gebhart/patrepeval huggingface dataset:
Results of bacteriophage treatment of suppurative bacterial infections in the years 1981-1986. (1987)

In the years 1981-1986 bacteriophage therapy was applied in 550 cases (100 treated in 1986) of suppurative bacterial infections. Positive results were obtained in 508 cases (92.4%). In 38 cases (6.9%) a transient improvement was observed and in 4 cases (0.7%) phage treatment proved ineffective. Considering that majority of patients (518 cases, 94.2%) were resistant to antibiotic treatment, the results of phage therapy may be regarded as favorable.
Comparative study of some selected reactions of homogeneous and polymer-supported lithium diorganocuprates (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparative study of some selected reactions of homogeneous and polymer-supported lithium diorganocupratesRobert H. Schwartz and Joseph San Filippo Jr.Cite this: J. Org. Chem. 1979, 44, 15, 2705–2712Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/jo01329a023https://doi.org/10.1021/jo01329a023research-articleACS PublicationsRequest reuse permissionsArticle Views999Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A framework for integrated operations management and control (1993)

Lasdon and Baker (1986) introduced a framework for plant wide online hierarchical control as an integration of planning, scheduling and process control. A hierarchy is proposed consisting of six layers; strategic planning, tactical planning, systems operations planning, plant operations planning, scheduling, and process control. In the context of this paper, integrated operations management and control is a subset of plant wide control and is concerned with integrated operations management, control system coordination, and assessment. These three functions are arranged within a functional multilayer hierarchy which is considered to be operating on top of a distributed computer control system (DCS) regulating an industrial process plant complex. Here, the integrated operations management unit perform the system and plant operations planning functions of the Lasdon and Baker hierarchy, and the control system coordination unit performs the lower two functions of short term scheduling and process control. The strategic and tactical planning functions are, for the time being, considered to be outside the current considered framework but provide production goals as input. However, an additional function of assessment is introduced within the framework. The system is analysed.
Effects of eccentric treadmill running on mouse soleus: degeneration/regeneration studied with Myf‐5 and MyoD probes (2003)

These results show that this protocol of eccentric exercise is able to induce a drastic degeneration/regeneration process in the soleus muscle. This offers the opportunity to perform biochemical and molecular analyses of a process of regeneration without muscle environment defects. The advantages of this model are discussed in the context of fundamental and therapeutical perspectives.
Audio-to-text alignment for speech recognition with very limited resources (2014)

In this paper we present our efforts in building a speech recognizer constrained by the availability of very limited resources. We consider that neither proper training databases nor initial acoustic models are available for the target language. Moreover, for the experiments shown here, we use grapheme-based speech recognizers. Most prior work in the area use initial acoustic models, trained on the target or a similar language, to force-align new data and then retrain the models with it. In the proposed approach a speech recognizer is trained from scratch by using audio recordings aligned with (sometimes approximate) text transcripts. All training data has been harvested online (e.g. audiobooks, parliamentary speeches). First, the audio is decoded into a phoneme sequence by an off-theshelf phonetic recognizer in Hungarian. Phoneme sequences are then aligned to the normalized text transcripts through dynamic programming. Correspondence between phonemes and graphemes is done through a matrix of approximate sound-tographeme matching. Finally, the aligned data is split into short audio/text segments and the speech recognizer is trained using Kaldi toolkit. Alignment experiments performed for Catalan and Spanish show the feasibility to obtain accurate alignments that can be used to successfully train a speech recognizer.
Mild deprotection of carbapenem esters with aluminum trichloride (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMild deprotection of carbapenem esters with aluminum trichlorideMitsuaki Ohtani, Fumihiko Watanabe, and Masayuki NarisadaCite this: J. Org. Chem. 1984, 49, 26, 5271–5272Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/jo00200a058https://doi.org/10.1021/jo00200a058research-articleACS PublicationsRequest reuse permissionsArticle Views547Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
WINTERING HABITS OF SOME BIRDS AT THE NEVADA ATOMIC TEST SITE (1962)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Inhibiting Effects of Pyridine Homologues on the Anodic Oxidation of Methanol (1968)

燃料電池に使用したイオン交換膜の分解によって生成すると思われる含窒素化合物と関連して, ピリジン同族体をとり上げ, アルカリ溶液中, 白金電極上におけるメタノールのアノード酸化の抑制効果を三角波ポテンシオメトリーによって調べた。メタノールの酸化電流はピリジン濃度が高くなるにつれて減少し, ピリジンが10-3mol/l 存在していても非常に影響された。この抑制効果はピリジンが優先的に電極上に吸着してメタノールの吸着の活性点をふさぐためである。この種の抑制効果の大きさは次の順序であった。すなわち, 2, 6 - ジメチルピリジン< 2 - エチルピリジン≒ 2 - クロルピリジン< 2 - メチルピリジン≪ ピリジン< 3 - メチルピリジン< 4 - メチルピリジン。これらの結果はピリジン同族体の窒素原子の周囲における電子密度の変化と窒素原子におよぼす立体効果とから説明された。
Quinazoline Derivatives.<sup>1</sup> II. Synthesis of 4-(4'-Diethylamino-1'-methylbutyl-amino)-6-methoxyquinazoline (SN 12,253)<sup>2</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuinazoline Derivatives.1 II. Synthesis of 4-(4'-Diethylamino-1'-methylbutyl-amino)-6-methoxyquinazoline (SN 12,253)2Martha E. Smith, Elise Elisberg, and Mary L. SherrillCite this: J. Am. Chem. Soc. 1946, 68, 7, 1301–1303Publication Date (Print):July 1, 1946Publication History Published online1 May 2002Published inissue 1 July 1946https://pubs.acs.org/doi/10.1021/ja01211a056https://doi.org/10.1021/ja01211a056research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Second primary tumors in patients with head and neck squamous cell carcinoma (1995)

Second primary tumors in the head and neck of patients with cancer are not uncommon. If the second tumor occurs in the head and neck region, the prognosis is reasonably good.
A Phase II, Randomized, Open-Label, Multi-arm Study of TAS-115 for Castration-Resistant Prostate Cancer Patients With Bone Metastases (2021)

TAS-115 appears to demonstrate anti-tumor activity and acceptable tolerability in CRPC patients with bone metastases.
Self-assembled single wall carbon nanotube field effect transistors (2004)

We report detailed characterization of in-situ wired single wall carbon nanotube (SWNT) field effect transistors (FETs). They were batch processed using a single step technique based on hot filament chemical vapor deposition. Raw samples show an ambipolar field effect. The temperature dependence of the gain confirms the presence of Schottky barriers at the nanotube/metal interface. Moreover the gate dependence exhibits hysteresis at any temperature due to extraction and trapping of charges. Below 30 K, Coulomb blockade occurs at low drain-source bias and partially washes out the influence of the Schottky barriers.
Structure-activity relationships in tetramic acids and their copper (II) complexes. (1980)

3-Acetyl and 3-decanoyltetramic acids with various substituents at the 5-position and their copper complexes, which possess a tricarbonylmethane structure, were prepared and tested for antimicrobial activity. 3-Decanoyltetramic acid derivatives and their copper complexes inhibited the growth of Bacillus subtilis and Staphylococcus aureus, but did not inhibited the growth of gram-negative bacteria and molds. 3-(1-Iminoethyl)-tetramic acids and their copper complexes were synthesized and tested for inhibitory activity towards chlorophyll development in plants.
Characterization of virus-specific RNA synthesized in bovine cells infected with bovine viral diarrhea virus (1983)

Infection of bovine kidney cells with bovine viral diarrhea virus resulted in the synthesis of a single species of virus-specific RNA. Electrophoresis of this RNA on agarose-urea and agarose-formaldehyde gels indicated that it had a molecular weight of 2.9 X 10(6), corresponding to 8,200 bases (8.2 kilobases). This 8.2-kilobase RNA was resistant to RNase A treatment at 1 microgram/ml but was digested at higher concentrations of RNase (10 micrograms/ml). Sedimentation on neutral sucrose gradients indicated that the majority of this RNA (98%) sedimented at 21S, with a small amount sedimenting at 33S. Sedimentation on formaldehyde-containing sucrose gradients resulted in the conversion of all of the RNA to the faster-sedimenting form. At no time after infection were we able to detect virus-specific RNA species of lower molecular weight than the 8.2-kilobase RNA. The implications of these findings with respect to the means of replication of various togaviruses are discussed.
Design and semantics of form and movement (2005)

Contemporary cognitive science and neuroscience offer us some rather precise insights into the mechanisms that are responsible for certain body movements. In this paper, we argue that this knowledge may be highly relevant to the design of meaningful movement and behavior, both from a theoretical and practical point of view. Taking the example of a leech, we investigate and identify the basic principles of "embodied movement" that govern the motion of this simple creature, and argue that the development and adoption of a design methodology that incorporates these principles right from the start, may be the best way forward, if one wants to realize and design movements with certain desirable characteristics.
Alternately Assembled Ultrathin Film of Silica Nanoparticles and Linear Polycations (1997)

Abstract Anionic silica nanoparticles were assembled with linear polycation by alternate adsorption technique. Regular growth and surface smoothness of the films were confirmed by QCM and SEM, respectively.
Highly Enantioselective Copper‐Phosphoramidite‐Catalyzed Conjugate Addition of Dialkylzinc Reagents to Acyclic α,β‐Unsaturated Imides (2006)

Abstract A new and practical way to introduce an alkyl fragment in the β‐position of aliphatic carboxylic acid derivatives with high enantioselectivities by the use of a commercially available chiral ligand is reported. N ‐Acylpyrrolidinones, as simple derivatives of an α,β‐unsaturated carboxylic acid, were found to be the substrates of choice featuring good reactivity and high enantioselectivities (up to >99% ee).
A thermoacidophilic endoglucanase (CelB) from <i>Alicyclobacillus acidocaldarius</i> displays high sequence similarity to arabinofuranosidases belonging to family 51 of glycoside hydrolases (2003)

A 100-kDa protein with endoglucanase activity was purified from Triton X-100 extract of cells of the thermoacidophilic Gram-positive bacterium Alicyclobacillus acidocaldarius. The enzyme exhibited activity towards carboxy methyl cellulose and oat spelt xylan with pH and temperature optima of 4 and 80 degrees C, respectively. Cloning and nucleotide sequence analysis of the corresponding gene (celB) revealed an ORF encoding a preprotein of 959 amino acids which is consistent with an extracellular localization. Purified recombinant CelB and a variant lacking the C-terminal 203 amino acid residues (CelBtrunc) displayed similar enzymatic properties as the wild-type protein. Analysis of product formation suggested an endo mode of action. Remarkable stability was observed at pH values between 1 and 7 and 60% of activity were retained after incubation for 1 h at 80 degrees C. CelB displayed homology to members of glycoside hydrolase family 51, being only the second entry with activity typical of an endoglucanase but lacking activity on p-nitrophenyl-alpha-l-arabinofuranoside (pNPAraf). Highest sequence similarity was found towards the other endoglucanase F from Fibrobacter succinogenes (EGF), forming a distinct group in the phylogenetic tree of this family. Analysis of the amino acid composition of the catalytic domains demonstrated that CelB contains fewer charged amino acids than its neutrophilic counterparts, which is in line with adaptation to low pH. Wild-type and full-length recombinant CelB were soluble only in Triton X-100. In contrast, CelBtrunc was completely water soluble, suggesting a role of the C-terminal region in cell association. This C-terminal hydrophobic region displayed local sequence similarities to an alpha-amylase from the same organism.
Generation of Products and Quotients Using Approximate Binary Logarithms for Digital Filtering Applications (1970)

An approximate method for rapid multiplication or division with relatively simple digital circuitry is described. The algorithm consists of computing approximate binary logarithms, adding or subtracting the logarithms, and computing the approximate anti- logarithm of the resultant. Using a criteria of minimum mean square error, coefficients for the approximations are developed. An error analysis is given for three cases in which the algorithm is useful. Finally, applications to digital filtering computations are considered which illustrate that log-antilog multiplication is not simpler than an array multiplier for computing single products, but is useful for parallel digital filter banks and multiplicative digital filters.
Automatic Creation of Knowledge Graphs from Digital Musical Document Libraries (2014)

Comunicació presentada a la 9th Conference on Interdisciplinary Musicology (CIM14), celebrada els dies 4 a 6 de desembre de 2014 a Berlín, Alemanya.
Thermal Chemistry of Bicyclo[4.2.0]oct-2-enes (2006)

At 300 degrees C, bicyclo[4.2.0]oct-2-ene (1) isomerizes to bicyclo[2.2.2]oct-2-ene (2) via a formal [1,3] sigmatropic carbon migration. Deuterium labels at C7 and C8 were employed to probe for two-centered stereomutation resulting from C1-C6 cleavage and for one-centered stereomutation resulting from C1-C8 cleavage, respectively. In addition, deuterium labeling allowed for the elucidation of the stereochemical preference of the [1,3] migration of 1 to 2. The two possible [1,3] carbon shift outcomes reflect a slight preference for migration with inversion rather than retention of stereochemistry; the si/sr product ratio is approximately 1.4. One-centered stereomutation is the dominant process in the thermal manifold of 1, with lesser amounts of fragmentation and [1,3] carbon migration processes being observed. All of these observations are consistent with a long-lived, conformationally promiscuous diradical intermediate.
Gene Therapy Approaches to Ataxias (2009)

Gene therapy has been a clinical possibility since 1989 and the steadily increasing number of clinical trials now includes strategies targeting neurodegenerative conditions such as lysosomal storage disease, multiple sclerosis, Alzheimer's and, Parkinson's disease. In spite of lack of knowledge of the molecular causes of these diseases, results so far in these trials have been promising. Thus there is gaining confidence in the potential to develop effective treatments based on gene transfer for neurological diseases in the near future. Furthermore, the accelerating progress in knowledge of the molecular pathologies of neurogenetic disorders, including rare diseases such as the ataxias, makes them even more amenable to gene therapy. Here we review recent preclinical studies relevant to gene therapy of ataxias and discuss developments needed to bring these strategies into the clinic.
Reciprocal Recommendation System for Online Dating (2015)

Online dating sites have become popular platforms for people to look for potential romantic partners. Different from traditional user-item recommendations where the goal is to match items (e.g., books, videos, etc) with a user's interests, a recommendation system for online dating aims to match people who are mutually interested in and likely to communicate with each other. We introduce similarity measures that capture the unique features and characteristics of the online dating network, for example, the interest similarity between two users if they send messages to same users, and attractiveness similarity if they receive messages from same users. A reciprocal score that measures the compatibility between a user and each potential dating candidate is computed and the recommendation list is generated to include users with top scores. The performance of our proposed recommendation system is evaluated on a real-world dataset from a major online dating site in China. The results show that our recommendation algorithms significantly outperform previously proposed approaches, and the collaborative filtering-based algorithms achieve much better performance than content-based algorithms in both precision and recall. Our results also reveal interesting behavioral difference between male and female users when it comes to looking for potential dates. In particular, males tend to be focused on their own interest and oblivious towards their attractiveness to potential dates, while females are more conscientious to their own attractiveness to the other side of the line.
Mutations in the thymidine kinase gene that allow expression of the enzyme in quiescent (G0) cells. (1991)

Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of serum, TK mRNA, activity and polypeptide increase coordinately after about 10-15 h, at the beginning of S phase. When growth-independent heterologous promoters are substituted for the natural TK promoter, TK mRNA can be expressed in quiescent cells. Despite the presence of TK mRNA in such G0 cells, there is little expression of TK polypeptide; the normal increase in enzyme at S phase is observed following serum stimulation. Deletion of the introns and 3' untranslated sequences does not affect the expression of the TK gene in serum stimulation experiments. In contrast, deletion of the C-terminal 40 amino acids or fusion of a small segment of a beta-galactosidase to the C-terminus overcomes the block to expression of the TK polypeptide in G0 cells. These C-terminal alterations are the same as those which lead to constitutive expression of TK during the cell cycle of proliferating cells, suggesting that mechanisms which control the levels of TK in cycling cells may also operate in quiescent cells.
Multi-threaded Graph Partitioning (2013)

In this paper we explore the design space of creating a multi-threaded graph partitioner. We present and compare multiple approaches for parallelizing each of the three phases of multilevel graph partitioning: coarsening, initial partitioning, and uncoarsening. We also explore the differences in thread lifetimes and data ownership in this context. We show that despite the options for fine-grain synchronization and task decomposition offered by current threading technologies, the best performance is achieved by preserving data ownership and minimizing synchronization. In addition to this we also present an unprotected approach to generating a vertex matching in parallel with little overhead. We use these findings to develop an OpenMP based implementation of the Metis algorithms and compare it against MPI based partitioners on three different multi-core architectures. Our multi-threaded implementation not only achieves greater than a factor of two speedup over the other partitioners, but also uses significantly less memory.
Approaches to RF interference suppression for VHF/UHF synthetic aperture radar (2002)

An increasing amount of interest has developed in VHF/UHF SAR applications. Unfortunately the VHF-UHF portion of the spectrum is already in heavy use by other services, such as television and mobile communications. Even in remote locations the interference power often exceeds receiver noise by many dB, becoming the limiting factor on system sensitivity and severely degrading the image quality. This paper addresses the problem of radio frequency (RF) interference and its impact on SAR imagery. Several RF interference suppression methods are described and discussed. These include spectral estimation and coherent subtraction algorithms, as well as various filter approaches. The least-mean-squared (LMS) adaptive filter is described in detail, and its effectiveness in suppressing RF interference is demonstrated on simulated data and on real P-band data.