gebhart/patrepeval huggingface dataset:
Use of Dicumarol in Persistent Priapism (1950)

No AccessJournal of Urology1 Aug 1950Use of Dicumarol in Persistent Priapism Keitt H. Smith Keitt H. SmithKeitt H. Smith More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)68648-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1950 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByGoulding F (2018) Priapism Caused by Glucose Phosphate Isomerase DeficiencyJournal of Urology, VOL. 116, NO. 6, (819-820), Online publication date: 1-Dec-1976.Hasen H and Raines S (2018) Priapism Associated with Sickle Cell DiseaseJournal of Urology, VOL. 88, NO. 1, (71-76), Online publication date: 1-Jul-1962. Volume 64Issue 2August 1950Page: 400-402 Advertisement Copyright & Permissions© 1950 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Keitt H. Smith More articles by this author Expand All Advertisement Loading ...
Towards Assume-Guarantee Profiles for Autonomous Vehicles (2019)

Rules or specifications for autonomous vehicles are currently formulated on a case-by-case basis, and put together in a rather ad-hoc fashion. As a step towards eliminating this practice, we propose a systematic procedure for generating a set of supervisory specifications for self-driving cars that are 1) associated with a distributed assume-guarantee structure and 2) characterizable by the notion of consistency and completeness. Besides helping autonomous vehicles make better decisions on the road, the assume-guarantee contract structure also helps address the notion of blame when undesirable events occur. We give several game-theoretic examples to demonstrate applicability of our framework.
Noise Power Spectral Density Estimation on Highly Correlated Data (2006)

In this contribution the Minimum Statistics noise power spectral density estimator [1] is revised for the particular case of highly correlated data which is observed for example when framewise processing with considerable frame overlap is performed. For this special case the noise power estimator tends to underesti-mate the noise power. We identify the variance estimator in the Minimum Statistics approach of being the origin of the observed underestimation. The variance estimator controls the bias com-pensation which is necessary to infer the mean power from a minimum value. This estimator turns out to be biased when the data is correlated. We provide an expression that describes the bias and show that by exploiting this the noise power estimation can be improved. 1.
Time-averaged behaviour of single and dual flying capacitor converters (1989)

The Single Flying Capacitor Converter (SFCC) and Dual Flying Capacitor Converter (DFCC) are two-quadrant power supplies for energy storage and transfer systems. They have applications in nuclear research and pulsed power systems in which superconductive coils are used. In this paper analytical expressions for the time-averaged behaviours of SFCC and DFCC are derived by using averaging technique. Because large superconductive magnet coils are used, time constants of the switched circuits are large enough compared to the switching period. Therefore, an averaged PWM switch equivalent circuit is substituted into the original converter circuits to find the averaged system equations. With this new insight in the averaged dynamics, their design and control can be optimized. Although DFCC has less coil current ripple compared to SFCC, the analysis will show that the averaged behaviours of both converters are the same.
Psoriatic arthritis: clinical response and side effects to methotrexate therapy. (1992)

In the last decade, methotrexate (MTX) has emerged as a useful second line agent for a variety of arthritides. However, there still exists some reluctance for its wider use mainly because of concerns about its liver side effects. We describe our clinical experience with this drug in psoriatic arthritis (PsA). The study group included 24 men and 16 women, with a mean age of 47 years (16-75), with oligoarticular (13) or polyarticular (27) involvement, with a mean disease duration of 12 years (1-36). Patients received a mean dose of 11.2 mg of MTX orally/week during a mean period of 34 months (6-132). Seven had been previously treated with other second line agents. Thirty-eight patients had an excellent or good response. In them, the erythrocyte sedimentation rate dropped in a mean of 38 mm/h. Only 2 patients had a rather poor response. Two patients discontinued the medication because of side effects: leukopenia in one and stomatitis in the other. Eleven patients presented with liver test abnormalities: 3 mild, 6 moderate and 2 severe. Seven patients had 11 liver biopsies. Except for one, none had evidence of cirrhosis or inflammation. Indeed, no changes were observed in the histopathology in those with repeated biopsies. The case reported as cirrhosis occurred very early in the course of MTX therapy. He continued taking MTX treatment without further deterioration of liver chemistry and/or histology. It is concluded that MTX is an effective and safe agent in PsA. Results also indicate that it is not necessary to perform liver biopsies on a routine basis.
ChemInform Abstract: Korbförmige Wirtmoleküle: Tetrahydrofuran‐Einschluß und Gast‐selektive Katalyse des H/D‐Austauschs in saurer Lösung. (1985)

Abstract Man erhält die Hexalactame (IIIa) und (IIIb) durch Verdünnungsprinzip‐Cyclisierung des Hexachlorids (I) mit den Propandiaminen (II).
Towards a miniaturized circulator with magnetic thin film (2007)

This paper takes place in the field of passive microwave components. The requirements of mobile communication devices are today invariably associated with the miniaturization of microwave components. Aimed at this objective, DIOM laboratory (in collaboration with RADIALL Company and INL laboratory) works on the development of a miniature planar circulator. The circulator is designed with coplanar waveguides. The structure is analysed by using a three dimensional finite-element method. As a result, a 9 GHz device with insertion loss of 0.85 dB and isolation of 20.06 dB has been designed.
Abstract DL01-01: Cancer Genomes and their Implications for Early Detection (2013)

Abstract In the past five years, it has become possible to identify all of the mutations contributing to neoplasia in an individual cancer, leading to a deeper understanding of the pathogensis of neoplasia. The challenge now is to exploit this wealth information to reduce cancer deaths. Most current efforts towards this goal are focused on curing patients with advanced disease through “personalized” medicine approaches. However, the barriers to curing such patients are now being recognized, in part through the insights gained from cancer genome sequencing. Alternative strategies to reduce cancer deaths are therefore essential to achieving this goal. Fortunately, it is now clear that there are only ~150 genes, operating through ~12 well-recognized pathways, that drive the initiation and progress of the most common types of human cancers. These genes and pathways provide enormous opportunities for the early detection of neoplasia through sophisticated genomic, proteomic, and imaging-based technologies. Widespread implementation of early detection and prevention methods has the capacity to reduce cancer deaths by more than 75% in the foreseeable future. Citation Format: Bert Vogelstein, Kenneth W. Kinzler. Cancer Genomes and their Implications for Early Detection. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr DL01-01.
CMOS long linear array for space application (2006)

In the past years, it was expected that high-quality scientific imaging would remain out of reach for CMOS sensors since they lacked the required performance in noise, non-uniformity and dark signal levels and hence could not compete with high performances CCDs offering high quantum efficiency, large dynamic range and special modes as Time Delay Integration (TDI) and binning. However, CMOS imaging performs better than expected and allows today to address applications requiring: TDI capability coupled to image acquisition in pushbroom mode in order to enhance radiometric performances, Very long linear arrays thanks to stitching techniques, A high level of on-chip integration with both panchromatic TDI and multispectral linear sensors, On-chip correlated double sampling for low noise operation. This paper presents the design of a CMOS linear array, resulting from collaboration between Alcatel Alenia Space and Cypress Semiconductor, which take advantage of each of these emerging potentialities for CMOS technologies. It has 8000 panchromatic pixels with up to 25 rows used in TDI mode, and 4 lines of 2000 pixels for multispectral imaging. Main system requirements and detector trade-offs are presented, and test results obtained with a first generation prototype are summarized and compared with predicted performances.
Some issues for single address space systems (2002)

We previously described Opal, an OS environment that has a single virtual address space common to all protection domains, rather than the usual private virtual address space per protection domain (e.g., a Unix process). All threads on an Opal node see the same mapping of virtual to physical addresses; any thread can reference any virtual address, but access to the data is determined by the thread's protection domain. The single address space approach is made feasible by the large virtual address spaces of the newest RISC processors. It allows protection domains to pass and share memory segments by mutual consent, while preserving the meaning of pointers. At the time Opal was a paper design, with only a few pieces of implementation. Since that time the key features of Opal have been prototyped. While the current prototype runs on 32-bit MIPS systems, it demonstrates that the model is both workable and useful. Yet the single address space idea remains a difficult adjustment, both conceptually and practically, for those of us long accustomed to per-process address spaces. Having spent much of the past year arguing the benefits of the model, our purpose now is to outline some of its limitations and complications. The goal is to separate the real problems from the false ones, and to focus the debate on the areas that we think are most important, based on our experience.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
COLLOIDAL PLATINUM AND ITS BEHAVIOR AS A TYPICAL ACIDOID SOL (1930)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTCOLLOIDAL PLATINUM AND ITS BEHAVIOR AS A TYPICAL ACIDOID SOLS. W. PennycuickCite this: J. Am. Chem. Soc. 1930, 52, 12, 4621–4635Publication Date (Print):December 1, 1930Publication History Published online1 May 2002Published inissue 1 December 1930https://pubs.acs.org/doi/10.1021/ja01375a001https://doi.org/10.1021/ja01375a001research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wave-equation based traveltime seismic tomography – Part 1: Method (2014)

Abstract. In this paper, we propose a wave-equation based traveltime seismic tomography method with a detailed description of its step-by-step process. First, a linear relationship between the traveltime residual Δt = Tobs – Tsyn and the relative velocity perturbation δc(x) / c(x) connected by a finite-frequency traveltime sensitivity kernel K(x) is theoretically derived using the adjoint method. To accurately calculate the traveltime residual Δt, two automatic arrival-time picking techniques including the envelop energy ratio method and the combined ray and cross-correlation method are then developed to compute the arrival times Tsyn for synthetic seismograms. The arrival times Tobs of observed seismograms are usually determined by manual hand picking in real applications. Traveltime sensitivity kernel K(x) is constructed by convolving a forward wavefield u(t,x) with an adjoint wavefield q(t,x). The calculations of synthetic seismograms and sensitivity kernels rely on forward modelling. To make it computationally feasible for tomographic problems involving a large number of seismic records, the forward problem is solved in the two-dimensional (2-D) vertical plane passing through the source and the receiver by a high-order central difference method. The final model is parameterized on 3-D regular grid (inversion) nodes with variable spacings, while model values on each 2-D forward modelling node are linearly interpolated by the values at its eight surrounding 3-D inversion grid nodes. Finally, the tomographic inverse problem is formulated as a regularized optimization problem, which can be iteratively solved by either the LSQR solver or a non-linear conjugate-gradient method. To provide some insights into future 3-D tomographic inversions, Fréchet kernels for different seismic phases are also demonstrated in this study.
MEASURING CYCLOSPORIN AUC AFTER NEORAL® USING LIMITED SAMPLING - WEIGHTED OR UNWEIGHTED LINEAR REGRESSION? (1999)

Clinical Pharmacology, St Bartholomew's and the Royal London School of Medicine, Charterhouse Square, London, EC1M 6BQ, UK; *Cardiological Sciences, St George's Hospital Medical School, London, UK.
Acute Ischemic Preconditioning of Skeletal Muscle Prior to Flap Elevation Augments Muscle-Flap Survival (1997)

Ischemic preconditioning of the myocardium with repeated brief periods of ischemia and reperfusion prior to prolonged ischemia significantly reduces subsequent myocardial infarction. Following ischemic preconditioning, two "windows of opportunity" (early and late) exist, during which time prolonged ischemia can occur with reduced infarction size. The early window occurs at approximately 4 hours and the late window at 24 hours following ischemic preconditioning of the myocardium. We investigated if ischemic preconditioning of skeletal muscle prior to flap creation improved subsequent flap survival and perfusion immediately or 24 hours following ischemic preconditioning. Currently, no data exist on the utilization of ischemic preconditioning in this fashion. The animal model used was the latissimus dorsi muscle of adult male Sprague-Dawley rats. Animals were assigned to three groups, and the right or left latissimus dorsi muscle was chosen randomly in each animal. Group 1 (n = 12) was the control group, in which the entire latissimus dorsi muscle was elevated acutely without ischemic preconditioning. Group 2 (n = 8) investigated the effects of ischemic preconditioning in the early window. In this group, the latissimus dorsi muscle was elevated immediately following preconditioning. Group 3 (n = 8) investigated the effects of ischemic preconditioning in the late window, with elevation of the latissimus dorsi muscle 24 hours following ischemic preconditioning. The preconditioning regimen used in groups 2 and 3 was two 30-minute episodes of normothermic global ischemia with intervening 10-minute episodes of reperfusion. Latissimus dorsi muscle ischemia was created by occlusion of the thoracodorsal artery and vein and the intercostal perforators, after isolation of the muscle on these vessels. Muscle perfusion was assessed by a laser-Doppler perfusion imager. One week after flap elevation, muscle necrosis was quantified in all groups by means of computer-assisted digital planimetry. Our results show that ischemic preconditioning resulted in a significant reduction (p < 0.05) in muscle-flap necrosis immediately and 24 hours following ischemic preconditioning. Perfusion changes after flap elevation were similar among the three groups. Ischemic preconditioning of skeletal muscle prior to flap creation significantly reduces subsequent muscle-flap necrosis caused by the ischemia of flap creation immediately and 24 hours following ischemic preconditioning. Further elaboration of the mechanisms of ischemic preconditioning may allow pharmacologic preconditioning to be used in the augmentation of skeletal muscle-flap survival in the clinical setting.
Inside BrighamRAD: providing radiology teaching cases on the Internet. (1995)

The Internet provides opportunities for widely distributing educational materials such as teaching files. Since a teaching file is both a tradition and a requirement in an accredited diagnostic radiology training program, many of the same resources can be committed to designing it for Internet access. The advantages include easier availability for the department residents and fellows, communication to a wider audience, the opportunity for networking and collaboration with other institutions during development, and making information available for more rapidly than traditional publications. Since material available on the Internet represents an alternative means of publication, all cases in an electronic teaching file, as is the case with BrighamRad, should be subject to peer review. A successful computer-based teaching file requires department-wide commitment of trainees and staff as well as additional expertise in multimedia instruction, computer-based graphics and design, image manipulation, programming, and database management. Quality efforts take time and require continual adaptation and support as technology and the laws and customs governing the use of electronically published material evolve. The process should be ongoing, and the departmental commitment must be long term and continuous.
Phosphatidylinositol 3-kinase (PI3K) Signaling and Regulation of the Antibody Response (2007)

The humoral immune response is characterized by the early secretion of IgM antibodies followed by the generation of IgG, IgA or IgE antibodies as a result of class switch recombination. In recent years, progress had been made in understanding the molecular events of CSR as well as transcriptional control of B cell differentiation into germinal center or antibody secreting cells. However, the biochemical signals downstream of cell surface receptors that regulate CSR during B cell differentiation remain ill-defined. We have recently identified PI3K as a critical regulator of both antibody secreting cell formation and class switch recombination. How PI3K activity may be regulating CSR during antigen-driven B cell differentiation and its potential contribution to humoral immunodeficiencies will be discussed.
Inhibition of spleen tyrosine kinase in the treatment of rheumatoid arthritis (2013)

The pathogenesis of RA is a complex and ever-changing landscape but amid the chaos of the disease process we have found effective treatment regimes. However, our current therapeutics, although targeting various components of both the innate and adaptive immune response, do not result in disease remission. Protein kinase inhibitors are attractive targets due to their ability to influence downstream signalling and their oral bioavailability. Fostamatinib (R788) inhibits spleen tyrosine kinase (Syk) and has been in clinical trials involving both MTX inadequate responders (MTX-IRs) and biologic inadequate responders. Studies on the MTX-IR population revealed ACR20 responses of 67-72% at higher doses (150 mg bd and 100 mg bd), ACR50 responses of 43-57% and ACR70 responses of 28-40%. The trial in the biologic non-responder population showed no efficacy, however, post hoc analyses of the data suggested that a further trial in this population is warranted. The most common adverse events included gastrointestinal effects, hypertension, neutropenia and transaminitis. Many adverse effects were dose responsive and hypertension was amenable to treatment. Upper respiratory tract infections were more likely at higher doses, but no serious infections with tuberculosis, fungi or opportunistic infections were reported. The oral availability of these agents makes them attractive treatment options for our patients, although the literature from the oncology field suggests that patients will only choose the oral route if efficacy is equivalent. Long-term follow-up studies are ongoing and will be critical for rare side effects. The role of these agents in our current arsenal is unclear and economic analyses are awaited.
Development of a Hybrid Magnetic Resonance and Ultrasound Imaging System (2014)

A system which allows magnetic resonance (MR) and ultrasound (US) image data to be acquired simultaneously has been developed. B-mode and Doppler US were performed inside the bore of a clinical 1.5 T MRI scanner using a clinical 1-4 MHz US transducer with an 8-metre cable. Susceptibility artefacts and RF noise were introduced into MR images by the US imaging system. RF noise was minimised by using aluminium foil to shield the transducer. A study of MR and B-mode US image signal-to-noise ratio (SNR) as a function of transducer-phantom separation was performed using a gel phantom. This revealed that a 4 cm separation between the phantom surface and the transducer was sufficient to minimise the effect of the susceptibility artefact in MR images. MR-US imaging was demonstrated in vivo with the aid of a 2 mm VeroWhite 3D-printed spherical target placed over the thigh muscle of a rat. The target allowed single-point registration of MR and US images in the axial plane to be performed. The system was subsequently demonstrated as a tool for the targeting and visualisation of high intensity focused ultrasound exposure in the rat thigh muscle.
Analysis of Cartilage Tissue on a Cellular Level in Fresh Osteochondral Allograft Retrievals (2007)

Fresh osteochondral allografting is becoming more common in the treatment of articular cartilage defects in the knee. Our findings support the paradigm of fresh osteochondral allografting, the transplantation of hyaline cartilage with biological incorporation of the underlying bone scaffold. The reasons for failure of a small percentage of grafts remain unclear.
Glycerol concentrations required for cryoprotection of 50 typical protein crystallization solutions (1996)

A determination has been made of the glycerol concentration required to form an amorphous glass at 100 K with each of the 50 Crystal Screen I Solutions (Hampton Research, Laguna Hills, California, USA) which form a coarse matrix screen of crystallization conditions for macromolecules. These measurements give a starting point for finding suitable cryoprotectant conditions for protein crystals grown in a wide range of mother liquors.