gebhart/patrepeval huggingface dataset:
Cross‐linking of mRNA to Proteins by Irradiation of Intact Cells with Ultraviolet Light (1980)

Ehrlich ascites tumor cells were irradiated with ultraviolet light to cross-link intracellular RNAs to their tightly bound proteins. The efficiency of such cross-linking in vivo was measured by two independent methods, namely by phenol/chloroform extraction and by isopycnic centrifugation. After short irradiation times more than 70% of the ribosomal RNAs and more than 80% of the mRNA were found to be cross-linked to protein. The size of the cross-linked RNAs was essentially unchanged, indicating that the irradiation does not lead to extensive fragmentation of the RNA. Covalent poly(A)-containing mRNA-protein complexes were isolated by oligo(dT)-cellulose chromatography in the presence of sodium dodecylsulphate. The complexed proteins were freed from RNA by extensive nuclease degradation and analysed by polyacrylamide gel electrophoresis. The results show that some specific proteins are associated with poly(A)-containing RNA in vivo.
Guidelines for the Management of Tinea Capitis in Children (2010)

Abstract: Practice guidelines for the treatment of tinea capitis (TC) from the European Society for Pediatric Dermatology are presented. Tinea capitis always requires systemic treatment because topical antifungal agents do not penetrate the hair follicle. Topical treatment is only used as adjuvant therapy to systemic antifungals. The newer oral antifungal agents including terbinafine, itraconazole, and fluconazole appear to have efficacy rates and potential adverse effects similar to those of griseofulvin in children with TC caused by Trichophyton species, while requiring a much shorter duration of treatment. They may be, however, more expensive (Grading of recommendation A; strength of evidence 1a). Griseofulvin is still the treatment of choice for cases caused by Microsporum species. Its efficacy is superior to that of terbinafine (Grading of recommendation A; strength of evidence 1b), and although its efficacy and treatment duration is matched by fluconazole (Grading of recommendation A; strength of evidence 1b) and itraconazole (Grading of recommendation A; strength of evidence 1b), griseofulvin is cheaper. It must be noted, however, that griseofulvin is nowadays not available in certain European countries (e.g., Belgium, Greece, Portugal, and Turkey).
Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells (2006)

Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates vascular function is unknown. Here, we identify a previously uncharacterized Nogo-B receptor specific for the amino terminus of Nogo-B and show that Nogo-B receptor localizes with the ligand Nogo-B during VEGF and wound healing angiogenesis in vivo, mediates chemotaxis in a heterologous expression system and chemotaxis, and 3D tube formation in native endothelial cells. Thus, identification of this receptor may lead to the discovery of agonists or antagonists of this pathway to regulate vascular remodeling and angiogenesis.
Extending the database relational model to capture more meaning (1979)

During the last three or four years several investigators have been exploring “semantic models” for formatted databases. The intent is to capture (in a more or less formal way) more of the meaning of the data so that database design can become more systematic and the database system itself can behave more intelligently. Two major thrusts are clear. In this paper we propose extensions to the relational model to support certain atomic and molecular semantics. These extensions represent a synthesis of many ideas from the published work in semantic modeling plus the introduction of new rules for insertion, update, and deletion, as well as new algebraic operators.
Kalman filter estimation of underwater vehicle position and attitude using Doppler velocity aided inertial motion unit (1994)

This Paper explores the use of an extended Kalman filter to provide real-time estimates of underwater vehicle position and attitude. The types of previously available sensors are detailed including strapdown accelerometers, roll and pitch sensors, gyro and magnetic compasses, depth sensor, and various types of acoustic positioning systems. A doppler velocimeter is added to this sensor suite to improve the performance of the filter. As an integral part of the filter, magnetic compass and gyrocompass biases are estimated to improve vehicle heading accuracy. The filter is designed to account for numerous reallife complications. These include varying rates of sensor output, lengthy gaps in reception of position information, presence of non-Gaussian position fix errors (flyers), and varying probability density functions for sensor errors. Simulated data are used to test the filter with varying availability of data and accuracy of initial conditions, along with actual data from a deployment of the towed DSL-120 vehicle. The increased accuracy obtained by using the doppler velocimeter is emphasized.
Haematological and haemorheological changes associated with cigarette smoking. (1985)

A prospective study was undertaken to establish the haematological and haemorheological changes associated with long standing cigarette smoking in 20 heavy smokers and to assess whether any such changes were reversible after smoking was stopped. Highly significant differences were observed in whole blood viscosity, plasma viscosity, plasma fibrinogen concentrations, packed cell volume, and carboxyhaemoglobin concentrations between smokers and non-smokers. Ten of the subjects were followed up for two weeks after stopping smoking by which time whole blood viscosity and carboxyhaemoglobin concentrations had improved significantly and indications of improvement could be seen in all other measurements. Two of these subjects were further followed up for two months when all the measured variables were comparable with those in non-smokers. No correlation could be established between carboxyhaemoglobin concentration and any of the other variables. Although patients' compliance may be difficult to obtain, further prospective studies would be required to confirm our findings.
A Simple Method for the Preparation of Human Serum Albumin<sup>1</sup> (1979)

A simple method, based on ethanol fractionation, for the preparation of highly purified human serum albumin with a higher yield than that of the conventional ethanol procedures is described. It consists of two purification steps, namely, precipitation of most of the other plasma proteins from a 3-fold diluted plasma with ethanol at 42% concentration, pH 5.75 and -5 degrees C, leaving over 96% pure albumin in the supernatant, followed by isoelectric precipitation of albumin from the supernatant at pH 4.8 and -5 degrees C. The paste thus obtained was processed to the final albumin solution according to the conventional methods. The yield of the final albumin with a purity of over 99% was equivalent to 29.5 g/l of plasma representing a recovery of over 93%. The possibility of recovering other plasma proteins and the suitability for large scale preparation are also discussed.
Simulation of wrist kinematics on the basis of a rigid body spring model (2007)

Thesis (Master, Mechanical and Materials Engineering) -- Queen's University, 2007-08-30 16:30:32.543
Regulation of the lic Operon ofBacillus subtilis and Characterization of Potential Phosphorylation Sites of the LicR Regulator Protein by Site-Directed Mutagenesis (1999)

The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a sigma(A)-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. Induction of the operon requires a DNA sequence with dyad symmetry located immediately upstream of the licBCAH promoter. Expression of the lic operon is positively controlled by the LicR regulator protein, which contains two potential helix-turn-helix motifs, two phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) regulation domains (PRDs), and a domain similar to PTS enzyme IIA (EIIA). The activity of LicR is stimulated by modification (probably phosphorylation) of both PRD-I and PRD-II by the general PTS components and is negatively regulated by modification (probably phosphorylation) of its EIIA domain by the specific EII(Lic) in the absence of oligomeric beta-glucosides. This was shown by the analysis of licR mutants affected in potential phosphorylation sites. Moreover, the lic operon is subject to carbon catabolite repression (CCR). CCR takes place via a CcpA-dependent mechanism and a CcpA-independent mechanism in which the general PTS enzyme HPr is involved.
Jamming detection in providing for radar jamming immunity (2009)

The article considers the objective of providing for radar jamming immunity by optimizing the radar structure, parameters or operating algorithms on the basis of correct recognition of jamming in progress. Procedure of recognition in the determined feature space is examined. Viability of this approach is demonstrated using the example of airborne radar operation against the source of polarization and blinking jamming.
Generating with a grammar based on tree descriptions (2001)

While the generative view of language processing builds bigger units out of smaller ones by means of rewriting steps, the axiomatic view eliminates invalid linguistic structures out of a set of possible structures by means of well formedness principles. We present a generator based on the axiomatic view and argue that when combined with a TAG-like grammar and a flat semantics, this axiomatic view permits avoiding drawbacks known to hold either of top-down or of bottom-up generators.
Thin film capacitors embedded into high density printed circuit boards (2001)

This paper describes an approach for embedding high value, thin film capacitors into high density multilayer printed circuit boards. Pb 0.85 La 0.15 (Zr 0.52 Ti 0.48 ) 0.96 O 3 thin films are prepared by chemical solution deposition on 50 μm Ni-coated Cu foils. Capacitance density and loss tangent values range between 300 and 400 nF/cm 2 and 0.01 and 0.02 from 1 to 1000 kHz respectively. Integration of these foils into a standard HDI process. The capacitance densities represent a 2 to 3 order of magnitude improvement over currently available embedded capacitor technologies for polymeric packages.
Clonidine-Induced Vasoconstriction in Awake Volunteers (2001)

We evaluated the vasomotor effects of clonidine in awake subjects with an intact central cardiovascular regulatory system. To determine the lower limit of the vasoconstrictive effect of clonidine in awake volunteers, we blocked sympathetic innervation to the left arm by anesthetizing the brachial plexus. We then measured arterial blood pressure and vasoconstriction via finger volume plethysmography measuring infrared light transmitted through a fingertip (LTF). LTF values obtained from the left arm were compared with those from the neurally intact right arm during four progressively increasing IV doses of clonidine, targeting plasma clonidine concentrations of 0.3, 0.45, 0.68, and 1.0 ng/mL. Clonidine decreased systolic blood pressure (P < 0.004) from 135 ± 8 mm Hg to 115 ± 8 mm Hg and heart rate (P = 0.0017) from 68 ± 7 mm Hg to 61 ± 10 mm Hg. Clonidine decreased LTF by −12% ± 11% (P < 0.0001) less than preinfusion values at the 0.68 ng/mL target concentration in the right hand. In contrast, in the left hand, clonidine increased LTF significantly more than (P < 0.0001) preinfusion values at all target concentrations, with a maximal increase of 30% ± 7%. We conclude that IV clonidine, at doses that decrease arterial blood pressure, causes arterial vasoconstriction in awake subjects.
Machine Learning for Power Allocation of a D2D Network (2019)

Resource optimization for small-cell wireless networks is more complicated than the traditional applications. The solution needs to be delivered promptly to respond the highly dynamic temporal and spatial variations. It seems that the machine learning strategy is more flexible and adaptive than the conventional optimization methods, since ML has the potential to find the implicit function relationship between arbitrary input data and output results. In this work, we focus on a generic D2D network and to show the effectiveness of ML apply to solve the power optimization problem with different optimization models. The research spans over all stages such as analysis, design, implementation, and validation. It is shown that the ML method has achieved several benchmarks in terms of QoS metrics for different optimization models.
TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death (2004)

Besides its well-recognized role in hemostasis and thrombosis, thromboxane A(2) synthase (TXAS) is proposed to be involved in thrombopoiesis and lymphocyte differentiation. To evaluate its various physiologic roles, we generated TXAS-deleted mice by gene targeting. TXAS(-/-) mice had normal bone marrow megakaryocytes, normal blood platelet counts, and normal CD4 and CD8 lymphocyte counts in thymus and spleen. Platelets from TXAS(-/-) mice failed to aggregate or generate thromboxane B(2) in response to arachidonic acid (AA) but produced increased prostaglandin-E(2) (PGE(2)), PGD(2), and PGF(2 alpha). AA infusion caused a progressive drop of mean arterial pressure (MAP), cardiac arrest, and death in wild-type (WT) mice but did not induce shock in TXAS(-/-) mice or in WT and TXAS(-/-) mice treated with antagonist to the thromboxane-prostanoid (TP) receptor. The TXAS(-/-) mice were able to maintain normal MAP upon AA insult when TP was present but were unable to do so when TP was blocked by an antagonist, suggesting a role of endoperoxide accumulation in influencing MAP. We conclude that TXAS is not essential for thrombopoiesis and lymphocyte differentiation. Its deficiency causes a mild hemostatic defect and protects mice against arachidonate-induced shock and death. The TXAS-deleted mice will be valuable for investigating the roles of arachidonate metabolic shunt in various pathophysiologic processes.
An identity-based signature scheme from the Weil pairing (2003)

We come up with an ID-based signature scheme from the Weil pairing. Our scheme is secure if the Diffie-Hellman problem is hard. Furthermore, our signature size is only about a quarter of ID-based Guillou-Quisquater (1988) signature size.
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mfrac><mml:mrow><mml:mi>K</mml:mi><mml:mi>β</mml:mi></mml:mrow><mml:mrow><mml:mi>K</mml:mi><mml:mi>α</mml:mi></mml:mrow></mml:mfrac></mml:math>Radiative-Transition-Probability Ratios for Elements of Low Atomic Numbers in Amorphous and Crystal Forms (1972)

The $\frac{K\ensuremath{\beta}}{K\ensuremath{\alpha}}$ radiative-transition probabilities have been measured for 26 elements ranging in atomic numbers from $_{11}\mathrm{Na}$ to $_{45}\mathrm{Rh}$. The samples were in an amorphous state except $_{17}\mathrm{Cl}$ and $_{35}\mathrm{Br}$, which were in crystal form. The elements $_{11}\mathrm{Na}$, $_{12}\mathrm{Mg}$, $_{19}\mathrm{K}$, and $_{20}\mathrm{Ca}$ were studied in both amorphous and crystal forms. The $K$ vacancies were produced by radiation from commercial $_{74}\mathrm{W}$ and $_{24}\mathrm{Cr}$ x-ray tubes. The corrected measured ratios are compared with the most recent calculations based on a relativistic Hartree-Fock-Slater (RHFS) potential and relativistic screened Coulomb potential. Although the form of the dependence of this ratio on atomic number predicted on the basis of a RHFS potential seems to be correct, the experimental values are consistently higher than the calculated results. Comparison with other recent experimental results is also made.
Semantics-preserving bag-of-words models for efficient image annotation (2009)

The Bag-of-Words (BoW) model is a promising image representation for annotation. One critical limitation of existing BoW models is the semantic loss during the codebook generation process, in which BoW simply clusters visual words in Euclidian space. However, distance between two visual words in Euclidean space does not necessarily reflect the semantic distance between the two concepts, due to the semantic gap between low-level features and high-level semantics. In this paper, we propose a novel scheme for learning a codebook such that semantically related features will be mapped to the same visual word. In particular, we consider the distance between semantically identical features as a measurement of the semantic gap, and attempt to learn an optimized codebook by minimizing this gap. We refer to such a new codebook method as Semantics-Preserving Codebook (SPC) and the corresponding model as Semantics-Preserving Bag-of-Words model (SPBoW). This novel model generates codebook for each object category and only needs to update the codebook for a specific category when incomes an object, which makes it convenient to scale up with the increasing number of objects. Experiments on image annotation tasks with a public testbed from MIT's Labelme project, which contains 11,281 objects of 495 categories, show that the SPC learning scheme is efficient in handling large number of objects and is able to greatly improve the performance of the existing BoW model.
Experiences with and Observations of Direct-Touch Tabletops (2006)

The design of multitouch multiuser tabletop user interfaces is still in its infancy and is not yet well understood. To date, published experimental results have primarily focused on controlled user studies. In this paper, we present observations of user experience "in the wild" on interactive tables in four different real world contexts - all noncontrolled settings. We reflect upon our collective experience, report our observations, and summarize lessons learned by identifying design considerations relating to several aspects of interactive tables, such as simultaneous touching, ambiguous input, one-fingered touch, finger resolution, alternate touch input, crowding and clutter, text input, orientation, multiuser coordination, occlusion, ergonomic issues, and mental models.
Coating flow of non-Newtonian fluids on a flat rotating disk (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoating flow of non-Newtonian fluids on a flat rotating diskSamson A. Jenekhe and Spencer B. SchuldtCite this: Ind. Eng. Chem. Fundamen. 1984, 23, 4, 432–436Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/i100016a009https://doi.org/10.1021/i100016a009research-articleACS PublicationsRequest reuse permissionsArticle Views908Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Sodium regulation of angiotensinogen mRNA expression in rat kidney cortex and medulla. (1986)

Rat liver angiotensinogen cDNA (pRang 3) and mouse renin cDNA (pDD-1D2) were used to identify angiotensinogen and renin mRNA sequences in rat kidney cortex and medulla in rats on high and low salt diet. Angiotensinogen mRNA sequences were present in renal cortex and medulla in apparently equal proportions, whereas renin mRNA sequences were found primarily in renal cortex. Average relative signal of rat liver to whole kidney angiotensinogen mRNA was 100:3. Densitometric analysis of Northern blots demonstrated that renal cortical angiotensinogen mRNA concentrations increased 3.5-fold (P less than 0.001) and medulla, 1.5-fold (P less than 0.005) on low sodium compared with high sodium diet, whereas renal cortex renin mRNA levels increased 6.8-fold (P less than 0.0005). Dietary sodium did not significantly influence liver angiotensinogen mRNA levels. These findings provide evidence for sodium regulation of renal renin and angiotensinogen mRNA expressions, which supports potential existence of an intrarenally regulated RAS and suggest that different factors regulate renal and hepatic angiotensinogen.
Synthesis of Dyed Monodisperse Poly(methyl methacrylate) Colloids for the Preparation of Submicron Periodic Light-Absorbing Arrays (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Dyed Monodisperse Poly(methyl methacrylate) Colloids for the Preparation of Submicron Periodic Light-Absorbing ArraysAlbert S. Tse, Zhijun Wu, and Sanford A. AsherCite this: Macromolecules 1995, 28, 19, 6533–6538Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ma00123a021https://doi.org/10.1021/ma00123a021research-articleACS PublicationsRequest reuse permissionsArticle Views377Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Real Time Measurement of Induced Variation of Birefringence in Transparent Media (1972)

An apparatus permitting high accuracy measurements of fast variation of birefringence in various media has been built using the following principle. A feedback loop cancels automatically the corresponding rotation of the light polarization vector by a calibrated voltage change applied to a KDP crystal. It has been used to measure the optical damage effect in electro-optic crystals such as LiNbO3.