gebhart/patrepeval huggingface dataset:
Sensitivity study of channel termination on vertical side-chip interconnection (2012)

This paper investigates the sensitivity of channel termination on vertical side-chip interconnection (VSCI), an alternative high density and low z-height enabler for 3D packaging technology. In this study, the trends of eye height opening, one of the critical signaling parameters, were analyzed based on transmission channel length, input rise time, receiver device capacitance and termination resistance factors. Simulation results show potential solution space for weak receiver termination to achieve >350mV eye height opening (based on 1V supply voltage) at 30Gbps. Key enabling factors and design trade-offs were discussed and summarized in this paper for future design considerations.
New Core Analysis Techniques for Naturally Fractured Reservoirs (1985)

Abstract This paper reviews existing core analysis technology and discusses its limitations when used for the evaluation of naturally fractured reservoirs like the Monterey Formation. New core analysis techniques and equipment are presented which can improve the quality of core analysis data and the results of a core study using these methods are reported.
Functionalization of Magnetic Nanoparticles with Amphiphilic Block Copolymers: Self-Assembled Thermoresponsive Submicrometer Particles (2012)

For the first time the four block copolymers derived from 1-alkyl[2-(acryloyloxy)ethyl]dimethylammonium bromides with hexyl (ADA) or cetyl (ADHA) groups and 2-hydroxyethylacrylate (HEA) or N-isopropylacrylamide (NIPAM) were synthesized and employed for functionalization of monodisperse iron oxide nanoparticles (NPs). The polyADA (pADA) or polyADHA (pADHA) block consists of long hydrophobic tails (C(6) or C(16)) connected to a positively charged quaternary ammonium group, making this block amphiphilic. The second block was either fully hydrophilic (pHEA) or thermoresponsive (pNIPAM). The dependence of the NP coating on the length of the hydrophobic tail in the amphiphilic block, the composition of the hydrophilic block, and the NP sizes have been studied. Unusual self-assembling of iron oxide NPs into well-defined composite submicrometer particles was observed for pADHA-b-pNIPAM in the wide range of concentrations (at the pADHA repeating unit concentrations of 0.065 × 10(-2)-2.91 × 10(-2) mmol/mL per 1 mg/mL NPs) but only two concentrations, 1.62 × 10(-2) and 1.94 × 10(-2) mmol/mL, led to regular spherical particles. The thermoresponsive behavior of these composite particles was tested using ζ-potential and dynamic light scattering measurements, while the morphology of particles was characterized by transmission electron microscopy. Coating of NPs with pADHA-b-pHEA results in the formation of individually coated NPs. The different composite particle morphologies are explained by different properties of pHEA and pNIPAM. It is demonstrated that the composite particles based on pADHA-b-pNIPAM are responsive to a magnetic field and can be recommended as magnetic stoppers in biorelated membrane separations. The incorporation of Pd species in submicrometer particles makes them promising candidates for catalytic applications as magnetically recoverable catalysts with a high magnetic response.
Rational Combination Therapy in Refractory Migraine (2008)

Refractory migraine (RM) headaches pose important treatment challenges to the patients who live with them and the clinicians who try to treat them. Defined based on the lack of response to acute, preventive, and nonpharmacologic treatment, RM is often treated with a combination of treatments. Although combination therapy for RM has not been systematically studied in randomized trials, clinical experience suggests that a rational approach to RM treatment, utilizing a combination of treatments, may be effective where monotherapy has failed. In this article we briefly identify patient populations appropriate for more aggressive migraine prevention with combination therapy. We then discuss modifiable risk factors and comorbidities in migraine and then focus on the use of rational combination therapy, as well as the duration migraine preventatives should be considered for use. Future research is needed to evaluate the full potential of rational combination treatment as a strategy for treating and ultimately preventing RM.
The SumoDacs-project: Secure mobile data access with a tamperproof hardware token (2010)

Most experts would support the statement that mobile computers with the capability of wireless data communication (e.g., smartphones, netbooks) provide a great potential for the improvement of business processes. Using these technologies mobile employees can access enterprise information systems when they are working outside their company's premises. However, the employment of mobile technologies comes along with specific security issues: mobile computers often get lost or stolen and wireless data communication is much more vulnerable than conventional communication. To tackle these security issues the project SumoDacs was initiated. SumoDacs is based on the employment of a so called Hardware Security Token, which is a special smart card that is resistant even against direct physicals attacks. The enterprise systems to be accessed reside in a secured network segment and are connected with special wrappers to a dedicated security server. A further special feature is a dynamic access control which considers contextual information for making access control decisions.
An Investigation of Cane-Molasses Distillery Slop with Special Reference to Certain Organic Acids (1929)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Investigation of Cane-Molasses Distillery Slop with Special Reference to Certain Organic AcidsE. K. Nelson and C. A. GreenleafCite this: Ind. Eng. Chem. 1929, 21, 9, 857–859Publication Date (Print):September 1, 1929Publication History Published online1 May 2002Published inissue 1 September 1929https://pubs.acs.org/doi/10.1021/ie50237a015https://doi.org/10.1021/ie50237a015research-articleACS PublicationsRequest reuse permissionsArticle Views21Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
MgO based picotesla field sensors (2008)

MgO magnetic tunnel junctions with RA=150Ωμm2 and tunnel magnetic resistance=100% were patterned into pillars with different geometries with areas up to 2000μm2. Sensors were incorporated in 500nm thick Co94Zr3Nb4 flux guides with different shapes and free layer stabilization was achieved through internal (Co66Cr16Pt18 pads) and external longitudinal bias fields (3.5mT). Sensitivities of 870%∕mT were obtained in the center of the transfer curve. Noise levels of 97pT∕Hz0.5 at 10Hz, 51pT∕Hz0.5 at 30Hz, and 2pT∕Hz0.5 at 500kHz were measured in the linear region of the transfer curve.
Low dose imipramine improves chest pain but not quality of life in patients with angina and normal coronary angiograms (1998)

Imipramine reduces the incidence of chest pain in patients with chest pain and normal coronaries who remain symptomatic despite conventional anti-anginal therapy. The failure to demonstrate associated improvements in quality of life may have been due to the high incidence of side effects.
Seismic waveform inversion in the frequency domain; Part 2; Fault delineation in sediments using crosshole data (1999)

Abstract A crosshole experiment was carried out in a layered sedimentary environment in which a normal fault is known to cut through the section. Initial traveltime inversions produced stable but low-resolution images from which the fault could be only vaguely inferred. To image the fault, wavefield inversion was used to produce a velocity model consistent with the detailed phase and amplitude of the data at a number of frequencies. Our wavefield inversion scheme uses a classical, descent-type algorithm for decreasing the data misfit by iteratively computing the gradient of this misfit by repeated forward and backward propagations. Our propagator is a full-wave equation, frequency-domain, acoustic, finite-difference method. The use of the frequency-space domain yields computational advantages for multisource data and allows an easy incorporation of viscous effects. By running wavefield inversion on the field data, a quantitative velocity image was produced that yielded a significantly improved image of the fault (when compared with the original traveltime inversions). Because the original field data were noisy and contained a high degree of multiple scattering (from the layering of the sediments), the transmitted arrivals were selectively windowed to enhance the image. The sediments at the site were strongly attenuating; we therefore used a viscoacoustic model during the modeling and the inversion that correctly simulated the observed decrease in amplitude with increasing frequency and source-receiver offset. Furthermore, since the traveltime inversion indicated a high degree of anisotropy at the site, a fixed, homogeneous level of anisotropy was used during the inversion. Tests at varying levels of anisotropy confirmed the improvement in image quality and in data fit when anisotropy was incorporated. The final image was verified by examining the distribution of the residuals in the frequency domain, by comparing time-domain modeled wavefields with the observed data, and by direct comparison with borehole logs.
A Longitudinal Follow-Up Study of Saffron Supplementation in Early Age-Related Macular Degeneration: Sustained Benefits to Central Retinal Function (2012)

Objectives. In a previous randomized clinical trial (Falsini et al. (2010)), it was shown that short-term Saffron supplementation improves retinal flicker sensitivity in early age-related macular degeneration (AMD). The aim of this study was to evaluate whether the observed functional benefits from Saffron supplementation may extend over a longer follow-up duration. Design. Longitudinal, interventional open-label study. Setting. Outpatient ophthalmology setting. Participants. Twenty-nine early AMD patients (age range: 55-85 years) with a baseline visual acuity >0.3. Intervention. Saffron oral supplementation (20 mg/day) over an average period of treatment of 14 (±2) months. Measurements. Clinical examination and focal-electroretinogram-(fERG-) derived macular (18°) flicker sensitivity estimate (Falsini et al. (2010)) every three months over a followup of 14 (±2) months. Retinal sensitivity, the reciprocal value of the estimated fERG amplitude threshold, was the main outcome measure. Results. After three months of supplementation, mean fERG sensitivity improved by 0.3 log units compared to baseline values (P < 0.01), and mean visual acuity improved by two Snellen lines compared to baseline values (0.75 to 0.9, P < 0.01). These changes remained stable over the follow-up period. Conclusion. These results indicate that in early AMD Saffron supplementation induces macular function improvements from baseline that are extended over a long-term followup.
ESPRIT-Forest: Parallel clustering of massive amplicon sequence data in subquadratic time (2017)

The rapid development of sequencing technology has led to an explosive accumulation of genomic sequence data. Clustering is often the first step to perform in sequence analysis, and hierarchical clustering is one of the most commonly used approaches for this purpose. However, it is currently computationally expensive to perform hierarchical clustering of extremely large sequence datasets due to its quadratic time and space complexities. In this paper we developed a new algorithm called ESPRIT-Forest for parallel hierarchical clustering of sequences. The algorithm achieves subquadratic time and space complexity and maintains a high clustering accuracy comparable to the standard method. The basic idea is to organize sequences into a pseudo-metric based partitioning tree for sub-linear time searching of nearest neighbors, and then use a new multiple-pair merging criterion to construct clusters in parallel using multiple threads. The new algorithm was tested on the human microbiome project (HMP) dataset, currently one of the largest published microbial 16S rRNA sequence dataset. Our experiment demonstrated that with the power of parallel computing it is now compu- tationally feasible to perform hierarchical clustering analysis of tens of millions of sequences. The software is available at http://www.acsu.buffalo.edu/∼yijunsun/lab/ESPRIT-Forest.html.
Preparation of Plastic and Biopolymer Multilayer Films by Plasma Source Ion Implantation (2002)

The plasma source ion implantation (PSII) technique was used to improve the adhesion between linear low-density polyethylene (LLDPE) and biopolymer. LLDPE was treated with the PSII using O(2) or CF(4) gas to modify its surface. After modification, chitosan or corn zein was used for coating on LLDPE. Wettability of the LLDPE surface was evaluated with a contact angle meter by the sessile drop method. X-ray photoelectron spectroscopy (XPS) was used to analyze the LLDPE surface. Before and after treatment, in the case of LLDPE treated with O(2) PSII, oxygen-containing functional groups were formed on the implanted surface. In the CF(4) PSII treated LLDPE, it was observed that the fluorine concentration on the surface of LLDPE remarkably increased and hydrophobic groups were formed by chemical reaction. Bilayer films coated with chitosan or corn zein showed 10 times lower oxygen permeability. Tensile strength of multilayer films was decreased a little compared with that of LLDPE. The plastic and biopolymer multilayer films have potential for food packaging application because of their O(2) gas barrier property and easy recyclability of the multilayer film.
BalanceFlow: Controller load balancing for OpenFlow networks (2012)

In the discussion about Future Internet, Software-Defined Networking (SDN), enabled by OpenFlow, is currently seen as one of the most promising paradigm. While the availability and scalability concerns rises as a single controller could be alleviated by using replicate or distributed controllers, there lacks a flexible mechanism to allow controller load balancing. This paper proposes BalanceFlow, a controller load balancing architecture for OpenFlow networks. By utilizing CONTROLLER X action extension for OpenFlow switches and cross-controller communication, one of the controllers, called “super controller”, can flexibly tune the flow-requests handled by each controller, without introducing unacceptable propagation latencies. Experiments based on real topology show that BalanceFlow can adjust the load of each controller dynamically.
Laser : a layout sensitivity explorer : report and user's manual (1989)

As the IC pattern resolutions tend 10 become smaller the layout geometry plays a more important role in IC yield. The probability that a chip will fail is directly related to the way that the IC artwork is laid out. By examining the possible places where catastrophic defects may occur one can prevent potential faults, and thus estimate the reliability of the design. Rrealistic yield simulation tools must consider the specific layout. It is, therefore, ideal a CAE tool that automatically explores and predicts the layout reliability for real environmentai conditions prevailing in the manufacturing line. We present a system capable of interactively finding the critical areas for shorts and breaks, the sensitivity, and the yield of the IC artwork,for any range of defect sizes. The implementation is based on a simple scanline algorithm and performs only one layout extraction for any span of defect sizes
Repair of Aberrant Splicing in Growth Hormone Receptor by Antisense Oligonucleotides Targeting the Splice Sites of a Pseudoexon (2010)

The exon-skipping ASO approach was effective in correcting aberrant GHR splicing and may be a promising therapeutic tool.
Absorption from the peritoneal cavity: Sem study of the mesothelium covering the peritoneal surface of the muscular portion of the diaphragm (1977)

Colored tracers, injected intraperitoneally in mice, are taken up by diaphragmatic lymphatics, outlining their large, terminal cisterns, the so-called lacunae. The lacunae occur exclusively on the muscular portion of the diaphragm. The mesothelium covering non-lacunar and lacunar areas of the muscular portion was examined with the SEM. Mesothelial cells overlying non-lacunar areas are extremely flat, and their boundaries are indistinct. Mesothelial cells overlying lacunae protrude towards the lumen of the peritoneal cavity and have distinct outlines. There are openings or stomata, 4-12 micron in diameter, between them. Some of the stomata overlie a deep pit; others overlie a shallower pit in which the surface of another cell can be seen beneath the opening. It seems likely that the bulk of the fluid draining from the peritoneal cavity passes through these stomata into underlying lymphatic lacunae.
Pharmacologic Management of Duchenne Muscular Dystrophy: Target Identification and Preclinical Trials (2014)

Duchenne muscular dystrophy (DMD) is an X-linked human disorder in which absence of the protein dystrophin causes degeneration of skeletal and cardiac muscle. For the sake of treatment development, over and above definitive genetic and cell-based therapies, there is considerable interest in drugs that target downstream disease mechanisms. Drug candidates have typically been chosen based on the nature of pathologic lesions and presumed underlying mechanisms and then tested in animal models. Mammalian dystrophinopathies have been characterized in mice (mdx mouse) and dogs (golden retriever muscular dystrophy [GRMD]). Despite promising results in the mdx mouse, some therapies have not shown efficacy in DMD. Although the GRMD model offers a higher hurdle for translation, dogs have primarily been used to test genetic and cellular therapies where there is greater risk. Failed translation of animal studies to DMD raises questions about the propriety of methods and models used to identify drug targets and test efficacy of pharmacologic intervention. The mdx mouse and GRMD dog are genetically homologous to DMD but not necessarily analogous. Subcellular species differences are undoubtedly magnified at the whole-body level in clinical trials. This problem is compounded by disparate cultures in clinical trials and preclinical studies, pointing to a need for greater rigor and transparency in animal experiments. Molecular assays such as mRNA arrays and genome-wide association studies allow identification of genetic drug targets more closely tied to disease pathogenesis. Genes in which polymorphisms have been directly linked to DMD disease progression, as with osteopontin, are particularly attractive targets.
Isotropic spherical source analysis for ocean optics (2000)

Plane-to-point transformations are used to develop a version of the Hydrolight computer program with which to compute the spatial dependence of the irradiance and the scalar irradiance of the light field away from an isotropic point source deep within a spatially uniform ocean. The transformations are also used to derive analytic approximations for determining the diffuse attenuation coefficient and the mean cosine of the radiance far from an isotropic point source. Approximations for determining the asymptotic diffuse attenuation coefficient from measurements at only two distances far from the source are derived and numerically tested with the modified version of the Hydrolight computer program. New spatial integrals of the outward irradiance are also derived that provide a different way for correlating the inherent optical properties of seawater.
Analysis of secure handover for IEEE 802.1x-based wireless ad hoc networks (2007)

The handover procedure in secure communication wireless networks is an extremely time-consuming phase, and it represents a critical issue in relation to the time constraints required by certain real-time traffic applications. In particular, in the case of the IEEE 802.1X model, most of the time required for a handover is used for packet exchanges that are required for authentication protocols, such as Extensible Authentication Protocol Transport Layer Security (EAP-TLS), that require an eight-way handshake. Designing secure re-authentication protocols to reduce the number of packets required during a handover is an open issue that is gaining interest with the advent of a pervasive model of networking that requires realtime traffic and mobility. This article presents the 802.1X model and evaluates its application to ad hoc networks based on IEEE 802.11 i or IEEE 802.1 be standards, focusing on the problems that must be evaluated when designing handover procedures, and suggesting guidelines for securing handover procedures. It also presents a novel protocol to perform secure handovers that is respectful of the previous analysis and that has been implemented in a mesh environment.
Solid-Phase Synthesis of Tetrahydropyridazinedione-Constrained Peptides (2014)

The design and solid-phase synthesis of tetrahydropyridazine-3,6-dione (Tpd) peptidomimetics derived from backbone-aminated peptides is reported. The described protocol features the synthesis of chiral α-hydrazino acids suitable for chemoselective incorporation into growing peptide chains. Acid-catalyzed cyclization to form the Tpd ring during cleavage affords the target peptidomimetics in good yield and purity. The scope of Tpd incorporation is demonstrated through the synthesis of constrained peptides featuring nucleophilic/electrophilic side chains and sterically encumbered α-substituted hydrazino acid residues.
An efficient Monte Carlo-based algorithm for scatter correction in keV cone-beam CT (2009)

A new method is proposed for scatter-correction of cone-beam CT images. A coarse reconstruction is used in initial iteration steps. Modelling of the x-ray tube spectra and detector response are included in the algorithm. Photon diffusion inside the imaging subject is calculated using the Monte Carlo method. Photon scoring at the detector is calculated using forced detection to a fixed set of node points. The scatter profiles are then obtained by linear interpolation. The algorithm is referred to as the coarse reconstruction and fixed detection (CRFD) technique. Scatter predictions are quantitatively validated against a widely used general-purpose Monte Carlo code: BEAMnrc/EGSnrc (NRCC, Canada). Agreement is excellent. The CRFD algorithm was applied to projection data acquired with a Synergy XVI CBCT unit (Elekta Limited, Crawley, UK), using RANDO and Catphan phantoms (The Phantom Laboratory, Salem NY, USA). The algorithm was shown to be effective in removing scatter-induced artefacts from CBCT images, and took as little as 2 min on a desktop PC. Image uniformity was greatly improved as was CT-number accuracy in reconstructions. This latter improvement was less marked where the expected CT-number of a material was very different to the background material in which it was embedded.