gebhart/patrepeval huggingface dataset:
Effect of extract from Salviae Miltiorrhizae Radix on uremic rats. (1986)

The effect of Salviae Miltiorrhizae Radix extract on blood constituents was investigated in rats made uremic by feeding an adenine-containing diet. Administration of Salviae Miltiorrhizae Radix extract for 18 d after feeding of the adenine diet for 6 d led to significant reductions of serum urea nitrogen, creatinine, methylguanidine, and guanidinosuccinic acid and an increase of guanidinoacetic acid, suggesting alleviation of the uremic state. In a group fed the adenine diet for 12 d, followed by the extract, there were significant decreases in urea nitrogen and guanidinosuccinic acid. However, the extract no longer caused any reduction of urea nitrogen, creatinine, methylguanidine, or guanidinosuccinic acid, or an increase of guanidinoacetic acid, when the adenine diet was given for 18 d to cause a more severely uremic state.
Remote Diode Shorting Improves Measurement of Soil Water by Time Domain Reflectometry (1992)

Abstract We describe a new time domain reflectometry (TDR) technique that increases the reliability of soil water content measurements. Remotely switched shorting diodes in combination with differential detection techniques greatly increase the effective amplitude of problem reflections and significantly reduce background noise. Reliable detection of the two reflections that define the apparent dielectric constant of soil was achieved in all laboratory and field conditions. This, for example, enables measurement of volumetric water content in saline or layered soils and allows the use of long connecting cables. Additionally, increased signal‐to‐noise ratios should allow the development of significantly less complex and expensive measurement systems. A three‐rod probe with a single diode was used to evaluate reflections from the air‐soil surface; reflected signal levels were increased 10:1 for short cables and 56:1 for a probe located at the end of a 100‐m cable. A three diode probe was employed to demonstrate performance in a simulated layered soil; the correct time of arrival of the reflection from the rod end was readily measured even though the reflection was attenuated by a factor of 2500:1. A strip‐line two‐segment probe was used to measure water content in two adjacent sand layers, providing a 23:1 signal‐to‐background noise ratio. For all these probes, waveform subtraction was used to remove virtually all background noise.
A Novel Method for Detection of the Transition Between Atrial Fibrillation and Sinus Rhythm (2010)

Automatic detection of atrial fibrillation (AF) for AF diagnosis, especially for AF monitoring, is necessarily desirable for clinical therapy. In this study, we proposed a novel method for detection of the transition between AF and sinus rhythm based on RR intervals. First, we obtained the delta RR interval distribution difference curve from the density histogram of delta RR intervals, and then detected its peaks, which represented the AF events. Once an AF event was detected, four successive steps were used to classify its type, and thus, determine the boundary of AF: 1) histogram analysis; 2) standard deviation analysis; 3) numbering aberrant rhythms recognition; and 4) Kolmogorov-Smirnov (K-S) test. A dataset of 24-h Holter ECG recordings (n = 433) and two MIT-BIH databases (MIT-BIH AF database and MIT-BIH normal sinus rhythm (NSR) database) were used for development and evaluation. Using the receiver operating characteristic curves for determining the threshold of the K-S test, we have achieved the highest performance of sensitivity and specificity (SP) (96.1% and 98.1%, respectively) for the MIT-BIH AF database, compared with other previously published algorithms. The SP was 97.9% for the MIT-BIH NSR database.
A study of shock mitigating materials in a split Hopkinson bar configuration. Phase 1 (1998)

Sandia National Laboratories (SNL) designs mechanical systems with electronics that must survive high shock environments. These mechanical systems include penetrators that must survive soil, rock, and ice penetration, nuclear transportation casks that must survive transportation environments, and laydown weapons that must survive delivery impact of 125 fps. These mechanical systems contain electronics that may operate during and after the high shock environment and that must be protected from the high shock environments. A study has been started to improve the packaging techniques for the advanced electronics utilized in these mechanical systems because current packaging techniques are inadequate for these more sensitive electronics. In many cases, it has been found that the packaging techniques currently used not only do not mitigate the shock environment but actually amplify the shock environment. An ambitious goal for this packaging study is to avoid amplification and possibly attenuate the shock environment before it reaches the electronics contained in the various mechanical systems. As part of the investigation of packaging techniques, a two phase study of shock mitigating materials is being conducted. The purpose of the first phase reported here is to examine the performance of a joint that consists of shock mitigating material sandwiched in between steel and to compare the performance of the shock mitigating materials. A split Hopkinson bar experimental configuration simulates this joint and has been used to study the shock mitigating characteristics of seventeen, unconfined materials. The nominal input for these tests is an incident compressive wave with 50 fps peak (1,500 {micro}{var_epsilon} peak) amplitude and a 100 {micro}s duration (measured at 10% amplitude).
Suppression of the Protein Tyrosine Phosphatase LAR Reduces Apolipoprotein B Secretion by McA-RH7777 Rat Hepatoma Cells (1997)

Apolipoprotein B (apo B) secretion is reduced by insulin in rat hepatocytes. To evaluate possible mechanisms by which insulin action leads to inhibition of apo B secretion, we evaluated the effect of suppression of the protein-tyrosine phosphatase LAR on apo B secretion by McA-RH7777 (McA) rat hepatoma cells. A reduction in cellular LAR levels was accomplished by stable transfection of McA cells with LAR antisense cDNA. Previous studies indicate that LAR-antisense transfectants demonstrate increased insulin receptor signaling. In current studies, reduced LAR expression results in a 60% to 70% reduction in apo B secretion compared with null vector control. The reduction in apo B secretion correlated with a significant decrease in cellular apo B mRNA levels. Results suggests there is a relationship of protein tyrosine phosphorylation with regulation of apo B mRNA abundance in McA cells.
Copper-Catalyzed Cross-Coupling and Carbonylative Cross-Coupling of Organostannanes and Organoboranes with Hypervalent Iodine Compounds (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCopper-Catalyzed Cross-Coupling and Carbonylative Cross-Coupling of Organostannanes and Organoboranes with Hypervalent Iodine CompoundsSuk-Ku Kang, Tokutaro Yamaguchi, Tae-Hyun Kim, and Pil-Su HoView Author Information Department of Chemistry, Sung Kyun Kwan University, Natural Science Campus, Suwon 440-746, KoreaCite this: J. Org. Chem. 1996, 61, 26, 9082–9083Publication Date (Web):December 27, 1996Publication History Received31 October 1996Published online27 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo962033whttps://doi.org/10.1021/jo962033wrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views2172Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cross coupling reaction,Inorganic carbon compounds,Ketones,Oxides,Salts Get e-Alerts
Real-time large-scale dense RGB-D SLAM with volumetric fusion (2014)

We present a new simultaneous localization and mapping (SLAM) system capable of producing high-quality globally consistent surface reconstructions over hundreds of meters in real time with only a low-cost commodity RGB-D sensor. By using a fused volumetric surface reconstruction we achieve a much higher quality map over what would be achieved using raw RGB-D point clouds. In this paper we highlight three key techniques associated with applying a volumetric fusion-based mapping system to the SLAM problem in real time. First, the use of a GPU-based 3D cyclical buffer trick to efficiently extend dense every-frame volumetric fusion of depth maps to function over an unbounded spatial region. Second, overcoming camera pose estimation limitations in a wide variety of environments by combining both dense geometric and photometric camera pose constraints. Third, efficiently updating the dense map according to place recognition and subsequent loop closure constraints by the use of an ‘as-rigid-as-possible’ space deformation. We present results on a wide variety of aspects of the system and show through evaluation on de facto standard RGB-D benchmarks that our system performs strongly in terms of trajectory estimation, map quality and computational performance in comparison to other state-of-the-art systems.
An improvement in reflow performance of plastic packages (2002)

The influence of die pad design and die attach adhesive on the resistance of a thin small out line package (TSOP) to reflow cracking has been investigated. Mechanisms of reflow cracking were studied using scanning acoustic tomography (SAT) and scanning electron micrography (SEM). For more precise analysis, computational calculations of stress were conducted. In the case of dimpled die pad, an experimental die adhesive with lower moisture absorption and higher adhesion strength showed excellent resistance to reflow cracking, resulting in crack-free performance in level I preconditioning tests. However,packages with the slot lead frame failed in level I preconditioning tests. The failure was due to the interfacial delamination between the bottom surface of die and the epoxy molding compound (EMC). SAT showed that the delamination initiated at the periphery of the slot during temperature cycling in preconditioning. During the subsequent soaking and IR reflow, moisture condensed at the delaminated interface generated the high vapour pressure that exceeded the fracture strength of the EMC. In other words, the interfacial integrity between the bottom surface of die and the molding compound is critical to the reflow cracking in packages with slot lead frame.
Reconstruction of scene models from sparse 3D structure (2002)

In this paper we present a geometric theory for reconstruction of surface models from sparse 3D data captured from N camera views which are consistent with the data visibility. Sparse 3D measurements of real scenes are readily estimated from image sequences using structure-from-motion techniques. Currently there is no general method for reconstruction of 3D models of arbitrary scenes from sparse data. We introduce an algorithm for recursive integration of sparse 3D structure to obtain a consistent model. This algorithm is shown to converge to the real scene structure as the number of views increases and to have a computational cost which is linear in the number of views. Results are presented for real and synthetic image sequences which demonstrate correct reconstruction for scenes containing significant occlusions.
Pharmacological Unmasking Microarray Approach-Based Discovery of Novel DNA Methylation Markers for Hepatocellular Carcinoma (2012)

DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. To find novel DNA methylation markers in hepatocellular carcinoma (HCC), we performed pharmacological unmasking (treatment with 5-aza-2'-deoxycytidine or trichostatin A) followed by microarray analysis in HCC cell lines. Of the 239 promoter CpG island loci hypermethylated in HCC cell lines (as revealed by methylation-specific PCR), 221 loci were found to be hypermethylated in HCC or nonneoplastic liver tissues. Thirty-three loci showed a 20% higher methylation frequency in tumors than in adjacent nonneoplastic tissues. Correlation of individual cancer-related methylation markers with clinicopathological features of HCC patients (n = 95) revealed that the number of hypermethylated genes in HCC tumors was higher in older than in younger patients. Univariate and multivariate survival analysis revealed that the HIST1H2AE methylation status is closely correlated with the patient's overall survival (P = 0.022 and P = 0.010, respectively). In conclusion, we identified 221 novel DNA methylation markers for HCC. One promising prognostic marker, HIST1H2AE, should be further validated in the prognostication of HCC patients.
Acute and Chronic Pulmonary Emboli: Angiography–CT Correlation (2006)

CT and angiography have complementary roles in the accurate diagnosis of acute and chronic thromboembolic disease. Conventional angiography should be used as a problem-solving technique after CT angiography has been performed because CT angiography is less invasive.
Development of a hybrid flywheel/battery drive system for electric vehicle applications (1977)

Today's electric vehicles are severely limited in multistop and go driving range and accelerating capability by the lead acid battery's inability to handle high power peaks while maintaining maximum energy storage capability. A hybrid flywheel/battery system can be used to isolate the battery from the accelerating power peaks, and should recover a substantial part of the braking energy. This paper describes the development of a small, high speed, lightweight flywheel/ ac synchronous motor alternator sealed energy storage package coupled into the battery and dc drive motor system through a simple rectifier/inverter power circuit. This system stores just enough energy in the rotor of the machine for one start-stop cycle. Provision is made to add a flywheel to store energy for several cycles, or enough energy for climbing or descending long grades. The fields of the two machines are electronically controlled to achieve optimum performance and effective energy utilization.
Polyclonal activation of the murine immune system by an antibody to IgD III. Ontogeny (1983)

It has recently been demonstrated that the injection of adult mice with an affinity-purified goat antibody to mouse IgD (GaM delta) stimulates activation of the humoral immune system that resembles, on a polyclonal level, specific B cell activation by a T cell-dependent antigen. One to 2 days after adult BALB/c mice are injected with 200 micrograms of GaM delta, their splenic B lymphocytes undergo a series of T-independent activation steps that include increases in surface (s) Ia expression, cell size and DNA synthesis. Seven days after GaM delta injection, these cells undergo T-dependent activation steps, that include further proliferation as well as differentiation into IgG1-secreting cells. We have now studied the ontogeny of the T-independent (day 2) and T-dependent (day 7) activation steps by injecting 100-200 micrograms of GaM delta into 3-day- to 10-week-old BALB/c mice. GaM delta failed to induce increases in B cell sIa expression or size 2 days after injection of mice 2 weeks old or younger and failed to stimulate increased DNA synthesis 2 days after injection of 4-week-old mice. In contrast, increases in spleen cell sIa expression, size and DNA synthesis were seen 7 days after injection of 6- to 8-day-old mice. Furthermore, increases in the numbers of spleen cells with large amounts of intracytoplasmic IgG1 were seen at the same time, although these increases were much less than were seen in GaM delta-treated adult mice. Thus, the ability of GaM delta to induce T help and to act in concert with such help to stimulate B cell proliferation and differentiation precedes in ontogeny the ability of GaM delta to directly induce B cell proliferation and early differentiative events. In addition, the early activating events that we have studied are not required for T-dependent B cell proliferation and antibody production to occur, although they appear to contribute to the magnitude of clonal expansion and antibody production.
Orthokeratology: part I historical perspective. (1982)

This history of orthokeratology includes contributions made by Jessen, Ziff, Nolan, Paige, Gates, May, Grant, Fontana, Tabb, Freeman, Shed, Kerns, and Binder to the use of contact lenses for myopia reduction. It reviews the early use of extremely flat lenses to flatten corneas and the more recent use of lenses fit with apical clearance to reduce myopia. The controlled studies of Kerns and Binder are described and the need for further research is indicated.
A Focused-Beam Type Laser Interferometric Dilatometer (1975)

Using a laser beam focused near interferometer plates, an improved interferometric dilatometer has been developed. It has a couple of features, i.e. it has a much greater latitude in parallelism adjustment of the interferometer plates than that of the conventional Fizeau-type ones and enables, on the other hand, automatic recording with a simple device just composed of a solar cell and a recorder to measure reflected beams. Moreover, collimation of the optical system is very easy. Therefore, it is applicable even to routine determination of dilatation for quality control in a factory. The dilatometer is capable of determining the thermal dilatation of materials with low and/or negative expansion as well as those with transition, extremum or inflection point in expansion curves. Experimental results on some metallic, ceramic, semiconductor and glassy materials are presented.
bioPrint (2014)

We propose an automatic deposition method of bacteria spores, which deform thin soft materials under environmental humidity change. We describe the process of two-dimensional printing the spore solution as well as a design application. This research intends to contribute to the understanding of the control and pre-programming the transformation of future interfaces.
Digital Preshaping of Ultrasonic Signals: Equipment and Applications (1982)

This p aper describes an a rrangement that uses AD and DA conversion and a computer in order to preshape a transmitted ultrasonic wave. Normally the ultrasonic transducer is excited by a very short e lectrical pulse. Using a DAC, the ultrasonic transducer can be excited by any desired waveform e g the digitally determined inverse filter, chirp signals etc. The desired excitation waveform is stored in a high speed memory. It is shifted out via the DAC to an amplifier and thence to the transducer. The ADC, which is triggered by the DAC equipment, converts one sample per sweep into 12 bits. Therefore, actual sample rate is low. But the virtual sample rate limited by the sample and hold circuit can reach 15 MHz. The ADC and DAC are connected to a microcomputer system that determines the desired excitation waveform. Various waveforms can be stored and it is then possible to change the excitation waveforms interactively during clinical examinations.
High-Throughput Measurement of <sup>41</sup>Ca by Accelerator Mass Spectrometry to Quantitate Small Changes in Individual Human Bone Turnover Rates (2004)

Biochemical markers of bone turnover suffer from large analytical and natural fluctuations (20-30%), making small differences in bone resorption impossible to resolve. This limits the clinical utility of such markers for individuals with the skeletal complications associated with many disease states (e.g., metastatic cancer, renal failure, osteoporosis). We are developing the capability to measure small changes (5-10%) in bone turnover rate in vivo by tagging the living skeleton with 41 Ca. Among the stable and radioactive calcium isotopes, only 41 Ca is useful for direct quantitation of bone turnover because it is extremely rare in nature and radiologically benign (10 5 years half-life, pure electron capture decay). The ratio of this tracer to total calcium remains quantifiable in body fluids and excreta via accelerator mass spectrometry (AMS) for many years following a single physiological-sized oral or intravenous dose. The highly automated AMS instrumentation and streamlined sample preparation allows a single operator to prepare or run more than 100 samples per day—significantly more than other 41 Ca programs worldwide. We intend to exploit these measurements for earlier diagnosis of pathological processes and interactive intervention with therapeutic agents, allowing modulation of these agents to obtain the best individual result for a patient.
Randomized Clinical Trial of a Sustained-Exposure Ciprofloxacin for Intratympanic Injection During Tympanostomy Tube Surgery (2015)

Results of this first clinical trial suggest that OTO-201 was well tolerated and shows preliminary clinical activity in treating tympanostomy tube otorrhea.
SciHadoop (2011)

Hadoop has become the de facto platform for large-scale data analysis in commercial applications, and increasingly so in scientific applications. However, Hadoop's byte stream data model causes inefficiencies when used to process scientific data that is commonly stored in highly-structured, array-based binary file formats resulting in limited scalability of Hadoop applications in science. We introduce Sci-Hadoop, a Hadoop plugin allowing scientists to specify logical queries over array-based data models. Sci-Hadoop executes queries as map/reduce programs defined over the logical data model. We describe the implementation of a Sci-Hadoop prototype for NetCDF data sets and quantify the performance of five separate optimizations that address the following goals for several representative aggregate queries: reduce total data transfers, reduce remote reads, and reduce unnecessary reads. Two optimizations allow holistic aggregate queries to be evaluated opportunistically during the map phase; two additional optimizations intelligently partition input data to increase read locality, and one optimization avoids block scans by examining the data dependencies of an executing query to prune input partitions. Experiments involving a holistic function show run-time improvements of up to 8x, with drastic reductions of IO, both locally and over the network.
Production of Cellulase enzyme by submerged fermentation process from Penicillium variabile (2011)

IJAR - Indian Journal of Applied Research (IJAR) IJAR is a double reviewed monthly print journal that accepts research works from scholars, academicians, professors, doctorates, lecturers, and corporate in their respective expertise of studies.
Autoimmune Epilepsy (2012)

When clinical and serological clues suggest an autoimmune basis for medically intractable epilepsy, early-initiated immunotherapy may improve seizure outcome.