gebhart/patrepeval huggingface dataset:
Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? (2021)

The COVID-19 pandemic, caused by the rapid global spread of the novel coronavirus (SARS-CoV-2), has caused healthcare systems to collapse and led to hundreds of thousands of deaths. The clinical spectrum of COVID-19 is not only limited to local pneumonia but also represents multiple organ involvement, with potential for systemic complications. One year after the pandemic, pathophysiological knowledge has evolved, and many therapeutic advances have occurred, but mortality rates are still elevated in severe/critical COVID-19 cases. Mesenchymal stromal cells (MSCs) can exert immunomodulatory, antiviral, and pro-regenerative paracrine/endocrine actions and are therefore promising candidates for MSC-based therapies. In this review, we discuss the rationale for MSC-based therapies based on currently available preclinical and clinical evidence of safety, potential efficacy, and mechanisms of action. Finally, we present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic's unmet medical needs.
Development of a Chromosomally Integrated Metabolite-Inducible Leu3p-α-IPM “Off-On” Gene Switch (2010)

Our results demonstrate that the 'Leu3p-alpha-IotaRhoMu' constitutes a simpler and safer system for inducible gene expression in biomedical applications.
Syntheses and Reactions of 3-Amino-4 (3H)-pyrimidones (1971)

The reaction of β-keto esters with aminoguanidine afforded 2, 3-diamino-4 (3H)-pyrimidones (IV), which were employed for the cyclization to 5, 8-dihydro-s-triazolo [1, 5-a] pyrimidin-5-ones (V) and 1, 2-dihydro-3-methyl-6H-pyrimido [1, 2-b] as-triazine-2, 6-diones (VIII). Further treatment of β-keto esters with thiosemicarbazide gave 3-amino-4 (3H)=oxo-2 (1H)-pyrimidinethiones (XII). 7-Methyl-5H-1, 3, 4-thiadiazolo [3, 2-a] pyrimidin-5-one (XIV) was derived from the 6-methyl derivative of XII.
NMR study of the galactomannans of <i>Trichophyton mentagrophytes</i> and <i>Trichophyton rubrum</i> (1997)

Around 90% of chronic dermatophyte infections are caused by the fungi Trichophyton mentagrophytes and Trichophyton rubrum. One of the causes of the chronic infection resides in the immunosuppressive effects of the cell-wall components of these organisms. Therefore we have attempted to identify the chemical structure of galactomannan, one of the major cell-wall components. The cell-wall polysaccharides secreted by T. mentagrophytes and T. rubrum were isolated from the culture medium and fractionated into three subfractions by DEAE-Sephadex chromatography. Analysis of each subfraction by NMR indicated that there are two kinds of polysaccharides present, i.e. mannan and galactomannan. The mannan has a linear backbone consisting of alpha1,6-linked mannose units, with alpha1,2-linked mannose units as side chains. The core mannan moiety of the galactomannan was analysed by a sequential NMR assignment method after removing the galactofuranose units by acid treatment. The result indicates that the mannan moiety has a linear repeating structure of alpha1,2-linked mannotetraose units connected by an alpha1,6 linkage. The H-1 signals of the two intermediary alpha1, 2-linked mannoses of the tetraose unit showed a significant upfield shift (Deltadelta=0.05-0.08 p.p.m.), due to the steric effect of an alpha1,6-linked mannose unit. The attachment point of the galactofuranose units was determined at C-3 of the core mannan by the assignment of the downfield-shifted 13C signals of the galactomannan compared with those of the acid-modified product. In these galactomannans there were no polygalactofuranosyl chains which have been found in Penicillium charlesii and Aspergillus fumigatus.
DIURNAL CHANGES IN THE PATTERN OF THE DISTRIBUTION OF GELATINASES AND ASSOCIATED PROTEINS IN TEAR FLUID. EVIDENCE THAT THE PMN CELL IS A MAJOR SOURCE OF MMP ACTIVITY IN NORMAL AND PATHOLOGICAL TEAR FLUID. (2000)

Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts
A proposed data science approach for email spam classification using machine learning techniques (2017)

With the facility of email being accessible to any individual with an internet connection, the proliferation of spam emails is one of the biggest problems which plagues our globally integrated communication systems. The various solutions to filter and hide spam previously included the manual detection of specific keywords and the blacklisting of certain domains created to send spam. However, these methods have certain shortcomings in classifying whether emails are spam or ham. This proposed system attempts to use machine learning techniques to detect a pattern of repetitive keywords which are classified as spam. The system also proposes the classification of emails based on other various parameters contained in their structure such as Cc/Bcc, domain and header. Each parameter would be considered as a feature when applying it to the machine learning algorithm. The machine learning model will be a pre-trained model with a feedback mechanism to distinguish between a proper output and an ambiguous output. This method provides an alternative architecture by which a spam filter can be implemented.
International Assessment of Agricultural Science and Technology for Development (IAASTD) (2009)

ISEE-0479 Background: The IAASTD was an intergovernmental process that focused on the role of agricultural knowledge, science and technology (AKST) in reducing hunger and poverty, improving rural livelihoods and human health, and facilitating environmentally, socially and economically sustainable development. The assessment was published in early 2009. Methods: The IAASTD included a global and five sub-global assessments of the generation, access, dissemination and use of public and private sector AKST, using local, traditional and formal knowledge; existing and emerging technologies, practices, policies and institutions; information needed by decision makers in different civil society, private and public organizations on options for improving policies, practices, institutional and organizational arrangements; and options for future public and private investments in AKST. It brought together a range of stakeholders to share their experiences, views, understanding and vision for the future. Results: Key findings include that AKST has contributed to substantial increases in agricultural production; people benefited unevenly from these yield increases across regions; emphasis on increasing yields and productivity has in some cases had negative consequences on environmental sustainability; global demographic changes and changing patterns of income distribution over the next 50 years are projected to lead to different patterns of food consumption and increased demand for food; a systematic redirection of AKST towards agroecological strategies is needed to address environmental issues; the generation and delivery of AKST needs to be redirected to address a range of persistent socioeconomic inequities; more determined involvement of women's knowledge, skills and experience is required to advance progress towards sustainability and development goals; many of the challenges facing agriculture over the next 50 years will require more integrated applications of existing science and technology; and some challenges may be resolved only by development and application of new and emerging AKST. Conclusion: More information and issue briefs are available at http://www.agassessment.org/.
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses (2018)

Overexpression of hexokinase 2, and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to aerobic glycolysis, which enables them to proliferate. We describe Comp-1, an allosteric small molecule that selectively detaches hexokinase 2 from the mitochondria. Detachment of hexokinase 2 reduces glycolysis and triggers apoptosis in cancer cells, without affecting hexokinase 1-expressing normal cells. The anti-cancer activity of Comp-1 was demonstrated in the UVB-damaged skin model in SKH-1 mice. Topical treatment with Comp-1 led to 70% reduction in lesion number and area. This in vivo efficacy was obtained without local skin reactions or other safety findings. Mechanism-related pharmacodynamic markers, including hexokinase 2 and cleaved caspase 3 levels, are affected by Comp-1 treatment in vivo. Good Laboratory Practice toxicology studies in minipigs for 28 days and 13 weeks established no systemic toxicities and minimal dermal reaction for once-daily application of up to 20% and 15% ointment strengths, respectively. Thus, Comp-1 may address a significant unmet medical need for a non-irritating efficacious topical actinic keratosis treatment.
Genotype Imputation from Large Reference Panels (2018)

Genotype imputation has become a standard tool in genome-wide association studies because it enables researchers to inexpensively approximate whole-genome sequence data from genome-wide single-nucleotide polymorphism array data. Genotype imputation increases statistical power, facilitates fine mapping of causal variants, and plays a key role in meta-analyses of genome-wide association studies. Only variants that were previously observed in a reference panel of sequenced individuals can be imputed. However, the rapid increase in the number of deeply sequenced individuals will soon make it possible to assemble enormous reference panels that greatly increase the number of imputable variants. In this review, we present an overview of genotype imputation and describe the computational techniques that make it possible to impute genotypes from reference panels with millions of individuals.
Flame retardant epoxy resins based on diglycidyloxymethylphenylsilane (2006)

Abstract Silicon‐containing epoxy resins were prepared from diglycidyloxymethylphenyl silane (DGMPS) and diglycidylether of bisphenol A (DGEBA) by crosslinking with 4,4′‐diaminodiphenylmethane (DDM). Several DGMPS/DGEBA molar ratios were used to obtain materials with different silicon contents. Their thermal, dynamomechanical, and flame‐retardant properties were evaluated and related to the silicon content. The weight loss rate of the silicon‐containing resins is lower than that of the silicon free resin. Char yields under nitrogen and air atmospheres increase with the silicon content. The LOI (limited oxygen index) values increased from 24 for a standard commercial resin to 36 for silicon‐containing resins, demonstrating improved flame retardancy. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 5580–5587, 2006
Research on intelligent terminal oriented optimal parking space recommendation model (2014)

In order to deal with the issue of parking space choice in the parking lot, we design an intelligent terminal oriented optimal parking space recommendation model. Based on deeply analyzing users' requirements, the model selects walking distance, driving distance, parking security, type of available parking space, status of available parking spaces and status of the lane as evaluation index. These evaluation indexes are regarded as several properties of each free parking space and used to calculate the optimal parking space. Considering the instantaneity of real-time road traffic status in the parking lot, the whole resources in the parking lot is integrated to dynamically recommend the optimal parking space. In order to describe the implementation model of parking spaces information recommendation and solve the problem of information exchange between systems and users, an optimal parking space recommendation system framework oriented intelligent terminals is designed. Instance validation and analysis shows that the model can dynamically recommend the optimal parking spaces, save the users' parking time and improve the utilization of parking facilities.
Novel method for analysis of printed circuit images (1985)

To keep pace with the trend towards increased circuit integration, printed circuit patterns are becoming denser and more complex. A variety of automated visual inspection methods to detect circuit defects during manufacturing have been proposed. This paper describes a method which is a synthesis of the reference-comparison and the generic-property approaches that exploits their respective strengths and overcomes their respective weaknesses. It is based on the observation that the local geometric and global topological correctness of a printed circuit can be inferred from the correctness of simplified, skeletal versions of the circuit in a test image. These operations can be realized using simple processing elements which are well suited for implementation in hardware.
Silicon micromachined two-dimensional galvano optical scanner (1994)

A new two-dimensional galvano optical scanner realized by silicon micromachining is proposed. To realize two-dimensional operation a silicon micromachined gimbal structure was introduced. It is possible to sense rotational angle using electromagnetic coupling between driving coil and fixed detecting coil.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ballooning-mode stability of bean-shaped cross sections for high-. beta. tokamak plasmas (1983)

Indentation of a tokamak plasma on its inner major radius side is shown to be strongly beneficial for achieving high-..beta.. stability against ballooning modes. Using a set of reasonable equilibrium profiles, it is found that moderate indentation provides accessibility to the second region of stability. Ohmic equilibrium configurations which exhibit the second stability region have not yet been found.
Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release (2011)

We report on the preparation and drug delivery application of shell sheddable micelles based on disulfide-linked star-shaped copolymer of poly(ε-caprolactone) and poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, the micelles exhibit high stability normally and rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity of drug-loaded formulations on tumor cells.
Response Surface Methodology (1996)

(1996). Response Surface Methodology. IIE Transactions: Vol. 28, Scheduling and Logistics, pp. 1031-1032.
Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52 (2012)

The FK506-binding proteins (FKBP) 51 and 52 are cochaperones that modulate the signal transduction of steroid hormone receptors. Both proteins have been implicated in prostate cancer. Furthermore, single nucleotide polymorphisms in the gene encoding FKBP51 have been associated with a variety of psychiatric disorders. Rapamycin and FK506 are two macrocyclic natural products that bind to these proteins indiscriminately but with nanomolar affinity. We here report the cocrystal structure of FKBP51 with a simplified α-ketoamide analogue derived from FK506 and the first structure-activity relationship analysis for FKBP51 and FKBP52 based on this compound. In particular, the tert-pentyl group of this ligand was systematically replaced by a cyclohexyl ring system, which more closely resembles the pyranose ring in the high-affinity ligands rapamycin and FK506. The interaction with FKBPs was found to be surprisingly tolerant to the stereochemistry of the attached cyclohexyl substituents. The molecular basis for this tolerance was elucidated by X-ray cocrystallography.
Investigation of Light Extraction Efficiency in AlGaN Deep-Ultraviolet Light-Emitting Diodes (2013)

Light extraction efficiency (LEE) in AlGaN deep-ultraviolet (DUV) light-emitting diodes (LEDs) is investigated using finite-difference time-domain simulations. For flip-chip and vertical LED structures, LEE is obtained to be <10% due to strong DUV light absorption in the p-GaN layer. In flip-chip LEDs, LEE of transverse-magnetic (TM) modes is found to be more than ten times smaller than that of transverse-electric (TE) modes, which explains the decreasing behavior of external quantum efficiency of DUV LEDs with decreasing wavelength. It is also found that vertical LED structures can have advantages over flip-chip structures for increasing LEE in the TM mode.
Complex rare-earth-substituted lead titanate piezoceramics: II (2005)

Rare earth substituted piezoelectric ceramics with the composition Pb<sub>x</sub>RE<sub>y</sub>Ti<sub>0.98</sub>Mn<sub>0.02</sub>O<sub>3</sub>, with RE = Pr, Pr+Eu, Gd+Nd, and a few percent of bismuth to partially substitute the lead, have been prepared by solid state reaction of oxide powders. Structural and morphological investigations were performed on the poled samples. The uses of high-resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED) have shown the domain structure and the formation of the tetragonal perovskite phase. A non-destructive analysis of the elemental distribution on the surface of the samples has been performed by the electron probe microanalyzer. Samples with diameter 10mm and thickness 1mm have been employed for electrical characterization. Material coefficients have been investigated as a function of temperature. The dielectric permittivity and resistivity were measured for wide temperature and frequency ranges. The Gd+Nd doped PT material has been used to realize a SAW transducer.
J. H. H. Phillips 1913-1987 (1988)

J. H. H. Phillips, retired head of the Entomology Section of the Agriculture Canada Research Station at Vineland Station, Ont., died at his home June 7, 1987, after a long illness. Dr. Phillips had retired in 1974, and had been active in community affairs until he became ill in late 1986.
Deconjugation of Bile Salts by <i>Bacteroides</i> and <i>Clostridium</i> (1981)

Deconjugation of bile salts by four strains of Bacteroides and four strains of Clostridium was studied by use of resting cells and cell-free culture supernatants. Bacteroids strains yielded active cells but showed relatively low bile salt hydrolase (BSH) activity in the culture supernatants while the reverse was the case for the spore-forming clostridial strains. BSH was formed constitutively and was oxygen insensitive. The optimum pH was between 4.5 and 5.0. Marked substrate specificity was found in two strains, one Clostridium and one Bacteroides, which showed restricted activity against taurine conjugates. Bacteroides in general attacked the taurine conjugates of dihydroxy bile acids more readily than the trihydroxy taurine conjugates. Deconjugated bile acid moieties were further modified by some resting cells, depending on the bacterial strain while no enzymatic activity other than that of BSH was found in the culture supernatants. Cells of B. fragilis 2536 performed 7 alpha-dehydrogenation when the pH of the medium allowed the reaction, and this oxidative process was markedly enhanced in the presence of an abundant supply of oxygen as a terminal electron acceptor. C. perfringens PB 6K produced the 3- keto product in addition to the 3 beta-hydroxy derivative of the liberated bile acids and the formation of the latter derivative seemed to take place without preliminary deconjugation.
The Potential of H2O2 as Delignifying and Bleaching Agent. Application to New Bleaching Sequences. (1993)

The major changes occurring in lignin during H2O2 bleaching of mechanical pulp under conventional conditions (70 ; 5% H2O2) were investigated by thioacidolysis. The only detected change was the degradation of some carbonyl groups, likely by the HOO-anion. The main interunit bonds in lignin were left unaffected. As a consequence no delignification is expected when H2O2 is applied on a kraft pulp unless the conditions are modified. Delignification occurred at 90 but the cellulose molecules were damaged. A dramatic improvement was observed when part of the metal ions present in pulp was removed by an EDTA pretreatment. Since at the same time, delignification, brightness and DP of cellulose were increased it is likely that the anion HOO-was still playing a key part in the process. It was shown that H2O2 (P) under these conditions can be advantageously combined with O2 (O) in O/P or O-P type treatments. Bleaching sequences like OPD (D for ClO2) or OPZ (Z for ozone) were investigated.
Techniques for controlling a two-link flexible arm (1990)

The long length and relatively small cross sectional area of the robotic arms envisioned for use inside of the underground nuclear waste storage tanks will require the control of flexible structures. This will become an important problem in the characterization and remediation of these tanks. We are developing control strategies to actively damp residual vibrations in flexible robotic arms caused by high speed motion and abrupt external forces. A planar, two-link flexible arm is currently being used to test these control strategies. In this paper, two methods of control are discussed. The first is a minimum-time control approach which utilizes a finite element model and and optimization program. These tools plan the motor torque profiles necessary for the tip of the arm to move along a straight line, in minimum time, within the motors' torque constraints, and end in a quiescent state. To account for modeling errors in the finite element model, errors in joint angles, velocities, and link curvatures are added to the optimal torque trajectory. Linear quadratic Gaussian (LQG) regulatory design theory is used to determine the feedback gains. The second method of control is a teleoperated joystick controller which uses an input shaping technique to alter the commands of the joystick so as to reduce the residual vibration of the fundamental modes. Approximating the system as linear, the natural frequency and damping ratio are estimated on-line for the complete system, which includes the structure plus a lower level proportional derivative controller. An input shaping filter is determined from the estimated natural frequency, estimated damping ratio, and the desired transfer function of the system. 11 reps., 9 figs.
Observation of <i>p</i> <i>n</i> junctions on implanted silicon using a scanning tunneling microscope (1988)

Si pn junctions fabricated by photoresist masked As+ implantation were observed using current imaging tunneling spectroscopy (CITS) in a scanning tunneling microscope (STM). Using the CITS, a specific bias was chosen to define n-type or p-type areas according to whether or not current flowed. The pn junctions could be easily identified from the current image at this bias and in the STM topographic image. It also proved possible to find processing faults related to implantation. The STM images also identified the structure (corrugations) near the junctions, associated with volume expansion caused by implantation and annealing.
Structure and development of meat animals. (1984)

Structure and development of meat animals , Structure and development of meat animals , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Low power GaAs digital ICs using Schottky diode-FET logic (1978)

A logic circuit approach for GaAs ICs, which makes use of high speed GaAs Schottky barrier diodes for most of the logic functions, will be described. Low power depletion-mode GaAs FETs are used principally for logic inversion and gain.
State-plane trajectories used to observe and control the behavior of a voltage step-up DC-DC converter (1976)

State-plane analysis techniques are employed to study the voltage step-up energy-storage dc-to-dc converter. Within this framework, an example converter operating under the influence of a constant on-time and a constant frequency controller is examined. Qualitative insight gained through this approach is used to develop a conceptual free-running control law for the voltage step-up converter which can achieve steady-state operation in one on/off cycle of control. Digital computer simulation data is presented to illustrate and verify the theoretical discussions presented.