gebhart/patrepeval huggingface dataset:
Nanocellulose-Assisted Formation of Porous Hematite Nanostructures (2014)

We report the formation of porous iron oxide (hematite) nanostructures via sol-gel transformations of molecular precursors in the confined space of self-organized nanocrystalline cellulose (NCC) used as a shape-persistent template. The obtained structures are highly porous α-Fe(2)O(3) (hematite) morphologies with a well-defined anisotropic porosity. The character of the porous nanostructure depends on the iron salt used as the precursor and the heat treatment. Moreover, a postsynthetic hydrothermal treatment of the NCC/iron salt composites strongly affects the crystal growth as well as the porous nanomorphology of the obtained hematite scaffolds. We demonstrate that the hydrothermal treatment alters the crystallization mechanism of the molecular iron precursors, which proceeds via the formation of anisotropic iron oxyhydroxide species. The nanocellulose templating technique established here enables the straightforward fabrication of a variety of mesoporous crystalline iron oxide scaffolds with defined porous structure and is particularly attractive for the processing of porous hematite films on different substrates.
[Identification of prognostic parameters for renal cell carcinoma by cDNA arrays and cell chips]. (1999)

We report here an example of how the combined application of cDNA and tumor array can lead to the identification of a novel prognostic marker within a very short time. A cDNA array analysis was performed on 5184 cDNA clones on a filter to screen for genes with differential expression between the renal cancer cell line CRL-1933 and normal kidney tissue to identify genes with relevance in RCC. There were 89 differentially expressed genes in the cancer cell line, one of them coding for vimentin, a cytoplasmic intermediate filament. To determine the in vivo prevalence and prognostic significance of vimentin expression, a renal cancer tissue micro array containing 532 RCC specimen was constructed and vimentin expression was determined by immunohistochemistry. Vimentin expression was frequently seen in clear-cell (51%) and papillary RCC (61%), but rarely in chromophobe RCC (4%) and oncocytomas (12%). These results obtained from minute arrayed tumor samples match with previous findings on vimentin expression in renal tumors. Furthermore, vimentin expression was significantly associated with poor patient prognosis (p < 0.007) independently of grade and stage. These results suggest that tissue microarray analysis provides a rapid and powerful method to determine the prevalence and prognostic significance of novel candidate genes discovered to be involved in cancer development with large-scale cDNA expression arrays. The tissue array can be adapted as a routine tool in research laboratories for analyses of large tumor series at the DNA, RNA or protein level. With such a tool, cancer researchers can study vast numbers of tumor samples in a short time and can generate a wealth of data on the application of tumor markers.
Combined acoustic and optical trapping (2011)

Combining several methods for contact free micro-manipulation of small particles such as cells or micro-organisms provides the advantages of each method in a single setup. Optical tweezers, which employ focused laser beams, offer very precise and selective handling of single particles. On the other hand, acoustic trapping with wavelengths of about 1 mm allows the simultaneous trapping of many, comparatively large particles. With conventional approaches it is difficult to fully employ the strengths of each method due to the different experimental requirements. Here we present the combined optical and acoustic trapping of motile micro-organisms in a microfluidic environment, utilizing optical macro-tweezers, which offer a large field of view and working distance of several millimeters and therefore match the typical range of acoustic trapping. We characterize the acoustic trapping forces with the help of optically trapped particles and present several applications of the combined optical and acoustic trapping, such as manipulation of large (75 μm) particles and active particle sorting.
Role of Bacterial Surface Structures on the Interaction of Klebsiella pneumoniae with Phagocytes (2013)

Phagocytosis is a key process of the immune system. The human pathogen Klebsiella pneumoniae is a well known example of a pathogen highly resistant to phagocytosis. A wealth of evidence demonstrates that the capsule polysaccharide (CPS) plays a crucial role in resistance to phagocytosis. The amoeba Dictyostelium discoideum shares with mammalian macrophages the ability to phagocytose and kill bacteria. The fact that K. pneumoniae is ubiquitous in nature and, therefore, should avoid predation by amoebae, poses the question whether K. pneumoniae employs similar means to counteract amoebae and mammalian phagocytes. Here we developed an assay to evaluate K. pneumoniae-D. discoideum interaction. The richness of the growth medium affected the threshold at which the cps mutant was permissive for Dictyostelium and only at lower nutrient concentrations the cps mutant was susceptible to predation by amoebae. Given the critical role of bacterial surface elements on host-pathogen interactions, we explored the possible contribution of the lipopolysaccharide (LPS) and outer membrane proteins (OMPs) to combat phagoyctosis by D. discoideum. We uncover that, in addition to the CPS, the LPS O-polysaccharide and the first core sugar participate in Klebsiella resistance to predation by D. discoideum. K. pneumoniae LPS lipid A decorations are also necessary to avoid predation by amoebae although PagP-dependent palmitoylation plays a more important role than the lipid A modification with aminoarabinose. Mutants lacking OMPs OmpA or OmpK36 were also permissive for D. discoideium growth. Except the LPS O-polysaccharide mutants, all mutants were more susceptible to phagocytosis by mouse alveolar macrophages. Finally, we found a correlation between virulence, using the pneumonia mouse model, and resistance to phagocytosis. Altogether, this work reveals novel K. pneumoniae determinants involved in resistance to phagocytosis and supports the notion that Dictyostelium amoebae might be useful as host model to measure K. pneumoniae virulence and not only phagocytosis.
SFC inside IEC 61499 (2006)

The international standard IEC 61499 defines an event-driven, distributed application based on function blocks. Such a block represents a kind of object with an internal behaviour. The blocks interact via input and output variables with other blocks or with their environment. This article describes an approach for the transformation of the sequential function chart (SFC) to IEC 61499 function blocks. The IEC 61499 function blocks are executed on a runtime, based on a distributed, object-oriented automation system, using objects interacting via the port concept.
ACAT inhibitor F-1394 prevents intimal hyperplasia induced by balloon injury in rabbits (2001)

Acyl-CoA:cholesterol acyltransferase (ACAT) is thought to contribute significantly to lipid deposition in macrophages, which subsequently leads to the initiation and progression of atherosclerosis. The aim of the present study was to examine the influence of hypercholesterolemia on arterial hyperplasia induced by endothelial denudation and the direct effect of ACAT inhibition on lesion formation. Rabbits were fed either a cholesterol diet or a regular diet for 4 weeks, and then the left common carotid arteries were denuded of endothelium. After the operation, all rabbits were kept on the regular diet for 2;-6 weeks. Two weeks after the denudation, the degree of intimal thickening and the number of proliferating cells (which were immunohistologically identified to be smooth muscle cells) were similar in hypercholesterolemic and normolipidemic rabbits. After that, both parameters progressively increased in hypercholesterolemic rabbits but declined in normolipidemic rabbits. Macrophages were apparent in the lesions only in hypercholesterolemic rabbits. Next, the effect of the ACAT inhibitor, (1S,2S)-2-[3-(2,2-dimethylpropyl)-3-nonylureido] cyclohexane-1-yl 3-[(4R)-N-(2,2,5,5-tetramethyl-1,3-dioxane-4-carbonyl)amino]propionate (F-1394), on neointimal formation in hypercholesterolemic rabbits was examined. Oral administration of F-1394 significantly reduced neointimal thickening and the extent of macrophages in lesions without affecting serum cholesterol levels. These results suggest that hypercholesterolemia causes macrophage-derived foam cell accumulation in lesions, and that the progression of lesions is accelerated by the presence of macrophages. Moreover, the study shows that F-1394 prevents neointimal formation even in the presence of hypercholesterolemia, indicating that F-1394 may be useful for treating restenosis after percutaneous translumenal coronary angioplasty in hyperlipidemic patients.
Solvent Extraction of Oil from Moringa (Moringa oleifera) (2004)

We report the extraction of seed kernel oil from moringa (Moringa oleifera) with hexane, petroleum ether and acetone as the first extraction medium. Hexane yielded maximum percent oil. After optimization of particle size (0.62 mm), extraction temperature (56.5oC) and residence time (7 h) maximum extraction of oil was 33.5%. This protocol provides improved opportunities for the medicinal use of moringa in addition to its popularity as a vegetable in south Asia.
Integration of catheter flow sensor onto tracheal intubation tube system (2013)

A MEMS flow sensor was integrated into the tracheal intubation tube system to avoid the misguided insertion of the tube into the esophagus. MEMS technology was used to fabricate a thermal flow sensor onto a flexible polyimide film, and then a heat shrinkable tube was used as packaging to mount it on the inside surface of the tube to produce a catheter flow sensor configuration. The catheter flow sensor was integrated into the inside of the slip joint by using an adapter produced using a molding process. The relationship between the sensor output and the flow rate was evaluated, and closely-matched sensor outputs for both the forward and backward flows were obtained. The tracheal tube in the developed system was inserted into the air passage of a rabbit, and the air flow passing through the tube was directly measured by the integrated catheter flow sensor in real-time. We believe that a doctor can easily evaluate whether the tube is inserted into the bronchi or the esophagus when using our system.
Non-consistent dual register files to reduce register pressure (2002)

The continuous grow on instruction level parallelism offered by microprocessors requires a large register file and a large number of ports to access it. This paper presents the non-consistent dual register file, an alternative implementation and management of the register file. Non-consistent dual register files support the bandwidth demands and the high register requirements, penalizing neither access time nor implementation cost. The proposal is evaluated for software pipelined loops and compared against a unified register file. Empirical results show improvements on performance and a noticeable reduction of the density of memory traffic due to a reduction of the spill code. The spill code can in general increase the minimum initiation interval and decrease loop performance. Additional improvements can be obtained when the operations are scheduled having in mind the register file organization proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Proceedings: Fourth Annual Workshop on Meteorological and Environmental Inputs to Aviation Systems (1980)

The proceedings of a workshop on meteorological and environmental inputs to aviation systems held at The University of Tennessee Space Institute, Tullahoma, Tennessee, March 25-27, 1980, are reported. The workshop was jointly sponsored by NASA, NOAA, and FAA and brought together many disciplines of the aviation communities in round table discussions. The major objectives of the workshop are to satisfy such needs of the sponsoring agencies as the expansion of our understanding and knowledge of the interaction of the atmosphere with aviation systems, the better definition and implementation of services to operators, and the collection and interpretation of data for establishing operational criteria relating the total meteorological inputs from the atmospheric sciences to the needs of aviation communities. The unique aspects of the workshop were the diversity of the participants and the achievement of communication across the interface of the boundaries between pilots, meteorologists, training personnel, accident investigators, traffic controllers, flight operation personnel from military, civil, general aviation, and commercial interests alike. Representatives were in attendance from government, airlines, private agencies, aircraft manufacturers, Department of Defense, industries, research institutes, and universities. Full-length papers from invited speakers addressed topics on icing, turbulence, wind and wind shear, ceilings and visibility, lightning, and atmospheric electricity. These papers are contained in the proceedings together with the committee chairmen's reports on the results and conclusions of their efforts on similar subjects.
Discovery of 4-Benzoyl-1-[(4-methoxy-1<i>H</i>- pyrrolo[2,3-<i>b</i>]pyridin-3-yl)oxoacetyl]-2- (<i>R</i>)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That Interferes with CD4-gp120 Interactions (2003)

Indole derivative 1 interferes with the interaction of the HIV surface protein gp120 with the host cell receptor CD4. The 4-fluoro derivative 2 exhibited markedly enhanced potency and was bioavailable in the rat, dog, and cynomolgus monkey when administered orally as a solution formulation. However, aqueous suspensions of 2 were poorly bioavailable, indicative of dissolution-limited absorption. The 7-azaindole derivative 3, BMS-378806, exhibited improved pharmaceutical properties while retaining the HIV-1 inhibitory profile of 2.
Automating the Application Data Placement in Hybrid Memory Systems (2017)

Multi-tiered memory systems, such as those based on Intel <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> Xeon Phi™ processors, are equipped with several memory tiers with different characteristics including, among others, capacity, access latency, bandwidth, energy consumption, and volatility. The proper distribution of the application data objects into the available memory layers is key to shorten the time- to-solution, but the way developers and end-users determine the most appropriate memory tier to place the application data objects has not been properly addressed to date. In this paper we present a novel methodology to build an extensible framework to automatically identify and place the application's most relevant memory objects into the Intel Xeon Phi fast on-package memory. Our proposal works on top of inproduction binaries by first exploring the application behavior and then substituting the dynamic memory allocations. This makes this proposal valuable even for end-users who do not have the possibility of modifying the application source code. We demonstrate the value of a framework based in our methodology for several relevant HPC applications using different allocation strategies to help end-users improve performance with minimal intervention. The results of our evaluation reveal that our proposal is able to identify the key objects to be promoted into fast on-package memory in order to optimize performance, leading to even surpassing hardware-based solutions.
Photodynamic Action Increases Leakage of the Mitochondrial Electron Transport Chain (1995)

Rat liver submitochondrial particles were treated with rose bengal or flavin mononucleotide and irradiated with visible or near UV light. In both cases, oxygen consumption is impaired after irradiation while O2-. production increases significantly. This suggests that exogenous or endogenous photosensitizers can induce more electron leakage in the mitochondrial respiratory chain. Photobiological implications in dermatology are discussed.
The Complete Nucleotide Sequence of Plum Pox Virus RNA (1989)

The complete nucleotide sequence of the RNA of an aphid non-transmissible plum pox virus (PPV-NAT) isolate has been determined from five overlapping cDNA clones. cDNA prepared by primer extension was used to determine the 5' terminus. The assembled RNA is 9741 nucleotides in length, excluding a 3' terminal poly(A) sequence. One large open reading frame starts at nucleotide positions 36 to 38 and is terminated with an UAG codon at positions 9522 to 9524. The putative start codon is located at positions 147 to 149. The encoded polyprotein has a predicted Mr of 353.8K. Comparison of cistrons from tobacco vein mottling virus and tobacco etch virus with those predicted for PPV-NAT indicated a similar genome organization. A highly conserved sequence of 12 nucleotides was found in the 5' non-coding region of these three potyviruses. The potential polyadenylation signal from yeast (UAUGU) was found in the 3' non-coding region of PPV-NAT and several other members of the potyvirus group.
Cluster analysis of amino acid indices for prediction of protein structure and function (1988)

The relationship among 222 published indices representing various physicochemical and biochemical properties of amino acid residues has been investigated by hierarchical cluster analysis. The clustering result is illustrated by the minimum spanning tree, which is conveniently divided into four regions: alpha and turn propensities, beta propensity, hydrophobicity and other physicochemical properties including, among others, bulkiness of amino acid residues. In addition, several subclasses of hydrophobicity scales have been identified: preference of inside and outside, accessible surface area, surrounding hydrophobicity and other mostly experimental scales including transfer free energy, partition coefficients, HPLC parameters and polarity. Representative amino acid indices are identified in each of these groups. The collection of amino acid indices is a useful resource for empirical analyses correlating sequence information with structural and functional properties of proteins. As an example, the indices that best reproduce the amino acid mutation data matrix are searched against this collection.
Determination of amines in indoor air from steam humidification (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleDetermination of amines in indoor air from steam humidificationSylvia A. Edgerton, Donald V. Kenny, and Darrell W. JosephCite this: Environ. Sci. Technol. 1989, 23, 4, 484–488Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/es00181a016https://doi.org/10.1021/es00181a016research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Effect of Castration on Benign Hypertrophy of the Prostate in Man (2016)

No AccessJournal of Urology1 Feb 2017The Effect of Castration on Benign Hypertrophy of the Prostate in Man1 Charles Huggins and Roland A. Stevens Charles HugginsCharles Huggins More articles by this author and Roland A. StevensRoland A. Stevens More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.10.075AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 197Issue 2SFebruary 2017Page: S66-S75 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.MetricsAuthor Information Charles Huggins More articles by this author Roland A. Stevens More articles by this author Expand All Advertisement PDF downloadLoading ...
Single Subject Pharmacological-MRI (phMRI) Study: Modulation of Brain Activity of Psoriatic Arthritis Pain by Cyclooxygenase-2 Inhibitor (2005)

We use fMRI to examine brain activity for pain elicited by palpating joints in a single patient suffering from psoriatic arthritis. Changes in these responses are documented when the patient ingested a single dose of a selective cyclooxygenase-2 inhibitor (COX-2i). We show that mechanical stimulation of the painful joints exhibited a cortical activity pattern similar to that reported for acute pain, with activity primarily localized to the thalamus, insular, primary and secondary somatosensory cortices and the mid anterior cingulum. COX-2i resulted in significant decreased in reported pain intensity and in brain activity after 1 hour of administration. The anterior insula and SII correlated with pain intensity, however no central activation site for the drug was detected. We demonstrate the similarity of the activation pattern for palpating painful joints to brain activity in normal subjects in response to thermal painful stimuli, by performing a spatial conjunction analysis between these maps, where overlap is observed in the insula, thalamus, secondary somatosensory cortex, and anterior cingulate. The results demonstrate that one can study effects of pharmacological manipulations in a single subject where the brain activity for a clinical condition is delineated and its modulation by COX-2i demonstrated. This approach may have diagnostic and prognostic utility.
Nonaneurysmal Subarachnoid Hemorrhage (2019)

Abstract: Spontaneous subarachnoid hemorrhage can arise from several possible sources, including cerebrovascular malformations, malignancy, or other disorders. Careful clinical examination as well as specialized radiological studies are essential to ensure correct diagnosis and develop a treatment plan. This chapter reviews the diagnostic workup and additional considerations in the management of spontaneous subarachnoid hemorrhage from a nonaneurysmal source. This form of subarachnoid hemorrhage is a distinct clinical entity with a generally more benign course. However, proper work-up and management are necessary both to ensure that a more serious form of subarachnoid hemorrhage does not exist and that the complications that can arise do not cause patient morbidity.