gebhart/patrepeval huggingface dataset:
Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin. (1987)

1. Intracellular-Ca2+-force relationships were investigated in porcine epicardial coronary arteries by the simultaneous measurement of aequorin luminescence and isometric force. 2. In response to K+ depolarization and histamine, force and aequorin light rose monophasically. In response to carbachol and serotonin, tonic contractions were accompanied by biphasic aequorin signals consisting of an initial spike followed by a low plateau. Contractions produced by prostaglandin F2 alpha (PGF2 alpha) or the endoperoxide analogue U-46619 were accompanied by little or no detectable rise in light. 3. Comparison of steady-state force to steady-state light levels indicated that agonists gave greater force for a given intracellular Ca2+ concentration ([Ca2+]i) compared to that seen during K+ contractures. 4. In Ca2+-free bathing media, carbachol produced a transient contraction accompanied by a transient intracellular Ca2+ spike indicating release of Ca2+ from intracellular storage sites. 5. In Ca2+-free bathing media PGF2 alpha produced a tonic contraction with no detectable change in light. 6. These results suggest that changes in the sensitivity of the contractile apparatus to Ca2+ or other activator systems may be as important a mechanism of contraction as are changes in [Ca2+]i.
Highly parallel mode decision method for HEVC (2013)

High Efficiency Video Coding (HEVC) standard achieves double compression efficiency compared to H.264/AVC with the adoption of more flexible coding structure and advanced coding tools. On the other hand, the coding mode space is too large and it's very time consuming for an HEVC encoder to search for the best coding mode. With the development of multi-core or many-core computing architecture, parallelizing HEVC encoding on such platforms is an efficient approach to fulfill the high computational requirement. In this paper, we exploit the potential parallelism in HEVC mode decision (MD) process and propose a highly parallel MD method which works in a motion estimation region (MER). Specifically, we analyze and remove data dependencies that hinder parallel MD, including motion estimation (ME) dependencies and entropy coding dependencies, and then the MD computation for different blocks within the same MER can be computed concurrently. Experimental results show that our proposed parallel MD method gets an overall speed up of more than 14x with negligible quality loss (1.79% bit rate increasing), compared with the non-parallel baseline.
Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI (2011)

The results demonstrate that combining ERT with anti-TNF-alpha therapy improved the treatment outcome and led to significant clinical benefit. They also further validate the usefulness of TNF-alpha, RANKL and other inflammatory molecules as biomarkers for the MPS disorders. Further evaluation of this combination approach in other MPS animal models and patients is warranted.
Monitoring Satellite Channel Performance - An Automatic System Based on the HP 8568A Spectrum Analyzer (1983)

Summary form only given. A small system has been developed to automatically monitor the carriers of a satellite system. Satellite signals are zicnitored at I.F. at an earth station using the' HP Model 8568A programmable spectrum analyzer.
Constructing XML-speaking wrappers for WEB applications: towards an interoperating WEB (2002)

We discuss an architecture for integrating WWW applications that offer information and services in the same domain. At the center of this architecture exists a mediator, whose responsibilities are to interact with the user and to effectively exchange information with the underlying applications in order to accomplish the user's task. The integration and interoperation of the existing applications are based on the availability of a common domain model, explicitly represented in XML. More specifically we have developed a general method for constructing wrappers for Web-based applications, so that they exchange data with shared semantics such as defined in the XML domain model. At run-time, the user's requests result in the mediator's XML queries to the application wrappers, which, in turn, invoke appropriate methods on the wrapped applications and extract XML data from their responses to these queries.
Immunological mechanisms of sublingual allergen-specific immunotherapy (2011)

Within the last 100 years of allergen-specific immunotherapy, many clinical and scientific efforts have been made to establish alternative noninvasive allergen application strategies. Thus, intra-oral allergen delivery to the sublingual mucosa has been proven to be safe and effective. As a consequence, to date, sublingual immunotherapy (SLIT) is widely accepted by most allergists as an alternative to conventional subcutaneous immunotherapy. Although immunological mechanisms remain to be elucidated in detail, several studies in mice and humans within recent years provided deeper insights into local as well as systemic immunological features in response to SLIT. First of all, it was shown that the target organ, the oral mucosa, harbours a sophisticated immunological network as an important prerequisite for SLIT, which contains among other cells, local antigen-presenting cells (APC), such as dendritic cells (DCs), with a constitutive disposition to enforce tolerogenic mechanisms. Further on, basic research on local DCs within the oral mucosa gave rise to possible alternative strategies to deliver the allergens to other mucosal regions than sublingual tissue, such as the vestibulum oris. Moreover, characterization of oral DCs led to the identification of target structures for both allergens as well as adjuvants, which could be applied during SLIT. Altogether, SLIT came a long way since its very beginning in the last century and some, but not all questions about SLIT could be answered so far. However, recent research efforts as well as clinical approaches paved the way for another exciting 100 years of SLIT.
Ruxolitinib‐induced reversal of alopecia universalis in a patient with essential thrombocythemia (2014)

Ruxolitinib is an inhibitor of activated JAK1 and JAK2 approved for the treatment of patients with myelofibrosis 1. Disregulated activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, caused by activating mutations of JAK2, myeloproliferative leukemia virus oncogene, the thrombopoietin receptor (MPL), and calreticulin (CALR), is implicated in the uncontrolled proliferation of hematopoietic progenitors and the generation of a proinflammatory reaction responsible for symptomatic burden 2. Ruxolitinib is under scrutiny in other hematologic and solid malignances as well as in rheumatoid arthritis and psoriasis. Recent data suggest that the list of autoimmune disorders in which ruxolitinib may be efficacious should include alopecia areata (AA) 3. It is assumed that the cytolytic damage to the hair follicle in AA is caused by autoreactive CD8+ T cells that expand and self-maintain through a cascade of cytokines including interferon gamma, interleukin-2 and -15; these cytokine's receptors signal through JAK1 and JAK2 (JAK1/JAK3 for interferon), therefore, they are inhibited by ruxolitinib 4. Topical administration of ruxolitinib promoted a full coat of hair in a mouse model of AA, and three individuals with AA receiving 20 mg ruxolitinib twice daily exhibited near-complete hair regrowth within 3–5 months 3. A 24-year old lady was diagnosed with essential thrombocythemia in 1992 because of sustained thrombocytosis (650 × 109/L) and consistent bone marrow biopsy. She remained untreated until 2006, when platelet count was 1,200 × 109/L and she complained of severe microvascular symptoms; at that time, she was found JAK2V617F mutated. We prescribed interferon-alpha, that was withdrawn soon for intolerance. She refused hydroxyurea and anagrelide on several occasions, notwithstanding severe complains. Finally, in 2009, she was enrolled in a phase II trial (NCT00726232) with ruxolitinib 5; she is still on therapy at 15 mg twice daily after 71 months with control of platelet count, complete resolution of symptoms, and no side effects. On March 2002, the patient had been diagnosed as suffering from AA, eventuating into alopecia universalis in 2006 with loss of eyelashes and eyebrows (Image 1A). Then, after 10 months of receiving ruxolitinib, she presented an undeniable improvement of alopecia with progressively extending areas of hair regrowth shortly leading to almost complete recovery, that is, durable at 50+ months (Image 1B). At the time of hair regrowth in the patient, we suspected an association with ruxolitinib administration, but could not substantiate it. After the seminal report of Xing et al., it is now clear that the remission of alopecia universalis was a highly desirable “side effect” of therapy in our patient receiving ruxolitinib for other reasons.
Analyzing modular CNN architectures for joint depth prediction and semantic segmentation (2017)

This paper addresses the task of designing a modular neural network architecture that jointly solves different tasks. As an example we use the tasks of depth estimation and semantic segmentation given a single RGB image. The main focus of this work is to analyze the cross-modality influence between depth and semantic prediction maps on their joint refinement. While most of the previous works solely focus on measuring improvements in accuracy, we propose a way to quantify the cross-modality influence. We show that there is a relationship between final accuracy and cross-modality influence, although not a simple linear one. Hence a larger cross-modality influence does not necessarily translate into an improved accuracy. We find that a beneficial balance between the cross-modality influences can be achieved by network architecture and conjecture that this relationship can be utilized to understand different network design choices. Towards this end we propose a Convolutional Neural Network (CNN) architecture that fuses the state-of-the-art results for depth estimation and semantic labeling. By balancing the cross-modality influences between depth and semantic prediction, we achieve improved results for both tasks using the NYU-Depth v2 benchmark.
<title>Continuous-wave quantum cascade lasers in the 4- to 10-um wavelength region</title> (1996)

Continuous wave operation of quantum cascade lasers at lambda on the order of magnitude 4.6 micrometer and 8 micrometer is reported above liquid nitrogen temperature with few miliwatts of optical power. For the devices operating at lambda on the order of 4.6 micrometer, the single mode spectrum is temperature tunable over 1.8 cm<SUP>-1</SUP>. A linewidth of 115 Mhz is measured with a Fabry-Perot on free running devices. Gain measurements show evidence for ultra low linewidth enhancement factor alpha less than 0.1. These devices also operated in pulse mode with 20 mW peak power at 200 K.
Situational Context for Ranking in Personal Search (2017)

Modern search engines leverage a variety of sources, beyond the conventional query-document content similarity, to improve their ranking performance. Among them, query context has attracted attention in prior work. Previously, query context was mainly modeled by user search history, either long-term or short-term, to help the ranking of future queries. In this paper, we focus on situational context, i.e., the contextual features of the current search request that are independent from both query content and user history. As an example, situational context can depend on search request time and location. We propose two context-aware ranking models based on neural networks. The first model learns a low-dimensional deep representation from the combination of contextual features. The second model extends the first one by leveraging binarized contextual features in addition to the high-level abstractions learned using a deep network.
Properties of Spherical Alumina Particles Obtained by Oxy-propane Gas Flame Spraying (1982)

プロパン酸素炎にて得られたアルミナ球状粒子を走査型電子顕微鏡並びにX線回折によって検討した.アルミナ粒子の球状率は炎中の粉末濃度, 粉末輸送ガスの種類並びに粉末の活性度に影響される.球状粒子の表面形態は繊維状の微晶と粒状の粗晶に大別される.また, 結晶相はα-及びδ-Al2O3で構成され, 粒径が小さくなるほどδ-Al2O3の量が増大する. このδ-Al2O3は, 1300℃×3h加熱することにより完全にα-Al2O3となる.
Global Laboratory Experience of CO2-EOR Flooding (2009)

Primary and secondary drive oil production mechanisms are coming short in meeting the ever increasing global oil demand. Currently, many tertiary recovery-EOR projects are in the design or implementation stage in many parts of the world to help meeting this extra global oil demand. Good number of these projects involves certain kinds of CO2 gas injection. To help match the technical results of these projects and their economic viability under the current oil prices, the industry should learn from the lessons of the available global field, pilot and laboratory technical evaluation experiences. This is to avoid unnecessary losses in time and money and to make the best incremental oil recovery possible. To master the performance of CO2 flooding and provide accurate data for designing an oil development plan, a comprehensive investigation of CO2 flooding phase behavior and mechanisms based on laboratory study needs to be conducted. This is a challending prospect technically and economically. The results of a large number of CO2 gas injection laboratory technical evaluations have been reported in the literature. This paper tries to give a serious and comprehensive review of the past global experience of laboratory CO2-EOR flooding, and reports the best practices of laboratory technical evaluations and to highlight the uncertainties and limitations of these evaluations. A large number of technical papers were reviewed to describe the laboratory experiments that are most performed for CO2 flooding evaluation. The main issues that could be addressed using laboratory technical evaluation are covered including PVT properties of different CO2-Oil mixtures, effect of Rock Pore Structure on CO2 Miscible Displacment, effect of WAG and Wettability on CO2-EOR Flooding, assessement of Asphaltene Deposition, and effect of Slug Size on Oil Recovery by CO2 Miscible Flooding and finally CO2 flooding in naturally fractured reservoirs. Finally, the paper reports on the proper utilization of any attainable laboratory data and its limitations.
Group Handover Scheme Using Adjusted Delay for Multi-Access Networks (2010)

In this paper, we propose a group handover scheme in multi-access networks, which utilizes adjusted delay to prevent handover blockings caused by a group handover. In the group handover, a lot of users try to initiate a handover at the same time, which causes network congestion and increases the probability that the handover would be blocked. In our proposed scheme, to prevent these problems of a group handover, each user which participates in the group handover, optimally selects an access point(AP) based on the remaining resources of the AP, and each user initiates a handover after adjusted delay to prevent network congestion. To find an optimal AP selection strategy, we formulate an optimization problem whose objective is to minimize handover blocking probability, and derive an optimal solution by using the Karush-Kuhn-Tucker (KKT) condition. Through performance analysis and simulation results, we show that our proposed scheme can reduce handover blocking probability in a group handover compared to a conventional scheme and keep handover blocking probability to be less than the maximum allowable value of handover blocking probability.
Microglial Activation in Traumatic Brain Injury (2017)

Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and mediating the immune response against peripheral infection. Microglia rapidly become activated in response to CNS damage. Depending on the nature of the stimulus, microglia can take a number of activation states, which correspond to altered microglia morphology, gene expression and function. It has been reported that early microglia activation following traumatic brain injury (TBI) may contribute to the restoration of homeostasis in the brain. On the other hand, if they remain chronically activated, such cells display a classically activated phenotype, releasing pro-inflammatory molecules, resulting in further tissue damage and contributing potentially to neurodegeneration. However, new evidence suggests that this classification is over-simplistic and the balance of activation states can vary at different points. In this article, we review the role of microglia in TBI, analyzing their distribution, morphology and functional phenotype over time in animal models and in humans. Animal studies have allowed genetic and pharmacological manipulations of microglia activation, in order to define their role. In addition, we describe investigations on the <i>in vivo</i> imaging of microglia using translocator protein (TSPO) PET and autoradiography, showing that microglial activation can occur in regions far remote from sites of focal injuries, in humans and animal models of TBI. Finally, we outline some novel potential therapeutic approaches that prime microglia/macrophages toward the beneficial restorative microglial phenotype after TBI.
Novel directional ion energy analyzer (1982)

A new ion energy analyzer with high angular resolution (⩽3×10−4 sr) is described. It consists of a microchannel plate followed by a retarding-grid type analyzer. The microchannel plate is not used for charge multiplication but as a geometric filter with narrow angular passband (ϑ≃0.6°) yet high transparency (T≃60%). The energy analyzer is used to measure the true velocity space distribution of low-energy ion beams (Eb = 10–100 eV) in a double plasma device. Its superior performance over the conventional gridded energy analyzer is demonstrated. Applications to the study of beam wakes are shown.
Investigations in high-precision sorting. (1979)

We have investigated the accuracy with which droplets containing cells can be sorted individually onto known and thus relocatable positions. The presence and random arrival of cells and particles in the sorter jet disturbs the orderly production and deflection of droplets, causing a dispersion of sorted droplet trajectories. The magnitude of this dispersion is a function of the phase relationship between the arrival of a cell at the end of the jet and the droplet formation. Using a modified Becton Dickinson Fluorescence-Activated Cell Sorter, we selected for sorting only those droplets that formed with a cell near the center of the droplet. We used this technique to sort Lewis lung tumor cells. The dispersion of droplet positions was reduced from over 3% to about 1% of an average deflection of typically 15 mm for a nozzle with a 50-micron diameter orifice. Sorting onto a surface such as magnetic tape or a microscope slide introduces another uncertainty in position because the cell may be located anywhere within the wetted radius of the droplet on the slide. Sorting onto less-wettable surfaces reduces the wetted radius and thus the variation in cell position.
[Growth regulation of sex steroid hormone in endometrial carcinoma transplanted into nude mice]. (1991)

By using ovariectomized nude mice, the hormone reactivity of endometrial carcinoma was evaluated. HEC-88nu cultured cells originated from human endometrial carcinoma were first transplanted to the animal in each experiment. Estrogen receptor (ER) of HEC-88nu reveals positive originally. Hormone pellets containing medroxyprogesterone acetate (MPA) and 17 beta-estradiol (E2) were used. The results were as follows: 1. The proliferation of this tumor was accelerated remarkably by administration of E2 pellet. 2. By administration of MPA pellet, the proliferation was inhibited from the beginning but progressed flatly afterwards maintaining 50% of the control. 3. When MPA was administered upon priming the tumor with E2, the proliferation began to be inhibited after 2 weeks developing 60% of suppression 5 weeks later. 4. Progesterone receptor (PR) of the tumor was induced starting at week 2 when E2 was given and revealed 189 fmol/mgP at week 5. 5. As the morphological changes due to hormone, light eosin-stainability, rarefaction and swelling of the cytoplasms were the common characteristics. 6. It was suggested that both hormonal and pharmacological actions take part in the mechanism of progestin to act on endometrial carcinoma.
Activation of cAMP-dependent protein kinase is necessary for actin rearrangements in human neutrophils during phagocytosis (2000)

We have investigated the role of cAMP and cAMP-dependent protein kinase (cAPK) in neutrophil phagocytosis. Inhibition of cAPK with H-89 reduced complement- and IgG-dependent phagocytosis to 83 and 46%, respectively. Fluorescence intensity measurements of phalloidin-stained actin in neutrophils showed a reduced amount of filamentous actin (F-actin) in pseudopods and around the phagosome in cells treated with H-89 or cAMP-elevating agents (forskolin and rolipram). The amount of phosphotyrosine-containing proteins was also reduced in pseudopods and around the phagosome. Taken together, the data show that cAMP/cAPK regulates F-actin reorganization during receptor-mediated phagocytosis, particularly triggered by IgG-FcR interaction. Our results support the hypothesis that active subcortical reorganization of F-actin is a prerequisite for FcR-mediated phagocytosis, but is less important during CR3-mediated ingestion.
Thermal Cure Study of a Low-<i>k</i> Methyl Silsesquioxane for Intermetal Dielectric Application by FT-IR Spectroscopy (2000)

In this paper, Fourier transform infrared (FT-IR) spectroscopy is used to study the thermal properties of methyl silsesquioxane (MSQ), an important low-dielectric-constant organic spin-on glass for semiconductor device fabrication. The compositional and structural changes of MSQ with temperature are investigated in detail. The cross-linking process, where the three-dimensional networked structure is formed, is found to start at room temperature, and is almost complete at the typical baking temperature of 250 °C. Further cross-linking occurs during the curing process at 425 °C, and small short-chain clusters can also be driven away at this temperature by sublimation. In this study, we have assigned all the MSQ IR peaks and we have used the long-chain O–Si–O IR peak to calculate the “degree of cross-linking” quantitatively.