gebhart/patrepeval huggingface dataset:
Difluoromethylornithine therapy of female NZB/W mice. (1991)

We studied the effects of difluoromethylornithine (DFMO), an experimental drug that inhibits the biosynthesis of natural polyamines, on anti-DNA antibody production, immunoglobulin synthesis, proteinuria, and blood urea nitrogen (BUN) in lupus-prone female NZB/W mice. Administration of 1% of the drug in drinking water reduced anti-DNA antibody levels by about 80% of that of untreated mice of the same strain. There was a reduction of IgG and IgA levels in older DFMO treated mice, whereas IgM level was not affected. Proteinuria and BUN were also significantly reduced in treated mice. Moreover, DFMO treatment reduced the concentration of putrescine and spermidine in spleen cells. Our results suggest that polyamine biosynthesis inhibition by DFMO may provide a new approach to the treatment of lupus.
Surveyors' forum: Notations for concurrent programming (1983)

article Free Access Share on Surveyors' forum: Notations for concurrent programming Authors: Gregory R. Andrews Department of Computer Science, University of Arizona, Tucson, Arizona Department of Computer Science, University of Arizona, Tucson, ArizonaView Profile , Fred B. Schneider Department of Computer Science, Cornell University, Ithaca, New York Department of Computer Science, Cornell University, Ithaca, New YorkView Profile Authors Info & Claims ACM Computing SurveysVolume 15Issue 4December 1983 pp 376–377https://doi.org/10.1145/289.357842Online:02 December 1983Publication History 0citation326DownloadsMetricsTotal Citations0Total Downloads326Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Rapid High-Throughput Assessment of Aerobic Bacteria in Complex Samples by Fluorescence-Based Oxygen Respirometry (2006)

A simple method has been developed for the analysis of aerobic bacteria in complex samples such as broth and food homogenates. It employs commercial phosphorescent oxygen-sensitive probes to monitor oxygen consumption of samples containing bacteria using standard microtiter plates and fluorescence plate readers. As bacteria grow in aqueous medium, at certain points they begin to deplete dissolved oxygen, which is seen as an increase in probe fluorescence above baseline signal. The time required to reach threshold signal is used to either enumerate bacteria based on a predetermined calibration or to assess the effects of various effectors on the growth of test bacteria by comparison with an untreated control. This method allows for the sensitive (down to a single cell), rapid (0.5 to 12 h) enumeration of aerobic bacteria without the need to conduct lengthy (48 to 72 h) and tedious colony counts on agar plates. It also allows for screening a wide range of chemical and environmental samples for their toxicity. These assays have been validated with different bacteria, including Escherichia coli, Micrococcus luteus, and Pseudomonas fluorescens, with the enumeration of total viable counts in broth and industrial food samples (packaged ham, chicken, and mince meat), and comparison with established agar plating and optical-density-at-600-nm assays has been given.
Supervised Learning with Quantum-Inspired Tensor Networks (2016)

Tensor networks are efficient representations of high-dimensional tensors which have been very successful for physics and mathematics applications. We demonstrate how algorithms for optimizing such networks can be adapted to supervised learning tasks by using matrix product states (tensor trains) to parameterize models for classifying images. For the MNIST data set we obtain less than 1% test set classification error. We discuss how the tensor network form imparts additional structure to the learned model and suggest a possible generative interpretation.
Preparation of layered diacetylenes as a demonstration of strategies for supramolecular synthesis. (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of layered diacetylenes as a demonstration of strategies for supramolecular synthesis.John J. Kane, Ruey-Fen Liao, Joseph W. Lauher, and Frank W. FowlerCite this: J. Am. Chem. Soc. 1995, 117, 48, 12003–12004Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://doi.org/10.1021/ja00153a026RIGHTS & PERMISSIONSArticle Views715Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (767 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review (2018)

Ageing is inevitable. Recent studies suggest that it could be delayed. Low-grade systemic inflammation is seen in type 2 diabetes mellitus, hypertension and endothelial dysfunction that are common with increasing age. In all these conditions, an alteration in arachidonic acid (AA) metabolism is seen in the form of increased formation of pro-inflammatory eicosanoids and decreased production of anti-inflammatory lipoxins, resolvins, protectins and maresins and decreased activity of desaturases. Calorie restriction, exercise and parabiosis delay age-related changes that could be related to enhanced proliferation of stem cells, decrease in inflammation and transfer of GDF-11 (growth differentiation factor-11) and other related molecules from the young to the old, increase in the formation of lipoxin A4, resolvins, protectins and maresins, hydrogen sulfide (H<sub>2</sub>S) and nitric oxide (NO); inhibition of ageing-related hypothalamic or brain IKK-β and NF-kB activation, decreased gonadotropin-releasing hormone (GnRH) release resulting in increased neurogenesis and consequent decelerated ageing. This suggests that hypothalamus participates in ageing process. N-acylethanolamines (NAEs) and lipid-derived signalling molecules can be tuned favorably under dietary restriction to extend lifespan and/or prevent advanced age associated diseases in an mTOR dependent pathway manner. Sulfur amino acid (SAA) restriction increased hydrogen sulfide (H<sub>2</sub>S) production and protected tissues from hypoxia and tissue damage. Anti-inflammatory metabolites formed from AA such as LXA4, resolvins, protectins and maresins enhance production of NO, CO, H<sub>2</sub>S; suppress NF-kB expression and alter mTOR expression and thus, may aid in delaying ageing process. Dietary restriction and exercise enhance AA metabolism to form LXA4, resolvins, protectins and maresins that have anti-inflammatory actions. AA and their metabolites also influence stem cell biology, enhance neurogenesis to improve memory and augment autophagy to prolong life span. Thus, AA and other PUFAs and their anti-inflammatory metabolites inhibit inflammation, augment stem cell proliferation, restore to normal lipid-derived signaling molecules and NO and H<sub>2</sub>S production, enhance autophagy and prolong life span.
Hyperbranched polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents (2014)

A new macromolecular architecture comprising multiple linear-dendritic hybrid copolymer sub-units is presented – hyperbranched polydendrons. The materials are very high molecular weight and disperse but undergo extremely uniform self-assembly behaviour.
Multi-tap analog MIMO self-interference cancellation for full-duplex communications (2017)

Full-duplex (FD) multiple-input multiple-output (MIMO) systems can achieve simultaneous transmission and reception at the same frequency. In this paper, the FD MIMO system, where the multi-tap (MT) canceller is adopted to eliminate the self-interference (SI) with imperfect SI channel state information, is studied. Considering the dynamic range of the analog-to-digital converter and the linearity of the receiver chain, the achievable signal-to-interference-plus-noise ratio and the capacity of the FD MIMO system are both derived as a function of residual SI power after the MT cancellation. Simulation results show that the cancellation ability decreases as the tap delay alignment errors increase or the estimator signal-to-noise ratio reduces, which results in the loss of the signal-to-interference-plus-noise ratio of the intended terminal. As a result, considering the linearity of the receiver, we demonstrate that the capacity of FD transceivers with the high transmit power suffers from significant rate gain loss conditioned on 1% tap delay alignment errors.
Diversity and Habitat Preferences of Cultivated and Uncultivated Aerobic Methanotrophic Bacteria Evaluated Based on pmoA as Molecular Marker (2015)

Methane-oxidizing bacteria are characterized by their capability to grow on methane as sole source of carbon and energy. Cultivation-dependent and -independent methods have revealed that this functional guild of bacteria comprises a substantial diversity of organisms. In particular the use of cultivation-independent methods targeting a subunit of the particulate methane monooxygenase (pmoA) as functional marker for the detection of aerobic methanotrophs has resulted in thousands of sequences representing "unknown methanotrophic bacteria." This limits data interpretation due to restricted information about these uncultured methanotrophs. A few groups of uncultivated methanotrophs are assumed to play important roles in methane oxidation in specific habitats, while the biology behind other sequence clusters remains still largely unknown. The discovery of evolutionary related monooxygenases in non-methanotrophic bacteria and of pmoA paralogs in methanotrophs requires that sequence clusters of uncultivated organisms have to be interpreted with care. This review article describes the present diversity of cultivated and uncultivated aerobic methanotrophic bacteria based on pmoA gene sequence diversity. It summarizes current knowledge about cultivated and major clusters of uncultivated methanotrophic bacteria and evaluates habitat specificity of these bacteria at different levels of taxonomic resolution. Habitat specificity exists for diverse lineages and at different taxonomic levels. Methanotrophic genera such as Methylocystis and Methylocaldum are identified as generalists, but they harbor habitat specific methanotrophs at species level. This finding implies that future studies should consider these diverging preferences at different taxonomic levels when analyzing methanotrophic communities.
[Effect of transforming growth factor - beta1 on expression of CD69(+) and CD25(+) T cell induced by allo - corneal epithelial cells in vitro]. (2000)

TGF - beta(1) significantly inhibits the expression of CD(69)(+) and CD(25)(+) in peripheral T cells induced by allo-corneal epithelial cells in vitro.
A mathematical approach to cost minimization of satcom systems (2002)

A mathematical technique is described that formalizes the process of cost minimization in satcom systems by trading off interrelated parameters. It can be used as an aid to the traditional "spread-sheet" approach to indicate what modifications to parameters will lead to cost reduction, and if cost minimums exist. In the first step, the total life-cycle cost function is described as the sum of interrelated major terms. In turn, each of these consist of many terms. The second step is the determination of cost functions. Then, equations that tie certain of the component items together are determined. Finally, the cost is minimized by varying the component parameters to give the minimum total cost. Symbolic mathematical software is found to greatly ease this analysis. The approach is explained by means of three examples: (1) terminal power and antenna gain, and payload power and antenna gain are tied together with the link equations, (2) terminal reliability and maintainability are related by the availability relation, and (3) spacecraft sparing and reliability are balanced to achieve the specified constellation reliability. The examples show that cost minimums exist and can be determined with potential for considerable savings. The method is straightforward to extend to the entire life-cycle costing.
Localization of the Inhibitory Actions of Estrogen and Nicotine on Release of Luteinizing Hormone in Rats (1974)

Plasma LH was measured by radioimmunoassay inblood withdrawn through atrial cannulas at 10-min intervals in long-term ovariectomized (OVX) rats. A subcutaneous (s.c.) injection of estradiol benzoate or an intravenous (i.v.) injection of 17β-estradiol inhibited the pulsatile discharge of the hormone and depressed the plasma LH concentration. Neither progesterone nor small amounts of rat prolactin altered the pulsatile rhythm or lowered plasma LH levels. A s.c. injection of nicotine tartrate at a dosage which blocks the pro-estrous rise of LH caused a marked depression in plasma LH concentration. In rats which still exhibited pulsatile LH release after being subjected to partial or total deafferentation of the medial basal hypothalamus (MBH) 4–6 weeks prior to ovariectomy, injections of estradiol benzoate, 17β-estradiol and nicotine gave results similar to those seen in non-deafferented OVX animals. 17β-estradiol had a partial inhibitory effect on pituitary LH release in response to an injection of synthetic LHRH. The results suggest that the inhibitory effects of estrogen and nicotine on LH release are exerted via blockade of LHRH discharge from the MBH and that estrogen also inhibits LH release by an action on the adenohypophysis.
Salting-Out Effect of Ionic Liquids on Poly(propylene glycol) (PPG): Formation of PPG + Ionic Liquid Aqueous Two-Phase Systems (2010)

In the present work, aqueous poly(propylene glycol) (PPG) solution was separated into aqueous two-phase systems (ATPSs) in the presence of ionic liquid 1-allyl-3-methylimidazolium chloride ([Amim]Cl), 1-butyl-3-methylimidazolium acetate ([C4mim]Ac), or 1-butyl-3-methylimidazolium chloride ([C4mim]Cl). The top phase was PPG-rich, whereas the bottom phase was ionic liquid (IL)-rich. Liquid−liquid equilibrium data for the ATPSs and the salting-out coefficients of the ILs have been determined at 298.15 K and atmospheric pressure. It was shown that the binodal curves and the tie-lines could be described by a three-parameter equation and the Othmer−Tobias and Bancroft equations, respectively. The salting-out ability of the ILs on PPG was found to follow the order: [Amim]Cl > [C4mim]Ac > [C4mim]Cl > [C4mim][BF4]. Since PPG is a thermo-sensitive polymer and can be recovered simply by heating, these novel ATPSs are expected to have applications in the recycling and/or enrichment of hydrophilic ILs from aqueous solutions.
Purification of hemopoietic progenitor cells from human marrow using a fucose-binding lectin and cell sorting (1980)

Human peripheral blood granulocytes, but not lymphocytes, erythrocytes, or monocytes, bound the fucose-binding lectin from Lotus tetragonolobus (FBP), and this binding was competitively inhibited by the sugar alpha-L-fucose. The fluorescence-activated cell sorter was used to study the appearance of this receptor on human marrow cells during granulocyte differentiation and to prepare fractions enriched for granulocyte-macrophage progenitor cells (granulocyte-macrophage colony-forming cells--GM-CFC). Cell binding of fluoresceinated FBP increased for bone marrow cells in the sequence--lymphocytes, blast cells, promyelocytes and myelocytes, monocytes, and polymorphonuclear cells. Selection of cells with appropriate low-angle or high-angle light scatter characteristics achieved a 10-fold or 2-3-fold enrichment of progenitor cells, respectively. By selecting cells with intermediate fluorescence intensity, a further 2-3-fold enrichment for GM-CFC was obtained. Cell sorting using the optimal selection of these three parameters produced up to 36-fold enrichment of the progenitor cells from human bone marrow. The most enriched fraction was composed of 23% progenitor cells (colony- and cluster-forming cells) with a yield of 36%. In populations most highly enriched by GM-CFC, immature cells (blast cells, promyelocytes, and myelocytes) made up 95% of the cells present.
Sequence and secondary structure of 5.8S rRNA in the tick,<i>Ixodes scapularis</i> (1992)

Journal Article Sequence and secondary structure of 5.8S rRNA in the tick, Ixodes scapularis Get access Dawn M. Wesson, Dawn M. Wesson Malaria Branch, Mailstop F12, Centers for Disease ControlAtlanta, GA 30333, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank H. Collins Frank H. Collins Malaria Branch, Mailstop F12, Centers for Disease ControlAtlanta, GA 30333, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 20, Issue 5, 11 March 1992, Page 1139, https://doi.org/10.1093/nar/20.5.1139 Published: 11 March 1992 Article history Accepted: 27 January 1992 Published: 11 March 1992
Perspectives on Postharvest Biopesticides and Storage Technologies for Organic Produce (2006)

Fewer postharvest technologies are available for use on organic than conventional fruits and vegetables. Even though biopesticides are perceived as likely candidates for postharvest use on organic produce, only some biopesticides will be approved as organic compounds for various reasons. An example is the definition of a biopesticide used by regulatory agencies such as the EPA which includes compounds that will not be considered organically acceptable. Fortunately, there are other existing or new technologies that could be acceptable on organic fruits and vegetables. Some examples are hot water immersion treatment or a hot water rinsing and brushing, new innovative controlled atmosphere techniques, alternative sprout control agents, naturally occurring volatiles and biofumigants. More research is needed on each of these technologies, both singly and in combination with each other.
Predictive Models for the Breeder Genetic Algorithm I. Continuous Parameter Optimization (1993)

In this paper a new genetic algorithm called the Breeder Genetic Algorithm (BGA) is introduced. The BGA is based on artificial selection similar to that used by human breeders. A predictive model for the BGA is presented that is derived from quantitative genetics. The model is used to predict the behavior of the BGA for simple test functions. Different mutation schemes are compared by computing the expected progress to the solution. The numerical performance of the BGA is demonstrated on a test suite of multimodal functions. The number of function evaluations needed to locate the optimum scales only as n ln(n) where n is the number of parameters. Results up to n = 1000 are reported.
Toward the Nanoscopic “Electronic Nose”:  Hydrogen vs Carbon Monoxide Discrimination with an Array of Individual Metal Oxide Nano- and Mesowire Sensors (2006)

The array of chemiresistors made of individual pristine SnO2, surface doped (Ni)-SnO2 nanowires, and TiO2 and In2O3 mesoscopic whiskers was fabricated on a Si/SiO2 wafer. Their conductance was measured under pulses of H2 and CO reducing gases in oxygen as background gas. The nanostructures were shown to be n-type semiconductors possessing high sensitivity to the target gases. Following the "electronic nose" concept, correlation analysis of response of three-chemiresistor array is shown to be sufficient to discriminate between H2 and CO signals.
Damage-Resistant Composites Using Electrospun Nanofibers: A Multiscale Analysis of the Toughening Mechanisms (2016)

Today, fiber-reinforced polymer composites are a standard material in applications where a high stiffness and strength are required at minimal weight, such as aerospace structures, ultralight vehicles, or even flywheels for highly efficient power storage systems. Although fiber-reinforced polymer composites show many advantages compared to other materials, delamination between reinforcing plies remains a major problem limiting further breakthrough. Traditional solutions that have been proposed to toughen the interlaminar region between reinforcing plies have already reached their limit or have important disadvantages such as a high cost or the need for adapted production processes. Recently, electrospun nanofibers have been suggested as a more viable interlaminar toughening method. Although the expected benefits are numerous, the research on composite laminates enhanced with electrospun nanofibrous veils is still very limited. The work that has been done so far is almost exclusively focused on interlaminar fracture toughness tests with different kinds of nanofibers, where typically a trial and error approach has been used. A thorough understanding of the micromechanical fracture mechanisms and the parameters to obtain toughened composites has not been reported as of yet, but it is crucial to advance the research and design highly damage-resistant composites. This article provides such insight by analyzing the nanofiber toughening effect on three different levels for several nanofiber types. Only by combining the results from different levels, a thorough understanding can be obtained. These levels correspond to the hierarchical nature of a composite: the laminate, the interlaminar region, and the matrix resin. It is found that each level corresponds to certain mechanisms that result in a toughening effect. The bridging of microcracks by electrospun nanofibers is the main toughening mechanism resulting in damage resistance. Nevertheless, the way in which the nanofiber bridging mechanism expresses itself is different for each scale and dependent on parameters linked to a certain scale. The multiscale analysis of the toughening mechanisms reported in this paper is therefore crucial for understanding the behavior of nanofiber toughened composites, and as such allows for designing novel, damage-resistant, nanofiber-toughened materials.