gebhart/patrepeval huggingface dataset:
Cloud-assisted privacy-preserving genetic paternity test (2015)

The rapid development of the DNA sequencing has greatly decreased the costs in genome sequencing, leading to a high availability of genomic data in the near future. Based on these data, we can realize genomic medical treatment, disease prevention, personalized medicine, social network applications, and etc., which greatly facilitate our daily life. However, since one's genomic data is the ultimate identifier of an individual and contains huge amount of sensitive private information, such as disease predispositions and ancestry information, the use of genomic data may raise serious privacy concerns. In this paper, we focus on one important genomic data application: Paternity Test, which involves the whole DNA sequence (about 3 · 109 letters) and needs huge storage and computation. Considering genomic data user's privacy and the great storage and computing power of the public cloud, it is necessary to find ways of using genomic data in the cloud without disclosure and abuse of the individual's privacy. We first provide a general framework for storing and processing genomic data both in the cloud, then introduce the proposed privacy-preserving scheme for genetic paternity test with RSA's commutative encryption properties in public clouds without disclosure of users' genomic privacy. Our proposed scheme can achieve a higher privacy preserving level and outsource majority of computation to the public cloud. Performance evaluation shows the effectiveness and efficiency of our proposed scheme.
Impregnated Barium Dispenser Cathodes Containing Strontium or Calcium Oxide (1956)

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N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs (2014)

This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.
Reflection and transmission of radio waves at a continuously stratified plasma with arbitrary magnetic induction (1962)

A flexible theoretical model plas ma which can be deformed to fi t most mea s ured elect ron-ion-altitude profiles i. 3 e mployed t ogether wi th a va ila ble geophysical dat a on t he ionosphere to evahlate reflections and trans missions durin g quiescen t and disturbed propagation conditions. The refl ect ions and t ra ns mi ssions in t he ionospher e are determin ed rigorously with t he aid of th e classica l mag neto-ionic t heory . The complex indexes of r efr ac tion of t he medium are dedu ced, and a coupling in t he plas ma betwee n ordinar y a nd extraordinary, upgoing a nd down going mode of propagation is investigat ed . Th e corres ponding refl ection a nd t ransmi ssio n coeffici en ts are then ca lculated, a nd cer tain phenomena which can be exp ected as a r es ult o f the action of a solar di sturbance on t he r eflection process are predicted.
Influence of Structural Detailing on the Stability Behaviour of Truss Girders (2019)

ABSTRACT In the design of truss structures, stability verifications are often decisive. Especially flexural buckling is of relevant issue. Structural systems are therefore usually stabilised by means of constructional members and components. Depending on the stiffening system and loading, the torsional behaviour and lateral torsional buckling of members can be of importance as well. However, all conventional structures for stabilisation have in common that they in general provide a shear stiffness (by bracings or sheeting) as well as an elastic rotational support. The influence of different structural truss details are analysed with regard to the girder stability. In this context, the stiffness of bracing systems and its position as well as the influence of rotational stiffness provided by purlins are investigated. In doing so, individual truss girders are analysed as well as systems of several girders based on full three‐dimensional beam models. The investigations provide information on the global stability behaviour with respect to different girder quantities stabilized by one bracing system. Additionally, a subset of structural systems are modelled in more detail using shell elements in regions of connections/joints to account for structural detailing influences. Overall, the aim is to identify and focus different effects of structural details on the stability behaviour of lattice girders to promote an economic and safe design.
Inhibition of Crimean-Congo Hemorrhagic Fever Viral Infectivity Yields in Vitro by Ribavirin (1989)

Ribavirin was evaluated as a potential therapeutic for Crimean-Congo hemorrhagic fever (CCHF). Viral yields for strains of CCHF virus from Europe, Asia, and Africa in African green monkey kidney (Vero) cells were markedly reduced by this drug. Some CCHF viral strains appeared more sensitive than others, but in general, ribavirin doses as low as 5 micrograms/ml caused a transient reduction of viral yields. A further reduction in viral yields was induced by a dose of 25 micrograms/ml, and evidence of viral replication was not demonstrated in cells treated with 50 or 250 micrograms/ml. In contrast, a dose of ribavirin at least 9 times greater was required to induce a comparable inhibitory effect on the yields of Rift Valley fever virus, for which the drug has been shown to inhibit replication in monkeys and rodents.
Nanoantenna Design for THz-band Rectification (2006)

This paper proposes a new nanoantenna-design-procedure for single- as well as double-band, CMOS-compatible, room temperature THz rectifiers. The sensitivity of the THz sensors are optimized. In case of double band sensors the cross-talk is kept under control.
Probabilistic mapping of the antidystonic effect of pallidal neurostimulation: a multicentre imaging study (2019)

Deep brain stimulation of the internal globus pallidus is a highly effective and established therapy for primary generalized and cervical dystonia, but therapeutic success is compromised by a non-responder rate of up to 25%, even in carefully-selected groups. Variability in electrode placement and inappropriate stimulation settings may account for a large proportion of this outcome variability. Here, we present probabilistic mapping data on a large cohort of patients collected from several European centres to resolve the optimal stimulation volume within the pallidal region. A total of 105 dystonia patients with pallidal deep brain stimulation were enrolled and 87 datasets (43 with cervical dystonia and 44 with generalized dystonia) were included into the subsequent 'normative brain' analysis. The average improvement of dystonia motor score was 50.5 ± 30.9% in cervical and 58.2 ± 48.8% in generalized dystonia, while 19.5% of patients did not respond to treatment (<25% benefit). We defined probabilistic maps of anti-dystonic effects by aggregating individual electrode locations and volumes of tissue activated (VTA) in normative atlas space and ranking voxel-wise for outcome distribution. We found a significant relation between motor outcome and the stimulation volume, but not the electrode location per se. The highest probability of stimulation induced motor benefit was found in a small volume covering the ventroposterior globus pallidus internus and adjacent subpallidal white matter. We then used the aggregated VTA-based outcome maps to rate patient individual VTAs and trained a linear regression model to predict individual outcomes. The prediction model showed robustness between the predicted and observed clinical improvement, with an r2 of 0.294 (P < 0.0001). The predictions deviated on average by 16.9 ± 11.6 % from observed dystonia improvements. For example, if a patient improved by 65%, the model would predict an improvement between 49% and 81%. Results were validated in an independent cohort of 10 dystonia patients, where prediction and observed benefit had a correlation of r2 = 0.52 (P = 0.02) and a mean prediction error of 10.3% (±8.9). These results emphasize the potential of probabilistic outcome brain mapping in refining the optimal therapeutic volume for pallidal neurostimulation and advancing computer-assisted planning and programming of deep brain stimulation.
Analysis and design of microwave amplifiers employing field-emitter arrays (1993)

An analysis of the microwave ( f≳1 GHz) properties of field-emitter arrays (FEAs) and several representative medium power (10–100 W) microwave amplifiers employing FEAs is presented. The FEA analysis is limited to parallel-plate structures having discrete pointlike vertical emitter tips and gate apertures aligned to each tip. A transmission line analysis of wave propagation in this structure is presented and used to evaluate the geometries and materials needed for microwave operation. This analysis is used to investigate the performance capabilities and emitter requirements of both modulated-emission linear beam tubes and microdevices based on FEAs. Specific microtriode designs are used to investigate practical problems such as space charge and thermal effects. Competitive performance should be achievable in gated-emission linear beam tubes by using FEAs that perform at levels previously reported by several laboratories. Existing FEA technology (currents of 10 μA per emitter, transconductances of 1 μS per emitter, 1 μm oxide thickness, and 3 μm emitter spacing) is suitable for use in cavity klystrodes(r) at frequencies through 10 GHz, and in moderately bunched beam (bunch width of 180°), octave-bandwidth traveling-wave-tube applications through 3 GHz. Extending the operating frequency and/or reducing the bunch width will require a larger ratio of transconductance to current. Microtriodes operating at 10 GHz will benefit from a modified FEA structure and improved emitter performance. An extra acceleration electrode must be added above the gate aperture to alleviate problems due to space charge between the gate and collector, and the gate oxide thickness must be increased to at least 2 μm. A FEA incorporating these features and capable of producing 5 μS and 100 μA per emitter could generate 130 W from a 5-mm-wide device with 8.6 dB gain, 7% bandwidth, and 36% power added efficiency. To allow higher gain and wideband operation, the transconductance at a given current must be increased. A FEA capable of producing 5 μS at only 10 μA per emitter would result in a microtriode with more than 1 octave bandwidth, 45 W output power, 10 dB gain, and 34% power added efficiency. Anode-to-case temperature differences of less than 100 °C appear possible in this device if BeO is used as the dielectric.
Synthesis, Structure and Hypoxic Cytotoxicity of 3‐Amino‐1,2,4‐benzotriazine‐1,4‐dioxide Derivatives (2007)

A series of novel 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives were synthesized and screened for their in vitro cytotoxicity against promyelocytic leukemia HL-60, androgen-independent prostate tumor PC3, hepatocellular carcinoma Bel-7402, human esophagus tumor ECA-109, and human breast tumor MCF-7 cell lines in hypoxia and in normoxia. Most compounds showed higher cytotoxic activity both in hypoxia and in normoxia. Among them, compounds 61 and 62 showed more potent cytotoxic activity and hypoxic selectivity when compared to tirapazamine.
The profilin multigene family of maize: differential expression of three isoforms (1993)

Profilin is a small (12-15 kDa) actin- and phospholipid-binding protein previously known only from studies on animals and lower eukaryotes but recently identified as a birch pollen allergen. Here we have identified and characterized three members of the profilin multigene family from the plant Zea mays. Two cDNAs isolated from a maize pollen library (ZmPRO 1 and ZmPRO 3) each have a single, large open reading frame encoding a putative polypeptide 131 amino acids long with a predicted molecular weight of approximately 14 kDa. A third maize pollen cDNA (ZmPRO 2) has two in-frame translation initiation codons. Use of the first ATG would result in a polypeptide 137 amino acids long with a molecular weight of 14.8 kDa. The three maize profilins are highly homologous to each other (> 90% nucleotide and amino acid sequence identity) as well as other plant profilins but show far less similarity (30-40% amino acid sequence identity) to animal and lower eukaryote profilins. Multiple sequence alignments indicate that only nine residues are shared by all eukaryotic profilins examined. However, limited comparisons reveal domains in the NH2 and COOH termini that have a high degree of similarity suggesting functional conservation. The maize gene family size is estimated to contain three to six members based on Southern blot experiments with gene-specific and coding region probes. Northern blot analysis demonstrates that the three maize profilin cDNAs characterized here are utilized in a tissue-specific manner and are anther or pollen specific.
Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development (2015)

The global burden of type 2 diabetes is increasing worldwide, and successful treatment of this disease needs constant provision of new drugs. Twelve classes of antidiabetic drugs are currently available, and many new drugs are under clinical development. These include compounds with known mechanisms of action but unique properties, such as once-weekly DPP4 inhibitors or oral insulin. They also include drugs with new mechanisms of action, the focus of this review. Most of these compounds are in Phase 1 and 2, with only a small number having made it to Phase 3 at this time. The new drug classes described include PPAR agonists/modulators, glucokinase activators, glucagon receptor antagonists, anti-inflammatory compounds, G-protein coupled receptor agonists, gastrointestinal peptide agonists other than GLP-1, apical sodium-dependent bile acid transporter (ASBT) inhibitors, SGLT1 and dual SGLT1/SGLT2 inhibitors, and 11beta- HSD1 inhibitors.
An evaluation of mobile phone text input methods (2002)

The rapid growth of Short Message Service (SMS) text messaging is generating substantial commercial and research interest in fast and efficient text input methods for mobile devices. This paper presents an empirical study that compares three mobile phone text input techniques. The methods are 'multi-press input with timeout', 'multi-press input with a next button', and 'two-key'. The study shows that there is a significant speed difference, in words per minute (wpm), between the methods. The multi-press with next method provided the most rapid text input at 7.2 wpm, followed by multi-press with timeout at 6.4 wpm. The two-key method was the slowest at 5.5 wpm. These results are much slower than those predicted by Fitts' Law models reported in prior research. Subjective results regarding learnability, errors and efficiency showed no significant difference between the methods.
Apolipoprotein B(Arg3500—-Gln) allele specific polymerase chain reaction: large-scale screening of pooled blood samples. (1992)

A two-step polymerase chain reaction (PCR) method for the rapid detection of the apolipoprotein B(Arg3500----Gln) mutation in a mixture of pooled blood samples is described. In the first step PCR, a short gene fragment surrounding codon 3500 is amplified. Subsequently the reaction product is subjected to a second amplification in which a mutation-specific primer is used. A PCR product is generated only if the mutant sequence is present in the DNA pool. Individuals carrying the mutation can then be identified by PCR with mutagenic primers and MspI restriction typing, essentially as described by Hansen et al. (J. Lipid Res. 1991. 32: 1229-1233).
Automated software wrapping (2007)

As a software vendor, we initiated a project to migrate a centralized mainframe-based commercial software system to a CORBA-based distributed environment using a software wrapping technique so our customers could invoke the system remotely. Later, we decided to automate the wrapping process to make the system more flexible in order to accommodate different customers' requirements for accessing the system using different interfacing styles. The automated software wrapping technique is presented in this paper.
The development of room temperature LEDs and lasers for the mid‐infrared spectral range (2008)

Abstract There are many applications for mid‐infrared light sources which has stimulated intensive research into the physics and technology of narrow gap materials and devices. In this article we give an overview of the development of mid‐infrared LEDs and diode lasers being studied in our laboratory. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Size-Dependent Magnetism of EuS Nanoparticles (2008)

EuS nanoparticles were synthesized by solution-phase thermolysis of the diethylammonium salt of the anionic europium dithiocarbamate complex, [Eu(S2CNEt2)4]−. Oleylamine and triphenylphosphine were used as surfactants to prevent nanoparticle agglomeration and stabilize particle growth. By varying the synthetic parameters such as reaction temperature, heating time, and the [surfactant]:[precursor] ratio, nanoparticles of different sizes were obtained. The size-dependent magnetic properties of these nanoparticles were studied, and it was observed that a decrease in the ferromagnetic ordering temperature occurs with decreasing particle size.
Chronic ethanol administration impairs the binding and endocytosis of asialo-orosomucoid in isolated hepatocytes. (1987)

We have examined the effect of ethanol administration on receptor-mediated endocytosis of asialo-orosomucoid by isolated hepatocytes. Significantly less ligand was bound, internalized, and degraded by hepatocytes isolated from rats fed an ethanol diet for 5-7 weeks than by cells isolated from chow-fed or pair-fed controls. Reduced binding was shown to be primarily due to a decreased number of cell surface receptors rather than to a lowered affinity of the receptor for its ligand. This reduction in cell surface receptors resulted in a marked inhibition of internalization and degradation of ligand by hepatocytes from the ethanol-fed rats. In addition, a defect in the initial stages of receptor-ligand internalization was also indicated, since less surface-bound ligand was internalized and subsequently degraded in cells from the ethanol-treated animals as compared to controls. Rates of internalization and degradation of internalized ligand were, however, similar for all three groups, suggesting that neither degradation per se nor rate of delivery of internalized ligand to the lysosomes was affected by ethanol feeding. Receptor recycling was impaired in ethanol-fed rats, as indicated by a decrease in the binding site number after stimulation of endocytosis for 120 min when compared to initial binding capacity. Receptor recycling was not impaired in hepatocytes from control animals. These results indicate that chronic ethanol feeding impairs the process of receptor-mediated endocytosis by the liver; the major cause of this impairment appears to be due to a decreased number of cell surface asialoglycoprotein receptors in the ethanol-fed animals, along with a decreased ability of these cells to internalize all of the surface-bound ligand.
Comparison of sirolimus-eluting vs. bare-metal stents for the treatment of infrapopliteal obstructions. (2006)

In this registry sirolimus-eluting stents were shown to be safe and effective in the treatment of focal infrapopliteal obstructions.
<i>KRE5</i>Gene Null Mutant Strains of<i>Candida albicans</i>Are Avirulent and Have Altered Cell Wall Composition and Hypha Formation Properties (2004)

The UDP-glucose:glycoprotein glucosyltransferase (UGGT) is an endoplasmic reticulum sensor for quality control of glycoprotein folding. Saccharomyces cerevisiae is the only eukaryotic organism so far described lacking UGGT-mediated transient reglucosylation of N-linked oligosaccharides. The only gene in S. cerevisiae with similarity to those encoding UGGTs is KRE5. S. cerevisiae KRE5 deletion strains show severely reduced levels of cell wall beta-1,6-glucan polymer, aberrant morphology, and extremely compromised growth or lethality, depending on the strain background. Deletion of both alleles of the Candida albicans KRE5 gene gives rise to viable cells that are larger than those of the wild type (WT), tend to aggregate, have enlarged vacuoles, and show major cell wall defects. C. albicans kre5/kre5 mutants have significantly reduced levels of beta-1,6-glucan and more chitin and beta-1,3-glucan and less mannoprotein than the WT. The remaining beta-1,6-glucan, about 20% of WT levels, exhibits a beta-1,6-endoglucanase digestion pattern, including a branch point-to-linear stretch ratio identical to that of WT strains, suggesting that Kre5p is not a beta-1,6-glucan synthase. C. albicans KRE5 is a functional homologue of S. cerevisiae KRE5; it partially complements both the growth defect and reduced cell wall beta-1,6-glucan content of S. cerevisiae kre5 viable mutants. C. albicans kre5/kre5 homozygous mutant strains are unable to form hyphae in several solid and liquid media, even in the presence of serum, a potent inducer of the dimorphic transition. Surprisingly the mutants do form hyphae in the presence of N-acetylglucosamine. Finally, C. albicans KRE5 homozygous mutant strains exhibit a 50% reduction in adhesion to human epithelial cells and are completely avirulent in a mouse model of systemic infection.
Correlation of Plasma Copeptin and Vasopressin Concentrations in Hypo-, Iso-, and Hyperosmolar States (2011)

Plasma vasopressin and copeptin correlate strongly over a wide range of osmolalities in healthy individuals. Therefore, the measurement of copeptin, which remains stable for several days, is a useful alternative to vasopressin measurements and will likely facilitate the differential diagnosis of disorders of water metabolism.
EnhancedTouchX (2019)

EnhancedTouchX, a bracelet-type interpersonal body area network device, not only detects but also quantifies interpersonal hand-to-hand touch interactions. Without any wired connection, it can identify the direction and gestures of a touch. The developed device can connect to an external device via Bluetooth Low Energy for monitoring and logging where, when, how long, who, and how the touch interactions occurred. These daily augmented touch interactions provided by such contextual information would offer a variety of applications to facilitate social interactions. Our experiment, conducted with several pairs of participants, demonstrates that the devices can identify the direction of a touch (from one initiating the touch (active touch) to the one being touched (passive touch)) with 95% accuracy. In addition, the devices are also capable of identifying four types of touch gestures with 85% accuracy using a simple threshold classifier.