gebhart/patrepeval huggingface dataset:
4-(6-Hydroxy-2-naphthyl)-1,3-bezendiol: A Potent, New Tyrosinase Inhibitor (2007)

Tyrosinase is a key enzyme for melanin biosynthesis and known to be sensitive to ultraviolet light in the presence of oxygen. Therefore, finding effective tyrosinase inhibitors, either from synthetic or natural sources, can be beneficial in the treatment of melanin-related disorders. We synthesized 4-(6-hydroxy-2-naphthyl)-1,3-bezendiol (HNB), a new family of hydroxyl substituted phenyl naphthalenes, as the isosteres of oxyresveratrol. This study investigated inhibitory effects of HNB on tyrosinase activity. HNB inhibited mushroom tyrosinase with an IC(50) value of 0.07 microM, which is more potent than the anti-tyrosinase activity of kojic acid (IC(50)=38.24), a well-known tyrosinase inhibitor. The kinetic analysis of tyrosinase inhibition revealed that HNB is a competitive inhibitor (K(i) 4.78 x 10(-9) M at 0.125 microM and K(i) 6.21 x 10(-9) M at 0.25 microM). We further found that HNB also inhibited melanin production in B16F10 melanoma cells (B16 cells). In addition to tyrosinase inhibiting activity, melanin biosynthesis was inhibited by HNB in the B16F10 cells. These data strongly suggest that HNB can suppress the production of melanin via the modulation of tyrosinase activity.
Identification of Pneumocystis carinii chromosomes and mapping of five genes (1990)

Pulsed field gel electrophoresis was used to identify the chromosome-size DNA of Pneumocystis carinii, a major pathogen of immunocompromised patients. Thirteen chromosomes of rodent Pneumocystis carinii, ranging in size from 300 to 700 kilobases (kb), were identified. The minimum genome size for P. carinii, estimated on the basis of the sizes of chromosomes, is 7,000 kb. Genetic heterogeneity among different P. carinii isolates was documented by demonstration of chromosomal size variability. By hybridization studies, the genes for topoisomerase I, dihydrofolate reductase, rRNA, actin, and thymidylate synthase were mapped to single chromosomes of approximately 650, 590, 550, 460, and 350 kb, respectively. Hybridization studies further confirmed the genetic heterogeneity of P. carinii.
Beach Sands along the California Coast Are Diffuse Sources of Fecal Bacteria to Coastal Waters (2007)

Fecal indicator bacteria (FIB) are nearly ubiquitous in California (CA) beach sands. Sands were collected from 55 beaches along the CA coast. Ninety-one percent of the beaches had detectable enterococci (ENT) while 62% had detectable E. coli (EC) in their sands. The presence of a putative bacterial source (such as a river), the degree of wave shelter, and surrounding land use explained a significant (p < 0.05) fraction of the variation in both ENT and EC densities between beaches. Sand characteristics including moisture content, organic carbon, and percentfines, significantly (p < 0.05) influenced only EC densities in beach sand. We assayed 34 of 163 sand samples for salmonellae, but did not detect this bacterial pathogen. The potential for FIB to be transported from the sand to sea was investigated at a single wave-sheltered beach with high densities of ENT in beach sand: Lovers Point, CA (LP). We collected samples of exposed and submerged sands as well as water over a 24 h period in order to compare the disappearance or appearance of ENT in sand and the water column. Exposed sands had significantly higher densities of ENT than submerged sands with the highest densities located near the high tide line. Water column ENT densities began low, increased sharply during the first flood tide and slowly decreased over the remainder of the study. During the first flood tide, the number of ENT that entered the water column was nearly equivalent to the number of ENT lost from exposed sands when they were submerged by seawater. The decrease in nearshore ENT concentrations after the initial influx can be explained by ENT die-off and dilution with clean ocean water. While some ENT in the water and sand at LP might be of human origin because they were positive for the esp gene, others lacked the esp gene and were therefore equivocal with respect to their origin. Follow-up sampling at LP revealed the presence of the human specific Bacteroides marker in water and sand.
Cancer-Associated Glycoforms of Gelatinase B Exhibit a Decreased Level of Binding to Galectin-3 (2006)

Gelatinase B (MMP-9) and galectin-3 are widely known to participate in tumor cell invasion and metastasis. Glycans derived from MMP-9 expressed in MCF-7 breast cancer and THP-1 myeloid leukemia cells were compared with those from MMP-9 expressed in natural neutrophils. The many O-linked glycans of neutrophil gelatinase B presented a cluster of mainly galactosylated core II structures, 46% of which were ligands for galectin-3; 11% contained two to three N-acetyllactosamine repeating units that are high-affinity ligands for the lectin. The glycan epitopes thus provide MMP-9 with both high-affinity and (presumably) high-avidity interactions with galectin-3. In contrast, the O-glycans released from MMP-9 expressed in MCF-7 and THP-1 cells were predominantly sialylated core I structures. Only 10% of MCF-7 and THP-1 gelatinase B O-glycans were ligands for galectin-3 and contained only a maximum single N-acetyllactosamine repeat. Consistent with the glycan analysis, surface plasmon resonance binding assays indicated that the cancer-associated glycoforms of MMP-9 bound galectin-3 with an affinity and avidity significantly reduced compared with those of the natural neutrophil MMP-9. Galectin-3 exists as a multimer that also binds laminin, providing a means of localizing neutrophil MMP-9 in the extracellular matrix (ECM). The analytical data presented here suggest that MMP-9 glycoforms secreted by tumor cells are unlikely to be tethered at the site of secretion, thus promoting more extensive cleavage of the ECM and providing a rationale for the contribution that gelatinase B makes to cancer cell metastasis.
Regulation of low density lipoprotein receptor synthesis in cultured luteinized human granulosa cells by human chorionic gonadotropin and 8-bromo-cyclic AMP. (1985)

We investigated the regulation of synthesis of low density lipoprotein (LDL) receptor in cultured luteinized human granulosa cells using a monoclonal antibody recognizing the human LDL receptor (IgG-C7). Cells cultured under serum-free conditions were treated with human chorionic gonadotropin (hCG) or 8-bromo-cAMP alone or in combination with aminoglutethimide (to block conversion of cholesterol to steroid hormones) and 5-cholesten-3 beta, 25-diol (25-hydroxycholesterol, a potent suppressor of LDL receptor expression in human fibroblasts) and pulse-labeled with [35S]methionine. A labeled protein immunoisolated with IgG-C7 was identified as the mature LDL receptor in 7.5% sodium dodecyl sulfate-polyacrylamide gels on the basis of an apparent molecular mass of 160 kDa, absence of the protein from immunoisolates prepared with a monoclonal antibody against an irrelevant antigen, and an apparent decrease in molecular weight of the mature receptor upon treatment with neuraminidase or electrophoresis under nonreducing conditions. hCG and 8-bromo-cAMP consistently increased the incorporation of radioactivity into the mature LDL receptor by 2-6-fold. The effect of hCG on LDL receptor synthesis was observed with as little as 10 mIU of hCG/ml and was apparent within 2 h of addition of the hormone. A combination of 25-hydroxycholesterol and aminoglutethimide resulted in a 60% suppression of label incorporation into mature LDL receptor compared to untreated cells. This would suggest some regulation of LDL receptor synthesis by negative feedback of sterol. However, both hCG and 8-bromo-cAMP increased label incorporation into the LDL receptor in the face of these agents. We conclude that in human granulosa cells, hCG, through the intermediacy of cAMP, rapidly increases LDL receptor synthesis by a mechanism which is, at least in part, independent of alterations in cellular cholesterol balance.
On the Design of the Contraction Cone for a Wind Tunnel (1943)

In desicning the contraction cone for a wind tunnel, the usual design condition is that the velocity at the end of the cone must befairly uniform. However, if the curvature of the wall along the flow direction is too large at certain points, local velocities at these points may exceed the uniform velocity at the end of the contraction cone. There are then regions of adverse pressure gradient and the boundary layer may separate from the wall. Furthermore, if the velocity at the end of the contraction cone is very high, say about 0.9 that of the sound, an additional factor enters — namely, the danger of compressibility shock. This danger can be avoided by keeping the velocity of flow below that of sound in the whole field of flow. In the particular case of a contraction cone, the highest velocity is reached at the wall of the cone. Therefore, if the velocity at the wall is made to increase monotonically † from the beginning of the cone to the end of cone the velocity in the cone will be always less than that of sound, provided that the velocity at the end of the contraction cone is less than the velocity of sound. The pressure along the wall will then be decreasing monotonically. Hence, the danger of boundary layer separation is also avoided.
Synthesis and characterization of a biodegradable elastomer featuring a dual crosslinking mechanism (2010)

The need for advanced materials in emerging technologies such as tissue engineering has prompted increased research to produce novel biodegradable polymers elastic in nature and mechanically compliant with the host tissue. We have developed a soft biodegradable elastomeric platform biomaterial created from citric acid, maleic anhydride, and 1,8-octanediol, poly(octamethylene maleate (anhydride) citrate) (POMaC), which is able to closely mimic the mechanical properties of a wide range of soft biological tissues. POMaC features a dual crosslinking mechanism, which allows for the option of the crosslinking POMaC using UV irradiation and/or polycondensation to fit the needs of the intended application. The material properties, degradation profiles, and functionalities of POMaC thermoset networks can all be tuned through the monomer ratios and the dual crosslinking mechanism. POMaC polymers displayed an initial modulus between 0.03 and 1.54 MPa, and elongation at break between 48% and 534% strain. In vitro and in vivo evaluation using cell culture and subcutaneous implantation, respectively, confirmed cell and tissue biocompatibility. POMaC biodegradable polymers can also be combined with MEMS technology to fabricate soft and elastic 3D microchanneled scaffolds for tissue engineering applications. The introduction of POMaC will expand the choices of available biodegradable polymeric elastomers. The dual crosslinking mechanism for biodegradable elastomer design should contribute to biomaterials science.
Wolfram Syndrome: Diagnosis, Management, and Treatment (2016)

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes mellitus, diabetes insipidus, optic nerve atrophy, hearing loss, and neurodegeneration. Although there are currently no effective treatments that can delay or reverse the progression of Wolfram syndrome, the use of careful clinical monitoring and supportive care can help relieve the suffering of patients and improve their quality of life. The prognosis of this syndrome is currently poor, and many patients die prematurely with severe neurological disabilities, raising the urgency for developing novel treatments for Wolfram syndrome. In this article, we describe natural history and etiology, provide recommendations for diagnosis and clinical management, and introduce new treatments for Wolfram syndrome.
Nested Kirkpatrick–Baez (Montel) optics for hard X-rays (2015)

A comprehensive description and ray-tracing simulations are presented for symmetric nested Kirkpatrick–Baez (KB) mirrors, commonly used at synchrotrons and in commercial X-ray sources. This paper introduces an analytical procedure for determining the proper orientation between the two surfaces composing the nested KB optics. This procedure has been used to design and simulate collimating optics for a hard-X-ray inverse Compton scattering source. The resulting optical device is composed of two 12 cm-long parabolic surfaces coated with a laterally graded multilayer and is capable of collimating a 12 keV beam with a divergence of 5 mrad (FWHM) by a factor of ∼250. A description of the ray-tracing software that was developed to simulate the graded multilayer mirrors is included.
Local histogram correction of MRI spatially dependent image pixel intensity nonuniformity (1996)

We describe a computationally straightforward post-hoc statistical method of correcting spatially dependent image pixel intensity nonuniformity based on differences in local tissue intensity distributions. Pixel intensity domains for the various tissues of the composite image are identified and compared to the distributions of local samples. The nonuniformity correction is calculated as the difference of the local sample median from the composite sample median for the tissue class most represented by the sample. The median was chosen to reduce the effecters on determining the sample statistic and to allow a sample size small enough to accurately estimate the spatial variance of the image intensity nonuniformity. The method was designed for application to two-dimensional images. Simulations were used to estimate optimal conditions of local histogram kernel size and to test the accuracy of the method under known spatially dependent nonuniformities. The method was also applied to correct a phantom image and cerebral MRIs from 15 healthy subjects. Results show that the method accurately models simulated spatially dependent image intensity differences. Further analysis of clinical MR data showed that the variance of pixel intensities within the cerebral MRI slices and the variance of slice volumes within individuals were significantly reduced after nonuniformity correction. Improved brain-cerebrospinal fluid segmentation was also obtained. The method significantly reduced the variance of slice volumes within individuals, whether it was applied to the native images or images edited to remove nonbrain tissues. This statistical method was well behaved under the assumptions and the images tested. The general utility of the method was not determined, but conditions for testing the method under a variety of imaging sequences is discussed. We believe that this algorithm can serve as a method for improving MR image segmentation for clinical and research applications.
SNIPER: Efficient Multi-Scale Training (2018)

We present SNIPER, an algorithm for performing efficient multi-scale training in instance level visual recognition tasks. Instead of processing every pixel in an image pyramid, SNIPER processes context regions around ground-truth instances (referred to as chips) at the appropriate scale. For background sampling, these context-regions are generated using proposals extracted from a region proposal network trained with a short learning schedule. Hence, the number of chips generated per image during training adaptively changes based on the scene complexity. SNIPER only processes 30% more pixels compared to the commonly used single scale training at 800x1333 pixels on the COCO dataset. But, it also observes samples from extreme resolutions of the image pyramid, like 1400x2000 pixels. As SNIPER operates on resampled low resolution chips (512x512 pixels), it can have a batch size as large as 20 on a single GPU even with a ResNet-101 backbone. Therefore it can benefit from batch-normalization during training without the need for synchronizing batch-normalization statistics across GPUs. SNIPER brings training of instance level recognition tasks like object detection closer to the protocol for image classification and suggests that the commonly accepted guideline that it is important to train on high resolution images for instance level visual recognition tasks might not be correct. Our implementation based on Faster-RCNN with a ResNet-101 backbone obtains an mAP of 47.6% on the COCO dataset for bounding box detection and can process 5 images per second during inference with a single GPU. Code is available at https://github.com/MahyarNajibi/SNIPER/.
Radio propagation measurements at 850 MHz, 1.7 GHz and 4 GHz inside two dissimilar office buildings (1990)

Time delay spread and signal level measurements were made in two dissimilar office buildings at 850 MHz, 1.7 GHz and 4.0 GHz. The RMS time delay spread did not deteriorate with increasing frequency in these buildings. Its maximum value at the three frequencies did not exceed 270 ns at the larger building and 100 ns at the smaller building. Attenuation was nearly the same at the three frequencies, but decreased slightly with increasing frequency, within the limits of the experiment's accuracy.
Localization of a novel X-linked congenital stationary night blindness locus: close linkage to the RP3 type retinitis pigmentosa gene region (1995)

X-linked congenital stationary night blindness (CSNBX) is a non-progressive retinal disorder characterized by decreased visual acuity and loss of night vision. CSNBX is clinically heterogeneous with respect to the involvement of retinal rods and/or cones in the disease. In this study, we localize a new locus for CSNBX to Xp21.1, thus providing evidence that CSNBX is also genetically heterogeneous. A clear correlation between different genotypes and phenotypes cannot be found yet. The new CSNBX gene described here is closely linked to the X-linked retinitis pigmentosa type 3 gene region, which supports the hypothesis that there may be a functional relationship between congenital stationary night blindness and retinitis pigmentosa.
THE MECHANISM OF BACTERIAL FRAGILITY PRODUCED BY 5-FLUOROURACIL: THE ACCUMULATION OF CELL WALL PRECURSORS (1960)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Bonded Repair of Metal Structures Using Composites (2001)

Abstract Composite bonded repair technology is based on the use of advanced composite repairs or reinforcements that are adhesively bonded to a damaged structure. This article discusses the key steps that are normally encountered in the design, certification, and application of an adhesively bonded repair. Some examples of successful repairs to military aircraft are also discussed.
Profiling Temperature, Pressure, and Aerosol Properties Using a High Spectral Resolution Lidar Employing Atomic Blocking Filters (1993)

A two-channel ground-based high spectra resolution Rayleigh-Mie lidar (553.7 nm) and its operation is described. Inversion of data collected with this unique lidar system yields vertical profiles of atmospheric parameters including temperature, potential temperature, pressure and density, as well as aerosol parameters including backscatter ratio, extinction ratio, aerosol volume extinction cross section, and backscatter phase function. The results of the lidar temperature profiles (within 10 K) are compared with those measured by a nearby balloonsonde. Although present accuracies are not acceptable for routine measurements, the concept has been demonstrated. Use of a more stable filter will significantly improve the accuracy of the temperature measurements. This technique makes accessible a fairly complete set of simultaneous measurements of thermodynamic and aerosol properties of the atmosphere.
Partially coupled electro-thermal analysis for accurate prediction of switching devices (2002)

Power hybrid assemblies including IGBT (insulated gate bipolar transistor) are widely used in the application of motor drivers, switching supplies and other power conversion systems. The estimation of the power loss and junction temperature of semiconductor devices has become the major issue with the increase of the current density and high switching frequency of advanced power devices. The paper presents a partially coupled approach to evaluate the power loss and predict working temperature of switching devices. As an example IGBT PWM (pulse-width modulation) inverter is given to demonstrate the application of this approach. Based on the measurement of IGBTs dynamic characteristics, the estimation of power loss considering the junction temperature is introduced. Then the finite element analysis is used to accurate peak junction temperature prediction needed during dynamic operating conditions. In addition, the effect of switching frequencies during transient thermal response is investigated. The new approach developed can be used for accurate rating semiconductor devices or heat sink systems in power circuit design. Results comparison between proposed approach and commercial simulator shows that this approach is effective as a design step.
Propulsion system study for Small Transport Aircraft Technology (STAT) (1981)

Propulsion system technologies applicable to the generation of commuter airline aircraft expected to enter service in the 1990's are identified and evaluated in terms of their impact on aircraft operating economics and fuel consumption. The most promising technologies in the areas of engine, propeller, gearbox, and nacelle design are recommended for future research. Each item under consideration is evaluated relative to a modern baseline engine, the General Electric CT7-5, in a current technology aircraft flying a fixed range and payload. The analysis is presented for two aircraft sizes (30 and 50 passenger), over a range of mission lengths (100 to 1100 km) and fuel costs ($264 to $396 per cu m).
RoboEarth (2009)

In this paper, we present the core concept and the benefits of an approach called RoboEarth which will be highly beneficial for future robotic applications in science and industry. RoboEarth is a world-wide platform which robots can use to exchange position and map information as well as task-related, hardware-independent action recipes. This will enable manufacturers worldwide to break down their costs and efforts for reproducing software algorithms for robot behavior over and over again. The RoboEarth framework can store all relevant data from algorithms to complex behavior descriptions what allows robots to act autonomously in an unknown, unspecified environment. Especially in the field of interaction with humans RoboEarth can bring forward the behavior of robots and simplify the software design for developers in that field.
Automated Combination of Real-Time Shader Programs (2007)

This work proposes an approach for automatic and generic runtime-combination of high-level shader programs. Many of recently introduced real-time rendering techniques rely on such programs. The fact that only a single program can be active concurrently becomes a main conceptual problem when embedding these techniques into middleware systems or 3D applications. Their implementations frequently demand for a combined use of individual shader functionality and, therefore, need to combine existing shader programs. Such a task is often timeconsuming, error-prone, requires a skilled software engineer, and needs to be repeated for each further extension. Our extensible approach solves these problems efficiently: It structures a shader program into code fragments, each typed with a predefined semantics. Based on an explicit order of those semantics, the code fragments of different programs can be combined at runtime. This technique facilitates the reuse of shader code as well as the development of extensible rendering frameworks for future hardware generations. We integrated our approach into an object-oriented high-level rendering system.