gebhart/patrepeval huggingface dataset:
Abstract LB-29: LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap (2012)

Abstract The liver kinase B1 (LKB1) tumor suppressor inhibits cell growth through its regulation of cellular metabolism and apical-basal polarity. The best understood mechanism whereby LKB1 limits cell growth is through activation of the AMP-activated-protein-kinase/mammalian-target-of-rapamycin (AMPK/mTOR) pathway to control metabolism. Since LKB1 is also required for polarized epithelial cells to resist hyperplasia it is anticipated to function through additional mechanisms. Recently, Yes-associated protein (Yap) has emerged as a transcriptional co-activator that modulates tissue homeostasis in response to cell-cell contact. Thus this study examines a possible connection between Yap and LKB1. Restoration of LKB1 expression in HeLa cells, which lack this tumor suppressor, or shRNA knockdown of LKB1 in 293T cells, demonstrated that LKB1 promotes Yap phosphorylation, nuclear exclusion, and proteasomal degradation. The ability of phosphorylation-defective Yap mutants to rescue LKB1 phenotypes, such as reduced cell proliferation and cell size, suggest that Yap inhibition contributes to LKB1 tumor suppressor function(s). Interestingly, LKB1 inhibited Yap independently of either AMPK or mTOR activation. These findings reveal a novel mechanism whereby LKB1 may restrict cancer cell growth via the inhibition of Yap. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-29. doi:1538-7445.AM2012-LB-29
Increased turnover of arterial collagen in hypertensive rats. (1978)

The turnover of total collagen in several tissues of 12-week-old normotensive and hypertensive rats was estimated by using tritium-labeled proline as a precursor. The effect of reutilization of the label was minimized by treatment with large doses of unlabeled proline subsequent to administering the radioactive imino acid. The collagen from skin, tail tendon, aorta, and mesenteric artery in normotensive animals had a half-life of about 60--70 days. In hypertensive animals the half-lives of skin and tail tendon collagen were unchanged but the half-lives of collagen in the aorta and mesenteric artery were reduced to 17 days.
Convenient synthesis of substituted furans (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient synthesis of substituted furansEverett J. Nienhouse, Robert M. Irwin, and Gary R. FinniCite this: J. Am. Chem. Soc. 1967, 89, 17, 4557–4558Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/ja00993a076https://doi.org/10.1021/ja00993a076research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic transformations of the internal structure of a moving domain wall in magnetic nanostripes (2007)

The magnetic field (or electric current) driven domain-wall motion in magnetic nanostripes is of considerable interest because it is essential to the performance of information-storage and logic devices. One of the current key problems is to understand the complex behaviors of oscillatory domain-wall motions under applied magnetic fields stronger than the so-called Walker field, beyond which the velocity of domain walls markedly drops. In a certain range just above the Walker field, the motions are not chaotic but rather periodic with different periodicities of dynamic transformations of a moving domain wall between the different types of its internal structure. In addition, three different periodicities of the dynamic transformations are calculated, which consist of different types of domain-wall structures that are transformed from one type to another. The transformation periods vary with the field strength and the nanostripe width. This phenomenon can be described by the dynamic motion of a limited number of magnetic topological solitons such as the vortex and antivortex confined in nanostripes. These results provide a considerably better understanding and details of the domain-wall motions in soft magnetic nanostripes.
Cluster-based routing scheme for Wireless Mesh Networks (2011)

Wireless Mesh Networks (WMNs) is a part of Ad-hoc network. WMNs is very emerging and fast growing technology in wireless field. WMN has many research fields and one of them is routing field. Many routing protocol has been proposed and works by researchers for WMNs but still it's requires many works in this field. Exiting routing protocol has path discovery with help of broadcast method. Due to this reason node requires many power and message collision and congestion occurs in network. Toward this direction, we proposed a cluster-based routing protocol in which all nodes in mesh network grouped into different clusters, each cluster or group has cluster head (CH). In our proposal, we use path discovery with the help of unicast method. Unicast method helps communication in a way that networks have very less congestion and data loss too.
Type II Transmembrane Serine Protease (TTSP) deregulation in cancer (2010)

The Type II transmembrane serine proteases (TTSP) are a relatively newly identified family of proteolytic enzymes that have become the subject of intense scrutiny in the field of cancer research. Advances in genome screening technology have enabled the identification of putative members and the further characterization of existing members. The TTSPs are involved in a diverse range of physiological functions and new roles continue to be discovered. A large majority of these proteases appear to play crucial roles in the development of disease, especially cancer development and progression. This review presents the current knowledge of the biological role of those TTSPs that have been identified in the development and progression of human cancers.
A New Perspective on Listeria monocytogenes Evolution (2008)

Listeria monocytogenes is a model organism for cellular microbiology and host-pathogen interaction studies and an important food-borne pathogen widespread in the environment, thus representing an attractive model to study the evolution of virulence. The phylogenetic structure of L. monocytogenes was determined by sequencing internal portions of seven housekeeping genes (3,288 nucleotides) in 360 representative isolates. Fifty-eight of the 126 disclosed sequence types were grouped into seven well-demarcated clonal complexes (clones) that comprised almost 75% of clinical isolates. Each clone had a unique or dominant serotype (4b for clones 1, 2 and 4, 1/2b for clones 3 and 5, 1/2a for clone 7, and 1/2c for clone 9), with no association of clones with clinical forms of human listeriosis. Homologous recombination was extremely limited (r/m<1 for nucleotides), implying long-term genetic stability of multilocus genotypes over time. Bayesian analysis based on 438 SNPs recovered the three previously defined lineages, plus one unclassified isolate of mixed ancestry. The phylogenetic distribution of serotypes indicated that serotype 4b evolved once from 1/2b, the likely ancestral serotype of lineage I. Serotype 1/2c derived once from 1/2a, with reference strain EGDe (1/2a) likely representing an intermediate evolutionary state. In contrast to housekeeping genes, the virulence factor internalin (InlA) evolved by localized recombination resulting in a mosaic pattern, with convergent evolution indicative of natural selection towards a truncation of InlA protein. This work provides a reference evolutionary framework for future studies on L. monocytogenes epidemiology, ecology, and virulence.
Magnetic characterization of thin bubble films (1979)

Standard procedures for evaluating magnetic bubble materials are found to yield (∼9.25 micrometer) films. Several alternative procedures are described which yield values of magnetic parameters to 1% accuracy for thick (≳3 micrometer) bubble films. Application of these new procedures to thin (&lt;3 micrometer) bubble films decreases the accuracy somewhat, but magnetic parameters are consistent within about 2%. The new procedure is described and results are presented for a number of thin films for comparison to the results achieved by the standard procedure.
Organoantimony compounds. I. Infrared spectra of some trimethyl- and triphenyl-antimony derivatives (1969)

Organoantimony compounds of the type R 3 SbX and (R 3 Sb) 2 OX, where R is methyl or phenyl, and X is a bivalent anionic group such as SeO 4 , CrO 4 , or C 2 O 4 , have been prepared. Structural characteristics of these compounds have been determined by studying their infrared spectra in the solid state between 4000 and 250 cm −1 . The spectral results indicate that in both types of compounds the anion X is coordinated to the R 3 Sb or (R 3 Sb—O—SbR 3 ) group resulting in non-ionic, five coordinate, polymeric structures.
EFFECT OF PLANT HORMONES ON ULVA (1958)

1. Bacteria-free Ulva lactuca, in sea water media enriched with vitamins, grows as atypical, short, filamentous germlings which do not develop into a foliaceous thallus. These filaments reach a few millimeters, then bleach, leaving a few islands of intensely green cells which, upon transfer to new media, produce new germlings. 2. The initiation of new germlings from these green islands and the length of the atypical filaments are increased by the combination of kinetin + indolacetic acid; adenine and indolacetic acid seem antagonistic. Conspicuous elongation of the filaments is promoted by the addition of gibberellins to the kinetin-indolacetic acid combination. 3. A normal flat blade was obtained so far only with adenine + kinetin. 4. The responses depend both on the interaction and concentrations of these morphogenetic agents: indolacetic acid is effective only in a very narrow range of concentrations and a blade is produced only with relatively high concentrations of kinetin. 5. The rhizoids of Ulva and the cells of the green islands can produce directly new germlings and are far more resistant to unfavorable conditions than the other cells of the thallus which can originate zoospores or gametes. The morphogenetic and ecological significance of the resistant cells is discussed. 6. These responses of a relatively simply organized sea weed to plant hormones link even more tightly the green algae to the higher land plants. 7. The variety of evolutionary steps toward increased morphological complexity in the algae suggests that whole organisms, because of their relative morphological simplicity, may be valuable experimental material for studying the mode of action of plant hormones.
Cochannel interference and pilot symbol assisted modulation (1993)

Pilot symbol assisted modulation (PSAM) has been shown to give good performance in Rayleigh fading and additive noise. In cellular systems, though, it is cochannel interference, more than noise, that limits the system. The paper is the first analytical investigation of the performance of PSAM in fading, interference, and noise. The investigation yields both an exact solution and an accurate but much more computationally efficient approximation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency. (1994)

8E5 is a chronically human immunodeficiency virus (HIV)-infected human T cell line, which we have previously shown to be extremely susceptible to hydrogen peroxide (H2O2)-induced apoptosis due to a HIV-associated catalase deficiency. Here we report that HIV gene expression additionally renders 8E5 cells 10-fold more sensitive than either uninfected A3.01 cells or HIV-infected but nonexpressing 8E5L cells to killing by 15-hydroperoxyeicosatetraenoic acid (15-HPETE), as well as several other hydroperoxy fatty acids. Whereas the viability of A3.01 and 8E5L cells was relatively unaffected by exposure to 10 microM 15-HPETE, similarly treated 8E5 cells underwent apoptosis, as demonstrated by morphological changes and the presence of fragmented DNA. The unique susceptibility of 8E5 cells was attributable to their inability to convert 15-HPETE to 15-hydroxy-eicosatetraenoic acid (15-HETE) owing to a marked reduction in glutathione peroxidase activity. Since oxidized lipids have been reported to accumulate in oxidatively stressed, HIV-infected individuals, a HIV-associated glutathione peroxidase deficiency may contribute to the depletion of CD4 T cells that occurs in the acquired immune deficiency syndrome (AIDS).
Electro-optical sensors overview (1998)

Over the past 30 years, infrared (IR) imaging sensors have become smaller and more sensitive. Modern IR sensors produce high-resolution, direct TV-compatible video in total darkness or inclement weather conditions.
Characterization of a liquid-xenon-jet laser-plasma extreme-ultraviolet source (2004)

A liquid-xenon-jet laser-plasma source for extreme-ultraviolet (EUV) and soft-x-ray generation has been characterized. Being a source candidate for EUV lithography (EUVL), we especially focus on parameters important for the integration of the source in EUVL systems. The deep-ultraviolet (DUV) out-of-band radiation (λ=120–400 nm) was quantified, to within a factor of two, using a flying-circus tool together with a transmission-grating spectrograph resulting in a total DUV conversion efficiency (CE) of ∼0.33%/2πsr. The size and the shape of the xenon plasma was investigated using an in-band-only EUV microscope, based on a spherical Mo/Si multilayer mirror and a charge-coupled device detector. Scalability of the source size from 20–270 μm full width at half maximum was shown. The maximum repetition-rate sustainable by the liquid-xenon-jet target was simulated by a double-pulse experiment indicating feasibility of &gt;17 kHz operation. The xenon-ion energy distribution from the plasma was determined in a time-of-flight experiment with a Faraday-cup detector showing the presence of multi-kilo-electron-volt ions. Sputtering of silicon witness plates exposed to the plasma was observed, while a xenon background of &gt;1 mbar was shown to eliminate the sputtering. It is concluded that the source has potential to meet the requirements of future EUVL systems.
Comparison of hepatitis B virus core promoter sequences in peripheral blood mononuclear cells and serum from patients with hepatitis B. (1997)

It has been reported that hepatitis B virus (HBV) DNA is present in peripheral blood mononuclear cells (PBMCs), although it is unclear whether it actually replicates there or is adsorbed from serum. HBV DNA sequences from the core promoter and precore regions were amplified from PBMCs and serum taken from 13 patients with hepatitis B infection. Analysis by single strand conformation polymorphism, direct sequencing and cloning revealed identical HBV DNA sequences in both PBMCs and serum from five patients with acute hepatitis and in five out of eight patients with chronic hepatitis. However, in the remaining three chronic hepatitis cases, HBV DNA sequences in both PBMCs and serum were different: two patients harboured HBV DNA sequences from their PBMCs with deletions/insertions in the core promoter region and one patient harboured HBV DNA sequences from their PBMCs with two nucleotide substitutions. These findings point to a possible presence of independent HBV DNA replication in PBMCs.
Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders (2009)

Among multiple structural and functional brain changes, aging is accompanied by an increase of inflammatory signaling in the nervous system as well as a dysfunction of the immune system elsewhere. Although the long-held view that aging involves neurocognitive impairment is now dismissed, aging is a major risk factor for neurodegenerative diseases such as Alzheimer;s disease, Parkinson;s disease and Huntington's disease, among others. There are many age-related changes affecting the brain, contributing both to certain declining in function and increased frailty, which could singly and collectively affect neuronal viability and vulnerability. Among those changes, both inflammatory responses in aged brains and the altered regulation of toll like receptors, which appears to be relevant for understanding susceptibility to neurodegenerative processes, are linked to pathogenic mechanisms of several diseases. Here, we review how aging and pro-inflammatory environment could modulate microglial phenotype and its reactivity and contribute to the genesis of neurodegenerative processes. Data support our idea that age-related microglial cell changes, by inducing cytotoxicity in contrast to neuroprotection, could contribute to the onset of neurodegenerative changes. This view can have important implications for the development of new therapeutic approaches.
Radiation patterns of interfacial dipole antennas (1982)

The radiation pattern of an infinitesimal electric dipole is calculated for the case where the dipole is vertically located on the plane interface of two dielectric half spaces and for the case where the dipole is lying horizontally along the interface. For the vertical case, it is found that the radiation pattern has nulls at the interface and along the dipole axis. For the horizontal case, it is found that the pattern has a null at the interface; that the pattern in the upper half space, whose index of refraction is taken to be less than that of the lower half space, has a single lobe whose maximum is normal to the interface; and that in the lower half space, in the plane normal to the interface and containing the dipole, the pattern has three lobes, whereas in the plane normal to the interface and normally bisecting the dipole, the pattern has two maxima located symmetrically about a minimum. Interpretation of these results in terms of the Cerenkov effect is given.
Self-configurable wireless systems: spectrum monitoring in a layered configuration (2003)

As wireless mobile communication becomes a necessary part of our lives, a wide range of public and private spaces are likely to house extensions of the conventional cellular system in the form of overlay systems. A layered configuration offers a practical way to maintain continuity between outdoor and indoor communication. We address the problem of coordinating RF use of different wireless communications systems sharing the same RF spectrum in a layered configuration. We propose an arrangement that relies on signal strength measurements collected during system operation. Call throughput is provided to the overlay system without diminishing the call-handling capacity of the primary system, thus resulting in a net increase in call throughput for the combined system. In the proposed arrangement, there is no need for advance planning. No regularity requirements are imposed on the grid of cells or on the RF re-use pattern. We analyze the associated statistical quality management issues.
Fast intra-beam switching scheme using common contention channels in millimeter-wave based cellular systems (2016)

Millimeter wave (mmWave) cellular system has recently been introduced as an attractive approach for 5G mobile broadband communications. In the mmWave beamforming cellular systems, the user equipment (UE) can experience frequent service disruptions due to frequent switching among a plurality of beams if the UE follows the network controlled LTE handover procedures. In this paper, we shows how the mmWave beamforming cellular system can operate and which kind of new handovers UEs can experience. And we propose UE controlled beam switching mechanism based on contention based uplink channels. In this mechanism, UEs switch the serving beam to the target beam without random access delay using the pre-acquired contention based channels.
Analysis of the monoenoic fatty acid distribution in hydrogenated vegetable oils by silver‐ion high‐performance liquid chromatography (1995)

A silver‐ion high‐performance liquid chromatography column (hexane/acetonitrile as solvent, ultraviolet detection) was used to analyze the fatty acid distribution (as fatty acid methyl esters) of a representative sample of hydrogenated oil. Fractions containing cis ‐ and trans ‐18:1 isomers were readily separated. The positional fatty acid isomers were separated by rechromatographing these fractions. The elution order and percent compositions were compared with results obtained by gas chromatography. Of the Δ8 to Δ14 trans ‐18:1 isomers, only the Δ8 and Δ9 pair could not be separated. The Δ8 and Δ9 cis ‐18:1 pair also could not be separated, and the Δ10 isomer was poorly separated from this pair. Area percents were comparable to results obtained by gas chromatography.
Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer (1993)

If the strong evidence is accepted that cancer progression is proportional to cancer volume, it was concluded that prostate cancers larger than 0.5 ml appear to correspond to the 8% of men who will be diagnosed with a clinically significant carcinoma, as derived previously. Conversely, those 80% of prostate cancers smaller than 0.5 ml probably are not likely to reach a clinically significant size in view of the long doubling time of this cancer.
Diagnosis of Interstitial Cystitis (1990)

We reviewed clinical and histological findings in 55 patients with interstitial cystitis and 21 with voiding dysfunction secondary to other pathological conditions. Of our interstitial cystitis patients 36% would fail to meet the research definition proposed at a recent National Institutes of Health workshop. Detrusor mastocytosis was present in 64% of our interstitial cystitis patients compared to 80% of the noninterstitial cystitis group. There was no statistically significant difference in mean detrusor mast cell counts between interstitial cystitis and noninterstitial cystitis patients. Biopsies of 12 patients who did meet the proposed National Institutes of Health research definition were evaluated by immunohistochemical techniques. Early results are inconclusive. These studies indicate that interstitial cystitis is a complex disease whose diagnosis presently still must be made from a symptom complex rather than from objective histological criteria, including mastocytosis or the presence of any specific immunoreactive cell.
Methylene Tetrahydrofolate Reductase (MTHFR) 677T→C Mutation and Unexplained Early Pregnancy Loss (1998)

Methylene Tetrahydrofolate Reductase (MTHFR) and Unexplained Early Fregnancy Loss 677TRC Mutation -
THE OMA/BVI BETTER VISION PROGRAM (1965)

The Vision-Ease Corporation St. Cloud, Minnesota *Read before the annual meeting of the American Academy of Optometry, Columbus, Ohio, December 15, 1965. For publication in the March, 1965, issue of the American Journal of Optometry and Archives of American Academy of Optometry. †Vice-President.