gebhart/patrepeval huggingface dataset:
Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIA (1973)

To assess the genetics of hyperlipidemia in coronary heart disease, family studies were carried out in 2520 relatives and spouses of 176 survivors of myocardial infarction, including 149 hyperlipidemic and 27 normolipidemic individuals. The distribution of fasting plasma cholesterol and triglyceride values in relatives, together with segregation analyses, suggested the presence of five distinct lipid disorders. Three of these-familial hypercholesterolemia, familial hypertriglyceridemia, and familial combined hyperlipidemia-appeared to represent dominant expression of three different autosomal genes, occurring in about 20% of survivors below 60 yr of age and 7% of all older survivors. Two other disorders-polygenic hypercholesterolemia and sporadic hypertriglyceridemia-each affected about 6% of survivors in both age groups. The most common genetic form of hyperlipidemia identified in this study has hitherto been poorly defined and has been designated as familial combined hyperlipidemia. Affected family members characteristically had elevated levels of both cholesterol and triglyceride. However, increased cholesterol or increased triglyceride levels alone were also frequently observed. The combined disorder was shown to be genetically distinct from familial hypercholesterolemia and familial hypertriglyceridemia for the following reasons: (a) the distribution pattern of cholesterol and triglyceride levels in relatives of probands was unique; (b) children of individuals with combined hyperlipidemia did not express hypercholesterolemia in contrast to the finding of hypercholesterolemic children from families with familial hypercholesterolemia; and (c) analysis of informative matings suggested that the different lipid phenotypes owed their origin to variable expression of a single autosomal dominant gene and not to segregation of two separate genes, such as one elevating the level of cholesterol and the other elevating the level of triglyceride. Heterozygosity for one of the three lipid-elevating genes identified in this study may have a frequency in the general population of about 1%, constituting a major problem in early diagnosis and preventive therapy.
Low cost parallel-to-serial converter for digital instrumentation (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow cost parallel-to-serial converter for digital instrumentationMorteza. Janghorbani, John A. Starkovich, and Harry. FreundCite this: Anal. Chem. 1971, 43, 3, 493–495Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/ac60298a045https://doi.org/10.1021/ac60298a045research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biosynthesis of new polymers of controlled molecular structure (1992)

Abstract This paper describes the use of artificial genes to direct bacterial synthesis of new polypeptides of precisely defined molecular structure. This approach has been applied to three problems in polymer chemistry and physics: i) control of chain folding in crystalline polymers, ii) biosynthesis of polypeptides containing unnatural amino acids, and iii) preparation of monodisperse helical polymers.
Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue (2008)

Two additional healthy children have been born as a result of the ovarian cryopreservation procedure. In both cases, the ovarian tissue was transported 4-5 h prior to freezing demonstrating that hospitals may offer cryopreservation without having the necessary expertise locally.
ChemInform Abstract: TRIFLAMIDES (CF3SO2N=), A SURVEY (1973)

Im Rahmen einer Übersicht über das Verhalten der Titelverbindungen bei Substitutions- und Eliminierungsreaktionen wird die Darstellung der Acylderivate (III) aus dem Sulfonamid (I) und den Säurechloriden (II) in Methylenchlorid in Gegenwart von Triäthylamin beschrieben.
Indoles Synthesized from Amines via Copper Catalysis (2013)

N-substituted indoles are synthesized from primary amines through a tandem reaction sequence. Initial condensation of the amine with an α-(o-haloaryl)ketone or aldehyde is followed by intramolecular aryl amination catalyzed by CuI. A variety of anilines and alkyl amines, including those with significant steric demands, are converted to indoles in high yields and with varying indole substitution.
A β-Naphthaleneimide-Modified Terthiophene Exhibiting Charge Transfer and Polarization Through the Short Molecular Axis. Joint Spectroscopic and Theoretical Study (2008)

We present a new terthiophene derivative substituted at the thienyl beta positions with a naphthalenediimide functionalization. The UV-vis absorption and emission spectroscopic properties as well as the electrochemical properties have been discussed to describe its electronic structure. The vibrational Raman data are used to inspect the molecular architecture. All of the experimental data are supported by quantum chemical calculations with different approaches. A close comparison with other terthiophenes available in the literature is conducted, always stressing the effect of the relative orientation of the donor and acceptor groups either with long-axis or short-axis polarizations. The electronic structure of the molecule has been understood in terms of the HOMO-LUMO absolute energy values. A considerable reduction of the band gap from the constituting units to the studied molecule is detected, although electronic interaction is not optimal for this configuration. Fluorescence quenching is interpreted by the possibility of intersystem crossing and internal conversion. Finally, Raman spectroscopy gives additional information of the distribution of conjugation along the molecular domain, of subtle conformational effects, and of the intermolecular interaction by means of temperature-dependent Raman data. This study provides guidelines for controlling the electronic structure and for exploring new strategies pursuing improved dyes.
Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system (1994)

The wild-type tumor suppressor protein p53 is a short-lived protein that plays important roles in regulation of cell cycle, differentiation, and survival. Mutations that inactivate or alter the tumor suppressor activity of the protein seem to be the most common genetic change in human cancer and are frequently associated with changes in its stability. The ubiquitin system has been implicated in the degradation of p53 both in vivo and in vitro. A mutant cell line that harbors a thermolabile ubiquitin-activating enzyme, E1, fails to degrade p53 at the nonpermissive temperature. Studies in cell-free extracts have shown that covalent attachment of ubiquitin to the protein requires the three conjugating enzymes: E1, a novel species of ubiquitin-carrier protein (ubiquitin-conjugating enzyme; UBC),E2-F1, and an ubiquitin-protein ligase, E3. Recognition of p53 by the ligase is facilitated by formation of a complex between the protein and the human papillomavirus (HPV) oncoprotein E6. Therefore, the ligase has been designated E6-associated protein (E6-AP). However, these in vitro studies have not demonstrated that the conjugates serve as essential intermediates in the proteolytic process. In fact, in many cases, conjugation of ubiquitin to the target protein does not signal its degradation. Thus, it is essential to demonstrate that p53-ubiquitin adducts serve as essential proteolytic intermediates and are recognized and degraded by the 26S protease complex, the proteolytic arm of the ubiquitin pathway. In this study, we demonstrate that conjugates of p53 generated in the presence of purified, E1, E2, E6-AP, E6, ubiquitin and ATP, are specifically recognized by the 26S protease complex and degraded. In contrast, unconjugated p53 remains stable. The ability to reconstitute the system from purified components will enable detailed analysis of the recognition process and the structural motifs involved in targeting the protein for degradation.
Cleavage of the Phosphate Diester Backbone of DNA with Cerium(III) and Molecular Oxygen (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCleavage of the Phosphate Diester Backbone of DNA with Cerium(III) and Molecular OxygenBryan K. Takasaki and Jik ChinCite this: J. Am. Chem. Soc. 1994, 116, 3, 1121–1122Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ja00082a040https://doi.org/10.1021/ja00082a040research-articleACS PublicationsRequest reuse permissionsArticle Views483Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Large Diameter Pipe under Combined Loading (1973)

The writers consider the planning and performance of a full-scale test program on 30 ft. long, 4 ft. diam pipe sections. The combined loadings applied in these tests simulate the force and displacements anticipated to be introduced in the underground portion of the trans-Alaska pipeline under service conditions. Experimental results are presented, and a comparison with theoretical data are included.
Expanding the Group of Porous Interpenetrated Zr-Organic Frameworks (PIZOFs) with Linkers of Different Lengths (2016)

A Zr-based MOF of the PIZOF type, which consists of two independent and mutually interpenetrating UiO-type frameworks with [Zr<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>(O<sub>2</sub>C)<sub>12</sub>] nodes, does not only form with a PEPEP dicarboxylic acid (P = phenylene, E = ethynylene). Also dicarboxylic acids with the shorter PPPP and PEPP spacers were found to give PIZOFs, denoted PPPP-PIZOF and PEPP-PIZOF, respectively. Reducing the spacer length even further to a PEEP segment caused a switchover to the formation of a UiO framework. The hysteresis in the Ar sorption curve of PEPP-PIZOF-1 and the slightly too large amount of combustion residue from PPPP-PIZOF-1 suggest structural defects. These hint at a mismatch between the requirement of the optimal linker length for PIZOF formation and the lengths of the PEPP and PPPP dicarboxylates. Nevertheless, these dicarboxylates prefer the formation of a PIZOF over the formation of a UiO structure. PEPEP-PIZOF-2, PPPP-PIZOF-1, and PEPP-PIZOF-1 are stable in air up to 325, 350, and 300 °C, respectively, and have BET surface areas of 2350, 2020, and 1650 m<sup>2</sup> g<sup>-1</sup>, respectively. PEPEP-PIZOFs, even those with very hydrophilic oligo(ethylene glycol) side chains on the linkers, are very stable in water and also during drying from a water-wetted state. On the contrary, PEPP-PIZOF-1 and PPPP-PIZOF-1 that had been exposed to water required exchange of water for ethanol before drying to mostly preserve the framework. The results emphasize the importance of differentiating between framework damage caused through hydrolysis in water and through drying from a water-wetted state. The sensitivity of PEPP-PIZOF-1 and PPPP-PIZOF-1 against drying from a water-wetted state may be the consequence of defects. The drying stability of water-wetted PEPEP-PIZOFs lets us suggest that reversible bending of the linkers contributes to the stability of the PEPEP-PIZOFs.
Impact of Chronic Neonicotinoid Exposure on Honeybee Colony Performance and Queen Supersedure (2014)

Sublethal neonicotinoid exposure did not provoke increased winter losses. Yet, significant detrimental short and long-term impacts on colony performance and queen fate suggest that neonicotinoids may contribute to colony weakening in a complex manner. Further, we highlight the importance of the genetic basis of neonicotinoid susceptibility in honeybees which can vary substantially.
Head of gold, feet of clay: The online learning paradox (2011)

Although online learning (OL) is becoming widely accessible and is often viewed as cutting-edge, the actual number of regular faculty participating in this form of teaching remains small. Moreover, OL, despite its growing recognition, is often associated with high rates of student dissatisfaction and isolation, withdrawal, and attrition. Furthermore, although administrators typically champion support of OL, they often seem unable or unwilling to marshal the necessary financial, human, and technological resources to produce high-quality course materials and to effect efficient course delivery. In short, online learning seems paradoxically to be both booming and busting simultaneously. It is expanding supply yet hitting similar obstacles that distance education encountered generations earlier. Under these circumstances, OL is unlikely to become mainstream without a major redirection. This article applies economic principles and concepts to OL. The revised conceptualization posits that an understanding of stakeholder priorities is the key to improved online course design and delivery.<input id="gwProxy" type="hidden" /><input id="jsProxy" onclick="if(typeof(jsCall)=='function'){jsCall();}else{setTimeout('jsCall()',500);}" type="hidden" /><input id="gwProxy" type="hidden" /><input id="jsProxy" onclick="if(typeof(jsCall)=='function'){jsCall();}else{setTimeout('jsCall()',500);}" type="hidden" />
Effect of Iron-Oxidizing Bacteria on Pitting of Stainless Steel (2004)

Microbiologically influenced corrosion (MIC) of stainless steel (SS) can be caused by the action of metal-oxidizing bacteria (MOB) in natural, relatively low-chloride waters. This type of corrosion is frequently associated with ennoblement of the open-circuit potential and involves iron-oxidizing bacteria (IOB) and manganese-oxidizing bacteria (MnOB). This work focuses of the role of IOB and associated inorganic water chemistry processes that may cause corrosion of SS. Laboratory and field studies have been conducted to investigate the influence of deposited ferric oxide (or oxyhydroxide) on the corrosion of UNS S30403. Samples exposed to a natural spring water reached open-circuit potentials of 250 mV vs saturated calomel electrode (SCE) and were covered by a biofilm containing a mixture of geothite (α-FeOOH), lepidocrocite (γ-FeOOH), and magnetite (Fe3O4) or maghemite (γ-Fe2O3), together with low levels of manganese-based deposits. In the laboratory, an iron-based film was formed on some samples by oxidation of ferrous sulfate (FeSO4) with calcium hypochlorite (Ca[ClO]2), giving a surface film with a composition similar to that produced by microbial activity. These samples did not show ennoblement, but they did show lower pitting potentials than were measured for control samples. The results of this work are consistent with the idea that MIC of SS in potable water involves manganese-based deposits causing ennoblement (W.H. Dickinson, F. Caccavo Jr., Z. Lewandowski, Corros. Sci. 38 [1996], p. 1,407), combined with iron-based deposits simultaneously causing a decrease in the pitting potential (M. Suleiman, I. Ragault, R. Newman, Corros. Sci. 36 [1994], p. 479).
Wafer Stress Durinlg Rapid Thermal Annealing Due to Surface Geometrical Patterns (1985)

Rapid thermal annealing with tungsten-halogen lamps has been utilized in the VLSI fabrication process to minimize dopant redistribution (Ref.1). Due to radiative and non-equilibrium heat transfer, heating and cooling rates for silicon wafers depend on surface radiative characteristics. If an emissivity difference exists on a wafer surface, temperature gradient and thermal stress would be generated. They could result in crystal dislocation and device performance degradation.
Cheek swabs, SNP chips, and CNVs: Assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray (2012)

We observed performance from the subject-collected mail-in buccal brush samples comparable to that of blood. These results show that such DNA samples can be used for genome-wide scans of both SNPs and CNVs, and that high rates of CNV concordance were achieved whether using a change-point-based algorithm or one based on a hidden Markov model (HMM).
Salvia miltiorrhiza monomer IH764-3 induces hepatic stellate cell apoptosis<i>via</i>caspase-3 activation (2002)

Within the dose range used in present study IH764-3 can inhibit HSC proliferation as well as enhance HSC apoptosis. Furthermore IH764-3 can significantly increase the caspase-3 protein expression.
Thin Film Phase Behavior of Bottlebrush/Linear Polymer Blends (2014)

Bottlebrush polymers contain polymeric side-chains attached to a linear polymer backbone, and they are currently of interest for a variety of potential applications that include drug delivery, tailored surface wettability, and self-assembled photonics. These polymers are challenging to synthesize in large quantities, so for practical applications, it is of interest to study their properties as additives for low-cost linear polymers. In this work, we examine the phase behavior of bottlebrush polystyrene (PS) and linear deuterated polystyrene (dPS) in thin films. These nearly athermal systems exhibit wetting and dewetting transitions that drive bottlebrush dispersion or aggregation, respectively, and these effects depend on the relative degrees of polymerization of matrix chains Nm to those of bottlebrush side-chains Nsc. When Nm/Nsc is low (≤1.6), the bottlebrushes are dispersed throughout the film thickness with a slight excess at the free surface and substrate interfaces. When Nm/Nsc is high (≥8), the bottlebrushes are depleted from the interior of the film and strongly segregated at the interfaces. The interfacial excess is driven by an entropic depletion attraction effect: larger branched molecules are adsorbed (attracted) to the interfaces, and the linear chains are displaced to the film’s interior where they gain conformational entropy. The bottlebrushes prefer to accumulate at the silicon substrate over the air interface, and this may be driven by the more restrictive condition of a hard boundary or weak van der Waals interactions with the underlying silicon. These studies demonstrate that low concentrations of certain bottlebrush polymer architectures can generate brushlike surfaces and interfaces in any thermoplastic material through a spontaneous, entropy-driven segregation process.
Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse (1992)

We have recently cloned and characterized a novel embryonic alkaline phosphatase (EAP) expressed at the two-cell to blastocyst stage of preimplantation development in the mouse. The isozyme is re-expressed in trace amounts in the thymus, intestine and testis during adult life. In the present report, we find that EAP transcripts can be detected, by RT-PCR analysis, in very low amounts in the testes of newborn mice, but at 24 days of age EAP mRNA levels reach the highest concentrations, remaining high at 40 and even 117 days of age. We produced a synthetic peptide and a corresponding rabbit anti-peptide antiserum (Rb-1434), which was characterized by enzyme antigen immunoassays and reactivity with chinese hamster ovary cell transfectants, as reacting specifically with EAP. The Rb-1434 antibody enabled us to examine immunohistochemically what cell types in the testis are responsible for the expression of EAP during different developmental stages. No positive cells were recognized in the testis of newborns (day 0) and 8-day-old mice. Positive cells were first observed at day 15 and, at 24 days of age, many positive M-phase cells, morphologically corresponding to spermatocytes in mid to late prophase of meiotic division I, were strongly positive for EAP expression. Positive M-phase cells were also observed at 40 days and 151 days of age. Transgenic mice expressing the human GCAP isozyme in a tissue-specific manner in the testis, showed equivalent stages of M-phase figures when stained immunohistochemically with a specific rabbit polyclonal antiserum.(ABSTRACT TRUNCATED AT 250 WORDS)
GIII-facsimile adapter for cellular mobile telephone using error control scheme (2002)

An adaptive error control scheme suitable for mobile communication systems id described. An error-free high-speed data modem that uses an adaptive error control scheme is developed. Utilizing the error-free modem for which the error control scheme is adapted, a facsimile adapter which makes GIII-facsimile communication possible between a cellular mobile telephone and an office, and between two cellular mobile telephones, is developed. The error-free modem, a facsimile adapter as an example application of this modem, and modem LSIs which are developed for use in the signal converter unit of the error-free modem are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Differential kinematics of serial manipulators using virtual chains (2005)

This paper presents a new approach to calculate the direct and inverse differential kinematics for serial manipulators. The approach is an extension of the Davies method for open kinematic chains based on a virtual kinematic chain concept introduced in this paper. It is a systematic method that unifies the kinematics of serial manipulators considering the type of kinematics and the coordinate system of the operational space and constitutes an alternative way to solve the differential kinematics for manipulators. The usefulness of the method is illustrated by applying it to an industrial robot.