gebhart/patrepeval huggingface dataset:
Transforming growth factor-beta in synovial fluids modulates Fc gamma RII (CD16) expression on mononuclear phagocytes (1992)

Mononuclear phagocytes in the synovium of patients with arthritis, in contrast to blood monocytes, were found to express a third receptor for the constant region of Ig (Fc gamma RIII), in addition to Fc gamma RI and Fc gamma RII. Previously identified on mature mononuclear phagocytes or phagocytes exposed to transforming growth factor-beta (TGF-beta) in vitro, this study documents the presence of Fc gamma RIII (CD16) expressing cells at an inflammatory site. Furthermore, the presence of CD16 on the majority of the LeuM3 (CD14) positive synovial monocytic cells could be mimicked by exposing blood monocytes to synovial fluids from patients with rheumatoid arthritis (17 of 19) and synovial fluids from patients with osteoarthritis (4 of 4). In additional studies, the soluble factor in inflammatory synovial fluids responsible for regulating CD16 expression was found to be consistent with the presence of TGF-beta. Inhibition of the activity in synovial fluids with a neutralizing antibody to TGF-beta confirmed a role for this peptide in synovial phagocytic cell CD16 expression. Moreover, signal transduction through CD16 on synovial phagocytes resulted in augmented extracellular release of superoxide anion that may contribute to tissue damage and other inflammatory sequelae. Identification of TGF-beta and its association with upregulation of CD16 at sites of chronic inflammation may provide insight into the destructive lesions associated with inflammatory arthropathies.
ChemInform Abstract: Complexes of Ruthenium(II) with bpmRe(CO)3Cl and HAT(Re(CO)3Cl)2 as Ligands: Syntheses and Redox and Luminescence Properties. (1989)

Abstract The complexes (IIIb), (IIIc) and (IV) are prepared analogously to (IIIa), starting with the appropriate Ru compound.
High-Repetition-Rate Pulsed-Pump Optical Parametric Amplification in Silicon Waveguides (2008)

The net parametric gain evolution inside the silicon waveguides for high speed optical communications is investigated. Pulsed-pump parametric amplification can be a chip-scale solution for high bit rate DWDM systems with pulse width <;1 ps.
Differentiation‐related changes in mitochondrial properties as indicators of stem cell competence (2006)

Several methods may be used to assess stem cell competence, including the expression of cell surface markers and telomerase activity. We hypothesized that mitochondrial characteristics might be an additional and reliable way to verify stem cell competence. In a multipotent, adult monkey stromal stem cell line, previously shown to differentiate into adipocytes, chondrocytes, and osteocytes, we found that several mitochondrial properties change with increasing passage number in culture. Cells from the earliest passage (P11) versus those from a later passage (P17) are characterized by: (a) a much higher percentage of cells (85% vs. 18%) with a perinuclear arrangement of mitochondria; (b) a much lower percentage of cells (1% vs. 57%) with an aggregated mitochondrial arrangement, in which mitochondria appear to coalesce into large clumps; (c) a much lower percentage of cells with lipid droplets (1% vs. 36%), suggesting less differentiation into adipocytes; (d) a 5.6-fold lower ATP content per cell (0.45 vs. 2.51 pmoles ATP/cell; and (e) a 10-fold higher rate of oxygen consumption (37.8 vs. 3.8 nmoles O2/min/10(3) cells), indicating a higher metabolic activity. Collectively, these data indicate that the perinuclear arrangement of mitochondria, accompanied by a low ATP/cell content and a high rate of oxygen consumption, may be valid indicators of stem cell differentiation competence, while departures from this profile indicate that cells are differentiating or perhaps becoming senescent. These results represent the first characterization of mitochondrial properties reported for a primate stem cell line.
RETCAM FLUORESCEIN GONIOANGIOGRAPHY (2013)

Retcam fluorescein gonioangiography is a novel technique for early detection of angle neovascularization in diabetic retinopathy and hence preventing progression to neovascular glaucoma. The objective nature of this test helps in precise decision making compared with gonioscopy for early intervention especially in cases of pre-PDR.
Effects of Non-Uniform Current Distribution on Energy Density of Li-Ion Cells (2013)

To quantify the impact of non-uniform current distribution in a large-format Li-ion cell on its overall energy density, five cell configurations with different positive tab numbers and locations were developed. This was enabled by a specially designed segmented cell with reconfigurable positive tabs on the outside. Current distribution and overall discharge performance were measured and correlated with each other for all five cell configurations. It is shown that tab number and location have significant effects on the performance and current distribution of a Li-ion battery cell. Fewer tabs typically cause lower performance but excessive tabs do not help. The 1-tab-co-located configuration causes both very non-uniform current distribution and very low overall discharge performance, and should be avoided in tab design for cells bigger than ∼2.4Ah. The effects of tab configuration on overall performance can be attributed to and explained by current distribution. Discharge energy of the experimental cell decreases almost linearly with a current density non-uniformity factor. Non-uniform current distribution results in non-uniform utilization of active materials, reducing energy density, and likely also accelerating degradation of the Li-ion cell. Future research on diagnosing and improving current density uniformity in large format Li-ion batteries that enable vehicle- and grid-energy storage is highly warranted.
Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. (1991)

We have demonstrated translocation of HL-60 cell 5-lipoxygenase to a membrane compartment in response to both the calcium ionophore A23187 and the receptor-mediated stimulus, N-formyl-methionyl-leucyl-phenylalanine (fMLP). In addition, we have shown inhibition of A23187- and fMLP-induced 5-lipoxygenase translocation by an indole and a quinoline leukotriene synthesis inhibitor, MK-886 and L-674,573, respectively. Selectivity of inhibition of 5-lipoxygenase translocation in both fMLP- or A23187-challenged cells is shown using the indole L-583,916 and quinoline L-671,480, which neither inhibit leukotriene synthesis nor inhibit 5-lipoxygenase translocation. The present study in HL-60 cells is the first demonstration of the selective inhibition of 5-lipoxygenase translocation by quinoline leukotriene synthesis inhibitors, exemplified by L-674,573. Also described here is the first demonstration of 5-lipoxygenase translocation and inhibition in response to a stimulus other than A23187, namely the receptor-mediated stimulus, fMLP.
3-D Head Model Retrieval Using a Single Face View Query (2007)

In this paper, a novel 3D head model retrieval approach is proposed, in which only a single 2D face view query is required. The proposed approach will be important for multimedia application areas such as virtual world construction and game design, in which 3D virtual characters with a given set of facial features can be rapidly constructed based on 2D view queries, instead of having to generate each model anew. To achieve this objective, we construct an adaptive mapping through which each 2D view feature vector is associated with its corresponding 3D model feature vector. Given this estimated 3D model feature vector, similarity matching can then be performed in the 3D model feature space. To avoid the explicit specification of the complex relationship between the 2D and 3D feature spaces, a neural network approach is adopted in which the required mapping is implicitly specified through a set of training examples. In addition, for efficient feature representation, principal component analysis (PCA) is adopted to achieve dimensionality reduction for facilitating both the mapping construction and the similarity matching process. Since the linear nature of the original PCA formulation may not be adequate to capture the complex characteristics of 3D models, we also consider the adoption of its nonlinear counterpart, i.e., the so-called kernel PCA approach, in this work. Experimental results show that the proposed approach is capable of successfully retrieving the set of 3D models which are similar in appearance to a given 2D face view.
Translucent optical networks: the way forward [Topics in Optical Communications] (2007)

The transmission reach of signals in optical transmission systems is limited. To go beyond these transparent reach limits, signal regeneration is necessary to re-amplify, reshape, and retime the optical signals. Translucent optical networks are a type of optical transport network specifically devised to address such a concern by allowing for sparse but strategic signal regeneration in the network. Translucent optical networks seek a graceful balance between network design cost and service provisioning performance, and can achieve performance comparable to that of an all-electronic switching network, but requiring far fewer signal regenerators. Despite massive progress, there are many outstanding issues regarding the implementation of translucent networks planning and operation. This article reviews a range of translucent optical networks and discusses various research issues, particularly involving network planning, lightpath routing and wavelength assignment, and network survivability. We also suggest other potential research topics such as traffic grooming, fault detection, and multicasting for translucent networks
A Novel Method for the Extrinsic Calibration of a 2D Laser Rangefinder and a Camera (2018)

We present a novel method for extrinsically calibrating a camera and a 2D laser rangefinder whose beams are invisible from the camera image. We show that the point-to-plane constraints from a single observation of a V-shaped calibration pattern composed of two non-coplanar triangles suffice to uniquely constrain the relative pose between two sensors. Next, we present an approach to obtain analytical solutions using point-to-plane constraints from single or multiple observations. Along the way, we also show that the previous solutions, in contrast to our method, have inherent ambiguities and therefore must rely on a good initial estimate. Real and synthetic experiments validate our method and show that it achieves better accuracy than the previous methods.
Characterization of a Hypoallergenic Recombinant Bet v 1 Variant as a Candidate for Allergen-Specific Immunotherapy (2007)

Due to its reduced IgE reactivity and decreased capacity to activate basophils, but retained T cell reactivity and strong immunogenicity, rBet v 1-FV proved to be a very promising candidate for specific immunotherapy in birch pollen-allergic subjects.
Immune cell responses to amyloid-beta proteins: What is the extent and implications of amyloid-beta induced cytotoxicity in microglial cells and peripheral blood mononuclear cells? (2017)

Alzheimer’s disease (AD) is a neurodegenerative disease with cognitive and physical symptoms. Scientists generally accept the amyloid cascade hypothesis as the defining focus of AD pathology. Past studies have indicated that Aβ oligomers induced cytotoxicity in immune cells, but the role of Aβ monomers has remained largely unexplored. The purpose of this study is to confirm the cytotoxicity exhibited by Aβ oligomer and immune cell interactions, and to discover whether Aβ monomer interactions will produce a similar response. We used lyophilized Aβ peptides to generate monomers and oligomers, and then added them into cultured BV2 microglial cells and peripheral blood mononuclear cells (PBMCs). After incubation, we used a Glo-Assay procedure to measure Aβ induced cytotoxicity based on cell viability. Ultimately, it was found that Aβ oligomers were more prone to induce cytotoxicity than monomers. The results imply that PBMCs show a greater sensitivity to Aβ proteins than microglial cells.
Modified NOLM for Stable and Improved 2R Operation at Ultra-High Bit Rates (2006)

A nonlinear optical fiber loop mirror (NOLM) adapted for all-optical 2R operation at ultrahigh bit-rates was experimentally and theoretically investigated. The proposed NOLM was created by adding inline/external fiber polarizers and also an inline optical phase-bias compensator (OPBC) to a standard NOLM. A theoretical investigation revealed that the operation of the standard NOLM became unstable due to residual polarization crosstalk of the polarization-maintaining optical components making up the NOLM, and that it could be dramatically improved with the inline/external polarizers. The NOLM with the polarizers ensured stable switching operation with high switching-dynamic-range (> 30dB) against the change of the wavelength of the input clock pulses, and the change of the environment temperature. We also experimentally verified that the OPBC played a dramatic role to ensure excellent dynamic switching performance of the NOLM, and to achieve signal-Q-recovery of the regenerated signals. All optical 2R experiments at 40Gb/s and 160Gb/s were performed with the modified NOLM. Signal regeneration with improved extinction ratio and signal Q value was successfully demonstrated. Q-recovery to the input of the control pulses degraded with ASE noise accumulation was also successfully achieved.
CREATION OF BIOACTIVE SURFACES TO MODULATE CELL BEHAVIOR USING SURFACE INITIATED PHOTOINIFERTER- MEDIATED GRAFT PHOTOPOLYMERIZATION (2009)

Biomaterials widely used in biomedical applications still face biocompatibility issues arising from non-specific protein adsorption on the foreign surface, and the consequent undesired cell response. Emerging evidence suggests that imparting specific bioactivity to the biomaterial's surface to elicit favorable response from cells, (like osseointegration of joint implants and endothelialization of stents) can yield much better biocompatibility results when combined with passive prevention of protein adsorption. In more complex diseases like spinal cord injury and cardiomyopathy, specific biomolecules are required to elicit desired cell responses for successful regeneration. However, for success of such biomolecule based strategies, the effects of various parameters (type of molecule, concentration, spatial and temporal distribution) on the behavior of target cells need to be thoroughly investigated. Surface-initiated photoiniferter-mediated polymerization (SIPMP) was selected for this study, because it: 1. can graft protein-resistant polymer (like poly(ethylene glycol) (PEG), poly(hydroxyethyl methacrylate) (HEMA)) on any biomaterial surface. 2. provides excellent control over the amount of polymer grafted. 3. allows covalent immobilization of biomolecules on the polymer chains, and 4. allows creation of spatial patterns and concentration gradients of biomolecules by spatially controlling polymer grafting. As the first step, poly(methacrylic acid) (pMAA) grafting via SIPMP was used to systematically control the hydrophilicity and the concentration of attached molecules on polyurethane surfaces by varying the iniferter concentration, monomer concentration, UV intensity and UV exposure time. In the next step, covalent conjugation of a hormone noradrenalin (NA) to pMAA and pHEMA chains grafted on glass surfaces was achieved as a means to develop a novel anti-marine biofouling surface. Accessibility and bioactivity of conjugated NA was confirmed by its deleterious effects on viability and cell structure of oyster hemocytes. Finally, thickness gradients of pMAA and pHEMA chains were created on glass surface as a means to create protein concentration gradients and study their effects on gradient-dependent cell behaviors. Preliminary experiments for controlling cell adhesion by conjugating proteins to homogeneous pHEMA layers remain inconclusive, warranting further investigation. In summary, the results obtained in this study highlight the versatility of SIPMP for high throughput analysis of cell behavior on surfaces with a wide variety of bioactive functionalities.
Double-stranded RNA Signaling by Toll-like Receptor 3 Requires Specific Tyrosine Residues in Its Cytoplasmic Domain (2003)

Double-stranded (ds) RNA, a common product of viral infection, can induce transcription of many cellular genes, including the 561 gene that encodes P56, a regulator of protein synthesis. Here, we report that induction of the 561 mRNA by exogenous dsRNA is mediated by Toll-like receptor 3 (TLR3), and it requires no new protein synthesis. Because gene induction by dsRNA is blocked by inhibitors of tyrosine kinases, we investigated the potential roles of the five tyrosine residues present in the cytoplasmic domain of TLR3 by their individual and combinatorial mutations. Transfection assays, using a reporter gene driven by the 561 promoter, identified specific tyrosine residues to be essential for TLR3 signaling. This conclusion was further validated in permanent cell lines expressing tyrosine-mutant TLR3 proteins; in some of these cell lines dsRNA failed to induce the 561 mRNA. Our results provide the first demonstration of the importance of TLR3 cytoplasmic tyrosine residues in dsRNA signaling.
Socially assisted multi-view video viewer (2011)

We have developed a novel viewer for multi-point video with a socially accumulated viewing log for viewing assistance. The viewer uses annotations of objects in the scene and stabilizes the viewpoint to the user-selected object(s) along with the viewing-point selections.Starting from discussion on two viewing interfaces, i.e. camera-centered and target-centered, we propose a novel socially assisted viewing interface as a director-agent assisted target-centered system. A histogram of the viewing log in terms of time, camera and target of many people's viewing experiences, which we call a viewgram, is used as the source of the director agent, which exploits the viewgram as the visualized popular viewing behavior for particular content. The system can compose the most preferred viewing sequence by referring to the viewgram, for example. The viewgram can also be used as a map of preferences useful in choosing the viewing point.
Structural Investigation of Monoclinic‐Rhombohedral Phase Transition in Na <sub>3</sub> Zr <sub>2</sub> Si <sub>2</sub> PO <sub>12</sub> and Doped <scp>NASICON</scp> (2015)

Aliovalent doping of the zirconium site in Na 3 Zr 2 Si 2 PO 12 ( NASICON ) was performed with a range of +3 (Al, Y, Fe) and +2 (Co, Ni, Zn) valent cations. The monoclinic‐rhombohedral phase transition was analyzed with high‐temperature in situ X‐ray diffraction, and differential scanning calorimetry ( DSC ). From the lattice parameters extracted at room temperature up to 300°C it was determined that the high‐temperature rhombohedral phase distorts to the low‐temperature monoclinic phase through a shear deformation of the unit cell. DSC confirmed the phase transition and demonstrated that the phase transition temperature was lowered by doping the NASICON structure. Furthermore, the distortion of the lattice was less severe for all doped samples. Ultimately aliovalent substitution for zirconium stabilized the higher symmetry rhombohedral phase of NASICON , with yttrium doping providing the lowest phase transition temperature and the smallest distortion of the lattice through the phase change.
Ranking open source application integration frameworks based on maintainability metrics: A review of five‐year evolution (2019)

Summary Integration frameworks are specialized software tools built and adapted to facilitate the design and implementation of integration solutions. An integration solution allows for the reuse of applications from the software ecosystem of companies to support their business processes. There are several open‐source integration frameworks available on the market designed to operate in a business context to manipulate structured data; however, increasingly, they are required to deal with unstructured and large volumes of data, thus requiring effort to adapt these frameworks to work with unstructured and large volume of data. Choosing the framework, which is the easiest to be adapted, is not a trivial task. In this article, we review the newest stable versions of four open‐source integration frameworks by analyzing how they have evolved regarding their adaptive maintainability over five years. We rank them according to their maintainability degree and compare past and current versions of each framework. To encourage and enable researchers and developers to replicate our experiments, with the aim of verifying our findings, and to experiment with new versions of the integration frameworks analyzed, we detail the experimental protocol used while also having made all the required software involved available on the Web.
The ESPRIT project CAFE - High security digital payment systems (1994)

. CAFE (&quot;Conditional Access for Europe&quot;) is an ongoing project in the European Community&apos;s ESPRIT program. The goal of CAFE is to develop innovative systems for conditional access, and in particular, digital payment systems. An important aspect of CAFE is high security of all parties concerned, with the least possible requirements that they are forced to trust other parties (so-called multi-party security). This should give legal certainty to everybody at all times. Moreover, both the electronic money issuer and the individual users are less dependent on the tamper-resistance of devices than in usual digital payment systems. Since CAFE aims at the market of small everyday payments that is currently dominated by cash, payments are offline, and privacy is an important issue. The basic devices used in CAFE are so-called electronic wallets, whose outlook is quite similar to pocket calculators or PDAs (Personal Digital Assistant). Particular advantages of the electronic wallets are that PIN...
An approach to text classification using dimensionality reduction and combination of classifiers (2005)

Text classification involves assignment of predetermined categories to textual resources. Applications of text classification include recommendation systems, personalization, help desk automation, content filtering and routing, selective alerting, and text mining. This paper describes an experiment for improving the classification accuracy of a large text corpus by the use of dimensionality reduction and multiple-classifier combination techniques. Three different classifiers have been used namely Naive Bayes, J48 decision tree and decision table. The results of these classifiers are combined using techniques such as simple voting, weighted voting and probability-based voting. The classification accuracy is further improved by the use of a dimensionality reduction method based on concept indexing. Experiments conducted on the Reuters 21578 dataset indicate that the combination approach provides an improved and scalable method for text classification. Also, it is observed that concept indexing helps with classification accuracy in addition to efficiency and scalability.