gebhart/patrepeval huggingface dataset:
S-100ao protein in serum during acute myocardial infarction (1990)

Concentrations in serum of S100ao protein (alpha alpha form of S-100 protein, which is present at high concentrations in heart muscle) were successively measured by enzyme immunoassay in 21 patients with acute myocardial infarction (AMI) and six with angina pectoris (ANP). Results were compared with measurements of creatine kinase isoenzyme MB (CK-MB) concentrations in the same specimens. Mean S100ao concentrations in sera from 100 healthy adults were 0.12 (SD 0.08) microgram/L. In patients with AMI, S100ao concentrations were 4.74 +/- 5.27 micrograms/L at admission, peaked 8 h after admission (23.5 +/- 27.7 micrograms/L), then decreased gradually. Among nine AMI patients who were admitted within an hour after their attack, eight showed abnormally high concentrations of S100ao in serum (greater than 0.5 microgram/L), whereas only four showed abnormally high CK-MB concentrations (greater than 5 micrograms/L) in sera at the time of admission. Serum S100ao concentrations remained within the normal range in all six patients with ANP; however, serum CK-MB concentrations were increased in two of them. Therefore, serum S100ao is useful not only for detection of AMI but also for differentiating AMI from ANP.
Podcasting In Higher Education: Does It Make A Difference? (2010)

Podcasting is a growing trend in higher education. Major software companies, such as Apple, have dedicated entire websites to podcasting. These podcasts are available to college students to be used as supplemental material for specific coursework at their particular college or university. Unfortunately, due to the new and progressive nature of the technology, empirical studies of the effectiveness of this pedagogical device are rare. This paper presents an empirical study of the effectiveness of podcasting when incorporated as supplemental course material in a university course.
Fully Synthetic Bioengineered Nanomedical Scaffold in Chronic Neuropathic Foot Ulcers. (2018)

The nanomedical scaffold successfully reduced the ulcer depths, stimulated granulation tissue while preventing necrosis, and helped the wounds remain infection free. The outcome of this case series suggests a fully synthetic bioengineered nanomedical scaffold can be used as an alternative to human or animal extracellular matrix in chronic, hard-to-heal neuropathic ulcers.
Endoplasmic Reticulum Exit of a Secretory Glycoprotein in the Absence of Sec24p Family Proteins in Yeast (2005)

Glycoproteins exit the endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae in coat protein complex II (COPII) coated vesicles. The coat consists of the essential proteins Sec23p, Sec24p, Sec13p, Sec31p, Sar1p and Sec16p. Sec24p and its two nonessential homologues Sfb2p and Sfb3p have been suggested to serve in cargo selection. Using temperature-sensitive sec24-1 mutants, we showed previously that a secretory glycoprotein, Hsp150, does not require functional Sec24p for ER exit. Deletion of SFB2, SFB3 or both from wild type or the deletion of SFB2 from sec24-1 cells did not affect Hsp150 transport. SFB3 deletion has been reported to be lethal in sec24-1. However, here we constructed a sec24-1 Deltasfb3 and a sec24-1 Deltasfb2 Deltasfb3 strain and show that Hsp150 was secreted slowly in both. Turning off the SEC24 gene did not inhibit Hsp150 secretion either, and the lack of SEC24 expression in a Deltasfb2 Deltasfb3 deletant still allowed some secretion. The sec24-1 Deltasfb2 Deltasfb3 mutant grew slower than sec24-1. The cells were irregularly shaped, budded from random sites and contained proliferated ER at permissive temperature. At restrictive temperature, the ER formed carmellae-like proliferations. Our data indicate that ER exit may occur in vesicles lacking a full complement of Sec23p/24p and Sec13p/31p, demonstrating diversity in the composition of the COPII coat.
Induction of class II MHC antigen expression in macrophages by <i>Mycoplasma</i> species. (1989)

Several different Mycoplasma species have been shown to act as mitogens for either T or B cells and as stimulators of macrophage tumoricidal activity. In this report, we show that at least five different species of Mycoplasma are capable of inducing class II MHC expression on macrophages. We have observed significant induction of class II MHC surface expression on the myelomonocytic cell line, WEHI-3, as early as 24 h after deliberate infection of cultures, reaching maximal levels by 4 days. This induction was also apparent at the mRNA level as assessed by Northern blot analysis by using A alpha, E alpha, and A beta probes. However, unlike many other previously described MHC-inducing agents, mycoplasmas failed to induce class I MHC expression at either the cell surface or mRNA levels. Kinetic analysis revealed that induction of class II mRNA by mycoplasmas was slower than induction by IFN-gamma requiring 24 h rather than 8 h for significant increases to be noted. Induction by mycoplasmas does not require the presence of live organisms and remains active after heat treatment of 90 degrees C for 30 min. We have also demonstrated that mycoplasma infection of primary bone marrow macrophage cultures leads to the induction of both class I and class II genes and, as in the case of WEHI-3, this induction does not require the presence of live organisms. These data indicate that several Mycoplasma species have the capacity to induce class II MHC expression in WEHI-3 and both class I and class II MHC expression in bone marrow macrophage cultures in the absence of any T cell products.
Radiative decay of plasmons in a metallic nanoshell (2004)

Retarded plasmon eigenmodes in metallic nanoshells are theoretically analyzed, and both plasmon eigenfrequencies and plasmon decay rates are calculated. Spherelike and voidlike plasmon modes are considered and their behavior with geometrical parameters is analyzed. Special attention is given to the problem of radiative decay of different plasmon modes supported by such systems. It is concluded that by varying the shell-layer thickness, the voidlike plasmon decay time can be varied over more than two orders of magnitude throughout the femtosecond range. For shell layers thinner than the characteristic skin depth, the voidlike plasmon modes exhibit subfemtosecond radiative lifetimes and hence they become more radiative than spherelike ones. For shell-layer thickness exceeding the characteristic skin depth, the decay time of the voidlike plasmons becomes of the order of tens of femtoseconds, yielding ultrahigh local-field enhancements. We predict local-field enhancement factors that exceed 60 and 150 in gold and silver nanoshells, respectively. These results are supported by calculations of absorption cross sections of these shells to external light. The results are applied to qualitatively explain strong coupling of plasmons with light in nanocellular metallic films, recently observed in light reflection experiments.
Is Premenstrual Dysphoric Disorder a Distinct Clinical Entity? (1999)

Does the evidence now available support the concept of premenstrual dysphoric disorder (PMDD) as a distinct clinical disorder such that the relative safety and efficacy of potential treatment can be evaluated? In a roundtable discussion of this question, a wealth of information was reviewed by a panel of experts. The key characteristics of PMDD, with clear onset and offset of symptoms closely linked to the menstrual cycle and the prominence of symptoms of anger, irritability, and internal tension, were contrasted with those of known mood and anxiety disorders. PMDD displays a distinct clinical picture that, in the absence of treatment, is remarkably stable from cycle to cycle and over time. Effective treatment of PMDD can be accomplished with serotinergic agents. At least 60% of patients respond to selective serotonin reuptake inhibitors (SSRIs). In comparison with other disorders, PMDD symptoms respond to low doses of SSRIs and to intermittent dosing. Normal functioning of the hypothalamic-pituitary-adrenal (HPA) axis, biologic characteristics generally related to the serotonin system, and a genetic component unrelated to major depression are further features of PMDD that separate it from other affective (mood) disorders. Based on this evidence, the consensus of the group was that PMDD is a distinct clinical entity. Potential treatments for this disorder can now be evaluated on this basis to meet the clear need for effective therapy.
Improving Agility of Cryogenic Air Separation Plants (2007)

Cryogenic air separation plants that produce argon in addition to oxygen and nitrogen use two heat-integrated distillation columns and a side rectifier. The dynamics of the side rectifier are very slow because of three factors: the large number of separation stages, the small amount of argon in the air feed, and the high product purity. Currently, when the plant shuts down, the liquid inventory in the argon column drains into the upper (low-pressure) column. A normal start-up takes about 10 h to achieve argon product purity. The start-up time can be reduced significantly by using storage vessels to collect the liquid that drains from the argon column upon shutdown and reintroducing the liquid during the subsequent start-up. Compared to a 10 h start-up time with no collection points, the time required to achieve argon product purity is reduced to 3.35 h by using 2 collection points and is reduced to 2.23 h by using 6 collection points.
IPng Support for ATM Services (1994)

This white paper describes engineering considerations for IPng as
solicited by RFC 1550 [1]. This memo provides information for the
Internet community. This memo does not specify an Internet standard of
any kind.
High-resolution, live, directional mapping (2020)

Conventional arrhythmia mapping involves building activation maps from numerous catheter placements and sequential acquisitions during a stable rhythm. Multielectrode high-density (HD) catheters have enabled comprehensive and dense maps of electrogram (EGM) amplitude and timing. Despite automated algorithms, activation mapping still involves time annotation, numerous acquisitions, and reannotation—often beyond the ability of an electrophysiologist to verify during mapping. Additionally, conventional activation mapping may involve using all or most of the cardiac chamber to locate the source of arrhythmia.
Long noncoding RNAs and Alzheimer&#39;s disease (2016)

Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer's disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer's disease and focus on some specific lncRNAs that may underlie Alzheimer's disease pathophysiology and therefore could be potential therapeutic targets.
A Novel Fabrication Method of the High-Aspect-Ratio Nano Structure (HAR-Nano Structure) Using a Nano X-Ray Shadow Mask (2006)

This paper describes the novel fabrication method of the high-aspect-ratio nano structure which is impossible by conventional method using a shadow mask and a Deep X-ray Lithography (DXRL). The shadow mask with 1㎛-sized apertures is fabricated on the silicon membrane using a conventional UV-lithography. The size of aperture is reduced to 200㎚ by accumulated low stress silicon nitride using a LPCVD (low pressure chemical vapor deposition) process. The X-ray mask is fabricated by depositing absorber layer (Au, 3㎛) on the back side of nano shadow mask. The thickness of an absorber layer must deposit dozens micrometers to obtain contrast more than 100 for a conventional DXRL process. The thickness of 3㎛-absorber layer can get sufficient contrast using a central beam stop method, blocking high energy X-rays. The nano circle and nano line, 200㎚ in diameter in width, respectively, were demonstrated 700㎚ in height with a negative photoresist of SU-8.
Sealing current and regeneration of copper junctions (1991)

In selected situations, the operating telephone companies apply a sealing (wetting) current of approximately=20 mA to lines containing copper junctions to prevent the contact resistance of the junctions from increasing and/or fluctuating, or to reduce the resistance of an already degraded junction. The effect of a variety of sealing current treatments on the contact resistance of a set of junctions that were aged in an accelerated atmospheric corrosion chamber is examined. A junction configuration in which the wires are only light twisted together was used. Measurements made during and after exposure show that application of 20-mA sealing current approximately limits the contact resistance to less than 21 Omega . Smaller currents allow correspondingly higher contact resistances and fluctuations. Sealing current is shown to be ineffective in preventing the degradation of a junction predisposed to degrade and in regenerating an already degraded junction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Automatic Conversion of MPEG-7 Specification and Data into RDF(S) For Semantic Interoperability in Information Retrieval (2006)

Interoperability between different metadata schemas and data is an important issue for various semantic Web-related applications. The definitions and MPEG-7 data for multimedia content instances can't be used with other metadata standards in a semantically interoperable way. As part of an attempt to build a retrieval system that uses various metadata standards such as MPEG-7 and Dublin Core in a semantic Web environment, we first developed a method for automatically converting the MPEG-7 specification into a RDF schema (RDFS) and MPEG-7 data into RDF data. Our approach is to develop a set of conversion rules for XML Schema definitions into RDF schema definitions, rather than interpreting the semantics of individual components of the MPEG-7 specification
Cherubism: case reports and literature review. (2001)

Two new cherubism cases have been documented and reported. Both were relatively mild clinically, being a Grade I within Motamedi's I to V clinical grading system. Each presented with bilateral posterior mandibular lesions having a multiloculated radiolucent appearance. In each case, detection with eventual diagnosis evolved from a mandibular molar failing to erupt (tooth No. 19). The partial literature review documented the wide spectrum of clinical expression of this disease and the consequent wide variation in its treatment.
A Convenient Preparation of Trifluoroacetonitrile: Application to the Synthesis of a Novel Pyrimidinone Building Block (2004)

Abstract The generation of trifluoroacetonitrile (1) under mild conditions and controlled rates from easily accessible starting materials is described. Dehydration of trifluoroacetamide (2) with trifluoroacetic anhydride in pyridine generates trifluoroacetonitrile at ambient temperatures. As the trifluoroacetonitrile is formed, it distills out of the pyridine reaction mixture and is bubbled into a primary reaction vessel. The rate at which the gas is formed is controlled by the rate of addition of the reactants. The practicality of this method is exemplified via the synthesis of multigram quantities of a novel pyrimidinone building block 3.
Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer (2005)

Overexpression of osteopontin is common in primary NSCLC and may be important in the development and progression of the cancer. Osteopontin levels in the plasma may serve as a biomarker for diagnosing or monitoring patients with NSCLC.
Vesicular-arbuscular Mycorrhizal Peat-based Substrates Enhance Symbiosis Establishment and Growth of Three Micropropagated Species (1993)

Micropropagated plantlets of Gerbera jamesonii H. Bolus ex Hook. F. `Terra Mix', Nephrolepis exaltata (L.) Schott `Florida Ruffles', and Syngonium podophyllum Schott `White Butterfly' were inoculated with two vesicular-arbuscular mycorrhizal (VAM) fungi, Glomus intraradices Schenck and Smith and G. vesiculiferum Gerderman and Trappe. They were potted in three peat-based media to determine the effects of mycorrhizal peat substrate on acclimatization and subsequent growth of micropropagated plantlets under greenhouse conditions. Symbiosis was established between the three ornamental species and VAM fungi within 4 to 8 weeks of culture in the greenhouse, but not during acclimatization. Mortality of Gerbera and Nephrolepis mycorrhizal plantlets was reduced at week 8 compared to the noninoculated control. A peat-based substrate low in P and with good aeration improved VAM fungi spread and efficiency. Mycorrhizal substrates had a long-term benefit of increasing leaf and root dry weight of Gerbera and Nephrolepis . Mycorrhizal Gerbera plants flowered significantly faster than non-mycorrhizal plants.
Luminescence of the Narrow-Band Red Emitting Nitridomagnesosilicate Li<sub>2</sub>(Ca<sub>1–<i>x</i></sub>Sr<sub><i>x</i></sub>)<sub>2</sub>[Mg<sub>2</sub>Si<sub>2</sub>N<sub>6</sub>]:Eu<sup>2+</sup> (<i>x</i> = 0–0.06) (2017)

The nitridomagnesosilicates Li2Ca2[Mg2Si2N6]:Eu2+ and Li2(Ca1.88Sr0.12)[Mg2Si2N6]:Eu2+ show narrow-band red emission at 638 and 634 nm, respectively, with an emission bandwidth of 62 nm (∼1513 cm–1) after excitation in the blue spectral region. Ce3+-doped samples show luminescence in the green spectral range (λem = 540 nm). The compounds were synthesized via solid-state metathesis reaction in Li melts. Refinement of single-crystal X-ray diffraction data revealed that Li2(Ca1.88Sr0.12)[Mg2Si2N6] crystallizes isomorphic to Li2Ca2[Mg2Si2N6]: C2/m [Z = 2, a = 5.5744(2), b = 9.8439(3), c = 6.0170(2) Å, β = 97.2520(10)°, R1 = 0.021, wR2 = 0.047]. Crystal composition was checked by EDS and ICP-OES measurements and luminescence properties are compared to state of the art narrow-band red emitting luminophors. On the basis of its narrow-band emission, application of the novel red luminophor in high CRI white pcLEDs is promising.
Coaching the fundamental skills for an athletic future. (2001)

XIAP may be involved in the development of prostate cancer and play an important role in human prostate carcinogenesis. It is likely to be used as a target of prostate cancer therapy.
Plasma CVD diagnostics by laser spectroscopy. (1987)

Plasma-assisted chemical vapor deposition (CVD) is used to deposit solid films for microelectronic applications. Laser spectroscopic methods should facilitate improved understanding of physical and chemical processes ocurring in CVD which, in turn, should lead to the process control and the novel deposition methods. In this paper, laser diagnostic techniques appropriate to spatially-resolved concentration measurements of the species which are the key to CVD process will be reviewed. The review will mainly encompass the Raman spectroscopy and the laser-induced fluorescence spectroscopy. The specific examples of the investigation of CVD process using these techniques are also described.
Therapeutic potential of endothelin receptor antagonists in diabetes (2000)

Endothelins (ETs) are widely distributed in the body and perform several vascular and non-vascular functions. Experimental evidence indicates that abnormalities of the ET system occur in several organs affected in chronic diabetic complications. Furthermore, ET antagonists were found to prevent structural and functional changes in the target organs of chronic diabetic complications in animal models. Abnormalities of plasma ET levels have also been demonstrated in human diabetes. This review discusses the role of ET in the pathogenesis of chronic diabetic complications. The current experimental evidence suggests that ET antagonism may potentially represent an adjuvant therapeutic tool in the treatment of chronic diabetic complications.
DC fault ride‐through of MMCs for HVDC systems: a review (2016)

As the increasing penetration of modular multilevel converter (MMC)‐based high‐voltage direct current (HVDC) into bulky power transmission systems, the performance of MMC on dealing with DC faults, especially on temporary DC fault in overhead transmission lines, has been becoming more and more significant. A comprehensive overview of MMC on DC fault ride‐through (FRT) capability is discussed. Compared with DC fault blocking capability considered as a passive DC FRT strategy focusing on isolating DC fault from AC sides, the DC FRT capability emphasises remaining converters continuous operating during DC faults to regulate and support the connected AC grids. The principle and prerequisite of MMC on DC FRT are analysed, and then improved MMC topologies with DC fault handling capability are summarised and a corresponding comparison among them is conducted. Finally, applications of MMC with DC FRT capability on HVDC systems and its relative control strategies are presented.
NKR-P1+ cells localize selectively in Rat 9L gliosarcomas but have reduced cytolytic function. (1996)

To better understand immune responses to brain tumors and to develop possible approaches for immunotherapy, we have investigated the leukocyte populations infiltrating the rat 9L gliosarcoma. By immunocytochem-ical analyses of the cells infiltrating the tumor, we observed a substantial number of cells expressing natural killer cell receptor protein 1 (NKR-P1), a marker expressed only on rat lymphocytes capable of non-MHC-restricted cytotoxicity. Previous investigations have determined the existence of three populations of NKR-P1+ lymphocytes in normal rats, including NKR-P1bright/T-cell receptor (TCR)-/CD3-/CD5- (approximately 5-15%), NKR-P1dim-/TCRalphabeta+/CD3+/CD5+ (approximately 1-5%), and NKR-P1dim/TCRgammadelta+/CD3+/CD5+ (approximately 0.5-2%). By one-parameter flow cytometry, it was determined that NKR-P1+ cells constituted 30-60% of the lymphocytes in 9L tumors. Among splenic lymphocytes or peripheral blood leukocytes, NKR-P1bright cells are 1.5-4.5 times more numerous than NKR-P1dim cells. In striking contrast, NKR-p1dim cells were 4-5 times more numerous than NKR-P1bright cells among lymphocytes isolated from 9L tumors. Using quantitative analyses of laser confocal microscopic scans, we determined that NKR-P1dim cells were approximately 4 times as numerous as NKR-P1bright cells in situ, confirming flow cytometric findings. By two-color now cytometric analyses, it was observed that approximately 5-10% of the cells were NKR-p1bright/CD5-/TCR-, a phenotype representative of NK cells. Also, approximately 11-25% of the cells were NKR-P1dim/CD5+/TCR+ cells, corresponding to the T-cell subset with non-MHC-restricted lytic function. In addition, we observed a cell population among 9L-derived lymphocytes with a NKR- p1dim/CD5-/TCR- phenotype (approximately 15-25%). Cells of this phenotype have not been reported previously, and most likely represent NK cells down-modulated for expression of NKR-P1. Alternatively, they might represent cells of unknown origin or cells down-modulated for expression of T-cell markers in the microenvironment of 9L tumors. We also compared the lytic capacity of NKR-P1+ populations derived from normal animals and from 9L gliosarcomas. In these experiments, it was determined that, although cells isolated from 9L tumors had some capacity to lyse tumor target cells, they were clearly less efficient than cells isolated from normal splenocytes. Cumulatively, these data suggest that there is selective localization of cells capable of mediating antitumor responses in 9L, but that tumor-associated factors may down-regulate their function and expression of NKR-P1.