gebhart/patrepeval huggingface dataset:
Subunit Antigen and Activity Levels of Blood Coagulation Factor XIII in Healthy Individuals (1999)

Factor (F) XIII covalently cross-links and stabilizes the fibrin-clot. Recent evidence suggests a role for FXIII in atherothrombotic diseases, but no information is available regarding the association of FXIII with common risk factors. The aim of this study was to investigate the relationship of FXIII with age, sex, smoking, and hypertension. Plasma levels of FXIII A-subunit antigen, FXIII B-subunit antigen, and FXIII cross-linking activity were measured in 612 healthy individuals (250 men and 362 women). FXIII A- and B-subunit levels were correlated significantly with age in both men (r=0.21, P=0.001, and r=0.17, P=0.008, respectively) and women (r=0.20, P<0.0005, and r=0.13, P=0.011, respectively). FXIII B-subunit levels and activity were correlated significantly with FXIII A-subunit levels (r=0.60, P<0.0005, and r=0.14, P<0.0005, respectively) and fibrinogen (r=0.26, P<0.0005, and r=0.14, P=0.001, respectively). Women had higher levels of FXIII A-subunit (111.8% versus 105.2%, P<0.01) and B-subunit (109.5% versus 103.8%, P<0.01) than did men. FXIII A-subunit was significantly increased in smokers (117.0% versus 104.6%, P<0.0005) and in subjects with hypertension (114.9% versus 107.8%, P<0.05). In a multiple regression model, FXIII A-subunit was significantly increased by female sex (+6.4%, P<0.007), smoking (+12.3%, P<0.0005), and increasing age (+3.7% per 10 years, P<0.0005). FXIII B-subunit was significantly related to female sex and fibrinogen, and FXIII activity was significantly related to fibrinogen levels. In conclusion, the FXIII A-subunit level increases significantly with female sex, age, and smoking, whereas FXIII B-subunit and FXIII activity are associated with FXIII A-subunit level and fibrinogen. Although evidence for a causal relationship between FXIII A-subunit and vascular disease is not available, these results might suggest a role for elevated FXIII A-subunit levels in the pathogenesis of vascular disease.
Peripheral nerve stimulation suppression of C-fiber-evoked flexion reflex in rats (1985)

Transcutaneous electrical nerve stimulation (TENS) is now a well established clinical technique to alleviate chronic pain. Its mechanism of action remains unknown and the stimulation parameters used are based on subjective reports from patients. In the present study, a systematic investigation has been performed with conditioning stimulation of different parameters delivered to a dissected skin nerve in the lightly anesthetized rat, utilizing the size of a C-fiber-evoked flexion reflex as a measure of transmission from nociceptive afferent fibers in the spinal cord. A stimulation intensity that recruited both A-beta and A-delta fibers was more effective in depressing the C-fiber-evoked reflex at all frequencies studied than were intensities activating A-beta fibers only. A stimulation frequency of 80 Hz gave the most profound inhibition. The implications for clinical treatment are discussed.
Application of Enzyme in Extraction of Traditional Chinese Medicine (2011)

The enzymatic mechanism and application in the extraction and separation of traditiomal chinese medicine was reuiewed.Cellulase,pectolase,papayin,and so on can destroy the plant cell wall,so effective component is easy to leach out.The enzyme obtained the widespread application in the Chinese native medicine extraction.The application of enzyme method in the extraction of Polysaccharide,Flavonoids,oil,Alkaloids,Saponins,and the application of biological enzyme technology in the purification of plant extracts of the traditional Chinese medicine were descrilzed.Combined with new technology,enzyme method is used in the extraction of traditional Chinese medicine.The existing problems of enzyme was analysed,outlooking the prospects of enzyme in the extraction of traditional chinese medicine.
[Ultrastructural and functional changes of rabbit myocardium after cholesterol feeding]. (1978)

The myocardium was ultrastructurally investigated immediately after 12 weeks of feeding in one part of the animals and in the remaining animals 27--30 months after termination of the feeding period. At the same time, parameters of the myocardial contraction were measured immediately after the feeding at isolated trabeculae of the left ventricle and 27--30 months after the termination of the feeding at the left ventricle in situ. After the 12 weeks of feeding the morphometrically estimated intracellular lipid content rises from 0.23% (normal) to 5.26%. The mitochondria decline from 36.98% (normal) to 29.08%. The sarcoplasmic reticulum (SR) changes in a vesicular or vacuolar manner respectively. The contractility index Vmax of isolated trabeculae decreases insignificantly. The resting potentiation and the diastolic stiffness are increased. 27--30 months after termination of feeding the lipid content and the mitochondria are normal in comparison to controls of the same age. The vacuolar changes of SR and its cellular portion are increased. The contractility index of the heart in situ max (dp/dt)/P is decreased insignificantly. The velocity of relaxation is enhanced in comparison with controls. By comparing ultrastructural and functional findings it can be seen that variations in the contraction performance are accompanied by stronger changes of the cellular structure immediately after the feeding than 27--30 months after the termination of the feeding. At this time continuing small alterations in the contraction performance of the heart in situ are observed in addition to the reversibility of various characteristics of damage together with an increase in the Ca++-transporting SR and its alterations.
The Host Range of Downy Mildew, Peronospora parasitica, from Brassica oleracea, Cabbage and Broccoli Crops. (1996)

We collected three cabbage plants infected with Peronospora parasitica in Kagawa, two broccoli plants in Mie and one broccoli plant in Tottori. Five single spore isolates from each sample were prepared, and the host range of thirty single spore isolates in total was examined. Test plants used for the host range tests were Brassica oleracea (eighteen cultivars of cauliflower, cabbage and broccoli), B. campestris (eight cultivars of Pak-choi, mizuna, rape, Chinese cabbage and turnip), B. juncea (one cultivar of leaf mustard), B. napus (one cultivar of rutabaga) and Raphanus sativus (two cultivars of Japanese radish). In all the test plants, cotyledons with hypocotyl were used for the inoculation tests. All the B. oleracea plants except two cultivars of cabbage were highly susceptible to all the tested isolates, and it is considered that this is a host species of the fungus. B. napus was moderately susceptible, and suggested to be a possible host species. B. campestris, B. juncea and R. sativus were resistant, and considered to be non-host species. Therefore, all the isolates were considered to belong to the same strain of the fungus and the strain to be specific to B. oleracea and possibly to B. napus. Among B. oleracea plants, two cultivars of cabbage cv. Golden Best and cv. YR-Sawamidori were resistant. Difference in pathogenicity was not found among the tested single spore isolates.
Multi-grain coherence directories (2013)

Conventional directory coherence operates at the finest granularity possible, that of a cache block. While simple, this organization fails to exploit frequent application behavior: at any given point in time, large, continuous chunks of memory are often accessed only by a single core.
Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis (2015)

Stimulator of interferon genes (STING) has been shown to be critical for controlling antiviral responses as well as anti-tumor adaptive immunity, but little is known regarding its regulation in human tumors. Here, we report that STING signaling is recurrently suppressed in a wide variety of cancers, including colorectal carcinoma. Loss of STING signaling impeded DNA damage responses accountable for generating key cytokines that facilitate tissue repair and anti-tumor T cell priming, such as type I interferons (IFNs). Correspondingly, defective STING function was also highly predictive of effectual DNA-virus-mediated oncolytic activity. Thus, impaired STING responses may enable damaged cells to evade host immunosurveillance processes, although they provide a critical prognostic measurement that could help predict the outcome of effective oncoviral therapy.
155. The cross-linking of vinyl polymers by Friedel–Crafts catalysts. Part I (1948)

J. C. Bevington and R. G. W. Norrish, J. Chem. Soc., 1948, 771 DOI: 10.1039/JR9480000771
Maximum likelihood mapping with spectral image registration (2010)

A core challenge in probabilistic mapping is to extract meaningful uncertainty information from data registration methods. While this has been investigated in ICP-based scan matching methods, other registration methods have not been analyzed. In this paper, an uncertainty analysis of a Fourier Mellin based image registration algorithm is introduced, which to our knowledge is the first of its kind involving spectral registration. A covariance matrix is extracted from the result of a Phase-Only Matched Filter, which is interpreted as a probability mass function. The method is embedded in a pose graph implementation for Simultaneous Localization and Mapping (SLAM) and validated with experiments in the underwater domain.
Automatic Feature Learning for Robust Shadow Detection (2014)

We present a practical framework to automatically detect shadows in real world scenes from a single photograph. Previous works on shadow detection put a lot of effort in designing shadow variant and invariant hand-crafted features. In contrast, our framework automatically learns the most relevant features in a supervised manner using multiple convolutional deep neural networks (ConvNets). The 7-layer network architecture of each ConvNet consists of alternating convolution and sub-sampling layers. The proposed framework learns features at the super-pixel level and along the object boundaries. In both cases, features are extracted using a context aware window centered at interest points. The predicted posteriors based on the learned features are fed to a conditional random field model to generate smooth shadow contours. Our proposed framework consistently performed better than the state-of-the-art on all major shadow databases collected under a variety of conditions.
Fabrication of curved mirrors for visible semiconductor lasers using electron-beam lithography and chemically assisted ion-beam etching (1993)

(Al)GaInP ridge-waveguide lasers with curved dry-etched mirrors have been fabricated which operate in the visible-light regime at a wavelength of 690 nm. High-resolution electron-beam lithography is used to define the mirror shapes in a 25 nm design grid while the rest of the fabrication technology is done conventionally by optical lithography. The mirror patterns are transferred into the underlying epitaxial layers by chemically assisted ion-beam etching. The properties of the laser devices are comparable to devices with cleaved facets. Single-mode behavior is observed up to cw output power levels of 30 mW. The horizontal far-field angle of the emitted light can be influenced by varying the curvature radius of the mirror facets.
Evaluation of renal function from 99mTc-MAG3 renography without blood sampling. (1999)

99mTc-MAG3 clearance can be assessed with acceptable accuracy by a camera-based method. The method based on the slope of the renogram may replace the one based on the area under the renogram in evaluating renal function from 99mTc-MAG3 renograms.
Fast atom beam-activated n-Si/n-GaAs wafer bonding with high interfacial transparency and electrical conductivity (2013)

Optically transparent, electrically conductive n-Si/n-GaAs direct wafer bonds are achieved by a thorough optimization of surface conditioning using fast atom beams. Bonding at room temperature under high-vacuum conditions is systematically investigated after in situ surface deoxidization using either argon or helium fast atom beams. Using argon, high bond energies of up to 900 mJ/m2 are obtained and further enhanced to achieve bulk strength through rapid annealing at 290 °C, thereby enabling the production of thermally stable and mechanically robust hybrid substrates. Moreover, the interface conductivity is significantly improved by an additional thermal annealing at 400 °C. Although it is anticipated to induce higher quality interfaces, helium treatment yields, however, limited and unstable bonding. This difference is attributed to an important surface nano-texturing that occurs during fast atom beam processing, a phenomenon that is peculiar to helium and absent in argon treatment.
Underwater 3D imaging by FFT dynamic focusing beamforming (2002)

Describes an application of the dynamic focusing technique for underwater 3D acoustic imaging. In particular, the integration of dynamic focalization with an FFT implementation of phase-shift beamforming has been developed in order to avoid an increase in computational complexity. The resulting system, which uses narrow-band signals, permits the formation of 3D images at a high frame rate and without the limitations imposed by the depth of field on fixed-focused beamforming. Some simulations made it possible to test the proposed system, and the related results are reported.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
University of Colorado dialog systems for travel and navigation (2001)

This paper presents recent improvements in the development of the University of Colorado "CU Communicator" and "CU-Move" spoken dialog systems. First, we describe the CU Communicator system that integrates speech recognition, synthesis and natural language understanding technologies using the DARPA Hub Architecture. Users are able to converse with an automated travel agent over the phone to retrieve up-to-date travel information such as flight schedules, pricing, along with hotel and rental car availability. The CU Communicator has been under development since April of 1999 and represents our test-bed system for developing robust human-computer interactions where reusability and dialogue system portability serve as two main goals of our work. Next, we describe our more recent work on the CU Move dialog system for in-vehicle route planning and guidance. This work is in joint collaboration with HRL and is sponsored as part of the DARPA Communicator program. Specifically, we will provide an overview of the task, describe the data collection environment for in-vehicle systems development, and describe our initial dialog system constructed for route planning.
Differential regulation of macrophage differentiation in response to leukemia inhibitory factor/oncostatin-M/interleukin-6: the effect of enforced expression of the SCL transcription factor (1995)

The physiologic program of macrophage differentiation normally proceeds in a coordinated manner in response to several different growth factors. Although the utilization of common receptor subunits may explain in part overlapping biologic functions, mechanisms by which unique actions are mediated remain obscure. We examined growth factor- induced macrophage differentiation in M1 leukemia cells that simultaneously display receptors for interleukin-6 (IL-6), leukemia inhibitory factor (LIF) and Oncostatin-M (OSM). Differentiation induced by all three factors was associated with decreased expression of transcription factors myb and SCL, increased expression of macrophage markers, and suppression of proliferation. Cell lines were established in which SCL expression was enforced. In the absence of growth factors, cells were indistinguishable from parental cells. However, LIF (or OSM)- induced macrophage differentiation was perturbed; there was failure to undergo morphologic differentiation, disturbed expression of lysozyme and Mac1 alpha, and failure to suppress proliferation. Surprisingly the perturbation of macrophage differentiation did not apply to induced expression of macrophage colony-stimulating factor (M-CSF) or granulocyte colony stimulating factor (G-CSF) receptors. This dissociation of elements normally coordinated in a macrophage differentiation program applied at a clonal level. There was no disturbance of IL-6-induced macrophage differentiation. These data directly implicate SCL in components of the macrophage differentiation program (suggesting that LIF receptor/gp130 heterodimers utilize an SCL- inhibitable pathway while gp130 homodimers do not) and demonstrate differential-regulation of components of the mature macrophage phenotype.
HERIS: Integrated Information Search in the WWW and a User Group (2002)

In this paper, we propose a framework for searching information through both the WWW and a human group. Though information retrieval using a searc engine in the WWW is very useful, we can not acquire local information owned by persons and not explicitly described in text. A user knows neither where target information is in the WWW nor who knows in a human group. Thus we integrate the information retrieval in the WWW with that in a human group, develop a heterogeneous information search system HERIS as a multi-agent system. We develop this framework as multi-agent system consisting of user agents and search engine agents, and use contract net protocol to communication among the agents. A user agent and a search engine agent are assigned to a user and a search engine. Each of the agents maintains a user profile and a search engine profile. When a user gives a query to a system, it selectively searches information resources consisting the WWW and user group. Finally a user acquires integrated results of a hit list from the WWW and a audio/video connection to a user who can answer the query. It was found through experimental evaluation that information retrieval using a human group as an information resource is valid and a search with HERIS has a different character from conventional search engines.
Methylsilicones--Their Chemistry and Use as Gas Chromatographic Liquid Phases (1973)

Journal Article Methylsilicones—Their Chemistry and Use as Gas Chromatographic Liquid Phases Get access Charles R. Trash Charles R. Trash Ohio Valley Specialty Chemical, Inc., Route 1, Brant Drive, Marietta, Ohio 45750 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 11, Issue 4, April 1973, Pages 196–198, https://doi.org/10.1093/chromsci/11.4.196 Published: 01 April 1973 Article history Received: 09 January 1973 Published: 01 April 1973
X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart (2011)

We report that in heart cells, physiologic stretch rapidly activates reduced-form nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling). ROS production occurs in the sarcolemmal and t-tubule membranes where NOX2 is located and sensitizes nearby ryanodine receptors (RyRs) in the sarcoplasmic reticulum (SR). This triggers a burst of Ca(2+) sparks, the elementary Ca(2+) release events in heart. Although this stretch-dependent "tuning" of RyRs increases Ca(2+) signaling sensitivity in healthy cardiomyocytes, in disease it enables Ca(2+) sparks to trigger arrhythmogenic Ca(2+) waves. In the mouse model of Duchenne muscular dystrophy, hyperactive X-ROS signaling contributes to cardiomyopathy through aberrant Ca(2+) release from the SR. X-ROS signaling thus provides a mechanistic explanation for the mechanotransduction of Ca(2+) release in the heart and offers fresh therapeutic possibilities.
Poloxamer Hydrogels for Biomedical Applications (2019)

This review article focuses on thermoresponsive hydrogels consisting of poloxamers which are of high interest for biomedical application especially in drug delivery for ophthalmic, injectable, transdermal, and vaginal administration. These hydrogels remain fluid at room temperature but become more viscous gel once they are exposed to body temperature. In this way, the gelling system remains at the topical level for a long time and the drug release is controlled and prolonged. Poloxamers are synthetic triblock copolymers of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO), also commercially known as Pluronics<sup>®</sup>, Synperonics<sup>®</sup> or Lutrol<sup>®</sup>. The different poloxamers cover a range of liquids, pastes, and solids, with molecular weights and ethylene oxide-propylene oxide weight ratios varying from 1100 to 14,000 and 1:9 to 8:2, respectively. Concentrated aqueous solutions of poloxamers form thermoreversible gels. In recent years this type of gel has arouse interest for tissue engineering. Finally, the use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC). This property is exploited for drug delivery and different therapeutic applications.
Analytical solution to the Curtin-Hammett/Winstein-Holness kinetic system (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalytical solution to the Curtin-Hammett/Winstein-Holness kinetic systemJeffrey I. Seeman and William A. FaroneCite this: J. Org. Chem. 1978, 43, 10, 1854–1864Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://pubs.acs.org/doi/10.1021/jo00404a002https://doi.org/10.1021/jo00404a002research-articleACS PublicationsRequest reuse permissionsArticle Views349Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Limit to the Deesterification of Citrus Pectin by Citrus Pectinesterase (1987)

Journal Article Limit to the Deesterification of Citrus Pectin by Citrus Pectinesterase Get access Yasushi Matsuura Yasushi Matsuura Department of Food Science, Okayama Prefectural Junior College, Ishima-cho, Okayama 700, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 51, Issue 6, 1 June 1987, Pages 1675–1677, https://doi.org/10.1080/00021369.1987.10868248 Published: 01 June 1987 Article history Received: 11 August 1986 Published: 01 June 1987
Optimization and Machine Learning Methods for Medical and Healthcare Applications (2016)

Thesis (Ph.D.)--University of Washington, 2016-12