gebhart/patrepeval huggingface dataset:
Measurements of the Temperature Coefficient of Resonance Absorption in Uranium Metal and Uranium Oxide (1963)

The relative effective resonance integral of U238 has been measured as a function of temperature for uranium and UO2 cylinders, 0.986 and 0.973 cm diam, respectively. The Doppler coefficients α and β are defined by: RIo refers to the effective resonance integral (excluding 1/υ absorption) at 20°C, and to and To are 20°C and 293°K respectively.The measurements utilized the activation technique in which the induced Np239 activity of a uranium bearing specimen was determined as a function of specimen temperature during irradiation.Measured values for α and β corrected for thermal expansion, 1/υ absorption, fission activity and a deviation from a 1 /E epithermal flux are for metal α = 1.14 ± 0.07 × 10 -4/oC, β = 0.53 ± 0.03 × 10-2/(°K)1/2 and for oxide α = 1.34 ± 0.11 × 10-4/°C, β = 0.69 ± 0.06 × 10-2/ (°K)1/2. The temperature increments for which these values have been obtained were 580 and 950°C for uranium metal and oxide respectively.The results presented in this report are considered to be consistent with the results of other experiments in which the activation technique was used but are lower than theoretical predictions given by Nordheim and Rosén.
Observability Criteria for Bearings-Only Target Motion Analysis (1981)

The observability requirements for bearings-only target motion analysis (TMA) are rigorously established by solving a third-order nonlinear differential equation. Closed form expressions are developed and subsequently used to specify necessary and sufficient conditions on own-ship motion that insure a uniquetracking solution. It is shown that for certain types of maneuvers the estimation process remains unobservable, even when the associated bearing rate is nonzero. Such maneuvers are frequently overlooked in heuristic discussions of TMA observability, which may account for some common misconceptions regarding the characteristics of acceptable own-ship motion.
A Novel System for the Efficient Generation of Antibodies Following Immunization of Unique Knockout Mouse Strains (2010)

We examined a simple, fast, and highly efficient strategy to produce antibodies by mining two expanding databases: namely those of knock-out mice and 3D crystallographic protein-structure analysis. We conclude that the immunization of knock-out mice should be a strategy of choice for antibody production.
Application of the approaches Top-down and Bottom-up for the construction of a Risk Mapping of an insurance company (2014)

There are two main possible approaches for the construction of a risk mapping. The first one consists to identify the risks of the company, and the second is based on a census of risks by the Executive Committee. These two approaches are complementary. In the top-down approach, the major risks are identified by the members of the Executive Committee, with regard to the strategy followed by the insurance company. The Risks are then attached to the process of the activity. In the bottom-up approach, the census of the processes of the company establishes the starting point of the process. This article aims to present the outline of the two approaches, Top-Down and Bottom-Up, and apply them to risk management in insurance. The idea is to define a methodology to assess the risks associated with different processes, and rank them in order of priority in a risk mapping.
Effect of D-amino acids on structure and synthesis of peptidoglycan in Escherichia coli (1992)

Growth of Escherichia coli in the presence of certain D-amino acids, such as D-methionine, results in the incorporation of the D-amino acid into macromolecular peptidoglycan and can be lethal at high concentrations. Previous studies suggested that incorporation was independent of the normal biosynthetic pathway. An enzymatic reaction between the D-amino acid and macromolecular peptidoglycan was proposed as the mechanism of incorporation. The application of more advanced analytical techniques, notably high-pressure liquid chromatography, revealed that the presence of a D-amino acid susceptible to incorporation induced a multiplicity of alterations in peptidoglycan metabolism. Results derived basically from the study of samples treated with D-Met, D-Trp, and D-Phe indicated that the incorporation of a D-amino acid results in the accumulation of two major new muropeptides whose general structures most likely are GlucNAc-MurNAc-L-Ala-D-Glu-m-diaminopimelic acid-D-aa and GlucNAc-MurNAc-L-Ala-D-Glu-m-diaminopimelic acid-D-Ala-GlucNAc-MurNAc-L-Ala-D-Glu-m-diaminopimelic acid-D-aa, where D-aa represents a residue of the added D-amino acid. Resting cells are proficient in the incorporation of D-amino acids and can reach peptidoglycan modification levels comparable to those in growing cells. Under our conditions, D-amino acids had no apparent effect on growth or morphology but caused a severe inhibition of peptidoglycan synthesis and cross-linking, possibly leading to a reduction in the amount of peptidoglycan per cell. The properties of the reaction support the involvement of a penicillin-insensitive LD-transpeptidase enzyme in the synthesis of modified muropeptides and a possible inhibitory action of D-amino acids on high-molecular-weight penicillin-binding proteins.
Optimal Antibiotics for Treating Peritonsillar Abscess (2014)

We retrospectively examined the bacterial isolates, tolerance to antibiotics, and clinical course in 88 patients with peritonsillar abscess who were treated at the Matto Ishikawa Public Central Hospital between October 2007 and December 2012. Peritonsillar pus was collected by needle aspiration in 57 cases, and 90 strains of bacteria were detected and tested for drug sensitivity. In 16 cases (32%), only anaerobes were cultured. In 18 cases (35%), only aerobes were cultured. And in 16 cases (28%), both anaerobes and aerobes were cultured. In 3 cases (5%), neither anaerobes nor aerobes were detected. Overall, 6 of the 41 anaerobic strains (14.6%) and 8 of the 35 aerobic strains (22.9%) were resistant to clindamycin(CLDM). None of the 25 anaerobes were resistant to ampicillin/sulbactam (ABPC/SBT). The rate of resistance to ABPC/SBT among the aerobes was less than or equal to the rate of the resistance of aerobes to ABPC (9.8%). Against carbapenem (CBP), all 42 anaerobic strains did not have any tolerance, and only 2 of the 42 aerobes were resistant (4.8%). Judging from the above, ABPC/SBT might be suitable as a first-line antibiotic for the treatment of peritonsillar abscess, rather than CLDM, because of the low rate of drug resistance and the narrow spectrum. CBP should be regarded as a second-line treatment, since CBP abuse can induce tolerance.
Association of Body Mass Index With Adherence to Cervical Cancer Screening Recommendations in Hispanic Women (2019)

Adherence to cervical cancer screening in this population was below the Healthy People 2020 target of 93%, especially for women with morbid obesity. These findings highlight the importance of adequate interventions to decrease cervical cancer screening disparities in these women.
Structure and Biosynthesis of the BT Peptide Antibiotic from <i>Brevibacillus texasporus</i> (2005)

We isolated a novel gram-positive bacterium, Brevibacillus texasporus, that produces an antibiotic, BT. BT is a group of related peptides that are produced by B. texasporus cells in response to nutrient limitation. We report here purification and determination of the structure of the most abundant BT isomer, BT1583. Amino acid composition and tandem mass spectrometry experiments yielded a partial BT1583 structure. The presence of ornithine and d-form residues in the partial BT1583 structure indicated that the peptide is synthesized by a nonribosomal peptide synthetase (NRPS). The BT NRPS operon was rapidly and accurately identified by using a novel in silico NRPS operon hunting strategy that involved direct shotgun genomic sequencing rather than the unreliable cosmid library hybridization scheme. Sequence analysis of the BT NRPS operon indicated that it encodes a colinear modular NRPS with a strict correlation between the NRPS modules and the amino acid residues in the peptide. The colinear nature of the BT NRPS enabled us to utilize the genomic information to refine the BT1583 peptide sequence to Me(2)-4-methyl-4-[(E)-2-butenyl]-4,N-methyl-threonine-L-dO-I-V-V-dK-V-dL-K-dY-L-V-CH2OH. In addition, we report the discovery of novel NRPS codons (sets of the substrate specificity-conferring residues in NRPS modules) for valine, lysine, ornithine, and tyrosine.
Smectic Mesophase Properties of Dimeric Compounds. 2. Distinct Formation of Smectic Structures with Antiferroelectric Ordering and Frustration (2000)

Abstract We have prepared two series of dimeric compounds, which comprise the schiff's base mesogen, alkyl spacer with the carbon number of 5 and alkyl or alkoxy tail with the carbon number of m = 4∼16. In these compounds, we observed three types of smectic liquid crystals, the single layer phase with the tail group randomly mixing with the spacer, the bilayer phase in which the segregation of the spacer and tail groups takes place and so two mesogenic layers are included within a repeat unit, the frustrated smectic phase in which the density modulation appears along the layer as well as the layer normal. The bilayer phase was found to be antiferroelectric and the frustrated smectic phase was considered to result from the two dimensional escape from the dipolar interaction. The phase behaviour with m and the structure and properties of each phase will be described in detail.
Functional Chromatography Reveals Three Natural Products that Target the Same Protein with Distinct Mechanisms of Action (2014)

Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1-hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high-throughput or phenotypic screening platforms.
Specificity inversion of <i>Ochrobactrum anthropi</i> D‐aminopeptidase to a D,D‐carboxypeptidase with new penicillin binding activity by directed mutagenesis (2005)

The serine penicillin-recognizing proteins have been extensively studied. They show a wide range of substrate specificities accompanied by multidomain features. Their adaptation capacity has resulted in the emergence of pathogenic bacteria resistant to beta-lactam antibiotics. The most divergent enzymatic activities in this protein family are those of the Ochrobactrum anthropi D-aminopeptidase and of the Streptomyces R61 D,D-carboxypeptidase/transpeptidase. With the help of structural data, we have attempted to identify the factors responsible for this opposite specificity. A loop deletion mutant of the Ochrobactrum anthropi D-aminopeptidase lost its original activity in favor of a new penicillin-binding activity. D-aminopeptidase activity of the deletion mutant can be restored by complementation with another deletion mutant corresponding to the noncatalytic domain of the wild-type enzyme. By a second step site-directed mutagenesis, the specificity of the Ochrobactrum anthropi D-aminopeptidase was inverted to a D,D-carboxypeptidase specificity. These results imply a core enzyme with high diversity potential surrounded by specificity modulators. It is the first example of drastic specificity change in the serine penicillin-recognizing proteins. These results open new perspectives in the conception of new enzymes with nonnatural specificities. The structure/specificity relationship in the serine penicillin-recognizing proteins are discussed.
Optimising daytime deliveries when inducing labour using prostaglandin vaginal inserts (2015)

When optimising daytime deliveries, different times to initiate induction of labour may be appropriate depending on parity and the type of retrievable prostaglandin vaginal insert used.
Parameter-driven data path VHDL model generation for ASIC design (2002)

Previous methods for automatic generation of behavioral VHDL models require an ASIC engineer to have knowledge of particular input techniques such as graphical entry, specialized table, etc. The author presents a new method that takes the user-specified engineering parameters as inputs for the behavioral VHDL model generation. Since it is a common practice for the ASIC engineer to specify circuits using engineering parameters, this parameter-driven method allows an engineer to create a VHDL model quickly and easily. In addition, unlike the previous methods, the proposed method covers a wide range of circuits, including MSI circuits as well as FSM and CMB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DeepMeSH: deep semantic representation for improving large-scale MeSH indexing (2016)

Supplementary data are available at Bioinformatics online.
Hardware-Anchored Security Based on SRAM PUFs, Part 2 (2012)

Physical unclonable functions based on static RAM can help provide new approaches to such applications as secure key storage, secure boot for flash-memory-based embedded devices without on-chip nonvolatile memory, hardware-software binding, and generating true random numbers. Part 1 is available at http://doi.ieeecomputersociety.org/10.1109/MSP.2012.68.
Integral Imaging Monitors with an Enlarged Viewing Angle (2015)

Enlarging the horizontal viewing angle is an important feature of integral imaging monitors. Thus far, the horizontal viewing angle has been enlarged in different ways, such as by changing the size of the elemental images or by tilting the lens array in the capture and reconstruction stages. However, these methods are limited by the microlenses used in the capture stage and by the fact that the images obtained cannot be easily projected into different displays. In this study, we upgrade our previously reported method, called SPOC 2.0. In particular, our new approach, which can be called SPOC 2.1, enlarges the viewing angle by increasing the density of the elemental images in the horizontal direction and by an appropriate application of our transformation and reshape algorithm. To illustrate our approach, we have calculated some high-viewing angle elemental images and displayed them on an integral imaging monitor.
Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex (2002)

SUMOs are small ubiquitin-related polypeptides that are reversibly conjugated to many nuclear proteins. Although the number of identified substrates has grown rapidly, relatively little is still understood about when, where, and why most proteins are modified by SUMO. Here, we demonstrate that enzymes involved in the SUMO modification and demodification of proteins are components of the nuclear pore complex (NPC). We show that SENP2, a SUMO protease that is able to demodify both SUMO-1 and SUMO-2 or SUMO-3 protein conjugates, localizes to the nucleoplasmic face of the NPC. The unique amino-terminal domain of SENP2 interacts with the FG repeat domain of Nup153, indicating that SENP2 associates with the nucleoplasmic basket of the NPC. We also investigated the localization of the SUMO conjugating enzyme, Ubc9. Using immunogold labeling of isolated nuclear envelopes, we found that Ubc9 localizes to both the cytoplasmic and the nucleoplasmic filaments of the NPC. In vitro binding studies revealed that Ubc9 and SUMO-1-modified RanGAP1 bind synergistically to form a trimeric complex with a component of the cytoplasmic filaments of the NPC, Nup358. Our results indicate that both SUMO modification and demodification of proteins may occur at the NPC and suggest a connection between the SUMO modification pathway and nucleocytoplasmic transport.
A Comparison of the Use of Phenolase and Peroxidase for the Synthesis of Model Humic Acid‐type Polymers (1980)

Abstract Yields of HA (humic acid) and FA (fulvic acid) fractions of mushroom phenolase‐catalyzed humic acid‐type polymers varied considerably. The higher yields from 4 g of phenol mixture alone or with 1 g of various amino acids, glucosamine, or protein; and with 150 to 300 mg of phenolase varied from 1.5 to 2.5 g with about equal amounts in both fractions. As determined by use of 14 C‐labeled compounds, about 33% of the ferulic acid; 55% of catechol; 5 to 14% of glycine, lysine, and glucosamine; 50% of cysteine; and 100% of the protein present in the reaction mixtures were recovered in the ploymers. Using an adaptation of the peroxidase — H 2 O 2 method for preparing model lignins the yields of humic polymers were more consistent, varied from 2.5 to 3.5 g, and about 80% of each polymer was recovered as HA. Also about 77% of the ferulic acid; 95% of catechol; 23 to 34% of glycine, lysine, and glucosamine; 63% of cysteine; and essentially all of the protein present in the reaction mixtures were recovered in the polymers. All model polymers were resistant to biodegradation in the soil. During 12 weeks 4 to 8% of benzene ring carbons and 8 to 25% of ferulic acid side group, amino acid, glucosamine, and protein carbons were evolved as CO 2 .
INVESTIGATION OF A MULTIPLE BEAM SCANNING CIRCULAR ARRAY, (1962)

One phase of a theoretical and experimental pro gram directed toward the development of a multi ple-beam or steerable cylindrical array is de scribed. The object was to develop a cylindrical array which could provide high resolution cover age over 360 degrees of azimuth angle. The basic intent of the program was to theoretically ana lyze, and experimentally verify, an RSi con ceived technique for reducing the problem of processing the antenna elements of cylindrical arrays to one analogous to the element processing of linear arrays. This equating of the array processes allows all of the techniques developed for linear arrays to be applied to cylindrical arrays. A partial listing of these processing techniques would include the synthesis of any desired far-field radiation patterns, the scanning of the synthesized patterns, or the multiple beaming of these synthesized patterns. Hence, the cylindrical array may be used to provide steerable or multiple beams over 360 degrees in a horizon plane by employing the same scanning and multiple-beam processing developed for linear arrays. The distinction, of course, is that linear arrays, at the extreme, are limited to less than 120 degrees of coverage. (Author)
Differential natural killer cell–mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes (2007)

Decline of peak viremia during acute HIV-1 infection occurs before the development of vigorous adaptive immunity, and the level of decline correlates inversely with the rate of AIDS progression, implicating a potential role for the innate immune response in determining disease outcome. The combined expression of an activating natural killer (NK) cell receptor, the killer immunoglobulin-like receptor (KIR) 3DS1, and its presumed ligand, human leukocyte antigen (HLA)-B Bw4-80I, has been associated in epidemiological studies with a slow progression to AIDS. We examined the functional ability of NK cells to differentially control HIV-1 replication in vitro based on their KIR and HLA types. NK cells expressing KIR3DS1 showed strong, significant dose- and cell contact-dependent inhibition of HIV-1 replication in target cells expressing HLA-B Bw4-80I compared with NK cells that did not express KIR3DS1. Furthermore, KIR3DS1+ NK cells and NKLs were preferentially activated, and lysed HIV-1 infected target cells in an HLA-B Bw4-80I-dependent manner. These data provide the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication.
Introduction (1985)

The basic assumptions underlying this book are, that man is an animal needing by nature to have a purpose or purposes in view, and that what he takes as his ultimate purpose has an intimate relationship with what he does and becomes, that is, with his nature as a whole. The first assumption is subject to empirical challenge, though the room for doubt seems small: people who can envisage no short-term or long-term purpose are more often found inside psychiatric hospitals than outside. But the second assumption is contentious, and one of my aims here is to throw some light on it by examining at length four relevant works of fiction. The fictions selected all explore profoundly questions concerning human purposes and what happens to men who give various answers to those questions. But different forms of fiction have interestingly different ways of relating human purposes to various obstructions, external and internal — the recalcitrance of the brute world to human will, and the confusion of purpose with fantasy. So what is also involved is a discussion of how fictional form can embody, shape, refine conceptions of human purpose, which I hope will provide some insight into certain general aspects of fictional technique.
The Reactions of Perfluoronitriles with Grignard Reagents<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reactions of Perfluoronitriles with Grignard Reagents1E. T. McBee, O. R. Pierce, and D. D. MeyerCite this: J. Am. Chem. Soc. 1955, 77, 4, 917–919Publication Date (Print):February 1, 1955Publication History Published online1 May 2002Published inissue 1 February 1955https://pubs.acs.org/doi/10.1021/ja01609a035https://doi.org/10.1021/ja01609a035research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts