gebhart/patrepeval huggingface dataset:
Enhancement of gustatory nerve fibers to NaCl and formation of ion channels by commercial novobiocin (1994)

Single fibers of the rat chorda tympani nerve were used to study the mechanism of action of the antibiotic novobiocin on salt taste transduction. In the rat, novobiocin selectively enhanced the responses of sodium-specific and amiloride-sensitive chorda tympani nerve fibers (N type) without affecting more broadly responsive cation-sensitive and amiloride-insensitive fibers (E type). In the presence of amiloride, novobiocin was ineffective at enhancing the response of N-type fibers toward sodium chloride. Novobiocin also increased the conductance of bilayers formed from neutral lipids by forming nonrectifying ion channels with low conductance (approximately 7 pS in 110 mM NaCl), long open times (several seconds and longer), and high cation selectivity. Amiloride did not alter either the conductance or kinetics of these novobiocin channels. These observations suggest that even though novobiocin is able to form cation channels in lipid bilayers, and possibly in cell membranes as well, its action on the salt-taste response is through modulation of existing amiloride-sensitive sodium channels.
Measurement and Identification of Distortion, Alignment, and Mask Errors in IC Processing (1981)

Measurement and identification of misregistration between patterns in integrated circuits is becoming increasingly important as finer geometry processes are being developed for VLSI. Various forms of the Stickman resistor pattern are described. These enable measurement of the alignment errors, mask errors, and distortions that occur when using any alignment apparatus. The properties of the different forms of Stickman resistors are compared and examples of applications to studying mask making errors, slice/mask distortions, projection distortions, and process induced slice distortions are described. It is shown that misregistrations of 0.1 micron or even less can be measured and identified. Direct measurements on simple apparatus are shown to be reproducible to ±0.003 micron and accuracy is estimated at 5% of the misregistration with simple apparatus and 2% for a one micron misregistration if on chip measurement of sheet resistance is made.
Expression of integrin β1 by fibroblasts is required for tissue repair in vivo (2010)

In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue repair, but their tissue-specific role in this process is poorly understood. Here, we show that mice containing a fibroblast-specific deletion of integrin β1 exhibit delayed cutaneous wound closure and less granulation tissue formation, including reduced production of new ECM and reduced expression of α-smooth muscle actin (α-SMA). Integrin-β1-deficient fibroblasts showed reduced expression of type I collagen and connective tissue growth factor, and failed to differentiate into myofibroblasts as a result of reduced α-SMA stress fiber formation. Loss of integrin β1 in adult fibroblasts reduced their ability to adhere to, to spread on and to contract ECM. Within stressed collagen matrices, integrin-β1-deficient fibroblasts showed reduced activation of latent TGFβ. Addition of active TGFβ alleviated the phenotype of integrin-β1-deficient mice. Thus integrin β1 is essential for normal wound healing, where it acts, at least in part, through a TGFβ-dependent mechanism in vivo.
DETROIT OPHTHALMOLOGICAL SOCIETY (1940)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Precise Size Control and Synchronized Synthesis of Six Colors of CdSe Quantum Dots in a Slow-Increasing Temperature Gradient (2007)

The present study describes a simultaneous and highly reproducible large-scale synthesis of six (and more) colors of size-homogeneous and highly luminescent CdSe quantum dots in a single reaction, controlled by a slow-increasing temperature gradient. The described protocol allows a precise control and a synchronized isolation of aliquots of CdSe nanocrystals with defined sizes, avoiding disturbance of the growth of nanocrystals (existing in the reaction mixture) to the isolation of the next aliquot. The obtained quantum dot fractions are of high quality (in 95% size-homogeneous) and have sharp photoluminescence spectra (fwhm approximately 30 nm), quantum yields of 45-70% (in organic solvent), and a lack of aggregation in organic solvents. The method is environmentally friendly as it ensures almost complete utilization of the precursors and productive yield approximately 95%.
A Query Conversion Scheme for Encrypted Cloud Databases (2013)

Encryption is an effective way of protecting sensitive data that have been outsourced in the cloud computing environment. But it is computationally expensive for the database management system to carry out SQL queries against the encrypted data. A query conversion scheme is presented which converts traditional database queries to encryption specific versions so that the queries can be directly executed on the cloud server. This scheme dramatically increases the efficiency of query processing in encrypted cloud databases, and it provides high transparency for end users by introducing a SQL gateway to the user applications and the cloud server.
THE FARMLAND VALUATION REVISITED (2016)

Empirical research is scarce concerning the dynamics of farmland markets which inspire the decision to sell farmlands. This paper explores the real option to postpone the sale of land in farmland valuation. In this article, a real options approach is used to analyze farmland prices behavior using historical cash flow and land price information for Illinois. In general, rising farmland values are primarily dependent on agricultural commodity prices and interest rates. Results suggest that uncertainty about future growth and capital gains is a significant component of farmland market value. Furthermore, this research examines several shift factors of the option value of the state’s farmland by taking into account of uncertainty to improve the analysis of farmland market values.
High temperature gate drive circuits for silicon carbide switching devices (2013)

This paper examines various topologies for the gate-drive circuit for power semiconductors used in high-frequency high-temperature applications. Particular emphasis is placed on transformer-isolated topologies and their implementation using commercially available high-temperature components. Low temperature circuits are built and tested for all candidate configurations. One candidate topology was chosen and built in the high temperature form using commercially available high temperature parts and tested at temperatures up to 200°C.
Clinical experience, complications, and survival in 70 patients with the automatic implantable cardioverter/defibrillator. (1985)

Seventy patients received the automatic implantable defibrillator, five original devices and 72 modified second-generation devices using only bipolar rate sensing and delivering an R wave synchronous cardioverting/defibrillating shock, for either ventricular tachycardia or fibrillation. The primary clinical arrhythmia was sustained ventricular tachycardia in 32 patients, ventricular fibrillation in 20 patients, and both ventricular tachycardia and fibrillation in 18 patients. Before implantation of the device the patients had survived 3.1 +/- 2.3 arrhythmic episodes, including 1.9 +/- 1.7 cardiac arrest, and had received 4.0 +/- 2.1 antiarrhythmic drugs without improvement. Sixty-eight patients ultimately received devices. After a follow-up period of 8.9 +/- 7.7 months (range 1 to 33), 37 patients received a total of 463 discharges. Inability to determine the precise reason for most discharges and the unpleasant nature of the discharges were the major clinical problems encountered. Complications included postoperative death (one patient), lead problems (six patients), inadequate energy requiring explanation (two patients), and pocket infection (one patient. Life-table analysis revealed 6 and 12 month cardiovascular survival of 95.0% and 89.9% and sudden death survival of 98.2%. In our experience, survival with the automatic implantable cardioverter/defibrillator exceeds that with other forms of therapy.
Interactive Quantitative Visualization (1991)

Interactive Quantitative Visualization, a methodology to enhance scientific and engineering computational simulation prototyping, is defined. Appropriate strategies for implementing IQV in a workstation-based distributed computing environment are discussed. Object-oriented graphical tools and a new data management technique to support IQV and computational steering are described. Two examples of IQV and computational steering are presented: 1) a system to allow interactive solution and visualization of nonlinear boundary-value problems; and 2) a modeling exercise illustrating how IQV and computational steering are used together to prototype simulation of a complex physical system, namely a flag flapping in the wind.
The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42 (1998)

The small GTP-binding protein Cdc42 is thought to induce filopodium formation by regulating actin polymerization at the cell cortex. Although several Cdc42-binding proteins have been identified and some of them have been implicated in filopodium formation, the precise role of Cdc42 in modulating actin polymerization has not been defined. To understand the biochemical pathways that link Cdc42 to the actin cytoskeleton, we have reconstituted Cdc42-induced actin polymerization in Xenopus egg extracts. Using this cell-free system, we have developed a rapid and specific assay that has allowed us to fractionate the extract and isolate factors involved in this activity. We report here that at least two biochemically distinct components are required, based on their chromatographic behavior and affinity for Cdc42. One component is purified to homogeneity and is identified as the Arp2/3 complex, a protein complex that has been shown to nucleate actin polymerization. However, the purified complex alone is not sufficient to mediate the activity; a second component that binds Cdc42 directly and mediates the interaction between Cdc42 and the complex also is required. These results establish an important link between a signaling molecule, Cdc42, and a complex that can directly modulate actin networks in vitro. We propose that activation of the Arp2/3 complex by Cdc42 and other signaling molecules plays a central role in stimulating actin polymerization at the cell surface.
Workflow-Centric Information Distribution Through E-Mail (2000)

Organizations require ways to efficiently distribute information such as news releases, seminar announcements, and memos. While the machinery for information storage, manipulation, and retrieval exists, research dealing directly with its distribution in an organizational context is scarce. In this paper, we address this need by first examining the pros and cons of the conventional "mailing lists" approach and then proposing new workflow mechanisms that improve the efficiency and effectiveness of information distribution through e-mail. The proposed approach is relevant to other information distribution approaches beyond e-mail. The main contributions of this study include: (1) offering a workflow perspective on organizational information distribution; (2) analysis of workflows in two new information distribution methods based on dynamic mailing lists and profile matching, respectively; and (3) proposing a new way of matching supply and demand of information that extends existing information filtering algorithms.
Beam-Induced Damage to Thin Specimens in an Intense Electron Probe (2005)

We have investigated the changes produced in single-element and two-layer transmission electron microscope (TEM) specimens irradiated by an intense nanometer-sized electron probe, such as that produced in a field-emission or aberration-corrected TEM. These changes include hole formation and the accumulation of material within the irradiated area. The results are discussed in terms of mechanisms, including electron-beam sputtering and surface diffusion. Strategies for minimizing the effect of the beam are considered.
Calmodulin-binding proteins also have a calmodulin-like binding site within their structure. The flip-flop model. (1991)

The flip-flop model is a mechanistic model proposed to describe how calmodulin activates enzymes. One prediction based upon this model is that calmodulin-activated enzymes would contain a calmodulin-like binding site which, among other attributes, would bind the peptide melittin. Five purified calmodulin-activated enzymes, namely calcineurin, myosin light chain kinase, phosphorylase b kinase, phosphodiesterase, and NAD kinase, were all found to bind biotinylated melittin and to also bind an antimelittin antibody and biotinylated calmodulins. Using gel blots of crude tissue extracts (rat brain and Arabidopsis), most proteins did not bind any of the probes and thus do not have these characteristics. However, among those which bind any of these probes, a strong correlation was found between those proteins which bind biotinylated calmodulins and those which bind melittin and antimelittin. Gel blots of phosphorylase b kinase demonstrate that the alpha, beta, and gamma subunits all bind calmodulin and melittin. A putative calmodulin-like binding site sequence was identified in eight enzymes or subunits which may play an important role in both melittin binding and calmodulin-dependent regulation of these enzymes.
Flash 5! Creative Web Animation (2000)

1. Why Flash? Speed. Web Standard. Interactivity. Ease of Use. Design Capabilities. Versatility. Widespread Viewability. Integration. 2. Getting Started. How Flash Works. What's new in Flash 5. Interface. Options and Settings. Setting Movie Properties. The QuickTime Interactive Tutorials. 3. Graphics. Tools and Options. Drawing Tasks. Using the Pen Tool. Pen and Drawing Preferences. Editing Simple Shapes. Strokes and Fills. Importing Vector Graphics. Optimizing Graphics. Using Color. Interactive Tutorial. 4. Text. What is Text? Creating Text Elements. Working with Text Elements. Using Font Symbols for Dynamic Type Styling. Breaking Text Apart. Animation Considerations. Interactive Tutorial. 5. Sound. Understanding Sounds. Importing Sounds. Adding Sounds to the Timeline. Configuring/Editing Sound Instances. Sound Properties. Updating Sounds. Advanced Sound Capabilities. Using Sounds in Shared Libraries. Interactive Tutorials. 6. Bitmaps. Importing Bitmaps. Adding Bitmaps to your movie. Working With Bitmaps. Bitmap Properties. Optimizing Your Images. Updating Bitmaps. Using Bitmaps in Shared Libraries. Using Animated GIFs. Using PNGs. Interactive Tutorial. 7. Symbols. Understanding Symbols and Instances. Creating Symbols. Editing Symbols. Working With Instances. Interactive Tutorials. 8. Working with Elements on the Stage. Selecting. Groups. Placing Elements on the Stage. Transforming Elements. Duplicating Elements. Cutting, Copying, Deleting, and Pasting. Interactive Tutorial. 9. Using Layers to Separate Content and Functionality. Understanding Layers. Working with Layers. Identifying Graphical Elements on Different Layers. Using Guide Layers. Special-Purpose Layers. Layer Properties. Interactive Tutorials. 10. Using Animation to Build Movement. How Animation Works. Understanding the Timeline. Working with Scenes. Frames. Creating Animation. Putting it all Together. Using QuickTime Video. Interactive Tutorials. 11. Basic Actions for Building Interactivity. Interactivity in Flash. Actions Panel. Basic Actions in Depth. Interactive Tutorials. 12. Building Advanced Interactivity using ActionScript. What is ActionScript? Thinking Like a Programmer. Variables. Operators. Expressions. Statements. Functions. Working with Multiple Timelines. Objects. Smart Clips. The Actions Panel Options Menu. Printing. Interactive Tutorials. 13. Using the Library to Manage Your Assets. The Interface. Managing Library Assets. Working with Symbols in the Library Window. Working with Sounds, Bitmaps, and Videos in the Library Window. Viewing and Organizing Library Items. Special Libraries. Interactive Tutorials. 14. Using Movie Explorer to Manage Structure. Understanding the Display List. Movie Explorer Tasks. Interactive Tutorial. 15. Testing. Getting Ready to Test. Testing Within the Flash Authoring Environment. The Test Movie and Test Scene Commands. The Testing Environment. 16. Publishing Your Work. Delivery Methods. Flash and HTML. Player Issues. Understanding Templates. Interactive Tutorial.
OBS Technologies and permanent seismic Stations at Sea (2003)

An off-shore telemetric system was developed during last 2 years. It consists of a buoy unit, OBS with seismic sensor and digitizer at the sea floor and coaxial cable for transferring data from the sea. The buoy unit includes all components for recording and transmitting data to the base station. A solar panel and wind generator are the sources of energy that charge the batteries in the buoy. An Omni directional antenna and a radio modem are used for data transfer. The buoy can be connected also to mobile network or satellite. The Seismic recording unit is SEDIS IV developed in GeoPro GmbH which is a 6 channel data logger equipped with a hard disk of 30 GByte capacity and a flash memory of 0.5 Gbyte which can continuously record at different sampling rate (from 31.25 to 1000sps). The operating system for SEDIS IV is LINUX, with possible data compression, event location and extraction. The data transfer and supply of the power to seismometer and ADC unit in OBS sphere is done through coaxial cable, connecting the buoy unit and OBS. The whole system was tested for a period of one month (October 2002) within frame of Nestor program in Pilos (Greece) and worked successfully.
A Unified Video Segmentation Benchmark: Annotation, Metrics and Analysis (2013)

Video segmentation research is currently limited by the lack of a benchmark dataset that covers the large variety of sub problems appearing in video segmentation and that is large enough to avoid over fitting. Consequently, there is little analysis of video segmentation which generalizes across subtasks, and it is not yet clear which and how video segmentation should leverage the information from the still-frames, as previously studied in image segmentation, alongside video specific information, such as temporal volume, motion and occlusion. In this work we provide such an analysis based on annotations of a large video dataset, where each video is manually segmented by multiple persons. Moreover, we introduce a new volume-based metric that includes the important aspect of temporal consistency, that can deal with segmentation hierarchies, and that reflects the tradeoff between over-segmentation and segmentation accuracy.
Basic ethers of 1-(p-hydroxyphenyl)-2-phenyl-1,2,3,4-tetrahydroquinoline and 1-(p-hydroxyphenyl)-2-phenylindole. Antifertility agents (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBasic ethers of 1-(p-hydroxyphenyl)-2-phenyl-1,2,3,4-tetrahydroquinoline and 1-(p-hydroxyphenyl)-2-phenylindole. Antifertility agentsMalcolm Rice. Bell, Andrew W. Zalay, Rudolf. Oesterlin, Philip. Schane, and Gordon O. PottsCite this: J. Med. Chem. 1970, 13, 4, 664–668Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://pubs.acs.org/doi/10.1021/jm00298a019https://doi.org/10.1021/jm00298a019research-articleACS PublicationsRequest reuse permissionsArticle Views130Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Semantics for a real-time object-oriented programming language (2002)

Presents a framework to define a semantics for a real-time object-oriented programming language and to verify programs written in the language. The semantics is defined as the collection of translation rules that map the syntactic constructions of the language into expressions in a process calculus extended with the notion of time. By using the expressive capabilities of the calculus, the semantics can appropriately capture temporal features of the language such as timeout exception and execution time, and concurrent object-oriented features such as concurrency, class, and object creation. Particularly, since it can restrict the number of concurrent activities which take place simultaneously, it allows one to analyze and predict the temporal and behavioral properties even of programs executed with a number of processors smaller than the number of active objects. Through an example, we illustrate a method of analyzing real-time programs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Coccidioidomycosis in Arizona: Increase in Incidence from 1990 to 1995 (1998)

The number of cases of coccidioidomycosis (incidence) reported to the Arizona Department of Health Services increased from 255 (7.0 per 100,000 population) in 1990 to 623 (14.9 per 100,000 population) in 1995 (P < .001). Four counties in the south central region of the state, which contained 80% of the state's population, had the largest increase and accounted for 95% of all cases in 1995. Cases in persons aged 65 years or older and men were reported more frequently (for both, P < .001). During 1995, 890 patients were discharged from Arizona hospitals with a diagnosis of coccidioidomycosis. Rates of hospitalization were greater among persons aged 55 years or older, men, and African-American (for all three, P < .01). Of the hospitalized patients, 48 died, and 12 (25%) of these patients had a concurrent diagnosis of human immunodeficiency virus infection. These data demonstrate that coccidioidomycosis is a growing health problem in Arizona.