gebhart/patrepeval huggingface dataset:
XRCC1 Protein Interacts with One of Two Distinct Forms of DNA Ligase III (1997)

Human DNA ligase III (103 kDa) has been shown to interact directly with the 70 kDa DNA repair protein, XRCC1. Here, the binding sites have been defined. Subcloned fragments of XRCC1 have been expressed and assayed for their ability to associate with DNA ligase III by far Western and affinity precipitation analyses. The C-terminal 96 amino acids of XRCC1 are necessary and sufficient for the specific interaction with DNA ligase III. A similar approach with the 103 kDa DNA ligase III has identified the C-terminal 148 amino acids of this enzyme as containing the binding site for XRCC1. An alternative 96 kDa form of DNA ligase III, abundant in testes, has been described [Chen, J., et al. (1995) Mol. Cell. Biol. 15, 5412-5422]. These two forms of DNA ligase III have identical N-terminal regions but differ toward their C termini and may be alternatively spliced products of the same gene. Antipeptide antibodies directed against the different C termini of the two forms of the enzyme indicate that both of them occur in vivo. The C-terminal region of the 96 kDa derivative of DNA ligase III is not able to interact with XRCC1. These findings indicate that only the larger form of DNA ligase III acts together with XRCC1, suggesting a role for this isoform of the enzyme in base excision repair.
Epigenetic Control of Aging (2010)

Organismal aging and longevity are influenced by many complex interacting factors. Epigenetics has recently emerged as another possible determinant of aging. Here, we review some of the epigenetic pathways that contribute to cellular senescence and age-associated phenotypes. Strategies aimed to reverse age-linked epigenetic alterations may lead to the development of new therapeutic interventions to delay or alleviate some of the most debilitating age-associated diseases.
'Please sir, I want some more': Young people should not have to beg for a liveable income and affordable housing (2012)

Youth homelessness remains a serious problem in Australia and I posit that intergenerational poverty, social inequality, woefully inadequate income support payments and Australia's housing shortage and affordability crisis are contributing factors that are not given enough attention in the discourse around why young people experience homelessness and have difficulty getting and staying out of homelessness.
Disposing of the US Chemical Weapons Stockpile (1989)

A congressional mandate to dispose of the current US stockpile of lethal unitary weapons (Public Law 99-145, Department of Defense Authorization Act of 1986) has international implications and is responsible for a recent major assessment of available disposal alternatives. Eight installations in the continental United States currently host aging stockpiles of chemical warfare agents. The stockpiles are described, the toxicology and physical properties of each agent are characterized, disposal options considered by the US Army are identified, and the role of a programmatic health and environmental assessment in the decision-making process is outlined. Critical findings are that existing community emergency planning and preparedness are inadequate and that communication of risk information requires significant improvement. Measures are under way to address these needs. However, timely disposal of the stockpile entails less of a hazard than continued storage.
Diffusional Mediation of Surface Electron Transfer on TiO<sub>2</sub> (1998)

The results of a kinetic study are reported for cross-surface electron transfer in the reversible oxidation of [OsII(bpy)2(4,4‘-(CO2H)2bpy)](PF6)2 to OsIII surface adsorbed to nanocrystalline TiO2 films on optically transparent ITO (tin-doped indium oxide) electrodes. The kinetics are sensitive to the extent of surface loading. From monolayers adsorbed from CH3CN, a percolation threshold of ∼60% was measured. Adsorption isotherms for [OsII(bpy)2(4,4‘-(CO2H)2bpy)](PF6)2 in EtOH and CH3CN show that surface coverage from EtOH is ∼60% of that from CH3CN at similar adsorbate concentrations. Apparent charge-transfer diffusion coefficients in 0.1 M [N(n-C4H9)4](PF6) in CH3CN measured by chronoabsorptometry are Dapp = 1.4 × 10-9 cm2/s (Γ = 1.1 × 10-10 mol/cm2, CH3CN) and 1.4 × 10-11 cm2/s (Γ = 7 × 10-11 mol/cm2, EtOH). Electron-transfer mediation of the oxidative component of the OsIII/II surface couple occurs in the presence of added Ru(bpy)32+ by stepping the potential past the Ru(bpy)33+/2+ wave. Mediation of both oxidative and reductive components occurs with added Os(bpy)32+. The apparent diffusion coefficient for oxidation of the OsIII/II surface couple in the presence of Ru(bpy)32+ increases linearly with the concentration of added mediator.
Intestinal current measurement for diagnostic classification of patients with questionable cystic fibrosis: validation and reference data (2010)

This comprehensive investigation of CFTR function and genotype underlines the diagnostic value of ICM, especially for confirmation of CF in the absence of two disease-causing CFTR mutations, exclusion of CF despite intermediate sweat test and age groups unsuitable for nasal potential difference measurements. ICM is an important tool for functional assessment in CFTR mutations of unknown clinical relevance.
Increase of gold–Teflon FEP joint strength by removal of deposited aluminum prior to gold deposition for electret applications (1976)

Abstract A new method is described for bonding gold to Teflon FEP, yielding high joint strength without affecting the electrical properties of the virgin polymer material. The method consists of depositing a 1000‐Å aluminum layer onto the Teflon by evaporation, removing it by washing the sample in dilute sodium hydroxide, followed by deposition of gold by evaporation. The tensile shear strength of this composite is in excess of 80 kg/cm 2 , approaching the cohesive strength of Teflon. The desirable electrical properties of Teflon FEP, as measured by isothermal charge decay and thermally stimulated currents methods, are preserved by this method. X‐Ray photoelectron (ESCA) spectra suggest that the modified wetting characteristics and enhanced joint strengths can be attributed in part to the existence of a thin layer of oxygen‐containing hydrocarbon material on the surface of aluminum‐treated Teflon FEP.
Medical Therapies for Inflammatory Bowel Disease (1998)

Inflammatory bowel disease is a spectrum of disorders whose etiology and pathogenesis are unclear. No therapy is standard; many modalities exist for management. New drugs, improved formulations of existing drugs, combination therapy and biologic agents offer more effective relief and maintain disease remission.
Magnetic confinement of radiotherapy beam-dose profiles (2001)

We have used electron and photon beams from the 50 MV electron microtron at UM Hospital together with a large-bore 3.5T superconducting solenoid to demonstrate the magnetic confinement of HE electron and photon beam-dose profiles for typical radiotherapy beams. The HE electron beams in particular exhibit a large reduction in penumbra when entering a tissue-equivalent phantom and, in addition, confinement of the secondary electrons produced by the primary beam. Likewise photon beams show a similar confinement of the dose from secondary electrons. While the results resemble features predicted from Monte Carlo calculations, there are a number of anomalous details in the actual experimental data which serve to illustrate the problems associated with practical clinical implementations. However the data suggest that in certain cases HE electrons may provide a cost-effective alternate to proton or HI radiotherapy beams and, also, improve the dose profile for HE photon beams.
ChemInform Abstract: METALATION OF FERROCENE WITH N‐PENTYLSODIUM. EXAMINATION OF THE REACTION IN THE PRESENCE AND ABSENCE OF N,N,N′,N′‐TETRAMETHYLETHYLENEDIAMINE (TMEDA) (1979)

Abstract Die Umsetzung von Ferrocen (I) mit n‐Penty1natrium (II) in Gegenwart von Tetramethylethylendiamin (TMEDA) führt in nahezu quantitativer Ausbeute zu den Verbindungen (III) und (IV), die in die Trimethylsilylderivate (VI) und (VII) umgewandelt werden.
The language of machines (2003)

When we start to engage machines in conversation, what language will it be? While natural language is our preferred means of communication, natural language processing is by no means trivial. An alternate approach is to look at augmenting Agent Communication Languages with a view to providing a middle ground between for speech-based interaction between man and machine. This paper presents such a system which has been implemented on Media Lab Europe's social robot Joe.
Similarities between large plasmids of Azospirillum lipoferum (1991)

The nitrogen-fixing bacteria, Azospirillum lipoferum and Azospirillum brasilense, contain several large plasmids. Cryptic plasmids of about 150 MDa have only been detected in A. lipoferum strains. The 150 MDa plasmid of A. lipoferum 4B used as probe hybridized with plasmids of comparable size in all A. lipoferum strains. Total DNA of six A. lipoferum strains were digested and hybridized with the p150 probe. Restriction fragment length polymorphism (RFLP) patterns differ from that of strain 4B except for one strain isolated from the same rhizosphere. However, a high number of hybridizing bands in each strain was close to 150 MDa, showing a high degree of similarity between 150 MDa plasmids. This strongly suggests that A. lipoferum 150 MDa plasmids, though not identical, have evolved from a common ancestor and likely constitute a family of plasmids sharing unidentified common functions.
FIBONACCI NUMBERS FOR PALM FOLIAR SPIRALS (1970)

The Fibonacci sequence (1, 1, 2, 3, 5, 8, 13, 21, 34, 55, 89, 144 …) formulated by the Italian mathematician, Leonardo da Pisa has many interesting mathematical properties. One of these is the fairly constant proportion that works out between any two consecutive stages in the sequence excluding, of course, some lower stages. Such a proportion, spoken of as Golden Proportion, exists in many plant species having alternate phyllotaxis. The foliar arrangement in a few species of palms has been critically studied with a view to understanding the mathematics underlying it. Palms display one, two, three, five, eight, or thirteen foliar spirals, and the spirals in a palm may move clockwisely or counter-clockwisely, each species having both types of palms in almost equal proportions. Areca catechu, Arenga pinnata, Borassus flabellifer, Cocos nucifera, Elaeis guineensis, Phoenix canariensis respectively are examples for the above foliar spiral categories. All these numbers synchronise the Fibonacci Numbers, and no palm is known to have foliar spirals numbering 4, 6, 7, 9, 10, 11 or 12. Exceptional species, however, do not show any clear spirals, but their leaves are arranged vertically in two, three, five or eight rows, the numbers again synchronising the Fibonacci stages. A model has been suggested for the arrangement of leaves in any palm crown in which two consecutive leaves have been shown to subtend 137.5 ° between them, and so this angle makes a proportion of 0.618 with the remaining angle (222.5 °) to complete one full revolution. It is this Golden Proportion that is responsible for palm leaves appearing in spirals. An explanation is offered for the apparent reversed situations in the positions of the flower-bunches in the coconuts (in left- and right-spiralled palms) and in the African oil palm. The drawing was prepared by Mr. S. K. De, the Senior Technical Assistant of the above Institute.
Laplace's law of succession and universal encoding (1998)

This correspondence shows that the known "add-half" rule is not asymptotically optimal for predicting the (n+1)st symbol after a sequence of n symbols, whereas the "add-/spl beta//sub 0/" rule, /spl beta//sub 0/=0.50922/spl middot//spl middot//spl middot/is.
Catching Worms, Trojan Horses and PUPs: Unsupervised Detection of Silent Delivery Campaigns (2017)

Author(s): Bum Jun Kwon, Virinshi Srinivas, Amol Deshpande, Tudor Dumitras Download: Paper (PDF) Date: 27 Feb 2017 Document Type: Reports Additional Documents: Slides Video Associated Event: NDSS Symposium 2017 Abstract: The growing commoditization of the underground economy has given rise to malware delivery networks, which charge fees for quickly delivering malware or unwanted software to a large number … Continued
Hidden Markov Models (2001)

Andrew W. Moore Professor School of Computer Science Carnegie Mellon University www.cs.cmu.edu/~awm awm@cs.cmu.edu 412-268-7599 Note to other teachers and users of these slides. Andrew would be delighted if you found this source material useful in giving your own lectures. Feel free to use these slides verbatim, or to modify them to fit your own needs. PowerPoint originals are available. If you make use of a significant portion of these slides in your own lecture, please include this message, or the following link to the source repository of Andrew’s tutorials: http://www.cs.cmu.edu/~awm/tutorials . Comments and corrections gratefully received.
The IBM 1975 Optical Page Reader Part I: System Design (1968)

The IBM 1975 Optical Page Reader, specially built for the Social Security Administration, reads over 200 fonts from quarterly employer reports printed by electric and manual typewriters, business machines, and high-speed printers. Since the SSA has no control over the means used by employers to prepare the reports, many variations in print quality are present. This paper discusses the problems involved in planning and developing a system to read these reports and summarizes the design of the specialized video signal processing circuits and the character recognition logic that are used in the system. Two companion papers treat the latter topics in more detail. Also discussed in the paper is a management information system that permitted detailed analysis of experimental data and accelerated the development process.
Purification and Properties of a Cyotchrome P-450 of a Fungus, Fusarium oxysporum (1983)

A cytochrome P-450 was isolated from a fungus, Fusarium oxysporum, which grew on a medium containing soybean oil as a sole carbon source. It was found as a heme protein that possess lipoxygenase activity, and seemed to exist in the soluble fraction of cell-free extracts. The cytochrome revealed multiplicity and could be separated into a least 3 fractions (A, B, and C). Two of them, termed Fusarium P-450A and -B, were highly purified. The complex of the ferrous Fusarium P-450 with carbon monoxide showed a Soret peak at 447 nm. The properties of the cytochromes (P-450A and -b) were closely similar to each other, the only detectable difference being in the pI (isoelectric point) value (5.2 and 5.0, respectively). The pI and molecular weight (48,000) values together with amino acid composition of Fusarium P-450 were similar to those of other cytochromes P-450 from various sources. Some other spectral properties as well as interactions with various ligands were also studied. Peroxidase or chloroperoxidase activity was not detected with Fusarium P-450.
Comparison of Western Immunoblotting and the C6 Lyme Antibody Test for Laboratory Detection of Lyme Disease (2004)

Three commercial Lyme disease Western immunoblotting (WB) kits and the C6 Borrelia burgdorferi (Lyme) enzyme-linked immunosorbent assay (ELISA) kit were compared using two commercially available performance panels from the Centers for Disease Control and Prevention (CDC) and Boston Biomedica (BBI). Combined, the panels consisted of 52 characterized specimens. Immunoglobulin G (IgG) sensitivity was similar for the three WB products. The BBI and Marblot WBs were more specific for IgG antibodies, while the Virablot was the most sensitive for IgM antibody. The BBI WB was 100% specific for IgM, while Marblot was 97% and Virablot was 77% specific for IgM. The C6 ELISA was found to be 100% sensitive. Four false-positive C6 results were identified in patients that had clinically and microbiologically confirmed Lyme disease but were not detected by the CDC reference methods. No one WB product showed overall superiority. The C6 ELISA shows promise as the first ELISA for Lyme disease that would not require a supplemental test such as a WB.
Evaluation of Blood Tests to Predict Normal Gastric Mucosa (2000)

Although negative H. pylori IgG serology alone in younger patients, and in combination with normal serum pepsinogen I levels in older patients, reliably predicted the presence of normal gastric mucosa, gastroscopy is still recommended for patients over 45 years.
A distributed access protocol for an ATM user-oriented satellite system (2003)

A distributed medium-access control (MAC) protocol, implementing both static and dynamic access to the available channel bandwidth, to be applied to a user-oriented satellite system, is proposed. Preliminary results about the evaluation of the performance obtainable by means of the dynamic access in the presence of various configurations of isochronous traffic loads are presented. These results show the good performance of the proposed protocol and its applicability to the considered environment. It is to be noted that, although the simulative results were obtained under a balanced-traffic assumption, the proposed protocol performs well even under unbalanced load conditions. In fact, a simple analysis of the protocol behavior would show that, for small loads, a given earth station (ES) could dynamically access the whole bandwidth left available by the isochronous calls. Instead, for very high loads, the MAC protocol assures a fair bandwidth sharing among the requesting ESs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An Adaptive Strategy for Quality-Based Data Reduction in Wireless Sensor Networks (2006)

Wireless sensor networks allow fine-grained observations of real-world phenomena. However, providing constant measurement updates incurs high communication costs for each individual node, resulting in increased energy depletion in the network. Data reduction strategies aim at reducing the amount of data sent by each node, for example by predicting the measured values both at the source and the sink node, thus only requiring nodes to send the readings that deviate from the prediction. While effectively reducing power consumption, such techniques so far needed to rely on a-priori knowledge to correctly model the expected values. Our approach instead employs an algorithm that requires no prior modeling, allowing nodes to work independently and without using global model parameters. Using the LeastMean -Square (LMS) adaptive algorithm on a publicly available, real-world (office environment) temperature data set, we have been able to achieve up to 92% communication reduction while maintaining a minimal accuracy of 0.5 degree Celsius.
Calcium Transport Pathways Of Pancreatic Acinar Cells (1989)

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More
Ryanodine‐ and cyclopiazonic acid‐sensitive components in human vas deferens contractions to noradrenaline (1998)

1. The role of calcium stores in noradrenaline- (NA) and caffeine-induced contractions of human vas deferens were investigated using ryanodine and cyclopiazonic acid (CPA) in the presence of the calcium antagonist, nifedipine (1 microM) or in calcium-free/EGTA (1 mM) medium. 2. In either media, NA (100 microM) evoked biphasic contractions of longitudinal muscle and tonic circular muscle contractions. Caffeine (20 mM) evoked longitudinal but not circular muscle contractions. 3. Ryanodine (1-30 microM) or CPA (1-30 microM) inhibited contractions of circular muscle, and the initial but not secondary component of longitudinal muscle contraction to NA. 4. In the presence of nifedipine, pre-exposure to caffeine caused a potentiation of circular muscle, and the initial but not secondary longitudinal muscle contractions to NA. The presence of ryanodine or CPA during the caffeine pre-exposures effectively blocked the potentiation of the initial component and reduced the secondary component of the subsequent responses to NA in longitudinal muscle. 5. In calcium-free media, caffeine pre-exposures had little effect on subsequent NA-induced contractions in circular muscle, but reduced both components in longitudinal muscle. The presence of ryanodine or CPA during caffeine pre-exposures produced no further effects on either component of the subsequent NA-induced contraction in longitudinal muscle. 6 In the presence of nifedipine or in calcium-free media, repeated applications of caffeine evoked contractions in longitudinal muscle which were not blocked by either ryanodine or CPA. 7. These results suggest that circular muscle contraction by NA and the initial component of longitudinal muscle to NA both utilize an intracellular pool of calcium that is triggered via a ryanodine-sensitive mechanism and replenished via a CPA-sensitive Ca2+-ATPase. 8. In longitudinal muscle, both the secondary component of its response to NA and contraction to caffeine appear to involve an unusual but pharmacologically distinct (ryanodine- and CPA-insensitive) pathway. 9. The quiescence to caffeine of circular muscle may be caused by a relative absence of the ryanodine- and CPA-insensitive pathway.
Impact of Moisture and Fluorocarbon Passivation on the Current Collapse of AlGaN/GaN HEMTs (2012)

In this letter, ambient moisture has been identified as a previously unrecognized cause of current collapse in AlGaN/GaN high-electron-mobility transistors. Unpassivated devices exposed to dry air or protected with a hydrophobic passivation, such as vapor-deposited fluorocarbon, showed negligible current collapse under 250-ns pulsed measurements. A mechanism based on the ionization and deionization of the water molecules at the device surface has been proposed to explain this behavior. The use of a hydrophobic passivation to prevent dc-to-RF dispersion works even when it is not directly in contact with the semiconductor surface, which allows the engineering of multistack passivation layers to eliminate current collapse while minimizing parasitic capacitance.