gebhart/patrepeval huggingface dataset:
Application of wavelet transforms to compression of mechanical vibration data (1998)

To detect abnormality of rotating machines in factories and power generating plants, the vibration data of the machines are used as a guide to express abnormal phenomena. In order to improve the diagnostic accuracy of the rotating machine diagnostic system, the storage and analysis of a large amount of vibration data is important. For efficient data storage and transmission, data compression is indispensable. In this paper, with a view to reducing data storage capacity and the transmission capacity in the rotating machine diagnostic system, compression of machine vibration data is attempted. In the proposed compression system, wavelet transforms are used so that the distortion generated in compression and reconstruction have minimal effect on the diagnostics. Considering the mode of system usage, a compression system is proposed that maximizes the compression ratio at allowable distortions. In order to evaluate the overall performance of the proposed compression system, data compression by several orthogonal wavelets composed of Daubechies bases and those generated by DCT (discrete cosine transform) are compared. It is shown that the system using the wavelet with a higher-order tap has the highest compression performance and that the compression factor is about 3 to 8 in the allowable distortion range of 1 to 10%. © 1998 Scripta Technica, Electron Comm Jpn Pt 3, 81(10): 16–25, 1998
Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension (2007)

Compound 7 was identified as a potent (IC50 = 14 nM), selective, and orally bioavailable (F = 70% in mouse) inhibitor of protein kinase B/Akt. While promising efficacy was observed in vivo, this compound showed effects on depolarization of Purkinje fibers in an in vitro assay and CV hypotension in vivo. Guided by an X-ray structure of 7 bound to protein kinase A, which has 80% homology with Akt in the kinase domain, our efforts have focused on structure-activity relationship (SAR) studies of the phenyl moiety, in an attempt to address the cardiovascular liability and further improve the Akt potency. A novel and efficient synthetic route toward diversely substituted phenyl derivatives of 7 was developed utilizing a copper-mediated aziridine ring-opening reaction as the key step. To improve the selectivity of these Akt inhibitors over other protein kinases, a nitrogen atom was incorporated into selected phenyl analogues of 7 at the C-6 position of the methyl indazole scaffold. These modifications resulted in the discovery of inhibitor 37c with greater potency (IC50 = 0.6 nM vs Akt), selectivity, and improved cardiovascular safety profile. The SARs, pharmacokinetic profile, and CV safety of selected Akt inhibitors will be discussed.
Observation of a Metastability Limit in Liquid Gallium (1975)

We report neutron-scattering measurements on highly supercooled liquid gallium droplets showing a vanishing quasi-elastic frequency width as the temperature is reduced. The width tends towards zero at a temperature within 1 standard deviation of the value ${T}_{L}=150\ifmmode\pm\else\textpm\fi{}1$ K at which gallium is always observed to become crystalline. This suggests the interpretation of ${T}_{L}$ as a metastability limit, below which the liquid state becomes unstable with respect to infinitesimal fluctuations.
Structure and organization of a cluster of sic tRNA genes in the space between tandem ribosomal RNA gene sets in Bacillus subtilis. (1983)

Hybridization of Southern blots of EcoRI digests of total Bacillus subtilis DNA with ribosomal RNA and transfer RNA probes provides evidence of highly clustered tRNA and rRNA genes, with several tRNA clusters being located in spaces which span between tandem ribosomal RNA gene sets. Clones containing these tRNA clusters were isolated from a Charon 4A library. One of them, denoted trrnB, was partially sequenced. A cluster of six tRNA genes was found, with anticodon assignments of Asn, Thr, Gly, Arg, Pro, Ala. This cluster is closely flanked on both sides by ribosomal RNA gene sets, which were identified by sequencing upward through the 5 S rRNA gene, across a space, and into the 23 S rRNA gene, and also sequencing downward into the 16 S rRNA gene. The tRNA gene cluster appears to be organized into at least two transcriptional units separated by an attenuator region. These transcriptional units may be components of the flanking ribosomal RNA operons. The putative promoter region of the downstream 16 S rRNA is organized differently from Escherichia coli; it is smaller and seems less complex. This gene organization provides insight into possible mechanisms for coordinate and differential control of transfer and ribosomal RNA gene expression.
Color image processing in a cellular neural-network environment (1996)

When low-level hardware simulations of cellular neural networks (CNNs) are very costly for exploring new applications, the use of a behavioral simulator becomes indispensable. This paper presents a software prototype capable of performing image processing applications using CNNs. The software is based on a CNN multilayer structure in which each primary color is assigned to a unique layer. This allows an added flexibility as different processing applications can be performed in parallel. To be able to handle a full range of color tones, two novel color mapping schemes were derived. In the proposed schemes the color information is obtained from the cell's state rather than from its output. This modification is necessary because for many templates CNN has only binary stable outputs from which only either a fully saturated or a black color can be obtained. Additionally, a postprocessor capable of performing pixelwise logical operations among color layers was developed to enhance the results obtained from CNN. Examples in the areas of medical image processing, image restoration, and weather forecasting are provided to demonstrate the robustness of the software and the vast potential of CNN.
Quantitative Real-time RT-PCR Detection for Survivin, CK20 and CEA in Peripheral Blood of Colorectal Cancer Patients (2008)

The combined use of negative and positive immunomagnetic beads followed by amplification of survivin, CK20 and CEA mRNA by means of qRT-PCR is a non-invasive and sensitive assay for the detection of circulating CRC cells. The combined panel improved the sensitivity of detection in CRC patients.
[Studies on chemical constituents of flavonoid from Verbena officinals]. (2006)

Five compounds have been isolated from Verbena offcinals L. On the basis of spectral analysis and physicochemical properties, the compounds were identified as luteolin (1), kaempferol (2), quercetin (3), apigenin (4) and 4'-hydroxywogonin (5). 1, 2 and 3 were obtained from the genus for the first time.
Mechanics of pulmonary circulation in isolated rabbit lungs (1959)

A new method has been devised for measuring the compliance (volume change ÷ pressure change) of the pulmonary arterial tree (down to the capillaries), in isolated, Krebs-Ringer-perfused rabbit lungs. The lungs were suspended in a plethysmograph and inflated with N 2 O. Fluid was introduced into the pulmonary artery by a motor driven syringe and the volume injected was recorded. The capillary flow was deduced from the plethysmograph pressure change which resulted from N 2 O uptake. Vascular volume change equaled arterial inflow minus outflow into capillaries. The compliance of the venous tree was similarly measured by retrograde perfusion. Mean compliance of the pulmonary arterial tree was 0.17 (S.E. 0.02) ml/cm H 2 O in six rabbits, mean weight, 4.4 kg. Mean compliance of the pulmonary venous tree was 0.41 (S.E. 0.03) ml/cm H 2 O in five rabbits, mean weight, 4.3 kg. Compliance of the whole bed (not including the left atrium) was 0.69 (S.E. 0.06) ml/ cm H 2 O in six rabbits, mean weight, 4.4 kg. Equations were derived relating the length, diameter and number of vessels in the vascular bed. From these the inertance of the blood in the pulmonary arterial tree was estimated to be 8 gm cm –4 in rabbit lungs and 1 gm cm –4 in human lungs. The flow response to sinusoidal pressure waves of different frequencies was calculated, assuming a system with lumped compliance, inertance and resistance. The input impedance of the pulmonary vascular bed, in the rabbit and in man, was minimum for a frequency midway between the fundamental frequency and the second harmonic of the resting heart rate.
The aminoacylation of transfer ribonucleic acid. Inhibitory effects of some amino acid analogues with altered side chains (1976)

Several amino acid analogues that are able to replace amino acid residues in binding positions of the biologically active C-terminal tetrapeptide amide sequence, Trp-Met-Asp-PheNH2, of the gastrins were examined for their ability to inhibit the aminoacylation of tRNA in an Escherichia coli and rat liver system. Although in both systems the amino acid side chains are involved in the recognition process, the structural requirements of the side chain in the two systems are not comparable. Analogues of methionine and phenylalanine behaved similarly in the E. coli and rat liver systems, whereas analogues of tryptophan behaved differently. From the results it is possible to suggest structural features of the amino acid side chains which are required for recognition by the aminoacyl-tRNA synthetases.
Ovarian Mixed-Epithelial Carcinomas With a Microcystic Pattern and Signet-Ring Cells (2001)

Primary ovarian carcinomas with unusual histologic patterns can be difficult to differentiate from metastases. In this study, we reviewed 15 cases of mixed-epithelial carcinoma (12 serous, 1 serous and endometrioid, 1 endometrioid, 1 undifferentiated) with a predominant microcystic pattern and signet-ring cells. The patients' ages ranged from 31 to 78 (mean 58) years. The microcystic component in 11 patients had features of high-grade carcinoma and in 4 patients had features of low-grade carcinoma associated with areas of borderline tumor. The tumors in all 15 patients showed a predominant microcystic growth pattern composed of small cysts that were variable in size and shape. Signet-ring cells were also present in all cases (diffusely in nine cases, focally in six cases) within the neoplastic epithelial proliferation. Mucin was present in the lumina of some of the microcysts and in the cytoplasm of most of the signet-ring cells. A microcystic pattern and mucin-containing signet-ring cells can be seen as small foci or as a predominant component in primary epithelial nonmucinous ovarian carcinomas. It is important for pathologists to recognize these unusual findings in ovarian neoplasms, because they may produce a confusing apperance, even potentially suggesting a metastasis.
An Experimental Study on Selection Method of Vari-Speed Milling Parameters (2010)

This paper investigates the selection method of vari-speed milling parameters by experiments. The orthogonal experiments of vari-speed milling were studied on a given speed according to the stability lobes, and various parameters were selected. The experimental results show that varying speed milling approach possesses effects on vibration suppression on proper parameters selection though the acceleration damping ratio γa and the sound damping ratio γs. The variance analysis of dual factors test is adopted to data process and the acceleration damping ratio γa is taken as the evaluation index of vibration suppression. Finally, the preliminary conclusions on how to select proper parameters are obtained on the basis of the analysis of the experimental results, which is applied to online monitoring techniques using vibration to achieve automatic control of variable speed cutting.
Efficient high-frequency soft-switched power converter with signal processor control (2002)

DC/AC high-power, high-density converter structures and topologies are evaluated. The direct DC-low frequency-AC structure with the dual active bridge (DAB) topology is selected together with insulated gate bipolar transistor (IGBT) switches at 100 kHz, 20 kVA. A novel control strategy for the DAB and series-loaded resonant converters is introduced. It gives the possibility of fixed-frequency, zero voltage switching in the entire converter output V-I-plane. Design equations are presented. A method for comparing topologies by mapping stress levels in the output V-I plane is demonstrated. Experimental results from a small-scale model are shown, with good correspondence to simulation waveforms. The converter will be driven by an IBM PC/MS Windows based control system, of which the core is a 32-b digital signal processor connected to a programmable gate array holding all switch control circuitry.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Impact of source spontaneous emission (SSE) on the measurement of DWDM components (2002)

We demonstrate the use of a tunable laser source with strongly reduced source spontaneous emission (SSE) when applied to critical DWDM-components.
Identification of a residue in the γ‐aminobutyric acid type A receptor α subunit that differentially affects diazepam‐sensitive and ‐insensitive benzodiazepine site binding (2004)

GABAA receptors that contain either the alpha4- or alpha6-subunit isoform do not recognize classical 1,4-benzodiazepines (BZDs). However, other classes of BZD site ligands, including beta-carbolines, bind to these diazepam-insensitive receptor subtypes. Some beta-carbolines [e.g. ethyl beta-carboline-3-carboxylate (beta-CCE) and methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM)] display a higher affinity for alpha4- compared to alpha6-containing receptors. In order to identify the structural determinants that underlie these affinity differences, we constructed chimeric alpha6/alpha4 subunits and co-expressed these with wild-type rat beta2 and gamma2L subunits in tsA201 cells for radioligand binding analysis. After identification of candidate regions, site-directed mutagenesis was used to narrow the ligand selectivity to a single amino acid residue (alpha6N204/alpha4I203). Substitutions at alpha6N204 did not alter the affinity of the imidazobenzodiazepine Ro15-4513. A homologous mutation in the diazepam-sensitive alpha1 subunit (S205N) resulted in a 7-8-fold reduction in affinity for the beta-carbolines examined. Although the binding of the classical agonist flunitrazepam was relatively unaffected by this mutation in the alpha1 subunit, the affinity for Ro15-1788 and Ro15-4513 was decreased by approximately 19-fold and approximately 38-fold respectively. The importance of this residue, located in the Loop C region of the extracellular N-terminus of the subunit protein, emphasizes the differential interaction of ligands with the alpha subunit in diazepam-sensitive and -insensitive receptors.
Tris-Nitrilotriacetic Acids of Subnanomolar Affinity Toward Hexahistidine Tagged Molecules (2009)

Nitrilotriacetic acid (NTA) has moderate affinity (10 μM) for hexahistidine (His6) and is widely used in the purification of His6-tagged proteins. The affinity can be increased significantly (10 nM) through multivalency such as using a tris-NTA. We show that the binding affinity of tris-NTA is dependent on the flexibility and length of the spacer between the mono-NTA and the scaffold: the shorter the spacer, the higher the affinity. A series of biotinylated tris-NTA having different spacers were synthesized and used to prepare tris-NTA sensor chips for surface plasmon resonance measurement of binding affinity. Subnanomolar affinity can be achieved with a short spacer. The new high-affinity tris-NTA enables the formation of stable complexes with hexahistidine containing molecules and provides a convenient method to noncovalently attach proteins to various surfaces.
Using a novel behavioral stimuli-response framework to Defend against Adversarial Cyberspace Participants (2011)

Participants (ABCD-ACP) is an experimental defensive framework against potentially adversarial cyberspace participants, such as malicious software and subversive insiders. By deploying fake targets (called baits/stimuli) onto a virtualized environment, the framework seeks to probabilistically identify suspicious participants through aggregate suspicious behavior, subvert their decision structure and goad them into a position favorable to the defense. Baits include simulating insertion of readable and writable drives with weak or no password, marked doc/pdf/txt/exe/cad/xls/dat files, processes with popular target names and processes that detect thread injections. This approach bears some similarities to the concept of subverting an enemy&apos;s OODA (Observe, Orient, Decide, and Act) loop, an information warfare strategy which seeks to proactively influence and change enemy behavior. By controlling perception of the environment, this approach similarly seeks to influence adversarial participants’ decision complexity, noise levels, effectiveness and ultimately their ability to fulfill their mission. This is a work in progress: The conceptual framework is described, and implemented baits and preliminary empirical results are presented.
Brain α‐Ketoglutarate Dehydrogenase Complex: Kinetic Properties, Regional Distribution, and Effects of Inhibitors (1986)

The substrate and cofactor requirements and some kinetic properties of the alpha-ketoglutarate dehydrogenase complex (KGDHC; EC 1.2.4.2, EC 2.3.1.61, and EC 1.6.4.3) in purified rat brain mitochondria were studied. Brain mitochondrial KGDHC showed absolute requirement for alpha-ketoglutarate, CoA and NAD, and only partial requirement for added thiamine pyrophosphate, but no requirement for Mg2+ under the assay conditions employed in this study. The pH optimum was between 7.2 and 7.4, but, at pH values below 7.0 or above 7.8, KGDHC activity decreased markedly. KGDHC activity in various brain regions followed the rank order: cerebral cortex greater than cerebellum greater than or equal to midbrain greater than striatum = hippocampus greater than hypothalamus greater than pons and medulla greater than olfactory bulb. Significant inhibition of brain mitochondrial KGDHC was noted at pathological concentrations of ammonia (0.2-2 mM). However, the purified bovine heart KGDHC and KGDHC activity in isolated rat heart mitochondria were much less sensitive to inhibition. At 5 mM both beta-methylene-D,L-aspartate and D,L-vinylglycine (inhibitors of cerebral glucose oxidation) inhibited the purified heart but not the brain mitochondrial enzyme complex. At approximately 10 microM, calcium slightly stimulated (by 10-15%) the brain mitochondrial KGDHC. At concentrations above 100 microM, calcium (IC50 = 1 mM) inhibited both brain mitochondrial and purified heart KGDHC. The present results suggest that some of the kinetic properties of the rat brain mitochondrial KGDHC differ from those of the purified bovine heart and rat heart mitochondrial enzyme complexes. They also suggest that the inhibition of KGDHC by ammonia and the consequent effect on the citric acid cycle fluxes may be of pathophysiological and/or pathogenetic importance in hyperammonemia and in diseases (e.g., hepatic encephalopathy, inborn errors of urea metabolism, Reye's syndrome) where hyperammonemia is a consistent feature. Brain accumulation of calcium occurs in a number of pathological conditions. Therefore, it is possible that such a calcium accumulation may have a deleterious effect on KGDHC activity.
A synthetic model for the oxygen-evolving complex in Sr<sup>2+</sup>-containing photosystem II (2014)

A novel heterometallic MnSr complex containing the Mn3SrO4 cuboidal moiety and all types of μ-O(2-) moieties observed in the oxygen-evolving complex (OEC) in Sr(2+)-containing photosystem II (PSII) has been synthesized and characterized, which provides a new synthetic model of the OEC.
Postharvest treatments of fresh produce (2014)

Postharvest technologies have allowed horticultural industries to meet the global demands of local and large-scale production and intercontinental distribution of fresh produce that have high nutritional and sensory quality. Harvested products are metabolically active, undergoing ripening and senescence processes that must be controlled to prolong postharvest quality. Inadequate management of these processes can result in major losses in nutritional and quality attributes, outbreaks of foodborne pathogens and financial loss for all players along the supply chain, from growers to consumers. Optimal postharvest treatments for fresh produce seek to slow down physiological processes of senescence and maturation, reduce/inhibit development of physiological disorders and minimize the risk of microbial growth and contamination. In addition to basic postharvest technologies of temperature management, an array of others have been developed including various physical (heat, irradiation and edible coatings), chemical (antimicrobials, antioxidants and anti-browning) and gaseous treatments. This article examines the current status on postharvest treatments of fresh produce and emerging technologies, such as plasma and ozone, that can be used to maintain quality, reduce losses and waste of fresh produce. It also highlights further research needed to increase our understanding of the dynamic response of fresh produce to various postharvest treatments.
Paper 20: Solid Lubricants (1967)

This paper describes a research investigation encompassing a study of the combination of lubricant materials, bearings, and design criteria for the long-term operation of mechanical systems with self-contained non-fluid lubricants. The feasibility of providing an oil-free lubricated internal-combustion engine was established.
Robotic Goal-Based Semi-Autonomous Algorithms Improve Remote Operator Performance (2010)

The focus of this research was to determine if reliable goal-based semi-autonomous algorithms are able to improve remote operator performance or not. Two semi-autonomous algorithms were examined: visual servoing and visual dead reckoning. Visual servoing uses computer vision techniques to generate movement commands while using internal properties of the camera combined with sensor data that tell the robot its current position based on its previous position. This research shows that the semi-autonomous algorithms developed increased performance in a measurable way. An analysis of tracking algorithms for visual servoing was conducted and tracking algorithms were enhanced to make them as robust as possible. The developed algorithms were implemented on a currently fielded military robot and a human-in-the-loop experiment was conducted to measure performance.
The Writings of Sam Houston, 1813-1863. Edited by Amelia W. Williams and Eugene C. Barker. Volume VII, November, 1824-March, 1860. (Austin: University of Texas Press, 1942. xvi + 567 pp. $21.00 per set of eight vols.) (1943)

Journal Article The Writings of Sam Houston, 1813–1863. Edited by Amelia W. Williams and Eugene C. Barker. Volume VII, November, 1824–March, 1860. (Austin: University of Texas Press, 1942. xvi + 567 pp. $21.00 per set of eight vols.) Get access George L. Anderson George L. Anderson Colorado College Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 30, Issue 2, September 1943, Page 293, https://doi.org/10.1093/jahist/30.2.293 Published: 01 September 1943