gebhart/patrepeval huggingface dataset:
CPCE: a kernel for building flexible collaborative process-centered environments (2002)

CPCE Project aims at developing a process-centered environment kernel for supporting 'focused collaborative work'. Focused collaboration requires a high level of adaptability and dynamic flexibility. The paper stresses the importance of both process model and enactment mechanisms evolution. The main design decisions, concepts, and techniques used to satisfy these requirements are discussed: object-oriented process modeling, reflection, open implementation and meta object protocol, meta process modeling and support. A prototype of dedicated environment, built by customizing the kernel, and devoted to the collaborative review/inspection of software products, illustrates the proposal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Beta-very low density lipoprotein pretreatment of endothelial monolayers increases monocyte adhesion. (1989)

Treatment of rabbit aortic endothelial cells or human umbilical vein cells for as little as 1 day with 25 micrograms/ml of beta-migrating very low density lipoprotein (beta-VLDL), but not low density lipoprotein (LDL), caused an increased binding of human peripheral blood monocytes to the endothelium. This increase was maximal by 24 hours but was not significant at 4 hours of pre-incubation with beta-VLDL. Neutrophil binding was not significantly stimulated by beta-VLDL treatment of endothelial cells, while endotoxin (LPS) treatment of endothelial cells stimulated both neutrophil and monocyte binding. Antibody to leukocyte function-associated-antigen-1 and to Mo2 inhibited binding to both beta-VLDL-stimulated and LPS-stimulated cells by 25%. The fact that both rabbit and human cells were stimulated by beta-VLDL to bind human monocytes suggests that some mechanisms regulating binding are conserved between species. These studies suggest that beta-VLDL acts like a chronic inflammatory mediator to cause a sustained increase in binding of monocytes to the endothelium.
Characterization of the Linkage between the Type III Capsular Polysaccharide and the Bacterial Cell Wall of Group BStreptococcus (2000)

The capsular polysaccharide of group B Streptococcus is a key virulence factor and an important target for protective immune responses. Until now, the nature of the attachment between the capsular polysaccharide and the bacterial cell has been poorly defined. We isolated insoluble cell wall fragments from lysates of type III group B Streptococcus and showed that the complexes contained both capsular polysaccharide and group B carbohydrate covalently bound to peptidoglycan. Treatment with the endo-N-acetylmuramidase mutanolysin released soluble complexes of capsular polysaccharide linked to group B carbohydrate by peptidoglycan fragments. Capsular polysaccharide could be enzymatically cleaved from group B carbohydrate by treatment of the soluble complexes with beta-N-acetylglucosaminidase, which catalyzes hydrolysis of the beta-D-GlcNAc(1-->4)beta-D-MurNAc subunit produced by mutanolysin digestion of peptidoglycan. Evidence from gas chromatography/mass spectrometry and (31)P NMR analysis of the separated polysaccharides supports a model of the group B Streptococcus cell surface in which the group B carbohydrate and the capsular polysaccharide are independently linked to the glycan backbone of cell wall peptidoglycan; group B carbohydrate is linked to N-acetylmuramic acid, and capsular polysaccharide is linked via a phosphodiester bond and an oligosaccharide linker to N-acetylglucosamine.
An Architecture for the Optimum Delivery of Data to a Mobile Client "SMOOTHIE" (2002)

Abstract-- The advent of 2.5G and 3G mobile phone systems will allow a much greater bandwidth capacity for mobile devices than current systems. However, the bandwidth available for mobile systems is constrained by the limited air-interface bandwidth allocated to telecommunications companies operating these systems. As a result, bandwidth over a mobile system&apos;s air interface will always be more expensive than fixed line networks. Two important issues result. Firstly, operators will need to smoothen out the peaks of demand on the networks. This can be achieved by pre-fetching data at off-peak times that will be requested by a user during a peak period. Similarly, low priority requests that are initiated during peak periods can be delayed until a later time when the system is under a lighter load. Secondly, the operators will need to provide a quality of service assurance to customers who are prepared to pay premium rates for important data transfers. An architecture of a software system that resides on the client
Fabrication and Characterization of Micro Dent Arrays by Laser Shock Peening on Ti-6Al-4V Surfaces (2009)

Surface micro dents may act as lubricant reservoirs to reduce friction and wear in sliding and rolling contact applications. Surface patterning has become a valuable technique for fabricating micro dents. Alternative methods such as micromachining present obvious limitations in comparison with laser shock peening (LSP). In this paper, the use of LSP along with an automatic X-Y table proves to be an attractive and reliable method for producing micro dent arrays with enhanced surface integrity and free of cracks. Surface topography, residual stress, and microhardness of the fabricated micro dent arrays on polished Ti-6A1-4V have been characterized. It has shown that LSP is capable of efficiently fabricating mass micro dent arrays with controllable size. The center area of the peened dents has highest hardness. In addition, high compressive residual stress can also be created.
Dual effects of arsenic trioxide (As<sub>2</sub>O<sub>3</sub>) on non‐acute promyelocytic leukaemia myeloid cell lines: induction of apoptosis and inhibition of proliferation (2002)

Clinical efficacy of As2O3 has been shown in patients with relapsed acute promyelocytic leukaemia (APL). There is evidence that the effects of As2O3 are not restricted to events specific for APL. As2O3 might target mechanisms involved in the pathogenesis of other malignancies. We assessed susceptibility to induction of apoptosis by As2O3 and cytostatics in 22 myeloid and non-myeloid malignant cell lines. As2O3 was used in concentrations of 0.01-10 micromol/l. Cell lines displayed different kinetics of response and different sensitivity to As2O3. The minimum concentration of As2O3 for induction of apoptosis was 0.1 micromol/l. High concentrations of As2O3 (5 micromol/l) induced apoptosis in a large proportion of cells in all cell lines tested. Low (1 micromol/l As2O3) concentrations induced apoptosis in NB-4, HL-60, U-937, CEM, HL-60, KG-1a, PBL-985, ML-2 and MV-4-11, but not in HEL, K-562, KG-1 and Jurkat up to 35 d of incubation. However, the non-apoptotic population of 1 micromol/l As2O3-treated HEL, K-562, K-562 (0.02), K-562(0.1) and Jurkat showed reduced proliferation. CEM as well as its' multidrug-resistant derivatives were sensitive to 1 micromol/l As2O3. In summary, these data demonstrate that As2O3-induced apoptosis is not restricted to cell lines with t(15;17). Apoptosis was induced in vitro by As2O3 concentrations that are achievable in vivo after infusion of well-tolerated As2O3 doses. Thus, As2O3 might be a suitable therapeutic agent for malignancies other than APL provided the adequate dose and duration of As2O3 treatment are used.
Surface cleaning of metals in air with a one atmosphere uniform glow discharge plasma (1995)

Summary form only given, as follows. We report the use of active species generated in a one atmosphere uniform glow discharge plasma reactor with a parallel-plate configuration to clean the surface of as-received metal samples from the machine shop floor. The unmagnetized air plasma in this reactor had the following characteristic operating and plasma parameters: RF frequency, 1-4 kHz; RMS electric field, 9 kV/cm; RMS voltage, 4 kV; plasma number density, 10/sup 10//cm/sup 3/; and plasma power density of tens of milliwatts/cm/sup 3/. The experimental arrangement used to expose our 7 by 10 cm metal samples. The lower parallel-plate electrode is a flat copper plate, covered by a pyrex sheet. The upper electrode is formed by the bare metal sample plate, with the side to be cleaned facing the plasma. To assure plasma uniformity between the electrodes, it was helpful to direct a flow of air on the edges of the plasma volume. The cleanliness of the metal samples was determined with the standard sessile water drop test. In their as-received condition, the metal samples yielded a contact angle of 90/spl deg/ or more, indicating a non-wettable surface, presumably because of (adherent layers of hydrocarbon machine oils. After from 3 to 10 minutes of plasma exposure, however, the water-drop test yielded a contact angle well below 10/spl deg/, a very wettable surface. The metal surfaces would remain wettable for hours, until the surfaces became re-contaminated by exposure to the atmosphere.
Conductivity Optimization of Tysonite-type La<sub>1–<i>x</i></sub>Ba<sub><i>x</i></sub>F<sub>3–<i>x</i></sub> Solid Electrolytes for Advanced Fluoride Ion Battery (2017)

Use of lithium ion batteries is currently the method of choice when it comes to local stationary storage of electrical energy. In the search for an alternative system, fluoride ion batteries (FIBs) emerge as a candidate due to their high theoretical capacity, and no lithium is needed for its operation. To improve the cycling performance and lower the working temperature of a solid-state battery, one of the critical components is the electrolyte, which needs advanced performance. This paper aims at developing an electrolyte with enhanced ionic conductivity for fluoride ions, to be used in a FIB. Tysonite La<sub>1-x</sub>Ba<sub>x</sub>F<sub>3-x</sub> (0 ≤ x ≤ 0.15) solid solutions were synthesized by a facile wet chemical method, and its ionic conductivity was analyzed using electrochemical impedance spectroscopy. A composition study shows that the conductivity reaches a maximum of 1.26 × 10<sup>-4</sup> S·cm<sup>-1</sup> at 60 °C for the La<sub>0.95</sub>Ba<sub>0.05</sub>F<sub>2.95</sub> pellet sintered at 800 °C for 20 h, which is 1 order of magnitude higher than that for the as-prepared pellet and 2 times higher than the conductivity of sintered ball-milled batches. The reason for this dramatic increment is the more efficient decrement of grain boundary resistance upon sintering. Morphological, chemical, and structural characterizations of solid electrolytes were studied by X-ray diffraction, scanning electron microscopy , energy dispersive X-ray spectroscopy, physisorption by the Brunauer-Emmett-Teller method, and transmission electron microscopy. Electrochemical testing was carried out for the FIB cell using La<sub>0.95</sub>Ba<sub>0.05</sub>F<sub>2.95</sub> as electrolyte due to its highest conductivity among the compositions, Ce as anode, and BiF<sub>3</sub> as a cathode. The cycling performance was found to be considerably improved when compared to our earlier work, which used the ball-milled electrolyte.
Human Tumor Antigens Inducing in vivo Delayed Hypersensitivity and in vitro Mitogenic Activity (1983)

Significant immunogenic properties were observed with an antigen extracted from tumor-liberated particles (TLP). Several different tumors were used to obtain antigens by such cell analysis and purification procedures as: gel filtration on Sephadex G-100, ion-exchange chromatography, affinity chromatography, and gel filtration on Sephadex G-200. The molecular weight determined on SDS-PAGE was about 214,000 daltons. In vivo, TLP yields delayed hypersensitivity reactions both in autologous and homologous hosts. TLP does not seem to have any nonspecific mitogenic activity, but it does have specific mitogenic activity, since lymphocyte blastogenesis (TLP-induced in presensitized patients) could mean its ability when intradermally inoculated to sensitize a lymphocytic clone.
Behaviour of Protein C Inhibitor in Intravascular Coagulation and Liver Disease (1984)

Summary We measured levels of protein C inhibitor in patients with disseminated intravascular coagulation (DIC) and liver disease using a functional assay. Levels in 24 normal subjects averaged 93% of the amount in normal pooled plasma, giving a normal range of 65 to 121%. Levels were below normal in 8 of 17 patients with DIC, in 4 of 19 patients with liver cirrhosis, and in 3 patients with acute hepatic necrosis. Levels were normal or elevated in 9 of 10 patients with cirrhosis and accelerated fibrinolysis, and in 6 patients receiving warfarin. We conclude that protein C inhibitor may be involved in regulation of protein C activity during pathologic activation of the hemostatic system (DIC). Decreased protein C inhibitor does not appear to contribute to the pathogenesis of accelerated fibrinolysis in liver disease. The liver may be the site of synthesis of protein C inhibitor.
Content-based image classification using quasi-Gabor filters (2004)

This paper proposed an approach of online content filtering system, which can filter unexpected content from Internet, support searching, detecting, recognizing images, video and multimedia data. The approach consists of three parts: first is texture feature extraction with quasi-Gabor filters. These filters are constructed in different directions and sizes in frequency domain of images. This avoids convolution and multiplication with images spatially. Second, the extracted features are sent to Kohonon neural networks to perform decreasing dimension. The outputs of Kohonon network are then fed to a neural network classifier to get the final classification result. The proposed approach has been applied in our content monitoring system, which can filter unexpected images and alarm by pre-defined requirement.
Privacy preserving document indexing infrastructure for a distributed environment (2008)

To carry out work assignments, small groups distributed within a larger enterprise or collaborative community often need to share documents among themselves while shielding those documents from others' eyes. In this situation, users need an indexing facility that can quickly locate relevant documents that they are allowed to access, without (1) leaking information about the remaining documents, (2) imposing a large management burden as users, groups, and documents evolve, or (3) requiring users to agree on a central completely trusted authority. In order to achieve this aim user access levels and access control have to be reflected in the index structures and/or retrieval algorithms as well as in ranking the search results. My Ph.D. work focuses on building up an indexing infrastructure which supports confidential indexing, sharing and retrieval of unstructured information which is spread over a number of distributed access-controlled collections. In order to allow for effective and efficient indexing and retrieval in these settings, it considers aspects of confidentiality preservation within an outsourced inverted index, a DHT index structure in P2P networks as well as confidential top-k information retrieval.
Comparative effect of Mycobacterium bovis- and neuraminidase-treated tumor cells on the growth of established methylcholanthrene fibrosarcomas in syngeneic mice. (1972)

The total regression of firmly established methylcholanthrene fibrosarcomas can be induced in syngeneic mice by inoculation of living tumor cells treated in vitro with Vibrio cholerae neuraminidase plus mitomycin C. Multiple injections of such vaccines are more effective than a single inoculation. By comparison, Mycobacterium bovis injected either directly into the tumor nodule or s.c. in sites distant from the tumor will induce a reduction in growth rate but will rarely induce the total disappearance of the tumor. The use of neuraminidase-treated tumor vaccines is far more efficient than the use of M. bovis in inducing the regression of methylcholanthrene fibrosarcomas. The mechanism of action probably rests with the increased immunogenicity of tumor cells after digestion of their coats with V. cholerae neuraminidase.
Lithium: Measurement of Young's Modulus and Yield Strength (2002)

The Lithium Collection Lens is used for anti-proton collection. In analyzing the structural behavior during operation, various material properties of lithium are often needed. properties such as density, coefficient of thermal expansion, thermal conductivity, specific heat, compressability, etc.; are well known. However, to the authors knowledge there is only one published source for Young's Modulus. This paper reviews the results from the testing of Young's Modulus and the yield strength of lithium at room temperature.
Empirical evaluation of the CRAY-T3D (1995)

Most recent MPP systems employ a fast microprocessor surrounded by a shell of communication and synchronization logic. The CRAY-T3D provides an elaborate shell to support global-memory access, prefetch, atomic operations, barriers, and block transfers. We provide a detailed empirical performance characterization of these primitives using micro-benchmarks and evaluate their utility in compiling for a parallel language. We have found that the raw performance of the machine is quite impressive and the most effective forms of communication are prefetch and write. Other shell provisions, such as the bulk transfer engine and the external Annex register set, are cumbersome and of little use. By evaluating the system in the context of a language implementation, we shed light on important trade-offs and pitfalls in the machine architecture.
Sarcoplasmic–endoplasmic–reticulum Ca<sup>2+</sup>‐ATPase and calsequestrin are overexpressed in spared intrinsic laryngeal muscles of dystrophin‐deficient <i>mdx</i> mice (2009)

In the mdx mouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated with increased calcium levels and skeletal muscle myonecrosis. The intrinsic laryngeal muscles (ILM) are protected and do not undergo myonecrosis. We investigated whether this protection is related to an increased expression of calcium-binding proteins, which may protect against the elevated calcium levels seen in dystrophic fibers. The expression of sarcoplasmic-endoplasmic-reticulum Ca(2+)-ATPase and calsequestrin was examined in ILM and in nonspared limb muscles of control and mdx mice using immunofluorescence and immunoblotting. Dystrophic ILM presented a significant increase in the proteins studied when compared to controls. The increase of Ca(2+)-handling proteins in dystrophic ILM may permit better maintenance of calcium homeostasis, with the consequent absence of myonecrosis. The results further support the concept that abnormal Ca(2+)-handling is involved in dystrophinopathies. Muscle Nerve, 2009.
Use of glycosylated dendrimer macromolecules to fluorescently monitor glucose concentration (2007)

A minimally invasive biosensor is undergoing development to detect physiological concentrations of glucose within interstitial fluid. The sensor is based on a chemical assay consisting of Alexa Fluor 647 labeled concanavalin A lectin and dendrimer macromolecules functionalized to contain peripheral glucose moieties. The two components form large cross-linked particles that result in loss of fluorescent emission through shielding of interior fluorophores. As glucose is introduced into the assay, it competes with the glycodendrimers for binding to concanavalin A to disrupt the cross-linked complex and produce a reversible change in fluorescence intensity that is dependent on glucose concentration. Chemical analogs of the original glycodendrimer have been created and analyzed with the purpose of creating more stable and consistent dendrimers in order to maximize the response of the assay so that its signal can be better detected through dermal tissue and provide a better understanding of the sensor binding mechanics.
Determinacy in static analysis for jQuery (2014)

Static analysis for JavaScript can potentially help programmers find errors early during development. Although much progress has been made on analysis techniques, a major obstacle is the prevalence of libraries, in particular jQuery, which apply programming patterns that have detrimental consequences on the analysis precision and performance. Previous work on dynamic determinacy analysis has demonstrated how information about program expressions that always resolve to a fixed value in some call context may lead to significant scalability improvements of static analysis for such code. We present a static dataflow analysis for JavaScript that infers and exploits determinacy information on-the-fly, to enable analysis of some of the most complex parts of jQuery. The analysis combines selective context and path sensitivity, constant propagation, and branch pruning, based on a systematic investigation of the main causes of analysis imprecision when using a more basic analysis.
Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery (2012)

We report the synthesis and characterization of a series of ionizable lysine-based lipids (ILL), novel lipids containing a lysine headgroup linked to a long-chain dialkylamine through an amide linkage at the lysine α-amine. These ILLs contain two ionizable amines and a carboxylate, and exhibit pH-dependent lipid ionization that varies with lipid structure. The synthetic scheme employed allows for the simple, orthogonal manipulation of lipids. This provides a method for the development of a compositionally diverse library with varying ionizable headgroups, tail structures, and linker regions. A focused library of four ILLs was synthesized to determine the impact of hydrophobic fluidity, lipid net charge, and lipid pK(a) on the biophysical and siRNA transfection characteristics of this new class of lipids. We found that manipulation of lipid structure impacts the protonation behavior, electrostatically driven membrane disruption, and ability to promote siRNA mediated knockdown in vitro. ILL-siRNA liposomal formulations were tested in a murine Factor VII model; however, no significant siRNA-mediated knockdown was observed. These results indicate that ILL may be useful in vitro transfection reagents, but further optimization of this new class of lipids is required to develop an effective in vivo siRNA delivery system.
Disaster Recovery/High Availability Failover Plan for Vail Resorts InfoGenesis Food and Beverage Database Management System (2009)

This paper discusses the implementation of a high-availability/disaster recovery plan for Vail Resorts' Infogenesis food and beverage database management systems. The discussion includes a description of the Information Technology (IT) and Infogenesis architecture at Vail Resorts. Additionally, the reasons to have a plan as well as what constitutes a DR plan are also dealt with. Different high-availability/disaster recovery technologies that are currently available are addressed. Finally, the paper examines the decisions made and the procedures chosen to maintain high availability and disaster recovery with minimal downtime given the available resources for the Vail Resorts' Infogenesis food and beverage database management systems.
Complete primary structure of a calcium‐dependent serine proteinase capable of degrading extracellular matrix proteins (1989)

A novel calcium-dependent serine proteinase (CASP) secreted from malignant hamster embryo fibroblast Ni 12C2 degrades extracellular matrix proteins. A complementary DNA encoding CASP has been isolated with the use of oligonucleotide probes synthesized based on partial amino acid sequences of CASP. The complete amino acid sequences of CASP revealed that it has a active site at the C-terminal side. Glu rich and proEGF homologous sites are found at the N-terminal site suggesting that it is structurally similar to blood coagulation factors such as IX, X and an anticoagulation factor, protein C.