gebhart/patrepeval huggingface dataset:
Programming Multiple Protein Patterns on a Single DNA Nanostructure (2007)

Pyrrole−imidazole polyamide−biotin conjugates recruit protein to uniquely addressable sites on a four tile DX array. Conjugates in combination lead to unique patterns with distinct spacing. Polyamide binding is sequence specific and requires no structural or chemical modification of the target DNA allowing the same DNA template to be used to create a variety of assemblies.
Exploring Hardware Profile-Guided Green Datacenter Scheduling (2015)

Recently, tapping into renewable energy sources has shown great promise in alleviating server energy poverty and reducing IT carbon footprint. Due to the limited, time-varying green power generation, matching server power demand to runtime power budget is often crucial in green data centers. However, existing studies mainly focus on the temporal variability of the power supply and demand, while largely ignore the spatial variation issue in server hardware. With more complex computing units integrated and the technology scaling, the performance/power variation among nodes and the conservative supply voltage margin of each core can greatly compromise the power matching effectiveness that a green datacenter can achieve. This paper explores green datacenter design that takes into account non-uniform hardware power characteristics. We propose is cope, a novel power management framework that can (1) expose architecture variability to the datacenter facility-level scheduler for efficient power matching, and (2) balance the energy usage and lifetime of compute nodes in the highly dynamic green computing environment. Using realistic hardware profiling data and renewable energy data, we show that is cope can reduce the energy cost up to 54%, while maintaining fairly balanced processor utilization rate and negligible profiling overhead.
Preventing and treating orthostatic hypotension: As easy as A, B, C (2010)

Orthostatic hypotension is a chronic, debilitating illness that is difficult to treat. The therapeutic goal is to improve postural symptoms, standing time, and function rather than to achieve upright normotension, which can lead to supine hypertension. Drug therapy alone is never adequate. Because orthostatic stress varies with circumstances during the day, a patient-oriented approach that emphasizes education and nonpharmacologic strategies is critical. We provide easy-to-remember management recommendations, using a combination of drug and nondrug treatments that have proven efficacious.
OVERVIEW OF TOP-K QUERY PROCESSING IN RELATIONAL DATABASES (2011)

Query processing is a fundamental part of Database management system. As the amount of text data stored in relational databases is increasing, it is necessary to support the Top-k query processing over text data. The main objective of top-k query processing is to return the k highest ranked results quickly and efficiently. In this paper, we introduce the Top-k query processing in relational database system. We also discuss the classification of Top-k query processing techniques in relational databases with different design dimensions.
Membrane localization is not required for Mpl function in normal hematopoietic cells (2001)

Cellular trafficking of growth factor receptors, including cross-talk among receptors at the cell surface, may be important for signal transduction in normal hematopoietic cells. To test this idea, the signaling domain of Mpl (the thrombopoietin receptor) was targeted to the plasma membrane, or to the cytoplasm of murine marrow cells, and the ability of the cells to proliferate and differentiate in response to Mpl dimerized at the plasma membrane or free in the cytoplasm was assessed. Constructs encoding the signaling domain of Mpl linked to an FK506 binding protein domain (to permit dimerization by the membrane-permeable ligand AP20187) with or without a myristylation sequence (to target the receptor to the plasma membrane) and a hemagglutinin epitope tag were generated and introduced into murine marrow cells using a murine stem cell virus (MSCV)-based retroviral vector. Both populations of transduced marrow cells proliferated in Iscoves modified Dulbecco medium-10% FCS-100 nM AP20187 without exogenous growth factors for more than 100 days and achieved greater than a 10(7)-fold expansion of cells by day 50 (n = 4 transductions). Growth was dimerizer dependent, and myeloid, erythroid, and megakaryocytic progenitors were generated. Activation of Mpl either at the plasma membrane or in the cytoplasm allowed for the terminal maturation of transduced progenitor cells. Introduction of membrane-targeted or cytoplasmic Mpl into fetal liver cells from homozygous JAK2 knock-out mice or wild-type littermates demonstrated that both forms of Mpl require JAK2 for signaling. These data show that the activation of Mpl independent of its normal plasma membrane location can support production of the full range of normal hematopoietic progenitor cells in vitro.
A low-noise, wide-band CMOS charge-sensitive preamplifier for use with APD/LSO PET detectors (1996)

The recent emergence of LSO as a potential scintillator for positron emission tomography (PET) and recent improvements in avalanche photodiode (APD) technology offer encouragement that an APD/LSO based PET detector may be commercially viable in the near future. An important component of any APD/LSO based PET detector will be the preamplifier used to read out the low-level detector signals. Due to the large number of detectors (>18,000) in a high-resolution PET scanner, the preamplifier must be implemented as a monolithic integrated circuit. Additionally, in order to achieve the timing resolution required for high resolution PET, the preamplifier must have a large band-width and a low equivalent input noise voltage. This paper presents a CMOS charge-sensitive preamplifier design which uses local feedback to improve the performance of the common gate transistor. The modified cascode circuit is analyzed and compared with a previously reported simple folded cascode circuit. A prototype circuit was fabricated in a 2 /spl mu/m NWELL CMOS process. The prototype amplifier has a measured 10-90% rise-time of 7 ns with an external input capacitance of /spl sim/6 pF and has an equivalent input noise voltage of /spl sim/1.1 nV/rt-Hz above the flicker noise corner. A pulse height resolution of 14.3% FWHM and a timing resolution of 1.57 ns FWHM (vs. Plastic) were obtained with the preamplifier, an Advanced Photonix 5 mm diameter beveled-edge APD and 3.5/spl times/3.5/spl times/22 mm/sup 3/ Teflon wrapped LSO crystal.
Discordant Secretion of Placental Protein Hormones in Differentiating Trophoblasts<i>in Vitro</i> (1989)

The regulation of trophoblast secretion of the placental proteins CG (hCG), placental lactogen (hPL), and pregnancy specific-beta-1-glycoprotein (SP-1) has not been fully elucidated. We therefore studied the secretion of hCG, hCG-beta subunit, hCG-alpha subunit, hPL, and SP-1, both in the basal state and after exposure to 8-bromo-cAMP, during the in vitro differentiation of cytotrophoblasts to syncytiotrophoblasts. Term placental tissue was enzymatically digested and cytotrophoblasts purified by Percoll density gradient centrifugation. At the time of seeding of 4-6 X 10(5) cells/ml in 35-mm flasks all of the cells were mononuclear and 48% contained hCG-alpha, but none contained hCG or hCG-beta by the avidin-biotin-peroxidase immuno-histochemical method. After 3 days in culture, hCG-alpha and hCG or hCG-beta were present in multinucleated syncytiotrophoblasts and in the mononuclear cytotrophoblasts. During the 5 days in culture, the secretion of hCG, hCG-alpha, hPL and SP-1 into the media increased and reached a maximum on day 4 followed by a decrease on day 5. Basal hCG-beta secretion was very low and did not change during culture. The ratio of hCG-alpha/hCG decreased from days 1-4 of culture. Incubation with 8-bromo-cAMP for 24 h stimulated the secretion of hCG and hCG-alpha, whereas hCG-beta and hPL levels did not change. The secretion of SP-1, however, was inhibited by 8-bromo-cAMP. These results indicate that the cytotrophoblasts secrete hCG, hCG-beta and hCG-alpha during in vitro differentiation into syncytiotrophoblasts. Since the basal ratio of hCG to hCG-alpha secretion changed during 5 days in culture and a cAMP analogue differentially modulated the secretion of the different placental protein hormones, the physiological regulation of secretion of each of the proteins also may differ.
Rendering of Virtual Sound Sources with Arbitrary Directivity in Higher Order Ambisonics (2007)

Higher order Ambisonics (HOA) is a spatial audio reproduction technique aiming at physically synthesizing a desired sound field. It is based on the expansion of sound fields into orthogonal basis functions (spatial harmonics). In this paper we present an approach to the two-dimensional reproduction of virtual sound sources at arbitrary positions having arbitrary radiation directivities. The approach is based on the description of the directional properties of a source by a set of circular harmonics. Consequences of truncation of the circular harmonics expansion and spatial sampling as occurring in typical installations of HOA systems due to the employment of a finite number of loudspeakers are discussed. We illustrate our findings with simulated reproduction results.
The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli. (2010)

Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. Especially, carbapenem antibiotics are hydrolyzed more efficiency than other beta-lactam antibiotics. The KPC enzymes are found most often in Enterobacteriaceae. Recently, these enzymes have been found in isolates of Pseudomonas aeruginosa and Acinetobacter spp. The observations of blaKPC genes isolated from different species in other countries indicate that these genes from common but unknown ancestor may have been mobilized in these areas or that blaKPC-carrying bacteria may have been passively by many vectors. The emergence of carbapenem resistance in Gram-negative bacteria is worrisome because the carbapenem resistance often may be associated with resistance to many beta-lactam and non-beta-lactam antibiotics. Treatment of infections caused by KPC-producing bacteria is extremely difficult because of their multidrug resistance, which results in high mortality rates. Therapeutic options to treat infections caused by multiresistant Gram-negative bacteria producing KPC-carbapenemases could be used polymyxin B or tigecycline.
"COLO 357," a human pancreatic adenosquamous carcinoma: growth in artificial capillary culture and in nude mice. (1983)

The human pancreatic cancer cell line COLO 357 has been xenografted s.c. in athymic Swiss mice. The xenografts grew well to form typical adenosquamous carcinomas. The cells were placed in a perfused artificial capillary system where they formed a solid tumor mass which survived for 7 weeks. In this system, the cells consumed glucose and released enzymes and carcinoembryonic antigen into the extracapillary space.
Formulation and Evaluation of Solid Dispersions of an Anti-diabetic Drug (2009)

The present work investigates the dissolution and bioavailability characteristics of an anti-diabetic drug, Glimepiride. Glimepiride, is an oral hypoglycemic drug and has problems in bioavailability and bioequivalence due to its poor water solubility. In the present study, dissolution studies were carried out by using USP XXIV apparatus, for the drug glimepiride, and its binary systems (both physical mixture as well as solid dispersions of glimepiride). Infrared (IR) Spectroscopy, Differential Scanning Calorimetry (DSC), and X-ray Diffractometry (XRD) were performed to identify any physicochemical interaction between the drug and the carrier and its effect on dissolution behavior. Tablets containing solid dispersion products were formulated and compared with the commercial product. The commercial product and the tablet formulation under investigation were than characterized for their various physicochemical properties such as weight variation, % friability, disintegration and in vitro dissolution profiles. IR Spectroscopy, XRD, and DSC showed no change in the crystal structure of glimepiride thus indicating the absence of any interaction between the drug and the polymer. A significant improvement in the dissolution of glimepiride in solid dispersion products has been observed (>85% in 5 minutes). Also tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for the improvement of dissolution of glimepiride.
Labeling of Some C<sub>6</sub> Hydrocarbons by Exposure to Tritium (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLabeling of Some C6 Hydrocarbons by Exposure to TritiumPeter Riesz and Kenneth E. WilzbachCite this: J. Phys. Chem. 1958, 62, 1, 6–9Publication Date (Print):January 1, 1958Publication History Published online1 May 2002Published inissue 1 January 1958https://pubs.acs.org/doi/10.1021/j150559a003https://doi.org/10.1021/j150559a003research-articleACS PublicationsRequest reuse permissionsArticle Views49Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Demonstration of a large-area AlGaN/GaN Schottky barrier photodetector on Si with high detection limit (2013)

A high-quality AlGaN/GaN Schottky barrier photodetector was demonstrated on Si. The device exhibited a very low dark current of 0.94 fA at −2.5 V and 2.51 pA at −10 V. There were two spectral response peaks located at 280 and 340 nm, respectively, and the relative intensity of these peaks changed with applied bias. The responsivity exhibited optical power density dependence measured at 340 nm with different bias. The zero bias differential resistance of 3.63 × 1013 Ω and area product is calculated to be 4.10 × 1011 Ω cm2. The excellent current–voltage characteristics led to a detectivity performance of 4.98 × 1013 cm Hz1/2 W−1.
Role of Transforming Growth Factor-β1 in Cardiovascular Inflammatory Changes Induced by Chronic Inhibition of Nitric Oxide Synthesis (2000)

We previously reported that chronic inhibition of nitric oxide (NO) synthesis with N(omega)-nitro-L-arginine methyl ester (L-NAME) induces inflammatory changes (monocyte infiltration, myofibroblast formation, and monocyte chemoattractant protein-1 [MCP-1] and transforming growth factor-beta1 [TGF-beta1] expression) in the rat heart and vessel. There is debate regarding whether TGF-beta1 exhibits proinflammatory or anti-inflammatory activities. We used the rat model to investigate the role of TGF-beta in the pathogenesis of such inflammatory changes. We show here that infiltrating monocytes and myofibroblasts in the inflammatory lesions produced TGF-beta1 on the third day of L-NAME administration. Cotreatment with a monoclonal antibody against TGF-beta1, but not with control IgG, prevented the L-NAME-induced cardiac inflammation. The antibody also significantly inhibited the gene expression of MCP-1, P-selectin, and intercellular adhesion molecule-1. In summary, the antibody against TGF-beta1 prevented inflammatory changes in rat heart and vessel induced by chronic inhibition of NO synthesis, suggesting that increased production of TGF-beta1 is involved in the inflammatory changes in this model.
Culture of normal human leukocytes (1967)

Rapidly growing and apparently permanent cultures were established from hematopoietic cells from two staff members with no known malignant disease. The cell lines were similar to those derived from leukocytes from the peripheral blood of patients with malignancies of either hematopoietic or nonhematopoietic origin and to the lymphoblastoid cell lines derived from Burkitt's lymphoma. Both cell lines contained a herpetic-like virus (leukovirus), produced immunoglobulins, and grew rapidly in various suspension cultures.
Negative Thermal Expansion in ZrW<sub>2</sub>O<sub>8</sub> and HfW<sub>2</sub>O<sub>8</sub> (1996)

Isostructural ZrW2O8 and HfW2O8 show strong negative thermal expansion from 0.3 K up to their decomposition temperatures of approximately 1050 K. This behavior is especially unusual because these compounds are apparently cubic over their entire existence range. Detailed structural studies of ZrW2O8 were conducted using high-resolution neutron powder diffraction data taken at 14 temperatures from 0.3 to 693 K. Below 428 K, ZrW2O8 adopts the acentric space group P213 and has a well-ordered structure containing corner-sharing ZrO6 octahedra and two crystallographically distinct WO4 tetrahedra. Above the phase transition at 428 K, which appears to be second order, the space group becomes centric Pa3̄. The structure is now disordered with one oxygen site 50% occupied, suggesting the possibility of high oxygen mobility. Oxygen motion above 428 K is also suggested by dielectric and ac impedance measurements. The negative thermal expansion of ZrW2O8 and HfW2O8 is related to transverse thermal vibrations of bridging oxygen atoms. These lead to coupled rotations of the essentially rigid polyhedral building blocks of the structure. A semiquantitative model for both the negative thermal expansion and phase transition of these materials is proposed in light of the diffraction results.
Monitoring IGBT's health condition via junction temperature variations (2014)

Insulated gate bipolar transistor (IGBT) failures are a major issue in modern power electronics applications. Two most dominated failure mechanisms of IGBTs are solder fatigue and bond wire wear-out. This paper proposes a new method to online monitor an IGBT's health condition by using the instantaneous junction temperature variation between present and the first operating cycles of the IGBT with the same operating current. In this work, the instantaneous junction temperature of an IGBT is estimated from a thermal network model. The proposed method is validated by experimental results obtained from accelerated aging tests for IGBTs.
A Capillary Column for the Gas Chromatographic Analysis of Dicyclopentadiene (1971)

The production of dicyclopentadiene (DCPD) is generally accompished by the dimerization of cyclopentadiene (CPD) which progresses rapidly at a temperature of approximately 100°C. The purity if the DCPD is dependent upon the quality of the CPD feedstock. There is no known commercial process for the synthesis of CPD; the available supply amounting to approximately 100 MM pounds per year is recovered from hydrocarbon cracking and coking processes. The dimerization is a Diels-Alder addition in which one CPD molecule acts as the conjugated diolefin and another as the dienophile. The ability of CPD to function in this dual capacity results in the production of numerous codimers when other olefins and conjugated diolefins are present with CPD in the feed to the dimerizer. Analytical methods for determining the purity of DCPD are complicated by the presence of these codimers. Several GLC analytical procedures using various liquid phases which include polyglycols and modified polyglycols have been reported for the analysis of CPD and DCPD. Dahmen reported an analytical procedure which included the analysis of some codimers of CPD with other C5 acyclic diolefins. The mass spectrometric analysis of DCPD is subject to the usual problems arising from the presence of isomers of different molecular types, as in this situation: bicyclics and hydroindenes. Acceptable analyses of DCPD samples containing impurities such as codimers of CPD and butadiene, isoprene, piperylenes, and methylcyclopentadienes have been accomplished using capillary columns having m-bis(m-phenoxyphenoxy) benzene with 2% Apiezon L (MBMA) as a liquid phase.
[Detection of Epstein-Barr virus in lung carcinoma tissue by in situ hybridization]. (2007)

The frequency of EBV infection in this series of patients from Tangshan area was 33.3%, the results suggest that there is a relationship between EBV infection and the occurrence of the primary lung carcinoma, EBV infection might be one of the potential causes to induce lung cancer.
Hybrid SSD with PCM (2011)

Solid-State Drive, popularly known as SSD is now widely used in computer system and industry. This is a new type of memory which is smaller and lighter as compared to HDD. During a “clean” shutdown, most host systems, initiate a command (the STANDBY IMMEDIATE command) to an SSD to give the SSD enough time to prepare for the shutdown. This allows the SSD to save data currently in transition (in temporary buffers) to the non-volatile NAND media. However, during an unsafe power shutdown, the SSD abruptly loses power before the host system can initiate the STANDBY IMMEDIATE command. This prevents data in the temporary buffers from being saved in the non-volatile NAND. In this paper, we advance two new hybrid SSD architectures which are composed of PCM and NAND Flash. In these architectures, data loss during unplanned power shutdown can be avoided.
Hollow-core photonic bandgap fibre: new light guidance for new science and technology (2006)

We review the progress made on the fabrication and applications of hollow-core photonic crystal fibres (HC-PCFs). The mechanism of the light guidance in these fibres is described along with their dispersion properties. We review the HC-PCF fabrication, the different results achieved in the fields of laser-induced particle guidance, low-threshold stimulated Raman scattering in hydrogen (vibrational and rotational), laser frequency metrology and quantum optics. Finally, we show the different new prospects opened up by these fibres.
A Pixel Analog-Counting Single-Photon Imager With Time-Gating and Self-Referenced Column-Parallel A/D Conversion for Fluorescence Lifetime Imaging (2015)

A single-photon, time-gated, 160 × 120 pixel imager is presented for its application in fluorescence lifetime imaging microscopy. Exploiting single-photon avalanche diodes and an extremely compact pixel circuitry-only seven MOSFETs and one MOSCAP-the imager is capable of gathering information about photon position, number, and time distribution, enabling cost-effective devices for scientific imaging applications. This is achieved thanks to the photon counting and time-gating capabilities implemented in the analog domain, which in turn enable a 15 μm pixel with a 21% fill-factor. A reconfigurable column circuitry supports both the analog conventional readout and a self-referenced analog-to-digital conversion, able to cancel out the pixel-to-pixel nonuniformities, and speeding up the framerate to 486 fps. The imager, featuring also a delay locked loop to stabilize the internal waveform generation for reliable timing performance, has been implemented in a standard high-voltage 0.35 μm CMOS technology. Measurements in a fluorescent lifetime setup have been performed, comparing the results with single-point acquisitions made with commercial time-correlated equipment.