gebhart/patrepeval huggingface dataset:
Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia (1996)

The efficacy of the ginkgo biloba special extract EGb 761 in outpatients with presenile and senile primary degenerative dementia of the Alzheimer type (DAT) and multi-infarct dementia (MID) according to DSM-III-R was investigated in a prospective, randomized, double-blind, placebo-controlled, multi-center study. After a 4-week run-in period, 216 patients were included in the randomized 24-week treatment period. These received either a daily oral dose of 240 mg EGb 761 or placebo. In accordance with the recommended multi-dimensional evaluation approach, three primary variables were chosen: the Clinical Global Impressions (CGI Item 2) for psychopathological assessment, the Syndrom-Kurztest (SKT) for the assessment of the patient's attention and memory, and the Nürnberger Alters-Beobachtungsskala (NAB) for behavioral assessment of activities of daily life. Clinical efficacy was assessed by means of a responder analysis, with therapy response being defined as response in at least two of the three primary variables. The data from the 156 patients who completed the study in accordance with the study protocol were taken into account in the confirmatory analysis of valid cases. The frequency of therapy responders in the two treatment groups differed significantly in favor of EGb 761, with p < 0.005 in Fisher's Exact Test. The intent-to-treat analysis of 205 patients led to similar efficacy results. Thus, the clinical efficacy of the ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type and multi-infarct dementia was confirmed. The investigational drug was found to be well tolerated.
Using Neural Net Technology to Analyze Corporate Restructuring Announcements (2003)

It is a rare day when the Wall Street Journal does not include an announcement that a company is taking a restructuring charge. Nowadays it is often assumed that this charge is being taken for the purpose of managing earnings. The problems associated with earnings management are not limited to Wall Street but can be found throughout the world's financial markets. Ongoing developments in artificial intelligence technology hold considerable promise for helping monitor and detect financial fraud and abuse. The objective of this paper is twofold: first, to illustrate how neural nets, a branch of artificial intelligence, can be used to analyze the impact of corporate restructuring announcements on stock performance and second, to propose the need for a balanced approach using both tighter accounting standards and ex-post analysis for better control of excessive earnings management practices.
Activation of the Alternative Complement Pathway by Water-Insoluble Glucans of Streptococcus Mutans: The Relation between Their Chemical Structures and Activating Potencies (1976)

Water insoluble, sticky glucan was synthesized by reacting glucosyltransferase obtained from the sulture filtrate of cariogenic Streptococcus mutans OMZ 176 on sucrose. This glucan (OMZ 176 glucan), that consisted of the backbone chains of consecutive alpha-1, 3 glucosidic linkages (65%) and the side chain of alpha-1, 6 glucosidic bonds (35%), showed an ability to activate the alternative pathway of the complment system in human serum. Water soluble glucans synthesized from the reaction of glycosyltransferases of S. mutans strain AHT, FA-I, and Ingbritt with sucrose, that have a high content of alpha-1,6 and a low content of alpha-1, 3 glucosidic linkages, were less effective to activate the complement system. Sephadex (G-25) and Dextran (T-2,000 and T-40), that consisted exclusively of alpha-1, 6 glucosidic linkages, did not significantly activate the complement system. Controlled Smith degradation products of OMZ 176 glucan, composed of the alpha-1, 3 linked glucose backbone chain alone, lost its activity. From these results it was concluded that both backbone chain of alpha-1, 3 glucose units and branched alpha-1, 6 glucose units were essential for the OMZ 176 glucan to activate the alternative pathway of the human complement system.
Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs (2014)

The endocannabinoid system comprises the CB1 and CB2 receptors (the targets of the Cannabis sativa compound delta-9-tetrahydrocannabinol), the endogenous ligands (endocannabinoids) arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, their synthesizing machinery and membrane transport system, and the hydrolyzing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. The endocannabinoids may act on demand to confer protection against aversive stimuli, which suggests that increasing their brain levels may represent an approach for treatment of anxiety-related disorders. Thus, this article reviews the profile of endocannabinoid reuptake and hydrolysis inhibitors in experimental tests predictive of anxiolytic activity. The FAAH inhibitors and the blockers of anandamide transport, in contrast to direct CB1 receptor agonists, induce anxiolytic effects at doses that do not interfere with motor activity. MAGL inhibitors also reduce anxiety-like behavior, although they are more likely to impair motor activity. Regarding their mechanisms, increasing anandamide levels induce responses mediated by the CB1 receptor and occluded by the transient receptor potential vanilloid type-1 channels, whereas the effects of increasing 2-arachidonoyl glycerol depend on both CB1 and CB2 receptors. Their neuroanatomical targets include various structures related to anxiety and fear responses. Understanding the pharmacological properties of FAAH and MAGL inhibitors may contribute toward the development of new anxiolytic interventions based on the endocannabinoid system.
Purification of T Cell Subpopulations (1991)

This unit describes a procedure for isolating T cell populations or subpopulations using the method of indirect panning. In this method, cells are selected by their capacity to bind to antibody-coated plates on the basis of particular cell-surface markers. It is superior to the antibody/complement lysis method (also presented) because the nonselected cell population can be retrieved.
Phase III Trial of Intraperitoneal Therapy With Yttrium-90–Labeled HMFG1 Murine Monoclonal Antibody in Patients With Epithelial Ovarian Cancer After a Surgically Defined Complete Remission (2006)

After a median follow-up of 3.5 years (range, 1 to 6 years), 70 patients had died in the active treatment arm compared with 61 patients in the control arm. Cox proportional hazards analysis of survival demonstrated no difference between treatment arms. In the study drug arm, 104 patients experienced relapse compared with 98 patients in the standard treatment arm. No difference in time to relapse was observed between the two study arms. Active therapy was associated with occasional grade 3 or 4 thrombocytopenia and neutropenia and grade 1 or 2 GI symptoms, abdominal discomfort, arthralgia, and myalgia. CONCLUSION A single IP administration of 90Y-muHMFG1 to patients with EOC who had a negative SLL after primary therapy did not extend survival or time to relapse.
Electro-Optical Response Analysis of a 40 Gb/s Silicon Mach-Zehnder Optical Modulator (2013)

We demonstrate a 40 Gbit/s silicon Mach-Zehnder optical modulator driven by a differential voltage of 0.36 Vpp. The energy efficiency is as low as 32.4 fJ/bit which is near the power efficiency of the ring modulator. We analyze the relationship between the electrical bandwidth and the electro-optical (EO) bandwidth based on the electrical S parameter measurement. Because of the nonlinear response, the electro-optical bandwidths in the small-signal tests are is slightly different when the modulator is biased at different transmission points. But the EO response is much different when the optical phase change is large enough to cover the nonlinear and linear regions at the same time. The nonlinearity can greatly improve the EO response in large-signal test. In our experiment, the rise/fall (20%-80%) time decreases from 13 ps to 10 ps as the driving amplitude increases from 5 V to 6 V under the same reverse bias of 3 V.
A rational surgical approach for intra-thoracic esophageal perforation. (1994)

The surgical experiences of intrathoracic esophageal perforation in 17 consecutive cases seen during the last eight years are reviewed. Using a rational approach to this critical condition, the mortality and morbidity rates were lower than before. For acute perforation in a corrosive-injured esophagus, subtotal esophagectomy by eversion stripping was an effective procedure for life saving. For acute perforation of a normal or chronic fibrotic but functional esophagus, early primary repair was usually successful for healing. For chronic esophageal perforation, usually complicated by mediastinal abscess or purulent pleural effusion, an adequate local drainage or supplemented with a newly designed, temporary diversion procedure for drainage of saliva and gastric acid was recommended.
Differential photoacoustic spectroscopic (DPAS)-based technique for PM optical absorption measurements in the presence of light absorbing gaseous species (2017)

In this study, we developed an optical monitor to measure light absorption from particulate matter (PM) at 532 nm using a differential photoacoustic absorption spectroscopic (DPAS) technique. The dual-cell system is capable of measuring the photoacoustic signals due to light absorption of total PM and gaseous samples and that of gaseous samples, separately. The resulting differential photoacoustic signal can be used to determine the light absorption purely from the PM species. This measurement method eliminates the interferences from the light-absorbing gaseous species as well as the surrounding low-frequency background acoustic noises. Photoacoustic signals of the DPAS monitor were calibrated with the NO2 gas standards, varying from 100 to 250 parts per billion (ppb). Based on an Allan analysis, a detection sensitivity (2σ) of 0.68 Mm−1 can be achieved in 100 s data acquisition. Using the Jet Burner Test Stand (JBTS) facility at the United Technologies Research Center (UTRC), we measured light absorption by the soot emissions from a representative high-temperature and high-pressure test combustor for aircraft auxiliary power units (APU). The DPAS measurement results at 532 nm, under the high gaseous NO2 conditions, were then compared to the determination of soot mass concentrations from a commercial AVL Micro Soot Sensor (MSS). An excellent linear correlation between the measurements from two instruments was observed. The mass absorption coefficient (MAC) of the soot using the two data sets was 7.4 ± 1.3 m2g−1, in good agreement with the previously reported 8.1 ± 1.7 m2g−1 and the expected value of 7.6 ± 0.6 m2g−1.Copyright © 2017 American Association for Aerosol Research
Effect of Posture on Acromiohumeral Distance With Arm Elevation in Subjects With and Without Rotator Cuff Disease Using Ultrasonography (2010)

The effect of posture on SAS, as measured by the 2-dimensional AHD using ultrasound of the posterior to middle aspect of the SAS, is small. The AHD increased with upright posture by 1.2 mm compared to normal posture, when the arm was in 45° active abduction.
Resistance of murine LTA cells to oncogene--mediated progression from tumorigenic to metastatic phenotype. (1991)

We have previously shown that expression of the H-ras oncogene alone does not induce progression of a tumorigenic but non-metastatic murine fibroblast cell line (LTA) to a metastatic phenotype. Because myc genes, alone or with ras, have been implicated at different stages of progression in other systems, we examined the ability of v-myc, alone and in combination with H-ras, to induce malignant conversion of LTA. We found no increase in either "spontaneous" (assessed after s.c. injection into nude mice) or "experimental" (assessed after i.v. injection into chick embryos) metastatic ability in spite of high levels of v-myc RNA in LTA cells transfected with v-myc alone. Serial in vivo passaging did not consistently select for either myc expression or metastatic ability. Myc transfected cells expressing high levels of myc RNA were subsequently transfected with H-ras. LTA cells expressing both oncogenes at high levels remained non-metastatic. LTA cells thus are resistant to the effects of myc and ras oncogenes (alone and in combination) on a specific stage of tumor progression, that of malignant conversion, and may offer a good model for studying mechanisms of resistance to these oncogenes.
Breaking the Dogma of the Metal‐Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity (2009)

A suitable substitute: All integrin receptors bind their ligands, which contain an aspartate residue, in the metal-ion- dependent adhesion site (MIDAS). So far all attempts to replace the carboxyl group of aspartate with other, pharmacologically favorable isosteric groups have failed. Now it has been shown that a hydroxamic acid group can replace the carboxyl group; the resulting ligand retains its high binding activity. The picture shows one such ligand in the binding site of alphavbeta3.
Phosphorylcholine Decreases Early Inflammation and Promotes the Establishment of Stable Biofilm Communities of Nontypeable <i>Haemophilus influenzae</i> Strain 86-028NP in a Chinchilla Model of Otitis Media (2006)

Nontypeable Haemophilus influenzae (NTHi) is a leading causative agent of otitis media. Much of the inflammation occurring during NTHi disease is initiated by lipooligosaccharides (LOS) on the bacterial surface. Phosphorylcholine (PCho) is added to some LOS forms in a phase-variable manner, and these PCho(+) variants predominate in vivo. Thus, we asked whether this modification confers some advantage during infection. Virulence of an otitis media isolate (NTHi strain 86-028NP) was compared with that of an isogenic PCho transferase (licD) mutant using a chinchilla (Chinchilla lanigera) model of otitis media. Animals infected with NTHi 86-028NP licD demonstrated increased early inflammation and a delayed increase in bacterial counts compared to animals infected with NTHi 86-028NP. LOS purified from chinchilla-passed NTHi 86-028NP had increased PCho content compared to LOS purified from the inoculum. Both strains were recovered from middle ear fluids as long as 14 days postinfection. Biofilms were macroscopically visible in the middle ears of euthanized animals infected with NTHi 86-028NP 7 days and 14 days postchallenge. Conversely, less dense biofilms were observed in animals infected with NTHi 86-028NP licD 7 days postinfection, and none of the animals infected with NTHi 86-028NP licD had a visible biofilm by 14 days. Fluorescent antibody staining revealed PCho(+) variants within biofilms, similar to our prior results with tissue culture cells in vitro (S. L. West-Barnette, A. Rockel, and W. E. Swords, Infect. Immun. 74:1828-1836, 2006). Animals coinfected with equal proportions of both strains had equal persistence of each strain and somewhat greater severity of disease. We thus conclude that PCho promotes NTHi infection and persistence by reducing the host inflammatory response and by promoting formation of stable biofilm communities.
Children's Oncology Group's 2013 blueprint for research: Neuroblastoma (2012)

Estimated 5-year survival rates for patients with non-high-risk and high-risk neuroblastoma are 90% and 50%, respectively. Recent clinical trials have shown excellent outcomes with reduced therapy for non-high-risk disease. For patients with high-risk neuroblastoma treated with chemoradiotherapy, surgery, and stem cell transplantation, the addition of anti-disialoganglioside (GD2) immunotherapy plus cytokines improves survival. Upcoming trials will study the incorporation of targeted radionuclide therapy prior to myeloablative chemotherapy into high-risk treatment. Phase 2 trials will investigate druggable target(s) including mTOR inhibition and GD2-directed therapy in combination with chemotherapy for patients with recurrent neuroblastoma, and ALK inhibition for those with ALK-aberrant tumors.
Effects of oral administration of some herbal extracts on foodconsumption and blood glucose levels in normal andstreptozotocin-treated diabetic rats (2006)

Previous studies in our laboratories suggest that oral administration of some herbal extracts reduce blood glucose concentrations in rats, possibly by interfering with food consumption and/or gastrointestinal absorption of food. Accordingly, we monitored the amounts of food consumed and body weights in separate groups of nondiabetic and streptozotocin-treated diabetic rats, orally treated with some plant extracts (20 mg 100 g -1 body weight) daily for 5 weeks. Control animals were administered the vehicle, citrate buffer (0.1 ml 100 g -1 body weight). Separate groups of rats administered allopathic hypoglycemic drugs metformin (50 mg 100 g -1 body weight) or glibenclamide (5 microg 100 g -1 body weight) acted as positive control animals. After 5 weeks, blood glucose concentrations were reduced in all the groups. Tapinanthus nyasicus leaf, Ficus thoningii bark, Solanum incanum fruit, and Morus alba leaf extracts decreased weekly food consumption throughout the 5-week study period. Similar results were obtained for the groups treated with metformin or glibenclamide. However, food consumption was increased by S. incanum root, Aloe chabaudii leaf, or Allium sativum bulb extracts, and this was associated with high prevalence of diarrhea. The herbal extracts and metformin did not affect serum insulin concentration in nondiabetic rats, while glibenclamide increased serum insulin concentration. In conclusion, it may be inferred that the herbal extracts examined produced hypoglycemia, probably by interfering with either food intake or gastrointestinal glucose absorption (as reported for metformin). These findings merit long-term investigation.
Peptides. IV. Racemization Suppression by the Use of Ethyl 2-Hydroximino-2-cyanoacetate and Its Amide (1973)

Abstract Racemization suppression by the addition of ethyl 2-hydroximino-2-cyanoacetate (IIIa) or 2-hydroximino-2-cyanoacetamide (IIIb), during coupling stages in peptide synthesis, was studied. The effectiveness of IIIa was compared with these of known additives by the help of Bodanszky’s test, which is a simple and accurate method for racemization detection.
Clonal expansions of CD4 <sup>+</sup> B helper T cells in autoimmune myasthenia gravis (2007)

The weakness in myasthenia gravis (MG) is mediated by T helper cell (Th)-dependent autoantibodies against neuromuscular epitopes. So far, analyzing Th phenotypes or antigen specificities has yielded very few clues to pathogenesis. Here we adopt an alternative antigen-independent approach, analyzing T cell receptor (TCR) Vbeta usage/expansions in blood from 118 MG patients. We found major expansions (>or= five standard deviations above the mean of 118 healthy, individually age- and sex-matched controls) in diverse Vbeta in 21 patients (17.6%, p<0.001) among CD4+ T cells, and in 45 patients (38.1%, p<0.001) among CD8+ T cells. In informative probands, the expanded CD4+ cells consistently showed a Th cell phenotype (CD57+CXCR5+) and expressed Th1 cytokines. Furthermore, their expression of markers for activation, lymphocyte trafficking and B cell-activating ability persisted for >or=3 years. Surprisingly, we noted a selective decline in the expansions/their CD57 positivity while the probands' MG was improving. CDR3 spectratyping suggested mono- or oligoclonal origins, which were confirmed by the prevalent TCR Vbeta CDR3 sequences of Th cells cloned from repeat bleeds. Thus, our data provide evidence for persistent clonally expanded CD4+ B helper T cell populations in the blood of MG patients. These unexpected CD4+ expansions might hold valuable clues to MG immunopathogenesis.
Multiple Legal Representation of ERISA Plans and Employers Following Allegations of Fraud and Malfeasance (1982)

8, 26, 29, 31 & 42 U.S.C.).' Section 514(a) of ERISA, 29 U.S.C. 1144(a) (1976), provides that, except for causes of action arising prior to January 1, 1975, the ERISA provisions "supersede any and all State laws insofar as they may now or hereafter relate to any employee benefit plan."ERISA section 514(cXl), 29 U.S.C. 1144(c)(1) (1976), provides that "[t]he term 'State law' includes all laws, decisions, rules, regulations, or other State action having the effect of law, of any State."State insurance, banking, or securities regulations
From Data to Insights: A Layered Storytelling Approach for Multimodal Learning Analytics (2020)

Significant progress to integrate and analyse multimodal data has been carried out in the last years. Yet, little research has tackled the challenge of visualising and supporting the sensemaking of multimodal data to inform teaching and learning. It is naïve to expect that simply by rendering multiple data streams visually, a teacher or learner will be able to make sense of them. This paper introduces an approach to unravel the complexity of multimodal data by organising it into meaningful layers that explain critical insights to teachers and students. The approach is illustrated through the design of two data storytelling prototypes in the context of nursing simulation. Two authentic studies with educators and students identified the potential of the approach to create learning analytics interfaces that communicate insights on team performance, as well as concerns in terms of accountability and automated insights discovery.
A GEO to GEO high data rate optical crosslink approach (2003)

The authors address the design of a GEO (geosynchronous Earth orbit) to GEO optical crosslink which is state-of-the-art, lightweight and low power, and which occupies little space on the satellite. The design reflects mature technologies and, as a consequence, development risk is minimized. The major components which comprise the system are discussed. The weight, power, and size for this conceptual terminal are included as are the link analyses based on the major components identified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Surface diffusion of Ge on Si(111): Experiment and simulation (1997)

Surface diffusion of Ge on Si(111) at high temperatures has been examined experimentally by second-harmonic microscopy and computationally by molecular-dynamics simulations with a Stillinger-Weber potential. Experimentally, the activation energy and preexponential factor for mass-transfer diffusion equalled 2.48\ifmmode\pm\else\textpm\fi{}0.09 eV and 6\ifmmode\times\else\texttimes\fi{}${10}^{2\ifmmode\pm\else\textpm\fi{}0.5}$ ${\mathrm{cm}}^{2}$/s, respectively. Simulational results yielded essentially the same numbers, confirming the utility of the Stillinger-Weber potential for diffusional studies. A previously developed semiempirical correlation also did fairly well. The simulations also provided estimates for the corresponding parameters for intrinsic diffusion and for the enthalpy and entropy of Ge adatom-vacancy pair formation on Si. The simulations further yielded evidence for minor contributions of atom exchange to intrinsic diffusion, as well as the complex high-temperature islanding phenomena on picosecond time scales.