gebhart/patrepeval huggingface dataset:
Activation of mouse peritoneal macrophages by lysophospholipids and ether derivatives of neutral lipids and phospholipids. (1987)

Cellular damage and inflammatory processes cause activation of phospholipase A in plasma membranes resulting in the production of various lysophospholipids. Treatment of mice with L-alpha-lysophosphatidylcholine, a decomposition product of phosphatidylcholine, greatly stimulates mouse peritoneal macrophages to ingest target cells via the Fc receptors. Similarly, treatment of mice with L-alpha-lysophosphatidylethanolamine and L-alpha-lysophosphatidyl-L-serine resulted in an enhanced ingestion activity of macrophages. Cancer cell membranes contain alkyl ether derivatives of phospholipids and neutral lipids. Inflamed cancer cells release decomposition products of alkyl ether phospholipids and neutral lipids, alkyl-lysophospholipids and alkylglycerols, respectively. Administration of alkyl ether analogues of lysophospholipids into mice were able to induce stimulation of macrophages for ingestion with Fc receptor preference. Two synthetic alkylglycerols, dodecylglycerol and tridecylglycerol, were tested. Dodecylglycerol induced an efficient stimulation of macrophages for Fc-mediated ingestion whereas tridecylglycerol induced a minimal level of activation. Therefore, in vivo effect of dodecylglycerol on macrophage stimulation is similar to that of lysophospholipids and their alkyl analogues. These in vivo stimulations of macrophages for Fc receptor-mediated ingestion activity were reproduced in in vitro activation of macrophages by treatment of peritoneal cells with the alkyl lipid derivatives. Among these compounds, dodecylglycerol was found to be the most potent agent for macrophage stimulation. Since macrophages are antigen-presenting cells, the degradation products of cancer cell membrane lipids may have immune potentiating capacity.
A sensitive optical micro-machined ultrasound sensor (OMUS) based on a silicon photonic ring resonator on an acoustical membrane (2015)

With the increasing use of ultrasonography, especially in medical imaging, novel fabrication techniques together with novel sensor designs are needed to meet the requirements for future applications like three-dimensional intercardiac and intravascular imaging. These applications require arrays of many small elements to selectively record the sound waves coming from a certain direction. Here we present proof of concept of an optical micro-machined ultrasound sensor (OMUS) fabricated with a semi-industrial CMOS fabrication line. The sensor is based on integrated photonics, which allows for elements with small spatial footprint. We demonstrate that the first prototype is already capable of detecting pressures of 0.4 Pa, which matches the performance of the state of the art piezo-electric transducers while having a 65 times smaller spatial footprint. The sensor is compatible with MRI due to the lack of electronical wiring. Another important benefit of the use of integrated photonics is the easy interrogation of an array of elements. Hence, in future designs only two optical fibers are needed to interrogate an entire array, which minimizes the amount of connections of smart catheters. The demonstrated OMUS has potential applications in medical ultrasound imaging, non destructive testing as well as in flow sensing.
Unfolding and retiming for high-level DSP synthesis (1991)

A method of determining the minimum unfolding factor needed to synthesize a data path for a given sample rate is presented. Minimizing the unfolding factor is important because the time complexity for scheduling and allocation increases linearly with the unfolding factor. The authors discuss the iterative algorithm which calculates the minimum unfolding factor necessary to achieve a given sample rate with and without retiming. This algorithm is utilized within the MARS (the Minnesota architecture synthesis) design system to preprocess a dataflow graph prior to resource scheduling and allocation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Restoring the Remodeled Enlarged Left Ventricle: Experimental Benefits of In Vivo Porcine Cardioreduction in the Beating Open Heart (1998)

Conceptual models have been used to assess the efficacy of cardioreduction (i.e., Batista procedure) because in vivo models were not available. This study reproduces an experimental angiographic model of heart failure by placing a large pericardial patch to sphericalize the left ventricle. Patch removal restored an elliptical normal cardiac shape. Cardioreduction was evaluated in 20 mini-pigs on cardiopulmonary bypass. Myocardial protection with a beating open method was used and cardioplegia was not used. Studies were made after an LV incision (i.e., circumflex marginal artery occlusion with the Batista incision). A large pericardial patch sphericalized the left ventricle, and LV closure by patch removal restored normal cardiac shape (ellipse). Ventricular function was evaluated by inscribing Starling curves to fill the heart systolic elastance (Ees, conductance catheter), and surface echocardiogram for fiber shortening. After defining LV function in normal hearts on bypass only, an LV incision to divide the median ramus circumflex artery was made. This ventriculotomy reduced stoke work (SW) 37% +/- 4%, but did not change elastance (Ees) or SW/end-diastolic volume (EDV) significantly. Using the LV incision function as control, patch placement reduced SW 33% +/- 4%, Ees 40% +/- 3%, and SW/EDV 44% +/- 7% and decreased fiber shortening 43% +/- 5% by echocardiogram. Patch removal restored stroke work, SW/EDV, and Ees, and echocardiograms returned to normal values after LV incision. Ventricular function after patch removal was unchanged when the beating open cardioprotective technique was used. We conclude that sphericalization of left ventricular dimensions by pericardial patch placement causes cardiac failure that is relieved by restoring the ellipsoid shape by patch removal. These findings support the value of restoration of an elliptical shape by surgical cardioreduction, when the beating open ventricle is used for myocardial protection.
Vibrations of a nonlinear dynamic beam between two stops (2009)

This work extends the model developed by Gao (1996) for the vibrations ofa nonlinear beam to the case when one of its ends is constrained to move between two reactiveor rigid stops. Contact is modeled with the normal compliance condition for the deformablestops, and with the Signorini condition for the rigid stops. The existence of weak solutions to theproblem with reactive stops is shown by using truncation and an abstract existence theorem involving pseudomonotoneoperators. The solution of the Signorini-type problem with rigid stops is obtainedby passing to the limit when the normal compliance coefficient approaches infinity. This requiresa continuity property for the beam operator similar to a continuity property for the wave operatorthat is a consequence of the so-called div-curl lemma of compensated compactness.
A Metal-Free Organic Aqueous Capacitor Using Quinonic Compounds Couple (2014)

Redox-capacitors are electrochemical energy storage devices using the electric double layer capacity and pseudo-capacity derived from redox reactions. Because of its higher energy density than conventional electric double layer capacitors, higher power density than batteries and long cycle life, redox-capacitor is a promising candidate for grid-scale stationary energy storage device. We demonstrated the aqueous redox-capacitors using inexpensive quinonic and hydroquinonic organic compounds as redox active materials, which facilitate charge/discharge by proton insertion/extraction in aqueous electrolyte. These quinonic/hydroquinonic compounds are supported in nanoporous carbon. This capacitor exhibited high energy density (＞20 Wh kg -1 ) and high power density (＞5 A g -1 ) without the degradation after 10000 charge/discharge cycles [ Sci . Rep . 4, 3591 (2014).]. In this study, we investigated the dependence of loading rate of quinonic compound to carbon materials for further enhancement of energy density. It was found that quinonic compound, which is highly loaded in carbon (>70 wt%), can be utilized by adding a slight amount of carbon with high electrical conductivity. Finally, the high energy density of approximately 30 Wh kg -1 was achieved in the metal-free organic aqueous capacitor using quinonic compounds couple.
Severe radiation therapy–related soft tissue toxicity in a patient with porphyria cutanea tarda: A literature review (2009)

Based on this and 1 other report, caution is warranted when considering radiation therapy in patients with active porphyria.
Synthesis of a quaternary bis derivative of imipramine as a novel compound with potential anti-enuretic effect (2009)

Being a quaternary ammonium, this compound is not expected to be able to cross the BBB and thus would cause fewer CNS side effects.
Antiplatelet and Antithrombotic Effects of a Novel Selective Phosphodiesterase 3 Inhibitor, NSP-513, in Mice and Rats (2000)

We investigated the effects of NSP-513, (R)-4,5-dihydro-5-methyl-6-[4-(2-propyl-3-oxo-1-cyclohexenyl)amino] phenyl-3(2H)-pyridazinone, on phosphodiesterase (PDE) isozyme activities, in vitro platelet aggregation and in vivo thrombus formation. NSP-513 selectively inhibited human platelet PDE 3 isozyme with an IC50 value of 0.039 microM. In an in vitro human platelet aggregation assay, the IC50 values (microM) of NSP-513 for platelet aggregation induced by collagen, U-46619, arachidonic acid, adenosine diphosphate (ADP), epinephrine and thrombin were 0.31, 0.25, 0.082, 0.66, 0.23 and 0.73, respectively. In a mouse pulmonary thromboembolism model, orally administered NSP-513 showed in vivo antithrombotic effects that were 320 to 470 times more potent than those of cilostazol. In a rat carotid arterial thrombosis model, intraduodenally administered NSP-513 (0.1 mg/kg), cilostazol (30 mg/kg) and aspirin (30 mg/kg) reduced thrombus formation by 75%, 66% and 48%, respectively. However, intravenously administered dipyridamole (10 mg/kg) did not significantly prevent thrombus formation. These results demonstrate that NSP-513 has the potential to prevent not only in vitro platelet aggregation but also in vivo thrombus formation and indicate that the highly selective PDE 3 inhibitory effect of NSP-513 may make this compound useful for assessing the physiological role of PDE 3.
Photo-induced antimicrobial and decontaminating agents: recent progresses in polymer and textile applications (2012)

In recent years, antimicrobial and decontaminating products and materials have drawn a lot of attention due to the outbreaks of infectious diseases in the public, as well as potential and unwanted exposure to certain hazardous chemicals in the living environment. Photo-chemistry has revealed that both inorganic photo-catalysts and organic photo-sensitizers could generate some reactive oxygen species (ROSs) on certain polymeric surfaces under light exposure and these ROS can provide antimicrobial and decontaminating functions. Thus, researchers have been trying to incorporate the photo-active agents into various polymeric substrates to prepare self-decontaminating materials for medical applications, protective clothing, etc. This paper will provide a review of the recent research progresses in the area of photo-induced functional materials, specifically antimicrobial functions and decontamination abilities of the materials.
Automatic face recognition in HDR imaging (2014)

The gaining popularity of the new High Dynamic Range (HDR) imaging systems is raising new privacy issues caused by the methods used for visualization. HDR images require tone mapping methods for an appropriate visualization on conventional and non-expensive LDR displays. These visualization methods might result in completely different visualization raising several issues on privacy intrusion. In fact, some visualization methods result in a perceptual recognition of the individuals, while others do not even show any identity. Although perceptual recognition might be possible, a natural question that can rise is how computer based recognition will perform using tone mapping generated images? In this paper, a study where automatic face recognition using sparse representation is tested with images that result from common tone mapping operators applied to HDR images. Its ability for the face identity recognition is described. Furthermore, typical LDR images are used for the face recognition training.
Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial (2008)

Artesunate can be used in the treatment of NSCLC. Artesunate combined with NP can elevate the short-term survival rate and prolong the TTP of patients with advanced NSCLC without extra side effects.
CAMP: Collection of sequences and structures of antimicrobial peptides (2013)

Antimicrobial peptides (AMPs) are gaining importance as anti-infective agents. Here we describe the updated Collection of Antimicrobial Peptide (CAMP) database, available online at http://www.camp.bicnirrh.res.in/. The 3D structures of peptides are known to influence antimicrobial activity. Although there exists databases of AMPs, information on structures of AMPs is limited in these databases. CAMP is manually curated and currently holds 6756 sequences and 682 3D structures of AMPs. Sequence and structure analysis tools have been incorporated to enhance the usefulness of the database.
Method to determine the phase dispersion of the third-order susceptibility (1991)

A new method for measuring the phase of the third-order susceptibility chi((3)) that is based on the phenomenon of polarization beats is proposed and demonstrated. As a first application, the method was employed to study the phase dispersion of chi((3)) in Cd(S, Se)-doped glasses.
Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. (2006)

Endometriosis is an ambiguous disease and its exact pathogenesis still remains elusive to clinicians and scientists. Local and systemic aberrations in immune response are associated with endometriosis. This article reviews the literature regarding various immunological factors such as cytokines, growth factors, adhesion molecules and angiogenic factors involved in the etiopathogenesis of this disease. Our review summarizes the literature regarding biomarkers, which may be reliable nonsurgical tools used in the diagnosis of endometriosis. Superior biomarkers characterized by high sensitivity, specificity and predictive value can help in the early detection and monitoring of disease progression as well as its response to therapeutic treatments critical for its management. A combination predictive model utilizing multiple biomarkers rather then individual markers alone is proposed to improve the diagnostic performance for identifying women with a high likelihood of having endometriosis. Immunomodulators and angiogenic factor blockers have a potential for endometriosis treatment and also to alleviate the pain or infertility associated with the disease. Potential new therapeutic agents include modulators, such as cytokine receptor blockers and angiogenic receptor blockers, presently used for treating endometriosis.
Increasing Adiposity (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Well-to-Well Log Correlation Using Knowledge-Based Systems and Dynamic Depth Warping (1987)

We present a novel system for well-to-welliog correlation using knowledge-based systems and dynamic depth warping techniques. This approach overcomes a major drawback in-herent in previous methods, namely the difficulty in correlating missing or discontinuous rock units. The system has three components: (1) A Dynamic Programming algorithm to cor-relate the logs and to find the minimum-cost or &quot;best &quot; match; (2) A set of &quot;rules &quot; to guide the correlation; (3) A data base that contains the logs and other relevant geologic and seismic information. The Dynamic Programming algorithm calculates the cost of correlating each point in the first well with each of the points in the second well. The resulting matrix of dissimilarity contains cost information about every possible opera-tion which matches the well logs. The cost of matching the two wells is measured by the difference in the log values. The dynamic programming approach allows correlation across geologic structures, thinning beds, and missing or discontinuous units. A path finding algorithm then traces through the matrix to define a function which maps the
Use of Short Flat Vanes for Producing Efficient Wide-Angle Two-Dimensional Subsonic Diffusers (1958)

"An investigation of the use of flat vanes in two-dimensional subsonic diffusers was made. Using optimum designs of vane installations, high pressure recoveries and steady flows were obtained for diffuser-wall divergence angles up to 42 degrees. Criteria for optimum configurations were developed which indicated that the vanes should be symmetrically arranged in the vicinity of the diffuser throat, that the vane-passage divergence angle should be approximately 7.0 degrees, and that the vanes should have a certain predictable length dependent upon the diffuser geometry" (p. 1).
Modification in Drag of Turbulent Boundary Layers Resulting from Manipulation of Large-Scale Structures (1980)

The effects of placing a parallel-plate turbulence manipulator in a boundary layer are documented through flow visualization and hot wire measurements. The boundary layer manipulator was designed to manage the large scale structures of turbulence leading to a reduction in surface drag. The differences in the turbulent structure of the boundary layer are summarized to demonstrate differences in various flow properties. The manipulator inhibited the intermittent large scale structure of the turbulent boundary layer for at least 70 boundary layer thicknesses downstream. With the removal of the large scale, the streamwise turbulence intensity levels near the wall were reduced. The downstream distribution of the skin friction was also altered by the introduction of the manipulator.
Future Treatment of Chronic Hepatitis C (2007)

The current standard therapy for chronic hepatitis C is peginterferon plus ribavirin and yields a sustained virological response rate of approximately 50% overall. Over the past 2-3 years, many new therapeutic agents directed at a number of different viral targets have entered into development for the treatment of patients with chronic hepatitis C. Many of these agents exhibit high levels of potency against the hepatitis C virus and have a rapid onset of activity. Some agents have been abandoned because of lack of efficacy or toxicity, but many others have shown promise and are undergoing further testing. Although debated, new therapies in the immediate future will most likely be used in combination with peginterferon, either alone or with ribavirin. This concise review is focused on new drugs undergoing development for the treatment of patients with chronic hepatitis C, and on drugs that have shown efficacy in preliminary investigations and progressed to Phase II or III trials. This information should allow physicians involved in the care of patients with chronic hepatitis C to provide realistic expectations of what types of drugs are progressing in clinical development, the likelihood that new treatment will include peginterferon with or without ribavirin, and when these novel therapies might become available.
SURFACE ALLOYING OF MILD STEEL BY LASER MELTING OF AN ELECTROLESS NICKEL DEPOSIT CONTAINING CHROMIUM CARBIDES (1991)

Abstract It is possible to realize surface alloys by laser melting an electroless nickel layer containing chromium carbide particles predeposited on a mild steel substrate. By this way the surface alloy is expected to have not only a high nickel content but also an important chromium content in order to improve the corrosion resistance. The presence of chromium in solid solution results from the dissolution or melting of the carbide particles. Typical laser solidification microstructures are obtained. Dendrites consist of an austenitic Fe-Ni-Cr solid solution and interdendritic regions are constituted by an eutectic mixture containing the same austenitic solid solution and complex Fe, Ni, Cr carbides and phosphides. In comparison with a surface alloy obtained by laser melting of an electroless nickel layer without carbide particles, the corrosion resistance was slightly improved in saline aqueous solutions. The limited effect was due to the fact that the final chromium content in the present experimental conditions was not as high as that initially expected.
Mesoporous Magnetic Materials Based on Rare Earth Oxides (1999)

A novel family of mesoporous oxides of rare earth metals (Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) were synthesized with specific surface areas of 253-348 m(2) g(-1) and pore diameters of 2.5-3.0 nm (see Scheme). The mesoporous solids and their surfactant mesophase precursors are paramagnetic and exhibit a magnetic anomaly due to the mesostructured atomic arrangement.