gebhart/patrepeval huggingface dataset:
Optimization of a phased-array transducer for multiple harmonic imaging in medical applications: frequency and topology (2011)

Second-harmonic imaging is currently one of the standards in commercial echographic systems for diagnosis, because of its high spatial resolution and low sensitivity to clutter and near-field artifacts. The use of nonlinear phenomena mirrors is a great set of solutions to improve echographic image resolution. To further enhance the resolution and image quality, the combination of the 3rd to 5th harmonics--dubbed the superharmonics--could be used. However, this requires a bandwidth exceeding that of conventional transducers. A promising solution features a phased-array design with interleaved low- and high-frequency elements for transmission and reception, respectively. Because the amplitude of the backscattered higher harmonics at the transducer surface is relatively low, it is highly desirable to increase the sensitivity in reception. Therefore, we investigated the optimization of the number of elements in the receiving aperture as well as their arrangement (topology). A variety of configurations was considered, including one transmit element for each receive element (1/2) up to one transmit for 7 receive elements (1/8). The topologies are assessed based on the ratio of the harmonic peak pressures in the main and grating lobes. Further, the higher harmonic level is maximized by optimization of the center frequency of the transmitted pulse. The achievable SNR for a specific application is a compromise between the frequency-dependent attenuation and nonlinearity at a required penetration depth. To calculate the SNR of the complete imaging chain, we use an approach analogous to the sonar equation used in underwater acoustics. The generated harmonic pressure fields caused by nonlinear wave propagation were modeled with the iterative nonlinear contrast source (INCS) method, the KZK, or the Burger's equation. The optimal topology for superharmonic imaging was an interleaved design with 1 transmit element per 6 receive elements. It improves the SNR by ~5 dB compared with the interleaved (1/2) design reported in literature. The optimal transmit frequency for superharmonic echocardiography was found to be 1.0 to 1.2 MHz. For superharmonic abdominal imaging this frequency was found to be 1.7 to 1.9 MHz. For 2nd-harmonic echocardiography, the optimal transmit frequency of 1.8 MHz reported in the literature was corroborated with our simulation results.
Leptospirosis and its Public Health Significance: A Review (2012)

Leptospirosis is a worldwide zoonosis of global importance. It occurs in both developing and developed countries and large outbreaks have been reported all over the world. Now leptospirosis is being recognized as emerging infectious disease. The disease is caused by spiral shaped bacteria called Leptospira, which has similar morphology. The disease is endemic to tropical and subtropical area where heavy rainfall and humanity is found. The disease is highly zoonotic through contact with urine from infected animal or though ingestion of contaminated feed and water by Leptospira. The clinical pictures of leptospirosis do not vary greatly with the species of animals. In human; individual working in agriculture and sewage, veterinarians and individuals in close contact with animals are risk groups. Direct examination, serology and molecular techniques are the mostly commonly used in the diagnosis of leptospirosis. Best results have been recorded with specific serum therapy and by administration of antibiotics like tetracycline, chloramphenicol and penicillin. Prevention and control of leptospirosis require elimination of the carrier state, control of rodents and maintenance of environmental condition and immunization of the animal.
Association of Triclosan to Casein Proteins Through Solvent‐Mediated High‐Pressure Homogenization (2009)

The association of triclosan (TCS), a widely used hydrophobic compound, to the bovine casein micelle is investigated in this study. The use of high-pressure homogenization (HPH) at 0, 100, 200, and 300 MPa was introduced as a method for the dissociation of casein micelles in a skim milk/ethanol solution (1: 1, v/v) in the presence of TCS at 20, 80, and 160 mg/L where ethanol evaporation served as the final step for TCS association to caseins. The majority of TCS (over 80%) was associated with the caseins regardless of initial TCS concentration or applied pressure. TCS association to caseins was enhanced by 30% with continued pressurization to 300 MPa. Micellar dissociation and reassociation was found to be an irreversible process as evidenced by microscopy images. Pressurization to 300 MPa resulted in the formation of an integrated protein network of casein proteins and noncovalently linked whey proteins where the solubility of TCS was enhanced up to 40 times its reported water solubility at the highest initial TCS level of 160 mg/L. Reformed micelles exhibited Newtonian flow behavior at all pressure levels. This study provides evidence for the solubility enhancing quality of TCS through the solvent-mediated pressure/shear-induced dissociation of casein proteins.
A p56 -independent Pathway of CD2 Signaling Involves Jun Kinase (1998)

The p56 Src family non-receptor tyrosine kinase has been shown to be critical for T lymphocyte differentiation and activation. Hence in the absence of p56, T cell receptor triggered activation does not occur. We now provide evidence for a CD2-based signaling pathway which, in contrast to that of the T cell receptor, is independent of p56. CD2-mediated interleukin-2 production occurs via activation of Jun kinase in cell lines lacking p56. Jun kinase then facilitates the binding of c-Jun/c-Fos heterodimers to the AP-1 consensus site and the subsequent transcriptional activity of the interleukin-2 promoter. These data elucidate differences between TCR and CD2 signaling pathways in the same T cells.
Copper-Mediated Synthesis of <i>N</i>-Acyl Vinylogous Carbamic Acids and Derivatives:  Synthesis of the Antibiotic CJ-15,801 (2004)

ADVERTISEMENT RETURN TO ISSUEPREVAdditions & Corr...Additions & CorrectionsORIGINAL ARTICLEThis notice is a correctionCopper-Mediated Synthesis of N-Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ-15,801Chong Han, Ruichao Shen, Shun Su, and John A. PorcoCite this: Org. Lett. 2004, 6, 4, 649Publication Date (Web):January 17, 2004Publication History Published online17 January 2004Published inissue 1 February 2004https://pubs.acs.org/doi/10.1021/ol040007bhttps://doi.org/10.1021/ol040007bcorrectionACS PublicationsCopyright © 2004 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views448Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (6 KB) Get e-AlertscloseSUBJECTS:Antimicrobial agents Get e-Alerts
A Development and Characteristics of Remote Emergency Stop Device for Conveyors (2011)

Conveyors cause a high serious and fatal injuries in the industry. Every year people are hurt or killed as a result of accidents on conveyors. Most accidents occur during operation and maintenance when employees are working on moving, unguarded conveyors or when the conveyors starts unexpectedly. In 2008 there were 486 reported injures ranging from fatalities to injures. Of these 486 reported accidents, 8 were fatalities, 66.9%(325) of reported accidents occurred in manufacturing company and 43.8%(213) occurred at the belt conveyors. The objective of this study was to invent the remote emergency stop device because industrial accidents mainly occur at blind spots where usually do not have any safety guard or device rather than the normal working places. In principle, this new device will use with the existing safety system. Then, it will be powerful safety system for preventing injuries related with conveyors.
Acetylcholinesterase. Two types of modifications confer resistance to insecticide. (1992)

Quantitative and qualitative changes in acetylcholinesterase confer resistance to insecticides. We have constructed several Drosophila melanogaster strains producing various amounts of enzyme by P-mediated transformation. Toxicological analysis of these strains demonstrates that resistance to organophosphorus insecticides is correlated with the amount of acetylcholinesterase in the central nervous system. Resistance may also be qualitatively determined. Comparison of the Drosophila acetylcholinesterase gene between a resistant strain caught in the wild and a wild type susceptible strain only revealed one nucleotide transition resulting in the replacement of a phenylalanine by a tyrosine. Flies mutant for acetylcholinesterase and rescued with a minigene mutagenized for this same transition produced an altered enzyme which renders flies resistant to pesticides.
Effect of Electrical Stress on Josephson Tunneling Characteristics of ${\rm Nb/Al/AlO}_{x}/{\rm Nb}$ Junctions (2009)

Fabrication-induced variations in the critical currents of Josephson junctions significantly affect the performance and yield of complex superconducting integrated circuits. Electrical stress that may develop during plasma processing steps in the fabrication process was initially suggested as a possible cause of these variations. The effect on the Josephson and quasiparticle tunneling properties of Nb/Al/AlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /Nb junctions with ultrathin AlO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> barriers by the application of dc electrical stress was investigated. Current ramps with increasing amplitude corresponding to voltages across the barrier up to ~ 0.65 V were used to apply electrical stress. Junction conductance and current-voltage ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">V</i> ) characteristics were measured after each stress application at room temperature. As the stressing progresses, a dramatic increase in subgap conductance of the junctions, the appearance of subharmonic current steps, and a gradual increase in both the critical and the excess currents as well as a decrease in the normal-state resistance have been observed. A model is proposed wherein a progressively increasing number of defects and associated additional conduction channels (superconducting quantum point contacts (SQPCs)) are induced by the applied electric field in the tunnel barrier. The dependence of the stress effect on the polarity is also investigated and the results are presented. It is found that the magnitude of stress current needed for junction breakdown is unlikely to be supplied during plasma processing and as such, potential differences that can develop during plasma processing appear to be an unlikely cause of fabrication-induced, circuit pattern-dependent variations of Josephson junctions' critical currents in superconductor integrated circuits.
A statistical shape model of the heart and its application to model-based segmentation (2007)

In the present paper we describe the automatic construction of a statistical shape model of the whole heart built from a training set of 100 Multi-Slice Computed Tomography (MSCT) studies of pathologic and asymptomatic patients, including 15 (temporal) cardiac phases each. With these data sets we were able to build a compact and representative shape model of both inter-subject and temporal variability. A practical limitation in building statistical shape models, and in particular point distribution models (PDM), is the manual delineation of the training set. A key advantage of the proposed method is to overcome this limitation by not requiring them. Another one is the use of MSCT images, which thanks to their excellent anatomical depiction, have allowed for a realistic heart representation, including the four chambers and connected vasculature. The generalization ability of the shape model permits its deformation to unseen anatomies with an acceptable accuracy. Moreover, its compactness allows for having a reduced set of parameters to describe the modeled population. By varying these parameters, the statistical model can generate a set of valid examples. This is especially useful for the generation of synthetic populations of cardiac shapes, that may correspond <i>e.g.</i> to healthy or diseased cases. Finally, an illustrative example of the use of the constructed shape model for cardiac segmentation is provided.
CGC Perpendicular Recording Media With CoCrPt-SiO$_2$Alloy as Granular Layer (2006)

We investigated a new class of coupled granular/continuous (CGC) perpendicular media consisting of CoCrPt-SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> granular layer with magnetically decoupled small grains. By changing the number of Co/Pd bi-layers in the continuous layer, the degree of exchange coupling can be systematically controlled. The introduction of Co/Pd multilayer improved the nucleation field (H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> ) from -570 to -1670 Oe and K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">u</sub> V/k <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> T values from 67 to 97. Compared to the base granular media, the CGC media had 1 dB gain in signal-to-noise ratio (SNR) as well as 14 dB gain in write-ability (OW). Moreover, the output decay was reduced from -0.11 to -0.035 dB per decade. In CGC approach, a more appropriate strength of exchange coupling can be introduced that yields the significant improvement in both SNR and thermal stability
Problems in Antimicrobial Susceptibility Testing (1995)

From the Section of Microbiology, Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio
Cotyledons: an Explant for Routine Regeneration of Sunflower Plants (1992)

The potential of plant regeneration from sunflower cotyledon explants was studied under conditions either to allow direct regeneration (organogenesis) or callus proliferation with high regeneration capacity. Analysis of histological modifications caused by tissue culture conditions showed that the regeneration protocol described here permitted the development of abundant meristematic centers in discrete regions of the basal part of the cotyledon. The protocol presented here proved to be suitable for the regeneration of 10 genotypes, among 20 assayed, including commercial inbred lines and hybrids of common use for production in Argentina. Furthermore, Agrobacterium infection experiments showed that basal halves of cotyledons were transformed, evidencing tumour proliferation.
Direct Connection of Supercritical Fluid Extraction and Supercritical Fluid Chromatography as a Rapid Quantitative Method for Capsaicinoids in Placentas of <i>Capsicum</i> (1999)

The fruits of Capsicum annuum L. are used worldwide as chili peppers and in folk medicines. The pungent components of C. annuum, which are irritants, are called capsaicinoids (CAPS), and the most abundant components are capsaicin, dihydrocapsaicin, and nordihydrocapsaicin. To analyze CAPS in the placentas of Capsicum fruits rapidly and safely, we used a directly connected system of supercritical fluid extraction and supercritical fluid chromatography (SFE/SFC). As a column for SFE/SFC, only a silica-type column was found to be suitable. The CAPS contents in placentas of C. annuum cv. Jalapeno (hot type) and C. annuum cv. Shishitoh (less-hot type) determined by the SFE/SFC method agreed well with those in the range of 0-13.81 mg g(-1) fr. wt determined by the usual extraction-HPLC method. The SFE/SFC method has the advantages of no need for pretreatment and no (or minimal) need for organic solvents. We conclude that this method is useful as a rapid (20 min) and safe screening test for the pungency of various Capsicum fruits.
Engineering of a Novel Ruthenium Sensitizer and Its Application in Dye-Sensitized Solar Cells for Conversion of Sunlight into Electricity (2004)

A novel ligand 4,4'-bis(carboxyvinyl)-2,2'-bipyridine (L) and its ruthenium(II) complex [Ru(II)L(2)(NCS)(2)] (K8) were synthesized and characterized by analytical, spectroscopic, and electrochemical techniques. The performance of the K8 complex as a charge transfer photosensitizer in nanocrystalline TiO(2) based solar cells was studied. When the K8 complex anchored onto a nanocrystalline TiO(2) film, we achieved very efficient sensitization yielding 77 +/-5% incident photon-to-current efficiencies (IPCE) in the visible region using an electrolyte consisting of 0.6 M methyl-N-butyl imidiazolium iodide, 0.05 M iodine, 0.05 M LiI, and 0.5 M 4-tert-butylpyridine in a 50/50 (v/v) mixture of valeronitrile and acetonitrile. Under standard AM 1.5 sunlight, the complex K8 gave a short circuit photocurrent density of 18 +/- 0.5 mA/cm(2), and the open circuit voltage was 640 +/- 50 mV with fill factor of 0.75 +/- 0.05, corresponding to an overall conversion efficiency of 8.64 +/- 0.5%.
PDE7A1, a cAMP-specific Phosphodiesterase, Inhibits cAMP-dependent Protein Kinase by a Direct Interaction with C (2006)

The N-terminal regulatory region of the high affinity cAMP-specific phosphodiesterase, PDE7A1, contains two copies of the cAMP-dependent kinase (PKA) pseudosubstrate site RRGAI. In betaTC3 insulinoma cells, PDE7A1 co-localizes with PKA II in the Golgi-centrosome region. The roles PDE7A1 and its regulatory region play in cAMP signaling were examined by studying interactions with PKA subunits. PDE7A1 associates with the dissociated C subunit of PKA (C), but does not bind tetrameric PKA holoenzyme. High affinity binding of C by PDE7A1 inhibits kinase activity in vitro (IC50 = 0.5 nm). The domain containing PKA pseudosubstrate sites at the N terminus of PDE7A1 mediates complex formation with C. The PDE7A1 N-terminal repeat region inhibits C activity in CHO-K1 cells and also suppresses C dependent, cAMP-independent, physiological responses in yeast. Thus, PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C. This study identifies a novel inhibitor of PKA and a non-catalytic affect of a cyclic nucleotide phosphodiesterase.
The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism. (1991)

Metabolism of cGMP is critically important for the functioning of phototransduction in the mammalian retina. In rod and cone photoreceptors, two types of antagonistic enzymes, guanylate cyclases and cGMP phosphodiesterases, carefully balance the available amount of the intracellular messenger. Guanylate cyclase produces cGMP and phosphodiesterase rapidly hydrolyzes cGMP upon bleaching of the photopigment. Regulation of their activity in light and dark, influence of Ca++, and feed-back mechanisms are currently under intense investigation. A molecular analysis on both the gene and protein levels will contribute significantly to our understanding of their respective roles in phototransduction. The two types of enzymes have been characterized molecularly to a very different extent. Rod phosphodiesterase was purified to homogeneity almost fifteen years ago, but photoreceptor guanylate cyclase has evaded all attempts for molecular characterization. Characterization of retinal guanylate cyclase cDNA(s), however, will most likely be achieved in the near future. Cone PDE was shown to be a distinct enzyme, different from, but related to, the rod enzyme. Molecular cloning has provided sequence information of two of the three subunits of rod PDE; the small inhibitory subunit has been expressed in bacterial expression vectors, giving us an elegant tool for exploring mechanisms of activation and inhibition. The gene encoding the alpha subunit was shown to be a member of a large gene family of cyclic nucleotide phosphodiesterases, present in many eucaryotes ranging from unicellular organisms (yeast) to mammals. While much has been achieved, many questions remain to be answered. The beta subunit of rod phosphodiesterase has evaded complete molecular characterization, and its origin (one gene and posttranslational modification of the gene product generating alpha and beta, alternative splicing, or two separate genes with distinct gene products) has not been elucidated. Mechanisms of interaction of subunits, activation and inhibition, the active site(s) of the enzyme are undefined. Virtually nothing is known about the molecular organization of the photoreceptor guanylate cyclase(s). Recent cloning of two apparently unrelated mammalian guanylate cyclases, however, containing a common homologous domain signals increasingly rapid progress in this field.
Fabrication of wedged multilayer Laue lenses (2015)

We present a new method to fabricate wedged multilayer Laue lenses, in which the angle of diffracting layers smoothly varies in the lens to achieve optimum diffracting efficiency across the entire pupil of the lens. This was achieved by depositing a multilayer onto a flat substrate placed in the penumbra of a straight-edge mask. The distance between the mask and the substrate was calibrated and the multilayer Laue lens was cut in a position where the varying layer thickness and the varying layer tilt simultaneously satisfy the Fresnel zone plate condition and Bragg’s law for all layers in the stack. This method can be used to extend the achievable numerical aperture of multilayer Laue lenses to reach considerably smaller focal spot sizes than achievable with lenses composed of parallel layers.
ChemInform Abstract: A KNOEVENAGEL‐TYPE SYNTHESIS OF STYRENE‐OMEGA‐SULFONANILIDES (1975)

Abstract Bromessigsäureester (I) werden mit Natriumsulfit in die Sulfonate (II) umgewandelt, die über die Zwischenstufe der Sulfochloride (III) in die Sulfonanilide (V) übergeführt werden.
Controlling the magnetic-field sensitivity of atomic-clock states by microwave dressing (2014)

We demonstrate control of the differential Zeeman shift between clock states of ultracold rubidium atoms by means of nonresonant microwave dressing. Using the dc field dependence of the microwave detuning, we suppress the first- and second-order differential Zeeman shift in magnetically trapped $^{87}\mathrm{Rb}$ atoms. By dressing the state pair $5{S}_{1/2}$ $F=1$, ${m}_{F}=\ensuremath{-}1$ and $F=2$, ${m}_{F}=1$, a residual frequency spread of $<0.1$ Hz in a range of 100 mG around a chosen magnetic offset field can be achieved. This is one order of magnitude smaller than the shift of the bare states at the magic field of the Breit-Rabi parabola. We further identify double magic points, around which the clock frequency is insensitive to fluctuations both in the magnetic field and in the dressing Rabi frequency. The technique is compatible with chip-based cold-atom systems and allows the creation of clock and qubit states with reduced sensitivity to magnetic-field noise.