gebhart/patrepeval huggingface dataset:
Use of an In Vitro Pharmacodynamic Model To Derive a Linezolid Regimen That Optimizes Bacterial Kill and Prevents Emergence of Resistance in <i>Bacillus anthracis</i> (2008)

Simulating the average non-protein-bound (free) human serum drug concentration-time profiles for linezolid in an in vitro pharmacodynamic model, we characterized the pharmacodynamic parameter(s) of linezolid predictive of kill and for prevention of resistance in Bacillus anthracis. In 10-day dose-ranging studies, the average exposure for > or =700 mg of linezolid given once daily (QD) resulted in >3-log CFU/ml declines in B. anthracis without resistance selection. Linezolid at < or =600 mg QD amplified for resistance. With twice-daily (q12h) dosing, linezolid at > or =500 mg q12 h was required for resistance prevention. In dose fractionation studies, killing of B. anthracis was predicted by the area under the time-concentration curve (AUC)/MIC ratio. However, resistance prevention was linked to the maximum serum drug concentration (C(max))/MIC ratio. Monte Carlo simulations predicted that linezolid at 1,100 mg QD would produce in 96.7% of human subjects a free 24-h AUC that would match or exceed the average 24-h AUC of 78.5 mg x h/liter generated by linezolid at 700 mg QD while reproducing the shape of the concentration-time profile for this pharmacodynamically optimized regimen. However, linezolid at 700 mg q12h (cumulative daily dose of 1,400 mg) would produce an exposure that would equal or exceed the average free 24-h AUC of 90 mg x h/liter generated by linezolid at 500 mg q12h in 93.8% of human subjects. In conclusion, in our in vitro studies, the QD-administered, pharmacodynamically optimized regimen for linezolid killed drug-susceptible B. anthracis and prevented resistance emergence at lower dosages than q12h regimens. The lower dosage for the pharmacodynamically optimized regimen may decrease drug toxicity. Also, the QD administration schedule may improve patient compliance.
Monolithic Gridless 1 × 2 Wavelength-Selective Switch in Silicon (2011)

We present a monolithic 1 × 2 wavelength-selective switch in silicon nitride and silicon waveguides. The size is only 5.5 mm × 3.0 mm, and the switching is gridless with 32 pixels on a pitch of 100 GHz.
To Beta or Not To Beta: Information Bottleneck for DigitaL Image Forensics (2019)

We consider an information theoretic approach to address the problem of identifying fake digital images. We propose an innovative method to formulate the issue of localizing manipulated regions in an image as a deep representation learning problem using the Information Bottleneck (IB), which has recently gained popularity as a framework for interpreting deep neural networks. Tampered images pose a serious predicament since digitized media is a ubiquitous part of our lives. These are facilitated by the easy availability of image editing software and aggravated by recent advances in deep generative models such as GANs. We propose InfoPrint, a computationally efficient solution to the IB formulation using approximate variational inference and compare it to a numerical solution that is computationally expensive. Testing on a number of standard datasets, we demonstrate that InfoPrint outperforms the state-of-the-art and the numerical solution. Additionally, it also has the ability to detect alterations made by inpainting GANs.
Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A (2004)

Efficient and highly stereoselective syntheses of cryptophycin B and arenastatin A, potent cytotoxic agents, are described. An ester-derived titanium enolate mediated <i>syn</i>-aldol reaction was employed to generate the stereocenters C-5 and C-6. The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycins as well as members of its family.
Tunable and laser-reconfigurable 2D heterocrystals obtained by epitaxial stacking of crystallographically incommensurate Bi <sub>2</sub> Se <sub>3</sub> and MoS <sub>2</sub> atomic layers (2017)

Vertical stacking is widely viewed as a promising approach for designing advanced functionalities using two-dimensional (2D) materials. Combining crystallographically commensurate materials in these 2D stacks has been shown to result in rich new electronic structure, magnetotransport, and optical properties. In this context, vertical stacks of crystallographically incommensurate 2D materials with well-defined crystallographic order are a counterintuitive concept and, hence, fundamentally intriguing. We show that crystallographically dissimilar and incommensurate atomically thin MoS<sub>2</sub> and Bi<sub>2</sub>Se<sub>3</sub> layers can form rotationally aligned stacks with long-range crystallographic order. Our first-principles theoretical modeling predicts heterocrystal electronic band structures, which are quite distinct from those of the parent crystals, characterized with an indirect bandgap. Experiments reveal striking optical changes when Bi<sub>2</sub>Se<sub>3</sub> is stacked layer by layer on monolayer MoS<sub>2</sub>, including 100% photoluminescence (PL) suppression, tunable transmittance edge (1.1→0.75 eV), suppressed Raman, and wide-band evolution of spectral transmittance. Disrupting the interface using a focused laser results in a marked the reversal of PL, Raman, and transmittance, demonstrating for the first time that in situ manipulation of interfaces can enable "reconfigurable" 2D materials. We demonstrate submicrometer resolution, "laser-drawing" and "bit-writing," and novel laser-induced broadband light emission in these heterocrystal sheets.
Experienced mental workload, perception of usability, their interaction and impact on task performance (2018)

Past research in HCI has generated a number of procedures for assessing the usability of interacting systems. In these procedures there is a tendency to omit characteristics of the users, aspects of the context and peculiarities of the tasks. Building a cohesive model that incorporates these features is not obvious. A construct greatly invoked in Human Factors is human Mental Workload. Its assessment is fundamental for predicting human performance. Despite the several uses of Usability and Mental Workload, not much has been done to explore their relationship. This empirical research focused on I) the investigation of such a relationship and II) the investigation of the impact of the two constructs on human performance. A user study was carried out with participants executing a set of information-seeking tasks over three popular web-sites. A deep correlation analysis of usability and mental workload, by task, by user and by classes of objective task performance was done (I). A number of Supervised Machine Learning techniques based upon different learning strategy were employed for building models aimed at predicting classes of task performance (II). Findings strongly suggests that usability and mental workload are two non overlapping constructs and they can be jointly employed to greatly improve the prediction of human performance.
<sup>111</sup> In Platelet Scintigraphy for the Noninvasive Detection of Carotid Plaque Thrombosis (2001)

Indium-platelet scintigraphy is an accurate noninvasive diagnostic tool to detect thrombotic complications in carotid plaques. Prospective studies should assess its ultimate value in risk stratification, possibly to guide the decision of whether to perform endarterectomy in selected patient categories.
Dynamic Object Tracking Control for a Non-Holonomic Wheeled Autonomous Robot (2009)

This paper is devoted to design and implement a non-holonomic wheeled mobile robot that possesses dynamic object-tracking capability by using real-time image processing. Two motion control laws are proposed using Lyapunov’s direct method and computed-torque method. Simulation results illustrate the effectiveness of the developed schemes. The overall experimental setup of the mobile robot developed in this paper is composed of a Windows based personal computer, Programmable Interface Controllers, a mobile robot, and an omni-directional vision system. Finally, the image-based real-time implementation experiments of the mobile robot demonstrate the feasibility and effectiveness of the proposed schemes.
The Optimization of Complex XML Queries over XML Streams under DTD (2006)

Time and Space complexity is a critical factor for a successful stream-based continuous query processing system. In this paper, we address the optimization of complex XML queries over XML Streams by using the semantic and structural constraints of its DTD. The optimization is preprocessed before the runtime of matching XML stream against user's queries in order to simplify XPathes. An approach that processes complex twig patterns with OR-predicates and AND-predicates over XML document streams is also described in this paper, which can be also be used without DTDs.
Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer (2003)

DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the susceptibility to smoking-related cancers. Recently, several polymorphisms have been identified in the xeroderma pigmentosum group G (XPG) gene, and it is possible that these polymorphisms may affect the DNA repair capacity, thereby modulating cancer susceptibility. We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer. The study population consisted of 310 lung cancer patients and 311 healthy controls who were frequency (1:1) matched based on age and sex. The Asp/Asp genotype was more frequent in the controls (28.9%) than in the cases (18.7%) and associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.37-0.80] when the combined His/His and His/Asp genotype was used as the reference. The protective effect of the Asp/Asp genotype against lung cancer was statistically significant in the older subjects (adjusted OR = 0.51, 95% CI = 0.37-0.80), males (adjusted OR = 0.54, 95% CI = 0.35-0.83), and lighter smokers (adjusted OR = 0.48, 95% CI = 0.25-0.94) in a stratification analysis. When the lung cancers were analyzed by histologic type, the Asp/Asp genotype was associated with a significantly decreased risk of squamous cell carcinoma (adjusted OR = 0.55, 95% CI = 0.34-0.88) and small cell lung cancer (adjusted OR = 0.44, 95% CI = 0.20-0.97), but non-significant decreased risk of adenocarcinoma (adjusted OR = 0.64, 95% CI = 0.36-1.12). These results suggest that the XPG codon 1104 polymorphism contributes to genetic susceptibility to lung cancer.
Vinculin is a component of an extensive network of myofibril-sarcolemma attachment regions in cardiac muscle fibers. (1983)

Immunofluorescent staining of bovine and avian cardiac tissue with affinity-purified antibody to chicken gizzard vinculin reveals two new sites of vinculin reactivity. First, vinculin is organized at the sarcolemma in a striking array of rib-like bands, or costameres. The costameres encircle the cardiac muscle cell perpendicular to the long axis of the fiber and overlie the I bands of the immediately subjacent sarcomeres. The second new site of vinculin reactivity is found in bovine cardiocytes at tubular invaginations of the plasma membrane. The frequency and location of these invaginations correspond to the known frequency and distribution of the transverse tubular system in bovine atrial, ventricular, and Purkinje fibers. We do not detect tubular invaginations that stain with antivinculin in avian cardiocytes and, in fact, a transverse tubular system has not been found in avian cardiac fibers. Apparent lateral Z-line attachments to the sarcolemma and its invaginations have been observed in cardiac muscle by electron microscopy in the same regions where we find vinculin. On the basis of these previous ultrastructural findings and our published evidence for a physical connection between costameres and the underlying myofibrils in skeletal muscle, we interpret the immunofluorescence data of this study to mean that, in cardiac muscle, vinculin is a component of an extensive system of lateral attachment of myofibrils to the plasma membrane and its invaginations.
Influence of Polyethylene Glycols on the Percolation Behavior of Anionic and Nonionic Water-in-Oil Microemulsions (1997)

Replacing a proportion of water by oligo- and polyethylene glycols (PEGs) in water-in-oil (w/o) microemulsions strongly affects the phase boundaries and the percolation behavior of these systems. The influence of ethylene glycol (EG) and PEG on systems stabilized by ionic Aerosol OT (AOT) and nonionic Igepal CO-520 (IG) surfactants is examined using electric conductivity and time-resolved electric birefringence (Kerr-effect) measurements. Addition of ethylene glycol induces percolation in AOT microemulsions but stabilizes droplets in IG systems. This effect of EG is contrary to almost all other solutes, stabilizing the same structure in ionic and nonionic systems. It can be understood by the different interaction of EG with the solvated polar headgroups of AOT and IG respectively. Regarding the molecular weight dependence one can distinguish three regimes in the AOT system: Small oligoethylene glycols induce percolation, medium size polymers increasingly stabilize droplets, and for a degree of polymerization above 200, a regime is reached where percolation is unaffected by changes of chain length. Neutron scattering experiments give evidence that the droplet structure of the microemulsion is maintained when a long-chain PEG is added. We discuss the concentration and molecular weight dependence in terms of an adsorption of polymer at the surfactant interface.
Relaxation of vibrational energy of polyatomic molecules incorporated in a plastic matrix (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRelaxation of vibrational energy of polyatomic molecules incorporated in a plastic matrixA. Seilmeier, J. P. Maier, F. Wondrazek, and W. KaiserCite this: J. Phys. Chem. 1986, 90, 1, 104–108Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://doi.org/10.1021/j100273a024RIGHTS & PERMISSIONSArticle Views42Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (591 KB) Get e-Alerts
Self-consistent<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>G</mml:mi><mml:mi>W</mml:mi></mml:mrow></mml:math>calculations for semiconductors and insulators (2007)

We present $GW$ calculations for small and large gap systems comprising typical semiconductors (Si, SiC, GaAs, GaN, ZnO, ZnS, CdS, and AlP), small gap semiconductors (PbS, PbSe, and PbTe), insulators (C, BN, MgO, and LiF), and noble gas solids (Ar and Ne). It is shown that the ${G}_{0}{W}_{0}$ approximation always yields too small band gaps. To improve agreement with experiment, the eigenvalues in the Green's function $G$ $(G{W}_{0})$ and in the Green's function and the dielectric matrix $(GW)$ are updated until self-consistency is reached. The first approximation leads to excellent agreement with experiment, whereas an update of the eigenvalues in $G$ and $W$ gives too large band gaps for virtually all materials. From a pragmatic point of view, the $G{W}_{0}$ approximation thus seems to be an accurate and still reasonably fast method for predicting quasiparticle energies in simple $sp$-bonded systems. We furthermore observe that the band gaps in materials with shallow $d$ states (GaAs, GaN, and ZnO) are systematically underestimated. We propose that an inaccurate description of the static dielectric properties of these materials is responsible for the underestimation of the band gaps in $G{W}_{0}$, which is itself a result of the incomplete cancellation of the Hartree self-energy within the $d$ shell by local or gradient corrected density functionals.
[Effects of clomiphene and estrogens on circulating gonadotropins, testosterone, androstenedione, in old menopausal women (author's transl)]. (1977)

The threshold of sensitivity of the gonadostat has been tested in 20 old menopausal women by clomiphene (50 or 200 mg/day for 5 days) and/or low doses of ethinyl oestradiol (EE2) (10 or 20 microgram/day). Clomiphene did not increase nor decreased serum levels of LH-FSH and testosterone (T) but increased significantly androstenedione (A) levels. Even at the lower dosage used, EE2 decreased drastically the levels of LH but less completely that of FSH. Clomiphene breaks off partially the oestrogen's blockade on FSH but not on LH. No modification was observed for T and A even after 30 days of estrogen therapy. This data shows the peculiar sensitivity of the gonadostat in advanced menopaused women. It also suggests that the gonadostat exhibits a low threshold of sensitivity analogous to that observed in late prepubertal period. Moreover, the different behaviour of LH and FSH in response to the negative feedback of oestrogens supports that an ovarian factor, distinct from estrogens and missing during menopause plays a role in the regulation of FSH.
Carbohydrate analysis throughout the development of a protein therapeutic (2009)

This review discusses the challenges involved in the characterization of the glycosylation of therapeutic glycoproteins. The focus is on methods that are most commonly used in regulatory filings and lot release testing of therapeutic glycoproteins. The different types of assays for carbohydrate analysis are reviewed, including the distinction between assays appropriate for lot release or better suited to testing during early drug development or in-depth characterization of the glycosylation. Characteristics of the glycoprotein and production process that should be considered when determining the amount of testing, the number of different methods to employ and when the testing should be performed during development of protein therapeutics is also discussed.
Refining Technology Selection (2011)

This chapter contains sections titled: Introduction Hydrotreating Addition and Removal of Oxygen Alkene Conversion Alkane Conversion Residue Conversion Fischer–Tropsch Refining Technology Selection References
Defect-tolerant fpga switch block and connection block with fine-grain redundancy for yield enhancement (2005)

Future process nodes have such small feature sizes that there will be an increase in the number of manufacturing defects per die. For large FPGAs, it will be critical to tolerate multiple defects (Campregher et al., 2005). We propose a number of changes to the detailed routing architecture of island-style FPGAs to tolerate multiple random, distributed interconnect defects without re-routing and with minimal impact on signal timing. Our scheme is a user option prebuilt into an architecture, requiring +11% area for additional multiplexers. Unused (spare) wiring tracks are also needed, bringing total overhead to 24% to tolerate stuck-at or open faults, or 34% to include bridging. User circuits that do not fully stress the routing network already have these tracks freely available. The delay penalty is programmable: 5-10% if defect rates are expected to be sufficiently low, but can be as high as 25% if defect rates are high. Our schemes can tolerate more than 10 interconnect defects for large array sizes of 128 /spl times/ 128. Unlike row/column redundancy schemes, our schemes are scalable: they naturally tolerate more defects as the FPGA array size increases. This work is the first detailed analysis of fine-grained defect-tolerant schemes in FPGAs.
Contrasting Roles for TLR Ligands in HIV-1 Pathogenesis (2010)

The first line of a host's response to various pathogens is triggered by their engagement of cellular pattern recognition receptors (PRRs). Binding of microbial ligands to these receptors leads to the induction of a variety of cellular factors that alter intracellular and extracellular environment and interfere directly or indirectly with the life cycle of the triggering pathogen. Such changes may also affect any coinfecting microbe. Using ligands to Toll-like receptors (TLRs) 5 and 9, we examined their effect on human immunodeficiency virus (HIV)-1 replication in lymphoid tissue ex vivo. We found marked differences in the outcomes of such treatment. While flagellin (TLR5 agonist) treatment enhanced replication of CC chemokine receptor 5 (CCR 5)-tropic and CXC chemokine receptor 4 (CXCR4)-tropic HIV-1, treatment with oligodeoxynucleotide (ODN) M362 (TLR9 agonist) suppressed both viral variants. The differential effects of these TLR ligands on HIV-1 replication correlated with changes in production of CC chemokines CCL3, CCL4, CCL5, and of CXC chemokines CXCL10, and CXCL12 in the ligand-treated HIV-1-infected tissues. The nature and/or magnitude of these changes were dependent on the ligand as well as on the HIV-1 viral strain. Moreover, the tested ligands differed in their ability to induce cellular activation as evaluated by the expression of the cluster of differentiation markers (CD) 25, CD38, CD39, CD69, CD154, and human leukocyte antigen D related (HLA)-DR as well as of a cell proliferation marker, Ki67, and of CCR5. No significant effect of the ligand treatment was observed on apoptosis and cell death/loss in the treated lymphoid tissue ex vivo. Our results suggest that binding of microbial ligands to TLRs is one of the mechanisms that mediate interactions between coinfected microbes and HIV-1 in human tissues. Thus, the engagement of appropriate TLRs by microbial molecules or their mimetic might become a new strategy for HIV therapy or prevention.
Planar 6H-SiC MESFETs with vanadium implanted channel termination (1997)

We use vanadium ion implantation to form a highly resistive surface layer in the wide bandgap semiconductor silicon carbide (SiC). MESFETs are successfully fabricated using this highly resistive layer to isolate gate metal extensions along the channel width from the p-type epilayer. Fabrication and characterization of these devices are described in this paper.
A data model and algebra for the Web (1999)

The recent emergence of XML as a standard for representation and exchange of data on the Web has drawn significant attention. But existing semistructured data models, such as OEM, cannot support XML naturally and fully. A new data model named XOM is proposed in this paper as the common data model for the Web data source. Based on rooted connected directed graphs both cyclic and acyclic, whose nodes are labeled and edges are ranked, XOM can describe the aggregation relationship as well as the general reference relationship (linkage) between XML elements. Through ranked closure operation, both tree-oriented and graph-oriented models can be unified in XOM. As the formal foundation for query processing and optimization for Web data, a new algebra called XOM algebra, which includes six operations, i.e., object union, difference, select, project, paste and cut, is also proposed. In comparison with relational algebra, XOM algebra is more flexible and powerful.