gebhart/patrepeval huggingface dataset:
A Clinical Trial of Progesterone for Severe Traumatic Brain Injury (2014)

Primary and secondary efficacy analyses showed no clinical benefit of progesterone in patients with severe TBI. These data stand in contrast to the robust preclinical data and results of early single-center trials that provided the impetus to initiate phase 3 trials. (Funded by BHR Pharma; SYNAPSE ClinicalTrials.gov number, NCT01143064.).
Resolution Enhancement in Multi-Image Stereo (2010)

Under stereo settings, the twin problems of image superresolution (SR) and high-resolution (HR) depth estimation are intertwined. The subpixel registration information required for image superresolution is tightly coupled to the 3D structure. The effects of parallax and pixel averaging (inherent in the downsampling process) preclude a priori estimation of pixel motion for superresolution. These factors also compound the correspondence problem at low resolution (LR), which in turn affects the quality of the LR depth estimates. In this paper, we propose an integrated approach to estimate the HR depth and the SR image from multiple LR stereo observations. Our results demonstrate the efficacy of the proposed method in not only being able to bring out image details but also in enhancing the HR depth over its LR counterpart.
Pancreolauryl and NBT-PABA tests. Are serum tests more practicable alternatives to urine tests in the diagnosis of exocrine pancreatic insufficiency? (1986)

Serum fluorescein and p-aminobenzoic acid were measured during a urine pancreolauryl and an N-benzoyl-l-tyrosyl-p-aminobenzoic acid (NBT-PABA) test in 22 healthy controls, 17 patients with gastrointestinal nonpancreatic diseases (normal secretin-pancreozymin test), and 31 patients with abnormal exocrine pancreatic function due to chronic pancreatitis. The optimal cutoff point for separating normal from abnormal pancreatic function was after 210 min in the pancreolauryl test and after 150 min in the NBT-PABA test. The latter test was slightly less sensitive and specific than the pancreolauryl test. Serum tests seem to offer a practicable alternative to the established indirect pancreatic function tests in urine and may be used in the elderly and severely ill, as well as in outpatients in whom correct collection of the urine may be difficult.
狮子·女巫·魔衣橱 (2010)

“这个衣橱多大啊!”露茜一边暗自想，一边又继续往前走。她不时拨开交迭着的柔软的皮衣，为自己开路。这时，她感到脚底下有什么东西在“嘎吱嘎吱”作响。“我难道踩着了樟脑丸了？”她想，一边蹲下身来用手去摸。
Thioflavine T interaction with synthetic Alzheimer's disease <i>β</i>‐amyloid peptides: Detection of amyloid aggregation in solution (1993)

Thioflavine T (ThT) associates rapidly with aggregated fibrils of the synthetic beta/A4-derived peptides beta(1-28) and beta(1-40), giving rise to a new excitation (ex) (absorption) maximum at 450 nm and enhanced emission (em) at 482 nm, as opposed to the 385 nm (ex) and 445 nm (em) of the free dye. This change is dependent on the aggregated state as monomeric or dimeric peptides do not react, and guanidine dissociation of aggregates destroys the signal. There was no effect of high salt concentrations. Binding to the beta(1-40) is of lower affinity, Kd 2 microM, while it saturates with a Kd of 0.54 microM for beta(1-28). Insulin fibrils converted to a beta-sheet conformation fluoresce intensely with ThT. A variety of polyhydroxy, polyanionic, or polycationic materials fail to interact or impede interaction with the amyloid peptides. This fluorometric technique should allow the kinetic elucidation of the amyloid fibril assembly process as well as the testing of agents that might modulate their assembly or disassembly.
Communicating Secret Information without Secret Messages in Wireless Sensor Networks (2015)

The problem of security in a sensor network has been researched mainly with methods derived from classical cryptography. With the advance of quantum computation and quantum cryptography, the problem of securing a sensor network with quantum means is immediate. The present paper adapts an existing quantum security protocol [1] to sensor networks. The contribution of the protocol is that it shares a secret message between two nodes of the sensor network, without showing in the environment any information about the content of the message. The information visible to other nodes and to the environment refers to array indices and to the reading strategy, but not to the values read. As each piece of secret information has a distinct public encoding, the protocol is equivalent to a one-time pad protocol. To exploit quantum properties, sensor nodes are endowed with coherent qubits, that can be read and set within the node. Additionally, there exists a central authority that manages the identity of the nodes and can perform quantum entanglement swapping.
Role of the hyperpolarization‐activated current <i>I</i><sub>h</sub> in somatosensory neurons (2008)

The hyperpolarization-activated current (I(h)) is an inward current activated by hyperpolarization from the resting potential and is an important modulator of action potential firing frequency in many excitable cells. Four hyperpolarization-activated, cyclic nucleotide-modulated subunits, HCN1-4, can form I(h) ion channels. In the present study we investigated the function of I(h) in primary somatosensory neurons. Neuronal firing in response to current injection was promoted by elevating intracellular cAMP levels and inhibited by blockers of I(h), suggesting that I(h) plays a critical role in modulating firing frequency. The properties of I(h) in three size classes of sensory neurons were next investigated. In large neurons I(h) was fast activating and insensitive to elevations in cAMP, consistent with expression of HCN1. I(h) was ablated in most large neurons in HCN1(-/-) mice. In small neurons a slower activating, cAMP-sensitive I(h) was observed, as expected for expression of HCN2 and/or HCN4. Consistent with this, I(h) in small neurons was unchanged in HCN1(-/-) mice. In a neuropathic pain model HCN1(-/-) mice exhibited substantially less cold allodynia than wild-type littermates, suggesting an important role for HCN1 in neuropathic pain. This work shows that I(h) is an important modulator of action potential generation in somatosensory neurons.
RRAM-Based Analog Approximate Computing (2015)

Approximate computing is a promising design paradigm for better performance and power efficiency. In this paper, we propose a power efficient framework for analog approximate computing with the emerging metal-oxide resistive switching random-access memory (RRAM) devices. A programmable RRAM-based approximate computing unit (RRAM-ACU) is introduced first to accelerate approximated computation, and an approximate computing framework with scalability is then proposed on top of the RRAM-ACU. In order to program the RRAM-ACU efficiently, we also present a detailed configuration flow, which includes a customized approximator training scheme, an approximator-parameter-to-RRAM-state mapping algorithm, and an RRAM state tuning scheme. Finally, the proposed RRAM-based computing framework is modeled at system level. A predictive compact model is developed to estimate the configuration overhead of RRAM-ACU and help explore the application scenarios of RRAM-based analog approximate computing. The simulation results on a set of diverse benchmarks demonstrate that, compared with a x86-64 CPU at 2 GHz, the RRAM-ACU is able to achieve 4.06-196.41× speedup and power efficiency of 24.59-567.98 GFLOPS/W with quality loss of 8.72% on average. And the implementation of hierarchical model and X application demonstrates that the proposed RRAM-based approximate computing framework can achieve 12.8× power efficiency than its pure digital implementation counterparts (CPU, graphics processing unit, and field- programmable gate arrays).
Assessing attention-deficit/hyperactivity disorder in adults: focus on rating scales. (2004)

The diagnosis of attention-deficit/hyperactivity disorder (ADHD) in adults can be a challenging process because it includes making judgments based on clinical interviews, rating scale results, informant ratings, and objective supporting evidence. The patient evaluation should gather information on the severity and frequency of symptoms, the establishment of childhood onset of symptoms, the chronicity and pervasiveness of symptoms, and the impact of symptoms on major life activities. Some of the rating scales being used in the adult population are the Conners' Adult ADHD Rating Scales, the Brown Attention-Deficit Disorder Scale for Adults, the Wender Utah Rating Scale, the ADHD Rating Scale and ADHD Rating Scale-IV, the Current Symptoms Scale, and the recently-developed Adult ADHD Self-Report Scale-v1.1 Symptom Checklist. More research is needed to establish the usefulness of self-administered rating scales compared with investigator-administered scales in the assessment and diagnosis of adult ADHD.
Pulse operation and threshold characteristics of 1.55-μm InAlGaAs-InAlAs VCSELs (2000)

All-monolithic air-post index-guided vertical-cavity surface-emitting lasers have been demonstrated under pulsed electrical injection at room temperature. The structure grown in single step by metal-organic chemical vapor deposition employs InP lattice matched InAlAs/InAlGaAs Bragg mirrors and a 2/spl lambda/-thick periodic gain active region with 15 InGaAs quantum wells (QWs). We report threshold current characteristics of these devices grown on a 2-in wafer with wide emission wavelength range of 1.51/spl sim/1.59 μm. For the devices larger than 30-μm in diameter, we found the minimum threshold current density of /spl sim/2.93 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at the emission wavelength of 1.57 μm, corresponding to about 20 nm wavelength offset between photoluminescence peak of InGaAs QWs and resonant cavity wavelength.
Agonistic and Antagonistic Activities of Neuromedin U-8 Analogs Substituted with Glycine or D-Amino Acid on Contractile Activity of Chicken Crop Smooth Muscle Preparations. (1991)

To study the structure-activity relationships of neuromedin U-8 (NMU-8) (H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2) and to develop a NMU-8 antagonist, twenty-three NMU-8 analogs substituted with Gly or the corresponding D-amino acid(s) at positions 1-8 were synthesized by solid-phase techniques. On isolated chicken crop preparations, the contractile activity of the synthetic NMU-8 analogs was compared with that of NMU-8 and their antagonistic activity was assayed against NMU-8. The replacement of Phe2, Phe4, Arg5, Pro6, Arg7 or Asn8 with Gly brought about a drastic decrease of the agonistic activities. Substitution of the corresponding D-amino acid residue for Phe2, Phe4, Arg5, Pro6 or Asn8 caused a marked decrease of the agonistic activities, while the replacement of Tyr1 with D-form enhanced the activity. It was further revealed that [D-Pro6]-NMU-8 and [D-Leu3, D-Pro6]-NMU-8 exerted a non-competitive antagonistic activity against NMU-8 with x values of 5.22 +/- 0.12 and 5.34 +/- 0.09, respectively. [D-Phe2, D-Pro6]-NMU-8, [D-Arg5, D-Pro6]-NMU-8 and [D-Pro6, D-Asn8]-NMU-8 showed a very weak antagonism. The results indicated that 1) the side chain of each amino acid at positions 2, 4, 5, 6, 7 and 8 of NMU-8 is of relative importance for the expression of the contractile activity, and 2) [D-Pro6]-NMU-8 and its four analogs acted as an antagonist against NMU-8.
The Color Loci of Mice – A Genetic Century (2003)

Color loci in mammals are those genetic loci in which mutations can affect pigmentation of the hair, skin, and/or eyes. In the mouse, over 800 phenotypic alleles are now known, at 127 identified color loci. As the number of color loci passed 100 only recently, we celebrate this 'century' with an overview of these loci, especially the 59 that have been cloned and sequenced. These fall into a number of functional groups representing melanocyte development and differentiation, melanosomal components, organelle biogenesis, organelle transport, control of pigment-type switching, and some systemic effects. A human ortholog has been identified in all cases, and the majority of these human genes are found to be loci for human disorders, often affecting other body systems as well as pigmentation. We expect that a significant number of color loci remain to be identified. Nonetheless, the large number known already provide a treasury of resources for reconstruction of the mechanisms, at the subcellular, cellular and tissue levels, that produce a functional pigmentary system and contribute to the normal development and functioning of many other organ systems. The mutant mice also provide valuable models for the study of human disease.
Introducing A Platform For Encryption Algorithms (2008)

In this paper, we introduce a novel platform encryption method, which modify its keys and random number generators step by step during encryption algorithms. According to complexity of the proposed algorithm, it was safer than any other method.
Zanthoxylum alatum extract inhibits skin sensitivity. (2002)

A lipophilic extract from the fruits of the Chinese plant Zanthoxylum alatum Roxb can be diluted with oleyl alcohol to yield a cosmetic ingredient that soothes sensitire skin.
Stringent Requirement for the C Protein of Wild-Type Measles Virus for Growth both In Vitro and in Macaques (2005)

The P gene of measles virus (MV) encodes the P protein and three accessory proteins (C, V, and R). However, the role of these accessory proteins in the natural course of MV infection remains unclear. For this study, we generated a recombinant wild-type MV lacking the C protein, called wtMV(C-), by using a reverse genetics system (M. Takeda, K. Takeuchi, N. Miyajima, F. Kobune, Y. Ami, N. Nagata, Y. Suzaki, Y. Nagai, and M. Tashiro, J. Virol. 74:6643-6647). When 293 cells expressing the MV receptor SLAM (293/hSLAM) were infected with wtMV(C-) or parental wild-type MV (wtMV), the growth of wtMV(C-) was restricted, particularly during late stages. Enhanced green fluorescent protein-expressing wtMV(C-) consistently induced late-stage cell rounding and cell death in the presence of a fusion-inhibiting peptide, suggesting that the C protein can prevent cell death and is required for long-term MV infection. Neutralizing antibodies against alpha/beta interferon did not restore the growth restriction of wtMV(C-) in 293/hSLAM cells. When cynomolgus monkeys were infected with wtMV(C-) or wtMV, the number of MV-infected cells in the thymus was >1,000-fold smaller for wtMV(C-) than for wtMV. Immunohistochemical analyses showed strong expression of an MV antigen in the spleen, lymph nodes, tonsils, and larynx of a cynomolgus monkey infected with wtMV but dramatically reduced expression in the same tissues in a cynomolgus monkey infected with wtMV(C-). These data indicate that the MV C protein is necessary for efficient MV replication both in vitro and in cynomolgus monkeys.
Female Sex Pheromone as Attractant for Male Codling Moths12 (1966)

Journal Article Female Sex Pheromone as Attractant for Male Codling Moths Get access B. A. Butt, B. A. Butt Entomology Research Division, Agr. Res. Serv., USDA, Yakima, Washington Search for other works by this author on: Oxford Academic PubMed Google Scholar D. O. Hathaway D. O. Hathaway Entomology Research Division, Agr. Res. Serv., USDA, Yakima, Washington Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 59, Issue 2, 1 April 1966, Pages 476–477, https://doi.org/10.1093/jee/59.2.476 Published: 01 April 1966 Article history Accepted: 11 January 1966 Published: 01 April 1966
Telemedicine — The Way Ahead for Medicine in the Developing World (2003)

An e-mail link with the facility to send high-resolution digital images is a cheap and uncomplicated telemedicine method. The Swinfen Charitable Trust helped establish such a link in Patan Hospital Kathmandu, Nepal in March 2000. Over 12 months using this link 42 telemedicine referrals were sent to specialists throughout the world. Referrals were: 36% respiratory medicine; 21% neurology, 21% dermatology; 14% cardiology; 5% nephrology; and 3% radiology--28 had digital pictures attached, of which 96% were of high enough quality on which specialists were able to comment. Thirty-nine replies were received. The average time for a specialist reply was 2 days, and 45% were answered within 24 hours. All replies were judged by independent assessors to be helpful or very helpful for diagnosis, management and education. The assessors decided that in 50% of cases the advice if acted upon would have shortened hospital stay. This pilot study has shown that a low-cost telemedicine link is technically feasible and can be of significant benefit for diagnosis, management and education in a developing world setting.
A FIFO-based architecture for high speed image compression (2002)

Proposes a novel architecture for high-performance wavelet-based image compression. Primarily, performance analysis shows that using the normal implementation technology the proposed architecture can process a real-time video stream of up to 35 frames (512/spl times/512 pixels) per second.
A Short, Flexible Route toward 2‘-<i>C</i>-Branched Ribonucleosides (1997)

A five-step synthesis of 2‘-C-branched ribonucleosides from commercially obtained 1,3,5-tri-O-benzoyl-α-d-ribofuranose (4) is described. The free hydroxyl group of 4 was oxidized in high yield with Dess−Martin periodane reagent. The resultant 2-ketosugar was treated with MeMgBr/TiCl4, CH2CHMgBr/CeCl3, or TMSC⋮CLi/CeCl3, and in each case addition to the ketone proceeded stereoselectively to provide 2-alkylated ribofuranosides. After conversion to the corresponding tetrabenzoyl derivatives, the 2-alkylribofuranosides were coupled to nucleobases under Vorbrüggen persilylation conditions, giving the β-nucleosides with high stereoselectivity. Deprotection with methanolic ammonia provided the title compounds in 17−49% overall yields from 4.
Study on siloxane‐modified polyurethane dispersions from various polydimethylsiloxanes (2005)

Abstract In this work, various polydimethylsiloxanes (PDMS) are incorporated with isophorone diisocyanate (IPDI), 2,2‐bis(hydroxymethyl)propionic acid (DMPA), and poly(tetramethylene oxide) (PTMO) by the prepolymer process to synthesize a series of siloxane‐modified polyurethane dispersions (PUDs) with 35 wt % solid content, viscosities of 20–100 cps, and particle sizes of 40–130 nm. Hydrophobic PDMS was introduced into the PU chain either based on random distribution or through the block segment arrangement. We also establish the composition‐property relationship of PDMS‐PUD, which includes PDMS's type and molecular weight and PDMS‐PUD film's contact angle and mechanical property. The tensile strength of PDMS‐PUD film is decreased with increasing amount of PDMS. Scanning electron microscopy for chemical element analysis indicated that PDMS migrated to the surface much more easily in the block arrangement than in the random distribution. Also, some PDMS‐PUD films show a peau‐like surface, so their PUDs are considered promising to be used in processes for textiles. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 3482–3490, 2005
Effect of oral immunization with recombinant urease on murine Helicobacter felis gastritis (1995)

The ability of oral immunization to interfere with the establishment of infection with Helicobacter felis was examined. Groups of Swiss Webster mice were immunized orally with 250 micrograms of Helicobacter pylori recombinant urease (rUrease) and 10 micrograms of cholera toxin (CT) adjuvant, 1 mg of H. felis sonicate antigens and CT, or phosphate-buffered saline (PBS) and CT. Oral immunization with rUrease resulted in markedly elevated serum immunoglobulin G (IgG), serum IgA, and intestinal IgA antibody responses. Challenge with live H. felis further stimulated the urease-specific intestinal IgA and serum IgG and IgA antibody levels in mice previously immunized with rUrease but activated primarily the serum IgG compartment of PBS-treated and H. felis-immunized mice. Intestinal IgA and serum IgG and IgA anti-urease antibody responses were highest in rUrease-immunized mice at the termination of the experiment. Mice immunized with rUrease were significantly protected (P < or = 0.0476) against infection when challenged with H. felis 2 or 6 weeks post-oral immunization in comparison with PBS-treated mice. Whereas H. felis-infected mice displayed multifocal gastric mucosal lymphoid follicles consisting of CD45R+ B cells surrounded by clusters of Thy1.2+ T cells, gastric tissue from rUrease-immunized mice contained few CD45R+ B cells and infrequent mucosal follicles. These observations show that oral immunization with rUrease confers protection against H. felis infection and suggest that gastric tissue may function as an effector organ of the mucosal immune system which reflects the extent of local antigenic stimulation.
<i>Helicobacter pylori</i> Arginase Inhibits T Cell Proliferation and Reduces the Expression of the TCR ζ-Chain (CD3ζ) (2004)

Helicobacter pylori infects approximately half the human population. The outcomes of the infection range from gastritis to gastric cancer and appear to be associated with the immunity to H. pylori. Patients developing nonatrophic gastritis present a Th1 response without developing protective immunity, suggesting that this bacterium may have mechanisms to evade the immune response of the host. Several H. pylori proteins can impair macrophage and T cell function in vitro through mechanisms that are poorly understood. We tested the effect of H. pylori extracts and live H. pylori on Jurkat cells and freshly isolated human normal T lymphocytes to identify possible mechanisms by which the bacteria might impair T cell function. Jurkat cells or activated T lymphocytes cultured with an H. pylori sonicate had a reduced proliferation that was not caused by T cell apoptosis or impairment in the early T cell signaling events. Instead, both the H. pylori sonicate and live H. pylori induced a decreased expression of the CD3zeta-chain of the TCR. Coculture of live H. pylori with T cells demonstrated that the wild-type strain, but not the arginase mutant rocF(-), depleted L-arginine and caused a decrease in CD3zeta expression. Furthermore, arginase inhibitors reversed these events. These results suggest that H. pylori arginase is not only important for urea production, but may also impair T cell function during infection.
Anchors and Paths in a Hypertext Publishing System (1993)

s are available from the same host in the directory /pub/TR/UBLCS/ABSTRACTS in plain text format. All local authors can be reached via e-mail at the address last-name@cs.unibo.it. UBLCS Technical Report Series 92-1 Mapping Parallel Computations onto Distributed Systems in Paralex, by Ö. Babaogglu, L. Alvisi, A. Amoroso and R. Davoli, January 1992. 92-2 Parallel Scientific Computing in Distributed Systems: The Paralex Approach, by L. Alvisi, A. Amoroso, Ö. Babaoglu, A. Baronio, R. Davoli and L. A. Giachini, February 1992. 92-3 Run-time Support for Dynamic Load Balancing and Debugging in Paralex, by Ö. Babaoglu, L. Alvisi, S. Amoroso, R. Davoli, L. A. Giachini, September 1992. 92-4 Paralex: An Environment for Parallel Programming in Distributed Systems, by Ö. Babaoglu, L. Alvisi, S. Amoroso, R. Davoli, L. A. Giachini, October 1992. 93-1 Consistent Global States of Distributed Systems: Fundamental Concepts and Mechanism, by Ö. Babaoglu and K. Marzullo, January 1993. 93-2 Understanding Non...