gebhart/patrepeval huggingface dataset:
Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression (2002)

Evidence suggests that T lymphocyte-mediated inhibition of hematopoiesis in myelodysplastic syndrome (MDS) contributes to cytopenia in some patients and can be reversed by treatment with immunosuppression. We examined the T-cell repertoires of 12 patients with MDS before and after antithymocyte globulin (ATG)-based treatment by T-cell receptor Vbeta (TCR-Vbeta) spectratype analysis. The average number of TCR-Vbeta families with skewed spectratypes, representative of clonal or oligoclonal T-cell populations, was 7.6 in MDS patients before treatment and 3.2 in healthy controls (P =.02). Four patients who recovered effective hematopoiesis after treatment lost prominent, skewed peaks on their spectratypes, suggesting loss or diminution of overrepresented clonal T-cell populations. In contrast, patients who did not recover effective hematopoiesis showed persistently skewed repertoires 3 to 6 months after treatment. In 3 patients with skewed repertoires, cDNA from the complementarity-determining region 3 (CDR3) of 4 TCR-Vbeta families was cloned and repetitively sequenced, confirming clonal T-cell dominance in each family. In one nonresponder, 16 of 19 CDR3 sequences were identical, demonstrating that 9.3% of the total T-cell population was made up of a single clone. By 6 months after treatment, this clone persisted on both spectratype and DNA sequence complementarity and when analyzed by flow cytometry was shown to be CD8(+)/CD45RA(+)/HLA-DR(-). T-cell clones were not anergic because they could be expanded 4-fold in vitro. Our results demonstrate that predominant clonal T cells that appear to be antigen-driven persist in patients with MDS unresponsive to immunosuppression, but predominant clones regress in responders to immunosuppression.
A New Technology for Automatic Identification and Sorting of Plastics for Recycling (2004)

A new technology for automatic sorting of plastics, based upon optical identification of fluorescence signatures of dyes, incorporated in such materials in trace concentrations prior to product manufacturing, is described. Three commercial tracers were selected primarily on the basis of their good absorbency in the 310-370 nm spectral band and their identifiable narrow-band fluorescence signatures in the visible band of the spectrum when present in binary combinations. This absorption band was selected because of the availability of strong emission lines in this band from a commercial Hg-arc lamp and high fluorescence quantum yields of the tracers at this excitation wavelength band. The plastics chosen for tracing and identification are HDPE, LDPE, PP, EVA, PVC and PET and the tracers were compatible and chemically non-reactive with the host matrices and did not affect the transparency of the plastics. The design of a monochromatic and collimated excitation source, the sensor system are described and their performances in identifying and sorting plastics doped with tracers at a few parts per million concentration levels are evaluated. In an industrial sorting system, the sensor was able to sort 300 mm long plastic bottles at a conveyor belt speed of 3.5 m.sec(-1) with a sorting purity of -95%. The limitation was imposed due to mechanical singulation irregularities at high speed and the limited processing speed of the computer used.
Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan (2004)

A multicenter case-control study was conducted in northern and southern Taiwan to clarify the independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer. A total of 513 patients with newly diagnosed and histopathologically confirmed squamous cell carcinoma of the esophagus and 818 gender, age and study hospital-matched controls were included. We found a significant dose-response relationship between the duration and intensity of consumption of the 3 substances and the development of this neoplasm in this site. Although the amount of alcohol consumed had a stronger effect on the risk of esophageal cancer than the number of years it was consumed, however, the number of years one smoked had a stronger effect on the risk than the amount of cigarettes consumed. The strongest risk factor of esophageal cancer was alcohol intake, with highest risk (OR = 13.9) being for those who consumed more than 900 g/day-year. Combined exposure to any 2 of 3 substances brought the risks up to 8.8-19.7 fold and, to all 3 substances, to 41.2-fold. A multiplicative interaction effect for alcohol drinkers who smoked on cancer risk was detected, whereas an additive interaction effect was found among drinkers who chewed. The combined effect of all 3 substances accounted for 83.7% of the attributable fraction of contracting esophageal cancer in this population. In conclusion, these results suggest that the intensity and the length of time alcohol and tobacco are used play different roles in the etiology of esophageal cancer. Alcohol separately interacts with tobacco and betel quid in a differently synergistic way in determining the development of this site of cancer.
A 128-Tap Highly Tunable CMOS IF Finite Impulse Response Filter for Pulsed Radar Applications (2018)

A configurable-bandwidth (BW) filter is presented in this paper for pulsed radar applications. To eliminate dispersion effects in the received waveform, a finite impulse response (FIR) topology is proposed, which has a measured standard deviation of an in-band group delay of 11 ns that is primarily dominated by the inherent, fully predictable delay introduced by the sample-and-hold. The filter operates at an IF of 20 MHz, and is tunable in BW from 1.5 to 15 MHz, which makes it optimal to be used with varying pulse widths in the radar. Employing a total of 128 taps, the FIR filter provides greater than 50-dB sharp attenuation in the stopband in order to minimize all out-of-band noise in the low signal-to-noise received radar signal. Fabricated in a 0.18-μm silicon on insulator CMOS process, the proposed filter consumes approximately 3.5 mW/tap with a 1.8-V supply. A 20-MHz two-tone measurement with 200-kHz tone separation shows IIP3 greater than 8.5 dBm.
Ethylene/1‐octene copolymerization studies with <i>in situ</i> supported metallocene catalysts: Effect of polymerization parameters on the catalyst activity and polymer microstructure (2002)

Abstract Ethylene and 1‐octene copolymerizations were carried out with an in situ supported rac ‐[dimethylsilylbis(methylbenzoindenyl)] zirconium dichloride catalyst. In a previous study, it was found that some in situ supported metallocenes produced polyethylene/α‐olefin copolymers with broad and bimodal short chain branching distributions and narrow molecular weight distributions. The ability to produce polyolefins with multimodal microstructural distributions in a single metallocene and a single reactor is attractive for producing polymers with balanced properties with simpler reactor technology. In this study, a factorial experimental design was carried out to examine the effects of the polymerization temperature and ethylene pressure, the presence of hydrogen and an alkylaluminum activator, and the level of the comonomer in the feed on the catalyst activity, short chain branching distribution, and molecular weight distribution of the polymer. The temperature had the most remarkable effect on the polymer microstructure. At high 1‐octene levels, the short chain branching distribution of the copolymer broadened significantly with decreasing temperature. Several factor interactions, including the hydrogen and alkylaluminum concentrations, were also observed, demonstrating the sensitivity of the catalyst to the polymerization conditions. For this catalyst system, the responses to the polymerization conditions are not easily predicted from typical polymerization mechanisms, and several two‐factor interactions seem to play an important role. Given the multiple‐site nature of the catalyst, it has been shown that predicting the polymerization activity and the resulting microstructure of the polymer is a challenging task. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 4426–4451, 2002
Biomechanics of Milking: Teat - Liner Interactions (2009)

This purpose of this paper is to clarify the concept of liner compression and to show the practical importance of understanding and controlling its effects. The degree of compression applied to the teat by the teatcup liner in the d-phase of pulsation has a marked influence on teat condition, cow comfort and peak milk flow-rate. The influence of liner compression on these three characteristics is at least as great as the effects of pulsator ratio, pulsation rate, and the rates of change in air pressure in the teatcup pulsation chamber. Liner Compression (LC) is defined here as the mean compressive pressure which is applied to the inner tissues of the teat apex by the liner during the d-phase of pulsation. Over-pressure (OP) is defined as the mean compressive pressure, above that required to stop milk flowing from the teat, which is applied to the inner tissues of the teat apex by the liner during the d-phase. Thus, OP is a major component of LC. Liner OP values within the range 8-12 kPa appear to achieve the main purposes of pulsation and to maintain good teat condition and cow comfort. OP values < 8 kPa may be too low to fully relieve teat wall congestion induced by the milking vacuum during the b-phase of pulsation. Peak milking rate continues to increase up to liner OP values of 14 kPa. However, the proportion of cows with poorer teat-end condition (hyperkeratosis) appears to be greater at OP values of 14 kPa or more.
New Asymmetric Reactions Using a Gallium Complex:  A Highly Enantioselective Ring Opening of Epoxides with Thiols Catalyzed by a Gallium·Lithium·Bis(binaphthoxide) Complex (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNew Asymmetric Reactions Using a Gallium Complex: A Highly Enantioselective Ring Opening of Epoxides with Thiols Catalyzed by a Gallium·Lithium·Bis(binaphthoxide) ComplexTakehiko Iida, Noriyoshi Yamamoto, Hiroaki Sasai, and Masakatsu ShibasakiView Author Information Faculty of Pharmaceutical Sciences University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, Japan Cite this: J. Am. Chem. Soc. 1997, 119, 20, 4783–4784Publication Date (Web):May 21, 1997Publication History Received27 January 1997Published online21 May 1997Published inissue 1 May 1997https://pubs.acs.org/doi/10.1021/ja9702576https://doi.org/10.1021/ja9702576rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2092Altmetric-Citations201LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Catalysts,Ethers,Lithium,Substitution reactions,Thiols Get e-Alerts
A direct equalization method (2002)

The unshielded twisted pair can be used as a transmission media for local distribution networks. To maintain a high transmission throughput, an analog or a digital adaptive channel equalizer is usually required in the receiver to minimize the effect of inter-symbol interference. Under the observation that the high sampling rate high precision A/D and subsequent digital adaptive signal processing is an expensive approach, a direct equalization method, where the equalizer is implemented in the transmitter, is proposed for symmetrical twisted pair transmission channels. This direct equalization method can also be applied to the analog equalization approach for reduced system complexity.
Differences in Airway Inflammation in Patients with Fixed Airflow Obstruction Due to Asthma or Chronic Obstructive Pulmonary Disease (2003)

To determine whether patients with fixed airflow obstruction have distinct pathologic and functional characteristics depending on a history of either asthma or chronic obstructive pulmonary disease (COPD), we characterized 46 consecutive outpatients presenting with fixed airflow obstruction by clinical history, pulmonary function tests, exhaled nitric oxide, sputum analysis, bronchoalveolar lavage, bronchial biopsy, and high-resolution computed tomography chest scans. Subjects with a history of COPD (n = 27) and subjects with a history of asthma (n = 19) had a similar degree of fixed airflow obstruction (FEV1: 56 +/- 2 versus 56 +/- 3% predicted) and airway hyperresponsiveness (PC20FEV1: 2.81 [3.1] versus 1.17 [3.3]). Subjects with a history of asthma had significantly more eosinophils in peripheral blood, sputum, bronchoalveolar lavage, and airway mucosa; fewer neutrophils in sputum and bronchoalveolar lavage fluid; a higher CD4+/CD8+ ratio of T cells infiltrating the airway mucosa; and a thicker reticular layer of the epithelial basement membrane. They also had significantly lower residual volume, higher diffusing capacity, higher exhaled nitric oxide, lower high-resolution computed tomography scan emphysema score, and greater reversibility to bronchodilator and steroids. In conclusion, despite similar fixed airflow obstruction, subjects with a history of asthma have distinct characteristics compared with subjects with a history of COPD and should be properly identified and treated.
Dynamic Regulation of Oct1 during Mitosis by Phosphorylation and Ubiquitination (2011)

These findings reveal mechanistic coupling between Oct1 phosphorylation and ubquitination during mitotic progression, and a role for Oct1 in mitosis.
Automated interpretation of SEM images (2002)

An important part of quality control in the fabrication of integrated circuit wafers involves making 3D measurements of the wafer's surface topography. We describe a method for obtaining a dense depth map of the of the surface from a single scanning electron microscope (SEM) image. The depth map gives a complete description of the surface topography, allowing the easy calculation of any measurement required in the quality control process. The technique presented uses a novel scale-space shape-from-shading algorithm. Results are shown for real SEM images and for a synthetic test image. We also describe how the method can be extended to use stereo images in order to achieve greater accuracy in the surface reconstruction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Diagnostic Molecular Microbiology: Nucleic Acid Probes and Microbes (2003)

This review describes a case of an HIV-infected individual that conveys important lessons for the use of molecular methods in medical microbiology. The practical roles of viral load testing and genotyping (resistance testing) are discussed in the context of patient diagnosis and management.
J-function based geometric reasoning for robotics. I. A new distance measure for collision detection and grasping (2002)

This paper presents the J-function (Junction) approach to denoting a pseudo distance measure, which can be applied to collision detection, navigation, find space problem and find path problem. Unlike other distance measure, the Junction describes both qualitative and quantative relationships of the spatial locations between two objects A and B. The developed Junction algorithm solves the problems in real world space, configuration space and screw space. At one hand, the Junction's value represents how far is it between the two objects; at the other hand, its solution will give the geometric and topological relationship between them. In the case of A/spl cap/B=/spl Phi/, the solution will indicate the nearest point pair.
The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin. (1992)

We previously described a novel molecular chaperone (designated p88) that participates in the assembly of murine class I histocompatibility molecules (Degen, E., and Williams, D. B. (1991) J. Cell Biol. 112, 1099-1115). Our findings suggest that p88 may either promote proper assembly of class I molecules or retain them, probably within the endoplasmic reticulum (ER), until assembly of the ternary complex of heavy chain, beta 2-microglobulin, and peptide ligand is complete. In this report, we compare p88 to calnexin, a calcium-binding 90-kDa phosphoprotein of the ER membrane (Wada, I., Rindress, D., Cameron, P. H., Ou, W.-J., Doherty, J.-J., II, Louvard, D., Bell, A.W., Dignard, D., Thomas, D. Y., and Bergeron, J. J. M. (1991) J. Biol. Chem. 266, 19599-19610). We show that p88 and calnexin share antigenic epitopes defined by a polyclonal anti-calnexin antiserum. Furthermore, both proteins were immunoprecipitated in association with an intracellularly retained variant of the class I H-2Kb molecule. Since p88 and calnexin were also indistinguishable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis, were resistant to digestion with endoglycosidase H, and exhibited virtually identical patterns of peptide fragments following digestion with either V8 protease or trypsin, we conclude that p88 and calnexin represent the same protein. The identification of the p88 chaperone as a phosphorylated, calcium-binding protein of the ER membrane suggests possible means whereby its interaction with class I molecules may be regulated.
Combined glycoprotein IIb/IIIa receptor inhibition and low‐dose fibrinolysis for peripheral arterial thrombosis (2002)

This feasibility study evaluated the therapeutic potential of combined GP IIb/IIIa receptor inhibition with abciximab and low-dose fibrinolysis with reteplase for treatment of acute femoropopliteal thrombosis. The simultaneous intra-arterial administration of abciximab in conjunction with low-dose reteplase (< or = 0.5 U/hr) was safe in 13 patients; 2 patients experienced major hemorrhagic complication at a reteplase dose of 1 U/hr. The primary success rate was 100%; all patients experienced an excellent clinical response with no clinical evidence of distal embolization. No patient required repeat endovascular or surgical revascularization during mean follow-up of 9.3 months. This promising new thrombolytic strategy for the treatment of peripheral arterial occlusive disease requires further study.
The prediction of coronary atherosclerosis employing artificial neural networks (2000)

The results of the current study, if reproduced in a larger population, may establish an integrated system based on the creation of artificial neural networks by which to predict the extent of atherosclerosis in a given subject fairly and noninvasively.
N-Nitroamides and N-Nitrocarbamates. IV. Rates of Decomposition. A Case of Steric Acceleration<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Nitroamides and N-Nitrocarbamates. IV. Rates of Decomposition. A Case of Steric Acceleration1Emil H. White and Lester A. DolakCite this: J. Am. Chem. Soc. 1966, 88, 16, 3790–3795Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/ja00968a020https://doi.org/10.1021/ja00968a020research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enrichment textures for detailed cutting of shells (2009)

We present a method for simulating highly detailed cutting and fracturing of thin shells using low-resolution simulation meshes. Instead of refining or remeshing the underlying simulation domain to resolve complex cut paths, we adapt the extended finite element method (XFEM) and enrich our approximation by customdesigned basis functions, while keeping the simulation mesh unchanged. The enrichment functions are stored in enrichment textures , which allows for fracture and cutting discontinuities at a resolution much finer than the underlying mesh, similar to image textures for increased visual resolution. Furthermore, we propose harmonic enrichment functions to handle multiple, intersecting, arbitrarily shaped, progressive cuts per element in a simple and unified framework. Our underlying shell simulation is based on discontinuous Galerkin (DG) FEM, which relaxes the restrictive requirement of C 1 continuous basis functions and thus allows for simpler, C 0 continuous XFEM enrichment functions.
Detection of courtesy amount block on bank checks (1996)

A multi-staged technique for locating the courtesy amount block on bank checks is presented. In the case of a check processing system, many of the proposed methods are not acceptable, due to the the presence of many fonts and text sizes, as well as the short length of many text strings. Particular methods chosen to implement a courtesy amount block locator (CABL) are described. First, the connected components in the image are identified. Next, strings are constructed on the basis of proximity and horizontal alignment of characters. Finally, a set of rules and heuristics are applied to these strings to choose the correct one. The chosen string is only reported if it passes a verification test, which includes an attempt to recognize the currency sign.