gebhart/patrepeval huggingface dataset:
Hierarchical Paging- Efficient Location Management (2007)

This paper introduces a new location management algorithm called hierarchical paging. A mathematical model for the proposed scheme is also presented. We have compared our solution to two other location management solutions using simulations. The environment, setup, simulation details and results are presented in this paper. It is concluded that there is a wide range of parameters where hierarchical paging is more efficient than the other location management algorithms
Speciation of polonium released from molten lead bismuth (2003)

Abstract The alpha-emitter 210 Po is an activation product of liquid lead-bismuth, a low melting eutectic under investigation as a coolant of the next generation fast nuclear reactors. Experiments were performed to measure the gaseous polonium chemical species for assessing the radioactivity release from a Pb-Bi bath upon contact with a gas stream. The vapor pressure of lead polonide was measured over the 400-550°C temperature range and found to be in agreement with an existing correlation derived from data at higher temperatures. Also, it was experimentally confirmed that the presence of steam in the gas stream above the Pb-Bi melt substantially increases the amount of polonium released due to the formation of the volatile compound H 2 Po. The free-energy variation of the H 2 Po formation reaction was determined, permitting the calculation of the Po gas phase speciation under the experimental conditions.
Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4 <sup>+</sup> T Lymphocytes (2011)

The replication of integrated human immunodeficiency virus type 1 (HIV-1) is dependent on the cellular cofactor cyclin T1, which binds the viral Tat protein and activates the RNA polymerase II transcription of the integrated provirus. The activation of resting CD4(+) T cells upregulates cyclin T1 protein levels independently of an increase in cyclin T1 mRNA levels, suggesting a translational repression of cyclin T1 in resting CD4(+) T cells. Hypothesizing that microRNAs (miRNAs) repress cyclin T1 translation in resting CD4(+) T cells and that this inhibition is lifted upon cell activation, we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation. The overexpression of these miRNAs decreased endogenous cyclin T1 protein levels, while treatment with the corresponding antagomiRs increased cyclin T1 protein levels. An miR-27b binding site within the cyclin T1 3' untranslated region (3'UTR) was identified and confirmed to be functional after the mutation of key resides abrogated the ability of miR-27b to decrease the expression of a luciferase reporter upstream of the cyclin T1 3'UTR. Ago2 immunoprecipitation revealed an association with cyclin T1 mRNA that was decreased following treatment with miR-27b and miR-29b antagomiRs. Cells overexpressing miR-27b showed decreased viral gene expression levels of the HIV-1 reporter virus and a decreased replication of strain NL4.3; a partial rescue of viral transcription could be seen following the transfection of cyclin T1. These results implicate miR-27b as a novel regulator of cyclin T1 protein levels and HIV-1 replication, while miR-29b, miR-223, and miR-150 may regulate cyclin T1 indirectly.
An alternative splice variant of the tissue specific transcription factor HNF4  predominates in undifferentiated murine cell types (1998)

The transcription factor hepatocyte nuclear factor 4α (HNF4α) is a tissue specific transcription factor mainly expressed in the liver, kidney, intestine and the endocrine pancreas, but is also an essential regulator for early embryonic events. Based on its protein structure HNF4α is classified as an orphan member of the nuclear receptor superfamily. Comparing HNF4α transcription factors in the differentiated and dedifferentiated murine hepatocyte cell line MHSV-12 we identified in dedifferentiated cells the novel splice variant HNF4α7. This variant is characterized by an alternative first exon and has a lower transactivation potential in transient transfection assays using HNF4 dependent reporter genes. HNF4α7 mRNA and the corresponding protein are expressed in the undifferentiated pluripotent embryonal carcinoma cell line F9, whereas HNF4α1 only appears after differentiation of F9 cells to visceral endoderm. HNF4α7 mRNA is also found in totipotent embryonic stem cells. However, the function of HNF4α7 seems not to be restricted to embryonic cells as the HNF4α7 mRNA is also present in adult tissues, most notably the stomach. All these features suggest that the presence of distinct splice variants of HNF4α modulates the activity of HNF4α in a cell type specific way.
Squibb Award (1970)

Journal Article Squibb Award Get access Albert B. Sabin Albert B. Sabin Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 121, Issue 3, March 1970, Pages 360–361, https://doi.org/10.1093/infdis/121.3.360 Published: 01 March 1970
ChemInform Abstract: PREPARATION OF SOME BICYCLIC ETHERS (1974)

Abstract 4‐Benzoyloxy‐cyclohexanon (I) liefert mit Cyanessigsäureester das Kondensat (II), das mit Methylmagnesiumjodid in Gegenwart von Cu‐Komplexen zum Addukt (III) reagiert.
Identifying Generalization Properties in Neural Networks (2018)

While it has not yet been proven, empirical evidence suggests that model generalization is related to local properties of the optima which can be described via the Hessian. We connect model generalization with the local property of a solution under the PAC-Bayes paradigm. In particular, we prove that model generalization ability is related to the Hessian, the higher-order "smoothness" terms characterized by the Lipschitz constant of the Hessian, and the scales of the parameters. Guided by the proof, we propose a metric to score the generalization capability of the model, as well as an algorithm that optimizes the perturbed model accordingly.
Intrinsic cell memory reinforces myogenic commitment of pericyte‐derived iPSCs (2010)

Mesoangioblasts (MABs) are a subset of muscle-derived pericytes able to restore dystrophic phenotype in mice and dogs. However, their lifespan is limited and they undergo senescence after 25-30 population doublings. Recently, induced pluripotent stem cells (iPSCs) generated from reprogrammed fibroblasts have been demonstrated to have in vitro and in vivo myogenic potential when sorted for the SM/C-2.6 antigen. Furthermore, chimeric mice from mdx-iPSCs (DYS-HAC) cells showed tissue-specific expression of dystrophin. Nevertheless, myogenic differentiation protocols and the potential of iPSCs generated from different cell sources still present unanswered questions. Here we show that iPSCs generated from prospectively sorted MABs (MAB-iPSCs) are pluripotent as fibroblast-derived iPSCs (f-iPSCs). However, both teratoma formation and genetic cell manipulation assays identify a durable epigenetic memory in MAB-iPSCs, resulting in stronger myogenic commitment. Striated muscle tissue accounts for up to 70% of MAB-iPSC teratomas. Moreover, transfection with Pax3 and Pax7 induces a more robust myogenic differentiation in MAB-iPSCs than in f-iPSCs. A larger amount of CD56(+) progenitors can be sorted from the MAB-iPSCs differentiating pool and, after transplantation into αsg-KO mice, can efficiently participate to skeletal muscle regeneration and restore αsg expression. Our data strongly suggest that iPSCs are a heterogeneous population and, when generated from myogenic adult stem cells, they exhibit a stronger commitment, paving the way for creating custom-made cell protocols for muscular dystrophies.
A pattern-based performance completion for Message-oriented Middleware (2008)

Details about the underlying Message-oriented Middleware (MOM) are essential for accurate performance predictions of software systems using message-based communication. The MOM's configuration and usage strongly influence its throughput, resource utilisation and timing behaviour. Prediction models need to reflect these effects and allow software architects to evaluate the performance influence of MOM configured for their needs. Performance completions [31, 32] provide the general concept to include low-level details of execution environments in abstract performance models. In this paper, we extend the Palladio Component Model (PCM) [4] by a performance completion for Message-oriented Middleware. With our extension to the model, software architects can specify and configure message-based communication using a language based on messaging patterns. For performance evaluation, a model-to-model transformation integrates the low-level details of a MOM into the high-level software architecture model. A case study based on the SPECjms2007 Benchmark [1] predicts the performance of message-based communication with an error less than 20%.
Cinnoline Chemistry. VII. 4-Cinnolinecarboxaldehyde<sup>1,2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCinnoline Chemistry. VII. 4-Cinnolinecarboxaldehyde1,2RAYMOND N. CASTLE and MASAYUKI ONDACite this: J. Org. Chem. 1961, 26, 11, 4465–4469Publication Date (Print):November 1, 1961Publication History Published online1 May 2002Published inissue 1 November 1961https://doi.org/10.1021/jo01069a065RIGHTS & PERMISSIONSArticle Views115Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (614 KB) Get e-Alerts Get e-Alerts
Magnetic properties of Mn1−<i>x</i>M<i>x</i>AlGe (M=3<i>d</i> metals) (1984)

Magnetic measurements are carried out for Mn1−xMxAlGe (M=3d metals) alloys with x up to 0.2. A remarkable increase and decrease of the Curie temperatures with x are observed for M=Cr and Fe, respectively. The substitution of M with x less than 0.1 brings about the reduction in the averaged magnetic moment, which is especially large in the cases of Ti, Fe, and Co and of about 20% for x=0.1. From the measurement of Mössbauer spectrum at 77 K, the internal field at Fe atomic site is not found in Mn0.8Fe0.2AlGe. The reciprocal susceptibility versus temperature curves do not obey the Curie-Weiss law and are concave upward for all the specimens. By adjusting the Curie-Weiss law to the tangents of the highest parts of the χ−1g vs T curves, we obtain values of magnetic moments about 20 (for M=Mn) to 45% (for M=Fe) larger than those obtained from the saturation magnetizations.
Direct ophthalmoscopy in pediatric emergency care (2001)

Thorough knowledge about the basic ophthalmic examination is instrumental in the emergency department (ED) to determine the severity of eye emergencies and to develop a plan for treatment, including the possible need for an ophthalmology consultation. The direct ophthalmoscope is undoubtedly the most practical instrument available to a pediatric emergency physician for ophthalmic examination. However, the information elicited by its use is dependent on the quality of the instrument and the competency of the user. A greater understanding of the range of possibilities of the direct ophthalmoscope as a diagnostic tool will facilitate more efficient care of the pediatric patient.
Ontology-Based Argument Mining and Automatic Essay Scoring (2014)

Essays are frequently used as a medium for teaching and evaluating argumentation skills. Recently, there has been interest in diagrammatic outlining as a replacement to the written outline that often precedes essay writing. This paper presents a preliminary approach for automatically identifying diagram ontology elements in essays, and demonstrates its positive correlation with expert scores of essay quality.
Echo Capsule for Medical Use (A Batteryless Endoradiosonde) (1962)

A new type of a swallowable radio transmitter, ECHO CAPSULE, is described along with some clinical experiments. Unlike other similar capsules which have been reported, this capsule contains no battery and is energized from outside the human body. The energy is converted into dc by the transistor of the oscillator circuit itself, stored into a capacitor and then used as an energy source for the transmission of information on temperature, acidity or the like within the digestive tract.
Speedup Of Data Vortex Network Architecture (2011)

In this paper, 3X3 routing nodes are proposed to provide speedup and parallel processing capability in Data Vortex network architectures. The new design not only significantly improves network throughput and latency, but also eliminates the need for distributive traffic control mechanism originally embedded among nodes and the need for nodal buffering. The cost effectiveness is studied by a comparison study with the previously proposed 2- input buffered networks, and considerable performance enhancement can be achieved with similar or lower cost of hardware. Unlike previous implementation, the network leaves small probability of contention, therefore, the packet drop rate must be kept low for such implementation to be feasible and attractive, and it can be achieved with proper choice of operation conditions.
Open Problem: Better Bounds for Online Logistic Regression (2012)

Known algorithms applied to online logistic regression on a feasible set of L2 diameter D achieve regret bounds like O(e D log T) in one dimension, but we show a bound of O ( √ D + log T) is possible in a binary 1-dimensional problem. Thus, we pose the following question: Is it possible to achieve a regret bound for online logistic regression that is O(poly(D) log(T))? Even if this is not possible in general, it would be interesting to have a bound that reduces to our bound in the one-dimensional case.
Diet-controlled blood levels of oltipraz in healthy male subjects (1984)

The bioavailability of the new antischistosomal agent, oltipraz, was examined under three different dietary conditions in seven healthy males. Oltipraz tablets (500 mg) were administered in single doses (25 mg/kg) under fasting conditions, with a low fat meal (less than 5% fat) and a high fat meal (24% fat). The extent and rate of oltipraz bioavailability were significantly increased by concurrent administration of the drug with food, as demonstrated by the increase in the plasma peak concentration, the area under the plasma concentration vs. time curve and the absorption rate constant. The plasma peak concentration was also reached earlier. Oltipraz plasma concentrations, following its administration under fasting conditions, were almost negligible. The likely mechanisms underlining oltipraz-food interaction are discussed.
The Ketogenic Diet Inhibits Epileptogenesis in EL Mice: A Genetic Model for Idiopathic Epilepsy (2000)

The KD delayed seizure onset in EL mice, suggesting a transient protection against epileptogenesis. The KD did not influence plasma glucose levels or associative learning. Therefore, the EL mouse may serve as a good model to study the antiepileptogenic mechanisms of the KD.
Hypervirulent (hypermucoviscous)<i>Klebsiella pneumoniae</i> (2013)

A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, including liver abscess, pneumonia, meningitis and endophthalmitis and the ability to metastatically spread, an unusual feature for enteric Gram-negative bacilli in the non-immunocompromised. Despite infecting a healthier population, significant morbidity and mortality occurs. Although epidemiologic features are still being defined, colonization, particularly intestinal colonization, appears to be a critical step leading to infection. However the route of entry remains unclear. The majority of cases described to date are in Asians, raising the issue of a genetic predisposition vs. geospecific strain acquisition. The traits that enhance its virulence when compared with "classical" K. pneumoniae are the ability to more efficiently acquire iron and perhaps an increase in capsule production, which confers the hypermucoviscous phenotype. An objective diagnostic test suitable for routine use in the clinical microbiology laboratory is needed. If/when these strains become increasingly resistant to antimicrobials, we will be faced with a frightening clinical scenario.
New Ways of Handling and Running C.R.A. Tubulars Prevent Corrosion in H2S and CO2 Environments (2006)

Abstract In a corrosive downhole environment, the service life of a completion can be severely reduced if no precautions against corrosion are taken. Pipe made of corrosion resistant alloys (C.R.A.) is used to minimize corrosion. An analysis of various corrosion mechanisms shows that the surface integrity is an important factor for corrosion prevention [3]. Conventional spider and elevator inserts as well as conventional hydraulic power tong dies made of steel cause die marks that support corrosion. A gripping system named Micro-Grip distributes the required load equally onto a large number of small peaks, minimizing the indentation of each single peak [1-3]. This system is available for power tongs as well as accessories such as safety clamps. In corrosive downhole environments, such as those that contain relevant quantities of CO2 and/or H2S at elevated temperature, C.R.A. materials with a high chromium content are often selected for the tubular and related accessories. In these environments using C.R.A., companies developed a "zero marking" policy especially for the makeup of the connections. In connection with higher torque values, this required a new gripping technology. A so-called Diamond-Grip gripping system was developed, together with a hydraulic gripping system for the power tong that delivers the required radial forces. The paper describes this new gripping technology and a series of tests that were performed within pre-qualification processes for C.R.A. handling and running tenders in Qatar as well as in the Gulf of Mexico. The tests showed that there is no negative impact of Diamond-Grip and Micro-Grip in regards to corrosion under the severe influence of H2S and CO2.
Error Concealment in the Spectral Domain (1992)

Today's high quality low bitrate coders work on a spectral representation of the audio signal using perceptual noise shaping strategies. Thus, single channel errors affect a block of data in the reconstructed audio signal. Efficient error concealment techniques working in the spectral domain can be employed to avoid annoying error artifacts. A new approach to this problem is developed and first results are presented.
On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures (2008)

We report a novel method for manipulation of single giant DNA molecules under a video microscope. Using optically driven microstructures, we manipulated chromosomal DNA of length in the order of millimetres, extended by electroosmotic flow without DNA breakage in aqueous solution: we picked up DNA, using microfabricated hooks and wound it around microfabricated bobbins.
Real-valued Syntactic Word Vectors (RSV) for Greedy Neural Dependency Parsing (2017)

We show that a set of real-valued word vectors formed by right singular vectors of a transformed co-occurrence matrix are meaningful for determining different types of dependency relations between words.Our experimental results on the task of dependency parsing confirm the superiority of the word vectors to the other sets of word vectors generated by popular methods of word embedding.We also study the effect of using these vectors on the accuracy of dependency parsing in different languages versus using more complex parsing architectures.
Duck Hepatitis B Virus Requires Cholesterol for Endosomal Escape during Virus Entry (2008)

The identity and functionality of biological membranes are determined by cooperative interaction between their lipid and protein constituents. Cholesterol is an important structural lipid that modulates fluidity of biological membranes favoring the formation of detergent-resistant microdomains. In the present study, we evaluated the functional role of cholesterol and lipid rafts for entry of hepatitis B viruses into hepatocytes. We show that the duck hepatitis B virus (DHBV) attaches predominantly to detergent-soluble domains on the plasma membrane. Cholesterol depletion from host membranes and thus disruption of rafts does not affect DHBV infection. In contrast, depletion of cholesterol from the envelope of both DHBV and human HBV strongly reduces virus infectivity. Cholesterol depletion increases the density of viral particles and leads to changes in the ultrastructural appearance of the virus envelope. However, the dual topology of the viral envelope protein L is not significantly impaired. Infectivity and density of viral particles are partially restored upon cholesterol replenishment. Binding and entry of cholesterol-deficient DHBV into hepatocytes are not significantly impaired, in contrast to their release from endosomes. We therefore conclude that viral but not host cholesterol is required for endosomal escape of DHBV.
Trench oxide protection for 10 kV 4H-SiC Trench MOSFETs (2004)

This paper evaluates the use of trench oxide protection on ultra high voltage trench MOSFETs in 4H-SiC. The placement of a p/sup +/ implant under the trench of the MOSFET significantly reduces the peak of the electric field in the trench oxide, thus guarding against premature oxide rupture before reaching the targeted breakdown voltage. Due to this implant, the forward characteristics are severely distorted resulting in a specific on-resistance of 8.6 /spl Omega//spl middot/cm/sup 2/ for the protected UMOSFET compared to 310 m/spl Omega//spl middot/cm/sup 2/ obtained with its unprotected equivalent, for a current density of 50 A/cm/sup 2/. This distortion is due to the JFET effect that arises due to the p/sup +/ implant (and the large difference in doping concentrations of the implant and the voltage blocking layer). Quasisaturation effects in the forward characteristics have also been observed. In addition, for the voltage rating of 10 kV, the electric field in the oxide is much lower that its critical value, and that trench oxide protection is unnecessary for devices with this voltage rating. To guard against possible electric field buildup in the trench corner however, pronounced curvature in the trench corner has been incorporated into the trench MOSFET to improve its performance.