gebhart/patrepeval huggingface dataset:
Oxypropylation of Lignins and Preparation of Rigid Polyurethane Foams from the Ensuing Polyols (2005)

Abstract Summary: Different lignins were converted into polyols by a chain extension reaction with propylene oxide ( PO ). Thus, soda lignin from Alfa ( Stipa tenacissima ) ( SL ), organosolv lignin from hardwoods ( OL ), kraft lignin ( KL ) from softwood and oxidized organosolv lignin ( OOL ) were oxypropylated in a batch reactor at 180 °C in the presence of KOH as catalyst. The ensuing polyols were characterized by FTIR and 1 H NMR spectroscopy, which showed that they had incorporated poly(propylene oxide) grafts into their structure. Their viscosity varied from 5 mPa · s to infinity, depending on the Lignin / PO ratio and their hydroxy index was in the range of 100–200, which made them suitable for rigid polyurethane foam (RPU) formulations. The RPUs thus obtained had a T g of ca. 60 °C and a thermal conductivity of ≈20 mW/m · K before ageing and ≈25 mW/m · K after accelerated ageing for 10 d at 70 °C. The analyses of the gases inside the cells showed that these were mostly closed, since the partial pressure did not decrease significantly with ageing. Photograph of polyurethane foam made from OLOP . magnified image Photograph of polyurethane foam made from OLOP .
Toward automatic robot programming: learning human skill from visual data (2000)

We propose a novel approach to program a robot by demonstrating the task multiple number of times in front of a binocular vision system. We track artificially-induced features appearing in the image plane due to nonimpedimental color stickers attached at different fingertips and wrist joint, in a simultaneous feature detection and tracking framework. A Kalman filter does the tracking by recursively predicting the tentative feature location and a higher order statistics (HOS)-based data clustering algorithm extracts the feature. A fast and efficient algorithm for the vision system thus developed processes a binocular video sequence to obtain the trajectories and the orientation information of the end effector from the images of a human hand. The concept of trajectory bundle is introduced to avoid singularities and to obtain an optimal path.
Dentinal Sensation and Hypersensitivity: A Review of Mechanisms and Treatment Alternatives (1985)

Dentinal hypersensitivity has long been a dilemma of both dentists and patients. With teeth being maintained longer, there has been an increased demand placed upon the dentist to manage the sensitivity of cervically exposed dentin. There has been much written on this subject. The purpose of this review is to summarize the current concepts thought to be responsible in dentinal sensation, and to review and critique the various treatment modalities for dentinal hypersensitivity.
Synthesis and Evaluation of Acyl‐Chain‐ and Galactose‐6′′‐Modified Analogues of α‐GalCer for NKT Cell Activation (2012)

α-GalCer is an immunostimulating glycolipid that binds to CD1d molecules and activates invariant natural killer T (iNKT) cells. Here we report a scaled-up synthesis of α-GalCer analogues with modifications in the acyl side chain and/or at the galactose 6''-position, together with their evaluation in vitro and in vivo. Analogues containing 11-phenylundecanoyl acyl side chains with aromatic substitutions (14, 16-21) and Gal-6''-phenylacetamide-substituted α-GalCer analogues bearing p-nitro- (32), p-tert-butyl (34), or o-, m-, or p-methyl groups (40-42) displayed higher IFN-γ/IL-4 secretion ratios than α-GalCer in vitro. In mice, compound 16, with an 11-(3,4-difluorophenyl)undecanoyl acyl chain, induced significant proliferation of NK and DC cells, which should be beneficial in killing tumors and priming the immune response. These new glycolipids might prove useful as adjuvants or anticancer agents.
Syntheses of Chiral 1,8‐Cineole Metabolites and Determination of Their Enantiomeric Composition in Human Urine After Ingestion of 1,8‐Cineole‐Containing Capsules (2012)

Abstract The chiral metabolites in human urine were investigated after ingestion of a 1,8‐cineole (eucalyptol)‐containing entero‐coated capsule (Soledum). For identification of the various enantiomers the enantiomerically pure (−/+)‐α2‐hydroxy‐1,8‐cineole, (−/+)‐β2‐hydroxy‐1,8‐cineole, (−/+)‐9‐hydroxy‐1,8‐cineole, and (−/+)‐2‐oxo‐1,8‐cineole were prepared. To achieve this aim, after acetylation of the synthesized racemic 2‐ and 9‐hydroxy‐1,8‐cineoles, pig liver esterase‐ or yeast‐mediated hydrolysis provided the (−)‐alcohols with their antipodal (+)‐acetates with enantiomeric excess of 33–100 %. Dess–Martin periodinane oxidation of the alcohol (+)‐α2‐hydroxy‐1,8‐cineole, obtained by hydrolysis of the resolved acetate, provided the corresponding (+)‐2‐oxo‐1,8‐cineole, meanwhile the oxidation of (−)‐α2‐hydroxy‐1,8‐cineole gave (−)‐2‐oxo‐1,8‐cineole. Using these standards seven metabolites (+/−)‐α2‐hydroxy‐1,8‐cineole, (+/−)‐β2‐hydroxy‐1,8‐cineole, (+/−)‐α3‐hydroxycineole, (+/−)‐3‐oxo‐1,8‐cineole, 4‐hydroxy‐1,8‐cineole, 7‐hydroxy‐1,8‐cineole, and (+/−)‐9‐hydroxy‐1,8‐cineole, all liberated from their glucuronides, were identified in urine by GC‐MS on a chiral stationary phase after consumption of 100 mg of 1,8‐cineole. Metabolite screening using 2 H 3 ‐1,8‐cineol as the internal standard revealed (+/−)‐α2‐hydroxy‐1,8‐cineole as the predominant metabolite followed by (+/−)‐9‐hydroxy‐1,8‐cineole. Furthermore, the results showed that one enantiomer is always formed preferentially.
Pharmacological Uncoupling of Activation Induced Increases in CBF and CMRO<sub>2</sub> (2009)

Neurovascular coupling provides the basis for many functional neuroimaging techniques. Nitric oxide (NO), adenosine, cyclooxygenase, CYP450 epoxygenase, and potassium are involved in dilating arterioles during neuronal activation. We combined inhibition of NO synthase, cyclooxygenase, adenosine receptors, CYP450 epoxygenase, and inward rectifier potassium (Kir) channels to test whether these pathways could explain the blood flow response to neuronal activation. Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO(2)) of the somatosensory cortex were measured during forepaw stimulation in 24 rats using a laser Doppler/spectroscopy probe through a cranial window. Combined inhibition reduced CBF responses by two-thirds, somatosensory evoked potentials and activation-induced CMRO(2) increases remained unchanged, and deoxy-hemoglobin (deoxy-Hb) response was abrogated. This shows that in the rat somatosensory cortex, one-third of the physiological blood flow increase is sufficient to prevent microcirculatory increase of deoxy-Hb concentration during neuronal activity. The large physiological CBF response is not necessary to support small changes in CMRO(2). We speculate that the CBF response safeguards substrate delivery during functional activation with a considerable 'safety factor'. Reduction of the CBF response in pathological states may abolish the BOLD-fMRI signal, without affecting underlying neuronal activity.
An Asian Multicenter Clinical Trial to Assess the Efficacy and Tolerability of Acarbose Compared With Placebo in Type 2 Diabetic Patients Previously Treated With Diet (1998)

In this multicenter study involving six ethnic groups, acarbose 100 mg t.i.d. was an effective, safe, and generally well-tolerated therapy in Asian type 2 diabetic patients with dietary failure. In some patients with troublesome gastrointestinal symptoms, a lower dosage may be necessary.
AC Computing Methodology for RF-Powered IoT Devices (2019)

In this paper, an alternating current (ac) computing methodology is proposed for integration into wirelessly powered devices, such as radio-frequency (RF) tags and sensor nodes. Contrary to the traditional platforms that integrate direct current (dc)-powered computational logic along with the rectification and regulation stages, in the proposed approach, the harvested RF signal is directly used to power the data processing circuitry by leveraging the charge-recycling and adiabatic circuit theory. A near-field-based wireless power harvesting system with an 8-bit arithmetic logic unit is developed to evaluate the proposed framework. Simulation results in 45-nm technology demonstrate that the overall power consumption can be reduced by up to 16 times as compared to the conventional approach that relies on ac-to-dc conversion and static CMOS logic. This reduction in power enables significant computation capability for the RF-powered devices. Several important characteristics, such as the impact of circuit size on overhead and processing power, impact of voltage scaling on circuit operation, and power consumption, are investigated. Some important design issues and related tradeoffs are also discussed.
Shimming a superconducting nuclear-magnetic-resonance imaging magnet with steel (1985)

Using a recently published paper as a basis, the magnetic field produced by steel bars inserted in a superconducting NMR imaging magnet is analyzed in a spherically harmonic basis set. A description is then given of how such bars were used to improve the homogeneity of the field within the magnet’s imaging volume from 1.2 parts per thousand to about 10 ppm. The poor homogeneity was caused by the magnet’s being placed in a steel-laden environment, a situation normally shunned by investigators, and it is the author’s contention that the results obtained abrogate the main objection to NMR equipment’s being installed in an ordinary hospital building. To facilitate the latter, the equations developed may also be used to estimate, prior to installation, the effects of the proposed environment on field homogeneity.
Molecular nature of a streptomycin and sulfonamide resistance plasmid (pBP1) prevalent in clinical Escherichia coli strains and integration of an ampicillin resistance transposon (TnA) (1981)

A small, nonconjugative plasmid, designated pBP1, was originally found in different fecal Escherichia coli serotypes isolated from a healthy proband. Of a total number of 130 hospital strains of E. coli subsequently studied, 8.5% yielded plasmid of the pBP1 type. This R plasmid specifies resistance to streptomycin (Sm) and sulfonamides (Su) and has a mass of 4.0 megadaltons. Inactivation of streptomycin is due to the aminoglycoside phosphotransferase APH-(3 "). A physical map was constructed by analysis with restriction endonucleases. Another small plasmid, pBP1-1, was isolated from one of the hospital strains and characterized as an enlarged pBP1 replicon containing an additional deoxyribonucleic acid sequence identified as a transposable element for ampicillin resistance (TnA). Plasmid pBP1-1 was cleaved by restriction enzymes for identification of the transposon sequence which codes for a TEM 1 beta-lactamase. The sequence organizations in the Sm Su plasmids RSF1010 and pBP1 were shown to be identical for regions specifying streptomycin and sulfonamide resistance, but different for the region containing the origin of replication and genes for replicative functions. Thus, RSF1010, which has been considered as the prototype of Sm Su plasmids, and pBP1, which is at least as frequent in clinical isolates as RSF1010, do not have a single common ancestor.
Structured representation of rule-based specifications in CIM using updated Petri nets (1995)

A graphical representation tool-updated Petri nets (UPN)-has been developed to model rule-base specifications for CIM databases. UPN facilitates the modeling of relationships between operations of various manufacturing application systems and the database updates and retrievals among all the respective distributed databases. Based on this representation, a hierarchical modeling technique which includes refining and aggregating rules has also been developed. An application of the UPN is demonstrated in designing rule-based systems for controlling and integrating the information flow between manufacturing applications, including computer aided design, computer aided process planning, manufacturing resources planning, and shop floor control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Monster in the Closet: Declawing the Inequitable Conduct Beast in the Attorney-Client Privilege Arena (2009)

s no end in sight for the profusion of inequitable conduct charges" and even though "the inequitable conduct plague might be less creepy than a pack of locusts, it's no less bothersome to those affected.").3.
An Off–On COX-2-Specific Fluorescent Probe: Targeting the Golgi Apparatus of Cancer Cells (2013)

Identifying cancer cells and quantifying cancer-related events in particular organelles in a rapid and sensitive fashion are important for early diagnosis and for studies on pathology and therapeutics of cancers. Herein a smart "off-on" cyclooxygenase-2-specific fluorescence probe (ANQ-IMC-6), able to report the presence of cancer cells and to image Golgi-related events, has been designed and evaluated. Cyclooxygenase-2 (COX-2) has been used as imaging target in the probe design, since this enzyme is a biomarker of virtually all cancer cell lines. In the free state in aqueous solution, ANQ-IMC-6 mainly exists in a folded conformation where probe fluorescence is quenched through photoinduced electron transfer between the fluorophore acenaphtho[1,2-b]quinoxaline (ANQ) and the recognition group, indomethacin (IMC). Fluorescence is turned on, by restraining the photoinduced electron transfer, when ANQ-IMC-6 is forced to adopt the unfolded state following binding to COX-2 in the Golgi apparatus of cancer cells. ANQ-IMC-6 provides high signal-to-background staining and has been successfully used to rapidly differentiate cancer cells from normal cells when using flow cytometry and one- and two-photon fluorescence microscopic imaging. Furthermore, ANQ-IMC-6 may be able to visualize dynamic changes of the Golgi apparatus during cancer cell apoptosis, with possible application to early diagnosis.
Cloning of a Gene Cluster of<i>aroB</i>,<i>aroE</i>and<i>aroL</i>for Aromatic Amino Acid Biosynthesis in<i>Brevibacterium lactofermentum</i>, a Glutamic Acid-producing Bacterium (1988)

The aroL gene, encoding shikimate kinase of Brevibacterium lactofermentum, a coryneform glutamic acid-producing bacterium, was cloned. Recombinant plasmids containing the aroL gene caused elevated levels of shikimate kinase synthesis in B. lactofermentum. It was found that in addition to the aroL gene, the aroB and aroE genes, encoding dehydroquinate synthase and shikimate dehydrogenase, respectively, also existed on these recombinant plasmids, in complementation tests with various Escherichia coli and B. lactofermentum aromatic amino acid auxotrophs. The aroL, aroB and aroE genes of B. lactofermentum are located closely on the cloned DNA fragment, in that order. It was shown that at least these three aro genes form a cluster on the chromosome of B. lactofermentum.
Comparison of peritonitis rates using standard spike versus Y sets in CAPD. (1989)

Peritonitis is a major source of morbidity for CAPD patients. The "Y" set, which incorporates a "flush before fill" concept, would theoretically decrease peritonitis rates. During Period I 16 new patients began CAPD using the standard spike procedure (Group I). During Period II 10 patients began CAPD using the Y set (Group II). Peritonitis episodes and concomitant exit site infections (ESI) were noted. Time to the first episode of peritonitis (EOP) was estimated using Kaplan-Meier plots; each group was followed for 15 months. In Group I there were 25 EOP in 145.6 patient-months, with three EOP associated with ESI. In Group II there were 3 EOP in 92.77 patient-months and 2 EOP associated with ESI. When the total EOP were considered there was 1 EOP every 5.82 patient-months (Group I) versus 1 EOP every 30.9 patient-months (Group II) (P = 0.0015). When EOP associated with ESI were excluded, peritonitis rates were 1 EOP every 6.61 patient-months (Group I) versus 1 EOP every 92.77 patient-months (Group II) (P = 0.0003). Difference in estimated time to first EOP using Kaplan-Meier plots was also statistically significant for Group II versus Group I (P = 0.0246). The Y set resulted in a statistically significant reduction in peritonitis rates.
Effect of Chewing Bicarbonate-containing Sugar-free Gum on the Salivary pH: An in vivo Study (2016)

The objective of the study was to evaluate the effect of chewing gum on the salivary pH and to compare the effect of chewing bicarbonate-containing sugar-free gum on salivary pH against that of standard sugar-free gum. The experiment was carried out on 30 volunteers aged 20-22 years (mean age = 21 years) who fulfilled the inclusion criteria. The test gum was sugar-free greenmint-flavored bicarbonate-containing gum and the standard control was sugar-free spearmint-flavored gum. The pH was measured immediately using pH strips. According to statistical analysis, the mean salivary pH of the bicarbonate gum at 0, 5, 10, 15 and 20 minutes is 6.9713, 6.5667, 6.4267, 6.3867 and 6.3233 respectively. There is decrease in pH from 0 to 20 minutes. According to Bonferroni, there was no significant difference in pH from 0 to 20 minutes, 10 to 20 minutes and 15 to 20 minutes, but there was a significant difference in salivary pH from 5 to 20 minutes (p = 0.014). The mean salivary pH of the standard gum at 0, 5, 10, 15 and 20 minutes is 6.8767, 6.6067, 6.4200, 6.4027 and 6.3000 respectively. There is decrease in pH from 0 to 20 minutes. According to Bonferroni, there was no significant difference in pH from 0 to 20 minutes, 5 to 20 minutes, 10 to 20 minutes and 15 to 20 minutes. Thus, the higher salivary pH achieved with chewing bicarbonate gum compared with a standard sugar-free gum may have important oral health implications. How to cite this article: Ballal RK, Bhat SS, Ramdas SS, Ballal S. Effect of Chewing Bicarbonate-containing Sugar-free Gum on the Salivary pH: An in vivo Study. Int J Clin Pediatr Dent 2016;9(1):35-38.
Use of porcine tumor necrosis factor receptor 1‐Ig fusion protein to prolong xenograft survival (2004)

Incorporation of strategies that block TNF may prove useful in the development of xenografts resistant to delayed rejection.
Stoichiometry Control and Phase Selection in Hydrothermally Derived Ba <sub>x</sub> Sr <sub>1–x</sub> TiO <sub>3</sub> Powders (1999)

Ba x Sr 1‐ x TiO 3 (BST) powders were processed at temperatures <100°C by reacting nanosized TiO 2 powders in alkaline, aqueous solutions of BaCl 2 , SrCl 2 , and NaOH. The effects of processing variables (NaOH concentration, time, temperature, and the ratios of barium, strontium, and titanium initially in solution) on the resultant BST powder stoichiometry and solid solubility were examined. In all cases, strontium was more readily incorporated into the BST powders than barium, and the extent varied systematically with the processing variables. BST powders that were processed in solutions with a large initial excess of barium and strontium, relative to titanium, consisted of a single‐phase solid solution. In contrast, BST powders that were processed in solutions with a small initial excess of barium and strontium, relative to titanium, contained a biphasic solid solution which corresponded to separate barium‐rich and strontium‐rich phases.
Emergence of HIV Drug Resistance During First- and Second-Line Antiretroviral Therapy in Resource-Limited Settings (2013)

Resistance of HIV to first-line therapy is predictable at 12 months when evaluated by means of HIV RNA monitoring and, when detected, largely preserves second-line therapy options. Optimizing adherence, performing resistance surveillance, and improving treatment monitoring are critical for long-term prevention of drug resistance.
Detection and Reduction of Middle-Frequency Resonance for Industrial Servo with Self-Tuning Lowpass Filter (2012)

A novel method for middle frequency resonance detection and reduction is proposed for speed control in industrial servo systems. Defects of traditional resonance reduction method based on adaptive notch filter in middle frequency range are analyzed. And the main reason is summarized as the difference between the resonance frequency and the oscillation frequency. A self-tuning low-pass filter is introduced in the speed feedback path, whose corner frequency is determined by FFT results and several self-tuning rules. With the proposed method the effective range of the adaptive filter is extended across the middle frequency range. Simulation and Experiment results show that the frequency detection is accurate and resonances during the speed steady states and dynamics are successfully reduced.
Detection limit of negative staining electron microscopy for the diagnosis of bioterrorism-related micro-organisms (2010)

Diagnostic negative staining electron microscopy is used for the diagnosis of pathogens in emergency situations because it allows a rapid examination of all particulate matter down to the nanometre scale. This study provides precise detection limit for the method, an important factor for the validation and improvement of the technique.
Study of New Flow Visualization Technique Using TiO2 Particles in MOCVD Reactor (1991)

The MOCVD technique is one of the most excellent process for the growth of III-V semiconductor epilayers. In this process, epilayer quality(i.e. thickness uniformity) is determined largely by gas-flow dynamics in the reactor.An understanding of gas-flow patterns in the reactor is necessary to obtain the good uniformity of epilayer on a large scale.In this study, we developed a new method of generating micron sized TiO 2 particles by the 2-step reaction of TiCl 4.Using this technique, TiO 2 particles are generated very smooth and thick.We visualized by the scattering of a laser light sheet in a vertical reactorr with top inlet, and could observe stable gas-flow patterns for more than 30 minutes.The experimental results indicate that the fine gas-flow patterns on the 2-inch diameter substrate affects the thickness uniformity strongly.
Connected Components and Credential Hopping in Authentication Graphs (2014)

Modern enterprise computer networks rely on centrally managed authentication schemes that allow users to easily communicate access credentials to many computer systems and applications. The authentication events typically consist of a user connecting to a computer with an authorized credential. These credentials are often cached on the application servers which creates a risk that they may be stolen and used to hop between computers in the network. We examine computer network risk associated with credential hopping by creating and studying the structure of the authentication graph, a bipartite graph built from authentication events. We assume that an authentication graph with many short paths between computers represents a network that is more vulnerable to such attacks. Under this natural assumption, we use a measure of graph connectivity, namely the size of the largest connected component, to give a quantitative indicator of the network's susceptibility to such attacks. Motivated by graph theoretical results for component sizes in random intersection graphs, we propose a mitigation strategy, and perform experiments simulating an implementation using data from a large enterprise network. The results lead to realistic, actionable risk reduction strategies. To facilitate continued research opportunities we are also providing our authentication bipartite graph data set spanning 9 months and 708 million time-series edge records.