gebhart/patrepeval huggingface dataset:
Gate sizing using incremental parameterized statistical timing analysis (2005)

As technology scales into the sub-90 nm domain, manufacturing variations become an increasingly significant portion of circuit delay. As a result, delays must be modeled as statistical distributions during both analysis and optimization. This paper uses incremental, parametric statistical static timing analysis (SSTA) to perform gate sizing with a required yield target. Both correlated and uncorrelated process parameters are considered by using a first-order linear delay model with fitted process sensitivities. The fitted sensitivities are verified to be accurate with circuit simulations. Statistical information in the form of criticality probabilities are used to actively guide the optimization process which reduces run-time and improves area and performance. The gate sizing results show a significant improvement in worst slack at 99.86% yield over deterministic optimization.
Cloning and Characterization of the Gene for β-Tubulin from a Benomyl-Resistant Mutant of <i>Neurospora crassa</i> and Its Use as a Dominant Selectable Marker (1986)

We cloned the beta-tubulin gene of Neurospora crassa from a benomyl-resistant strain and determined its nucleotide sequence. The gene encodes a 447-residue protein which shows strong homology to other beta-tubulins. The coding region is interrupted by six introns, five of which are within the region coding for the first 54 amino acids of the protein. Intron position comparisons between the N. crassa gene and other fungal beta-tubulin genes reveal considerable positional conservation. The mutation responsible for benomyl resistance was determined; it caused a phenylalanine-to-tyrosine change at position 167. Codon usage in the beta-tubulin gene is biased, as has been observed for other abundantly expressed N. crassa genes such as am and the H3 and H4 histone genes. This bias results in pyrimidines in the third positions of 96% of the codons in codon families in which there is a choice between purines and pyrimidines in this position. Bias is also evident by the absence of 19 of the 61 sense codons. We demonstrated that benomyl resistance is due to the cloned beta-tubulin gene of strain Bml511(r)a and that this gene can be used as a dominant selectable marker in N. crassa transformation.
Perils and pitfalls of practical cybercommerce (1996)

article Free AccessPerils and pitfalls of practical cybercommerce Author: Nathaniel S. Borenstein First Virtual Holdings, Ann Arbor, MI First Virtual Holdings, Ann Arbor, MIView Profile Authors Info & Claims Communications of the ACMVolume 39Issue 601 June 1996pp 36–44https://doi.org/10.1145/228503.228510Published:01 June 1996Publication History 33citation702DownloadsMetricsTotal Citations33Total Downloads702Last 12 Months21Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Multicriteria optimization for managing tradeoffs in radiation therapy treatment planning (2013)

Treatment planning for radiation therapy inherently involves tradeoffs, such as between tumor control and normal tissue sparing, between time-efficiency and dose quality, and between nominal plan quality and robustness. The purpose of this thesis is to develop methods that can facilitate decision making related to such tradeoffs. The main focus of the thesis is on multicriteria optimization methods where a representative set of treatment plans are first calculated and the most appropriate plan contained in this representation then selected by the treatment planner through continuous interpolation between the precalculated alternatives. These alternatives constitute a subset of the set of Pareto optimal plans, meaning plans such that no criterion can be improved without a sacrifice in another. Approximation of Pareto optimal sets is first studied with respect to fluence map optimization for intensity-modulated radiation therapy. The approximation error of a discrete representation is minimized by calculation of points one at the time at the location where the distance between an inner and outer approximation of the Pareto set currently attains its maximum. A technique for calculating this distance that is orders of magnitude more efficient than the best previous method is presented. A generalization to distributed computational environments is also proposed. Approximation of Pareto optimal sets is also considered with respect to direct machine parameter optimization. Optimization of this form is used to calculate representations where any interpolated treatment plan is directly deliverable. The fact that finite representations of Pareto optimal sets have approximation errors with respect to Pareto optimality is addressed by a technique that removes these errors by a projection onto the exact Pareto set. Projections are also studied subject to constraints that prevent the dose-volume histogram from deteriorating. Multicriteria optimization is extended to treatment planning for volumetric-modulated arc therapy and intensity-modulated proton therapy. Proton therapy plans that are robust against geometric errors are calculated by optimization of the worst case outcome. The theory for multicriteria optimization is extended to accommodate this formulation. Worst case optimization is shown to be preferable to a previous more conservative method that also protects against uncertainties which cannot be realized in practice.
Properties and performance of extended target motion analysis (1996)

The problem of target motion analysis (TMA) has been the subject of an important literature. However, present methods use data estimated by a short time analysis (azimuths, Dopplers, etc.). For far sources, the nonstationarities of the array processing outputs, induced by the sources motion, may be simply modeled. This model leads one to consider directly a spatio-temporal TMA. Then new (spatio-temporal) data can be estimated. These estimates correspond to a long time analysis. Further, note that they are estimated independently of the (classical) bearings. In this general framework, the concept of source trajectory replaces the classical instantaneous bearings. Corresponding TMA algorithms are then studied. Then the study of statistical performance is carefully studied.
<i>In vivo</i> release of vancomycin from biodegradable beads (2002)

The current delivery system of antibiotics for the treatment of osteomyelitis uses polymethylmethacrylate (PMMA) beads as a local drug-release agent. The nonbiodegradable nature of the PMMA, however, necessitates a second operation to remove the beads. This article explores the alternative of using biodegradable polymers as antibiotic beads for a long-term drug release in vivo. To manufacture an antibiotic bead, lactide-glycolide copolymers were mixed with vancomycin. The mixture was compressed and sintered at 55 degrees C to form beads 8 mm in diameter. An in vivo animal model was proposed to characterize the elution rate of antibiotic over a 55-day period. Biodegradable beads released high concentrations of antibiotic (well above the breakpoint sensitivity concentration) in vivo for the period of time needed to treat bone infection; that is, 4-6 weeks. A bacterial inhibition test was also carried out to determine the relative activity of the released antibiotics. The diameter of the sample inhibition zone ranged from 8 to 18 mm, which is equivalent to 9.1 to 100% of relative activity. In addition, the antibiotic concentration of systemic blood was found to be very low. Antibiotic-impregnated biodegradable beads may have a potential role in the prevention and management of surgical infections.
Germanium nanowire field-effect transistors with SiO2 and high-κ HfO2 gate dielectrics (2003)

Single-crystal Ge nanowires are synthesized by a low-temperature (275 °C) chemical vapor deposition (CVD) method. Boron doped p-type GeNW field-effect transistors (FETs) with back-gates and thin SiO2 (10 nm) gate insulators are constructed. Hole mobility higher than 600 cm2/V s is observed in these devices, suggesting high quality and excellent electrical properties of as-grown Ge wires. In addition, integration of high-κ HfO2 (12 nm) gate dielectric into nanowire FETs with top-gates is accomplished with promising device characteristics obtained. The nanowire synthesis and device fabrication steps are all performed below 400 °C, opening a possibility of building three-dimensional electronics with CVD-derived Ge nanowires.
Methods and algorithms for Fourier-transform nuclear magnetic resonance tomography (1987)

In nuclear magnetic resonance (NMR) imaging there are two main image formation approaches, the direct Fourier imaging method proposed by Kumar et al. [J. Mag. Res. 88, 69 (1975)] and the projection reconstruction technique commonly used in conventional computed tomography. In this paper these two approaches are reviewed with particular reference to Fourier-transform NMR imaging or tomography. Although Fourier imaging is the most conventional imaging method, useful applications for projection reconstruction techniques have often been found in NMR imaging. Therefore, in this paper, the emphasis is placed more on the projection reconstruction techniques that may not be readily available in NMR imaging.
Adsorption of Water on Reconstructed Rutile TiO<sub>2</sub>(011)-(2×1):  TiO Double Bonds and Surface Reactivity (2005)

Recent combined experimental and theoretical studies (Beck et al., Phys. Rev. Lett. 2004, 93, 036104) have provided evidence for Ti=O double-bonded titanyl groups on the reconstructed rutile TiO(2)(011)-(2 x 1) surface. The adsorption of water on the same surface is now investigated to further probe the properties of these groups, as well as to confirm their existence. Ultraviolet photoemission experiments show that water is adsorbed in molecular form at a sample temperature of 110 K. At the same time, the presence of a 3sigma state in the photoemission spectra and work function measurements indicate a significant amount of hydroxyls within the first monolayer of water. At room temperature, scanning tunneling microscopy (STM) suggests that dissociated water is present, and about 30% of the surface active sites are hydroxylated. These findings are well explained by total energy density functional theory calculations and Car-Parrinello molecular dynamics simulations for water adsorption on the titanyl model of TiO(2)(011)-(2 x 1). The theoretical results show that a mixed molecular/dissociative layer is the most stable configuration in the monolayer regime at low temperatures, while complete dissociation takes place at 250 K. The arrangement of the protonated mono-coordinated oxygens in the mixed molecular/dissociated layer is consistent with the observed short-range order of the hydroxyls in the STM images.
Computational Complexity and Fundamental Limitations to Fermionic Quantum Monte Carlo Simulations (2005)

Quantum Monte Carlo simulations, while being efficient for bosons, suffer from the "negative sign problem" when applied to fermions--causing an exponential increase of the computing time with the number of particles. A polynomial time solution to the sign problem is highly desired since it would provide an unbiased and numerically exact method to simulate correlated quantum systems. Here we show that such a solution is almost certainly unattainable by proving that the sign problem is nondeterministic polynomial (NP) hard, implying that a generic solution of the sign problem would also solve all problems in the complexity class NP in polynomial time.
New High-Pressure Structural Transition of Oxygen at 96 GPa Associated with Metallization in a Molecular Solid (1995)

By using a high-energy and high-brilliance synchrotron radiation source in the European Synchrotron Radiation Facility and the Photon Factory, an angle-dispersive powder x-ray diffraction study of solid oxygen has been carried out up to 116 GPa at room temperature. A new high-pressure structural transition was observed at 96 GPa and explained as an isostructural transition with a discontinuous change in lattice constants in a monoclinic cell. Metallization of oxygen reported by Desgreniers, Vohra, and Ruoff [J. Phys. Chem. 94, 1117 (1990)] is ascribed to the transition.
ELEGANT: Exchanging Latent Encodings with GAN for Transferring Multiple Face Attributes (2018)

Recent studies on face attribute transfer have achieved great success. A lot of models are able to transfer face attributes with an input image. However, they suffer from three limitations: (1) incapability of generating image by exemplars; (2) being unable to transfer multiple face attributes simultaneously; (3) low quality of generated images, such as low-resolution or artifacts. To address these limitations, we propose a novel model which receives two images of opposite attributes as inputs. Our model can transfer exactly the same type of attributes from one image to another by exchanging certain part of their encodings. All the attributes are encoded in a disentangled manner in the latent space, which enables us to manipulate several attributes simultaneously. Besides, our model learns the residual images so as to facilitate training on higher resolution images. With the help of multi-scale discriminators for adversarial training, it can even generate high-quality images with finer details and less artifacts. We demonstrate the effectiveness of our model on overcoming the above three limitations by comparing with other methods on the CelebA face database. A pytorch implementation is available at https://github.com/Prinsphield/ELEGANT.
Microcirculation and hemorheology in cerebrovascular accidents and hypertension: an application of laser Doppler flowmetry (2002)

The aim of this study was to analyze the peripheral microvasculature status noninvasively in high risk i.e. hypertensive controls, normal controls and recent stroke cases having a history of hypertension, using a combination of laser Doppler flowmetry and reactive hyperemia (RH). A second aim was to evaluate significant blood viscosity factors which may be involved in altered microcirculation in high risk and recent stroke cases not more than 24 hours old. Blood viscosity factors were routinely evaluated in the authors' laboratory. RH was induced by arterial occlusion of 3.5 min. duration in the forearm of all the 3 groups. Microcirculatory parameters observed from the RH test are presented and discussed in the light of the hemorheological parameters obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel Nanoparticle‐Reinforced Metal Matrix Composites with Enhanced Mechanical Properties (2007)

Abstract This paper summarizes and reviews the state‐of‐the‐art processing methods, structures and mechanical properties of the metal matrix composites reinforced with ceramic nanoparticles. The metal matrices of nanocomposites involved include aluminum and magnesium. The processing approaches for nanocomposites can be classified into ex‐situ and in‐situ synthesis routes. The ex‐situ ceramic nanoparticles are prone to cluster during composite processing and the properties of materials are lower than the theoretical values. Despite the fact of clustering, ex‐situ nanocomposites reinforced with very low loading levels of nanoparticles exhibit higher yield strength and creep resistance than their microcomposite counterparts filled with much higher particulate content. Better dispersion of ceramic nanoparticles in metal matrix can be achieved by using appropriate processing techniques. Consequently, improvements in both the mechanical strength and ductility can be obtained readily in aluminum or magnesium by adding ceramic nanoparticles. Similar beneficial enhancements in mechanical properties are observed for the nanocomposites reinforced with in‐situ nanoparticles.
Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumatic Brain Injuries (2017)

There is a subset of patients with mild traumatic brain injury (mTBI) who report persistent symptoms that impair their functioning and quality of life. Being able to predict which patients will experience prolonged symptom recovery would help clinicians target resources for clinical follow-up to those most in need, and would facilitate research to develop precision medicine treatments for mTBI. The purpose of this study was to investigate the predictors of symptom recovery in a prospective sample of emergency department trauma patients with either mTBI or non-mTBI injuries. Subjects were examined at several time points from within 72 h to 45 days post-injury. We quantified and compared the value of a variety of demographic, injury, and clinical assessment (symptom, neurocognitive) variables for predicting self-reported symptom duration in both mTBI (n = 89) and trauma control (n = 73) patients. Several injury-related and neuropsychological variables assessed acutely (< 72 h) post-injury predicted symptom duration, particularly loss of consciousness (mTBI group), acute somatic symptom burden (both groups), and acute reaction time (both groups), with reasonably good model fit when including all of these variables (area under the receiver operating characteristic curve [AUC] = 0.76). Incorporating self-reported litigation involvement modestly increased prediction further (AUC = 0.80). The results highlight the multifactorial nature of mTBI recovery, and injury recovery more generally, and the need to incorporate a variety of variables to achieve adequate prediction. Further research to improve this model and validate it in new and more diverse trauma samples will be useful to build a neurobiopsychosocial model of recovery that informs treatment development.
Biotechnological Applications of Acetic Acid Bacteria (2008)

The acetic acid bacteria (AAB) have important roles in food and beverage production, as well as in the bioproduction of industrial chemicals. In recent years, there have been major advances in understanding their taxonomy, molecular biology, and physiology, and in methods for their isolation and identification. AAB are obligate aerobes that oxidize sugars, sugar alcohols, and ethanol with the production of acetic acid as the major end product. This special type of metabolism differentiates them from all other bacteria. Recently, the AAB taxonomy has been strongly rearranged as new techniques using 16S rRNA sequence analysis have been introduced. Currently, the AAB are classified in ten genera in the family Acetobacteriaceae. AAB can not only play a positive role in the production of selected foods and beverages, but they can also spoil other foods and beverages. AAB occur in sugar- and alcohol-enriched environments. The difficulty of cultivation of AAB on semisolid media in the past resulted in poor knowledge of the species present in industrial processes. The first step of acetic acid production is the conversion of ethanol from a carbohydrate carried out by yeasts, and the second step is the oxidation of ethanol to acetic acid carried out by AAB. Vinegar is traditionally the product of acetous fermentation of natural alcoholic substrates. Depending on the substrate, vinegars can be classified as fruit, starch, or spirit substrate vinegars. Although a variety of bacteria can produce acetic acid, mostly members of Acetobacter, Gluconacetobacter, and Gluconobacter are used commercially. Industrial vinegar manufacturing processes fall into three main categories: slow processes, quick processes, and submerged processes. AAB also play an important role in cocoa production, which represents a significant means of income for some countries. Microbial cellulose, produced by AAB, possesses some excellent physical properties and has potential for many applications. Other products of biotransformations by AAB or their enzymes include 2-keto-L-gulonic acid, which is used for the production of vitamin C; D-tagatose, which is used as a bulking agent in food and a noncalorific sweetener; and shikimate, which is a key intermediate for a large number of antibiotics. Recently, for the first time, a pathogenic acetic acid bacterium was described, representing the newest and tenth genus of AAB.
Phospholipids that Contain Polyunsaturated Fatty Acids Enhance Neuronal Cell Mechanics and Touch Sensation (2014)

Mechanoelectrical transduction (MeT) channels embedded in neuronal cell membranes are essential for touch and proprioception. Little is understood about the interplay between native MeT channels and membrane phospholipids, in part because few techniques are available for altering plasma membrane composition in vivo. Here, we leverage genetic dissection, chemical complementation, and optogenetics to establish that arachidonic acid (AA), an omega-6 polyunsaturated fatty acid, enhances touch sensation and mechanoelectrical transduction activity while incorporated into membrane phospholipids in C. elegans touch receptor neurons (TRNs). Because dynamic force spectroscopy reveals that AA modulates the mechanical properties of TRN plasma membranes, we propose that this polyunsaturated fatty acid (PUFA) is needed for MeT channel activity. These findings establish that polyunsaturated phospholipids are crucial determinants of both the biochemistry and mechanics of mechanoreceptor neurons and reinforce the idea that sensory mechanotransduction in animals relies on a cellular machine composed of both proteins and membrane lipids.
Computer manikin family usage for human accomodation (2003)

Commonly percentiles are used to define users’ bodily dimensions. The percentile approach is however not suitable for multivariate problems such as the design of car cockpits, i.e. where a range of body segment dimensions affects the design. An alternative way is to use a set, a family, of manikins for evaluation that better represents human variety. The aim of this study was to compare seat and steering wheel adjustment ranges obtained when using manikin families or a percentile approach as the user representation in human simulation software. Results obtained indicate that a more elaborate and careful consideration of users can be achieved when using a manikin family approach for human accommodation compared to a percentile approach.
The Virtual Business Services Fabric: An Integrated Abstraction of Services and Computing Infrastructure (2009)

This paper introduces (i) the concept of business services as a fabric that is a network of networks consisting of service components; (ii) proposes partitioning and composition schemes for creating a virtualized services fabric; and (iii) an agent based infrastructure services fabric to implement knowledge based policies and business workflows. The proposed VBSF - a model for heterogeneous virtualization and abstraction of services, applications, policies, capabilities, resources, infrastructure and, even, people - allows dynamic allocation of resources and dynamic assembly (composition) of business workflows. This model is applicable to services and infrastructural environments that transcend public and private clouds, services, applications and infrastructures.