gebhart/patrepeval huggingface dataset:
Quantification of myocardial perfusion with myocardial contrast echocardiography during left atrial injection of contrast. Implications for venous injection. (1994)

Myocardial perfusion can be quantified from time-intensity curves derived from the anterior myocardium after LA injection of contrast. Background-subtracted peak video intensity in this situation correlates closely with MBV. When MBV and MBF are closely coupled, such as during inotropic stimulation of the heart, background-subtracted peak video intensity also correlates closely with MBF. Since there are similarities in the models of LA and venous injections, these data indicate that it may be feasible to quantify myocardial perfusion with myocardial contrast echocardiography after venous injection of contrast.
Fish oil: a potent inhibitor of platelet adhesiveness [see comments] (1990)

The effect of fish oil administration on platelet function was studied in eight normal individuals, four men and four women, who received fish oil equivalent to 6 g eicosapentaenoic acid per day for a period of 25 days. Platelet aggregation, platelet adhesion, phospholipid and fatty acid distribution were measured at periodic intervals before, during, and after the period of fish oil administration. Platelet aggregation induced by arachidonic acid, adenosine diphosphate, and collagen showed a moderate increase in ED 50 in response to the administration of fish oil. Conversely, platelet adhesion to fibrinogen and collagen I, which was studied at low shear rates in a laminar flow chamber, showed a striking 60% to 65% decrease after fish oil supplementation of the diet. The change in adhesiveness could be correlated with the pseudopodia formed in response to agonistic stimulation. Scanning electron microscopic examination of adherent platelets showed an overall reduction of pseudopodia that appeared short and stubby on fish oil administration. The profile of the fatty acids extracted from plasma confirmed compliance of the volunteers with their dietary supplements. Analysis of phospholipids showed changes in sphingomyelin, lysophosphatidylcholine, and phosphatidylcholine between pseudopodia and platelet cell bodies. Fish oil administration did not affect their overall distribution except for a moderate decrease in phosphatidylethanolamine in platelet pseudopodia. Changes were also recognized in the total fatty acids extracted from platelets, affecting primarily arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. There were no changes in platelet adhesiveness in a group of five normal individuals who received a vegetable oil supplement of equal dose and duration as that of the fish oil. We conclude from these studies that fish oil, at least when administered over a limited period of time, is an effective inhibitor of platelet adhesiveness.
Energy Loss Spectroscopy and Electron Microscopy of Photoluminescent p-type Porous Silicon Treated with NaOH and NH3 Solutions (2002)

Porous silicon (PS) formed electrochemically on crystalline silicon at room temperature is known to be visibly photoluminescent Several models have been proposed for the mechanism of photoluminescence. However, little agreement has been attained yet. It is known that the PL is sensitive to both chemical components and microstructures of PS layer. To clarify the effect of microstructure and chemical components of PS on PL is definitely helpful to understand the mechanism of PL of PS. In the present work, electrochemically formed PS on p-type silicon wafers were etched by NaOH and NH 3 hydro-solutions, in order to study the relation between PL and Si-oxide layer on the surface of the PS layer. The change in PL of the treated specimens has been correlated with the changes in local chemical states and microstructure of PS layer with EELS and TEM.
Identification of Lactam–Lactim Tautomers of Aromatic Heterocycles in Aqueous Solution Using 2D IR Spectroscopy (2012)

The tautomerism of aromatic heterocycles is of great interest because it directly affects their chemical properties and biological function. The tautomerism of 2-pyridone, 6-chloro-2-pyridone, and 4-pyrimidinone have been examined in D(2)O using FTIR, two-dimensional IR (2D IR) spectroscopy and density functional theory (DFT) calculations. Using the 2D IR cross-peak patterns, the lactim tautomer of 6-chloro-2-pyridone was separated from the lactam tautomer, and its population was observed to increase with temperature. The equilibrium constant of [lac-tam]/[lactim] was determined to be 2.1 at room temperature for 6-chloro-2-pyridone. Similarly, the N1H and N3H lactam tautomers of 4-pyrimidinone were identified with 2D IR. To assign the vibrational modes of different tautomers, DFT calculations of these chemical species were performed with explicit water molecules, and the hydration effects on the vibrational frequencies and intensities were established.
Adenovirus-Mediated p21 <sup>(WAF1/SDII/CIP1)</sup> Gene Transfer Induces Apoptosis of Human Cervical Cancer Cell Lines (1999)

p21((WAF1/SDII/CIP1)) (p21) arrests cell growth by inhibiting cyclin-depend kinases. To explore the potential of using p21 for the gene therapy of cervical cancer, we infected human papillomavirus (HPV)-positive cervical cancer cells (HeLa, SiHa, and Z172) and HPV-negative cervical cancer cells (C33A) with recombinant adenovirus encoding p21 cDNA. The results revealed that effective inhibition of cell growth could be achieved by sense p21 adenovirus but not antisense p21 adenovirus infection and occurred through apoptosis as measured by DNA fragmentation and chromatin condensation. Apoptosis was also observed in xenografts of human cervical cancer cells infected with sense p21 adenovirus, as confirmed by in situ terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL). The apoptosis was not prevented by overexpression of the bcl-2 transgene. To sum up, the apoptotic effect suggests that p21 should be a tumoricidal agent instead of a tumoristatic agent in preventing cervical cancers. In addition, our report substantiates the combination of the high efficiency of adenovirus vector-mediated gene delivery and the apoptotic effect of p21.
<title>Gamma spectrometer XENON for space gamma burst study on board ISS</title> (1998)

Designs of high pressure xenon gamma-spectrometer with high energy resolution is considered. This device is intended for research of space gamma-radiation and space gamma-bursts. It consists of four independent gamma-detectors which are cylindrical ionization chambers with shielding grids. They are filled with high pressure xenon with density 0.5 g/cm<SUP>3</SUP>. Working volume of each chamber is 6000 cm<SUP>3</SUP>. Energy resolution of the gamma-spectrometer is 2.5% at energy 662 keV and 1.5% at energy 1170 keV. Its sensitive surface equals to 2500 cm<SUP>2</SUP>. It is planned to install the developed instrumentation on the scientific power platform of International Space Station.
Targeting complement system to treat myasthenia gravis (2014)

While the complement system is desired for protective immunity, antibody- and complement-mediated neuromuscular junction (NMJ) destruction, a hallmark of myasthenia gravis (MG) or experimental autoimmune MG (EAMG), is a significant concern. Evidence suggests that the binding of complement factors to the pathogenic anti-acetylcholine receptor (AChR) autoantibody induces the formation of membrane attack complexes (MAC), which ultimately lead to NMJ destruction and muscle weakness. Studies corroborating the evidence show that the complement (C3-C6)-deficient or complement inhibitor (anti-C1q, soluble CR1, anti-C6, and C5 inhibiting peptide)-treated animals are highly resistant to EAMG induction, whereas the deficiency of the naturally occurring complement inhibitors, such as the decay-accelerating factor (DAF), increases EAMG susceptibility. Notably, the complement-inhibited animals do not exhibit significant immunosuppression but only a marginal reduction in the production of certain cytokines and immunoglobulin isotypes. A preliminary clinical trial using antibody-based C5 inhibitor eculizumab has been shown to be of potential use for MG treatment. The inhibition of the classic complement pathway (CCP) alone appears to be enough to suppress EAMG, suggesting that the complement inhibitors targeting specifically the classic pathway could effectively treat MG without causing immunosuppressive and other side effects. For instance, a recent non-antibody-based therapeutic approach selectively targeting the CCP component C2 by small interfering RNA (siRNA) has proven useful in EAMG treatment. The treatment strategies developed for MG might also be beneficial for other complement-mediated autoimmune diseases.
[Testing of monoclonal antibodies to human interferon]. (1986)

A comparative study of testing methods for polyclonal and monoclonal antibodies to human interferon using direct and reverse neutralization of the antiviral activity of interferon as well as ELISA was carried out. The activity of antibodies in ELISA was dozens of times higher than in neutralization tests. Polyclonal antibodies from the sera of mice immunized with alpha 2 interferon had a higher neutralizing capacity. M-5 monoclonal antibodies in specimens of ascitic fluid induced by inoculation of mice with hybrid cells exhibited an increase in both binding and neutralizing activity as compared with specimens of the culture fluid. Immunoglobulins from the ascitic and culture fluid of nonproductive myeloma cells as well as hybridomas producing monoclonal antibodies of other specificities showed practically no reaction with interferon in any of the tests under study. The screening of monoclonal antibodies intended for research and biotechnological purposes requires a composite analysis in both neutralization and binding tests in order to recover purposefully the hybrid clones producing antibodies with both or one of these properties.
De novo assembly of potential linear artificial chromosome constructs capped with expansive telomeric repeats (2011)

We successfully developed a procedure that circumvents the problem of cloning and maintaining long arrays of telomeric DNA sequences that are not stable in E. coli. Our procedure allows development of AC constructs in different eukaryotic species that are capped with long and designed sizes of telomeric DNA fragments.
Retaining Wall Made of PC Piles with Special Cross-Section (1973)

Recently a demand for adopting a noiseless and vibrationless construction method in the field work is growing more and more in Japan.PW-method (or the pile wall construction method) presented in this paper is an unique noiseless and vibrationless construction technique of continuous retaining wall in the field by using precast prestressed concrete piles having special cross-section.Since 1967, when this method was first applied to shore protection works at the Neyagawa River by the Bureau of Construction of Osaka Prefecture, it becomes popular year by year.This paper introduces the outline of “Draft of design code of self-supporting prestressed concrete sheet piles” prepared by the Research Group on “Pre-fabrication of bank-revetment works” in the Society of Materials Science, Japan.Various advantages of PW-method over the retaining wall construction method with temporary horizontal sufforts as well as further improvements needed for PW-method are also discussed. In addition, a convenient method of determining the embedded length of piles is proposed on the basis of the theoretical and experimental results.
Systematic Coarse-Graining of the Dynamics of Self-Attractive Semiflexible Polymers (2014)

We develop a coarse-graining procedure, using bead–rod chains with varying numbers of rods per Kuhn length (Nr,K), to model the conformational dynamics of polymer chains with bending stiffness and self-attraction. We find the conditions under which increased chain resolution leads to converged results for the effect of bending stiffness, attractive interaction strength (ε), and shearing flow on the conformational dynamics. As chain stiffness increases, we find a collapse transition that becomes steeper as attractive strength increases. The collapsed state depends not only on the net dimensionless attractive strength ε* = εNr,K between each Kuhn step of the chain but also on the ratio of bead diameter to Kuhn length (σ*). At high ε* (>0.8/σ*), collapsed globules are produced at moderate chain diameter σ* = 1/4, while for fat chains with σ* = 1, helices are formed, and for thin ones with σ* = 1/16, tori, folded bundles, and finally globules are formed as ε* increases.
Virtual Reality Simulation in Peritoneal Dialysis Training: The Beginning of a New Era (2018)

Previous studies on the effectiveness of learning showed that VR training applications are superior to traditional methods, such as text- or video-based training. However, no study has been undertaken in the context of dialysis. We believe that the implementation of VR training programs in clinical practice will be beneficial in improving the patient's proficiency, and thereby the quality and safety of PD.
A semi‐micro method for the determination of lignin and its use in predicting the digestibility of forage crops (1972)

Abstract The lignin content of dried grasses can be measured, after prior removal of interfering phenolic materials, by dissolving the residue in 25% acetyl bromide in acetic acid and determining the absorption at 280 nm. The absorption values can also be used to predict the nutritive value of dried grasses, hays and silages.
Suppressors of RNA silencing encoded by plant viruses and their role in viral infections (2005)

RNA silencing as a robust host defense mechanism against plant viruses is generally countered by virus-encoded silencing suppressors. This strategy is now increasingly recognized to be used by animal viruses as well. We present here an overview of the common features shared by some of the better studied plant viral silencing suppressors. We then briefly describe the characteristics of the few reported animal viral suppressors, notably their extraordinary ability of cross-kingdom suppression. We next discuss the basis for biased protection of viral RNA and subviral parasites by silencing suppressors, the link between movement and silencing suppression, the influence of temperature on the outcome of viral infection and the effect of viral silencing suppressors on the microRNA pathway.
A Grid-Controlled Color Kinescope (1951)

A new color kinescope makes use of a series of closely spaced screens, each covered with a different primary color phosphor and separated from each other by fine mesh control grids. Small voltage changes of these grids control the depth of penetration of the scanning beam or beams into this assembly of screens. This arrangement permits individual excitation of any one or combination of the primary colors which go to make up the colored image. Experimental tubes have been built, first in two-color form to test principles, and then in three-color form. They have been operated with a color picture using the RCA color television system signal.
Narrating data structures (2008)

Learning computing with respect to the context of its use has been linked in previous reports to student motivation in introductory Computer Science (CS) courses. In this report, we consider the role of context in a second course. We present a case study of a CS2 data structures class that uses a media computation context. In this course, students learn data structures and object-oriented (OO) programming through a pervasive narrative about how real media professionals use data structures to model the real world and to construct the digital images, sounds, and animations with which the students are familiar in their daily lives. We found that context played a different role in a second course than in a first course. We found evidence that some students did not need context to appreciate computing, but we also found evidence that context can help students get engaged with the material that they otherwise do not find interesting. In particular, the narrative aspect of a context may help students in relating the elements of the course and may even help with learning.
High-speed modal decomposition of mode instabilities in high-power fiber lasers (2011)

A high-speed mode analysis technique is required to gain fundamental understanding of mode instabilities in high-power fiber laser systems. In this work a technique, purely based on the intensity profile of the beam, is demonstrated to be ideally suited to analyze fiber laser dynamics. This technique, together with a high-speed camera, has been applied to the study of the temporal dynamics of mode instabilities at high average powers with up to 20,000 frames per second. These measurements confirm that energy transfer between the fluctuating transversal modes takes place in millisecond-time-scale.
Sampling Signals With a Finite Rate of Innovation on the Sphere (2013)

The state of the art in sampling theory now contains several theorems for signals that are non-bandlimited. For signals on the sphere however, most theorems still require the assumptions of bandlimitedness. In this work we show that a particular class of non-bandlimited signals, which have a finite rate of innovation, can be exactly recovered using a finite number of samples. We consider a sampling scheme where K weighted Diracs are convolved with a kernel on the rotation group. We prove that if the sampling kernel has a bandlimit L = 2K then (2K - 1)(4K - 1) + 1 equiangular samples are sufficient for exact reconstruction. If the samples are uniformly distributed on the sphere, we argue that the signal can be accurately reconstructed using 4K <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> samples and validate our claim through numerical simulations. To further reduce the number of samples required, we design an optimal sampling kernel that achieves accurate reconstruction of the signal using only 3K samples, the number of parameters of the weighted Diracs. In addition to weighted Diracs, we show that our results can be extended to sample Diracs integrated along the azimuth. Finally, we consider kernels with antipodal symmetry which are common in applications such as diffusion magnetic resonance imaging.
Narrow linewidth and wavelength tunable multiple quantum well λ/4 shifted distributed feedback laser (1990)

Coherent optical fiber communication systems require a narrow linewidth and wide wavelength tunability. Recently we reported a multielectrode λ / 4 shifted DFB laser with a long cavity exhibiting narrow linewidth, wide wavelength tuning range, and high output power.1 A reduction of the linewidth was also reported in the InGaAs multiple quantum well DFB laser.2 We introduce the MQW structure grown by MO-VPE into this structure and achieve a narrow linewidth of 350 kHz, which is the smallest value in laser diodes without external components.
A Method for Comparing Profiles of Repeated Measurements (1987)

On propose une methode de comparaison des profils de mesures repetees, basee sur la structure de covariance d'ante-dependance de Gabriel (1961-1962). Cette methode est appropriee pour des experiences dans lesquelles aucun point specifique des profils n'est connu pour etre interessant a priori
National survey on outbreaks associated with whirlpool spas. (1984)

A national survey of state epidemiologists sought information on reported outbreaks of illness associated with non-residential whirlpool spas for the period April 1972-July 1, 1982. Reports were received from 49 states. Of the 74 whirlpool-associated outbreaks reported, 72 were characterized as having patients with papular or pustular rash and two were associated with cases of Pontiac fever.
First-Principles Study of Tetragonality Ratio and Unit-Cell Volume Influence on Spontaneous Polarization of BaTiO3 and PbTiO3 (2006)

Using first-principles calculations we have analyzed the dependence of spontaneous polarization on lattice parameters and tetragonality ratio in natural and artificial structures of tetragonal BaTiO3 (BTO) and PbTiO3 (PTO), in order to establish the conditions needed for obtaining increased spontaneous polarization. Conventional knowledge of the polarization in PTO being higher than in BTO due to its larger tetragonality ratio and increased chemical activity of the A-site cation has been confirmed. In addition, a peculiar dependence of the spontaneous polarization on unit cell volume has been revealed. Specifically, at the equal tetragonality ratio, a given ferroelectric material (be it BTO or PTO), with a larger unit cell volume will have a larger spontaneous polarization. This may be related to the augmenting or reduction of short-range repulsion forces that tend to stabilize a centrosymmetrical structure. Therefore, a large tetragonality ratio is not absolutely necessary for obtaining increased spontaneous polarization, if the unit cell volume is large. The present results might partly explain why one should expect that BiFeO3, with a rather modest tetragonality ratio in thin film form, should have very large spontaneous polarization. That is, the chemical bonding and the unit cell volume are similar to PTO, whose polarization is close to 100μC/cm2.
Radiolytic study of α‐tocopherol oxidation in ethanolic solution (1985)

The nature of the final product and the kinetic scheme are discussed.
Identification of an Ordered Compact Structure within the Recombinant Bovine Fibrinogen αC-Domain Fragment by NMR (2006)

The NMR solution structure of the bovine fibrinogen alphaC-domain fragment, including residues Aalpha374-538, reveals a type-I' beta-hairpin, restricted at the base by a C423-C453 disulfide linkage and a short turn preceding C423. Although both faces of the hairpin are formed mainly by hydrophilic residues, one of them is uncharged while the other has a characteristic pattern of charged residues which are highly conserved among vertebrate species. Chemical shift indexing and relaxation data indicate the presence of a collapsed hydrophobic region next to the hairpin that includes approximately 30 residues with slower concerted motion and higher content of nonpolar residues and, according to a previous study (Tsurupa, G., Tsonev, L., and Medved, L. (2002) Biochemistry 41, 6449-6459), may cooperate with the hairpin to form a compact cooperative unit (domain). Structure and relaxation data show that the region between C423 and C453 is populated by both random coil and beta-structure, suggesting that the cooperative structure in the isolated alphaC-domain is intrinsically unstable. This observation is in agreement with a very low energy of stabilization of the Aalpha374-538 fragment determined in unfolding experiments. The low stability of the alphaC-domain suggests a possible explanation for the previously observed intra- and intermolecular interactions of these domains in fibrinogen and fibrin.