gebhart/patrepeval huggingface dataset:
Keratinocyte Overexpression of IL-17C Promotes Psoriasiform Skin Inflammation (2013)

IL-17C is a functionally distinct member of the IL-17 family that binds IL-17 receptor E/A to promote innate defense in epithelial cells and regulate Th17 cell differentiation. We demonstrate that IL-17C (not IL-17A) is the most abundant IL-17 isoform in lesional psoriasis skin (1058 versus 8 pg/ml; p < 0.006) and localizes to keratinocytes (KCs), endothelial cells (ECs), and leukocytes. ECs stimulated with IL-17C produce increased TNF-α and KCs stimulated with IL-17C/TNF-α produce similar inflammatory gene response patterns as those elicited by IL-17A/TNF-α, including increases in IL-17C, TNF-α, IL-8, IL-1α/β, IL-1F5, IL-1F9, IL-6, IL-19, CCL20, S100A7/A8/A9, DEFB4, lipocalin 2, and peptidase inhibitor 3 (p < 0.05), indicating a positive proinflammatory feedback loop between the epidermis and ECs. Psoriasis patients treated with etanercept rapidly decrease cutaneous IL-17C levels, suggesting IL-17C/TNF-α-mediated inflammatory signaling is critical for psoriasis pathogenesis. Mice genetically engineered to overexpress IL-17C in KCs develop well-demarcated areas of erythematous, flakey involved skin adjacent to areas of normal-appearing uninvolved skin despite increased IL-17C expression in both areas (p < 0.05). Uninvolved skin displays increased angiogenesis and elevated S100A8/A9 expression (p < 0.05) but no epidermal hyperplasia, whereas involved skin exhibits robust epidermal hyperplasia, increased angiogenesis and leukocyte infiltration, and upregulated TNF-α, IL-1α/β, IL-17A/F, IL-23p19, vascular endothelial growth factor, IL-6, and CCL20 (p < 0.05), suggesting that IL-17C, when coupled with other proinflammatory signals, initiates the development of psoriasiform dermatitis. This skin phenotype was significantly improved following 8 wk of TNF-α inhibition. These findings identify a role for IL-17C in skin inflammation and suggest a pathogenic function for the elevated IL-17C observed in lesional psoriasis skin.
The TARDIS simulation (1994)

The electricity distribution industry in the UK was denationalised over four years ago. Since that time the newly formed companies have, more than ever, made strenuous efforts to demonstrate and improve the cost-effectiveness of their operations.Maintaining the working state of its widely spread electricity distribution networks remains one of their greatest financial responsibilities. A recently developed spreadsheet-based package offers the prospect of significant savings on equipment replacement.
OS/2? Presentation Manager Programming (1990)

EVOLUTION OF DOS AND OS/2 OPERATING SYSTEMS DOS OS/2 Standard Edition USING OS/2 VERSION 1.2 Operating Environments User Features in OS/2 PROGRAMMING CONCEPTS OS/2 Base System Features OS/2 Presentation Manager Functions Building an Application Message Architecture Presentation Manager Program Structure WINDOW PROGRAMMING Presentation Manager Versus Traditional Programming Window Programming Concepts Messages Dialogs User Menus GRAPHICS PROGRAMMING INTERFACE (GPI) Device Contexts Presentation Spaces Graphics Primitives Graphics Character Support Graphics Segments Transforms Storing and Printing Application Graphics ADVANCED TOPICS Application Data Transfer Subclassing Windows Placing Resources in Dynamic Link Libraries Application Debugging Tips Advanced VIO Programming Window Templates Appendices Index.
Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs) (2010)

In this review, we focus on the adult stem/progenitor cells that were initially isolated from bone marrow and first referred to as colony forming units-fibroblastic, then as marrow stromal cells and subsequently as either mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs). The current interest in MSCs and similar cells from other tissues is reflected in over 10,000 citations in PubMed at the time of this writing with 5 to 10 new publications per day. It is also reflected in over 100 registered clinical trials with MSCs or related cells (http//www.clinicaltrials.gov). As a guide to the vast literature, this review will attempt to summarize many of the publications in terms of three paradigms that have directed much of the work: an initial paradigm that the primary role of the cells was to form niches for haematopoietic stem cells (paradigm I); a second paradigm that the cells repaired tissues by engraftment and differentiation to replace injured cells (paradigm II); and the more recent paradigm that MSCs engage in cross-talk with injured tissues and thereby generate microenvironments or 'quasi-niches' that enhance the repair tissues (paradigm III).
Dynamic control and performance of a unified power flow controller for stabilizing an AC transmission system (2006)

This paper presents dynamic control and performance of a unified power flow controller (UPFC) intended for installation on a transmission system consisting of two sets of three-phase transmission lines in parallel. When no UPFC is installed, interruption of either three-phase line due to a fault reduces an active power flow to half, because the line impedance becomes double before the interruption. Installing the UPFC makes it possible to control an amount of active power flowing through the transmission system. The validity of the theoretical analysis developed in this paper is verified by experiments using a 10-kVA laboratory setup, as well as a computer simulation.
β- and γ-amino acetals containing phosphine oxide groups. Synthesis and reactions with resorcinol derivatives (2014)

New β- and γ-amino acetals containing phosphine oxide groups were synthesized by the Kabachnik-Fields reaction of β- and γ-amino acetals with paraformaldehyde and dialkylphosphine oxides. Heating of the resulting β- and γ-amino acetals with 2-methylresorcinol and pyrogallol in boiling trifluoroacetic acid afforded (dialkylphosphoryl)(ω,ω-diarylalkyl)ammonium trifluoromethanesulfonates.
Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II‐transgenic mice (2003)

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS that is associated with HLA class II molecules HLA-DR2, -DR3 and -DR4. Previously, it has been difficult to analyze the role of individual HLA molecules in disease pathogenesis due to heterogeneity of MHC genes, linkage disequilibrium, influence of non-MHC genes and contribution of environment. To overcome some of these problems, we have generated HLA-transgenic (tg) mice to investigate function and interaction of these molecules in disease pathogenesis. To investigate the role of individual HLA class II genes in immune responses to human proteolipid protein (PLP), a candidate autoantigen in MS, mice expressing HLA genes DR2, DR3, DR4 (DRB1*0401 and DRB1*0402), DQ6 and DQ8, lacking endogenous class II molecules were immunized with overlapping peptides of PLP. In all tg mice, the majority of the dominant T cell epitopes were clustered mainly to three region; amino acids 31-70, 91-120 and 178-228, of the PLP molecules. We also identified an encephalitogenic epitope PLP(91-110) that induced clinical EAE in HLA-DR3 tg mice. These tg mice had inflammatory infiltrates classically associated with EAE and showed a Th1 cytokine profile. This humanized mouse model of MS will be valuable in deciphering the role of HLA molecules and autoantigens in MS.
ABCDEF Bundle and Supportive ICU Care Practices for patients with COVID-19 infection: An international point prevalence study ~The ISIIC Study~ (2020)

Abstract Background Although the number of patients with COVID-19 infection is increasing and concerns for their long-term disabilities are increasing, there is a lack of data about the delivery of the ABCDEF-bundle and supportive care in Intensive Care Units (ICUs). The aim of this study is to investigate the implementation of the ABCDEF-bundle and supportive care provided to patients with COVID-19 infections in ICUs. Methods This was a world-wide two-day point prevalence study, on June 3 and July 1, 2020. A total of 212 ICUs in 38 countries (166 ICUs on Day 1 and 212 on Day 2) participated. Clinicians in each participating ICU completed web-based online surveys. The implementation rate for elements of the ABCDEF-bundle, other supportive ICU care measures and implementation associated structures were investigated. RESULTS Data for 262 patients was collected during the two-day study. Of patients included, 124 (47.3%) underwent mechanical ventilation (MV) and 12 (4.6%) patients were treated with extracorporeal membrane oxygenation (ECMO). The proportion of patients with implementation of each element was: Element A (regular pain assessment) 45%; B (both spontaneous awakening and breathing trials) 28%; C (regular sedation assessment) 52%; D (regular delirium assessment) 38%; E (early mobility and exercise) 47%; and F (family engagement and empowerment) 16%. The implementation of element E for patients on MV was 16% and ECMO was 17%. Supportive care, such as providing protein throughout the ICU stay (under 1.2g/kg for more than 50% of the patients) and introduction of an ICU diary (25%) was inadequate. A higher implementation rate of elements A and D were recognized in ICUs with specific protocols for ICU care and lower numbers of ICU beds exclusively for patients with COVID-19 infection. Element E was implemented at a higher rate in ICUs with more ICU beds for patients with COVID-19 infection. CONCLUSIONS This worldwide two-day point prevalence study found low implementation of the ABCDEF-bundle. Specific protocols and the number of ICU beds reserved for patients with COVID-19 infections might be key factors to deliver appropriate supportive care.Trial registration: UMIN, UMIN000040405. Registered 14 May 2020, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000046103
Effect of cytosine arabinoside on viral-specific protein synthesis in cells infected with herpes simplex virus (1975)

The relationship between viral DNA and protein synthesis during herpes simplex virus type 1 (HSV-1) replication in HeLa cells was examined. Treatment of infected cells with cytosine arabinoside (ara-C), which inhibited the synthesis of HSV-1 DNA beyond the level of detection, markedly affected the types and amounts of viral proteins made in the infected cell. Although early HSV-1 proteins were synthesized normally, there was a rapid decline in total viral protein synthesis beginning 3 to 4 h after infection. This is the time that viral DNA synthesis would normally have been initiated. ara-C also prevented the normal shift from early to late viral protein synthesis. Finally, it was shown that the effect of ara-C on late protein synthesis was dependent upon the time after infection that the drug was added. These results suggest that inhibition of progeny viral DNA synthesis by ara-C prevents the "turning on" of late HSV-1 protein synthesis but allows early translation to be "switched off."
Third harmonic shear horizontal and Rayleigh Lamb waves in weakly nonlinear plates (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yang Liu, Vamshi K. Chillara, Cliff J. Lissenden, Joseph L. Rose; Third harmonic shear horizontal and Rayleigh Lamb waves in weakly nonlinear plates. Journal of Applied Physics 21 September 2013; 114 (11): 114908. https://doi.org/10.1063/1.4821252 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioJournal of Applied Physics Search Advanced Search |Citation Search
Utilization of Polychloropropanes and Hexachloroethane (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUtilization of Polychloropropanes and HexachloroethaneE. T. McBee, H. B. Hass, T. H. Chao, Z. D. Welch, and L. E. ThomasCite this: Ind. Eng. Chem. 1941, 33, 2, 176–181Publication Date (Print):February 1, 1941Publication History Published online1 May 2002Published inissue 1 February 1941https://pubs.acs.org/doi/10.1021/ie50374a009https://doi.org/10.1021/ie50374a009research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A comparative evaluation of static analysis actionable alert identification techniques (2013)

Automated static analysis (ASA) tools can identify potential source code anomalies that could lead to field failures. Developer inspection is required to determine if an ASA alert is important enough to fix, or an actionable alert. Supplementing current ASA tools with automated identification of actionable alerts could reduce developer inspection overhead, leading to an increase in industry adoption of ASA tools. The goal of this research is to inform the selection of an actionable alert identification technique for ranking the output of automated static analysis through a comparative evaluation of actionable alert identification techniques. We investigated six actionable alert identification techniques on three subject projects. Among these six techniques, the systematic actionable alert identification (SAAI) technique reported an average accuracy of 82.5% across the three subject projects when considering both ASA tools evaluated. Check 'n' Crash reported an average accuracy of 85.8% for the single ASA tool evaluated. The other actionable alert identification techniques had average accuracies ranging from 42.2%-78.2%.
Worldwide Buzz: Planetary-Scale Views on an Instant-Messaging Network (2007)

We present a study of anonymized data capturing high-level communication activities within the Microsoft Instant Messenger network. We analyze properties of the communication network defined by user interactions and demographics, as reported and as derived from one month of data collected in June 2006. The compressed dataset occupies 4.5 terabytes, composed from 1 billion conversations per day (150 gigabytes) over one month of logging. The dataset contains more than 30 billion conversations among 240 million people. We focus on analyses of high-level characteristics and patterns that emerge from the collective dynamics of 240 million people, rather than the actions and characteristics of individuals. Analyses center on numbers and durations of conversations; the content of communications was neither available nor pursued. From the data we construct a communication graph with 190 million nodes and 1.3 billion undirected edges. We find that the graph is well connected, with an effective diameter of 7.8, and is highly clustered, with a clustering coefficient decaying slowly with exponent −0.4. We also find strong influences of homophily in activities, where people with
Behaviour of rape-seed-oils under impulse voltages (2003)

This paper deals with the breakdown behaviour of vegetable rape-seed-oils under impulse conditions. The investigations were carried out in homogeneous fields of plane-plane and inhomogeneous fields of rod-plane electrode configurations using lightning impulse (1.2/50 /spl mu/s) and switching impulse (250/2500 /spl mu/s) voltages up to 600 kV. Electrode distances varied between 5 and 50 mm respectively. To get an overview concerning the electrical properties of rape-seed oils under incipient breakdown stress, both statistical and optical experiments were made. Optical investigations used strong inhomogeneous fields with point-plane electrode configurations. The results are close to experiments in insulating mineral oil. Beyond a critical field strength, positive and negative streamers occur with similarities to streamers in mineral oil. A primary and a secondary propagation mode can be distinguished. Statistical experiments reveal that from the dielectric point of view, it is in principle possible to use rape seed oils as insulating material in power transformers. High-voltage-capacitors constructed in the past sometimes used rape seed oils as dielectric and seem to support this theory.
Structure‐Function Analysis of the Soluble Glycoprotein, sGP, of Ebola Virus (2006)

In addition to the transmembrane protein, GP(1,2), the Ebola virus glycoprotein gene encodes the soluble glycoproteins sGP and Delta-peptide. Two more soluble proteins, GP(1) and GP(1,2DeltaTM), are generated from GP(1,2) as a result of disulfide-bond instability and proteolytic cleavage, respectively, and are shed from the surface of infected cells. The sGP glycoprotein is secreted as a disulfide-linked homodimer, but there have been conflicting reports on whether it is arranged in a parallel or antiparallel orientation. Off-line HPLC-MALDI-TOF MS (MS/MS) was used to identify the arrangement of all disulfide bonds and simultaneously determine site-specific information regarding N-glycosylation. Our data prove that sGP is a parallel homodimer that contains C53-C53' and C306-C306' disulfide bonds, and although there are six predicted N-linked carbohydrate sites, only five are consistently glycosylated. The disulfide bond arrangement was confirmed by using cysteine to glycine mutations at amino acid positions 53 and 306. The mutants had a reduced ability to rescue the barrier function of TNF-alpha-treated endothelial cells--a function previously reported for sGP. This indicates that these disulfide bonds are critical for the proposed anti-inflammatory function of sGP.
Knowledge based authentication requirements (2013)

Published evaluation criteria for knowledge based authentication (KBA) methods do not provide a sufficiently formed framework to use as a guideline during design and testing of KBA methods and tools. The aim of this paper is to define a set of requirements for creating a secure user authentication method based on the user's knowledge. The requirements address four issues in user authentication. The first refers to eavesdropping an authentication session and using the intercepted information in the next session. By repeating the recorded response an attacker should not be able to authenticate himself as a legitimate user. The second issue is the ability to predict an authentication challenge by analyzing previous challenges. If an attacker can record a set of challenges over a long period, he should not be able to learn the next challenge beforehand. The third issue is the guessability of correct responses to authentication challenges. In general, multiple sources of information about the user are available to an attacker. The correct response to a challenge should not be obvious from such sources. The fourth issue is the authentication server's vulnerability. By this any information system component that is used to authenticate users is meant. If an attacker manages to gain partial or complete access to the authentication server and its data, the user's digital identity should not be compromised. These for requirements are proposed as a generic checklist against which KBA methods and tools should be checked.
Cyclooctane Metathesis Catalyzed by Silica‐Supported Tungsten Pentamethyl [(SiO)W(Me)<sub>5</sub>]: Distribution of Macrocyclic Alkanes (2014)

Metathesis of cyclic alkanes catalyzed by the new surface complex [(≡SiO)W(Me)5] affords a wide distribution of cyclic and macrocyclic alkanes. The major products with the formula C(n)H(2n) are the result of either a ring contraction or ring expansion of cyclooctane leading to lower unsubstituted cyclic alkanes (5≤n≤7) and to an unprecedented distribution of unsubstituted macrocyclic alkanes (12≤n≤40), respectively, identified by GC/MS and by NMR spectroscopies.
A Cooperative Hydrogen‐Bond‐Promoted Organophotoredox Catalysis Strategy for Highly Diastereoselective, Reductive Enone Cyclization (2013)

Metal-free cooperation: The cooperative combination of Eosin Y as a photoredox catalyst with organocatalytic thiourea allows for the highly diastereoselective construction of trans-1,2-cycloalkanes and heterocycles. This new efficient, cooperative organophotoredox/organocatalysis protocol presents a valuable alternative to metal-based photoredox approaches and is the first example of combining photoredox with hydrogen-bond catalysis (see scheme). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Further results in the fast estimation of a single frequency (1994)

The author proposes a new frequency estimator for a single complex sinusoid in complex white Gaussian noise. The estimator is applicable to problems in communications requiring high speed, recursive frequency estimation. The estimator is computationally efficient yet obtains near optimum performance at moderate signal-to-noise ratios.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Applications of Density Tagging Velocimetry (2012)

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Measuring the frequency dependent polarizability of colloidal particles from dielectrophoretic collection data (2001)

In a non-uniform ac electric field, dipole forces cause polarizable particles to experience ponderomotive forces. The particle velocity is a function of the dielectric properties of the particle, the suspending medium, particle volume and the electric field gradient. Measurement of the collection rate of particles can be used to estimate their dielectric polarizability. In this work we have measured the collection rate of sub-micrometer particles collecting at the edges of a planar interdigitated electrode array. The Fokker-Planck equation was used to simulate the spatial and temporal accumulation of particles at the electrodes. The experimental data shows that the collection rate decreases with increasing frequency of the applied field, in agreement with the predicted frequency-dependent reduction in the effective polarizability of the particles. Numerical simulations are in broad agreement with experimental results.