gebhart/patrepeval huggingface dataset:
Non-Invasive Detection of Protein Content in Several Types of Plant Feed Materials Using a Hybrid Near Infrared Spectroscopy Model (2016)

Near-infrared spectroscopy combined with chemometrics was applied to construct a hybrid model for the non-invasive detection of protein content in different types of plant feed materials. In total, 829 samples of plant feed materials, which included corn distillers' dried grains with solubles (DDGS), corn germ meal, corn gluten meal, distillers' dried grains (DDG) and rapeseed meal, were collected from markets in China. Based on the different preprocessed spectral data, specific models for each type of plant feed material and a hybrid model for all the materials were built. Performances of specific model and hybrid model constructed with full spectrum (full spectrum model) and selected wavenumbers with VIP (variable importance in the projection) scores value bigger than 1.00 (VIP scores model) were also compared. The best spectral preprocessing method for this study was found to be the standard normal variate transformation combined with the first derivative. For both full spectrum and VIP scores model, the prediction performance of the hybrid model was slightly worse than those of the specific models but was nevertheless satisfactory. Moreover, the VIP scores model obtained generally better performances than corresponding full spectrum model. Wavenumbers around 4500 cm-1, 4664 cm-1 and 4836 cm-1 were found to be the key wavenumbers in modeling protein content in these plant feed materials. The values for the root mean square error of prediction (RMSEP) and the relative prediction deviation (RPD) obtained with the VIP scores hybrid model were 1.05% and 2.53 for corn DDGS, 0.98% and 4.17 for corn germ meal, 0.75% and 6.99 for corn gluten meal, 1.54% and 4.59 for DDG, and 0.90% and 3.33 for rapeseed meal, respectively. The results of this study demonstrate that the protein content in several types of plant feed materials can be determined using a hybrid near-infrared spectroscopy model. And VIP scores method can be used to improve the general predictability of hybrid model.
A reduced-size silicon micromachined high-Q resonator at 5.7 GHz (2002)

This paper depicts the progress toward a novel high-quality-factor miniaturized resonator operating in the 5.6-5.8-GHz range. The design of the resonator is based on a micromachined cavity loaded with a high dielectric-constant material. Energy is coupled into the cavity from input and output microstrip lines via slots. Quality factors up to 640 are demonstrated on silicon planar structures with a volume of 177 mm/sup 3/. Further size reduction yields a volume of 24.5 mm/sup 3/ and quality factors ranging from 152 to 197, while keeping the resonator integration ability. Bonding techniques and the dielectric loss of the loading material are proven to be the limiting factors in achieving higher quality factors.
Autoantibodies in Type 2 Diabetes Induce Stress Fiber Formation and Apoptosis in Endothelial Cells (2009)

Abstract Context: Macular edema contributes to visual impairment, and albuminuria is associated with increased cardiovascular mortality in adults with type 2 diabetes mellitus. These microvascular complications result from increased capillary leakage of plasma proteins whose causation is not completely understood. Objective: The objective of the present study was to test whether plasma from type 2 diabetes with maculopathy/albuminuria or control subjects contains autoantibodies that can induce apoptosis or activate Rho kinase (ROCK) in endothelial cells. Design: A cohort of Veterans Affairs Diabetes Trial adults (&gt;40 yr of age) was randomized to standard vs. intensive glycemic treatment lasting 5–7.5 yr. Setting: The study was conducted in outpatient clinics. Patients: Case and age-matched control subjects who differed for the baseline presence of significant diabetic maculopathy and/or progression to macro-albuminuria were included in the study. Intervention: Pharmacological and lifestyle interventions in the Veterans Affairs Diabetes Trial generally resulted in substantially improved glycemic, blood pressure, and lipid levels. Results: Autoantibodies from patients with macular edema or progression to albuminuria potently induced caspase-dependent apoptosis in endothelial cells (up to 60%), whereas IgG from age-matched normal plasma caused much less apoptosis (&lt;10%; P &lt; 0.0001). The active inhibitory autoantibodies triggered stress fiber formation in endothelial cells likely through the activation of Rho guanosine 5′-triphosphatase, which could be nearly completed inhibited by 10 μm Y27632, a specific ROCK inhibitor. Conclusions: These results suggest that autoantibodies from a subset of advanced type 2 diabetes may contribute to diabetic vascular complications by activating ROCK, inducing stress fiber formation and apoptosis in endothelial cells.
Perioperative use of botulinum toxin for movement disorder–induced cervical spine disease (1996)

Patients with cervical dystonia or tics of the nuchal muscles can develop serious cervical spine disease. We report a series of four patients who received botulinum toxin injections to control their movement disorders prior to their required surgery. One patient with cervical tic-induced radiculomyelopathy required botulinum toxin injection postoperatively to facilitate stabilization of the cervical fusion. Two patients with torticollis-induced cervical radiculomyelopathy, and one patient with dystonia-induced C5 fracture, had botulinum toxin injected preoperatively to facilitate postoperative recovery. Botulinum toxin appears to be a useful adjunct in the treatment of cervical movement disorders prior to or following surgery for associated cervical spine disease.
Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4 (2016)

Toll-like receptors (TLRs) are the most upstream pattern recognition receptors in the cell, which detect pathogen associated molecular patterns and initiate signal transduction, culminating in the transcription of pro-inflammatory cytokines and antiviral interferon. Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key mediator in TLR (except for TLR3) and interleukin-1 receptor signaling pathways. The loss of kinase function of IRAK4 is associated with increased susceptibility to various pathogens, while its over-activation causes autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and cancer. The therapeutic importance of this master kinase has been advocated by a number of recent preclinical studies, where potent inhibitors have been administered to improve various TLR-mediated pathologies. Increasing studies of X-ray crystallographic structures with bound inhibitors have improved our knowledge on the molecular recognition of ligands by IRAK4, which will be crucial for the development of new inhibitors with improved potencies. In this review, we briefly discuss the structural aspect of ligand recognition by IRAK4 and highlight its therapeutic importance in the context of TLR-associated unmet medical needs.
Recording and Control System for Infra-Red Spectrophotometer (1947)

The recording system employs a contact-modulated amplifier and self-balancing potentiometer in an electrical null circuit including variable response speed and gain. The control system automatically adjusts the slits and zero at preselected prism positions. Familiar spectra illustrate the effects of variables such as slit width, recording speed, and response speed.
Antioxidant Drug Approved for ALS (2017)

A drug that was approved 2 years ago in Japan and South Korea for patients with amyotrophic lateral sclerosis (ALS) now is FDA approved for the same indication. Edaravone is the first ALS drug to gain approval since the agency sanctioned riluzole in 1995.
Angiotensin II-induced hypertension in the rat. Effects on the plasma concentration, renal excretion, and tissue release of prostaglandins. (1983)

We examined in rats the effects of intraperitoneal angiotensin II (AII) infusion for 12 d on urinary excretion, plasma concentration, and in vitro release of prostaglandin (PG) E2 and 6-keto-PGF1 alpha, a PGI2 metabolite. AII at 200 ng/min increased systolic blood pressure (SBP) progressively from 125 +/- 3 to 170 +/- 9 mmHg (P less than 0.01) and elevated fluid intake and urine volume. Urinary 6-keto-PGF1 alpha excretion increased from 38 +/- 6 to 55 +/- 5 and 51 +/- 7 ng/d (P less than 0.05) on days 8 and 11, respectively, of AII infusion, but urinary PGE2 excretion did not change. Relative to a control value of 129 +/- 12 pg/ml in vehicle-infused (V) rats, arterial plasma 6-keto-PGF1 alpha concentration increased by 133% (P less than 0.01) with AII infusion. Aortic rings from AII-infused rats released more 6-keto-PGF1 alpha (68 +/- 7 ng/mg) during 15-min incubation in Krebs solution than did rings from V rats (40 +/- 3 ng/mg); release of PGE2, which was less than 1% of that of 6-keto-PGF1 alpha, was also increased. Slices of inner renal medulla from AII-infused rats released more 6-keto-PGF1 alpha (14 +/- 1 ng/mg) during incubation than did slices from V rats (8 +/- 1 ng/mg, P less than 0.05), but PGE2 release was not altered. In contrast, AII infusion did not alter release of 6-keto-PGF1 alpha or PGE2 from inferior vena cava segments or from renal cortex slices. Infusion of AII at 125 ng/min also increased SBP, plasma 6-keto-PGF1 alpha concentration, and in vitro release of 6-keto-PGF1 alpha from rings of aorta and renal inner medulla slices; at 75 ng/min AII had no effect. SBP on AII infusion day 11 correlated positively with both 6-keto-PGF1 alpha plasma concentration (r = 0.54) and net aortic ring release (r = 0.70) when data from all rats were combined. We conclude that augmentation of PGI2 production is a feature of AII-induced hypertension. The enhancement of PGI2 production may be an expression of nonspecific alteration in vascular structure and metabolic functions during AII-induced hypertension, as well as the result of a specific effect of the peptide on the arachidonate-prostaglandin system.
Identification of a new P1 residue mutation (444Arg→Ser) in a dysfunctional C1 inhibitor protein contained in a type II hereditary angioedema plasma (1990)

A new reactive-centre P1 residue mutation (444Arg----Ser), has been identified in a dysfunctional C1 inhibitor protein, C1 inhibitor(Ba), contained in a type II hereditary angioedema plasma. This substitution is compatible with a point mutation of the 444Arg codon (CGC----AGC), and represents the first non-histidine, non-cysteine P1 residue mutant described for C1 inhibitor.
Layer-by-Layer Construction of SiOx Film on Oxide Semiconductors (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLayer-by-Layer Construction of SiOx Film on Oxide SemiconductorsHiroaki TadaCite this: Langmuir 1995, 11, 9, 3281–3284Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/la00009a001https://doi.org/10.1021/la00009a001research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies (2016)

The need for alternatives to animal experimentation and traditional testing methods has been widely discussed in recent years. This has led scientists and regulatory authorities to investigate alternative methods for toxicity testing. High-content screening (HCS) has emerged as a powerful tool in predictive toxicology since it permits molecular, cellular and tissue-based toxicity assessments. HCS allows automated image acquisition and analysis, and provides information on multiple properties of individual cells loaded simultaneously with fluorescent dyes, which is used for drug safety evaluations. Areas covered: Herein, the authors review the principles of HCS technology and some of the most widely used HCS assays for studying drug-induced hepatotoxicity in preclinical studies in general and in the pharmaceutical industry in particular. Expert opinion: The widespread acceptation of HCS by pharmaceutical companies and academic researchers highlights the potential usefulness of this technology as a prioritization tool in drug development. The improvement of different key points such as fluorescent probes or bioinformatics tools will consolidate HCS in drug discovery.
Missense mutations in β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause Walker–Warburg syndrome (2013)

Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (αDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2. Mutations in these glycosyltransferase genes result in defective αDG glycosylation and reduced ligand binding by αDG causing a clinically heterogeneous group of congenital muscular dystrophies, commonly referred to as dystroglycanopathies. The most severe clinical form, Walker-Warburg syndrome (WWS), is characterized by congenital muscular dystrophy and severe neurological and ophthalmological defects. Here, we report two homozygous missense mutations in the β-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) gene in a family affected with WWS. Functional studies confirmed the pathogenicity of the mutations. First, expression of wild-type but not mutant B3GNT1 in human prostate cancer (PC3) cells led to increased levels of αDG glycosylation. Second, morpholino knockdown of the zebrafish b3gnt1 orthologue caused characteristic muscular defects and reduced αDG glycosylation. These functional studies identify an important role of B3GNT1 in the synthesis of the uncharacterized laminin-binding glycan of αDG and implicate B3GNT1 as a novel causative gene for WWS.
An electro-optic-based RMS voltage measurement techniquea) (1995)

A new electro-optic-based technique for measuring the rms value of an applied voltage is presented. The technique incorporates a ratiometric method whereby the requirement for absolute laser power information is unnecessary. Description, analysis, and experimental results of the prototype measurement system are presented.
Cold-cathode gas-discharge ion source (1986)

Pt coated Au NP offer promising opportunity in cancer therapeutic and warrants advanced study in vivo models of cancer.
Advances in Temporary Bonding and Debonding Technologies for use with Wafer-Level System-in-Package (WLSiP) and Fan-Out Wafer-Level Packaging (FOWLP) Processes (2018)

Abstract Today's complex fan-out wafer-level packaging (FOWLP) processes include the use of redistribution layers (RDL) and reconstituted wafers with epoxy mold compound (EMC) for use in heterogeneous integration [1]. Wafer-level system-in-package (WLSiP) uses fan-out wafer-level packaging (FOWLP) to build the system-in-package (SiP) by attaching know-good die (KGD) in a chip-first process to a tape laminated temporary carrier. If the dies are attached in a die-up configuration (active area facing up) and then over-molded with EMC, contact pads on the embedded die are exposed during the backside grind process. During the RDL build, the temporary carrier supplies mechanical support for the thinned substrate. In a die-down configuration with the active area facing down (eWLB), the temporary carrier is removed after the molding process thus exposing the contact pads for RDL build and solder ball mount. The ideal chip attachment scheme should minimize lateral movement of the die during over-mold (die shift) and also minimize vertical deformation of the bonding material. Thermal release tape provides a convenient way to attach die to a carrier prior to over-molding with EMC. However, not all bonding materials are suitable for presentation in tape form, so the material used in the tape may not be the optimal choice. An alternative method is to directly apply temporary bonding material to the carrier substrate. This enables the use of bonding materials with higher melt viscosity and improved thermal stability, resulting in less vertical deformation during die placement, and reduced die shift during over-molding. The bonding material will ideally have high adhesion to the EMC wafer to prevent delamination in the bond line during downstream processing. Stack stress and warpage is a major concern which causes handling and alignment problems during processing. The bonding material and carrier will need to be specifically suited to minimize the effects of stress in the compound wafer. Such material must balance rigidity with warp to prevent lateral die shift and deformation induced by coefficient of thermal expansion (CTE) mismatch between the carrier and EMC material [2]. Bonding materials must also have enough adhesion to the EMC material to overcome such stress without bond failure for an associated debond path (such as laser or mechanical release). In this experiment, we will examine a thermoplastic bonding material in combination with different release materials, addressing die shift, and deformation after EMC processing. Successful pairs will then undergo carrier release using either mechanical release or laser ablation release technology.
One‐Year Experience in the Treatment of Benign Prostatic Hyperplasia with Finasteride (1991)

Abstract Finasteride (MK‐906) is a 5α‐reductase inhibitor that reduces circulating dihydrotestosterone (DHT) levels without lowering testosterone levels. The goal of this study was to evaluate the effects of long‐term (12 months) treatment with finasteride in 67 men with benign prostatic hyperplasia to determine if previously reported short‐term efficacy was maintained with chronic therapy. Treatment with 10 mg of finasteride resulted in a 78% to 80% reduction in DHT levels (P < 0.001) levels, and a small but significant increase in testosterone levels (P < 0.05) that were maintained over the 12‐month period. Significant reduction in prostate volume was observed after 6 months of treatment and maintained at month 12 (P < 0.05). In patients with baseline maximum flow rates ≤15 ml/second, maximum urinary flow significantly increased by a mean of 4 ml/second (P < 0.01), with at least a 3 ml/second improvement observed in up to 70% of the patients at month 12. These results indicate that finasteride can reduce prostate size and improve maximum urinary flow with no loss of efficacy after 1 year of treatment. It is concluded that finasteride has the potential to be an effective chronic therapy for benign prostatic hyperplasia.
Information limits on neural identification of colored surfaces in natural scenes (2004)

If surfaces in a scene are to be distinguished by their color, their neural representation at some level should ideally vary little with the color of the illumination. Four possible neural codes were considered: von-Kries-scaled cone responses from single points in a scene, spatial ratios of cone responses produced by light reflected from pairs of points, and these quantities obtained with sharpened (opponent-cone) responses. The effectiveness of these codes in identifying surfaces was quantified by information-theoretic measures. Data were drawn from a sample of 25 rural and urban scenes imaged with a hyperspectral camera, which provided estimates of surface reflectance at 10-nm intervals at each of 1344 x 1024 pixels for each scene. In computer simulations, scenes were illuminated separately by daylights of correlated color temperatures 4000 K, 6500 K, and 25,000 K. Points were sampled randomly in each scene and identified according to each of the codes. It was found that the maximum information preserved under illuminant changes varied with the code, but for a particular code it was remarkably stable across the different scenes. The standard deviation over the 25 scenes was, on average, approximately 1 bit, suggesting that the neural coding of surface color can be optimized independent of location for any particular range of illuminants.
<tt>i- flow</tt>: High-dimensional integration and sampling with normalizing flows (2020)

In many fields of science, high-dimensional integration is required. Numerical methods have been developed to evaluate these complex integrals. We introduce the code i-flow, a python package that performs high-dimensional numerical integration utilizing normalizing flows. Normalizing flows are machine-learned, bijective mappings between two distributions. i-flow can also be used to sample random points according to complicated distributions in high dimensions. We compare i-flow to other algorithms for high-dimensional numerical integration and show that i-flow outperforms them for high dimensional correlated integrals. The i-flow code is publicly available on gitlab at https://gitlab.com/i-flow/i-flow.
Documentation of corneal epithelial defects with fluorescein‐enhanced digital fundus camera photography (2008)

The advent of digital photography in the ophthalmic setting has provided not only a means of documenting pathology, but with instantaneous results, it is possible to aid clinical diagnosis and management. This study was designed to demonstrate the ability to image corneal epithelial lesions stained with fluorescein, with a digital fundus camera set on fluorescein angiography settings. The contrast of this technique demonstrated both gross and subtle corneal epithelial lesions better than traditional methods. The results obtained demonstrated the high sensitivity and high contrast images this technique can facilitate in every ophthalmic practice equipped with a fundus camera with digital fluorescein angiography capability.
Spectrophotometric Determination of Technetium with Toluene-3,4-dithiol (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrophotometric Determination of Technetium with Toluene-3,4-dithiolF. J. Miller and P. F. ThomasonCite this: Anal. Chem. 1961, 33, 3, 404–406Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/ac60171a029https://doi.org/10.1021/ac60171a029research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts