gebhart/patrepeval huggingface dataset:
One-Pot Synthesis of Block Copolymer Coated Cobalt Nanocrystals (2005)

Reported in this paper is the preparation of ε-Co nanocrystals coated by a monolayer of poly(acrylic acid)-block-polystyrene or PAA−PS. This method is adopted from one using oleic acid as the surfactant. The replacement of oleic acid by PAA−PS as the surfactant during Co nanoparticle preparation yields Co/PAA−PS particles that can be solvent-cast to yield bulk films. For the multidentate nature of the PAA binding block, the PAA−PS coating is resistant toward solvent rinsing. The thickness of the coating can be increased by increasing the length of the PS block.
A Web Application for Glasses Virtual Try-on in 3D Space (2019)

Virtual try-on is a technology that allows people to virtually check the appearance of accessories, makeup, hairstyle, hair color, clothes and potentially more on themselves. The virtual try-on presents many advantages over real try-on, it speeds up the process providing the possibility to test hundreds of products without the need to reach a physical store. In this paper we propose a virtual try-on web application specific for eyeglasses and sunglasses that can be easily used by simply taking a picture of a face and selecting the desired frames. The try-on process is performed on a 3D face reconstructed from the input image allowing the user to see the virtual face and glasses from different viewpoints. The try-on process is fully automated and does not require the user to provide anything else but the picture and selection of the glasses frames to test.
Graded-band-gap <i>p</i>Ga1−<i>x</i>Al<i>x</i>As-<i>n</i>GaAs heterojunction solar cells (1975)

The theoretical spectral response of the graded-band-gap pGa1−xAlxAs-nGaAs solar cell is calculated by solving the continuity equations. The electric fields produce a collection efficiency two times larger than that of the abrupt heterojunction diodes at wavelengths less than 700 nm for surface recombination velocities of 106–107 cm/sec. The graded-band-gap diode can be operated at high frequencies because of the reduced transit time of minority carriers in the p-type layer. A graded-band-gap pGa1−xAlxAs-nGaAs solar cell is fabricated by utilizing the diffusion of Al in the Ga melt. The gradient of the energy gap is evaluated by photoresponse and photoluminescence measurements. The photoluminescence shows a broad emission peak from 700 to 800 nm at 77 K.
Ridaforolimus (AP23573; MK-8669), a Potent mTOR Inhibitor, Has Broad Antitumor Activity and Can Be Optimally Administered Using Intermittent Dosing Regimens (2011)

The mTOR pathway is hyperactivated through oncogenic transformation in many human malignancies. Ridaforolimus (AP23573; MK-8669) is a novel rapamycin analogue that selectively targets mTOR and is currently under clinical evaluation. In this study, we investigated the mechanistic basis for the antitumor activity of ridaforolimus in a range of human tumor types, exploring potential markers of response, and determining optimal dosing regimens to guide clinical studies. Administration of ridaforolimus to tumor cells in vitro elicited dose-dependent inhibition of mTOR activity with concomitant effects on cell growth and division. We showed that ridaforolimus exhibits a predominantly cytostatic mode of action, consistent with the findings for other mTOR inhibitors. Potent inhibitory effects on vascular endothelial growth factor secretion, endothelial cell growth, and glucose metabolism were also observed. Although PTEN and/or phosphorylated AKT status have been proposed as potential mTOR pathway biomarkers, neither was predictive for ridaforolimus responsiveness in the heterogeneous panel of cancer cell lines examined. In mouse models, robust antitumor activity was observed in human tumor xenografts using a series of intermittent dosing schedules, consistent with pharmacodynamic observations of mTOR pathway inhibition for at least 72 hours following dosing. Parallel skin-graft rejection studies established that intermittent dosing schedules lack the immunosuppressive effects seen with daily dosing. Overall these findings show the broad inhibitory effects of ridaforolimus on cell growth, division, metabolism, and angiogenesis, and support the use of intermittent dosing as a means to optimize antitumor activity while minimizing systemic effects.
A new concept of parallel robot for rehabilitation and fitness: The Lambda (2009)

A new rehabilitation and fitness robot called the “Lambda Robot” is presented. This paper introduces a concept of a parallel robot that may be used for mobilization of the lower extremities. Hence, it may be used for fitness as well as for rehabilitation for people out of coma, after a surgical operation or for paraplegics. The kinematics and the construction aspects of the twice three degrees of freedom “Lambda robot” are presented. The different configurations it deals with are discussed to point out the advantages of this structure. Finally, the control and security aspects are presented. The constructed prototype is entirely instrumented with position and force sensors at each motorized articulation. This allows controlling all the movements and the corresponding generated forces.
Analyzing the ripple effects of change in business process models (2013)

Change management is a critical task to control the side effects of a modification during the business process evolution. The evolution of business processes is an essential activity for the companies to better fulfill the requirements of their customers and different stakeholders. In this respect, the enterprises should adopt an effective mechanism in order to achieve the flexible business process models. It is important to identify and highlight the ripple effects of a change for minimizing their impact on other parts or entities of the system and associated services. This paper proposes a dependency-centric approach for change impact analysis. We attempt to demonstrate the change impact propagation in business process models by detecting and analyzing the interdependencies among all parts of business processes along with associated services. It can support the maintenance and evolution of business process models. The major objective is to help the modelers and business experts to assess the associated risk of intended changes and estimate the effort required for their accomplishments.
Pyridoxamine analogs. Absorption spectra and metal chelate formation in methonol. (1975)

The absorption spectra of salicylamine (ο-hydroxybenzylamine) (I), thiosalicylamine (ο-mercaptobenzylamine) (II), and 3-hydroxy-4-aminomethylpyridine (III), have been measured at various concentrations of added acid or alkali in methanol solution. Assignments of the absorption bands to the various molecular species are made. I existed as a nonpolar species, whereas II did as a dipolar species with a dissociated thiol group, in neutral methanol solutions. This was supported by the pKa values (I ; 9.2, 10.5 : II ; 4.7, 9.5) calculated from potentiometric titration curves in aqueous solutions. Both polar and nonpolar species were present in a neutral methanol solution of III. The Al [III], Cd [II], Ni [II] and Zn [II] chelates of II were fairly stable, whereas those of I were not formed appreciably, in methanol. III formed Al [III], Cd [II], Cu [II], Ni [II], and Zn [II] chelates, spectra of which were quite similar to those of metal chelates of pyridoxamine. Spectral change of a solution containing II and Cu [II] ion shows II formed Cu [II] chelate and, then, was converted to benzisothiazol. In the presence of Zn [II] ion, II and sodium pyruvate formed Zn [II] chelate of ketimine Schiff base, which underwent tautomerization to that of aldimine Schiff base very slowly. Possible correlation is noted between pKa's of the phenolic group of pyridoxamine and its analogs and their abilities to form metal chelates and to catalyze the nonenzymatic transamination.
Efficient distributed simulation (1989)

Discrete-event systems are used to model a number of engineering applications ranging from performance analysis of large scale communication networks, computer-aided-design (CAD) of circuits to simulation of manufacturing systems. Except for a small set, these systems are analytically intractable and in addition prohibitive to evaluate numerically. Simulation of such complex systems is exceedingly slow to run (and also to develop). Therefore, the development of simulation speedup methods is of crucial importance in its potential of making feasible the evaluation of a vastly larger set of engineering systems. New analytical models are proposed for the analysis of asynchronous, distributed simulation of discrete-event systems. Vectored distributed simulation and a new rollback algorithm, Wolf, are examined in this framework and comparison with existing systems is attempted. A number of examples illustrate the advantages to such a realization of distributed simulation. Implementation of our algorithms on a distributed computing system confirm analytical results predicting a considerable reduction in error propagation, and an enhancement in forward computation.
Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer (2016)

Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8<sup>+</sup> T-cell effector functions, such as cytokine and granzyme production, depend on cytoplasmic Ca<sup>2+</sup>, which is controlled by ion channels. In particular, Kv1.3 channels regulate the membrane potential and Ca<sup>2+</sup> influx in human effector memory T (T<sub>EM</sub>) cells. In this study, we assessed the contribution of reduced Kv1.3 and Ca<sup>2+</sup> flux on TIL effector function in head and neck cancer (HNC). We obtained tumor samples and matched peripheral blood from 14 patients with HNC. CD3<sup>+</sup> TILs were composed of 57% CD4<sup>+</sup> (82% T<sub>EM</sub> and 20% Tregs) and 36% CD8<sup>+</sup> cells. Electrophysiology revealed a 70% reduction in functional Kv1.3 channels in TILs as compared with peripheral blood T cells from paired patients, which was accompanied by a decrease in Ca<sup>2+</sup> influx. Immunofluorescence analysis showed that CD8<sup>+</sup> TILs expressing high Kv1.3 preferentially localized in the stroma. Importantly, high expression of Kv1.3 correlated with high Ki-67 and granzyme B expression. Overall, these data indicate that defective Kv1.3 channels and Ca<sup>2+</sup> fluxes in TILs may contribute to reduced immune surveillance in HNC. Cancer Res; 77(1); 53-61. ©2016 AACR.
A Molecular Dynamics Study of Aggregation Phenomena in Aqueous <i>n</i>-Propanol (2004)

Low-frequency Raman studies of various concentrations of aqueous n-propanol at room temperature indicate that both water and n-propanol form single-component aggregates in solution. Small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS) studies also provide evidence of this tendency toward aggregation. Molecular dynamics simulations of 16% aqueous n-propanol, a concentration for which maximum segregation of n-propanol and water is observed, have been carried out in an attempt to elucidate the structure of these aggregates. Kirkwood−Buff integrals calculated from the radial distribution functions of the components show excellent agreement with experimentally derived values. Analysis of the atomic coordinates from the simulations reveal that approximately 50% of the n-propanol molecules are members of homogeneous hydrogen-bonded chains of up to 16 members in length, the majority of which are dimers. The g(r) data also indicate that a strong hydrophobic association exists between the hydrocarbon tails. This hydrophobic association is independent of hydrogen-bonding state, and results in the formation of an approximately 10-member micelle structure centered around the n-propanol chains. Water is excluded from the regions occupied by the n-propanol micelles. The water structure is largely unaffected except for a small amount of disruption at the interface between the bulk solvent and the n-propanol clusters, and the formation of small water clusters at the interface with the bulklike solvent that interact with hydroxyl groups at the ends of the propanol chains.
Determination of glomerular size-selectivity in the normal rat with Ficoll. (1992)

Diffusion studies in vitro indicate that Ficoll behaves more like an ideal spherical molecule than does dextran, suggesting that Ficoll would be a better probe of glomerular pore size than the commonly used dextran. To examine the differences between these macromolecules in vivo, the fractional clearances of tritiated Ficoll and dextran were measured over a wide range of molecular sizes (Stokes-Einstein radius, rs, from 19 to 65 A) in normal euvolemic Munich-Wistar rats. Whole-kidney and single-nephron hemodynamic conditions were characterized through a combination of clearance and micropuncture measurements. The fractional clearance, or sieving coefficient (theta), for dextran significantly exceeded that of Ficoll at all molecular sizes examined, theta for dextran being approximately 10 times that for Ficoll for rs greater than 30 A. Thus, the results with Ficoll imply a more size-restrictive barrier than do the results with dextran. The values of theta for Ficoll approximated previously reported values for uncharged globular proteins. Although theta for Ficoll at rs = 35 A was much smaller than the corresponding value for dextran, it was still approximately 30 times greater than typical values of the filtrate-to-plasma concentration ratio reported for serum albumin (a polyanion) in the rat, in agreement with the concept that glomerular charge-selectivity normally plays an important role in the prevention of albuminuria. Three membrane-pore models were compared in their ability to represent the dextran and Ficoll sieving data. A lognormal pore-size distribution in parallel with a nonselective "shunt" pathway was found to be more effective than either an isoporous membrane with a shunt or a purely lognormal distribution. On the basis of these laboratory results and computations, Ficoll may be preferred over dextran in future studies of glomerular size-selectivity.
Nitric Oxide is Produced by<i>Cowdria ruminantium</i>-Infected Bovine Pulmonary Endothelial Cells In Vitro and Is Stimulated by Gamma Interferon (1998)

Nitric oxide (NO) is a labile inorganic free radical produced by NO synthase from the substrate L-arginine in various cells and tissues including endothelial cells. A substantial elevation of nitrite levels indicative of NO production occurred in cultures of Cowdria ruminantium-infected bovine pulmonary endothelial cells (BPEC) incubated in medium alone. Exposure of the infected cultures to recombinant bovine gamma interferon (BorIFN-gamma) resulted in more rapid production of NO, reduced viability of C. ruminantium, and induction of endothelial cell death. Significant inhibition of NO production was noted after addition of the NO synthase inhibitor N-monomethyl-L-arginine (L-NMMA), indicating that the increase in production occurred via the inducible NO synthase pathway. Reduction in the infectivity of C. ruminantium elementary bodies (EBs) occurred in a dose-dependent manner after incubation with the NO donor molecule S-nitroso-N-acetyl-DL-penicillamine (SNAP) prior to infection of endothelial cells. The level of infection in cultures maintained in SNAP was reduced in a dose-dependent manner with significant negative correlation between the final level of infection on day 7 and the level of SNAP (r = -0.96). It was established that pretreatment and cultivation of C. ruminantium EBs with the NO donor molecule SNAP reduced infectivity to cultures and viability of EBs with the implication that release of NO in vivo following infection of endothelial cells may have an effect upon the multiplication of the agent in the host animal and may be involved in the pathogenesis of heartwater through the effect of this molecule upon circulation.
STRBase: a short tandem repeat DNA database for the human identity testing community (2001)

The National Institute of Standards and Technology (NIST) has compiled and maintained a Short Tandem Repeat DNA Internet Database (http://www.cstl.nist.gov/biotech/++ +strbase/) since 1997 commonly referred to as STRBase. This database is an information resource for the forensic DNA typing community with details on commonly used short tandem repeat (STR) DNA markers. STRBase consolidates and organizes the abundant literature on this subject to facilitate on-going efforts in DNA typing. Observed alleles and annotated sequence for each STR locus are described along with a review of STR analysis technologies. Additionally, commercially available STR multiplex kits are described, published polymerase chain reaction (PCR) primer sequences are reported, and validation studies conducted by a number of forensic laboratories are listed. To supplement the technical information, addresses for scientists and hyperlinks to organizations working in this area are available, along with the comprehensive reference list of over 1300 publications on STRs used for DNA typing purposes.
Lateral prediction of reservoir properties using seismic attributes with well log data (1992)

Seismic attributes are mathematical transformations of seismic data, typically dove after stacking and imaging (Taner et al, 1979) . Examples are amplitude, instantaneous frequency, P and S velocities, band-limited impedance, apparent dip or azimuth, and others . Rock or petrophysical propertjes (e .g ., porosity, Poisson's ratio, relative shale volume, fluid content, and others) describe the medium itself, and are measured or computed in situ from logs. Seismic attributes carry the promise of indicating such real propertjes, since in some circumstances certain attributes can be expected to correlate highly with specific rock properties (Sonneland et al, 1990)
Genetic variants in SLC9A9 are associated with measures of Attention-deficit/hyperactivity disorder symptoms in families (2010)

Our results suggest that SLC9A9 may be related to hyperactive-impulsive symptoms in AD/HD and the disruption of SLC9A9 may be responsible for the behavioral phenotype observed in the inversion family. The association with SLC9A9 is particularly interesting as it was recently implicated in a genome-wide association study for AD/HD. Further investigation of the role of SLC9A9 in AD/HD and other behavioral disorders is warranted.
Polymer Dielectrics for 3D‐Printed RF Devices in the <i>K</i><sub>a</sub> Band (2016)

Direct-write printing allows the fabrication of centimeter-wave radio devices. Most polymer dielectric polymer materials become lossy at frequencies above 10 GHz. Presented here is a printable dielectric material with low loss in the K a band (26.5–40 GHz). This process allows the fabrication of resonator filter devices and a radio antenna. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Large Format Fabrication a Practical Approach to Low Cost MCM-D (2005)

The IBM Microelectronics Division at East Fishkill has recently demonstrated the fabrication of thin films for MCM-D on large area panels, 300 mm x 300 mm in size. Fabrication of the thin films was accomplished on IBM's 300 mm development Line using immersion development of photosensitive polyimide for via formation and electrolytic plating to define wiring and terminal metal Levels. One plane pair of thin films was constructed on Corning glass 7059 panels for 35 micron Lines on 85 micron pitch. In addition, two metal - dielectric Levels with 13 um lines on 25 um pitch has also been demonstrated. The 25 um pitch represents the most aggressive groundrule practiced in electronic packaging today. The successful production of electrically good substrates at a high yield from a 300 mm panel provides a gateway to significant cost reductions of future MCM-D products from IBM. In this paper we will discuss the processes and equipment used to fabricate two different test vehicles, as welt as some of cost and yield considerations associated with Large area panel processing for MCM-D packages.
Atomic Structure of Clean Si(113) Surfaces: Theory and Experiment (1994)

High-index surfaces of Si are of potential technological interest but they tend to facet into low-index planes. The only known exception is Si(113) with a surface energy about as small as Si(001); however, its atomic structure remained unresolved. On the basis of scanning tunneling microscopy measurements and ab initio theory we present a new atomic model of Si(113) employing a novel idea of a subsurface self-interstitial. The calculated surface energy of Si(113) (3 \ifmmode\times\else\texttimes\fi{} 2) is close to the value for Si(001)-$p(2\ifmmode\times\else\texttimes\fi{}2)$. The new model explains experimentally observed transitions between the 3 \ifmmode\times\else\texttimes\fi{} 1 and 3 \ifmmode\times\else\texttimes\fi{} 2 phases.
Bridgeless buck PFC rectifier (2010)

A new bridgeless buck PFC rectifier that substantially improves efficiency at low line of the universal line range is introduced. By eliminating input bridge diodes, the proposed rectifier's efficiency is further improved. Moreover, the rectifier doubles its output voltage, which extends useable energy of the bulk capacitor after a drop-out of the line voltage. The operation and performance of the proposed circuit was verified on a 700-W, universal-line experimental prototype operating at 65 kHz. The measured efficiencies at 50% load from 115-V and 230-V line are both close to 96.4%. The efficiency difference between low line and high line is less than 0.5% at full load. A second-stage half-bridge converter was also included to show that the combined power stages easily meet Climate Saver Computing Initiative Gold Standard.
Jurisdicción municipal e instancias reales en la Valencia moderna. Una aproximación desde las Decisiones de Francisco Jerónimo de León (2017)

The aim of this paper is to study the relationship between municipal jurisdiction and royal power in the kingdom of Valencia proposed by the jurist Francisco Jerónimo de León at the beginning of the 17th century. We analyze the different ways of regal intervention, concerning mechanisms of configuration of the ruling groups as well as the control of municipal tax authorities in some spheres of municipal power that the magistrate justified in his legal work.
Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction (2012)

These findings indicate that in type 1 diabetic mice the myocardial Shh pathway is impaired and that the impaired Shh pathway contributes to cardiac dysfunction. Strategies that are aimed at augmenting the Shh pathway may offer useful means for improving diabetic cardiac dysfunction.