gebhart/patrepeval huggingface dataset:
Immunoblot Analysis Using Epidermal Extract and 180kD Bullous Pemphigoid Antigen NC16a Domain in the Diagnosis of Subepidermal Bullous Diseases (2004)

Background: The 180kD bullous pemphigoid antigen (BPI80) is known to be recognized by sera from patients with bullous pemphigoid (BP), herpes gestationis (HG), and cicatricial pemphigoid (CP). A series of previous studies using BP180 recombinant proteins has shown that most sera from patients with BP and HG react with the NC16a domain of BP180. Objective: This study was performed to compare the immunoblotting results by using human epidermal extracts and by using recombinant protein of BP180 NC16a domain in the diagnosis of subepidermal bullous skin diseases. Method: We observed the reactivity with the epidermal extract of normal human foreskin and recombinant protein of BP180 NC16a domain in immunoblotting assay. Results: In immunoblotting with epidermal extract, 7(78%) and 6(67%) of the 9 BP sera reacted with BP230 and BP180, respectively. 1(50%) of the 2 HG and 2(100%) of the 2 CP sera reacted with BP180. In immunoblotting with recombinant protein of BP180 NC16a domain, 8(89%) of the 9 BP sera and 2(100%) of the 2 HG sera were immunoreactive. But, none of the CP and pemphigus sera reacted with the recombinant protein. Conclusion: The immunoblotting analysis using BP180 NC16a domain is a highly sensitive method without ambiguity in the diagnosis of subepidermal bullous skin diseases, and also is useful for the differential diagnosis of BP and HG from CP.
Robust Estimation of Message Importance Using Inferred Inter-recipient Trust for Supporting Email Triage (2010)

In recent years, the number of emails received by an individual has been increasing, and the time required for email triage (i.e., the process of going through unhandled emails and deciding what to do with them) has therefore been increasing. Golbeck et al. proposed TrustMail, which is a prototype email client that prioritizes emails in user's mailbox utilizing a trust network (i.e., a social network representing trust relationships among users). In this paper, we extend the notion of TrustMail to allow robust messagebased prioritization using inter-recipient trusts, which are (inferred) trust scores from the recipient to other recipients. We propose a method called EMIRT (Estimating Message Importance from inter-Recipient Trust) for enabling robust message prioritization. We also evaluate the effectiveness of our proposed EMIRT for estimating importance of emails through experiments utilizing a large email corpus called Enron Email Dataset. Consequently, we show that EMIRT realizes robust email prioritization.
A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication (2009)

Short interfering RNAs (siRNAs) have been used to inhibit HIV-1 replication. The durable inhibition of HIV-1 replication by RNA interference has been impeded, however, by a high mutation rate when viral sequences are targeted and by cytotoxicity when cellular genes are knocked down. To identify cellular proteins that contribute to HIV-1 replication that can be chronically silenced without significant cytotoxicity, we employed a shRNA library that targets 54,509 human transcripts. We used this library to select a comprehensive population of Jurkat T-cell clones, each expressing a single discrete shRNA. The Jurkat clones were then infected with HIV-1. Clones that survived viral infection represent moieties silenced for a human mRNA needed for virus replication, but whose chronic knockdown did not cause cytotoxicity. Overall, 252 individual Jurkat mRNAs were identified. Twenty-two of these mRNAs were secondarily verified for their contributions to HIV-1 replication. Five mRNAs, NRF1, STXBP2, NCOA3, PRDM2, and EXOSC5, were studied for their effect on steps of the HIV-1 life cycle. We discuss the similarities and differences between our shRNA findings for HIV-1 using a spreading infection assay in human Jurkat T-cells and results from other investigators who used siRNA-based screenings in HeLa or 293T cells.
Geographic Information System-Based Truck Accident Information and Management System for New Jersey Roadways (2002)

Geographic information systems (GIS) technology has been discussed for managing traffic accident data for years. However, its usefulness for analyzing truck accidents has not been explored extensively. Because GIS has spatial referencing and graphical display features, it would be useful to link relevant accident information to assist in information management and safety analysis. Used with other analysis technologies, GIS can help identify factors that contribute to accidents at specific locations and to identify countermeasures. The New Jersey Department of Transportation (NJDOT) has comprehensive electronic databases, including roadway networks, truck accident records, roadway geometry, and other relevant information, but use of this information remains at the level of database management. Integration of truck accident information into a GIS is a low-cost, high-benefit way to analyze factors that affect truck accidents and their associated mitigation measures. The analytical ability of a GIS-based truck accident information management system developed for NJDOT is presented.
Swallowing Function After Stroke (1999)

Swallowing function should be assessed in all acute stroke patients because swallowing dysfunction is common, it persists in many patients, and complications frequently arise. The assessment of swallowing function should be both clinical and videofluoroscopic. The clinical and videofluoroscopic features at presentation that are important predictors of subsequent swallowing abnormalities and complications are videofluoroscopic evidence of delayed oral transit, a delayed or absent swallow reflex, and penetration. These findings require validation in other studies.
Simulation of the Cyclic Operation of a PSA-based SEWGS Process for Hydrogen Production with CO2 Capture (2013)

A dynamic one-dimensional homogeneous model for multiple bed Sorption Enhanced Water Gas Shift (SEWGS) system has been developed in this work. The SEWGS system under consideration is based on a Pressure Swing Adsorption (PSA) process which operates in a cyclic manner. During the reaction/adsorption step, CO2 produced by Water Gas Shift (WGS) reaction is simultaneously adsorbed on a highly CO2-selective solid adsorbent and removed from the gas phase, enhancing the WGS reaction toward higher reaction conversion and hydrogen production. The periodic adsorption and desorption of CO2 is induced by a pressure swing cycle, and the cyclic capacity can be amplified by purging with steam. Simulation results enable tracking the operation of the system over sequence of steps. As it is expected, high levels of CO conversion and CO2 capture ratio are achieved by enhancing the equilibrium reaction of WGS with adsorbents. Moreover there is no need to reheat the hydrogen product before it enters the gas turbine due to operability of SEWGS system at high temperature of approximately 400 °C. Hydrogen production undergoes repeating fluctuations over cycle time which is associated with using part of the H2 product for repressurization step.
Tuning the refractive index in 3D direct laser writing lithography: towards GRIN microoptics (2015)

Abstract We report a study of the determination of polymer cross‐linking, namely the degree of conversion and refractive index of the microstructures created by two‐photon polymerization (TPP). The influence of TPP processing parameters such as laser intensity and scanning velocity is investigated. The degree of conversion is analyzed via Raman microspectroscopy and the refractive index is measured with the interferometric technique employing a Michelson interferometer. Moreover, the relationship between these two properties is revealed and details are discussed. The largest refractive index change that we have obtained is of the order of 10 −2 . Finally, we propose and demonstrate experimentally the realization of the gradient‐index (GRIN) structure, resulting from a laser‐induced local refractive index modification due to monomer cross‐linking, i.e. degree of conversion. This work implies that the TPP technique is a valuable tool for the fabrication of GRIN microoptics for (in)homogeneous molding of light flow at the micrometer scale. image
Novel opiates and antagonists. 5. 7-Carbethoxy-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-ones (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel opiates and antagonists. 5. 7-Carbethoxy-N-(cycloalkylmethyl)-3-hydroxymorphinan-6-ones and -isomorphinan-6-onesPatricia Herlihy, Haldean C. Dalzell, John F. Howes, and Raj K. RazdanCite this: J. Med. Chem. 1982, 25, 8, 986–990Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/jm00350a020https://doi.org/10.1021/jm00350a020research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ubiquitous Computing: Object Tracking and Monitoring in Construction Processes Utilizing ZIGBEE Networks (2006)

Ubiquitous Computing: Object Tracking and Monitoring in Construction Processes Utilizing ZIGBEE Networks Miroslaw J. Skibniewski, Won-Suk Jang Pages 287-292 (2006 Proceedings of the 23rd ISARC, Tokyo, Japan, ISBN 9784990271718, ISSN 2413-5844) Abstract: A large-scale of civil infrastructure systems is associated with great amounts of project resources and activities interoperated with various participants and organizations. Well-defined methodology for information acquisition and communication became more critical in the management of civil infrastructure than ever before. Rapidly emerging wireless sensor technology has been drawing a log of attention as a possible method to realize the ubiquitous computing environment in everyday life, and more advanced strategy for implementing ubiquitous interfaces between device and networks needs to be investigated in the application of civil infrastructure. This paper introduces the conceptual understanding and strategy of ZigBee networks to be deployed in the civil infrastructure systems. In addition, the prototype application for object tracking and monitoring system in construction site using ZigBee networks is proposed to provide an insight for the industrial practices in sensor- and network-based ubiquitous computing. Keywords: Ubiquitous computing, ZigBee sensor network, civil infrastructure, localization systems DOI: https://doi.org/10.22260/ISARC2006/0055 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Nonlinear optical processes in noncrystalline semiconductors (2002)

The paper summarizes the peculiarities of the nonlinear interaction of short laser pulses with the noncrystalline semiconductors (chalcogenide glasses, a-Si:H), showing that noncrystalline semiconductors (NS) are an interesting material for high speed optoelectronics. The physical mechanisms, which can contribute to the nonlinear light absorption in NS under pulsed excitation, are critically reviewed.
Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex (2003)

The transcription factor Snail has been described as a direct repressor of E-cadherin expression during development and carcinogenesis; however, the specific mechanisms involved in this process remain largely unknown. Here we show that mammalian Snail requires histone deacetylase (HDAC) activity to repress E-cadherin promoter and that treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Snail. Moreover, overexpression of Snail is correlated with deacetylation of histones H3 and H4 at the E-cadherin promoter, and TSA treatment in Snail-expressing cells reverses the acetylation status of histones. Additionally, we demonstrate that Snail interacts in vivo with the E-cadherin promoter and recruits HDAC activity. Most importantly, we demonstrate an interaction between Snail, histone deacetylase 1 (HDAC1) and HDAC2, and the corepressor mSin3A. This interaction is dependent on the SNAG domain of Snail, indicating that the Snail transcription factor mediates the repression by recruitment of chromatin-modifying activities, forming a multimolecular complex to repress E-cadherin expression. Our results establish a direct causal relationship between Snail-dependent repression of E-cadherin and the modification of chromatin at its promoter.
D-Aminoacid Oxidase and Homogentisate Oxygenase Activities in the Tumor Bearing Rats (1963)

Journal Article D-Aminoacid Oxidase and Homogentisate Oxygenase Activities in the Tumor Bearing Rats Get access YOZO NAKATA, YOZO NAKATA Institute for Cancer Research, Medical School, Osaka UniversityOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar FUMIO WADA, FUMIO WADA Institute for Cancer Research, Medical School, Osaka UniversityOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar SETSUO UCHIYAMA, SETSUO UCHIYAMA Institute for Cancer Research, Medical School, Osaka UniversityOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar YUKIYA SAKAMOTO YUKIYA SAKAMOTO Institute for Cancer Research, Medical School, Osaka UniversityOsaka Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 53, Issue 6, June 1963, Pages 505–507, https://doi.org/10.1093/oxfordjournals.jbchem.a127731 Published: 01 June 1963 Article history Received: 18 February 1963 Published: 01 June 1963
Selectivity in the Photodimerization of 6-Alkylcoumarins (2003)

Coumarin and 6-alkylcoumarins (alkyl = C(1) to C(16)) were photodimerized in homogeneous solvents differing in polarity and in aqueous micellar solutions. The four possible photodimers, syn head-to-head (hh), anti head-to-head, syn head-to-tail (ht), and anti head-to-tail, were identified through a combination of X-ray analysis and NMR spectroscopy. In 6-methylcoumarin the concentration-corrected dimerization (quantum) yield increases with decreasing concentration of the educt; anti-hh was formed exclusively in nonpolar solvents and upon triplet sensitization and was the main product under all conditions except for ionic micellar systems, which direct to preferred syn-hh dimerization. Long alkyl substituents, however, lead to anti-hh in polar solvents and in micelles, too. Predominating ht dimer formation was observed for nonsubstituted coumarin in polar solvents only. Thus, syn/anti and hh/ht selectivity can be steered by varying the 6-alkyl substituent. Syn-hh photodimers of 6-methylcoumarin can be photochemically split into the monomers; they partly proved thermally unstable against acids, bases, methanol, and on SiO(2) surfaces.
High Performance Computing for Hyperspectral Remote Sensing (2011)

Advances in sensor and computer technology are revolutionizing the way remotely sensed data is collected, managed and analyzed. In particular, many current and future applications of remote sensing in Earth science, space science, and soon in exploration science will require real- or near real-time processing capabilities. In recent years, several efforts have been directed towards the incorporation of high-performance computing (HPC) models to remote sensing missions. A relevant example of a remote sensing application in which the use of HPC technologies (such as parallel and distributed computing) is becoming essential is hyperspectral remote sensing, in which an imaging spectrometer collects hundreds or even thousands of measurements (at multiple wavelength channels) for the same area on the surface of the Earth. In this paper, we review recent developments in the application of HPC techniques to hyperspectral imaging problems, with particular emphasis on commodity architectures such as clusters, heterogeneous networks of computers, and specialized hardware devices such as field programmable gate arrays (FPGAs) and commodity graphic processing units (GPUs). A quantitative comparison across these architectures is given by analyzing performance results of different parallel implementations of the same hyperspectral unmixing chain, delivering a snapshot of the state-of-the-art in this area and a thoughtful perspective on the potential and emerging challenges of applying HPC paradigms to hyperspectral remote sensing problems.
Switched Causal Modeling of Transmission with Clutch in Hybrid Electric Vehicles (2006)

The modeling of a clutch in a powertrain transmission is a sensitive issue because of its non-linear behavior. Two different states have to be taken into account: clutch locked and slipping. Two different models are then used and a specific condition defines the commutation between both models with respect to the physical energy flow. An application to parallel hybrid electric vehicles (HEV) is then presented. Energetic macroscopic representation (EMR) is used to organize the numerous blocks required. A Petri net is employed to activate a model according to clutch state (lock and slip)
Review article: drug therapy for non‐alcoholic fatty liver disease (2005)

Non-alcoholic fatty liver disease represents a spectrum of liver diseases, characterized mainly by macrovesicular steatosis in the absence of significant alcohol ingestion. Non-alcoholic fatty liver disease includes both non-alcoholic fatty liver and non-alcoholic steatohepatitis. Non-alcoholic steatohepatitis once considered a benign process is now known to lead to progressive fibrosis and cirrhosis. Histologically indistinguishable from alcoholic liver disease, the exact aetiology of non-alcoholic fatty liver disease remains unknown, but the fundamental pathophysiological process appears to be insulin resistance and oxidative stress related to the metabolic syndrome. Therapy has focused on risk factors, weight reduction and pharmacological intervention. Promising pharmacological treatments have been demonstrated with antioxidants, insulin sensitizers, hepatoprotectants and lipid-lowering agents. However, without larger randomized studies, no pharmacological treatments can be recommended at this time.
Adiabatic Broadband Four-Wave Mixing Frequency Conversion in Optical Fibers (2018)

We find adiabatic four-wave mixing in optical fibers allows efficient, near-octave-spanning near-infrared to mid-infrared conversion. Simulations indicate several possible fiber platforms, extending one-to-one broadband frequency conversion both to high-repetition-rate and high-energy applications.
Hybrid control of robot manipulators (2005)

A robot manipulator must be able to satisfy any consistent position and force specifications in a well-defined Cartesian coordinate frame. In this paper, we present a method to achieve such a hybrid control of position and force. While the desired compliance is specified in Cartesian space, the control is accomplished in joint space, thus effectively reducing the computation load. Results show that accurate position and force control is obtained.
Model‐Based Analysis of Potassium Removal During Hemodialysis (2009)

Potassium ion (K(+)) kinetics in intra- and extracellular compartments during dialysis was studied by means of a double-pool computer model, which included potassium-dependent active transport (Na-K-ATPase pump) in 38 patients undergoing chronic hemodialysis. Each patient was treated for 2 weeks with a constant K(+) dialysate concentration (K(+)(CONST) therapy) and afterward for 2 weeks with a time-varying (profiled) K(+) dialysate concentration (K(+)(PROF) therapy). The two therapies induced different levels of K(+) plasma concentration (K(+)(CONST): 3.71 +/- 0.88 mmol/L vs. K(+)(PROF): 3.97 +/- 0.64 mmol/L, time-averaged values, P < 0.01). The computer model was tuned to accurately fit plasmatic K(+) measured in the course and 1 h after K(+)(CONST) and K(+)(PROF) therapies and was then used to simulate the kinetics of intra- and extracellular K(+). Model-based analysis showed that almost all the K(+) removal in the first 90 min of dialysis was derived from the extracellular compartment. The different K(+) time course in the dialysate and the consequently different Na-K pump activity resulted in a different sharing of removed potassium mass at the end of dialysis: 56% +/- 17% from the extracellular compartment in K(+)(PROF) versus 41% +/- 14% in K(+)(CONST). At the end of both therapies, the K(+) distribution was largely unbalanced, and, in the next 3 h, K(+) continued to flow in the extracellular space (about 24 mmol). After rebalancing, about 80% of the K(+) mass that was removed derived from the intracellular compartment. In conclusion, the Na-K pump plays a major role in K(+) apportionment between extracellular and intracellular compartments, and potassium dialysate concentration strongly influences pump activity.
An Adaptive Resolution Asynchronous ADC Architecture for Data Compression in Energy Constrained Sensing Applications (2010)

An adaptive resolution (AR) asynchronous analog-to-digital converter (ADC) architecture is presented. Data compression is achieved by the inherent signal dependent sampling rate of the asynchronous architecture. An AR algorithm automatically varies the ADC quantizer resolution based on the rate of change of the input. This overcomes the trade-off between dynamic range and input bandwidth typically seen in asynchronous ADCs. A prototype ADC fabricated in a 0.18 μm CMOS technology, and utilizing the subthreshold region of operation, achieves an equivalent maximum sampling rate of 50 kS/s, an SNDR of 43.2 dB, and consumes 25 μW from a 0.7 V supply. The ADC is also shown to provide data compression for accelerometer applications as a proof of concept demonstration.
A saccharide ‘sponge’. Synthesis and properties of a dendritic boronic acid (1996)

Very low concentrations of D-galactose and D-fructose are bound to a dendrimer containing eight boronic acids and eight anthracene units; the binding events are sensitively monitored by changes in the fluorescence intensity.
The Bentiromide Test for Pancreatic Exocrine Insufficiency (1984)

The bentiromide test, a test of pancreatic exocrine function, has recently been approved for clinical use by the Food and Drug Administration. The test has been studied in adult patients with chronic pancreatic disease and in children with cystic fibrosis. The 500-mg dose and 6-hour urine collection period appear optimal for separating patients with chronic pancreatic disease from control subjects. Side effects with the 500-mg dose are virtually nonexistent. This simply performed outpatient test of chymotrypsin function appears to be an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency.
The Design of a Multiple Cavity Equalizer (1982)

A simplified design method for a group delay equalizer with multiple poles has been developed, which replaces the conventional approach of cascading several C- and D-type equalizers by one equalizer with multiple poles. A prototype 4-pole equalizer has been designed and tested with satisfactory performance.