gebhart/patrepeval huggingface dataset:
A Synergistic, Balanced Antioxidant Cocktail, Protects Aging Rats from Insulin Resistance and Absence of Meal-Induced Insulin Sensitization (AMIS) Syndrome (2015)

A series of in vivo and in vitro studies using animal and human models in the past 15 years have demonstrated that approximately 55% (~66% in humans) of the glucose disposal effect of an i.v. injection of insulin in the fed state is dependent on the action of a second hormone, hepatic insulin sensitizing substance (HISS), which is released from the liver and stimulates glucose uptake in muscle, heart and kidneys. Sensitization of the insulin response by a meal through release of HISS is called meal-induced insulin sensitization (MIS). Absence of HISS action results in postprandial hyperglycemia, hyperinsulinemia, hyperlipidemia, adiposity, increased free radical stress and a cluster of progressive metabolic and cardiovascular dysfunctions referred to as the AMIS (absence of meal-induced insulin sensitization) syndrome. Reduced HISS release accounts for the insulin resistance that occurs with aging and is made worse by physical inactivity and diets high in sucrose or fat. This brief review provides an update of major metabolic disturbances associated with aging due to reduction of HISS release, and the protection against these pathological changes in aging animals using a balanced synergistic antioxidant cocktail SAMEC (S-adenosylmethionine, vitamins E and C). The synergy amongst the components is consistent with the known benefits of antioxidants supplied by a mixed diet and acting through diverse mechanisms. Using only three constituents, SAMEC appears suitable as an antioxidant specifically targeting the AMIS syndrome.
The efficacy and safety of bupropion sustained-release formulation for the treatment of major depressive disorder: a multi-center, randomized, double-blind, placebo-controlled study in Asian patients (2013)

This study was conducted to compare the efficacy and safety of bupropion sustained-release (SR) formulation orally administered at daily doses of 150 mg/day (once daily) and 300 mg/day (150 mg twice daily) for 8 weeks versus placebo in Asian patients with major depressive disorder. The mean change from baseline in Montgomery-Åsberg Depression Rating Scale (MADRS) total score at week 8 was compared between each of the bupropion SR dose groups and the placebo group using an analysis of covariance with the multiplicity adjustment by Dunnett's step-down procedure. A total of 569 subjects met all of the inclusion criteria and proceeded to the treatment phase. The subjects proceeding to the treatment phase included 454 Japanese patients and 115 Korean patients. There was no statistically significant difference between each of the bupropion SR dose groups and the placebo group in the primary efficacy endpoint of change from baseline in MADRS total score at week 8. Similar results were generally obtained for all of the secondary efficacy endpoints. The secondary analysis and the other subgroup analysis did not show a statistically significant difference in efficacy. There was no substantial difference in the type, severity, and incidence of adverse events (AEs) between the bupropion SR dose groups and the placebo group, which indicates a favorable safety profile for bupropion SR. There were no significant findings in subjects treated with bupropion SR in regard to sexual dysfunction, weight change, and withdrawal syndrome, which are frequently recognized as clinical concerns associated with selective serotonin reuptake inhibitors, widely used for the treatment of depression.
Information sharing behavior prediction of online social network users (2013)

Information transmission paths in online social networks(OSN) contain users' preferences as information content and source.This paper proposed a method based on the information paths to predict the information sharing behavior of OSN users.Firstly studied the transform method of the information transform process to information transform paths based on information filtrate ability of these paths.Then,used an association rules based classification algorithm to predict the information sharing behavior of users.It used an empirical research of Sina Weibo to test the prediction method.Results show that it works well when predict the information sharing behavior of active uses on OSNs.
A Guide to the Aquaponics Food Safety Plan Development: Green Aquaponics LLC as a Model (2019)

Virginia Cooperative Extension provides a variety of educational publications and other resources related to Agriculture, Communities, Leadership, Families, Food, Health, Gardening, Natural Resources, Youth, and 4-H.
Imidazolium-Based Porous Organic Polymers: Anion Exchange-Driven Capture and Luminescent Probe of Cr<sub>2</sub>O<sub>7</sub><sup>2–</sup> (2016)

A series of imidazolium-based porous organic polymers (POP-Ims) was synthesized through Yamamoto reaction of 1,3-bis(4-bromophenyl)imidazolium bromide and tetrakis(4-bromophenyl)ethylene. Porosities and hydrophilicity of such polymers may be well tuned by varying the ratios of two monomers. POP-Im with the highest density of imidazolium moiety (POP-Im1) exhibits the best dispersity in water and the highest efficiency in removing Cr2O7(2-). The capture capacity of 171.99 mg g(-1) and the removal efficiency of 87.9% were achieved using an equivalent amount of POP-Im1 within 5 min. However, no Cr2O7(2-) capture was observed using nonionic analogue despite its large surface area and abundant pores, suggesting that anion exchange is the driving force for the removal of Cr2O7(2-). POP-Im1 also displays excellent enrichment ability and remarkable selectivity in capturing Cr2O7(2-). Cr(VI) in acid electroplating wastewater can be removed completely using excess POP-Im1. In addition, POP-Im1 can serve as a luminescent probe for Cr2O7(2-) due to the incorporation of luminescent tetraphenylethene moiety.
The Effect of Itraconazole on Aortic Histophatology in Hyperlipidemic Rabbits (2014)

Atherosclerosis is a chronic inflammatory disease and begins with the dysfunction of the endothelial layer of the vessels and continues to change the nature of the area beneath Intima and accumulation of lipoproteins in this area. Itraconazole, with a wide range of antifungal features, has important attributes such as anti-inflammatory activity, its inhibitory effect on the activity of 5-lipoxygenase and effect of the chemotaxis of T-Cell. 40 rabbits were divided into 4 equal groups. The first group were fed normal diet, second group was fed highcholesterol diet, the third group was fed with normal food and itraconazole drug and the fourth group was fed high-cholesterol diet and itraconazole and at the end of the twelfth week, the animals were anesthetized and aortic samples were taken, and information was studied after coloring. The mean size of the inner, middle and the adventitia of the aorta layers at the end of the twelfth week in the fourth and second groups were increased compared to control group, this increase was more obvious in the second group while it was reduced in the third group. In the second group at the end of the twelfth week a mass of foamy cells in the Intima layer was observed,while in the fourth group the amount was little and dispersed. Layers reduction of the aorta in the third group and also the fourth group compared to the second group can be caused by anti-inflammatory feature and antioxidant effects of itraconazole that avoid transient increase in blood fats after meal, which is highly atherogenic. Itraconazole drug affects the endothelial layer performance.
A screening for BRCA1 mutations in breast and breast-ovarian cancer families from the Stockholm region. (1997)

To identify BRCA1 germ-line mutations in the breast and breast-ovarian cancer families in the Stockholm region, a total of 127 families were screened. DNA from 174 patients from these families were studied using various mutation screening techniques, followed by direct DNA sequencing. Mutations were identified in 7 of 20 families with breast and ovarian cancer and in one family with ovarian cancer only, whereas only 1 family of 106 with breast cancer showed a mutation. Thus, germ-line mutations in BRCA1 were found in one-third of the families with both breast and ovarian cancer, but in only 1% of the breast cancer families. The low frequency of germ-line mutations in the site-specific breast cancer families means that other genes are likely to segregate in these families.
Flocculants (2000)

Abstract The article contains sections titled: 1. Introduction 2. Classification of Flocculants 2.1. Inorganic Flocculants 2.2. Natural Organic Flocculants 2.3. Synthetic Organic Flocculants 2.3.1. Chemical Structure 2.3.2. Production Requirements 3. Flocculation Mechanisms 3.1. Double Layer Compression 3.2. Specific Ion Adsorption 3.3. Polymer Charge Patch 3.4. Polymer Bridging 4. Uses 5. Choice of Optimum Flocculant 6. Legal Aspects 7. Economic Aspects
A Thermodynamic Study of 1:1 Complex Formation between N-Methyl Lactams and Phenol in Carbon Tetrachloride<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Thermodynamic Study of 1:1 Complex Formation between N-Methyl Lactams and Phenol in Carbon Tetrachloride1C. D. Schmulbach and David M. HartCite this: J. Org. Chem. 1964, 29, 10, 3122–3124Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://pubs.acs.org/doi/10.1021/jo01033a539https://doi.org/10.1021/jo01033a539research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
KINETICS OF MODULATORY ROLE OF Cyperus esculentus L. ON THE SPECIFIC ACTIVITY OF KEY CARBOHYDRATE METABOLIZING ENZYMES (2017)

The respective competitive and non-competitive mode of action of the extract is due to its inhibitory potentials on the activities of <i>α</i>-amylase and <i>α</i>-glucosidase. Going forward, in addition to completely characterize the exact compound(s) responsible for the elicited activity in this study, pertinent attention will be given to the <i>in vivo</i> evaluation of the identified constituents.
Acute hepatitis due to buprenorphine administration (2004)

Although buprenorphine hepatitis is uncommon and has spontaneously good evolution, we suggest better monitoring of hepatic profiles in patients whose mitochondrial function is already impaired by viral infections or other toxic factors.
Studies on aromatic nitro compounds. V. A simple one-pot preparation of o-aminoaroylnitriles from some aromatic nitro compounds. (1985)

The reactions of 3-, 5-, 6-, 7- and 8-nitroquinolines, 1-or 2-nitronaphthalene and m-substituted (CF3, COCH3 and COC6H5) nitrobenzenes with ethyl cyanoacetate and potassium hydroxide in dimethylformamide, followed by hydrolysis of the reaction mixture with hydrochloric acid or sodium hydroxide, gave the corresponding o-aminoaroylnitriles.
Force Constant of the Association Bond in the Formic and Acetic Acid Dimers (1946)

The entropies of the formic and acetic acid dimers are used to find a minimum value for the force constant of the association bond. With the aid of a normal coordinate treatment the probable value is found to be 4×104 dynes/cm. This agrees with a rough estimate from the heat of dimerization. A Raman band in the formic acid spectrum at 200 cm−1 may be due to the association vibrations.
An Integrated Strategy for Evaluation of Metabolic and Oxidative Defects in Neurodegenerative Illness Using Magnetic Resonance Techniques (1999)

The number of physiologic and metabolic phenomena amenable to analysis using magnetic resonance (MR) techniques is increasing every year. MR techniques can now evaluate tissue parameters relevant to TCA cyclemetabolism, anerobic glycolysis, ATP levels, blood-brain barrier permeability, macrophage infiltration, cytotoxic edema, spreading depression, cerebral blood flow and volume, and neurotransmitter function. The paramagnetic nature of certain oxidation states of iron leads to the ability to map out brain function using deoxyhemoglobin as an endogenous contrast agent, and also allows for mapping of local tissue iron concentrations. In addition to these metabolic parameters, the number of ways to generate anatomic contrast using MR is also expanding; and in addition to conventional anatomic scans, mapping of axonal fiber tracts can also be performed using the anisotropy of water diffusion. A strategy for integration of these multifarious parameters in a comprehensive neurofunctional exam in neurodegenerative illness is outlined in this paper. The goals of the integrated exam, as applied to a given neurodegenerative illness, can be subdivided into three categories: etiology, natural history, and therapeutic end points. The consequences of oxidative stress and/or mitochondrial dysfunction are explored in the context of the various parameters that can be measured using the integrated MR exam.
Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies (2003)

These data do not support the hypothesis that cancer risk in mothers and offspring of preeclamptic pregnancies is explained by exposure to lower maternal blood oestrogen concentrations, but raise the possibility that androgens play a role.
Transistor sizing for reliable domino logic design in dual threshold voltage technologies (2001)

Dynamic logic is much susceptible to noise specially in ul tra deep submicron technology The keeper transistor has to be carefully sized to maintain noise margin without much speed penalty In this paper we analyze the keeper tran sistor sizing with respect to the size of NMOS transistors in the evaluation tree Based on the analytical results we propose a keeper transistor sizing method HSPICE simula tion results show that the proposed keeper transistor sizing method can be broadly applied to all domino logic gates
Dual n-back training improves functional connectivity of the right inferior frontal gyrus at rest (2020)

Several studies have shown that the benefits of working memory (WM) training can be attributed to functional and structural neural changes in the underlying neural substrate. In the current study, we investigated whether the functional connectivity of the brain at rest in the default mode network (DMN) changes with WM training. We varied the complexity of the training intervention so, that half of the participants attended dual n-back training whereas the other half attended single n-back training. This way we could assess the effects of different training task parameters on possible connectivity changes. After 16 training sessions, the dual n-back training group showed improved performance accompanied by increased functional connectivity of the ventral DMN in the right inferior frontal gyrus, which correlated with improvements in WM. We also observed decreased functional connectivity in the left superior parietal cortex in this group. The single n-back training group did not show significant training-related changes. These results show that a demanding short-term WM training intervention can alter the default state of the brain.
Production of sensitive converter screens for thermal neutron diffraction patterns (1972)

A simple procedure is given for the production of thermal neutron converter screens. The performance of these and commercial screens have been compared for neutrons of 1 Å wavelength. Diffraction patterns have been taken.
Brain metastases in HER2-overexpressing metastatic breast cancer: Comparative analysis of trastuzumab levels in serum and cerebrospinal fluid (2006)

1525 Purpose: Patients receiving trastuzumab for HER2-overexpressing MBC suffer from an increased risk to develop BM despite responsive visceral disease. The present pilot study was conducted to explore trastuzumab levels in S and CSF of MBC patients afflicted with BM, and to evaluate whether radiotherapy will lead to impairment the blood-brain barrier (BBB) to allow penetration of trastuzumab into CSF. Methods: Patients with BM from HER2-overexpressing MBC (IHC; DAKO Hercep Test) were included. Trastuzumab levels in S and CSF were determined at different time points by a newly developed immunoenzymatic test for functional, reactive trastuzumab. Results: Six out of 8 eligible patients were evaluable. Prior to whole-brain radiotherapy (WBRT), the median trastuzumab serum level was 52,054 ng/ml compared to a median CSF level of 124 ng/ml (ratio 420:1). After completion of WBRT, the median level of trastuzumab was 20,185 ng/ml in serum and 226 ng/ml in CSF (ratio 76:1). In two cases of concomitant meningeal carcinomatosis, the median serum level of trastuzumab after WBRT was 17,431 ng/ml and 356 ng/ml in CSF (ratio 49:1). Conclusion: These data indicate that the BBB prevent trastuzumab to reach adequate concentrations in CSF. These levels are increased under conditions of an impaired BBB, as is known for meningeal carcinomatosis and for patients receiving WBRT. The new test system in this pilot study provides the basis for the evaluation of radiotherapeutic strategies which allow most favorable penetration of trastuzumab into the CNS in patients receiving concomitant trastuzumab for HER2-overexpressing metastatic breast cancer. [Table: see text]
Effect of Operating Valve Performance on Stability of Gas Lift Wells (2005)

Abstract Heading (flow instability) is a common problem in the operation of continuous flow gas-lift wells. One of the key elements, which affect the gas-lift stability, is the operating valve. Several operating gas-lift valve designs are currently used in practice. A new valve design, based on the use of a supersonic nozzle ("the nozzle-Venturi gas-lift valve"), was recently proposed in the literature. In most cases, it is very difficult to estimate apriori (at the design stage) how the type of the gas-lift valve and its design parameters affect the stability of a gas-lift system to be operated at a given operating condition. In this paper, the effect of operating valve design on gas-lift stability was studied. It is shown that the gas-lift stability maps proposed in an earlier study may facilitate the selection of the operating valve design. Different valve designs were considered: the conventional orifice and gas-lift valves, as well as the nozzle-Venturi valve. Gas-lift stability maps were constructed for each operating valve design. Advantages and disadvantages of the considered valve types are discussed from the point of view of the gas-lift stability. Based on the comparison of the gas-lift stability maps, recommendations on the selection of the operation valve type were elaborated.
The social networks of seriously mentally ill persons receiving case management services. (1994)

Social network characteristics, or the patterning of one's social ties, are an important indicator of social support for persons with serious mental illness. Yet relatively few studies have been done on the particular network characteristics of clients receiving case management services in community settings. An understanding of the range of potential and actual social network contacts for persons with serious mental illness is important for targeting interventions to enhance their community supports. In this study, 125 clients of two urban community treatment teams were surveyed by case managers to determine their overall social network size, personal or support network size, and participation in any of 11 network clusters. Results of the study are presented with implications for the social functioning of persons with serious mental illness and suggestions for case manager interventions toward network expansion.
A SIMPLIFIED ROUTE TO A KEY INTERMEDIATE IN THE TOTAL SYNTHESIS OF RESERPINE (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA SIMPLIFIED ROUTE TO A KEY INTERMEDIATE IN THE TOTAL SYNTHESIS OF RESERPINER. B. Woodward, F. E. Bader, H. Bickel, A. J. Frey, and R. W. KiersteadCite this: J. Am. Chem. Soc. 1956, 78, 11, 2657Publication Date (Print):June 1, 1956Publication History Published online1 May 2002Published inissue 1 June 1956https://pubs.acs.org/doi/10.1021/ja01592a102https://doi.org/10.1021/ja01592a102research-articleACS PublicationsRequest reuse permissionsArticle Views1816Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrospray Deposition, Model, and Experiment:  Toward General Control of Film Morphology (2006)

Poly(vinylidene fluoride) film formation with electrospray deposition has been studied with support of a droplet evaporation model. The input parameters of the model consist basically of the solvent, the solute concentration, the flow rate, and the solution conductivity. The model provides the droplet size, the solute concentration, the droplet velocity, and the shear stress of the droplet at impact as a function of the distance between the nozzle and the substrate. With some additional experimental information such as the size change of the film with spray distance and the viscosity of the solution, the growth rate of the film and the shear rate of the droplet at impact can be determined. Growth rate is shown to define distinct regimes of film formation. In those regimes, only a single factor or a limited number of factors controls the film morphology. The most important factors include the shear rate and the surface energy. It is found that at a specific range of growth rates only the shear rate determines the morphology of the polymer film. Growth rate, as the defining quantity of film morphology, is not limited to polymer solutions. Therefore, the growth rate, in combination with the control factors mentioned above, functions as a general framework through which understanding and control of film formation with electrospray deposition can be improved.