gebhart/patrepeval huggingface dataset:
Ethnopharmacological Evaluation of Peristrophe bicalyculata Nees. for Anti-inflammatory and Analgesic Activity (2003)

The ethanolic (50% v/v) extracts of Peristrophe bicalyculata Nees. (Acanthaceae) were examined for anti-inflammatory and analgesic activities in experimental animals. P. bicalyculata in doses of 50, 100 and 200 mg/kg caused a dose dependent inhibition of swelling caused by carrageenin equivalent to 12.25-24.49% protection and 16.62-39.44% in cotton pellet induced granuloma in rats. There was a significant increase in the tail-flick reaction time in mice (18.05-76.43% protection) and analgesy-meter induced pain in rats (14.49-56.85%) protection). The extract of P. bicalyculata resulted in an inhibition of stretching episodes and the protection range of 14.49-56.85% respectively in acetic acid induced writhing.
The waveform description language: moving from implementation to specification (2002)

Many current research and development activities make significant contributions to the quality of some particular implementation approach. We describe the waveform description language, in which the best characteristics of a variety of distinct programming approaches are exploited so that standard implementation domain practices can be applied in the specification domain. A single WDL specification may be refined to support semi-automated conversion to a variety of implementations. A WDL specification avoids the ambiguities and contradictions characteristic of many conventional specifications with an underlying formality that remains accessible and familiar to programmers.
Single electron amplification in a "single-MCP + micromegas + pads" detector (2004)

We have tested a new gaseous detector structure based on a tandem of two parts, the first one is a single MCP plate (sometimes called the Microchannel plate or capillary plates), and the second one is a Micromegas with pad readout. The new detector responds very well to a single electron signal, both in helium-based and argon-based gases, and it can reach a very large gain. Our overall aim is to couple the proposed electrode structure to a Bialkali photocathode. The main advantage of this avenue of research is that such a detector would operate easily in a very large magnetic field, and it could achieve excellent position resolution and large pixelization, compared to existing vacuum-based MCP-PMT detectors.
Synthesis and Anti-HSV Activity of Methylenedioxy Mappicine Ketone Analogs (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Anti-HSV Activity of Methylenedioxy Mappicine Ketone AnalogsIsrail Pendrak, Robert Wittrock, and William D. KingsburyCite this: J. Org. Chem. 1995, 60, 9, 2912–2915Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/jo00114a050https://doi.org/10.1021/jo00114a050research-articleACS PublicationsRequest reuse permissionsArticle Views1392Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Studies in fault detection with the reflection seismograph (1949)

Abstract Faulting has long been recognized as an important factor in the formation of traps for the accumulation of oil and gas. A discussion is presented of some of the problems connected with fault interpretation, together with suggestions as to methods which may be employed to assist in the solution. Field data and final fault interpretation of a peculiar problem are herein illustrated.
Carbapenem and penem antibiotics. IV. Synthesis and antibacterial activity of (5R*,6S*)-6-((R*)-1-hydroxyethyl)-2-functionalized-methyl carbapenem and penem derivatives. (1985)

Racemic 2-acetoxymethyl and 2-(heteroaromatic) thiomethyl carbapenem and penem antibiotics having a 1-(R*)-hydroxyethyl side-chain at C-6 (6, 7, 8, and 45, 59, 47, 49, 51) were synthesized, and their antibacterial activities were determined.
Expression of MicroRNAs in Patients With Pancreatic Cancer and Its Prognostic Significance (2012)

The tumorigenic role of miR-21 and miR-155 was confirmed, whereas down-regulation of miR-31, miR-145, and miR-146a, in dispute with current literature, renders necessary the revision of use of microRNAs as biological markers.
Cloning and delimiting one chloroplast DNA replicative origin of<i>Chlamydomonas</i> (1984)

The EcoR1 restriction fragments containing D-loops which marked the replication origin of chloroplast DNA were identified in two different species of Chlamydomonas. Each fragment was cloned in the E. coli plasmid pBR325. The cloned fragments were compared by restriction endonuclease analyses and by heteroduplex analyses in the electron microscope. The relative position of the D-loop regions and the homologous regions between the 2 fragments was determined. The D-loops were located within one short homologous region of 0. 42kb in length between the 2 cloned restriction fragments. The homologous region was subcloned in pBR322. Closed circular plasmid DNAs containing the short homologous region showed preferred denaturation in the D-loop region under physiological salt concentration which suggested that D-loop region was AT rich. Sequence divergence was detected at both ends of the D-loop region. Southern blot analyses indicated the presence of species-specific repetitive sequences within the divergent regions.
Phytochemical, Antioxidant and Antimicrobial study ofFlowers of Nyctanthes arbor-tristis Linn. (2011)

Nyctanthes arbor-tristis flowers were collected in the month of August from the Manipal region of the India. The flowers were shed dried, powdered and extracted with ethanol in soxhlet apparatus. Dried ethanolic extract was further subjected to fractionation by using petroleum ether, diethyl ether and ethyl acetate solvents in the order of increasing polarity. Phytochemical screening of flower extract showed the presence of volatile oils, phenolic compounds and
iridoids. Petroleum ether and diethyl ether fraction showed the significant antioxidant activity. Among the fractions tested for antibacterial activity, petroleum ether and diethyl ether showed moderate antibacterial activity against both gram positive and gram negative species. None of the
tested fraction showed significant antifungal activity.
Regression of Atherosclerosis by the Intravenous Infusion of Specific Biochemical Nutrient Substrates in Animals and Humans (1987)

Preliminary studies in 400 New Zealand albino rabbits produced a reliable animal model of nutrient-induced atherosclerosis that simulated that observed in humans. Atherosclerosis was then induced in an additional 1600 rabbits in sets of 40 animals each, maintaining plasma cholesterol concentrations between 1000 and 2000 mg/dL for 6-20 weeks. In each set, 10 control rabbits were killed to document baseline atherosclerosis, and the other 30 rabbits were assigned randomly to one of three groups of 10 rabbits. Groups of 10 rabbits were either continued on the atherogenic diet (group I), given standard laboratory rabbit pellets (group II), or infused continuously with specially formulated anticholesterol solutions via central venous catheters (group III) for 6 weeks. At autopsy, atherosclerotic lesions consistently involved 85-95% of the aorta in group I. In group II, atherosclerosis was comparable with the baseline control group with no regression. In group III, regression of atherosclerosis by 90-95% was consistently documented. Correlations between plasma amino acids and plasma cholesterol concentrations were established in four humans with severe atherosclerosis to maximize the cholesterol reduction capacity of the amino acid formulation. Infusion of the modified total parenteral nutrition solution induced prompt reduction in plasma cholesterol levels by 40-60% regardless of the initial level and was accompanied by evidence of regression of atherosclerosis after a 90-day infusion therapy period.
Microstructural characterization and mechanical properties of high power ultrasonic spot welded aluminum alloy AA6111–TiAl6V4 dissimilar joints (2014)

Aluminum alloy AA6111 and TiAl6V4 dissimilar alloys were successfully welded by high power ultrasonic spot welding. No visible intermetallic reaction layer was detected in as-welded AA6111/TiAl6V4 welds, even when transmission electron microscopy was used. The effects of welding time and natural aging on peak load and fracture energy were investigated. The peak load and fracture energy of welds increased with an increase in welding time and then reached a plateau. The lap shear strength (peak load) can reach the same level as that of similar Al–Al joints. After natural aging, the fracture mode of welds transferred from ductile fracture of the softened aluminum to interfacial failure due to the strength recovery of AA6111.
Characterisation of a catabolic epoxide hydrolase from a <i>Corynebacterium</i> sp. (1998)

The epoxide hydrolase (EH) from Corynebacterium sp. C12, which grows on cyclohexene oxide as sole carbon source, has been purified to homogeneity in two steps, involving anion exchange followed by hydrophobic-interaction chromatography. The purified enzyme is multimeric (probably tetrameric) with a subunit size of 32,140 Da. The gene encoding Corynebacterium EH was located on a 3.5-kb BamHI fragment of C12 chromosomal DNA using a DNA probe generated by PCR using degenerate primers based on the N-terminal and an internal amino acid sequence. Sequencing and database comparison of the predicted amino acid sequence of Corynebacterium EH shows that it is similar to mammalian and plant soluble EH, and the recently published sequence of epichlorohydrin EH from Agrobacterium radiobacter AD1 [Rink, R., Fennema, M., Smids, M., Dehmel, U. & Janssen, D. B. (1997) J. Biol. Chem. 272, 14650- 14657), particularly around the catalytic site. All of these proteins belong to the alpha/beta-hydrolase-fold family of enzymes. Similarity to the mammalian microsomal EH is weaker.
Simulation and performance evaluation of DAG construction with RPL (2012)

In this paper, we simulate and analyze the performance of the network formation process with the RPL (IPv6 Routing Protocol for Low Power and Lossy Networks), which is a routing protocol specifically designed for Low power and Lossy Networks (LLN) compliant with 6LoWPAN (IPv6 Low power Wireless Personal Area Networks). One motivation behind this work is that RPL is the first prospective candidate routing protocol for low-power and lossy networks, which are a main component in the next generation Internet-of-Things. RPL is still under development, although having gained maturity, and is open to improvements. Indeed, there is a need to understand well its behavior, and investigate its relevance. Our analysis is based on the ContikiRPL accurate and realistic simulation model developed under Contiki operating system. The performance of RPL is evaluated and analyzed for different network settings to understand the impact of the protocol attributes on the network formation performance, namely in terms energy, storage overhead, communication overhead, network convergence time and the maximum hop count. We argue through simulation that RPL provides several features that make it suitable to large scale networks.
FUTURE PROSPECTS (1985)

An important taks is the selection of the future generation of antiviral compounds, and no consensus is apparent on how this problem should be approached. Meanwhile, a judicious mixture of two important antivirals, namely acyclovir and amantadine, but could more compounds be selected by applying biochemical screening using viral enzymes or by using the greatly increased knowledge of viral protein and nucleic acid sequences? For example, sequence studies have shown, rather surprisingly that only a few mutations in an RNA virus genome can change a virulent virus into an attenuated one. It is possible, therefore, that a hit on a single target by an antiviral could be very effective. Important target viruses such as influenze, herpes viruses and picornaviruses and have rather unique enzymes, including RNA and DNA polymerasea, while their proteins have specific functions, which may be interrupted by drugs, including fusion sites and recognition sites for cellular receptors. Current work on antiviral short peptides and inhibitors of virus enzymes and viral induced fusion is reviewed. More specific targets are the neuraminidase and also the mRNA 5′ cap binding enzyme activities of influenza and the ribonucleotide reductase enzyme of herpes virus. A possible broad approach is the synthesis of analogues of 2′–5′ oligo A, an important mediator of interferon action. The actual use of antivirals in the field also needs careful thought, including ways of avioding the emergence of drug resistant viruses. These laboratory and clinical aspects present a considerable, but surely solvable challenge to antiviral chemotherapists
Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after interleukin 2 therapy. (1996)

Recent studies have demonstrated altered expression and function of signaling molecules in T and natural killer cells in patients with cancer. The impairment of immune cell functions in advanced cancer may result from defects in signal transduction. We studied purified T cells obtained from peripheral blood or tumor-involved lymph nodes (LNs) of 45 patients with advanced metastatic melanoma for the presence of abnormalities in expression or activity of various signaling molecules. Western blot analyses demonstrated reduced expression of CD3-zeta in 10 of 11 preparations of T cells obtained from tumor-involved LNs. Similar reduction in expression of CD3-zeta was demonstrated by immunostaining performed in situ on frozen sections of melanoma tissues. Expression of p56(lck) and Zap-70, but not phospholipase C-gamma1, was reduced in these patients' T cells relative to those obtained from normal individuals. In 50% of the patients, reduced expression of CD3-zeta and p56(lck) was observed in T lymphocytes obtained both from tumor-involved LNs and from peripheral blood. To determine whether deficient expression of these signaling molecules is reversible, T cells from melanoma-involved LNs were incubated in the presence of interleukin 2 (IL-2) for 48 h, and lysates from fresh or cultured lymphocytes were compared for changes in expression of signaling molecules. Cells cultured in the presence of IL-2 demonstrated increased expression of CD3-zeta and p56(lck), which approached the levels detected in normal T cells. However, the level of p56(lck) kinase activity did not normalize in any of the LN-derived lymphocytes cultured in the presence of IL-2. Decreased expression of CD3-zeta or p56(lck) observed in the patients' T cells was not reversed by immunotherapy with IL-2 at low or high dose in those patients with metastatic melanoma who failed to respond to therapy. However, in three patients who achieved clinical responses, the initially reduced expression of zeta in peripheral blood T cells normalized following IL-2 therapy.
Prevention and management of vision loss relating to facial filler injections (2016)

Steps to prevent and manage vision loss based on current evidence and best clinical practices are outlined in this paper. Empirical referral to any emergency department or untrained doctors may lead to inordinate delays and poor outcomes for the affected eye.
Formation of Network and Cellular Structures by Viscoelastic Phase Separation (2009)

Abstract Network (sponge) and cellular structures are often seen in various types of materials. Materials with such structures are generally characterized by light weight and high mechanical strength. The usefulness of such materials is highlighted, for example, by the remarkable material properties of bone tissue, which often has a highly porous structure. In artificial materials, plastic and metallic foams and breads have such structures. Here, we describe a physical principle for producing network and cellular structures using phase separation, and its potential applications to the morphological control of materials spanning from soft to hard matter.
Electric field gradients and band sharpening in DNA gel electrophoresis (1988)

A mathematical study of the effect of non-uniform electric fields on the width of DNA electrophoretic bands is presented. Using a simple model, we show that field gradients sharpen these bands during an experiment if the corresponding gradient of electrophoretic velocity is large enough. This is in agreement with experimental results indicating that narrower bands form when pulsed field electrophoresis is carried out in the presence of field gradients. Moreover, it is shown that there is in fact an optimal experimental duration that maximizes separation. Finally, gradients are also predicted to reduce the relative mobilities of the DNA fragments, which is a serious drawback of this technique.
Wireless home automation networks for indoor surveillance: technologies and experiments (2014)

Abstract The use of wireless technologies for critical surveillance and home automation introduces a number of opportunities as well as technological challenges. New emerging technologies give the opportunity to exploit the full potential of the internet of things paradigm by augmenting existing wired installations with smart wireless architectures. This work gives an overview of requirements, characteristics, and challenges of wireless home automation networks with special focus on intrusion detection systems. The proposed wireless network is based on several sensors that are deployed over a monitored area for detecting possible risky situations and triggering appropriate actions in response. The network needs to support critical traffic patterns with different characteristics and quality constraints. Namely, it should provide a periodic low-power monitoring service and, in case of intrusion detection, a real-time alarm propagation mechanism over inherently unreliable wireless links subject to fluctuations of the signal power. Following the guidelines introduced by recent standardization, this paper proposes the design of a wireless network prototype at 868 MHz which is able to satisfy the specifications of typical intrusion detection applications. A proprietary medium access control is developed based on the low-power SimpliciTI radio stack (Texas Instruments Incorporated, San Diego, CA, USA). Network performance is assessed by experimental measurements using a test-bed in an indoor office environment with severe multipath and nonline-of-sight propagation conditions. The measurement campaigns highlight the potential of the sub-GHz technology for cable replacing.
Highly sensitive targeted methylome sequencing by post-bisulfite adaptor tagging (2014)

The current gold standard method for methylome analysis is whole-genome bisulfite sequencing (WGBS), but its cost is substantial, especially for the purpose of multi-sample comparison of large methylomes. Shotgun bisulfite sequencing of target-enriched DNA, or targeted methylome sequencing (TMS), can be a flexible, cost-effective alternative to WGBS. However, the current TMS protocol requires a considerable amount of input DNA and hence is hardly applicable to samples of limited quantity. Here we report a method to overcome this limitation by using post-bisulfite adaptor tagging (PBAT), in which adaptor tagging is conducted after bisulfite treatment to circumvent bisulfite-induced loss of intact sequencing templates, thereby enabling TMS of a 100-fold smaller amount of input DNA with far fewer cycles of polymerase chain reaction than in the current protocol. We thus expect that the PBAT-mediated TMS will serve as an invaluable method in epigenomics.
Splicing factor mutations predict poor prognosis in patients with <i>de novo</i> acute myeloid leukemia (2016)

Mutations in splicing factor (SF) genes are frequently detected in myelodysplastic syndrome, but the prognostic relevance of these genes mutations in acute myeloid leukemia (AML) remains unclear. In this study, we investigated mutations of three SF genes, SF3B1, U2AF1 and SRSF2, by Sanger sequencing in 500 patients with de novo AML and analysed their clinical relevance. SF mutations were identified in 10.8% of total cohort and 13.2% of those with intermediate-risk cytogenetics. SF mutations were closely associated with RUNX1, ASXL1, IDH2 and TET2 mutations. SF-mutated AML patients had a significantly lower complete remission rate and shorter disease-free survival (DFS) and overall survival (OS) than those without the mutation. Multivariate analysis demonstrated that SFmutation was an independent poor prognostic factor for DFS and OS. A scoring system incorporating SF mutation and ten other prognostic factors was proved very useful to risk-stratify AML patients. Sequential study of paired samples showed that SF mutations were stable during AML evolution. In conclusion, SF mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression. These mutations may be potential targets for novel treatment and biomarkers for disease monitoring in AML.
An Ensemble Approach to Retrieving Water Quality Parameters from Multispectral Satellite Imagery (2018)

This research proposes an approach based on the ensemble of multiple empirical algorithms to better estimate chlorophyll-a (Chl-a) concentration as the proxy for algal blooms in inland waters from Sentinel-2A (S2A) multispectral imagery. Recent studies on Chl-a retrieval from newly launched S2A satellite imagery mainly use a single/individual empirical algorithm. So far, no research effort has been made to synthesize the information From different empirical models for improving the estimation accuracy. Using S2A image data and coincident extensive in situ water truth data, we compared a number of empirical algorithms, among which 2BDA, 3BDA, and NDCI yield the lowest RMSE of 4.50, 4.57, and 4.71μ/L respectively. An optimally weighted combination ensemble method by pseudoinverse technique reduces the RMSE to 4.071μ/L. Our proposed spectral space partition guided ensemble method that exploits advantages of each individual algorithm can further reduce the RMSE to 3.57μ/L, 20.6% improvement over the best individual algorithm.