gebhart/patrepeval huggingface dataset:
Elevated Amniotic Fluid Nucleosome Levels in Women With Intra-amniotic Infection (1999)

In Brief Objective To compare amniotic fluid (AF) soluble nucleo-some levels in pregnant women with and without intra-amniotic infection. Methods Amniocentesis was performed in 74 pregnant women with preterm contractions, labor, or premature rupture of membranes. Intra-amniotic infection was defined as a positive AF culture. Amniotic fluid tests for Gram stain, glucose, neutrophils, creatinine, pH, and specific gravity were performed. Amniotic fluid soluble nucleosome levels were determined by enzyme-linked immunosorbent assay and were normalized by AF creatinine levels. Results Twenty-eight patients had intra-amniotic infection and 46 did not. Amniotic fluid soluble nucleosome levels were significantly higher in pregnant women with intra-amniotic infection than in those without infection (48.1±21.3 compared with 0.0 ± 0.0 U/mg creatinine; P = .005). The AF nucleosome levels were positively correlated with AF neutrophil counts and negatively correlated with AF glucose concentrations. Conclusion Our data indicate that elevated AF nucleo-some levels are associated with intra-amniotic infection and may have potential as a clinical marker to detect intra-amniotic infection. Pregnant women with intra-amniotic infection had significantly higher amniotic fluid soluble nucleosome concentrations than those without intra-amniotic infection.
Integrative computational biology for cancer research (2011)

Over the past two decades, high-throughput (HTP) technologies such as microarrays and mass spectrometry have fundamentally changed clinical cancer research. They have revealed novel molecular markers of cancer subtypes, metastasis, and drug sensitivity and resistance. Some have been translated into the clinic as tools for early disease diagnosis, prognosis, and individualized treatment and response monitoring. Despite these successes, many challenges remain: HTP platforms are often noisy and suffer from false positives and false negatives; optimal analysis and successful validation require complex workflows; and great volumes of data are accumulating at a rapid pace. Here we discuss these challenges, and show how integrative computational biology can help diminish them by creating new software tools, analytical methods, and data standards.
A robust FWI gradient for high-resolution velocity model building (2016)

We describe a robust method to produce long-wavelength updates in gradient-based Full Waveform Inversion (FWI). The gradient is computed by applying dynamic weights in the velocity sensitivity kernel derived from impedance and velocity parameterization of the classical objective function. The new kernel implementation effectively eliminates the migration isochrones produced by the specular reflections and emphasizes the low-wavenumber components in the gradient in heterogeneous media. The new gradient is able to provide velocity updates beyond penetration depth of diving waves. We use a synthetic example to illustrate how this dynamically weighted FWI gradient successfully recovers the background velocity from pre-critical reflections. We apply the new approach to 2D and 3D dual sensor data from deep-water Gulf of Mexico. Results show how the dynamically weighted FWI gradient can combine both transmitted and reflected energy in a global FWI scheme and provide high-resolution velocity models without migration imprint in the updates. Presentation Date: Tuesday, October 18, 2016 Start Time: 4:35:00 PM Location: 162/164 Presentation Type: ORAL
A Conjugate of a Tumor-Targeting Ligand and a T Cell Costimulatory Antibody To Treat Brain Tumors (2004)

T cell immunotherapy is a potential strategy for the treatment of brain tumors because it offers a high degree of specificity, the ability to extravasate into solid tumors, and the potential for eliciting a long-term protective immune response. Various approaches have been developed to overcome T cell immune tolerance to cancer, including the use of cytokines and bispecific antibodies. T cell stimulation with the proinflammatory cytokine IL-12 can elicit antitumor immunity. T cell activation can be increased using bispecific antibodies against activating molecules on the surface of T cells and a tumor antigen. We studied the effects of systemic IL-12 administration in combination with a conjugate of an anti-CD28 antibody and a ligand for the folate receptor. The high affinity folate receptor is expressed on endogenously arising choroid plexus tumors of SV11 mice, which are transgenic for large T antigen under the control of the SV40 promoter. SV11 mice are immunocompetent, yet immunologically tolerant to large T antigen expressed by choroid plexus tumors. MRI analysis showed that the administration of IL-12 and anti-CD28 Fab/folate significantly slowed tumor growth. Proliferating CD8(+) T cells were found in choroid plexus tumors of treated animals. Treatment of animals with IL-12 + anti-CD28 Fab/folate prolonged survival compared to IL-12 alone. Cytokine treatment combined with tumor-targeted costimulation may be a useful adjunct treatment.
Synthesis of phenyl‐substituted 2<i>H</i>‐3,4‐dihydro‐3‐aminomethyl‐1,4‐benzoxazines. Intermediates for 1<i>H</i>‐2,3,3a,4‐tetrahydroimidazo[5,1‐<i>c</i>][1,4]benzoxazin‐1‐one derivatives. Part II (1983)

Abstract The synthesis of 2 H ‐3, 4‐dihydro‐3‐aminomethyl‐1, 4‐benzoxazines substituted by one phenyl group in the 2, 3 or α‐position is reported. The two diastereoisomers of the 2‐phenyl‐derivative were independently synthesized from ethyl trans ‐3‐phenylglycidate by a stereospecific route. A previous attempt at the synthesis of these same compounds gave rise to an unexpected aliphatic‐aromatic ketone rearrangement.
SIG 2 Perspectives Vol. 23, No. 1, May 2013 (2013)

Sorry, this activity is no longer available for CEUs. Visit the SIG 2 page on the ASHA Store to see available CE activities. Use the CE questions PDF here as study questions to guide your Perspectives reading.
Decision-making under incomplete information: A B2B marketing perspective (2011)

This paper describes an empirical study concerning outsourcing of professional business services by organisations. Examples of such services include auditing, legal, management consulting, advertising, and IT services. They are indispensable to businesses, and virtually all companies outsource them at least once in a while, whereas many use them on a continuous basis. Professional business services are costly, and often directly impact the performance of the client’s core business. If executed well the service can add great value to the client’s operations. However, poor service quality could result in substantial financial losses for the service recipient. Hence choosing the right service provider is essential. However, at the time the outsourcing decision is being made, it is not clear, what the future service quality will be, because of the intangible and credence character of professional business services. Given also the high cost that such services typically involve, it is understandable that clients experience uncertainty and purchase risk when outsourcing them. Obviously this creates challenges for the buying organisation’s decision makers, since they need to make the important outsourcing decision under incomplete information about service quality.\nThis research examines how organisational buyers manage the risk inherent in outsourcing professional business services. This is done by means of identifying a set of factors that reduce this risk and predict the future value of the service. Prior research have shown that seller’s characteristics, purchase-related factors and relational variables are highly important in the outsourcing decision making process. The present study employed variables from these classes of factors to construct a conceptual model, and to test it, using mailing survey data and structural equation modelling. The results provide empirical support for the hypothesised linkages among the research constructs. The findings of this test are discussed and implications for management practice are outlined.
High Intensity Focused Ultrasound Ablation of the Vas Deferens in a Canine Model (2002)

We demonstrated the feasibility of noninvasive, transcutaneous high intensity focused ultrasound occlusion of the vas deferens with ablation powers at the upper end of the tested range, that is 7 W. Modifications of the hand held clip and optimization of ablation parameters would likely improve the success rate of this procedure. Refinement of this technology may provide a rapid noninvasive alternative to conventional vasectomy.
Auf dem Weg zu synthetischen Phosphodiesterasen: Supramolekularer Phosphoryltransfer, vermittelt durch Amidinium‐Phosphat‐Kontaktionenpaare (1992)

Räumliche Nähe und elektrophile Aktivierung wirken zusammen bei der Beschleungung der ring7ouml;ffenden Umesterung von 1 durch den Amidiniumalkohol 2. Die räumliche Nähe tritt in einem kontaktionenpaar aus 1 und 2 auf. Die elektrophile Aktivierung führt nicht nur dazu, daß 1 mit 2 9000mal schneller reagiert als mit Phenylethoanol, sondern auch dazu, daß durch Zusatz von 2 die Reaktion von 1 mit Phenylethonol zu 3 25mal schneller wird. magnified image
The elusive malaria sporozoite in the mammalian host (2004)

Malaria infection is initiated when Plasmodium sporozoites are injected into a host during the bite of an infected mosquito. In the mammal, the sporozoite must rapidly reach an intravacuolar niche within a hepatocyte, where it will generate the parasite stage that invades red blood cells and causes the symptoms of the disease. Herein, we describe our understanding of the way in which sporozoites travel from the site of the mosquito bite to the liver, arrest in the liver, cross the sinusoidal barrier and eventually gain access to hepatocytes. We also highlight some of the recent advances in our understanding of these processes at the molecular level.
Simulation and analysis of a reentrant planar magnetron (1987)

The self-consistent PIC code MAGIC, has been used to simutate a planar magnetron with a reentrant boundary condition. The dimensions of the gap and slow-wave structure were selected to give a pi-mode resonance at 18 GHz. Simulations of a ten-vane structure were performed both with and without energy extraction. As a result of the soliton theory applied to the Cross Field Devices (CFD's) the early time behavior of the space-charge layer is thought to be dominated by a long wavelength modulational instability (1). A space harmonic analysis of the TM fields was performed to obtain the growth rates of the low order space harmonic modes. Phase locking of the electrons leads to enhanced RF fields as energy is exchanged. The enhanced electric fields promote growth of the shorter wavelength modes. In addition, a space harmonic analysis of the energy density was made to determine the power spectra of the space-charge layer. The observed power law is consistent with that predicted for the turbulent spectrum of an imcompressible fluid.
Quantification of skeletal muscle mitochondrial function by<sup>31</sup><scp>P</scp>magnetic resonance spectroscopy techniques: a quantitative review (2014)

Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in vivo which is difficult to obtain in other ways. In skeletal muscle, non-invasive (31) P MRS measurements of the post-exercise recovery kinetics of pH, [PCr], [Pi] and [ADP] contain valuable information about muscle mitochondrial function and cellular pH homeostasis in vivo, but quantitative interpretation depends on understanding the underlying physiology. Here, by giving examples of the analysis of (31) P MRS recovery data, by some simple computational simulation, and by extensively comparing data from published studies using both (31) P MRS and invasive direct measurements of muscle O2 consumption in a common analytical framework, we consider what can be learnt quantitatively about mitochondrial metabolism in skeletal muscle using MRS-based methodology. We explore some technical and conceptual limitations of current methods, and point out some aspects of the physiology which are still incompletely understood.
Determination of optimal electrode positions for transcranial direct current stimulation (tDCS) (2008)

The present study introduces a new approach to determining optimal electrode positions in transcranial direct current stimulation (tDCS). Electric field and 3D conduction current density were analyzed using 3D finite element method (FEM) formulated for a dc conduction problem. The electrode positions for minimal current injection were optimized by changing the Cartesian coordinate system into the spherical coordinate system and applying the (2+6) evolution strategy (ES) algorithm. Preliminary simulation studies applied to a standard three-layer head model demonstrated that the proposed approach is promising in enhancing the performance of tDCS.
4,6-Diamino-1-alkyl-1,2-dihydro-s-triazines (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT4,6-Diamino-1-alkyl-1,2-dihydro-s-triazinesJoseph G. LombardinoCite this: J. Med. Chem. 1963, 6, 2, 213–214Publication Date (Print):March 1, 1963Publication History Published online1 May 2002Published inissue 1 March 1963https://doi.org/10.1021/jm00338a035RIGHTS & PERMISSIONSArticle Views87Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (263 KB) Get e-Alerts Get e-Alerts
Isoform-Specific Effects of Charged Residues at Borders of the M1−M2 Loop of the Na,K-ATPase α Subunit (1999)

The Na,K-ATPase is specifically inhibited by the cardiac glycoside, ouabain. Via a largely undefined mechanism, the ouabain affinity of the Na,K-ATPase can be manipulated by mutating the residues at the borders of the first extracellular (M1-M2) loop of the alpha subunit [Price, E. M., Rice, D. A., and Lingrel, J. B. (1990) J. Biol. Chem. 265, 6638-6641]. To address this issue, we compared the effects of two combinations of charged residues at the M1-M2 loop border, R113, D124 and D113,R124 (numbered according to the rat alpha1 subunit), on the ouabain sensitivity of the alpha1 and alpha2 isoforms. We report that ouabain sensitivity is dependent not only upon the identity of the residues at the M1-M2 loop border but also upon the context into which they are introduced. Furthermore, at low concentrations of ATP, the identity of the residues at the M1-M2 loop border affects the regulation of ATP hydrolysis by potassium in an isoform-specific manner. Analysis of chimeric alpha subunits reveals that the effects of potassium are determined primarily by the interaction of the N-terminus and M1-M2 loop with the C-terminal third of the alpha subunit. M1-M2 loop border residues may, therefore, influence ouabain sensitivity indirectly by altering the stability or structure of the intermediate of the Na,K-ATPase catalytic cycle which is competent to bind ouabain.
Phase II Study of Enzastaurin, a Protein Kinase C Beta Inhibitor, in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (2007)

Treatment with enzastaurin was well-tolerated and associated with prolonged FFP in a small subset of patients with relapsed or refractory DLBCL. Further studies of enzastaurin in DLBCL are warranted.
Application of the Continuous Annular Monitoring Concept To Prevent Groundwater Contamination by Class II Injection Wells (1990)

ABSTRACT This paper will present a continuous annular monitoring concept that allows Class II injection wells that have insignificant leaks in the casing to demonstrate mechanical integrity. Inherent in this concept is the premise that an insignificant leak in the casing is any leak that will not endanger a USDW and that this test will therefore meet the regulatory requirements under 40 CFR 146.8 (a) and (b). A case history will be presented to demonstrate the viability of this concept as an alternative mechanical integrity test. This concept has been approved as an alternate mechanical integrity test by the Regional Administrator of USEPA Region 6 for use in the Osage Mineral Reserve under 40 CFR 147.2912 (a)(1)(V).
ChemInform Abstract: Zinc Iodates — Infrared and Raman Spectra, Crystal Structure of Zn(IO<sub>3</sub>)<sub>2</sub>×2H<sub>2</sub>O. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wideband and wide scan phased array micro- strip patch antennas for small platforms (2007)

The paper presents an overview of research results from FOI on wideband and wide angular coverage, phased array microstrip patch antennas. The research has been motivated by their potential use in future applications in radar, multi- band satellite communication, electronic warfare, and multifunction systems. The paper presents the design and experimental evaluation of planar and faceted conformal antenna arrays using rectangular patch and bowtie microstrip elements. Both types can be designed for wide bandwidth and low weight using low cost PCB-technology. The array performance has been modelled using infinite array approximations and small finite arrays with Ansoft HFSS and an in-house developed FDTD code. The array designs have been experimentally characterized regarding circuit properties, such as active reflection coefficient, and radiation properties, including active element patterns and embedded array gain. (6 pages)
Characterization of lymphocytic choriomeningitis virus-binding protein(s): a candidate cellular receptor for the virus (1992)

The attachment of lymphocytic choriomeningitis virus (LCMV) to murine and primate cell lines was quantitated by a fluorescence-activated cell sorter assay in which binding of biotinylated virus was detected with streptavidin-fluorescein isothiocyanate. Cell lines that were readily infected by LCMV (e.g., MC57, Rin, BHK, Vero, and HeLa) bound virus in a dose-dependent manner, whereas no significant binding was observed to lymphocytic cell lines (e.g., RMA and WIL 2) that were not readily infected. Binding was specific and competitively blocked by nonbiotinylated LCMV. It was also blocked by LCMV-specific antiserum and a neutralizing monoclonal antibody to the virus glycoprotein GP-1 but not by antibodies specific for GP-2, indicating that attachment was likely mediated by GP-1. Treatment of cells with any of several proteases abolished LCMV binding, whereas phospholipases including phosphatidylinositol-specific phospholipase C had no effect, indicating that one or more membrane proteins were involved in virus attachment. These proteins were characterized with a virus overlay protein blot assay. Virus bound to protein(s) with a molecular mass of 120 to 140 kDa in membranes from cell lines permissive for LCMV but not from nonpermissive cell lines. Binding was specific, since unlabeled LCMV, but not the unrelated enveloped virus herpes simplex virus type 1, competed with 125I-labeled LCMV for binding to the 120- to 140-kDa band. The proteinaceous nature of the LCMV-binding substance was confirmed by the lack of virus binding to proteinase K-treated membrane components. By contrast, glycosidase treatment of membranes did not abolish virus binding. However, in membranes treated with endoglycosidase F/N-glycosidase F, and/or neuraminidase and in membranes from cells grown in tunicamycin, the molecular mass of the LCMV-binding entity was reduced. Hence, LCMV attachment to rodent fibroblastic cell lines is mediated by a glycoprotein(s) with a molecular mass of 120 to 140 kDa, with complex N-linked sugars that are not involved in virus binding.
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family (2000)

The Drosophila segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a Drosophila Wnt (Wnt) family member. Mouse and Xenopus homologs of porc (Mporc and Xporc) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with porc, four different types of Mporc and Xporc mRNA (A–D) are generated from a single gene by alternative splicing. Mporc mRNA is differentially expressed during embryogenesis and in various adult tissues, demonstrating that the alternative splicing is regulated to synthesize the specific types of Mporc. In transfected mammalian cells, all Mporc types affect the processing of mouse Wnt 1, 3A, 4, 6, and 7B but not 5A. Furthermore, all Mporc types are co-immunoprecipitated with various Wnt proteins. These results suggest that Mporc may function as a chaperone-like molecule for Wnt. Interestingly, all Mporc types can substitute for Porc, as they are able to rescue the phenotypes of Drosophila porc embryos. Consistent with this observation, Mporc, like Porc, modifies the processing of Wg expressed in mammalian cells. These results demonstrate that the porc gene family encodes the multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family.
Vibration characteristic identification by experiment of a new disc-type ultrasonic stator (2002)

The objective of this paper is to gain a deeper understanding of the vibration characteristics on the surface of a new disc-type ultrasonic stator for possible application to a moving object. By using the laser heterodyne technique, we can identify the vibration displacement and velocity patterns of the stator. Furthermore, the sensitivity is acquired from the measurement data. As a result, we find that the stator can produce a levitation motion on the surface of the stator. However, this is better for a lateral motion than a planar levitation.
Raman resonance and orientational order in fibers of single-wall carbon nanotubes (2002)

Polarized Raman spectroscopy is used to study Raman resonance and orientational order in fibers of single-wall carbon nanotubes. The polarized Raman intensity follows essentially the same angle dependence for both radial breathing mode and tangential modes and for both semiconducting and metallic nanotubes. A simple resonant model is proposed, which provides good fits of the whole vertical-vertical and vertical-horizontal data in different kinds of fibers. The model is used to describe orientational order of nanotubes in anisotropic fibers.