gebhart/patrepeval huggingface dataset:
Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go? (2019)

Voltage-gated sodium (Nav) channels are critical players in the generation and propagation of action potentials by triggering membrane depolarization. Mutations in Nav channels are associated with a variety of channelopathies, which makes them relevant targets for pharmaceutical intervention. So far, the cryoelectron microscopic structure of the human Nav1.2, Nav1.4, and Nav1.7 has been reported, which sheds light on the molecular basis of functional mechanism of Nav channels and provides a path toward structure-based drug discovery. In this review, we focus on the recent advances in the structure, molecular mechanism and modulation of Nav channels, and state updated sodium channel blockers for the treatment of pathophysiology disorders and briefly discuss where the blockers may be developed in the future.
Photophysical and Morphological Implications of Single-Strand Conjugated Polymer Folding in Solution (2016)

Organic semiconductors have garnered substantial interest in optoelectronics, but their device performances exhibit strong dependencies on material crystallinity and packing. In an effort to understand the interactions dictating the morphological and photophysical properties of a high-performing photovoltaic polymer, PTB7, a series of short oligomers and low molecular weight polymers of PTB7 were synthesized. Chain-length dependent optical studies of these oligomers demonstrate that PTB7’s low-energy visible absorption is largely due to self-aggregation-induced ordering, rather than in-chain charge transfer, as previously thought. By examining molecular weight and concentration dependent optical properties, supplemented by molecular dynamics simulations, we attribute polymeric PTB7’s unique midgap fluorescence and concentration independent absorption spectrum to an interplay between low molecular weight unaggregated strands and high-molecular weight self-aggregated (folded) strands. Specifically, we propose that the onset of PTB7 self-folding occurs between 7 and 13 repeat units, but the aggregates characteristic of polymeric PTB7 only develop at lengths of ∼30 repeat units. Atomistic molecular dynamics simulations of PTB7 corroborate these conclusions, and a simple relation is proposed which quantifies the free-energy of conjugated polymer folding. This study provides detailed guidance in the design of intra- and interchain contributions to the photophysical and morphological properties of polymeric semiconductors.
FAULTFINDER: A DIAGNOSTIC EXPERT SYSTEM WITH GRACEFUL DEGRADATION FOR ONBOARD AIRCRAFT APPLICATIONS (1988)

A research effort was conducted to explore the application of artificial intelligence technology to automation of fault monitoring and diagnosis as an aid to the flight crew. Human diagnostic reasoning was analyzed and actual accident and incident cases were reconstructed. Based on this analysis and reconstruction, diagnostic concepts were conceived and implemented for an aircraft's engine and hydraulic subsystems. These concepts are embedded within a multistage approach to diagnosis that reasons about time-based, causal, and qualitative information, and enables a certain amount of graceful degradation. The diagnostic concepts are implemented in a computer program called Faultfinder that serves as a research prototype.
Design and simulation of air compressor performance controller (2010)

The shock losses of the impeller and the diffuser will increase when the Centrifugal compressor is not running under the Specified operation point. For the compressor system is time-varying, nonlinear, strong coupling, hysteresis, model instability characteristics, the Fuzzy-PID controller is designed. The result of MATLAB simulation shows that response of the system is small overshoot, short dynamic process. The controller will ensure the compressor system running under the Specified operation point so as to avoid the shock loss. According to the running state of the centrifugal compressor 32000 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> /h, Quantitative analysis of the energy saving is made after using the fuzzy PID controller.
Live forensics (2006)

Live forensics gathers data from running systems, providing additional contextual information that is not available in a disk-only forensic analysis.
A Minimalist Substrate for Enzymatic Peptide and Protein Conjugation (2009)

Recently a number of nonnatural prenyl groups containing alkynes and azides have been developed as handles to perform click chemistry on proteins and peptides ending in the sequence "CAAX", where C is a cysteine that becomes alkylated, A is an aliphatic amino acid and X is any amino acid. When such molecules are modified, a tag containing a prenyl analogue and the "CAAX box" sequence remains. Here we report the synthesis of an alkyne-containing substrate comprised of only nine nonhydrogen atoms. This substrate was synthesized in six steps from 3-methylbut-2-en-1-ol and has been enzymatically incorporated into both proteins and peptides by using protein farnesyltransferase. After prenylation the final three amino acids required for enzymatic recognition can be removed by using carboxypeptidase Y, leaving a single residue (the cysteine from the "CAAX box") and the prenyl analogue as the only modifications. We also demonstrate that this small tag minimizes the impact of the modification on the solubility of the targeted protein. Hence, this new approach should be useful for applications in which the presence of a large tag hinders the modified protein's solubility, reactivity, or utility.
Cargo Container Insert Program. (1979)

The cargo container insert program conducted by MERADCOM was initiated in fiscal year 1976 to identify characteristics for a container insert. Basic requirements included 4000-pound-capacity, weather-resistant, lightweight, and reusable features. The program involved a survey of both commercial manufacturers and Military users. One prototype insert type was procured and tested prior to program termination. (Author)
Program understanding and the concept assignment problem (1994)

article Free Access Share on Program understanding and the concept assignment problem Authors: Ted J. Biggerstaff Microsoft Research, Redmond, WA Microsoft Research, Redmond, WAView Profile , Bharat G. Mitbander Microelectronics and Computer Technology Corp. (MCC), Austin, TX Microelectronics and Computer Technology Corp. (MCC), Austin, TXView Profile , Dallas E. Webster Microelectronics and Computer Technology Corp. (MCC), Austin, TX Microelectronics and Computer Technology Corp. (MCC), Austin, TXView Profile Authors Info & Claims Communications of the ACMVolume 37Issue 5May 1994pp 72–82https://doi.org/10.1145/175290.175300Published:01 May 1994Publication History 250citation1,578DownloadsMetricsTotal Citations250Total Downloads1,578Last 12 Months35Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Response of Melon Fly (Diptera: Tephritidae) to Weathered SPLAT-Spinosad-Cue-Lure (2010)

Studies were conducted in Hawaii to measure attraction of male melon fly, Bactrocera cucurbitae (Coquillett) (Diptera: Tephritidae), to SPLAT-Cue-Lure (C-L) and SPLAT-Melo-Lure (M-L) (raspberry ketone formate). Direct field comparisons of SPLAT-C-L and SPLAT-M-L at low (5%) and high (20%) concentrations indicated few differences in attraction over a 15-wk period. Subsequently, only SPLAT-Spinosad-C-L (5%) was compared with Min-U-Gel C-L with naled (standard used in California) in weathering studies. Treatments were weathered for 1, 2, 4, and 8 wk in Riverside, CA, and shipped to Hawaii for attraction/toxicity tests under field and semifield conditions by using released males of controlled ages, and for feeding tests in the laboratory. In terms of attraction, SPLAT-Spinosad-C-L compared favorably to, or outperformed the current standard of Min-U-Gel-C-L with naled. In terms of toxicity, the cumulative 24-h mortality did not differ between the two insecticide-containing C-L treatments in field cage studies after 8 wk. However, in feeding studies in which individual males were exposed for 5 min to the different C-L treatments after 4 wk of weathering, SPLAT-Spinosad-C-L demonstrated reduced mortality compared with the Min-U-Gel-C-L with naled, suggesting reduced persistence of the spinosad material. Spinosad has low contact toxicity and when mixed with SPLAT and C-L offers a reduced risk alternative for control of B. cucurbitae and related C-L-responding species, without many of the negative effects to humans and nontargets of broad-spectrum contact poisons such as naled.
A Novel Polypeptide Derived From Human Lactoferrin in Sodium Hyaluronate Prevents Postsurgical Adhesion Formation in the Rat (2009)

A new class of synthetically derived water soluble low molecular weight peptide compound, PXL01 showed marked reduction of peritoneal adhesion formation in an animal model without any negative effects on healing. On the basis of these data, a comprehensive adhesion prevention regimen in clinical situation is expected.
Room Temperature Cyclopentadiene Elimination Reaction for the Synthesis of Diethylgallium−Amides, −Phosphides, and −Thiolates. Crystal and Molecular Structures of [Et<sub>2</sub>GaP(t-Bu)<sub>2</sub>]<sub>2</sub> and [Et<sub>2</sub>GaS(SiPh<sub>3</sub>)]<sub>2</sub> (1996)

The compounds [Et2GaNEt2]2, [Et2GaN(H)(Me)]2, [Et2GaN(H)(t-Bu)]2, [Et2GaP(i-Pr)2]2, [Et2GaP(t-Bu)2]2, and [Et2GaS(SiPh3)]2 have been prepared in high yields at room temperature by the elimination of cyclopentadiene from Et2Ga(C5H5) and the corresponding amine, phosphine, or thiol. The three diethylgallium amides and [Et2GaP(i-Pr)2]2 are liquids, whereas the other phosphide and the thiolate are crystalline solids at room temperature. All compounds were fully characterized by elemental analyses, 1H and 31P NMR spectroscopy, and cryoscopic molecular weight studies in benzene, as appropriate, and are dimeric in solution. The crystalline compounds [Et2GaP(t-Bu)2]2, and [Et2GaS(SiPh3)]2 were characterized by X-ray structural studies. Even though [Et2GaN(H)(t-Bu)]2 and [Et2GaS(SiPh3)]2 were prepared at room temperature and isolated in high yield, 1H NMR studies revealed that neither compound was formed in high yield in solution. Removal of the cyclopentadiene by either dimerization or distillation and/or dimerization of the gallium product are necessary to prevent the back-reaction to re-form the reactants.
The Carpenters: the untold story: an authorized biography (1994)

Music journalist Coleman, the author of Lennon and Clapton!, with the full cooperation of Richard and the Carpenter famiy, explores the public and private lives of the Carpenters, portraying Richard and Karen's dynamic pop music career as well as Karen's descent into anorexia nervosa and untimely death. 32 pages of photos.
Practice Parameters for Using Polysomnography to Evaluate Insomnia: An Update (2003)

Insomnia is a common and clinically important problem. It may arise directly from a sleep-wake regulatory dysfunction and/or indirectly result from comorbid psychiatric, behavioral, medical, or neurological conditions. As an important public-health problem, insomnia requires accurate diagnosis and effective treatment. Insomnia is primarily diagnosed clinically with a detailed medical, psychiatric, and sleep history. Polysomnography is indicated when a sleep-related breathing disorder or periodic limb movement disorder is suspected, initial diagnosis is uncertain, treatment fails, or precipitous arousals occur with violent or injurious behavior. However, polysomnography is not indicated for the routine evaluation of transient insomnia, chronic insomnia, or insomnia associated with psychiatric disorders.
Heterogeneous Gold-Based Catalysis for Green Chemistry:  Low-Temperature CO Oxidation and Propene Oxidation (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHeterogeneous Gold-Based Catalysis for Green Chemistry: Low-Temperature CO Oxidation and Propene OxidationByoung Koun Min and Cynthia M. FriendView Author Information Department of Chemistry and Chemical Biology and Division of Engineering and Applied Sciences, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Cite this: Chem. Rev. 2007, 107, 6, 2709–2724Publication Date (Web):June 13, 2007Publication History Received17 August 2006Published online13 June 2007Published inissue 1 June 2007https://pubs.acs.org/doi/10.1021/cr050954dhttps://doi.org/10.1021/cr050954dresearch-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views11009Altmetric-Citations703LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Gold,Oxidation,Oxides,Oxygen Get e-Alerts
Highly Luminescent 2D‐Type Slab Crystals Based on a Molecular Charge‐Transfer Complex as Promising Organic Light‐Emitting Transistor Materials (2017)

A new 2:1 donor (D):acceptor (A) mixed-stacked charge-transfer (CT) cocrystal comprising isometrically structured dicyanodistyrylbenzene-based D and A molecules is designed and synthesized. Uniform 2D-type morphology is manifested by the exquisite interplay of intermolecular interactions. In addition to its appealing structural features, unique optoelectronic properties are unveiled. Exceptionally high photoluminescence quantum yield (Φ<sub>F</sub> ≈ 60%) is realized by non-negligible oscillator strength of the S<sub>1</sub> transition, and rigidified 2D-type structure. Moreover, this luminescent 2D-type CT crystal exhibits balanced ambipolar transport (µ<sub>h</sub> and µ<sub>e</sub> of ≈10<sup>-4</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> ). As a consequence of such unique optoelectronic characteristics, the first CT electroluminescence is demonstrated in a single active-layered organic light-emitting transistor (OLET) device. The external quantum efficiency of this OLET is as high as 1.5% to suggest a promising potential of luminescent mixed-stacked CT cocrystals in OLET applications.
Microstrip-Fed 3-D Folded Slot Antenna on Cubic Structure (2015)

A 3-D cube antenna with application in wireless sensor network is presented in this letter. Employing microstrip-fed 3-D folded slot antenna topology, a horizontally polarized omnidirectional radiation pattern in azimuth plane was obtained. The structure that is compatible with 3-D printing was fabricated from RO3003 substrate and Objet VeroGray material. The interior of the cubic structure can be used to place electronic circuits of transceiver and sensor. Measurement results verify simulation, and a maximum gain of 1.95 dBi in the azimuth plane and bandwidth of 14% at the center frequency of 2.495 GHz were achieved. The cubic antenna has an edge length of 33 mm and covers the ISM 2.45-GHz frequency band, which has vast application in wireless sensor networks and telecommunication devices.
Procurement and Renegotiation (1986)

Parties bound by an incomplete contract have an incentive to renegotiate after acquiring new information. The issue of the parties' investment in the relationship before renegotiation is analyzed in a simple two-period procurement model. The firm invests in the first period. It then learns its production cost, and the sponsor learns its value for the project. Williamson's underinvestment presumption is shown to hold under very general assumptions about bargaining and about the ex post asymmetry of information as long as the firm's investment is not observable by the sponsor. The introduction of a cancellation fee may well lead to even less investment contrary to what is sometimes argued. The role of ex ante price fixing as an alternative way to reintroduce some form of commitment and the problem of cost overruns are discussed. Last, it is shown that if investment is observable by the sponsor andthus may become a joint decision variable, the two parties may choose to under- or overinvest.
Parametric Study of Fuel Cell and Gas Turbine Combined Cycle Performance (1997)

A number of cycles have been proposed in which a solid oxide fuel cell is used as the topping cycle to a gas turbine, including those recently described by Beve et al. (1996). Such proposals frequently focus on the combination of particular gas turbines with particular fuel cells. In this paper, the development of more general models for a number of alternative cycles is described. These models incorporate variations of component performance with key cycle parameters such as gas turbine pressure ratio, fuel cell operating temperature and air flow. Parametric studies are conducted using these models to produce performance maps, giving overall cycle performance in terms of both gas turbine and fuel cell design point operating conditions. The location of potential gas turbine and fuel cell combinations on these maps is then used to identify which of these combinations are most likely to be appropriate for optimum efficiency and power output. It is well known, for example, that the design point of a gas turbine optimised for simple cycle performance is not generally optimal for combined cycle gas turbine performance. The same phenomenon may be observed in combined fuel cell and gas turbine cycles, where both the fuel cell and the gas turbine are likely to differ from those which would be selected for peak simple cycle efficiency. The implications of this for practical fuel cell and gas turbine combined cycles and for development targets for solid oxide fuel cells are discussed. Finally, a brief comparison of the economics of simple cycle fuel cells, simple cycle gas turbines and fuel cell and gas turbine combined cycles is presented, illustrating the benefits which could result.
International workshop on immune tolerance induction: consensus recommendations<sup>1</sup> (2007)

Although immune tolerance induction (ITI) has been used for 30 years to eliminate inhibitors and restore normal factor pharmacokinetics in patients with hemophilia, there is a paucity of scientific evidence to guide therapeutic decision-making. In an effort to provide direction for physicians and hemophilia treatment center staff members, an international panel of hemophilia opinion leaders met to develop consensus recommendations for ITI in patients with severe and mild hemophilia A and hemophilia B. These recommendations draw on the available published literature and the collective clinical experience of the group and are rated based on the level of supporting evidence.
On connected degree sequences (2015)

This note gives necessary and sufficient conditions for a sequence of non-negative integers to be the degree sequence of a connected simple graph. This result is implicit in a paper of Hakimi. A new alternative characterisation of these necessary and sufficient conditions is also given.
Value of fluorodeoxyglucose positron emission tomography in characterizing clinically-significant thyroid carcinomas (2011)

Background: Despite the rising incidence of thyroid incidentalomas, their clinical significance remains unclear. The present study aimed to determine whether fluorodeoxyglucose positron emission tomography (FDG-PET) is associated with a significantly higher risk of clinically-significant thyroid carcinoma (CSC) in incidentalomas than other non-functional imaging modalities. Methods: Over a 2-year period, 89 patients were identified as having a thyroid incidentaloma. All patients had either surgery or fine needle aspiration cytology (FNAC) with a 12-month follow up to confirm the nature of the incidentaloma. Surgery was carried out for nodules with malignant or indeterminate FNAC result, or those with in a retrosternal location, with size > 4 cm or local symptoms. Results: A total of 21 (23.6%) patients had their incidentaloma detected by FDG-PET (PET group) and 68 (76.4%) by non-PET imaging modalities (non-PET group). Differentiated thyroid carcinoma was confirmed in 18 (20.2%) patients. The rate of malignancy was 61.9% in the PET group and 7.4% in the non-PET group (P = 0.001). After excluding the occult microcarcinomas, the risk of malignancy reduced to 14.6%, but the difference in malignancy rate became more marked between the PET and non-PET group (42.9% vs 2.9%, P = 0.001). The maximum standardized uptake value on FDG-PET was similar between benign and malignant lesions (P = 0.124). Conclusion: The overall risk of CSC in thyroid incidentalomas was 14.6%. Those detected by FDG-PET were significantly more likely to harbour CSC than those by non-functional modalities. Incidentalomas with focal FDG uptake should be thoroughly investigated with USG and FNAC.
Chromatography of Anthocyanins on Columns of Insoluble Polyvinylpyrrolidone (1971)

Journal Article Chromatography of Anthocyanins on Columns of Insoluble Polyvinylpyrrolidone Get access Cornelis G. Van Teeling, Cornelis G. Van Teeling Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter E. Cansfield, Peter E. Cansfield Search for other works by this author on: Oxford Academic PubMed Google Scholar Reg A. Gallop Reg A. Gallop Food Science Department, University of Manitoba, Fort Garry, Winnipeg 19, Manitoba, Canada. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Chromatographic Science, Volume 9, Issue 8, August 1971, Pages 505–509, https://doi.org/10.1093/chromsci/9.8.505 Published: 01 August 1971 Article history Received: 11 November 1970 Published: 01 August 1971
A novel optical encoding scheme for network node tracing in all-optical reconfigurable wavelength routing networks (2009)

An optical prime-number-encoded tag is employed as distinct network node identifier so as to realize network node tracing in reconfigurable wavelength routing networks, via prime number multiplication. Possible network looping problem can also be identified.
Optimized performance of erbium-doped fiber amplifiers in subcarrier multiplexed lightwave AM-VSB CATV systems (1991)

The authors study the effects of noise when erbium-doped fiber amplifiers are used as signal boosters for signal distribution in amplitude modulation, vestigial-sideband (AM-VSB) subcarrier multiplexed lightwave cable television (CATV) systems. A procedure for finding the amplifier length required to achieve a desired carrier-to-noise ratio at the receiver, while maximizing the allowed post-amplifier splitting ratios and transmission losses has been developed. A simple and easy-to-use approach that circumvents the computationally intensive optimization procedure and allows the design of systems whose performance is very close to optimal is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>