gebhart/patrepeval huggingface dataset:
Assignment of the Charcot-Marie-Tooth neuropathy type 1 (CMT 1a) gene to 17p11.2-p12. (1990)

Charcot-Marie-Tooth disease type 1a (CMT 1a) is an autosomal dominant peripheral neuropathy linked to the DNA markers D17S58 and D17S71, located in the pericentromeric region of the chromosome 17p arm. We analyzed an extended 5-generation Belgian family, multiply affected with CMT 1a, for linkage with eight chromosome 17 markers. The results indicated that the CMT 1a mutation is localized in the chromosomal region 17p11.2-p12 between the marker D17S71 and the gene for myosin heavy polypeptide 2 of adult skeletal muscle.
Singly-polarized reconfigurable slot-ring antenna/array with fractal shapes (2016)

A reconfigurable fractal-shaped slot-ring antenna with wide bandwidth is presented. The antenna is able to switch between two modes using 8 PIN diode switches. In the first mode, the proposed antenna operates at S band with 70% fractional bandwidth (FBW). In the second mode of operation, the antenna covers C band with 67% FBW. Fractal shapes are incorporated into the antenna structure to significantly increase the bandwidth at both operating modes. Good radiation parameters over the entire bandwidth are also obtained for both modes.
Design of a system to measure light scattering from individual cells excited by an acoustic wave (2008)

A system to measure light scattering from individual cells excited by an acoustic wave was designed, and tests were performed on live Jurkat cells. Cells passing in a laminar stream within a water bath were excited by a focused ultrasound pulse, while the scattered light from a laser beam was monitored at various scattering angles. The cells were modeled as viscoelastic liquid drops, which return to equilibrium via shape oscillations after an acoustically-induced deformation. The Fast Fourier Transform of the scattered light signal was used to extract information about the highly-damped resonant frequencies of the cells, and the detected frequencies are consistent with theoretical predictions.
High-level area and power estimation for VLSI circuits (1997)

This paper addresses the problem of computing the area complexity of a multi-output combinational logic circuit, given only its functional description, i.e., Boolean equations, where area complexity is measured in terms of the number of gates required for an optimal multi-level implementation of the combinational logic. The proposed area model is based on transforming the given multi-output Boolean function description into an equivalent single-output function. The model is empirical, and results demonstrating its feasibility and utility are presented. Also, a methodology for converting the gate count estimates, obtained from the area model, into capacitance estimates is presented. High-level power estimates based on the total capacitance estimates and average activity estimates are also presented.
C-terminal Deletions of the Escherichia coli RecA Protein (2003)

A set of C-terminal deletion mutants of the RecA protein of Escherichia coli, progressively removing 6, 13, 17, and 25 amino acid residues, has been generated, expressed, and purified. In vivo, the deletion of 13 to 17 C-terminal residues results in increased sensitivity to mitomycin C. In vitro, the deletions enhance binding to duplex DNA as previously observed. We demonstrate that much of this enhancement involves the deletion of residues between positions 339 and 346. In addition, the C-terminal deletions cause a substantial upward shift in the pH-reaction profile of DNA strand exchange reactions. The C-terminal deletions of more than 13 amino acid residues result in strong inhibition of DNA strand exchange below pH 7, where the wild-type protein promotes a proficient reaction. However, at the same time, the deletion of 13-17 C-terminal residues eliminates the reduction in DNA strand exchange seen with the wild-type protein at pH values between 7.5 and 9. The results suggest the existence of extensive interactions, possibly involving multiple salt bridges, between the C terminus and other parts of the protein. These interactions affect the pK(a) of key groups involved in DNA strand exchange as well as the direct binding of RecA protein to duplex DNA.
Le vieillissement au travail et en emploi : bilan synthèse des travaux récents (2002)

Ce bilan synthèse souligne la place marginale qu'occupent les travaux sur le vieillissement au travail et en emploi, malgré la centrante du travail dans les sociétés industrielles avancées et les conséquences importantes des conditions de travail et des itinéraires professionnels antérieurs pour la vie à la retraite. Le champ de la vieillesse et du vieillissement étant délimité à partir de critères d'âge et d'exclusion du marché du travail, le rôle du travail et de l'emploi en tant que facteurs structurants du processus de vieillissement est occulté. Les travaux sur cette question sont relativement peu nombreux, bien qu'en croissance depuis la dernière décennie. On peut les partager en trois grandes catégories, selon leurs objets d'analyse: 1) les analyses des statistiques sur la population active, 2) les études des politiques et pratiques des entreprises et de leurs effets sur la main-d'œuvre vieillissante et 3) les études sur différentes catégories de travailleuses et de travailleurs vieillissants. En conclusion, le peu d'influence de ces travaux de recherche sur les acteurs sociaux concernés est attribuée à la faible intervention de l'État dans la vie économique et dans les activités des entreprises privées.
THE SALT SPRAY CORROSION OF POLYMER COATING ON STEEL (2015)

This study reports on the salt spray corrosion of polymer coating on steel substrate. In the process, firstly, steel coupons are sand blasted, chemically cleaned, and phosphated in different time periods, then the surface of steel is coated with an epoxy-polyester layer at different thicknesses which range from 50 to 180 µm and then they are cured at 200 °C for 20 min. in a liquid petroleum gas atmosphere. The corrosion test was performed in salt solution, which consists of 5 % NaCl, for over 2000 hours. The relative humidity of cabinet was 100 % and the temperature of it was 35 °C. The corroded samples were examined with a high resolution camera and a stereo microscope. The pH of sprayed and collected water changed between 6.5 and 7.2. The conductivity of water used were arranged as 10 µS by
Real-time QoE estimation of DASH-based mobile video applications through edge computing (2018)

Video applications using MPEG-DASH (Dynamic Adaptive Streaming over HTTP, such as YouTube and Netflix) have been dominating the Internet traffic in recent years. It is increasingly acknowledged that in order to provide video clients with better Quality-of-Experience (QoE), both content service providers and network operators need to be aware of clients' QoE in the first place. In this paper, we present a novel real-time QoE estimation system through edge computing, which has been implemented and deployed at a real LTE-A network edge. When equipped with such a system, any virtual network function (VNF) deployed in a mobile network will be able to infer all DASH clients' QoE under its coverage in real time, where no feedback from clients are needed. Furthermore, our scheme is able to work robustly in busy network environments involving air interface where packet errors frequently occur. The significance of such a scheme is the availability of accurate and real-time knowledge on user QoE through a very lightweight mechanism at the mobile edge, which can be instantaneously used for various content manipulation or resource adaptation operations in order to assure user QoE in dynamic conditions. Through experiments in a real LTE-A network, we demonstrate that our scheme is able to estimate DASH clients' QoE with very high accuracy with very low CPU and RAM footprint.
Utilization of a labeled tracking oligonucleotide for visualization and quality control of spotted 70-mer arrays (2004)

This novel approach enables prehybridization array visualization for spotted oligonucleotide arrays and sets the stage for more sophisticated slide qualification and data filtering applications.
Photon-number-resolving superconducting nanowire detectors (2015)

In recent years, photon-number-resolving (PNR) detectors have attracted great interest, mainly because they can play a key role in diverse application fields. A PNR detector with a large dynamic range would represent an ideal photon detector, bringing the linear response of conventional analogue detectors down to the single-photon level. Several technologies, such as InGaAs single photon avalanche detectors (SPADs), arrays of silicon photomultipliers, InGaAs SPADs with self-differencing circuits and transition edge sensors have shown photon number resolving capability. Superconducting nanowires provide free-running single-photon sensitivity from visible to mid-infrared frequencies, low dark counts, excellent timing resolution (
Cell Aggregation Assays (2003)

Invasion of carcinoma cells is the result of a disequilibrium between invasion promoter and invasion suppressor gene products (1). The E-cadherin/catenin complex is the most potent invasion suppressor at the cell membrane of epithelioid cells (2).This complex consists of E-cadherin, a transmembrane glycoprotein of 120 kDa, which is linked to the actin cytoskeleton via the catenins (3). Downregulation of the complex is a common feature in invasive carcinoma cells, and has been recognized at several levels, ranging from genomic mutations to functional deficiencies of an apparently intact complex (4). Cell aggregation assays have been set up to test the functionality of the complex in epithelioid tumor cells. Functional integrity of the complex is a prerequisite for cell-cell adhesion between epithelial cells, and measuring cell aggregation in vitro has thus become another elegant tool to study differences between invasive and noninvasive cell types.
The rigorous CAD of aperture-coupled T-junction bandstop-filters, E-plane circuit elliptic-function filters, and diplexers (2002)

The rigorous computer-aided design (CAD) of waveguide bandstop filters, elliptic-function E-plane integrated circuit filters with additional bandstop cavities, and high-return-loss E-plane T-junction diplexers with iris matching elements is introduced. Based on the general rectangular waveguide T-junction key building block modal S-matrix, the design takes into account both the finite thickness of all coupling elements and the higher order mode interaction at all step discontinuities. The theory is verified by measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solvent extraction and recovery of the transuranic elements from waste solutions using the TRUEX process (1985)

High-level liquid waste is produced during the processing of irradiated nuclear fuel by the PUREX process. In some cases the treatment of metallurgical scrap to recover the plutonium values also generates a nitric acid waste solution. Both waste solutions contain sufficient concentrations of transuranic elements (mostly /sup 241/Am) to require handling and disposal as a TRU waste. This paper describes a recently developed solvent extraction/recovery process called TRUEX (transuranium extraction) which is designed to reduce the TRU concentration in nitric waste solutions to <100 nCi/g of disposed form (1,2). (In the USA, non-TRU waste is defined as <100 nCi of TRU/g of disposed form.) The process utilizes PUREX process solvent (TBP in a normal paraffinic hydrocarbon or carbon tetrachloride) modified by a small concentration of octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (abbrev. CMPO). The presence of CMPO enables the modified PUREX process solvent to extract trivalent actinides as well as tetra- and hexavalent actinides. A major feature of the TRUEX process is that is is applicable to waste solutions containing a wide range of nitric acid, salt, and fission product concentrations and at the same time is very compatible with existing liquid-liquid extraction technology as usually practiced in a fuel reprocessing plant. To date the process has been tested on two different types of synthetic waste solutions. The first solution is a typical high-level nitric acid waste and the second a typical waste solution generated in metallurgical scrap processing. Results are discussed. 4 refs., 1 fig., 4 tabs.
Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene (2001)

ABSTRACT Hypoxia, a stimulus for angiogenesis and vascular remodeling, has been proposed to use reactive oxygen species as second messengers in signal transduction. This contention remains controversial, in part because of vagaries associated with fluorescence‐based methods of free‐radical detection. We took a different approach. Rat main pulmonary artery endothelial cells (PAECs) were cultured in hypoxia for up to 48 h, and, with dichlorofluorescein fluorescence to detect free‐radical production, we used quantitative Southern blot and ligation‐mediated PCR analyses to search for oxidative modifications in the mitochondrial genome and in the nuclear vascular endothelial cell growth factor (VEGF) gene. In accord with previous studies in other cell types, we found that acute hypoxic exposure promoted time‐dependent dichlorofluorescein fluorescence in PAECs. Quantitative Southern blot analysis showed that although hypoxia failed to alter mitochondrial DNA integrity, prominent oxidative lesions occurred in a 5.0‐kb sequence of the VEGF promoter. Using ligation‐mediated PCR to map the modifications at single nucleotide resolution, we found clusters of oxidized bases in a VEGF promoter sequence that included the AP‐1 and HIF‐1 response elements. These actions of hypoxia differed from exogenous xanthine oxidase, which obliterated the mitochondrial genome but failed to erode integrity of the VEGF promoter. Our observations indicate that hypoxia promotes an oxidant stress in main PAECs as detected by oxidative base modifications in the nuclear VEGF gene. The presence of hypoxia‐induced, oxidative base modifications in functionally significant sequences within the VEGF promoter suggests new concepts for mechanisms by which reactive oxygen species participate in hypoxic signal transduction.
CMP properties and fabrication of OLED using MEH‐PPV (2008)

Abstract The interface between the electrode and organic layer in organic light emitting diode (OLED) has been reported as an important factor to influence the electrical and luminescent properties. Indium tin oxide (ITO) is commonly used as the anode material. ITO thin film has been deposited on glass substrate by radio frequency (RF) magnetron sputtering. And it was used as an anode contact to fabricate OLED device. The OLED devices with ITO/MEH‐PPV [2‐methoxy‐5‐(2‐ethylhexyloxy)‐p‐phenylenevinylene]/Al configuration were fabricated by thermal evaporation and spin coating, respectively. We investigated the electrical, structural and optical properties of ITO thin film, which was measured using the methods of atomic force microscope (AFM), field‐emission scanning electron microscope (FESEM) and ultraviolet–visible (UV–VIS) spectrophotometer. The interface property between ITO thin film and MEH‐PPV was improved as the surface of ITO thin film was smoothed and photoluminescence (PL) intensity was increased in the 680 nm range. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Bitmap based algorithms for mining association rules. (1998)

A simple approach to identifying barriers to change appears to have been adequate and efficient. However, we do not know for certain what we would have gained by using more comprehensive methods and we do not know whether the resulting intervention would have been more effective if we had used other methods. The effectiveness of our multifaceted intervention is under evaluation in a randomised controlled trial.
Effect of Reaction Parameters on Synthesis of Citronellyl Methacrylate by Lipase‐Catalyzed Transesterification (2003)

The methacrylate ester of citronellol was synthesized using various lipases as catalyst. The effect of different reaction parameters such as amount of lipase, solvent, temperature, and acylating agent on the conversion of citronellol to citronellyl methacrylate was studied. Methyl methacrylate, vinyl methacrylate, and 2,3-butanedione mono-oxime methacrylate were used as acylating agents. Porcine pancreatic lipase (PPL), Candida rugosa lipase (CRL), and Pseudomonas cepacia lipase (Amano-PS) were used as biocatalysts. Diisopropyl ether (DIPE) was found to be the most suitable solvent. The stereoselectivity of CRL in transesterification of (+/-)-citronellol was tested for the optimized reaction parameters.
A distributed timing synchronization technique for parallel multi-core instruction-set simulation (2013)

As multi-core architecture has become the mainstream, the corresponding multi-core instruction-set simulation (MCISS) is also needed to aid system development. Ideally, we may run a MCISS in parallel to enhance the simulation speed. However, the conventional centralized timing synchronization mechanism would greatly constrain the parallelism of a MCISS, so the simulation speed is bounded. To resolve this issue, we propose a new distributed timing synchronization technique which allows higher parallelism for a MCISS. Hence, it accelerates the simulation speed by 9 to 20 times as the number of cores increases in contrast to the centralized synchronization approach.
Magnetic reconnection of plasma toroids with cohelicity and counterhelicity (1990)

Magnetic reconnection phenomena are investigated taking into account all three vector components of the magnetic field in a laboratory experiment. Two toroidal magnetized plasmas carrying identical toroidal currents and poloidal field configurations are made to collide, thereby inducing magnetic reconnection. The direction of the toroidal field plays an important role in the merging process. It is found that plasmas of antiparallel helicity merge much faster than those of parallel helicity. It is also found that the reconnection rate is proportional to the initial relative velocity of the two plasma tori, suggesting that magnetic reconnection, in the present experiment, is a forced phenomenon.
Which code construct metrics are symptoms of post release failures? (2011)

Software metrics, such as code complexity metrics and code churn metrics, are used to predict failures. In this paper we study a specific set of metrics called code construct metrics and relate them to post release failures. We use the values of the code construct metrics for each file to characterize that file. We analyze the code construct metrics along with the post release failure data on the files (that splits the files into two classes: files with post release failures and files without post release failures). In our analysis we compare a file with post release failure to a set of files without post release failures, that have similar characteristics. In our comparison we identify which code construct metric, more often than the others, differs the most between these two classes of files. The goal of our research is to find out which code construct metrics can perhaps be used as symptoms of post release failures. In this paper we analyzed the code construct metrics of Eclipse 2.0, 2.1, and 3.0. Our results indicate that MethodInvocation, QualifiedName, and SimpleName, are the code constructs that differentiates the two classes of files the most and hence are the key symptoms/indicators of a file with post release failures in these versions of Eclipse.
Ten years' experience in a general practice obstetric unit. (1980)

The outcomes of over 8,000 bookings in a general practice obstetric unit closely associated with a consultant unit were surveyed prospectively over a 10-year period. There was a progressive (though erratic) reduction in perinatal mortality rates for all original bookings and for final admissions in general practice care though these appeared to be at the expense of an increasing transfer rate for primiparae both during pregnancy and in labour. The performance of general practice obstetricians was also examined and the implications for the future of general practice obstetrics are discussed.
A trichromatic colorimeter with spectral primaries (1928)

The paper describes a trichromatic colorimeter that has been specially designed in order to make an accurate re-determination of the locus of the spectral colours in the colour triangle for as many observers as possible. A spectrometer system is used in which two spectra are formed from the same source. From one of these, three portions to act as primaries are reflected back through a lower part of the dispersing system, so that the mixing of the three radiations is effected by neutralising the prismatic dispersion by which the colours were first separated. From the other spectrum the test colour and a desaturating colour are selected and mixed in a similar manner, and the composite beams are then brought into the two halves of a simple bipartite field. In the process of being mixed with the other colours, each spectral colour is filtered by its return passage through the dispersing system and the instrument thus becomes very effective in removing stray light. Another device has enabled the Maxwellian method of observing the field of view to be adopted without the introduction of rotating parts into the system. The intensities of the three primaries are controlled with photometer wedges.
Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme (2005)

The insect GST (glutathione transferase) supergene family encodes a varied group of proteins belonging to at least six individual classes. Interest in insect GSTs has focused on their role in conferring insecticide resistance. Previously from the mosquito malaria vector Anopheles dirus, two genes encoding five Delta class GSTs have been characterized for structural as well as enzyme activities. We have obtained a new Delta class GST gene and isoenzyme from A. dirus, which we name adGSTD5-5. The adGSTD5-5 isoenzyme was identified and was only detectably expressed in A. dirus adult females. A putative promoter analysis suggests that this GST has an involvement in oogenesis. The enzyme displayed little activity for classical GST substrates, although it possessed the greatest activity for DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)ethane] observed for Delta GSTs. However, GST activity was inhibited or enhanced in the presence of various fatty acids, suggesting that the enzyme may be modulated by fatty acids. We obtained a crystal structure for adGSTD5-5 and compared it with other Delta GSTs, which showed that adGSTD5-5 possesses an elongated and more polar active-site topology.
A class of A(N &#x002B; C) codes and its properties (1985)

We discuss here a new class of arithmetic codes, called A(N + C) codes where A and C are constant positive integers, N is information to be coded. A(N + C) codes are a special case of AN + B arithmetic codes which were first studied by Brown. AN codes are linear and cannot be used to detect unidirectional multiple errors. A(N + C) codes are nonlinear and are useful for detecting and/or correcting symmetric errors, arithmetic errors and unidirectional errors. Furthermore, A(N + C) codes can be constructed to provide constant-weight, self-complementing and cyclic-code properties. It is apparent that the codes with these properties have, in some sense, broader capabilities of error detection and error correction.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative Alkyne Annulation by C—H Activation on Ketimines. (2014)

Abstract Carboxylate‐assisted ruthenium catalysis enables the oxidative annulation of alkynes by ketimines to form isoquinoline derivatives (III).