gebhart/patrepeval huggingface dataset:
Nap1-mediated actin remodeling is essential for mammalian myoblast fusion (2009)

Myoblast fusion is crucial for the formation, growth, maintenance and regeneration of healthy skeletal muscle. Unfortunately, the molecular machinery, cell behaviors, and membrane and cytoskeletal remodeling events that govern fusion and myofiber formation remain poorly understood. Using time-lapse imaging approaches on mouse C2C12 myoblasts, we identify discrete and specific molecular events at myoblast membranes during fusion and myotube formation. These events include rearrangement of cell shape from fibroblast to spindle-like morphologies, changes in lamellipodial and filopodial extensions during different periods of differentiation, and changes in membrane alignment and organization during fusion. We find that actin-cytoskeleton remodeling is crucial for these events: pharmacological inhibition of F-actin polymerization leads to decreased lamellipodial and filopodial extensions and to reduced myoblast fusion. Additionally, shRNA-mediated inhibition of Nap1, a member of the WAVE actin-remodeling complex, results in accumulations of F-actin structures at the plasma membrane that are concomitant with a decrease in myoblast fusion. Our data highlight distinct and essential roles for actin cytoskeleton remodeling during mammalian myoblast fusion, provide a platform for cellular and molecular dissection of the fusion process, and suggest a functional conservation of Nap1-regulated actin-cytoskeleton remodeling during myoblast fusion between mammals and Drosophila.
Calorimetric Markers of Bence Jones and Nonsecretory Multiple Myeloma Serum Proteome (2014)

The present work provides a thermodynamic description of blood serum from patients diagnosed with Bence Jones myeloma (BJMM) and nonsecretory myeloma (NSMM) by means of differential scanning calorimetry (DSC), serum protein electrophoresis, and free light chain assay. Specific alterations in the thermodynamic behavior of both BJMM and NSMM proteome have been revealed. On the basis of the transition temperature of the main transition in the calorimetric profiles and the shape similarity criterion, we defined BJMM and NSMM sets/subsets of thermograms with very similar thermodynamic features. We show that some of the BJMM and NSMM subsets correlate with previously defined secretory myeloma subsets (Todinova et al. Anal. Chem. 2011, 83, 7992). The established analogies strongly suggest that common molecular markers contribute to the calorimetric profiles of the different, secretory and nonsecretory, myeloma types; our data show robust evidence that these are ligands stabilizing the major serum proteins. We demonstrate that the DSC approach might be highly beneficial, especially for NSMM patients, since the characteristic modifications in the DSC profiles might serve as calorimetric markers when no monoclonal proteins can be detected in the bloodstream and the diagnosis heavily relies on invasive methods.
Bistatic radar using satellite-borne illuminators (2003)

Bistatic radar has long been recognised as an interesting variant of radar, with a number of potential advantages for air defence. Space-based radar is seen by the US Department of Defense as a key technique for future AMTI and GMTI applications, and the DISCOVERER II programme is indicative of current thinking, aiming ultimately at a network of several tens of satellites. This system would also involve bistatic receivers to give near-continuous surveillance. The purpose of this paper is to present a system concept for a bistatic radar using a satellite-based illuminator of opportunity and a static ground-based receiver. The paper presents system design and performance calculations, and describes experiments to be performed.
Cold Light Source for Endoscopy using AVR Microcontroller (2014)

An endoscopy involves the procedure of examining internal organs of the human body  using endoscope. Presently, during endoscopy halogentype or xenon type light sources  are used. The main drawback of these sources is the heat dissipated by them effects the  sensor data. Due to high temperature in the surrounding environment, the video tube  or optical fiber used to transfer data may be damaged. Moreover if the lamp turns off  during operation, one cannot change it immediately because of its high temperature. Thus the redundancy of the system is less. In order to overcome these limitations the  halogen and the xenon light are replace by LED which is a cold light source. Since the  LED is operated on DC source, the driver circuit would replace the bulky transformers  used to operate halogen/xenon lamps. This reduces the weightand cost of the  equipment. LED has longer life and it provides the better efficiency compared to the  former devices. It also eliminates the use of cooling fan which is used for heat sinking  purpose. In the proposed instrument, intensity of LED light and its life will be  displayed with the use of micro controller. Keywords: Drive circuit , LED light , light focusing , optical principle , temperature control  & light control using AVR micro controller , data logger
A Model for Encoding Multiple Object Motions and Self-Motion in Area MST of Primate Visual Cortex (1998)

Many cells in the dorsal part of the medial superior temporal (MST) region of visual cortex respond selectively to specific combinations of expansion/contraction, translation, and rotation motions. Previous investigators have suggested that these cells may respond selectively to the flow fields generated by self-motion of an observer. These patterns can also be generated by the relative motion between an observer and a particular object. We explored a neurally constrained model based on the hypothesis that neurons in MST partially segment the motion fields generated by several independently moving objects. Inputs to the model were generated from sequences of ray-traced images that simulated realistic motion situations, combining observer motion, eye movements, and independent object motions. The input representation was based on the response properties of neurons in the middle temporal area (MT), which provides the primary input to area MST. After applying an unsupervised optimization technique, the units became tuned to patterns signaling coherent motion, matching many of the known properties of MST cells. The results of this model are consistent with recent studies indicating that MST cells primarily encode information concerning the relative three-dimensional motion between objects and the observer.
Towards integrated analysis of longitudinal whole-body small animal imaging studies (2011)

This paper discusses a number of image analysis challenges emerging from longitudinal small animal molecular imaging studies. Three steps towards a quantitative 3D analysis of follow-up small animal imaging are presented: whole-body articulated registration, change visualization in follow-up data and fusion of optical and 3D structural imaging data. Several application examples are presented in the context of translational cancer research.
A high-performance complementary inverter based on transition metal dichalcogenide field-effect transistors (2015)

For several years, graphene has been the focus of much attention due to its peculiar characteristics, and it is now considered to be a representative 2-dimensional (2D) material. Even though many research groups have studied on the graphene, its intrinsic nature of a zero band-gap, limits its use in practical applications, particularly in logic circuits. Recently, transition metal dichalcogenides (TMDs), which are another type of 2D material, have drawn attention due to the advantage of having a sizable band-gap and a high mobility. Here, we report on the design of a complementary inverter, one of the most basic logic elements, which is based on a MoS2 n-type transistor and a WSe2 p-type transistor. The advantages provided by the complementary metal-oxide-semiconductor (CMOS) configuration and the high-performance TMD channels allow us to fabricate a TMD complementary inverter that has a high-gain of 13.7. This work demonstrates the operation of the MoS2 n-FET and WSe2 p-FET on the same substrate, and the electrical performance of the CMOS inverter, which is based on a different driving current, is also measured.
LA FALTA DE CONFIANZA EN LA POLICIA, UNO DE LOS PROBLEMAS DE SEGURIDAD PUBLICA (1996)

AL DICTAR CONFERENCIA LA SEGURIDAD PUBLICA EN EL DISTRITO FEDERAL EN EL AUDITORIO THEMIS DE FACULTAD DE DERECHO (FD), FRANCISCO PONCE GOMEZ, MAGISTRADO DEL TRIBUNAL CONTENCIOSO ADMINISTRATIVO DEL DISTRITO FEDERAL, SENALO QUE UNO DE LOS PRINCIPALES PROBLEMAS DE SEGURIDAD PUBLICA ESTA RELACIONADO CON FALTA DE CREDIBILIDAD DE LOS CUERPOS POLICIACOS. POR OTRA PARTE, DURANTE CLAUSURA DE SEGUNDA SEMANA DE SEGURIDAD, RAFAEL CORDERA CAMPOS, SECRETARIO DE ASUNTOS ESTUDIANTILES DE UNAM, PRECISO QUE EL INTERCAMBIO DE CONOCIMIENTOS PROPORCIONADO A TRAVES DE REALIZACION DE ESTE EVENTO PERMITIO QUE LOS UNIVERSITARIOS SE PLANTEARAN NUEVAS METAS PARA CONTRIBUIR A PROFESIONALIZACION DE LOS SERVICIOS DE SEGURIDAD UNIVERSITARIOS. EL EVENTO CONTO CON PARTICIPACION Y ASISTENCIA DEL TITULAR DE DIRECCION DE PROTECCION A COMUNIDAD, JORGE MENDEZ DUARTE; JUAN MANUEL MICHER CAMARENA, DIRECTOR GENERAL DE SERVICIOS MEDICOS; LUIS CACERES ALVARADO, DIRECTOR DE ACTIVIDADES DEPORTIVAS Y RECREATIVAS; JOSE LUIS VICTORIA TOSCANO, DIRECTOR GENERAL DE APOYO Y SERVICIOS A COMUNIDAD Y FRANCISCO GOMEZ RUIZ, DIRECTOR GENERAL DE SERVICIO SOCIAL MULTIDISCIPLINARIO.
Fast flip-flop of cholesterol and fatty acids in membranes: implications for membrane transport proteins (2003)

Knowledge of these properties provides a framework for understanding transport and metabolism of cholesterol and fatty acids and how their putative membrane and intracellular transporters might function.
Estimating spectral reflectance from camera responses based on <scp>CIE</scp><scp><i>XYZ</i></scp> tristimulus values under multi‐illuminants (2016)

Abstract A new spectral reflectance estimation method based on CIE XYZ values under multi‐illuminants was proposed to obtain multi‐spectral images accurately by using digital still cameras. CIE XYZ values under multi‐illuminants were initially predicted from raw RGB responses by using a polynomial model with local training samples. Then, spectral reflectance was constructed from the predicted CIE XYZ values via the pseudo‐inverse method. Experimental results indicated that the new spectral reflectance estimation method significantly outperformed the traditional colorimetric characterization method without requiring extra training samples or greatly increasing computational complexities. © 2016 Wiley Periodicals, Inc. Col Res Appl, 42, 68–77, 2017
Angiotensin II sustains brain inflammation in mice via TGF-β (2010)

The renin-angiotensin-aldosterone system (RAAS) is a key hormonal system regulating blood pressure. However, expression of RAAS components has recently been detected in immune cells, and the RAAS has been implicated in several mouse models of autoimmune disease. Here, we have identified Ang II as a paracrine mediator, sustaining inflammation in the CNS in the EAE mouse model of MS via TGF-beta. Ang II type 1 receptors (AT1Rs) were found to be primarily expressed in CNS-resident cells during EAE. In vitro, astrocytes and microglia responded to Ang II treatment by inducing TGF-beta expression via a pathway involving the TGF-beta-activating protease thrombospondin-1 (TSP-1). TGF-beta upregulation in astrocytes and microglia during EAE was blocked with candesartan (CA), an inhibitor of AT1R. Treatment of EAE with CA ameliorated paralysis and blunted lymphocyte infiltration into the CNS, outcomes that were also seen with genetic ablation of AT1Ra and treatment with an inhibitor of TSP-1. These data suggest that AT1R antagonists, frequently prescribed as antihypertensives, may be useful to interrupt this proinflammatory, CNS-specific pathway in individuals with MS.
PathMiner: predicting metabolic pathways by heuristic search (2003)

We build a biochemical state-space using data from known enzyme-catalyzed transformations in Ligand, including, 2917 unique transformations between 3890 different compounds. To predict metabolic pathways we explore this state-space by developing an informed search algorithm. For this purpose we develop a chemically motivated heuristic to guide the search. Since the algorithm does not depend on predefined pathways, it can efficiently identify plausible routes using known biochemical transformations.
Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts (2003)

Comparing lymphocyte responses to allergenic and nonallergenic foods could reveal the differences between pathogenic and normal immune responses to foods. Defining the cytokine-producing phenotypes of peanut-specific lymphocytes from peanut-allergic children, children who outgrew peanut allergy, and children who have always tolerated peanuts may be useful for understanding the mechanisms of food tolerance. Investigating immune responses against foods is hindered, however, by the fact that circulating food antigen-specific lymphocytes are very rare. In a novel approach we used carboxyfluorescein succinimidyl ester to detect peanut-specific lymphocytes by flow cytometry. We confirmed that these cells are indeed peanut specific by cloning. Peanut-allergic donors show Th2 polarization of cytokine production by peanut-specific cells (IFN-gamma (low), TNF-alpha (low), IL-4 (high), IL-5 (high), IL-13 (high)). Conversely, nonallergic children and children who have outgrown their allergy show Th1 skewing to peanut antigens (IFN-gamma(high), TNF-alpha (high), IL-4 (low), IL-5 (low), IL-13(low)), similarly to nonallergenic food antigens (beta-lactoglobulin, OVA). This finding suggests that peanut antigens do not intrinsically induce Th2 skewing, but that the type of response depends upon the donor's allergic status. In conclusion, food allergic status is characterized by a Th2 response whereas Th1-skewed responses underlie oral tolerance.
Optical Lattice Polarization Effects on Hyperpolarizability of Atomic Clock Transitions (2006)

The light-induced frequency shift due to hyperpolarizability (i.e., terms of second-order in intensity) is studied for a forbidden optical transition, J = 0 --> J = 0. A simple universal dependence on the field ellipticity is obtained. This result allows minimization of the second-order light shift with respect to the field polarization for optical lattices operating at a magic wavelength (at which the first-order shift vanishes). We show the possibility for the existence of a magic elliptical polarization, for which the second-order frequency shift vanishes. The optimal polarization of the lattice field can be either linear, circular, or magic elliptical. The obtained results could improve the accuracy of lattice-based atomic clocks.
From nanocomposite to nanogel polymer electrolytes (2002)

This review discusses recent advances in polymer electrolyte nanocomposites. In particular, we highlight our recent understanding on the structure and dynamics at the polymer/nanoparticle interface and attempt to correlate to macroscopic properties. We also discuss our current effort on nanogel electrolytes synthesized by incorporating layered nanoparticles into a gel. The nanogel electrolytes combine the high ambient conductivity of conventional gel electrolytes with the excellent stability toward the metal electrode and the good mechanical properties of nanocomposite electrolytes.
The Development of the Flexible-Disk Magnetic Recorder (1961)

A brief history of the development of the flexible-disk magnetic recorder is presented. Principles of the aeroelastic behavior of the disk and the results of a mathematical analysis of the equilibrium operating conditions are discussed. Experimental results are given which illustrate the effects of operating parameters on disk dynamics. These results indicate the design considerations necessary to produce a wide range of new storage devices. The characteristics of some of the newly developed models are presented.
Copper Wires for High Speed Logic LSI Prepared by Low Pressure Long Throw Sputtering Method (2002)

Copper sputtering method for fabrication of high performance logic LSI was studied. Extension of target to substrate distance is effective to improve step coverage of sputtered film combined with reduced operation pressure. Step coverage of low pressure long throw sputtering method also strongly depends upon the feature size of trenches and holes which are formed on silicon wafer. Sub-micron holes and trenches are successfully filled with copper by using this sputtering process followed by re-flow annealing process. Hydrogen annealing process prior to the sputtering deposition on via openings is also investigated to realize good conductivity through the via. This process results in the reduction of copper oxide at the surface of copper film. Using these newly developed processes, 0.2 \\micron node BiCMOS LSI with 4 level copper interconnects was successfully fabricated and high performance of the copper interconnect system was clearly demonstrated.
A wavelength-versatile, continuous-wave, self-Raman solid-state laser operating in the visible (2010)

We report a continuous-wave Nd:GdVO(4) self-Raman laser generating wavelength-selectable output in the green-yellow spectral region. The laser combines stimulated Raman scattering (SRS) with intracavity second harmonic and sum-frequency generation (SHG/SFG) to enable "on-demand" operation at any one of three wavelengths, 532 nm, 559 nm and 586 nm, each with output power greater than 3.5 W. Using experimental and numerical modelling results, we show how the highly-interactive, simultaneous non-linear processes of SRS and SHG/SFG may be balanced to achieve stable, selectable multi-wavelength visible operation.
A simultaneous receiving multi-band mixer with independent gain control (2011)

A multi-band mixer that can receive multiple band signals simultaneously is proposed. Using multiple local oscillator (LO) signals simultaneously, the mixer achieves independent gain control through relative power control of the multiple LO signals. Linear gain control is also achieved through multiple LO signal input with total LO power control. Theoretical analysis shows that a third-order nonlinearity component of the multiple LO signals supports linear conversion gain control. The measured test performances of a dual band receiving at the 300 MHz and 2.4 GHz bands supports the results of the theoretical analysis. Tests were conducted using a commercial double-balanced diode mixer and an MOSFET mixer we fabricated. Measurements confirm that linear control and independent control of conversion gain are achieved.
CREATING AN IPHONE APPLICATION FOR COLLECTING CONTINUOUS ABC DATA (2012)

This paper provides an overview and task analysis for creating a continuous ABC data-collection application using Xcode on a Mac computer. Behavior analysts can program an ABC data collection system, complete with a customized list of target clients, antecedents, behaviors, and consequences to be recorded, and have the data automatically sent to an e-mail account after observations have concluded. Further suggestions are provided to customize the ABC data- collection system for individual preferences and clinical needs.
A business process design method for applying workflow tools-using the concept of business process design pattern (2002)

Focuses on the collaboration in the business process, and proposes the design methodology to develop the flexible business process, which easily follows various status changes. A new concept "business process design pattern": which is based on the language/action perspective, is introduced. The business process design pattern is the basic structure for the target business independent of the problem change. By means of this methodology, the business process reengineering can be executed step by step according to the problem change toward the final goal, and in case of the routine process, the design pattern can be shared among many departments and corporations.
Pruneyard Shopping Center v. Robins: Past, Present and Future (1981)

The United States Supreme Court's decision last term in Prune-Yard Shopping Center v. Robins' represents the latest tack in the zigzag path taken by the Court in seeking to reconcile conflicting free speech and private property claims.Since 1968, in numerous varied situations, 2 the Court has sought to chart this heretofore largely unexplored area.Unfortunately, despite this repeated examination, the waters remain murky and the future course far from certain.To explore both the wisdom of the new direction now suggested by PruneYard, and the potential resolution of the questions left unanswered by that opinion, this article will first examine PruneYard's past and present.
Micropatternable multifunctional nanocomposite polymers for flexible soft MEMS applications (2011)

This thesis describes the fabrication, micro-machining, and characterization of novel multifunctional nanocomposite polymers for flexible microsystems.Various elastomers, primarily polydimethylsiloxane (PDMS), a silicone based elastomer, are chosen as substrate materials to create new flexible microsystems because of numerous benefits of PDMS including flexibility, biocompatibility, low cost, low toxicity, high oxidative and thermal stability, optical transparency, low permeability to water, low electrical conductivity, and ease of micropatterning. However, most devices to date based on PDMS are passive, as making active devices out of PDMS is extremely challenging.When PDMS is bonded to substrates with conventionally-realized active components like electrodes, heaters, sensors, actuators, etc., it is rendered inflexible – defeating one of its key benefits. For example, the common method of bonding PDMS with glass renders the resulting devices completely inflexible.If metals or alloys are deposited on PDMS, the weak adhesion between them and PDMS leads to microcracks when the substrates are flexed,bent,or twisted.This leads to electrical disconnection and device failure.The focus of this thesis is the development of novel approaches to the realization of active-component based highly flexible microsystems employing PDMS and/or other elastomer materials.To overcome problems with incorporating active devices while maintaining system flexibility, various new materials and methods of microfabricating them are developed.These newly developed electrically conductive and magnetic nanocomposite polymers deliver flexibility similar to undoped and insulating PDMS, yet provide functionality for active device development similar to the inclusion of inflexible metals and other functional materials.These new polymers can also be easily micromicromolded using conventional PDMS processing, such as soft lithography techniques. A new hybrid microfabrication process for combining micromolded nanocomposite with undoped PDMS polymer is also developed to demonstrate the potential of the new polymers to be incorporated into fully flexible systems containing active components. Poly(methyl methacrylate) (PMMA) is also explored as a new molding substrate for small and large area microfabrication. Applications of these multifunctional nanocomposites include shape-conformable microelectrodes, hard magnetic microactuators, signal routing for Lab on a Chip (LOC) and many other devices requiring flexible microsystems and electronics.