gebhart/patrepeval huggingface dataset:
Detection of Plasmodium falciparum Infection with the Fluorescent Dye, Benzothiocarboxypurine (1991)

The fluorescent dye benzothiocarboxypurine (BCP) intensely stains nucleic acids. The dye does not penetrate viable white blood cells but does stain these cells following fixation. It has also been found that the dye stains the nucleic acid of viable Plasmodium falciparum. We have subsequently evaluated the staining of P. falciparum by benzothiocarboxypurine within red blood cells and have found that the red blood cell membrane is freely permeable to this dye and consequently P. falciparum is stained within the red blood cell. This finding prompted an in-depth analysis of the dye in the laboratory and in a field study as an alternative to Giemsa-stained blood smears and as a means of enhancing the microscopic diagnosis of malarial infection. In a field study the BCP dye allowed detection of malaria in fresh blood at a level equivalent to the Giemsa method (parasitemia ranged from 0.01% to 30%). The BCP staining procedure could also be used with fixed specimens although the differential staining characteristics were lost following specimen preparation. Of 111 blinded samples obtained in the field 22 were negative by Giemsa-stained thin smear, 16 were negative on thick smear and the same 16 were negative by BCP analysis. We have found that the BCP dye offers many advantages compared with the microscopic diagnosis of P. falciparum infection with standard Giemsa stains. These advantages are especially evident in conditions of low parasitemia, in the speed of staining and evaluation, and the relatively low level of training required to provide consistent results.
Robust, sensor-independent target detection and recognition based on computational models of human vision (1998)

Most current artificial vision systems lack robustness and are applicable only to a narrow range of tasks. Crevier (1997) has suggested that this is due to their reliance on a small number of vision mechanisms and to lack of knowledge about how vision algorithms should be integrated. We suggest a systems approach to artificial vision based on computational vision research. The capabilities of biological vision systems are contrasted with those of current piecemeal approaches to artificial vision. A mature, comprehensive vision system, called the Georgia Tech Vision (GTV) simulation is described. GTV incorporates quasilinear filter mechanisms to simulate the processing performed by simple and complex cortical cells. The outputs of these mechanisms are adaptively combined to discriminate targets from clutter and/or one another. GTV outputs predictions of human search and detection performance and/or targeting metrics for automatic target recognition (ATR) applications. Studies validating GTV as a model of human search and detection performance and demonstrating its performance as an ATR are presented.
Intraindividual comparison of higher-order aberrations after implantation of aspherical and spherical intraocular lenses as a function of pupil diameter (2006)

In comparison to a spherical IOL, the aspherical Tecnis IOL reduced Z(4)(0) and 4th-order RMS significantly for pupil diameters of 3 to 6 mm, whereas total HOA RMS was only significantly reduced for a pupil diameter of 6 mm.
A Multi-component CNN-RNN Approach for Dimensional Emotion Recognition in-the-wild (2018)

This paper presents our approach to the One-Minute Gradual-Emotion Recognition (OMG-Emotion) Challenge, focusing on dimensional emotion recognition through visual analysis of the provided emotion videos. The approach is based on a Convolutional and Recurrent (CNN-RNN) deep neural architecture we have developed for the relevant large AffWild Emotion Database. We extended and adapted this architecture, by letting a combination of multiple features generated in the CNN component be explored by RNN subnets. Our target has been to obtain best performance on the OMG-Emotion visual validation data set, while learning the respective visual training data set. Extended experimentation has led to best architectures for the estimation of the values of the valence and arousal emotion dimensions over these data sets.
A Slit Scanning Depth of Route Panorama from Stationary Blur (2005)

This work achieves an efficient acquisition of scenes and their depths along streets. During the movement of a vehicle, a slit in the camera frame is set properly to sample scenes continuously for a route panorama. This paper proposes a novel method of depth estimation by analyzing a new phenomenon named stationary blur in the route panorama. We find its relation with the depth and evaluate its degree at local and global levels. The depth estimation through filtering avoids feature matching and tracking that are error-prone in the scanning of real and complex street scenes. Our method provides reliable results but requires much less data than that of the structure from motion. This keeps the elegance of the route panorama in data representation, and is suitable for real time sensor development. Utilizing the completeness of the route panorama in the scene archiving, we can generate planar models of streets, which can be used in city visualization.
Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells. (1994)

The protein kinase inhibitor 2-aminopurine induces checkpoint override and mitotic exit in BHK cells which have been arrested in mitosis by inhibitors of microtubule function (Andreassen, P. R., and R. L. Margolis. 1991. J. Cell Sci. 100:299-310). Mitotic exit is monitored by loss of MPM-2 antigen, by the reformation of nuclei, and by the extinction of p34cdc2-dependent H1 kinase activity. 2-AP-induced inactivation of p34cdc2 and mitotic exit depend on the assembly state of microtubules. During mitotic arrest generated by the microtubule assembly inhibitor nocodazole, the rate of mitotic exit induced by 2-AP decreases proportionally with increasing nocodazole concentrations. At nocodazole concentrations of 0.12 microgram/ml or greater, 2-AP induces no apparent exit through 75 min of treatment. In contrast, 2-AP brings about a rapid exit (t1/2 = 20 min) from mitotic arrest by taxol, a drug which causes inappropriate overassembly of microtubules. In control mitotic cells, p34cdc2 localizes to kinetochores, centrosomes, and spindle microtubules. We find that efficient exit from mitosis occurs under conditions where p34cdc2 remains associated with centrosomal microtubules, suggesting it must be present on these microtubules in order to be inactivated. Mitotic slippage, the natural reentry of cells into G1 during prolonged mitotic block, is also microtubule dependent. At high nocodazole concentrations slippage is prevented and mitotic arrest approaches 100%. We conclude that essential components of the machinery for exit from mitosis are present on the mitotic spindle, and that normal mitotic exit thereby may be regulated by the microtubule assembly state.
Ultrasonic computed tomography based on full-waveform inversion for bone quantitative imaging (2017)

We introduce an ultrasonic quantitative imaging method for long bones based on full-waveform inversion. The cost function is defined as the difference in the L <sup>2</sup>-norm sense between observed data and synthetic results at a given iteration of the iterative inversion process. For simplicity, and in order to reduce the computational cost, we use a two-dimensional acoustic approximation. The inverse problem is solved iteratively based on a quasi-Newton technique called the Limited-memory Broyden-Fletcher-Goldfarb-Shanno method. We show how the technique can be made to work fine for benchmark models consisting of a single cylinder, and then five cylinders, the latter case including significant multiple diffraction effects. We then show pictures obtained for a tibia-fibula bone pair model. Convergence is fast, typically in 15 to 30 iterations in practice in each frequency band used. We discuss the so-called 'cycle skipping' effect that can occur in such full waveform inversion techniques and make them remain trapped in a local minimum of the cost function. We illustrate strategies that can be used in practice to avoid this. Future work should include viscoelastic materials rather than acoustic, and real data instead of synthetic data.
Response to ‘‘Comment on ‘Nonlinear optical and electro-optical properties of single crystal CsTiOAsO4’ ’’ [Appl. Phys. Lett. 64, 2457 (1994)] (1994)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation L. T. Cheng, L. K. Cheng, J. D. Bierlein, F. C. Zumsteg; Response to ‘‘Comment on ‘Nonlinear optical and electro‐optical properties of single crystal CsTiOAsO4’ ’’ [Appl. Phys. Lett. 64, 2457 (1994)]. Appl. Phys. Lett. 2 May 1994; 64 (18): 2458. https://doi.org/10.1063/1.111599 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Air Film Dynamics for Micro-Textured Flying Head Slider Bearings in Magnetic Hard Disk Drives (2002)

This paper describes the air film dynamics for micro-textured flying head slider bearings in magnetic hard disk drives and it discusses their ability to increase the air film damping. In order to study the effects of micro-textures on air film dynamic characteristics of flying head slider bearings, two-dimensional micro-textures are modeled as deterministic rectangular models in the transverse and longitudinal directions. Dynamic analysis of these micro-textured flying head slider bearings is carried out by computing the impulse responses of the sliders and applying the modal analysis method to obtain their modal frequencies, damping ratios, and mode shapes. It is found that micro-textures on air bearing surfaces in the transverse direction have very significant effects and increase the air film damping of the slider’s three vibration modes but do not affect the air film stiffness. The same is not true for micro-texture in the longitudinal direction. The effects of transverse micro-textures’ spacing and depth on the air film dynamics are also numerically investigated in detail. The optimum values for high air film damping ratios are obtained. It is found that transverse micro-textures having small spacing are not very effective, being equivalent to the surface roughness effect.
A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria (2002)

We have identified a novel c-Jun N-terminal kinase (JNK)-interacting protein, Sab, by yeast two-hybrid screening. Sab binds to and serves as a substrate for JNK in vitro, and was previously found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk). Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine—proline JNK phosphorylation sites in the C-terminal half of the molecule. Using deletion and site-directed mutagenesis, we demonstrate that the most N-terminal KIM in Sab is essential for JNK binding, and that, as with c-Jun, physical interaction with JNK is necessary for Sab phosphorylation. Interestingly, confocal immunocytochemistry and cell fractionation studies indicate that Sab is associated with mitochondria, where it co-localizes with a fraction of active JNK. These and previously reported properties of Sab suggest a possible role in targeting JNK to this subcellular compartment and/or mediating cross-talk between the Btk and JNK signal transduction pathways.
3GPP LTE Release 9 and 10 requirement analysis to physical layer UE testing (2013)

The purpose of this thesis was to analyze the testing requirements to physical layer features which are used in LTE Release 9 and 10 timeframe. The aim of the analysis was to define test case requirements for new features from the physical layer point of view. This analysis can then be utilized to implement and design test cases using commercial eNB simulators. The analysis was carried out by studying the 3GPP specifications and by investigating the integration and system level testing requirements. Different feature specific parameters were evaluated and different testing aspects were studied in order to verify the functionalities and performance of the UE. Also, different conformance test case scenarios and field testing aspects were investigated in order to improve the test case planning in the integration and system testing phase.\n\nThe analysis showed that in Rel-9 there are two main features which have a great impact on the Rel-9 physical layer testing. These two features are the dual-layer beamforming and UE positioning which is done with OTDOA and E-CID methods. It was analyzed that the requirements for the downlink dual-layer beamforming focus on TDD side and the test plan must contain especially throughput performance testing in integration and system phase testing. OTDOA and E-CID methods, on the other hand, need test plans which are concentrating on the positioning accuracy.\n\nIn Rel-10, the analysis showed that there are plenty of new features on physical layer to ensure the transition from LTE to LTE-Advanced. The main requirements were assigned for the CA feature which has testing activities especially on the UE feedback operations. Also, different kinds of CA deployment scenarios were analyzed to evaluate more closely the initial CA testing scenarios in integration and system testing. Analysis continued with downlink multi-layer beamforming where the requirements were seen to concentrate on new CSI-RS aspects and to throughput performance testing. Uplink MIMO aspects were analyzed at the end and the studies showed that this feature may have a minor role in Rel-10 timeframe and therefore it does not have any important testing requirements which should be taken into account in test plans.
An Approach for Specification-based Test Case Generation for Web Services (2007)

Web services applications are built by the integration of many loosely coupled and reusable services using open standards. Testing Web service is important in detecting faults and assessing quality attributes. A difficulty in testing Web services applications is the unavailability of the source code for both the application builder and the broker. This paper propose a solution to this problem by providing a formal, specification-based approach for automatically generating test cases for web services based on the WSDL input messages parts' XML Schema datatypes. Examples of using this approach are then given in order to give evidence of its usefulness. The role of the application builders and the brokers in using this approach to test Web services is also described.
Efficient Universal Computing Architectures for Decoding Neural Activity (2012)

The ability to decode neural activity into meaningful control signals for prosthetic devices is critical to the development of clinically useful brain- machine interfaces (BMIs). Such systems require input from tens to hundreds of brain-implanted recording electrodes in order to deliver robust and accurate performance; in serving that primary function they should also minimize power dissipation in order to avoid damaging neural tissue; and they should transmit data wirelessly in order to minimize the risk of infection associated with chronic, transcutaneous implants. Electronic architectures for brain- machine interfaces must therefore minimize size and power consumption, while maximizing the ability to compress data to be transmitted over limited-bandwidth wireless channels. Here we present a system of extremely low computational complexity, designed for real-time decoding of neural signals, and suited for highly scalable implantable systems. Our programmable architecture is an explicit implementation of a universal computing machine emulating the dynamics of a network of integrate-and-fire neurons; it requires no arithmetic operations except for counting, and decodes neural signals using only computationally inexpensive logic operations. The simplicity of this architecture does not compromise its ability to compress raw neural data by factors greater than [Formula: see text]. We describe a set of decoding algorithms based on this computational architecture, one designed to operate within an implanted system, minimizing its power consumption and data transmission bandwidth; and a complementary set of algorithms for learning, programming the decoder, and postprocessing the decoded output, designed to operate in an external, nonimplanted unit. The implementation of the implantable portion is estimated to require fewer than 5000 operations per second. A proof-of-concept, 32-channel field-programmable gate array (FPGA) implementation of this portion is consequently energy efficient. We validate the performance of our overall system by decoding electrophysiologic data from a behaving rodent.
Interfacing Engineered Nanoparticles with Biological Systems: Anticipating Adverse Nano–Bio Interactions (2012)

The innovative use of engineered nanomaterials in medicine, be it in therapy or diagnosis, is growing dramatically. This is motivated by the current extraordinary control over the synthesis of complex nanomaterials with a variety of biological functions (e.g. contrast agents, drug-delivery systems, transducers, amplifiers, etc.). Engineered nanomaterials are found in the bio-context with a variety of applications in fields such as sensing, imaging, therapy or diagnosis. As the degree of control to fabricate customized novel and/or enhanced nanomaterials evolves, often new applications, devices with enhanced performance or unprecedented sensing limits can be achieved. Of course, interfacing any novel material with biological systems has to be critically analyzed as many undesirable adverse effects can be triggered (e.g. toxicity, allergy, genotoxicity, etc.) and/or the performance of the nanomaterial can be compromised due to the unexpected phenomena in physiological environments (e.g. corrosion, aggregation, unspecific absorption of biomolecules, etc.). Despite the need for standard protocols for assessing the toxicity and bio-performance of each new functional nanomaterial, these are still scarce or currently under development. Nonetheless, nanotoxicology and relating adverse effects to the physico-chemical properties of nanomaterials are emerging areas of the utmost importance which have to be continuously revisited as any new material emerges. This review highlights recent progress concerning the interaction of nanomaterials with biological systems and following adverse effects.
Role of topical and nutritional supplement to modify the oxidative stress<sup>*</sup> (2002)

From the obtained data, it seems possible to conclude that all the compounds used play interesting role as topical and systemic photoprotectants, thanks to their interesting antioxidant property. Moreover, the antioxidant treatment seems to be a promising therapeutic approach also in reducing the oxidative stress of people affected by photoaging.
K562 human erythroleukemia cells demonstrate commitment (1985)

Commitment, ie, the decision to express a differentiated phenotype and to terminate proliferation irreversibly in the absence of inducer, was investigated in K562 human erythroleukemia cells. Cells were cultured for 0, 1, 2, 3, or 4 days with inducer and then plated in medium containing methylcellulose without inducer. Daily after plating, hemoglobin content was scored by benzidine staining, and growth was assessed by estimating the cell number per colony. With all inducers used, three types of colonies were found, those containing only benzidine-positive cells, those containing only benzidine-negative cells, and those containing both cell types (mixed colonies). Thymidine produced a progressive increase in the percentage of positive and mixed colonies and a progressive fall in the percentage of negative colonies. Whereas negative colonies grew at an exponential rate with a generation time of about 20 hours, positive colonies reached an average maximum size of 16 cells, representing a total of four divisions. Butyrate had a similar effect, except that the rise was greater for mixed colonies than for positive colonies, and the plateau in positive colony size was less evident. In contrast, CO2 depletion or hemin treatment induced an increase in the fraction of cells staining benzidine positive that was lost rapidly upon removal of the inducing condition. Thus, of the four conditions, thymidine and butyrate caused commitment, whereas hemin and CO2 depletion did not. Thus K562 cells, like Friend cells, demonstrate commitment, but, unlike Friend cells, demonstrate a significant rate of commitment in the absence of inducer and hence form a significant percentage of mixed colonies with or without inducer.
Implementation of reconfigurable transceiver based on digital IF for multiple wideband CDMA signals (2004)

In this paper, we have presented the improved IF transceiver architecture and its implementation results on re-configurable transceiver based on digital IF for multiple wideband CDMA base stations, which have been implemented as ADC, DAC with high speed and resolution and high performance FPGA. The implemented digital IF transceiver has been designed to support multiple frequency allocations and multiple standards by only modifying the programmable software not its hardware as the software defined radio concept. The digital complex quadrature modulation technique has been used for the digital IF transmitter, which is able to combine multiple frequency bands in digital processing block not RF block and to reject the image frequency signals. Also, this method is possible to apply to the baseband digital adaptive predistortion technique. And, the bandpass sampling technique has been used for the digital IF receiver to reduce the sampling rate of ADC. As the implementation results, the FIR and interpolation/decimation halfband filters over 200 taps, digital mixers and digital synthesizers has been implemented on FPGA with 200 million gates for the digital IF transceivers in wideband CDMA base stations. This paper has presented the experiment results on the frequency response and constellation of the implemented digital IF transceiver through back-to-back combining a transmitter with a receiver using a simplified 16QAM physical channel model.