gebhart/patrepeval huggingface dataset:
Substance P Has a Role in Neurogenic Mediation of Human Burn Wound Healing (1996)

Knowledge of biochemical and molecular events during burn wound healing may optimize treatment of patients with thermal injuries. Substance P (SP), a neuropeptide present in C fibers of the skin, has been implicated as a mediator of inflammation and wound healing. This neuropeptide induces vasodilitation and vascular permeability by stimulating endothelial cells to round up, vascular smooth cells to relax, and mast cells to release histamine. SP also induces cytokine release by macrophages and neutrophils. Because many of the functions of SP seemed relevant to wound repair in burns, we used immunocytochemistry to characterize SP+ nerve fibers in healing human burn wounds. Deep partial-thickness burns collected from 20 patients at the time of excision and grafting were formalin fixed, paraffin-embedded, sectioned, and labeled with a monoclonal antibody to SP with use of an immunoperoxidase technique. Our tissue samples included normal skin and 20 specimens from postburn days 2 through 49. In normal adult skin, SP+ nerve fibers surrounded vessels throughout the skin and extended from the papillary dermis into the epidermis. SP+ fibers were absent in early wound beds. SP immunostaining did occur in the advancing epidermis, endothelial cells, and mast cells. SP+ fibers could be identified in the deep dermis and subjacent to the advancing epithelium before the wound beds. Maximum numbers of SP+ fibers were present subjacent to the advancing epithelium at 2 weeks after burn injury. After 4 weeks, the distribution of SP+ fibers in reepithelialized areas was similar to that of normal skin. Our data corroborate published reports of SP+ fiber regeneration in guinea pig burns and correlates with clinical observations of pain and pruritus in patients with thermal injuries. The absence of SP+ fibers in the early wounds with SP immunostaining in the epidermis and extracellular matrix suggests that SP may be released from injured nerves and supports neurogenic mediation of inflammation and vasodilitation in early wound repair. Repopulation of the wound beds with SP+ fibers appeared to follow neovascularization originating in the deep reticular dermis and wound edge.
Regioselective 1,3-Dipolar Cycloaddition Reaction of Azides with Alkoxy Alkynyl Fischer Carbene Complexes (2010)

ADVERTISEMENT RETURN TO ISSUEPREVNoteRegioselective 1,3-Dipolar Cycloaddition Reaction of Azides with Alkoxy Alkynyl Fischer Carbene ComplexesAmarnath Chakraborty, Surjendu Dey, Sudeshna Sawoo, N. N. Adarsh†, and Amitabha Sarkar*View Author Information Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India*To whom correspondence should be addressed. E-mail: [email protected]†Crystal structure determination.Cite this: Organometallics 2010, 29, 23, 6619–6622Publication Date (Web):November 1, 2010Publication History Received1 October 2010Published online1 November 2010Published inissue 13 December 2010https://pubs.acs.org/doi/10.1021/om1009523https://doi.org/10.1021/om1009523brief-reportACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views1812Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Addition reactions,Azides,Cyclization,Fischer Carbenes,Hydrocarbons Get e-Alerts
CXCL9: evidence and contradictions for its role in tumor progression (2016)

Chemokines are a group of low molecular weight peptides. Their major function is the recruitment of leukocytes to inflammation sites, but they also play a key role in tumor growth, angiogenesis, and metastasis. In the last few years, accumulated experimental evidence supports that monokine induced by interferon (IFN)-gamma (CXCL9), a member of CXC chemokine family and known to attract CXCR3- (CXCR3-A and CXCR3-B) T lymphocytes, is involved in the pathogenesis of a variety of physiologic diseases during their initiation and their maintenance. This review for the first time presents the most comprehensive summary for the role of CXCL9 in different types of tumors, and demonstrates its contradictory role of CXCL9 in tumor progression. Altogether, this is a useful resource for researchers investigating therapeutic opportunities for cancer.
The Pressure-Volume-Temperature Properties of Perfluorocyclobutane Equations of State, Vital Coefficients, and Intermolecular Potential Energy Functions (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Pressure-Volume-Temperature Properties of Perfluorocyclobutane Equations of State, Vital Coefficients, and Intermolecular Potential Energy FunctionsD. R. Douslin, R. T. Moore, and Guy WaddingtonCite this: J. Phys. Chem. 1959, 63, 11, 1959–1966Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://doi.org/10.1021/j150581a037RIGHTS & PERMISSIONSArticle Views87Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (826 KB) Get e-Alerts
Shape Oscillations and Stability of Charged Microdroplets (2002)

Classical Rayleigh theory predicts an instability of a surface charged liquid sphere, when the Coulomb energy ${E}_{C}$ exceeds twice the surface energy ${E}_{S}$. Previously, electrified liquid droplets have been found to disintegrate at a fissility $X={E}_{C}/2{E}_{S}$ well below one, however. We determine the stability of charged droplets in an electrodynamic levitator by observing the amplitude and phase of their quadrupolar shape oscillations as a function of the fissility. With this novel approach, which does not rely on an independent determination of the charge and surface tension of the droplets, we are able to confirm for the first time the Rayleigh limit of stability at $X=1$ for micrometer sized droplets of ethylene glycol.
THE CLAY MINERAL CONCEPT (1965)

IT IS NOW GENERALLY AGREED THAT SOILS, CLAYS, AND SHALES ARE COMPOSED OF EXTREMELY SMALL PARTICLES OF A FEW MINERALS KNOWN AS THE CLAY MINERALS. CLAY MINERALS ARE GENERALLY CRYSTALLINE - SOME CLAYS CONTAIN MATERIAL AMORPHOUS TO DIFFRACTION TECHNIQUES, BUT SUCH MATERIAL IS BELIEVED TO BE RELATIVELY RARE. STRUCTURE AND COMPOSITION OF THE CLAY MINERALS DETERMINE THEIR PROPERTIES WHICH IN TURN LARGELY DETERMINE BULK PROPERTIES OF THE CLAY ITSELF. CLAY MINERAL COMPOSITION OF ARGILLACEOUS MATERIAL IS OFTEN COMPLEX BECAUSE OF THE MIXING OF MINERALS INDISCRETE PARTICLES AND/ OR AS MIXED-LAYER ASSEMBLAGES. STRUCTURE AND COMPOSITION ARE BRIEFLY REVIEWED FROM THE POINT OF VIEW OF THE INFLUENCE OF THE ATOMIC ARRANGEMENT AND DEGREE OF STRUCTURAL ORDER ON PHYSICAL PROPERTIES. CERTAIN CHARACTERISTICS OF THE CLAY MINERALS, SUCH AS ION EXCHANGE, WATER ABSORPTION, AND REACTION WITH ORGANIC COMPOUNDS, ARE OF A SPECIAL INTEREST IN A CONSIDERATION OF THE CERAMIC PROPERTIES OF CLAY. /AUTHOR/
A new role for an old molecule: serotonin as a mitogen (1997)

Serotonin (5-hydroxytryptamine) has been known for the last half century to influence vasoactivity and to participate in neurotransmission. More recently, this compound has been recognized to cause proliferation of a variety of cells in culture, including those of vascular smooth muscle. Furthermore, the proliferative effect is synergistic with that of more conventional growth-producing polypeptides. A hypertrophic, as well as a proliferative response, has been shown to occur in some smooth muscle cells. Whether the mitogenic effect is initiated through a cell surface receptor or a serotonin transporter, or both depending on the cell type, is currently unresolved. Most evidence indicates that cellular cyclic nucleotides play an important role in the intracellular signaling process for growth regulation by serotonin, and newer studies point to protein phosphorylation pathways as being important in the mitogenic response. It has been proposed that, through these signaling pathways, serotonin plays an important role in remodeling of both the pulmonary and systemic circulations.
Similarity matching of continuous melody contours for humming querying of melody databases (2004)

Music query-by-humming is a challenging problem since the humming query inevitably contains much variation and inaccuracy. In this paper, we present a novel melody similarity matching technique, which is based on continuous melody contour. We introduce a contour alignment technique, which addresses the robustness and efficiency issues. We also present a new melody similarity metric, which is performed directly on continuous melody contours of the query data. This approach cleanly separates the alignment and similarity measurement in the retrieval process. Our melody alignment method can reduce the matching candidate to 1.7% with 90% correct alignment rate. The overall retrieval system achieved 88% correct retrieval in the top 20 rank lists.
Forming Crystalline Polymer‐Nano Interphase Structures for High‐<scp>M</scp>odulus and High‐<scp>T</scp>ensile/<scp>S</scp>trength Composite Fibers (2013)

PVA/single‐walled nanotube (SWNT) composite fibers are fabricated using a steady shear‐flow gel‐spinning method. The resultant fibers show excellent tensile strength, modulus, and toughness of 4.9 GPa, 128 GPa, and 202 J · g −1 , respectively. Templated interfacial crystallization of PVA in the vicinity of SWNT is controlled by tailoring the degree of undercooling of PVA during the composite solution preparation. WAXD shows that the templated crystallization behavior of the PVA at the SWNT interfacial region is new. PVA/SWNT fibers that exhibit interfacial structure show a predominant crystallization plane of (001) as compared to the (101) plane seen in PVA/SWNT fibers without a distinct interfacial structure. This demonstrates that the PVA interfacial region around SWNT has denser crystalline chain‐packing. image
Dihydropyrancarboxamides Related to Zanamivir:  A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4<i>H</i>-pyran-6-carboxamides (1998)

4-Amino- and 4-guanidino-4H-pyran-6-carboxamides 4 and 5 related to zanamivir (GG167) are a new class of inhibitors of influenza virus sialidases. Structure−activity studies reveal that, in general, secondary amides are weak inhibitors of both influenza A and B viral sialidases. However, tertiary amides, which contain one or more small alkyl groups, show much greater inhibitory activity, particularly against the influenza A virus enzyme. The sialidase inhibitory activities of these compounds correlate well with their in vitro antiviral efficacy, and several of the most potent analogues displayed useful antiviral activity in vivo when evaluated in a mouse model of influenza A virus infection. Carboxamides which were highly active sialidase inhibitors in vitro also showed good antiviral activity in the mouse efficacy model of influenza A infection when administered intranasally but displayed modest activity when delivered by the intraperitoneal route.
Enabling high performance cloud computing using zero touch provisioning (2015)

For over a decade, the data requirements of e-Science applications increase drastically with the emergence of data-intensive applications. The efficient usage of these complex applications that involve the composition of services horizontally, but also vertically across multiple networks, demand a guaranteed level of quality of service to be provided. At the same time user requirements remain strict on not overburdening users with too many configuration tasks and deep knowledge of the underlying components. Aiming to provide the means to employ multiple cloud services for collaborative e-Science project in this paper we explore the possibilities of the zero touch provisioning concepts used on top of a dedicated on-demand establishment of direct customer-provider routes within the European Research and Educational Network - GEANT.
Table of Surface-Active Agents (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTable of Surface-Active AgentsF. J. Van AntwerpenCite this: Ind. Eng. Chem. 1941, 33, 1, 16–22Publication Date (Print):January 1, 1941Publication History Published online1 May 2002Published inissue 1 January 1941https://pubs.acs.org/doi/10.1021/ie50373a004https://doi.org/10.1021/ie50373a004research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Roles of Prolyl Isomerases in RNA-Mediated Gene Expression (2015)

The peptidyl-prolyl cis-trans isomerases (PPIases) that include immunophilins (cyclophilins and FKBPs) and parvulins (Pin1, Par14, Par17) participate in cell signaling, transcription, pre-mRNA processing and mRNA decay. The human genome encodes 19 cyclophilins, 18 FKBPs and three parvulins. Immunophilins are receptors for the immunosuppressive drugs cyclosporin A, FK506, and rapamycin that are used in organ transplantation. Pin1 has also been targeted in the treatment of Alzheimer's disease, asthma, and a number of cancers. While these PPIases are characterized as molecular chaperones, they also act in a nonchaperone manner to promote protein-protein interactions using surfaces outside their active sites. The immunosuppressive drugs act by a gain-of-function mechanism by promoting protein-protein interactions in vivo. Several immunophilins have been identified as components of the spliceosome and are essential for alternative splicing. Pin1 plays roles in transcription and RNA processing by catalyzing conformational changes in the RNA Pol II C-terminal domain. Pin1 also binds several RNA binding proteins such as AUF1, KSRP, HuR, and SLBP that regulate mRNA decay by remodeling mRNP complexes. The functions of ribonucleoprotein associated PPIases are largely unknown. This review highlights PPIases that play roles in RNA-mediated gene expression, providing insight into their structures, functions and mechanisms of action in mRNP remodeling in vivo.
An internal deletion enhances the transcriptional activity of a recombinant retrovirus in hematopoietic cells in vivo (1994)

Lv-myc is a recombinant retrovirus that spontaneously arose during experiments designed to express the provirus LNAv-myc in the hematopoietic system of bone marrow-reconstituted mice (L. Bonham, K. MacKenzie, S. Wood, P. B. Rowe, and G. Symonds, Oncogene 7:2219-2229, 1992). The recombinant provirus is of interest because it is able to promote long terminal repeat-initiated transcription in hematopoietic cells in vivo, whereas the parental provirus, LNAv-myc, is transcriptionally repressed in the same cells. Here we report that Lv-myc was generated by precise deletion of the neomycin resistance gene (neo) and the human gamma-actin promoter from LNAv-myc. In comparison with LNAv-myc, no sequence alterations in the viral regulatory regions of Lv-myc were detected. Thus, it appears that neo and/or the gamma-actin promoter exerted a cis-acting repressor effect on the long terminal repeat of LNAv-myc in vivo. The origin of Lv-myc was also investigated, and it was shown that Lv-myc was harbored as a productive provirus in a G418-resistant subpopulation of the LNAv-myc producer cell line, psi 2AV. It appears that Lv-myc arose during propagation of the psi 2AV cell line. Repeated sequence detected at the sites of the deletion suggest that Lv-myc was generated by a template misalignment during reverse transcription of LNAv-myc.
Beyond spatial pyramids: Receptive field learning for pooled image features (2012)

In this paper we examine the effect of receptive field designs on classification accuracy in the commonly adopted pipeline of image classification. While existing algorithms usually use manually defined spatial regions for pooling, we show that learning more adaptive receptive fields increases performance even with a significantly smaller codebook size at the coding layer. To learn the optimal pooling parameters, we adopt the idea of over-completeness by starting with a large number of receptive field candidates, and train a classifier with structured sparsity to only use a sparse subset of all the features. An efficient algorithm based on incremental feature selection and retraining is proposed for fast learning. With this method, we achieve the best published performance on the CIFAR-10 dataset, using a much lower dimensional feature space than previous methods.
Nanoporous Silica-Dye Microspheres for Enhanced Colorimetric Detection of Cyclohexanone (2018)

Forensic detection of non-volatile nitro explosives poses a tough analytical challenge. A colorimetric sensor comprising ultrasonically prepared silica-dye microspheres was developed for sensitive gas detection of cyclohexanone, a volatile marker of explosives 1,3,5-trinitro-1,3,5-triazinane (RDX) and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX). The silica-dye composites were synthesized from the hydrolysis of ultrasonically sprayed organosiloxanes under mildly heating conditions (150 oC), which yields microspherical, nanoporous structures with high surface area (~300 m2/g) for gas exposure. The sensor inks were deposited on cellulose paper and gave sensitive colorimetric responses to trace amount of cyclohexanone vapors even at sub-ppm levels, with the detection limit down to ~150 ppb. The sensor showed high chemical specificity towards cyclohexanone against humidity and other classes of common solvents, including ethanol, acetonitrile, ether, ethyl acetate, and ammonia. Paper-based colorimetric sensors with hierarchical nanostructures could represent an alternative sensing materials for practical applications in the detection of explosives.
A novel peak amplitude and time detector for narrow pulse signals (1986)

The requirements for a peak amplitude and time detector for applications such as time-of-flight mass spectrometers are derived. A nonlinear feedback structure is found best suited to meet these demands. The novel structure is analyzed and optimized with respect to the ideal behavior and the influence of parasitics. Based on the results, a thick-film hybrid peak detector with an integral nonlinearity of less than 0.3 percent is presented. The output signal varies with pulse shape and pulsewidth (10–250 ns) by less than 10 percent within a pulse amplitude range of 50 dB.
Reliable broadcasting in product networks in the presence of faulty nodes (2002)

Product networks define a class of topologies used very often as interconnection networks for multicomputers such as meshes, tori and hypercubes. In this paper we define the maximal number of node-disjoint paths in a product network and characterize the number of shortest paths among them. The construction of a maximal number of spanning trees allows an operational broadcasting in the product network even in the presence of a maximal number (equal to the nodes's connectivity) of node failures, given that the unique paths to a given node in each spanning tree are mutually node-disjoint. Additionally, even if there are more faulty nodes than the graph's connectivity, such that theoretically the broadcasting may fail, the probability of the network to be non-operational is shown to be quite small. Compared with other reliable broadcasting algorithms, for instance in faulty hypercubes, our broadcasting scheme requires less time.
Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer (2009)

The decalcifying agents under investigation were all able to remove or prevent a smear layer. However, they eroded the dentine wall differently.
Malignant neoplasms following bone marrow transplantation (1996)

We undertook an analysis of 2,150 recipients of bone marrow transplant (BMT) at the University of Minnesota to determine the incidence of post- BMT malignant neoplasms (MNs). Fifty-one patients developed 53 MNs, compared with 4.3 expected from general population rates (standardized incidence ratio [SIR], 11.6, 95% confidence interval [CI], 8.2–14.5). These included 22 occurrences of B-cell lymphoproliferative disorder (BLPD), 17 solid nonhematopoietic tumors, 10 myelodysplastic syndromes (MDS), 1 acute myelogenous leukemia (AML), 2 non-Hodgkin's lymphoma (NHL), and 1 Hodgkin's disease (HD). The estimated actuarial incidence of any post-BMT malignancy was 9.9% +/- 2.3% at 13 years posttransplant. The cumulative probability of BLPD plateaued at 1.6% +/- 0.3% by 4 years from transplant and factors independently associated with increased risk included in vitro T-cell depletion of marrow (relative risk (RR) = 11.9, P < .001), HLA mismatch (RR = 8.9, P < .001), use of antithymocyte globulin (ATG) for graft versus host disease (GVHD) prophylaxis (RR = 5.9, P < .001) or in the preparative regimen (RR = 3.1, P = .03) and primary immunodeficiency (RR = 2.5, P = .06). The cumulative probability of developing solid malignancy was 5.6% +/- 2.2% at 13 years from BMT. Malignant melanomas were the most common (SIR, 10.3, 95% CI 1.9 to 25.4). The actuarial incidence of MDS/AML plateaued at 2.1% +/- 0.8% at 9 years and was seen most often in older patients receiving autologous peripheral blood stem cells for HD or NHL. These data document that BMT recipients are at an increased risk of later malignancy, which may add significant morbidity and mortality to the transplant process. Methods for screening and identification of individuals at increased risk need to be addressed in future studies.