gebhart/patrepeval huggingface dataset:
Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium (2008)

Rationale: After a myocardial infarction, necrosed cardiomyocytes are replaced by fibrotic tissue. Subsequent thinning and expansion of this non-elastic scar contributes to cardiac dilatation and congestive heart failure. We attempted to restore the elastic properties of the scar by implanting the infarct area with cells expressing elastin. Methods: Full-length elastin cDNA was generated by PCR using the human lung cDNA library, and then transfected (in adenoviral vector) into rat bone marrow stromal cells (BMSCs). Western blot and immuno-staining confirmed expression of elastin protein. Seven days after coronary artery ligation, BMSCs transfected with genes for either adeno-elastin (BMSC+Elastin) or adeno-green fluorescence protein (BMSC), or media (control group) were injected into the infarct area of adult rats (n=8/group). Results: Over 8 weeks following cell or media implantation, cardiac function (fractional shortening by echocardiography), ventricular volumes, and load independent indices of cardiac function (end systolic and diastolic volumes, preload recruitable stroke work and end systolic elastance by pressure-volume catheter), were all significantly better preserved in both BMSC groups (p<0.05 vs. media), with further improvements in the BMSC+Elastin group (p<0.05 vs. BMSC group). Biochemical analysis detected over-expression of recombinant elastin, and histological examination revealed that collagen fiber length and diameter were preserved in the scar tissue. Myocardial birefringence determined by polarized light (linear retardance of the tissue structure) was significantly highest in the infarct area of the BMSC+Elastin group (p<0.05 compared to BMSC and media groups). Elastin over-expression by cell-based gene therapy restored the elastic matrix structure in the scar tissue, stabilized the infarct and prevented ventricular dilatation, producing the smallest (p<0.05) scar size and surface area in the BMSC+Elastin group. Conclusions: Over-expression of elastin in transplanted BMSCs contributed to the alignment and organization of an elastic extracellular matrix structure, which prevented cardiac dilatation and dysfunction. Elastin plays a key role in the remodeling of the extracellular matrix.
Determination of optical properties of a two-layered epithelial model in UV-VIS (2005)

A combination of a variable -angle illumination and collection geometry and a Monte Carlo based light transport model was used to extract optical properties from a two-layered epithelial tissue model in the UV-Visible spectrum. This approach was validated using independent Monte Carlo simulations. The results indicated that the absorption coefficients were estimated with < 10% error and the scattering coefficients were estimated with < 15% error for both layers. The top layer thickness can be estimated with < 20% error for the thickness range from 200 µm to 500 µm.
Recovery of Greater Antigenic Reactivity in Conformationally Altered Albumin (1969)

Abstract Reduction of all 17 disulfide bonds of albumin followed by spontaneous reoxidation resulted in a 40 to 50% yield of a stable monomer (4 S) albumin which differed significantly in conformation from monomer (4 S) native albumin. This thermodynamically stable but conformationally altered reoxidized monomer albumin possessed greater antigenic reactivity than native monomer albumin. Other stable albumin moieties found upon reoxidation also differed significantly in conformation from native albumin but had varying degrees of antigenic loss.
UNIX for Dummies (1993)

The fun and friendly guide that takes the mystery out of UNIX. Covers all the UNIX essentials; from file and directory management to pipes, filters, security, passwords, and more. Includes a FREE Pull-Out UNIX Command Cheat Sheet of useful commands and tips.
Both cell proliferation and apoptosis increase with lesion grade in cervical neoplasia but do not correlate with human papillomavirus type. (1996)

Recent molecular studies suggest that the expression of high-risk but not low-risk human papillomavirus (HPV) oncoproteins E6 and E7 can significantly alter normal cell cycle regulation. The alterations in cell cycle regulation may be reflected by changes in the balance between cell growth and cell loss through apoptosis in cell populations expressing E6 and/or E7. We evaluated the kinetic indices of cell proliferation and apoptosis in a histopathological spectrum of cervical neoplasia and compared low-versus high-risk HPV-associated lesions. The cell proliferation index, as determined by detection of the nuclear antigen Ki67, increased with increasing lesion grade. Apoptotic cells were identified with terminal deoxynucleotidyl transferase-labeling of the 3'-hydroxyl ends of DNA nucleosomes. No apoptosis was observed in normal epithelium, and only occasional apoptotic cells were seen in low-grade lesions. However, there was a low but measurable apoptotic index in the higher grade lesions, which increased with lesion grade. There was no significant difference in the proliferative and apoptotic indices in similar grade lesions when stratified into low-versus high-risk HPV types. These findings suggest that apoptosis in HPV-infected lesions correlates with proliferative activity rather than HPV type.
Innovations in Locking Plate Technology (2004)

Plating techniques remain the mainstay for managing most periarticular and selected long bone fractures. However, movement toward more biologically appropriate plating techniques is occurring in an attempt to minimize soft-tissue stripping, decrease the need for bone grafting, and improve union rates. Internal fixation with locking plates creates a toggle-free, fixed-angle construct. Early data on the biomechanical and clinical performance of these implants are encouraging. Current indications for locked plating include periarticular fractures, typically those with metaphyseal comminution. Although impressive union rates have been reported, malunion remains a concern, especially when percutaneous techniques are used. Further clinical and biomechanical research on locking plate technology is needed to define its place fully alongside existing technology in orthopaedic trauma.
Swarm-determined electron attachment cross sections as a function of electron energy (1971)

An unfolding procedure is described whereby the known electron energy distribution function in the swarm F(( epsilon ), epsilon ) at each mean electron energy ( epsilon ) is used as the 'smearing out' function to unfold the monoenergetic attachment rate M( epsilon ) from the experimentally determined electron attachment rate functions Rexp(( epsilon )). From the monoenergetic attachment rate the absolute electron attachment cross section as a function of electron energy epsilon is calculated. The cross section functions determined from the unfolding of swarm data for a number of molecules compare well with those obtained using quasi-monoenergetic electron beams. This successful unfolding of swarm data enhances the potential of the electron swarm method in electron attachment studies.
Sphingobacterium multivorum septicemia: a case report. (1996)

A 47-year-old man presented with a history of fever, chills and weight loss for 3 months. He had been treated for diabetes mellitus during the past 3 years. He developed high fever with abnormal liver function tests. Both Widal and Weil-Felix reactions were negative with normal roentgenogram of the chest. His anti-HIV tests were positive. The cultures from the blood and sputum yielded pure Sphingobacterium multivorum sensitive to sulfamethoxazole-trimethoprim, chloramphenicol, tetracycline, cefotaxime, ceftazidine and ceftriaxone. On the next day, the patient developed signs and symptoms of meningitis with the CSF containing chronic and acute inflammatory cells but revealed no growth on culture. The patient was treated with a combination of ceftriazone and trimethoprim-sulfamethoxazole but he died on the 6th day after admission. This patient was the fifth reported case infected with S.multivorum. It illustrates that this potentially pathogenic organism can cause septicemia in an immunodeficient patient.
Polysialyltransferase-1 Autopolysialylation Is Not Requisite for Polysialylation of Neural Cell Adhesion Molecule (2000)

Polysialyltransferase-1 (PST; ST8Sia IV) is one of the alpha2, 8-polysialyltransferases responsible for the polysialylation of the neural cell adhesion molecule (NCAM). The presence of polysialic acid on NCAM has been shown to modulate cell-cell and cell-matrix interactions. We previously reported that the PST enzyme itself is modified by alpha2,8-linked polysialic acid chains in vivo. To understand the role of autopolysialylation in PST enzymatic activity, we employed a mutagenesis approach. We found that PST is modified by five Asn-linked oligosaccharides and that the vast majority of the polysialic acid is found on the oligosaccharide modifying Asn-74. In addition, the presence of the oligosaccharide on Asn-119 appeared to be required for folding of PST into an active enzyme. Co-expression of the PST Asn mutants with NCAM demonstrated that autopolysialylation is not required for PST polysialyltransferase activity. Notably, catalytically active, non-autopolysialylated PST does not polysialylate any endogenous COS-1 cell proteins, highlighting the protein specificity of polysialylation. Immunoblot analyses of NCAM polysialylation by polysialylated and non-autopolysialylated PST suggests that the NCAM is polysialylated to a higher degree by autopolysialylated PST. We conclude that autopolysialylation of PST is not required for, but does enhance, NCAM polysialylation.
Antiepileptic activity of preferential inhibitors of persistent sodium current (2014)

Our findings indicate that the selective persistent sodium current blocker GS967 has potent antiepileptic activity and that this compound could inform development of new agents.
A New Fuzzy Bandwidth Carrier Recovery System in GPS for Robust Phase Tracking (2004)

Fast carrier recovery loops are essential in high-dynamic global positioning system receivers. A new digital phase-locked loop (DPLL) system incorporating a fuzzy bandwidth controller (FBC) is presented in this letter. The FBC provides a time-varying bandwidth and adjusts the loop filter coefficients to improve DPLL tracking capability. When the phase error or phase difference error becomes large in the presence of significant accelerations, the loop bandwidth increases adaptively and performs rapid locking. Simulation results show that our receiver does achieve a superior performance over conventional tracking loops in terms of shorter settling time and wider frequency ramp range, while preventing the occurrence of cycle slipping.
Parallax polarizer barrier stereoscopic 3D display systems (2005)

A display system requiring no special glasses is useful for 3D images. The parallax barrier display system has superior characteristics, such as having a planar screen and a thin panel. However, a conventional parallax barrier display system has disadvantages such as having images with divided horizontal resolution. We describe a newly developed stereoscopic 3D display with a parallax polarizer barrier. The advantage of the parallax polarizer barrier is that the resolution of presented parallax images is much greater than that of a conventional display and see-through 3D images can be observed, because the 3D screen can multiplex projected images with horizontal and vertical polarization to display stereo views.
Fast Forward Selection to Speed Up Sparse Gaussian Process Regression (2003)

We present a method for the sparse greedy approximation of Bayesian Gaussian process regression, featuring a novel heuristic for very fast forward selection motivated by active learning. We show how a large number of hyperparameters can be adjusted automatically by maximizing the marginal likelihood of the training data. Our method is essentially as fast as an equivalent one which selects the &quot;support&quot; patterns at random, yet has the potential to outperform random selection on hard curve fitting tasks and at the very least leads to a more stable behaviour of first-level inference which makes the subsequent gradient-based optimization of hyperparameters much easier. In line with the development of our method, we present a simple view on sparse approximations for GP models and their underlying assumptions and show relations to other methods.
Summary of IEEE Standard 1459: Definitions for the Measurement of Electric Power Quantities Under Sinusoidal, Nonsinusoidal, Balanced, or Unbalanced Conditions (2004)

This paper describes the new IEEE Standard 1459, Definitions for the Measurement of Electric Power Quantities Under Sinusoidal, Nonsinusoidal, Balanced or Unbalanced Conditions. The information is presented in the context of historical events that explain the reasons for new definitions. The new definitions originate from S/sub e/, the effective apparent power definition attributed to F. Buchholz and W. Goodhue. The resolution of S/sub e/ extends from well-established concepts. The need for the separation of 60/50-Hz powers from the non-60/50 Hz-powers is emphasized. The standard serves users who want to evaluate the performance of modern equipment or to design and build the new generation of instrumentation.
Direct Synthesis of Allylic Thioethers Under Greener Conditions: A Solvent- and Catalyst-Free Approach (2014)

Abstract We present herein a new catalyst-free and solvent-free approach for the synthesis of allylic thioethers directly from allylic alcohols and thiols. The methodology allows the synthesis of different allylic thioethers in good to excellent yields under microwave irradiation. Theoretical calculations for the allylic carbocation helped to explain the regioselectivity observed when nonsymmetric substrates are used in the reaction.
Optical Properties of Colloid Liquid Crystal Composites (2001)

Abstract Colloid-liquid crystal composites are a recently discovered class of soft solid comprising a dense dispersion of spherical colloidal particles in a liquid crystalline host with unusual mechanical properties. We applied this class of system to a variety of liquid crystal device modes such as twist nematic, homogenous aligned, White-Taylor GH and reflective cholesteric devices. The observed electro-optical response suggests that the local viscosity (controlling molecular reorientation) is decoupled from the (much higher) bulk viscosity. Over a wide range of particle concentrations across the full temperature range of the nematic phase, strong electro-optical switching is observed for 5CB and several of the commercially available liquid crystal mixtures. Contrast ratio, viewing angle characteristics, switching time and optical hysteresis exhibit a significant dependencies on particle density. We also demonstrate that how morphologies of the liquid crystal confined between the substrates affect the optical properties.
Perinatal Ischemic Stroke (2007)

Perinatal ischemic stroke is not rare in term and near-term infants and is an important antecedent of long-term neurological disability, including congenital hemiplegia (hemiplegic cerebral palsy) and seizure and cognitive disorders. Changes in maternal hemostasis occur in pregnancy and are amplified in the period immediately surrounding birth; stroke and other thromboembolic events are more frequent in both mother and infant in this period. The vasculature and hemostatic mechanisms of placenta as well as brain are likely to be important in the pathobiology of perinatal stroke. Maternal and infant thrombophilias, genetic and acquired, play a role. Rarely is >1 child in a sibship affected, and environmental factors-substantially less studied, to date--are likely to be key determinants of risk.
Neither Here nor There (2015)

Abstract This chapter examines the themes of grief and absence in Emerson's well-known essay "Experience." The essay is interpreted not as "representing grief" (as in Sharon Cameron's famous reading) but instead as concerned with the very impossibility of representation. Much as in the self-referential approach applied by Edwards to ethics and Peirce to reality, Emerson finds that the memory of his lost child, and with this the child himself, is approachable only as unapproachable.
Excel 2003 Just the Steps For Dummies (2006)

Pick your Excel task, find it fast, and get it done with Just the Steps! If you want to see how to do a particular Excel task, this is the perfect book. Each page includes step-by-step instruction in one column and illustrations and screenshots in the other column, so you have all the information you need in one placeno flipping pages! Improve your Excel skills with just the steps for entering spreadsheet data, building formulas, protecting excel data, formatting cells, designing spreadsheets with graphics, managing workbooks, changing worksheet values, sorting and filtering data, creating charts, creating PivotTables, building macros, integrating Excel into other Office programs, andwhew!still more. Explains essentials tasks for Excel 2010, the spreadsheet application that is part of the Microsoft Office 2010 suite Shows you just the steps for numerous Excel tasks using an easy-to-follow, two-column page layout, with step-by-step instruction on one side and illustrations and screenshots on the other Covers entering spreadsheet data, building formulas, protecting excel data, formatting cells, designing spreadsheets with graphics, managing workbooks, changing worksheet values, sorting and filtering data, creating charts, creating PivotTables, and building macros Walks you step by step through collaborating in Excel and integrating or using Excel with Word, PowerPoint, and Access Make your tasks easier, improve your Excel skills, and get better results with this step-by-step guide.
Process compatible polysilicon-based electrical through-wafer interconnects in silicon substrates (2002)

Electrical through-wafer interconnects (ETWI) which connect devices between both sides of a substrate are critical components for microelectromechanical systems (MEMS) and integrated circuits (IC), as they enable three-dimensional (3-D) structures and permit new packaging and integration geometries. Previously demonstrated ETWI are very difficult to integrate with standard semiconductor fabrication processes, not compatible with released sensors, do not permit extensive processing on both sides of the wafer, and are in general very application specific. This work describes the design, fabrication, and characterization of an ETWI technology for silicon substrates that can be broadly integrated with MEMS and IC processes. This interconnect is a passively isolated electrical through-wafer polysilicon plug, with a 20 /spl mu/m diameter, 10-14 /spl Omega/ resistance, and less than 1 pF capacitance. Plasma etching from both sides of the wafer is used to achieve a high-aspect ratio via (20:1 through 400 /spl mu/m). The process is compatible with standard lithography, standard wafer handling, subsequent high-temperature processing, and released sensors integration. N-type and p-type versions are demonstrated, and isolated ground planes are added to provide shielding against substrate noise. Electrical properties of these ETWI are measured and analytically modeled. These ETWI are appropriate for integration with devices with impedances much greater than the ETWI, such as piezoresistive and capacitive sensor arrays.
Compromised LCAT Function Is Associated With Increased Atherosclerosis (2005)

The data show that heterozygosity for LCAT gene defects is associated with low HDL-C levels and elevated concentration of triglycerides and CRP in plasma. This phenotype underlies increased IMT in carriers versus controls, which suggests that LCAT protects against atherosclerosis. This in turn indicates that targeting LCAT to raise HDL-C may reduce CVD risk.
Current Concepts of Follicle-Stimulating Hormone Receptor Gene Regulation1 (2010)

Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and granulosa cells of the ovary. Thus, both the magnitude and the target of hormone response are controlled by mechanisms that determine FSHR levels and cell-specific expression, which are supported by transcription of its gene. The present review examines the status of FSHR/Fshr gene regulation, emphasizing the importance of distal sequences in FSHR/Fshr transcription, new insights gained from the influx of genomics data and bioinformatics, and emerging trends that offer direction in deciphering the FSHR/Fshr regulatory landscape.
[Composition and property characterization of Rhizoma Dioscoreae polysaccharide-Fe (III) complex]. (2008)

This is the first report of RDPC which was stable under physiological pH conditions and could be a new candidate for iron-supplementary.
CDNA SEQUENCE AND EXPRESSION OF THE MOUSE ALPHA 1(V) COLLAGEN GENE (COL5A1) (1998)

Several overlapping cDNA clones corresponding to the entire coding sequence of the mouse a 1 V collagen gene . . Col5a1 were isolated. The conceptual amino acid translation indicated a high degree of sequence identity 94% with the . . human a 1 V chain. All of the important structures previously noted in the human a 1 V chain were also conserved in the . . mouse chain. The a 1 V transcripts were easily detected in mouse embryos as early as 11 days post coitum d.p.c. . The transcripts were widely distributed in non-cartilaginous and cartilaginous tissues. Finally, we calculated the ratio of . . . transcripts of a 1V: a 2V: a 1 XI in the calvaria and tongue of 18 d.p.c. embryos using the competitive reverse . transcription-polymerase chain reaction RT-PCR technique. The results raised the possibility that there are at least two different kind of types VrXI collagen heterotrimers in mouse embryonic tissues. q 1998 Elsevier Science B.V. .
The Polymerization of l-Propylene Oxide<sup>1</sup> (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Polymerization of l-Propylene Oxide1Charles C. Price and Maseh OsganCite this: J. Am. Chem. Soc. 1956, 78, 18, 4787–4792Publication Date (Print):September 1, 1956Publication History Published online1 May 2002Published inissue 1 September 1956https://pubs.acs.org/doi/10.1021/ja01599a066https://doi.org/10.1021/ja01599a066research-articleACS PublicationsRequest reuse permissionsArticle Views637Altmetric-Citations201LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hydrothermal Corrosion of Pure, Hot Isostatically Pressed Silicon Nitride (1993)

The aqueous corrosion behavior of hot isostatically pressed Si 3 N 4 (HIPed‐Si 3 N 4 ) without additives was studied under hydrothermal conditions at 300°C and 8.6 MPa (86 atm). The accelerated weight loss in the HIPed‐Si 3 N 4 was attributed to uniform thinning of the specimen accompanied by dislodgement of Si 3 N 4 grains from the substrate due to preferential attack at grain boundaries. Enhanced attack at grain boundaries was due to the presence of amorphous SiO 2 from impurities in the starting powder.