gebhart/patrepeval huggingface dataset:
Regulation of Stem Cell Pluripotency and Differentiation Involves a Mutual Regulatory Circuit of the Nanog, OCT4, and SOX2 Pluripotency Transcription Factors With Polycomb Repressive Complexes and Stem Cell microRNAs (2009)

Coordinated transcription factor networks have emerged as the master regulatory mechanisms of stem cell pluripotency and differentiation. Many stem cell-specific transcription factors, including the pluripotency transcription factors, OCT4, NANOG, and SOX2 function in combinatorial complexes to regulate the expression of loci, which are involved in embryonic stem (ES) cell pluripotency and cellular differentiation. This review will address how these pathways form a reciprocal regulatory circuit whereby the equilibrium between stem cell self-renewal, proliferation, and differentiation is in perpetual balance. We will discuss how distinct epigenetic repressive pathways involving polycomb complexes, DNA methylation, and microRNAs cooperate to reduce transcriptional noise and to prevent stochastic and aberrant induction of differentiation. We will provide a brief overview of how these networks cooperate to modulate differentiation along hematopoietic and neuronal lineages. Finally, we will describe how aberrant functioning of components of the stem cell regulatory network may contribute to malignant transformation of adult stem cells and the establishment of a "cancer stem cell" phenotype and thereby underlie multiple types of human malignancies.
Consequences of Superovulation and ART Procedures (2012)

Superovulation procedures and assisted reproductive technologies (ART) have provided the means for significant improvement in infertility care. Although generally safe, these procedures are associated with complications that, albeit rare, can have significant morbidity. Complications from superovulation include ovarian hyperstimulation syndrome, thromboembolism, and adnexal torsion. Complications from oocyte retrieval include infection, bleeding, bowel injury, and anesthetic complications. Early pregnancy complications from in vitro fertilization include multiple gestations, ectopic pregnancy, and heterotopic pregnancy. Stimulation, retrieval, and transfer techniques can be modified to minimize these risks and prevent complications. Further research in the field is needed to continue to improve the safety of superovulation and ART.
Instrumental measurement and control of colour (1988)

In spite of the fact that the basic method of colour measurement was established more than harf a centuy ago, it is only during the last fifteen years that the application of colour measurement is particularly substantial and significant because of the advancement of computer technology, better understanding of colour science, and the revolution in equipment design. This has brought colour science from a scientific exercise in the research laboratory to a widely used industrial and commercial tool. The present state of the art of colour measurement is such that an analogy can be made to the measurement of linear dimensions at one time by the relatively crude yardstick, but now replaced by the precisely scaled micrometer. Thus with colour measurement now, colour can be measured with a precision unmatched by the human eye. To‐day, both the colorant industry and colour dependent commerce (industries such as dyes, textiles, pigments, cosmetics, coatings, paper, plastics etc.) are taking advantage of such techniques since the economic advantages are quite substantial. Furthermore, the techniques involved are, to a large extent, no longer trade secrets. The literature abounds with practical theories and concepts which can be applied directly in the workplace by competent colourists. It is expected that more applications of colour measurement for similar general usage are being developed. This paper is designed to introduce the fundamental concept of colour science and various types of colour measuring instruments and their selection. The value of these colour measuring instruments for practical use in industry and commerce is discussed. Finally, the sources of the technical information and assistance are given.
Concomitant administration of GonaCon™ and rabies vaccine in female dogs (Canis familiaris) in Mexico (2013)

Mexico serves as a global model for advances in rabies prevention and control in dogs. The Mexican Ministry of Health (MMH) annual application of approximately 16 million doses of parenteral rabies vaccine has resulted in significant reductions in canine rabies during the past 20 years. One collateral parameter of rabies programs is dog population management. Enhanced public awareness is critical to reinforce responsible pet ownership. Surgical spaying and neutering remain important to prevent reproduction, but are impractical for achieving dog population management goals. GonaCon™, an anti-gonadotropin releasing hormone (GnRH) vaccine, was initially tested in captive female dogs on the Navajo Nation, 2008. The MMH led this international collaborative study on an improved formulation of GonaCon™ in captive dogs with local representatives in Hidalgo, Mexico in 2011. This study contained 20 bitches assigned to Group A (6 control), Group B (7 GonaCon™), and Group C (7 GonaCon™ and rabies vaccine). Vaccines were delivered IM. Animals were placed under observation and evaluated during the 61-day trial. Clinically, all dogs behaved normally. No limping or prostration was observed, in spite of minor muscle atrophy post-mortem in the left hind leg of dogs that received GonaCon™. Two dogs that began the study pregnant give birth to healthy pups. Dogs that received a GonaCon™ injection had macro and microscopic lesions consistent with prior findings, but the adverse injection effects were less frequent and lower in intensity. Both vaccines were immunogenic based on significant increases in rabies virus neutralizing antibodies and anti-GnRH antibodies in treatment Groups B and C. Simultaneous administration of GonaCon™ and rabies vaccine in Group C did not affect immunogenicity. Progesterone was suppressed significantly in comparison to controls. Future studies that monitor fertility through multiple breeding cycles represent a research need to determine the value of integrating this vaccine into dog rabies management.
Polymer/carbon nanotube composite emulsion prepared through ultrasonically assisted in situ emulsion polymerization (2006)

Abstract In this study, ultrasonic irradiation and in situ emulsion polymerization were combined to prepare stable poly(methyl methacrylate‐ co ‐ n ‐butyl acrylate) (P(MMA‐BA))/carbon nanotubes (CNTs) composite emulsion, which solves the dispersion problem of CNTs in the latex. Two stages were adopted. In Stage I, ultrasonically initiated in situ emulsion polymerization was conducted to disperse CNTs and prepare the seed emulsion containing polymer coated CNTs. In Stage II, conventional in situ emulsion polymerization was conducted to further enhance the monomer conversion and solid content. The dispersion behavior of MWCNTs in aqueous solution under ultrasonic irradiation was investigated by spectrophotometry. The effects of CNTs content on the emulsion stability and mechanical properties of composite film were studied. The results suggest that in the composite emulsion the long CNTs with a diameter of 20–40 nm are separated and dispersed by the formed polymer latex nanoparticles with a size of 20–40 nm. The spherical polymer latex nanoparticles adhere to the wall of CNTs to form a structure like “grapes on the twig.” The smooth, uniform, and flexible polymer/CNTs composite films were prepared from the composite emulsion. The CNTs can be individually dispersed in P(MMA‐BA)/CNTs composite film. Tensile tests suggest that with the increase in the CNTs content, the Young's modulus and the yield strength of the film increase. Only at 1 wt % CNTs, the Young's modulus increases from 124 to 289 MPa, and the yield strength is improved about ∼14%. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 3123–3130, 2006
A Case of Gastric Emphysema with Portal Vein Emphysema associated with the Episode of Severe Vomiting (2005)

Gastric emphysema is rare but it has a fulminant course with high mortality rate. We report a 58-year old man who visited the emergency room because of severe vomiting and nausea which had started 2 days ago. He underwent curative pylorus-preserving pancreaticoduodenectomy due to ampullary cancer 4 months ago. He was diagnosed as gastric emphysema with combined portal vein emphysema. Only with conservative treatment such as intravenous fluids infusion and decompression of the stomach by nasogastric tube, the condition of the patient slowly improved. The patient was able to discharge without surgical intervention.
Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease (2012)

Tamibarotene (Am80), a synthetic retinoid approved in Japan for treatment of acute promyelocytic leukemia (APL), is a retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. Am80 is considered to be a promising candidate drug for treatment of Alzheimer's disease (AD) because of its transcriptional controls of multiple target genes involved in etiology and pathology of AD. In APP23 AD model mice, administration of Am80 decreased the deposition of insoluble amyloid-β(42). In senescence-accelerated mice (SAMP8), Am80 ameliorated the decrease of cortical acetylcholine, as well as reducing anxiety in behavioral tests and improving the sleep deficit. Am80 also effected a significant improvement of memory in the rat scopolamine-induced memory deficit model. Like other retinoids, Am80 also has an immunomodulatory effect and reduces secretion of proinflammatory cytokines and chemokines by astrocytes and microglia surrounding amyloid-β plaques. In a rat experimental autoimmune encephalomyelitis model, Am80 reduced inflammatory cytokines and showed significant efficacy. Retinoids also promote differentiation of neural stem cells, and Am80 improved the recovery of spinal cord-injured rats. Am80 may also improve vascular factors involved in onset and/or progression of AD. Am80 has been in clinical use for treatment of APL in Japan since 2005, and has been reported to have fewer side effects than other retinoids. We have recently started a clinical study to evaluate the efficacy and safety of Am80 for the treatment of Alzheimer's disease.
Quantization noise reduction using multiphase PLLs (2006)

A 120 MHz fractional-N frequency synthesizer was implemented in a standard 0.18mum CMOS process with an on-chip multiphase voltage-controlled oscillator (VCO). The proposed architecture uses multiphase outputs of the VCO to decrease quantization noise from the sigma-delta (SigmaDelta) modulator. Results show the decrease in quantization noise from the 4th order SigmaDelta is 6dB for every two fold increase in the number of phases. The VCO phase noise was measured to be -104 dBc/Hz at 200 kHz offset. The loop bandwidth can be increased to 700 kHz and still maintain in-band quantization noise below -200 dBc/Hz. The power consumption of the synthesizer is 5.4 mW with a 1.8 V supply and it occupies an active area of 750 mum times 550 mum. The intended application is subharmonic injection higher frequency VCO and as a clock generator in a subsampling analog-to-digital converter (ADC)
The attenuated Towne strain of human cytomegalovirus may revert to both endothelial cell tropism and leuko- (neutrophil- and monocyte-) tropism in vitro (2002)

The Towne strain of human cytomegalovirus (HCMV), originally recovered from the urine of a congenitally infected newborn, was attenuated through 125 passages in human embryonic lung fibroblast cell cultures. Although reliable markers of attenuation were not identified, the virus was shown to be attenuated by inoculation of both healthy human volunteers and immunocompromised patients. More recently, Towne (like other laboratory-adapted strains) was shown not to have two biological properties typical of recent clinical isolates: endothelial cell tropism and polymorphonuclear leukocyte tropism. These markers of attenuation are lost by all clinical isolates on extensive propagation in cell cultures and are apparently associated with one another. Here, we show that Towne may reacquire both endothelial cell tropism and leuko- (polymorphonuclear- and monocyte-) tropism on adaptation to growth in endothelial cell cultures. However, reversion to endothelial cell tropism is dissociated from reversion to leukotropism, since the latter was reacquired 10-20 passages later. Thus, these two biological properties, which were considered to be encoded by the same viral gene(s), appear to be distinct. Both restriction fragment length polymorphism and Southern blot analysis demonstrated the identity of the attenuated and endothelial cell tropic variants of Towne, thus suggesting that only minor variations (mutations) of the viral genome may be responsible for loss or reacquisition of the two biological properties. Viral genes involved in endothelial cell tropism and leukotropism remain to be identified. However, reversion of attenuated strains to pathogenicity in vivo cannot be excluded a priori.
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review) (2015)

The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.
Disseminated Microsporidiosis Due to Encephalitozoon hellem: Pulmonary Colonization, Microhematuria, and Mild Conjunctivitis in a Patient with AIDS (1993)

Four genera of microsporidia have been associated with disease in humans, which predominantly affects immunocompromised persons. Systemic infection with a newly characterized microsporidian species, Encephalitozoon hellem, was recently reported in a patient with AIDS. This article describes a second patient with AIDS and disseminated E. hellem infection. In this case the parasite was detected in sputum, urine, and conjunctival swab specimens. Apart from recurrent mild conjunctivitis and asymptomatic microhematuria, the patient had no findings or symptoms that could be related to this parasite. Specifically, no microsporidian-associated pulmonary pathology was documented. Detection of E. hellem in the patient's sputum may have epidemiological implications in that this finding suggests transmission of microsporidia by the aerosol route. Because the patient died of unrelated complications, it remains unknown whether he was an asymptomatic carrier of microsporidia or whether microhematuria heralded early microsporidian disease, with the onset of cellular damage in the urinary tract.
Second-harmonic-generation microscope with a microlens array scanner (2002)

We propose a multifocus scanning technique in second-harmonic-generation (SHG) microscopy in which the SHG detection efficiency and the image acquisition rate are improved by several tens of times compared with typical single-focus scanning techniques. Because of a microlens array scanner, the laser beam of a mode-locked Ti:sapphire laser is split into ~100 beamlets, and the same number of foci are formed in the specimen. Parallel scanning of the foci enables us to observe real-time images of the specimen. The imaging properties and the usefulness of the microscope are demonstrated by SHG images of living HeLa cells and rat cardiac myocytes.
Collimator design for experimental minibeam radiation therapy (2011)

A minibeam collimator setup was created, which can deliver a 30 Gy peak dose minibeam radiation therapy treatment at depths less than 1 cm with a valley-to-peak dose ratio on the order of 23%.
A coupled analysis method for structures with independently modelled finite element subdomains (1995)

Abstract A new method for analysing plate and shell structures with two or more independently modelled finite element subdomains is presented, assessed, and demonstrated. This method provides a means of coupling local and global finite element models whose nodes do not coincide along their common interface. In general, the method provides a means of coupling structural components (e.g., wing and fuselage) which may have been modelled by different analysts. In both cases, the need for transition modelling, which is often tedious and complicated, is eliminated. The coupling is accomplished through an interface for which three formulations are considered and presented. These formulations are: collocation, discrete least‐squares, and hybrid variational. Several benchmark problems are analysed and it is shown that the hybrid variational formulation provides the most accurate solutions.
Artful systems in the home (2005)

In this paper we introduce the idea of organizing systems. Through a number of examples from an ongoing ethnographic study of family life, we suggest that organizing systems come about through the artful design and use of informational artifacts in the home, such as calendars, paper notes, to-do lists, etc. These systems are not only seen to organize household routines and schedules, but also, crucially, to shape the social relations between family members. Drawing attention to the material properties of informational artifacts and how assemblies of these artifacts come to make up organizing systems, we discuss some general implications for designing information technology for the home. Most importantly, we suggest that technologies must be designed to accommodate the rich and diverse ways in which people organize their homes, providing them with the resources to artfully construct their own systems rather than enforcing ones that are removed from their own experiences.
A maximum-likelihood method for estimating thresholds in a yes–no task (1993)

A maximum-likelihood procedure for estimating threshold values in a yes-no task is presented. In computer simulations of this procedure, it is demonstrated that the variability of the threshold estimates is little affected by the density of the hypotheses tested for a fixed range, or by serious misestimates of the slope of the psychometric functions. The threshold value is also largely independent of the starting value of the signal. The standard deviation of the threshold estimates appears to decrease with the square root of the number of trials, with a 2- to 3-dB standard deviation possible if only 12 trials are used in the threshold estimates. Data are presented using human listeners tested on 5 days. Two threshold estimates, based on 12 trials, were made at each of the six audiometric frequencies on each day. The mean data appear sensible, and the standard deviation of the measured thresholds is about 3 dB. Using this procedure, it takes less than 3 min to measure the audiogram for a single ear.
Degradation of Graphene by Hydrogen Peroxide (2014)

Degradation of graphene by H2O2 at physiologically and environmentally relevant concentrations (1–10 000 × 10−6m) is reported. Exposure to H2O2 leads to the formation of holes on graphene sheets. The degradation phenomenon is dependent on concentration of H2O2 and incubation time.
Optimal trajectory generation in ocean flows (2005)

In this paper it is shown that Lagrangian Coherent Structures (LCS) are useful in determining near optimal trajectories for autonomous underwater gliders in a dynamic ocean environment. This opens the opportunity for optimal path planning of autonomous underwater vehicles by studying the global flow geometry via dynamical systems methods. Optimal glider paths were computed for a 2-dimensionaI kinematic model of an end-point glider problem. Numerical solutions to the optimal control problem were obtained using Nonlinear Trajectory Generation (NTG) software. The resulting solution is compared to corresponding results on LCS obtained using the Direct Lyapunov Exponent method. The velocity data used for these computations was obtained from measurements taken in August, 2000, by HF-Radar stations located around Monterey Bay, CA, USA.
<i>In vivo</i>visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging (2009)

Because macrophages play a key role on host defense, visualization of the migration of these cells is of high relevance for both diagnostic purposes and the evaluation of therapeutic interventions. The present article addresses the use of iron oxide and gadolinium-based particles for the noninvasive in vivo detection of macrophage infiltration into inflamed areas by magnetic resonance imaging (MRI). A general introduction on the functions and general characteristics of macrophages is followed by a discussion of some of the agents and acquisition schemes currently used to track the cells in vivo. Attention is then devoted to preclinical and clinical applications in the following disease areas: atherosclerosis and myocardial infarction, stroke, multiple sclerosis, rheumatoid arthritis, and kidney transplantation.
No apparent involvement of the FMR1 gene in five patients with phenotypic manifestations of the fragile X syndrome (1994)

Most fragile X patients have a significant increase in the number of CGG repeats in the FMR1 gene. Two patients were described with a deletion and one patient with a point mutation in the FMR1 gene. We describe 5 patients with a fragile X or Martin-Bell phenotype. Two brothers were discordant for the region containing the FMR1 gene; if there is a common cause for the mental retardation this is not located in the FMR1 gene. In the other 3 patients the expression of the FMR1 gene was found to be normal and no abnormalities were noted in the FMR1 mRNA. No amplification was found in the GCC repeat which is associated with the fragile site FRAXE. We conclude that the Martin-Bell phenotype can also be caused by mutations outside the FMR1 gene.