gebhart/patrepeval huggingface dataset:
Syntheses and .BETA.-adrenoceptor activities of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. (1977)

In connection with our earlier studies on β-adrenergic-stimulating activities of ringclosed analogs of β-hydroxycatecholamines, a series of 2-amino-and 2-alkylamino-1, 2, 3, 4-tetrahydro-1-naphthalenols was synthesized with the aim of finding new bronchodilators with minimal cardiovascular side effects. The present paper includes compounds possessing a hydroxy group at the 6-position and a hydroxymethyl, cyano or ureidomethyl group at the 5-position. As starting materials, 6-methoxy-3, 4-dihydro-1 (2H)-naphthalenone and methyl 2-hydroxy-1-naphthoate were used. The latter was more advantageous for the synthesis of 5-hydroxymethyl derivatives. Stereoselective reduction of the 1-ketone to give cis-or trans-2-amino-1-hyroxy compounds was also discussed.
The productivity and career development of women in science and technology (2010)

In the 21st century the role of women in science and technological (WIST) field are very important. They are technical workforce in the labor market. Many countries are actively promoting policy of women in higher education and R&D careers. Utilization of the talents of women should not be viewed only from the perspective of gender equity. In the rapid economic development today, WIST's productivity and career development must be understood. This research paper is to understand the contribution of WIST and suggest organization provides suitable career development programs to reduce their intention to leave. The goal is increasing WIST's visibility and participation in science and technological field. The principal theme presented in the paper is career of women in science and technology (WIST). To evaluate the career gap which the differences between careers needs and career development programs. Moreover, it is exam the relationship of career development gap and turnover intention.
<i>In vivo</i> blood viscosity characterization based on frequency-resolved photoacoustic measurement (2018)

In this letter, we proposed a photoacoustic (PA) method for noninvasively detecting blood viscosity in subcutaneous microvasculature with the frequency-resolved measurement. The influence of viscosity on PA generation was investigated theoretically, and a negative correlation was shown between the viscosity and the full width at half maximum (FWHM) of the PA frequency spectrum, which can be utilized to reflect the viscosity distribution. To test the feasibility and accuracy of this method, water mixed with different concentrations of glycerol was measured. FWHM of the PA frequency spectrum was also obtained in vivo in the mouse ear to characterize the blood viscosity from different vessel bifurcations, and the metabolism-induced viscosity changes were dynamically monitored in the microvasculature. Experimental results demonstrate that this technique has future potential clinical applications for real-time monitoring the viscosity changes in subcutaneous microvasculature.
Imaging and analysis of subsurface Cu interconnects by detecting backscattered electrons in the scanning electron microscope (2005)

Cu – Si O 2 – Si N x interconnects that were located 0.65–2.7-μm below the surface of silicon-integrated circuits were imaged in a scanning electron microscope and a transmission electron microscope with a scanning attachment by detecting backscattered electrons (BSEs) with an incident electron-beam energy (Eo) in the range of 30–400keV. BSE images could be used to detect voids in subsurface Cu interconnects, even in regions covered with upper level Cu lines or vias. As Eo was increased from 30to400keV, structures could be seen as a result of atomic number (Z) contrast farther below the surface while structures closer to the surface had reduced Z contrast. The subsurface beam diameter was measured from BSE images as a function of Eo and depth below the surface. For all Eo, the subsurface beam diameter initially rapidly increased with SiO2 overlayer thickness but, for 150keV, a leveling off in the beam spread was seen for depths &gt;1.7μm. Beam broadening affected whether the TaN∕Ta liners that surrounded the Cu conductors could be seen at the edges of the lines; this contrast was observed only when the subsurface beam diameter was ⩽1.5× the liner thickness. The BSE information depth for imaging 0.2-μm-sized voids in subsurface Cu–SiO2–SiNx interconnect structures at 30 and 150keV was estimated to be 0.65 and 3μm, respectively.
Computational Symmetry in Computer Vision and Computer Graphics (2008)

In the arts and sciences, as well as in our daily lives, symmetry has made a profound and lasting impact. Likewise, a computational treatment of symmetry and group theory (the ultimate mathematical formalization of symmetry) has the potential to play an important role in computational sciences. Though the term Computational Symmetry was formally defined a decade ago by the first author, referring to algorithmic treatment of symmetries, seeking symmetry from digital data has been attempted for over four decades. Computational symmetry on real world data turns out to be challenging enough that, after decades of effort, a fully automated symmetry-savvy system remains elusive for real world applications. The recent resurging interests in computational symmetry for computer vision and computer graphics applications have shown promising results. Recognizing the fundamental relevance and potential power that computational symmetry affords, we offer this survey to the computer vision and computer graphics communities. This survey provides a succinct summary of the relevant mathematical theory, a historic perspective of some important symmetry-related ideas, a partial yet timely report on the state of the arts symmetry detection algorithms along with its first quantitative benchmark, a diverse set of real world applications, suggestions for future directions and a comprehensive reference list.
Second-Order Peak Detection for Multicomponent High-Resolution LC/MS Data (2006)

The first step when analyzing multicomponent LC/MS data from complex samples such as biofluid metabolic profiles is to separate the data into information and noise via, for example, peak detection. Due to the complex nature of this type of data, with problems such as alternating backgrounds and differing peak shapes, this can be a very complex task. This paper presents and evaluates a two-dimensional peak detection algorithm based on raw vector-represented LC/MS data. The algorithm exploits the fact that in high-resolution centroid data chromatographic peaks emerge flanked with data voids in the corresponding mass axis. According to the proposed method, only 4 per thousand of the total amount of data from a urine sample is defined as chromatographic peaks; however, 94% of the raw data variance is captured within these peaks. Compared to bucketed data, results show that essentially the same features that an experienced analyst would define as peaks can automatically be extracted with a minimum of noise and background. The method is simple and requires a priori knowledge of only the minimum chromatographic peak width-a system-dependent parameter that is easily assessed. Additional meta parameters are estimated from the data themselves. The result is well-defined chromatographic peaks that are consistently arranged in a matrix at their corresponding m/z values. In the context of automated analysis, the method thus provides an alternative to the traditional approach of bucketing the data followed by denoising and/or one-dimensional peak detection. The software implementation of the proposed algorithm is available at http://www.anchem.su.se/peakd as compiled code for Matlab.
Layerwise Monitoring of Polymer Laser Sintering Using Thermal Imaging (2014)

Polymer Laser Sintering (LS) is used increasingly for manufacture of end-use parts. Improved methods of monitoring the process are needed to certify the quality of these parts. This paper describes the use of high resolution infrared thermal imaging to monitor the temperature of individual layers before, during and after laser scanning. The time-temperature history of each point in a layer depends on process parameters and part geometry. This history also controls the sintering and crystallization process for a single volume element of the part and its mechanical properties. Proposed new process control schemes may use this monitoring data to ensure that all volume elements achieve full density. The proposed framework includes creating a 3D template of the input model. This template simulates the part fabrication in the SLS machine. Registration of this template to the monitor data creates a 3D quality certificate for the part.
Engineering the Rapid Adenovirus Production and Amplification (RAPA) Cell Line to Expedite the Generation of Recombinant Adenoviruses (2017)

The RAPA cells are highly efficient for adenovirus production and amplification.
Assessment of left ventricular function by echocardiography in the emergency room (2001)

AIM To investigate the valuability and feasibility of echocardiography for left ventricular function assessment in the patients admitted to the emergency room. METHODS 121 consecutive patients with heart failure (109 cases) and first AMI (12 cases) underwent two dimensional Doppler echocardiography of global left ventricular systolic, diastolic function and regional wall motion abnormality. during 24 hours. RESULTS Of 116 patients (95.9%), 104 cases with heart failure and 12 cases with the first AMI were studied. The main causes of heart failure were hypertensive heart disease (HHD), ischemia heart disease (IHD) and pulmonary heart disease (PHD), respectively 48%, 19% and 21%. Of the heart failure patients, 16 cases (15%) were the pure diastolic dysfunction without systolic dysfunction, which had not been diagnosed clinically. The regional wall motion abnormality in the patients with AMI was detected by echocardiography in 7 cases of AMI with RWMSI1 after 6 h but not in 5 cases within 6 h. CONCLUSION It is valuable and feasibile for evaluation of left ventricular function by echocardiography in the patients admitted to the emergency room, especially for the diagnosis of pure diastolic dysfunction. However regional wall motion abnormality evaluated by echocardiography may not increase the confidence of thrombolisis and diagnosis of AMI during 6 h.
Possible relationship of poly(A) shortening to mRNA turnover. (1975)

Whereas the original size of poly(A) in HeLa cells is about 200 nucleotides, at steady state most of the poly(A) in mRNA contains less than 50 nucleotides. An endonucleolytic attack on poly(A) is suggested as the most likely method to accumulate short pieces of poly(A). Both poly(A) shortening and mRNA turnover appear to be inhibited by emetine, a drug that stops translation. It is possible that a random endonucleolytic attack leads to scission of poly(A) to a size below which the mRNA is unstable.
Pharmacologic Myocardial Preconditioning with Monophosphoryl Lipid A (MLA) Reduces Infarct Size and Stunning in Dogs and Rabbits (1996)

As the mechanism of ischemic preconditioning unfolds, various strategies for inducing pharmacologic preconditioning become apparent. Adenosine receptor agonists, KATP channel activators, and endothelial-neutrophil adhesion antagonists have enjoyed cardioprotective activity against ischemia/reperfusion injury in at least some preclinical models. Monophosphoryl lipid A (MLA), a structural derivative of the pharmacophore of endotoxin, enjoys an improved therapeutic index in relation to the parent biological product. MLA has found clinical application as a vaccine adjuvant and protects from sepsis and septic shock in the preclinical setting. In animal models of myocardial ischemia/reperfusion injury, pretreatment 12-24 hours prior to ischemia with a single IV bolus injection of MLA limits infarct size 50 to 75 percent in standard canine and rabbit models at doses of 10-35 micrograms/kg. Regional myocardial stunning following multiple 5-minute ischemic episodes as assessed by segment shortening is reduced in dogs pretreated 24 but not 1 hour prior to ischemia. Global cardiac function, as evaluated by pressure-volume constructs generated in dogs being weaned from cardiopulmonary bypass, recovers more quickly in animals pretreated with MLA. Cardiac protection in various models is associated with preservation of ATP during ischemia, induction of 5' nucleotidase and enhancement of calcium reuptake by SR during reperfusion. Limitation of infarct size by MLA in dogs and rabbits can be reversed by the administration of glibenclamide just prior to ischemia, suggesting a role for KATP channel opening during the first minutes of sustained ischemia. A clinical formulation of MLA (MPL-C) is currently undergoing clinical investigation in the Phase II setting in coronary artery bypass surgical patients. MLA may represent a novel means of inducing pharmacologic preconditioning, with potential for clinical application as a pretreatment before planned myocardial ischemia.
Specialist deterrent chemoreceptors enable <i>Pieris</i> caterpillars to discriminate between chemically different deterrents (1999)

Abstract Pieris butterflies (Lepidoptera: Pieridae) are specialist herbivores of cruciferous plants. They exploit glucosinolates, secondary plant metabolites chemotaxonomically characteristic for this plant family, as token stimuli. In addition to particular glucosinolates, some genera of the Cruciferae contain cardenolides, steroidal allelochemicals that act as potent feeding and oviposition deterrents to several Pieris species. We investigated the sensory mechanisms by which these compounds are perceived in larvae. Pieris caterpillars and many other lepidopterous species are endowed with so‐called generalist deterrent receptors, that respond to a broad spectrum of secondary plant substances. In Pieris caterpillars we found a second type of deterrent chemoreceptor in maxillary styloconic taste sensilla. This neuron is very sensitive to cardenolides (threshold 0.1–0.3 μM). The generalist deterrent receptor also responds to these substances but its threshold lies at 50–100× higher concentrations. In behavioural preference experiments Pieris brassicae L. caterpillars preferred cardenolide‐treated cabbage leaf discs when confronted with a choice between them and a deterrent substance that does not occur in the Brassicaceae. The cardenolides acted as potent deterrents when offered against untreated cabbage leaf discs. This demonstrates that the balance of activity elicited in the two types of deterrent chemoreceptors determines the behavioural decision.
Programming Tips (1983)

The names of variables are usually single letters, but occasionally combinations of letters, or letters and digits are used. For example, $$ \begin{array}{*{20}{c}} {30{\rm{ SCORE = 0}}}\\ {40{\rm{ G2 = 4}}{\rm{.7}}} \end{array} $$ might be typical program lines.
Some considerations concerning volume-modulated arc therapy: a stepping stone towards a general theory (2009)

In this paper it is formally shown that the dynamic multileaf collimator (MLC) IMRT delivery technique remains valid if the MLC is supported on a 1D moving platform. It is also shown that, in such circumstances, it is always time preferable to deliver overlapping modulating fields as a single swept field rather than as separate fields. The most general formulism is presented and then related to simpler equations in limiting cases. The paper explains in detail how a 'small-arc approximation' can be invoked to relate the 1D linear theory to the MLC-on-moving-platform-(gantry) delivery technique involving rotation therapy and known as volume-modulated arc therapy (VMAT). It is explained how volume-modulated arc therapy delivered with open unmodulated fields and which can deliver conformal dose distributions can be interpreted as an IMRT delivery. The (Elekta adopted) term VMAT will be used in a generic sense to include a similar (Varian) method known as RapidArc. Approximate expressions are derived for the 'amount of modulation' possible in a VMAT delivery. This paper does not discuss the actual VMAT planning but gives an insight at a deep level into VMAT delivery. No universal theory of VMAT is known in the sense that there is no theory that can predict precisely the performance of a VMAT delivery in terms of the free parameters available (variable gantry speed, variable fluence-delivery rate, set of MLC shapes, MLC orientation, number of arcs, coplanarity versus non-coplanarity, etc). This is in stark contrast to the situation with several other IMRT delivery techniques where such theoretical analyses are known. In this paper we do not provide such a theory; the material presented is a stepping stone on the path towards this.
DESENVOLVIMENTO DA LEITURA E DA ESCRITA NA ALFABETIZAÇÃO: DESAFIOS E POSSIBILIDADES (2018)

O trabalho diz respeito a leitura e a escrita na sala de aula da alfabetizacao, como atender as necessidades dos alunos em relacao ao desenvolvimento de suas habilidades e competencias nos campos de leitura e da escrita, desenvolvendo no educando a capacidade de realizar trabalhos escritos, associacao de ideias, clareza, coesao e coerencia, fazer do aluno um individuo apto a decidir sobre suas escolhas, necessidades cotidianas e outros, envolver a escola em projetos que estimulem o gosto da leitura e escrita. Esta pesquisa tem como objetivo, analisar os desafios e as possibilidades do ensino-aprendizagem da leitura e da escrita durante as series iniciais, fazer um breve levantamento sobre o assunto, entender a diferenca entre alfabetizacao e letramento e relacionar as praticas pedagogicas de leitura e de escrita que colaborem para o letramento. Este trabalho foi baseado nos seguintes autores CAGLIARI (2007) (2002) e (1998), SOARES (2003), TEBEROSKI (1999), PEREZ (1992) MENDONCA (2007) KLEIMAN (1995) (2001) e (2007), FREITAG (1998), VYGOTSKY (2000) e dentre outros. Foi realizado tambem pesquisas na internet, e teve-se como base o site do MEC, IBGE e os PCN’s. Tendo em vista que e uma ferramenta fundamental nas escolas, a leitura e a escrita e de suma importância para a formacao dos alunos, pois, estes sairao das escolas aptos a desenvolver a criticidade, autonomia, e ampliando a capacidade de se interagir e se expressar melhor, assim tornando-se capaz de aprender com as diversidades e a pensar por si proprio.
Absorption of metals by natural polymers generated from seafood processing wastes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbsorption of metals by natural polymers generated from seafood processing wastesTony C. Yang and Robert R. ZallCite this: Ind. Eng. Chem. Prod. Res. Dev. 1984, 23, 1, 168–172Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/i300013a033https://doi.org/10.1021/i300013a033research-articleACS PublicationsRequest reuse permissionsArticle Views678Altmetric-Citations150LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Flexible Carbon Nanotube Modified Separator for High-Performance Lithium-Sulfur Batteries (2017)

Lithium-sulfur (Li-S) batteries have become promising candidates for electrical energy storage systems due to their high theoretical specific energy density, low cost and environmental friendliness. However, there are some technical obstacles of lithium-sulfur batteries to be addressed, such as the shuttle effect of polysulfides. Here, we introduced organically modified carbon nanotubes (CNTs) as a coating layer for the separator to optimize structure and enhance the performance of the Li-S battery. The results showed that the cell with a CNTs-coated separator exhibited an excellent cycling performance. Compared to the blank separator, the initial discharge capacity and the capacity after 100 cycles for the CNTs-coated separator was increased by 115% and 161%, respectively. Besides, according to the rate capability test cycling from 0.1C to 2C, the battery with a CNTs-coated separator still released a capacity amounting to 90.2% of the initial capacity, when the current density returned back to 0.1C. It is believed that the organically modified CNTs coating effectively suppresses the shuttle effect during the cycling. The employment of a CNTs-coated separator provides a promising approach for high-performance lithium-sulfur batteries.
Magnetic Resonance Image-Guided Transcatheter Closure of Atrial Septal Defects (2003)

These in vivo studies demonstrate that catheter tracking and ASD device closure can be performed under real-time MRI guidance with the use of intravascular antenna guide wires. High-resolution imaging allows accurate determination of ASD size before the intervention, and immediate treatment effects such as changes in right cardiac volumes can also be measured.
Motoneuron Differentiation of Induced Pluripotent Stem Cells from SOD1G93A Mice (2013)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder mainly affecting motor neurons. Mutations in superoxide dismutase-1 (SOD-1) account for about 20% of familial ALS patients. A robust supply of motoneurons carrying the mutated gene would help understand the causes of motoneuron death and develop new therapeutics for the disease. Here, we established induced pluripotent stem (iPS) cell lines from SOD1G93A mice and compared their potency in motoneuron generation with normal iPS cells and mouse embryonic stem cells (E14). Our results showed that iPS cells derived from SOD1G93A mice possessed the similar potency in neuronal differentiation to normal iPS cells and E14 cells and can be efficiently driven to motoneuron-like phenotype. These cells exhibited typical neuronal morphology, expressed key motoneuron markers, including ChAT and HB9, and generated repetitive trains of action potentials. Furthermore, these neurons highly expressed human SOD-1 and exhibited shorter neurites compared to controls. The present study provides evidence that ALS-iPS cells can be used as disease models in high-throughput screening and mechanistic studies due to their ability to efficiently differentiate into specific neuronal subtypes.
Painted Finishes for Special Effects (1993)

Formerly published under the HE series