gebhart/patrepeval huggingface dataset:
Be diffusion in InGaAs/InP heterojunction bipolar transistors (2000)

Classic signatures of Be diffusion were observed in InAlAs/InGaAs HBT's after elevated temperature bias stress, i.e., a positive shift in the Gummel plot, higher collector ideality, and higher offset voltage. An activation energy of 1.57 eV was calculated. Lifetimes of 3.3/spl times/106 h and 37000 h were extrapolated for low and high power operation, respectively. In contrast, an InP/InGaAs HBT with a C doped base showed no signatures of C diffusion. The results show that Be diffusion is manageable at lower power. They also support the idea that C is more stable than Be in this material system.
Specific Elimination of CD133+ Tumor Cells with Targeted Oncolytic Measles Virus (2013)

Tumor-initiating cells (TIC) are critical yet evasive targets for the development of more effective antitumoral strategies. The cell surface marker CD133 is frequently used to identify TICs of various tumor entities, including hepatocellular cancer and glioblastoma. Here, we describe oncolytic measles viruses (MV) retargeted to CD133. The viruses, termed MV-141.7 and MV-AC133, infected and selectively lysed CD133(+) tumor cells. Both viruses exerted strong antitumoral effects on human hepatocellular carcinoma growing subcutaneously or multifocally in the peritoneal cavity of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Notably, the CD133-targeted viruses were more effective in prolonging survival than the parental MV-NSe, which is currently assessed as oncolytic agent in clinical trials. Interestingly, target receptor overexpression or increased spreading kinetics through tumor cells were excluded as being causative for the enhanced oncolytic activity of CD133-targeted viruses. MV-141.7 was also effective in mouse models of orthotopic glioma tumor spheres and primary colon cancer. Our results indicate that CD133-targeted measles viruses selectively eliminate CD133(+) cells from tumor tissue, offering a key tool for research in tumor biology and cancer therapy.
Nichtmarxistische Soziologie zum Zusammenhang von wissenschaftlich- technischer Revolution und gesellschaftlicher Entwicklung (1988)

Article Nichtmarxistische Soziologie zum Zusammenhang von wissenschaftlich- technischer Revolution und gesellschaftlicher Entwicklung was published on July 1, 1988 in the journal Deutsche Zeitschrift für Philosophie (volume 36, issue 7).
Global analysis of the glycoproteome in <i>Saccharomyces cerevisiae</i> reveals new roles for protein glycosylation in eukaryotes (2009)

To further understand the roles of protein glycosylation in eukaryotes, we globally identified glycan-containing proteins in yeast. A fluorescent lectin binding assay was developed and used to screen protein microarrays containing over 5000 proteins purified from yeast. A total of 534 yeast proteins were identified that bound either Concanavalin A (ConA) or Wheat-Germ Agglutinin (WGA); 406 of them were novel. Among the novel glycoproteins, 45 were validated by mobility shift upon treatment with EndoH and PNGase F, thereby extending the number of validated yeast glycoproteins to 350. In addition to many components of the secretory pathway, we identified other types of proteins, such as transcription factors and mitochondrial proteins. To further explore the role of glycosylation in mitochondrial function, the localization of four mitochondrial proteins was examined in the presence and absence of tunicamycin, an inhibitor of N-linked protein glycosylation. For two proteins, localization to the mitochondria is diminished upon tunicamycin treatment, indicating that protein glycosylation is important for protein function. Overall, our studies greatly extend our understanding of protein glycosylation in eukaryotes through the cataloguing of glycoproteins, and describe a novel role for protein glycosylation in mitochondrial protein function and localization.
Sirtuins, a promising target in slowing down the ageing process (2017)

Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even prevent some age-related pathologies. There are some defined interventions, which give promising results in animal models or even in human studies, resulting in lifespan elongation or healthspan improvement. One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals). In humans the family consists of seven members (SIRT1-7) that possess either mono-ADP ribosyltransferase or deacetylase activity. It is believed that sirtuins play key role during cell response to a variety of stresses, such as oxidative or genotoxic stress and are crucial for cell metabolism. Although some data put in question direct involvement of sirtuins in extending human lifespan, it was documented that proper lifestyle including physical activity and diet can influence healthspan via increasing the level of sirtuins. The search for an activator of sirtuins is one of the most extensive and robust topic of research. Some hopes are put on natural compounds, including curcumin. In this review we summarize the involvement and usefulness of sirtuins in anti-ageing interventions and discuss the potential role of curcumin in sirtuins regulation.
USB Complete: Everything You Need to Develop Custom USB Peripherals (1999)

From the Publisher:
Every Windows 98 and Windows 2000 computer contains Universal Serial Bus ports for connecting to a variety of peripherals. This guide takes the pain out of designing for this popular interface with specific, detailed examples that show how to develop USB devices and the applications that communicate with them. How the USB communicates with the PC, deciding if a project should use a USB interface, choosing a USB controller chip for peripheral design, and determining code which USB peripherals need to communicate with Windows applications are covered in detail. Reflecting the changes in the newly released USB 2.0 standard, this book also includes a complete project that shows how to develop a custom USB peripheral from start to finish.
Author Biography: Jan Axelson is the author of Serial Port Complete, Parallel Port Complete, The Micro Controller Idea Book, and Making Printed Circuit Boards. She lives in Madison, Wisconsin.
Managing Computer Networks: A Case-Based Reasoning Approach (1995)

From the Publisher:
This is the first book to discuss the applications of CBR to network management. It takes a close look at the components of the CBR paradigm, and also examines the contribution of CBR as one component of a larger system for managing computer networks.
THE PASSIVE TRANSFER OF ACQUIRED RESISTANCE TO LISTERIA MONOCYTOGENES (1964)

Five methods have been used in an effort to reveal an antibody that could account for the features of acquired resistance to Listeria monocytogenes: (a) a comparison of the growth rates of Listeria in the spleens of mice infused repeatedly with normal or immune mouse serum; (b) measurement of peritoneal clearance of Listeria in the presence of normal or immune mouse serum; (c) the survival rate of Listeria in monolayers of mouse macrophages infected in the presence of normal or immune mouse serum; (d) the effect of injecting urea extracts of spleens and peritoneal macrophages of normal or immune mice on the survival and growth of Listeria in recipient animals; (e) a comparison of survival rates in lethally infected mice following the passive transfer of cells and serum from normal or immune donors. The only evidence of passive protection was obtained when intact living cells from immune donors were used for transfer under conditions which permitted them to interact with the parasite population.
Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study (1999)

We found no overall difference between glyceryl trinitrate and ritodrine in the acute tocolysis of preterm labor but a suggested advantage of glyceryl trinitrate over ritodrine in reducing preterm delivery rate. The maternal side effect profile and treatment discontinuation rates were fewer for glyceryl trinitrate, suggesting it was a safer alternative to ritodrine.
A relaxation algorithm for segmentation of the endocardial surface from cine CT (2003)

A relaxation algorithm has been developed for automated segmentation of the endocardial surface from contrast cine-CT (computer tomography) images. The image is contoured at an initial density threshold, and a one-dimensional edge operator is applied orthogonally to each point of the contour. Output from the operator is used to generate a histogram, the mode of which identifies a new threshold. The image is contoured again at the new threshold and the process is repeated. Iteration continues with successive threshold estimates converging to a stable value in the region of the endocardial surface. Computer-determined thresholds compare favorably with manual segmentation while reducing processing time and increasing reproducibility.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Viral DNA synthesized in vitro by avian retrovirus particles permeabilized with melittin. II. Evidence for a strand displacement mechanism in plus-strand synthesis (1981)

Analyses of the native DNA product of mellitin-activated avian retrovirus reverse transcription have revealed a unique structure. The vast majority of the molecules were linear, either 7.7 (genome) or 8.0 (extended genome) kilobases in length, and contained single-stranded DNA branches distributed throughout. These conclusions are based on electrophoretic properties of intact and restriction endonuclease-treated molecules before and after treatment with single-strand-specific nuclease S1. Preliminary data from linear viral DNA extracted from infected cells suggest that these molecules have a similar structure. The findings summarized in this report and those in the preceding paper indicated that the single-stranded branches are of positive polarity and are generated by a strand displacement mechanism. The existence of these branches suggests a role for strand displacement in replication and recombination.
Economy oriented model predictive load frequency control (2003)

In this paper, model predictive control (MPC) scheme is used to develop the proposed load frequency controller. In each sampling interval, an optimization procedure is performed to calculate optimal control actions. In addition, it has the ability to incorporate economic objectives as part of control requirements. Here, it applies the wedge control philosophy to minimize unit maneuvering and reversals, which affect load frequency control (LFC) costs. The proposed methodology is tested with a three-area power system. Simulation results show that the proposed LFC successfully complies with NERC's control performance standards, and also achieves the economic objective.
Out of vehicle channel sounding in 5.8 GHz band (2015)

The article presents out-of-vehicle channel measurement results in the 5.8 GHz frequency band which is used in the IEEE 802.11p standard. Experiments for two different distances and three different angles around the parked car are carried out. It is found that a two-term exponential decay model can satisfactorily describe the mean measured power delay profiles. For each measurement, this large scale variation is used to calculate the corresponding channel impulse response and to construct a Rician tap-delay multipath channel model. Bit error rate (BER) performance for each measured location is then evaluated through MATLAB based simulation. The simulation results indicate that the error performances do not vary much and it is possible to determine an average BER curve for the whole set of data.
Navigating with Graph Representations for Fast and Scalable Decoding of Neural Language Models (2018)

Neural language models (NLMs) have recently gained a renewed interest by achieving state-of-the-art performance across many natural language processing (NLP) tasks. However, NLMs are very computationally demanding largely due to the computational cost of the softmax layer over a large vocabulary. We observe that, in decoding of many NLP tasks, only the probabilities of the top-K hypotheses need to be calculated preciously and K is often much smaller than the vocabulary size. This paper proposes a novel softmax layer approximation algorithm, called Fast Graph Decoder (FGD), which quickly identifies, for a given context, a set of K words that are most likely to occur according to a NLM. We demonstrate that FGD reduces the decoding time by an order of magnitude while attaining close to the full softmax baseline accuracy on neural machine translation and language modeling tasks. We also prove the theoretical guarantee on the softmax approximation quality.
Data entry curricula guidelines (1979)

article Free Access Share on Data entry curricula guidelines: a working paper of the Community and Junior College Subcommittee (CAJC) of the Curriculum Committee on Computer Education (C3E) Authors: Iva Helen Lee Association for Computing Machinery (ACM), New York, NY Association for Computing Machinery (ACM), New York, NYView Profile , Donna Hutcheson Association for Computing Machinery (ACM), New York, NY Association for Computing Machinery (ACM), New York, NYView Profile , Joyce Currie Little Association for Computing Machinery (ACM), New York, NY Association for Computing Machinery (ACM), New York, NYView Profile Authors Info & Claims ACM SIGCSE BulletinVolume 11Issue 3September 1979 pp 15–39https://doi.org/10.1145/988933.988936Online:01 September 1979Publication History 1citation98DownloadsMetricsTotal Citations1Total Downloads98Last 12 Months13Last 6 weeks8 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Virus Diseases of Sawflies (1955)

Although a virus disease of the larch sawfly, Pristiphora erichsonii (Htg.), has not been discovered, polyhedrosis viruses of several other Tenthredinids are known. They have been used to control infestations of two introduced species: the European spruce sawfly, Diprion hercyniae (Htg.), (Bird, 1954) and the European pine sawfly, Neodiprion sertifer (Geoffr.), (Bird, 1950, 1952, 1953; Dowden, 1953). Unfortunately, the viruses of these, as well as the viruses of several other species tested, are not pathogenic to the larch sawfly. Some viruses, however, appear to he pathogenic to more than one species. J. M. Burk of this laboratory found, for example, that a polyhedrosis virus affecting the native jackpine sawfly, Neudiprion americanus banksianae Roh., is pathogenic to N. sertifer, N. nanulus Schedl, and D. hercyniae .
Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy (2011)

The clinical implications of enlarged early cortical components of somatosensory evoked potentials in benign adult familial myoclonus epilepsy remain unknown. Somatosensory evoked potentials following electrical stimulation of the median nerve at the wrist were studied in 16 patients with a clinical diagnosis of benign adult familial myoclonus epilepsy (7 men and 9 women; mean age, 51 ± 18 years) and 19 age-matched apparently healthy control subjects (11 men and 8 women; mean age, 49 ± 18 years). Giant somatosensory evoked potentials were observed in 13 of the 16 patients. P25 and N35 amplitudes in the patient group were 11.4 ± 6.1 and 19.2 ± 11.5 μV, respectively, and both were significantly larger compared with those in control subjects (P = 0.008 for P25 and P < 0.0001 for N35). There was a significant positive relationship between age at somatosensory evoked potential examination and N20, P25, and N35 amplitudes, both in the patient and in the control groups (P < 0.05). The linear regression gradient of the N35 amplitude with respect to age was significantly larger in the patient group than in the control group (P = 0.04). Furthermore, regression analysis showed a significant positive relationship between the myoclonus rating scale and age at time of somatosensory evoked potential examination (R = 0.645, P = 0.007). Somatosensory evoked potential amplitude increased with age in patients with benign adult familial myoclonus epilepsy to a greater extent than in the control subjects, which suggests a progressive increase in cortical excitability based on progressive pathophysiology in benign adult familial myoclonus epilepsy.
The Chemiluminescence of Tetrakis(dimethylamino)ethylene<sup>1</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemiluminescence of Tetrakis(dimethylamino)ethylene1H. E. Winberg, J. R. Downing, and D. D. CoffmanCite this: J. Am. Chem. Soc. 1965, 87, 9, 2054–2055Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/ja01087a039https://doi.org/10.1021/ja01087a039research-articleACS PublicationsRequest reuse permissionsArticle Views267Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tungsten nanowires and their field electron emission properties (2002)

We report the fabrication of tungsten nanowires, by simple thermal treatment of W films, that behave as self-catalytic layers and their excellent electron field emission properties as well. The obtained nanowires have a diameter ranging from 10 to 50 nm, showing perfect straightness and neat appearance. Typical turn-on field for the electron emission is about 5 V/μm, and the field enhancement factor β becomes 38 256, which is very close to that of the high efficient single-wall carbon nanotube emitters. The most exciting result is the possibility of easy fabrication of perfectly straight nanowires as promising building blocks for terabit-level interconnection and nanomachine components without the intentional use of any heterogeneous catalysts.
Production of Acid Heteropolysaccharides from n-Paraffine (1969)

Production of Acid Heteropolysaccharides from n-Paraffine Get access Tsuneo Kanamaru, Tsuneo Kanamaru Microbiological Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd., Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar Saburō Yamatodani Saburō Yamatodani Microbiological Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd., Osaka, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 33, Issue 10, 1 October 1969, Pages 1521–1522, https://doi.org/10.1080/00021369.1969.10859498 Published: 01 October 1969 Article history Received: 24 July 1969 Published: 01 October 1969
Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1) (2013)

Human mesenchymal stem/precursor cells (MSC) are similar to some other stem/progenitor cells in that they compact into spheres when cultured in hanging drops or on nonadherent surfaces. Assembly of MSC into spheres alters many of their properties, including enhanced secretion of factors that mediate inflammatory and immune responses. Here we demonstrated that MSC spontaneously aggregated into sphere-like structures after injection into a subcutaneous air pouch or the peritoneum of mice. The structures were similar to MSC spheres formed in cultures demonstrated by the increased expression of genes for inflammation-modulating factors TSG6, STC1, and COX2, a key enzyme in production of PGE2. To identify the signaling pathways involved, hanging drop cultures were used to follow the time-dependent changes in the cells as they compacted into spheres. Among the genes upregulated were genes for the stress-activated signaling pathway for IL1α/β, and the contact-dependent signaling pathway for Notch. An inhibitor of caspases reduced the upregulation of IL1A/B expression, and inhibitors of IL1 signaling decreased production of PGE2, TSG6, and STC1. Also, inhibition of IL1A/B expression and secretion of PGE2 negated the anti-inflammatory effects of MSC spheres on stimulated macrophages. Experiments with γ-secretase inhibitors suggested that Notch signaling was also required for production of PGE2 but not TSG6 or STC1. The results indicated that assembly of MSC into spheres triggers caspase-dependent IL1 signaling and the secretion of modulators of inflammation and immunity. Similar aggregation in vivo may account for some of the effects observed with administration of the cells in animal models.
Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome (2019)

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury. Recent work supports the role of γ-aminobutyric-acid (GABA), the primary inhibitory neurotransmitter in the brain, in mediating symptoms of FXS. Deficits in GABA machinery have been observed in a mouse model of FXS, including a loss of tonic inhibition in the amygdala, which is mediated by extrasynaptic GABA<sub>A</sub> receptors. Humans with FXS also show reduced GABA<sub>A</sub> receptor availability. Here, we sought to evaluate the potential of gaboxadol (also called OV101 and THIP), a selective and potent agonist for delta-subunit-containing extrasynaptic GABA<sub>A</sub> receptors (dSEGA), as a therapeutic agent for FXS by assessing its ability to normalize aberrant behaviors in a relatively uncharacterized mouse model of FXS (<i>Fmr1</i> KO2 mice). Four behavioral domains (hyperactivity, anxiety, aggression, and repetitive behaviors) were probed using a battery of behavioral assays. The results showed that <i>Fmr1</i> KO2 mice were hyperactive, had abnormal anxiety-like behavior, were more irritable and aggressive, and had an increased frequency of repetitive behaviors compared to wild-type (WT) littermates, which are all behavioral deficits reminiscent of individuals with FXS. Treatment with gaboxadol normalized all of the aberrant behaviors observed in <i>Fmr1</i> KO2 mice back to WT levels, providing evidence of its potential benefit for treating FXS. We show that the potentiation of extrasynaptic GABA receptors alone, by gaboxadol, is sufficient to normalize numerous behavioral deficits in the FXS model using endpoints that are directly translatable to the clinical presentation of FXS. Taken together, these data support the future evaluation of gaboxadol in individuals with FXS, particularly with regard to symptoms of hyperactivity, anxiety, irritability, aggression, and repetitive behaviors.