gebhart/patrepeval huggingface dataset:
NAcSDKP Analogues Resistant to Angiotensin-Converting Enzyme (1997)

Two series of analogues of the tetrapeptide NAcSDKP, an inhibitor of hematopoietic stem cell proliferation, were prepared, and their enzymatic stability toward rabbit lung angiotensin-converting enzyme (ACE) was evaluated as well as their capacity to inhibit NAcSDKP hydrolysis by this enzyme. In the first series, each of the peptide bonds has been successively replaced by an aminomethylene bond. In the second one, the C-terminus of the peptide has been modified by decarboxylation or amidation. The results reported here indicate that all of these molecules but one have good stability toward the enzyme but none of the compounds is able to inhibit NAcSDKP hydrolysis by ACE.
An urgent house call (2001)

A home visit was requested urgently as an elderly lady had severe tingling in the face and arms, was developing weakness and was vomiting. The revised diagnosis was puffer fish poisoning. (non-author abstract)
Papierelektrophoretische Untersuchungen zur Einwirkung von Invertseifen auf Eiweißkörper (1953)

Untersucht man Eiweiß/Invertseifen-Mischungen mit Hilfe der Papierelektrophorese, so werden Umladungen der Eiweißkörper sichtbar. Es kommt zur Ausbildung von nach der Kathode wandernden Zonen, die definierten Eiweiß/Invertseifen-Verbindungen zugeordnet werden. Durch Dialyse, deren Verlauf papierelektrophoretisch kontrolliert wurde, sind solche Verbindungen wieder spaltbar. Man erhält neben der Invertseife denaturiertes Eiweiß zurück. Es wurden Trübung und Fällung von Eiweiß sowie Umladung und Ausbildung kathodischer Zonen in Abhängigkeit von der Konstitution der Invertseifen, des p H -Wertes und der Art des Eiweißkörpers untersucht.
A Genetic Algorithm for Packing Three-Dimensional Non-Convex Objects Having Cavities and Holes. (1997)

In this paper we describe a unique threedimensional bin-packing problem with nonconvex parts having holes and cavities. Parts can be arranged in any orientation and location in the packing cylinder, where parts float like in a weightless environment. The solution approach utilizes a genetic algorithm (GA) which represents a solution for the problem as a three-dimensional chromosome. Each dimension in the chromosome is an ordered list of integers. As a function evaluator we have developed a packing simulator, which utilizes actual CAD file of parts, when packing parts. Part intersection calculations are based on methods common in computational geometry. Keywords: genetic algorithms, 3D bin packing, nonconvex objects, selective laser sintering, rapid prototyping 1 INTRODUCTION 1.1 SELECTIVE LASER SINTERING RAPID PROTOTYPING TECHNOLOGY Like all current rapid prototyping (RP) techniques, the selective laser sintering (SLS) machine produces parts directly from CAD files through an addit...
Analogs of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents (1986)

The effect of a variety of aryl substituents on the potency and selectivity of 19 analogues of 1,3-dipropyl-8-phenylxanthine as antagonists at A1- and A2-adenosine receptors in brain tissue was determined. The 4-sulfamoylphenyl and 4-carbamoylphenyl analogues are potent and somewhat selective for the A1 receptor. None of the dihydroxyphenyl analogues are remarkably potent, but all are selective for the A1 receptor. 1,3-Dipropyl-8-(2-hydroxy-4-methoxyphenyl)xanthine is the most selective A1 antagonist of the analogues with a A1/A2 potency ratio of about 90.
Molecular and morphological characterisation of the Heterodera avenae species complex (Tylenchida: Heteroderidae) (2003)

Abstract Species of the Heterodera avenae complex, including populations of H. arenaria, H. aucklandica, H. australis, H. avenae, H. filipjevi, H. mani, H. pratensis and H. ustinovi, obtained from different regions of the world were analysed with PCR-RFLP and sequencing of the ITS-rDNA, RAPD and light microscopy. Phylogenetic relationships between species and populations of the H. avenae complex as inferred from analyses of 70 sequences of the ITS region and of 237 RAPD markers revealed that the cereal cyst nematode H. avenae is a paraphyletic taxon. The taxonomic status of the Australian cereal cyst nematode H. australis based on sequences of the ITS-rDNA and RAPD data is confirmed. Morphometrical and ITS-rDNA sequence analyses revealed that the Chinese cereal cyst nematode is different from other H. avenae populations infecting cereals and is related to H. pratensis. Bidera riparia Kazachenko, 1993 is transferred to the genus Heterodera as H. riparia (Kazachenko, 1993) comb. n. As a consequence, H. riparia Subbotin, Sturhan, Waeyenberge & Moens, 1997 becomes a junior secondary homonym and is renamed as H. ripae nom. nov. Morphological, morphometrical characters and RFLP profiles for identification of the nine species presently placed in the H. avenae species complex are given.
Transarterial Radioembolization with Yttrium-90 for Regional Management of Hepatocellular Cancer: The Early Results of a Nontransplant Center (2010)

Selective arterial radioembolization with Yttrium-90 (Y-90) microspheres has shown promise for regional management of hepatocellular cancer (HCC). Our objective was to report our early experience with this treatment modality from a nontransplant center. Treatment of patients with HCC was discussed in a multidisciplinary tumor board. Patients with unresectable disease resulting from high lesion number, ill location of the tumor, poor hepatic reserve, or medical comorbidities were offered Y-90 treatment. Liver treatment was either lobar or tumor-targeted. Response to therapy was assessed by CT scan obtained within 3 months using Response Evaluation Criteria in Solid Tumors criteria. During 2007 to 2009, 40 Y-90 radioembolizations were performed in 20 patients with age that ranged from 16 to 87 years; four patients were 80 years old or older. After the first therapy, CT assessment of the treated area showed stable disease (n=15), partial response (n=3), and progression (n=2). Of the two patients who progressed, one was retreated with a subsequent complete response. The other patient died of progressive disease. The most common side effects were mild fatigue, anorexia, and nausea. In summary, our nontransplant center experience shows that Y-90 radioembolization is a well-tolerated treatment in select patients with unresectable HCC with an associated high rate of local tumor control.
The superior laryngeal nerve. (1976)

Injury to the internal (sensory) branch of the superior laryngeal nerve during thyroidectomy is unlikely. Signs of injury are loss of sensation in the upper larynx, resulting in choking and aspiration of swallowed fluids. Injury to the external (motor) branch of the superior laryngeal nerve produces no problem of respiration, but may result in changes in the quality of the voice or even voicelessness. Injury to the external branch can be avoided if the anatomical variations are kept in mind during ligation of upper pole vessels.
Cytokines in the Progression of Pancreatic<i>β</i>-Cell Dysfunction (2010)

The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function. Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β-cell function. The change in cytokine profile in islet and plasma is associated with pancreatic β-cell dysfunction and apoptosis. In this paper, we summarize and discuss the recent studies on the effects of certain important cytokines on pancreatic β-cell function. The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β-cell dysfunction under insulin-resistant conditions.
X-linked bulbospinal neuronopathy: Kennedy disease. (2002)

Our data show that KD is a multisystem disorder with onset in adolescence. Because of the heterogeneity of clinical presentation and no correlation between the number of CAG repeats and most of the clinical hallmarks of KD, we suggest that other environmental or genetic factors contribute to the manifestation of specific organ systems in KD.
Big Boy Blue (1915)

Essay| October 01 1915 Big Boy Blue Jessie Pope Jessie Pope Search for other works by this author on: This Site PubMed Google Scholar Current History (1915) 3 (1): 140. https://doi.org/10.1525/curh.1915.3.1.140a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jessie Pope; Big Boy Blue. Current History 1 October 1915; 3 (1): 140. doi: https://doi.org/10.1525/curh.1915.3.1.140a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1915 by The Regents of the University of California1915 Article PDF first page preview Close Modal You do not currently have access to this content.
Increase in Na Pump Activity of Brain-type Isoforms via Increased Turnover Rate after Glutamate Excitation of Cerebral Neurons (1994)

Na+/K+-ATPase (=Na pump) is abundant in nervous tissue and plays an important role in neuronal excitation by producing sodium and potassium ion-gradients across the cell membrane. Isoforms of Na+/K+-ATPase are known to exist in brain. Highly ouabain-sensitive isoform (brain-type; α2 and α3) appeared and increased during the maturation of primary cultured rat cerebral neurons besides the weakly ouabain-sensitive isoform pre-existing (common-type; α1) (1). We demonstrated that the Na pump activity of brain-type isoform in the matured neurons increased several folds after glutamate excitation while the activity of common-type isoform decreased slightly (2,3). To discriminate whether the increase in Na pump activity is due to increase in number or turnover rate of the pump, the number of Na pump was determined by [3H]ouabain binding experiment.
A Chiral Phenoxyamine Magnesium Catalyst for the Enantioselective Hydroamination/Cyclization of Aminoalkenes and Intermolecular Hydroamination of Vinyl Arenes (2011)

If Grignard had only known! A chiral magnesium complex catalyzes the intramolecular hydroamination/cyclization of aminoalkenes with high efficiency at temperatures as low as −20 °C and enantioselectivities as high as 93 % ee. The high activity of this system also allows the catalytic intermolecular anti-Markovnikov addition of pyrrolidine and benzylamine to vinyl arenes.
Action of Pyridine and Iodine upon Two o-Phenolic-1,4-diketones: 4,6,7-Trimethylcoumarandione and its 5-Hydroxy Derivative (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAction of Pyridine and Iodine upon Two o-Phenolic-1,4-diketones: 4,6,7-Trimethylcoumarandione and its 5-Hydroxy DerivativeLee Irvin Smith and Richard Remsen HolmesCite this: J. Am. Chem. Soc. 1951, 73, 9, 4294–4297Publication Date (Print):September 1, 1951Publication History Published online1 May 2002Published inissue 1 September 1951https://pubs.acs.org/doi/10.1021/ja01153a078https://doi.org/10.1021/ja01153a078research-articleACS PublicationsRequest reuse permissionsArticle Views703Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mobile Robot with Preliminary-Announcement and Indication of Scheduled Route and Occupied Area Using Projector (2008)

In the questionnaire evaluation (Matsumaru, 2007b), PMR-5 has received the highest evaluation score comparing with other three prototype robots, eyeball robot PMR-2 (Matsumaru et al, 2003a, 2003b; Matsumaru et al, 2005), arrow robot PMR-6 (Matsumaru et al, 2001; Matsumaru, 2007a), and light ray robot PMR-1. In the experimental examination in simulated interactive situation between people and robot, the passing each
Cross-camera vehicle tracking via affine invariant object matching for video forensics applications (2013)

The recent deployment of very large-scale camera networks consisting of fixed/moving surveillance cameras and vehicle video recorders, has led to a novel field in object tracking problem. The major goal is to detect and track each vehicle within a large area, which can be applied to video forensics. For example, a suspected vehicle can be automatically identified for mining digital criminal evidences from a large amount of video data. In this paper, we propose an efficient cross-camera vehicle tracking technique via affine invariant object matching. More specifically, we formulate the problem as invariant image feature matching among different viewpoints of cameras. To achieve vehicle matching, we first extract invariant image feature based on ASIFT (affine and scale-invariant feature transform) for each detected vehicle in a camera network. Then, to improve the accuracy of ASIFT feature matching between images from different viewpoints, we propose to efficiently match feature points based on our observed spatially invariant property of ASIFT, as well as the min-hash technique. As a result, cross-camera vehicle tracking can be efficiently and accurately achieved. Experimental results demonstrate the efficacy of the proposed algorithm and the feasibility to video forensics applications.
Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis (2004)

In this review, metabonomics, a combination of data-rich analytical chemical measurements and chemometrics for profiling metabolism in complex systems, is described and its applications are reviewed. Metabonomics is typically carried out using biofluids or tissue samples. The relevance of the technique is reviewed in relation to other '-omics', and it is shown how the methods can be applied to physiological evaluation, drug safety assessment, characterization of genetically modified animal models of disease, diagnosis of human disease, and drug therapy monitoring. The different types of analytical data, mainly from nuclear magnetic resonance spectroscopy and mass spectrometry, are summarized. The outputs from a metabonomics study allow sample classification, for example according to phenotype, drug safety or disease diagnosis, and interpretation of the reasons for classification yields information on combination biomarkers of effect. Transcriptomic and metabonomic data is currently being further integrated into a holistic understanding of systems biology. An assessment of the possible future role and impact of metabonomics is presented.
Biochemical and structural characterization of a novel bacterial manganese‐dependent hydroxynitrile lyase (2013)

Hydroxynitrile lyases (HNLs), which catalyse the decomposition of cyanohydrins, are found mainly in plants. In vitro, they are able to catalyse the synthesis of enantiopure cyanohydrins, which are versatile building blocks in the chemical industry. Recently, HNLs have also been discovered in bacteria. Here, we report on the detailed biochemical and structural characterization of a hydroxynitrile lyase from Granulicella tundricola (GtHNL), which was successfully heterologously expressed in Escherichia coli. The crystal structure was solved at a crystallographic resolution of 2.5 Å and exhibits a cupin fold. As GtHNL does not show any sequence or structural similarity to any other HNL and does not contain conserved motifs typical of HNLs, cupins represent a new class of HNLs. GtHNL is metal-dependent, as confirmed by inductively coupled plasma/optical emission spectroscopy, and in the crystal structure, manganese is bound to three histidine and one glutamine residue. GtHNL displayed a specific activity of 1.74 U·mg(-1) at pH 6 with (R)-mandelonitrile, and synthesized (R)-mandelonitrile with 90% enantiomeric excess at 80% conversion using 0.5 m benzaldehyde in a biphasic reaction system with methyl tertiary butyl ether.
INDUCTION OF TNFα AND TNFβ GENE EXPRESSION IN RAT CARDIAC TRANSPLANTS DURING ALLOGRAFT REJECTION (1993)

The expression of the cytotoxic cytokines tumor necrosis factor alpha and TNF beta or lymphotoxin (LT) was assessed in rat cardiac transplants during rejection. Newborn rat cardiac grafts placed in adult rat ear pinnae were retrieved on days 1 through 10 posttransplantation; the average time to rejection, assessed by the absence of detectable electrocardiographic activity, was determined to be 7 days. Total cellular RNA and tissue homogenates were prepared from cardiac transplants in order that relative levels of TNF alpha and LT mRNA and TNF protein could be determined. A biphasic pattern of TNF alpha gene expression was consistently seen in cardiac allografts. TNF alpha mRNA transcripts were detected as early as day 2 post-tx, with peak levels appearing on day 3 post-tx. Although transcript levels decreased by day 4, a significant increase appeared again on day 6 post-tx, coincident with the onset of rejection. Similar to TNF alpha gene expression, LT transcripts demonstrated a biphasic pattern of induction. LT mRNA transcripts also reached peak levels on day 3 post-tx, with a second increase in transcript levels coincident with rejection. TNF protein levels in allografts displayed a biphasic pattern, similar to that shown by the cytokine mRNAs. Peak levels of TNF protein were detected on day 3 post-tx, with a second increase again coinciding with rejection. In contrast to TNF expression found in allografts, TNF alpha and LT mRNA transcripts were not detected in isografts on days 1 through 10 post-tx. TNF protein levels in cardiac isografts were consistently at or below the standard limits of detection, and on days 3 through 7 post-tx were significantly reduced (P < or = 0.001) when compared with time-matched allografts. Increased expression of the cytotoxic cytokines TNF alpha and LT, therefore, appears to be allograft-specific and is an early event during rat cardiac allograft rejection. In conclusion, induction of TNF gene expression may be an important early indicator of transplant rejection.
Spextool: A Spectral Extraction Package for SpeX, a 0.8–5.5 Micron Cross‐Dispersed Spectrograph (2004)

We describe an IDL‐based package for the reduction of spectral data obtained with SpeX, a medium‐resolution, 0.8–5.5 μm cross‐dispersed spectrograph and imager for the NASA Infrared Telescope Facility. The package, called Spextool, carries out all the procedures necessary to produce fully reduced spectra including preparation of calibration frames, processing and extraction of spectra from science frames, wavelength calibration of spectra, and flux calibration of spectra. The package incorporates an "optimal extraction" algorithm for point‐source data and also generates realistic error arrays associated with the extracted spectra. Because it is fairly quick and easy to use, requiring minimal user interaction, Spextool can be run by observers at the telescope to estimate the signal‐to‐noise ratio of their data. We describe the procedures incorporated into Spextool and show examples of extracted spectra.
DNA-directed assembly of protein microarrays (2008)

Microarray technology has made it possible to simultaneously study the abundance, interactions, and functions of potentially tens of thousands of biological molecules. From its earliest use in DNA microarrays, where only nucleic acids were captured and detected on the arrays, applications of microarrays now extend to those involving biomolecules such as antibodies, proteins, peptides, and carbohydrates. In contrast to the relative robustness of DNA microarrays, the use of such chemically diverse biomolecules on microarray formats presents many challenges in their fabrication as well as application. Among the many methods that have been proposed to overcome these challenges, DNA-directed assembly (DDA) has emerged as a promising strategy for the high sensitivity and multiplexed capture and detection of various analytes. In this review, we explore the challenges faced during the design, fabrication, and utilization of protein microarrays and highlight how DDA strategies, together with other recent advances in the field, are accelerating the development of platforms available for protein microarray applications.
Is Title VI a Magic Bullet? Environmental Racism in the Context of Political-Economic Processes and Imperatives (1996)

This Article examines avenues of redress and pollution prevention for impoverished people of color that flow from Title VI litigation strategies within the larger context of the environmental justice movement. Environmental justice issues can serve as tools with which to question status quo distributive policymaking processes and outcomes. Specifically, this Article concerns itself with practical routes toward increasing distributive justice and democratic efficacy.
Therapeutic value of 21-aminosteroid U74389F in acute spinal cord injury (1993)

The effect of bolus injections of 21-aminosteroid U74389F after an acute spinal cord compression trauma in rats was studied. Cortical somatosensory evoked potentials (CSEPs) were recorded before and after a weight-induced injury of 120 g and monitored up to five hours post-injury. All U74389F treatments were given as i.v. bolus injections of 15, 7.5, and 3.75 mg kg-1 at 1, 2, 3 h after the trauma, respectively. The CSEPs were abolished immediately after the injury in the control and treated animals. The majority of the treated animals (88.8%) demonstrated a return of the CSEPs within the second hour post-injury. In contrast, the animals in the control group showed only 44.4% recovery at this time period. At three hours post-injury, U74389F-treated animals (n = 18) showed a full recovery (100%) while the recovery rate remained at 44.4% for the control animals. We conclude that the bolus administration of U74389F one hour after injury facilitates the return of the spinal cord function as measured by the CSEPs in this compression model of acute spinal cord trauma.