gebhart/patrepeval huggingface dataset:
Adverse Cardiac Effects of Acute Alcohol Ingestion in Young Adults (1985)

Previous studies of the effects of acute alcohol ingestion in normal subjects have used measures of left ventricular performance that are altered by changes in preload and afterload and in contractile state. In studies involving nine healthy, young adults, we measured sensitive load-independent end-systolic indices of left ventricular contractility over a wide range of pressures generated by methoxamine infusion before and after oral alcohol administration. Echocardiography was used in conjunction with calibrated carotid pulse tracings. Alcohol ingestion resulted in a fall (p less than 0.01) in left ventricular end-diastolic dimension (a measure of preload), end-systolic wall stress (a measure of afterload), and systemic vascular resistance, while not changing the left ventricular shortening fraction. In contrast, the end-systolic pressure-dimension slope decreased (p less than 0.001) and the rate-corrected velocity of left ventricular fiber shortening at an end-systolic wall stress of 50 g/cm2 fell (p less than 0.001). Thus, when load-independent assessment of left ventricular contractility is done, acute alcohol ingestion has a myocardial depressant effect greater than previously suspected.
Time Series: Data Analysis and Theory. (1976)

This book will be most useful to applied mathematicians, communication engineers, signal processors, statisticians, and time series researchers, both applied and theoretical. Readers should have some background in complex function theory and matrix algebra and should have successfully completed the equivalent of an upper division course in statistics.
Web-Based Training for Native American Tribes (2004)

The authors describe a project undertaken at the School of Hotel and Restaurant Management at Northern Arizona University in which the internet is used to present Native American tribes in Arizona with customer service training. It discusses why the project was instigated looks at its development and funding, and highlights the educational and technological challenges that had to be overcome. This is the second in a series of articles on the uses of the internet in educating non-university student constituencies interested in hospitality management.'
A delicate issue (2000)

article Free Access Share on A delicate issue: what to do when the state of the practice leads the state of the art Author: Robert L. Glass Computing Trends Computing TrendsView Profile Authors Info & Claims ACM SIGMIS Database: the DATABASE for Advances in Information SystemsVolume 31Issue 3Summer 2000 pp 5–7https://doi.org/10.1145/381823.381827Online:01 June 2000Publication History 0citation117DownloadsMetricsTotal Citations0Total Downloads117Last 12 Months3Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Optimization of a Model of Full-Thickness Epidermal Burns in the Pig and Immunohistochemical Study of Epidermodermal Junction Regeneration during Burn Healing (1992)

In order to obtain a wound model in which healing involved epidermis rebuilding and epidermodermal junction (EDJ) regeneration without involvement of any dermal repair, we optimized a previous model of experimental cutaneous burning with an aluminum bar by testing various conditions of burning associated with different pre- and postburn skin treatments. On the optimized model of full-thickness epidermal burns without any dermal injury, we investigated the kinetics of regeneration of 4 EDJ components, from day 2 to day 23 after burning. The epidermal healing was studied by light microscopy and EDJ regeneration by indirect immunofluorescence with one bullous pemphigoid (BP) serum, antisera to fibronectin and to type IV collagen (Coll IV) and the monoclonal antibody 4C 12-8 to laminin. Histologically, neoepidermis, detected from day 2, appeared as a reepidermization tongue which progressed from the burn edges between the overlying necrotic burned epidermis and the underlying uninjured dermis. Epidermis continuity was found to be restored at day 9. Immunohistochemically, labelling of BP antigen (BPA), Coll IV and laminin extended all along the neo-EDJ, from day 2 to day 23. In contrast, fibronectin labelling was detected only in the proximal and median portions of the neo-EDJ before day 7, then all along the neo-EDJ, from day 7 to day 23. For all the components except Coll IV, the intensity of the labelling beneath the neoepidermis was higher than that of the residual labelling remaining under the necrotic epidermis. Therefore, BPA and laminin regenerated synchronously to neoepidermis whereas fibronectin first regenerated with delay, then synchronously.(ABSTRACT TRUNCATED AT 250 WORDS)
Triton‐induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs (1972)

Abstract We describe a screening test for hypolipidemic agents in which compounds are administered orally to fasted rats after a single intravenous injection of 225 mg Triton WR‐1339/kg and serum cholesterol and triglycerides are measured 43 hr post‐Triton. Conditions for the screen were established by studying interrelationships between serum cholesterol, triglycerides and Triton levels during the post‐Triton period and the effects of Triton dose, route of administration and fasting on serum lipid levels and drug hypocholesterolemic activity. The test detects compounds which inhibit lipid biosynthesis or stimulate lipid catabolism. Several drugs with different mechanisms of action which are hypolipidemic in man, including nicotinic acid, D ‐thyroxine, triparanol, nafoxidine HCl and clofibrate are active in this system. Results with standard hypolipidemic agents are reproducible and conform well to performance levels of the screen predicted from statistical analysis.
Insulin Resistance and Increased Leptin Concentrations in Noncompliant Schizophrenia Patients but Not in Antipsychotic-Naive First-Episode Schizophrenia Patients (2004)

The results reported in this study suggest the effect of previous antipsychotic treatment on glucose metabolism parameters and weight-related hormones such as leptin, while ruling out a preexisting impairment of glucose metabolism in never-medicated first-episode schizophrenic patients.
Behavior of BAW devices at high power levels (2005)

Bulk acoustic wave (BAW) and FBAR technologies offer key advantages for transmit filters which are used between the power amplifier and antenna in cell phone applications. The classical challenge for Tx filters in duplexers is to achieve low insertion loss, high return loss, high Rx - Tx isolation and good wideband performance at the same time. The trade-offs between those parameters can be modeled in a straightforward approach as will be briefly described. The main section of this paper discusses 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> order effects which become relevant at high power levels. The energy loss in each individual BAW resonator generates a shift and spread of resonance frequencies in the filter elements by self-heating effects. These effects can cause unexpected performance issues and may even lead to thermal instability. A concept for modeling of self-heating effects is presented in detail. The role of self-heating with regard to power-handling capability of a filter will be pointed out. As a consequence of extreme energy density at high power levels a certain degree of non-linear effects can be observed in BAW/FBAR filters. The origin of these effects will be discussed as well as a modeling strategy. This is in particular important for emerging W-CDMA applications of BAW and FBAR filters.
Control of Population Inversion in Pulsed Optical Masers by Feedback Modulation (1962)

The output power level of an optical maser is dependent on the level of inversion which can be reached. Using a technique in which the optical feedback is modulated by a shutter disk, an enhancement of the output power level of a pulsed ruby optical maser was observed. The higher level of output power occurred for only a short pulse. An explanation is given and the observed effect compared to the expected value.
<title>Application of infrared imaging for non-contact measurements of thermal diffusivity in tissue</title> (2000)

We demonstrate application of an IR imaging technique for non-contact determination of thermal diffusivity of biological materials. The IR method utilizes pulsed laser excitation to produce an initial 3D temperature distribution in tissue, and records IR images of subsequent heat diffusion. The theoretical model assumes the time-dependent temperature increase following pulsed laser exposure occurs due to independent heat diffusion in longitudinal and lateral directions. A nonlinear least-squares algorithm is used to compute the lateral point spread function for a pair of recorded IR images and determine thermal diffusivity of a test specimen. Application of the method was demonstrated using tissue phantom s and ex-vivo samples of hydrated cartilage.
Substituted Sulfanilamides. III. N<sup>4</sup>-Acyl-N<sup>1</sup>-hydroxy Derivatives (1940)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted Sulfanilamides. III. N4-Acyl-N1-hydroxy DerivativesMaurice L. Moore, Charles S. Miller, and Ellis MillerCite this: J. Am. Chem. Soc. 1940, 62, 8, 2097–2099Publication Date (Print):August 1, 1940Publication History Published online1 May 2002Published inissue 1 August 1940https://pubs.acs.org/doi/10.1021/ja01865a052https://doi.org/10.1021/ja01865a052research-articleACS PublicationsRequest reuse permissionsArticle Views251Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Purification and Characterization of Maleate Hydratase from <i>Pseudomonas pseudoalcaligenes</i> (1993)

Maleate hydratase (malease) from Pseudomonas pseudoalcaligenes has been purified. The purified enzyme (98% pure) catalyzes the stereospecific addition of water to maleate and citraconate (2-methylmaleate), forming d-(+)-malate and d-(+)-citramalate, respectively. 2,3-Dimethylmaleate was also a substrate for malease. The stability of the enzyme was dependent on the protein concentration and the addition of dicarboxylic acids. The purified enzyme (89 kDa) consisted of two subunits (57 and 24 kDa). No cofactor was required for full activity of this colorless enzyme. Maximum enzyme activity was measured at pH 8 and 45 degrees C. The K(m) for maleate was 0.35 mM, and that for citraconate was 0.20 mM. Thiol reagents, such as p-chloromercuribenzoate and iodoacetamide, and sodium dodecyl sulfate completely inhibited malease activity. Malease activity was competitively inhibited by d-malate (K(i) = 0.63 mM) and d-citramalate (K(i) = 0.083 mM) and by the substrate analog 2,2-dimethylsuccinate (K(i) = 0.025 mM). The apparent equilibrium constants for the maleate, citraconate, and 2,3-dimethylmaleate hydration reactions were 2,050, 104, and 11.2, respectively.
Kinematics for Constrained Continuum Robots Using Wavelet Decomposition (2000)

Over the past several years, there has been a rapidly expanding interest in the study and construction of a new class of robot manipulators which utilize high degree of freedom, or continuous, backbone structures. In this paper, we consider some basic properties of these "continuum" or "hyper-redundant" robots. We base our analysis around remotely-driven, tendon-actuated manipulators such as the Rice/Clemson "Elephant's Trunk". We briefly discuss the kinematic model, before detailing how to approach the inverse kinematics for a planar continuum robot by decomposition into either a natural or a wavelet basis. We also examine how a wavelet decomposition method can help resolve redundancy in a planar continuum robot.
The effects of cancer chemotherapeutic agents on normal hematopoietic precursor cells: a review. (1976)

The effects of antineoplastic agents, singly or in combination, on normal hematopoietic precursor cells have been reviewed. Following a description of the assays used (e.g., spleen colony, in vitro colony, repopulating ability), the dose response and/or time response for each drug are presented by species and by assay as available. The schedule of drug administration, the time of the assay, and the proliferative state of the target population are the most important determinants. Alkylating agents, antitumor antibiotics, and 5-fluorouracil have exponential dose survival curves. "Phase-specific" agents such as antimetabolites, Vinca alkaloids, and ribonucleotide reductase inhibitors have plateaus in their dose survival curves, although the level of this plateau is different for different agents. Most drugs are more effective against rapidly proliferating cells although busulfan is less effective. Direct interspecies comparisons are possible with some of the clonogenic assays, which may allow prediction of the magnitude of human hematological toxicity for new agents or combinations.
Combined Effects of Low-dose Oral Spironolactone and Captopril Therapy in a Rat Model of Spontaneous Hypertension and Heart Failure (2003)

The effects of low-dose oral spironolactone (SPIRO) in a rat model of hypertensive heart failure (spontaneously hypertensive heart failure rat) were compared with its effects when combined with captopril (CAP). Twenty-six spontaneously rats with hypertensive heart failure were treated with either placebo (CON), SPIRO (20 mg/kg/d by mouth), CAP (100 mg/kg/d by mouth), or both SPIRO and CAP for 12 weeks. This dose of oral SPIRO did not affect blood pressure, left ventricular end-diastolic diameter, left ventricular ejection fraction, plasma atrial natriuretic peptide concentration, or cardiac fibrosis; however, in combination with CAP, it exerted a significant depressor effect after 12 weeks of treatment that was accompanied by increased urine output and decreased urinary protein excretion. These effects were significantly greater than those with CAP treatment alone. A significant increase in plasma aldosterone level was observed only in CON (174 +/- 21%). These data suggest that the addition of low-dose SPIRO to angiotensin I-converting enzyme inhibitor treatment may prevent progression into end-stage congestive heart failure through synergistic effects on diuresis and renoprotection.
Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation. (1998)

Carbon monoxide (CO) derived from heme oxygenase has recently been shown to play a role in controlling hepatobiliary function, but intrahepatic distribution of the enzyme is unknown. We examined distribution of two kinds of the heme oxygenase isoforms (HO-1 and HO-2) in rat liver immunohistochemically using monoclonal antibodies. The results showed that distribution of the two isoforms had distinct topographic patterns: HO-1, an inducible isoform, was observed only in Kupffer cells, while HO-2, a constitutive form, distributed to parenchymal cells, but not to Kupffer cells. Both isoforms were undetectable in hepatic stellate cells and sinusoidal endothelial cells. Of the two isoforms, HO-2 in the parenchymal cell rather than HO-1 in the Kupffer cell, appears to play a major role in regulation of microvascular tone. In the perfused liver, administration of HbO2, a CO-trapping reagent that can diffuse across the fenestrated endothelium into the space of Disse, elicited a marked sinusoidal constriction, while administration of a liposome-encapsulated Hb that cannot enter the space had no effect on the microvascular tone. These results suggest that CO evolved by HO-2 in the parenchymal cells, and, released to the extrasinusoidal space, served as the physiological relaxant for hepatic sinusoids.
Prospects for Composts and Biocontrol Agents as Substitutes for Methyl Bromide in Biological Control of Plant Diseases (1999)

Methyl bromide, an effective soil fumigant for control of soilborne plant pathogens, is scheduled to be phased out by 2005 because of its negative impacts on the environment. Many chemical alternatives to methyl bromide have been proposed but so far, none have proved as effective. Composts have long been recognized to provide a degree of control of diseases caused by soilborne plant pathogens. For this reason, disease-suppressive effects of composts have been investigated intensively over the past two decades. Many compost quality factors must be controlled to obtain consistent effects with these organic amendments. The composition of the organic matter from which the compost is prepared, the composting process itself, the stability or maturity of the compost, the quantity of available plant nutrients provided by the compost, loading rates, time of application, and other factors all must be controlled. These and other factors are reviewed in this paper. Despite these difficulties, the use of compost for disease control is increasing rapidly. The nursery industry for decades has taken advantage of this benefit associated with compost utilization.
All Solid State Red, Green, and Blue Pr:YLF Laser (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. C. Buchter, H. P. Jenssen, A. Cassanho, and P. Nicholson, "All Solid State Red, Green, and Blue Pr:YLF Laser," in Advanced Solid State Lasers, W. Bosenberg and M. Fejer, eds., Vol. 19 of OSA Trends in Optics and Photonics Series (Optica Publishing Group, 1998), paper VL1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Exercise Increases Systemic Nitric Oxide Production in Men (1994)

An acute submaximal exercise test increases the formation of nitric oxide, reflected in the increase in urinary excretion of nitrate and cyclic GMP. This increase may contribute to vasodilatation during physical exercise and at least partly explain the beneficial effects of physical training in patients with vascular diseases.
Six Centuries of Russo-Polish Relations (1949)

Six Centuries of Russo-Polish Relations Get access Six Centuries of Russo-Polish Relations. By W. P.and Zelda K. Coates. London, Lawrence & Wishart, 1948. vii + 235 pp. Index. Maps. 812′​′×512′​′⁠. 21s. Y. Y. Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 25, Issue 2, April 1949, Page 233, https://doi.org/10.2307/3017469 Published: 01 April 1949
Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. (1998)

We assessed Ki-ras mutations by single-strand conformation polymorphism followed by DNA sequencing, p53 expression by immunohistochemistry, ploidy status, and S-phase fraction in 66 stage II and 163 stage III colon cancer patients enrolled on a randomized trial of surgery followed by observation or adjuvant levamisole or 5-fluorouracil (5FU) plus levamisole (Intergroup Trial 0035) to see whether these factors were independently associated with survival or with differential effects of adjuvant therapy. A Cox proportional hazards survival model was used to describe marker effects and therapy by marker interactions, with adjustment for the clinical covariates affecting survival. A Bonferroni adjustment was used to account for multiple testing. Mutation of the Ki-ras gene was found in 41% of the cancers and was associated with a poor prognosis in stage II but not stage III. In stage II, 7-year survival was 86% versus 58% in those with wild type versus Ki-ras mutations. After adjustment for treatment and clinical variables, the hazard ratio (HR) for death was 4.5; 95% confidence interval (CI), 1.7-12.1 (P = 0.012). p53 overexpression was found in 63% of cancers and was associated with a favorable survival in stage III but not stage II. Seven-year survival in stage III was 56% with p53 overexpression versus 43% with no p53 expression (HR, 2.2; 95% CI, 1.3-3.6; P = 0.012). Aneuploidy was more common in stage III than in stage II (66 versus 47%; P = 0.009) but was not independently related to survival in either group. The proliferative rate was greater in aneuploid than in diploid cancers but was not related to survival. There was no benefit of adjuvant therapy in stage II nor in any of the stage II subgroups defined by mutational status. In stage III, adjuvant therapy with 5FU plus levamisole improved 7-year survival in patients with wild-type Ki-ras (76 versus 44%; HR, 0.4; 95% CI, 0.2-0.8) and in those without p53 overexpression (64 versus 26%; HR, 0.3; 95% CI, 0.1-0.7). Adjuvant therapy did not benefit those with Ki-ras mutations or p53 overexpression. The effects of adjuvant therapy did not differ according to ploidy status or proliferative rate. Ki-ras mutation is a significant risk factor for death in stage II, and the absence of p53 expression is a significant risk factor for death in stage III colon cancer after adjustment for treatment and clinical covariates. Exploratory analyses suggest that patients with stage III colon cancer with wild-type Ki-ras or no p53 expression benefit from adjuvant 5FU plus levamisole, whereas those with Ki-ras mutations or p53 overexpression do not. An independent study will be required to determine whether response to adjuvant therapy in colon cancer depends on mutational status.
A Novel Myocyte-specific Gene MidoriPromotes the Differentiation of P19CL6 Cells into Cardiomyocytes (2001)

Although several cardiac-specific transcription factors have been shown to play vital roles in various steps during the heart formation, the precise mechanism of the early stage of cardiogenesis has yet to be elucidated. By differential display technique, we tried to identify molecules that are expressed earlier than cardiac transcription factors such as CSX/NKX2-5 and GATA-4 and are involved in cardiomyocyte differentiation using the P19CL6 cell line, which efficiently differentiates into cardiomyocytes when treated with dimethyl sulfoxide. We isolated a novel gene designated Midori. Its deduced amino acid sequence contained an ATP/GTP-binding site, Ig-like domain, and Kringle-like domain. Northern blot analysis revealed that expression of Midori was restricted to the fetal and adult heart and adult skeletal muscle in mice. In whole mount in situ hybridization, Midori was expressed in cardiac crescent and developing heart but not in somites. The MIDORI protein was localized in the nucleus and overexpression of Midori induced expression of endogenous Midori itself, suggesting that MIDORI may act as a transcriptional regulator. Permanent P19CL6 cell lines overexpressing Midori more efficiently differentiated into cardiomyocytes than did parental cells, whereas those overexpressing the antisense Midori less efficiently differentiated. These results suggest that Midori may promote the differentiation of P19CL6 into cardiomyocytes.