gebhart/patrepeval huggingface dataset:
Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors (1992)

The chromosome 22 breakpoint of the t(11;22) translocation of peripheral neuroepithelioma has been located, by fluorescence in situ hybridization, in the proximity of the interface between 22q12.1 and 22q12.2. Use of single cosmids or pools of cosmids of the flanking regions enables the monitoring of the translocation in interphase and in metaphase chromosomes. This method can now be routinely applied for the diagnosis of this translocation in mixed round cell tumors.
ChemInform Abstract: THE REACTION OF 4‐ALKYL‐3‐THIOSEMICARBAZIDES WITH β‐HALO KETONES (1984)

Abstract Die β‐Chlorpropiophenone (I) reagieren mit Thiosemicarbaziden (II) zu Pyrazolincarbothioamiden (III).
The Success or Failure of the Hair Transplant (1973)

The hair transplant operation is a reliable procedure which will give good results if attention is directed to each step of the process. Unfortunately, the results are often not good, and many patients have suffered severe emotional and physical scars. Because it appears to be a simple office procedure, many physicians with various backgrounds have been tempted to try it, apparently with little thought or preparation. Some of the poor results gathered from all parts of the country and from many types of medical practice are presented. If the procedure is not to fall into disrepute, the surgeon must be more attentive to aesthetic and surgical principles.
Aquaculture: farming aquatic animals and plants. 3rd edition (2019)

This new edition of Aquaculture: Farming Aquatic Animals and Plants covers important aspects of the culture of fish, shellfish, and algae in freshwater and marine environments. Subject areas covered include principles of aquaculture, water quality, environmental impacts of aquaculture, desert aquaculture, reproduction, life cycles and growth, genetics and stock improvement, nutrition and feed production, diseases, vaccination, post-harvest technology, economics and marketing, and future developments of aquaculture. Separate chapters also cover the culture of algae, carps, salmonids, tilapias, catfish, marine and brackish fishes, soft-shelled turtles, barramundi, marine shrimp, mitten crabs, and other decapod crustaceans, bivalves, gastropods, and ornamental species. This edition also provides greater coverage of aquaculture in China, reflecting the country’s importance in the global scene. Providing core scientific and commercially useful information, and written by 35 eminent international authors, this expanded and fully updated Third Edition of Aquaculture is essential reading for all students and professionals studying and working in aquaculture. Fish farmers, hatchery managers, and those in aquaculture support and supply industries, such as feed manufacturing, will find an abundance of commercially useful information within this important and now established book.
Results of long‐term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators (1995)

This report updates the combined experience of four centres involved in the long-term treatment of transfusional iron overload in 84 patients with the oral iron chelator deferiprone (L1) over 167 patient-years. The source of L1 was variable, including two university research laboratories and three pharmaceutical firms. Compliance was rated as excellent in 48%, intermediate in 36%, and poor in 16% of patients. On a mean L1 dose of 73-81 mg/kg/d, urinary iron excretion was stable, at around 0.5 mg/kg/d, with no indication of a diminishing response with time. Serum ferritin showed a very steady decrease with time from an initial mean +/- 1 SD of 4207 +/- 3118 to 1779 +/- 1154 micrograms/l after 48 months (P < 0.001). 17 patients abandoned L1 therapy. Major complications of L1 requiring permanent discontinuation of treatment included agranulocytosis (three), severe nausea (four), arthritis (two) and persistent liver dysfunction (one). The remaining patients abandoned treatment because of low compliance (three) and conditions unrelated to L1 toxicity (four). Lesser complications permitting continued L1 treatment included transient mild neutropenia (four), zinc deficiency (12), transient increase in liver enzymes (37), moderate nausea (three) and arthropathy (17). There was no treatment-related mortality. Although the complications associated with L1 treatment are significant and require close monitoring, they do not preclude effective long-term therapy in the vast majority of patients. Further well-controlled prospective studies of L1 are required in order to enable proper judgement of its suitability for general long-term clinical use.
Cauliflower mosaic virus: Pathways of infection (1985)

Abstract This short review summarizes what is known, and points out some of the unknown features, about the molecular biology of the natural spread of cauliflower mosaic virus into a susceptible host and its subsequent replication in that host.
Comparison of temperature processing methods for monitoring focused ultrasound ablation in the brain (2013)

Hybrid multibaseline/referenceless thermometry accurately measures temperature changes in the brain with fewer artifacts and errors due to motion than pure baseline subtraction methods.
Deposition and analysis of carbon and silicon clusters generated by laser-induced gas phase reaction (1996)

Laser driven gas-phase synthesis in a flow reactor was employed for the production of carbon and silicon cluster beams starting from gaseous compounds. It is based on a CO2-laser-induced decomposition of molecular gases containing carbon and silicon, such as C2H2 and SiH4. By introducing a skimmer into the reaction zone, the generated clusters are transferred to the free molecular flow and analyzed with a time-of-flight mass spectrometer. These clusters were deposited on a silicon or saphire target at room temperature. Micro-Raman spectroscopy techniques was used for- characterization of this deposits. The present studies show that the laser-driven nucleation in a flow reactor is a powerful technique to produce fullerenes and silicon quantum dots and other nano-size semiconductors or high-temperature evaporated materials.
Focusing of spherical Gaussian beams (1983)

Simple procedures and formulas for tracing the characteristics of a spherical Gaussian beam through a train of lenses or mirrors are described which are analogous to those used in geometrical optics to trace repeated images through an optical train.
Safety, Efficacy, and Functionality of High-field Strength Interventional Magnetic Resonance Imaging for Neurosurgery (2000)

High-field (1.5-T) interventional MRI is a safe and effective technology for assisting neurosurgeons in achieving the goals of surgery. Preliminary results suggest that the functional capabilities of this technology can yield data that can significantly influence intraoperative neurosurgical decision-making. The rates of serious complications, such as infection, associated with this new technology were low.
Comparison of the Vasoconstrictive and Anesthetic Effects of Intranasally Applied Cocaine vs. Xylometazoline/Lidocaine Solution (1992)

Cocaine solution has traditionally been the agent of choice for vasoconstriction and anesthesia when applied topically to the nasal mucosa during nasal operative procedures. Because of the relative scarcity and resulting expense of cocaine, there has arisen an impetus for an alternative intranasal solution for mucosal anesthesia and vasoconstriction. As a logical alternative, we have used a mixed solution of xylometazoline and lidocaine with reasonable results. No clinical studies comparing the efficacy of the two solutions exist, however, and there is presently no such solution commercially available. A double-blind, randomized, placebo-controlled study was undertaken to assess the relative efficacy of the preparations. Both solutions resulted in a marked and roughly equivalent degree of mucosal vasoconstriction (as evidenced by comparable increases in nasal airway cross-sectional area). Subjective pain ratings of mucosal pin-prick decreased a surprisingly small degree after application of both solutions. It appears that xylometazoline/lidocaine solution is comparable to cocaine solution for purposes of vasoconstriction and anesthesia during intranasal operative procedures.
Seismic-While-Drilling in Kuwait Results and Applications (1996)

ABSTRACT During early 1994, Kuwait Oil Company and Schlumberger completed an extensive study of the Seismic-While-Drilling technique in two development wells in the Raudhatain field of North Kuwait. Seismic-While-Drilling records the energy radiated from a working drillbit (utilized as a seismic source), with receivers placed at the surface. This technology provides well seismic information such as checkshot and look ahead Vertical Seismic Profiling services at the wellsite, in real-time. The technique does not interfere with the drilling process nor does it require deploying any downhole hardware. The result of the study is that the Seismic-While-Drilling technique can work successfully in the Raudhatain field.
Substituted Styrenes. III. The Syntheses and Some Chemical Properties of the Vinylphenols<sup>1,2</sup> (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted Styrenes. III. The Syntheses and Some Chemical Properties of the Vinylphenols1,2Wesley J. Dale and Henry E. HennisCite this: J. Am. Chem. Soc. 1958, 80, 14, 3645–3649Publication Date (Print):July 1, 1958Publication History Published online1 May 2002Published inissue 1 July 1958https://pubs.acs.org/doi/10.1021/ja01547a044https://doi.org/10.1021/ja01547a044research-articleACS PublicationsRequest reuse permissionsArticle Views388Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence (2007)

Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments. The replicative lifespan of primary human cells is telomere dependent; however, its heterogeneity is not understood. We show that mitochondrial superoxide production increases with replicative age in human fibroblasts despite an adaptive UCP-2-dependent mitochondrial uncoupling. This mitochondrial dysfunction is accompanied by compromised [Ca(2+)]i homeostasis and other indicators of a retrograde response in senescent cells. Replicative senescence of human fibroblasts is delayed by mild mitochondrial uncoupling. Uncoupling reduces mitochondrial superoxide generation, slows down telomere shortening, and delays formation of telomeric gamma-H2A.X foci. This indicates mitochondrial production of reactive oxygen species (ROS) as one of the causes of replicative senescence. By sorting early senescent (SES) cells from young proliferating fibroblast cultures, we show that SES cells have higher ROS levels, dysfunctional mitochondria, shorter telomeres, and telomeric gamma-H2A.X foci. We propose that mitochondrial ROS is a major determinant of telomere-dependent senescence at the single-cell level that is responsible for cell-to-cell variation in replicative lifespan.
A Plague on Host Defense (2002)

“ … the plague bacillus never dies or disappears for good; … it bides its time in bedrooms, cellars, trunks, and bookshelves; and perhaps the day would come when, for the bane and the enlightening of men, it would rouse up its rats again and send them forth to die in a happy city.” Albert
Novel free-space optical interconnection architecture employing array devices (1991)

A novel architecture for free-space optical interconnections is proposed. The architecture named LISA (lightwave interconnections employing spatial addressing) enables the construction of a high speed and large fanout 1 × N switch. A 1 × 16 LISA switch is implemented and demonstrated at 200 Mbit/s.
Short‐ and long‐term stability studies on four lyophilised and one cell‐associated turkey herpesvirus vaccines against marek's disease of chickens<sup>1</sup> (1980)

One cell-associated and four lyophilised turkey herpesvirus (HVT) vaccines of different manufacturers were investigated comparatively in respect of the stability of their infectivity. All titrations were performed in primary chicken embryo fibroblast cell cultures and repeated seven times. The obtained data were computerised and statistically analysed. The long term stability study employed vaccine ampoules containing only lyophilised HVT. After appropriate storage in a refrigerator (4 degrees C) of all tested vaccine ampoules for 1 year no drop of titre was found. In contrast, storage at room temperature (24 degrees C) resulted in a loss of about 50% of the infectious units of HVT by 4 months. Marked differences between the products of different manufacturers were noted after 4 weeks of storage at 37 degrees or 45 degrees C. The infectivity dropped to values between 1/10 to 1/100 and 1/100 to 1/300, respectively. In the short term stability study cell-associated and lyophilised vaccine virus was resuspended in the manufacturer's diluent and maintained at temperatures of 4 degrees , 24 degrees , 37 degrees and 45 degrees C. The infectious units were titrated at 0, 2, 4, 6, 8 and 24 hours for estimation of the half life of the infectivity of HVT. The half life of infectivity of HVT at 4 degrees C was for three vaccines approximately 5 hours and for two vaccines between 1 and 3 hours. With increase of temperature the loss of infectivity increased resulting in half life times close to 1 hour at 45 degrees C.
Synthesis and Characterization of Biodegradable HPMA-Oligolysine Copolymers for Improved Gene Delivery (2009)

Bioactive peptides, including DNA-binding, endosomal release, and cell targeting peptides, have been integrated into synthetic gene carriers to improve delivery efficiency by enabling the vectors to overcome barriers to gene delivery. Our overall goal is to develop multifunctional, peptide-based polymers that incorporate motifs to condense DNA and facilitate sequential trafficking steps. One approach is to polymerize vinyl-terminated peptides by radical polymerization. In this work, cationic oligolysine peptides were designed to contain vinyl termini with internal reducible linkers. These peptides were copolymerized with HPMA to form biodegradable, DNA-condensing copolymers for gene delivery. The polymerization conditions were optimized by varying the initiator to monomer ratios, macromonomer to comonomer ratios, and reactant concentrations. The synthesized copolymers were shown to possess several important properties required for in vivo gene delivery applications, including (i) efficient DNA binding and condensation, (ii) the ability to stabilize particles against salt-induced aggregation, (iii) the ability to resist extracellular polyplex unpackaging, (iv) biocompatibility and the potential to be degraded into nontoxic components after cellular uptake, and (v) efficient delivery of plasmid to cultured cells.
Line fault prediction and location in echo cancelling data transmission systems (1984)

Theoretical and practical results are presented which show that the tap coefficients of an echo cancelling modem can be used as an aid to line fault prediction and location. It is indicated that in some cases it is possible to identify a line fault before the transmission performance is seriously impaired.
Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis (2008)

The interplay between demyelination and remyelination is critical in the progress of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). In the present study, we explored the capacity of glatiramer acetate (GA, Copaxone) to affect the demyelination process and/or lead to remyelination in mice inflicted by chronic EAE, using both scanning electron microscopy and immunohistological methods. Spinal cords of untreated EAE mice revealed substantial demyelination accompanied by tissue destruction and axonal loss. In contrast, in spinal cords of GA-treated mice, in which treatment started concomitantly with disease induction (prevention), no pathology was observed. Moreover, when treatment was initiated after the appearance of clinical symptoms (suppression) or even in the chronic disease phase (delayed suppression) when substantial demyelination was already manifested, it resulted in a significant decrease in the pathological damage. Detection of oligodendrocyte progenitor cells (OPCs) expressing the NG2 or O4 markers via colocalization with the proliferation marker BrdU indicated their elevated levels in spinal cords of GA-treated mice. The mode of action of GA in this system is attributed to increased proliferation, differentiation, and survival of OPCs along the oligodendroglial maturation cascade and their recruitment into injury sites, thus enhancing repair processes in situ.
Apolipoprotein E Isoforms Increase Intracellular Ca<sup>2+</sup> Differentially Through a ω‐Agatoxin IVa‐Sensitive Ca<sup>2+</sup>‐Channel (1998)

Apolipoprotein E (apoE) is the major apolipoprotein in the brain and is known for its important role in plasticity and neurodegeneration. We show that apoE dose-dependently increases intracellular free Ca2+ in rat hippocampal astrocytes and neurons. This effect varies with isoforms in the order E4 > E3 > E2. It is insensitive to blockade of action potentials by tetrodotoxin or inhibition of binding of apoE by heparinase, by the LRP ligand lactoferrin and by low density lipoprotein. ApoE evoked Ca2+-increases are blocked in zero [Ca]o and by the Ca-channel antagonists nickel and omega-Agatoxin-IVa but not by nifedipine and omega-Conotoxin-GVIa, demonstrating an isoform-specific activation of P/Q type Ca2+-channels. This novel mechanism is discussed with respect to Alzheimer's disease, that is linked for most cases to the apoE epsilon-allelic variation (epsilon4 > epsilon3 > epsilon2).
Emotions in context: examining pervasive affective sensing systems, applications, and analyses (2015)

Abstract Pervasive sensing has opened up new opportunities for measuring our feelings and understanding our behavior by monitoring our affective states while mobile. This review paper surveys pervasive affect sensing by examining and considering three major elements of affective pervasive systems, namely “sensing,” “analysis,” and “application.” Sensing investigates the different sensing modalities that are used in existing real-time affective applications, analysis explores different approaches to emotion recognition and visualization based on different types of collected data, and application investigates different leading areas of affective applications. For each of the three aspects, the paper includes an extensive survey of the literature and finally outlines some of challenges and future research opportunities of affective sensing in the context of pervasive computing.
The Effect of Ultraviolet Irradiation on Immune Serum (1953)

Journal Article The Effect of Ultraviolet Irradiation on Immune Serum Get access J. R. Battisto, J. R. Battisto From the Department of Bacteriology, University of Michigan Medical School, Ann Arbor, Michigan Search for other works by this author on: Oxford Academic PubMed Google Scholar R. B. Pringle, R. B. Pringle From the Department of Bacteriology, University of Michigan Medical School, Ann Arbor, Michigan Search for other works by this author on: Oxford Academic PubMed Google Scholar W. J. Nungester W. J. Nungester From the Department of Bacteriology, University of Michigan Medical School, Ann Arbor, Michigan Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 92, Issue 1, January 1953, Pages 85–88, https://doi.org/10.1093/infdis/92.1.85 Published: 01 January 1953 Article history Received: 04 August 1952 Published: 01 January 1953
Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin Neurons<i>In Situ</i> (2005)

The physiological signaling mechanisms that link normal variations in body energy status to the activity of arousal- and metabolism-regulating brain centers are not well understood. The melanin-concentrating hormone (MCH) and orexin/hypocretin types of neurons of the lateral hypothalamus (LH) exert opposing effects on arousal and metabolism. We examined whether shifts in brain extracellular glucose that correspond to physiological changes in blood glucose can alter the electrical output of neurochemically and biophysically defined LH cells in mouse brain slices. Here, we show that physiologically relevant concentrations of glucose dose-dependently enhance the electrical excitability of MCH neurons by inducing depolarization and increasing membrane resistance. We also demonstrate that the same physiological shifts in glucose have the opposite effects on the electrical activity of orexin neurons. We propose that these direct actions of glucose on the arousal- and metabolism-regulating LH neurons play a key role in the translation of normal variations in body energy resources into appropriate changes in arousal and metabolism.
Modeling and simulation of MISO diversity for UHF RFID communication (2012)

Radio Frequency Identification (RFID) is used in high scattering environments where deep fading exists. This makes diversity particularly interesting for this communication scenario. In this paper the potential of using multiple tag antennas for RFID-communication is shown. The bit error rate (BER) and packet error rate (PER) is presented, which include the backscattering answer of a RFID-Tag according to the EPC Class-1 Gen-2 protocol. The rates are regarded in combination with the relevant fading channel models for RFID communication such as the Rician- and the Dyadic Backscatter Channel. It is shown that the possible diversity gain from the signal according to EPC Class-1 Gen-2 protocol is several dB regarding the error rates. It is also shown that this diversity gain increases with the correlation of the forward and backward link and decreases with the usage of a more robust encoding scheme and a correlation between the several transmission paths. Additionally the performance of Multiple Input Single Output (MISO) system with different spatial and forward/backward correlation situations is regarded to have a detailed view on a correlated RFID transmission system using diversity. The performance of this model is verified, using simulations of this propagation system.