gebhart/patrepeval huggingface dataset:
Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts (2000)

p21-activated kinases (Paks) are effectors of the small GTPases Cdc42 and Rac, and are thought to mediate some of the cytoskeletal and transcriptional activities of these proteins. To localize activated Pak1 in cells, we developed an antibody directed against a phosphopeptide that is contained within the activation loop of Pak1. This antibody specifically recognizes the activated form of Pak1. Immunofluorescence analysis of NIH-3T3 cells coexpressing activated Cdc42 or Rac1 plus wild-type Pak1 shows that activated Pak1 accumulates at sites of focal adhesion, throughout filopodia and within the body and edges of lamellipodia. Platelet-derived growth factor stimulation of NIH-3T3 cells shows a pattern of Pak1 activation similar to that observed with Rac1. During closure of a fibroblast monolayer wound, Pak1 is rapidly activated and localizes to the leading edge of motile cells, then gradually tapers off as the wound closes. The activation of Pak1 by wounding is blocked by inhibitors of phosphatidylinositol 3-kinase, and Src family kinases, but not by an inhibitor of the epidermal growth factor receptor. These findings indicate that activated Pak1, and by extension, probably activated Cdc42 or Rac, accumulates at sites of cortical actin remodeling in motile fibroblasts.
Absence of an effect of terfenadine on guinea pig brain histamine H1-receptors in vivo determined by receptor binding techniques. (1982)

Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.) inhibition of the in vitro binding of [3H]mepyramine to histamine H1-receptors prepared from guinea pig brain and ileum was characterized under several experimental conditions. After an intraperitoneal injection of 5 mg/kg of either terfenadine or chlorpheniramine, brain and ileum were obtained to determine in vitro the binding of [3H]mepyramine to histamine H1-receptors. While the binding of ligand to receptors from the ileum of both terfenadine and chlorpheniramine treated animals was almost completely inhibited, the ligand binding to receptors from brains of chlorpheniramine treated but not terfenadine treated animals was affected. When terfenadine was added to receptor homogenates from guinea pig brain and ileum, it antagonized the binding of [3H]mepyramine to receptors from both tissues. The potency of terfenadine antagonism of ligand binding was similar to both ileal (IC50, 200 nmol/l) and brain (IC50, 300 nmol/l) receptors. The kinetics of in vitro antagonism by terfenadine of [3H]mepyramine binding to receptors is unique in that antagonism of ligand binding by terfenadine was enhanced by a longer incubation of the receptors with this drug and H1-receptor blockade by terfenadine could not be reversed by extensive washing of these receptors at 25 degrees C. These results show that terfenadine treatment does not result in sufficient levels in the brain to inhibit central histamine receptors at a dose which overwhelmingly inhibits histamine receptors in peripheral tissue. It is proposed that terfenadine slowly associates with the H1-receptor and forms a stable complex from which it dissociates quite slowly.
The bloodhound project (2003)

According to usability experts, the top user issue for Web sites is difficult navigation. We have been developing auto-mated usability tools for several years, and here we describe a prototype service called InfoScent™ Bloodhound Simula-tor, a push-button navigation analysis system, which auto-matically analyzes the information cues on a Web site to produce a usability report. We further build upon previous algorithms to create a method called Information Scent Absorption Rate, which measures the navigability of a site by computing the probability of users reaching the desired destinations on the site. Lastly, we present a user study involving 244 subjects over 1385 user sessions that show how Bloodhound correlates with real users surfing for in-formation on four Web sites. The hope is that, by using a simulation of user surfing behavior, we can reduce the need for human labor during usability testing, thus dramatically lower testing costs, and ultimately improving user experience. The Bloodhound Project is unique in that we apply a concrete HCI theory directly to a real-world prob-lem. The lack of empirically validated HCI theoretical model has plagued the development of our field, and this is a step toward that direction.
Evaluation of 0.75% metronidazole gel in acne-a double-blind study (1994)

Metronidazole, an imidazole, is an antibiotic with established efficacy against anaerobic bacteria. To date, however, there are no published data concerning the efficacy of topical metronidazole in the treatment of acne. This randomized, double-blind prospective clinical study of 96 patients was performed to investigate the efficacy and tolerability of 0.75% metronidazole gel vs. placebo in the treatment of mild to moderate acne. The results of this study showed no significant benefit in using 0.75% metronidazole gel over placebo in reducing counts of inflamed and non-inflamed lesions of acne. There was also no statistically significant difference between the two groups at any stage in the trial when skin tolerability was assessed.
Steep-Slope Devices: Prospects and Challenges (2016)

In this work, an overview is given on the prospects and challenges of two novel device concepts,namely the Tunnel FET (TFET) and the Superlattice FET (SL-FET). The optimization effort ofhomo- and hetero-junction TFETs carried out so far shows that these devices can provide an advantageover CMOS FETs only for very-low power and low-performance niche applications, so long asthe supply voltage is scaled below 300 mV. The required materials for homojunction TFETs are lowbandgap semiconductors, such as InAs and InGaAs; for heterojunction TFETs the best semiconductorpair appears to be (Al)GaSb-InAs. Several technological problems are still unsolved: poor qualityof the oxide interface with III-V materials and device variability are probably the most important. The SL-FET represents in principle a better device concept, as it provides outstanding performance and meets nearly all targets of the high performance (HP), low operating power (LOP) and low standby power (LSTP) of the ITRS at V DD = 0.4V. A suitably-designedInGaAs-InAlAs SL-FET has turned out to provide the best simulation results. However, the fabricationprocess of SL-FETs is much more complex, as it requires molecular epitaxy to deposit multiplelayers with a very strict control of their nanometric thickness. Besides, vertical devices can poseunexpected problems as far as layout organization and parasitics are concerned.
Indel and Carryforward Correction (ICC): a new analysis approach for processing 454 pyrosequencing data (2013)

Source code is freely available for download at http://indra.mullins.microbiol.washington.edu/ICC. It is implemented in Perl and supported on Linux, Mac OS X and MS Windows.
Distributed TSV Topology for 3-D Power-Supply Networks (2011)

3-D integration has the potential to increase performance and decrease energy consumption. However, there are many unsolved issues in the design of these systems. In this work we study the design of 3-D power supply networks and demonstrate a technique specific to 3-D systems that improves IR-drop and dynamic noise over a straightforward extension of traditional design techniques. Previous work in 3-D power delivery network design has simply extended 2-D techniques by treating through-silicon vias (TSVs) as extensions of the C4 bumps. By exploiting the smaller size and much higher interconnect density possible with TSVs we demonstrate significant reduction of nearly 50% in the IR-drop and 42% in the dynamic noise of our large-scale 3-D design. Simulations also show that a 3-tier stack with the distributed TSV topology actually lowers IR-drop by 21% and dynamic noise by 32% over a non-3-D system with less power dissipation. We analyze the power distribution network of an envisioned 1000-core processor with 30 stacked dies and show scaling trends related to both increased stacking and power distribution TSVs. Finally, we examine several techniques for minimizing IR-drop and dynamic noise and their effects on our large-scale 3-D system.
Prediction models for wind speed at turbine locations in a wind farm (2011)

ABSTRACT In wind farms, individual turbines disturb the wind field by generating wakes that influence other turbines in the farm. From a control point of view, there is an interest in dynamic optimization of the balance between fatigue and production, and an understanding of the relationship between turbines manifested through the wind field is hence required. This paper develops models for this relationship. The result is based on two new contributions: the first is related to the estimation of effective wind speeds, which serves as a basis for the second contribution to wind speed prediction models. Based on standard turbine measurements such as rotor speed and power produced, an effective wind speed, which represents the wind field averaged over the rotor disc, is derived. The effective wind speed estimator is based on a continuous–discrete extended Kalman filter that takes advantage of nonlinear time varying turbulence models. The estimator includes a nonlinear time varying wind speed model, which compared with literature results in an adaptive filter. Given the estimated effective wind speed, it is possible to establish wind speed prediction models by system identification. As the prediction models are based on the result related to effective wind speed, it is possible to predict wind speeds at neighboring turbines, with a separation of over 700 m, up to 1 min ahead reducing the error by 30% compared with a persistence method. The methodological results are demonstrated on data from an off‐shore wind farm. Copyright © 2011 John Wiley & Sons, Ltd.
Fast offset compensation for a 10Gbps limit amplifier (2004)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.
<i>Morphogenics</i> as a Tool for Target Discovery and Drug Development (2005)

A bstract : Mutations in DNA mismatch repair (MMR) genes lead to genetically hypermutable cells. Germline mutations in MMR genes in man have been linked to the genetic predisposition to hereditary nonpolyposis colon cancer and a number of other inherited and sporadic malignancies. The ability to modulate the MMR process (referred to as morphogenics ) in model systems offers a powerful tool for generating functional diversity in cells and multicellular organisms via the perpetual genomewide accumulation of randomized point and slippage mutation(s). Morphogenics is a platform process that employs a dominant negative MMR gene to create genetic diversity within defined cellular systems and results in a wide range of phenotypes, thus enabling the development and improvement of pharmaceutical products and the discovery of new pharmaceutical targets. Libraries of morphogenics ‐derived siblings are generated through random mutagenesis from naturally occurring DNA polymerase‐induced mutations that occur during DNA replication. Morphogenic cells are screened in high‐throughput assays to identify subclones with desired phenotypes for pathway discovery and/or product development. Morphogenics has been successfully applied to a wide range of hosts, including mammalian cells, transgenic mice, plants, yeast, and bacteria. Manipulation of these systems via morphogenics has led to the discovery of novel disease‐associated phenotypes in targeted model systems. Moreover, morphogenics has been successfully applied to antibody‐producing cell lines to yield subclones producing antibodies with enhanced binding affinities for therapeutic use, as well as to derive subclones with enhanced titers that are suitable for scaleable manufacturing. The selective manipulation of the MMR process via morphogenics is a platform technology that offers many advantages for the discovery of druggable targets, as well as for the development of novel pharmaceutical products.
Substituent effects on cation–π interactions: A quantitative study (2002)

A synthetic supramolecular complex has been adapted to quantify cation-pi interactions in chloroform by using chemical double-mutant cycles. The interaction of a pyridinium cation with the pi-face of an aromatic ring is found to be very sensitive to the pi-electron density. Electron-donating substituents lead to a strong attractive interaction (-8 kJ/mol(-1)), but electron-withdrawing groups lead to a repulsive interaction (+2 kJ/mol(-1)).
PIEZOELECTRIC CANTILEVER MICROPHONE AND MICROSPEAKER (1994)

A micromachined piezoelectric cantilever transducer, which works both as a microphone and as a microspeaker, has been fabricated and tested. The 2000/spl times/2000/spl times/4.5 /spl mu/m/sup 3/ cantilever has a zinc oxide (ZnO) piezoelectric thin film on a supporting layer of low-pressure chemical-vapor-deposited (LPCVD) low-stress silicon nitride. A highlight of the fabrication process, which may also be relevant for other micromachined structures, is the technique for producing a flat, multilayer cantilever. The measured microphone sensitivity is fairly constant at 3 mV//spl mu/bar in the low frequency range and rises to 20 mV//spl mu/bar at the lowest resonant frequency of 890 Hz. The 3 mV//spl mu/bar sensitivity is the highest reported to date for a microphone with a micromachined diaphragm. When measured into a 2 cm/sup 3/ coupler with 4 V(zero-peak) drive, the microspeaker output sound pressure level (SPL) is 75 dB at 890 Hz. It increases to approximately 100 dB SPL at 4.8 kHz with 6 V(zero-peak) drive. The measured microphone frequency response agrees well with the results of an ABAQUS simulation.
Low-Dose Interleukin-2 Therapy: A Driver of an Imbalance between Immune Tolerance and Autoimmunity (2014)

For many years, the role of interleukin-2 (IL-2) in autoimmune responses was established as a cytokine possessing strong pro-inflammatory activity. Studies of the past few years have changed our knowledge on IL-2 in autoimmune chronic inflammation, suggesting its protective role, when administered at low-doses. The disrupted balance between regulatory and effector T cells (Tregs and Teffs, respectively) is a characteristic of autoimmune diseases, and is dependent on homeostatic cytokines, including IL-2. Actually, inherent defects in the IL-2 signaling pathway and/or levels leading to Treg compromised function and numbers as well as Th17 expansion have been attributed to autoimmune disorders. In this review, we discuss the role of IL-2 in the pathogenesis of autoimmune diseases. In particular, we highlight the impact of the dysregulated IL-2 pathway on disruption of the Treg/Th17 balance, reversal of which appears to be a possible mechanism of the low-dose IL-2 treatment. The negative effects of IL-2 on the differentiation of follicular helper T cells (Tfh) and pathogenic Th17 cells, both of which contribute to autoimmunity, is emphasized in the paper as well. We also compare the current IL-2-based therapies of animal and human subjects with immune-mediated diseases aimed at boosting the Treg population, which is the most IL-2-dependent cell subset desirable for sufficient control of autoimmunity. New perspectives of therapeutic approaches focused on selective delivery of IL-2 to inflamed tissues, thus allowing local activity of IL-2 to be combined with its reduced systemic and pleiotropic toxicity, are also proposed in this paper.
Separation by plasma implantation of oxygen (SPIMOX) operational phase space (1997)

Separation by plasma implantation of oxygen (SPIMOX) has been suggested as an economic alternative for separation by implantation of oxygen (SIMOX) to form the silicon-on-insulator (SOI) structure. The chief advantage of SPIMOX is the high throughput and low-cost implanter. The operation regime of implantation for SPIMOX, which uses dc plasma immersion ion implantation (PIII) for the oxygen implantation, has been studied in the phase space of implantation time and chamber pressure during implantation. The phase space is developed for a definite implantation voltage and dose which are dependent on the dimensions of the SOI structure to be fabricated. The effects of dose, implantation voltage, and fractional ionization on the phase space have been discussed. SPIMOX can achieve high throughputs for thin-SOI structure fabrications using high fractional ionization plasmas. The phase space developed for SPIMOX implantation ran also be used for other high-dose dc implantations with PIII which require a peaked implant profile below the surface.
Designing smart health care technology into the home of the future (2003)

This editorial paper presents a vision for intelligent health care in the home of the future, focusing on technologies with the highest potential payoff given targeted government funding over the next ten years. A secure, plug-and-play information framework provides the starting point for identifying technologies that must be developed before smart home-based devices can know their context and assimilate information to make care decisions.
Isolation of endothelial cells from hunan first trimester decidua using immunomagnetic beads (1991)

A technique was developed for the isolation of purified endothelial cells from first trimester decidual tissue, using QB End/40-coated magnetic polystyrene beads (Dynabeads). QB End/40 is an endothelial-specific monoclonal antibody which reacts with the coagulation cascade co-factor, thrombomodulin. Small endothelial cell aggregates were released from first trimester decidua by the sequential use of collagenase and trypsin. This dissociation method yielded 15-20% endothelial cells which were further purified to greater than 90% homogeneity by rosetting with QB End/40-Dynabeads. Cultures of purified decidual endothelial cells provide a useful tool for investigating cell-cell interaction in the first trimester placental bed.
Crossword puzzle of chemical symbols (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrossword puzzle of chemical symbolsCurtis L. Brown Cite this: J. Chem. Educ. 1954, 31, 6, 298Publication Date (Print):June 1, 1954Publication History Received3 August 2009Published online1 June 1954Published inissue 1 June 1954https://doi.org/10.1021/ed031p298RIGHTS & PERMISSIONSArticle Views107Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (889 KB) Get e-Alerts Get e-Alerts
Who are the Britons? (2003)

This chapter contains sections titled: Britons and the Great Celtic Debate Historiography and Methodology
Enhancing Light Blob Detection for Intelligent Headlight Control Using Lane Detection (2013)

In this paper, we propose an enhanced method for detecting light blobs (LBs) for intelligent headlight control (IHC). The main function of the IHC system is to automatically convert high-beam headlights to low beam when vehicles are found in the vicinity. Thus, to implement the IHC, it is necessary to detect preceding or oncoming vehicles. Generally, this process of detecting vehicles is done by detecting LBs in the images. Previous works regarding LB detection can largely be categorized into two approaches by the image type they use: low-exposure (LE) images or autoexposure (AE) images. While they each have their own strengths and weaknesses, the proposed method combines them by integrating the use of the partial region of the AE image confined by the lane detection information and the LE image. Consequently, the proposed method detects headlights at various distances and taillights at close distances using LE images while handling taillights at distant locations by exploiting the confined AE images. This approach enhances the performance of detecting the distant LBs while maintaining low false detections.
Effect of cognitive load in autonomous vehicles on driver performance during transfer of control (2014)

Present study on cognitive workload in driving focuses on reduction of workload for better driving performance. In this paper, we talk about the cognitive load in drivers of autonomous cars and their performance under multiple cognitive loads. Our previous studies have indicated that low to no workload is likely to induce drowsiness in drivers of autonomous vehicles. We hypothesize that there is an optimal cognitive load for a driver during autonomous driving for best performance after transfer of control from autonomous to manual. We propose an experiment to study the cognitive load on the driver of a simulated autonomous car and the effects on manual driving performance. We also describe our use of biometric devices to obtain physiological measures indicative of cognitive workload.
Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. (1994)

The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Recently, activation of the COX enzyme by NO has been described. However, the effects of COX products (PGs) on the NO pathway have not been fully clarified. Thus we determined the effect of COX inhibition and exogenous PGs on NO production and NOS induction in rat mesangial cells. A COX inhibitor, indomethacin, enhanced IL-1 beta-induced steady-state level of the inducible NOS (iNOS) mRNA and nitrite production. The effect of indomethacin was dose dependently reversed by the replacement of endogenous PGE2 with exogenous PGE2, which is the predominant product of the COX pathway in rat mesangial cells. In contrast to PGE2, a stable analog of PGI2, carba prostacyclin, enhanced IL-1 beta-induced iNOS mRNA levels and nitrite production. Forskolin, an activator of the adenylate cyclase, mimicked the effect of carba prostacyclin but not PGE2. These data suggest that (i) endogenous PGE2 downregulates iNOS induction, (ii) this inhibitory effect of PGE2 on iNOS induction is not mediated by activation of adenylate cyclase, and (iii) exogenous PGI2 stimulates COX induction possibly by activation of adenylate cyclase.
Space variant imaging (1995)

Outlines the work of the Interactive Image Based Device for Effective Communication project [IBIDEM] in its aim of developing a video phone useful for lip‐reading by hearing‐impaired people, based on a new generation of space‐variant sensors and using standard telephone lines. The IBIDEM project is constructing a video phone using a camera with a retina‐like sensor, a motorized system for moving the viewpoint of the camera, as well as a display for the transmitted images which will allow high resolution in the area of interest i.e. lips or figures, whilst still maintaining a wide field of view. Experiments have been carried out to evaluate the minimum requirements for the video phone in terms of spatial and temporal resolution and the technical limitations which have to be taken into account in the design of a visual sensor.