gebhart/patrepeval huggingface dataset:
A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/<i>lpr</i> Mice (2010)

Autoimmunity leads to the activation of innate effector pathways, proinflammatory cytokine production, and end-organ injury. Macrophage migration inhibitory factor (MIF) is an upstream activator of the innate response that mediates the recruitment and retention of monocytes via CD74 and associated chemokine receptors, and it has a role in the maintenance of B lymphocytes. High-expression MIF alleles also are associated with end-organ damage in different autoimmune diseases. We assessed the therapeutic efficacy of (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1), an orally bioavailable MIF antagonist, in two distinct models of systemic lupus erythematosus: the NZB/NZW F1 and the MRL/lpr mouse strains. ISO-1, like anti-MIF, inhibited the interaction between MIF and its receptor, CD74, and in each model of disease, it reduced functional and histological indices of glomerulonephritis, CD74(+) and CXCR4(+) leukocyte recruitment, and proinflammatory cytokine and chemokine expression. Neither autoantibody production nor T and B cell activation were significantly affected, pointing to the specificity of MIF antagonism in reducing excessive proinflammatory responses. These data highlight the feasibility of targeting the MIF-MIF receptor interaction by small-molecule antagonism and support the therapeutic value of downregulating MIF-dependent pathways of tissue damage in systemic lupus erythematosus.
Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light (1998)

The induction of apoptosis from different intracellular sites was studied by exposing V79 Chinese hamster fibroblasts to photodynamic therapy (PDT) with various porphyrins and light. The effects of two lipophilic, intracellular membrane-localized porphyrins, tetra(3-hydroxyphenyl)porphyrin (3THPP) and Photofrin, were compared with that of two sulphonated meso-tetraphenylporphines (TPPS2a and TPPS4), which are taken up into lysosomes by endocytosis. Apoptotic fractions induced by the various dyes and light were quantified by flow cytometry using the terminal deoxynucleotidyl transferase (TdT) assay. Cell fragmentation was measured in parallel, while the nuclear morphology of apoptotic cells was studied by fluorescence microscopy. Different kinetics were found for the induction of DNA strand breaks characteristic of apoptotic cells. PDT-induced damage to membranes resulted in an increasing number of apoptotic cells for about 12 h after PDT After damage to lysosomes, apoptotic cells were not detected until more than 12 h after PDT. Furthermore, apoptotic bodies were not observed after PDT-induced damage to intracellular membranes, whereas apoptosis induced from lysosomal sites was characterized by extensive cell fragmentation. Cell fragmentation occurred in combination with or in the absence of nuclear fragmentation. The results support the idea that the degradation phase of apoptosis can consist of a sequence of independent steps rather than a common final pathway.
Novel Tetralone-Derived Retinoic Acid Metabolism Blocking Agents:  Synthesis and in Vitro Evaluation with Liver Microsomal and MCF-7 CYP26A1 Cell Assays (2005)

The potent inhibitory activity of novel 2-benzyltetralone and 2-benzylidenetetralone derivatives vs liver microsomal retinoic acid metabolizing enzymes and a MCF-7 CYP26A1 cell assay is described. In the liver microsomal assay, the 2-biphenylmethyl-6-hydroxytetralone derivatives 16a and 16b were found to be potent inhibitors (IC50 = 0.5 and 0.8 microM) compared with the broad spectrum P450 inhibitor ketoconazole and the retinoid mimetic R115866 (IC50 = 18.0 and 9.0 microM, respectively). In the MCF-7 CYP26A1 cell assay, the 2-(4-hydroxybenzyl)-6-methoxytetralone 5 and unsaturated benzylidene precursor 6 were found to be the most potent (IC50 = 7 and 5 microM, respectively), which was comparable with liarozole (7 microM) but considerably less active than R115866 (IC50 = 5 nM). With a CYP26A1 homology model, the tetralones were shown to be positioned in a hydrophobic tunnel with additional interactions, e.g., transition metal coordination and hydrogen-bonding interactions with GLY300, observed for the potent 4-hydroxyphenyl substituted inhibitors.
Lipid Binding of Apolipoprotein CII Is Required for Stimulation of Lipoprotein Lipase Activity Against Apolipoprotein CII–Deficient Chylomicrons (1997)

Human apolipoprotein CII (apo CII) consists of 79 amino acid residues. The amino-terminal two thirds of the molecule binds to lipid through the formation of amphipathic helixes, while the carboxy-terminal third is engaged in activation of lipoprotein lipase (LPL). On the basis of studies in model systems, it was previously concluded that fragments of apo CII spanning residues 51-79 were sufficient for activation, although they do not bind to lipid. In the present study, we used chylomicrons from an apo CII-deficient patient to reinvestigate this possibility, with a physiologically relevant substrate. Human LPL expressed very low activity against these chylomicrons. Addition of apo CII caused an immediate > 100-fold increase in lipase activity. The apo CII fragment 50-79 caused very little stimulation, though with some synthetic lipid substrates, this fragment was fully effective. LPL bound to the chylomicrons even in the absence of apo CII but apparently in a nonproductive manner. In accord with this finding, the main effect of apo CII was on the VMAX for the reaction, with little or no change in the apparent K(M). We conclude that the lipid-binding part of apo CII is needed for activity of LPL against chylomicrons. This idea is in accord with previous studies with lipid monolayers, which showed that the lipid-binding part is necessary for activation of the enzyme at high surface pressures.
Hierarchical Nested-Network Nanostructure by Dealloying (2013)

Applications of porous microstructures in functional materials often impose conflicting requirements on the pore size, which may be met by hierarchical structures that combine porosity on distinctly different length scales. Here we report an electrochemical dealloying strategy that yields bulk samples of porous gold with a hierarchical microstructure. A nanoscale network of solid ligaments forms the lower hierarchy level, which is nested within the geometrically similar, but much larger, network of the upper hierarchy level. Starting from a dilute solid solution of Au in Ag, controlled electrochemical corrosion yields nanoporous Ag-Au alloy as an intermediate product. Coarsening of the porous alloy creates the large ligaments of the upper hierarchy level. Those are then again dealloyed, which creates the fine ligaments of the lower hierarchy level. We show that the material exhibits enhanced charge transport kinetics while maintaining a large specific surface area.
The Wheatstone bridge as an alignment test structure (2002)

A new test structure for the electrical measurement of level-to-level registration is introduced. This structure, based on the Wheatstone bridge measurement principle, offers improved accuracy over the conventional U-shaped test structure. With the described Wheatstone bridge method, the registration error (misalignment) is directly proportional to a single voltage. In contrast, the misalignment of the U-shaped structure is calculated from the difference of two voltages, an operation that can result in poor precision. The paper describes a two-by-twelve contact pad module, which includes two Wheatstone bridge structures to measure the misalignment in the X- and Y-directions, two calibration structures to determine the zero- and full-scale accuracy, and a Van der Pauw structure to measure the sheet resistance of the conducting material as required for the alignment measurement. The mathematical expressions are derived, and actual test results are discussed.
Anti-inflammatory Effects of Resveratrol and Its Potential Use in Therapy of Immune-mediated Diseases (2012)

A molecule with a relatively simple chemical structure, resveratrol has been found to interact with multiple molecular targets, many of them associated with inflammation and immunity. Indeed, it has been shown to act directly on central players of both innate and adaptive immunity, such as macrophages, lymphocytes, and dendritic cells. In addition, there is very little evidence suggesting significant deleterious side effects of resveratrol, further highlighting its potential future use as a therapeutic agent. This review provides an up-to-date discussion on recent advances regarding anti-inflammatory effects of resveratrol, mechanisms of action, and its potential for therapeutic use.
Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia (2016)

Hypoxia in the tumor microenvironment (TME) mediates resistance to radiotherapy and contributes to poor prognosis in patients receiving radiotherapy. Here we report the design of clinically suitable formulations of hybrid manganese dioxide (MnO<sub>2</sub>) nanoparticles (MDNP) using biocompatible materials to reoxygenate the TME by reacting with endogenous H<sub>2</sub>O<sub>2</sub> MDNP containing hydrophilic terpolymer-protein-MnO<sub>2</sub> or hydrophobic polymer-lipid-MnO<sub>2</sub> provided different oxygen generation rates in the TME relevant to different clinical settings. In highly hypoxic murine or human xenograft breast tumor models, we found that administering either MDNP formulation before radiotherapy modulated tumor hypoxia and increased radiotherapy efficacy, acting to reduce tumor growth, VEGF expression, and vascular density. MDNP treatment also increased apoptosis and DNA double strand breaks, increasing median host survival 3- to 5-fold. Notably, in the murine model, approximately 40% of tumor-bearing mice were tumor-free after a single treatment with MDNPs plus radiotherapy at a 2.5-fold lower dose than required to achieve the same curative treatment without MDNPs. Overall, our findings offer a preclinical proof of concept for the use of MDNP formulations as effective radiotherapy adjuvants. Cancer Res; 76(22); 6643-56. ©2016 AACR.
Ultra-low on-resistance LDMOS implementation in 0.13&#x00B5;m CD and BiCD process technologies for analog power IC's (2009)

Toshiba's 5th generation BiCD/CD-0.13 is a new process platform for analog power applications based on 0.13µm CMOS technology. The process platform has six varieties of rated voltage, 5V, 6V, 18V, 25V, 40V, and 60V. 5 to 18V CD-0.13 process use P-type silicon substrate. 25 to 60V BiCD-0.13 process use N-Epi wafer with N+/P+ buried layer on P type silicon substrate. Each LDMOS recode ultra-low on-resistance compared with that of previous papers, and we will realize the highest performance analog power IC's using this technology.
The Cardioprotective Protein Apolipoprotein A1 Promotes Potent Anti-tumorigenic Effects (2013)

Here, we show that apolipoprotein A1 (apoA1), the major protein component of high density lipoprotein (HDL), through both innate and adaptive immune processes, potently suppresses tumor growth and metastasis in multiple animal tumor models, including the aggressive B16F10L murine malignant melanoma model. Mice expressing the human apoA1 transgene (A1Tg) exhibited increased infiltration of CD11b(+) F4/80(+) macrophages with M1, anti-tumor phenotype, reduced tumor burden and metastasis, and enhanced survival. In contrast, apoA1-deficient (A1KO) mice showed markedly heightened tumor growth and reduced survival. Injection of human apoA1 into A1KO mice inoculated with tumor cells remarkably reduced both tumor growth and metastasis, enhanced survival, and promoted regression of both tumor and metastasis burden when administered following palpable tumor formation and metastasis development. Studies with apolipoprotein A2 revealed the anti-cancer therapeutic effect was specific to apoA1. In vitro studies ruled out substantial direct suppressive effects by apoA1 or HDL on tumor cells. Animal models defective in different aspects of immunity revealed both innate and adaptive arms of immunity contribute to complete apoA1 anti-tumor activity. This study reveals a potent immunomodulatory role for apoA1 in the tumor microenvironment, altering tumor-associated macrophages from a pro-tumor M2 to an anti-tumor M1 phenotype. Use of apoA1 to redirect in vivo elicited tumor-infiltrating macrophages toward tumor rejection may hold benefit as a potential cancer therapeutic.
Evaluation of Biodegradable Polyesters Modified by Type II Collagen and Arg‐Gly‐Asp as Tissue Engineering Scaffolding Materials for Cartilage Regeneration (2005)

Synthetic biodegradable polyesters poly(L-lactide) (PLLA) and poly(D,L-lactide-coglycolide) (PLGA) (50:50) modified by porcine type II collagen and an Arg-Gly-Asp (RGD)-containing protein were evaluated as scaffolds for cartilage regeneration in this study. Cytocompatibility of the polymer films was tested using immortalized chondrocytes. Neocartilage formation in vitro on cell-seeded scaffolds was further examined using primary porcine chondrocytes. The inflammatory response of the scaffolds was evaluated subcutaneously in rats. A pilot animal study was conducted, in which rabbit allogeneic chondrocyte-seeded scaffolds were implanted to repair the defected rabbit knee cartilage. The results demonstrated that PLGA as well as its blends with PLLA had better cell growth than pure PLLA, and that type II collagen enhanced, but RGD inhibited cell proliferation. Scaffolds made of blended PLLA/PLGA had larger dynamic compressive modulus compared to scaffolds made of PLLA or PLGA single polymer. Chondrocyte-seeded scaffolds modified by type II collagen without RGD had the greater number of cells as well as higher glycosaminoglycan (GAG) and collagen contents compared to scaffolds without type II collagen modification or scaffolds further modified with RDG. Type II collagen modification prevented infiltration by host tissue and capsule formation. Unmodified PLLA and PLLA/PLGA constructs demonstrated persisting inflammatory response after 6 months, while all type II collagen-modified PLLA/PLGA constructs showed complete repair and no inflammation. Partial or full repair was observed after 2 months of postimplantation in type II collagen-modified PLLA/PLGA constructs, with equal cellularity and 75-80% matrix contents of a normal rabbit articular cartilage. It was concluded that PLLA/PLGA blended scaffolds modified by type II collagen were a potential tissue engineering scaffold for cartilage regeneration.
A New Tandem Sigmatropic Rearrangement/Michael Addition Sequence for the Construction of Highly Substituted Benzofurans (1992)

A general route to substituted benzofurans 1 starting from substituted 2-hydroxybenzaldehydes 4 utilising a tandem 2,3-sigmatropic rearrangement/Michael addition sequence is reported.
Provable defenses against adversarial examples via the convex outer adversarial polytope (2017)

We propose a method to learn deep ReLU-based classifiers that are provably robust against norm-bounded adversarial perturbations on the training data. For previously unseen examples, the approach is guaranteed to detect all adversarial examples, though it may flag some non-adversarial examples as well. The basic idea is to consider a convex outer approximation of the set of activations reachable through a norm-bounded perturbation, and we develop a robust optimization procedure that minimizes the worst case loss over this outer region (via a linear program). Crucially, we show that the dual problem to this linear program can be represented itself as a deep network similar to the backpropagation network, leading to very efficient optimization approaches that produce guaranteed bounds on the robust loss. The end result is that by executing a few more forward and backward passes through a slightly modified version of the original network (though possibly with much larger batch sizes), we can learn a classifier that is provably robust to any norm-bounded adversarial attack. We illustrate the approach on a number of tasks to train classifiers with robust adversarial guarantees (e.g. for MNIST, we produce a convolutional classifier that provably has less than 5.8% test error for any adversarial attack with bounded $\ell_\infty$ norm less than $\epsilon = 0.1$), and code for all experiments in the paper is available at this https URL.
Akkusativobjekt, Akkusativobjektsätze und Objektsprädikate im Deutschen: Untersuchungen zu ihrer Syntax und Semantik. Karin Bausewein. Linguistische Arbeiten, 251. Tübingen: Max Niemeyer, 1990. Pp. viii + 273. (1993)

Akkusativobjekt, Akkusativobjektsätze und Objektsprädikate im Deutschen: Untersuchungen zu ihrer Syntax und Semantik. Karin Bausewein. Linguistische Arbeiten, 251. Tübingen: Max Niemeyer, 1990. Pp. viii + 273. - Volume 5 Issue 1
Methods for the study of transverse momentum differential correlations (2009)

We introduce and compare three differential correlation functions for the study of transverse-momentum correlations in $p+p$ and $A+A$ collisions. These consist of inclusive and eventwise and a differential version of the correlation measure $\stackrel{~}{C}$ introduced by Gavin [1] for experimental study of the viscosity per unit entropy of the matter produced in $A+A$ collisions. We study the quantitative difference between the three observables on the basis of PYTHIA simulations of $p+p$ collisions and $A+A$ collisions consisting of an arbitrary superposition of $p+p$ collision events at $\sqrt{s}=200$ GeV. We observe that inclusive and eventwise correlation functions are remarkably similar to each other whereas the observable $\stackrel{~}{C}$ differs quantitatively from the two. We study the robustness and efficiency dependencies of these observables based on truncated Taylor expansions in efficiency in $p+p$ collisions and on the basis of Monte Carlo simulation using an ad hoc detector efficiency parametrization. We find that all the three observables are essentially independent of detector efficiency. We additionally study the scaling of the correlation measures and find all the observables exhibit an approximate $1/N$ dependence of the number of participants $(N)$ in $A+A$ collisions. Finally, we study the impact of flowlike anisotropy on the inclusive correlation function and find flow imparts azimuthal modulations similar to those observed with two-particle densities.
[Species identification of biological samples by amplifying intron 8 of the TP53 gene]. (2005)

The method of species identification by amplifying intron 8 of the TP53 gene is simple and sensitive.
Production of Olefins and Higher Hydrocarbons by Thermal Coupling of Methane (1992)

Thermal coupling of methane or methane pyrolysis, which is a possible way for the direct chemical conversion of natural gas, can be used to produce ethylene, acetylene and benzene. But the high stability of methane requires a very high pyrolysis temperature (1200°C). To perform this reaction, IFP decided to build and elecric pilot furnace with an overall capacity of 10 m3/h. The design of this furnace is based on shell-and-tube heat exchanger technology with the use of new materials such as ceramics. This furnace has now been operating for more than one year without any noteworthy incident. First we will describe the technological and parametric study that has now been completed. In conclusion, we will make a short economic assessment of the production of ethylene and acetylene in France.
Construction and Applications of a Microcomputer Controlled Pulsed Amperometric Detector System (1986)

ABSTRACT The construction of a microcomputer controlled pulsed amperometric detector system is described. It includes a potentiostat, a flow-through cell and a sample injection unit. The microcomputer generates the appropriate waveform of the applied potential and controls the overall sequence of the measurement. The system is suitable for general studies on the detection of various classes of organic compounds with the pulsed amperometric technique. The detectability of various hydroxycompounds has been studied.
An absolute charge sensor of fluid electrification measurements (1991)

A new instrument, the Absolute Charge Sensor (ACS), has been developed that measures the net charge density entrained in a fluid flow, independent of the fluid's electrical properties, velocity, and any electrification processes within the instrument. Through a shielded sampling probe, the ACS periodically transfers a small volume of charged fluid to an electrically isolated Faraday cage with no fluid exiting. The charge density is calculated from the known filling flow rate and either the current or voltage, respectively measured by low or high impedance electrometers connected to the electrically isolated Faraday cage. The ACS overcomes the ambiguity in current or voltage measurements of probes placed into the fluid flow where it is impossible to separate contributions from impacting charge in the flow from charge separated at the probe interface by the very charge generation and transport processes that are under study. The instrument is typically operated to measure charge densities as low as a few mu C/m/sup 3/ using a sampling flow rate of 0.18 cm/sup 3/ with a sampling period on the order of 1 min. A Couette charger apparatus that simulates flow electrification processes in transformers and fuel pumps has been used to test the ACS using transformer oil or gasoline. Result show good correlation between the ACS and continuous flow measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An operational HF system for single site localization (2006)

This paper presents an operational HF (3–30MHz) system designed for single site localization (SSL). An original version of the MUSIC algorithm jointly estimates the angles of arrival (azimuth and elevation) of incident waves and their polarization.
The risk of atrial fibrillation during right ventricular pacing (2015)

HA pacing compared with RVA or RVS pacing seems to be associated with a lower risk of persistent/permanent AF occurrence. The risk of persistent/permanent AF was similar in the RVA vs. RVS groups.
Sill-Controlled Flow Transitions and Extent of Erosion (1970)

The distance is determined over which scour will develop downstream of a sill-controlled flow transition in an erodible open channel, in which the sediment motion is impending. This determination is based on the concept of dynamic similarity that makes it possible to relate the erosion length in an erodible channel to the total length of flow transition in a fixed-bed channel. Accordingly, prediction of the limiting extent of erosion becomes possible for a wide variety of sill-controlled flow transitions, including the cases present in the hydraulic jump stilling basins, and the natural hydraulic jump.