gebhart/patrepeval huggingface dataset:
Cocaine and HIV-1 Interplay in CNS: Cellular and Molecular Mechanisms (2012)

Although antiretrovirals are the mainstay of therapy against HIV infection, neurological complications associated with the virus continue to hamper quality of life of the infected individuals. Drugs of abuse in the infected individuals further fuel the epidemic. Epidemiological studies have demonstrated that abuse of cocaine resulted in acceleration of HIV infection and the progression of NeuroAIDS. Cocaine has not only been shown to play a crucial role in promoting virus replication, but also has diverse but often deleterious effects on various cell types of the CNS. In the neuronal system, cocaine exposure results in neuronal toxicity and also potentiates gp120-induced neurotoxicity. In the astroglia and microglia, cocaine exposure leads to up-regulation of pro-inflammatory mediators such as cytokines and chemokines. These in turn, can lead to neuroinflammation and transmission of toxic responses to the neurons. Additionally, cocaine exposure can also lead to leakiness of the blood-brain barrier that manifests as enhanced transmigraiton of leukocytes/monocytes into the CNS. Both in vitro and in vivo studies have provided valuable tools in exploring the role of cocaine in mediating HIV-associated neuropathogenesis. This review summarizes previous studies on the mechanism(s) underlying the interplay of cocaine and HIV as it relates to the CNS.
Improved fidelity of triggered entangled photons from single quantum dots (2006)

We demonstrate the on-demand emission of polarisation-entangled photon pairs from the biexciton cascade of a single InAs quantum dot embedded in a GaAs/AlAs planar microcavity. Improvements in the sample design blue shifts the wetting layer to reduce the contribution of background light in the measurements. Results presented show that >70% of the detected photon pairs are entangled. The high fidelity of the (|HxxHx>+|VxxVx>)/2^0.5 state that we determine is sufficient to satisfy numerous tests for entanglement. The improved quality of entanglement represents a significant step towards the realisation of a practical quantum dot source compatible with applications in quantum information.
The Dictionary of Psychology (2016)

With more than three times as many defined entries, biographies, illustrations, and appendices than any other dictionary of psychology ever printed in the English language, Raymond Corsini's Dictionary of Psychology is indeed a landmark resource. The most comprehensive, up-to-date reference of its kind, the Dictionary also maintains a user-friendliness throughout. This combination ensures that it will serve as the definitive work for years to come. With a clear and functional design, and highly readable style, the Dictionary offers over 30,000 entries (including interdisciplinary terms and contemporary slang), more than 125 illustrations, as well as extensive cross-referencing of entries. Ten supportive appendices, such as the Greek Alphabet, Medical Prescription Terms, and biographies of more than 1,000 deceased contributors to psychology, further augment the Dictionary's usefulness. Over 100 psychologists as well as numerous physicians participated as consulting editors, and a dozen specialist consulting editors reviewed the material. Dr. Alan Auerbach, the American Psychological Association's de facto dictionary expert, served as the senior consulting editor. As a final check for comprehensiveness and accuracy, independent review editors were employed to re-examine, re-review, and re-approve every entry.
Patterns of cytokeratin expression in the epithelia of inflamed human gingiva and periodontal pockets (1993)

Fourteen specimens of periodontal pockets and the associated marginal gingiva were collected and either frozen for examination using antibodies against various defined cytokeratin specificities or processed for 2-dimensional gel electrophoresis. The epithelium forming the pocket lining typically extended into the connective tissue of the pocket wall in the form of a network of finger-like strips. Immunocytological staining indicated that keratins (K) 5, 6, 14 and 19 were expressed by almost all cells of the pocket lining and K13 and K16 by the suprabasal cells. The coronal region of the pocket lining showed some cells staining for K4. Staining for K8 and K18 was seen in the apical region of the pocket lining and in the finger-like extensions of epithelium into the connective tissue. Compared with normal gingiva, the sulcular and the oral gingival epithelia showed a marked increase in staining for K19. Surprisingly, the pattern of keratin expression of the epithelium of the pocket lining was found to be essentially similar to that of normal junctional epithelium and the anatomical position of the boundaries between each epithelial phenotype were not significantly altered. These patterns of keratin expression were confirmed by the 2D electrophoretic analyses of microdissected regions of epithelium. The potential significance of inflammation to the epithelial changes associated with pocket formation is discussed.
Addressing the Fouling of In Situ Ultraviolet-Visual Spectrometers Used to Continuously Monitor Water Quality in Brackish Tidal Marsh Waters (2013)

The introduction of portable in situ ultraviolet-visual spectrometers has made possible the collection of water quality parameters at a high frequency in dynamic systems such as tidal marshes. The usefulness of this technology is inhibited by fouling of the instrument's optics. In this study, a spectrometer fitted with manufacturer-recommended compressed air optical cleaning was installed in a brackish marsh to determine if fouling interfered with measurements between bi-weekly servicing. During a 2-wk period, the absorbance measured in air at 220 nm increased from 9 to 549 m, indicating major fouling. An antifouling system was developed that reduced the time of exposure of the optics to stream water and used a pressurized fresh water cleaning. After implementation of the system, the absorbance in air increased to at most 63 m after 2 wk of data collection. The dramatic reduction in fouling will allow quality long-term data to be collected using this technology.
The Lysine Requirement of the Growing Boar versus Barrow (1984)

Five experiments were conducted to determine if boars and barrows differ in the level of dietary lysine required to maximize growth rate, efficiency of feed utilization, carcass leanness and N retention. In Exp. 1, 48 boars and 48 barrows were fed fortified corn-soybean meal diets calculated to contain 14 (grower) and 12% protein (finisher) and supplemented with 0, .15 or .30% lysine from 27 to 105 kg body weight. The basal diets analyzed .60 and .47% lysine, respectively. Linear improvements in feed/gain (P less than .01), backfat thickness (P less than .10), longissimus muscle area (P less than .01), and ham-loin (P less than .05) and lean cuts percentage (P less than .1) were observed in boars as dietary lysine increased. In barrows, however, growth rate, feed:gain ratio and carcass characteristics (except longissimus muscle area) were not significantly affected by dietary lysine level. In Exp. 2, 18 boars and 18 barrows initially averaging 64 kg body weight were fed a 12% protein diet (.47% lysine) supplemented with 0, .15 or .30% lysine. Linear (P less than .05) increases in N retention occurred in boars, but not barrows, as dietary lysine was increased. In Exp. 3 and 4, 140 boars (34 to 103 kg) were fed a 14-12% protein sequence (analyzed .61 and .48% lysine) supplemented with 0, .1, .2, .3 or .4% lysine. In Exp. 5, 60 boars (23 to 103 kg) were fed a 16-14% protein sequence (analyzed .83 and .68% lysine) supplemented with 0, .075, .15 or .225% lysine.(ABSTRACT TRUNCATED AT 250 WORDS)
Total Synthesis of Resveratrol‐Based Natural Products: A Chemoselective Solution (2007)

Despite the attention paid to resveratrol (1) owing to its potent biological activity, little effort has been devoted to studying resveratrol-based oligomers (such as 2–4). The first general synthetic approach is outlined for accessing the carbogenic diversity possessed by this family of compounds. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703333_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Pre- and Post-Launch Spatial Quality of the Landsat 8 Thermal Infrared Sensor (2015)

The Thermal Infrared Sensor (TIRS) for the Landsat 8 platform was designed and built at NASA Goddard Space Flight Center (GSFC). TIRS data will extend the data record for thermal observations from the heritage Landsat sensors, dating back to the launch of Landsat 4 in 1982. The two-band (10.9 and 12.0 μm) pushbroom sensor with a 185 km-wide swath uses a staggered arrangement of quantum well infrared photodetector (QWIPs) arrays. The required spatial resolution is 100 m for TIRS, with the assessment of crop moisture and water resources being science drivers for that resolution. The evaluation of spatial resolution typically relies on a straight knife-edge technique to determine the spatial edge response of a detector system, and such an approach was implemented for TIRS. Flexibility in the ground calibration equipment used for TIRS thermal-vacuum chamber testing also made possible an alternate strategy that implemented a circular target moved in precise sub-pixel increments across the detectors to derive the edge response. On-orbit, coastline targets were developed to evaluate the spatial response performance. Multiple targets were identified that produced similar results to one another. Even though there may be a slight bias in the point spread function (PSF)/modulation transfer function (MTF) estimates towards poorer performance using this approach, it does have the ability to track relative changes for monitoring long-term instrument status. The results for both pre- and post-launch response analysis show general good agreement and consistency with edge slope along-track values of 0.53 and 0.58 pre- and post-launch and across-track values 0f 0.59 and 0.55 pre- and post-launch.
Central Pulse Pressure and Mortality in End-Stage Renal Disease (2002)

Damage of large arteries is a major factor in the high cardiovascular morbidity and mortality of patients with end-stage renal disease (ESRD). Increased aortic pulse wave velocity (PWV) and brachial pulse pressure (PP) are the principal arterial markers of cardiovascular mortality described in these patients. Whether central (carotid) PP and brachial-carotid PP amplification may predict all-cause (including cardiovascular) mortality has never been investigated. A cohort of 180 patients with ESRD who were undergoing hemodialysis was studied between January 1990 and March 2000. The mean duration of follow-up was 52+/-36 months (mean+/-SD). Mean age at entry was 51.5+/-16.3 years. Seventy deaths occurred, including both cardiovascular and noncardiovascular fatal events. At entry, patients underwent carotid PP measurements (pulse wave analysis), echocardiography, and aortic PWV (Doppler ultrasonography), together with standard clinical and biochemical analyses. On the basis of Cox analyses, after adjustment of age, time on dialysis before inclusion, and previous cardiovascular events, 3 factors emerged as predictors of all-cause mortality: carotid PP, brachial/carotid PP, and aortic PWV. Adjusted hazard ratios for 1-SD increments were 1.4 (1.1 to 1.8) for carotid PP, 0.5 (0.3 to 0.8) for brachial/carotid PP, and 1.3 (1.0 to 1.7) for PWV. Brachial blood pressure, including PP, had no predictive value for mortality after adjustment. These results provide the first direct evidence that in patients with ESRD, the carotid PP level and, mostly, the disappearance of PP amplification are strong independent predictors of all-cause (including cardiovascular) mortality.
Methods for autofluorescence analysis of uterine cavity washings (2015)

The diagnostics of endometrial pathology can be done by obtaining information at the molecular level, e. g. using the autofluorescence-based technique. Thus, for the first time an experimental study was performed on waste material of uterine cavity washing specimens to evaluate suitability of the technique for diagnostics. The specimens were obtained from 32 patients who had a conventional uterine hydrosonography procedure. A portable Nd:YAG 355 nm microlaser was used to excite autofluorescence at the point of care. Various algorithms of multivariate curve resolution and artificial neural networks were utilized for spectra analysis. The spectra were classified according to histological and ultrasound diagnosis. Receiver operating characteristic (ROC) curve analysis was used to make statistical decisions. The results showed that it was possible to distinguish all compared groups: pathologic vs non-pathologic endometrium (sensitivity 97.3 ± 5.2%, specificity 91.7 ± 7%, AUC (area under the ROC curve) 0.96 ± 0.04), malignant endometrium vs endometrial polyps (sensitivity 100 ± 0%, specificity 92.0 ± 10.6%, AUC = 0.98 ± 0.07), and secretory menstrual cycle phase vs proliferative phase (sensitivity 87.5 ± 13.2%, specificity 94.4 ± 7.4%, AUC = 0.88 ± 0.10). To conclude, uterine cavity washing specimens could be used for endometrial pathology recognition using the autofluorescencebased technique in clinical setting. It will possibly speed up the treatment decision making for endometrial pathology.
Supplementary Material for: MicroRNA miR-371a-3p - A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid (2016)

<br><strong><em>Background:</em></strong> microRNAs (miRs)-371-3 are suggested to be novel biomarkers of germ cell tumors (GCTs), but their specificity is unresolved. We aimed at clarifying the origin of miR 371a-3p by measuring this miR in peripheral vein blood, and in fluids present in the vicinity of GCTs. <b><i>Methods:</i></b> miR-371a-3p levels were measured by quantitative PCR in 9 tumor surrounding hydroceles and in cubital vein blood (CVB) and testicular vein blood (TVB) of 64 GCT patients, 51 with clinical stage (CS) 1, 13 with CS2-3. Thirty three CS1 cases had also postoperative CVB measurement. TVB miR levels were compared with those of CVB. Associations with clinical factors were analyzed statistically. <b><i>Results:</i></b> TVB miR levels were 294-fold, 80-fold and 4.6-fold higher than those in CVB of CS1 patients, CS2-3 patients and controls, respectively. Neoplastic hydrocele fluid comprised of very high miR levels. In CS1, miR levels dropped to normal postoperatively. Statistically, CVB miR levels are significantly associated with tumor size (p = 0.0211) and testis length (p = 0.0493). TVB miR levels are associated with testis length (p = 0.0129). <b><i>Conclusions:</i></b> This study provides evidence for the origin of circulating miR 371a-3p molecules from GCT cells. miR-371a-3p represents a specific serum biomarker for germ cell cancer.
The biliproteins of the Cryptophyceae (1989)

The absorption spectra of the biliprotein pigments from 26 cryptomonad strains (Cryptophyceae), representing probably 23 species, have been examined. Twenty of these strains were isolated from Australian waters. Sixteen species are shown to possess Cr-phycoerythrins that can be allotted to the three types of this pigment previously distinguished on the basis of absorption maxima. The remaining seven species possess Cr-phycocyanins, exhibiting four distinct absorption spectra. The system of classification of the Cr-phycocyanins, including a novel fourth type, is reviewed. A correlation between the distribution of the biliproteins and the genera of Cryptophyceae is discussed.
Comparison of ring artifact correction methods for flat-detector CT (2009)

In flat-detector CT, imperfect or defect detector elements may cause concentric ring artifacts due to their continuous over- or underestimation of attenuation values, which often disturb image quality. Especially due to the demand for high-spatial resolution images and the necessary pixel read-out without arbitrary pixel-binning, ring artifacts become more pronounced and the reduction of these artifacts becomes a necessity. We here present a comparison of two dedicated ring artifact correction methods for flat-detector CT, on the basis of different median and mean filterings of the reconstructed image but each working in different geometric planes. While the first method works in Cartesian coordinates, the second method performs a transformation to polar coordinates. Both post-processing methods efficiently reduce ring artifacts in the reconstructed images and improve image quality. The transformation to polar coordinates turned out to be a necessary step for efficient ring artifact correction, since correction in Cartesian coordinates suffers from newly introduced artifacts as well as insufficient correction of artifacts close to the center of rotation.
Measurement of Refractive Error in Native American Preschoolers: Validity and Reproducibility of Autorefraction (2000)

C-Autoref provided reliable and valid measurements of refractive error in young children. NC-Autoref measurements were reliable within subjects, but there was large variability in validity among subjects.
Detection of Autophagy in <i>Caenorhabditis elegans</i> Using <i>GFP::LGG-1</i> as an Autophagy Marker (2016)

In yeast and mammalian cells, the autophagy protein Atg8/LC3 (microtubule-associated proteins 1A/1B light chain 3B encoded by MAP1LC3B) has been the marker of choice to detect double-membraned autophagosomes that are produced during the process of autophagy. A lipid-conjugated form of Atg8/LC3B is localized to the inner and outer membrane of the early-forming structure known as the phagophore. During maturation of autophagosomes, Atg8/LC3 bound to the inner autophagosome membrane remains in situ as the autophagosomes fuse with lysosomes. The nematode Caenorhabditis elegans is thought to conduct a similar process, meaning that tagging the nematode ortholog of Atg8/LC3-known as LGG-1-with a fluorophore has become a widely accepted method to visualize autophagosomes. Under normal growth conditions, GFP-modified LGG-1 displays a diffuse expression pattern throughout a variety of tissues, whereas, when under conditions that induce autophagy, the GFP::LGG-1 tag labels positive punctate structures, and its overall level of expression increases. Here, we present a protocol for using fluorescent reporters of LGG-1 coupled to GFP to monitor autophagosomes in vivo. We also discuss the use of alternative fluorescent markers and the possible utility of the LGG-1 paralog LGG-2.
Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits (1991)

A reduction in nerve blood flow in chronic experimental diabetes has been linked to impaired conduction. Recently, there have been reports that this is preceded by a period of functional hyperemia. The present investigation explored early changes in sciatic nerve endoneurial blood flow and function in streptozocin-treated rats with durations of diabetes from 1 wk to 4 mo. Blood flow was monitored by microelectrode polarography and hydrogen clearance in thiobutabarbital (Inactin)-anesthetized animals. It was reduced by 41% as early as 1 wk after diabetes induction. There was no evidence of an early functional hyperemia, flow remaining 44% depressed up to 4 mo. In another investigation, similar reductions in blood flow were acutely induced in normal rats rendered hyperglycemic by glucose infusion. In diabetic animals, conduction velocity in sciatic branches supplying gastrocnemius and tibialis anterior muscles was correlated with blood flow. The link was further tested using a group of 2-mo diabetic rats treated with guanethidine. Treatment caused a functional adrenergic sympathectomy, and blood flow increased to within the normal range. Conduction velocity, depressed by 26% with diabetes, was normalized by treatment. These observations support the hypothesis that hyperglycemia-induced blood flow reductions and resultant endoneurial hypoxia are important factors underlying nerve conduction deficits early in the development of diabetic neuropathy.
Therapeutic potential of targeting IL-1 and IL-18 in inflammation (2004)

Interleukin (IL)-1 and IL-18 are cytokines that play a major role in autoimmune and inflammatory human disease. Both cytokines drive a wide range of pro-inflammatory effector networks in many cell types and use common signal transduction cascades. IL-1, IL-18 and other members of the IL-1 superfamily are expressed at elevated levels in tissue and fluid samples isolated from patients with many chronic inflammatory diseases. These cytokines are primary drivers in acute and chronic animal models of inflammation and their blockade has been shown to ameliorate disease in preclinical studies. Biological agents that target IL-1 have demonstrated efficacy in patients with rheumatoid arthritis, and further agents targeting IL-1 or IL-18 neutralisation are in clinical development. The potential for such agents spans human disease where tissue destruction is a primary end point of cytokine action.
Resistant rootstocks may control fanleaf degeneration of grapevines (1989)

Two rootstock selections were found to be highly resistant to feeding by the dagger nematode, carrier of the disease, in large-scale Napa Valley tests and are being recommended for planting in infested vineyards.
High-level IL-12 production by human dendritic cells requires two signals (1998)

IL-12 is a key cytokine in the development of Th1 responses. IL-12 production by antigen-presenting cells (APC) can be induced by the interaction between CD40 on the APC and CD40 ligand (CD40L) expressed on T cells after activation. Our previous study indicated that in dendritic cells (DC), the only APC that can activate naive T(h) cells efficiently, the mere CD40 engagement is insufficient to induce IL-12 production. The aim of the present study was to dissect the conditions for efficient IL-12 production by DC further. Using populations of naive and memory Th cells, recombinant CD40L, neutralizing and blocking antibodies, and by determining IFN-gamma production and CD40L expression levels, we here show that T cell-induced IL-12 production by DC results from the action of two signals, mediated by CD40L and IFN-gamma, and that the inability of naive T(h) cells to induce IL-12 production resides in their inability to produce IFN-(gamma). Other factors than CD40L and IFN-gamma can provide the required signals for IL-12 production by DC, as either factor could be replaced by lipopolysaccharide (LPS). The two-signal requirement proved unique for the production of IL-12, since either CD40 engagement or LPS was sufficient for the efficient production of tumor necrosis factor-alpha, IL-8 and the p40 subunit of IL-12, and may be considered as a safety mechanism for optimal control of potentially harmful T(h)1 responses.