gebhart/patrepeval huggingface dataset:
Cell-Mediated Immune Response to Human Immunodeficiency Virus (HIV) Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1 (1992)

Although human immunodeficiency virus (HIV) type 1 infection is efficiently transmitted by sexual intercourse, some individuals whose sexual behavior places them at extremely high risk for infection have nevertheless remained HIV-1-seronegative. An investigation was undertaken to determine whether such individuals have circulating T helper cells that are sensitized to HIV-1. Five very high risk men who had recent sexual exposure to HIV-1 were studied. Peripheral blood mononuclear cells from all 5 produced interleukin (IL)-2 in culture in response to synthetic amphipathic HIV-1 envelope peptides. One of the 5 high-risk men has subsequently seroconverted, while 4 have remained seronegative. All were initially culture-negative, and those who have remained seronegative were also virus-negative by polymerase chain reaction (PCR) testing 10 months after they were first studied. These results demonstrate that a cell-mediated immune response to HIV-1 can be detected in the absence of a humoral immune response in individuals recently exposed to HIV-1. Furthermore, IL-2 production by T cells in response to synthetic peptides may be a more sensitive test for exposure to HIV-1 than antibody, lymphoproliferation, or PCR tests.
Relationship Between Visual and Auditory Discrimination and Anxiety Level (1958)

(1958). Relationship Between Visual and Auditory Discrimination and Anxiety Level. The Journal of General Psychology: Vol. 59, No. 1, pp. 111-118.
Analysis of a switch matrix for an SS/TDMA system (1977)

Time slot scheduling problem for a satellite switched/time-division multiple access (SS/TDMA) system is discussed and an algorithm called Greedy Algorithm is presented. This algorithm guarantees a most efficient utilization of a frame period with n2- n (n is the number of beams) number of switchings at most. Another problem discussed in this paper is the choice of the type of microwave switch matrix to be put on board the satellite. A switch-matrix structure called rearrangeable multistage matrix is shown to have high reliability and low-insertion-loss characteristics. Also brief discussions are made on the experimental results of an engineering model SS/TDMA system.
Possible Pharmacotherapy of the Opioid κ Receptor Agonist for Drug Dependence (2004)

Because there are few efficacious medications for drug dependence, many clinical trials are being conducted in earnest to find such medications. Considerable evidence has shown that opioid kappa receptor agonists attenuate several behavioral responses induced by drugs of abuse. Although this raises the possibility that opioid kappa receptor agonists may be useful for the treatment of drug dependence on drugs of abuse, it has been previously reported that treatment with selective opioid kappa receptor agonists causes a psychotomimetic effect and dysphoria both in clinical studies and experimental animal models. As a result, we found the novel opioid kappa receptor agonist TRK-820, another chemical class of opioid kappa receptor agonist that has a morphinan scaffold unlike prototypical opioid kappa receptor agonists, by application of a modified message-address concept. TRK-820 showed high selectivity for an opioid kappa receptor, and strong agonistic activity in both in vitro and in vivo experiments. Like other opioid kappa receptor agonists, TRK-820 could markedly suppress the rewarding effects induced by morphine and cocaine and the discriminative stimulus effect of cocaine. Furthermore, TRK-820 attenuated the mecamylamine-precipitated nicotine-withdrawal aversion in a conditioned place preference paradigm. It is worthwhile to note that unlike prototypical opioid kappa receptor agonists, TRK-820 failed to produce a significant place aversion in rodents at doses that were sufficient to produce significant antinociception. Taken together, these findings indicate that TRK-820 may be useful for the treatment of drug dependence without any aversive effects.
Bioreactors for Removing Methyl Bromide following Contained Fumigations (2003)

Use of methyl bromide (MeBr) as a quarantine, commodity, or structural fumigant is under scrutiny because its release to the atmosphere contributes to the depletion of stratospheric ozone. A closed-system bioreactor consisting of 0.5 L of a growing culture of a previously described bacterium, strain IMB-1, removed MeBr (>110 μmol L-1) from recirculating air. Strain IMB-1 grew slowly to high cell densities in the bioreactor using MeBr as its sole carbon and energy source. Bacterial oxidation of MeBr produced CO2 and hydrobromic acid (HBr), which required continuous neutralization with NaOH for the system to operate effectively. Strain IMB-1 was capable of sustained oxidation of large amounts of MeBr (170 mmol in 46 d). In an open-system bioreactor (10-L fermenter), strain IMB-1 oxidized a continuous supply of MeBr (220 μmol L-1 in air). Growth was continuous, and 0.5 mol of MeBr was removed from the air supply in 14 d. The specific rate of MeBr oxidation was 7 × 10-16 mol cell-1 h-1. Bioreactors such as these can therefore be used to remove large quantities of contaminant MeBr, which opens the possibility of biodegradation as a practical means for its disposal.
A Class of Low Power Error Compensation Iterative Decoders (2011)

Recent power reduction techniques aggressively modulate the supply voltage of embedded buffering memories allowing acceptable hardware errors to flow through the processing chain. In this paper, we introduce a class of modified Turbo and LDPC decoders that provide significant improvements over standard decoders in the presence of hardware noise. Simulation results show a consistent improvement in the BER performance of the modified decoders across all SNRs with very small area and power overheads as compared to the conventional decoders.
Lipids of human meibum: mass-spectrometric analysis and structural elucidation (2007)

The purpose of this study was to structurally characterize the major lipid species present in human meibomian gland secretions (MGS) of individual subjects by means of ion trap atmospheric pressure ionization mass spectrometry analysis (API MS(n)). The samples of MGS and authentic lipid standards were analyzed in direct infusion and high-pressure liquid chromatography (HPLC) experiments with API MS(n) detection of the analytes (HPLC API MS(n)). The major precursor ions were isolated and subjected to further sequential fragmentation in MS(n) experiments, and their fragmentation patterns were compared with those of authentic lipid standards. Multiple precursor ions were observed in the positive-ion mode. Among those, previously identified cholesterol (Chl; m/z 369; [M - H(2)O + H](+)) and oleic acid (OA; m/z 283; [M + H](+)) were found. The other major compounds of the general molecular formula C(n)H(2n-2)O(2) were consistent with wax esters (WEs), with OA as fatty acyl component. Accompanying them were two homologous series of compounds that fit the molecular formulas C(n)H(2n-4)O(2) and C(n)H(2n)O(2). Subset 2 was found to be a homolog series of linoleic acid-based WEs, whereas subset 3 was, apparently, a mixture of stearic acid-based WEs. HPLC API MS(n) analysis revealed the presence of large quantities of cholesteryl esters (Chl-Es) in all of the tested samples. Less than 0.1% (w/w) of oleamide was detected in human MGS. In the negative-ion mode, three major compounds with m/z values of 729, 757, and 785 that were apparently related to anionogenic lipids of the diacylglyceryl family were found in all of the samples. Common phospholipids and ceramides (Cers) were not present among the major MGS lipids. Phosphocholine-based lipids were found in MGS in quantities less than 0.01% (w/w), if at all. This ratio is two orders of magnitude lower than reported previously. These observations suggest that MGS are a major source of nonpolar lipids of the WE and Chl-E families for the tear film lipid layer, but not of its previously reported (phospho)lipid, Cer, and fatty acid amide components.
Code construction and FPGA implementation of a low-error-floor multi-rate low-density Parity-check code decoder (2006)

With the superior error correction capability, low-density parity-check (LDPC) codes have initiated wide scale interests in satellite communication, wireless communication, and storage fields. In the past, various structures of single code-rate LDPC decoders have been reported. However, to cover a wide range of service requirements and diverse interference conditions in wireless applications, LDPC decoders that can operate at both high and low code rates are desirable. In this paper, a 9-k code length multi-rate LDPC decoder architecture is presented and implemented on a Xilinx field-programmable gate array device. Using pin selection, three operating modes, namely, the irregular 1/2 code mode, the regular 5/8 code mode, and the regular 7/8 code mode, are supported. Furthermore, to suppress the error floor level, a characterization on the conditions for short cycles in a LDPC code matrix expanded from a small base matrix is presented, and a cycle elimination algorithm is developed to detect and break such short cycles. The effectiveness of the cycle elimination algorithm has been verified by both simulation and hardware measurements, which show that the error floor is suppressed to a much lower level without incurring any performance penalty. The implemented decoder is tested in an experimental LDPC orthogonal frequency division multiplexing system and achieves the superior measured performance of block error rate below 10/sup -7/ at signal-to-noise ratio of 1.8 dB.
Third-Party Reimbursement for the Audiological Management of Patients Receiving Ototoxic Drugs (2006)

No AccessPerspectives on Hearing and Hearing Disorders: Research and DiagnosticsArticle1 Aug 2006Third-Party Reimbursement for the Audiological Management of Patients Receiving Ototoxic Drugs Steven C. White and Dawn Konrad-Martin Steven C. White Health Care Economics and Advocacy, ASHA Google Scholar More articles by this author and Dawn Konrad-Martin Veterans Affairs Rehabilitation Research and Development Service, National Center for Rehabilitative Auditory Research, VA Medical Center, Portland, OR Department of Otolaryngology, Oregon Health & Science UniversityPortland, OR Google Scholar More articles by this author https://doi.org/10.1044/hhd10.1.16 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "Third-Party Reimbursement for the Audiological Management of Patients Receiving Ototoxic Drugs." Perspectives on Hearing and Hearing Disorders: Research and Diagnostics, 10(1), pp. 16–17 References ASHA. (1994). Guidelines for the audiologic management of individuals receiving cochleotoxic drug therapy.ASHA, 36 (Suppl. 12), 11–19. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 10Issue 1August 2006Pages: 16-17 Get Permissions Add to your Mendeley library History Published in issue: Aug 1, 2006 Metrics Topicsasha-topicsleader-topicsasha-article-typesasha-sigsCopyright & Permissions© 2006 American Speech-Language-Hearing AssociationPDF DownloadLoading ...
Cloud Computing and Information Policy: Computing in a Policy Cloud? (2008)

ABSTRACT Cloud computing is a computing platform that resides in a large data center and is able to dynamically provide servers with the ability to address a wide range of needs, from scientific research to e-commerce. The provision of computing resources as if it were a utility such as electricity, while potentially revolutionary as a computing service, presents many major problems of information policy, including issues of privacy, security, reliability, access, and regulation. This article explores the nature and potential of cloud computing, the policy issues raised, and research questions related to cloud computing and policy. Ultimately, the policy issues raised by cloud computing are examined as a part of larger issues of public policy attempting to respond to rapid technological evolution.
Terahertz absorption spectrum of <i>para</i> and <i>ortho</i> water vapors at different humidities at room temperature (2006)

Terahertz time-domain spectroscopy has been used to measure the absorption of water vapor in 0.2–2.4THz range from low to high humidity at room temperature. The observed absorption lines are due to the water molecular rotations in the ground vibrational state. We find that the absorption strength of para transitions increases as humidity increases, while the absorption strength of ortho transitions increases and then decreases in intensity with increasing humidity. We explain this difference based on the nuclear spin statistics based ratio of ortho to para water monomer populations at room temperature. The preferential adsorption on the solid surfaces of para water leads to an ortho dominated vapor cloud whose monomer rotational absorption intensity decreases due to the effects of dimerization, molecular collisions, clustering, and interactions with liquid droplets at high concentrations.
Some new platinum acetylene complexes (1968)

D. M. Roundhill and H. B. Jonassen, Chem. Commun. (London), 1968, 1233b DOI: 10.1039/C1968001233B
A Novel B-cell Line (U-2932) Established from a Patient with Diffuse Large B-cell Lymphoma Following Hodgkin Lymphoma (2002)

Little is known about mechanisms leading to secondary non-Hodgkin lymphomas (NHL) in patients treated for Hodgkin lymphoma (HL). Our aim was to characterise in detail a cell line derived from a diffuse large B-cell lymphoma (DLBCL) that had developed in a patient with relapsing HL. The cell line U-2932 was established from ascites in a patient suffering from DLBCL previously treated for HL with multiple chemotherapy regimens. Characterisation was based on morphology, immunophenotype, Epstein-Barr virus (EBV)-status, IgH gene rearrangement status, tumourigenicity, p53 sequencing, and immunohistochemical expression of p53, BCL-2 and BCL-6. The karyotype was investigated using G-banding, comparative genomic hybridisation (CGH) and spectral karyotype (SKY) analysis. This cell line shows typical morphological features of a DLBCL and grows as colonies in nude mice. It expresses a B-cell phenotype with a somatically hypermutated V(H)4-39 gene and is negative for EBV. The origin of U-2932 was confirmed by demonstrating an identical V(H)4 rearrangement in ascites from the patient. A point mutation of the tumour-suppressor gene p53 was detected in amino acid position 176 and immunohistochemical over-expression of the p53 protein was also demonstrated. U-2932 carries a complex karyotype including high-level amplifications of the chromosomal bands 18q21 and 3q27 and expresses aberrant BCL-2 and BCL-6 immunohistochemically. We were unable to investigate the clonal relationship between the original HL and U-2932. In conclusion, U-2932 is a unique B cell line established from a patient suffering from HL followed by NHL. Overexpression of BCL-2, BCL-6 and p53 may play a role in the tumourigenesis and drug resistance. This cell line may become a useful tool to better understand the mechanisms responsible for development of secondary NHL in patients treated for HL.
Efficient optimal pagination of scrolls (1985)

Diehr and Faaland developed an algorithm that finds the minimum sum of key length pagination of a scroll of n items, and which uses O(n log n) time, solving a problem posed by McCreight. An improved algorithm is given which uses O(n) time.
Auto White Balance Using Chromatic Coordinates of Detected Human Faces (2008)

This paper proposes auto white balance algorithm for the picture that is taken for people. General white balance algorithms bring neutral region into focus. But, other objects can be basis if its spectral reflectance is known. In this paper the basis for white balance is human face. For experiment, first, transper characteristic of image sensor is analyzed and camera output RGB on average face chromaticity under standard illumination is caculated. Second, Output rate for the image is adjusted to make RGB rate for the face photo area taken under unknown ilumination RGB rate that is already caculated. Input tristimulus XYZ can be calculated from camera outpu RGB by camera transfer matrix. And input tristimulus XYZ is transformed to standard color space (sRGB) using sRGB transfer matrix. For display, RGB data is encoded as eight-bit data after gamma correction. Algorithm is applied to average face color that is light skin color of Macbeth color chart and average color of various face colors that are actually measured.
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene (2001)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Asymmetric Synthesis of α-Methyl α-Amino Acids through Diastereoselective Alkylation under Mild Reaction Conditions of an Iminic Alanine Template with a 1,2,3,6-Tetrahydro-2-pyrazinone Structure (2000)

(6R)-6-Isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone, obtained from (R)-valine and (S)-alanine, is highly diastereoselectively alkylated at room temperature by: a) activated alkyl halides under solid-liquid PTC conditions, b) non-activated alkyl halides with organic bases, c) electrophilic olefins employing both solid−liquid PTC conditions and organic bases, and d) allylic carbonates by means of palladium catalysis under neutral conditions. Enantiomerically pure (S)-α-methyl α-amino acids 8 are obtained by hydrolysis of the alkylated pyrazinones.
Long-Term Effects of Two Different Ventilatory Modes on Oxygenation in Acute Lung Injury. Comparison of Airway Pressure Release Ventilation and Volume-Controlled Inverse Ratio Ventilation (1994)

A total of 18 patients with acute lung injury (ALI) were sequentially ventilated with two different modes of mechanical ventilation, each applied for a period of 24 h: (1) volume-controlled inverse ratio ventilation (VC-IRV), (2) airway pressure release ventilation (APRV). The individual sequence of both ventilatory modes was randomized. Ventilatory minute volume was adjusted for a PaCO2 of 35 to 45 mm Hg at the beginning of the study during the first ventilatory mode and then kept constant within preset limits. Hemodynamic variables were stable and similar during the 24-h periods of VC-IRV and APRV as well. Despite the lower sedation and spontaneous breathing during APRV, oxygen uptake was similar during both ventilatory modes. During the 24-h period of VC-IRV there was no relevant change of either airway pressures, alveolo-arterial O2 tension difference (AaDO2)/fraction of inspired oxygen (FIO2) or venous admixture. In contrast, peak airway pressures (Pawmax) during APRV were significantly lower (about 30%; p < 0.01), and decreased further within 24 h (p < 0.05). During APRV AaDO2/FIO2 and venous admixture improved significantly with time after more than 8 h (AaDO2/FIO2: 487 versus 414 mm Hg; p < 0.01; venous admixture: 20.6 versus 13.9%; p < 0.01; medians of onset versus end). The improvement was significantly different between both ventilatory modes (p < 0.01). We conclude that this indicates a progressive alveolar recruitment over time during ventilation with APRV.(ABSTRACT TRUNCATED AT 250 WORDS)
Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells (2009)

Viruses that infect the lung are a significant cause of morbidity and mortality in animals and humans worldwide. Coronaviruses are being associated increasingly with severe diseases in the lower respiratory tract. Alveolar epithelial cells are an important target for coronavirus infection in the lung, and infected cells can initiate innate immune responses to viral infection. In this overview, we describe in vitro models of highly differentiated alveolar epithelial cells that are currently being used to study the innate immune response to coronavirus infection. We have shown that rat coronavirus infection of rat alveolar type I epithelial cells in vitro induces expression of CXC chemokines, which may recruit and activate neutrophils. Although neutrophils are recruited early in infection in several coronavirus models including rat coronavirus. However, their role in viral clearance and/or immune-mediated tissue damage is not understood. Primary cultures of differentiated alveolar epithelial cells will be useful for identifying the interactions between coronaviruses and alveolar epithelial cells that influence the innate immune responses to infection in the lung. Understanding the molecular details of these interactions will be critical for the design of effective strategies to prevent and treat coronavirus infections in the lung.
Distillating knowledge about SCOTCH (2009)

The design of the Scotch library for static mapping, graph partitioning and sparse matrix ordering is highly modular, so as to allow users and potential contributors to tweak it and add easily new static mapping, graph bipartitioning, vertex separation or graph ordering methods to match their particular needs. The purpose of this tutorial is twofold. It will start with a description of the interface of Scotch, presenting its visible objects and data structures. Then, we will step into the API mirror and have a look at the inside: the internal representation of graphs, mappings and orderings, and the basic sequential and parallel building blocks: graph induction, graph coarsening which can be re-used by third-party software. As an example, we will show how to add a simple genetic algorithm routine to the graph bipartitioning methods.
Log-time algorithms for scheduling single and multiple channel data broadcast (1997)

With the increasing popularity of portable wireless computers, mechanisms to efficiently transmit information to such clients are of significant interest. The environmentunderconsideration is asymmetric in that the information server has much more bandwidth available, as compared to the clients. It has been proposed that in such systems the server should broadcast the information periodically. A broadcastschedrale determines what is broadcast by the server and when.
Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy (2012)

Facioscapulohumeral muscular dystrophy (FSHD) is a common form of muscular dystrophy characterized by an asymmetric progressive weakness and wasting of the facial, shoulder and upper arm muscles, frequently accompanied by hearing loss and retinal vasculopathy. FSHD is an autosomal dominant disease linked to chromosome 4q35, but the causative gene remains controversial. DUX4 is a leading candidate gene as causative of FSHD. However, DUX4 expression is extremely low in FSHD muscle, and there is no DUX4 animal model that mirrors the pathology in human FSHD. Here, we show that the misexpression of very low levels of human DUX4 in zebrafish development recapitulates the phenotypes seen in human FSHD patients. Microinjection of small amounts of human full-length DUX4 (DUX4-fl) mRNA into fertilized zebrafish eggs caused asymmetric abnormalities such as less pigmentation of the eyes, altered morphology of ears, developmental abnormality of fin muscle, disorganization of facial musculature and/or degeneration of trunk muscle later in development. Moreover, DUX4-fl expression caused aberrant localization of myogenic cells marked with α-actin promoter-driven enhanced green fluorescent protein outside somite boundary, especially in head region. These abnormalities were rescued by coinjection of the short form of DUX4 (DUX4-s). Our results suggest that the misexpression of DUX4-fl, even at extremely low level, can recapitulate the phenotype observed in FSHD patients in a vertebrate model. These results strongly support the current hypothesis for a role of DUX4 in FSHD pathogenesis. We also propose that DUX4 expression during development is important for the pathogenesis of FSHD.