gebhart/patrepeval huggingface dataset:
Detection of Trisomy 12 on Ovarian Sex Cord Stromal Tumors by Fluorescence In Situ Hybridization (1993)

Trisomy of chromosome 12 has been frequently described in various neoplasms, particularly in tumors of the female genitourinary tract. Fluorescence in situ hybridization with a centromeric repetitive DNA probe, specific for chromosome 12, was done to detect such cytogenic changes on frozen-tissue sections from 10 cases of ovarian sex cord stromal tumors. The case series was composed by granulosa cell tumors (four cases), fibromas (four cases), thecoma (one case), and Sertoli-Leydig cell tumor (one case). In granulosa cell tumors, the range of trisomy was 12 to 32% and in fibromas 8 to 22%, whereas in the single case of thecoma trisomy was present in 8% and in the Sertoli-Leydig cell tumor in 4% of the nuclei examined. These results represent an additional series of cases of trisomy 12 in ovarian neoplasms, namely, in ovarian sex cord stromal tumors.
A novel 51‐kDa fragment of the large subunit of ribulose‐1,5‐bisphosphate carboxylase/oxygenase formed in the stroma of chloroplasts in dark‐induced senescing wheat leaves (2007)

The degradation of large subunit (LSU) of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) in wheat (Triticum aestivum L. cv. Yangmai 158) leaves was studied. A novel 51-kDa fragment was detected in leaf crude extracts and in chloroplast lysates from leaves with dark-induced senescence. Further studies showed that the 51-kDa fragment was found in the reaction solution with stroma fraction but not in that with the chloroplast membrane fraction and in the chloroplast lysates from mature wheat leaves. The reaction of producing the 51-kDa fragment was inhibited by 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF), 1,10-phenanthroline and EDTA. The N-terminal sequence analysis indicated that the LSU was cleaved at the peptide bond between Lys-14 and Ala-15. In addition, a 50-kDa fragment of LSU formed obviously at pH 6.0-6.5 was detected in the crude extracts of leaves with dark-induced senescence but was not found in lysates of chloroplasts. The degradation was prevented by AEBSF, leupeptin and transepoxysuccinyl-l-leucylamido (4-guanidino) butane (E-64). The results obtained in this study imply that the appearance of the 51-kDa fragment could be because of the involvement of a new senescence-associated protease that is located in the stroma of chloroplasts in senescing wheat leaves.
Antigenic glycolipids of Mycobacterium fortuitum based on trehalose acylated with 2-methyloctadec-2-enoic acid (1993)

Three characteristic glycolipids were identified in extracts of 10 representative strains of Mycobacterium fortuitum. The two most polar major lipids were shown to be antigens with strong reactions against homologous antiserum and sera raised against Mycobacterium tuberculosisH37Rv. Both of these lipids were shown to be acyl trehaloses, containing substantial amounts of 2‐methyloctadec‐2‐enoic acid in addition to straight‐chain and monounsaturated acids. These lipids correspond to ‘mycoside F’, lipids previously identified by infra‐red spectroscopy in extracts of Myco. fortuitum.
Integrated transrectal probe for translational ultrasound-photoacoustic imaging (2016)

A compact photoacoustic transrectal probe is constructed for improved imaging in brachytherapy treatment. A 192 element 5 MHz linear transducer array is mounted inside a small 3D printed casing along with an array of optical fibers. The device is fed by a pump laser and tunable NIR-optical parametric oscillator with data collected by a Verasonics ultrasound platform. This assembly demonstrates improved imaging of brachytherapy seeds in phantoms with depths up to 5 cm. The tuneable excitation in combination with standard US integration provides adjustable contrast between the brachytherapy seeds, blood filled tubes and background tissue.
Toward organic desulfurization. The treatment of bituminous coals with strong bases (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward organic desulfurization. The treatment of bituminous coals with strong basesKuntal Chatterjee and Leon M. StockCite this: Energy Fuels 1991, 5, 5, 704–707Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ef00029a013https://doi.org/10.1021/ef00029a013research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Real-image-based autostereoscopic display using LCD, mirrors, and lenses (2003)

The author presents a new version of FLOATS (Flesnel-Lens-based Optical Apparatus for Touchable-distance Stereoscopy) system. The autostereoscopic display FLOATS combines parallax presentation and real image generation by lenses to show realistic 3-D images within the reach of the viewer. In the conventional FLOATS, polarizing filters or liquid crystal shutters are used to separate images projected to the eyes, which has caused cross-talk noise and reduction of brightness. This paper proposes use of combined mirrors instead of filters or shutters to realize parallax presentation. In this system the images for the right eye and the left eye are displayed side by side on the screen. Then the combined mirrors reflect each image to shift it to the center so that the optical geometry of this system may be completely the same as the conventional FLOATS display. This new method avoids both cross-talk noise and reduction of brightness and enables presentation of more realistic 3-D image which gives less eyestrain to the viewer. In addition to it, a LCD panel can be used as the screen part of this system because it is only required to show two images side by side. As a result the size of the system is reduced compared with the conventional system.
Cellular immune parameters associated with improved long-term survival in advanced stage breast cancer patients after active immunization with a HER2-specific vaccine (2008)

3015 Background: Clinical trials of HER2 vaccines have demonstrated that breast cancer patients can be immunized against HER2 and HER2-specific T cells persist long after vaccination. Immunization with HER2 vaccines is associated with the development of epitope spreading; a broadening of immunity to epitopes throughout the HER2 protein. We evaluated the clinical impact of vaccine induced HER2 specific cellular immunity in breast cancer patients immunized with HER2 vaccines. Methods: 75 subjects from 3 phase I-II vaccine trials were analyzed. T cell responses to HER2 peptides, intracellular (ICD) protein and tetanus toxoid (TT) were assessed by tritiated thymadine incorporation. Subjects were included in the analysis if they had complete baseline labs and received at least three vaccinations. Any SI >2.0 was considered positive. Epitope spreading was defined as a positive post-vaccination response to a non-vaccinating peptide. In addition, the relationship between T cell response and overall survival (OS) was assessed (n=50). Patients were followed a median of 2.7 years. Results: There was a significant difference in level of HER2 ICD immunity after vaccination between stages. There were also significant differences in peptide specific SI (p=0.034) and presence of epitope spreading (p=0.006) between stages. HER2 peptide-specific SI was a significant predictor of epitope spreading (p=0.031). Subjects with epitope spreading had significantly higher peptide responses (mean SI: 11.5) than subjects without epitope spreading (mean SI: 3.3) (p<0.001). Univariate analysis demonstrated patients with epitope spreading had longer OS than patients without epitope spreading (p=0.029, HR=0.50), and increased HER2, but not TT, specific T cell immunity, was associated with improved survival (p=0.025, HR=0.94). Multivariate analysis indicated that HER2, but not TT, specific T cell immunity, was an independent variable (p=0.021, HR=0.86) for prediction of OS in advanced stage subjects. Conclusions: These data suggest that vaccine-induced HER2 specific cellular immune response, with epitope spreading, may have clinical benefit and should be further evaluated in the context of phase II studies. No significant financial relationships to disclose.
End-to-end YANG-based configuration management (2010)

Networked resources are of increasing complexity and have to be configured properly to guarantee their operation. Within the IETF, current efforts are focused on both a protocol and a data model definition language for configuration management. The NETCONF protocol describes the communication between devices to be configured and configuration applications. NETCONF does not describe how configuration data is represented. This is addressed by the YANG data modeling language, the emerging proposal of the netmod standard working group.
A GPU‐based Streaming Algorithm for High‐Resolution Cloth Simulation (2013)

Abstract We present a GPU‐based streaming algorithm to perform high‐resolution and accurate cloth simulation. We map all the components of cloth simulation pipeline, including time integration, collision detection, collision response, and velocity updating to GPU‐based kernels and data structures. Our algorithm perform intra‐object and inter‐object collisions, handles contacts and friction, and is able to accurately simulate folds and wrinkles. We describe the streaming pipeline and address many issues in terms of obtaining high throughput on many‐core GPUs. In practice, our algorithm can perform high‐fidelity simulation on a cloth mesh with 2M triangles using 3GB of GPU memory. We highlight the parallel performance of our algorithm on three different generations of GPUs. On a high‐end NVIDIA Tesla K20c, we observe up to two orders of magnitude performance improvement as compared to a single‐threaded CPU‐based algorithm, and about one order of magnitude improvement over a 16‐core CPU‐based parallel implementation.
Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo (2010)

Together, these observations point to an essential role of APP intracellular domain for normal APP processing and function in vivo, and provide rationale for further studies into physiological functions associated with this important phosphorylation site.
Explorations in tag suggestion and query expansion (2008)

The query used in a search system is only an approximation to the user's true information need, and as a result, many factors can reduce the quality of search results. One is query ambiguity, causing searchers with different needs to issue the same query. For example, for the query java, some users may want to find java tutorial while others may want to download java software. Other factors include a vocabulary mismatch and a lack of knowledge regarding the contents of the document collection. In any case, many users benefit from assistance in forming a good query. As a result, some commercial services provide query suggestions for many queries.In this paper, we propose a Tag Suggestion System that takes advantage of tags associated with query results to expand a searcher's query. Since not every web page is associated with existing tags, we first build an auto-tagging system which can assign multiple tags to web pages, including news, blogs, etc. The current system contains the most popular 140 tags in del.icio.us, with high precision performance.A small user study is performed to evaluate anecdotally the performance of our Tag Suggestion System, showing better quality than the query suggestion mechanisms provided by Yahoo! and Google. The result pages of expanded queries generated by the Tag Suggestion System are also significantly better than those of the Google original system.
Nicotinic stimulant action of some tolyl and xylyl analogues of 1,1‐dimethyl‐4‐phenylpiperazinium (DMPP) (1971)

1. The nicotinic stimulant properties of DMPP have been compared with those of its ortho-, meta- and para-tolyl analogues, and its 2,6- and 3,5-xylyl analogues, on the blood pressure of the cat and on the semispinalis cervicis muscle of the chick.2. A single ortho-methyl group does not significantly change the nicotinic activity, but two such groups greatly reduce or abolish activity. Meta- or para-methyl substitution reduces activity, but does not abolish it.3. The effect on nicotinic activity of methyl substitution in the phenyl ring of DMPP closely parallels the effect of ring-methyl substitution in phenyl choline ether.4. Ortho-methyl substitution has been shown spectroscopically to alter markedly the spatial orientation of the phenyl ring of DMPP relative to the piperazine ring. The effect of these conformational changes on nicotinic activity is discussed in relation to a recent hypothesis concerning the conformation of acetylcholine required for interaction with nicotinic receptors.5. The compounds tested had no muscarinic activity on the isolated guinea-pig ileum.
Quantification of Drug-Induced mRNA in Human Whole Blood <i>ex vivo</i> (2008)

Apoptosis was induced in heparinized human whole blood by 3 different ways (radiation, bleomycin, or etoposide), and various mRNA were quantified using the method we reported (Clin. Chem. 2006; 52:634-642). We found that cyclin-dependent kinase inhibitor 1A (p21) and p53 upregulated modulator of apoptosis (PUMA) were the most sensitive and universal mRNA markers of apoptosis in leukocytes. In order to define positive and negative responses, a synthetic RNA was spiked into the lysis buffer and the fold increase was calculated. As a result, 837/880 (95.1%) of data points stayed between 0.75 and 1.5 fold increase, and 874/880 (99.3%) were within 0.5-2.0 fold increase. When blood samples from 40 healthy adults were stimulated with 22 different drugs, more than 75% of the samples responded to bleomycin (1 μM), idarubicin (2 μM), vincristine (1 μM), daunorubicin (2 μM), cytarabine (10 μM), to induce p21 and/or PUMA mRNA, and approximately 25% showed no induction. Significant correlation was found between p21 and PUMA mRNA responses, and between daunorubicin and cytarabine, idarubicin, and vincristine for both p21 and PUMA. The quantification of drug-induced mRNA in whole blood will be considered as ex vivo, and is a suitable platform for biomarker screening as well as a model system for drug sensitivity tests in future.
Ultra low-power monolithically integrated capacitive pressure sensor for tire pressure monitoring (2006)

Tire pressure monitoring systems (TPMS) are gaining importance due to improved security standards in the automotive industry. In active systems, the power consumption of the system is of utmost importance for a required lifetime of more than 10 years. The presented integrated circuit comprises high resolution pressure, temperature and voltage monitoring, low-power oscillators, a specialized DSP with RAM/ROM and an EEPROM to store calibration data. The continuously running low-power oscillator for internal wake-up timing is operated with 30 nA. Due to the extremely low-power consumption of all circuit blocks, pressure measurements can be carried out in short intervals (0.5 s). This enables the implementation of a new intelligent dynamic wake-up algorithm to optimize the power-intensive HF-transmission intervals under different driving situations. Thus additional rotation detectors are not needed any more. The charge consumption without HF-transmission results in 48 mAh in 10 years.
From Modeling to Implementation of Virtual Sensors in Body Sensor Networks (2011)

Body Sensor Networks (BSNs) represent an emerging technology which has received much attention recently due to its enormous potential to enable remote, real-time, continuous and non-invasive monitoring of people in health-care, entertainment, fitness, sport, social interaction. Signal processing for BSNs usually comprises of multiple levels of data abstraction, from raw sensor data to data calculated from processing steps such as feature extraction and classification. This paper presents a multi-layer task model based on the concept of Virtual Sensors to improve architecture modularity and design reusability. Virtual Sensors are abstractions of components of BSN systems that include sensor sampling and processing tasks and provide data upon external requests. The Virtual Sensor model implementation relies on SPINE2, an open source domain-specific framework that is designed to support distributed sensing operations and signal processing for wireless sensor networks and enables code reusability, efficiency, and application interoperability. The proposed model is applied in the context of gait analysis through wearable sensors. A gait analysis system is developed according to a SPINE2-based Virtual Sensor architecture and experimentally evaluated. Obtained results confirm that great effectiveness can be achieved in designing and implementing BSN applications through the Virtual Sensor approach while maintaining high efficiency and accuracy.
Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation (2005)

Aspergillus and cytomegalovirus are major causes of morbidity/mortality after haploidentical hematopoietic transplantation. The high degree of mismatching makes cell immunotherapy impossible as it would result in lethal graft-versus-host disease (GvHD). We generated large numbers of donor T-cell clones specific for Aspergillus or cytomegalovirus antigens. We identified clones potentially responsible for causing GvHD by screening them for cross-reactivity against recipient mononuclear cells. Non-recipient reactive, pathogen-specific clones were infused soon after transplantation. They were CD4+ and produced high levels of interferon-gamma and low levels of interleukin-10. In 46 control transplant recipients who did not receive adoptive therapy, spontaneous pathogen-specific T cells occurred in low frequency 9 to 12 months after transplantation and displayed a non-protective low interferon-gamma/high interleukin-10 production phenotype. In the 35 recipients who received adoptive therapy, one single infusion of donor alloantigen-deleted, pathogen-specific clones in the dose range of 10(5) to 10(6) cells/kg body weight did not cause GvHD and induced high-frequency T-cell responses to pathogens, which exhibited a protective high interferon-gamma/low interleukin-10 production phenotype within 3 weeks of infusion. Frequencies of pathogen-specific T cells remained stable over time, and were associated with control of Aspergillus and cytomegalovirus antigenemia and infectious mortality. This study opens new perspectives for reducing infectious mortality after haploidentical transplantations.
An Improved Control Strategy of Limiting the DC-Link Voltage Fluctuation for a Doubly Fed Induction Wind Generator (2008)

The paper presents to develop a new control strategy of limiting the dc-link voltage fluctuation for a back-to-back pulsewidth modulation converter in a doubly fed induction generator (DFIG) for wind turbine systems. The reasons of dc-link voltage fluctuation are analyzed. An improved control strategy with the instantaneous rotor power feedback is proposed to limit the fluctuation range of the dc-link voltage. An experimental rig is set up to valid the proposed strategy, and the dynamic performances of the DFIG are compared with the traditional control method under a constant grid voltage. Furthermore, the capabilities of keeping the dc-link voltage stable are also compared in the ride-through control of DFIG during a three-phase grid fault, by using a developed 2 MW DFIG wind power system model. Both the experimental and simulation results have shown that the proposed control strategy is more effective, and the fluctuation of the dc-link voltage may be successfully limited in a small range under a constant grid voltage and a non-serious grid voltage dip.
Water-Soluble Vitamin D in Human Milk: A Myth (1982)

For the past 50 years, repeated analyses of human milk have shown an average of 20 IU/liter of vitamin D activity. Following the 1977 report of Lakdawala and Widdowson,1 which found that a large amount of water-soluble vitamin D sulfate was present in the whey (or water-soluble) fraction of human milk, the previous studies appeared to be in question. This study by Lakdawala and Widdowson reportedly confirmed earlier reports from Japan2-4 and France5 which not only demonstrated large quantities of vitamin D sulfate in human milk, but also strongly suggested that this vitamin D metabolite had biologic activity in rats.
Minority carrier lifetime in mid-wavelength infrared InAs/InAsSb superlattices: Photon recycling and the role of radiative and Shockley-Read-Hall recombination mechanisms (2014)

The influence of radiative recombination on the minority carrier lifetime in mid-wavelength InAs/InAsSb superlattices was investigated. From the lifetime's dependence on temperature, photon recycling, and carrier concentration, it was demonstrated that radiative lifetime dominates for carrier concentrations &gt;5 × 1014 cm−3, and Shockley-Read-Hall recombination starts to dominate the minority carrier lifetime for carrier concentrations &lt;5 × 1014 cm−3. An observed increase of the minority carrier lifetime with increasing superlattice thickness was attributed to photon recycling, and good agreement between measured and theoretical values of the photon recycling factor was obtained.
A surface micromachined capacitive pressure sensor for biomedical applications (2002)

Rochester Institute of Technology (RIT) and The Department of Pediatric Cardiology, at Strong Memorial Hospital, have joined efforts to work on a research project funded by National Institute of Health (NIH). The goal of this research project was to design and develop a semiconductor pressure sensor, sensitive to small pressure changes within an embryonic chicken heart. A capacitive pressure sensor design was chosen and fabricated to replace the complicated electronics currently being used for pressure measurements in these fetal heart research studies. In addition to the fabrication of the mechanical sensor, an electronic circuit was developed which provided amplification of the capacitance measurement, as well as converting the pressure varying capacitance to a frequency modulated signal. Although a fully integrated chip has not been successfully completed, data has been collected that shows a frequency response verses pressure.