gebhart/patrepeval huggingface dataset:
Phosphorylation of eukaryotic initiation factor EIF-4E (1987)

Eukaryotic protein synthesis initiation factor eIF-4E is a 25-kDa protein which binds to the cap structure of mRNA and is involved in the entry of mRNA into the initiation of protein synthesis. EIF-4E is isolated as a mixture of phosphorylated and nonphosphorylated forms. The site of phosphorylation was determined to be serine-53 of the eIF-4E sequence. The amino acid sequence surrounding the phosphorylated serine is 40-QNRWALWFFKNDKSKTWQANLRL-62. Tryptic digestion of eIF-4E, labeled with /sup 32/P in intact rabbit reticulocytes, yielded one labeled peptide whose amino acid composition was consistent with the structure SK. After treatment of the protein with citraconic anhydride to block lysyl residues, tryptic digestion yielded a labeled peptide whose composition was consistent with the structure WALWFFKNDKSKTWQANLR. A protein kinase was purified from rabbit reticulocyte lysate which specifically phosphorylated eIF-4E and not other initiation factors. Peptide analysis of the in vitro-phosphorylated protein revealed that a single site was phosphorylated and that it was the same as the in vivo-phosphorylated site. Comparison of eIF-4E and eIF-4F as substrates for the kinase revealed that the K/sub s/ was 15-fold lower for eIF-4F, indicating that the latter is the preferred substrate.
Messenger Ribonucleic Acid from Tumors Associated with Humoral Hypercalcemia of Malignancy Directs the Synthesis of a Secretory Parathyroid Hormone-Like Peptide* (1985)

Previous studies have provided evidence that tumors associated with humoral hypercalcemia of malignancy produce a factor that shares certain biological properties with, but is not, native PTH. In the present study, media from Xenopus oocytes microinjected with polyadenylated RNA prepared from three human or animal tumors associated with humoral hypercalcemia of malignancy are shown to have activity in the cytochemical bioassay for PTH. This activity parallels that of the PTH standard in the assay and is completely inhibited by the PTH analog [Nle8,Nle18,Tyr34]bovine PTH-(3-34)NH2. Media from oocytes injected with mRNA from control tumors contain no such activity. The mRNA encoding this activity in one of the animal tumors has been enriched approximately 10-fold by preparative polyacrylamide gel electrophoresis. These results demonstrate that tumors associated with humoral hypercalcemia of malignancy have the capacity for directing the synthesis of a secretory protein that fulfills certain criteria for being the humoral mediator in question. These techniques may provide the basis for molecular cloning of this factor.
Pyrimidines. Part III. Synthesis of some 5-alkylthiopyrimidines (1970)

The reaction of n-alkanesulphenyl halides with a number of pyrimidines, in which the pyrimidine 5-position is unsubstituted but which carry at least two strongly electron-releasing substituents gives 5-alkylthiopyrimidines in good yield.
FULL-SCALE TEST OF PRESTRESSED DOUBLE-TEE BEAM (2003)

The Bridge Street Bridge in Southfield, Michigan, is the most recent carbon fiber-reinforced polymer (CFRP) prestressed concrete bridge in the United States, and the first to use CFRP tendons, carbon fiber composite cable (CFCC) strands and CFRP sheets. Due to the lack of existing design standards for FRP prestressed concrete bridges, the design and construction approach was validated by testing a full-scale double-tee (DT) beam to failure. This study describes the experimental investigation of the DT test beam, including critical major structural parameters such as concrete strains, deflections, forces in the post-tensioning strands at the service load, cracking load, ultimate load, and the type and pattern of failure experience at the ultimate load. Results showed that the combined internal and external prestressing induced the desired compressive strains in the cross section, which balanced the tensile strains induced by the applied load to prevent service load cracking in the beam. The ultimate flexural capacity and the cracking of the DT beam were determined to be about 3.4 and 1.2 times the service moment, respectively. In addition, the tested flexural strength was about 1.6 times that of the calculated capacity. The beam webs experienced significant cracking before the failure load. Crushing of the concrete topping, followed by the rupture of the internal prestressing tendons, initiated the failure of the DT beam. However, none of the external unbonded CFCC post-tensioning strands ruptured. These results provided the design team with enough information to proceed with the development of the design approach and construction documents for the bridge.
Thin-Body N-Face GaN Transistor Fabricated by Direct Wafer Bonding (2011)

This letter presents a method to fabricate thin-body N-face GaN-on-insulator-on-Si (100) wafers. These new wafers are promising to increase the carrier confinement and reduce the contact resistance in AlGaN/GaN high electron mobility transistors (HEMTs). In the reported technology, a Ga-face AlGaN/GaN epilayer grown on Si (111) is transferred to a Si (100) wafer by direct wafer bonding and thinned down by selective dry etch to the device active layers. A GaN channel thickness as thin as 20 nm is obtained with the use of AlGaN etch-stop layers. Excellent transport characteristics are obtained in the fabricated thin-body N-face AlGaN/GaN structures, with a sheet resistance of 430 Ω/sq, an electron mobility of 1700 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V · s, and a 2-D electron gas concentration of 9 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . HEMTs fabricated on these N-face thin-body epilayers shows excellent current-voltage characteristics and great potential for high-frequency applications.
WebMon: A performance profiler for web transactions (2003)

We describe WebMon, a tool for correlated, transaction-oriented performance monitoring of web services. Data collected with WebMon can be analyzed from a variety of perspectives: business, client, transaction, or systems. Maintainers of web services can use such analysis to better understand and manage the performance of their services. Moreover WebMon's data will enable the construction of more accurate performance prediction models for web services. Current web logging techniques create a log file per server making it difficult to correlate data from log files with respect to a given transaction. Additionally, data about the quality of service perceived by the client is missing entirely. WebMon overcomes these limitations by providing heterogenous instrumentation sensors and HTTP cookie-based correlators. In this paper, we present the design and implementation of of WebMon and our experience in applying WebMon to an HP Library web service.
An Analysis of Home IoT Network Traffic and Behaviour (2018)

Internet-connected devices are increasingly present in our homes, and privacy breaches, data thefts, and security threats are becoming commonplace. In order to avoid these, we must first understand the behaviour of these devices. In this work, we analyse network traces from a testbed of common IoT devices, and describe general methods for fingerprinting their behavior. We then use the information and insights derived from this data to assess where privacy and security risks manifest themselves, as well as how device behavior affects bandwidth. We demonstrate simple measures that circumvent attempts at securing devices and protecting privacy.
Finding Pitch Markers using First Order Gaussian Differentiator (2005)

In this paper we propose a method for detecting pitch markers in the speech signal using first order Gaussian differentiator. The speech signal is processed by the linear prediction (LP) analysis to extract the LP residual signal. The peaks around the glottal closure instants in the LP residual are used as pitch markers in this study. The LP residual is convolved with the first order Gaussian differentiator of length 20 msec. Due to the anti-symmetric nature of the first order Gaussian differentiator, there are zero-crossings around the significant peaks in the LP residual. Some of the detected zero-crossings may also correspond to peaks due to excitations like glottal openings in voiced speech and bursts and friction in unvoiced speech. These unwanted zero-crossings are eliminated using energy of the LP residual. The remaining peaks are hypothesized as pitch markers in the speech signal. The proposed method works for both male and female speakers, but for clean speech case only
Impact of a restricted natural language interface on ease of learning and productivity (1989)

People process natural language in real time and with very limited short-term memories. This article describes a computational architecture for syntactic performance that also requires fixed finite resources.
Anodic Control of Corrosion in a Sulfonation Plant (1960)

Using the newly developed automatic potential controller, anodic protection can be used to prevent a severe corrosion problem in the manufacture of petroleum sulfonates. Corrosion was a major problem in a mild steel oleum storage tank and in a 304 stainless steel sulfonic acid neutralization vessel. Laboratory studies of anodic polarization curves showed that anodic protection was theoretically possible in both these systems. A potential controller, suitable platinum cathode and reference electrode were designed and successfully installed on each vessel. A solid reference electrode was necessary since the usual calomel or copper sulfate reference electrodes were not suited to the system of high temperature and extreme agitation. The effectiveness of anodic protection was measured in terms of (1) reduction in iron concentration throughout the process; (2) improved quality of product due to absence of colored iron salts; (3) increased productivity of plant due to more rapid product hydrocarbon separation due to the absence of iron soaps. This equipment has continuously and automatically controlled corrosion in a sulfonation plant for one year. 2.4.2
Current risks of viral hepatitis from blood transfusions (1998)

The incidence of transfusion-associated hepatitis in the United States has fallen dramatically since the late 1960s. Where once the risks were so great that as many as one in three transfused patients contracted hepatitis, now they are infinitesimal. Many factors share responsibility for this accomplishment; however, two stand above the rest: (i) improved donor selection and screening criteria, especially elimination of paid blood donations; and (ii) major advances in testing for viral hepatitis carriers. Currently, four tests are used for the prevention of transfusion-associated hepatitis: (i) hepatitis B surface antigen; (ii) hepatitis C virus antibody; (iii) hepatitis B core antibody; and (iv) alanine aminotransferase. The first two tests are largely responsible for the current low risks of transfusion-associated hepatitis due to hepatitis B virus and hepatitis C virus of 1 in 63,000 and 1 in 125,000, per unit, respectively. To further reduce the risks of transfusion-associated hepatitis will require the enhanced sensitivity provided by nucleic acid amplification techniques (e.g. polymerase chain reaction). Currently, however, no such tests are licensed and practical, automated, or inexpensive enough for individual blood donor screening. We have made such great strides in the prevention of transfusion-transmitted hepatitis that background rates of viral hepatitis now greatly exceed the risk of transmission via transfusion. For this reason, while it may still be reasonable to consider a transfusion as a possible cause for hepatitis, it is imperative that many other possibilities (e.g., iatrogenic and other risk factors) be ruled out.
A non-antibiotic antimicrobial mixture (C31G): evaluation of the antimicrobial efficiency of C31G on vaginal cultures. (1992)

Minimum inhibitory concentrations and the effective period for cidal concentrations of an amphoteric surfactant mixture (C31G) were determined on 13 microorganisms (common bacteria, strains ATCC, and fungi) by microtiter dilution procedure. Also the antimicrobial efficiency of this composition (C31G) was evaluated on 105 culture samples which were obtained from (Turkish) patients having vaginal infections. E. coli was found to be the most frequently observed microorganism (45.45%) in these samples and C31G was determined to be active on microorganisms obtained from vagina at low concentrations in a short time.
Comparison of <i>Corynebacterium parvum</i> and <i>Bordetella pertussis</i> With Freund's Complete Adjuvant as Immunopotentiators for β‐Human Chorionic Gonadotropin Linked to an Atoxic Fragment of Tetanus Toxin (1989)

Corynebacterium parvum and Bordetella pertussis were compared with Freund's complete adjuvant (FCA) for their abilities to potentiate the immune response to haptenic beta-human chorionic gonadotropin covalently coupled to an atoxic 54,000-molecular-weight fragment of tetanus toxin (beta-hCG-TTII). The ability of each adjuvant to enhance production of antibodies to hCG in rabbits was measured by 125I-hCG radioimmunoassay. At sera dilutions of 1:10,000, analysis of variance for the 8-week postimmunization course showed that the mean 125I-hCG binding capacities of the C. parvum group was significantly greater overall than the B. pertussis group (P = .0002) and that the FCA-treated group had the greatest binding capacity overall (P less than .018). The mean binding capacities at 1:40,000 dilution again showed the FCA-treated group to have significantly higher anti-hCG titers overall (P less than .0015), with C. parvum potentiating a greater overall antibody response than B. pertussis (P = .001). These results indicate that FCA is the most efficacious of the three tested adjuvants in potentiating antibody production to the hapten component of beta-hCG-TTII. C. parvum was also effective at promoting an anti-beta-hCG response, although not to the same degree as FCA. B. pertussis had only minimal potentiating effect compared to FCA or C. parvum.
Cell-ID Location Technique, Limits and Benefits: An Experimental Study (2005)

The mobile phone market lacks a satisfactory location technique that is accurate, but also economical and easy to deploy. Current technology provides high accuracy, but requires substantial technological and financial investment. In this paper, we present the results of experiments intended to asses the accuracy of inexpensive Cell-ID location technique and its suitability for the provisioning of location based services. We first evaluate the accuracy of Cell-ID in urban, suburban and highway scenarios (both in U.S. and Italy), we then introduce the concepts of discovery-accuracy and discovery-noise to estimate the impact of positioning accuracy on the quality of resource discovery services. Experiments show that the accuracy of Cell-ID is not satisfactory as a general solution. In contrast we show how Cell-ID can be effectively exploited to implement more effective and efficient voice location-based services.
Zinc oxide thin-film random lasers on silicon substrate (2004)

Room-temperature ultraviolet lasing is demonstrated in mirrorless zinc oxide thin-film waveguides on (100) silicon substrate. Laser cavities, due to closed-loop optical scattering from the lateral facets of the irregular zinc oxide grains, are generated through the post-growth annealing of high-crystal-quality zinc oxide thin films obtained from the filtered cathodic vacuum arc technique. It is found that the lasing wavelength and linewidth of the zinc oxide random lasers under 355 nm optical excitation are around 390 nm and less than 0.4 nm, respectively. In addition, the lasing threshold characteristics are in good agreement with the random laser theory.
Spoken Dialogue Technology (2002)

Spoken dialogue systems allow users to interact with computer-based applications such as databases and expert systems by using natural spoken language. The origins of spoken dialogue systems can be traced back to Artificial Intelligence research in the 1950s concerned with developing conversational interfaces. However, it is only within the last decade or so, with major advances in speech technology, that large-scale working systems have been developed and, in some cases, introduced into commercial environments. As a result many major telecommunications and software companies have become aware of the potential for spoken dialogue technology to provide solutions in newly developing areas such as computer-telephony integration. Voice portals, which provide a speech-based interface between a telephone user and Web-based services, are the most recent application of spoken dialogue technology. This article describes the main components of the technology---speech recognition, language understanding, dialogue management, communication with an external source such as a database, language generation, speech synthesis---and shows how these component technologies can be integrated into a spoken dialogue system. The article describes in detail the methods that have been adopted in some well-known dialogue systems, explores different system architectures, considers issues of specification, design, and evaluation, reviews some currently available dialogue development toolkits, and outlines prospects for future development.
Cyclic Voltammetric Analysis of Organophosphorous Esters (1986)

Mise au point sur l'activite electrochimique d'une serie d'esters organophosphoriques. Revue des resultats obtenus dans du DMF et de l'acetonitrile. Discussion detaillee dans le cas des composes presentant une activite d'oxydation
Fundamentals of Transportation and Traffic Operations (1997)

Introductory chapters on &#x0201C;tools&#x0201D; cover topics such as graphical methods, optimization, probability, stochastic processes, statistics and simulation; these are complemented by application chapters on traffic dynamics, control, observation, and scheduled modes, where the fundamental ideas are presented in depth.
Synthesis and in vitro cytotoxic activity of aza- and diazaanthraquinone derivatives. (1994)

Some 1,4-dihydro aza- and 1,4-dihydro diazaanthraquinone derivatives have been synthesized and submitted to in vitro cytotoxicity tests towards L 1210, MDA-MB 231 and PC3 cell lines. Some of the new substances showed significant activity.
A General Approach to Product Design Optimization Via Conjoint Analysis (1981)

This paper describes some of the features of POSSE (Product Optimization and Selected Segment Evaluation), a general procedure for optimizing product/service designs in marketing research. The approach uses input data based on conjoint analysis methods. The output of consumer choice simulators is modeled by means of response surface techniques and optimized by different sets of procedures, depending upon the nature of the objective function.
Coronary veins: an alternate route to ischemic myocardium. (1992)

Acute myocardial ischemia is the primary cause of concern during myocardial infarction and unstable angina, and the cornerstone of modern therapy is rapid establishment of antegrade blood flow. The ultimate success of reperfusion depends on the duration and severity of ischemia before revascularization. Even brief ischemia occurring during angioplasty may cause reversible myocardial dysfunction. Several interventions are available to minimize the negative effects of acute myocardial ischemia. Synchronized coronary venous retroperfusion is a myocardial support technique in which autologous arterial blood is shunted from the femoral artery into the ischemic myocardium via the coronary sinus. Retroperfusion has been studied clinically during angioplasty and has been shown to ameliorate and delay the onset of ischemia. It has also been beneficial during abrupt closure of the coronary artery after angioplasty as a bridge to definitive therapy. Preliminary reports have indicated the efficacy of retroperfusion in medically refractory unstable angina. Because of its retrograde approach, this technique may serve as an alternate route to an otherwise inaccessible, ischemic myocardium for delivery of blood and other cardioprotective agents.
Introduction to object-oriented databases (1992)

Introduction to Object-Oriented Databases provides the first unified and coherent presentation of the essential concepts and techniques of object-oriented databases. It consolidates the results of research and development in the semantics and implementation of a full spectrum of database facilities for object-oriented systems, including data model, query, authorization, schema evolution, storage structures, query optimization, transaction management, versions, composite objects, and integration of a programming language and a database system.The book draws on the author's Orion project at MCC, currently the most advanced object-oriented database system, and places this work in a larger context by using relational database systems and other object-oriented systems for comparison.Won Kim is Director of the Object-Oriented and Distributed Systems Laboratory at Microelectronics and Computer Technology Corporation (MCC) in Austin, Texas.Contents: Introduction. Data Model. Basic Interface. Relationships with Non-Object-Oriented Databases. Schema Modification. Model of Queries. Query Language. Authorization. Storage Structures. Query Processing. Transaction Management. Semantic Extensions. Integrating Object-Oriented Programming and Databases. Architecture. Survey of Object-Oriented Database Systems. Directions for Future Research and Development.
Filters for ν_2 band of CO_2: monitoring and control of layer deposition (1976)

Two types of multilayer interference filter are required for temperature sounding the earth's atmosphere. In relation to the 668-cm(-1) nu(2) band of CO(2) these are narrowband (4 cm(-1) wide for the Q branch, 10 cm(-1) for the R branch) or isolation (~60 cm(-1) wide for the complete center of the band). Difficulty in manufacturing the filters for NIMBUS-SCR and -PMR spaceflight has indicated a need for improvement in the monitoring and control of the deposition of layers, and the paper describes a realization of this. The consequent effect on filter performance (utilizing a particular combination of layer materials) is described.
ULTRAMICROPOROUS MEMBRANES FOR HYDROGEN SEPARATION (2002)

Fuel cell systems offer excellent efficiencies when compared to internal combustion engines, which result in reduced fuel consumption and greenhouse gas emissions. One of the areas requiring research for the success of fuel cell technology is the H2 fuel purification to reduce CO, which is a poison to fuel cells. Molecular sieve silica (MSS) membranes have a potential application in this area. In this work showed activated transport, a characteristic of ultramicroporous (dp
Neural-network control of mobile manipulators (2001)

In this paper, a neural network (NN)-based methodology is developed for the motion control of mobile manipulators subject to kinematic constraints. The dynamics of the mobile manipulator is assumed to be completely unknown, and is identified online by the NN estimators. No preliminary learning stage of NN weights is required. The controller is capable of disturbance-rejection in the presence of unmodeled bounded disturbances. The tracking stability of the closed-loop system, the convergence of the NN weight-updating process and boundedness of NN weight estimation errors are all guaranteed. Experimental tests on a 4-DOF manipulator arm illustrate that the proposed controller significantly improves the performance in comparison with conventional robust control.