gebhart/patrepeval huggingface dataset:
Cutin from agro-waste as a raw material for the production of bioplastics (2017)

Cutin is the main component of plant cuticles constituting the framework that supports the rest of the cuticle components. This biopolymer is composed of esterified bi- and trifunctional fatty acids. Despite its ubiquity in terrestrial plants, it has been underutilized as raw material due to its insolubility and lack of melting point. However, in recent years, a few technologies have been developed to obtain cutin monomers from several agro-wastes at an industrial scale. This review is focused on the description of cutin properties, biodegradability, chemical composition, processability, abundance, and the state of art of the fabrication of cutin-based materials in order to evaluate whether this biopolymer can be considered a source for the production of renewable materials.
Low-loss infrared dielectric material system for broadband dual-range omnidirectional reflectivity (2001)

A material system for broadband thermal IR applications based on branched polyethylene and tellurium is introduced. This system exhibits low absorption losses from 3.5 to 35 microm , has a large index contrast, and is readily deposited as a thin film. These unique features were used to investigate the formation of an omnidirectional reflector that exhibits two distinct, broadband omnidirectional ranges at thermal wavelengths. Reflectivity measurements are presented that confirm the existence of two omnidirectional ranges in the solar atmospheric windows extending from 8 to 12 microm and from 4.5 to 5.5 microm . The measurements are in good agreement with simulations.
A study of electrical characteristics and reliability on flash EEPROM cell (2002)

In this paper, we analyzed the operation of flash EEPROM cell. ATHENA which is process simulator of SILVACO is used to make stacked gate flash memory cell structure, and also analyzed electrical characteristics of write/erase operations as in basic operations. We have studied on the optimum doping concentration of the floating gate to suppress the overerase problem in the Flash EEPROM's. We analyzed gate oxide thickness and gate channel length how to effect in Vth, and then if Tox to be a shorter, Vth will decrease. This phenomenon is important to approve programming speed. As gate channel length is shorter and shorter, Vth decreases severely. Because Vth is effected by DIBL. The leakage current of non-selected cells with source bias 0(V) is high, but if small positive voltage is applied to source bias, the subthreshold current decreases rapidly. And N-type MOSFETs with various doping concentrations were fabricated and their electrical characteristics were analyzed. The results showed that a overerase problem can be prevented if the doping concentration of the floating gate is low enough.
Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease (2018)

Qualitative and quantitative features of this space, and their potential to serve as markers of disease, have been explored by examining continuous-wave fNIRS 3D tomographic time series obtained from the breasts of women who do and do not have breast cancer. Inspection of the coefficient arrays reveals that they are governed predominantly by first-order rate processes, and that each array class exhibits preferred structure that is mainly independent of the others. Discussed are strategies that may serve to extend evaluation of the accessible feature space and how the character of this information holds potential for development of novel clinical and preclinical uses.
Spina bifida aperta induced by valproic acid and by all‐<i>trans</i>‐retinoic acid in the mouse: Distinct differences in morphology and periods of sensitivity (1992)

The antiepileptic drug valproic acid (VPA) has been implicated as a human teratogen causing spina bifida aperta. Recently, we developed a mouse model inducing spina bifida aperta with VPA. To elucidate the pathogenesis of VPA-induced spina bifida aperta we now investigated the anatomy and histology of this defect in the mouse. The morphology of spina bifida aperta induced by all-trans-retinoic acid (RA) was used for comparison. Various doses of VPA and RA were administered at different times to determine the periods of sensitivity for inducing spina bifida aperta with these drugs. Each administration regimen consisted of three doses applied at intervals of 6 hr. RA induced spina bifida aperta during an earlier developmental period (day 8 of gestation) than VPA (day 9 of gestation). The most effective regimens for induction of spina bifida aperta in mice were injections of 3 x 500 mg VPA-Na/kg body weight (b.w.) intraperitoneally on day 9 of gestation at 0, 6, and 12 hr; RA (12.5 mg/kg b.w.) was given orally on day 8 of gestation at 12 and 18 hr, day 9 at 0 hr. VPA did not induce spina bifida aperta on day 8 of gestation and RA did not induce this effect on day 9 of gestation. Histological studies of day 18 fetuses carrying spina bifida aperta were performed. The spina bifida aperta induced by VPA shows a disorganized and necrotic spinal cord. In the vertebral canal were observed cell debris, blood cells, capillaries, macrophages, and rests of meninges. These results indicate that the spinal cord is almost destroyed at the affected section. In contrast, the spina bifida aperta induced by RA demonstrates a spinal cord organized in the gray and white matter, the dorsal and ventral horn. But the neural canal does not exist, only a layer of ependymal cells lies on the surface of the spinal cord. Our results indicate that the morphology of spina bifida aperta induced by VPA differed distinctly from that induced by RA in the mouse fetus. Moreover VPA produced a spina bifida aperta with a specific morphology. Also the period of sensitivity for induction of this lesion differed and occurred earlier for RA than for VPA. VPA and RA may possibly induce spina bifida aperta via different mechanisms in the mouse.
Binding of Thrombin to Human Platelets and its Possible Significance (1976)

Thrombin binds tightly to human platelets. The binding reaction is dependent on the thrombin concentration used. At a physiologically significant thrombin concentration, there are about 500 binding sites per platelet with an apparent dissociation constant of 0.02 u/ml. Autoradiography studies of platelets treated with labelled thrombin showed that the thrombin was located on the platelet surface. Separation of the subcellular fractions of platelets treated with labelled thrombin by density gradient centrifugation revealed that the membrane area contained over 80% of the radioactivity initially applied. Furthermore, isolated platelet membranes dind thrombin similar to intact platelets. These data suggest that the receptors for thrombin are located on the platelet membrane. Cytochalasin A, cytochalasin B or prostoglandin E1 did not have any effect on thrombin binding although these agents inhibited platelet aggregation. Thus, binding of thrombin is not sufficient for aggregation of platelets and other steps are involved. These agents do not affect the induction of stimulation but interfere at a later step in the trhombin-platelet interaction. On the other hand, hirudin completely inhibited binding of thrombin to platelets. It appears that the platelet receptor recognizes that part of the thrombin molecule on its surface which hirudin. Binding studies with serotonin loaded platelets showed a close correlation between thrombin binding and the release reaction.
Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord–stromal tumours (2001)

Calretinin is a sensitive immunohistochemical marker of ovarian sex cord-stromal tumours and may be useful in a diagnostic setting. However, the value is somewhat limited since occasional neoplasms which enter into the morphological differential diagnosis may be positive. Be that as it may, calretinin positivity may be of value in the diagnosis of an ovarian sex cord-stromal tumour and its differentiation from other neoplasms. In this regard, calretinin should always be used as part of a larger panel.
Ambient pressure XPS and IRRAS investigation of ethanol steam reforming on Ni–CeO<sub>2</sub>(111) catalysts: an in situ study of C–C and O–H bond scission (2016)

Ambient-Pressure X-ray Photoelectron Spectroscopy (AP-XPS) and Infrared Reflection Absorption Spectroscopy (AP-IRRAS) have been used to elucidate the active sites and mechanistic steps associated with the ethanol steam reforming reaction (ESR) over Ni-CeO2(111) model catalysts. Our results reveal that surface layers of the ceria substrate are both highly reduced and hydroxylated under reaction conditions while the small supported Ni nanoparticles are present as Ni(0)/NixC. A multifunctional, synergistic role is highlighted in which Ni, CeOx and the interface provide an ensemble effect in the active chemistry that leads to H2. Ni(0) is the active phase leading to both C-C and C-H bond cleavage in ethanol and it is also responsible for carbon accumulation. On the other hand, CeOx is important for the deprotonation of ethanol/water to ethoxy and OH intermediates. The active state of CeOx is a Ce(3+)(OH)x compound that results from extensive reduction by ethanol and the efficient dissociation of water. Additionally, we gain an important insight into the stability and selectivity of the catalyst by its effective water dissociation, where the accumulation of surface carbon can be mitigated by the increased presence of surface OH groups. The co-existence and cooperative interplay of Ni(0) and Ce(3+)(OH)x through a metal-support interaction facilitate oxygen transfer, activation of ethanol/water as well as the removal of coke.
Calibration of lithography simulator by using subresolution patterns (1993)

In this paper, we used actual experimental results to calibrate the 3-D lithography simulator SOLID, a lithography simulator with proven ability to accurately simulate sub-resolution patterns. The RS1 Discover DOE software was used to determine optimum values for the uncertain parameters. The tuned simulator was then used to predict behavior both regular and sub-resolution patterns. The simulation results were compared to actual process data for the final verification.
SEEDS: Superpixels Extracted via Energy-Driven Sampling (2013)

Superpixel algorithms aim to over-segment the image by grouping pixels that belong to the same object. Many state-of-the-art superpixel algorithms rely on minimizing objective functions to enforce color ho- mogeneity. The optimization is accomplished by sophis- ticated methods that progressively build the superpix- els, typically by adding cuts or growing superpixels. As a result, they are computationally too expensive for real-time applications. We introduce a new approach based on a simple hill-climbing optimization. Starting from an initial superpixel partitioning, it continuously refines the superpixels by modifying the boundaries. We define a robust and fast to evaluate energy function, based on enforcing color similarity between the bound- aries and the superpixel color histogram. In a series of experiments, we show that we achieve an excellent com- promise between accuracy and efficiency. We are able to achieve a performance comparable to the state-of- the-art, but in real-time on a single Intel i7 CPU at 2.8GHz.
Biodegradable and bioactive porous scaffold structures prepared using fused deposition modeling (2012)

Three-dimensional printing (3DP) refers to a group of additive manufacturing techniques that can be utilized in tissue engineering applications. Fused deposition modeling (FDM) is a 3DP method capable of using common thermoplastic polymers. However, the scope of materials applicable for FDM has not been fully recognized. The purpose of this study was to examine the creation of biodegradable porous scaffold structures using different materials in FDM and to determine the compressive properties and the fibroblast cell response of the structures. To the best of our knowledge, the printability of a poly(ε-caprolactone)/bioactive glass (PCL/BAG) composite and L-lactide/ε-caprolactone 75/25 mol % copolymer (PLC) was demonstrated for the first time. Scanning electron microscope (SEM) images showed BAG particles at the surface of the printed PCL/BAG scaffolds. Compressive testing showed the possibility of altering the compressive stiffness of a scaffold without changing the compressive modulus. Compressive properties were significantly dependent on porosity level and structural geometry. Fibroblast proliferation was significantly higher in polylactide than in PCL or PCL/BAG composite. Optical microscope images and SEM images showed the viability of the cells, which demonstrated the biocompatibility of the structures.
Improving Database Performance on Simultaneous Multithreading Processors (2005)

Simultaneous multithreading (SMT) allows multiple threads to supply instructions to the instruction pipeline of a superscalar processor. Because threads share processor resources, an SMT system is inherently different from a multiprocessor system and, therefore, utilizing multiple threads on an SMT processor creates new challenges for database implementers. We investigate three thread-based techniques to exploit SMT architectures on memory-resident data. First, we consider running independent operations in separate threads, a technique applied to conventional multiprocessor systems. Second, we describe a novel implementation strategy in which individual operators are implemented in a multi-threaded fashion. Finally, we introduce a new data-structure called a work-ahead set that allows us to use one of the threads to aggressively preload data into the cache for use by the other thread. We evaluate each method with respect to its performance, implementation complexity, and other measures. We also provide guidance regarding when and how to best utilize the various threading techniques. Our experimental results show that by taking advantage of SMT technology we achieve a 30\% to 70\% improvement in throughput over single threaded implementations on in-memory database operations.
Differential Heparin Sensitivity of α-Dystroglycan Binding to Laminins Expressed in Normal and dy/dy Mouse Skeletal Muscle (1998)

The alpha-dystroglycan binding properties of laminins extracted from fully differentiated skeletal muscle were characterized. We observed that the laminins expressed predominantly in normal adult rat or mouse skeletal muscle bound alpha-dystroglycan in a Ca2+-dependent, ionic strength-sensitive, but heparin-insensitive manner as we had observed previously with purified placental merosin (Pall, E. A., Bolton, K. M., and Ervasti, J. M. 1996 J. Biol. Chem. 271, 3817-3821). Rat skeletal muscle laminins partially purified by heparin-agarose affinity chromatography also bound alpha-dystroglycan without sensitivity to heparin. We also confirm previous studies of dystrophic dy/dy mouse skeletal muscle showing that the alpha2 chain of merosin is reduced markedly and that the laminin alpha1 chain is not up-regulated detectably. However, we further observed a quantitative decrease in the expression of laminin beta/gamma chain immunoreactivity in alpha2 chain-deficient dy/dy skeletal muscle and reduced alpha-dystroglycan binding activity in laminin extracts from dy/dy muscle. Most interestingly, the alpha-dystroglycan binding activity of residual laminins expressed in merosin-deficient dy/dy skeletal muscle was inhibited dramatically (69 +/- 19%) by heparin. These results identify a potentially important biochemical difference between the laminins expressed in normal and dy/dy skeletal muscle which may provide a molecular basis for the inability of other laminin variants to compensate fully for the deficiency of merosin in some forms of muscular dystrophy.
Knowledge-Driven Personalized Contextual mHealth Service for Asthma Management in Children (2015)

Wide adoption of smartphones and availability of low-cost sensors has resulted in seamless and continuous monitoring of physiology, environment, and public health notifications. However, personalized digital health and patient empowerment can become a reality only if the complex multisensory and multimodal data is processed within the patient context. Contextual processing of patient data along with personalized medical knowledge can lead to actionable information for better and timely decisions. We present a system called kHealth capable of aggregating multisensory and multimodal data from sensors (passive sensing) and answers to questionnaire (active sensing) from patients with asthma. We present our preliminary data analysis comprising data collected from real patients highlighting the challenges in deploying such an application. The results show strong promise to derive actionable information using a combination of physiological indicators from active and passive sensors that can help doctors determine more precisely the cause, severity, and control level of asthma. Information synthesized from kHealth can be used to alert patients and caregivers for seeking timely clinical assistance to better manage asthma and improve their quality of life.
Online distributed fault detection of sensor measurements (2007)

In wireless sensor networks (WSNs), a faulty sensor may produce incorrect data and transmit them to the other sensors. This would consume the limited energy and bandwidth of WSNs. Furthermore, the base station may make inappropriate decisions when it receives the incorrect data sent by the faulty sensors. To solve these problems, this paper develops an online distributed algorithm to detect such faults by exploring the weighted majority vote scheme. Considering the spatial correlations in WSNs, a faulty sensor can diagnose itself through utilizing the spatial and time information provided by its neighbor sensors. Simulation results show that even when as many as 30% of the sensors are faulty, over 95% of faults can be correctly detected with our algorithm. These results indicate that the proposed algorithm has excellent performance in detecting fault of sensor measurements in WSNs.
Novel role of calcium in exocytosis: mechanism of nematocyst discharge as shown by x-ray microanalysis. (1981)

Mature nematocysts of the sea anemones Rhodactis rhodostoma and Anthopleura elegantissima contain a fluid that has a high concentration of solutes and is extraordinarily rich in calcium (ca. 500-600 mmol/kg wet weight); this contrasts with the surrounding cytoplasm which is rich in potassium but poor in calcium. The undischarged capsule is surrounded by a membrane that probably acts as a selective permeability barrier between the cytoplasm and the nematocyst fluid. During discharge the nematocyst moves to the surface of the nematocyte and comes into contact with the external sea water medium. Calcium, which may be bound to proteins in the undischarged state, is rapidly lost from the fluid; at the same time, sea water enters the capsule. In vitro experiments have already shown that calcium loss increases the osmotic pressure of the capsular fluid, causing an influx of water from the external medium; this influx appears to increase the hydrostatic pressure inside the capsule to the point that the thread everts explosively.
A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects. (1991)

1. The effects of oral administration of 250 mg caffeine or theophylline and placebo on subjective ratings and psychological test performance were studied in a double‐blind crossover experiment in 20 healthy elderly subjects. 2. Performance on the continuous attention task showed a significant improvement compared with placebo with both active treatments. Performance with caffeine was significantly better than with theophylline. Mean error index scores (normalised AUCs) were: placebo‐0.130; caffeine‐0.083; theophylline‐0.093. No other objective measure shows significant treatment effects. 3. Subjective ratings showed that subjects felt significantly more alert on caffeine than on either theophylline or placebo. Subjects also rated themselves as more energetic and interested on caffeine than on placebo. 4. Plasma concentrations of caffeine were lower than those of theophylline (mean 5.76 and 8.72 mg l‐1 respectively at 2 h post‐drug. 5. These results suggest that caffeine is a more potent CNS stimulant than theophylline.
The <i>Xenopus</i> proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties (1997)

The proglucagon gene encodes several hormones that have key roles in the regulation of metabolism. In particular, glucagon-like peptide (GLP-1), a potent stimulus of insulin secretion, is being developed as a therapy for the treatment of non-insulin-dependent diabetes mellitus. To define structural moieties of the molecule that convey its insulinotropic activity, we have cloned and characterized the proglucagon gene from the amphibian, Xenopus laevis. Unexpectedly, these cDNAs were found to encode three unique glucagon-like-1 peptides, termed xenGLP-1A, xenGLP-1B, and xenGLP-1C in addition to the typical proglucagon-derived hormones glucagon and GLP-2. xenGLP-1A, -1B, and -1C were synthesized and tested for their ability to bind and activate the human GLP-1 receptor (hGLP-1R), and to stimulate insulin release from rat pancreas. All three Xenopus GLP-1-like peptides bind effectively to the hGLP-1R and stimulate cAMP production. Surprisingly, xenGLP-1B(1-30) demonstrated higher affinity for the hGLP-1R than hGLP-1 (IC50 of 1.1 +/- 0.4 nM vs. 4.4 +/- 1.0 nM, respectively, P < 0.02) and was equipotent to hGLP-1 in stimulating cAMP production (EC50 of 0.17 +/- 0.02 nM vs. 0.6 +/- 0. 2 nM, respectively, P > 0.05). Further studies demonstrated that hGLP-1, xenGLP-1A, -1B, and -1C stimulate comparable insulin release from the pancreas. These results demonstrate that despite an average of nine amino acid differences between the predicted Xenopus GLPs and hGLP-1, all act as hGLP-1R agonists.
Kinetic determination of stereoselectivity in the anionic polymerization of α‐ethyl‐α‐phenyl‐β‐propiolactone (1983)

Abstract The kinetics of the anionic polymerization of optically active α‐ethyl‐α‐phenyl‐β‐propiolactone (optical purity 16,8%) initiated with bis(triphenylphosphine)iminium acetate was investigated and the rate constants for the homo‐( k ph ) and crosspropagation ( k pc ) (considering R and S enantiomers as comonomers) were determined. The knowledge of the values of k ph and k pc , equal to 1,53·10 −4 and 9,0·10 −5 1· mol −1 ·s −1 , respectively (25°C, CH 2 Cl 2 solvent), allowed us to calculate the distribution of homosequences in the polymer prepared from racemic monomer. The concentration of homosequences was slightly higher than calculated for the process with random enchainment of enantiomers. Thus, the content of homodyads, homotriads, and homotetrads equals 63, 40, and 25%, whereas for the random process it was 50, 25, and 13%, respectively. This difference is, however, too small to create homoblocks which could be responsible for the observed crystallinity of these polymers.
Spontaneous Resolution by Stirred Crystallization (1991)

New insights into the mechanism of crystal nucleation emerge from a study by Kondepudi et al., on the crystallization of NaClO 3 from a stirred solution. Rectangular prisms of the chiral space group P 2 1 3 precipitate from aqueous solutions of the achiral ions. If the solution is not stirred, crystals of both enantiomorphic forms precipitate in equal amounts—exactly as was reported almost one hundred years ago. However, when the NaClO 3 solution is stirred, then almost exclusively only right‐handed or only left‐handed crystals are formed. There is a simple explanation for this extremely surprising and obviously reproducible phenomenon.