gebhart/patrepeval huggingface dataset:
α-(N-Alkylamino)-nitriles (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTα-(N-Alkylamino)-nitrilesLawrence J. Exner, Leo S. Luskin, and Peter L. deBennevilleCite this: J. Am. Chem. Soc. 1953, 75, 19, 4841–4842Publication Date (Print):October 1, 1953Publication History Published online1 May 2002Published inissue 1 October 1953https://pubs.acs.org/doi/10.1021/ja01115a513https://doi.org/10.1021/ja01115a513research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Occupational exposure to metalworking fluids and risk of breast cancer among female autoworkers (2005)

This hypothesis-generating study provides some preliminary evidence for an association between exposure to soluble MWF and increased risk of breast cancer. Additional studies of MWF and breast cancer, with data on known breast cancer risk factors, are warranted.
The association of endogenous Go alpha with the purified omega-conotoxin GVIA receptor. (1994)

Modulation of the neuronal omega-conotoxin GVIA-sensitive N-type voltage-dependent calcium channel (VDCC) by neurotransmitters and guanine nucleotides suggests a dynamic interaction between activated G-protein alpha subunits and the N-type VDCC. Our previous report on the purification of the N-type VDCC (McEnery, M. W., Snowman, A. M., Sharp, A. H., Adams, M. E., and Snyder, S. H. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 11095-11099), has led us to investigate a possible association of CTXR with an endogenous G alpha subunit. The addition of the G-protein activator AIF4- modulated the 125I-CTX binding characteristics of the solubilized CTXR. Further immunological analyses employing G alpha subunit-specific antibodies to monitor the cofractionation of G alpha with 125I-CTX binding activity throughout the purification procedure indicate the selective recovery of Go alpha in the purified CTXR preparation, as neither Gs alpha, Gi alpha, nor G beta gamma could be detected. Furthermore, Go alpha associated with CTXR acted as a substrate for pertussis toxin-dependent ADP-ribosylation only upon the addition of exogenous G beta gamma subunits. These results strongly indicate a high affinity complex between an activated Go alpha and CTXR maintained throughout biochemical purification of the 125I-CTX receptor.
Efficient non-resonant energy transfer in Nd^3+-Yb^3+ codoped Ba-Al-metaphosphate glasses (2010)

An efficient Nd3+→Yb3+ energy transfer in a new series of alkali-free barium-alumino-metaphosphate glasses with a transfer efficiency reaching up to 95% has been reported here. It is due to the effective phonon assistance arising with the excellent matching of the present host phonon energy with the energy mismatch between Nd3+(4F3/2) and Yb3+(2F5/2) excited levels. The energy transfer microparameters for Nd3+→Yb3+ forward and back energy transfers are estimated from the spectral data analysis. A parameter, ΦET(=CDANd-Yb/CDANd-Nd), is proposed as a quantitative measure of sensitization ability per unit loss of the donor. The parameter is found to be highest for the presently reported barium-alumino-metaphosphate glasses.
<title>Programmable Image Processing Element</title> (1982)

The algorithmic solution to many image-processing problems frequently uses sums of products where each multiplicand is an input sample (pixel) and each multiplier is a stored coefficient. This paper presents a large-scale integrated circuit (LSIC) implementation that provides accumulation of nine products and discusses its evolution from design through application 'A read-only memory (ROM) accumulate algorithm is used to perform the multiplications and is the key to one-chip implementation. The ROM function is actually implemented with erasable programmable ROM (EPROM) to allow reprogramming of the circuit to a variety of different functions. A real-time brassboard is being constructed to demonstrate four different image-processing operations on TV images.
Experimental and numerical analyses of the shimming effect on bolted joints with nonuniform gaps (2018)

In order to investigate the effect of shim compensation for nonuniform gaps in aircraft assembly, the influence of the shims with different material and parameters on bolted joints is studied in this paper. According to the real material and assembly conditions of the aircraft joint structures, the specimen and experiment are designed to obtain the tensile performance of the joint structures with different shims. A three-dimensional finite element model, which incorporates the Johnson–Cook material property of the alloys, traction-separation law of liquid shims, contact relationships between the joint elements, and boundary conditions of the tensile process, is established with the specimen configurations. After validating through comparing with the experimental results, the modeling method is adopted to simulate the tensile response of the bolted joints with shims. Furthermore, both the influence of the shim material and thickness on the mechanical behaviors of bolted joints is investigated in detail. Shims can considerably reduce the assembly stress of joint structures and improve the joint stiffness and load capacity, and this effect is more remarkable with the increase of gap values. Liquid shims improve the joint stiffness due to its cohesive ability, while solid shims improve the joint load capacity. Hybrid shims possess a composite shimming effect of liquid and solid shims. Whatever the shim material is applied, the joint stiffness and strength drop with the growth of shim thickness, so strict deviation control method should be taken to ensure the assembly gaps as small as possible. The research results enhance the knowledge of shimming effect on joint structures, and thus offer positive guidance for practical application in aircraft assembly.
A Novel Culture Method for High Level Production of Heterologous Protein in<i>Saccharomyces cerevisiae</i> (1994)

A high level production system for heterologous protein by cold culture of yeast transformants at 15 degrees C was developed. The yeast transformants, carrying a plasmid containing cDNA for Aspergillus oryzae alpha-amylase (Taka-amylase A) or human lysozyme synthetic DNA, were cultivated in a selective medium for 1 or 2 days until full growth at 30 degrees C. The yeast cells were harvested by centrifugation from the culture fluid and then were transferred to YPD medium. These inoculated broths were incubated for 2 days at 15 degrees C and then for another 2 days at 30 degrees C. By the cold culture method described above, higher amounts of Taka-amylase A (28.6 mg/liter) and human lysozyme (6.1 mg/liter) were produced by the yeast transformants compared to those by conventional methods. Heterologous protein productions using YEp, YCp, and YIp types of yeast expression vectors with ADH1 or GAPDH promoter by the cold culture method showed effective productivity of about 2-fold compared to those by the conventional method of culture at 30 degrees C. The high level production of heterologous protein by this method was not specific to the S. cerevisiae strains examined.
Enhance of Oil Production from an Old Well in Thin Carbonate Reservoir through Acid Tunneling - A Case Study (2013)

Abstract The effectiveness of stimulation using hydrochloric acid in high permeability, fractured carbonate reservoir is a challenge due to several reasons like fast acid spending rates, high leak off and non-effective diversion. All these limit the success rate of matrix stimulation using hydrochloric acid. Ultimately the communication between reservoir and wellbore will be less optimum leading to less than expected well performance. The industry is in continuous search of an effective stimulation technique through which good communication between reservoir and wellbore can be established. In the pursuit of maximizing oil production, Kuwait Oil Company is implementing various new technologies. Recently, acid tunneling technology was piloted in an old producer well in one of its prolific yet challenging Mauddud carbonate reservoir. Acid tunneling is a new approach of stimulation that supersedes normal matrix stimulation in carbonate reservoirs to enhance reservoir contact by creating tunnels through dissolution of rock in acid. Mauddud is a super-giant depletion-drive oil reservoir in NK field undergoing massive development efforts with enhancement in oil production through phased pattern-water flood. The reservoir has 10 layers and the average permeability of the reservoir ranges between 15 md to 1D predominantly due to fractures and vugs, which are distributed and extended variedly from layer to the other. The acid tunneling pilot was performed in an old well in Mauddud limestone located in south-eastern part of Raudhatain field where the rock quality is poor compared to the crestal area. The well was selected for pilot due to poor production. The well does not enjoy injection support due to a sealing fault between it and an injector, lying a kilometer away. The well penetrated three layers A, B and C in Mauddud. Two tunnels of 25 ft each were created using 15% HCl acid. The well showed good production after acid tunneling job and the productivity index of the well increased three times. The well is still showing good performance even after one year. These pilot results lead to full scale field implementation of this technology. The paper presents a case study describing advantages of acid tunneling, well selection criteria for this technology application, selection of effective acid concentration for the job and also limitations of the technology. All these informations work as a guideline to implement this technology in mass scale.
Copper Stress Affects Iron Homeostasis by Destabilizing Iron-Sulfur Cluster Formation in <i>Bacillus subtilis</i> (2010)

Copper and iron are essential elements for cellular growth. Although bacteria have to overcome limitations of these metals by affine and selective uptake, excessive amounts of both metals are toxic for the cells. Here we investigated the influences of copper stress on iron homeostasis in Bacillus subtilis, and we present evidence that copper excess leads to imbalances of intracellular iron metabolism by disturbing assembly of iron-sulfur cofactors. Connections between copper and iron homeostasis were initially observed in microarray studies showing upregulation of Fur-dependent genes under conditions of copper excess. This effect was found to be relieved in a csoR mutant showing constitutive copper efflux. In contrast, stronger Fur-dependent gene induction was found in a copper efflux-deficient copA mutant. A significant induction of the PerR regulon was not observed under copper stress, indicating that oxidative stress did not play a major role under these conditions. Intracellular iron and copper quantification revealed that the total iron content was stable during different states of copper excess or efflux and hence that global iron limitation did not account for copper-dependent Fur derepression. Strikingly, the microarray data for copper stress revealed a broad effect on the expression of genes coding for iron-sulfur cluster biogenesis (suf genes) and associated pathways such as cysteine biosynthesis and genes coding for iron-sulfur cluster proteins. Since these effects suggested an interaction of copper and iron-sulfur cluster maturation, a mutant with a conditional mutation of sufU, encoding the essential iron-sulfur scaffold protein in B. subtilis, was assayed for copper sensitivity, and its growth was found to be highly susceptible to copper stress. Further, different intracellular levels of SufU were found to influence the strength of Fur-dependent gene expression. By investigating the influence of copper on cluster-loaded SufU in vitro, Cu(I) was found to destabilize the scaffolded cluster at submicromolar concentrations. Thus, by interfering with iron-sulfur cluster formation, copper stress leads to enhanced expression of cluster scaffold and target proteins as well as iron and sulfur acquisition pathways, suggesting a possible feedback strategy to reestablish cluster biogenesis.
Diamagnetic Imaging Agents with a Modular Chemical Design for Quantitative Detection of β-Galactosidase and β-Glucuronidase Activities with CatalyCEST MRI (2016)

Imaging agents for the noninvasive in vivo detection of enzyme activity in preclinical and clinical settings could have fundamental implications in the field of drug discovery. Furthermore, a new class of targeted prodrug treatments takes advantage of high enzyme activity to tailor therapy and improve treatment outcomes. Herein, we report the design and synthesis of new magnetic resonance imaging (MRI) agents that quantitatively detect β-galactosidase and β-glucuronidase activities by measuring changes in chemical exchange saturation transfer (CEST). Based on a modular approach, we incorporated the enzymes' respective substrates to a salicylate moiety with a chromogenic spacer via a carbamate linkage. This furnished highly selective diamagnetic CEST agents that detected and quantified enzyme activities of glycoside hydrolase enzymes. Michaelis-Menten enzyme kinetics studies were performed by monitoring catalyCEST MRI signals, which were validated with UV-vis assays.
Performance optimization of the ThinPrep® processor: Effect of microscope slides (1998)

Our objective was to evaluate the cellular adherence property of various microscope slides. Slide preparations were made using the ThinPrep® 2000 System, in which cells are transferred from a filter to a slide. A total of eight slide types was selected for testing against the ThinPrep® microscope slide: S/P MicroSlide, S/P Pusher, S/P Colorfrost, Menzel Superfrost, Sayag, Sail Brand, Fisher Plus, and Newcomer Poly-L-Lysine. Gynecologic samples from 4 different patients were utilized on the ThinPrep® Processor. Multiple preparations were made from each sample using the different microscope slides. The slides were stained with a commercial Pap stain, and cellular material was quantified by scanning each preparation using a linear stage mounted on a Hitachi U-2000 spectrophotometer set at 580 nm. The data generated by this study show that ThinPrep microscope slides produce preparations with the highest level of cellular material. This study quantifies slide performance, examines a range of microscope slide types, and shows that ThinPrep microscope slides exhibit significantly increased cell adherence over the other slide types tested. Diagn. Cytopathol. 1998;19:388–391. © 1998 Wiley-Liss, Inc.
Fundamental studies of heterogeneous catalysis (1982)

This series of volumes is a unique summary of the present state of understanding of solid surfaces. The physical basis of chemisorption and heterogeneous catalysis is presented as a well-developed science with contributions from an international panel of chemists, physicists and metallurgists. The books are destined to become a fundamental and indispensable reference source for all those studying the nature of solid surfaces and catalysis.
Effect of Reconstruction Parameters on Tomographic Imaging of Rainfall Fields from Multi-Parameter Microwave Observables (2005)

.
Reviews (1974)

Journal Article Reviews Get access SAMUEL JOHNSON: A PERSONALITY IN CONFLICT , by George Irwin . Auckland University Press : Oxford University Press , 1971 ; pp. xiv, 168 ; £3.15. JAMES T. BOULTON JAMES T. BOULTON Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 21, Issue 2, February 1974, Pages 76–77, https://doi.org/10.1093/nq/21-2-76 Published: 01 February 1974
Potential Therapeutic Applications of Adenosine A<sub>2A</sub>Receptor Ligands and Opportunities for A<sub>2A</sub>Receptor Imaging (2017)

Adenosine A<sub>2A</sub> receptors (A<sub>2A</sub> Rs) are highly expressed in the human striatum, and at lower densities in the cerebral cortex, the hippocampus, and cells of the immune system. Antagonists of these receptors are potentially useful for the treatment of motor fluctuations, epilepsy, postischemic brain damage, or cognitive impairment, and for the control of an immune checkpoint during immunotherapy of cancer. A<sub>2A</sub> R agonists may suppress transplant rejection and graft-versus-host disease; be used to treat inflammatory disorders such as asthma, inflammatory bowel disease, and rheumatoid arthritis; be locally applied to promote wound healing and be employed in a strategy for transient opening of the blood-brain barrier (BBB) so that therapeutic drugs and monoclonal antibodies can enter the brain. Increasing A<sub>2A</sub> R signaling in adipose tissue is also a potential strategy to combat obesity. Several radioligands for positron emission tomography (PET) imaging of A<sub>2A</sub> Rs have been developed in recent years. This review article presents a critical overview of the potential therapeutic applications of A<sub>2A</sub> R ligands, the use of A<sub>2A</sub> R imaging in drug development, and opportunities and limitations of PET imaging in future research.
Trimodal Gadolinium-Gold Microcapsules Containing Pancreatic Islet Cells Restore Normoglycemia in Diabetic Mice and Can Be Tracked by Using US, CT, and Positive-Contrast MR Imaging (2011)

Cell encapsulation with GG provides a means of trimodal noninvasive tracking of engrafted cells.
Neonatal Cholestatic Conditions Requiring Surgical Reconstruction (1987)

Obstructive jaundice in infancy and childhood can arise from a variety of causes. Recognition of the importance of persistent jaundice beyond 2 weeks of age in the infant or elevation of the conjugated bilirubin more than 2 mg/dl will allow the timely evaluation of neonates with possible biliary atresia prior to the development of irreversible hepatic damage. Episodes of intermittent jaundice or persistent conjugated hyperbilirubinemia should be investigated at any age to exclude obstructive lesions of the extrahepatic biliary tract. In all cases, a rapid but carefully coordinated evaluation can be undertaken by a pediatric gastroenterology and surgical team, allowing optimum economy of effort and preservation of hepatic function. In nearly all cases with obstructive lesions of the extrahepatic biliary tree, satisfactory hepatic function can be preserved through appropriate surgical intervention. Results with biliary atresia continue to improve but are dependent on early diagnosis and treatment. In cases in which hepatic function deteriorates and hepatic failure becomes inevitable, orthotopic hepatic transplantation can be lifesaving and should be undertaken prior to the onset of irreversible hepatic decompensation. Although the terminology may be somewhat confusing and its etiology uncertain, the entity of choledochal cysts, taken within the context of its modern classification, accurately describes a group of cystic anomalies of the extrahepatic (and intrahepatic) biliary tree, which have many common features. The vast majority can be expeditiously dealt with by surgical excision and hepaticoenteral reconstruction. Two particular associations with choledochal cysts are important to note. When it occurs with infancy, choledochal cysts can be difficult to diagnose, but very important to define and treat expeditiously in order to prevent serious impairment of hepatic function. In all patients, but particularly in adults, the risk of associated carcinoma necessitates extremely careful definition of the biliary tree and urges one to advocate complete excision of the cyst at initial operation.
Averaged Differential Expression for the Discovery of Biomarkers in the Blood of Patients with Prostate Cancer (2012)

Averaged differential display offers a simplified approach for the comprehensive screening of body fluids, such as blood, to identify biomarkers in patients with prostate cancer. Furthermore, this proof-of-concept study warrants further analysis of RNF19A as a clinically relevant biomarker for prostate cancer detection.
Thalidomide in agnogenic and secondary myelofibrosis (2001)

Myelofibrosis with myeloid metaplasia (MMM) is a clonal disorder involving disregulation of angiogenesis and immunomodulatory mechanisms. Thalidomide (Thal) retains antiangiogenic, immunomodulatory and cytokine regulatory properties and recently it has been used successfully in multiple myeloma. Here, we report our experience in 10 MMM patients treated with Thal. Patients with agnogenic MMM treated in an early phase of the disease obtained significant benefits from the therapy and remain transfusion-free. In contrast, all secondary MMM failed to respond. These preliminary findings confirm that Thal plays a role in MMM therapy, although the efficacy in the different phases of the disease must be further evaluated.
[Effect of various solvents on the extraction of protein fractions of beans (Phaseolus vulgaris)]. (1983)

A study was carried out to determine the effect of different solvents on the extraction of protein fractions in beans. Black bean protein was extracted with the following solvents: distilled water, 0.01 M sodium hydroxide, 0.05 M sodium chloride, and 70% ethanol. By using each solvent under different conditions, it was possible to establish the optimum ones for the best extraction and fractionation of proteins from leguminous seeds. These conditions were the following: one hour agitation at room temperature, three successive extractions with the same solvent, and a ratio of solid to solvent of 1:20 W/V. The effect of 24 different sequences of solvents upon the extraction of protein was also investigated. From the extraction point of view, the best sequence of solvents for extracting the protein was that where NaOH constituted the first solvent used; this sequence, however, has the disadvantage of extracting all the protein from the seed, making it impossible to separate other protein fractions by another solvent. If the purpose of the extraction is to separate different protein fractions, the best sequence of solvents is distilled water or sodium chloride in the first place, followed by ethanol and sodium hydroxide. The need for using standardized methodology for the fractionation of protein from seeds in order to obtain comparable data between research laboratories is emphasized.