gebhart/patrepeval huggingface dataset:
Reaction of nitric oxide with heme proteins: studies on metmyoglobin, opossum methemoglobin, and microperoxidase (1983)

Kinetic and EPR studies show that the first step in the reaction of NO with ferric myoglobin, opossum hemoglobin, and microperoxidase is the reversible formation of the H-NO complex: H + NO in equilibrium H-NO (where H = Mb+, or Hb+ OP, or MP+). The NO-combination rates are markedly affected by the presence or absence of the distal histidine. The distal histidine significantly reduces the NO-combination rates, perhaps by interaction between the distal histidine and the ferric iron. Thus the beta-chains of Hb+ OP and metmyoglobin show similar combination rates. In the absence of a distal histidine, the NO-combination rates in the alpha-chains of Hb+ OP are much faster and similar to those observed for the five-coordinate heme in microperoxidase. The loss of a water molecule from the six-coordination site is assumed to be the rate-limiting step.
Conversion of EEG activity into cursor movement by a brain-computer interface (BCI) (2004)

The Wadsworth electroencephalogram (EEG)-based brain-computer interface (BCI) uses amplitude in mu or beta frequency bands over sensorimotor cortex to control cursor movement. Trained users can move the cursor in one or two dimensions. The primary goal of this research is to provide a new communication and control option for people with severe motor disabilities. Currently, cursor movements in each dimension are determined 10 times/s by an empirically derived linear function of one or two EEG features (i.e., spectral bands from different electrode locations). This study used offline analysis of data collected during system operation to explore methods for improving the accuracy of cursor movement. The data were gathered while users selected among three possible targets by controlling vertical [i.e., one-dimensional (1-D)] cursor movement. The three methods analyzed differ in the dimensionality of the cursor movement [1-D versus two-dimensional (2-D)] and in the type of the underlying function (linear versus nonlinear). We addressed two questions: Which method is best for classification (i.e., to determine from the EEG which target the user wants to hit)? How does the number of EEG features affect the performance of each method? All methods reached their optimal performance with 10-20 features. In offline simulation, the 2-D linear method and the 1-D nonlinear method improved performance significantly over the 1-D linear method. The 1-D linear method did not do so. These offline results suggest that the 1-D nonlinear or the 2-D linear cursor function will improve online operation of the BCI system.
Anion transport heterogeneity detected by flow cytometric measurement of NBD‐taurine efflux kinetics (1984)

NBD-taurine [N-(7-nitrobenzofuran-4-yl) taurine], a fluorescent substrate for the human erythrocyte anion exchange system, has been used to test the feasibility of making flow cytometric measurements of anion transport in K562 erythroleukemic cells. Cells were preloaded by incubation with 20 microM-2mM NBD-taurine, then diluted 10-30-fold, and efflux was monitored by measuring fluorescence intensity (FL) as a function of time using excitation at 488 nm. The observed rate of decrease in fluorescence was sensitive to temperature and also to phloretin, a compound known to inhibit anion transport and other carrier-mediated transport processes. The coefficient of variation (CV) of the fluorescence distribution increased markedly over the efflux period, suggesting heterogeneity of the K562 population with respect to the rate constant for NBD-taurine efflux. This heterogeneity was also reflected in the upward curvature of a first order plot of log (FLt - FL infinity) versus time. Half-times calculated from initial linear portions of the first-order plots were found to decrease as the loading concentration of NBD-taurine was decreased, as predicted for a saturable transport system. NBD-taurine is not an ideal anion transport substrate for flow cytometric studies. It appears to bind to high-affinity sites within the cells with consequent fluorescence quenching, complicating interpretation of kinetic curves at low concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
Acidic butanol removal of color-forming phenols from sunflower meal (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcidic butanol removal of color-forming phenols from sunflower mealGiancarlo Sodini and Marco CanellaCite this: J. Agric. Food Chem. 1977, 25, 4, 822–825Publication Date (Print):July 1, 1977Publication History Published online1 May 2002Published inissue 1 July 1977https://pubs.acs.org/doi/10.1021/jf60212a046https://doi.org/10.1021/jf60212a046research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Percutaneous Transfistulous Interventions for Intractable Pancreatic Fistula (2011)

THREE TECHNIQUES FOR THE TREATMENT OF INTRACTABLE PANCREATIC FISTULA: percutaneous transfistulous pancreatic duct drainage (PTPD), percutaneous transfistulous pancreatojejunostomy (PTPJ), and percutaneous transfistulous pancreatic duct embolization (PTPE) are presented as treatment options for intractable pancreatic fistula. PTPD is effective for most cases of intractable fistula that communicate with the main pancreatic duct. However, PTPD itself is not enough in some specific cases. PTPJ and PTPE are applicable in such cases.
A Grid-Support Strategy With PV Units to Boost Short-Term Voltage Stability Under Asymmetrical Faults (2019)

Modern grid codes demand the integration of voltage support capability with photo-voltaic (PV) generators to ensure a secure operation of power systems. On the other hand, short-term voltage instability (STVI) of distribution networks (DNs) is one of the key issues to be addressed. It can occur due to high proportion of induction motor loads. However, the existing literature lacks a thorough analysis of short-term voltage stability (STVS) of DNs following an asymmetrical fault. Furthermore, an effective voltage-support strategy for PV units, which can improve the STVS while mitigating the excessive voltage swell, is essential for secure operation. Hence, firstly this paper thoroughly investigates the STVS of DNs subjected to asymmetrical faults. It is perceived that voltage support through conventional methods can increase the risk of STVI and excessive voltage swell. Secondly, a new voltage-support strategy is proposed based on the negative sequence voltage at point of common coupling (PCC) aimed at mitigating the STVI and regulating the phase voltages within the margins. The key features of the proposed strategy are, fast and accurate estimation of the network's impedance at PCC is not required and it can be easily re-designed considering the network's dynamic behaviors. The efficacy of the proposed method is validated on two IEEE benchmark test systems, and the results demonstrate the effectiveness in improving the STVS and alleviating over voltage issues.
Implantation of a new device for haemodialysis (2000)

Keywords: arteriovenous shunt; central venous access; further diagnostic revealed thrombotic occlusions of both femoral veins as well as the left iliac vein. In the haemodialysis; iliac vein; implantable device; vascular access right external iliac vein, filling defects were seen by contrast, but the right common iliac vein was found to be patent ( Figure Therefore the right external iliac vein was chosen for the implantation of a subcuta-
Single-Crystal Uniform Tubes of ZnO (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Matrix Metalloproteinase–Targeted Imaging of Lung Inflammation and Remodeling (2016)

Small-animal SPECT/CT-based MMP-targeted imaging of the lungs is feasible and reflects pulmonary inflammation. If validated in humans, molecular imaging of inflammation and remodeling can potentially help early diagnosis and monitoring of the effects of therapeutic interventions in pulmonary diseases.
Improving Dynamic Performance of Stewart Platforms through Optimal Design Based on Evolutionary Multi-objective Optimization Algorithms (2012)

The Stewart platform has characteristics of low natural frequency, antagonistic design objectives and always no analytical expression of both objective functions and constraints which make it difficult to obtain optimum performance with high dynamic performance. Compared with the traditional adopting indices such as manipulability, stiffness, dexterity, accuracy, etc., lowest natural frequency in the total workspace and ratio of maximum and minimum frequencies at typical configurations are developed as dynamic stability and isotropy indices respectively to improve the dynamic performance of Stewart platform. Evolutionary Multi-objective Optimization (EMO) was introduced synthetically considering the dynamic stability index, isotropy index and global dimensionally homogeneous Jacobian matrix condition number. Two typical EMO algorithms are applied for solving the Multi-objective Optimization Problem (MOP), and the algorithms performance was compared. The results are valuable in designing a Stewart platform for well dynamic capability.
A Comparative Analysis of Performance of Shared Memory Cluster Computing Interconnection Systems (2014)

In recent past, many types of shared memory cluster computing interconnection systems have been proposed. Each of these systems has its own advantages and limitations. With the increase in system size of the cluster interconnection systems, the comparative analysis of their various performance measures becomes quite inevitable. The cluster architecture, load balancing, and fault tolerance are some of the important aspects, which need to be addressed. The comparison needs to be made in order to choose the best one for a particular application. In this paper, a detailed comparative study on four important and different classes of shared memory cluster architectures has been made. The systems taken up for the purpose of the study are shared memory clusters, hierarchical shared memory clusters, distributed shared memory clusters, and the virtual distributed shared memory clusters. These clusters are analyzed and compared on the basis of the architecture, load balancing, and fault tolerance aspects. The results of comparison are reported.
Kinetics of murine delayed-type hypersensitivity response to Eimeria falciformis (Apicomplexa: Eimeriidae) (1989)

Mice recovering from a primary infection with an intestinal protozoan parasite, Eimeria falciformis (Apicomplexa: Eimeriidae), showed a classic delayed-type hypersensitivity (DTH) reaction to oocyst antigen challenge. This reaction was characterized by a biphasic pattern of footpad swelling. The first swelling peaked at 2 h after antigen challenge, whereas the second swelling peaked at 24 to 48 h after challenge. The DTH reaction was transferable with a T-cell-enriched spleen cell population from mice that had recovered from E. falciformis infection. Cytotoxic depletion of immune T cells with anti-L3T4 antibody and complement abrogated DTH transfer, indicating that L3T4-positive T cells were required. A T-cell-enriched spleen cell population from acutely infected mice suppressed the transfer of DTH with immune cells from recovered animals, implicating the existence of infection-induced immunoregulatory cells controlling the parasite-specific immune response during infection. Immune spleen cells also transferred resistance to infection as measured by oocyst production and death rate of recipients. Together, these results indicate that the DTH reaction, induced by infection with E. falciformis, is mediated by L3T4-positive T cells and is associated with resistance to infection.
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors (2006)

Sustained cardiac hypertrophy represents one of the most common causes leading to cardiac failure. There is emerging evidence to implicate the involvement of NF-kappaB in the development of cardiac hypertrophy. However, several critical questions remain unanswered. We tested the use of soluble epoxide hydrolase (sEH) inhibitors as a means to enhance the biological activities of epoxyeicosatrienoic acids (EETs) to treat cardiac hypertrophy. sEH catalyzes the conversion of EETs to form the corresponding dihydroxyeicosatrienoic acids. Previous data have suggested that EETs may inhibit the activation of NF-kappaB-mediated gene transcription. We directly demonstrate the beneficial effects of several potent sEH inhibitors (sEHIs) in cardiac hypertrophy. Specifically, we show that sEHIs can prevent the development of cardiac hypertrophy using a murine model of pressure-induced cardiac hypertrophy. In addition, sEHIs reverse the preestablished cardiac hypertrophy caused by chronic pressure overload. We further demonstrate that these compounds potently block the NF-kappaB activation in cardiac myocytes. Moreover, by using in vivo electrophysiologic recordings, our study shows a beneficial effect of the compounds in the prevention of cardiac arrhythmias that occur in association with cardiac hypertrophy. We conclude that the use of sEHIs to increase the level of the endogenous lipid epoxides such as EETs may represent a viable and completely unexplored avenue to reduce cardiac hypertrophy by blocking NF-kappaB activation.
Structure and Photocatalytic Activity of Ti<sub>1-<i>x</i></sub>M<i><sub>x</sub></i>O<sub>2±δ</sub> (M = W, V, Ce, Zr, Fe, and Cu) Synthesized by Solution Combustion Method (2004)

The W, V, Ce, Zr, Fe, and Cu metal ion substituted nanocrystalline anatase TiO2 was prepared by solution combustion method and characterized by XRD, Raman, BET, EPR, XPS, IR TGA, UV absorption, and photoluminescence measurements. The structural studies indicate that the solid solution formation was limited to a narrow range of concentrations of the dopant ions. The photocatalytic degradation of 4-nitrophenol under UV and solar exposure was investigated with Ti1-xMxO2±δ. The degradation rates of 4-nitrophenol with these catalysts were lesser than the degradation rates of 4-nitrophenol with undoped TiO2 both with UV exposure and solar radiation. However, the photocatalytic activities of most metal ion doped TiO2 are higher than the activity of the commercial TiO2, Degussa P25. The decrease in photocatalytic activity is correlated with decrease in photoluminescence due to electron states of metal ions within the band gap of TiO2.
Mosaic-based navigation for autonomous underwater vehicles (2003)

We propose an approach for vision-based navigation of underwater robots that relies on the use of video mosaics of the sea bottom as environmental representations for navigation. We present a methodology for building high-quality video mosaics of the sea bottom in a fully automatic manner, which ensures global spatial coherency. During navigation, a set of efficient visual routines are used for the fast and accurate localization of the underwater vehicle with respect to the mosaic. These visual routines were developed taking into account the operating requirements of real-time position sensing, error bounding, and computational load. A visual servoing controller, based on the vehicle's kinematics, is used to drive the vehicle along a computed trajectory, specified in the mosaic, while maintaining constant altitude. The trajectory toward a goal point is generated online to avoid undefined areas in the mosaic. We have conducted a large set of sea trials, under realistic operating conditions. This paper demonstrates that without resorting to additional sensors, visual information can be used to create environment representations of the sea bottom (mosaics) and support long runs of navigation in a robust manner.
Summer Field Programme of the Victoria Archaeological Survey (1977)

The Summer Field Programme is a special program, which was initiated by the annual Field School for providing a complete range of archaeological courses and lectures to its students. The article discusses the routine, objectives and all the other aspects related to the program.
Intestinal Protein Digestion and Mineral Bioavailability with Special Reference to Casein Phosphopeptide on Ca Absorption (1987)

The solubility of a mineral is a principal criterion for its bioavailability. This property within the small intestinal tract may be markedly affected by a dietary protein source which forms a small amount of macropeptides; the latter interact with minerals having different strength of affinity. Such ligand formation between peptide and mineral cations usually lowers the absorption of minerals. However, in some instances-casein phosphopeptide (CPP) for example-a ligand with cation rather enhances absorption. The relationship in the affinity of mineral ions between ligand and the epithelial mucosal membrane is very important in considering the intestinal mineral absorption.
Siloxane Polymer Films with Varied Microstructures (1989)

Abstract Cross-linked siloxane polymers were prepared by alkali treatment of composite films of CH3Si(OCH3)3 and bilayer-forming amphiphiles. Dissolution of the bilayer matrices gave flexible, free-standing films with varied fine structures.
Quantum Phenomena in Low-Dimensional Systems (2001)

A brief summary of the physics of low-dimensional quantum systems is given. The material should be accessible to advanced physics undergraduate students. References to recent review articles and books are provided when possible.
MTX affects inflammation and tissue destruction differently in the rat AA model. (2001)

Suppression of tissue destruction and inflammation in rat AA does not occur in a concerted fashion as the dose of MTX increases. The implications of these findings to human disease remain to be determined.
Random Subspace Method in Text Categorization (2010)

In text categorization (TC), which is a supervised technique, a feature vector of terms or phrases is usually used to represent the documents. Due to the huge number of terms in even a moderate-size text corpus, high dimensional feature space is an intrinsic problem in TC. Random subspace method (RSM), a technique that divides the feature space to smaller ones each submitted to a (base) classifier (BC) in an ensemble, can be an effective approach to reduce the dimensionality of the feature space. Inspired by a similar research on functional magnetic resonance imaging (fMRI) of brain, here we address the estimation of ensemble parameters, i.e., the ensemble size (L) and the dimensionality of feature subsets (M) by defining three criteria: usability, coverage, and diversity of the ensemble. We will show that relatively medium M and small L yield an ensemble that improves the performance of a single support vector machine, which is considered as the state-of-the-art in TC.
Phosphorylation of Adult Type Sept5 (CDCrel-1) by Cyclin-dependent Kinase 5 Inhibits Interaction with Syntaxin-1 (2007)

Increasing evidence implicates cyclin-dependent kinase 5 (Cdk5) in neuronal synaptic function. We searched for Cdk5 substrates in synaptosomal fractions prepared from mouse brains. Mass spectrometric analysis after two-dimensional SDS-PAGE identified several synaptic proteins phosphorylated by Cdk5-p35; one protein identified was Sept5 (CDCrel-1). Although septins were isolated originally as cell division-related proteins in yeast, Sept5 is expressed predominantly in neurons and is implicated in exocytosis. We confirmed that Sept5 is phosphorylated by Cdk5-p35 in vitro and identified Ser17 of adult type Sept5 (Sept5_v1) as a major phosphorylation site. We found that Ser17 of Sept5_v1 is phosphorylated in mouse brains. Coimmunoprecipitation from synaptosomal fractions and glutathione S-transferase-syntaxin-1A pulldown assays of Sept5_v1 expressed in COS-7 cells showed that phosphorylation of Sept5_v1 by Cdk5-p35 decreases the binding to syntaxin-1. These results indicate that the interaction of Sept5 with syntaxin-1 is regulated by the phosphorylation of Sept5_v1 at Ser17 by Cdk5-p35.
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype (2005)

Nucleophosmin (NPM1) exon-12 gene mutations are the hallmark of a large acute myelogenous leukemia (AML) subgroup with normal karyotype, but their prognostic value in this AML subset has not yet been determined. We screened 401 AML patients with normal karyotype treated within the German AML Cooperative Group Protocol 99 (AMLCG99) study for NPM1 mutations. Results were related with partial tandem duplications within the MLL gene (MLL-PTD), Fms-like tyrosine kinase 3-length mutations (FLT3-LM), the tyrosine kinase domain of FLT3 (FLT3-TKD), NRAS, KIT, and CEBPA mutations and with clinical characteristics and outcome. NPM1 mutations were detected in 212 (52.9%) of 401 patients. Fourteen mutations, including 8 new variants, were identified. NPM1-mutated cases associated frequently with FLT3 mutations but rarely with other mutations. The NPM1-mutated group had a higher complete remission (CR) rate (70.5% vs 54.7%, P = .003), a trend to a longer overall survival (OS; median 1012 vs 549 days, P = .076), and significantly longer event-free survival (EFS; median 428 vs 336 days; P = .012). The favorable impact of NPM1 mutations on OS and EFS clearly emerged in the large group (264 [66.8%] of 395 cases) of normal-karyotype AML without FLT3-LM. This positive effect was lost in the presence of a concomitant FLT3-LM, since survival of the NPM1+/FLT3-LM+ double positive was similar to NPM1-/FLT3-LM+ cases. In conclusion, this study demonstrates that NPM1+/FLT3-LM- mutations are an independent predictor for a favorable outcome in AML with normal karyotype.
EUROPEAN UNION LAW (2010)

This course is designed to provide students with a working knowledge of the legal system of the European Union (“EU”). While the EU is only about half the size of the United States in geographical terms, it is considerably larger than the U.S. in terms of population (500 vs. 300 million). The EU is also the largest economy in the world (based on 2008 IMF data), ahead of both the United States and China. These are not the only reasons to study the EU, but provide one among many reasons for learning about this important example of regional integration.