gebhart/patrepeval huggingface dataset:
Regulation of human cytotoxic T lymphocyte development by IL-7. (1990)

The effects of IL-7 on the generation of human CTL in alloantigen-, virus-, and lectin-stimulated systems were examined. Addition of IL-7 at the onset of cultures resulted in marked (up to 80-fold) augmentation of cytotoxicity accompanied by smaller (1.5- to 4-fold) increases in total lymphocyte number. Studies of CTL development in purified lectin-stimulated CD8+ T cell populations demonstrated that IL-7 could act directly on the CD8+ lymphocyte subset to augment cytotoxicity. In MLC, the IL-7-induced enhancement of cytotoxicity was found to be mediated primarily by the CD8+ subpopulation of lymphocytes. Late addition of IL-7 (day 5 of 7) resulted in an increase in cytolytic activity that was associated with little or no increase in total or activated CD8+ lymphocyte number indicating that IL-7 may act as a differentiation factor for human CTL. A role for endogenous IL-7 in CTL development was suggested by the observation that addition of neutralizing antiserum to IL-7 to MLC at initiation (or 5 days thereafter) resulted in decreased levels of cytotoxicity. These results indicate that IL-7 can exert major up-regulatory effects on human CTL development and suggest that these effects are both proliferative and differentiative.
A simple method for estimating average number of nucleotide substitutions within and between populations from restriction data. (1990)

A simple method is proposed for estimating the average number of nucleotide substitutions per site within and between populations for the case where a large number of individuals are examined for many restriction enzymes. This method gives essentially the same results as those obtained by Nei and Li's method but saves a large amount of computer time. The variances of the quantities estimated can be obtained by the jackknife method, and these variances are very similar to those obtained by Nei and Jin's more sophisticated method. A similar method can also be applied to DNA sequence data.
Methotrexate shows benefit in a subset of patients with severe hidradenitis suppurativa (2020)

Methotrexate may represent an effective treatment option in older patients with lower body mass indices but fails to offer benefit in patients taking concurrent biologic therapy.
MONTE CARLO CHARACTERIZATION OF PRESSURIZED WATER REACTOR SPENT FUEL ASSEMBLY FOR THE DEVELOPMENT OF A NEW INSTRUMENT FOR PIN DIVERSION DETECTION (2006)

A novel concept to detect pin-diversion from spent fuel assembly is proposed and described. The instrument will use multiple tiny neutron and gamma detectors in a form of cluster (detector cluster) and high precision driving system to collect radiation signatures inside pressurized water reactor (PWR) assembly. In order to validate our concept, a Monte Carlo study was done using a Monte Carlo code MCNP5. MONTEBURNS, a computational tool that links MCNP and ORIGEN, was used to produce accurate PWR spent fuel isotopic compositions. Monte Carlo simulations, using realistic fuel geometry and actual fuel material information, were performed to study radiation field inside a PWR spent fuel assembly. The preliminary Monte Carlo simulation study shows that indeed 2 dimensional neutron data, when obtained in the presence of missing pins, have data profiles distinctly different from the profiles obtained without missing pins.
Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle‐mediated hyperthermia with low Curie temperature (2009)

Heat shock protein (Hsp) 90 is a key regulator of a variety of oncogene products and cell-signaling molecules, and the therapeutic benefit of its inhibition in combination with radiation or chemotherapy has been investigated. In addition, hyperthermia has been used for many years to treat various malignant tumors. We previously described a system in which hyperthermia was induced using thermosensitive ferromagnetic particles (FMP) with a Curie temperature (Tc = 43 degrees C) low enough to mediate automatic temperature control, and demonstrated its antitumor effect in a mouse melanoma model. In the present study, we examined the antitumor effects of combining a Hsp90 inhibitor (geldanamycin; GA) with FMP-mediated hyperthermia. In cultured B16 melanoma cells, GA exerted an antitumor effect by increasing the cells' susceptibility to hyperthermia and reducing expression of Akt. In an in vivo study, melanoma cells were subcutaneously injected into the backs of C57BL/6 mice. FMP were then injected into the resultant tumors, and the mice were divided into four groups: group I, no treatment (control); group II, one hyperthermia treatment; group III, GA alone; and group IV, GA with hyperthermia. When exposed to a magnetic field, the temperature of tissues containing FMP increased and stabilized at the Tc. In group IV, complete regression of tumors was observed in five of nine mice (56%), whereas no tumor regression was seen in groups I-III. Our findings suggest that inhibition of Hsp90 with hyperthermia increases its antitumor effect. Thus, the combination of FMP-mediated, self-regulating hyperthermia with Hsp90 inhibition has important implications for the treatment of cancer.
Chlamydia pneumoniae (TWAR) in coronary arteries of young adults (15-34 years old). (1995)

An association of Chlamydia pneumoniae with atherosclerosis of coronary and carotid arteries and aorta has been found by seroepidemiology and by demonstration of the organism in atheromata. Age-matched control tissue from persons without atherosclerosis was usually not available. We studied autopsy tissue from young persons, many with no atherosclerosis, to determine whether C. pneumoniae is present in atheroma in young persons with early atherosclerosis and to compare the findings in age- and sex-matched persons without atherosclerosis. A left anterior descending coronary artery sample, formalin-fixed, from 49 subjects, 15-34 years of age, from the multicenter study called Pathobiological Determinants of Atherosclerosis in Youth (PDAY), was examined by immunocytochemistry and the polymerase chain reaction (PCR) for the presence of C. pneumoniae and by PCR for cytomegalovirus. A hematoxylin/eosin-stained section was used to determine disease present in the studied sample. Seven of the artery samples were found to have atheromatous plaque, 11 had intimal thickening, and 31 had no lesions. Eight of the samples were positive for C. pneumoniae by immunocytochemistry (n = 7) and/or PCR (n = 3). Six of the 7 (86%) atheroma, 2 of the 11 (18%) with intimal thickening, and none of the 31 normal-appearing coronary samples were positive. Four were positive by PCR for cytomegalovirus, 2 from diseased arteries and 2 from normal arteries. Examination of the adjacent left coronary artery sample with a fat stain found abnormalities in 25 of the patients, but 19 still showed no evidence of atherosclerosis as a result of either examination. Thus, C. pneumoniae is found in coronary lesions in young adults with atherosclerosis but is not found in normal-appearing coronary arteries of both persons with and without other evidence of atherosclerosis.
Conflation System MBP. (2003)

MBPConflate is proof-of-concept software developed to aid in conflation research. The program implements a powerful algorithm for automatic multi-source image conflation that utilizes new Algebraic Systems-based similarity metrics during the feature comparison process. One benefit of integrating Algebraic Systems into the feature comparison process is that more global shape properties can be discovered, preserved, and used for matching. The algorithm presented in this paper clusters the individual attributes from two data sets based on connectivity and neighboring features. The clustered sets are then compared using a heirarchial rule-based technique that includes measures of structural similarity. User selected criteria define a match between features and the user assists feature matching only when ambiguity cannot be resolved automatically. Experiments have shown that the algorithm is computationally efficient and robust.
A text-independent speaker verification system using support vector machines classifier (2001)

Abstract In the recent years the technology for speaker verification orcall authentication has received an increasing amount ofattention in IVR industry. However due to the complexity ofspeaker information embedded in the speech signals thecurrent technology still can not produce the verificationaccuracy to meet the requirement for some applications. In thispaper we introduce a new pattern classification approach,support vector machines (SVM) for the text-independentspeaker verification. The SVM is a new way of statisticallearning based on a principle of structural risk minimisation.In the paper various evaluation results for the SVMverification system are presented and a comparison with abaseline GMM approach is also given. The results demonstratethat the SVM approach perform much better than the GMMapproach. On the same training and testing data set the SVMapproach gives an EER 1.2% versus 3.9% EER from theGMM approach. 1. Introduction In the recent years the technology for speaker verification(SV) or call authentication has received an increasing amountof attention in IVR industry. However due to the complexityof speaker information embedded in the speech signals thecurrent technology such as HMM, GMM, ANN etc. still cannot produce the verification accuracy to meet the requirementfor some applications. In this paper we introduce a newapproach support vector machines (SVM) for this problem.The SVM is a learning technique introduced by V. Vapnik [1].It can be seen as a new way to statistical learning based on aprinciple of structural risk minimisation. An explicit noisedescription in the approach and the possibility of using non-linear kernel in the dual representation makes this method veryattractive in many pattern recognition areas. The technique hasbeen applied in the area of computer vision and others.Recently some works have shown that the algorithm canachieve better phoneme classification accuracy than someconventional methods for speech processing [2][3]. This paperpresents a text-independent SV system using the SVMapproach. In the paper some alternatives in the kernelfunctions and decision functions are discussed and evaluationresults are presented. The Gaussian mixture model (GMM)technique, one of most popular approach for the text-independent SV, is used as a baseline in our evaluations. Acomparison between the SVM and the GMM approach isgiven in the paper. Results demonstrate that the SVMalgorithm perform much better than the baseline GMM. Onthe same training and testing data set the SVM approach givesan equal error rate (EER) 1.2% versus 3.9% from the GMM.
Query-driven context aware recommendation (2013)

Context aware recommender systems go beyond the traditional personalized recommendation models by incorporating a form of situational awareness. They provide recommendations that not only correspond to a user's preference profile, but that are also tailored to a given situation or context. We consider the setting in which contextual information is represented as a subset of an item feature space describing short-term interests or needs of a user in a given situation. This contextual information can be provided by the user in the form of an explicit query, or derived implicitly.
The Role of Pitx2 in Maintaining the Phenotype of Myogenic Precursor Cells in the Extraocular Muscles (2013)

Many differences exist between extraocular muscles (EOM) and non-cranial skeletal muscles. One striking difference is the sparing of EOM in various muscular dystrophies compared to non-cranial skeletal muscles. EOM undergo continuous myonuclear remodeling in normal, uninjured adults, and distinct transcription factors are required for the early determination, development, and maintenance of EOM compared to limb skeletal muscle. Pitx2, a bicoid-like homeobox transcription factor, is required for the development of EOM and the maintenance of characteristic properties of the adult EOM phenotype, but is not required for the development of limb muscle. We hypothesize that these unique properties of EOM contribute to the constitutive differences between EOM and non-craniofacial skeletal muscles. Using flow cytometry, CD34(+)/Sca1(-/)CD45(-/)CD31(-) cells (EECD34 cells) were isolated from extraocular and limb skeletal muscle and in vitro, EOM EECD34 cells proliferated faster than limb muscle EECD34 cells. To further define these myogenic precursor cells from EOM and limb skeletal muscle, they were analyzed for their expression of Pitx2. Western blotting and immunohistochemical data demonstrated that EOM express higher levels of Pitx2 than limb muscle, and 80% of the EECD34 cells expressed Pitx2. siRNA knockdown of Pitx2 expression in EECD34 cells in vitro decreased proliferation rates and impaired the ability of EECD34 cells to fuse into multinucleated myotubes. High levels of Pitx2 were retained in dystrophic and aging mouse EOM and the EOM EECD34 cells compared to limb muscle. The differential expression of Pitx2 between EOM and limb skeletal muscle along with the functional changes in response to lower levels of Pitx2 expression in the myogenic precursor cells suggest a role for Pitx2 in the maintenance of constitutive differences between EOM and limb skeletal muscle that may contribute to the sparing of EOM in muscular dystrophies.
[In vitro antibacterial activities of cefteram and other beta-lactam agents against recent clinical isolates]. (1998)

In vitro antibacterial activity of the third-generation oral cephem cefteram (CFTM)--ten years after its first use in the clinical setting--against recent clinical isolates was evaluated and compared with those of other oral cephems. A total of 851 clinical isolates belonging to 13 species used in this study were collected from five medical institutions across Japan during 1996. CFTM showed excellent antibacterial activity against methicillin-susceptible S. aureus and S. pyogenes, equivalent to those of other third-generation oral cephems, except cefixime. Of the S. pneumoniae strains, a high proportion, 34.1%, were penicillin-resistant strains (PRSP), with MIC values of 2.0 micrograms/ml or above, but the MIC50 of CFTM against PRSP was 1.0 microgram/ml. CFTM and the other third-generation oral cephems showed potent antibacterial activity against E. coli, K. pneumoniae, and P. mirabilis. A few strains of E. coli, however, were highly resistant to third-generation oral cephems; that might include extended-spectrum beta-lactamase producing strains. MIC values against P. vulgaris varied significantly, depending on whether they were determined by the broth micro-dilution method or the agar dilution method; growth was observed at high concentrations in the broth micro-dilution method, in which the skip phenomenon was demonstrated, but not in the agar dilution method. The reason for this discrepancy is unknown. Most strains of S. marcescens, C. freundii, and E. cloacae demonstrated resistance to CFTM and the other third-generation oral cephems. CFTM and the other third-generation oral cephems showed excellent antibacterial activities against M. (B.) catarrhalis, N. gonorrhoeae, and H. influenzae, including ampicillin-resistant strains.
Two’s company, three (or more) is a simplex (2016)

The language of graph theory, or network science, has proven to be an exceptional tool for addressing myriad problems in neuroscience. Yet, the use of networks is predicated on a critical simplifying assumption: that the quintessential unit of interest in a brain is a dyad – two nodes (neurons or brain regions) connected by an edge. While rarely mentioned, this fundamental assumption inherently limits the types of neural structure and function that graphs can be used to model. Here, we describe a generalization of graphs that overcomes these limitations, thereby offering a broad range of new possibilities in terms of modeling and measuring neural phenomena. Specifically, we explore the use of simplicial complexes: a structure developed in the field of mathematics known as algebraic topology, of increasing applicability to real data due to a rapidly growing computational toolset. We review the underlying mathematical formalism as well as the budding literature applying simplicial complexes to neural data, from electrophysiological recordings in animal models to hemodynamic fluctuations in humans. Based on the exceptional flexibility of the tools and recent ground-breaking insights into neural function, we posit that this framework has the potential to eclipse graph theory in unraveling the fundamental mysteries of cognition.
Attempted synthesis of 2-methylalanyl-L-prolyl-L-tryptophan. An unexpected result (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAttempted synthesis of 2-methylalanyl-L-prolyl-L-tryptophan. An unexpected resultJ. T. Gerig and R. S. McLeodCite this: J. Org. Chem. 1976, 41, 9, 1653–1655Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://doi.org/10.1021/jo00871a042Request reuse permissionsArticle Views78Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (483 KB) Get e-Alertsclose Get e-Alerts
Short Notices (1984)

Short Notices GEOFFREY HAND GEOFFREY HAND University of Birmingham Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume XCIX, Issue CCCXC, January 1984, Pages 152–153, https://doi.org/10.1093/ehr/XCIX.CCCXC.152 Published: 01 January 1984
GaAs1−<i>x</i>P<i>x</i> DIODE PUMPED YAG: Nd LASERS (1971)

Experiments using GaAs1−xPx diodes emitting at 8100 Å to cw pump YAG: Nd laser rods are described. At an electrical input power of 7.6 W to an array of 4% efficient diodes operating at room-temperature threshold was attained for a laser rod, with high-reflectivity mirrors, cooled to 3.5°C. For a laser rod with a 0.4% transmission output mirror threshold was reached at −2.5°C. From threshold-temperature-dependence data for the latter rod, an extrapolation has been made showing that a straightforward increase in the number of diodes by a factor of 3 to 4 will result in threshold being exceeded by 2 to 3 times at a rod temperature of 20°C.
Rhodium–Phosphite SILP Catalysis for the Highly Selective Hydroformylation of Mixed C<sub>4</sub> Feedstocks (2011)

The cat. that got the butene: Highly active and selective diphosphite ligands are applied for rhodium-catalyzed supported ionic liquid phase (SILP) hydroformylation and make it possible to form linear n-pentanal with exceptional selectivity from a mixed butene feedstock by combined isomerization and hydroformylation (see picture, vials 1–4 show typical SILP catalysts employed in this study.). The SILP catalyst is stable for more than 800 h on stream. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31) (1997)

Aggregation of many cell-surface receptors results in tyrosine phosphorylation of numerous proteins. We previously observed the tyrosine phosphorylation of the platelet/endothelial cell adhesion molecule, PECAM-1 (CD31), after FcepsilonRI stimulation in rat basophilic leukemia RBL-2H3 cells. Here we found that PECAM-1 was also transiently tyrosine-phosphoryated after adherence of these cells to fibronectin. Similarly aggregation of the T cell receptor on Jurkat cells also induced this tyrosine phosphorylation. The protein-tyrosine phosphatase SHP-2 is a widely expressed cytosolic enzyme with two Src homology 2 (SH2) domains. SHP-2, but not the related protein-tyrosine phosphatase SHP-1, associated with PECAM-1. This association of the two proteins correlated with the extent of the tyrosine phosphorylation of PECAM-1. A fusion protein containing the two SH2 domains of SHP-2 precipitated PECAM-1 from cell lysates and also directly bound to phosphorylated PECAM-1. In immune precipitate phosphatase assays, there was tyrosine dephosphorylation of PECAM-1. Therefore, integrin and immune receptor activation results in tyrosine phosphorylation of PECAM-1 and the binding of the protein-tyrosine phosphatase SHP-2, which could regulate receptor-mediated signaling in cells.
Engagement and the spread of fake news: Personality Trait as moderator (2018)

The speed of news is no longer limited.Distance and time limits do not become an obstacle in the rate of news spread.Even though the access to the information, nowadays is more accessible and fast, but there are also many another adverse offer, such as spreading rumors and fake news.Individual engagement with high intensity and have personal meaning with their social media platform could meet their need to contribute, retrieve and explore the news content and also have tendencies to spread the fake news.Previous studies have shown that personality traits play a significant role in human behavior.This study aims to investigate the roles of personality in engagement and spreading fake news behavior.Furthermore, The purpose of this study is to offer a theoretical and empirical background to explain the psychological aspects of the issue of spreading the fake news.This study conceptualizes false news as a distorted signal inconsistent with the truth.Result of this study show that personality traits with extraversion characteristic moderate personal engagement to intention for spread fake news exposures.