gebhart/patrepeval huggingface dataset:
Use of Host- and Bacteria-Derived Salivary Markers in Detection of Periodontitis: A Cumulative Approach (2011)

In the present study, we propose a novel diagnostic approach, using 3 different salivary markers, representing periodontal pathogen burden, inflammation, and tissue degradation, for detecting periodontitis. The salivary concentrations of Porphyromonas gingivalis , interleukin-1 β , and matrix metalloproteinase-8, available from salivary specimens of 165 subjects (84 subjects with advanced periodontitis and 81 controls), were calculated together to obtain a cumulative risk score (CRS). In the calculation of CRS, the concentrations of each marker were divided into tertiles, and cumulative sub-score per each subject were calculated by the multiplication of the tertile values. Three CRS groups, indicating the lowest, medium, or highest risk, were formed with the cumulative sub-scores. Logistic regression analysis and ROC curves were performed to study the association of CRS with periodontitis. The results indicate that CRS, calculated from the 3 salivary biomarkers, is associated with advanced periodontitis more strongly than any of the markers individually. CRS offers a novel, non-invasive model for advanced periodontitis risk categorization that is especially useful in large population surveys where a periodontal examination is not feasible.
Factors Affecting the Interactions of Collagen Molecules as Observed by in Vitro Fibril Formation (1972)

Mono, di-, and tri-saccharides were found to inhibit collagen fibril formation in vitro without denaturing collagen molecules. Polyalcohols such as ethylene glycol, glycerol, and mannitol also inhibited the fibril formation at higher concentrations than those of sugars. Urea and dioxane also inhibited the fibril formation, while acetone, dimethyl sulfoxide, and thiourea showed no inhibition. Addition of sodium dodecylsulfate (SDS) at a concentration of 0.004% stimulated the fibril formation and promoted recovery from inhibition by glucosamine, while SDS at concentrations higher than 0.05% inhibited the fibril formation because of its denaturing effect. The amount of SDS to stimulate collagen fibril formation was estimated as low as one SDS molecule to ten amino acid residues of a collagen molecule. The action of glucose on collagen molecules was demonstrated different from those of NaCl and urea, suggesting that glucose weakened the intermolecular forces which stabilize the collagen molecules in the fibril, while urea tended to dissociate “nuclei” in the process of collagen fibril formation.
Oral Norfloxacin for Prevention of Gram-Negative Bacterial Infections in Patients with Acute Leukemia and Granulocytopenia (1987)

We evaluated the effect of norfloxacin, 400 mg given orally every 12 hours, on the prevention of bacterial infections in 68 adult patients who had acute leukemia throughout prolonged courses of granulocytopenia (median, 32 days). Gram-negative infections were documented in 13 of the 33 patients receiving placebo, but only in 4 of the 35 patients receiving norfloxacin; no effect on the frequency of gram-positive or fungal infections was noted. Norfloxacin administration resulted in the suppression of gastrointestinal tract colonization by aerobic bacteria without the development of norfloxacin resistance. Patients receiving norfloxacin developed first infectious fevers later than did those receiving placebo, had more rapid resolution of that fever after systemic antibiotic treatment, and spent less time febrile. Therefore, although no difference was seen in survival duration, we found that the prophylactic administration of oral norfloxacin led to decreases in overall morbidity and gram-negative infections, was well tolerated, and did not predispose to the development of multiply drug-resistant bacteria.
Carotenoid Pigments in Red, Orange and Yellow Fleshed Fruits of Watermelon (Citullus vulgaris) Cultivars (1987)

The composition of carotenoids in three different flesh colored watermelon cultivars was studied. The carotenoids were separated by column and thin layer chromatography and identified by order absorption affinities on the column and by their absorption spectra. The contents and kinds of carotenoids were as follows;1. The red fleshed watermelon cultivar‘Asahiyamato’contained about 35-50μg/g lycopene as the major pigment; a small amount of xanthophylls and a slight amount of phytofluene, β-carotene, ρ-carotene and γ-carotene were present.2. The major pigment in orange fleshed watermelon cultivar‘Kaho’was β-carotene (14μ/g); phytofluene, ρ-carotene, γ-carotene, xanthophylls and lycopene were also present in small amounts.3. In the yellow fleshed watermelon cultivar‘Ogon, ’the main components was β-carotene (0.5μg/g) and xanthophylls(2μg/g); phytofluene and lycopene were detected in trace amounts.
Reaction products of organic dye molecules with acid-treated montmorillonite (1983)

Abstract During the reaction of solutions of the leuco dyes crystal violet lactone and N -benzoyl leuco methylene blue with acid-treated montmarillonite (as occurs with carbonless copying papers), most of the offered dye is intercalated within the interlayers of the montmorillonite structure remaining after acid attack. This phenomenon was demonstrated by XRD and also by high-resolution transmission electron microscopy. During acid treatment, octahedral cations are dissolved from exposed edges of the montmorillonite lamellae and amorphous silica builds up in these areas. As a result, the BET(N 2 ) specific surface area increases from ∼60 m 2 /g to ∼300 m 2 /g and, consequently, the theoretical reactivity towards leuco dyes. Nevertheless, only small quantities of the dye molecules are adsorbed onto the amorphous silica. The excellent colour intensity and, in particular, the resistance to fading in the light of the montmorillonite dye complexes may be explained by the protected position of the dye molecules within the interlayers of the montmorillonite.
Current Practice and Recent Commercial Developments in Flame Retardancy of Polyamides (2009)

No AccessFlame Retardants for Plastics and TextilesJul 2009Current Practice and Recent Commercial Developments in Flame Retardancy of PolyamidesEdward D. Weil, Sergei V. LevchikEdward D. Weil, Sergei V. Levchikhttps://doi.org/10.3139/9783446430655.005SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2009Pages: 85-104Print ISBN: 978-3-446-41652-9eISBN: 978-3-446-43065-5 Copyright & Permissions© 2009 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. (1990)

We have isolated a full-length cDNA clone encoding a protein (PRDII-BF1) that binds specifically to a positive regulatory domain (PRDII) of the human IFN-beta gene promoter, and to a similar sequence present in a number of other promoters and enhancers. The sequence of this protein reveals two novel structural features. First, it is the largest sequence-specific DNA-binding protein reported to date (298 kD). Second, it contains two widely separated sets of C2-H2-type zinc fingers. Remarkably, each set of zinc fingers binds to the same DNA sequence motif with similar affinities and methylation interference patterns. Thus, this protein may act by binding simultaneously to reiterated copies of the same recognition sequence. Although the function of PRDII-BF1 is not known, the level of its mRNA is inducible by serum and virus, albeit with different kinetics.
New approaches to pain (1980)

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Statistical modelling of a higher-order PMD emulator (2002)

A theoretical model of the statistical behaviour of a PMD emulator consisting of several rotatable linear birefringent elements in cascade enables the prediction of the emulator's PMD value for given rotation angles. Experimental results in good agreement with numerical simulations are presented for an emulator made of 10 calcite crystals.
[Role of DNA-dependent protein kinase catalytic subunit in silica-induced DNA double-strand break repair in human embryo lung fibroblasts]. (2009)

Silica can induce DNA double strand breaks in human embryo lung fibroblasts. DNA-PKcs might play a major role in silica-induced DNA double strand break repair. Silica-induced histone H2AX phosphorylation was dependent on DNA-PKcs.
Cyclic cholecystokinin analogues with high selectivity for central receptors. (1988)

Taking as a model the N-terminal folding of the cholecystokinin tyrosine-sulfated octapeptide [CCK-8; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2] deduced from conformational studies, two cyclic cholecystokinin (CCK) analogues were synthesized by conventional peptide synthesis: Boc-D-Asp-Tyr(SO3H)-Ahx-D-Lys-Trp-Ahx-Asp-Phe-NH2 [compound I (Ahx, 2-aminohexanoic acid)] and Boc-gamma-D-Glu-Tyr(SO3H)-Ahx-D-Lys-Trp-Ahx-Asp-Phe-NH2 (compound II). The binding characteristics of these peptides were investigated on brain cortex membranes and pancreatic acini of guinea pig. Compounds I and II were competitive inhibitors of [3H]Boc[Ahx28,31]CCK-(27-33) binding to central CCK receptors and showed a high degree of selectivity for these binding sites (compound I: Ki for pancreas/Ki for brain, 179; compound II: Ki for pancreas/Ki for brain, 1979). This high selectivity was associated with a high affinity for central CCK receptors (compound I: Ki, 5.1 nM; compound II: Ki, 0.49 nM). Similar affinities and selectivities were found when 125I Bolton-Hunter-labeled CCK-8 was used as a ligand. Moreover, these compounds were only weakly active in the stimulation of amylase release from guinea pig pancreatic acini (EC50 greater than 10,000 nM) and were unable to induce contractions in the guinea pig ileum (to 10(-6) M). The two cyclic CCK analogues, therefore, appear to be synthetic ligands exhibiting both high affinity and high selectivity for central CCK binding sites. These compounds could help clarify the respective role of central and peripheral receptors for various CCK-8-induced pharmacological effects.
Toward virtualizing branch direction prediction (2012)

This work introduces a new branch predictor design that increases the perceived predictor capacity without increasing its delay by using a large virtual second-level table allocated in the second-level caches. Virtualization is applied to a state-of-the-art multi-table branch predictor. We evaluate the design using instruction count as proxy for timing on a set of commercial workloads. For a predictor whose size is determined by access delay constraints, accuracy can be improved by 8.7%. Alternatively, the design can be used to achieve the same accuracy as a non-virtualized design while using 25% less dedicated storage.
Embedded memory hierarchy exploration based on magnetic RAM (2013)

SRAM, DRAM and FLASH are the three main employed technologies in design of on-chip processor memories. However, manufacturing constraints for this technologies in the most advanced nodes compromises further evolution. MRAM (Magnetic memory) presents itself as an attractive alternative for these technologies, as it has reasonable timing and power characteristics. Last results in the state of the art demonstrate that MRAM access time is can be less than 5ns and read/write energy per bit in same order of magnitude as SRAM, also it can evolve with the manufacturing process. One important feature of MRAM is the non-volatility, allowing to define new instant on/off policies and mainly optimizing leakage current. In this paper we demonstrate how MRAM can be used into memory hierarchy of embedded systems. The main objective is to demonstrate the interest to use MRAM for Level-1 & 2 cache and to better understand the architectural choice in order to minimize the impact of the higher write latency of MRAMs.
Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome (2012)

Synthetic biology has significantly advanced the design of genetic devices that can reprogram cellular activities and provide novel treatment strategies for future gene- and cell-based therapies. However, many metabolic disorders are functionally linked while developing distinct diseases that are difficult to treat using a classic one-drug-one-disease intervention scheme. For example, hypertension, hyperglycemia, obesity, and dyslipidemia are interdependent pathologies that are collectively known as the metabolic syndrome, the prime epidemic of the 21st century. We have designed a unique therapeutic strategy in which the clinically licensed antihypertensive drug guanabenz (Wytensin) activates a synthetic signal cascade that stimulates the secretion of metabolically active peptides GLP-1 and leptin. Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements. Based on this designer signaling cascade, it was possible to use guanabenz to dose-dependently control expression of GLP-1-Fc(mIgG)-Leptin, a bifunctional therapeutic peptide hormone that combines the glucagon-like peptide 1 (GLP-1) and leptin via an IgG-Fc linker. In mice developing symptoms of the metabolic syndrome, this three-in-one treatment strategy was able to simultaneously attenuate hypertension and hyperglycemia as well as obesity and dyslipidemia. Using a clinically licensed drug to coordinate expression of therapeutic transgenes combines drug- and gene-based therapies for coordinated treatment of functionally related metabolic disorders.
A SIMPLE WAY TO SYNCHRONIZE CHAOTIC SYSTEMS WITH APPLICATIONS TO SECURE COMMUNICATION SYSTEMS (1993)

In this paper, we provide a scheme for synthesizing synchronized circuits and systems. Synchronization of the drive and response system is proved trivially without the need for computing numerically the conditional Lyapunov exponents. We give a definition of the driving and response system having the same functional form, which is more general than the concept of homogeneous driving by Pecora & Carroll [1991]. Finally, we show how synchronization coupled with chaos can be used to implement secure communication systems. This is illustrated with examples of secure communication systems which are inherently error-free in contrast to the signal-masking schemes proposed in Cuomo & Oppenheim [1993a,b] and Kocarev et al. [1992].
An Urban Allocation Model Combining Time Series and Analytic Hierarchical Methods (1984)

Presented is a new application in urban economic forecasting. This method actively utilizes external information for household population forecasts. The purpose is to develop a more satisfying procedure as part of the management decision taking system. In the Portland Standard Metropolitan Statistical Area (SMSA), both time series and cross-sectional data are exploited. A transfer function-noise model is developed relating national output to SMSA employment. Household population for the SMSA is forecast utilizing the same statistical technique via a job opportunities/migration hypothesis. Forecasts are allocated to planning divisions within the SMSA by univariate stochastic models. However, these forecasts are adjusted after consideration of several land use indicators. The forecast standard errors are utilized and a hierarchical weighting scheme of the land-use indicators is developed within an allocation framework. Qualitative and quantitative information is merged to provide a more complete analysis and efficient estimates of the allocation weights.
Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis (2001)

Based on the notion that dimerization and/or variation of amino acid 1 of vancomycin could potentially enhance biological activity, a series of synthetic and chemical biology studies were undertaken in order to discover potent antibacterial agents. Herein we describe two ligation methods (disulfide formation and olefin metathesis) for dimerizing vancomycin derivatives and applications of target-accelerated combinatorial synthesis (e.g. combinatorial synthesis in the presence of vancomycin's target Ac2-L-Lys-D-Ala-D-Ala) to generate libraries of vancomycin dimers. Screening of these compound libraries led to the identification of a number of highly potent antibiotics effective against vancomycin-suspectible, vancomycin-intermediate resistant and, most significantly, vancomycin-resistant bacteria.
Synthesis of 3,3′-bi-1,2,4-Triazolo[4,5-a]- benzimidazole, 5,5′-bi-1,3,4-Thiadiazole, and Thiazolo[3,2-a]benzimidazole Derivatives (2003)

A series of novel 3,3′-bi-1,2,4-triazolo[4,5-a]benzimidazole and thiazolo[3,2-a]-benzimidazole derivatives were synthesized via the reaction of bis-hydrazonoyl chlorides with 2-methylthiobenzimidazole and with benzimidazol-2-thiol, respectively. A direct synthesis of 5,5′-bi-1,3,4-thiadiazole and 4,5-bis-phenylhydrazono-2,3,4,5-tetrahydrothiazole derivatives is also described.
Model order-reduction of RC(L) interconnect including variational analysis (1999)

Article Model order-reduction of RC(L) interconnect including variational analysis Share on Authors: Ying Liu Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PAView Profile , Lawrence T. Pileggi Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PAView Profile , Andrzej J. Strojwas Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA Department of Electrical and Computer Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PAView Profile Authors Info & Claims DAC '99: Proceedings of the 36th annual ACM/IEEE Design Automation ConferenceJune 1999 Pages 201–206https://doi.org/10.1145/309847.309914Online:01 June 1999Publication History 44citation390DownloadsMetricsTotal Citations44Total Downloads390Last 12 Months14Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Process Intensified Flow Synthesis of 1<i>H</i>-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir (2015)

Herein we present a high-temperature/high-pressure continuous flow synthesis of 1H-4-substituted imidazoles starting from α-bromoacetophenones and carboxylic acids. 1H-4-aryl imidazoles are key building blocks in the synthesis of NS5A inhibitors, including daclatasvir as the most prominent example. The reaction sequence started with the generation of the α-acyloxy ketone from α-bromoacetophenone and the carboxylic acid. The subsequent condensation to the 1H-4-substituted imidazole was performed with ammonium acetate in a high-temperature stainless steel coil reactor. High-temperature operation (> ∼ 150 °C) was essential for this reaction to form the desired imidazole in high purity. Intensification of chemical reactions in continuous flow reactors has emerged as key enabling technology for process enhancement and for reducing the environmental impact of chemical processes. The continuous flow setup allowed rapid heating of the reaction mixture to the desired temperature. Furthermore, operation at elevated pressure (∼17 bar) eliminated headspace and increased the concentration of volatile compounds in the liquid phase. The imidazole formation was completed in the coil reactor after residence times of only 2 to 5 min. The products were isolated after the two step reaction sequence in high purity by a simple extraction procedure. Imidazoles derived from chiral amino acids were obtained as the optically pure compounds.
Enhancing Privacy and Authorization Control Scalability in the Grid Through Ontologies (2009)

The use of data Grids for sharing relevant data has proven to be successful in many research disciplines. However, the use of these environments when personal data are involved (such as in health) is reduced due to its lack of trust. There are many approaches that provide encrypted storages and key shares to prevent the access from unauthorized users. However, these approaches are additional layers that should be managed along with the authorization policies. We present in this paper a privacy-enhancing technique that uses encryption and relates to the structure of the data and their organizations, providing a natural way to propagate authorization and also a framework that fits with many use cases. The paper describes the architecture and processes, and also shows results obtained in a medical imaging platform.
Energy-efficient scheduling of delay constrained traffic over fading channels (2008)

A delay-constrained scheduling problem for point-to-point communication is considered: a packet of B bits must be transmitted by a hard deadline of T slots over a time-varying channel. The transmitter/scheduler must determine how many bits to transmit, or equivalently how much energy to transmit with, during each time slot based on the current channel quality and the number of unserved bits, with the objective of minimizing expected total energy. In order to focus on the fundamental scheduling problem, it is assumed that no other packets are scheduled during this time period and no outage is allowed. Assuming transmission at capacity of the underlying Gaussian noise channel, a closed-form expression for the optimal scheduling policy is obtained for the case T = 2 via dynamic programming; for T > 2, the optimal policy can only be numerically determined. Thus, the focus of the work is on derivation of simple, near-optimal policies based on intuition from the T = 2 solution and the structure of the general problem. The proposed bit-allocation policies consist of a linear combination of a delay-associated term and an opportunistic (channel-aware) term. In addition, a variation of the problem in which the entire packet must be transmitted in a single slot is studied, and a channel-threshold policy is shown to be optimal.
Image interpolation with directionlets (2008)

We present a novel directionally adaptive image interpolation based on a multiple-direction wavelet transform, called directionlets. The algorithm uses directionlets to efficiently capture directional features and to extract edge information along different directions from the low-resolution image. Then, the high-resolution image is generated using this information to preserve sharpness of details. Our interpolation algorithm outperforms the state-of-the-art methods in terms of both numeric and visual quality of the interpolated image.
Machine condition monitoring using neural networks and the likelihood function (1997)

A model-based technique incorporating neural networks has been developed for process monitoring. The technique is intended for processes where the uncertainty in the reference model is larger than desired but where process measurements providing additional information about the behavior of the system are available. This data is used to reduce the uncertainty of the model. The technique has been implemented in a real-time system for monitoring operational changes of mechanical equipment for use in predictive maintenance applications. Tests on a peristaltic pump were conducted and demonstrate the advantages of the proposed technique.