gebhart/patrepeval huggingface dataset:
Sustainable operation and management of data center chillers using temporal data mining (2009)

Motivation: Data centers are a critical component of modern IT infrastructure but are also among the worst environmental offenders through their increasing energy usage and the resulting large carbon footprints. Efficient management of data centers, including power management, networking, and cooling infrastructure, is hence crucial to sustainability. In the absence of a 'first-principles' approach to manage these complex components and their interactions, data-driven approaches have become attractive and tenable.
A Novel High Mechanical Property PLGA Composite Matrix Loaded with Nanodiamond–Phospholipid Compound for Bone Tissue Engineering (2015)

A potential bone tissue engineering material was produced from a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), loaded with nanodiamond phospholipid compound (NDPC) via physical mixing. On the basis of hydrophobic effects and physical absorption, we modified the original hydrophilic surface of the nanodiamond (NDs) with phospholipids to be amphipathic, forming a typical core-shell structure. The ND-phospholipid weight ratio was optimized to generate sample NDPC50 (i.e., ND-phospholipid weight ratio of 100:50), and NDPC50 was able to be dispersed in a PLGA matrix at up to 20 wt %. Compared to a pure PLGA matrix, the introduction of 10 wt % of NDPC (i.e., sample NDPC50-PF10) resulted in a significant improvement in the material's mechanical and surface properties, including a decrease in the water contact angle from 80 to 55°, an approximately 100% increase in the Young's modulus, and an approximate 550% increase in hardness, thus closely resembling that of human cortical bone. As a novel matrix supporting human osteoblast (hFOB1.19) growth, NDPC50-PFs with different amounts of NDPC50 demonstrated no negative effects on cell proliferation and osteogenic differentiation. Furthermore, we focused on the behaviors of NDPC-PFs implanted into mice for 8 weeks and found that NDPC-PFs induced acceptable immune response and can reduce the rapid biodegradation of PLGA matrix. Our results represent the first in vivo research on ND (or NDPC) as nanofillers in a polymer matrix for bone tissue engineering. The high mechanical properties, good in vitro and in vivo biocompatibility, and increased mineralization capability suggest that biodegradable PLGA composite matrices loaded with NDPC may potentially be useful for a variety of biomedical applications, especially bone tissue engineering.
Windowness and Human Behavior in the Hospital Rehabilitation Environment. (1983)

In hospitals, patients and staff are increasingly subjected to poorly windowed rooms. Six Physical Medicine and Rehabilitation Units in Chicago served as the research settings for a study of well-being as a function of personal factors and the basic functions of the window. Subjects numbered 150 and 125, respectively, for staff and patients. Using multidimensional scaling twenty cognitive dimensions of windowness were identified. Dimensions that address meaningful views, daylighting, and access to nature are highly desired. The dimensions that address windowless spaces were least preferred. The second half of the study explored well-being as a function of personal characteristics and six functions of the window of most direct consequence in rehabilitation. Certain types of patients were found to be susceptible to the effects of windowness. Close proximity to apertures that afford interesting view information, as facilitated by sufficiently low sills to afford perceptual access, is of high priority in terms of patient well-being. Patients, in general, are much more susceptible than hospital staff to the effects of insufficient involvement with the six window functions studies. By contrast, staff are better-equipped to engage in adequate compensatory measures to counter the informational deficiencies associated with poorly windowed working conditions. The findings have implications in terms of fundamental form determinants in the design of health care environments, including facility siting, scale, configuration, fenestration, and the location of internal units. Design recommendations address the informational affordances of windows in rehabilitation. Study limitations and areas warranting further investigation are discussed.
Membrane structure and interactions of human catestatin by multidimensional solution and solid‐state NMR spectroscopy (2010)

Catestatin is a natural peptide of higher organisms including humans, with a wide variety of biological functions involved in catecholamine inhibition, cardiovascular regulation, control of blood pressure, inflammation, and innate immunity. It is derived from the natural processing of chromogranin A, induced in the skin after injury, and produced by chromaffin cells and neutrophils. With neutrophils, the peptide enters the cell by crossing the plasma membrane where it interacts with internal targets to induce calcium influx. Therefore, we investigated the membrane interactions and structure of several catestatin-derived peptides. Whereas fluorescence dye release experiments are indicative of membrane permeabilization, multidimensional solution NMR and circular dichroism spectroscopies show that catestatin adopts alpha-helical conformations between Ser-6 and Tyr-12 in the presence of dodecylphosphocholine micelles. Furthermore, proton-decoupled (15)N solid-state NMR spectroscopy of sequences labeled with (15)N and reconstituted into oriented lipid bilayers indicates that this domain is aligned in a strongly tilted to inplanar alignment. Proton-decoupled (31)P NMR spectra of the same samples are indicative of conformational and/or orientational heterogeneity at the level of the lipid bilayer head groups due to the presence of catestatin. The sequence and 3-dimensional structure of catestatin exhibit homologies with penetratin, which is suggestive that they both enter the cells by related mechanisms to target internal structures.
Pyrochlores. VII. The Oxides of Antimony: an X-Ray and Mössbauer Study (1972)

Antimonic acid cannot be dehydrated by heating in air to give products of constant and reproducible weight without simultaneous reduction of some of the Sb V to Sb III . Neither anhydrous Sb 2 O 5 nor the hydroxy oxide Sb 3 O 6 OH postulated by Dihlström and Westgren can be obtained by this method. Two well-defined products of the dehydration/decomposition are Sb 2 O 4.35(5) = Sb 6 O 13 , which forms between 650 and 850°, and β-Sb 2 O 4 . The latter, and not Sb 2 O 3 , results on heating Sb 6 O 13 to 935°. Sb 6 O 13 has a cubic structure of the defect pyrochlore type, a 0 = 10.303(1) Å, x(O 2 ) = 0.4304(14). Combined evidence from X-ray diffractometry, density determination, and Mössbauer spectroscopy leads to Sb 3+ Sb 5+ 2 O 6 O 0.5 as the most probable structural formula.The Mössbauer parameters of β-Sb 2 O 4 are closely similar to those reported for α-Sb 2 O 4 , but the isomer shifts (relative to InSb at 77°K) for Sb V in antimonic acid and Sb 6 O 13 are significantly larger than those in α- and β-Sb 2 O 4 .
Effect of Ginkgo biloba on Blood Pressure and Incidence of Hypertension in Elderly Men and Women (2010)

Our data indicate that G. biloba does not reduce BP or the incidence of hypertension in elderly men and women.
RELATIONS BETWEEN ROTATORY POWER AND STRUCTURE IN THE SUGAR GROUP. XXX. THE ALPHA AND BETA METHYL-d-GALACTOSIDES AND THEIR TETRA-ACETATES<sup>1</sup> (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRELATIONS BETWEEN ROTATORY POWER AND STRUCTURE IN THE SUGAR GROUP. XXX. THE ALPHA AND BETA METHYL-d-GALACTOSIDES AND THEIR TETRA-ACETATES1J. K. Dale and C. S. HudsonCite this: J. Am. Chem. Soc. 1930, 52, 6, 2534–2537Publication Date (Print):June 1, 1930Publication History Published online1 May 2002Published inissue 1 June 1930https://pubs.acs.org/doi/10.1021/ja01369a056https://doi.org/10.1021/ja01369a056research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nanosecond-Pulsed DBD Plasma-Generated Reactive Oxygen Species Trigger Immunogenic Cell Death in A549 Lung Carcinoma Cells through Intracellular Oxidative Stress (2017)

A novel application for non-thermal plasma is the induction of immunogenic cancer cell death for cancer immunotherapy. Cells undergoing immunogenic death emit danger signals which facilitate anti-tumor immune responses. Although pathways leading to immunogenic cell death are not fully understood; oxidative stress is considered to be part of the underlying mechanism. Here; we studied the interaction between dielectric barrier discharge plasma and cancer cells for oxidative stress-mediated immunogenic cell death. We assessed changes to the intracellular oxidative environment after plasma treatment and correlated it to emission of two danger signals: surface-exposed calreticulin and secreted adenosine triphosphate. Plasma-generated reactive oxygen and charged species were recognized as the major effectors of immunogenic cell death. Chemical attenuators of intracellular reactive oxygen species successfully abrogated oxidative stress following plasma treatment and modulated the emission of surface-exposed calreticulin. Secreted danger signals from cells undergoing immunogenic death enhanced the anti-tumor activity of macrophages. This study demonstrated that plasma triggers immunogenic cell death through oxidative stress pathways and highlights its potential development for cancer immunotherapy.
Principle and Application of QCW-1A Controllability-Stability Tester for Automobiles (1993)

<div class="htmlview paragraph">This paper discusses the design features of QCW-1A tester. By selection and conversion of the coordinate systems, the feasibility that the strapdown mounting of gyroscope and accelerometer directly in the moving bodies replaces the mechano-electric platform is explained. Several problems affecting the measuring accuracy and measures used for improving accuracy are analysed. The performances of the unit are tested in the laboratory and in the automobile. Finally, the comparative curves of QCW-1A with U.S. SA-07 inertial tester are given.</div>
Statins for multiple sclerosis (2010)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the efficacy and safety of statins used alone or as add‐on to approved treatments for MS.
Myosin types and fiber types in cardiac muscle. I. Ventricular myocardium. (1981)

Antisera against bovine atrial myosin were raised in rabbits, purified by affinity chromatography, and absorbed with insolubilized ventricular myosin. Specific anti-bovine atrial myosin (anti-bAm) antibodies reacted selectively with atrial myosin heavy chains, as determined by enzyme immunoassay combined with SDS-gel electrophoresis. In direct and indirect immunofluorescence assay, anti-bAm was found to stain all atrial muscle fibers and a minor proportion of ventricular muscle fibers in the right ventricle of the bovine heart. In contrast, almost all muscle fibers in the left ventricle were unreactive. Purkinje fibers showed variable reactivity. In the rabbit heart, all atrial muscle fibers were stained by anti-bAm, whereas ventricular fibers showed a variable response in both the right and left ventricle, with a tendency for reactive fibers to be more numerous in the right ventricle and in subepicardial regions. Diversification of fiber types with respect to anti-bAm reactivity was found to occur during late stages of postnatal development in the rabbit heart and to be influenced by thyroid hormone. All ventricular muscle fibers became strongly reactive after thyroxine treatment, whereas they became unreactive or poorly reactive after propylthiouracil treatment. These findings are consistent with the existence of different ventricular isomyosins whose relative proportions can vary according to the thyroid state. Variations in ventricular isomyosin composition can account for the changes in myosin Ca2+-activated ATPase activity previously observed in cardiac muscle from hyper- and hypothyroid animals and may be responsible for the changes in the velocity of contraction of ventricular myocardium that occur under these conditions. The differential distribution of ventricular isomyosins in the normal heart suggests that fiber types with different contractile properties may coexist in the ventricular myocardium.
Optimization of PECT system for defect detection on aircraft riveted structures (2011)

Pulsed eddy current non-destructive testing (PECT) has been proved to be the most effective method for defect detection on aircraft riveted structures. In this paper, a study of PECT system optimization was made using “Method of Phase-shift and Logic-operation” (MPL) and DDS technique on the basis of analysis about the effects that system parameters exert upon the inspecting results. A novel auto-differentially rotary sensor for defect detection on riveted structures was proposed and presented from structure designing and working principle. The advantages and key performances of the optimized system were analyzed and PECT experiments on the specimen of rivet structures are carried out. The experimental results testify the availability of the optimized system and the necessity to optimize the PECT system parameters.
The Jeremiah Metzger Lecture. Vaccine prophylaxis today: its science, application and politics. (1998)

In summary, I have addressed 5 key issues concerning vaccines today. First is the essentially empiric nature of vaccinology. Vaccinology is not a rational science. Each idea must be tested by experiment. This need for trial and error experimentation is a substantial barrier to new vaccines. The proven track record of existing vaccines to eradicate disease, to reduce occurrence of disease, reduce human suffering and contain health care spending--when coupled with the potential for new discoveries against significant disease targets--is unparalleled by other therapeutic areas. The complexity of vaccine delivery today in clinical practice with 15-17 injections in the first two years of life emphasizes the need for development of combination pediatric vaccines, for example, putting DTaP, HBV, HIB, and IPV together. This has proved to be far more difficult than previously believed due to unpredicted immune interference and incompatibilities on mixing of different components, demonstrating again the inadequacy of our understanding of how vaccines work and the empiric nature of the science. Similar complexity will face adult vaccines in the future, as new adult vaccines are developed. Next, vaccines remain undervalued by people, by government, and by society. Government-controlled prices in many areas of the world prohibit a return on investment that supports innovative R&D. New vaccines may be unavailable in certain markets because of pricing restraints. Prices of new vaccines in the developed world will rise as will prices in the developing world for products currently available only in the developed world. Reluctance to use vaccines is an especially disturbing symptom of the undervaluation issue. In the U.S., school entry requirements have kept childhood immunization rates high by five years of age. But this is a new phenomenon, driven in part by the measles outbreaks. The risk is that history will repeat itself. In the absence of disease and lack of public knowledge of these diseases, complacency sets in, immunization rates fall, with the expected result on occurrence of disease. For adults, we may hope that managed care with its interest in cost saving and disease prevention may actually help in achieving the goals of the Year 2000. Finally, I have talked about the anti-vaccine attitudes and forces that impede control of disease by vaccines. It is important that new initiatives be undertaken that will be successful in providing a balanced view of vaccine safety, efficacy and benefits to the public, to the provider and to the payers.
Activation of c‐Jun‐N‐terminal‐kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers (2003)

The unselective cyclooxygenase (COX) inhibitor S-flurbiprofen and its-in terms of COX-inhibition-"inactive" enantiomer R-flurbiprofen have been previously found to inhibit tumor development and growth in various animal models. The underlying mechanisms are unknown. Here, we show that both R- and S-flurbiprofen reduce survival of three colon cancer cell lines, which differ in the expression of COX-2 (HCT-15, no COX-2; Caco-2, inducible COX-2; and HT-29, constitutive COX-2). The IC50 for S- and R-flurbiprofen ranged from 250 to 450 microM. Both flurbiprofen enantiomers induced apoptosis in all three cell lines as indicated by DNA- and PARP-cleavage. In addition, R- and S-flurbiprofen caused a G1-cell cycle block. The latter was associated with an activation of c-Jun N-terminal kinase (JNK), an increase of the DNA binding activity of the transcription factor AP-1 and down-regulation of cyclin D1 expression. Western blot analysis, as well as supershift experiments, revealed that the AP-1 activation was associated with a change of AP-1 composition toward an increase of JunB. The JNK inhibitor SP600125 antagonized R- and S-flurbiprofen-induced AP-1 DNA binding, suppression of cyclin D1 expression, and the G1-cell cycle block. However, JNK inhibition had no effect on flurbiprofen-induced apoptosis. Hence, the cell cycle arrest is obviously mediated, at least in part, through JNK-activation, whereas R- and S-flurbiprofen-induced apoptosis is largely independent of JNK. Although in vitro effects of R- and S-flurbiprofen were indistinguishable, only R-flurbiprofen inhibited HCT-15 tumor growth in nude mice, suggesting the involvement of additional in vivo targets, which are differently affected by R- and S-flurbiprofen.
The Free Radical Trapping Agent N-<i>Tert</i>.-Butyl-α-Phenylnitrone (PBN) Attenuates Cerebral Ischaemic Injury in Gerbils (1991)

Several studies have suggested that oxygen-derived free radicals play an important role in the genesis of ischaemia-induced neuronal damage. We report here that the spin trap agent, N-tert.-butyl-alpha-phenylnitrone (PBN) reduced neuronal damage in gerbils subjected to forebrain ischaemia. PBN (100 mg/kg) administered either 30 min. prior to, or 30 min. after a 5 min. period of bilateral carotid occlusion prevented the increase in locomotor activity observed in saline-injected ischaemic animals and significantly reduced the damage to the hippocampal CAI pyramidal cell layer observed 5 days post-ischaemia. Telemetry measurements of body temperature revealed that administration of PBN and the induction of cerebral ischaemia were associated with small reductions in body temperature, but these changes were not significant. PBN (100 mg/kg) administered 2 hr post-ischaemia failed to protect against cerebral ischaemia. These findings support the hypothesis of an involvement of free radicals in ischaemia-reperfusion induced cerebral damage and suggest that spin trap agents may be useful for the prevention of cerebral ischaemic damage.
Analysis of Compounds in Human Breath after Ingestion of Garlic Using Proton-Transfer-Reaction Mass Spectrometry (1996)

After ingestion of raw garlic, the components allyl methyl sulfide (1), allyl methyl disulfide (2), diallyl sulfide (3), diallyl disulfide (4), diallyl trisulfide (7), dimethyl sulfide (8), and acetone (9) in the breath of a test person were analyzed over a time period of about 30 h by means of proton-transfer-reaction mass spectrometry. While the concentrations of 2−7 reached maxima shortly after ingestion of garlic and declined to baseline values within the next 2−3 h, concentrations of 1, 8, and 9 increased much more slowly and showed enhanced values even 30 h after garlic consumption. The strong increase of the concentration of acetone might be indicative of enhanced metabolism of serum cholesterol, triglycerides, and total lipids in the blood stream. Keywords: Breath gas analysis; garlic components; proton-transfer-reaction mass spectrometry (PTR-MS)
Properties, Diagnosis and Management of Cucumber green mottle mosaic virus (2008)

Cucumber green mottle mosaic virus (CGMMV), a species under the genus Tobamovirus, is an important viral pathogen affecting cucurbit crops in Asia and Europe. The virion is rod shaped particle of 300 × 15 nm containing positive sense ssRNA of 6.4 kb as its genome. No insect vector is known to transmit the virus in a specific manner. The virus is highly stable, contagious and sap transmissible. Several isolates have been described from different countries in Eurasian regions infecting important cucurbits such as bottle gourd (Lagenaria siceraria), cucumber (Cucumis sativus), gherkin (Cucumis anguria), muskmelon (Cucumis melo) and watermelon (Citrullus vulgaris). Symptomatology of the virus is characterized by systemic green mottle mosaic on foliage. Some of the isolates induce serious fruit symptoms such as pulp deterioration (‘blood flesh’ disease) in watermelon. The complete genome of CGMMV is composed of 6424 nucleotides containing four open reading frames encoding replicase proteins, movement protein and coat protein. The CGMMV isolates form a distinct evolutionary clade separated from the other cucurbit-infecting tobamovirus species. Several sensitive methods are available for reliable diagnosis of CGMMV of which ELISA and RT-PCR are commonly used. Immunofilter paper assay and bioelectric recognition assay have been shown for rapid test of CGMMV. Control of CGMMV is difficult as commercial cultivars are susceptible. Limited source of resistance is known in muskmelon and wild Cucumis spp. The transgenic approach holds a greater potential in developing resistant varieties against CGMMV in any cucurbit.
Effects of 30 Mev Electron Irradiation on InGaAsP LEDs (Light Emitting Diodes) and InGaAs Photodiodes. (1986)

InGaAsP LEDs and InGaAs photodiodes were irradiated with a 30 MEV electron beam. The rate of performance degradation were studied. Simple models for LED and photodiode current controlling mechanisms and for a phenomenological radiation damage constant are presented. The dominant current controlling mechanisms and the peak wavelength of the LEDs and photodiodes did not change during irradiation.
Genetics of glioma (2016)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Shallow Meridional Circulation in the Tropical Eastern Pacific* (2003)

Based on four independent datasets, this study presents observational evidence of a shallow meridional circulation cell in the eastern tropical Pacific. In this shallow meridional circulation cell the northerly cross-equatorial return flow from the ITCZ into the Southern Hemisphere is found immediately above the atmospheric boundary layer, in contrast to the classic concept of the Hadley-type deep meridional circulation whose northerly return flow resides in the upper troposphere. The strength and depth of this shallow meridional circulation undergo a distinct annual cycle. Possible causes and climatic implications of this shallow meridional circulation are discussed.