gebhart/patrepeval huggingface dataset:
Arachidonic acid production by the red alga <i>Porphyridium cruentum</i> (1983)

The single-celled alga, Porphyridium cruentum, was assessed by means of chromatographic separation and mass spectral analysis of its fatty acids to be a potentially competetive source of arachidonic (5,8,11,14-eicosatetraenoic) acid. Models for both cell growth and production of the prostaglandin precursor at various temperatures and light intensities are presented. Increasing the light intensity within the range 1700-8000 lux increases the cell growth rate without affecting the arachidonic acid yield per cell; increasing the cultivation temperature from 18 degrees C to ca. 32 degrees C lowers the yield of arachidonic acid per cell but increases the rate of its production per unit volume and time. The increase of the weight ratio of arachidonic:palmitic acids at low temperatures is interpreted as a means of controlling the microviscosities of cellular membranes. In addition, the arachidonic acid content of cells decreases with the culture's age, despite increases in unit cell dry weight. The maximum rate of 0.46 mg arachidonic acid L(-1) h(-1) was calculated by means of the model to occur at ca. 32 degrees C and 8000 lux in liquid cultures of 12 x 10(9) cells/L. Estimates of the cost of producing arachidonic acid by means of this alga range from $0.15/g to $1.00/g of arachidonic acid. Cells grown at 18 degrees C in the presence of 0.3% linoleic acid swelled and produced gorlic (13-cyclopent-2-enyltridec-6-enoic) acid and another compound not normally observed. An estimated threefold increase of arachidonic acid content also occurred, but no significant lipogenesis was induced at 23 degrees C in the presence of 1% kerosene or 0.3% palmitic, stearic, oleic, or linoleic acids.
Quantification of immune cells in the colon of DSS-treated mice. (2015)

<p>Numbers of T-cells, regulatory T-cells, and neutrophils in the colon of DSS-treated wt mice and mice lacking TLR2 and/ or TLR4. The average number of cells positive for CD3, FOXP3, or myeloperoxidase from at least five high power fields (HPF, 400×magnification) per animal were determined microscopically in immunostained colon sections of wt mice (WT), and animals lacking TLR2 (TLR2<sup>-/-</sup>), TLR4<sup>-/-</sup> (TLR4<sup>-/-</sup>), or both (TLR2/4<sup>-/-</sup>) at day eight after DSS-treatment for seven days (C, grey circles). Healthy animals served as controls (H, white circles). The numbers of analyzed animals are given in parenthesis. Mean values (black bars), and significance levels (as compared to wt animals with colitis) determined by Student's t-test are indicated (<sup>*</sup>, <i>P</i><0.05;<sup> **</sup>, <i>P</i><0.01; <sup>***</sup>, <i>P</i><0.001).</p>
Directional light scanning 3-D display (2009)

This paper presents a new Three-Dimensional display method, so called Directional Light Scanning 3D display. By using holographic screen as a beam scanner and high frame rate Spatial Light Modulator (SLM), this method requires only one SLM but can display high resolution 3D images, solving the usual problem of lack of resolution.
Genetic typing of alpha1-antitrypsin by immunofixation electrophoresis, identification of subtypes of Pi M. (1976)

Prolonged electrophoresis in alkaline agarose gels, followed by immunofixation, is a valuable addition to acid starch gel electrophoresis and isoelectric focusing for the genetic phenotyping of alpha1-antitrypsin. This technique is helpful in clarifying certain variants and in ascertaining types in serum and amniotic fluid samples with secondary changes. In addition, heterogeneity may be detected within the variants found at pH 4.95, analogous to hemoglobin polymorphism. Two "new" variants, PiMLamb and PiMBaldwin, have been detected by a combination of immunofixation electrophoresis and acid starch gel electrophoresis.
Influence of culture time on the expression of drug‐metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2 (2003)

Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug-metabolizing enzymes in these in vitro models, expression of genes coding for several cytochrome P450 isoforms and phase II enzymes was quantified during culture time by real-time RT-PCR. Gene expression was determined daily for primary hepatocytes maintained in a sandwich culture over 1 week and for HepG2, during the first 10 passages. In primary hepatocytes characteristic expression trends were observed which could be abstracted into three major classes of time curves. Genes of the first and the second class had an expression maximum around day 6 and day 4 in culture, respectively. The third class of genes had two expression peaks: at day 1 and 5 in culture. Surprisingly, also the cell line HepG2 showed significant expression changes during passages. For example, gene expression of cytochrome 1A1 varied 8-fold, that of cytochrome 2B6 30-fold, and that of NADP-quinone reductase 1 more than 200-fold within the first 10 passages. In conclusion, neither primary hepatocytes nor HepG2 cell line display a model for constant expression of drug-metabolizing enzymes.
Polyvinylpyrrolidone-Based Coatings for Polyurethanes – The Effect of Reagent Concentration on Their Chosen Physical Properties (2012)

A method of manufacturing hydrogel coatings designed to increase the hydrophilicity of polyurethanes (PU) is presented. Coatings were obtained from polyvinylpyrrolidone (PVP) by free radical polymerisation. The authors proposed a mechanism of a two-step grafting - crosslinking process and investigated the influence of reagent concentration on the coating’s physical properties - hydrogel ratio ( HG ) and equilibrium swelling ratio ( ESR ). A surface analysis of freeze-dried coatings using scanning electron microscopy (SEM) showed a highly porous structure. The presented technology can be used to produce biocompatible surfaces with limited protein and cell adhesive properties and can be applied in fabrication of number of biomedical devices, e.g. catheters, vascular grafts and heart prosthesis.
Low-cost PCB antenna for UWB applications (2005)

This letter presents a low-cost knight's helm shape double-sided printed circuit board (PCB) antenna of size 3 cm/spl times/3 cm for ultra-wideband (UWB) application. The antenna has a return loss of more than 10 dB, constant group delay and gain flatness over the frequency range set by the Federal Communications Commission (FCC) for UWB application. Satisfactory performance was obtained using FR4 substrate, allowing low cost of production. This letter also addresses the experimental measurements of group delay and impulse response, which are commonly overlooked.
Meniscal repairs: proven techniques and current trends (2002)

Preservation of meniscal cartilage is a key factor in maintaining a healthy knee. The successful repair of a torn meniscus has become the standard of care when dealing with meniscal tears. Pioneering techniques in arthroscopic-assisted meniscal repair have withstood the test of time and have become the standard for successful repair. The vertical suture-loop is the standard by which all repairs are measured. A number of new arthroscopic implants are available, which are attractive in their simplicity. There is little, if any, literature that substantiates this progressive trend. If used appropriately, these implants have the potential for improving our current techniques in achieving successful meniscal repair.
Enhanced tumor specificity of 741F8-1 (sFv')2, an anti-c-erbB-2 single-chain Fv dimer, mediated by stable radioiodine conjugation. (1995)

These observations may have clinical relevance for the use of radiolabeled sFv as imaging agents.
Environmental Problems in Search of Analytical Solutions (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnvironmental Problems in Search of Analytical SolutionsAlan R. NewmanCite this: Anal. Chem. 1990, 62, 15, 847A–849APublication Date (Print):August 1, 1990Publication History Published online30 May 2012Published inissue 1 August 1990https://doi.org/10.1021/ac00214a742RIGHTS & PERMISSIONSArticle Views23Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Synthesis of 2′‐<i>O</i>‐[(Triisopropylsilyl)oxy]methyl (= tom)‐Protected Ribonucleoside Phosphoramidites Containing Various Nucleobase Analogues (2005)

Abstract The first results of a study aiming at an efficient preparation of a large variety of 2′‐ O ‐[(triisopropylsilyl)oxy]methyl(= tom)‐protected ribonucleoside phosphoramidite building blocks containing modified nucleobases are reported. All of the here presented nucleosides have already been incorporated into RNA sequences by several other groups, employing 2′‐ O ‐tbdms‐ or 2′‐ O ‐tom‐protected phosphoramidite building blocks (tbdms = ( tert ‐butyl)dimethylsilyl). We now optimized existing reactions, developed some new and shorter synthetic strategies, and sometimes introduced other nucleobase‐protecting groups. The 2′‐ O ‐tom, 5′‐ O ‐(dimethoxytrityl)‐protected ribonucleosides N 2 ‐acetylisocytidine 5 , O 2 ‐(diphenylcarbamoyl)‐ N 6 ‐isobutyrylisoguanosine 8 , N 6 ‐isobutyryl‐ N 2 ‐(methoxyacetyl)purine‐2,6‐diamine ribonucleoside (= N 8 ‐isobutyryl‐2‐[(methoxyacetyl)amino]adenosine) 11 , 5‐methyluridine 13 , and 5,6‐dihydrouridine 15 were prepared by first introducing the nucleobase protecting groups and the dimethoxytrityl group, respectively, followed by the 2′‐ O ‐tom group ( Scheme 1 ). The other presented 2′‐ O ‐tom, 5′‐ O ‐(dimethoxytrityl)‐protected ribonucleosides inosine 17 , 1‐methylinosine 18 , N 6 ‐isopent‐2‐enyladenosine 21 , N 6 ‐methyladenosine 22 , N 6 , N 6 ‐dimethyladenosine 23 , 1‐methylguanosine 25 , N 2 ‐methylguanosine 27 , N 2 , N 2 ‐dimethylguanosine 29 , N 6 ‐(chloroacetyl)‐1‐methyladenosine 32 , N 6 ‐{{{(1 S ,2 R )‐2‐{[(tert‐butyl)dimethylsilyl]oxy}‐1‐{[2‐(4‐nitrophenyl)ethoxy]carbonyl}propyl}amino}carbonyl}}adenosine 34 (derived from L ‐threonine) and N 4 ‐acetyl‐5‐methylcytidine 36 were prepared by nucleobase transformation reactions from standard, already 2′‐ O ‐tom‐protected ribonucleosides ( Schemes 2–4 ). Finally, all these nucleosides were transformed into the corresponding phosphoramidites 37 – 52 ( Scheme 5 ), which are fully compatible with the assembly and deprotection conditions for standard RNA synthesis based on 2′‐ O ‐tom‐protected monomeric building blocks.
A study of the rainfall distribution of the unprecedented September 1978 floods in West Bengal with particular reference to the contribution from Damodar catchment (1983)

The flood in West Bengal during the last week of September 1978 has a special significance in the annals of floods in West Bengal due to the havoc it caused in terms of widespread destruction and tremendous loss of life and property in an unprecedented magnitude. A study has been made to indicate the synoptic Meteorological condition associated with this very heavy rainfall in West Bengal and the rainfall distribution during this rainspell. The contributions to the inflow from the Damodar valley area has also been indicated. A comparison with the highest flood in the last five or six decades prior to 1978 has also been made.
The benefit of detergent enzymes under changing washing conditions (1983)

Abstract The influence of two commercial proteolytic enzymes, Maxatase® and PB‐92, were studied viz á viz changing phosphate content and washing conditions. (Maxatase® is a registered trademark of Gist‐Brocades N.V.; PB‐92 will be sold under the trademark Maxacal TM .) In the USA and Western Europe, detergent phosphate content is decreasing because of environmental considerations/legislation. Washing conditions are changing towards lower temperatures be‐cause of the increased use of synthetic fibers and the need to con‐serve energy. Both Maxatase and PB‐92 are shown to improve sig‐nificantly the performance of US detergents, even at temperatures as low as 70 F. This conclusion is based on Terg‐O‐Tometer tests on EMPA 116 cloth using US detergents and presoak products.
A Newton method for canonical Wiener-Hopf and spectral factorization of matrix polynomials (2013)

The paper presents a novel Newton method for constructing canonical Wiener-Hopf factorizations of complex matrix polynomials and spectral factorizations of positive definite matrix polynomials. The factorizations are the ones needed for discrete-time linear systems and hence with respect to the unit circle. The Jacobi matrix is analyzed, and the convergence of the method is proved and tested numerically. A new class of highly ill-conditioned test polynomials is introduced, and the method is shown to manifest its very good performance also in this critical setting.
Operational testing of sediment microbial fuel cells in San Diego Bay (2010)

In-situ testing has been conducted to evaluate the output power of sediment-based microbial fuel cell prototypes. Prototypes have been developed, by the Naval Research Lab (NRL) and Oregon State University (OSU), to power a hydrophone that is used by the Navy to track pacific green sea turtles in San Diego Bay. The NRL MFC anode consisted of a graphite anode buried in anaerobic sediment. The OSU MFC anode consisted of a carbon fiber anode inside a chamber that created a seal with the sediment. Both systems had a carbon fiber cathode floating in the water column. Each fuel cell trickle charged a rechargeable battery which provided power to the hydrophone. The MFC designed by NRL generated up to 60 mW of power and powered the hydrophone for a three month period of time. A miniature MFC was developed that evaluated the power potential of sediment and determined the optimal deployment sites for MFC systems.
Immunocytochemical localization of sulfated glycoprotein‐1 (SGP‐1) and identification of its transcripts in epithelial cells of the extratesticular duct system of the rat (1992)

The localization of sulfated glycoprotein-1 (SGP-1) in the extratesticular duct system was analyzed using an affinity purified antibody raised against the protein in conjunction with light (LM) and electron (EM) microscope immunocytochemistry. In the LM an intense immunoperoxidase reaction product was observed over the cytoplasm of Sertoli cells as well as over the tails of late spermatids. The rete epithelial cells and nonciliated cells of the efferent ducts also showed an intense uniform reaction over their entire cytoplasm. In the EM, immunogold labeling was noted over the entire endocytic apparatus of these cells including coated pits, endosomes, multivesicular bodies, and secondary lysosomes. Since there was no labeling of the luminal contents including sperm along the epididymis, it was concluded that the Sertoli-derived SGP-1 must dissociate from the sperm and be taken up by epithelial cells at the level of the rete testis and efferent ducts. In all regions of the epididymis, except the cauda, the principal cells showed, in the LM, an intense reaction over bodies of various shapes and sizes in their supranuclear region; this corresponded in the EM to a strong immunogold labeling of secondary lysosomes. No labeling was noted, however, over coated pits, endosomes, or pale multivesicular bodies, suggesting that SGP-1 was not being endocytosed from the lumen. Similar observations were noted for the epithelial clear cells along the entire epididymis. In the cauda epididymidis, principal cells presented a weak immunolabeling of their secondary lysosomes. Northern blot analysis revealed a strong 2.6 Kb band corresponding to the mRNA of SGP-1 in the efferent ducts and all regions of the epididymis with the exception of the cauda. Coincident with the mRNA expression of SGP-1 it was found that small clusters of gold particles representing anti SGP-1, presumably membrane bound, were associated with the Golgi apparatus as well as in close proximity to secondary lysosomes. There was, however, no evidence for the secretion of SGP-1 into the lumen. These results suggest that SGP-1 is synthesized by the epithelial cells of the male duct system and ferried by small vesicles derived from the Golgi apparatus to secondary lysosomes. Because SGP-1 has recently been shown to have substantial sequence similarity to prosaposin, it may be speculated that SGP-1 is instrumental in the degradation of membrane glycolipids present within secondary lysosomes of epithelial cells of the extratesticular duct system.
Cooperative Relay for Cognitive Radio Networks (2009)

Cognitive radio has been proposed in recent years to promote the spectrum utilization by exploiting the existence of spectrum holes. The heterogeneity of both spectrum availability and traffic demand in secondary users has brought significant challenge for efficient spectrum allocation in cognitive radio networks. Observing that spectrum resource can be better matched to traffic demand of secondary users with the help of relay node that has rich spectrum resource, in this paper we exploit a new research direction for cognitive radio networks by utilizing cooperative relay to assist the transmission and improve spectrum efficiency. An infrastructure-based secondary network architecture has been proposed to leverage relay-assisted discontiguous OFDM (D-OFDM) for data transmission. In this architecture, relay node will be selected which can bridge the source and the destination using its common channels between those two nodes. With the introduction of cooperative relay, many unique problems should be considered, especially the issue for relay selection and spectrum allocation. We propose a centralized heuristic solution to address the new resource allocation problem. To demonstrate the feasibility and performance of cooperative relay for cognitive radio, a new MAC protocol has been proposed and implemented in a Universal Software Radio Peripheral (USRP)-based testbed. Experimental results show that the throughput of the whole system is greatly increased by exploiting the benefit of cooperative relay.
The U.S. Position (1979)

Journal Article The U.S. Position Get access Glen O. Robinson Glen O. Robinson 1Professor in the School of Law, the University of Virginia, and head of the U.S. delegation to the World Administrative Radio Conference Search for other works by this author on: Oxford Academic Google Scholar Journal of Communication, Volume 29, Issue 1, March 1979, Pages 150–157, https://doi.org/10.1111/j.1460-2466.1979.tb01695.x Published: 07 February 2006
Cefotetan Disodium-Induced Hemolytic Anemia (1992)

Cefotetan should be added to the list of drugs known to cause hemolytic anemia. Monitoring for hemolysis should be considered for patients who receive multiple courses of therapy.
A highly-linear CMOS RF programmable-gain driver amplifier with a digital-step differential attenuator for RF transmitters (2013)

This paper presents a CMOS RF programmable-gain driver amplifier (RF PGDA) for wireless transmitters. Digital-step differential attenuators precede a programmable-gain amplifier in order to enhance the dynamic range and to save power consumption, especially at low gain region. The RF PGDA fabricated in 0.13-μm CMOS technology with a 1.2 V supply voltage achieves a dynamic range of 49 dB with a step error of less than 0.5 dB and highly-linearized output satisfying the WCDMA/LTE specifications.
Transcriptional suppression of the human T-cell leukemia virus type I long terminal repeat occurs by an unconventional interaction of a CREB factor with the R region. (1994)

To analyze regulation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR), cell lines were generated from LTR-tax x LTR-beta-galactosidase (beta-Gal) doubly transgenic mouse fibroblastic tumors. The HTLV-I LTR directs expression of both the tax and lacZ genes, and Tax up-modulates both promoters in primary cells. However, once cells were transformed by tax, beta-Gal but not tax expression was suppressed. Supertransformation of these cells with v-src suppressed both beta-Gal and tax expression. This suppression was reversed by treatment with the tyrosine kinase inhibitor herbimycin A or protein kinase A inhibitor H8. Electrophoretic mobility shift assays demonstrated augmented binding in the R but not U3 region. This binding was competitively inhibited by a high-affinity CREB oligodeoxynucleotide and super-shifted with a specific CREB antibody. Treatment of cells with the cyclic AMP analog dibutyryl cyclic AMP also transiently increased the R region binding dramatically. In vitro DNase I footprint analysis identified a protein-binding sequence in the R region which corresponded with suppression. However, this target sequence lacked a conventional CREB-binding site. A 70.5-kDa DNA-binding protein was partially purified by affinity chromatography, along with a 49-kDa protein which reacted with CREB-specific sera. These data demonstrate that HTLV-I LTR suppression is associated with CREB factor binding in the R region, probably by direct interaction with a 70.5-kDa protein, and provide a novel mechanism for maintenance of viral latency.
Improving SS7 Security Using Machine Learning Techniques (2016)

The Signaling System No. 7 is the nervous system of telecommunication networks based on 2G and 3G technologies. Previously confined in a walled garden, SS7 has become more exposed due to increased liberalization of the market in conjunction with the industry switching to IP technology. In the walled garden of trusted operators, security have received minimal attention. SS7 has become more vulnerable in the recent years, with attackers exploiting network communications to track subscribers, intercept calls, perform denial of services, and commit fraud. This master thesis is a part of the effort to reduce the vulnerabilities contained in the old, yet crucial protocols that the telecommunication operators cannot function without. Subscribers, operators, and national governments are dependent on one of societies critical infrastructures, it needs to be adequately protected. In this thesis, a detailed overview of SS7 threats and vulnerabilities is presented. In an effort to mitigate these attacks, open source technology has been used to simulate network traffic. This generated traffic were used to analyse and detect attacks against SS7 in an effort to propose detection mechanisms. Machine learning, big data, and anomaly detection techniques have been used as tools in order to propose an improved online protection system for SS7 networks. The results achieved in this master’s thesis have been submitted in the form of a paper to the International Conference on IT Convergence and Security 2016, Appendix A presents the submitted paper in its current form.
Cerebral Vascular Dysfunction Mediated by Superoxide in Hyperhomocysteinemic Mice (2004)

Superoxide is a key mediator of endothelial dysfunction in the cerebral circulation during diet-induced hyperhomocysteinemia.