gebhart/patrepeval huggingface dataset:
A microtubule-interacting protein involved in coalignment of vimentin intermediate filaments with microtubules (1993)

A protein of M(r) 210,000 was identified in 3T3 cells by immunoblotting and by immunoprecipitation with a monoclonal antibody MA-01. The protein was thermolabile and was located on 3T3 microtubules prepared by taxol-driven polymerization in vitro. On fixed cells the MA-01 antigen was located on interphase and mitotic microtubular structures, vinblastine paracrystals, taxol bundles and colcemid-resistant microtubules. Microinjection experiments with purified MA-01 antibody followed by double immunofluorescence have shown that the injection of antibody led to disruption of vimentin filaments, whereas the distribution of cytoplasmic microtubules was unchanged. The collapse of vimentin filaments started 30 minutes after injecting the antibody at immunoglobulin concentrations 2 mg ml-1 or higher and reached its maximum 3-6 hours after the injection. Within 20 hours after the injection vimentin filaments became reconstituted. Microinjection of the antibody into cells pre-treated with vinblastine resulted in localization of the MA-01 antigen on vinblastine paracrystals as well as on coiled vimentin filaments. The data presented suggest that the MA-01 antigen is a new microtubule-interacting protein that mediates, directly or indirectly, an interaction between microtubules and vimentin intermediate filaments.
High-Temperature Plug Formation with Silicates (2005)

Abstract A grouting system is being developed that is applicable to water shutoff, steam flooding, and high-temperature grouting/plugging for lost circulation. This grouting system uses silicate hydrates as the plugging material. We describe a means to introduce sodium silicate and an activator through a single tubular by encapsulating the activator in a material that is temperature sensitive, thus delaying the initiation of the reaction. The formation of silicate hydrate plugs has been studied over the range of 80°C to 300°C as well as the chemical stability of silicate hydrate for 10-12 weeks.
MR fingerprinting using fast imaging with steady state precession (FISP) with spiral readout (2015)

Purpose This study explores the possibility of using gradient echo-based sequences other than balanced steady-state free precession (bSSFP) in the magnetic resonance fingerprinting (MRF) framework to quantify the relaxation parameters . Methods An MRF method based on a fast imaging with steady-state precession (FISP) sequence structure is presented. A dictionary containing possible signal evolutions with physiological range of T1 and T2 was created using the extended phase graph formalism according to the acquisition parameters. The proposed method was evaluated in a phantom and a human brain. T1, T2, and proton density were quantified directly from the undersampled data by the pattern recognition algorithm. Results T1 and T2 values from the phantom demonstrate that the results of MRF FISP are in good agreement with the traditional gold-standard methods. T1 and T2 values in brain are within the range of previously reported values. Conclusion MRF-FISP enables a fast and accurate quantification of the relaxation parameters. It is immune to the banding artifact of bSSFP due to B0 inhomogeneities, which could improve the ability to use MRF for applications beyond brain imaging. Magn Reson Med 74:1621–1631, 2015. © 2014 Wiley Periodicals, Inc.
Resolutive Candida utilis fungemia in a nonneutropenic patient (1993)

We report here the second case of Candida utilis infection in humans. The patient was apparently immunocompetent, had no central catheter, and survived an 8-day fungemia. Genomic analysis confirmed the conspecificity of medical and industrial strains of C. utilis and that of the anamorphic yeast C. utilis with the teleomorphic yeast Pichia jadinii.
Efficient Ambient and Emissive Tissue Illumination using Local Occlusion in Multiresolution Volume Rendering (2007)

This paper introduces a novel technique to compute illumination for Direct Volume Rendering. By adding shadow effects to volume rendered images, the perception of shapes and tissue properties can be significantly improved and it has the potential to increase the diagnostic value of medical volume rendering. The integrated intensity of incident light for a voxel is computed using a local approximation of the ambient occlusion, thus avoiding the rendering of tissues with very low illumination. Luminous tissue effects are also introduced to enhance the illumination model, controlled through an emissive component in the transfer function. This effect allows the user to highlight specific structures and can give a better understanding of tissue density. Multiresolution volume management and GPU-based computation is used to significantly speed-up the calculations and to support large data sets. The scheme yields interactive frame rates for incrementally refined ambient and emissive illumination for arbitrary transfer function changes.
A 249Mpixel/s HEVC video-decoder chip for Quad Full HD applications (2013)

The latest video coding standard High Efficiency Video Coding (HEVC) [1] provides 50% improvement in coding efficiency compared to H.264/AVC, to meet the rising demand for video streaming, better video quality and higher resolutions. The coding gain is achieved using more complex tools such as larger and variable-size coding units (CU) in a hierarchical structure, larger transforms and longer interpolation filters. This paper presents an integrated circuit which supports Quad Full HD (QFHD, 3840×2160) video decoding for the HEVC draft standard. It addresses new design challenges for HEVC (“H.265”) with three primary contributions: 1) a system pipelining scheme which adapts to the variable-size largest coding unit (LCU) and provides a two-stage sub-pipeline for memory optimization; 2) unified processing engines to address the hierarchical coding structure and many prediction and transform block sizes in area-efficient ways; 3) a motion compensation (MC) cache which reduces DRAM bandwidth for the LCU and meets the high throughput requirements which are due to the long filters.
Satellite-based AIS System Study (2008)

The Automatic Identification System (AIS) is a universal shipborne system aimed at improving the safety and efficiency of navigation and to help protecting the marine environment. Its main purpose is to facilitate an efficient exchange of messages between ships and between ships and shore stations. In this paper an extension of the system to a long range ship positioning reporting through a constellation of LEO satellites is presented. The technical challenges of such system including the high rate of message collisions from ships located in the field of view of a satellite are outlined. Technical solutions are proposed at system and sub-system level to cope with those challenges. A computer-based system simulator has been used to assess the system performance and carry out a high level overall system sizing.
Blocked diisocyanate polyester‐toughened novolak‐type phenolic resin: Synthesis, characterization, and properties of composites (1998)

A blocked diisocyanate polyester was synthesized to copolymerize with novolak-type phenolic resin. From the results of IR and NMR spectra, it was found that the blocked diisocyanate polyester reacts with the hydroxyl group of the novolak-type phenolic resin at high temperature. The deblocking temperature for the novolak-type phenolic resin is 120°C. The blocking agent, ε-caprolactam, is convenient for this system. The copolymer exhibited a single glass transition temperature and a negative deviation of the glass transition temperature. The results showed that the copolymer system is miscible and the molecular motion of the copolymer is increased with the addition of a modifier. The interface between the modified phenolic resin and the glass fiber is improved and the tensile strength of pultruded composite is increased with the modifier content. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 69: 1119–1127, 1998
Multiple serological biomarkers for colorectal cancer detection (2009)

The aim of this study was to initiate a survey of human autoantibody responses to a panel of select colorectal tumor-associated antigens identified by previous serological analysis of a cDNA expression library and to subsequently identify multiple serological biomarkers for the detection of colorectal cancer. For screening of autoantibodies against colorectal tumor-associated antigens, sera from 94 colorectal cancer patients and 54 normal controls were analyzed by enzyme-linked immunosorbent assay using recombinant rCCCAP, rHDAC5, rP53, rNMDAR and rNY-CO-16 proteins as coating antigens. Seropositivity among colorectal cancer patients to the 5 individual coating antigens varied from 18.1% to 35.1%. Seropositivity to any of the 5 coating antigens was 58.5% and combining this analysis with evaluation of serum carcinoembryonic antigen (> or =5 ng/ml) significantly increased the seropositivity to 77.6%. Seropositivity of early-stage (Dukes' Stages A and B) colorectal cancer patients to CEA was 21.9%, and seropositivity to any of the 5 colorectal cancer-associated antigens was 53.7%, and the combination of these 2 measurements resulted in a higher diagnostic capacity (65.9%) than either marker alone. In conclusion, these results collectively indicated that combined detection of serum autoantibody profiles against our panel of colorectal tumor-associated antigens and the analysis of carcinoembryonic antigen provides a promising diagnostic biomarker for colorectal cancer, particularly among early-stage patients.
Finite element analysis for prediction of bone strength (2013)

Finite element (FE) analysis has been applied for the past 40 years to simulate the mechanical behavior of bone. Although several validation studies have been performed on specific anatomical sites and load cases, this study aims to review the predictability of human bone strength at the three major osteoporotic fracture sites quantified in recently completed in vitro studies at our former institute. Specifically, the performance of FE analysis based on clinical computer tomography (QCT) is compared with the ones of the current densitometric standards, bone mineral content, bone mineral density (BMD) and areal BMD (aBMD). Clinical fractures were produced in monotonic axial compression of the distal radii, vertebral sections and in side loading of the proximal femora. QCT-based FE models of the three bones were developed to simulate as closely as possible the boundary conditions of each experiment. For all sites, the FE methodology exhibited the lowest errors and the highest correlations in predicting the experimental bone strength. Likely due to the improved CT image resolution, the quality of the FE prediction in the peripheral skeleton using high-resolution peripheral CT was superior to that in the axial skeleton with whole-body QCT. Because of its projective and scalar nature, the performance of aBMD in predicting bone strength depended on loading mode and was significantly inferior to FE in axial compression of radial or vertebral sections but not significantly inferior to FE in side loading of the femur. Considering the cumulated evidence from the published validation studies, it is concluded that FE models provide the most reliable surrogates of bone strength at any of the three fracture sites.
Distributed Translation Memories implementation using WebServices (2004)

Las memorias de traducción son muy útiles para la traducción, pero son difíciles de compartir y de reutilizar por parte de la comunidad de traductores. Mediante las memorias distribuidas de traducción, los usuarios pueden construir conjuntamente y compartir memorias de traducción. En este artículo, presentamos los detalles de la implementación de esta arquitectura utilizando la tecnología de WebServices y un ejemplo de un sistema distribuido entre Portugal y España.
Measuring Economic Resilience to Natural Disasters with Big Economic Transaction Data (2016)

This research explores the potential to analyze bank card payments and ATM cash withdrawals in order to map and quantify how people are impacted by and recover from natural disasters. Our approach defines a disaster-affected community's economic recovery time as the time needed to return to baseline activity levels in terms of number of bank card payments and ATM cash withdrawals. For Hurricane Odile, which hit the state of Baja California Sur (BCS) in Mexico between 15 and 17 September 2014, we measured and mapped communities' economic recovery time, which ranged from 2 to 40 days in different locations. We found that -- among individuals with a bank account -- the lower the income level, the shorter the time needed for economic activity to return to normal levels. Gender differences in recovery times were also detected and quantified. In addition, our approach evaluated how communities prepared for the disaster by quantifying expenditure growth in food or gasoline before the hurricane struck. We believe this approach opens a new frontier in measuring the economic impact of disasters with high temporal and spatial resolution, and in understanding how populations bounce back and adapt.
Vaccinia Virus DNA Replication Occurs in Endoplasmic Reticulum-enclosed Cytoplasmic Mini-Nuclei (2001)

Vaccinia virus (vv), a member of the poxvirus family, is unique among most DNA viruses in that its replication occurs in the cytoplasm of the infected host cell. Although this viral process is known to occur in distinct cytoplasmic sites, little is known about its organization and in particular its relation with cellular membranes. The present study shows by electron microscopy (EM) that soon after initial vv DNA synthesis at 2 h postinfection, the sites become entirely surrounded by membranes of the endoplasmic reticulum (ER). Complete wrapping requires ~45 min and persists until virion assembly is initiated at 6 h postinfection, and the ER dissociates from the replication sites. [(3)H]Thymidine incorporation at different infection times shows that efficient vv DNA synthesis coincides with complete ER wrapping, suggesting that the ER facilitates viral replication. Proteins known to be associated with the nuclear envelope in interphase cells are not targeted to these DNA-surrounding ER membranes, ruling out a role for these molecules in the wrapping process. By random green fluorescent protein-tagging of vv early genes of unknown function with a putative transmembrane domain, a novel vv protein, the gene product of E8R, was identified that is targeted to the ER around the DNA sites. Antibodies raised against this vv early membrane protein showed, by immunofluorescence microscopy, a characteristic ring-like pattern around the replication site. By electron microscopy quantitation the protein concentrated in the ER surrounding the DNA site and was preferentially targeted to membrane facing the inside of this site. These combined data are discussed in relation to nuclear envelope assembly/disassembly as it occurs during the cell cycle.
The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways. (1993)

While nasal cancer is relatively rare among the general population, workers in the nickel refining, leather manufacturing, and furniture building industries exhibit increased incidences of nasal cancer. To investigate the causes of nasal cancer and to design ameliorative strategies, an appropriate animal model for the human upper respiratory regions is required. The present report describes, compares, and assesses the anatomy and physiology of the nasal passages and upper airways of humans, rats, and monkeys for the purpose of determining a relevant animal model in which to investigate potential causes of nasal cancer. Based on the mode of breathing, overall geometry of the nasal passages, relative nasal surface areas, proportions of nasal surfaces lined by various epithelia, mucociliary clearance patterns, and inspiratory airflow routes, the rat, which is very different from humans, is a poor model. In contrast, the monkey exhibits many similarities to humans. Although the monkey does differ from humans in that it exhibits a more rapid respiratory rate, smaller minute and tidal volumes, larger medial turbinate, and a vestibular wing that creates an anterior vortex during inspiration, it offers a more appropriate model for studying the toxic effects of inhaled substances on the nasal passages and extrapolating the findings to humans.
Ice Nucleation Activity in <i>Fusarium acuminatum</i> and <i>Fusarium avenaceum</i> (1992)

Twenty fungal genera, including 14 Fusarium species, were examined for ice nucleation activity at -5.0 degrees C, and this activity was found only in Fusarium acuminatum and Fusarium avenaceum. This characteristic is unique to these two species. Ice nucleation activity of F. avenaceum was compared with ice nucleation activity of a Pseudomonas sp. strain. Cumulative nucleus spectra are similar for both microorganisms, while the maximum temperatures of ice nucleation were -2.5 degrees C for F. avenaceum and -1.0 degrees C for the bacteria. Ice nucleation activity of F. avenaceum was stable at pH levels from 1 to 13 and tolerated temperature treatments up to 60 degrees C, suggesting that these ice nuclei are more similar to lichen ice nuclei than to bacterial ones. Ice nuclei of F. avenaceum, unlike bacterial ice nuclei, pass through a 0.22-mum-pore-size filter. Fusarial nuclei share some characteristics with the so-called leaf-derived nuclei with which they might be identified: they are cell free and stable up to 60 degrees C, and they are found in the same kinds of environment. Highly stable ice nuclei produced by fast-growing microorganisms have potential applications in biotechnology. This is the first report of ice nucleation activity in free-living fungi.
Optimal geometric Hermite interpolation of curves (1998)

. Bernstein--B&apos;ezier two--point Hermite G 2 interpolants to plane and space curves can be of degree up to 5, depending on the situation. We give a complete characterization for the cases of degree 3 to 5 and prove that rational representations are only required for degree 3. x1. Introduction and Overview We consider recovery of curves from irregularly sampled data. If the curves are to be represented by NURBS, we want to generate representations which are minimal in the following sense: 1. they should have a minimal number of knots, 2. their degree should be as small as possible, 3. polynomial pieces are preferred over rational ones, and 4. the sampling and reconstruction process should be independent of the parametrization. Then evaluation algorithms are fast, and additional knot elimination will not be necessary. Furthermore, using minimal degrees usually helps to preserve shape properties. Within the above setting, this paper continues the presentation [14] given at the Biri conf...
Radiofrequency Field Quenching of Ultraviolet Excited Phosphors (1952)

The quenching action of radiofrequency field on ultraviolet excited phosphors has been investigated for a number of sulfide phosphors. The phosphor layer is sandwiched between two parallel plane electrodes. The radiofrequency potential is applied to the electrodes. Data are presented showing the dependence of the quenching action on field strength, field frequency, and ultraviolet excitation. The quenching response to an amplitude modulated rf potential, and the fatigue effects resulting from prolonged exposure to the rf field have also been investigated.
Distinction between<i>Clostridium botulinum</i>type A strains associated with food-borne botulism and those with infant botulism in Japan in intraintestinal toxin production in infant mice and some other properties (1991)

Two strains of Clostridium botulinum type A associated with food-borne botulism and six strains associated with infant botulism in Japan were compared in intraintestinal toxin production in infant mice, in vitro toxin and hemagglutinin production, molecular sizes of the toxins, and some other properties. The infant botulism-associated strains, producing M toxin (Mr 300 kDa) but no hemagglutinin, showed significantly lower 50% infective doses in infant mouse intestines. The antigenicities of the toxin differed between the two groups, while the biochemical properties of the cultures did not. Besides infant botulism-associated strains, this set of properties were found only in a strain isolated from honey of South American origin.
Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown (1981)

Macrophages were examined for immunoglobulin G (IgG) and albumin in actively demyelinating lesions in two patients with multiple sclerosis (MS) using the peroxidase-antiperoxidase immunocytochemical technique. In both cases, macrophages were present that stained for cytoplasmic or surface IgG or both. In one case, in which the tissue was rapidly fixed in chilled fixative, macrophages located among myelinated nerve fibers at plaque margins, but not elsewhere in the plaque, revealed surface IgG in the form of caps restricted to one or both poles of the cell. These caps were absent in sections stained for albumin. Because capping implies the presence of a multivalent ligand close to the cell surface and because cap formation was observed only in macrophages contacting myelin sheaths, we suggest that antimyelin antibody cytophilic for macrophages may be present in the central nervous system in MS, and that immune ligand-mediated phagocytosis may play a role in myelin breakdown in the disease. This study provides the first direct evidence that IgG participates locally in myelin breakdown in MS.
Control System Safety Evaluation and Reliability (1998)

This book is intended to serve a wide variety of users. This updated third edition provides the detailed background necessary to understand how to meet important new safety regulations and reliability engineering topics. Professional control system designers will learn to properly evaluate control system components, various system architectures, how to better communicate with vendors, and how to increase accuracy of life-cycle cost estimates. The book is also an excellent text for college courses due to its detailed explanations, practical presentation, and discussion of the difference between theory and real-world application. It provides a basic foundation of material, including probability, statistics, reliability theory definitions, and basic reliability modeling techniques, as well as advanced topics relevant to safety instrumented and control systems. Each chapter contains exercises to assist the reader in applying the theories presented with their practical implementation.
The first synthesis of N-acetylneuraminic acid 1,7-lactone (2008)

N-Acetylneuraminic acid is transformed into its until now unavailable and rather unwieldy 1,7-lactone, via the manageable 2-benzyloxycarbonyl N-acetylneuraminic acid 1,7-lactone which generates the free lactone in quantitative yield by hydrogenolysis.
Union bounds on the performance of product codes (2002)

We estimate the weight enumerator of a product code by using an exact expression for its known terms (e.g., the number of low weight words), and a binomial approximation for its unknown terms. We subsequently apply a union bound, using the estimated weight enumerator, to large product codes. The computed union bounds are similar to the simulation results of iterative (turbo) decoding of such codes as reported in literature.