gebhart/patrepeval huggingface dataset:
Novel LC pseudo switched capacitor filter suited for wireless RF applications (2005)

Switched capacitor filters have been in wide-spread used for a few years, for the realization of stable, accurate and high quality filters for operating frequencies below the megahertz range. This paper would like to prove the feasibility of a novel tuned LC pseudo switched capacitor filter with high quality factor of several hundreds for wireless radio frequency applications. The filter is designed with standard 0.35µm silicon BiCMOS technology. Experimental results at 442MHz switching frequency demonstrate interesting performances; the quality factor is equal to 316 for a frequency bandwidth equals to 1.4MHz.
Enzymatic corn wet milling: engineering process and cost model (2009)

The E-milling process was found to be cost competitive with the conventional process during periods of high corn feedstock costs since the enzymatic process enhances the yields of the products in a corn wet milling process. This model is available upon request from the authors for educational, research and non-commercial uses.
Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment (2007)

Levodopa is the most effective drug for treating Parkinson's disease. However, long-term use of levodopa is often complicated by significantly disabling fluctuations and dyskinesias negating its beneficial effects. Younger age of Parkinson's disease onset, disease severity, and high levodopa dose increase the risk of development of levodopa-induced dyskinesias (LID). The underlying mechanisms for LID are unclear though recent studies indicate the importance of pulsatile stimulation of striatal postsynaptic receptors in their pathogenesis. The non-human primates with MPTP-induced parkinsonism serve as a useful model to study dyskinesia. Once established, LID are difficult to treat and therefore efforts should be made to prevent them. The therapeutic and preventative strategies for LID include using a lower dosage of levodopa, employing dopamine agonists as initial therapy in Parkinson's disease, amantadine, atypical neuroleptics, and neurosurgery. LID can adversely affect the quality of life and increase the cost of healthcare.
NEW YORK 不朽发明 (2008)

美国建筑师Buckminster Fuller以前瞻性闻名于世。正在纽约Whitney艺术博物馆举行的Buckminster Fuller:Starting with the Universe展览中.策展人尝试为他重拾二十一世纪设计巨匠之名.试图重新评价他所取得的个人成就.以及他对整个设计
First Real-Time Data Recovery for Synchronous QPSK Transmission With Standard DFB Lasers (2006)

For the first time, synchronous quadrature phase-shift keying data is recovered in real-time after transmission with standard distributed feedback lasers using a digital inphase and quadrature receiver. Forward-error-correction-compatible performance is reached at 800 Mb/s after 63 km of fiber. Self-homodyne operation with an external cavity laser is error-free
The Cincinnati incision: a comprehensive approach for surgical procedures of the foot and ankle in childhood. (1982)

We are describing a transverse incision that we have found useful in performing surgical procedures involving extensive dissection of the posterior, medical, and lateral aspects of the foot and ankle. Operative procedures using this incision have been performed on 154 feet in ninety-nine patients who were less than fifteen years old and who had an average follow-up of eighteen months. The incision is transverse and extends from the anteromedial to the anterolateral aspect of the foot over the back of the ankle at the level of the tibiotaler joint. Depending on the requirements of the procedure, either the anteromedial or posterolateral portion of the incision, or the complete incision, may be used. The incision improves visualization of the medial, posterior, and lateral aspects of the foot and ankle, while at the same time resulting in excellent healing of the wound and an improved cosmetic appearance compared with the more commonly used vertical incisions.
Ultra-stable optical frequencies for space (2003)

Attracted by the prospect of vastly increased bandwidth, a move from the microwave to the optical for space-based communications is now underway. It is important to consider the associated optical frequency source requirements. "Direct detection" systems have been considered for the first phase of commercial intersatellite optical-communication links. "Coherent communication", which offers at least an order of magnitude improvement in capacity, requires spectrally narrow sources, and is more difficult to implement. Ultra-narrow lasers will be needed for low data-rate applications such as the Deep-Space Network (DSN). The required stability and accuracy of the lasers will also depend on the additional demands of any navigation, tracking and "radio/light science" functions served. Cavity-stabilised narrow lasers are expected to be the basis of the best laser oscillators operating in the optical for space applications.
PROBLEMS CONCERNING DEMENTIA PRAECOX (1936)

CURRENT LITERATURE: III. SYMBOLIC NEUROLOGY: PSYCHOLOGY, PSYCHOANALYSIS, PSYCHONEUROSIS. PSYCHOSES: PDF Only
Intracellular spiral inclusions in cerebral cell processes in Creutzfeldt-Jakob disease. (1981)

Electron microscopic examination of brain biopsy specimens from two patients with Creutzfeldt-Jakob disease revealed the presence of intracellular membranous spiral inclusions in the processes of cortical cells. These inclusions, 375 nm to 660 nm in length and 50 nm to 88 nm in width, resemble similar structures reported in a patient with the same disease by Bastian and, more recently, in a second patient by Gray et al. These inclusions bear close morphologic resemblance to spiroplasma organisms, a wall-free prokaryote known to cause a "slow-virus"-like disorder in mice.
Insulin and interleukin-1 differentially regulate pp63, an acute phase phosphoprotein in hepatoma cell line. (1994)

We have reported previously that the phosphoprotein pp63, an acute phase protein, which has been recently identified as the rat fetuin, was capable of blocking the mitogenic effect of insulin on the rat Fao hepatoma cell line, without affecting metabolic effects of the hormone. Only the phosphorylated form of the protein has been shown to exhibit both anti-tyrosine kinase and growth inhibitory properties. In this study, we used the FTO-2B rat hepatoma cell line to analyze the mechanisms involved in the control of synthesis and/or phosphorylation of pp63. For this purpose, we investigated the action of effectors known to modulate hepatic functions, such as cytokines (interleukin (IL)-1 beta and IL-6), which regulate the production of acute phase proteins, and insulin, which elicits profound effects on hepatocyte metabolism. Here, we demonstrate that IL-1 beta diminished markedly the pp63 production by affecting its mRNA transcription and that the cytokine was able to modify the N-glycosylation process of the protein. In contrast, insulin did not affect the biosynthesis of pp63 but dramatically decreased its extent of phosphorylation.
Organization of genes encoding membrane proteins of the <i>Escherichia coli</i> ferrienterobactin permease (1991)

Transposon mutagenesis and plasmid complementation studies have identified two genes, fepD and fepG, which are essential for ferrienterobactin transport in Escherichia coli. These genes mapped in the enterobactin gene cluster and genetic evidence indicated that they are transcribed as part of an operon (fepD, fepG, fepC). The nucleotide sequence of fepD was determine; it could encode a hydrophobic 33.8 kDa protein with sequence homologies to other iron and vitamin B12 transport proteins. Also identified, between fepD and fepB, was an open reading frame (ORF43) with no detectable function; its 43 kDa protein product (P43) was seen on polyacrylamide gels. The fepD-C operon and ORF43 were divergently transcribed from a 110bp region containing a binding site for the repressor protein Fur.
Response Suppression in V1 Agrees with Psychophysics of Surround Masking (2003)

When a target stimulus is embedded in a high contrast surround, the target appears reduced in contrast and is harder to detect, and neural responses in visual cortex are suppressed. We used functional magnetic resonance imaging (fMRI) and psychophysics to quantitatively compare these physiological and perceptual effects. Observers performed a contrast discrimination task on a contrast-reversing sinusoidal target grating. The target was either presented in isolation or embedded in a high-contrast surround. While observers performed the task, we also measured fMRI responses as a function of target contrast, both with and without a surround. We found that the surround substantially increased the psychophysical thresholds while reducing fMRI responses. The two data sets were compared, on the basis of the assumption that a fixed response difference is required for correct discrimination, and we found that the psychophysics accounted for 96.5% of the variance in the measured V1 responses. The suppression in visual areas V2 and V3 was stronger, too strong to agree with psychophysics. The good quantitative agreement between psychophysical thresholds and V1 responses suggests V1 as a plausible candidate for mediating surround masking.
T-matrix method for modelling optical tweezers (2010)

We review the use of the T-matrix description of scattering, or the T-matrix method, for the calculation of optical forces and torques, especially for the computational modelling of optical tweezers. We consider both simple particles such as homogeneous isotropic spheres, spherical shells, spheroids, and so on, and complex particles, including anisotropic particles, inhomogenous particles, and geometrically complex particles.
Calculations of resonance Raman cross sections in forbidden electronic transitions: Scattering of the 992 cm−1 mode in the 1<i>B</i>2<i>u</i> band of benzene (1978)

Strictly dipole forbidden electronic states are shown to be possible sources of Raman cross section for the scattering of totally symmetric fundamentals. In particular, the absolute scattering cross section and depolarization ratio of the 992 cm−1 a1g mode in benzene are calculated in the region of the electronically forbidden 1B2u transition. The molecular polarizability in this region is derived from two principle sources. One is the preresonance contribution of an effective electronic transition in the deep vacuum ultraviolet. The other is due to contributions from the vibrational substructure of the 1B2u transition which vary in sign. Interference effects lead to interesting resonance profiles for both the scattering cross section and the depolarization ratio. The in-resonance contributions to the polarizability are determined by a semiempirical approach to the summation over all vibrational subspaces. The damping constant need not serve as an artifical breadth parameter when that breadth is not lifetime limited. Once the complete vibrational subspace has been included in the theory much smaller values of the damping constant than previously used can be accommodated.
Nature of the highly conducting interfacial layer in GaN films (2000)

Using several scanning probe techniques to investigate local electronic properties, we show that the GaN/sapphire interfacial region contains ⩾ ten times higher electron density but with the Fermi level being 50–100 meV deeper in the band gap compared to the less-conducting bulk film. This anomalous behavior cannot be explained by transport in the intrinsic conduction band of GaN. Rather, it points to the existence of a partially filled donor impurity band. We relate the presence of this impurity band conduction to excess oxygen in the region and the defective microstructure at the GaN/sapphire interface.
Effect of Midtreatment PET/CT-Adapted Radiation Therapy With Concurrent Chemotherapy in Patients With Locally Advanced Non–Small-Cell Lung Cancer (2017)

clinicaltrials.gov Identifier: NCT01190527.
Induction and Regulation of Endogenous Granulocyte Colony-Stimulating Factor Formation (2002)

Granulocyte colony-stimulating factor (G-CSF) is one of the most prominent endogenous proteins in broad clinical use. While its biological and clinical effects are relatively well studied, little is known about its endogenous formation in health and disease. However, such knowledge is crucial to decide in which situations G-CSF should be applied efficiently in the clinic, ie. when endogenous production does not suffice. The dramatic changes induced by G-CSF in the differential blood cell count are directly immunomodulatory, strengthening the innate defence by multiplying neutrophilic granulocytes. A multitude of further immunomodulatory effects contribute to the regulation of the concerted host defence. In this review, following a short introduction into the biology of G-CSF, the available data on endogenous formation in a number of animal models and human diseases is compiled. The cellular sources and inducers of G-CSF formation are reviewed and the regulation of G-CSF expression on both the transcriptional and translational level are discussed. The emerging understanding of the role and regulation of endogenous G-CSF formation opens up possibilities to define therapeutic windows as well as targets for diagnostics or drug development. Lastly, the modulation of G-CSF formation by various pharmacological agents alerts to putative side effects of these drug treatments.
Improved apparatus for the NMR measurement of self-diffusion coefficients using pulsed field gradients (1974)

The characteristics of some quadrupole coils are examined to determine their suitability for NMR pulsed field gradient diffusion measurements. They are found to be capable of acceptable field gradient uniformity, low ratio of inductance to field gradient strength, low dc resistance and their windings are as far as possible from adjacent pole faces, thus minimising eddy current formation. An improved current pulser using SCR's is also discussed.
Formation of droplet interface bilayers in a Teflon tube (2016)

Droplet-interface bilayers (DIBs) have applications in disciplines ranging from biology to computing. We present a method for forming them manually using a Teflon tube attached to a syringe pump; this method is simple enough it should be accessible to those without expertise in microfluidics. It exploits the properties of interfaces between three immiscible liquids, and uses fluid flow through the tube to pack together drops coated with lipid monolayers to create bilayers at points of contact. It is used to create functional nanopores in DIBs composed of phosphocholine using the protein α-hemolysin (αHL), to demonstrate osmotically-driven mass transfer of fluid across surfactant-based DIBs, and to create arrays of DIBs. The approach is scalable, and thousands of DIBs can be prepared using a robot in one hour; therefore, it is feasible to use it for high throughput applications.
Prostate cancer: Flow cytometric methods for detection of bone marrow micrometastases (1996)

Up to 60% of patients with clinically localized prostate cancer will relapse despite potentially curative local treatment. Current staging tests have been limited in adequately identifying individual patients who are at a high risk for future relapse. Detection of bone marrow micrometastases may identify individuals destined to develop clinically detectable systemic metastases. Although immunohistochemistry and molecular approaches are being investigated, the most ideal test(s) are yet to be determined. In this report we describe methods for specific detection and isolation of prostate cancer micrometastases by multi-parameter rare event flow cytometric analysis. A model was developed and validated using three human prostate cancer cell lines, healthy donor marrow, dual marker labeling for cytokeratin (epithelial-specific marker) and CD45 (bone marrow-specific marker). The detection sensitivity of this model was at the level of one prostate cancer cell in 100,000 nucleated bone marrow cells. As a part of an ongoing clinical study, bone marrow aspirates from 15 patients with newly diagnosed prostate cancer have been analyzed. Six patients were found to have cytokeratin positive/CD45 negative cells in their bone marrow aspirates. We conclude that flow cytometric rare event analysis provides a sensitive and specific assay for detection of bone marrow micrometastases in patients with clinically localized prostate cancer.
Cardiac sympathetic afferent reflex in dogs with congestive heart failure (1996)

It is well accepted that sympathetic tone is elevated in chronic heart failure (HF) and that the cardiac sympathetic afferent reflex is a sympathoexcitatory reflex. There have been no studies designed to examine the role of this reflex in control of sympathetic outflow in the HF state. In this study we tested the hypothesis that cardiac sympathetic afferent reflexes are enhanced in HF and are, therefore, capable of contributing to the increase in sympathetic outflow in this disease state. Ventricular pacing was carried out in 14 dogs until signs of HF were evident. Fourteen sham dogs served as controls. At the time of the acute experiment the dogs were anesthetized with alpha-chloralose. The hemodynamic [arterial pressure and heart rate (HR)] and renal sympathetic nerve activity (RSNA) responses to left ventricular epicardial application of two doses of bradykinin (BK) and capsaicin (Cap) were determined in the sinoaortic-denervated and vagotomized state. The MAP, RSNA, and HR responses to BK were greater in the HF group compared with the sham group. The RSNA response to BK (50 micrograms) in the HF group was significantly increased (34.0 +/- 5.9 vs. 11.5 +/- 4.2%, P < 0.05). The MAP, RSNA, and HR responses to Cap in the HF group were similar to the responses to BK. The RSNA response to Cap in the HF group was significantly increased (29.8 +/- 11.3 vs. 13.8 +/- 2.3% for 10 micrograms, P < 0.05 and 46.5 +/- 10.7 vs. 18.7 +/- 3.1% for 100 micrograms, P < 0.05). The cyclooxygenase blocker indomethacin (5 mg/kg i.v.) attenuated the reflex responses to BK in the HF group. These data suggest that the enhanced cardiac sympathetic afferent reflex to epicardial BK in HF appears to be mediated by altered levels of prostaglandin synthesis. Blockade of cardiac sympathetic afferents with topical lidocaine reduced baseline of RSNA significantly more in the HF state than in the normal state (-24.2 +/- 3.6 vs. -4.3 +/- 4.5%, P < 0.05). We conclude from these data that the cardiac sympathetic afferent reflex is sensitized in the HF state and speculate that this enhanced cardiac sympathetic afferent reflex may contribute to the sustained higher sympathetic tone in chronic HF.
<title>Multielement diffractive optical designs using evolutionary programming</title> (1995)

This paper describes techniques developed for the design of diffractive beam shaping elements for use with lasers. These techniques have been applied to systems containing both single and multiple cascaded DOEs. Past work by the authors and others described the use of genetic algorithms (GAs) for optimization of diffractive gratings. By appropriate choice of variable encoding and evaluation kernel, we were able to develop a modified genetic algorithm to optimize single diffractive optics for laser beam shaping. Genetic algorithms are a subset of a large class of evolution-based optimization and search algorithms. By developing specific software modules, we are able to apply a variety of evolutionary programming optimization algorithms to a number of design problems.
Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners (2001)

The hybridising potential of anhydrohexitol nucleoside analogues (HNAs) is well documented, but tedious synthesis of the monomers hampers their development. In a search for better analogues, the synthesis of two new methylated anhydrohexitol congeners 1 and 2 was accomplished and the physico-chemical properties of their respective oligomers were evaluated. Generally, oligonucleotides (ONs) containing the 3'-O-methyl derivative 1 showed a small increase in thermal stability towards complementary sequences as compared to HNA. Compared to the altritol modification, 3'-O-methylation seems to cause a small decrease in thermal stability of duplexes, especially when targeting RNA. These results suggest the possibility of derivatisation of the 3'-hydroxyl group of altritol-containing congeners without significantly affecting the thermal stability of the duplexes. The methyl glycosidic analogues 2 likewise increased the affinity for RNA in comparison with well-known HNA, while at the same time being economically more favorable monomers. However, homopolymers of 2 displayed self-pairing, but not so homopolymers of 1. Upon incorporation of the hexitols within RNA sequences in an effort to induce a beneficial pre-organised structure, the positive effect of the 3'-O-methyl derivative 1 proved larger than that of 2.
[Efficiency of enterosorbents and detoxication mechanisms in immature rats with simulated hepatitis]. (1992)

Different modifications of fibrous enterosorbent of the ACFM "Dnepr-MN" type exert a normalizing effect on the morphofunctional state of the liver of preadolescent rats with the model of toxic hepatitis. The distortion in the oxidation of lipids with peroxide and in the antioxidizing system protection removed, antitoxic liver function increases, which is confirmed by microsomal oxidation processes. A mediated effect of enterosorbents on the hepatocyte membrane structures is very significant for their detoxication effect.
CRITICAL SUCCESS FACTORS IN OUTSOURCING OF INFORMATIONTECHNOLOGY SERVICES: A STUDY WITH ENTERPRISES IN SAO PAULO, BRAZIL (2008)

The outsourcing of Information Technology (IT) services
					consist in significant subject as enterprise strategy. The focus of
					this study was the outsourcing of IT services, in three companies
					of Sao Paulo, Brazil, which holds contracts with suppliers/service
					providers. The exploratory research with qualitative method was
					performed with structured interviews, to the social subjects that
					occupy positions of management or direction in companies surveyed
					and participate in the process of outsourcing of IT service. The
					collected data were treated by the technique of content analysis.
					The research showed that the services contracted were Data Center,
					IT infrastructure, Network, etc. The main reasons why these
					companies outsource were search for reducing costs, optimizing
					solutions, improvement in quality, increase productivity and focus
					on the main business. The critical success factors were considered
					motivation and acceptance of outsourcing, and careful selection of
					the IT service providers.
Pitch Synchronous Analysis of Voiced Sounds (1961)

A study of vowel sounds by means of a spectral analysis keyed synchronously to the voice pitch has been carried out. Spectra are obtained by Fourier analysis of individual pitch periods which were established by visual inspection of oscillogram. A digital computer served as the analyzer. The spectra are represented by a pattern of zeros and poles obtained by a process of successive approximation, again carried out by computer. The contributions from vocal tract and glottal source can be uniquely separated and examined. These results show that vowel sounds can be represented by a sequence of poles arising from the vocal tract and a sequence of zeros character the izglottal excitation. The frequencies of the vocal tract poles agreed with previous measurements, but the damping factors were not entirely consistent with earlier estimates. The zeros showed approximately uniform frequency spacing, particularly at high frequencies. A theoretical development indicated that this characteristic was to be expected from the known structure of the glottal excitation. The zero pattern was used to estimate the ratio of open-to-closed time for the glottis during voicing.