gebhart/patrepeval huggingface dataset:
Apolipoprotein B is conformationally flexible but anchored at a triolein/water interface: A possible model for lipoprotein surfaces (2006)

Apolipoprotein B (apoB) is one of a unique group of proteins that form and bind to fat droplets, stabilize the emulsified fat, and direct their metabolism. ApoB, secreted on lipoproteins (emulsions), remains bound during lipid metabolism yet exhibits conformational flexibility. It has amphipathic beta-strand (AbetaS)-rich domains and amphipathic alpha-helix (AalphaH)-rich domains. We showed that two consensus AbetaS peptides of apoB bound strongly to hydrophobic interfaces [triolein/water (TO/W) and dodecane/water], were elastic, and were not pushed off the interface when the surface was compressed. In contrast, an AalphaH peptide modeling helical parts of apoB was forced off the TO/W interface by compression and readsorbed when the interface was expanded. In this report, the surface behavior of apoB-100 was studied at the TO/W interface. Solubilized apoB lowered the interfacial tension of TO/W in a concentration-dependent fashion. At equilibrium tension, if the surface was compressed, part of apoB was pushed off but quickly readsorbed when the surface was expanded. Even when the surface area was compressed by approximately 55%, part of the apoB molecule remained bound. The maximum surface pressure that apoB could withstand without being partially ejected was 13 mN/m. ApoB showed high elasticity at the TO/W interface. Based on studies of the consensus AbetaS and AalphaH peptides, we suggest that AbetaSs anchor apoB and are its nonexchangeable motif, whereas its conformational flexibility arises from both the elastic nature of the AbetaS and the ability of AalphaH domains of the molecule to desorb and readsorb rapidly in response to surface pressure changes.
Description of Caldanaerobius fijiensis gen. nov., sp. nov., an inulin-degrading, ethanol-producing, thermophilic bacterium from a Fijian hot spring sediment, and reclassification of Thermoanaerobacterium polysaccharolyticum and Thermoanaerobacterium zeae as Caldanaerobius polysaccharolyticus comb. nov. and Caldanaerobius zeae comb. nov. (2008)

An obligately anaerobic, spore-forming, Gram-type-positive but Gram-staining-negative thermophilic bacterium, strain JW/YJL-F3(T), was isolated from a Fijian hot spring sediment sample. Cells of strain JW/YJL-F3(T) were straight to slightly curved rods, 0.5-1.2 microm in diameter and 1.5-19 microm long. The temperature range for growth was between 40 and 67 degrees C, with an optimum at 60-63 degrees C. The pH(25 degrees C) range for growth was 4.5-8.4 with an optimum of 6.8. The salinity range for growth was 0-0.5 %. Strain JW/YJL-F3(T) utilized a range of substrates including arabinose, cellobiose, galactose, glucose, inulin, lactose, maltose, mannose, raffinose, ribose, trehalose, xylose and yeast extract as carbon and energy sources. The major fermentation end products from glucose were ethanol, acetate and formate. Strain JW/YJL-F3(T) converted thiosulfate to elemental sulfur, producing sulfur globules. The DNA G+C content was 37.6 mol% as determined by HPLC. Phylogenetic analysis using the 16S rRNA gene sequence indicated that the isolate is distantly related to the clade of the genus Thermoanaerobacterium. However, Thermoanaerobacterium polysaccharolyticum (96.7 % similarity to the type strain) and Thermoanaerobacterium zeae were the closest relatives, forming a separate, well-supported clade together with the novel isolate. Because Thermoanaerobacterium polysaccharolyticum, Thermoanaerobacterium zeae and strain JW/YJL-F3(T) have different features from other Thermoanaerobacterium species, including a higher G+C content and formate production, and are placed distantly from the remaining species of Thermoanaerobacterium (greater than 10 % distance) in the 16S rRNA gene sequence analysis, we propose to place the new isolate JW/YJL-F3(T) and Thermoanaerobacterium polysaccharolyticum and Thermoanaerobacterium zeae into the novel genus Caldanaerobius gen. nov. as Caldanaerobius fijiensis gen. nov., sp. nov. (the type species), Caldanaerobius polysaccharolyticus comb. nov. and Caldanaerobius zeae comb. nov., respectively. The type strain of Caldanaerobius fijiensis is JW/YJL-F3(T) (=ATCC BAA-1278(T) =DSM 17918(T)).
On the positioning of multisensor imagery for exploitation and target recognition (1997)

Modern image exploitation tasks have evolved from the early single-image, pixel-based and model-less methods to the current multi-image, multisensor, multiplatform, and model-based approaches. In this context, image positioning, which is the process of establishing the precise geometric relationship of an acquired image to the three-dimensional (3-D) world, has become an enabling technique for state-of-the-art multisensor data exploitation. Precise image positioning provides several benefits. Image registration, traditionally formulated as an image-to-image alignment problem, can now be carried out in accordance with interior and exterior sensor geometries. Images from sensors in arbitrary locations and orientations can be positioned with respect to a focal vertical and geocentric coordinate systems. This paper presents techniques for positioning images derived from various sensors such as electro-optical (E-O), synthetic aperture radar (SAR), and interferometric synthetic aperture radar (IFSAR). Applications to model-supported image exploitation are also discussed.
Diagnosis of Chronic Myelogenous Leukemia in a Dog Using Morphologic, Cytochemical, and Flow Cytometric Techniques (2001)

Chronic myelogenous leukemia was diagnosed in a 3.5-year-old neutered male Golden Retriever. The diagnosis was based on persistent leukocytosis (>73.0X10(3)/microliter), composed of a proportionate left shift to progranulocytes with no evidence of underlying inflammation, infection, or neoplasia. Marked dysplasia was evident in neutrophils and platelets in peripheral blood. Bone marrow and splenic aspirates were dominated by mature and immature neutrophils with < 2% myeloblasts. Cytochemical and flow cytometric assays confirmed that cells in the peripheral blood and spleen were of committed neutrophil lineage. The dog responded initially to treatment with hydroxyurea, but developed acute undifferentiated leukemia approximately 83 days after initial presentation.
Observations on dynamic tensions of drill string during drilling operations of scientific drilling vessel Chikyu (2009)

The scientific drilling vessel Chikyu began scientific drilling at the Nankai Trough in 2007 via a system integration drilling test off Shimokita. To attain success in deep drilling and coring, one of the important issues is to ensure the strength of the drill pipes. During drilling operations, various forces are exerted on the drill pipe, such as dynamic tension due to vessel heave as well as bending stress due to vessel movement and ocean current. During the design phase, strength evaluation of the drill pipe is conducted under several assumptions. To ensure the strength of the drill pipe, it is important to utilize data acquired from actual drilling operations and to verify the analysis model. Therefore, we acquired drilling data such as vessel motion and hook load during drilling operations. By utilizing the drilling data, the dynamic tension can be estimated and the analysis model can be verified. Furthermore, with the dynamic tension estimated from the acquired data, the weight on bit variation can be estimated. In addition, the occurrence of buckling modeled with parameters such as the weight on bit and drill pipe specifications is discussed. Of course, if there are unexpected phenomena, these can be observed using the drilling data.
Increased Production of Tank‐Reared Macrobrachium rosenbergii THROUGH USE OF ARTIFICIAL SUBSTRATES<sup>1</sup> (1975)

ABSTRACT The giant Malaysian prawn, Macrobrachium rosenbergii (de Man), is aggressive and cannibalistic when reared at high densities. In two experiments use of artificial substrates was tested as a means of increasing production. In experiment I, after 4 weeks average prawn mortality was 4 times greater in tanks (95 liters) not containing substrates than in tanks fitted with five‐tiered horizontal substrate units. In experiment II the effects of substrates and substrate configuration on prawn production were examined in larger tanks (2.2 kl). Prawns reared in tanks containing either the horizontal or vertical substrates grew faster and had a higher survival than those reared in tanks not containing the substrates. In addition, feed utilization was less efficient and cannibalism became apparent at a much smaller size among prawns reared in tanks without substrates. Biomass production and survival were slightly greater among prawns reared in tanks containing a horizontal substrate configuration than among prawns in the vertical configuration.
[From the Editor] (1950)

Other| October 01 1950 [From the Editor] The Editor The Editor Search for other works by this author on: This Site PubMed Google Scholar Journal of the Society of Architectural Historians (1950) 9 (3): 3. https://doi.org/10.2307/987454 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation The Editor; [From the Editor]. Journal of the Society of Architectural Historians 1 October 1950; 9 (3): 3. doi: https://doi.org/10.2307/987454 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentJournal of the Society of Architectural Historians Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Amplification of c‐erbB2 oncogene (2005)

HER-2/neu gene amplification in USPC was found to be an important prognostic indicator for poor outcome that occurs more frequently in AA when compared with C patients. Determination of HER-2/neu gene amplification may guide clinical management of patients with USPC and may have important implications for the implementation of novel treatment strategies.
Mechanism for Proton Conduction of the M2 Ion Channel of Influenza A Virus (2000)

The M(2) integral membrane protein of influenza A virus forms a proton-selective ion channel. We investigated the mechanism for proton transport of the M(2) protein in Xenopus oocytes using a two-electrode voltage clamp and in CV-1 cells using the whole cell patch clamp technique. Membrane currents were recorded while manipulating the external solution to alter either the total or free proton concentration or the solvent itself. Membrane conductance decreased by approximately 50% when D(2)O replaced H(2)O as the solvent. From this, we conclude that hydrogen ions do not pass through M(2) as hydronium ions, but instead must interact with titratable groups that line the pore of the channel. M(2) currents measured in solutions of low buffer concentration (<15 mM in oocytes and <0.15 mM in CV-1 cells) were smaller than those studied in solutions of high buffer concentration. Furthermore, the reversal voltage measured in low buffer was shifted to a more negative voltage than in high buffer. Also, at a given pH, M(2) current amplitude in 15 mM buffer decreased when pH-pK(a) was increased by changing the buffer pK(a). Collectively, these results demonstrate that M(2) currents can be limited by external buffer capacity. The data presented in this study were also used to estimate the maximum single channel current of the M(2) ion channel, which was calculated to be on the order of 1-10 fA.
Aspirin Induces Apoptosis through the Inhibition of Proteasome Function (2006)

Aspirin and other nonsteroidal anti-inflammatory drugs inhibit cell proliferation and induce apoptosis in various cancer cell lines, which is considered to be an important mechanism for their anti-tumor activity and prevention of carcinogenesis. However, the molecular mechanisms through which these compounds induce apoptosis are not well understood. Here we have found that aspirin treatment of the mouse Neuro 2a cells impaired the proteasome function and caused severe mitochondrial abnormalities. Treatment with aspirin lead to a dose- and time-dependent decrease in proteasome activity and an increase in the accumulation of ubiquitylated proteins in the cells, which correlated with its effect on cell death. Aspirin exposure also resulted in an increase in the half-life of pd1EGFP, a model substrate of proteasome, as well as various intracellular substrates like Bax, IkappaB-alpha, p53, and p27(kip1). Aspirin-induced proteasomal malfunction might be responsible, at least in part, for the down-regulation of NF-kappaB activity and neurite outgrowth. Finally, we have shown that aspirin treatment caused changes in the mitochondrial membrane potential, release of cytochrome c from mitochondria, and activation of caspase-9 and -3, which could be because of the proteasomal dysfunction.
Roger C. Lyndon. Groups and geometry (London Mathematical Society Lecture Note Series 101, Cambridge University Press, 1985), 217 pp. £11.95. (1985)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Chitosan-modified, collagen-based biomimetic nanofibrous membranes as selective cell adhering wound dressings in the treatment of chemically burned corneas (2014)

Corneal chemical injury is a general but intractable ocular emergency, the sequelae of which are particularly challenging to treat. Human amniotic membrane (HAM) is one of the resources as a wound dressing for damaged corneal reconstruction, but the concerns related to the possible transmission of infectious diseases are the main drawbacks. Here we present a versatile method utilizing electrospinning and surface modification processes to develop optically highly transparent, microstructurally stable (>20 MPa in tensile strength in the wet state) biomimetic nanofibrous membranes. These membrane nanofibers, mainly consisting of a collagen-hyaluronate interior and a chitosan surface coating, showed superior mechanical and biological performances compared to HAM, and were favorable to the selective adhesion of epithelial cells (corneal, conjunctival) and fibroblasts. The alkali-burned corneal damage model in rats demonstrated that the biomimetic membranes could markedly improve re-epithelialization in corneal tissue within one week. Therefore, such bioactive multifunctional membranes may find widespread biomedical applications in wound healing and postoperative anti-adhesion in the near future.
Reactive power limits in distributed generators from generic capability curves (2014)

This paper presents a generic trapezoid-type capability curve for any distributed generation technology. This curve is used to estimate the machine reactive power limits in terms of the actual active power and terminal voltage. The proposed simplification was tested on synchronous machines, doubly fed induction generators and full power converter interfaced generators. This methodology can be implemented in Volt/VAR control schemes when the estimation of DG capability is required.
Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury (1998)

Transcription factor c-Jun is proposed to control neuronal cell death and survival, but its activation by N-terminal phosphorylation and the underlying activity of the c-Jun N-terminal kinases (JNKs) remain to be elucidated in the adult mammalian brain. We generated a polyclonal antiserum that specifically recognizes c-Jun phosphorylated at its serine 73 (S73) residue after UV irradiation of 3T3 cells. Disruption of the c-jun locus in 3T3 cells abolished this reaction, and retransfection of the human c-jun at the c-jun-/- background restored it. The phospho-c-Jun antiserum was used to visualize N-terminally phosphorylated c-Jun in the adult rat brain with cellular resolution. Prolonged c-Jun S73 phosphorylation was detected in affected neurons up to 5 d after transient occlusion of medial cerebral artery or up to 50 d after transection of central nerve fiber tracts. After cerebral ischemia-reperfusion, phosphorylation of c-Jun was linked with induced expression of Fas-ligand (APO-1, CD95-ligand), whose gene is a putative c-Jun/AP-1 target, and with terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling (TUNEL) reactivity, a marker for apoptosis. After nerve fiber transection, however, lasting c-Jun phosphorylation occurred in axotomized neurons negative for Fas-ligand or TUNEL and regardless of degeneration or survival. In contrast to these lasting phosphorylation patterns, transient seizure activity by pentylenetetrazole provoked only a brief c-Jun phosphorylation and JNK activation. In extracts from ischemic or axotomized brain compartments, c-Jun phosphorylation correlated with enhanced long-term JNK activity, and in-gel kinase assays visualized proteins with sizes corresponding to JNK isoforms as the only c-Jun N-terminally phosphorylating enzymes. These results demonstrate that lasting c-Jun S73 phosphorylation and JNK activity are part of neuronal stress response after neurodegenerative disorders in the adult mammalian brain with Fas-ligand as a putative apoptotic effector.
Standardizing the Medical Data in China by CDA (2009)

With wide range of applications of EMR in the medical and health industry, the standardization of medical data has become a major bottleneck of the medical and health informationization. This paper proposes a method of standardizing the medical data by CDA using XML. The output of the semantic concept tree can be widely used for further research on analysis of EMR, data mining in EMR, information integration and sharing in hospital internal system and medical institutions.
El Carmelo en la concepción poética de José Lezama Lima (2010)

Uno de los aspectos centrales en la obra de Jose Lezama Lima es su barroquismo. Pero entre las lineas de su obra, se esconde junto a este gongorismo y barroquismo aparente, el aliento de la vida y obra de los misticos carmelitas San Juan de la Cruz y Santa Teresa de Jesus. Es desde esta encrucijada desde la que se produce y provoca la confluencia con las poeticas de otros autores como Juan Ramon Jimenez o Jose Angel Valente, poetas de la palabra, misticos de la nada.
Two different intrachain cAMP binding sites of cAMP-dependent protein kinases. (1980)

The regulatory subunits of both isozymes of cAMP-dependent protein kinase bind 2 mol of cAMP/mol of monomer. cAMP dissociation studies indicate similar cAMP binding behavior for each isozyme. Each has two different intrachain cAMP binding components present in approximately equal amounts and the rate of cAMP dissociation is 5- to 10-fold slower from one site (Site 1) than from the other (Site 2). Equilibrium [3H]cAMP binding is inhibited by several competing cyclic nucleotides. Following equilibrium binding using saturating [3H]cAMP in the presence of competing nucleotide, the pattern of release of [3H]cAMP, monitored in the presence of an excess of nonradioactive cAMP, suggests site-specific selectivity of some of the cyclic nucleotides. As compared with cAMP, cIMP prefers Site 2 for both regulatory subunits, whereas N6, O2-dibutyryl-cAMP shows a similar preference only with isozyme II regulatory subunit. 8-Bromo-cAMP, 8-bromo-cGMP, and 8-azido-cAMP prefer Site 1 of both proteins. The results indicate that for each isozyme the two intrachain binding sites have different analogue specificities and cAMP dissociation rates. Site 1 or Site 2 of one isozyme has a similar but not identical cyclic nucleotide specificity and cAMP dissociation rate to the corresponding site of the other isozyme.
Multiscale Markov random fields for large image datasets representation (2002)

Future users of satellite images will be faced with a huge amount of data. The development of "content-based image retrieval algorithms for remote sensing image archives" will allow them to efficiently use the upcoming databases of large images. The authors present an image segmentation and feature extraction algorithm, that will enable users to search images by content. In their approach, images are modelled by multiscale Markov random fields (MSRF). This model is superior to spatial Markov random field models in that it is able to describe the long range as well as the short range behaviour of the image data. Image information extracted at multiple scales is incorporated naturally in the model. Additionally it is computationally less costly than the spatial random field models. The difference to similar work by Ch.A. Bouman et al. (1994) and A. Jain et al. (1992) is that the multiscale process is not only used to find a reasonable segmentation of the image, but that the estimated parameters of the scale process serve also as image features. These image features together with the textural characteristics of the image are stored hierarchically in a pyramidal structure from large to small scales. Thereby even large datasets can be quickly browsed.
Activation of human T lymphocytes by bryostatin. (1988)

The immunologic effects of bryostatin (Bryo), a PKC activator with antineoplastic activity, were assessed and compared to PMA. Bryo induced IL-2R expression on CD4+ and CD8+ human T lymphocytes with a dose response comparable to PMA. However, Bryo induced only a marginal proliferative response as compared with the vigorous response induced by PMA. Bryo mediated functional receptor expression because the proliferative response was enhanced by addition of rIL-2. Furthermore, the proliferative response was inhibited by the relatively specific Ca+, phospholipid-dependent protein kinase (PKC) inhibitor, H-7, indicating a role of PKC in Bryo-induced activation. Addition of the calcium ionophore, ionomycin, to Bryo-stimulated lymphocytes resulted in the production and secretion of IL-2 with a concomitant proliferative response. This effect of the calcium ionophore could be inhibited by cyclosporine with identical results obtained in PMA-stimulated cultures. A most intriguing finding was that Bryo could effectively antagonize PMA-induced T cell proliferation. Although this mechanism of inhibition is unclear, a discussion with respect to differential effects on potential intracellular PKC isoforms is provided. These studies indicated that Bryo has potent immunopotentiating properties that share some similar effects of the phorbol ester, PMA, but offers the additional property of modulating other phorbol ester effects on proliferation.
New instruments for penetrating the abdominal wall. An engineering approach (1993)

A brief description is given of three instruments which are being developed for penetrating the abdominal wall. Designs are based on engineering concepts rather than medical ones and evaluation by surgeons is essential.