areas of the brain along the saggital plane. The displacement sensors are a custom solution developed for this particular application. A series of shock tube tests at three varying load levels were conducted with the HSHM to simulate blast loading conditions. As pressure loading levels increased, the intracranial pressures and brain displacements increased as well. However, the spatial response of the displacement sensors varied with location in the brain. The results of this test series provide the first instance of intracranial pressure and directly measured brain displacements recorded from an anatomically correct head surrogate exposed to conditions representative of blast loading.
Identification of differentially expressed genes and false discovery rate in microarray studies (2007)

There is growing consensus on how to analyse microarray data using the false discovery rate framework in place of the classical P value. Further research is needed on the preprocessing of the raw data, such as the normalization step and filtering, and on finding the most sensitive test procedure.
A new synthetic TLR4 agonist, GLA, allows dendritic cells targeted with antigen to elicit Th1 T‐cell immunity in vivo (2011)

Protein-based vaccines offer safety and cost advantages but require adjuvants to induce immunity. Here we examined the adjuvant capacity of glucopyranosyl lipid A (GLA), a new synthetic non-toxic analogue of lipopolysaccharide. In mice, in comparison with non-formulated LPS and monophosphoryl lipid A, formulated GLA induced higher antibody titers and generated Type 1 T-cell responses to HIV gag-p24 protein in spleen and lymph nodes, which was dependent on TLR4 expression. Immunization was greatly improved by targeting HIV gag p24 to DCs with an antibody to DEC-205, a DC receptor for antigen uptake and processing. Subcutaneous immunization induced antigen-specific T-cell responses in the intestinal lamina propria. Immunity did not develop in mice transiently depleted of DCs. To understand how GLA works, we studied DCs directly from vaccinated mice. Within 4 h, GLA caused DCs to upregulate CD86 and CD40 and produce cytokines including IL-12p70 in vivo. Importantly, DCs removed from mice 4 h after vaccination became immunogenic, capable of inducing T-cell immunity upon injection into naïve mice. These data indicate that a synthetic and clinically feasible TLR4 agonist rapidly stimulates full maturation of DCs in vivo, allowing for adaptive immunity to develop many weeks to months later.
Filtering and Mining Parallel Data in a Joint Multilingual Space (2018)

We learn a joint multilingual sentence embedding and use the distance between sentences in different languages to filter noisy parallel data and to mine for parallel data in large news collections. We are able to improve a competitive baseline on the WMT'14 English to German task by 0.3 BLEU by filtering out 25% of the training data. The same approach is used to mine additional bitexts for the WMT'14 system and to obtain competitive results on the BUCC shared task to identify parallel sentences in comparable corpora.
Fluid Attenuated Inversion Recovery (FLAIR) Imaging of the Normal Brain: Comparisons between Under the Conditions of 3.0 Tesla and 1.5 Tesla (2009)

We have demonstrated that normal, high and low SIs of the CS, PT and IDS on 3.0T FLAIR images were depicted more frequently and more prominently as compared with those on 1.5T FLAIR images in normal adult brains.
A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation (1994)

Amyloid deposits are associated with a variety of amyloid diseases, although their role in the pathogenesis remains unclear. Detection of amyloid fibrils and/or prevention of their formation appears to be important in the diagnosis and treatment of amyloid diseases such as Alzheimer's disease. The design of therapeutic molecules with this activity requires a detailed understanding of the structure of the amyloid fibril and the mechanism of fibril formation. This review is focused on studies carried out in the laboratories of the authors, who were trained as organic chemists and bring that perspective to their work. The ongoing studies described within have as their ultimate goal the complete description of the molecular mechanism of amyloid formation by two proteins; transthyretin and the amyloid protein. The purpose of this review is to outline chemical approaches and methodology which prove to be useful for understanding amyloid fibril formation.
Photophysics of donor-acceptor substituted stilbenes. A time-resolved fluorescence study using selectively bridged dimethylamino cyano model compounds (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotophysics of donor-acceptor substituted stilbenes. A time-resolved fluorescence study using selectively bridged dimethylamino cyano model compoundsRene Lapouyade, Konstantin Czeschka, Wilfried Majenz, Wolfgang Rettig, Eric Gilabert, and Claude RulliereCite this: J. Phys. Chem. 1992, 96, 24, 9643–9650Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/j100203a016https://doi.org/10.1021/j100203a016research-articleACS PublicationsRequest reuse permissionsArticle Views870Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Hot flashes are associated with increased ambulatory systolic blood pressure (2007)

Hot flashes are associated with increased awake and sleep systolic BP independent of menopausal status. Further investigation is warranted to elucidate the mechanisms by which hot flashes are associated with BP.
Volatility of UO <sub>2±x</sub> and Phase Relations in the System Uranium—Oxygen (1964)

The volatility of UO 2±x and the phase relations in the system uranium‐oxygen were studied using thermogravimetric techniques. Chemical reactions describing the loss of uranium from UO 2±x at temperatures between 1100° and 2200°C in oxygen pressures between approximately 10 2 and 10 −6 torr are proposed. Results were obtained requiring the consideration of UO 4 (g) as the uranium‐bearing vapor species above UO 2±x . Evidence supporting the existence of UO 4 (g) included the volatilization of material with an oxygen‐to‐uranium ratio of 4 during the decomposition of UO 2+x (0.Z > × > 0) to near‐stoichiometric UO 2 in vacuum above 1500°C and the dependence of the evaporation rate of the uranium dioxide on the oxygen pressure between 1200° and 1500°C. The equilibrium oxygen pressures over compositions between UO 2.02 and UO 2.63 in the UO 2+x and U 3 O 8‐y regions and over the boundary between these phases were measured between 1000° and 1600°C. The equilibrium oxygen‐to‐uranium ratio of UO 2±x was less than 2 above 1700°C in vacuum.
<title>SIRSALE: integrated video database management tools</title> (2002)

Video databases became an active field of research during the last decade. The main objective in such systems is to provide users with capabilities to friendly search, access and playback distributed stored video data in the same way as they do for traditional distributed databases. Hence, such systems need to deal with hard issues : (a) video documents generate huge volumes of data and are time sensitive (streams must be delivered at a specific bitrate), (b) contents of video data are very hard to be automatically extracted and need to be humanly annotated. To cope with these issues, many approaches have been proposed in the literature including data models, query languages, video indexing etc. In this paper, we present SIRSALE : a set of video databases management tools that allow users to manipulate video documents and streams stored in large distributed repositories. All the proposed tools are based on generic models that can be customized for specific applications using ad-hoc adaptation modules. More precisely, SIRSALE allows users to : (a) browse video documents by structures (sequences, scenes, shots) and (b) query the video database content by using a graphical tool, adapted to the nature of the target video documents. This paper also presents an annotating interface which allows archivists to describe the content of video documents. All these tools are coupled to a video player integrating remote VCR functionalities and are based on active network technology. So, we present how dedicated active services allow an optimized video transport for video streams (with Tamanoir active nodes). We then describe experiments of using SIRSALE on an archive of news video and soccer matches. The system has been demonstrated to professionals with a positive feedback. Finally, we discuss open issues and present some perspectives.
Anti-rhodopsin antibodies in sera from patients with normal-pressure glaucoma. (1995)

An elevated anti-rhodopsin antibody count is related to NPG. This may indicate that there is an autoimmune component in the optic neuropathy in these patients. The specific role of these autoantibodies, if any, in the pathogenesis of the disease remains to be determined.
Expression of Concern: Robust automated synthesis methodology for integrated spiral inductors with variability (2005)

In order to synthesize spiral inductor designs to meet stringent design requirements, fundamental trade-offs in the design space must be analyzed and exploited. In this paper, we develop a robust automated synthesis methodology to efficiently generate spiral inductor designs using multi-objective optimization techniques and surrogate functions to approximate Pareto surfaces in the design space. Using our synthesis methodology, we also demonstrate how to reduce the impact of process variation and other sources of modeling error on spiral inductors. Our results indicate that our synthesis methodology efficiently optimizes inductor designs based on the application's design requirements with an improvement of up to 51% in key inductor design constraints while reducing the impact of process and model variations.
Kleine Kohlenstoff‐Ringe I Über den Mechanismus der Butadien‐Dimerisation zum Achtring (1958)

Abstract Für die thermische, nichtkatalysierte Dimerisation des Butadiens zum cis‐cis ‐Cyclooctadien‐(1.5), die bislang als eine 1.4–1.4‐Addition formuliert wurde, wird ein neuer Reaktionsmechanismus vorgeschlagen. Danach erfolgt die Bildung des Achtrings über eine intermediäre 1.2–1.2‐Addition des Butadiens zu einem Cyclobutanderivat, dem noch unbekannten cis ‐1.2‐Divinylcyclobutan, das sich bereits unter den Reaktionsbedingungen in cis‐cis ‐Cyclooctadien‐(1.5) umlagert. Um diesen Mechanismus der Butadien‐Dimerisation zum Achtring experimentell zu untermauern, wurde der als Zwischenprodukt angenommene Vierring‐Kohlenwasserstoff auf einem unabhängigen Wege synthetisiert und sein thermisches Verhalten untersucht. cis ‐1.2‐Divinylcyclobutan ist, wie erwartet, eine sehr instabile Verbindung und isomerisiert sich schon beim Erhitzen auf 120° spontan zum cis‐cis ‐Cyclooctadien‐(1.5).
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer (2019)

Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant ± ribociclib or palbociclib. This resistance was abrogated by treatment with the FGFR tyrosine kinase inhibitor (TKI) lucitanib. Addition of the FGFR TKI erdafitinib to palbociclib/fulvestrant induced complete responses of FGFR1-amplified/ER+ patient-derived-xenografts. Next generation sequencing of circulating tumor DNA (ctDNA) in 34 patients after progression on CDK4/6 inhibitors identified FGFR1/2 amplification or activating mutations in 14/34 (41%) post-progression specimens. Finally, ctDNA from patients enrolled in MONALEESA-2, the registration trial of ribociclib, showed that patients with FGFR1 amplification exhibited a shorter progression-free survival compared to patients with wild type FGFR1. Thus, we propose breast cancers with FGFR pathway alterations should be considered for trials using combinations of ER, CDK4/6 and FGFR antagonists.
A framework for differential frame-based matching algorithms in input-queued switches (2005)

We propose a novel framework to solve the problem of scheduling packets in high-speed input-queued switches with frame-based control. Our approach is based on the application of game theory concepts. We define a flexible scheduling policy, named SSB (slot sell and buy): the existence of a unique Nash equilibrium for the policy is proved, together with properties of convergence of these equilibria. These findings allows us to state that our SSB scheduling policy achieves 100% throughput both in isolated input-queued switches arid in networks of input-queued switches. Simulation results are used to further validate the approach and to show its flexibility in dealing with differentiated QoS guarantees.
A Configurable and Low-Power Mixed Signal SoC for Portable ECG Monitoring Applications (2013)

This paper describes a mixed-signal ECG System-on-Chip (SoC) that is capable of implementing configurable functionality with low-power consumption for portable ECG monitoring applications. A low-voltage and high performance analog front-end extracts 3-channel ECG signals and single channel electrode-tissue-impedance (ETI) measurement with high signal quality. This can be used to evaluate the quality of the ECG measurement and to filter motion artifacts. A custom digital signal processor consisting of 4-way SIMD processor provides the configurability and advanced functionality like motion artifact removal and R peak detection. A built-in 12-bit analog-to-digital converter (ADC) is capable of adaptive sampling achieving a compression ratio of up to 7, and loop buffer integration reduces the power consumption for on-chip memory access. The SoC is implemented in 0.18 μm CMOS process and consumes 32 μ W from a 1.2 V while heart beat detection application is running, and integrated in a wireless ECG monitoring system with Bluetooth protocol. Thanks to the ECG SoC, the overall system power consumption can be reduced significantly.
Traveler's Diarrhea at Sea: Three Outbreaks of Waterborne Enterotoxigenic<i>Escherichia coli</i>on Cruise Ships (2000)

Enterotoxigenic Escherichia coli (ETEC) has become the leading bacterial cause of gastroenteritis outbreaks on cruise ships. Investigation of recent outbreaks of ETEC gastroenteritis on 3 cruise ships indicated that all were associated with consuming beverages with ice cubes on board the ship (relative risk [RR], 1.4, 95% confidence interval [CI], 1.0-1.9, P=.02; RR, 1.9, 95% CI, 1.3-2. 9, P<.001; and RR, 1.3, 95% CI, 1.0-1.6, P<.01), and 2 were associated with drinking unbottled water (RR, 2.7, 95% CI, 1.8-4.1, P<.001; RR, 1.7, 95% CI, 1.3-2.3, P<.001). Multiple ETEC serotypes were detected in patients' stool specimens in each of the 3 outbreaks, and 12 (38%) of 32 isolates were resistant to > or =3 antimicrobial agents. ETEC appears to be emerging as a waterborne pathogen on cruise ships. Water bunkered in overseas ports was the likely source of ETEC infection in these outbreaks. To ensure passenger safety, cruise ships that take on water in foreign ports must ensure that water treatment and monitoring systems function properly.
Glutamine Starvation of Murine Leukaemia Virus-infected Cells Inhibits the Readthrough of the gag-pol Genes and Proteolytic Processing of the gag Polyprotein (1986)

The production of Moloney murine leukaemia virus from chronically infected cells was inhibited after starvation of glutamine. While the rate of synthesis of the precursor of the core proteins, Pr65gag, was not affected in the starved cells, its proteolytic processing was blocked. Pulse-chase experiments indicated that glutamine was required during the synthesis of Pr65gag to facilitate its subsequent processing. In addition, the synthesis of Pr200gag-pol, the precursor of the protease, reverse transcriptase and endonuclease, was inhibited in the glutamine-starved cells. Starvation for other essential amino acids such as tyrosine and isoleucine affected neither the synthesis nor the processing of the virus proteins. These results suggest that the readthrough mechanism which enables synthesis of the Pr200gag-pol polyprotein is modulated in the chronically infected cells by glutamine levels. Since the viral protease is part of the pol gene, its synthesis may be inhibited in the glutamine-starved cells and Pr65gag is therefore not processed.
Stability of Butadiene Polyperoxide (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStability of Butadiene PolyperoxideD. G. Hendry, F. R. Mayo, D. A. Jones, and Dennis SchuetzleCite this: Ind. Eng. Chem. Prod. Res. Dev. 1968, 7, 2, 145–151Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/i360026a011https://doi.org/10.1021/i360026a011research-articleACS PublicationsRequest reuse permissionsArticle Views294Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A clinical comparison of subdural screw pressure measurements with ventricular pressure (1983)

Simultaneous recordings of intracranial pressure (ICP) from a single-lumen subdural screw and a ventricular catheter were compared in 10 patients with severe head injury. Forty-one percent of the readings corresponded within the same 10 mm Hg ranges, while 13% of the screw pressure measurements were higher and 46% were lower than the associated ventricular catheter measurements. In 10 other patients, also with severe head injury, pressure measurements obtained with the Leeds-type screw were similarly compared with ventricular fluid pressure. Fifty-eight percent of the dual pressure readings corresponded, while 15% of the screw measurements were higher and 27% were lower than the ventricular fluid pressure, within 10-mm Hg ranges. It is concluded that subdural screws may give unreliable results, particularly by underestimating the occurrence of high ICP.
Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray (2003)

Gene expression analysis comparing nonpregnant with pregnant bovine uteri, including placenta, was performed with a custom cDNA microarray containing 1,933 independent genes. These genes were classified into six categories according to biological function, as follows: cell and tissue structural dynamics (108 genes), intercellular communication (221), intracellular metabolism (265), cell cycle and apoptosis (26), regulation of gene expression (113), expressed sequence tag (EST) and function unknown (617), and uncomplemented genes (583 clones). This array possessed bovine placental/endometrial specificity, as it included many pregnancy-specific molecules, such as pregnancy-associated glycoprotein-1 (PAGs), placental lactogen (PLs), and prolactin-related protein-1 (PRPs). A total of 77 genes were induced and 12 repressed in the placenta/endometrium. Our results point to a fundamental role for bovine placental-specific genes such as PAGs, PLs, and PRPs, in implantation and placentogenesis, and document that cDNA microarray analysis from bovine placenta/endometrium is possible and is a specific tool for monitoring genome-wide gene expression during the establishment and maintenance of pregnancy.
Taking<i>Born to Rebel</i>Seriously: The Need for Independent Review (2000)

My thanks to the commentators for their thoughtful analyses. I will respond to their comments below. I should point out that under the format for this roundtable discussion, I have not yet seen Frank Sulloway's response to my article. Any reply I might have to his response will therefore have to come later.
The role of extracellular signal-regulated protein kinase in transcriptional regulation of the hypoxia marker carbonic anhydrase IX (2005)

In the present study, we investigated the role of the extracellular signal-regulated protein kinase (ERK) in regulation of the hypoxia marker, carbonic anhydrase IX (CAIX). U0126, a specific inhibitor of MEK1/2, downregulated CAIX expression induced by true hypoxia and cell density. CA9 promoter activity was similarly affected. Mapping of the U0126 effect revealed that both critical elements within the CA9 promoter, the hypoxia response element and the juxtaposed SP1-binding PR1, were inhibited. This confirmed that ERK signaling modulates CA9 promoter activity via its effects on hypoxia inducible factor-1 (HIF-1) and SP1. Further analysis of the U0126 effect on HIF-1-dependent transcription in MCF-7 cells identified p300, a transcriptional co-activator of HIF-1, as the target of ERK. Constitutively increased ERK activity in isogenic fibrosarcoma cell lines did not cause increased cell density-dependent CAIX expression/CA9 promoter activity. In HeLa cells, an inverse correlation between cell density-induced CAIX expression and ERK activation was observed: sparse cultures did not express CAIX and displayed high ERK activation, whereas CAIX expression in dense cultures was associated with low ERK activation. Collectively, our data do not support any quantitative relationship between ERK activation and CAIX expression. Thus, although ERK signaling is required for optimal CAIX expression, our data are consistent with a model in which constitutive basal ERK activity plays an auxiliary role in CA9 promoter transactivation by modulating activity of the transcription factor SP1 and the transcriptional co-activator p300.