gebhart/patrepeval huggingface dataset:
<i>Q</i>-switched ruby laser alloying of Ohmic contacts on gallium arsenide epilayers (1978)

Ohmic contacts of AuGe have been produced on GaAs epilayers by laser alloying. The contacts possess morphological and electrical properties which are superior to those formed by conventional alloying.
Differences in substrate specificities between cysteine protease CPB isoforms of <i>Leishmania mexicana</i> are mediated by a few amino acid changes (2004)

The CPB genes of the protozoan parasite Leishmania mexicana encode stage-regulated cathepsin L-like cysteine proteases that are important virulence factors and are in a tandem array of 19 genes. In this study, we have compared the substrate preferences of two CPB isoforms, CPB2.8 and CPB3, and a H84Y mutant of the latter enzyme, to analyse the roles played by the few amino acid differences between the isoenzymes in determining substrate specificity. CPB3 differs from CPB2.8 at just three residues (N60D, D61N and D64S) in the mature domain. The H84Y mutation mimics an additional change present in another isoenzyme, CPB18. The active recombinant CPB isoenzymes and mutant were produced using Escherichia coli and the S1-S3 and S1'-S3' subsite specificities determined using a series of fluorogenic peptide derivatives in which substitutions were made on positions P3 to P3' by natural amino acids. Carboxydipeptidase activities of CPB3 and H84Y were also observed using the peptide Abz-FRAK(Dnp)-OH and some of its analogues. The kinetic parameters of hydrolysis by CPB3, H84Y and CPB2.8 of the synthetic substrates indicates that the specificity of S3 to S3' subsites is influenced greatly by the modifications at amino acids 60, 61, 64 and 84. Particularly noteworthy was the large preference for Pro in the P2' position for the hydrolytic activity of CPB3, which may be relevant to a role in the activation mechanism of the L. mexicana CPBs.
Comparison of native and nonnative speakers' perspective in animated text visualization tool (2015)

Media conversion technologies such as speech recognition and speech synthesis have gained a lot of attention in recent years. They are applied in various human communication tools through smart phones and personal computers such as in language learning system. However, the learner still have loss in naturalness pronunciation problem because of effects on mother tongue interference. Although the learner can realize that his/her speech is different from the trainer's, the learner still cannot detect or check the precise wrong part in their utterances speech. We indicate these differences by visualizing a learner's wrong and correct pronunciation with speech-to-animated text visualization tool. In this study, we focused on the media conversion process between speech prosodic information and animated text information by using AHP method as the mapping method. The pairwise comparison between both speech and text information were conducted and evaluated by Japanese native and nonnative speakers. Here, we investigated the comparison between native and nonnative speakers' perspective and determined the ideal matching elements between attributes of speech and text information.
Automatically extracting information needs from Ad Hoc clinical questions. (2008)

Automatically extracting information needs from ad hoc clinical questions is an important step towards medical question answering. In this work, we first explored supervised machine-learning approaches to automatically classify an ad hoc clinical question into general topics. We then evaluated different methods for automatically extracting keywords from an ad hoc clinical question. Our methods were evaluated on the 4,654 clinical questions maintained by the National Library of Medicine. Our best systems or methods showed F-score of 76% for the task of question-topic classification and an average F-score of 56% for extracting keywords from ad hoc clinical questions.
Anoxic induction of ATF-4 through HIF-1–independent pathways of protein stabilization in human cancer cells (2003)

Hypoxia is a key factor in tumor development, contributing to angiogenesis and radiotherapy resistance. Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor regulating the response of cancer cells to hypoxia. However, tumors also contain areas of more severe oxygen depletion, or anoxia. Mechanisms for survival under anoxia are HIF-1alpha independent in Caenorhabditis elegans and, thus, differ from the hypoxic response. Here we report a differential response of cancer cells to hypoxia and anoxia by demonstrating the induction of activating transcription factor-4 (ATF-4) and growth arrest DNA damage 153 (GADD153) protein specifically in anoxia and the lack of induction in hypoxia. By applying RNAi, ATF-4 induction in anoxia was shown to be independent of HIF-1alpha, and desferrioxamine mesylate (DFO) and cobalt chloride induced HIF-1alpha but not ATF-4 or GADD153. Furthermore, the inductive response of ATF-4 and GADD153 was not related to alterations in or arrest of mitochondrial respiration and was independent of von Hippel-Lindau (VHL) disease mutations. In reoxygenated anoxic cells, ATF-4 had a half-life of less than 5 minutes; adding the proteasome inhibitor to normoxic cells up-regulated ATF-4 protein. Extracts from primary human tumors demonstrated more ATF-4 expression in tumors near necrotic areas. Thus, this study demonstrates a novel HIF-1alpha-independent anoxic mechanism that regulates ATF-4 induction at the protein stability level in tumor cells.
Neurochemical alterations in schizophrenia affecting the putative receptor targets of atypical antipsychotics (1999)

What mechanisms make an antipsychotic atypical? A common view is that the different therapeutic and side-effect profile of atypical compared to typical antipsychotics is due to their high affinity for specific dopamine and/or 5-HT (serotonin) receptors. Dopamine D 4 and 5-HT 2a receptors are particularly implicated, though many others have been proposed as well, including dopamine D 1 and D 3 , 5-HT 1a , 5-HT 2c , 5-HT 6 , 5-HT 7 and α 2 adrenergic receptors (for review, see Deutch et al, 1991; Ashby & Wang, 1996; Kinon & Lieberman, 1996).
A model for predicting the power delay profile characteristics inside a room (1999)

Multipath effects in indoor wireless communication systems exhibit a characteristic power delay profile (PDP) and can be a detriment to the system's performance. We present a simplified model for calculating the decay rate of the PDP for propagation within rooms. This simplified model provides a time-efficient means of predicting system performance. Predictions of this in-room PDP model are compared to results obtained from a finite-difference time-domain (FDTD) model. Additionally, comparisons of the IPDP model to measured data are presented. The RMS delay spread is the second central moment of the PDP of a propagation channel and is a measure of the communication link degradation due to multipath. We also show results of the estimated RMS delay spread from this model and show comparisons to the measured data. This IPDP model can be used to investigate the effects of variable room size and properties of the surfaces (or walls) on the decay characteristics of the PDP.
Indexing and Retrieval of Historical Aggregate Information about Moving Objects (2002)

Spatio-temporal databases store information about the positions of individual objects over time. In many applications however, such as traffic supervision or mobile communication systems, only summarized data, like the average number of cars in an area for a specific period, or phones serviced by a cell each day, is required. Although this information can be obtained from operational databases, its computation is expensive, rendering online processing inapplicable. A vital solution is the construction of a spatiotemporal data warehouse. In this paper, we describe a framework for supporting OLAP operations over spatiotemporal data. We argue that the spatial and temporal dimensions should be modeled as a combined dimension on the data cube and present data structures, which integrate spatiotemporal indexing with pre-aggregation. While the well-known materialization techniques require a-priori knowledge of the grouping hierarchy, we develop methods that utilize the proposed structures for efficient execution of ad-hoc group-bys. Our techniques can be used for both static and dynamic dimensions. 1
Catching protein antigens by antibody affinity electrophoresis (2004)

A new kind of affinity electrophoresis called antibody affinity electrophoresis is a technique used to capture protein antigens based on their interactions with specific monoclonal or polyclonal antibodies incorporated in the polyacrylamide gel. Polyclonal anti-glutathione-S-transferase (anti-GST), monoclonal anti-bovine serum albumin (anti-BSA), and polyclonal anti-human alpha-lactalbumin are embedded in distinct areas of a 7.5% native polyacrylamide gel. Some of the embedded antibodies get covalently and/or noncovalently incorporated into the gel matrix network. Under electrophoresis conditions, these antibodies do not show significant electrophoretic mobility, as compared to their specific protein antigen analytes. We observed that electrophoretic migration of GST, BSA, and protein G ceases when they encounter anti-GST, anti-BSA, and immunoglobulin G, respectively.
Genes for Small, Noncoding RNAs under Sporulation Control in <i>Bacillus subtilis</i> (2005)

The process of sporulation in the bacterium Bacillus subtilis is known to involve the programmed activation of several hundred protein-coding genes. Here we report the discovery of previously unrecognized genes under sporulation control that specify small, non-protein-coding RNAs (sRNAs). Genes for sRNAs were identified by transcriptional profiling with a microarray bearing probes for intergenic regions in the genome and by use of a comparative genomics algorithm that predicts regions of conserved RNA secondary structure. The gene for one such sRNA, SurA, which is located in the region between yndK and yndL, was induced at the start of development under the indirect control of the master regulator for entry into sporulation, Spo0A. The gene for a second sRNA, SurC, located in the region between dnaJ and dnaK, was switched on at a late stage of sporulation by the RNA polymerase sigma factor sigmaK, which directs gene transcription in the mother cell compartment of the developing sporangium. Finally, a third intergenic region, that between polC and ylxS, which specified several sRNAs, including two transcripts produced under the control of the forespore-specific sigma factor sigmaG and a third transcript generated by sigmaK, was identified. Our results indicate that the full repertoire of sporulation-specific gene expression involves the activation of multiple genes for small, noncoding RNAs.
Mucosal Administration of CpG Oligodeoxynucleotide Elicits Strong CC and CXC Chemokine Responses in the Vagina and Serves as a Potent Th1-Tilting Adjuvant for Recombinant gD2 Protein Vaccination against Genital Herpes (2006)

Although sexually transmitted pathogens are capable of inducing pathogen-specific immune responses, vaginal administration of nonreplicating antigens elicits only weak, nondisseminating immune responses. The present study was undertaken to examine the potential of CpG-containing oligodeoxynucleotide (CpG ODN) for induction of chemokine responses in the genital tract mucosa and also as a vaginal adjuvant in combination with glycoprotein D of herpes simplex virus type 2 (HSV-2) for induction of antigen-specific immune responses. We found that a single intravaginal administration of CpG ODN in mice stimulates a rapid and potent response of CC chemokines macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and RANTES as well as of CXC chemokines MIP-2 and IP-10 in the vagina and/or the genital lymph nodes. Importantly, intravaginal vaccination with recombinant gD2 in combination with CpG ODN gave rise to a strong antigen-specific Th1-like immune response in the genital lymph nodes as well as the spleens of the vaccinated mice. Further, such an immunization scheme conferred both systemic and mucosal immunoglobulin G antibody responses as well as protection against an otherwise lethal vaginal challenge with HSV-2. These results illustrate the potential of CpG ODN for induction of potent chemokine responses in the genital tract and also as a vaginal adjuvant for generation of Th1-type mucosal and systemic immune responses towards a nonreplicating antigen derived from a sexually transmitted pathogen. These data have implications for the development of a mucosal vaccine against genital herpes and possibly other sexually transmitted diseases.
Characterization of repetitive DNA in the Mycoplasma genitalium genome: possible role in the generation of antigenic variation. (1995)

We have characterized a family of repetitive DNA elements with homology to the MgPa cellular adhesion operon of Mycoplasma genitalium, a bacterium that has the smallest known genome of any free-living organism. One element, 2272 bp in length and flanked by DNA with no homology to MgPa, was completely sequenced. At least four others were partially sequenced. The complete element is a composite of six regions. Five of these regions show sequence similarity with nonadjacent segments of genes of the MgPa operon. The sixth region, located near the center of the element, is an A+T-rich sequence that has only been found in this repeat family. Open reading frames are present within the five individual regions showing sequence homology to MgPa and the adjacent open reading frame 3 (ORF3) gene. However, termination codons are found between adjacent regions of homology to the MgPa operon and in the A+T-rich sequence. Thus, these repetitive elements do not appear to be directly expressible protein coding sequences. The sequence of one region from five different repetitive elements was compared with the homologous region of the MgPa gene from the type strain G37 and four newly isolated M. genitalium strains. Recombination between repetitive elements of strain G37 and the MgPa operon can explain the majority of polymorphisms within our partial sequences of the MgPa genes of the new isolates. Therefore, we propose that the repetitive elements of M. genitalium provide a reservoir of sequence that contributes to antigenic variation in proteins of the MgPa cellular adhesion operon.
ひと目でわかるMicrosoft Office 2004 for Mac (2004)

Ｏｆｆｉｃｅ ２００４の基本操作 Ｏｆｆｉｃｅ ２００４の応用操作 Ｗｏｒｄ ２００４の基本操作 Ｗｏｒｄ ２００４の応用操作 Ｅｘｃｅｌ ２００４の基本操作 Ｅｘｃｅｌ ２００４の応用操作 ＰｏｗｅｒＰｏｉｎｔ ２００４の基本操作 ＰｏｗｅｒＰｏｉｎｔ ２００４の応用操作 Ｅｎｔｏｕｒａｇｅ ２００４の基本操作 Ｅｎｔｏｕｒａｇｅ ２００４の応用操作 プロジェクトセンターの利用 ＭＳＮ Ｍｅｓｓｅｎｇｅｒの操作 Ｗｅｂ機能とデータ連携
Factors controlling the photoresponse of copper(<scp>i</scp>) diimine dyes containing hole-transporting dendrons in dye-sensitized solar cells: substituent and solvent effects (2014)

A detailed study of how two factors (substituents on ancillary ligands and solvents during dye assembly) affect performances of copper(<sc>i</sc>) diimine dyes in DSCs with phosphonic acid anchoring groups is presented.
Classifying disease outbreak reports using n-grams and semantic features (2008)

This paper explores the benefits of using n-grams and semantic features for the clas-sification of disease outbreak reports, in the context of a text mining system — BioCaster — that identifies and tracks emerging infectious disease outbreaks from online news. We show that a combination of bag-of-words features, n-grams and se-mantic features, in conjunction with feature selection, improves classification accuracy at a statistically significant level when com-pared to previous work. A novel feature of the work reported in this paper is the use of a semantic tagger — the USAS tagger — to generate features. 1
Preclinical, pharmacologic, and phase I studies of gemcitabine. (1997)

Gemcitabine (2',2'-difluorodeoxycytidine) is a novel nucleoside analogue that exerts its antitumor activity via multiple mechanisms of action. These include (1) incorporation of gemcitabine into replicating DNA, which inhibits DNA replication and cell growth, (2) masked DNA chain termination, and (3) several self-potentiation mechanisms that serve to increase intracellular levels of the active compound. Preclinical experiments in various cell lines and animal models demonstrate a broad range of cytotoxic activity. Pharmacokinetic studies of gemcitabine delivered by its usual schedule (30-minute weekly infusion) reveal a short plasma half-life and a high clearance into central and peripheral compartments (two-compartment model). The drug is excreted almost completely in the urine as the parent compound and primary metabolite (difluorodeoxyuridine). Phase I trials demonstrate that pharmacokinetics are schedule dependent and that, in general, gemcitabine is well tolerated. Dose-limiting toxicities are primarily myelosuppression, with other toxicities being rash, flu-like symptoms, and transient elevations in liver function tests.
Interplay of Orbital Tuning and Linker Location in Controlling Electronic Communication in Porphyrin Arrays (1999)

The β-diphenylethyne-linked porphyrin dimers ZnFbU-β (nonlinking meso-mesityl substituents) and F30ZnFbU-β (nonlinking meso-pentafluorophenyl substituents) and their bis-Zn analogues have been examined by static spectroscopic (absorption, fluorescence, electron paramagnetic resonance), time-resolved spectroscopic (absorption, fluorescence), and electrochemical (cyclic and square-wave voltammetry, coulometry) methods. The β-linked dimers were examined to test the hypothesis that the nature of the porphyrin HOMO (a1u versus a2u) in concert with the position of the linker (β-pyrrole or meso carbon) mediates electronic communication (excited-state energy transfer, ground-state hole-hopping). The major findings are as follows: (1) The rate of energy transfer is (56 ps)-1 for ZnFbU-β and (24 ps)-1 for F30ZnFbU-β. (2) The rate of hole/electron hopping in the monooxidized bis-Zn complex [F30Zn2U-β]+ is in the fast-exchange limit and is at least comparable to that for [Zn2U-β]+. These findings indicate that the presence of pentafluorophenyl groups causes enhancement of electronic communication in the β-linked dimers but attenuation in the meso-linked dimers. These opposite effects in the β- versus meso-linked dimers are explained by the fact that both pentafluorophenyl-substituted dimers have a1u HOMOs, which exhibit significant β-pyrrole electron density, whereas both mesityl-substituted dimers have a2u HOMOs, which exhibit large meso-carbon density. Thus, the combination of an a1u HOMO with a β-linker or an a2u HOMO with a meso linker results in optimal electronic communication. Collectively, these results demonstrate that the nature of the frontier orbitals and position of connection of a covalent linker (in addition to distance, orientation, and energetics) must be considered in the design architecture of molecular photonic devices.
Effects of Fluvastatin and Bezafibrate Combination on Plasma Fibrinogen, t-plasminogen Activator Inhibitor and C Reactive Protein Levels in Coronary Artery Disease Patients with Mixed Hyperlipidaemia (FACT Study) (2000)

The combined effects on fibrinogen and plasma lipids achieved by fluvastatin and bezafibrate combination treatment might be more useful than the simple reduction of cholesterol in preventing ischaemic cardiovascular disease.
The Nuclear Cap-binding Complex Is a Novel Target of Growth Factor Receptor-coupled Signal Transduction (1999)

In an attempt to further understand how nuclear events (such as gene expression, nuclear import/export, and cell cycle checkpoint control) might be subject to regulation by extracellular stimuli, we sought to identify nuclear activities under growth factor control. Using a sensitive photoaffinity labeling assay that measured [alpha-32P]GTP incorporation into nuclear proteins, we identified the 20-kDa subunit of the nuclear cap-binding complex (CBC) as a protein whose binding activity is greatly enhanced by the extracellular stimulation of serum-arrested cells. The CBC represents a 20- and 80-kDa heterodimer (the subunits independently referred to as CBP20 and CBP80, respectively) that binds the 7-methylguanosine cap on RNAs transcribed by RNA polymerase II. This binding facilitates precursor messenger RNA splicing and export. We have demonstrated that the [alpha-32P]GTP incorporation into CBP20 was correlated with an increased ability of the CBC to bind capped RNA and have used the [alpha-32P]GTP photoaffinity assay to characterize the activation of the CBC in response to growth factors. We show that the CBC is activated by heregulin in HeLa cells and by nerve growth factor in PC12 cells as well as during the G1/S phase of the cell cycle and when cells are stressed with UV irradiation. Additionally, we show that cap-dependent splicing of precursor mRNA, a functional outcome of CBC activation, can be catalyzed by growth factor addition to serum-arrested cells. Taken together, these data identify the CBC as a nuclear target for growth factor-coupled signal transduction and suggest novel mechanisms by which growth factors can influence gene expression and cell growth.
Data mining for gaze tracking system (2008)

An eye tracking system has been developed to control a computer cursor by tracking the userpsilas gaze. This tracking is achieved via a small form factor camera mounted near the userpsilas eye, which communicates image data to a computer system. The computer system processes the image and determines the direction of the userpsilas gaze. This position data is used to move a cursor on a display. By using this as an input method, the system allows full hands-free use of the computer. Additionally, an augmented reality system has been created using a head mounted micro display. This creates a heads-up display for the user.
Sequence of the cDNA for the human fibroblast type interleukin-1 receptor (1989)

Journal Article Sequence of the cDNA for the human fibroblast type interleukin-1 receptor Get access Anne O. Chua, Anne O. Chua Department of Molecular Genetics, Hoffmann-La Roche Inc.Nutley, NJ 07110, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Ueli Gubler Ueli Gubler Department of Molecular Genetics, Hoffmann-La Roche Inc.Nutley, NJ 07110, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 17, Issue 23, 11 December 1989, Page 10114, https://doi.org/10.1093/nar/17.23.10114 Published: 11 December 1989 Article history Accepted: 20 October 1989 Published: 11 December 1989
Influência da idade da planta na indução floral sobre a produção do abacaxizeiro (1983)

Em experimento instalado em solo tipo Regossolo em Quicama, RI, estudou-se a influencia da aplicacao de carbureto de calcio em plantas de abacaxi da cultivar Smooth Cayenne com sete, oito, nove e dez meses de idade, utilizando-se o delineamento estatistico de blocos ao acaso e quatro repeticoes. Foram constatadas diferencas estatisticamente significativas entre os tratamentos para peso e comprimento dos frutos. As plantas induzidas aos sete meses produziram frutos mais leves quando comparadas as nao-induzidas. As induzidas aos sete, oito e nove meses apos o plantio produziram frutos menores, comparados aos obtidos sem inducao artificial da floracao. Nao foi encontrada diferenca significativa para acidez total.