gebhart/patrepeval huggingface dataset:
Performance and Glucose Metabolism in Calves Fed a Chromium-Nicotinic Acid Complex or Chromium Chloride (1997)

Twenty-four Holstein bull calves were fed a milk replacer diet to assess the effects of Cr on calf performance and metabolism of glucose. Treatments consisted of no supplemental Cr (control) or 0.4 mg/kg of dry matter of supplemental Cr from CrCl3 or from a Cr-nicotinic acid complex. Supplementation with the Crt-nicotinic acid complex increased the average daily gain and feed efficiency from d 28 to 42, but not over the entire 63-d performance phase. Calves that were fed diets supplemented with CrCl3 or the Cr-nicotinic acid complex had lower plasma glucose concentrations at 45 to 180 min after an i.v. infusion of insulin than did controls. Calves fed diets supplemented with the Cr-nicotinic acid complex also had lower plasma glucose concentrations from 90 to 180 min after insulin challenge than did calves that were fed diets supplemented with CrCl3. After an i.v. infusion of glucose, calves that were fed diets supplemented with CrCl3 had lower serum insulin concentrations at 10 to 25 min after challenge than did controls or calves that were fed diets supplemented with the Cr-nicotinic acid complex. However, the glucose clearance rate after glucose infusion was not affected by Cr supplementation. Chromium supplementation did not markedly affect the performance of calves, but the Cr-nicotinic acid complex and CrCl3 did intensify the response to insulin administered i.v.
A study on latent heat storage exchangers with the high-temperature phase-change material (2001)

This paper presents a theoretical analysis and an experimental test on a shell-and-tube latent heat storage exchanger. The heat exchanger is used to recover high-temperature waste heat from industrial furnaces and off-peak electricity. It can also be integrated into a renewable energy system as an energy storage component. A mathematical model describing the unsteady freezing problem coupled with forced convection is solved numerically to predict the performance of the heat exchanger. It provides the basis for an optimum design of the heat exchanger. The experimental study on the heat exchanger is carried out under various operating conditions. Effects of various parameters, such as the inlet temperature, the mass flow rate, the thickness of the phase-change material and the length of the pipes, on the heat transfer performance of the unit are discussed combined with theoretical prediction. The criterion for analyzing and evaluating the performance of heat exchanger is also proposed. Copyright © 2001 John Wiley & Sons, Ltd.
ChemInform Abstract: PLANT ANTITUMOR AGENTS. 18. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CAMPTOTHECIN N ANALOGS (1980)

Abstract Das Pyridon (I) und Acrylsäuremethylester (II) cyclisieren zum Enbl (III), das sauer in das instabile Keton (IV) umgewandelt wird.
Reliability Analysis for Complex, Repairable Systems (1975)

The reliability of a complex system that is repaired (but not replaced) upon failure will often depend on the system chronological age. If only minimal repair is made so that the intensity (instantaneous rate) of system failure is not disturbed, than a nonhomogeneous Poisson process may be used to model this age-dependent reliability. This paper considers the theoretical and practical implications of the nonhomogeneous Poisson process model for reliability, and gives estimation, hypotheses testing, comparison and goodness of fit procedures when the process has a Weilbull intensity function. Applications of the Weilbull model in the field of reliability and in other areas are discussed. (Author)
Prospective Comparison of Mammography, Sonography, and MRI in Patients Undergoing Neoadjuvant Chemotherapy for Palpable Breast Cancer (2005)

MRI appears to provide the best correlation with pathology-better than physical examination, mammography, and sonography-in patients undergoing neoadjuvant chemotherapy. However, MRI may overestimate (6%) or underestimate (23%) residual disease in approximately 29% of the patients (95% confidence interval, 14-48%).
A New Class of Cyclometalated Ruthenium Sensitizers of the Type ĈNN for Efficient Dye-Sensitized Solar Cells (2011)

A new class of cyclometalated ruthenium sensitizers incorporating a ĈNN ligand and conjugated 2,2'-bipyridine in the ancillary ligand have been designed and synthesized. The photovoltaic performance of JK-206 using an electrolyte containing 0.6 M 1,2-dimethyl-3-propylimidazolium iodide, 0.05 M I(2), 0.1 M LiI, and 0.5 M tert-butylpyridine in CH(3)CN gave a short-circuit photocurrent density of 19.63 mA cm(-2), an open-circuit voltage of 0.74 V, and a fill factor of 0.72, affording an overall conversion efficiency of 10.39%. The efficiency is the highest one reported for dye-sensitized solar cells based on the cyclometalated ruthenium sensitizer of the type ĈNN. Moreover, the same device using a polymer gel electrolyte exhibited a remarkable stability under 1000 h of light soaking at 60 °C, retaining 91% of the initial efficiency of 7.14%.
A Large Area (300 cm2) Gas Scintillation Proportional Counter for X-Ray Astronomy (1978)

A large area gas scintillation proportional counter (GSPC) developed for use as a spectrometer in X-ray astronomy is presented. A crude laboratory version of the xenon cell coupled to a 9 cm diameter ruggedised photomultiplier, has an energy resolution of ~ 11% FWHM at 6 keV over a total geometric area of ~ 300 cm2. The instrument has a high rejection ability for charged particles present in a space environment. A rejection efficiency for Co60 induced events of ~ 90% was achieved, over the energy range 1-20 keV, for an X-ray acceptance of ~ 80%. These results show that the GSPC is a credible improved alternative instrument to a proportional counter with which to study cosmic X-ray sources.
HIGH DENSITY LIPOPROTEIN (HDL) POLYMORPHISMS IN RABBIT II. A STUDY OF THE INHERITED HI 1 AND R 67 ANTIGENS IN RELATION TO HDL POLYPEPTIDES (1976)

SUMMARY Rabbit high density lipoprotein (HDL) has been isolated by ultracentrifugation, delipidated by ether and ethanol, and treated with urea prior to separation of the different polypeptides by gel nitration. The two different genetic polymorphisms known in rabbit HDL were found to reside in two different polypeptides. This conclusion was reached in experiments where a quantitative radial immunodiffusion technique was employed. The results of polyacrylamide gel electrophoresis in SDS indicate that the H1 1 antigen resides in a polypeptide chain with a molecular weight of 40,000, whereas the R 67 antigen resides in a chain with a molecular weight of 17,000.
Amino acid sequence of the active site of Acanthamoeba myosin II. (1986)

We have used the substrate [5,6-3H]UTP for direct photoaffinity labeling of the active site of the heavy chain of myosin II from Acanthamoeba castellanii. The only labeled peptide in a total tryptic digest had the sequence of Thr-Glu-Asn-Thr-Me2Lys-Lys (where Me2Lys represents dimethyllysine) with the substrate covalently bound to the Glu residue. This sequence differs at only one position from the sequence of residues 184-189 of nematode myosin heavy chain (Me2Lys----Lys), a post-translational modification, and at two additional positions from residues 185-190 of rabbit skeletal muscle myosin (Glu----Val and Lys----Arg). The partial sequence of a larger labeled peptide derived from total chymotryptic digestion was compatible with and extended this sequence. A 20-residue sequence that contains the active site, tryptic hexapeptide is otherwise identical in Acanthamoeba and rabbit skeletal muscle myosins and has only one more difference in nematode myosin. Because UTP is a substrate for myosin II and a "zero-length" probe, we believe that it identifies amino acid residues that are very close to the substrate during the catalytic cycle.
Systematic Review of Studies Comparing the Anti-Caries Efficacy of Children’s Toothpaste Containing 600 ppm of Fluoride or Less with High Fluoride Toothpastes of 1,000 ppm or Above (2003)

250 ppm fluoride dentifrice was not as effective in caries prevention in permanent dentition as dentifrice containing 1,000 ppm F or more. More studies have to be carried out to test the anticaries efficacy of 500 against 1,000 ppm and above.
Perception of depth information by means of a wire-actuated haptic interface (2002)

The VIDET project is aimed at investigating the possibility of developing a wearable robotic system for helping the mobility of visually impaired persons. The basic idea involves the conversion of real-time depth data gathered through stereo-vision into a virtual, "bas-relief" model perceivable by means of a haptic interface. In this paper we describe the real-time stereo system, review the basic principles of the two main haptic devices developed so far, and present new experimental results concerning extraction of depth data by the stereo system and haptic perception of the virtual model recovered from stereo-data.
Automatic delineation of malignancy in histopathological head and neck slides (2007)

Recent advances in imaging technology enable us to investigate cancer tissue at cellular level. In this study we focus on wholly-scanned histopathological slides of head and neck tissues. In the context of computer-aided diagnosis, delineation of malignant regions is achieved using a powerful classification algorithm, which heavily depends on the features extracted by aid of a newly proposed cell nuclei clustering technique. The preliminary experimental results demonstrate a high accuracy of the proposed method.
Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694 (2015)

Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-cells and natural killer (NK) cells. Thus, ITK and RLK inhibitors have therapeutic potential in a number of human autoimmune, inflammatory, and malignant diseases. Here we describe a novel ITK/RLK inhibitor, PRN694, which covalently binds to cysteine residues 442 of ITK and 350 of RLK and blocks kinase activity. Molecular modeling was utilized to design molecules that interact with cysteine while binding to the ATP binding site in the kinase domain. PRN694 exhibits extended target residence time on ITK and RLK and is highly selective for a subset of the TEC kinase family. In vitro cellular assays confirm that PRN694 prevents T-cell receptor- and Fc receptor-induced cellular and molecular activation, inhibits T-cell receptor-induced T-cell proliferation, and blocks proinflammatory cytokine release as well as activation of Th17 cells. Ex vivo assays demonstrate inhibitory activity against T-cell prolymphocytic leukemia cells, and in vivo assays demonstrate durable pharmacodynamic effects on ITK, which reduces an oxazolone-induced delayed type hypersensitivity reaction. These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo. The results from this study highlight potential applications of this dual inhibitor for the treatment of T-cell- or NK cell-mediated inflammatory, autoimmune, and malignant diseases.
The Source-Scanning Algorithm: mapping the distribution of seismic sources in time and space (2004)

We introduce a new method, which we call the Source-Scanning Algorithm (SSA), for imaging the distribution of seismic sources in both time and space. Using trial locations and origin times, the method calculates the ‘brightness’ function by summing the absolute amplitudes observed at all stations at their respective predicted arrival times. The spatial and temporal distribution of sources is then identified by a systematic search throughout the model space and time for the maximum brightness. The greatest advantages of this method are that: (1) it exploits waveform information (both arrival times and relative amplitudes) without the need to calculate high-frequency synthetic seismograms; and (2) it requires neither pre-assembled phase-picking data nor any a priori assumptions about the source geometry. A series of tests using synthetic data have shown that this method is robust and can faithfully recover the input source configuration to within 1 grid interval. Finally, we demonstrate the value of the algorithm by locating a typical tremor event with emergent waveforms that occurred during the recent episodic tremor and slip (ETS) sequence in the northern Cascadia subduction zone.
The synthesis of a network to have a sine-squared impulse response (1952)

The method of moments, as used in statistics, is applied to the problem of synthesizing a network to have a prescribed impulse response; in particular, to have a sine-squared response. One of the advantages of the method is that the basic delay associated with the output of the network does not have to be specified beforehand but is allowed to vary so as to get the best approximation to the desired waveform from a network of given complexity.A numerical example leads to a design for a network consisting of three inductors and six capacitors in a ladder structure working between resistive terminations. The departure of the impulse response from the sine-squared curve does not exceed 2% of the peak amplitude of the pulse. The approximation could be improved by the use of more components.
Analysis of <sup>13</sup>C and <sup>15</sup>N CPMAS NMR‐spectra of soil organic matter and composts (1991)

15N and 13C CPMAS spectra of composted plants are presented. The plants (L. rigidium and Zea mays) were grown in 15N enriched medium and fermented for several months until an approx. 80% of the dry matter was lost. In all 15N spectra the secondary amide/peptide peaks at 87 ppm contributes more than 80% of the total intensity. No new 15N peaks are formed during the fermentation process. Older attempts to assign a significant fraction of humic acid nitrogen to heteroaromatic structures formed in the fermentation process are thus most probably wrong.
RACK1 Promotes Non-small-cell Lung Cancer Tumorigenicity through Activating Sonic Hedgehog Signaling Pathway (2012)

Non-small-cell lung cancer (NSCLC) is a deadly disease due to lack of effective diagnosis biomarker and therapeutic target. Much effort has been made in defining gene defects in NSCLC, but its full molecular pathogenesis remains unexplored. Here, we found RACK1 (receptor of activated kinase 1) was elevated in most NSCLC, and its expression level correlated with key pathological characteristics including tumor differentiation, stage, and metastasis. In addition, RACK1 activated sonic hedgehog signaling pathway by interacting with and activating Smoothened to mediate Gli1-dependent transcription in NSCLC cells. And silencing RACK1 dramatically inhibited in vivo tumor growth and metastasis by blocking the sonic hedgehog signaling pathway. These results suggest that RACK1 represents a new promising diagnosis biomarker and therapeutic target for NSCLC.
Nicotinic receptor abnormalities in the cerebellar cortex in autism (2002)

Autism is a common developmental disorder associated with structural and inferred neurochemical abnormalities of the brain. Cerebellar abnormalities frequently have been identified, based on neuroimaging or neuropathology. Recently, the cholinergic neurotransmitter system has been implicated on the basis of nicotinic receptor loss in the cerebral cortex. Cerebellar cholinergic activities were therefore investigated in autopsy tissue from a series of autistic individuals. The presynaptic cholinergic enzyme, choline acetyltransferase, together with nicotinic and muscarinic receptor subtypes were compared in the cerebellum from age-matched mentally retarded autistic (eight), normal control (10) and non-autistic mentally retarded individuals (11). The nicotinic receptor binding the agonist epibatidine (the high affinity receptor subtype, consisting primarily of alpha3 and alpha4, together with beta2 receptor subunits) was significantly reduced by 40-50% in the granule cell, Purkinje and molecular layers in the autistic compared with the normal group (P < 0.05). There was an opposite increase (3-fold) in the nicotinic receptor binding alpha-bungarotoxin (to the alpha7 subunit) which reached significance in the granule cell layer (P < 0.05). These receptor changes were paralleled by a significant reduction (P < 0.05) and non-significant increase, respectively, of alpha4 and alpha7 receptor subunit immunoreactivity measured using western blotting. Immunohistochemically loss of alpha(4 )reactivity was apparent from Purkinje and the other cell layers, with increased alpha7 reactivity in the granule cell layer. There were no significant changes in choline acetyltransferase activity, or in muscarinic M1 and M2 receptor subtypes in autism. In the non-autistic mentally retarded group, the only significant abnormality was a reduction in epibatidine binding in the granule cell and Purkinje layers. In two autistic cases examined histologically, Purkinje cell loss was observed in multiple lobules throughout the vermis and hemispheres. This was more severe in one case with epilepsy, which also showed vermis folial malformation. The case with less severe Purkinje cell loss also showed cerebellar white matter thinning and demyelination. These findings indicate a loss of the cerebellar nicotinic alpha4 receptor subunit in autism which may relate to the loss of Purkinje cells, and a compensatory increase in the alpha7 subunit. It remains to be determined how these receptor abnormalities are involved in neurodevelopment in autism and what is the relationship to mental function. Since nicotinic receptor agonists enhance attentional function and also induce an elevation in the high affinity receptor, nicotinic therapy in autism may be worth considering.
Synthesis of yellow and red fluorescent 1,3a,6a-triazapentalenes and the theoretical investigation of their optical properties (2014)

To expand the originally developed fluorescent 1,3a,6a-triazapentalenes as fluorescent labelling reagents, the fluorescence wavelength of the 1,3a,6a-triazapentalenes was extended to the red color region. Based on the noteworthy correlation of the fluorescence wavelength with the inductive effect of the 2-substituent, electron-deficient 2-(2-cyano-4-methoxycarbonylphenyl)-1,3a,6a-triazapentalene and 2-(2,6-dicyano-4-methoxycarbonylphenyl)-1,3a,6a-triazapentalene were synthesized. The former exhibited yellow fluorescence and the latter exhibited red fluorescence, and both compounds exhibited large Stokes shifts, and the 1,3a,6a-triazapentalene system enabled the same fluorescent chromophore to cover the entire region of visible wavelengths. The potential applications of the 1,3a,6a-triazapentalenes as fluorescent probes in the fields of the life sciences were investigated, and the 1,3a,6a-triazapentalene system was clearly proven to be useful as a fluorescent reagent for live cell imaging. Quantum chemical calculations were performed to investigate the optical properties of the 1,3a,6a-triazapentalenes. These calculations revealed that the excitation involves a significant charge-transfer from the 1,3a,6a-triazapentalene skeleton to the 2-substituent. The calculated absorption and fluorescence wavelengths showed a good correlation with the experimental ones, and thus the system could enable the theoretical design of substituents with the desired optical properties.
Facile Fabrication of Light, Flexible and Multifunctional Graphene Fibers (2012)

Macroscopic graphene fibers with strength comparable to carbon nanotube yarns have been fabricated with a facile dimensionally-confined hydrothermal strategy from low-cost, aqueous graphite oxide suspensions, which is shapable, weavable, and has a density of less than 1/7 conventional carbon fibers. In combination with the easy in situ and post-synthesis functionalization, the highly flexible graphene fibers can be woven into smart textiles.
[Relationship between arterial blood gas tensions and a clinical scoring system in asthmatic patients]. (1992)

We evaluated the relationship between blood gas tensions and a clinical scoring system in pediatric asthma patients, who were divided into two groups according to their ages (under 5 years and over 6 years). The clinical score was derived from Mitsui, which was constructed using reference only to clinical symptoms and signs. The clinical scores had a statistically significant correlation with PaO2, PaCO2, SaO2 and pH in both groups. However there were fluctuations between clinical score and blood gas tensions. A low clinical score did not exclude hypoxemia. There were no statistical differences between the two groups, but subjects under 5 years old showed better correlation. This scoring system is useful to evaluate the degree of asthma attack, especially severe attack, both in younger (under 5 years) and older (over 6 years) asthmatic patients.
Ultrasound Increases the Rate of Bacterial Cell Growth (2003)

Ultrasound was employed to increase the growth rate of bacterial cells attached to surfaces. Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli cells adhered to and grew on a polyethylene surface in the presence of ultrasound. It was found that low-frequency ultrasound (70 kHz) of low acoustic intensity (<2 W/cm(2)) increased the growth rate of the cells compared to growth without ultrasound. However, at high intensity levels, cells were partially removed from the surface. Ultrasound also enhanced planktonic growth of S. epidermidis and other planktonic bacteria. It is hypothesized that ultrasound increases the rate of transport of oxygen and nutrients to the cells and increases the rate of transport of waste products away from the cells, thus enhancing their growth.
Clinical trials with bis-dioxopiperazine propane (ICRF 159; NSC 129, 943) in acute leukaemias. (1975)

Clinical experience is reported with bis-dioxopiperazine propane (ICRF 159) in 20 children with acute leukaemia in relapse. They were resistant to most of the generally used cytotoxic drugs. Despite the unfavourable selection of cases, two complete and seven incomplete remissions lasting from 1 to 6 months were obtained.
A framework of survivability model for wireless sensor network (2006)

Wireless sensor network (WSN) should be capable of fulfilling its mission, in a timely manner, in the middle of intrusion, attacks, accidents and failures in hostile environment. However, current security mechanisms for WSN are able to satisfy confidentiality, integrity, and authentication properties using cipher algorithms, key management schemes, and so on, but they are not enough to meet above requirements. Therefore, we propose a framework of survivability model for WSN. Our model adopts software rejuvenation methodology, which is applicable in security field and also less expensive. We model and analyze each cluster of a hierarchical cluster based WSN as a stochastic process based on semi-Markov process (SMP) and discrete-time Markov chain (DTMC). The model analysis indicates the feasibility of our approach.