gebhart/patrepeval huggingface dataset:
Trimethoprim resistance transposon Tn<i>4003</i> from <i>Staphylococcus aureus</i> encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS<i>257</i> (1989)

Trimethoprim resistance mediated by the Staphylococcus aureus multi-resistance plasmid pSK1 is encoded by a structure with characteristics of a composite transposon which we have designated Tn4003. Nucleotide sequence analysis of Tn4003 revealed it to be 4717 bp in length and to contain three copies of the insertion element IS257 (789-790 bp), the outside two of which are flanked by directly repeated 8-bp target sequences. IS257 has imperfect terminal inverted repeats of 27-28 bp and encodes for a putative transposase with two potential alpha-helix-turn-alpha-helix DNA recognition motifs. IS257 shares sequence similarities with members of the IS15 family of insertion sequences from Gram-negative bacteria and with ISS1 from Streptococcus lactis. The central region of the transposon contains the dfrA gene that specifies the S1 dihydrofolate reductase (DHFR) responsible for trimethoprim resistance. The S1 enzyme shows sequence homology with type I and V trimethoprim-resistant DHFRs from Gram-negative bacteria and with chromosomally encoded DHFRs from Gram-positive and Gram-negative bacteria. 5' to dfrA is a thymidylate synthetase gene, designated thyE.
Guest Editorial: The Question of Making Native Space (2010)

THIS ISSUE OF BC STUDIES honours Cole Harris's book Making Native Space: Colonialism, Resistance, and Reserves in British Columbia (UBC Press, 2002), which has won the 2002 Sir John A. Macdonald Prize (for book in Canadian history) and a Clio Award (for exceptional contributions to regional history) from the Canadian Historical Association, the Royal Canadian Geographical Society's 2003 Massey Medal (for outstanding achievement in Canadian Geography), and the K.D. Shivastava Prize from UBC Press (for excellence in scholarly publishing). This editorial is occasioned by Harris's achievement, and it is my pleasure to briefly comment on both his accomplishments in this book and his wider contribution to the fields of geography and British Columbian studies. Harris has long been one of North America's leading historical geographers and one of the most eloquent and respected methodological voices within the discipline of geography. He is very much the historian's geographer (concerned with how we write historical narratives of geographical change) rather than the geographer's historian (interested in the intellectual development of his field), and is perhaps best known to Canadians for his editorship of the Historical Atlas of Canada, vol. 1: From the beginning to 1800 (1987), and his coeditorship (with Jean Barman) of this journal. But he has also written a number of influential disciplinary essays about the nature and importance of historical perspectives within geography, and has long favoured regional synthesis, the study of rural landscapes, and a
Radiation dose efficiency comparison between differential phase contrast CT and conventional absorption CT (2010)

The differential phase contrast CT method provided higher CNR than conventional absorption CT at equivalent dose levels for most of the materials studied, and so may enable achievement of the same object visibility as conventional absorption CT methods at a lower exposure level.
Controlled thermal coefficient product system and method (2021)

A controlled thermal coefficient product manufacturing system and method is disclosed. The disclosed product relates to the manufacture of metallic material product (MMP) having a thermal expansion coefficient (TEC) in a predetermined range. The disclosed system and method provides for a first material deformation (FMD) of the MMP that comprises at least some of a first material phase (FMP) wherein the FMP comprises martensite randomly oriented and a first thermal expansion coefficient (FTC). In response to the FMD at least some of the FMP is oriented in at least one predetermined orientation. Subsequent to deformation, the MMP comprises a second thermal expansion coefficient (STC) that is within a predetermined range and wherein the thermal expansion of the MMP is in at least one predetermined direction. The MMP may be comprised of a second material phase (SMP) that may or may not transform to the FMP in response to the FMD.
Impacts of I/Q imbalance on QPSK-OFDM-QAM detection (1998)

The impacts of the I/Q imbalance in the quadrature down-converter on the performance of a QPSK-OFDM-QAM system are studied. Either amplitude or phase imbalance introduces inter-channel interference (ICI). In addition to the ICI, there is a cross-talk between in-phase and quadrature channels in each and every sub-carrier when both amplitude and phase imbalances are present. The BER (bit error ratio) performance of QPSK sub-carriers are also calculated to illustrate the impacts of the I/Q imbalance. It is observed that with the amplitude imbalance less than 1 dB and phase imbalance less than 5 degrees, the degradation of BER performance is less than 0.5 dB for a BER>10/sup -6/.
Effect of polysiloxane encapsulation material compositions on emission behaviour and stabilities of perylene dyes (2018)

The replacement of inorganic conversion dyes with their organic counterparts in LED application bears a large potential for the reduction of rare earth elements in these devices. A major challenge of this substitution is the emission and stability of organic dyes, which is more sensitive to the composition of the polymer matrix they are embedded in than inorganic systems. In this study we systematically investigated the influence of the composition and structure of a low refractive index (LRI) polydimethylsiloxane (PDMS) and a high refractive index (HRI) polymethylphenysiloxane (PMPS) based encapsulation material on the optical properties of two different embedded perylene diimide dyes. Both dyes show low solubility in the PDMS matrix, which also fosters the heat- or light-induced degradation of the incorporated dyes. Contrary phenyl containing polysiloxane encapsulation materials enhance dye solubility, improve quantum yields, and promote heat and radiation resistance. Bulky <i>N</i>-aryl substituents at the dye structure decrease the probability of dye-dye interaction and increase the absolute quantum yields additionally. Increased photostability and no leaching was observed when the dye was covalently attached to the polymer matrix. Additionally covalent bonding to and improved solubility of the organic dyes in the polysiloxanes allow for a solvent free processing of such dye-matrix combinations. In conclusion a good matching between the matrix and the dye is crucial for a substitution of inorganic conversion dyes by organic ones in LED devices.
Microbiological, epidemiological and clinical correlates of vaginal colonisation by Mobiluncus species. (1991)

The microbiological and epidemiological correlates of vaginal colonisation by Mobiluncus species were examined among randomly selected women attending a sexually transmitted disease (STD) clinic. Women positive for Trichomonas vaginalis were excluded. Mobiluncus spp. were detected by Gram stained vaginal smear in 21% of 633 STD clinic patients, including 53% of those with and 4% of those without bacterial vaginosis (BV), as diagnosed by clinical criteria. Gardnerella vaginalis and Mycoplasma hominis detected by vaginal culture and Mobiluncus detected by vaginal Gram stain were each independently associated with BV after adjusting by logistic regression for the presence of sexually transmitted disease pathogens, gravidity, parity and number of lifetime sexual partners (p less than 0.001 for each organism). Bacterial vaginosis was negatively correlated with isolation of lactobacilli, yeast and herpes simplex virus. After adjusting for presence or absence of BV, women with Mobiluncus were more likely to harbour G vaginalis (odds ratio 5.6, 95% confidence interval 1.6-19.5), M hominis (OR 3.7, 95% CI 2.0-7.0) and Neisseria gonorrhoeae (OR 2.9, 95% CI 1.4-6.0) and less likely to harbour vaginal yeast (OR 0.4, 95% CI 0.2-1.0); were more likely to be black (OR 2.7, 95% CI 1.5-4.6), and to have been pregnant (OR 1.8, 95% CI 1.1-3.1); but after the adjustment for BV, vaginal colonisation by Mobiluncus was not associated with symptoms of odour, abdominal pain, menstrual irregularities, or with adnexal tenderness. In summary, Mobiluncus, Gardnerella vaginalis and Mycoplasma hominis were independently associated with a clinical diagnosis of bacterial vaginosis, and Mobiluncus was further associated with the presence of BV-associated microorganisms (M hominis and G vaginalis), N gonorrhoeae, black race, and gravidity.
MicroRNA-29a Promotes Pancreatic Cancer Growth by Inhibiting Tristetraprolin (2015)

Our results suggest that miR-29a acts as an oncogene by down regulating TTP and provide the basis for further studies exploring the potential of miR-29a and TTP as biomarkers and targets for the treatment of pancreatic cancer.
A robust background subtraction method for changing background (2002)

Background subtraction is a useful and effective method for detecting moving objects in video images. Since this method assumes that image variations are caused only by moving objects (i.e., the background scene is assumed to be stationary), however, its applicability is limited. In this paper, we propose a background subtraction method that robustly handles various changes in the background. The method learns the chronological changes in the observed scene's background in terms of distributions of image vectors. The method operates the subtraction by evaluating the Mahalanobis distances between the averages of such image vectors and newly observed image vectors. The method we propose herein expresses actual changes in the background using a multi-dimensional image vector space. This enables the method to detect objects with the correct sensitivity. We also introduce an eigenspace to reduce the computational cost. We describe herein how approximate Mahalanobis distances are obtained in this eigenspace. In our experiments, we confirmed the proposed method's effectiveness for real world scenes.
The Mechanism of Interaction of Sodium Dodecyl Sulfate with Elastic Fibers (1995)

Sodium dodecyl sulfate (SDS), an anionic hydrophobic ligand, is known to alter the mechanical properties of elastic fibers. In order to analyze the mechanism of the alteration, two forms of fibrous elastins, "solid" and "powder" elastins, which consisted of fascicular elastic fibers and single or oligomeric elastic fibers, respectively, were prepared from bovine aorta, and the interactions of SDS with these elastins in the presence and absence of 0.15 M NaCl were studied. The solid elastin was able to retain 1.2- to 1.4-fold larger amounts of SDS than the powder elastin under both conditions, and both elastins retained 1.2-fold or larger amounts of SDS in the presence of NaCl than in its absence. Whereas both elastins released the retained SDS gradually on repeated washing with an SDS-free buffer, the release rates from the solid elastin, especially the rate in the presence of NaCl, were much smaller than those from the powder elastin, and the solid elastin retained approximately 40% of the bound SDS under conditions where the powder elastin lost most of its SDS. The SDS-binding capacities of both elastins were significantly lower than those of soluble kappa-elastin and serum albumin, which bound SDS homogeneously on the polypeptide chains. When the washed SDS-bound solid elastin was incubated with methylene blue and examined under a microscope, most of the methylene blue-SDS complex was located at the interfiber spaces of the elastic fibers. These results suggest that SDS alters the mechanical properties of elastic fibers by binding to the interfiber spaces and surfaces of the fibers rather than by binding to the internal polypeptide chains.
Milrinone (1995)

Administration of milrinone in neonates with low cardiac output after cardiac surgery lowers filling pressures, systemic and pulmonary arterial pressures, and systemic and pulmonary vascular resistances, while improving cardiac index. Milrinone increases heart rate without altering myocardial oxygen consumption. While milrinone appears to be effective and safe during short-term use, the relative distribution of inotropic and vasodilatory properties of milrinone remains to be elucidated.
The hypnotic effects of melatonin treatment on diurnal sleep in humans (1999)

This study investigated the hypnotic effects of 10 mg melatonin and placebo, which were administered at 10.00 h, according to a single-blind crossover design, on an 8-h diurnal sleep from 11.00 to 19.00 h, following a full night of sleep. The subjects were six healthy male students, each of whom underwent polysomnography and rectal temperature monitoring. Melatonin treatment significantly increased total sleep time in diurnal sleep (403.2+/-SD 72.8 min and 258.5+/-118.3 min, P<0.001). As to changes in rectal temperature during diurnal sleep, however, there were no significant differences between the melatonin and placebo conditions. Thus, these results indicated that melatonin administered at 10.00 h had direct hypnotic effects on diurnal sleep.
Dynamics of mobilization and homing of endothelial progenitor cells after acute renal ischemia: modulation by ischemic preconditioning (2006)

Endothelial progenitor cells (EPCs) have been shown to participate in tissue repair under diverse physiological and pathological conditions. It is unknown whether EPCs are mobilized in response to acute renal injury. The aim of this study was to characterize EPC mobilization and homing in the course of acute renal ischemia. Mice were subjected to unilateral renal artery clamping (UC) for 25 min. At 10 min, 3, 6, 24 h, and 7 days after UC, the pool of circulating and splenic CD34+/Flk-1+ cells within the monocytic population was detected by flow cytometry. For ischemic preconditioning (IPC), the first UC was performed 7 days before the repeated ischemic episode. For EPC detection in the kidney, cryosections were stained for c-Kit+/Tie-2+ cells. The number of circulating EPCs was not significantly affected at any time after UC compared with sham-operated or control mice. IPC did not significantly change the circulating pool of EPCs. Splenectomy performed before UC resulted in a surge of circulating EPCs. Accordingly, splenic EPCs were significantly increased after UC at 3 and 6 h, but not at later times. EPC homing to the spleen was absent in IPC animals. Immunohistochemical analysis of the kidneys showed a sixfold increase in the number of c-Kit+/Tie-2+ cells localized in the medullopapillary region in mice by day 7 after ischemia. Enriched population of c-Kit+/Tie-2+ cells from the medullopapillary parenchyma of Tie-2green fluorescent protein chimeric mice subjected to IPC was isolated and transplanted to wild-type mice with acute renal ischemia. This procedure resulted in the improvement of renal function in recipients. In conclusion, 1) renal ischemia rapidly (within 3-6 h) mobilizes EPCs, which transiently home to the spleen, acting as a temporary reservoir of mobilized EPCs; 2) the late phase of IPC is associated with the mobilization of the splenic pool and accumulation of EPCs in the renal medullopapillary region; and 3) transplantation of EPC-enriched cells from the medullopapillary parenchyma afforded partial renoprotection after renal ischemia, suggesting the role of the recruited EPCs in the functional rescue.
The Effect of TRALE (Technology-Rich Authentic Learning Environments) on Young Urban Learners� Intentionality in Writing (2010)

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A digitally-corrected 20b delta-sigma modulator (2002)

Transducers such as photodiodes produce signal currents in the 1 pA to 1 /spl mu/A range. To achieve a six-decade dynamic range, thermal noise currents at the system input must be minimized. The authors show that including the transimpedance photodiode amplifier in a delta-sigma modulated loop with digitally-corrected trilevel quantizers/DACs leads to lower thermal noise. The characteristics of the modulator are summarized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Minimally Invasive Atrial Fibrillation Ablation Combined with a New Technique for Thoracoscopic Stapling of the Left Atrial Appendage: Case Report (2004)

Thoracoscopic epicardial microwave ablation of AF is a technically feasible procedure with minimal risk. The computer deployment and motion controlled stapling system that we used in this case has the potential to become a safe and reliable alternative to conventional stapling instruments.
Jatrophone, a novel macrocyclic diterpenoid tumor inhibitor from Jatropha gossypiifolia (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTJatrophone, a novel macrocyclic diterpenoid tumor inhibitor from Jatropha gossypiifoliaS. Morris Kupchan, Carl W. Sigel, M. J. Matz, Jose A. Saenz Renauld, Ralph C. Haltiwanger, and Robert F. BryanCite this: J. Am. Chem. Soc. 1970, 92, 14, 4476–4477Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://pubs.acs.org/doi/10.1021/ja00717a066https://doi.org/10.1021/ja00717a066research-articleACS PublicationsRequest reuse permissionsArticle Views435Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential light scattering photometer for rapid analysis of single particles in flow (1980)

A differential light scattering photometer has been developed for rapid size analysis of single particles in flow. A fluid stream carrying individual particles in single file intersects a focused laser beam at the primary focal point of an annular strip of an ellipsoidal reflector situated in a scattering chamber. The light scattered from polar angles theta = 2.5-177.5 degrees at azimuthal angles phi = 0 and 180 degrees , spanning a circle of 355 degrees , is reflected onto a circular array of 60 photodiodes. The signal processing electronics and computer storage can accept 32 signals/particle at rates up to 1000 particles/sec. Photometer performance is tested by comparing measured responses from individual spherical particles with angular scattering patterns calculated for the particular detector geometry. These patterns exhibit the required symmetry in the two half scattering planes. Response measurements for eight samples with particle diameters of 1.1, 2.7, 5.0, 7.9, 10.0, 12.5, 15.6, and 19.5 microm are consistent with calculated size-response curves. The composition of a mixture of five components with particle diameters of 1.1, 5.0, 10.0, 15.6, and 19.5 Am is determined from an analysis of light scattering measurements at various forward-scattering angles.
Convergence properties of a pulsed neural network (1990)

A neural network based on pulse-width-modulated signals is described. Simulation results for the pulsed equivalent of a two-neuron Hopfield network show that proper convergence is achieved without heavy low-pass filtering. This suggests that temporal information may be of little importance in a certain class of pulsed neural network architectures
Oxidation of 1‐<i>O</i>‐(alk‐1‐enyl)‐2,3‐di‐<i>O</i>‐acylglycerols: Models for plasmalogen oxidation (1988)

Alk-1-enyl diacyl glycerides, model compounds for plasmalogen lipids, were synthesized for use as substrates in oxidation studies. The neutral plasmalogen glycerides prepared included 1-O-(hexadec-1-enyl)-2,3-di-O-stearoylglycerol (4a) and 1-O-(hexadec-1-enyl)-2-O-linoleoyl-3-O-stearoylglycerol (4b). Oxidative disappearance of these glycerides was followed directly by high performance liquid chromatography (HPLC). The extent of oxidation of the side chains of these glycerides, i.e. the alkenyl ether and fatty acyl functions, was monitored by conversion of the side chains to dimethylacetal and methyl ester by methanolysis, followed by subsequent gas chromatography (GC) of the methanolysis products. Both analytical approaches show that the alkenyl ether function of neat 4a oxidizes more slowly than neat ethyl linoleate. However, the rate of alkenyl ether loss from 4a is accelerated in the presence of added ethyl linoleate. Moreover, when the linoleoyl group is incorporated into the 2-position of the alkenyl glyceride, as in 4b, the rate of loss of the alkenyl group was shown to be similar to the rate of loss of the linoleoyl group. These results suggest that oxidation of plasmalogen glycerides should not be ignored as a factor that contributes to the oxidative instability of animal tissue.