gebhart/patrepeval huggingface dataset:
Ly-49s3 Is a Promiscuous Activating Rat NK Cell Receptor for Nonclassical MHC Class I-Encoded Target Ligands (2002)

Previous studies of the rapid rejection of MHC-disparate lymphocytes in rats, named allogeneic lymphocyte cytotoxicity, have indicated that rat NK cells express activating receptors for nonclassical MHC class I allodeterminants from the RT1-C/E/M region. Using an expression cloning system that identifies activating receptors associated with the transmembrane adapter molecule DAP12, we have cloned a novel rat Ly-49 receptor that we have termed Ly-49 stimulatory receptor 3 (Ly-49s3). A newly generated anti-Ly-49s3 Ab, mAb DAR13, identified subpopulations of resting and IL-2-activated NK cells, but not T or B lymphocytes. Depletion of Ly-49s3-expressing NK cells drastically reduced alloreactivity in vitro, indicating that this subpopulation is responsible for a major part of the observed NK alloreactivity. DAR13-mediated blockade of Ly-49s3 inhibited killing of MHC-congenic target cells from the av1, n, lv1, and c haplotypes, but not from the u or b haplotypes. A putative ligand was mapped to the nonclassical MHC class I region (RT1-C/E/M) using intra-MHC recombinant strains. Relative numbers of Ly-49s3(+) NK cells were reduced, and surface levels of Ly-49s3 were lower, in MHC congenic strains expressing the putative Ly-49s3 ligand(s). In conclusion, we have identified a novel Ly-49 receptor that triggers rat NK cell-mediated responses.
Telemeterized in vivo hip joint force data: A report on two patients after total hip surgery (1991)

Abstract Two telemeterized femoral components were implanted in two patients as part of normal total hip replacement procedures. The two components were instrumented to measure the three force components directed along: (a) the neck axis, (b) transverse to the neck axis and in the plane of the prosthesis, and (c) transverse to the neck axis and perpendicular to the plane of the prosthesis. Data were collected at multiple sessions during the early postoperative period for a number of standard activities, including gait, stair climbing, rising from a chair, single leg stance, double leg stance, ipsilateral and contralateral straight leg lifts while supine, ipsilateral flexion and extension while standing, and ipsilateral abduction while standing and lying on the contralateral side. These data are summarized and compared with the published results from analytic studies and with the results from previous studies using instrumented femoral components. Peak loads for gait during the period of study were roughly 2.7 body weights (BW) when the patients walked at their normal pace. Contact forces at the hip during stationary single leg stance approximated the peak loads during gait with values ranging from 2.1 to 2.8 BW. The highest forces recorded reached values approaching 5.5 BW and occurred during periods of instability while the patient engaged in stationary single leg stance. Our in vivo data indicate that forces generated during the above activities increase in magnitude quite rapidly during the early postoperative period and that during this period the patients have the ability to perform the activities of daily living without generating the high amplitude joint contact forces suggested by the results of dynamic studies. Joint contact forces during gait were found to depend on speed, but the high absolute magnitudes predicted by model studies were not supported by the in vivo data.
<i>LGI1</i>mutations in temporal lobe epilepsies (2004)

In TLE, mutations in LGI1 are specific for ADPEAF but do not occur in all families. ADPEAF is genetically heterogeneous, but mutations in LGI2, LGI3, or LGI4 did not account for families without LGI1 mutations.
Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes (1991)

Programmed cell death is an essential cellular process that occurs in epithelial turnover, neural development, and regulation of cell populations of the immune system. Thymocytes undergo programmed cell death in response to several inductive stimuli, including exposure to glucocorticoids or radiation. This program can be blocked by inhibitors of RNA or protein synthesis; this implies that new proteins are required to execute the death programs. To search for possible death-associated mRNAs, we directionally cloned cDNA representing mRNA from control and dexamethasone-treated thymocytes. These libraries were used to produce ample amounts of DNA and RNA used in subtractive hybridization for the removal of sequences present in both control and induced cells. The remaining unhybridized sequences were selectively amplified by polymerase chain reaction and cloned to produce a library enriched for sequences expressed in death-induced cells. From this library we isolated cDNAs of death-associated mRNAs. One of these mRNAs, RP-8, appears within 1 h after exposure to gamma radiation, and a second mRNA, RP-2, is observed within 2 h. Both of these mRNAs accumulate during a period when a reference mRNA, actin, is declining. RP-2 and RP-8 are no longer detectable after 6 h postinduction, when apoptosis and mRNA degradation are evident in the culture. Sequence analysis of RP-8 cDNA indicates the presence of a zinc finger domain suggestive of a possible DNA regulatory role for the RP-8 protein. cDNA sequence results on RP-2 classify the corresponding protein as an integral membrane protein. We conclude that RP-2 and RP-8 are death-associated mRNAs that should be functionally evaluated in the context of the death process. As previously suggested, it may be that a family of "death genes" is activated by various stimuli depending on the type of cell, in a manner somewhat analogous to the induction of heat shock (stress) protein genes.
Relationship between space-vector modulation and three-phase carrier-based PWM: a comprehensive analysis [three-phase inverters] (2002)

This paper comprehensively analyzes the relationship between space-vector modulation and three-phase carrier-based pulse width modulation (PWM). The relationships involved, such as the relationship between modulation signals (including zero-sequence component and fundamental components) and space vectors, the relationship between the modulation signals and the space-vector sectors, the relationship between the switching pattern of space-vector modulation and the type of carrier, and the relationship between the distribution of zero vectors and different zero-sequence signal are systematically established. All the relationships provide a bidirectional bridge for the transformation between carrier-based PWM modulators and space-vector modulation modulators. It is shown that all the drawn conclusions are independent of the load type. Furthermore, the implementations of both space-vector modulation and carrier-based PWM in a closed-loop feedback converter are discussed.
Examine Climate Models By Using Infrared Spectrum (2008)

We examine global climate models by comparing the satellite-observed high resolution global infrared spectra with the model-simulated counterpart. Because the topof-the-atmosphere outgoing Earth thermal emission at different frequencies is sensitive to different geophysical variables (temperature, water vapor and other greenhouse gas concentrations, clouds, etc.) at various levels, a comparison of observed and simulated spectra is as challenging as examining a variety of model-simulated geophysical variables simultaneously. Thus, the ability of climate models to replicate the observed spectra provides a strict metric for model validation. This approach adopts a forward radiative transfer calculation and thus avoids the uncertainties associated with retrieving geophysical variables from the radiance measurement. After ensuring consistency in the sampling of the observed and simulated spectra and a proper representation of cloud vertical distribution, the infrared spectra simulated from a state-of-the-art Geophysical Fluid Dynamics Lab climate model are shown to yield a good agreement with those measured by the Atmospheric Infrared Sounder onboard Aqua satellite, in terms of global and regional means. The radiance discrepancies in the water vapor and carbon dioxide _2 bands are consistent with the model biases in atmospheric water vapor and temperature. Furthermore, an examination of the seasonal covariations of the infrared spectra and surface temperatures demonstrates the need and a method to use spectrally resolved radiance to understand and constrain model sensitivity. This study shows that infrared spectrum forms an advantageous means for climate model validation. The study also provides an example of the climatic applications using spectroscopic observations and the molecular absorption database.
Further characteristics important in the operation of ceramic BeO TLD. (1977)

There is now a considerable volume of published research dealing with ceramic BeO--TLD (Crase and Gammage, 1975; Yamashita et al., 1974; Scarpa et al., 1971). Its high sensitivity to radiation (1 mR), cheapness, commercial availability, non-toxicity, chemical stability, an atomic number of near tissue equivalence, and resistance to thermal fading, suggest that it should, by now, have found widespread acceptance as a TLD phosphor. It has not. There are only a small handful of reports dealing with the practical application of this type of dosimeter (Puite et al., 1974; Gammage and Haywood, 1976; Gesell et al., 1975). It seems wise, therefore, to look at the phosphor more closely and to focus on characteristics likely to cause problems under real operating conditions, especially those which are acting as a deterrent to its widespread acceptance. Operational characteristics were studied and the results are discussed.
Motor variability but functional specificity: Demise of the concept of motor commands (1986)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Antibodies to Viral Antigens in Systemic Lupus Erythematosus (1971)

Abstract Sera from 31 patients with lupus erythematosus, 31 controls matched by age and sex and 33 patients with connective tissue disorders other than SLE were examined for specific antibodies to 15 viral antigens by hemagglutination‐inhibition tests. Complement‐fixation tests were also employed to measure antibodies to measles virus and rubella virus. Sera from patients with LE had significantly higher geometric mean antibody titers than matched controls to measles, rubella, parainfluenza types 2 and 3 and reovirus type 2 antigens. When antibody levels from patients with LE were compared with those from patients with other connective tissue disorders, significant differences were noted for measles, rubella, parainfluenza types 1 and 2 and mumps antigens. Removal of nonspecific antinuclear antibodies from selected SLE sera by adsorption with mouse liver nuclear antigens failed to appreciably alter specific viral antibody. The elevated antibody levels in sera from patients with SLE are consistent with the existence of a hyperreactive immunologic state in this disorder and do not necessarily carry etiologic implications.
Paleoethnobotanical Evidence for Deforestation in Ancient Iran: A Case Study of Urban Malyan (1985)

Plant remains from archaeological sites can provide information about the ancient environment. However, these remains should be considered archaeological artifacts, "filtered" through human culture. Adequate interpretation is only possible, and is indeed enriched, by taking the cultural practices of human populations into account. This approach is applied to archaeobotanical materials from Malyan, a fourth to second millennium B.C. site in Fars province, Iran, where there is archaeological evidence for population increase, growing complexity of settlement organization, and technological changes. Clearance of the ancient woodland in the vicinity of Maly an, and concomitant changes in the choice of fuel woods, can account for the observed changes in the proportions of woody taxa found during excavation. In particular, it appears that as the local poplar and juniper were removed, wood of the more distant oak forest was used. Deforestation was a result of a growing population's fuel demands for domestic and technological-especially metallurgical-purposes.
Nanostructured carbon-based electrodes: bridging the gap between thin-film lithium-ion batteries and electrochemical capacitors (2011)

The fast evolution of portable electronic devices and micro-electro-mechanical systems (MEMS) requires multi-functional microscale energy sources that have high power, high energy, long cycle life, and the adaptability to various substrates. Nanostructured thin-film lithium-ion batteries and electrochemical capacitors (ECs) are among the most promising energy storage devices that can meet these demands. This perspective presents an overview of recent progresses and challenges associated with the development of binder-free, carbon-based nanostructured electrodes prepared from layer-by-layer (LbL) electrostatic assembly, which provide enhanced gravimetric and volumetric energy for ECs and enhanced power capabilities for batteries. Based on promising findings for thin electrodes of several microns in thickness, LbL-based electrodes could also potentially be envisioned for portable electronics, electrified transportation, and load-leveling applications if successful scale-up to tens or hundreds of microns can be achieved.
El coronavirus, la auditoría y los cierres contables Texto (2020)

La crisis del coronavirus se este produciendo en un momento en el que las empresas estan formulando sus cuentas anuales y muchos equipos de auditoria estan trabajando para dejar las cifras verificadas. Este articulo ofrece una serie de consideraciones practicas en relacion con el trabajo de los auditores extraidas de la guia «Coronavirus (COVID-19): Considerations for Group Auditors» que pueden resultar de gran utilidad.
The characterization of bacteria with Fourier Transform Infrared(FTIR) Spectroscopy (2005)

New and rapid techniques for the characterization and identification of bacteria would have an important role in clinical microbiology and in food analysis because of an increasing prevalence of infectious diseases and In this work we carried out two approaches. In the first study the characterization and differentiation of mesophilic and thermophilic bacteria were investigated by using Fourier Transform Infrared (FTIR) Spectroscopic technique. In the second study, we investigated the characterization and identification of 3 Bacillus and Micrococcus species Our results from first approach show that there was a dramatic difference between mesophilic and thermophilic bacteria. The protein concentration was high, lipid concentration, the level of triglycerides and the unsaturated acyl chains decreased in thermophilic bacteria. We found that in thermophilic bacteria PO- 2 groups become hydrogen bounded. In addition, our results suggest that the cellular DNA content was low in thermophilic bacteria. Moreover there were characteristic peaks for both mesophilic and thermophilic bacteria and these peaks can be used for the differentiation of these two bacteria group. There were also some specific peaks that can be used for the differentiation of Escherichia coli and Lactobacillus plantarum at species level. In the second approach, our results show that there were significant spectral differences between Bacillus and Micrococcus species such as the proportion of unsaturated acyl chains in triglycerides were higher in Micrococcus species. Moreover we observed different bands that may be explained by an acetate oxidation via the tricarboxylic acid cycle and an exopolymer formation in Micrococcus species. In addition to that another band similar to glycogen, may be explained by a glycogen-like storage material in Micrococcus species. Also there are characteristic peaks that can be used for identification of Micrococcus spp.
Diagnostic Tool for Assessing Overactive Bladder Symptoms: Could the International Prostate Symptom Storage Subscore Replace the Overactive Bladder Symptom Score? (2016)

The results of this cross-sectional analysis suggest that the IPSS-s and the OABSS are not significantly correlated. Although both scores are used to measure OAB symptoms, the simultaneous use of IPSS-s and OABSS is not warranted.
Nucleotide sequence of rat adipose hormone sensitive lipase cDNA (1988)

Journal Article Nucleotide sequence of rat adipose hormone sensitive lipase cDNA Get access Cecilia Holm, Cecilia Holm Search for other works by this author on: Oxford Academic PubMed Google Scholar Todd G. Kirchgessner, Todd G. Kirchgessner 1Departments of Medicine and Microbiology, University of CaliforniaLos Angeles, CA 90024 Search for other works by this author on: Oxford Academic PubMed Google Scholar Karen L. Svenson, Karen L. Svenson 1Departments of Medicine and Microbiology, University of CaliforniaLos Angeles, CA 90024 Search for other works by this author on: Oxford Academic PubMed Google Scholar Aldons J. Lusis, Aldons J. Lusis 1Departments of Medicine and Microbiology, University of CaliforniaLos Angeles, CA 90024 Search for other works by this author on: Oxford Academic PubMed Google Scholar Per Belfrage, Per Belfrage Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael C. Schotz Michael C. Schotz 1Departments of Medicine and Microbiology, University of CaliforniaLos Angeles, CA 900242Research, Veterans Administration, Wadsworth Medical CenterLos Angeles, CA 90073, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 20, 25 October 1988, Page 9879, https://doi.org/10.1093/nar/16.20.9879 Published: 25 October 1988 Article history Received: 02 August 1988 Published: 25 October 1988
Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in<i>cis</i> (2009)

Canonical chromosomal translocations juxtaposing antigen receptor genes and oncogenes are a hallmark of many lymphoid malignancies. These translocations frequently form through the joining of DNA ends from double-strand breaks (DSBs) generated by the recombinase activating gene (RAG)-1 and -2 proteins at lymphocyte antigen receptor loci and breakpoint targets near oncogenes. Our understanding of chromosomal breakpoint target selection comes primarily from the analyses of these lesions, which are selected based on their transforming properties. RAG DSBs are rarely resolved aberrantly in wild-type developing lymphocytes. However, in ataxia telangiectasia mutated (ATM)-deficient lymphocytes, RAG breaks are frequently joined aberrantly, forming chromosomal lesions such as translocations that predispose (ATM)-deficient mice and humans to the development of lymphoid malignancies. Here, an approach that minimizes selection biases is used to isolate a large cohort of breakpoint targets of aberrantly resolved RAG DSBs in Atm-deficient lymphocytes. Analyses of this cohort revealed that frequently, the breakpoint targets for aberrantly resolved RAG breaks are other DSBs. Moreover, these nonselected lesions exhibit a bias for using breakpoints in cis, forming small chromosomal deletions, rather than breakpoints in trans, forming chromosomal translocations.
The surface chemistry of proteins (1950)

C. W. N. Cumper and A. E. Alexander, Trans. Faraday Soc., 1950, 46, 235 DOI: 10.1039/TF9504600235
Direct form I fiber-optic discrete-time signal processors using optical amplifiers and embedded Mach-Zehnder structures (1993)

The use of optical amplifiers and the optical-fiber embedded Mach-Zehnder architecture to implement reconfigurable discrete-time optical signal processors with direct form I structures is considered. Passive optical fibers and waveguides are used as signal delay lines. 2*2 directional couplers in an embedded Mach-Zehnder layout are used as signal adders and tapping elements. Active fibers (waveguides) are used as signal multipliers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dettes des ménages et fragilité financière (1991)

Cet de faillites recents article nombreux personnelles developpements cherche traits a determiner dans communs de les pays l'endettement les a developpes. tous causes ces et des les pays On consequences menages : peut le declin distinguer et des des des recents developpements de l'endettement des menages et des faillites personnelles dans les pays developpes. On peut distinguer de no breux traits communs a t us ces pays : le declin de restrictions de credit, l'augmentation du niveau de l'endettement par rapport aux revenus, et (dans une moindre mesure) des ratios endettement/capital. L'augmentation que l'on observe tout particulierement (mais pas exclusivement) pendant les recessions, du nombre de faillites personnelles, et la baisse des taux d'epargne. On peut penser que ces particularites peuvent etre en partie liees a la liberalisation financiere. L'article est structure de la facon suivante : dans la section I, on presentera les principaux chiffres concernant l'endettement des menages ; dans la section II seront ebauchees deux approches theoriques complementaires, concernant respectivement la demande de credit des menages, et les comportements de pret des intermediaires financiers. Ces elements fourniront la base d'analyse de la section III, ou premierement, on esquissera une interpretation theorique des tendances recentes, et ou, deuxiemement, on presentera une analyse econometrique du lien existant entre l'endettement et les faillites personnelles.
Foundations of discrete mathematics (1990)

From the Publisher:
Introduces the process of abstraction, studies two elementary structures on sets, and covers the necessary generalities concerning algebraic structures. Presents powerful abstract mathematical concepts from algebra and combinatorics, supported by concrete applications. All background material is provided, including elements of logic, set theory, abstract algebra, linear algebra, and graph theory. Each chapter develops a new mathematical concept, then shows how to apply it. Includes numerous end-of-chapter problems and exercises.
Engineering alcohol tolerance in yeast (2014)

Ethanol toxicity in the yeast Saccharomyces cerevisiae limits titer and productivity in the industrial production of transportation bioethanol. We show that strengthening the opposing potassium and proton electrochemical membrane gradients is a mechanism that enhances general resistance to multiple alcohols. The elevation of extracellular potassium and pH physically bolsters these gradients, increasing tolerance to higher alcohols and ethanol fermentation in commercial and laboratory strains (including a xylose-fermenting strain) under industrial-like conditions. Production per cell remains largely unchanged, with improvements deriving from heightened population viability. Likewise, up-regulation of the potassium and proton pumps in the laboratory strain enhances performance to levels exceeding those of industrial strains. Although genetically complex, alcohol tolerance can thus be dominated by a single cellular process, one controlled by a major physicochemical component but amenable to biological augmentation.