gebhart/patrepeval huggingface dataset:
A study of pressure pulses generated by travelling bubble cavitation (1993)

The collapse process of single bubbles in travelling bubble cavitation around two axisymmetric headforms have been studied acoustically to understand the collapse process of a cavitation bubble and characterize the sound emission in travelling bubble cavitation. The bubbles were observed to collapse and then sometimes to rebound and collapse again, resulting in one or two pulses in the acoustic signal from a cavitation event. It was observed that each of the pulses could contain more than one peak. This phenomenon is called multipeaking and is clearly distinct from rebounding. The occurrence of rebounding and multipeaking and their effects on some characteristic measures of the acoustic signal such as power spectra are examined in this paper. Two particular headforms (ITTC and Schiebe) with distinct flow characteristics were investigated. Both rebounding and multipeaking increased with reduction in the cavitation number for the ITTC headform. Smaller flow velocity, smaller cavitation number and multipeaking delay the rebound. The peak amplitude of the sound emitted from the first collapse was seen to be twice as large as the peak amplitude of sound from the second collapse, suggesting a repeatable process of bubble fission during the collapse process. Multipeaking and rebounding increased the characteristic measures of the acoustic signal such as the acoustic impulse. These characteristic measures have larger magnitudes for smaller flow velocity. Also, the values of these characteristics are larger for the ITTC headform than for Schiebe headform. Theoretical calculations based on the Rayleigh–Plesset equation were seen to correctly predict the order of magnitude of most of these characteristic measures. However, the distribution of spectral energy is not properly predicted; bubble fission during the collapse is thought to account for this discrepancy. Reduction in the cavitation number and multipeaking are observed to decrease the fraction of spectral energy contained in the high-frequency range (30–80 kHz).
Quasi-dielectrically isolated bipolar junction transistor with sub-collector fabricated using silicon selective epitaxy (2002)

A quasi-dielectrically isolated bipolar junction transistor (QDI-BJT) was developed for intelligent power ICs. Using a combination of junction and dielectric isolation, the QDI-BJT was achieved by selective epitaxial growth (SEG) of single-crystal silicon in an oxide lined trench. Buried collectors formed by ion implantation and in-situ doped SEG silicon drastically reduce collector resistance while having no detrimental effects on transistor performance. The emitter-base and collector-base ideality factors at 1.10 and 1.09, respectively, were very close to those of similar devices fabricated in the substrate in the same die, indicating the excellent crystal quality of the SEG silicon. Due to the use of a trench structure to facilitate isolation and control of the SEG thickness, the QDI process can be used for any application where the thickness and resistivity of the control and power areas are independently optimized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Soviet Russia in the Second Decade: A Joint Survey by the Technical Staff of the First American Trade Union Delegation. (1929)

Journal Article Soviet Russia in the Second Decade: a Joint Survey by the Technical Staff of the First American Trade Union Delegation Get access Soviet Russia in the Second Decade: a Joint Survey by the Technical Staff of the First American Trade Union Delegation. By R. G. Tugwell, S. Chase and R. Dunn. 1929. (London: Williams and Norgate. 8vo. xiii + 374 pp. 16s.) M. Philips Price M. Philips Price Search for other works by this author on: Oxford Academic Google Scholar Journal of the Royal Institute of International Affairs, Volume 8, Issue 2, March 1929, Pages 176–178, https://doi.org/10.2307/3015136 Published: 01 March 1929
Mesh Adaptive Direct Search Algorithms for Constrained Optimization (2006)

This paper addresses the problem of minimization of a nonsmooth function under general nonsmooth constraints when no derivatives of the objective or constraint functions are available. We introduce the mesh adaptive direct search (MADS) class of algorithms which extends the generalized pattern search (GPS) class by allowing local exploration, called polling, in an asymptotically dense set of directions in the space of optimization variables. This means that under certain hypotheses, including a weak constraint qualification due to Rockafellar, MADS can treat constraints by the extreme barrier approach of setting the objective to infinity for infeasible points and treating the problem as unconstrained. The main GPS convergence result is to identify limit points $\hat{x}$, where the Clarke generalized derivatives are nonnegative in a finite set of directions, called refining directions. Although in the unconstrained case, nonnegative combinations of these directions span the whole space, the fact that there can only be finitely many GPS refining directions limits rigorous justification of the barrier approach to finitely many linear constraints for GPS. The main result of this paper is that the general MADS framework is flexible enough to allow the generation of an asymptotically dense set of refining directions along which the Clarke derivatives are nonnegative. We propose an instance of MADS for which the refining directions are dense in the hypertangent cone at $\hat{x}$ with probability 1 whenever the iterates associated with the refining directions converge to a single $\hat{x}$. The instance of MADS is compared to versions of GPS on some test problems. We also illustrate the limitation of our results with examples. An erratum to this article has been appended at the end of the pdf file.
Influence of cell surface hydrophobicity on attachment of<i>Candida albicans</i>to extracellular matrix proteins (1995)

Cell surface hydrophobicity expression by Candida albicans facilitates a diffuse binding distribution of yeast cells to host tissues ex vivo. One possibility for the receptor site responsible for the binding pattern of hydrophobic cells is the extracellular matrix (ECM). In this study, we evaluated the interaction of hydrophobic and hydrophilic C. albicans with ECM proteins immobilized onto wells of microtitre tissue. Culture plates, and the ability of ECM proteins to block the binding of hydrophobic cells to splenic tissue ex vivo. Hydrophobic C. albicans bound in greater numbers than hydrophilic cells to the immobilized proteins, particularly fibrinogen, fibronectin, collagen type IV and laminin. Similar results were obtained regardless of C. albicans strains or of growth medium. Collagen and fibronectin blocked the binding of hydrophobic cells to the white pulp but not to the marginal zones in splenic tissues when tested with the ex vivo assay. These results suggests that the diffuse binding pattern of hydrophobic cells in the ex vivo assay may be due to their enhanced ability over hydrophilic cells to bind to ECM proteins, particularly fibronectin and collagen type IV.
Simultaneous sensing and actuation using piezoelectric materials (1992)

The possibility of using a single piezoelectric element simultaneously as both a structural actuator and collocated sensor is investigated. The coupled actuator and sensor equations for an arbitrary elastic structure with piezoelectric elements are developed using an assumed modes energy method. Examination of these equations suggests a simple implementation of collocated strain or strain rate sensing using a voltage driven piezoelectric element. The properties of such a collocated strain or strain rate sensor are presented. The general equations are applied to the case of a cantilevered beam with surface mounted piezoceramics. The theoretical derivations are validated experimentally on an actively controlled cantilevered beam test article with a single piezoelectric element used for collocated strain rate feedback.
Synthesis of DNA complementary to the mRNAs for milk proteins by E.coli DNA polymerase I. (1976)

E.Coli DNA polymerase I (Klenow subfragment) was used for the synthesis of complementary DNA with the mRNAs for rabbit milk proteins as templates. The cDNA formed, contained 200 nucleotides and represented about 20% of the mRNA template. The cDNA was hybridized specifically to the mRNA templates. The Klenow subfragment of the E.Coli DNA polymerase I was as efficient as the avian myeloblastosis virus reverse transcriptase in the synthesis of cDNA. The mean size of the cDNA fragments obtained with the Klenow enzyme proved to be 70% of the value obtained with the AMV reverse transcriptase and at least twice the value generally obtained with the complete E.Coli DNA polymerase I. The cDNA was used for the detection and the quantification of the mRNA template in various RNA fractions.
Disk scheduling in a multimedia I/O system (2005)

This article provides a retrospective of our original paper by the same title in the Proceedings of the First ACM Conference on Multimedia, published in 1993. This article examines the problem of disk scheduling in a multimedia I/O system. In a multimedia server, the disk requests may have constant data rate requirements and need guaranteed service. We propose a new scheduling algorithm, SCAN-EDF, that combines the features of SCAN type of seek optimizing algorithm with an Earliest Deadline First (EDF) type of real-time scheduling algorithm. We compare SCAN-EDF with other scheduling strategies and show that SCAN-EDF combines the best features of both SCAN and EDF. We also investigate the impact of buffer space on the maximum number of video streams that can be supported.We show that by making the deadlines larger than the request periods, a larger number of streams can be supported.We also describe how we extended the SCAN-EDF algorithm in the PRISM multimedia architecture. PRISM is an integrated multimedia server, designed to satisfy the QOS requirements of multiple classes of requests. Our experience in implementing the extended SCAN-EDF algorithm in a generic operating system is discussed and performance metrics and results are presented to illustrate how the SCAN-EDF extensions and implementation strategies have succeeded in meeting the QOS requirements of different classes of requests.
Targeting Autophagy in Cancer: Recent Advances and Future Directions (2019)

Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit the growth of established tumors and improve response to cancer therapeutics. Certain cancer genotypes may be especially prone to autophagy inhibition. Different strategies for autophagy modulation may be needed depending on the cancer context. Here, we review new advances in the molecular control of autophagy, the role of selective autophagy in cancer, and the role of autophagy within the tumor microenvironment and tumor immunity. We also highlight clinical efforts to repurpose lysosomal inhibitors, such as hydroxychloroquine, as anticancer agents that block autophagy, as well as the development of more potent and specific autophagy inhibitors for cancer treatment, and review future directions for autophagy research. SIGNIFICANCE: Autophagy plays a complex role in cancer, but autophagy inhibition may be an effective therapeutic strategy in advanced cancer. A deeper understanding of autophagy within the tumor microenvironment has enabled the development of novel inhibitors and clinical trial strategies. Challenges and opportunities remain to identify patients most likely to benefit from this approach.
Ion Emission from a Beam-Plasma Discharge (1971)

The mammalian cochlea contains a population of outer hair cells (OHCs) whose electromotility depends on an assembly of 'motor' molecules in the basolateral membrane of the cell. Named 'prestin', the molecule is a member of the SLC26 anion transporter superfamily. We show both directly and indirectly that SLC26A5, rat prestin, takes up hexoses when expressed in several cell lines. Direct measurements of labelled fructose transport into COS-7 cells expressing prestin are reported here. Indirect measurements, using imaging techniques, show that transfected HEK-293 or CHO-Ki cells undergo reversible volume changes when exposed to isosmotic glucose-fructose exchange. The observations are consistent with the sugar transport. A similar transport was observed using a C-terminal green fluorescent protein (GFP)-tagged pendrin (SLC26A4) construct. Cells transfected with GFP alone did not respond to sugars. The data are consistent with fructose being transported by prestin with an apparent Km=24 nm. From the voltage-dependent capacitance of transfected cells, we estimate that 250,000 prestin molecules were present and hence that the single transport rate is not more than 3000 fructose molecules s(-1). Comparison of the transfected cell swelling rates induced by fructose and by osmotic steps indicates that water was co-transported with sugar. We suggest that the structure of SLC26 family members allows them to act as neutral substrate transporters and may explain observed properties of cochlear hair cells.
Macrocephaly with hamartomas: Bannayan‐Zonana syndrome (1984)

Familial macrocephaly with mesodermal hamartomas is described as a distinct syndrome in nine individuals from four families. Constant manifestations include symmetrical macrocephaly without ventricular enlargement, mild neurological dysfunction, and postnatal growth deceleration. Speech and motor delays observed in all the children were usually well compensated by adulthood. Two children had mild mental retardation and seizures which may have been related to intracerebral hemorrhage in one. Mesodermal hamartomas were present in affected persons from all four families, with 60% of individuals manifesting only discrete lipomas and hemangiomas. More serious tumors, including intracerebral hemangiomas, hemangiomatous involvement of the bone, and aggressive lipomas occurred in 40%. Other findings that make it possible to delineate a recognizable syndrome include down-slanting palpebral fissures (66%), a high palate (67%), joint hyperextensibility (55%), pectus excavatum (22%), strabismus or amblyopia (33%), and prolonged drooling (44%). The Bannayan-Zonana syndrome is an autosomal-dominant trait with male predominance of affected individuals.
Dynamic Spectrum Management (DSM) Algorithms for Multi-User xDSL (2010)

Dynamic Spectrum Management (DSM) is an effective method for reducing the effect of crosstalk in Digital Subscriber Line (DSL) systems. This paper discusses various DSM algorithms, including Optimal Spectrum Balancing (OSB), Iterative Spectrum Balancing (ISB), Autonomous Spectrum Balancing (ASB), Iterative Water-Filling (IWF), Selective Iterative Water-filling (SIW), Successive Convex Approximation for Low complExity (SCALE), the Difference of Convex functions Algorithm (DCA), and Distributed Spectrum Balancing (DSB). They are compared in terms of performance (achievable data rate) and computational complexity.
Detection of <i>Escherichia coli</i> and <i>Salmonella typhimurium</i> Using Interdigitated Microelectrode Capacitive Immunosensors: The Importance of Transducer Geometry (2008)

This paper presents an immunosensing system to detect Escherichia coli and Salmonella based on electrochemical impedance spectroscopy at interdigitated electrode structures. Our results show the importance of good electrode design in the final detection limit. Four different structures have been fabricated and functionalized. Biotinylated polyclonal antibodies have been immobilized on neutravidin-coated chips, and BSA has been used to avoid nonspecific adsorption. The immunosensor may be said to be capacitive since it is that part of the impedance used to monitor the presence of bacteria in phosphate buffer solution samples. Detection limits around 10(4)-10(5) cells mL(-1) have been reached using chips featuring interdigitated structures of less than 10 microm wide and 1.5 mm long. In both cases, the detection limits of the corresponding ELISA assays, using the same antibodies, was 1 order of magnitude higher (10(5)-10(6) cells mL(-1)). The analysis time, including sensor preparation was less than 5 h.
How to migrate legacy systems from mainframe to open systems technology (1994)

It is widely acknowledged that it is the legacy systems which are preventing most organisations from moving from mainframe technology to open systems technology. A legacy system tends to be a system which has been run by an organisation for upwards of 10 years and has acquired its name by being handed down. You may not have the original documentation, and it may be difficult to maintain and enhance, but it has probably taken many years to write, is essential to the smooth running of the business. The author discusses how to migrate these legacy systems from mainframe to open system technology. He considers a set of tools from Legacy Software Downsizing Ltd of Manchester, called Powerdrive, to automate the migration of legacy systems to Unix relational database.
Expression in animal cells of the 5‐HT<sub>1A</sub> receptor by a vaccinia virus vector system (1992)

The co-infection or infection-transfection variants of the T7 RNA polymerase/vaccinia vector system were used to express 5-HT1ARs in COS-7, BSC-40 and GH3 cells, with co-infection giving ca. 3-fold higher level than infection-transfection. Binding affinities were similar to those of the endogenous 5-HT1AR, with highest affinities for 5-HT and 8-OH-DPAT. Functional properties were demonstrated by assays of agonist-stimulated GTPase activity and its inhibition by pertussin toxin. Immunoblot assays showed expression of the unglycosylated and glycosylated receptor protein in the membrane and, surprisingly, in the cytosolic fractions.
Biometrics verification in a real environment (2003)

This paper describes some of the biometrics verification applications developed within the project ACTS-102 M2VTS: multimodal verification for teleservices and applications. These prototypes provide identity authentication in two of the most promising application areas of biometrics: Secured access to financial services (ATM and Internet Teleservices) and building security applications. The verification modalities implemented into the prototypes are face and speech verification, these are potentially the best accepted by users since they are the less intrusive and the more inexpensive. To achieve higher levels of security, the results obtained by each modality are combined using a fusion method, which decides the user acceptance or rejection. Every prototype has been tested by end-users in a close to real environment.
A salt-rejecting floating solar still for low-cost desalination (2018)

A floating, low-cost solar desalination system was constructed, capable of simultaneous salt rejection and heat localization for continuous operation.
Fabrication of Silicon Field Emitter Arrays Integrated with Beam Focusing Lens (1996)

A new field emitter structure capable of generating a focused electron beam (FEB) was fabricated. The present structure is basically similar to a double-gated structure, however, the two gate openings are arranged in the same way as a confocal in-plane lens structure. The inner gate acts as an extraction gate with a 0.6-µm-diameter opening and the outer one acts as an electrostatic focusing lens with a 2.4-µm-diameter opening. The field emission characteristics were evaluated and a beam current of 70 nA/tip was obtained when a bias voltage of 70 V was applied to the two gates. The beam focusing characteristics were also evaluated and the beam could be focused by decreasing the focusing lens voltage without a significant decrease in the beam current.
UV-absorbance profile of human leukocytic ultrafiltrate after affinity chromatography on immobilized m-aminophenyl boronic acid: implication for transfer factor purification. (1985)

The UV-absorbance of the lysed human leukocyte ultrafiltrate (LLU) was investigated by Sephadex G-15 gel permeation chromatography before and after affinity chromatography on immobilized m-aminophenyl boronic acid. This biospecific fractionation caused substantial changes in 260/280-nm absorbance ratio of individual peaks as revealed by Sephadex G-15 gel permeation chromatography. While the material which had passed through the affinity support unretarded (W) appeared to be partly or completely deprived of peak IV, peaks IV and V were fairly enriched in the retarded material (R). This material, on the other hand, nearly completely missed peaks III, VI and VII. Peak III was copiously represented in material W. Boronate affinity chromatography caused enrichment in the protein content as well as in the content of purine/pyrimidine-bound ribose of material R, i.e. cis-diol group containing (RNA-like) material, considered to represent functional transfer factor activity. The described findings further support the use of immobilized derivatives of boronic acid in the separation of coplanar cis-diol group containing compounds from other constituents of LLU.
Hug over a distance (2005)

People in close relationships, who are separated by distance, often have difficulty expressing intimacy adequately. Based on the results of an ethnographic study with couples, a prototype was developed to test the feasibility of technology in the domain of intimacy. Hug Over a Distance is an air-inflatable vest that can be remotely triggered to create a sensation resembling a hug. Although the couples did not consider the vest to be useful in their daily lives, the prototype served to provoke and stimulate design ideas from the couples during participative design workshops. An additional and unexpected benefit was also found: the prototype enhanced the couples' understanding of the researchers' methods, suggesting that prototypes can serve as tools to make participatory design volunteers aware of their importance in academic research.
Polarized Cell Motility: Microtubules Show the Way (2004)

This chapter contains sections titled: Introduction The Vasiliev Conundrum Cell Polarity and Adhesion Microtubules Meet the Actin Cytoskeleton at Focal Adhesions Microtubule Targeting Promotes Focal Adhesion Turnover Contractility, the Functional Link Kinesin and Signal Transmission Tip Complexes Meet Adhesion Complexes Focal Adhesions Influence Microtubule Dynamic Actin Talks Back: Tension and Microtubule Guidance Conclusions and Perspectives Acknowledgments References
The Medicinal Potential of Promising Marine Macrolides with Anticancer Activity (2011)

Marine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various molecular targets. In particular, the marine macrolides, which include an array of novel biomolecules endowed with outstanding cytotoxic and/or antiproliferative activities, are a prominent class of marine natural products that offer continued promise for breakthroughs in anticancer research. Herein we highlight some recent studies of promising marine macrolides, paying particular attention to their discovery, anticancer activities, mechanisms of action, chemical synthesis, and representative analogues.