gebhart/patrepeval huggingface dataset:
Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore (2016)

Mitochondrial permeability transition pore (mPTP) is a large channel located in the mitochondrial inner membrane. The opening of mPTP during pathological calcium overload leads to the membrane depolarization and disruption of ATP production. mPTP activation has been implicated as a central event during the process of stress-induced cell death. mPTP is a supramolecular complex composed of many proteins. Recent studies suggest that mitochondrial ATPase plays the central role in the formation of mPTP. However, the structure of the central conducting pore part of mPTP (mPTPore) remains elusive. Here we review current models proposed for the mPTPore and involvement of polyP in its formation and regulation. We discuss the underestimated role of polyP as an effector and a putative structural component of the mPTPore. We propose the hypothesis that inclusion of polyP can explain such properties of mPTP activity as calcium activation, selectivity and voltage-dependence.
Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system (1997)

Escherichia coli accumulates malto-oligosaccharides by the maltose transport system, which is a member of the ATP-binding-cassette (ABC) superfamily of transport systems. The proteins of this system are LamB in the outer membrane, maltose-binding protein (MBP) in the periplasm, and the proteins of the inner membrane complex (MalFGK2), composed of one MalF, one MalG, and two MalK subunits. Substrate specificity is determined primarily by the periplasmic component, MBP. However, several studies of the maltose transport system as well as other members of the ABC transporter superfamily have suggested that the integral inner membrane components MalF and MalG may play an important role in determining the specificity of the system. We show here that residue L334 in the fifth transmembrane helix of MalF plays an important role in determining the substrate specificity of the system. A leucine-to-tryptophan alteration at this position (L334W) results in the ability to transport lactose in a saturable manner. This mutant requires functional MalK-ATPase activity and the presence of MBP, even though MBP is incapable of binding lactose. The requirement for MBP confirms that unliganded MBP interacts with the inner membrane MalFGK2 complex and that MBP plays a crucial role in triggering the transport process.
Resonant cavity for the stimulated emission of x rays (1989)

Rate equations are proposed which describe the operation of a crystal as a resonant cavity for x rays. The formalism, which applies equally well to two-beam or multibeam diffraction cases, is not restricted to any particular mechanism of x-ray emission. It automatically takes into account dynamical diffraction effects on energy flow (group velocity) and absorption (the Borrmann effect) which are shown to be instrumental in increasing gain and lowering the lasing threshold. The resonant x-ray modes are those for which the group velocity vanishes (the resonant diffraction condition).
Time Perception Machine: Temporal Point Processes for the When, Where and What of Activity Prediction (2018)

Numerous powerful point process models have been developed to understand temporal patterns in sequential data from fields such as health-care, electronic commerce, social networks, and natural disaster forecasting. In this paper, we develop novel models for learning the temporal distribution of human activities in streaming data (e.g., videos and person trajectories). We propose an integrated framework of neural networks and temporal point processes for predicting when the next activity will happen. Because point processes are limited to taking event frames as input, we propose a simple yet effective mechanism to extract features at frames of interest while also preserving the rich information in the remaining frames. We evaluate our model on two challenging datasets. The results show that our model outperforms traditional statistical point process approaches significantly, demonstrating its effectiveness in capturing the underlying temporal dynamics as well as the correlation within sequential activities. Furthermore, we also extend our model to a joint estimation framework for predicting the timing, spatial location, and category of the activity simultaneously, to answer the when, where, and what of activity prediction.
Tree Sampling for Detection of Information Source in Densely Connected Networks (2019)

We investigate the problem of source detection in information spreading throughout a densely-connected network. Previous works have been developed mostly for tree networks or applied the tree-network results to non-tree networks assuming that the infection occurs in the breadth first manner. However, these approaches result in low detection performance in densely-connected networks, since there is a substantial number of nodes that are infected through the non-shortest path. In this work, we take a two-step approach to the source detection problem in densely-connected networks. By introducing the concept of detour nodes, we first sample trees that the infection process likely follows and effectively compare the probability of the sampled trees. Our solution has low complexity of O ( n 2 log n ) , where n denotes the number of infected nodes, and thus can be applied to large-scale networks. Through extensive simulations including practical networks of the Internet autonomous system and power grid, we evaluate our solution in comparison with two well-known previous schemes and show that it achieves the best performance in densely-connected networks.
A SURVEY OF COMPUTER VISION METHODS FOR LOCATING FRUIT ON TREES (2000)

A review of previous studies to automate the location of fruit on trees using computer vision methods wasperformed. The main features of these approaches are described, paying special attention to the sensors and accessoriesutilized for capturing tree images, the image processing strategy used to detect the fruit, and the results obtained in termsof the correct/false detection rates and the ability to detect fruit independent of its maturity stage. The majority of theseworks use CCD cameras to capture the images and use local or shape-based analysis to detect the fruit. Systems usinglocal analysis, like intensity or color pixel classification, allow for rapid detection and were able to detect fruit at specificmaturity stages, i.e., fruit with a color different from the background. However, systems based on shape analysis weremore independent of hue changes, were not limited to detecting fruit with a color different from the color of thebackground; however, their algorithms were more time consuming. The best results obtained indicate that more than 85%of visible fruits are usually detectable, although with CCD sensors there were a number of false detections that in mostcases were above >5%. The approaches using range images and shape analysis were capable of detecting fruit of anycolor, did not generate false alarms, and gave precise information about the fruit three-dimensional position. In spite ofthese promising results, the problem of total fruit occlusion limits the amount of fruit that can be harvested, ranging from40 to 100% of total fruit, depending on fruiting and viewing conditions. This fact seriously affects the feasibility of futureharvesting robots relying on images that do not contain a high percentage of visible fruit. Therefore, new techniques toreduce total occlusion should be studied in order to make the process feasible.
A Modified Device for Collecting Milk from Guinea Pigs (1979)

A modified device for milking small animals is discussed. The advantage of these modifications are 1) quiet operation, 2) ease of operation in animal room, and 3) quick change to allow the same device to be used on different animals. This device can be tailored to the test size as well as milk volume expected. Construction is simple, and materials are inexpensive.
Synthesis of the Metal-Organic Framework UiO-66 in the Form of Nanoparticles with a Modified Surface (2021)

We report on a synthesis procedure for obtaining a UiO-66 metal-organic framework in the form of nanoparticles with a modified surface. A distinctive feature of the developed procedure is that modification occurs directly during synthesis. Biocompatible polyethylene glycol (PEG) is selected as the organic polymer covering the surface of the UiO-66 nanoparticles. The effect of the degree of PEG polymerization on the size, morphology, and surface charge of UiO-66 nanoparticles is studied. The presence of PEG molecules is confirmed by infrared (IR) spectroscopy. The materials obtained are single phase and characterized by a high degree of crystallinity. The particle size varies from 80 to 120 nm, depending on the type of PEG used. A high surface charge in an aqueous medium (ζ-potential over 20 mV) indicates the possibility of forming a stable suspension. Thus, the obtained materials are promising as nanocontainers for the delivery of biologically active substances.
Xf Phage Invading the Host Cells with their Protein Coats (1976)

The Xf phage coat protein associated with infected cells could not be removed by washing with antiserum and tris-EDTA buffer. Although the infected cells were consecutively washed 6 times with tris-EDTA buffer, the ratios of parental phage 6H-DNA to 14C-protein were not changed. A considerable amount of the parental 14C-protein and 3H-DNA in the original ratio were detected in the membrane and the soluble cytoplasmic fractions of infected cells. The studies of the change in Xf 14C-protein and 3H-DNA incorporation into the host cells and their release showed that DNA and protein penetrate together into the host cells during the first 60 min after infection (p.i.). While virtually all parental DNA was conserved, re-utilized and released from the infected cell 60 min p.i., no apparent release of parental protein was observed. Approx. 40% of the parental protein became degraded and could be washed from the infected cell after 90 min; the rest of the parental protein remained and probably was re-utilized by the host.
Effects of Mg/Si Ratio on Microwave Dielectric Characteristics of Forsterite Ceramics (2007)

Nonstoichiometric Mg 2 SiO 4 forsterite dielectric ceramics with various Mg/Si ratios ( R =2.025, 2.05, and 2.2) were prepared and characterized. The appearance of a MgSiO 3 secondary phase could be effectively suppressed by adjusting the nonstoichiometry, and a single‐phase forsterite structure was obtained in the present ceramics with Mg/Si ratios of 2.025 and 2.05. The microwave dielectric characteristics were significantly improved in the nonstoichiometric Mg 2 SiO 4 ceramics on eliminating the MgSiO 3 secondary phase, where an enhanced Q × f value and a suppressed temperature coefficient of resonant frequency λ f were obtained. The best microwave characteristics were achieved in the nonstoichiometric forsterite ceramics with an Mg/Si ratio of 2.05: ɛ r =7.5, Q × f =114 730 GHz, and λ f =−59 ppm/°C.
Efficient, Balanced Data Placement Algorithm in Scalable Storage Clusters (2007)

Data distribution and load balancing become increasingly important in large-scale distributed storage system. This paper focuses on the problem of designing an optimal, self-adaptive strategies for balanced distribution and reorganization of replicated objects among a dynamically heterogeneous nodes, and presents a novel decentralized algorithm, Dynamic Interval Mapping, which maps replicated objects to a scalable collection of nodes, it distributes objects to nodes optimally, redistributing minimum amount of objects when new nodes are added or existing nodes are removed to maintain the balanced distribution. It supports weighted allocation and guarantees that replicas of a particular object are not placed on the same node. The time complexity and storage requirements are superior to previous methods.
Cultured epidermal grafts in the treatment of leg ulcers. (1990)

Cultured epidermal grafts offer a major advance in the treatment of burns and other disabling skin wounds in which there are few other available treatments. Cultured allografts offer immediate availability, obviating skin biopsies. Theoretically, they could be grown in advance, cryopreserved, and stored in skin banks. They provide rapid coverage of wounds and produce prompt relief of pain and healing that continues for many weeks after the graft has been applied. Their mechanism of action has not been elucidated, but it seems likely that the allografted cells do not survive permanently and are gradually replaced by host epithelial cells. Release of growth factors by cultured allografts may contribute significantly to their wound healing properties. Whatever their mechanism of action, they promote rapid epithelialization at least in small chronic wounds. Especially for the elderly patient with nonhealing ulcers, they offer an alternative treatment option that is simple, painless, and noninvasive.
Vascular imaging with a three-dimensional power Doppler system. (1995)

September 1995Vascular imaging with a three-dimensional power Doppler system.Authors: D B Downey and A FensterAuthor Info & AffiliationsVolume 165, Issue 3https://doi.org/10.2214/ajr.165.3.7645492 METRICS PDFotherformats
Nonuniform sampling and spiral MRI reconstruction (2000)

There is a natural formulation of the Classical Uniform Sampling Theorem in the setting of Euclidean space, and in the context of lattices, as sampling sets, and unit cells E, e.g., the Voronoi cell. For sampling at the Nyquist rate, the sampling function corresponds to the since function, and it is an integral over E. The set E is a tile for Euclidean space under translation by elements of the reciprocal lattice. We have a constructive, implementable non-uniform sampling theorem in the context of uniformly discrete sampling sets and sets E, corresponding to the unit cells of the uniform sampling result. The set E has the property that the translates by the sampling set of the polar set of E is a covering of Euclidean space. The theorem depends on the theory of frames, and can be viewed as a modest generalization of a theorem of Beurling. The application herein is to fast magnetic resonance imagine by direct signal reconstruction from spectral data on spirals.
Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion‐induced injury (2008)

Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion‐injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti‐STAT1 activity.
Autologous Fat Grafting: The Science Behind the Surgery (2016)

An invaluable part of the plastic surgeon's technical arsenal for soft tissue contouring, fat grafting continues to be plagued by unpredictable outcomes, resulting in either reoperation and/or patient dissatisfaction. Thus, extensive research has been conducted into the effects of adipose tissue procurement, processing, and placement on fat graft quality at both the cellular level and in terms of overall volume retention. Herein, we present an overview of the vast body of literature in these areas, with additional discussion of cell-assisted lipotransfer as a therapy to improve volume retention, and on the controversial use of autologous fat in the setting of prior irradiation.
Portrayal of Controversial and Difficult Issues in Aboriginal Teacher Education or Silent Betrayal of Expectations. A response to Paul Buckley's article (Vol. 24, No. 1) (1996)

Despite the introductory ‘rider’ being provided so that readers be ‘advised to remain aware of the possible cultural bias resulting’ from the fact that ‘those interviewed, although possessing vast experience of Aboriginal education are non-aboriginal people’ (p. 26), Buckley's article is a confused and poorly articulated comment on the views of a small number of non-Aboriginal educators relating to attendant issues to implementation of the Batchelor College Teacher Education program. Buckley gets off to a poor start by not getting the name of the program correct. His Remote Access Teacher Education program is in fact known as the Remote Area Teacher Education (RATE) program and has been referred to as this for most of the last fifteen years.
Solid-Phase Biomimetic Synthesis of Carpanone-like Molecules (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolid-Phase Biomimetic Synthesis of Carpanone-like MoleculesCraig W. Lindsley, Lawrence K. Chan, Brian C. Goess, Reni Joseph, and Matthew D. ShairView Author Information Department of Chemistry & Chemical Biology Harvard University, 12 Oxford St. Cambridge, Massachusetts 02138 Harvard Institute of Chemistry & Cell Biology Harvard Medical School, Boston, Massachusetts 02136 Cite this: J. Am. Chem. Soc. 2000, 122, 2, 422–423Publication Date (Web):December 31, 1999Publication History Received13 October 1999Published online31 December 1999Published inissue 1 January 2000https://pubs.acs.org/doi/10.1021/ja993674mhttps://doi.org/10.1021/ja993674mrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1320Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (4)»Supporting Information Supporting Information SUBJECTS:Biotechnology,Chemical reactions,Chemical synthesis,Diversity oriented synthesis,Molecules Get e-Alerts
A Study of Locking Phenomena in Oscillators (1946)

Impression of an external signal upon an oscillator of similar fundamental frequency affects both the instantaneous amplitude and instantaneous frequency. Using the assumption that time constants in the oscillator circuit are small compared to the length of one beat cycle, a differential equation is derived which gives the oscillator phase as a function of time. With the aid of this equation, the transient process of "pull-in" as well as the production of a distorted beat note are described in detail. It is shown that the same equation serves to describe the motion of a pendulum suspended in a viscous fluid inside a rotating container. The whole range of locking phenomena is illustrated with the aid of this simple mechanical model.
Synthesis of Glycidyl Methacrylate Copolymers and Improving of Polypropylene Fiber Dyeability by Means of Polymer-blending with it (1963)

ポリプロピレン繊維の染色性改良を目的として,グリシジルメタクリレートとスチレンおよびビニルトルエンの共重合体を合成して,それをポリプロピレンと混合紡糸した。この繊維は分散染料により染色されるが,これをさらにアミン化合物および亜硫酸化合物で処理してエポキシ基に付加反応せしめたものは,それぞれ酸性染料,塩基性染料にたいして淡色ではあるが染色性を有するようになった。これに関連して,共重合体の熱安定性,アミンとの反応性,ポリプロピレンとの混合状態などもしらべた。
Etude sur l'hydrogénation catalytique de la vanilline. Sur un vanillyl‐créosol (1939)

Abstract L'hydrogénation de la vanilline, en présence d'acide acétique et de charbon palladié, à la pression atmosphérique et à la température du laboratoire, donne, à côté du créosol, une forte proportion de méthyl‐2‐dioxy‐4′,5‐diméthoxy‐3′,4‐diphénylméthane.
Airport Master Planning: Airport Design by Economic Analysis (Increasing Airport Capacity An ASCE-AOC Joint Conference 1961) (1961)

The factors that affect practical airport capacity are enumerated, and quantitative examples of their effects are given. An analysis technique is described for accurately predicting the practical airport capacity in terms of operating rate and delay. This technique is then used to show how economic analysis can be used to determine when a proposed project can be economically justified, or which of several possible solutions is the most economical.
Neural network techniques applied to channel equalization in indoor radio environment (2002)

Indoor communications are affected by multipath propagation that imposes an upper limit on the system data rate and restricts their possible applications. In order to overcome the degrading effect introduced by the channel, conventional equalizers, based in digital filters, have been traditionally used. In this paper a new approach based on neural networks is considered. In particular the behavior of multilayer perceptron (MLP) structures applied to the channel equalization of cellular radio indoor environments for 4-QAM modulation is analyzed. In this case the system performance becomes limited by the co-channel interference rather than by the noise and, again, the equalization techniques based on MLP structures may be an effective tool in order to fight this degradation effect.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
THE MANNICH REACTION OF DIALKYL KETONES, AROMATIC ALDEHYDES AND AROMATIC AMINES (1996)

(1996). THE MANNICH REACTION OF DIALKYL KETONES, AROMATIC ALDEHYDES AND AROMATIC AMINES. Organic Preparations and Procedures International: Vol. 28, No. 5, pp. 618-622.
Power management of pulsed-index communication protocols (2015)

Pulsed-Index Communication (PIC) is a novel technique for single-channel, high-data-rate, low-power dynamic signaling that does not require any clock and data recovery (CDR). It is fully adapted to the simple yet robust communication needs of IoT devices and sensors. Prior work has focused on the power savings that this protocol can achieve as a result of the elimination of circuitry devoted to clock and data recovery. In this paper, we show that further power saving can be achieved using the duty cycle of the pulse as a power control parameter. This power control policy is applied to a single-wire link with significant power saving achieved above and beyond the savings due to the CDR elimination. These power savings are obtained without any impact on data rate. The pulse control policy is implemented using 45nm CMOS technology and verified on various, single-channel communication links.