gebhart/patrepeval huggingface dataset:
The effect of ring size variation on the structure and stability of lanthanide(<scp>iii</scp>) complexes with crown ethers containing picolinate pendants (2010)

The coordination properties of the macrocyclic receptor N,N'-bis[(6-carboxy-2-pyridyl)methylene]-1,10-diaza-15-crown-5 (H(2)bp15c5) towards the lanthanide ions are reported. Thermodynamic stability constants were determined by pH-potentiometric titration at 25 °C in 0.1 M KCl. A smooth decrease in complex stability is observed upon decreasing the ionic radius of the Ln(III) ion from La [log K(LaL) = 12.52(2)] to Lu [log K(LuL) = 10.03(6)]. Luminescence lifetime measurements recorded on solutions of the Eu(III) and Tb(III) complexes confirm the absence of inner-sphere water molecules in these complexes. (1)H and (13)C NMR spectra of the complexes formed with the diamagnetic La(III) metal ion were obtained in D(2)O solution and assigned with the aid of HSQC and HMBC 2D heteronuclear experiments, as well as standard 2D homonuclear COSY and NOESY spectra. The (1)H NMR spectra of the paramagnetic Ce(III), Eu(III) and Yb(III) complex suggest nonadentate binding of the ligand to the metal ion. The syn conformation of the ligand in [Ln(bp15c5)](+) complexes implies the occurrence of two helicities, one associated with the layout of the picolinate pendant arms (absolute configuration Δ or Λ), and the other to the five five-membered chelate rings formed by the binding of the crown moiety (absolute configuration δ or λ). A detailed conformational analysis performed with the aid of DFT calculations (B3LYP model) indicates that the complexes adopt a Λ(λδ)(δδλ) [or Δ(δλ)(λλδ)] conformation in aqueous solution. Our calculations show that the interaction between the Ln(III) ion and several donor atoms of the crown moiety is weakened as the ionic radius of the metal ion decreases, in line with the decrease of complex stability observed on proceeding to the right across the lanthanide series.
Adiabatic RARE imaging (2003)

Abstract The practical implementation of ultra‐fast spin‐echo, or RARE imaging with adiabatic RF pulses and surface coil transmission at 7 T is described. Despite the large RF inhomogeneities, the adiabatic character of the 180° BIR‐4 refocusing pulses ensures optimal sensitivity and minimal image artifacts. An internal ‘phase‐cycle’ is used to remove spurious unwanted coherences. The short T 2 relaxation times in rat brain at 7 T demand a centric, rather than a linear coverage of k ‐space in order to avoid excessive signal loss. T 2 relaxation during k ‐space coverage also leads to image blurring, which can be counteracted by interleaved k ‐space sampling. The coverage of k ‐space in four acquisitions provides high‐quality anatomical images comparable to conventional spin‐echo images. A two‐scan RARE implementation provides sufficient spatial and temporal resolution for most applications. Quantitative mapping of T 1 relaxation and cerebral blood flow changes during forepaw stimulation in the rat are demonstrated. Copyright © 2003 John Wiley & Sons, Ltd.
Emerging treatment strategies for trauma-induced coagulopathy (2011)

Future treatment of trauma-induced coagulopathy may be based on systemic antifibrinolytics, local haemostatics and individualized point-of-care-guided rational use of coagulation factor concentrates such as fibrinogen, prothrombin complex concentrate, recombinant factor VIIa and factor XIII. The authors speculate that timely and rational use of coagulation factor concentrates will be more efficacious and safer than ratio-driven use of transfusion packages of allogeneic blood products. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Distinct roles of the ERK pathway in modulating apoptosis of Ras‐transformed and non‐transformed cells induced by anticancer agent FR901228 (2004)

Ectopic expression of oncogenic H‐Ras in cells results in increases of cell susceptibility to the anticancer agent FR901228. Investigating the roles of Ras‐induced pathways in FR901228‐induced apoptosis, we have found that the phosphatidylinositol 3‐kinase pathway plays an anti‐apoptotic role, whereas the stress‐activated protein kinase p38 pathway plays a pro‐apoptotic role in FR901228‐induced apoptosis. Interestingly, the extracellular signal‐regulated kinase (ERK) pathway plays an anti‐apoptotic role in non‐transformed cells; however, it plays a pro‐apoptotic role in Ras‐transformed cells in response to FR901228 treatment. An essential role of the ERK pathway in regulating caspase‐3 contents may contribute to its pro‐apoptotic role in Ras‐transformed cells.
Early Detection of Infusion Set Failure During Insulin Pump Therapy in Type 1 Diabetes (2016)

The proposed method for early detection of infusion set failure based on glucose sensor and insulin data demonstrated favorable results on retrospective data and may be implemented as an additional safeguard in a future fully automated closed-loop system.
Micro-Doppler analysis of pedestrians in ISAR imaging (2008)

In radar imaging, it's well known that relative motion or deformation of parts of illuminated objects induce additional features in the Doppler frequency spectra. These features are called micro-Doppler effect and appear as sidebands around the central Doppler frequency. They can provide valuable information about the structure of the moving parts and may be used for identification purposes. Previous papers have mostly focused on ID micro-Doppler analysis by V.V.Chen et al (2002). In this paper, we propose to emphasize the analysis of such "non stationary targets" using a 2D imaging space, using both the micro-Doppler and a high range resolution analysis. As in 2D-ISAR imaging, range separation enables us to better discriminate the various effects caused by the time varying reflectors. We will focus our study on the human motion. Thanks to the micro-Doppler signature we are able to extract information on the gait of pedestrians. We will show examples on simulated and experimental data.
Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds (2020)

Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but a major drawback is still the low bioavailability of these compounds, as well as their instability towards pH, temperature, and light in some cases. Nanotechnology has emerged as an alternative to overcome these limitations, and the use of lipidic encapsulation systems is a promising technique to achieve an efficient drug delivery, protecting molecules from external factors and improving their bioavailability. In this review, solid lipid nanoparticles and nanostructured lipid carriers are highlighted as an important tool for the improvement of the bioavailability and stability of natural phenolic compounds, including their preparation methods and functionalization approaches and the discussion of several applications for putative use in cosmetic and pharmacologic products.
An access control model and its use in representing mental health application access policy (1996)

The paper considers an access control model and proposes extensions to it to deal with authentication and revocation. The model is then applied to represent access control policy in a mental health system. In the first part of the paper, extensions to the schematic protection model (SPM) are presented. The authentication and revocation extensions are independent of one another in the sense that each one affects a different part of the decision algorithm. The extensions comprise a modification of the syntax to be able to represent the new concepts and, more importantly, a modification of the decision algorithm for the safety problem to take these changes into account. We introduce the concept of conditional tickets and use it to provide authentication. Apart from this, we have found this concept to be useful in modeling systems. Hence we have separated this (syntactical) issue from the definition of the new algorithm. The second part considers the access policy for a mental health application. We have used the extensions of SPM to model part of this access policy. Even with our extensions, SPM still remains a monotonic model, where rights can be removed only in very special cases, and this makes it impossible to represent all the aspects of the problem. Other than to serve as an example for the extensions we propose, the paper also helps to separate aspects of this access control policy which are inherently monotonic from parts which are defined in a non-monotonic way, but can still be represented in a monotonic model.
Integrating a Triboelectric Nanogenerator and a Zinc‐Ion Battery on a Designed Flexible 3D Spacer Fabric (2018)

Abstract Powering flexible electronics by wearable energy‐storage or energy‐harvesting devices has attracted enormous research interest recently. However, the continual powering offered by individual energy‐storage devices, such as rechargeable batteries or supercapacitors, becomes problematic once the energy stored is fully discharged. Therefore, the integration of energy‐storage and energy‐harvesting techniques becomes a feasible approach to provide a continual power supply for flexible and wearable electronics. Herein, an integrated flexible and wearable triboelectric nanogenerator (TENG) and rechargeable Zn‐ion battery (ZIB) system based on a flexible 3D spacer fabric is proposed as a promising wearable power unit for powering personal electronic devices. The energy harvested by the TENG from human motion can be utilized to refill the ZIB once its stored energy is exhausted. Moreover, the power unit can be easily scaled up to multipixel, due to the compatibility of the fabric with the textile industry, which renders the system with promise as a practical wearable personal power station in the future.
2-.beta.-D-ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastases (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-.beta.-D-ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastasesR. K. Robins, P. C. Srivastava, V. L. Narayanan, J. Plowman, and K. D. PaullCite this: J. Med. Chem. 1982, 25, 2, 107–108Publication Date (Print):February 1, 1982Publication History Published online1 May 2002Published inissue 1 February 1982https://pubs.acs.org/doi/10.1021/jm00344a002https://doi.org/10.1021/jm00344a002research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Thermoelectric properties of sintered magnesium compounds (2002)

The thermoelectric properties of the sintered magnesium compounds such as magnesium silicide and magnesium stannide have been researched in order to apply to a thermoelectric power generation system using combustion heat of municipal solid waste. Temperature dependencies of thermoelectric properties such as Seebeck coefficient, electrical resistivity and thermoelectric power factor are measured for the temperature range from 300 K to 770 K. The non-dimensional figure-of-merit for the sintered magnesium silicide is obtained about 0.4 at 600 K in the initial stage. The durability of magnesium compound elements is also discussed.
High-precision interpolation using two-phase type PLL for encoders that have distorted waveforms (2002)

The authors tried to use two-phase type PLL (phase locked loops) of non-sinusoidal waveforms to interpolate distorted waveforms of incremental encoders. In order to obtain high-precision interpolation, the authors propose an iterative method to approximate the waveforms of the encoder. This method does not require precise sinusoidal waveforms of encoders for detecting positions with high resolution and high precision. The authors discuss the proposed method and present simulation and experimental results.
The Granularity of Medical Narratives and Its Effect on the Speed and Completeness of Information Retrieval (1998)

Dividing voluminous free-text clinical narratives into labeled segments makes patient-related information retrieval easier. However, too much subdivision slows retrieval. Study results suggest that a coarser granularity is required for optimal information retrieval than for structured data entry. Validation of these conclusions in real-life clinical practice is recommended.
Mapping large scale environments using relative position information among landmarks (2006)

The main contribution of this paper is a new SLAM algorithm for the mapping of large scale environments by combining local maps. The local maps can be generated by traditional extended Kalman filter (EKF) based SLAM. Relationships between the locations of the landmarks in the local map are then extracted and used in an extended information filter (EIF) to build a global map. An important feature is that the information matrix for the global map is exactly sparse, leading to significant computational advantages. This paper thus presents an algorithm that combines the advantages of both the existing local map joining SLAM algorithms, which reduces the linearization error in EKF SLAM and allows computationally demanding global map fusion to be scheduled off-line, and the decoupled SLAM (D-SLAM) algorithm, which provides an efficient strategy for building large maps using relative location information. The effectiveness of the new algorithm is illustrated through computer simulations.
Direct Reductive Amination of Ketones: Structure and Activity of <i>S</i>‐Selective Imine Reductases from <i>Streptomyces</i> (2014)

Abstract The importance and structural diversity of chiral amines is well‐demonstrated by the myriad nonenzymatic methods for their chemical production. In nature, the production of amines is performed by transamination rather than by reduction of an imine precursor derived from the corresponding ketone. Imine reductases, however, show great potential in the reduction of cyclic imines that are stable towards hydrolysis in aqueous reaction media. Here, we report the catalytic activity of two S ‐selective imine reductases towards 3,4‐dihydroisoquinolines and 3,4‐dihydro‐β‐carbolines and their activity in the direct reductive amination of ketone substrates. The crystal structures of the enzyme from Streptomyces sp. GF3546 in complex with the cofactor NADPH and from Streptomyces aurantiacus in native form have been solved and refined to a resolution of 1.9 Å.
Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer (2004)

Urokinase-type plasminogen activator (uPA) and its inhibitor, PAI-I, play a key role in tumor invasion and metastasis. They were the first novel tumor biological factors to be validated at the highest level of evidence (LOE I) regarding their clinical utility in breast cancer. Their antigen levels are determined in tumor tissue extracts by standardized, quality-assured immunometric assays (ELISA). Since the late 1980s, numerous independent studies have demonstrated that patients with low levels of uPA and PAI-I in their primary tumor tissue have a significantly better survival than patients with high levels of either factor. These prognostic data have recently been validated by an EORTC (European Organization for Research and Treatment of Cancer) pooled analysis comprising more than 8,000 breast cancer patients. In addition, results from a multicenter prospective randomized therapy trial in node-negative breast cancer ("Chemo N(0)") showed that node-negative breast cancer patients with low levels of uPA and PAI-I in their primary tumor have a very good prognosis, and may thus be candidates for being spared the burden of adjuvant chemotherapy. In contrast, node-negative patients with high uPA/PAI-I are at substantially increased risk of disease recurrence, comparable to that of patients with three or more tumor cell positive axillary lymph nodes. The "Chemo N(0)" trial as well as retrospective data also indicate that these high-risk patients benefit from adjuvant chemotherapy. In conclusion, over a period of about 15 years sufficient evidence has been put forward to demonstrate that determination of uPA and PAI-I in primary breast cancer patients supports risk-adapted individualized therapy decisions, particularily in patients with node-negative disease.
Synthesis, characterization and biological activities of novel 2-methyl-quinazolin-4(3H)-ones (2003)

In the present study, a novel series of 2-methyl-qninazolin-4(3H)-ones were synthesized and characterized by IR, 1H-NhlR, 13C-NMR and mass spectral analysis. The synthesized compounds were screened for analgesic (100, 200 and 400 mg/kg), antiinflammatory (200 and 400 mg/kg), antibacterial (Bacillus subtilis, Bacillus cereus, Staphylococcus epidermidis, Micrococcus Iufeus and Escherichia coli) and antifungal (Candida albicans and Aspergillus niger) activities. The minimum inhibitory concentrations of the compounds were also ascertained by agar dilution method. Graded dose response was observed with the compounds. 6,8-dibromo-2-methyl-3-(4'-morpholino-phenyl)- 4(3H)-one (2) exhibited the highest analgesic and antiinflammatory activity. 6-Bromo-2-methyl- 3-(4'-morpholino-phenyl)-quinazolin-4-(3H)-one (1) was found to exhibit the highest antimicrobial activity. All the compounds exhibited significant activity against the bacteria and fungi tested.
A 10-Gb/s receiver with series equalizer and on-chip ISI monitor in 0.11-/spl mu/m CMOS (2005)

A 10-Gb/s receiver is presented that consists of an equalizer, an intersymbol interference (ISI) monitor, and a clock and data recovery (CDR) unit. The equalizer uses the Cherry-Hooper topology to achieve high-bandwidth with small area and low power consumption, without using on-chip inductors. The ISI monitor measures the channel response including the wire and the equalizer on the fly by calculating the correlation between the error in the input signal and the past decision data. A switched capacitor correlator enables a compact and low power implementation of the ISI monitor. The receiver test chip was fabricated by using a standard 0.11-/spl mu/m CMOS technology. The receiver active area is 0.8 mm/sup 2/ and it consumes 133 mW with a 1.2-V power supply. The equalizer compensates for high-frequency losses ranging from 0 dB to 20 dB with a bit error rate of less than 10/sup -12/. The areas and power consumptions are 47 /spl mu/m /spl times/ 85 /spl mu/m and 13.2 mW for the equalizer, and 145 /spl mu/m /spl times/ 80 /spl mu/m and 10 mW for the ISI monitor.
Nycthemeral rhythm in adrenal responsiveness to ACTH (1978)

Adrenal adenosine 3',5'-cyclic monophosphate (cAMP) and corticosterone responses to exogenous ACTH were found to be about 2.5 times greater in the evening (at lights off) than in the morning (at lights on) in rats. The rhythm in adrenal responsiveness to ACTH was found to persist in rats treated with dexamethasone 15 and 3 h before exogenous ACTH (in the presumed absence of a rhythm in endogenous ACTH). Treatment with p-chlorophenylalanine did not affect the daily rise in circulating ACTH levels but did abolish the rhythm in adrenal responsiveness to ACTH. The magnitude of the rhythm in adrenal responsiveness to ACTH is greater than the magnitude of the rhythm in ACTH. Because the rhythms are dissociable, we conclude that in vivo measurements of adrenal corticosteroid levels do not necessarily reflect ACTH levels.
Immune response gene control of determinant selection. III. Polypeptide fragments of insulin are differentially recognized by T but not by B cells in insulin immune guinea pigs. (1981)

Synthetic polypeptides corresponding to restricted regions of the B chain of insulin were used to evaluate immune response gene control of guinea pigs immune to native insulin. The amino acids necessary for recall of immune memory were assessed at the level of the T cell by use of peptides 8 to 16 amino acids in length, representative of the amino terminus of the insulin B chain to induce antigen-specific proliferation and help for antibody formation. A single histidine residue in the 10th position of the B chain is critical for T cell activation. In addition, immune response genes operating in the macrophage discern the presence or absence of this residue and activate the appropriate T cell clones. Although receptor V region sharing may exist for T and B cells immune to globular proteins, it cannot be demonstrated by antigen specificity, since T proliferation and generation of T helper cells in response to intact insulin can be elicited by synthetic fragments that do not correspondingly induce antibodies that recognize the native molecule.
Inverter miniaturizing technologies for EV/HEV applications (2002)

In this paper, an integrated intelligent power drive unit (IPU) is introduced as the next generation electric power module and inverter for EV/HEV. The IPU designs are based on new concepts to achieve a very compact overall structure, high reliability, high functionality and high efficiency. At first, the technologies to miniaturize the inverter are introduced and the benchmarks between the current inverter system using IPM (intelligent power module) and using IPU are shown. Finally, to verify the validity of IPU design, experimental data are shown.
Self‐Aligned Megahertz Organic Transistors Solution‐Processed on Plastic (2015)

The processing of complex nanoscale electronic structures on plastic substrates is a significant challenge, requiring the combination of low temperature, nonaggressive, and high resolution methods. Here a scalable process flow on plastic is presented tbat enables the fabrication of flexible nano­imprinted organic field‐effect transistors (OFETs) with self‐aligned contacts and solution‐processed semiconductor and dielectric layers, at processing temperatures ≤ 150 °C. OFETs are fabricated with device cutoff frequencies f > 1 MHz at low operating bias V DS = −15 V. The technique allows the patterning of metal structures over four orders of magnitude from 375 nm to 1 mm without the need for a rigid carrier, and provides a fabrication pathway to high performance nanostructured organic circuitry.
"RF and THz Identification using a new generation of chipless RFID tags" (2011)

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