gebhart/patrepeval huggingface dataset:
Synthesis of ring-fused pyrroles. I. 1,3-Dipolar cycloaddition reactions of munchnone derivatives obtained from tetrahydro-.beta.-carboline-3- and -1-carboxylic acids (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of ring-fused pyrroles. I. 1,3-Dipolar cycloaddition reactions of munchnone derivatives obtained from tetrahydro-.beta.-carboline-3- and -1-carboxylic acidsFred M. HershensonCite this: J. Org. Chem. 1972, 37, 20, 3111–3113Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/jo00985a016https://doi.org/10.1021/jo00985a016research-articleACS PublicationsRequest reuse permissionsArticle Views208Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bifunctional Core–Shell–Corona Particles for Amphiphobic Coatings (2011)

Bifunctional core–shell–corona particles that bore both fluorinated units and hydroxyl groups in the corona were synthesized. The core particles were prepared from monomer methyl methacrylate (MMA) and cross-linker ethylene glycol dimethacrylate (EGDMA). The shell was grown from MMA, EGDMA, and HEA-Cl [2-(2′-chloropropionato)ethyl acrylate] via seeded emulsion polymerization. The incorporated HEA-Cl groups initiated the atom-transfer radical polymerization of 2-hydroxyethyl acrylate (HEA) to produce a PHEA corona. Particles with both fluorinated units and hydroxyl groups in the corona were obtained after reacting ∼80% of the PHEA hydroxyl groups with perfluorononanoyl chloride. After casting trifluorotoluene dispersions of these particles onto a glass plate, the resultant coating was amphiphobic, possessing high contact angles for both water and diodomethane. For water, the advancing contact angle reached 165° and the advancing and receding angle difference (hysteresis) was small. Thus, the coating was superhydrophobic. More interestingly, the hydroxyl groups in the particle coronas could be used to bond with an epoxy glue, which adhered to glass substrate, to yield a “permanent” amphiphobic coating.
Long nuclear-retained non-coding RNAs and allele-specific higher-order chromatin organization at imprinted snoRNA gene arrays (2009)

The imprinted Snurf-Snrpn domain, also referred to as the Prader-Willi syndrome region, contains two approximately 100-200 kb arrays of repeated small nucleolar (sno)RNAs processed from introns of long, paternally expressed non-protein-coding RNAs whose biogenesis and functions are poorly understood. We provide evidence that C/D snoRNAs do not derive from a single transcript as previously envisaged, but rather from (at least) two independent transcription units. We show that spliced snoRNA host-gene transcripts accumulate near their transcription sites as structurally constrained RNA species that are prevented from diffusing, as well as multiple stable nucleoplasmic RNA foci dispersed in the entire nucleus but not in the nucleolus. Chromatin structure at these repeated arrays displays an outstanding parent-of-origin-specific higher-order organization: the transcriptionally active allele is revealed as extended DNA FISH signals whereas the genetically identical, silent allele is visualized as singlet DNA FISH signals. A similar allele-specific chromatin organization is documented for snoRNA gene arrays at the imprinted Dlk1-Dio3 domain. Our findings have repercussions for understanding the spatial organization of gene expression and the intra-nuclear fate of non-coding RNAs in the context of nuclear architecture.
Des-Asp-1-Angiotensin II: Possible Role in Mediating the Renin-Angiotensin Response in the Rat (1976)

Angiotensin II and its heptapeptide fragment, Des-Asp-1-angiotensin II, produced a striking increase in aldosterone secretion in rats pretreated with dexamethasone and morphine to reduce ACTH release. 1-Sar-8-Ala-angiotensin II (10 mug/kg min-1) given simultaneously with angiotensin II (1 mug/min) blocked the aldosterone response to angiotensin II in rats pretreated to reduce ACTH release. In contrast, 1-Sar-8-Ala-angiotensin II at the same dose failed to block the steroid response to Des-Asp-1-angiotensin II (1 mug/min) but a larger dose of 50 mug/kg min-1 of the angiotensin II antagonist blocked completely both the aldosterone and the corticosterone responses to 1 mug/min of Des-Asp-1-angiotensin II. From these data it is suggested that the heptapeptide has a higher affinity for zona glomerulosa receptors than the octapeptide and that Des-Asp-1-angiotensin II mediates, at least in part, the steroidogenic response to the renin-angiotensin system in the rat. The pressor response to Des-Asp-1-angiotensin II was approximately 50% of that produced by the octapeptide in the rat, and 1-Sar-8-Ala-angiotensin II was as effective in partially blocking the pressor response to the octapeptide as in inhibiting the heptapeptide. The present observations indicate a dissociation of adrenal cortex and peripheral arteriolar receptors in their affinity for angiotensin.
Maximizing time-dependent spectrum sharing between neighbouring channels in CO-OFDM optical networks (2011)

For CO-OFDM-based networks, we develop an efficient wavelength indexing algorithm to maximally share optical spectrum between neighbouring channels through properly arranging lightpaths that have good match of spectrum usage as neighbours in the optical spectrum. Simulation studies indicated that the proposed algorithm can achieve much better optical spectrum efficiency than the conventional wavelength assignment algorithms such as random and first-fit algorithms, no matter under a single-link or an irregular mesh-network case.
Donald P. Cole, <u>Nomads of the Nomads : The Al Murrah Bedouin of the Empty Quarter</u> (Chicago: Aldine-Atherton, Inc., 1975). Pp. 179. $7.50 cloth or $2.95 paper. (1976)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
The damaging action of cellular immunity in flavivirus infections of mice. (1975)

The development of acute infections caused by different flaviviruses was studied in immunosuppressed inbred and non-inbred mice. Cyclophosphamide treatment of challenged animals resulted in an increase of the mean survival time by 24--144 hours in some but not all virus-mouse strain combinations. The transient protective action of cyclophosphamide was not due to suppression of the reproduction of tick-borne encephalitis (TBE) or dengue 2 (D2) virus in the brains of mice. In TBE or D2 infections of immunosuppressed mice the clinical signs of central nervous system lesions seemed to be associated with the development of cellular immunity measured by the splenobyte migration inhibition test. The transfer of sensitized splenocytes in immunosuppressed animals, challenged with TBE or D2 virus, shortened the incubation period. These results suggest that cellular immunity may have a damaging effect in acute flavivirus infections in mice, and also that the immunopathological response varies considerably in different strains of inbred mice.
Ordered statistic CFAR technique - an overview (2011)

Adaptive radar target detection in a noise or clutter environment is a very important device in each radar receiver. In almost all detection procedures the received echo signal amplitude is simply compared with a certain threshold. The main objective in target detection is to maximize the target detection probability under the constraints of very low and Constant False Alarm Rate (CFAR). The noise and clutter background will be described by a statistical model with e.g. independent and identically Rayleigh or exponentially distributed random variables of known average noise power. But in practical applications this average noise or clutter power is absolutely unknown and can additionally vary over range, time and azimuth angle. Therefore this paper describes some of the so-called range CFAR techniques for several different background signal situations in which the average noise power and some other additional statistical parameter are assumed to be unknown. All range CFAR techniques combine therefore an estimation procedure (to get precise or estimated knowledge about the noise power) and a decision step by applying an amplitude threshold to the echo signal amplitude inside the test cell. This general detection scheme has been analysed in many research activities and a large effort has been spent on this topic. The objective of this paper is to give a short characterisation and technical comparison of some of these important range CFAR detection schemes. © 2011 DGON.
Enhancing Effect of Autoclaving on Bioactivity of ß-Titanium Alloy Coated with Calcium Phosphate Glass-Ceramic (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Complex Response of a Rocking Block to a Full-Cycle Pulse (2013)

The rocking response of rigid, free-standing bodies to earthquake pulses is revisited. A two-dimensional rectangular block resting on a rigid base is considered, subjected to an idealized ground acceleration pulse composed of two constant half-cycles of equal amplitude, equal duration, and opposite sign. Closed-form expressions are obtained for the dynamic response, whereas rigorous overturning criteria are established for conditions with and without impact. The solutions are expressed in terms of three dimensionless parameters, namely, pulse duration, uplift strength, and restitution coefficient. Despite the apparent simplicity of the problem, the response can exhibit complex—even counterintuitive—patterns, a trait attributed to the possibility of overturning in two distinct modes (forward and backward), the nonlinear nature of the impact, the real-valued (positive) pole of the differential operator, and the presence of multiple immobility points in a particular response branch. The bifurcation behavior associated with the existence of two overturning modes is highlighted. Comparisons against idealized pulses of other shapes and actual near-fault recorded ground motions are presented and commented.
Terodiline in the treatment of urinary frequency and motor urge incontinence. A controlled multicentre trial. (1984)

Terodiline is a secondary amine with antimuscarinic and calcium antagonistic properties. It has complete bioavailability from the gastro-intestinal tract and a mean elimination half-life of 60 hours. This paper describes a randomized, double-blind, two period cross-over (3 week periods) trial in women with motor urge incontinence without other neurological symptoms. The drug was given b.i.d., 12.5 mg in the morning and 25 mg at night. The trial was performed as a multicentre study and monitored by frequent site visits during the 9 months when patients entered the study. Eighty-nine patients from 19 clinics fulfilled the inclusion criteria of the protocol. Cystometrograms (CMG) (bladder capacity, volume at first desire to void, residual urine) and micturition characteristics over 3 to 7 days were measured during a one week run-in period and during the last week of each treatment period. The patients' preferences were assessed for the two treatment periods as well as vis-à-vis the run-in period. Side effects were evaluated at the end of each treatment period. There were 16 drop-outs and withdrawals during period 1 and 9 during period 2 (5 and 3 due to cystitis, 7 and 2 due to side effects, and 4 and 4 lost to follow up, respectively). During the evaluation of the data a treatment by period interaction was observed which motivated a parallel group analysis to be performed in addition to a cross-over trial analysis. Statistically significant differences in patient preferences were demonstrated (63% preferred terodiline in comparison with placebo and 69% terodiline in comparison with run-in). No statistically significant difference in incidence of side effects could be demonstrated between terodiline and placebo. Based on all data available 35% of the patients had side effects on placebo and 53% on terodiline. Twelve per cent reported dryness of the mouth on placebo and 25% on terodiline. Of the 9 patients (10%) withdrawn from the study because of side effects, 7 had terodiline as first treatment, one had placebo and one terodiline as second treatment. The frequency of voluntary micturitions decreased during period 1 from 9.6 to 8.9 (-0.7) per 24 hours on placebo and from 9.9 to 7.3 (-2.6) on terodiline. Involuntary micturitions decreased from 2.3 to 1.7 (-0.6) on placebo and from 2.5 to 1.5 (-1.0) on terodiline. The changes during terodiline were statistically significant.(ABSTRACT TRUNCATED AT 400 WORDS)
Public policy and the evolution of the labour market in Sri Lanka (1986)

This paper examines the evolution of labor market conditions in the recent economic development of Sri Lanka, with special attention to the effects of various government policies. Three facts about the Sri Lankan labor market stand out: (i) a very low rate of urbanization; (ii) modest structural changes in the labor market; and (iii) a high standard of living in relation to gross national product (GNP). The derived demand for labor has changed little, because the structure of production has changed little. A variety of Governmental policies, which include macreconomic policy, social welfare policy, labor market and sectoral policy, have left the existing labor market structure largely intact. Looking ahead, the paper finds, that it would not be at all surprising to find that the labor market will evolve as little in the next decade as it has in the past years.
Train locator using inertial sensors and odometer (2004)

The paper describes a solution to railway vehicle localization problem for the cases, where no global positioning information (like GPS) is temporarily unavailable. The given solution also assumes no additional landmarks or other extraordinary installations aside the train track. The presented approach is based on smart fusion of onboard-gathered data making use of Kalman filter. The available data sources include a vehicle odometer and accelerometer.
On the Mechanism of the Photographic Effect of Ultrasonic Waves (1953)

Experimental data are submitted indicating the existence of a direct action of ultrasonic waves on a photographic emulsion, contrary to the views of some other workers. All of the evidence obtained here indicates a closer correlation with the softness of the emulsion than with the known behavior of ultrasonically produced luminescence. Information is presented as to temperature dependence of the image, effect of ambient pressure, light shielding, and the behavior of various types of commercial emulsions.
Solubility Behavior of CO<sub>3</sub>Apatites in Relation to Crystallinity (1981)

To study the susceptibility of carbonate-containing apatites to caries, synthetic CO3 apatites with various crystallinities and carbonate contents were prepared at 40, 60 and 80 °C. The crystallinity of CO3 apatites decreased with carbonate content and increased with temperature. The apparent solubility of CO3 apatites over pH 4–8 at 37 °C was related approximately to their crystallinity. In particular, the degree of increase in the solubility of CO3 apatites synthesized at 80 °C and thus having high crystallinity changed greatly in the region of 0–3 wt% of carbonate content, which approximates to that of enamel apatites. The relationship between solubility and crystallinity obtained in this study may be a useful indicator of the susceptibility of carbonate-containing apatites to acid.
Differential activity of TGF-beta2 on the expression of p27Kip1 and Cdk4 in actively cycling and contact inhibited rabbit corneal endothelial cells. (2001)

These data suggest that Cdk4 and p27 expression is density dependent, and TGF-beta2 exerted its activity on actively cycling cells. In these cells, TGF-beta2 downregulated Cdk4 expression and prevented the phosphorylation of p27, which is a prerequisite for nuclear export of the inhibitor molecule for degradation. Thus, TGF-beta2 inhibits the G1/S transition while it maintains p27 in an active form in the nuclei during the exponential growth cell stage.
Cell Transplantation for the Treatment of Acute Myocardial Infarction Using Vascular Endothelial Growth Factor–Expressing Skeletal Myoblasts (2001)

Background Vascular endothelial growth factor (VEGF) is a promising reagent for inducing myocardial angiogenesis. Skeletal myoblast transplantation has been shown to improve cardiac function in chronic heart failure models by regenerating muscle. We hypothesized that transplantation of VEGF-expressing myoblasts could effectively treat acute myocardial infarction by providing VEGF-induced cardioprotection through vasodilatation in the early phase, followed by angiogenesis effects in salvaging ischemic host myocardium combined with the functional benefits of newly formed, skeletal myoblast-derived muscle in the later phase. Methods and Results Primary rat skeletal myoblasts were transfected with the human VEGF 165 gene using hemagglutinating virus of Japan-liposome with >95% transfection efficiency. Four million of these myoblasts (VEGF group), control-transfected myoblasts (control group), or medium only (medium group) was injected into syngeneic rat hearts 1 hour after left coronary artery occlusion. Myocardial VEGF-expression increased for 2 weeks in the VEGF group, resulting in enhanced angiogenesis without the formation of tumors. Grafted myoblasts had differentiated into multinucleated myotubes within host myocardium. Infarct size (33.3±1.4%, 38.1±1.4%, and 43.7±1.6% for VEGF, control, and medium groups, respectively; P =0.0005) was significantly reduced with VEGF treatment, and cardiac function improved in the VEGF group (maximum dP/dt: 4072.0±93.6, 3772.5±101.1, and 3482.5±90.6 mm Hg/s in the 3 groups, respectively; P =0.0011; minimum dP/dt: −504.2±68.5, −2311.3±57.0, and −2124.0±57.9 mm Hg/s, respectively; P =0.0008). Conclusions This combined strategy of cell transplantation with gene therapy could be of importance for the treatment of acute myocardial infarction.
An adaptive document retrieval system using a neural network (1990)

Current document retrieval systems based on keyword retrieval have many problems with regard to human‐computer interaction. This paper focuses on three of them: (a) Not only the inputted keywords but also their relations have much important information as a representation of his query, though the system ignores the relations and uses them as indices of documents. (b) As a word can be understood in various ways by different people, one query can represent as various sets of keywords.(c) A user who does not have enough knowledge about his target field may fail to represent his query as a set of the keywords. A document retrieval system that overcomes these drawbacks is presented. The system has three major characteristics corresponding to the above problems: (a) It can extract the feature between keywords by representing the user's query as an activation pattern over a neural network, and retrieve documents by considering the relation between the inputted keywords. (b) It can be adapted to each user, and specify each user's query. (c) It is cooperative: Through a dialogue with a computer, a user can receive information that may help to make his query more specific, and the system can thereby improve the retrieved results. A user, even if he has little knowledge about his target, starts the retrieval process by inputting keywords that occur to him. Then, through a dialogue between the system, which presents the information, and the user, who evaluates this information, the system adapts to the user, and his query becomes more apparent. Finally, the system presents documents and keywords appropriate for each user's query.
Law School: Legal Education in America from the 1850s to the 1980s by Robert Stevens. Chapel Hill (1984)

"Law School: Legal Education in America from the 1850s to the 1980s by Robert Stevens. Chapel Hill." Change: The Magazine of Higher Learning, 16(3), pp. 60–61
A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus (2006)

The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be. Our hypothesis is that they help the dentate gyrus to avoid the problem of catastrophic interference when adapting to new environments. We assume that old neurons are rather stable and preserve an optimal encoding learned for known environments while new neurons are plastic to adapt to those features that are qualitatively new in a new environment. A simple network simulation demonstrates that adding new plastic neurons is indeed a successful strategy for adaptation without catastrophic interference.
The Evaluation of a Low-Cost Colorimeter for Glucose Detection in Salivary Samples (2017)

Given the limited access to healthcare resources, low-income settings require the development of affordable technology. Here we present the design and evaluation of a low-cost colorimeter applied to the non-invasive monitoring of <i>Diabetes Mellitus</i> through the detection of glucose in salival fluid. Samples were processed by the glucose oxidase-peroxidase enzymatic system and analyzed with the development equipment. A light emission diode of 532.5 nm was used as an excitation source and a RGB module was used as a receptor. A calibration curve to quantify the concentration of salivary glucose (0 to 18 mg/dL) was carried out by relating the RGB components registered with glucose concentrations, achieving a limit of detection of 0.17 mg/dL with a CV of 5% (n = 3). Salivary samples of diabetic and healthy volunteers were processed with the equipment showing an average concentration of 1.5519 ± 0.4511 mg/dL for the first and 4.0479 ± 1.6103 mg/dL for the last, allowing a discrimination between both groups. Results were validated against a UV-Vis-NIR spectrophotometer with a correspondence of R² of 0.98194 between both instruments. Results suggest the potential application of the developed device to the sensitive detection of relevant analytes with a low-cost, user-friendly, low-power and portable instrumentation.