gebhart/patrepeval huggingface dataset:
A Framework for Qualitative Performance Prediction (1998)

Performance prediction models at the source code level are crucial components in advanced optimizing compilers, programming environments, and tools for performance debugging. Compilers and programming environments use performance models to guide the selection of effective code improvement strategies. Tools for performance debugging may use performance prediction models to explain the performance behavior of a program to the user. Finding the best match between a performance prediction model and a specific source–level optimization task or performance explanation task is a challenging problem. The best performance prediction model for a given task is a model that satisfies the precision requirements while including as few performance factors as possible in order to minimize the cost of the performance predictions. In optimizing compilers, the lack of such a cost–effective performance model may make the application of an optimization prohibitively expensive. In the context of a programming environment, marginal performance factors should be avoided since they will obscure reasoning about the observed performance behavior. This paper discusses a new qualitative performance prediction framework at the program source level that automatically selects a minimal set of performance factors for a target system and performance precision requirement. In the context of this paper, a target system consists of a compiler, an operating system, and a machine architecture. The performance prediction framework identifies significant target system and application program parameters that have to be considered in order to achieve the requested precision. Such parameters may include application factors such as number and type of floating point operations, and machine characteristics such as L1 and L2 caches, TLB, and main memory. The reported performance factors can be used by a compiler writer to build or validate a quantitative performance model, and by a user to better understand the observed program performance. In addition, the failure of the framework to produce a model of the desired quality may be an indication that there exists a significant performance factor not considered within the performance framework. Such information is important to guiding a compiler writer or user in a more efficient search for crucial performance factors. Preliminary experimental results for a small computation kernel and a set of twelve target systems indicate the effectiveness of our framework. The target systems for the experiment consisted of four machine architectures (SuperSPARC I-II and UltraSPARC I-II running Solaris 2.5) and three compiler optimization levels (-none, -O3, -depend -fast). Our prototype framework determines different performance models (1) across different precision requirements for the same target system, and (2) across different target systems for the same precision requirement. In addition, the prototype framework leads us to the discovery of a performance factor within the operating system by failing to produce a performance model of a requested precision.
Ueber ein neues Nitroanthrachinon und Amidoanthrachinon, sowie eine neue Darstellungsweise des Erythrooxyanthrachinons (1882)

genao in derselben Weise wie die des Alizarinblaus S. Die L6sangen triilwn sic11 und es scheidet sich Chinolin aus.Es erscheint uiis daher nicht zweifrlhaft,
Living with a Tabletop: Analysis and Observations of Long Term Office Use of a Multi-Touch Table (2007)

Multi-touch tabletops have been the focus of significant recent study but, to date, few devices have moved from prototype to installed use. In this paper, we present observation and analysis of a subject who has used a direct-touch tabletop as his primary computing environment for the past 13 months, driving all manner of applications in a standard MS Windows environment. We present the results of three research instruments: a structured interview with the user, an analysis of touch and click locations when operating in desktop and tabletop modes over several days, and linguistic analysis of email composition over several months. From the product of these instruments we then report on several open avenues for research, including physical parameters, hardware limitations, touch vs. click in the WIMP, and text entry techniques.
A 6-GHz integrated phase-locked loop using AlGaAs/GaAs heterojunction bipolar transistors (1992)

A fully integrated 6-GHz phase-locked-loop (PLL) fabricated using AlGaAs/GaAs heterojunction bipolar transistors (HBTs) is described. The PLL is intended for use in multigigabit-per-second clock recovery circuits for fiber-optic communication systems. The PLL circuit consists of a frequency quadrupling ring voltage-controlled oscillator (VCO), a balanced phase detector, and a lag-lead loop filter. The closed-loop bandwidth is approximately 150 MHz. The tracking range was measured to be greater than 750 MHz at zero steady-state phase error. The nonaided acquisition range is approximately 300 MHz. This circuit is the first monolithic HBT PLL and is the fastest yet reported using a digital output VCO. The minimum emitter area was 3 mu m*10 mu m with f/sub t/=22 GHz and f/sub max/=30 GHz for a bias current of 2 mA. The speed of the PLL can be doubled by using 1- mu m*10- mu m emitters in next-generation circuits. The chip occupies a die area of 2-mm*3-mm and dissipates 800 mW with a supply voltage of -8 V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate (2010)

We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism.
Sarcoplasmic reticulum calcium release compared in slow-twitch and fast-twitch fibres of mouse muscle (2003)

Experiments were carried out to compare the amplitude and time course of Ca2+ release from the sarcoplasmic reticulum (SR) in intact slow-twitch and fast-twitch mouse fibres. Individual fibres within small bundles were injected with furaptra, a low-affinity, rapidly responding Ca2+ indicator. In response to a single action potential at 16 degrees C, the peak amplitude and half-duration of the change in myoplasmic free [Ca2+] (Delta[Ca2+]) differed significantly between fibre types (slow-twitch: peak amplitude, 9.4 +/- 1.0 microM (mean +/- S.E.M.); half-duration, 7.7 +/- 0.6 ms; fast-twitch: peak amplitude 18.5 +/- 0.5 microM; half-duration, 4.9 +/- 0.3 ms). SR Ca2+ release was estimated from Delta[Ca2+] with a computational model that calculated Ca2+ binding to the major myoplasmic Ca2+ buffers (troponin, ATP and parvalbumin); buffer concentrations and reaction rate constants were adjusted to reflect fibre-type differences. In response to an action potential, the total concentration of released Ca2+ (Delta[CaT]) and the peak rate of Ca2+ release ((d/dt)Delta[CaT]) differed about 3-fold between the fibre types (slow-twitch: Delta[CaT], 127 +/- 7 microM; (d/dt)Delta[CaT], 70 +/- 6 microM ms-1; fast-twitch: Delta[CaT], 346 +/- 6 microM; (d/dt)Delta[CaT], 212 +/- 4 microM ms-1). In contrast, the half-duration of (d/dt)Delta[CaT] was very similar in the two fibre types (slow-twitch, 1.8 +/- 0.1 ms; fast-twitch, 1.6 +/- 0.0 ms). When fibres were stimulated with a 5-shock train at 67 Hz, the peaks of (d/dt)Delta[CaT] in response to the second and subsequent shocks were much smaller than that due to the first shock; the later peaks, expressed as a fraction of the amplitude of the first peak, were similar in the two fibre types (slow-twitch, 0.2-0.3; fast-twitch, 0.1-0.3). The results support the conclusion that individual SR Ca2+ release units function similarly in slow-twitch and fast-twitch mammalian fibres.
In situ measurement of time-series two dimensional O2 distributions at sediment-water interface using a planar O2 optode system connected with a submarine cable (2007)

The first long time monitoring of O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> dynamics at sediment-water interface (SWI) was conducted using with a newly developed planar O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> optode system for in situ measurement. The monitoring was carried out connecting the optode system with Hatsushima permanent station with a 100 meter-long extension cable under supporting by the operation of ROV Hyper-dolphin. The monitoring was successfully carried out for 113.3 hours. During the experiment, 3,141 two dimensional O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> profiles and the corresponding pseudo-grayscale images across SWI were obtained, respectively. From the results, further understanding of new insights on dynamic interactions between fauna activities and environmental changes are expected.
Loop-mediated isothermal amplification of Neisseria gonorrhoeae porA pseudogene: a rapid and reliable method to detect gonorrhea (2017)

LAMP was sensitive and reliable for detecting the porA gene of N. gonorrhoeae. It could be used as a rapid, low cost, and effective method for detecting N. gonorrhoeae.
Improved optical properties of silica/UV-cured polymer composite films made of hollow silica nanoparticles with a hierarchical structure for light diffuser film applications (2016)

This study successfully improved the optical properties of silica/UV-cured polymer composite films made of hollow silica nanoparticles having a hierarchical structure. The particles were synthesized by an inorganic particle method, which involves two steps of sol-gel silica coating around the template and acid dissolution removal of the template. The pH of the acid was varied to achieve different hierarchical structures of the particles. The morphologies and surface properties of the obtained particles were characterized before dispersing in a UV-curable acrylate monomer solution to prepare dispersions for fabricating light diffuser films. The optical properties and the light diffusing ability of the fabricated films were studied. The results revealed that the increased pH of the acid provides the particles with a thinner shell, a larger hollow interior and a higher specific surface area. Moreover, the films with these particles exhibit a better light diffusing ability and a higher diffuse transmittance value when compared to those without particles. Therefore, the composite films can be used as light diffuser films, which is an essential part of optical diffusers in the back-light unit of LCDs. In addition, utilizing the hierarchical particles probably reduces the number of back-light units in the LCDs leading to energy-savings and subsequently lightweight LCDs.
Thermoplastic Elastomers (2009)

No AccessRubber TechnologyOct 2009Thermoplastic ElastomersCharles P. RaderCharles P. Raderhttps://doi.org/10.3139/9783446439733.010SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2009Pages: 264-283Print ISBN: 978-3-446-42155-4eISBN: 978-3-446-43973-3 Copyright & Permissions© 2009 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis (2019)

Patients with relapsing multiple sclerosis who received 75 mg of evobrutinib once daily had significantly fewer enhancing lesions during weeks 12 through 24 than those who received placebo. There was no significant difference with placebo for either the 25-mg once-daily or 75-mg twice-daily dose of evobrutinib, nor in the annualized relapse rate or disability progression at any dose. Longer and larger trials are required to determine the effect and risks of evobrutinib in patients with multiple sclerosis. (Funded by EMD Serono; ClinicalTrials.gov number, NCT02975349.).
Novel asymmetric Y-branches for planar lightwave circuits (1996)

Summary form only given. Novel asymmetric Y-branches with an arbitrary optical splitting, to our knowledge, have been proposed for the first time. The emergence of asymmetric Y-branches would give increased freedom to the design of optical circuits, resulting in the flexibility of optical communication systems. This paper presents novel asymmetric Y-branches with an arbitrary splitting ratio, which have flattened spectral response in the wavelength range from 1.2 /spl mu/m to 1.6 /spl mu/m and small polarization dependent loss (PDL).
IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10 (1992)

Abstract T cell-derived cytokines IFN-gamma and IL-4 have different regulatory effects on two functionally important molecules on human monocytes: MHC class II Ag and the Fc receptor for monomeric IgG, Fc gamma RI (CD64). MHC class II Ag, and Fc gamma RI are both upregulated in the presence of IFN-gamma. IL-4 induces MHC class II Ag expression but reduces Fc gamma RI expression. Recently, we showed that the cytokine IL-10 also affects MHC class II Ag expression. Here, we demonstrate that in contrast to the down-regulation of MHC class II Ag expression, IL-10 stimulates Fc gamma RI expression on human monocytes comparable to the levels of Fc gamma RI expression induced by IFN-gamma. The IL-10-induced Fc gamma RI expression is specific because anti-IL-10 antibodies completely reverse the IL-10-induced surface expression of Fc gamma RI and correlate with an enhanced capacity to lyse anti-D-coated human rhesus-positive erythrocytes. IL-10 fails to induce the expression of Fc gamma RII (CD32) and Fc gamma RIII (CD16). Furthermore, we demonstrate that IL-10 is able to prevent down-regulation in surface membrane expression of all three Fc gamma R that can be found when monocytes are cultured in the presence of IL-4. In contrast to IFN-gamma, IL-10 does not restore the reduced antibody-dependent cellular cytotoxicity (ADCC) activity of IL-4-cultured monocytes. Together, these results show that, similar to IFN-gamma, IL-10 is capable of enhancing Fc gamma R expression and ADCC activity, and that IFN-gamma, IL-4, and IL-10 have different regulatory effects on both monocyte Ag-presenting capacity and ADCC activity.
Application of the global navigation satellite systems to spacecraft landing. Attitude determination and earth observation constellations (1996)

La tesis contiene en primer lugar una descripcion basica aunque rigurosa de los conceptos fundamentales de los sistemas de navegacion global por satelite (gnss).En esta etapa se proponen soluciones encaminadas a la reduccion de errores de posicionamiento. Posteriormente la tesis aborda un estudio detallado y riguroso de varias aplicaciones de gran interes: el control de aterrizaje y determinacion de actitud angular precisos de aeronaves o vehiculos espaciales de dinamica rapida, asi como algunas aplicaciones de las tecnicas desarrolladas, a la observacion de la tierra desde el espacio. El contenido de la tesis es de una gran calidad, originalidad e interes cientifico siendo notable el grado de verificacion experimental de los metodos propuestos.
The Key Drivers and Barriers to the Sustainable Development of Commercial Property in New Zealand (2012)

In 2011 research was conducted to identify the key drivers and barriers to the sustainable development of commercial property in New Zealand (NZ) by surveying a cross-section of these market participants. The overall aim of the research was to identify any barriers that need to be overcome so that progress can be made towards advancing the sustainable building agenda in NZ's commercial property sector that will help improve building energy performance and reduce greenhouse gas emissions. The results indicate there remain key issues for the property industry to resolve, the most significant of which is the commercial property sectors' view of the cost premium for green buildings versus conventional buildings.
Fast transient response with combined linear-non-linear control applied to buck converters (2003)

Nowadays, one of the main challenges for power supplies designers is to feed the latest generation of microprocessors and DSPs, since they require high current slew rates together with low output voltage. In this paper, a novel control technique is presented to help the designers to comply with the current requirements. The proposed combined linear-nonlinear control (LnLC) scheme increases significantly the capability of conventional linear control to reduce the recovery time of the output voltage drop produced when a load current step occurs. Experimental results have been obtained for two cases: a synchronous rectifier buck converter, with a conventional voltage loop and the same converter with the novel LnLC. The comparison of these experimental results shows that, with the new control, the recovery time of the output voltage is reduced.
The Microstrip Step Discontinuity: A Revised Description (1986)

A systematic variety of frequency-dependent numerical results hitherto unavailable are presented for the shielded microstrip impedance step. The computational method used is a rigorous full-wave spectral-domain approach developed by Jansen. The given data describe the steps for two very common groups of dielectric substrates as a function of stepwidth ratio in the range of normalized frequencies where it behaves like a two-port. They represent new MIC design information and are compared with quasi-static results and the widely used magnetic-wall waveguide approximation. Beyond this, they are validated against the sparse step-discontinuity data available from previous rigorous approaches.
QoS Aware Middleware Support for Dynamically Reconfigurable Component Based IoT Applications (2016)

Sensor web systems, cyber-physical systems, and the so-called Internet of Things are concepts that share a set of common characteristics. The nature of such systems is highly dynamic and very heterogeneous and issues such as interoperability, energy consumption, or resource management must be properly managed to ensure the operation of the applications within the required quality of service level. In this context, base technologies such as component based software engineering or Service Oriented Architecture can play a central role. Model driven development and middleware technologies also aid in the design, development, and operation of such systems. This paper presents a middleware solution that provides runtime support for the complete lifecycle management of a system consisting of several concurrent applications running over a set of distributed infrastructure nodes. The middleware builds up on top of a general purpose component model and is driven by a quality of service aware self-configuration algorithm that provides stateful reconfiguration capabilities in face of both internal (application triggered) and external (application unaware) reconfiguration events. The platform has been deployed over an automated warehouse supervision system that serves as a case study.
Structure–activity Relationships for Tumour Radiosensitization by Analogues of Nicotinamide and Benzamide (1991)

Nicotinamide has been shown in our laboratory and those of other investigators to be an effective radiosensitizer of a variety of mouse tumours, while producing little or no radiosensitization of normal tissues. Its mechanism of action is different from classical electron-affinic compounds and appears to be the result of improved tumour oxygenation. In this study we have synthesized 29 analogues of nicotinamide and benzamide and characterized them for their tumour radiosensitization and acute toxicity in mice. The data show that a wide range of additions to the nicotinamide and benzamide ring produce tumour radiosensitization similar to that produced by equimolar doses of misonidazole, but that substitutions of the amide tend to reduce radiosensitization. Other structure-activity relationships are evident. Although some compounds produce similar tumour radiosensitization to nicotinamide at equimolar doses, and are comparably low in acute toxicity, none appears sufficiently superior to supplant nicotinamide itself as a candidate for clinical trials. Thus these data provide evidence that nicotinamide, because of the extensive experience with its use in man, is likely to be the best drug in the benzamide-nicotinamide series for development as a radiosensitizer of human tumours.
1-V<inf>pp</inf> 10-Gb/s operation of slow-light silicon Mach-Zehnder modulator in wavelength range of 1 nm (2010)

We developed a slow-light silicon Mach-Zehnder modulator utilizing cascaded ring resonators. It operates at 10 Gb/s with driving voltage of 1 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> in a wavelength range of 1 nm without adjustment for the resonant wavelengths.
Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene (2016)

Human pluripotent stem cells (hPSCs) hold great promise for cell therapy. However, a major concern is the risk of tumor formation by residual undifferentiated cells contaminating the hPSC-derived cell product. Suicide genes could safeguard against such adverse events by enabling elimination of cells gone astray, but the efficacy of this approach has not yet been thoroughly tested. Here, we engineered a lentivirally encoded herpes simplex virus thymidine kinase (HSVtk) with expression restricted to undifferentiated hPSCs through regulation by the let7 family of miRNAs. We show that induced pluripotent stem cells (iPSCs) expressing a let7-regulated HSVtk transgene are selectively killed by ganciclovir (GCV), whereas differentiated cells are fully protected. However, in contrast to previous studies, we find that in vivo GCV administration results in longer latency but does not prevent teratoma formation by iPSCs expressing either a constitutive or a let7-regulated HSVtk, without evidence of silencing of the HSVtk. Clonal analyses of iPSCs expressing HSVtk revealed frequent emergence of GCV resistance which, at least in some cases, could be attributed to preexisting inactivating mutations in the HSVtk coding sequence, selected for upon GCV treatment. Our findings have important consequences for the future use of suicide genes in hPSC-based cell therapies.
Studies in the molecular weight distribution of epoxide resins. III. Gel permeation chromatography of epoxide resins subject to postglycidylation (1975)

Unambiguous evidence has been provided for the existence of a branched structure in liquid epoxide resins which have been subjected to postepoxidation with excess epichlorohydrin in the presence of a powerful nucleophilic catalyst, tetramethylammonium chloride. Gel chromatography of the resin on Sephadex LH-20 followed by isolation and identification of the relevant fraction by spectroscopic techniques revealed the presence of a novel trifunctional epoxide having a molecular weight of 680.
Derivatization of the fullerene dications C{sub 60}{sup 2+} and C{sub 70}{sup 2+} by ion-molecule reactions in the gas phase (1992)

This study focuses on the derivatization of the fullerene dications C{sub 60}{sup 2+} and C{sub 70}{sup 2+} by ion-molecule reactions in the gas phase. This was accomplished using a Selected-Ion Flow Tube (SIFT) apparatus. A model is also presented which relates the efficiency of adduct formation to the ionization energy, the size, and the degree of unsaturation of the molecules. 28 refs., 3 figs., 3 tabs.