gebhart/patrepeval huggingface dataset:
Cytoplasmic Tails of SialT2 and GalNAcT Impose Their Respective Proximal and Distal Golgi Localization (2006)

Complex glycolipid synthesis is catalyzed by different glycosyltransferases resident of the Golgi complex. Most of them are type II membrane proteins comprising a lumenal, C-terminal domain linked to an N-terminal domain (Ntd) constituted by a short cytoplasmic tail (ct), a transmembrane, and a lumenal stem regions. They concentrate selectively in different sub-Golgi compartments, in an overlapped manner, acting in succession in the addition of sugars to acceptor glycolipids. The Ntds are sufficient to localize glycosyltransferases in the Golgi complex, but it is not clear whether they also confer selective concentration in sub-Golgi compartments. Here, we studied whether the Ntd of SialT2, localized in the proximal Golgi, and the one of GalNAcT, a trans/TGN Golgi-concentrated enzyme, concentrate reporter proteins in the corresponding sub-Golgi compartment. The sub-Golgi concentration of the Ntds fused to spectral variants of the GFP was determined in CHO-K1 cells from their behavior upon addition of brefeldin A. Fluorescence microscopy and subcellular fractionation showed that the SialT2 Ntd concentrates in a proximal sub-Golgi compartment - and that of GalNAcT in TGN elements. Exchanging the transmembrane region and the cts of SialT2 and GalNAcT indicates that information for proximal or distal Golgi concentration is associated with the cts.
Preliminary report: the short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas. (1996)

A pilot study, to assess the therapeutic potential of percutaneous injection of wild-type p53 (wt-p53) in five patients with primary hepatocellular carcinoma is reported. Three of the five patients showed objective tumor response with reduction of the tumor volume on computed tomographic (CT) scan measurements as well as a significant fall of serum alphafetoprotein. Much further work will be needed to elucidate the mechanism of action.
Development of novel nitroxyl radicals for controlling reactivity with ascorbic acid (2009)

Piperidine and pyrrolidine nitroxyl radicals (nitroxide) contain unpaired electrons and have been widely recognized as antioxidants, contrast agents, spin probes, radiation protective agents and polymerization mediators. Nitroxyl radicals can react with free radicals and reductants and their reactivities depend on the basic structure of the nitroxyl radicals themselves. However, reductants easily reduce these radicals and they lose their paramagnetic nature and function. Therefore, the aim of this study was to develop various functional nitroxyl radicals, particularly focusing on stability towards AsA through the improvement of the synthetic route for a series of 2,6-substituted nitroxyl radicals. Tetraethyl-substituted piperidine nitroxyl radical 8 exhibited resistance to AsA reduction and 2,6-dispiro-4',4''-dipyrane-piperidin-4-one-N-oxyl 5 had a second-order rate constant 10-times greater than those of hydroxyl-TEMPO and oxo-TEMPO. The 2,6-substituted compound offers various reactivities towards AsA and the possibility to be used as a new antioxidant, contrast agent and radical polymerizer.
Charge-transfer-featured materials—promising hosts for fabrication of efficient OLEDs through triplet harvesting via triplet fusion (2014)

A charge-transfer-featured naphthalimide derivative with a small exchange energy but a lower lying (3)ππ* state than (3)CT state is found to contribute to triplet harvesting through a P-type rather than an E-type delayed fluorescence, and could act as a quite promising host to achieve highly efficient OLEDs.
On Infrasound Waveguides and Dispersion (2009)

Research Article| July 01, 2009 On Infrasound Waveguides and Dispersion Petru T. Negraru; Petru T. Negraru Southern Methodist University P.O. Box 750395 Dallas, Texas 75206 U.S.A. pnegraru@smu.edu (P. T. N.) Search for other works by this author on: GSW Google Scholar Eugene T. Herrin Eugene T. Herrin Southern Methodist University P.O. Box 750395 Dallas, Texas 75206 U.S.A. pnegraru@smu.edu (P. T. N.) Search for other works by this author on: GSW Google Scholar Seismological Research Letters (2009) 80 (4): 565–571. https://doi.org/10.1785/gssrl.80.4.565 Article history first online: 09 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share MailTo Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation Petru T. Negraru, Eugene T. Herrin; On Infrasound Waveguides and Dispersion. Seismological Research Letters 2009;; 80 (4): 565–571. doi: https://doi.org/10.1785/gssrl.80.4.565 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietySeismological Research Letters Search Advanced Search Waveguides are structures that provide for efficient propagation of waves. One of the earliest applications of a waveguide is the speaking tube, which was used on ships. Propagation in some waveguides leads to dispersion, a phenomenon in which the phase velocity depends on the frequency. Dispersion of elastic and sound waves in solids and liquids has been observed and treated in the scientific literature for a long time (Worzel and Ewing 1948; Pekeris 1948; Ewing et al. 1957). However, in the sub-audible acoustic domain, usually referred to as infrasound (frequencies below 20 Hz), dispersion was recognized... You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
Map-Adaptive Goal-Based Trajectory Prediction (2020)

We present a new method for multi-modal, long-term vehicle trajectory prediction. Our approach relies on using lane centerlines captured in rich maps of the environment to generate a set of proposed goal paths for each vehicle. Using these paths -- which are generated at run time and therefore dynamically adapt to the scene -- as spatial anchors, we predict a set of goal-based trajectories along with a categorical distribution over the goals. This approach allows us to directly model the goal-directed behavior of traffic actors, which unlocks the potential for more accurate long-term prediction. Our experimental results on both a large-scale internal driving dataset and on the public nuScenes dataset show that our model outperforms state-of-the-art approaches for vehicle trajectory prediction over a 6-second horizon. We also empirically demonstrate that our model is better able to generalize to road scenes from a completely new city than existing methods.
Computer-controlled optimization of positive end-expiratory pressure (1986)

Positive end-expiratory pressure (PEEP) is a standard treatment for patients with refractory hypoxemia due to an acute restrictive pathology. The therapeutic range of PEEP can be quite narrow. PEEP therapy has been optimized using invasive variables such as oxygen transport and pulmonary shunt, and noninvasive variables such as compliance; however, the measurements are complex. We constructed a computerized PEEP-optimization system consisting of a Siemens 900C ventilator, Siemens prototype sulfur hexafluoride analyzer, Siemens 940 lung mechanics analyzer, and a DEC 11/23 microcomputer. The user may choose from three different noninvasive PEEP titration algorithms: maximizing static total respiratory system compliance (CTR), maximizing functional residual capacity(FRC)-based compliance (CFRC), and normalizing FRC. The device was tested in six dogs with pulmonary injury induced by oleic acid. The system was constrained to 3-cm H2O PEEP steps at 20-min intervals. The algorithm normalizing FRC reached optimal PEEP levels in 40 min, with a mean difference from the desired FRC of 15 +/- 48 (SEM) ml. This corresponds to a mean percent error of 1.0% +/- 2.63%. The CFRC and CTR algorithms reached optimal PEEP levels in 60 and 40 min, respectively, and maintained a maximal compliance for 85% of the time. This system provides fully automated noninvasive PEEP titration and is flexible enough to incorporate easily any other PEEP titration algorithms. It should improve patient care by guaranteeing that PEEP therapy is truly optimized throughout the patient's recovery.
Secure DHCPv6 Using CGAs (2012)

The Dynamic Host Configuration Protocol for IPv6 (DHCPv6) enables DHCP
servers to pass configuration parameters. It offers configuration
flexibility. If not secured, DHCPv6 is vulnerable to various attacks,
particularly fake attack. This document analyzes the security issues
of DHCPv6 and specifies security mechanisms, mainly using CGAs.
Preparation and characterization of poly(ethylene terephthalate) fabrics treated by blends of cellulose nanocrystals and polyethylene glycol (2007)

Abstract In this study, the coating based on the blends of low molecular weight polyethylene glycol (PEG) and cellulose nano‐crystals (CNC) was introduced to immobilize on the surface of polyethylene terephthalate (PET) fabrics to modify the surface properties of fabrics, and to fabricate comfortable fabrics for formidable climate. Field‐emission scanning electron microscope, attenuated total reflectance Fourier transform infrared spectroscopy, and differential scanning calorimetry (DSC) were employed to study the topography, superficial ingredients, and thermal activity of the finished fabrics. The observation of field‐emission scanning electron microscope and attenuated total reflectance Fourier transform infrared spectroscopy confirmed that the surface of PET fabrics was covered by CNC/PEG1000/PEG600 coating. The transition onset temperature and phase change enthalpy of PET fabrics treated with CNC/PEG1000/PEG600 were at 7.06°C and 11.41 kJ/kg, respectively. Dimensional memory measurement demonstrated that the introduction of CNC caused the deformation percent to decrease by about 41% for PET fabrics covered with CNC/PEG1000/PEG600 coating. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007
Research Update: Enabling ultra-thin lightweight structures: Microsandwich structures with microlattice cores (2015)

We achieve the benefits of large-scale structural hierarchy at the micro-scale by utilizing a self-propagating photopolymer waveguide process to form ultra-thin sandwich structures. A single step forms the microlattice sandwich core and bonds the core to both facesheets, minimizing adhesive mass and manufacturing time, with core thicknesses &lt;2 mm, facesheet thicknesses ranging from 12.7 to 300 μm, areal densities 0.030–0.041 g cm−2, and flexural rigidity per unit width up to 0.62 Nm. This work extends the lightweighting benefit of sandwich structures to lower thicknesses and areal densities that were previously the exclusive domain of monolithic materials.
Characteristics of self-sensing actuation for active control (1996)

The benefits of a collocated sensor actuator pair are well known within the controls community. Generally speaking, collocation offers the use of simple control algorithms with reduced instabilities due to spillover. One method for achieving collocation is the implementation of a ``sentuator`` in which a piezoelectric element functions simultaneously as both a sensor and an actuator. Past work in utilizing a sentuator has primarily been limited to piezoelectric films and patches mounted to flexible structures. Additional papers have provided information and methodology for dealing with the non-linear aspects of a piezoceramic sentuator. The need arises for methods of self-sensing when performing active vibration control of very stiff structures. A method for understanding and using self-sensing lead zirconate titanate stacks for active vibration control is presented. This paper specifically provides a basic understanding of self-sensing methods as applied to stiff structures for the purposes of control. The discussion of the methodology is followed by a simple example in which active vibration control is applied to a model of a boring bar with embedded PZT stacks.
A structured procedure for analysis and design of order pick systems (1996)

Abstract We present a structured procedure for order pick system (OPS) analysis and design that has been established on literature review and interviews with and presentations to OPS experts. In particular, we attempt to include the thinking processes that occur between OPS designers and owners. The design procedure and related issues are discussed in the order of input, selection, and evaluation stages.
Synthesis of Naturally Occurring, Conformationally Restricted Oxazole‐ and Thiazole‐Containing Di‐ and Tripeptide Mimetics (1996)

An important step in the synthesis of heterocyclic amino acids such as 1, which can be used to modify and constrain peptide backbones, is the newly developed oxidation of dihydrooxazoles to give oxazoles with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)/CCl4/acetonitrile/pyridine.
A Novel Mutation within the Central<i>Listeria monocytogenes</i>Regulator PrfA That Results in Constitutive Expression of Virulence Gene Products (2004)

The PrfA protein of Listeria monocytogenes functions as a key regulatory factor for the coordinated expression of many virulence genes during bacterial infection of host cells. PrfA activity is controlled by multiple regulatory mechanisms, including an apparent requirement for either the presence of a cofactor or some form of posttranslational modification that regulates the activation of PrfA. In this study, we describe the identification and characterization of a novel PrfA mutation that results in constitutive activation of the PrfA protein. The PrfA L140F mutation was found to confer high-level expression of PrfA-regulated genes and to be functionally dominant over the wild-type allele. The presence of the PrfA L140F mutation resulted in the aggregation of L. monocytogenes in broth culture and, unlike previously described prfA mutations, appeared to be slightly toxic to the bacteria. High-level PrfA-dependent gene expression showed no additional increase in L. monocytogenes strains containing an additional copy of prfA L140F despite a >4-fold increase in PrfA protein levels. In contrast, the introduction of multiple copies of the wild-type prfA allele to L. monocytogenes resulted in a corresponding increase in PrfA-dependent gene expression, although overall expression levels remained far below those observed for PrfA L140F strains. These results suggest a hierarchy of PrfA regulation, such that the relative levels of PrfA protein present within the cell correlate with the levels of PrfA-dependent gene expression when the protein is not in its fully activated state; however, saturating levels of the protein are then quickly reached when PrfA is converted to its active form. Regulation of the PrfA activation status must be an important facet of L. monocytogenes survival, as mutations that result in constitutive PrfA activation may have deleterious consequences for bacterial physiology.
Catalyst-free two-step growth of quasialigned ZnMgO nanorods and their properties (2006)

Quasialigned ZnMgO ternary nanorods with sharp single-crystal tips were prepared by using thermal evaporation without a catalyst. The growth process included two steps: the formation of ZnO droplets and then the formation of ZnMgO nanorods. The obtained ZnMgO nanorods with abruptly sharpened tips crystallized well as hexagonal phase, with preferred orientation along the c axis. The nanorods are about 200nm in diameter and the tips are 50nm. With the Mg incorporation, the ultraviolet near-band-edge emission shows a clear blueshift. The possible growth mechanism of the ZnMgO nanorods is discussed.
Sex chromosomes and genetic association studies (2009)

Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex population studies, and as a result of X inactivation. This paper reviews recent developments in approaching these problems.
Slow phase of transvascular fluid flux reviewed (1990)

In six circuit experiments using a clinical hemofiltration device, we validated a colorimetric technique to measure transvascular volume exchange (VE). In 12 isolated excised canine left lower lobes, continuous colorimetric measurements of VE correlated well with calculations of VE from changes in microhematocrit obtained simultaneously. We introduced step increases in microvascular hydrostatic pressure (Pc) of 9 +/- 4.8 (SD) cmH2O and followed the time course of weight and continuous hematocrit changes measured colorimetrically for 40 min, after which Pc was returned to base line, while measurements were continuously obtained. This procedure was repeated for an additional 30 min. VE was calculated from the hematocrit signals and compared with the time course of the weight signal. After increases in Pc, followed by a rapid weight gain, weight signals followed a slow exponential time course, whereas the calculated VE changed linearly. VE reflected approximately 60% of the slow weight gain. When Pc was decreased, weight signals decreased exponentially, whereas VE continued to increase linearly at a slower rate. These results suggest that a significant component of the slow weight signal represents slow vascular volume changes. Contrary to what the weight signal suggested, edema was never reabsorbed over the range of Pc measured.
22.3: Viewing Angle‐Aware Color Correction for LCDs (2007)

Abstract Viewing angle‐dependent color shift is one of the major drawbacks of liquid crystal displays (LCD). As the viewing angle increases, not only the luminance but also the color saturation reduces and compromises the image quality. In this paper, we characterize the viewing angle‐dependent color shift of an LCD and propose a compensation method of adjusting the backlights and panel transmittance simultaneously. By increasing the panel transmittance, the color shift and luminance attenuation can be minimized. By increasing or decreasing the backlight intensity, the original luminance can be preserved or the power consumption can be reduced. Similar to previous approaches, the proposed method requires a video camera to capture the user's location for calculating the viewing angle. We have also implemented an emulator for reproducing the viewing angle‐dependent visual effects.
The efficiency of fatty acids, N-acetyl-D-mannosamine, and N-acetylneuraminic acid for a change in the sialylation profile of recombinant darbepoetin alfa in CHO cell culture (2015)

A combination of cultural medium and nourishment providing a high yield of target glycated forms of recombinant darbepoetin alfa produced by CHO cell culture was selected. The influence of different substances—precursors of glycans in glycosylation reactions—on the yield of highly sialylated forms of recombinant darbepoetin alfa was researched. It was shown that the use of 20 mM N-acetyl-D-mannosamine is the most effective for an increase in the concentration of highly sialylated forms of the protein in cultural fluid.
A novel method for the collimation of ions at atmospheric pressure (2006)

Measured gains in source-to-target ion transmission of well over two orders of magnitude are reported from the application of a robust and versatile electrostatic lens that requires no voltage supply and consumes negligible power. When exposed to an ion flux across a potential gradient, a series of electrically-floating circular conductors automatically attain a profile of convergent potentials. This passive ion lens is used to collimate atmospheric ion source currents that range from 30 pA to 7 nA, increasing the ion signal strength at the target by factors of 20–130 times that of the unaided signal.
Mannose-specific adherence of Escherichia coli freshly excreted in the urine of patients with urinary tract infections, and of isolates subcultured from the infected urine (1981)

The mannose-specific adherence to yeast cells of Escherichia coli excreted in the urine of patients with urinary tract infections was compared with that of isolates from the same urine after growth of the bacteria in broth. The results revealed that although E. coli excreted in only 2 of 24 urine specimens exhibited mannose-specific adherence, about half of the broth cultures from these specimens did so. Examination of representative specimens of E. coli excreted in urine showed that coating antibodies, mannose-containing glycoproteins, and encapsulation were not responsible for the lack of the mannose-specific adherence. Our results suggest that E. coli strains that are genetically capable of exhibiting mannose-specific adherence may, when growing in the bladder, be in a phase of growth which suppresses the phenotypic expression of this trait. Mannose-specific adherence is indicative of the presence on the bacterial surface of adhesions (lectins) that bind the organisms to mannose residues on both epithelial and phagocytic cells. We propose that whereas at the initial stages of infection the bacteria may benefit from their ability to bind to mannose residues on epithelial cells, loss of this ability at the later stages of the infection is also beneficial, since the bacteria can no longer adhere to mannose residues on phagocytes, and are thus resistant to nonimmune phagocytosis.
Thermal strain measurement by one-beam laser speckle interferometry (1980)

A method of one-beam laser speckle interferometry was applied to the measurement of transient thermal strain fields in an aluminum plate heated at a small region. A ruby pulse laser minimized the effect of thermal air turbulence on speckle correlation. High quality isothetic fringe patterns were obtained. The result compares well with available existing data.
Accurate forces in a local-orbital approach to the local-density approximation (1990)

We make use of the existing formalism for calculating atomic forces within the local-density approximation (LDA) to determine forces in an all-electron, local-orbital framework. The forces are calculated as the proper total-energy derivatives, including the necessary basis-set corrections. In our computational technique the LDA potential is evaluated exactly on a variationally determined integration mesh which allows all integrals relevant to the electronic-structure problem to be computed to any desired accuracy. We apply our technique to the molybdenum dimer, the ethylene molecule, and the NaCl monomer to demonstrate the high accuracy of the calculated forces. In addition, we investigate directly the effects of integration and self-consistency errors on the accuracy of the forces, and use the results of these tests to suggest strategies for the efficient use of force information in structural studies.
Nanotechnology in Cancer Drug Delivery and Selective Targeting (2014)

Nanoparticles are rapidly being developed and trialed to overcome several limitations of traditional drug delivery systems and are coming up as a distinct therapeutics for cancer treatment. Conventional chemotherapeutics possess some serious side effects including damage of the immune system and other organs with rapidly proliferating cells due to nonspecific targeting, lack of solubility, and inability to enter the core of the tumors resulting in impaired treatment with reduced dose and with low survival rate. Nanotechnology has provided the opportunity to get direct access of the cancerous cells selectively with increased drug localization and cellular uptake. Nanoparticles can be programmed for recognizing the cancerous cells and giving selective and accurate drug delivery avoiding interaction with the healthy cells. This review focuses on cell recognizing ability of nanoparticles by various strategies having unique identifying properties that distinguish them from previous anticancer therapies. It also discusses specific drug delivery by nanoparticles inside the cells illustrating many successful researches and how nanoparticles remove the side effects of conventional therapies with tailored cancer treatment.