gebhart/patrepeval huggingface dataset:
Hyperhidrosis and Botulinum Toxin in Dermatology (2002)

In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgica
Intracoronary stenting: An overview for the clinician (1999)

Intracoronary stenting reduces restenosis rates and effectively treats abrupt vessel closure, two frequent complications following percutaneous coronary angioplasty (PTCA). But it has drawbacks, such as in-stent restenosis, high cost, and lack of long-term follow-up data. This paper discusses current indications and the future role of stenting.
von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation (2006)

The pathogenicity of Plasmodium falciparum is thought to relate to the unique ability of infected erythrocytes to adhere to and subsequently activate the vascular endothelium. To study the state of endothelial activation during falciparum malaria, we measured plasma levels of both von Willebrand factor (VWF) and its propeptide, indices of chronic and acute endothelial cell perturbation, respectively. Results were correlated with clinical and biochemical markers of disease severity, including plasma lactate. Our data show that acute endothelial cell activation is a hallmark of malaria in children, indicated by a significant rise in VWF and VWF propeptide. The highest VWF and propeptide levels were seen in cerebral and non-cerebral severe malaria, and associations found between VWF propeptide level and lactate (P < 0.001). Mean VWF propeptide levels (nmol/l) were in cerebral malaria 33.4, non-cerebral severe malaria 26.3, mild malaria 22.1, non-malaria febrile illness 10.2, and controls 10.1. Differences between patient and control groups were highly significant (P < 0.005). Follow-up of 26 cerebral malaria cases showed that levels of VWF propeptide, but not VWF fell by 24 h, following the clinical course of disease and recovery. These novel findings potentially implicate acute, regulated exocytosis of endothelial cell Weibel-Palade bodies in the pathogenesis of Plasmodium falciparum malaria.
Tone mapping for high dynamic range displays (2007)

We address the problem of re-rendering images to high dynamic range (HDR) displays, which were originally tone-mapped to standard displays. As these new HDR displays have a much larger dynamic range than standard displays, an image rendered to standard monitors is likely to look too bright when displayed on a HDR monitor. Moreover, because of the operations performed during capture and rendering to standard displays, the specular highlights are likely to have been clipped or compressed, which causes a loss of realism. We propose a tone scale function to re-render images first tone-mapped to standard displays, that focuses on the representation of specular highlights. The shape of the tone scale function depends on the segmentation of the input image into its diffuse and specular components. In this article, we describe a method to perform this segmentation automatically. Our method detects specular highlights by using two low-pass filters of different sizes combined with morphological operators. The results show that our method successfully detects small and middle sized specular highlights. The locations of specular highlights define a mask used for the construction of the tone scale function. We then propose two ways of applying the tone scale, the global version that applies the same curve to each pixel in the image and the local version that uses spatial information given by the mask to apply the tone scale differently to diffuse and to specular pixels.
Controlled Growth of Large-Area, Uniform, Vertically Aligned Arrays of α-Fe<sub>2</sub>O<sub>3</sub> Nanobelts and Nanowires (2004)

Vertically aligned iron oxide nanobelt and nanowire arrays have been synthesized on a large-area surface by direct thermal oxidation of iron substrates under the flow of O(2). The effects of reactive gas pressure, composition, and temperature have been systematically studied. It was found that nanobelts (width, tens of nanometers; thickness, a few nanometers) are produced in the low-temperature region (approximately 700 degrees C) whereas cylindrical nanowires tens of nanometers thick are formed at relatively higher temperatures (approximately 800 degrees C). Both nanobelts and nanowires are mostly bicrystallites with a length of tens of micrometers which grow uniquely along the [110] direction. The growth habits of the nanobelts and nanowires in the two temperature regions indicate the role of growth rate anisotropy and surface energy in dictating the ultimate nanomorphologies.
Sampling And Reconstruction Of Non-Bandlimited Signals Using Slepian Functions (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008
A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis (2007)

Lipid lowering with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or 'statins' has dramatically reduced morbidity and mortality in patients with established cardiovascular disease. Recently, there have been multiple studies investigating the role of high-dose statin therapy with more aggressive lipid lowering in this setting. Concomitantly, there is increasing evidence implicating a role of inflammation in the pathogenesis of atherosclerosis. These high-dose statin trials and other studies have also provided a wealth of data suggesting that statins have anti-inflammatory and anti-oxidant properties that go beyond their lipid-lowering effects. In this review, we will provide a brief overview of recent, large-scale, randomized, placebo and active controlled trials of high-dose statin therapy in the setting of stable and unstable coronary artery disease and percutaneous coronary intervention. Further, we will discuss the evidence for effects of high-dose statin therapy on inflammation and C-reactive protein.
Stimulation of mononuclear cell binding to human endothelial cell monolayers by thrombin. (1988)

The common occurrence of fibrin deposits in chronic inflammatory lesions suggests a possible role for thrombin in the mobilization of mononuclear cell infiltrates. For this reason, the effect of thrombin on the binding of mononuclear cells to endothelial cells (EC) was investigated. Incubation of confluent monolayers of human umbilical vein endothelial cells with thrombin markedly enhanced EC adhesiveness for both T lymphocytes and U937 cells (a monocyte-like cell line) in a time- and dose-dependent fashion. This effect was EC specific: 1) treatment of the T cells or the U937 cells with thrombin did not stimulate their adherence to EC, and 2) treatment of human foreskin fibroblasts with thrombin did not stimulate their inherently low adhesiveness for T cells. Fixation of EC monolayers with paraformaldehyde after pre-incubation with thrombin did not affect the increased adhesiveness for T cells. mAb against the LFA-1 antigen (mAb 60.3 (anti-CD18) or mAb TS1/22 (anti-CD11a), which inhibit the binding of T cells to unstimulated EC, failed to block the increased adhesion induced by thrombin, indicating that the increased binding induced by thrombin is similar to that induced by IL-1 and TNF, which showed similar resistance. These results suggest that thrombin may have a role in the extravascular emigration of mononuclear cells from post-capillary venules by virtue of its ability to stimulate the adhesiveness of EC for both lymphocytes and monocytes.
Effect of Large Perturbation Amplitudes on the Impedance Response of an Electrochemical System (2008)

Numerical simulations of electrochemical systems were used to explore the inﬂuence of large-amplitude potential perturbations on the measured impedance response. The amplitude of the input potential perturbation used for impedance measurements, normally ﬁxed at a value of 10 mV for all systems, should instead be adjusted for each experimental system. Guidelines are developed for selection of appropriate perturbation amplitudes. A characteristic transition frequency is deﬁned that can be used to tailor a frequency-dependent input signal to optimize signal-to-noise levels while maintaining a linear response.
Exsolution Enhanced Oil Recovery with Concurrent CO2 Sequestration (2013)

A novel EOR method using carbonated water injection followed by depressurization is introduced. Results from micromodel experiments are presented to demonstrate the fundamental principles of this oil recovery method. A depressurization process (1 MPa/hr) was applied to a micromodel following carbonated water injection (Ca ≈ 10-5). The exsolved CO2 in water-filled pores blocked water flow in swiped portions and displaced water into oil-filled pores. Trapped oil after the carbonated water injection was mobilized by sequentially invading water. This method's self-distributed mobility control and local clogging was tested in a sandstone sample under reservoir conditions. A 10% incremental oil recovery was achieved by lowering the pressure 2 MPa below the CO2 liberation pressure. Additionally, exsolved CO2 resides in the pores of a reservoir as an immobile phase with a high residual saturation after oil production, exhibiting a potential synergy opportunity between CO2 EOR and CO2 sequestration.
Holographic optical element for an optical disk head with spot-size detection servo optics (1990)

A CGH construction of a holographic optical element (HOE) for an optical disk head with spot-size detection by means of superimposing two Fresnel zone plates is studied. Optimum parameter values for the ratio of segment to grating pitch (duty) and grating height are clarified from the viewpoint of total light power efficiency in the round trip optical system. The influences of higher-order diffracted beams near the first-order diffracted beams used to get signals on signal detection are shown to be small. The HOEs with almost optimum parameter values are fabricated and the desired diffracted spots, the expected total light power efficiency, and the small influence of higher-order diffracted beams are observed.
Learning Dense Representations for Entity Retrieval (2019)

Daniel Gillick, Sayali Kulkarni, Larry Lansing, Alessandro Presta, Jason Baldridge, Eugene Ie, Diego Garcia-Olano. Proceedings of the 23rd Conference on Computational Natural Language Learning (CoNLL). 2019.
Fluorescence in situ hybridization: A brief review (1996)

Fluorescence in situ hybridization (FISH) is used for many purposes, including analysis of chromosomal damage, gene mapping, clinical diagnostics, molecular toxicology and cross-species chromosome homology. FISH allows an investigator to identify the presence and location of a region of cellular DNA or RNA within morphologically preserved chromosome preparations, fixed cells or tissue sections. This report describes in situ hybridization, and discusses the past, present and future applications of this method for genetic analysis and molecular toxicology.
Potential Antitumor Agents, VII. 5‐Substituted 6‐Phenylimidazo[2,1‐<i>b</i>]thiazoles (1982)

Abstract The Vilsmeier reaction for the synthesis of the 5‐formylimidazo[2,1‐ b ]thiazoles 7–12 bearing a p ‐substituted phenyl ring in position 6 is reported. These compounds were used for the synthesis of the thiosemicarbazones 7a‐12a , tosylhydrazones 7b‐12b and 5‐hydroxymethyl derivatives 13–18 which, in turn, were used as starting materials for preparing the methylcarbamic 13a‐18a , ethylcarbamic 13b‐18b and acetic esters 13c‐18c . Preliminary results in the P‐388 leukemia test are reported.
Direct anterior total hip arthroplasty: complications and early outcome in a series of 300 cases. (2013)

The direct anterior approach for total hip arthroplasty has gained popularity throughout the last decade. Early reports showed successful results with rapid functional recovery and low dislocation rates. However there is some concern about the high number of complications induced by the technique. The aim of this study was to examine the early radiological outcome and perioperative complications in a consecutive series of 300 total hip arthroplasties performed through a minimal invasive anterior approach with the aid of a positioning table. We observed 9(3%) intra-operative complications : two femoral perforations, 4 calcar fractures and 3 greater trochanter fractures. There were 42 (14%) postoperative complications and 20 (6.7%) patients required a surgical re-intervention. Our major finding was early peri-prosthetic femoral fracture in 5 patients, not noticed during surgery. The dislocation ratio (2 cases, 0.66%) was low. The complication ratio decreased throughout our series, but statistical significance could not be shown (p = 0.26). Surgeons should be aware of the high risk of occult intra-operative fractures when starting with this technique.
Use of bortezomib in the management of chronic graft-versus-host disease among multiple myeloma patients relapsing after allogeneic transplantation (2007)

We report on the use of bortezomib for the management of chronic graft versus host disease (cGVHD) among 8 multiple myeloma (MM) patients who relapsed after reduced-intensity conditioning (RIC) allogeneic transplantation. Five patients (62%) responded to bortezomib demonstrating anti-myeloma effect. Four patients had active cGVHD, including 3 patients with severe punctate keratopathy, at the time of bortezomib administration. All showed an improvement in their condition. This is the first report showing that bortezomib may be useful in the management of cGVHD and related ocular involvement.
An Effective Economic Management of Resources in Cloud Computing (2011)

In Cloud computing, the availability and performance of services are two important aspects to be lifted, because users require a certain level of quality service in terms of timeliness of their duties in a lower cost. Several studies have overcome this problem by the proposed algorithms borrowed from economic models of real world economy to ensure that quality of service, our job is to extend and enrich the simulator CloudSim by auction algorithms inherited from GridSim simulator, but its algorithms do not support the virtualization which is an important part of Cloud Computing, why we introduced several parameters and functions adapted to the environment of cloud computing as well as users to meet their requirements.
Ex Vivo and In Vivo Neuroprotection Induced by Argon When Given after an Excitotoxic or Ischemic Insult (2012)

In vitro studies have well established the neuroprotective action of the noble gas argon. However, only limited data from in vivo models are available, and particularly whether postexcitotoxic or postischemic argon can provide neuroprotection in vivo still remains to be demonstrated. Here, we investigated the possible neuroprotective effect of postexcitotoxic-postischemic argon both ex vivo in acute brain slices subjected to ischemia in the form of oxygen and glucose deprivation (OGD), and in vivo in rats subjected to an intrastriatal injection of N-methyl-D-aspartate (NMDA) or to the occlusion of middle-cerebral artery (MCAO). We show that postexcitotoxic-postischemic argon reduces OGD-induced cell injury in brain slices, and further reduces NMDA-induced brain damage and MCAO-induced cortical brain damage in rats. Contrasting with its beneficial effect at the cortical level, we show that postischemic argon increases MCAO-induced subcortical brain damage and provides no improvement of neurologic outcome as compared to control animals. These results extend previous data on the neuroprotective action of argon. Particularly, taken together with previous in vivo data that have shown that intraischemic argon has neuroprotective action at both the cortical and subcortical level, our findings on postischemic argon suggest that this noble gas could be administered during but not after ischemia, i.e. before but not after reperfusion has occurred, in order to provide cortical neuroprotection and to avoid increasing subcortical brain damage. Also, the effects of argon are discussed as regards to the oxygen-like chemical, pharmacological, and physical properties of argon.
Transplantation of Heterospheroids of Islet Cells and Mesenchymal Stem Cells for Effective Angiogenesis and Antiapoptosis (2014)

Although islet transplantation has been suggested as an alternative therapy for type 1 diabetes, there are efficiency concerns that are attributed to poor engraftment of transplanted islets. Hypoxic condition and delayed vasculogenesis induce necrosis and apoptosis of the transplanted islets. To overcome these limitations in islet transplantation, heterospheroids (HSs), which consist of rat islet cells (ICs) and human bone marrow-derived mesenchymal stem cells (hMSCs), were transplanted to the kidney and liver. The HSs cultured under the hypoxic condition system exhibited a significant increase in antiapoptotic gene expression in ICs. hMSCs in the HSs secreted angiogenic and antiapoptotic proteins. With the HS system, ICs and hMSCs were successfully located in the same area of the liver after transplantation of HSs through the portal vein, whereas the transplantation of islets and the dissociated hMSCs did not result in localization of transplanted ICs and hMSCs in the same area. HS transplantation resulted in an increase in angiogenesis at the transplantation area and a decrease in the apoptosis of transplanted ICs after transplantation into the kidney subcapsule compared with transplantation of islet cell clusters (ICCs). Insulin production levels of ICs were higher in the HS transplantation group compared with the ICC transplantation group. The HS system may be a more efficient transplantation method than the conventional methods for the treatment of type 1 diabetes.
High frame rate imaging system for limited diffraction array beam imaging with square-wave aperture weightings high frame rate imaging system for limited diffraction array beam imaging with square-wave aperture weightings (2006)

A general-purpose high frame rate (HFR) medical imaging system has been developed. This system has 128 independent linear transmitters, each of which is capable of producing an arbitrary broadband (about 0.05-10 MHz) waveform of up to +/- 144 V peak voltage on a 75-ohm resistive load using a 12-bit/40-MHz digital-to-analog converter. The system also has 128 independent, broadband (about 0.25-10 MHz), and time-variable-gain receiver channels, each of which has a 12-bit/40-MHz analog-to-digital converter and up to 512 MB of memory. The system is controlled by a personal computer (PC), and radio frequency echo data of each channel are transferred to the same PC via a standard USB 2.0 port for image reconstructions. Using the HFR imaging system, we have developed a new limited-diffraction array beam imaging method with square-wave aperture voltage weightings. With this method, in principle, only one or two transmitters are required to excite a fully populated two-dimensional (2-D) array transducer to achieve an equivalent dynamic focusing in both transmission and reception to reconstruct a high-quality three-dimensional image without the need of the time delays of traditional beam focusing and steering, potentially simplifying the transmitter subsystem of an imager. To validate the method, for simplicity, 2-D imaging experiments were performed using the system. In the in vitro experiment, a custom-made, 128-element, 0.32-mm pitch, 3.5-MHz center frequency linear array transducer with about 50% fractional bandwidth was used to reconstruct images of an ATS 539 tissue-mimicking phantom at an axial distance of 130 mm with a field of view of more than 90 degrees. In the in vivo experiment of a human heart, images with a field of view of more than 90 degrees at 120-mm axial distance were obtained with a 128-element, 2.5-MHz center frequency, 0.15-mm pitch Acuson V2 phased array. To ensure that the system was operated under the limits set by the U.S. Food and Drug Administration, the mechanical index, thermal index, and acoustic output were measured. Results show that higher-quality images can be reconstructed with the square-wave aperture weighting method due to an increased penetration depth as compared to the exact weighting method developed previously, and a frame rate of 486 per second was achieved at a pulse repetition frequency of about 5348 Hz for the human heart.
Performance of an ADPCM/TASI system for PCM speech compression (1981)

This paper contains a summary of performance measurements for a digital speech interpolation (DSI) system called adaptive differential PCM with time assignment speech interpolation (ADPCM/ TASI). This system is used to compress the output of two or more T1 PCM terminals into a bit rate normally requited by one such terminal. The performance measurements presented are as follows. 1) Signal-to-noise power ratios (SNR) for a 1004 Hz tone signal measured by a transmission impairment measuring test set (TIMS). 2) Idle channel noise performance measured by a TIMS. 3) SNR for speech measured by actual computation. These measurements were made for a variety of traffic loading conditions, and a number of different input power levels. The ADPCM/TASI system was constructed by using an AMD 2900 bit slice microprocessor architecture, but was designed to operate on only one speech channel. The presence of other active channels was simulated programatically. The performance of the system when voice band data signals occupy some of the T1 channels is discussed and is reflected in the measurements. An audio tape was made to demonstrate the subjective performance of the system with and without errors in the transmission medium. The objective performance of the system is compared to the D3 channel bank specifications.
Identifying an OpenID anti‐phishing scheme for cyberspace (2014)

Abstract OpenID is widely being used for user centric identity management in many Web applications. OpenID provides Web users with the ability to manage their identities through third party identity providers while remaining independent of the subject that actually uses the identities to authenticate individuals. Starting from the early stages of its inception, OpenID has received a large amount of acceptance and use in the current Web community because of its flexibility and ease of use. However, in addition to its benefits and flexibilities, OpenID faces its own share of vulnerabilities and threats, which have made its future and large‐scale use in cyberspace questionable. OpenID Phishing is one such attack that has received much attention and that requires a comprehensive solution. This paper aims at identifying and discussing a solution to OpenID Phishing by proposing a user authentication scheme that allows OpenID providers to identify a user using publicly known entities. The research will help in next‐generation cyber security innovations by reducing the authentication dependency on user credentials, that is, login name/password. The authentication scheme is also validated through detailed descriptions of use cases and prototype implementation. Copyright © 2014 John Wiley & Sons, Ltd.