gebhart/patrepeval huggingface dataset:
Expression of a high molecular weight cell surface glycoprotein (LETS protein) by preimplantation mouse embryos and teratocarcinoma stem cells (1978)

The expression of a high molecular weight cell surface glycoprotein (LETS, fibronectin) by preimplantation mouse embryos as well as cultured teratocarcinoma stem cells was detected by using indirect immunofluorescent staining. When each stage of preimplantation embryonic development was tested for the presence of LETS protein, none was observed on two-cell, four-cell, or eight-cell embryos, or on the morula or the outer cell layer (trophectoderm) of the early or late blastocyst. However, when the inner cell mass was isolated by immunosurgery, positive staining was observed. The intensity of the staining was significantly greater on the inner cell mass isolated from the expanded (day 4) blastocyst than on that from the early (day 3) blastocyst. Certain established cell lines of teratocarcinoma stem cells (embryonal carcinoma cells) also express cell surface LETS protein. "Nullipotent" (Nulli-SCC-1) as well as pluripotent (PSA 1) embryonal carcinoma cell lines have deposits of LETS protein concentrated in areas of cell-cell contact. In addition, a teratocarcinoma-derived endodermal cell line (PYS) was found to be capable of depositing LETS onto the substratum in a fibrillar network.Taken together, our results indicate that LETS protein is synthesized at a specific stage of preimplantation mouse embryonic development. In particular, they suggest that LETS protein is a product of the embryonic ectoderm, and that some types of embryonic endoderm are also capable of synthesizing this protein.
The Ocular Albinism Type 1 Gene Product is an <i>N</i>‐Glycoprotein but Glycosylation is not Required for its Subcellular Distribution (2001)

The ocular albinism type 1 (OA1) gene product is a membrane glycoprotein that may play a role in controlling melanosome growth and maturation. A number of mutations in the OA1 gene lead to ocular albinism due at least in part to retention of the aberrant protein in the endoplasmic reticulum. To examine whether N-glycosylation plays a role in the post-translational trafficking of the Oa1 protein, we constructed a series of mutant mouse Oa1 cDNAs encoding an Oa1-green fluorescent protein fusion in which some or all of the potential glycosylation sites were eliminated by site-directed mutagenesis. Biochemical studies in transfected cells treated with tunicamycin and peptide:N-glycosidase F suggest that asparagine at amino acid 106 is essential for N-glycosylation of the protein. Mutation at amino acid 106 that eliminated glycosylation did not affect the endo/lysosomal distribution of the Oa1 protein in either COS cells or cultured murine melanocytes.
In vivo detection of radicals in biological reactions. (1994)

In vivo detection of free radicals on a quantitative basis is essential for an establishment of their role in membrane, protein, and cell and tissue damage. This article compares optical methods, including chemiluminescence, electron paramagnetic resonance (EPR) and NMR methods for the study of free radicals and free radical damage, especially reperfusion injury neutrophil accumulation 6 hr after the ischemia/reperfusion insult. The chemiluminescence method is applied to an evaluation of the improved resistance to free radical stress due to transfection of creatine kinase in the mouse liver.
The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative (2012)

Previous studies demonstrate that the endothelin pathway is associated with vasculopathy, neuronal injury and inflammation in ECM. As demonstrated here, components of the ET-1 pathway may be important targets for adjunctive therapy in ECM, and may help in preventing hemorrhage and in improving survival when used as adjunctive therapy during malaria infection. The data presented suggest that our novel agent, HJP-272, may ameliorate alterations in the vasculature which can potentially lead to inflammation, neurological dysfunction, and subsequent death in mice with ECM.
A Rare 920-Kilobase Chromosomal Inversion Mediated by IS1 Transposition Causes Constitutive Expression of the yiaK-S Operon for Carbohydrate Utilization in Escherichia coli (1998)

The regulator of the yiaK-S operon, currently assigned a carbohydrate utilization function in Escherichia coli, is inactivated by a genome rearrangement that leads to the constitutive expression of the operon. The yiaK-S constitutive cells acquire the ability to utilize the rare pentose L-lyxose. Restriction analysis and sequencing of the regulator gene indicate that it is disrupted by foreign DNA. The insert consists of a large inverted fragment of DNA of 920 kilobases flanked by two IS1 elements with opposite polarity. One corresponds to that found naturally at min 0.4 of the bacterial chromosome and the other to a new copy transposed into the regulator gene located at min 80.6. This insertion-inversion could be the result of the intramolecular transposition mechanism itself, a gene rearrangement rarely originated by IS1. Alternatively, it could be attributed to the homologous recombination between the IS1 at min 0.4 and the IS1 transposed intermolecularly into the yiaK-S regulator gene. The participation of a rare IS1-mediated inversion in the evolution of a stable phenotype is thus identified.
Task-Based Core-Periphery Organization of Human Brain Dynamics (2013)

As a person learns a new skill, distinct synapses, brain regions, and circuits are engaged and change over time. In this paper, we develop methods to examine patterns of correlated activity across a large set of brain regions. Our goal is to identify properties that enable robust learning of a motor skill. We measure brain activity during motor sequencing and characterize network properties based on coherent activity between brain regions. Using recently developed algorithms to detect time-evolving communities, we find that the complex reconfiguration patterns of the brain's putative functional modules that control learning can be described parsimoniously by the combined presence of a relatively stiff temporal core that is composed primarily of sensorimotor and visual regions whose connectivity changes little in time and a flexible temporal periphery that is composed primarily of multimodal association regions whose connectivity changes frequently. The separation between temporal core and periphery changes over the course of training and, importantly, is a good predictor of individual differences in learning success. The core of dynamically stiff regions exhibits dense connectivity, which is consistent with notions of core-periphery organization established previously in social networks. Our results demonstrate that core-periphery organization provides an insightful way to understand how putative functional modules are linked. This, in turn, enables the prediction of fundamental human capacities, including the production of complex goal-directed behavior.
Simple negative resist for deep ultraviolet, electron beam, and x-ray lithography (1989)

Negative resists using photo-acid initiated cationic polymerization of epoxy resins were reported in the early 1980s with the advent of onium salts. An efficient, stable onium salt, triphenylsulfonium hexafluoroantimonate produces acid upon exposure to radiation, for example, deep ultraviolet (UV) light, electron beam, and x rays. Combining this onium salt with commercial glycidyl ether epoxy resins provides an inexpensive resist capable of submicron imaging in deep UV, electron beam, and x-ray lithography. Lithographic investigations have concentrated on o-cresol epoxy novolac resin–onium salt resist formulations. Resist contrasts are high, &gt;3 in the deep UV, ≥2 with electron beam, and ≥3 for x ray. Submicron resolution is obtained without solvent swelling. Swelling affects resolution below 0.5 μm, although high aspect ratio sub-half-micron images have been obtained. Epoxide equivalent weight and molecular weight distribution are significant resin properties which influence resist formulating and lithography.
Review of 1,000 Consecutive Short-Scar Rhytidectomies (2008)

BACKGROUND Short-scar rhytidectomies offer patients with mild to moderate facial aging an alternative to traditional face-lift surgery. Advantages of decreased recovery time, diminished risk, and decreased cost make this an attractive procedure to add to a cosmetic surgery practice. METHODS This study is a review of 1,000 consecutive short-scar rhytidectomies performed over 36 months with at least 6 months of follow-up. All patients underwent short-scar rhytidectomy with SMAS suspension. Outcome parameters examined included complications or adverse events and any interventions necessary. RESULTS The most common complication was suture extrusion, observed in 148 patients (14.8%). Ten patients had hematomas (1%), while postauricular nodules were observed in 8 patients (0.8%). Eight patients (0.8%) required liposuction under local anesthesia to address asymmetry due to under removal of fat in the submental region. Revision rhytidectomy was required in 5 patients (0.5%). Five patients (0.5%) had hypertrophic scarring, while 1 patient (0.1%) developed hyperpigmentation. There were no cases of nerve injury, infection, skin flap necrosis, skin puckering or depression, hair loss, or parotid injury. CONCLUSION Short-scar rhytidectomy is an excellent procedure for good candidates with mild to moderate aging of the face. It has a very low complication rate and can be done safely in an office environment.
Effect of humidity cycling on reliability of overlaid high density interconnects (2003)

The authors present a finite element simulation, performed to observe the stresses generated in a typical high-density interconnect structure as a result of swelling mismatches due to water absorption. They focus on stresses which could cause de-adhesion and microbuckling of dielectric films due to humidity cycling. Numerical analysis was used to examine the potential failure sites, modes, and failure mechanisms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Transient noise reduction for hearing aid (2015)

This paper proposes speech enhancement to reduce transient noise. The transient noise is composed of a wideband component which is attack of the noise, and a narrowband component due to a natural oscillation of an object. The duration of a narrowband component is long. Unfortunately, it affects a conversation more than the wideband component. Therefore, we proposed the transient noise reduction for speech. It uses a backward linear predictor using the adaptive algorithm with 4th order cumulant. However, there is a problem that the convergence rate is slow. We propose a RLFC (Recursive least 4th order cumulant) algorithm that convergence rate is faster than the previous one.
An Entropy-Based Measurement of Certainty in Rao-Blackwellized Particle Filter Mapping (2006)

In Bayesian based approaches to mobile robot simultaneous localization and mapping, Rao-Blackwellized particle filters (RBPF) enable the efficient estimation of the posterior belief over robot poses and the map. These particle filters have been recently adopted by many exploration approaches, to whom a central issue is measuring the certainty inherent to a given estimation in order to be able to select robot actions that increase it. In this paper we propose a new certainty measurement grounded in information theory that unifies the two kinds of uncertainty which are intrinsic to SLAM: in the robot pose and in the map content. Most previous works have considered only one of them or a weighted average. Our method combines them more appropriately by first building an expected map (EM) which condenses all the current map hypotheses and then computing its mean information (MI) - an entropy derived measurement that quantifies the inconsistencies in the EM. Experimental results comparing our method (EMMI) with others verify its correctness and its better behavior for detecting the decrease in certainty when the robot enters unexplored areas and its increase after closing a loop
Large-scale demonstration test plan for digface data acquisition system (1994)

Digface characterization promotes the use of online site characterization and monitoring during waste retrieval efforts, a need that arises from safety and efficiency considerations during the cleanup of a complex waste site. Information concerning conditions at the active digface can be used by operators as a basis for adjusting retrieval activities to reduce safety risks and to promote an efficient transition between retrieval and downstream operations. Most importantly, workers are given advance warning of upcoming dangerous conditions. In addition, detailed knowledge of digface conditions provides a basis for selecting tools and methods that avoid contamination spread and work stoppages. In FY-94, work began in support of a largescale demonstration coordinating the various facets of a prototype digface remediation operation including characterization, contaminant suppression, and cold waste retrieval. This test plan describes the activities that will be performed during the winter of FY-95 that are necessary to assess the performance of the data acquisition and display system in its initial integration with hardware developed in the Cooperative Telerobotic Retrieval (CTR) program. The six specific objectives of the test are determining system electrical noise, establishing a dynamic background signature of the gantry crane and associated equipment, determining the resolution of the overall system by scanning over known objects, reporting the general functionality of the overall data acquisition system, evaluating the laser topographic functionality, and monitoring the temperature control features of the electronic package.
Direct sequence spread spectrum matched filter acquisition in frequency-selective Rayleigh fading channels (1994)

This paper presents the performance of a matched filter acquisition scheme in nonselective and frequency-selective Rayleigh fading channels. This acquisition scheme employs a reference filter to estimate the variance of the interference at the output of the detecting matched filter. Expressions for probability of detection and probability of false alarm are derived and the mean acquisition time is evaluated for various channel and system parameters. The results presented show the relationship between channel and system parameters and the system performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reliable Hydra SSD Architecture for General Purpose Controllers (2014)

The Solid State Disks (SSDs) had almost replaced the traditional Hard Disk Drives (HDDs) in modern computing systems. SSDs possess advanced features such as low power consumption, faster random access and greater shock resistance. In general, NAND Flash memories are used for bulk storage applications. This project focus on an advanced SSD architecture, called Reliable Hydra to enhance the SSD performance. Hydra SSDs overcomes the discrepancy between slow flash memory bus and fast host interfaces like SATA, SCSI, USB etc. It uses multiple high level memory controllers to execute flash memory operation without the intervention of FTL (Flash Translation Layer). It accelerates the processing of host write requests by aggressive write buffering. Memories are subjected to bit flipping errors, so this project also considers the incorporation of matrix code for increasing the reliability and hence yield of the system. The highly sophisticated controllers for real time systems in the industrial, robotics, medical and scientific applications require high performance and reliable memories. The aim of this project is to design Reliable Hydra SSD architecture for controller applications to enhance the performance. The design architecture is to be coded in VHDL using Xilinx ISE tools.
Effects of CO2 and acid gas injection on enhanced gas recovery and storage (2012)

Sequestration of CO2 and other associated waste gases in natural gas reservoirs is an option to mitigate greenhouse gases and enhanced gas recovery. This paper examines strategies to maximize enhanced gas recovery in a natural gas reservoir via subsurface storage of potential associated waste gases such as CO2 and H2S. Numerical simulations are performed with a compositional reservoir simulator ‘Tempest’ using experimental data initially produced by Clean Gas Technology Australia (CGTA) at Curtin University in 2009. The simulation results shows that additional gas is recovered by gas-gas displacement after injecting CO2 and acid gas (CO2–H2S) in two separate scenarios. Importantly, when pure CO2 is injected, CO2 breakthrough at the production well occurred faster than the breakthrough under mixed CO2–H2S injection.
Differentiation of the myoepithelial cells of the rat submandibular gland in vivo and in vitro: An ultrastructural study (1973)

Abstract Cytodifferentiation of the myoepithelial cells (MEC) of the rat submandibular gland (SMG) was observed by studying the prenatal and postnatal development of the gland in vivo and in vitro by light and electron microscopy. The anlage of the SMG first appeared on the fourteenth day of gestation and, from its earliest inception, was surrounded by an intact basal lamina. Presumptive myoepithelial cells were first seen at 18 days of gestation coinciding with the onset of secretion in the rudiment. These cells were flattened, peripherally located and subjacent to the epithelial basal lamina. Initial deposition of cytofilaments in the MEC's was observed during the first three days following birth and fully matured cells were seen as early as one week after birth. Presumptive and immature MEC's were observed undergoing mitosis, but once cytofilament deposition had begun in the cells they did not divide. Myoepithelium developed in relation to embryonic secretory structures and were only observed surounding acini and intercalated ducts in the adult gland. New myoepithelial cells were formed as long as new acinar‐intercalated duct units were formed. Myoepithelial cells did not produce secretory type granules at any time during their development or in their mature state. Development of the MEC's in vitro paralleled that in vivo and supported the above observations.
Synthesis of Serial-Fed Frequency Diverse Arrays With Periodic Triangular Frequency-Modulated Continuous Waveform (2017)

Application of serial-fed arrays as the possible candidates for frequency diverse arrays (FDAs) is discussed in this letter. Periodic sawtooth frequency-modulated continuous waveform and triangular frequency-modulated continuous waveform (TFMCW) sources are considered as the input signals. Effects of periodic functions for the frequencies of input signal are indicated on the spatial patterns compared with common FDA with increasing and decreasing frequencies of elements. A measurement setup is proposed for the serial-fed FDA with periodic TFMCW sources. Expected receiving signals at different angles are also illustrated based on spatial power patterns for TFMCW FDA. It is indicated that distances between the maximums of the received signal are changing as the functions of angle.
Percutaneous delivery of low-level laser energy reverses histamine-induced spasm in atherosclerotic Yucatan microswine. (1992)

These findings document for the first time that light-induced relaxation of vascular smooth muscle, previously documented in vitro, may be reproduced in vivo.
Performance modeling of daylight integrated photosensor-controlled lighting systems (2011)

Some building energy codes now require the incorporation of daylight into buildings and automatic photosensor-controlled switching or dimming of the electric lighting system in areas that receive daylight. This paper describes enhancements to the open-source Daysim daylight analysis software that permit users to model a photosensor control system as it will perform in a real space, considering the directional sensitivity of the photosensor , its mounting position, the space and daylight aperture geometry, window shading configuration; the electric lighting equipment and control zones; exterior obstructions; and site weather conditions. System output includes assessment of the daylight distribution in a space throughout the year, the photosensor's ability to properly track the daylight and modify electric lighting system output, and the energy savings provided by the modeled control system. The application of daylight coefficients permits annual simulations to be conducted efficiently using hourly or finer weather data time increments.
Isolation and Characterization of the Gene Associated with Geosmin Production in Cyanobacteria (2008)

Geosmin is a secondary metabolite responsible for earthy tastes and odors in potable water supplies. Geosmin continues to be a challenge to water utility management regimes and remains one of the most common causes of consumer complaints, as the taste of "dirty" water may suggest a failed disinfection regime and that the water may be unsafe to drink. Although cyanobacteria have been reported to be largely responsible for these taste and odor events, the answer as to how or why geosmin is produced has eluded researchers. We describe here for the first time the mechanism by which geosmin is produced in a model cyanobacterium, Nostoc punctiforme PCC 73102 (ATCC 29133), which we demonstrate utilizes a single enzyme to catalyze the cyclization of farnesyl diphosphate to geosmin. Using this information, we have developed a PCR-based assay that allows the rapid detection of geosmin-producing cyanobacteria. This test may be utilized to confirm and track the emergence of taste and odor-producing cyanobacteria in any given water body and thus can be used as an early warning system by managers of water bodies that may suffer from adverse taste and odor episodes.
Logistic Regression (2019)

Logistic regression is a supervised machine learning algorithm developed for learning classification problems. A classification learning problem is when the target variable is categorical. The goal of logistic regression is to map a function from the features of the dataset to the targets to predict the probability that a new example belongs to one of the target classes. Figure 20-1 is an example of a dataset with categorical targets.
Synthesis of new amphiphilic perfluoroalkylated bipyridines (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of new amphiphilic perfluoroalkylated bipyridinesNathalie Garelli and Pierre VierlingCite this: J. Org. Chem. 1992, 57, 11, 3046–3051Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/jo00037a019https://doi.org/10.1021/jo00037a019research-articleACS PublicationsRequest reuse permissionsArticle Views1765Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts