gebhart/patrepeval huggingface dataset:
Diallylpolysulfides induce growth arrest and apoptosis (2010)

Garlic-derived organo sulphur compounds such as diallylsulfides provide a significant protection against carcinogenesis. Chemically synthesized, and highly pure diallylsulfides with a chain of 1-4 sulphur atoms, as well as a range of control compounds, were employed to investigate the influence of these agents on cell viability, cell cycle arrest and induction of apoptosis in HCT116 human colon cancer cells. Diallyltrisulfide, and even more efficiently diallyltetrasulfide treatment of HCT116 cells led to a reduced cell viability, cell cycle arrest and apoptosis. A similar activity was found for the propyl-analogues, while mono- and disulfides were considerably less active. Initial calculations point toward the ability of tri- and tetrasulfides to form reactive oxygen species (ROS). Here, we found that the induction of apoptosis was indeed dependent on the redox-state of the cell, with anti-oxidants being able to prevent sulfide-induced apoptosis. Furthermore, using HCT116 cells which were either positive or negative for p53 revealed that p53 is clearly dispensable for induction of apoptosis. Growth arrest and induction of apoptosis is associated with a considerable reduction of the level of cdc25C. These results support the therapeutic potential of polysulfides and allow insight into the mechanisms based on the polysulfide biochemistry.
Weighted Least Squares Techniques for Improved Received Signal Strength Based Localization (2011)

The practical deployment of wireless positioning systems requires minimizing the calibration procedures while improving the location estimation accuracy. Received Signal Strength localization techniques using propagation channel models are the simplest alternative, but they are usually designed under the assumption that the radio propagation model is to be perfectly characterized a priori. In practice, this assumption does not hold and the localization results are affected by the inaccuracies of the theoretical, roughly calibrated or just imperfect channel models used to compute location. In this paper, we propose the use of weighted multilateration techniques to gain robustness with respect to these inaccuracies, reducing the dependency of having an optimal channel model. In particular, we propose two weighted least squares techniques based on the standard hyperbolic and circular positioning algorithms that specifically consider the accuracies of the different measurements to obtain a better estimation of the position. These techniques are compared to the standard hyperbolic and circular positioning techniques through both numerical simulations and an exhaustive set of real experiments on different types of wireless networks (a wireless sensor network, a WiFi network and a Bluetooth network). The algorithms not only produce better localization results with a very limited overhead in terms of computational cost but also achieve a greater robustness to inaccuracies in channel modeling.
Automatic coarse-grain partitioning and automatic code generation for heterogeneous architectures (2004)

Real time signal, image, and control applications have very important time constraints, involving the use of several powerful numerical calculation units. The aim of our project is to develop a fast and automatic prototyping process dedicated to parallel architectures made of both PC and several last generation Texas Instruments digital signal processors: TMS320C6X DSP. The process is based on SynDEx, a CAD software improving algorithm implementation onto multiprocessor architectures by finding the best matching between an algorithm and an architecture. SynDEx kernels for automatic PC and DSP dedicated code generation have been developed with the new SynDEx functionalities. A full coding application illustrates the results. The application is an image compression algorithm called LAR (locally adaptive resolution).
What Kind of Optical Fiber for Long-Distance Transmission? (1970)

A comparison is made between clad fibers and lens-like guides with parabolic index profiles, from several points of view: delay distortion, beam capacity per unit cross section, ability to negotiate bends, and deterioration of transmission due to imperfections. Theoretical and experimental quantitative comparisons are also presented.
2‐D. charge‐transfer molecules for second order nlo: off‐diagonal orientation (1995)

Second order nonlinear optical materials based on two‐dimensional charge‐transfer molecules rather than one‐dimensional molecules offer a number of advantages. For example, the 2‐D CT molecules retain their second order nonlinearity even if they are inclined away from normal to the substrate. This interesting class of new materials is presented and the factors influencing the performances of the materials, such as the incorporation of long π‐conjugated segments into the molecules, are discussed.
Fast semi-local alignment for DNA sequence database search (2003)

Given a query DNA sequence, our goal is to find in the DNA sequence database all the sequence segments that are similar to the query. We present a string-to-signal transform technique that can transform a DNA sequence into a four-channel signal. Without considering gaps, the edit distance between two DNA sequences can be calculated as the sum of absolute difference (SAD) between their corresponding four-channel signals. The algorithm proposed can then be applied to speed up the process of searching for the desired sequence segments that yield small SADs. In addition to efficiency, this algorithm guarantees the optimal search. That is, all the sequence segments that are similar enough to the query can be found without any miss.
Rolling Resistance and Fatigue Life of Tires (1988)

Abstract The elastic energy amplitude to which every point of a rotating tire is subjected to, leads to an increase of temperature in the tire as some of this energy is converted into heat because of the viscoelastic nature of rubber. It also influences the fatigue life of a tire, since the rate of crack growth depends both on the energy input and the temperature which results from the energy loss.
<scp>PIPITS</scp>: an automated pipeline for analyses of fungal internal transcribed spacer sequences from the <scp>I</scp>llumina sequencing platform (2015)

Studying fungal biodiversity using data generated from Illumina MiSeq sequencing platforms poses a number of bioinformatic challenges with the analysis typically involving a large number of tools for each analytical step from quality filtering to generating identified operational taxonomic unit (OTU) abundance tables.Here, we introduce PIPITS, an open-source stand-alone suite of software for automated processing of Illumina MiSeq sequences for fungal community analysis. PIPITS exploits a number of state of the art applications to process paired-end reads from quality filtering to producing OTU abundance tables.We provide detailed descriptions of the pipeline and show its utility in the analysis of 9 396 092 sequences generated on the MiSeq platform from Illumina MiSeq. PIPITS is the first automated bioinformatics pipeline dedicated for fungal ITS sequences which incorporates ITSx to extract subregions of ITS and exploits the latest RDP Classifier to classify sequences against the curated UNITE fungal data set.
The Origins of American Intervention in North Russia (1918) (1938)

Journal Article The Origins of American Intervention in North Russia (1918). By Leonid I. Strakhovsky. (Princeton: Princeton University Press, 1937. xii + 140 pp. Bibliography and appendix. $2.00.) Get access Meribeth E. Cameron Meribeth E. Cameron Western Reserve University Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 25, Issue 2, September 1938, Page 286, https://doi.org/10.2307/1896522 Published: 01 September 1938
Temporomandibular Disorders (2008)

This review discusses the most common forms of temporomandibular disorders: myofascial pain disorder, intra-articular disk derangement disorders, osteoarthritis, and rheumatoid arthritis. Current views on its pathogenesis and presentation and recommended diagnostic studies and treatment approaches are discussed.
Cytotoxicity and Cell Interaction Studies of Bioadhesive Poly(anhydride) Nanoparticles for Oral Antigen/Drug Delivery (2013)

The use of bioadhesive polymers as nanodevices has emerged as a promising strategy for oral delivery of therapeutics. In this regard, poly(anhydride) nanoparticles have shown great potential for oral drug delivery and vaccine purposes. However, despite extensive research into the biomedical and pharmaceutical applications of poly(anhydride) nanoparticles, there are no studies to evaluate the interaction of these nanoparticles at a cellular level. Therefore, the main objectives of this study were to evaluate the cytotoxicity as well as the cell interaction of different poly(anhydride) nanoparticles: conventional (NP), nanoparticles containing 2-hydroxypropyl-beta-cyclodextrin (NP-HPCD) and nanoparticles coated with poly(ethylene glycol) 6000 (PEG-NP). For this purpose, nanoparticles were prepared by solvent displacement method and labelled with BSA-FITC. Nanoparticles displayed a size about 175 nm with negative surface charge. Cytotoxicity studies were developed by MTS and LDH assays in HepG2 and Caco-2 cells. Results showed that only in HepG2 cells, NP and NP-HPCD induced significant cytotoxicity at the highest concentrations (1 and 2 mg/mL) and incubation times (48 and 72 h) tested. Studies to discriminate between cytoadhesion and cytoinvasion were performed at 4 degrees C and 37 degrees C in Caco-2 cell line as intestinal cell model. Nanoparticles showed cytoadhesion to the cell surface but not internalization; PEG-NP was the most bioadhesive followed by NP-HPCD and NP as demonstrated by flow cytometry. Finally, cellular localization of particles by fluorescence confocal microscopy confirmed the association of these nanoparticles with cells. Thus, this study demonstrated the safety of NP, NP-HPCD and PEG-NP at cellular level and its bioadhesive properties within cells.
Widely Linear Blind Adaptive Equalization for Transmitter IQ-Imbalance/Skew Compensation in Multicarrier Systems (2016)

Simple analytical widely linear complex-valued models for IQ-imbalance and IQ-skew effects in multicarrier transmitters are presented. To compensate for such effects, a 4×4 MIMO widely linear adaptive equalizer is proposed and experimentally validated.
Insulin and growth factors stimulate the phosphorylation of a <i>M</i>r-22000 protein in 3T3-L1 adipocytes (1983)

Insulin, epidermal growth factor (EGF), platelet-derived growth factor, multiplication-stimulating activity and 10% foetal-calf serum each stimulated the phosphorylation of a cytosolic Mr-22000 acidic heat-stable protein in Swiss mouse 3T3-L1 adipocytes. Phosphorylation of this protein was not stimulated by isoprenaline or dibutyryl cyclic AMP. The effect of insulin was maximal (3-fold increase) by 10 min; half-maximal stimulation was observed at 70 pM-insulin. Both [32P]phosphoserine and [32P]phosphothreonine residues were present in the Mr-22000 protein after insulin- and growth-factor-stimulated phosphorylation, but no [32P]phosphotyrosine. The major site of insulin- and EGF-stimulated phosphorylation appeared to be a threonine residue, in contrast with previously studied insulin-stimulated phosphorylation of serine residues. Insulin treatment appeared to result in a shift of the protein toward the anode on isoelectric focusing. Insulin and EGF present simultaneously did not lead to phosphorylation beyond that seen with each hormone singly. We surmise that insulin, EGF and perhaps other growth factors may activate a common protein kinase or inhibit a common protein phosphatase in 3T3-L1 adipocytes which acts on the Mr-22000 protein.
Increased neutrophil apoptosis in chronic fatigue syndrome: Table 1 (2004)

These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.
Evidence for Initial Involvement of Macrophage in Development of Insulitis in NOD Mice (1988)

Macrophages have been shown to be the major population of infiltrated immunocytes at the early stage of insulitis in diabetes-prone BB rats. This study was undertaken to investigate the role of macrophages in the development of insulitis in nonobese diabetic (NOD) mice. Administration of cyclophosphamide to NOD mice resulted in a significant increase in the incidence of overt diabetes and severity of insulitis compared with that in untreated NOD mice. Intraperitoneal injections of silica completely prevented the development of diabetes and insulitis in both cyclophosphamide-treated and untreated animals. Because silica is selectively toxic to macrophages, the results suggest that macrophages play an important role in the initiation of insulitis in NOD mice.
Asymmetric clustering using a register cache (2006)

Conventional register files spread porting resources uniformly across all registers. This paper proposes a method called Asymmetric Clustering using a Register Cache (ACRC). ACRC utilizes a fast register cache that concentrates valuable register file ports to the most active registers thereby reducing the total register file area and power consumption. A cluster of functional units and a highly ported register cache execute the majority of instructions, while a second cluster with a full register file having fewer read ports processes instructions with source registers not found in the register cache. An ‘in-cache ’ marking system tracks the contents of the register cache and routes instructions to the correct cluster. This system utilizes logic similar to the ‘ready ’ bit system found in wake-up and select logic keeping the additional logic required to a minimum. When using a 256-entry register file, this design reduces the total register file area by an estimated 65 % while exhibiting similar IPC performance compared to a non-clustered 8-way processor. As the feature size becomes smaller and processor clocks become faster, the number of clock cycles needed to access the register file will increase. Therefore, the smaller register file area requirement and subsequent smaller register file delay of ACRC will lead to better IPC performance than conventional processors. 1.
Technetium-99m-kethoxal-bis(thiosemicarbazone), an uncharged complex with a tetravalent 99mTc state, and its excretion into the bile. (1976)

Technetium-99m-kethoxal-bis (thiosemicarbazone) complex (99mTc-KTS), a potentially useful radiopharmaceutical for cholescintigraphy, is prepared by the reaction of KTS with 99mTcO4- in the presence of stannous chloride. Under the described conditions, a complex extractable with organic solvent was detected. Thin-layer chromatography, electrophoresis, and spectrometric analysis indicate the formation of an uncharged 99mTc(IV) complex. Organ distribution and biliary excretion studies are described. The complex showed a marked highly reproducible accumulation in the gallbladder.
HARPSS-fabricated nano-gap comb-drive for efficient linear actuation of high frequency BAW resonators (2016)

This paper presents the design, fabrication and characterization of self-aligned nano-gap comb-drive actuators for high frequency bulk acoustic wave (BAW) resonators. The comb-drive is implemented to actuate a high-Q 1 MHz annulus BAW resonator with gyroscopic modes. Measurements show a linear force density of 261.5 pN/V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> μm, which is to the authors' knowledge the largest force density reported to date for silicon comb-drives. As a result, vibration amplitudes as large as 350 nm are measured using relatively small voltages. An equivalent model estimation of the mechanical nonlinearity of the resonator indicates a spring hardening effect at large displacements, which is confirmed by experimental results.
Inflammation and matrix remodeling during repair of ventilator-induced lung injury (2011)

High-pressure ventilation triggers different inflammatory and matrix remodeling responses within the lung. Although some of them may cause injury, the involvement of these mediators in repair is largely unknown. To identify mechanisms of repair after ventilator-induced lung injury (VILI), mice were randomly assigned to baseline conditions (no ventilation), injury [90 min of high-pressure ventilation without positive end-expiratory pressure (PEEP)], repair (injury followed by 4 h of low-pressure ventilation with PEEP), and ventilated controls (low-pressure ventilation with PEEP for 90 and 330 min). Histological injury and lung permeability increased during injury, but were partially reverted in the repair group. This was accompanied by a proinflammatory response, together with increases in TNF-α and IFN-γ, which returned to baseline during repair, and a decrease in IL-10. However, macrophage inflammatory protein-2 (MIP-2) and matrix metalloproteinases (MMP)-2 and -9 increased after injury and persisted in being elevated during repair. Mortality in the repair phase was 50%. Survivors showed increased cell proliferation, lower levels of collagen, and higher levels of MIP-2 and MMP-2. Pan-MMP or specific MMP-2 inhibition (but not MIP-2, TNF-α, or IL-4 inhibition) delayed epithelial repair in an in vitro wound model using murine or human alveolar cells cultured in the presence of bronchoalveolar lavage fluid from mice during the repair phase or from patients with acute respiratory distress syndrome, respectively. Similarly, MMP inhibition with doxycycline impaired lung repair after VILI in vivo. In conclusion, VILI can be reverted by normalizing ventilation pressures. An adequate inflammatory response and extracellular matrix remodeling are essential for recovery. MMP-2 could play a key role in epithelial repair after VILI and acute respiratory distress syndrome.
Chromatin domain surrounding the human interferon-.beta. gene as defined by scaffold-attached regions (1988)

Regions attached to the nuclear scaffold have been traced after transfecting a 36-kilobase (kb) piece of DNA, surrounding the human interferon-beta gene, into mouse L-cells. An extended attached region starts 1.7 kb upstream from the gene and a moderate binding site immediately downstream. These findings could be confirmed by reconstitution experiments in vitro which predict another scaffold-attached region (SAR) starting 12 kb downstream from the gene. Since no other transcripts originate from DNA between the major SARs, these elements could be involved in interferon gene regulation.
Escape analysis on lists (1992)

Higher order functional programs constantly allocate objects dynamically. These objects are typically cons cells, closures, and records and are generally allocated in the heap and reclaimed later by some garbage collection process. This paper describes a compile time analysis, called escape analysis, for determining the lifetime of dynamically created objects in higher order functional programs, and describes optimizations that can be performed, based on the analysis, to improve storage allocation and reclamation of such objects. In particular, our analysis can be applied to programs manipulating lists, in which case optimizations can be performed to allow cons cells in spines of lists to be either reclaimed immediately or reused without incurring any garbage collection overhead. In a previous paper on escape analysis [10], we had left open the problem of performing escape analysis on lists.
VM-centric snapshot deduplication for cloud data backup (2015)

Data deduplication is important for snapshot backup of virtual machines (VMs) because of excessive redundant content. Fingerprint search for source-side duplicate detection is resource intensive when the backup service for VMs is co-located with other cloud services. This paper presents the design and analysis of a fast VM-centric backup service with a tradeoff for a competitive deduplication efficiency while using small computing resources, suitable for running on a converged cloud architecture that cohosts many other services. The design consideration includes VM-centric file system block management for the increased VM snapshot availability. This paper describes an evaluation of this VM-centric scheme to assess its deduplication efficiency, resource usage, and fault tolerance.
Repeaterless optical transmission at 10 Gbit/s via 182 km of standard singlemode fibre using a high power booster amplifier (1993)

Using the new method of dispersion supported transmission, high power signals of + 19 dBm at 10 Gbit/s are transmitted on standard singlemode fibre via the record length of 182 km without inline amplification. The robustness of the transmission scheme against nonlinear effects is verified.
Paleogene evolution of the Kodiak Islands, Alaska: Consequences of ridge‐trench interaction in a more southerly latitude (1983)

The Kodiak Islands of Alaska are principally composed of a Late Cretaceous and Paleogene complex of accreted deep‐sea rocks. An early Paleocene magmatic event invaded the accretionary complex with mid‐ocean ridge basalt (MORB), andesite, and granodiorite. Geochemical evidence suggests both the andesite and granodiorite are mixtures of MORB and sediment. The volcanic rocks are interlayered with coarse clastic sediments and deformed with the latter; the granodioritic intrusions, with K‐Ar ages as old as 62 Ma postdate emplacement of the early Paleocene sedimentary and volcanic rocks. Interaction of the subduction complex with the Kula‐Farallon ridge most simply explains this early Paleocene magmatic episode. Paleomagnetic studies of the volcanic rocks indicate this interaction occurred at 40.3±6° north latitude, which is 25.3±9° south of the expected position of the Kodiak Islands relative to North America. The magmatic arc presently northwest of the Kodiak accretionary complex was active during the Late Cretaceous and early Paleocene, diminished after the ridge‐trench interaction, and resurged from late Eocene into Miocene time. The magmatic resurgence is coeval with the obductive offscraping of Eocene to Oligocene(?) submarine fan deposits in the Kodiak Islands. The petrology of these fan deposits indicates they are the most likely proximal equivalent for the Zodiac fan, thereby limiting its relative motion with respect to the Kodiak Islands. Possible models accounting for the northward motion of the Kodiak accretionary complex include (1) coupling the accretionary complex and possibly related arc to the northward‐moving Kula Plate and closing an ocean basin north of the arc in Paleogene time, (2) emplacing the Kodiak accretionary complex at the northward limit of the paleomagnetic data, with subsequent northward motion accomplished by closure of a small back arc basin and/or intracontinental shortening, and (3) transcurrent faulting and northward motion of the Kodiak accretionary complex without the presently adjacent arc.