gebhart/patrepeval huggingface dataset:
[Paclitaxel (taxol): a review of its antitumor activity and toxicity in clinical studies]. (1998)

Paclitaxel (Taxol) is a new class of anti-tumor agents which act by promoting the assembly and inhibiting the disassembly of microtubules. Single-agent studies have shown its significant activity for advanced cancers in various organs including ovary, lung, breast, and head and neck. Combination therapies with other anticancer agents have been extensively investigated in these cancers. Paclitaxel combined with cisplatin is now considered to be the standard treatment for advanced ovarian cancer. In other cancers, promising results have been obtained in several studies of paclitaxel-based chemotherapy. Major toxicities of paclitaxel-monotherapy are hypersensitivity reaction, neutropenia, and peripheral neuropathy. Combination of other cytotoxic agents sometimes leads to severer toxicities such as neurotoxicity with cisplatin and cardiotoxicity with anthracycline. Although further evaluation is needed, paclitaxel will be a main agent in the treatment of advanced solid tumors.
Product and product-independent induction of butane oxidation in<i>Pseudomonas butanovora</i> (2005)

Pseudomonas butanovora grows on butane by means of an inducible soluble alkane monooxygenase (sBMO). The induction of sBMO was studied using the wild type and a sBMO reporter strain. The reporter strain has the lacZ::kan cassette inserted into bmoX, the gene that encodes the alpha-subunit of the hydroxylase of sBMO. The beta-galactosidase activity in the reporter strain was not induced by butane, but was induced by 1-butanol and butyraldehyde. P. butanovora expressed sBMO product-independent activity at 3.0+/-1 nmol ethylene oxide min(-1) mg protein(-1) in stationary phase. The sBMO product-independent activity likely primes the expression of sBMO by butane.
Bias stability of OC48 x-cut lithium-niobate optical modulators: four years of biased aging test results (2003)

Long-term 100/spl deg/C and 85/spl deg/C biased aging tests on OC48 x-cut lithium-niobate optical intensity modulators have been run for four years. The 100/spl deg/C test results clearly show that the bias voltage does not exhibit the conventional catastrophic growth curve, but rather peaks between 10 000 and 35 000 h at levels well below typically used bias voltage rails (/spl plusmn/12 V). This promises a very high reliability for these x-cut lithium-niobate modulators for long-term bias-drift failure mode. Using the data, a bias-drift failure rate under ordinary operation conditions, 20 years at 40/spl deg/C, is estimated to be <1 failures in time with activation energy of 1.2 eV.
HIV-1-Specific Interleukin-21 <sup>+</sup> CD4 <sup>+</sup> T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8 <sup>+</sup> T Cell Function (2010)

Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent viral infections. To investigate the potential role of IL-21 in a chronic human viral infection, we studied the rare subset of HIV-1 controllers, who are able to spontaneously control HIV-1 replication without treatment. HIV-specific triggering of IL-21 by CD4(+) T cells was significantly enriched in these persons (P = 0.0007), while isolated loss of IL-21-secreting CD4(+) T cells was characteristic for subjects with persistent viremia and progressive disease. IL-21 responses were mediated by recognition of discrete epitopes largely in the Gag protein, and expansion of IL-21(+) CD4(+) T cells in acute infection resulted in lower viral set points (P = 0.002). Moreover, IL-21 production by CD4(+) T cells of HIV controllers enhanced perforin production by HIV-1-specific CD8(+) T cells from chronic progressors even in late stages of disease, and HIV-1-specific effector CD8(+) T cells showed an enhanced ability to efficiently inhibit viral replication in vitro after IL-21 binding. These data suggest that HIV-1-specific IL-21(+) CD4(+) T cell responses might contribute to the control of viral replication in humans and are likely to be of great importance for vaccine design.
The Effects of a Dialysis Solution with a Combination of Glycerol/Amino Acids/Dextrose on the Peritoneal Membrane in Chronic Renal Failure (2010)

Both hypertonic dialysis solutions increased peritoneal solute transport. GLAD exposure was associated with the best preservation of peritoneal morphology. The results of GLAD were very similar to those of the bicarbonate/lactate-buffered solution without osmotic agents. Studies in humans are needed for further assessment of GLAD.
Bilingual sentence alignment: balancing robustness and accuracy. (1996)

Sentence alignment is the problem of making explicit the relations that exist between the sentences of two texts that are known to be mutual translations. Automatic sentence alignment methods typically face two kinds of difficulties. First, there is the question of robustness. In real life, discrepancies between the source-text and its translation are quite common: differences in layout, omissions, inversions, etc. Sentence alignment programs must be ready to deal with such phenomena. Then, there is the question of accuracy. Even when translations are &quot;clean&quot;, alignment is still not a trivial matter: some decisions are hard to make, even for humans. We report here on the current state of our ongoing efforts to produce a sentence alignment program that is both robust and accurate. The method that we propose relies on two new alignment engines, and combines the robustness of so-called &quot;character-based&quot; methods with the accuracy of stochastic translation models. Experimental results are p...
Generation and characterization of reassortant influenza A viruses propagated in serum-free cultured MDCK-SF1 cells. (1999)

The replacement of embryonated chicken eggs by tissue culture cells for the production of influenza vaccines is likely to take place in the near future. Vaccines have already been produced in Madin Darby Canine Kidney (MDCK) cells (Brands et al, in this issue) and extensively tested in phase III trials in humans (Palache et al, in this issue) and it seems a matter of time before such vaccines will become available. For this reason, the generation of high-growth reassortants of influenza A virus strains in MDCK cells has been examined. Influenza A virus reassortants of the field strains A/Taiwan/1/86, A/Johannesburg/82/96 and A/Shenzhen/227/95 (all H1N1) were generated in serum-free cultured MDCK-SF1 cells by dual infection with A/Hong Kong/2/68 (H3N2), a strain selected for its high-growth phenotype. These reassortant viruses all contained at least the matrix gene of A/Hong Kong/2/68 which apparently correlates with an improvement of the viral yield.
Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB (1993)

Thiolactomycin (TLM) and cerulenin are antibiotics that block Escherichia coli growth by inhibiting fatty acid biosynthesis at the beta-ketoacyl-acyl carrier protein synthase I step. Both TLM and cerulenin trigger the accumulation of intracellular malonyl-coenzyme A coincident with growth inhibition, and the overexpression of synthase I protein confers resistance to both antibiotics. Strain CDM5 was derived as a TLM-resistant mutant but remained sensitive to cerulenin. TLM neither induced malonyl-coenzyme A accumulation nor blocked fatty acid production in vivo; however, the fatty acid synthase activity in extracts from strain CDM5 was sensitive to TLM inhibition. The TLM resistance gene in strain CDM5 was mapped to 57.5 min of the chromosome and was an allele of the emrB gene. Disruption of the emrB gene converted strain CDM5 to a TLM-sensitive strain, and the overexpression of the emrAB operon conferred TLM resistance to sensitive strains. Thus, activation of the emr efflux pump is the mechanism for TLM resistance in strain CDM5.
Syntheses of isomers of protoporphyrin‐IX with permuted propionic side‐chains (1985)

Abstract Total syntheses of hemins with permutations of the propionic side‐chains in the C and D rings (compared with protoporphyrin‐IX) are described. The products, 3, 2 and 4 , are the dimethyl esters of protoporphyrins ‐I, ‐XI, and ‐XIV, respectively. They are of interest in connection with nmr studies designed to elucidate the structural features of the heme crevice in myoglobin and the effect of structural modifications of the C and D rings on the kinetics of heme‐apoprotein reconstitutions, as well as studies of substrate specificity of the heme degradation enzyme, heme oxygenase.
Proton magnetic resonance spectroscopy imaging in the study of human brain cancer. (2009)

Magnetic resonance spectroscopic imaging (MRSI) is a non-invasive imaging technique that provides metabolic information on brain tumor. This biochemical information can be processed and presented as density maps of several metabolites, among them N-acetylaspartate (marker of neuronal viability), choline (marker of membrane turnover), creatine (related to the energy state of the cells), myo-Inositol (exclusively found in astrocytes), lipids and lactate (observed in necrosis and other pathological processes) which mean relevant information in the context of brain tumors. Thus, this technique is a multiparametrical molecular imaging method that can complete the magnetic resonance imaging (MRI) study enabling the detection of biochemical patterns of different features and aspects of brain tumors. In this article, the role of MRSI as a molecular imaging technique to provide biochemical information on human brain tumors is reviewed. The most frequent questions and situations in the study of human brain tumors in clinical settings will be considered, as well as the distinction of neoplastic lesions from non neoplastic, the tumor type identification, the study of heterogeneity and infiltration of normal appearing white matter and the therapy following with detection of side effects. The great amount of data in MRSI acquisition compared to the single voxel techniques requires the use of automated methods of quantification, but the possibility to obtain self-reference in the non-affected areas allows different strategies for data handling and interpretation, as presented in the literature. The combination of MRSI with other physiological MRI techniques and positron emission tomography is also included in this review.
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex (2011)

These findings demonstrate that precise microRNA expression is critical for the postnatal development of prefrontal cortical circuitry. Similar defects in neuronal maturation resulting from microRNA deficiency could represent endophenotypes of certain neuropsychiatric diseases of developmental onset.
Alkaline polymer electrolytes containing pendant dimethylimidazolium groups for alkaline membrane fuel cells (2013)

Novel anion exchange membranes (AEMs), based on poly(phenylene oxide) (PPO) chains linked to pendant 1,2-dimethylimidazolium (DIm) functional groups, have been prepared for evaluation in alkaline polymer electrolyte membrane fuel cells (APEFCs). Successful functionalisation of the PPO chains was confirmed using 1H-NMR and FT-IR spectroscopies. The ionic conductivities of the resulting DIm–PPO AEMs at 30 °C are in the ranges of 10–40 mS cm−1 and 18–75 mS cm−1 at 60 °C. The high ionic conductivities are attributed to the highly developed microstructures of the membranes, which feature well-defined and interconnected ionic channels (confirmed by atomic force microscopy, AFM, measurements). Promisingly, the ion-exchange capacities (IECs) of the DIm–PPO AEM are maintained after immersion in an aqueous KOH solution (2 mol dm−3) for 219 h at 25 °C; a previously developed monomethyl imidazolium PPO analogue AEM (Im–PPO) showed a significant decline in IEC on similar treatment. This reduction in undesirable attack by the OH− conducting anions is ascribed to an increase in steric interference and removal of the acidic C2 proton [in the monomethyl Im-groups] by the methyl group in the DIm cationic ring. Moreover, the maximum power densities produced in simple beginning-of-life single cell H2/O2 fuel cell tests increased from 30 mW cm−2 to 56 mW cm−2 when switching from the Im–PPO AEM (fuel cell temperature = 50 °C) to the DIm–PPO-0.54 AEM (fuel cell temperature = 35 °C) respectively (even with the use of lower temperatures).
Successful anatomic correction of transposition of the great vessels. A preliminary report. (1975)

The authors present a new approach for anatomical correction of transposition of the great vessels. The two coronaries with a piece of aortic wall are transposed to the posterior artery. The two aortic openings are closed with a patch. The aorta and pulmonary artery are transected, contraposed and then anastomosed. The interventricular septal defect was closed through a right ventriculotomy with a dacron patch. A 40-dayold white male infant with 3,700 g was operated on with deep hypothermia and total circulatory arrest and made an uneventful recovery. The hemodynamic study 20 days after surgery showed the complete correction of the malformation. At 50 days after surgery, he weighed 5,500 g, without cyanosis and in good conditions.
Synthesis of 5-Methyltubercidin and Its α-Anomer<i>via</i>Condensation of the Anion of 4-Methoxy-5-methyl-2-methylthiopyrrolo [2, 3-d] pyrimidine and 2, 3, 5-Tri-O-benzyl-<scp>d</scp>-ribofuranosyl Bromide (1977)

5-Methyltubercidin and its α-anomer were synthesized from 4-methoxy-5-methyl-2- methylthio-7-(2,3,5-tri-O-benzyl-α- and β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines, which in turn prepared by condensation of anion of 4-methoxy-5-methyl-2-methylthiopyrrolo[2,3-d] pyrimidine with 2,3,5-tri-O-benzyl-d-ribofuranosyl bromide. The anomeric configuration was rigorously established by deriving 5-methyltubercidin to the quaternary cyclonucleoside.
Estimation of the Center of Bodymass During Forward Stepping using Body Acceleration (2006)

The center of body mass (COM) calculation is a key factor in analyzing human postural control. In recent years there have been attempts to estimate the COM by body acceleration during standing. In this study, a parabolic model is used to estimate the COM trajectory during forward stepping, using the body segments' accelerations, which were measured by inexpensive and portable accelerometers placed on the trunk and swing leg. Paced and voluntary forward stepping was performed on different support surfaces and with different speeds of stepping. Forward steps were extracted by analyzing the ankle marker position in vertical direction. The model was calibrated by genetic algorithm and tested on forward stepping data using the leave one out method. The results are encouraging for the use of the proposed model as a mean to estimate the COM trajectory during forward stepping.
Innominate osteotomy in Perthes' disease. A radiological survey of results (1985)

Perthes' disease involving the whole of the femoral head in 36 children was treated by innominate osteotomy. Radiographs of all cases were reviewed to see the effect of the osteotomy on the shape, the degree of acetabular cover and any subluxation of the diseased femoral head. All femoral heads which were circular before operation remained so, and over half of the previously deformed heads became circular after the osteotomy. The improved acetabular cover provided by the osteotomy resulted in a CE angle of 25 degrees or more in 92% of hips. Possible subluxation of the femoral head was studied by inspecting Shenton's line. If this was intact before operation it remained so; of the 14 which were broken before operation, 11 were restored to normal after osteotomy. We conclude that innominate osteotomy is a worthwhile procedure for Perthes' disease involving the whole of the femoral head.
QoS for inter-WLAN IP mobility with high speed accessed network server (2005)

The Mobile IP (MIP) enables a mobile user to access the Internet anywhere with an identical IP address. However, in order to support mobility with quality of service (QoS), MIP can be inefficient for both data and time sensitive services such as voice-over-IP (VoIP). Broadband accessed network server IP mobility architecture facilitates WLAN IP mobility better and can have better QoS performance than the MIP approach. The uniqueness of this architecture is that it obviates the need for MIP for inter-WLAN IP mobility. We have previously presented the proposed architecture in great detail (Rahman, M. and Harmantzis, F., IEEE Wireless Commun. and Networking Conf., WCNC, 2004). We now provide performance analysis results, using QoS metrics and simulation experiments, comparing the existing MIP approach with our central server controlled approach. Our analysis shows that network assisted direct packet routing performs significantly better than the existing MIP in terms of delay and packet loss. We have also shown the impact of mobility management tasks on the network server managing the mobility.
Enzymatic production of 5-aminovalerate from l-lysine using l-lysine monooxygenase and 5-aminovaleramide amidohydrolase (2014)

5-Aminovalerate is a potential C5 platform chemical for synthesis of valerolactam, 5-hydroxyvalerate, glutarate, and 1,5-pentanediol. It is a metabolite of l-lysine catabolism through the aminovalerate pathway in Pseudomonas putida. L-Lysine monooxygenase (DavB) and 5-aminovaleramide amidohydrolase (DavA) play key roles in the biotransformation of L-lysine into 5-aminovalerate. Here, DavB and DavA of P. putida KT2440 were expressed, purified, and coupled for the production of 5-aminovalerate from L-lysine. Under optimal conditions, 20.8 g/L 5-aminovalerate was produced from 30 g/L L-lysine in 12 h. Because L-lysine is an industrial fermentation product, the two-enzyme coupled system presents a promising alternative for the production of 5-aminovalerate.
Systemic sclerosis and digital gangrene without scleroderma. (1988)

We report a case of a 67-year-old man with digital gangrene and no other cutaneous evidence of scleroderma. The presence of anticentromere antibody, scleroderma pattern capillary abnormalities, and the histology of the digital artery all supported a diagnosis of systemic sclerosis. Newer diagnostic tools may identify patients who do not fit easily into the current classification of that disease.
Microfluidics with in situ Raman spectroscopy for the characterization of non-polar/aqueous interfaces (2016)

The design of microfluidics with <italic>in situ</italic> Raman spectroscopy is reported in the present work for the investigation of immiscible non-polar/aqueous interactions.
REVIEWS (1922)

REVIEWS Get access The Babylonian Talmud: Tractate Berākot. Translated into English for the first time, with Introduction, Commentary, Glossary, and Indices, by A. COHEN, ( Cambridge University Press, 1921.) pp. xxxix + 460. G. H. BOX G. H. BOX Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume os-XXIV, Issue 93, October 1922, Pages 105–108, https://doi.org/10.1093/jts/os-XXIV.93.105 Published: 01 October 1922
Histone-like proteins from fish are lethal to the parasitic dinoflagellate <i>Amyloodinium ocellatum</i> (2001)

Antimicrobial proteins were purified from acid extracts of rainbow trout (Oncorhynchus mykiss) and sunshine bass (Morone saxatilis male x M. chrysops female) skin, gill and spleen by reverse-phase HPLC. Mass spectrometry and amino acid sequence data suggest that these proteins are closely related to histone H2B and histone H1 and thus they were designated histone-like proteins (HLPs). These proteins were lethal to Amyloodinium ocellatum, which is one of the most important parasitic agents affecting fish. Antibiotic concentrations as low as 12.5 microg/ml were inhibitory. Activity was directed against the trophont (feeding) stage of the parasite, while the disseminative (dinospore) stage was unaffected. Thus, HLPs act unlike typical drugs used to treat amyloodiniosis, which usually target the dinospore. Both the ability of the parasite to infect host cells, as well as the ability to grow and differentiate after infection were severely inhibited. This is in contrast to magainin 2, which was similarly toxic to both the dinospore and trophont stages. These findings provide further evidence that histone-like proteins may be important defensive molecules in fish.
Blueberry (Vaccinium corymbosum L.) (2006)

Recent advances in plant biotechnology have led to a reliable and reproductive method for genetic transformation of blueberry. These efforts built on previous attempts at transient and stable transformation of blueberry that demonstrated the potential of Agrobacterium tumefaciens-mediated transformation, and as well, the difficulties of selecting and regenerating transgenic plants. As a prerequisite for successful stable transformation, efficient regeneration systems were required despite many reports on factors controlling shoot regeneration from leaf explants. The A. tumefaciens-mediated transformation protocol described in this chapter is based on combining efficient regeneration methods and the results of A. tumefaciens-mediated transient transformation studies to optimize selected parameters for gene transfer. The protocol has led to successful regeneration of transgenic plants of four commercially important highbush blueberry cultivars.
Adaptive User Interfaces Based on Mobile Agents: Monitoring the Behavior of Users in a Wireless Environment (2005)

Abstract Adapting user interfaces to meet users &apos; context and preferences is one of the most challenging questions of mobile computing. In the mobile world, every application must be aware of the dioeerent user devices, application platforms and contexts where it should execute; the alternative is reimplementing the same user interface to meet dioeerent device capabilities. This paper presents a proposal based on mobile agents that transparently adapts user interfaces to the corresponding device capabilities and monitors the user behavior using an indirect user interface generation mechanism. User behavior patterns are used to predict users &apos; next most probable action. We apply this approach to a software retrieval service to show its feasibility. Keywords: Adaptive user interfaces, mobile computing, mobile agents and multiagent systems
Phosphorus utilization in chicks fed hydrated sodium calcium aluminosilicate. (1990)

Two experiments were conducted to evaluate the effects of hydrated Na Ca aluminosilicate (HSCAS) on P utilization of young broiler chicks. Phosphorus-deficient corn-soybean meal diets containing .36% (.134% available) P and 1% Ca were fortified with 0, .05 and .10% P provided as KH2PO4 (22.8% P) or feed-grade dicalcium phosphate (18.9% P). Diets were available ad libitum to chicks receiving 0, .50 or 1.0% HSCAS during the period 8 to 22 d posthatching. Weight of tibia ash, percentage of tibia ash and bone-breaking force were regressed on supplemental P intake to assess P utilization in the absence or presence of HSCAS. Tibia parameters (ash weight, percentage of ash and bone-breaking force) responded linearly (P < .01) to P supplementation. Regardless of P source (KH2PO4 or dicalcium phosphate), .5% or 1.0% HSCAS had no effect (P > .1) on P utilization. With no supplemental P, tibia parameters also were not affected (P > .05) by HSCAS. Phosphorus utilization from dicalcium phosphate was estimated to be 87% as efficient as that observed for KH2PO4. The results suggest that dietary HSCAS does not impair utilization of either phytate or inorganic P.