gebhart/patrepeval huggingface dataset:
Novel Oxidative Transformation of Indenoisoquinolines to Isoquinoline-3-spiro-3‘-phthalides in the Presence of Osmium Tetraoxide and 4-Methylmorpholine <i>N</i>-Oxide (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel Oxidative Transformation of Indenoisoquinolines to Isoquinoline-3-spiro-3'-phthalides in the Presence of Osmium Tetraoxide and 4-Methylmorpholine N-OxideMuthusamy Jayaraman, Phillip E. Fanwick, and Mark CushmanView Author Information Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, and Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 Cite this: J. Org. Chem. 1998, 63, 17, 5736–5737Publication Date (Web):July 29, 1998Publication History Received19 May 1998Published online29 July 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/jo980928yhttps://doi.org/10.1021/jo980928yrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views537Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Carbonyls,Chemical reactions,Chemical structure,Hydrocarbons,Osmium Get e-Alerts
69.1: <i>Invited Paper</i> : Solution Processing of Small‐Molecule OLEDs (2007)

Abstract Solution processing can significantly reduce the manufacturing cost of OLED displays by reducing material consumption and allowing OLED manufacturing to be scaled to large motherglass sizes. Recent developments allow OLEDs to be manufactured using solution processing of small molecule OLED materials, thus enabling low cost manufacturing of high performance OLED displays.
Compressor trees for decimal partial product reduction (2008)

Decimal multiplication has grown in interest due to the recent announcement of new IEEE 754R standards and the availability of high-speed decimal computation hardware. Prior research enabled partial products to be coded more efficiently for their use in radix 10 architectures. This paper clarifies previous techniques for partial product reduction using carry-save adders and presents a new 4:2 compressor structure. This new structure improves performance at the expense of more gates, however, regularity is introduced into the circuit to promote implementations in Very Large Scale Integration (VLSI) Designs. Results are presented and compared for several designs using a TSMC SCN6M $0.18 mu m feature size.
Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020)

As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), abidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. However, the efficacy and safety of these drugs for 2019- nCoV still need to be further confirmed by clinical experiments.
Pleading under the Federal Rules (1958)

This is indeed a very gracious reception, but I knew I would have a warm response from you. I was assured just this week by my colleagues Judges Medina and Kaufman that they envied me, for they had had such a pleasant time out here. So I am the bringer of greetings from them to many of you individually and all of you collectively in recollection of their visit with you to recently. Of course, I feel I have other ties with Laramie. Bob Hamilton has spoken of the time when he was a student at Yale. One of life's enduring satisfactions for having been a teacher is to go around the country and see one's students in various places of responsibility. I would like to stop to brag about that--to refer, for instance, to my student the Mayor of New York, my student the Mayor of Philadelphia, my student who has just retired as Attorney General of the United States, my student who is Governor of Massachusetts, and my student who almost became Vice President. I will say, however, that I do feel almost at home in Laramie, because my dear friend and colleague of many years' standing, Thurman Arnold, was the Mayor of Laramie and always claimed that he was the only Elk on the Yale faculty. Another one of the Yale men we had from here was Dean Carl Arnold, a truly wonderful person.
Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retina (2007)

Sphingosine 1-phosphate (S1P), a multifunctional lipid mediator that signals via the S1P family of G protein-coupled receptors (S1PR), regulates vascular maturation, permeability, and angiogenesis. In this study, we explored the role of S1P 2 receptor (S1P2R) in normal vascularization and hypoxia-triggered pathological angiogenesis of the mouse retina. S1P2R is strongly induced in ECs during hypoxic stress. When neonatal mice were subjected to ischemia-driven retinopathy, pathologic neovascularization in the vitreous chamber was suppressed in S1p2-/- mice concomitant with reduction in endothelial gaps and inflammatory cell infiltration. In addition, EC patterning and normal revascularization into the avascular zones of the retina were augmented. Reduced expression of the proinflammatory enzyme cyclooxygenase-2 (COX-2) and increased expression of eNOS were observed in the S1p2-/- mouse retina. S1P2R activation in ECs induced COX-2 expression and suppressed the expression of eNOS. These data identify the S1P2R-driven inflammatory process as an important molecular event in pathological retinal angiogenesis. We propose that antagonism of the S1P2R may be a novel therapeutic approach for the prevention and/or treatment of pathologic ocular neovascularization.
Engineering Acyclic Stereocontrol in the Alkylation of Vinylglycine-Derived Dianions:  Asymmetric Synthesis of Higher α-Vinyl Amino Acids (2000)

A generalizable synthesis of higher L-alpha-vinyl amino acids is presented. The strategy pursued here involves the introduction of the amino acid side chain via the alkylation of a chiral, vinylglycine-derived dianionic dienolate, bearing the (-)-8-(beta-naphthyl)menthyl (d'Angelo) auxiliary. A model is presented that postulates a favored "exo-entended" conformation for this dienolate, leading to C(alpha)-alkylation at the si face. The model invokes internal amidate chelation to control ester enolate geometry and soft-soft interactions between the polarizable beta-naphthyl ring of the auxiliary and the extended pi-system of the dienolate to shield the re face. Heats of formation for four conformers of this dianion were calculated for their semiempirical optimized geometries (PM3). The results support the notion that in these vinylglycine-derived dianionic dienolates, "exo" conformations are considerable lower in energy than their "endo" counterparts, with the "exo-entended" conformation being most favorable. In fact, the d'Angelo auxiliary gives a greater degree of acyclic stereocontrol in this system when compared with the (-)-8-phenylmenthyl (Corey) and trans-2-(beta-naphthyl)cyclohexyl auxiliaries, using isobutyl iodide and benzyl bromide as model electrophiles. These dianions are generated from the corresponding dehydrobutyrine esters via sequential deprotonation with LDA and n-BuLi (2 equiv). When alkylations are carried out at -78 degrees C in THF-HMPA, they proceed in 65-81% yields, with both regiocontrol (deconjugative alpha-alkylation is preferred over gamma-alkylation) and a great degree of acyclic stereocontrol [91:9 to >/=98:2 diastereomeric ratios (10 examples)]. The auxiliary may be recovered in high yield (generally 90%) using a modification of Gassman's "anhydrous hydroxide" conditions, in which considerably higher temperatures are employed. Among the side chains introduced directly are those of butyrine, leucine, ornithine, phenylalanine, aspartate, valine, and norvaline. The lysine side chain is elaborated via a 4-step sequence from the alkylation product obtained with 1-chloro-4-iodobutane as electrophile. Importantly, to our knowledge, this work represents the first asymmetric synthesis of L-alpha-vinyl analogues of m-tyrosine, ornithine, and lysine, known time-dependent inhibitors for amino acid decarboxylases.
Cryoplasty for the Treatment of Femoropopliteal Arterial Disease: Extended Follow-up Results (2006)

Long-term data indicate that cryoplasty is a durable therapy, with relatively low long-term restenosis rates compared to other endovascular treatment approaches.
A concept of communication distance and its application to six situations in mobile environments (2005)

Wireless networks combined with location technology create new problems and call for new decision aids. As a precursor to the development of these decision aids, a concept of communication distance is developed and applied to six situations. This concept allows travel time and bandwidth to be combined in a single measure so that many problems can be mapped onto a weighted graph and solved through shortest path algorithms. The paper looks at the problem of intercepting an out-of-communication team member and describes ways of using planning to reduce communication distance in anticipation of a break in connection. The concept is also applied to ad hoc radio networks. A way of performing route planning using a bandwidth map is developed and analyzed. The general implications of the work to transportation planning are discussed.
Implementasi Steganografi Menggunakan Metode Least Significant Bit dan Kriptografi Advanced Encryption Standard (2012)

Nowadays, the development of celluler device especially mobile phone is very rapid. The security of information in mobile phone becoming such an important thing, because users do not want other people can access their essential information. It means in the security in mobile phone. One way to secure the data is steganograpgy technique. This technique hides the data in a digital media. In this research the steganography technique that the is used is the Least Significant Bit (LSB) which implemented to cellular equipment with android as the operating system. The digital image which is used to hide the data is PNG. The test result shows that steganography has been implemented successfully in android phone. In the imprecebility aspect, user cannot different between the picture with message and the original picture bare eyedly. In recovery aspect, the message successfully encrypted and decrypted without changing the original content of the message. The lack occurs in fidelity aspect which the expansion of PNG file happens. Index Terms”LSB, least significant bit, png, android, handphone
Efficient synthesis of quantum circuits implementing clifford group operations (2014)

Quantum circuits established themselves as a promising emerging technology and, hence, attracted considerable attention in the domain of computer-aided design. As a result, many approaches for synthesis of corresponding netlists have been proposed in the last decade. However, as the design of quantum circuits faces serious obstacles caused by phenomena such as superposition, entanglement, and phase shifts, automatic synthesis still represents a significant challenge. In this paper, we propose an automatic synthesis approach for quantum circuits that implement Clifford Group operations. These circuits are essential for many quantum applications and cover core aspects of quantum functionality. The proposed approach exploits specific properties of the unitary transformation matrices that are associated to quantum operations. Furthermore, Quantum Multiple-Valued Decision Diagrams (QMDDs) are employed for an efficient representation of these matrices. Experimental results confirm that this enables a compact realization of the respective quantum functionality.
Caribbean-Latin@s: A Crisscrossing and Dislocating Narrative (2014)

Anthurium: A Caribbean Studies Journal includes scholarship on the work of visual artists, commentary on current issues in Caribbean studies and travelogues. Anthurium remains committed to bridging the digital divide by making peer reviewed, scholarly articles and creative writing available to teachers, students, scholars and persons interested in Caribbean literature and culture worldwide without fee based subscriptions. We would like to thank those of you who continue to support refereed, open access academic e-journals such as ours.
Exploring Human Metabolites Using the Human Metabolome Database (2009)

The Human Metabolome Database (HMDB) is a Web-based bioinformatic/cheminformatic resource with detailed information about human metabolites and metabolic enzymes. It can be used for fields of study including metabolomics, biochemistry, clinical chemistry, biomarker discovery, medicine, nutrition, and general education. In addition to its comprehensive literature-derived data, the HMDB contains an extensive collection of experimental metabolite concentration data for plasma, urine, CSF, and/or other biofluids The HMDB is fully searchable, with many tools for viewing, sorting and extracting metabolite names, chemical structures, biofluid concentrations, enzymes, genes, NMR or MS spectra, and disease information. Each metabolite entry in the HMDB contains an average of 90 separate data fields including a comprehensive compound description, names and synonyms, chemical structure information, physico-chemical data, reference NMR and MS spectra, normal and abnormal biofluid concentrations, tissue locations, disease associations, pathway information, enzyme data, gene sequence data, and SNP and mutation data, as well as extensive links to images, references and other public databases.
Observation of inverse U-shaped profiles after platinum diffusion in silicon (1991)

Inverse U-shaped profiles of platinum in silicon were obtained after diffusion at 700 °C. Deep level transient spectroscopy was used to determine the platinum concentrations in various depths of the samples. In the bulk, a higher concentration of platinum was found than at the surface. Therefore, these platinum profiles are called ‘‘inverse U-shaped profiles.’’ These diffusion profiles can be described by the Frank–Turnbull mechanism, assuming that the initial concentration of vacancies is higher than their equilibrium concentration. Therefore, the observation of inverse U-shaped profiles after platinum diffusion may serve as the evidence that diffusion processes, which involve vacancies, are determined in the bulk by the initial vacancy concentration and not by the vacancy equilibrium concentration at temperatures of ∼850 °C and below.
Pharmacodynamics, Safety, and Pharmacokinetics of BMS-663068, an Oral HIV-1 Attachment Inhibitor in HIV-1-Infected Subjects (2012)

Administration of BMS-663068 for 8 days with or without ritonavir resulted in substantial declines in plasma HIV-1 RNA levels and was generally well tolerated. Longer-term clinical trials of BMS-663068 as part of combination antiretroviral therapy are warranted. Clinical Trials Registration.NCT01009814.
Is the bang worth the buck? A RAID performance study (1996)

Expecting a high data delivery rate as well as data protection, the Lister Hill National Center for Biomedical Communications procured a RAID system to house image files for image delivery applications. A study was undertaken to determine the configuration of the RAID system that would provide for the fastest retrieval of image files. Average retrieval times with single and with concurrent users were measured for several stripe widths and several numbers of disks for RAID levels 0, 0+1 and 5. These are compared to each other and to average retrieval times for non-RAID configurations of the same hardware. Although the study in ongoing, a few conclusions have emerged regarding the tradeoffs among the different configurations with respect to file retrieval speed and cost.
Neurotoxicity studies (2008)

農薬などの化学物質の安全性評価の分野では，脳神経系の機能，形態，発達への影響を体系的に評価するガイドラインが整備されている．その特徴は，一般毒性試験を1次スクリーニング試験と位置づけ，成獣期ならびに発達期のガイドラインを揃えることによって，脳神経系への影響を段階的に評価することにある．本稿では，神経毒性に関連するガイドラインを紹介し，世界的な標準であるOECDガイドラインに基づいて哺乳動物を対象にした神経毒性試験を解説した．
Compact dual-band PIFA with multi-resonators (2002)

A newly designed dual-band planar inverted-F antenna with three radiating resonators for use in mobile phone devices is presented. A high frequency structure simulator is used to verify the antenna, which operates at the GSM-900 and DCS-1800 bands. Measurements made in real-life conditions to test how the plastic case and user handing influence the performance of the device demonstrate that the bandwidths are larger than those in similar devices reported in the previous literature.
Quasi-synchronous checkpointing: Models, characterization, and classification (1999)

Checkpointing algorithms are classified as synchronous and asynchronous in the literature. In synchronous checkpointing, processes synchronize their checkpointing activities so that a globally consistent set of checkpoints is always maintained in the system. Synchronizing checkpointing activity involves message overhead and process execution may have to be suspended during the checkpointing coordination, resulting in performance degradation. In asynchronous checkpointing, processes take checkpoints without any coordination with others. Asynchronous checkpointing provides maximum autonomy for processes to take checkpoints; however, some of the checkpoints taken may not lie on any consistent global checkpoint, thus making the checkpointing efforts useless. Asynchronous checkpointing algorithms in the literature can reduce the number of useless checkpoints by making processes take communication induced checkpoints besides asynchronous checkpoints. We call such algorithms quasi-synchronous. In this paper, we present a theoretical framework for characterizing and classifying such algorithms. The theory not only helps to classify and characterize the quasi-synchronous checkpointing algorithms, but also helps to analyze the properties and limitations of the algorithms belonging to each class. It also provides guidelines for designing and evaluating such algorithms.
Metal Allergy and Systemic Contact Dermatitis: An Overview (2012)

Contact dermatitis is produced by external skin exposure to an allergen, but sometimes a systemically administered allergen may reach the skin and remain concentrated there with the aid of the circulatory system, leading to the production of systemic contact dermatitis (SCD). Metals such as nickel, cobalt, chromium, and zinc are ubiquitous in our environment. Metal allergy may result in allergic contact dermatitis and also SCD. Systemic reactions, such as hand dermatitis or generalized eczematous reactions, can occur due to dietary nickel or cobalt ingestion. Zinc-containing dental fillings can induce oral lichen planus, palmoplantar pustulosis, and maculopapular rash. A diagnosis of sensitivity to metal is established by epicutaneous patch testing and oral metal challenge with metals such as nickel, cobalt, chromium, and zinc. In vitro tests, such as the lymphocyte stimulating test (LST), have some advantages over patch testing to diagnose allergic contact dermatitis. Additionally, the determination of the production of several cytokines by primary peripheral blood mononuclear cell cultures is a potentially promising in vitro method for the discrimination of metal allergies, including SCD, as compared with the LST.
Throughput Performance of Downlink MIMO Transmission with Multi-Beam Selection using a Novel Codebook (2007)

We have been proposing multi-beam MIMO (MB-MIMO) as an evolved UTRA downlink MIMO scheme for 3GPP long term evolution (LTE). MB-MIMO is a pre-coding MIMO scheme that uses a simple combination of multi-beam multiple-data-stream transmission and user equipment (UE)-based adaptive beam selection. The scheme benefits from its simple uplink feedback signaling, because MB-MIMO requires only a subset of the beam (codebook) indices to be fed back. However, a hardware calibrator (HW-CAL), which increases the complexity of RF components at a transmitter, should be installed in order to achieve a high beam-forming gain with a small codebook size. In this paper, we propose a novel codebook design for MB-MIMO, which realizes a superior performance without any HW-CAL with a small increase of the codebook size and the feedback signaling. We performed a computer simulation to evaluate the throughput performance of the proposed scheme, considering the phase variation between antenna elements in a spatially distributed multi-path fading channel model.
Using Constraint Programming to Manage Configurations in Self-Adaptive Systems (2012)

Combining goal-modeling techniques with constraint programming provides the means to identify the variants best suited to the environmental contexts that a self-adaptive software system might encounter at runtime.
Lysophosphatidic Acid and Its Role in Reproduction (2002)

Lysophosphatidic acid (LPA) belongs to a new family of lipid mediators that are endogenous growth factors and that elicit diverse biological effects, usually via the activation of G protein-coupled receptors. LPA can be generated after cell activation through the hydrolysis of preexisting phospholipids in the membranes of stimulated cells. A dramatic elevation of LPA levels was found in serum of patients suffering from ovarian carcinoma. Because these high LPA amounts can be detected as early as stage I of the disease, LPA has been introduced as a new marker for ovarian cancer. Progression of the malignancy is correlated with a differential expression of various LPA receptor subtypes. The presence of LPA in the follicular fluid of healthy individuals implicates that this biological mediator may be relevant to normal ovarian physiology. LPA induces proliferation and mitogenic signaling of prostate cancer cells, and a novel LPA receptor isoform has been recognized in healthy prostate tissues. This evidence indicates multiple roles for LPA in both male and female reproductive physiology and pathology. In this review, we summarize the literature on LPA generation, the way it is degraded, and the mechanisms by which signals are transduced by various LPA receptors in reproductive tissues, and we discuss possible future research directions in these areas.