gebhart/patrepeval huggingface dataset:
Micropulsation Instrumentation Systems at the Dallas Geomagnetic Center (1967)

Scientists from the Graduate Research Center of the Southwest, Texas Christian University, and Texas Instruments Incorporated are conducting theoretical and experimental studies of the effects of magnetohydrodynamic (MHD) waves on low-frequency (10-4 to 100 cps) fluctuations in the earth's electromagnetic field (often called micropulsations). The experimental part of the program involves the operation of an observatory for the sensing and collection of micropulsation data. This micropulsation observatory, together with a U. S. Coast and Geodetic Survey Standard magnetographic observatory, are collectively known as the Dallas Geomagnetic Center. The magnetic field changes in N-S and E-W geomagnetic directions are sensed by means of induction coils with six foot long mu-metal cores, short iron core coils, an Automatic Standard Magnetic Observatory (ASMO) which uses a rubidium vapor magnetometer, and by standard magnetographs. Corresponding electric field changes are sensed by electrode pairs buried in the Earth a few hundred feet apart. The data which consists of recordings of fluctuations in the earth's magnetic and electric fields in a range from a few cycles per month to a few cycles per second (cps) is available in the form of reproducible paper charts, analog magnetic tape, digital magnetic tape, and punched paper tape, or IBM cards.
Angiotensin II Stimulates System y+ and Cationic Amino Acid Transporter Gene Expression in Cultured Vascular Smooth Muscle Cells (1995)

The effect of angiotensin II (Ang II) on the transport of cationic amino acids has been examined in vascular smooth muscle cells (VSMC) isolated from rat aortae. Ang II stimulated the uptake rates of radiolabeled arginine and lysine in a time- and concentration-dependent manner. The stimulated arginine uptake could be blocked by pretreatments with cycloheximide and actinomycin D or co-treatment with valsartan, an antagonist specific for Ang II receptor subtype-1. The modulation by Ang II was bidirectional as the efflux of arginine was also stimulated, 5-fold over basal. Using reverse transcription-coupled polymerase chain reaction methodology, a partial cDNA with 94% sequence identity to that of cationic amino acid transporter subtype-1 (CAT-1) of mouse fibroblasts was obtained from VSMC. This sequence also exhibited 14 base changes compared with the sequence of ecotropic retrovirus receptor (ERR)/CAT-1 from rat hepatoma. Northern analyses with this partial CAT-1 cDNA and CAT-2 cDNA of mouse T-lymphocytes showed that Ang II rapidly stimulated the expression of both CAT-1 and CAT-2 in VSMC. Both signals peaked at 2 h after exposure to Ang II. The CAT-1 signal decayed over the next 6 h to levels 3-fold above basal, which are maintained up until 24 h. The induced CAT-2 mRNA concentration also decayed rapidly but increased again between 16 and 24 h to levels comparable with those observed at 2 h.
Are Some Mutual Fund Managers Better Than Others? Cross‐Sectional Patterns in Behavior and Performance (1999)

We examine whether mutual fund performance is related to characteristics of fund managers that may indicate ability, knowledge, or effort. In particular, we study the relationship between performance and the manager's age, the average composite SAT score at the manager's undergraduate institution, and whether the manager has an MBA. Although the raw data suggest striking return differences between managers with different characteristics, most of these can be explained by behavioral differences between managers and by selection biases. After adjusting for these, some performance differences remain. In particular, managers who attended higher‐SAT undergraduate institutions have systematically higher risk‐adjusted excess returns.
The Use of a Four-Channel Electrical Stimulator as an Ambulatory Aid for Paraplegic Patients (1983)

This article reports the use of electrical stimulation to provide paraplegic patients with complete lesions of the spinal cord the ability to rise from sitting to standing, to maintain a standing position, and to walk with a reciprocal gait. Four channels of electrical stimulation are sufficient for synthesis of a simple reciprocal gait pattern in these patients. During the double-stance phase, knee extensor muscles of both knees are stimulated, providing sufficient support for the body. Only one knee extensor muscle group is excited during the single-stance phase. The swing phase of the contralateral lower extremity is accomplished by eliciting the synergistic flexor muscle response through electrical stimulation of afferent nerves. The transition from the double-stance phase to the swing phase is controlled by two hand switches used by the therapist or built into the handles of the walking frame or crutches for use by the patient.
Variance Reduction via Adaptive Control Variates (ACV) (1996)

Control Variate (CV) is very useful technique for variance reduction in a wide class of queueing network simulations. However, the loss in variance reduction caused by the estimation of the optimum control coefficients is an increasing function of the number of control variables. Therefore, in some situations, it is required to select an optimal set of control variables to maximize the variance reduction. In this paper, we develop the Adaptive Control Variates (ACV) method which selects an optimal set of control variates during the simulation adatively. ACV is useful to maximize the simulation efficiency when we need iterated simulations to find an optimal solution. One such an example is the Simulated Annealing (SA) because, in SA algorithm, we have to repeat in calculating the objective function values at each temperature. The ACV can also be applied to the queueing network optimization problems to find an optimal input parameters (such as service rates) to maximize the throughput rate with a certain cost constraint.
Robust tracking controller for a seeker scan loop (1999)

This paper deals with the problem of designing a robust tracking controller for a seeker scan loop where the plant model contains uncertainty. The goal is to have the seeker accurately track specific scan patterns in the presence of system uncertainty. Two scan patterns, the circular and the rosette, are generated as reference models and used in the simulation to test the robustness of the controllers. Results from H/sup /spl infin// control theory for full state feedback and output feedback are used to design the controllers. Furthermore, to limit the control force magnitude to satisfy physical constraints, a special filtering procedure is introduced. For both scan patterns, it is shown that robust controllers can be determined so that the scan loop accurately tracks the scan patterns even with model uncertainty up to 100%.
Simple algorithms and architectures for B-spline interpolation (1988)

It is proved that the Toeplitz binary value matrix inversion associated with mth-order B-spline interpolation can be implemented using only 2(m+1) additions. Pipelined architectures are developed for real-time B-spline interpolation based on simple running average filters. It is shown that an ideal interpolating function, which is approximated by a truncated sinc function with M half cycles, can be implemented using B-splines with M+2 multiplies. With insignificant loss of performance, the coefficients at the knots of the truncated sinc function can be approximated using coefficients which are powers of two. The resulting implementation requires only M+4m+6 additions. It is believed that the truncated sinc function approximated by zero-order B-spline functions actually achieves the best visual performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Feature Extraction By Using Deep Learning: A Survey (2018)

Deep learning is presently an effective research area in machine learning technique and pattern classification association. This has achieved big success in the areas of application namely computer vision, speech recognition, and NLP. This paper gives the impact of feature extraction that used in a deep learning technique such as Convolutional Neural Network (CNN). The purpose of this paper presents an emerged survey of actual literatures on feature extraction methods since past five years. As the raising of application demand increases, a large study and analysis in the feature extraction field became very efficient. In this paper, we presented a detailed study on deep learning, and a described some of existing methodology of feature extraction.
Safety and tolerability of once monthly aripiprazole treatment initiation in adults with schizophrenia stabilized on selected atypical oral antipsychotics other than aripiprazole (2013)

Safety and Tolerability Trial of Aripiprazole IM Depot Treatment in Adult Subjects With Schizophrenia Stabilized on Oral Antipsychotics Other Than Aripiprazole. ID number: NCT01552772. Registry: clinicaltrials.gov.
The Antioxidant Function of Metallothionein in the Heart (1999)

The antioxidant function of metallothionein (MT) was first suggested in the early 1980s. Studies in vitro have revealed that MT reacts directly with reactive oxygen species, including superoxide and hydroxyl radicals and hydrogen peroxide. These reactions have never been demonstrated in intact animal studies. Nevertheless, both pharmacologic and genetic studies have shown that MT functions in protection against oxidative injury in vivo. In particular, the antioxidant function of MT in the heart has been explored extensively. The data gathered from recent studies using a cardiac-specific, MT-overexpressing transgenic mouse model have provided direct evidence to support this physiological role of MT. Under acute and chronic oxidative stress conditions such as treatment with doxorubicin, ischemia-reperfusion, and dietary copper restriction, MT-overexpressing transgenic mouse hearts displayed a marked resistance to the injurious consequences, including biochemical, pathological, and functional alterations. This protective action of MT correlates with its inhibition of reactive oxygen species-induced lipid peroxidation. A critical elucidation of the mechanism of action of MT as an antioxidant in vivo remains to be achieved. However, the combination of recent understanding of the zinc cluster structure of MT and novel molecular genetic approaches has provided the basis for further advancement in this field.
Folded silicon resonant accelerometer with temperature compensation (2006)

In this paper, a novel folded silicon resonant accelerometer is proposed. The proposed structure is able to release the stress arising from the mismatch of thermal expansion between silicon structure and glass substrate and to compensate the variation of the natural frequency with temperature. The analysis has shown that both bias and scale factor stability can be improved with the proposed structure. The concept is verified by simulation and the results show that the temperature dependence of common-mode output frequency can be greatly reduced.
Periodontal Tissue Regeneration with Adipose-Derived Stem Cells (2008)

A number of surgical techniques have been developed to promote periodontal tissue regeneration. Bone marrow-derived stem cells have also been shown to promote periodontal tissue regeneration. In this study, we sought to determine whether adipose-derived stem cells (ASCs) can promote periodontal tissue regeneration as well. ASCs were isolated from a Wistar rat, passaged twice, mixed with platelet-rich plasma (PRP) obtained from inbred rats, and implanted into the periodontal tissue defect that had been generated in the test rats. Tissue specimens were harvested after 2, 4, and 8 weeks for histological analysis. Rats that received PRP only or were not implanted served as controls. A small amount of alveolar bone regeneration was observed 2 and 4 weeks after ASC/PRP implantation. Moreover, 8 weeks after implantation, a periodontal ligament-like structure was observed along with alveolar bone. These observations suggest that ASCs can promote periodontal tissue regeneration in vivo. Because large amounts of human lipoaspirates are readily available, and their procurement induces only low morbidity, ASCs may be useful in future clinical cell-based therapy for periodontal disease.
Reaction products of cis-diammineplatinum(II) compounds with 5'-guanosine monophosphate characterized by high-frequency proton NMR (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction products of cis-diammineplatinum(II) compounds with 5'-guanosine monophosphate characterized by high-frequency proton NMRFransje J. Dijt, Gerard W. Canters, Jeroen H. J. Den Hartog, Antonius T. M. Marcelis, and Jan ReedijkCite this: J. Am. Chem. Soc. 1984, 106, 12, 3644–3647Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ja00324a039https://doi.org/10.1021/ja00324a039research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca <sup>2+</sup> Releases (2008)

Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated, protein kinase A-dependent local subsarcolemmal ryanodine receptor Ca(2+) releases (LCRs). LCRs activated an inward Na(+)/Ca(2+) exchange current that increases the terminal diastolic depolarization rate and, therefore, the spontaneous SANC beating rate. Basal cAMP in SANCs is elevated, suggesting that cAMP degradation by phosphodiesterases (PDEs) may be low. Surprisingly, total suppression of PDE activity with a broad-spectrum PDE inhibitor, 3'-isobutylmethylxanthine (IBMX), produced a 9-fold increase in the cAMP level, doubled cAMP-mediated, protein kinase A-dependent phospholamban phosphorylation, and increased SANC firing rate by approximately 55%, indicating a high basal activity of PDEs in SANCs. A comparison of specific PDE1 to -5 inhibitors revealed that the specific PDE3 inhibitor, milrinone, accelerated spontaneous firing by approximately 47% (effects of others were minor) and increased amplitude of L-type Ca(2+) current (I(Ca,L)) by approximately 46%, indicating that PDE3 was the major constitutively active PDE in the basal state. PDE-dependent control of the spontaneous SANC firing was critically dependent on subsarcolemmal LCRs, ie, PDE inhibition increased LCR amplitude and size and decreased LCR period, leading to earlier and augmented LCR Ca(2+) release, Na(+)/Ca(2+) exchange current, and an increase in the firing rate. When ryanodine receptors were disabled by ryanodine, neither IBMX nor milrinone was able to amplify LCRs, accelerate diastolic depolarization rate, or increase the SANC firing rate, despite preserved PDE inhibition-induced augmentation of I(Ca,L) amplitude. Thus, basal constitutive PDE activation provides a novel and powerful mechanism to decrease cAMP, limit cAMP-mediated, protein kinase A-dependent increase of diastolic ryanodine receptor Ca(2+) release, and restrict the spontaneous SANC beating rate.
The Development of human-arm like manipulator for Laparoscopic Surgery with Force sensing (2006)

This paper describes design of the dexterous manipulator for laparoscopic surgery that performs like a human whole arm and the FEM simulation result to measure the force of its tool-tip to include force-feedback loop for the future. Though a human whole arm has 7 degrees of freedom, we have designed overall 8 degrees of freedom because of considering one dof translation motion that corresponds with human body movement. Some researchers reported that if we could develop either mechanical or electromechanical tele-operators which enable surgeons to move a MIS system in a manner analogous to an open instrument, we could potentially reduce the time of current laparoscopic procedures by at least 15% and we could perhaps also enable surgeons to perform procedures which are thought currently too difficult to execute. Accordingly, we are expecting that the suggested design provides surgeon with improved dexterity during minimally invasive surgery.
Contrast study of the effect of bisoprolol and carvedilol in patients with essential hypertension (2003)

Objective: To observe the effect and safety of bisoprolol and carvedilol in patients with essential hypertension.Methods: 128 patients with essential hypertension were divided randomly into treatment group (n=64) and control group (n=64).The patients of treatment group were administrated 2.5～10.0 mg bisoprolol once a day for 6 weeks,while the patients of control group with 25～50 mg carvedilol.24h-ambulatory blood pressure monitory (ABPM) was used in 38 cases in treatment group.Results: Total effective rate was 80.7% in treatment group and 80.0% in control group. SBP and DBP reductions in treatment group were 1.86 kPa and 1.44 kPa, and in control group were 2.02 kPa and 1.49 kPa. There was no significant difference in total effective rate between the two groups. The blood pressure load,mean SBP and DBP in daytime and night were significantly lower than pretreatment level.The T/P ratios of SBP and DBP were both above 50%.Conclusion: The bisoprolol and carvedilol are effective and well tolerated in treating essential hypertension.
Abstract PL07-02: Genome sequencing of triple-negative breast cancer in African American women. (2012)

Abstract It is universally accepted that somatic alterations (i.e., point mutations, small insertions and deletions, rearrangements, gains and losses) occur at the DNA level in cancer. These somatic events can drive tumorigenesis, metastatic progression, and/or drug resistance. More importantly, specific somatic alterations are intimately tied to companion targeted therapeutics. Recent technological advances in the form of Next Generation Sequencing technologies now provide us with platforms to interrogate entire human genomes at a fraction of the time and cost compared to more traditional sequencing technologies. These technologies are already being used to survey the global somatic landscape of tumors across large cohorts. As many cancer types disproportionately affect underrepresented populations, this session will highlight new findings from deep genomic profiling of tumors from individuals from diverse populations. Ultimately it is our hope to glean new insights into the possible role of somatic events. Citation Format: John D. Carpten. Genome sequencing of triple-negative breast cancer in African American women. [abstract]. In: Proceedings of the Fifth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2012 Oct 27-30; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2012;21(10 Suppl):Abstract nr PL07-02.
Thou Shalt Not Depend on Me: Analysing the Use of Outdated JavaScript Libraries on the Web (2017)

Author(s): Tobias Lauinger, Abdelberi Chaabane, Sajjad Arshad, William Robertson, Christo Wilson, Engin Kirda Download: Paper (PDF) Date: 27 Feb 2017 Document Type: Reports Associated Event: NDSS Symposium 2017 Abstract: Web developers routinely rely on third-party Java- Script libraries such as jQuery to enhance the functionality of their sites. However, if not properly maintained, such dependencies can create attack … Continued
Thermal stability and electrical characteristics of ultrathin hafnium oxide gate dielectric reoxidized with rapid thermal annealing (2000)

Dielectric properties of ultrathin hafnium oxide reoxidized with rapid thermal annealing (RTA) have been investigated. Capacitance equivalent oxide thickness (CET) of 45 Å hafnium oxide was scaled down to ∼10 Å with a leakage current less than 3×10−2 A/cm2 at −1.5 V (i.e., ∼2 V below VFB). Leakage current increase due to crystallization was not observed even after 900 °C rapid thermal annealing (RTA), but CET did increase after high temperature RTA due to the interfacial layer growth and possible silicate formation in the HfO2 film.
Control of the microporosity within the pore walls of ordered mesoporous silica SBA-15 (2000)

Microporosity within the pore walls of ordered mesoporous silica SBA-15 was confirmed by physisorption; the micropore volume could be systematically controlled by varying the synthesis temperature and the TEOS/surfactant ratio.
Antisense-Mediated RNA Targeting: Versatile and Expedient Genetic Manipulation in the Brain (2011)

A limiting factor in brain research still is the difficulty to evaluate in vivo the role of the increasing number of proteins implicated in neuronal processes. We discuss here the potential of antisense-mediated RNA targeting approaches. We mainly focus on those that manipulate splicing (exon skipping and exon inclusion), but will also briefly discuss mRNA targeting. Classic knockdown of expression by mRNA targeting is only one possible application of antisense oligonucleotides (AON) in the control of gene function. Exon skipping and inclusion are based on the interference of AONs with splicing of pre-mRNAs. These are powerful, specific and particularly versatile techniques, which can be used to circumvent pathogenic mutations, shift splice variant expression, knock down proteins, or to create molecular models using in-frame deletions. Pre-mRNA targeting is currently used both as a research tool, e.g., in models for motor neuron disease, and in clinical trials for Duchenne muscular dystrophy and amyotrophic lateral sclerosis. AONs are particularly promising in relation to brain research, as the modified AONs are taken up extremely fast in neurons and glial cells with a long residence, and without the need for viral vectors or other delivery tools, once inside the blood brain barrier. In this review we cover (1). The principles of antisense-mediated techniques, chemistry, and efficacy. (2) The pros and cons of AON approaches in the brain compared to other techniques of interfering with gene function, such as transgenesis and short hairpin RNAs, in terms of specificity of the manipulation, spatial, and temporal control over gene expression, toxicity, and delivery issues. (3) The potential applications for Neuroscience. We conclude that there is good evidence from animal studies that the central nervous system can be successfully targeted, but the potential of the diverse AON-based approaches appears to be under-recognized.