gebhart/patrepeval huggingface dataset:
A membrane-bound lectin responsive to monocytic maturation in the promyelocytic leukemia cell line HL-60. (1988)

A novel mammalian lectin activity responsive to monocytic differentiation is described in the human promyelocytic leukemia cell line HL-60. Glycoprotein binding indicates that the lectin recognizes both N-acetylneuraminic acid and galactose-terminating biantennary oligosaccharide structures. Lectin activity is independent of calcium and appears to reside in a Mr 17,000 intracellular membrane protein. Induction of wild-type HL-60 cells into their macrophage-like counterparts by 1,25-dihydroxyvitamin D3 markedly enhances lectin activity. Induction of granulocytic differentiation by retinoic acid does not affect expression of the lectin. HL-60 sublines which are resistant to granulocytic differentiation by retinoic acid, dimethylsulfoxide, or 6-thioguanine are largely deficient in orosomucoid-binding activity. Induction of monocyte/macrophage differentiation of these sublines upregulates lectin activity to the level seen in induced wild-type cells.
Extramedullary involvement in patients with acute promyelocytic leukemia: a report of seven cases. (1998)

There is some controversy as to whether treatment of APL with ATRA may predispose patients to the development of extramedullary relapse. The data from this study do not contain evidence that EMD may occur more frequently in APL patients treated with ATRA.
Synthesis of 2,5-Dihydroxy-3-(indol-3-yl)benzoquinones by Acid-Catalyzed Condensation of Indoles with 2,5-Dichlorobenzoquinone (2002)

Three methods for the conjugate addition of indoles to 2,5-dichlorobenzoquinone have been developed. A wide variety of indoles substituted with halogen, alkyl, alkoxy, and aryl groups participate in anaerobic condensation reactions promoted by HCl, H2SO4, or CH3CO2H. The hydroquinone product is partially oxidized by excess dichlorobenzoquinone and fully converted to the 2,5-dichloro-3-(indol-3-yl)benzoquinone targets by DDQ or Ag2CO3 oxidation. 2,5-Dihydroxy-3-(indol-3-yl)benzoquinones can be obtained from the dichlorides by alkaline hydrolysis. The rotational characteristics of the biaryl bond created in these reactions have been examined by theoretical and spectroscopic methods.
Impedance ratio in bioelectrical impedance measurements for body fluid shift determination (2002)

Impedance ratio is presented as an additional parameter in bioelectrical impedance measurements to ensure data reliability as well as a parameter with strong significance for the analysis of body fluid shifts.
Muscle Synergies Encoded Within the Spinal Cord: Evidence From Focal Intraspinal NMDA Iontophoresis in the Frog (2001)

This paper relates to the problem of the existence of muscle synergies, that is whether the CNS command to muscles is simplified by controlling their activity in subgroups or synergies, rather than individually. We approach this problem with two methods that have been recently introduced: intraspinal N-methyl-D-aspartate (NMDA) microstimulation and a synergy-extracting algorithm. To search for a common set of synergies encoded for by the spinal cord whose combinations would account for a large range of electromyographic (EMG) patterns, we chose, rather than examining a large range of natural behaviors, to chemically microstimulate a large number of spinal cord interneuronal sites in different frogs. A possible advantage of this complementary method is that it is task-independent. Visual inspection suggested that the NMDA-elicited EMG patterns recorded from 12 leg muscles might indeed be constructed from smaller subgroups of muscles whose activity co-varied, suggestive of synergies. We used a modification of our extracting computational algorithm whereby a nonnegative least-squares method was employed to iteratively update both the synergies and their coefficients of activation in reconstructing the EMG patterns. Using this algorithm, a limited set of seven synergies was found whose linear combinations accounted for more than 91% of the variance in the pooled EMG data from 10 frogs, and more than 96% in individual frogs. The extracted synergies were similar among frogs. Further, preferred combinations of these synergies were clearly identified. This was found by extracting smaller sets of four, five, or six synergies and fitting each synergy from those sets as a combination from the set of seven synergies extracted from the same frog; the synergy combinations from each frog were then pooled together to examine their frequency of occurrence. Concordance with this method of identifying synergy combinations was found by examining how the synergies from the set of seven correlated pair-wise as they reconstructed the EMG data. These results support the existence of muscle synergies encoded within the spinal cord, which through preferred combinations, account for a large repertoire of spinal cord motor output. These findings are contrasted with previous approaches to the problem of synergies.
Educative assessment: designing assessments to inform and improve student performance (1999)

Educative Assessment: A Vision. ESSENTIAL ELEMENTS OF ASSESSMENT. Ensuring Authentic Performance. Providing Ongoing Feedback. Promoting Student Understanding. DESIGNING ASSESSMENTS. Standards and Criteria. Individual Performance Tasks. Scoring Rubrics. APPLICATIONS AND IMPLICATIONS. Portfolio as Evidence. Curriculum and Instruction. Grading and Reporting. Teaching and Accountability. CHANGING THE SYSTEM. Feasibility: Real and Imagined. Next Steps.
Armadillo-related proteins promote lateral root development in Arabidopsis (2006)

Armadillo/beta-catenin and related proteins have important functions during animal and Dictyostelium development, regulating cell differentiation, proliferation, and adhesion. Armadillo-repeat-containing proteins also exist in plants, but the majority have unknown roles. The Arabidopsis genes that show greatest sequence homology to Armadillo/beta-catenin are called ARABIDILLO-1 and -2. Here, we demonstrate that ARABIDILLO-1 and -2 promote lateral root development. arabidillo-1/-2 mutants form fewer lateral roots, and ARABIDILLO-1-overexpressing lines produce more lateral roots than wild-type seedlings. ARABIDILLO-yellow fluorescent protein fusions are nuclear. ARABIDILLO proteins contain an F-box motif, and thus may target other proteins for proteasomal degradation. Overexpression of ARABIDILLO-1 protein fragments, including F-box fragments, in wild-type seedlings reduces lateral root formation to the level of the arabidillo-1/-2 mutant. We have shown that plant beta-catenin-related proteins regulate root development. We suggest that ARABIDILLO proteins may target an inhibitor of lateral root development for degradation and propose that Arabidopsis beta-catenin-related proteins define a previously uncharacterized pathway that promotes root branching.
Cloning of a Thermostable  -Amylase Gene from Thermomonospora curvata and Its Expression in Streptomyces lividans (1989)

The gene from Thermomonospora curvata CCM 3312 coding for thermostable alpha-amylase (tam) has been cloned in Streptomyces lividans TK 24 and localized to a 2.6 kb HindIII-BamHI fragment of DNA. The data presented here show that the tam gene is expressed at a high level in S. lividans and that the protein is efficiently excreted.
In Vitro Intrinsic Clearance-Based Optimization of<i>N</i><sup>3</sup>-Phenylpyrazinones as Corticotropin-Releasing Factor-1 (CRF<sub>1</sub>) Receptor Antagonists (2009)

A series of pyrazinone-based heterocycles was identified as potent and orally active corticotropin-releasing factor-1 (CRF(1)) receptor antagonists. Selected compounds proved efficacious in an anxiety model in rats; however, pharmacokinetic properties were not optimal. In this article, we describe an in vitro intrinsic clearance-based approach to the optimization of pyrazinone-based CRF(1) receptor antagonists wherein sites of metabolism were identified by incubation with human liver microsomes. It was found that the rate of metabolism could be decreased by incorporation of appropriate substituents at the primary sites of metabolism. This led to the discovery of compound 12x, a highly potent (IC(50) = 1.0 nM) and selective CRF(1) receptor antagonist with good oral bioavailability (F = 52%) in rats and efficacy in the defensive withdrawal anxiety test in rats.
Polyphenols from the Heartwood of<i>Cercidiphyllum japonicum</i>and their Effects on Proliferation of Mouse Hair Epithelial Cells (2002)

The methanol extract of heartwood of Cercidiphyllum japonicum (Cercidiphyllaceae) stimulated proliferation of mouse hair epithelial cells, similar to minoxidil and procyanidin B-2. (+)-Taxifolin ( 2), quercetin ( 3), myricetin ( 4), (+)-dihydromyricetin ( 5) and gallic acid ( 6) were isolated from C. japonicum and showed significant proliferative activities on the hair epithelial cells.
Simplified analysis of a polarizing optical fiber (1990)

A simplified analysis of anisotropic, polarizing fibers consisting of a circular core placed in a highly elliptical inner cladding is presented. The simplification consists of treating the problem in the scalar approximation and of letting the highly elliptical inner cladding degenerate into two semi-infinite half spaces bounded by plane surfaces. The birefringence of the fiber material is not explicitly included in the analysis. Instead, it is assumed that modes that are linearly polarized at right angles to each other 'see' effectively different isotropic media. The solution yields the field distributions and dispersion curves for guided modes right to their points of cutoff. Leakage losses of modes below cutoff are estimated with low accuracy. The results are useful for designing polarization maintaining fibers or fiber polarizers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Induction of Myelin Components: Cyclic AMP Increases the Synthesis Rate of 2′,3′‐Cyclic Nucleotide 3′‐Phosphohydrolase in C<sub>6</sub> Glioma Cells (1985)

In an effort to determine the factors that stimulate myelin synthesis, we investigated the mechanism by which dibutyryl cyclic AMP induces the activity of the myelin enzyme, 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP; EC 3.1.4.37), in C6 glioma cells. Immunotitration experiments and measurements of the accumulation of [35S]methionine-labeled CNP showed that dibutyryl cyclic AMP increased the amount of CNP in the cells but not the catalytic activity per molecule of the enzyme. Moreover, inhibition of protein synthesis with cycloheximide abolished induction of enzyme activity. Dibutyryl cyclic AMP doubled the rate of CNP synthesis but had no effect on the half-life of the enzyme (approximately 33 h). The induction was partially blocked by the inhibitors of mRNA synthesis, cordycepin or alpha-amanitin. Thus, cyclic AMP induces the synthesis of CNP.
Mass spectrometry of synthetic polymers by UV-matrix-assisted laser desorption/ionization (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass spectrometry of synthetic polymers by UV-matrix-assisted laser desorption/ionizationUte. Bahr, Andreas. Deppe, Michael. Karas, Franz. Hillenkamp, and Ulrich. GiessmannCite this: Anal. Chem. 1992, 64, 22, 2866–2869Publication Date (Print):November 15, 1992Publication History Published online1 May 2002Published inissue 15 November 1992https://pubs.acs.org/doi/10.1021/ac00046a036https://doi.org/10.1021/ac00046a036research-articleACS PublicationsRequest reuse permissionsArticle Views1853Altmetric-Citations393LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative relationships between single‐cell and cell‐population model parameters for chemosensory migration responses of alveolar macrophages to C5a (1990)

Phenomenological parameters from a mathematical model of cell motility are used to quantitatively characterize chemosensory migration responses of rat alveolar macrophages migrating to C5a in the linear under-agarose assay, simultaneously at the levels of both single cells and cell populations. This model provides theoretical relationships between single-cell and cell-population motility parameters. Our experiments offer a critical test of these theoretical linking relationships, by comparison of results obtained at the cell population level to results obtained at the single-cell level. Random motility of a cell population is characterized by the random motility coefficient, mu (analogous to a particle diffusion coefficient), whereas single-cell random motility is described by cell speed, s, and persistence time, P (related to the period of time that a cell moves in one direction before changing direction). Population chemotaxis is quantified by the chemotactic sensitivity, chi 0, which provides a measure of the minimum attractant gradient necessary to elicit a specified chemotactic response. Single-cell chemotaxis is characterized by the chemotactic index, CI, which ranges from 0 for purely random motility to 1 for perfectly directed motility. Measurements of cell number versus migration distance were analyzed in conjunction with the phenomenological model to determine the population parameters while paths of individual cells in the same experiment were analyzed in order to determine the single-cell parameters. The parameter mu shows a biphasic dependence on C5a concentration with a maximum of 1.9 x 10(-8) cm2/sec at 10(-11) M C5a and relative minima of 0.86 x 10(-8) cm2/sec at 10(-7) M C5a and 1.1 x 10(-8) cm2/sec in the absence of Ca; s and P remain fairly constant with C5a concentration, with s ranging from 2.1 to 2.5 microns/min and P varying from 22 to 32 min. chi 0 is equal to 1.0 x 10(-6) cm/receptor for all C5a concentrations tested, corresponding to 60% correct orientation for a difference of 500 bound C5a receptors across a 20 microns cell length. The maximum CI measured was 0.2. Values for the population parameters mu and chi 0 were calculated from single-cell parameter values using the aforementioned theoretical linking relationships. The values of mu and chi 0 calculated from single-cell parameters agreed with values of mu and chi 0 determined independently from population migrations, over the full range of C5a concentrations, confirming the validity of the linking equations. Experimental confirmation of such relationships between single-cell and cell-population parameters has not previously been reported.
Waveguiding and nonlinear optical properties of three-dimensional waveguides in LiTaO3 written by high-repetition rate ultrafast laser (2008)

We report the fabrication of waveguides in lithium tantalate using a 250kHz high-repetition rate ultrafast laser at 771nm and the characterization of the resulting laser induced structure with second harmonic microscopy. Waveguides operating at the 1.5μm telecommunication wavelength were formed above and below the focal volume using pulse energies ranging from 100to1.6J and translation speeds from 100μm∕sto5mm∕s. The second harmonic microscopy reveals no degradation of the electro-optic coefficient in the guiding region above the focal volume.
A multiservice high-performance packet switch for broad-band networks (1990)

An input queued packet switch for broadband networks that supports data link connections and whose capacity is not constrained by the capacity of a single packet channel is described. The switch bandwidth is allocated at two different times. At connection setup time, an output data link (a channel group) is selected on which some bandwidth is reserved for the new call. At transmission time, specific channels within the data link are optimally allocated, slot by slot, to the packets addressed to that link, solving the output channel contention at the same time. The interconnection network of the switching is basically a Batcher-banyan network including the additional networks required to handle channel groups and to allocate bandwidth fairly at transmission time. Packet sequence integrity can be guaranteed for jitter-sensitive services, as the emulation of a circuit connection. It is shown that the channel group capability of the switch greatly improves the performance of standard input queued packet switches, so that input queuing with suitable data link capacities and output queueing give comparable performances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
<title>DVD mastering using dye polymer media</title> (1997)

The Optical Disc Corporation (ODC) DRAW mastering process, which is based on dye-polymer technology, is well suited for generation of masters compliant to the DVD format and has fewer steps than that of the photoresist mastering process. Several replicas which comply to the DVD physical format were generated at 4/spl times/ standard CD data rates and mastering conditions were selected which produce all measured electrical signals within the DVD specifications (of January l996). The dye-polymer pits are smooth and are characterized by surrounding rims. The achievable electrical signals are comparable to those of photoresist technology. The smoother and less deep pits of the dye-polymer, however, permit easy release of the stamper from the molded replica with reduced probability of damaging the replica pits. This, in conjunction with the closed-loop control of the DRAW mastering system, allows for a DVD mastering process with high throughput and yield.
[Influence on menstrual function of women exposed to occupational stress and its mechanism]. (2006)

据报道,2000年我国女性从业人员已过3亿,占社会总从业人员的44.96%,高于世界平均水平[1].由于职业女性担负着事业和家庭的双重任务,经常工作家庭两班倒,任务重、压力较大,易产生心理应激[2].研究表明,各种各样的环境应激如生活和工作暴露均可干扰女性内分泌功能,影响女性的生殖内分泌,危害女性的生殖健康和月经功能[3,4]。
Spatial light modulation using electroabsorption in a GaAs charge-coupled device (1982)

High-speed one- and two-dimensional spatial light modulation may be carried out using the electroabsorption (Franz-Keldysh) effect in a GaAs buried-channel charge-coupled device (CCD). For photon energies slightly lower than the energy gap, the transmission through or along the surface of a CCD structure may be controlled by the signal charge in the wells, through the change of electric field with charge. The modulator is thus electrically addressable and it promises optical quality sufficient for coherent applications. Experimental measurements on a specially designed GaAs CCD structure with semitransparent gates have verified the predicted performance.
Documenting motion sequences with a personalized annotation system (2006)

We present a novel technique for motion annotation that adapts to a person's style and vocabulary of basic movements (gestures). The system segments continuous motion sequences into gestures, which it then documents in a personalized annotation with an intuitive hierarchical representation. Initial testing suggests that software based on this technique could be an effective teaching aid for dance and sports.
The Brazilian Tunable Filter Imager for the SOAR Telescope (2013)

The Brazilian Tunable Filter Imager for the SOAR Telescope, Cláudia Mendes de Oliveira, Keith Taylor, Bruno Quint, Denis Andrade, Fabrício Ferrari, Rene Laporte, Giseli de A. Ramos, Christian Dani Guzman, Luiz Cavalcanti, Alvaro de Calasans, Javier Ramirez Fernandez, Edna Carolina Gutierrez Castañeda, Damien Jones, Fernando Luis Fontes, Ana Maria Molina, Fábio Fialho, Henri Plana, Francisco J. Jablonski, Luiz Reitano, Olivier Daigle, Sergio Scarano, Philippe Amram, Philippe Balard, Jean-Luc Gach, Claude Carignan
Silicon Melt, Regrowth, and Amorphization Velocities During Pulsed Laser Irradiation (1983)

Direct experimental measurements of the melt-in, resolidification, and amorphization velocities for pulsed (2.5 to 10 ns) uv and ruby-laser irradiation have been made on $〈100〉$ silicon on sapphire. An experimental value for the critical amorphization velocity in $〈100〉$ Si has been measured as 15 m/s. Epitaxial resolidification was observed from 5 to 15 m/s. Additionally, melt-in velocities in excess of 200 m/s were observed for 2.5-ns ruby irradiation.
Rigidity, computation, and randomization in network localization (2005)

We provide a theoretical foundation for the problem of network localization in which some nodes know their locations and other nodes determine their locations by measuring the distances to their neighbors. We construct grounded graphs to model network localization and apply graph rigidity theory to test the conditions for unique localizability and to construct uniquely localizable networks. We further study the computational complexity of network localization and investigate a subclass of grounded graphs where localization can be computed efficiently. We conclude with a discussion of localization in sensor networks where the sensors are placed randomly.
Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rsk<sup>mo</sup>‐2 (1993)

An improved procedure has been developed for the isolation of insulin-stimulated protein kinase-1 (ISPK-1), an S6 kinase-II homologue, by which 0.5 mg highly purified enzyme can be obtained within four days. The sequences of tryptic peptides from ISPK-1 (100 residues) revealed 100% identity with the predicted protein product of rskmo-2, a cDNA clone isolated from a mouse F2 cell line library [Alcorta, D. A., Crews, C. M., Sweet, L. J., Bankston, L., Jones, S. W. and Erikson, R. L. (1989) Mol. Cell. Biol. 9, 3850-3859], demonstrating that rskmo-2 encodes an S6 kinase-II. Two isoforms of mitogen-activated protein (MAP) kinase (p42mapk and p44mapk) were the only ISPK-1-reactivating enzymes detected after Mono Q chromatography of extracts prepared from rabbit skeletal muscle or phaeochromocytoma 12 cells stimulated by nerve or epidermal growth factors. One of the residues on ISPK-1 phosphorylated by p42mapk was a threonine located nine residues N-terminal to the conserved Ala-Pro-Glu motif in the C-terminal protein kinase domain, an analogous location to phosphorylation sites essential for the activity of cAMP-dependent protein kinase, MAP kinase and p34cdc2. A further threonine located five residues N-terminal to the same Ala-Pro-Glu motif was also phosphorylated, probably via autophosphorylation catalysed by ISPK-1 itself.