gebhart/patrepeval huggingface dataset:
Professional homogeneity: Global versus local effects (2016)

Theoretical approaches in studies on professionals are implicitly based on an assumption of homogeneity of attitudes among professionals. However, this assumption has never been validated. This paper examines whether professionals worldwide have relatively homogenous attitudes towards work as compared to non-professionals, and compares two competing theoretical arguments regarding the role of the state in shaping professionals ’ work-related attitudes. These were tested using a multi-national representative sample of 12,015 respondents from twenty-one countries. Multilevel models showed that professionals do display more homogenous attitudes than non-professionals and that the effect of professional group membership on attitudes does not vary across countries.
Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid (2014)

In order to enhance the in vivo codelivery efficiency of gambogic acid (GA) and all-trans retinoic acid (ATRA), our strategy was to entrap GA in the self-assembled nanoparticles based on amphiphilic hyaluronic acid (HA)-ATRA (HRA) conjugate. In this way, GA and ATRA were loaded simultaneously in a nanocarrier and codelivered into the tumor cell through HA receptor-mediated endocytosis. GA-loaded HRA nanoparticles (GA-HRA) were prepared by a dialysis method, and their physicochemical characteristics were investigated as well. GA-HRA exhibited a high drug loading capacity (31.1%), had a particle size in the range of 100-150 nm, and good biocompatibility. HRA nanoparticles were effectively internalized by MCF-7 cells and translocated into the nucleus in a time-dependent manner. The in vivo imaging analysis demonstrated that the fluorescent signals in the tumor were markedly increased with DiR-loaded nanoparticles after intravenous administration compared to free DiR solution, suggesting it has excellent tumor targeting properties. More importantly, GA-HRA exhibited excellent in vivo efficacy with dramatically reduced toxicity. In conclusion, with the assistance of HRA nanoparticles, GA and ATRA can successfully realize an effective combination chemotherapy as well as tumor-targeted delivery.
THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS (1997)

Mutant ras oncogenes and alterations in the mitogenic signaling pathways that they regulate are associated with a wide variety of solid tumors and leukemias for which existing chemotherapeutics have limited utility. Of the possible approaches to inhibit Ras function, much attention has focused on a posttranslational modification, farnesylation, which is required for the subcellular localization of Ras to the plasma membrane and is critical to Ras cell-transforming activity. Inhibitors of the enzyme that catalyzes Ras farnesylation, farnesyl-protein transferase (FPTase), have been developed. These compounds inhibit the tumorigenic phenotypes of ras-transformed cells and human tumor cells in cell culture and in animal models. Moreover, FPTase inhibitors have not demonstrated toxicity to normal cells in culture or to normal tissues in mice. FPTase inhibitors are among the first small molecule compounds designed from studies of oncogenes that might serve as novel cancer chemotherapeutics.
Randomized Controlled Trial of Interventions Designed to Reduce the Risk of Progression to First-Episode Psychosis in a Clinical Sample With Subthreshold Symptoms (2002)

More specific pharmacotherapy and psychotherapy reduces the risk of early transition to psychosis in young people at ultra-high risk, although their relative contributions could not be determined. This represents at least delay in onset (prevalence reduction), and possibly some reduction in incidence.
Service level agreements (1996)

Changes in the management of nurse education have created the need for new guidelines. Jane Early describes how a college of nursing and midwifery set up service agreements
Experimental analysis of the use of angle of arrival at an adaptive antenna array for location estimation (2002)

This paper presents results of an adaptive antenna measurement platform for DCS1800 frequency division duplex operation. A description of the measurement site in central London, UK is followed by a brief note on the data available and used for post-processing in this paper. Frequency division duplex operation is analysed in terms of the estimated peak-energy spectral energy density 'look-direction' in the uplink and downlink channels and compared to GPS estimated positions of a mobile transmitter. Singular point measurements from two specific locations in central London are analysed in terms of delay, Doppler and angular spread. It has been found that the speed of the mobile to duration of the measurement period ratio determine not only the fading statistics but the correlation in the uplink and downlink AOA estimates. Statistical analysis of the angular accuracy of the uplink direction estimate to the GPS estimated angular estimate shows a standard deviation of 35 degrees. It is possible to conclude that DOA based location estimators in a highly scattered environment and using four antenna element panels will be inaccurate to such an extent that DOA based location estimation is probably not viable for E911 requirements in an European context. This location estimate at the 67% percentile is within an angle error, with respect to the 'true' GPS estimated angle of arrival, of /spl plusmn/12 degrees for high mobile speed/measurement period duration ratios and /spl plusmn/30 degrees for all mobile speeds.
Isolation of a full-length complementary DNA coding for human E1 alpha subunit of the pyruvate dehydrogenase complex. (1988)

A 1.5-kilobase cDNA clone for human pyruvate dehydrogenase E1 was isolated from a lambda gt11 expression library by screening with polyclonal antiserum to the E1 alpha subunit of the porcine pyruvate dehydrogenase complex, a polyclonal antibody against bovine pyruvate dehydrogenase complex and a synthetic oligonucleotide based on the known amino acid sequence of the amino-terminal of the bovine pyruvate dehydrogenase-E1 alpha subunit. Nucleotide sequence analysis of the cDNA revealed a 5'-untranslated sequence of 72 nucleotides, a translated sequence of 1170 nucleotides, and a 3'-untranslated sequence of 223 nucleotides with a poly(A) tail. The cDNA structure predicts a leader sequence of 29 amino acids and a mature protein of 362 amino acids comprising an amino-terminal peptide identical to that of the bovine E1 alpha subunit and three serine phosphorylation sites whose sequence was also identical to those in the bovine E1 alpha subunit. The translated sequence for the mature protein differs substantially from that described by Dahl et al. (Dahl, H. H., Hunt, S. M., Hutchison, W. M., and Brown, G. K. (1987) J. Biol. Chem. 262, 7398-7403) by virtue of a frameslip between bases 390 and 594. This amended sequence is confirmed by the presence of additional restriction sites for the enzymes NaeI and HaeII at the beginning and end, respectively, of this section. The leader sequence is typical for mitochondrial enzymes being composed of a combination of neutral and basic residues. The amino acid composition is strikingly similar to that of the bovine protein. This cDNA clone hybridizes with a 1.8-kilobase mRNA on a Northern blot analysis of human fibroblasts, and a second minor band of 4.4 kilobases is also detected.
Hand washing frequency in an emergency department. (1994)

Objectives Previous studies, conducted mainly in ICUs, have shown low compliance with hand-washing recommendations, with failure rates approaching 60%. Hand washing in the emergency department has not been studied. We examined the frequency and duration of hand washing in one emergency department and the effects of three variables: level of training, type of patient contact (clean, dirty, or gloved), and years of staff clinical experience. Design Observational. Setting ED of a 1100-bed tertiary referral, central city, private teaching hospital. Participants Emergency nurses, faculty, and resident physicians. Participants were informed that their activities were being monitored but were unaware of the exact nature of the study. Interventions An observer recorded the number of patient contacts and activities for each participant during 3-hour observation periods. Activities were categorized as either clean or dirty according to a scale devised by Fulkerson. The use of gloves was noted and hand-washing technique and duration were recorded. A hand-washing break in technique was defined as failure to wash hands after a patient contact and before proceeding to another patient or activity. Results Eleven faculty, 11 resident physicians, and 13 emergency nurses were observed. Of 409 total contacts, 272 were clean, 46 were dirty, and 91 were gloved. Hand washing occurred after 32.3% of total contacts (SD, 2.31%). Nurses washed after 58.2% of 146 contacts (SD, 4.1%), residents after 18.6% of 129 contacts (SD, 3.4%), and faculty after 17.2% of 134 contacts (SD, 3.3%). Nurses had a significantly higher hand washing frequency than either faculty (p < 0.0001) or resident physicians (p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
Reviews of Books (1977)

Reviews of Books Get access The English Catholic Community, 1570–1850. By JOHN BOSSY (London: Darton Longman and Todd, 1975. £12). JOHN MILLER JOHN MILLER Queen Mary CollegeLondon Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume XCII, Issue CCCLXII, January 1977, Pages 134–137, https://doi.org/10.1093/ehr/XCII.CCCLXII.134 Published: 01 January 1977
Influence of zinc oxide during different stages of sulfur vulcanization. Elucidated by model compound studies (2005)

Abstract The addition of zinc oxide (ZnO) as an activator for the sulfur vulcanization of rubbers enhances the vulcanization efficiency and vulcanizate properties and reduces the vulcanization time. The first part of this article deals with the reduction and optimization of the amount of ZnO. Two different rubbers, solution‐styrene‐butadiene rubber and ethylene–propylene–diene rubber, have been selected for this study. The results demonstrate that the curing and physical properties can be retained when the level of ZnO (Red Seal) is reduced to 1 or 2 phr, respectively. Of particular interest is nano‐ZnO, characterized by a nanoscale particle distribution. The cure characteristics indicate that with nano‐ZnO, a reduction of zinc by a factor of 10 can be obtained. In the second part, model compound vulcanization is introduced to investigate the effects of ZnO during the different stages of vulcanization. Experiments are described with two models, squalene and 2,3‐dimethyl‐2‐butene, both with benzothiazolesulfenamide‐accelerated vulcanization systems. The results demonstrate the influence of ZnO during the different stages of the vulcanization. With ZnO present, a marked decrease can be observed in the sulfur concentration during an early stage of vulcanization, along with a slight delay in the disappearance of the crosslink precursor. The crosslinked product distribution is influenced as well. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 95: 1388–1404, 2005
Triazolopyrimidine (Trapidil), a Platelet-Derived Growth Factor Antagonist, Inhibits Parathyroid Bone Disease in an Animal Model for Chronic Hyperparathyroidism (2003)

Parathyroid bone disease in humans is caused by chronic hyperparathyroidism (HPT). Continuous infusion of PTH into rats results in histological changes similar to parathyroid bone disease, including increased bone formation, focal bone resorption, and severe peritrabecular fibrosis, whereas pulsatile PTH increases bone formation without skeletal abnormalities. Using a cDNA microarray with over 5000 genes, we identified an association between increased platelet-derived growth factor-A (PDGF-A) signaling and PTH-induced bone disease in rats. Verification of PDGF-A overexpression was accomplished with a ribonuclease protection assay. Using immunohistochemistry, PDGF-A peptide was localized to mast cells in PTH-treated rats. We also report a novel strategy for prevention of parathyroid bone disease using triazolopyrimidine (trapidil). Trapidil, an inhibitor of PDGF signaling, did not have any effect on indexes of bone turnover in normal rats. However, dramatic reductions in marrow fibrosis and bone resorption, but not bone formation, were observed in PTH-treated rats given trapidil. Also, trapidil antagonized the PTH-induced increases in mRNA levels for PDGF-A. These results suggest that PDGF signaling is important for the detrimental skeletal effects of HPT, and drugs that target the cytokine or its receptor might be useful in reducing or preventing parathyroid bone disease.
K. Svoboda: L'Ésthetique d'Aristote (Aristotelova Estetika). Pp. 212. Brno, 1927. (‘ Les Belles Lettres,’ Paris.) 20 fr. (1927)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Reactive extrusion of polypropylene I: Controlled degradation (1988)

Abstract Polypropylene was degraded by injection of a free‐radical initiator during extrusion. Molecular weight distribution, molecular weight averages, and melt flow index were measured to see the effect of initiator concentration (0.00 to 0.04 wt%), temperature (200 and 220°C), and screw rpm (31 and 44). Initiator concentration was the most significant variable. In all cases, increased initiator concentration degraded the high molecular weight tail of the polypropylene and narrowed the molecular weight distribution. Melt flow index varied linearly with initiator concentration beyond 0.01 wt% initiator. Reaction temperature had no effect on the measured properties of the extrudate. This was attributed to the minimum residence time in the extruder being sufficient for all degradation reactions to be completed. It also implied that the same reactions occurred at both temperatures. Increased screw rpm slightly increased molecular weight. No interaction among initiator concentration, temperature, and screw rpm was observed.
Polyguaiacol: a Useful Model Polymer for Lignin Biodegradation Research (1981)

A polymer of ring-labeled [C]o-methoxyphenol ([C]guaiacol) was prepared by peroxidase-H(2)O(2)-catalyzed oxidation of the C-labeled monomeric compound. The ring-labeled [C]polyguaiacol contained 67.71% carbon, 5.09% hydrogen, 27.49% oxygen, 25.44% methoxyl, and 8.60% phenolic hydroxyl. The polymer had an average molecular weight of between 5,000 and 15,000, as determined by gel chromatography. A schematic representation of the polymer, similar to previously published structures of polyguaiacols, was devised to meet these and other analytical parameters. The polymer is primarily composed of o-o and p-p-linked guaiacol moieties, with an occasional o-p-biphenyl link and some p-diphenoquinone structures. An approximate molecular formula is [C(49)O(14)H(31)](n), where n =/> 5.8. Its C(6) formula is C(6)H(2.3)O(0.3) (OH)(0.7)(OCH(3))(1.0). Polyguaiacol has many of the characteristics of a synthetic lignin. It is easier and less expensive to prepare than standard synthetic lignins (dehydrogenation polymers of coniferyl alcohol). It is degraded ([C]polyguaiacol --> CO(2)) by the lignolytic system of the white-rot fungus Phanaerochaete chrysosporium. It is suggested that [C]polyguaiacol may be of value as a substrate for lignin biodegradation research.
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects (2002)

1) IGF-I is less effective than insulin in suppressing EGP and FFA turnover; 2) insulin-resistant type 2 diabetic subjects also exhibit IGF-I resistance in skeletal muscle. However, suppression of EGP by IGF-I is not impaired in diabetic individuals, indicating normal hepatic sensitivity to IGF-I.
Polarization-resolved four-wave mixing microscopy for structural imaging in thick tissues (2012)

We present a polarimetric analysis of the four-wave mixing (FWM) signal emitted by thick tissues, in order to extract structural information on molecular order and orientation. A careful analysis of the polarization distortions introduced by the birefringence of the sample is conducted for the proper interpretation of the results. FWM, compared to other well-known nonlinear optical methods such as second-harmonic generation, gives access to additional information on the symmetry of the molecular distribution. Furthermore, it brings the advantage of being generated in any kind of sample, even when centrosymmetry is present. The model developed here is applied to thick rat-tail tendon samples, composed essentially of collagen fibers. We show that, once the birefringence of the sample is completely characterized, it is possible to retrieve the even-order components of the molecular orientational distribution up to the fourth order of symmetry.
Integrated Voltage, Var Control and demand response in distribution systems (2009)

This paper addresses the requirements for utilizing voltage and Var control for demand response, in an operating environment which includes smart-grid, distribution management systems, advanced metering infrastructure, demand response, and distributed energy resources.
The Rotation of Eigenvectors by a Perturbation. III (1970)

When a Hermitian linear operator is slightly perturbed, by how much can its invariant subspaces change? Given some approximations to a cluster of neighboring eigenvalues and to the corresponding eigenvectors of a real symmetric matrix, and given an estimate for the gap that separates the cluster from all other eigenvalues, how much can the subspace spanned by the eigenvectors differ from the subspace spanned by our approximations? These questions are closely related; both are investigated here. The difference between the two subspaces is characterized in terms of certain angles through which one subspace must be rotated in order most directly to reach the other. These angles unify the treatment of natural geometric, operator-theoretic and error-analytic questions concerning those subspaces. Sharp bounds upon trigonometric functions of these angles are obtained from the gap and from bounds upon either the perturbation (1st question) or a computable residual (2nd question). An example is included.
Hormonal responses to the new potent GnRH antagonist Cetrorelix (1993)

GnRH antagonists, unlike the GnRH agonists, immediately suppress gonadotropins and testosterone secretion without initial stimulatory effect. We report here on a single-dose study with the new GnRH antagonist Cetrorelix (Ac-D-Nal(2)1, D-Phe(4C1)2, D-Pal3, D-Cit6, D-Alal0) in 25 normal men. The study involved five different dose groups (0.25, 0.5, 1.0, 1.5 or 3.0 mg) and subjects were observed over a 40 h period. Five men served as controls. Serum levels of LH, FSH and testosterone decreased rapidly with a dose-related decline for testosterone of 25%, 24%, 41%, 53% and 72%, respectively, for testosterone within the first 8 h of antagonist administration. All effects were reversible and no serious side effects were observed. Thus, this GnRH antagonist is active in men even in small doses and could become a new therapeutic tool for sex hormone-dependent diseases. Cetrorelix seems to have the highest suppressive rate per mg peptide of all other antagonists from the literature, such as Nal-Glu (Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal3, Arg5, D-Glu6(AA), D-Alal0), Detirelix (Ac-D-Nal(2)1, D-pCl-Phe2, D-Trp3, D-hArg(Et2)6, D-Alal0) or 4F (Ac-delta 3Prol, 4F-D-Phe2, D-Trp3,6). During the time of suppression after a dose of 3 mg there was an LH and testosterone peak in the early morning coinciding with the testosterone peak in untreated men. The GnRH antagonist seems to unmask the circadian rhythm of LH secretion.
The effect of join selectives on optimal nesting order (1987)

A heuristic query optimizer must choose the best way to process an incoming query. This choice is based on comparing the expected cost of many (or all) of the ways that a command might be processed. This expected cost calculation is determined by statistics on the sizes of the relations involved and the selectivities of the operations being performed. Of course, such estimates are subject to error, and in this paper we investigate the sensitivity of the best query plan to errors in the selectivity estimates. We treat the common case of join queries and show that the optimal plan for most queries is very insensitive to selectivity inaccuracies. Hence, there is little reason for a data manager to spend a lot of effort making accurate estimates of join selectivities.
Utilizing a 3D game engine to develop a virtual design review system (2011)

A design review process is where information is exchanged between the designers and design reviewers to resolve any potential design related issues, and to ensure that the interests and goals of the owner are met. The effective execution of design review will minimize potential errors or conflicts, reduce the time for review, shorten the project life-cycle, allow for earlier occupancy, and ultimately translate into significant total project savings to the owner. However, the current methods of design review are still heavily relying on 2D paper-based format, sequential and lack central and integrated information base for efficient exchange and flow of information. There is thus a need for the use of a new medium that allow for 3D visualization of designs, collaboration among designers and design reviewers, and early and easy access to design review information. This paper documents the innovative utilization of a 3D game engine, the Torque Game Engine as the underlying tool and enabling technology for a design review system, the Virtual Design Review System for architectural designs. Two major elements are incorporated; 1) a 3D game engine as the driving tool for the development and implementation of design review processes, and 2) a virtual environment as the medium for design review, where visualization of design and design review information is based on sound principles of GUI design. The development of the VDRS involves two major phases; firstly, the creation of the assets and the assembly of the virtual environment, and secondly, the modification of existing functions or introducing new functionality through programming of the 3D game engine in order to support design review in a virtual environment. The features that are included in the VDRS are support for database, real-time collaboration across network, viewing and navigation modes, 3D object manipulation, parametric input, GUI, and organization for 3D objects.
Binding of Tris to Bacillus licheniformis &#945;-Amylase Can Affect Its Starch Hydrolysis Activity (2008)

Bacillus licheniformis alpha-amylase (BLA) is routinely used as a model thermostable amylase in biochemical studies. Its starch hydrolysis activity has recently been studied in Tris buffer. Here, we address the question that whether the application of Tris buffer may influence the results of BLA activity analyses. Based on the inhibition studies and docking simulations, we suggest that Tris molecule is a competitive inhibitor of starch-hydrolyzing activity of BLA, and it has a high tendency to bind the enzyme active site. Hence, it is critically important to consider such effect when interpreting the results of activity studies of this enzyme in Tris buffer.