gebhart/patrepeval huggingface dataset:
Primary translation products, biosynthesis, and tissue specificity of the major surfactant protein in rat. (1986)

Rat lung tissue was labeled with [35S]methionine and the major surfactant-associated proteins immunoprecipitated using a specific antiserum. The protein pattern obtained was very similar to that seen in rat bronchoalveolar lavage. Rat lung mRNA was subsequently translated in an in vitro rabbit reticulocyte system, and surfactant-associated protein-related polypeptides were immunoprecipitated. A 26-kDa polypeptide was identified and characterized as follows. (a) Unlabeled surfactant proteins added to the immunoprecipitation mixture completely inhibited its immunoprecipitation. (b) Two-dimensional gel electrophoresis of the 26-kDa protein resolved it into 3 isoforms. (c) Inclusion of dog pancreatic microsomes in the translation mixture resulted in the formation of two distinct higher molecular weight groups of isoforms, suggesting that the 26-kDa protein is destined to become a glycoprotein. Immunoprecipitation of [35S]methionine-labeled rat lung tissue proteins after tunicamycin treatment resulted in 3 isoforms, identical to the ones seen in the primary translation products. In addition, expression of the surfactant proteins appears specific to the lung.
A microsystem for sensing and patterning oxidative microgradients during cell culture (2006)

We present the design, modeling, fabrication and testing of a microsystem for the electrolytic patterning and sensing of oxidative microgradients within 1 x 1 mm2 area during cell culture. The system employs an array of microfabricated electrodes (3-40 microm in width) embedded in gas-permeable microchannels to generate precise doses of dissolved oxygen (ranging from 10 fmol O2 mm(-2) s(-1) to 100 nmol O2 mm(-2) s(-1)) via electrolysis. The microgradients generated by different microelectrodes in the array can be superimposed to pattern multi-dimensional oxygen profiles not possible with other methods. We demonstrate the patterning, sensing and quantification of dissolved oxygen microgradients in the 0 to 40% dO2 range using this microsystem. Reactive oxygen species generation and dosing is also quantified. Lastly, we demonstrate how the microtechnology enables new types of experiments in three different cell culture models: localized hyperoxia-induced apoptosis in C2C12 myoblasts, dynamic aerotaxis assays of Bacillus subtilis, and studies of calcium release in an ischemia/re-oxygenation myoblast model.
Influence of Air SO2 Pollution on Antioxidant Systems of Alfalfa Inoculated with Rhizobium. (2015)

Air pollution is the most important environmental problem of last century that threatens the health of living organisms, especially plants. SO2 is one of the main air pollutants that can cause to imbalance in growth and physiological function of plant in high concentrations. Symbiosis of Rhizobium bacteria with alfalfa can cause increasing plant growth and plant resistance to abiotic stresses. In order to study the effects of rhizobia inoculation on alfalfa antioxidants activity and capacity under air SO2 pollution, 35 days plants (noninoculated and inoculated with native or standard Rhizobium meliloti) exposed to the different concentrations of SO2 (0 as a control, 0.5, 1, 1.5 and 2 ppm) for 6 consecutive days (2 hours per day). Results showed inoculation had no significant effect on antioxidants activity and capacity of alfalfa plant. Different concentrations of SO2 pollution had a significant effect on alfalfa antioxidant system. Increasing SO2 stress increased antioxidant activities (I%) and decreased antioxidant capacities (IC50) of alfalfa leaves significantly in comparison to the control plants (under 0 ppm) as well as increased Superoxide dismutase, catalase and Guaiacol peroxidase activity. Inoculation of alfalfa plant with Rhizobium meliloti reduced significantly the negative effects of high concentration of SO2 on antioxidants activity and capacity. In fact, the rate of this change of antioxidant system under SO2 pollution in inoculated plants was lower than in the noninoculated plants. Therefore inoculation with Rhizobium strains could alleviate the effect of SO2 pollution on antioxidant system.
Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients (2001)

To comparatively assess first-line treatment with fludarabine and 2 anthracycline-containing regimens, namely CAP (cyclophosphamide, doxorubicin plus prednisone) and ChOP (cyclophosphamide, vincristine, prednisone plus doxorubicin), in advanced stages of chronic lymphocytic leukemia (CLL), previously untreated patients with stage B or C CLL were randomly allocated to receive 6 monthly courses of either ChOP, CAP, or fludarabine (FAMP), stratified based on the Binet stages. End points were overall survival, treatment response, and tolerance. From June 1, 1990 to April 15, 1998, 938 patients (651 stage B and 287 stage C) were randomized in 73 centers. Compared to ChOP and FAMP, CAP induced lower overall remission rates (58.2%; ChOP, 71.5%; FAMP; 71.1%; P <.0001 for each), including lower clinical remission rates (CAP, 15.2%; ChOP, 29.6%; FAMP, 40.1%; P =.003). By contrast, median survival time did not differ significantly according to randomization (67, 70, and 69 months in the ChOP, CAP, and FAMP groups, respectively). Incidences of infections (< 5%) and autoimmune hemolytic anemia (< 2%) during the 6 courses were similar in the randomized groups, whereas fludarabine induced, compared to ChOP and CAP, more frequent protracted thrombocytopenia (P =.003) and less frequent nausea-vomiting (P =.003) and hair loss (P <.0001). For patients with stage B and C CLL first-line fludarabine and ChOP regimens both provided similar overall survival and close response rates, and better results than CAP. However, there was an increase in clinical remission rate and a trend toward a better tolerance of fludarabine over ChOP that may influence the choice between these regimens as front-line treatments in patients with CLL.
COVERT: Compositional Analysis of Android Inter-App Permission Leakage (2015)

Android is the most popular platform for mobile devices. It facilitates sharing of data and services among applications using a rich inter-app communication system. While access to resources can be controlled by the Android permission system, enforcing permissions is not sufficient to prevent security violations, as permissions may be mismanaged, intentionally or unintentionally. Android’s enforcement of the permissions is at the level of individual apps, allowing multiple malicious apps to collude and combine their permissions or to trick vulnerable apps to perform actions on their behalf that are beyond their individual privileges. In this paper, we present <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> COVERT</i> , a tool for compositional analysis of Android inter-app vulnerabilities. COVERT’s analysis is modular to enable incremental analysis of applications as they are installed, updated, and removed. It statically analyzes the reverse engineered source code of each individual app, and extracts relevant security specifications in a format suitable for formal verification. Given a collection of specifications extracted in this way, a formal analysis engine (e.g., model checker) is then used to verify whether it is safe for a combination of applications—holding certain permissions and potentially interacting with each other—to be installed together. Our experience with using COVERT to examine over 500 real-world apps corroborates its ability to find inter-app vulnerabilities in bundles of some of the most popular apps on the market.
Evidence for cross-pathway regulation of metabolic gene expression in plants. (1995)

In Arabidopsis thaliana, blocking histidine biosynthesis with a specific inhibitor of imidazoleglycerol-phosphate dehydratase caused increased expression of eight genes involved in the biosynthesis of aromatic amino acids, histidine, lysine, and purines. A decrease in expression of glutamine synthetase was also observed. Addition of histidine eliminated the gene-regulating effects of the inhibitor, demonstrating that the changes in gene expression resulted from histidine-pathway blockage. These results show that plants are capable of cross-pathway metabolic regulation.
A Notch Filter for the Spin Component of a Two-Axis Gyro (1989)

Strapdown navigation system performance is increasingly dependent upon the noise characteristics of the measurement sensors. In this paper, a method of annihilating the noise component at gyro spin frequency is proposed which uses a digital finite impulse response (FIR) filter implemented in series with the gyro incremental output. The innovation is to exploit the all-zero nature of FIR filters (infinite attenuation at discrete frequencies) to produce the notching effect. Such a solution based on a FIR filter requires less processing than the corresponding digital notch design based upon the analog prototype. This technique is applied to a two-axis gyro simulation, and results are presented which indicate a noticeable improvement in noise level.
THE INTERACTION OF 5,7-DIBROMOISATOIC ANHYDRIDE WITH ANILINE (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE INTERACTION OF 5,7-DIBROMOISATOIC ANHYDRIDE WITH ANILINEFRED E. SHEIBLEYCite this: J. Org. Chem. 1952, 17, 2, 221–225Publication Date (Print):February 1, 1952Publication History Published online1 May 2002Published inissue 1 February 1952https://pubs.acs.org/doi/10.1021/jo01136a007https://doi.org/10.1021/jo01136a007research-articleACS PublicationsRequest reuse permissionsArticle Views118Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy of Guava (Psidium Guajava) Extract Against Some Fish and Shrimp Pathogenic Agents (1997)

Guava (Psidium guajava) extract was tested for anti viral activity against the fish pathogenic viruses, infectious haematopoietic necrosis virus (IHNV), infectious pancreatic necrosis virus (IPNV), and Oncorhynchus masou virus (OMV) using plaque reduction in CHSE-214 cell lines. Anti viral tests against the shrimp pathogenic virus, yellow-head virus (YHV), was carried out using the injection method. The efficacy of guava extract was also determined using MIC of the extract against 24 strains of pathogenic bacteria including; Vibrio harveyi (9 strains), V. splendidus (7 strains), V. parahaemolyticus (2 strains) and 1 strain of each V. mimicus, V. vulnificus, V. fluvialis, V. chorelae, V. alginolyticus and Aeromonas hydrophila. A toxicity test of the extract was performed with CHSE-214 cell lines and post larvae 15 of black tiger shrimp (Penaeus monodon). The efficacy of guava extract for the prevention of viral disease and bacterial disease in aquatic animals was estimated using YHV infection in black tiger shrimp and A. hydrophila infection in catfish, respectively. The extract of guava demonstrated anti viral activity against IHNV, OMV and YHV but was not effective for IPNV. Furthermore, the MIC of the extract ranged from 625 - 5,000 μg/ml against all pathogenic bacterial strains tested. The 50% cytotoxicity of the extract to CHSE-214 was 1,923 μg/ml while the LD50 of the extract to black tiger shrimp post larvae was 2,968 ± 3.8 μg/ml. These results show that guava extract has low toxicity to salmon cell lines and black tiger shrimp. Moreover, the extract is effective for prevention of bacterial infection in catfish (Clarias macrocephalus) while not suitable for prevention of yellow-head virus infection in black tiger shrimp. From these results, guava can be recommended for treatment of bacterial disease in fish. The route of administration and effective dose should be determined before their efficacy can be tested in field trials.
Surface-based determination of the pelvic coordinate system (2009)

In total hip replacement (THR) one technical factor influencing the risk of dislocation is cup orientation. Computer-assisted surgery systems allow for cup navigation in anatomy-based reference frames. The pelvic coordinate system most used for cup navigation in THR is based on the mid-sagittal plane (MSP) and the anterior pelvic plane (APP). From a geometrical point of view, the MSP can be considered as a mirror plane, whereas the APP can be considered as a tangent plane comprising the anterior superior iliac spines (ASIS) and the pubic tubercles. In most systems relying on the pelvic coordinate system, the most anterior points of the ASIS and the pubic tubercles are selected manually. As manual selection of landmark points is a tedious, time-consuming and error-prone task, a surface-based approach for combined MSP and APP computation is presented in this paper: Homologous points defining the MSP and the landmark points defining the APP are selected automatically from surface patches. It is investigated how MSP computation can benefit from APP computation and vice versa, and clinical perspectives of combined MSP and APP computation are discussed. Experimental results on computed tomography data show that the surface-based approach can improve accuracy.
Light‐Regulated Stapled Peptides to Inhibit Protein–Protein Interactions Involved in Clathrin‐Mediated Endocytosis (2013)

Control of membrane traffic: Photoswitchable inhibitors of protein-protein interactions were applied to photoregulate clathrin-mediated endocytosis (CME) in living cells. Traffic light (TL) peptides acting as "stop" and "go" signals for membrane traffic can be used to dissect the role of CME in receptor internalization and in cell growth, division, and differentiation.
Scheduling time-constrained instructions on pipelined processors (2001)

In this work we investigate the problem of scheduling instructions on idealized microprocessors with multiple pipelines, in the presence of precedence constraints, release-times, deadlines, and latency constraints. A latency of l ij specifies that there must be at least l ij time-steps between the completion time of instruction i and the start time of instruction j . A latency of l ij =−1 can be used to specify that j may be scheduled concurrently with i but not earlier. We present a generic algorithm that runs in O ( n 2 log n α( n )+ ne ) time, given n instructions and e edges in the precedence DAG, where α( n ) is the functional inverse of the Ackermann function. Our algorithm can be used to construct feasible schedules for various classes of instances, including instances with the following configurations: (1) one pipeline, with individual release-times and deadlines and where the latencies between instructions are restricted to 0 and 1; (2) m pipelines, with individual release-times and deadlines, and monotone-interval order precedences; (3) two pipelines with latencies of −1 or 0, and release-times and deadlines; (4) one pipeline, latencies of 0 or 1 and individual processing times that are at least one; (5) m pipelines, intree precedences, constant latencies, and deadlines; (6) m pipelines, outtree precedences, constant latencies, and release-times. For instances with deadlines, optimal schedules that minimize the maximal tardiness can be constructed using binary search, in O (log n ) iterations of our algorithm. We obtain our results using backward scheduling, a very general relaxation method, which extends, unifies, and clarifies many previous results on instruction scheduling for pipelined and parallel machines.
ChemInform Abstract: Alkoxo and Amido Compounds of Group 13 (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A stimulated echo artifact from slice interference in magnetic resonance imaging (1987)

When multiple slices are imaged with a short time between slice acquisitions, a disturbing line artifact along the direction of frequency encoding is often seen across the center of the images. The artifact consists of alternating bright and dark pixel intensities. In this paper, we show that the artifact is due to slice interference, and is caused by stimulated echoes that are produced in the regions of overlap between slices. A theoretical analysis of the formation of these stimulated echoes leads to ways of reducing the artifact, which are verified experimentally. The artifact can be suppressed most conveniently by extending the duration of the read gradient beyond the sampling window.
Novel polysilicon comb actuators for xy-stages (1992)

Different types of polysilicon comb actuators have been designed, fabricated, and operated. The design was based on a finite-element stiffness modeling of the suspensions. In particular, a new straight beam structure showed an improved mechanical stability compared with the classical folded beam actuators. IC-compatible sacrificial layer technology was used for the fabrication of the polysilicon structures. Electrostatic actuation of the straight beam elements resulted in displacements as a function of the applied voltage; a maximum of 2.7 mu m was achieved for 200 V. To lower this rather high driving voltage, the authors propose a comb actuator where several combs are placed in parallel to form a sarcomere actuator. By assembling four actuators, a comb-driven xy-microstage has been realized. Mechanical operation of this microrobot allowed the positioning of the center stage at any point in a 30 by 30 mu m area. Electrostatically the table was moved up to 1 mu m in each of the four directions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Thermal Stability of the <i>Fusarium solani pisi</i> Cutinase as a Function of pH (2001)

We have investigated the thermal stability of the Fusarium solani pisi cutinase as a function of pH, in the range from pH 2-12. Its highest enzymatic activity coincides with the pH-range at which it displays its highest thermal stability. The unfolding of the enzyme as a function of pH was investigated by microcalorimetry. The ratio between the calorimetric enthalpy (DeltaH(cal)) and the van't Hoff enthalpy (DeltaH(v)) obtained, is far from unity, indicating that cutinase does not exhibit a simple two state unfolding behaviour. The role of pH on the electrostatic contribution to the thermal stability was assessed using TITRA. We propose a molecular interpretation for the pH-variation in enzymatic activity.
Convolutionally encoded phase-shift-key modulation for multimedia multicast transmission in mobile wireless networks (2002)

In a wireless communication network it is often necessary to transmit one or more messages to multiple destinations, Some of the intended recipients may be more capable than others in the sense that their communication links from the transmitter have less interference, fading, or attenuation. We have previously proposed modulation techniques that allow a transmitter to deliver a basic level of information to all of the intended receivers and additional information to the more capable receivers. In this paper, convolutional coding is applied to the multicast modulation system to provide greater efficiency. Performance results and tradeoffs are presented for convolutionally encoded coherent M-ary phase-shift-key multicast transmissions. For the code and modulation considered in this paper, we show that error-control coding should not be applied to the additional information for network-traffic that can tolerate a probability of bit error greater than 10/sup -4/, such as voice traffic. Error-control coding should be applied to the additional information for network traffic that requires a probability of bit error less than 10/sup -4/.
GStream: a graph streaming processing method for large-scale graphs on GPUs (2015)

Fast processing graph algorithms for large-scale graphs becomes increasingly important. Besides, there have been many attempts to process graph applications by exploiting the massive amount of parallelism of GPUs. However, most of the existing methods fail to process large-scale graphs that do not fit in GPU device memory. We propose a fast and scalable parallel processing method GStream that fully exploits the computational power of GPUs for processing large-scale graphs (e.g., billions vertices) very efficiently. It exploits the concept of nested-loop theta-join and multiple asynchronous GPU streams. Extensive experimental results show that GStream consistently and significantly outperforms the state-of-the art method.
Real power to the people (1991)

Trevor Clay speaks his mind on improvements to the Citizen’s Charter, support for the new Chief Nursing Officer, a dwindling AIDS agenda - and a new breed of nursing student
Bandwidth Adaptation for MPEG-4 Video Streaming over the Internet (2002)

Trypanosoma brucei and other African trypanosomes are vector-borne parasites that cause substantial human suffering across sub-Saharan Africa. The T. brucei life cycle is punctuated by numerous developmental stages, each occurring in a specific environmental niche and characterized by a unique morphology, metabolism, surface protein coat, and gene expression profile. The environmental cues and signaling pathways that drive transitions between these stages remain incompletely understood. Recent studies have started to fill this gap in knowledge. Likewise, several new studies have expanded our understanding of parasite movement through specific tissues and the parasite's ability to alter movement in response to external cues. Life cycle stage differentiation and motility are intimately integrated phenomena, as parasites must be at the right place (i.e., within a specific environmental milieu) at the right time (i.e., when they are appropriately staged and preadapted for perceiving and responding to signals) in order to complete their life cycle. In this review, we highlight some of the recent work that has transformed our understanding of signaling events that control parasite differentiation and motility. Increased knowledge of T. brucei environmental sensing and signal transduction advances our understanding of parasite biology and may direct prospective chemotherapeutic and transmission blockade strategies that are critical to eradication efforts.
Mosaic of near ground UAV videos under parallax effects (2012)

Abstract—This paper explores the exciting possibility of using Google Earth as a software laboratory for studying wide-area scene analysis using near-ground aerial imagery. To this end we present a new image mosaicing algorithm capable of generating large mosaics from imagery captured by a near-ground aerial vehicle. Our algorithm eschews camera calibration and can handle strong parallax effects visible in the captured imagery. The imagery is generated by simulating an aerial vehicle flying over the New York city within the Google Earth environment. We also evaluate the proposed approach on a real dataset captured by a physical aerial vehicle, demonstrating that the algorithm that was initially developing using synthetic imagery does indeed work on real data. I.