gebhart/patrepeval huggingface dataset:
Oxygen-Free Propane Oxidative Dehydrogenation Over Vanadium Oxide Catalysts: Reactivity and Kinetic Modelling (2013)

Propane conversion to propylene has been the subject of intensive researches. This is due to the increasing demand for propylene. Current propylene production processes suffer from several limitations. Oxidative dehydrogenation (ODH) is a promising alternative technology for propylene production overcoming the drawbacks of current processes. However, selectivity control in ODH is still a challenge preventing it from an industrial application. This is due to the formation of undesired carbon oxides. Thus, the development of a selective catalyst is crucial for the commercialization of ODH. Vanadium oxide catalysts have been proposed as the most active and selective catalyst for propane ODH. Moreover, new reactor concepts such as fluidized-bed might also help to make the ODH a feasible alternative for olefins productionas, offering some outstanding advantages in comparison to conventional reactors.\nThis dissertation provides fundamental understanding of structure-reactivity relationship of vanadium oxide catalyst for propane ODH in a fluidized-bed reactor using the lattice oxygen of vanadium oxide catalysts in the absence of gas-phase oxygen. Supported vanadium oxide catalysts with different vanadium loadings (5-10 wt %) supported on γ-Al2O3 is used. The prepared catalysts are characterized using several techniques such as BET surface area, H2-TPR, NH3-TPD, O2 Chemisorption, Laser Raman Spectroscopy, Pyridine FTIR and XRD. Characterization of the catalysts reveals that monomeric VOx species are predominant at low vanadium loadings while polymeric VOx species increase with higher loadings until monolayer surface coverage is reached. Moreover, the catalysts display moderated acidity compared to that of the bare alumina due to the relative increase in the number of Brønsted acid sites.\nSuccessive-injections propane ODH experiments in the CREC Riser Simulator over partially reduced catalyst show good propane conversions (12%-15%) and promising propylene selectivity (68-86%) at 475-550 0C. Product selectivities are found to augment with the catalyst’s degree of reduction suggesting that a certain degree of catalyst reduction is required for better propylene selectivity. Compared to average propylene yields of 5% and 15% obtained in FCC and steam cracking technologies, respectively, promising value of 7% was obtained in the present propane ODH study over vanadium oxide catalyst and under oxygen free conditions. Such result would encourage further investigation of propane ODH in the absence of molecular gas oxygen as promising alternative/supplementary technology for the production of propylene.\nA kinetic model relating reaction rate to the catalyst’s degree of oxidation is proposed. Non- linear regression leads to model parameters with low confidence intervals, suggesting the adequacy of the proposed model in predicting the ODH reaction under the selected reaction conditions.
Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3. (1992)

IL-3 is a glycoprotein cytokine involved in the hematopoietic response to infectious, immunologic, and inflammatory stimuli. In addition, clinical administration of recombinant IL-3 augments recovery in states of natural and treatment-related marrow failure. IL-3 acts by binding to high affinity cell surface receptors present on hematopoietic cells. To determine the site(s) at which IL-3 binds to it receptor, we analyzed a series of interspecies chimera of the growth factor for species-specific receptor binding and biological activity. The results suggest that IL-3 binds to its receptor and triggers a proliferative stimulus through two noncontiguous helical domains located near the amino terminus and the carboxy terminus of the molecule. To corroborate these findings, we have also mapped the binding epitopes of 10 mAb of human or murine IL-3, and have defined four distinct epitopes. Two of these epitopes comprise the amino-terminal receptor binding domain. A third epitope corresponds to the carboxy-terminal receptor interactive domain, and the fourth epitope, apparently not involved in the interaction of IL-3 and its receptor, lies between these sites. And on the basis of sandwich immunoassays using pairs of these mAbs, the two receptor interactive regions appear to reside in close juxtaposition in the tertiary structure of the molecule. These results provide a correlation of the structure-function relationships of IL-3 that should prove useful in evaluating the details of IL-3-IL-3 receptor interaction and in the rational design of clinically useful derivatives of this growth factor.
Generation of Kidney Cancer-Specific Antitumor Immune Responses Using Peripheral Blood Monocytes Transduced With a Recombinant Adenovirus Encoding Carbonic Anhydrase 9 (2004)

These results suggest that PBMC-derived monocytes transduced with AdV-CA9 can generate RCC-specific MHC class I restricted CTLs capable of lysing CA9-expressing cancer cells. Transduction of PBMC-derived monocytes with adenovirus provides a simple and effective alternative to the use of dendritic cells for the induction of antigen-specific CTL.
Interactive storytelling: interacting with people, environment, and technology (2014)

Stories are an important part of children’s social and cognitive development and can be an integral part of their lives. In this paper, we share a short synopsis of Mobile Stories, one of the narrative systems we have developed with and for children. We also share lessons we have learned while designing, developing, and evaluating Mobile Stories. In designing and developing narrative systems for children, we advocate using iterative co-design (specifically cooperative inquiry). While designing a product, it is important to keep in mind key characteristics of interactive storytelling systems; such systems should encourage and enable creativity, interactivity with the environment via movement and mobility, and interactivity between users. When evaluating interactive storytelling systems, evaluators should consider the different story tasks of reading, creating, and sharing.
Theory of spin-polarized transport in inhomogeneous magnetic semiconductors (2001)

A theory of spin-polarized transport in inhomogeneous magnetic semiconductors is developed and applied to magnetic/nonmagnetic p-n junctions. Several phenomena with possible spintronic applications are predicted, including spinvoltaic effect, spin valve effect, and giant magnetoresistance. It is demonstrated that only nonequilibrium spin can be injected across the space-charge region of a p-n junction, so that there is no spin injection (or extraction) at low bias.
Inhibition of Pancreatic Glucagon Responses to Arginine by Somatostatin in Normal Man and in Insulin-Dependent Diabetics (1974)

Somatostatin, a recently synthesized hypothalamic peptide thought to represent growth hormone-release-inhibiting factor, has been previously shown to inhibit pancreatic glucagon secretion in species other than man. To determine whether somatostatin also inhibits human glucagon secretion, plasma glucagon responses during intravenous infusion of arginine alone (250 mg. per kilogram over twenty-five minutes) and in combination with synthetic cyclic somatostatin (20,μg. per minute) were compared in six normal and six insulin-dependent diabetic subjects. Somatostatin abolished glucagon responses to arginine in both groups, with plasma glucagon declining transiently below basal levels; this occurred despite the fact that the diabetic subjects had fasting hyperglucagonemia and exaggerated glucagon responses during control arginine infusions. In both groups plasma glucose rises seen after arginine were diminished during somatostatin infusions, and, in the normal subjects, insulin responses were also inhibited. These results demonstrate that somatostatin is a potent inhibitor of glucagon secretion in man. Accordingly, it may prove useful as an adjunct to insulin therapy in treatment of insulin-requiring diabetes mellitus.
Microtubule-acting drugs lead to the nonpolarized delivery of the influenza hemagglutinin to the cell surface of polarized Madin-Darby canine kidney cells. (1987)

The synchronized directed transfer of the envelope glycoproteins of the influenza and vesicular stomatitis viruses from the Golgi apparatus to the apical and basolateral surfaces, respectively, of polarized Madin-Darby canine kidney (MDCK) cells can be achieved using temperature-sensitive mutant viruses and appropriate temperature shift protocols (Rindler, M. J., I. E. Ivanov, H. Plesken, and D. D. Sabatini, 1985, J. Cell Biol., 100:136-151). The microtubule-depolymerizing agents colchicine and nocodazole, as well as the microtubule assembly-promoting drug taxol, were found to interfere with the normal polarized delivery and exclusive segregation of hemagglutinin (HA) to the apical surface but not with the delivery and initial accumulation of G on the basolateral surface. Immunofluorescence analysis of permeabilized monolayers of influenza-infected MDCK cells treated with the microtubule-acting drugs demonstrated the presence of substantial amounts of HA protein on both the apical and basolateral surfaces. Moreover, in cells infected with the wild-type influenza virus, particles budded from both surfaces. Viral counts in electron micrographs showed that approximately 40% of the released viral particles accumulated in the intercellular spaces or were trapped between the cell and monolayer and the collagen support as compared to less than 1% on the basolateral surface of untreated infected cells. The effect of the microtubule inhibitors was not a result of a rapid redistribution of glycoprotein molecules initially delivered to the apical surface since a redistribution was not observed when the inhibitors were added to the cells after the HA was permitted to reach the apical surface at the permissive temperature and the synthesis of new HA was inhibited with cycloheximide. The altered segregation of the HA protein that occurs may result from the dispersal of the Golgi apparatus induced by the inhibitors or from the disruption of putative microtubules containing tracks that could direct vesicles from the trans Golgi apparatus to the cell surface. Since the vesicular stomatitis virus G protein is basolaterally segregated even when the Golgi elements are dispersed and hypothetical tracks disrupted, it appears that the two viral envelope glycoproteins are segregated by fundamentally different mechanisms and that the apical surface may be incapable of accepting vesicles carrying the G protein.
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs (2018)

Differentiation of human pluripotent stem cells (hPSCs) into striatal medium spiny neurons (MSNs) promises a cell-based therapy for Huntington's disease. However, clinical-grade MSNs remain unavailable. Here, we developed a chemical recipe named XLSBA to generate clinical-grade MSNs from embryonic stem cells (ESCs). We introduced the γ-secretase inhibitor DAPT into the recipe to accelerate neural differentiation, and replaced protein components with small molecules. Using this optimized protocol we could efficiently direct regular human ESCs (hESCs) as well as clinical-grade hESCs to lateral ganglionic eminence (LGE)-like progenitors and striatal MSNs within less than half of the time than previous protocols (within 14 days and 21 days, respectively). These striatal cells expressed appropriate MSN markers and electrophysiologically acted like authentic MSNs. Upon transplantation into brains of neonatal mice or mouse model of Huntington's disease, they exhibited sufficient safety and reasonable efficacy. Therefore, this quick and highly efficient derivation of MSNs offers unprecedented access to clinical application.
High-power piezoelectric acoustic-electric power feedthru for metal walls (2008)

Piezoelectric acoustic-electric power feed-through devices transfer electric power wirelessly through a solid wall using elastic waves. This approach allows for the elimination of the need for holes through structures for cabling or electrical feed-thrus . The technology supplies power to electric equipment inside sealed containers, vacuum or pressure vessels, etc where holes in the wall are prohibitive or may result in significant performance degradation or requires complex designs. In the our previous work, 100-W of electric power was transferred through a metal wall by a small, piezoelectric device with a simple-structure. To meet requirements of higher power applications, the feasibility to transfer kilowatts level power was investigated. Pre-stressed longitudinal piezoelectric feed-thru devices were analyzed by finite element modeling. An equivalent circuit model was developed to predict the characteristics of power transfer to different electric loads. Based on the analytical results, a prototype device was designed, fabricated and successfully demonstrated to transfer electric power at a level of 1-kW. Methods of minimizing plate wave excitation on the wall were also analyzed. Both model analysis and experimental results are presented in detail in this paper.
Enhanced channel mobility of 4H–SiC metal–oxide–semiconductor transistors fabricated with standard polycrystalline silicon technology and gate-oxide nitridation (2002)

This work presents improved channel mobility of n-channel metal–oxide–semiconductor field-effect transistors (MOSFETs) on 4H–SiC, achieved by gate-oxide nitridation in nitric oxide. Lateral enhancement mode MOSFETs were fabricated using standard polycrystalline silicon gate process and 900 °C annealing for the source and drain contacts. The low field mobility of these MOSFETs was as high as 48 cm2/Vs together with a threshold voltage of 0.6 V, while the interface state density—determined from the subthreshold slope—was about 3×1011 eV−1 cm−2. The 43-nm-thick gate oxide of coprocessed metal–oxide–semiconductor structures exhibited a breakdown field strength of 9 MV/cm.
High-efficiency Voltage-clamped DC-DC converter with reduced reverse-recovery current and switch-Voltage stress (2006)

This paper investigates a high-efficiency clamped-voltage dc-dc converter with reduced reverse-recovery current and switch-voltage stress. In the circuit topology, it is designed by way of the combination of inductor and transformer to increase the corresponding voltage gain. Moreover, one additional inductor provides the reverse-current path of the transformer to enhance the utility rate of magnetic core. In addition, the voltage-clamped technology is used to reduce the switch-voltage stress so that it can select the Schottky diode in the output terminal for alleviating the reverse-recovery current and decreasing the switching and conduction losses. Furthermore, the closed-loop control methodology is utilized in the proposed scheme to overcome the voltage-drift problem of power source under the variation of loads. Thus, the proposed converter topology has a favorable voltage-clamped effect and superior conversion efficiency. Some experimental results via an example of a proton-exchange-membrane fuel cell (PEMFC) power source with a 250-W nominal rating are given to demonstrate the effectiveness of the proposed power-conversion strategy.
Optical thickness monitor for sputtered films (1976)

A modification to a commercial sputtering apparatus to provide real-time monitoring of the optical thickness of sputtered films is described. The design utilizes a small vacuum window in the center of the targets, permitting the passage of a helium–neon laser beam. Modulation of the beam reflectance by the growing sputtered layer permits in situ thickness measurement.
Hybrid Organic–Inorganic Light-Emitting Diodes (1999)

High-efficiency light-emitting diodes (LEDs) using air-stable electrodes remain an important goal. Here the authors report the design and synthesis of electroluminescent hybrid organic–inorganic materials using the sol-gel process in order to improve the aging and environmental stability of LEDs. Devices—which emitted in the orange—consisting of a sol-gel layer sandwiched between a transparent indium tin oxide (ITO) electrode and an evaporated aluminum cathode were also prepared, demonstrating the electroluminescent properties of the sol-gel materials.
Chemistry and Anti-HIV Activity of 2′-β-Fluoro-2′,3′-dideoxyguanosine (1994)

Abstract The 2′-β-fluoro analogue of 2′,3′-dideoxyguanosine has been prepared by two synthetic routes. This compound and two analogues have anti-HIV activity in at least two of three host cell systems used (ATH8, CEM, PBL). These compounds, as well as their ddGuo parents, have been characterized with regard to their acid-stabilities, octanol-water partition coefficients, and enzyme substrate properties for adenosine deaminase and purine nucleoside phosphorylase. F-ddGuo analogues are less potent but more stable than their non-fluorinated parent compounds.
High speed nonvolatile memories employing ferroelectric technology (2003)

The problems encountered in early attempts to build a ferroelectric memory are described. A combination of design innovations and process and materials breakthroughs that can overcome these problems is presented. PZT (lead zirconate titanate) is chosen as the basic ferroelectric material and integrated into a standard CMOS process. PZT has a wide temperature range (+350 degrees C Curie temperature), low coercive voltage, high specific polarization charge (10-20 mu C/cm/sup 2/), and good retention and endurance. The lack of a well-defined coercive field was overcome with a DRAM-like circuit architecture, which provides for transistor switches in series, with each ferroelectric element preventing disturb pulses from affecting the unselected cells. As a demonstration vehicle, a fully decoded 256-b nonvolatile ferroelectric random-access memory (FRAM) was developed. The switching speed inherent in the PZT material was found to be on the order of 1 ns. The high switching speed and the high signal charge, which render the technology highly scalable, offer the potential to build nonvolatile semiconductor memories with the speed of static RAMs and the density and cost of dynamic RAMs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12 (2013)

Our study provided a novel strategy for combined gene therapy that allows constitutive expression of a non-toxic gene such as GM-CSF and heat-induced expression of a toxic gene such as IL-12. In addition, our study also showed that hyperthermia can be used to trigger gene expression in temporal and special manner.
Use of Fluorescence Resonance Energy Transfer for Rapid Detection of Enteroviral Infection In Vivo (2006)

Enteroviruses can be easily transmitted through the fecal-oral route and cause a diverse array of clinical manifestations. Recent outbreaks associated with enteroviral contamination in aquatic environments have called for the development of a more efficient and accurate virus monitoring system. To develop a simple, rapid, and direct method for identifying enteroviral infections, we generated a fluorescent reporter system in which genetically engineered cells express a hybrid fluorescent indicator composed of a linker peptide, which is exclusively cleaved by the 2A protease (2A(pro)), flanked with a cyan fluorescent protein (CFP) and a yellow fluorescent protein undergoing fluorescence resonance energy transfer. The covalent linkage between two fluorophores is disrupted due to 2A(pro) activity upon viral infection, which results in an increase in CFP intensity. This allows the rapid (within 7.5 h) detection of very low numbers (10 PFU or fewer) of infectious enteroviruses.
Vascular and endovascular surgical techniques : an atlas (1994)

Basic principles endovascular procedures transluminal angioplasty and newer intra-arterial techniques extracranial arterial surgery surgery of the aorta, visceral and renal arteries extra-anatomical techniques upper limb lower limb amputations vascular trauma intervention for portal hypertension treatment of varicous vein deep venous surgery.
Semantic annotation tools survey (2013)

The Web has come a long way since its invention by Berners-Lee, when it focused essentially on visualization and presentation of content for human consumption (Syntactic Web), to a Web providing meaningful content, facilitating the integration between people and machines (Semantic Web). This paper presents a survey of different tools that provide the enrichment of the Web with understandable annotation, in order to make its content available and interoperable between systems. We can group Semantic Annotation tools into the diverse dimensions: dynamicity, storage, information extraction process, scalability and customization. The analysis of the different annotation tools shows that (semi-)automatic and automatic systems aren't as efficient as needed without human intervention and will continue to evolve to solve the challenge. Microdata, RDFa and the new HTML5 standard will certainly bring new contributions to this issue.
Adaptive Subspace Symbolization for Content-Based Video Detection (2009)

Efficiently and effectively identifying similar videos is an important and nontrivial problem in content-based video retrieval. This paper proposes a subspace symbolization approach, namely SUDS, for content-based retrieval on very large video databases. The novelty of SUDS is that it explores the data distribution in subspaces to build a visual dictionary with which the videos are processed by deriving the string matching techniques with two-step data simplification. Specifically, we first propose an adaptive approach, called VLP, to extract a series of dominant subspaces of variable lengths from the whole visual feature space without the constraint of dimension consecutiveness. A stable visual dictionary is built by clustering the video keyframes over each dominant subspace. A compact video representation model is developed by transforming each keyframe into a word that is a series of symbols in the dominant subspaces, and further each video into a series of words. Then, we present an innovative similarity measure called CVE, which adopts a complementary information compensation scheme based on the visual features and sequence context of videos. Finally, an efficient two-layered index strategy with a number of query optimizations is proposed to facilitate video retrieval. The experimental results demonstrate the high effectiveness and efficiency of SUDS.