gebhart/patrepeval huggingface dataset:
Caching considerations for generational garbage collection (1992)

article Free Access Share on Caching considerations for generational garbage collection Authors: Paul R. Wilson View Profile , Michael S. Lam View Profile , Thomas G. Moher View Profile Authors Info & Claims ACM SIGPLAN Lisp PointersVolume VIssue 1Jan. 1992 pp 32–42https://doi.org/10.1145/141478.141500Online:01 January 1992Publication History 44citation517DownloadsMetricsTotal Citations44Total Downloads517Last 12 Months10Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Dielectric response of high permittivity polymer ceramic composite with low loss tangent (2009)

The present communication investigates the dielectric response of the Sr9Ce2Ti12O36 ceramics loaded high density polyethylene and epoxy resin. Sr9Ce2Ti12O36 ceramic filled polyethylene and epoxy composites were prepared using hot blending and mechanical mixing, respectively. 40 vol % ceramic loaded polyethylene has relative permittivity of 12.1 and loss tangent of 0.004 at 8 GHz, whereas the corresponding composite using epoxy as matrix has permittivity and loss tangent of 14.1 and 0.022, respectively. The effective medium theory fits relatively well for the observed permittivity of these composites.
Phononic band gaps induced by inertial amplification in periodic media (2007)

In the literature, phononic band gaps in periodic media are generated via two different means, namely, Bragg scattering and local resonances. In this paper, an alternative method is introduced, in which effective inertia of the wave propagation medium is amplified via embedded amplification mechanisms. A prototype two-dimensional mass-spring lattice is introduced. The band structure of this lattice is computed for various instantiations to highlight the benefits of inertial amplification and to quantify the sensitivity of inertial amplification induced band gaps to parametric variations. It is shown that inertial amplification gives rise to very wide band gaps at low frequencies.
Real-Time Intrusion Detection for Ad Hoc Networks (2005)

A mobile ad hoc network is a collection of nodes that are connected through a wireless medium and form rapidly changing topologies. The widely accepted existing routing protocols designed to accommodate the needs of such self-organised networks do not address possible threats aimed at the disruption of the protocol itself. The assumption of a trusted environment is not one that can be realistically expected; hence several efforts have been made towards the design of a secure routing protocol for ad hoc networks. The main problems with this approach are that it requires changes to the underlying routing protocol and that manual configuration of the initial security associations cannot be completely avoided. We propose RIDAN, a novel architecture that uses knowledge-based intrusion detection techniques to detect, in real-time, attacks that an adversary can perform against the routing fabric of a mobile ad hoc network. Our system is designed to take countermeasures minimising the effectiveness of an attack and maintaining the performance of the network within acceptable limits. RIDAN does not introduce any changes to the underlying routing protocol since it operates as an intermediate component between the network traffic and the utilised protocol with minimum processing overhead. We have developed a prototype that was evaluated in AODV-enabled networks using the ns-2 network simulator.
Sex Differences in Growth Hormone (GH) Secretion by Rats Administered GH-Releasing Hexapeptide (1991)

The purpose of this study was to compare GH secretion after the administration of GH-releasing hexapeptide (GHRP-6) in conscious male and female rats. Plasma GH was significantly elevated in female rats (six of six) compared to male rats (three of six) 15 min after administration of a single sc injection of GHRP-6 (0.5 mg/kg). In male rats, GHRP-6 administration was associated with suppression of episodic GH secretion and desensitization to a second injection administered 6 h later, whereas in female rats, GH secretion occurred after both GHRP-6 injections. After 14 consecutive days of administering GHRP-6 twice per day, mean plasma GH concentrations in males decreased from 110 +/- 91 to 2.8 +/- 0.6 ng/ml (P less than 0.05) and in females increased from 170 +/- 53 ng/ml to 361 +/- 81 ng/ml (P less than 0.05). Desensitization to GHRP-6 in conscious male rats was not observed in pentobarbital-anesthetized male rats, suggesting that GHRP-6 administration enhanced somatostatin release in the conscious state. After 14 consecutive days of GHRP-6 administration, the mean pituitary GH concentration in female rats was significantly lower than that in male rats (5.1 +/- 0.2 vs. 12.9 +/- 1.2 micrograms/mg, respectively). Lower pituitary GH concentrations in females correlated with higher GH secretion after GHRP-6 administration. Desensitization to GHRP-6 in male rats is attributed to neurohumoral factors producing their unusual pattern of episodic GH secretion, and the response is probably not typical of other species.
A probabilistic method for the computation of testability of RTL constructs (2004)

Validation of RTL descriptions remains one of the principal bottlenecks in the circuit design process. Random simulation based methods for functional validation suffer from fundamental limitations and may be inappropriate or too expensive. In fact, for some circuits, a large number of vector is required in order to make the circuit reach hard to test constructs and obtains accurate values for their testability. In this work, we present a static, non-simulation based, method for the determination of the controllability of RTL constructs that is efficient and gives accurate feedback to the designers in what regards the presence of hard to control constructs in their RTL code. The method takes as input a Verilog RTL description, solves the Chapman-Kolmogorov equations that describe the steady-state of the circuit and outputs the computed values for the controllability of the RTL constructs. To avoid the exponential blow-up that results from writing one equation for each circuit state and solving the resulting system of equations, an approximation method is used. We present results showing that the approximation is effective and describe how the method can be used to bias a random test generator in order to achieve higher coverage using a smaller number of vectors.
Neighborhood based fast graph search in large networks (2011)

Complex social and information network search becomes important with a variety of applications. In the core of these applications, lies a common and critical problem: Given a labeled network and a query graph, how to efficiently search the query graph in the target network. The presence of noise and the incomplete knowledge about the structure and content of the target network make it unrealistic to find an exact match. Rather, it is more appealing to find the top-k approximate matches.
Cold acclimation induces changes in Arabidopsis tonoplast protein abundance and activity and alters phosphorylation of tonoplast monosaccharide transporters (2011)

Because they are immotile organisms, higher plants have developed efficient strategies for adaptation to temperature changes. During cold acclimation, plants accumulate specific types of solutes to enhance freezing tolerance. The vacuole is a major solute storage organelle, but until now the role of tonoplast proteins in cold acclimation has not been investigated. In a comparative tonoplast proteome analysis, we identified several membrane proteins with altered abundance upon cold acclimation. We found an increased protein abundance of the tonoplast pyrophosphatase and subunits of the vacuolar V-ATPase and a significantly increased V-ATPase activity. This was accompanied by increased vacuolar concentrations of dicarbonic acids and soluble sugars. Consistently, the abundance of the tonoplast dicarbonic acid transporter was also higher in cold-acclimatized plants. However, no change in the protein abundance of tonoplast monosaccharide transporters was detectable. However, a generally higher cold-induced phosphorylation of members of this sugar transporter sub-group was observed. Our results indicate that cold-induced solute accumulation in the vacuole is mediated by increased acidification of this organelle. Thus solute transport activity is either modulated by increased protein amounts or by modification of proteins via phosphorylation.
Error detection and handling in a superscalar, speculative out-of-order execution processor system (2002)

The HaL SPARC64 Processor, the first 64-bit SPARC-V9 architecture implementation, uses several techniques to ensure a high degree of system reliability, error detection, and error recovery. The CPU of the multi-chip module processor has a superscalar, speculative issue unit, and an out-of-order execution datapath. These two processor components complicate the maintenance of precise state in the event of errors. By exploiting the SPARC-V9 architectural features, and the micro-architecture for speculative execution, SPARC64 maintains precise state in the event of exceptions and errors, logs and reports errors, and facilitates error detection during full system bringup. The paper presents details of error detection and handling in the CPU, the cache system, and the Memory Management Unit(MMU). The HaL R1 system also implements a fault-secure memory system design. The memory system corrects all single-bit errors, detects double bit errors, detects single address line failures, and detects all single dynamic RAM (DRAM) chip failures. Certain debug features have been added to the system that are useful during system bring-up.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Abstract 684: Trifluoperazine modulates DNA damage-induced cell death in human lung cancer cells through inhibition of DNA repair, cell cycle delays, and augmentation of pro-apoptotic signaling (2010)

Abstract Trifluoperazine modulates DNA damage-induced cell death in human lung cancer cells through inhibition of DNA repair, cell cycle delays, and augmentation of pro-apoptotic signaling Resistance of human tumors to DNA damaging chemotherapy poses severe limitations to the efficacy of current available treatment. Small molecule compounds of the phenothiazine class, such as trifluoperazine (TFP), have documented chemosensitizing activities. We exposed human non-small cell lung cancer (NSCLC) cell lines to the DNA damaging drug bleomycin in the presence or absence of TFP, and studied potential differences with regard to DNA repair and cell death signaling. A colony formation assay showed that TFP significantly enhanced the cytotoxic potential of bleomycin, at doses achievable clinically. Bleomycin treatment resulted in a reversible arrest at the G2-M phase of the cell cycle. Notably, TFP delayed the repair of bleomycin-induced DNA double strand breaks (DSBs), causing higher residual levels of γH2AX 24 h after treatment. Despite the presence of unrepaired DNA DSBs, cells co-treated with bleomycin and TFP overcame the G2-M checkpoint arrest, as evidenced by the reappearance of the mitosis marker histone H3 phospho-Ser10 and reduction in CFSE fluorescence. This process, which is reminiscent of checkpoint adaptation, was associated with increased micronucleation and secondary arrest in G2-M phase during subsequent rounds of the cell cycle. Furthermore, the onset of secondary checkpoint arrest in cells co-treated with bleomycin and TFP coincided with the activation of pro-apoptotic Bak and Bax, and was followed by activation of caspase-3, which occurred preferentially in cells in the G2-M phase. In conclusion, we demonstrate here that the chemosensitizing effect of TFP in NSCLC cells involves interference with DNA DSBs repair, resulting in secondary G-M checkpoint arrest after initial checkpoint adaptation, and concomitant increases in pro-apoptotic signaling. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 684.
El Estado esencial: una nueva concepción del estado (1992)

En el Foro Internacional sobre el Desafio Neoliberal, que tuvo lugar en Bogota en abril ultimo, el senador colombiano Fernando Botero Zea dicto una importante conferencia cuya parte final, que concreta su planteamiento sobre la nueva concepcion del Estado moderno, reproducimos aqui.
The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. (1993)

T-cell activation is a consequence of the clonotypic T-cell antigen receptor (TCR) binding to an antigen followed by signal transduction via the invariant subunits of the TCR/CD3 complex. gamma delta TCR cells are a small subset of T cells that populate both the epithelial and lymphoid tissues and have unique antigen specificity and function. However, the composition of invariant chains within the gamma delta TCR/CD3 complex has not been well characterized. Here we report that, unlike the majority of alpha beta T cell, gamma delta T cells isolated from spleen and intestinal epithelial tissue express high levels of the gamma chain of the high-affinity receptor for IgE (Fc epsilon RI gamma) as one invariant subunit of their TCR/CD3 complex. Fc epsilon RI gamma exists as both a homodimer and a heterodimer associated with the TCR zeta chain. Moreover, stimulation of the gamma delta TCR results in rapid tyrosine phosphorylation of Fc epsilon RI gamma. Our results suggest that utilization of distinct receptor signaling components may enable the coupling of antigen stimulation to the activation of different signal transduction pathways in alpha beta and gamma delta T cells.
On the Dynamic Adaptability of Chinese Public Signs (2010)

This study aims to discuss the classification and description of current Chinese public signs and the dynamic adaptability in public signs designing. Based on the survey carried out in Ya Xing Residential Zone Zhengzhou city and Verschueren’s Theory of Linguistic Adaptation, the author attempts to analyze that public signs language is a choice-making process in adaptation to the constantly changing communicative context, the main components of which are changed physical conditions, social relationships and settings, and cognitive and emotional needs of the public.
Reconfigurable Hardware Operating Systems: From Design Concepts to Realizations (2003)

In this paper, we approach the rather new area of reconfigurable hardware operating systems in a top-down manner. First, we describe a design concept that defines basic abstractions and operating system services in a device-independent way. Then, we refine this model to an implementation concept on the Xilinx Virtex XCV-800 technology. The implementation concept proposes a multitasking environment that executes relocatable hardware tasks, uses a memory management unit translating task requests to internal and external memory accesses, and relies on device drivers and triggers to connect to external I/O. Finally, we present a prototypical implementation and an application case study. The application consists of a set of dynamically loaded and executed networking and multimedia tasks such as IP packet processing, AES decryption, and audio stream decoding.
Colloidal electroconvection in a thin horizontal cell. I. Microscopic cooperative patterns at low voltage (2005)

Applying an electric field to an aqueous colloidal dispersion establishes a complex interplay of forces among the highly mobile simple ions, the more highly charged but less mobile colloidal spheres, and the surrounding water. This interplay can induce a wide variety of visually striking dynamical instabilities even when the applied field is constant. This paper reports on the highly organized patterns that emerge when electrohydrodynamic forces compete with gravity in thin layers of charge-stabilized colloidal spheres subjected to low voltages between parallel-plate electrodes. Depending on the conditions, these spheres can form levitating clusters with morphologies ranging from tumbling clouds to toroidal vortex rings and to writhing labyrinths.
Steerable miniature legged robot driven by a single piezoelectric bending unimorph actuator (2017)

In small mobile robots, decreasing the number of actuators is usually desirable to reduce the size and weight of the robot, but it is usually at the expense of the robot's degree of freedom (DOF). This work presents the development and preliminary experimental testing of a novel Legged Piezoelectric Miniature Robot (LPMR) driven only by a single piezoelectric unimorph actuator and yet fully capable of being maneuvered to move forward, turn right, or turn left. The underactuated motion is achieved by exploiting the bending vibration modes disparity of the piezoelectric actuator at different driving frequencies and designing specific positions of the robot's legs to generate a differential-drive-like mechanism. The speed of the robot can be controlled through regulating the magnitude of the applied voltage. The proposed underactuated system is experimentally verified and a preliminary characterization of the LPMR in terms of its forward and turning speed versus applied voltage and payload is investigated and reported.
Early prostate cancer: Radical prostatectomy or watchful waiting? (2006)

Critically appraised article: Bill-Axelson A,Holmberg L, Ruutu M, Haggman M,Andersson SO, Bratell S, Spangberg A,Busch C, Nordling S, Garmo H, PalmgrenJ, Adami HO, Norlen BJ, Johansson JE;Scandinavian Prostate Cancer GroupStudy No. 4. Links Radical prostatectomyversus watchful waiting in early prostatecancer. N Engl J Med 2005; 352: 1977-84.
1-μm-pumped OPO based on orientation-patterned GaP (2015)

Orientation patterned gallium phosphide (OP-GaP) is a new nonlinear optical (NLO) crystal which exhibits the highest nonlinear coefficient (d<sub>14</sub>=70.6 pm/V) and the longest infrared cut-off (12.5 μm) of any quasi-phase-matched (QPM) material that can be pumped at 1-μm without significant two-photon absorption. Here we report the first 1064nm-pumped OPO based on bulk OP-GaP. Multi-grating OP-GaP QPM structures were grown by producing an inverted GaP layer by polar-on-nonpolar molecular beam epitaxy (MBE), lithographically patterning, reactive ion etching, and regrowing by MBE to yield templates for subsequent bulk growth by low-pressure hydride vapor phase epitaxy (LP-HVPE). The pump source was a diode-end-pumped Nd:YVO<sub>4</sub> monoblock laser with an RTP high-voltage Q-switch (1064 nm, 1W, 10kHz, 3.3 ns) which was linearly polarized along the <100> orientation of the AR-coated 16.5 x 6.3 x 1.1 mm<sup>3</sup> OP-GaP crystal (800-μm thick HVPE layer, 20.8 μm grating period only 150 μm thick) mounted on a copper blocked maintained at 20°C by a thermo-electric cooler. The OPO cavity was a linear resonator with 10-cm ROC mirrors coated for DRO operation (85%R at signal, 55%R at idler). The pump 4σ-diameter at the crystal face was 175 μm. The observed OPO signal (idler) threshold was 533 mW (508 mW) with a slope efficiency of 4% (1%) and maximum output power 15 mW (4 mW). The signal (1342 nm) and idler (4624 nm) output wavelengths agreed well with sellemier predictions. Orange parasitic output at 601.7nm corresponded to 9<sup>th</sup> order QPM sum frequency mixing of the 1064-nm pump and the 1385-nm signal.
Multivariate Stratified Metal–Organic Frameworks: Diversification Using Domain Building Blocks (2019)

We introduce the concept of domain building blocks (DBBs) as an effective approach to increasing the diversity and complexity of metal-organic frameworks (MOFs). DBBs are defined as distinct structural or compositional regions within a MOF material. Using the DBB approach, we illustrate how an immense number of multivariate MOF materials can be prepared from a small collection of molecular building blocks comprising the distinct domains. The multivariate nature of the MOFs is determined by the sequence of DBBs within the MOF. We then apply this approach to the construction of a rich library of UiO-67 stratified MOF (sMOF) particles consisting of multiple concentric DBBs. We discuss and highlight the negative consequences of linker exchange reactions on the compositional integrity of DBBs in the UiO-67 sMOFs and propose and demonstrate mitigation strategies. We also demonstrate that individual strata can be specifically postsynthetically addressed and manipulated. Finally, we demonstrate the versatility of these synthetic strategies through the preparation of sMOF-nanoparticle composite materials.
The Important Role of Osteoblasts and Citrate Production in Bone Formation: “Osteoblast Citration” as a New Concept for an Old Relationship (2012)

It has been known for about seventy years that bone, in all vertebrates, contains uniquely high citrate levels. However, the role of citrate, its source, its regulation, and its implication in normal bone formation and in bone disorders have remained largely unknown. For the past thirty-five years, the relationship of citrate in bone has been a neglected area of attention and research. It has recently been discovered that citrate is critical for the structure of the apatite nanocrystal, and is required to impart the important properties of bone such as its stability, strength, and resistance to fracture. This brings to focus the need for a renewed interest and research into the relationships of citrate in bone formation. A most fundamental question that must be resolved is "What is the source of citrate in bone?". This presentation provides a historical review of the early research to the present status of citrate implications in bone. This leads to a new concept of the role of osteoblasts as specialized citrate producing cells that provide the source of citrate in bone formation; i.e. the "osteoblast citration" process. This also brings into focus a new insight into the role of zinc in bone in relation to osteoblast citrate production. The genetic/hormonal/metabolic relationships of "net citrate production" are described. The intent of this presentation is to provide the background for a new perspective of the important implications of osteoblasts and citrate in bone formation; which, hopefully, will stimulate a renewed interest and essential research.