gebhart/patrepeval huggingface dataset:
Understanding COVID-19 (2020)

The SARS-CoV-2 outbreak has changed the lives of many. To combat the disease referred to as COVID- 19, anesthesia providers must be educated on specific topics. Understanding of a brief history of previous strands of the disease details the need for measures to reduce healthcare providers exposure. As patients present to the operating room (OR), viral and antibody testing combined provides identification and prognosis of the disease with infected patients who can transmit the disease. Anesthesia providers encounter transmission entry points frequently increasing possibility of exposure. The disease process of COVID-19 can lead to progression of complications necessitating interventions from anesthesia providers. Specific care instructions can limit the possibility of provider exposure. The extensive viral plume that is produced by tracheostomy procedures amplify the probability of exposure. lf tracheostomy is in the best interest of the patient, the use the acronym CORONA for guidance of care and the use of a designated team in the OR should be utilized to reduce exposure.
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients (2013)

Early provision of glutamine or antioxidants did not improve clinical outcomes, and glutamine was associated with an increase in mortality among critically ill patients with multiorgan failure. (Funded by the Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT00133978.).
Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal (2003)

Arginase is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea. The X-ray crystal structure of a fully active, truncated form of human arginase II complexed with a boronic acid transition state analogue inhibitor has been determined at 2.7 A resolution. This structure is consistent with the hydrolysis of l-arginine through a metal-activated hydroxide mechanism. Given that human arginase II appears to play a role in regulating l-arginine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, the inhibition of human arginase II is a potential new strategy for the treatment of erectile dysfunction [Kim, N. N., Cox, J. D., Baggio, R. F., Emig, F. A., Mistry, S., Harper, S. L., Speicher, D. W., Morris, S. M., Ash, D. E., Traish, A. M., and Christianson, D. W. (2001) Biochemistry 40, 2678-2688]. Since NO synthase is found in human clitoral corpus cavernosum and vagina, we hypothesized that human arginase II is similarly present in these tissues and functions to regulate l-arginine bioavailability to NO synthase. Accordingly, hemodynamic studies conducted with a boronic acid arginase inhibitor in vivo are summarized, suggesting that the extrahepatic arginase plays a role in both male and female sexual arousal. Therefore, arginase II is a potential target for the treatment of male and female sexual arousal disorders.
Optical image encryption technique based on deterministic phase masks (2016)

The double-random phase encoding (DRPE) scheme, which is based on a 4f optical correlator system, is considered as a reference for the optical encryption field. We propose a modification of the classical DRPE scheme based on the use of a class of structured phase masks, the deterministic phase masks. In particular, we propose to conduct the encryption process by using two deterministic phase masks, which are built from linear combinations of several subkeys. For the decryption step, the input image is retrieved by using the complex conjugate of the deterministic phase masks, which were set in the encryption process. This concept of structured masks gives rise to encryption–decryption keys which are smaller and more compact than those required in the classical DRPE. In addition, we show that our method significantly improves the tolerance of the DRPE method to shifts of the decrypting phase mask—when no shift is applied, it provides similar performance to the DRPE scheme in terms of encryption–decryption results. This enhanced tolerance to the shift, which is proven by providing numerical simulation results for grayscale and binary images, may relax the rigidity of an encryption–decryption experimental implementation setup. To evaluate the effectiveness of the described method, the mean-square-error and the peak signal-to-noise ratio between the input images and the recovered images are calculated. Different studies based on simulated data are also provided to highlight the suitability and robustness of the method when applied to the image encryption–decryption processes.
Female choice in the red mason bee,<i>Osmia rufa</i>(L.) (Megachilidae) (2010)

Females are often thought to use several cues and more than one modality in selection of a mate, possibly because they offer complementary information on a mate's suitability. In the red mason bee, Osmia rufa, we investigated the criteria a female uses to choose a mating partner. We hypothesized that the female uses male thorax vibrations and size as signs of male viability and male odor for kin discrimination and assessment of genetic relatedness. We therefore compared males that had been accepted by a female for copulation with those rejected, in terms of their size, their immediate precopulatory vibrations (using laser vibrometry), the genetic relatedness of unmated and mated pairs (using microsatellite markers) and emitted volatiles (using chemical analyses). Females showed a preference for intermediate-sized males that were slightly larger than the modal male size. Furthermore, male precopulatory vibration burst duration was significantly longer in males accepted for copulation compared with rejected males. Vibrations may indicate vigor and assure that males selected by females are metabolically active and healthy. Females preferentially copulated with males that were genetically more closely related, possibly to avoid outbreeding depression. Volatiles of the cuticular surface differed significantly between accepted and rejected males in the relative amounts of certain hydrocarbons, although the relationship between male odor and female preference was complex. Females may therefore also use differences in odor bouquet to select among males. Our investigations show that O. rufa females appear to use multiple cues in selecting a male. Future investigations are needed to demonstrate whether odor plays a role in kin recognition and how the multiple cues are integrated in mate choice by females.
Accelerating Transform Algorithm Implementation for Efficient Intra Coding of 8K UHD Videos (2022)

Real-time ultra-high-definition (UHD) video applications have attracted much attention, where the encoder side urgently demands the high-throughput two-dimensional (2D) transform hardware implementation for the latest video coding standards. This article proposes an effective acceleration method for transform algorithm in UHD intra coding based on the third generation of audio video coding standard (AVS3). First, by conducting detailed statistical analysis, we devise an efficient hardware-friendly transform algorithm that can reduce running cycles and resource consumption remarkably. Second, to implement multiplierless computation for saving resources and power, a series of shift-and-add unit (SAU) hardwares are investigated to have much less adoptions of shifters and adders than the existing methods. Third, different types of hardware acceleration methods, including calculation pipelining, logical-loop unrolling, and module-level parallelism, are designed to efficaciously support the data-intensive high frame-rate 8K UHD video coding. Finally, due to the scarcity of 8K video sources, we also provide a new dataset for the performance verification. Experimental results demonstrate that our proposed method can effectively fulfill the real-time 8K intra encoding at beyond 60 fps, with very negligible loss on rate-distortion (R-D) performance, which is averagely 0.98% Bjontegaard-Delta Bit-Rate (BD-BR).
Ion beam sputter etching and deposition of fluoropolymers (1978)

Fluoropolymer etching and deposition techniques including thermal evaporation, RF sputtering, plasma polymerization, and ion beam sputtering are reviewed. Etching and deposition mechanism and material characteristics are discussed. Ion beam sputter etch rates for polytetrafluoroethylene (PTFE) were determined as a function of ion energy, current density and ion beam power density. Peel strengths were measured for epoxy bonds to various ion beam sputtered fluoropolymers. Coefficients of static and dynamic friction were measured for fluoropolymers deposited from ion bombarded PTFE.
Hypoxia-Inducible Factor-1 α Expression Predicts Superior Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP (2010)

PURPOSE Hypoxia-inducible factor (HIF) controls the expression of genes in response to hypoxia, as well as a wide range of other cellular processes. We previously showed constitutive stabilization of HIF-1alpha in the majority of patients with diffuse large B-cell lymphoma (DLBCL). To our knowledge, the prognostic significance of HIF in lymphoma has never been investigated. PATIENTS AND METHODS We studied the immunohistochemical protein expression of HIF-1alpha on tissue microarrays from 153 patients with DLBCL treated in sequential cohorts with cyclophosphamide, doxorubicin, oncovin, and prednisone (CHOP) or rituximab-CHOP (R-CHOP) from 1999 to 2002. Results were correlated with patient outcome. Results Median follow-up for all patients was 80 months. Among all patients, HIF-1alpha was expressed in 62% of germinal center and 59% of non-germinal center patients. With HIF-1alpha analyzed as a dependent variable, there were no survival differences in CHOP-treated patients. In the R-CHOP group, however, HIF-1alpha protein expression correlated with significantly improved progression-free survival (PFS) and overall survival (OS). Five-year PFS for HIF-1alpha-positive patients was 71% v 43% for HIF-1alpha-negative patients (P = .0187), whereas 5-year OS was 75% and 54%, respectively (P = .025). In multivariate analysis with International Prognostic Index criteria, HIF-1alpha remained a significant predictor for PFS (P = .026) and OS (P = .043). Compared with other biomarkers, HIF-1alpha correlated only with BCL6 (P = .004). In terms of gene expression, we found several common gene associations of HIF-1alpha and the stromal-1 signature with genes predominantly involved in regulation of the extracellular matrix (eg, BGN, COL1A2, COL5A1, and PLOD2). CONCLUSION The expression of HIF-1alpha protein is an important independent favorable prognostic factor for survival in patients with DLBCL treated with R-CHOP.
Efficient 2.5-D true-amplitude migration (2000)

Abstract Kirchhoff depth migration is a widely used algorithm for imaging seismic data in both two and three dimensions. To perform the summation at the heart of the algorithm, standard Kirchhoff migration requires a traveltime map for each source and receiver. True-amplitude Kirchhoff migration in 2.5-D v(x,z) media additionally requires maps of amplitudes, out-of-plane spreading factors, and takeoff angles; these quantities are necessary for calculating the true-amplitude weight term in the summation. The increased input/output (I/O) and computational expense of including the true-amplitude weight term is often not justified by significant improvement in the final muted and stacked image. For this reason, some authors advocate neglecting the weight term in the Kirchhoff summation entirely for most everyday imaging purposes. We demonstrate that for nearly the same expense as ignoring the weight term, a much better solution is possible. We first approximate the true-amplitude weight term by the weight term for constant-velocity media; this eliminates the need for additional source and receiver maps. With one small additional approximation, the weight term can then be moved entirely outside the innermost loop of the summation. The resulting Kirchhoff method produces images that are almost as good as for exact true-amplitude Kirchhoff migration and at almost the same cost as standard methods that do not attempt to preserve amplitudes.
An Experimental Study of a Lithium Ion Cell Operation at Low Temperature Conditions (2017)

Lithium-ion (Li-ion) batteries are widely used for various applications such as telecommunication, automotive, and stationary applications. With their wide range of safe operating temperatures (i.e. -10 °C to 50 °C), the Li-ion is preferred over other types of matured battery technologies such as lead acid and nickel-cadmium (NiCd). Nevertheless, operating the Li-ion batteries at cold climate conditions can potentially harm the batteries and lead to issues such as degradation and reduction in their capacity and power density. This paper aims to experimentally investigate the behavior of a Li-ion cell operating at low temperatures (i.e. -15 °C to 25 °C) with respect to its charging and discharging behavior. It was observed that at sub-zero temperatures (i.e. -5 °C, -10 °C and -15 °C) the Li-ion cell's capacity is reduced due to the impedance effect which then increases the cell's internal resistance. Moreover, at such low temperatures the best state of charge (SOC) of the cell (i.e. during charging mode) has reduced to about 7-23% of its maximum initial SOC (i.e. 100%). To complement the experimental finding, an existing simplified adaptive thermal model was used to obtain the discharge curves at various current rates based on the function of extracted charge (Qout). The discharge curve of equilibrium potential (Eeq) is then extrapolated towards zero current in order to obtained the overpotential heat generation curve based on the discharge current of the cell. The result showed a good agreement to the discharge curves that were obtained experimentally. Likewise, with the finding of cell voltage (E), current (I) and temperature (T) that were obtained experimentally, the thermal behavior of the cell in respect of its internal temperature is predicted and represented by comparing both the simulated and experimental cell internal temperatures.
Melatonin stimulates inositol‐1,4,5‐trisphosphate and Ca<sup>2+</sup>release from INS1 insulinoma cells (2005)

The effects of melatonin in mammalian cells are exerted via specific receptors or are related to its free radical scavenging activity. It has previously been reported that melatonin inhibits insulin secretion in the pancreatic islets of the rat and in rat insulinoma INS1 cells via Gi-protein-coupled MT1 receptors and the cyclic adenosine 3',5'-monophosphate pathway. However, the inositol-1,4,5-trisphosphate (IP3) pathway is involved in the insulin secretory response as well, and the melatonin signal may play a part in its regulation. This paper addresses the involvement of the second messengers IP3 and intracellular Ca2+ ([Ca2+]i) in the signalling cascade of melatonin in the rat insulinoma INS1 cell, a model for the pancreatic beta-cell. For this purpose melatonin at concentrations ranging from 1 to 100 nmol/L, carbachol and the nonselective melatonin receptor antagonist luzindole were used to stimulate INS1 cell batches, followed by an IP3-mass assay and Ca2+ imaging. Molecular biological studies relating to the mRNA of IP3 receptor (IP3R) subtypes and their relative abundance in INS1 cells showed expression of IP3R-1, IP3R-2 and IP3R-3 mRNA. In conclusion, we found that in rat insulinoma INS1 cells there is a dose-dependent stimulation of IP3 release by melatonin, which is accompanied by a likewise transient increase in [Ca2+]i concentrations. The melatonin effect observed mimics carbachol action. It can be abolished by 30 micromol/L luzindole and is sustained in Ca2+-free medium, suggesting a mechanism that includes the depletion of Ca2+ from intracellular stores.
The Deoxyribonucleic Acid Modification and Restriction Enzymes of Escherichia coli B (1972)

The modification methylase of Escherichia coli B has been purified to apparent homogeneity. The enzyme can exist in several forms, each possessing two nonidentical polypeptides, β and γ, of molecular weights of 60,000 and 55,000, respectively. Freshly isolated enzyme has the structure β1γ1, but upon storage at neutral pH and low salt, it disproportionates, producing another form, β3γ1. Treatment at pH 5 converts the mixture of β3γ1 and β1γ1 to a mixture of β1γ1 and another form β2γ1, whereas exposure to high salt breaks down the β3γ1 structure. The enzyme is inhibited by S-adenosylethionine and 5′-methylthioadenosine, but not by S-adenosylhomocysteine. None of these compounds can replace the required cofactor, S-adenosylmethionine. The enzyme can methylate a wide variety of DNAs, but not DNA produced by E. coli B.
High prevalence of SARS-CoV-2 swab positivity and increasing R number in England during October 2020: REACT-1 round 6 interim report (2020)

Abstract Background REACT-1 measures prevalence of SARS-CoV-2 infection in representative samples of the population in England using PCR testing from self-administered nose and throat swabs. Here we report interim results for round 6 of observations for swabs collected from the 16th to 25th October 2020 inclusive. Methods REACT-1 round 6 aims to collect data and swab results from 160,000 people aged 5 and above. Here we report results from the first 86,000 individuals. We estimate prevalence of PCR-confirmed SARS-CoV-2 infection, reproduction numbers (R) and temporal trends using exponential growth or decay models. Prevalence estimates are presented both unweighted and weighted to be representative of the population of England, accounting for response rate, region, deprivation and ethnicity. We compare these interim results with data from round 5, based on swabs collected from 18th September to 5th October 2020 inclusive. Results Overall prevalence of infection in the community in England was 1.28% or 128 people per 10,000, up from 60 per 10,000 in the previous round. Infections were doubling every 9.0 (6.1, 18) days with a national reproduction number (R) estimated at 1.56 (1.27, 1.88) compared to 1.16 (1.05, 1.27) in the previous round. Prevalence of infection was highest in Yorkshire and The Humber at 2.72% (2.12%, 3.50%), up from 0.84% (0.60%, 1.17%), and the North West at 2.27% (1.90%, 2.72%), up from 1.21% (1.01%, 1.46%), and lowest in South East at 0.55% (0.45%, 0.68%), up from 0.29% (0.23%, 0.37%). Clustering of cases was more prevalent in Lancashire, Manchester, Liverpool and West Yorkshire, West Midlands and East Midlands. Interim estimates of R were above 2 in the South East, East of England, London and South West, but with wide confidence intervals. Nationally, prevalence increased across all age groups with the greatest increase in those aged 55-64 at 1.20% (0.99%, 1.46%), up 3-fold from 0.37% (0.30%, 0.46%). In those aged over 65, prevalence was 0.81% (0.58%, 0.96%) up 2-fold from 0.35% (0.28%, 0.43%). Prevalence remained highest in 18 to 24-year olds at 2.25% (1.47%, 3.42%). Conclusion The co-occurrence of high prevalence and rapid growth means that the second wave of the epidemic in England has now reached a critical stage. Whether via regional or national measures, it is now time-critical to control the virus and turn R below one if further hospital admissions and deaths from COVID-19 are to be avoided.
Impact of Reducing STI-Induced Stress on Layout Dependence of MOSFET Characteristics (2004)

Active-area layout dependence of MOSFET parametric characteristics and its reduction by reducing shallow trench isolation (STI)-induced mechanical stress were investigated. Threshold voltages (V/sub th/) and saturation drain currents (I/sub ds/) become sensitive to the active-area layout of MOSFET in scaled-down technology. This phenomenon is the effect of mechanical stress from STI edge, which reduces impurity diffusion in channel region and enhances carrier mobility. To reduce the STI-induced stress, we examined STI-wall-oxide nitridation and STI gap-fill-oxide densifying in pure N/sub 2/ ambient. These processes reduced the reoxidation of the STI wall oxide, therefore reduced the STI-induced stress. According to the new STI process, the active-area layout dependence of V/sub th/ and I/sub ds/ were reduced successfully.
Real-time detection of moving objects from moving vehicles using dense stereo and optical flow (2005)

Dynamic scene perception is very important for autonomous vehicles operating around other moving vehicles and humans. Most work on real-time camera based object tracking from moving platforms has used sparse features or assumed flat scene structures. We have recently extended a real-time, dense stereo system to include real-time, dense optical flow, enabling more comprehensive dynamic scene analysis. We describe algorithms to robustly estimate 6-DOF robot egomotion in the presence of moving objects using dense flow and dense stereo. We then use dense stereo and egomotion estimates to identify other moving objects while the robot itself is moving. We present results showing accurate egomotion estimation and detection of moving people and vehicles under general 6-DOF motion of the robot and independently moving objects. The system runs at 18.3 Hz on a 1.4 GHz Pentium M laptop, computing 160/spl times/120 disparity maps and optical flow fields, egomotion, and moving object segmentation. We believe this is a significant step toward general unconstrained dynamic scene analysis for mobile robots, as well as for improved position estimation where GPS is unavailable.
The effect of starvation on the rate of protein synthesis in rat liver and small intestine (1979)

1. A method is described that allows for measurement of protein synthesis in liver and intestine in the rat. By injecting a massive amount of [14C]leucine (100 mumol/100 g body wt.) an attempt has been made to over come problems of precursor specific radioactivity and problems arising from the breakdown of labelled protein that are encountered when tracer amounts of amino acids are used. 2. Starvation for 2 days resulted in decline in the rate of total liver protein synthesis from 87%/day to 62%/day. 3. In jejunal mucosa the rate of protein synthesis was 136%/day. This declined to 105%/day after 2 days of starvation.
BICYCLOHEPTADIENE DIBROMIDES (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBICYCLOHEPTADIENE DIBROMIDESS. WinsteinCite this: J. Am. Chem. Soc. 1961, 83, 6, 1516–1517Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/ja01467a058https://doi.org/10.1021/ja01467a058research-articleACS PublicationsRequest reuse permissionsArticle Views1712Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts