gebhart/patrepeval huggingface dataset:
Regulation of autolysins in teichuronic acid‐containing<i>Bacillus subtilis</i>cells (2002)

Bacillus subtilis cells grown under phosphate starvation induce teichuronic acid (TUA) synthesis while simultaneously repressing teichoic acid synthesis (TA). The turnover rates of TA-containing and TUA-containing walls are similar, indicating that autolysin function is similar and suggesting that modulation of autolytic function may be similar. In this study, it is demonstrated, utilizing fluorescein isothiocyanate (FITC)-dextran to probe the wall pH, that a low pH exists in the wall matrix. A second probe, cationized ferritin (CF), was used to observe cell surface protonation. Suspensions of B. subtilis cells containing either TA or TUA were aggregated with CF only after the addition of a proton-motive-force-dissipating agent. Respiring B. subtilis TUA-containing cells labelled with FITC-dextran exhibited little fluorescence. Conversely, fluorescence intensities exhibited by cells de-energized with nitrogen gas were significantly greater. The effects of protonmotive force on autolytic activity were studied by adding cell wall protein extract containing concentrated autolysin to exponentially growing TA-containing and TUA-containing B. subtilis cells. Both TUA-containing and TA-containing cells were lysed only after the addition of sodium azide. These data suggest that during normal growth the wall of TUA-containing B. subtilis cells is protonated, and proton-motive force influences autolytic regulation in both TUA-containing and TA-containing B. subtilis cells.
Nuclear magnetic resonance spectroscopy using flowing liquids. CIDNP [chemically induced dynamic nuclear polarization] study of the oxidation of isopropyl alcohol using titanous ion with hydrogen peroxide (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear magnetic resonance spectroscopy using flowing liquids. CIDNP [chemically induced dynamic nuclear polarization] study of the oxidation of isopropyl alcohol using titanous ion with hydrogen peroxideMichael Cocivera, Colin A. Fyfe, Shiv P. Vaish, and Holger E. ChenCite this: J. Am. Chem. Soc. 1974, 96, 5, 1611–1613Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/ja00812a065https://doi.org/10.1021/ja00812a065research-articleACS PublicationsRequest reuse permissionsArticle Views47Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improvement of Post-Exposure Delay Stability in Alicyclic ArF Excimer Photoresists (1999)

This paper reports work toward designing environmentally stable alicyclic polymer-based photoresists for ArF excimer laser lithography. A design concept for improving post-exposure delay stability is suggested in this paper. The polymers described here were prepared from dinorbornene derivatives and maleic anhydride by free radical polymerization. The relationship among polymer structure, glass transition temperature (Tg) and post-exposure delay stability was studied. This new polymer design offers a pathway towards good post-exposure delay stability while maintaining high resolution.
SLE—a disease of clearance deficiency? (2005)

Systemic lupus erythematosus (SLE) is a multifactorial disease and its pathogenesis and precise aetiology remain unknown. Under physiological conditions, neither apoptotic nor necrotic cell material is easily found in tissues because of its quick removal by a highly efficient scavenger system. Autoantigens are found in apoptotic and necrotic material and they are recognized by autoimmune sera from SLE patients. The clearance of dying cells is finely regulated by a highly redundant system of receptors on phagocytic cells and bridging molecules, which detect molecules specific for dying cells. Changes on apoptotic and necrotic cell surfaces are extremely important for their recognition and further disposal. Some SLE patients seem to have an impaired ability to clear such apoptotic material from tissues, and this could cause the breakdown of central and peripheral mechanisms of tolerance against self-antigens. In this article, we address the cells, receptors and molecules involved in the clearance process and show how deficiencies in this process may contribute to the aetiopathogenesis of SLE.
C 3 D: Mitigating the NUMA bottleneck via coherent DRAM caches (2016)

Massive datasets prevalent in scale-out, enterprise, and high-performance computing are driving a trend toward ever-larger memory capacities per node. To satisfy the memory demands and maximize performance per unit cost, today's commodity HPC and server nodes tend to feature multi-socket shared memory NUMA organizations. An important problem in these designs is the high latency of accessing memory on a remote socket that results in degraded performance in workloads with large shared data working sets. This work shows that emerging DRAM caches can help mitigate the NUMA bottleneck by filtering up to 98% of remote memory accesses. To be effective, these DRAM caches must be private to each socket to allow caching of remote memory, which comes with the challenge of ensuring coherence across multiple sockets and GBs of DRAM cache capacity. Moreover, the high access latency of DRAM caches, combined with high inter-socket communication latencies, can make hits to remote DRAM caches slower than main memory accesses. These features challenge existing coherence protocols optimized for on-chip caches with fast hits and modest storage capacity. Our solution to these challenges relies on two insights. First, keeping DRAM caches clean avoids the need to ever access a remote DRAM cache on a read. Second, a non-inclusive on-chip directory that avoids tracking blocks in the DRAM cache enables a light-weight protocol for guaranteeing coherence without the staggering directory costs. Our design, called Clean Coherent DRAM Caches (C3D), leverages these insights to improve performance by 6.4–50.7% in a quad-socket system versus a baseline without DRAM caches.
53BP1 and BRCA1 control pathway choice for stalled replication restart (2017)

The cellular pathways that restart stalled replication forks are essential for genome stability and tumor prevention. However, how many of these pathways exist in cells and how these pathways are selectively activated remain unclear. Here, we describe two major fork restart pathways, and demonstrate that their selection is governed by 53BP1 and BRCA1, which are known to control the pathway choice to repair double-strand DNA breaks (DSBs). Specifically, 53BP1 promotes a fork cleavage-free pathway, whereas BRCA1 facilitates a break-induced replication (BIR) pathway coupled with SLX-MUS complex-mediated fork cleavage. The defect in the first pathway, but not DSB repair, in a 53BP1 mutant is largely corrected by disrupting BRCA1, and vice versa. Moreover, PLK1 temporally regulates the switch of these two pathways through enhancing the assembly of the SLX-MUS complex. Our results reveal two distinct fork restart pathways, which are antagonistically controlled by 53BP1 and BRCA1 in a DSB repair-independent manner.
Ecotoxicological Impacts of Micro and Nanoplastics on Marine Fauna (2020)

Mismanagement of plastics has resulted in increasing plastic wastes in the environment, particularly the marine environment acting as the ultimate sink of plastics disposed into waters and even onto land. Micro- and nanoplastics in the marine environment undergo aggregation, sedimentation, deposition and enter the food chains as they are ingested by marine fauna. The uptake of micro- and nanoplastics by marine fauna poses multiple ecotoxicological effects comprising the blockage of alimentary canal and gills, behavioral change, physiological interference especially of the endocrine, antioxidative, immunity and hepatic systems, as well as adverse effects on reproduction and development of marine fauna. The ecotoxicological effects are often complicated by the ability of the micro- and nanoplastics to adsorb a wide range of chemicals. Nanoplastics have been found to affect cellular functions and membrane integrity and are able to cross the blood-brain barrier of certain aquatic species. The effects vary with the types of plastics, species of marine fauna, the dose as well as the sizes of plastics. This review systematically and concisely presents the toxicological effects of micro- and nanoplastics on marine fauna and highlights the need to understand the effects of these plastics at environmental concentrations instead of experimental concentrations. It also calls for the study of ecotoxicological effects of micro- and nanoplastics to be extended to more plastics types and sizes as well as more marine species.
Obstacle avoidance of autonomous vehicles based on model predictive control (2009)

This paper presents an obstacle avoidance scheme for autonomous vehicles as an active safety procedure in unknown environments. Safe trajectories are generated using the non-linear model predictive framework, in which the simplified dynamics of the vehicle are used to predict the state of the vehicle over the look-ahead horizon. To compensate for the slight dissimilarity between the simplified model and the actual vehicle, a separate controller is designed to track the generated trajectory. The longitudinal dynamics of the vehicle are controlled using the inverse dynamics of the vehicle powertrain model, and the lateral dynamics are controlled using a linear quadratic regulator. In the non-linear model predictive framework, to obtain safe trajectories, local obstacle information is incorporated into the performance index using a parallax-based method. Simulation results on a full non-linear vehicle model show that the proposed combination of model-predictive-control-based trajectory generation and tracking controller gives satisfactory online obstacle avoidance performance.
Solid Phase Synthesis of Olefin and Hydroxyethylene Peptidomimetics (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolid Phase Synthesis of Olefin and Hydroxyethylene PeptidomimeticsDavid P. RotellaView Author Information Department of Chemistry, Cephalon, Inc. 145 Brandywine Parkway, West Chester, Pennsylvania 19380 Cite this: J. Am. Chem. Soc. 1996, 118, 48, 12246–12247Publication Date (Web):December 4, 1996Publication History Received5 July 1996Published online4 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja962290ihttps://doi.org/10.1021/ja962290irapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views355Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information SUBJECTS:Absorption,Alcohols,Aldehydes,Organic compounds,Peptides and proteins Get e-Alerts
Fiber optic vibration transducer and analyzer Patent (1967)

Fiber optic transducers for monitoring and analysis of vibration in aerospace vehicles and onboard equipment
Biological filtration in drinking water production (1996)

info:eu-repo/semantics/nonPublished
Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application to <i>in Vivo</i> Metabolic Imaging (2010)

Quantum dots (QD) are inorganic nanocrystals with outstanding optical properties, specially suited for biological imaging applications. Their attachment to biomolecules in mild aqueous conditions for the design of bioconjugates is therefore highly desirable. 1,3-dipolar [3 + 2] cycloaddition between azides and terminal alkynes ("click chemistry") could represent an attractive QD functionalization method. Unfortunately, the use of the popular Cu(I)-catalyzed version of this reaction is not applicable for achieving this goal, since the presence of copper dramatically alters the luminescence properties of QD dispersions. We demonstrate here that copper-free click chemistry, between strained cyclooctyne functionalized QD and azido-biomolecules, leads to highly luminescent conjugates. In addition, we show that QD-cyclooctyne can be used at previously unreported low concentration (250 nM) for imaging the incorporation of azido-modified sialic acid in cell membrane glycoproteins.
Characterization of High Porosity Carbon Electrodes Derived from Mesophase Pitch for Electric Double-Layer Capacitors (2001)

High porosity carbons prepared from mesophase pitch with KOH etching to different extents were used to fabricate electrodes for electric double-layer capacitors. Nitrogen adsorption was used to characterize the porous structure of the carbon electrodes. The performance of the capacitors in 1 was investigated with voltage sweep cyclic voltammetry and constant current charge-discharge cycling. These two electrochemical methods gave fairly close results for capacitance measurements and demonstrated that distributed capacitance along a micropore path affected the capacitor performance. The specific capacitance of the electrodes was found to increase with the specific surface area. However, the capacitance per unit carbon area showed a decreasing trend with the specific area, and this has been attributed to the increased electrode resistance that would probably result from the deepening of the pores upon etching. The highest specific capacitance of was achieved with an electrode consisting of 80% carbon powders with a specific surface area of and 20% polyvinylidenefluoride as the binder. © 2001 The Electrochemical Society. All rights reserved.
Fixture design and overload influence marginal bone loss and future success in the Brånemark® system (1992)

It has been documented that the long-term clinical outcome of the Brånemark system is very favourable. However, failures do occur before and after loading. This study examined the differences in marginal bone loss between standard and self-tapping fixtures and attempted to explain excessive marginal bone loss or loss of osseointegration during the first 3 years of loading. Marginal bone loss (scored on long cone radiographs) and fixture failure rate were compared for different fixture designs. For standard fixtures, in comparison with self-tapping fixtures, the failure rate was clearly higher before as well as after loading. However, for successful fixtures no difference in marginal bone loss was observed. For the conical fixtures an increased marginal bone loss around the smooth part was observed. The effect of fixture overload, marginal bone height and loss of osseointegration was examined in 69 patients with 1 and 15 patients with 2 fixed full prostheses, and in 9 patients with an overdenture in the upper jaw. Excessive marginal bone loss (more than 1 mm) after the first year of loading and/or fixture loss correlated well with the presence of overload due to a lack of anterior contact, the presence of parafunctional activity and osseointegrated full fixed prostheses in both jaws.
On the Construction of Submodule Specifications and Communication Protocols (1983)

The problem of elaborating the specification for the submodules of a system is considered. A new method for the construction of submodule specifications is described. If the system is to consist of n submodules and the system as well as (n -1) submodules are specified, then the method described determines the specification of the additional nth submodule. A formula is given which defines the specification of the additional submodule in the general case where module specifications are given in terms of sets of possible execution sequences, and interaction occurs when several modules participate in the execution of an atomic interaction. For the restricted context of finite-state machines, a constructive algorithm for the evaluation of the formula is given. The use of this design method is demonstrated by examples, including a simple communication protocol involving error detection and retransmission. Possible applications in other areas, as well as remaining problems, are indicated.
Growth of InN on GaAs Substrates by the Reactive Evaporation Method (1989)

InN films are epitaxially grown on GaAs substrates at 450°C by a rf-excited reactive evaporation method. The epitaxial relationship of (0001)InN//(111)GaAs is confirmed from transmission electron diffraction and X-ray diffraction measurements. The value of a full width at half-maximum of the double-crystal X-ray rocking curve for the (0002) diffraction is 17s. Surface morphologies of the InN films are also investigated by scanning electron microscopy.
Effects of Reference Interaural Time and Intensity Differences on Binaural Performance in Listeners with Normal and Impaired Hearing (1995)

On the basis of the results for subjects with hearing impairments, we have reached several conclusions. First, the results for the binaural measurements cannot be explained in terms of available monaural audiometric and psychophysical measurements on these subjects. Second, the subjects' binaural abilities show no significant improvement with any combinations in the reference values of ITD and IID, providing negative evidence for the hypothesis that degraded performance for some subjects may be due to internal interaural offsets in ITD or IID. Third, the hypothesis that binaural detection and ICC discrimination are related, suggested by Durlach et al (1986), is generally supported. Fourth, binaural detection performance is not simply explained in terms of sensitivities to ITD and IID.
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α (2008)

We have reported previously that PX-478 (S-2-amino-3-[4'-N,N,-bis(chloroethyl)amino]phenyl propionic acid N-oxide dihydrochloride) has potent antitumor activity against a variety of human tumor xenografts associated with the levels of the hypoxia-inducible factor-1alpha (HIF-1alpha) within the tumor. We now report that PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. Hypoxia-induced vascular endothelial growth factor formation was inhibited by PX-478, whereas baseline levels of vascular endothelial growth factor in normoxia were unaffected. Studies of the mechanism of PX-478 action showed that HIF-1alpha inhibition occurs in both normoxia and hypoxia and does not require pVHL or p53. In addition, PX-478 decreases levels of HIF-1alpha mRNA and inhibits translation as determined by 35S labeling experiments and reporter assays using the 5' untranslated region of HIF-1alpha. Moreover, to a lesser extent, PX-478 also inhibits HIF-1alpha deubiquitination resulting in increased levels of polyubiquitinated HIF-1alpha. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased. We conclude that PX-478 inhibits HIF-1alpha at multiple levels that together or individually may contribute to its antitumor activity against HIF-1alpha-expressing tumors.
Advancements in the Direct Hydrogen Redox Fuel Cell (2007)

An alternative type of fuel cell in which the air cathode is replaced by the ferric ion was investigated. This hybrid between a polymer electrolyte membrane fuel cell and a redox battery showed promising performance even though components such as the membrane were not optimized. Power densities greater than were achieved with no platinum on the cathode. In addition, the liquid-redox cathode can eliminate the need for humidification and cooling for the fuel cell and provides greater design flexibility. Different aspects of the redox cathode were characterized and showed opportunity for further performance improvement.
Photochemistry of transition-metal phthalocyanines. Analysis of the photochemical and photophysical properties of the acido(phthalocyaninato)rhodium(III) complexes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of transition-metal phthalocyanines. Analysis of the photochemical and photophysical properties of the acido(phthalocyaninato)rhodium(III) complexesG. Ferraudi and S. MuralidharanCite this: Inorg. Chem. 1983, 22, 9, 1369–1374Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/ic00151a021https://doi.org/10.1021/ic00151a021research-articleACS PublicationsRequest reuse permissionsArticle Views133Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts