gebhart/patrepeval huggingface dataset:
Abstract 5195: NBL-015, a next-generation fully human anti-claudin 18.2 antibody with enhanced ADCC and CDC for treating gastric and pancreatic cancers (2020)

Abstract Claudin 18.2 is a member of the claudin family and belongs to the class of tight junction proteins. Its expression on normal tissue is restricted to gastric cell lineage and on short-lived differentiated epithelial cells, while it is expressed in multiple cancer types, including pancreatic, stomach, esophageal, lung and ovarian cancers. The differential expression pattern of claudin18.2 between tumor and normal tissues makes it a promising drug target to treat those cancers, especially pancreatic and gastroesophageal tumors, which are among the malignancies with the highest unmet medical need. Zolbetuximab is a mouse-human chimeric antibody developed by Astellas Pharma. It exhibits encouraging clinical efficacy and good safety data in gastric patients with mid-high claudin18.2 expressing in their tumor tissues. However, claudin18.2 expression in the majority of tumors is moderate and heterogeneous. Expanding the therapeutic window and allowing the anti-cladudin18.2 drug to benefit patients with moderate to low claudin18.2 expression require the antibody to have a higher binding affinity and strong killing activity. NBL-015 is a fully human antibody generated from Tranni transgenic mouse and is predicted to bear with low development and immunogenicity risks. NBL-015 demonstrates high selectivity against claudin18.2, and it doesn't bind to the close splicing variant claudin18.1. It exhibits strong binding to multiple pancreatic and gastric tumor cell lines expressing moderate to low level of CLDN18.2 endogenously. Moreover, NBL-015 is Fc engineered to enhance both ADCC and CDC activities. It shows robust tumor-killing activity comparing with antibodies with wild type Fc and to the benchmark antibody in the ex vivo models. NBL-015 also demonstrates superior anti-tumor efficacy in multiple gastric and pancreatic tumor CDX models expressing moderate to low claudin18.2, and in PBMC humanized NOG mice bearing gastric and pancreatic CDX tumors. In conclusion, our data confirm the successful discovery and optimization of a next-generation anti-claudin18.2 mAb, NBL-015, using NovaRock's proprietary antibody discovery and development platforms. NBL-015 exhibits potent anti-tumor activity in vitro and in vivo. It is currently in process development and IND enabling studies. It is targeted to enter clinical studies in early 2021. Citation Format: Ming Lei, Anna Przybyla, Ahmed Hassan, Qingtai Su, Gabriela Hrebikova, Samantha Wallner, Danielle Lavery, Kevin Chen, Raymond Yu, Joshua Dewe, Samruddhi Patil, Haichun Huang, Yi Pei, Zhong Liu, Han Li. NBL-015, a next-generation fully human anti-claudin 18.2 antibody with enhanced ADCC and CDC for treating gastric and pancreatic cancers [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5195.
Integer programming based topology selection of cell-level analog circuits (1995)

A new approach to cell-level analog circuit synthesis is presented. This approach formulates analog synthesis as a Mixed-Integer Nonlinear Programming (MINLP) problem in order to allow simultaneous topology and parameter selection. Topology choices are represented as binary integer variables and design parameters (e.g., device sizes and bias voltages) as continuous variables. Examples using a Branch and Bound method to efficiently solve the MINLP problem for CMOS two-stage op amps are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comprehensive Design of Axisymmetric Wind Tunnel Contractions (1975)

Design charts for wind tunnel contractions are developed using an inviscid, incompressible flow analysis. A contour formed of two cubic arcs joined smoothly together was found to be a good choice for a wall shape. Therefore, it was selected as the basis for a one-parameter family of wall shapes, which was then investigated in detail. The design chart parameters are the maximum wall pressure coefficients at the inlet (as an indicator of the danger of separation at the inlet end) and at the exit (which is related to the exit velocity nonuniformity). For any choice of these two parameters the charts yield the shape parameter and the nozzle length for this particular family of shapes. The charts may be used to design nozzles with no local separation at the inlet, and with any desired exit velocity uniformity. When the two pressure coefficients are chosen so that separation at both ends is just avoided, the exit boundary layer thickness should be near its minimum.
A complete calibration procedure for time domain network analyzers (2003)

A complete calibration procedure for a fast sampling oscilloscope has been developed. This calibration makes it possible to use time-domain-reflected, time-domain-transmitted (TDR-TDT) systems at a quantitative level as a time-domain network analysis (TDNA) system. The data acquisition and calibration programs are implemented on a personal computer. All measurements are achieved in the time domain; the errors are corrected in the frequency domain, after Fourier transform. The bandwidth of the system extends from DC to 20 GHz. A whole calibration is achieved in a time comparable to LRL calibration on a classical network analyzer.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Recovery of ethanol from fermentation broths by catalytic conversion to gasoline (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRecovery of ethanol from fermentation broths by catalytic conversion to gasolineDavid R. Whitcraft, Xenophon E. Verykios, and Rajakkannu MutharasanCite this: Ind. Eng. Chem. Process Des. Dev. 1983, 22, 3, 452–457Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/i200022a019https://doi.org/10.1021/i200022a019research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Pharmacokinetics of sustained release theophylline in low and high multidose regimens. (1981)

1 The in vitro characteristics (dissolution rate) of a sustained release theophylline preparation (Theo-Dur were first measured in acid medium (pH = 1) for 2 h and after that in a phosphate buffer (pH = 6.8) for 6 h. 2 The tablets released more than 95% of the active ingredient within 5 h at a rate of approximately 11% of the dose per hour at pH = 1 and about 18% at pH = 6.8. 3 Dose dependency of the pharmacokinetics of theophylline was tested in seven healthy volunteers by giving them either 300 mg Theo-Dur or 900 mg Theo-Dur in two doses a day for 5 days in a cross over design. After the last tablet on day 6 the fall-off curve was followed in order to calculate the pharmacokinetic parameters. 4 Theophylline (300 mg) resulted on day 6 in a mean serum concentration of 4.4 +/- 0.8 microgram ml-1. The dose of 900 mg resulted in a proportional increase in the serum concentration. The result was 13.3 +/- 2.2 micrograms ml-1. 5 The T1/2 (300 mg) was 9.3 +/- 1.4 h and the T1/2 (900 mg) was 8.5 +/- 2.0 h. These values do not significantly differ (0.10 less than P less than 0.20). 6 It was concluded that theophylline exhibits the rules of linear pharmacokinetics when serum concentrations are in the therapeutic range.
.beta.-Halogenated-pyrrole porphyrins. Molecular structures of 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetramesitylporphyrin, nickel(II) 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetramesitylporphyrin, and nickel(II) 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.beta.-Halogenated-pyrrole porphyrins. Molecular structures of 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetramesitylporphyrin, nickel(II) 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetramesitylporphyrin, and nickel(II) 2,3,7,8,12,13,17,18-octabromo-5,10,15,20-tetrakis(pentafluorophenyl)porphyrinD. Mandon, P. Ochenbein, J. Fischer, R. Weiss, K. Jayaraj, R. N. Austin, A. Gold, P. S. White, O. Brigaud, and Cite this: Inorg. Chem. 1992, 31, 11, 2044–2049Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ic00037a012https://doi.org/10.1021/ic00037a012research-articleACS PublicationsRequest reuse permissionsArticle Views759Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Spread of ictal activity in focal epilepsy (2008)

The speed of propagation of ictal activity and the latencies until initial clinical seizure symptoms differ significantly depending on focus localization. Extended spread often occurred within the time window during which current detection systems operate. This suggests that inclusion criteria of patients suitable for testing the efficacy of detection-based seizure intervention strategies should be based on focus localization and patient-individual propagation patterns.
A 0.12-<formula formulatype="inline"><tex Notation="TeX">${\hbox{mm}}^{2} $</tex></formula> 2.4-GHz CMOS Inductorless High Isolation Subharmonic Mixer With Effective Current-Reuse Transconductance (2015)

In this work, the design of an inductorless, high-isolation, and high conversion gain fully differential subharmonic down-conversion mixer for 2.4-GHz wireless application is presented. A complementary current-reuse technique is adopted between the transconductance and the local oscillator (LO) switching stage to boost the conversion gain without additional power consumption in the concept of reusing the dc current of the LO switching stage. The LO switching transistors are driven by a 25% duty cycle input to further enhance the conversion gain and improve the noise-figure performance. An active balun is integrated in the design for single-balanced to differential conversion or vice-versa, along with an RC poly phase filter to generate quadrature LO signals from a differential input signal. The subharmonic mixer is fabricated in a 0.13- μm standard CMOS technology with a core chip dimension of 313 μm× 372 μm and a power consumption of 5.82 mW from a supply voltage of 1.2 V. Experimental results show a conversion gain of 13.61 dB, an input-referred third-order intercept point of -4.46 dBm, a noise figure of 20 dB, and an isolation greater than 50 dB between the LO, RF, and IF ports. The proposed inductorless subharmonic mixer has a competitive performance in size with high isolation performance and highest conversion gain in comparison to other published works.
Biological Roles and Functional Mechanisms of Arenavirus Z Protein in Viral Replication (2012)

Arenaviruses can cause severe hemorrhagic fever diseases in humans, with limited prophylactic or therapeutic measures. A small RING-domain viral protein Z has been shown to mediate the formation of virus-like particles and to inhibit viral RNA synthesis, although its biological roles in an infectious viral life cycle have not been directly addressed. By taking advantage of the available reverse genetics system for a model arenavirus, Pichinde virus (PICV), we provide the direct evidence for the essential biological roles of the Z protein's conserved residues, including the G2 myristylation site, the conserved C and H residues of RING domain, and the poorly characterized C-terminal L79 and P80 residues. Dicodon substitutions within the late (L) domain (PSAPPYEP) of the PICV Z protein, although producing viable mutant viruses, have significantly reduced virus growth, a finding suggestive of an important role for the intact L domain in viral replication. Further structure-function analyses of both PICV and Lassa fever virus Z proteins suggest that arenavirus Z proteins have similar molecular mechanisms in mediating their multiple functions, with some interesting variations, such as the role of the G2 residue in blocking viral RNA synthesis. In summary, our studies have characterized the biological roles of the Z protein in an infectious arenavirus system and have shed important light on the distinct functions of its domains in virus budding and viral RNA regulation, the knowledge of which may lead to the development of novel antiviral drugs.
Interference‐filter‐based stereoscopic 3D LCD (2010)

A novel stereo 3D LCD for passive interference filter glasses is presented.A demonstrator based on a standard 120Hz LCD was set up.Stereoscopic image separation was realized in a time-sequential mode using a LED-based scanning backlight with two complementary spectra.A stereo brightness of 3 cd/m and a channel separation of 30:1 were achieved.
Human Immunodeficiency Virus‐Associated Dementia: Review of Pathogenesis, Prophylaxis, and Treatment Studies of Zidovudine Therapy (1999)

Human immunodeficiency virus (HIV)-associated dementia (HIVD) has been reported in up to 15% of HIV-infected adult patients. Although the pathogenesis of HIVD remains unclear, HIV probably plays an important role in the syndrome, as evidenced by the correlation between cerebrospinal fluid (CSF) HIV load and neuropsychological functioning. Although a large number of antiretrovirals are used to treat HIVD, zidovudine is the best studied. Zidovudine therapy has been associated with reduced levels of HIV RNA in CSF, fewer HIV-related changes in brain tissue at autopsy, and time-limited improvements in neurological function among AIDS and HIVD patients. More recent studies have investigated the penetration into CSF of other antiretrovirals, including protease inhibitors, and the clinical efficacy of abacavir in the treatment of dementia. HIV encephalopathy may occur in 30%-60% of children with AIDS and causes significant disability. Zidovudine has been associated with improved neuropsychological functioning in children with progressive encephalopathy, but optimum dosing levels, duration of effect, and prophylactic potential remain to be demonstrated.
Simulation of Cumuliform Clouds Based on Computational Fluid Dynamics (2002)

Simulation of natural phenomena is one of the important research fields in computer graphics. In particular, clouds play an important role in creating images of outdoor scenes. Fluid simulation is effective in creating realistic clouds because clouds are the visualization of atmospheric fluid. In this paper, we propose a simulation technique, based on a numerical solution of the partial differential equation of the atmospheric fluid model, for creating animated cumulus and cumulonimbus clouds with features formed by turbulent vortices.
Removal of Acid Black 194 dye from water by electrocoagulation with aluminum anode (2016)

Application of an electrocoagulation process (EC) for the elimination of AB194 textile dye from synthetic and textile wastewater (effluent) contaminated with AB194 dye, was carried out using aluminum anodes at two different initial pH values. Tafel studies in the presence and absence of the dye were performed. The aluminum species formed during the electrolysis were quantified by atomic absorption, and the flocs formed in the process were analyzed by HPLC-MS. Complete removal of AB194 from 1.0 L of solution was achieved applying low densities current at initial pH values of 4.0 and 8.0. The removal of AB194 by EC was possible with a short electrolysis time, removing practically 100% of the total organic carbon content and chemical oxygen demand. The final result was completely discolored water lacking dye and organic matter. An effluent contaminated with 126 mg L(-1) AB194 dye from a Chilean textile industry was also treated by EC under optimized experimental conditions, yielding discolored water and considerably decreasing the presence of organic compounds (dye + dyeing additives), with very low concentrations of dissolved Al(3+). Analysis of flocs showed the presence of the original dye without changes in its chemical structure.
Music and Poetry (1968)

Music is opaque as an art and discussed briefly is the effect this opaqueness has on any discussion of the relation between music and poetry. Music seems self-sufficient and words become merely vocables needed for a voice to produce sounds.
NOx Destruction Behavior of Select Materials When Combined with a Non-Thermal Plasma (1999)

<div class="htmlview paragraph">NO<sub>x</sub> reduction efficiency under simulated lean burn conditions is examined for a non-thermal plasma in combination with borosilicate glass, alumina, titania, Cu-ZSM-5 and Na-ZSM-5. The non-thermal plasma alone or with a packed bed of borosilicate glass beads converts NO to NO<sub>2</sub> and partially oxidizes hydrocarbons. Alumina and Na-ZSM-5 reduce a maximum of 40% and 50% of NO<sub>x</sub> respectively; however, the energy cost is high for Na- ZSM-5. Cu-ZSM-5 converts less than 20% with a very high energy consumption. The anatase form of titania reduces up to 35% of NOx at a relatively high energy consumption (150J/L) when the catalyst is contained in the plasma region, but does not show any appreciable conversion when placed downstream from the reactor. This phenomenon is explained by photo-activation of anatase in the plasma.</div>
Interoperability among access control models (2012)

In the era of distributed computing and multi-user environment, federated organizations need to collaborate and access each other's resources. In order to access resources user must be authenticated seamlessly and authorized to perform access request. Existing centralized solution such as Single Sign On suffers with single point of failure. In our research, we propose a distributed solution by making access control models, existing in different organizations, interoperable. We show how decentralized and distributed yet federated organizations with heterogeneous access control models can share valuable resources/services in secure, reliable and efficient manner with no or minimal changes to their existing infrastructure. Our solution converts the existing policies of collaborating organization into ABAC model by a model transformation utility. Any cross organization transactions are handled by our plug-in based system without requiring any changes in the current authentication and authorization workflow of both collaborating parties.
Monitoring of egg shell strength and egg shell breakage in different production chains of consumption eggs. (2005)

In consumption eggs the quality of the shell is of major importance. Therefore it is of great interest to obtain high shell strength in order to resist all impacts an egg is subjected to in the production chain. The research had 3 goals: 1. monitoring of the critical points for eggshell breakage in different logistic chains; 2. investigate differences in eggshell strength (Kdyn & damping) between eggs produced in different housing systems; 3. developing a model to investigate the relation between the initial shell strength (Kdyn & damping), and the likelihood of the egg to break during handling and grading. Four logistic chains were investigated: cages, furnished cages, aviary and free-range system. In all systems Bovans Goldline © chickens in their mid lay were housed. In every system, a randomised set of 1500 eggs was taken, numbered and strength of the intact eggs was measured. In this way the percentage of broken eggs directly after laying was defined. Then all the intact eggs were placed back into the cages and they continued their normal way throughout the logistic chain. At every critical point in the logistic chain, the eggs were examined for breakage to define the percentage of breakage. Firstly the traditional and furnished cage system showed high breakage directly after lay (6.73% resp. 10.72%) while the other systems showed about 2% of breakage. There was no difference in breakage between the other control points of the logistic chains. Secondly, there was a significant difference between the eggshell strength of eggs from chickens in different housing systems. Thirdly, there was a significant correlation between the measured shell strength and the likelihood of breakage. In conclusion, it was shown that measurement of Kdyn and damping provides a good predictive value for egg shell breakage.
A new relaxation algorithm and passive sensor data association (1992)

The static problem of associating measurements at a given time from three angle-only sensors in the presence of clutter, missed detections, and an unknown number of targets is addressed. The measurement-target association problem is formulated as one of maximizing the joint likelihood function of the measurement partition. Mathematically, this formulation leads to a generalization of the 3-D assignment (matching) problem, which is known to be NP hard. The solution to the optimization problem developed is a Lagrangian relaxation technique that successively solves a series of generalized two-dimensional (2-D) assignment problems. The algorithm is illustrated by several application examples.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
“Folk” (1879)

Journal Article “Folk” Get access W. P. A. W. P. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s5-XII, Issue 299, 20 September 1879, Page 234, https://doi.org/10.1093/nq/s5-XII.299.234b Published: 20 September 1879