gebhart/patrepeval huggingface dataset:
Regulation of Ste7 Ubiquitination by Ste11 Phosphorylation and the Skp1-Cullin-F-box Complex (2003)

Ste7 is a mitogen-activated protein kinase kinase that mediates pheromone signaling in Saccharomyces cerevisiae. We showed previously that Ste7 is ubiquitinated upon prolonged stimulation by pheromone and that accumulation of ubiquitinated Ste7 results in enhanced transcription and cell division arrest responses (Wang, Y., and Dohlman, H. G. (2002) J. Biol. Chem. 277, 15766-15772). We now report that ubiquitination of Ste7 requires Ste11 kinase and Skp1/Cullin/F-box (SCF) ubiquitin-conjugating activities. Ste7 is not ubiquitinated in Ste11-deficient cells or when the Ste11 phosphorylation sites have been mutated. Ste7 ubiquitination and degradation (but not phosphorylation) is specifically blocked in mutants defective for the E2 ubiquitin-conjugating enzyme Cdc34 or the cullin homologue Cdc53. Both are components of the SCF complex that ubiquitinates proteins during the G1-S transition of the cell cycle. Our findings suggest that SCF promotes the ubiquitination and degradation of Ste7, thereby favoring the resumption of cell division cycling after pheromone-induced growth arrest.
A purely elastic instability in Taylor–Couette flow (1990)

A non-inertial (zero Taylor number) viscoelastic instability is discovered for Taylor–Couette flow of dilute polymer solutions. A linear stability analysis of the inertialess flow of an Oldroyd-B fluid (using both approximate Galerkin analysis and numerical solution of the relevant small-gap eigenvalue problem) show the growth of an overstable (oscillating) mode when the Deborah number exceeds f ( S ) ε −½ , where ε is the ratio of the gap to the inner cylinder radius, and f ( S ) is a function of the ratio of solvent to polymer contributions to the solution viscosity. Experiments with a solution of 1000 p.p.m. high-molecular-weight polyisobutylene in a viscous solvent show an onset of secondary toroidal cells when the Deborah number De reaches 20, for ε of 0.14, and a Taylor number of 10 −6 , in excellent agreement with the theoretical value of 21. The critical De was observed to increase as ε decreases, in agreement with the theory. At long times after onset of the instability, the cells become small in wavelength compared to those that occur in the inertial instability, again in agreement with our linear analysis. For this fluid, a similar instability occurs in cone-and-plate flow, as reported earlier. The driving force for these instabilities is the interaction between a velocity fluctuation and the first normal stress difference in the base state. Instabilities of the kind that we report here are likely to occur in many rotational shearing flows of viscoelastic fluids.
Gemfibrozil decreases autoantibodies against oxidized low‐density lipoprotein in men with combined hyperlipidaemia (1998)

The beneficial effect of gemfibrozil in reducing CHD may at least in part depend on a decrease of the rate of LDL oxidation in vivo.
Mucosal Immune Response to Poliovirus Vaccines in Childhood (1984)

Comparative evaluation of the systemic and secretory antibody response to live attenuated (oral) poliovirus vaccine ( OPV ) or inactivated poliovirus vaccine (IPV) has suggested that both vaccines are highly effective in inducing seroconversion and in preventing paralytic poliomyelitis. However, parenteral immunization with IPV does not appear to be highly effective in inducing secretory antibody response in the nasopharynx or alimentary tract during primary immunization. Reimmunization with IPV in subjects previously primed with parenterally administered IPV appears to result in a mild booster effect on the development of secretory antibody response. More significantly, rechallenge by the oral route with OPV in IPV-primed subjects resulted in a marked enhancement of secretory antibody response. In general, no suppression of systemic or secretory response to poliovirus was observed with either form ( OPV vs. IPV) or with route of immunization. These observations are discussed in relation to the immune response observed with other mucosally or parenterally administered antigens. Their implications in the development of oral tolerance are briefly reviewed.
Clinical and technical evaluation of ACS BR serum assay of MUC1 gene-derived glycoprotein in breast cancer, and comparison with CA 15-3 assays. (1997)

The mucin glycoprotein-detecting assay CA 15-3 is a valuable tool for monitoring the course of disease in breast cancer patients. Assays of CA 15-3 are based on the use of two MAbs to polymorphic epithelial mucin (PEM). We evaluated the technical and clinical performance of the Chiron ACS BR, an automated competitive chemiluminescence assay using a single MAb, B27.29, and compared the assay's results with those of the Centocor CA 15-3 RIA, the Abbott IMx CA 15-3, and the Boehringer Mannheim Enzymun-Test CA 15-3. The study population consisted of 253 healthy women, 66 patients with benign breast disease, 168 breast cancer patients, and 76 patients with other carcinomas. In the technical evaluation, we assessed the precision and linearity on dilution of the ACS BR assay. Cutoff values (upper limits of values seen in healthy subjects) were determined for all four assays. Agreement between the assays was studied by linear regression analysis. The ACS BR assay gave within- and between-assay CVs of 2.2% and 3.9%, respectively. Three samples from healthy women gave discordant values by ACS BR and were not included in the calculations. All four assays exhibit a highly similar pattern when monitoring breast cancer disease; the closest agreement of values was obtained between ACS BR and Centocor CA 15-3. We conclude that the ACS BR assay is a fast and reliable immunoassay for measuring PEM in serum. Although it detects a slightly different epitope on the PEM molecule than is targeted in other assays, for cancer serum samples it agreed better with the original Centocor CA 15-3 assay than did the other two CA 15-3 assays tested.
Demonstration of Antigenic and Genotypic Variation in <i>Orientia tsutsugamushi</i> Which Were Isolated in Japan, and Their Classification into Type and Subtype (1996)

A total of 40 strains of Orientia tsutsugamushi (34 isolates from patients and trombiculid mites in Japan, and 6 prototype strains of antigenic variants) were examined for classification based on the reactivities with type-specific monoclonal antibodies in indirect immunofluorescence tests, and on the restriction fragment length polymorphism of a polymerase chain reaction (PCR)-amplified 56-kilodalton type-specific antigenic protein gene. By these methods, several antigenic and genotypic variants were found among the strains, and these variants were classified into types and further into subtypes. These results suggest that there are many variants in O. tsutsugamushi, and the methods used here seem to be useful for the systematic classification of the numerous variants. A strain which may be a new type distinguishable from those identified previously was also found in this study. Furthermore, variety in the degree of pathogenicity in mice related to type and/or subtype classification were observed.
In-Line Connectors for Multimode Optical Waveguide Bundles (1974)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Frank L. Thiel, Roy E. Love, and Rex L. Smith, "In-Line Connectors for Multimode Optical Waveguide Bundles," Appl. Opt. 13, 240-242 (1974) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Evidence That Intermittent Structured Treatment Interruption, but Not Immunization with ALVAC‐HIV vCP1452, Promotes Host Control of HIV Replication: The Results of AIDS Clinical Trials Group 5068 (2006)

In this randomized, controlled study of intermittent STI as a therapeutic autoimmunization strategy, evidence of enhanced immunologic control of HIV replication was demonstrated.
Macrophage-mediated myelin-related mitogenic factor for cultured Schwann cells. (1988)

Conditioned medium from cultured peritoneal macrophages that have phagocytosed a myelin membrane fraction is mitogenic for cultured Schwann cells. Production of the mitogenic supernatant was time- and dose-dependent with a maximal Schwann cell-proliferative response from supernatants after 48-hr incubation of cultured macrophages with myelin-enriched fraction (200 micrograms of protein per ml). The response was specific for myelin membrane: supernatants derived from macrophages incubated with axolemma, liver microsomes, polystyrene beads, or lipopolysaccharide were not mitogenic. Lysosomal processing of the myelin membrane was necessary for the production of the mitogenic factor, which was shown to be heat labile and trypsin sensitive. There was no species specificity because myelin membranes isolated from the central and peripheral nervous systems of rat, bovine, and human were equally potent in eliciting mitogenic supernatant. However, supernatants derived from central nervous system myelin membranes were two to three times more mitogenic than those obtained from peripheral nervous system fractions of the same species. Previous observations that myelin is mitogenic for cultured Schwann cells may, in part, involve the intermediate processing of myelin by macrophages that are present in Schwann cell cultures. These results suggest that macrophages play a crucial role in Schwann cell proliferation during Wallerian degeneration.
Analysis of the polyolefin/trialkylamine primer interface (1993)

Abstract Tertiary alkylamines of different chain lengths have been used as primers for adhesive bonding strength promotion for polyolefinic surfaces with cyanoacrylate (CA) adhesives. A combination of the construction of model polyolefin surfaces and advanced molecular‐sensitive analysis tools has been employed for understanding the promoter/polyolefin interaction at the interface. Characterization of primer structure and interfacial properties has been carried out using grazing angle reflection‐absorption Fourier transform infrared spectroscopy (GA/FTIR), ellipsometry, x‐ray photoelectron spectroscopy (XPS) and contact angle titration using different pH probe liquids. Our work has focused on the design and construction of a model polyolefin surface using a new in situ polyethylene (PE) polymerization technique to form a controllable thickness (<400 Å) of PE film on a reflective metal surface. The new technique of in situ PE polymerization is based on diazomethane chemistry. Both protonated and deuterated PE films have been successfully prepared. The results of spectroscopic investigations of these model deuterated and non‐deuterated PE surfaces are disclosed. Molecular parameters that affect adhesion promotion have been studied. The parameters studied include molecular structure and alkyl chain length of tertiary alkylamines.
Improved Complex Torque Coefficient Method Using CPCM for Multi-Machine System SSR Analysis (2014)

Calculation of the complex torque coefficient for multi-machine system subsynchronous resonance (SSR) assessment had been proven a hard task. In this paper the concept of complex frequency domain port-equivalence conductance matrix (CPCM) is introduced to model the individual system component which represents the relationship between the terminal voltage and current in frequency domain, and the model of the overall power system can be established easily. Thus the complex torque coefficients of the generator unit under investigation can be calculated for SSR assessment. The advantages of this proposed method are that it can take the shaft dynamics and the rotor angle interactions among the generator units into consideration for the multi-machine power system SSR analysis, as well as it can be used to analyze the effectiveness of SSR damping devices. The effectiveness of the proposed method has been verified by both the eigenvalue analysis and the time domain simulation.
Inflammatory arthritis: imaging of endothelial cell activation with an indium-111-labeled F(ab')2 fragment of anti-E-selectin monoclonal antibody. (1995)

Endothelial cell immunotargeting with a radiolabeled anti-E-selectin F(ab')2 monoclonal antibody is feasible for use in imaging of inflammation.
Molecular cloning and analysis of a cDNA coding for chorismate synthase from the higher plant Corydalis sempervirens Pers. (1991)

Chorismate synthase catalyzes the last common step in the biosynthesis of the three aromatic amino acids in microorganisms and plants. We have cloned a cDNA for this enzyme from the higher plant Corydalis sempervirens. This is the first chorismate synthase cDNA from a eukaryotic organism. The nucleotide sequence was determined and the identity of the cDNA was confirmed by the amino acid sequence of tryptic peptides obtained from purified chorismate synthase. The homology to the two known bacterial sequences is about 48%. The cDNA contains an open reading frame of 1341 base pairs, encoding a protein of 447 amino acids. This protein with a molecular mass of 48,100 daltons resembles a chorismate synthase precursor targeted for chloroplast import. Multiple sites of polyadenylation were observed in chorismate synthase mRNAs.
Forage crop species response to varying soil moisture stress during germination (2015)

A study was made to investigate the ability of 22 grasses and 11 legume species to germinate against a moisture stress in Manhattan fine sandy loam.The soil was adjusted to various moisture contents corresponding to 5, 9, 10-2/3, 12-1/2 and 15 atmospheres.A check was conducted at field capacity.When moisture content decreased, germination decreased.In a few species, germination was higher at 9 than at 5 atmospheres soil moisture tension.At the highest tension the order of decreasing ability to germinate against tension was found to be: Fairway crested wheatgrass, Intermediate wheatgrass, Standard crested wheatgrass, Nordan crested wheatgrass, Russian wildrye, Tall wheatgrass, Lincoln smooth bromegrass, Pubescent wheatgrass, Slender wheatgrass, Tualatin oatgrass, Alta fescue, Switch-grass, and Meadow foxtail.Other species did not germinate.It was observed that germination of legumes, in general, was depressed to a greater degree than the grasses.This was attributed to the fact that the cotelydons of the legumes pushing through the soil, caused a cracking of the soil surface, thus exposing the seed to the atmosphere.When the soil, in which species were subjected to moisture tension, was restored to field capacity, it was found that some species exhibited increased germination, some were not affected, and some showed a decrease in germination.Species which showed increased germination were: Standard crested wheatgrass, Russian wildrye, Strawberry clover, Western wheatgrass, Broadleaf birdsfoot trefoil, and Ruby Valley milkvetch.Species which were not affected were: Fairway crested wheatgrass, Tall wheatgrass, Intermediate wheatgrass, Pubescent wheatgrass, Lincoln smooth bromegrass, Timothy, Ranier red fescue, Whitmar beardless wheatgrass, Ladino clover, and Mandan wildrye.The remainder all showed decrease in germation.It was concluded that subsequent seed viability may be influenced when seed are exposed to conditions where moisture was not present in sufficient quantity to complete the germination phase.
A Scalable Topic-Based Open Source Search Engine (2004)

Site-based or topic-specific search engines work with mixed success because of the general difficulty of the information retrieval task, and the lack of good link information to allow authorities to be identified. We are advocating an open source approach to the problem due to its scope and need for software components. We have adopted a topic-based search engine because it represents the next generation of capability. This paper outlines our scalable system for site-based or topic-specific search, and demonstrates the developing system on a small 250,000 document collection of EU and UN web pages.
Liposomal drug delivery systems--clinical applications. (2005)

Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. As a result, numerous improvements have been made, thus making this technology potentially useful for the treatment of certain diseases in the clinics. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. The current pharmaceutical preparations of liposome-based therapeutic systems mainly result from our understanding of lipid-drug interactions and liposome disposition mechanisms. The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes that can be targeted on tissues, cells or intracellular compartments with or without expression of target recognition molecules on liposome membranes. This review is mainly focused on the diseases that have attracted most attention with respect to liposomal drug delivery and have therefore yielded most progress, namely cancer, antibacterial and antifungal disorders. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery.
Subliminal words durably affect neuronal activity (2007)

Unconscious mental representations elicited by subliminal stimuli are marked by their fleeting lifetimes, usually below 1 s. Can such evanescent subliminal stimuli, nevertheless, lead to long-lasting learning? To date, evidence suggesting a long-term influence of briefly perceived stimuli on behaviour or brain activity is scarce and questionable. In this study, we used intracranial recordings to provide the first direct demonstration that unconsciously perceived subliminal words could exert long-lasting effects on neuronal signals. When repeating subliminal words over long interstimulus intervals, we observed electrophysiological repetition effects. These unconscious repetition effects suggest that the single presentation of a masked word can durably affect neural architecture.
Maximizing MPI point-to-point communication performance on RDMA-enabled clusters with customized protocols (2009)

Message Passing Interface (MPI) point-to-point communications are usually realized with two protocols, the eager protocol for small messages and the rendezvous protocol for medium and large sized messages. Traditional sender-initiated rendezvous protocols are sub-optimal in many situations. In this work, we propose to refine the rendezvous protocol for medium and large messages on RDMA-enabled clusters with three protocols that are customized for different situations, a hybrid protocol for medium sized messages when the sender arrives early, a sender-initiated protocol for large messages when the sender arrives early, and a receiver-initiated protocol when the receiver arrives early. In comparison to traditional sender-initiated rendezvous protocols, the proposed scheme reduces unnecessary synchronizations, decreases the number of control messages that are in the critical path of communications, and improves the communication progress, which results in a significantly better communication-computation overlap capability. We present and analyze these protocols, and describe how these protocols and the eager protocol can be seamlessly integrated in one system without introducing an excessive number of control messages. We have implemented the proposed scheme for InfiniBand clusters. The experimental results demonstrate the effectiveness of the proposed technique.
Angiotensin II contributes to arterial compliance in congestive heart failure (2002)

Arterial compliance is determined by structural factors, such as collagen and elastin, and functional factors, such as vasoactive neurohormones. To determine whether angiotensin II contributes to decreased arterial compliance in patients with heart failure, this study tested the hypothesis that administration of an angiotensin-converting enzyme inhibitor improves arterial compliance. Arterial compliance and stiffness were determined by measuring carotid artery diameter, using high-resolution duplex ultrasonography, and blood pressure in 23 patients with heart failure secondary to idiopathic dilated cardiomyopathy. Measurements were made before and after intravenous administration of enalaprilat (1 mg) or vehicle. Arterial compliance was inversely related to both baseline plasma angiotensin II (r = -0.52; P = 0.015) and angiotensin-converting enzyme concentrations (r = -0.45; P = 0.041). During isobaric conditions, enalaprilat increased carotid artery compliance from 3.0 +/- 0.4 to 5.0 +/- 0.4 x 10(-10) N(-1). m(4) (P = 0.001) and decreased the carotid artery stiffness index from 17.5 +/- 1.8 to 10.1 +/- 0.6 units (P = 0.001), whereas the vehicle had no effect. Thus angiotensin II is associated with reduced carotid arterial compliance in patients with congestive heart failure, and angiotensin-converting enzyme inhibition improves arterial elastic properties. This favorable effect on the pulsatile component of afterload may contribute to the improvement in left ventricular performance that occurs in patients with heart failure treated with angiotensin-converting enzyme inhibitors.
Security proof for quantum key distribution using qudit systems (2010)

We provide security bounds against coherent attacks for two families of quantum key distribution protocols that use $d$-dimensional quantum systems. In the asymptotic regime, both the secret key rate for fixed noise and the robustness to noise increase with $d$. The finite key corrections are found to be almost insensitive to $d\ensuremath{\lesssim}20$.
Formation Control of Robotic Swarm Using Bounded Artificial Forces (2013)

Formation control of multirobot systems has drawn significant attention in the recent years. This paper presents a potential field control algorithm, navigating a swarm of robots into a predefined 2D shape while avoiding intermember collisions. The algorithm applies in both stationary and moving targets formation. We define the bounded artificial forces in the form of exponential functions, so that the behavior of the swarm drove by the forces can be adjusted via selecting proper control parameters. The theoretical analysis of the swarm behavior proves the stability and convergence properties of the algorithm. We further make certain modifications upon the forces to improve the robustness of the swarm behavior in the presence of realistic implementation considerations. The considerations include obstacle avoidance, local minima, and deformation of the shape. Finally, detailed simulation results validate the efficiency of the proposed algorithm, and the direction of possible futrue work is discussed in the conclusions.