gebhart/patrepeval huggingface dataset:
Binding characteristics of galactoside-binding lectin (galaptin) from human spleen. (1990)

Binding characteristics of human spleen soluble galactoside-binding protein (galaptin) were studied using simple galactosides, galactose-terminated disaccharides, cluster glycosides containing up to 6 terminal lactosyl residues, bovine serum albumin derivatives containing 7 to 40 lactosyl residues, desialylated serum glycoproteins, and glycopeptides derived thereof as inhibitors in a newly developed binding assay. In this assay, aminohexyl lactoside was attached to divinyl sulfone-activated Sepharose, which was then used to bind 125I-galaptin. Similarly derivatized Sepharose containing mannoside served as a control. The assay is sensitive, maintains linearity in the concentration range of 125I-galaptin tested, and has very low nonspecific binding. The following new findings were made. 1) All the alpha-D-galactopyranosides with non-sugar aglycon were better inhibitors than the corresponding beta-D-galactopyranoside. 2) The S-galactosides were better inhibitors than the corresponding O-galactosides, regardless of the anomeric configuration. 3) Many Gal beta 1-4- and Gal beta 1-3-linked disaccharides were tested. Although the galaptin did not appear to recognize N-acetylglucosamine as a monosaccharide, the presence of this sugar penultimate to galactose increased the binding affinity by as much as 500-fold, as was the case for N-acetyllactosamine. Of a particular importance is the presence of an equatorial 3-OH group on this sugar. We synthesized the 3-deoxy derivative of N-acetyllactosamine and found that it had 50-fold lower binding affinity compared to N-acetyllactosamine. 4) The binding sites of this lectin do not seem to be operating in a cooperative fashion, since synthetic lactose-containing divalent ligands with various inter-galactose distances did not increase the binding affinity significantly.
Generic quantum block compression (2002)

A generic approach for compiling any classical-block-compression algorithm (which works in bounded space and time) into a quantum-block-compression algorithm is presented. Using this technique, compression asymptotically approaching the von Neumann entropy of a qubit source can be achieved. The automatically compiled algorithms are competitive (in time and space complexity) with hand-constructed quantum-block-compression algorithms.
Efficient Generation of 3-D Models Out of Depth Maps (2001)

Depth reconstruction or acquisition with a 3-D camera results in a video sequence where each pixel of a frame is annotated with a depth value. We propose an approach to combine this depth information into a 3-D model of the assumedly static scene. For processing of video, we have to satisfy strong requirements on computational and storage efficiency, incremental processing and handling of uncertainty in the depth maps. Our approach is based on an octree structure. Cells are split until the topology of the scene can be recovered uniquely. A signeddistance function to the nearest surface is computed in the octree vertices. The scene can then be reconstructed by extraction and triangulation of an implicit surface. The depth uncertainty results in boundary conditions for the implicit surface.
Prognostic utility of the breast cancer index and comparison to Adjuvant! Online in a clinical case series of early breast cancer (2011)

This study validates the prognostic performance of BCI in ER+LN- patients. In this characteristically low-risk cohort, BCI classified high versus low-risk groups with ~5-fold difference in 10-year risk of distant recurrence and breast cancer-specific death. BCI and AO are independent predictors with BCI having additive utility beyond standard of care parameters that are encompassed in AO.
An invasive DNA approach toward a general method for portable quantification of metal ions using a personal glucose meter (2012)

We report herein a general methodology for metal ion detection using low-cost, simple, and widely accessible personal glucose meters through an invasive DNA approach.
Antiangiogenic Therapies in Epithelial Ovarian Cancer (2011)

Phase II and early phase III trials have demonstrated that antiangiogenic therapies have significant activity in ovarian cancer. The results of phase III trials in the front-line and recurrent settings will determine the extent of clinical benefit of antiangiogenic therapies in combination with chemotherapy. Antiangiogenic agents have a distinct side effect profile, and further studies are necessary to evaluate how to minimize the incidence of these events and to identify women most likely to benefit from these therapies.
Interleukin-2/interferon-α2a/13-retinoic acid-based chemoimmunotherapy in advanced renal cell carcinoma: results of a prospectively randomised trial of the German Cooperative Renal Carcinoma Chemoimmunotherapy Group (DGCIN) (2006)

We performed a prospectively randomised clinical trial to compare the efficacy of four subcutaneous interleukin-2-(sc-IL-2) and sc interferon-alpha2a (sc-IFN-alpha2a)-based outpatient regimens in 379 patients with progressive metastatic renal cell carcinoma. Patients with lung metastases, an erythrocyte sedimentation rate < or =70 mm h(-1) and neutrophil counts < or =6000 microl(-1) (group I) were randomised to arm A: sc-IL-2, sc-IFN-alpha2a, peroral 13-cis-retinoic acid (po-13cRA) (n=78), or arm B: arm A plus inhaled-IL-2 (n=65). All others (group II) were randomised to arm C: arm A plus intravenous 5-fluorouracil (iv-5-FU) (n=116), or arm D: arm A plus po-Capecitabine (n=120). Median overall survival (OS) was 22 months (arm A; 3-year OS: 29.7%) and 18 months (arm B; 3-year OS: 29.2%) in group I, and 18 months (arm C; 3-year OS: 25.7%) and 16 months (arm D; 3-year OS: 32.6%) in group II. There were no statistically significant differences in OS, progression-free survival, and objective response between arms A and B, and between arms C and D, respectively. Given the known therapeutic efficacy of sc-IL-2/sc-INF-alpha2a/po-13cRA-based outpatient chemoimmunotherapies, our results did not establish survival advantages in favour of po-Capecitabine vs iv-5-FU, and in favour of short-term inhaled-IL-2 in patients with advanced renal cell carcinoma receiving systemic cytokines.
Basic Principles of Digital Subscriber Sets (1981)

The introduction of digital exchanges into the local telephone network in the future will lead to the application of digital subscriber sets, where all speech and signal coding is carried out in the proximity of the telephone. In order to use the two-wire network the problems of digital transmission must be considered together with those of synchronization, signaling, speech conversion, and powering. This paper deals with the basic solutions and shows the concept for a first model of a digital subscriber set.
Reusable and Mediator-Free Cholesterol Biosensor Based on Cholesterol Oxidase Immobilized onto TGA-SAM Modified Smart Bio-Chips (2014)

A reusable and mediator-free cholesterol biosensor based on cholesterol oxidase (ChOx) was fabricated based on self-assembled monolayer (SAM) of thioglycolic acid (TGA) (covalent enzyme immobilization by dropping method) using bio-chips. Cholesterol was detected with modified bio-chip (Gold/Thioglycolic-acid/Cholesterol-oxidase i.e., Au/TGA/ChOx) by reliable cyclic voltammetric (CV) technique at room conditions. The Au/TGA/ChOx modified bio-chip sensor demonstrates good linearity (1.0 nM to 1.0 mM; R = 0.9935), low-detection limit (∼0.42 nM, SNR∼3), and higher sensitivity (∼74.3 µA µM(-1) cm(-2)), lowest-small sample volume (50.0 μL), good stability, and reproducibility. To the best of our knowledge, this is the first statement with a very high sensitivity, low-detection limit, and low-sample volumes are required for cholesterol biosensor using Au/TGA/ChOx-chips assembly. The result of this facile approach was investigated for the biomedical applications for real samples at room conditions with significant assembly (Au/TGA/ChOx) towards the development of selected cholesterol biosensors, which can offer analytical access to a large group of enzymes for wide range of biomedical applications in health-care fields.
Loss of Testicular Orphan Receptor 4 Impairs Normal Myelination in Mouse Forebrain (2007)

Testicular orphan nuclear receptor 4 (TR4) has been suggested to play important roles in the development and functioning of the central nervous system (CNS). We find reduced myelination in TR4 knockout (TR4(-/-)) mice, which is particularly obvious in forebrains and in early developmental stages. Further analysis reveals that CC-1-positive (CC-1+) oligodendrocytes are decreased in TR4(-/-) forebrains. The O4+ signals are also reduced in TR4(-/-) forebrains when examined at postnatal d 7. However, the number and proliferation rate of platelet-derived growth factor receptor alpha-positive (PDGFalphaR+) oligodendrocyte precursor cells (OPCs) remain unaffected in these regions, suggesting that loss of TR4 interrupts oligodendrocyte differentiation. This is further supported by the observation that CC-1+ oligodendrocytes derived from 5-bromo-2'-deoxyuridine incorporating OPCs are significantly reduced in TR4(-/-) forebrains. We also find higher Jagged1 expression levels in axon fiber-enriched regions in TR4(-/-) forebrains, suggesting a more activated Notch signaling in these regions that correlates with previous reports showing that Notch activation inhibits oligodendrocyte differentiation. Together, our results suggest that TR4 is required for proper myelination in the CNS and is particularly important for oligodendrocyte differentiation and maturation in the forebrain regions. The altered Jagged1-Notch signaling in TR4(-/-) forebrain underlies a potential mechanism that contributes to the reduced myelination in the forebrain.
Human recombinant IL-6: clinical promise. (1991)

The biology of interleukin-6 (IL-6) has been extensively reviewed. This article therefore does not repeat in detail how this molecule was discovered and its cDNA cloned, or the molecular mechanisms of its synthesis, its structural features, and its basic biological functions. Instead, three questions are addressed more closely: (i) How is IL-6 involved in various disease states? (ii) Can IL-6 be useful as a diagnostic clinical marker? (iii) Are there good reasons to expect that IL-6, IL-6 derivatives or IL-6 antagonists may eventually be utilized as therapeutic agents?
STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells (2014)

Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The mechanism by which pancreatic cancer cells resist anoikis and metastasize is not well established. Significant proportion of pancreatic cancer cells resisted anoikis when grown under anchorage-independent conditions. The cells that resisted anoikis showed higher migratory and invasive characteristics than the cells that were cultured under anchorage-dependent condition. Interestingly, anoikis-resistant cells exhibited significantly increased expression and phosphorylation of signal transducer and activation of transcription 3 (STAT3) at Tyr 705, as compared to adherent cells. AG 490 and piplartine (PL) induced significant anoikis in anoikis-resistant pancreatic cancer cells. Silencing STAT3 not only reduced the capacity of pancreatic cancer cells to resist anoikis but also reversed its invasive characteristics. Interleukin-6 treatment and overexpression of STAT3 enhanced anoikis resistance and protected the cells from PL-induced anoikis. PL-treated cells completely failed to develop tumors when injected subcutaneously in immune-compromised mice. Moreover, these cells also failed to metastasize when injected intravenously. On the other hand, untreated anoikis-resistant cells not only formed aggressive tumors but also metastasized substantially to lungs and liver when injected intravenously. Metastatic nodules formed by untreated anoikis-resistant cells in lungs exhibited significant phosphorylation of STAT3 at Tyr705. Taken together, our results established the critical involvement of STAT3 in conferring anoikis resistance to pancreatic cancer cells and increased metastasis.
Apache Drill: Interactive Ad-Hoc Analysis at Scale (2013)

Apache Drill is a distributed system for interactive ad-hoc analysis of large-scale datasets. Designed to handle up to petabytes of data spread across thousands of servers, the goal of Drill is to respond to ad-hoc queries in a low-latency manner. In this article, we introduce Drill's architecture, discuss its extensibility points, and put it into the context of the emerging offerings in the interactive analytics realm.
Some phase synchronization algorithms for coherent MIMO radar (2011)

Practical realization of the coherent processing in widely separated multiple-input multiple-output (MIMO) radar systems requires the development of implementable techniques to ensure a common notion of phase among all the distributed radar elements. In this work, we present two effective approaches to achieve phase synchronization in coherent MIMO radar systems. The first one is the master-slave closed-loop approach, which employs a master-slave architecture. This method is very simple, and is particularly suitable for fine phase synchronization. The second one is the round-trip algorithm, which employs an unmodulated beacon signal to travel through all the radar elements in a round-trip manner. These algorithms are both time asynchronous in nature, and they require no a priori establishment of either time or frequency synchronization. Under a similar analytical framework, we mathematically characterize each of these algorithms, and further derive and analyze the statistical properties of the corresponding phase synchronization error.
Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management? (2019)

The existence of a gut-skin axis is supported by increasing evidence, but its translational potential is not widely recognized. Studies linked inflammatory skin diseases to an imbalanced gut microbiome; hence, the modulation of the gut microbiota to improve skin condition seems to be a feasible approach. Today, there is a growing interest in natural products as alternatives to synthetic drugs. In this respect, oral probiotics could be a simple, safe and cheap modality in the therapeutic management of skin inflammation. Unfortunately, very few studies have looked into how probiotic supplementation influences inflammatory skin disorders. The result, though promising, are difficult to implement in clinical practice due to the heterogeneity of the applied supplemental regimen in the different studies. In this Viewpoint, we aim to encourage the conduction of more research in that direction to explore unambiguously the therapeutic potential of oral probiotics in dermatology. We focus on the most common inflammatory skin diseases (atopic dermatitis, psoriasis, rosacea, acne vulgaris) with an associated gut dysbiosis, but we also discuss some less common, but very serious skin pathologies (eg erythema nodosum, pyoderma gangrenosum, hidradenitis suppurativa) that are possibly linked to a disturbed gut flora composition. We dissect the possible mechanisms along the gut-skin axis and highlight novel points where probiotics could interfere in this communication in the diseased state.
Two Poems (1982)

Journal Article Two Poems Get access Joan Board Joan Board Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 31, Issue 139, Spring 1982, Pages 39–40, https://doi.org/10.1093/english/31.139.39 Published: 01 March 1982
Stereoacuity at Distance and Near (2002)

Stereoacuity was not different at distance and near under normal viewing conditions. The conflict between subject knowledge of target proximity and the optically-induced relaxation of accommodation and convergence, or an inaccurate accommodative-convergence response, might have caused poor near-compensated stereoacuity.
Anomalous Absorption of Silicon Nanocrystals in Silicon-rich SiO1.25 Matrix Precipitated by CO2 Laser Annealing (2006)

The structural aspects, the luminescent and optical properties and localized synthesis of 4.2-5.6 nm-nc-Si in Si-rich SiO1.25 film by a direct-writing CO2 laser rapid-thermal-annealing at the ablation threshold intensity of 5.8 kW/cm2 is demonstrated.
Distributed Inter-Cell Interference Coordination based on rate splitting (2010)

We consider distributed Inter-Cell Interference Coordination based on rate splitting and interference cancellation. Link adaptation is performed based on Channel Quality Information both on the desired link and on links towards interference victims. A transmitted message is split into a private and a public part. The private part is decodable only by the intended receiver, whereas the public part is in addition decodable by some interference victims. The receivers run a best-effort interference cancellation algorithm, canceling interfering public signals. A system of two transmission pairs can be analyzed completely. In a network of transmission pairs, representing e.g. a pico/femto-cellular network, we propose a self-organizing rate splitting method, where the network nodes coordinate based on the limited information available at the nodes. Coordination complexity grows linearly with the size of coordination group.
Synthesis cost dictates the commercial viability of lead sulfide and perovskite quantum dot photovoltaics (2018)

A Monte Carlo analysis shows that the present cost of synthesizing colloidal quantum dots (QDs) is prohibitively high for photovoltaic (PV) applications.
Infrared Absorption Spectrum of Silicon Dioxide (1965)

The absorption spectra of fused silica and α‐quartz were investigated in the 2600 to 50 cm −1 wave number region. Only part of the absorption frequency bands of the crystal quartz appeared in the fused state and some of them were shifted to higher wave numbers. The principal absorption frequencies in the fused silica were at 1126, 809, 452, and 200 cm −1 It is proposed that the infrared spectrum of the fused silica results from two vibrating units, of point group T d and D 3 h , simultaneously. In the vitreous state, some of the Si‐O‐Si bonds are disrupted allowing random orientation of the tetrahedral SiO 4 groups (point group T d ). As a consequence of the formation of nonbridging oxygen, the force constant will be increased, as indicated by the shift of the vibrational frequencies to higher values. For every nonbridging oxygen atom formed, the silicon atom previously connected to it would be left with a positive hole. The point group D 3 h is due to such a silicon atom and its v 3 and v 4 modes coincide with the v 3 and v 4 modes of the T d point group.
Lightweight Directory Access Protocol (LDAP) Bulk Update/Replication Protocol (LBURP) (2006)

The Lightweight Directory Access Protocol (LDAP) Bulk
Update/Replication Protocol (LBURP) allows an LDAP client to perform a
bulk update to an LDAP server. The protocol frames a sequenced set of
update operations within a pair of LDAP extended operations to notify
the server that the update operations in the framed set are related in
such a way that the ordering of all operations can be preserved during
processing even when they are sent asynchronously by the client.
Update operations can be grouped within a single protocol message to
maximize the efficiency of client-server communication. The protocol
is suitable for efficiently making a substantial set of updates to the
entries in an LDAP server. This memo provides information for the
Internet community.
Correlation of aqueous and lipid solubilities with flux for prodrugs of 5‐fluorouracil, theophylline, and 6‐mercaptopurine: A potts–Guy approach (1999)

The Potts and Guy equation that has been used to predict permeability coefficients for molecules being delivered from aqueous vehicles has been transformed to accommodate lipid vehicles that are less polar than skin, and polar vehicles that are less polar than water. Solubilities in pH 4.0 aqueous buffer (SAQ), solubilities in isopropyl myristate (SIPM), and molecular weights (MW) of prodrugs of 5-fluorouracil (5-FU), theophylline (Th), and 6-mercaptopurine (6-MP) have been regressed against their fluxes from suspensions in IPM (JM). Seven series (n = 39) of alkylcarbonyloxymethyl (ACOM), alkyloxycarbonyl (AOC), alkylcarbonyl (AC), and alkylaminocarbonyl (AAC) prodrugs were used to determine the best fit to the transformed Potts and Guy equation (eq 6): log JM = x + y log SIPM + (1 - y)log SAQ - z MW. The estimated values for x, y, and z were -0. 193, +0.525, and +0.00364, respectively, with r 2 = 0.945 for n = 39. Inclusion of a miscellaneous series comprised of the parent drugs and a branched alkyl chain prodrug gave an equally good fit only if 6-MP was excluded from the analysis. The best performer (largest JM) in each series was usually correctly identified. The values for x, y, and z were consistent with values obtained by Potts and Guy, but the inclusion of the (l - y)log SAQ term in eq 6 and the value for y, shows that water solubility is almost as important as lipid solubility in predicting flux. There were no significant changes in predicted log JM or xi for each series if their log JM or xi were calculated using y and z coefficients obtained for solutions to eq 6 from which the data for the series had been excluded. This suggests that the data from all the series is homogeneous. Data from Kasting, Smith, and Cooper for SIPM, SPG, and MW of unrelated molecules were regressed against their fluxes from propylene glycol (PG) using eq 7: log JM = x + y log SIPM + (1 - y) log SPG - z MW. The estimated values for x, y, and z were -1.673, +0.599, and +0.00595, respectively, with r 2 = 0.852 for n = 28. These values for x, y, and z are also consistent with those previously reported by Potts and Guy, and, together with the results for fluxes from IPM, show the general utility of the transformed Potts and Guy equation in predicting flux from vehicles other than water and in showing the importance of solubility in a polar solvent as well as a nonpolar solvent in predicting flux.
A two level approach to reactive planning in power systems (1983)

A two level optimization program is presented to solve the problem of reactive source expansion in system planning. The overall problem is decomposed into a non-linear subproblem and a mixed linear integer subproblem. The nonlinear subproblem is similar to the classic optimal power flow problem in power systems, the mixed linear integer problem is of fixed charge type and is solved by a branch and bound technique. The two sub-problems are coupled together by a set of linear inequalities. The two level algorithm has been applied to the IEEE 118 bus system for reactive planning.
Dynamics of freely swimming flexible foils (2012)

We use modeling and simulations guided by initial experiments to study thin foils which are oscillated at the leading edge and are free to move unidirectionally under the resulting fluid forces. We find resonant-like peaks in the swimming speed as a function of foil length and rigidity. We find good agreement between the inviscid model and the experiment in the foil motions (particularly the wavelengths of their shapes), the dependences of their swimming speeds on foil length and rigidity, and the corresponding flows. The model predicts that the foil speed is proportional to foil length to the −1/3 power and foil rigidity to the 2/15 power. These scalings give a good collapse of the experimental data.