gebhart/patrepeval huggingface dataset:
A study of the performance and chemical characteristics of composite reverse osmosis membranes prepared by plasma polymerization of allylamine (1975)

Abstract A study has been carried out of the performance and chemical characteristics of composite reverse osmosis membranes prepared by plasma polymerization of allylamine in a radio‐frequency electric discharge. It has been shown that membranes can be prepared which simultaneously exhibit a high rejection for sodium chloride and a high water flux. The primary factors influencing the quality of the membranes are the choice of substrate material, the deposition time, and the power supplied to the discharge. Variations in rejection and flux as a function of applied pressure indicate that water flows through the membrane by both diffusive and bulk flow. A reduction in rejection and an increase in flux are observed when membranes are operated for prolonged periods or at higher temperatures (up to 60°C). Elemental analysis of plasma‐polymerized allylamine shows that it can be represented by the stoichiometry C 3 H 3.8 N 0.9 O 0.1 . Infrared spectra show evidence for NH, CN, CN, and CH bond vibrations. ESCA spectra of the polymer surface show that the surface contains substantial amounts of both nitrogen and oxygen and that the nitrogen is present as either a nitrile or an imine group but not as an amine group. ESCA spectra of membranes used for reverse osmosis show that the surface loses nitrogen and gains oxygen with time and that this phenomenon is accelerated at higher operating temperatures. A decrease in rejection and an increase in flux accompanies these changes. It is postulated that most of the nitrogen in the polymer is present in the form of RR′CNH or RR′CNR″ type structures. The loss of nitrogen and gain in oxygen observed in the ESCA spectra of membranes run at elevated temperatures is explained by the hydrolysis of the proposed structures.
Gas chromatography (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas chromatographyStuart P. Cram, Terence H. Risby, Larry R. Field, and Wei-Lu. YuCite this: Anal. Chem. 1980, 52, 5, 324–360Publication Date (Print):April 1, 1980Publication History Published online1 May 2002Published inissue 1 April 1980https://pubs.acs.org/doi/10.1021/ac50055a030https://doi.org/10.1021/ac50055a030research-articleACS PublicationsRequest reuse permissionsArticle Views648Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
EPDM Synthesis by the Ziegler Catalyst Cp*TiMe3/B(C6F5)3 (2001)

The utilization of the Ziegler catalyst Cp*TiMe3/B(C6F5)3 for the terpolymerization of ethylene, propylene and 5-ethylidene-2-norbornene to give EPDM is investigated, and the major factors affecting yields, molecular weights, molecular weight distributions and compositional distributions of the EPDM polymers are assessed. High molecular weight polymers with narrow molecular weight distributions are obtained at ˜18°C.
Bayesian sensitivity analysis for <i>E</i>. <i>coli</i>. (2016)

<p>Pairwise parameter PDFs are shown using scatter plots in off-diagonal panels; Monte Carlo sampled points illustrate the extent of the PDFs in the space of parameter values indicated on the x- and y-axes. Panels in transposed positions within the grids contain identical information with the x- and y-axes swapped. PDFs for individual parameters are shown on the diagonals using histograms, with the number of counts in each bin (out of 10<sup>6</sup> total samples) indicated on the y-axis.</p>
High Dynamic Range Image Reconstruction using Multiple Images (2008)

The dynamic range of image sensors is limited due to the capacitance of photodiode and the nonlinearity of the system response function. In this paper, the high dynamic range image reconstruction algorithm using multiple images is proposed. The proposed algorithm simultaneously enhances dynamic range and estimates the imaging system’s response function. The image acquisition process including limited dynamic range is modelled. With the observation model, the linear least squares estimates the response function of the imaging system as well as the single high dynamic range image are obtained.
Immunogold labeling of stages of Cryptosporidium parvum recognized by immunoglobulins in hyperimmune bovine colostrum. (1991)

Ultrathin sections of mouse ileum infected with Cryptosporidium parvum were stained by immunogold techniques. Sections first were stained with polyvalent antibodies in whey from hyperimmune bovine colostrum (HBC), then stained by secondary antibodies in rabbit antibovine IgA, IgM, IgG1, and IgG2, and lastly labeled by goat anti-rabbit gold conjugate. Examination of the immunostained specimens by electron microscopy revealed that each bovine immunoglobulin isotype in the whey recognized antigens in meronts, merozoites, microgametocytes, microgametes, and macrogamonts. Based on these findings it is hypothesized that antigens in all stages of C. parvum provide targets of opportunity for the antiparasitic activity of HBC whey antibodies thereby accounting for its efficacy as an immunotherapeutic agent.
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism (2013)

The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression of Alzheimer's disease, but the molecular pathways that control pathological aggregation have proved challenging to identify. Here, we use a combination of kinetic studies, selective radiolabeling experiments, and cell viability assays to detect directly the rates of formation of both fibrils and oligomers and the resulting cytotoxic effects. Our results show that once a small but critical concentration of amyloid fibrils has accumulated, the toxic oligomeric species are predominantly formed from monomeric peptide molecules through a fibril-catalyzed secondary nucleation reaction, rather than through a classical mechanism of homogeneous primary nucleation. This catalytic mechanism couples together the growth of insoluble amyloid fibrils and the generation of diffusible oligomeric aggregates that are implicated as neurotoxic agents in Alzheimer's disease. These results reveal that the aggregation of Aβ42 is promoted by a positive feedback loop that originates from the interactions between the monomeric and fibrillar forms of this peptide. Our findings bring together the main molecular species implicated in the Aβ aggregation cascade and suggest that perturbation of the secondary nucleation pathway identified in this study could be an effective strategy to control the proliferation of neurotoxic Aβ42 oligomers.
Comparative Analysis of LPCC, MFCC and BFCC for the Recognition of Hindi Words using Artificial Neural Networks (2014)

Most important way of communication among humans is language and primary medium used for the said is speech. The speech recognizers make use of a parametric form of a signal to obtain the most important distinguishable features of speech signal for recognition purpose. In this paper, Linear Prediction Cepstral Coefficient (LPCC), Mel Frequency Cepstral Coefficient (MFCC) and Bark frequency Cepstral coefficient (BFCC) feature extraction techniques for recognition of Hindi Isolated, Paired and Hybrid words have been studied and the corresponding recognition rates are compared. Artifical Neural Network is used as back end processor. The experimental results show that the better recognition rate is obtained for MFCC as compared to LPCC and BFCC for all the three types of words.
Effects of site‐directed mutagenesis on the serine residues of human lecithin: Cholesterol acyltransferase (1994)

Lecithin:cholesterol acyltransferase (LCAT) is a serine protease-type enzyme that esterifies cholesterol in human plasma and is activated by apolipoprotein A-I in high-density lipoproteins. LCAT contains 22 serine residues, including Ser181, which is thought to be part of the catalytic site. In order to determine the importance of these serine residues in LCAT, we prepared six LCAT mutants: LCAT (Ser19-->Ala), LCAT (Ser181-->Gly), LCAT (Ser208-->Ala), LCAT (SEr216-->Ala), LCAT (Ser225-->Ala) and LCAT (Ser383-->Ala). We also replaced the adjacent asparagine residues in two additional mutants, LCAT (Ser19-->Ala, Asn20-->Thr) and LCAT (Ser383-->Ala, Asn384-->Thr), in order to ascertain the effect of the serines on N-glycosylation. The mutant complementary DNA (cDNA) were subcloned into a eukaryotic expression vector (pSG5) and expressed in COS-6 cells. By polymerase chain reaction analysis, LCAT-specific messenger RNA (mRNA) was found in all mutant and wild-type transfectants. Western blot analysis revealed LCAT-specific bands in media and lysates of the transfected cells. With two exceptions, the amounts of LCAT mass secreted by the transfectants were similar to that of the wild type (mean, 90% mass of wild type; range, 34-138%). Except for LCAT (Ser181-->Gly), which was inactive, the specific activities of the remainder of the mutant enzymes were also similar (mean 95% activity of wild type; range, 65-169%). These results indicate that Ser181 is part of the catalytic site and that stereoconservative substitutions for serines have minor effects on the synthesis, secretion and specific activities of human LCAT.
Functional Electrical Stimulation by Nanogenerator with 58 V Output Voltage (2012)

We demonstrate a new type of integrated nanogenerator based on arrays of vertically aligned piezoelectric ZnO nanowires. The peak open-circuit voltage and short-circuit current reach a record high level of 58 V and 134 μA, respectively, with a maximum power density of 0.78 W/cm(3). The electric output was directly applied to a sciatic nerve of a frog, inducing innervation of the nerve. Vibrant contraction of the frog's gastrocnemius muscle is observed as a result of the instantaneous electric input from the nanogenerator.
Rational Functionalization of Carbon Nanotubes Leading to Electrochemical Devices with Striking Applications (2008)

Abstract As one‐dimensional carbon nanostructures, carbon nanotubes (CNTs) are a member of the carbon family but they possess very different structural and electronic properties from other kinds of carbon materials frequently used in electrochemistry, such as glassy carbon, graphite, and diamond. Although the past decade has witnessed rapid and substantial progress in both the fundamental understanding of CNT‐oriented electrochemistry and the development of various kinds of electrochemical devices with carbon nanotubes, the increasing demand from both academia and industry requires CNT‐based electrochemical devices with vastly improved properties, such as good reliability and durability, and high performance. As we outline here, the smart functionalization of CNTs and effective methods for the preparation of devices would pave the way to CNT‐based electronic devices with striking applications.
A Study of High Speed Digital Automatic Gain Control System (1994)

According to special requirements of airborne pulse doppler radar to high speed range cell gain control,a new high speed digital automatic gain control system has been developed,The principle and excellence of this system have been introduced,some important points in the circuit design have been discussed too.
Genetic Testing for Cancer Predisposition (2001)

Clinical cancer genetics is becoming an integral part of the care of cancer patients. This review describes the clinical aspects, genetics, and clinical genetic management of most of the major hereditary cancer susceptibility syndromes. Multiple endocrine neoplasia type 2, von Hippel-Lindau disease, and familial adenomatous polyposis are examples of syndromes for which genetic testing to identify at-risk family members is considered the standard of care. Genetic testing for these syndromes is sensitive and affordable, and it will change medical management. Cancer genetic counseling and testing is probably beneficial in other syndromes, such as the hereditary breast cancer syndromes, hereditary nonpolyposis colorectal cancer syndrome, Peutz-Jeghers syndrome, and juvenile polyposis. There are also hereditary cancer syndromes for which testing is not yet available and/or is unlikely to change medical management, including Li-Fraumeni syndrome and hereditary malignant melanoma. Thorough medical care requires the identification of families likely to have a hereditary cancer susceptibility syndrome for referral to cancer genetics professionals.
A normally-closed, bimetallically actuated 3-way microvalve for pneumatic applications (2002)

A new normally-closed 3-way microvalve for pneumatic applications is presented for the first time. The valve is driven by a bimetallic actuation principle. This paper discusses the dimensioning and design, the fabrication and the experimental results of the 3-way valve. The valve is designed to control differential pressures of 1000 kPa. Flow rates up to 800 ml/min for dry air at 600 kPa can be achieved. The power consumption is about 1 W. The valve has been tested successfully in an ambient temperature range from 0 to 50/spl deg/C.
Synthesis and Characterization of Mono- and Bis-methano[60]fullerenyl Amino Acid Derivatives and Their Reductive Ring-Opening Retro-Bingel Reactions (2002)

The addition of N-(diphenylmethylene)glycinate esters (Ph2C=NCH2CO2R) 3-6 to [60]fullerene under Bingel conditions gives, respectively, the methano[60]fullerenyl iminoesters 7-10. Upon treatment of 7-9 with sodium cyanoborohydride, in the presence of a protic or a Lewis acid, a novel reductive ring-opening reaction occurred to give the corresponding 1,2-dihydro[60]fullerenyl glycine derivatives 11-13. Using tethered bis-N-(diphenylmethylene)glycinate esters 33 and 34derived from m- and p-benzenedimethanol scaffolds, the corresponding bis-methano[60]fullerenyl iminoesters 35-38 were synthesized under double Bingel reaction conditions. The m-benzenedimethanol derivative 33 gave the trans-4 (35) and cis-3 (36) regioisomeric bisadducts in a ratio of 80:20. The analogous para-tethered derivative 34 afforded the trans-3 (37) and trans-4 (38) regioisomers in a 80:20 ratio. The regiochemistry of the major bisadducts 35 and 37 (via the trans-esterified 39) were unequivocally determined using 2D INADEQUATE and C-C TOCSY NMR experiments. The regiochemistry of these bis-additions were unexpected on the basis of literature precedents. These results unequivocally show that the regiochemistry of tethered bis-additions is not solely dependent on the nature of the tether. A mixture of the trans-4 and cis-3 nonsymmetrical bisadducts 45 and 46 was obtained from the double-Bingel cyclopropanation of a bis-N-(diphenylmethylene)glycinate tether based on a 1,3-naphthyldimethanol scaffold. The regiochemistry of these compounds (45 and 46) was identified by correlation with the diethyl esters 40 and 47, prepared by trans-esterification of 35/45 and 36/46, respectively. The INADEQUATE and molecular modeling experiments allowed topological mapping of the fullerene surfaces of the bis-methano[60]fullerenes 38 and 42. Reductive ring-opening reactions on the tethered bis-methano[60]fullerenes 35-37, 45, and 46 gave none of the expected bis-fullerenylglycinates rather the reductive ring-opening-retro-Bingel products, the 1,2-dihydro[60]fullerenylglycinates 48, 49, 52, and 53. These compounds resulted from the reductive ring-opening of one methanoimino ester moiety and a retro-Bingel reaction of the other. Under analogous reductive ring-opening-retro-Bingel conditions, the nontethered bis-methano[60]fullerene 40 afforded the 1,2-dihydro[60]fullerenylglycinate 12. Thus, it was concluded that the tether was not the driving force for the reductive elimination of one of the methano groups.
Mechanisms for Intragenic Complementation at the Human Argininosuccinate Lyase Locus (2001)

Argininosuccinate lyase (ASL) is a homotetrameric enzyme that catalyzes the reversible cleavage of argininosuccinate to arginine and fumarate. Deficiencies in the enzyme result in the autosomal, recessive disorder argininosuccinic aciduria. Considerable clinical and genetic heterogeneity is associated with this disorder, which is thought to be a consequence of the extensive intragenic complementation identified in patient strains. Our ability to predict genotype-phenotype relationships is hampered by the current lack of understanding of the mechanisms by which complementation can occur. The 3-dimensional structure of wild-type ASL has enabled us to propose that the complementation between two ASL active site mutant subunits, Q286R and D87G, occurs through a regeneration of functional active sites in the heteromutant protein. We have reconstructed this complementation event, both in vivo and in vitro, using recombinant proteins and have confirmed this hypothesis. The complementation events between Q286R and two nonactive site mutants, M360T and A398D, have also been characterized. The M360T and A398D substitutions have adverse effects on the thermodynamic stability of the protein. Complementation between either the M360T or the A398D mutant and the stable Q286R mutant occurs through the formation of a more stable heteromeric protein with partial recovery of catalytic activity. The detection and characterization of a novel complementation event between the A398D and D87G mutants has shown how complementation in patients with argininosuccinic aciduria may correlate with the clinical phenotype.
O Bellvm Africvm e a construção da imagem do Imperator Júlio César (2008)

Este artigo apresenta a imagem de Caio Julio Cesar como imperator, construida de forma idealizada, revelando ensejos de propaganda politica, na obra intitulada Bellum Africum.
A framework for fast quantum mechanical algorithms (1997)

A framework is presented for the design and analysis of quantum mechanical algorithms, the sqrt(N) step quantum search algorithm is an immediate consequence of this framework. It leads to several other search-type applications - several examples are presented. Also, it leads to quantum mechanical algorithms for problems not immediately connected with search - two such algorithms are presented for estimating the mean and median of statistical distributions. Both algorithms require fewer steps than the fastest possible classical algorithms; also both are considerably simpler and faster than existing quantum mechanical algorithms for the respective problems.
Designing Communication Protocols for a Computer-Mediated Laboratory for Problem-Based Learning. (1990)

Abstract
This paper describes some of the design criteria for a facility to support problem-based tutorials, known as the Computer-Mediated Tutorial Laboratory (CMTL). In the CMTL, a networked workstation will be provided for the tutor and each of the students. The tutor's workstation will be connected to a projection system, permitting the entire group to view the tutor's screen. The software used in the CMTL will have three components: a Patient Simulation Stack (PSS), the group/student Tutorial Stacks (TSs) and the network communication interface. The PSS represents a clinical problem; it is designed to realistically simulate an encounter with an actual patient. The TSs serve as a personalized record of what transpired in the tutorial session. Each student will maintain a private TS and the tutor will maintain a shared TS, viewable by all members of the group. The network communication interface will permit the participants in the tutorial to direct electronic messages to each other. The communication interface has two components: the client software available on the student's and tutor's workstation and the server software. The CMTL client software consists of two applications-one for sending messages and one for viewing the stream of incoming messages. Research is planned to investigate the effects of computer-mediation on the tutorial process.
The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of<i>Toxoplasma gondii</i> (2012)

Toxoplasma gondii uses specialized secretory organelles called rhoptries to deliver virulence determinants into the host cell during parasite invasion. One such determinant called rhoptry protein 18 (ROP18) is a polymorphic serine/threonine kinase that phosphorylates host targets to modulate acute virulence. Following secretion into the host cell, ROP18 traffics to the parasitophorous vacuole membrane (PVM) where it is tethered to the cytosolic face of this host-pathogen interface. However, the functional consequences of PVM association are not known. In this report, we show that ROP18 mutants altered in an arginine-rich domain upstream of the kinase domain fail to associate to the PVM following secretion from rhoptries. During infection, host cells upregulate immunity-related GTPases that localize to and destroy the PVM surrounding the parasites. ROP18 disarms this host innate immune pathway by phosphorylating IRGs in a critical GTPase domain and preventing loading on the PVM. Vacuole-targeting mutants of ROP18 failed to phosphorylate Irga6 and were unable to divert IRGs from the PVM, despite retaining intrinsic kinase activity. As a consequence, these mutants were avirulent in a mouse model of acute toxoplasmosis. Thus, the association of ROP18 with the PVM, mediated by its N-terminal arginine-rich domain, is critical to its function as a virulence determinant.
Integrated Serum and Fecal Metabolomics Study of Collagen-Induced Arthritis Rats and the Therapeutic Effects of the Zushima Tablet (2018)

The Zushima tablet (ZT) has been used for decades in the clinical treatment of rheumatoid arthritis (RA) in China. However, its therapeutic mechanism is unclear. In this study, we aimed to explore the distinctive metabolic patterns in collagen-induced arthritis (CIA) rats and evaluate the therapeutic effects of ZT on RA using untargeted serum and fecal metabolomics approaches based on gas chromatography coupled with mass spectrometry. Body weight, hind paw swelling, TNF-α and IL-1β levels, arthritis scores, and histopathological parameters were assessed. In the metabolomics study, 31 altered metabolites in the serum and 30 in the feces were identified by comparing the model with the control group using statistical processing. These altered metabolites revealed that the tricarboxylic acid cycle, glycolysis metabolism, fatty acid metabolism, and purine metabolism were disturbed in CIA rats, and most of these altered metabolites including l-isoleucine, l-aspartic acid, pyruvic acid, cholic acid, and hypoxanthine, were rectified by ZT. Furthermore, short-chain fatty acids in feces were quantitatively determined, and the results showed that ZT could regulate the levels of propionate, butyrate, and valerate in CIA rats. Then, gut microbiota were analyzed by 16S rRNA analysis. Our results showed that <i>Firmicutes</i> and <i>Bacteroidetes</i> were the most abundant bacteria in rats. The levels of 19 types of bacteria at the family level were altered in RA rats, and most of them could be regulated by ZT. This study demonstrated that metabolomics analysis is a powerful tool for providing novel insight into RA and for elucidating the potential mechanism of ZT.