gebhart/patrepeval huggingface dataset:
Brain endorphin levels increase after long-term chlorpromazine treatment (1979)

Observations in animals (Bloom et al., 1976; Jacquet and Marks, 1976) and man (Terenius et al., 1976; Gunne et al., 1977; Kline et al., in press) suggest the possible involvement of brain endorphins in mental illness. Terenius et al. (1976) reported that four chronic schizophrenics exhibited elevated levels of endorphins in their cerebrospinal fluid during ‘a symptom-rich’ phase of their disease. In two of these patients, whose condition improved during neuroleptic therapy, there was a return to low endorphin level (Gunne et al., 1977). These findings are consistent with the idea that some psychotic symptoms might be caused by excessive endorphin activity. We report here raised endorphin levels in brains of rats after long-term administration of the antipsychotic agent chlorpromazine (CPZ), but not after the structurally-related antidepressant imipramine. This raises the possibility that the therapeutic action of antipsychotics may be associated with changes in endorphin activity.
Hybrid Full-Bridge Three-Level LLC Resonant Converter—A Novel DC–DC Converter Suitable for Fuel-Cell Power System (2006)

This paper proposes a novel hybrid full-bridge (H-FB) three-level (TL) LLC resonant converter. It integrates the advantages of the H-FB TL converter and the LLC resonant converter. It can operate under both three-level mode and two-level mode, so it is very suitable for wide-input-voltage-range applications, such as fuel-cell power systems. Compared with the traditional full-bridge converter, the input current ripple and output filter can be reduced. In addition, all the switches can realize zero-voltage switching from nearly zero to full load, and the switches of the TL leg sustain only half of the input voltage. Moreover, the rectifier diodes can achieve zero-current switching, and the voltage stress across them can be minimized to the output voltage. A prototype of 200-400-V input and 360-V/4-A output is built in our laboratory to verify the operation principle of the proposed converter
Site-Specific Drug Delivery by Photochemical Internalization Enhances the Antitumor Effect of Bleomycin (2005)

AlPcS2a-based photochemical internalization of bleomycin induces a synergistic inhibition of tumor growth in three different tumor models. This treatment combination should be further considered for clinical utilization.
Homology-based gene structure prediction: simplified matching algorithm using a translated codon (tron) and improved accuracy by allowing for long gaps (2000)

gotoh@cancer-c.pref.saitama.jp
Directed enzyme evolution : screening and selection methods (2003)

Directed evolution, the application of evolutionary design to enzyme engineering, requires effective screening strategies to isolate those proteins that perform a desired function from the libraries generated by the techniques. In Directed Enzyme Evolution: Screening and Selection Methods, seasoned practitioners from many leading laboratories describe their leading and readily reproducible screening strategies for isolating useful clones. These techniques have been optimized for sensitivity, high throughput, and robustness, and are of proven utility for directed evolution purposes. The assays presented use a variety of techniques, including genetic complementation, microtiter plates, solid-phase screens with colorimetric substrates, and flow cytometric screens. There are also representative examples of how phage libraries may be interrogated for enzymatic activity. Each protocol contains detailed step-by-step instructions and many notes on how best to deal with the problems that may occur. An accompanying volume, Directed Evolution Library Creation: Methods and Protocols (ISBN 1-58829-285-1), describes readily reproducible methods for the creation of mutated DNA molecules and DNA libraries. Taken together, Directed Enzyme Evolution: Screening and Selection Methods and Directed Evolution Library Creation: Methods and Protocols capture for newcomers and more experienced investigators alike all the key methods for using directed protein evolution to better understand protein structure-function relationships, to discover new enzymes and therapeutic proteins, and to design new assays suitable for specific applications
Recovering and Protecting against DNS Cache Poisoning Attacks (2011)

DNSSEC can provide a strong countermeasure to DNS Cache Poisoning Attacks, however, DNSSEC can't be actually deployed in a short time, it is still impossible to avoid poisoning attacks thoroughly, a majority of DNS servers are still hreatened from the poisoning attacks. This attack is used in conjunction with web spoofing, it can change Web URL, lead economic losing and privacy leaking. In this paper, we emphasize on the recovery and protection after suffered DNS Cache Poisoning Attacks. We expect to decrease success ratio of poisoning attacks greatly through restoration, source port randomization (SPR) and setting time-to-live (TTL). After above deployments, attackers have to extend attack time to make attack successful, and this will provide sufficient time to defend and preserve. The strategy of this paper greatly increases resistance of DNS server against DNS poisoning, and also can be a transition before DNSSEC is deployed thoroughly.
High sensitivity magnetic field sensor using GMR materials with integrated electronics (2002)

This paper presents the first commercially available IC that integrates Giant Magnetoresistive Ratio (GMR) materials with semiconductor devices. This marriage results in a highly sensitive, inexpensive, low power, and temperature stable magnetic field sensor. The chip uses a BiCMOS 1.5 /spl mu/ process and a masterslice design approach that allows rapid prototyping of many custom configurations in a 35 mil by 95 mil size. Sensing of a wide range of magnetic fields (0-500 Gauss) is possible, with digital and linear outputs available. Temperature range of operation is -55 C to +150 C making the chip ideal for many automotive, industrial, and military applications.
Architectural styles for runtime software adaptation (2009)

Runtime software adaptability - the ability to change an application's behavior during runtime - is an increasingly important capability for systems, both to support continuous operation and to support a good user experience. Achieving such adaptability may be very hard or easy; the degree of difficulty will largely reflect choices made in a system's architecture. Some architectural styles are much more supportive of dynamic change than others. This paper examines a range of styles and assesses them with respect to a four-element evaluation framework, called BASE. The framework considers how a style supports changes to behavior, state, its execution context, and supports asynchrony of change. Styles considered include REST, event-based, service-oriented, and peer-to-peer.
Membrane biological reactor system for treatment of oily wastewaters (1994)

ABSTRACT: The membrane biological reactor (MBR) system consists of a suspended‐growth biological reactor combined with a membrane ultrafiltration unit process. It is particularly attractive in situations where long solids retention times are required, and physical retention and subsequent hydrolysis are critical to achieving biological degradation of pollutants. In order to develop full scale process design information, a large pilot system was operated for eleven months. The pilot project involved assessing performance and developing design information for the system in the treatment of wastewater from two General Motors (GM) facilities. The pilot system results provided a basis for design of a full scale, demonstration MBR system for treatment of industrial wastewater. Case history information is presented in this paper on the design of the MBR system and subsequent operation and performance. Despite certain design issues, the system has met or exceeded performance expectations.
A NOTE ON THE ECOLOGY OF<u>ATRACTASPIS BIBRONII</u> (1963)

(1963). A NOTE ON THE ECOLOGY OF ATRACTASPIS BIBRONII. Journal of the Herpetological Association of Rhodesia: Vol. 21, No. 1, pp. 5-5.
Separator Membrane from Crosslinked Poly(Vinyl Alcohol) and Poly(Methyl Vinyl Ether-alt-Maleic Anhydride) (2015)

In this work, we report separator membranes from crosslinking of two polymers, such as poly vinyl alcohol (PVA) with an ionic polymer poly(methyl vinyl ether-alt-maleic anhydride) (PMVE-MA). Such interpolymer-networked systems were extensively used for biomedical and desalination applications but they were not examined for their potential use as membranes or separators for batteries. Therefore, the chemical interactions between these two polymers and the influence of such crosslinking on physicochemical properties of the membrane are systematically investigated through rheology and by critical gel point study. The hydrogen bonding and the chemical interaction between PMVE-MA and PVA resulted in highly cross-linked membranes. Effect of the molecular weight of PVA on the membrane properties was also examined. The developed membranes were extensively characterized by studying their physicochemical properties (water uptake, swelling ratio, and conductivity), thermal and electrochemical properties using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermo-gravimetric analysis (TGA) and electrochemical impedance spectroscopy (EIS). The DSC study shows the presence of a single <i>T</i><sub>g</sub> in the membranes indicating compatibility of the two polymers in flexible and transparent films. The membranes show good stability and ion conductivity suitable for separator applications.
Laser treatment of premalignant and malignant squamous cell lesions of the penis (1992)

Thirty men with biopsy-proven premalignant or malignant squamous cell lesions of the penis were treated. All had subclinical aceto-white lesions with histologic evidence for human papilloma virus infection. Nineteen patients had penile intraepithelial neoplasia (PIN I and II) and 11 had squamous cell carcinoma. Of these 11 patients, 6 had noninvasive penile intraepithelial neoplasia--carcinoma in situ (PIN III/Tis)--and 5 had invasive squamous cell carcinoma (4 stage T2 and 1 T3). All were treated with laser: CO2 was used for low-stage lesions, Nd:YAG was used alone or in combination with CO2 laser for more histologically advanced lesions, and KTP/532 was used in one patient with squamous cell carcinoma (Tis). Follow-up in 23 patients for up to 2 years showed that all but 1 (stage T3) remained free from penile malignancy. Appropriate laser therapy for all but deeply invasive (T3) tumors controls local disease, producing results that are clinically equal and cosmetically and functionally far superior to partial penectomy.
Highly Conformal Ni Micromesh as a Current Collecting Front Electrode for Reduced Cost Si Solar Cell (2017)

Despite relatively high manufacturing cost, crystalline-Si solar cell continues to hold promising future due to its high energy conversion efficiency and long life. As regards cost, one pertinent issue is the top electrode metallization of textured cell surface, which typically involves screen printing of silver paste. The associated disadvantages call for alternative methods that can lower the cost without compromising the solar cell efficiency. In the present work, a highly interconnected one-dimensional (1D) metal wire network has been employed as front electrode on conventional Si wafers. Here, for the first time, we report an innovative solution based crackle templating method for conformal metal wire network patterning over large textured surfaces. Laser beam induced current mapping showed uniform photocurrent collection by the electrodes without any shadow losses. With electroless deposition of Ni wire network on corrugated solar cell, a short circuit current of 33.28 mA/cm<sup>2</sup> was obtained in comparison to 20.53 mA/cm<sup>2</sup> without the network electrode. On comparing the efficiency with the conventional cells with screen printed electrodes, a 20% increment in efficiency has been observed. Importantly, the estimated manufacturing cost is at least two orders lower.
Fatty acid synthesis by spinach chloroplasts II. The path from PGA to fatty acids (1975)

By incorporation of 3H2O into the fatty acid chain in the presence of unlabeled precursor, we showed that fatty acids are synthesized from PGA, PEP and pyruvate by intact spinach chloroplasts in the light. 13C-tracer experiments confirmed that 1-C of pyruvate is decarboxylated and 2-C is incorporated into fatty acids by the chloroplasts. The patterns of fatty acids synthesized from PGA and pyruvate were the same as that from acetate. The highest rate of fatty acid synthesis was reached at the physiological concentration of PGA (3 mM) and pyruvate (1 mM). These results indicate the operation of the following path in the chloroplasts in light: PGA→-PEP→Pyruvate→acetylCoA→fatty acids. Since citrate and OAA were much less active and malate and glyoxylate were inert as precursors for fatty acid synthesis, PEP or pyruvate carboxylation, citrate lyase reaction and malate synthetase reaction are not involved in the formation of acetylCoA and fatty acids. Since pyruvate was much more effective as a substrate for fatty acid synthesis than lactate, acetaldehyde or acetate, direct, decarboxylation path is considered to be the primary path from pyruvate to acetylCoA. The insignificant effect of chloroplast-washing on fatty acid synthesis from PGA and pyruvate indicates that the glycolytic path from PGA to pyruvate is associated with the chloroplasts. Since pyruvate was more effectively incorporated into fatty acids than acetylCoA, it is unlikely that pyruvate decarboxylation to acetylCoA is due to mitochondria contaminating the chloroplast preparation. On the basis of measurements of 3H2O incorporation in the light and dark, the activity of fatty acid synthesis in spinach leaves appears to be shared by the activities in chloroplasts (87%) and other organelles (13%).
Effects of pramipexole treatment on the α-synuclein content in serum exosomes of Parkinson's disease patients (2016)

Advances approaches in the treatment of Parkinson's disease are needed. The study was aimed to evaluate the therapeutic value of the new dopamine receptor agonist pramipexole. The effects of pramipexole on serum exosomes were investigated, and the possible mechanisms of action of the drug were explored. Initially, 68 patients were included in the study, of whom 3 cases did not complete the study. The remaining 65 patients were administered pramipexole at increasing doses starting at 0.25 mg twice a day for the 1st week, and reaching 1.5 mg three times daily at the 8th week. The doses were tapered during the course of the following 4 weeks. The total scores of the motor examination of the unified Parkinson's disease rating scale III (UPDRS III) and the total scores of the daily life activity in UPDRS II were compared before and after treatment. The relative expression amounts of α-synuclein in serum exosomes were then calculated by western blot analysis. Scores of UPDRS III and UPDRS II following treatment were significantly lower than the scores prior to treatment, and the difference was statistically significant (P<0.05). The relative expression of α-synuclein in serum exosomes was also found to be significantly lower after treatment (P<0.05). The relative expression of α-synuclein in the effective treatment group was significantly lower than that in the ineffective treatment group, and the difference was statistically significant (P<0.05). The relative expression of α-synuclein in serum exosomes was significantly correlated with treatment effects (P<0.05). In conclusion, pramipexole was effective and safe as a treatment for Parkinson's disease. The therapeutic effect of pramipexole may be associated with its reducing effect on the relative expression of α-synuclein in serum exosomes.
El Defoliador del Cipres, Glena bisulca Rindge 1972 - 73 (1974)

El presente trabajo recopila la experiencia adquirida por el autor con esta plaga desde abril de 1973, epoca en la cual se vinculo a la empresa Cipreses de Colombia S.A., mediante un contrato suscrito entre esta empresa y la Universidad Nacional, con el objetivo de hacerse cargo del control del insecto.

Las caracteristicas masivas de la plaga, la rapidez de sus danos, la carencia inicial de medios adecuados para su combate asi como de personas debidamente entrenado, no permitieron al autor realizar investigaciones con el caracter de tal. En su lugar se realizaron observaciones y estudio sencillos que a pesar de su simplicidad contribuyen a un conocimiento mas avanzado del insecto, su ecologia y su control.
Actualités de l’ASCO 2007 (2007)

Le compartiment primitif des cellules souches des LAL CD34CD19concernerait pour les hauts risques une cellule non lymphoide. Les cellules primitives chimioresistantes sont helas aussi insensibles a l’immunotherapie (Vormoor*). La genomique n’a pas modifie la classification pronostique, mais a decouvert des profils therapeutiques caracteristiques : de transformation des LALMLL+ sensibles aux anti-FLT3 et agents hypomethylants type capecitabine ou de resistance aux corticoides sensibles au sirolimus/rapamycin, inhibiteur de mTOR (Bhojwani*).
Identification of myocardial infarction (MI) using spatio-temporal heart dynamics (2011)

Cardiovascular disorders, such as myocardial infarction (MI) are the leading causes of mortality in the world. This paper presents an approach that uses novel spatio-temporal patterns of the vectorcardiogram (VCG) signals for the identification of various types of MI. In contrast to the traditional electrocardiogram (ECG) approaches, the 3D cardiac VCG signal is partitioned into 8 octants for localized analysis of the heart's electrical activities. The proposed method was tested using the PhysioNet PTB database for 368 MIs and 80 healthy control (HC) recordings, each of which includes 12-lead ECG and 3-lead VCG. Significant differences are found in the VCG spatial distribution between MI and HC groups. Furthermore, classification and regression tree (CART) analysis was used to demonstrate that VCG octant features can distinguish MIs from HCs with a sensitivity (accuracy of MI identification) of 97.28% and a specificity (accuracy of HC identification) of 95.00%, which is promising compared to the previously reported results using other ECG databases. The results indicate that the present approach provides an effective way for monitoring, post-processing, and interpretation of ECG data, and hopefully can impact the current cardiac diagnostic practice.
Greatly improved survival and neuroprotection in aquaporin‐4‐knockout mice following global cerebral ischemia (2013)

Aquaporin-4 (AQP4), the principal water channel in astrocytes, is involved in brain water movement, inflammation, and neuroexcitation. In this study, there was strong neuroprotection in mice lacking AQP4 in a model of global cerebral ischemia produced by transient, bilateral carotid artery occlusion (BCAO). Survival and neurological outcome were greatly improved in the AQP4(-/-) vs. AQP4(+/+) mice after occlusion, with large and robust differences in both outbred (CD1) and inbred (C57bl/6) mouse strains without or with mechanical ventilation. Improved survival was also seen in mice lacking the scaffold protein α-syntrophin, which manifest reduced astrocyte water permeability secondary to defective AQP4 plasma membrane targeting. Intracranial pressure elevation and brain water accumulation were much reduced in the AQP4(-/-) vs. AQP4(+/+) mice after carotid artery occlusion, as were blood-brain barrier (BBB) disruption and neuronal loss. Brain slices from AQP4(-/-) mice showed significantly reduced cell swelling and cytotoxicity in response to oxygen-glucose deprivation, compared with slices from AQP4(+/+) mice. Our findings suggest that the neuroprotective effect of AQP4 deletion in global cerebral ischemia involves reduced astrocyte swelling and brain water accumulation, resulting in reduced BBB disruption, inflammation, and neuron death. AQP4 water transport inhibition may improve survival and neurological outcome after cardiac arrest and in other conditions associated with global cerebral ischemia.
Method for breast cancer classification based solely on morphological descriptors (2004)

A decision support system has been developed to assist the radiologist during mammogram classification. In this paper, mass identification and segmentation methods are discussed in brief. Fuzzy region-growing techniques are applied to effectively segment the tumour candidate from surrounding breast tissue. Boundary extraction is implemented using a unit vector rotating about the mass core. The focus of this work is on the feature extraction and classification processes. Important information relating to the malignancy of a mass may be derived from its morphological properties. Mass shape and boundary roughness are primary features used in this research to discriminate between the two types of lesions. A subset from thirteen shape descriptors is input to a binary decision tree classifier that provides a final diagnosis of tumour malignancy. Features that combine to produce the most accurate result in distinguishing between malignant and benign lesions include: spiculation index, zero crossings, boundary roughness index and area-to-perimeter ratio. Using this method, a classification result of high sensitivity and specificity is achieved, with false-positive and falsenegative rates of 9.3% and 0% respectively.
Dworkin's Jurisprudence and 'Hospital Products': Principles, Policies and Fiduciary Duties (1988)

The imposition of fiduciary duties in commercial relationships raises difficult questions of equitable doctrine and of legal policy, which received the consideration of the High Court in Hospital Products Ltd v United States Surgical Corporation. The decision in Hospital Products illustrates the complexity of the judicial approach to hard cases, which MacCormick observes typically involve the complex interplay between considerations of principle, consequentialist arguments, and disputable points of interpretation of established valid rules.
Ulinastatin treatment for acute respiratory distress syndrome in China: a meta-analysis of randomized controlled trials (2019)

Ulinastatin seemly showed a beneficial effect for ARDS patients treatment and larger sample sized RCTs are needed to confirm our findings.
Electron Tunneling in Metal-Semiconductor Barriers (1966)

Tunneling through the space-charge region of a uniformly doped semiconductor has been calculated in the effective-mass approximation. The exact solutions of the one-dimensional Schr\"odinger equation for a parabolic potential are used to determine the transparency of the barrier. Numerical results are presented for parameters appropriate to indium and $n$-type germanium. An example of experimental results typical of this system is quoted to illustrate qualitative agreement.