gebhart/patrepeval huggingface dataset:
Binding of ATP-Sensitive Potassium Channel (K<sub>ATP</sub>) Openers to Cardiac Membranes:  Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing Potencies (1998)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTBinding of ATP-Sensitive Potassium Channel (KATP) Openers to Cardiac Membranes: Correlation of Binding Affinities with Cardioprotective and Smooth Muscle Relaxing PotenciesKarnail S. Atwal, Gary J. Grover, Nicholas J. Lodge, Diane E. Normandin, Sarah C. Traeger, Paul G. Sleph, Robert B. Cohen, Catherine C. Bryson, and Keneth E. J. DickinsonView Author Information Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543-4000 Cite this: J. Med. Chem. 1998, 41, 3, 271–275Publication Date (Web):January 13, 1998Publication History Received10 November 1997Published online13 January 1998Published inissue 1 January 1998https://pubs.acs.org/doi/10.1021/jm970762dhttps://doi.org/10.1021/jm970762drapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views198Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anatomy,Membranes,Potassium,Rodent models,Screening assays Get e-Alerts
Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision (2009)

Palladia has biological activity against canine MCTs and can be administered on a continuous schedule without need for routine planned treatment breaks. This clinical trial further shows that spontaneous tumors in dogs are good models to evaluate therapeutic index of targeted therapeutics in a clinical setting.
BayMeth: improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach (2014)

Affinity capture of DNA methylation combined with high-throughput sequencing strikes a good balance between the high cost of whole genome bisulfite sequencing and the low coverage of methylation arrays. We present BayMeth, an empirical Bayes approach that uses a fully methylated control sample to transform observed read counts into regional methylation levels. In our model, inefficient capture can readily be distinguished from low methylation levels. BayMeth improves on existing methods, allows explicit modeling of copy number variation, and offers computationally efficient analytical mean and variance estimators. BayMeth is available in the Repitools Bioconductor package.
Theory of Stable Formation of Ionic Vacancy in a Liquid Solution (2008)

The stable formation of ionic vacancy in a liquid solution was theoretically examined by means of a mean-field approximation based on Debye-Hückel’s framework. As the process of the vacancy formation, metal deposition from electrolyte solution was adopted, where anions associated with metallic ions adsorbed at electrical double layer were transcribed to the inner wall of the vacancy during the reaction. Then, it was concluded that since the formation energy of the vacancy is cancelled out by the electric work between the charged inner wall and its ionic atmosphere, the vacancy is stably self-organized. In copper deposition from potassium chloride solution and sulfuric acid solution, by measuring the partial molar volumes of the vacancies with gravity electrode, the radius of the vacancy theoretically predicted was experimentally validated.
Validation of advisory models for the prediction of voluntary intake of grass silage by lambs and dairy cows (1995)

Inaccurate prediction of silage intake is a major source of error in ration calculation. New routine methods such as electrometric titration (ET) and near infra-red reflectance spectroscopy (NIRS) have the potential to improve silage intake prediction (Offer et al., 1994). Development of new advisory models is slow because of the need to do large numbers of intake measurements. It is also essential that models are blind-tested (validated) on data not used for calibration. At SAC, sufficient animal intake data is now available for both calibration and validation although it is intended to continue to accumulate data for these purposes.
Introduction to the Proceedings of the Third International Congress of Corneal Cross-Linking (2008)

<p>For the past 3 years, the founders of riboflavin/ultraviolet A (UVA) cross-linking in the treatment of keratoconus, Theo Seiler, Eberhard Spoerl, and others, have hosted the International Congress of Corneal Cross-Linking during the month of December in Zurich, Switzerland. The last Congress, on December 7, 2007, was no different than the others in its diverse content and excellent presentations, except for the fact that this is the first year we have solicited a number of the best presentations to be compiled for inclusion in these Proceedings. Also, during this particular Congress, we voted as a group regarding the appropriate abbreviation to be used in reference to corneal cross-linking or collagen cross-linking. We selected “CXL” rather than CCL, CCC, C3R, etc, as the most appropriate abbreviation, and also selected “SXL” to represent scleral cross-linking.</p>
Channel-optimized video coding for low-power wireless applications (2002)

This paper presents an error-robust channel-optimized coding algorithm for the transmission of low-rate video over wireless channels. The proposed coder uses a robust channel-optimized trellis-coded quantization (COTCQ) stage that is designed to optimize the image coding based on the channel characteristics. The resilience to channel errors is obtained without the use of channel coding or error concealment techniques. Additionally, a novel adaptive classification scheme is employed, which eliminates the need for motion compensation. The robust nature of the coder eliminates the appearance of impulsive channel-error-induced artifacts in the decoded video, while increasing the security level of the encoded bit stream. Consequently, the proposed channel-optimized video coder is especially suitable for low-power wireless applications due to its reduced complexity, its robustness to nonstationary signals and channels, and its increased security level. Simulation results show that our coder provides outstanding quantitative and subjective coding performance for a wide variety of channel conditions.
Broadband applications and services of public switched networks (1989)

The results of work done at AT&T Bell Lab. on broadband data and video applications that may be used over a public switched network like that of a telephone company are summarized. Data and video applications and network services associated with these applications are discussed. While data applications are initially seen as being provided to business, video applications are expected to be aimed at residential users. These applications are presented in separate sections. The author describes example applications for broadband data services that could be offered to business within the next five years, namely: distributed computing; data distribution; electronic mail; and data retrieval. The following video applications are also described: video telephony; video teleconferencing; two-way enhanced video services; one way video/image distribution; video/image database retrieval; and video electronic mail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Risk Analysis Approach: From Subsurface to Surface (2005)

Abstract The quantitative assessment of the risk associated with the economic exploitation of a hydrocarbon field is mandatory to support, in an efficient and comprehensive way, the decision process guiding the development management system of an oil company. The Full Range Risk Analysis (FRRA) approach developed in Eni E&P Division allows the identification of uncertainties arising from each step of an integrated reservoir study, and the evaluation of their impact on recoverable reserves and on the economic value of a project. This methodology has already been successfully applied in the concept selection and concept definition phases of field development projects. Recently it has been further improved to be employed both in the evaluation stage, of a new discovery, and in the revamping of mature fields with production history. Introduction The Full Range Risk Analysis is aimed at investigating the whole range of possible reservoir development combinations. Its main objectives are:the support of the sanction of an economic discovery, considering an acceptable and accepted risk; the estimation of the value of information (VOI) of new data acquirement and the comparison between different appraisal strategies; the choice of the best development plan taking into account the main impacting reservoir uncertainties (mainly during concept selection phase);the quantification of downside/upside potential of the reservoir and of residual risk associated to field with production history. The presented workflow is a valuable tool in assessing the risk associated to a particular development scenario taking into account the entire surface and sub-surface uncertainties and therefore a methodology to support decisions in development projects. The FRRA methodology is fully based on Montecarlo approach and massive simulations of 3D reservoir models. Full Range Risk Analysis Workflow The current paper describes in detail the standard FRRA workflow along with the latest developments of the methodology, starting from the uncertainty definition phase up to the frequency distribution of the target variable, i.e. ultimate recovery, plateau length, NPV.
Evidence For Relaxin in Corpora Lutea of Late Pregnant Cows* (1980)

Relaxin was isolated from corpora lutea of third trimester pregnant cows. Fractions having relaxin activity eluted in the 6000 and 1400 molecular weight ranges when chromatographed on Bio-Gel P-10. Both fractions were shown to inhibit spontaneous contractions of the mouse uterus, and the 6000 molecular weight fraction promoted formation of the mouse interpubic ligament. Agar diffusion studies with an antiserum to purified porcine relaxin showed a continuous precipitin line with no spurring between the two bovine relaxin fractions and NIHR-P1 porcine relaxin standard. Electrofocusing of the 6000 molecular weight fraction demonstrated three fractions which were capable of inhibiting contractions of the mouse uterus and which cross-reacted with porcine relaxin antiserum. The isoelectric points of these three fractions were 8.8, 10.1, and 11.5. Large luteal cells in corpora lutea from cows in the midtrimester of pregnancy were detected that gave a positive stain for relaxin with the immunoperoxidase method.
Analogues of diverse structure are unable to differentiate native melatonin receptors in the chicken retina, sheep pars tuberalis and <i>Xenopus</i> melanophores (1996)

1. The pineal hormone melatonin exerts its biological effects through specific, high affinity G-protein coupled receptors. Recently, three melatonin receptor subtypes (Mel1a, Mel1b and Mel1c) have been cloned. Neither the cloned subtypes, nor the native receptors have yet been compared in a detailed pharmacological analysis. 2. The present study examined the structure-activity relationships of a series of 21 melatonin analogues, by comparing their potency on the pigment aggregation response in Xenopus laevis melanophores with their affinity in radioligand binding competition studies in chicken retina and sheep pars tuberalis (PT), two tissues in which melatonin is known to mediate a biological response. 3. All but four of the analogues were full melatonin receptor agonists producing a concentration-related redistribution of pigment granules in cultured Xenopus melanophores. The remaining analogues produced little pigment aggregation at 10 microM. 4. Saturation studies with 2-[125I]-iodomelatonin identified a single binding site in the chicken retina and sheep PT membranes, with a KD of 36.6 +/- 2.8 and 37.3 +/- 4.3 pM, and a maximal number of binding sites (Bmax) of 16.6 +/- 0.5, and 40.1 +/- 1.7 fmol mg-1 protein, respectively. 5. Comparison of the potency/affinity of the analogues for the binding sites gave a highly significant correlation in each case, retina/melanophore, r = 0.97 (P < 0.001, n = 17), PT/melanophore, r = 0.97 (P < 0.001, n = 17) and PT/retina, r = 0.98 (P < 0.001, n = 21). 6. Despite their large range in affinity and structural diversity these melatonin agonists were unable to distinguish between melatonin receptors in the chicken retina, sheep pars tuberalis and Xenopus melanophores.
Chitosan-adjuvanted Salmonella subunit nanoparticle vaccine for poultry delivered through drinking water and feed (2020)

Poor induction of mucosal immunity in the intestines by current Salmonella vaccines is a challenge to the poultry industry. We prepared and tested an oral deliverable Salmonella subunit vaccine containing immunogenic outer membrane proteins (OMPs) and flagellin (F) protein loaded and F-protein surface coated chitosan nanoparticles (CS NPs) (OMPs-F-CS NPs). The OMPs-F-CS NPs had mean particle size distribution of 514 nm, high positive charge and spherical in shape. In vitro and in vivo studies revealed the F-protein surface coated CS NPs were specifically targeted to chicken immune cells. The OMPs-F-CS NPs treatment of chicken immune cells upregulated TLRs, and Th1 and Th2 cytokines mRNA expression. Oral delivery of OMPs-F-CS NPs in birds enhanced the specific systemic IgY and mucosal IgA antibodies responses as well as reduced the challenge Salmonella load in the intestines. Thus, user friendly oral deliverable chitosan-based Salmonella vaccine for poultry is a viable alternative to current vaccines.
Leg extension power and muscle fiber composition. (1979)

The purpose of this investigation was to relate muscle fiber composition to the isokinetic measure of peak torque production through a range of leg extension velocities. Twenty-one males were biopsied from the vastus lateralis muscle to determine their percent distribution of slow twitch (%ST) and fast twitch (%FT) muscle fibers as identified through myofibrillar adenosine triphosphatase activity. All subjects showed a decline in peak torque with increasing velocities. Subjects with predominantly FT fibers were able to generate 11, 16, 23 and 47 percent greater relative peak torque than could predominantly ST subjects at lever arm velocities of 115, 200, 287 and 400 degrees/second respectively. Likewise the correlation between relative torque production and % FT were significant (p less than .05) and increased from r = 0.44 to r = 0.75 as velocity increased from 115 to 400 degrees/second respectively. These data suggest that muscle fiber composition becomes increasingly more related to power performance as the velocity of movement increases.
Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis (2007)

To identify genetic variants associated with outcome from chronic lymphocytic leukemia (CLL), we genotyped 977 nonsynonymous single nucleotide polymorphisms (nsSNPs) in 755 genes with relevance to cancer biology in 425 patients participating in a phase 3 trial comparing the efficacy of fludarabine, chlorambucil, and fludarabine with cyclophosphamide as first-line treatment. Selection of nsSNPs was biased toward those likely to be functionally deleterious. SNP genotypes were linked to individual patient outcome data and response to chemotherapy. The effect of genotype on progression-free survival (PFS) and overall survival (OS) was assessed by Cox regression analysis adjusting for treatment and clinico-pathologic variables. A total of 78 SNPs (51 dominantly acting and a further 27 recessively acting) were associated with PFS (9 also affecting OS) at the 5% level. These included SNPs mapping to the immune-regulation genes IL16 P434S (P = .03), IL19 S213F (P = .001), LILRA4 P27L (P = .004), KLRC4 S29I (P = .007), and CD5 V471A (P = .002); and DNA response genes POLB P242R (P = .04) and TOPBP1 S730L (P = .02), which were all independently prognostic of immunoglobulin heavy-chain variable region (IgV(H)) mutational status. The variants identified warrant further evaluation as promising prognostic markers of patient outcome. To facilitate the identification of prognostic markers through pooled analyses, we have made all data from our analysis publicly available.
A point mutation in the ectodomain‐transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors (2009)

ATP-gated P2X4 receptors (P2X4R) are abundantly expressed in the CNS. However, little is known about the molecular targets for ethanol action in P2X4Rs. The current investigation tested the hypothesis that the ectodomain-transmembrane (TM) interface contains residues that are important for the action of ethanol in P2X4Rs. Wild type (WT) and mutant P2X4R were expressed in Xenopus oocytes. ATP concentration-response curves and ethanol (10-200 mM)-induced changes in ATP EC(10)-gated currents were determined using two-electrode voltage clamp (-70 mV). Alanine substitution at the ectodomain-TM1 interface (positions 50-61) resulted in minimal changes in ethanol response. On the other hand, alanine substitution at the ectodomain-TM2 interface (positions 321-337) identified two key residues (D331 and M336) that significantly reduced ethanol inhibition of ATP-gated currents without causing marked changes in ATP I(max), EC(50), or Hill's slope. Other amino acid substitutions at positions 331 and 336 significantly altered or eliminated the modulatory effects of ethanol. Linear regression analyses revealed a significant relationship between hydropathy and polarity, but not molecular volume/molecular weight of the residues at these two positions. The results support the proposed hypothesis and represent an important step toward developing ethanol-insensitive receptors for investigating the role of P2X4Rs in mediating behavioral effects of ethanol.
A Li-Ion Battery Charger With Smooth Control Circuit and Built-In Resistance Compensator for Achieving Stable and Fast Charging (2009)

A built-in resistance compensator (BRC) technique is presented to speed up the charging time of a lithium-ion battery. A smooth control circuit (SCC) is proposed to ensure the stable transition from the constant-current (CC) to the constant-voltage (CV) stage. Due to the external parasitic resistance of the Li-ion battery-pack system, the charger circuit switches from the CC to the CV stage without fully charging the cell. The BRC technique dynamically estimates the external resistance to extend the CC stage. The experimental results show that the period of the CC stage can be extended to 40% of that of the original design. The charging time is effectively reduced.
SECC: Simultaneous extraction of context and community from pervasive signals (2016)

Understanding user contexts and group structures plays a central role in pervasive computing. These contexts and community structures are complex to mine from data collected in the wild due to the unprecedented growth of data, noise, uncertainties and complexities. Typical existing approaches would first extract the latent patterns to explain the human dynamics or behaviors and then use them as the way to consistently formulate numerical representations for community detection, often via a clustering method. While being able to capture highorder and complex representations, these two steps are performed separately. More importantly, they face a fundamental difficulty in determining the correct number of latent patterns and communities. This paper presents an approach that seamlessly addresses these challenges to simultaneously discover latent patterns and communities in a unified Bayesian nonparametric framework. Our Simultaneous Extraction of Context and Community (SECC) model roots in the nested Dirichlet process theory which allows nested structure to be built to explain data at multiple levels. We demonstrate our framework on three public datasets where the advantages of the proposed approach are validated.
1H-NMR analysis of CD3-ε reveals the presence of turn-helix structures around the ITAM motif in an otherwise random coil cytoplasmic tail (1997)

The conformation adopted in solution by the cytoplasmic tail of CD3-epsilon has been analyzed by 1H-nmr. The cytoplasmic tail is mostly random coil expect for the amino acids conforming the immunoreceptor tyrosine-based activation motif (ITAM), YxxL/IxxxxxxxY xxL. Although the N-terminal Y xxL sequence of the motif is poorly folded, adopting 6-residue turn-like conformations with the Tyr side chain in two different orientations, the C-terminal Y xxL sequence is placed in a more complex structure involving a set of nonclassical alpha-helix turns and beta-turns that comprises 11 amino acids. This structure is not modified by phosphorylation of the tyrosine residue. The differences in the conformation adopted around the two tyrosines of the ITAM motif suggest that they may play different roles pertaining to either binding signal transducing proteins or, alternatively, proteins involved in other processes such as endoplasmic reticulum location.
Global study on data compression techniques for digital Chinese character patterns (1992)

Dot matrix representation of Chinese characters is the most popular method used, however, it requires a relatively large memory for storage of Chinese character patterns. For the purpose of a global study, various data compression techniques are investigated to determine the method that requires the least amount of memory for data storage. The entropy of Chinese character patterns preprocessed using the two-dimensional prediction algorithm show the best results and appear almost independent of the subblock resolutions of m * n. Therefore, a possible bound of data compression for Chinese character patterns can be predicted. The data compression technique involving two-dimensional prediction preprocessing as well as arithmetic coding for sub-block symbols is found to be capable of achieving the best compression results for the 13,051 Chinese character patterns with various fonts in different resolutions.
Creating multi-layered structures with freestanding parts in SU-8 (2006)

This paper reports on a new method to create multi-layered structures with freestanding parts in SU-8. Examples of such structures are beams partially resting on a post or microchannels. The method, based on high-absorption UV light with a wavelength of 313 nm in SU-8, is fast, uses only traditional micromachining equipment and requires very few processing steps. It is well suited for thin freestanding layers (<15 µm). Furthermore, a variant of a method that uses a built-in UV blocking layer to enable freestanding structures is described in detail. This method has a broader application range in terms of the thickness of the freestanding parts. Both methods are applied to the fabrication of optical fiber clamps.