gebhart/patrepeval huggingface dataset:
Design of a database and cache management strategy for a global information infrastructure (2002)

NTT Software Labs. is producing a distributed, self-configuring information navigation infrastructure designed to scale to global proportions. For reasons of large scale, unreliability (of the Internet, its connected computers, and the implementations), and the complete autonomy of the participants, a number of difficult database and cache consistency problems arise that are not solved by techniques commonly used either for the Internet (i.e. DNS), or for existing distributed database systems. This paper describes a set of strategies designed to solve these problems. In particular, it focuses on the use of third-party detection and notification of database and cache inconsistency.
Fractalkine mediates natural killer-dependent antitumor responses in vivo. (2003)

CX3CR1 has been described previously as a marker of human cytotoxic effector cells. We evaluated the possibility of using its ligand, CX3CL1, to redirect immune response against tumors. When murine lymphoma cell lines (EL4 and its derivative EG7) stably transfected with human-CX3CL1 were injected s.c. into C57BL/6 mice, the tumor growth was severely impaired when compared with the growth of control cell lines. This antitumor effect of CX3CL1 was also found in T- and B-cell-deficient Rag1-/- mice but vanished in natural killer (NK) cell-deficient beige mice and in CX3CR1-/- mice, suggesting the involvement of CX3CR1-expressing NK cells. In addition, increased NK cell infiltration was observed in CX3CL1-producing tumors compared with controls. The effect of CX3CR1 on tumor growth required host cytotoxic effector cell functions because both IFNgamma-/- and perforin-/- mice were resistant to CX3CL1 antitumor effect. Finally, intratumoral injection of DNA plasmid coding for a chimeric immunoglobulin presenting the CX3CL1 chemokine domain provided strong antitumor activity. Together, these data demonstrate that the CX3CL1 can reduce incidence and size of lymphoma in vivo through increased recruitment of activated NK cytotoxic cells. These findings offer the first evidence of the potential of chimeric immunoglobulin-chemokines in anticancer therapy.
Differential Processing of Propeptide Inhibitors of Rap Phosphatases in <i>Bacillus subtilis</i> (2000)

In the phosphorelay signal transduction system for sporulation initiation in Bacillus subtilis, the opposing activities of histidine kinases and aspartyl phosphate phosphatases determine the cell's decision whether to continue with vegetative growth or to initiate the differentiation process. Regulated dephosphorylation of the Spo0A and Spo0F response regulators allows a variety of negative signals from physiological processes that are antithetical to sporulation to impact on the activation level of the phosphorelay. Spo0F approximately P is the known target of two related phosphatases, RapA and RapB. In addition to RapA and RapB, a third member of the Rap family of phosphatases, RapE, specifically dephosphorylated the Spo0F approximately P intermediate in response to competence development. RapE phosphatase activity was found to be controlled by a pentapeptide (SRNVT) generated from within the carboxy-terminal domain of the phrE gene product. A synthetic PhrE pentapeptide could (i) complement the sporulation deficiency caused by deregulated RapE activity of a phrE mutant and (ii) inhibit RapE-dependent dephosphorylation of Spo0F approximately P in in vitro experiments. The PhrE pentapeptide did not inhibit the phosphatase activity of RapA and RapB. These results confirm previous conclusions that the specificity for recognition of the target phosphatase is contained within the amino acid sequence of the pentapeptide inhibitor.
Seeing double (2008)

In 1971, Intel astounded the world with its 4004 microprocessor, whose 2300 transistors could execute 60 000 instructions per second. Today, the 820 million transistors of an Intel Core 2 Extreme chip can process nearly 72 billion instructions per second.
Arterial System in Agamidae with Special Reference to the System in Agama tuberculata Gray (Reptilia: Lacertilia) (1974)

The arterial system in Agama tuberculata Gray with perhaps several primitive features is similar essentially to the system in Agama agama and like Uromastix and Calotes shows a number of similarities with the system in Sphenodon. While the posterior tracheal artery as a branch of the pulmonary artery seems to be peculiar to the agamid lizards, the mode of origin and distribution of the visceral arteries seem to be extremely variable within the family. On comparing the blood supply to the liver and duodenum in Agama, Uromastix and Calotes, 3 pathways may obtain within these members, each characteristic of each genus.
IL‐18 is produced by prostate cancer cells and secreted in response to interferons (2003)

Murine models have shown that IL-18 has antiangiogenic and antitumor effects, but little is known about IL-18 production in human tumors. We investigated IL-18 expression in clinically localized prostate cancers by immunohistochemistry and showed that 75% of the prostate cancers studied (27/36 cases) presented with tumor cells producing IL-18. Prostate tumor cell lines PC-3, DU 145 and LNCaP synthesized the immature form of IL-18 (p24). IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO). Interestingly, IFN-alpha also induced IL-18 secretion of the poorly differentiated cell line PC-3. PC-3 and DU 145, but not the well-differentiated cell line LNCaP, expressed IL-18R alpha (IL-1Rrp) protein and transcripts for IL-18R beta (AcPL). Exogenous IL-18 increased mitochondrial activity of both cell lines evaluated by the tetrazolium (MTT) assay but did not influence their proliferation. This indicated that prostate tumor cells could secrete IL-18 in response to IFN-gamma in the tumor microenvironment and that IL-18 could act as a autocrine/paracrine factor for the tumor. In the cohort of patients studied, IL-18 expression in prostate cancers (with up to 10% of tumor cells stained) was associated with a favorable outcome and equally predictive as pathologic stage on multivariate analysis (log rank test, p = 0.02). Tumor IL-18 production is a novel physiopathologic feature of prostate cancer and appears to be a favorable event in the course of the disease. Modulation of IL-18 production by interferons could have a beneficial clinical effect, which deserves further investigation.
Quantitative measurement of the moisture content in thin films (2002)

A description is given of the modification and application of a moisture evolution analyzer to quantitatively measure the moisture content of thin-film dielectrics used in VLSI manufacture. The development of computerized acquisition of moisture, temperature, and time data permits adsorbed water to be distinguished from more tightly bound absorbed water. The incorporation of a computer-driven temperature controller and a 7-in.-diameter crucible furnace allows the moisture evolution characteristics of thin films on 150-mm-diameter wafers to be studied under a wide variety of temperature cycles and ramps up to 1000 degrees C. Studies of thermal oxides, plasma oxides, spin-on-glass, and CVD doped and undoped oxides show moisture contents from less than 0.01 wt.% to in excess of 10 wt.% water, demonstrating the sensitivity and range of the technique. The results for borophosphosilicate glass (BPSG) thin films as a function of doping levels are presented. The moisture in these films was found to be partitioned approximately equally between adsorbed and absorbed moisture. As the doping levels (wt.%B/wt.%P) were varied from 0/4.2 to 2.5/3.8, the moisture content varied by 30%. The effects of low-temperature heat treatments and alternative deposition chemistries are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Forbush decrease of March 2012 detected using a commercially-available muon-tomography cargo scanner (2012)

Muon-tomography (MT) scanners are built and operated to detect the smuggling of contraband in cargo. Simultaneously with cargo scanning, MT systems can be used to measure naturally occurring changes in cosmic radiation. Our commercially-available MT system detected the decrease in muon flux following the 6 March 2012 coronal mass ejection. We discuss the practical implications for cargo scanning posed by variation in background cosmic radiation.
Controlled Velocity Testing of an 8-kW Wind Turbine (2001)

This paper describes a case study of the controlled-velocity test of an 8-kW wind turbine. The turbine was developed in response to the U.S. Department of Energy's small wind turbine program. As background, the prototype development is discussed. The turbine mechanical and electrical components are described. The turbine was tested on a flatbed truck and driven down an airfield runway at constant relative wind speed. Horizontal furling was used to control over-speed. Various parameters were changed to determine their effects on furling. The testing showed that the machine had insufficient rotor offset for adequate furling. Also, a rotor resonance problem was discovered and remedied. Problems associated with taking the measurements made it difficult to determine if the truck test was a suitable method for code validation. However, qualitative observations gleaned from the testing justified the effort.
Pathobiology of Lp(a) in calcific aortic valve disease (2017)

Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder. Gene variant in the LPA gene, which encodes for apolipoprotein(a), has been associated at the genome-wide level with CAVD. The process whereby Lp(a) promotes the development of CAVD is under intensive investigation and recent data have shed important insights into disease biology. In this regard, autotaxin (ATX), a lysophospholipase D, interacts with Lp(a) and promotes the mineralization of the aortic valve. Areas covered: In this paper, we are reviewing the biology of Lp(a) and the latest discoveries about the molecular processes that link this lipoprotein with the development of CAVD including the role of ATX. Expert commentary: Elevated Lp(a) levels are genetically determined and considered as an important risk factor for CAVD. Understanding how Lp(a) promotes the development/progression of CAVD is crucial as it may hold promise for the development of new therapies.
Polythiourethane microcapsules as novel self-healing systems for epoxy coatings (2017)

A novel group of microcapsule-based self-healing systems for epoxy coatings was developed. Microcapsules with polythiourethane shell wall were synthesized via interfacial polymerization from selected diisocyanates and thiols and dispersed in epoxy matrix. The obtained composites were tested for their self-healing efficiency using three-point bending test (TPBT) and scratch test. Two sets of each composite samples as well as reference (neat diglycidyl ether of bisphenol A epoxy with polyamine adduct hardener) were tested with TPBT using two methods. Standard method according to ISO 178 was applied for the first set and custom method with pre-bending with 20 N force and standard TPBT after 24 h of self-healing—for the second set. Pre-bending was applied to obtain microcracks (without sample cracking) for internal self-healing process occurrence. Scratch test allowed to evaluate self-healing efficiency at composite surface and chemical resistance of samples. FT-IR spectroscopy was conducted to confirm occurrence of self-healing process based on polyurethane secondary network forming.
Membrane interactions of designed cationic antimicrobial peptides: The two thresholds (2008)

Novel cationic antimicrobial peptides (CAPs) designed in our lab-typified by sequences such as KKKKKKAAX-AAXAAXAA-NH(2), where X = Phe/Trp-display high antibacterial activity but exhibit little or no hemolytic activity towards human red blood cells even at high doses. To clarify the mechanism of their selectivity for bacterial versus mammalian membranes and to increase our understanding of the relationships between primary sequence and bioactivity, a library of derivatives was prepared by increasing segmental hydrophobicity, in which systematic substitutions of Ala for two, three, or four Leu residues were made. Conformationally constrained dimeric and cyclic derivatives were also synthesized. The peptides were examined for activity against pathogenic bacteria (Pseudomonas aeruginosa), hemolytic activity on human red blood cells, and insertion into models of natural bacterial membranes (containing anionic lipids) and mammalian membranes (containing zwitterionic lipids + cholesterol). Results were compared with corresponding properties of the natural CAPs magainin and cecropin. Using circular dichroism and fluorescence spectroscopy, we found that peptide conformation and membrane insertion were sequence dependent, both upon the number of Leu residues, and upon their positions along the hydrophobic core. Membrane disruption was likely enhanced by the fact that the peptides contain potent dimerization-promoting sequence motifs, as assessed by SDS-PAGE gel analysis. The overall results led us to identify distinctions in the mechanism of actions of these CAPs for disruption of bacterial versus mammalian membranes, the latter dependent on surpassing a "second hydrophobicity threshold" for insertion into zwitterionic membranes.
Design and implementation of CIC based decimation filter for improved frequency response (2009)

The over sampled output of a sigma delta modulator is decimated to Nyquist sampling rate by Decimation filters. The decimation filters work two fold, they decimate the sampling rate by a factor of OSR [over sampling rate] in doing so they remove the outband quantization noise resulting in an increase in resolution. The speed, area and power consumption of oversampled converter are governed largely by decimation filters in sigma-delta A/D converters. The paper presents a design and implementation of a sigma-delta digital decimation filter. The decimation filter structure is based on cascaded-integrated Comb (CIC) filter. A second decimation filter using CIC for large rate change and cascaded FIR filters, for small rate changes, to improve the frequency response. The proposed structure is even more hardware efficient.
A Study of Seismic Resistant Design for Base-Isolated Bridges(I) (1997)

The base isolation technique and its benefits in reducing the transmitted earthquake energy into a structure have gained increasing recognition during the last two decades. Unfortunately, the current available design procedures, especially for base-isolated bridges, seem inadequate and too restrictive. As a result, practical design procedure still relies upon a series of deterministic time history analyses. In this study, the evaluation of the possibility of the normal mode method to predict the nonlinear seismic responses of base isolated bridges has been performed. The applicability has been examined through the numerical approach with isolator's elastic or plastic states of the base isolated bridges. Numerical results show that the 1st. mode period and the various responses are varied with the state but are conversed. And, the result show that the normal mode method is applicable to predict the seismic responses and to design the babe isolated bridge. Various analysis method to bridges with bilinearized hysteresis isolator and various pier heights are evalulated.
Novel topology for parallel connection of soft switching, high power, high frequency inverters (2002)

Inductive heating applications like pipe welding or steel strip annealing require electrical power ratings of several MWs at frequencies up to 100 kHz and higher. The large power-frequency product represents a significant challenge for today's semiconductor technology. As the absolute maximum rating of a single stage inverter is often far below rated power, several inverters or several devices have to be connected in parallel. This paper presents a novel topology, consisting of parallel connected soft-switching high-frequency inverters. Distinctive features include flexible configurations, negligible shunt currents between inverters, and equally shared power among inverters. Furthermore, compared to a single-inverter-system, no additional reactive components are necessary for connecting inverters in parallel and there is no need of a high frequency transformer to adapt the impedance of the load to the inverters.
Trends in Cochlear Implants (2004)

More than 60,000 people worldwide use cochlear implants as a means to restore functional hearing. Although individual performance variability is still high, an average implant user can talk on the phone in a quiet environment. Cochlear-implant research has also matured as a field, as evidenced by the exponential growth in both the patient population and scientific publication. The present report examines current issues related to audiologic, clinical, engineering, anatomic, and physiologic aspects of cochlear implants, focusing on their psychophysical, speech, music, and cognitive performance. This report also forecasts clinical and research trends related to presurgical evaluation, fitting protocols, signal processing, and postsurgical rehabilitation in cochlear implants. Finally, a future landscape in amplification is presented that requires a unique, yet complementary, contribution from hearing aids, middle ear implants, and cochlear implants to achieve a total solution to the entire spectrum of hearing loss treatment and management.
Reaction of nitriles with phosgene. IV. Facile one-step synthesis of isoquinoline nucleus (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of nitriles with phosgene. IV. Facile one-step synthesis of isoquinoline nucleusShozo Yanagida, Masataka Ohoka, and Saburo KomoriCite this: J. Org. Chem. 1969, 34, 12, 4127–4130Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://pubs.acs.org/doi/10.1021/jo01264a080https://doi.org/10.1021/jo01264a080research-articleACS PublicationsRequest reuse permissionsArticle Views261Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection and Recovery of Coverage Holes in Wireless Sensor Networks (2013)

Wireless Sensor Networks (WSN) consists of distributed low-cost sensing nodes with autonomous network. Several anomalies can occur in wireless sensor networks that may form various coverage holes. These holes may disturb the existing coverage or connectivity, and impair desired functionalities of networks. Hence, it is essential to detect and recovery coverage holes in order to ensure the full operability of a WSN. In the paper, we propose a decentralized, coordinate-free, node-based coverage hole detection algorithm. It is based on boundary critical points, and can be run on a single node with verifying boundary critical points from neighbors. The hole patching algorithm is implemented with the concept of perpendicular bisector and our detection algorithm. The patching sensor nodes are deployed on hole boundary bisectors. Simulation demonstrates that our algorithm can detect and recover coverage hole, and guarantee full coverage in hostile environments with an effective manner.
Motion Tracking Applied in Assembly for Worker Training in different Locations (2016)

In cooperation between a German and a Vietnamese manufacturing laboratory, activities of training for assembly are performed by support of motion tracking at similar workplaces. The assembly of bicycle e-hubs is trained with Vietnamese students to check the transfer of assembly process knowledge between distant countries. The experimental set-up consists of the remote “teach-in” of assembly instructions, motion tracking on workplaces and the evaluation of student's performance. The applicability of motion tracking vs. traditional paper based instructions for initial learning is investigated.
Slavery: The Progressive Institution? (1974)

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A framework for mobile healthcare applications over heterogeneous networks (2011)

Future healthcare applications will require operation over heterogeneous networks due to mobility of patient, caregiver and provisioning of healthcare services anytime anywhere. In contrast with applications using protocols for specific networking technologies, we propose to include a unified middleware to isolate applications from mobility management, client discovery and transport of multimedia traffic. We propose an all IP-based framework based on SIP protocol for the unified middleware. The architecture is described. We describe how handovers over heterogeneous networks could be implemented in this architecture which provide better QoS and low packet loss during transitions. A laboratory prototype to demonstrate the above concepts is presented.
Solubility of Hydrogen in PdAg and PdAu Binary Alloys Using Density Functional Theory (2006)

The present work deals with the study of palladium-silver (PdAg) and palladium-gold (PdAu) binary alloys over a broad range of temperatures and alloy compositions using density functional theory (DFT) to find possible conditions where the solubility of hydrogen (H) is significantly higher than that of pure palladium (Pd). Several alloy structures, such as Pd(100-x)Ag(x) with x = 14.81, 25.93, 37.04, and 48.51, Pd(100-x)Aux with x = 14.81, 25.93, and 37.04, and Pd(100-x)Cu(x) with x = 25.93 and 48.51 were considered. The lattice constants of these structures were optimized using DFT, and relaxed structures were used for the estimation of binding energy. It was found that the solubility of H in PdAg is higher than pure Pd with a maximum at approximately 30% Ag at 456 K. Also, the solubility of PdAu alloys was higher than pure Pd with a maximum at about 20% Au with a solubility 12 times higher than that of pure Pd. It was found that for a 3.7% H concentration in a PdAg alloy, a cell expansion of 0.15-0.2% occurs, which if ignored may affect the individual binding energy of the O-site by approximately 3.56% and may affect the predicted solubility by approximately 11.8%.