gebhart/patrepeval huggingface dataset:
Spectroscopic Capture and Reactivity of a Low‐Spin Cobalt(IV)‐Oxo Complex Stabilized by Binding Redox‐Inactive Metal Ions (2014)

High-valent cobalt-oxo intermediates are proposed as reactive intermediates in a number of cobalt-complex-mediated oxidation reactions. Herein we report the spectroscopic capture of low-spin (S=1/2) Co(IV)-oxo species in the presence of redox-inactive metal ions, such as Sc(3+), Ce(3+), Y(3+), and Zn(2+), and the investigation of their reactivity in C-H bond activation and sulfoxidation reactions. Theoretical calculations predict that the binding of Lewis acidic metal ions to the cobalt-oxo core increases the electrophilicity of the oxygen atom, resulting in the redox tautomerism of a highly unstable [(TAML)Co(III)(O˙)](2-) species to a more stable [(TAML)Co(IV)(O)(M(n+))] core. The present report supports the proposed role of the redox-inactive metal ions in facilitating the formation of high-valent metal-oxo cores as a necessary step for oxygen evolution in chemistry and biology.
Identification and functional characterization of the nascent RNA contacting residues of the hepatitis C virus RNA-dependent RNA polymerase (2012)

Understanding how the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) interacts with nascent RNA would provide valuable insight into the virus's mechanism for RNA synthesis. Using a peptide mass fingerprinting method and affinity capture of peptides reversibly cross-linked to an alkyn-labeled nascent RNA, we identified a region below the Δ1 loop in the fingers domain of the HCV RdRp that contacts the nascent RNA. A modification protection assay was used to confirm the assignment. Several mutations within the putative nascent RNA binding region were generated and analyzed for RNA synthesis in vitro and in the HCV subgenomic replicon. All mutations tested within this region showed a decrease in primer-dependent RNA synthesis and decreased stabilization of the ternary complex. The results from this study advance our understanding of the structure and function of the HCV RdRp and the requirements for HCV RNA synthesis. In addition, a model of nascent RNA interaction is compared with results from structural studies.
Enhancing mobile data offloading with mobility prediction and prefetching (2012)

We present procedures that exploit mobility prediction and prefetching to enhance offloading of traffic from mobile networks to WiFi hotspots, for both delay tolerant and delay sensitive traffic. We evaluate the procedures in terms of the percentage of offloaded traffic, the data transfer delay, and the cache size used for prefetching. The evaluation considers empirical measurements and shows how various parameters influence the performance of the procedures, and their robustness to time and throughput estimation errors.
The Pratylenchus penetrans Transcriptome as a Source for the Development of Alternative Control Strategies: Mining for Putative Genes Involved in Parasitism and Evaluation of in planta RNAi (2015)

The root lesion nematode Pratylenchus penetrans is considered one of the most economically important species within the genus. Host range studies have shown that nearly 400 plant species can be parasitized by this species. To obtain insight into the transcriptome of this migratory plant-parasitic nematode, we used Illumina mRNA sequencing analysis of a mixed population, as well as nematode reads detected in infected soybean roots 3 and 7 days after nematode infection. Over 140 million paired end reads were obtained for this species, and de novo assembly resulted in a total of 23,715 transcripts. Homology searches showed significant hit matches to 58% of the total number of transcripts using different protein and EST databases. In general, the transcriptome of P. penetrans follows common features reported for other root lesion nematode species. We also explored the efficacy of RNAi, delivered from the host, as a strategy to control P. penetrans, by targeted knock-down of selected nematode genes. Different comparisons were performed to identify putative nematode genes with a role in parasitism, resulting in the identification of transcripts with similarities to other nematode parasitism genes. Focusing on the predicted nematode secreted proteins found in this transcriptome, we observed specific members to be up-regulated at the early time points of infection. In the present study, we observed an enrichment of predicted secreted proteins along the early time points of parasitism by this species, with a significant number being pioneer candidate genes. A representative set of genes examined using RT-PCR confirms their expression during the host infection. The expression patterns of the different candidate genes raise the possibility that they might be involved in critical steps of P. penetrans parasitism. This analysis sheds light on the transcriptional changes that accompany plant infection by P. penetrans, and will aid in identifying potential gene targets for selection and use to design effective control strategies against root lesion nematodes.
Mesoporous M41S materials in capillary gas chromatography (1997)

M. Raimondo, G. Perez, M. Sinibaldi, A. De Stefanis and A. A. G. Tomlinson, Chem. Commun., 1997, 1343 DOI: 10.1039/A702849K
Transfer of the Metallothionein-Human Growth Hormone Fusion Gene into Channel Catfish (1987)

The metallothionein-human growth hormone fusion gene (MThGH), constructed by fusing the mouse metallothionein promoter with the human growth hormone gene, was microinjected into the cytoplasm of one-cell embryos of channel catfish Ictalurus punctatus. The 3-week-old fish that developed were analyzed for integrated copies of the MThGH gene. Two of 10 animals contained MThGH sequences that comigrated with genomic DNA of high molecular weight in southern blots. The MThGH sequences were organized in head-to-tail tandem arrays that are characteristic of foreign genes integrated into recipient cell genomes. These data strongly suggest that the MThGH genes are stably integrated into chromosomal DNA, and that transgenic channel catfish can be generated by cytoplasmic injection of early embryos.
Database Operations Using Asynchronous Remote Method Invocation (2012)

Today?s highly scalable Internet applications are largely bound by speed-of-light communication delays between geographically disparate data centers. This latency is particularly problematic when writing to distributed database systems because waiting for messages to travel halfway around the world is often unacceptable, and maintaining any notion of consistency is exceedingly difficult when using modern asynchronous architectures. We present a novel architecture, based on asynchronous remote method invocation, that achieves interesting consistency guarantees, even when performing write operations asynchronously. An analysis of our implementation demonstrates that this solution can provide an intuitive interface to developers, and doesn?t require any specialized knowledge of databases, SQL (Standard Query Language), or transactions.
Automatic seed set expansion for trust propagation based anti-spamming algorithms (2009)

Seed sets are of significant importance for trust propagation based anti-spamming algorithms, e.g., TrustRank. Conventional approaches require manual evaluation to construct a seed set, which restricts the seed set to be small in size, since it would cost too much and may even be impossible to construct a very large seed set manually. The small-sized seed set can cause detrimental effect on the final ranking results. Thus, it is desirable to automatically expand an initial seed set to a much larger one. In this paper, we propose the first automatic seed set expansion algorithm (ASE), which expands a small seed set by selecting reputable seeds that are found and guaranteed to be reputable through a joint recommendation link structure. Experimental results on the WEBSPAM-2007 dataset show that with the same manual evaluation efforts, ASE can automatically obtain a large number of reputable seeds with high precision, thus significantly improving the performance of the baseline algorithm in terms of both reputable site promotion and spam site demotion.
The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N (2001)

AQ4N is a bioreductive drug that can significantly enhance the anti-tumour effect of radiation and cyclophosphamide. The aim of this study was to examine the ability of AQ4N to potentiate the anti-tumour effect of cisplatin and to compare it to the chemopotentiation effect of tirapazamine. In the T50/80 murine tumour model, AQ4N (50-100 mg/kg) was administered 30 min, 2.5 or 6 h prior to cisplatin (4 mg/kg or 8 mg/kg); this produced an anti-tumour effect that was approximately 1.5 to 2 times greater than that achieved by a single 4 or 8 mg/kg dose of cisplatin. Tirapazamine (25 mg/kg) administered 2.5 h prior to cisplatin (4 mg/kg) resulted in a small increase in anti-tumour efficacy. AQ4N was also successful in enhancing the anti-tumour effect of cisplatin in the SCCVII and RIF-1 murine tumour models. This resulted in an increased cell kill of greater than 3 logs in both models; this was a greater cell kill than that observed for tirapazamine with cisplatin. Combination of cisplatin with AQ4N or tirapazamine resulted in no additional bone marrow toxicity compared to cisplatin administered alone. In conclusion, AQ4N has the potential to improve the clinical efficacy of cisplatin.
Cache management algorithms for flexible filesystems (1993)

Cache management in flexible filesystems deals with the problem of determining a cached file to be replaced when the local cachespace is exhausted. In analogy to virtual memory management, several different algorithms exist for managing cached files. In this paper we simulate the behavior of First-In-First-Out (FIFO), Least Recently Used (LRU), Least Frequently Used (LFU) and a variation of LFU we call the File Length Algorithm (LEN) from the viewpoint of file access times, cache hit ratios and availability. The results of several simulation runs are presented and interpreted.
Dose-Finding Study of the Novel Tuberculosis Vaccine, MVA85A, in Healthy BCG-Vaccinated Infants (2011)

MVA85A was safe and induced robust, polyfunctional, durable CD4 and CD8 T-cell responses in infants. These data support efficacy evaluation of MVA85A to prevent tuberculosis in infancy. Clinical Trials Registration. NCT00679159.
A wide range high sensitivity film balance (1980)

A film balance has been constructed that features a wide range (∼80 dynes/cm) and high sensitivity (∼10−3 dyne/cm). The device is rugged, simple to operate and can be repeatedly assembled/disassembled in cycles (for cleanings) without affecting its mechanical parameters (nullpoint and sensitivity).
Anomalous Diffraction Gratings (1935)

Gratings similar to those described and studied by the author in 1907 and 1912 have been more fully investigated. They show narrow bright and dark bands in the continuous spectrum of a white source. Classical theory has never accounted for these anomalies, though tentative efforts were made at the time by Lord Rayleigh. The present work was done with a chromium plated echelette grating of 7200 lines to the inch ruled on copper, and one of 15,000 lines ruled by Dr. Babcock on an aluminum film on glass. The behavior of the bands as the incidence angle is altered has been very completely recorded by photography and the energy missing in the grating spectra has been found in excess in the spectrum of the central image. The dark bands appear to be due to the circumstance that diffracted wavelets from the lines are inhibited by the collective effects from neighboring lines, i.e., there is a sort of destructive interference along the plane of the grating. This obtains, however, only when the grating space is equal to an integral multiple of $\ensuremath{\lambda}$ (for normal incidence) which means that the dark bands correspond to $\ensuremath{\lambda}$ values which are passing off the grating on both sides at grazing emergence. The spectra formed by the Al grating are completely plane polarized, because of the circumstance that the width of the scratches is considerably less than the wave-length of the light. The dynamical action of the gratings is discussed, and the anomalous behavior is shown to be due to the presence of exceedingly narrow diffracting elements, which may be present even in the case of rather coarse rulings.
Soyasapogenol A and B Distribution in Soybean (<i>Glycine max </i>L. Merr.) in Relation to Seed Physiology, Genetic Variability, and Growing Location (2003)

An efficient analytical method utilizing high-performance liquid chromatography (HPLC)/evaporative light scattering detector (ELSD) was developed to isolate and quantify the two major soyasaponin aglycones or precursors in soybeans, triterpene soyasapogenol A and B. Soaking of seeds in water up to 15 h did not change the content of soyasapogenols. Seed germination had no influence on soyasapogenol A content but increased the accumulation of soyasapogenol B. Soyasapogenols were mainly concentrated in the axis of the seeds as compared with the cotyledons and seed coat. In the seedling, the root (radicle) contained the highest concentration of soyasapogenol A, while the plumule had the greatest amounts of soyasapogenol B. In 10 advanced food-grade soybean cultivars grown in four locations in Ontario, total soyasapogenol content in soybeans was 2 +/- 0.3 mg/g. Soyasapogenol B content (1.5 +/- 0.27 mg/g) was 2.5-4.5-fold higher than soyasapogenol A content (0.49 +/- 0.1 mg/g). A significant variation in soyasapogenol content was observed among cultivars and growing locations. There was no significant correlation between the content of soyasapogenols and the total isoflavone aglycones.
An Efficient FTL Design for Multi-chipped Solid-State Drives (2010)

Although solid-state drives seem being excellent alternatives to replace hard disks in mobile devices, serious challenges arise due to performance and reliability concerns. This work targets performance enhancement designs with the considerations of low-cost MLC flash memory. In particular, an efficient flash management design is proposed to manage multi-chipped flash memory with cache support, where a two-level address translation mechanism is presented with an adaptive caching policy. The capability of the proposed approach is evaluated with a SystemC-based solid-state-drive simulator based on realistic workloads and benchmarks. It was shown that the proposed approach could significantly improve the performance of multi-chipped solid-state drives over various hardware configurations.
Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel (2011)

Background. The aim of this paper was to evaluate the activity and tolerability of docetaxel (D) and bevacizumab (Bev) in patients with metastatic castrate-resistant prostate cancer (CRPC) previously exposed to D. Methods. Treatment consisted of D 30 mg/m(2) i.v. for four consecutive weekly administrations followed by a 2-week rest interval, in addition to Bev 5 mg/kg i.v. every 2 weeks. Results. Forty-three patients were enrolled: a PSA response was observed in 27 patients (62.7%, 95% CI: 0.41 to 0.91), and a palliative response was achieved in 31 patients (72.1%, 95%CI: 0.48 to 1.02). After a median followup of 11.3 months, only five patients had died. The regimen was generally well tolerated. Conclusion. Weekly D + biweekly Bev seems to be an effective and well-tolerated treatment option for patients with metastatic CRPC previously exposed to D-based chemotherapy.
Effects of Strip Intercropping and No-Tillage on Some Pests and Beneficial Invertebrates of Corn in Ohio (1991)

We tested two agronomic practices that are likely to increase plant and structural diversity, no-tillage and strip intercropping, for effects on corn invertebrate fauna. Some of the most common herbivores and natural enemies were sampled by direct counts and damage estimation from 1988 through 1990 on monoculture corn and strips of corn alternated with soybean, under no-tillage and conventional tillage. Among soil pests, cutworms (mostly the black cutworm, Agrotis ipsilon (Hufnagel)); armyworm, Pseudaletia unipuncta (Haworth); and slugs (Gastropoda) were more abundant in no-tillage plots, although only slugs caused severe damage. The western corn rootworm, Diabrotica virgifera virgifera LeConte, and the European corn borer, Ostrinia nubilalis (Hübner), were generally more abundant in conventional tillage plots. Despite crop rotation, the strip-intercropping system (four rows of each crop) was less effective in reducing western corn rootworm infestation, especially in conventional tillage plots. In 1990 only, ladybugs (mostly Coleomegilla maculata (DeGeer)) were more abundant in conventional tillage plots, whereas tarnished plant bugs, Lygus lineolaris (Palisot de Beauvois), were more abundant in notillage plots. Japanese beetle, Popillia japonica Newman; stink bugs, Acrosternum hilare (Say) and Euschistus servus (Say); and spiders (Aranea) were not significantly affected by treatments.
Quality Assurance in Environmental Monitoring (1995)

Quality assurance in environmental monitoring , Quality assurance in environmental monitoring , کتابخانه دیجیتال جندی شاپور اهواز
Use of rotation thromboelastometry (ROTEM <sup>®</sup> ) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate (2009)

Goal-directed coagulation therapy is essential in the management of trauma patients with severe bleeding. Due to the complex nature of coagulation disorders in trauma, a quick and reliable diagnostic tool is essential. We report a severely injured multiple trauma patient who received haemostatic therapy with coagulation factor concentrates, guided by rotational thromboelastometry (ROTEM). Initial therapy consisted of fibrinogen concentrate (Haemocomplettan P), as maximum clot firmness in the ROTEM analyses was low, whereas clotting time was normal. Later on, prothrombin complex concentrate was given to optimise thrombin generation. This approach enabled extended emergency hemihepatectomy to be performed without using fresh frozen plasma. As the EXTEM maximum clot firmness showed good clot quality, no platelets were transfused despite low platelet counts. This case shows the potential success of treatment using both fibrinogen concentrate and prothrombin complex concentrate, not only in restoring haemostasis but also in minimising requirement for transfusion of allogeneic blood products.
Using Intrusive Microservices to Enable Deep Customization of Multi-tenant SaaS (2018)

Enterprise software applications need to be customized in order to meet special requirements from customers. When the customization requirements are beyond the prediction of vendors, deep customization is needed, and traditionally customers do deep customizations by directly modifying the application source code. When the applications are moving from on-premises to multi-tenant Software as a Service, directly changing code is not feasible because many customers are sharing one instance of the application code. In this paper, we present a new approach to enable deep customization on multi-tenant SaaS, using intrusive microservices. The custom code is implemented as an isolated and self-contained microservice running beside the main service, and it uses callback code to intrusively execute queries or commands inside the main service. We present the key techniques behind intrusive microservices and illustrate how turned an open source online shopping application into a deeply customizable multi-tenant service.
Structure of 5-methoxy-2-{[4-methoxy-3,5-dimethyl-2-pyridinylmethyl]sulfinyl}-1H-benzimidazole (omeprazole) (1989)

C17H19N3O3S, Mr = 345.42, triclinic, P1, a = 10.686 (5), b = 10.608 (7), c = 9.666 (6) A, alpha = 119.75 (5), beta = 112.02 (5), gamma = 68.33 (4) degrees, V = 859 (1) A3, Z = 2, Dm = 1.332 (2), Dx = 1.335 g cm-3, Cu K alpha, lambda = 1.5418 A, mu = 18.04 cm-1, F(000) = 364, T = 293 K, R = 0.057 for 1962 observed reflections. The methylsulfinyl group, which adopts a trans conformation, links the pyridine and benzimidazole rings in an almost coplanar orientation. Thus the molecule, as a whole, adopts a nearly extended form. Two centrosymmetrically related molecules form a cyclic dimer by intermolecular N-H...O hydrogen bonding, and the dimers are held together by van der Waals contacts between the neighboring aromatic rings in the crystal structure.
Programming amazon web services (2008)

Building on the success of its storefront and fulfillment services, Amazon now allows businesses to rent computing power, data storage and bandwidth on its vast network platform. This book demonstrates how developers working with small- to mid-sized companies can take advantage of Amazon Web Services (AWS) such as the Simple Storage Service (S3), Elastic Compute Cloud (EC2), Simple Queue Service (SQS), Flexible Payments Service (FPS), and SimpleDB to build web-scale business applications. With AWS, Amazon offers a new paradigm for IT infrastructure: use what you need, as you need it, and pay as you go. Programming Web Services explains how you can access Amazon's open APIs to store and run applications, rather than spend precious time and resources building your own. With this book, you'll learn all the technical details you need to: Store and retrieve any amount of data using application servers, unlimited data storage, and bandwidth with the Amazon S3 serviceBuy computing time using Amazon EC2's interface to requisition machines, load them with an application environment, manage access permissions, and run your image using as many or few systems as neededUse Amazon's web-scale messaging infrastructure to store messages as they travel between computers with Amazon SQSLeverage the Amazon FPS service to structure payment instructions and allow the movement of money between any two entities, humans or computersCreate and store multiple data sets, query your data easily, and return the results using Amazon SimpleDB.Scale up or down at a moment's notice, using these services to employ as much time and space as you need Whether you're starting a new online business, need to ramp up existing services, or require an offsite backup for your home, Programming Web Services gives you the background and the practical knowledge you need to start using AWS. Other books explain how to build web services. This book teaches businesses how to take make use of existing services from an established technology leader.
Data-aggregation techniques in sensor networks: A survey (2006)

Wireless sensor networks consist of sensor nodes with sensing and com- munication capabilities. We focus on data-aggregation problems in energy- constrained sensor networks. The main goal of data-aggregation algorithms is to gather and aggregate data in an energy efficient manner so that net- work lifetime is enhanced. In this article we present a survey of data-aggre- gation algorithms in wireless sensor networks. We compare and contrast different algorithms on the basis of performance measures such as lifetime, latency, and data accuracy. We conclude with possible future research directions.
Extreme Hyperphosphatemia and Acute Renal Failure after a Phosphorus-Containing Bowel Regimen (1999)

Phosphate intoxication, manifested by hypocalcemic tetany and acute renal failure, may complicate bowel-cleansing preparations which contain phosphate. These preparations are commonly used to prepare patients for various gastrointestinal procedures. Often, patients who receive these regimens are at increased risk of phosphate intoxication from diseases which slow gastrointestinal transit or decrease renal excretion (renal insufficiency). We present a patient who developed oliguric acute renal failure from severe phosphate intoxication associated with a phosphate-containing bowel-cleansing regimen.