gebhart/patrepeval huggingface dataset:
Energy Transfer Between Two Peptides Bound to One MHC Class II Molecule (1991)

The 17-amino acid peptide from chicken ovalbumin, Ova(323-339), was labeled at the amino terminus with fluorescein [FOva(323-339)] and near the carboxyl terminus with Texas Red [AcOva(323-338)KTR]. Fluorescence spectroscopy was carried out on resolved electrophoretic bands on nonreducing polyacrylamide gels derived from incubation mixtures containing major histocompatibility complex (MHC) class II molecules IAd and the FOva(323-339)- and AcOva(323-338)KTR-labeled peptides. Energy transfer between fluorescein and Texas Red was observed in the "floppy" alpha beta heterodimer band, but not in the "compact" alpha beta heterodimer band. Energy transfer was detected between the truncated peptides FOva(323-328)CONH2 and AcOva(331-338)KTR in both the compact alpha beta and floppy alpha beta gel bands. The energy-transfer data suggest that the two binding sites of floppy alpha beta arise from splitting apart a putative large, single binding site region in compact alpha beta.
The chemistry of a polyamide–epichlorohydrin resin (hercosett 125) used to shrink‐resist wool (1985)

Abstract A polyamide–epichlorohydrin resin used to shrink‐resist wool [Hercosett 125 (Hercules Inc.)] was separated by ultrafiltration into fractions A, B, and C (in the approximate proportions 60, 40, and 2 by weight), which correspond to the three peaks in size exclusion chromatograms (SEC). Viscosity, spectra, and SEC results as well as results of experiments on the reaction of the parent polyamino–polyamide (PAA) with epichlorohydrin indicated that fraction A was high‐molecular‐weight crosslinked material whereas fraction B was essentially uncrosslinked. Fraction C was minor impurity, possibly a mixture containing a triazine, and it was also found in the PAA from which the original resin was prepared. High‐resolution proton NMR spectra of the Hercosett 125 indicated that chlorohydrin or epoxy groups were absent, and thus confirmed an earlier 13 C‐NMR study that only azetidinium reactive groups were present. Two reactions are believed to occur in Hercosett 125 on storage: hydrolysis of azetidinium to dihydroxypropyl groups and hydrolysis of backbone amides. The small differences in the properties of wool treated with either A or B fractions, and those of wool treated with unfractionated Hercosett 125, were related to the extent of crosslinking before and after curing. As the extent of crosslinking increased, the amount of staining by an anionic dye decreased, and the shrink resistance improved slightly.
Effects of the nanoimprint pattern on the performance of a MEMS-based micro direct methanol fuel cell (2008)

In this paper, nanoimprint technology is presented as an excellent candidate for replacing conventional graphite-based porous electrodes for a more compact and thinner micro direct methanol fuel cell (DMFC). High catalyst efficiency is realized in a MEMS-based passive micro DMFC by directly forming fine patterns on a polymer electrolyte membrane by the nanoimprint method. The MEMS-based micro DMFC has a maximum power density (MPD) of about 0.2 mW cm−2 with a Pt catalyst loading of about 0.04 mg cm−2. The MPD is much higher than those of the reported micro DMFCs with similar catalyst loading. We also investigated the relationship between the cell performance, the nanoimprinted patterns and the catalyst. A good match is necessary between the nanoimprinted patterns and the catalyst layer for high catalyst efficiency. It is mainly owing to the fact that the Pt catalyst layer plays the function of a current collector in the prepared MEMS-based micro DMFC. Higher performance could be enabled by improving the catalyst layer and the nanoimprinted patterns.
Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells (2011)

Protein kinase AKT mediates cell proliferation and survival signals, and also contributes to cancer progression. Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with those of the control cells 48 h after the herbal treatments. We found that terpinolene, a common component of sage and rosemary, markedly reduced the protein expression of AKT1 in K562 cells and inhibited cell proliferation.
Stable carbonium ions. LIII. Diprotonated aliphatic glycols and their rearrangement in fluorosulfonic acid-antimony pentafluoride solution (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable carbonium ions. LIII. Diprotonated aliphatic glycols and their rearrangement in fluorosulfonic acid-antimony pentafluoride solutionGeorge A. Olah and Jean SommerCite this: J. Am. Chem. Soc. 1968, 90, 4, 927–933Publication Date (Print):February 14, 1968Publication History Published online1 May 2002Published inissue 14 February 1968https://pubs.acs.org/doi/10.1021/ja01006a016https://doi.org/10.1021/ja01006a016research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lung Collagen Composition and Synthesis (1974)

In the lung, collagen is found associated with bronchi, with blood vessels, and with the alveolar interstitium; it is known to be fundamental in the maintenance of lung structure and function. Two collagen chains, α1 and α2, can be extracted from rabbit lung homogenates; each chain has an approximate molecular weight of 100,000 and is composed of amino acids that are characteristic of collagen, but are not specific for lung. Lung slices incubated in vitro synthesize α1 and α2 chains, as demonstrated by carboxymethylcellulose chromatography, by sodium dodecyl sulfate acrylamide gel electrophoresis, by acidic acrylamide gel electrophoresis, by sensitivity to collagenase, and by sensitivity to trichloroacetic acid at 90°. As a percentage of dry weight, lung protein does not change significantly during maturation, but the content of collagen increases 5-fold from the late stages of gestation to adult life. The average rate of collagen synthesis per cell decreases slowly 10-fold from fetal to adult life whereas the average rate of noncollagen protein synthesis per cell rapidly decreases to adult levels before birth. The rate of collagen synthesis relative to the rate of total protein synthesis is low in fetal life, rises from 2 to 15% in the first month of life, and then declines by 2 months of age to the fetal level throughout adult life. The maturing lung, therefore, has significant changes in genetic expression during a period of rapid growth as the lung converts to a gas-exchanging organ.
The aetiology and pathogenesis of endometriosis (1992)

It is 130 years since the first description of endometriosis and yet this enigmatic disease still continues to confound gynaecologists. In the last five years there has been evidence which suggests that endometriosis is a much more common finding in the pelvis than previously recognized and this has created conflict over the precise definition of the disease. Currently it is difficult for clinicians to be certain what constitutes endometriosis and what is the clinical and pathological significance of the visual diagnosis of the disease. This article will review the evidence about the pathological significance of the visual diagnosis of endometriosis. It will analyze the aetiological factors that predispose to the disease and evidence concerning its pathogenesis. Finally, it will discuss the evidence that points to a particular epithelium being the origin of endometriosis.
Proposal of application architecture in electronic commerce service between companies (2003)

This paper proposes the concept of a secure application architecture that helps a service provider to enterprise a business-to-business e-commerce service. Recently, there has been a paradigm shift to inter-enterprise integration. We have started a new service provider business for business media services that is based on two concepts: business process integration and high-grade security in response to variety types of cooperation. The infrastructure of this service can provide various services such as marketing, design, manufacturing, inspection, distribution, payment, and maintenance. In this paper, the proposed architecture is applied to a quotation support system that is used for three types of quotation in a procurement business, that is a specified, members, and general quotation. It will enable many companies to construct paper-less office systems easily and also to shorten the response time for quotations with documents like design specifications between buyers and vendors.
The application of systems engineering principles to the European DEMO design and R&amp;D studies (2013)

The European Fusion Roadmap [1] shows the DEMO concept design phase commencing in 2014. The early implementation of systems engineering principles within the EU DEMO programme is essential to provide a framework for achieving this long-term mission. The aim of the systems engineering approach is to clearly define and justify the research and development (R&D) necessary to deliver a credible EU DEMO concept design by 2020 that will meet the agreed DEMO system requirements. The approach will lead to increased efficiency in the deployment of limited R&D resources and will facilitate the necessary discussion and agreement amongst stakeholders. Furthermore, it will enable transparent prioritisation of the required R&D for the strategically important technologies for DEMO. A systems decision process (SDP) is presented that provides a systematic, objective and traceable method for evaluating DEMO technologies and designs according to their capability to meet the top-level system criteria for the overall DEMO plant. Two preliminary examples where this approach should be applied are discussed: (i) the choice of primary coolant and (ii) the extension of pulse duration through auxiliary current drive.
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein–methyltransferase superfamily (2001)

The retinoblastoma protein-interacting zinc finger gene RIZ (PRDM2) is a member, by sequence homology, of a nuclear protein-methyltransferase (MTase) superfamily involved in chromatin-mediated gene expression. The gene produces two protein products, RIZ1 that contains a conserved MTase domain and RIZ2 that lacks the domain. RIZ1 gene expression is frequently silenced in human cancers, and the gene is also a common target of frameshift mutation in microsatellite-unstable cancers. We now report studies of mice with a targeted mutation in the RIZ1 locus. The mutation inactivates RIZ1 but not RIZ2. These RIZ1 mutant mice were viable and fertile but showed a high incidence of diffuse large B-cell lymphomas (DLBL) and a broad spectrum of unusual tumors. RIZ1 deficiency also accelerated tumorigenesis in p53 heterozygous mutant mice. Finally, several missense mutations of RIZ1 were found in human tumor tissues and cell lines; one of these was particularly common in human DLBL tumors. These missense mutations, as well as the previously described frameshift mutation, all mapped to the MTase functional domains. All abolished the capacity of RIZ1 to enhance estrogen receptor activation of transcription. These data suggest a direct link between tumor formation and the MTase domain of RIZ1 and describe for the first time a tumor susceptibility gene among methyltransferases.
Event-based 3D SLAM with a depth-augmented dynamic vision sensor (2014)

We present the D-eDVS- a combined event-based 3D sensor - and a novel event-based full-3D simultaneous localization and mapping algorithm which works exclusively with the sparse stream of visual data provided by the D-eDVS. The D-eDVS is a combination of the established PrimeSense RGB-D sensor and a biologically inspired embedded dynamic vision sensor. Dynamic vision sensors only react to dynamic contrast changes and output data in form of a sparse stream of events which represent individual pixel locations. We demonstrate how an event-based dynamic vision sensor can be fused with a classic frame-based RGB-D sensor to produce a sparse stream of depth-augmented 3D points. The advantages of a sparse, event-based stream are a much smaller amount of generated data, thus more efficient resource usage, and a continuous representation of motion allowing lag-free tracking. Our event-based SLAM algorithm is highly efficient and runs 20 times faster than realtime, provides localization updates at several hundred Hertz, and produces excellent results. We compare our method against ground truth from an external tracking system and two state-of-the-art algorithms on a new dataset which we release in combination with this paper.
CCAAT displacement protein/ <i>cut</i> homolog recruits G9a histone lysine methyltransferase to repress transcription (2004)

CCAAT displacement protein/cut homolog (CDP/cut) is a highly conserved homeodomain protein that contains three cut repeat sequences. CDP/cut is a transcriptional factor for many diverse cellular and viral genes that are involved in most cellular processes, including differentiation, development, and proliferation. Here, we report that CDP/cut interacts with a histone lysine methyltransferase (HKMT), G9a, in vivo and in vitro. The deletion of the cut repeats within CDP/cut abrogates the interaction with G9a. The transcriptional repressor function of CDP/cut is mediated through HKMT activity of G9a associated with CDP/cut. We show that the recruitment of G9a to the human p21(waf1/cdi1) promoter is contingent on the interaction with CDP/cut, and CDP/cut is directly associated with an increase in the methylation in vivo of Lys-9 in histone H3 within the CDP/cut-regulatory region of the p21(waf1/cdi1) promoter. The endogenous level of p21(waf1/cdi1) expression is repressed through CDP/cut and mediated by HKMT activity of G9a. Furthermore, we report the identification of G9a as a component of CDP/cut complex. G9a colocalizes with CDP/cut in the nucleus. These results indicate that G9a functions as a transcriptional corepressor in association with a CDP/cut complex. These studies now reveal the interaction of G9a with a sequence-specific transcription factor that regulates gene repression through CDP/cut.
Aerial Photography Specifications for Himalayan Forest with Special Reference to Jammu and Kashmir (1971)

Nature of topography, composition and distribution of forests, objectives of photo interpretation and scale of the forest maps to be prepared are some of the important considerations for determining the scale of photography, camera and focal length of the lens to be used and season of photography. For coniferous forests of Himalayas a scale of 1:25,000 to 1:30,000 for aerial photography is suggested. Scale larger than this may not be practicable for large area survey due to mountaineous nature of the terrain. The suitable season for aerial photography appears to be October-November.
Ultra-Wideband Antenna and Design (2012)

Ultra-wideband (UWB) antennas are gaining prominence and becoming very attractive in modern and future wireless communication systems, mainly due to two factors. Firstly, people increasingly high demand for the wireless transmission rate and UWB properties such as high data rate, low power consumption and low cost, which give a huge boost to the UWB antennas’ research and development in industry and academia since the Federal Communications Commission (FCC) officially released the regulation for UWB technology in 2002. Secondly, now the wireless portable device need antenna operated in different frequencies for various wireless transmission functions, and operation bands and functions are increasing more and more, which may result in challenges in antenna design, such as antenna space limitation, multi antennas interference, and etc. One UWB antenna can be used to replace multi narrow-band antennas, which may effectively reduce the antenna number.
i-PP/HDPE blends. III. Characterization and compatibilization at loweri-PP contents (1996)

The mechanical properties of high-density polyethylene (HDPE)-rich i-PP/HDPE blends were studied. Two grades of HDPE were investigated, one with a melt viscosity close to that of the polypropylene (PP) and the other having a much lower melt viscosity. Compatibilization of the 10/90 i-PP/HDPE blend with three copolymers (an ethylene/propylene/diene [EPDM] copolymer and two ethylene/vinylacetate [EVA] copolymers, differing in their VA content) was also investigated. Blends of PP with the low melt viscosity HDPE displayed poor mechanical properties. It was not possible to improve these properties sufficiently with EPDM or EVA. In the case where viscosity matching was achieved between PP and HDPE, addition of i-PP (up to 30%) to HDPE resulted in a large drop in the impact strength of the blends, compared to that of the neat HDPE. A large drop (>50%) was also observed in the ultimate tensile elongation. However, the flexural modulus, yield stress, and ultimate tensile strength all increased with the introduction of i-PP into HDPE. Modification of these blends with an EPDM resulted in the return of all properties to values very close to those of the neat HDPE. The ultimate tensile elongation of the EPDM-modified i-PP/HDPE blend even exceeded that of the virgin HDPE. It was also found that although EVAs can be used to compatibilize these blends these additives were not as effective as was the EPDM. © 1996 John Wiley & Sons, Inc.
FAILURE OF 48 HOURS OF COLD STORAGE OF CANINE KIDNEYS USING SACKSʼ SOLUTION (1975)

Department of Surgery University of Southern California School of Medicine and Los Angeles County-USC Medical Center Los Angeles, California 90033
A preliminary study on interruption of HBV transmission in uterus. (1997)

Our study suggests that HBV infection in the uterus may be interrupted using multiple HBIG intramuscularly before delivery without any side effects.
A multi-level reconfiguration control for holonic PLC (2002)

The system architecture for a holonic PLC (HPLC) is presented and the multi-level reconfiguration control mechanism for a function block (FB)-based PLC is detailed. Based on IEC-1499 FB model concepts, the concurrent process mechanism for FB configuration control and FB process control is put forward. In the presented approach, the dynamic reconfiguration control of the HPLC is handled at three control levels: function, component, and task control. Separating configuration control at the component level from task level facilitates a code-based component maintenance and task state transition process. It can carry out on-the-fly control for the HPLC by means of task level operation and smooth state transition cooperating with associated class maintenance under the limited capability of object oriented class dynamic configuration.
<scp>l</scp> -Threonine Export: Use of Peptides To Identify a New Translocator from <i>Corynebacterium glutamicum</i> (2001)

Bacterial mechanisms for the uptake of peptides and their hydrolysis to amino acids are known in great detail, whereas much less is known about the fates of the peptide-derived amino acids. We show that the addition of L-threonine-containing di- or tripeptides results in reduction of the growth of Corynebacterium glutamicum, with concomitant high intracellular accumulation of L-threonine to up to 130 mM. Using transposon mutagenesis and isolation of mutants with increased Thr peptide sensitivity, nine open reading frames (ORFs) were identified, almost all encoding hypothetical proteins of unknown function. Three ORFs encode membrane proteins. Their individual functional characterizations in the wild-type background led to the identification of thrE. Upon thrE overexpression, growth is no longer sensitive to the presence of the Thr peptide, and L-threonine is exported at a rate of 3.8 nmol min(-1) mg of dry weight(-1), whereas the rate of export of a thrE inactivation mutant is reduced to 1.1 nmol min(-1) mg of dry weight(-1). In addition to L-threonine, L-serine is also a substrate for the exporter. The exporter exhibits nine predicted transmembrane-spanning helices with long charged C and N termini and with an amphipathic helix present within the N terminus. All these data suggest that the carrier encoded by thrE serves to export small molecules such as L-threonine and that the carrier is a prototype of a new translocator family. Homologues of ThrE are present in Mycobacterium tuberculosis and Streptomyces coelicolor.
Rapid in vitro metabolic screen for antileprosy compounds (1987)

Measurement of intracellular ATP of Mycobacterium leprae after direct in vitro exposure to antimicrobial agents was evaluated as a rapid means of identifying potentially useful therapeutic agents. Nude mouse-derived M. leprae was incubated in an axenic modified Dubos medium in the presence or absence of antimicrobial agents for up to 3 weeks. ATP was then assayed by using the firefly bioluminescence technique. Rifampin, clofazimine, and ethionamide each effected a significantly accelerated rate of ATP decay compared with controls. Dapsone appeared inactive, possibly reflecting a general insensitivity of this system to compounds acting at certain loci. The system appeared suitable for assessing comparative activity of new structural analogs of clofazimine. Other active compounds included erythromycin, minocycline, chloramphenicol, gramicidin, and, to a lesser extent, cycloserine, cephalothin, ciprofloxacin, tetracycline, and gramicidin S. The penicillins, bacitracin, isoniazid, nalidixic acid, trimethoprim, polymyxin B, and griseofulvin were all inactive. The system appears sensitive to agents with various modes of action and may prove useful as a primary screen for antileprosy drugs.
Stereochemistry of formation of methyl and ethyl groups in bacteriochlorophyll a (1981)

δ-Aminolaevulinic acid has been synthesised carrying 2H and 3H isotopes at C-2 in the S-configuration; this has been incorporated by Rhodopseudomonas spheroides into bacteriochlorophyll a, degradation of which has established the mode of addition of hydrogen to the precursor vinyl group to form the ring-B ethyl group and that the decarboxylation to form the ring-B methyl group occurs with retention.
Calcium regulating hormones and bone metabolism : basic and clinical aspects, vol. 11 : proceedings of the 11th International Conference on Calcium Regulating Hormones, Florence, 24-29 April 1992 (1992)

Eli Lilly special scientific lecture (1 paper). Calciotropic hormones: Their genes, synthesis and metabolism (10 papers). Calciotropic hormones: Receptors and action (10 papers). Bone cell biology: Osteoclasts (9 papers). Bone cell biology: Osteoblasts (10 papers). Local factors and bone metabolism (10 papers). Bone, cartilage and connective tissues matrix (10 papers). Osteoporosis (8 papers). Metabolic bone diseases and disorders of mineral metabolism (9 papers). Index of authors. Subject index.