gebhart/patrepeval huggingface dataset:
DEHYDRATION OR BECKMANN REARRANGEMENT OF ALDOXIMES WITH BORON FLUORIDE. CONVERSION OF ALDOXIMES TO CORRESPONDING AMIDES<sup>1</sup> (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDEHYDRATION OR BECKMANN REARRANGEMENT OF ALDOXIMES WITH BORON FLUORIDE. CONVERSION OF ALDOXIMES TO CORRESPONDING AMIDES1DAVID S. HOFFENBERG and CHARLES R. HAUSERCite this: J. Org. Chem. 1955, 20, 11, 1496–1500Publication Date (Print):November 1, 1955Publication History Published online1 May 2002Published inissue 1 November 1955https://pubs.acs.org/doi/10.1021/jo01128a006https://doi.org/10.1021/jo01128a006research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
OpenFlow control for cooperating AQM scheme (2010)

OpenFlow is defined as a unified control plane and architecture for packet and circuit switched networks. We deal with the congestion control problem in the multi-layer network, and propose a cooperative congestion control scheme for a domain with multiple AQM routers based on the OpenFlow architecture. This scheme operates three different cases in the domain, where the domain server share information with core router and edge router interactively. Moreover, we use the OpenFlow to control atomic behaviors for packet handing within each switching element, which could manipulate such behaviors from a control server, thus users can program their own network behaviors by injecting their own control programs into the server. The congestion control algorithm is simulated to ensure the convergence of the average rate and throughout capacity to its equilibrium state when there are many high-rate flows in multilayer network. Finally, we compared its performance of the dropping probability and the queue length queue length with respect to the single router control results.
Behavioral-level fault simulation (1988)

An approach to fault simulation is presented in which behavioral fault models represent complex failures in VLSI designs. Errors are deliberately introduced into the description of a design that contains no faults. These errors can be fault values of variables that represent state or timing parameters, a faulty description that is substituted for part of the good description, or a combination of these. The algorithm guarantees accurate results by deferring the output assignments. The approach can also be used to detect and discard inconsistent output assignments. The algorithm has been implemented in Stanford University's Sable simulator using the Adlib behavioral modeling language.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An event-driven multi-threading architecture for embedded systems (1997)

In this paper we present an event driven multi-threading architecture and its underlying event flow system model of computation as a framework for the implementation of complex reactive and communication systems. Existing process oriented specification languages can be used to specify the system and embedded in the model. The target architecture covers a wide variety of architectures, varying from small FSMs to large processors, which are interconnected by a network template which performs dynamic scheduling and communication for different levels of process granularity and timing. Interconnect and module implementation and optimisation is based on an event flow graph model (EFG). In this paper we present our system model and the architectural template and show how they can be applied to an industrial application example.
297. The firmness of rennet curd; its measurement and variations (1942)

A method is described for the measurement of the firmness of the rennet curd from 100 ml. samples of milk coagulated under conditions simulating those of the cheesemaking process. Tests with a series of homogeneous curds ranging in firmness from very soft to very hard showed that the curds behaved as elastic gels of varying modulus, and the deformation produced under a suitable compressive load was accordingly adopted as a simple objective measure of firmness. The method was used to observe the variation in the curd firmness of samples of milk from individual cows and separate quarters, with some observations on the relationship between curd firmness and milk composition, and the effect on curd firmness of variations in the following factors: acidity, addition of calcium chloride, amount of rennet, time of coagulation, and the admixture of soft-curd milk. The results of these experiments indicate that the method provides a satisfactory measure of the rennet curd firmness of small samples of milk. The utility and applications of the method are discussed, and the suggestion is made that a standardized reproducible test on the same principle should be evolved to serve the same function with regard to milk for cheese making as the standardized measurement of curd tension serves with regard to the digestibility and suitability of milk for infant feeding.
Fundamentals of OOP and Data Structures in Java (2000)

Fundamentals of OOP and Data Structures in Java is a text for an introductory course on classical data structures. Part One of the book presents the basic principles of Object-Oriented Programming (OOP) and Graphical User Interface (GUI) programming with Java as the example language. Part Two introduces each of the major data structures with supporting, GUI-based laboratory programs designed to reinforce the basic concepts and principles of the text. These laboratories allow the reader to explore and experiment with the properties of each data structure. All source code for the laboratories is available on the web. By integrating the principles of OOP and GUI programming, this book takes the unique path of presenting the fundamental issues of data structures within the context of paradigms that are essential to today's professional software developer. The authors assume the reader has only an elementary understanding of Java and no experience with OOP.
Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases. (2001)

We recently reported that acidic (aFGF) and basic (bFGF) fibroblast growth factors confer a broad spectrum chemoresistance in solid tumors, and that suramin, an inhibitor of multiple growth factors including aFGF and bFGF, enhanced the in vitro antitumor activity of several anticancer drugs including paclitaxel (Song, S., et al., Proc. Natl. Acad. Sci. USA, 97: 8658-8663, 2000). The present study investigated in vitro and in vivo interaction between paclitaxel and suramin, using human PC3-LN cells which, upon i.v. injection into immunodeficient mice, yielded lung metastases in 100% of animals. In in vitro studies, conditioned medium (CM) obtained from histocultures of rat lung metastases induced a 3-fold resistance. The addition of suramin had no effect in the absence of CM but reversed the CM-induced resistance; calculations based on the IC(50) values indicate a complete reversal in the presence of <20 microM suramin. Analysis by the combination index method indicates a synergistic interaction between paclitaxel and suramin. In in vivo studies, animals with well-established lung metastases (at least five nodules of 1 mm in diameter) were treated i.v. with paclitaxel (15 mg/kg) and suramin (10 mg/kg) administered twice weekly for 3 weeks. Single-drug therapy with paclitaxel or suramin did not reduce body weight. Suramin alone had no antitumor activity. Paclitaxel alone reduced the tumor size by approximately 75%, reduced the density of nonapoptotic cells by approximately 70% in residual tumors, and enhanced the fraction of apoptotic cells by approximately 3-fold. The addition of suramin to paclitaxel therapy enhanced the antitumor effect, resulting in an additional 5-fold reduction of tumor size, an additional 9-fold reduction of the density of nonapoptotic cells, and an additional 30% increase in the apoptotic cell fraction. These data indicate significant enhancement of the efficacy of paclitaxel by suramin and support the use of nontoxic doses of suramin with paclitaxel in the treatment of lung cancer.
A review of the methods available for the detection and determination of small amounts of cyanide (1963)

The first page of this article is displayed as the abstract.
Botulinum Toxin Injection in Achalasia Before Myotomy (1998)

1 Veterans Affairs Medical Center and Wright State University School of Medicine Dayton, OH * School of Medicine, Division of Gastroenterology, VA Medical Center, 4100 West Third Street (111), Dayton, OH 45428-1008 Received December 01, 1997; accepted February 11, 1998.
Metallocyclodextrins as Building Blocks in Noncovalent Assemblies of Photoactive Units for the Study of Photoinduced Intercomponent Processes (2001)

Cyclodextrin cups have been employed to build supramolecular systems consisting of metal and organic photoactive/redox-active components; the photoinduced communication between redox-active units assembled in water via noncovalent interactions is established. The functionalization of a beta-cyclodextrin with a terpyridine unit, ttp-beta-CD, is achieved by protection of all but one of the hydroxyl groups by methylation and attachment of the ttp unit on the free primary hydroxyl group. The metalloreceptors [(beta-CD-ttp)Ru(ttp)][PF(6)](2), [(beta-CD-ttp)Ru(tpy)][PF(6)](2), and [Ru(beta-CD-ttp)(2)][PF(6)](2) are synthesized and fully characterized. The [(beta-CD-ttp)Ru(ttp)][PF(6)](2) metalloreceptor exhibits luminescence in water, centered at 640 nm, from the (3)MLCT state with a lifetime of 1.9 ns and a quantum yield of Phi = 4.1 x 10(-)(5). Addition of redox-active quinone guests AQS, AQC, and BQ to an aqueous solution of [(beta-CD-ttp)Ru(ttp)](2+) results in quenching of the luminescence up to 40%, 20%, and 25%, respectively. Measurement of the binding strength indicates that, in saturation conditions, 85% for AQS and 77% for AQC are bound. The luminescence quenching is attributed to an intercomponent electron transfer from the appended ruthenium center to the quinone guest inside the cavity. Control experiments demonstrate no bimolecular quenching at these conditions. A photoactive osmium metalloguest, [Os(biptpy)(tpy)][PF(6)], is designed with a biphenyl hydrophobic tail for insertion in the cyclodextrin cavity. The complex is luminescent at room temperature with an emission band maximum at 730 nm and a lifetime of 116 ns. The osmium(III) species are formed for the study of photoinduced electron transfer upon their assembly with the ruthenium cyclodextrin, [(beta-CD-ttp)Ru(ttp)](2+). Time-resolved spectroscopy studies show a short component of 10 ps, attributed to electron transfer from Ru(II) to Os(III) giving an electron transfer rate 9.5 x 10(9) s(-)(1).
ELECTRON BEAM PROCESSING AND POLYMERIC MATERIALS: TECHNOLOGICAL ASPECTS AND CHEMICAL MODIFICATIONS (1995)

Article ELECTRON BEAM PROCESSING AND POLYMERIC MATERIALS: TECHNOLOGICAL ASPECTS AND CHEMICAL MODIFICATIONS was published on August 1, 1995 in the journal Journal of Polymer Engineering (volume 15, issue 1-2).
I.—<i>A synoptic classification of the false scorpions or chela-spinners, with a report on a Cosmopolitan collection of the same</i>.—Part II. <i>The Diplosphyronida (Arachnida-Chelonethida)</i> (1930)

(1930). I.—A synoptic classification of the false scorpions or chela-spinners, with a report on a Cosmopolitan collection of the same.—Part II. The Diplosphyronida (Arachnida-Chelonethida). Annals and Magazine of Natural History: Vol. 5, No. 25, pp. 1-48.
Breakdown of the Blood–Brain Barrier after Fluid Percussive Brain Injury in the Rat. Part 1: Distribution and Time Course of Protein Extravasation (1992)

Experimental brain injury is associated with marked vasogenic edema, as evidenced by an increase in brain water content. This prominent and widespread response raises questions about the vulnerability of microvasculature in the brain to injury. In the present report we further characterize the vascular response by evaluating the integrity of the blood-brain barrier to circulating proteins. Vascular permeability to endogenous immunoglobulins (IgG) and to the protein horseradish peroxidase (HRP) was examined after a lateral, fluid percussive brain injury in the rat. In study 1 IgG was immunolocalized in brain sections 1-24 hr after injury. In studies 2 and 3 HRP was given intravenously either before impact (study 2) or 10 min before sacrifice (study 3). Permeability to this protein was assessed at 1-6 hr (study 2) or at 1-72 hr (study 3) after injury. In studies 1 and 2 the extravascular accumulation of proteins was evaluated. Pronounced abnormal permeability to IgG and HRP occurred within the first hour after injury and was widespread throughout both hemispheres. The intensity of immunostaining for IgG increased with time up to 24 hr after injury. In contrast, maximal extravascular accumulation of HRP occurred within the first hour after injury. In study 3 the time course for re-establishment of the blood-brain barrier to HRP was determined. Maximal permeability occurred at 1 hr after injury. At 24 hr abnormal permeability was restricted to the impact site and this area remained permeable up to 72 hr after injury. In summary this study demonstrates that breakdown of the blood-brain barrier to plasma proteins is a prominent feature of experimental brain injury. This abnormal permeability is characterized by its transient expression and widespread distribution. The time course for re-establishment of the blood-brain barrier to circulating proteins is most delayed at the impact site.
Biosynthesis of Inositol in Yeast (1989)

A biochemical, molecular, and genetic analysis of the Saccharomyces cerevisiae INO1 gene and its product, L-myo-inositol-1-phosphate synthase (EC 5.5.1.4) has been carried out. The sequence of the entire INO1 gene and surrounding regions has been determined. Computer analysis of the DNA sequence revealed four potential peptides. The largest open reading frame of 553 amino acids predicted a peptide with a molecular weight of 62,842. The amino acid composition and amino terminus of purified L-myo-inositol-1-phosphate synthase were chemically determined and compared to the amino acid composition and amino terminus of the protein predicted from the DNA sequence of the large open reading frame. This analysis established that the large open reading frame encodes L-myo-inositol-1-phosphate synthase. The largest of several small open reading frames adjacent to INO1 predicted a protein of 133 amino acids with a molecular weight of 15,182 and features which suggested that the encoded protein may be membrane-associated. A gene disruption was constructed at INO1 by eliminating a portion of the coding sequence and replacing it with another sequence. Strains carrying the gene disruption failed to express any protein cross-reactive to antibody directed against L-myo-inositol-1-phosphate synthase. Although auxotrophic for inositol, strains carrying the gene disruption were completely viable when supplemented with inositol. In a similar fashion, a gene disruption was constructed in the chromosomal locus of the 133-amino acid open reading frame. This mutation did not affect viability but did cause inositol to be excreted from the cell.
Alcohol Dehydrogenase of Class IV (σσ‐ADH) from Human Stomach (1994)

Human stomach mucosa contains a characteristic alcohol dehydrogenase (ADH) enzyme, sigma sigma-ADH. Its cDNA has been cloned from a human stomach library and sequenced. The deduced amino acid sequence shows 59-70% identities with the other human ADH classes, demonstrating that the stomach enzyme represents a distinct structure, constituting class IV, coded by a separate gene, ADH7. The amino acid identity with the rat stomach class IV ADH is 88%, which is intermediate between constant and variable dehydrogenases. This value reflects higher conservation than for the classical liver enzymes of class I, compatible with a separate functional significance of the class IV enzyme. Its enzymic features can be correlated with its structural characteristics. The residues lining the substrate-binding cleft are bulky and hydrophobic, similar to those of the class I enzyme; this explains the similar specificity of both classes, compatible with the origin of class IV from class I. Position 47 has Arg, in contrast to Gly in the rat class IV enzyme, but this Arg is still associated with an extremely high activity (kcat = 1510 min-1) and weak coenzyme binding (KiaNAD+ = 1.6 mM). Thus, the strong interaction with coenzyme imposed by Arg47 in class I is probably compensated for in class IV by changes that may negatively affect coenzyme binding: Glu230, His271, Asn260, Asn261, Asn363. The still higher activity and weaker coenzyme binding of rat class IV (kcat = 2600 min-1, KiaNAD = 4 mM) can be correlated to the exchanges to Gly47, Gln230 and Tyr363. An important change at position 294, with Val in human and Ala in rat class IV, is probably responsible for the dramatic difference in Km values for ethanol between human (37 mM) and rat (2.4 M) class IV enzymes.
Multicentre prospective study on dengue classification in four South‐east Asian and three Latin American countries (2011)

Based on these results, a revised classification system comprised of two entities, 'Dengue' and 'Severe Dengue', was proposed and has now been incorporated into the new WHO guidelines.
Effect of probiotic Bifidobacterium longum BB536 [corrected] in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial. (2006)

Probiotic microorganisms have been shown to be effective in the treatment of allergic inflammation and food allergy, but their efficacy remains controversial. This study tested the effect of a yogurt supplemented with a probiotic strain Bifidobacterium longum BB536 in the treatment of Japanese cedar pollinosis (JCPsis). Forty subjects with a clinical history of JCPsis were given yoghurt either containing BB536 (BB536 yoghurt) or without BB536 (placebo yoghurt) at 2 X 100 g per day for 14 weeks, in a randomized, double-blind, placebo-controlled trial. Subjective symptoms and self-care measures were recorded daily and blood samples were taken before and during the intervention (at weeks 4, 9, and 14) to measure the blood parameter levels related to JCPsis. Yoghurt supplemented with BB536 significantly alleviated eye symptoms compared with placebo yoghurt (odds ratio 0.31; 95% confidence interval 0.10-0.97; p = 0.044). Although no statistically significant differences were detected, nasal symptoms such as itching, rhinorrhea, and blockage, as well as throat symptoms tended to be relieved with the BB536 yoghurt. BB536 tended to suppress the decreasing blood levels of interferon-gamma (IFN-y) and the increasing blood eosinophil rates; a significantly higher IFN-gamma level was observed for the difference from baseline at week 4. A decreased trend in the difference from baseline levels of JCP-specific IgE levels was also observed at week 4 in the BB536 group compared with the placebo group. In conclusion, these results suggest that intake of BB536-supplemented yoghurt may relieve JCPsis symptoms, probably through a modulating effect on Th balance.
COVID–19-associated coagulopathy: An exploration of mechanisms (2020)

An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to the virus SARS-CoV-2, has infected millions of people and remains a threat to many more. Most critically ill patients have respiratory failure and there is an international effort to understand mechanisms and predictors of disease severity. Coagulopathy, characterized by elevations in D-dimer and fibrin(ogen) degradation products (FDPs), is associated with critical illness and mortality in patients with COVID-19. Furthermore, increasing reports of microvascular and macrovascular thrombi suggest that hemostatic imbalances may contribute to the pathophysiology of SARS-CoV-2 infection. We review the laboratory and clinical findings of patients with COVID-19-associated coagulopathy, and prior studies of hemostasis in other viral infections and acute respiratory distress syndrome. We hypothesize that an imbalance between coagulation and inflammation may result in a hypercoagulable state. Although thrombosis initiated by the innate immune system is hypothesized to limit SARS-CoV-2 dissemination, aberrant activation of this system can cause endothelial injury resulting in loss of thromboprotective mechanisms, excess thrombin generation, and dysregulation of fibrinolysis and thrombosis. The role various components including neutrophils, neutrophil extracellular traps, activated platelets, microparticles, clotting factors, inflammatory cytokines, and complement play in this process remains an area of active investigation and ongoing clinical trials target these different pathways in COVID-19.
Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas. (2005)

The subcellular localization of ERBIN in normal human skin is similar to that of Erb-B2 and varies with cell differentiation. Based on our findings and on the biological activities of Erb-B2, it is conceivable that disturbed expression or functioning of ERBIN and Erb-B2 is implicated in the development of the malignant phenotype of BCC.
Salt and hypertension. Lessons from animal models that relate to human hypertension. (1991)

A high NaCl diet can raise blood pressure in both susceptible people and in susceptible animals, and the mechanisms are probably quite similar for both humans and animals. The possibly harmful effects of a high NaCl diet are not unexpected since both prehistoric man and mammals evolved in a low NaCl world. Evolutionary forces molded mammals to adapt well to a low sodium intake; the modern high NaCl intake goes "against the grain" of this adaptation. The high NaCl diet can cause premature mortality by raising blood pressure in susceptible people. We have new evidence that in a hypertensive setting, a high NaCl diet can increase mortality even though it does not cause a further rise of blood pressure. Multiple small cerebral infarcts are a partial cause of this excess mortality. Recent evidence also indicates that a high potassium diet reduces the rise of blood pressure caused by a high NaCl diet, whereas a low normal potassium intake encourages an NaCl-induced rise of blood pressure. It is the combination of kidneys that tends to retain NaCl together with a high NaCl intake that produces a rise in blood pressure. This combination tends to cause NaCl retention, which can trigger a rise in blood pressure in susceptible humans and animals. Such a rise in blood pressure can augment renal NaCl excretion and regain the previous NaCl balance. In the Dahl salt-sensitive (DS) rat, there are several renal abnormalities that would tend to encourage sodium retention. By analogy, renal "abnormalities" are probably present in people susceptible to hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)