gebhart/patrepeval huggingface dataset:
Activity and Stability Studies of Verbascoside, a Novel Antioxidant, in Dermo-Cosmetic and Pharmaceutical Topical Formulations (2011)

We here report the results of our investigations carried out on verbascoside, a phenylpropanoid glycoside known for its antioxidant, anti-inflammatory and photoprotective actions. Verbascoside was obtained from Buddleia davidii meristematic cells, obtained in turn using a sustainable biotechnology platform which employs an in vitro plant cell culture technology. Verbascoside was first investigated to assess the behaviour of the active ingredient in solution or in finished preparations, in view of its potential topical use, especially in skin protection. Stability studies were performed by HPLC, and a PCL assay was adopted to determine the radical scavenging activity toward superoxide anion. The high hydrophilic character of verbascoside, suggested in a somewhat limited range of possible applications, leading us to explore its derivatization to obtain the semi-synthetic derivative VPP, an acyl derivative of verbascoside, with an improved range of applications due to its lower hydrophilic profile. Alone, VPP revealed increased antioxidant activity, both as an active ingredient and in dermocosmetic preparations. Stability studies showed a greater stability of VPP in lipophilic vehicles, whereas the parent verbascoside proved more stable in an O/W emulsions. Verbascoside was also stable in suppositories, an interesting pharmaceutical form for possible applications in treatment of inflammation of the intestinal mucosa.
Reinvestigation of 4-Thiothymidine-5′-triphosphate Synthesis (1999)

Abstract The 4-Thiothymidine-5′-triphosphate 1 (S4TTP) was known to be a substrate for polymerase, however a commercial sample of this compound failed to be incorporated into DNA. Mass spectrometry combined to alkaline phosphatase digestion and 31P-NMR showed that this sample was in fact 5′-chloro-5′-deoxy-4-thiothymidine-3′-triphosphate 2 . The desired S4TTP was synthesized by two alternate routes, was fully characterized and was shown to be incorporated in a DNA polymerase assay.
Identifying and analyzing different cancer subtypes using RNA-seq data of blood platelets (2017)

Detection and diagnosis of cancer are especially important for early prevention and effective treatments. Traditional methods of cancer detection are usually time-consuming and expensive. Liquid biopsy, a newly proposed noninvasive detection approach, can promote the accuracy and decrease the cost of detection according to a personalized expression profile. However, few studies have been performed to analyze this type of data, which can promote more effective methods for detection of different cancer subtypes. In this study, we applied some reliable machine learning algorithms to analyze data retrieved from patients who had one of six cancer subtypes (breast cancer, colorectal cancer, glioblastoma, hepatobiliary cancer, lung cancer and pancreatic cancer) as well as healthy persons. Quantitative gene expression profiles were used to encode each sample. Then, they were analyzed by the maximum relevance minimum redundancy method. Two feature lists were obtained in which genes were ranked rigorously. The incremental feature selection method was applied to the mRMR feature list to extract the optimal feature subset, which can be used in the support vector machine algorithm to determine the best performance for the detection of cancer subtypes and healthy controls. The ten-fold cross-validation for the constructed optimal classification model yielded an overall accuracy of 0.751. On the other hand, we extracted the top eighteen features (genes), including TTN, RHOH, RPS20, TRBC2, in another feature list, the MaxRel feature list, and performed a detailed analysis of them. The results indicated that these genes could be important biomarkers for discriminating different cancer subtypes and healthy controls.
Mouse S-Factors Based on Monte Carlo Simulations in the Anatomical Realistic Moby Phantom for Internal Dosimetry (2007)

It is possible to calculate S-factors that are specific for small animals, such as mice. The Moby phantom is useful as a dosimetry model because it is anatomically realistic, but still very flexible, with 35 accurately segmented regions.
Severe infections caused by Propionibacterium acnes: an underestimated pathogen in late postoperative infections. (1998)

Propionibacterium acnes belongs to the cutaneous flora of humans and is rarely considered a pathogen in human diseases. It is a frequent contaminant in blood cultures; however, in some patients it has been identified as the causative agent of life-threatening infections. Within the last years we have observed an abrupt increase in severe P. acnes infections which prompted us to study in detail the clinical and microbiological features, risk factors, and outcomes of these cases. In a retrospective review of microbiological records of 905 Propionibacterium isolates from a five-year period (1990-95), 70 were identified from 20 patients with clinical and microbiological evidence of a P. acnes infection. The clinical syndromes included endocarditis (7 patients), post-craniotomy infections (6 patients), arthritis and spondylodiscitis (4 patients), endophthalmitis (2 patients) and pansinusitis (1 patient). The predominant predisposing conditions were previous surgery preceding the infection from 2 weeks to 4 years and implantation of foreign bodies such as prosthetic heart valves, intraocular lenses and ventriculo-peritoneal shunts. Therapy consisted of intravenous antibiotics in all cases and surgical procedures to remove infected tissue in eighteen patients. The outcome was favorable in sixteen patients (80 percent) who had a complete recovery. These data confirm the pathogenic potential of P. acnes in late post-surgical infections, in particular after implantation of a foreign body, and suggest a combined therapeutic approach with intravenous antibiotics and surgical removal of the infected tissue.
Chemical Shift Standards in High-Resolution Solid-State NMR (2) 15N Nuclei (1991)

Abstract 15N NMR spectra of the shift standard compound, pure nitromethane, have been measured with high resolution by spinning the liquid sample at the magic angle. Using the precise resonance position of nitromethane, the chemical shifts of the solid second-standard materials such as ammonium salts and glycine have been measured with great precision.
DAMPAK PROGRAM RASKIN TERHADAP PEMENUHAN KEBUTUHAN POKOK RUMAH TANGGA SASARAN DI KECAMATAN KOTO SALAK DHARMASRAYA (2016)

This research aim to for description of execution of Program of Raskin, studying perception of society to Program of Raskin seen from accuracy of quality and time of Raskin, and also for description affect held of Program of Raskin to accomplishment of requirement of Fundamental Household Target in Kecamatan Koto Salak. this Type Research is descriptive research. Instrument the used is enquette sheet, guidance interview and documentation. Result of this research ofto that amount of accepted rice have according to but amount of which is determined by government less as according to amount of accepted by society, this according to responder answer counted 74,14% expressing the amount of accepted rice have according to, later then perception of society to execution of Program of Raskin seen from accuracy of time less according to, this can be seen by 81,90% expressing execution of Program of Raskin still happened delay. Hereinafter the quality of alloted Raskin less good or have rice to him it still less competent to in consumption by society. This according to responder answer counted 50% expressing the quality of Raskin less good or have rice to him still less competent to be consumed, and also affect execution of Program of Raskin to society enough assist and lighten burden expenditure of society. As a whole Program of Raskin enough assist and lighten burden expenditure of society inNagari Koto Salak dan Nagari Padukuan Kecamatan Koto Salak. Keyword: Raskin, Society, Requirement of Fundamental,Kecamatan Koto Salak
Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia (2006)

The Dana-Farber Cancer Institute (DFCI) Childhood ALL Consortium Protocol 95-01 was designed to minimize therapy-related morbidity for children with newly diagnosed ALL without compromising efficacy. Patients participated in randomized comparisons of (1) doxorubicin given with or without dexrazoxane, a cardioprotectant (high-risk patients), (2) intensive intrathecal chemotherapy and cranial radiation (standard-risk patients), and (3) Erwinia and Escherichia coli asparaginase (all patients). Between 1996 and 2000, 491 patients (aged 0-18 years) were enrolled (272 standard risk and 219 high risk). With a median of 5.7 years of follow-up, the estimated 5-year event-free survival (EFS) for all patients was 82%+/-2%. Dexrazoxane did not have a significant impact on the 5-year EFS of high-risk patients (P=.99), and there was no significant difference in outcome of standard-risk patients based on type of central nervous system (CNS) treatment (P=.26). Compared with E coli asparaginase, Erwinia asparaginase was associated with a lower incidence of toxicity (10% versus 24%), but also an inferior 5-year EFS (78%+/-4% versus 89%+/-3%, P=.01). We conclude that (1) dexrazoxane does not interfere with the antileukemic effect of doxorubicin, (2) intensive intrathecal chemotherapy is as effective as cranial radiation in preventing CNS relapse in standard-risk patients, and (3) once-weekly Erwinia is less toxic than E coli asparaginase, but also less efficacious.
Optical Design and development of Near Range Compact Lidar (2011)

There are large demands to monitor the atmosphere in the closed space (hall, factory and so on), to check vegetation remotely and to detect hazardous gases such as explosive gas and bio terror from explosion-proof distance. On the contrary, traditional lidars have blind area, it is hard to monitor the atmosphere and the gas in the near range. In this study, optical designs and concrete developments for the atmosphere monitoring and the certain gas detection in near range were accomplished. Unique optical designs are introduced and their practical setups are explained.
Linearized Discrete Charge Balance Control with Simplified Algorithm for DCM Buck Converter (2019)

In this paper, a linearized discrete charge balance (LDCB) control strategy is proposed for buck converter operating in discontinuous conduction mode (DCM). For DC-DC power converters, discrete charge balance (DCB) control is an attractive approach to improve the output voltage transient response. However, as a non-linear control strategy, the algorithm is complex, which is difficult for implementation. To reduce the complexity, this paper proposes the LDCB control strategy that is derived through linearizing conventional DCB controller. By deriving the differential functions of the DCB control algorithm, the small signal relationship between the input and output of DCB controller is explored. Furthermore, based on the relationship, the LDCB controller is formed through three parallel feed loops to the duty ratio. As a linear control approach, the achieved LDCB controller is greatly simplified for implementation. This not only saves the hardware cost, but also reduces the calculation lag, which provides potential to improve the switching frequency. Besides, since the LDCB controller shares the same small signal model as that of DCB controller, it achieves similar control loop bandwidth and transient performance. Effectiveness of the proposed LDCB control is verified by zero/pole plots, transient analyses and experimental results.
Polarization independent wavelength conversion using fiber four-wave mixing with two orthogonal pump lights of different frequencies (1994)

This paper describes polarization independent wavelength conversion, utilizing fiber four-wave mixing. By using two orthogonal pump lights having different frequencies, the baseband signal of the wavelength converted light is insensitive to the polarization state of the original signal light. Experiments that include bit error measurements confirm the polarization independent operation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evolution of microprocessor based control systems in upper extremity prosthetics (2003)

The recent emergence of microprocessor based prosthetic control for the individual with upper limb deficiency has significantly expanded the spectrum of treatment options and inclusion criteria for this patient population. Microprocessors can accept
Fibre-optical strain gauge (1978)

The transit time of a circulating light pulse in a 10–1000 m long multinode optical fibre is used to measure the absolute length of the fibre and also its length variations with a reproducibility of ± 0.2 mm. The arrangement represents a fibre-optical strain gauge for use on long arbitrarily shaped paths.
Two-dimensional Non-MEMS pointing mirror for free space communication (2012)

A two-dimensional pointing mirror for a laser beam deflection is presented. The mirror is primarily aimed for the pointing of a laser beam in the free space communication. The deflection of the mirror is accomplished by means of three voice coil actuators used in hard disk drives.
68 REPRODUCTIVE PERFORMANCE OF CLONED BULLS (2004)

The generation of cloned animals by somatic cell nuclear transfer has been reported in a number of countries worldwide. However, progress has been impeded by the extremely low efficiency of cloning and health of some of the cloned animals. Surprisingly, little is known of the reproductive performance of viable clones when compared to the original cell donor, given that a major motivation of cloning is dissemination of superior genotypes. The aim of this study was to compare semen collected from three cloned bulls (Clones A1, B1, and B2) to that of the original donor bulls (Donors A and B). Parameters examined included ejaculate volume, sperm concentration and the motility characteristics of frozen/thawed semen using computed-assisted semen analysis (Hamilton Thorne Biosciences, Inc., Beverly, MA, USA). The fertilization ability of each semen sample was examined using in vitro matured oocytes derived from abattoir-source ovaries. Frozen/thawed semen samples from donor and cloned bulls were prepared on a Percoll gradient and diluted with fertilization medium to a concentration of 1 million sperm/mL prior to fertilization (IVF). The number of blastocysts and total cell counts were analyzed on Day 7 of culture. Finally, in vitro-fertilized blastocysts (Day 7) were transfer to synchronized recipients (n = 49) to examine in vivo development. Proportional data for the in vitro development of embryos and subsequent pregnancy rates were analyzed by chi-square test, and embryo cell numbers were analyzed using Student's t-test. Progressive motility percentage between donor and cloned bull did not differ: Donor A (62.25 ± 3.89, n = 12); Donor B (66.69 ± 4.47, n = 13); Clone A1 (71.37 ± 8.57, n = 8); Clone B1 (73.75 ± 2.42, n = 12); Clone B2 (72.41 ± 3.26, n = 12). No obvious differences in kinetic motility parameters were evident between cloned and non-cloned donor animals. However, blastocyst rates were significantly higher in cloned bulls (Clone A1: 30.9%, 81/262; Clone B1: 34.4%, 98/285; and Clone B2: 42.9%, 120/280) compared to donor bulls (Donor A: 20.7%, 54/261; Donor B: 20.9%, 76/364). Total embryo cell numbers did not differ significantly between donor bulls (Donor A: 138.3 ± 5.3, n = 39; Donor B: 133.2 ± 5.2, n = 47) and cloned bulls (Clone A1; 126.3 ± 4.4, n = 45; Clone B1: 134.4 ± 7.1, n = 26; and Cloned B2: 140.1 ± 3.9, n = 46). Initial pregnancy rates on Day 30 were also not different between Donor A (42.3%, 11/26) and Clone A1 (47.8%, 11/23). Preliminary observations from the small data set on postpubertal cloned bulls indicate that semen production, semen morphology, and reproductive performance (in vitro and in vivo) were similar in terms of semen characteristics and reproductive performances when compared to their original donor bulls.
A circuit technology for sub-10-ns ECL 4-Mb BiCMOS DRAM's (1991)

The feasibility of realizing an emitter-coupled-logic (ECL) interface 4-Mb dynamic RAM (DRAM) with an access time under 10 ns using 0.3- mu m technology is explored, and a deep submicrometer BiCMOS VLSI using this technology is proposed. Five aspects of such a DRAM are covered. They are the internal power supply voltage scheme using on-chip voltage limiters, an ECL DRAM address buffer with a reset function and level converter, a current source for address buffers compensated for device parameter fluctuation, an overdrive rewrite amplifier for realizing a fast cycle time, and double-stage current sensing for the main amplifier and output buffer. Using these circuit techniques, an access time of 7.8 ns is expected with a supply current of 198 mA at a 16-ns cycle time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice (2020)

Evidence suggests that neutrophils contribute to thrombosis via several mechanisms, including neutrophil extracellular traps (NETs) formation. Integrin α9β1 is highly expressed on neutrophils when compared with monocytes. It undergoes affinity upregulation on neutrophil activation, and stabilizes adhesion to the activated endothelium. The role of integrin α9 in arterial thrombosis remains unexplored. We generated novel myeloid cell-specific integrin α9-/- mice (α9fl/flLysMCre+) to study the role of integrin α9 in arterial thrombosis. α9fl/fl littermates were used as controls. We report that α9fl/flLysMCre+ mice were less susceptible to arterial thrombosis in ferric chloride (FeCl3) and laser injury-induced thrombosis models with unaltered hemostasis. Neutrophil elastase-positive cells were significantly reduced in α9fl/flLysMCre+ mice concomitant with reduction in neutrophil count, myeloperoxidase levels, and red blood cells in the FeCl3 injury-induced carotid thrombus. The percentage of cells releasing NETs was significantly reduced in α9fl/flLysMCre+ mouse neutrophils stimulated with thrombin-activated platelets. Furthermore, we found a significant decrease in neutrophil-mediated platelet aggregation and cathepsin-G secretion in α9fl/flLysMCre+ mice. Transfusion of α9fl/fl neutrophils in α9fl/flLysMCre+ mice restored thrombosis similar to α9fl/fl mice. Treatment of wild-type mice with anti-integrin α9 antibody inhibited arterial thrombosis. This study identifies the potential role of integrin α9 in modulating arterial thrombosis.
Comparison of Glucose Levels in Dermal Interstitial Fluid and Finger Capillary Blood (2001)

Alternative methods for self-monitoring of blood glucose have been pursued by many researchers, largely in response to evidence gathered in several long-term studies of patients with diabetes mellitus. These studies suggest that long-term complications of the disease may be mitigated if the disease is intensively managed, a component of which is increased monitoring. Many of the alternative methods utilize interstitial fluid (ISF) as the diagnostic fluid, rather than finger blood. A time lag in the distribution of glucose from blood to the interstitium has been observed by many, with estimates of lag time varying from none to 45 min. Dermal ISF was sampled from diabetic subjects in two tests and compared to finger blood glucose. In the first test, data were collected over time in a manner that allowed a cross-correlation analysis to predict an average lag time. Information from this test was then used as input to a data collection format for a method comparison test of 691 patients with diabetes in which ISF data were collected immediately after the finger blood reference and 15 min after the reference. An average lag time of about 25 min was determined from the cross-correlation analysis, with the correlation error reduced by three-fourths within a 15-min lag time. In the method comparison test, the correlation coefficient between finger blood glucose and ISF glucose improved from 0.923 to 0.951, and the percentage of data in the A zone of the Clarke Error Grid rose from 80.2% to 90.6% for the ISF glucose data collected at no lag and 15-min lag, respectively. Dermal ISF glucose measurement might be a reasonable alternative to blood glucose measurement for patients routinely monitoring ambient glycemia, although more testing in the sensitive hypoglycemic range is needed to clarify what might happen in cases of rapidly changing glucose.
No censorship (1981)

I have no sympathy with the various illiberal regimes, from South America and South Africa to the dictators in the Kremlin, but I do not think the advice tendered by N J Eyre in the June issue of Physics Bulletin (p164) should even be considered. What he is advocating is censorship and (worse) that censorship should be an act of policy.
Securing Application with Software Partitioning: A case study using SGX (2017)

Application size and complexity are the underlying cause of numerous security vulnerabilities in code. In order to mitigate the risks arising from such vulnerabilities, various techniques have been proposed to isolate the execution of sensitive code from the rest of the application and from other software on the platform (e.g. the operating system). However, even with these partitioning techniques, it is not immediately clear exactly how they can and should be used to partition applications. What overall partitioning scheme should be followed; what granularity of the partitions should be. To some extent, this is dependent on the capabilities and performance of the partitioning technology in use. For this work, we focus on the upcoming Intel Software Guard Extensions (SGX) technology as the state-of-the-art in this field. SGX provides a trusted execution environment, called an enclave, that protects the integrity of the code and the confidentiality of the data inside it from other software, including the operating system. We present a novel framework consisting of four possible schemes under which an application can be partitioned. These schemes range from coarse-grained partitioning, in which the full application is included in a single enclave, through ultra-fine partitioning, in which each application secret is protected in an individual enclave. We explain the specific security benefits provided by each of the partitioning schemes and discuss how the performance of the application would be affected. To compare the different partitioning schemes, we have partitioned OpenSSL using four different schemes. We discuss SGX properties together with the implications of our design choices in this paper.