gebhart/patrepeval huggingface dataset:
Enzymatic methylation of cytosine in DNA is prevented by adjacent O6-methylguanine residues (1991)

The effect of O6-alkylation of guanine residues on the enzymic methylation of cytosine has been studied using synthetic oligonucleotides in which all guanines in cytosine-guanine sequences at potentially methylatable sites are replaced by O6-methylguanine. In contrast with the unmodified forms, which showed high acceptance activity for methyl-3H-labeled groups from S-adenosyl-L-[methyl-3H]methionine in the presence of DNA methylase, the modified oligonucleotides were not substrates for the enzyme either in the single-stranded or annealed forms. In view of the importance of cytosine methylation in the down-regulation of certain genes, the potential to affect gene expression by this mechanism may be a contributory factor in the toxic and carcinogenic effects of chemical methylating agents.
Reflection-in-Action and Business Undergraduates: What learning curve? (2003)

Scho¨n (1991, p. 9) says 'reflective practice in its own right (poses) a set of questions that researchers avoid at their own peril'. Such questions as 'what is it appropriate to reflect on? … What kinds of phenomena? … What is an appropriate way of observing and reflecting on practice? In what sort of activity does reflection consist …? How ought we to represent, in words or other symbols, our discoveries about practice …? By telling stories … explanatory models? … how shall we assess the consequences of our choices (of strategy for different purposes)? What constitutes appropriate rigour? how do we know what we claim to know?' He asks these questions on the back of his statement that 'there is nothing in the reflective turn (reflective on the understandings already built into the skillful actions of everyday practice) that requires a uniform approach to reflection'. So, no uniform approach? Questions we avoid at our peril? What chance then for undergraduate students, bound by the rigour of final level studies, where weakness in the art of reflection (in a core module) will have a major impact on their degree--and subsequent career--achievements? How should their tutor advise them with their reflective efforts, when there is realisation all round that the process is not easy, not always achieving of results, not--in these students' case--bound by the usual conventions for completing work for assessment?
ON THE OXIDATION OF Ni-23Co-17Cr-12AI-0.5Y-ALLOY SERVING AS BOND COAT IN THERMAL BARRIER COATINGS (2000)

Specimens of air plasma sprayed thermal barrier coatings with a Ni-23Co-17Cr-12Al-0.5Y bond coat have been oxidised in air at 900°C for 300-3000 hours. The oxide scale formed between the ceramic and the bond coat consists of essentially pure AI2O3, except at the interface with the ceramic overlay, where the composition of the oxide reflects that of the bond coat. The oxidation rate decreases with time and reflects growth of AI2O3, through inward grain boundary diffusion of oxygen. An inter-metallic phase identified as NiAl, precipitated during high temperature exposure. The thickness of the inter-metallic zone decreased with increasing oxidation duration. This was interpreted to reflect diffusion of Al toward the oxide and into the substrate. The amount of transient oxides at the surface was found to depend on the surface topography.
Short-Term Load Forecasting Based on an Adaptive Hybrid Method (2006)

This paper aims to develop a load forecasting method for short-term load forecasting, based on an adaptive two-stage hybrid network with self-organized map (SOM) and support vector machine (SVM). In the first stage, a SOM network is applied to cluster the input data set into several subsets in an unsupervised manner. Then, groups of 24 SVMs for the next day's load profile are used to fit the training data of each subset in the second stage in a supervised way. The proposed structure is robust with different data types and can deal well with the nonstationarity of load series. In particular, our method has the ability to adapt to different models automatically for the regular days and anomalous days at the same time. With the trained network, we can straightforwardly predict the next-day hourly electricity load. To confirm the effectiveness, the proposed model has been trained and tested on the data of the historical energy load from New York Independent System Operator.
Dielectric Behavior of Semifluorinated <i>n</i>-Alkane(F(CF<sub>2</sub>)<sub> <i>n</i> </sub>(CH<sub>2</sub>)<sub> <i>m</i> </sub>H) (1996)

Abstract Dielectric behavior of semifluorinated n-alkane F(CF2) n (CH2) m H, (n, m) = (10, 10), (12, 8) has been observed over ranges of frequency and temperature. The distribution parameter of dielectric relaxation time obtained from the Cole-Cole plot is nearly equal to unity. The apparent activation energies for F10H10 and Fl 2H8 are 134.6 kJ/mol and 65.8 kJ/mol, respectively, β-relaxation was observed which is associated with the rotation of the (CF2), group in semifluorinated n-alkane. The ratio of dipole moment, μ(F12H8)/μ(F10H10) obtained from the Fröhlich modification of Onsager's equation is 2.29, even though these compounds have the same constitution except for two carbons linking to the fluorine or hydrogen atoms. In addition we discuss the time dependence of the dielectric loss factor in the vicinity of phase transition temperatures.
The Crystal Structure of Prokaryotic Phospholipase A2 (2002)

In this study, the x-ray crystal structures of the calcium-free and calcium-bound forms of phospholipase A(2) (PLA(2)), produced extracellularly by Streptomyces violaceoruber, were determined by using the multiple isomorphous replacement and molecular replacement methods, respectively. The former and latter structures were refined to an R-factor of 18.8% at a 1.4-A resolution and an R-factor of 15.0% at a 1.6-A resolution, respectively. The overall structure of the prokaryotic PLA(2) exhibits a novel folding topology that demonstrates that it is completely distinct from those of eukaryotic PLA(2)s, which have been already determined by x-ray and NMR analyses. Furthermore, the coordination geometry of the calcium(II) ion apparently deviated from that of eukaryotic PLA(2)s. Regardless of the evolutionary divergence, the catalytic mechanism including the calcium(II) ion on secreted PLA(2) seems to be conserved between prokaryotic and eukaryotic cells. Demonstrating that the overall structure determined by x-ray analysis is almost the same as that determined by NMR analysis is useful to discuss the catalytic mechanism at the molecular level of the bacterial PLA(2).
Dielectric High-Power Bandpass Filter Using Quarter-Cut TE/018/ Image Resonator for Cellular Base Stations (1987)

A dielectric high-power bandpass filter using "quarter-cut TE/sub 01delta/ image resonators" has been developed. The resonator has a high unloaded Q over 7000 and its construction provides a sufficient thermal diffusion path to the metal housing. The insertion loss and the attenuation level of the eight-pole elliptic function type filter are 0.37 dB and 95 dB, respectively. The physical size of the dielectric filter is 280x135x 65 mm, one third to one fifth the volume of conventional cavity resonator filters.
Managing and Monitoring Statistical Models (2013)

Managing and monitoring statistical models can present formidable challenges when you have multiple models used by a team of analysts over time. How can you efficiently ensure that you’re always getting the best results from your models? In this paper, we’ll first examine these challenges and how they can affect your results. We’ll then look into solutions to those challenges, including lifecycle management and performance monitoring. Finally, we’ll look into implementing these solutions both with an in-house approach and with SAS ® Model Manager.
Bone‐Implant Interface Around Titanium Implants Under Different Loading Conditions: A Histomorphometrical Analysis in the Macaca fascicularis Monkey (2003)

Implant loading might have stimulated increased bone formation and thus may be a key factor in influencing positive osseointegration. In addition, immediately loaded implants may osseointegrate in a similar manner as delayed loaded implants.
Novel source-controlled self-verified programming for multilevel EEPROMs (2000)

In this work, a new source-controlled self-verified (SCSV) programming method for multilevel storage in EEPROM is discussed. Multilevel storage is a cost-effective approach to improve storage capacity and reduce bit-cost. However, the reduced interlevel margin impacts the reliability and available endurance. The new SCSV programming approach using simultaneous programming and verification can control threshold voltages by different source voltages. Linear relationship between threshold voltage and source voltage is obtained. Furthermore, the endurance of multilevel storage is extended up to 10/sup 6/ cycles. The accurate control of threshold voltage improves the reliability of multilevel EEPROM's. Therefore, the SCSV programming approach is a promising technique for future high-density and low-cost EEPROM applications.
Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis (1997)

Cross-linking of Fas (CD95) induces apoptosis, a response that has been reported to depend upon the Ras activation pathway. Since many examples of apoptosis have been reported to involve AP-1 and/or the AP-1-activation pathway. Since many examples of apoptosis have been reported to involve AP-1 and/or the AP-1-activating enzyme Jun kinase (JNK), downstream effectors of Ras or Ras-like small GTP-binding proteins, we evaluated the role of these molecules in Fas-mediated apoptosis. Although cross-linking of Fas on Jurkat T cells did result in JNK activation, increased activity was observed relatively late, being detectable only after 60 min of stimulation. Expression of a dominant negative form of SEK1 that blocked Fas-mediated induction of JNK activity had no effect on Fas-mediated apoptosis. Furthermore, maximally effective concentrations of anti-Fas did not cause JNK activation if apoptosis was blocked by a cysteine protease inhibitor, suggesting that under these conditions, activation of JNK may be secondary to the stress of apoptosis rather than a direct result of Fas engagement. Despite the activation of JNK, there was no induction of AP-1 activity as determined by gel shift assay or induction of an AP-1-responsive reporter. The lack of a requirement for AP-1 induction in Fas-mediated death was further substantiated with Jurkat cells that were stably transfected with a dominant negative cJun, TAM-67. While TAM-67 effectively prevented AP-1-dependent transcription of both the interleukin-2 and cJun genes, it had no effect on Fas-induced cell death, even at limiting levels of Fas signaling. Thus, induction of JNK activity in Jurkat cells by ligation of Fas at levels sufficient to cause cell death is likely a result, rather than a cause, of the apoptotic response, and AP-1 function is not required for Fas-induced apoptosis.
High efficiency envelope tracking supply voltage modulator for high power base station amplifier applications (2010)

Wideband supply voltage modulator with efficiency of 85.1% at 120 W average output power with 7.5 dB PAPR (Peak to average power ratio) (WCDMA, LTE, MC-GSM signals), and 91.7% at 130W output power with 0 dB PAPR (GSM applications), was built. Supply voltage modulator consists of a linear amplifier and a switching stage in parallel. The linear amplifier is controlled by an envelope signal, and a novel method for controlling the switching stage is presented, resulting in high efficiency and low sensitivity to component variations. Over 20%-unit efficiency improvement in back-off was achieved with the new control method. The measured efficiency was above 80% over 14 dB average power range with 7.5 dB PAPR test signal. Demonstrator circuit was built from discrete commercial components. An ET PA implemented with demonstrator modulator exhibited -60 dBc ACP linearity with dual carrier 7.5 dB PAPR WCDMA signal. For more wideband and compact ET PA implementation integrated circuit (IC) was fabricated and ET PA implemented with the IC modulator achieved -58 dBc ACP linearity with quad carrier 7.5 dB PAPR WCDMA signal. Wideband operation required special design for PA supply feed line design.
Insulin Receptor-mediated Dissociation of Grb2 from Sos Involves Phosphorylation of Sos by Kinase(s) Other than Extracellular Signal-regulated Kinase (1998)

The Ras signaling pathway is rapidly activated and then down-regulated following stimulation of multiple cell-surface receptors including the insulin receptor (IR). Much recent attention has focused on elucidating the mechanism of Ras inactivation following IR engagement. Previous data suggest that IR-mediated serine/threonine phosphorylation of the Ras guanine nucleotide exchange factor Sos correlates with its decreased affinity for the adapter protein Grb2. This phosphorylation-induced disassembly of the Grb2·Sos complex is thought to be responsible, at least in part, for diminishing Ras activity in Chinese hamster ovary cells. In this report, we confirm the causal relationship between Sos phosphorylation and Grb2/Sos dissociation. We then examine several putative phosphorylation sites of Sos that could potentially regulate this event. Since a number of reports suggest that extracellular signal-regulated kinase (ERK) phosphorylates Sos, we generated a Sos mutant lacking all seven canonical phosphorylation sites for ERK. This mutant is a poor substrate of activated ERK <i>in vitro</i> and fails to undergo a change in its electrophoretic mobility following IR stimulation. It is, however, phosphorylated after IR stimulation when expressed in Chinese hamster ovary cells. Interestingly, the mutant protein still dissociates from Grb2 following insulin stimulation, suggesting that ERK is not the kinase responsible for regulating the stability of the Grb2·Sos complex.
[123I]-Altropane SPECT (2007)

Positron emission tomography (PET) scan with [18F]-6-fluoro-dihydroxyphenylalanine (FDOPA) is currently the imaging “gold standard” for diagnosing Parkinson’s disease (PD), but this procedure is available at only a limited number of facilities. PET cameras are expensive, they require proximity to a cyclotron, and tests are nonreimbursable. A less costly and more available test, such as a single photon emission computed tomography (SPECT), may thus be helpful in the diagnosis of early or atypical PD, if its sensitivity is comparable with a PET scan. Altropane is an iodinated form of the N-allyl analog of WIN 35,428, which acts as a dopamine transport inhibitor. When radiolabeled with the γ-emitting isotope [123I], altropane serves as a SPECT ligand with high affinity and selectivity for the dopamine transporter. It is a good marker for dopamine neurons and is useful in detecting PD. There have now been reported cases that suggest altropane SPECT is comparable, if not possibly superior, to FDOPA PET scans in detecting early cases of PD.
The Coil Pump - Theory And Practice (1984)

An old idea for a simple pump has been developed and from laboratory investigations a theory has been produced which satisfactorily predicts the pump's behaviour. A low cost stream powered version of the pump was built and successfully tested in a local stream.
Upregulation of Long Non-Coding RNA DRAIC Correlates with Adverse Features of Breast Cancer (2018)

<i>DRAIC</i> (also known as <i>LOC145837</i> and <i>RP11-279F6.1</i>), is a long non-coding RNA associated with several types of cancer including prostate cancer, lung cancer, and breast cancer. Its expression is elevated in tumor tissues compared to adjacent benign tissues in breast cancer patients and is regulated by estrogen treatment in breast cancer cells. In addition, expression analysis of <i>DRAIC</i> in more than 100 cell lines showed that <i>DRAIC</i> expression is high in luminal and basal subtypes compared to claudin low subtype, suggesting a prognostic value of <i>DRAIC</i> expression in breast cancer. In the present study, we analyzed <i>DRAIC</i> expression in 828 invasive breast carcinomas and 105 normal samples of RNA sequencing datasets from The Cancer Genome Atlas (TCGA) and found that <i>DRAIC</i> expression was correlated with estrogen receptor (<i>ER</i>), progesterone receptor (<i>PR</i>), and human epidermal growth factor receptor 2 (<i>HER2</i>) status, and is increased in cancerous tissues. Additionally, higher <i>DRAIC</i> expression was associated with poorer survival of patients, especially in ER positive breast cancer. <i>DRAIC</i> was also investigated in the Oncomine database and we found that <i>DRAIC</i> expression predicted patients' response to paclitaxel and FEC as well as lapatinib, which are commonly used therapy options for breast cancer. Finally, <i>DRAIC</i> expression in breast cancer was negatively correlated with immune cell infiltration. These results reinforce the importance of <i>DRAIC</i> in breast cancer.
A Collaborative Evaluation of Seven Alternatives to the Draize Eye Irritation Test Using Pharmaceutical Intermediates (1995)

Much of the data which have been generated on in vitro alternatives to the Draize eye irritation test have dealt with compounds within a specific chemical class or product category. However, in the pharmaceutical industry, it is often necessary to evaluate materials which are not related in structure or properties. It was thus decided to evaluate a diverse series of chemicals in seven in vitro methods for estimating ocular irritation. Thirtyseven test materials were chosen to represent a broad range of pH, solubility, and in vivo irritation potential. Assays were chosen to include as many different types of end points as practical. The group of assays was composed of TOPKAT (assessing structure-activity relationships), bovine corneal opacity-permeability (BCO-P; corneal opacity/toxicity), Eytex (protein coagulation), neutral red uptake (cytotoxicity), MTT in living dermal equivalent (cytotoxicity), Microtox (cytotoxicity in bacteria), and CAMVA (inflammation/toxicity). The results of the study indicated that, in general, the cytotoxicity end points did not correlate well with the in vivo data. The BCO-P, CAMVA, and Eytex assays had the best overall concordance (88.9, 75.8, and 75.0%, respectively) with this set of compounds. Estimation of irritation potential based on structure-activity (TOPKAT) was possible for only approximately 50% of the compounds; however, the assay showed 100% sensitivity (i.e., no false negatives), but low specificity (i.e., negatives correctly identified only 54.5% of the time). These data suggest that for screening of chemicals of diverse structure and properties, the more mechanism-based assays, as opposed to general cytotoxicity assays, hold more promise and should be further evaluated.
The mechanism of enhancement in intestinal calcium absorption with phosphopeptides derived during casein digestion. (1986)

栄養素の過剰摂取が常に問題となっている現在, ミネラル, とくにCaと鉄の欠乏性が逆に顕在化している。この対策として, 食品に強化する方法は, かえって他のミネラルの利用性を妨げる心配がある。このようなことから, ミネラルの摂取量をふやさないで有効性を高めることが有利であると考えられる。CPPはその意味で一つの新しいアプローチの材料になるものであろう。すなわち食品タンパク質の難消化性ペプチドを探索して, ミネラルの吸収に有効なもの, または妨害する種類とそれらの性質を明らかにし, 食品の加工時, これらの効果を調節する可能性を示したもので, 食品栄養学上意義があるものと考えている。
Absolute measurement of surface and bulk absorption in DUV optics from temperature induced wavefront deformation (2010)

A measurement system for quantitative determination of both surface and bulk contributions to the photo-thermal absorption in DUV optics was developed. It is based upon a Hartmann-Shack wavefront sensor with a sensitivity of ~λ/10000 rms, accomplishing precise on-line monitoring of wavefront deformations of a collimated test laser beam transmitted perpendicular through the excimer laser-irradiated site of a cuboid sample. Caused by the temperature dependence of the refractive index as well as thermal expansion, the initially plane wavefront of the test laser is distorted into a cylindrical shape, with bending ends towards the surface. Sign and magnitude depend on index change and expansion. By comparison with thermal theory, this transient wavefront distortion yields a quantitative absolute measure of bulk and surface absorption losses in the sample. First rresults for fused silica are presented.
EXCITATION OF Hg+ 1942 Å IN THE HIGH-CURRENT—LOW-PRESSURE DISCHARGE (1971)

The intensity of the 1942-Å Hg+ ion resonance line in Hg-inert-gas discharges has been measured as a function of current density and Hg pressure in the range from 1 to about 15 A/cm2 and pressure from 10−3 to 0.5 Torr. In the Hg–Ar discharge the intensity of this line varies as the 1.75 power of the current density, while in Hg–Kr, the exponent is 2.0. There is evidence for volume recombination which is inhibited when Ar is replaced by Kr.
Electrochemistry and electron spin resonance of tetracyanoquinodimethane modified electrodes. Evidence for mixed-valence radical anions in the reduction process (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry and electron spin resonance of tetracyanoquinodimethane modified electrodes. Evidence for mixed-valence radical anions in the reduction processGyorgy Inzelt, Roger W. Day, James F. Kinstle, and James Q. ChambersCite this: J. Phys. Chem. 1983, 87, 23, 4592–4598Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/j100246a012https://doi.org/10.1021/j100246a012research-articleACS PublicationsRequest reuse permissionsArticle Views254Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A subpicosecond jitter PLL for clock generation in 0.12-μm digital CMOS (2003)

A fully integrated subpicosecond jitter phase-locked loop (PLL)-based frequency synthesizer in a standard digital 0.12-μm CMOS technology with 1.5-V supply is presented. Two differentially tuned LC-VCOs are implemented to support different standards for serial data transmission. A fully differential charge pump and an active loop filter are used for reduction of charge-pump current mismatch. Operating with a 311-MHz reference clock, the PLL achieves typically 860-fs integrated jitter, and a phase noise of -115 dBc/Hz at 1-MHz offset, on a 2.488-GHz output. The power consumption is 35 mW, and the area is 0.7 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .