gebhart/patrepeval huggingface dataset:
Food and allergy. (1995)

Food allergy is perhaps the most controversial area of clinical immunology. The literature is filled with anecdotal reports. Food allergy refers to an untoward immune-mediated reaction caused by ingestion of food antigens. It should be distinguished from non-immunological adverse reactions to food since their therapeutic and prognostic implications are different. This review article examines some of the important issues with regards to the pathogenesis, symptomatology, diagnosis and treatment of food allergy.
Pulmonary Hypertension in Chronic Renal Failure Patients (2008)

Results show a high prevalence of PHT among patients with ESRD on chronic HD or on conservative treatment. PHT in such patients is related to AVF flow, TXB(2) and NT-proBNP level and LVDD. AVF flow is an important correctable cause of PHT.
Scoliosis in Pediatric Spinal Cord-Injured Patients (1990)

One hundred thirty children who sustained spinal cord injuries between birth and age 21 years were reviewed to determine the progression rate of paralytic scoliosis and the effects of bracing and surgery. Patients were divided into two groups: those injured before and those injured after the adolescent growth spurt. Scoliosis developed in 97 and 52%, respectively. Bracing was effective in delaying progression in the preadolescent group. The progressive paralytic spinal deformity did not appear to be related to the level of injury. The older patient is at much less risk for paralytic scoliosis, but still requires routine examination.
Development of Replication-Defective Herpes Simplex Virus Vectors (2003)

Numerous diseases of the nervous system result from single gene or multifactorial gene defects such as cancer, immune pathological disorders, metabolic diseases, and common neurodegenerative syndromes (Parkinson's and Alzheimer's diseases). A greater understanding of the molecular, biochemical, and genetic factors involved in the progression of a specific disease state has led to the development of genetic therapies using direct gene transfer to ameliorate the disease condition or correct a genetic defect in situ. Standard gene therapeutic approaches employing retroviruses have not proven feasible for treating disorders of the central nervous system (CNS) since these vectors require dividing cells for integration and expression of the transgene, whereas CNS neurons are postmitotic, terminally differentiated cells. Thus, methods for delivery and expression of therapeutic gene products to treat CNS disease will require new delivery strategies and vehicles including the development of novel vectors for direct gene transfer. These vectors should: efficiently deliver the therapeutic gene(s) to a sufficient number of nondividing neurons; persist long-term in a nonintegrated state within the nerve cell nucleus without disturbing host cell functions; and be able to regulate therapeutic gene expression for diseases that may either require high-level transient transgene expression or continuous low level synthesis of the therapeutic product.
Quantitative aspects on mitochondrial monoamine oxidase in human platelets. (1976)

The number of monoamine oxidase molecules in human blood platelets has been estimated by titrating them with the irreversible monoamine oxidase inhibitor pargyline to be about 900 per thrombocyte and 200--300 per thrombocyte mitochondrion. It has also been calculated that monamine oxidase constitutes about 1/5,000 of the platelet mitochondrial outer membrane surface. Molecular turnover numbers for benzylamine and tyramine have been estimated to be about 1,470 and 720, respectively.
Study of the Drug Diffusion Through Polymeric Membranes (2018)

We present the studies carried out on the transport properties of some membranes obtained from synthetic polymers: polyurethane and ethylene-vinyl acetate copolymer, for use in the development of transdermal therapeutic systems with limiting membranes of speed. The properties of drug active substances transport through membranes were highlighted by performing studies with a diffusion cell. Experimental drug active substances were paracetamol and tetracycline. The experimental data obtained was processed using a general mathematical model for drug release from non-porous, non-swellable transdermal devices, which starts from Fick�s second law and has terms that also take into account the possibility of retaining the drug in the membrane polymer. Even though the mathematical model does not take into account neither the swelling phenomenon nor the possibility of membrane erosion, a good agreement between model and experimental data was obtained. The values of effective diffusion coefficients of drug in the polymeric membranes were also determined.
Principles and practice of plant conservation (1995)

Principles and Practice of Plant Conservation is the first exhaustive and systematic treatment of the issues of plant conservation, other books on the subject having been collections of articles on specialized topics or of a regional nature. This book, growing out of a major sponsorship effort by two of the world's leading conservation organizations to 'assert the fundamental importance of plants in all conservation activities', provides the well-integrated coverage that arises from an expert's thoughtful analysis of the entire subject. Commissioned by the World Wide Fund for Nature and IUCN - The World Conservation Union as part of their joint endeavor of 'building the capacity to conserve', this work by David R. Given elucidates the concepts that underlie successful conservation efforts. Drawing on his own work and involving international collaboration, the author also presents a large number of real-life case studies that illustrate the principles of conservation in action. Chapters are devoted to the natural - and unnatural - causes of plant rarity and endangerment, and the management of plant populations in natural habitats, in modified landscapes, and off-site to preserve germplasm. Going beyond the biology of conservation, other chapters are devoted to the ethical, educational, and economic aspects of plant conservation. Cyrille de Klemm, an expert on international law, has contributed a chapter on conservation legislation. Plants play critical roles in the web of life, providing the food and shelter on which animals depend. As human population and development pressures on the world's biota increase, it is in the best interest of all to use plant resources wisely and sustainably.That will be possible only if plant diversity is maintained, and Principles and Practice of Plant Conservation is an essential reference for those concerned with how best to preserve what we have.
Protocol standard for a NetBIOS service on a TCP/UDP transport: Concepts and methods (1987)

This RFC defines a proposed standard protocol to support NetBIOS
services in a TCP/IP environment. Both local network and internet
operation are supported. Various node types are defined to accommodate
local and internet topologies and to allow operation with or without
the use of IP broadcast. This RFC describes the NetBIOS-over-TCP
protocols in a general manner, emphasizing the underlying ideas and
techniques. Detailed specifications are found in a companion RFC,
Protocol Standard For a NetBIOS Service on a TCP/UDP Transport:
Detailed Specifications.
Hippocampal Aging and Adrenocorticoids: Quantitative Correlations (1978)

Altered neural-endocrine relations have been proposed as factors in mammalian aging. In the same rats from three age groups we quantified astrocyte reactivity in hippocampus, performed radioimmunoassays for plasma adrenocorticoids, and measured adrenal weight. These variables were correlated in individual animals and generally increased with age. The findings are consistent with recent hypotheses that endocrine levels are related to brain aging, either as cause or effect.
Behavioral genetics of thermosensation and hygrosensation in Drosophila. (1996)

Whereas temperature and humidity are critical variables affecting physiology, behavior, and evolution, the genetic and neuronal underpinnings of thermosensation and hygrosensation remain poorly understood. We have initiated a behavioral-genetic investigation of these sensory systems in Drosophila. Behavioral tests are described for the rapid screening of mutants defective in thermosensation and hygrosensation. We demonstrate the strong responses of normal flies to temperature and humidity. Two mutants were found with defects in thermosensation, only one of which is also defective in hygrosensation, indicating that they involve different sensory mechanisms. Ablation experiments further separate these sensory systems by showing that thermoreceptors are housed in the third antennal segment, whereas hygroreceptors are located more distally in the antennal arista.
Unifying past and recent developments in bounded ellipsoid processing (2002)

A general class of optimal bounding ellipsoid (OBE) algorithms, including all methods published to date, is unified into a single framework called the unified OBE (UOBE) algorithm. Different instances of UOBE are distinguished by their weighting policies and the criteria for determining optimal weight values. Two new UOBE techniques are introduced within the UOBE framework.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Venous leg ulcer]. (1997)

The article summarizes current views regarding venous leg ulcers. Venous ulcers are resource-demanding and affect 1% of the population. Superficial and/or deep venous insufficiency is to be found combined with perforator insufficiency in the ankle are. The pathogenesis is still open to debate, but is presumably related to capillary leakage, with seepage of blood components and ensuing lipodermatosclerosis, as well as to multiple capillary thromboses. Inappropriate leucocyte activation might also play a part. Compression stabilizes capillary function and thus is the cardinal treatment both regarding healing and prophylaxis. In 90% of cases there is no recurrence following superficial vein surgery, so long as the deep veins remain unaffected. In patients with deep venous insufficiency the risk of failure following-such surgery, perforator resection included, is related to the degree of insufficiency. If conventional treatment fails, reconstruction of the deep veins may be considered. Concomitant conditions such as arterial insufficiency and systemic diseases make treatment difficult, and the presence of Pseudomonas aeruginosa may in certain cases delay healing.
Problems of stone mastic asphalt use in north Queensland (2006)

Stone Mastic Asphalt (SMA) is widely used throughout the world as one of the\npreferred asphalt surfacings. The history of use of this material dates back some 30\nyears ago, and like every product stone mastic asphalt needs to be modified and adapted\nto conform modern materials and manufacture, as well as suit the various local\nconditions. This dissertation develops and analyses the variances in all properties of\nSMA within a tropical climate. The aim is to provide background information into the\nhistory of the product and the current best practice, before moving into the\nspecifications and requirements of the North Queensland region. The methodology will\ntake the format of the testing of trial sections, analysing data and results, compiling\ndetails and collating information within the prioritized sections. The aim is to make\ndefinite correlations between specific criteria and then hypothesis on the possibilities.\nThe outcome is the actual design criteria that leads to particular properties and arrive at\nthe failure mechanisms of stone mastic asphalt. The applicability of this paper will be a\ndocument which aligns with the Government Standards for Asphalt design to either\nreinforce or alter current practices.\nThe impacts of filler and binder components of the mastic are assessed on the\nperformance of SMA. The paper develops a design method to ensure that the important\nfeatures of the coarse aggregate stone skeleton are attained, providing a rut resistant\nlong life asphalt. Analysis is provides in the combining of criteria on rut resistance and\nfatigue performance to arrive at a mix design shows good strength, texture and stability\nfor use in surfacing works with heavy traffic condition. Elastic and fatigue properties\nare assessed by analyzing the affects of fillers, binders and temperature and the\nrelationship between stiffness and fatigue.\nSMA is an unforgiving mix and requires changes and modifications to the mix design to\nenhance the characteristics of its performance. This is evident through the varying\nspecifications across the State, and the North Queensland developments form a major\ntopic within the report. Whilst SMA a premium asphalt product it is not a panacea for\nall pavement situations. Its use and specification requires exercising sound engineering\njudgment. This research will provide a rational basis for such judgment.
Matrix Acidizing in Gas Wells (2000)

Abstract Matrix acidizing treatments are applied to gas wells to remove near-wellbore permeability impairment (formation damage). The acidizing process differs in gas wells compared with oil wells or water injection wells because of two-phase, gas-liquid flow during acid injection, and also because of the relatively low viscosity of the gas. This paper demonstrates how these differences affect the penetration of acid into the formation and the distribution of acid along the wellbore (acid placement). When acid displaces gas in the formation around the wellbore, the favorable mobility ratio between the acid and the gas will lead to a piston-like displacement of the gas by the acid. However, behind the acid front, a residual gas saturation will remain. Our study shows that the impact of the residual gas saturation increases acid penetration into the reservoir, when compared with a single-phase displacement process. The large contrast between the viscosity of the acid and the gas in the reservoir may be beneficial to a better distribution of acid along the wellbore. Because the acid is much more viscous than the gas, there will be an increased pressure drop wherever acid is placed in the formation. This can function as a natural viscous diversion - as acid enters the higher permeability zones, the increased pressure gradient can divert relatively more acid to lower permeability zones. We present modeling results that illustrate the magnitude of the viscous diversion effect in gas wells. This natural diversion precludes the use of gels or other viscous fluids for diversion in gas wells.
Generation of canonical forms for multiport filtering networks (2014)

We describe in this work a procedure for generating a family of canonical prototypes for multiport filtering networks, starting from the transversal canonical prototype. The coupling matrix of the forms generated is be also obtained by applying a suitable algorithm based on Matrix Rotations. Using these tools, a multiplexer synthesized with the star-junction topology can be transformed into a new form, where there are no longer n 2-port filters connected to a common port. The synthesis of a duplexer with a new topology illustrates the procedure developed.
Role of epidermal growth factor and its receptor in central nervous system injury and recovery (2013)

Central nervous system (CNS) injury is a disease with high disability in modern society, and it is widely believed for quite a long time that CNS cannot regenerate once injured. Recently, epidermal growth factor and its receptor have been reported to play an important role in both CNS injury and restoration through multiple mechanisms including inflammation response, reactive oxygen production, glial scar formation, myelinoclasis and neuron repair.
Water soluble pentacene (2013)

A water soluble pentacene, potassium 3,3′-(pentacene-6,13-diylbis(sulfanediyl))dipropanoate (4), has been synthesized and characterized. The synthesis of 4 is straightforward and scalable, and its isolation does not require time consuming chromatographic separations. UV-vis spectra in several solvents indicate an optical HOMO–LUMO gap of approximately 1.91–1.97 eV. Water soluble pentacene 4 is long-lived in the solution phase and in the solid state. Because it forms stable solutions, inks based on 4 have been formulated and printed onto paper and flexible plastic using an unmodified commercial ink-jet printer. A bi-layer photovoltaic cell using 4 as donor and [60]fullerene as acceptor was fabricated and shown to be active. The crystal structure of the pentacene diacid precursor to water soluble pentacene 4 has been solved and shows a parallel displaced arrangement of pentacene rings, indicative of stabilizing π–π stacking interactions. DFT modeling for 4, however, suggests an unusual, low energy conformation in which both potassium carboxylate moieties are located on the same face (syn) of the pentacene π system. Likewise, calculated two-molecule stacks of 4 suggest a crystal packing arrangement in which potassium carboxylate moieties are intercalated between adjacent pentacene rings.
Linear energy transfer dependence of a normoxic polymer gel dosimeter investigated using proton beam absorbed dose measurements (2004)

Three-dimensional dosimetry with good spatial resolution can be performed using polymer gel dosimetry, which has been investigated for dosimetry of different types of particles. However, there are only sparse data concerning the influence of the linear energy transfer (LET) properties of the radiation on the gel absorbed dose response. The purpose of this study was to investigate possible LET dependence for a polymer gel dosimeter using proton beam absorbed dose measurements. Polymer gel containing the antioxidant tetrakis(hydroxymethyl)phosphonium (THP) was irradiated with 133 MeV monoenergetic protons, and the gel absorbed dose response was evaluated using MRI. The LET distribution for a monoenergetic proton beam was calculated as a function of depth using the Monte Carlo code PETRA. There was a steep increase in the Monte Carlo calculated LET starting at the depth corresponding to the front edge of the Bragg peak. This increase was closely followed by a decrease in the relative detector sensitivity (Srel = Dgel/Ddiode), indicating that the response of the polymer gel detector was dependent on LET. The relative sensitivity was 0.8 at the Bragg peak, and reached its minimum value at the end of the proton range. No significant effects in the detector response were observed for LET < 4.9 keV microm(-1), thus indicating that the behaviour of the polymer gel dosimeter would not be altered for the range of LET values expected in the case of photons or electrons in a clinical range of energies.
Tracking Synchronization of Multiple 3-DOF Experimental Helicopters (2005)

In this paper, a synchronized trajectory tracking control strategy is proposed for multiple experimental three-degrees-of-freedom (3-DOF) helicopters. This model-based controller includes a feedforward dynamic term and uses a PD control law as feedback. The convergence is achieved for both trajectory tracking and the motion synchronization. A proposed generalized synchronization concept further improves the transient performance. Numerical simulation results of four helicopters in coordination are presented.
Interferon sensitive and insensitive MHC variants of a murine thymoma differentially resistant to methotrexate-containing antibody-directed liposomes and immunotoxin. (1986)

We evaluated the ability of methotrexate-containing liposomes or a ricin alpha-chain immunotoxin, both associated with monoclonal antibodies specific for the major histocompatibility complex-encoded class I molecule H-2Kk, to kill cells of the murine k haplotype thymoma RDM4. Cells were incubated with liposomes or immunotoxin in the presence or absence of interferon-gamma, which is known to augment the expression of the target class I molecules. The great majority of cells were killed by either of these reagents. Two types of mutant cells were obtained: type 1 cells, selected by methotrexate-containing liposomes, failed to express sufficient target H-2k molecules to be killed by liposomes in the absence of interferon-gamma. In the presence of interferon-gamma, these cells increased expression of all H-2 class I molecules and could be killed by targeted liposomes. Type 2 cells were immunoselected from cloned type 1 cells by liposomes in the presence of interferon. These cells failed to respond to interferon with expression of the H-2Kk molecule, but continued to augment H-2Dk expression in response to interferon. A third variant (type 3) selected from the wild type population by an H-2Kk specific immunotoxin in the absence of interferon phenotypically resembled type 1 cells. Type 1 but not type 2 cells respond to interferon by augmented synthesis of H-2Kk specific mRNA. The results suggest that for interferon-sensitive cell surface molecules of tumor cells, use of interferon improves the efficacy of targeted chemotherapy, but does not prevent development of mutants lacking the target molecule.
Den lige linje i Grundtvigs religiøse udvikling (1970)

“The Direct Line in Grundtvig’s Religious DevelopmentBy Jakob RodGrundtvig’s religious development is largely influenced by crises, sudden realisations of “crystal clear” truths and breaks with the past. But this does not imply that there is no coherence. On the contrary there is a direct line in his religious development from his childhood, through his youth, and to his mature years.The writer attempts to reveal this line by bringing to light autobiographical features from Grundtvig’s writings. Attention is focused not so much upon Grundtvig’s theological opinions as upon his emotional attitude to religion. This latter is regarded as a constituent factor not only of his religious attitude, but to a certain extent also of his opinions.The various religious crises are explained as results of a repression of emotional life in his childhood and youth. Grundtvig’s inner struggle is accordingly seen as a struggle towards a form of Christianity in which his emotional life could assert itself. His emotional demands, as they appear, even during crises, show that Grundtvig’s development, hidden behind his changing opinions, always points towards a single goal: the rebirth of the faith of his childhood in a mature form.