gebhart/patrepeval huggingface dataset:
Overview of the Spinal Cord Injury – Quality of Life (SCI-QOL) measurement system (2015)

The SCI-QOL measurement system consists of psychometrically sound measures for individuals with SCI. The manuscripts in this special issue provide evidence of the reliability and initial validity of this measurement system. The SCI-QOL also links to other measures designed for a general medical population.
<title>Johns Hopkins adaptive optics coronagraph</title> (1991)

The Johns Hopkins University is developing a stellar coronagraph which will use adaptive optics to achieve nearly diffraction-limited imaging at optical wavelengths with 1-2 meter class telescopes. The first phase of development, the incorporation of an image motion compensation system into the coronagraph, is complete. Performance tests have resulted in a factor of 2 gain in image resolution, corresponding to the maximum gain predicted by theory. The next phase of development involves the construction of an electrostatically deformable membrane mirror and a wavefront curvature sensor for the removal of higher order aberrations. A membrane mirror with 91 actuators has been built for laboratory testing. Integration of the adaptive mirrors, high speed wavefront sensor, and control processor is forthcoming.
Gaze-X: Adaptive affective multimodal interface for single-user office scenarios (2006)

Abstract. This paper describes an intelligent system that we developed to support affective multimodal human-computer interaction (AMM-HCI) where the user’s actions and emotions are modeled and then used to adapt the interaction and support the user in his or her activity. The proposed system, which we named Gaze-X, is based on sensing and interpretation of the human part of the computer’s context, known as W5+ (who, where, what, when, why, how). It integrates a number of natural human communicative modalities including speech, eye gaze direction, face and facial expression, and a number of standard HCI modalities like keystrokes, mouse movements, and active software identification, which, in turn, are fed into processes that provide decision making and adapt the HCI to support the user in his or her activity according to his or her preferences. A usability study conducted in an office scenario with a number of users indicates that Gaze-X is perceived as effective, easy to use, useful, and affectively qualitative.
The Preparation of Some Piperidine Derivatives by the Mannich Reaction (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Some Piperidine Derivatives by the Mannich ReactionC. R. Noller and V. BaliahCite this: J. Am. Chem. Soc. 1948, 70, 11, 3853–3855Publication Date (Print):November 1, 1948Publication History Published online1 May 2002Published inissue 1 November 1948https://pubs.acs.org/doi/10.1021/ja01191a092https://doi.org/10.1021/ja01191a092research-articleACS PublicationsRequest reuse permissionsArticle Views1248Altmetric-Citations210LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direction of Arrival Estimation in Time Modulated Linear Arrays With Unidirectional Phase Center Motion (2010)

A novel approach for estimating the direction of arrivals (DOAs) in time modulated linear arrays (TMLAs) with unidirectional phase center motion (UPCM) scheme is proposed in this paper. Based on the fact that the main beams of the patterns at different sidebands can be directed at different directions, the corresponding received signals can be used to compose a received data space. Thus, the spatial locations of the far-field sources can be estimated by using multiple signal classification (MUSIC) algorithm. Simulation results of the DOA estimation in an 8-element TMLA with the UPCM scheme validate the proposed approach, where the performance such as the accuracy and resolution of the DOA estimation is obtained through Monte-Carlo simulations. As compared to the DOA estimation based on conventional uniform linear arrays (ULAs), a much better resolution performance is obtained.
A sample injection port for the gas-liquid chromatographic analysis of irradiated organic compounds (1967)

A sample injection port specially suited for the gas-liquid chromatographic analysis of irradiated organic compounds is described. The non volatile portion of the injected sample is retained in the evaporation chamber while other volatile components pass over into the chromatographic column. After analysis the evaporation chamber could be easily opened, cleaned and then re-covered to be ready for the subsequent analysis. Long term use of the reported device showed it to be satisfactory in use and that there were no bad effects on peak shapes or on the quantitative analysis of samples.
Central role of the respiratory syncytial virus matrix protein in infection (2006)

Respiratory syncytial virus is the major respiratory pathogen of infants and children worldwide, with no effective treatment or vaccine available. Steady progress has been made in understanding the respiratory syncytial virus life cycle and the consequences of infection, but many areas of respiratory syncytial virus biology remain poorly understood, including the role of subcellular localisation of respiratory syncytial virus gene products such as the matrix protein in the infected host cell. The matrix protein plays a central role in viral assembly and, intriguingly, has been observed to traffic into and out of the nucleus at specific times during the respiratory syncytial virus infectious cycle. Further, the matrix protein has been shown to be able to inhibit transcription, which may be a key to respiratory syncytial virus pathogenesis. This review will focus on the role of the matrix protein in respiratory syncytial virus infection and what is known of its nucleocytoplasmic trafficking, the understanding of which may lead to new therapeutic approaches to combat respiratory syncytial virus, and/or vaccine development.
Preparation and properties of glycerol‐based double‐ or triple‐chain surfactants with two hydrophilic ionic groups (1992)

A novel series of glycerol‐based double‐ or triple‐chain surfactants with two sulfonate, two sulfate or two carboxylate groups was conveniently prepared by reactions of 1‐ O ‐alkylglycerol diglycidyl ethers with long‐chain fatty alcohols, and followed by reactions with propanesultone, chlorosulfonic acid or bromoacetic acid, respectively. The sulfate and carboxylate types of compounds have higher water solubilities than the corresponding sulfonate type of compound bearing the same lipophilic group. The triple‐chain surfactants show excellent surface‐active properties, such as micelle forming and ability to lower surface tension, compared not only with the corresponding single‐chain anionic surfactants, but also with the corresponding double‐chain surfactants. The effect of the difference in head groups of these compounds on surface‐active properties is described. Foaming properties, wetting ability and lime‐soap dispersing requirement are also discussed.
Structure and Expression of an Adhesive Protein–like Molecule of Mosquito Invasive-stage Malarial Parasite (1999)

Invasion of the malarial parasite into a vector mosquito begins when the motile ookinete transverses the gut epithelium. Adhesive proteins that may mediate this invasive process have not been identified to date. We found that a molecule with an adhesive protein-like structure was expressed in the ookinete of Plasmodium berghei. This protein is structurally homologous to circumsporozoite protein and thrombospondin-related adhesive protein (TRAP)-related protein, CTRP, of Plasmodium falciparum. We named it P. berghei CTRP (PbCTRP) and report here its structure and manner of expression. PbCTRP has six integrin I region-like domains and seven thrombospondin-like domains in its putative extracellular region. This structure is similar to that of CTRP and TRAPs of malaria sporozoite. The putative transmembrane and cytoplasmic regions of PbCTRP, CTRP, and TRAP also have conserved amino acid sequences. PbCTRP is produced at least 10 h after fertilization when zygotes begin transformation to ookinetes. In the mature ookinete, PbCTRP is located mainly in the anterior cytoplasm. The staining pattern was also similar to TRAP in the sporozoite. We suggest that PbCTRP may play a role in ookinete invasive motility and belongs to a protein family together with TRAP and other structurally related proteins of apicomplexan parasites.
The Stability of the Secondary Lithium Electrode in Tetrahydrofuran‐Based Electrolytes (1978)

The stability of tetrahydrofuran (THF)‐based electrolytes toward bulk and electroplated Li has been assessed. Those electrolytes incorporating were least reactive to Li at elevated temperature and gave the best cycling efficiencies. These efficiencies could be further improved by aging the electrolyte at 71°C and by the addition of or . Conversely, degraded the performance of the secondary Li electrode. Small quantities of Na+ and the variation of inert metal substrate had little, if any, effect on cycling efficiencies. Preelectrolyzing the electrolyte improved the cycling characteristics initially, but lengthy preelectrolysis resulted in electrolyte degradation. A recontact phenomenon, whereby previously isolated Li is recouped in subsequent cycles, was noted. The intervention of films is proposed to account for these observations.
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype (2018)

Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that macrophages are the dominant leukocyte population both in human PDAC stroma and autochthonous models, with an important functional contribution to the squamous subtype of human PDAC. We targeted macrophages in a genetic PDAC model using AZD7507, a potent selective inhibitor of CSF1R. AZD7507 caused shrinkage of established tumors and increased mouse survival in this difficult-to-treat model. Malignant cell proliferation diminished, with increased cell death and an enhanced T cell immune response. Loss of macrophages rewired other features of the TME, with global changes in gene expression akin to switching PDAC subtypes. These changes were markedly different to those elicited when neutrophils were targeted via CXCR2. These results suggest targeting the myeloid cell axis may be particularly efficacious in PDAC, especially with CSF1R inhibitors.
Cell cycle regulation of the p34cdc2 inhibitory kinases. (1994)

In cells of higher eukaryotic organisms the activity of the p34cdc2/cyclin B complex is inhibited by phosphorylation of p34cdc2 at two sites within its amino-terminus (threonine 14 and tyrosine 15). In this study, the cell cycle regulation of the kinases responsible for phosphorylating p34cdc2 on Thr14 and Tyr15 was examined in extracts prepared from both HeLa cells and Xenopus eggs. Both Thr14- and Tyr15- specific kinase activities were regulated in a cell cycle-dependent manner. The kinase activities were high throughout interphase and diminished coincident with entry of cells into mitosis. In HeLa cells delayed in G2 by the DNA-binding dye Hoechst 33342, Thr14- and Tyr15-specific kinase activities remained high, suggesting that a decrease in Thr14- and Tyr15- kinase activities may be required for entry of cells into mitosis. Similar cell cycle regulation was observed for the Thr14/Tyr15 kinase(s) in Xenopus egg extracts. These results indicate that activation of CDC2 and entry of cells into mitosis is not triggered solely by activation of the Cdc25 phosphatase but by the balance between Thr14/Tyr15 kinase and phosphatase activities. Finally, we have detected two activities capable of phosphorylating p34cdc2 on Thr14 and/or Tyr15 in interphase extracts prepared from Xenopus eggs. An activity capable of phosphorylating Tyr15 remained soluble after ultracentrifugation of interphase extracts whereas a second activity capable of phosphorylating both Thr14 and Tyr15 pelleted. The pelleted fraction contained activities that were detergent extractable and that phosphorylated p34cdc2 on both Thr14 and Tyr15. The Thr14- and Tyr15-specific kinase activities co-purified through three successive chromatographic steps indicating the presence of a dual-specificity protein kinase capable of acting on p34cdc2.
Patterns for Enterprise Mashups in B2B Collaborations to Foster Lightweight Composition and End User Development (2009)

The huge demand for situational and ad-hoc applications desired by the mass of business end users cannot be fully implemented by IT departments. New approaches that allow for end user development (EUD) are needed to overcome this ldquolong-tailrdquo dilemma. More specifically, most existing approaches insufficiently support EUD for infrequent, situational, and ad-hoc B2B collaborations. Enterprise mashup and lightweight composition approaches and tools are promising solutions to unleash the huge potential of integrating the mass of users into development. Within the current research project FAST, a Web based mashup/Gadget development tool is in development that allows for different options to realize B2B collaborations via mashups. In this work, five patterns for the development of enterprise mashups are identified, characterized, and evaluated with focus on their adequacy for B2B collaborations.
Some complexity results for the Traveling Salesman Problem (1976)

It is shown that, unless P=NP, local search algorithms for the Traveling Salesman Problem having polynomial time complexity per iteration will generate solutions arbitrarily far from the optimal. The Traveling Salesman Problem is also shown to be NP-Complete even if its instances are restricted to be realizable by a set of points on the Euclidean plane.
Prevalence of Mycobacterium lentiflavum in cystic fibrosis patients, France (2015)

M. lentiflavum was the third most common mycobacteria isolated in cystic fibrosis patients, particularly in six male patients. M. lentiflavum outbreaks are emerging particularly in cystic fibrosis patients.
A differential response element for the homeotics at the Antennapedia P1 promoter of Drosophila. (1994)

Homeotic genes encode DNA-binding transcription factors that specify the identity of a segment or segments in particular body regions of Drosophila. The developmental specificity of these proteins results from their differential regulation of various target genes. This specificity could be achieved by use of different regulatory elements by the homeoproteins or by use of the same elements in different ways. The Ultrabithorax (UBX), abdominal-A (ABD-A), and Antennapedia (ANTP) homeoproteins differentially regulate the Antennapedia P1 promoter in a cell culture cotransfection assay: UBX and ABD-A repress, whereas ANTP activates P1. Either of two regions of P1 can confer this pattern of differential regulation. One of the regions lies downstream and contains homeoprotein-binding sites flanking a 37-bp region called BetBS. ANTP protein activates transcription through the binding sites, whereas UBX and ABD-A both activate transcription through BetBS and use the flanking binding sites to prevent this effect. Thus, homeoproteins can use the same regulatory element but in very different ways. Chimeric UBX-ANTP proteins and UBX deletion derivatives demonstrate that functional specificity in P1 regulation is dictated mainly by sequences outside the homeodomain, with important determinants in the N-terminal region of the proteins.
Arrhythmia profile in acromegaly (1992)

In a controlled study, the cardiac involvement and arrhythmia profile of 32 patients with acromegaly were correlated with endocrine parameters (somatomedine C, growth hormone), clinical score and duration of the disease. Data were compared with those of 50 controls free of cardiac disease. Stress ECG, 24 h Holter monitoring and echocardiography were performed. Supraventricular premature complexes occurred no more often in acromegalics than in controls. Both prevalence and severity of ventricular arrhythmia, however, were significantly higher in patients compared to controls (P less than 0.01). 15/32 (48%) acromegalic patients had complex ventricular arrhythmias (Lown III-IV) as compared with 6/50 (12%) normal subjects (P less than 0.01). Repetitive ventricular arrhythmias (Lown IV a/b) occurred in 10/32 (31%) patients, but only in 4/50 (8%) controls (P less than 0.01). Furthermore, the frequency of ventricular premature complexes increased with duration of acromegaly (P less than 0.01). No correlation was found between the severity of ventricular arrhythmia and hormone levels. Left ventricular muscle mass was significantly increased (285 +/- 139 g, P less than 0.02) due to concentric hypertrophy. Severity of ventricular arrhythmias correlated with left ventricular mass and with clinical activity score (P less than 0.01). Thus, compared to controls, acromegalic patients show more frequent and complex ventricular arrhythmias and left ventricular hypertrophy. Duration of the disease rather than hormone levels seems to be relevant for these pathological changes.
Measuring Web Latency and Rendering Performance: Method, Tools, and Longitudinal Dataset (2019)

This paper presents Webget, a measurement tool that measures Web quality of service (QoS) metrics, including the DNS lookup time, time to first byte (TTFB), and the download time. Webget also captures Web complexity metrics, such as the number and the size of objects that make up the website. We deploy the Webget test to measure the Web performance of Google, YouTube, and Facebook from 182 SamKnows probes. Using a 3.5-year-long (January 2014-July 2017) dataset, we show that the DNS lookup time of these popular content delivery networks (CDNs) and the download time of Google have improved over time. We also show that the TTFB toward Facebook exhibits worse performance than the Google CDN. Moreover, we show that the number and the size of objects are not the only factors that affect the Web download time. We observe that these webpages perform differently across regions and service providers. We also developed a Web measurement system, Web performance and rendering (WePR) that measures the same Web QoS and complexity metrics as Webget, but it also captures the Web quality of experience metrics, such as rendering time. WePR has a distributed architecture where the component that measures the Web QoS and complexity metrics is deployed on the SamKnows probe, while the rendering time is calculated on a central server. We measured the rendering performance of four websites. We show that in 80% of the cases, the rendering time of the websites is faster than the downloading time. The source code of the WePR system and the dataset is made publicly available.
The mucosal T cell integrin α<sub>M290</sub>β7 recognizes a ligand on mucosal epithelial cell lines (1993)

The integrin alpha M290 beta 7 is expressed at high levels on mucosal T cells, particularly on those within the epithelium of the gut. We now report that a mouse T cell hybridoma, MTC-1, with similar surface expression of this molecule, adhered strongly to cells of the mouse rectal carcinoma line CMT93 and that adhesion was blocked completely by the monoclonal antibody (mAb) M290. Other mAb to the alpha M290 or beta 7 subunits had little or no inhibitory effect. M290 also inhibited adhesion of the hybridoma to cells of the mouse lung carcinomas CTM64/61 and KLN205 but had little or no effect on adhesion to seven other mouse epithelial cell lines or to the human colon carcinoma line, HT29. Intraepithelial lymphocytes (IEL) isolated from the small intestine of BALB/c mice displayed potent T cell receptor-dependent cytotoxic effector function against CMT93 in the presence of low concentrations of Phytolacca americana lectin. This cytotoxic activity also was inhibited by the M290 mAb. Treatment of CMT93 cells with tumor necrosis factor-alpha and interferon-gamma induced expression de novo of ICAM-1 and reduced the inhibitory effect of M290 in tests both for adhesion and cytotoxicity. In further experiments cytotoxic activity of IEL against the mastocytoma P815 was investigated. This target cell was considered not to possess a ligand for the integrin. In this case cytotoxic effector function was triggered by anti-CD3 mAb and, in contrast to results with CMT93, target cell lysis was increased in the presence of M290 and other antibodies to the integrin, suggesting a co-stimulatory effect. These results show that alpha M290 beta 7 recognizes a ligand on the surface of certain epithelial cell lines. Further, they provide the first clear indication that this integrin may play an important role in functional interactions between T cells and the mucosal epithelium.
Development of a Radiolabeled Monoclonal Antibody to Prostate-Specific Membrane Antigen (2007)

Despite advances in the diagnosis and therapy of prostate carcinoma, it remains a serious medical problem accounting for a large number of malignancies in men each year. Although earlier detection is now possible, many patients develop advanced metastatic disease even when there is no evidence of spread at the time of initial diagnosis and treatment. These metastatic sites could initially be controlled by hormonal therapy but ultimately become resistant and the disease enters an aggressive stage for which there is currently no satisfactory therapy. In response to this perceived need, monoclonal antibodies have been considered a direct biological modifier of the disease and a vehicle to deliver radioactive metals and other cytotoxic agents to disseminated tumor sites. J591 is a monoclonal antibody that recognizes the internal portion of PSMA, a prostatespecific membrane antigen that is regularly expressed, almost exclusively, on prostate cancer tissue. The antibody has been “humanized” to reduce immune responses to it and labeled with radioactivity. Gamma-ray-emitting labeled forms of this antibody have demonstrate a high degree of binding and β-emitting labeled forms have demostrated antitumor effects in animal models. Several of the radiolabeled forms are undergoing clinical trials in humans.