gebhart/patrepeval huggingface dataset:
Morphological characterisation of the cell-growth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as an oral prodrug for cancer therapy. (1995)

Hypoxoside is the major diglucoside isolated from the corms of the plant family Hypoxidaceae. It contains an unusual E-pent-1-en-4-yne 5-carbon bridging unit with two distal catechol groups to which the glucose moieties are attached. It is non-toxic for BL6 mouse melanoma cells in tissue culture on condition that the fetal calf serum in the medium is heat-inactivated for 1 hour at 56 degrees C in order to destroy endogenous beta-glucosidase activity. The latter catalyses hypoxoside conversion to its cytotoxic aglucone, rooperol, which, when tested as a pure chemical, caused 50% inhibition of BL6 melanoma cell growth at 10 micrograms/ml. Light and electron microscopy revealed that the cytotoxic effect of rooperol manifested as vacuolisation of the cytoplasm and formation of pores in the plasma membrane. Indications of apoptosis were also found. Pharmacokinetic studies on mice dosed intragastrically with hypoxoside showed that it was deconjugated by bacterial beta-glucosidase to form rooperol in the colon. Surprisingly, no hypoxoside or rooperol was detectable in the serum. Only phase II biotransformation products (sulphates and glucuronides) were present in the portal blood and bile. In contrast, however, in human serum after oral ingestion of hypoxoside, the metabolites can reach relatively high concentrations. Rooperol metabolites isolated from human urine were non-toxic for BL6 melanoma cells in culture up to a concentration of 200 micrograms/ml. In the presence of beta-glucuronidase, which released rooperol from the metabolites, 50% growth inhibition was achieved at a 75 micrograms/ml metabolite concentration. The supernatant of a human melanoma homogenate could also cause deconjugation of the metabolites to form rooperol.(ABSTRACT TRUNCATED AT 250 WORDS)
Structure and metrology for a single-wire analog testability bus (2002)

A structure for testing the interconnect faults and measurement of discrete components on mixed-signal boards is proposed. The structure requires one analog pin in addition to the IEEE 1149.1 pins on each mixed-signal IC. Simulation results are provided to show the accuracy of the metrology.
Chaotic and bifurcation behaviour in an autonomous flip-flop circuit using piecewise linear tunnel diodes (2002)

A circuit realization of an autonomous flip-flop circuit using piecewise linear tunnel diodes, producing chaotic and bifurcation behaviour, is proposed. The proposed circuit is made of four linear passive element (2 capacitors, 1 inductor, 1 resistor), one active element (1 DC battery) and two piecewise linear characteristic nonlinear resistors realized by using an operational amplifier. Typical global behaviour in the circuit is illustrated. By using an analysis of the one-dimensional Poincare map constructed from experimental data, chaotic behaviour is examined, and the Liapunov exponents are estimated. The experimental observations are compared with the digital computer simulations.
Hamburg (1986)

Mit dem Schlagwort „Hamburg — Tor zur Welt“, das aus dem Wappen der Freien und Hansestadt abgeleitet ist, verbindet sich für jedermann der Gedanke an die Atmosphäre des Hafens, dem Hamburg auch heute noch seinen besonderen Charakter verdankt. Wirtschaft und Verkehr der Stadt wurden bis zum Ende des 19. Jahrhunderts fast ausschließlich durch die Seeschiffahrt geprägt. Hamburg erlangte Weltgeltung als inernationales Handelszentrum.
Can I Take Your Subdomain? Exploring Related-Domain Attacks in the Modern Web (2020)

Related-domain attackers control a sibling domain of their target web application, e.g., as the result of a subdomain takeover. Despite their additional power over traditional web attackers, related-domain attackers received only limited attention by the research community. In this paper we define and quantify for the first time the threats that related-domain attackers pose to web application security. In particular, we first clarify the capabilities that related-domain attackers can acquire through different attack vectors, showing that different instances of the related-domain attacker concept are worth attention. We then study how these capabilities can be abused to compromise web application security by focusing on different angles, including: cookies, CSP, CORS, postMessage and domain relaxation. By building on this framework, we report on a large-scale security measurement on the top 50k domains from the Tranco list that led to the discovery of vulnerabilities in 887 sites, where we quantified the threats posed by related-domain attackers to popular web applications.
Estimating neural networks-based algorithm for adaptive cache replacement (1998)

In this paper, we propose an adaptive cache replacement scheme based on the estimating type of neural networks (NN's). The statistical prediction property of such NN's is used in our work to develop a neural network based replacement policy which can effectively identify and eliminate inactive cache lines. This would provide larger free space for a cache to retain actively referenced lines. The proposed strategy may, therefore, yield better cache performance as compared to the conventional schemes. Simulation results for a wide spectrum of cache configurations indicate that the estimating neural network based replacement scheme provides significant performance advantage over existing policies.
Investigation of growth parameter influence on hydrothermally grown ZnO nanowires using a research grade microwave (2009)

Hydrothermal growth methods allow for low-temperature synthesis of ZnO nanowires (NWs) directly on a variety of novel substrates required for proposed flexible substrate applications such as power-harvesting fabrics. Although hydrothermal growth opens up a new realm of application possibilities, a major drawback of this method is growth time up to 20 hours or longer have been reported as necessary to yield desired NW morphologies. The use of microwave heating of the nutrient solution has recently been reported to speed the growth process. Although hydrothermal growth temperature has been reported to be a critical process variable, the conventional microwave used previously did not offer a direct method of controlling process temperature. Using a research grade microwave oven, equipped with integrated temperature control, the impact of growth temperature, growth time, and solution concentration on ZnO nanowire length, diameter, aspect ratio, growth orientation, density and wire morphology is investigated. Using a microwave with infrared temperature control, results demonstrate that ZnO NW growth time can be decreased significantly compared to traditional hydrothermal methods, that growth rate may be easier to control with temperature, rather than microwave power, and that by controlling the growth parameters that we can tailor NW morphology for a given application.
An Investigation of Some Hydroxamic Acids (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Investigation of Some Hydroxamic AcidsWarren M. Wise and Warren W. BrandtCite this: J. Am. Chem. Soc. 1955, 77, 4, 1058–1059Publication Date (Print):February 1, 1955Publication History Published online1 May 2002Published inissue 1 February 1955https://pubs.acs.org/doi/10.1021/ja01609a091https://doi.org/10.1021/ja01609a091research-articleACS PublicationsRequest reuse permissionsArticle Views422Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CORROSION EVALUATION OF CARBON STEELS USING NONDESTRUCTIVE TECHNIQUE (2008)

Primary water stress corrosion crack (PWSCC) in the piping used at the nuclear power plant has been one of the major issues for the safety of plant. The major objective in this paper is to clarify the corrosion degree and damage by the PWSCC using nondestructive technique. The instrument of the tube typed reactor with the internal conditions of the temperature of 473K under pressure of 10 MPa was designed for corrosion of the material. The tensile specimens of the same material with the reactor were corroded in the reactor for evaluation of mechanical properties according to the corrosion. The corrosion of the specimen was maintained over one year, and an acoustic emission technique was applied to inspect the corrosion damage of the specimen periodically. A tensile test was performed for the corroded specimen, and then the elastic waves caused the deformation of the corroded specimen were analyzed. With the increase of the corrosion time the elastic waves generated in the specimen due to the tensile load showed a little difference, and these differences of the waves work as a cause of the change of acoustic emission (AE) parameters. The number of AE events at the beginning of the load increased with the corrosion time. AE parameters of amplitude and energy decreased as the corrosion times increased, while the level of duration time and count were increased with the corrosion periods. The velocity and attenuation of the elastic wave were also analyzed for the specimen, and these factors showed a close relation with the corrosion times. In addition, SEM and XRD analysis were performed to evaluate the damage behavior of the carbon steel due to corrosion.
Coronary oxygen persufflation combined with HTK cardioplegia prolongs the preservation time in heart transplantation (2000)

These data show that COP combined with a mHTK solution represents a potential alternative to complement currently used cold storage techniques for prolonged preservation periods.
Extraction of threshold voltage degradation modeling due to Negative Bias Temperature Instability in circuits with I/O measurements (2014)

Negative Bias Temperature Instability (NBTI) is a serious reliability issue for pMOS transistors. Normally, degradation due to NBTI is modeled based on test structure data or ring oscillators embedded within product die. In this paper, we present a new method to determine the NBTI model parameters through I/O circuit measurements. We determine a relationship between Δ V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> and signature signal degradation and fit a model to the simulation results. The signature signal involves the calculation of the degradation in the voltage signature, measured as delay and amplitude shifts. Given an estimate of Δ V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> we find NBTI model parameters. Then, using the NBTI parameters at test conditions, we scale to use conditions and calculate lifetime. The methodology enables the extraction of NBTI model parameters for individual chips, not just for the manufacturing process, and hence it becomes possible to identify chips that are more vulnerable to NBTI.
Profiling of optical waveguide flames (1986)

Determination of the temperature field of flames produced on optical waveguide (OWG) burners is essential to the analysis of SiO2-GeO2 glass formation and deposition processes during OVD. Burner design modifications are reflected in the flame temperature profile and can be related to changes in the OVD deposition efficiency. Highly sensitive laser-based optical techniques can be used to obtain spatially and temporally resolved temperature measurements without perturbing the flame as has been observed when utilizing thermocouple probes. The measurement method which has been investigated at Corning Is thermally assisted fluorescence (THAF) spectroscopy.1 THAF has been used previously to probe premix flames and diffusion jets.2
Reactions of Perfluoroalkyl Nitriles. V. Synthesis of Perfluoroacyl Imidates<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Perfluoroalkyl Nitriles. V. Synthesis of Perfluoroacyl Imidates1Henry C. Brown and Charles R. WetzelCite this: J. Org. Chem. 1965, 30, 11, 3724–3728Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/jo01022a031https://doi.org/10.1021/jo01022a031research-articleACS PublicationsRequest reuse permissionsArticle Views276Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b (1994)

Heme can serve Haemophilus influenzae as a source of both essential porphyrin and iron. In extracellular mammalian body fluids neither free heme nor free iron is available, since they are tightly bound to hemopexin and transferrin, respectively. Since H. influenzae grows in the presence of iron-transferrin and heme-hemopexin and is known to express a saturable receptor for transferrin, we investigated the process by which this pathogen acquired heme from hemopexin for use as an iron source. The ability of human and rabbit hemopexin to donate heme as a source of iron to H. influenzae type b strains was demonstrated by plate bioassays. With a dot enzyme assay with biotinylated hemopexin as ligand, H. influenzae bound heme-hemopexin and apo-hemopexin following growth in iron-restricted, but not in iron-sufficient, medium. Competitive binding studies with heme-hemopexin and apo-hemopexin demonstrated saturability of binding. Neither heme, protoporphyrin IX, hemoglobin, nor transferrin blocked the binding of hemopexin to whole cells, demonstrating the specificity of binding. Treatment of whole H. influenzae cells with trypsin abolished binding. Taken together, these observations suggest that H. influenzae type b expresses an outer membrane protein(s) which acts as a receptor for hemopexin and which is regulated by the availability of iron in the growth medium. In iron-restricted media, H. influenzae 706705 and DL42 did not express the 100-kDa hemopexin-binding protein previously reported (M.S. Hanson, S.E. Pelzel, J. Latimer, U. Muller-Eberhard, and E.J. Hansen, Proc. Natl. Acad. Sci. USA 89:1973-1977, 1992). The putative iron-regulated hemopexin receptor was solubilized from cell envelopes of H. influenzae 706705, DL42, and Eagan with the detergent CHAPS (3-[(3-cholamidopropyl)-dimethyl-ammonio]-1-propanesulfonate) and isolated by affinity chromatography on heme-hemopexin-Sepharose 4B. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the proteins bound to the affinity resin revealed three proteins of 29, 38, and 57 kDa, of which the 57- and 29-kDa proteins bound hemopexin after Western blotting (immunoblotting). A monoclonal antibody to the 57-kDa hemopexin-binding protein of 706705 recognized a 57-kDa protein on Western blots of the cell envelope proteins of 706705, DL42, and Eagan; no reaction was observed with the 100-kDa hemopexin-binding protein of DL42. These data suggest that some H. influenzae strains possess at least two hemopexin receptors, the expression of which is determined by the prevailing growth environment.
ON AUTOMATIC FEATURE SELECTION (1988)

We review recent research on methods for selecting features for multidimensional pattern classification. These methods include nonmonotonicity-tolerant branch-and-bound search and beam search. We describe the potential benefits of Monte Carlo approaches such as simulated annealing and genetic algorithms. We compare these methods to facilitate the planning of future research on feature selection.
The monod equation: A revisit and a generalization to product inhibition situations (1980)

Abstract This paper shows how to treat the substrate‐limiting Monod equation in a straight forward manner for different types of fermentors (plug‐flow, batch, and mixed‐flow) using the general language of chemical reaction engineering. Straight‐line plots are developed for directly finding the kinetic constants of the equation, and an example using Monod's original data illustrates the procedure. The Monod equation is then generalized to account for the effects of both substrate and inhibitory toxic wastes. Finally, for pure product inhibition performance, expressions are derived for various reactor types, and correlation graphs are developed for finding the kinetic constants of the reaction. An example from the recent literature shows that this equation form fits the data extremely well.
Using Barrier Graphs for Deadlock Prevention in Communication Networks (1984)

Based on the theoretical framework given by Gunther [1], this paper provides a method which permits designing deadlock-free communication networks with a tradeoff between routing constraints and the number of resource classes. This tradeoff may be adapted for specific network requirements like availability, throughput, and cost. The graph-theoretical basis of this "barrier graph" approach allows easy implementation and has low execution time overhead.
Pathogen dynamics in a crop canopy and their evolution under changing climate (2011)

Canopy‐level interactions have been largely ignored in epidemiological models and their applications in defining disease risks under climate change, although these interactions are important for disease management. This paper uses anthracnose of Stylosanthes scabra as a case study and reviews research on dynamics of the pathogen ( Colletotrichum gloeosporioides ) at the canopy level and pathogen evolution under changing climate. It argues that linking of pathogen dynamics, crop growth and climate models is essential in predicting disease risks under climate change. A plant functional‐structural model was used to couple S. scabra growth and architecture with disease under ambient and elevated CO 2 . A level of induced resistance in plants with enlarged canopy determined anthracnose severity at elevated CO 2 . Moisture‐related microclimatic variables determined infection at ambient but not at elevated CO 2 . At high CO 2 increased disease level from raised pathogen fecundity in enlarged canopy accelerated pathogen evolution after 25 sequential infection cycles. Modelling of pathogen dynamics under climate change currently suffers from a paucity of quantitative data, mismatch of scales in coupling climate and disease models, and model uncertainties. Further experimental research on interactions of biotic and abiotic factors on plant diseases under climate change and validation of models are essential prior to their use in climate‐change prediction. Understanding and anticipating trends in host–pathogen evolution under climate change will improve the durability of resistance and lay the foundation for increased crop adaptation through pre‐emptive plant breeding.
The chemical synthesis of deoxyribo‐oligonucleotides complementary to a portion of the lysozyme gene of phage T4 and their hybridization to phage specific RNA and phage DNA (1973)

We are app,Ioact~g the probtem of isolating ~echqc mRNA* molecules by ~he use of a synthetic deoxyfibo-ol~gonueleo~ide, complementary .
Linear discriminant analysis: A detailed tutorial (2017)

Linear Discriminant Analysis (LDA) is a very common technique for dimensionality reduction problems as a pre-processing step for machine learning and pattern classification applications. At the same time, it is usually used as a black box, but (sometimes) not well understood. The aim of this paper is to build a solid intuition for what is LDA, and how LDA works, thus enabling readers of all levels be able to get a better understanding of the LDA and to know how to apply this technique in different applications. The paper first gave the basic definitions and steps of how LDA technique works supported with visual explanations of these steps. Moreover, the two methods of computing the LDA space, i.e. class-dependent and class-independent methods, were explained in details. Then, in a step-by-step approach, two numerical examples are demonstrated to show how the LDA space can be calculated in case of the class-dependent and class-independent methods. Furthermore, two of the most common LDA problems (i.e. Small Sample Size (SSS) and non-linearity problems) were highlighted and illustrated, and state-of-the-art solutions to these problems were investigated and explained. Finally, a number of experiments was conducted with different datasets to (1) investigate the effect of the eigenvectors that used in the LDA space on the robustness of the extracted feature for the classification accuracy, and (2) to show when the SSS problem occurs and how it can be addressed.
New Measurement Method of Polar Anchoring Energy of Nematic Liquid Crystals (2000)

Abstract On the basis of the concept used in the high-electric-field method reported by Yokoyama, we have developed a new measurement method of the polar anchoring energy of nematic liquid crystals. This method can derive the polar anchoring energy only by measuring the capacitance change against the applied voltage of a LC sample, and thus the method can be easily applied to measuring the polar anchoring energy of homeotropically-aligned samples. This paper presents the results of the computer simulation for verifying the developed method and also some experimental results of the polar anchoring energy for homeotropically-aligned samples.