gebhart/patrepeval huggingface dataset:
Accurate and analytical statistical spatial correlation modeling for VLSI DFM applications (2008)

With the significant advancement of statistical timing and yield analysis algorithms, there is a strong need for accurate and analytical spatial correlation models. In this paper, we propose a novel spatial correlation modeling method not only can capture the general spatial correlation relationship but also can generate highly accurate and analytical models. Our method, based on Singular Value Decomposition (SVD), can generate sequences of polynomial weighted by the singular values. Experimental results from foundry measurement data show that our proposed approach is 5X accuracy improvement over several distance based spatial correlation modeling methods.
Building DITA-based CMS as integrated documentation environment (2012)

General software documents have some problems with traceability and maintenance. This study aims to solve those problems by using DITA, an XML-based architecture for authoring technical documents. In DITA architecture, documents consist of topics and maps. Topics have small amount of information which can reuse, and maps specify contents of each output by organizing topics. It is difficult to break down general documents into reusable topics. In this paper, granularity of topics are defined. As a result of analysis of software documents, it was found that there are three types of structures in software documents, and those need to be broken down into different-sized topics. Besides, a CMS as a software documentation environment is needed for software documentation using DITA. Functions required for the CMS are considered.
A large air gap 3 kW wireless power transfer system for electric vehicles (2012)

A wireless power transfer system for electric vehicles is required to have high efficiency, a large air gap, and good tolerance for misalignment in the lateral direction and to be compact and lightweight. A new 3 kW transformer has been developed to satisfy these criteria using a novel H-shaped core and split primary capacitors. The design procedure based on the coupling factor k, the winding's Q, and the core loss is described. An efficiency of 90% was achieved across a 200 mm air gap.
Outcome‐related Performance Indicators and Organizational Control in the Public Sector<sup>1</sup> (1993)

SUMMARY There is increased interest in the widespread dissemination of outcome performance data to secure enhanced strategic control of public sector organizations. This paper adumbrates the rationale for such schemes, and outlines the potential distortions induced by excessive reliance on outcome‐related performance indicators, inferred from experience in the management control and Soviet literature. The paper gives an outline of the performance review process in the United Kingdom National Health Service, and presents the results of a case study of the impact of the publication of outcome performance data in the maternity services. The research detected many of the expected distortions arising from reliance on performance indicator schemes, and concludes that they may have significant dysfunctional consequences. The paper does not however advocate the abandonment of performance audit in the public sector. Instead, it warns that great attention should be given to the managerial incentives implicit in any strategic control scheme, and that the style with which the scheme is applied will have important bearings on its effectiveness.
In vitro activity of fludalanine combined with pentizidone compared with those of other agents (1984)

The in vitro activity of fludalanine ( MK641 ) combined with pentizidone ( MK642 ) so as to give a fludalanine /D-cycloserine ratio of 1:1 was compared with the activities of ampicillin, ticarcillin, cefuroxime, ceftazidime, and trimethoprim against 452 recent isolates and known beta-lactam- and trimethoprim-resistant strains. In addition, the in vitro activity of fludalanine - pentizidone on four different media, including a defined medium ( DFN -2), was studied. The MIC of fludalanine - pentizidone against 90% of Escherichia coli, Klebsiella spp., Enterobacter spp., Providencia stuartii, Haemophilus influenzae, Neisseria gonorrhoeae, Staphylococcus aureus, and fecal streptococci was 4 micrograms or less per ml on DFN -2, and activity was somewhat reduced on the other media. Proteus spp. and Pseudomonas aeruginosa (90% MIC, less than or equal to 64 micrograms/ml) and Bacteroides spp. (90% MIC, 16 micrograms/ml) were less susceptible. Generally, fludalanine - pentizidone was less active than ceftazidime and comparable in activity to cefuroxime. beta-Lactamase-producing and trimethoprim-resistant strains tended to be susceptible to fludalanine - pentidizone . In the absence of human serum, the MBC of fludalanine - pentizidone was similar to the MIC. In the presence of increasing concentrations of human serum, there tended to be a greater difference between the MIC and MBC.
Granulocyte-Macrophage Colony-Stimulating Factor and B7-2 Combination Immunogene Therapy in an Allogeneic Hu-PBL-SCID/Beige Mouse–Human Glioblastoma Multiforme Model (1997)

Glioblastoma multiforme is the most common primary central nervous system neoplasm. Its dismal prognosis has led to investigation of new treatment strategies such as immunogene therapy. We transduced the human glioblastoma cell line D54MG in vitro with genes encoding the proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), the T cell co-stimulatory molecule B7-2, or both (in a bicistronic vector) via retroviral vectors. Therapeutic gene expression by D54MG was high after transduction and selection (30 ng/10(6) cells/day for GM-CSF and > 2 orders of magnitude fluorescence shift on flow cytometry for B7-2). The effect of GM-CSF and/or B7-2 transduction on D54MG tumor growth in vivo was monitored in a novel allogeneic human peripheral blood lymphocyte-severe combined immunodeficiency mouse (Hu-PBL-SCID) model. GM-CSF- or B7-2-transduced tumors showed growth suppression in hu-PBL-reconstituted mice compared to untransduced and/or unreconstituted controls. Growth suppression was greatest for B7-2. Furthermore, vaccination with irradiated GM-CSF/B7-2-transduced tumor cells markedly inhibited growth of wild-type tumors at distant sites. Thus, this study illustrates a potential gene therapy strategy for glioblastoma multiforme patients using GM-CSF and/or B7-2 transduced tumor vaccines. Although extension of these allogeneic studies to an autologous system is critical, this is the first demonstration of in vivo efficacy of combination GM-CSF and B7-2 immunogene therapy for human glioblastoma multiforme.
[A multicenter clinical study of oral topical administration of G-512 on chemotherapy-associated intraoral mucosal lesions of patients with hematological malignancies. G-512 Therapeutic Study Group for Intraoral Mucosal Lesions]. (1990)

We evaluated the usefulness of PGE2 on chemotherapy-associated oral mucosal lesions of the patients with hematological malignancies and compared the efficacy of the troche with that of the tablet. One hundred and fifty three patients were given 0.5 mg of these PGE2 topically three times daily. One hundred and fourty five cases were evaluable (Tablet; 85, Troche; 60). 1) Symptoms and signs were improved in 102/144 (70.8%) and 102/145 (70.3%), respectively. The overall response rate was 70.3%. 2) The improvement rates were 77.5% (55/71), 85.7% (6/7) and 62.7% (32/51) in leukocyte count-increased, -unchanged and -decreased patients, respectively. 3) No background factor of the patients except performance status affected the improvement rate. 4) Higher improvement rate was noted in the PGE2 early starting group (within 5 days after the appearance of oral lesions) than the late group (6 days and thereafter) (76.5% v.s. 55.8%: U-test p less than 0.1, chi2-test p less than 0.05). 5) There was no difference in the efficacy rate between the tablet and the troche. 6) Mild side effects were seen in 10 cases. These results suggest that topical administration of PGE2 is safe and useful for improving chemotherapy-associated oral mucosal lesions of patients with hematological malignancies.
Anti-VCAM-1 Antibodies did not Protect against Ischemic Damage Either in Rats Or in Mice (2005)

Cerebral ischemia triggers an inflammatory process involving the infiltration of leukocytes to the parenchyma. Circulating leukocytes adhere to the vascular wall through adhesion molecules. Here we quantified the in vivo expression of vascular cell adhesion molecule-1 (VCAM-1) in the brain, heart and lungs from 6 to 48 h after transient middle cerebral artery (MCA) occlusion in rats, by intravenous injection of a tracer radiolabelled anti-VCAM-1 antibody. The vascular localization of VCAM-1 was verified by immunohistochemistry after in vivo injection of the antibody. Vascular cell adhesion molecule-1 was strongly induced (4-fold at 24 h) in the microvasculature of the ischemic area, and, to a lesser extent, in the contralateral hemisphere and in a remote organ, the heart, but not in the lungs, indicating that the inflammatory process propagates beyond the injured brain. We injected intravenously either blocking doses of anti-VCAM-1 antibodies or control antibodies after MCA occlusion in rats and mice. We evaluated the neurological score in rats, and infarct volume at 2 days in rats and at 4 days in mice. Anti-VCAM-1 did not protect against ischemic damage either in rats or in mice. Vascular cell adhesion molecule-1 blockade significantly decreased the number of ED1 (labeling monocytes /macrophages/reactive microglia)-positive cells in the ischemic rat brain. However, it did not reduce the numbers of infiltrating neutrophils and lymphocytes, and total leukocytes (CD45 positive), which showed a trend to increase. The results show vascular upregulation of VCAM-1 after transient focal ischemia, but no benefits of blocking VCAM-1, suggesting that this is not a therapeutical strategy for stroke treatment.
GPU-based Orthorectification of Digital Airborne Camera Images in Real Time (2008)

The usage of airborne camera systems for near real time applications will increase in the near future. This paper purposes a new\nhardware/software architecture to establish real time computation of images obtained from the DLR wide area airborne 3K-camera\nsystem. The main applications of our system are e.g. to monitor automotive traffic, to determine the workload of public road\nnetworks during mass events, or to obtain a survey of damages in disaster areas in real time. Therefore, many different image\nprocessing tasks have to be executed in real time. Orthorectification of images is necessary prior to all other processing tasks, e.g.\nbefore mapping data from street data bases into images or before tracking of vehicles. Nowadays, the calculation becomes possible\ndue to fast graphic processing units (GPU) and with the support of a distributed real time system. In order to achieve real time image\nprocessing, we suggest a GPU-based algorithm for image orthorectification. The GPS/IMU-system provides the position and\norientation of the aircraft with 128Hz quite accurately. Assuming synchronized measurements with the camera system and given\ncamera calibration, direct orthorectification is implemented using OpenGL. Therewith, we are able to process high resolution images\nconsisting of 16 MPixels with a frame rate of 3 Hz. This paper describes the implementation of the real time algorithm and gives first\nresults.
An enhanced bandwidth design technique for electromagnetically coupled microstrip antennas (2000)

This paper describes a method of enhancing the bandwidth of two different electromagnetically coupled microstrip antennas by utilization of a tuning stub. An approximate theory and equations are developed to demonstrate the potential bandwidth improvement and required stub impedance characteristics. A novel dual-stub design is presented that achieves better characteristics than a conventional quarter wavelength open-end stub. As examples, the bandwidth (VSWR<2) of a conventional proximity-coupled microstrip antenna is increased from 4.8 to 8.4% and the bandwidth of a stacked aperture-coupled microstrip antenna is increased from 27.5 to 34.5% using this technique.
Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases (1999)

The isoxazole derivative Leflunomide (HWA 486) is a novel immunoregulatory and anti-inflammatory drug. Affinity chromatography was used to purify and identify Leflunomide binding proteins, which might play a role as potential cellular targets in the molecular mode of action. The Leflunomide derivative A 0273 was covalently coupled to a Fractogel(R) matrix. This column was used to separate a cytosolic protein extract of the macrophage cell line RAW 264.7 by several selected and specific gradient elution steps. Proteins that were specifically eluted through the active metabolite of Leflunomide, A 1726, were identified by subsequent protein sequence analysis. This allowed us to specify 10 cytosolic proteins, which bind with high affinity to this matrix. Three of them, glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase and phosphoglycerate mutase belong to the second part of the glycolytic pathway. The binding specificity of these protein/drug interactions was further evaluated using BIAcore(R) analysis. Kd values of glyceraldehyde 3-phosphate dehydrogenase, pyruvate kinase and lactic dehydrogenase were similar to the Kd value of a known Leflunomide target protein, dihydroorotate dehydrogenase. In order to elucidate the features as well as the overall relevance of these results, cytosolic fractions of three additional cell lines MOLT-4, A20.2J, HeLa were compared using the same chromatographic protocol. The elution profiles as well as subsequent Western blot analyses confirmed the data obtained previously for the macrophage cell line RAW 264.7.
FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor-Suppressive miR-342 in Human Colorectal Cancer (2016)

Collectively, we have firstly identified FOXM1 and FOXQ1 as promising prognostic biomarkers in colorectal cancer patients, and provided novel evidence that therapeutic targeting of these genes or miR-342 may be a potential treatment approach in colorectal cancer patients. Clin Cancer Res; 22(19); 4947-57. ©2016 AACR.
An n-well CMOS with self-aligned channel stops (1983)

A new n-well CMOS structure is described in which the performance of the n-channel MOSFETs can be optimized. This structure also provides self-aligned channel stops to offer rigorous isolation for high density ICs. A novel process was developed to fabricate the structure. Extremely low body effect coefficients (γ=0.1-0.2) are obtained from the resulting n-channel MOSFETs with 1.25µm channel length. Moreover even at 10V, subthreshold currents in the isolation region between two similar or two opposite type FETs are < 1 pA.
Destruction of volatile organic compounds used in a semiconductor industry by a capillary tube discharge reactor (1998)

Nonthermal plasma technologies offer an innovative approach to the problem of decomposing various volatile organic compounds (VOCs). The authors focused on DC capillary tube discharge plasma reactors to study the decomposition/destruction efficiency for toluene, EGM, trichloroethane and trichloroethylene at 50-2300 ppm levels in dry air. The effects of gas flow rate, VOC concentration and reactor operating conditions on decomposition and analysis of reactant conversion for each VOC were investigated. The results show that VOC destruction efficiency as high as 90% can be achieved, even under a short residence time (3.8 ms) with a destruction energy efficiency of up to 95 g (VOC)/kWh. Laboratory-scale plasma technology was successfully demonstrated for its potential application for VOC control in the semiconductor clean-room environment.
Patchwork Peptide Sequencing (2003)

The advent of new analyzer systems based on Fourier-transform ion cyclotron resonance (FT-ICR) and quadropole time-of-flight (Q-TOF) technologies allows protein digests to be analyzed under high-resolution conditions, resulting in mass spectometry (MS) and tandem MS (MS/MS) peptide mass spectra characterized by a resolution of 10,000 [full width half-maximum (FWHM) definition] or better. From mass spectra recorded under these conditions, the m/z values of peptides can be measured with mass errors between somewhat below 1 ppm and 50 ppm, depending mainly on the type of instrument used, the sample purity, the signal intensity, and the mode of calibration employed.
Possible contribution of aprepitant to ifosfamide-induced neurotoxicity (2008)

A 24-year-old patient treated with ifosfamide, carboplatin, and etoposide for a malignant peripheral nerve sheath tumor developed ifosfamide-induced neurotoxicity after the addition of aprepitant to a standard antiemetic regimen consisting of ondansetron and dexamethasone.
Optical technologies — an agenda for the future (1987)

Roger Main gives a four‐part report on the optical technologies which are playing an increasingly important role in sensor development.
Estimating and interpreting the waiting time for customers arriving to a non-stationary queueing system (2015)

When a customer arrives to a service system, how long should they expect to wait, and how long might their wait actually be? Computer simulation is an ideal tool for answering such questions for very general and complex queueing systems, but they are not always answered by the automatic statistical summary generated by commercial simulation languages. Using an illustration based on passenger check-in at an airport, we demonstrate how standard summary measures go wrong and provide methods that correctly answer these questions.
Production of membrane proteins using cell–free expression systems (2007)

Different overexpression systems are widely used in the laboratory to produce proteins in a reasonable amount for functional and structural studies. However, to optimize these systems without modifying the cellular functions of the living organism remains a challenging task. Cell-free expression systems have become a convenient method for the high-throughput expression of recombinant proteins, and great effort has been focused on generating high yields of proteins. Furthermore, these systems represent an attractive alternative for producing difficult-to-express proteins, such as membrane proteins. In this review, we highlight the recent improvements of these cell-free expression systems and their direct applications in the fields of membrane proteins production, protein therapy and modern proteomics.
The Effect of Vitamin E Supplementation of Cow Diets Containing Rapeseed and Linseed on the Prevention of Milk Fat Oxidation (1998)

Two experiments involving lactating Holstein cows were carried out to quantify the effect of a 550-g supplement of lipids from extruded rapeseed and linseed on milk fatty acid profiles and the susceptibility of milk fat to oxidation. The effect of a daily oral supplement containing 9616 IU of vitamin E (all-rac-alpha-tocopheryl acetate) on milk alpha-tocopherol and protection against oxidation was also evaluated. The intake of oilseeds decreased protein and fat contents in milk, and the proportion of all C18 fatty acids increased. The trans isomers were 2.7 and 10.76% of the milk fatty acids, respectively, for cows fed the control diet and the diet containing extruded rapeseed and linseed. The ratio of oleic to palmitic acid was doubled, and the resistance to oxidation was reduced by 30 to 40% in both experiments. The dietary vitamin E supplement increased the alpha-tocopherol concentration in milk by about 45% and was sufficient to prevent milk fat depression and oxidation. The diet containing oilseeds and supplemented with an adequate amount of vitamin E allowed cows to yield milk that could be used to manufacture butter with high oleic acid content, good spreadability, and resistance to oxidation.
Automatic 3D model building from video sequences (1997)

Abstract We describe progress on automating the construction of 3D geometric models from video sequences. The system we are developing allows a person to walk around a room with a video camera, and from the video sequence alone extract a 3D model of the room. The room can then be graphically rendered together with possible arrangements of previously modelled objects, e.g. CAD models of furniture. The system is designed to ease model acquisition for virtual reality and telepresence applications, however the approach also has application in model based image coding. The approach is based on recent work in computer vision where image primitives are extracted and matched through an image sequence. For example, the simultaneous estimation of epipolar geometry and image corner correspondences. The matching techniques are both robust (detecting and discarding mismatches) and fully automatic. No knowledge of the camera (e.g. its focal length) or motion is required. 3D structure is computed from the matched image primitives (corners, lines and texture). The structure is then triangulated and texture is mapped onto the triangles from intensities in the images. Experimental results are provided for a variety of scenes, including isolated objects acquired with a standard CCD camera, and outdoor scenes acquired with a hand‐held camcorder.
Multi-criteria Optimization System for Decision Making in Construction Design and Management (2009)

All new ideas and possible variants of decisions mustbe compared according to many criteria. The complexnature of decision-making requires practitioners to selectinvestment options based on a wider variety of policyconsiderations in addition to cost benefit analysis and puretechnical considerations. In economics and decisionmaking it is essential to be able to take into account theimpacts of cultural, social, moral, legislative, demographic,economic, environmental, governmental and technologicalchange, as well as changes in the business world oninternational, national, regional and local markets. Costbenefit analysis approach is a useful tool for investmentdecision-making from an economic perspective. Cautionsshould also be given to the methods of determining thevalue of social and local interests. Some socialexternalities, such as employment and regional economicimpacts, are generally omitted in current practices.Current practices tend to use cardinal or ordinal scales inmeasure in non-monetized criteria. The use of unreasonablemonetization methods in some cases has discredited costbenefit analysis in the eyes of decision makers and thepublic. It may be appropriate to consider these externalities inqualitative forms in a multi-criteria analysis. Multi-criteriadecision making is used in various areas of humanactivities. The Criteria can be qualitative and quantitative.They usually have different units of measurement anddiffer in optimization direction. The normalization aims atobtaining comparable scales of criteria values. In the newversion of the program LEVI 4 the normalization methodsare including vector, linear scale, non-linear and newlogarithmic techniques may be used. This softwareconsiders the main aspects of two-sided game problems.The following strategic principles are used: Wald's rule,Savage criterion, Hurwicz's rule, Laplace's rule, Bayes'srule and Hodges-Lehmann rule. This program isdemonstrated by considering a real case study involving 4evaluation criteria of the currently used external walls ofindividual residential buildings.