gebhart/patrepeval huggingface dataset:
Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy (2014)

5-fluorouracil (5-FU) is the first line component used in colorectal cancer (CRC) therapy however even in combination with other chemotherapeutic drugs recurrence is common. Mutations of the adenomatous polyposis coli (APC) gene are considered as the initiating step of transformation in familial and sporadic CRCs. We have previously shown that APC regulates the cellular response to DNA replication stress and recently hypothesized that APC mutations might therefore influence 5-FU resistance. To test this, we compared CRC cell lines and show that those expressing truncated APC exhibit a limited response to 5-FU and arrest in G1/S-phase without undergoing lethal damage, unlike cells expressing wild-type APC. In SW480 APC-mutant CRC cells, 5-FU-dependent apoptosis was restored after transient expression of full length APC, indicating a direct link between APC and drug response. Furthermore, we could increase sensitivity of APC truncated cells to 5-FU by inactivating the Chk1 kinase using drug treatment or siRNA-mediated knockdown. Our findings identify mutant APC as a potential tumor biomarker of resistance to 5-FU, and importantly we show that APC-mutant CRC cells can be made more sensitive to 5-FU by use of Chk1 inhibitors.
Some unique aspects on ThO2-doped SnO2 exposed to H2 gas (1979)

In ThO2-doped SnO2 exposed to H2 gas, the remarkable phenomenon like the increase of sample resistivity has been found in spite of n-type semiconductors. This phenomenon depends on the gas concentration, the sample temperature, and also the history of the samples. In samples sintered at 600 °C, it appears remarkably at the sample temperature below 240 °C and above 250 ppm of the gas concentration.
NF- <i>kappa</i> B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. (1994)

Expression of the human monocyte chemoattractant protein-1 (hMCP-1) is ubiquitous in various cell types and is increased by a wide variety of stimuli. We initially found that the effects of various stimuli, including IL-1 beta, TNF-alpha, and 2-O-tetradecanoylphorbol 13-acetate, on the expression of hMCP-1 mRNA were quite different among A172 glioblastoma cells, HT1080 fibrosarcoma cells, and SKLMS1 leiomyosarcoma cells. These findings suggested that hMCP-1 expression is regulated both in a stimulus-specific and a tissue-specific manner. To elucidate the mechanism underlying this stimulus-specific and tissue-specific regulation, we isolated a hMCP-1 5'-flanking genomic DNA fragment and sequenced it extensively up to bp 3011 upstream from the transcriptional start site. Among many putative cis-elements, we identified two cis-elements critical for the transcription of the hMCP-1 gene. The first element is a remote kappa B binding site located far upstream between bp -2612 and -2603 that was important for IL-1 beta-, TNF-alpha-, and 2-O-tetradecanoylphorbol 13-acetate-induced enhancer activity. Mutation at the kappa B consensus site resulted in a complete loss of these stimulus-induced enhancer activities. The second element is a GC box located between bp -64 and -59 that was important for the maintenance of basal transcriptional activity. Overexpression of rSp1 resulted in increased hMCP-1 transcriptional activity, possibly suggesting the role of Sp1 in controlling basal hMCP-1 transcription via this GC box. These results together indicate that hMCP-1 expression is controlled by at least two distinct regulatory elements: a kappa B site and a GC box that seem to be associated with stimulus-specific and tissue-specific regulation, respectively.
The recovery of proteolytic activity using the Salivette system. (1995)

The recovery of proteolytic activity from human saliva was investigated using the Salivette system. Comparison of activity measurements with those obtained from whole saliva indicated that the Salivette system allowed increased recovery of proteolytic activity suggesting minimal enzyme binding to the cotton roll. The significance of these results is that previous estimates of proteolytic activity in mixed saliva may not have been due to increasing release of proteases by stimulation of secretion, but by altered binding properties of the sampling system used.
Effect of pressure on entrainment flow rate in vertical upwards gas—liquid annular two-phase flow. Part I: Experimental results for system pressures from 0.3 MPa to 20 MPa (1996)

The purpose of this study is to investigate the pressure effects on the entrainment flow rates in vertical gas—liquid annular two-phase flow. The cross-sectional entrainment flow rates were measured using an isokinetic probe method. It was found that the behavior of cross-sectional entrainment flow rate profiles is divided into low- and high-pressure regions. Also, the entrainment flow rates amount to 90 percent of the total liquid flow rate under high-pressure conditions. In this study, system pressure in the closed-loop system was changed substantially from 0.3 MPa to 20 MPa at a constant fluid temperature in vertical upward flow. © 1997 Scripta Technica, Inc. Heat Trans Jpn Res, 25(5): 267–280, 1996
Novel schemes for optical signal generation using laser injection locking with application to Brillouin sensing (2004)

Injection locking of two DFB semiconductors opens new possibilities to generate effective signals for optical sensing, in order to reach better performances. Pure wave forms can be generated with qualities exceeding those obtained using external modulators. This is illustrated through the application to the distributed Brillouin sensing that shows significant progress with respect to established techniques. Â© 2004 IOP Publishing Ltd.
Cost aware fault tolerant logic synthesis in presence of soft errors (2010)

With the emergence of sub-100 nanometers, soft error failure rates (SER) due to Single-event Upsets (SEU) from particle strikes become unacceptable for combinational logic circuits. Triple modular redundancy (TMR) is applied to improve the reliability of VLSI circuits, entailing additional cost (area, delay, power consumption, e.g.). This paper introduce a partial TMR solution to optimize the area of fault tolerant VLSI circuits with SER constraints, presenting a novel optimization method by Binary Integer Linear Programming (BILP) with components consideration,. It also proposes an efficient SER evaluation model base on linear gate error propagation. A series of simulation on NCMC'89 benchmark is made. The experiment results show that this technique improves reliability by an average 57.95% with only 36.98% area overhead.
Design and Evaluation of a Wearable Optical Sensor for Monitoring Seated Spinal Posture (2006)

This work describes the development and evaluation of a wearable plastic optical fiber (POF) sensor for monitoring seated spinal posture. A garment-integrated POF sensor was developed and tested on nine healthy subjects, and its performance compared to data taken simultaneously from a marker-based motion capture system. Sensor performance correlated strongly with motion-capture data with an average r of 0.913. Results show that the wearable sensor provides enough accuracy of measurement to reliably monitor seated spinal posture.
Generalised minimum distance decoding of Reed-Muller codes and Barnes-Wall lattices (2002)

Low complexity soft decision decoding algorithms for Reed-Muller codes and Barnes-Wall lattices are presented. These algorithms are constructed based on the usage of generalised minimum distance (GMD) decoding recursively. Evaluation of the algorithms on AWGN channel through computer simulation indicates a slight degradation in performance, compared to maximum likelihood decoding, but with considerable reduction in complexity.
Remote-collaboration system using mobile robot with camera and projector (2006)

We have been studying a remote-collaboration system called SCOPE (sight collaboration by projection effect) featuring image projecting and capturing capabilities as implemented in a maintenance robot. With the help of SCOPE and a remote support person, an on-site worker can perform maintenance very efficiently. We propose a mobile SCOPE that can significantly expand the area of activity of the conventional SCOPE. To enable an on-site worker to share the field of view of a remote support person, we developed a technique for aligning the optical axes of a camera and a projector. We present experimental data that demonstrates the validity of our optomechanical design. Finally, we show that the mobile SCOPE enables workers to continuously share their field of view, no matter where the mobile SCOPE moves
Theoretical and Experimental Study of the <sup>13</sup>C Chemical Shift Tensors of Acetone Complexed with Brønsted and Lewis Acids (1998)

We calculated the chemical shift tensors for acetone and 12 complexes of acetone with Brønsted and Lewis acids. Each complex was optimized at the MP2/6-311+G* or B3LYP/DZVP2 level of theory. Chemical shift tensors were calculated with the gauge including atomic orbital (GIAO) approach at the RHF and MP2 levels of theory. We discovered a strong correlation between the MP2 and RHF 13C isotropic shifts of the carbonyl carbon in the complexes studied. Linear regression indicates that the MP2 isotropic shifts can be predicted by δMP2 = [1.12 (±0.04)]δRHF − 42.1 (±10.5) ppm (R2 = 0.9974). We were thus able to study two systems that are currently intractable at the GIAO-MP2 level. One is the complex of acetone with a large model of a zeolite, (H3SiO)3SiOHAl(OSiH3)3. The RHF shift of the carbonyl carbon of acetone on the zeolite model (238.4 ppm) is in poor agreement with the experimental (223 ppm) value. However, the MP2 result predicted by the linear correlation (224.0 ppm) is in much closer agreement. We were also able to study acetone adsorbed on aluminum chloride powder models. We find that acetone·AlCl3 is a poor adsorption model, as demonstrated by a large discrepancy between experimental and calculated MP2 shifts. However, the MP2 shift from the regression equation (244.7 ppm) for acetone complexed to the larger Al2Cl6 cluster is in excellent agreement with the experimental result (245 ppm). We also report experimental measurements of the principal components of the carbonyl 13C shift tensor for a variety of solid acids, including frozen oleum and frozen SbF5.
A synoptic review of the classification of red algal genera a half century after Kylin's “<i>Die Gattungen der Rhodophyceen</i>” (2007)

Abstract Classification of the red algae (Rhodoplantae) has undergone significant change since the seminal work of Harald Kylin, “ Die Gattungen der Rhodophyceen ,” a half century ago. The number of genera has nearly doubled over this time period, at least in part due to recent molecular comparative work. Information gleaned from gene-sequencing analyses has resulted in a red algal classification that reflects a more accurate phylogenetic framework than that based solely on morphological data. This paper tabulates the known 834 genera of red algae today with taxonomic synonyms and literature references reflecting the great change over fifty years.
Amplifier Efficiencies of OFDM Systems with Peak Power and Envelope Variance Reduction (2006)

In this paper, we evaluate several dynamic range reduced OFDM systems in terms of power amplifier (PA) efficiency. We point out that when nonlinear amplification is allowed to some extent, as is often the case with practical wireless systems, the distribution of envelope, rather than that of peak-to-average power ratio (PAR), is a more relevant measure. Thus, we focus on the techniques which attempt to flatten the envelope variance such as clipping and filtering and trellis shaping, rather than those reducing a probability of occurrence of high PAR symbols. Numerical results show how much power efficiency savings are achievable by means of these techniques
Organie Dye for Subsea Flowline Assessment (1999)

Abstract Specific chemical additives are frequently used in the petroleum industry in order to obtain information regarding the flow conditions of water and oil in pipelines and reservoirs. The application of tracer agents supplies information, such as the free volume from a subsea pipeline under wax deposition. Among the available organic dyes, fluorescein is the most efficient tracer agent. Fluorescein exhibits intense fluorescence when in alkaline solution, under incidence of visible, or ultra-violet light and in concentrations of the order of 0.1 to 10 ppm. In order to simplify the method for determining the free volume in subsea pipelines, a study was undergone for adapting an organic dye of strongly oleophilic nature. In this sense a derivative of fluorescein in the form of an ester of a higher alcohol was used, the main feature of which is its non-ionic character and its high solubility in a non-polar liquid, which renders possible its incorporation in the flow of the petroleum oil being produced, or in usual non-polar solvents such as kerosene, diesel oil or xylene. The tracer agent originally soluble in the oil phase, when submitted to an alkaline treatment becomes fully soluble in water, and may be colorimetrically monitored The free volume of the pipelines may be accurately determined up to 98% by using this method. Solubility experiments of the coloring were accomplished in several organic solvents, with subsequent alkaline extraction for several conditions. The conversion yields of the active principle of the dyes were determined by photometric methods.
Dramatic response to topical timolol lotion of a large hemifacial infantile haemangioma associated with PHACE syndrome (2010)

Funding sources: none. Conflicts of interest: none declared. Madam, The PHACE syndrome is an uncommon condition seen in a subgroup of children, particularly associated with large segmental facial haemangiomas. It is an acronym coined by Frieden et al.1 for the association of Posterior fossa defects, Haemangiomas, Arterial anomalies, Cardiac defects and Coarctation of the aorta, and Eye anomalies. The ‘S’ in PHACES syndrome signifies associated Sternal clefting and/or Supraumbilical raphe. The haemangiomas associated with PHACE syndrome are typically large, prone to ulceration, and generally require treatment. Traditional treatment options for haemangiomas include observation, systemic and intralesional corticosteroids, interferon alfa‐2a, vascular lasers, sclerotherapy, embolization, immunomodulators and surgery.2 3–4 The first use of a beta blocker, oral propranolol, for infantile haemangiomas was reported in 2008.5 However, systemic propranolol carries a risk of serious adverse effects including bradycardia, arrhythmias, hypotension and hypoglycaemia.6 Children with PHACES syndrome may have cerebrovascular anomalies and oral propranolol can be a contraindication in these patients owing to the risk of cerebral ischaemia.6 The use of another beta blocker, topical timolol, was reported in the treatment of a thin eyelid haemangioma.7 To the best of our knowledge, this therapy has not been previously reported in the treatment of a large ulcerating haemangioma with PHACE syndrome.
A Photometric Study of Saturn and Its Rings (1974)

A 72-in. telescope and a polarimeter of the Wollaston type with a focal-plane scanning mechanism were used in the investigations reported. On a few occasions observations were made with a 42-in. reflector. The polarization data obtained are presented as vectors superimposed on a drawing of the planet. It is concluded that in the ultraviolet and close to opposition the vectors are consistently radial and decrease to nearly zero near the center of the disk. The polarization is essentially the same at all limbs. It is pointed out that under good seeing conditions Saturn presents a consistent though somewhat complicated, photometric pattern.
Quelques données sur les propensions à l’endogamie et à l’exogamie de la nuptialité ethnique au Québec (2008)

Les transferts linguistiques établis par les populations allophones ont fait au Québec l’objet d’un bon nombre d’études démographiques et sociologiques. Elles ont en outre très généralement mis en évidence la préférence manifeste des allophones pour l’anglais et tout ce que ces choix linguistiques traduisent en termes de comportement social, économique et politique. Le présent article s’inscrit dans cet ensemble d’études en tentant de dégager, à partir des statistiques du recensement de 1971 sur l’origine ethnique des conjoints des familles époux-épouse au Québec et dans le reste du Canada, les préférences ethniques qui s’y expriment et qui illustrent, dans une certaine mesure, les dynamiques respectives des relations interethniques des deux contextes socio-politiques choisis.
Convolutional Networks for Shape from Light Field (2016)

Convolutional Neural Networks (CNNs) have recently been successfully applied to various Computer Vision (CV) applications. In this paper we utilize CNNs to predict depth information for given Light Field (LF) data. The proposed method learns an end-to-end mapping between the 4D light field and a representation of the corresponding 4D depth field in terms of 2D hyperplane orientations. The obtained prediction is then further refined in a post processing step by applying a higher-order regularization. Existing LF datasets are not sufficient for the purpose of the training scheme tackled in this paper. This is mainly due to the fact that the ground truth depth of existing datasets is inaccurate and/or the datasets are limited to a small number of LFs. This made it necessary to generate a new synthetic LF dataset, which is based on the raytracing software POV-Ray. This new dataset provides floating point accurate ground truth depth fields, and due to a random scene generator the dataset can be scaled as required.
Hierarchical approach to term suggestion device (2002)

Our demonstration shows the hierarchy system working on a locally run search engine. Hierarchies are dynamically generated from the retrieved documents, and visualised on the menus. When a user selects a term from the hierarchy, the documents linked to the term are listed, and the term is then added to the initial query to rerun a search. Through the demonstration we illustrate how hierarchical presentation of expansion terms is achieved, and how our approach supports users to articulate their information needs using the hierarchy.
Low-Loss Patterned Ground Shield Interconnect Transmission Lines in Advanced IC Processes (2007)

In this paper, we provide an extensive experimental and theoretical study of the benefits of patterned ground shield interconnect transmission lines over more conventional layouts in advanced integrated-circuit processes. As part of this experimental work, we present the first comparative study taken on truly differential transmission line test structures. Our experimental results obtained on transmission lines with patterned ground shields are compared against a predictive compact equivalent-circuit model. This model employs exact closed-form expressions for the inductances, and describes key performance figures such as characteristic impedance and attenuation loss with excellent accuracy
Properties and reactions of 1-methyl-3-phospholanone 1-oxide (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties and reactions of 1-methyl-3-phospholanone 1-oxideLouis D. Quin and Ronald C. StocksCite this: J. Org. Chem. 1974, 39, 5, 686–690Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jo00919a023https://doi.org/10.1021/jo00919a023research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acupuncture treatment of simple obesity. (2005)

In order to investigate the therapeutic effects of ear acupuncture, body acupuncture and the combined use of the two in the treatment of simple obesity, 195 cases of obesity were divided into three groups, in which different reinforcing and reducing methods were applied according to their symptoms and signs. The effects of body acupuncture and body plus ear acupuncture were obviously superior to that of ear acupuncture, and the combined use of ear acupuncture and body acupuncture was better than that of simple body acupuncture.
Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite (2017)

While most subunit malaria vaccines provide only limited efficacy, pre-erythrocytic and erythrocytic genetically attenuated parasites (GAP) have been shown to confer complete sterilizing immunity. We recently generated a Plasmodium berghei (PbNK65) parasite that lacks a secreted factor, the histamine releasing factor (HRF) (PbNK65 hrfΔ), and induces in infected mice a self-resolving blood stage infection accompanied by a long lasting immunity. Here, we explore the immunological mechanisms underlying the anti-parasite protective properties of the mutant PbNK65 hrfΔ and demonstrate that in addition to an up-regulation of IL-6 production, CD4<sup>+</sup> but not CD8<sup>+</sup> T effector lymphocytes are indispensable for the clearance of malaria infection. Maintenance of T cell-associated protection is associated with the reduction in CD4<sup>+</sup>PD-1<sup>+</sup> and CD8<sup>+</sup>PD-1<sup>+</sup> T cell numbers. A higher number of central and effector memory B cells in mutant-infected mice also plays a pivotal role in protection. Importantly, we also demonstrate that prior infection with WT parasites followed by a drug cure does not prevent the induction of PbNK65 hrfΔ-induced protection, suggesting that such protection in humans may be efficient even in individuals that have been infected and who repeatedly received antimalarial drugs.
Quantitative Evaluation of Drug-Induced Erythema by Using a Tristimulus Colour Analyzer: Experimental Design and Data Analysis (1993)

Pulsed-light reflectance using the Minolta Chroma Meter CR-200 was evaluated as a quantitative method for the noninvasive assessment of drug-induced erythema on the flexor surface of the forearm. Nicotinate esters were used as model vasodilators. Several parameters derived from the data were analysed using analysis of variance (ANOVA) and Tukey's multiple range tests appropriate for the study designs used. The effects of varying concentrations of methylnicotinate and of different nicotinate esters were found to be statistically significant. This non-invasive technique was found to be particularly useful in ranking the cutaneous responses elicited by the topical application of increasing concentrations of methylnicotinate in a single subject, as well as in a group of 6 volunteers.
ChemInform Abstract: Derivatives in the Vitamin E Series. Part 1. Synthesis and Reactions of all‐rac‐5‐Formyl‐γ‐tocopherol (I). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.