gebhart/patrepeval huggingface dataset:
A Low-Cost Point-of-Care Testing System for Psychomotor Symptoms of Depression Affecting Standing Balance: A Preliminary Study in India (2013)

The World Health Organization estimated that major depression is the fourth most significant cause of disability worldwide for people aged 65 and older, where depressed older adults reported decreased independence, poor health, poor quality of life, functional decline, disability, and increased chronic medical problems. Therefore, the objectives of this study were (1) to develop a low-cost point-of-care testing system for psychomotor symptoms of depression and (2) to evaluate the system in community dwelling elderly in India. The preliminary results from the cross-sectional study showed a significant negative linear correlation between balance and depression. Here, monitoring quantitative electroencephalography along with the center of pressure for cued response time during functional reach tasks may provide insights into the psychomotor symptoms of depression where average slope of the Theta-Alpha power ratio versus average slope of baseline-normalized response time may be a candidate biomarker, which remains to be evaluated in our future clinical studies. Once validated, the biomarker can be used for monitoring the outcome of a comprehensive therapy program in conjunction with pharmacological interventions. Furthermore, the frequency of falls can be monitored with a mobile phone-based application where the propensity of falls during the periods of psychomotor symptoms of depression can be investigated further.
Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer Cells (1998)

Telomerase, a specialized RNA-directed DNA polymerase that extends telomeres of eukaryotic chromosomes, is repressed in human somatic tissues and becomes activated during tumor progression in most human cancers. To date, little is known about how telomerase is activated and controlled in cancer, although activation is thought to be involved in cancer cell immortalization. Here, we report that human telomerase-associated protein 1 (hTEP1) and the telomerase catalytic subunit (human telomerase reverse transcriptase (hTERT)) are phosphoproteins and that their phosphorylation is a prerequisite for the activation of telomerase in intact human breast cancer cells. Identified by hTEP1 peptide affinity chromatography, protein kinase Calpha mediates the phosphorylation of hTEP1 and hTERT and induces a marked increase in telomerase activity. Thus, phosphorylation of hTEP1 and hTERT by protein kinase Calpha represents an essential step in the generation of a functional telomerase complex in the initiation and maintenance of telomerase activity in human cancer.
Screening of 25 compounds isolated from <i>Phyllanthus</i> species for anti‐human hepatitis B virus <i>in vitro</i> (2003)

Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb. and P. virgatus Forst. f. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 micro m, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).
5, 5″‐Bis{4‐[bis(4‐methylphenyl)amino]phenyl}2, 2′:5′, 2″‐terthiophene and 5, 5‴‐bis{4‐[Bis(4‐methylphenyl)amino]phenyl}2, 2′:5′, 2″:5″, 2‴‐quaterthiophene as a Novel Family of Amorphous Molecular Materials (1997)

A novel family of photo‐and electroactive amorphous molecular materials containing an oligothiophene moiety linked to two triphenylamine moieties has been designed and synthesized (see Figure). Their glass‐forming properties, morphological changes, and molecualr and solid‐state properties are described. They are reported to exhibit multiredox behavior on electrochemical oxidation. magnified image
L’Europe à la poursuite du rêve américain (2000)

Les perspectives de croissance européenne sont au premier semestre 2000 placées sous le signe de l’optimisme. Les points de vue exprimés lors de la réunion de printemps des économistes de l’Association des Instituts Européens de Conjoncture Economique (AIECE) à Ljubljana en sont le reflet : par rapport à l’automne dernier, les croissances prévues ont été révisées en hausse. Pour l’ensemble de l’Union européenne, elles sont maintenant de 3,2 % pour 2000 (au lieu de 2,6 en automne) et 3,0 % pour 2001 (1). L’Irlande devrait à nouveau recevoir la palme de la plus forte croissance de la zone, suivie de la Finlande, des Pays-Bas et de la France, l’Italie, l’Allemagne et le Danemark restant les derniers du classement (tableau). Chez nos voisins d’Europe centrale, les perspectives de croissance sont aussi plus favorables qu’il y a six mois (...).
Small Molecule Modulation of Proteasome Assembly (2018)

The 20S proteasome is the main protease that directly targets intrinsically disordered proteins (IDPs) for proteolytic degradation. Mutations, oxidative stress, or aging can induce the buildup of IDPs resulting in incorrect signaling or aggregation, associated with the pathogenesis of many cancers and neurodegenerative diseases. Drugs that facilitate 20S-mediated proteolysis therefore have many potential therapeutic applications. We report herein the modulation of proteasome assembly by the small molecule TCH-165, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs, including α-synuclein, tau, ornithine decarboxylase, and c-Fos, but not structured proteins. Clearance of ubiquitinated protein was largely maintained by single capped proteasome complexes (19S-20S), but accumulation occurs when all 19S capped proteasome complexes are depleted. This study illustrates the first example of a small molecule capable of targeting disordered proteins for degradation by regulating the dynamic equilibrium between different proteasome complexes.
The American Revolution Considered as a Social Movement (1941)

The American Revolution Considered as a Social Movement. By J. Franklin Jameson. (Princeton : Princeton University Press, 1940. viii + 100 pp. $1.75.) Get access Merle Curti Merle Curti Columbia University Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 28, Issue 2, September 1941, Pages 257–258, https://doi.org/10.2307/1896230 Published: 01 September 1941
A novel nickel-containing superoxide dismutase from <i>Streptomyces</i> spp (1996)

A novel type of superoxide dismutase (SOD) was purified to apparent homogeneity from the cytosolic fractions of Streptomyces sp. IMSNU-1 and Strep. coelicolor ATCC 10147 respectively. Both enzymes were composed of four identical subunits of 13.4 kDa, were stable at pH 4.0-8.0 and up to 70 degrees C, and were inhibited by cyanide and H2O2 but little inhibited by azide. The atomic absorption analyses revealed that both enzymes contain 0.74 g-atom of nickel per mol of subunit. Both enzymes were different from iron-containing SOD and manganese-containing SOD from Escherichia coli, and copper- and zinc-containing SODs from Saccharomyces cerevisiae and bovine erythrocytes, with respect to amino acid composition, N-terminal amino acid sequence and cross-reactivity against antibody. The absorption spectra of both enzymes were identical, exhibiting maxima at 276 and 378 nm, and a broad peak at 531 nm. The EPR spectra of both enzymes were almost identical with that of NiIII in a tetragonal symmetry of NiIII-oligopeptides especially containing histidine. The apoenzymes, lacking in nickel, had no ability to mediate the conversion of superoxide anion radical to hydrogen peroxide, strongly indicating that NiIII plays a main role in these enzymes.
The Scattering of Low-Frequency Lattice Waves by Static Imperfections (1955)

The scattering of lattice waves by static imperfections is treated by second-order perturbation theory. The transition matrix is composed of contributions due to the mass difference of lattice points, changes in the elastic constants of linkages between lattice points, and elastic strain. Point imperfections are shown to scatter as the fourth power of frequency, dislocations as the first power, and grain boundaries independently of frequency. The magnitude of the scattering cross section is estimated for a variety of lattice defects in alkali halides, for screw and edge dislocations and for grain boundaries. These results are discussed in relation to thermal conduction by the lattice at low temperatures.
Pathology associated with <i>Edwardsiella ictaluri</i> in catfish, <i>Ictalurus punctatus</i> Rafinesque, and <i>Danio devario</i> (Hamilton‐Buchanan, 1822) (1985)

The pathology associated with infections of Edwardsiella ictaluri in a new host, the danio, is described and compared to that observed in the channel catfish. In catfish the acute stage was characterized by petechial haemorrhage of the jaw, ventral body surface, and at the base of the fins. In chronic cases a characteristic finding was an erosion of skin and muscle overlying the skull, exposing bone and occasionally the brain. Histologically there was a diffuse granulomatous inflammation of the olfactory bulb and the telencephalon. In the catfish the infection was often systemic, involving intestine, liver, spleen, and occasionally kidney. In the danio no gross lesions were observed. Infected fish exhibited an erratic, spinning‐type swimming behaviour. Histologically, lesions usually were confined to the brain. They consisted of an acute, primarily granulocytic inflammation of the medulla oblongata (rhomboencephalon). Only one fish showed evidence of a systemic infection.
Silicon Nitride Single-Layer X-Ray Mask (1981)

In the low pressure chemical vapor deposition process, preparation of silicon nitride with low film stress and low refractive index is investigated as a function of deposition temperature and reactant gas ratio SiH 2 Cl 2 /NH 3 . The silicon nitride film with a stress of 15 kg/mm 2 and refractive index of 2.3 is formed at the deposition temperature of 850°C and the SiH 2 Cl 2 /NH 3 ratio of 4/1. Using the film as an X-ray mask, a silicon nitride single-layer X-ray mask is realized, which has a 30 ×30 mm window and has high transparency to visible light.
Arginine Vasopressin Levels Are Elevated and Correlate With Functional Status in Infants and Children With Congestive Heart Failure (2004)

Arginine vasopressin levels are elevated in infants and children with CHF attributable to left ventricular dysfunction and in infants with large left-to-right intracardiac shunts. Furthermore, there is a direct relationship between AVP level and the severity of heart failure in patients with DCM.
Photochemistry of Ketone Polymers. VII. Polymers and Copolymers of Phenyl Vinyl Ketone (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of Ketone Polymers. VII. Polymers and Copolymers of Phenyl Vinyl KetoneF. J. Golemba and J. E. GuilletCite this: Macromolecules 1972, 5, 2, 212–216Publication Date (Print):March 1, 1972Publication History Published online1 May 2002Published inissue 1 March 1972https://doi.org/10.1021/ma60026a021RIGHTS & PERMISSIONSArticle Views374Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (569 KB) Get e-Alertsclose Get e-Alerts
Dama Romana de Baelo Claudia (2010)

La estrecha colaboracion que se mantiene entre las instituciones, -Conjunto Arqueologico de Baelo Claudia, Junta de Andalucia y el Ayuntamiento de Tarifa-, ha vuelto a ser claramente materializada en la reproduccion, por el equipo de restauradores del citado Conjunto, de una bella escultura femenina romana en marmol de epoca alto imperial, actualmente expuesta al publico frente a la Puerta de Jerez. Al objeto de que la contemplacion y deleite de tan interesante talla de la antiguedad vaya renida al conocimiento tecnico e historico de tarifenos y vecinos en general, nos planteamos la redaccion de este trabajo, a su descripcion artistica y contextualizacion historico-arqueologica, en un intento, nada facil, de aproximacion al programa escultorico de caracter politico y religioso que desarrollo el prospero municipio romano a orillas del estrecho de Gibraltar.
ECONOMICAL STORAGE OF OIL AND GAS PROMISED BY CONSTRUCTING UNDERGROUND STORAGE FACILITIES WITH NUCLEAR EXPLOSIONS (1959)

The author concludes that application of underground nuclear bursts for blasting out huge underground storage cavities for oil and gas storage is not only technically .H,)
ChemInform Abstract: Antiinflammatory Eunicellin‐Based Diterpenoids from the Cultured Soft Coral Klyxum simplex (2010)

Abstract isolation, structure elucidation and antiinflammatory activity of klysimplexin sulfoxides A (I), B (II), and C (III)
Eicosapentaenoic acid (20∶5n‐3) from the marine microalga<i>Phaeodactylum tricornutum</i> (1996)

Abstract Eicosapentaenoic acid (EPA, 20∶5n‐3) was obtained from the marine microalgae Phaeodactylum tricornutum by a three‐step process: fatty acid extraction by direct saponification of biomass, polyunsaturated fatty acid (PUFA) concentration by formation of urea inclusion compounds, and EPA isolation by semipreparative high‐performance liquid chromatography (HPLC). Alternatively, EPA was obtained by a similar two‐step process without the PUFA concentration step by the urea method. Direct saponification of biomass was carried out with two solvents that contained KOH for lipid saponification. An increase in yield was obtained because the problems associated with emulsion formation were avoided by separating the biomass from the soap solution before adding hexane for extraction of insaponifiables. The most efficient solvent, ethanol (96%) at 60°C for 1 h, extracted 98.3% of EPA. PUFA were concentrated by the urea method with a urea/fatty acid ratio of 4∶1 at a crystallization temperature of 28°C and by using methanol and ethanol as urea solvents. An EPA concentration ratio of 1.73 (55.2∶31.9) and a recover yield of 78.6% were obtained with methanol as the urea solvent. This PUFA concentrate was used to obtain 93.4% pure EPA by semipreparative HPLC with a reverse‐phase, C 18 , 10 mm i.d.×25‐cm column and methanol/water (1% acetic acid), 80∶20 w/w, as the mobile phase. Eighty‐five percent of EPA loaded was recovered, and 65.7% of EPA present in P. tricornutum biomass was recovered in highly pure form by this three‐step downstream process. Alternatively, 93.6% pure EPA was isolated from the fatty acid extract (without the PUFA concentration step) with 100% EPA recovery yield. This two‐step process increases the overall EPA yield to 98.3%, but it is only possible to obtain 20% as much EPA as that obtained by three‐step downstream processing.
NLOS error mitigation in mobile location based on modified extended Kalman filter (2012)

Geolocation and tracking of mobile objects is an important issue in wireless communication networks. Various methods have been devised and implemented to deal with such problems whose performance is particularly limited in non-line-of-sight propagation conditions. In this paper, we take advantage of the extended Kalman filter with some extensions, modifications and improvement of previous work to reduce the NLOS error in the location measurement. One of the key contributions of this paper is to present the methods that discriminate the NLOS measurements from the LOS measurements based on the standard deviation and K-means clustering and reconstruct the LOS measurements out of the NLOS measurements by polynomial fit in order to mitigate the NLOS error. Simulation results confirm the effectiveness and accuracy of our approach in comparison with the conventional EKF algorithm. Moreover, we do not model the distribution of the NLOS error due to its intractability.
A High‐Performance Carbon for Supercapacitors Obtained by Carbonization of a Seaweed Biopolymer (2006)

An oxygen-rich carbon for supercapacitors has been obtained by one-step carbonization of a natural biopolymer from seaweeds, e.g., sodium alginate. Although the specific surface area of this carbon is very low, it gives a capacitance comparable to the best activated carbons available. Due to its low porosity (see figure), this material has high density and good electrical conductivity, also advantageous for supercapacitor applications.
Caged mitochondrial uncouplers that are released in response to hydrogen peroxide (2010)

Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (+/-0.8) M(-1) s(-1) and 64.8 (+/-0.6) M(-1) s(-1), respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.
Opioid Receptors and their Pharmacological Profiles (1992)

Opioid receptors can be divided into three major classes, which are called mu, delta and kappa-receptors. The molecular basis of the receptors is discussed and a hypothesis of the binding of bivalent ligands to the receptor is presented. Furthermore the mechanism of action, the distribution and the probable function of these classes is overviewed. Increasing evidence is accumulating that the classical binding model cannot explain completely the interaction of opioids with their receptors. In addition to the mu-receptors, high affinity mu 1 binding sites have been demonstrated. Similarly, the delta receptors may be divided in delta 1 and delta 2. The significance of these subclasses is not yet fully understood. The high affinity mu 1-binding sites, however, represent probably an activated receptor complex, e.g. the complex between the receptor and the guanine-nucleotide-binding protein.
Haploinsufficiency for Adrenomedullin Reduces Pinopodes and Diminishes Uterine Receptivity in Mice1 (2008)

Adrenomedullin (AM) is a multifunctional peptide vasodilator that signals through a G-protein-coupled receptor when the receptor, called calcitonin receptor-like receptor (CL), is associated with a receptor activity-modifying protein 2 (RAMP2). We demonstrated previously that haploinsufficieny for each of these genes led to reduced maternal fertility, and that even a modest genetic reduction of AM peptide caused maternal defects in implantation, placentation, and fetal growth. Here, we further demonstrate that Adm(+/-) female mice displayed reduced pregnancy success rates that were not caused by defects in folliculogenesis, ovulation, or fertilization. The poor fertility of Adm(+/-) female mice could not be rescued by transfer of wild-type blastocysts, which suggested an underlying defect in uterine receptivity. In fact, we found that Adm, Calcrl, and Ramp2 gene expressions are tightly and spatiotemporally regulated in the luminal epithelial cells of the uterus during the estrus cycle and the peri-implantation period. RAMP3, which also generates an AM receptor when associated with CL, had a diametrically opposite expression pattern than that of Adm, Calcrl, and Ramp2 and was most robustly induced in the stroma of the uterus. Finally, we discovered that Adm(+/-) female mice have a substantially reduced number of pinopodes on the uterine luminal epithelial surface, which is indicative and possibly causative of the poor uterine receptivity. Taken together, our studies identify a new class of pharmacologically tractable proteins that are involved in establishing uterine receptivity through the regulation of pinopode formation.
Generalized Multiprotocol Label Switching (GMPLS) User-Network Interface (UNI): Resource ReserVation Protocol-Traffic Engineering (RSVP-TE) Support for the Overlay Model (2005)

Generalized Multiprotocol Label Switching (GMPLS) defines both routing
and signaling protocols for the creation of Label Switched Paths
(LSPs) in various switching technologies. These protocols can be used
to support a number of deployment scenarios. This memo addresses the
application of GMPLS to the overlay model. [STANDARDS-TRACK]
Progress on the Investigation of Coal-Water Slurry Fuel Combustion in a Medium-Speed Diesel Engine: Part 5—Combustion Studies (1992)

In the GE 7FDL single-cylinder research diesel engine, coal-water slurry (CWS) fuel combustion optimization studies were conducted using electronically controlled CWS and pilot accumulator injectors. The most important performance parameters of peak firing pressure, combustion efficiency (coal burnout), and specific fuel comsumption were evaluated in relationship to CWS and pilot injection timing, CWS injector hole size, shape, and number, CWS fuel injection spray angles and injection pressure. Heat release diagrams, as well as exhaust samples (gaseous and particulate), were analyzed for each case. Interesting effects of fuel spray impingement and CWS fuel “Delayed Ignition” were observed. With the engine operating at 2.0 MPa IMEP and 1050 rpm, it was able to obtain over 99.5 percent combustion efficiency while holding the cylinder firing pressure below 17 MPa and thermal efficiency equivalent to diesel fuel operation.
Photoinduced Electron Transfer within Supramolecular Donor–Acceptor Peptide Nanostructures under Aqueous Conditions (2016)

We report the synthesis, self-assembly, and electron transfer capabilities of peptide-based electron donor-acceptor molecules and supramolecular nanostructures. These modified peptides contain π-conjugated oligothiophene electron donor cores that are peripherally substituted with naphthalene diimide electron acceptors installed via imidation of site-specific lysine residues. These molecules self-assemble into one-dimensional nanostructures in aqueous media, as shown through steady-state absorption, photoluminescence, and circular dichroism spectra, as well as transmission electron microscopy. Excitation of the oligothiophene donor moieties results in electron transfer to the acceptor units, ultimately creating polar, charge-separated states that persist for over a nanosecond as observed with transient absorption spectroscopy. This study demonstrates how transient electric fields can be engineered into aqueous nanomaterials of biomedical relevance through external, temporally controlled photonic inputs.