gebhart/patrepeval huggingface dataset:
Scheduling Flexible Servers with Convex Delay Costs in Many-Server Service Systems (2008)

In a recent paper we introduced the queue-and-idleness ratio (QIR) family of routing rules for many-server service systems with multiple customer classes and server pools. A newly available server serves the customer from the head of the queue of the class (from among those the server is eligible to serve) whose queue length most exceeds a specified proportion of the total queue length. Under fairly general conditions, QIR produces an important state-space collapse as the total arrival rate and the numbers of servers increase in a coordinated way. That state-space collapse was previously used to delicately balance service levels for the different customer classes. In this sequel, we show that a special version of QIR stochastically minimizes convex holding costs in a finite-horizon setting when the service rates are restricted to be pool dependent. Under additional regularity conditions, the special version of QIR reduces to a simple policy: linear costs produce a priority-type rule, in which the least-cost customers are given low priority. Strictly convex costs (plus other regularity conditions) produce a many-server analogue of the generalized-cμ (Gcμ) rule, under which a newly available server selects a customer from the class experiencing the greatest marginal cost at that time.
A Retrace Driven Television Horizontal Deflection Circuit (1966)

A general trend for the use of silicon controlled rectifiers (SCR) in television line-scanning generators leads, in principle, to new circuit configurations /1/, in which the deflection coils are driven during the retrace via a switching element. Instead of the SCR, transistors may be used as well, In the present paper, optimum working conditions of this circuit diagram are determined and equations derived enabling a simple engineering design of this generator. The wiring diagram mentioned in the paper has a high-voltage circuit part designed in an unique way.
Monocular Outlier Detection for Visual Odometry (2017)

In this paper, we propose an optimization scheme to detect outliers in a visual odometry pipeline that is purely based on the optical flow of one monocular camera without requiring information about depth. First, we review different optical flow error measures and uncover the different sensitivity changes of the endpoint error for optical flow to the directional and the absolute error components. Then, we analyse the dependency of the direction of the flow induced by the translational components of the camera motion assuming the flow induced by the rotational camera motion components to be known. Based on a reliable estimate of the focus of expansion, we solve for a normalized directional flow error that takes the influence of the discretization error induced by the pixel size into account. Here, a circular and a squared error bound on the discretization error is investigated. Finally, we present a monocular outlier detection pipeline including the normalized directional flow error as a suitable constant threshold criterion almost invariant to the camera motion and the scene geometry. Further on, evaluations of the overall monocular outlier detection method called FERO included in a stereo visual odometry pipeline are given to compare the performance of monocular against stereoscopic outlier detection based on Kitti benchmark.
Algorithm 748: enclosing zeros of continuous functions (1995)

Two efficient algorithms for enclosing a zero of a continuous function are presented. They are similar to the recent methods, but together with quadratic interpolation they make essential use of inverse cubic interpolation as well. Since asymptotically the inverse cubic interpolation is always chosen by the algorithms, they achieve higher-efficiency indices: 1.6529… for the first algorithm, and 1.6686… for the second one. It is proved that the second algorithm is optimal in a certain family. Numerical experiments show that the two new methods compare well with recent methods, as well as with the efficient solvers of Dekker, Brent, Bus and Dekker, and Le. The second method from the present article has the best behavior of all 12 methods especially when the termination tolerance is small.
Effects of Cycling Ranges on Stress and Capacity Fade in Lithium-Ion Pouch Cells (2016)

The coupling between mechanics and electrochemistry can be a useful tool in identifying battery aging. Here we investigate the relationship between stress and capacity fade in different types of commercial batteries under various cycling ranges. We identify individual contributions from stress-increasing mechanisms, such as film growth, and non-linear stress relaxation mechanisms. Different cycling ranges affect the average stress level inside the batteries, leading to varying levels of stress relaxation, which dominates the overall stress behavior initially, but gradually is overtaken by linear stress-increasing mechanisms at higher cycle number. The slopes of the linear film growth vary with cycling range and battery type, and we correlate these effects with both mechanical and electrochemical phenomena. Commercial batteries with different compositions exhibit qualitatively similar results on stress vs. state of health (SOH), but vary quantitatively due to differences in their mechanical properties, which can be identified through mechanical tests.
THE HOST CELL RESPONSE IN THE LOCAL GRAFT-<i>VERSUS</i>-HOST REACTION INDUCED IN THE KIDNEYS OF F1 RATS BY PARENTAL THORACIC DUCT LYMPHOCYTES (1972)

Radioautographs of infiltrative cells in the kidneys of (Lewis x BN)F(1) rats labeled with tritiated thymidine (TdR(3)H) before the subcapsular injection of parental (Lewis) thoracic duct lymphocytes (TDL) showed a predominantly host-proliferative response by 4 days after grafting. The immediate renal incorporation of TdR(3)H was used to measure the local graft-vs.-host (GVH) reactions. Substantial reactions could still be induced in the face of the considerable degree of leukopenia after 400 R whole body gamma-irradiation. These results suggest that radioresistant cells are capable of carrying on the appropriate host activities and that the weakness of GVH reactions induced after higher doses of irradiation may be due to impairment of the mitotic mechanism of host cells. The importance of circulating leukocytes as a source of immunogenic stimulation was nevertheless substantiated by inducing local GVH reactions with Lew TDL in chimeric parental-type rats that had been repopulated with F(1) bone marrow. This result also emphasizes the nonspecific nature of tissue destruction in the renal GVH reaction in confirmation of Elkins. In this and other situations in which B cells were the predominant F(1) type elements available for interaction with parental-type TDL the reactions were nearly equivalent or equivalent to those in the appropriate controls. Typical local GVH reactions could be induced in heavily irradiated hosts by an inoculum of combined parental and F(1)-type TDL in the apparent absence of mononuclear phagocytes. The possible relationship between the activation of host lymphocytes, the involvement of B cells, and the nonspecific nature of tissue damage in the renal GVH is discussed.
Theoretical Analysis of Power Flow and Stored Energy in the Capacitor of Neutral-Point-Clamped Modular Multilevel Converter (2019)

This paper describes theoretical analysis of a power flow and a total stored energy in the capacitor of a neutral-point-clamped modular multilevel converter (NPC-MMC). The NPC-MMC consists of both a three-level structure with common DC capacitors and chopper cells. It requires only half of chopper cells compared to the conventional MMC. In this paper, at first, theoretical analysis reveals the NPC-MMC can supply the AC power from not only the cells but also common DC capacitors. The direct power flow between the DC capacitors and the AC side brings 48% reduction of the total stored energy in the cell capacitors and the DC capacitors to the conventional MMC. Secondary, the 10-kVA experimental circuit using low-voltage MOSFETs validates the capacitor energy analysis. Measured efficiency reaches extremely high value of 99.3%. Therefore, it requires neither heat sink nor cooling fans. These experimental results show that the NPC-MMC can realize both downsizing and very high efficiency conversion.
RESISTANCE OF THE BUFFALO FLY, <i>HAEMATOBIA IRRITANS EXIGUA</i> (DE MEIJERE), TO TWO SYNTHETIC PYRETHROIDS AND DDT (1982)

Abstract After 2 years of use, the synthetic pyrethroid fenvalerate failed to control a population of Haematobia irritans exigua from the Mackay district in central coastal Queensland. Dosage mortality tests on the flies indicated a moiety that was 45 x, 29 x and > 1000 x more resistant respectively to fenvalerate, cypermethrin and DDT than a moiety in a reference population of flies which had not been subjected to control by fenvalerate.
CaMoO4 ELECTRONICALLY TUNABLE OPTICAL FILTER (1970)

The paper describes a CaMoO4 transmission-type acousto-optic filter. Tuning from about 6700 to 5100 Å is obtained by changing an acoustic frequency from 40 to 68 MHz. The filter bandwidth is 8 Å at an f/6 aperture. 95% transmission is obtained at an acoustic power density of 69 mW/mm2.
A Battery/Ultracapacitor Hybrid Energy Storage System for Implementing the Power Management of Virtual Synchronous Generators (2017)

Renewable energy sources (RESs) have been extensively integrated into modern power systems to meet the increasing worldwide energy demand as well as reduce greenhouse gas emission. As a result, the task of frequency regulation previously provided by synchronous generators is gradually taken over by power converters, which serve as the interface between the power grid and RESs. By regulating power converters as virtual synchronous generators (VSGs), they can exhibit similar frequency dynamic response. However, unlike synchronous generators, power converters are incapable of absorbing/delivering any kinetic energy, which necessitates extra energy storage systems (ESSs). Nonetheless, the implementation and coordination control of ESSs in VSGs have not been investigated by previous research. To fill this research gap, this letter proposes a hybrid ESS (HESS) consisting of a battery and an ultracapacitor to achieve the power management of VSGs. Through proper control, the ultracapacitor automatically tackles the fast-varying power introduced by inertia emulation while the battery implements the remaining parts of a VSG and only compensates for relatively long-term power fluctuations with slow dynamics. In this way, the proposed HESS allows reduction of the battery power fluctuations along with its changing rate. Finally, experimental results are presented to validate the proposed concept.
MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension (2012)

Pulmonary hypertension (PH) results in pressure overload of the right ventricle (RV) of the heart, initiating pathological RV remodeling and ultimately leading to right heart failure. Substantial research indicates that signaling through the MAPK superfamily mediates pathological cardiac remodeling. These considerations led us to test the hypothesis that the regulatory protein MAPKKK-2 (MEKK2) contributes to RV hypertrophy in hypoxia-induced PH. Transgenic mice with global knockout of MEKK2 (MEKK2(-/-) mice) and age-matched wild-type (WT) mice were exposed to chronic hypobaric hypoxia (10% O(2), 6 wk) and compared with animals under normoxia. Exposure to chronic hypoxia induced PH in WT and MEKK2(-/-) mice. In response to PH, WT mice showed RV hypertrophy, demonstrated as increased ratio of RV weight to body weight, increased RV wall thickness at diastole, and increased cardiac myocyte size compared with normoxic control animals. In contrast, each of these measures of RV hypertrophy seen in WT mice after chronic hypoxia was attenuated in MEKK2(-/-) mice. Furthermore, chronic hypoxia elicited altered programs of hypertrophic and inflammatory gene expression consistent with pathological RV remodeling in WT mice; MEKK2 deletion selectively inhibited inflammatory gene expression compared with WT mice. The actions of MEKK2 were mediated in part through regulation of the abundance and phosphorylation of its effector, ERK5. In conclusion, signaling by MEKK2 contributes to RV hypertrophy and altered myocardial inflammatory gene expression in response to hypoxia-induced PH. Therapies targeting MEKK2 may protect the myocardium from hypertrophy and pathological remodeling in human PH.
Measurement instrument selection for very high bit rate contactless transponder evaluation (2011)

In this paper we discuss properties of the digital sampling oscilloscope versus signal analyzer as instrument in the test bench to characterize ISO/IEC14443 compliant contactless communication devices. An extension to the existing near-field communication (NFC) standard specifies very high bit rates (VHBR) in the range of 10 Mbit/s for the Reader to Transponder communication link. One draft specification takes advantage of sophisticated signal processing and clever coding, to allow an energy-efficient contactless system, compliant to existing frequency regulation and to typical Reader hardware, which can also be used in mobile applications such as NFC in Smartphones. Considerations for the test bench to characterize this communication air interface are of general interest also for existing RFID standards in the 13.56 MHz frequency band.
Simultaneous profiling of DNA methylation and chromatin architecture in mixed populations and in single cells (2018)

Abstract Dynamic DNA methylation and three-dimensional chromatin architecture compose a major portion of a cell’s epigenome and play an essential role in tissue specific gene expression programs. Currently, DNA methylation and chromatin organization are generally profiled in separate assays. Here, we report Methyl-HiC, a method combining in situ Hi-C and whole genome bisulfite sequencing (WGBS) to simultaneously capture chromosome conformation and DNA methylome in a single assay. Methyl-HiC analysis of mouse embryonic stem cells reveals coordinated DNA methylation between distant yet spatially proximal genomic regions. Extension of Methyl-HiC to single cells further enables delineation of the heterogeneity of both chromosomal conformation and DNA methylation in a mixed cell population, and uncovers increased dynamics of chromatin contacts and decreased stochasticity in DNA methylation in genomic regions that replicate early during cell cycle.
Antimalarial Activity of Cassane- and Norcassane-Type Diterpenes from Caesalpinia crista and Their Structure-Activity Relationship (2006)

Malaria is one of the most life-threatening infectious diseases worldwide and claims millions of people's lives each year. The appearance of drug-resistance Plasmodium falciparum has made the treatment of malaria increasingly problematic, and thus, it is a dire need to search the new alternatives of current drugs. In the present study, 44 cassane- and norcassane-type diterpenes isolated from Caesalpinia crista of Myanmar and Indonesia were evaluated for their antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro. Most of the tested diterpenes displayed antimalarial activity, and norcaesalpinin E (28) showed the most potent activity with an IC50 value of 0.090 microM, more potent than the clinically used drug chloroquine (IC50, 0.29 microM). Based on the observed results, a structure-activity relationship has been established.
Ned/IBV® S.V.E. Diagnóstico y evaluación de patologías del equilibrio humano (2002)

espanolEL INSTITUTO DE BIOMECANICA DE VALENCIA (IBV) ESTA TRABAJANDO EN LA PUESTA A punto de una avanzada tecnica de valoracion funcional de patologias del equilibrio humano basada en las plataformas de fuerzas Dinascan/IBV®. La aplicacion Ned/IBV® S.V.E. combinara pruebas de valoracion de posturografia estatica con pruebas dinamicas de marcha humana para proporcionar al especialista un indice sobre la valoracion final de equilibrio de un paciente, diferenciando las valoraciones en el eje anteroposterior y en el eje mediolateral. Ademas ofrecera un analisis sensorial de los sistemas propioceptivo, visual y vestibular que permitira determinar de una forma rapida el origen de la patologia que afecta al paciente. EnglishThe Institute of Biomechanics of Valencia (IBV) is working on the setting of an advanced technique of functional assessment of balance pathologies based on the Dinascan/IBV® force platforms. Ned/IBV® S.V.E. application will combine static posturography tests with dynamic human walk tests in order to provide the specialist with an index about the final assessment of the balance of the patient, distinguishing between antero-posterior and medio-lateral assessments axes. Besides it will offer a sensorial analysis of the propioceptive, visual and vestibular systems, that will help to determine in a quick way the origin of the pathology that affects the patient.
Performance and computational complexity optimization in configurable hybrid video coding system (2005)

In this paper, a configurable coding scheme is proposed and analyzed with respect to computational complexity and distortion (C-D). The major coding modules are analyzed in terms of computational C-D in the H.263 video coding framework. Based on the analyzed data, operational C-D curves are obtained through an exhaustive search, and the Lagrangian multiplier method. The proposed scheme satisfies the given computational constraint independently of the changing properties of the input video sequence. A technique to adaptively control the optimal encoding mode is also proposed. The performance of the proposed technique is compared with a fixed scheme where parameters are determined by off-line processing. Experimental results demonstrate that the adaptive approach leads to computation reductions of up to 19%, which are obtained with test video sequences and compared to the fixed, while the peak signal-to-noise ratio degradations of the reconstructed video are less than 0.05 dB.
Redox-Modulated Recognition of Flavin by Functionalized Gold Nanoparticles (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRedox-Modulated Recognition of Flavin by Functionalized Gold NanoparticlesAndrew K. Boal and Vincent M. RotelloView Author Information Department of Chemistry University of Massachusetts Amherst, Massachusetts 01003 Cite this: J. Am. Chem. Soc. 1999, 121, 20, 4914–4915Publication Date (Web):May 7, 1999Publication History Received19 February 1999Published online7 May 1999Published inissue 1 May 1999https://pubs.acs.org/doi/10.1021/ja9905288https://doi.org/10.1021/ja9905288rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views944Altmetric-Citations116LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Colloids,Flavins,Gold,Receptors,Redox reactions Get e-Alerts
Identification of an idiotypic peptide recognized by autoantibodies in human immunodeficiency virus-1-infected individuals. (1995)

Antibodies against HIV-1 proteins in HIV-1-infected individuals share a cross-reactive idiotype defined by the monoclonal antiidiotypic antibody 1F7 (5). Using a computer algorithm based on the molecular recognition theory, regions of inverse hydropathy between the variable sequence of 1F7 and human monoclonal anti-HIV-1 antibodies were identified, which are assumed to be involved in idiotype-antiidiotype contacts. A peptide was designed from the proposed contact in the variable heavy chain framework 3-complementarity determining region 3 (FR3-CDR3) of human antibodies and was synthesized. This peptide is recognized by the antiidiotype 1F7 and inhibits the binding of 1F7 to human anti-HIV-1 antibodies which express the 1F7 idiotype. A survey of normal and HIV-1-infected sera revealed the presence of antibodies in infected sera which bind to the FR3-CDR3 peptide. The biological relevance of autoantibodies against a self idiotope associated with HIV-1 infection is discussed in the context of the regulation of the antibody response to HIV-1.
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease (2015)

G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases. However, a lack of pharmacological tools and the absence of convincingly defined endogenous ligands have hampered the understanding of function necessary to exploit it therapeutically. Although several endogenous molecules can activate GPR35 none has yet been confirmed as the key endogenous ligand due to reasons that include lack of biological specificity, non-physiologically relevant potency and species ortholog selectivity. Recent advances have identified several highly potent synthetic agonists and antagonists, as well as agonists with equivalent potency at rodent and human orthologs, which will be useful as tool compounds. Homology modeling and mutagenesis studies have provided insight into the mode of ligand binding and possible reasons for the species selectivity of some ligands. Advances have also been made in determining the role of the receptor in disease. In the past, genome-wide association studies have associated GPR35 with diseases such as inflammatory bowel disease, type 2 diabetes, and coronary artery disease. More recent functional studies have implicated it in processes as diverse as heart failure and hypoxia, inflammation, pain transduction and synaptic transmission. In this review, we summarize the progress made in understanding the molecular pharmacology, downstream signaling and physiological function of GPR35, and discuss its emerging potential applications as a therapeutic target.
On the Eu3+ Fluorescence in Mixed Metal Oxides. III. Energy Transfer in Eu3+-Activated Tungstates and Molybdates of the Type Ln2WO6 and Ln2MoO6 (1966)

The fluorescence of unactivated and rare-earth-activated materials of the type Ln2WO6, Ln2MoO6, and Y2W1−xMoxO6 (0≤x≤0.1) has been studied. From the experiments on unactivated materials it follows that energy transfer from tungstate to tungstate or mobyldate group takes place, whereas there is no transfer from molybdate to molybdate or tungstate group. Arguments in favor of exchange-regulated energy transfer from tungstate or molybdate group to rare-earth ion are put forward. The efficiencies of the rare-earth-activated tungstates and molybdates can be qualitatively understood assuming a strong dependence of the energy transfer on the angle tungsten (molybdenum)—oxygen—rare earth. In Y2W1−xMoxO6:Eu the molybdate group acts as a killer of the fluorescence under short-wave uv excitation and as a sensitizer under long-wave uv excitation.