gebhart/patrepeval huggingface dataset:
A Survey of Projection-Based Model Reduction Methods for Parametric Dynamical Systems (2015)

Numerical simulation of large-scale dynamical systems plays a fundamental role in studying a wide range of complex physical phenomena; however, the inherent large-scale nature of the models often leads to unmanageable demands on computational resources. Model reduction aims to reduce this computational burden by generating reduced models that are faster and cheaper to simulate, yet accurately represent the original large-scale system behavior. Model reduction of linear, nonparametric dynamical systems has reached a considerable level of maturity, as reflected by several survey papers and books. However, parametric model reduction has emerged only more recently as an important and vibrant research area, with several recent advances making a survey paper timely. Thus, this paper aims to provide a resource that draws together recent contributions in different communities to survey the state of the art in parametric model reduction methods. Parametric model reduction targets the broad class of problems for which the equations governing the system behavior depend on a set of parameters. Examples include parameterized partial differential equations and large-scale systems of parameterized ordinary differential equations. The goal of parametric model reduction is to generate low-cost but accurate models that characterize system response for different values of the parameters. This paper surveys state-of-the-art methods in projection-based parametric model reduction, describing the different approaches within each class of methods for handling parametric variation and providing a comparative discussion that lends insights to potential advantages and disadvantages in applying each of the methods. We highlight the important role played by parametric model reduction in design, control, optimization, and uncertainty quantification---settings that require repeated model evaluations over different parameter values.
Condition monitoring benefit for onshore wind turbines: sensitivity to operational parameters (2008)

The economic case for condition monitoring (CM) applied to wind turbines is currently not well quantified and the factors involved are not fully understood. In order to make more informed decisions regarding whether deployment of CM for wind turbines is economically justified, a refined set of probabilistic models capturing the processes involved are presented. Sensitivity of the model outputs with respect to variables of interest are investigated within the bounds of published data and expert opinion. The results show that the levels of benefit are dependent on a variety of factors including wind profile, typical downtime duration and wind turbine sub-component replacement cost.
An Integrated Process for Mammalian Cell Perfusion Cultivation and Product Purification Using a Dynamic Filter (2002)

In the present work, a dynamic filter was employed to develop an integrated perfusion/purification process. A recombinant CHO cell line producing a human anti-HIV IgG was employed in the experiments. In the first part of this work, the dynamic filter was fitted with conventional microfiltration membranes and tested as a new external cell retention device for perfusion cultivations. The filter was connected to a running perfusion bioreactor and operated for approximately 400 h at an average cell concentration of 10 million cells mL(-)(1), whereby cell viability remained above 90% and no problems of sterility were experienced. In the second part of this work, the dynamic filter was employed to simultaneously carry out cell separation and product purification, using membrane adsorbers containing Protein A affinity ligands. An automated system was built, which integrated the features of an automated perfusion bioreactor and of a liquid chromatography system. The IgG was continuously adsorbed onto the affinity membranes and was periodically recovered through elution cycles. After connection of the filter, the system was operated for approximately 300 h, whereby three elution cycles were carried out. No progressive increase in transmembrane pressure was observed, indicating no membrane fouling problems, and the IgG was recovered practically free of contaminants in a 14-fold concentrated form, indicating that the integrated, one-step perfusion/purification process developed during this work is a promising alternative for the production of biologicals derived from mammalian cells.
Esterification of the hydrolysis product of the herbicide dichlorfop-methyl in methanol (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEsterification of the hydrolysis product of the herbicide dichlorfop-methyl in methanolAllan E. SmithCite this: J. Agric. Food Chem. 1976, 24, 5, 1077–1078Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/jf60207a021https://doi.org/10.1021/jf60207a021research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of Hybrid Backbone Methylphosphonate DNA Heteroduplexes:  Effect of R and S Stereochemistry<sup>,</sup> (2001)

Methyl phosphonate oligonucleotides have been used as antisense and antigene agents. Substitution of a methyl group for oxygen in the phosphate ester backbone introduces a new chiral center. Significant differences in physical properties and hybridization abilities are observed between the R(p) and S(p) diastereomers. Chirally pure methylphosphonate deoxyribooligonucleotides were synthesized, and the solution structures of duplexes formed between a single strand heptanucleotide methylphosphonate, d(Cp(Me)Cp(Me)Ap(Me)Ap(Me)Ap(Me)Cp(Me)A), hybridized to a complementary octanucleotide, d(TpGpTpTpTpGpGpC), were studied by NMR spectroscopy. Stereochemistry at the methylphosphonate center for the heptanucleotide was either RpRpRpRpRpRp (R(p) stereoisomer) or RpRpRpSpRpRp (S(p) stereoisomer, although only one of the six methylphosphonate centers has the S(p) stereochemistry). The results show that the methylphosphonate strands in the heteroduplexes exhibit increased dynamics relative to the DNA strand. Substitution of one chiral center from R(p) to S(p) has a profound effect on the hybridization ability of the methylphosphonate strand. Sugars in the phosphodiester strand exhibit C(2)(') endo sugar puckering while the sugars in the methyl phosphonate strand exhibit an intermediate C(4)(') endo puckering. Bases are well stacked on each other throughout the duplex. The hybridization of the methylphosphonate strand does not perturb the structure of the complementary DNA strand in the hetero duplexes. The sugar residue 5' to the S(p) chiral center shows A-form sugar puckering, with a C(3)(')-endo conformation. Minor groove width in the R(p) stereoisomer is considerably wider, particularly at the R(p) vs S(p) site and is attributed to either steric interactions across the minor groove or poorer metal ion coordination within the minor groove.
Adhesion and Barrier Performance of Novel Barrier Adhesives Used in Multilayered High-Barrier Laminates (2012)

Abstract Flexible packaging films for highly sensitive products that are to be protected against moisture and oxygen need high barrier materials. In the food and pharmaceutical packaging industries, barrier films, which contain a single inorganic layer on top of a polymeric substrate, provide sufficient barrier. For the protection of more sensitive products, such as vacuum insulation panels, organic photovoltaic cells, or organic light emitting diodes, the barrier films are, however, not sufficient and multilayered structures of alternating inorganic and polymeric layers are required as encapsulation material to ensure sufficient product lifetime. One approach for the production of multilayered structures is the face-to-face lamination of two barrier films via lamination adhesives. Such multilayered structures are usually referred to as multilayered high-barrier laminates. Solvent-free, UV-curable, epoxy-based adhesives are promising candidates for multilayered high-barrier laminates. The adhesives best suited for multilayered high-barrier laminates are those that provide both high laminate bond strength as well as barrier performance. In this paper three different types of such adhesives are discussed in terms of their water vapor barrier and adhesion performance. The effects of the structural differences in the adhesives — chain mobility, crosslink density and surface energy — on the laminate bond strength and barrier performance are investigated. Laminate bond strength tests were performed and failure types and failure locations in the laminates were examined. The results suggest that the intrinsic barrier performance of the adhesive significantly affects the barrier performance of the laminate. On the other hand, the adhesive having the best barrier performance shows a weak adhesion performance. An appropriate adhesive was designed by adjusting the type of the flexibilizer and photoinitiator used in its formulation. This adhesive in combination with a barrier film having an enhanced surface energy shows at the same time a promising laminate bond strength as well as barrier performance.
Continuous control of liquid crystal pretilt angle from homeotropic to planar (2007)

A mixture of two polyamic acids, one having an alkyl side chain and ordinarily used for vertical liquid crystal alignment and the other without a side chain and ordinarily used for planar alignment, is deposited on two substrates and baked at high temperatures. When the resulting cell is filled with the liquid crystal pentyl cyanobiphenyl, it is found that the pretilt angle θ0 is a function of the baking temperature, and can be controlled continuously over the range of 0°⩽θ0≲90°.
An integrated life-cycle model for software maintenance (1988)

An integrated life-cycle model is presented for use in a software maintenance environment. The model represents information about the development and maintenance of software systems, emphasizing relationships between different phases of the software life cycle. It provides the basis for automated tools to assist maintenance personnel in making changes to existing software systems. The model is independent of particular specification, design, and programming languages because it represents only certain 'basic' semantic properties of software systems: control flow, data flow, and data structure. The software development processes by which one phase of the software life cycle is derived from another are represented by graph rewriting rules, which indicate how various components of a software system have been implemented. This approach permits analysis of the basic properties of a software system throughout the software life cycle. Examples are given to illustrate the integrated software life-cycle model during evolution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Hemodynamic sensing using subcutaneous photoplethysmography (2008)

Pacemakers and implantable defibrillators presently operate without access to hemodynamic information. If available, such data would allow tailoring of delivered therapy according to perfusion status, optimization of device function, and enhancement of disease monitoring and management. A candidate method for hemodynamic sensing in these devices is photoplethysmography (PPG), which uses light to noninvasively detect changes in blood volume. The present study tested the hypotheses that PPG can function in a subcutaneous location, that the acute changes in blood volume it detects are directly proportional to changes in arterial pressure, and that optimum pacing intervals identified by it are concordant with those determined by arterial pressure. Aortic pressure and PPG were simultaneously recorded in 10 dogs under general anesthesia during changes in atrioventricular (AV) delay and bursts of rapid pacing to simulate tachyarrhythmias. Direct proportionality between transient changes in pressure and PPG waveforms was tested using regression analysis. Scatter plots had a linear appearance, with correlation coefficients of 0.95 (SD 0.03) and 0.72 (SD 0.24) for rapid-pacing and AV delay protocols, respectively. The data were well described by a directly proportional relationship. Optimum AV delays estimated from the induced changes in aortic pressure and PPG waveforms were concordant. This preliminary canine study demonstrates that PPG can function subcutaneously and that it may serve as a surrogate for acute changes in arterial pressure.
Reconfigurable optical assembly of nanostructures (2016)

Arrangements of nanostructures in well-defined patterns are the basis of photonic crystals, metamaterials and holograms. Furthermore, rewritable optical materials can be achieved by dynamically manipulating nanoassemblies. Here we demonstrate a mechanism to configure plasmonic nanoparticles (NPs) in polymer media using nanosecond laser pulses. The mechanism relies on optical forces produced by the interference of laser beams, which allow NPs to migrate to lower-energy configurations. The resulting NP arrangements are stable without any external energy source, but erasable and rewritable by additional recording pulses. We demonstrate reconfigurable optical elements including multilayer Bragg diffraction gratings, volumetric photonic crystals and lenses, as well as dynamic holograms of three-dimensional virtual objects. We aim to expand the applications of optical forces, which have been mostly restricted to optical tweezers. Holographic assemblies of nanoparticles will allow a new generation of programmable composites for tunable metamaterials, data storage devices, sensors and displays.
Escala para evaluar problemas emocionales y conductuales en adolescentes (2010)

espanolEl objetivo de la presente investigacion fue determinar la estructura factorial y la confiabilidad de la escala para evaluar problemas emocionales y conductuales de Betancourt y Andrade (2010) en adolescentes de la ciudad de Poza Rica, Veracruz. Participaron 747 estudiantes de secundarias y preparatorias, 45.8% hombres y 54.2% mujeres, con una media de edad de 14.6 anos. Los resultados obtenidos corroboraron las siete de las dimensiones reportadas por Betancourt y Andrade (depresion, rompimiento de reglas, conducta agresiva, consumo de alcohol y tabaco, problemas somaticos, problemas de pensamiento y lesiones auto infringidas), asi como una confiabilidad aceptable (en un rango de 0.70 a 0.89) para todas las dimensiones. EnglishThe aim of this research was to determine the factor structure and reliability of the Betancourt and Andrade scale (2010), to assess emotional and behavioral problems in adolescents from the city of Poza Rica, Veracruz. 747 were middle and high school students, 45.8% men and 54.2% women with a mean age of 14.6 years. The results corroborated the seven dimensions reported by Betancourt and Andrade (depression, rule-breaking, aggressive behavior, alcohol and tobacco consumption, somatic problems, thinking problems and self-harm) and acceptable reliability (range from 0.70 to 0.89) for all dimensions.
Memristor-based synaptic networks and logical operations using in-situ computing (2011)

We present new computational building blocks based on memristive devices. These blocks, can be used to implement either supervised or unsupervised learning modules. This is achieved using a crosspoint architecture which is an efficient array implementation for nanoscale two-terminal mem-ristive devices. Based on these blocks and an experimentally verified SPICE macromodel for the memristor, we demonstrate that firstly, the Spike-Timing-Dependent Plasticity (STDP) can be implemented by a single memristor device and secondly, a memristor-based competitive Hebbian learning through STDP using a 1×1000 synaptic network. This is achieved by adjusting the memristor's conductance values (weights) as a function of the timing difference between presynaptic and postsynaptic spikes. These implementations have a number of shortcomings due to the memristor's characteristics such as memory decay, highly nonlinear switching behaviour as a function of applied voltage/current, and functional uniformity. These shortcomings can be addressed by utilising a mixed gates that can be used in conjunction with the analogue behaviour for biomimetic computation. The digital implementations in this paper use in-situ computational capability of the memristor.
Ribosome-inactivating proteins (2013)

Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of atomic structures and molecular mechanism has revealed these proteins to be a diverse group subdivided into two classes. RIPs have been shown to exhibit RNA N-glycosidase activity and depurinate the 28S rRNA of the eukaryotic 60S ribosomal subunit. In this review, we compare archetypal RIP family members with other potent toxins that abolish protein synthesis: the fungal ribotoxins which directly cleave the 28S rRNA and the newly discovered Burkholderia lethal factor 1 (BLF1). BLF1 presents additional challenges to the current classification system since, like the ribotoxins, it does not possess RNA N-glycosidase activity but does irreversibly inactivate ribosomes. We further discuss whether the RIP classification should be broadened to include toxins achieving irreversible ribosome inactivation with similar turnovers to RIPs, but through different enzymatic mechanisms.
CAMP: Content-Agnostic Malware Protection (2013)

Abstract---In spite of recent advances, the world wide web remains an important vector for malware installation. Approaches to evaluating potentially malicious code before execution in a browser, such as blacklisting or content-based detection are hindered by an attacker’s ability to easily change hosting domains or mutate malware binaries. On the other hand, whitelistbased approaches are challenged by the large, dynamic, and heterogeneous space of benign binaries that they must track. In practice these approaches continue to provide value for popular binaries at either extreme of maliciousness (e.g., the current large outbreak of malware, the benign binaries shipped with an OS), but bridging the gap between whitelist and blacklist detection for web malware remains a significant challenge. This paper presents CAMP, a content-agnostic malware protection system based on binary reputation that is designed to address these shortcomings. CAMP is built into the browser and determines the reputation of most downloads locally, relying on server-side reputation data only when a local decision cannot be made. This paper gives a detailed overview of CAMP and its architecture and provides an evaluation of the system through a six-month deployment in which 200 million users of Google Chrome requested between eight to ten million reputation requests a day. Our evaluation shows that CAMP exhibits accuracy close to 99 % relative to proprietary VM-based dynamic analysis, is able to process requests in less than 130 ms on average, and was able to detect approximately five million intentional malware downloads per month that were not detected by existing solutions. I.
Results of a phase I study of bispecific anti-CD19, anti-CD20 chimeric antigen receptor (CAR) modified T cells for relapsed, refractory, non-Hodgkin lymphoma. (2019)

2510 Background: Anti-CD19 CAR-T cell therapy is a breakthrough treatment (tx) for patients (pts) with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL). Despite impressive outcomes, non-response and relapse with CD19 negative disease remain challenges. Through dual B-cell antigen targeting of CD20 and CD19, with a first-in-human bispecific lentiviral CAR-T cell (LV20.19CAR), we aim to improve response rates while limiting CD19 negative relapse. Methods: Pts were treated on a Phase 1 dose escalation + expansion trial (NCT03019055) to demonstrate safety of a 41BB/CD3z LV20.19CAR T cell for adults with R/R B-cell NHL. Safety was assessed by incidence of dose limiting toxicities (DLTs) within 28 days post-infusion. Starting dose was 2.5 x 10^5 cells/kg with a target dose of 2.5 x 10^6 cells/kg. All pts received fludarabine+cyclophosphamide for lymphodepletion. Results: 11 pts have completed tx to date. 9 pts in dose escalation and 2 pts in expansion phase. Median age was 54 years (46-67) and histology included DLBCL = 5 pts, MCL = 4 pts, and CLL = 2 pts. In dose escalation, 3 pts were treated at 2.5 x 10^5 cells/kg, 3 pts at 7.5 x 10^5 cells/kg, and 3 pts at 2.5 x 10^6 cells/kg with no DLTs. As a result, 2.5 x 10^6 cells/kg was selected for expansion. In terms of safety, 6 pts developed Grade 1-2 cytokine release syndrome (CRS) and 3 pts had Grade 1-2 neurotoxicity (NTX). No patient had grade 3-4 CRS or NTX and none required ICU level care. 4 pts required 1-2 doses of tocilizumab for CRS. The day 28 overall response rate (ORR) for all pts was 82% (6/11 = complete response (CR) and 3/11 = partial response). All CR pts remain in remission, the longest > 1 year. All progressing pts underwent repeat biopsy, and all retained either CD19 or CD20 positivity. Additional pts are being enrolled in the expansion phase and updated data will be presented. Conclusions: Phase 1 results from the LV20.19 CAR T clinical trial demonstrate that infusion of 2.5 x 10^6 cells/kg is safe for further investigation with no DLTs among treated pts. Down-regulation of target antigens was not identified as a mechanism of resistance in progressing pts. With limited toxicity and encouraging ORR, dual targeted LV20.19CAR T cells merits further investigation. Clinical trial information: NCT03019055.
Adaptively constructing the query interface for meta-search engines (2001)

With the exponential growth of information on the Internet, current information integration systems have become more and more unsuitable for this "Internet age" due to the great diversity among sources. This paper presents a constraint-based query user interface model, which can be applied to the construction of dynamically generated adaptive user interfaces for meta-search engines.
Mean Diffusional Kurtosis in Patients with Glioma: Initial Results with a Fast Imaging Method in a Clinical Setting (2015)

The diffusional kurtosis imaging approach used here is considerably faster than conventional diffusional kurtosis imaging methods but yields comparable results. It can be accommodated in clinical protocols and enables exploration of the role of MK' as a biomarker in determining glioma subtypes or response evaluation.