gebhart/patrepeval huggingface dataset:
Combination urea and salicyclic acid ointment nail avulsion in nondystrophic nails: a follow-up observation. (1980)

Following the initial report by Farber and South on nonsurgical nail avulsion with urea ointment and their emphasis that the therapy was not helpful in treating nondystrophic nails, we utilized a similar therapy to treat a sixty-seven year old patient who had severe arteriosclerotic cardiovascular disease and relatively nondystrophic but symptomatic large toenail disease. Because their formulation was ineffective on nondystrophic nails, a formulation with an additive, 20 percent urea and 10 percent salicylic acid preparation was used. After a period of two weeks of occlusive paplication, painless nonsurgical avulsion was achieved. Moderate maceration of surrounding skin was temporary and relatively asymptomatic.
Circulating Vitamin D Metabolites, Polymorphism in Vitamin D Receptor, and Colorectal Adenoma Risk (2004)

Higher serum 25(OH)D levels were associated with decreased adenoma risk. Serum 1,25(OH)(2)D and VDR TaqI genotype were not associated with adenoma risk.
DOMeMan : Repräsentation, Verwaltung und Nutzung von digitalen Objektgedächtnissen (2013)

Diese Arbeit beschäftigt sich mit der Frage, wie eine Infrastruktur für digitale Objektgedächtnisse aussehen muss. Ziel der Arbeit ist die Erstellung eines Architekturkonzepts für die Repräsentation und die Verwaltung von, sowie den Zugriff auf digitale Objektgedächtnisse inklusive abgestimmter Werkzeuge, die die Erstellung neuer und die Migration bestehender Systeme erleichtern. Aufgrund der heterogenen Datenlandschaft in einem "open-loop"-Szenario, werden an ein Objektgedächtnis besondere Anforderungen gestellt. Zum einen muss es flexible genug ausgelegt sein, um mit den unterschiedlichsten Daten umgehen zu können. Zum anderen muss ein einfacher und strukturierter Zugriff auf die Daten ermöglicht werden, der je nach Anwendungsfall auch mit Konzepten des Rechte- und Rollen-basierten Zugriffs und der Versionsverwaltung ergänzt werden muss. Diese Arbeit zeigt daher zuerst ein Datenmodell zur Strukturierung von Objektgedächtnisdaten. Dieses erlaubt mit Hilfe von Metadaten auch in heterogenen Szenarien einen Domänen-übergreifenden Datenaustausch. Im Anschluss wird eine Softwarearchitektur vorgestellt, die eine Speicher- und Zugriffslösung für Objektgedächtnisse anbietet und die Gedächtnisse zusätzlich mit einer Aktivitätskomponente ausstattet. Abgerundet wird das Konzept mit einem Satz an Werkzeugen, die es Entwicklern erlauben, zum Beispiel bestehende Datenbestände zu migrieren, neue Strukturen auf Basis von semantischen Daten aufzubauen und diese mit anwendungsspezifischen Visualisierungen dem Benutzer wieder zugänglich zu machen.
Multigene expression of protein complexes by iterative modification of genomic Bacmid DNA (2009)

1. Use of bipartite selections can significantly improve selection of modified bacterial artificial chromosomes carrying baculovirus DNA. Furthermore this approach is sufficiently robust to allow routine modification of the virus genome. 2. In addition to the commonly used p10 and polyhedrin loci, the ctx, egt, 39k, orf51, gp37, iap2 and odv-e56 loci in AcMNPV are all suitable for the high level expression of heterologous genes. 3. Two protein, four protein and eight protein complexes including virus-like particles and cellular chaperone complexes can be produced using the new approach.
Gaussian sliding window for robust processing laser speckle contrast images (2019)

The laser speckle contrast analysis (LASCA) is one of the most applicable tools in microcirculation studies. While the basic idea, as well as experimental setup for this method, are fairly simple, there is still the room for advancing of data processing algorithms. Specifically, the conventional realizations of LASCA method may limit the spatial and/or temporal resolution and thus fail in the detection of very small contrast objects since they based on the fixed-size rectangular sliding window function. We suggest an alternative data processing algorithm based on the usage of the Gaussian sliding filter for a sequential determination of both spatial and temporal parts of the speckle contrast. The suggested replacement of conventional box filter leads to the monotonic damping of high-frequency spectral components that results in a better elimination of ringing and aliasing effects in the spatio-temporal speckle contrast outputs. Additionally, we show that such sliding filtration increases robustness with respect to the processing of a sequence of nonstabilised images. We support this consideration with representative examples of processing both surrogate and real experimental data.
The Effects of Filtering and Limiting a Double-Binary PSK Signal (1969)

This paper describes a digital computer simulation of a double-binary phase-shift keying system. This simulation program is used to investigate the effects of limiting action and of the shape and bandwidth of the filter on the system performance, expressed in terms of error probability
Small-area variations in the treatment of prevalent medical conditions (1995)

This article presents a small-area variation study that examines utilization differences for primary care physicians (PCPs) in treating a homogeneous set of prevalent medical conditions. The study used secondary data collected over a 24-month period from a large, Northeastern region independent practice association. The diagnostic cluster methodology was used to examine geographic differences for PCPs in treating prevalent medical conditions. This methodology groups International Classification of Diseases, 9th revision (ICD-9), codes into diagnostic clusters based on clinical homogeneity with respect to generating a similar clinical response from the physician. For each diagnostic cluster, diagnostic episode clusters (DECs) were formulated. Each DEC links all services incurred in treating a patient's medical condition within a specific period of time. Differences in use rates across small areas were tested using t tests. The data showed little variation in the physician office visit rate across small areas. However, services generated from these office visits exhibited large rate variations. The most significant small-area differences were for hospital inpatient days and surgical procedures. Pattern-of-treatment differences exist across small areas for the homogeneous set of prevalent medical conditions treated by PCPs.
Enhancing effect of cetyl lactate on the percutaneous absorption of indomethacin in rats. (1989)

The enhancing effect of cetyl lactate (CL) on the percutaneous absorption of indomethacin (ID) from test solutions in propylene glycol (PG) was investigated by using the abdominal skin of rats in vivo. The percutaneous absorption rate of ID from 1 or 3% CL-PG test solution through the intact skin of rats was observed to be faster than that from the control solution (without CL). The bioavailability of ID was about 0.04% for the control solution, 2.2% for 1% CL-PG and 6.8% for 3% CL-PG test solutions. These results suggest that CL functions as an enhancer for the percutaneous absorption of ID. Furthermore, marked enhancing effects on percutaneous absorption of ID were obtained at a concentration greater than 1% CL in PG. In order to elucidate the mode of action of CL as an absorption enhancer, the percutaneous absorption of ID from the control solution and 3% CL-PG test solution through damaged skin from which the stratum corneum had been stripped was additionally investigated. It was confirmed that CL acts on the stratum corneum to produce its effect.
n-Type conjugated electrolytes cathode interlayer with thickness-insensitivity for highly efficient organic solar cells (2017)

These two small conjugated electrolytes with self-doping effect and thick-insensitivity (>30 nm), a notable PCE of 10.2%.
The Munich LSTM-RNN Approach to the MediaEval 2014 "Emotion in Music" Task (2014)

In this paper we describe TUM’s approach for the Medi-aEval’s “Emotion in Music ” task. The goal of this task is to automatically estimate the emotions expressed by mu-sic (in terms of Arousal and Valence) in a time-continuous fashion. Our system consists of Long-Short Term Mem-ory Recurrent Neural Networks (LSTM-RNN) for dynamic Arousal and Valence regression. We used two different sets of acoustic and psychoacoustic features that have been previ-ously proven as effective for emotion prediction in music and speech. The best model yielded an average Pearson’s cor-relation coefficient of 0.354 (Arousal) and 0.198 (Valence), and an average Root Mean Squared Error of 0.102 (Arousal) and 0.079 (Valence).
Late Quaternary environmental and climatic changes in central Europe as inferred from the composition of organic matter in annually laminated maar lake sediments (2004)

Geochemical (elemental analysis, bulk δ 13 C TOC , thermal degradation techniques, molecular analysis of n ‐alkanes) and microscopic investigations (maceral analysis, vitrinite reflectance) were performed (1) to characterize the organic matter (OM) in sediments from two maar lakes in the Westeifel volcanic field, Germany, and (2) to discuss paleoenvironmental processes which have controlled the accumulation and preservation of OM. The annually laminated sediments show a wide range of organic carbon contents between 0.3 and 21.4% TOC and Hydrogen Index values between 80 and 501 mg HC/g TOC. Well‐developed laminations mirror suboxic to anoxic bottom waters. Diagnostic compounds in the pyrolysates and microscopic analysis permit discrimination between the principal OM sources, and their variations over time provide important evidence for the reconstruction of the environmental histories of the lakes and their watershed. The significance of terrigenous OM is reflected by the occurrence of methoxyphenols in the insoluble as well as mid‐ and long‐chain n ‐alkanes in the soluble OM which are indicative of land plant or macrophyte input to the lakes. The relative abundance of certain homologues together with the amount of terrigenous macerals can be used to show differences in higher plant input and vegetation changes through time. During the Pleniglacial and Younger Dryas period, high‐reflecting reworked OM was introduced by soil erosion in an environment with relatively open vegetation. The alkylphenols in the pyrolysates originate partly from the microbial reworking of proteinaceous tyrosine moieties and/or reflect a direct contribution from cyanobacteria. We assume that variations in the carbon isotopic composition of OM are mainly due to changes in the lake's primary productivity with the exception of the Pleniglacial. Various forms of land use are reflected by increasing amounts of terrigenous particles as well as chemical plant markers from 500 varve years B.P. until present. The organic geochemical and microscopic data correlate well with other proxy information about climate‐dependent fluctuations in the ecosystem of the studied sites.
Photochromic Dithienylethene‐Containing Triarylborane Derivatives: Facile Approach to Modulate Photochromic Properties with Multi‐addressable Functions (2014)

A series of dithienylethene-containing triarylboranes has been designed, synthesized, and characterized. The electrochemistry, photophysics, and photochromic behavior have also been studied. The photophysical and photochromic properties could be facilely tuned in this system by varying the thiophene spacers (thiophene, thienothiophene, and bithiophene) between the dithienylethene and the dimesitylboron (BMes2 ) or the position of the BMes2 substitution in the thiophene spacers. The absorption of closed form has been found to be more sensitive towards the structural modification upon incorporation of the BMes2 unit. Moreover, multi-addressable photochromic reactivity is obtained upon addition of Lewis base (F(-) ), which is due to the formation of boron-Lewis base adduct. The dependence of the photophysical and photochromic properties on the thiophene spacers and the position of the BMes2 substitution has been further supported by computational studies.
A sensitive fluorescence technique using dansyl chloride to assess hair damage (1989)

A simple and sensitive procedure amenable to visual or spectrofluorometric quantitation has been developed to detect certain types of hair damage. We have found that hair treated with the fluorescent dye 1-dimethylamino-naphthalene-5-sulfonyl chloride (dansyl chloride) acquires fluorescence under ultraviolet light. The fluorescence intensity is a function of the amount of dansyl chloride binding to the hair and can be measured in a spectrofluorometer at very low levels. Our studies have shown that changes in the fluorescence emission of dansylated hair indicate hair damage. Using this procedure, we were able to demonstrate statistically significant differences in hair damaged due to (i) weathering, (ii) ultraviolet light, and (iii) chemical bleaching.
Random T-Cell Receptor Recruitment in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8 <sup>+</sup> T Cells from Genetically Identical Twins Infected with the Same HIV-1 Strain (2007)

Human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte escape mutations represent both a major reason for loss of HIV immune control and a considerable challenge for HIV-1 vaccine design. Previous data suggest that initial HIV-1-specific CD8(+) T-cell responses are determined largely by viral and host genetics, but the mechanisms influencing the subsequent viral evolution are unclear. Here, we show a random recruitment of T-cell receptor (TCR) alpha and beta clonotypes of the initial HIV-1-specific CD8(+) T cells during primary infection in two genetically identical twins infected simultaneously with the same virus, suggesting that stochastic TCR recruitment of HIV-1-specific CD8(+) T cells contributes to the diverse and unpredictable HIV-1 sequence evolution.
Phase Change Random Access Memory Devices with Nickel Silicide and Platinum Silicide Electrode Contacts for Integration with CMOS Technology (2011)

10.1149/1.3529354
The prostaglandins: a new factor in fertility control. (1970)

Prostaglandins, substances which are present in many tissues, have a wide variety of biological actions, and they occur in many species. They are fatty acids, and several families can be identified on the basis of their chemical structure. The 1st hurdle to be overcome in the future development of prostaglandins is to synthesize large quantities. At least 1 method is suitable for scaling up to produce large amounts of prostaglandins commercially, and kilo quantities should be available in 1971. The next stage in the progress of prostaglandins will be to learn more regarding the physiology of their action and to expand clinical experience. It was discovered in 1965 that prostaglandins stimulated the human uterus to contract. Since that time they have been used to induce labor or to produce abortion in over 1000 women. Prostaglandins were 1st used to induce abortion in the latter part of 1969. The oral route of administration can be used at term, but when it has been attempted early in pregnancy the results has been serious nausea and vomiting which arises at the dose necessary to terminate pregnancy. Prostaglandins given into the vagina over 2-1/2 hours have terminated pregnancy with fewer side-effects and more rapidly than when given intravenously. The most significant potential of prostaglandins may lie in the production of a once-a-month contraceptive. As yet, prostaglandins have not been registered with any national drug registration authority.
Energy and carbon efficient VM placement and migration technique for green cloud datacenters (2014)

One of the most popular emerging technologies in today's world is Cloud Computing and it is being used widely all over the world by many IT companies as it provides various benefits to the users like cost saving and ease of use. But with the growing demands of users for computing services, cloud providers are encouraged to deploy large data centers which consume very large amount of energy and contribute to high operational costs. Carbon dioxide emission rate is also increasing day by day due to huge amount of power consumption. Therefore, we require to develop techniques which will help to get more environment friendly computing i.e. Green Cloud Computing. Some of the techniques being used in cloud data centers for reducing the operational costs, power consumption and CO2 emission are resource allocation, virtualization and VM migrations. In this paper, we propose a new technique to reduce the carbon emission and energy consumption in the distributed cloud datacenters having different energy sources and carbon footprint rates. Our approach uses the carbon footprints of all the datacenters in distributed cloud architecture and the concept of virtual machine allocation and migration inside each datacenter for reducing the carbon emission and energy consumption in the federated cloud system.
A resonant power MOSFET/IGBT gate driver (2003)

This paper discusses a resonant gate driver that employs a new method of driving a power MOSFET or IGBT. This resonant gate driver recycles the energy stored in the gate capacitance to reduce the CV/sup 2/f losses associated with a conventional gate driver. Reducing the CV/sup 2/f losses reduces the power consumption and hence the subsequent power dissipation in the resonant gate driver. Less power dissipation enables the driver to operate to higher frequencies. In addition, this topology allows the resonant gate driver to drive the MOSFET gate with a much higher peak to peak voltage swing than it is supplied with and to drive the gate negative in its off cycle. The resonant gate driver can drive the gate with a variable frequency and duty cycle, and very fast switching of the power MOSFET is obtained. An introduction into the low loss capacitance driver circuit topology (patent pending) is presented. The design considerations of implementing a practical MOSFET gate driver using this topology are discussed. Practical implications and considerations of using this topology to drive power MOSFETs/IGBTs are briefly put forward. Experimental test circuits and results are then presented.
Permissiveness of human hepatoma cell lines for HCV infection (2012)

We conclude that the restrictions observed later during HCV infection in these cell lines could in part be attributed to HCV-induced innate signaling. Nevertheless, the identification of two new cell lines capable of supporting authentic HCVcc infection, even at reduced levels, expands the current repertoire of cell lines amendable for the study of HCV in vitro and should aid in further elucidating HCV biology and the cellular determinants that modulate HCV infection.
LAPWiN: Location-aided probing for protecting user privacy in Wi-Fi networks (2014)

Efficient Wi-Fi probing has been demonstrated to leak sensitive user information. During the probing process, Wi-Fi clients transmit the names of previously known Wi-Fi access points (APs) in plaintext. An eavesdropper can easily collect the information leaked by this Wi-Fi probing process to mount numerous attacks, such as fake AP or revealing hidden APs, or to breach users' privacy. Since APs are often named after the location, business, or affiliation of the host, an attacker can learn about nearby users and infer social connections. In this work, we propose to reduce the privacy risk while simultaneously decreasing the network connection time by eliminating unnecessary probe requests, most notably those requests sent to networks that are not in proximity of the device. We present a location-aided Wi-Fi probing mechanisms called LAPWiN to achieve these improvements. We demonstrate how LAPWiN can be implemented by modifying a widely used network manager and evaluate the performance and achievable privacy gains.
Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats (2019)

<b>Context:</b> Dexmedetomidine (Dex) has been reported to have an anti-inflammatory effect. However, its role on osteoarthritis (OA) has not been explored. <b>Objective:</b> This study investigates the effect of Dex on OA rat model induced by papain. <b>Materials and methods:</b> The OA Wistar rat model was induced by intraluminal injection of 20 mL of papain mixed solution (4% papain 0.2 mL mixed with 0.03 mol L<sup>-1</sup> l-cysteine 0.1 mL) into the right knee joint. Two weeks after papain injection, OA rats were treated by intra-articular injection of Dex (5, 10, or 20 μg kg<sup>-1</sup>) into the right knee (once a day, continuously for 4 weeks). Articular cartilage tissue was obtained after Dex treatment was completed. <b>Results:</b> The gait behavior scores (2.83 ± 0.49), PWMT (15.2 ± 1.78) and PTWL (14.81 ± 0.92) in H-DEX group were higher than that of OA group, while Mankin score (5.5 ± 0.81) was decreased (<i>p</i> < 0.05). Compared with the OA group, the IL-1β (153.11 ± 16.05 pg mg<sup>-1</sup>), IL-18 (3.71 ± 0.7 pg mg<sup>-1</sup>), IL-6 (14.15 ± 1.94 pg/mg) and TNF-α (40.45 ± 10.28 pg mg<sup>-1</sup>) levels in H-DEX group were decreased (<i>p</i> < 0.05). MMP-13, NLRP3, and caspase-1 p10 expression in Dex groups were significantly lower than that of OA group (<i>p</i> < 0.05), while collagen II was increased (<i>p</i> < 0.05). p65 in the nucleus of Dex groups was significantly down-regulated than that of OA group (<i>p</i> < 0.05). <b>Discussion and Conclusions:</b> Dex can improve pain symptoms and cartilage tissue damage of OA rats, which may be related to its inhibition of the activation of NF-κB and NLRP3 inflammasome.
Space-efficient simulation of quantum computers (2009)

Traditional algorithms for simulating quantum computers on classical ones require an exponentially large amount of memory, and so typically cannot simulate general quantum circuits with more than about 30 or so qubits on a typical PC-scale platform with only a few gigabytes of main memory. However, more memory-efficient simulations are possible, requiring only polynomial or even linear space in the size of the quantum circuit being simulated. In this paper, we describe one such technique, which was recently implemented at FSU in the form of a C++ program called SEQCSim, which we releasing publicly. We also discuss the potential benefits of this simulation in quantum computing research and education, and outline some possible directions for further progress.
Measuring magnetic fields in space (1967)

Abstract Nuclear magnetometers, viz. rubidium and proton magnetometers, are especially suited for accurate measurements of the earth's field from rockets. A description is given of the working principles of these instruments from the viewpoint of their application in space research, including the special measures required to preserve instrumental accuracy in the magnetic environment of the rocket.
High-Performance Lithium Metal Negative Electrode with a Soft and Flowable Polymer Coating (2016)

The future development of low-cost, high-performance electric vehicles depends on the success of next-generation lithium-ion batteries with higher energy density. The lithium metal negative electrode is key to applying these new battery technologies. However, the problems of lithium dendrite growth and low Coulombic efficiency have proven to be difficult challenges to overcome. Fundamentally, these two issues stem from the instability of the solid electrolyte interphase (SEI) layer, which is easily damaged by the large volumetric changes during battery cycling. In this work, we show that when a highly viscoelastic polymer was applied to the lithium metal electrode, the morphology of the lithium deposition became significantly more uniform. At a high current density of 5 mA/cm2 we obtained a flat and dense lithium metal layer, and we observed stable cycling Coulombic efficiency of ∼97% maintained for more than 180 cycles at a current density of 1 mA/cm2.