gebhart/patrepeval huggingface dataset:
Interaction of C-terminal sequences of human immunodeficiency virus reverse transcriptase with template primer. (1991)

We have raised a rabbit monospecific antibody (designated C2003) against a synthetic peptide (CTP66) derived from a conserved sequence in the C-terminal portion of the p66 component of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) (DeVico, A.L., Copeland, T.D., Veronese, F.D., Oroszlan, S., Gallo, R. C., and Sarngadharan, M. G. (1989) AIDS Res. Hum. Retroviruses 5, 51-60). This antibody directly inhibits the polymerase activity of HIV-1 RT and of RTs from a variety of retroviruses. HIV-1 RT is protected from this inhibition by preincubation of the enzyme with template primer prior to treatment with the antibody. Such protection is abrogated when the pretreatment is conducted under conditions of high ionic strength. Kinetic studies showed that the antibody-mediated inhibition is competitive with respect to template primer concentration. These results indicate that C2003 antibody acts to interfere with the template binding function of the enzyme and further indicates that conserved residues recognized by the antibody may be directly involved in this function.
A Hybrid Walsh Transform Computer (1973)

A hybrid special-purpose computer based on a recursive algorithm for discrete Walsh transform computations is described. The device uses feedback in time to reduce the required number of summing junctions to N, the number of data points to be transformed. Computations are completed in 700 μs when N = 256.
University Students' Awareness of Radiation (2012)

After Fukushima Nuclear Accident on Mar11, 2011, to grasp the thought of university students in Korea on radiation and medical radiation and seek for the right mass communication on the radiation safety of the people and the proper teaching method on radiation, 790 questionnaires from the universities which had a four-year department of radiological science in 5 provinces(Gyeonggi, Gangwon, Chungcheong, Jeolla, and Gyeongsang-do) all over the country were collected and analyzed. The questionnaire was composed of 36 items, and it was analyzed that one of the important causes that made them feel that radiation was dangerous was 'even if they were exposed to the small quantity of radiation, they could have trouble later.' (). In the item of the control of radiation, there were the respondents who answered that the government should take action rather than an individual(). In the item of 'Fukushima Nuclear Accident made me think that 'We should not keep nuclear power generation', the result was . In the item of 'My thought on the medical radiation has negatively changed since Fukushima Nuclear Accident', the students who hadn't taken the course related with radiation showed a negative thought on the medical radiation, such as, there was as a whole, in department of radiological science, in department of dental hygiene, and in other departments. And also, those who thought that the education of radiation was necessary were 82.28%, and T.V or Internet was thought as the most effective teaching method.
Determination and analysis of cordycepin and adenosine in the products of Cordyceps spp. (2009)

Cordyceps sinensisis, a kind of precious natural crude drugs and edible mushrooms, were used as tonic food in East Asia area and enjoyed an extensive praise for its medicinal functions. Cordyceps militaris, as a substitute for C. sinensis, is a widely distributed species, which can be cultivated in various medium. In this study, the contents of major bioactive components, cordycepin and adenosine in fruiting bodies and mycelia from the nature C. sinensis and artificial cultural C. militaris were investigated using improved HPLC method. The results showed the mean contents of cordycepin and adenosine in the fruiting bodies of C. militaris were 2.654 ± 0.02 and 2.45 ± 0.03 mg/g, those in C. sinensis were 0.9801 ± 0.01 and 1.643 ± 0.03 mg/g, while those in the mycelium of C. militaris were 0.9040 ± 0.02 and 1.592 ± 0.03 mg/g, respectively. The concentration of cordycepin and adenosine in the fruiting bodies of C. militaris were higher than that in natural C. sinensis, while the fermented mycelium of C. militaris were similar with natural C. sinensis.
Anti-wear properties of Cr–C and Ni–Co alloy coatings as substitutes for conventional nanocrystalline Cr coatings (2008)

Nanocrystalline Ni–Co, amorphous Cr–C alloy and nanocrystalline Cr–C coatings were electrodeposited from 'environmentally acceptable' electrolytes as potential substitutes for conventional nanocrystalline Cr coatings electrodeposited from noxious hexavalent chromium. The structure, morphology and hardness of coatings are investigated using a transmission electron microscope, a scanning electronic microscope and a Vickers hardness tester, respectively. Anti-wear properties are tested on a pin-on-plate vibrant wear tester. The correlation between the wear resistance, hardness, brittleness and the lubricated state is investigated. The results show that the wear behaviour of specimens significantly depends on their lubricated state, hardness and brittleness. Under the lubricated sliding condition, abrasive wear is the primary wear mechanism for all specimens. With respect to the abrasive wear mechanism, both the elastic and plastic deformations play important roles during the lubricated sliding process. Thus, the amorphous and nanocrystalline Cr–C alloy coatings, with both high brittleness and high hardness, exhibit a lower wear rate than the conventional Cr and Ni–Co coatings. On the other hand, under the dry sliding condition, the annealed Ni–Co coating, with an excellent compromise between high hardness and toughness, exhibits an abrasive wear mechanism and a relatively low wear rate; in contrast, the brittle Cr-matrix coatings exhibit a severe fatigue/delamination wear mechanism and high wear rate.
Breast Cancer Diagnosis Using a Microfluidic Multiplexed Immunohistochemistry Platform (2010)

The microfluidic system, for the first time, was successfully applied to human clinical tissue samples and histopathological diagnosis was realized for breast cancers. Our results showing substantial agreement indicate that several cancer-related proteins can be simultaneously investigated on a single tumor section, giving clear advantages and technical advances over standard immunohistochemical method. This novel concept will enable histopathological diagnosis using numerous specific biomarkers at a time even for small-sized specimens, thus facilitating the individualization of cancer therapy.
A large scale, homogeneous, fully distributed parallel machine, I (1977)

The preliminary hardware description of CHOPP (Columbia Homogeneous Parallel Processor), a MIMD machine supporting a fully distributed host-less operating system is presented. The architecture is intended to permit implementation of machines with 105 to 106 processors. Issues of interconnection networks, throughput, and memory structure are treated.
Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from<i>Diospyros leucomelas</i>* (1995)

Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.
High Dynamic Range image tone mapping based on local Histogram Equalization (2010)

High Dynamic Range (HDR) images can represent the acquired scene with a greater dynamic range of luminance than classical Low Dynamic Range (LDR) ones. Despite the recent diffusion of some HDR camera models, HDR displays are not yet in the market. For this reason HDR images need to be adapted in order to be properly rendered through conventional devices. This operation mainly consists in a dynamic range compression realized by applying a Tone Mapping Operator (TMO). In this work, a new tone map algorithm, derived from the Contrast Limited Adaptive Histogram Equalization (CLAHE) technique, is presented. With respect to the original CLAHE, in the proposed implementation an adaptive contrast limit and a new strategy for the determination of local tone mapping functions have been introduced. The comparison between the obtained LDR images, and those produced by applying State of the Art TMOs, evidences how the main characteristic of the proposed algorithm is the ability to equally enhance visibility in both dark and bright areas. This could be, for example, a key feature in video surveillance applications and automotive safety camera systems.
Property‐morphology relationships of polymethylmethacrylate/polyvinylidenefluoride blends (1982)

Abstract An investigation was conducted to establish property‐morphology relationships in polymethylmethacrylate/polyvinylidenefluoride (PMMA/PVDF) blends. All blends were compounded in a twin‐screw extruder and then processed by injection molding Mechanical properties of blends of various compositions were studied by dynamic mechanical and impact strength measurements. The presence of crystalline regions in blends was determined by Differential Scanning Calorimetry (DSC). Morphology of fracture surfaces of blends was studied by Spinning Electron Microscopy (SEM). PMMA/PVDF blends were found to form compatible mixtures over a wide range of blend composition. Changes in dynamic mechanical properties upon annealing were found to be a direct function of blond morphology. Electron microscopic evidence showed no signs of phase separation. DSC measurements detected crystalline regions in all blends containing 40 percent or more (by weight) PVDF.
Chelation in Nutrition, Metal Chelates in Plant Nutrition (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChelation in Nutrition, Metal Chelates in Plant NutritionE. J. HaertlCite this: J. Agric. Food Chem. 1963, 11, 2, 108–111Publication Date (Print):March 1, 1963Publication History Published online1 May 2002Published inissue 1 March 1963https://pubs.acs.org/doi/10.1021/jf60126a003https://doi.org/10.1021/jf60126a003research-articleACS PublicationsRequest reuse permissionsArticle Views295Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
외부설비의 이용을 고려한 최적 설비용량 결정 (2012)

The demand for facility is changed dynamically for discrete and finite time periods. The holding cost for excess facility is needed for periods that the facility capacity is greater than the demand for the facility, and the usage cost of the outside facility for shortage facility is needed for periods that the demand for facility is greater than the facility capacity. This paper addresses to determine the facility capacity of minimizing the sum of the facility capacity cost, the holding cost of the excess facility and the usage cost of the outside facility. The problem is analyzed. The characteristics of the optimal solution are analyzed, and a algorithm is developed. A numerical example is shown to explain the problem.
Characterization and implementation of self-aligned TiSi/sub 2/ in submicrometer CMOS technology (1991)

Characterization and process implementation of a self-aligned TiSi/sub 2/ in a submicrometer CMOS process are presented. The effects of different in situ sputter etch configurations prior to Ti deposition on silicidation is discussed. It is shown that bridging is not only first RTP time- and temperature-dependent, but also dependent on the Ti(N) overetch time. The C49 to C54-TiSi/sub 2/ phase transformation is found to be dependent on both the C49-TiSi/sub 2/ film thickness and the linewidth. A potential degradation phenomenon with high-temperature back-end processing is discussed, and the impact of TiSi/sub 2/ on specific contact resistance and circuit performance is presented. Thin film analysis was done by Auger electron spectrometry, Rutherford backscattering spectrometry with 2-MeV He/sup +/, transmission electron microscopy, secondary ion mass spectrometry, X-ray diffraction, and X-ray fluorescence spectrometry. Sheet resistance measurements were carried out with a four-point probe.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Approaches to identify and develop Web services as instance of SOA architecture (2005)

Web services underlying technologies and standards allow interfacing, publishing, and binding services available on the Web and accessible through protocols based on the Internet. Moreover, Web services can easily live with distributed object computing middleware such as CORBA, DCOM and EJB, and integrated with semantic Web to overcome their limitations. These capabilities allow composition of business processes that cross the boundaries of an organization into new business solutions and ultimately e-business. Yet, Web services deployment is still hindered by technical and especially methodological issues. This paper concerns with approaches to develop Web services, namely their identification, design, deployment, and management. The paper presents a comparative study of two perspectives of developing Web services: IT-oriented and business-oriented perspectives with respect to: (1) developing process, (2) used building blocks, (3) categories of Web services, and (4) wrapping of legacy applications. This comparative study aims at integrating both perspectives into a multiple abstraction level architecture with respect to a business model, where higher abstract levels deal with business-orientation, whereas the lower levels concern with IT.
Otx2 Promotes the Survival of Damaged Adult Retinal Ganglion Cells and Protects against Excitotoxic Loss of Visual Acuity<i>In Vivo</i> (2011)

Retinal ganglion cells (RGCs) are the projection neurons from the eye to the brain and their loss results in visual impairment in a number of diseases. Transcription factors with a homeodomain can translocate between cells and, in at least one reported case, can stimulate neuronal survival. Otx2 is a homeoprotein transcription factor expressed in the retina that is taken up by RGCs. We thus hypothesized that Otx2 capture could regulate the survival of adult RGCs. We report that Otx2 stimulates the survival of adult mouse and rat RGCs in vitro and protects RGCs against NMDA-induced toxicity in vivo in mice. In the latter model, Otx2 also preserves visual acuity.
Statistical Study of Thermal Fracture of Ceramic Materials in the Water Quench Test (1987)

The Weibull statistical theory of fracture was applied to thermal shock of ceramics in the water quench test. Transient thermal stresses and probability of failure were calculated for a cylindrical specimen cooled by convection. The convective heat transfer coefficient was calibrated using the time to failure which was measured with an acoustic emission technique. Theoretical failure probability distributions as a function of time and quench temperature compare favorably with experimental results for three high‐alumina ceramics and a glass.
RIP1-mediated AIP1 Phosphorylation at a 14-3-3-binding Site Is Critical for Tumor Necrosis Factor-induced ASK1-JNK/p38 Activation (2007)

Previously, we have shown that ASK1-interacting protein 1 (AIP1, also known as DAB2IP), a novel member of the Ras-GAP (Ras-GTPase-activating protein) protein family, opens its conformation in response to tumor necrosis factor (TNF), allowing it to form a complex with TRAF2-ASK1 that leads to activation of ASK1-JNK/p38 signaling in endothelial cells (EC). In the present study, we show that a TNF-inducible 14-3-3-binding site on AIP1 is critical for the opening of its conformation and for the AIP1-mediated TNF signaling. Ser-604, located in the C-terminal domain of AIP1, was identified as a 14-3-3-binding site. TNF treatment of EC induces phosphorylation of AIP1 at Ser-604 as detected by a phospho-specific antibody, with a similar kinetics to ASK1-JNK/p38 activation. 14-3-3 associates with an open, active state of AIP1 assessed by an in vitro pulldown assay. Mutation of AIP1 at Ser-604 (AIP1-S604A) blocks TNF-induced complex formation of AIP1 with 14-3-3. TNF treatment normally induces association of AIP1 with TRAF2-ASK1. The interactions with TRAF2 and ASK1 do not occur with AIP1-S604A, suggesting that phosphorylation at this site not only creates a 14-3-3-binding site but also opens up AIP1, allowing binding to TRAF2 and ASK1. Overexpression of AIP1-S604A blocks TNF-induced ASK1-JNK activation. We further show that RIP1 (the Ser/Thr protein kinase receptor-interacting protein) associates with the GAP domain of AIP1 and mediates TNF-induced AIP1 phosphorylation at Ser-604 and JNK/p38 activation as demonstrated by both overexpression and small interfering RNA knockdown of RIP1 in EC. Furthermore, RIP1 synergizes with AIP1 (but not AIP1-S604A) in inducing both JNK/p38 activation and EC apoptosis. Our results demonstrate that RIP1-mediated AIP1 phosphorylation at the 14-3-3-binding site Ser-604 is essential for TNF-induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling.
High-mobility poly-Si thin-film transistors fabricated by a novel excimer laser crystallization method (1993)

High-mobility poly-Si thin-film transistors (TFTs) were fabricated by a novel excimer laser crystallization method based on dual-beam irradiation. The new method can reduce the solidification velocity of the top Si layer by heating the bottom Si layer of the Si/SiO/sub 2//Si/glass substrate structure by means of laser irradiation not only from the front side but also from the back side. The grain size of poly-Si film was enlarged up to 2 mu m. The field-effect mobilities of the TFT exceeded 380 cm/sup 2//V-s for electrons and 100 cm/sup 2//V-s for holes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A probabilistic model based approach for blended search (2009)

In this paper, we propose to model the blended search problem by assuming conditional dependencies among queries, VSEs and search results. The probability distributions of this model are learned from search engine query log through unigram language model. Our experimental exploration shows that, (1) a large number of queries in generic Web search have vertical search intentions; and (2) our proposed algorithm can effectively blend vertical search results into generic Web search, which can improve the Mean Average Precision (MAP) by as much as 16% compared to traditional Web search without blending.
Integrating Hospital Administrative Data to Improve Health Care Efficiency and Outcomes: “The Socrates Story” (2013)

Evaluation of health care outcomes has become increasingly important as we strive to improve quality and efficiency while controlling cost. Many groups feel that analysis of large datasets will be useful in optimizing resource utilization; however, the ideal blend of clinical and administrative data points has not been developed. Hospitals and health care systems have several tools to measure cost and resource utilization, but the data are often housed in disparate systems that are not integrated and do not permit multisystem analysis. Systems Outcomes and Clinical Resources AdministraTive Efficiency Software (SOCRATES) is a novel data merging, warehousing, analysis, and reporting technology, which brings together disparate hospital administrative systems generating automated or customizable risk-adjusted reports. Used in combination with standardized enhanced care pathways, SOCRATES offers a mechanism to improve the quality and efficiency of care, with the ability to measure real-time changes in outcomes.
Stereoselective synthesis of 2β‐carbomethoxy‐3β‐phenyltropane derivatives. Enhanced stereoselectivity observed for the conjugate addition reaction of phenylmagnesium bromide derivatives with anhydro dichloromethane (1996)

Abstract The use of dichloromethane as a solvent for the conjugate addition reaction of preformed etheral solutions of phenylmagnesium bromide derivatives with anhydroecgonine methyl ester ( 2 ) was found to enhance the stereoselectivity of the reaction and provide the 2β‐carbomethoxy‐3β‐phenyltropane derivatives 3a‐d in high yield.
Molecular Mechanisms and Regulation of K<sup>+</sup> Transport in Higher Plants (2003)

Potassium (K+) plays a number of important roles in plant growth and development. Over the past few years, molecular approaches associated with electrophysiological analyses have greatly advanced our understanding of K+ transport in plants. A large number of genes encoding K+ transport systems have been identified, revealing a high level of complexity. Characterization of some transport systems is providing exciting information at the molecular level on functions such as root K+ uptake and secretion into the xylem sap, K+ transport in guard cells, or K+ influx into growing pollen tubes. In this review, we take stock of this recent molecular information. The main families of plant K+ transport systems (Shaker and KCO channels, KUP/HAK/KT and HKT transporters) are described, along with molecular data on how these systems are regulated. Finally, we discuss a few physiological questions on which molecular studies have shed new light.
IMD—Software for modeling the optical properties of multilayer films (1998)

A computer program called IMD is described. IMD is used for modeling the optical properties (reflectance, transmittance, electric-field intensities, etc.) of multilayer films, i.e., films consisting of any number of layers of any thickness. IMD includes a full graphical user interface and affords modeling with up to eight simultaneous independent variables, as well as parameter estimation (including confidence interval generation) using nonlinear, least-squares curve fitting to user-supplied experimental optical data. The computation methods and user interface are described, and numerous examples are presented that illustrate some of IMD’s unique modeling, fitting, and visualization capabilities. © 1998 American Institute of Physics.