gebhart/patrepeval huggingface dataset:
Extending the closed-form image source model for source directivity (Digital appendix) (2018)

The image source model (ISM) is a widespread tool in geometrical room acoustic simulation for the generation of early reflections, which can take into account the source and receiver directivity, as well as the absorption properties of the acoustic environment. A downside of the ISM is the increase in computational effort with increasing image source order caused by costly visibility checks that need to be done separately for each image source. In the special case of a shoebox-shaped, rectangular room, a closed-form ISM exists, thus eliminating the need for visibility checks. However, the closed-form ISM inherently assumes omnidirectional sources, an assumption that is violated in almost all real-life scenarios. In the current study, the closed-form ISM is extended for the source directivity by exploiting geometrical properties of the room. Examples for naturally sounding auralizations from a closed-form ISM combined with a stochastic model for the late reflections are given in the digital appendix, thus making this an appealing approach for applications that require perceptually plausible and computationally efficient simulations rather than high physical accuracy.
Altered cytoskeleton in smooth muscle of aganglionic bowel. (2002)

This study demonstrates that the cytoskeletal proteins are abundant in the smooth muscle of normal bowel, but are absent or markedly reduced in the aganglionic bowel of HD. As cytoskeletal proteins are required for the coordinated contraction of muscle cells, their absence may be responsible for the motility dysfunction in the aganglionic segment.
(<i>R</i>)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase (1999)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase KinaseThomas D. Aicher, Robert C. Anderson, Gregory R. Bebernitz, Gary M. Coppola, Charles F. Jewell, Douglas C. Knorr, Charles Liu, Donald M. Sperbeck, Leonard J. Brand, Robert J. Strohschein, Jiaping Gao, Christine C. Vinluan, Suraj S. Shetty, Carol Dragland, Emma L. Kaplan, Dominick DelGrande, Amin Islam, Xilin Liu, Robert J. Lozito, Wieslawa M. Maniara, R. Erik Walter, and William R. MannView Author Information Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, New Jersey 07901 Cite this: J. Med. Chem. 1999, 42, 15, 2741–2746Publication Date (Web):July 14, 1999Publication History Received25 May 1999Published online14 July 1999Published inissue 1 July 1999https://pubs.acs.org/doi/10.1021/jm9902584https://doi.org/10.1021/jm9902584rapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1315Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Assays,Inhibitors,Peptides and proteins,Post-translational modification Get e-Alerts
Self-organized Fe nanowire arrays prepared by shadow deposition on NaCl(110) templates (1997)

Iron nanowire arrays have been grown by shadow deposition on a self-organized grating template produced by annealing the sodium chloride (110) surface. The typical wire size as measured using transmission electron microscopy is 45 nm×13 nm×10 μm. The typical wire array period is 90 nm. The magnetic properties were dominated by a strong in-plane shape anisotropy. The hysteresis loops examined by magneto-optical Kerr effect measurements indicated coherent switching, even though the individual wires were isolated from one another.
Nonviral transfection of human umbilical cord blood dendritic cells is feasible, but the yield of dendritic cells with transgene expression limits the application of this method in cancer immunotherapy. (2006)

Dendritic cells (DC) generated from human umbilical cord blood might replace patients' DC in attempts to elicit tumor-specific immune response in cancer patients. We studied the efficiency of transfection of human cord blood DC with plasmid DNA carrying the enhanced version of green fluorescent protein (EGFP) as a reporter gene, to test if nonviral gene transfer would be a method to load DC with protein antigens for immunotherapy purposes. Cord blood mononuclear cells were cultured in serum-free medium in the presence of granulocyte-monocyte colony stimulating factor (GM-CSF), stem cell factor (SCF) and Flt-3 ligand (FL), to generate DC from their precursors, and thereafter transfected by electroporation. Maturation of DC was induced by stimulation with GM-CSF, SCF, FL and phorbol myristate acetate (PMA). Transfected DC strongly expressed EGFP, but transfection efficiency of DC, defined as HLA-DR(+) cells lacking lineage-specific markers, did not exceed 2.5%. Expression of the reporter gene was also demonstrated in the DC generated from transfected, purified CD34(+) cord blood cells, by stimulation with GM-CSF, SCF, FL, and tumor necrosis factor alpha (TNF-alpha). Transfection of CD34(+) cells was very efficient, but proliferation of the transfected cells was much reduced as compared to the untransfected cells. Therefore, the yield of transgene-expressing DC was relatively low. In conclusion, nonviral transfection of cord blood DC proved feasible, but considering the requirements for immunotherapy in cancer patients, transfection of differentiated DC or generation of DC from transfected hematopoietic stem cells provide only a limited number of DC expressing the transgene.
Suppression of HBsAg Production in PLC/PRF/5 Human Hepatoma Cell Line by Interferons (1988)

Recombinant human interferon alpha 2a as well as natural human interferons alpha and beta significantly suppressed the production of hepatitis B surface antigen by PLC/PRF/5 cells (which have been established from a human primary hepatocellular carcinoma and proven to carry the hepatitis B virus DNA) and inhibited proliferation of these cells in vitro. However, the production of alpha-fetoprotein by PLC/PRF/5 cells was less significantly affected by any of the interferons. These results suggest that these interferons not only suppress cellular proliferation but also selectively inhibit the action of the HBV gene which is persistently present in these cells.
Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice (2012)

Consumption of hydrogen-rich water may be an effective treatment for NASH by reducing hepatic oxidative stress, apoptosis, inflammation, and hepatocarcinogenesis.
Dragonfly+: Low Cost Topology for Scaling Datacenters (2017)

Dragonfly topology was introduced by Kim et al. [1] aiming to decrease the cost and diameter of the network. The topology divides routers into groups connected by long links. Each group strives to implement high-radix virtual router, connected by a completely-connected topology. In this paper, we propose an extended Dragonfly+ network in which routers inside the group are connected in Clos-like topology. Dragonfly+ is superior to conventional Dragonfly due to the significantly larger number of hosts which it is able to support. In addition, Dragonfly+ supports similar or better bi-sectional bandwidth for various traffic patterns, and requires smaller number of buffers to avoid credit loop deadlocks in lossless networks. Moreover, we introduce a novel Fully Progressive Adaptive Routing algorithm with remote congestion notifications. To support our proposal we present analytical analysis and simulations.
Collagen-gentamicin implant for prevention of sternal wound infection; long-term follow-up of effectiveness (2009)

In a previous randomized controlled trial (LOGIP trial) the addition of local collagen-gentamicin reduced the incidence of postoperative sternal wound infections (SWI) compared with intravenous prophylaxis only. Consequently, the technique with local gentamicin was introduced in clinical routine at the two participating centers. The aim of the present study was to re-evaluate the technique regarding the prophylactic effect against SWI and to detect potential shifts in causative microbiological agents over time. All patients in this prospective two-center study received prophylaxis with application of two collagen-gentamicin sponges between the sternal halves in addition to routine intravenous antibiotics. All patients were followed for 60 days postoperatively. From January 2007 to May 2008, 1359 patients were included. The 60-day incidences of any SWI was 3.7% and of deep SWI 1.5% (1.0% mediastinitis). Both superficial and deep SWI were significantly reduced compared with the previous control group (OR=0.34 for deep SWI, P<0.001). There was no increase in the absolute incidence of aminoglycoside resistant agents. The majority of SWI were caused by coagulase-negative staphylococci (CoNS). The incidence of deep SWI caused by Staphylococcus aureus was 0.07%. The results indicate a maintained effect of the prophylaxis over time without absolute increase in aminoglycoside resistance. (ClinicalTrials.gov NCT00484055).
Walking human avoidance and detection from a mobile robot using 3D depth flow (2002)

This paper shows walking human avoidance and detection behavior of a mobile robot using the 3D depth flow. The 3D depth flow proposed is able to measure the 3D motion vector of every pixels between two time sequential images. First, a definition of the 3D depth flow and a simple 3D depth flow calculation method are presented. Then an implementation of the real-time 3D depth flow generation system using a standard PC is described, and the experimental results are given. Finally, as an application, the walking human detection and avoidance task using a mobile robot in real environments is shown.
Does the Metabolic Syndrome Exist? (2006)

of cholesterol-lowering with simvastatin in 5,963 people with diabetes: a random-ised placebo-controlled trial. Lancet 361:
Physics-motivated features for distinguishing photographic images and computer graphics (2005)

The increasing photorealism for computer graphics has made computer graphics a convincing form of image forgery. Therefore, classifying photographic images and photorealistic computer graphics has become an important problem for image forgery detection. In this paper, we propose a new geometry-based image model, motivated by the physical image generation process, to tackle the above-mentioned problem. The proposed model reveals certain physical differences between the two image categories, such as the gamma correction in photographic images and the sharp structures in computer graphics. For the problem of image forgery detection, we propose two levels of image authenticity definition, i.e., imaging-process authenticity and scene authenticity, and analyze our technique against these definitions. Such definition is important for making the concept of image authenticity computable. Apart from offering physical insights, our technique with a classification accuracy of 83.5% outperforms those in the prior work, i.e., wavelet features at 80.3% and cartoon features at 71.0%. We also consider a recapturing attack scenario and propose a counter-attack measure. In addition, we constructed a publicly available benchmark dataset with images of diverse content and computer graphics of high photorealism.
Very short-term load forecasting using artificial neural networks (2000)

In a deregulated, competitive power market, utilities tend to maintain their generation reserve close to the minimum required by an independent system operator. This creates a need for an accurate instantaneous-load forecast for the next several dozen minutes. This paper presents a novel approach to very short-time load forecasting by the application of artificial neural networks to model load dynamics. The proposed algorithm is more robust as compared to the traditional approach when actual loads are forecasted and used as input variables. It provides more reliable forecasts, especially when the weather conditions are different from those represented in the training data. The proposed method has been successfully implemented and used for online load forecasting in a power utility in the United States. To assure robust performance and training times acceptable for online use, the forecasting system was implemented as a set of parsimoniously designed neural networks. Each network was assigned a task of forecasting load for a particular time lead and for a certain period of day with a unique pattern in load dynamics. Some details of this are presented in the paper.
Preparation and Electrical Properties of Some Thiospinels (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Electrical Properties of Some ThiospinelsR. J. Bouchard, P. A. Russo, and A. WoldCite this: Inorg. Chem. 1965, 4, 5, 685–688Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/ic50027a019https://doi.org/10.1021/ic50027a019research-articleACS PublicationsRequest reuse permissionsArticle Views833Altmetric-Citations194LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improved spatial sampling of ECG potentials on the body surface by repositioning electrodes from the standard 12-lead ECG (2002)

We propose a simple, practical approach to increase the diagnostic information content of the standard 12-lead ECG by repositioning selected chest leads. We used a set of 746 120-lead body-surface potential maps (BSPMs). Coefficients to reconstruct all BSPM leads from the standard ECG were derived by linear regression. Similarly, BSPMs were reconstructed when two of the leads V3-V6 were replaced by electrodes at other positions on the anterior part of the thorax. Repositioning lead V4 at two intercostal spaces below V2 and lead V6 at two intercostal spaces above V2 or at three intercostal spaces above V4 showed increased reconstruction performance as compared with the standard electrode positions in most parts of the anterior thorax, including regions that are known to contain important diagnostic information that is less well represented by the standard ECG. Also, this approach obviates the need to determine the precise location of V4, which may be difficult in women.
Plasma tau in Alzheimer disease (2016)

Plasma tau partly reflects AD pathology, but the overlap between normal aging and AD is large, especially in patients without dementia. Despite group-level differences, these results do not support plasma tau as an AD biomarker in individual people. Future studies may test longitudinal plasma tau measurements in AD.
Non-conductive film and compression molding technology for self-assembly-based 3D integration (2012)

Two key technologies consisting of chip-to-wafer bonding through a non-conductive film (NCF) and wafer-level packaging using compression molding were studied for self-assembly-based 3D integration, especially reconfigured wafer-to-wafer stacking. 4-mm-by-5-mm chips having 20-μm-pitch Cu-SnAg microbumps were successfully bonded to wafers through NCF. The resulting daisy chain obtained from the chip-to-wafer structure showed low contact resistance of approximately 50 MΩ/bump. Compression molding was implemented to a chip-on-wafer structure. Grinding of the chip-on-wafer structure gave low total thickness variation (TTV) within 1 μm and the following CMP led good planarization capability.
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome (1999)

Papillon-Lefèvre syndrome (PLS) is an autosomal recessive disorder characterised by palmoplantar hyperkeratosis and severe early onset periodontitis that results in the premature loss of the primary and secondary dentitions. A major gene locus for PLS has been mapped to a 2.8 cM interval on chromosome 11q14. Correlation of physical and genetic maps of this interval indicate it includes at least 40 ESTs and six known genes including the lysosomal protease cathepsin C gene (CTSC). The CTSC message is expressed at high levels in a variety of immune cells including polymorphonuclear leucocytes, macrophages, and their precursors. By RT-PCR, we found CTSC is also expressed in epithelial regions commonly affected by PLS, including the palms, soles, knees, and oral keratinised gingiva. The 4.7 kb CTSC gene consists of two exons. Sequence analysis of CTSC from subjects affected with PLS from five consanguineous Turkish families identified four different mutations. An exon 1 nonsense mutation (856C-->T) introduces a premature stop codon at amino acid 286. Three exon 2 mutations were identified, including a single nucleotide deletion (2692delA) of codon 349 introducing a frameshift and premature termination codon, a 2 bp deletion (2673-2674delCT) that results in introduction of a stop codon at amino acid 343, and a G-->A substitution in codon 429 (2931G-->A) introducing a premature termination codon. All PLS patients were homozygous for cathepsin C mutations inherited from a common ancestor. Parents and sibs heterozygous for cathepsin C mutations do not show either the palmoplantar hyperkeratosis or severe early onset periodontitis characteristic of PLS. A more complete understanding of the functional physiology of cathepsin C carries significant implications for understanding normal and abnormal skin development and periodontal disease susceptibility.
Fiber lasers with a tunable green output (2008)

The tuning capabilities at the frequency doubling of the Yb-doped fiber laser using type-II second harmonic generation (SHG) in a KTP crystal in a walk-off compensated geometry are studied. Three configurations for different wavelengths are compared and the best one that provides a continuous tuning in the range 540–560 nm due to crystal tilting is chosen. The intracavity frequency-doubling scheme is applied to increase the efficiency.
Radiofrequency Catheter Ablation Using Long Coiled Electrodes: Impact of Irrigation on Lesion Dimensions and Incidence of Coagulum Formation (2001)

Ablation catheters with multiple long coiled electrodes have been recently developed to induce continuous linear lesions for the treatment of atrial fibrillation. The efficacy and safety of ablation catheters with multiple long coiled electrodes has not been evaluated. The aim of the present in vivo study was to investigate the influence of saline irrigation on lesion dimensions and coagulum formation during RF current ablation using those ablation catheters. In 14 anesthetized sheep, the thigh muscle was prepared as a cradle and filled with heparinized blood (37 degrees C). The quadripolar coiled ablation catheter (electrode length 7 mm, electrode distance 2 mm) was placed parallel to the muscle with standardized 10-g contact pressure. RF current energy was delivered sequentially temperature-(70 degrees C) or power-controlled (10, 20, 30, or 40 W) with additional irrigation of the electrode (10 mL/min normal saline) for 90 seconds. Forty-two of 129 RF current lesions were induced by temperature-controlled and 87 by irrigated ablation. Except for three lesions following low energy irrigated application (10 W), all lesions were continuous. Significantly larger lesions following irrigated RF current applications were produced with a power output of 30 W (depth 0.74 +/- 0.13 cm, width 0.78 +/- 0.13 cm) and 40 W (depth 0.75 +/- 0.16 cm, width 0.92 +/- 0.28 cm) as compared to 20 W (depth 0.47 +/- 0.13 cm, width 0.82 +/- 0.22 cm). Coagulum formation adherent to the electrode was exclusively observed following 18 of 42 nonirrigated RF current ablations. In conclusion, irrigated coiled ablation electrodes induce continuous linear lesions with a power output of 20-40 W. The risk of coagulum formation at the coiled electrode can be avoided by irrigation.
A General Method for the Selection of an Optimum Choke-Management Strategy (2016)

Summary Different choke-management strategies have been adopted by operators in the field; however, no general method exists for systematically selecting an optimum choke-management strategy. In this study, we propose a general method for the selection of bean-up duration and bean-up strategy (choke management) that will maximize well productivity by minimizing formation damage, reducing sand production, and reducing the impact of multiphase-flow effects. Strategies of stepwise bottomhole-pressure (BHP) adjustments are compared by use of the principle of superposition and the analytical solution of the transient radial-diffusion equation for vertical wells operating under different choke settings. The optimum choke-management strategy is based on the anticipated formation-damage mechanisms. For example, if fines migration and sand production are a concern, then minimizing the wellbore pressure gradients is the primary criterion for the selection of the optimum choke-management strategy. Using the analytical solution and simulation results, we conclude that for relatively short bean-up durations (i.e., infinite-acting behavior), the pressure-gradient reduction at the wellbore varies logarithmically with increasing bean-up duration. Choke-management strategies appear to have similar performance as far as no more than 70% of the drawdown is applied during the initial 20% of the overall bean-up duration. For longer durations (i.e., when the presence of the no-flow boundary is felt), the optimum strategy depends on both reservoir properties and radial extent. For the case of square drainage area, a plot suggesting the optimum strategy with respect to dimensionless duration is presented. Positive skin and multiphase flow near the wellbore negatively affect the performance of bean-up strategies. For vertical wells producing from multiple layers, bean-up strategies should be selected with respect to the effective horizontal permeability, ultimately yielding the greatest pressure-gradient reduction in the low-permeability zones. The proposed method enables engineers to select the optimum choke-management strategy with respect to bean-up duration and formation properties. The duration of the bean-up process is drawdown dependent, thus further research is encouraged in determining the maximum allowable pressure gradient to curtail sand production.