gebhart/patrepeval huggingface dataset:
Effects of Diet on Blood Lipids In Man (1955)

Abstract 1. Lipids exist in the blood serum as emulsions ("chylomicrons") and as solutions of lipoprotein containing proteins, cholesterol, and other lipids. Interest in relation to atherosclerosis is centered on the cholesterol and the beta lipoproteins which contain most of the cholesterol. 2. The diet influences the blood lipids in man and animals but great quantitative differences between species makes it essential to study man himself to discover the effects of the diet on the blood lipids in man. 3. The amount of lipid in the chylomicron form in the serum is practically independent of the concentration of cholesterol and lipoproteins in the serum. The correlation between the concentrations of alpha and beta lipoproteins is very low. 4. Experiments on man show that dietary cholesterol per Se, even in large amount, has no important influence on the serum cholesterol concentration but that the latter is markedly affected by the total fat content of the diet. 5. Calorie intake per se has little influence on the blood lipids. Such effect as it has may be secondary to fat metabolism differences commonly associated with differences in calorie intakes. 6. Studies on population samples of healthy men show a marked direct relationship between the content or proportion of fat in the diet on the one hand and the concentration of total cholesterol and of beta lipoproteins in the serum on the other. The effect of the diet tends to be greater in middle-aged men than in younger men. 7. The average concentration of cholesterol in the serum of men in areas where the diets are very high in fats (of the order of 40 per cent of calories), is 25 to 50 per cent greater than the average in areas where the diets are low in fats (of the order of 20 per cent, or less, of calories). 8. A significant effect of dietary fat level on the serum cholesterol concentration is evident in man in a few weeks on a changed diet. The effect tends to increase very slowly with time thereafter and it is most pronounced when comparison is made between populations habitually subsisting on different diets. 9. It is not known how the dietary fat intake exerts its controlling influence on the blood lipids of man but the mechanisms must be complex.
Insecticide Resistance After <i>Silent Spring</i> (2012)

Combating insecticide resistance is a continual challenge for the preservation of both traditional and transgenic crops.
Removal of Acetic Acid by Adsorption from an Ethylene Recycle Stream in the Ethylene–Vinyl Acetate Copolymerization Process (1999)

The quality of EVA copolymers (ethylene and vinyl acetate copolymers) depends on the impurities in the feed. The removal of acetic acid, formed due to the partial degradation of the EVA copolymer, by adsorption from the recycle ethylene stream has been studied. Activated carbon proved to be useful for this purpose due to its high adsorption capacity and selectivity to acetic acid and its easy and complete regeneration. Adsorption isotherms and breakthrough curves of ethylene, acetic acid, and vinyl acetate, and binary acetic acid–vinyl acetate mixtures have been obtained at 293 K. Mass transfer and pore diffusion coefficients have been determined using two adsorption models. These data have allowed the design of an adsorption installation for the improvement of quality of EVA copolymer.
Formation of subwavelength periodic structures on tungsten induced by ultrashort laser pulses (2007)

The evolution of surface morphology of tungsten irradiated by single-beam femtosecond laser pulses is investigated. Ripplelike periodic structures have been observed. The period of these ripples does not show a simple relation to the wavelength and angle of incidence. The orientation of ripples is aligned perpendicularly to the direction of polarization for linearly polarized light. Surprisingly, we find that the alignment of the ripple structure turned left or right by 45 degrees with respect to the incident plane when using right and left circularly polarized light, respectively. The period of the ripple can be controlled by the pulse energy, the number of pulses, and the incident angle. We find a clear threshold for the formation as a function of pulse energy and number of pulses. The mechanism for the ripple formation is discussed, as well as potential applications in large-area structuring of metals.
Efficacy of topical ciprofloxacin in the treatment of ear infections in adults (1993)

Journal Article Efficacy of topical ciprofloxacin in the treatment of ear infections in adults Get access J. A. GARCÍA RODRÍGUEZ, J. A. GARCÍA RODRÍGUEZ aDepartment of Microbiology: Hospital Clinico UniversitarioSalamanca, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar J. E. GARCÍA SÁNCHEZ, J. E. GARCÍA SÁNCHEZ aDepartment of Microbiology: Hospital Clinico UniversitarioSalamanca, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar M. I. GARCÍA GARCÍA, M. I. GARCÍA GARCÍA aDepartment of Microbiology: Hospital Clinico UniversitarioSalamanca, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar E. GARCÍA SÁNCHEZ, E. GARCÍA SÁNCHEZ aDepartment of Microbiology: Hospital Clinico UniversitarioSalamanca, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. MUÑOZ BELLIDO, J. L. MUÑOZ BELLIDO aDepartment of Microbiology: Hospital Clinico UniversitarioSalamanca, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar A. RAMOS MACÍAS A. RAMOS MACÍAS bDepartment of E.N.T., Hospital Clinico UniversitarioSalamanca, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 31, Issue 3, March 1993, Pages 452–453, https://doi.org/10.1093/jac/31.3.452 Published: 01 March 1993
Selected Soybean Plant Introductions with Partial Resistance to <i>Sclerotinia sclerotiorum</i> (2002)

Sclerotinia stem rot, caused by Sclerotinia sclerotiorum, is a major soybean (Glycine max) disease in north-central regions of the United States and throughout the world. Current sources of resistance to Sclerotinia stem rot express partial resistance, and are limited in number within soybean germ plasm. A total of 6,520 maturity group (MG) 0 to IV plant introductions (PIs) were evaluated for Sclerotinia stem rot resistance in the United States and Canada in small plots or in the greenhouse from 1995 to 1997. Selected PIs with the most resistance were evaluated for resistance in the United States and Canada in replicated large plots from 1998 to 2000. The PIs in the MG I to III tests in Urbana, IL were evaluated for agronomic traits from 1998 to 2000. The selected PIs also were evaluated with an excised leaf inoculation and petiole inoculation technique. After the 1995 to 1997 evaluations, all but 68 PIs were eliminated because of their susceptibility to Sclerotinia stem rot. In field tests in Urbana, higher disease severity in selected MG I to III PIs was significantly (P< 0.05) associated with taller plant heights and greater canopy closure. All other agronomic traits evaluated were not associated or were inconsistently associated with disease severity. MG I to III PIs 153.282, 189.931, 196.157, 398.637, 417.201, 423.818, and 561.331 had high levels of resistance and had canopies similar to the resistant checks. The resistance ratings from the petiole inoculation technique had a high and significant (P< 0.01) correlation with disease severity in the MG I and II field tests. The partially resistant PIs identified in this study can be valuable in incorporating Sclerotinia stem rot resistance into elite germ plasm.
Mobile Monitoring of Air Pollution Reveals Spatial and Temporal Variation in an Urban Landscape (2021)

Urban air pollution poses a major threat to human health. Understanding where and when urban air pollutant concentrations peak is essential for effective air quality management and sustainable urban development. To this end, we implement a mobile monitoring methodology to determine the spatiotemporal distribution of particulate matter (PM) and black carbon (BC) throughout Philadelphia, Pennsylvania and use hot spot analysis and heatmaps to determine times and locations where pollutant concentrations are highest. Over the course of 12 days between June 27 and July 29, 2019, we measured air pollution concentrations continuously across two 150 mile (241.4 km) long routes. Average daily mean concentrations were 11.55 ± 5.34 μg/m 3 (PM 1 ), 13.48 ± 5.59 μg/m 3 (PM 2.5 ), 16.13 ± 5.80 μg/m 3 (PM 10 ), and 1.56 ± 0.39 μg/m 3 (BC). We find that fine PM size fractions (PM 2.5 ) constitute approximately 84% of PM 10 and that BC comprises 11.6% of observed PM 2.5 . Air pollution hotspots across three size fractions of PM (PM 1 , PM 2.5 , and PM 10 ) and BC had similar distributions throughout Philadelphia, but were most prevalent in the North Delaware, River Wards, and North planning districts. A plurality of detected hotspots found throughout the data collection period (30.19%) occurred between the hours of 8:00 AM–9:00 AM.
Cell surface expression and functional significance of adhesion molecules on human myeloma‐derived cell lines (1994)

Multiple myeloma is characterized by the presence of malignant plasma cells predominantly localized in bone marrow. Our prior studies have suggested that human myeloma derived-cell lines adhere specifically to fibronectin and to bone marrow stromal cells (BMSCs) via beta 1 and beta 2 integrins as well as RGD peptide, and that tumour cell to BMSC contact triggers interleukin-6 (IL-6) secretion from BMSCs. Since IL-6 is a growth factor for myeloma, adhesion may be important in paracrine IL-6 mediated tumour cell growth. We therefore examined phenotypic expression of adhesion molecules on the U266 and IM-9 human myeloma-derived cell lines using the panel of monoclonal antibodies (MoAbs) directed at adhesion molecules submitted to the Vth International Conference on Human Leukocyte Differentiation Antigens. U266 and IM-9 myeloma cell lines express mainly CD29, CD49d, VLA-1, CD18, CD54, ICAM-2 and ICAM-3. In contrast, CD49b, VLA-3, CD49f, CD11b, VCAM-1, selectins and selectin-ligands were not expressed on these cell lines. Specific adherence of IM-9 cells to BMSC line LP101 was demonstrated which could be partially blocked by pre-incubation and culture of tumour cells with anti-beta 1 integrin, anti-beta 2 integrin, anti-CD49d, anti-VLA-5, anti-CD11a, anti-CD44 and anti-CD54 MoAbs. The combination of these MoAbs (anti-CD29, CD18, CD11a, CD49d, VLA-5, CD44, CD54, ICAM-2, ICAM-3 MoAbs) decreased but did not completely abrogate binding of IM-9 to BMSCs. Moreover, increases in IL-6 secretion from BMSCs after adherence of IM-9 cells were also partially blocked by these MoAbs. These findings suggest that multiple adhesion pathways may mediate adherence of myeloma cell lines to BMSCs, localizing tumour cells in the marrow microenvironment and triggering IL-6 secretion by BMSCs which may augment tumour cell growth.
A Continued-Fraction Representation of the Time-Correlation Functions (1965)

A continued-fraction expansion of the Laplace transform of the time-correlation functions is obtained, which enables us to express the generalized susceptibilities and the transport coefficients in terms of the static correlation functions of a set of quantities. This expansion has a different feature from the moment and cumulant expansions, and has a convenient form to introduce the long-time approximation as well as the short-time approximation. Its application to the anomalous relaxation and transport phenomena near the second-order phase transition points is discussed. An expansion formula is also obtained for the time evolution of dynamical quantities in order to describe the various modes of motion involved according to their characteristic time constants. These two expansions are closely related to the time-correlation function formalism of irreversible processes, and allow us to have physical intutition in calculating dissipative properties.
Selective stabilization by the bacteriophage 434 repressor of the plasmid expressing bovine growth hormone in Escherichia coli (1988)

The maintenance of a plasmid vector-host system that selects for bacteria carrying the plasmid without the need for antibiotics is described. In this system, the bacteriophage 434 repressor gene cloned on the plasmid protects the host from lysis by a lambda imm434 cI- prophage. Cells that occasionally lose the plasmid are killed by prophage induction and therefore do not accumulate in the growing culture. The presence of the phage 434 repressor in the cells does not interfere with the process of lambda repressor inactivation and the high-level production of bovine growth hormone.
Stevens–Johnson <scp>S</scp>yndrome associated with mogamulizumab treatment of adult <scp>T</scp>‐cell leukemia / lymphoma (2013)

We report an adult T-cell leukemia/lymphoma patient suffering from Stevens-Johnson Syndrome (SJS) during mogamulizumab (humanized anti-CCR4 monoclonal antibody) treatment. There was a durable significant reduction of the CD4(+) CD25(high) FOXP3(+) regulatory T (Treg) cell subset in the patient's PBMC, and the affected inflamed skin almost completely lacked FOXP3-positive cells. This implies an association between reduction of the Treg subset by mogamulizimab and occurrence of SJS. The present case should contribute not only to our understanding of human pathology resulting from therapeutic depletion of Treg cells, but also alert us to the possibility of immune-related severe adverse events such as SJS when using mogamulizumab. We are currently conducting a clinical trial of mogamulizumab for CCR4-negative solid cancers (UMIN000010050), specifically aiming to deplete Treg cells.
Defect monitoring using scanning photoluminescence spectroscopy in multicrystalline silicon wafers (2000)

Scanning photoluminescence (PL) spectroscopy was performed on as-grown and processed multicrystalline silicon (mc-Si) wafers to investigate the defect distribution affecting the efficiency of solar cells. In highly inhomogeneous mc-Si prepared by (i) edge-defined film-fed growth or (ii) a block-casting technique, regions of a wafer with enhanced recombination activity and reduced minority carrier lifetime exhibit an intensive `defect' PL band at room temperature with the maximum at about 0.8 eV. By comparing PL mapping with the distribution of dislocations, we present experimental evidence that the 0.8 eV band corresponds to electrically active dislocation networks. This was confirmed using low-temperature PL spectroscopy, which revealed a characteristic quartet of the dislocation D-lines. One of these dislocation lines, D1, can be tracked as temperature increases and linked to the `defect' band. Strong linear polarization of the 0.8 eV PL band corresponds to a preferential localization of defects in regions with a high level of elastic stress measured with scanning infrared polariscopy. The origin of the 0.8 eV PL band is attributed to dislocations contaminated with impurity precipitates.
Texture segmentation based on wavelet and Kohonen network for remotely sensed images (2003)

In this paper, an approach based on wavelet decomposition and Kohonen's self-organizing map is developed for image segmentation. After performing the 2D wavelet transform of image, some features are extracted for texture segmentation, and the Kohonen neural network is used to accomplish feature clustering. The experimental results demonstrated the satisfactory effect of the proposed approach both for simulated textured image and multi-spectral remotely sensed images.
Pembrolizumab versus ipilimumab for advanced melanoma: Final overall survival analysis of KEYNOTE-006. (2016)

9504 Background: In the phase III KEYNOTE-006 study (NCT01866319), pembro (anti–PD-1) provided superior OS and PFS and a lower incidence of grade 3-5 treatment-related AEs compared with ipi (anti–CTLA-4) in patients (pts) with advanced melanoma and ≤ 1 prior therapy. Here, we present the final OS analysis. Methods: 834 pts were randomized 1:1:1 to 24 mo of pembro 10 mg/kg Q3W or Q2W or to 4 doses of ipi 3 mg/kg Q3W. Clinically stable pts with radiologic progression could receive treatment until confirmed progression. Response was assessed per RECIST v1.1 by central review at wk 12, every 6 wk until wk 48, then every 12 wk thereafter. Survival follow-up was every 12 wk. Final OS analysis occurred after all pts were followed for ≥ 21 mo. Differences in OS were assessed in the intention-to-treat population using the stratified log-rank test with the Hochberg procedure. Results: As of Dec 3, 2015, median follow-up duration was 22.9 mo and 383 pts had died. Pembro continued to provide superior OS, PFS, and ORR over ipi, with no difference between pembro schedules (Table). Median OS was not reached for pembro vs 16.0 mo with ipi; estimated 24-mo OS rates were 55% and 43%, respectively. The PFS KM curves appeared to flatten after ~20 mo for all arms, with estimated 24-mo rates of ~30% for pembro and 14% for ipi. KM estimates suggest ~70% of responding pts have a response lasting ≥ 72 wk. There was 1 treatment-related death (sepsis in the pembro Q2W arm). The safety profile was consistent with that previously reported. Conclusions: With an additional 9 mo of follow-up, median OS was not reached for pembro, and the superiority of pembro over ipi for advanced melanoma was confirmed. Coupled with the durability of response and manageable safety profile, these data support pembro as a standard of care for advanced melanoma. Clinical trial information: NCT01866319. Pembro 10 Q2W N = 279 Pembro 10 Q3W N = 277 Ipi N = 278 OS, median, mo Median, mo NR NR 16.0 24-mo rate, % 55.1 55.3 43.0 HRa (95% CI) 0.68 (0.53-0.87) P = .0008 0.68 (0.53-0.86) P = .0008 — PFS, median, mo Median, mo 5.6 4.1 2.8 24-mo rate, % 31.2 27.8 13.5 HRa (95% CI) 0.61 (0.50-0.75) P < .0001b 0.61 (0.50-0.75) P < .0001b — ORR, % 36.9 P < .0001a,b 36.1 P < .0001a,b 13.3 Responders without further progression, % 72.8 69.0 75.7 aVersus ipi; bNominal.
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing (2011)

Small RNAs loaded into Argonaute proteins direct silencing of complementary target mRNAs. It has been proposed that multiple, imperfectly complementary small interfering RNAs or microRNAs, when bound to the 3' untranslated region of a target mRNA, function cooperatively to silence target expression. We report that, in cultured human HeLa cells and mouse embryonic fibroblasts, Argonaute1 (Ago1), Ago3, and Ago4 act cooperatively to silence both perfectly and partially complementary target RNAs bearing multiple small RNA-binding sites. Our data suggest that for Ago1, Ago3, and Ago4, multiple, adjacent small RNA-binding sites facilitate cooperative interactions that stabilize Argonaute binding. In contrast, small RNAs bound to Ago2 and pairing perfectly to an mRNA target act independently to silence expression. Noncooperative silencing by Ago2 does not require the endoribonuclease activity of the protein: A mutant Ago2 that cannot cleave its mRNA target also silences noncooperatively. We propose that Ago2 binds its targets by a mechanism fundamentally distinct from that used by the three other mammalian Argonaute proteins.
A self-sensing active constrained layer damping treatment for a Euler - Bernoulli beam (1996)

In a self-sensing active constrained layer (SACL) damping treatment, the piezoelectric constraining layer is used simultaneously as both a sensor and an actuator. A variational formulation of ACL damping treatments has shown that an ACL damping treatment using a self-sensing and actuating piezoelectric element as the constraining layer in combination with rate of strain feedback as the control law will ensure that the power dissipated by the active damping always remains positive. This eliminates a major mechanism for system instability. Implementing this self-sensing actuator (SSA) as the constraining layer is made possible through the use of a bridge circuit that subtracts the strain signal from the actuator control voltage in the piezoelectric constraining layer and also differentiates the strain voltage in order to obtain the desired control law.
Impact of IC wafer fab and assembly fab processes on package stress induced product reliability issues - an insight into the package stress relief design rules by simulation (2008)

In this work the impact of the layout of the top metal of the integrated circuit (IC) and the most relevant process and material parameters of IC wafer fab and assembly fab on package stress induced damages to the ICs during temperature cycling is studied by means of thermo-mechanical simulations with experimental verifications. Besides die size, the materials for passivation, silicon thickness, molding compound properties, the cohesion between the molding compound and the die surface, and lead frame yield stress, all are found to significantly influence the risk of damages or failures on the IC surface. The results suggest a more complete package stress relief design rule, pointing to a systematic approach to eliminate or suppress the package stress induced damages to the IC and consequently a possibly more efficient use of the silicon area in IC design.
Anthracyclines and Heart Failure (2013)

Doxorubicin and other anthracyclines are used to treat cancer, yet they elevate the risk of heart failure. A recent study provides insight into how doxorubicin causes heart failure and points to research strategies for reducing risk.
AKAP150-Mediated TRPV1 Sensitization is Disrupted by Calcium/Calmodulin (2011)

the results from these studies indicate that calcium/calmodulin interferes with the association of AKAP150 with TRPV1, potentially extending resensitization of the channel.
PiLoc: a self-calibrating participatory indoor localization system (2014)

While location is one of the most important context information in mobile and ubiquitous computing, large-scale deployment of indoor localization system remains elusive.In this work, we propose PiLoc, an indoor localization system that utilizes opportunistically sensed data contributed by users. Our system does not require manual calibration, prior knowledge and infrastructure support. The key novelty of PiLoc is that it merges walking segments annotated with displacement and signal strength information from users to derive a map of walking paths annotated with radio signal strengths.We evaluate PiLoc over 4 different indoor areas. Evaluation shows that our system can achieve an average localization error of 1.5m.