gebhart/patrepeval huggingface dataset:
STUDIES IN PIPERIDONE CHEMISTRY. I. A SYNTHESIS OF 5-HOMOPIPERAZINONES (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSTUDIES IN PIPERIDONE CHEMISTRY. I. A SYNTHESIS OF 5-HOMOPIPERAZINONESS. C. DICKERMAN and H. G. LINDWALLCite this: J. Org. Chem. 1949, 14, 4, 530–536Publication Date (Print):July 1, 1949Publication History Published online1 May 2002Published inissue 1 July 1949https://doi.org/10.1021/jo01156a005RIGHTS & PERMISSIONSArticle Views558Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (492 KB) Get e-Alerts Get e-Alerts
Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes. (1994)

While the mitogen-activated protein kinase (MAPK) pathway coupled to receptor tyrosine kinases has been largely clarified, little is known about MAPK activation mediated by heterotrimeric G protein-coupled receptors. In a previous study, it has been shown that endothelin-1 (ET-1) signaling through heterotrimeric G protein-coupled receptors stimulates MAPK activity in primary cultures of astrocytes (Cazaubon, S., Parker, P. J., Strosberg, A.D., and Couraud, P.O. (1993) Biochem. J. 293, 381-386). To clarify the molecular mechanism responsible for this response, involvement of the adapter proteins, Shc and Grb2, has now been investigated. It is shown here that in these cells, ET-1 stimulates tyrosine phosphorylation of Shc, resulting in its stable association with Grb2 but not with Grb3-3, a Grb2 isoform with partially deleted SH2 domain. These results demonstrate that tyrosine-phosphorylated Shc specifically interacts with the SH2 domain of Grb2. This response was rapid and transient, showing a maximum at 10 min and declining at 60 min. Interestingly, direct activation of G proteins by fluoroaluminate mimics the ET-1 effect. In addition, a shift to a higher apparent molecular mass of Raf-1 kinase, likely reflecting its hyperphosphorylation, was also detected in ET-1-treated cells. These data strongly suggest that ET-1-induced MAPK activation is a G protein-coupled pathway that involves Shc, Grb2, and probably Raf-1. In conclusion, the Shc-Grb2 complex may be involved in the activation of the MAPK pathway, not only by several receptor tyrosine kinases but also by heterotrimeric G protein-coupled receptors, such as ET-1 receptors.
Reactive Facet Sputtering of SiO2 (1994)

Reactive facet sputtering of using in Ar was conducted in a magnetically enhanced, single‐wafer, parallel plate plasma system. Scanning electron microscope (SEM) evaluation of profiles generated after sputtering showed that the faceting effect was lost at concentrations higher than 4% in Ar. Addition of increased the etch rate as well as improved the etch uniformity. Fourier transform infrared (FTIR) evaluation of the sputtered film showed no adverse effects due to the presence of in the reaction medium.
Heritability and Genetic Linkage of Plasma Natriuretic Peptide Levels (2003)

In this community-based sample, a substantial proportion of the unexplained variation in plasma natriuretic peptide levels was attributable to additive genetic effects. Additional studies using candidate gene approaches may provide insight into the genetic loci that regulate plasma natriuretic peptide levels in humans.
Laser-assisted deposition of nanometer structures using a scanning tunneling microscope (1990)

Nanometer-scale deposits as small as 1 nm have been made on graphite surfaces using laser-induced multiphoton fragmentation and ionization of trimethylaluminum (TMA) molecules in the tunneling junction of a scanning tunneling microscope. Laser radiation generates ions, which are guided to the surface by the electric field between the tip and the surface. The resolution of this technique is limited by the extent of the field in the tunneling junction.
Food waste conversion to microbial polyhydroxyalkanoates (2017)

Polyhydroxyalkanoates (PHAs) are biopolymers with desirable material properties similar to petrochemically derived plastics. PHAs are naturally produced by a wide range of microorganisms as a carbon storage mechanism and can accumulate to significantly high levels. PHAs are an environmentally friendly alternative to their petroleum counterparts because they can be easily degraded, potentially reducing the burden on municipal waste systems. Nevertheless, widespread use of PHAs is not currently realistic due to a variety of factors. One of the major constraints of large-scale PHA production is the cost of carbon substrate for PHA-producing microbes. The cost of production could potentially be reduced with the use of waste carbon from food-related processes. Food wastage is a global issue and therefore harbours immense potential to create valuable bioproducts. This article's main focus is to examine the state of the art of converting food-derived waste into carbon substrates for microbial metabolism and subsequent conversion into PHAs.
Mechanism of aminoglycoside enhancement of <i>Staphylococcus aureus</i> adherence to HeLa cells (1991)

There is enhanced adherence of Staphylococcus aureus to HeLa cells if the organism is grown in the presence of sub-lethal concentration of aminoglycosides. In this study, we investigated the mechanism of this enhancement. Cell surface components obtained by lysosaphin digestion under hypertonic conditions were examined for binding to HeLa cells. The components considered responsible for the adherence were recovered more from aminoglycoside treated cells than from control, benzylpenicillin or chloramphenicol treated cells. Using a contact angle measurement, the bacterial cell surface was found to be more hydrophobic after growing in the presence of some aminoglycosides, and hydrophilic which decreased adherence, after growing in the presence of benzylpenicillin and ofloxacin. Spectinomycin and kasugamycin, which are both aminoglycosides which do not cause misreading, failed to enhance adherence suggesting that misreading caused by aminoglycosides plays an important role in the enhancement of adherence.
Fast Rate Electrodeposition (1975)

SummaryAgitation and other means of rapid ion transport and diffusion for achieving fast rate electro-deposition are quantitatively related to other factors influencing the properties and characteristics of the deposits. A practical means for depositing dense, fine grained metals and alloys utilises turbulent solution flow in a narrow channel between conforming cathode surfaces and soluble or insoluble anodes. Solutions and conditions for deposition at rates from 20 to 100 μm/min are correlated with property data for several metals and alloys.
SVM-Fold: a tool for discriminative multi-class protein fold and superfamily recognition (2007)

By combining state-of-the-art SVM kernel methods with a novel multi-class algorithm, the SVM-Fold system delivers efficient and accurate protein fold and superfamily recognition.
A New Method for Cytodestruction of Bladder Epithelium Using Protamine Sulfate and Urea (1994)

Bladder epithelium relies primarily on the presence of a surface glycosaminoglycan (GAG) layer and the structural integrity of cell-cell contact to maintain impermeability to toxic urinary wastes. Previous clinical studies evaluating bladder permeability characteristics in interstitial cystitis patients had indicated that epithelial desquamation occurs after treatment with protamine sulfate (PS) followed by hypertonic urea. The following study was performed using rabbits to further investigate this finding. The urinary bladder was evaluated for optimal treatment conditions for epithelial removal. Protamine sulfate (1 to 10 mg./ml.) and urea (100 to 200 gm./ml.) were instilled into the bladder at volumes ranging from 5 to 60 ml. to that required for near maximum distention. After incubation at room temperature for 15 minutes, the bladders were fixed and evaluated histologically for epithelial removal. The maximum epithelial removal occurred when the bladders were distended, and when PS concentration was 5 to 10 mg./ml. and urea at 200 gm./l. There was greater epithelium removal after repeated treatments. Epithelial cells that were removed were not viable based on Trypan blue staining. There was no significant increase of C14 labeled urea in the plasma after 15 minutes. Rabbits that were followed for 6 weeks after treatment did not show any histological evidence of increased collagen deposition and/or fibrosis. This procedure may have important clinical value since it may remove sufficient bladder epithelium in patients with transitional cell carcinoma to have therapeutic benefit. This offers a realistic option for selective, nontoxic destruction of bladder epithelium.
Nutritional Requirements of Schistosoma japonicum Eggs (1983)

Newly laid eggs of Schistosoma japonicum were cultured in a serum-free, chemically defined medium, RPMI 1640, which contained 20 amino acids, glutathione, 11 vitamins, and glucose in a balanced salt solution. The requirements for these components in the nutrition of the eggs was investigated by the deletion of single component from the medium. The following 14 amino acids were shown to be essential for the full development of the egg in the medium: L-arginine, L-cystine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-tyrosine, and L-valine. Choline chloride was the essential vitamin. The omission of nicotinamide from the medium affected maturation adversely. Glucose was also required by the eggs. Minimal concentration of glucose for maturation of the eggs was 0.02 mM, but concentrations ranging from 0.16 to 20.00 mM gave better results while the concentration of the other elements of the medium were kept constant.
UHF RF Identification of People in Indoor and Open Areas (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The performance of an ultra-high-frequency RF identification (ID) system operating at 869 MHz, intended for the ID of persons in both indoor and open areas, has been validated using the propagation models, as well as the series of practical measurements. A two-ray propagation model and the 3-D ray-tracing model were used for calculations of all important system parameters in open and indoor areas, respectively. For the application mentioned above, a novel (electrically small and, at the same time, low-profile) wearable TAG antenna was designed. It was used in order to carry out the necessary tests as well. The antenna in question is based on an artificial-like surface. The latter provides an important screening effect and avoids detuning. Another virtue of the surface used is represented by the fact that it ensures the minimum loss of the antenna efficiency (resulting from the presence of a nearby human body). The simulations and measurements show that the optimized system can guarantee a reliable ID at distances up to 9 m in open areas and up to 16 m in corridors. </para>
Nuclear Import of the Retinoid X Receptor, the Vitamin D Receptor, and Their Mutual Heterodimer (2005)

The nuclear receptor retinoid X receptor (RXR) can regulate transcription through homotetramers, homodimers, and heterodimers with other nuclear receptors such as the vitamin D receptor (VDR). The mechanisms that underlie the nuclear import of RXR, VDR, and RXR-VDR heterodimers were investigated. We show that RXR and VDR translocate into the nucleus by distinct pathways. RXR strongly bound to importinbeta and was predominantly nuclear in the absence of ligand. Importin binding and nuclear localization of RXR were modestly enhanced by its ligand, 9-cis-retinoic acid. On the other hand, VDR selectively associated with importinalpha. Importin association and correspondingly nuclear import of VDR were markedly augmented by 1,25(OH)2D3. RXR-VDR dimerization inhibited the ability of RXR to bind importinbeta and to mobilize into the nucleus using its own nuclear localization signal. In contrast, VDR recruited RXR-VDR heterodimers to importinalpha and mediated nuclear import of the heterodimers in response to 1,25(OH)2D3. Hence nuclear import of RXR-VDR heterodimers is mediated preferentially by VDR and is controlled by the VDR ligand. The observations reveal a novel mechanism by which an RXR heterodimerization partner dominates the activity of the heterodimers.
School Resources and Student Outcomes: An Overview of the Literature and New Evidence from North and South Carolina (1996)

This paper reviews and interprets the literature on the effects of school resources on students’ eventual earnings and educational attainment. In addition, new evidence is presented on the impact of the great disparity in school resources between black and white students in North and South Carolina that existed in the first half of the twentieth century, and the subsequent narrowing of these resource disparities. Following birth cohorts over time, gaps in earnings and educational attainment for blacks and whites in the Carolinas tend to mirror the gaps in school resources.
HIV-1 Nef protein exhibits structural and functional similarity to scorpion peptides interacting with K+ channels (1991)

The persistent infection of human glial cells with HIV-1 is characterized by prominent expression of the Nef protein. In order to evaluate the possible role of Nef in the development of HIV-1-associated neurological disorders, we compared Nef with known neuroactive proteins. We found that HIV Nef shares sequence and structural features with scorpion peptides known to interact with K+ channels. Sequence similarity encompasses two distinct regions of scorpion peptides. Based on crystallography data, both regions in scorpion peptides cooperate in forming a common domain stabilized by ion pairs between charged amino-acid residues. Recombinant Nef protein, as well as a synthetic part of a scorpion channel active peptide (M10), reversibly increased the total K+ current of chick dorsal root ganglions in patch-clamp experiments without killing the cells. These results indicate that a region conserved in HIV Nef and scorpion peptides concurs in both structure and electrophysiological activity and suggest that Nef, like scorpion peptides, may affect neuronal cell function.
ULA-OP: an advanced open platform for ultrasound research (2009)

The experimental test of novel ultrasound (US) investigation methods can be made difficult by the lack of flexibility of commercial US machines. In the best options, these only provide beamformed radiofrequency or demodulated echo-signals for acquisition by an external PC. More flexibility is achieved in high-level research platforms, but these are typically characterized by high cost and large size. This paper presents a powerful but portable US system, specifically developed for research purposes. The system design has been based on high-level commercial integrated circuits to obtain the maximum flexibility and wide data access with minimum of electronics. Preliminary applications involving nonstandard imaging transmit/receive strategies and simultaneous B-mode and multigate spectral Doppler mode are discussed.
Protein synthesis, cellular amino acids, and energy levels in CAPD patients. (1987)

Cellular energy-related bioactivities [energy charge = ATP + 0.5 ADP/(ATP + ADP + AMP)], enzyme activities adenylate kinase, pyruvate kinase, phosphofructokinase, glucose-6-phosphate dehydrogenase, free amino acids in plasma and cells, and protein synthesis (3H-leucine incorporation) were measured in granulocytes isolated from peripheral blood of 13 CAPD-treated adult patients. The values were compared with 37 normal adult controls, 29 of whom had complete data for all biochemical parameters. Eleven of the CAPD patients were studied a second time, 3 to 8 months after the first study. Initially, after 20 +/- 8 months of CAPD compared (P less than 0.05, only) to controls, the patients had normal or increased activities of the enzymes pyruvate kinase, phosphofructokinase, glucose-6-phosphate dehydrogenase, in contrast to previous results from hemodialyzed patients; but adenylate kinase, ATP, and protein synthesis were reduced. Concentrations of many amino acids in plasma were abnormal, including reduced valine, leucine, threonine, tryptophan, and tyrosine, as noted by others. Histidine, glutamic acid, and citrulline especially were increased. The intracellular concentrations of the essential amino acids were within normal limits, but citrulline, glycine, and taurine levels were markedly increased while glutamic acid and SAGN (serine + asparagine + glutamine) were decreased. With the second study, intracellular energy-related bioactivities and the abnormal concentrations of the amino acids in plasma were essentially unchanged. However, virtually all the intracellular amino acid concentrations were higher. These results also were in striking contrast to previously reported hemodialysis patients in whom the intracellular concentrations of the branched-chain amino acids and methionine as well as protein synthesis were strikingly decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22 (2013)

Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22 and the BCR by a nanoparticle displaying both Ag and CD22 ligands induces a tolerogenic circuit resulting in apoptosis of the Ag-reactive B cell. Whether Siglec-G also has this property has not been investigated in large part owing to the lack of a selective Siglec-G ligand. In this article, we report the development of a selective high-affinity ligand for Siglec-G and its application as a chemical tool to investigate the tolerogenic potential of Siglec-G. We find that liposomal nanoparticles decorated with Ag and Siglec-G ligand inhibit BCR signaling in both B1 and B2 B cells compared with liposomes displaying Ag alone. Not only is inhibition of B cell activation observed by ligating the BCR with Siglec-G, but robust tolerance toward T-independent and T-dependent Ags is also induced in mice. The ability of Siglec-G to inhibit B cell activation equally in both B1 and B2 subsets is consistent with our observation that Siglec-G is expressed at a relatively constant level throughout numerous B cell subsets. These results suggest that Siglec-G may contribute to maintenance of B cell tolerance toward self Ags in various B cell compartments.
Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges (2015)

Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.
Simultaneous inversion of prestack seismic data for rock properties using a global simulated annealing (2002)

Abstract A new prestack inversion algorithm has been developed to simultaneously estimate acoustic and shear impedances from P-wave reflection seismic data. The algorithm uses a global optimization procedure in the form of simulated annealing. The goal of optimization is to find a global minimum of the objective function, which includes the misfit between synthetic and observed prestack seismic data. During the iterative inversion process, the acoustic and shear impedance models are randomly perturbed, and the synthetic seismic data are calculated and compared with the observed seismic data. To increase stability, constraints have been built into the inversion algorithm, using the low-frequency impedance and background Vs/Vp models. The inversion method has been successfully applied to synthetic and field data examples to produce acoustic and shear impedances comparable to log data of similar bandwidth. The estimated acoustic and shear impedances can be combined to derive other elastic parameters, which may be used for identifying of lithology and fluid content of reservoirs.
Assembly of Organosolv Lignin Residues into Submicron Spheres: The Effects of Granulating in Ethanol/Water Mixtures and Homogenization (2017)

The production of chemicals and various materials from black liquor lignin will greatly improve the economics of biomass refining. In the present work, organosolv lignin residues (OLRs) from the organosolv pulping process were used to fabricate submicron lignin spheres using ethanol/water mixtures as an antisolvent, in conjunction with homogenization. Both the ethanol content in the ethanol/water mixture and the applications of homogenization were investigated as key factors affecting the agglomeration of OLRs. The results show that the solubility of the amphiphilic OLRs in ethanol was approximately 28 and 32 times greater than those of alkali lignin and kraft lignin, respectively. Using the optimal percentage of ethanol together with homogenization enhanced the nucleation of lignin macromolecules, such that the colloidal spheres of OLR were spontaneously assembled via gradual hydrophilic-lipophilic aggregation. The resulting OLR colloidal spheres had a yolk-shell structure and a mean particle diameter of around 200 nm, when the ethanol content was 50% and the homogenization time was 15 min or more. This study demonstrates a simple means of utilizing OLRs to produce lignin-based spheres. The lignin spheres generated in this work are thought to have potential applications in many fields as porous carbon precursors for energy storage, sensitive functional materials, and controlled-release fertilizer carriers.
Effect of ciliates on nitrification and nitrifying bacteria in Baltic Sea sediments (2007)

Nitrification in aquatic sediments is catalyzed by bacteria. While many autecological studies on these bacteria have been published, few have regarded them as part of the benthic microbial food web. Ciliates are important as grazers on bacteria, but also for remineralization of organic matter. We tested the hypothesis that ciliates can affect nitrification. Experiments with Baltic Sea sediments in laboratory flumes, with or without the addition of cultured ciliates, were conducted. We found indication of a higher nitrification potential (ammonium oxidation) in one experiment and increased abundances of nitrifying bacteria in treatments with ciliates. This is likely due to higher nitrogen availability caused by excretion by ciliates and enhanced transport processes in the sediment.