gebhart/patrepeval huggingface dataset:
<scp>CHILD</scp> Syndrome: Successful Treatment of Skin Lesions with Topical Simvastatin/Cholesterol Ointment—A Case Report (2015)

CHILD syndrome is a rare X-linked dominant condition that presents with congenital hemidysplasia, Ichthyosiform erythroderma, and limb defects in affected patients. We report the case of a 10-year-old girl treated with topical simvastatin and cholesterol ointment, after which her skin lesions significantly improved within the first 30 days of treatment.
Design and Implementation of a New Single-Motor Driven Arm Manipulator (2007)

This paper presents our research work on the design and implementation of a new single-motor driven arm manipulator with multiple independent degrees of freedom. The result of this research work is an arm manipulator consisting of several modular units, each of which has two degrees of freedom: one for twisting rotation and one for pivoting rotation. And, all the degrees of freedom take mechanical energy from the output of a single motor mounted at the base. Compared to the previous prototype developed at the Nanyang Technological University, the work described here has solved the problem of realizing bidirectional motion output at each degree of freedom. In addition to the design work, we will also show some simulation results with the designed arm manipulator.
Methylene blue plus light mediates 8-hydroxy 2'-deoxyguanosine formation in DNA preferentially over strand breakage (1990)

Methylene blue (MB) plus light, in the presence of oxygen, mediates formation of 8-hydroxyguanine in DNA. The yield of 8-hydroxyguanine may be as much as from 2 to 4% of the guanines present. The results presented here show that treatment of supercoiled plasmid DNA with methylene blue plus light causes single-stranded nicks. However, single-stranded nicking occurs approximately 17-fold less frequently than does formation of 8-hydroxyguanine. The nicking rate is reduced in the presence of Mg ion but is not prevented by inhibitors of the iron-catalyzed Fenton reaction or by scavengers of hydroxyl free radicals. Extensive exposure of DNA to light in the presence of MB produces no detectable thiobarbital reactive material thus implicating that single strand nicking does not occur by hydroxyl free radical attack on deoxyribose. Formation of 8-hydroxyguanine is apparently not dependent upon intercalative binding of MB to DNA, since it is formed in polydeoxyguanylic acid.
A Good Bargain: An Inexpensive, Air‐Stable Ruthenium Metathesis Catalyst Derived from α‐Asarone (2003)

Abstract The one‐step synthesis of ruthenium carbene precatalyst 7 from inexpensive α‐asarone [( E )‐ 6 ] is described. This recyclable and easy to obtain complex can be used successfully in various types of metathesis (RCM, CM, enyne) as a cheaper and more potent substitute of the Hoveyda‐type precatalyst 2b . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Optimal temperature policy for immobilized enzyme packed bed reactor performing reversible Michaelis–Menten kinetics using the disjoint policy (2001)

The optimal temperature policy that maximizes the time-averaged productivity of a continuous immobilized enzyme packed bed reactor is determined. This optimization study takes into consideration the enzyme thermal deactivation with substrate protection during the reactor operation. The general case of reversible Michaelis-Menten kinetics under constant reactor feed flow rate is assumed. The corresponding nonlinear optimization problem is solved using the calculus of variations by applying the disjoint policy. This policy reduces the optimization problem into a differential-algebraic system, DAE. This DAE system defines completely the optimal temperature-time profiles. These profiles depend on the kinetic parameters, feed substrate concentration, operating period, and the residence time and are characterized by increasing form with time. Also, general analytical expressions for the slopes of the temperature and residual enzyme activity profiles are derived. An efficient solution algorithm is developed to solve the DAE system, which results into a one-dimensional optimization problem with simple bounds on the initial feed temperature. The enzymatic isomerization of glucose into fructose is selected as a case study. The computed productivities are very close to that obtained by numerical nonlinear optimization with simpler problem to solve. Moreover, the computed conversion profiles are almost constant over 90% of the operating periods, thus producing a homogeneous product.
Missions of a medical school (1999)

Despite its strong reputation and obvious accomplishments, medical education in the United States needs to address five areas in which its products and processes are not sufficiently aligned with society's expectations. First, medical education must address the escalation of health care costs by placing greater emphasis on teaching evidence-based medicine. Second, the current overproduction of medical specialists must be changed in favor of educating generalist physicians. Third, physicians must become more skilled in working with patients and populations to alter poor lifestyle choices. Fourth, medical education should contribute to meeting the health care needs of the medically underserved by ensuring a physician population that is racially and ethnically diverse. Finally, medical education must address the erosion of trust that has occurred between physicians and their patients by emphasizing the primacy of the patient's interest in all that a physician does.
A Locality-Aware Dynamic Thread Scheduler for GPGPUs (2013)

Modern GPGPUs implement on-chip shared cache to better exploit the data reuse of various general purpose applications. Given the massive amount of concurrent threads in a GPGPU, striking the balance between Data Locality and Load Balance has become a critical design concern. To achieve the best performance, the trade-off between these two factors needs to be performed concurrently. This paper proposes a dynamic thread scheduler which co-optimizes both the data locality and load balance on a GPGPU. The proposed approach is evaluated using three applications with various input datasets. The results show that the proposed approach reduces the overall execution cycles by up to 16% when compared with other approaches concerning only one objective.
Design and performance of a few-kilohertz-linewidth dye laser stabilized by reflection in an optical resonator (1988)

Ultrahigh-resolution spectroscopy is limited by the spectral quality of lasers. We describe a servo system that stabilizes a dye laser by reflection in an optical resonator, which provides an error signal. We analyze the error signal to determine the spectral performance of the dye laser, which is shown to have a Gaussian-shaped spectrum with a width of less than 4 kHz.
Electric field effects on a liquid‐crystalline side chain polymer with a negative dielectric anisotropy (1985)

Abstract The behavior of methacrylic side chain polymers in an electric field was observed for a homopolymer ( 1 ) exhibiting a negative dielectric anisotropy compared with a copolymer ( 2 ) of positive dielectric anisotropy. Homopolymer 1 orients spontaneously homeotropic and thus enables the determination of the threshold voltage, rise time and decay time. Based on these experimental results the bend elastic constant and viscosity coefficient were estimated using literature values for the dielectric anisotropy. With respect to the bend elastic constant and electrohydrodynamic effects (e.g. Williams Domains) the homopolymer behaves similarly to low‐molar‐mass liquid crystals, while owing to the high viscosity coefficient response times are large in magnitude.
Surface and Interfacial Structure of Release Coatings for Pressure Sensitive Adhesives I. Polyvinyl N-Alkyl Carbamates (1997)

Abstract Polyvinyl N-alkyl carbamates belong to the general class of long alkyl side chain polymers. Such polymers are commonly used as release coatings for pressure sensitive adhesive tapes. In this paper the bulk, surface, and interfacial structures of polyvinyl N-alkyl carbamates having either decyl or octadecyl side chains are examined. The bulk structures and thermal transitions were characterized using X-ray scattering and differential scanning calorimetry. Dynamic mechanical thermal analysis was used to investigate thermal transitions and rheology (i.e., segmental mobility) of the polyvinyl N-alkyl carbamates. The surface energies of polyvinyl N-alkyl carbamate coatings were determined using contact angle methods, while X-ray photoelectron spectroscopy and static secondary ion mass spectrometry were employed to characterize the near-surface compositional profiles of the coatings. The peel force provided by the polyvinyl N-alkyl carbamate coatings, as a function of aging time and temperature, was measured for a tape having an acrylic acid containing alkyl acrylate based pressure sensitive adhesive. The changes in peel force with aging time and temperature were related to the ability to maintain a stable interfacial structure between the PSA and polyvinyl N-alkyl carbamate coatings. Changes in the interfacial composition upon aging were characterized by comparing the surface compositions of the PSA and polyvinyl N-alkyl carbamate coatings initially, prior to contact, as well as after aging and peeling them apart. The increase in peel force upon aging can be attributed, in large part, to a restructuring at the PSA/polyvinyl alkyl carbamate interface. Energetically favorable acid-base interactions between the basic urethane and acetate groups in the polyvinyl alkyl carbamates and the acrylic acid groups in the PSA provide a driving force for the restructuring. If the segmental mobility within the polyvinyl alkyl carbamate is sufficient, restructuring can occur, leading to increased concentrations of these groups at the PSA/polyvinyl alkyl carbamate interface, resulting in higher attractive forces and greater adhesion. The propensity for the polyvinyl N-alkyl carbamate coatings to restructure upon contact with a polar medium was also characterized by monitoring the receding contact angle of water, as a function of water contact time and temperature. A good correlation is seen between the ability of the polyvinyl alkyl carbamate coatings to provide a low peel force for the acrylate PSA tape and the ability of the coatings to maintain a high water receding contact angle.
Periodical Literature of International Law (1941)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
The halogenation of phenolic ethers and anilides. Part XVII. An investigation into the additive effects of substituents in benzyl phenyl ethers (1955)

B. Jones and E. N. Richardson, J. Chem. Soc., 1955, 2772 DOI: 10.1039/JR9550002772
Hemoglobin-Induced Binding of <i>Candida albicans</i> to the Cell-Binding Domain of Fibronectin Is Independent of the Arg-Gly-Asp Sequence (1998)

Hemoglobin specifically induces fibronectin (FN) binding to the pathogenic yeast Candida albicans. When grown in the complex medium Sabouraud broth, C. albicans expresses receptors that bind to several domains of FN. Growth in defined medium supplemented with 0.1% hemoglobin, however, enhanced the binding of FN to a single class of receptors, with a Kd = 4.6 x 10(-8) M. Competitive binding assays using recombinant and proteolytic fragments of FN revealed that the cell-binding domain mediated this interaction. A recombinant 40-kDa fragment of FN consisting of type III repeats 9 to 13 had an inhibitory activity similar to that of the entire 120-kDa cell-binding domain, indicating that the C-terminal portion of the cell-binding domain contains the binding site. A recombinant 33-kDa fragment of the cell-binding domain and a 33-kDa fragment with the RGD sequence deleted had the same inhibitory activities, demonstrating that the RGD sequence recognized by some mammalian integrins is not required. The addition of hemoglobin to the culture medium also enhanced Candida cell adhesion to immobilized FN and to 120- and 40-kDa fragments of FN but not to the collagen-binding or fibrin I domains. Using ligand protection, we identified a surface protein from C. albicans with an apparent molecular mass of 55 kDa that was protected by both FN and the 40-kDa fragment derived from the cell-binding domain. Therefore, hemoglobin both induces FN binding and changes the relative affinities of C. albicans for the cell- and collagen-binding domains of FN.
Wireline Coring and Analysis under Pressure: Recent Use and Future Developments of the HYACINTH System (2009)

No abstract available. <br><br> doi:<a href="http://dx.doi.org/10.2204/iodp.sd.7.07.2009" target="_blank">10.2204/iodp.sd.7.07.2009</a>
Amphiregulin‐dependent proliferation of cultured human keratinocytes: Autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin‐like glycosaminoglycans (1994)

Amphiregulin, a member of the epidermal growth factor family with heparin binding affinity, functions as a natural regulator of keratinocyte growth. Autocrine signaling by amphiregulin and the effects of exogenous recombinant cytokine were studied in serum-free cultures of human neonatal keratinocytes. A metabolic inhibitor of proteoglycan sulfation was used to assess the role of cellular heparin-like glycosaminoglycans in amphiregulin-dependent growth. Keratinocytes plated at > 10(3) cells/cm2 grew in an autocrine manner in the absence of exogenous epidermal growth factor or amphiregulin. Incubation of keratinocytes with an amphiregulin-blocking antibody indicated that approximately 70% of autocrine growth is mediated by endogenous amphiregulin. Proliferation potential in the presence of recombinant human amphiregulin was dose dependent and saturable and above approximately 1 ng/ml was comparable to that achieved with similar concentrations of epidermal growth factor. Sodium chlorate, which blocks glycosaminoglycan sulfation, reversibly inhibited epidermal growth factor-dependent proliferation by 42%, exogenous amphiregulin-dependent proliferation by 75%, and autocrine growth by 95%; concurrent incubation with 1-100 micrograms/ml heparin partially reversed this inhibition. Exogenous heparin in the absence of chlorate, however, nearly completely inhibited growth under autocrine conditions and in the presence of recombinant amphiregulin. Structure-function studies indicate that the polymerization level, high sulfate group density, and possibly iduronic acid content of heparin-like moieties correlate with their inhibitory activity. Collectively, these observations indicate that amphiregulin is the major autocrine factor for keratinocytes and demonstrate that exogenous amphiregulin is an effective growth promoting factor with molar potency similar to that of epidermal growth factor. Autocrine and paracrine signaling by amphiregulin may require cellular heparin-like glycosaminoglycans, presumably as matrix or membrane proteoglycans, whereas soluble glycosaminoglycans inhibit signaling, possibly by competing for cytokine binding.
Trimethylaminuria: the fish malodor syndrome. (2001)

The fish malodor syndrome (also known as the fish odor syndrome and trimethylaminuria) is a metabolic disorder characterized by the presence of abnormal amounts of the dietary-derived tertiary amine, trimethylamine, in the urine, sweat, expired air, and other bodily secretions. Trimethylamine itself has the powerful aroma of rotting fish, and this confers upon the sufferer a highly objectionable body odor, which can be destructive to the personal, social, and work life of the affected individual. In recent years, much progress has been made at all levels-clinical, epidemiological, biochemical, and genetic-in our understanding of this unfortunate condition. The present article summarizes this progress, draws attention to the different types of fish malodor syndrome, and highlights the current needs in the treatment of such patients.
Device-Free Home Intruder Detection and Alarm System Using Wi-Fi Channel State Information (2016)

In this paper, we design a device-free intruder detection and alarm system, named WiGarde by exploiting off-the-shelf Wi-Fi channel state information (CSI) to detect an intruder through door or window. WiGarde extracts the CSI amplitude information across MIMO antennas. We implemented WiGarde with commercial IEEE 802.11 NICs and evaluated its performance in two cluttered indoor environments. The system is robust and avoids false alarm occurrence, owing to our novel bad stream elimination algorithm. To extract the best feature, we design a new method to intercept the segment of the signal of intrusion based on wavelet analysis and dynamic time window based on Short-time Energy. We adopt Support Vector Machine (SVM) algorithm to classify human intrusion; our SVM algorithm could classify intrusion process with general walking through the area of interest. We compare WiGarde with the previous approaches; results show that our system outperforms the corresponding best CSI-based and RSSI-based in both of static and motion states. Our system gained high accuracy of 94.5% in a dynamic environment for intrusion through door or window.
Report on a visit to the Arvin/Calspan Corporation Buffalo, New York, September 1992 (1993)

The visit to the Arvin Calspan Corporation in Buffalo was made in support of a PhD programme undertaken in the College of Aeronautics (CoA). the research topic concerns flying and handling qualities of advanced fly-by-wire civil aircraft.\n\nWith the introduction of electronic Flight Control Systems (FCS) the responses of aircraft to a pilot input can become highly modified compared with that of conventional aircraft. As such systems have been introduced to military aircraft problems associated with their flying and handling qualities have become apparent. Much research and development work has been undertaken into understanding and solving these problems and producing military aircraft that handle well. Although this work continues, today’s aircraft demonstrate a vast improvement on earlier designs.\n\nWhile much research has been undertaken into the flying and handling qualities of military aircraft considerably less has been performed in the area of civil aircraft. Consequently there are few guidelines for the design, assessment and certification of the civil aircraft now being produced that utilise electronic FCS.\n\nThe purpose of this PhD programme is to address the deficiencies in the civil aircraft field and apply the knowledge and technologies of the military designs and criteria where applicable. In order to do this it is necessary to obtain a thorough understanding of the work undertaken in both the military and civil fields, and to gain exposure to problems that have been identified.\n\nThe Arvin/Calspan Corporation has been involved in handling qualities research since the 1940’s and through it’s numerous research programmes utilising it’s variable stability aircraft has become recognised as one of the world leaders in the field of handling qualities.\n\nTherefore a visit to the headquarters of the Flight Research Department of the Arvin/Calspan Corporation in Buffalo was made in support of this study. The two main purposes were to undertake a literature search of their reports from their research programmes of relevance to this study and to perform an engineering test flight in one of their two Variable Stability Learjet In-Flight Simulators, to demonstrate features of modern FCS designs.\n\nDuring the visit the opportunity was also taken to discuss the more recent developments in the field with Calspan personnel. In addition contact was made with the Stability, Control, Simulation and Flying Qualities Technology Group of the McDonnell Douglas Corporation, Long Beach, who were conducting a TIFS investigation during the visit.
Intraspecies Diversity of <i>Cryptococcus laurentii</i> as Revealed by Sequences of Internal Transcribed Spacer Regions and 28S rRNA Gene and Taxonomic Position of <i>C. laurentii</i> Clinical Isolates (2000)

The intraspecies diversity of an opportunistic yeast pathogen, Cryptococcus laurentii, was revealed by analysis of the sequences of the internal transcribed spacer regions and the 28S rRNA gene. Ten strains of C. laurentii were grouped into two major phylogenetic groups and were further divided into at least seven species. Four of the strains isolated from patients did not represent a single species but showed heterogeneity. These results suggest that C. laurentii is a genetically heterogeneous species, and this must be taken into consideration when identifying C. laurentii clinical isolates.
Fast penetration depth computation for physically-based animation (2002)

We present a novel and fast algorithm to compute penetration depth (PD) between two polyhedral models for physically-based animation. Given two overlapping polyhedra, it computes the minimal translation distance to separate them using a combination of object-space and image-space techniques. The algorithm computes pairwise Minkowski sums of decomposed convex pieces and performs a closest point query using rasterization hardware. It uses bounding volume hierarchies, object-space and image-space culling algorithms to further accelerate the computation and refines the estimated PD in a hierarchical manner. We demonstrate its application to contact response computation and a time-stepping method for dynamic simulation.
Effect of nickel particle size on alumina supported nickel catalysts for p-nitrophenol hydrogenation (2007)

The catalytic hydrogenation of p-nitrophenol to p-aminophenol was investigated over alumina supported nickel catalysts prepared by impregnation reduction method and mechanical mixing method. The catalysts were characterized by XRD and FESEM. The results show that the nickel particle diameter of alumina supported nickel prepared by impregnation reduction method (denoted as Ni/Al 2 O 3 ) is slightly smaller than that of alumina supported nickel prepared by mechanical mixing method (denoted as Ni+Al 2 O 3 ), and the catalytic activity of Ni/Al 2 O 3 is higher. The nickel particle size of Ni/Al 2 O 3 would increase as Ni/Al 2 O 3 is reduced in hydrogen for 2 h at 270 °C and 600 °C, respectively, and its catalytic activity correspondingly decreases. These imply that the reaction is structure sensitive and the smaller nickel particle diameter is beneficial to obtain a higher catalytic activity. However, the nickel particle diameter almost has no influence on the catalytic selectivity of the p-nitrophenol hydrogenation to p-aminophenol.