gebhart/patrepeval huggingface dataset:
Environmental reliability and moisture barrier properties of silicon nitride and silicon oxide films using roll-to-roll plasma enhanced chemical vapor deposition (2021)

The moisture barrier properties and long-term reliability of flexible thin barrier films under harsh environmental conditions are crucial parameters to consider for the real-world applications of flexible electronics. In this study, we fabricated flexible barrier films of single-layer silicon nitride (SiNx) and silicon oxide (SiOx) on a polyethylene terephthalate substrate using plasma enhanced chemical vapor deposition. We investigated the stability and degradation mechanism of SiNx and SiOx barrier films at high temperature and under high humidity using water vapor transmission rate (WVTR) measurements and cyclic bending tests. The changes in chemical composition, film density, surface roughness, and WVTR were analyzed after environmental reliability tests. It was found that high temperature and high humidity induced oxidation of the SiNx and SiOx films, resulting in an increase in the surface roughness and decrease in the film density. The SiOx film was oxidized faster than the SiNx film and formed large hillocks on the surface. The WVTR values of both films increased as the reliability test time increased, especially under environmental conditions of 85 °C/85% relative humidity, with the barrier performance of the SiOx film degrading more than the SiNx film. The SiNx film displayed stable barrier performance during 10,000 cycles bending test at a fixed bending radius of 10 mm, even after harsh environmental reliability tests.
Inhibition of Serine Palmitoyl Transferase I Reduces Cardiac Ceramide Levels and Increases Glycolysis Rates following Diet-Induced Insulin Resistance (2012)

Our data reveal that although intra-myocardial ceramide does not accumulate following DIO, inhibition of de novo ceramide synthesis nonetheless reduces intra-myocardial ceramide levels and prevents the accumulation of intra-myocardial DAG. These effects improved the DIO-associated impairment of cardiac glycolysis rates, suggesting that SPT I inhibition increases cardiac glucose utilization.
Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells (2006)

Berberine, a naturally occurring isoquinoline alkaloid, has been shown to possess anti-inflammatory and antitumor properties in some in vitro systems. Here, we report that in vitro treatment of androgen-insensitive (DU145 and PC-3) and androgen-sensitive (LNCaP) prostate cancer cells with berberine inhibited cell proliferation and induced cell death in a dose-dependent (10-100 micromol/L) and time-dependent (24-72 hours) manner. Treatment of nonneoplastic human prostate epithelial cells (PWR-1E) with berberine under identical conditions did not significantly affect their viability. The berberine-induced inhibition of proliferation of DU145, PC-3, and LNCaP cells was associated with G1-phase arrest, which in DU145 cells was associated with inhibition of expression of cyclins D1, D2, and E and cyclin-dependent kinase (Cdk) 2, Cdk4, and Cdk6 proteins, increased expression of the Cdk inhibitory proteins (Cip1/p21 and Kip1/p27), and enhanced binding of Cdk inhibitors to Cdk. Berberine also significantly (P < 0.05-0.001) enhanced apoptosis of DU145 and LNCaP cells with induction of a higher ratio of Bax/Bcl-2 proteins, disruption of mitochondrial membrane potential, and activation of caspase-9, caspase-3, and poly(ADP-ribose) polymerase. Pretreatment with the pan-caspase inhibitor z-VAD-fmk partially, but significantly, blocked the berberine-induced apoptosis, as also confirmed by the comet assay analysis of DNA fragmentation, suggesting that berberine-induced apoptosis of human prostate cancer cells is mediated primarily through the caspase-dependent pathway. The effectiveness of berberine in checking the growth of androgen-insensitive, as well as androgen-sensitive, prostate cancer cells without affecting the growth of normal prostate epithelial cells indicates that it may be a promising candidate for prostate cancer therapy.
A review of beta antagonist treatment for infantile hemangioma. (2012)

Infantile hemangiomas are benign vascular neoplasms of childhood that often have implications on development, cosmesis, and comfort. Traditional therapy has involved either observation or corticosteroids, depending on location and size. Recent studies have reported the successful use of beta-adrenergic antagonists in treating infantile hemangiomas. This succinct review discusses the properties and current applications of beta-adrenergic antagonists as well as the established treatments for infantile hemangioma.
[Contribution to the mechanism of the "factor VIII bypassing activity" (FEIBA)-reaction]. (1990)

The principle of the FEIBactivity hadn't been defined in a sufficient manner up to now. Probably the factor VII or factor VIIa are playing a key role. According to own experiments the factor VII activity increases considerably in activated prothrombincomplex concentrates together with the quotient factor VIIa/VII. Factor VII should be administered in his activated form for bypassing. Fractions with limitation of the activation process to factor VII are of a low thrombogenicity. Among activated coagulation factors factor VIIa persists longest in the circulation and a bypass efficacy can be provoked only by this.
Redundant expression of canonical Wnt ligands in human breast cancer cell lines (2006)

Human breast cancer displays nuclear accumulation of beta-catenin and induction of cyclin D1 expression, which suggests that canonical Wnt/beta-catenin signaling is activated. In other cancers, the activation of canonical wnt/beta-catenin signaling is associated with APC, CTNNB1 or AXIN1 mutations. However, these mutations are rare or absent in breast cancer. In search of alternative mechanisms, we performed comprehensive expression analysis of Wnt signaling molecules, including 19 Wnt ligands, ten Frizzled receptors, two co-receptors and four Lef/TCF transcription factors in immortalized normal human mammary epithelial cells (HMEC) and six breast cancer cell lines. HMEC expressed all Frizzled receptors except FZD9 and FZD10. They also expressed LRP5 and LRP6 co-receptors, as well as four Lef/TCF transcription factors. HMEC cells also expressed many Wnt ligands, including WNT1, WNT2B, WNT3, WNT5A, WNT5B, WNT7B, WNT9A, WNT10B and WNT16. Redundant expression of Wnt ligands, Frizzled receptors, co-receptors and Lef/TCF transcription factors was maintained in breast cancer cell lines with some exceptions. The most important changes in cancer cell lines concerned Wnt ligand expression. We noticed that most breast cancer cell lines overexpressed WNT3A, WNT4, WNT6, WNT8B, WNT9A and WNT10B. In contrast, the expression of WNT5A, WNT5B and WNT16 was usually down-regulated. It is noteworthy that all six Wnt ligands that are overexpressed in malignant cell lines are known to signal through the canonical Wnt/beta-catenin signaling pathway, whereas down-regulated WNT5A and WNT5B ligands signal via the non-canonical pathway. The expression of both canonical Wnt ligands and most Frizzled receptors in breast cancer cell lines suggests that canonical Wnt/beta-catenin signaling is activated in these cell lines by an autocrine/paracrine mechanism. In support of this prediction, we observed nuclear beta-catenin accumulation and cyclin D1 induction in breast cancer cell lines, but not in HMEC. These results imply that ligand-dependent canonical Wnt/beta-catenin signaling is active in human breast cancer.
Energy-efficient signal processing in wearable embedded systems (2012)

Many wearable embedded systems benefit from classification algorithms where statistical features extracted from physiological signals are mapped onto different user's states such as health status of a patient or type of activity performed by a subject. Conventionally selected features lead to rapid battery depletion in these battery-operated systems, mainly due to the absence of computing complexity criterion while selecting prominent features. In this paper, we introduce the notion of power-aware feature selection, which minimizes energy consumption of the signal processing for classification applications. Our approach takes into consideration the energy cost of individual features that are calculated in real-time. The problem is formulated using integer programming and a greedy approximation is presented to select the features in a power-efficient manner. Experimental results on thirty channels of activity data demonstrate that our approach can significantly reduce energy consumption of the computing module resulting in more than 30$% energy savings while achieving 96.7% classification accuracy.
Vinculin in relation to stress fibers in spread platelets (1991)

To investigate the function of vinculin in blood platelets, we studied its localization in relation to other cytoskeletal proteins as well as its state of phosphorylation in platelets allowed to spread on fibrinogen-coated surfaces. By 5 minutes after loading the platelets onto the surfaces the 47 and 20 kDa polypeptides became phosphorylated, indicating activation. By 30 minutes, platelets formed small, typical bundles of fibers which stained brilliantly with rhodamine phalloidin. Myosin and tropomyosin, detected with specific antibodies, were localized in periodic arrays along these bundles. By indirect immunofluorescence, a discrete patch of vinculin was observed at each end of every actin-containing bundle. Vinculin phosphorylation was not detected in immunoprecipitates protected against phosphatases. Interference reflection images showed that regions of close binding to the substratum (adhesion plaques) closely matched the vinculin staining sites. Talin appeared diffusely localized. It could be shown to be present in the plaques when platelets were stabilized with ZnCl2 by the method of Geiger and then sonicated to remove some of the surface membrane. Localizations of vinculin and myosin were unaltered by this treatment. Talin phosphorylation or proteolysis could not account for vinculin translocation. We conclude that platelets, in response to an appropriate physiological surface, form typical actin bundles with vinculin at the termination of each bundle, in close relation to adhesion plaques. The signal for this translocation does not appear to depend on phosphorylation of vinculin or on phosphorylation or proteolysis of talin. Our findings support the conclusion that in platelets, as in nucleated cells, vinculin serves as at least part of the connection between bundled actin fibers and the extracellular matrix. Such a connection seems required for platelets' known ability to exert tension on surfaces.
Robust regression for data with multiple structures (2005)

In many vision problems (e.g., stereo, motion) multiple structures can occur in the data, in which case several instances of the same model need to be recovered from a single data set. However, once the measurement noise becomes significantly large relative to the separation between the structures, the robust statistical methods commonly used in the vision community tend to fail. In this paper, we show that all these techniques are special cases of the general class of M-estimators with auxiliary scale, and explain their failure in the presence of noisy multiple structures. To be able to cope with data containing multiple structures the techniques innate to vision (Hough and RANSAC) should be combined with the robust methods customary in statistics. The implications of our analysis are illustrated by introducing a simple procedure for 2D multistructured data problematic for all known current techniques.
Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury (2012)

Acute lung injury (ALI) is a syndrome marked by increased permeability across the pulmonary epithelium resulting in pulmonary edema. Recent evidence suggests that members of the human epidermal growth factor receptor (HER) family are activated in alveolar epithelial cells during ALI and regulate alveolar epithelial barrier function. These tyrosine kinase receptors, which also participate in the pathophysiology of pulmonary epithelial malignancies, regulate cell growth, differentiation, and migration as well as cell-cell adhesion, all processes that influence epithelial injury and repair. In this review we outline mechanisms of epithelial injury and repair in ALI, activation patterns of this receptor family in pulmonary epithelial cells as a consequence injury, how receptor activation alters alveolar permeability, and the possible intracellular signaling pathways involved. Finally, we propose a theoretical model for how HER-mediated modulation of alveolar permeability might affect lung injury and repair. Understanding how these receptors signal has direct therapeutic implications in lung injury and other diseases characterized by altered epithelial barrier function.
Grain growth of carbonates using ureolytic microbes (2011)

ウレアーゼ（尿素分解酵素）はある条件下で尿素を加水分解して炭酸イオンを生成する。その反応を利用して炭酸塩粒子を造ることができる。この尿素の加水分解はウレアーゼの触媒作用に依るので極めて速い。このようにして生成される炭酸塩は土粒子のバインダーとして，また固体表面の被覆や亀裂の充填などに適用可能である。そこで，本研究では工学的応用のために，わが国の土壌から単離した極めて有能なウレアーゼ産生微生物を使って，その炭酸塩生成のメカニズムを調べた。その結果，使用した培地，生成した炭酸塩の種類（使用金属イオン）と濃度，不純物などによって結晶や粒形のタイプと成長速度が変わることが分かった。また，MgとCaイオンを用いた場合には非晶の粒子が成長し，結晶より優れたバインダーとなる可能性が示された。
Systematic design of chemical oscillators. 39. Chemical oscillators in group VIA: the copper(II)-catalyzed reaction between hydrogen peroxide and thiosulfate ion (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSystematic design of chemical oscillators. 39. Chemical oscillators in group VIA: the copper(II)-catalyzed reaction between hydrogen peroxide and thiosulfate ionMiklos Orban and Irving R. EpsteinCite this: J. Am. Chem. Soc. 1987, 109, 1, 101–106Publication Date (Print):January 1, 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/ja00235a017https://doi.org/10.1021/ja00235a017research-articleACS PublicationsRequest reuse permissionsArticle Views320Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Rheology of Silica Dispersions in Organic Liquids:  New Evidence for Solvation Forces Dictated by Hydrogen Bonding (2000)

Dispersions of hydrophilic fumed silica are investigated in a range of polar organic media. The silica forms stable, low-viscosity sols exhibiting shear thickening behavior in a host of liquids, including ethylene glycol and its oligomers and short-chain alcohols, such as n-propanol. In contrast, the silica flocculates into colloidal gels in other liquids, such as glycols with methyl end-caps and longer-chain alcohols. We suggest that there is a causal relationship between the hydrogen-bonding ability of the liquid and the colloidal microstructure observed. In strongly hydrogen-bonding liquids, a solvation layer is envisioned to form on the silica surface through hydrogen bonding between liquid molecules and surface silanol groups (Si−OH). This gives rise to short-range, non-DLVO repulsions (“solvation forces”) which stabilize the silica particles. In contrast, in the case of liquids with limited hydrogen-bonding ability, silanols on adjacent silica particles are envisioned to interact directly by hydrogen bonding. This leads to particle flocculation and ultimately to gelation. Our study further fuels the debate regarding the existence of solvation forces in dispersions.
Multiple Octamer-Binding Proteins Are Targets for the Cell Cycle-Regulated Nuclear Inhibitor 1-92 (1995)

p92 is a novel sequence-specific octamer-binding factor interacting with the enhancer of human papillomavirus type 18. The nuclear inhibitor I-92 regulates the DNA binding activity of p92 during the cell cycle such that p92 DNA binding is restricted to S-phase. The sequence motif ++ 5'-AATTGCTTGCATAA, consisting of two partially overlapping octamer-related sequences, represents a recognition site for p92. It was the aim of this study to characterize the complexity of proteins interacting with the 5'-AATTGCTTGCATAA motif and to determine their regulation by I-92. UV cross-linking experiments showed that, besides p92, multiple novel proteins interact with the 5'-AATTGCTGCATAA motif. These novel proteins p84, p75, p73, p69, p61, p57, p49, and p46 specifically bind to this motif, although with different affinities. The inhibitor I-92 regulates, besides p92, the DNA-binding activities of p84, p75, p73, p69, and p57 but not of p61, p49, and p46. The association of I-92 with p92, p84, p75, p73, p69, and p57 was completely reversible after treatment with the detergent deoxycholate (DOC). Finally, we analyzed I-92 specificity and found that I-92 selectively inhibited DNA binding activities of partially purified octamer-binding proteins p84 and p92 whereas DNA binding of the POU factor Oct-1 was not regulated by I-92. Our results show that I-92 regulates multiple octamer-binding proteins and these findings provide an example how gene regulation could be linked to cell cycle regulation.
Radio frequency dc-dc power conversion (2006)

Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, February 2007.
Lost in virtual space: Studies in human and ideal spatial navigation. (2006)

The authors describe 3 human spatial navigation experiments that investigate how limitations of perception, memory, uncertainty, and decision strategy affect human spatial navigation performance. To better understand the effect of these variables on human navigation performance, the authors developed an ideal-navigator model for indoor navigation whose optimizing algorithm uses a partially observable Markov decision process. The model minimizes the number of actions (translations and rotations) required to move from an unknown starting state to a specific goal state in indoor environments that have perceptual ambiguity. The authors compared the model's performance with that of the human observer to measure human navigation efficiency. Experiment 1 investigated the effect of increasing the layout size on spatial way-finding efficiency and found that participants' efficiencies decreased as layout size increased. The authors investigated whether this reduction in navigation efficiency was due to visual perception (Experiment 2), memory, spatial updating strategy, or decision strategy (Experiment 3).
Novel silicon-on-insulator grating couplers based on CMOS poly-silicon gate layer (2011)

Grating couplers are widely investigated as a coupling interface between silicon-on-insulator waveguides and optical fibers. In this work, novel grating couplers based on strip poly-Si are proposed. This structure utilizes the poly-Si gate layer of the CMOS MOSFETs, and thus enables grating couplers integrated with CMOS circuits without adding any additional masks and process steps. Simulation results show that a coupling efficiency over 60% can be achieved between silicon-on-insulator waveguides and fibers.
5-Hydroxytryptamine – a local regulator of testicular blood flow and vasomotion in rats (1996)

The effects of 5-hydroxytryptamine (5-HT), 5-HT2 receptor antagonists (ritanserin and ketanserin), histamine and substance 48/80 on testicular blood flow and microcirculation were studied in adult rats. The substances were administered by topical application on the testicular surface and by intratesticular injections, and blood flow was measured by radioactive microspheres and with a laser Doppler flowmeter. Blood flow was decreased by 5-HT in a dose-dependent manner and vasomotion in the testis was inhibited, suggesting that it could be involved in the physiological regulation of the testicular vasculature. The 5-HT antagonists did not significantly influence flow or vasomotion in intact testes. Histamine did not cause any major effects on testicular blood flow. Substance 48/80 caused degranulation of testicular mast cells, and reduced testicular blood flow and vasomotion suggesting that testicular mast cells, possibly by releasing 5-HT, could be involved in the local control of the testicular vasculature.
Multi-agent event recognition (2002)

This paper presents a new approach to recognizing multiagent events observed by a static camera. To track objects robustly, knowledge about the ground plane and the events is used. An event is considered as composed of action threads, each thread being executed by a single actor. A single thread of action is recognized from the characteristics of the trajectory and moving blob of the actor using Bayesian methods. A multi-agent event is represented by a number of action threads related by temporal constraints. Multi-agent events are recognized by propagating the constraints and likelihoods of event threads in a temporal logic network.
Two- and Three-Dimensional Patterns of the Face (1999)

The human face is perhaps the most familiar and easily recognized object in the world, yet both its three-dimensional shape and its two-dimensional images are complex and hard to characterize. This book develops the vocabulary of ridges and parabolic curves, of illumination eigenfaces and elastic warpings for describing the perceptually salient fea
Shorter Notices (1992)

Shorter Notices Get access SARAH STREET SARAH STREET Bodleian LibraryOxford Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume CVII, Issue CCCCXXV, October 1992, Pages 1064-a–1064, https://doi.org/10.1093/ehr/CVII.CCCCXXV.1064-a Published: 01 October 1992
Remote limb ischemic post-conditioning attenuates ischemia-reperfusion injury in rat skin flapby limiting oxidative stress (2016)

Three cycles of 5-min Limb remote ischemic post-conditioning rather than a single cycle of 15-min limb RIPoC has protective effect on flaps against ischemia-reperfusion injury by attenuating oxidative stress.
Development of an acoustic method for the measurement of mixing and drying in a vibrated fluidized bed (2005)

A non-invasive acoustic method was developed to detect fluidization regimes, measure mixing and drying in a vibrated fluidized bed. The minimum fluidization and bubbling velocities can be determined from standard deviation of a microphone signal. The standard deviation of the acoustic emissions indicate the amplitude of the acoustic emissions. When the gas velocity is increased above the minimum fluidization velocity, the bed becomes fluidized. Increasing the gas velocity further, the bed becomes well mixed due to the action of the bubbles. The acoustic method can also detect moistures of a few tens of ppms.