gebhart/patrepeval huggingface dataset:
Interactions fonctionnelles entre la voie de signalisation du TGF-β par les Smads et le TNF-α implications dans la régulation de l'expression du collagène de type I (2005)

The balance between production and degradation of type I collagen plays a critical role in the development and maintenance of organ and tissue integrity. Its also represents the most crucial element governing the process of tissue repair. TGF-beta, a key player in the physiopathology of tissue repair, enhances type I collagene gene expression. In contrast, TNF-alpha, whose matrix-remodelling function is opposite to that of TGF-beta, reduces type I collagen gene expression. This review focuses on transcriptional regulation of type I collagen by TGF-beta and TNF-alpha, and on the molecular mechanisms that control the antagonistic activity of TNF-alpha against TGF-beta-driven type I collagen gene expression.
On Building Immersive Audio Applications Using Robust Adaptive Beamforming and Joint Audio-Video Source Localization (2006)

This paper deals with some of the different problems, strategies, and solutions of building true immersive audio systems oriented to future communication applications. The aim is to build a system where the acoustic field of a chamber is recorded using a microphone array and then is reconstructed or rendered again, in a different chamber using loudspeaker array-based techniques. Our proposal explores the possibility of using recent robust adaptive beamforming techniques for effectively estimating the original sources of the emitting room. A joint audio-video localization method needed in the estimation process as well as in the rendering engine is also presented. The estimated source signal and the source localization information drive a wave field synthesis engine that renders the acoustic field again at the receiving chamber. The system performance is tested using MUSHRA-based subjective tests.
Alternating current calorimetry of dimyristoylphosphatidylcholine multilayers: hysteresis and annealing near the gel to liquid-crystal transition (1981)

The gel to liquid-crystal phase transition in dimyristoylphosphatidylcholine liposomes was studied with 0.4-Hz ac calorimetry. The ac heat capacity on heating scans exhibited a peak in the vicinity of 23.9 degrees C with a full width at half-maximum of 0.15-0.20 degrees C. The enthalpy change was 4.8 kcal/mol, in good agreement with conventional differential scanning calorimetry. On cooling scans, the peak shifted to lower temperature by 0.1-0.5 degrees C, the width increased to 0.25-0.40 degrees C, and the apparent enthalpy change was only 40% of that observed on heating. Both the heating and cooling heat capacities were stable for at least 20 min in quasi-isothermal conditions. Following a 1 h anneal at 10 degrees C, the heating scans were quite reproducible. The results have been interpreted in terms of the nucleation and subsequent annealing of small ordered domains in the bilayer on freezing the acyl chains. No peak associated with the pretransition was observed, as expected since the relaxation time for the degrees of freedom the produce the pretransition is much longer than the period of the 0.4-Hz temperature wave.
The Time Lag in Diffusion (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Time Lag in DiffusionH. L. FrischCite this: J. Phys. Chem. 1957, 61, 1, 93–95Publication Date (Print):January 1, 1957Publication History Published online1 May 2002Published inissue 1 January 1957https://pubs.acs.org/doi/10.1021/j150547a018https://doi.org/10.1021/j150547a018research-articleACS PublicationsRequest reuse permissionsArticle Views2596Altmetric-Citations261LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Online parameter optimization for elastic data stream processing (2015)

Elastic scaling allows data stream processing systems to dynamically scale in and out to react to workload changes. As a consequence, unexpected load peaks can be handled and the extent of the overprovisioning can be reduced. However, the strategies used for elastic scaling of such systems need to be tuned manually by the user. This is an error prone and cumbersome task, because it requires a detailed knowledge of the underlying system and workload characteristics. In addition, the resulting quality of service for a specific scaling strategy is unknown a priori and can be measured only during runtime.
Learning human behavioral profiles in a cyber environment (2010)

Fast and efficient delivery of targeted and personalized advertisements has become a staple in E-commerce. The field of market research targeting in online environments has seen extensive research on the topic of customer targeting, but most of the information detailing the process of profiling is closely guarded by the industry. Much of what is available tells that information such as cookies and browsing history are used to target customers, associating keywords with specific groups of inventory. We designed and conducted a web-based shopping experiment with fifty participants to observe how people of different backgrounds and experiences make decisions. The experiment investigates whether or not it is possible to learn repeatable patterns of behavior through data mining techniques to determine the profile of an online shopper solely based upon outside observation. Our results suggest that by recording the actions taken and time spent on each decision, one may be able to use statistical models to discern demographic information such as gender and infer connections between the shopper and the gift recipient. This brings optimism to the idea that by examining action data and the target of the actions, our methods could be used to determine the identities of online shoppers. Further, these methods could be tested in other online environments to determine identities, in cases such as online fraud or other issues related to cyber security.
New two-point scleral-fixation technique for foldable intraocular lenses with four hollow haptics (2016)

The study was to report a new two-point scleral-fixation technique for foldable intraocular lenses with four haptics. Lenses were slid into the anterior chamber from a 2.8 mm corneal incision and fixed under two sclera flaps at two opposite points. The postoperative best-corrected visual acuities (BCVAs) of all patients were significantly better than their preoperative BCVA. The results demonstrate that two-point, scleral fixations of foldable, intraocular lenses might be practicable and effective.
A student-designed automotive collision avoidance system (1978)

A receiver-transmitter system at 99 MHz is energized by a shock activated switch to provide warnings of collision, emergency vehicles, or other road hazards. The system was designed and constructed as part of a senior design sequence. It was intended to be simple and reliable, and, when translated into modern integrated circuit technology, it can be installed at a low cost per vehicle. It provides advantages over radar braking in that it is practically feasible and much less expensive. It has advantages over other approaches in that it can be used in the daytime or at night and in any weather.
Tropical Rain Mapping Radar On The Space Station (2005)

The conceptual design for a tropical rain mapping radar for flight on the manned Space Station is discussed. In this design the radar utilizes a narrow, dual-frequency (9.7 GHz and 24.1 GHz) beam, electronically scanned antenna to achieve high spatial (4 km) and vertical (250 m) resolutions and a relatively large (800 km) cross-track swath. An adaptive scan strategy will be used for better utilization of radar energy and dwell time. Such a system can detect precipitation at rates of up to 100 mm/hr with accuracies of roughly 15 percent. With the proposed space-time sampling strategy, the monthly averaged rainfall rate can be estimated to within 8 percent, which is essential for many climatological studies.
Reconstructing hand kinematics during reach to grasp movements from electroencephalographic signals (2011)

With continued research on brain machine interfaces (BMIs), it is now possible to control prosthetic arm position in space to a high degree of accuracy. However, a reliable decoder to infer the dexterous movements of fingers from brain activity during a natural grasping motion is still to be demonstrated. Here, we present a methodology to accurately predict and reconstruct natural hand kinematics from non-invasively recorded scalp electroencephalographic (EEG) signals during object grasping movements. The high performance of our decoder is attributed to a combination of the correct input space (time-domain amplitude modulation of delta-band smoothed EEG signals) and an optimal subset of EEG electrodes selected using a genetic algorithm. Trajectories of the joint angles were reconstructed for metacarpo-phalangeal (MCP) joints of the fingers as well as the carpo-metacarpal (CMC) and MCP joints of the thumb. High decoding accuracy (Pearson's correlation coefficient, r) between the predicted and observed trajectories (r = 0.76 ± 0.01; averaged across joints) indicate that this technique may be suitable for use with a closed-loop real-time BMI to control grasping motion in prosthetics with high degrees of freedom. This demonstrates the first successful decoding of hand pre-shaping kinematics from noninvasive neural signals.
The lipopolysaccharide of Legionella pneumophila serogroup 1 (strain Philadelphia 1): chemical structure and biological significance. (1995)

The lipopolysaccharide (LPS, endotoxin) of Legionella pneumophila serogroup 1 (Philadelphia 1) exhibits peculiar chemical features which may account for its importance as a bacterial virulence factor. The O-chain of this LPS constitutes a homopolymer of an unusual sugar, 5-acetamidino-7-acetamido-8-O-acetyl-3,5,7, 9-tetradeoxy-D-glycero-L-galacto-nonulosonic acid (legionaminic acid) of which about 10-75 residues are present. Due to the lack of free hydroxyl groups, this homopolymer renders the cell surface highly hydrophobic and, therefore, supports adherence to the membrane of target cells including alveolar macrophages. Investigations of the serological specificity of the serogroup 1 LPS revealed a monoclonal antibody (mAb 3/1) which recognizes an epitope located in the environment of the 8-O-acetyl group of legionaminic acid. According to epidemiological studies, this determinant appears to be associated with L. pneumophila virulence. The outer core oligosaccharide of L. pneumophila LPS exhibits also hydrophobic properties due to the presence of N- and O-acetyl groups as well as 6-deoxy sugars. The inner core expresses both similarities and differences as compared to enterobacterial core oligosaccharides in containing Kdo but lacking heptose and phosphate groups. Lipid A possesses some unique structural features since its backbone consists of a bisphosphorylated beta-GlcpN3N-(1-->6)-GlcpN3N disaccharide with only amide-linked acyl groups having 14-22 carbon atoms. Long chain fatty acids [28:0(27-oxo) and 27:0-dioic] possessing the double length as enterobacterial acyl groups, may be responsible for the low endotoxicity of L. pneumophila lipid A.
Mixed‐mode ion‐exchangers and their comparative chromatographic characterization in reversed‐phase and hydrophilic interaction chromatography elution modes (2008)

A set of particulate silica-supported mixed-mode RP/weak anion-exchangers (RP/WAX) (obtained by bonding of N-undecenoylated 3-aminoquinuclidine, 3-aminotropane and 2-dimethylaminoethylamine as well as of N-butenoyl-(2S,4S,5R)-2-aminomethyl-5-[(2-octylthio)ethyl]-quinuclidine to thiol-modified silica) were chromatographically characterized in comparison to selected commercially available columns using two distinct isocratic elution modes, viz. an aqueous-rich RP-type elution mode (with 40% ACN and 60% buffer) as well as an organic solvent-rich hydrophilic interaction chromatography (HILIC)-type elution mode (95 and 90% ACN). The mixed-mode RP/WAX phases showed multimodal applicability, unlike a polar embedded RP material (Synergi Fusion RP), amino phases (Luna NH(2), BioBasic AX) or typical HILIC packings (ZIC-HILIC, TSKGel Amide-80). Principal component analysis (PCA) of the RP test data confirmed that the in-house developed RP/WAX columns as well as the Acclaim Mixed-Mode WAX-1 phase resemble each other in their chromatographic characteristics having slightly lower hydrophobic selectivity (alpha(CH2) of 1.5) than the tested Synergi Fusion RP (alpha(CH2) approximately 1.8). In contrast, a decrease in mixed-mode character due to lowered ion-exchange capacity and concomitantly increased RP-like behavior could be identified for other mixed-mode phases in the order of Obelisc R > Primesep B2 > Uptisphere MM3. PCA on HILIC data revealed that the RP/WAX phases behave dissimilar to TSKGel Amide-80, ZIC-HILIC and polysulfoethyl A under the chosen elution conditions. Hence, they may be regarded as complementary to these commercial stationary phases with applicability profiles for hydrophilic but also hydrophobic solutes.
Dendritic Modulation of Burst-Like Firing in Sensory Neurons (2001)

This report describes the variability of spontaneous firing characteristics of sensory neurons, electrosensory lateral line lobe (ELL) pyramidal cells, within the electrosensory lateral line lobe of weakly electric fish in vivo. We show that these cells' spontaneous firing frequency, measures of spike train regularity (interspike interval coefficient of variation), and the tendency of these cells to produce bursts of action potentials are correlated with the size of the cell's apical dendritic arbor. We also show that bursting behavior may be influenced or controlled by descending inputs from higher centers that provide excitatory and inhibitory inputs to the pyramidal cells' apical dendrites. Pyramidal cells were classified as "bursty" or "nonbursty" according to whether or not spike trains deviated significantly from the expected properties of random (Poisson) spike trains of the same average firing frequency, and, in the case of bursty cells, the maximum within-burst interspike interval characteristic of bursts was determined. Each cell's probability of producing bursts above the level expected for a Poisson spike train was determined and related to spontaneous firing frequency and dendritic morphology. Pyramidal cells with large apical dendritic arbors have lower rates of spontaneous activity and higher probabilities of producing bursts above the expected level, while cells with smaller apical dendrites fire at higher frequencies and are less bursty. The effect of blocking non-N-methyl-D-aspartate (non-NMDA) glutamatergic synaptic inputs to the apical dendrites of these cells, and to local inhibitory interneurons, significantly reduced the spontaneous occurrence of spike bursts and intracellular injection of hyperpolarizing current mimicked this effect. The results suggest that bursty firing of ELL pyramidal cells may be under descending control allowing activity in electrosensory feedback pathways to influence the firing properties of sensory neurons early in the processing hierarchy.
Microfluidic flow control on charged phospholipidpolymer interface (2006)

A type of charged phospholipid polymer biointerface was constructed on a quartz microfluidic chip to control the electroosmotic flow (EOF) and to suppress non-specific protein adsorption through one-step modification. A negatively charged phospholipid copolymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC), n-butyl methacrylate (BMA), potassium 3-methacryloyloxypropyl sulfonate (PMPS) and 3-methacryloxypropyl trimethoxysilane (MPTMSi) moieties (referred to as PMBSSi) was synthesized to introduce such phosphorylcholine segments as well as surface charges onto the silica-based microchannels via chemical bonding. At neutral pH, the homogenous microchannel surface modified with 0.3 wt% PMBSSi in alcoholic solution, retained a significant cathodic EOF ((1.0 +/- 0.1) x 10(-4) cm(2) V(-1) s(-1)) with approximately one-half of the EOF of the unmodified microchannel ((1.9 +/- 0.1) x 10(-4) cm(2) V(-1) s(-1)). Along with another non-charged copolymer (poly(MPC-co-MPTMSi), PMSi), the regulation of the surface charge density can be realized by adjusting the concentration of PMBSSi or PMSi initial solutions for modification. Coincidently, the zeta-potential and the EOF mobility at neutral pH showed a monotonically descending trend with the decrease in the charge densities on the surfaces. This provides a simple but feasible approach to controlling the EOF, especially with regard to satisfying the requisites of miniaturized systems for biological applications requiring neutral buffer conditions. In addition, the EOF in microchannels modified with PMBSSi and PMSi could maintain stability for a long time at neutral pH. In contrast to the EOF in the unmodified microchannel, the EOF in the modified microchannel was only slightly affected by the change in pH (from 1 to 10). Most importantly, although PMBSSi possesses negative charges, the non-specific adsorptions of both anionic and cationic proteins (considering albumin and cytochrome c, respectively, as examples) were effectively suppressed to a level of 0.15 microg cm(-2) and lesser in the case of the 0.3 wt% PMBSSi modification. Consequently, the variation in the EOF mobility resulting from the protein adsorption was also suppressed simultaneously. To facilitate easy EOF control with compatibility to biomolecules delivered in the microfluidic devices, the charged interface described could provide a promising option.
Nest Building as an Indicator of Health and Welfare in Laboratory Mice (2013)

The minimization and alleviation of suffering has moral and scientific implications. In order to mitigate this negative experience one must be able to identify when an animal is actually in distress. Pain, illness, or distress cannot be managed if unrecognized. Evaluation of pain or illness typically involves the measurement of physiologic and behavioral indicators which are either invasive or not suitable for large scale assessment. The observation of nesting behavior shows promise as the basis of a species appropriate cage-side assessment tool for recognizing distress in mice. Here we demonstrate the utility of nest building behavior in laboratory mice as an ethologically relevant indicator of welfare. The methods presented can be successfully used to identify thermal stressors, aggressive cages, sickness, and pain. Observation of nest building behavior in mouse colonies provides a refinement to health and well-being assessment on a day to day basis.
Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia (2018)

By examining alpha7 nicotinic receptor biology and recent efforts to target the receptor in clinical trials, it is hoped that investigators will be motivated to explore novel, promising directions focusing on the receptor as a strategy to treat cognitive symptoms in schizophrenia.
A Fast Feature Extraction System on Compressed Audio Data (2008)

An efficient system is described, which directly extracts features from compressed audio material. It consists of a time/frequency conversion method and a feature extraction algorithm. The conversion method provides the feature extraction algorithm with a suitable complex spectral representation directly from the compressed domain. It further allows to trade-off between computational complexity and conversion accuracy. Several operating points using different conversion accuracies were tested with an MPEG audio identification system in order to evaluate the identification confidence. Based on these results it is possible to reduce the computational complexity from O(N log N) to O(N) compared to the conventional approach (complete decoding followed by a frequency analysis).
Quantification of collateral blood flow in coarctation of the aorta by velocity encoded cine magnetic resonance imaging. (1994)

This study shows the normal flow pattern in the descending thoracic aorta and its reversal in coarctation due to collateral flow. Thus, VENC-MR can measure collateral flow in coarctation and serves as a unique method for providing this important measurement of the severity of coarctation of the aorta.
<i>gfp</i> -Based <i>N</i> -Acyl Homoserine-Lactone Sensor Systems for Detection of Bacterial Communication (2001)

In order to perform single-cell analysis and online studies of N-acyl homoserine lactone (AHL)-mediated communication among bacteria, components of the Vibrio fischeri quorum sensor encoded by luxR-P(luxI) have been fused to modified versions of gfpmut3* genes encoding unstable green fluorescent proteins. Bacterial strains harboring this green fluorescent sensor detected a broad spectrum of AHL molecules and were capable of sensing the presence of 5 nM N-3-oxohexanoyl-L-homoserine lactone in the surroundings. In combination with epifluorescent microscopy, the sensitivity of the sensor enabled AHL detection at the single-cell level and allowed for real-time measurements of fluctuations in AHL concentrations. This green fluorescent AHL sensor provides a state-of-the-art tool for studies of communication between the individuals present in mixed bacterial communities.
Using Citation Data to Improve Retrieval from MEDLINE (2005)

Objective: To determine whether algorithms developed for the World Wide Web can be applied to the biomedical literature in order to identify articles that are important as well as relevant.
An interference-aware 5.8GHz wake-up radio for ETCS (2012)

Wake-up radios have been a popular transceiver architecture in recent years for battery-powered applications such as wireless body area networks (WBANs) [1], wireless sensor networks (WSNs) [2,3], and even electronic toll collection systems (ETCS) [4]. The most important consideration in implementing a wake-up receiver (WuRX) is low power dissipation while maximizing sensitivity. Because of this requirement of very low power, WuRX are usually designed by a simple RF envelope detector (RFED) consisting of Schottky diodes [1,3] or MOSFETs in the weak inversion region [2] without active filtering or amplification of the input signal. Therefore, the performance of the RFED itself is critical for attaining good sensitivity of the WuRX. Moreover, the poor filtering of the input signal renders the WuRX vulnerable to interferers from nearby terminals with high transmit power such as mobile phones and WiFi devices, and this can result in false wake-ups [1]. Although the RFED has very low power, a false wake-up will increase the power consumption of the wake-up radio as it will enable the power-hungry main transceiver.