gebhart/patrepeval huggingface dataset:
Characterization of devA, a gene required for the maturation of proheterocysts in the cyanobacterium Anabaena sp. strain PCC 7120 (1994)

Mutant M7, obtained by transposon mutagenesis of the cyanobacterium Anabaena sp. strain PCC 7120, is impaired in the development of mature heterocysts. Under aerobic conditions, the mutant is unable to fix N2 because of a deficiency of at least two components of the oxygen-protective mechanisms: a hemoprotein-coupled oxidative reaction and heterocyst-specific glycolipids. DNA contiguous with the inserted transposon was recovered from the mutant and sequenced. The transposon had inserted itself within a 732-bp open reading frame designated devA. The wild-type form of devA, obtained from a lambda-EMBL3 library of Anabaena sp. DNA, had the identical sequence. Directed mutagenesis of devA in the wild-type strain showed that the phenotype of the mutant was caused by insertion of the transposon. The wild-type form of devA on a shuttle vector complemented the mutation in M7. Expression of devA by whole filaments, monitored following nitrogen stepdown by using luxAB as the reporter, increased ca. eightfold during differentiation; the increase within differentiating cells was much greater. The deduced sequence of the DevA protein shows strong similarity to the ATP-binding subunit of binding protein-dependent transport systems. The product of devA may, therefore, be a component of a periplasmic permease that is required for the transition from a proheterocyst to a mature, nitrogen-fixing heterocyst.
MgO epitaxial thin films on (100) GaAs as a substrate for the growth of oriented PbTiO3 (1992)

Epitaxial MgO thin films were grown on (100) GaAs substrates by reactive rf magnetron sputtering. Coupled x-ray diffraction, off-axis φ scan, and transmission electron microscopy indicated in-plane alignment of the MgO film with the GaAs substrate such that MgO[100]∥GaAs[100]. PbTiO3 ferroelectric thin films, grown on this MgO surface, were found to be oriented with PbTiO3{100}∥ MgO(001)∥ GaAs(001) and PbTiO3〈100〉∥ MgO[100]∥ GaAs[100].
Synthesis of Thieno[2,3-b]thiophene Containing Bis-Heterocycles-Novel Pharmacophores (2013)

Thioenethiophene derivatives represent an important class of compounds with diverse biological activities. We describe here the synthesis of a new series of thieno[2,3-b]thiophene containing bis-heterocyclic compounds 3-7. All the compounds were evaluated for their in vitro antioxidant potential, α-glucosidase and β-glucuronidase inhibiton and anticancer activity against PC-3 cell lines. Compounds 2b (IC50 = 1.3 ± 0.2 μM), 5a (IC50 = 2.3 ± 0.4 μM) and 5b (IC50 = 8.7 ± 0.1 μM) showed a potent inhibition of β-glucuronidase enzyme, more active than the standard d-saccharic acid 1,4-lactone (IC50 = 45.8 ± 2.5 μM). Compounds 5a (IC50 = 22.0 ± 0.3 μM) and 5b (IC50 = 58.4 ± 1.2 μM) were also found to be potent α-glucosidase inhibitors as compared to standard drug (acarbose, IC50 = 841 ± 1.7 μM).
Evaporative self-assembly of nanowires on superhydrophobic surfaces of nanotip latching structures (2011)

In this letter, we report a site-specific self-assembly of nanowires during the evaporation of a colloid droplet of nanowires on nanoengineered superhydrophobic surfaces. The self-assembly of nanowires is achieved by the interactions between nanowires and the superhydrophobic surface engineered with sharp-tip latching nanostructures of micropillars, provided by the convective hydrodynamic flow and the receding three-phase contact line of the evaporating droplet. The experimental results show that the spatial density of surface structures, the relative dimension of surface patterns to nanowires, and the morphology of tip surface influence the self-assembly and alignment of nanowires on the evaporative superhydrophobic surface.
Correlation of 16S Ribosomal DNA Signature Sequences with Temperature-Dependent Growth Rates of Mesophilic and Psychrotolerant Strains of the <i>Bacillus cereus</i> Group (1999)

Sequences of the 16S ribosomal DNA (rDNA) from psychrotolerant and mesophilic strains of the Bacillus cereus group revealed signatures which were specific for these two thermal groups of bacteria. Further analysis of the genomic DNA from a wide range of food and soil isolates showed that B. cereus group strains have between 6 and 10 copies of 16S rDNA. Moreover, a number of these environmental strains have both rDNA operons with psychrotolerant signatures and rDNA operons with mesophilic signatures. The ability of these isolates to grow at low temperatures correlates with the prevalence of rDNA operons with psychrotolerant signatures, indicating specific nucleotides within the 16S rRNA to play a role in psychrotolerance.
Spectral discrimination of Čerenkov radiation in scintillating dosimeters (2005)

Radiation therapy accelerators require highly accurate dose deposition and the output must be monitored frequently and regularly. Ionization chambers are the primary tool for this control, but their size, their high voltage needed, and the correction needed for electrons make them unsuitable for use during patient treatment. We have developed a small (1-mm-diam and 1-mm-long active part), flexible, and water-equivalent dosimeter. It is suitable for photon and electron beams without corrections, and performs on line dose measurements. This detector is based on only one scintillating fiber and a CCD camera. A new signal processing is used to remove the effect of Cerenkov radiation background, which only requires a preliminary calibration. Central-axis depth-dose distribution comparisons have been achieved with standard ionization chambers, over a range from 8 to 25 MV photons and from 6 to 21 MeV electrons in order to validate this calibration. Results show a very good agreement, with less than 1% difference between the two detectors.
Phenotypic and cytogenetic characterization of a cell line derived from primary prostatic carcinoma (1989)

A new cell line, PPC-I, has been established from a specimen obtained from a patient with a poorly differentiated adenocarcinoma of the prostate. This is the first line of its type derived from a primary prostatic tumor site. PPC-I cells have become immortalized in culture, exhibit transformation parameters including relaxed growth factor requirements and anchorage-independent growth, and are highly tumorigenic in nude mice. Cytogenetic studies by G-banding revealed a grossly abnormal karyotype, with a modal chromosome number of 84, multiple marker chromosomes including both homogeneously staining regions and double minutes and clonal loss of chromosomes 3, 5, 10, 15 and Y.
PHYSICAL ACTIVITY, DIET, AND RISK OF COLON CANCER IN UTAH (1988)

A population-based case-control study was used to assess the relations of physical activity and diet to the development of colon cancer in Utah. Data were obtained for a reference period of two years prior to interview for controls (204 females and 180 males) and two years prior to the date of diagnosis for cases (119 females and 110 males). Both leisure time and occupational activities were ascertained by level of intensity and were converted to calories expended per week for analysis. Dietary data were obtained from a quantitative food frequency questionnaire. Physical activity and dietary data were divided into quartiles based upon the distribution in the study population for analyses. Total physical activity was protective against the development of colon cancer for both males (odds ratio (OR) = 0.70) and females (OR = 0.48) when high and low quartiles of activity were compared. Intense physical activity was the component of activity that had the greatest protective effect for males (OR = 0.27); a similar relation was seen for females (OR = 0.55). The observed relation between physical activity and colon cancer was not confounded by dietary intake of calories, fat, or protein, nor was the diet and colon cancer relation confounded by physical activity (odds ratios for calories, protein, and fat in males were 2.40, 2.57, and 2.18, respectively). Assessment of the interrelations among physical activity, diet, and colon cancer suggests that physical activity modifies colon cancer risk associated with diet.
Effect of misoprostol on serum (βM2-microglobulin in the course of viral hepatitis B (1999)

These data confirm the beneficial effect of misoprostol treatment in patients with viral hepatitis B. A possible mechanism of action seems to be its effect on serum concentration of beta2-m, related to antigen presentation on the hepatocyte surface.
NMR solution structure of the antifungal protein from Aspergillus giganteus: evidence for cysteine pairing isomerism (1995)

The solution structure of the antifungal protein (AFP, 51 residues, 4 disulfide bridges) from Aspergillus giganteus has been determined by using experimentally derived interproton distance constraints from nuclear magnetic resonance (NMR) spectroscopy. Complete sequence-specific proton assignments were obtained at pH 5.0 and 35 degrees C. A set of 834 upper limit distance constraints from nuclear Overhauser effect measurements was used as input for the calculation of structures with the program DIANA. An initial family of 40 structures calculated with no disulfide constraints was used to obtain information about the disulfide connectivities, which could not be determined by standard biochemical methods. Three possible disulfide patterns were selected and the corresponding disulfide constraints applied to generate a family of 20 DIANA conformers for each pattern. Following energy minimization, the average pairwise RMSD of the 20 conformers of each family is 1.01, 0.89, and 1.01 A for backbone atoms and 1.82, 1.74, and 1.81 A for all heavy atoms. One of these three families contains the disulfide bridge arrangement actually present in the solution structure of AFP. Although the three families fulfill the NMR constraints, one of the disulfide patterns considered (cysteine pairs 7-33, 14-40, 26-49, 28-51) is favored among the others on the basis of previous chemical studies. It thus probably corresponds to the actual pattern of disulfide bridges present in the protein, and the corresponding family represents the solution structure of AFP. The folding of AFP consists of five antiparallel beta strands connected in a -1, -1, +3, +1 topology and highly twisted, defining a small and compact beta barrel stabilized by four internal disulfide bridges. A cationic site formed by up to three lysine side chains adjacent to a hydrophobic stretch, both at the protein surface, may constitute a potential binding site for phospholipids which would be the basis of its biological function. On the other hand, a second, minor form of AFP has been detected. NMR data, together with results from mass spectrometry, chemical analysis, and sedimentation equilibrium, suggest that this species differs from the major form in the pairs of cysteines involved in the four disulfide bridges.
Storage Stability of Butterfish Mince (<i>Peprilus buri</i>) as Affected by Washing, Antioxidants, and Vacuum Packaging (1996)

Gulf of Mexico butterfish (Peprilus buri), a largely unutilized fishery resource, has been examined for its application as a food-grade marine product. Butterfish mince prewashed with sodium bicarbonate solution (0.5%) had lower lipid oxidation and free fatty acid (FFA) content than unwashed mince during a 6-month frozen storage study. Washed mince also exhibited a lower Hunter a value and had superior water retention. Addition of Tenox 2 or vacuum packaging further reduced lipid oxidation and FFA liberation. This reduction also prevented the subsequent lipid-protein interaction as indicated by increased water retention.
Insight from a Docker Container Introspection (2019)

Large-scale adoption of virtual containers has stimulated concerns by practitioners and academics about the viability of data acquisition and reliability due to the decreasing window to gather relevant data points. These concerns prompted the idea that introspection tools, which are able to acquire data from a system as it is running, can be utilized as both an early warning system to protect that system and as a data capture system that collects data that would be valuable from a digital forensic perspective. An exploratory case study was conducted utilizing a Docker engine and Prometheus as the introspection tool. The research contribution of this research is two-fold. First, it provides empirical support for the idea that introspection tools can be utilized to ascertain differences between pristine and infected containers. Second, it provides the ground work for future research conducting an analysis of large-scale containerized applications in a virtual cloud.
Mono- and bisdiazotization of proflavine (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMono- and bisdiazotization of proflavineWilliam Firth III and Lerena W. YieldingCite this: J. Org. Chem. 1982, 47, 15, 3002–3004Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/jo00136a039https://doi.org/10.1021/jo00136a039research-articleACS PublicationsRequest reuse permissionsArticle Views150Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A model predictive control-based approach for spacecraft formation keeping and attitude control (1999)

In this paper we report on the application of a model predictive control-based approach to the design of a controller for formation keeping and formation attitude control, with applications to spacecraft formation flight problems such as NASA's DS3 mission. Control laws for formation keeping and attitude control are designed using a combined approach of feedback linearization and model predictive control. Actuator saturation is incorporated into the controller design. Switching between coordinated frames is incorporated to overcome singularities associated with local feedback linearization.
Synthetic Studies on Cyclopentane Derivatives (1971)

A new synthetic route to prostaglandin-F1 skeleton from readily accessible 2-carboxy-hexyl-cyclopentane-1, 3, 4-trione was achieved. The route included 2-alkyl-3-cyano-4-hydroxy-2-cyclopenten-l-one as an intermediate.
Lightweight portable sensors for health care (2010)

In this article, textile electrodes and semiconductor thin film piezoresistive sensors on plastic substrates were manufactured and fabricated with CMOS processes, respectively. An armband made of plain weave fabric, integrating embroidery textile electrodes of stainless steel (SS) and elastics to conform to human forearms were manufactured. The textile electrodes with an area of 1cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> were made of two stitching layers for ease of manufacture and electrode robustness and connected through snap fasteners and SS/cotton threads to a signal processing electronic module. Piezoresistive sensors, consisting of n-type hydrogenated nanocrystalline silicon thin films patterned into rectangular bars and having metallic thin leads connecting the sensor to large pads were fabricated on 25μm thick flexible (polyimide) substrates. The textile and thin film piezoresistive sensors were connected to a small lightweight signal processing electronic module of a wireless portable unit for real-time monitoring and recording of the sensors signals. Surface electromyography signals of the forearms of a volunteer wearing the armband with textile electrodes exhibit amplitudes and baseline noise levels comparable to those obtained with standard Ag/AgCl electrodes. The piezoresistive sensor on plastic substrate was stuck with grease to the neck of a volunteer and small front/back neck movement monitored and recorded.
Crystal structure of the <i>Streptococcus pneumoniae</i> mevalonate kinase in complex with diphosphomevalonate (2007)

Streptococcus pneumoniae, a ubiquitous gram-positive pathogen with an alarming, steadily evolving resistance to frontline antimicrobials, poses a severe global health threat both in the community and in the clinic. The recent discovery that diphosphomevalonate (DPM), an essential intermediate in the isoprenoid biosynthetic pathway, potently and allosterically inhibits S. pneumoniae mevalonate kinase (SpMK) without affecting the human isozyme established a new target and lead compound for antimicrobial design. Here we present the crystal structure of the first S. pneumoniae mevalonate kinase, at a resolution of 2.5 A and in complex with DPM.Mg(2+) in the active-site cleft. Structural comparison of SpMK with other members of the GHMP kinase family reveals that DPM functions as a partial bisubstrate analog (mevalonate linked to the pyrophosphoryl moiety of ATP) in that it elicits a ternary-complexlike form of the enzyme, except for localized disordering in a region that would otherwise interact with the missing portion of the nucleotide. Features of the SpMK-binding pockets are discussed in the context of established mechanistic findings and inherited human diseases linked to MK deficiency.
Using difficulty of prediction to decrease computation: fast sort, priority queue and convex hull on entropy bounded inputs (2002)

Studies have indicated that sorting comprises about 20% of all computing on mainframes. Perhaps the largest use of sorting in computing (particularly business computing) is the sort required for large database operations (e.g. required by joint operations). In these applications the keys are many words long. Since our sorting algorithm hashes the key (rather than compare entire keys as in comparison sorts such as quicksort), our algorithm is even more advantageous in the case of large key lengths; in that case the cutoff is much lower. In case that the compression ratio is high, which can be determined after building the dictionary, we just adopt the previous sorting algorithm, e.g. quick sort. The same techniques can be extended to other problems (e.g. computational geometry problems) to decrease computation by learning the distribution of the inputs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Combining Production History and Petrophysical Correlations to Obtain Representative Relative Permeability Data (1983)

ABSTRACT Prediction of gas reservoir performance under water drive is very sensitive to relative permeability data. Gas-water relative permeability ratio (Kg/Kw) at different values of water saturation (Sw) can be derived from production history. This technique provides data considered the most representative of reservoir characteristics since it reflects actual reservoir performance. However, the developed (Kg/Kw) vs Sw curve is only valid in the higher range of water saturation and in the absence of water coning and other forms of water intrusion. The valid portion of the curve can be used to calibrate a generalized correlation. The calibrated correlation is then used to derive relative permeability data over the entire water saturation range. The technique discussed can also be applied to oil-water systems.
Design and Test of Saturable Reactor (2012)

With the expansion of the grid, continuous reactive power compensation is vital for efficient operation of long transmission power lines or cables. Yunnan Electric Power Grid is planning to development saturable reactors for 500 kV long distance AC transmission lines. As the first stage of the development plan, the appropriate saturable reactor structure should be presented and verified by experiment. In this paper, different ferromagnetic materials, core structures and winding arrangements of saturable reactors are analyzed. Then, appropriate saturable reactor structure is determined by simulating calculation. Based on that, a small-scale prototype is designed and fabricated. The experimental results show that it can obtain a continuous controllable reactive power output.
An interactive digital television system designed for synchronised and scalable multi-media content over DVB and IP networks (2005)

Although some market research has predicted the rapid uptake of digital television by European householders, recent unsettling experiences in the UK digital television market has shown that consumers demand a more value added viewing experience. This is understood by the fact that terrestrial analogue broadcasting has enjoyed a reputation of providing a television service to a very high standard. It is thus necessary to find ways in which end-users can best exploit the increased flexibility and the advantages that digital television creates. For this to happen, the whole value of the broadcasting chain has to support seamless integration of the broadcast and telecommunication networks. The European Union IST project, SAVANT (synchronised and scalable AV content across networks), aims to provide an interactive digital framework for scalable broadcast television services converged with television oriented IP services. The paper describes the major architectural components of the project.
Overview of N-(phosphonacetyl)-L-aspartate + fluorouracil in clinical trials. (1992)

The clearest example of successful biochemical modulation of cancer chemotherapy in the laboratory, followed by initial failure to reproduce successful therapeutic results in the clinic, and then eventually followed by clinical success, is that of the combination of N-(phosphonacetyl)-L-aspartate (PALA) and fluorouracil (5-FU). This review covers the biochemistry involved, the preclinical findings, the many clinical trials, and explains the differences between the initial unsuccessful and the later successful clinical studies. The overall findings demonstrate that, to be successful, the design of modulation-based clinical trials should adhere to the principles determined in preclinical studies.
Three-dimensional deformation field measurements with simultaneous TV holography and electronic speckle photography (1997)

The ordinary recordings of TV holography (phase-stepped electronic speckle interferometry), arranged for out-of-plane sensitivity, are recombined and also analyzed by use of electronic speckle photography for simultaneous measurements of all three components of the deformation vector field. The principles of this technique are presented. Experimental results showing the opening of a slot in a perspex plate are also presented.
Hypothermia as an adjunct therapy to vesicant-induced skin injury. (2008)

The simple and noninvasive application of cooling measures may not only provide significant therapeutic relief to vesicant-exposed skin but also increase the therapeutic window in which medical countermeasures against vesicant agents are useful.
Dynamic corneal imaging (2005)

Dynamic corneal imaging induced a reproducible and reversible change in corneal topography corresponding to the different indentation depths. The results indicate that several clinical parameters are correlated with corneal elastic behavior in vivo and that the technology could increase the predictability of refractive corneal surgery and help in the early diagnosis of corneal diseases and with newly developed therapies.