gebhart/patrepeval huggingface dataset:
WELCOME &#x2014; Innovative integrated care platform using wearable sensing and smart cloud computing for COPD patients with Comorbidities (2014)

We propose WELCOME, an innovative integrated care platform using wearable sensors and smart cloud computing for Chronic Obstructive Pulmonary Disease (COPD) patients with co-morbidities. WELCOME aims to bring about a change in the reactive nature of the management of chronic diseases and its comorbidities, in particular through the development of a patient centred and proactive approach to COPD management. The aim of WELCOME is to support healthcare services to give early detection of complications (potentially reducing hospitalisations) and the prevention and mitigation of comorbidities (Heart Failure, Diabetes, Anxiety and Depression). The system incorporates patient hub, where it interacts with the patient via a light vest including a large number of non-invasive chest sensors for monitoring various relevant parameters. In addition, interactive applications to monitor and manage diabetes, anxiety and lifestyle issues will be provided to the patient. Informal carers will also be supported in dealing with their patients. On the other hand, welcome smart cloud platform is the heart of the proposed system where all the medical records and the monitoring data are managed and processed via the decision support system. Healthcare professionals will be able to securely access the WELCOME applications to monitor and manage the patient's conditions and respond to alerts on personalized level.
Design Concepts for Developing Highly Efficient Chiral Bisphosphine Ligands in Rhodium-Catalyzed Asymmetric Hydrogenations (1992)

Several efficient asymmetric hydrogenations catalyzed by chiral bisphosphine-rhodium complexes were developed with the modification of bisphosphine ligands on the basis of our designing concept. 1. Introduction 2. The Respective Control Concept. A Proposal for the Development of Highly Efficient Chiral Bisphosphine Ligands 2.1. Preliminary Considerations 2.2. The Design of the Highly Efficient Bisphosphine Ligand BCPM 2.3. Experimental Confirmation of the Respective Control Concept 3. Application of the Designing Concept to C 2-Symmetric Bisphosphines 3.1. Development of Modified DIOP Ligands 3.2. Application to 1,2- and 1,3-Substituted Bisphosphines 3.3. Newly Designed 1,3-Substituted Bisphosphines 4. Application to the Practical Asymmetric Syntheses of Optically Active Medicines 5. Mechanistic Considerations of the Basis of the Correlation between Chirality of the Catalyst and Absolute Configuration of the Hydrogenation Product 5.1. Mechanism of Asymmetric Hydrogenation of Olefins 5.2. Mechanism of Asmmetric Hydrogenation of Ketones 6. Conclusion
Prediction of histological stage based on cystoscopic appearances of newly diagnosed bladder tumours (2016)

INTRODUCTION In the 75-80% of urothelial bladder cancers (UBC) presenting as non-muscle invasive bladder cancer (NMIBC), transurethral resection of bladder tumour (TURBT) is the key treatment and staging procedure. In the 20-25% of patients with muscle invasive bladder cancer (MIBC), further cross-sectional imaging is required to complete the staging process before considering radical treatment. Given the adverse effects of ionising radiation, clinicians identify patients believed to have MIBC, and so requiring further imaging pre-TURBT, at the tumour histology/stage based on the tumour's visual characteristics. There is minimal evidence describing the accuracy of such predictions in newly-diagnosed patients. METHODS Over a 6-year period, a database of patients undergoing resection of newly-diagnosed bladder lesions in a single UK centre was prospectively established. Predictions based on histology were simultaneously recorded, and the accuracy of these predictions of histology/stage subsequently assessed. RESULTS One hundred and twenty two (73.1%) patients with histologically confirmed NMIBC had predictions recorded versus 45 (26.9%) patients with MIBC. Visual assessment predictions of MIBC had a sensitivity of 88.9% (95% confidence interval [CI] 76.5%-95.2%) and a specificity of 91.0% (95% CI 84.6%-94.9%), giving a positive predictive value of 78.4% (95% CI 65.4%-87.5%) and a negative predictive value of 95.7% (95% CI 90.3%-98.1%). CONCLUSIONS We find that visual assessment is accurate in predicting the presence of MIBC. This supports the practice of stratifying patients at the time of initial cystoscopy for those requiring further radiological staging pre-TURBT.
Fast Implementations of Nonparametric Curve Estimators (1994)

Abstract Recent proposals for implementation of kernel-based nonparametric curve estimators are seen to be faster than naive direct implementations by factors up into the hundreds. The main ideas behind the two different approaches are made clear. Careful speed comparisons in a variety of settings and using a variety of machines and software are done. Various issues on computational accuracy and stability are also discussed. Our speed tests show that the fast methods are as fast or somewhat faster than methods traditionally considered very fast, such as LOWESS and smoothing splines.
International HARM Precision Navigation Upgrade. A GPS/INS missile upgrade that improves effectiveness and minimizes friendly-fire accidents (2003)

The High Speed Anti-radiation Missile (HARM) is an air to surface tactical missile designed to seek and destroy enemy radar-equipped air defense systems. Unfortunately, the HARM is "no respector of persons", and it has been known, most notably during the Gulf War, to attack "friendly" targets. The international HARM Upgrade Project is a tri-national missile technology project sponsored by the United States, Italian, and German governments. The HARM Precision Navigation Upgrade (PNU) program has as its goal, the development and installation of a PNU into the HARM that will improve the weapon's effectiveness, while nearly eliminating the likelihood of fratricide. The precision navigation system consists of a modem SAASM (Selective Availability Anti-Spoofing Module) based Global Positioning System (GPS) receiver (NavStrike/sup TM/, Rockwell Collins Government Systems), and an Inertial Measurement Unit (IMU), consisting of state-of-the-art Fiber Optic Gyros (FOG MFORS-1, Litef) and modem micro-machined accelerometers (B-290 Triad, Litef).
Therapeutic Potential of Adipose-Derived SSEA-3-Positive Muse Cells for Treating Diabetic Skin Ulcers (2015)

Stage-specific embryonic antigen-3 (SSEA-3)-positive multipotent mesenchymal cells (multilineage differentiating stress-enduring [Muse] cells) were isolated from cultured human adipose tissue-derived stem/stromal cells (hASCs) and characterized, and their therapeutic potential for treating diabetic skin ulcers was evaluated. Cultured hASCs were separated using magnetic-activated cell sorting into positive and negative fractions, a SSEA-3+ cell-enriched fraction (Muse-rich) and the remaining fraction (Muse-poor). Muse-rich hASCs showed upregulated and downregulated pluripotency and cell proliferation genes, respectively, compared with Muse-poor hASCs. These cells also released higher amounts of certain growth factors, particularly under hypoxic conditions, compared with Muse-poor cells. Skin ulcers were generated in severe combined immunodeficiency (SCID) mice with type 1 diabetes, which showed delayed wound healing compared with nondiabetic SCID mice. Treatment with Muse-rich cells significantly accelerated wound healing compared with treatment with Muse-poor cells. Transplanted cells were integrated into the regenerated dermis as vascular endothelial cells and other cells. However, they were not detected in the surrounding intact regions. Thus, the selected population of ASCs has greater therapeutic effects to accelerate impaired wound healing associated with type 1 diabetes. These cells can be achieved in large amounts with minimal morbidity and could be a practical tool for a variety of stem cell-depleted or ischemic conditions of various organs and tissues.
Sequence and function of the aas gene in Escherichia coli. (1994)

2-Acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase and acyl-acyl carrier protein (acyl-ACP) synthase activities are encoded by the aas gene in Escherichia coli. The aas gene was cloned, and the DNA sequence of the aas gene and the region between aas and galR established the clockwise gene order in the 61.2 min of the E. coli chromosome as aas-orf-galR-lysA-lysR-orf-araE. The aas gene consists of a single open reading frame of 2,157 base pairs predicted to encode a protein of 80.6 kDa. Strains harboring multiple copies of the aas gene overproduced both 2-acyl-GPE acyltransferase and acyl-ACP synthetase activities in vitro and had higher specific activities for the incorporation of exogenous fatty acids and lysophospholipids into the membrane in vivo. Specific expression of the aas gene yielded a protein with an apparent molecular mass of 81 kDa. Comparison of the predicted amino acid sequence of the aas gene with mammalian, yeast, and bacterial long chain acyl-coenzyme A synthetases revealed three domains of high similarity which are postulated to form the acyl-AMP binding pocket. These data verify that 2-acyl-GPE acyltransferase and acyl-ACP synthetase are reactions carried out by the same gene product, verify the role of 2-acyl-GPE acyltransferase/acyl-ACP synthetase in the acylation of endogenous 2-acyl-GPE, and establish the product of the aas gene as the rate-limiting enzyme in the uptake and incorporation of exogenous 2-acyllysophospholipids.
Human Chorionic Gonadotropin (HCG) Activates Monocytes to Produce Interleukin-8 via a Different Pathway from Luteinizing Hormone/HCG Receptor System (2002)

Abstract To investigate immune-endocrine interactions between the embryo and the mother early in pregnancy, we examined the effects of human chorionic gonadotropin (HCG) on IL-8 production by peripheral blood mononuclear cells (PBMC). Recombinant HCG promoted IL-8 secretion by PBMC derived from nonpregnant women. The induction of IL-8 mRNA expression was observed after 30 min of HCG stimulation. Adsorption of the HCG with anti-HCG antibodies confirmed the specificity of this effect. The translocation of nuclear factor κB into the nucleus and subsequent IL-8 production were observed mainly in monocytes, and IL-8 production was reduced when a proteasome inhibitor was added to inactivate nuclear factor κB. Although fluorescein isothiocyanate-labeled HCG was bound to the majority of monocytes, cell surface expression of HCG receptor was hardly detected. IL-8 production by HCG was not affected by inhibitors of protein kinases A and C. In contrast, this stimulation was attenuated by d-mannose, which inhibits binding to C-type lectins. The basal IL-8 production by PBMC from women early in pregnancy was significantly elevated, compared with that from nonpregnant women. This study showed that human monocytes respond to HCG and secrete IL-8 through a pathway different from the HCG receptor system, suggesting that this glycoprotein hormone can react with not only endocrine cells but also immune cells early in pregnancy, probably via primitive systems such as C-type lectins.
Implementation and Evaluation of Raptor Codes on Embedded Systems (2010)

Raptor codes have been proven very suitable for mobile broadcast and multicast multimedia content delivery, and yet their computational complexity has not been investigated in the context of embedded systems. At the heart of Raptor codes are the matrix inversion and vector decoder operations. This paper analyzes the performance, energy profile, and resource implication of two matrix inversion and decoding algorithms; Gaussian elimination (GE) and third Generation Partnership Group (3GPP) standard (SA), for the Raptor decoder on a system on a chip (SoC) platform with a soft-core embedded processor. We investigate the effect of the cache size, memory type, and mapping on the performance of the two algorithms under consideration. We show that with an appropriate data to memory mapping, a speedup factor of 5.77 can be obtained for GE with respect to SA. This paper also proposes a dedicated peripheral hardware block that achieves 5.90 times better performance compared with the software, requiring an energy consumption that is lower by a factor of 5.5, when the symbol size and the data path word length are small (32 bits). We show that with parallel processing in hardware, using the wider word lengths, and employing bigger symbol sizes T, we can improve the performance, while reducing the energy consumption. Extending the hardware word length and symbol size T to 128 bits will result in a performance improvement factor of 6.73 in favor of the hardware; while energy consumption reduces by a factor of 3.8.
Research on the quick proofing process of carton (2010)

Article describes a kind of the quick proofing process of carton. The digital mode of the quick proofing process of carton is scientific practical and accuracy, which is based on computer-aided design (CAD) technology. It can design carton Structure profile, which can be virtually proofed in the software. Combined digital proofing with digital mould technology, it can build a integration mode of software and hardware of carton device . Using the program to drive carton device,it can be realized that the digital proofing and cutting and creasing process of carton.
Synthesis and Characterization of Novel Polyisobutylene-Based Materials: Gradient Block Copolymers, Exo-Olefins Via In Situ Quenching, and Carboxylic Acid-Functional Telechelics (2007)

The therapeutic potential of enzyme replacement in lysosomal storage disorders has remained largely unfulfilled, perhaps because of negative reactions to the initial disappointing results. Despite the existence of several animal models that can be utilized to explore solutions to the problems of exogenous enzyme targeting, the interest in ERT prevalent during the 1970's seems to have subsided to be replaced by active interest in bone marrow transplantation (BMT, Krivit and Paul [1986]). This is a logical approach to enzyme replacement in storage disorders of the RE system, and indeed some encouraging results have been obtained. However, in addition to having high morbidity and mortality, in the ultimate analysis BMT presents the same targeting problems as conventional ERT. In our opinion, these problems can be solved more easily in the case of ERT by exploiting the existing cellular uptake mechanisms and infusing enzymes whose structure has been suitably modified by simple biochemical manipulations. Accordingly, we have explored a methodology that takes advantage of negative charges on the cell surface to obtain nonspecific but effective membrane binding of beta-hex coupled to the highly positively charged PLL, followed by internalization and routing to the lysosomes. This system increases uptake of exogenous enzyme by some neurons in vitro and possibly in vivo, but its efficiency depends on the cells' endocytic activity that, in the case of neuronal soma, apparently is low. Thus, we have chosen as recognition marker for specific neuronal uptake a nontoxic fragment of TTx that is efficiently taken up by these cells. The initial results are encouraging; they support our contention that effective enzyme replacement methodologies can be devised, and encourage us to continue our work in this direction. Finally, recombinant DNA techniques are now being applied to a number of LSD, and the genes for several of the pertinent enzymes have been or are being isolated. In addition to representing a first step towards gene replacement therapy, the results of this work will permit the generation of large amounts of human enzymes from bacteria by recombinant DNA methods, thus obviating the problem of enzyme supply for ERT. Since human lysosomal enzymes obtained from bacteria will be nonglycosylated, to obtain cell uptake it will be necessary to resort to the type of modifications that we are trying to develop at this time, i.e., covalent linkage to moieties that allow non-glycosyl-mediated cellular uptake. Thus, our work on beta-hex may provide a model for biochemical manipulations of bacterially produced enzymes applicable to several LSD.
Differential Flap Dynamics in Wild-Type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation (2012)

In the rapidly evolving disease of HIV drug resistance readily emerges, nullifying the effectiveness of therapy. Drug resistance has been extensively studied in HIV-1 protease where resistance occurs when the balance between enzyme inhibition and substrate recognition and turn-over is perturbed to favor catalytic activity. Mutations which confer drug resistance can impact the dynamics and structure of both the bound and unbound forms of the enzyme. Flap+ is a multi-drug-resistant variant of HIV-1 protease with a combination of mutations at the edge of the active site, within the active site, and in the flaps (L10I, G48V, I54V, V82A). The impact of these mutations on the dynamics in the unliganded form in comparison with the wild-type protease was elucidated with Molecular Dynamic simulations and NMR relaxation experiments. The comparative analyses from both methods concur in showing that the enzyme's dynamics are impacted by the drug resistance mutations in Flap+ protease. These alterations in the enzyme dynamics, particularly within the flaps, likely modulate the balance between substrate turn-over and drug binding, thereby conferring drug resistance.
Towards inducing stimulus generation directives from functional coverage data (2005)

Coverage Directed test Generation (CDG) is a technique that aims to automate the generation of simulation stimuli based on coverage information. This paper presents a novel approach to CDG which is based on inductive learning from examples, in particular Inductive Logic Programming (ILP). The ILP-based CDG methodology takes tests and associated coverage data, some relational background knowledge and a coverage task as learning goal. It produces rules which describe the general structure of tests that achieve the target coverage task. As a first step a rediscovery experiment has been conducted with the aim to show that, given a set of pseudo-randomly generated tests together with their coverage, it is possible to induce rules, at least one per coverage task reached, that correctly characterize the features of tests to target the achieved coverage. The success of this rediscovery experiment confirms the validity of the ILP-based CDG methodology. It establishes the foundations for automatically closing functional coverage metrics using ILP.
Characterization of a Battery of Monoclonal Antibodies for Differentiation of Newcastle Disease Virus and Pigeon Paramyxovirus-1 Strains (1988)

Twenty monoclonal antibodies (MCAs) prepared against the velogenic GB-Texas strain of Newcastle disease virus (NDV) and the type 1 pigeon paramyxovirus (PPMV-1) were characterized and examined as potential immunodiagnostic reagents. All MCAs generated were found to bind specifically, but with varying reactivity, to various NDV strains in direct binding assays. In addition, MCA 15C4 neutralized and inhibited hemagglutination (HA) of all lentogenic, mesogenic, and velogenic NDV strains tested but not the PPMV-1 strain. Antibody 10D11 also inhibited HA activity, but inhibition was more selective and limited to the mesogenic and domestic or indigenous velogenic strains of NDV. MCA 79 reacted in all serologic assays with an antigenic site common to all serotype 1 avian paramyxoviruses. Passive immunization studies involving three different neutralizing MCAs (35, 79, and 15C4) showed that enhanced, but not complete, protection against virulent NDV challenge was provided when the three MCAs were administered in combination.
Advances in Phosphors for Light-emitting Diodes (2011)

Light-emitting diodes (LEDs) are excellent candidates for general lighting because of their rapidly improving efficiency, durability, and reliability, their usability in products of various sizes, and their environmentally friendly constituents. Effective lighting devices can be realized by combining one or more phosphor materials with chips. Accordingly, it is very important that the architecture of phosphors be developed. Although numerous phosphors have been proposed in the past several years, the range of phosphors that are suitable for LEDs is limited. This work describes recent progress in our understanding of the prescription, morphology, structure, spectrum, and packaging of such phosphors. It suggests avenues for further development and the scientific challenges that must be overcome before phosphors can be practically applied in LEDs.
Flow Rate Effect on Two-Phase Relative Permeability In Iranian Carbonate Rocks (2007)

Abstract The effect of flow rate on relative permeability curves has been investigated in very tight Iranian carbonate rocks. Core samples were prepared from outcrop of Asmari formation. Asmari formation represents huge oil carbonate reservoirs in Iran. This formation belongs to Oligocene-Miocene period and is mainly limestone. The dynamic displacement experiments were performed at three different flow rates. In all experiments, we injected both water to displace oil and oil to displace water and relative permeability curves were generated with the Jones and Roszelle method for both water-flooding and oil-flooding experiments. We found a critical rate in which we could not obtain any relative permeability curves above this rate. This critical rate represents the limit of injectivity capacity of each core sample. We observed that in the water-flooding process, water relative permeability curves and its end points were not affected by flow rate. However, it was detected that the oil relative permeability decreases at lower flow rates. This variation vanishes at the central saturation points. During oil-flooding experiments, we also observed the same no rate effect in water relative permeability curve but in the oil relative permeability curves, although it was seen the flow rate effect, it was not found any meaningful trend in the curves and its end-point saturations. We found hysteresis effect in both water and oil relative permeability curves. At higher flow rates, the effect of this phenomenon increases in water relative permeability curves while the hysteresis effect decreases in the oil relative permeability curves.