gebhart/patrepeval huggingface dataset:
Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention. (2003)

Nitric oxide (NO)-releasing aspirin (ASA), consisting of a traditional ASA molecule to which a NO-donating moiety is covalently bound, is a promising colon cancer chemopreventive agent. NO-ASA inhibits colon cancer cell growth more potently than ASA by inhibiting cell proliferation and enhancing cell killing. We examined in cultured human colon cancer cells the effect of NO-ASA on the beta-catenin/T-cell factor signaling pathway, nuclear factor-kappaB, and NO synthase 2 and on cyclooxygenase (COX) expression, all presumed to participate in colon carcinogenesis. Besides inhibiting cell growth, NO-ASA inhibited the beta-catenin/T-cell factor signaling pathway (IC(50), 1.1 microM), nuclear factor-kappaB DNA binding (IC(50), 7.5 microM), and NO synthase 2 expression (IC(50), 2 microM). Interestingly, NO-ASA induced COX-2 expression, although it had no effect on COX-1. COX-2 induction was accompanied by increased prostaglandin E(2) production. These effects occurred at NO-ASA concentrations below or near its IC(50) for cell growth (IC(50), 2-50 microM). The metabolism of NO-ASA by these cells is characterized by a rapid deacetylation step and the formation of a conjugate with glutathione. NO-ASA had no effect on intracellular cyclic GMP concentrations. We propose a model incorporating the pleiotropic effects of NO-ASA on cell signaling and postulate that collectively these effects may contribute to its strong chemopreventive effect.
Comparison of simulation and measurement results of a high-speed intersatellite optical communication system (2006)

Optical communications systems are vital to allow high speed satellite-to-satellite and satellite-to-ground-based communication links with low power consumption and low weight. To predict the performance of such systems it is essential to have an accurate simulation model which allows to predict the experimental results. We have implemented a coherent optical communications system which can be used for ultra long free-space distances. It incorporates a challenging optical phase lock loop (PLL). We also developed a simulation model for this advanced optical telecommunication system. It is shown that the experimental and numerical results obtained are in excellent agreement. By changing the parameters of the simulation model we can predict which of those parameters are most important to achieve a reliable high speed intersatellite optical link over a long free-space distance. One of the key parameters is the performance of our optical PLL. This is most important for systems which use the highly sensitive phase-shift keying (PSK) modulation format. Our developed optical PLL with a linewidth of as low as 130Hz shows excellent results both in simulation and experiments.
Detection of cerebral embolic signals in patients with systemic lupus erythematosus (2006)

Cerebral embolism may be one of the important mechanisms responsible for the high prevalence of cerebrovascular events and the neuropsychological deficits observed in patients with SLE. Although the number of MES-positive patients was small, the lack of a significant association between MES and other known risk factors for MES suggests a complex pathogenesis for the embolisation in these patients.
A PROTOTYPE COIL FOR THE SUPERCONDUCTING SEPARATED SECTOR CYCLOTRON SuSe (1984)

A project study on a superconducting separated four sector cyclotron (SuSe) for protons and heavy ions with maximum energies of 450 MeV respectively 300 MeV/u (for ions with Q/A = 0.5) and excellent beam properties is under way. The sector magnets consist of two large superconducting sector coils (sector angle ~ 50°, outer radius 2.8 m), two layers of superconducting trimcoils, cold iron pole pieces and a warm iron yoke (~ 300 tn). The maximum field will be 4.8 T. As part of a feasibility study a prototype sector coil has been built.
The Third International Conference on Active Media Technology (2004)

In the great digital era, we are witnessing many rapid scientific and technological developments in human-centered, seamless computing environments, interfaces, devices, and systems with applications ranging from business and communication to entertainment and learning. These developments are collectively best characterized as Active Media Technology (AMT), a new area of information technology and computer science that emphasizes the proactive, seamless roles of interfaces and systems as well as new media in all aspects of digital life. The first international conference on Active Media Technology (AMT01) was held in Hong Kong in 2001, and the second International Conference on Active Media Technology (AMT03) was held in Chongqing of China in May 29-31 of 2004. Following the success of AMT01 and AMT03, the third International Conference on Active Media Technology (AMT05) will be held in Kagawa, Japan in 2005.
A New Generation of Age-and Water-Resistant Reinforced Plastics (1979)

Abstract A full treatment of the six functions of the titanate coupling agent molecule is available in the literature [1]. Table 1 lists the titanates to be discussed in this paper with a convenient letter and number code, and categorizes the titanates according to their chemical functionality and structure.
Comparison of three ELISA kits for the detection of antibodies against foot-and-mouth disease virus non-structural proteins (2005)

Three foot-and-mouth disease virus non-structural protein antibody kits: CHEKIT FMD-3ABC, Ceditest FMDVNS and 3ABC-ELISA were compared. These ELISAs were performed using panel of sera collected from negative (noninfected), vaccinated with trivalent foot and mouth disease vaccine, experimentally infected cattle as well as from animals that had been vaccinated and subsequently infected. Moreover, the panel of the FAO/OIE international reference sera for the purposes of Phase XVIII exercise was tested. The Ceditest kit had a better relative specificity (99.7% for naive and 98.8% for vaccinated cattle) than the CHEKIT and 3ABC-ELISA kits (97.2 – 98.8% and 98.1 – 99.2%, respectively). A relative sensitivity of all used kits exceeded 98%, however, the Ceditest FMDV-NS kit had the higher sensitivity (99.1%) than the CHEKIT and 3ABC-ELISA (98.2%). The weak 2 O SKR 1/2000 reference serum tested within Phase XVIII collaborative study was detected only in Ceditest kit. It can be concluded that all tested kits can be a useful tool for export/import serological examination, for foot and mouth disease control programmes and especially for eradication campaigns in situation where emergency vaccination was
Purification of C60 by a simple crystallization procedure (1992)

N. Coustel, P. Bernier, R. Aznar, A. Zahab, J. Lambert and P. Lyard, J. Chem. Soc., Chem. Commun., 1992, 1402 DOI: 10.1039/C39920001402
Plasma Total Homocysteine in Hyper- and Hypothyroid Patients before and during 12 Months of Treatment (2001)

There are consistent reports demonstrating that thyroid status is an important determinant of the plasma/serum concentration of total homocysteine (tHcy) (1)(2)(3)(4)(5)(6)(7), which has been established as an independent risk factor of vascular occlusive disease (8). In previous studies, we showed that plasma tHcy was higher in hypothyroid than in hyperthyroid patients (1)(2). Prospective studies have demonstrated normalization of tHcy after thyroid hormone replacement therapy in hypothyroid patients (3)(4), and we recently observed a transient increase in tHcy during short-term iatrogenic hypothyroidism in thyroidectomized patients (5).

To our knowledge, there has been no longitudinal study on tHcy in hyper- and hypothyroid patients across normalization of their thyroid status during treatment. In the present study, we investigated such patients before and during the first 12 months of treatment.

Forty consecutive patients with hyperthyroidism and 12 with hypothyroidism were enrolled. The study protocol was approved by the ethics committee of Haukeland University Hospital, and informed consent was obtained from all participants.

The diagnosis of hyperthyroidism was based on basal serum thyrotropin (TSH) values 15 mIU/L. All hyperthyroid patients except one were diagnosed with Graves disease.

Thirty-one of the patients with hyperthyroidism were treated with carbimazole or propylthiouracil. Nine of the patients with hyperthyroidism received radioiodine treatment as primary treatment. All patients with hypothyroidism received thyroxine as the only thyroid hormone replacement therapy.

Blood specimens were collected at inclusion and 1, 6, and 12 months after initiation of treatment. Fasting EDTA-blood samples for tHcy determination were centrifuged within 30 min. The EDTA-plasma was stored at −20 °C until analysis. Plasma tHcy, serum cobalamin, folate, creatinine, and cholesterol were determined according to established methods (5)(9 …
The role of versican G3 domain in regulating breast cancer cell motility including effects on osteoblast cell growth and differentiation in vitro– evaluation towards understanding breast cancer cell bone metastasis (2012)

Versican enhances breast cancer bone metastasis not only through enhancing tumor cell mobility, invasion, and survival in bone tissues, but also by inhibiting pre-osteoblast cell growth, differentiation, which supply favorable microenvironments for tumor metastasis.
Stroke Prevention Therapy Beyond Antithrombotics: Unifying Mechanisms in Ischemic Stroke Pathogenesis and Implications for Therapy (2002)

Beyond the traditional antithrombotic agents, statin agents, angiotensin-converting enzyme inhibitors, and vitamins may prove to be important additions to our armamentarium for stroke prevention.
1‐Aryl‐4‐Silylmethyl[60]fullerenes: Synthesis, Properties, and Photovoltaic Performance (2012)

The efficient nucleophilic addition of aryl Grignard reagents (aryl=4-MeOC(6)H(4), 4-Me(2)NC(6)H(4), Ph, 4-CF(3)C(6)H(4), and thienyl) to C(60) in the presence of DMSO produced 1,2-arylhydro[60]fullerenes after acid treatment. The reactions of the anions of these arylhydro[60]fullerenes with either dimethylphenylsilylmethyl iodide or dimethyl(2-isopropoxyphenyl)silylmethyl iodide yielded the target compounds, 1-aryl-4-silylmethyl[60]fullerenes. The properties and structures of these 1-aryl-4-silylmethyl[60]fullerenes (aryl=4-MeOC(6)H(4), thienyl) were examined by electrochemical studies, X-ray crystallography, flash-photolysis time-resolved microwave-conductivity (FP-TRMC) measurements, and electron-mobility measurements by using a space-charge-limited current (SCLC) model. Organic photovoltaic devices with a polymer-based bulk heterojunction structure and small-molecule-based p-n and p-i-n heterojunction configurations were fabricated by using 1-aryl-4-silylmethyl[60]fullerenes as an electron acceptor. The most efficient device exhibited a power-conversion efficiency of 3.4% (short-circuit current density: 8.1 mA/cm(2), open-circuit voltage: 0.69 V, fill factor: 0.59).
N-Methyl-N-D-fructosyl amphotericin B methyl ester (MF-AME), a novel antifungal agent of low toxicity: monomer/micelle control over selective toxicity. (2000)

Rational chemical modification of amphotericin B (AMB) led to the synthesis of sterically hindered AMB derivatives. The selected optimal compound, N-methyl-N-D-fructosyl amphotericin B methyl ester (MF-AME) retains the broad spectrum of antifungal activity of the parent antibiotic, and exhibits a two orders of magnitude lower toxicity in vivo and in vitro against mammalian cells. Comparative studies of MF-AME and AMB comprising the determination of the spectroscopic properties of monomeric and self-associated forms of the antibiotics, the investigation of the influence of self-association on toxicity to human red blood cells, and of the antibiotic-sterol interaction were performed. On the basis of the results obtained it can be assumed that the improvement of the selective toxicity of MF-AME could in part be a consequence of the diminished concentration of water soluble oligomers in aqueous medium, and the better ability to differentiate between cholesterol and ergosterol.
Aspects of Organoselenium Chemistry (1998)

Monoselenophosphate, SePO3H3-n n-, has been chemically synthesized and characterized. It has been shown to be identical with the biological selenium donor SePX. Hydrolysis of selenophosphate is pH dependent and maximal at about pH 7. The dianion is the species which hydrolyzes fastest. The hydrolysis occurs via a dissociative monomeric metaphosphate-like transition state. Alcohols and amines are phosphorylated by monoselenophosphate. The sensitivity of detection of both 77Se and 125Te by NMR spectroscopy has been greatly increased by inverse proton detection using multiple-quantum 1H-{77Se} and 1H-{125Te} correlation spectroscopy. One- and two-dimensional HMQC spectra have been obtained for a variety of organoselenium and tellurium compounds. The signal enhancement obtained by such methods are comparable to the theoretical values.
Purification and Characterization of NF‐R2 that Regulates the Expression of the Human Multidrug Resistance (MDR1) Gene (1993)

NF-R2 is a DNA-binding protein that interacts with the MDR1 gene proximal promoter sequence. We previously reported that NF-R2 binds within the promoter's -126 and -102 regions, which contain the ATTCAGTCA motif. In the present study, we have purified NF-R2 from the nuclear extract of K562/ADM cells, a multidrug-resistant cell line derived from human myelogenous leukemia K562 cells, using sequential chromatography on Sephacryl S-300, DEAE-Sepharose, heparin-Sepharose and a DNA affinity column consisting of a repetitive synthetic ATTCAGTCA motif coupled to Sepharose. NF-R2 runs as a single protein of 75 kDa on SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis). CAT (chloramphenicol acetyltransferase) expression assay and gel mobility shift competition assay with mutated promoters revealed that the ATTCAGTCA motif is a positive regulatory element of MDR1 gene and that the motif is important for NF-R2 binding. These results suggest that NF-R2 may be involved in the positive regulation of the MDR1 gene transcription.
Efficient GPU-Based Texture Interpolation using Uniform B-Splines (2008)

This article presents uniform B-spline interpolation, completely contained on the graphics processing unit (GPU). This implies that the CPU does not need to compute any lookup tables or B-spline basis functions. The cubic interpolation can be decomposed into several linear interpolations [Sigg and Hadwiger 05], which are hard-wired on the GPU and therefore very fast. Here it is demonstrated that the cubic B-spline basis function can be evaluated in a short piece of GPU code without any conditional statements. Source code is available online.
HYBRID TECHNIQUE FOR SOFTWARE CODE CLONE DETECTION (2012)

Software Clone detection is one of the hottest research area that helps in detecting duplicate code from an applications. The research has shown that 5% to 20% of software systems can contain duplicated code that is generated by simply copying the existing program code and pasting with or without minor modifications. Cloning creates problem when a bug is found in one code segment that was copied and pasted at several locations earlier. The objective of this study is to analyze the working of hybrid clone detection technique that design and analyze a hybrid technique for detecting software clone in an application. We will combine metric approach with text base (line of code) technique for the above said reason. A model will be designed to automate the concept of clone detection.
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia (2021)

Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated the transcriptional coactivator, ENL, as a selective requirement for the survival of acute leukemia and highlighted an essential role for its chromatin reader YEATS domain. Motivated by these discoveries, we executed a screen of nearly 300,000 small molecules and identified an amido-imidazopyridine inhibitor of the ENL YEATS domain (IC<sub>50</sub> = 7 μM). Improvements to the initial screening hit were enabled by adopting and expanding upon a SuFEx-based approach to high-throughput medicinal chemistry, ultimately demonstrating that it is compatible with cell-based drug discovery. Through these efforts, we discovered SR-0813, a potent and selective ENL/AF9 YEATS domain inhibitor (IC<sub>50</sub> = 25 nM). Armed with this tool and a first-in-class ENL PROTAC, SR-1114, we detailed the biological response of AML cells to pharmacological ENL disruption for the first time. Most notably, we discovered that ENL YEATS inhibition is sufficient to selectively suppress ENL target genes, including <i>HOXA9/10</i>, <i>MYB</i>, <i>MYC</i>, and a number of other leukemia proto-oncogenes. Cumulatively, our study establishes YEATS domain inhibition as a viable approach to disrupt the pathogenic function of ENL in acute leukemia and provides the first thoroughly characterized chemical probe for the ENL YEATS domain.
Local microRNAs in peritoneal dialysis-relatedperitonitis (2019)

Infection remains a major cause of morbidity, mortality and technique failure in PD patients. Identification of peritonitis episodes and the causative organism is slow and
unreliable. The immune system has evolved to be specific for different pathogens, suggesting a pathogen specific “immune fingerprint” may be able to distinguish distinct pathogens to guide more accurate treatment decisions. microRNAs are post-transcriptional
regulators of most human genes and have roles in the majority of biological processes and pathways. They are stable, accurate and specific biomarkers in biological fluids. My work aimed to combine the immune fingerprint model with specific microRNAs in PD effluent to identify peritonitis episodes and ascertain the role of extracellular microRNAs in the acute immune response.
Approach
The microRNA profile of PD effluent was analysed in peritonitis patients with different infectious organisms to identify candidate biomarkers. The cellular source of these
microRNAs was identified, and the functional release of one microRNA (miR-223) into the extracellular space was analysed for functional stabilisation in extracellular vesicles.
Results
microRNA profiles are altered in infected compared to uninfected PD effluent, which may have diagnostic value in acute peritonitis. Four microRNAs were identified as candidate biomarkers (miR-223, miR-27a, miR-21 and miR-31), with distinct cell-specific expression patterns. Potential mRNA targets of these microRNAs were identified. miR-223 was found to be functionally stabilised in PD effluent from peritonitis patients, with a proportion likely to be incorporated into neutrophil-derived exosomes.
Conclusions
My studies prove that microRNAs are useful biomarkers of infection in PD-related peritonitis and have the potential to contribute to a pathogen-specific immune fingerprint.
Exosome-encapsulated microRNAs may have a functional role in intercellular signalling between immune cells responding to the infection and the local tissue, to help clear the
infection and resolve the inflammation.
In Search Of A Standardized Model for Institutional Repository Assessment or How Can We Compare Institutional Repositories (2008)

Assessing universities and faculty is a continuous struggle. Academic administrators must labor year after year to gather meaningful statistics for assessment exercises such as periodic institutional accreditations, program reviews, and annual funding requests. It is hard to overstate the difficulty and complexity of compiling such data. The professional literature of higher education administration contains frequent calls over the past several decades, for better ways to measure performance in colleges and universities. One way to accomplish this is through the work of research libraries and their use of institutional repositories. Developing a standardized way to assess a university's ouput through the use of digital repository metrics is one such method to assess and compare separate institutions. This paper looks at several models that could be of use in this process.
Responses to dynamic leg exercise in man as influenced by changes in muscle perfusion pressure. (1987)

The influences of induced alterations in muscle perfusion pressure on the physiological responses to rhythmic exercise in man were investigated. The experiments were carried out in healthy subjects performing leg exercise on a cycle ergometer at light to exhaustive work intensities. Increased muscle perfusion pressure was brought about by exposing the working legs of the supine subject to a subatmospheric pressure of -50 mm Hg (Lower Body Negative Pressure, LBNP), decreased perfusion pressure by instead applying a supraatmospheric pressure of 50 mm Hg (Leg Positive Pressure, LPP). In this way, the perfusion pressure in dynamically exercising large muscle groups could be altered in a controlled fashion. The influences of such manipulation of the perfusion pressure on the physiological adjustments to incremental-load exercise were studied and analysed. The main results and conclusions were as follows: (1) Exercise-induced increases in cardiac output were attenuated by LBNP, an effect caused by curtailment of stroke volume secondary to suction-induced sequestration of blood volume in capacitance vessels not affected by the action of the leg muscle pump. This situation resembles that of dynamic leg exercise in the upright body position. Thus, supine exercise with LBNP at -50 mm Hg seems to be a valid model of upright leg exercise, not only in that it increases perfusion pressure in working muscles but also by causing similar changes in the central circulation as a shift from supine to upright leg exercise. (2) Exercise-induced increases in systolic arterial pressure were markedly exaggerated by LPP, an effect attributable to increased exercise responses in both cardiac output and total peripheral resistance. The exaggerated pressor response supports the notion of a muscle chemoreflex drive in response to flow-restricted exercise tending to reduce the existing flow error. (3) Exercise-induced increases in O2 uptake and blood lactate concentration were both attenuated by LBNP and exaggerated by LPP. The changes in blood lactate levels are attributable to perfusion-pressure dependent variations in muscle blood flow, resulting in opposite changes in the share contributed by anaerobic metabolism to the energy release. Possible explanations for the fact that impaired muscle perfusion was associated with increased O2 uptake at given external work loads are discussed. (4) Exercise-induced responses of the pulmonary ventilation were attenuated by LBNP and markedly exaggerated by LPP.(ABSTRACT TRUNCATED AT 400 WORDS)