gebhart/patrepeval huggingface dataset:
Surface and interface stress effects in thin films (1994)

Surface and interface stresses in solids are defined and their role in the thermodynamics of solids is presented. A discussion concerning the physical meaning of these quantities is given, along with a review of selected theoretical calculations and experimental measurements. It is shown that for a solid phase with one or more of its dimensions smaller than about 10 nm, the surface and interface stresses can be principal factors in determining the equilibrium structure and behavior of the solid. In particular, the effects of surface and interface stresses on thin films are reviered along with the related topic of surface reconstructions in metals.
Converting Topology Optimization Results into Parametric CAD Models (2009)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Phishing Detection: Analysis of Visual Similarity Based Approaches (2017)

Phishing is one of the major problems faced by cyber-world and leads to financial losses for both industries and individuals. Detection of phishing attack with high accuracy has always been a challenging issue. At present, visual similarities based techniques are very useful for detecting phishing websites efficiently. Phishing website looks very similar in appearance to its corresponding legitimate website to deceive users into believing that they are browsing the correct website. Visual similarity based phishing detection techniques utilise the feature set like text content, text format, HTML tags, Cascading Style Sheet (CSS), image, and so forth, to make the decision. These approaches compare the suspicious website with the corresponding legitimate website by using various features and if the similarity is greater than the predefined threshold value then it is declared phishing. This paper presents a comprehensive analysis of phishing attacks, their exploitation, some of the recent visual similarity based approaches for phishing detection, and its comparative study. Our survey provides a better understanding of the problem, current solution space, and scope of future research to deal with phishing attacks efficiently using visual similarity based approaches.
Security, ID Systems and Locks: The Book on Electronic Access Control (1997)

From the Publisher:
Security, ID Systems and Locks will teach you how to:
* Work with consultants
* Negotiate with dealers
* Select communications options
* Understand what computer professionals are saying
* Provide better security

About The Author
Written in clear and simple terms, Security, ID Systems and Locks provides the security professional with a complete understanding of all aspects of electronic access control. Each chapter includes important definitions, helpful study hints, highlighted review, and application questions. Throughout the book, the reader will find advice from security professionals, computer wizards, and seasoned trainers. Topics include a history of access control, modern ID technology, locks, barriers, sensors, computers, wiring, communications, and system design and integration. Money-saving coupons for training programs in access control are included.

About The Author
Karen Little, a technical writer and trainer, has been president of Clear Concepts since 1992. She provides research, writing, and illustrations for technical documentation, training manuals, Web sites, and interactive multimedia.
LATTICE LOCATION OF DOPANT ELEMENTS IMPLANTED INTO Ge (1968)

The orientation dependence of the backscattered yield of 1.8-MeV carbon ions has been used to determine the lattice location of In, Tl, Sb, Bi, and Pb ions implanted into Ge at 30–40 keV and at temperatures between 300° and 350°C. Similar to the behavior in silicon, the group IV and V elements are found to be highly substitutional. Thallium exhibits nearly equal numbers of atoms in the 〈111〉 interstitial sites and on the substitutional sites (as in Si). In indium implants, on the other hand, we find no evidence of the clearly defined interstitial component previously seen in Si. In all cases, we observe substitutional concentrations orders of magnitude above thermal equilibrium solubilities.
A sept-branch modular multilevel converter for three-phase to single-phase direct AC/AC equal frequency conversion (2017)

For medium- to high-voltage AC/AC conversion applications, direct AC/AC conversion scheme by adopting the modular multilevel converter (MMC) shows remarkable advantages on costs and efficiency compared with the AC/DC/AC solution which employs a back-to-back MMC configuration. However, direct AC/AC MMC suffers from branch energy instability when conversion frequencies of input and output are equal. This paper presents a sept-branch MMC (SB-MMC) topology for direct AC/AC conversion applications. The feature of this SB-MMC is its capability of direct AC/AC equal frequency conversion from three-phase to single-phase and vice versa. Balanced branch energy and unity power factor at grid side can be achieved simultaneously under various load conditions. Operating principle as well as control strategy of the SB-MMC are described. Simulation on a 27.5kV/50MVA SB-MMC model for railway power supply is carried out. Simulation results validate the effectiveness of the SB-MMC and the proposed control strategy as well.
Structural and Molecular Basis of the Role of Starch and Sucrose in <i>Streptococcus mutans</i> Biofilm Development (2008)

The interaction of sucrose and starch with bacterial glucosyltransferases and human salivary amylase may enhance the pathogenic potential of Streptococcus mutans within biofilms by influencing the structural organization of the extracellular matrix and modulating the expression of genes involved in exopolysaccharide synthesis and specific sugar transport and two-component systems.
<i>Pantoea:</i>insights into a highly versatile and diverse genus within the Enterobacteriaceae (2015)

The bacterial genus Pantoea comprises many versatile species that have been isolated from a multitude of environments. Pantoea was delineated as a genus approximately 25 years ago, but since then, approximately 20 species have been identified having a diversity of characteristics. Isolates from water and soil have been harnessed for industrial purposes including bioremediation, and the degradation of herbicides and other toxic products. Other isolates possess nitrogen fixation and plant growth-promoting capabilities, which are currently being explored for agricultural applications. Some isolates are antibiotic producers, and have been developed into biocontrol agents for the management of plant diseases. Pantoea is also known to form host associations with a variety of hosts, including plants, insects and humans. Although often thought of as a plant pathogen, recent evidence suggests that Pantoea is being frequently isolated from the nosocomial environment, with considerable debate as to its role in human disease. This review will explore this highly versatile group and its capabilities, its known associations, and the underlying genetic and genomic determinants that drive its diversity and adaptability.
Processing of an HIV Replication Intermediate by the Human DNA Replication Enzyme FEN1 (1998)

The role of human FEN1 (flap endonuclease-1), an RTH1 (RAD two homolog-1) class nuclease, in the replication of human immunodeficiency virus (HIV) type 1 has been examined using model substrates. FEN1 is able to endonucleolytically cleave a primer annealed to a template, but with a 5'-unannealed tail. The HIV (+)-strand is synthesized as two discontinuous segments, with the upstream segment displacing the downstream segment to form a central (+)-strand overlap. Given a substrate with the exact HIV nucleotide sequence, FEN1 was able to remove the overlap. After extension of the upstream primer with DNA polymerase epsilon, human DNA ligase I was able to complete the continuous double strand as would occur for an integrated provirus. FEN1 may represent a target for new therapeutic interventions.
Integrin-Mediated Collagen Matrix Reorganization by Cultured Human Vascular Smooth Muscle Cells (1995)

Vascular smooth muscle cells perform the important function of modulation of vascular extracellular matrix. Because integrins mediate many cell-matrix interactions, the role of integrins in reorganization of collagen by cultured human vascular smooth muscle cells was studied. Immunoprecipitation demonstrated that human vascular smooth muscle cells express multiple beta 1 integrins. Monoclonal antibody A2-IIE10 (a blocking anti-alpha 2 antibody) inhibited adhesion of smooth muscle cells to collagen by 31%. The blocking anti-alpha 1 antibody 1B3.1 inhibited adhesion by 40%, whereas a blocking anti-alpha 3 antibody had no effect on adhesion. When 1B3.1 and A2-IIE10 were both used, a 79% reduction in adhesion was observed, indicating that active alpha 1 and alpha 2 integrins cooperatively mediate adhesion. The blocking anti-beta 1 antibody Mab13 abolished smooth muscle cell-mediated gel contraction, and the alpha 2-blocking antibody A2-IIE10 had a dose-dependent partial inhibitory effect (37%). In contrast, blocking antibodies to alpha 1 and alpha 3 had no effect. When anti-alpha 1 (1B3.1) and anti-alpha 2 (A2-IIE10) monoclonal antibodies were combined, no synergistic effect on inhibition of gel contraction was observed. Surprisingly, collagen gel contraction was inhibited by 46% by an anti-beta 1 antibody (TS2/16) known for its stimulatory effect on cell adhesion. Thus, whereas alpha 1 beta 1 and alpha 2 beta 1 integrins both participate in adhesion of vascular smooth muscle cells to collagen, only alpha 2 beta 1 integrins mediate collagen reorganization. In addition, collagen reorganization appears to be a dynamic process, adversely affected by excessive adhesion strengthening.
Multicast Complement for Efficient UPnP Eventing in Home Computing Network (2007)

The UPnP technology is widely employed to enable networked devices interconnected in home computing environments. The UPnP eventing protocol on top of HTTP over TCP performs in a unicast manner, however, suffering from scalability problem and performance degradation against highly frequent event notifications. This paper devises an efficient event multicast mechanism to mitigate above circumstances. The proposed mechanism can group service subscribers of the same access interest and synchronously inform all subscribers in a group of event notifications through a specific administratively scoped multicast delivery. Its design is compliable with GENA specification and so is able to coexist with the original UPnP eventing method. The experimental prototype shows that this mechanism is lightweight and does not complicate the UPnP system design.
Novel Phenolic Antioxidants as Multifunctional Inhibitors of Inducible VCAM‐1 Expression for Use in Atherosclerosis. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Preventive and therapeutic effects in rats of hepatocyte growth factor infusion on liver fibrosis/cirrhosis (1997)

Liver fibrosis/cirrhosis is characterized by hyper-accumulation of fibrous tissue components and is commonly observed in later or terminal states of chronic hepatic diseases. In ongoing work, we found that the administration of human recombinant hepatocyte growth factor (hrHGF) suppressed the onset of liver fibrosis/cirrhosis in several distinct models and accelerated the recovery from liver fibrosis/cirrhosis in rats. Repeated administration of porcine serum for 10 weeks to rats induced liver fibrosis without any accompanying hepatocellular injuries; in addition, the intravenous (i.v.) administration of hepatocyte growth factor (HGF) to these rats suppressed increases in fibrous components and hydroxyproline contents in the liver, thus preventing the onset of liver fibrosis. Repeated administration of dimethylnitrosamine (DMN) for four weeks induced liver cirrhosis, as characterized by the hyper-accumulation of fibrous components, infiltration of mononuclear leukocytes, and hepatic dysfunction. When HGF was injected daily for four weeks along with DMN-treatment, the onset of DMN-induced hepatic fibrosis/cirrhosis was suppressed; the numbers of infiltrating mononuclear cells, fibrous tissue components, and hydroxyproline content in the liver were decreased. When HGF was injected for two weeks following four weeks of DMN-treatment, HGF accelerated the recovery from liver cirrhosis and prevented death due to hepatic dysfunction. Likewise, HGF-injection suppressed the onset of liver fibrosis, when liver fibrosis had been induced by long-term treatment with carbon tetrachloride (CCl4). Thus, the administration of HGF holds great promise for treating subjects with liver fibrosis/cirrhosis as a result of chronic hepatic injury.
Nonarteritic Anterior Ischemic Optic Neuropathy and Sildenafil (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Leveraging Educational Data Mining for Real-time Performance Assessment of Scientific Inquiry Skills within Microworlds (2012)

We present Science Assistments, an interactive environment, which assesses students' inquiry skills as they engage in inquiry using science microworlds. We frame our variables, tasks, assessments, and methods of analyzing data in terms of evidence-centered design. Specifically, we focus on the student model, the task model, and the evidence model in the conceptual assessment framework. In order to support both assessment and the provision of scaffolding, the environment makes inferences about student inquiry skills using models developed through a combination of text replay tagging [cf. Sao Pedro et al. 2011], a method for rapid manual coding of student log files, and educational data mining. Models were developed for multiple inquiry skills, with particular focus on detecting if students are testing their articulated hypotheses, and if they are designing controlled experiments. Student-level cross-validation was applied to validate that this approach can automatically and accurately identify these inquiry skills for new students. The resulting detectors also can be applied at run-time to drive scaffolding intervention.
A Dynamic RFID-Based Mobile Monitoring System in Animal Care Management Over a Wireless Network (2007)

Due to the increasing integration of animals into family lifestyles, animal care management becomes an important issue as animals have a direct impact on human psychological and physical health. Even though there are a lot of solutions, maltreatment of animals and risks in animal health are increasing as indicated in the newspapers and statistics. In addition, many identification methods are not efficient and user-friendly. In this paper, an RFID-based mobile monitoring system (RFID-MMS) is designed in helping users to better manage the animals in dynamic information retrieving, location tracking, and behavior analyzing over a wireless network. The proposed system, which is suitable for using in all animals unities, enhances the companionship between humans and animals.
Cloning and overexpression of the Rhodobacter capsulatus hemH gene (1995)

In photosynthetically grown Rhodobacter capsulatus, heme is a qualitatively minor end product of the common tetrapyrrole pathway, but it may play a significant regulatory role. Heme is synthesized from protoporphyrin by the product of the hemH gene, ferrochelatase. We have cloned the R. capsulatus hemH gene by complementation of an Escherichia coli hemH mutant. When a plasmid carrying the hemH gene is returned to R. capsulatus, ferrochelatase activity increases, aminolevulinate synthase activity decreases, and bacteriochlorophyll levels are dramatically lowered. This is the first in vivo evidence to suggest that heme feedback inhibits aminolevulinate synthase in R. capsulatus, thereby reducing porphyrin synthesis.
Immunopathogenesis of infection in SPF chicks and commercial broiler chickens of a variant infectious bronchitis virus of economic importance (1996)

The immunopathogenesis of an economically important variant of infectious bronchitis virus (IBV) has been studied in day-old specific pathogen-free and 6-week-old broiler chickens. Experimental infection caused very mild respiratory disease and no mortalities. Diarrhoea was seen in the broilers. Virus distribution and titre in respiratory, urinary and enteric tissues were assessed. In SPF chicks, maximum virus isolations were from oesophagus, followed by trachea, kidney, lung and rectum. In contrast, in the broilers, maximum isolations were from ileum, followed by caecal tonsils, rectum, bursa of Fabricius and harderian gland, but virus was recovered less frequently from trachea, lung and kidney. In both groups virus replication was demonstrated in the epithelium of the trachea, kidneys and tissues of the lower gut by immunofluorescence. Immunostaining for CD4 and CD8 T-cell subsets in trachea, lung and kidney showed earlier and increased recruitment of CD8 cells over CD4 cells. From the kidneys of SPF chicks, no virus was isolated on days 10 or 14 p.i., but was recovered to high titre on day 21. Immunostaining showed the presence of IgM deposits in the glomeruli on those days when virus could not be recovered. In the broilers, gross muscle changes were produced which were less severe than reported in the field and without histopathological changes or increased creatine kinase levels in serum. There was no evidence of virus-induced immunosuppression. The spread of infection and rate of seroconversion to this IBV were similar to other IBV strains. The possible pathogenesis of the muscle changes is discussed.
Production of new‐to‐nature sophorolipids by cultivating the yeast <i>Candida bombicola</i> on unconventional hydrophobic substrates (2010)

The naturally occurring sophorolipids synthesized by Candida bombicola possess--despite their overall heterogeneity--little variation in the length of the lipid tail. The range is limited to C16-C18 fatty acids and is governed by the specificity of a cytochrome P450 monooxygenase. However, incorporation of fatty acids differing from the conventional C16-C18 range could broaden up the application potential of sophorolipids. The incorporation of medium-chain fatty acids should render the molecules more hydrophilic and consequently improve their water solubility. Two strategies to circumvent this C16-C18 preference are described in this paper. The first one skips the controlling action of the cytochrome P450 enzyme by supplying the yeast with already hydroxylated substrates, while the other method is based on the deception of the enzyme by presenting it substrates structurally resembling stearic acid. This later strategy can be applied to create very specific tailor-made sophorolipids when combined with post-fermentive modification.
H<sub>2</sub>‐Antihistaminika, 18. Mitt. 5,6‐Alkylsubstituierte 4‐Pyrimidinone mit H<sub>2</sub>‐antihistaminischer Wirkung (1984)

Abstract 5,6‐Alkylsubstituierte 2‐{2‐[(5‐Methyl‐4‐imidazolyl)‐methylthio]‐ethylamino}‐4‐pyrimidinone wurden dargestellt und auf ihre H 2 ‐antihistaminische Wirksamkeit untersucht.
Dermatofibrosarcoma Protuberans: The Current State of Multidisciplinary Management. (2020)

Dermatofibrosarcoma protuberans (DFSP) is a rare, infiltrative, soft tissue tumor. It has a propensity for deep invasion but a low risk for distant metastasis. The classic presentation is a slowly progressive, painless, and erythematous to purpuric patch on the trunk or arms. A deep, subcutaneous punch biopsy or incisional biopsy should be performed for diagnosis in all suspected cases; wide undermining of the skin is to be avoided for minimizing the risk of tumor seeding and for retaining the feasibility of histopathologic examination of re-excisions. Histopathologic distinction of DFSP from dermatofibroma requires immunohistochemical assessment for CD34, factor XIIIa, nestin, apolipoprotein D, and cathepsin K. Management of this cutaneous sarcoma involves a multidisciplinary oncologic approach. Surgical excision is usually the first step in management. DFSP has a high propensity for local recurrence, even when surgical margins are negative; therefore, radiation therapy or rarely systemic therapy is recommended, especially for locally advanced or metastatic cases. The indolent nature of DFSP requires lifelong surveillance for recurrence; however, most recurrences occur within 3 years of the primary excision. The median time for the development of a local recurrence is estimated to be 32 months. An emerging theragnostic transmembrane receptor target, folate hydrolase-1 (FOLH1; prostate-specific membrane antigen), has been expressed in benign dermatofibromas and in high-grade sarcomatous phenotypes. These findings suggest that DFSP may also express FOLH1, which could allow for surveillance with FOLH1 PET/CT and antibody-mediated brachytherapy.
Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart (2009)

Myocardial Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibition improves cardiac function following myocardial infarction (MI), but the CaMKII-dependent pathways that participate in myocardial stress responses are incompletely understood. To address this issue, we sought to determine the transcriptional consequences of myocardial CaMKII inhibition after MI. We performed gene expression profiling in mouse hearts with cardiomyocyte-delimited transgenic expression of either a CaMKII inhibitory peptide (AC3-I) or a scrambled control peptide (AC3-C) following MI. Of the 8,600 mRNAs examined, 156 were substantially modulated by MI, and nearly half of these showed markedly altered responses to MI with CaMKII inhibition. CaMKII inhibition substantially reduced the MI-triggered upregulation of a constellation of proinflammatory genes. We studied 1 of these proinflammatory genes, complement factor B (Cfb), in detail, because complement proteins secreted by cells other than cardiomyocytes can induce sarcolemmal injury during MI. CFB protein expression in cardiomyocytes was triggered by CaMKII activation of the NF-kappaB pathway during both MI and exposure to bacterial endotoxin. CaMKII inhibition suppressed NF-kappaB activity in vitro and in vivo and reduced Cfb expression and sarcolemmal injury. The Cfb-/- mice were partially protected from the adverse consequences of MI. Our findings demonstrate what we believe is a novel target for CaMKII in myocardial injury and suggest that CaMKII is broadly important for the genetic effects of MI in cardiomyocytes.