gebhart/patrepeval huggingface dataset:
Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor (2008)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTAllosteric Modulators of the α7 Nicotinic Acetylcholine ReceptorRamin Faghih*, Murali Gopalakrishnan, and Clark A. BriggsView Author Information Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064* To whom correspondence should be addressed. Phone: 847-937-2972 . Fax: 847-937-4143. E-mail: [email protected]aAbbreviations: nAChR, nicotinic acetylcholine receptor; ACh, acetylcholine; PAM, positive allosteric modulator; NAM, negative allosteric modulator; VGIC, voltage-gated ion channels; LGIC, ligand-gated ion channels; TM, transmembrane; GPCR, G-protein-coupled receptors; CNS, central nervous system; PNS, peripheral nervous system; MLA, methyllycaconitine; MCI, mild cognitive impairment; AD, Alzheimer's disease; TNF-α, tumor necrosis factor; CSF, cerebrospinal fluid; NMDA, N-methyl-d-aspartate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GABAA, γ-aminobutyric acid; 5-HT3, 5-hydroxytryptamine-3.Cite this: J. Med. Chem. 2008, 51, 4, 701–712Publication Date (Web):January 17, 2008Publication History Received7 March 2007Published online17 January 2008Published inissue 1 February 2008https://pubs.acs.org/doi/10.1021/jm070256ghttps://doi.org/10.1021/jm070256greview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views2438Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Ligands,Modulators,Polyacrylamide,Receptors Get e-Alerts
The DESDynI synthetic aperture radar array-fed reflector antenna (2010)

DESDynI is a mission being developed by NASA with radar and lidar instruments for Earth-orbit remote sensing. This paper focuses on the design of a large-aperture antenna for the radar instrument. The antenna comprises a deployable reflector antenna and an active switched array of patch elements fed by transmit / receive modules. The antenna and radar architecture facilitates a new mode of synthetic aperture radar imaging called `SweepSAR'. A system-level description of the antenna is provided, along with predictions of antenna performance.
Knitting (1930)

Knitting Get access O. L. O. L. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 158, Issue 20, 17 May 1930, Page 359, https://doi.org/10.1093/nq/158.20.359a Published: 17 May 1930
ChemInform Abstract: THIENOPYRIDINES. PART 4. PREPARATION OF SOME DITHIENO(3,2‐B:2′,3′‐D)PYRIDINE DERIVATIVES (1982)

Abstract Das Dithienopyridin (V) ist aus dem Thienopyridon (I) über die Stufen (II) und (IV) oder auch über (III) und (VI) erhältlich.
Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux (2004)

To date, most concepts on the frequency of gastro-oesophageal reflux episodes and the efficiency of the antireflux barrier have been based on inferences derived from measurement of oesophageal pH. The development of intraluminal impedance monitoring has highlighted the fact that pH monitoring does not detect all gastro-oesophageal reflux events when little or no acid is present in the refluxate, even if special pH tracing analysis criteria are used. In November 2002, a workshop took place at which 11 specialists in the field of gastro-oesophageal reflux disease discussed and criticised all currently available techniques for measurement of reflux. Here, a summary of their conclusions and recommendations of how to achieve the best results from the various techniques now available for reflux measurement is presented.
VILLISMO Y ZAPATISMO: LA REVOLUCION DE LOS VENCIDOS (1980)

EN HISTORIOGRAFIA OFICIALISTA; REVOLUCION MEXICANA HA SIDO MANEJADA CON CIERTO MANIQUEISMO; PUES SE LE PRESENTA COMO UNA LUCHA ABIERTA ENTRE BUENOS Y MALOS; AFIRMO LICENCIADA GUADALUPE VILLA; INVESTIGADORA DEL INSTITUTO NACIONAL DE ANTROPOLOGIA E HISTORIA; DURANTE CONFERENCIA LA REVOLUCION MEXICANA: NARRATIVA DIRECTA VS HISTORIOGRAFIA OFICIAL; CON QUE INICIO EN DIAS PASADOS EL CICLO VISION POPULAR DE REVOLUCION MEXICANA; EN LIBRERIA UNIVERSITARIA DE INSURGENTES.
Viremia Copy-Years Predicts Mortality Among Treatment-Naive HIV-Infected Patients Initiating Antiretroviral Therapy (2011)

Viremia copy-years predicted all-cause mortality independent of traditional, cross-sectional VL measures and time-updated CD4+ T-lymphocyte count in ART-treated patients, suggesting cumulative HIV replication causes harm independent of its effect on the degree of immunodeficiency.
The Franz–Keldysh effect in shocked GaN:Mg (2003)

The band gap of uniaxially strained semi-insulating GaN:Mg has been examined using time-resolved optical transmission measurements in shock-wave experiments. For longitudinal stresses between 2.9 and 4.6 GPa, the absorption edge broadened significantly. Such a broadening is consistent with the presence of large piezoelectric fields (Franz–Keldysh effect) generated due to shock compression. For stresses greater than 4.6 GPa, however, the absorption edge remained relatively sharp. The sharp absorption onset suggests the presence of free charge carriers that screen the piezoelectric field, thereby suppressing the Franz–Keldysh effect. These observations indicate that electrical breakdown occurs at a field of 1 MV/cm. One possible mechanism that could result in free carriers is the dissociation of Mg–H complexes under the very high piezoelectric fields.
Genetic Complexity and Quantitative Trait Loci Mapping of Yeast Morphological Traits (2007)

Functional genomics relies on two essential parameters: the sensitivity of phenotypic measures and the power to detect genomic perturbations that cause phenotypic variations. In model organisms, two types of perturbations are widely used. Artificial mutations can be introduced in virtually any gene and allow the systematic analysis of gene function via mutants fitness. Alternatively, natural genetic variations can be associated to particular phenotypes via genetic mapping. However, the access to genome manipulation and breeding provided by model organisms is sometimes counterbalanced by phenotyping limitations. Here we investigated the natural genetic diversity of Saccharomyces cerevisiae cellular morphology using a very sensitive high-throughput imaging platform. We quantified 501 morphological parameters in over 50,000 yeast cells from a cross between two wild-type divergent backgrounds. Extensive morphological differences were found between these backgrounds. The genetic architecture of the traits was complex, with evidence of both epistasis and transgressive segregation. We mapped quantitative trait loci (QTL) for 67 traits and discovered 364 correlations between traits segregation and inheritance of gene expression levels. We validated one QTL by the replacement of a single base in the genome. This study illustrates the natural diversity and complexity of cellular traits among natural yeast strains and provides an ideal framework for a genetical genomics dissection of multiple traits. Our results did not overlap with results previously obtained from systematic deletion strains, showing that both approaches are necessary for the functional exploration of genomes.
THE EFFECT OF WIND ON THE THERMAL RESISTANCE OF CLOTHING WITH SPECIAL REFERENCE TO THE PROTECTION GIVEN BY COVERALL FABRICS OF VARIOUS PERMEABILITIES (1947)

The thermal resistance of a pile fabric uncovered and covered with thin fabrics of various permeabilities was measured under different conditions of wind velocities and wind direction. Wind velocities up to 30 m.p.h. were used and tests were carried out with winds striking the surface of the material at 0°, 30°, 45°, and 90°. The permeabilities of the covers varied between 0 and 193 cu. ft. per sq. ft. per min., under a pressure difference of [Formula: see text] in. of water across the fabric. The effects of varying the conditions of the thermal resistance of the boundary air layer are discussed and corrections applied to the results for the resistance of this air layer. The results show that for low wind velocities, the permeability, within wide limits, is relatively of little importance, but with higher wind velocities it is advantageous to employ a covering fabric of as low a permeability as possible.
Ultraviolet radiation directly induces pigment production by cultured human melanocytes (1987)

In humans the major stimulus for cutaneous pigmentation is ultraviolet radiation (UVR). Little is known about the mechanism underlying this response, in part because of the complexity of interactions in whole epidermis. Using a recently developed culture system, human melanocytes were exposed daily to a physiologic range of UVR doses from a solar simulator. Responses were determined 24 hours after the last exposure. There was a dose-related increase in melanin content per cell and uptake of 14C-DOPA, accompanied by growth inhibition. Cells from donors of different racial origin gave proportionately similar increases in melanin, although there were approximately tenfold differences in basal values. Light and electron microscopy revealed UVR-stimulated increases in dendricity as well as melanosome number and degree of melanization, analogous to the well-recognized melanocyte changes following sun exposure of intact skin. Similar responses were seen with Cloudman S91 melanoma cells, although this murine cell line required lower UVR dosages and fewer exposures for maximal stimulation. These data establish that UVR is capable of directly stimulating melanogenesis. Because cyclic AMP elevation has been associated in some settings with increased pigment production by cultured melanocytes, preliminary experiments were conducted to see if the effects of UVR were mediated by cAMP. Both alpha-MSH and isobutylmethylxanthine (IBMX), as positive controls, caused a fourfold increase in cAMP level in human melanocytes and/or S91 cells, but following a dose of UVR sufficient to stimulate pigment production there was no change in cAMP level up to 4 hours after exposure. Thus it appears that the UVR-induced melanogenesis is mediated by cAMP-independent mechanisms.
Effects of soil and climate input data aggregation on modelling regional crop yields (2015)

Climate and soil data at coarse resolution are often used as input for crop models in order to simulate crop yields at larger scales, e.g. at regional or national level, potentially leading to biased yield estimates. While the response to data resolution differs between crop models, it is unknown how the spatial aggregation of different types of input data interacts and contributes to this so-called aggregation effect.  An ensemble of crop models was run with soil and climate input data at different spatial resolutions from 1 to 100 km for the state of North Rhine-Westphalia, Germany. For this purpose, climate time series were averaged spatially and soil data was aggregated by selecting the dominant soil type with a representative soil profile based on a soil map at the scale of 1:50,000. Yields of winter wheat and silage maize were simulated under potential, water-limited and water-nitrogen-limited production conditions. Crop yields from soil and climate aggregation were evaluated separately. Mean of crop yields of the region and over the simulation period were reasonably reproduced by most models regardless of input data resolution, either using aggregated soil or climate as input. However, larger aggregation effects were observed at higher temporal resolution (e.g. annual yields). Models revealed similar spatial patterns in yield. Being distinct for soil and climate aggregation, these patterns indicate a larger impact of soil aggregation on the spatial distribution of simulated crop yield for this region. Additionally, models differed considerably in their susceptibility to input data aggregation. The results reveal the importance of model ensemble assessments and the relevance of data aggregation when short simulation periods are considered.
Psychiatric side effects of levodopa in man (1971)

Levodopa is the amino acid precursor of the cathecholamines, dopamine and norepinephrine. Along with serotonin, these catecholamines serve as neurotransmitters in areas of the brain related to psychomotor, vegetative, and emotional functions; thus, it is not surprising that the administration of levodopa is associated with mental changes. The documentation and quantification of these mental effects is particularly important because of the potential for increasing our basic understanding of the relationship between brain amines (particularly dopamine) and psychological states both normal and abnormal. When administered to animals, levodopa has been shown to produce a variety of behavioral effects depending to some extent on the dose and species employed; in general, high doses of levodopa produce alerting, motor activation and increased aggressiveness. These studies have recently been the subject of extensive reviews.<sup>1,2</sup> The rationale for the use of levodopa in Parkinsonism is based on evidence that a dopamine deficiency exists in
A self-tuning closed-loop flux observer for sensorless torque control of standard induction machines (1997)

This paper proposes a self-tuning closed-loop flux observer, which provides field-oriented torque control for induction machines without a tachometer. The proposed algorithm combines the best features of harmonic detection and stator voltage integration through the use of a new tuning scheme. The observer accuracy and robustness is augmented by a parameter-independent accurate-speed detector, which analyzes magnetic saliency harmonics in the stator current. The harmonic-detection scheme provides accurate rotor-speed updates during steady-state operation down to 1-Hz source frequency. This additional speed information is used to tune the rotor-resistance parameter of the observer. The tuned observer exhibits improved dynamic performance, accurate steady-state speed control and an extended range of control near zero speed. The algorithm requires no special machine modifications and can be implemented on most existing low- and medium-performance drives. The closed-loop nature of the flux observer, combined with the harmonic-detection scheme, provides flux and speed error feedback, which significantly increases the robustness of sensorless control across the entire speed range.
Learning Blind Motion Deblurring (2017)

As handheld video cameras are now commonplace and available in every smartphone, images and videos can be recorded almost everywhere at anytime. However, taking a quick shot frequently yields a blurry result due to unwanted camera shake during recording or moving objects in the scene. Removing these artifacts from the blurry recordings is a highly ill-posed problem as neither the sharp image nor the motion blur kernel is known. Propagating information between multiple consecutive blurry observations can help restore the desired sharp image or video. In this work, we propose an efficient approach to produce a significant amount of realistic training data and introduce a novel recurrent network architecture to deblur frames taking temporal information into account, which can efficiently handle arbitrary spatial and temporal input sizes.
Simultaneous Purification and Site‐Specific Modification of Pyrroline‐Carboxy‐Lysine Proteins (2012)

Sticky residue: Pyrroline-carboxy-lysine (Pcl) can be readily incorporated into proteins expressed in E. coli and mammalian cells by using the pyrrolysyl tRNA/tRNA synthetase pair. Pcl can be used as a single amino acid purification tag and can be site-specifically modified with functional probes during the elution process.
Coherent Intrachain Energy Migration in a Conjugated Polymer at Room Temperature (2009)

The intermediate coupling regime for electronic energy transfer is of particular interest because excitation moves in space, as in a classical hopping mechanism, but quantum phase information is conserved. We conducted an ultrafast polarization experiment specifically designed to observe quantum coherent dynamics in this regime. Conjugated polymer samples with different chain conformations were examined as model multichromophoric systems. The data, recorded at room temperature, reveal coherent intrachain (but not interchain) electronic energy transfer. Our results suggest that quantum transport effects occur at room temperature when chemical donor-acceptor bonds help to correlate dephasing perturbations.
Limited feedback Zero Forcing precoding scheme for MIMO-broadcast channels (2008)

This paper proposes a codebook based limited feedback zero-forcing(ZF) precoding scheme for multi-user multiple-input multiple-output (MIMO) downlink channels. In such system, each user needs to calculate a channel directional index (CDI) and a channel quality indicator (CQI), feedback them to the base station (BS). BS selects the set of active users, and calculates transmit beams through zero forcing method. In case of rank-one feedback, each user should combine the MIMO channel into a multiple-input single-output (MISO) channel through a receiver weight, then feedback CDI and CQI of this combined channel. Current existing schemes use the Hermitian of the left eigenvector associated to the maximum eigenvalue of the channel as the weight. The problem is that when there is multi-user interference, the feedback information is inaccurate. Focusing on this problem, we propose a new feedback scheme which uses a quasi minimum mean squared error (MMSE) weight to calculate CQI and CDI. By the simulations in 3GPP long term evaluation (LTE) environment, the proposed scheme is proved to achieve higher spectrum efficiency than the existing schemes.
A Method for Sharing Traffic Jam Information using Inter-Vehicle Communication (2006)

In this paper, we propose a method for cars to autonomously and cooperatively collect traffic jam statistics to estimate arrival time to destination for each car using inter-vehicle communication. In the method, the target geographical region is divided into areas, and each car measures time to pass through each area. Traffic information is collected by exchanging information between cars using inter-vehicle communication. In order to improve accuracy of estimation, we introduce several mechanisms to avoid same data to be repeatedly counted. Since wireless bandwidth usable for exchanging statistics information is limited, the proposed method includes a mechanism to categorize data, and send important data prior to other data. In order to evaluate effectiveness of the proposed method, we implemented the method on a traffic simulator NETSTREAM developed by Toyota Central R&D Labs, conducted some experiments and confirmed that the method achieves practical performance in sharing traffic jam information using inter-vehicle communication
Molecular analysis of the duchenne muscular dystrophy gene in patients with becker muscular dystrophy presenting with dilated cardiomyopathy (1993)

Molecular analysis of the Duchenne muscular dystrophy (DMD) gene was performed on 4 unrelated patients with Becker muscular dystrophy (BMD) presenting with dilated cardiomyopathy. Two patients with a deletion involving exon 1 were quite unique in that they developed fatal myocardial involvement in their teens, despite the absence of significant muscular weakness. The deletion found in these patients comprised the 3'-end of exon 1 and the greater part of intron 1. Two other patients with a deletion of exon 47 showed progressive muscular atrophy and weakness; they were considered to be typical BMD in both clinical features and the type of gene deletion. We speculate that a deletion around exon 1 may severely damage the expression and/or the function of dystrophin selectively in cardiac muscle, but not in skeletal muscle.
Phase II study of gemcitabine in children with solid tumors of mesenchymal and embryonic origin (2006)

Among the several different combination chemotherapy regimens for the treatment of patients with metastatic colorectal cancer, oxaliplatin plus raltitrexed has shown encouraging therapeutic results and a fairly good toxicity profile. Here, we report on two patients with metastatic colorectal cancer receiving this combination therapy, which leads to severe enterocolitis and neutropenia resulting in death in one patient. One patient was a 67-year-old woman suffering from an adenocarcinoma of the sigmoid colon with multiple liver metastases. The other patient was a 74-year-old woman with colon cancer, and metachronous multiple pulmonal and hepatic metastases. In both patients, palliative chemotherapy consisted of oxaliplatin 130 mg/m2 in combination with raltitrexed 3 mg/m2 on day 1 every 21 days. Both patients developed neutropenia in combination with severe enterocolitis after the fourth and the second chemotherapy cycle, respectively. Despite antibiotic treatment, diarrhea persisted in both patients for weeks. One patient died 17 days after hospital admission because of enteric sepsis with bleeding of the colonic mucosa and multiorgan failure. The other patient recovered completely and was discharged from hospital after 8 weeks. Severe enterocolitis, a hitherto infrequently recognized adverse event, which has been described in association with 5-fluorouracil/leucovorin and oxaliplatin chemotherapy, may also occur with raltitrexed and oxaliplatin. Physicians should be aware of this rare, although potentially lethal, gastrointestinal toxicity.
Recent advances in multicomponent processing (1999)

The evolution of 3-D multicomponent processing and collection methods has increased our information about reservoirs. Processing techniques now exist to generate a time or depth image of P-to-S converted waves (or C-waves) using ocean-bottom sensors. These images can enhance reservoir characterization, especially when shallow gas clouds may inhibit compressional wave propagation.
Knowledge Management in the Intelligence Enterprise (2003)

From the Publisher:
Knowledge Management in the Intelligence Enterprise is essential reading for professionals who are responsible for the management of an intelligence enterprise operation and its timely and accurate delivery of reliable intelligence to key decision makers. It is the first easy-to-understand, system-level book that specifically applies knowledge management principles, practices, and technologies to the intelligence domain. The book describes the fundamental principles of intelligence, from collection, processing, and analysis, to dissemination for both national intelligence and business applications.