gebhart/patrepeval huggingface dataset:
Enabling customizable World-Wide Web access to X.500 directory (2002)

This paper deals with the service aspect of X.500 directory services to provide a user-configurable, easy-to-use, and platform-independent directory user interface. To deploy the X.500 white pages service widely, for instance, such an integrated user interface is essential. The availability of powerful World-Wide Web (WWW) clients is already providing this means if they have proper links with the X.500 directory. In this paper, the functionality has been fulfilled by implementing a customizable WWW-X.500 gateway, called Cweb500. It investigates some paramount advantages that the gateway may bring. In our X.500 pilot, the gateway has been utilized satisfactorily with many user-friendly functions, and as an integrated means that combines WWW and X.500 directory services.
A novel fiber alignment shift measurement and correction technique in laser-welded laser module packaging (2005)

A novel measurement and correction technique employing an ultra-high-precision laser displacement meter (LDM) with a 20-nm resolution to probe the postweld-shift (PWS)-induced fiber alignment shifts in laser-welded laser module packaging is presented. The results show that the direction and magnitude of the fiber alignment shifts induced by the PWS in laser-welded laser module packaging can be quantitatively determined by four parameters: the lateral position (r), the position angle (/spl alpha/), the swing angle (/spl theta/), and the tilt angle (/spl psi/). Further studies show that the deformation of the lateral shift and the position angle are the dominant mechanisms that determine the fiber alignment shifts induced by the PWS. This clearly indicates that the PWS can be quantitatively corrected timely by applying a single weld spot on the negative lateral shift and the position angle to compensate for the fiber alignment shifts. In comparison with previous studies of the PWS correction by a qualitatively estimated technique, this LDM technique has significantly provided an important tool for quantitative measurement and correction to the effect of the PWS on the fiber alignment shifts in laser-welded laser module packaging. Therefore, the reliable laser modules with high yield and high performance used in low-cost lightwave transmission systems may be developed and fabricated.
Neighborhood Effects in Wind Farm Performance: A Regression Approach (2017)

The optimization of turbine density in wind farms entails a trade-off between the usage of scarce, expensive land and power losses through turbine wake effects. A quantification and prediction of the wake effect, however, is challenging because of the complex aerodynamic nature of the interdependencies of turbines. In this paper, we propose a parsimonious data driven regression wake model that can be used to predict production losses of existing and potential wind farms. Motivated by simple engineering wake models, the predicting variables are wind speed, the turbine alignment angle, and distance. By utilizing data from two wind farms in Germany, we show that our models can compete with the standard Jensen model in predicting wake effect losses. A scenario analysis reveals that a distance between turbines can be reduced by up to three times the rotor size, without entailing substantial production losses. In contrast, an unfavorable configuration of turbines with respect to the main wind direction can result in production losses that are much higher than in an optimal case.
Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency (2010)

Combined deficiency of coagulation factors V and VIII (F5F8D), an autosomal recessive disorder characterized by coordinate reduction in the plasma levels of factor V (FV) and factor VIII (FVIII), is genetically linked to mutations in the transmembrane lectin ERGIC-53 and the soluble calcium-binding protein MCFD2. Growing evidence indicates that these two proteins form a complex recycling between the endoplasmic reticulum (ER) and the ER-Golgi intermediate compartment and thereby function as a cargo receptor in the early secretory pathway of FV and FVIII. For better understanding of the mechanisms underlying the functional coordination of ERGIC-53 and MCFD2, we herein characterize their interaction by x-ray crystallographic analysis in conjunction with NMR and ultracentrifugation analyses. Inspection of the combined data reveals that ERGIC-53-CRD binds MCFD2 through its molecular surface remote from the sugar-binding site, giving rise to a 11 complex in solution. The interaction is independent of sugar-binding of ERGIC-53 and involves most of the missense mutation sites of MCFD2 so far reported in F5F8D. Comparison with the previously reported uncomplexed structure of each protein indicates that MCFD2 but not ERGIC-53-CRD undergoes significant conformational alterations upon complex formation. Our findings provide a structural basis for the cooperative interplay between ERGIC-53 and MCFD2 in capturing FV and FVIII.
High-power double-clad fiber lasers (1993)

Rare-earth doped, laser-diode-pumped, single-mode, double-clad fiber lasers are studied in detail, experimentally and theoretically, with particular attention to properties of scaling to higher output powers. Gain saturation, spontaneous emission, fiber propagation loss, and the optimum output coupler are considered for oscillator design and laser performance. Thermal properties are investigated, including the thermal fracture limit, the decrease of quantum efficiency with increasing pump power through the temperature dependence of multiphonon decay and ion-ion energy transfer, and thermal lensing. Self-focusing and Raman effects are briefly considered. It is shown that output powers in the tens of watts range are readily feasible with available double-clad fiber lasers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Quinolone binding to DNA is mediated by magnesium ions. (1992)

The binding of plasmid DNA to norfloxacin, a quinolone antibacterial agent, was investigated by fluorescence, electrophoretic DNA unwinding, and affinity chromatography techniques. The amount of quinolone bound to DNA was modulated by the concentration of Mg2+. No interaction was evident in the absence of Mg2+ or in the presence of an excess of Mg2+, whereas maximum binding was observed at a Mg2+ concentration of 1-2 mM. The experimental data can be fitted to the formation of three types of Mg adducts: a binary adduct with norfloxacin and Mg2+, a binary adduct with DNA and Mg2+, and a ternary adduct with quinolone, plasmid, and Mg2+. We propose a model for the ternary complex, in which Mg acts as a bridge between the phosphate groups of the nucleic acid and the carbonyl and carboxyl moieties of norfloxacin. Additional stabilization may arise from stacking interactions between the condensed rings of the drug and DNA bases (especially guanine and adenine), which may account for the preference exhibited by quinolones for single-stranded and purine-rich regions of nucleic acids. Other possible biochemical pathways of drug action are suggested by the observation that norfloxacin binds Mg2+ under conditions that are close to physiological.
RETRACTED ARTICLE: Polymerase Spiral Reaction (PSR): A novel isothermal nucleic acid amplification method (2015)

Abstract In this study, we report a novel isothermal nucleic acid amplification method only requires one pair of primers and one enzyme, termed Polymerase Spiral Reaction (PSR) with high specificity, efficiency and rapidity under isothermal condition. The recombinant plasmid of bla NDM-1 was imported to Escherichia coli BL21 and selected as the microbial target. PSR method employs a Bst DNA polymerase and a pair of primers designed targeting the bla NDM-1 gene sequence. The forward and reverse Tab primer sequences are reverse to each other at their 5’ end (Nr and N), whereas their 3’ end sequences are complementary to their respective target nucleic acid sequences. The PSR method was performed at a constant temperature 61 °C–65 °C, yielding a complicated spiral structure. PSR assay was monitored continuously in a real-time turbidimeter instrument or visually detected with the aid of a fluorescent dye (SYBR Greenı) and could be finished within 1 h with a high accumulation of 10 9 copies of the target and a fine sensitivity of 6 CFU per reaction. Clinical evaluation was also conducted using PSR, showing high specificity of this method. The PSR technique provides a convenient and cost-effective alternative for clinical screening, on-site diagnosis and primary quarantine purposes.
Improvements in Electrical Characteristics of Plasma Enhanced Chemical Vapor Deposition-Tetraethylorthosilicate–SiO<sub>2</sub> by Atomic Hydrogen Passivation via Hot-Wire Technique (2006)

Performing atomic hydrogen passivation via a hot-wire technique even at a quite low temperature of 300 °C on the tetraethoxyorthosilicate (TEOS)–SiO2 films fabricated by plasma enhanced chemical vapor deposition (PECVD) markedly reduced interface trap density (Dit) and fixed oxide charge density (Qox) corresponding to the metal oxide silicon (MOS) interface and oxide bulk property, respectively, i.e., Dit=1×1012 to 6.1×1010 eV-1 cm-2, and Qox=2×1011 to 4.4×1010 cm-2. The breakdown value also considerably shifted from 7.98 to 9.87 MV/cm on the average. Furthermore, the passivation effect of atomic hydrogen originating from the reaction between an Al electrode and a SiO2 interface was extracted to estimate the effective passivation effect of atomic hydrogen dissociated using a hot tungsten filament.
Multi-Beam Optical Disk Drive for High Data Transfer Rate Systems (1992)

A multi-beam optical disk drive, which improves the data transfer rate for magneto-optical disk systems, has been developed. The optical head employs an image rotator for tracing several tracks simultaneously. Four-channel parallel read/write operation has been achieved, and a digital video recording system with a data transfer rate of 22 Mbps has been realized. Real-time data verification at a linear velocity of 33 m/s has been demonstrated. Double track density recording, using a crosstalk canceler, has also been accomplished, and a 5.1×10 -5 bit error rate has been obtained.
Two-Dimensional Crystallization of a Histidine-Tagged Protein on Monolayers of Fluidity-Enhanced Ni<sup>2+</sup>-Chelating Lipids (2002)

Protein two-dimensional (2D) crystallization on lipid monolayers is a powerful method for structure determination. This method has been extended using the specific and strong interaction between histidine residues (of an overexpressed protein) and Ni2+ ions tethered at the headgroup of synthetic lipids. Understanding and then improving the process of adsorption and crystallization of proteins on a lipid monolayer are prerequisites for the production of large and well-ordered crystals of any soluble or membrane His-tagged proteins. These large high-quality arrays are necessary for structural studies at high resolution. We have investigated the steps of adsorption and 2D crystallization of His-HupR using three different lipids: (i) 2-(bis-carboxymethyl-amino)-6-[2-(1,3-di-O-oleyl-glyceroxy)-acetyl-amino] hexanoic acid nickel(II) (Ni-NTA-DOGA), which has been previously used, and two specifically designed Ni2+-chelating lipids, (ii) Ni-NTA-BB, which has two branched (B) alkyl chains and (iii) Ni-NTA-BF, a nonsymmetrical lipid with one branched (B) and one fluorinated (F) chain. These three lipids, when spread at the air−water interface, exhibit various fluidity properties. The adsorption and crystallization process have been monitored in situ and in real time using a variety of complementary techniques such as ellipsometry, shear rigidity measurements of the monolayer, and Brewster angle microscopy, and we have also developed X-ray reflectivity analysis to investigate the evolution of the electron density profile of the lipid−protein monolayer. Electron microscopy observations of the protein−lipid layers were also performed. We have found that the fluidity of the lipid monolayer has a marked influence on the rates of protein adsorption and crystallization of His-HupR. When Ni-NTA-BB is used to form the monolayer, it accelerates the process of protein adsorption and the protein crystallization is three times faster than when Ni-NTA-DOGA is used.
On Optimally Reducing Power Loss in Micro-grids With Power Storage Devices (2014)

Smart micro-grids can produce “renewable” energy and store them in power storage devices. Power loss, however, is a significant problem in power exchange among the micro-grids and between the macro-station and individual micro-grids. To optimally reduce the total power losses in such a power grid system, in this paper, a greedy coalition formation algorithm is proposed, which allows the macro-station to coordinate mutual power exchange among the micro-grids and between each micro-grid and the macro-station. Our algorithm optimizes the total power losses across the entire power grid, including the cost of charging and discharging power storage devices and power losses due to power transfers. The algorithm creates exchange pairs among the micro-grids, giving priority to pairs with higher power loss reduction per exchanged power unit. Through computer-based simulations, we demonstrate that the proposed approach significantly reduces the average power loss compared with the conventional noncooperative method. The simulations also demonstrate that the communications overhead of our proposal (due to negotiations aimed at forming coalitions) does not significantly affect the available communication resource.
A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics (2016)

UMIN000010014 (February, 13, 2013).
A UML-based Graph Transformation Approach for Implementing Domain-Specific Model Transformations (2003)

This paper introduces a UML-based approach for specifying model transformations. The technique is based on graph transformations, where UML class diagrams are used to represent the graph grammars of the input and the output of the transformations, and the transformations are represented as explicitly sequenced elementary rewriting operations. The paper discusses the visual language designed for the representation of transformation programs and the graph transformation execution engine which implements the semantics of the language.
Biotechnological Production of Oligosaccharides — Applications in the Food Industry (2015)

Oligosaccharides are carbohydrates, composed of up to twenty monosaccharides linked by glycosydic bonds, widely used in food and pharmaceutical industries. These compounds can be obtained by extraction from natural sources (milk, vegetables, fruits), and by chemical or biotechnological processes. In the last case, chemical structures and composition of the generated oligosaccharides depend on the type and source of enzymes, and on process conditions, including the initial concentration of substrate. Among the various functions of nondigestible oligosaccharides, one that has attracted attention is its prebiotic potential. The intestinal benefits of prebiotics, such as fructooligosaccharides and inulin as well as their symbiotic association with probiotic bacteria, encompass prevention and treatment of infectious diseases, including viral or bacterial diarrhea, and chronic inflammatory diseases such as ulcerative colitis. Other benefits attributed to prebiotics and probiotics include treatment of inflammatory intestinal and irritable bowel syndrome, prevention of cancer, and modulation of the immune system, mineral absorption and lipid metabolism. Fructooligosaccharides (FOS), galactooligosaccharides (GOS) and chitooligosaccharides (COS) have been widely studied for their prebiotic properties. Moreover, novel oligosaccharides with potential prebiotic activity are currently under investigation. This review will focus mainly on the biotechnological production, health benefits and applications of non-natural oligosaccharides in the food industry.
Determination of mutual diffusion coefficients in water-rich 2-butoxyethanol/water mixtures using the Taylor dispersion technique (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of mutual diffusion coefficients in water-rich 2-butoxyethanol/water mixtures using the Taylor dispersion techniqueRolando C. Castillo, Hector C. Dominguez, and Miguel. CostasCite this: J. Phys. Chem. 1990, 94, 24, 8731–8734Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/j100387a019https://doi.org/10.1021/j100387a019research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Estimation of the Plasma Effect Site Equilibration Rate Constant (ke0) of Propofol in Children Using the Time to Peak Effect (2004)

: Children have a significantly longer tpeak of propofol than adults. The values of ke0 of propofol calculated for children depend on the pharmacokinetic model used and also can only be used with the appropriate set of pharmacokinetic parameters to target effect site in this population.
Prostate specific antigen: biology, biochemistry and available commercial assays (2001)

Prostate specific antigen (PSA) is the marker of choice in the management of prostate cancer. However, PSA is not a simple molecule, existing in the serum in five isoforms and a number of molecular configurations and complexes. The elucidation of the biochemistry of PSA has increased the potential use of the marker in the diagnosis of prostate malignancy. This review summarizes the clinical use of PSA in the management of prostate disease and the assays available in the UK. Assay calibration in relation to the World Health Organization 1st International Standard for Prostate Specific Antigen (90:10) has increased conformity between the various commercial assay kits, and the non-equimolar kits have largely been superseded or withdrawn. Special reference is made to evaluations performed on behalf of the Medical Devices Agency of the Department of Health.
Breeding of Flocculent Industrial Saccharomyces cerevisiae Strains by Introducing the Flocculation Gene FLO1. (1991)

We have cloned a DNA fragment bearing the putative FLO1 gene that controls flocculence in Saccharomyces cerevisiae and showed that the cloned gene is on chromosome I. The flocculation property conferred by the cloned gene in a YCp-type plasmid (single-copy plasmid) was diminished in MATa/MATα. cells, which suggests that the expression of the putative FLO1 gene may be repressed by the MAT information. Introduction of the DNA fragment in a YRp-type plasmid (multi-copy plasmid) into several non-flocculent industrial yeast strains, including bottom- and top-fermenting brewing yeasts, and those for making whisky, wine, sake, and shochu could convert them to flocculent ones.
Severe Lung Lesions Caused by <i>Salmonella</i> Are Prevented by Inhibition of the Contact System (2000)

Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected rats. These pulmonary lesions were prevented when the infected animals were treated with H-D-Pro-Phe-Arg-chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, suggesting that inhibition of contact system activation could be used therapeutically in severe infectious disease.
교육용 로봇 사용경험에 따른 유아의 로봇그림 이미지와 로봇특성 인식 (2010)

본 연구는 만 5세 유아 121명을 대상으로 하여, 교육용 로봇 사용경험 유·무에 따른 로봇그림 이미지와 로봇특성 인식을 알아보고자 하였다. 연구결과, 남아들이 그린 로봇이미지 주제에서 집단 간 유의한 차이가 있었다. 또한 두 집단 유아들 모두 로봇그림의 외형특성을 주로 사람이라고 지각하였으며, 교육용 로봇사용 집단 유아들은 특정 부분만 사람과 같다고 한...
Hierarchical porous silica monoliths: A novel class of microreactors for process intensification in catalysis and adsorption (2016)

Silica monoliths with hierarchical porosity (macro-/mesoporous), prepared by a combination of phase separation (spinodal decomposition) and sol–gel process, have demonstrated remarkable potential as supports for catalysts and adsorbents with improved efficiency and productivity of a number of applications. This is due to perfect homogeneous interconnected porous networks enabling an exceptional mass transfer and a fine control of contact times. Silica monoliths have been functionalized by an important variety of moities and techniques, such as grafting with versatile species (acidic, basic), by alumina coating, immobilization of ionic liquids, in-situ synthesis of nanoparticles of Pd, MOF, and NiMoS 2 , pseudomorphic transformation of the skeleton into MCM-41 or zeolites (SOD, LTA). These functional materials reveal great opportunities for process intensification.
Variables (2005)

The next basic building block we need to look at are variables. Common Lisp supports two kinds of variables: lexical and dynamic.1 These two types correspond roughly to "local" and "global" variables in other languages. However, the correspondence is only approximate. On one hand, some languages' "local" variables are in fact much like Common Lisp's dynamic variables.2 And on the other, some languages' local variables are lexically scoped without providing all the capabilities provided by Common Lisp's lexical variables. In particular, not all languages that provide lexically scoped variables support closures.