gebhart/patrepeval huggingface dataset:
Long-acting delivery systems for narcotic antagonists. 1 (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLong-acting delivery systems for narcotic antagonists. 1James H. R. Woodland, Seymour Yolles, David A. Blake, Martin Helrich, and Francis J. MeyerCite this: J. Med. Chem. 1973, 16, 8, 897–901Publication Date (Print):August 1, 1973Publication History Published online1 May 2002Published inissue 1 August 1973https://doi.org/10.1021/jm00266a007RIGHTS & PERMISSIONSArticle Views126Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (625 KB) Get e-Alerts Get e-Alerts
Human brain glucose metabolism mapping using multislice 2D1H-13C correlation HSQC spectroscopy (2000)

A method for multivolume 2D (1)H-(13)C correlation spectroscopy, multislice heteronuclear single quantum coherence (HSQC), is proposed. This permits human brain metabolism from glucose to amino acids to be followed using a 2-T whole-body scanner. The modifications from the conventional HSQC are that the 180 degrees ((13)C) and 180 degrees ((1)H) pulses are separated in time in the preparation period and that the 180 degrees ((13)C) pulse is applied at 1/(4J(CH)) before the 90 degrees ((1)H) polarization transfer (PT) pulse. The preparation (echo) time can be set longer than 1/(2J(CH)) so that, even in a whole-body system, slice-selective pulses and gradients can be applied. Another modification is that the 90 degrees ((1)H) reverse PT pulses after the creation of 2I(z)S(z) are used as multislice pulses. The time-course of glutamate C4 could be followed with 15-min temporal resolution from the HSQC spectra obtained from the brains of volunteers after the oral administration of glucose C1, and the maximum S/N was 3.
Impact of substituents on the enantioseparation of racemic 2-amidotetralins on polysaccharide stationary phases. I. chiralcel OD (1996)

The direct enantiomeric separation of 32 racemic 2-amidotetralins on the commercially available tris-(3,5-dimethylphenylcarbamate) derivative of cellulose, coated on silica gel (Chiralcel OD), is presented. To date, the selection of a column for the chiral separation of a racemic mixture is done empirically. Studying the impact of small changes in the chemical structure of a series of amidotetralins on the separation behavior may help to give an insight in the chiral recognition mechanism. The amidotetralins differed structurally in three of their substituents, which were never directly located on the chiral carbon atom. The enantiomers of 24 out of 32 amidotetralins could be resolved with a resolution >1.5. Hydrogen bonding and π-π interactions are supposed to be the major analyte-chiral stationary phase (CSP) interactions. However, the spatial arrangement of the enantiomers may play an important role too. Increasing the bulkiness of the acyl substituent led to an increase in the resolution (RS), whereas a more bulky substituent on the aromatic ring resulted in a very low resolution. The introduction of a chlorine atom into the acyl substituent additionally increased the resolving power. Chirality 8:574–578, 1996. © 1997 Wiley-Liss, Inc.
Ion Exchangers as Catalyst in Esterification Reaction: A Review (2018)

This review articles describe the use of ion exchange resins as catalyst in esterification reaction. Esterification is chemical process used for making esters. Esters are chemicals used in the flavours, fragrance, pharmaceutical and plastic industries. Different routes exist to manufacture esters but common route is homogenous acid catalyst are used. These catalyst having corrosion and pollution problems and also separation from reaction medium is difficult. To overcome these problem ion exchange resin (IER) are used as catalyst. Ion exchange is the reversible interchange of ions between a solid and a liquid in which no permanent change in structure of solid .These catalyst facilitated by recovery and recycle. Its reuse increases the productivity and cost effectiveness in esterification reactions. Due to easier workup, chemical industry has strong preference for ion exchange resin catalyst but these catalysts does not offer selectivity observed in homogenous catalyst and limitation of ion exchange resin is temperature except Nafion. These reviews discuss industrially important reactions. Various types of reactors employed for esterification reactions like batch reactors, fixed bed reactors/reactive chromatography (RC), simulated moving bed reactors has been discussed. Ion exchange catalyst moulded in different shapes which acts as catalyst and packing this can be useful in the reactive distillation (RD), which also incorporated
Synthesis of Cu Nanoparticles and Microsized Fibers by Using Carbon Nanotubes as a Template (1999)

Copper in the form of nanoparticles and microsized fibers was synthesized by using carbon nanotubes as a template. The size of the copper nanoparticles was controllable in the range between a few and tens of nanometers, depending on the diameter of carbon nanotubes and the preparation conditions. They could be detached from carbon nanotubes by ultrasonic treatment. Cu fibers with diameter ranging from 100 nm to several μm were obtained when increasing the amount of Cu coated onto carbon nanotubes, which in this case became undetectable under SEM and XRD observations. The electronic structure of these two forms of Cu materials was studied by XPS and UPS and compared with that of polycrystalline Cu metal. A negative core-level binding energy shift for Cu nanoparticles and an increase in work function for Cu fibers as compared with those of the polycrystalline Cu were observed and discussed in terms of size effect.
ChemInform Abstract: SYNTHESIS AND MAGNETIC PROPERTIES OF MANGANESE CHROMIUM BORIDE ((MN1‐XCRX)3B4) AND MANGANESE MOLYBDENUM BORIDE ((MN1‐XMOX)3B4) (1982)

Abstract Proben der Titelmischkristalle in den Zusammensetzungsbereichen 0 x 1 bzw. 0 x 0.8 werden unter Hochdruck‐Hochtemp‐Bedingungen (3.0 GPa, 1800‐1900°C, 10 bis 30 min) dargestellt und lassen sich durchweg als Strukturen vom Ta3B4‐Typ indizieren.
Dead-end Radical Polymerization (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDead-end Radical PolymerizationArthur V. TobolskyCite this: J. Am. Chem. Soc. 1958, 80, 22, 5927–5929Publication Date (Print):November 1, 1958Publication History Published online1 May 2002Published inissue 1 November 1958https://pubs.acs.org/doi/10.1021/ja01555a009https://doi.org/10.1021/ja01555a009research-articleACS PublicationsRequest reuse permissionsArticle Views530Altmetric-Citations179LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modular 32-channel transceiver coil array for cardiac MRI at 7.0T (2013)

The modular 32-channel transceiver cardiac array supports accelerated and high spatial resolution cardiac MRI. The array is compatible with multichannel transmission and provides a technological basis for future clinical assessment of parallel transmission techniques at 7.0T.
Maggot Therapy in “Lower-Extremity Hospice” Wound Care (2005)

We sought to assess, in a case-control model, the potential efficacy of maggot debridement therapy in 60 nonambulatory patients (mean +/- SD age, 72.2 +/- 6.8 years) with neuroischemic diabetic foot wounds (University of Texas grade C or D wounds below the malleoli) and peripheral vascular disease. Twenty-seven of these patients (45%) healed during 6 months of review. There was no significant difference in the proportion of patients healing in the maggot debridement therapy versus control group (57% versus 33%). Of patients who healed, time to healing was significantly shorter in the maggot therapy than in the control group (18.5 +/- 4.8 versus 22.4 +/- 4.4 weeks). Approximately one in five patients (22%) underwent a high-level (above-the-foot) amputation. Patients in the control group were three times as likely to undergo amputation (33% versus 10%). Although there was no significant difference in infection prevalence in patients undergoing maggot therapy versus controls (80% versus 60%), there were significantly more antibiotic-free days during follow-up in patients who received maggot therapy (126.8 +/- 30.3 versus 81.9 +/- 42.1 days). Maggot debridement therapy reduces short-term morbidity in nonambulatory patients with diabetic foot wounds.
Structural parameters governing activity of Pluronic triblock copolymers in hyperthermia cancer therapy (2011)

Pluronic copolymer structure properties including, Mw, HLB and PO length are essential to its hyperthermia sensitising function.
Constructions of Rank Modulation Codes (2012)

Rank modulation is a way of encoding information to correct errors in flash memory devices as well as impulse noise in transmission lines. Modeling rank modulation involves construction of packings of the space of permutations equipped with the Kendall tau distance. As our main set of results, we present several general constructions of codes in permutations that cover a broad range of code parameters. In particular, we show a number of ways in which conventional error-correcting codes can be modified to correct errors in the Kendall space. Our constructions are nonasymptotic and afford simple encoding and decoding algorithms of essentially the same complexity as required to correct errors in the Hamming metric. As an example, from binary Bose–Chaudhuri–Hocquenghem codes, we obtain codes correcting <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$t$</tex></formula> Kendall errors in <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$n$</tex></formula> memory cells that support the order of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$n!/(\log_{2}n!)^{t}$</tex></formula> messages, for any constant <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$t=1,2,\ldots$</tex></formula> . We give many examples of rank modulation codes with specific parameters. Turning to asymptotic analysis, we construct families of rank modulation codes that correct a number of errors that grows with <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$n$</tex></formula> at varying rates, from <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\Theta (n)$</tex></formula> to <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\Theta (n^{2})$</tex></formula> . One of our constructions gives rise to a family of rank modulation codes for which the tradeoff between the number of messages and the number of correctable Kendall errors approaches the optimal scaling rate.
Prophage Spontaneous Activation Promotes DNA Release Enhancing Biofilm Formation in Streptococcus pneumoniae (2010)

Streptococcus pneumoniae (pneumococcus) is able to form biofilms in vivo and previous studies propose that pneumococcal biofilms play a relevant role both in colonization and infection. Additionally, pneumococci recovered from human infections are characterized by a high prevalence of lysogenic bacteriophages (phages) residing quiescently in their host chromosome. We investigated a possible link between lysogeny and biofilm formation. Considering that extracellular DNA (eDNA) is a key factor in the biofilm matrix, we reasoned that prophage spontaneous activation with the consequent bacterial host lysis could provide a source of eDNA, enhancing pneumococcal biofilm development. Monitoring biofilm growth of lysogenic and non-lysogenic pneumococcal strains indicated that phage-infected bacteria are more proficient at forming biofilms, that is their biofilms are characterized by a higher biomass and cell viability. The presence of phage particles throughout the lysogenic strains biofilm development implicated prophage spontaneous induction in this effect. Analysis of lysogens deficient for phage lysin and the bacterial major autolysin revealed that the absence of either lytic activity impaired biofilm development and the addition of DNA restored the ability of mutant strains to form robust biofilms. These findings establish that limited phage-mediated host lysis of a fraction of the bacterial population, due to spontaneous phage induction, constitutes an important source of eDNA for the S. pneumoniae biofilm matrix and that this localized release of eDNA favors biofilm formation by the remaining bacterial population.
Compositional Changes of Douglas Fir Seeds During Germination (1966)

Changes in weight, water content, nucleic acids, nucleotides, carbohydrates, lipids, nitrogenous and phosphorus compounds in embryo and gametophyte of Douglas fir seeds (Pseudotsuga menziesii Franco) were studied at 6 stages of germination. Lipids, proteins, and reserve phosphorus compounds in the gametophyte were utilized for the synthesis of carbohydrates, structural components, and soluble compounds in the seedling.The general quantitative metabolic changes that occur during germination of Douglas fir seeds are comparable to those known for angiosperm seeds.
A capacity allocation rule for ATM networks (2002)

One of the key issues is how an ATM network estimates the amount of capacity required for supporting a particular application. In this paper, we consider an ATM network as a flexible multi-rate "circuit switched" network with ATM transport, and identify each application (i.e., traffic source) by a metric, namely its equivalent capacity. The objective of this paper is to determine a rule for estimating the equivalent capacity of the application from its traffic descriptor. We model the cell stream of an application its a point process source, and use the Shannon noiseless coding theorem and entropy rate of point processes to derive its equivalent capacity. The resulting rule shows that the equivalent capacity of an application only depends on its peak rate and mean rate. Furthermore, the rule indicates that (i) the equivalent capacity of an application is linearly dependent on the logarithm of its burstiness, and (ii) it is more efficient to multiplex different streams of a multimedia application at higher layers. We also analyze the performance of a network node that operates according to the capacity allocation rule and supports a number of identical bursty applications to obtain its cell loss ratio. The numerical results with bursty data applications indicate that the node satisfies the QOS requirements of stringent bursty applications, and the rule provides a relatively conservative estimate of the required capacity of an application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Analgesic effect of i.v. paracetamol: possible ceiling effect of paracetamol in postoperative pain (2003)

We showed a significant opioid-sparing effect of paracetamol in the immediate postoperative period. Pharmacokinetic data were in accordance with other studies. Our results suggest that a ceiling effect of paracetamol may be present at i.v. doses of 5 mg kg(-1), i.e. a serum concentration of 14 mg l(-1), which is a lower dose than previously suggested.
Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene: II. The Complete Nucleotide Sequences of 400 Mouse KIAA-homologous cDNAs Identified by Screening of Terminal Sequences of cDNA Clones Randomly Sampled from Size-fractionated Libraries (2003)

We have been conducting a mouse cDNA project to predict protein-coding sequences of mouse KIAA-homologous genes since 2001. As an extension of this project, we also started to accumulate mouse cDNA clones homologous to the human FLJ cDNA clones which are another long cDNA resource produced in our institute. We have isolated the cDNA clones from size-fractionated cDNA libraries derived from five different mouse tissues and natural killer T-cells. Although the human FLJ cDNA clones were originally derived from human spleen libraries, one-third of their mouse homologues were obtained from the brain library. We designated these homologues "mFLJ" plus a 5-digit number and herein characterized 110 mFLJ cDNA clones. We assigned an integrity of the CDSs from the comparison of the 110 cDNA clones with the corresponding human FLJ cDNA clones. The average size of the 110 mouse cDNA sequences was 3.8 kb and that of the deduced amino acid sequences from their longest CDS in each cDNA was 663 amino acid residues. Homology and/or motif search against public databases revealed new domains and/or motifs in 26 mFLJ gene products which provide additional speculation regarding the function of FLJ genes.
Properties of Zein Films Coated with Drying Oils (2005)

Zein films prepared by resin were coated with either flax oil or tung oil and cured by UV- or gamma-radiation. Coated zein films were then evaluated for tensile and water barrier properties. Film microstructure was examined by transmitted light microscope. Tensile strength, elongation, and toughness of oil-coated samples increased substantially with respect to uncoated films. Flax oil coated samples showed an increase in elongation of 300%. It was suggested that oil coatings fill in pinholes and cracks existing in zein films, affecting their mechanical properties. Water vapor permeability also decreased statistically for coated film (except for tung oil coated-UV treated films), suggesting water vapor transfer was controlled by film hydrophobicity and microstructure. Moreover, the liquid water transmission rate of coated films was at least 10 times slower than for control films. Examination of film microstructure revealed that flax oil coatings had uniform coverage and smooth finish, which explained their high elongation, low water vapor permeability. Tung oil coatings cured under UV light showed patterns of intertwined dark and light regions, which may be caused by cross-linking and drying at different times. The oriented structures were found when tung oil coatings were cured by gamma-radiation.
Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis (2015)

Tuberculosis (TB) is a global pandaemic, partially due to the failure of vaccination approaches. Novel anti-TB vaccines are therefore urgently required. Here we show that aerosol immunization of macaques with the Mtb mutant in SigH (MtbΔsigH) results in significant recruitment of inducible bronchus-associated lymphoid tissue (iBALT) as well as CD4(+) and CD8(+) T cells expressing activation and proliferation markers to the lungs. Further, the findings indicate that pulmonary vaccination with MtbΔsigH elicited strong central memory CD4(+) and CD8(+) T-cell responses in the lung. Vaccination with MtbΔsigH results in significant protection against a lethal TB challenge, as evidenced by an approximately three log reduction in bacterial burdens, significantly diminished clinical manifestations and granulomatous pathology and characterized by the presence of profound iBALT. This highly protective response is virtually absent in unvaccinated and BCG-vaccinated animals after challenge. These results suggest that future TB vaccine candidates can be developed on the basis of MtbΔsigH.
Scanning system for an echelle monochromator (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTScanning system for an echelle monochromatorDonald L. Anderson, Alan R. Forster, and M. L. ParsonsCite this: Anal. Chem. 1981, 53, 6, 770–775Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ac00229a006https://doi.org/10.1021/ac00229a006research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DIAT: A Scalable Distributed Architecture for IoT (2014)

The advent of Internet of Things (IoT) has boosted the growth in number of devices around us and kindled the possibility of umpteen number of applications. One of the major challenges in the realization of IoT applications is interoperability among various IoT devices and deployments. Thus, the need for a new architecture-comprising smart control and actuation-has been identified by many researchers. In this paper, we propose a Distributed Internet-like Architecture for Things (DIAT), which will overcome most of the obstacles in the process of large-scale expansion of IoT. It specifically addresses heterogeneity of IoT devices, and enables seamless addition of new devices across applications. In addition, we propose an usage control policy model to support security and privacy in a distributed environment. We propose a layered architecture that provides various levels of abstraction to tackle the issues such as scalability, heterogeneity, security, and interoperability. The proposed architecture is coupled with cognitive capabilities that helps in intelligent decision-making and enables automated service creation. Using a comprehensive use-case, comprising elements from multiple-application domains, we illustrate the usability of the proposed architecture.