gebhart/patrepeval huggingface dataset:
Heterodimetal–Betaine Chemistry: Catalytic and Stoichiometric Coupling of Alkynyl Ligands under the Joint Influence of Zirconium and Boron Centers (1994)

Readily accessible from bis(propynyl)zirconocene, the organometallic betaines like 1 form by an intramolecular alkyne insertion and trapping reaction with tBuNC from an intermediate that has a hexadiyne ligand unsymmetrically coordinated to the Zr and B centers. This diyne complex is obtained in a rapid CC coupling reaction reaction between the starting material and B(C6F5)3.
Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation (2019)

Patients with late-stage Kellgren-Lawrence knee osteoarthritis received a single intra-articular injection of 1, 10, or 50 million bone marrow mesenchymal stromal cells (BM-MSCs) in a phase I/IIa trial to assess safety and efficacy using a broad toolset of analytical methods. Besides safety, outcomes included patient-reported outcome measures (PROMs): Knee Injury and Osteoarthritis Outcome Score (KOOS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); contrast-enhanced magnetic resonance imaging (MRI) for cartilage morphology (Whole Organ MRI Scores [WORMS]), collagen content (T2 scores), and synovitis; and inflammation and cartilage turnover biomarkers, all over 12 months. BM-MSCs were characterized by a panel of anti-inflammatory markers to predict clinical efficacy. There were no serious adverse events, although four patients had minor, transient adverse events. There were significant overall improvements in KOOS pain, symptoms, quality of life, and WOMAC stiffness relative to baseline; the 50 million dose achieved clinically relevant improvements across most PROMs. WORMS and T2 scores did not change relative to baseline. However, cartilage catabolic biomarkers and MRI synovitis were significantly lower at higher doses. Pro-inflammatory monocytes/macrophages and interleukin 12 levels decreased in the synovial fluid after MSC injection. The panel of BM-MSC anti-inflammatory markers was strongly predictive of PROMs over 12 months. Autologous BM-MSCs are safe and result in significant improvements in PROMs at 12 months. Our analytical tools provide important insights into BM-MSC dosing and BM-MSC reduction of synovial inflammation and cartilage degradation and provide a highly predictive donor selection criterion that will be critical in translating MSC therapy for osteoarthritis. Stem Cells Translational Medicine 2019;8:746&757.
A simplified approach to electrocardiography (1986)

This practical text-workbook provides an introduction to electrocardiographic interpretation, using clear, high quality tracings, summary tables, charts and diagrams. Reviews the fundamentals of electrocardiogram interpretation and acquaints the reader with common electrocardiographic tracings. Appropriate pathophysiology is included to enhance understanding of electrocardiographic abnormalities.
Mechanical Purification of Single-Walled Carbon Nanotube Bundles from Catalytic Particles (2002)

Ferromagnetic particles used for the catalytic growth of single-walled carbon nanotubes (SWNTs), which are embedded in a graphitic shell, represent a major obstacle in studying the bulk material. We have explored a purification method that is based on a mixing of the SWNT suspension with inorganic nanoparticles in an ultrasonic bath, which causes ferromagnetic particles to be mechanically removed from their graphitic shells. By trapping these magnetic particles with permanent magnetic poles and with a subsequent chemical treatment, a high purity SWNT material was obtained.
<i>p</i>-type delta-doped layers in silicon: Structural and electronic properties (1990)

We report on the properties of p-type delta-doped layers prepared in molecular beam epitaxy-Si by growth interruption and evaporation of elemental B. Secondary-ion mass spectrometry measurements at several primary ion energies have been used to show that the full width at half maximum is ∼2 nm. Hall measurements confirm that the layers are completely activated at 300 K with a mobility of 30±5 cm2/V s for a carrier density of (9±2)×1012 cm−2. At temperatures below 70 K nonmetallic behavior is observed which we have attributed to conduction between impurity states. It is concluded that the critical acceptor separation for the Mott metal-insulator transition in this system is significantly less than the value found in uniformly doped Si:B.
Comparison of Phased-Array 3.0-T and Endorectal 1.5-T Magnetic Resonance Imaging in the Evaluation of Local Staging Accuracy for Prostate Cancer (2007)

The 3.0-T phased-array MRI is equivalent to the 1.5-T endorectal MRI in evaluating local staging accuracy for prostate cancer without significant loss of imaging quality.
Fault detection and isolation in robotic manipulator via hybrid neural networks (2008)

Fault diagnosis systems are important for industrial robots, especially those operated in remote and hazardous environment. Faults in robotic manipulator can cause economic and serious damages. So the Robots need the ability to independently as well as effectively detect and tolerate internal failures in order to continue performing their tasks without the need for immediate human intervention. This saves time and cost involved in repairing the robot. This type of autonomous fault tolerance is also useful for industrial robots in that it decreases down-time by tolerating failures, identifies faulty components or subsystems to speed up the repair process, and prevents the robot from damaging the products being manufactured. So an attempt is made to develop a robust fault detection system to identify and isolate the faults in robot manipulator. In this paper, two artificial neural networks are employed to identify and isolate the faults. A learning architecture, approximation of dynamic behavior of robot manipulator, is used to generate the residual vector, by comparing with actual measured values. First, A multi layer perceptron feed forward network, whose structure is characterized by layered graph, trained with back propagation algorithm is applied to reproduce the dynamic behavior, then counter propagation network which learns a near optimal look uptable approximation to the mapping being approximated. The counter propagation network has the ability to compress a huge amount of data in a few weights and parameters. Simulations employing a SCORBOT ER 5u plus five links robotic manipulator are showed demonstrating that the system can detect and isolate correctly faults that occur in non-trained trajectories. The main contribution of this work is the first application of fault detection and isolation to robot manipulator with non-additive fault.
On patrol (2001)

article Share on On patrol: resource allocation, proofs of work, and consequences Author: David Molnar Harvard Univ., Cambridge, MA Harvard Univ., Cambridge, MAView Profile Authors Info & Claims XRDS: Crossroads, The ACM Magazine for StudentsVolume 7Issue 3March 2001 pp 28–31https://doi.org/10.1145/367884.367899Online:15 March 2001Publication History 0citation122DownloadsMetricsTotal Citations0Total Downloads122Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Epitopes of Herpes Simplex Virus Type 1 Glycoprotein B that Bind Type-Common Neutralizing Antibodies Elicit Type-Specific Antibody-Dependent Cellular Cytotoxicity (1992)

A panel of 45 well-characterized monoclonal antibodies (MAbs) reactive to glycoprotein B (gB) of herpes simplex virus (HSV) type 1 was tested by ELISA and in antiviral functional assays (that included virus neutralization, antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent complement-mediated lysis), using type 1 or 2 virus strains. All MAbs were ELISA-reactive. Eleven of the MAbs mediated neutralization and 9 mediated ADCC. All of the ADCC epitopes were contained within the amino-terminal half of the extracellular portion of gB. The ADCC reactions were strictly type 1-specific, whereas 9 of 11 neutralizing MAbs exhibited type-common activity. There was some association between the ADCC and neutralization activities, since of 12 MAbs with functional activity, 8 were positive in both assays. These results suggest that differences in the presentation of gB, and perhaps HSV-1 gB versus HSV-2 gB, on free virus and virus-infected cells determine epitope availability.
Improve Data Quality by Processing Null Values and Semantic Dependencies (2016)

Today, the quantity of data continues to increase, furthermore, the data are heterogeneous, from multiple sources (structured, semi-structured and unstructured) and with different levels of quality. Therefore, it is very likely to manipulate data without knowledge about their structures and their semantics. In fact, the meta-data may be insufficient or totally absent. Data Anomalies may be due to the poverty of their semantic descriptions, or even the absence of their description. In this paper, we propose an approach to better understand the semantics and the structure of the data. Our approach helps to correct automatically the intra-column anomalies and the inter-col- umns ones. We aim to improve the quality of data by processing the null values and the semantic dependencies between columns.
A new class of amino acid based sweeteners (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new class of amino acid based sweetenersWilliam D. Fuller, Murray Goodman, and Michael S. VerlanderCite this: J. Am. Chem. Soc. 1985, 107, 20, 5821–5822Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/ja00306a051https://doi.org/10.1021/ja00306a051research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Platform for Building New Human-Computer Interface Systems that Support Online Automatic Recognition of Audio-Gestural Commands (2016)

We introduce a new framework to build human-computer interfaces that provide online automatic audio-gestural command recognition. The overall system allows the construction of a multimodal interface that recognizes user input expressed naturally as audio commands and manual gestures, captured by sensors such as Kinect. It includes a component for acquiring multimodal user data which is used as input to a module responsible for training audio-gestural models. These models are employed by the automatic recognition component, which supports online recognition of audio-visual modalities. The overall framework is exemplified by a working system use case. This demonstrates the potential of the overall software platform, which can be employed to build other new human-computer interaction systems. Moreover, users may populate libraries of models and/or data, that can be shared in the network. In this way users may reuse or extend existing systems.
Securing IEDs against cyber threats in critical substation automation and industrial control systems (2017)

The operational technologies that support critical infrastructure industries, such as manufacturing, transportation, and energy, depend heavily on information systems for their monitoring and control. Industrial control system (ICS) is a general term that is used to represent systems such as supervisory control and data acquisition (SCADA) systems, distributed control systems (DCS), and other control system configurations, such as programmable logic controllers (PLC). Substation Automation System (SAS) controls the power system via instrumentation and control devices.
Plasmonic photodetectors based on asymmetric nanogap electrodes (2016)

Abstract Hot electrons excited by plasmon resonance in nanostructure can be employed to enhance the properties of photodetectors, even when the photon energy is lower than the bandgap of the semiconductor. However, current research has seldom considered how to realize the efficient collection of hot electrons, which restricts the responsivity of the device. In this paper, a type of plasmonic photodetector based on asymmetric nanogap electrodes is proposed. Owing to this structure, the device achieves responsivities as high as 0.45 and 0.25 mA/W for wavelengths of 1310 and 1550 nm, respectively. These insights can aid the realization of efficient plasmon-enhanced photodetectors for infrared detection.
Heterocycles in organic synthesis. Part 19. Thermolysis of pyridinium N-acylimines : a new preparation of isocyanates (1979)

2,4,6-Triphenylpyrylium perchlorate converts hydrazides into the 1-amidopyridinium perchlorates (25) which are easily deprotonated to the free pyridinium 1-acylimines (8). These are alternatively prepared by acylation of the 1-amino-2,4,6-triphenylpyridinium cation. The 1-acylimines undergo smooth thermolysis to 2,4,6-triphenylpyridine and the corresponding isocyanates, constituting a practical synthetic method for the latter. 1-Thioamidosalts (28) were prepared: the corresponding 1-thioacylimines are unstable and decompose to the corresponding cyanides and sulphur.
Computing in Civil Engineering: Proceedings of the Third Congress Held in Conjunction with A. E. C. Systems '96, Anaheim, California, June 17-19, 1996 (1996)

This book contains papers presented at the Sixth Conference on Computing in Civil Engineering held on September 11-13, 1989 in Atlanta, GA. This series, initiated in 1978, provides a continuing forum for the advancement of intelligent computer use in the profession. In addition to introductory topics, cross-pollination of ideas and techniques from related professions and organizations will be of benefit to even the most experienced computer users. The conference brings together diverse groups within the profession and those affiliated with it to share knowledge, experience and techniques. The objective is to disseminate current and projected developments in both software and hardware and to educate users in the ways in which computers can be applied to practice, administration and education. The book includes papers from a Symposium on Expert Systems in Civil Engineering, as well as topics describing computer use in construction management, geographic information systems and computer applications in large and small engineering firms as well as in government and education.
A low temperature reaction sequence for methane conversion (1991)

Surface carbonaceous intermediates produced from methane are shown to produce small alkanes upon hydrogenation below 400 K.
Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes. (1983)

The chronic tissue damage associated with long-term diabetes mellitus may arise in part from in situ immune complex formation by accumulated immunoglobulins and/or antigens bound to long-lived structural proteins that have undergone excessive nonenzymatic glycosylation. In this report, we have tested this hypothesis using nonenzymatically glycosylated collagen. Binding of both albumin and IgG averaged four times the amount bound to unmodified collagen. Both albumin and IgG (anti-BSA) bound to nonenzymatically glycosylated collagen retained their ability to form immune complexes in situ with free antibody and antigen.
Decrease and Structural Modifications of Phosphatidylethanolamine Plasmalogen in the Brain with Alzheimer Disease (1999)

Several lipid modifications, some of which were attributed to oxidative stress, have been reported in the brains of patients with Alzheimer disease (AD). To evaluate this possibility, all phospholipids and their ether subclasses from the frontal cortex, hippocampus, and the white matter of AD brain were analyzed by high performance liquid chromatography and gas chromatography. The total phospholipid in the frontal cortex and hippocampus decreased on a DNA basis by about 20% and this change was essentially explained by a selective decrease in phosphatidylethanolamine and phosphatidylcholine. The lower content of phosphatidylethanolamine was due to a specific decrease in the plasmalogen subclass. Phosphatidylethanolamine plasmalogen was also the only lipid exhibiting major structural modifications: a significant decrease in polyunsaturated fatty acids and oleic acid as well as a shift of the aldehyde pattern from 18:1 to 18:0. The only modification observed in the other phospholipids was a decrease in oleic acid in diacyl-phosphatidylethanolamine and diacyl-phosphatidylcholine. None of these changes were observed in the white matter. Both the vinyl ether bond of phosphatidylethanolamine plasmalogen and polyunsaturated fatty acids are major targets in oxidative stress; thus, these specific lipid modifications strongly support the involvement of free radicals in the pathogenesis of AD.
Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory (2017)

Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca<sup>2+</sup>-dependent protease that exerts its effects through the proteolytic cleavage of target proteins. Neuron-specific conditional deletions of calpain 1 and 2 impair long-term potentiation in the hippocampus and spatial learning. Moreover, recent studies have suggested distinct roles of calpain 1 and 2 in synaptic plasticity. However, the role of hippocampal calpain in memory processes, especially memory consolidation, reconsolidation, and extinction, is still unclear. In the current study, we demonstrated the critical roles of hippocampal calpain in the consolidation, reconsolidation, and extinction of contextual fear memory in mice. We examined the effects of pharmacological inhibition of calpain in the hippocampus on these memory processes, using the N-Acetyl-Leu-Leu-norleucinal (ALLN; calpain 1 and 2 inhibitor). Microinfusion of ALLN into the dorsal hippocampus impaired long-term memory (24 h memory) without affecting short-term memory (2 h memory). Similarly, this pharmacological blockade of calpain in the dorsal hippocampus also disrupted reactivated memory but did not affect memory extinction. Importantly, the systemic administration of ALLN inhibited the induction of c-fos in the hippocampus, which is observed when memory is consolidated. Our observations showed that hippocampal calpain is required for the consolidation and reconsolidation of contextual fear memory. Further, the results suggested that calpain contributes to the regulation of new gene expression that is necessary for these memory processes as a regulator of Ca<sup>2+</sup>-signal transduction pathway.
Standing-wave EO phase modulatorusing non-periodic domain inversion for large modulation index (2000)

A deep microwave EO phase modulator using a standing-wave electrode structure together with non-periodic domain inversion is presented. The calculation and experimental results show that the maximum modulation index obtained by this modulator is 30% higher than the best result obtained for a travelling-wave EO phase modulator with periodic domain inversion.
Activation of the Inflammasome and Enhanced Migration of Microparticle-Stimulated Dendritic Cells to the Draining Lymph Node (2012)

Porous silicon microparticles presenting pathogen-associated molecular patterns mimic pathogens, enhancing internalization of the microparticles and activation of antigen presenting dendritic cells. We demonstrate abundant uptake of microparticles bound by the TLR-4 ligands LPS and MPL by murine bone marrow-derived dendritic cells (BMDC). Labeled microparticles induce concentration-dependent production of IL-1β, with inhibition by the caspase inhibitor Z-VAD-FMK supporting activation of the NLRP3-dependent inflammasome. Inoculation of BALB/c mice with ligand-bound microparticles induces a significant increase in circulating levels of IL-1β, TNF-α, and IL-6. Stimulation of BMDC with ligand-bound microparticles increases surface expression of costimulatory and MHC molecules, and enhances migration of BMDC to the draining lymph node. LPS-microparticles stimulate in vivo C57BL/6 BMDC and OT-1 transgenic T cell interactions in the presence of OVA SIINFEKL peptide in lymph nodes, with intact nodes imaged using two-photon microscopy. Formation of in vivo and in vitro immunological synapses between BMDC, loaded with OVA peptide and LPS-microparticles, and OT-1 T cells are presented, as well as elevated intracellular interferon gamma levels in CD8(+) T cells stimulated by BMDC carrying peptide-loaded microparticles. In short, ligand-bound microparticles enhance (1) phagocytosis of microparticles; (2) BMDC inflammasome activation and upregulation of costimulatory and MHC molecules; (3) cellular migration of BMDC to lymphatic tissue; and (4) cellular interactions leading to T cell activation in the presence of antigen.
Anthracene−Maleimide-Based Diels−Alder “Click Chemistry” as a Novel Route to Graft Copolymers (2006)

Using the Diels−Alder (DA) “click chemistry” strategy between anthracene and maleimide functional groups, two series of well-defined polystyrene-g-poly(ethylene glycol) (PS-g-PEG) and polystyrene-g-poly(methyl methacrylate) (PS-g-PMMA) copolymers were successfully prepared. The whole process was divided into two stages: (i) preparation of anthracene and maleimide functional polymers and (ii) the use of Diels−Alder reaction of these groups. First, random copolymers of styrene (S) and chloromethylstyrene (CMS) with various CMS contents were prepared by the nitroxide-mediated radical polymerization (NMP) process. Then, the choromethyl groups were converted to anthryl groups via the etherifaction with 9-anthracenemethanol. The other component of the click reaction, namely protected maleimide functional polymers, were prepared independently by the modification of commercially available poly(ethylene glycol) (PEG) and poly(methyl methacrylate) (PMMA) obtained by atom transfer radical polymerization (ATRP) using the corresponding functional initiator. Then, in the final stage PEG and PMMA prepolymers were deprotected by retro-Diels−Alder in situ reaction by heating at 110 °C in toluene. The recovered maleimide groups and added anthryl functional polystyrene undergo Diels−Alder reaction to form the respective (PS-g-PEG) and (PS-g-PMMA) copolymers. The graft copolymers and the intermediates were characterized in detail by using 1H NMR, GPC, UV, fluorescence, DSC, and AFM measurements.