gebhart/patrepeval huggingface dataset:
Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli (2016)

High glucose‑induced endothelial cell apoptosis is considered to be the initiator of diabetes‑associated vascular complications. Experiments in vivo and in vitro have demonstrated that high glucose levels contribute to the apoptosis of endothelial cells by mediating cellular dysfunction and metabolic disorder via the production of various cytokines. As the most important endogenous vascular regulators, the balance between pro‑proliferative effector vascular endothelial growth factor (VEGF) and anti‑proliferative effector tumor necrosis factor‑like cytokine 1A (TL1A) is important in the modulation of endothelial cell survival and proliferation, and neovascularization. The present study aimed to explore whether the imbalance between VEGF and TL1A affected the apoptosis of human umbilical vein endothelial cells (HUVECs) exposed to high glucose conditions and then further investigated the potential mechanism. The results showed that the downregulation of VEGF in combination with the upregulation of TL1A in response to high glucose levels led to enhanced HUVEC apoptosis. Further experiments revealed that silencing high glucose‑induced TL1A expression using TL1A small interfering (si)RNA or the overexpression of VEGF by transfection with VEGF DNA resulted in a reduced HUVEC apoptosis rate compared with the controls. The effects occurred by attenuating and activating the phosphoinositide 3‑kinase/Akt/endothelial nitric oxide synthase pathway, respectively. In addition, VEGF and TL1A inhibited each other in hyperglycemia. In conclusion, these findings provide theoretical support for the further investigation of novel therapeutic strategies designed to maintain the balance between VEGF and TL1A and, thus, to prevent the onset and progression of endothelial cell apoptosis in response to high glucose stimuli.
CD277 is a Negative Co-stimulatory Molecule Universally Expressed by Ovarian Cancer Microenvironmental Cells (2010)

CD277, a member of the butyrophilin subfamily 3 (BTN3), shares significant sequence similarities and predicted common structural features with inhibitory B7-H4 and other members of the B7 superfamily. Here we report that CD277 is consistently expressed in stromal, as well as tumor cells in the microenvironment of human advanced ovarian carcinoma specimens, both of primary and metastatic origin. MHC-II+ myeloid antigenpresenting leukocytes (dendritic cells and macrophages) express significantly higher levels of surface CD277, compared to other tumor-infiltrating leukocyte subsets, and this expression is significantly up-regulated by multiple common tumor microenvironmental signals, including VEGF and CCL3. Most importantly, engagement of CD277 on the surface of TCR-stimulated T cells inhibits their otherwise robust expansion and production of Th1 cytokines by preventing the up-regulation of cFLIP. Our results point to a role for CD277 up-regulated by microenvironmental signals in the acquisition of a regulatory phenotype by tumor-associated myeloid cells. Consequently, CD277, and likely other butyrophilins and butyrophilin-like molecules, emerge as regular players in the orchestration of immunosuppressive networks in ovarian cancer, and therefore new targets for interventions to overcome immune evasion and boost anti-tumor immunity in cancer patients.
Evaluation of polymeric films for buccal drug delivery. (2009)

The objective of this study was to evaluate the suitability of the bioadhesive polymers Carbopol 981 NF, Carbopol 1382 and sodium alginate as possible carriers for films for buccal drug delivery. Films were prepared by casting and solvent evaporation method, using propylene glycol as plasticizer and hydoxypropylmethyl cellulose to modify the properties of the films. The bioadhesive and mechanical properties of the films were evaluated with a TA-XT2i Texture Analyser. The alginate films exhibited greater bioadhesion and showed higher tensile strength and elasticity than the Carbopol films. There was a marked difference in the way the polymeric films hydrated in simulated saliva solution. Upon swelling the diameter of the alginate films did not increase but their thickness increases slightly, however the surface area of the Carbopol films increased significantly which points to them being unsuitable for drug delivery to the buccal mucosa. Excessive hydration of a polymeric film for buccal delivery could lead to decreasing adhesive strength and possibly loss of adhesion and hence shorter duration of retention. HPMC appeared to improve the properties of the films, affecting the bioadhesiveness and increasing tensile strength. For the alginate films an increase in HPMC leads to an increase in elasticity but for the Carbopol polymers this was not the case. The release profile of a model drug, sumatriptan succinate, showed that drug release was by diffusion rather than due to disintegration of the films. The results indicate that sodium alginate may be a suitable carrier for polymeric films for use in the buccal cavity.
A gate-oxide-breakdown antifuse OTP ROM array based on TSMC 90nm process (2015)

A one-time programmable (OTP) antifuse ROM array using MOSFET gate oxide breakdown, which is designed and fabricated under TSMC 90nm standard CMOS process, is presented in this paper. The breakdown voltage and breakdown time are measured. The schematic design of three-transistor antifuse OTP ROM array is exhibited. SPI bus is used to decrease the number of chip pads in practice. The experimental result shows that write & read function can be realized successfully.
Cyclizations of 5-Hexenyl, 6-Heptenyl, 7-Octenyl, and 8-Nonenyl Radicals. The Kinetic and Regiochemical Impact of Fluorine and Oxygen Substituents (1999)

Using competition kinetic methodology, rate constants for cyclizations of a series of hydrofluorocarbon (HFC) and ether 5-hexenyl, 6-heptenyl, and 7-octenyl radicals have been determined. Remarkably large rate constants (>107 s-1) have been observed for 6-exo-cyclizations of 1,1,2,2-tetrafluoro- and 1,1,2,2,3,3,4,4,-octafluoro-6-heptenyl radicals (>103 those of analogous hydrocarbon radicals), whereas HFC hexenyl and heptenyl ethers exhibit lower cyclization reactivity, as do HFC 7-octenyl radical systems, which cyclize in an endo manner. HFC 8-nonenyl radicals were not observed to cyclize. The results can be rationalized in terms of transition state polar influences, though other factors may also play significant roles.
Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane (1988)

Cathepsins B and L were purified from human kidney. SDS/polyacrylamide-gel electrophoresis demonstrated that cathepsins B and L, Mr 27000-30000, consist of disulphide-linked dimers, subunit Mr values 22000-25000 and 5000-7000. The pH optimum for the hydrolysis of methylcoumarylamide (-NHMec) substrates (see below) is approx. 6.0 for each enzyme. Km and kcat. are 252 microM and 364s-1 and 2.2 microM and 25.8 s-1 for the hydrolysis of Z-Phe-Arg-NHMec (where Z- represents benzyloxycarbonyl-) by cathepsins B and L respectively, and 184 microM and 158 s-1 for the hydrolysis of Z-Arg-Arg-NHMec by cathepsin B. A 10 min preincubation of cathepsin B (40 degrees C) or cathepsin L (30 degrees C) with E-64 (2.5 microM) results in complete inhibition. Under identical conditions Z-Phe-Phe-CHN2 (0.56 microM) completely inhibits cathepsin L but has little effect on cathepsin B. Incubation of glomerular basement membrane (GBM) with purified human kidney cathepsin L resulted in dose-dependent (10-40 nM) GBM degradation. In contrast, little degradation of GBM (less than 4.0%) was observed with cathepsin B. The pH optimum for GBM degradation by cathepsin L was 3.5. Cathepsin L was significantly more active in degrading GBM than was pancreatic elastase, trypsin or bacterial collagenase. These data suggest that cathepsin L may participate in the lysosomal degradation of GBM associated with normal GBM turnover in vivo.
Energy efficient proactive thermal management in memory subsystem (2010)

Energy management of memory subsystem is challenging due to performance and thermal constraints. Big energy gains can be obtained by clustering memory accesses, however this also leads to a higher need for cooling due to larger temperatures in active areas of memory. Our solution to memory thermal management problem is based on proactive thermal management that intelligently allocates workload pages to few memory units and powers down rest of the memory. Our experimental results show that this approach improves energy savings by 43% and reduces performance overhead by 85% with respect to the state of the art polices.
A systematic review of the role of interleukin-17 and the interleukin-20 family in inflammatory allergic skin diseases (2016)

IL-17 as well as IL-22 seem to play a role in the pathogenesis of allergic skin diseases.
1998 ARRS President's Award. The potential of in vivo vascular tissue engineering for the treatment of vascular thrombosis: a preliminary report. American Roentgen Ray Society. (1998)

In vivo tissue engineering is a new paradigm in molecular medicine that is a viable alternative to conventional gene therapy and tissue engineering for the treatment of vascular thrombosis.
Preconditioning Of Microchannel Plate Stacks (1989)

A preconditioning scheme for the stabilization of microchannel plate (MCP) Z stacks has been developed. Vacuum baking of MCP Z stacks is shown to have little effect on the gain and pulse height distribution characteristics, but tends to increase the background event rate. The major outgassing components during baking are found to be H<sub>2</sub>, N<sub>2</sub>, H<sub>2</sub>O, and CO<sub>2</sub>. The MCP stack resistance is found to decrease as the temperature rises, and the temperature coefficient has been determined. Burn-in of MCP stacks is shown to cause a 3x to 10x decrease in gain and also results in minimization of the background event rate. The major outgassing components during burn-in are found to be H<sub>2</sub>, N<sub>2</sub>, and CO<sub>2</sub>. Stabilization of the MCP stacks has been achieved when 0.06 to 0.08 Coulomb cm<sup>-2</sup> have been extracted from the MCP stack output during burn-in.
Transgenic B lymphocytes expressing a human cold agglutinin escape tolerance following experimental infection of mice byMycoplasma pulmonis (2002)

Several microbial infections, including Mycoplasma pneumoniae respiratory infection, are capable, in man, of transiently inducing the expression of anti-red blood cell autoantibody called cold agglutinins (CA). To analyze the mechanisms by which immune tolerance is broken following a mycoplasma infection, we used transgenic mice expressing a pathogenic human CA, designated CA-GAS, specific for sialylated carbohydrates. In these mice peripheral deletion of autoreactive B lymphocytes and receptor editing, prevent the development of autoimmune hemolytic anemia. Experimental infections of transgenic mice with Mycoplasma pulmonis resulted in a high anti-mycoplasma antibody response (despite a severe B cell depletion at the onset of infection), and an important induction of serum CA concentrations, reaching in some mice pathological titers. Whereas in naïve mice, only a small percentage of CA-expressing cells could be detected, in infected mice, a majority of circulating B lymphocytes were large B220(-) cells, which expressed the transgenic immunoglobulin. Immunization of the transgenic mice with keyhole limpet hemocyanin and Freund's adjuvant, to nonspecifically stimulate the expression of the passenger transgenes, only moderately increased the CA titers. These results indicate that M. pulmonis infection is capable of breaking immune tolerance in the CA-transgenic mice, in part through specific activation of CA-expressing B lymphocytes. This experimental infection mimics the induction of CA in humans and provide an animal model for studying the genesis of the autoimmune hemolytic anemia.
The Inherent Power to Impose Sanctions: How a Federal Judge is Like an 800-pound Gorilla (1994)

Debate over sanctions has captured the attention of the legal profession following each Rule 11 amendment. Curiously, there are no Goldilocks who find the Rule "just right"; everyone complains that it is either too strong or too weak. But in a significant sense, all the debate and controversy is beside the point. Suppose that someone said that a federal judge has the power to impose sanctions without the authority of Rule 11 and would have the 'power even if Rule 11 were abolished? Professor Baker seeks to answer this question by plumbing the depths of the inherent power of federal courts to sanction litigants.
Degradation and Transformation of Aquatic Humic Substances by Laccase-producing FungiCladosporium cladosporioides andPolyporus versicolor (1998)

A phenoloxidase-producing fungus – Cladosporium cladosporioides – was isolated from water of a bog lake. At high concentrations of carbon (333 mM) and nitrogen (12 mM), the fungus demonstrated the formation of a laccase and a high ligninolytic activity. After addition of riverine or groundwater humic substances into culture media (ca. 1 mg mL–1), the fungus showed the ability of degrading (utilizing) of about 60% of these substances. However, the exact quantification of the degree of degradation was difficult because of adsorption of humic matter on fungal mycelium. Reisolated humic substances were lower in aromatic and higher in aliphatic structures. A crude enzyme from the C. cladosporioides culture showed only low activity in decolorizing humic substances, whereas decolorization up to 50% was observed when using a laccase preparation from Polyporus versicolor, and especially in the presence of a redox mediator. Abbau und Umwandlung von aquatischen Huminstoffen durch die Laccase-bildenden Pilze Cladosporium cladosporioides und Polyporus versicolor Aus dem Wasser eines Moorsees wurde ein Phenoloxidase-bildender Pilz – Cladosporium cladosporioides – isoliert. Bei hohen Konzentrationen von Kohlenstoff (333 mmol L–1) und Stickstoff (12 mmol L–1) konnte bei dem Pilz die Bildung von Laccase und eine hohe ligninolytische Aktivität nachgewiesen werden. Bei Zugabe von Huminstoffen aus Fluß- und Grundwasser in das Kulturmedium (ca. 1 mg mL–1) bewirkte der Pilz einen Abbau von ca. 60% und eine strukturelle Veränderung der Huminstoffe. Allerdings war die Bilanzierung des Huminstoffabbaus durch die teilweise Adsorption dieser Substanzen an das Pilzmycel erschwert. Die reisolierten Huminstoffe wiesen eine niedrigere Aromatizität und einen erhöhten Anteil aliphatischer Strukturen auf. Ein aus der Kultur von C. cladosporioides gewonnenes Enzympräparat zeigte nur schwache Aktivität bei der Entfärbung von Huminstoffen. Ein Laccase-Präparat aus Polyporus versicolor bewirkte dagegen eine ca. 50%ige Entfärbung aquatischer Huminstoffe.
How to create “Name” (2011)

韓国や日本ではマンガの特性を活かした創作手法の提案や制作工程の効率化が強く望まれている．特にマンガのストーリー構成とネーム制作手法の提案がマンガの質の向上と制作の効率化のために重要である．この課題を解決するために，本研究ではストーリーマンガ制作のための段階的なネーム構成支援手法を提案することを目的とする．このために，まず，ストーリー制作の初期段階からネーム制作段階までを分析し，その制作手順を明らかにする．そして，ストーリーとネームの構成要素を用いて，段階的なストーリー構成とネーム構成手法を提案する．さらにこの提案手法で用いる効率的な制作情報管理のためのシーン設定テンプレートとページ設定支援テンプレートを考案する．最後に，本研究の提案手法とテンプレートを用い，マンガ制作実験を行った．その結果，本手法の有効性が確認できた．
The Fc‐alpha receptor is a new target antigen for immunotherapy of myeloid leukemia (2015)

Antibody-based immunotherapy of leukemia requires the targeting of specific antigens on the surface of blasts. The Fc gamma receptor (CD64) has been investigated in detail, and CD64-targeting immunotherapy has shown promising efficacy in the targeted ablation of acute myeloid leukemia (AML), acute myelomonocytic leukemia (AMML) and chronic myeloid leukemia cells (CML). Here we investigate for the first time the potential of FcαRI (CD89) as a new target antigen expressed by different myeloid leukemic cell populations. For specific targeting and killing, we generated a recombinant fusion protein comprising an anti-human CD89 single-chain Fragment variable and the well-characterized truncated version of the potent Pseudomonas aeruginosa exotoxin A (ETA'). Our novel therapeutic approach achieved in vitro EC50 values in range 0.2-3 nM depending on the applied stimuli, that is, interferon gamma or tumor necrosis factor alpha. We also observed a dose-dependent apoptosis-mediated cytotoxicity, which resulted in the elimination of up to 90% of the target cells within 72 hr. These findings were also confirmed ex vivo using leukemic primary cells from peripheral blood samples of three previously untreated patients. We conclude that CD89-specific targeting of leukemia cell lines can be achieved in vitro and that the efficient elimination of leukemic primary cells supports the potential of CD89-ETA' as a potent, novel immunotherapeutic agent.
The world of Shakespeare's sonnets: an introduction (2008)

Of Shakespeare's sonnets we know and appreciate many details - the crystalline meter, the exquisite diction, the exhilarating surprise of the turn in the final couplet. By contrast, we know very little of their subjects and motives. For this reason, this book does not approach the sonnets as Shakespearean autobiography. Instead, it delineates the customs and beliefs that shaped the sonnets, Shakespeare's life, and his world, and considers them in that context. Departing from the traditional rhapsodizing over the sonnets as timeless expressions of love, this book argues for understanding the sonnets in their time, as this consummate poet's brilliant, edgy expression of the equally brilliant, edgy culture of the English Renaissance.
A Novel Form of Diffusion Battery (1975)

A novel form of diffusion battery uses a series of 635-mesh screens instead of the customary cluster of circular tubes or holes. Fifty-five screens are arranged in series so that the amount of aerosol penetrating through different numbers of screens can be measured with a condensation nuclei counter. This "filter stack" must be calibrated because theory is not available to calculate the performance of such screens with sufficient accuracy. For calibration a polydisperse aerosol such as ambient or silver aerosol is used to compare the performance of the screens with that of the cluster-tube and collimated-holes diffusion batteries, whose performance is known from theory. It was observed that a given number of screens is equivalent to a given number of batteries independent of the size or size distribution of the aerosol. This filter stack is very compact and light in weight (0.9 kg). It is particularly useful for measurements in the field.
Predicting total build‐time and the resultant cure depth of the 3D stereolithography process (1996)

Accurate build‐time prediction for making stereolithography parts not only benefits the service industry with information necessary for correct pricing and effective job scheduling, it also provides researchers with valuable information for various build parameter studies. Instead of the conventional methods of predicting build time based on the part’s volume and surface, the present predictor uses the detailed scan and recoat information from the actual build files by incorporating the algorithms derived from a detailed study of the laser scan mechanism of the stereolithography machine. Finds that the scan velocity generated from the stereolithography machine depends primarily on the system’s laser power, beam diameter, materials properties and the user’s specification of cure depth. Proves that this velocity is independent of the direction the laser travels, and does not depend on the total number of segments of the scan path. In addition, the time required for the laser to jump from one spot to another without scan is linearly proportional to the total jump distance, and can be calculated by a proposed constant velocity. Most profoundly, the present investigation concludes that the machine uses a velocity factor which is only 68.5 per cent of the theoretical calculation. This much slower velocity results in an undesired amount of additional cure and proves to be the main cause of the Z dimensional inaccuracy. The present build‐time predictor was developed by taking into account all the factors stated above, and its accuracy was further verified by comparing the actual build‐time observed for many jobs over a six month period.
Control-data separation in cloud RAN: The case of uplink HARQ (2016)

The performance of uplink HARQ in a Cloud-Radio Access Network (C-RAN) architecture is limited by the two-way latency on the fronthaul links connecting the Remote Radio Heads (RRHs) with the Baseband Unit (BBU) that performs decoding. In order to alleviate this problem, this work considers an alternative architecture based on the separation of control and data planes, in which the control plane is implemented at the edge, namely at the RRHs and at the User Equipments (UEs), while data decoding is still carried out remotely at the BBU as in a conventional C-RAN. More specifically, the RRHs perform local uplink channel estimation and feed back low-rate information to the UEs, which then make low-latency local retransmission decisions. Retransmission control is hence not subject to the fronthaul latency constraints. “Hard” and “soft” local feedback schemes are presented. The analysis, which is based on finite-blocklength bounds, allows the optimization of the considered schemes, as well as the investigation of the impact of system parameters such as blocklength and number of feedback bits on the performance of the proposed architecture.
Three-dimensional facial recognition using passive long-wavelength infrared polarimetric imaging (2014)

We use a polarimetric camera to record the Stokes parameters and the degree of linear polarization of long-wavelength infrared radiation emitted by human faces. These Stokes images are combined with Fresnel relations to extract the surface normal at each pixel. Integrating over these surface normals yields a three-dimensional facial image. One major difficulty of this technique is that the normal vectors determined from the polarizations are not unique. We overcome this problem by introducing an additional boundary condition on the subject. The major sources of error in producing inversions are noise in the images caused by scattering of the background signal and the ambiguity in determining the surface normals from the Fresnel coefficients.
Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia (2006)

The new algorithm is a highly accurate tool for correctly diagnosing the cause of WCT ECGs.
A Feature Selection and Evaluation Scheme for Computer Virus Detection (2006)

Anti-virus systems traditionally use signatures to detect malicious executables, but signatures are over-fitted features that are of little use in machine learning. Other more heuristic methods seek to utilize more general features, with some degree of success. In this paper, we present a data mining approach that conducts an exhaustive feature search on a set of computer viruses and strives to obviate over-fitting. We also evaluate the predictive power of a classifier by taking into account dependence relationships that exist between viruses, and we show that our classifier yields high detection rates and can be expected to perform as well in real-world conditions.
"I am a Bookman." (1942)

Journal Article "I am a Bookman." Get access A. E. D. A. E. D. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 182, Issue 23, 6 July 1942, Page 317, https://doi.org/10.1093/nq/182.23.317g Published: 06 July 1942