gebhart/patrepeval huggingface dataset:
Evaluation of Cycloserine in the Treatment of Alzheimer's Disease (1995)

This multicenter study evaluated the efficacy and safety of cycloserine and measured its effects on explicit and implicit memory tests in patients with Alzheimer's disease (AD). Four hundred ten patients with AD, aged 50 years or older, were enrolled in this parallel-group, double-blind, placebo-controlled, randomized trial of 5,15, or 50 mg cycloserine or placebo twice daily, and 403 entered the double-blind treatment phase. Two hundred sixty-five patients completed the entire 26-week treatment phase. There were no baseline differences among the four treatment groups. Cognitive Drug Research (CDR) efficacy assessments showed no differences between active treatments and placebo from baseline to study weeks 2, 6, 14, or 26. Patients receiving 15 mg of cycloserine improved significantly on one section of an implicit memory test. No differences among treatments were observed for any other assessment scales evaluated. The incidence and severity of adverse events were similar across treatment groups. Cycloserine was well tolerated but did not demonstrate consistent evidence of efficacy during the course of therapy. Higher doses may be necessary to achieve efficacy in the AD population and do not appear to be precluded by the adverse event profile seen in this study.
Elliptic Curve Cryptography on Smart Cards Without Coprocessors (2000)

Turbulent wall jets have many important engi^^ing applications. Much effort has been spent to investigate the plane turbulent wall jet without external stream (Launder and Rodi 1981,1983,
Stitching error reduction in electron beam lithography with <i>in-situ</i> feedback using self-developing resist (2013)

In electron beam lithography (EBL), a large area pattern is divided into smaller writing fields, which are then stitched together by stage movement to generate the large area pattern. Precise stage movement is essential to minimize the stitching error, and this can be achieved by using laser interferometer-controlled stage. In addition, electron beam deflection must be adjusted to match the stage movement, which is referred to as “writing field alignment.” To expose large area nanostructures, a large writing field must be used; otherwise, the stage movement time would be impractically long. However, writing field alignment accuracy decreases with a larger writing field owing to its low magnification. Here, the authors report that self-developing resist (for which the pattern shows up immediately after exposure, thus eliminating the need for ex-situ development) can provide in-situ feedback for writing field alignment accuracy, which in turn can be used to optimize the alignment. After several iterations using the exposed test pattern in nitrocellulose (self-developing) resist as feedback, the authors reproducibly achieved nearly perfect (<50 nm stitching error) alignment with writing field of 1 mm2 using a Raith EBL system.
Recent advances in synchrotron-based hard x-ray phase contrast imaging (2013)

Ever since the first demonstration of phase contrast imaging (PCI) in the 1930s by Frits Zernike, people have realized the significant advantage of phase contrast over conventional absorption-based imaging in terms of sensitivity to 'transparent' features within specimens. Thus, x-ray phase contrast imaging (XPCI) holds great potential in studies of soft biological tissues, typically containing low Z elements such as C, H, O and N. Particularly when synchrotron hard x-rays are employed, the favourable brightness, energy tunability, monochromatic characteristics and penetration depth have dramatically enhanced the quality and variety of XPCI methods, which permit detection of the phase shift associated with 3D geometry of relatively large samples in a non-destructive manner. In this paper, we review recent advances in several synchrotron-based hard x-ray XPCI methods. Challenges and key factors in methodological development are discussed, and biological and medical applications are presented.
A simple and inexpensive ring oven (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple and inexpensive ring ovenNicolas M. Herrera and Carolyn D. Laux Cite this: J. Chem. Educ. 1973, 50, 11, 756Publication Date (Print):November 1, 1973Publication History Received3 August 2009Published online1 November 1973Published inissue 1 November 1973https://doi.org/10.1021/ed050p756Request reuse permissions Article Views25Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (338 KB) Get e-Alertsclose Get e-Alerts
Large-scale sparse logistic regression (2009)

Logistic Regression is a well-known classification method that has been used widely in many applications of data mining, machine learning, computer vision, and bioinformatics. Sparse logistic regression embeds feature selection in the classification framework using the l1-norm regularization, and is attractive in many applications involving high-dimensional data. In this paper, we propose Lassplore for solving large-scale sparse logistic regression. Specifically, we formulate the problem as the l1-ball constrained smooth convex optimization, and propose to solve the problem using the Nesterov's method, an optimal first-order black-box method for smooth convex optimization. One of the critical issues in the use of the Nesterov's method is the estimation of the step size at each of the optimization iterations. Previous approaches either applies the constant step size which assumes that the Lipschitz gradient is known in advance, or requires a sequence of decreasing step size which leads to slow convergence in practice. In this paper, we propose an adaptive line search scheme which allows to tune the step size adaptively and meanwhile guarantees the optimal convergence rate. Empirical comparisons with several state-of-the-art algorithms demonstrate the efficiency of the proposed Lassplore algorithm for large-scale problems.
Internationalization of the Handle System - A Persistent Global Name Service (1998)

The Handle System is a distributed computer system developed at the Corporation for National Research Initiatives (CNRI). The Handle System provides globally unique, persistent naming and name resolution service over the Internet. This paper gives a brief description of the Handle System, and further discusses internationalization issues involved in designing such a system, specifically the encoding issues of the global namespace to ensure global uniqueness, global readability, and global transcribability. The paper separates the current major practices of character set encoding and their practical use in the Handle System into three categories, namely, the limited character set approach, the use of encoding tags, and the Unicode based encoding. It concludes that, for any global name service to achieve global acceptance, every native alphabet has to be supported. Unicode based UTF-8 encoding is the recommended approach, mainly because it allows recognizable names to be defined in terms...
Third-order nonlinearities of Bi12GeO20 crystal measured by nanosecond radiation (2005)

Negative nonlinear refraction is observed in the photorefractive crystal Bi12GeO20 (BGO) using 7-ns, 532-nm pulsed radiation. The nonlinear refractive index of BGO is measured to be γ=−3.8×10−13cm2W−1 using the z-scan technique. The self-defocusing of nanosecond pulses is attributed to the appearance of free carriers generated from defects, donors, and interband transitions. The nonlinear losses caused by two-photon absorption and self-scattering from dynamic grating are discussed. The nonlinear absorption coefficient is measured to be β=3.8×10−8cmW−1. Moreover, a variation of γ and β with intensity is observed. The comparison with self-focusing and two-photon absorption previously measured using 55-ps pulses is discussed.
Cooperative Relay Service in a Wireless LAN (2007)

As a family of wireless local area network (WLAN) protocols between physical layer and higher layer protocols, IEEE 802.11 has to accommodate the features and requirements of both ends. However, current practice has addressed the problems of these two layers separately and is far from satisfactory. On one end, due to varying channel conditions, WLANs have to provide multiple physical channel rates to support various signal qualities. A low channel rate station not only suffers low throughput, but also significantly degrades the throughput of other stations. On the other end, the power saving mechanism of 802.11 is ineffective in TCP-based communications, in which the wireless network interface (WNI) has to stay awake to quickly acknowledge senders, and hence, the energy is wasted on channel listening during idle awake time. In this paper, considering the needs of both ends, we utilize the idle communication power of the WNI to provide a Cooperative Relay Service (CRS) for WLANs with multiple channel rates. We characterize energy efficiency as energy per bit, instead of energy per second. In CRS, a high channel rate station relays data frames as a proxy between its neighboring stations with low channel rates and the Access Point, improving their throughput and energy efficiency. Different from traditional relaying approaches, CRS compensates a proxy for the energy consumed in data forwarding. The proxy obtains additional channel access time from its clients, leading to the increase of its own throughput without compromising its energy efficiency. Extensive experiments are conducted through a prototype implementation and ns-2 simulations to evaluate our proposed CRS. The experimental results show that CRS achieves significant performance improvements for both low and high channel rate stations
Modular current-mode multiple input minimum circuitfor fuzzy logic controllers (1996)

A new current-mode multiple input minimum circuit designed with 4n+1 transistors for n inputs is proposed. Not only is the problem of accumulated errors solved, but the operation speed is also increased owing to the proposed multiple input minimum circuit having a one stage structure. This circuit had been fabricated using 0.8 µm CMOS technology. Experimental results have verified the function of the circuit and shown the merit of high accuracy and a large dynamic range.
Enhancement of Unequal Error Protection Properties of LDPC Codes (2007)

It has been widely recognized in the literature that irregular low-density parity-check (LDPC) codes exhibit naturally an unequal error protection (UEP) behavior. In this paper, we propose a general method to emphasize and control the UEP properties of LDPC codes. The method is based on a hierarchical optimization of the bit node irregularity profile for each sensitivity class within the codeword by maximizing the average bit node degree while guaranteeing a minimum degree as high as possible. We show that this optimization strategy is efficient, since the codes that we optimize show better UEP capabilities than the codes optimized for the additive white Gaussian noise channel.
Average-Voice-Based Speech Synthesis Using HSMM-Based Speaker Adaptation and Adaptive Training (2007)

In speaker adaptation for speech synthesis, it is desirable to convert both voice characteristics and prosodic features such as F0 and phone duration. For simultaneous adaptation of spectrum, F0 and phone duration within the HMM framework, we need to transform not only the state output distributions corresponding to spectrum and F0 but also the duration distributions corresponding to phone duration. However, it is not straightforward to adapt the state duration because the original HMM does not have explicit duration distributions. Therefore, we utilize the framework of the hidden semi-Markov model (HSMM), which is an HMM having explicit state duration distributions, and we apply an HSMM-based model adaptation algorithm to simultaneously transform both the state output and state duration distributions. Furthermore, we propose an HSMM-based adaptive training algorithm to simultaneously normalize the state output and state duration distributions of the average voice model. We incorporate these techniques into our HSMM-based speech synthesis system, and show their effectiveness from the results of subjective and objective evaluation tests.
Expression of CD4 on human peripheral blood neutrophils (2003)

CD4, the primary receptor for entry of HIV, is known to be expressed on T cells and monocytes/macrophages; healthy natural killer (NK) lymphocytes; in vitro human herpesvirus 6 (HHV6)-infected CD8+, NK, and gammadelta T lymphocytes; CD34+ progenitor cells; and a subset of eosinophils and basophils. We here report the unconventional expression of CD4 at the surface of peripheral blood neutrophils derived from 4 of 51 (7.8%) HIV-1-infected and 3 of 25 (12%) uninfected donors, with similar frequency within the 2 groups. The percentage of CD4+ neutrophils ranged from 39% to 97% of the total neutrophil population. Both surface and cytoplasmic forms of CD4 were present in neutrophils. Quantitative RNA polymerase chain reaction (PCR) revealed that neutrophils contain levels of CD4 mRNA comparable to those of peripheral blood mononuclear cells derived from the same donor. The conformation of CD4 expressed at the surface of neutrophils was similar to that of CD4 expressed on T lymphocytes as determined by the binding of monoclonal antibodies specific for conformational epitopes and the binding of recombinant HIV-1 gp120. Thus, our data provide evidence that neutrophils express endogenous CD4 and bind HIV. Owing to their abundance in peripheral blood, CD4+ neutrophils may influence significantly the biodistribution of HIV delivering it to sites of inflammation or to additional tissue reservoirs.
Electrical properties of semimetallic silicon III and semiconductive silicon IV at ambient pressure (1987)

Microcrystalline samples of BC8 silicon III and hexagonal silicon IV, grown under high pressure in the diamond anvil cell, remain metastable at ambient pressure. Hall-effect and low-temperature resistivity measurements show Si III to be a hole semimetal with p\ensuremath{\approxeq}5\ifmmode\times\else\texttimes\fi{}${10}^{20}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}3}$. Photoconductivity data show that Si IV, like Si I, is an intermediate-gap semiconductor. The observed behavior confirms theoretical predictions on these two new elemental materials.
The K-16 Challenge: The Maryland Case (1999)

Maryland has been engaged in K-16 work since 1996, and has made progress in both alignment of standards and teacher education. The unique partnership among the University System of Maryland, the Maryland State Department of Education, and the Maryland Higher Education Commission has created rich opportunities for collaboration and results. This article describes the partnership relationships, details accomplishments in the areas of mathematics and composition, and offers a case study of Towson University as a work in progress.
High-precision wavelength calibration with laser frequency combs (2007)

Accepted —. Received —; in original form — We describe a possible new technique for precise wavelength calibration of high-resolution astronomical spectrographs using femtosecond-pulsed mode-locked lasers controlled by stable oscillators such as atomic clocks. Such ‘frequency combs ’ provide a series of narrow modes which are uniformly spaced according to the laser’s pulse repetition rate and whose absolute frequencies are known a priori with relative precision better than 10 −12. Simulations of frequency comb spectra show that the photon-limited wavelength calibration precision achievable with existing echelle spectrographs should be∼1 cm s −1 when integrated over a 4000 Å range. Moreover, comb spectra may be used to accurately characterise distortions of the wavelength scale introduced by the spectrograph and detector system. The simulations show that frequency combs with pulse repetition rates of 5–30 GHz are required, given the typical resolving power of existing and possible future echelle spectrographs. Achieving such high repetition rates, together with the desire to produce all comb modes with uniform intensity over the entire optical range, represent the only significant challenges in the design of a practical system. Frequency comb systems may remove wavelength calibration uncertainties from all practical spectroscopic experiments, even those combining data from different telescopes over many decades.
Early Alpha Chain Crosslinking in Human Fibrin Preparations (1988)

Purified fibrinogen preparations were clotted under crosslinking conditions and the evolution of alpha polymers was examined by Western blotting (SDS-PAGE). Monoclonal antibodies that bind to two localized regions within the COOH-terminal portion of the (A) alpha chains of fibrinogen (F-103, A alpha #259-276; F-102, A alpha #540-554) were used for immunodetection. Three crosslinked components (100K, 168K, 210K) that each exhibited coincident F-102 and F-103 immunoreactivities were evident as early as gamma dimer formation under the in vitro conditions employed. Initial events in the alpha chain crosslinking process appeared to include interactions between relatively intact chains and a variety of degraded ones that shared the structure A alpha #1-276, but differed in the extent to which regions between residues approximately #276 and approximately #539 were preserved. Degraded fibrinogen molecules whose A alpha chains all terminated before A alpha #540-554 were isolated from purified fibrinogen preparations by immunoaffinity chromatography on F-102 Sepharose. Immunoblotting data obtained for the crosslinking capacity of these degraded molecules indicated that early crosslinked components (95 K, 205 K) could form even in the absence of intact alpha chain partners. This crosslinking, moreover, could progress to the polymer stage. These findings demonstrate that some early crosslinking activity is localized exclusively within regions NH2-terminal to A alpha approximately #540-554 and suggest that fibrinogen molecules with partially degraded A alpha chains, which are likely to be circulating under many pathophysiologic conditions, can undergo fibrin stabilization through crosslinking despite a loss of at least 70 COOH-terminal A alpha chain residues.
Voltage-Balance Compensator for a Carrier-Based Modulation in the Neutral-Point-Clamped Converter (2008)

This paper presents an optimal voltage-balancing compensator for a specific modulation technique applied to a neutral-point-clamped converter. The technique uses two modulation signals per phase, and it is called double-signal pulsewidth modulation. It completely eliminates low-frequency oscillations in the neutral-point voltage. However, it does not provide natural voltage balancing; therefore, a compensation loop is required. The proposed control generates a feedback compensation signal that correctly modifies the three-phase modulation signals. The optimal compensation signal is calculated by a dynamic limiter according to the intrinsic limitations of the system related to the variability range of the modulation signals. It significantly improves the voltage balancing under all operating conditions of the converter. In addition, this compensation strategy does not increase the switching frequencies of the power devices. The algorithm is tested and verified using both simulation and experimentation.
Two-photon scanning photochemical microscopy: mapping ligand-gated ion channel distributions. (1994)

The locations and densities of ionotropic membrane receptors, which are responsible for receiving synaptic transmission throughout the nervous system, are of prime importance in understanding the function of neural circuits. It is shown that the highly localized liberation of "caged" neurotransmitters by two-photon absorption-mediated photoactivation can be used in conjunction with recording the induced whole-cell current to determine the distribution of ligand-gated ion channels. The technique is potentially sensitive enough to detect individual channels with diffraction-limited spatial resolution. Images of the distribution of nicotinic acetylcholine receptors on cultured BC3H1 cells were obtained using a photoactivatable precursor of the nicotinic agonist carbamoylcholine.
Ancient Greece: From Prehistoric to Hellenistic Times (1996)

In this compact yet comprehensive history of ancient Greece, Thomas R. Martin brings alive Greek civilization from its Stone Age roots to the fourth century B.C. Focusing on the development of the Greek city-state and the society, culture, and architecture of Athens in its Golden Age, Martin integrates political, military, social, and cultural history in a book that will appeal to students and general readers alike. Now in its second edition, this classic work now features new maps and illustrations, a new introduction, and updates throughout. A limpidly written, highly accessible, and comprehensive history of Greece and its civilizations from prehistory through the collapse of Alexander the Great's empire...A highly readable account of ancient Greece, particularly useful as an introductory or review text for the student or the general reader.-Kirkus Reviews A polished and informative work that will be useful for general readers and students.-Daniel Tompkins, Temple University
Clara cell impact in air-side activation of CFTR in small pulmonary airways (2002)

The Clara cells are nonciliated, nonmucous, secretory cells containing characteristic peptidergic granules; they constitute up to 80% of the epithelial cell population of the distal airways. Despite this exposed histotopology and abundance within the terminal airways where fluid secretion is of pivotal importance, the functional role of the Clara cells remained poorly understood. At the transcriptional, translational, and cellular levels, we provide evidence that the Clara cells are well equipped with the bioactive peptide guanylin and proteins of the cGMP-signaling system including guanylate cyclase C, cGMP-dependent protein kinase II, and cystic fibrosis transmembrane conductance regulator (CFTR) together with the two CFTR scaffolding proteins EBP50/NHERF and E3KARP/NHERF-2 that are essential for proper function of CFTR. Guanylin was localized to secretory granules underneath the apical membrane of Clara cells and was, in addition, detected in high concentrations in bronchoalveolar lavage fluid, predicting release of the peptide luminally into the bronchiolar airways. On the other hand, the guanylin-receptor guanylate cyclase C, CFTR, and proteins linked to CFTR activation and function were all confined to the adluminal membrane of Clara cells, implicating an intriguing air-side route of action of guanylin. Whole-cell patch-clamp recordings in the Clara cell line H441 revealed that guanylin activates CFTR Cl(-) conductance via the cGMP but not the cAMP-signaling pathway. Hence, in the critical location of distal airways in situ, the Clara cells may play the outstanding role of CFTR-dependent regulation of epithelial electrolyte/water secretion through a sophisticated paracrine/luminocrine mode of guanylin-induced CFTR activation.