gebhart/patrepeval huggingface dataset:
Systematic evaluation of distribution of transgene expression after adenovirus-mediated gene transfer to the transplanted heart (1998)

In the transplantation setting, the study and potential treatment of acute and chronic rejection by means of gene therapy will require widespread transgene expression in the donor organ. The distribution of transgene expression after adenovirus-mediated gene transfer via the coronary vasculature in a model of abdominal heterotopic heart transplantation in syngeneic rats (n = 6) was evaluated at 1 week. Reporter gene expression was evenly distributed in the base, the midventricle, and the apex of the transplanted hearts. This study demonstrates that intracoronary administration of the adenoviral vector to the donor heart results in widespread transgene expression.
High Density Ultra-Thin Organic Substrates for Advanced Flip Chip Packages (2019)

Advanced semiconductor packaging requirements for higher and faster performance in a thinner and smaller form factor continue to grow for mobile, network and consumer devices. While the increase in device input/output (I/O) density is driven by the famous “Moore's Law”, the packaging industry is experiencing opposing trends for more complex packaging solutions while the expected cost targets are moving in a downward direction. Fine line/space is one of the key requirements for high I/O count packages where die-to-die or die-to-memory integration is needed. Si based inorganic interposers have typically been used in this area for the last few years. However, Si interposers are expensive and supply chain issues can be a serious bottleneck. Although there are few organic interposer solutions in the market, none of these solutions addressed clearly the entire needs of flip chip packages. Demand for high-speed flip chip packages creates an opportunity for highly integrated, multi-chip modules (MCM's) and 2.5D/3D silicon (Si) interposer packages. These packages are emerging very slowly due to the higher costs often associated with infrastructure and supply chain challenges that can happen before a technology is mature. Achieving both increased margins in the power delivery and increased functionality in next generation high-speed applications requires extremely efficient, low loss package designs with an ultra-thin core or coreless substrate with fine line and space. As the substrate gets thinner, it becomes very flexible and one of the biggest assembly challenges for ultra-thin coreless substrates is to keep the substrate flat during the assembly process while still maintaining yield targets. Other issues with thin substrates are related to post assembly such as handling, long-term package reliability and functionality in the application field. The work presented in this paper describes key factors for mitigating several assemblies related issues in the manufacturing line, including package warpage/coplanarity, and selecting the optimum processes and materials for the ultra-thin coreless substrate, called uFOS (Ultra Format Organic Substrate), for flip chip packages with high assembly yields and lower cost. uFOS potential application spaces including die-todie and package-to-package using 2.5D or 2.1D (embedded high-density film or eHDF) methods will be explored using an ultra-thin coreless substrate as an interposer, as opposed to the traditional Si interposer. Various pros and cons along with relative cost data will be discussed. Several design of experiments (DOE) for ultra-thin substrates are being carried out to achieve the objective of the work. Multiple test vehicles have been designed using a flip chip package with an ultra-thin coreless buildup substrate utilizing various assembly materials and processes. The detailed process and some reliability data will be published. More work will be carried out to expand the scope of the technology for multi-chip module (MCM) die and 2.5D integration. Some initial eHDF data will be published as well.
Non contiguous-finished genome sequence and description of Dielma fastidiosa gen. nov., sp. nov., a new member of the Family Erysipelotrichaceae (2013)

Dielma fastidiosa strain JC13(T) gen. nov., sp. nov. is the type strain of D. fastidiosa gen. nov., sp. nov., the type species of a new genus within the family Erysipelotrichaceae. This strain, whose draft genome is described here, was isolated from the fecal flora of a healthy 16-year-old male Senegalese volunteer. D. fastidiosa is a Gram-negative anaerobic rod. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 3,574,031 bp long genome comprises a 3,556,241-bp chromosome and a 17,790-bp plasmid. The chromosome contains 3,441 protein-coding and 50 RNA genes, including 3 rRNA genes, whereas the plasmid contains 17 protein-coding genes.
Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site. (1991)

Phospholipase A2 (PLA2), EC 3.1.1.4, which catalyzes the release of free fatty acids from the sn-2 position of glycerophospholipids, has been extensively studied from the viewpoint of eicosanoid production (Arita, H., Nakano, T., and Hanasaki, K. (1989) Prog. Lipid Res. 28, 273-301). Several lines of evidence suggest that extracellular PLA2 is pathophysiologically related to some disorders, including inflammation and hypersensitivity. Despite this, little is known of the precise mechanism of the pathological processes as well as their intrinsic correlation with dysfunction. Here, we report a novel PLA2 action on the proliferation of Swiss 3T3 fibroblasts via specific binding sites of approximately Mr 200,000. Pancreatic type PLA2 in the active form specifically recognized the sites and stimulated thymidine incorporation in DNA. Its inactive zymogen and other PLA2s from platelets, snake, and bee venoms showed much lesser activities. Although the physiological significance remains to be identified, our finding is the first to offer a new viewpoint on the effect of mammalian extracellular PLA2 on cellular function.
<title>Tomographic imaging of radar data gathered on a circular flight path about a three-dimensional target zone</title> (1995)

We have coded a tomographic-style algorithm that is capable of imaging radar data obtained on a circular flight path about a 3D target zone. Our imaging algorithm is designed to image field data collected with Mireage's new Subsurface Imaging Synthetic Aperture Radar (SISAR), a ground-penetrating device operating in the spotlight mode. The SISAR algorithm operates on radar data gathered in (or converted to) the range-azimuth domain--the so-called sinogram plane. On the sinogram plane, the impulse response of a point scatterer is sinewave- shaped curve. The amplitude of the sinewave is related to the target's radial coordinate, its phase to the target's azimuthal coordinate, and its bias to the target's burial depth. When flown on a circular path about a 3D target zone, SISAR generates 3D-style sinograms. Our imaging algorithm produces 3D maps of the target zone by converting each sinewave trace on the sinogram plane to a delta function in three-space. The code is fast (in the FFT sense). Moreover, it avoids the laborious, and often inaccurate conversion of the collected radar data from cylindrical coordinates to rectangular ones, as in conventional radar imaging.
ChemInform Abstract: Magnesium Chloride Directed Aldol Reaction and Bromination of 2‐Acetylfuran. (1988)

Abstract In order to obtain pure monobrominated 2‐acetylfuran (II) instead of a mixture of (II) and the dibrominated compound (III), (I) is treated with Huenig's base and magnesium chloride before bromination.
Improving Surface Hole Air-Foam Drilling Performance in Karstified Limestone (Papua New Guinea) (2010)

Abstract Drilling in The Highlands of Papua New Guinea is very challenging. The surface topography is extremely mountainous, with deep gorges and razoiback ridges. In addition, the Darai Limestone outcrops at surface and is karstified to a depth often in excess of 1,500 m, with the presence of underground rivers and caverns being common. The subsurface geology is even more complex with steeply dipping formations (at times near vertical), faults, and inverted sequences where the geological strata have been overturned by folding. Well pads are constructed by flattening off the top of a mountain ridge or peak. Drilling from these elevated locations provides additional hydrostatic head to reduce the mud weight required in high-pressure formations encountered deeper in the well. Well pad construction is extremely costly but is more economic from peaks than from valley bottoms. Valley bottom locations often do not provide sufficient hydrostatic pressure head to maintain well control in deep, high-pressure formations without having to use excessively high mud weights. The Darai Limestone is drilled with an air-foam mixture, as 100% lost circulation is typical. The karstification of this formation makes it unstable and prone to rubble collapse and mobile sediment packoffs.
Satellite recognition and pose estimation using homeomorphic manifold analysis (2015)

We propose a novel monocular vision-based framework for both satellite recognition and pose estimation, using homeomorphic manifold analysis. We use a unified conceptual manifold to represent continuous pose variation of all satellites in the visual input space, learn nonlinear function mapping from conceptual manifold representation to visual inputs, and decompose discrete category variation in the mapping coefficient space. Experimental results on a simulated image data set show the effectiveness and robustness of our approach.
Radiation therapy for chest wall recurrence of breast cancer after mastectomy in a favorable subgroup of patients (1998)

Treatment for a local-regional recurrence of breast cancer after mastectomy in a favorable subgroup of patients results in a high rate of long-term survival as well as excellent local control. Aggressive treatment is warranted in this favorable subgroup of patients.
Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation (1998)

The mechanisms by which growth factor-induced signals are propagated to the nucleus, leading to the activation of the transcription factor CREB, have been characterized. Nerve growth factor (NGF) was found to activate multiple signaling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133 (Ser-133). NGF activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs), which in turn activate the pp90 ribosomal S6 kinase (RSK) family of Ser/Thr kinases, all three members of which were found to catalyze CREB Ser-133 phosphorylation in vitro and in vivo. In addition to the ERK/RSK pathway, we found that NGF activated the p38 MAPK and its downstream effector, MAPK-activated protein kinase 2 (MAPKAP kinase 2), resulting in phosphorylation of CREB at Ser-133. Inhibition of either the ERK/RSK or the p38/MAPKAP kinase 2 pathway only partially blocked NGF-induced CREB Ser-133 phosphorylation, suggesting that either pathway alone is sufficient for coupling the NGF signal to CREB activation. However, inhibition of both the ERK/RSK and the p38/MAPKAP kinase 2 pathways completely abolished NGF-induced CREB Ser-133 phosphorylation. These findings indicate that NGF activates two distinct MAPK pathways, both of which contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes.
Risk of preterm delivery with increasing depth of excision for cervical intraepithelial neoplasia in England: nested case-control study (2014)

The risk of preterm birth is at most minimally affected by a small excision. Larger excisions, particularly over 15 mm or 2.66 cm(3), are associated with a doubling of the risk of both preterm and very preterm births. The risk does not decrease with increasing time from excision to conception. Efforts should be made to excise the entire lesion while preserving as much healthy cervical tissue as possible. Close obstetric monitoring is warranted for women who have large excisions of the cervical transformation zone.
Matthew Arnold and the Eighteenth Century (1940)

Criticism, as Arnold conceived it, fastened primarily on great men and great works. But the estimilte of Arnold's criticism has rested too heavily upon what he has said of such men and such works: attention has been withdrawn from his many fruitful generalizations on the connection between an individual writer and the age in which he lives, the tradition to which he subscribes, the movements against which he rebels. To think in terms of movements was by no means alien to Arnold's mind: whenever he occupied himself, as he often did, with works of secondary worth or with writers incompletely expressive, he set in the foreground the definition and estimation of movements. Much of his most illuminating criticism is found in passages where movements are his over-riding interest.
Explaining turn-taking constraints using a traditional conversation analysis approach in cross-examination courtroom interaction (2014)

A Conversation Analysis (CA) approach is used to analyse the interactional practices of question-answer frameworks used in the courtroom case of ‘The Murder Trial’ whereby cameras were allowed in the High Court in Edinburgh to capture a trial in its entirety.\nTalk in the courtroom comes under a sub-heading of institutionalised talk, whereby courtroom \n“interaction is merely a neutral medium through which attorneys, witnesses, judges, and jurors determine what the facts are and how the law applies” (Heritage & Clayman, 2010, p.173). This linguistic and sequential pattern of interaction showcases the court’s own dynamic structures and rules that bring about turn-taking constraints that are embedded within the talk to construct individualised goals of guilt or innocence.\nThis paper investigates the defence lawyer’s cross-examination questioning techniques which are addressed to the witness by looking at transitions in speakership between turn-taking constraints to see how agendas are designed, and in turn project a constraining answer from the witness in the institutionalised order of question-answer phenomena, (Atkinson & Drew, 1979; Drew, 2002). For example, the witness is allowed little or no flexibility in giving their evidence; instead they are inhibited and guided by institutionalised frameworks, (Atkinson & Drew, 1979; Danet & Bogoch, 1980; Drew, 1992; Heritage & Clayman, 2010; Matoesian, 1993). \nHeritage & Clayman, (2010), suggest that “talk alone does not make verdicts of guilt or innocence determinative”, (p.185), yet demonstrates how talk needs to instead be invoked and analysed to see how such language practices shape the decisions of what is talked about and how it serves to shape the conversational goal of each interlocutor.
Joint Transceiver Design for MIMO Channel Shortening (2007)

Channel shortening equalizers can be employed to shorten the effective impulse response of a long intersymbol interference (ISI) channel in order, for example, to decrease the computational complexity of a maximum-likelihood sequence estimator (MLSE) or to increase the throughput efficiency of an orthogonal frequency-division multiplexing (OFDM) transmission scheme. In this paper, the issue of joint transmitter-receiver filter design is addressed for shortening multiple-input multiple-output (MIMO) ISI channels. A frequency-domain approach is adopted for the transceiver design which is effectively equivalent to an infinite-length time-domain design. A practical space-frequency waterfilling algorithm is also provided. It is demonstrated that the channel shortening equalizer designed according to the time-domain approach suffers from an error-floor effect. However, the proposed techniques are shown to overcome this problem and outperform the time-domain channel shortening filter design. We also demonstrate that the proposed transceiver design can be considered as a MIMO broadband beamformer with constraints on the time-domain multipath length. Hence, a significant diversity gain could also be achieved by choosing strong eigenmodes of the MIMO channel. It is also found that the proposed frequency-domain methods have considerably low computational complexity as compared with their time-domain counterparts.
Exponential Dependence of the Interlayer Exchange Coupling on the Spacer Thickness in MBE-grown Fe/SiFe/Fe Sandwiches (1997)

The structure and interlayer exchange coupling in MBE-grown Fe/SiFe/Fe has been investigated. From structural analysis with LEED and from magnetic analysis with the magneto-optical Kerr effect, it is concluded that the Si spacer transforms into an ordered ${\mathrm{Si}}_{0.5}{\mathrm{Fe}}_{0.5}$ alloy. A strong antiferromagnetic coupling is found (maximum $\ensuremath{-}2.0\mathrm{mJ}/{\mathrm{m}}^{2}$), the strength of which varies exponentially as a function of the spacer thickness. This behavior can be explained within the framework of recent coupling theories.
Modulating the Transport Characteristics of Bruch's Membrane With Steroidal Glycosides and its Relevance to Age-Related Macular Degeneration (AMD) (2015)

Transport characteristics of human Bruch's can be improved by ginsenosides, facilitating the bidirectional exchange of nutrients and waste products across the membrane. With improved transport pathways, the need for supplement therapies becomes redundant. Slowed aging of Bruch's is expected to delay the onset and/or progression of AMD.
WDM PON based on spectrum-sliced fiber amplifier light source (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text D. K. Jung, S. K. Shin, C. -. Lee, and Y. C. Chung, "WDM PON based on spectrum-sliced fiber amplifier light source," in Optical Networks and Their Applications, R. Barry, ed., Vol. 20 of OSA Trends in Optics and Photonics (Optica Publishing Group, 1998), paper SS5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Progressive Batch Medical Image Retrieval Processing in Mobile Wireless Networks (2015)

This article addresses a multi-query optimization problem for distributed medical image retrieval in mobile wireless networks by exploiting the dependencies in the derivation of a retrieval evaluation plan. To the best of our knowledge, this is the first work investigating batch medical image retrieval (BMIR) processing in a mobile wireless network environment. Four steps are incorporated in our BMIR algorithm. First, when a number of retrieval requests (i.e., m retrieval images and m radii) are simultaneously submitted by users, then a cost-based dynamic retrieval ( CDRS ) scheduling procedure is invoked to efficiently and effectively identify the correlation among the retrieval spheres (requests) based on a cost model. Next, an index-based image set reduction ( ISR ) is performed at the execution-node level in parallel. Then, a refinement processing of the candidate images is conducted to get the answers. Finally, at the transmission-node level, the corresponding image fragment (IF) replicas are chosen based on an adaptive multi-resolution ( AMR )-based IF replicas selection scheme, and transmitted to the user-node level by a priority-based IF replicas transmission ( PIFT ) scheme. The experimental results validate the efficiency and effectiveness of the algorithm in minimizing the response time and increasing the parallelism of I/O and CPU.
Iron‐Catalyzed Coupling of Aryl Grignard Reagents with Alkyl Halides: A Competitive Hammett Study (2011)

Competing for electrophiles: The elusive iron-catalyzed CC coupling reaction was investigated and analyzed by a Hammett study of the nucleophilic partner. This required finding conditions in which the iron catalyst is stable in the presence of an excess of the Grignard reagent. The selectivity-determining step seems to be the transmetalation, occurring either before or after the oxidative addition step (see scheme).
Advanced Ovarian Adenocarcinoma A Prospective Clinical Trial of Melphalan (L-PAM) Versus Combination Chemotherapy (1979)

Young, Robert C.; Chabner, Bruce A.; Hubbard, Susan P.; Fisher, Richard I.; Bender, Richard A.; Anderson, Tom; Simon, Richard M.; Canellos, George P.; Devita, Vincent T. Jr. Author Information
Phenoxazine-Based Conjugated Polymers:  A New Class of Organic Semiconductors for Field-Effect Transistors (2005)

Five new phenoxazine-based conjugated polymers, including poly(10-hexylphenoxazine-3,7-diyl), poly(10-hexylphenoxazine-3,7-diyl-alt-9,9-dihexyl-2,7-fluorene), and poly(10-hexylphenoxazine-3,7-diyl-alt-3-hexyl-2,5-thiophene), were synthesized, characterized, and successfully used as p-channel semiconductors in organic field-effect transistors. The polymers have high glass transition temperatures in the 112−230 °C range. The phenoxazine-based polymers have low ionization potentials or high-lying HOMO levels (4.8−4.9 eV), which were estimated from cyclic voltammetry. Organic field-effect transistors based on the phenoxazine polymer semiconductors have a field effect hole mobility of up to 6 × 10-4 cm2/(V s) and an on/off ratio of up to 104. These results demonstrate that phenoxazine-based conjugated polymers are promising p-type semiconductors for solution processable thin film transistors.
Design, machine synthesis, and NMR-solution structure of a β-heptapeptide forming a salt-bridge stabilised 314-helix in methanol and in water (2001)

Salt-bridge formation may be used to stabilise the 314-helical conformation of β-peptides in aqueous solution, as shown by a 2D-NMR spectroscopic investigation.
Suture needle drainage of subretinal fluid. (1993)

A simple technique is described for the transcleral drainage of subretinal fluid during retinal detachment repair. In a prospective study of 94 consecutive suture needle drainage procedures subretinal fluid was successfully drained in 91 cases. There were six 'significant' subretinal haemorrhages associated with the procedure, but none was subfoveal in location or directly compromised the surgical outcome. In no case was retinal incarceration or retinotomy observed.
Biologically Relevant Chemical Reactions of N7-Alkylguanine Residues in DNA (2004)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTBiologically Relevant Chemical Reactions of N7-Alkylguanine Residues in DNAKent S. Gates, Tony Nooner, and Sanjay DuttaView Author Information Departments of Chemistry and Biochemistry, University of MissouriColumbia, Columbia, Missouri 65211 Cite this: Chem. Res. Toxicol. 2004, 17, 7, 839–856Publication Date (Web):June 26, 2004Publication History Received19 January 2004Published online26 June 2004Published inissue 1 July 2004https://pubs.acs.org/doi/10.1021/tx049965chttps://doi.org/10.1021/tx049965creview-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views1651Altmetric-Citations214LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Genetics,Guanine,Lesions,Ring opening reactions Get e-Alerts