gebhart/patrepeval huggingface dataset:
Slurry erosive wear study of d-gun sprayed coatings on SAE 431 (2013)

The main aim of the present work is is to investigate the slurry erosion behavior of Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> -40TiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> -13TiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ceramic coatings deposited using d-gun thermal spray process characteristics resulting in quality coating. Slurry erosion testing was performed using a pot-type slurry erosion tester to evaluate slurry erosion resistance of the coatings. Three parameters are considered for slurry erosion wear testing viz. Impingement angle, slurry concentration and type of coating used. Surface morphology was examined using SEM images. The erosion behavior and mechanism of material removal was studied and discussed based on microstructural examination. It was observed that Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> -13TiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ceramic coatings deposited on SAE 431 exhibits higher slurry erosion resistance under all testing conditions as compared to Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> -40TiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and uncoated substrate material.
A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy (2014)

Metabolic syndrome includes glucose intolerance and dyslipidemia, both of which are strong risk factors for developing diabetes and atherosclerotic cardiovascular diseases. Recently, multiple groups independently studied a previously uncharacterized gene, officially named C19orf80 (human) and Gm6484 (mouse), but more commonly known as RIFL, Angptl8, betatrophin and lipasin. Both exciting and conflicting results have been obtained, and significant controversy is ongoing. Accumulating evidence from genome wide association studies and mouse genetic studies convincingly shows that lipasin is involved in lipid regulation. However, the mechanism of action, the identity of transcription factors mediating its nutritional regulation, circulating levels, and relationship among lipasin, Angptl3 and Angptl4, remain elusive. Betatrophin represents a promising drug target for replenishing β-cell mass, but current results have not been conclusive regarding its potency and specificity. Here, we summarize the consensus and controversy regarding functions of lipasin/betatrophin based on currently available evidence.
DESIGN AND DEVELOPMENT OF AN AUTOMATED AND NONCONTACT SENSING SYSTEM FOR CONTINUOUS MONITORING OF PLANT HEALTH AND GROWTH (2001)

An automated system was designed and built to continuously monitor plant health and growth in a controlled environment using a distributed system approach for operational control and data collection. The computer-controlled system consisted of a motorized turntable to present the plants to the stationary sensors and reduce microclimate variability among the plants. Major sensing capabilities of the system included machine vision, infrared thermometry, time domain reflectometry, and micro-lysimeters. The system also maintained precise growth-medium moisture levels through a computer-controlled drip irrigation system. The system was capable of collecting required data continuously to monitor and to evaluate the plant health and growth.
Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement (1993)

Recent studies suggest a role for rapid induction of transcription factors in stimulus-induced neuronal plasticity in the mammalian brain. Synaptic activation of transcription factors has been analyzed in the hippocampus using the long-term potentiation or enhancement (LTP/LTE) paradigm. Using this approach, several studies have identified transcription factors that are induced in hippocampal granule cells by NMDA receptor-dependent mechanisms; however, the link between long-term plasticity and activation of these genes has been called into question by reports suggesting that the thresholds for LTE and gene activation differ. To address this issue, we have used a chronic in vivo recording technique to monitor mRNA responses of several transcription factor genes to two different patterns of LTE-inducing electrical stimulation of entorhinal cortical afferents to hippocampus. One pattern consisted of 10 repetitions of a 20 or 25 msec train of pulses at 400 Hz (80 or 100 pulses total). This "10-train" pattern has been used in previous studies of LTE and produces robust synaptic enhancement lasting at least 3 d (Barnes, 1979). The other stimulation pattern consisted of 50 repetitions of a 20 msec train delivered at 400 Hz (400 pulses total), which is similar to parameters used in other studies reporting induction of c-fos in association with LTE (Dragunow et al., 1989; Jeffery et al., 1990; Abraham et al., 1992). Our results indicate that expression of zif268, monitored by in situ hybridization and immunostaining, is strongly induced by the 10-train stimulus pattern to levels similar to those induced by seizure activity. JunB mRNA levels are also modestly increased by the 10-train stimulus pattern; however, increases in JunB immunostaining were not detected. Neither c-fos nor c-jun mRNA were detectably induced by this stimulus. In contrast, the 50-train stimulus pattern resulted in a robust induction of c-fos and c-jun mRNA, in addition to zif268 and junB. Transcription factor responses to either stimulus pattern were blocked by the noncompetitive NMDA receptor antagonist MK-801. Identical transcription factor responses were observed in adult (6-12-month-old) and aged (23-26-month-old) rats, suggesting that synaptic mechanisms involved in these responses are preserved in aged animals. Analysis of LTE following either the 10- or 50-train stimulus patterns revealed identical magnitudes of initial induction and decay kinetics (approximately 3 d) and indicates that the 10-train stimulus pattern is sufficient to produce maximal synaptic enhancement.(ABSTRACT TRUNCATED AT 400 WORDS)
Translational Medicine in Action: Anti-CD20 Therapy in Lymphoma (2014)

The introduction of rituximab for B cell lymphoma in the late 1990s inaugurated a new era of cancer therapy showcasing mAbs. mAbs are in principle an amalgamation of two characteristics of a perfect anticancer drug. First, rituximab is a therapy targeted to the tumor cell, but it carries fewer side effects than does chemotherapy. Second, with its ability to directly engage the host immune system, it could potentially elicit longer lasting anticancer immunity, although this remains to be proven. This review highlights the fundamental scientific discoveries that allowed the development of clinically successful anti-CD20 mAbs. Since the approval of rituximab, a considerable amount of work has been undertaken by different groups trying to understand the workings and limitations of anti-CD20s. All of these efforts will be critical in designing new mAbs to CD20 and other targets and, ultimately, of anticancer mAbs that will improve on, or even replace, chemotherapy.
Automation of a problem list using natural language processing (2005)

Abstract Background The medical problem list is an important part of the electronic medical record in development in our institution. To serve the functions it is designed for, the problem list has to be as accurate and timely as possible. However, the current problem list is usually incomplete and inaccurate, and is often totally unused. To alleviate this issue, we are building an environment where the problem list can be easily and effectively maintained. Methods For this project, 80 medical problems were selected for their frequency of use in our future clinical field of evaluation (cardiovascular). We have developed an Automated Problem List system composed of two main components: a background and a foreground application. The background application uses Natural Language Processing (NLP) to harvest potential problem list entries from the list of 80 targeted problems detected in the multiple free-text electronic documents available in our electronic medical record. These proposed medical problems drive the foreground application designed for management of the problem list. Within this application, the extracted problems are proposed to the physicians for addition to the official problem list. Results The set of 80 targeted medical problems selected for this project covered about 5% of all possible diagnoses coded in ICD-9-CM in our study population (cardiovascular adult inpatients), but about 64% of all instances of these coded diagnoses. The system contains algorithms to detect first document sections, then sentences within these sections, and finally potential problems within the sentences. The initial evaluation of the section and sentence detection algorithms demonstrated a sensitivity and positive predictive value of 100% when detecting sections, and a sensitivity of 89% and a positive predictive value of 94% when detecting sentences. Conclusion The global aim of our project is to automate the process of creating and maintaining a problem list for hospitalized patients and thereby help to guarantee the timeliness, accuracy and completeness of this information.
Optimized design and analysis of preclinical intervention studies in vivo (2016)

Recent reports have called into question the reproducibility, validity and translatability of the preclinical animal studies due to limitations in their experimental design and statistical analysis. To this end, we implemented a matching-based modelling approach for optimal intervention group allocation, randomization and power calculations, which takes full account of the complex animal characteristics at baseline prior to interventions. In prostate cancer xenograft studies, the method effectively normalized the confounding baseline variability, and resulted in animal allocations which were supported by RNA-seq profiling of the individual tumours. The matching information increased the statistical power to detect true treatment effects at smaller sample sizes in two castration-resistant prostate cancer models, thereby leading to saving of both animal lives and research costs. The novel modelling approach and its open-source and web-based software implementations enable the researchers to conduct adequately-powered and fully-blinded preclinical intervention studies, with the aim to accelerate the discovery of new therapeutic interventions.
Magnetic Properties of Fe-X-N (X=Zr, Hf, Nb, Ta) Films (1992)

Fe-X-N (X=Zr, Hf, Nb, Ta) ternary system films containing ultra-fine α-Fe crystal grains, and whose elements X have a strong affinity for nitrogen that may form amorphous phases, were prepared by sputtering. The dependence of the soft magnetic properties on the film composition was Then investigated. Good soft magnetic properties and high saturation flux density B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> were obtained in each system. In particular, the Fe-Zr-N and Fe-Hf-N systems had a wide soft magnetic range, and films at certain compositions in these systems exhibited zero magnetostriction and high B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> values of up to 16 kG.
Fabrication of a-Si:H Thin Film Transistors on 4-inch Glass Substrates by a Large Area Ion Doping Technique (1991)

We developed a large area ion doping apparatus with an rf ion source of 50 cm in diameter. Charge accumulation during ion doping was suppressed by using a double grid. We fabricated a-Si:H TFT's on a 4-inch glass substrate by using the doping apparatus. By optimizing the thickness of the passivation film of TFT's, a field effect mobility, threshold voltage and an ON/OFF current ratio of 0.6 cm 2 /V·s, 4.9 V and 10 7 , respectively, were obtained. We confirmed the uniformity of electrical properties for TFT's on 4-in. glass substrates to be about ±2%. These characteristics of TFT's are suitable for switching elements in a large area LCD.
A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate (2012)

Colorectal cancer (CRC) is a leading cause of preventable cancer deaths worldwide, with dietary factors being recognised as key risk modifiers. Foods containing dietary fibre are protective to a degree that the World Cancer Research Fund classifies the evidence supporting their consumption as ‘convincing’. The mechanisms by which fibre components protect against CRC remain poorly understood, especially their interactions with the gut microbiome. Fibre is a composite of indigestible plant polysaccharides and it is emerging that fermentable fibres, including resistant starch (RS), are particularly important. RS fermentation induces SCFA production, in particular, relatively high butyrate levels, and in vitro studies have shown that this acid has strong anti-tumorigenic properties. Butyrate inhibits proliferation and induces apoptosis of CRC cell lines at physiological concentrations. These effects are attributed to butyrate's ability to alter gene transcription by inhibiting histone deacetylase activity. However, the more recent discovery of G-protein coupled receptors that bind butyrate and other SCFA and data obtained from proteomic and genomic experiments suggest that alternative pathways are involved. Here, we review the mechanisms involved in butyrate-induced apoptosis in CRC cells and, additionally, the potential role this SCFA may play in mediating key processes in tumorigenesis including genomic instability, inflammation and cell energy metabolism. This discussion may help to inform the development of strategies to lower CRC risk at the individual and population levels.
Studies on Heterocyclic Primary Amines. lll : Synthesis of N-(5-aryl-1,3.4-oxadiazol-2-yl) Triphenyl lmidophosphoranes (1980)

Department of Chemistry, Faculty of Science and University College for Women, Ain-Shams University, Cairo, Egypt <em>Manuscript received 24 January 1980, revised 5 May 1980 accepted 7 August 1980</em> Studies on Heterocyclic Primary Amines. lll : Synthesis of N-(5-aryl-1,3.4-oxadiazol-2-yl) Triphenyl lmidophosphoranes
Molecular level study of hot water extracted green tea buried in soils - a proxy for labile soil organic matter (2020)

Understanding the composition of soil organic matter (SOM) is vital to our understanding of how soils form, evolve and respond to external stimuli. The shear complexity of SOM, an inseparable mixture of thousands of compounds hinders the determination of structure-function relationships required to explore these processes on a molecular level. Litter bags and soil hot water extracts (HWE) have frequently been used to study the transformation of labile SOM, however these are still too complex to examine beyond compound classes. In this work, a much simpler mixture, HWE buried green tea, was investigated by Nuclear Magnetic Resonance (NMR) spectroscopy and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS), as a proxy for labile SOM. Changes induced by the burial over 90 days in a grassland, woodland and two peatland sites, one damaged by drainage and one undergoing restoration by drain-blocking, were analysed. Major differences between the extracts were observed on the level of compound classes, molecular formulae and specific molecules. The causes of these differences are discussed with reference to abiotic and biotic processes. Despite the vastly different detection limits of NMR and MS, chemometric analysis of the data yielded identical separation of the samples. These findings provide a basis for the molecular level interrogation of labile SOM and C-cycling processes in soils.
Decision-Making and Planning Method for Autonomous Vehicles Based on Motivation and Risk Assessment (2021)

In order to improve the real-time and computational efficiency of autonomous vehicles’ decision-making process, this paper draws on the decision-making behavior of human drivers with the motivation as the core and proposes a decision-making and planning method based on motivation and risk assessment. On the one hand, it analyzes and determines the motivations that cause the driving state to change for decision-making and planning. On the other hand, on the basis of the lateral trajectory prediction of surrounding vehicles, the longitudinal trajectory propensity prediction of different drivers is added to construct a risk assessment model that can reflect risk of the future time domain. Based on this, the motivation-based decision method is mapped into the risk assessment model, and a cost function is established to decouple the path and speed, so that the geometry and speed can be flexibly adjusted according to environmental risks. The simulation results show that the proposed method can effectively make driving behavior decisions and plan the trajectory in real time according to the current environment, which can improve the computational efficiency of the decision-making process and guarantee the safety at the same time.
Variable-conductance, level-set curvature for image denoising (2002)

This paper describes a partial differential equation for denoising images. The proposed method is demonstrably superior to anisotropic diffusion (and its many variations) for denoising images that are approximately piecewise constant. The method relies on an equation that is the level-set equivalent of the anisotropic diffusion equation proposed by Perona and Malik (1990). This proposed equation has come up in the literature, but has failed to be fully utilized due to a lack of analysis and the need for a stable, accurate numerical implementation. Our analysis shows that the proposed method is more aggressive than anisotropic diffusion at enhancing and preserving edges, and is less sensitive to the edge contrast parameter. Empirical results confirm these advantages, and show that for certain classes of images, one should always prefer the proposed method over anisotropic diffusion.
Comparative Study of the Antihypertensive Activity of Marrubium Vulgare and of the Dihydropyridine Calcium Antagonist Amlodipine in Spontaneously Hypertensive Rat (2004)

Water extract of Marrubium vulgare is widely used as antihypertensive treatment in folk medicine. We have compared the effect of 10-week-long treatment with amlodipine or Marrubium water extract on systolic blood pressure (SBP), cardiovascular remodeling and vascular relaxation in spontaneously hypertensive rats (SHR). Both treatments produced similar decrease in SBP. Amlodipine treatment reduced left ventricle, aortic and mesenteric artery weight. Marrubium treatment had a significant antihypertrophic effect in aorta only. Relaxation to acetylcholine (ACh) of mesenteric artery was improved by Marrubium but not by amlodipine treatment. These results demonstrate that, in addition to its antihypertensive effect, Marrubium water extract improved the impaired endothelial function in SHR.
Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of<i>Eubacterium cellulosolvens</i> (2008)

Cellobiose 2-epimerase (CE; EC 5.1.3.11) is known to catalyze the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose in Ruminococcus albus cells. Here, we report a CE in a ruminal strain of Eubacterium cellulosolvens for the first time. The nucleotide sequence of the CE had an ORF of 1218 bp (405 amino acids; 46 963.3 Da). The CE from E. cellulosolvens showed 44-54% identity to N-acyl-D-glucosamine 2-epimerase-like hypothetical proteins in the genomes of Coprococcus eutactus, Faecalibacterium prausnitzii, Clostridium phytofermentans, Caldicellulosiruptor saccharolyticus, and Eubacterium siraeum. Surprisingly, it exhibited only 46% identity to a CE from R. albus. The recombinant enzyme expressed in Escherichia coli was purified by two-step chromatography. The purified enzyme had a molecular mass of 46.7 kDa and exhibited optimal activity at around 35 degrees C and pH 7.0-8.5. In addition to cello-oligosaccharides, it converted lactose to epilactose (4-O-beta-D-galactopyranosyl-D-mannose).
Simulink simulation of proportional navigation and command to line of sight missile guidance (1995)

Proportional Navigation and Command To Line Of Sight missile guidance are explored. A system flow graph is developed for each guidance technique. The block transfer functions are developed and a state space representation of the system is defined. The missile systems are then tested using one two-dimensional engagement and two three-dimensional engagement scenarios. The final three- dimensional scenario introduces measurement noise in order to evaluate the effect of noise on the guidance algorithms. The engagement results are then compared to analyze the miss distance of each type of missile guidance.
Direct benzylic metalation of a phenethylamine derivative: potassium as the key to both generation and stabilization of a “labile anion” (2012)

t-BuLi-t-BuOK selectively metalates the benzylic position of 2-phenylethyldimethylamine under mild conditions without occurrence of β-elimination in the resulting metalated species. Theoretical and structural studies indicate that potassium is crucial for both the lowering of the barrier of the initial deprotonation step and the stabilization of the labile anion.
Robust PID Steering Control in Parameter Space for Highly Automated Driving (2014)

This paper is on the design of a parameter space based robust PID steering controller. This controller is used for automated steering in automated path following of a midsized sedan. Linear and nonlinear models of this midsized sedan are presented in the paper. Experimental results are used to validate the longitudinal and lateral dynamic models of this vehicle. This paper is on automated steering control and concentrates on the lateral direction of motion. The linear model is used to design a PID steering controller in parameter space that satisfies <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>D</mml:mi></mml:mrow></mml:math>-stability. The PID steering controller that is designed is used in a simulation study to illustrate the effectiveness of the proposed method. Simulation results for a circular trajectory and for a curved trajectory are presented and discussed in detail. This study is part of a larger research effort aimed at implementing highly automated driving in a midsized sedan.
Room-temperature Si single-electron memory fabricated by nanoimprint lithography (2003)

We report the design, fabrication, and characterization of room-temperature Si single-electron memories using nanoimprint lithography (NIL). The devices consist of a narrow channel metal–oxide–semiconductor field-effect transistor and a sub-10-nm storage dot, which is located between the channel and the gate. The memories operate at room temperature by charging and discharging one electron in or out of the dot. The charge retention time is up to two days. NIL is shown to be tailored for nanodevice fabrication. By using NIL as a nanolithography tool, the single-electron memory is more feasible for mass production.