gebhart/patrepeval huggingface dataset:
Fluorochemicals-Today and Tomorrow (1953)

RETURN TO ISSUEPREVNewsNEXTFluorochemicals-Today and TomorrowTHOMAS J. BRICE, HUGH G. BRYCE, and HAROLD M. SCHOLBERGView Author Information Minnesota Mining & Manufacturing Co., St. Paul, Minn.Cite this: Chem. Eng. News 1953, 31, 6, 510–513Publication Date (Print):February 9, 1953Publication History Published online5 November 2010Published inissue 9 February 1953https://pubs.acs.org/doi/10.1021/cen-v031n006.p510https://doi.org/10.1021/cen-v031n006.p510newsACS PublicationsCopyright © 1953 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Fluorine,Hydrogen,Molecules,Organic compounds,Stability Get e-Alerts
Bilateral Dislocation of Rear Tip Extenders from the Inflatable Penile Prosthesis (1982)

No AccessJournal of Urology1 Dec 1982Bilateral Dislocation of Rear Tip Extenders from the Inflatable Penile Prosthesis David Joseph and Reginald C. Bruskewitz David JosephDavid Joseph and Reginald C. BruskewitzReginald C. Bruskewitz View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53479-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Rear tip extenders have been developed recently for placement at the base of the cylinders of the inflatable penile prosthesis. These are designed to diminish the chance of the cylinder tube rubbing on and subsequently perforating through the expandable portion of the penile prosthesis cylinder. We report a case in which spontaneous dislodgement of the rear tip extenders from the cylinders of the inflatable penile prosthesis occurred. © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 128Issue 6December 1982Page: 1317-1318 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information David Joseph More articles by this author Reginald C. Bruskewitz More articles by this author Expand All Advertisement PDF downloadLoading ...
Bell (2006)

Memory leaks compromise availability and security by crippling performance and crashing programs. Leaks are difficult to diagnose because they have no immediate symptoms. Online leak detection tools benefit from storing and reporting per-object sites (e.g., allocation sites) for potentially leaking objects. In programs with many small objects, per-object sites add high space overhead, limiting their use in production environments.This paper introduces Bit-Encoding Leak Location (Bell), a statistical approach that encodes per-object sites to a single bit per object. A bit loses information about a site, but given sufficient objects that use the site and a known, finite set of possible sites, Bell uses brute-force decoding to recover the site with high accuracy.We use this approach to encode object allocation and last-use sites in Sleigh , a new leak detection tool. Sleigh detects stale objects (objects unused for a long time) and uses Bell decoding to report their allocation and last-use sites. Our implementation steals four unused bits in the object header and thus incurs no per-object space overhead. Sleigh's instrumentation adds 29% execution time overhead, which adaptive profiling reduces to 11%. Sleigh's output is directly useful for finding and fixing leaks in SPEC JBB2000 and Eclipse, although sufficiently many objects must leak before Bell decoding can report sites with confidence. Bell is suitable for other leak detection approaches that store per-object sites, and for other problems amenable to statistical per-object metadata.
Role of Serotonin in the Behavioral and Psychological Symptoms of Dementia (2001)

The behavioral and psychological symptoms of dementia (BPSD) can have serious debilitating effects on the patient and increase caregiver burden. Investigations into the underlying neuropathology indicate that the serotonergic system may contribute to BPSD. In addition, serotonergic pathways are known to interact extensively with the cholinergic, noradrenergic, GABAergic, and dopaminergic systems. Hence, serotonergic therapies may be used to manipulate other neurotransmitters systems to alleviate BPSD or in combination with agents specific for the other neurotransmitter receptor sites. Neurotransmitter-modulated behaviors and evidence provided by pharmacological interventions are reviewed, focusing primarily on the serotonergic system.
Construction of exogenous multiple epitopes of helper T lymphocytes and DNA immunization of its chimeric plasmid with HBV pre-S2/S gene (2004)

Exogenous multiple epitopes of HTL had immune enhancement when they were co-inoculated with pre-S2/S gene or inoculated in the chimeric form at a proper site of pre-S2/S gene of HBV. It might suggest that it was possible to improve hepatitis B vaccine using exogenous multiple epitopes of HTL. The antibody responses were very low using DNA immunization in the study. Thus, the immune enhancement effect of exogenous multiple epitopes of HTL has to be confirmed and the effect on overcoming the drawback of the polymorphism of HLA II antigens should also be evaluated after these chimeric plasmids are expressed in mammalian cell lines.
Design and feasibility (1993)

The Malmö Diet and Cancer study is a 10-year prospective case-control study in 45-64-year-old men and women (n = 53,000) living in a city with 230,000 inhabitants. One objective is to clarify whether a western diet is associated with certain forms of cancer whilst taking other life-style factors into account. Another broad question is whether oxidative stress and the activity in DNA-repairing systems influence the impact of diet on the development of all or certain forms of cancer. The study is also to act as a resource available for testing new hypotheses emanating from other studies. Initially food intake, heredity, socio-economic factors, life-style pattern, occupational situation, previous and current diseases, symptoms and medications, will be determined. Viable lymphocytes, granulocytes, erythrocytes, and plasma/serum will be stored in a biological bank together with tumour specimens gathered from cases. The incidence and mortality of all cancer forms will then be followed for 10 years by existing registries. Data from the initial examination in these cases will then be compared with those of control subjects not having developed any form of cancer. A biomarker programme, utilizing the biological bank, has been developed and is aimed at finding predictors and/or precursors of cancer. A high participation rate (> 70%) and a high quality biological bank are prerequisites for a successful project. The experience gathered so far indicates that these goals are feasible.
Mass Spectrometric and Kinetic Analysis of ASF/SF2 Phosphorylation by SRPK1 and Clk/Sty (2005)

Assembly of the spliceosome requires the participation of SR proteins, a family of splicing factors rich in arginine-serine dipeptide repeats. The repeat regions (RS domains) are polyphosphorylated by the SRPK and Clk/Sty families of kinases. The two families of kinases have distinct enzymatic properties, raising the question of how they may work to regulate the function of SR proteins in RNA metabolism in mammalian cells. Here we report the first mass spectral analysis of the RS domain of ASF/SF2, a prototypical SR protein. We found that SRPK1 was responsible for efficient phosphorylation of a short stretch of amino acids in the N-terminal portion of the RS domain of ASF/SF2 while Clk/Sty was able to transfer phosphate to all available serine residues in the RS domain, indicating that SR proteins may be phosphorylated by different kinases in a stepwise manner. Both kinases bind with high affinity and use fully processive catalytic mechanisms to achieve either restrictive or complete RS domain phosphorylation. These findings have important implications on the regulation of SR proteins in vivo by the SRPK and Clk/Sty families of kinases.
Leveraging Smart-Meters for Initiating Application Migration across Clouds for Performance and Power-Expenditure Trade-Offs (2010)

Smart meters, introduced by smart grid technologies, enable power distribution companies to price electricity differently for different times of the day. Such dynamic pricing schemes help the power companies to modulate the aggregate demand of electricity based on the supply. Accordingly, cloud providers, which are often the largest consumers of electricity, should be able to respond to various dynamic pricing signals called demand response (DR) signals by autonomously moving identified applications to other cloud sites. This paper leverages the recent advancements in cloud migration technologies to 'intelligently' move applications across geographically distributed cloud sites at runtime after a DR signal is received by the cloud provider. This helps minimize the cost incurred by a cloud provider and yet provide adequate service level guarantees as stated in the service level agreements (SLA). The current work develops models and solution schemes for identifying suitable applications for migration and placing such applications on remote cloud sites to take advantages of pricing schemes such as the time-of-use pricing and real time pricing.
Antiaggregatorische und anticoagulante Eigenschaften von Oligoaminen, 6. Mitt.: Oligohydroxyalkandiamine (1987)

Abstract Es wurden 17 oligohydroxylierte Alkandiamine dargestellt, von denen acht die durch Collagen induzierte Thrombocytenaggregation in Konzentrationen unter 10 μmol/L halbmaximal hemmten. Sieben dieser Substanzen setzten die Gerinnungsfähigkeit von Blutplasma – dargestellt als Verlängerung der Thromboplastinzeit – in Konzentrationen zwischen 50 und 400 μmol/L auf 25 % der Norm herab. Mit 1,4‐Bisoctylaminobutan‐2,3‐diol ( 16 ) wurde eine Substanz mit starker Thrombocytenwirkung (IC 50 = 9 μmol/L) jedoch ohne anticoagulante Effekte gefunden. 16 zeigt auch die durch die Einführung der Hydroxylfunktionen angestrebte Verbesserung der Wasserlöslichkeit (55 mmol/L) am deutlichsten.
Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C (2014)

ClinicalTrials.gov identifier: NCT02161952. Protocol Registration Date: 06/11/2014.
Construction of Regular and Irregular LDPC Codes: Geometry Decomposition and Masking (2007)

Two algebraic methods for systematic construction of structured regular and irregular low-density parity-check (LDPC) codes with girth of at least six and good minimum distances are presented. These two methods are based on geometry decomposition and a masking technique. Numerical results show that the codes constructed by these methods perform close to the Shannon limit and as well as random-like LDPC codes. Furthermore, they have low error floors and their iterative decoding converges very fast. The masking technique greatly simplifies the random-like construction of irregular LDPC codes designed on the basis of the degree distributions of their code graphs
Characterization and Serological Detection of Four Closterovirus‐like Particles Associated with Leafroll Disease on Grapevine (1990)

Abstract Four serologically unrelated closterovirus‐like particles (GLRV‐1, GLRV‐2, GLRV‐3 and GLRV‐4) were isolated in our laboratory from leafroll diseased grapevines. Polyclonal antibodies raised against these particles were useful for their characterization and their detection in infected plants. The coat proteins of these four serotypes were characterized by a SDS‐PAGE after denaturation, followed by a transfer on nitrocellulose sheet and immunoprinting using the specific polyclonal antibodies. The capsid of GLRV‐1, GLRV‐2, GLRV‐3 and GLRV‐4 contains a single protein species with molecular weight of about 39 Kd, 26 Kd, 43 Kd and 36 Kd respectively. No serological relation was found between these four filamentous particles either by ELISA, immuno electron microscopy or immunoblotting experiments. Serological analysis of many grapevines originating from the Middle East and Europe showed a very close association between the presence of GLRV‐1, GLRV‐2, GLRV‐3 and GLRV‐4 antigens, and leafroll symptoms on Vitis vinifera Pinot Noir. This association was confirmed by testing symptomless and diseased grapevines collected in the field, and by serological analysis of heat treated plants originally infected by GLRV‐1 and GLRV‐3, which are the most widespread antigens detected in leafroll infected grapevines.
Blood optical properties at various glucose level values in THz frequency range (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. I. Gusev, M. A. Borovkova, M. A. Strepitov, and M. K. Khodzitsky, "Blood optical properties at various glucose level values in THz frequency range," in Clinical and Biomedical Spectroscopy and Imaging IV, J. Brown and V. Deckert, eds., Vol. 9537 of SPIE Proceedings (Optica Publishing Group, 2015), paper 95372A. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The effects of interferon beta treatment on arthritis (1999)

The data suggest that IFN-beta treatment has a beneficial effect on arthritis.
ADJUSTING TO CHANGE: HOW SMALL FIRMS MIGHT GET AROUND THE (POTENTIAL) MARKETING MYOPIA PROBLEM (1995)

The response or non‐response of small businesses to change is an important area of study. Environmental analysis is a crucial corollary to business development and growth. However, experience of small firms has indicated that the managers of such enterprises may become myopic in relation to changes in the business environment, or may not respond to or notice slow change. This myopia or lethargy exhibited by small firms needs to be avoided if such firms are to survive and grow. Four crucial questions (where is the firm now; where is it heading if it takes no action to change things; where do we want the firm to be; and how might we take it there?) must be answered if small firms wish to survive and grow. It is recommended that environmental analysis coupled with the use of a creativity consultant may help small firms to develop strategies for adjusting to change and avoiding marketing myopia.
Endothelin-Stimulated ERK Activation in Airway Smooth-Muscle Cells Requires Calcium Influx and Raf Activation (1999)

Endothelin (ET)-1 is a 21-amino-acid peptide that is a potent vasoconstrictor and mitogen. By binding to its G-protein coupled receptor, ET-1 stimulates the proliferation of airway smooth-muscle (ASM) cells, which may be involved in the pathogenesis of asthma. The ETB receptor stimulates activation of the extracellular regulated kinase 2 (ERK2), which is thought to be required for proliferation of ASM cells. Our findings reveal that ET rapidly activates Raf, and that dominant-negative Raf interferes with ET-induced ERK activation in ASM cells. Expression of the amino-terminal Ras-binding domain of Raf inhibited ET-induced ERK activation, suggesting that ET-stimulated Raf activation is a Ras-dependent process. Furthermore, ET-stimulated ERK and Raf activation in ASM cells require calcium influx; chelating extracellular calcium or preventing calcium influx through calcium channels inhibited ET-stimulated, but not phorbol ester-stimulated, ERK and Raf activation.
The Equivalency of Two <scp>L</scp>-Thyroxine Preparations (1985)

Differences in blood levels of thyroid hormones have been reported when patients taking synthetic L-thyroxine were shifted from one manufactured form of the hormone to another. Because recent formulation changes have rendered these earlier data obsolete, we did a crossover study to determine differences in bioavailability of the two principal brands of thyroxine, Synthroid and Levothroid. Twenty patients received Synthroid and then Levothroid, and 14 received Levothroid and then Synthroid. Patients received each drug for 6 weeks. Although no significant differences were seen in routine thyroid hormone measurements, combined data from both groups showed a significantly higher free thyroxine level in the patients treated with Synthroid, as well as lower thyrotrophin values at 15 and 30 minutes after administration of thyrotrophin-releasing hormone. Equal doses of the currently manufactured forms of these two products are similar but not bioequivalent.
Effect of the Magnetostrictive Layer on Magnetoelectric Properties in Lead Zirconate Titanate/Terfenol‐D Laminate Composites (2001)

Magnetoelectric laminate composites of piezoelectric/magnetostrictive materials were prepared by stacking and bonding together a PZT disk and two layers of Terfenol‐D disks with different directions of magnetostriction. These composites were studied to investigate (i) dependence on the magnetostriction direction of the Terfenol‐D disk and (ii) dependence on the direction of the applied ac magnetic field. Three different types of assemblies were prepared by using two types of disks: one with magnetostriction along the radial direction, the other with magnetostriction along the thickness direction. The maximum magnetoelectric voltage coefficient (d E /d H ) of 5.90 V/cm·Oe was obtained for a design where the composite was made by two Terfenol‐D layers with a radial magnetostriction direction.
FEBRILE TRANSFUSION REACTIONS CAUSED BY SENSITIVITY TO DONOR LEUKOCYTES AND PLATELETS (1957)

The hypothesis that some otherwise unexplained febrile reactions to blood transfusions may be caused by isoimmunization of patients against the donors' leukocytes was tested in 10 patients who needed transfusions. Five patients (group A) had previously had from 20 to 85 transfusions, had histories of repeated transfusion reactions, and had demonstrable antibodies against the specific normal leukocytes administered during this study. The other five patients (group B) had had only seven or less previous transfusions, with no histories of transfusion reactions. Group A did not experience adverse effects when the blood used for transfusion was so prepared, by centrifuging, as to remove as much as possible of the buffy layer, but all reacted with fever, typical symptoms, and characteristic laboratory findings to subsequent transfusion of the buffy coat which had been so removed. Group B did not react adversely to either fraction of the donors' blood. Immunologic evidence suggested that it was the leukocytes rather than the platelets in the buffy layer that caused the reactions. Techniques for removing the buffy coat when blood is prepared for transfusion offer a means of preventing the dangerous reactions that occur when patients, after multiple transfusions, become isoimmunized to donor leukocytes.
The use of Farm Business Survey data to compare the environmental performance of organic and conventional farms (2012)

This paper considers two main questions: Is it possible to use Farm Business Survey (FBS) data to derive well-established environmental indicators and can these FBS derived indicators also provide a reasonable comparison of the environmental performance of organic and conventional farms? The results suggest that the indicators can be obtained from FBS data and that the majority of the indicators provided meaningful results, despite some data limitations within the FBS dataset. The comparison of organic with conventional FBS data in the UK suggests that organic farms have lower fertiliser and crop protection costs (as would be expected) but that differences in feed costs, stocking density and cropping diversity were dependent upon farm type. This research confirms that FBS data can be used to derive indirect environmental indicators which are able to identify significant differences between farm types and management systems. These indicators are also likely to be applicable at EU level through their use within the Farm Accountancy Data Network (FADN), which collates farm economic data across the EU. This is of interest to researches and policy-makers who could use FADN data to track some aspects of environmental performance across many countries and track changes over time. These results may also be useful to farm consultants and managers who could potentially use a similar approach in using individual farm financial information to benchmark some aspects of farm environmental performance.
Salting‐out assisted liquid/liquid extraction with acetonitrile: a new high throughput sample preparation technique for good laboratory practice bioanalysis using liquid chromatography–mass spectrometry (2008)

Acetonitrile, an organic solvent miscible with aqueous phase, has seen thousands of publications in the literature as an efficient deproteinization reagent. The use of acetonitrile for liquid-liquid extraction (LLE), however, has seen very limited application due to its miscibility with aqueous phase. The interest in LLE with acetonitrile has been pursued and reported in the literature by significantly lowering the temperature of the mixture or increasing the salt concentration in the mixture of acetonitrile and aqueous phase, resulting in the separation of the acetonitrile phase from aqueous phase, as observed in conventional LLE. However, very limited application of these methods has been reported. The throughput was limited. In this report, we report a new sample preparation technique, salting-out assisted liquid-liquid extraction with acetonitrile, for high-throughput good laboratory practice sample analysis using LCMS, Two compounds from an approved drug, Kaletra, were used to demonstrate the extractability of drugs from human plasma matrix. Magnesium sulfate was used as the salting-out reagent. Extracts were diluted and then injected into a reversed phase LC-MS/MS system directly. One 96-well plate was extracted with this new approach to evaluate multiple parameters of a good laboratory practice analytical method. Results indicate that the method is rapid, reliable and suitable for regulated bioanalysis. With minimal modification, this approach has been used for high-throughput good laboratory practice analysis of a number of compounds under development at Abbott.
A graphical method for solution of freezing problems (1958)

Abstract Problems in heat conduction involving a moving boundary are encountered in the freezing of liquids and in other situations. Such problems are difficult to solve, and exact solutions are almost unknown. A graphical method for obtaining numerical solutions to problems of this type which can be described in terms of one space coordinate is derived and is demonstrated in two examples involving the freezing of liquids. The method, which does not require specialized knowledge or equipment, takes into account both sensible heats and latent heat.