gebhart/patrepeval huggingface dataset:
Some neuropeptides as modulators of experimental contact allergy (1988)

The rôle of some peptides in allergic contact dermatitis was investigated. The neuropeptides: substance P (SP), vasoactive intestinal peptide (VIP) and somatostatin, as well as the SP antagonist spantide, were injected into the same skin sites as the antigen in patients with contact allergy to nickel. The neuropeptides did not influence the eczematous reaction but spantide diminished it. This might speak for a pathogenetic rôle of SP in allergic contact dermatitis.
A Substrate Integrated Cavity Backed Filtering Slot Antenna Stacked With a Patch for Frequency Selectivity Enhancement (2018)

A patch is proposed to stack above a substrate integrated cavity (SIC) backed filtering slot antenna to enhance antenna frequency selectivity. The antenna is composed of a slot radiator backed by an SIC, a stacked patch, and a microstrip feed line. Two parallel slots are cut onto the top broad wall of the SIC, which is excited by a microstrip line through a nonresonant short slot on the center of the bottom broad wall. The stacked patch is positioned right above the SIC supported by a piece of substrate slab for gain enhancement. Compared with the traditional SIC-backed slot antenna, the proposed antenna achieves higher frequency selectivity as well as enhanced bandwidth and gain. The field distribution and parametric study are conducted to exhibit the operating mechanism of the antenna more clearly. Compared with the conventional SIC-backed slot antenna, the antenna prototype operating at 10 GHz, as example, achieves wider 10 dB impedance matching bandwidth of 8.67%, higher gain of 7.2 dBi, better frequency selectivity of 0.9/0.45 at the lower and upper edges of the operation band, and lower maximum cross-polarization levels of -23/-22 dB in E- and H-planes within the 3 dB beam range, respectively.
Selective MicroRNA Suppression in Human Thoracic Aneurysms (2011)

These findings demonstrate altered miR expression patterns in clinical TAA specimens, suggesting that the loss of specific miR expression may allow for the elaboration of specific MMPs capable of driving aortic remodeling during TAA development. Importantly, these data suggest that these miRs have biological and clinical relevance to the behavior of TAAs and may provide significant targets for therapeutic and diagnostic applications.
Three Simultaneous Major Sleep Disorders (1987)

A patient with complex symptomatology is described. Progress in the diagnosis of sleep disorders gradually led to successful diagnosis-based treatment.
Effects of EGF, BFGF, NGF and PDGF(bb) on cell proliferative, migratory and invasive capacities of human brain‐tumour biopsies <i>In Vitro</i> (1993)

Spheroids initiated directly from human primary gliomas were used to investigate the effects of EGF, bFGF, NGF and PDGF(bb) on cell proliferation, migration and invasion into foetal rat brain tissue. EGF increased tumour spheroid volume in 10 of 13 glioblastomas studied, whereas 5 of 11 tumours responded to bFGF. NGF increased the spheroid volume in 2 of 5 tumours. In 8 tumours, PDGF(bb) had no effect on tumour spheroid volume. An increase in BUdR-labelling indices confirmed that cell proliferation was responsible for the volume increase observed in stimulated spheroids. EGF stimulated cell migration in 5 and bFGF in 3 of 8 tumours studied. NGF stimulated cell migration in 1 of 5 glioblastomas, whereas 1 of 3 glioblastomas responded to PDGF(bb). The effects of growth factors on the invasion of spheroids prepared from the glioblastoma biopsy specimens were also studied in vitro using foetal rat brain aggregates as target tissue. EGF stimulated invasion in 7 of 8 glioblastomas studied, whereas bFGF stimulated invasion in 2 of these tumours. NGF or PDGF(bb) did not increase the invasiveness of the glioblastoma tissue. Our results represent the net effect of the growth factors on a complex tumour-cell population. We conclude that exogenously administered growth factors, EGF in particular, increase the cell proliferation as well as migratory and invasive capacities of cultured primary brain tumour biopsies in vitro.
Triatominae Survey (Hemiptera: Reduviidae: Triatominae) in the South-Central Region of the State of Bahia, Brazil Between 2008 and 2013 (2015)

Triatomine surveillance in rural areas, artificial ecotypes, and natural ecotopes of the cities of Caturama, Ibipitanga, Macaúbas, and Seabra in the south-central region of the Brazilian state of Bahia was carried out between 2008 and 2013. Natural infection by Trypanosoma cruzi was evaluated in the specimens collected to monitor vectors of Chagas disease. A total of 1,357 specimens were collected, and four species were identified: Triatoma sordida (83%), Triatoma lenti (16.4%), Triatoma pseudomaculata (0.5%), and Panstrongylus geniculatus (0.1%). Triatoma sordida was found in four cities, only 0.7% in intradomiciliary environments. Triatoma lenti was found only in Macaúbas; 8.5% were found in intradomiciliary environments, 88.3% in peridomiciliary environments, and 3.1% in sylvatic environments. Natural infection by T. cruzi was 0.5% for T. sordida and 3.1% T. lenti. All of these cases were found in peridomiciliary environments of Macaúbas. As the results show, triatomines were found in intradomiciliary environments in three cities that were surveyed in the south-central region of the state of Bahia. Thus, an epidemiologic survey should be performed to avoid the risk of transmission to the population.
Learning Object Interactions and Descriptions for Semantic Image Segmentation (2017)

Recent advanced deep convolutional networks (CNNs) achieved great successes in many computer vision tasks, because of their compelling learning complexity and the presences of large-scale labeled data. However, as obtaining per-pixel annotations is expensive, performances of CNNs in semantic image segmentation are not fully exploited. This work significantly increases segmentation accuracy of CNNs by learning from an Image Descriptions in the Wild (IDW) dataset. Unlike previous image captioning datasets, where captions were manually and densely annotated, images and their descriptions in IDW are automatically downloaded from Internet without any manual cleaning and refinement. An IDW-CNN is proposed to jointly train IDW and existing image segmentation dataset such as Pascal VOC 2012 (VOC). It has two appealing properties. First, knowledge from different datasets can be fully explored and transferred from each other to improve performance. Second, segmentation accuracy in VOC can be constantly increased when selecting more data from IDW. Extensive experiments demonstrate the effectiveness and scalability of IDW-CNN, which outperforms existing best-performing system by 12% on VOC12 test set.
A multi-carrier amplifier for future mobile communications systems (1991)

The goal of dynamic channel allocation has eluded cellular system designers and operators alike since the concept of cellular mobile communications first became a reality. The idea of virtually instantaneous frequency re-planning of selected parts (or even all) of a cellular network has obvious attractions and alone would justify the considerable efforts being invested by a number of organisations towards this goal. The achievement of this flexibility would either require the use of remotely tunable combiners or of a broadband, highly linear power amplifier. The former option is unlikely ever to achieve the total flexibility promised by the use of a linear amplifier and hence this latter field has been the subject of considerable recent interest. >
Carbon Nanotube/Space Durable Polymer Nanocomposite Films for Electrostatic Charge Dissipation (2002)

Low solar absorptivity, space environmentally stable polymeric materials possessing sufficient electrical conductivity for electrostatic charge dissipation (ESD) are of interest for potential applications on spacecraft as thin film membranes on antennas, solar sails, large lightweight space optics, and second surface mirrors. One method of imparting electrical conductivity while maintaining low solar absorptivity is through the use of single wall carbon nanotubes (SWNTs). However, SWNTs are difficult to disperse. Several preparative methods were employed to disperse SWNTs into the polymer matrix. Several examples possessed electrical conductivity sufficient for ESD. The chemistry, physical, and mechanical properties of the nanocomposite films will be presented.
Effects of glycosylation on the conformation and dynamics of O-linked glycoproteins: carbon-13 NMR studies of ovine submaxillary mucin (1989)

Carbon-13 NMR spectroscopic studies of native and sequentially deglycosylated ovine submaxillary mucin (OSM) have been performed to examine the effects of glycosylation on the conformation and dynamics of the peptide core of O-linked glycoproteins. OSM is a large nonglobular glycoprotein in which nearly one-third of the amino acid residues are Ser and Thr which are glycosylated by the alpha-Neu-NAc(2-6)alpha-GalNAc- disaccharide. The beta-carbon resonances of glycosylated Ser and Thr residues in intact and asialo mucin display considerable chemical shift heterogeneity which, upon the complete removal of carbohydrate, coalesces to single sharp resonances. This chemical shift heterogeneity is due to peptide sequence variability and is proposed to reflect the presence of sequence-dependent conformations of the peptide core. These different conformations are thought to be determined by steric interactions of the GalNAc residue with adjacent peptide residues. The absence of chemical shift heterogeneity in apo mucin is taken to indicate a loss in the peptide-carbohydrate steric interactions, consistent with a more relaxed random coiled structure. On the basis of the 13C relaxation behavior (T1 and NOE) the dynamics of the alpha-carbons appear to be unique to each amino acid type and glycosylation state, with alpha-carbon mobilities decreasing in the order Gly greater than Ala = Ser greater than Thr much greater than monoglycosylated Ser/Thr approximately greater than disaccharide linked Ser/Thr.(ABSTRACT TRUNCATED AT 250 WORDS)
Displaying Random Surfaces (1987)

This paper presents some techniques for simplifying the display of random surfaces created by a regular facet-evolution method similar to that which we described in an earlier paper.1 We concentrate on the problems of hidden surface elimination and shadowing, and show how these can be handled in a way that achieves economy of storage whilst avoiding program complexity. The techniques presented are image space ones, and the emphasis is on producing realistic looking pictures rather than achieving strict mathematical accuracy.
TRP Channels and Pain (2009)

Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs". We detect a wide range of noxious stimuli via a limited number (as of today, six) of thermoTRP channels, four of which (TRPV1-TRPV4) respond to heat and two (TRPA1 and TRPM8) are sensitive to cold. Targeting these thermoTRP channels represents a new and logical strategy in pain relief. Unlike traditional analgesic drugs that either suppress inflammation (e.g. NSAIDs and COX-2 inhibitors) or block pain transmission (e.g. opiates), TRP channel inhibitors aim to prevent pain by blocking a receptor where pain is generated. The archetypal thermoTRP is the vanilloid (capsaicin) receptor TRPV1. TRPV1 has a dynamic threshold of activation. Agents in inflammatory soup, including endogenous TRPV1 agonists (so-called "endovanilloids"), act in concert to reduce the heat activation threshold of TRPV1. In patients, the expression of TRPV1 is up-regulated in a number of painful inflammatory disorders. TRPV1 as a pain target has been validated by genetic deletion and pharmacological inhibition experiments. This area of drug development has been moving rapidly. It took less than a decade from the cloning of TRPV1 to clinical trials with potent small molecule TRPV1 antagonists. This review evaluates current evidence that supports particular TRP channels as targets for novel analgesic drugs, along with potential adverse effects that may limit drug development.
Design and performance evaluation of a cache assist to implement selective caching (1997)

Conventional cache architectures exploit locality, but do so rather blindly. By forcing all references through a single structure, the cache's effectiveness on many references is reduced. This paper presents a cache assist namely the annex cache which implements a selective caching scheme. Except for filling a main cache at cold start, all entries come to the cache via the annex cache. Items referenced only rarely will be excluded from the main cache, eliminating several conflict misses. The basic premise is that an item deserves to be in the main cache only if it can prove its right to exist in the main cache by demonstrating locality. The annex cache combines the features of Jouppi's (1990) victim caches and McFarling's (1992) cache exclusion schemes. Extensive simulation studies for annex and victim caches using a variety of SPEC programs are presented in the paper. Annex caches were observed to be significantly better than conventional caches, better than victim caches in certain cases, and comparable to victim caches in other cases.
Low-Energy Electron Exposure of Space Materials (2011)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Even Faster Hashing on the Pentium (1997)

. In this short note we presentanimprovementofabout15%over our performance figures for the MD4-family of hash functions as presented at Crypto&apos;96. The improvement is obtained by substituting n-cycle instructions by n 1-cycle instructions, and reducing the number of instructions by means of the super-add instruction lea, thereby carefully avoiding the dreaded AGI. In [BGV96]we presented optimized implementations of MD4, MD5, SHA-1, RIPEMD, RIPEMD-128 and RIPEMD-160 on Intel&apos;s Pentium processor. The goal of this short note is to present an improvement of about 15% over these figures. We refer to [BGV96] for an explanation of the terminology used, and to [BGV97] for a detailed critical path analysis of these algorithms. In terms of processor pipeline stages the critical path of these new implementations is slightly longer (on the average about 16 stages). However, this lengthening allows us to substitute the single remaining 2-cycle instruction in eachstepby 2 single cycle instructions. T...
Synthesis and Anticonvulsant Activity of Certain Substituted Furochromone, Benzofuran and Flavone Derivatives (2010)

Synthesis of furochromone, 2-phenylchromone (flavone) and benzofuran derivatives substituted with thiosemicarbazide or thiazolidin-4-one moieties were accomplished. All the newly synthesized compounds were tested for their anticonvulsant activity in both subcutaneous pentylenetetrazole induced seizures (scPTZ) and maximal electric shock induced seizures (MES) tests using valproic acid and phenytoin respectively as reference standards. The most active compounds in scPTZ model were 1c, 2b, 5a and 7e showing 100% protection at 300 mg/kg upon intraperitoneal administration. Also, the effect of pre-treatment of three of the most active compounds (1c, 2b, 5a) on 4-amino pyridine-induced lethality in mice was investigated. Pre-treatment with these compounds significantly increased the latency for clonic and tonic seizures and prevented 4-amino pyridine induced death. Hence, this provides evidence for anticonvulsant activity of these compounds, and a neuroprotective activity for them. The structure-activity relationship was studied based on the obtained data.
A Multiple Reaction Monitoring (MRM) Method to Detect Bcr-Abl Kinase Activity in CML Using a Peptide Biosensor (2013)

The protein kinase Bcr-Abl plays a major role in the pathogenesis of chronic myelogenous leukemia (CML), and is the target of the breakthrough drug imatinib (Gleevec™). While most patients respond well to imatinib, approximately 30% never achieve remission or develop resistance within 1-5 years of starting imatinib treatment. Evidence from clinical studies suggests that achieving at least 50% inhibition of a patient's Bcr-Abl kinase activity (relative to their level at diagnosis) is associated with improved patient outcomes, including reduced occurrence of resistance and longer maintenance of remission. Accordingly, sensitive assays for detecting Bcr-Abl kinase activity compatible with small amounts of patient material are desirable as potential companion diagnostics for imatinib. Here we report the detection of Bcr-Abl activity and inhibition by imatinib in the human CML cell line K562 using a cell-penetrating peptide biosensor and multiple reaction monitoring (MRM) on a triple quadrupole mass spectrometer. MRM enabled reproducible, selective detection of the peptide biosensor at fmol levels from aliquots of cell lysate equivalent to ~15,000 cells. This degree of sensitivity will facilitate the miniaturization of the entire assay procedure down to cell numbers approaching 15,000, making it practical for translational applications in patient cells in which the limited amount of available patient material often presents a major challenge.
Expression of Human α-Tubulin Genes: Interspecies Conservation of 3′ Untranslated Regions (1983)

To examine the sequence complexity and differential expression of human alpha-tubulin genes, we constructed cDNA libraries from two unrelated tissue types (epidermis and fetal brain). The complete sequence of a positively hybridizing alpha-tubulin clone from each library is described. Each is shown to represent an abundantly expressed gene from fetal brain and keratinocytes, respectively. Although the coding regions are extensively homologous (97%), the 3' untranslated regions are totally dissimilar. This property has been used to dissect the human alpha-tubulin multigene family into members bearing sequence relatedness in this region. Surprisingly, each of these noncoding regions shares very high (65 to 80%) interspecies homology with the 3' untranslated region of one of the two rat alpha-tubulin genes of known sequence. These unexpected homologies imply the existence of selective pressure on the 3' untranslated regions of some cytoskeletal genes which maintains sequence fidelity during the course of evolution, perhaps as a consequence of an as yet unidentified functional requirement.
The Plate Tectonics Project (2011)

ABSTRACT The Plate Tectonics Project is a multiday, inquiry-based unit that facilitates students as self-motivated learners. Reliable Web sites are offered to assist with lessons, and a summative rubric is used to facilitate the holistic nature of the project. After each topic (parts of the Earth, continental drift, etc.) is covered, the students will generate a portion of the summative assessment that will be set aside and later compiled into a booklet. This summative assessment creates the circumstance in which each student must develop literacy and organizational skills to master the concept that the Earth is a global, dynamic, lithospheric system.
Megalin and Cubilin are Endocytic Receptors Involved in Renal Clearance of Hemoglobin (2002)

ABSTRACT. The kidney is the main site of hemoglobin clearance and degradation in conditions of severe hemolysis. Herein it is reported that megalin and cubilin, two epithelial endocytic receptors, mediate the uptake of hemoglobin in renal proximal tubules. Both receptors were purified by use of hemoglobin-Sepharose affinity chromatography of solubilized renal brush-border membranes. Apparent dissociation constants of 1.7 μM for megalin and 4.1 μM for cubilin were determined by surface plasmon resonance analysis. The binding was calcium dependent in both cases. Uptake of fluorescence-labeled hemoglobin by BN-16 cells was inhibited by anti-megalin and anti-cubilin antibodies as well as by receptor-associated protein, a chaperone for LDL-receptor family proteins. Partial inhibition by myoglobin was observed, whereas bovine serum albumin, intrinsic factor-cobalamin complexes, and β2-microglobulin did not affect the uptake. By use of immunohistochemistry, it was demonstrated that uptake of hemoglobin in proximal tubules of rat, mouse, and dog kidneys occurs under physiologic conditions. Studies on normal and megalin knockout mouse kidney sections showed that megalin is responsible for physiologic clearance of hemoglobin. Labeling intensities in kidneys from normal and cubilin-malexpressing dogs were similar, which suggests that, in the normal state, the role of cubilin in uptake of hemoglobin is rather limited. However, cubilin is likely to assist hemoglobin endocytosis in settings of hemoglobinuria. In conclusion, the study provides a molecular explanation for long-standing observations of hemoglobin uptake in renal proximal tubules that involve the endocytic receptors megalin and cubilin. The findings may prove to be essential for further research on the pathophysiology of hemoglobinuric acute renal failure and proteinuria-associated tubulointerstitial nephritis.
Hepatocellular Carcinoma Associated with Liver-Gender Disruption in Male Mice (2007)

Hepatocellular carcinoma (HCC) is a male-predominant cancer associated with chronic hepatitis. Like human viral hepatitis, murine Helicobacter hepaticus infection produces inflammation and HCC with a masculine bias. We used this model to identify potential mechanisms of male HCC predisposition. Male weanling A/JCr mice (n = 67) were gavaged with H. hepaticus or vehicle. At 1 year, mice were distributed into four groups: surgical castration, chemical castration, castration followed by dihydrotestosterone supplementation, or sexually intact controls. Responses to infection were compared with IFN-gamma challenge alone. At 21 months, there was no significant difference in hepatitis between groups. Neither castration nor androgen receptor agonism altered tumor incidence. Infected mice with severe, but not mild, disease exhibited a mosaic of alterations to sexually dimorphic genes and microsomal long-chain fatty acids. By microarray, tumorigenic hepatitis was strongly associated with liver-gender disruption, defined as the loss of a gender-identifying hepatic molecular signature. IFN-gamma alone produced similar changes, demonstrating a role for proinflammatory cytokines in this process. In conclusion, hepatocarcinogenesis in male mice with chronic hepatitis is maturationally imprinted and androgen-independent. Proinflammatory cytokines may promote HCC in a male-predominant fashion due to high sensitivity of the masculinized liver to loss of sex-specific transcriptional balance. Liver-gender disruption has pleiotropic implications for hepatic enzyme activity, lipid processing, nuclear receptor activation, apoptosis, and proliferation. We propose a multistep model linking chronic hepatitis to liver cancer through cytokine-mediated derangement of gender-specific cellular metabolism. This model introduces a novel mechanism of inflammation-associated carcinogenesis consistent with male-predominant HCC risk.