gebhart/patrepeval huggingface dataset:
Serum beta-human chorionic gonadotropin, estradiol and progesterone as early predictors of pathologic pregnancy. (1992)

We prospectively studied 110 asymptomatic female infertility patients with serial serum measures of beta-human chorionic gonadotropin (hCG), estradiol (E2) and progesterone (P) to determine their sensitivity, specificity, predictive value and test efficiency, alone or in combination, for the prediction of pathologic gestations prior to five weeks after ovulation. Circulating levels of serum beta-hCG, E2 and P were measured at 48- or 72-hour intervals. Seventy-four patients (67%) had viable pregnancies, for which the abnormal changes in steroid levels were defined as: a beta-hCG rise of less than 66% in 48 hours or less than 120% in 72 hours, an E2 decline of greater than 15% in 48 hours or greater than 20% in 72 hours, or a P decline of greater than 25% in 48 hours or greater than 33% in 72 hours. Thirty-six women (33%) had pathologic pregnancies, which included ectopic pregnancies (8), spontaneous or missed abortions (7), blighted ova (anembryonic gestation, 20) and hydatidiform mole (1). For the detection of pathologic pregnancies in this asymptomatic infertility population, the sensitivity of beta-hCG, E2 and P, singly or in combination, ranged from 34% to 78%, and the test efficiency ranged from 68% to 88%. Beta-hCG alone provided the highest sensitivity (78%) and test efficiency (88%). When compared to measuring serial beta-hCG alone, serum E2 or P did not enhance the test efficiency and lowered the sensitivity for the detection of pathologic pregnancies in an asymptomatic infertility population.
The response regulator SsrB activates expression of diverse <i>Salmonella</i> pathogenicity island 2 promoters and counters silencing by the nucleoid‐associated protein H‐NS (2007)

The two-component system SsrA-SsrB activates expression of a type III secretion system required for replication in macrophages and systemic infection in mice. Here we characterize the SsrB-dependent regulation of genes within Salmonella pathogenicity island 2 (SPI-2). Primer extension and DNase I footprinting identified multiple SsrB-regulated promoters within SPI-2 located upstream of ssaB, sseA, ssaG and ssaM. We previously demonstrated that ssrA and ssrB transcription is uncoupled. Overexpression of SsrB in the absence of its cognate kinase, SsrA, is sufficient to activate SPI-2 transcription. Because SsrB requires phosphorylation to relieve inhibitory contacts that occlude its DNA-binding domain, additional components must phosphorylate SsrB. SPI-2 promoters examined in single copy were highly SsrB-dependent, activated during growth in macrophages and induced by acidic pH. The nucleoid structuring protein H-NS represses horizontally acquired genes; we confirmed that H-NS is a negative regulator of SPI-2 gene expression. In the absence of H-NS, the requirement for SsrB in activating SPI-2 genes is substantially reduced, suggesting a role for SsrB in countering H-NS silencing. SsrB activates transcription of multiple operons within SPI-2 by binding to degenerate DNA targets at diversely organized promoters. SsrB appears to possess dual activities to promote SPI-2 gene expression: activation of transcription and relief of H-NS-mediated repression.
Evaluation of cellulose ethers for conservation (1990)

A research report resulting from a three-year study on the stability of cellulose ethers, conducted at the Mellon Institute of Research, Carnegie Mellon University. The authors describe the chemical character of cellulose ethers as a general class of polymer and establish an approximate ranking of the stability of each generic chemical subclass. Cellulose ethers have attracted considerable interest among conservation professionals, but only limited information has been available concerning their potential long-term thermal and photochemical stability. This study reviews the physical and chemical properties of cellulose ethers as reported in the technical literature and presents laboratory research to support the ranking of eight generic classes of cellulose ethers with respect to thermally-induced discoloration, weight loss, loss of polymerization, and formation of peroxides. In the course of this research, individual commercial products of the same generic class were not compared or evaluated, nor was their effectiveness judged for use in conservation. However, a number of simple test methods are described that may be used by conservators to compare the relative stability of specific commercial products. -- AATA
HMM-based frequency bandwidth extension for speech enhancement using line spectral frequencies (2004)

A new hidden Markov model (HMM) based frequency bandwidth extension algorithm using line spectral frequencies (HMM-LSF-FBE) is proposed. The proposed algorithm improves the performance of the traditional LSF-based extension algorithm by exploiting an HMM to indicate the proper representatives of different speech frames, and by applying a minimum mean square criterion to estimate the high-band LSF values. The proposed algorithm has been tested and compared to the traditional LSF-based algorithm in terms of the perceptual evaluation of speech quality (PESQ) objective measure and speech spectrograms. Simulation results show that the proposed algorithm outperforms the traditional method by eliminating undesired whistling sounds completely. In addition, the bandwidth extended speech signals created by the proposed algorithm are significantly more pleasant to the human ear than the original narrowband speech signals from which they are derived.
NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. (1994)

The yeast HIS3 TR and TC TATA elements support basal transcription, but only TR can respond to transcriptional activators. Four genes, NOT1(CDC39), NOT2(CDC36), NOT3, NOT4, act as general negative regulators and preferentially affect TC-dependent transcription. Allele-specific suppression, a two-hybrid interaction, and biochemical confractionation suggest that NOT1 and NOT2 are nuclear proteins associated in a discrete, 500-kD complex. NOT4 interacts with NOT1 and NOT3 in the two-hybrid assay, and overexpression of NOT3 or NOT4 suppresses not1 and not2 mutations. Repression by the NOT proteins is not attributable to inhibition of transcriptional activators, does not involve the CYC8/TUP1 negative regulatory complex, and is distinct from repression by nucleosomes or by the SPT4, 5, 6 proteins that affect chromatin structure. We propose that the NOT protein inhibit the basic RNA polymerase II transcription machinery, possibly by affecting TFIID function.
A Modified Stripe-RGBW TFT-LCD with Image-Processing Engine for Mobile Phone Displays (2007)

This paper presents a modified stripe-RGBW (MS-RGBW) color filter structure to keep the same high resolution, and obtain a higher brightness in comparison with conventional RGB color filters. An image-processing engine is also designed to achieve sharp text image for thin-film-transistor (TFT) LCD with the MS-RGBW color filter. In MS-RGBW color filter structure, each pixel with three sub-pixels is the same area to that in the conventional RGB stripe color filter, and each row shifts two sub-pixels. The image-processing engine consists of two new algorithms: RGB-RGBW mapping algorithm and sub-pixel rendering algorithm. The RGB-RGBW mapping algorithm obtains a new RGBW image data without distortion in hue and saturation. The sub-pixel rendering algorithm transfers RGBW data into a MS-RGBW color filter structure in order to achieve sharp text image. Numerous simulation results are provided to illustrate the merits and performance of the proposed techniques. The usefulness of the proposed techniques for mobile phone displays is exemplified by conducting several experimental results on a 2.2-inch TFT LCD.
CONTEXTUALISING THE FEMININE (2010)

The Greek novel occupies a special place in the debate on gender in antiquity, forcing us to ask why the female protagonists are such strong and positive characters. This book rejects the hypothesis of a largely female readership, and also sees a problem in ascribing this pattern to the reflection of a blanket improvement in the status of women. Katharine Haynes shows that the strong heroines are best understood not as an undistorted mirror on an improved social reality, but as a type of 'constructed feminine'.The book offers a wealth of fascinating insights into the kaleidoscopic world of male and female in the Greek novel, which will inform and illuminate the reader whatever the text being studied. The related issues of ethnicity and self-definition also explored will be of interest for all those working on ancient fiction or the culture of the Second Sophistic
Collagen binding activity of recombinant and N‐terminally modified annexin V (anchorin CII) (1995)

We have cloned the full coding cDNA sequence of chicken annexin V and of a mutant lacking 8 amino acid residues of the N-terminal tail for prokaryotic expression. Both proteins were synthesized in Escherichia coli upon induction with isopropyl thio-beta-D-galactoside, and were purified following two different protocols: one based on the ability of these proteins to interact reversibly with liposomes in the presence of calcium, and the other based on two sequential ion-exchange chromatographic steps. Spectroscopical analysis of recombinant annexin V revealed that binding of calcium did not change the circular dichroism spectra indicating no significant changes on the secondary structure; however, a conformational change affecting the exposition to the solvent of the tryptophan residue 187 was detected by analysis of fluorescence emission spectra. Recombinant annexin V binds with high affinity to collagen types II and X, and with lower affinity to collagen type I in a calcium-independent manner. Heat denaturing of collagen decreases this interaction while pepsin-treatment of collagen almost completely abolishes annexin V binding. Mutated annexin V interacts with collagen in a similar way as the nonmutated recombinant protein, indicating that the N-terminal tail of annexin V is not essential for collagen binding.
SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. (1994)

The yeast Snf1p kinase is required for normal expression of many genes involved in utilization of non-glucose carbon. Snf1p is known to associate with several proteins. One is Sip1p, a protein that becomes phosphorylated in the presence of Snf1p and thus is a candidate Snf1p kinase substrate. We have isolated the SIP1 gene as a multicopy suppressor of the gal83-associated defect in glucose repression of GAL gene expression. Multicopy SIP1 also suppressed the gal82-associated defect in glucose repression, suggesting that SIP1, GAL83 and GAL82 function interdependently. Multicopy SIP1 gene reduces GAL1, GAL2, GAL7 and GAL10 gene expression three- to fourfold in cells grown in the presence of glucose but has no effect in cells grown on nonrepressing carbon. Sip1-deletion cells exhibited a two- to threefold increase in GAL gene expression compared to wild-type cells when grown on glucose. These studies show that SIP1 is a catabolite repression-specific negative regulator of GAL gene expression. Northern analysis revealed two SIP1 transcripts whose relative abundance changed with carbon source. Western blots revealed that Sip1p abundance is not markedly affected by carbon source, suggesting that Sip1p may be regulated post-translationally.
Securing SQL Server (2018)

Use this book to safeguard your data through a defense-in-depth strategy for protecting your SQL Server database estate. Perform threat-analysis, implement countermeasures to common attacks, employ new features such as data masking, and comply with regulatory requirements such as the GDPR.
Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development (2007)

Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3, Fli1+12, and Scl+19, that operates during specification of hematopoiesis in the mouse embryo. We show that the Fli1+12 enhancer, like the Gata2-3 and Scl+19 enhancers, targets hematopoietic stem cells (HSCs) and relies on a combination of Ets, Gata, and E-Box motifs. We show that the Gata2-3 enhancer also uses a similar cluster of motifs and that Gata2, Fli1, and Scl are expressed in embryonic day-11.5 dorsal aorta where HSCs originate and in fetal liver where they multiply. The three HSC enhancers in these tissues and in ES cell-derived hemangioblast equivalents are bound by each of these transcription factors (TFs) and form a fully connected triad that constitutes a previously undescribed example of both this network motif in mammalian development and a GRN kernel operating during the specification of a mammalian stem cell.
Inexpensive and Highly Reproducible Cloud-Based Variant Calling of 2,535 Human Genomes (2015)

Population scale sequencing of whole human genomes is becoming economically feasible; however, data management and analysis remains a formidable challenge for many research groups. Large sequencing studies, like the 1000 Genomes Project, have improved our understanding of human demography and the effect of rare genetic variation in disease. Variant calling on datasets of hundreds or thousands of genomes is time-consuming, expensive, and not easily reproducible given the myriad components of a variant calling pipeline. Here, we describe a cloud-based pipeline for joint variant calling in large samples using the Real Time Genomics population caller. We deployed the population caller on the Amazon cloud with the DNAnexus platform in order to achieve low-cost variant calling. Using our pipeline, we were able to identify 68.3 million variants in 2,535 samples from Phase 3 of the 1000 Genomes Project. By performing the variant calling in a parallel manner, the data was processed within 5 days at a compute cost of $7.33 per sample (a total cost of $18,590 for completed jobs and $21,805 for all jobs). Analysis of cost dependence and running time on the data size suggests that, given near linear scalability, cloud computing can be a cheap and efficient platform for analyzing even larger sequencing studies in the future.
Electrical breast stimulation. Oxytocin, prolactin and uterine response. (1993)

Electrical breast stimulation using a modified electromyograph was performed on 10 pregnant women between 38 and 42 weeks of gestation. An adequate uterine contraction pattern (at least three contractions lasting > or = 30 seconds in a 10-minute interval either recorded by external tochodynamometry, palpated and/or felt by the patient) was obtained in 8 of the 10. Two patients, however, had uterine hyperstimulation (contractions lasting > 90 seconds). In contrast to previous reports, serum oxytocin levels increased significantly in 7 of the 10 patients. Moreover, this increase preceded or was concomitant with the uterine contractions. Serum prolactin varied unpredictably following electrical breast stimulation. The stimulation was well tolerated, without any discomfort, by all the patients. Electrical breast stimulation can thus be used for the stimulation of uterine contractions.
Application of smart antenna technologies in simultaneous wireless information and power transfer (2015)

Simultaneous wireless information and power transfer (SWIPT) is a promising solution to increase the lifetime of wireless nodes and hence alleviate the energy bottleneck of energy constrained wireless networks. As an alternative to conventional energy harvesting techniques, SWIPT relies on the use of radio frequency signals, and is expected to bring some fundamental changes to the design of wireless communication networks. This article focuses on the application of advanced smart antenna technologies to SWIPT, including multiple-input multiple-output and relaying techniques. These smart antenna technologies have the potential to significantly improve the energy efficiency and also the spectral efficiency of SWIPT. Different network topologies with single and multiple users are investigated, along with some promising solutions to achieve a favorable trade-off between system performance and complexity. A detailed discussion of future research challenges for the design of SWIPT systems is also provided.
Design and Modeling of a Novel Transformable Land/Air Robot (2019)

This paper describes a novel transformable land/air robot that is capable of terrestrial locomotion and aerial locomotion. What is unusual about the robot is that it can transform between the two modes of locomotion at will through the transformable mechanism, allowing the robot to overcome large obstacles in their mission environment. The wheel mechanism of the robot is shared by both terrestrial and aerial locomotion, instead of simply adding a quadrotor to a wheeled mobile robot. The objective of this paper is to design the robot and establish the kinematic and dynamic models for the transformable process. Herein, we focus on the design of the driving wheels and transformable mechanism. A series of experiments about the energy analysis and the transformation from aerial locomotion mode to terrestrial locomotion mode were performed with the physical prototype; the experiment results confirmed the validity of our design and the theoretical analysis that are helpful to optimize the key parameters in our design. Moreover, our work can provide a reference for the study of the flying car.
A comprehensive model for inversion layer hole mobility for simulation of submicrometer MOSFET's (1991)

A comprehensive model of effective (average) mobility and local-field mobility for holes in MOSFET inversion layers is presented. The semiempirical equation for effective mobility, coupled with the new local-field mobility model, permits accurate two-dimensional simulation of source-to-drain current in MOSFETs. The model accounts for the dependence of mobility on transverse and longitudinal electric fields, channel doping concentration, fixed interface charge density, and temperature. It accounts not only for the scattering by fixed interface charges, and bulk and surface acoustic phonons, but it also correctly describes screened Coulomb scattering at low effective transverse fields (near threshold) and surface roughness scattering at high effective transverse fields. The model is therefore applicable over a much wider range of conditions compared to earlier reported inversion layer hole mobility models while maintaining a physically based character.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New magneto-optic memory concept based on compensation wall domains (1973)

A new concept of thermomagnetic localized reversible magneto-optic storage is proposed based on the application of compensation wall domains (CWD). Individual CWD's of 12 × 12-μm dimensions in an LPE film of composition Y2.34Gd0.52Yb0.14Fe3.74Ga1.26 O12 with 3-μm thickness have been switched by laser flashes of 10−2 erg/μm2 energy in 5 μs at 5145-Å wavelength using a stationary field of 41 Oe normal to the film plane.
Current and Experimental Antibody-Based Therapeutics: Insights, Breakthroughs, Setbacks and Future Directions (2012)

The premise of targeted therapy was born from an intimate understanding of the unique biological pathways and endpoints which are implicated in the development of different disease states and conditions. In addition, the identification of the most appropriate drugs to use for targeted drug therapy has aided in growing interest of the pharmaceutical industry to allocate more resources to monoclonal antibody (mAb) therapeutics. This being the case, it is important to understand antibody based therapeutics, some of the currently Food and Drug Administration (FDA)-approved mAbs in different disease states, as well as the future direction of mAb therapies. In this article, we will provide a critical overview, and discuss a selection of antibody based therapeutics, including their bioengineered structural and functional elements. Furthermore, a segment of the currently FDA-approved mAb antibody therapies, those in research, or in investigation for disease states and conditions ranging from autoimmune disease, inflammatory response, immunosuppression, cancer, including antibody-drug conjugates, immunotherapy, and exciting prospects for antiplatelet and antithrombotic monoclonal antibody therapeutics will be reviewed. Finally, we will discuss our predictions and aspirations for the future directions of mAb-based therapeutic interventions.
Pulse spectroscopy system for non-invasive real-time monitoring of the heart beat volume (2010)

The left-ventricular stroke volume is an important direct indicator of the heart efficiency and perfusion of the vessels. Currently a valid measurement of the beat volume can only be implemented by invasive measurements procedures at the hospitals worldwide. Arterial catheterization is limited to intensive care unit (ICU) usage, costly and potential risky. Some available noninvasive methods yield rather an ability to track relative changes. Values delivered by these techniques are highly subjective and controversial . Enhanced pulse spectroscopy and advances in digital signal processing allow reliable measurement of the changes in peripheral blood volume with subsequent estimation of the cardiac output (CO). The aim of the current work was to design a continuous nonivasive system for the absolute monitoring of the heart beat volume (HBV). And eventually prove the validity of this new method by comparing with the standard invasive technique. It was a first trial to achieve a noninvasive measurement of the HBV by the instrumentality of a standard pulse oximeter, advanced signal processing algorithm and single individual calibration. Software algorithm has been tested on ten patients with various disorders of the cardiovascular system. The real-time absolute references of the HBV were obtained via PiCCO catheterization system (Pulsion Medical Systems, Munich, Germany) on the femoral arteries for three patients. Technology presented in this paper faces clinical needs in intensive care unit, internal medicine unit, operative, postoperative and patient recovery areas. The medical relevance of these devices is high.
Preparation of CVD diamond grains by roll milling of diamond films. (1991)

In this paper, preparation of chemical vapor deposition (CVD) diamond grains by roll milling diamond films synthesized by arc discharge plasma jet CVD is described. In this roll milling process, a diamond film is put between metal plates, these are inserted in a thin plastic film case, a diamond film is milled by rolls together with the metal plates. By means of this roll milling technique, it is possible to control sizes of grains produced. Diamond abrasives of #140/170 are often used for grinding wheels. For the purpose of producing the most #140/170 grains from a diamond film, a suitable hardness of metal plates and final distance between metal plates were investigated, and found that a final distance between metal plates which is 1/8-1/15 of a thickness of a diamond film by using stainless steel (SUS304) plates is suitable milling condition. The friability of CVD diamond grains produced by roll milling is intermediate between that of natural diamond grains and commercial synthetic irregular diamond grains. The crystallinity of the diamond grains measure well in terms of X-ray diffraction and Raman spectroscopy.