gebhart/patrepeval huggingface dataset:
An parallelized deep packet inspection design in software defined network (2014)

Deep packet inspection (DPI) is a key technology in software defined network (SDN) which can centralize network policy control and accelerate packet transmission. In this paper, we propose a new SDN architecture with DPI module. Base on the centralization idea of SDN, we deploying a parallel DPI to the control layer. We present DPI interface in the SDN controller and discuss OpenFlow protocol extension. Paralleling the DPI algorithm effectively reduces the time of detecting packets and sending flow tables. We also describe an Adaptive Highest Random Weight with an additional feedback corresponding to queue length and string length matching at each processor. The original Highest Random Weight (HRW) hash ensures the connection locality. Treating all tasks as the same weight just balances the workload over the number of different task. By adding the adjustment multiplier and combined with the characteristics of the fixed hash function, the system can allocate resource dynamically and achieve connection-level parallelism in consideration of the processing time for per packet.
Flow Binding in Proxy Mobile IPv6 (2010)

This document introduces extensions to Proxy Mobile IPv6 that allows
networks dynamically binding IP flows to different interfaces of a
mobile node.
Uptake and Transport of Paraquat in Slash Pine (1975)

Abstract Uptake and movement of paraquat (1,1'dimethyl-4,4'bipyridylium dichloride) into the transpiration stream of 25-year-old slash pine ( Pinus elliottii Engelm.) trees was followed using methyl- 14 C-paraquat (10µCi/tree) applied in 8 and 3 percent solutions with commercial paraquat. Initial uptake from saturated cellulose pads into xylem was rapid, whereas upward axial movement in outer rings of xylem was 100-fold less than the established velocity of water transport in pines. Velocity of paraquat- 14 C movement was approximately 30 cm/day vertically and 0.5 cm/day radially along negative pressure gradients in xylem. Recovery of 14 C-paraquat by sulphuric acid extraction of xylem samples above the site of application, followed by thin layer chromatography of partially purified extracts, indicated that much radioactivity was still in the form of methyl- 14 C-paraquat. The physiological significance of paraquat's strong affinity for cellulose, resulting in its slow movement both vertically and horizontally, is briefly discussed as it relates to increased oleoresin synthesis and lightwood formation. Forest Sci. 21:359-364.
[Demonstration of a specific receptor site for glucagon-37 (oxyntomodulin/bioactive enteroglucagon) in rat oxyntic glands]. (1984)

In this work, we show directly the existence of specific binding sites for Glucagon-37 (G-37) in isolated oxyntic glands from rat fundic mucosa. The binding of 125I-Glucagon-37 was inhibited by G-37 with a dissociation constant KD = 2.6 X 10(-9) M (high affinity binding capacity = 85 fmol/mg of protein) and by pancreatic Glucagon (G-29) with a KD = 2.2 X 10(-8) M. These results confirm the tissue specificity of G-37, evidenced in vitro on the cyclic AMP production by the same glands and in vivo on the inhibition of gastric acid secretion. They suggest that these activities are related to the G-37-binding on this novel receptor site for Glucagon-related peptides, which is distinct from receptors for the main stimulants of acid secretion, such as Gastrin, Histamine or cholinergic agents.
Trifluoromethyl fluoroformate (1965)

P. J. Aymonino, Chem. Commun. (London), 1965, 241 DOI: 10.1039/C19650000241
Normalization of Plasma Lipid Peroxides, Monocyte Adhesion, and Tumor Necrosis Factor-α Production in NIDDM Patients After Gliclazide Treatment (1998)

Gliclazide administration to NIDDM patients inhibits the increased adhesiveness of diabetic monocytes to endothelial cells and reduces the production of TNF-alpha by these cells. These results suggest that treatment of NIDDM subjects with gliclazide may be beneficial in the prevention of atherosclerosis associated with NIDDM.
Hyperoxia Alters Phorbol Ester-Induced Phospholipase D Activation in Bovine Lung Microvascular Endothelial Cells (2003)

We investigated the effect of hyperoxia on phospholipase D (PLD) activation in bovine lung microvascular endothelial cells (BLMVECs). Generation of intracellular reactive oxygen species in BLMVECs exposed to hyperoxia for 2 or 24 h was three-fold higher compared with normoxic cells as measured by dichlorodihydrofluorescein di(acetoxymethyl ester) fluorescence. Exposure of BLMVECs to hyperoxia for 2 or 24 h attenuated 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated PLD activation compared with normoxic cells, however, hyperoxia did not alter basal PLD activity. Antioxidants, such as propyl gallate and pyrrolidine dithiocarbamate, reversed the effect of hyperoxia on TPA-induced PLD activity. Furthermore, the TPA-induced PLD activation was inhibited not only by the protein kinase C inhibitor, Go6976, but also by the tyrosine kinase inhibitor, genistein, and by the Src kinase specific inhibitor, PP-2, suggesting the involvement of protein kinase C and also tyrosine kinases in TPA-induced PLD activation. Western blot analysis of cell lysates from the hyperoxic (2 or 24 h) BLMVECs stimulated with TPA with anti-phosphotyrosine antibody showed an attenuation in overall tyrosine phosphorylation of proteins. In conclusion, we have demonstrated that hyperoxia enhanced the generation of reactive oxygen species in lung microvascular endothelial cells and attenuated TPA-induced protein tyrosine phosphorylation and PLD activation. As protein tyrosine phosphorylation and PLD play important roles in inflammatory responses, this could provide a mechanism for the regulation of endothelial barrier function during hyperoxic lung injury.
Physical and numerical modeling of drag load development on a model end-bearing pile (2013)

A centrifuge model study is carried out to investigate the behavior of pile subject to negative skin friction induced by pile installation, ground water drawdown and surcharge loading. A single end-bearing pile is examined as the induced negative skin friction would induce the most severe stress on the pile structural material as compared to friction piles. In addition, the behavior of the pile under simultaneous negative skin friction and dead/live loads is examined. To facilitate detailed interpretations of the test results, the model setup is extensively instrumented and involves elaborate test control schemes. To further examine the phenomenon of negative skin friction on an end-bearing pile, finite element analyses were conducted. The numerical analysis is first validated against the centrifuge test data and subsequently extended to examine the effects of pile slenderness ratio, surcharge intensity and pile-soil stiffness ratio on the degree of mobilization of negative skin friction induced on the pile. Finally experimental and numerical studies are conducted to examine the effect of applied transient live load on pile subject to negative skin friction.
Religious Orientation and Pain Management (1997)

Occupational therapists may find pain management less effective than anticipated for the patient's condition. In exploring additional avenues of relief, it is important to look beyond physical agents. The therapist must sort physical, psychological, and spiritual components of pain to provide appropriate intervention or referral. The interface between health care and religion is strongest at the point of confrontation with a life-changing event. Literature addressing the relationship between religious orientation and pain perception differentiates among major religions but not among differences in beliefs of diverse denominational groups. Understanding beliefs about pain may be indispensable to its effective management. Productivity demands necessitate sensitivity to factors other than the physical in order to avoid ineffective treatment. The patient's beliefs can be explored within the contexts of initial evaluation and the course to treatment. Knowledge of the mechanics of pain and treatment modalities can be augmented by awareness of the influence of beliefs on response to treatment.
Combined Photoacoustic and Molecular Fluorescence Imaging In Vivo (2005)

Because of the overwhelming scattering of light in biological tissues, the spatial resolution and imaging depth of conventional fluorescent imaging is unsatisfactory. Therefore, we present a dual modality imaging technique by combining fluorescence imaging with high-resolution noninvasive photoacoustic tomography (PAT) for the study of an animal tumor model. PAT provides high-resolution structural images of tumor angiogenesis, and fluorescence imaging offers high sensitivity to molecular probes for tumor detection. Coregistration of the PAT and fluorescence images was performed on nude mice with M21 human melanoma cell lines with ..v..3 integrin expression. An integrin ..v..3-targeted peptide-ICG conjugated NIR fluorescent contrast agent was used as the molecular probe for tumor detection. PAT was employed to noninvasively image the brain structure and the angiogenesis associated with tumors in mice. The coregistration between the PAT and fluorescence images was used to visualize tumor location, angiogenesis, and brain structure simultaneously.
Expectation-Maximization (EM) based channel estimation and interpolation in OFDM systems (2012)

Channel estimation and tracking methods are very critical parts of wireless Orthogonal Frequency Division Multiplexing (OFDM) systems in time and frequency selective communication channels. Interpolation has been popularly used in both domains when the channel is sampled with pilot subcarriers. The classical approach is to use the Least Square (LS) estimations to predict the channel for the pilot locations and then use Maximum Likelihood Estimation (MLE) and Minimum Mean Square Error Estimation (MMSEE) schemes to improve these initial estimations and interpolate for deriving a complete characterization of the channel. In this paper, in comb-type pilot arrangement, we propose to use the Expectation-Maximization (EM) algorithm to complement the LS scheme and propose two different approaches: (i) Using a sliding window approach based on EM estimators to interpolate, (ii) Using EM estimations on pilots instead of LS to enhance the MLE and MMSEE performance. Additionally, the necessary condition for EM to work properly is shown in the paper.
Polydopamine used as Hollow Capsule and Core–Shell Structures for Multiple Applications (2015)

Polydopamine (PDA) capsule and core–shell structures with tailored structures and properties are of particular interests due to their multifunctions and potential applications as new colloidal structures in diverse fields. Among the available fabrication methods, PDA film onto colloidal particles followed by selective template removal has attracted extensive attention due to its advantages of precise control over the size, wall thickness and functions of the obtained capsules. The past several years has witnessed a rapid increase of research concerning the new fabrication strategies, functionalization and applications of this kind of capsules and core–shell structures, particularly in many fields such as drug delivery, catalysis, antibacterial, etc. In this review, the very recent progress of the capsule and core–shell structures based on PDA are summarized. There are basically two sections, including the fabrication process of PDA capsules, core–shell structures, and the various applications based on PDA.
Present knowledge of electronic properties and charge transport of icosahedral boron-rich solids (2009)

B12 icosahedra or related structure elements determine the different modifications of elementary boron and numerous boron-rich compounds from α-rhombohedral boron with 12 to YB66 type with about 1584 atoms per unit cell. Typical are well-defined high density intrinsic defects: Jahn-Teller distorted icosahedra, vacancies, incomplete occupancies, statistical occupancies and antisite defects. The correlation between intrinsic point defects and electron deficiencies solves the discrepancy between theoretically predicted metal and experimentally proved semiconducting character. The electron deficiencies generate split-off valence states, which are decisive for the electronic transport, a superposition of band-type and hopping-type conduction. Their share depends on actual conditions like temperature or pre-excitation. The theoretical model of bipolaron hopping is incompatible with numerous experiments. Technical application of the typically p-type icosahedral boron-rich solids requires suitable n-type counterparts; doping and other possibilities are discussed.
Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance (2009)

Given its relative rarity, it may at first seem surprising that chronic myeloid leukemia (CML) has garnered so much attention over the last decade. Yet, the advances in molecular pathogenesis that have been derived from studying this leukemia have clearly benefited all of oncology. Moreover, the strides in drug design and development that have also ensued around CML have given rise to what others have called a molecular revolution in cancer therapy. While a majority of patients with chronic phase CML (CP-CML) have an excellent durable response to imatinib (Gleevec, Novartis, Basel, Switzerland), a clear minority will unfortunately have signs of primary or secondary resistance to therapy. Significant efforts geared toward understanding the molecular mechanisms of imatinib resistance have yielded valuable insights into the biology of drug trafficking into and out of cells, epigenetic control of cellular processes, alterations in enzymatic structures, and the rational structural-based design of small molecule enzyme inhibitors. This review will describe the efforts at understanding the pathogenesis of imatinib resistance and the molecular rationale for the development of second- and now third-generation therapies for patients with CML.
Plasminogen (2011)

The biochemical essence of prion replication is the molecular multiplication of the disease-associated misfolded isoform of prion protein (PrP), termed PrPSc, in a nucleic acid-free manner. PrP(Sc) is generated by the protein misfolding process facilitated by conformational conversion of the host-encoded cellular PrP to PrP(Sc). Evidence suggests that an auxiliary factor may play a role in PrP(Sc) propagation. We and others previously discovered that plasminogen interacts with PrP, while its functional role for PrPSc propagation remained undetermined. In our recent in vitro PrP conversion study, we showed that plasminogen substantially stimulates PrP(Sc) propagation in a concentration-dependent manner by accelerating the rate of PrP(Sc) generation, while depletion of plasminogen, destabilization of its structure, and interference with the PrP-plasminogen interaction hinder PrP(Sc) propagation. Further investigation in cell culture models confirmed an increase of PrP(Sc) formation by plasminogen. Although molecular basis of the observed activity for plasminogen remain to be addressed, our results demonstrate that plasminogen is the first cellular protein auxiliary factor proven to stimulate PrP(Sc) propagation.
Plane wave analysis of coherent holographic image reconstruction by phase transfer (CHIRPT) (2015)

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is, voxel-by-voxel collection of fluorescent light emitted throughout the specimen with a nonimaging single-element detector. While nonimaging fluorescence detection offers some measure of scattering robustness, the rate at which dynamic specimens can be imaged is severely limited. Other fluorescent imaging techniques utilize imaging detection to enhance collection rates. A notable example is light-sheet fluorescence microscopy, also known as selective-plane illumination microscopy, which illuminates a large region within the specimen and collects emitted fluorescent light at an angle either perpendicular or oblique to the illumination light sheet. Unfortunately, scattering of the emitted fluorescent light can cause blurring of the collected images in highly turbid biological media. We recently introduced an imaging technique called coherent holographic image reconstruction by phase transfer (CHIRPT) that combines light-sheet-like illumination with nonimaging fluorescent light detection. By combining the speed of light-sheet illumination with the scattering robustness of nonimaging detection, CHIRPT is poised to have a dramatic impact on biological imaging, particularly for in vivo preparations. Here we present the mathematical formalism for CHIRPT imaging under spatially coherent illumination and present experimental data that verifies the theoretical model.
Design of an air-cooled metallic high-temperature radial turbine (1990)

Recent trends in small advanced gas turbine engines call for higher turbine inlet temperatures. Advances in radial turbine technology have opened the way for a cooled metallic radial turbine capable of withstanding turbine inlet temperatures of 2500 F while meeting the challenge of high efficiency in this small flow size range. In response to this need, a small air-cooled radial turbine has been designed utilizing internal blade coolant passages. The coolant flow passage design is uniquely tailored to simultaneously meet rotor cooling needs and rotor fabrication constraints. The rotor flow-path design seeks to realize improved aerodynamic blade loading characteristics and high efficiency while satisfying rotor life requirements. An up-scaled version of the final engine rotor is currently under fabrication and, after instrumentation, will be tested in the warm turbine test facility at the NASA Lewis Research Center.
Targeted Therapy Alone for Acute Promyelocytic Leukemia (2016)

Patients with acute promyelocytic leukemia who received all-trans retinoic acid (ATRA) plus arsenic trioxide had an event-free survival rate of 96% at 50 months and an overall survival rate of 99%, better results than with ATRA plus chemotherapy (81% and 88%, respectively).
Practical Mobile-DBA Scheme Considering Data Arrival Period for 5G Mobile Fronthaul with TDM-PON (2017)

For mobile fronthaul with TDM-PON, we propose a practical DBA scheme that allocates proper time slots by estimating the data-arrival period from mobile scheduling information. Experiments show that the scheme actually satisfies the fronthaul latency requirement for the first time.
Public health (2007)

In 1850 health provisions in Ireland were patchy. Cities were well supplied with voluntary hospitals for the poor, and most county towns had public infirmaries and fever hospitals. Geary counts 171 hospitals in Ireland by 1845, and 664 charitable dispensaries. The collection of health statistics, urban sanitary reforms and health legislation led to an improvement in what is known as public health. The story of poor William Burke, diagnosed with smallpox, illustrates how developments in commerce and transport aided the spread of disease even as modern public health authorities tried to curb it. Like most social and medical reformers in all countries at the time, they thought of the poor as a particularly disorderly and troublesome organ of that body or sometimes even as waste matter. Many people in Munster recovered from smallpox and measles, but lost their sight, without ever consulting a doctor or becoming a public health statistic.
Control of particle size and phase formation of TiO<sub>2</sub>nanoparticles synthesized in RF induction plasma (2007)

TiO2 nanoparticles have been synthesized in this work via Ar/O2 RF thermal plasma oxidation of atomized liquid precursors containing titanium tetrabutoxide and diethanolamine. Quench gases (Ar or He), either injected from the shoulder of the reactor (transverse injection) or injected counter to the plasma plume from the bottom of the reactor (counter-flow injection), are used to affect the quench rate and therefore the particle size and phase constituent of the resultant powders. The experimental results show that counter-flow injection is more effective in reducing the particle size, while He is more effective than Ar. As a result, well-dispersed TiO2 nanopowders with controllable phase structure (up to ∼90% of anatase) and average particle size (down to 20 nm) are obtained. The experimental results are well supported by numerical analysis on the effects of the quench gas on flow pattern and temperature field of the thermal plasma as well as trajectory and temperature history of the particles.
Extended-Stroke Downhole Power Unit Successfully Pulls Subsea Wellhead Plugs in the Gulf of Mexico (2008)

Abstract Today's need to provide deepwater subsea well servicing has created many new challenges for the industry. For example, pulling a deepwater subsea wellhead or crown plug can require an extreme pulling force. The difficulties experienced can be compounded by conditions when the plug has been in place for extended periods of time as well as the more demanding deepwater conditions, such as high differential forces and settlement on top of the plug that contribute to the need for the higher pulling forces. These conditions often exceed the capabilities of conventional slickline services. As exploration continues to venture into more challenging environments, service companies have had to increase the scope of capabilities of their equipment to meet the challenges brought about by the new environments that require capability for tools to pull high tensile loads. The deepwater subsea arena has been particularly challenging, and this paper will focus on a slickline innovation — an extended-stroke electro mechanical device — that can provide deepwater subsea well interventions more cost-effectively than other service alternatives. The tool is a slickline-deployed electro-mechanical device that is operated by batteries rather than explosives or hydrostatic pressurized tools and can produce a high linear pulling force. Since first being introduced, the electro-mechanical device has undergone several changes that have increased its capabilities and functionality. For example, it has recently been configured for pulling subsea wellhead plugs. This paper will present three case histories that discuss the first use of the ‘extended stroke’ electro mechanical device in the Gulf of Mexico in which it was capable of pulling plugs at a water depth of 5,339 feet as well as several subsequent case histories. Using the slickline electro-mechanical device rather than coiled-tubing resulted in substantial savings in both the cost of deployment and rig time.