gebhart/patrepeval huggingface dataset:
Autocrine Regulation of Eotaxin in Normal Human Bronchial Epithelial Cells (2000)

Normal human bronchial epithelial cells (NHBECs) spontaneously synthesize and store chemokines including eotaxin, RANTES, or MCP-3. We also observed the constitutive expression of mRNA specific for CC chemokine receptor-3 (CCR3) in these cells. The stimulation of these cells by eotaxin (1-100 ng/ml) dose-dependently increased eotaxin production. In addition, RANTES or eotaxin-2 but not MCP-3 at the higher concentrations (100 ng/ml), also induced slight eotaxin production. Eotaxin elicited the expression of eotaxin mRNA at 6 h after stimulation. Antibody against eotaxin or CCR3, and actinomycin D inhibited these effects of eotaxin. These antibodies also significantly inhibited the ability of eotaxin to produce further eotaxin. These findings strongly suggest that eotaxin which originates from inflammatory cells or cells resident in the airway of bronchial asthmatics can induce further production of eotaxin and participate in expansion of allergic inflammation.
Original method for features extraction and vectorization: application to cadastral maps (2002)

The aim of the interpretation of documents is to extract as automatically as possible their characteristic elements in order to store them as object instead of pixel. The paper deals with a cadastral map interpretation device. The authors' approach to solve this problem is two fold : first, it consists of vectorizing the image by extracting the lowest information level, then, using the low level primitives and introducing the knowledge of the cadastral map, it reconstructs real cadastral entities. First, the authors present the decomposition of the information into different levels of abstraction (from the low level information to the real cadastral object). The authors also present the interactions between these different levels, interactions which are managed by the coherence of the objects on each of the different levels. The authors present the different original tools allowing the extraction of low level primitives.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Biological therapies for inflammatory bowel disease (2010)

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, represents a heterogenic group of chronic diseases with a high morbidity and poor prognosis. The etiology of IBD is still unknown, and the pathogenesis of IBD has not been fully clarified. Consequently, the clinical outcome of IBD is unsatisfying. Fortunately, a variety of new biological therapies have being developed in recent years. These therapies are shown to be helpful in inducing remission, preventing complications, improving l i fe quality of the patients, and reducing hospitalization rates and surgical rates. This article will review these new biological agents clinically used for IBD patients.
Epidemiology of laryngeal cancer: Results of the Heidelberg case-control study (1997)

Maier H, Tisch M, Epidemiology of laryngeal cancer. Resulty of the Heidelberg case-control study. Acta Otolaryngol (Stockh) 1997; Suppl 527: 160-164.Squamous cell carcinoma of the larynx is a multifactorial disease which predominantly is found in males aged 50-70 years. Chronic consumption of alcohol and tobacco independently increase the relative risk of this type of cancer in a dose-dependent manner. Low educational standards and occupational training are associated with high risk. The majority of the cancer patients are blue collar workers who are exposed to a variety of hazardous working materials like polycylic aromatic hydrocarbons, cemept dust, metal dusts, asbestos. varnish, lacquer, etc. Environmental exposure to airborne carcinogens like fossil fuel single stove emissions may increase the relative risk of laryngeal cancer. The regular consumption of fruit. salad and dairy products which contain considerable amounts of tumor protective micronutrients may decrease the risk of laryngeal cancer.
Prostate Cancer Cells with Stem Cell Characteristics Reconstitute the Original Human Tumor <i>In vivo</i> (2007)

Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described in terms of Gleason score, a classification not applied to any of the transgenic mouse models currently developed to mimic human disease. Immunohistochemical and Western blot analyses indicate that they do not express androgen receptor or p63, similar to that reported for prostate stem cells. These cell lines also express embryonic stem markers (Oct4, Nanog, and Sox2) as well as early progenitor cell markers (CD44 and Nestin) in vitro. Clonally derived HPET cells reconstitute the original human tumor in vivo and differentiate into the three prostate epithelial cell lineages, indicating that they arise from a common stem/progenitor cell. Serial transplantation experiments reconstitute the tumors, suggesting that a fraction of parental or clonally derived HPET cells have self-renewal potential. Thus, this model may enhance our understanding of human tumor development and provide a mechanism for studying cancer stem/progenitor cells in differentiation, tumorigenesis, preclinical testing, and the development of drug resistance.
DustCart, a Mobile Robot for Urban Environments : Experiments of Pollution Monitoring and Mapping during Autonomous Navigation in Urban Scenarios (2010)

In the framework of DustBot European project, aimed at developing a new multi-robot system for urban hygiene management, we have developed a twowheeled robot: DustCart. DustCart aims at providing a ...
Efficient OMA DRM v2.0 ROAP for Protecting a Rights Object for a Device (2008)

Recently, the open mobile alliance (OMA) has been set to define open DRM technologic specifications to protect copyrighted content against piracy, unauthorized use and distribution over mobile networks. This paper proposes an efficient OMA DRM v2.0 ROAP for protecting a rights object for a device. Our proposed ROAP can offer a more efficient DRM system for future mobile networks.
MMX Mesalamine for Induction and Maintenance Therapy in Mild-to-Moderate Ulcerative Colitis. (2009)

Two 8-week, randomized, placebo-controlled parent studies, SPD476-301 (by Lichtenstein and associates) and SPD476-302 (by Kamm and colleagues), of MMX Multi Matrix System (MMX) mesalamine have evaluated the induction of remission in ulcerative colitis patients, and a third study has evaluated the maintenance of remission in patients from these parent studies. Here, we examine data only from patients who received MMX mesalamine 2.4 g or 4.8 g daily in these trials. In total, 63.6% of patients (220/346) achieved remission following 8-16 weeks of MMX mesalamine therapy. Among these 220 eligible patients, 218 entered the 12-month maintenance phase, and of this group, 89.9% (196/218) were relapse-free at study end. Overall, 56.6% (196/346) of patients who started MMX mesalamine therapy both achieved and maintained remission for 12 months. The adverse-event profile of MMX mesalamine was similar to the profile of the parent studies' placebo arms at all doses and frequencies. Therefore, the majority of patients with active, mild-to-moderate ulcerative colitis can achieve remission, including complete symptom resolution and mucosal healing, and remain relapse-free for at least 1 year with MMX mesalamine.
INVESTIGATION OF NUMERICAL TECHNIQUES AS APPLIED TO DIGITAL FLIGHT CONTROL SYSTEMS. (1967)

The report describes analytical techniques applicable to the design of on-line digital control systems and analysis of real-time hybrid simulations. Emphasis is placed on an operational mathematics approach using state variables and signal flow mapping techniques to facilitate stability analysis and accurate interpretation of results in terms of concepts familiar to Control Engineers. Digital simulation of a fourth-order pitch rate flight control system is included. A technique for analysis of nonlinear digital systems employing Lyapunov's Second Method is presented. Predictor-corrector methods for first-order and higher-order differential equations are discussed. Error analysis techniques are included with special attention given to quantization errors. A system synthesis technique employing constraint equations for determination of control system design parameter values is developed. (Author)
Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile (1994)

Conference Article| May 01 1994 Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile R. D. Stevens; R. D. Stevens † *Duke University Medical Center, Durham, NC, U.S.A. †Address for correspondence: Dr R. D. Stevens, Department of Pediatrics, Box 3028, Duke University Medical Center, Durham, NC 27710, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar J. Bonaventura; J. Bonaventura *Duke University Medical Center, Durham, NC, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar C. Bonaventura; C. Bonaventura *Duke University Medical Center, Durham, NC, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar T. R. Fennel; T. R. Fennel ‡Chemical Industry Institute of Toxicology, Research Triangle Park, NC, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar D. S. Millington D. S. Millington *Duke University Medical Center, Durham, NC, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (2): 543–547. https://doi.org/10.1042/bst0220543 Article history Received: December 16 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R. D. Stevens, J. Bonaventura, C. Bonaventura, T. R. Fennel, D. S. Millington; Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile. Biochem Soc Trans 1 May 1994; 22 (2): 543–547. doi: https://doi.org/10.1042/bst0220543 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: g.c.-m.s., gas chromatography mass spectrometry, e.s.i.-m.s., electrospray ionization mass spectrometry, ACN, acrylonitrile, MCA, multichannel analyser This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Role of p53 and Apoptosis in Cerebral Vasospasm after Experimental Subarachnoid Hemorrhage (2005)

Our previous studies indicate that apoptosis in endothelial cells of major cerebral arteries contributes to cerebral vasospasm after subarachnoid hemorrhage (SAH). This study examined the pathologic roles of tumor suppressor p-53 in cerebral vasospasm using an established dog double-hemorrhage model. Twenty mongrel dogs were divided into four groups: (1) control, (2) SAH, (3) SAH+DMSO (vehicle), and (4) SAH+pifithrin-alpha (PFT) (p53 inhibitor). The p53 inhibitor (200 nmol/L) was injected into the cisterna magna daily from Day 0 through Day 3. Angiogram was performed on Day 0 and Day 7. Western blot, cell proliferation assay, histology, and TUNEL staining were conducted on the basilar arteries collected on Day 7 after SAH. The arterial diameter on Day 7 was 42%+/-4%, 40%+/-5%, and 59%+/-4% for SAH, SAH+DMSO, and SAH+PFT, respectively. In addition, positive staining of TUNEL and increased protein expression of p53, Bax, and PCNA in the basilar artery were observed on Day 7. PFT suppressed apoptosis in endothelial cells and proliferation in smooth muscle cells, and attenuated angiographic vasospasm. In conclusion, p53 may be a key factor in endothelial apoptosis and smooth muscle proliferation after SAH. Inhibition of p53 may potentially reduce or even prevent cerebral vasospasm.
Interaction of heparin and antithrombin III (1988)

A synthetic pentasaccharide corresponding to the sequence involved in heparin for binding and activation of antithrombin III contains eight sulfate groups. The role of some of them in the interaction with the protein has been demonstrated through the study of fragments obtained from heparin. An approach based on the total chemical synthesis of heparin fragments allows us to provide new information on the O-sulfate groups borne by the iduronic acid and the glucosamine units that constitute the reducing-end disaccharide of the above pentasaccharide sequence. Although not strictly necessary for a weak interaction to take place, these two sulfates co-operate to express maximal activity. This suggests that they belong to a secondary sub-region of interaction with antithrombin III, the primary one being accounted for by other critical parts of the structure and particularly the trisaccharide sequence placed at the non-reducing end of the pentasaccharide.
End-to-end ASR: from Supervised to Semi-Supervised Learning with Modern Architectures (2019)

We study pseudo-labeling for the semi-supervised training of ResNet, Time-Depth Separable ConvNets, and Transformers for speech recognition, with either CTC or Seq2Seq loss functions. We perform experiments on the standard LibriSpeech dataset, and leverage additional unlabeled data from LibriVox through pseudo-labeling. We show that while Transformer-based acoustic models have superior performance with the supervised dataset alone, semi-supervision improves all models across architectures and loss functions and bridges much of the performance gaps between them. In doing so, we reach a new state-of-the-art for end-to-end acoustic models decoded with an external language model in the standard supervised learning setting, and a new absolute state-of-the-art with semi-supervised training. Finally, we study the effect of leveraging different amounts of unlabeled audio, propose several ways of evaluating the characteristics of unlabeled audio which improve acoustic modeling, and show that acoustic models trained with more audio rely less on external language models.
Lower bounds on the maximum cross correlation of signals (Corresp.) (1974)

Some communication systems require sets of signals with impulse-like autocorrelation functions and small cross correlation. There is considerable literature on signals with impulse-like autocorrelation functions hut little on sets of signals with small cross correlation. A possible reason is that designers put too severe a restriction on cross correlation magnitudes. This correspondence establishes lower bounds on how small the cross correlation and autocorrelation can simultaneously be.
A Trace Gas Sensor at ppb Sensitivity Based On Multiple Line Integration Spectroscopy Techniques (2010)

We demonstrate that employing integrated absorption of multiple lines or summation of the absolute values of the wavelength modulation spectroscopy signals, sensitivities of ppb can be achieved for the detection of trace gases.
Implications of Salt and Sodium Reduction on Microbial Food Safety (2010)

Excess sodium consumption has been cited as a primary cause of hypertension and cardiovascular diseases. Salt (sodium chloride) is considered the main source of sodium in the human diet, and it is estimated that processed foods and restaurant foods contribute 80% of the daily intake of sodium in most of the Western world. However, ample research demonstrates the efficacy of sodium chloride against pathogenic and spoilage microorganisms in a variety of food systems. Notable examples of the utility and necessity of sodium chloride include the inhibition of growth and toxin production by Clostridium botulinum in processed meats and cheeses. Other sodium salts contributing to the overall sodium consumption are also very important in the prevention of spoilage and/or growth of microorganisms in foods. For example, sodium lactate and sodium diacetate are widely used in conjunction with sodium chloride to prevent the growth of Listeria monocytogenes and lactic acid bacteria in ready-to-eat meats. These and other examples underscore the necessity of sodium salts, particularly sodium chloride, for the production of safe, wholesome foods. Key literature on the antimicrobial properties of sodium chloride in foods is reviewed here to address the impact of salt and sodium reduction or replacement on microbiological food safety and quality.
Structure and properties of three powder metallurgically processed Al-Cu-Mg alloys (1980)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1980.
Iowa Swiss-type cheese (1938)

New types of cheese for Iowa have been receiving the attention of the Iowa Agricultural Experiment Station for a number of years. A previous publication (1) described the method of manufacture which has been used in the production of many thousands of pounds of Iowa Blue Cheese. This publication deals with the process used in the Iowa State College laboratories in manufacturing a Swiss-type cheese. In the course of these experiments a total of 25,136 lbs. of the cheese has been manufactured and marketed, utilizing approximately a quarter of a million pounds of milk.
Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance (2014)

Glucocorticoids, such as dexamethasone, enhance protein breakdown via ubiquitin-proteasome system. However, the role of autophagy in organelle and protein turnover in the glucocorticoid-dependent atrophy program remains unknown. Here, we show that dexamethasone stimulates an early activation of autophagy in L6 myotubes depending on protein kinase, AMPK, and glucocorticoid receptor activity. Dexamethasone increases expression of several autophagy genes, including ATG5, LC3, BECN1, and SQSTM1 and triggers AMPK-dependent mitochondrial fragmentation associated with increased DNM1L protein levels. This process is required for mitophagy induced by dexamethasone. Inhibition of mitochondrial fragmentation by Mdivi-1 results in disrupted dexamethasone-induced autophagy/mitophagy. Furthermore, Mdivi-1 increases the expression of genes associated with the atrophy program, suggesting that mitophagy may serve as part of the quality control process in dexamethasone-treated L6 myotubes. Collectively, these data suggest a novel role for dexamethasone-induced autophagy/mitophagy in the regulation of the muscle atrophy program.
Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases (2019)

The central nervous system is characterized by a high content of sphingolipids and by a high diversity in terms of different structures. Stage- and cell-specific sphingolipid metabolism and expression are crucial for brain development and maintenance toward adult age. On the other hand, deep dysregulation of sphingolipid metabolism, leading to altered sphingolipid pattern, is associated with the majority of neurological and neurodegenerative diseases, even those totally lacking a common etiological background. Thus, sphingolipid metabolism has always been regarded as a promising pharmacological target for the treatment of brain disorders. However, any therapeutic hypothesis applied to complex amphipathic sphingolipids, components of cellular membranes, has so far failed probably because of the high regional complexity and specificity of the different biological roles of these structures. Simpler sphingosine-based lipids, including ceramide and sphingosine 1-phosphate, are important regulators of brain homeostasis, and, thanks to the relative simplicity of their metabolic network, they seem a feasible druggable target for the treatment of brain diseases. The enzymes involved in the control of the levels of bioactive sphingoids, as well as the receptors engaged by these molecules, have increasingly allured pharmacologists and clinicians, and eventually fingolimod, a functional antagonist of sphingosine 1-phosphate receptors with immunomodulatory properties, was approved for the therapy of relapsing-remitting multiple sclerosis. Considering the importance of neuroinflammation in many other brain diseases, we would expect an extension of the use of such analogs for the treatment of other ailments in the future. Nevertheless, many aspects other than neuroinflammation are regulated by bioactive sphingoids in healthy brain and dysregulated in brain disease. In this review, we are addressing the multifaceted possibility to address the metabolism and biology of bioactive sphingosine 1-phosphate as novel targets for the development of therapeutic paradigms and the discovery of new drugs.
Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3/arginase-I signaling in patients with ankylosing spondylitis (2018)

STAT3/arginase-I signaling plays an important role in both the expansion and activation of M-MDSCs in patients with AS. This information may be beneficial in developing novel therapeutic strategies for preventing AS.
High-pressure synthesis, characterization, and equation of state of cubic C-BN solid solutions (1995)

Synthesis of several samples across the cubic ${\mathrm{C}}_{\mathit{x}}$(BN${)}_{1\mathrm{\ensuremath{-}}\mathit{x}}$ solid solution (x=0.3--0.33,0.5,0.6) at pressures in excess of 30 GPa and temperatures above 1500 K indicates that they are isostructural with diamond and cubic BN (borazon). Measurement of the lattice parameters of C-BN samples quenched to ambient conditions shows that the solid solution between C (diamond) and cubic BN is nonideal, with unit-cell volumes up to 1% larger than predicted based on ideal mixing (Vegard's law). In addition, we have measured the zero-pressure, 300-K vibrational spectra for ${\mathrm{C}}_{0.3}$(BN${)}_{0.7}$. In the midinfrared absorption spectrum, we observe a reststrahlen band ranging from 1000--1120 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$, and the Raman spectrum has a longitudinal optic mode at 1323(\ifmmode\pm\else\textpm\fi{}2) ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$. Based on a comparison of the spectrum with that of diamond and cubic BN, we conclude that the bonding in cubic C-BN is partially ionic. In addition to these measurements on quenched samples, we have measured the isothermal bulk modulus of ${\mathrm{C}}_{0.33}$(BN${)}_{0.67}$ by x-ray diffraction through a diamond cell to over 100 GPa at 300 K. The bulk modulus is 355(\ifmmode\pm\else\textpm\fi{}19) GPa, which is lower than those of diamond, cubic BN and the value predicted from ideal mixing between the end members, but is consistent with the nonideal expansion observed for the cubic C-BN lattice parameters.
Revisiting Fred Iklé's 1961 question, “after detection—What?” (2001)

Dr. Brad Roberts is a Research Staff Member at the Institute for Defense Analyses in Alexandria, Virginia. He is also an Adjunct Professor at George Washington University, Chairman of the research advisory council of the Chemical and Biological Arms Control Institute, and a member of The Nonproliferation Review’s editorial board. He is the author of Weapons Proliferation and World Order After the Cold War (Kluwer Press, 1996).