gebhart/patrepeval huggingface dataset:
KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells (2009)

Administration of Paclitaxel to patients with high percentage Type I cancer cells could have detrimental effects due to Paclitaxel-induced enhancement of NF-kappaB and ERK activities, and cytokine production (e.g. IL-6), which promote chemoresistance and tumor progression. ARRY-520 has similar anti-tumor activity in EOC cells as that of Paclitaxel. However, unlike Paclitaxel, it does not induce these pro-tumor effects in Type I cells. Therefore, the KSP inhibitor ARRY-520 may represent an alternative to Paclitaxel in this subgroup of EOC patients.
Discrimination of <i>Arabica</i> and <i>Robusta</i> in Instant Coffee by Fourier Transform Infrared Spectroscopy and Chemometrics (1996)

Two species of coffee bean have acquired worldwide economic importance: these are, Coffea Arabica and Coffea Canephora variant Robusta. Arabica beans are valued most highly by the trade, as they are considered to have a finer flavor than Robusta. In this work, Fourier transform infrared spectroscopy is explored as a rapid alternative to wet chemical methods for authentication and quantification of coffee products. Principal component analysis (PCA) is applied to spectra of freeze-dried instant coffees, acquired by DRIFT (diffuse reflection infrared Fourier transform) and ATR (attenuated total reflection) sampling techniques, and reveals clustering according to coffee species. Linear discriminant analysis of the principal component scores yields 100% correct classifications for both training and test samples. The chemical origin of the discrimination is explored through interpretation of the PCA loadings. Partial least squares regression is applied to spectra of Arabica and Robusta blends to determine the relative content of each species. Internal cross-validation gives a correlation coefficient of 0.99 and a standard error of prediction of 1.20% (w/w), illustrating the potential of the method for industrial off-line quality control analysis. Keywords: Coffee; discrimination; infrared; spectroscopy
Principal components analysis based control of a multi-dof underactuated prosthetic hand (2010)

This work demonstrates the effectiveness of a bio-inspired system successfully conjugating the advantages of an underactuated, anthropomorphic hand with a PCA-based control strategy, and opens up promising possibilities for the development of an intuitively controllable hand prosthesis.
From death to final disposition (2012)

In this paper, we describe collaborative processes and stakeholders involved in the period from when a person dies until they are laid to rest: the funeral, final disposition of the body, and (in some circumstances) victim identification. The rich mixture of technologies currently deployed during this brief period are categorized and critically analyzed. We then reflect on the implications of our findings, both for the design of technology that takes the end of life into account, and for the wider HCI community.
Contraction of Urinary Bladder by Central Norepinephrine Originating in the Locus Coeruleus (1988)

Studies were performed to elucidate the role of the locus coeruleus, which is rich in norepinephrine-containing cell bodies, in vesical function using alpha-chloralose anesthetized cats. Stimulation of the locus coeruleus caused contraction of the urinary bladder, which was not affected by transection of the bilateral hypogastric nerves, but blocked by intravenous administration of hexamethonium, a ganglion blocking agent. In animals with transected hypogastric nerves, the locus coeruleus-induced contraction was inhibited by intrathecal administration of phentolamine (alpha-blocker) and prazosin (alpha 1-blocker), but not affected by intrathecal sotalol (beta-blocker) or yohimbine (alpha 2-blocker). In animals treated with reserpine, the locus coeruleus-induced contraction was enhanced by intravenous application of L-dopa, a precursor of norepinephrine. These results suggest that norepinephrine derived from the locus coeruleus activated preganglionic neurons in the sacral intermediolateral nuclei via alpha 1-receptors, thereby producing urinary bladder contraction.
Applications of X-Ray Computed Tomography in Particulate Systems (1992)

X-ray computed tomography (CT) is an ideal technique for investigating the internal structure of multiphase materials in a noninvasive and nondestructive manner. CT technology used in conjunction with specialized algorithms and advanced computer facilities can be used to provide quantitative information in addition to being an ideal medium for scientific visualization. This paper reviews some advanced reconstruction algorithms and examines two cases in which CT has been successfully used: (1) coal washability analysis and (2) density gradient determination in an air-sparged hydrocyclone (ASH) flotation.
The IEEE 802.11s Extended Service Set Mesh Networking Standard (2008)

Today, municipalities are planning to deploy metro-scale two-tier wireless mesh networks at a rapid pace. Fittingly, the IEEE 802.11s standard is being developed to allow interoperability between heterogeneous mesh network devices. In this article we describe and discuss how the initial standard addresses key factors for standardization of these networks: Efficient allocation of mesh resources at the routing and MAC layers. Protection and conservation of the network resources via security and energy efficiency. Assurance of fairness and elimination of spatial bias via mesh congestion control. We draw on examples from existing two-tier deployments, simulations, and analytical models to motivate these enhancements within the standard.
Liquid Chromatographic Determination of Vitamin D in Infant Formula (1989)

A method is described for the determination of vitamins D2 + D3 in milk- and soy-based infant formula. Vitamins D2 and D3 are extracted from the saponified sample and converted to isotachysterols with acidified butanol. Reverse-phase liquid chromatography (LC) is used to remove interferences, and total vitamin D is quantitated using normal-phase LC. Recoveries of spiked samples averaged 97.6% for milk-based infant formula, and 98.8% for soy-based infant formula. This method quantitates vitamin D2 + D3 in infant formulas containing as low as 40 IU/qt when prepared according to label direction.
<title>Heterodyne interferometer for in situ and in vivo vibration measurements in the inner ear</title> (1995)

Investigation of the inner ear is still the subject of basic research. The concept of an active filtering process in the mechano-electrical transfer mechanism in the inner ear (cochlea) was introduced. In this paper an optical approach detecting microvibrations is discussed. A fiber optic heterodyne interferometer with a miniaturized sensorhead was built. The fibers ensure flexibility and easy handling of the interferometer whereas the miniaturized sensorhead allows a non-invasive approach to the organ of Corti. In heterodyne interferometry as compared to classical interferometry two slightly different light frequencies for the reference and object beams are used. The vibration of the object is detected as a modulation of the phase of the detector signal. To obtain the information on the vibration two methods were analyzed and applied: namely measuring the amplitude of the sidebands in the spectrum of the modulated signal and secondly signal demodulation. It is possible to detect amplitudes down to 0.3 angstrom in a frequency range of 500 Hz to 50 kHz with a simulated object reflectivity of 0.02%.
A New Apparatus to Evaluate Lubricants for Space Applications - The Spiral Orbit Tribometer (SOT) (2000)

Lubricants used in space mechanisms must be thoroughly tested prior to their selection for critical applications. Traditionally, two types of tests have been used: accelerated and full-scale. Accelerated tests are rapid, economical, and provide useful information for gross screening of candidate lubricants. Although full-scale tests are more believable, because they mimic actual spacecraft conditions, they are expensive and time consuming. The spiral orbit tribometer compromises between the two extremes. It rapidly determines the rate of tribochemically induced lubricant consumption, which leads to finite test times, under realistic rolling/pivoting conditions that occur in angular contact bearings.
Automated Tiering in a QoS Environment Using Coarse Data (2013)

We present a method for providing automated performance management for a storage array with quality of service demands. Our method dynamically configures application data to heterogeneous storage devices, taking into account response time targets for the different applications. The optimization process uses widely available coarse counter statistics. We use analytical modeling of the storage system components and a gradient descent mechanism to minimize the target function. We verify the effectiveness of our optimization procedure using traces from real production systems, and show that our method improves the performance of the more significant applications, and can do so using only the coarse statistics. Our results show substantial improvements for preferred applications over an optimization procedure which does not take QoS requirements into account. We also present evidence of the complex behavior of real production storage systems, which has to be taken into account in the optimization process.
Multimodal sentiment analysis: Sentiment analysis using audiovisual format (2015)

Multimodal sentiment analysis is the analysis of emotions, attitude, and opinion from audiovisual format. A company can improve the quality of its product and services by analyzing the reviews about the product [5]. Sentiment analysis is widely used in managing customer relations. There are many textual reviews from which we cannot extract emotions by traditional sentiment analysis techniques. Some sentences in the textual reviews may derive deep emotions but do not contain any keyword to detect those emotions, so we used audiovisual reviews in order to detect emotions from the facial expressions of the customer. In this paper we take audiovisual input and extract emotions from video and audio in parallel from audiovisual input, finally classify the overall review as positive, negative or neutral based on the emotions detected.
Problem Description: Reasons For Performing Context Transfers Between Nodes in an IP Access Network (2002)

In IP access networks that support host mobility, the routing paths between the host and the network may change frequently and rapidly. In some cases, the host may establish certain transfer candidate services on subnets that are left behind when the host moves. Examples of such services are Authentication, Authorization, and Accounting (AAA), header compression, and Quality of Service (QoS). In order for the host to obtain those services on the new subnet, the host must explicitly re-establish the service by performing the necessary signaling flows from scratch. In some cases, this process would considerably slow the process of establishing the mobile host on the new subnet. An alternative is to transfer information on the existing state associated with these services, or context, to the new subnet, a process called context transfer. This document discusses the desirability of transfer for facilitating seamless IP mobility.
A Facile Approach to Arylacetaldehydes via Polymeric Palladium Catalyst (1991)

Several arylacetaldehydes 5 were synthesized in moderate yields via Heck reaction of acrylamide (1) with substituted iodobenzenes 2 in the presence of the polymeric catalyst -phenyl-(1,10-phenanthroline)-palladium(0) [-ph-phen.Pd(0)] followed by Hofmann reaction and subsequent hydrolysis.
Structural Material Anomaly Detection System Using Water Chemistry Data. (1992)

Abstract The concept of an advanced water chemistry diagnosis system for detection of anomalies and preventive maintenance of system components is proposed and put into a concrete form. Using the analogy to a medical inspection system, analyses of water chemistry change will make it possible to detect symptoms of anomalies in system components. Then, correlations between water chemistry change and anomaly occurrence in the components of the BWR primary cooling system are analyzed theoretically. These fragmentary correlations are organized and reduced to an algorithm for the on-line diagnosis system using on-line monitoring data, pH and conductivity. By using actual plant data, the on-line diagnosis model system is verified to be applicable for early and automatic finding of the anomaly cause and for timely supply of much diagnostic information to plant operators. KEYWORDS: diagnostic techniqueson-line systemswater chemistrycrudBWR type reactorsanomaly detection systemstructural materialspH valueselectric conductivitycorrelationsprediction model
Activation of Growth Hormone Short Loop Negative Feedback Delays Puberty in the Female Rat* (1981)

Implantation of GH in the median eminence of the hypothalamus of 23-day-old female rats tonically inhibited serum GH levels throughout prepubertal development (days 23-36) and depressed GH diurnal pulsatile release. Puberty was significantly delayed in GH-deficient animals, a delay associated with a blunted in vitro ovarian steroidal responsiveness to gonadotropins (particularly estradiol) and a marked decrease in prepubertal uterine weight, as evaluated 4, 7, and 13 days after GH implantation. The prepubertal body weight increase was also depressed. Neither ovarian weight nor serum levels of LH, FSH, PRL, or TSH were consistently altered by the GH implant. In addition, evaluation of pulsatile PRL release in 33-day-old rats revealed no difference between control and GH-deficient animals. Ovarian LH receptor content was lower in GH-implanted rats than in controls, suggesting that a decrease in LH receptors may be one of the mechanisms by which a chronic decrease in serum gH depressed the prepubertal ovarian estradiol and, to a lesser extent, the progesterone response to gonadotropins. A direct ovarian site of action for GH was indicated by the results of experiments in which GH was administered to immature hypophysectomized estrogen-treated rats. The in vitro ovarian progesterone response of the GH-treated animals to both hCG and human FSH was distinctly increased by prior in vivo GH treatment. This effect of GH was not reproduced either by the in vivo administration of LH at a dose calculated by RIA to be contaminating the GH preparation or by FSH at a dose that induced a marked increase in aromatase activity in the same ovaries. GH treatment of hypophysectomized rats failed to affect either aromatase activity or hCG-induced estradiol release, indicating that GH does not directly facilitate the production of estradiol by the ovary. The fact that intact rats with GH implants did not actually show a decrease in the ovarian estradiol response to hCG but, rather, failed to show an increased response at the same time as control animals strongly suggests that ovarian maturation was delayed in GH-deficient rats. It is suggested that, in addition to PRL, GH may also play a role in the process of prepubertal reproductive development by enhancing the steroidal response of the ovary to gonadotropins.
Smart Composite Nanosheets with Adaptive Optical Properties (2014)

We report efficient design and facile synthesis of size-tunable organic/inorganic nanosheets, via a straightforward liquid exfoliation-adsorption process, of a near percolating gold (Au) thin film deposited onto a branched polyethylenimine (bPEI) matrix. The nanosheets are stiff enough to sustain their two-dimensional (2D) nature in acidic conditions, yet flexible enough to undergo a perfect reversible shape transformation to 1D nanoscrolls in alkaline conditions. The shape transformations, and associated optical property changes, at different protonation states are monitored by transmission electron microscopy (TEM), atomic force microscopy (AFM), UV-visible spectroscopy and zeta potential measurements. Because of their large surface area, both nanosheets and nanoscrolls could be used as capturing substrates for surface-enhanced Raman scattering (SERS) applications.
The C536T Transition in the Tissue Factor Pathway Inhibitor (TFPI) Gene Does not Contribute to Risk of Venous Thrombosis among Carriers of Factor V Leiden (2000)

The C536T Transition in the Tissue Factor Pathway Inhibitor (TFPI) Gene Does not Contribute to Risk of Venous Thrombosis among Carriers of Factor V Leiden -
The Micro Craft iSTAR Micro Air Vehicle: Control System Design and Testing (2001)

The iSTAR Micro Air Vehicle (MAV) is a unique 9-inch diameter ducted air vehicle weighing approximately 4 lb. The configuration consists of a ducted fan with control vanes at the duct exit plane. This VTOL aircraft not only hovers, but it can also fly at high forward speed by pitching over to a near horizontal attitude. The duct both increases propulsion efficiency and produces lift in horizontal flight, similar to a conventional planar wing. The vehicle is controlled using a rate based control system with piezo-electric gyroscopes. The Flight Control Computer (FCC) processes the pilot’s commands and the rate data from the gyroscopes to stabilize and control the vehicle. First flight of the iSTAR MAV was successfully accomplished in October 2000. Flight at high pitch angles and high speed took place in November 2000. This paper describes the vehicle, control system, and ground and flight-test results .
Strong Acid Sites of Dealuminated Y Zeolites Prepared by Conventional Treatments and Isomorphous Substitution (1988)

The acidity of dealuminated Y zeolites prepared either by conventional treatments or isomorphous substitution has been characterized in detail through a microcalorimetric study of the adsorption of ammonia. In agreement with previous studies, microcalorimetry confirms that in steamed products, most of the strong acid sites are poisoned by cationic extra-framework Al species. These sites can be recovered by an optimized post-steaming acid leaching. Isomorphously substituted HY which is free of extra-framework cationic species possesses more acid sites than conventionally dealuminated solids with similar framework Si/AlIV ratio. The catalytic performances of the solids in the conversion of cyclohexene are in qualitative agreement with their acidic properties as determined by calorimetric experiments or other techniques such as TPD of ammonia and infrared spectroscopy.
The modern Japanese color lexicon (2017)

Despite numerous prior studies, important questions about the Japanese color lexicon persist, particularly about the number of Japanese basic color terms and their deployment across color space. Here, 57 native Japanese speakers provided monolexemic terms for 320 chromatic and 10 achromatic Munsell color samples. Through k-means cluster analysis we revealed 16 statistically distinct Japanese chromatic categories. These included eight chromatic basic color terms (aka/red, ki/yellow, midori/green, ao/blue, pink, orange, cha/brown, and murasaki/purple) plus eight additional terms: mizu ("water")/light blue, hada ("skin tone")/peach, kon ("indigo")/dark blue, matcha ("green tea")/yellow-green, enji/maroon, oudo ("sand or mud")/mustard, yamabuki ("globeflower")/gold, and cream. Of these additional terms, mizu was used by 98% of informants, and emerged as a strong candidate for a 12th Japanese basic color term. Japanese and American English color-naming systems were broadly similar, except for color categories in one language (mizu, kon, teal, lavender, magenta, lime) that had no equivalent in the other. Our analysis revealed two statistically distinct Japanese motifs (or color-naming systems), which differed mainly in the extension of mizu across our color palette. Comparison of the present data with an earlier study by Uchikawa & Boynton (1987) suggests that some changes in the Japanese color lexicon have occurred over the last 30 years.
Co-expression of wild-type and mutant olfactory cyclic nucleotide-gated channels: restoration of the native sensitivity to Ca2+ and Mg2+ blockage (2001)

In the pore of homomeric cyclic nucleotide-gated (CNG) channels, Ca(2+) and Mg(2+) bind to a set of glutamate residues, which in the bovine olfactory CNG channel are located at position 340. However, native CNG channels from olfactory sensory neurons are composed by the assembly of three different types of subunits, each having a different residue -- glutamate, aspartate or glycine -- at the position corresponding to the binding site for external Ca(2+) and Mg(2+). We co-expressed the wild-type principal alpha subunit with its mutants E340G and E340D in different combinations in Xenopus laevis oocytes, and measured Ca(2+) and Mg(2+) blockage in excised outside-out membrane patches. The comparison between our results and data from native olfactory CNG channels indicates that the presence of all three residues -- glutamate, aspartate and glycine -- in the different subunits, is necessary to restore the sensitivity to external Ca(2+) and Mg(2+) measured in native channels.
MECHANISMS IN ENDOCRINOLOGY: Primary HT and risk for breast cancer: a systematic review and meta-analysis (2011)

Our meta-analysis showed that hypothyroidism is not associated with increased risk for breast cancer and thyroid hormone replacement therapy does not reduce breast cancer prevalence; however, the heterogeneity of the studies analyzed precludes firm conclusions.
DESIGN OF DEPLOYABLE BAR STRUCTURE DEVELOPED FROM YOSHIMURA-PATTERN RIGID-ORIGAMI (2018)

We develop a new type of deployable bar structure that simulates the folding process of rigid origami called Yoshimura-pattern. Since Yoshimura-pattern origami has multi-DOFs (degrees-of-freedom), it can be folded symmetrically and asymmetrically with respect to parallel valley fold-lines. In our proposal, additional revolute joints are assigned to restrict asymmetric motion of the mechanism and reduce DOFs. To confirm the deployability, we evaluate the DOFs of the mechanisms in various states using singular value decomposition of equilibrium matrix. The size of bars and the offset of joints are rigorously considered. Small-scale physical models are also assembled to confirm the deployability.
Insulin-Like Growth Factor-I as a Candidate Metabolic Biomarker: Military Relevance and Future Directions for Measurement (2009)

Insulin-like growth factor (IGF)-I is a ubiquitous peptide hormone involved in a host of critical physiological processes (e.g., protein synthesis and glucose homeostasis) and has been suggested to be a biomarker reflecting health and metabolic status. In most cases (muscle, bone, tendon, body composition, and cognitive function), elevated IGF-I concentrations are considered beneficial; however, cancer remains a notable exception. While the fact that both increased and decreased IGF-I can be considered reflective of favorable and beneficial health outcomes may appear as a paradox, it is important to emphasize that, in both cases, measured IGF-I concentrations do offer important insight into physiological processes. The effects of military operational field training on the circulating IGF-I system are discussed within the context of novel measurement technologies that (1) are field expedient and (2) provide more meaningful information. Prospective experimental approaches involving physical activity that sample and measure IGF-I in the body's various biocompartments will provide greater insight into the complex role that IGF-I possesses. Minimally invasive technologies that are field expedient, cost-effective, and allow for continuous and real-time feedback will have the greatest likelihood of being adapted and used in military environments.