gebhart/patrepeval huggingface dataset:
AM1 study of the protonation of pteridine-related tetraazanaphthalenes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAM1 study of the protonation of pteridine-related tetraazanaphthalenesJulio Anguiano, Javier Fernandez Sanz, and Jaume VilarrasaCite this: J. Org. Chem. 1988, 53, 17, 3900–3903Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://doi.org/10.1021/jo00252a002Request reuse permissionsArticle Views85Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (515 KB) Get e-Alertsclose Get e-Alerts
Adsorption and Reaction of Methanol Molecule on Nickel Cluster Ions, Ni<i><sub>n</sub></i><sup>+</sup> (<i>n</i> = 3−11) (2000)

The reactions of methanol on a size-selected nickel cluster ion, Nin+ (n = 3−11), were investigated at collision energies less than 1.0 eV in a beam-gas geometry. Dominant reactions were methanol chemisorption, demethanation, and carbide formation. The absolute cross sections of these different reactions were measured and found to change dramatically with the cluster size; the demethanation proceeds preferentially on Ni4+, the carbide formation on Ni7,8+, and the chemisorption on Ni6+. A kinematic model explains the size-dependent characteristics that the chemisorption proceeds efficiently if the barrier height between the physisorbed and the chemisorbed states is low, and the demethanation and the carbide formation proceed otherwise. The rate of the carbide formation depends sensitively on an Ni−Ni distance of Nin+ so that it proceeds only on Ni7,8+.
A New Transformation of Silanols. Palladium-Catalyzed Cross-Coupling with Organic Halides in the Presence of Silver(I) Oxide (1999)

The reactions of aryl- and alkenylsilanols with organic halides are found to proceed in a catalyst system of 5 mol % of Pd(PPh3)4 and Ag2O (1 equiv) to give the corresponding coupling products in up to 84% yield.
REGULATION OF RETINOID X RECEPTOR‐γ GENE TRANSCRIPT LEVELS IN RAT HEART CELLS (1998)

Retinoid X receptor-gamma (RXRgamma) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life. However, its expression in embryonic and neonatal heart has not been investigated and it is not known whether ventricular cardiomyocytes express RXRgamma or whether all- trans -retinoic acid (tRA) and thyroid hormone (T3) could influence RXRgamma transcript levels in these cells. First, in situ hybridization experiments were used to test for any spatio-temporal correlation between RXRgamma gene expression and the previously shown requirement for retinoid signalling in embryonic ventricular cardiomyocytes. It was shown that RXRgamma transcripts are not detectable in embryonic heart at all developmental stages examined under conditions where they are detectable in other embryonic tissues. Second, Northern blotting was used to examine whether there is a difference in RXRgamma transcript levels between neonatal and adult heart. We show that levels of two RXRgamma transcripts are developmentally regulated during the postnatal period because they differ between neonatal and adult hearts. Third, it was demonstrated that primary cultures of neonatal rat ventricular cardiomyocytes express RXRgamma transcripts, making them a novel in vitro system for the study of RXRgamma gene regulation in heart-derived cells. Finally, this system was used to examine whether tRA and T3can influence levels of RXRgamma transcripts because they have been shown to have antagonistic effects in this system and to influence RXRgamma RNA levels in other systems. It was shown by Northern blot experiments, that in this system, RXRgamma transcript levels are differentially influenced by these two hormones. The significance of these findings in relation to previously published work is discussed.
Synthesis of highly functionalized 2‐(substituted biphenyl) benzimidzoles <i>via</i> suzuki‐miyaura cross coupling reaction (2007)

Abstract magnified image A facile and convenient method for the synthesis of highly functionalized 2‐(substitutedbiphenyl) based benzimidazoles has been reported by the application of Suzuki‐Miyaura cross coupling reaction.
Immigration Law and the Refugee--A Recommendation to Harmonize the Statutes With the Treaties (1975)

I would not read the law narrowly to make it the duty of our officials to send [an alien] . . . to what may be persecution or death.Technicalities need not enmesh us.The spirit of the law provides the true guide.It makes plain, I think, that . . .
Human soft tissue analysis using x-ray or gamma-ray techniques (2008)

This topical review is intended to describe the x-ray techniques used for human soft tissue analysis. X-ray techniques have been applied to human soft tissue characterization and interesting results have been presented over the last few decades. The motivation behind such studies is to provide improved patient outcome by using the data obtained to better understand a disease process and improve diagnosis. An overview of theoretical background as well as a complete set of references is presented. For each study, a brief summary of the methodology and results is given. The x-ray techniques include x-ray diffraction, x-ray fluorescence, Compton scattering, Compton to coherent scattering ratio and attenuation measurements. The soft tissues that have been classified using x-rays or gamma rays include brain, breast, colon, fat, kidney, liver, lung, muscle, prostate, skin, thyroid and uterus.
Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk (2003)

Hill, Jonathan M.; Zalos, Gloria; Halcox, Julian P. J.; Schenke, William H.; Waclawiw, Myron A.; Quyyumi, Arshed A.; Finkel, Toren
Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity (2019)

To overcome chemical limitations of camptothecin (CPT), we report design, synthesis, and validation of a quinoline-based novel class of topoisomerase 1 (Top1) inhibitors and establish that compound 28 ( N-(3-(1 H-imidazol-1-yl)propyl)-6-(4-methoxyphenyl)-3-(1,3,4-oxadiazol-2-yl)quinolin-4-amine) exhibits the highest potency in inhibiting human Top1 activity with an IC<sub>50</sub> value of 29 ± 0.04 nM. Compound 28 traps Top1-DNA cleavage complexes (Top1ccs) both in the in vitro cleavage assays and in live cells. Point mutation of Top1-N722S fails to trap compound 28-induced Top1cc because of its inability to form a hydrogen bond with compound 28. Unlike CPT, compound 28 shows excellent plasma serum stability and is not a substrate of P-glycoprotein 1 (permeability glycoprotein) advancing its potential anticancer activity. Finally, we provide evidence that compound 28 overcomes the chemical instability of CPT in human breast adenocarcinoma cells through generation of persistent and less reversible Top1cc-induced DNA double-strand breaks as detected by γH2AX foci immunostaining after 5 h of drug removal.
The Characterisation of the Static and Dynamic Drape of Fabrics (1997)

This paper discusses and establishes the static and dynamic drape of fabrics as an aesthetic property. A new algorithm is introduced, which defines more precisely the drapability of a given fabric. Experimental results show that it is more accurate to describe the different types of fabric-drape performance by using a feature vector, and this is found to be in good agreement with subjective assessment. A computer-based vision system, the Static- and Dynamic-drape-measurement System (M3), was developed and made possible the application of the new algorithm to actual fabric measurement. The results show agreement between aesthetic judgement and subjective assessment, and consequently fabric drape is standardised into four drape grades, ranging from high to low. The M3 is able to relate fabric drape with mechanical properties, simulating intelligence or expert knowledge when property change is needed for achieving a required drape performance.
A context-aware Multimodal Biometric Authentication for cloud-empowered systems (2016)

In the context of emerging technologies, Cloud Computing (CC) was introduced as a new paradigm to host and deliver Information Technology Services. In such an environment, privacy and security issues are critical areas that still require to be deeply explored. Yet, highly secured systems are generally met by computationally expensive systems. Such a system may also degrade the user experience and its willingness to adopt it. The aims of this paper are threefold: First, to integrate a Class-Association Rules (CARs) into the process of Multi-factor Authentication Based on Multimodal Biometrics (MFA-MB) for CC; Second, defines a new metric to measure the User Experience and; Third, exhibits an algorithm to authenticate cloud SaaS/PaaS Users with an enhanced MFA-MB scheme. Since, CARs are used to predict the most expected Multimodal Biometric Authentication (MBA) in the basis of Users' authentication habits, mined from their historical authentication data sets, which guarantees continuously improving their Experience. The integration of CARs in the CC authentication process allows also to identify the actual context (Time, Place, Device, etc.) which impacts the choice of biometrics used in MBA according to one User's situation. Therefore, this will help to increase the authentication security level using MBA at a decreased time and improved user experience. Integration of CARs is illustrated by a realistic case of Bimodal Biometric Authentication.
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl (2003)

Conventional cancer therapies are based on preferential killing of tumor cells by DNA damage. Previous work showed that, for certain cell types, loss of integrin-mediated adhesion decreased the apoptotic response to DNA damage because of decreased p53 levels after detachment from the extracellular matrix. Integrin ligation restored p53 and sensitivity to DNA damage. In this study, we show that c-Abl mediates a second pathway by which adhesion to extracellular matrix regulates cell killing by chemotherapeutic agents 5-arabinofuranosylcytosine, cisplatin, and camptothecin. Activation of c-Abl tyrosine kinase by DNA damage requires cell adhesion. Abl-dependent stabilization of p73, a p53-related proapoptotic transcription factor, is also adhesion-dependent. Sensitivity to the Abl inhibitor STI571 suggests differential utilization of the p53 and c-Abl/p73 pathways by different tumor cell lines. These data suggest that killing of p53-negative tumor cells by chemotherapy would be enhanced by integrin ligation to activate the alternative c-Abl/p73 pathway.
Empirical study of root cause analysis of software failure (2013)

Root Cause Analysis (RCA) is the process of identifying project issues, correcting them and taking preventive actions to avoid occurrences of such issues in the future. Issues could be variance in schedule, effort, cost, productivity, expected results of software, performance parameters and customer satisfaction. RCA also involves collecting valid data, analyzing it, deriving metrics and finding root causes using RCA methods. In this paper we will do Root cause analysis of some severe software failures that happened in the past and of some failures in ongoing projects in the software Industry. We will also describe various RCA methods and processes used in the software Industry to reduce the chances of software failure.
Administrative Law -- Power of Board of Education to Abolish Fraternities (1944)

Administrative Lawt
Free-space aberration-corrected gratingdemultiplexer for application in densely-spaced,subnanometre wavelength-routed optical networks (1995)

The operation of a free-space aberration corrected concave grating demultiplexer for applications in densely-spaced wavelength routed networks at 1.5 µm is described. Near-diffraction-limited performance in the wavelength range of 24 nm (over 60 channels) with channel spacing of 0.4 nm is reported for the first time.
Solubility in the Coatings Industry (1971)

The author's view of the solubility parameter is presented with practical suggestions for its use. The construction of solubility diagrams, the fitting of data, and guides for the most economical choice of solvent are given. Use of a relative solvent improvement efficiency factor for active solvents E=deltaA/Cost is suggested as an aid to reaching optimum conditions with a minimum of experimental effort.
Aerial Robotic Construction towards a New Field of Architectural Research (2012)

This paper takes a first step in characterizing a novel field of architectural research - aerial robotic construction (ARC) - where aerial robotics is used not only for construction, but as a guiding principle in the design and fabrication process. Featuring autonomous flying vehicles that lift small building elements and position them according to a precise digital blueprint, ARC offers a comprehensive new approach to architecture research and technology. Developed by the research groups of Gramazio & Kohler and Raffaello D'Andrea at ETH Zurich, ARC offers unique advantages over traditional approaches to building: it does not require scaffolding, it is easily scalable, and it offers digital integration and informational oversight across the entire design and building process. This paper considers 1) research parameters for the individual components of ARC (such as module design, connection methodologies, vehicle cooperation, and construction sequencing/synchronization), and 2) the architectural implications of integrating these discrete components into a systemic, unifying process at the earliest stages of design. Fidelity between the design concept and the full-scale construction is of particular concern.
PLASMA CATALYTIC REFORMING OF NATURAL GAS (1999)

In this paper, recent results of plasma processing of natural gas are described. The use of a plasma reformer for the generation of hydrogen rich gas from natural gas has been investigated. In an accompanying paper, progress in plasma reforming of diesel fuel is described. The reformate composition has been investigated as a function of the initial mixture of air and methane. High methane conversion, near 100%, was obtained at relatively low values of plasmatron power. Soon-to-be-implements improvements in the overall reformer, including multiple heat exchanger for efficient thermal management and multiple water shift reactors, are described. 1.
High-accuracy passive current balancing schemes for large-scale LED backlight system (2011)

In this paper, two high-accuracy low-cost current balancing circuits are proposed for LED backlight system by using capacitors and mini transformers. Compared with traditional active and passive balancing approaches, the proposed schemes greatly reduce cost and power losses, and achieve highly accurate current matching among all LED strings in wide dimming ranges. The current balancing principles of the proposed circuits are analyzed, and high accuracy designs are verified by simulation and experimental results.
T<scp>HE</scp> F<scp>LOW OF</scp> H<scp>UMAN</scp> C<scp>ROWDS</scp> (2002)

▪ Abstract The modern study of a crowd as a flowing continuum is a recent development. Distinct from a classical fluid because of the property that a crowd has the capacity to think, interesting new physical ideas are involved in its study. An appealing property of a crowd in motion is that the nonlinear, time-dependent, simultaneous equations representing a crowd are conformably mappable. This property makes many interesting applications analytically tractable. In this review examples are given in which the theory has been used to provide possible assistance in the annual Muslim Hajj, to understand the Battle of Agincourt, and, surprisingly, to locate barriers that actually increase the flow of pedestrians above that when there are no barriers present. Modern developments may help prevent some of the approximately two thousand deaths that annually occur in accidents owing to crowding.The field of crowd motion, that is, the field of “thinking fluids,” is an intriguing area of research with great promise.
New compounds: Structure of antitumor activity relationship study of B- and D-ring modified and non-modified steroidal esters of chlorambucil's active metabolite (2006)

547 Introduction: Nitrogen mustards are among the oldest and most extensively studied agents in human cancer chemotherapy. These drugs exert their biological activity by inducing interstrand cross-links in the major groove of DNA, which represents the most toxic of all alkylation events. Despite that only a small fraction forms effective cross-links due to their high inner chemical activity which results in their covalent binding to the nucleophilic sites of other biomolecules. Alternatively, simple mustards undergo rapid hydrolysis before reaching the DNA target. We have studied the effect of modification of the B-steroidal ring to lactamic on the antitumor potency of D-modified and D-non-modified steroidal esters of chlorambucil9s active metabolites. Materials and methods: In this study the pancreatic ductal adenocarcinoma PAN-02 was used. It was purchased from the NCI (USA). Tumor was grown in C57BL. The tumor was implanted subcutaneously with puncture in the inguinal region. The amount of the transplanted graft was 40-50 mg fragment. The acute toxicity of the compounds was determined and the lethal dose LD10 was used as a therapeutic dose. The antitumor activity was assessed from the inhibition of tumor growth by volume in cm3 and T/C%. Results and discussion: The toxicities of the compounds tested (PHE, 1A, 1B, 1C, 2A, 2B, 2C) are reported. The LD50 values of the steroidal esteric derivatives are higher than those of nitrogen mustard, showing that this conjugation reduces the cytotoxicity of the alkylating agent. From the results we can estimate that all esteric derivatives tested gave better TI% and T/C% values than the nitrogen mustard itself. Although the introduction of the allylic 7-keto group in the B-steroidal ring had impressive influence on the antitumor potency of the compounds tested (T/C% equal or higher of 70 % for all the oxidized compounds), similar results were not observed in the case of B-lactamic steroidal derivatives. The presence of the -NHCO moiety in the B-steroidal ring produced derivatives marginally active but at the same time were more toxic. This type of behavior offers additional support for the concept that this molecules produce their antitumor activity by binding at specific sites and that the steroidal moiety is not only a simple carrier for the nitrogen mustard.
A novel beam-splitting microscope tube for taking stereo-pairs with full resolution Nomarski or phase contrast technique, or with epifluorescence (1989)

A device is presented which for the first time allows stereo-pairs to be taken with full resolving power on a single frame, since both single views are formed by the complete diffraction image. The device can be introduced into the mononuclear tube of any light microscope.
<i>S,S</i>-Dimethyl Dithiocarbonate:  A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical Ureas (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTS,S-Dimethyl Dithiocarbonate: A Convenient Reagent for the Synthesis of Symmetrical and Unsymmetrical UreasMan-kit Leung, Jun-Liang Lai, King-Hang Lau, Hsiao-hua Yu, and Hsiang-Ju HsiaoView Author Information Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China Cite this: J. Org. Chem. 1996, 61, 12, 4175–4179Publication Date (Web):June 14, 1996Publication History Received28 December 1995Published online14 June 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo9522825https://doi.org/10.1021/jo9522825brief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views2746Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Amines,Chemical reactions,Reagents,Urea Get e-Alerts
Non-dipping pattern of nocturnal blood pressure in obstructive sleep apnea syndrome: Possible role of oxidative stress and endothelin-1 precursor (2013)

BackgroundThere is growing evidence suggesting that obstructive sleep apnea OSA is linked to the occurrence of cardiovascular disorders. Lack of normal nocturnal dipping of blood pressure has also been considered a risk factor for the occurrence of cardiovascular disorders. Non-dipping has been described in patients with OSA and is attributed to autonomic dysfunction. However, the search for a causal link between OSA and cardiovascular disease is still underway.ObjectiveTo evaluate the occurrence of non-dipping pattern of nocturnal blood pressure, and the possible role of oxidative stress and ET-1 precursor in patients with OSA.Subjects and methodsThirty eight patients with OSA and fourteen normal control subjects were enrolled in this study and were subjected to history taking, clinical examination, early morning blood samplings for the measurement of serum malondialdehyde (MDA) and endothelin 1 precursor (ET-1 precursor). All patients with OSA were subjected to full polysomnographic study and monitoring of nocturnal blood pressure changes.ResultsNocturnal blood pressure measurement of all patients revealed that thirty six patients (94.7%) were non-dippers, 15 patients (39.5%) suffered from ischemic heart disease. Serum endothelin-1 precursor and serum malondialdehyde levels were significantly higher in patients with OSA than in the control group. The systolic blood pressure measured before sleep was also significantly higher in patients than in the control group. The Epworth sleepiness scale and the clinical apnea score were significantly higher in patients than in the control group.ConclusionsThe high incidence of non-dipping pattern of nocturnal blood pressure in both normotensive and hypertensive patients with OSA may be considered a warning sign for the occurrence of cardiovascular complications in these patients. Both increased oxidative stress and ET-1 precursor may be among the causative factors responsible for the high prevalence of the non-dipping pattern through increasing sympathetic nervous system activity.