gebhart/patrepeval huggingface dataset:
Characterization of a Nuclear Export Signal within the Human T Cell Leukemia Virus Type I Transactivator Protein Tax (2003)

Human T cell leukemia virus type I (HTLV-I) is the etiologic agent of adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. The HTLV-I transactivator protein Tax plays an integral role in the etiology of adult T cell leukemia, as expression of Tax in T lymphocytes has been shown to result in immortalization. In addition, Tax is known to interface with numerous transcription factor families, including activating transcription factor/cAMP response element-binding protein and nuclear factor-kappaB, requiring Tax to localize to both the nucleus and cytoplasm. In this report, the nucleocytoplasmic localization of Tax was examined in Jurkat, HeLa, and U-87 MG cells. The results reported herein indicate that Tax contains a leucine-rich nuclear export signal (NES) that, when fused to green fluorescent protein (GFP), can direct nuclear export via the CRM-1 pathway, as determined by leptomycin B inhibition of nuclear export. However, cytoplasmic localization of full-length Tax was not altered by treatment with leptomycin B, suggesting that native Tax utilizes another nuclear export pathway. Additional support for the presence of a functional NES has also been shown because the NES mutant Tax(L200A)-GFP localized to the nuclear membrane in the majority of U-87 MG cells. Evidence has also been provided suggesting that the Tax NES likely exists as a conditionally masked signal because the truncation mutant TaxDelta214-GFP localized constitutively to the cytoplasm. These results suggest that Tax localization may be directed by specific changes in Tax conformation or by specific interactions with cellular proteins leading to changes in the availability of the Tax NES and nuclear localization signal.
Two Angelman families with unusually advanced neurodevelopment carry a start codon variant in the most highly expressed <i>UBE3A</i> isoform (2018)

We present three children from two unrelated families with Angelman syndrome (AS) whose developmental skills are far more advanced than any other non-mosaic AS individual ever reported. All have normal gait and use syntactic language spontaneously to express their needs. All of them have a c.2T > C (p.Met1Thr) variant in UBE3A, which abrogates the start codon of isoform 1, but not of isoforms 2 and 3. This variant was maternally inherited in one set of siblings, but de novo in the other child from the unrelated family. This report underscores the importance of considering AS in the differential diagnosis even in the presence of syntactic speech.
A Sub-1-V Linear CMOS Bandgap Voltage Reference (2005)

Reference voltage generators with low sensitivity to the temperature and supply are commonly required both in analog and digital circuits. Since in the conventional bandgap reference circuit, the output voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ref</sub> is the sum of the built-in voltage of the diode V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> and the thermal voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of KT/q multiplied by a constant, thus V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ref</sub> is usually about 1.25 V, which limits a low supply-voltage operation below 1V. This paper presents a precise linear CMOS bandgap voltage reference circuit, which has low supply voltage. The proposed circuit is based on a novel architecture of two currents sum, one of which is proportional to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> and the other of which is proportional to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> . In addition, by properly selecting input voltage node for operational amplifier, the problem of low supply voltage is solved without complex low supply voltage amplifier. The simulated results for this circuit using Spectre of Cadence Corporation show that the temperature coefficient is about 30.67ppm/degC and that the whole circuit can successfully operate with sub-1-V supply
Cells Involved in Removing Liposomes from the Blood Circulation: Why Are They So Special? (1996)

In this contribution we describe and discuss (mostly published) experiments providing evidence favoring a decisive role of opsonizing plasma proteins in the removal of liposomes from the vascular compartment. Our conclusion is that cells will only bind and take up liposomes if they are anatomically accessible for the liposomes and if, in addition, they possess (specific) receptors for one or more proteins adsorbing to the liposomal surface. The relative contribution of each cell type fulfilling these criteria to over-all liposome clearance is dictated by the total number of cells in that population, the density of the receptor(s) involved, the affinity of those receptors for their respective ligands and the localization in the vascular system. It is concluded that only a few cell populations meet the criteria. Most are excluded because of inaccessibility while of the accessible ones several lack the proper opsonin receptors for significant liposome uptake. The significance of localization in the vasculature is illustrated by the hepatocytes whose accessibility is limited by the fenestrations in the endothelial lining of the liver sinusoids. The opsonin concept is extrapolated to cells other than macrophages; for example, the existence of hepatocyte-specific opsonins is proposed in order to explain the efficient uptake of small liposomes by this cell population. Because of their virtually complete lack of participation in plasma elimination of liposomes, some readily accessible cell types, such as the circulating blood cells and the vascular endothelial cells, are proposed to lack appropriate receptors. According to the views developed in this contribution the specialty of cells involved in liposome clearance therefore lies in the condition that they possess one or more receptors for plasma-derived proteins that spontaneously adsorb to the liposomal surface. One possible exception to the opsonin-determined concept is the fate of phosphatidylserine-containing liposomes. These may be cleared without or even in spite of involvement of opsonins, by virtue of a PS-specific receptor on macrophages.
Multiple Priority Region of Interest Coding with H.264 (2006)

This paper describes a modified rate control algorithm for H.264 that can accommodate multiple priority levels given a region of interest (Rol). The modified method allows better control of the quality of the RoI and gradual variation of the quality in the rest of the video frame through a bit redistribution process that is based on a number of parameters, including characteristics of the Rol, user input and perceptual factors.
A Heat Transfer and Chemical Reaction Rate Model of the lronmaking Blast Furnace (1988)

The flows of material and heat occurring within the ironmaking blast furnace are complex and highly coupled. A one dimensional model which predicts the heat transfer and chemical reactions in the blast furnace has been developed to provide a better understanding of these processes. The development and validation of this model have been aided by recent developments in blast furnace sensors which have allowed the measurement of gas compositions and temperatures within BHP blast furnaces. The model predictions have been found to substantially agree with these in-furnace measurements. In particular, the model has predicted the occurrence of two thermal reserve zones in regions near the wall. The model and furnace measurement, when taken together, give a greatly improved understanding of the gas distribution which occurs in these non-uniform packed bed reactors.
Multibolus stimulated echo imaging of coronary artery flow (1997)

One limitation of traditional bolus tagging techniques for MR angiography is the small amount of blood labeled by one tagging, resulting in a limited filling of the downstream vessels. We describe a multiple bolus technique using stimulated echoes (STE) for imaging coronary flow. A series of radiofrequency (RF) pairs are given with each pair selective at the region of tagging, thus tagging consecutive volumes of blood, and a final nonselective pulse is given to "read out" all of the tagged spins. In this way, multiple boluses of tagged blood are imaged at one time.
Potential Chemopreventive Agents Based on the Structure of the Lead Compound 2-Bromo-1-hydroxyphenazine, Isolated from <i>Streptomyces</i> Species, Strain CNS284 (2010)

The isolation of 2-bromo-1-hydroxyphenazine from a marine Streptomyces species, strain CNS284, and its activity against NF-κB, suggested that a short and flexible route for the synthesis of this metabolite and a variety of phenazine analogues should be developed. Numerous phenazines were subsequently prepared and evaluated as inducers of quinone reductase 1 (QR1) and inhibitors of quinone reductase 2 (QR2), NF-κB, and inducible nitric oxide synthase (iNOS). Several of the active phenazine derivatives displayed IC₅₀ values vs QR1 induction and QR2 inhibition in the nanomolar range, suggesting that they may find utility as cancer chemopreventive agents.
Above room temperature operation of short wavelength (λ=3.8μm) strain-compensated In0.73Ga0.27As–AlAs quantum-cascade lasers (2004)

We demonstrate the design and implementation of a broad-gain and low-threshold (Jth=860A∕cm2 at 8K) quantum-cascade laser emitting between 3.7 and 4.2μm. The active region design is based on strain-compensated In0.73Ga0.27As–AlAs on InP. Laser operation in pulsed mode is achieved up to a temperature of 330K with maximum single-facet output peak powers of 6W at 8K and 240mW at 296K. The temperature coefficient T0 is 119K.
<title>A Laser Calibrator-Compensator to Upgrade The Long-Term Accuracy of A Commercial Laser Interferometer</title> (1980)

This Calibrator-Compensator System was developed at Farrand Controls to satisfy a need for a practical measuring system with a long term accuracy of a few parts in ten million over distances up to 1.9 meters (75 inches). The inherent high accuracy of laser interferometers is limited by changes in the wavelength of light as a function of atmospheric temperature, pressure, and composition. The errors can exceed 13 PPM in air under constant temperature conditions. The best commercially available automatic compensator measures atmospheric variations with separate transducers, digitizes the data, and calculates the required correction factor. Since the remaining errors, typically 3 PPM, did not meet requirements, an improved compensation technique had to be developed. A reference optical path of known fixed length is used to determine the initial wavelength and to track changes in wavelength as they occur. The true wavelength of light is determined by evacuating the optical path to a modest vacuum and measuring the apparent path length change. The same optical path, open to the atmosphere, monitors the aggregate effect of all atmospheric changes without the use of separate transducers. The relative velocity of light is servoed to the reference path length, and the outputs of all axes of an Option 450 Hewlett-Packard laser interferometer are corrected. There is no cumulative error, and full accuracy is maintained over indefinitely extended intervals. Test runs of 50 to 90 hours have consistently shown total errors less than 3 parts in 10 million over path lengths of 0.25 to 1.9 meters (10 to 75 inches).
Appareillage destiné à l'étude de la thermoluminescence entre 77 K et 773 K (1975)

Nous décrivons un appareil permettant l'enregistrement des courbes de thermoluminescence d'échantillons minéraux ou organiques entre 77 K et 773 K avec des vitesses de chauffage pouvant aller jusqu'à 2 K/s. Ce dispositif, bien que conçu pour effectuer des mesures expérimentales de thermoluminescence, peut être utilisé pour des mesures dosimétriques de routine. Il permet l'étude de la thermoluminescence induite par différentes radiations ionisantes telles que le rayonnement gamma, les particules α, β et les ions lourds.
Flexible image sensor array with bulk heterojunction organic photodiode (2008)

Thick organic bulk heterojunction photodiodes with low dark current &lt;1nA∕cm2 and efficient charge collection are reported. An electric field &gt;1V∕μm is sufficient to achieve &gt;75% charge collection in films of poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene-vinylene] and [6,6]-phenyl-C61-butyric acid methyl ester blends up to 4μm thick, and the rate of photocurrent decay is reduced at saturation fields. The integration of a 4μm thick sensor layer onto a flexible amorphous silicon thin-film transistor backplane gave an image sensor array with 35% external quantum efficiency and noise equivalent power of 30pW∕cm2 at reverse bias voltage of −4V.
Video processing for single-chip DVB decoder (2001)

This paper deals with aspects of video processing for DVB decoder chips. The proposed architectures are implemented in a new DVB decoder IC. This IC comprises all units required for DVB decoding such as system demux, and MPEG video and audio decoder. To connect external devices it offers an ATAPI bridge, an IEEE1394 interface, and other interfaces. Conventional analog video is supported by an integrated color decoder and text slicer. The analog inputs and outputs allow easy integration in hybrid set-top box applications and integrated digital TV (IDTV) chassis. The first silicon is available.
Broadband optical ultrasound sensor with a unique open-cavity structure (2011)

High-resolution ultrasound imaging requires quality sensors with wide bandwidth and high sensitivity, as shown in a wide range of applications, including intravascular imaging of cardiovascular diseases. However, piezoelectric technology, the current dominant approach for hydrophone fabrication, has encountered many technical limitations in the high-frequency range. Using optical techniques for the detection of high-frequency ultrasound signals has attracted much recent attention. One of the most studied approaches is based on a Fabry-Pérot interferometer, consisting of an optical cavity sandwiched between two mirrors. This technique offers promising sensitivity and bandwidth, and a potential alternative to piezoelectric polyvinylidene fluoride (PVDF) hydrophones. We propose an innovative optical ultrasound sensor using only a single mirror in a total-internal-reflection configuration. Besides retaining the advantages of Fabry-Pérot interferometer-based ultrasound sensors, this unique design provides a bandwidth of at least 160 MHz, a potential decrease in fabrication cost, and an increase in signal fidelity.
A Randomized Trial of Exemestane after Two to Three Years of Tamoxifen Therapy in Postmenopausal Women with Primary Breast Cancer (2004)

Exemestane therapy after two to three years of tamoxifen therapy significantly improved disease-free survival as compared with the standard five years of tamoxifen treatment.
In Situ Tribocomponent Temperature Measurement Using a Radio Telemeter (1997)

A microradiotelemeter was designed and developed to measure the in situ temperature of a tribocomponent (tapered roller bearing roller). Photolithography was used to pattern a flexible circuit board for the telemeter. The overall device size was minimized by the use of surface-mount technology (SMT) components. The completed circuit board was 5 mm by 9 mm by 1.5 mm high and weighed approximately 0.080 grams. The board was packaged in a brass body with a battery case and antenna. The complete package was installed into a bearing roller, with the thermally sensitive elements near the rib-roller contact. The telemeter was used with an RF spectrum analyzer to monitor the start-up temperature of a bearing roller for various applied loads and shaft speeds. Test results indicate that, under starved conditions, the temperature of the roller measured with the telemeter increased significantly faster than the temperature of the housing.
Beating the limitations of camera-monitor mediated telepresence with extra eyes (1996)

Article Free Access Share on Beating the limitations of camera-monitor mediated telepresence with extra eyes Authors: Kimiya Yamaashi Hitachi Research Laboratory, Hitachi Ltd., 7-1-1 Omika-cho Hitachi-shi, Ibaraki-ken 319-12 Japan Hitachi Research Laboratory, Hitachi Ltd., 7-1-1 Omika-cho Hitachi-shi, Ibaraki-ken 319-12 JapanView Profile , Jeremy R. Cooperstock Telepresence Project, University of Toronto, 10 King's College Road, Toronto ON M5C 3G4, Canada Telepresence Project, University of Toronto, 10 King's College Road, Toronto ON M5C 3G4, CanadaView Profile , Tracy Narine Telepresence Project, University of Toronto, 10 King's College Road, Toronto ON M5C 3G4, Canada Telepresence Project, University of Toronto, 10 King's College Road, Toronto ON M5C 3G4, CanadaView Profile , William Buxton Telepresence Project, University of Toronto, 10 King's College Road, Toronto ON M5C 3G4, Canada and Alias/Wavefront, 110 Richmond Street East, Toronto ON M5C 1P1, Canada Telepresence Project, University of Toronto, 10 King's College Road, Toronto ON M5C 3G4, Canada and Alias/Wavefront, 110 Richmond Street East, Toronto ON M5C 1P1, CanadaView Profile Authors Info & Claims CHI '96: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsApril 1996 Pages 50–57https://doi.org/10.1145/238386.238402Published:13 April 1996Publication History 26citation738DownloadsMetricsTotal Citations26Total Downloads738Last 12 Months38Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Multiple biological activities of homogeneous human alpha interferon (1981)

To identify the active molecule in human alpha interferon preparations, we performed several studies, using both partially purified interferon and homogeneous interferon. Our results indicated that there is little difference between the partially purified and the homogeneous interferon preparations in terms of antiviral activity, inhibition of deoxyribonucleic acid synthesis in human neoplastic cells, and enhancement of human natural killer cell activity.
Gastroparesis and the gastric pacemaker: a revolutionary treatment for an old disease. (2002)

Gastroparesis--or delayed gastric emptying--can apply to either solids or liquids but the term (gastroparesis) usually refers to delayed solid emptying, in an appropriate clinical setting. Impaired gastric emptying can occur acutely in a variety of conditions from neurologic to metabolic. Intractable nausea and vomiting, and the inability to tolerate oral intake, occurs frequently in patients with severe gastroparesis. The patients' nutritional status is adversely affected by gastroparesis as are the socioeconomic aspects of patient's lives. The previous treatments of gastroparesis, such as medications and surgery, were often not successful. Our recent understanding of the normal gastric electro-mechanical function and its abnormalities/dysrythmias has led to the development of a gastric electrical stimulator, analagous to other devices used to stimulate dysfunctional organs. Gastric electrical stimulation is associated with improvements in symptomatic relief, nutritional status, health resource utilization and costs and is now approved by the FDA as a humanitarian use device. It offers a new and hopeful therapy for patients with refractory gastroparesis where none have existed before.
Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology (2011)

A comparison between glass slides, plain PDMS, and nanotextured PDMS functionalized with aptamers demonstrated that a 2-fold approach of using aptamers on nanotextured PDMS can be important for cancer cytology devices, and especially for the idea of a "lab-on-chip," toward higher yield in capture efficiency.
The Single-Carrier and Multi-Carrier Technology in Terrestrial Digital TV (2005)

The paper introduces the basic concept of single-carrier system and multi-carrier system in terrestrial digital transmission technology,and discusses the ATSC standards based on a single-carrier system,DVB-T standards based on a multi-carrier system as well as ADTB-T standards based on a single-carrier Time Domain Synchronous technology.
Microneedling with dermaroller (2009)

Microneedling with dermaroller is a new treatment modality for the treatment of scars, especially acne scars, stretch marks, wrinkles, and for facial rejuvenation. It is a simple and relatively cheap modality that also can be used for transdermal drug delivery.
Oxygen: the poison is in the dose (2012)

Cell-free hemoglobin (Hb) has been blamed for a spectrum of problems, including vasoconstriction pancreatitis, myocardial infarction, and pulmonary hypertension in hemolytic anemia, malaria, and sickle cell anemia, and from Hb-based oxygen carriers (HBOCs). Toxicities have been attributed to scavenging of nitric oxide (NO). However, while NO scavenging may explain many in vitro effects, and some effects in animal models and clinical trials with HBOCs, key inconsistencies in the theory require alternative explanations. This review considers the hypothesis that cell-free Hb oversupplies oxygen to tissues, leading to oxygen-related toxicity, possibly through formation of reactive oxygen species and local destruction of NO. Evidence for this hypothesis comes from various sources, establishing that tissue oxygen levels are maintained over very narrow (and low) levels, even at high oxygen consumption. Tissue is normally protected from excessive oxygen by its extremely low solubility in plasma, but introduction of cell-free Hb, even at low concentration, greatly augments oxygen supply, engaging protective mechanisms that include vasoconstriction and ischemia. The requirement to limit oxygen supply by cell-free Hb suggests novel ways to modify it to overcome vasoconstriction, independent of the intrinsic reaction of Hb with NO. This control is essential to the design of a safe and effective cell-free HBOC.