gebhart/patrepeval huggingface dataset:
Primary Patency of Long-Segment Self-Expanding Nitinol Stents in the Femoropopliteal Arteries (2005)

Midterm restenosis after long-segment femoropopliteal stenting using self-expanding nitinol stents remains a major problem, particularly in patients with diabetes mellitus. The midterm results in nondiabetics are encouraging.
InAsyP1-y Metamorphic Buffer Layers (MBLs) on InP Substrates for Mid-IR Diode Lasers (2009)

InAs QWs grown with InAsyP1-y metamorphic buffer layers on InP substrates demonstrate mid-IR emission. A novel Al-free InAsP/InGaAs SCH design provides improved carrier confinement, allowing InAs QW laser emission near λ~2.5μm @77K.
Low‐Dimensional Nanomaterials Based on Small Organic Molecules: Preparation and Optoelectronic Properties (2008)

Abstract This article presents a comprehensive review of recent progress of research dedicated to low‐dimensional nanomaterials constructed from functional low‐molecular‐weight organic compounds, whose optoelectronic properties are fundamentally different from those of their inorganic counterparts. After introducing the development of inorganic and organic macromolecular nanomaterials, we begin with a general review of the construction strategies for achieving both zero‐dimensional (0D) and one‐dimensional (1D) nanostructures from small organic functional molecules. We then provide an overview of the unique optoelectronic properties induced by molecular aggregation in the nanostructures. Special emphasis is put on the luminescent properties that are different from those of the corresponding bulk materials, such as aggregation‐induced enhanced emission, fluorescence narrowing, multicolor emission, and tunable and switchable emissions from doped nanostructures. We conclude with a summary and our personal view of the direction of future development of organic opto‐functional nanomaterials and devices.
A pragmatic approach to storing and distributing RDF in context using Snippets (2003)

this paper, we&apos;ll present a number of example statements using a syntax of: subject predicate object
On the halt of spontaneous capillary flows in diverging open channels (2017)

Due to their compactness and independence of exterior energy sources, capillary microsystems are increasingly used in many different scientific domains, from biotechnology to medicine and biology, chemistry, energy and space. Obtaining a capillary flow depends on channel geometry and contact angle. A general condition for the establishment of a spontaneous capillary flow in a uniform cross section channel has already been derived from Gibbs free energy. In this work, we consider spontaneous capillary flows (SCF) in diverging open rectangular channels and suspended channels, and we show that they do not flow indefinitely but stop at some location in the channel. In the case of linearly diverging open channels, we derive the expression that determines the location where the flow stops. The theoretical approach is verified by using the Surface Evolver numerical program and is checked by experiments. The approach is extended to sudden enlargements, and it is shown that the enlargements can act as stop and trigger valves.
Archaeology in the Northern Territory (1975)

The various archaeological sites that are being surveyed and examined from the Northern Territory are listed.
Knock-on damage in single wall carbon nanotubes by electron irradiation (1999)

We determine with high resolution transmission electron microscopy the effect of electron irradiation on isolated single wall carbon nanotubes. Observations of in-situ irradiation at electron energies of 80–400 keV suggest that a nanotube is preferentially damaged on surfaces that lie normal to the electron beam, and the threshold energy for knock-on damage is determined to be ∼85 keV. Empirical results are corroborated by calculations based on established anisotropic ejection thresholds.
Removing Camera Shake via Weighted Fourier Burst Accumulation (2015)

Numerous recent approaches attempt to remove image blur due to camera shake, either with one or multiple input images, by explicitly solving an inverse and inherently ill-posed deconvolution problem. If the photographer takes a burst of images, a modality available in virtually all modern digital cameras, we show that it is possible to combine them to get a clean sharp version. This is done without explicitly solving any blur estimation and subsequent inverse problem. The proposed algorithm is strikingly simple: it performs a weighted average in the Fourier domain, with weights depending on the Fourier spectrum magnitude. The method can be seen as a generalization of the align and average procedure, with a weighted average, motivated by hand-shake physiology and theoretically supported, taking place in the Fourier domain. The method's rationale is that camera shake has a random nature, and therefore, each image in the burst is generally blurred differently. Experiments with real camera data, and extensive comparisons, show that the proposed Fourier burst accumulation algorithm achieves state-of-the-art results an order of magnitude faster, with simplicity for on-board implementation on camera phones. Finally, we also present experiments in real high dynamic range (HDR) scenes, showing how the method can be straightforwardly extended to HDR photography.
Educational Uses of the PLATO Computer System (1976)

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Tetrathiafulvalene Porphyrins (2008)

Four tetrathiafulvalene (TTF)-annulated porphyrins 1-4 were synthesized and characterized. All contain a tetraphenylporphyrin (TPP) core onto which four, two, or one TTF subunits were annulated. Absorption and fluorescence spectroscopic studies together with electrochemical investigations reveal that interactions between the porphyrin system and the annulated TTF units take place in solution. The annulation of one or more TTF units to the porphyrin core has a profound effect on the reduction potentials associated with this latter framework, with positive shifts in the range of 0.105 to 0.355 V and 0.200 to 0.370 V for the first and second reduction potential, respectively, compared to the corresponding processes in the model compound TPP, 18. The redox potentials for the first oxidation of the TTF units are considerably shifted in 4 (DeltaE(ox)(1)=+0.285 V) and 2 (DeltaE(ox)(1)=-0.140 V), whereas for 1 and 3 these potentials remain within the region expected for a normal TTF unit. Considerable changes in the second oxidation potential associated with the TTF subunits were seen for 2 (DeltaE(ox)(1)=-0.085) and 3 (DeltaE(ox)(1)=-0.175). The emission spectra of 1-4 revealed that the porphyrin fluorescence is almost quenched in the neutral state of the TTF-annulated porphyrins, a finding that is consistent with substantial electron transfer taking place from the TTF subunits to the porphyrin core. Oxidation of the TTF unit(s) (TTF-->TTF(*+)) present in 1-4 leads to the emission intensity being restored.
[Current applications of high-throughput DNA sequencing technology in antibody drug research]. (2012)

Since the publication of a high-throughput DNA sequencing technology based on PCR reaction was carried out in oil emulsions in 2005, high-throughput DNA sequencing platforms have been evolved to a robust technology in sequencing genomes and diverse DNA libraries. Antibody libraries with vast numbers of members currently serve as a foundation of discovering novel antibody drugs, and high-throughput DNA sequencing technology makes it possible to rapidly identify functional antibody variants with desired properties. Herein we present a review of current applications of high-throughput DNA sequencing technology in the analysis of antibody library diversity, sequencing of CDR3 regions, identification of potent antibodies based on sequence frequency, discovery of functional genes, and combination with various display technologies, so as to provide an alternative approach of discovery and development of antibody drugs.
Association Between Hearing Impairment and Self‐Reported Difficulty in Physical Functioning (2014)

Hearing impairment in older adults is independently associated with greater disability and limitations in multiple self-reported categories of physical functioning.
A Cross- sectional Study on Injuries in Children and Yong Adults in Zhejiang Province (2001)

Objective To study the incidence of injury among children and young adults and the causes of common in juries in urban area of Zhejiang province.Methods 19670 aged 7to 18 years, 19 primary and middle sckools were recruited with stratified cluster sampling during June 2000 to May 2001 .Results 4314 students suffered from varied injuries during the past year.The total incidence was 33.46% (35.54% for boys and 31.41 for girls), with a peak at primary school (aged 10- 12, 41.36%) .The leading causes of injuries were falls (14.25%), collision (4.65%), knife - cutting (4.55%), scalds (1.59%), scalds (1.59%), injury by sharp articles (1.58% ) , which usually occurred due to carelessness in sports, playing, walking and bike - riding. After suffered injuries, 28.96% of total cases were cured in out - clinic and 1.13% in the clinic.78.31 yuan were spent per case.The occupations and education degerees of their parents strongly affected the incidence of injuries of their kids. Conclusions Injury was a common and frequently incident among children and young adults and could seriously affect their health and family. Health education and health promotion are the important measures to prevent from in juries.
Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance (2000)

The partial allosteric modulators (PAMs) of gamma-aminobutyric acid-gated Cl(-) current intensities at gamma-aminobutyric acid type A receptors have high affinity but low intrinsic efficacy on benzodiazepine recognition sites. Unlike the full allosteric modulators (FAM), like alprazolam, triazolam, and diazepam, PAMs are virtually devoid of unwanted side effects, including tolerance. Imidazenil (IMD) is a PAM that elicits potent anxiolytic and anticonvulsant actions in rodents and nonhuman primates and retains its anticonvulsant and anxiolytic effects, even in rodents that are tolerant to FAMs. IMD antagonizes the side effects of FAMs in rodents and nonhuman primates. Using patas monkeys and a multiple schedule with repeated acquisition and performance of chain responses, we report that IMD administration for 17 days antagonized without showing tolerance ALP-induced disruption of acquisition.
Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703 (2015)

Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine-guanine motifs (CpG ODN), are recognized by the innate immune system as "danger signals." CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability, which cause toxicities in mice and primates. We therefore designed a covalently closed DNA molecule (dSLIM(®)) where two single-stranded loops containing CG motifs are connected through a double-stranded stem in the absence of any nonnatural DNA component. The most promising immunomodulator, MGN1703, comprises two loops of 30 nucleotides containing three CG motifs each, and a connecting stem stem of 28 base pairs. MGN1703 stimulates cytokine secretion [interferon (IFN)-α, IFN-γ, interleukin (IL)-12, IL-6, and IL-2] and activates immune cells by increased expression of CD80, CD40, human leukocyte antigen (HLA)-DR and ICAM-1. Efficacy of immunomodulation strictly depends on the descriptive dumbbell shape and size of the molecule. Variations in stem length and loop size lead to reduced potency of the respective members of the dSLIM(®) class. In a representative mouse model, toxicities from injections of high amounts of a CpG ODN-PT and of MGN1703 were evaluated. The CpG ODN-PT group showed severe organ damage, whereas no such or other pathologies were found in the MGN1703 group. Oncological clinical trials of MGN1703 already confirmed our design.
An inverse scattering internal multiple elimination method: beyond attenuation, a new algorithm and initial tests (2005)

We present our initial research efforts to address the complete removal of internal multiples from seismic data, without destroying primary reflections and with absolutely no knowledge of the subsurface. The current procedure with these characteristics is an attenuator based on inverse scattering series. In order to move towards elimination we can either: introduce a variable background, or study higher order terms in the inverse scattering series with a constant background and find the subseries that is going to remove internal multiples. Although both approaches are worth pursuing, the concepts and methods of this paper belong to the second category. Avoiding the need for a velocity model can have a significant practical advantage, especially in the cases when the adequate velocity is unobtainable. We provide an improved amplitude prediction by identifying and selecting higher order terms for the inverse scattering internal multiple elimination series. We obtain a leading order subseries for elimination of internal multiples and its closed form. Analytical and numerical examples will be used to exemplify the concept of elimination of internal multiples based on inverse scattering series and to define the current state of understanding of this approach.
Transplantation of Mesenchymal Stem Cells within a Poly(lactide- <i>Co</i> -ɛ-caprolactone) Scaffold Improves Cardiac Function in a Rat Myocardial Infarction Model (2009)

Mesenchymal stem cells plus PLCL should be an excellent combination for cardiac tissue engineering.
Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene (1998)

In this work, we explored the existence of genetic variants within the apolipoprotein E gene transcriptional regulatory region, using a denaturing gradient gel electrophoresis screening of a region comprising nucleotides -1017 to +406. Upon a population study, three new polymorphic sites (-491, -427 and -219) and two mutations were found. Functional effects of the polymorphisms, assayed by transient transfection and electrophoretic mobility shift assays in a human hepatoma cell line, showed that polymorphisms at sites -491 and -219 of the APOE promoter produce variations in the transcriptional activity of the gene, most probably through differential binding of nuclear proteins.
DEVELOPMENT AND SIGNIFICANCE OF ZIDOVUDINE RESISTANCE IN CHILDREN INFECTED WITH HUMAN IMMUNODEFICIENCY VIRUS (1994)

In HIV-infected children ZDV-resistant HIV strains are associated with diminished drug efficacy and more rapid disease progression.
HTS by NMR for the Identification of Potent and Selective Inhibitors of Metalloenzymes (2018)

We have recently proposed a novel drug discovery approach based on biophysical screening of focused positional scanning libraries in which each element of the library contained a common binding moiety for the given target or class of targets. In this Letter, we report on the implementation of this approach to target metal containing proteins. In our implementation, we first derived a focused positional scanning combinatorial library of peptide mimetics (of approximately 100,000 compounds) in which each element of the library contained the metal-chelating moiety hydroxamic acid at the C-terminal. Screening of this library by nuclear magnetic resonance spectroscopy in solution allowed the identification of a novel and selective compound series targeting MMP-12. The data supported that our general approach, perhaps applied using other metal chelating agents or other initial binding fragments, may result very effective in deriving novel and selective agents against metalloenzyme.
Lack of inducible nitric oxide synthase activity in T cell clones and T lymphocytes from naive and <i>Leishmania major</i>‐infected mice (1995)

Nitric oxide (NO) generated by the inducible isoform of nitric oxide synthase (iNOS) is implicated in a number of immunological processes including killing of intracellular parasites, suppression of T cell proliferation, production of cytokines and destruction of tissue in autoimmune diseases. Considering that cytokine-activated mouse macrophages, fibroblasts and endothelial cells are potent producers of NO, we investigated whether T cells, as central participants in immune responses, can also be activated for the release of NO. Neither thymocytes nor type 1 or type 2 T helper cell clones generated significant amounts of nitrite (the stable end product of NO in culture supernatants) when stimulated by T cell mitogens, cytokines or antigen in the presence of irradiated antigen-presenting cells. Similarly, T cells freshly isolated from mice acutely infected with the intracellular pathogen Leishmania major did not produce NO upon restimulation in vitro. The lack of NO production was not due to the expression of enzymatically inactive iNOS, as we were unable to detect any iNOS protein in activated T helper clones or in freshly isolated T cells from infected mice by Western (protein) blot analysis. Finally, we tested whether iNOS expression in T cells might be restricted to a minor subpopulation and therefore only detectable on a single cell level. After immunofluorescence staining of lymph node or spleen cells from infected mice with antibodies against iNOS, F4/80- or Thy-1-antigen, macrophages, but no T cells, were found to express iNOS. Thus, we have no evidence that activated T helper cell clones or T cells from L. major-infected mice are high producers of NO.
Spectral Data Analysis by Two-Dimensional Representation of Derivatives (1999)

In this paper I propose a Di-Dj plot method that expresses pairs of ith and jth derivatives in a two-dimensional representation as a rational method to describe spectral waveforms. The basic concepts of the method are explained, and some examples of its applications are given to demonstrate the usefulness of the method in spectral analysis. First, I discuss the effects of plotting the correlations of derivatives of different powers—second vs. first and third vs. fourth—to separate adjacent bands, as well as the effect of adding a nonflat background to the spectrum. Next, a number of derivative correlation plots for Gaussian and Lorentzian shaped bands are described. Third, I show how the method can be used to determine the presence of an underlying band and how to extract the two bands from the original band. As examples of its applications, a waveform analysis of infrared spectra, the determination of the optimum cell pathlength for a water sample, and an analysis of temperature-dependent changes in a near-infrared (NIR) spectrum for water are discussed.
Preparation of liposome encapsulating angiotensin-I-converting enzyme inhibitory peptides from sunflower protein hydrolysates (2018)

Liposomal angiotensin-I-converting enzyme inhibitory (ACEI) peptides were prepared from sunflower protein hydrolysates by the thin‑film ultrasonic method. Response surface methodology (RSM), in combination with fractional factorial designs and central composite design methods were utilized to optimize entrapment efficiency and balance the drug release. We found that the ratio of phospholipids to cholesterol, ultrasound time and the ratio of phospholipids to ACEI peptides were significant factors affecting entrapment efficiency (P<0.001). Optimal preparation conditions of liposomal‑ACEI peptides were the ratio of soybean phospholipids to cholesterol (w/w) of 4.1:1, PEG‑2000 dosage (%) of 4, NaCl concentration in PBS (mM) of 50, hydration temperature of 45˚C, ultrasound time of 8.05 min and the ratio of soybean phospholipids to ACEI peptides of 15:1 (w/w). The experimental entrapment efficiency of liposomal‑ACEI peptides was (91.25±0.182%). Moreover, the balanced release rate of liposome encapsulated ACEI in phosphate buffer was 77.83% after 12 h.
The Acetylation of Lactic Esters by Ketene (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Acetylation of Lactic Esters by KeteneH. V. Claborn and Lee T. SmithCite this: J. Am. Chem. Soc. 1939, 61, 10, 2727–2728Publication Date (Print):October 1, 1939Publication History Published online1 May 2002Published inissue 1 October 1939https://pubs.acs.org/doi/10.1021/ja01265a048https://doi.org/10.1021/ja01265a048research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Characterization of Flexible Hydrogel Electrodes for Electrochemical Impedance Measurements of Protective Coatings on Metal Sculptures (2014)

Abstract A novel conductive anionic hydrogel was synthesized for use as a solid electrolyte for electrochemical impedance spectroscopy (EIS) characterization of the barrier properties of protective coatings on outdoor metalworks, such as bronze sculptures. The AMPS‐co‐PAA hydrogel was soaked in a variety of aqueous salt solutions and characterized by swelling capacity and conductivity in order to determine the most appropriate gel/liquid electrolyte combination for use on culturally significant objects. K 2 PIPES‐equilibrated hydrogels were selected as the preferred electrodes for this particular application and were used to measure the impedance of a coated substrate, yielding spectra similar to those from standard liquid cells.
Formar en recreación, un sueño o una realidad (2010)

La formación en recreación para algunos resulta una utopía, compleja, difícil y de poca sustentación, sin embargo, desde hace ya muchos años, con los Planes Nacionales de Recreación se había venido sosteniendo que era necesario cualificar y formar al talento humano que comprendiera que la intervención en recreación necesita una mirada holística e integral que propenda por el desarrollo humano (Pineda y Osorio, 2000).
Naturally Occurring Toxic Alkaloids in Foods (1981)

(1981). Naturally Occurring Toxic Alkaloids in Foods. CRC Critical Reviews in Toxicology: Vol. 9, No. 1, pp. 21-104.