gebhart/patrepeval huggingface dataset:
Therapeutic effects of hepatocyte growth factor‐overexpressing human umbilical cord blood‐derived mesenchymal stem cells on liver fibrosis in rats (2013)

Fibrosis is a common end stage for a variety of liver diseases, including most chronic liver diseases, and results from an imbalance between collagen deposition and degradation. Mesenchymal stem cells (MSCs) have the ability to migrate into fibrotic livers and differentiate into hepatocytes. Hepatocyte growth factor (HGF) has potent anti-apoptotic and mitogenic effects on hepatocytes during liver injury and plays an essential role in the development and regeneration of the liver. In this study, human HGF-overexpressing human umbilical cord blood-derived MSCs (hHGF-HUCB-MSCs) were prepared using the pMEX Expression System, and the upregulation of hHGF expression was confirmed by RT-PCR and ELISA. HGF expressed by hHGF-HUCB-MSCs exerted a stimulatory effect on hepatocyte proliferation in vitro. hHGF-HUCB-MSCs were transplanted to investigate the therapeutic effects of these cells on carbon tetrachloride (CCL4)-induced liver fibrosis in a rat model. After 4 weeks of cell treatment once per week with 2 × 10(6) cells, biochemical analysis of the serum and histopathological analysis of the liver tissue were performed. The results of the biochemical analysis of the serum show that the hHGF-HUCB-MSC-treated group had higher levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase, indicating the improvement of liver function. Histopathology showed that the hHGF-HUCB-MSC-treated group had reduction in the density of collagen fibres. Thus hHGF-HUCB-MSCs can enhance liver regeneration and could be useful for the treatment of patients with liver fibrosis or cirrhosis.
MIMO-OFDM Transmission Employing Subcarrier-Block Phase Hopping for PAPR Reduction (2007)

This paper proposes a MIMO-OFDM transmission scheme employing subcarrier-block phase hopping that can reduce peak-to-average power ratio (PAPR) while simultaneously improving transmission performance with low numerical complexity. As a conventional scheme for achieving these objectives, a combination of the enhanced selected mapping (ESLM) and the subcarrier phase hopping for space division multiplexing (SPH-SDM) has been proposed. To reduce the complexity furthermore and to increase feasibility of hardware implementation, the proposed scheme enhances SPH-SDM by introducing subcarrier-block phase hopping based on the partial transmit sequence (PTS). It divides the overall subcarriers into blocks and rotates phases of the complex signals which IFFT generates from the subcarriers of each block. Computer simulations demonstrate that the proposed scheme can drastically reduce PAPR and improve the packet error rate (PER) in comparison with the standard MIMO-OFDM, and that it can achieve almost the same performance as SPH-SDM with ESLM while achieving half as low complexity as that of the conventional one.
An electron imaging approach to soft-x-ray transmission spectromicroscopy (1996)

We tested a new soft-x-ray transmission spectromiscropy technique on the Aladdin storage ring at the Wisconsin Synchrotron Radiation Center. Transmitted x rays were converted with a photocathode into photoelectrons, which were subsequently electron-optically processed by an x-ray secondary electron-emission microscope producing submicron-resolution images. Test images demonstrated the excellent contrast due to the chemical differences between silicon features and a silicon nitride substrate. We also obtained x-ray transmission versus photon energy curves for microscopic specimen areas.
The Role of <i>PHANTASTICA</i> in Leaf Development (2004)

Plant leaves occur in a fantastic variety of sizes and shapes, and the genetic mechanisms behind this variation have long fascinated and challenged plant biologists. Leaves are produced laterally off of the main shoot axis, and may be simple, with a single blade (or lamina) extending from the
A Fiber Optic Interferometric Sensor For Dynamic Measurement (2007)

An optical fiber Fabry-Perot interferometer (FFPI) is proposed and demonstrated for dynamic measurements in a mechanical vibrating target. A polishing metal with a low reflectance value adhered to a mechanical vibrator was excited via a function generator at various excitation frequencies. Output interference fringes were generated by modulating the reference and sensing signal at the output arm. A fringe-counting technique was used for interpreting the displacement information on the dedicated computer. The fiber interferometer has been found the capability of the displacement measurements of 1.28 μm – 96.01 μm. A commercial displacement sensor was employed as a reference sensor for investigating the measurement errors from the fiber sensor. A maximum percentage measurement error of approximately 1.59 % was obtained.
Performance of the census UNIVAC system (1951)

In June of 1948 the National Bureau of Standards acting on behalf of the Bureau of the Census contracted with the Eckert-Mauchly Computer Corporation for a UNIVAC System. This UNIVAC System, now generally known as the Census UNIVAC System, was accepted on March 30, 1951, and since that time has been devoted almost exclusively to tabulating results of the 1950 Census of Population and Housing.
UV-Laser-Induced Decomposition of Kapton Studied by Infrared Spectroscopy (2000)

The UV-laser (308 nm)-induced decomposition and ablation of polyimide (Kapton) was studied using diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. The samples were prepared with a special technique (SiC substrates) allowing analysis of surface species of the laser-treated polymer. The first step of photolysis is the simultaneous decomposition of the imide ring, between the nitrogen and carbonyl carbon atom, and of the diaryl ether group. The functional groups belonging to the corresponding amide and carbonyl system are detected. In the next step the aromatic system decomposes, and isocyanates, aliphatic hydrocarbons, nitriles, and alkynes are formed. Volatile species compatible with this decomposition mechanism (CO, CO2, HCN, and C2H2) are detected by additional mass spectrometry measurements.
Selamectin is a potent substrate and inhibitor of human and canine P‐glycoprotein (2005)

The transport of the antiparasitic agents, ivermectin, selamectin and moxidectin was studied in human intestinal epithelial cell monolayers (Caco-2) and canine peripheral blood lymphocytes (PBL). Both models expressed the mdr1-coded 170 kDa ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp). Fluxes of the P-gp substrate rhodamine-123 (Rh-123) across Caco-2 monolayers showed that ivermectin and selamectin acted as potent P-gp inhibitors with IC50 values of 0.1 microm. In contrast, moxidectin was a weaker P-gp inhibitor with an IC50 of 10 microm. The transport of radiolabelled ivermectin, selamectin and moxidectin through Caco-2 monolayers showed that ivermectin, selamectin and moxidectin were P-gp substrates with secretory/absorptive ratios of 7.5, 4.7 and 2.6 respectively. Secretory transport of [3H]-ivermectin and [3H]-selamectin was blocked by the P-gp inhibitor, verapamil. Ivermectin and selamectin inhibited the efflux of Rh-123 from PBL and the concentration of inhibition was similar to that of verapamil. In contrast, moxidectin did not have a significant effect on Rh-123 efflux from PBL. The data suggest that ivermectin and selamectin are potent P-gp substrates, while moxidectin is a weak one.
Design and evaluation of a peptide‐based immunotoxin for breast cancer therapeutics (2015)

Immunotoxins are chimeric proteins comprising a specific cellular targeting domain linked to a cytotoxic factor. Here we describe the design and use of a novel, peptide-based immunotoxin that can initiate selective cytotoxicity on ErbB2-positive cells. ErbB2 is a receptor tyrosine kinase that is overexpressed in the tumor cells of approximately 30% of breast cancer patients. Immunotoxin candidates were designed to incorporate a targeting ligand with affinity for ErbB2 along with a membrane lysin-based toxin domain. One particular peptide candidate, NL1.1-PSA, demonstrated selective cytotoxicity towards ErbB2-overexpressing cell lines. We utilized a bioengineering strategy to show that recombinant NL1.1-PSA immunotoxin expression by Escherichia coli also conferred selective cytotoxicity towards ErbB2-overexpressing cells. Our findings hold significant promise for the use of effective immunotoxins in cancer therapeutics.
Polycrystalline thin-films. FY 1985 annual report (1986)

This annual report summarizes the status, accomplishments, and projected future research directions of the Polycrystalline Thin Film Task in the Photovoltaic Program Branch of the Solar Energy Research Institute's Solar Electric Research Division. Major subcontracted work in this area has concentrated on development of CuInSe/sub 2/ and CdTe technologies. During FY 1985, major progress was achieved by subcontractors in (1) developing a new, low-cost method of fabricating CuInSe/sub 2/ and (2) improving the efficiency of CuInSe/sub 2/ devices by about 10% (relative). The report also lists research planned to meet the department of Energy's goals in these technologies.
Service-Oriented Development of Workflow-Based Semantic Reasoning Applications (2014)

The modern Semantic Web scenarios require reasoning algorithms to be flexible, modular, and highly-configurable. A solid approach, followed in the design of the most currently existing reasoners, is not sufficient when dealing with today's challenges of data analysis across multiple sources of heterogeneous data or when the data amount grows to the “Big Data” sizes. The “reasoning as a workflow” concept has attracted a lot of attention in the design of new-generation Semantic Web applications, offering a lot of opportunities to improve both flexibility and scalability of the reasoning process. Considering a single workflow component as a service offers a lot of opportunities for a reasoning algorithm to target a much wider range of potentially enabled Semantic Web use cases by taking benefits of a service-oriented and component-based implementation. We introduce a technique for developing service-oriented Semantic Reasoning applications based on the workflow concept. We also present the Large Knowledge Collider - a software platform for developing workflow-based Semantic Web applications, taking advantages of on-demand high performance computing and cloud infrastructures.
New Stigmatic XUV Plane Gratings Spectrometers (1986)

In this paper we describe new types of VUV monochromators using only plane type V holographic gratings. New design rules using physical optics associated with the phase balancing method are suggested to achieve super resolution.
Synthesis of α- and β-Glycosyl Asparagine Ethylene Isosteres (<i>C</i>-Glycosyl Asparagines) via Sugar Acetylenes and Garner Aldehyde Coupling (2002)

A convergent approach has been developed for the synthesis of C-glycosyl amino acids in which the glycinyl moiety CH(NH2)CO2H is connected to the anomeric center of the sugar residue by a three carbon atom tether. Essentially, these compounds are isosteres of N-glycosyl asparagines in which the amide group has been replaced by an ethylene bridge. Following the coupling of alpha- or beta-D-linked lithium C-glycoside acetylides with N-Boc D-serinal acetonide (Garner aldehyde), the resulting adducts were transformed into the final N-Boc-C-glycosyl-alpha-aminopentanoic acids via reduction of the triple bond, deoxygenation, and oxidative cleavage of the oxazolidine ring. By this protocol, 12 C-glycosyl asparagines, six pairs of alpha- and beta-anomers, have been prepared incorporating the gluco, galacto, manno, and the corresponding 2-acetamido-2-deoxy residues.
Design, fabrication, and evaluation of a new haptic device using a parallel mechanism (2001)

This paper presents design, fabrication, and evaluation of a new 6-DOF haptic device for interfacing with virtual reality by using a parallel mechanism. The mechanism is composed of three pantograph mechanisms that are driven by ground-fixed servomotors, three spherical joints between the top of the pantograph mechanisms and the connecting bars, and three revolute joints between the connecting bars and a mobile joystick handle. Forward and inverse kinematic analyses are performed and the Jacobian matrix is derived. Performance indexes such as global payload index, global conditioning index, translation and orientation workspaces, and sensitivity are evaluated to find optimal parameters in the design stage. The proposed haptic mechanism has better load capability than those of the pre-existing haptic mechanisms due to the fact that the motors are fixed at the base. It has also a wider orientation workspace mainly due to a RRR-type spherical joint. A control method is presented with gravity compensation and force feedback by a force/torque sensor to compensate for the effects of unmodeled dynamics such as friction and inertia. Also, the dynamic performance is evaluated for force characteristics. Virtual wall simulation with the developed haptic device is demonstrated.
Experiencia de innovación en el aula desde la autorregulación y los estilos de aprendizaje (2018)

The purpose of this document is to contribute the conclusions obtained by the teachers of Centro Universitario Escuni, on the relations between self - regulation and learning styles in students of the Kinder and Primary Education. These conclusions have been drawn after years of research on the theory of learning styles and with the implementation of a methodological model focused on self-regulation learning. The theoretical reference of this study is based in Kolb's (1984) approach to learning styles and, on the other hand, Pintrich's (2000) model of self-regulation learning. The findings obtained indicate the teacher's orientation of the self-regulating processes of learning from the knowledge of the learning styles of the students and, also, from an exercise of self-knowledge and self-awareness of the student, to acquire greater academic and formative competences.
Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics (2013)

Co-immunoprecipitation (co-IP) has become a standard technique, but its protein-band output provides only static, qualitative information about protein-protein interactions. Here we demonstrate a real-time single-molecule co-IP technique that generates real-time videos of individual protein-protein interactions as they occur in unpurified cell extracts. By analysing single Ras-Raf interactions with a 50-ms time resolution, we have observed transient intermediates of the protein-protein interaction and determined all the essential kinetic rates. Using this technique, we have quantified the active fraction of native Ras proteins in xenograft tumours, normal tissue and cancer cell lines. We demonstrate that the oncogenic Ras mutations selectively increase the active-Ras fraction by one order of magnitude, without affecting total Ras levels or single-molecule signalling kinetics. Our approach allows us to probe the previously hidden, dynamic aspects of weak protein-protein interactions. It also suggests a path forward towards precision molecular diagnostics at the protein-protein interaction level.
Performance Assessment of Feature Detector-Descriptor Combination (2015)

Features detection and description among multiple images are widely used in many applications, e.g., feature matching, object categorization, 3D construction, image retrieval and object recognition. This paper evaluates combination performance of different feature detectors and descriptors. It will compare performance of detectors and descriptors combination on images under rotate, scale constraints and distortion such as illumination on different scene (bedroom, industrial and CALsuburb). An experimental result shows MinEigen detector has best result in number of detected key-points when handle rotate, scale and illumination and not affected with scene. SURF without external detector is the best when handle rotate and scale constraint in different levels and scene. FAST/SURF and Harris/FREAK are best combined against illumination distortion in different levels. This review introduces a brief introduction for providing a new research in feature detection field to find appropriate method according to their condition.
Vestigial Side Band Demultiplexing for Ultra High Capacity (0.64 bit/s/Hz) Transmission of 128×40 Gb/s Channels (2001)

Vestigial sideband filtering with high crosstalk suppression is demonstrated as optical demux of densely packed 40 Gb/s channels with high spectral efficiency of 0.64 bit/s/Hz. Narrow band optical filters have been applied for separation of 128×40 Gbit/s channels with alternating spacings of 50 and 75 GHz.
Discrete Logarithms and Factoring (1984)

This note discusses the relationship between the two problems of the title. We present probabilistic polynomial-time reductions that show: <br />1) To factor <i>n</i>, it suffices to be able to compute discrete logarithms modulo <i>n</i>. <br />2) To compute a discrete logarithm modulo a prime power <i>p^(e)</i>, it suffices to know it mod <i>p</i>. <br />3) To compute a discrete logarithm modulo any <i>n</i>, it suffices to be able to factor and compute discrete logarithms modulo primes. <p>To summarize: solving the discrete logarithm problem for a composite modulus is exactly as hard as factoring and solving it modulo primes
High Temperature, High Pressure Water Level Sensor (1980)

A sensor was developed to measure water level over a range of 750 mm with an uncertainty of +- 20 mm at a temperature from 20 to 250/sup 0/C and pressure up to 15.2 MPa. The sensor is type 304, flattened stainless steel rod. Its cross section is 1.6 x 3.2 mm, and its measured torsional transit time is a function of water density rho, level L, and temperature T. To minimize the influence of T, the extensional transit time is also measured in the same sensor. To interrogate the sensor with both modes, Joule and Wiedemann transducers are multiplexed in an alternating sequence. Experimental results, problems, and remedies are discussed.
<i>C</i><sub>2</sub>‐Symmetric Cationic Copper(<scp>II</scp>) Complexes as Chiral Lewis Acids: Counterion Effects in the Enantioselective Diels–Alder Reaction (1995)

Alone a tailor-made chiral cationic Lewis acid is not sufficient to achieve high enantiomic excesses in Diels–Alder reactions; the counterion can dramatically affect the efficiency of the chiral catalyst. Thus, for example, the enantioselectivities reached in these reactions in the presence of the copper complex 1 with X = SbF6 as counterion are in some cases substantially greater than those with X = OSO2CF3.
Exchange anisotropy in coupled films of Ni81Fe19 with NiO and Co<i>x</i>Ni1−<i>x</i>O (1992)

Shifted hysteresis loops were used to investigate exchange anisotropy in 500 Å CoxNi1−xO/300 Å Ni81Fe19 polycrystalline bilayer couples. Bilayers of Ni81Fe19 with NiO have a room-temperature exchange field, He, of 30 Oe in the as-deposited state. A maximum in the exchange field at room temperature was observed near x=0.4, indicating an optimal alloying of the properties of the high anisotropy CoO and the high Néel temperature NiO. The blocking temperatures of the exchange couples vary linearly with x, suggesting a linear dependence of the oxide Néel temperature with x.
Effects of <i>in vivo</i> administration of G‐CSF on neutrophil and eosinophil adhesion (1997)

The effect in vivo of G-CSF on neutrophil and eosinophil adhesion was studied after subcutaneous administration to six healthy individuals of human recombinant glycosylated G-CSF (lenograstim) (3 micrograms/kg) for 6 consecutive days. Basal adhesion and adhesion to E-selectin. VCAM-1 and ICAM-1 of neutrophil and eosinophil granulocytes were measured selectively. During G-CSF administration neutrophil basal adhesion increased from 7.4 +/- 3.9% (mean +/- SD) to 55.8 +/- 12.9% and 23.2 +/- 4.4%, 4 and 7 d, respectively, after start of the administration. At the same time points eosinophil basal adhesion increased from 7.1 +/- 2.4% to 37.7 +/- 6.1% and 13.1 +/- 5.3%, respectively. When adhesion was measured in the presence of Mn2+, which increases the functional activity of integrins, an even higher increase of neutrophil and eosinophil basal adhesion was noted 4 and 7 d, respectively, after start of G-CSF administration. In parallel with the enhanced basal adhesion neutrophil adhesion to E-selectin and ICAM-1 and eosinophil adhesion to E-selectin. VCAM-1 and ICAM-1 were significantly (P < 0.05) increased after 4 d of G-CSF administration as was neutrophil cell surface expression of CD11b and CD18. In vitro G-CSF induced minimal changes of granulocyte basal adhesion and inhibition of the adhesion to E-selectin. 10 ng/ml TNF alpha significantly increased neutrophil and eosinophil basal adhesion and adhesion to VCAM-1 and ICAM-1. In summary, administration of G-CSF to healthy subjects induced enhanced adhesion of neutrophil and eosinophil granulocytes, probably mediated by an increase of the functional capacity of beta 1- and beta 2-integrins. The induction of increased levels of TNF alpha might be one mechanism behind the in vivo effect of G-CSF administration.
Development of Alternative Glass Ceramic Seal for a Planar Solid Oxide Fuel Cell (2012)

LZSA glass ceramic (LiO 2 -ZrO 2 -SiO 2 -Al 2 O 3 ) was tested for its thermomechanical compatibility as a sealing material with a stainless steel interconnect (AISI 430) of a planar SOFC. With this purpose, the densification and crystallization behavior of LZSA were investigated initially. It was observed that the material reached maximum relative density and shrinkage, respectively 95% and 17%, at 800°C, which corresponded approximately to the crystallization temperature of the material as evidenced by DTA analysis. In the next step, LZSA tapes were cast from slurries and prepared either as LZSA laminates or LZSA-steel bilayers. The densification behavior and microstructural features of cofired LZSA laminates and LZSA-steel bilayers were analyzed at 800 and 900°C. Maximum relative density and defect-free interfaces were observed for laminates and bi-layers cofired at 800°C, whereas increased porosity and detached bi-layer were the characteristics of the samples fired at 900°C.
Assignment of a second Charcot-Marie-Tooth type II locus to chromosome 3q. (1995)

Charcot-Marie-Tooth disease (CMT) is the most common inherited motor and sensory neuropathy. The neuronal form of this disorder is referred to as Charcot-Marie-Tooth type II disease (CMT2). CMT2 is usually inherited as an autosomal dominant trait with a variable age at onset of symptoms associated with progressive axonal neuropathy. In some families, the locus that predisposes to CMT2 has been demonstrated to map to the distal portion of the short arm of chromosome 1. Other families with CMT2 do not show linkage with 1p markers, suggesting genetic heterogeneity in CMT2. We investigated linkage in a single large kindred with autosomal dominant CMT2. The gene responsible for CMT2 in this kindred (CMT2B) was mapped to the interval between the microsatellite markers D3S1769 and D3S1744 in the 3q13-22 region. Study of additional CMT2 kindreds should serve to further refine the disease gene region and may ultimately lead to the identification of a gene defect that underlies the CMT2 phenotype.