gebhart/patrepeval huggingface dataset:
Detection and Quantification of Mycoplasma genitalium in Male Patients with Urethritis (2003)

Detection and quantification of Mycoplasma genitalium were evaluated in 83 patients with urethritis (group 1), 60 patients with urethral symptoms but no urethritis (group 2), and 50 asymptomatic men (group 3). Quantification of M. genitalium was carried out using real-time polymerase chain reaction (PCR) analysis of first-pass urine samples. The rate of detection of M. genitalium was significantly higher in group 1 than in groups 2 and 3 (P<.0001). The mean observed concentration of M. genitalium was 1.2x10(4) equivalent genomes/mL of urine (range, 50 to 8x10(4) equivalent genomes/mL). Analysis of M. genitalium load in serial urine samples collected before and after the administration of antibacterial treatment showed an association between clinical and microbiological responses, with a shift to negative PCR results in symptom-free patients. Our results illustrate the usefulness of monitoring the M. genitalium load in evaluating the susceptibility of M. genitalium to antibacterial treatment.
Hemodynamic Effects of Intraaortic Versus Intravenous Protamine Administration after Cardiopulmonary Bypass in Man (1992)

A hemodynamic study of men undergoing elective coronary artery bypass surgery was undertaken to elucidate the side effects of protamine given into the ascending aorta (group A, n = 16) or into the central venous line (group V, n = 16). After termination of extracorporeal circulation, protamine was infused over 120 seconds, and the hemodynamic profile was continuously recorded. During the first minute, the systemic arterial pressure fell to about 60% of the preprotamine level in both groups, but the hemodynamic changes occurred more rapidly (p < 0.05) in group V than in group A, with maximal pressure drop at 61.7 +/- 2.7 vs 74.4 +/- 4.9 seconds. Following spontaneous restoration of the systemic blood pressure, the pulmonary artery pressure rose considerably in both groups, as did the pulmonary capillary wedge and central venous pressures, reaching higher levels in the intravenous group. The cardiovascular responses were again more rapid in group V than in group A (p = 0.004). The degree of systemic hypotension thus did not benefit from use of the intraaortic rather than the intravenous route for administering protamine. The more pronounced and more rapid pulmonary circulatory changes in the intravenous group suggest that the hemodynamic effects of protamine are initiated in the lungs.
Pandemic influenza A (H1N1) 2009: the experience of the first six months (2009)

After a break of 41 years, 2009 saw the first influenza pandemic of the 21st century caused by a triple-reassortant influenza A (H1N1) virus. The current estimated case fatality rate is lower than that of previous influenza pandemics, but this may change as the pandemic evolves. Illness frequently occurs in previously healthy, young adults with a wide range of clinical presentations. The majority of circulating pandemic viruses remain susceptible to neuraminidase inhibitors, although all strains are intrinsically resistant to the adamantanes. Monovalent vaccines against the pandemic strain are available in both live attenuated and inactivated forms. This review aims to summarise important virological, epidemiological and clinical aspects of the pandemic influenza A (H1N1) virus for physicians and other clinical personnel.
Anti-tumoral Effects of Recombinant Lactococcus lactis Strain Secreting IL-17A Cytokine (2019)

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine produced by T<sub>H17</sub> cells that participates and contributes in host defense and autoimmune disease. We have recently reported antitumor properties of the probiotic strain of <i>Lactobacillus casei</i> BL23 in mice and T<sub>H17</sub> cells was shown to play an important role in this beneficial effect. In order to better understand the role of IL-17A in cancer, we constructed a recombinant strain of <i>Lactococcus lactis</i> producing this cytokine and we determined its biological activity in: (i) a bioassay test for the induction of IL-6 production by murine fibroblasts 3T3 L1 cells line and (ii) in a mouse allograft model of human papilloma virus (HPV)-induced cancer. Our data show that recombinant <i>L. lactis</i> produces and efficiently secretes biologically active IL-17A cytokine. Interestingly, ∼26% of mice intranasally treated with <i>L. lactis</i>-IL-17A and challenged with TC-1 cells remained tumor free over the experiment, in contrast to control mice treated with the wild type strain of <i>L. lactis</i> which developed 100% of aggressive tumors. In addition, the median size of the ∼74% tumor-bearing mice treated with recombinant <i>L. lactis</i>-IL-17A, was significantly lower than mice treated with <i>L. lactis</i>-wt. Altogether, our results demonstrate that intranasal administration with <i>L. lactis</i> secreting IL-17A results in a partial protection against TC-1-induced tumors in mice, confirming antitumor effects of this cytokine in our cancer model.
Down regulation of IL 2 mRNA by antibody to the 50-kd protein associated with E receptors on human T lymphocyte. (1986)

Recent studies have shown that antibodies to certain epitopes on the 50-kd molecule associated with sheep erythrocyte receptors on human T cells can suppress T cell proliferation and interleukin 2 (IL 2) elaboration. We used a human IL 2 cDNA clone to investigate the effect of antibody 9.6 and cyclosporin A (CsA) on the regulation of IL 2 mRNA levels in the cloned human leukemic T cell line Jurkat, J32. Maximal levels of IL 2 mRNA were reached 6 hr after induction of Jurkat cells with a combination of mitogen phytohemagglutinin (PHA) and phorbol ester (TPA). Antibody 9.6, added during the first 4 hr after lymphocyte stimulation, markedly inhibited IL 2 mRNA accumulation induced by low but synergistic combination of PHA (5 micrograms/ml) and TPA (1.0 ng/ml). The inhibition by 9.6 was not demonstrable as the concentration of PHA or TPA was increased. In contrast, the ability of CsA to suppress IL 2 mRNA accumulation appeared to be independent of PHA or TPA concentration and was minimal if CsA was added 4 hr after stimulation. IL 2 mRNA could be superinduced several folds by addition of cycloheximide 3 hr after induction of J32 with mitogens. Antibody 9.6 did not prevent IL 2 mRNA superinduction induced by cycloheximide, whereas CsA, as well as transcription inhibitor DRB, completely blocked this phenomenon. These findings indicate that signals induced by antibody 9.6 regulate IL 2 production at a pre-translational level, are operative for an extended period of time overlapping with the early phase of IL 2 mRNA accumulation, suppress IL 2 gene expression induced by PHA as well as TPA, and that antibody 9.6 and CsA exert their inhibitory effect by distinct mechanism(s).
VEHICLE TRAVEL TIME DISTRIBUTION ESTIMATION AND MAP-MATCHING VIA MARKOV CHAIN MONTE CARLO METHODS (2013)

We introduce two statistical methods for estimating vehicle travel time distributions on a road network, using Global Positioning System (GPS) data recorded during historical vehicle trips. In the first method, we use a model of the path taken by each vehicle in the data, the travel time on each road segment in the network, and the location and speed errors for each GPS observation. In the second method, we use a model of the entire travel time of each trip, and include covariates such as the types of roads traveled and time of day. We estimate the parameters of both models by Markov chain Monte Carlo methods. We compare the performance of these methods with two simpler methods, a recently published method, and commercially available travel time estimates, using data from ambulance trips in Toronto and simulated data. Our methods outperform the alternative methods in point and distribution estimation of outof-sample trip travel times. Our methods also provide more realistic estimates than the recently published method of the probability that an ambulance is able to respond to each intersection in Toronto within a time threshold. We also consider map-matching, i.e. estimating a vehicle's path from sparse and error-prone GPS data, which is an important sub-problem for travel time estimation. In practice, successive GPS location readings are frequently biased in the same direction. We introduce a statistical map-matching method that takes into account bias in GPS locations, leading to improved accuracy.
Design of hierarchical zeolite catalysts by desilication (2011)

Hierarchical (or mesoporous) zeolites have received an ever-increasing attention due to their improved performance in catalysed reactions with respect to conventional (purely microporous) zeolites. Desilication in alkaline media has become a widely applied preparation method to tailor these modified zeolites, due to an optimal combination of efficiency and simplicity. This review presents recent developments that have expanded its general understanding and turned this top-down treatment highly versatile, controllable, and scalable. Design aspects of mesoporous zeolites for catalytic applications are emphasised, encircling the establishment of synthesis–property–function relationships. Alkaline treatment is a key step in strategic combinations with other post-synthesis modifications towards superior zeolite catalysts. The outlook of the field, pinpointing present needs and short-term priorities, is discussed.
OFDM-CDMA versus DS-CDMA: performance evaluation for fading channels (2002)

In code division multiple access (CDMA) systems direct sequence (DS) applying maximum ratio combining (MRC) at the receiver has achieved high interest for mobile communications. A second and rather novel technique is orthogonal frequency division multiplexing (OFDM) applying maximum-likelihood detection (MLD) at the receiver. In this paper the performance of both techniques is compared considering the mobile radio environment. The analytical results for both DS-CDMA and OFDM-CDMA are confirmed by Monte Carlo simulations. The analysis enables a performance comparison between the DS-CDMA system and the OFDM-CDMA system with respect to the demands of low complexity receivers which is important for system design. The results show that OFDM-CDMA outperforms DS-CDMA in terms of spectral efficiency.
Design of a brushless doubly-fed induction motor for adjustable speed drive applications (2002)

The paper begins with a delineation of historical evolution of the brushless doubly-fed induction motor (BDFIM) concept. A methodology for the steady-state performance analysis and design of the BDFIM is then given, following a descriptive review of the operating principles and dynamic controls of the BDFIM. A 10 hp brushless doubly-fed induction motor has been designed for comparison with a squirrel-cage induction motor, and a cost comparison is made between the brushless doubly-fed induction motor drive and the baseline squirrel-cage induction motor drive, showing some 30% total system cost savings despite of a cost differential incurred on the BDFIM. A brief discussion of the ramification of potential applications of this new motor technology is also included, with the most promising niche markets identified as variable speed industrial pumps (fans), variable speed constant frequency (VSCF) wind/hydro power generators, high speed traction or spindle drives requiring wide field-weakening ranges and brushless operation.
Time-Varying Myocardial Stress and Systolic Pressure-Stress Relationship (2009)

Peak myocardial stress occurs in early systole, before important contributions of reflected waves to central pressure. In the presence of normal LV ejection fraction, a midsystolic shift in the pressure-stress relationship protects cardiomyocytes against excessive late systolic stress (despite pressure augmentation associated with wave reflections), a coupling mechanism that may be altered in various disease states.
Overexpression and Structural Study of the Cathelicidin Motif of the Protegrin-3 Precursor (2001)

Numerous precursors of antibacterial peptides with unrelated sequences share a similar prosequence of 96-101 residues, referred to as the cathelicidin motif. The structure of this widespread motif has not yet been reported. The cathelicidin motif of protegrin-3 (ProS) was overexpressed in Escherichia coli as a His-tagged protein to facilitate its purification. The His tag was then removed by thrombin cleavage. In addition, the complete proprotegrin-3 (ProS-PG-3) (120 residues) was overexpressed in baculovirus-infected insect cells. As it contained the antibacterial peptide protegrin-3 in its C-terminal part, ProS-PG-3 contained four disulfide bonds. At neutral pH, ProS and ProS-PG-3 adopted two slowly exchanging conformations that existed in a ratio of 55/45. This ratio was progressively modified at acidic pH to reach a 90/10 value at pH 3.0, suggesting that electrostatic interactions are involved in such a conformational change. Therefore, the structural study of the main conformer was undertaken at pH 3.0 by circular dichroism, mass spectrometry, and homo- and heteronuclear NMR. In parallel, a model for the ProS structure was built from the X-ray structure of the chicken cystatin. ProS and the chicken cystatin share two conserved disulfide bonds as well as a high conservation of hydrophobic residues. The ProS model features the conservation of a hydrophobic core made of the interface between the N-terminal helix and the wrapping beta-sheet. Although the full assignment of the main conformer of ProS could not be obtained, available NMR data validated the presence of the N-terminal helix and of a four-stranded beta-sheet, in agreement with the cystatin fold. Moreover, we clearly demonstrated that ProS and ProS-PG-3 share the same global structure, suggesting that the presence of the highly constrained beta-hairpin of protegrin does not significantly modify the structure of the cathelicidin motif of the protegrin precursor.
A high performance CMOS technology for 256K/1MB EPROMs (1985)

A technology has been developed which integrates new pro cesses necessary to implement high performance and reliable CMOS EPROMS. This technology consists of a single 250 A first poly transistor with double diffused source and drains utilized both for high voltage circuitry (L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</inf> = 2.2 um) as well as peripheral circuits (L <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">eff</inf> = 1.2 um). Furthermore, a thin oxide-nitride -oxide (ONO) interpoly dielectric for reliable floating gate performance is incorporated. Good dielectric breakdown, defect density, and charge retention characteristics are obtained. Write characteristics as well as softwrite endurance have been measured to be compatible with current high density EPROM designs.
Simultaneous Raman and Fluorescence Spectroscopy of Single Conjugated Polymer Chains (2007)

Simultaneous surface enhanced Raman scattering (SERS) and fluorescence is demonstrated from single conjugated polymer chains. As resonance enhancement of SERS depends on the spectral overlap of the polymer's absorption and the incident laser, resonance Raman and fluorescence effectively probe the absorbing and emitting part of the polymer, respectively. The optical phonon energies change along the polymer chain, providing a window to spatially track excited state relaxation. Whereas a mean spatial redistribution of the excitation is witnessed by a change in vibronic fingerprint following interchromophoric energy transfer, intrachromophoric exciton self-trapping leaves the vibrations unchanged.
Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples (2003)

Accurate genetic testing for polymorphisms in several genes of pharmacogenetic importance can be obtained from archival paraffin-embedded tumor samples. Thus, pharmacogenetic analysis can be applied to existing cancer therapy trials to test associations between these polymorphisms and treatment response.
278. Tuberculostatic hydrazides and their derivatives (1953)

Ng. Ph. Buu-Hoï, Ng. D. Xuong, Ng. H. Nam, F. Binon and R. Royer, J. Chem. Soc., 1953, 1358 DOI: 10.1039/JR9530001358
Analysis, simulation and circuit implementation of a precise high-output impedance analog current mirror (2010)

The decision for most the appropriate current mirror topology when designing a circuit is a matter of trade-offs between impedance, current transfer ratio, area on chip, power consumption and voltage-headroom, expandability etc. Current mirrors are mainly used for biasing, for transferring current from one part of the circuit to another or as load for amplifier stages. This paper presents the theoretical analysis, the simulation and the circuit built of a current mirror with excellent performance characteristics compared to conventional designs at the expense of voltage-headroom. Great emphasis in the analysis of the circuit has been paid on the current transfer ratio and the output impedance of the configuration.
Development of a synchronous motor with Gd–Ba–Cu–O bulk superconductors as pole-field magnets for propulsion system (2006)

Rotating machines with high-temperature superconductors (HTS) usually consist of pole-field magnets having coils wound with Bi-2223 HTS wire. We have successfully used Gd–Ba–Cu–O bulk HTS in pole-field magnets in an axial-gap type rotating machine. These HTS pole-field bulk magnets were assembled in the rotor plate. They are cooled down with a liquid cryogen supplied via a rotary joint and circulated inside the rotor plate. The present design provides a small air gap and a bulk HTS gives a high magnetic field around the armature coils. Successful mechanical design has enabled us to magnetize the pole-field bulk to more than 1 T by using a pulsed current applied to the copper armature coils. These techniques imply the possibility of smaller and lighter rotating motors or generators with a HTS bulk magnet for a sub-megawatt class propulsion system. We report several essential techniques for both mechanical and cryogenic designs, and deduce the characteristic features of the present axial-gap type machine using a HTS bulk magnet.
Traffic Light Recognition and Ranging System Based on Machine Vision (2019)

The process of traffic information has become an important aspect of automated driving nowadays. Thus, in this paper a small mobile system is proposed, in which MobileNetV2+SSD model is deployed and combined with binocular stereo-vision ranging to realize the recognition and ranging of traffic lights. Experiment results with real images show that this system can effectively process the information of traffic lights under real road conditions.
Evaluation of proliferative markers in canine mammary tumours (2008)

The present investigation was carried out with an aim to study the different proliferative cell markers in spontaneous canine mammary tumours. Out of 67 suspected tumours cases, 63 were histopathologically confirmed as tumours with higher occurrence of malignant (50) than benign tumours (13). Benign tumours were identified as cystic fibroadenoma (7), benign mixed mammary tumour (3), papillary adenoma (2) and myoepithelioma (1). The malignant mammary tumours were malignant mixed mammary tumour (13), papillary adenocarcinoma (12), adenocarcinoma (10), solid carcinomas (8) and malignant myoepithelioma (7). There was significant difference in different proliferative markers, argyrophilic nucleolar organizer region (AgNOR), proliferative cell nuclear antigen (PCNA) and proliferative cell nuclear protein Ki-67 (Ki-67) indices between benign and malignant tumours except in mitotic index. There was also significant correlation between AgNOR, PCNA and Ki-67 indices (P<0.01) with Ki-67 index being highly sensitive than PCNA in differentiating and determining the proliferation rate of malignant and benign tumours.
Tolerability of Amine Uptake Inhibitors in Urologic Diseases (2006)

Inhibitors of serotonin (5-HT) and/or noradrenaline (NA) reuptake have been developed for pharmacological treatment of major depressive disorder. Insights in the role of 5-HT and NA in the neurological control of the lower urinary tract have also led to their application in common urological conditions such as stress urinary incontinence (SUI), nocturnal enuresis and ejaculatory disorders. The European approval of the 5-HT and NA reuptake inhibitor (SNRI) duloxetine for treatment of SUI underlines the importance of a new approach in SUI, but has also given rise to questions about the safety of antidepressants in urology. This paper reviews the safety of 5-HT and NA reuptake inhibitors in their on- and off-label use in urology. A systematic Medline search was performed for randomised controlled trials, meta-analyses and practice guidelines dealing with antidepressants in urology. The safety profiles of the drugs in the urological population were compared with data from psychiatric populations. Tricyclic antidepressants are associated with serious cardiovascular side effects. In addition, anticholinergic and antihistaminic side effects are common. Although recently questions have been raised regarding the cardiovascular safety profile of venlafaxine, most selective 5-HT reuptake inhibitors and SNRI have not been associated with serious cardiovascular effects. Their most common side effect is nausea. However, nausea tends to be mild and, importantly, transient. Patient counselling about side effects and up-titrating doses may be useful strategies for minimising discomfort and withdrawals.
Microbiology of Acute Otitis Media with Tympanostomy Tubes (2005)

The study demonstrates that AOMT is frequently caused by organisms not susceptible to oral antibiotics approved for children, but which are sensitive to topical ear drops.
Low Offset, Low Noise, Variable Gain Interfacing Circuit with a Novel Scheme for Sensor Sensitivity and Offset Compensation for MEMS Based, Wheatstone Bridge Type, Resistive Smart Sensor (2011)

A fully-analog, on-chip, low input offset, low noise, variable gain instrumentation amplifier with a new scheme for nonlinear and dynamic temperature compensation of sensor sensitivity and offset, is designed in 0.18μm commercial CMOS process. The system has a scalable system bandwidth up to 5kHz, a dynamic range of 84dB, and a maximum gain of 104dB. All the sensor non idealities and CMOS process mismatch have been incorporated in simulation. Using this interfacing circuit, a smart MEMS piezoresistive accelerometer has been designed subsequently.
Quantitative relationship between yeasts and bacteria in denture‐induced stomatitis (1983)

Quantitative cultural studies of yeasts and bacteria were made from 7-day-old denture plaque accumulate on pieces of self-adhesive tape stuck on the fitting surface of the maxillary denture in 17 edentulous subjects with healthy oral mucosa and in 27 patients affected with denture-induced stomatitis. Significantly higher numbers of yeasts and bacteria were cultured in the stomatitis patients than in the controls. This indicates that the rate of plaque formation is increased in patients with denture-induced stomatitis. Yeasts usually constituted less than 1% of the anaerobic bacterial counts, but the percentage of yeasts was significantly higher in the stomatitis patients than in the controls. There was a significant correlation between initially higher yeast counts and improvement of the clinical condition of the palatal mucosa following antimycotic treatment. In some patients only bacteria were grown and antimycotic treatment had no effect. The study supported the contention that yeast antigens and toxins of denture plaque are significant factors in initiation and maintenance of denture-induced stomatitis. However, bacteria may also be involved as pathogens.