gebhart/patrepeval huggingface dataset:
On-chip jitter measurement architecture using a delay-locked loop with vernier delay line, to the order of giga hertz (2011)

In this paper, we present an enhanced architecture circuit design for embedded jitter measurement using the Vernier delay method with a single delay locked loop (DLL) structure, which characterizes the jitter in the order of picoseconds. The jitter measurement is realized by two delay chains feeding into the clock and data lines of a series of detector components known as a Vernier delay line (VDL). The matching of various delay elements is adjusted on-the-fly by an enhanced structure of a DLL feedback topology. Thereby, reducing the effect of the intrinsic gate delay variations due to process, voltage, temperature (PVT) changes; a limitation that reflects a major drawback of the VDL structure, and requires a large cost of design layout complexity. The nature of the design topology uses a small silicon area with a scalable jitter analyzer circuitry, which is used to collect the jitter on the data signal. The design nature is synthesizable using the field-programmable gate-array (FPGA) implementation. The proposed design estimates a silicon area of 0.074mm2, and HSPICE simulation results indicate a timing resolution of25ps in a 0.18µm TSMC CMOS process.
COLLISION WARNING AND AVOIDANCE SYSTEM FOR CREST VERTICAL CURVES (1998)

In recent years, State Road Route 114 which is located in Montgomery County, Virginia, has gained a bad reputation because of numerous traffic accidents. Most of these accidents resulted in loss of lives and property. Although there are many suggestions and proposals designed to prevent these accidents, to date no actions is taken yet. The focus of this research is to explore a technology-based, low cost solution that will lower or eliminate the risk of accidents on this two-lane rural highway.
Keratitis from Misuse of Corneal Anesthetics (1968)

Five cases are presented to emphasize the fact that chronic use of topical anesthetics on the eye can lead to severe keratitis and even permanent reduction of visual acuity. These reactions can be evoked in any eye that has been subjected to prolonged topical anesthesia as a means of relieving the discomfort of minor injuries. Loss of corneal epithelium (with resultant increased reliance on the anesthetic), opacification and edema of the corneal stroma and marked inflammatory changes in the anterior segment of the eye is the sequence of events that follow days or weeks of such treatment. Topical anesthetics should only be used for the purpose of obtaining transient loss of corneal sensitivity and never as part of a prolonged medical regimen.
The Molecular Biology of Rabies Viruses (1988)

Comparative nucleotide and deduced amino acid sequence analyses of the RNA and proteins of several fixed rabies virus strains have allowed detailed characterization of structural-functional relations of individual virus components. Several unique features of rabies viruses have been deduced from the complete nucleotide sequences of four of the five genes and the four intergenic regions of the genome. The most extensively analyzed rabies virus gene has been that of the surface glycoprotein. Direct comparisons between the deduced amino acid sequences of glycoprotein variants have led to the location of specific sites on the glycoprotein that bind virus-neutralizing antibodies and to the identification of an epitope correlating with viral pathogenicity. Structural requirements for immunogenic activity within the glycoprotein have also been investigated. This article presents an overview of the molecular biology of rabies viruses and describes the current state of knowledge of immunobiologic characteristics of different rabies virus components.
<title>Field testing of a portable fiber optic chemical sensor</title> (1995)

Purus, Inc. is field testing a portable fiber optic chemical sensor for the semi-specific determination of ppb levels of trichloroethylene (TCE), carbon tetrachloride and chloroform in water, soil and gaseous samples. The sensor consists of a flow optrode, proprietary reagent delivery and recovery system, fiber optic transmitter-receiver, embedded micro controller, display, and communication port. The reagents react with gaseous halogenated compounds that diffuse in through a gas permeable membrane to form a colored product, and the product is detected by its absorbance of light from a 560 nm light emitting diode. The analysis time is about 3 minutes at the detection limit of a few (mu) g/L in water and may be shortened at higher concentrations and further refinements to the hardware. Field trial results are presented for a site undergoing ground water remediation for trichloroethylene. Influent water streams containing > 100 ppm TCE, effluent water streams containing < 20 ppb TCE may be routinely monitored with high precision and accuracy. These results demonstrate the viability of using this fiber optic chemical sensor as an effective low cost screening tool for assessment, monitoring, and process control applications.
Wound Dressings Based on Chitosans and Hyaluronic Acid for the Release of Chlorhexidine Diacetate in Skin Ulcer Therapy (2007)

In the present work wound dressings, based on chitosan hydrochloride (HCS), 5-methyl-pyrrolidinone chitosan (MPC), and their mixtures with an anionic polymer, hyaluronic acid (HA), were prepared by freeze-drying. Chlorhexidine diacetate (CX) was used as an antimicrobic drug. The mechanical properties of the wound dressings were investigated. In particular, the wound dressings were subjected to dynamic hydration measurements to evaluate their capability to absorb wound exudate and to rheological analysis to investigate their resistance to mechanical stresses on hydration. The wound dressings were also characterized for drug release properties. The antioxidant and antimicrobial activities of medicated and non-medicated wound dressings were also investigated. All the wound dressings are characterized by mechanical resistance suitable for skin application. The addition of hyaluronic acid to chitosans leads to a reduction in wound dressing hydration properties and a modulation of drug release. The wound dressing based on MPC is characterized by the highest elastic properties and by the best scavenger activity. Antimicrobial activity against bacteria and C. albicans is shown by the dressing based on chitosan also in absence of chlorhexidine.
A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant (2012)

The innate immune system is responsible for recognizing invading pathogens and initiating a protective response. In particular, the retinoic acid-inducible gene 1 protein (RIG-I) participates in the recognition of single- and double-stranded RNA viruses. RIG-I activation leads to the production of an appropriate cytokine and chemokine cocktail that stimulates an antiviral state and drives the adaptive immune system toward an efficient and specific response against the ongoing infection. One of the best-characterized natural RIG-I agonists is the defective interfering (DI) RNA produced by Sendai virus strain Cantell. This 546-nucleotide RNA is a well-known activator of the innate immune system and an extremely potent inducer of type I interferon. We designed an in vitro-transcribed RNA that retains the type I interferon stimulatory properties, and the RIG-I affinity of the Sendai virus produced DI RNA both in vitro and in vivo. This in vitro-synthesized RNA is capable of enhancing the production of anti-influenza virus hemagglutinin (HA)-specific IgG after intramuscular or intranasal coadministration with inactivated H1N1 2009 pandemic vaccine. Furthermore, our adjuvant is equally effective at increasing the efficiency of an influenza A/Puerto Rico/8/34 virus inactivated vaccine as a poly(I·C)- or a squalene-based adjuvant. Our in vitro-transcribed DI RNA represents an excellent tool for the study of RIG-I agonists as vaccine adjuvants and a starting point in the development of such a vaccine.
Interference by cyanide with the measurements of papain hydrolysis (1969)

Abstract Potassium cyanide, a commonly used activator for the proteolytic enzyme papain, may be bound by the Strecker reaction to form cyanohydrins in digestion mixtures. The formation of these N‐containing complexes depends on the pH of the digest, incubation time and temperature, and the amount of reducing sugar present. They are soluble in 5% trichloroacetic acid (TCA), so the N in the complexes will be estimated together with the non‐protein N released during digestion. Their formation probably accounts for some experimental discrepancies observed when studying the action of KCN‐activated papain on extracted leaf proteins, and calculating the percentage hydrolysis from the amount of N found in the TCA‐soluble fraction. A procedure for digesting leaf proteins by papain is described that uses thioglycollic acid as activator, and the N is estimated in the undissolved substrate and the TCA‐precipitable fraction, instead of in the TCA‐soluble fraction.
Four- vs. five-coordination of nickel(II) with certain tertiary phosphorus ligands (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFour- vs. five-coordination of nickel(II) with certain tertiary phosphorus ligandsE. J. Lukosius and K. J. CoskranCite this: Inorg. Chem. 1975, 14, 8, 1922–1926Publication Date (Print):August 1, 1975Publication History Published online1 May 2002Published inissue 1 August 1975https://pubs.acs.org/doi/10.1021/ic50150a037https://doi.org/10.1021/ic50150a037research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Single‐Channel Techniques for Information Extraction from the Surface EMG Signal (2004)

This chapter contains sections titled: Introduction Spectral Estimation of Deterministic Signals and Stochastic Processes Basic Surface EMG Signal Models Surface EMG Amplitude Estimation Extraction of Information in Frequency Domain from Surface EMG Signals Joint Analysis of EMG Spectrum and Amplitude (JASA) Recurrence Quantification Analysis of Surface EMG Signals Conclusions References
Effet de la musculation sur la performance motrice spécifique aux tests de vitesse et de détente chez les jeunes (2015)

تعتبر التقوية العضلية أحد وسائل التدريب الرياضي التي تؤثر بشكل ايجابي على نتيجة الأداء الحركي الرياضي، و هذا من خلال تحسين مستوى التوافق العصبى-العضلى و التأثير على البنية العضلية. هذا البحث يسعى إلى دراسة تأثير التقوية العضلية علي نتيجة الأداء في اختبار السرعة و الوثب العمودي. 60 رياضيا اقل من 14 سنة شاركوا في هذه الدراسة (30 لاعب كرة القدم مقسمين إلي مجموعة تجريبية و ضابطة كلهما متشكلة من 15 فردا؛20 لاعب كرة اليد مقسمين إلي مجموعة تجريبية وضابطة كلهما متشكلة من 10 فردا؛18 لاعب كرة السلة مقسمين إلي مجموعة تجريبية و ضابطة كلهما متشكلة من 09 فردا). بينت (...)
A low-cost paper-based platform for fast and reliable screening of cellular interactions with materials (2020)

A paper-based platform was developed and tested for studies on basic cell culture, material biocompatibility, and activity of pharmaceuticals in order to provide a reliable, robust and low-cost cell study platform. It is based upon a paper or paperboard support, with a nanostructured latex coating to provide an enhanced cell growth and sufficient barrier properties. Wetting is limited to regions of interest using a flexographically printed hydrophobic polydimethylsiloxane layer with circular non-print areas. The nanostructured coating can be substituted for another coating of interest, or the regions of interest functionalized with a material to be studied. The platform is fully up-scalable, being produced with roll-to-roll rod coating, flexographic and inkjet printing methods. Results show that the platform efficiency is comparable to multi-well plates in colorimetric assays in three separate studies: a cell culture study, a biocompatibility study, and a drug screening study. The color intensity is quantified by using a common office scanner or an imaging device and the data is analyzed by a custom computer software without the need for expensive screening or analysis equipment.
The effects of the novel anti-anginal agent RS 43285 on [lactic acid], [K+] and pH in a canine model of transient myocardial ischaemia (1987)

Conference Article| December 01 1987 The effects of the novel anti-anginal agent RS 43285 on [lactic acid], [K+] and pH in a canine model of transient myocardial ischaemia MAXINE C. ALLELY; MAXINE C. ALLELY 1Syntex Research Centre, Riccarton, Edinburgh, EH14 4AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar BRIAN J. ALPS; BRIAN J. ALPS 1Syntex Research Centre, Riccarton, Edinburgh, EH14 4AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar ANDREW T. KILPATRICK ANDREW T. KILPATRICK 1Syntex Research Centre, Riccarton, Edinburgh, EH14 4AS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (6): 1057–1058. https://doi.org/10.1042/bst0151057 Article history Received: March 13 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation MAXINE C. ALLELY, BRIAN J. ALPS, ANDREW T. KILPATRICK; The effects of the novel anti-anginal agent RS 43285 on [lactic acid], [K+] and pH in a canine model of transient myocardial ischaemia. Biochem Soc Trans 1 December 1987; 15 (6): 1057–1058. doi: https://doi.org/10.1042/bst0151057 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: TMI, transient myocardial ischaemia, LAD, left anterior descending coronary artery, LV, left venticle, NEFA, non-esterified free fatty acids This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.
A 1.8-GHz 2-Watt Fully Integrated CMOS Push-Pull Parallel-Combined Power Amplifier Design (2007)

This paper newly presents a push-pull parallel-combined CMOS power amplifier (PA) and its analysis of operation. The proposed class-E CMOS PA incorporates the push-pull parallel-combined power devices with the 1:1:2 (two single-turn primary windings and a two-turn secondary winding) step-up on-chip transformer. The PA is fully integrated in a standard 0.18- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">μ</i> m CMOS technology without any external balun or matching networks. The operation of the PA with a multi-turn on-chip transformer is substantially analyzed in order to optimize the device size and its structure. Experimental data demonstrates the output power of 2-watt and the power-added efficiency (PAE) of more than 30% with a 3.3-V of power supply at 1.8 GHz. This is the new demonstration of the compact fully integrated CMOS PA with 2-watt of output power with very stable operation at 1.8GHz range.
Purification and characterization of CMP-<i>N</i>-acetylneuraminic acid hydroxylase from pig submandibular glands (1994)

N-Glycoloylneuraminic acid (Neu5Gc) is synthesized as its CMP-glycoside by the action of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase. This enzyme is a soluble cytochrome b5-dependent monooxygenase and has been purified to apparent homogeneity from pig submandibular glands by precipitation with N-cetyl-N,N,N-trimethylammonium bromide and fractionation on Q-Sepharose, Cibacron Blue 3GA-Agarose, Reactive Brown 10-Agarose, Hexyl-Agarose and Superose S.12. This procedure resulted in an 8960-fold purification of the hydroxylase with a recovery of 0.8%. The molecular mass of this protein was shown to be 65 kDa on SDS-PAGE and approximately 60 kDa as determined by gel filtration on Superose S.12, which suggests that the enzyme is a monomer. The purified CMP-Neu5Ac hydroxylase is activated by FeSO4 and inhibited by iron-binding reagents such as o-phenanthroline, KCN, Tiron and ferrozine. An apparent Km of 11 microM was determined for the substrate CMP-Neu5Ac using purified hydroxylase in the presence of Triton X-100-solubilized microsomes. In a reconstituted system consisting of purified hydroxylase, cytochrome b5, cytochrome b5 reductase and catalase, an apparent Km of 3 microM was measured. The apparent Km for cytochrome b5 in this system was 0.24 microM. Immunization of a rabbit with enriched and purified hydroxylase led to an antiserum that inhibited CMP-Neu5Ac hydroxylase activity and reacted with the purified 65 kDa protein on a Western blot after SDS-PAGE. Antibodies specific for this 65 kDa protein were isolated and showed a strong reaction with the purified CMP-Neu5Ac hydroxylase from mouse liver after immunoblotting.(ABSTRACT TRUNCATED AT 250 WORDS)
Optimization of the Azobenzene Scaffold for Reductive Cleavage by Dithionite; Development of an Azobenzene Cleavable Linker for Proteomic Applications (2010)

Abstract In this paper we conducted an extensive reactivity study to determine the key structural features that favour the dithionite‐triggered reductive cleavage of the azo–arene group. Our stepwise investigation allowed identification of a highly reactive azo–arene structure 25 bearing a carboxylic acid at the ortho position of the electron‐poor arene and an ortho ‐ O ‐alkyl‐resorcinol as the electron‐rich arene. Based on this 2‐(2′‐alkoxy‐4′‐hydroxyphenylazo)benzoic acid (HAZA) scaffold, the orthogonally protected difunctional azo–arene cleavable linker 26 was designed and synthesized. Selective linker deprotection and derivatization was performed by introducing an alkyne reactive group and a biotin affinity tag. This optimized azo–arene cleavable linker led to a total cleavage in less than 10 s with only 1 m M dithionite. Similar results were obtained in biological media.
Resource usage policy expression and enforcement in grid computing (2007)

To date, not enough attention has been paid to issues surrounding the description and enforcement of policies for controlling grid resources. These policies define the permitted or desired usage scenario(s) allowed by resource providers, virtual organizations, or even the governing body for an entire grid. Most existing Grid systems have either "in-spirit" usage policies with no actual enforcement (e.g., all resource providers are assumed to contribute in kind), or have implicit resource usage policies whose intent can only be manifested by examining the ad-hoc policy enforcement. Moreover, systems that do define some resource usage policies typically consider only CPU resources, without mentioning other grid resources such as disk and bandwidth. Unless sufficient resource usage policies and enforcement mechanisms are created, resource providers will be increasingly reluctant to participate in grids out of fear that their local resources will be overrun. In this paper, we identify the requirements for a resource usage policy language, and then propose an event-centric model by which to implement these policies. We describe the language structure, its implementation on top of the XML access control language XACML and a policy service that processes the language. Because decisions based on this type of policy typically require information from outside the security context of a single grid request, we extend XACML for general timer-based and event-centric processing necessary to enforce such Grid resource usage policies. We evaluate our prototype implementation on a grid consisting of three data repositories by showing that a usage policy-controlled grid environment can be achieved with only minimal overhead.
Anticonvulsant effect of FS‐1 subfraction isolated from roots of<i> Delphinim denudatum</i> on hippocampal pyramidal neurons (2003)

The effects were investigated of a partially purified subfraction (FS-1) isolated from Delphinium denudatum on sustained repetitive firing (SRF) of cultured neonatal rat hippocampal pyramidal neurons. The blockade of sustained repetitive firing is one of the basic mechanisms of antiepileptic drugs at the cellular level. Using the whole cell current-clamp technique, sustained repetitive firing was elicited in pyramidal neurons under study by a depolarizing pulse of 500 ms duration, 0.3 Hz and 0.1-0.6 nA current strength. FS-1 (0.01-0.06 mg/mL) reduced the number of action potentials per pulse in a dose-dependent manner until no action potentials were elicited for the remainder of the pulse. There was a corresponding use-dependent reduction in amplitude and Vmax of action potentials. The Vmax of action potential 1 exhibited a dose-dependent reduction. At a dose of 0.06 mg/mL FS-1 reduced Vmax to 29%-38% and amplitude to 16%-20 % of the control values. The blockade of sustained repetitive firing by FS-1 was reversed by hyperpolarization of the membrane potential (-65 to -75 mV) while depolarization of the membrane potential (-53 mV to -48 mV) potentiated the block. The results suggest that FS-1 blocks sustained repetitive firing in hippocampal neurons in a use-dependent and voltage-dependent manner similar to the prototype anticonvulsant drug, phenytoin. However, unlike phenytoin, which binds preferably to the inactive state, the compounds present in FS-1 also interacted with the resting state of the Na+ channels by reducing Vmax of action potential 1. The results indicate that the partially purified FS-1 subfraction of Delphinium denudatum contains a potent anticonvulsant compound.
EFFECT OF BASIC FIBROBLAST GROWTH FACTOR INCORPORATING GELATIN MICROSPHERES ON ERECTILE FUNCTION IN THE DIABETIC RAT (2005)

We report the maintenance of erectile function with bFGF incorporating gelatin microspheres in diabetic rats. The rationale of this maneuver is smooth muscle preservation by the long-term release of bFGF. This is a novel therapeutic option that is clinically applicable for diabetes induced erectile dysfunction.
Ultrafast High-pressure AC Electro-osmotic Pumps for Portable Biomedical Microfluidics (2009)

This paper details the development of an integrated AC electro-osmotic (ACEO) microfluidic pump for dilute electrolytes consisting of a long serpentine microchannel lined with three dimensional (3D) stepped electrode arrays. Using low AC voltage (1 Volt rms, 1 kHz), power (5 mW) and current (3.5 mA) in water, the pump is capable of generating a 1.4 kPa head pressure, a 100-fold increase over prior ACEO pumps, and a 1.37 mm/sec effective slip velocity over the electrodes without flow reversal. The integrated ACEO pump can utilize low ionic strength solutions such as distilled water as the working solution to pump physiological strength (100 mM) biological solutions in separate microfluidic devices, with potential applications in portable or implantable biomedical microfluidic devices. As a proof-of-concept experiment, the use of the ACEO pumps for DNA hybridization in a microfluidic microarray is demonstrated.