gebhart/patrepeval huggingface dataset:
Review of: <i>Effective Interviewing and Interrogation Techniques</i> (2004)

Abstract This text is one of a limited number of books which address the subject of the use of interviewing and interrogation techniques by professional investigators. The authors of Effective Interviewing and Interrogation Techniques are polygraph examiners who also conduct training for polygraph examiners and for interviewers. The authors tip their hats to a series of past and current polygraph examiners who have written and lectured on the subject since the 1930s.
Formulation of Ranitidine Pellets by Extrusion-Spheronization with Little or No Microcrystalline Cellulose (1999)

The present study was concerned with the feasibility of formulating ranitidine into pellets with a range of alternative excipients in place of microcrystalline cellulose (MCC). Eight ranitidine formulations employing two or more of the excipients lactose, barium sulfate, glyceryl monostearate, and MCC were processed by extrusion-spheronization, and characterized according to a series of physico-mechanical and dissolution criteria. Formulations containing lactose produced unsatisfactory pellets of wide size distribution and irregular shape, whereas formulations incorporating barium sulfate and glyceryl monostearate with or without MCC resulted in relatively spherical pellets of narrow size distribution and good mechanical properties. Ranitidine release was found to be rapid and virtually complete within 15 min, regardless of the pellet formulation. A direct relationship was observed between the concentration of MCC in the formulation and the properties of the pellets. In general, the higher the concentration of MCC, the rounder, stronger, and less friable the pellets. However, even pellets without MCC were also successfully prepared with a superior size distribution and shape over those with MCC. Overall, these results confirm that ranitidine can be formulated into pellet dosage forms with little or no MCC by the extrusion-spheronization process.
Complications in endoscopic intranasal ethmoidectomy: An update (1989)

A previous publication by this author discussing complications of endoscopic intranasal ethmoidectomy indicated an overall complication rate of 29% in 90 patients (17% in 150 ethmoidectomies). Compared to published complications rates for traditional intranasal ethmoidectomy (2.7% to 3.7%), 17% is alarming and of concern. The complication results in 300 ethmoidectomies performed on 180 patients are presented. The overall complication rate was 9.3%. Only two further complications have occurred since the first reported series: a cerebrospinal fluid leak and one case of subcutaneous emphysema. Methods and techniques that have led to the reduction of complications are briefly discussed. Endoscopic ethmoidectomy is a valid, safe procedure in experienced hands.
Comparing Immersion in Collaborative Ideation through Design Conversations, Workload and Experience (2011)

This paper presents a case study comparing the HIS (Hybrid Ideation Space), a system allowing designers to be physically immersed in their sketches and physical models, and VyewÂ, a whiteboard software, in local and remote design collaboration; aiming to see if immersion benefits collaborative ideation. Three methodological tools were used: Design Conversations (Collaborative Ideation Loop ÂCI-LoopÂ, Collaborative Conversations ÂCCÂ and Collaborative Moving ÂCMÂ), Workload using NASA TLX and Design Flow for the designersÂ experience. Local collaboration results appear to have benefited from immersion while remote results were mitigated by participant issues. However, looking deeper into usersÂ experience explains the impact of immersion.
Manoeuvre detection and track correction by input estimation (1993)

The paper gives a simplified solution to the input estimation method of tracking a manoeuvring target. Manoeuvre detection is decoupled from input estimation and does not require estimates of the manoeuvre inputs. Instead, the detection variable is a normalised sum of the differences between the measurements and the Kalman filter projections of positions. For the same probability of false alarm, the resultant detector has a higher probability of detecting than the innovations-based detector. The input estimator uses the same position differences to give a generalised least squares estimation of the manoeuvre inputs. No matrix inversion is needed and many calculations can be done offline. Thus, this input estimation detection scheme is applicable to cases where several trackers are run simultaneously and where real-time constraint is a problem. The theoretical development is verified by simulation results, which also contain some tracking examples of typical target manoeuvres.
Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. (1997)

Calmodulin-dependent protein kinases phosphorylate certain substrates that have been implicated in regulating cellular proliferation. For example, upon mitogenic stimulation, there is a rapid activation of calmodulin-dependent protein kinase III (CaM kinase III), which leads to the phosphorylation of elongation factor 2. Recently, our laboratory demonstrated that the activity of CaM kinase III is increased in glioma cells following exposure to mitogens and is diminished or absent in nonproliferating glial tissue. Rottlerin, a 5,7-dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-methyl-5-acetylbenzy l)-8-cinnamoyl-1,2-chromene isolated from the pericarps of Mallotus phillippinensis, has been shown to be an effective CaM kinase III inhibitor. Therefore, we evaluated the effects of rottlerin on the growth and viability of glioblastoma cell lines. Rottlerin decreased growth and induced cytotoxicity in rat (C6) and two human gliomas (T98G and U138MG) at concentrations that inhibited the activity of CaM kinase III in vitro and in vivo. Far less demonstrable effects were observed on other Ca2++/CaM-sensitive kinases. Incubation of glial cells with rottlerin produced a block at the G1-S interface and the appearance of a population of cells with a <2N complement of DNA. In addition, rottlerin induced changes in cellular morphology such as cell shrinkage, accumulation of cytoplasmic vacuoles, and packaging of cellular components within membranes. These data suggest that CaM kinase III may be an important link between the activation of CaM-dependent signaling, proliferation, and viability in malignant cells, and that inhibition of CaM kinase III may represent an interesting pharmacological target in malignant gliomas.
A new design criteria for hash-functions (2005)

Abstract. The most common way of constructing a hash function (e.g., SHA-1) is to iterate a compression function on the input message. The compression function is usually designed from scratch or made out of a block-cipher. In this paper, we introduce a new security notion for hash-functions, stronger than collision-resistance. Under this notion, the arbitrary length hash function H must behave as a random oracle when the fixed-length building block is viewed as an ideal primitive. This enables to eliminate all possible generic attacks against iterative hash-functions. In this paper, we show that the current design principle behind hash functions such as SHA-1 and MD5 — the (strengthened) Merkle-Damg˚ard transformation — does not satisfy this security notion. We provide several constructions that provably satisfy this notion; those new constructions introduce minimal changes to the plain Merkle-Damg˚ard construction and are easily implementable in practice. This paper is a modified version of a paper to appear at Crypto 2005. 1
ChemInform Abstract: A Convenient Method of meta‐Directing Nitration of 3‐Substituted Phenols by Lanthanoid(III) Nitrates. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence (2017)

Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms. Plant-based "phytomedicines" may provide novel treatment options, to act as an adjunctive or alternative to existing anxiolytic medications. As such, we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and/or phytoconstituents. An open-ended search to 5 July 2017 was conducted using MEDLINE (PubMed), Scopus, and Cochrane library online databases and performed in a stepped format from preclinical to clinical investigations. Eligible studies must have had (a) in vitro evidence of GABA-modulating activity, (b) animal studies using anxiety models to test an anxiolytic effect, and (c) human clinical trials. Ten phytomedicines were identified as having preclinical investigations showing interaction with the GABA system, in addition to human clinical trials: kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm. Collectively, the literature reveals preclinical and clinical evidence for various phytomedicines modulating GABA-pathways, with comparative anxiolytic effect to the current array of pharmaceuticals, along with good safety and tolerability profiles.
T2* relaxometry of fetal brain at 1.5 Tesla using a motion tolerant method (2014)

Fetal T2* values are higher than those previously reported for preterm neonates and decline with a consistent trend across gestational age. The data suggest that longer than usual echo times or direct T2* measurement should be considered when performing fetal fMRI to reach optimal BOLD sensitivity.
Heterozygous<i>HTRA1</i>mutations are associated with autosomal dominant cerebral small vessel disease (2015)

Cerebral small vessel disease represents a heterogeneous group of disorders leading to stroke and cognitive impairment. While most small vessel diseases appear sporadic and related to age and hypertension, several early-onset monogenic forms have also been reported. However, only a minority of patients with familial small vessel disease carry mutations in one of known small vessel disease genes. We used whole exome sequencing to identify candidate genes in an autosomal dominant small vessel disease family in which known small vessel disease genes had been excluded, and subsequently screened all candidate genes in 201 unrelated probands with a familial small vessel disease of unknown aetiology, using high throughput multiplex polymerase chain reaction and next generation sequencing. A heterozygous HTRA1 variant (R166L), absent from 1000 Genomes and Exome Variant Server databases and predicted to be deleterious by in silico tools, was identified in all affected members of the index family. Ten probands of 201 additional unrelated and affected probands (4.97%) harboured a heterozygous HTRA1 mutation predicted to be damaging. There was a highly significant difference in the number of likely deleterious variants in cases compared to controls (P = 4.2 × 10(-6); odds ratio = 15.4; 95% confidence interval = 4.9-45.5), strongly suggesting causality. Seven of these variants were located within or close to the HTRA1 protease domain, three were in the N-terminal domain of unknown function and one in the C-terminal PDZ domain. In vitro activity analysis of HTRA1 mutants demonstrated a loss of function effect. Clinical features of this autosomal dominant small vessel disease differ from those of CARASIL and CADASIL by a later age of onset and the absence of the typical extraneurological features of CARASIL. They are similar to those of sporadic small vessel disease, except for their familial nature. Our data demonstrate that heterozygous HTRA1 mutations are an important cause of familial small vessel disease, and that screening of HTRA1 should be considered in all patients with a hereditary small vessel disease of unknown aetiology.
Recent applications of deep learning and machine intelligence on in silico drug discovery: methods, tools and databases (2018)

The identification of interactions between drugs/compounds and their targets is crucial for the development of new drugs. In vitro screening experiments (i.e. bioassays) are frequently used for this purpose; however, experimental approaches are insufficient to explore novel drug-target interactions, mainly because of feasibility problems, as they are labour intensive, costly and time consuming. A computational field known as 'virtual screening' (VS) has emerged in the past decades to aid experimental drug discovery studies by statistically estimating unknown bio-interactions between compounds and biological targets. These methods use the physico-chemical and structural properties of compounds and/or target proteins along with the experimentally verified bio-interaction information to generate predictive models. Lately, sophisticated machine learning techniques are applied in VS to elevate the predictive performance. The objective of this study is to examine and discuss the recent applications of machine learning techniques in VS, including deep learning, which became highly popular after giving rise to epochal developments in the fields of computer vision and natural language processing. The past 3 years have witnessed an unprecedented amount of research studies considering the application of deep learning in biomedicine, including computational drug discovery. In this review, we first describe the main instruments of VS methods, including compound and protein features (i.e. representations and descriptors), frequently used libraries and toolkits for VS, bioactivity databases and gold-standard data sets for system training and benchmarking. We subsequently review recent VS studies with a strong emphasis on deep learning applications. Finally, we discuss the present state of the field, including the current challenges and suggest future directions. We believe that this survey will provide insight to the researchers working in the field of computational drug discovery in terms of comprehending and developing novel bio-prediction methods.
Predicting angulational development and eruption of the lower third molar. (1978)

Abstract No Abstract Available. From the Departments of the Pedodontics, Orthodontics and Roentgenology, Institute of Dentistry, University of Helsinki.
A FLUID MIXING LASER (1966)

Helium-neon CW laser oscillations at 1.1523 μ have been observed in a high-velocity gas flow system utilizing the rapid mixing of metastable helium atoms with initially unexcited neon.
Plasma membrane caveolae mediate the efflux of cellular free cholesterol (1995)

Caveolae are clathrin-free cell-surface organelles implicated in transmembrane transport. A fibroblast caveolar membrane fraction was isolated by sucrose density gradient ultracentrifugation and its identity confirmed by protein markers (caveolin, annexin II). When 3H-labeled free cholesterol was selectively transferred to the cells from labeled low density lipoprotein to increase cell free cholesterol approximately 15%, there was a 6-fold increase in label in the caveolar fraction above baseline levels. Subsequent incubation of these cells with unlabeled native plasma or plasma high density lipoprotein selectively unloaded caveolar free cholesterol into the medium. Okadaic acid, which decreased caveolar activity as measured by cholera toxin binding and uptake, decreased cholesterol efflux in parallel. Cholesterol newly synthesized from [3H]mevalonate was also preferentially incorporated into the caveolar fraction and selectively released by plasma into the medium. Together these data indicate that caveolae represent a major site of efflux of both newly synthesized and low density lipoprotein-derived free cholesterol in these cells.
A graph-theoretic sufficient condition for FPGA/FPIC switch-module routability (2002)

Switch modules are the most important component of the routing resources in FPGAs/FPICs. We consider in this paper an FPGA/FPIC switch-module analyse's problem: The inputs consist of a switch-module description and the number of nets required to be routed through the switch module; the question is to determine if there exists a feasible routing for the routing requirements on the switch module. This problem is applicable to the routability evaluation of FPGA/FPIC switch modules, the switch-module design for FPGAs/FPICs, and FPGA/FPIC routing. We present a graph-theoretic sufficient condition for the analyse's problem. The implications of the condition are: (1) there exist several classes of efficient approximation algorithms for the analysis problem; (2) there exist several classes of switch-module architectures on which the analysis problem can be solved efficiently.
Compressive Structured Light for Recovering Inhomogeneous Participating Media (2012)

We propose a new method named compressive structured light for recovering inhomogeneous participating media. Whereas conventional structured light methods emit coded light patterns onto the surface of an opaque object to establish correspondence for triangulation, compressive structured light projects patterns into a volume of participating medium to produce images which are integral measurements of the volume density along the line of sight. For a typical participating medium encountered in the real world, the integral nature of the acquired images enables the use of compressive sensing techniques that can recover the entire volume density from only a few measurements. This makes the acquisition process more efficient and enables reconstruction of dynamic volumetric phenomena. Moreover, our method requires the projection of multiplexed coded illumination, which has the added advantage of increasing the signal-to-noise ratio of the acquisition. Finally, we propose an iterative algorithm to correct for the attenuation of the participating medium during the reconstruction process. We show the effectiveness of our method with simulations as well as experiments on the volumetric recovery of multiple translucent layers, 3D point clouds etched in glass, and the dynamic process of milk drops dissolving in water.
HDTV broadcast, from studio to home (1992)

The authors describe recent trends in HDTV facilities and equipment, and also the present state and the direction of HDTV home receivers in Japan. The HDTV broadcasting system in Japan is outlined. HDTV studio equipment is discussed. Technical and price trends for HDTV receivers are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermoplasticity and parallel-plate poling of electro-optic polyimide host thin films (1992)

We demonstrate the first polyimide guest/host system which exhibits stable electro-optic response after parallel-plate poling. Such systems are based on a class of polyimides which, once cured, possess a clear glass transition in their dielectric relaxation spectra, characteristic of thermoplasticity. After doping with compatible nonlinear optical molecules the polyimide host system can first be thermally imidized (cured) and then poled with an electric field. High glass transition temperatures are achieved leading to excellent thermal stability of the poled electro-optic response.
Reviews of Books (1955)

Journal Article Reviews of Books Get access Rome beyond the Imperial Frontiers. By MORTIMER WHEELER. (London: George Bell, 1954.) A. H. M. JONES A. H. M. JONES Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXX, Issue CCLXXVI, July 1955, Pages 435–438, https://doi.org/10.1093/ehr/LXX.CCLXXVI.435 Published: 01 July 1955
Chip to wafer direct bonding technologies for high density 3D integration (2012)

We demonstrate chip to wafer assembly based on aligned Cu-Cu direct bonding. A collective die surface preparation for direct bonding has implemented to develop dies direct bonding, defect free. An accurate pick and place equipment was adapted to ensure a particle free environment. After a damascene-like surface preparation, chips were bonded with less than 1μm misalignment. 400°C bonded daisy chains on die to wafer structure are perfectly ohmic. Concurrently, to overcome speed limitation of pick and place technique, a self-assembly technique chip is developed. This technique is based on capillary effect for self alignment and direct bonding for assembly. A less than 1 μm alignment accuracy and a 90 per cent self assembly process yield are obtained.
Inside Cover: Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities (ChemBioChem 12/2009) (2009)

The inside cover picture shows the culmination of a rational drug discovery program of Stat3 inhibitors. Computational modeling of the most potent salicylic acid-based therapeutic shows excellent occupation of the Stat3-SH2 domain, thereby inhibiting its homodimerization. For details, see the communication by P. T. Gunning et al. on p. 1959 ff.
Cloning and assessment of mycobacterial promoters by using a plasmid shuttle vector (1993)

We have constructed a promoter selection vector for mycobacteria to analyze the sequences involved in mycobacterial transcriptional regulation. The vector pSD7 contains extrachromosomal origins of replication from Escherichia coli as well as from Mycobacterium fortuitum and a kanamycin resistance gene for positive selection in mycobacteria. The promoterless chloramphenicol acetyltransferase (CAT) reporter gene has been used to detect mycobacterial promoter elements in a homologous environment and to quantify their relative strengths. Using pSD7, we have isolated 125 promoter clones from the slowly growing pathogen Mycobacterium tuberculosis H37Rv and 350 clones from the fast-growing saprophyte Mycobacterium smegmatis. The promoters exhibited a wide range of strengths, as indicated by their corresponding CAT reporter activities (5 to 2,500 nmol/min/mg of protein). However, while most of the M. smegmatis promoters supported relatively higher CAT activities ranging from 100 to 2,500 nmol/min/mg of protein, a majority of those from M. tuberculosis supported CAT activities ranging from 5 to only about 100 nmol/min/mg of protein. Our results indicate that stronger promoters occur less frequently in the case of M. tuberculosis compared with M. smegmatis. To assess the extent of divergence of mycobacterial promoters vis-à-vis those of E. coli, the CAT activities supported by the promoters in E. coli were measured and compared with their corresponding activities in mycobacteria. Most of the mycobacterial promoter elements functioned poorly in E. coli. The homologous selection system that we have developed has thus enabled the identification of mycobacterial promoters that apparently function optimally only in a native environment.