gebhart/patrepeval huggingface dataset:
5-Hydroxytryptamine 5-HT2A receptor and 5-hydroxytryptamine transporter polymorphisms in acute myocardial infarction (2003)

This study was designed to analyse possible associations between DNA polymorphisms in the 5-hydroxytryptamine (5-HT; serotonin) 5-HT2A receptor and the 5-HT transporter (5-HTT) genes, and myocardial infarction (MI). 5-HT has been shown to be involved in cardiovascular pathophysiology. In addition to platelet aggregation and vascular contraction, 5-HT induces hyperplasia of artery smooth muscle cells. Recently, a 5-HT transporter gene polymorphism has been associated with MI. To determine the influence of genetic variation at the 5-HT2A receptor (T102C polymorphism) and the 5-HTT (insertion/deletion polymorphism) on the risk of developing early MI, we genotyped 210 MI patients of <55 years old and 238 healthy control subjects for DNA polymorphisms in these genes. In addition, we genotyped 95 patients with late-onset MI (>60 years old) to analyse the effects of these polymorphisms on the age at which the first MI episode occurred. The 5-HT2A receptor polymorphism was not associated with MI in our population. In addition, since the 5-HT2A receptor gene and genotype frequencies did not differ between patients with early and late onset of MI, this polymorphism does not appear to have an effect on age at the first MI episode. Gene and genotype frequencies for the 5-HTT promoter did not differ between patients <55 years old and healthy controls (independent of smoking status). However, homozygotes for the deletion (the ss genotype, where s denotes the short allele) were present at a significantly higher frequency in patients >60 years old compared with patients <55 years old (P = 0.009; P = 0.004 when only smokers were compared). According to our data, the ss genotype would seem to have a protective role against MI, delaying the age of onset of the first episode, especially among smokers. This could be a consequence of the lower 5-HTT levels linked to the s allele, so that individuals homozygous for the ss genotype may have lower 5-HT re-uptake by platelets.
Dynamic programming speech recognition using a context-free grammar (2005)

This paper deels with the use of context-free grammars in automatic speech recognition. A dynamic programming algorithm for recognizing and parsing spoken word strings of a context-free grammar is presented. The algorithm can be viewed as a probabilistic extension of the CYK algorithm along with the incorporation of the nonlineer time alignment. Details of the implementation and experimental tests are described.
A Trickle Irrigation System for Recycling Residential Wastewater on Fruit Trees (1986)

Abstract Certainly trickle (or drip) irrigation is not new to horticulture. In the early 1970s Chapin (1, 2, 3, 4), Gustafson (7, 8), and Hall (9) pioneered its use in horticultural crops in the United States. Kenworthy (10, 11, 12, 13) had introduced the concept of trickle irrigation to fruit growers in western Michigan by 1972. It appeared to be a “natural”; many growers already had deep wells (for hydrocooling cherries) available as excellent water sources. Since then the use of trickle irrigation has spread rapidly throughout the horticultural industry on a worldwide scale. Most draw on deep-well water or on canal, river, or lake water, which may require treatment, filtration or both to render it usable. However, the use of a trickle system for waste disposal was a new application of an existing technology.
MR imaging of susceptibility-induced magnetic field inhomogeneities. (1988)

A 90 degrees-tau 1-90 degrees-tau 2-image acquisition pulse sequence allows spatial mapping of resonant frequency. This sort of sequence has previously been used for magnet shimming, and its use in chemical-shift imaging has been proposed. The authors used this sequence in magnetic resonance imaging of a phantom to demonstrate the magnetic field gradients arising from susceptibility differences within the phantom and allow those gradients to be measured. Gradients may arise near interfaces between substances that cannot support the same magnetic flux density. The pulse sequence was found to work well in lower-field-strength instruments.
Polyphase apparent power and power factor under distorted waveform conditions (1991)

It is pointed out that the term apparent power does not have a unique meaning when used to describe polyphase, nonsinusoidal systems; in a general case it is an artificial concept with no physical interpretation. It is shown that this ambiguity can have implications for power factor calculations, reactive current compensation, and revenue metering. The time-domain based method of defining and measuring the apparent power is discussed. The necessity of a critical revision of terms relating to apparent power in the IEEE Standard Dictionary is pointed out.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Avian Paramyxoviruses from Migrating and Resident Ducks in Coastal Louisiana (1991)

Cloacal and tracheal swabs were collected from 1,409 hunter-killed ducks in Cameron Parish, Louisiana, during the 1986 and 1987 waterfowl seasons. Thirty avian paramyxoviruses (PMV's) were isolated from 605 blue-winged teal (Anas discors), 75 mottled ducks (A. fulvigula), 375 gadwalls (A. strepera), 334 green-winged teal (A. crecca), and 20 mallards (A. platyrhynchos). Prevalence of PMV decreased (P = 0.042) from September (4%) through November (2%) to December and January (1%). Juveniles had a higher prevalence of PMV (P less than 0.0001) than adults. An isolate from resident mottled ducks documents transmission of PMV's on the coastal wintering areas of Louisiana. The four serotypes isolated, PMV-1, PMV-4, PMV-6, and PMV-8, were typical of PMV's commonly associated with free-living waterfowl.
Adsorption of Metal Ions on a New Chelating Ion-Exchange Resin Chemically Derived from Chitosan (1991)

Abstract A new chelating ion-exchange resin, pyrididene-chitosan, was synthesized through the reaction of pyridine-2-aldehyde with the free amino groups of chitosan. The pH dependencies and adsorption isotherms in the adsorption of various metal ions on the resin were investigated from 1 mol/1 of aqueous ammonium nitrate solution.
XENOTRANSPLANTATTON OF PORCINE AND BOVINE ISLETS WITHOUT IMMUNOSUPPRESSION USING UNCOATED ALGINATE MICROSPHERES (1995)

Uncoated spherical hydrogel microspheres (calcium alginate, nominal M(r) exclusion of > 600 kD) 800-900 microns in diameter were employed to prevent immune rejection of discordant islet xenografts isolated from pigs and cows. The islets were immobilized in the microspheres and injected into the peritoneum of 14 nonimmunosuppressed streptozotocin (STZ)-induced diabetic C57BL/6J mice. Four recipients received islet grafts from bovine calves, and 10 received islet grafts from pigs. In the control group of 15 diabetic mice implanted with nonencapsulated islets, 6 received i.p. porcine islets and 5 received i.p. bovine islets, whereas remaining 4 received porcine islets under the kidney capsule. Plasma glucose concentrations in recipients of the alginate-encapsulated islets promptly dropped from a preimplantation value of 498 +/- 47 (mean +/- SEM) to 142 +/- 6 (bovine) and 178 +/- 7 mg/dl (porcine) during the first wk. All the animals sustained these levels for at least 1 mo. Two mice implanted with bovine islets subsequently reverted to diabetes (plasma glucose > 250 mg/dl) at 43 days postimplantation. The remaining grafts maintained function for > 10 wk. In contrast, nonencapsulated islets failed to function, or sustained euglycemia for < 4 days. Mice receiving encapsulated islets showed a 23-38% gain in body weight during the first mo after implantation, compared with < 1% (P < 0.002) and 32% (P = 0.84) for the untreated diabetic (n = 6) and normal control (n = 6) groups. Immunohistochemical staining of long-term grafts (> 10 wk) revealed viable islets, with well-granulated alpha, beta, and delta cells; the external surfaces of the microreactors were free of fibrotic overgrowth and exhibited only occasional host cell adherence. Uptake studies with IgG and thyroglobulin (M(r) of 669 kD) suggest that the microreactors were permeable to molecules with a molecular weight of up to > 600 kD (including the various proteins of the complement system, M(r) of 24-570 kD). Spheres implanted in the peritoneum after only 1 wk stained positive for both IgG and for the C3 component of complement. These findings suggest that prolonged survival of discordant xenografts of porcine and bovine islets in the STZ diabetic mouse model can be achieved with uncoated alginate microspheres that are permeable to IgG and complement. The question of whether similar results can be achieved with uncoated alginate microspheres in higher animals remains to be fully determined.
Electrochemical Definitions of O<sub>2</sub>Sensitivity and Oxidative Inactivation in Hydrogenases (2005)

A new strategy is described for comparing, quantitatively, the ability of hydrogenases to tolerate exposure to O2 and anoxic oxidizing conditions. Using protein film voltammetry, the inherent sensitivities to these challenges (thermodynamic potentials and rates of reactions) have been measured for enzymes from a range of mesophilic microorganisms. In the absence of O2, all the hydrogenases undergo reversible inactivation at various potentials above that of the H+/H2 redox couple, and H2 oxidation activities are thus limited to characteristic "potential windows". Reactions with O2 vary greatly; the [FeFe]-hydrogenase from Desulfovibrio desulfuricans ATCC 7757, an anaerobe, is irreversibly damaged by O2, surviving only if exposed to O2 in the anaerobically oxidized state (which therefore affords protection). In contrast, the membrane-bound [NiFe]-hydrogenase from the aerobe, Ralstonia eutropha, reacts reversibly with O2 even during turnover and continues to catalyze H2 oxidation in the presence of O2.
Overcoming DRAM scaling limitations by employing straight recessed channel array transistors with &gt;100&lt; uni-axial and [100] uni-plane channels (2006)

Recessed channel array transistors (RCAT) for DRAM are implemented with <100> uni-axial and {100} uni-plane channels for the first time. It is found that this structure improves the cell transistor drivability by 25% with the improvement being more effective in straight shape active RCAT than the diagonal shape active RCAT due to the larger dimension of the horizontal <100> axial channel in the {100} plane. Enhanced RCAT drivability improves tRDL (allowed time interval between data-in and word-line precharge) and retention time, which allows for lowering the gate voltage over-drive (VPP) in DRAM operation. This possibility provides a breakthrough in reliability limitations and leads to better performance in nano-scaled DRAM
An Efficient Vectorized Hash Table for Batch Computations (2016)

HighwayHash is a new pseudo-random function based on SIMD multiply and permute instructions for thorough and fast hashing. It is 5.2 times as fast as SipHash for 1 KiB inputs. An open-source implementation is available under a permissive license. We discuss design choices and provide statistical analysis, speed measurements and preliminary cryptanalysis. Assuming it withstands further analysis, strengthened variants may also substantially accelerate file checksums and stream ciphers.
ER model clustering as an aid for user communication and documentation in database design (1989)

Entity-relationship clustering promotes the simplicity that is vital for fast end-user comprehension, as well as the complexity at a more detailed level to satisfy the database designer's need for extended semantic expression in the conceptual model.
A new 2-D adaptive filter using affine projection algorithm (1998)

This paper proposes a realization of two-dimensional (2-D) adaptive finite impulse response (FIR) filters using the affine projection method. The convergence property of the proposed algorithm is superior to that of the 2-D least mean square (LMS) and normalized LMS (NLMS) algorithms. This algorithm has properties that lie between those of NLMS and recursive least squares (RLS) algorithms. The generalization of the proposed algorithm is also discussed. To illustrate the utility of the proposed technique, this filter is applied to the 2-D system identification.
Enzymic oxidation of o-aminophenols (1967)

K. Bailey and B. R. Brown, Chem. Commun. (London), 1967, 408b DOI: 10.1039/C1967000408B
Changes in the enzymatic hydrolysis rate of Avicel cellulose with conversion (2006)

The slow down in enzymatic hydrolysis of cellulose with conversion has often been attributed to declining reactivity of the substrate as the more easily reacted material is thought to be consumed preferentially. To better understand the cause of this phenomenon, the enzymatic reaction of the nearly pure cellulose in Avicel was interrupted over the course of nearly complete hydrolysis. Then, the solids were treated with proteinase to degrade the cellulase enzymes remaining on the solid surface, followed by proteinase inhibitors to inactive the proteinase and successive washing with water, 1.0 M NaCl solution, and water. Next, fresh cellulase and buffer were added to the solids to restart hydrolysis. The rate of cellulose hydrolysis, expressed as a percent of substrate remaining at that time, was approximately constant over a wide range of conversions for restart experiments but declined continually with conversion for uninterrupted hydrolysis. Furthermore, the cellulose hydrolysis rate per adsorbed enzyme was approximately constant for the restart procedure but declined with conversion when enzymes were left to react. Thus, the drop off in reaction rate for uninterrupted cellulose digestion by enzymes could not be attributed to changes in substrate reactivity, suggesting that other effects such as enzymes getting "stuck" or otherwise slowing down may be responsible.
Formation and Growth of Humins via Aldol Addition and Condensation during Acid-Catalyzed Conversion of 5-Hydroxymethylfurfural (2011)

The acid-catalyzed conversion of 5-hydroxymethylfurfural (HMF) produces levulinic and formic acids in equal amounts. Dark-colored solids, known as humins, are also formed in a parallel reaction. Aldol addition and condensation are proposed as important reactions in the acid-catalyzed growth of humins, adding HMF to 2,5-dioxo-6-hydroxy-hexanal. Consistent with this proposal, infrared (IR) spectra of humins formed from HMF indicate that the furan ring and hydroxymethyl group of HMF are present in the humins, but the carbonyl group is not. Similarly, if a mixture of HMF and benzaldehyde are processed, IR spectra of the humins indicate the additional presence of the aromatic ring from benzaldehyde but not its carbonyl group. The incorporation of the aromatic ring from benzaldehyde in the humins demonstrates the possibility of functionalizing humins to increase their value.
Sulfate supplementation of alpine goats: effects on milk yield and composition, metabolites, nutrient digestibilities, and acid-base balance2 (1992)

Effects of sulfate supplementation on milk yield and composition, ruminal and blood metabolites, acid-base status, and nutrient digestibilities were determined using 30 multiparous, lactating Alpine does. Goats were fed isonitrogenous diets containing .16 (basal), .26, or .36% S (DM basis) during a 13-wk lactation trial that coincided with wk 3 to 15 of lactation. During wk 16 to 17, four does from each treatment were placed in a metabolism crate to measure nutrient digestibility and balance. Feed intake, yield of 4% fat-corrected milk, and milk S content were not affected by added S, but the goats fed the .26% S diet had a trend of higher persistency of lactation (P < .20). During wk 10 and 15 of lactation, milk solids-not-fat percentage was higher (P < .10) for does fed the .26% S diet. Sulfur supplementation resulted in quadratic decreases in ruminal ammonia N (P < .05) in wk 15 and in plasma urea N in wk 10 and 15 (P < .05) but in linear increases (P < .05) in ruminal protein S concentrations throughout the experiment. Added S had little effect on blood acid-base status. Apparent digestibilities of DM, OM, ash, ADF, and GE were increased linearly (P < .10) by added S. The milk N:S ratio remained constant. Increasing S from .16 to .26% of diet DM was beneficial to lactating Alpine goats during early lactation.
The Double-Mirror Gonioscopic Lens for Surgery of the Anterior Chamber Angle (1997)

Intraoperative examination of the anterior chamber angle is necessary during several glaucoma procedures, including goniosynechialysis and goniotomy. Many of the available lenses for this purpose are difficult to use because they require oblique illumination and their size interferes with surgical manipulations at the limbus. We have developed a double-mirror gonioscopic lens that uses direct illumination; provides an upright image of angle structures; and has a small diameter, allowing simultaneous access to the entire limbal region. We compared our lens with the Posner goniomirror (Ocular Instruments, Bellvue, Wash) and found that it provides an equal view of angle structures. The double-mirror gonioscopic lens facilitates the intraoperative visualization of the anterior chamber angle and should allow surgeons who treat glaucoma to more accurately and safely perform angle-related procedures.
Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1 (2001)

In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor. X53BP1 transcripts are highly expressed in ovaries, and the protein interacts with Xp53 throughout the cell cycle in embryonic extracts. However, no interaction between X53BP1 and Xp53 can be detected in somatic cells, suggesting that the association between the two proteins may be developmentally regulated. X53BP1 is modified via phosphorylation in a DNA damage-dependent manner that correlates with the dispersal of X53BP1 into multiple foci throughout the nucleus in somatic cells. Thus, X53BP1 can be classified as a novel participant in the DNA damage response pathway. We demonstrate that X53BP1 and its human ortholog can serve as good substrates in vitro as well as in vivo for the ATM kinase. Collectively, our results reveal that 53BP1 plays an important role in the checkpoint response to DNA damage, possibly in collaboration with ATM.
Lateral confinement InGaAsP superluminescent diode at 1.3 µm (1983)

A superluminescent diode (SLD) has properties, based on the degree of coherence, that are bounded by those of the light emitting diode and the laser diode. The SLD can be designed to meet a wide range of optical system needs. By introducing ridge-waveguide lateral confinement, a good anti-reflection coating at one end and a high reflectivity mirror at the other, we have demonstrated an SLD that allows 30 percent coupling efficiency into a lensed 0.23 NA, 50 μm diameter graded index core fiber. The power in the fiber is 550 μW at 250 mA and 20°C. It is possible to maintain a constant power level in the fiber greater than 250 μW over the temperature range 0 to 35°C by adjusting the current. The spectral width is 300 Å and the modulation bandwidth 350 MHz. PCM with 400 Mbit/s rate has been observed. These devices are relatively easy to fabricate from ridge-waveguide lasers or any other lateral confinement laser.
Nuclear Magnetic Resonance Study of the Protolysis of Trimethylammonium Ion in Aqueous Solution—Order of the Reaction with Respect to Solvent (1963)

It was found previously that the proton-transfer reaction between trimethylammonium ion and trimethylamine in aqueous solution takes place via water. In the present investigation the number of water molecules involved in this reaction was determined. Proton exchange rates were determined from NMR measurements in trimethylamine—trimethylammonium chloride buffer solutions in O17-enriched water. It is concluded that one water molecule is involved in the transfer reaction. In the appendix, theoretical equations are derived for the dependence of the observed spin-echo decay rate on the 180° pulse rate for the case of fast exchange.
Comparing Visual Data Fusion Techniques Using FIR and Visible Light Sensors to Improve Pedestrian Detection (2011)

Pedestrian detection is an important field in computer vision with applications in surveillance, robotics and driver assistance systems. The quality of such systems can be improved by the simultaneous use of different sensors. This paper proposes three different fusion techniques to combine the advantages of two vision sensors -- a far-infrared (FIR) and a visible light camera. Different fusion methods taken from various levels of information representation are briefly described and finally compared regarding the results of the pedestrian classification.
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines. (1991)

The p53 tumor suppressor gene is frequently mutated and the K-ras oncogene is occasionally mutated in primary specimens of human lung carcinomas. These mutated genes also cooperate in the immortalization and neoplastic transformation of rodent cells. To determine whether these mutations are necessary for maintenance of the immortalized and/or neoplastically transformed states of human bronchial epithelial cells, the p53 gene and regions of the ras (K-, H-, and N-) genes were sequenced in nine human lung carcinoma cell lines. Detection of p53 mutations by polymerase chain amplification and direct DNA sequencing was corroborated by p53 immunocytochemistry and coimmunoprecipitation of p53 with heat shock protein 70. p53 and ras genes were frequently, but not always, mutated in the carcinoma cell lines. These data are consistent with the hypothesis that multiple genetic changes involving both protooncogenes and tumor suppressor genes occur during lung carcinogenesis.
Development of urease-chitosan membrane. (1990)

Urease was covalently immobilized on glutaraldehyde-pretreated chitosan membrane. The optimum immobilization conditions were determined with respect to glutaraldehyde pretreatment of membranes (concentration and pH of glutaraldehyde solution, time of membrane-glutaral-dehyde reaction) and to reaction of glutaraldehyde-pretreated membranes with urease (concentration and pH of urease solution). The obtained membrane has high enzymatic activity, and can be applied for enzymatic removal of urea e.g. in the treatment of chronic or acute uraemia.