gebhart/patrepeval huggingface dataset:
Reversal of apparent AIDS dementia complex following treatment with vitamin B<sub>12</sub> (1993)

The human immunodeficiency virus (HIV)-associated dementia complex is characterized by difficulties in concentration and memory followed by apathy, social withdrawal and motor dysfunction. Decreased serum vitamin B12 levels occur in up to 20% of patients with acquired immune deficiency syndrome (AIDS) and may adversely contribute to the haematologic and neurologic dysfunction which is frequently attributed to the human immunodeficiency virus. We describe a patient with AIDS who presented with an apparent advanced AIDS dementia complex. There was an associated low serum vitamin B12 resulting from malabsorption due to low gastric intrinsic factor secretion. Following treatment with vitamin B12 the symptoms resolved over a 2-month period. We believe that the AIDS dementia complex represented a reversible adverse synergistic interaction between the human immunodeficiency virus and vitamin B12 deficiency.
Super-High-Frequency Band Filters Configured with Air-Gap-Type Thin-Film Bulk Acoustic Resonators (2010)

The first 24 and 30 GHz band thin-film bulk acoustic resonator (FBAR) filters are reported in this paper. The filters were configured with air-gap-type FBARs on a flat silicon substrate. They were designed using a Butterworth–Van-Dyke (BVD) equivalent circuit considering the linear relationship between resonant frequency, capacitance ratio, and loss in the FBAR. The measured characteristics corresponded with those of the simulation using the equivalent circuit in the pass-band. The center frequency, fractional bandwidth, minimum insertion loss, and out-of-band suppression were 23.8 GHz, 3.4%, -3.8 dB, and -13 dB in the 24 GHz band filter, and 29.2 GHz, 3.4%, -3.8 dB, and -11 dB in the 30 GHz band filter, respectively.
Regulation of programmed cell death following T cell activation in vivo. (1998)

Activation of T cell hybridomas in vitro induces rapid Fas-Fas ligand (FasL)-mediated programmed cell death (apoptosis). In contrast, T cells activated by antigen or superantigen in vivo undergo a population expansion and then decline due to Fas-FasL-mediated activation-induced apoptosis (AIA). We asked how T cells activated by antigen in vivo proliferated before undergoing apoptosis. Two possibilities were analyzed: either (i) the apoptosis program was not 'turned on' or (ii) was 'blocked' during the period of cellular proliferation in vivo. Data presented in this manuscript support the second of these possibilities. CD4+ T cells activated in vivo were resistant to anti-fas-mediated apoptosis until 48 h following staphylococcal enterotoxin B (SEB) administration, despite the fact that activated proliferating T cells expressed high levels of Fas (CD95) antigen and many 'apoptosis genes' were induced within 24 h of SEB administration. The analysis of the expression patterns of 'apoptosis genes' during the T cell activation further suggested that temporal blockade of AIA may be due to the induction of apoptosis-preventing genes, such as bag-1.
Slowing Down the Ras Lane: miRNAs as Tumor Suppressors? (2005)

MicroRNAs (miRNAs) are small noncoding transcripts that regulate gene expression by promoting the degradation of transcribed messages or by inhibiting translation. Although bioinformatic approaches suggest that miRNAs may regulate the expression of a large fraction of the genome, the determination of miRNA gene targets and biological functions has been comparatively limited. Emerging studies suggest that many miRNAs may participate in human disease, including oncogenesis; but for the most part, the observations have been correlative. A recent study by Johnson and colleagues indicates that the let-7 miRNA negatively regulates the oncogenic family of Ras guanosine triphosphatases in both Caenorhabditis elegans and human tumor cell lines, suggesting that let-7 may act as a tumor suppressor. This work raises several important questions: Can other miRNAs act as tumor suppressors or oncogenes? Is miRNA deregulation a critical aspect of tumor development and maintenance? A number of recent studies have begun to address some of these functional questions, providing the field with a greater understanding of the role of miRNAs in cancer.
An Anti‐Chitinase Malaria Transmission–Blocking Single‐Chain Antibody as an Effector Molecule for Creating a<i>Plasmodium falciparum–</i>Refractory Mosquito (2005)

Indirect evidence has suggested the existence of a second chitinase gene, PgCHT2, in the avian malaria parasite Plasmodium gallinaceum. We have now identified PgCHT2 as the orthologue of the P. falciparum chitinase gene PfCHT1, a malaria transmission-blocking target. Computational phylogenetic evidence and biochemical and cell biological functional data support the hypothesis that an avian-related Plasmodium species was the ancestor of both P. falciparum and P. reichenowi, and this single lineage gave rise to another lineage of malaria parasites, including P. vivax, P. knowlesi, P. berghei, P. yoelii, and P. chabaudi. A recombinant PfCHT1/PgCHT2-neutralizing single-chain antibody significantly reduced P. falciparum and P. gallinaceum parasite transmission to mosquitoes. This single-chain antibody is the first anti-P. falciparum effector molecule to be validated for making a malaria transmission-refractory transgenic Anopheles species mosquito. P. gallinaceum is a relevant animal model that facilitates a mechanistic understanding of P. falciparum invasion of the mosquito midgut.
Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte [Review] (2013)

Experimental transplantation of endocrine tissues has led to significant advances in our understanding of endocrinology and metabolism. Endocrine cell transplantation therapy is expected to be applied to the treatment of metabolic endocriopathies. Restoration of functional pancreatic beta-cell mass or of functional adipose mass are reasonable treatment approaches for patients with diabetes or lipodystrophy, respectively. Human induced pluripotent stem (iPS) cell research is having a great impact on life sciences. Doctors Takahashi and Yamanaka discovered that the forced expression of a set of genes can convert mouse and human somatic cells into a pluripotent state [1, 2]. These iPS cells can differentiate into a variety of cell types. Therefore, iPS cells from patients may be a potential cell source for autologous cell replacement therapy. This review briefly summarizes the current knowledge about transplantation therapy for diabetes mellitus, the development of the endocrine pancreas and adipocytes, and endocrine-metabolic disease-specific iPS cells.
The Dimensional Stability of Carpets in Installations (1978)

Dimensional stability of floor coverings to.forces encountered under end-use conditions has not been investigated extensively, although problems of wrinkling and puckering of carpets in stretch installations arise frequently. Changes in ambient humidity occur over broad ranges in most buildings; consequently, carpets which are not stable to changes in ambient humidity may be susceptible to puckering. A test procedure based on a method adopted by the British Standards Institution was used to characterize a large number of carpets for dimensional stability to changes in ambient humidity. Several carpet construction characteristics—total weight, pile yarn type, gage, and stitch density—were found to have little relationship to stability to humidity change. Large differences in stability were observed among manufacturers. Tufted carpets having jute backings were found to be less stable than carpets manufactured with synthetic backings.
An EM algorithm for video summarization, generative model approach (2002)

In this paper, we address the visual video summarization problem in a Bayesian framework in order to detect and describe the underlying temporal transformation symmetries in a video sequence. Given a set of time correlated frames, we attempt to extract a reduced number of image-like data structures which are semantically meaningful and that have the ability of representing the sequence evolution. To this end, we present a generative model which involves jointly the representation and the evolution of appearance. Applying Linear Dynamical System theory to this problem, we discuss how the temporal information is encoded yielding a manner of grouping the iconic representations of the video sequence in terms of invariance. The formulation of this problem is driven in terms of a probabilistic approach, which affords a measure of perceptual similarity taking both learned appearance and time evolution models into account.
Design of a Wide Bandwidth Phase Modulator and Modeling of Polar Transmitters with Split-band Envelope Modulation (2013)

High bandwidth and spectral efficiency requirements in today's wireless communication systems require innovative architectures to maintain high transmitter efficiency. Polar transmitters with a high efficiency switching power amplifier offer a promising solution to this problem. Such architectures require phase and envelope modulators with wider bandwidths than their Cartesian counterparts. This work presents a open loop phase modulator with 12 physical bits which is designed to operate at a carrier frequency of 1.25GHz with a phase bandwidth of up to 125MHz. The system was implemented in 65nm commercial CMOS process and a prototype IC achieved 8-bit linearity with pre-distortion and was modulated with PSK signals at 20.83MS/s while consuming 27mW of power. Separately, the problem of envelope modulation with a split-band envelope modulated system is considered. A MATLAB/Simulink model was developed to analyze trade-offs between efficiency, dynamic range and error in such a system.
Hematopoietic Growth Factors in Oncology (2004)

The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication.
Energy Autonomous UWB Localization (2017)

In the new scenarios foreseen by the Internet of Things (IoT), industrial and consumer systems will be required to detect and localize tagged items with high accuracy using cheap, energy autonomous, and disposable tags. This paper discusses system-level and circuit-level aspects to be adopted for future generation passive radio-frequency identification (RFID) tags with localization capabilities. It is argued that RFID-enabled localization strategies, combining ultra-wideband (UWB) backscattering for communication/localization purposes and UHF for “on demand” powering of battery-less tags can be successfully exploited to this purpose. The proposed architecture adopts a small number of reference nodes, acting both as UWB readers and as UHF power sources. Architectural and circuital considerations on different design choices for the UWB-RFID tag are discussed, focusing on available off-the-shelf components. Power budget constraints for UWB backscattering operation and UHF wireless powering are derived in worst-case conditions. Furthermore, the simulation results, verified with experiments, prove the feasibility of cm-level localization accuracy at distances of several meters even in indoor scenarios where multi-path fading might be present.
An architecture for intelligent resource agents (2002)

The paper describes an intelligent resource agent architecture comprising several classes of mediating agents, which interact cooperatively in a distributed environment to enable appropriate, timely, customized access to Internet resources. These agents communicate with each other in terms of a shared set of object definitions, encoded in a common message syntax. Messages are transmitted via the Knowledge Query Manipulation Language (KQML), an emerging standard agent communication language. This architecture has been demonstrated in the domain of K-12 education, to support remote resource utilization and collaboration in the classroom within a WWW infrastructure.
Enhanced Supercapacitive Performance of Chemically Grown Cobalt–Nickel Hydroxides on Three-Dimensional Graphene Foam Electrodes (2014)

Chemical growth of mixed cobalt-nickel hydroxides (CoxNi1-x(OH)2), decorated on graphene foam (GF) with desirable three-dimensional (3D) interconnected porous structure as electrode and its potential energy storage application is discussed. The nanostructured CoxNi1-x(OH)2 films with different Ni:Co (x) compositions on GF are prepared by using the chemical bath deposition (CBD) method. The structural studies (X-ray diffraction and X-ray photoelectron spectroscopy) of electrodes confirm crystalline nature of CoxNi1-x(OH)2/GF and crystal structure consists of Ni(OH)2 and Co(OH)2. The morphological properties reveal that nanorods of Co(OH)2 reduce in size with increases in nickel content and are converted into Ni(OH)2 nanoparticles. The electrochemical performance reveals that the Co0.66Ni0.33(OH)2/GF electrode has maximum specific capacitance of ∼1847 F g(-1) in 1 M KOH within a potential window 0 to 0.5 V vs Ag/AgCl at a discharge current density of 5 A g(-1). The superior pseudoelectrochemical properties of cobalt and nickel are combined and synergistically reinforced with high surface area offered by a conducting, porous 3D graphene framework, which stimulates effective utilization of redox characteristics and communally improves electrochemical performance with charge transport and storage.
Group-velocity-matched second-harmonic generation: An efficient scheme for femtosecond ultraviolet pulse generation in periodically domain-inverted β-BaB2O4 (1993)

With the combined use of the group-velocity-matched and the quasi-phase-matched frequency doubling in β-BaB2O4, femtosecond ultraviolet pulse generation is found to be realizable with high efficiency. Calculation of the group-velocity mismatch shows that at ∼630 nm wavelength of the pump pulse the mismatch vanishes completely. Typical design parameters such as the walk-off length, the dispersion lengths, and the quasi-phase-matching period are evaluated numerically around the zero walk-off wavelength. Temperature tuning of the operation wavelength is investigated as well.
Enhancement of fluorescence signal with one dimensional photonic band gap structure (2007)

In this paper, we propose to use one dimensional (1D) photonic band gap (PBG) structure to enhance the florescence excitation and collection for single molecule level imaging and sensing applications. In the setup, the incidence of excitation and the collection of the florescence are located on separate sides of the 1D PBG structure. The 1D PBG structure creates total internal reflection for the excitation wavelength. With carefully chosen 1D PBG structures, an enhanced evanescent field for the excitation wavelength at the interface between the last layer of the PBG and sample can be obtained. Meanwhile, the 1D PBG structure is designed such that it also serves as an omnidirectional reflector for the florescence signal, leading to higher collection efficiency. The combination of stronger excitation field and improved detection efficiency gives rise to two orders of magnitude enhancement of florescence signal.
Study of the influence of goal alignment on multi-organizational projects: A system dynamics approach (2013)

Scope and Method of Study: The purpose of this study is to examine how the level of goal alignment among the participant organizations in a multi-organizational project influences project dynamics and performance. Two projects cases were used in the study. Two system dynamics models were developed based on cases' data and previously validated projects system dynamics models. The first model aims to represent how the level of goal alignment affects project dynamics when a project team constituted by representatives of the different participating organizations executes the project. The second model aims to represent the case when the project team manages the project, which is executed by a third party. An assessment of the models' validity was performed by participants in the projects studied. An assessment of the possible use of the models in other contexts was performed through questionnaires completed by a panel of experts, and by comparison of the models' structures to previous research findings in related areas. Simulation experiments were performed to examine to what extent the models outputs represent plausible projects system behaviors according to the cases' data, and to explore the effects of possible moderating factors.
Giant magnetoelectric coefficients in (Fe90Co10)78Si12B10-AlN thin film composites (2010)

Thin film magnetoelectric (ME) two–two composites consisting of AlN and amorphous (Fe90Co10)78Si12B10 layers were fabricated by magnetron sputtering on Si (100) substrates. Upon magnetic field annealing they show an extremely high ME coefficient of 737 V/cm Oe at mechanical resonance at 753 Hz and 3.1 V/cm Oe out of resonance at 100 Hz. These are the highest reported ME coefficients in thin film composites ever. Furthermore, the induced magnetic anisotropy by field annealing serves the possibility to obtain a sensor element with a pronounced sensitivity in only one dimension, which allows the realization of a three-dimensional vector field sensor.
Laparoscopic or Lichtenstein repair for recurrent inguinal hernia: one unit's experience. (1999)

Surgical treatment of recurrent inguinal hernia is controversial. This is a prospective study of 50 patients who had laparoscopic total extraperitoneal repair (n = 25) or Lichtenstein repair (n = 25) for recurrent inguinal hernia. The two groups of patients were comparable in age, sex and type of hernia. Post-operatively, a seroma or a wound haematoma developed in 12 patients after Lichtenstein repair and in 4 patients after laparoscopic repair (p < 0.05). On average, analgesia was taken for 6.4 days after Lichtenstein repair compared with 3.4 days after laparoscopic repair (p < 0.05). In our unit, laparoscopic repair was associated with fewer complications and a significantly shorter duration of post-operative analgesia than Lichtenstein repair for recurrent inguinal hernia.
Living Polymers by the Use of Trithiocarbonates as Reversible Addition−Fragmentation Chain Transfer (RAFT) Agents:  ABA Triblock Copolymers by Radical Polymerization in Two Steps (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTLiving Polymers by the Use of Trithiocarbonates as Reversible Addition−Fragmentation Chain Transfer (RAFT) Agents: ABA Triblock Copolymers by Radical Polymerization in Two StepsRoshan T. A. Mayadunne, Ezio Rizzardo, John Chiefari, Julia Krstina, Graeme Moad, Almar Postma, and San H. ThangView Author Information CSIRO Molecular Science, Bag 10, Clayton South, Victoria 3169, Australia Cite this: Macromolecules 2000, 33, 2, 243–245Publication Date (Web):January 6, 2000Publication History Received23 August 1999Revised1 November 1999Published online6 January 2000Published inissue 1 January 2000https://pubs.acs.org/doi/10.1021/ma991451ahttps://doi.org/10.1021/ma991451arapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views8806Altmetric-Citations433LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Monomers,Organic compounds,Physical and chemical properties,Polymers,RAFT polymerization Get e-Alerts
In the Mouse, the Activation of the Hypothalamic Pituitary-Adrenal Axis by a Lipopolysaccharide (Endotoxin) Is Mediated through Interleukin-1* (1989)

The mechanisms through which endotoxin stimulates the hypothalamic-pituitary-adrenal axis are not well understood. In the studies reported here we tested the hypothesis that endotoxin increases plasma ACTH levels by releasing interleukin-1 (Il-1). Two experimental tools reported to interfere with the biological activity of IL-1 were used: antibodies directed against IL-1 receptors and alpha MSH. In a first series of experiments, adult male mice were injected with a lipopolysaccharide (LPS; 25 micrograms), antibodies against IL-1 receptor, alpha MSH (1-30 micrograms), or LPS and either IL-1 antibodies or alpha MSH. All treatments were administered ip. The endotoxin LPS caused a marked increase in plasma ACTH levels, measured 6 h later. Both alpha MSH and the Il-1 receptor antibodies, while having no effect by themselves, significantly (P less than or equal to 0.01) blocked LPS-induced ACTH release. In a second series of experiments, mice were injected ip with 500 ng recombinant human (rh) Il-1 alpha or 100 ng rhIl-1 beta in the presence or absence of alpha MSH (1-30 micrograms, ip). While not altering ACTH secretion induced by rhIl-1 alpha, 10-30 micrograms alpha MSH significantly (P less than or equal to 0.01) interfered with the effect of rhIl-1 beta. These results suggest 1) that endotoxin activates the hypothalamic-pituitary-adrenal axis through a mechanism involving the activation of interleukin-1 receptors; and 2) that the effect of rhIl-1 beta, but not -alpha, on ACTH secretion by the mouse can be partially blocked by alpha MSH.
Adaptive Process Control for Injection Molding (1990)

In recent years, process controls for injection molding have developed from simple open-loop systems to more sophisticated closed-loop systems that provide im proved quality of molded product, and greater productivity. In particular, closed-loop con trol of the injection step, involving closed loop-control of injection velocity during cavity filling, switch-over by pressure detection, and closed-loop control of the holding pressure, is a widely accepted methodology for maintaining high product quality.