gebhart/patrepeval huggingface dataset:
Monitoring lung fluid content in CHF patients under intravenous diuretics treatment using bio-impedance measurements (2007)

A pulmonary edema monitoring system (PulmoTrace, CardioInspect, Tel-Aviv University, Israel) was evaluated for tracking lung resistivity during diuretics treatment in congestive heart failure (CHF) patients. The system incorporates a bio-impedance measurement algorithm and enables, by employing an eight-electrode thoracic belt, the assessment of both the left- and right-lung resistivity values. A clinical study was conducted on a group of 13 CHF patients under intravenous diuretics treatment. The group was measured twice-before the beginning of treatment and following a period of a couple of hours. An increase of 8% of the mean lung resistivity (median value) was found between the two measuring sessions, which indicates a dehydration of the lungs, and a significant correlation (R=0.73, p=0.004) was found between the lung resistivity change and the urine output. In conjunction with previously reported results, which demonstrated the system's reproducibility and long-term monitoring capabilities, this study further supports the diagnostics value of the system.
REACTIONS OF β,β'-DICHLORO-ETHYL SULFIDE WITH AMINO COMPOUNDS (1925)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTREACTIONS OF β,β'-DICHLORO-ETHYL SULFIDE WITH AMINO COMPOUNDSWalter E. Lawson and E. Emmet ReidCite this: J. Am. Chem. Soc. 1925, 47, 11, 2821–2836Publication Date (Print):November 1, 1925Publication History Published online1 May 2002Published inissue 1 November 1925https://pubs.acs.org/doi/10.1021/ja01688a028https://doi.org/10.1021/ja01688a028research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experimentally induced parthenogenetic activation of human oocytes (1993)

A total of 486 unfertilized, aged human oocytes were exposed to ethanol, calcium ionophore A23187, phorbol ester or puromycin and examined for evidence of activation. Five per cent of control oocytes (3/58) were spontaneously activated. Of the two agents which cause the release of intracellular Ca2+ ions, Ca2+ ionophore induced activation of only 16% of unfertilized oocytes, while ethanol did not have any effect. Phorbol ester, a stimulator of protein kinase C, also resulted in limited activation (14% of oocytes). In contrast, puromycin, an inhibitor of protein synthesis, resulted in activation of 91% of the exposed oocytes. It is speculated that puromycin probably inhibits a specific cytostatic factor or factors which are responsible for maintenance of the metaphase II block. Morphologically activated oocytes usually retained the second polar body and formed subnuclei. The developmental potential of activated oocytes appeared to be reduced, with only some oocytes capable of a single division.
Virtual endoscopy: from simulation to optimization of an active endoscope (2002)

The design and realization of micro robotic devices in the medical field enable the operating gesture to be assisted. So a polyarticulated device actuated with shape memory alloy (SMA) springs for endoscopy is developed in collaboration with the Laboratoire de Robotique de Paris. In this paper, a simulator realization, based on an original simulation platform (OpenMASK), of this structure is described. A numerical representation of the inspected network obtained by magnetic resonance imaging is used. A contact detection algorithm, which will be described, allows to determine the interaction forces between the endoscope and the duct thanks to a distance cartography of the space, in order to minimize the calculation time. An important experimental work shall be lead to determine the parameters of the contact model. Simulation results of virtual navigation through this duct representation by using an endoscope mechanical model including a behaviour description of the SMA actuators will be presented. Moreover, the efficiency of a command with the multi-agent approach is proved. Then the simulator interest is studied for the prototype amelioration by applying the techniques of virtual prototyping. Some results of optimization by using genetic algorithms with respect to the virtual navigation task will be shown.
Titin: major myofibrillar components of striated muscle. (1979)

Electrophoretic analyses of protein components of striated muscle myofibril purified from various vertebrate and invertebrate species revealed that proteins much larger than myosin heavy chain are present in significant amounts. To define possible roles of these heretofore unidentified proteins, we purified a combination of two uncommonly large proteins, designated as titin, from chicken breast myofibrils. Chemical and immunological studies indicated that titin is distinct from myosin, actin, and filamin. Specific titin anti body crossreacts with similar protein in both skeletal and cardiac myofibrils of many vertebrate and invertebrate species. Immunofluorescent staining of glycerinated chicken breast myofibrils indicated that titin is present in M lines, Z lines, the junctions of A and I bands, and perhaps throughout the entire A bands. Similar staining studies of myofibrils from other species suggest that titinlike proteins may be organized in all myofibrils according to a common architectural plan. We conclude that titin is a structurally conserved myofibrillar component of vertebrate and invertebrate striated muscles.
Application-level QoS assessment of continuous media multicasting in a wireless ad hoc network (2004)

This paper assesses the application-level QoS of live audio and video multicasting in a wireless ad hoc network. We regard the quality of media synchronization as the major part of the application-level QoS. We also investigate the inter-destination synchronization quality of three schemes: the master-slave destination scheme, the synchronization maestro scheme, and the distributed control scheme. The inter-destination synchronization adjusts the output timing among destinations in a multicast group. We perform computer simulation with a string topology network. In the simulation, a source terminal multicasts the media streams to six destinations by using ODMRP (on-demand multicast routing protocol), which is a multicast routing protocol for ad hoc networks. The simulation result shows that the master-slave destination scheme, which sends smaller numbers of control packets for inter-destination synchronization control than the other two schemes, provides higher quality of application-level QoS; however, the QoS of this scheme is sensitive to the location of the master destination. When it is difficult to find an appropriate destination for the master, the synchronization maestro scheme can be the second best choice.
Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro (1998)

Surface enhanced Raman spectroscopy (SERS) at a silver microelectrode was used to monitor bacterial hydrolysis of triglycerides in lipid mixtures that model sebaceous gland secretions. Mixtures of wax esters, squalene, triolein, and triisostearin were used as model skin secretions. The transformation was followed in vitro as changes in the SERS caused by hydrolysis of triglyceride to fatty acid. The fatty acid was adsorbed as its carboxylate, which is readily identified by the characteristic band at ca. 1395 cm(-1). Co-adsorption of propionate was also observed. The technique can also confirm the presence of bacteria by detection of short chain carboxylic acids released as products of fermentation during the growth of these cells.
The relationship between pro-inflammatory cytokines and pain, appetite and fatigue in patients with advanced cancer (2017)

In patients with advanced cancer and pain, some pro-inflammatory cytokines were related to appetite and fatigue. Inflammatory biomarkers were not associated with pain or with the efficacy of corticosteroid therapy. Further research examining the attenuation of the systemic inflammatory response and possible effects on symptoms would be of interest.
Effect of very thin Cr-underlayer on the magnetic and recording properties of CoCrTa thin-film media (1994)

A process has been developed which uses very thin Cr-underlayer for CoCrTa-media for high-density recording. The media sputtered using this technique revealed that by decreasing Cr-underlayer thickness from 2000 /spl Aring/ to 200 /spl Aring/, orientation-ratio increased from 1.27 to 1.6, squareness-ratio increased from 0.81 to 0.86, and Mrt increased from 3.25 to 3.97 memu/cm/sup 2/. The Mr value is increased because of the higher squareness. The higher Mr gives a higher Mrt product which produced higher signal output by about 10%. Also, the noise performance was comparable for the media with thin and thick Cr-underlayers. X-ray diffraction patterns showed strong in-plane preferred orientations, Cr(200) and Co(112~0) textures as a function of Cr-underlayer thickness.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The use of elemental diets during cancer therapy (review). (1984)

The intestinal mucosa depends upon luminal contents for part of its own supply of nutrients. Such nutrients are provided in a rapidly available state by elemental diets composed of chemically defined products containing nutrients in their simplest forms, e.g. amino acids, oligopeptides, essential fatty acids, triglycerides and simple sugars. These diets help to maintain the integrity of the intestinal mucosa under conditions such as abdominal irradiation and cancer chemotherapy which greatly impair the terminal digestion of nutrients in the intestinal brush border. The elemental diets also diminish the concentration of potentially injurious constituents of the intestinal juice, such as pancreatic proteases and bile salts, which play an important role in the intestinal complications of cancer therapy.
A comprehensive evaluation of full reference image quality assessment algorithms (2012)

Recent years have witnessed a growing interest in developing objective image quality assessment (IQA) algorithms that can measure the image quality consistently with subjective evaluations. For the full reference (FR) IQA problem, great progress has been made in the past decade. On the other hand, several new large scale image datasets have been released for evaluating FR IQA methods in recent years. Meanwhile, no work has been reported to evaluate and compare the performance of state-of-the-art and representative FR IQA methods on all the available datasets. In this paper, we aim to fulfill this task by reporting the performance of eleven selected FR IQA algorithms on all the seven public IQA image datasets. Our evaluation results and the associated discussions will be very helpful for relevant researchers to have a clearer understanding about the status of modern FR IQA indices. Evaluation results presented in this paper are also online available at http://sse.tongji.edu.cn/linzhang/IQA/IQA.htm.
Synthesis of N-[2-(2-methylpropoxy)ethyl]-N-{2-[(4-methoxy) phenylmethylthio]phenyl}-1-pyrrolidineethanamine (E)-2-butenedioate (1:1) salt (CERM 12816): a potential anti-anginal drug (1998)

CERM 12816, which was required for metabolic studies, was labelled with [14C] in the methylene carbon of the benzyl group. This involved eight steps starting from barium [14C] carbonate and 4-methoxyphenylmagnesium bromide, with a 20% overall yield. The specific activity was 208 MBq mmol−1 (5.6 mCi mmol−1). © 1998 John Wiley & Sons, Ltd.
SYNTHESIS AND SOLVATOCHROMIC PROPERTIES OF 5-DICYANOVINYL-AND 5-TRICYANOVINYL-SUBSTITUTED 2-AMINO-THIAZOLES AND 2-AMINO-THIOPHENES (1999)

Abstract Starting from 2-morpholinothiazoles 6 and 2-morpholinothiophenes 7 and following known routes several 5-dicyanovinyl and 5-tricyanovinyl-substituted derivatives 10–13 have been prepared and their solvatochromic properties estimated. Key Words: 2-Amino-5-(2,2-dicyanoethenyl)thiazoles2-Amino-5-(1,2,2-tricyanoethenyl)-thiazoles2-Amino-5-(2,2-dicyanoethenyl)thiophenes2-Amino-5-(1,2,2-tricyanoethenyl)-thiophenesSolvatochromism
High-resolution multicontrast tomography with an X-ray microarray anode–structured target source (2021)

Multicontrast X-ray imaging with high resolution and sensitivity using Talbot-Lau interferometry (TLI) offers unique imaging capabilities that are important to a wide range of applications, including the study of morphological features with different physical properties in biological specimens. The conventional X-ray TLI approach relies on an absorption grating to create an array of micrometer-sized X-ray sources, posing numerous limitations, including technical challenges associated with grating fabrication for high-energy operations. We overcome these limitations by developing a TLI system with a microarray anode-structured target (MAAST) source. The MAAST features an array of precisely controlled microstructured metal inserts embedded in a diamond substrate. Using this TLI system, tomography of a Drum fish tooth with high resolution and tri-contrast (absorption, phase, and scattering) reveals useful complementary structural information that is inaccessible otherwise. The results highlight the exceptional capability of high-resolution multicontrast X-ray tomography empowered by the MAAST-based TLI method in biomedical applications.
“The Good, the Bad and the Ugly” of Chitosans (2016)

The objective of this paper is to emphasize the fact that while consistent interest has been paid to the industrial use of chitosan, minor attention has been devoted to spread the knowledge of a good characterization of its physico-chemical properties. Therefore, the paper attempts to critically comment on the conflicting experimental results, highlighting the facts, the myths and the controversies. The goal is to indicate how to take advantage of chitosan versatility, to learn how to manage its variability and show how to properly tackle some unexpected undesirable features. In the sections of the paper various issues that relate chitosan properties to some basic features and to advanced solutions and applications are presented. The introduction outlines some historical pioneering works, where the chemistry of chitosan was originally explored. Thereafter, particular reference is made to analytical purity, characterization and chain modifications. The macromolecular characterization is mostly related to molecular weight and to degree of acetylation, but also refers to the conformational and rheological properties and solution stability. Then, the antimicrobial activity of chitosan in relation with its solubility is reviewed. A section is dedicated to the formulation of chitosan biomaterials, from gel to nanobeads, exploring their innovative application as active carrier nanoparticles. Finally, the toxicity issue of chitosan as a polymer and as a constructed nanomaterial is briefly commented in the conclusions.
Cell labeling with magnetic and non magnetic immunomicrospheres for separation and diagnosis (1984)

Abstract
SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity <i>in vivo</i> (2009)

The MET receptor tyrosine kinase has emerged as an important target for the development of novel cancer therapeutics. Activation of MET by mutation or gene amplification has been linked to kidney, gastric, and lung cancers. In other cancers, such as glioblastoma, autocrine activation of MET has been demonstrated. Several classes of ATP-competitive inhibitor have been described, which inhibit MET but also other kinases. Here, we describe SGX523, a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L and is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. Crystallographic study revealed that SGX523 stabilizes MET in a unique inactive conformation that is inaccessible to other protein kinases, suggesting an explanation for the selectivity. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases, including the closely related RON, even at micromolar concentrations. SGX523 inhibition of MET in vivo was associated with the dose-dependent inhibition of growth of tumor xenografts derived from human glioblastoma and lung and gastric cancers, confirming the dependence of these tumors on MET catalytic activity. Our results show that SGX523 is the most selective inhibitor of MET catalytic activity described to date and is thus a useful tool to investigate the role of MET kinase in cancer without the confounding effects of promiscuous protein kinase inhibition.
Digestion of Wool Keratin by Papain-Bisulphite-Urea and Related Systems (1952)

The digestion of wool in papain-bisulphite solutions is greatly enhanced by the addition of urea, t reaching completion within a few hours at 500 or 70°C. Both wool digestion and uptake of papain by wool from urea solutions proceed optimally at pH 7.
Stereoselective Addition of the Titanium Enolate of <i>N</i>-Acetyl (4<i>S</i>)-Isopropyl-1,3-thiazolidine-2-thione to Five-Membered <i>N</i>-Acyl Iminium Ions (2005)

[reaction: see text] Addition of the chlorotitanium enolate of N-acetyl 4-isopropyl-1,3-thiazolidine-2-thione to five-membered, N-substituted N-acyl iminium ions furnished the corresponding Mannich-type addition products with good diastereoselectivity and in good yields. The synthetic utility of the addition product 8 was demonstrated in a chemospecific anti-aldol reaction with cinnamaldehyde. By using this strategy, we constructed three contiguous chiral centers with high stereocontrol employing the same chiral auxiliary. X-Ray crystallographic analysis of addition product 2 and aldol product 14 revealed their absolute stereochemistry.
Subsecond Timing in Primates: Comparison of Interval Production Between Human Subjects and Rhesus Monkeys (2009)

This study describes the psychometric similarities and differences in motor timing performance between 20 human subjects and three rhesus monkeys during two timing production tasks. These tasks involved tapping on a push-button to produce the same set of intervals (range of 450 to 1,000 ms), but they differed in the number of intervals produced (single vs. multiple) and the modality of the stimuli (auditory vs. visual) used to define the time intervals. The data showed that for both primate species, variability increased as a function of the length of the produced target interval across tasks, a result in accordance with the scalar property. Interestingly, the temporal performance of rhesus monkeys was equivalent to that of human subjects during both the production of single intervals and the tapping synchronization to a metronome. Overall, however, human subjects were more accurate than monkeys and showed less timing variability. This was especially true during the self-pacing phase of the multiple interval production task, a behavior that may be related to complex temporal cognition, such as speech and music execution. In addition, the well-known human bias toward auditory as opposed to visual cues for the accurate execution of time intervals was not evident in rhesus monkeys. These findings validate the rhesus monkey as an appropriate model for the study of the neural basis of time production, but also suggest that the exquisite temporal abilities of humans, which peak in speech and music performance, are not all shared with macaques.
Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines (1986)

Substituent effects governing inhibition of DNA polymerase III from Bacillus subtilis were examined in several series of N6-substituted 6-aminopyrimidines. The presence of alkyl groups as large as n-butyl in the 3-position of 6-(5-indanylamino)uracil had no effect on inhibitor-enzyme binding. Substituents in the 4-position of a series of 2-amino-6-(benzylamino)pyrimidines had complex effects: alkoxy and phenoxy derivatives were less active than the parent 4-oxo (isocytosine) compound, but alkylphenoxy and halophenoxy derivatives were more active than the 4-phenoxy compound itself, suggesting that hydrophobic binding can occur between 4-substitutents and the enzyme surface and that space between the pyrimidine ring and pol III may represent the active site of the enzyme. Replacement of 5-H by methyl and ethyl groups drastically decreased inhibitory activity of 6-(benzylamino)- and 6-p-toluidinouracils, but 5-bromo and 5-iodo analogues were equipotent with the parent compounds. These results indicate that the phenyl rings of these compounds must exist in conformations in which they are perpendicular to the pyrimidine ring plane and that charge-transfer stabilization of such "active conformations" may compensate for steric barriers from 5-halo groups in the inhibitor-enzyme complex.
Differences in Susceptibility and Physiological Fitness of Mexican Field Trichoplusia ni Strains Exposed to Bacillus thuringiensis (2006)

The use of different commercial Bacillus thuringiensis (Bt) products in the Bajio guanajuatense area in Mexico began 12 yr ago, and resistance to Bt in this area has been reported for Plutella xylostella (L.) The current study provides a baseline response and resistance potential to Bt in field and laboratory strains of Bajio Trichoplusia ni (Hübner). Differences in susceptibility to Bt among T. ni populations were observed. T. ni neonates collected in Romita, Guanajuato, were more susceptible to Bt than those collected in Salvatierra or San Luis de la Paz, Guanajuato. After five generations of exposure to XenTari in the laboratory, decreased susceptibility was found only in the Salvatierra insects, with an LC50 that was 2.1-fold greater than that of a Mexican laboratory strain. The XenTari-selected San Luis de la Paz strain was from 16- to 87-fold more resistant to Cry1A protoxins than U.S. (US) and Mexican laboratory strains. Although Cry1Ab is not a component of XenTari, this strain also was significantly less susceptible to Cry1Ab toxin compared with a US strain, with a resistance ratio of 40.4. The larval weights and lengths, pupal lengths, and percentage of pupation were significantly lower for the Salvatierra strain than for all other strains. The relationship of T. ni susceptibilities to Bt Cry toxins and protoxins after several generations of exposure to XenTari and its similarity to P. xylostella behavior.
How Do Charges Travel through DNA?—An Update on a Current Debate (1999)

The effects of oligonucleotide sequence, base pairing, stacking, and duplex microstructure as well as donor-acceptor distance, labeling site, and driving force on charge-transfer reactions in DNA are of interest, yet relatively few experiments have been performed to address many of these issues. This article summarizes recent results on DNA-mediated charge transfer and highlights experimental and theoretical issues that are still unanswered or unresolved.