gebhart/patrepeval huggingface dataset:
Ki‐1 (CD30) antigen is released by Ki‐1‐positive tumor cells <i>in vitro</i> and <i>in vivo</i>. I. Partial characterization of soluble Ki‐1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme‐linked immunosorbent assay (1989)

An enzyme-linked immunosorbent assay (ELISA) has been developed that allows the quantitative determination of the Ki-1 (CD30) antigen in soluble form. Similar levels of sensitivity of this new Ki-1 ELISA and the ELISA previously described for measuring the soluble 55-kDa chain of the interleukin 2 receptor were seen. As assessed with this ELISA, the investigated Ki-1+ permanent cell lines released the Ki-1 antigen into the culture supernatant. In culture supernatants of concanavalin A-activated human peripheral blood lymphocytes, however, this antigen could not be detected. The released Ki-1 antigen has an apparent molecular weight (Mr) of 85,000, whereas the cell-associated Ki-1 antigen has an Mr of 105,000. We investigated sera from 30 normal donors, 15 patients with systemic infections, and 63 patients suffering from lymphomas for soluble Ki-1 antigen. In all sera from normal donors and patients with systemic infectious diseases, soluble Ki-1 antigen was below the detection limit (i.e., less than 70 pg). In contrast, high amounts of the soluble Ki-1 antigen were found in sera from 18 malignant lymphomas containing Ki-1+ tumor cells. This finding demonstrates that the release of the Ki-1 antigen takes place not only in vitro, but in vivo as well. Moreover, these results imply that the Ki-1 antigen may be used as a serum tumor marker.
Eu[sup 2+]-Doped High-Temperature Phase Ca[sub 3]SiO[sub 4]Cl[sub 2] (2005)

In this paper, we synthesized a novel yellowish orange phosphor, -doped high-temperature phase (HTP) at 1020°C. The primary crystal structure of is determined as monoclinic structure with a space group of . The excitation spectrum of -doped exhibits a broad-band between 250 and 500 nm with three peaks of around 327, 371, and 426 nm, which are coupled well with the near-UV (n-UV) or deep blue emission of GaN-based light-emitting diodes (LEDs). Its emission spectrum shows a single intense broad emission band centered at 572 nm. The measured chromaticity of yellowish orange luminescence is , . -doped would be suitable for yellowish orange phosphor of white LED because is excellent in the excitation spectral profile and the chromaticity.
Arterial Flow in The Lower Leg Correlated With Plasma Levels of Two Formulations of Papaverine Hydrochloride (1978)

In patients with severe peripheral vascular disease (mean arterial flow of 40 ml/min), a suspension of papaverine in a soft gelatin capsule produced plasma levels almost three times higher than those following treatment with a sustained- release tablet formulation. The higher plasma levels resulted in significantly greater vasodilation with increased distal arterial flow. The onset of peak pulsatile flow with the soft gelatin form came sooner than with the sustained- release form. However the durations of vasodilation were similar with both papaverine preparations. The vasodilatory activity of papaverine appeared to be greater in the sympathectomized leg. The soft gelatin formulation of papaverine may be an orally active vasodila tor, maintaining a distal runoff after reconstruction of a large artery, and may be effective in sustaining a longer vasodilatory effect in patients with small vessel disease, when surgical procedures may not be applicable.
Phase calibration for attenuating phase-shift masks (2006)

As metrology tolerances for photomasks become increasingly tight, the issues of measurement methods and calibration standards become more and more important. This is as true for optical phase metrology as it is for dimensional metrology. To first order, an optical phase standard can be defined by etching a step or trench into a transparent medium like fused silica with a well-characterized index of refraction. The normal-incidence phase shift of such a structure can be calculated with accuracy limited mainly by our ability to measure the physical depth of the trench. Other methods exist for measuring optical phase shifts in alternating aperture masks. For example a Levenson grating exhibits symmetrical behavior through focus only if the phase difference between the phase shifted and unshifted openings is exactly 180°. A measured asymmetry between the phase shifted and unshifted clear features in such a grating can be used to quantitatively measure the deviation from 180° optical phase. This approach is particularly attractive because the measurement can be made on an aerial image metrology system with the numerical aperture and illumination conditions used by the wafer stepper that will eventually project the mask. Calibration of optical phase in attenuating phase masks is more difficult. Until now there has been no accurate way to create and verify a calibration artifact. In this paper we discuss a new phase metrology pattern for attenuating phase masks. The phase error of this pattern can be determined to high accuracy by aerial image measurements. This pattern can be used to create an optical phase standard for calibrating phase metrology equipment for attenuated phase masks, or as a witness pattern on a product mask to verify the phase accuracy of that mask.
Pneumococcal Capsular Polysaccharide-Meningococcal Outer Membrane Protein Complex Conjugate Vaccines: Immunogenicity and Efficacy in Experimental Pneumococcal Otitis Media (1993)

Vaccines composed of pneumococcal capsular polysaccharides (PS) conjugated to outer membrane protein complex (OMPC) from Neisseria meningitides group B bacteria were tested in the chinchilla otitis media model. Monovalent (types 6B and 23F), bivalent (6B+23F), and tetravalent (6B+14+19F+23F) PS-OMPC conjugate vaccines elicited significant total serum antibody responses against all four PS. Type 6B vaccine elicited IgG, IgM, and IgA antibodies after a single dose and an anamnestic IgG response after a second vaccine dose on day 28. Type 6B and 19F vaccines prevented or greatly attenuated pneumococcal otitis media after direct middle ear challenge with the immunizing serotype, type 14 vaccine was not protective by this challenge route, and type 23F pneumococci were not sufficiently virulent in chinchillas to test vaccine effectiveness. The promising results with two serotypes suggest the PS-OMPC conjugates may be useful in human infants.
<scp>PD</scp>‐L1 expression is mainly regulated by interferon gamma associated with <scp>JAK</scp>‐<scp>STAT</scp> pathway in gastric cancer (2017)

Despite multidisciplinary treatment for patients with advanced gastric cancer, their prognosis remains poor. Therefore, the development of novel therapeutic strategies is urgently needed, and immunotherapy utilizing anti-programmed death 1/-programmed death ligand-1 mAb is an attractive approach. However, as there is limited information on how programmed death ligand-1 is upregulated on tumor cells within the tumor microenvironment, we examined the mechanism of programmed death ligand-1 regulation with a particular focus on interferon gamma in an in vitro setting and in clinical samples. Our in vitro findings showed that interferon gamma upregulated programmed death ligand-1 expression on solid tumor cells through the JAK-signal transducer and activator of transcription pathway, and impaired the cytotoxicity of tumor antigen-specific CTL against tumor cells. Following treatment of cells with anti-programmed death ligand-1 mAb after interferon gamma-pre-treatment, the reduced anti-tumor CTL activity by interferon gamma reached a higher level than the non-treatment control targets. In contrast, programmed death ligand-1 expression on tumor cells also significantly correlated with epithelial-mesenchymal transition phenotype in a panel of solid tumor cells. In clinical gastric cancer samples, tumor membrane programmed death ligand-1 expression significantly positively correlated with the presence of CD8-positive T cells in the stroma and interferon gamma expression in the tumor. The results suggest that gastric cancer patients with high CD8-positive T-cell infiltration may be more responsive to anti-programmed death 1/-programmed death ligand-1 mAb therapy.
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance (2008)

This prospective study reports inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance. These associations are potentially important in understanding the etiology of abnormal glucose metabolism and warrant investigation in larger, specifically designed prospective studies and randomized controlled trials of supplementation.
Thalidomide: focus on its employment in rheumatologic diseases. (2003)

Thalidomide is an immunomodulatory agent; although its mechanisms of action are not fully understood, many authors have described its anti-inflammatory and immunosuppressive properties. More interestingly, thalidomide has shown the ability to suppress tumor necrosis factor alpha (TNF alpha) production and to modify the expression of TNF alpha induced adhesion molecules on endothelial cells and on human leukocytes. Thalidomide has been used in several diseases (i.e. dermatological, autoimmune, gastrointestinal). In this review we focus specifically on the use of this drug in disorders with rheumatological features such as lupus erythematosus, rheumatoid arthritis and Still's disease, ankylosing spondylitis, and Behçet's disease. Despite its well known side effects, first of all peripheral nerve involvement and teratogenesis, which can be avoided by following strict guidelines, thalidomide could represent an alternative drug in some rheumatological conditions, particularly in patients who show resistance, contraindication or toxicity with other conventional treatments.
Right‐Sided Endocarditis due to <i>Staphylococcus lugdunensis</i>: First Reported Case (1998)

Staphylococcus lugdunensis is a coagulase-negative organism first identified in 1988. It is often incorrectly identified as Staphylococcus aureus, and has been isolated as the etiological agent in over 20 cases of left-sided endocarditis. This report describes the first documented case of right-sided endocarditis caused by S lugdunensis. This experience suggests that S lugdunensis can infect native valves in the absence of any predisposing risk factors such as injection drug use.
Comparison of stability properties of lactate dehydrogenase B4/ɛ‐crystallin from different species (1993)

epsilon-Crystallin occurs as an abundant lens protein in many birds and in crocodiles and has been identified as heart-type lactate dehydrogenase (LDH-B4). Lens proteins have, due to their longevity and environmental conditions, extraordinary requirements for structural stability. To study lens-protein stability, we compared various parameters of LDH-B4/epsilon-crystallin from lens and/or heart of duck, which has abundant amounts of this enzyme in its lenses, and of chicken and pig, which have no epsilon-crystallin. Measuring the thermostability of LDH-B4 from the different sources, the t50 values (temperature at which 50% of the enzyme activity remains after a 20-min period) for LDH-B4 from duck heart, duck lens and chicken heart were all found to be around 76 degrees C, whereas pig heart LDH-B4 was less thermostable, having a t50 value of 62.5 degrees C. A similar tendency was found with urea inactivation studies. Plotting the first-order rate constants obtained from inactivation kinetic plots against urea concentration, it was clear that LDH-B4 from pig heart was less stable in urea than the homologous enzymes from duck heart, chicken heart and duck lens. The duck and chicken enzymes were also much more resistant against proteolysis than the porcine enzyme. Therefore, it is concluded that avian LDH-B4 is structurally more stable than the homologous enzyme in mammals. This greater stability might make it suitable to function as a crystallin, as in duck, but is not necessarily associated with high lens expression, as in chicken.
A Frequency-Selective Wall for Interference Reduction in Wireless Indoor Environments (2006)

Modifying the indoor wireless physical propagation environment to reduce the interference level was investigated and demonstrated in this research. A common office partition wall (that was in the main propagation path) was transformed into a frequency-selective (FS) wall by attaching a custom-designed band-stop frequency-selective surface (FSS) as a cover on the wall surface. In-situ measurements showed that this frequency-selective wall filtered out signals operating at 5.4-6.0 GHz (IEEE 802.11a) by an additional attenuation of 10-15 dB compared to the unmodified wall, for incident angles ranging from 0deg-55deg in the azimuth plane and 0deg-20deg in the elevation plane. An attenuation of 10-15 dB in signal strength in the stop band is considered to be significant and beneficial in interference reduction, whereas in the pass-band region (such as 1.8 GHz for cellular telephones), signals experienced only marginally more attenuation than that through the unmodified wall. Results also suggest that the interactions between the FSS and the wall surface can be minimized with an appropriate FSS design, which leads to a feasible and practical product solution: frequency-selective wallpapers. In addition, installation issues, such as misalignment of FSS sheets on the wall, were also examined
Architecture Solutions to E-Learning Systems Using Service-Oriented Cloud Computing Reference Architecture (2014)

E-learning systems are moving away from monolithic applications towards more open, flexible components, capable of interoperating with other learning components. In spite of the diversity of learning environments, there is a lack of uniformity regarding their basic functionalities. Thus, the establishment of core functionalities represents an issue to the development of learning environments. In a different but related perspective, reference architectures have emerged as an alternative for promoting reuse of design expertise and facilitating the development of E-learning systems. Reference architecture increases the scalability, flexibility and availability of e-learning systems. The objective of this paper is to provide an architecture solutions to personalized e-learning systems using Service-Oriented Cloud Computing Architecture (SOCCA). SOCCA proposes high level designs to better support multi-tenancy feature of cloud computing The proposed architecture is called namely SOCCAPES, is designed to support maximum scalability and high service levels through virtualization and an optimized management environment. It enables new levels of scalability while providing a very cost-effective modular solution.
DNA Repair Proteins as Molecular Targets for Cancer Therapeutics (2008)

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle and current treatments which typically include radiotherapy, chemotherapy and surgery are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), much less work has focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA which primarily results from the front line cancer treatments; chemotherapy and radiation. More recent studies on a number of DNA repair targets have produced proof-of-concept results showing that selective targeting of these DNA repair enzymes has the potential to enhance and augment the currently used chemotherapeutic agents and radiation as well as overcoming drug resistance. Some of the targets identified result in the development of effective single-agent anti-tumor molecules. While it is inherently convoluted to think that inhibiting DNA repair processes would be a likely approach to kill cancer cells, careful identification of specific DNA repair proteins is increasingly appearing to be a viable approach in the cancer therapeutic cache.
Noise detection during heart sound recording using periodicity signatures (2011)

Heart sound is a valuable biosignal for diagnosis of a large set of cardiac diseases. Ambient and physiological noise interference is one of the most usual and highly probable incidents during heart sound acquisition. It tends to change the morphological characteristics of heart sound that may carry important information for heart disease diagnosis. In this paper, we propose a new method applicable in real time to detect ambient and internal body noises manifested in heart sound during acquisition. The algorithm is developed on the basis of the periodic nature of heart sounds and physiologically inspired criteria. A small segment of uncontaminated heart sound exhibiting periodicity in time as well as in the time-frequency domain is first detected and applied as a reference signal in discriminating noise from the sound. The proposed technique has been tested with a database of heart sounds collected from 71 subjects with several types of heart disease inducing several noises during recording. The achieved average sensitivity and specificity are 95.88% and 97.56%, respectively.
Access Control for Cloud Applications (2015)

In cloud computing, cloud providers store users' data and host users' applications. For many cloud applications, cloud users need to share their data and applications hosted by cloud providers. Many systems use access control mechanisms to secure users' data and applications. This paper proposed an access control scheme for cloud applications. To facilitate resource sharing, the scheme allows cloud users to delegate their access permissions to other users easily. To prevent a third party from inferring knowledge about the cloud users, the scheme uses cryptographic techniques to obscure the access control policies and users' credentials. Data encryption is used to ensure the confidentiality of data. Compared with existing schemes, the proposed scheme is more flexible. Experiments showed that the proposed scheme is also efficient.
Cubic Silsesquioxanes as a Green, High‐Performance Mold Material for Nanoimprint Lithography (2010)

One-step direct nanoimprinting into cubic-silsesquioxane (SSQ) films create low surface energy, high-modulus, thermally stable, and UV-transparent patterns that can then be used as secondary molds for both thermal and UV versions of nanoimprinting. The optimization of these materials is demonstrated by varying the microstructure of the initial SSQ material. The pattern fidelity for features as small as 10 nm is quantified using X-ray reflectivity and AFM.
Etude des Vibrations SN et SO des Dérives de L'acide Imidodisulfurique par Spectrométrie Raman (1982)

Abstract The Raman spectra of sixteen compounds derived from HN(SO 3 ) 2 2− have been compared. The results show that the substitution of one or more of the oxygens of the original tetrahedron SO 4 2− by a ligand F, Cl, NH, N, implies a contraction of the free SO bonds. This is characterized by the shifting of the symmetrical stretching frequency ν s (SO). The polarizing power of the associated cations can also affect ν s (SO).
分析 STAT3 在抗病毒反應中的角色以及 STAT3 的目標基因 (2010)

Type I IFN-stimulation leads to the phosphorylation of STAT1, STAT2, and STAT3. Activated STAT1 and STAT3 can form homodimer or heterodimer. Since STAT1 homodimer, STAT3 homodimer, and STAT1-STAT3 heterodimer can all bind to GAS elements in vitro, it is presumable that the role of STAT1 and STAT3, at least in the type I IFN signaling, is interchangeable. However, genetic studies using knockout mice have revealed that the phenotypes of STAT1KO and STAT3KO mice are very different, suggesting that STAT1 and STAT3 regulate distinct sets of target genes. We have previously shown that in the absence of STAT3, mouse embryonic fibroblasts (MEFs) displayed enhanced expression of ISGs and increased antiviral response upon IFN stimulation and EMCV infection. Here I reported that STAT3 negatively regulated antiviral responses and stimulated type I IFN-dependent STAT1-independent gene expression. First I showed that an enhanced expression of MDA5, an IFN-inducible, cytosolic viral RNA sensor, contributed to the enhanced antiviral response in STAT3KO MEFs. Chromatin immunoprecipitation (ChIP) assays revealed that increased recruitment of ISGF3 on ISRE of MDA5 promoter in STAT3KO MEF following IFN stimulation. Restoration of STAT3 effectively reduced the otherwise increased enrichment of these promoter, suggesting that STAT3 may regulate IFN-induced transactivation by altering the binding or recruitment of ISGF3. Second, by comparing the expression profiles between EV-, STAT1-, STAT3-, and STAT1/STAT3-double-restored MEFs lacking both STAT1 and STAT3, we were able to identify genes dependent on STAT1, STAT3, or both. Chip-seq analysis confirmed that STAT3 bound to the promoters of its target genes. Functional analysis revealed that, by inducing its target genes, STAT3-independently regulated cell migration and antiviral responses. Overall, our results show a negative role of STAT3 in regulating of antiviral responses and a unique role of STAT3 in mediating STAT1-independent gene expression in response to type I IFN.
Efficient Boolean matching algorithm for cell libraries (2002)

An efficient algorithm for searching for functional cells based on Boolean matching in a large library is presented. Redundant variables and permutation of inputs are considered in this algorithm. The algorithm does a search in constant time, independent of the size of the library.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
SWiFT : a feedback control and dynamic reconfiguration toolkit (2018)

Currently, the task of building adaptive system software relies on wizardry. Feedback controls for such software systems are written in an ad-hoc manner and are often brittle. As a result, it is difficult to move an existing control, such as TCP flow control [1], to a new domain such as admission control for CPU scheduling. In addition, existing controls are built with implicit assumptions about the system’s run-time environment and can become unstable in the face of large or discontinuous variations in the environment. We advocate a systematic approach for building adaptive system software based on feedback-control theory. We have implemented the SWiFT toolkit that incorporates this approach. Feedback control helps produce predictable control components. It requires the control goal and design specifications to be clearly stated, thus allowing analysis of properties such as stability. Our approach allows us to leverage the existing body of knowledge in hardware control for controlling software systems. SWiFT allows systematic implementation of feedback-control mechanisms by providing a framework and methodology for building controls that are modular, dynamically reconfigurable, and predictable. Modularity results from our use of components and containers as the underlying abstraction. SWiFT also allows easy dynamic reconfiguration of components by limiting the interaction between components to a simple input/output model and by supporting guarding and replugging of controllers [2]. This reconfiguration allows the application to adapt efficiently across a wide range of operating conditions. SWiFT supports predictability by providing analysis tools based on control theory. Also SWiFT provides GUI debugging tools such as a software oscilloscope and a library of feedback components such as low pass filters to simplify building adaptive system software. We have implemented SWiFT in C++ and Java and we have applied it to user-level applications running on Windows NT. Version 1.0 of SWiFT is available (along with a tutorial) at