gebhart/patrepeval huggingface dataset:
Incremental Kinematic Analysis of Mechanisms (1995)

Kinematic design is an important aspect of the design of mechanical systems with moving parts. The performance of such systems may suffer from the presence of parts that bind during their motion causing jams, or that execute undesired motions. Kinematic analysis needs to be conducted and the design of the system modified. Analysis-redesign-reanalysis cycles are common in reaching a satisfactory design. If the system is large and the incidence of redesign frequent, then it becomes imperative to have fast analysis methods. This work addresses this problem by providing computational techniques for doing incremental kinematic analysis. The mechanism is represented as a graph of objects with connection constraints among them. A recursive procedure traverses the graph to establish instantaneous kinematic properties. A store-and-reuse strategy is employed to increase the efficiency of re-analysis runs. This involves storing intermediate results of computations for reuse in case of incremental redesign or iterative analysis. The store-and reuse strategy is also applicable when retrieving elements of previous designs, and their associated kinematic analyses, and adapting them to new design problems. A comparative, quantitative study of the normal, “from-scratch” method and the incremental method is provided to prove the greater efficiency of the latter.
Characterization of the human α-synuclein gene: Genomic structure, transcription start site, promoter region and polymorphisms (2001)

The human NACP/alpha-synuclein gene has been cloned. This gene consists of 6 exons ranging in size from 42 to 1110 bp. The translation start codon ATG is encoded by exon 2 and the stop codon TAA is encoded by exon 6. The non-Abeta component of Alzheimer's disease amyloid (NAC) is encoded by exon 4. The two previously reported minor isoforms of NACP/alpha-synuclein, NACP112 [29] and NACP126 [6], are alternatively spliced products, in which exon 5 and exon 3 are spliced out, respectively. Exon 1 was found to have different splicing sites, producing different 5'-untranslated sequences in the cDNAs. A previously reported dinucleotide repeat polymorphic marker has been mapped to 8kb upstream of the transcription start site. A highly TC-rich sequence in intron 4 was found to be polymorphic by length and four alleles, A0, A1, A2 and B have been identified in the Caucasian population. Genotyping this polymorphism among pure Alzheimer's, Lewy body variant and Parkinson's subjects and aged normal control subjects did not reveal any significant differences.
Predicting enterprise cyber incidents using social network analysis on the darkweb hacker forums (2018)

With rise in security breaches over the past few years, there has been an increasing need to mine insights from social media platforms to raise alerts of possible attacks in an attempt to defend conflict during competition. We use information from the darkweb forums by leveraging the reply network structure of user interactions with the goal of predicting enterprise cyber attacks. We use a suite of social network features on top of supervised learning models and validate them on a binary classification problem that attempts to predict whether there would be an attack on any given day for an organization. We conclude from our experiments using information from 53 forums in the darkweb over a span of 12 months to predict real world organization cyber attacks of 2 different security events that analyzing the path structure between groups of users is better than just studying network centralities like Pagerank or relying on the user posting statistics in the forums.
Quantitative Trait Loci for Tomato Yellow Leaf Curl Virus and Tomato Mottle Virus Resistance in Tomato (2006)

The genetic basis of resistance to tomato yellow leaf curl virus (TYLCV) and tomato mottle virus (ToMoV) was studied in three different mapping populations of tomato ( Lycopersicon esculentum Mill.). Bulked segregant analysis (BSA) was used to identify random amplification of polymorphic DNA (RAPD) markers linked to TYLCV and ToMoV resistance. Segregated RAPD markers associated with resistance were linked to morphological markers self-pruning ( sp ) and potato leaf ( c ) on chromosome 6. RAPD genetic linkage maps of chromosome 6 were constructed for each of the three populations. Common mapped markers revealed straightforward homologies between the chromosome 6 linkage group of the three populations. Multiple-QTL mapping (MQM) was used to identify quantitative trait loci (QTL) for resistance linked to chromosome 6. These revealed that the resistance against TYLCV and ToMoV was mainly explained by two QTL in two populations and one QTL in another. For all of the resistance QTL detected, the favorable allele was provided by the resistant parents. The presence of three different sources of TYLCV and ToMoV resistance, and the markers in tight linkage with them, provide a means of systemically combining multiple resistance genes. Successful cloning of the R gene from tomatoes would lead to deeper understanding of the molecular basis of resistance to TYLCV and ToMoV, and might also shed light on the evolution of resistance genes in plants in general.
Allergic Contact Dermatitis Caused by Zinc Pyrithione Associated With Pustular Psoriasis (1997)

A case of allergic contact dermatitis to a shampoo containing zinc pyrithione associated with an eruption of pustular psoriasis is reported. The patient had had stable psoriasis for 5 years, and never any other skin disease. Within 1 week, she developed severe generalized pustular psoriasis with many lesions where the shampoo was applied. Treatment with cyclosporin, 200 to 300 mg daily, cleared the eruption within 4 weeks, except for psoriasis of the scalp. Extensive patch testing revealed a relevant sensitization to zinc pyrithione. This case illustrates that a generalized pustular psoriasis can be provoked by a substance present in a hair shampoo. Short-term treatment with cyclosporin is valuable in exacerbations of psoriasis caused by allergic contact dermatitis.
Induction of Suicidal Erythrocyte Death by Listeriolysin from <i>Listeria monocytogenes</i> (2007)

Listeriolysin, the secreted cytolysin of the facultative intracellular bacterium Listeria monocytogenes, is its major virulence factor. Previously, non-lytic concentrations of listeriolysin were shown to induce Ca2+-permeable nonselective cation channels in human embryonic kidney cells. In erythrocytes, Ca2+ entry is followed by activation of K+ channels resulting in K+-exit as well as by membrane scrambling resulting in phosphatidylserine exposure at the cell surface. Phosphatidylserine-exposing erythrocytes are recognized by macrophages, engulfed, degraded and thus cleared from circulating blood. Phosphatidylserine exposure is a key event of eryptosis, the suicidal death of erythrocytes. The present study utilized patch-clamp technique, Fluo3-fluorescence, and annexin V-binding in FACS analysis to determine the effect of listeriolysin on cell membrane conductance, cytosolic free Ca2+ concentration, and phosphatidylserine exposure, respectively. Within 30 minutes, exposure of human peripheral blood erythrocytes to low concentrations of listeriolysin (which were non-hemolytic for the majority of cells) induced a Ca2+-permeable cation conductance in the erythrocyte cell membrane, increased cytosolic Ca2+ concentration, and triggered annexin V-binding. Increase of extracellular K+ concentration blunted, but did not prevent, listeriolysin-induced annexin V-binding. In conclusion, listeriolysin triggers suicidal death of erythrocytes, an effect at least partially due to depletion of intracellular K+. Listeriolysin induced suicidal erythrocyte death could well contribute to the pathophysiology of L. monocytogenes infection.
Enkele infraspecifieke taxa bij Ranunculus ficaria L (1966)

The author draws attention to two forms of Ranunculus ficaria L., one with axillary bulbils and a small number of well-developed achenes, the other with no axillary bulbils and many welldeveloped achenes. Only the former is up till now known from the Netherlands.
Efficient Approach To Design Stable Water-Dispersible Nanoparticles of Hydrophobic Cellulose Esters (2008)

Commercially prepared cellulose acetate, cellulose acetate propionate, -butyrate, and -phthalate as well as cellulose acetates prepared in the laboratory scale with varying degree of substitution (DS) self-assemble into regular nanoparticles, ranging in size from 86 to 368 nm, by using two different techniques of nanoprecipitation. Dialysis of polymers dissolved in N,N-dimethylacetamide results in the formation of regular nanospheres whereas the preparation in acetone by successive adding of water leads to bean-shaped particles in the nanoscale. One criterion for nanoprecipitation is the existence of dilute polymer solutions. Furthermore, the formation of nanoparticles strongly depends on DS and distribution of the substituents. Concerning this issue, quantitative (13)C NMR spectroscopy was applied for detailed structure characterization of selected cellulose acetates. The stability of the nanoparticle suspensions in the physiological pH range was observed by zeta potential measurements.
Phase I Trial of ImmTher, a New Liposome-Incorporated Lipophilic Disaccharide Tripeptide (1991)

A phase I clinical trial was conducted to evaluate the toxicology and biological activity of a new liposome-incorporated lipophilic disaccharide tripeptide, ImmTher. Twelve patients with advanced nonhematological malignant disease received 13 courses of therapy at dose levels of 200-1,200 micrograms/m2. A course of therapy consisted of once-weekly administration of the drug for 2-12 weeks. The major clinical toxicities observed were chills and hypotension. No renal, hepatic, cardiac, or hematological toxicity was observed. A small decrease in pulmonary diffusion capacity was observed. Biological activity was demonstrated by changes in plasma cytokine levels, changes in in vitro monocyte cytotoxicity, and by a decrease in tumor size. Improvement was observed in three of three patients with metastatic disease to the liver. Response in these three patients correlated with an increase in their tumor necrosis factor and neopterin levels compared with nonresponders. These preliminary indications of biological and clinical activity of a liposome-incorporated lipophilic disaccharide tripeptide in patients with advanced metastatic hepatic disease suggest a potential new therapeutic approach to this common problem.
Automatic multi channel serial I/O interface using FPGA (2011)

The Digital input and output signal interface (DIO) is an important component for a machine wanted to be interacted with its environment. Although a main processing unit (MPU) used in the machine has its own DIO channel, for some cases, the machine needs to use more DIO channel than those the MPU can provide. To avoid this problem, a DIO board interfaced directly to the MPU via serial communication is designed. If the MPU connect to multiple DIO boards directly, it will waste sometime to process of communication data, for example processing time is check ready to receive or sending signals. To reduce the unnecessary processing time of the MPU and possibility to have many DIO boards connected, a serial interface unit based on FPGA is developed to help the MPU to communicate with DIO boards. The FPGA unit automatically reads serial signals from each DIO boards and save interpreted data to share registers for MPU to read. The FPGA unit also spontaneously reads registers written by MPU and send registers values to DIO boards automatically. The FPGA unit is XC3S400–4PQ208 chip programmed by VHDL language and has been tested with 3 DIO boards simultaneously. The experiment result shows that the FPGA unit is able to receive and send data between the MPU and DIO boards.
Hereditary hemochromatosis in a patient with congenital dyserythropoietic anemia (2000)

Herein is described the case of a young woman presenting with iron overload and macrocytosis. The initial diagnosis was hereditary hemochromatosis. Severe anemia developed after a few phlebotomies, and she was also found to have congenital dyserythropoietic anemia that, though not completely typical, resembled type II. Only genetic testing allowed the definition of the coexistence of the 2 diseases, both responsible for the iron overload. This report points out the need to consider congenital dyserythropoietic anemia in patients with hemochromatosis and unexplained macrocytosis and, conversely, to check for the presence of hereditary hemochromatosis in patients with congenital dyserythropoietic anemia and severe iron overload. To the authors' knowledge, this is the first report of homozygosity for the C282Y mutation of the HFE gene in a patient affected by congenital dyserythropoietic anemia.
GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET (2009)

The mouse gamma-aminobutyric acid (GABA) transporter mGAT1 was expressed in neuroblastoma 2a cells. 19 mGAT1 designs incorporating fluorescent proteins were functionally characterized by [(3)H]GABA uptake in assays that responded to several experimental variables, including the mutations and pharmacological manipulation of the cytoskeleton. Oligomerization and subsequent trafficking of mGAT1 were studied in several subcellular regions of live cells using localized fluorescence, acceptor photobleach Förster resonance energy transfer (FRET), and pixel-by-pixel analysis of normalized FRET (NFRET) images. Nine constructs were functionally indistinguishable from wild-type mGAT1 and provided information about normal mGAT1 assembly and trafficking. The remainder had compromised [(3)H]GABA uptake due to observable oligomerization and/or trafficking deficits; the data help to determine regions of mGAT1 sequence involved in these processes. Acceptor photobleach FRET detected mGAT1 oligomerization, but richer information was obtained from analyzing the distribution of all-pixel NFRET amplitudes. We also analyzed such distributions restricted to cellular subregions. Distributions were fit to either two or three Gaussian components. Two of the components, present for all mGAT1 constructs that oligomerized, may represent dimers and high-order oligomers (probably tetramers), respectively. Only wild-type functioning constructs displayed three components; the additional component apparently had the highest mean NFRET amplitude. Near the cell periphery, wild-type functioning constructs displayed the highest NFRET. In this subregion, the highest NFRET component represented approximately 30% of all pixels, similar to the percentage of mGAT1 from the acutely recycling pool resident in the plasma membrane in the basal state. Blocking the mGAT1 C terminus postsynaptic density 95/discs large/zona occludens 1 (PDZ)-interacting domain abolished the highest amplitude component from the NFRET distributions. Disrupting the actin cytoskeleton in cells expressing wild-type functioning transporters moved the highest amplitude component from the cell periphery to perinuclear regions. Thus, pixel-by-pixel NFRET analysis resolved three distinct forms of GAT1: dimers, high-order oligomers, and transporters associated via PDZ-mediated interactions with the actin cytoskeleton and/or with the exocyst.
Optimization of Non-Local Means filtration for Cone Beam Computed Tomography (2015)

Cone Beam Computed Tomography (CBCT) is a medical imaging technique used to\nvisualize the internals of an object from a set of X-ray images. The X-ray images are\ntaken with a cone shaped X-ray beam at many angles around the object being visualized.\nThe images are then back projected through a volume forming a 3D representation of\nthe object.\nNon-local means (NLM) denoising was applied to the X-ray images before they were\nused in the back projection algorithm. NLM was implemented for the graphics card\nand runs in real time while the X-ray images are taken. Compared to current denoising\nmethods the result was less noisy and had higher sharpness.\nIt was found that using NLM on the X-ray images led to streak artifacts and smearing\nof fine details in the reconstructed volume. Many versions of NLM were tested to reduce\nthese effects, including variance reduction, total variation and using adjacent images in\nthe scan. The different versions however gave very similar results. The state-of-the-art\ndenoising algorithm BM3D was also tested for reference and the results were very similar\nto NLM.\nNLM denoising in the reconstructed volume as a post-processing step was also tested\nwhich showed improved results over denoising the projection images. Denoising in 3D\nled to less artifacts and better preservation of details. The runtime for the 3D-denoising\nis only a few seconds on the graphics card, making it useful in practice.\n3D-NLM denoising offers the possibility of lowering the radiation dose to the patient\nsince the noise can be reduced while keeping edges and details intact. The noise can\nbe reduced such that a low dose scan is comparable to a high dose scan denoised with\ncurrent CBCT denoising methods. A comparison of spatial resolution and preservation\nof details indicates that the dose could be lowered by as much as half without significantly\nlowering the image quality.
ADMS-automatic device model synthesizer (2003)

This paper presents ADMS, a new open-source tool that supports automatic synthesis of compact models into circuit simulators. ADMS takes as input Verilog-AMS compact model descriptions and generates C code that conforms to circuit simulator interfaces. ADMS supports the simulators Mica, Spectre, and HSIM, and has been used to implement the SP and SSIM MOSFET models, the VBIC BJT model, and the R3 resistor model, the last two including self-heating.
Dengue-1 Virus Envelope Glycoprotein Gene Expressed in Recombinant Baculovirus Elicits Virus-Neutralizing Antibody in Mice and Protects them from Virus Challenge (1991)

In order to test the feasibility of baculovirus (Autographa californica nuclear polyhedrosis virus, AcNPV) expression vectors for making immunogens against dengue-1 (DEN-1) virus, a portion of the envelope (E) glycoprotein gene of DEN-1 virus was cloned and expressed. The recombinant baculovirus contains 107 nucleotides from the 3' terminus of the DEN-1 matrix (M) gene, which encodes a hydrophobic signal peptide and extends through the first 1, 245 nucleotides of E, terminating 243 nucleotides before the 3' terminus of E. When the recombinant virus was grown in Spodoptera frugiperda cells, about 1 mg of E antigen was made per 10(9) cells. Recombinant E antigen reacted with E protein-specific monoclonal antibodies and stimulated production of DEN-1 virus neutralizing antibody in BALB/c mice. Mice immunized with recombinant E antigen or with heat-inactivated DEN-1 virus were protected significantly against lethal DEN-1 virus challenge. A dose/response effect was observed, with increasing amounts of recombinant antigen leading to increased survival. These results demonstrate the utility of baculovirus for producing immunogens against DEN-1 virus.
A comparison of foliar nutrient concentration in trees from monsoon rainforest and savanna in northern Australia (1995)

Abstract Analysis of foliar nutrient concentrations revealed that two mesophyllic monsoon rainforest trees had higher concentrations of most nutrients in leaves than eight savanna species. One of the tested monsoon rainforest species with sclerophyllous leaves had similar nutrient concentrations to the savanna tree species. There were positive or no significant correlations between live foliar nutrient concentration and the percentage of nutrients withdrawn prior to litterfall. The nutrient concentration of litter was similar for most nutrients among tree species of monsoon rainforest or savanna. The results of this study suggest that the relative fertility of surface soils of monsoon rainforest compared with savanna is not determined by contrasting nutrient cycling strategies whereby monsoon rainforest tree species enrich their soils with relatively nutrient rich leaf litter relative to savanna tree species.
Supersensitivity to light: possible trait marker for manic-depressive illness (1985)

Exposure to light during the night reduces plasma melatonin levels. A previous study showed that, in response to light, nighttime plasma melatonin levels fell twice as much in a group of acutely ill manic-depressive patients as in a group of normal subjects. The present study compares 11 euthymic manic-depressive patients not taking medications with 24 age- and sex-matched normal subjects. Melatonin levels in these patients also fell twice as much as the levels of the normal subjects, suggesting that supersensitivity to light may be a trait marker for bipolar affective disorder.
On calculating ionospheric conductances from the flux and energy of precipitating electrons (1987)

Auroral zone conductances can be estimated from the energy flux and average energy of precipitating electrons. These estimates are based on the assumption that the conductances produced by the electrons are very similar to those produced by electrons with Maxwellian energy distributions having the same energy flux and average energy. There has been some confusion in the application of this method because for a Maxwellian the average energy is twice the characteristic energy or temperature. We present revised expressions that relate height‐integrated Hall and Pedersen conductance to the flux and average energy of a Maxwellian. We show that the accuracy of this method depends on the minimum and maximum energy within which the distribution is integrated to get the energy flux and average energy. We also confirm that the conductances produced by some of the more common auroral spectral distributions are similar to those produced by a Maxwellian with the same average energy and energy flux. The application of these results is demonstrated using precipitating electron measurements made by the Hilat satellite during a pass over Greenland.