gebhart/patrepeval huggingface dataset:
Crystallization kinetics of polyethylene terephthalate. II. Dynamic crystallization of PET (1987)

The crystallization behavior of polyethylene terephthalate (PET), was investigated under isothermal and dynamic cooling conditions, as a function of molecular weight, polycondensation catalyst system, and polymerization conditions. Crystallization kinetic parameters were calculated for both cases by utilizing Avrami-type expressions. Analysis of the crystallization kinetic data indicates that the same mechanism is operative under isothermal and dynamic cooling crystallization conditions. The dynamic cooling crystallization method can establish the minimum cooling rate required to produce PET without detectable crystallinity. The results show that the cooling requirements for producing noncrystalline PET are dependent on the molecular weight of the resin, but more importantly, are dependent on the catalyst system used in the polycondensation step. These results are in good agreement with the results obtained under isothermal conditions.
Experiences with an object-oriented mapper for coherent distributed shared memory (2003)

The paper gives an overview of the implementation of an object-oriented server using the NIH (National Institut of Health) class library. The server was implemented on top of the Chorus microkernel and uses the Chorus external mapper interface. The use of the NIH class library significantly simplified the object-oriented design and implementation of the server, due to the predefined classes and the stringent concept in the library framework.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Increased susceptibility to osmotic disruption of the blood-brain barrier in chronic hypertension. (1984)

We examined the effects of chronic hypertension and acute reduction of arterial pressure on the susceptibility of the blood-brain barrier (BBB) to disruption. The BBB was disrupted with an intracarotid injection of 1.6 M arabinose in spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and normotensive Wistar-Kyoto (WKY) rats. Permeability of the BBB was determined from the ratio of 125I-albumin in brain to 125I-albumin in blood. When the BBB was intact, permeability was less than 0.4%. After hypertonic arabinose, permeability of the BBB was greater (mean +/- SE) in SHRSP (17.6% +/- 1.6%) and in SHR (21.1% +/- 3.1%) than in WKY (10.3% +/- 2.4%) (p less than 0.05). When arterial pressure of SHRSP was reduced acutely with nitroprusside before arabinose, the BBB permeability to albumin was not reduced (21.5% +/- 1.5%). In other rats, we examined survival after osmotic disruption. In SHRSP, 14 of 15 rats died within 1 day after osmotic disruption with marked cerebral edema. In WKY, four of 15 rats died (p less than 0.05 vs SHRSP). When arterial pressure of SHRSP was reduced before arabinose, mortality was reduced to six of 15 (p less than 0.05 vs untreated SHRSP). We conclude that the BBB in SHRSP has enhanced vulnerability that is detrimental to survival. Reduction of arterial pressure improves survival in SHRSP without affecting BBB permeability to albumin.(ABSTRACT TRUNCATED AT 250 WORDS)
CARCINOMA OF THE PERIPAPILLARY PORTION OF THE DUODENUM (1939)

LIEBER, MARSHALL M. M.D.; STEWART, HAROLD L. M.D.; LUND, HERBERT M.D. Author Information
MODELING RF HEATING OF ACTIVE IMPLANTABLE MEDICAL DEVICES DURING MRI USING SAFETY INDEX (2007)

Ankara : The Department of Electrical and Electronics Engineering and the Institute of Engineering and Sciences of Bilkent University, 2007.
Novel In Situ Pretreatment Method for Significantly Enhancing the Signal In MALDI-TOF MS of Formalin-Fixed Paraffin-Embedded Tissue Sections (2012)

The application of matrix-assisted laser desorption/ionization (MALDI)-based mass spectrometry (MS) to the proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissue presents significant technical challenges. In situ enzymatic digestion is frequently used to unlock formalin-fixed tissues for analysis, but the results are often unsatisfactory. Here, we report a new, simplified in situ pretreatment method for preparing tissue sections for MS that involves heating with vapor containing acetonitrile in a small airtight pressurized space. The utility of the novel method is shown using FFPE tissue of human colon carcinoma. The number and intensity of MALDI peaks obtained from analysis of pretreated tissue was significantly higher than control tissue not subjected to pretreatment. A prominent peak (m/z 850) apparently specific to cancerous tissue was identified as a fragment of histone H2A in FFPE tissue pretreated using our method. This highly sensitive treatment may enable MALDI-MS analysis of archived pathological FFPE samples, thus leading to the identification of new biomarkers.
Clinical Protocols for the Isolation and Expansion of Mesenchymal Stromal Cells (2008)

SUMMARY: Multipotent mesenchymal stromal cells (MSCs) are currently exploited in numerous clinical trials to investigate their potential in immune regulation, hematopoiesis, and tissue regeneration. The low frequency of MSCs necessitates cell expansion to achieve transplantable numbers. The challenge is to assure safe and high-quality cell production. GMP(Good Manufacturing Practice)-graded cell processing such as cell preparation, culture, and manipulation is mandatory for the progress of such advanced cell therapy. This review summarizes protocols to isolate MSCs from bone marrow and adipose tissue and to expand MSCs for clinical use focussing on culture media composition as well as culture devices and assays to ensure and control quality of the final product.
On-Line Detection of Polymer Melt Flow Instabilities in a Capillary Rheometer (2010)

Polymer melt flow instabilities limit the optimum throughput conditions in the plastic processing industry with high economic and environmental consequences. A new set-up able to measure on-line pressure fluctuations inside a slit-die arising from polymer melt flow instabilities is introduced by using a capillary rheometer. This set-up consists of three high sensitive piezoelectric pressure transducers located inside a slit-die together with the application of advanced mathematical tools to process the acquired time dependent pressure signals. Our novel tool improves the time resolution by a factor of ∼10 3 and under optimum conditions pressure fluctuations about 10 -5 bar can be detected. Examples of these pressure oscillations arising from the main melt flow instabilities typically observed during extrusion based processes of commercial polyethylenes are presented.
Novel fabrication method of quarter-wave-shifted gratings using ECR-CVD SiN <sub>x</sub> films (1987)

Quarter-wave-shifted gratings were fabricated by novel methods using ECR-CVD SiN, films. SiNx films deposited on photoresist and grooves have a higher etching rate than those deposited on the flat substrate. We made good use of this difference to fabricate the quarter-wave-shifted gratings with a 240 nm period, about 150nm depth and narrow transient regions.
Embedding Overlap Priors in Variational Left Ventricle Tracking (2009)

We propose to embed overlap priors in variational tracking of the left ventricle (LV) in cardiac magnetic resonance (MR) sequences. The method consists of evolving two curves toward the LV endo- and epicardium boundaries. We derive the curve evolution equations by minimizing two functionals each containing an original overlap prior constraint. The latter measures the conformity of the overlap between the nonparametric (kernel-based) intensity distributions within the three target regions--LV cavity, myocardium and background-to a prior learned from a given segmentation of the first frame. The Bhattacharyya coefficient is used as an overlap measure. Different from existing intensity-driven constraints, the proposed priors do not assume implicitly that the overlap between the intensity distributions within different regions has to be minimal. This prevents both the papillary muscles from being included erroneously in the myocardium and the curves from spilling into the background. Although neither geometric training nor preprocessing were used, quantitative evaluation of the similarities between automatic and independent manual segmentations showed that the proposed method yields a competitive score in comparison with existing methods. This allows more flexibility in clinical use because our solution is based only on the current intensity data, and consequently, the results are not bounded to the characteristics, variability, and mathematical description of a finite training set. We also demonstrate experimentally that the overlap measures are approximately constant over a cardiac sequence, which allows to learn the overlap priors from a single frame.
Activation of Rac1 Is Closely Related to Androgen-Independent Cell Proliferation of Prostate Cancer Cells Both in Vitro and in Vivo (2010)

We and others previously showed that signaling through cSrc or atypical protein kinase C (aPKC) pathway regulates the proliferation of prostate cancer cells and is associated with their progression to castrate-resistance in vivo. However, the interrelation of these two kinases has been largely unexplored. In the present study, we show that androgen-induced activation of cSrc regulates the activity of aPKC through the small molecular weight G protein Rac1 in androgen-dependent LNCaP cells. Knockdown of cSrc in those cells reduces the phosphorylation of aPKC and the abundance of activated form of Rac1. Additionally, the treatment of those cells with Rac1 inhibitor repressed cell cycle progression at G(1)/S transition. In fact, forced expression of a constitutively active Rac1 mutant in LNCaP cells promoted cell proliferation under androgen-depleted conditions both in vitro and in vivo. Moreover, LNCaP C4-2 and AILNCaP cells, the syngeneic androgen-independent sublines from LNCaP cells, harbored abundant Rac1-GTP. Importantly, the inhibition of Rac1 suppressed cell proliferation and induced apoptotic cell death in all prostate cancer cell lines tested irrespective of their androgen-dependence. In immunohistochemical evaluation of tumor specimens from prostate cancer patients, Rac1 pathway appeared to be activated in the majority of castrate-resistant diseases. Collectively, our present results both in vitro and in vivo highly implicate that Rac1 can be a potential therapeutic target for patients with advanced prostate cancer, especially those with castrate-resistant status.
Iron-responsive element-binding protein. Phosphorylation by protein kinase C. (1993)

The iron-responsive element-binding protein (IRE-BP) is a cytosolic RNA-binding protein that functions in the maintenance of iron homeostasis by post-transcriptionally regulating transferrin receptor and ferritin synthesis. Little is known concerning how factors other than iron may modulate the activity of this central regulator of cellular iron utilization. We present evidence indicating that phosphorylation of the IRE-BP by protein kinase C (PKC) could provide a mechanism for regulation of IRE-BP function. Purified rat liver IRE-BP was phosphorylated by PKC up to 1.3 mol of phosphate/mol of protein with Ser the modified amino acid. Ser was also the phosphoacceptor in the IRE-BP in intact cells. The Km of PKC for the IRE-BP was 0.4 microM. Tryptic phosphopeptide mapping identified one major phosphopeptide plus several other peptides with lesser amounts of phosphate. Synthetic peptides of the IRE-BP containing Ser 138 (site A) and Ser 711 (site B) were phosphorylated by PKC. In HL 60 cells, addition of phorbol 12-myristate 13-acetate (PMA) stimulated IRE-BP phosphorylation within 30 min and increased high affinity IRE RNA binding activity 2-fold. After 90 min, the level of phosphorylation had increased further, and high affinity IRE RNA binding activity had increased 3-fold above the control. Incorporation of [35S]Met into immunoprecipitable IRE-BP was not altered in cells treated with PMA for 30 or 90 min. PMA also stimulated IRE-BP phosphorylation in rat fibroblasts. Taken together, our studies begin to define a novel mechanism by which hormones, growth factors, and other agents may regulate cellular iron utilization through specific phosphoregulation of the IRE-BP.
Matteuorienate A and B, Two New and Potent Aldose Reductase Inhibitors from Matteuccia orientalis (HOOK.)TREV. (1994)

Matteuorienate A and B, two new C-methyl flavanone derivatives, were isolated from the Matteuccia orientalis (Hook.) Trev. (Aspidiaceae), and their structures were determined by the use of spectroscopic methods including 2D-NMR (1H-1H COSY, 1H-13C COSY and 1H-13C long-range COSY) experiments and chemical methods. Both the compounds were found to be very strong inhibitors of aldose reductase among the natural products.
Efficient Algorithm for Determining the Optimal Execution Strategy for Path Queries in OODBS (1996)

. To select an optimal query evaluation strategy for a path query in an object-oriented database system one has to exploit the available index structures on the path. In a database with a large database schema many alternative strategies have to be considered for the evaluation of a path query by choosing from a large set of available indices, which can make the selection of the optimal strategy expensive. We give an algorithm that finds the optimal strategy for evaluating a path query with time complexity independent of the set of indices available in the database. The algorithm considers all possible forward andbackward traversal strategies and has time complexity O(n 2 ) in the path length n. Incorporating this algorithm into the query optimization for object-oriented database management systems can improve the response time of the system, by optimizing an equally important and frequent type of queries with high efficiency. Key Words. Object-oriented databases, Index selection, ...
Issues on software testing for safety-critical real-time automation systems (2005)

Software quality indicates how well the software product complies with the user requirements. The challenge in software testing is how to uncover the difficult-to-find software problems. Networked and embedded real-time automation software in safety-critical applications such as avionics software poses unique concerns about software quality due to its demanding requirements on system performance. The benefits of the rigorous software development and verification processes include both functional and nonfunctional software performance assurance. The heart of safety-critical software development lies in processes and techniques for software validation and verification. The effective software testing can ensure the software quality as well as make the developer garner, the customer kudos for the high software quality.
ECG-based gating in ultra high field cardiovascular magnetic resonance using an independent component analysis approach (2013)

The presented ICA-based method allows the estimation and identification of an IC dominated by the ECG signal. R-peak detection based on this IC outperforms the state-of-the-art VCG-based technique in a 7 T MR scanner environment.
Stark Effect on Impurity Levels in Diamond (1969)

In this article we present our experimental results on the Stark effect of the shallow impurity levels of $p$-type semiconducting diamond (IIb). The shift of the levels is found to be quadratic in the applied electric field, and to tend towards the ground state. No splitting of the fourfold degenerate levels was observed; instead, a broadening of the levels, quadratic in the field, is attributed to an unresolved splitting. The over-all behavior of the spectrum agrees with the group-theoretical predictions, and the estimated Stark coefficients are in reasonable relation with those of silicon and germanium.
Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes (1995)

Mutations in the Drosophila dunce gene, the structural gene for a cAMP-specific phosphodiesterase (PDE), disrupt normal learning and memory and lead to female sterility. Our experiments address a long-standing question in the genetic dissection of learning and memory of whether dnc is involved in physiological processes underlying learning. Conditional expression of dunce transgenes in dnc adults shortly before training significantly improves learning over nontransgenic controls. Remarkably, behavioral rescue was also observed after induction of a transgene carrying a rat counterpart of dunce. Induction of the transgenes in adult dnc females confers partial rescue of the female sterility phenotype. These data are consistent with a major physiological requirement for the gene's activity in the learning process and show that a rat counterpart can substitute functionally for the Drosophila gene.
Detection and Direct Genomic Sequencing of Multiple Rare Unknown Flanking DNA in Highly Complex Samples (2001)

By identifying the sequence of retro- and lentiviral integration sites in peripheral blood leukocytes, the clonal composition and fate of genetically modified hematopoietic progenitor and stem cells could be mapped in vitro and in vivo. Previously available methods have been limited to the analysis of mono- or oligoclonal integration sites present in high copy numbers. Here, we perform characterization of multiple rare retroviral and lentiviral integration sites in highly complex DNA samples. The reliability of this method results from nontarget DNA removal via magnetic extension primer tag selection (EPTS) preceding solid-phase ligation-mediated PCR. EPTS/LM-PCR allowed the simultaneous direct genomic sequencing of multiple proviral LTR-flanking sequences of retro- and lentiviral vectors even if only 1 per 100 to 1000 cells contained the provirus. A primer walking "around" the integration locus demonstrated the adaptability of EPTS/LM-PCR to study unknown flanking DNA regions unrelated to proviruses. The technique is fast, inexpensive, and sensitive in minimal samples. It enables studies of retro- and lentiviral integration, viral vector tracking in gene therapy, insertional mutagenesis, transgene integration, and direct genomic sequencing that until now have been difficult or impossible to perform.
The Publication and Profits of Dryden's <i>Virgil</i> (1938)

Dryden's profits from the publication of his translation of Virgil have long been a topic of considerable interest and speculation. Malone, in 1800, pieced together as much information as he could gather from secondary sources then available to him; but he was explicit in regarding as fragmentary his interpretations of Dryden's profit from this work. The whole question is indissolubly bound up with the agreement between Dryden and his publisher, Jacob Tonson, for the publication of the translation.
Equality in Asia-Pacific : reality or a contradiction in terms? (2008)

1. Equality in Asia-Pacific: Reality or a Contradiction in Terms? - An Introduction 2. What's in a Name? Bisexuality, Transnational Sexuality Studies and Western Colonial Legacies 3. Same-Sex Marriage/Constitutionalism and their Centrality to Equality Rights in Hong Kong: A Comparative-Socio-Legal Appraisal 4. Changing Times, Changing Minds, Changing Laws - Sexual Orientation and New Zealand Law, 1960 to 2005 5. The Same-Sex Marriage Debate in Australia 6. Non-Governmental Organising for Gender Equality in China - Joining a Global Emancipatory Epistemic Community 7. On China's Slow Boat to Women's Rights: Revisions to the Women's Protection Law, 2005 8. Inequality of Educational Opportunity in Korea by Gender, Socioeconomic Background, and Family Structure 9. Official Languages and Bilingualism in the Courtroom: Hong Kong, Canada, the Republic of Ireland, and International Law 10. Constitutionalising Affirmative Action in the Fiji Islands
Multi-objective learning control for robotic manipulator (2003)

Abstract Several types of learning controllers have been proposed in the literature to improve the tracking performance of robot manipulators. In most cases, the learning algorithms emphasize mainly on a single objective of learning a desired motion of the end‐effector. In some applications, more than one objective may be specified at the same time. For example, a robot may be required to follow a desired trajectory (primary objective) and at the same time avoid an obstacle (secondary objective). Thus, multi‐objective learning control can be more effective to realize the collision‐free tasks. In this paper, a multi‐objective learning control problem is formulated and solved. In the proposed learning control system, the primary objective is to track a desired end‐effector's motion and several secondary objectives can be specified for the desired orientation and for obstacles avoidance. To avoid obstacles in the workspace, a new learning concept called “region learning control” is also proposed in this paper. The proposed learning controllers do not require the exact knowledge of robot kinematics and dynamics. Sufficient condition is presented to guarantee the convergence of the learning system. The proposed learning controllers are applied to a four‐link planar redundant manipulator and simulation results are presented to illustrate the performance. © 2004 Wiley Periodicals, Inc.
A New Graph-Based Molecular Descriptor Using the Canonical Representation of the Molecule (2014)

Molecular similarity is a pervasive concept in drug design. The basic idea underlying molecular similarity is the similar property principle, which states that structurally similar molecules will exhibit similar physicochemical and biological properties. In this paper, a new graph-based molecular descriptor (GBMD) is introduced. The GBMD is a new method of obtaining a rough description of 2D molecular structure in textual form based on the canonical representations of the molecule outline shape and it allows rigorous structure specification using small and natural grammars. Simulated virtual screening experiments with the MDDR database show clearly the superiority of the graph-based descriptor compared to many standard descriptors (ALOGP, MACCS, EPFP4, CDKFP, PCFP, and SMILE) using the Tanimoto coefficient (TAN) and the basic local alignment search tool (BLAST) when searches were carried.
L'Islam Noir (1925)

L'Islam Noir L'Islam Noir. By Capitaine P.-J. André. (Paris: Paul Geuthner. 1924. Pp. . 7 francs 50.) E. W. S. E. W. S. Search for other works by this author on: Oxford Academic Google Scholar African Affairs, Volume XXV, Issue XCVII, October 1925, Pages 98–99, https://doi.org/10.1093/oxfordjournals.afraf.a100704 Published: 01 October 1925