gebhart/patrepeval huggingface dataset:
Molecular and cytological evidence of S-adenosyl-L-homocysteine as an innocuous undermethylating agent in vivo (1995)

Undermethylating agents are frequently used in the study of DNA methylation. However, the drugs of choice to induce experimental DNA undermethylation, 5-azacytidine and 5-aza-2'-deoxycytidine, are known to be cytotoxic. We report on S-adenosyl-L-homocysteine (SAH) as an alternative agent for inducing undermethylation of human DNA in vivo. The molecular and cytological evidence presented in this paper clearly suggests that SAH could be even more efficient than the cytidine analogs; in addition, SAH does not exhibit the secondary toxic effects that cripple the usefulness of cytidine analogs.
Necroscia prasina (Burmeister), a common red-winged phasmid in Borneo (2001)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
PHILOSOPHY OF RELIGION AND THEOLOGY (1971)

PHILOSOPHY OF RELIGION AND THEOLOGY Get access Paths of Faith. By JOHN A. HUTCHISON. New York: McGraw-Hill Book Company. 1969. xv + 656 pages. $7.95. The Religious Experience of Mankind. By NINIAN SMART. New York: Charles Scribner's Sons, 1969. xii + 576 pages. $10.00 hardbound, $4.95 paperbound. In Search of Meaning: Living Religions of the World. By CARL HERMANN VOSS. Cleveland: The World Publishing Company, 1968. 192 pages. $4.50. DAVID G. BRADLEY DAVID G. BRADLEY Duke University Search for other works by this author on: Oxford Academic Google Scholar Journal of the American Academy of Religion, Volume XXXIX, Issue 2, June 1971, Pages 274–276, https://doi.org/10.1093/jaarel/XXXIX.2.274 Published: 01 June 1971
Lensless Fourier-transform ghost imaging with classical incoherent light (2007)

The Fourier-transform ghost imaging of both amplitude-only and pure-phase objects was experimentally observed with classical incoherent light at Fresnel distance by a lensless scheme. The experimental results are in good agreement with the standard Fourier transform of the corresponding objects. This scheme provides a route toward aberration-free diffraction-limited three-dimensional images with classically incoherent thermal light (or neutrons), which have no resolution and depth-of-field limitations of lens-based tomographic systems.
Adobe Dreamweaver CS3 Unleashed (2007)

Adobe® Dreamweaver® CS3 UnleashedZak RuvalcabaThis book is the most comprehensive and independent resource for experienced web developers who want to plan, architect, develop, and deploy state-of-the-art websites, applications, and services.Expert web developer and trainer Zak Ruvalcaba brings together real-world insights and advanced techniques for every facet of contemporary web development, from site management to data-driven applications and multimedia content to security. Ruvalcaba systematically illuminates the major improvements Adobe has brought to Dreamweaver CS3, including its powerful new Spry framework for Ajax development, its innovative CSS browser compatibility checking, and more.You'll learn how to smoothly integrate Dreamweaver CS3 with other key web design and development tools, ranging from Photoshop to Flash to databases. You'll also discover how to use Dreamweaver CS3 to improve team collaboration, automate workflow, streamline content management, and reuse assets more efficiently.Detailed information on how to... Get productive with Dreamweaver CS3 development fast, whether you're new to Dreamweaver or upgrading from previous versions Create more effective, compatible CSS sitesi¾and leverage Dreamweaver CS3's powerful new CSS templates Streamline and automate workflow across your development and content teams Incorporate animation, video, and audio, including Adobe Flash content Make the most of databases and SQL queries in your sites and applications Build dynamic pages and sites that integrate everything from search functionality to user authentication Implement high-performance web services with Adobe Dreamweaver CS3 Use Adobe's new Spry framework, widgets, and effects to quickly build rich XML-based applications Zak Ruvalcaba has been researching, designing, and developing for the Web since 1995. He's built websites and applications for such companies as Gateway, HP, Toshiba, IBM, Intuit, Peachtree, Dell, Qualcomm, Microsoft, and many others. Aside from teaching and holding design lectures on various technologies and tools, including Dreamweaver, ASP.NET, and Flash, for the San Diego Community College District and Palomar Community College, he is the author of the 10 Minute Guide to Dreamweaver 4 from Que Publishing, Build Your Own ASP.NET 2.0 Website Using C# and VB.NET from SitePoint Press, and Beginning Expression Web from Wrox.Register your book at www.samspublishing.com/register for convenient access to updates and example source code from this book.Category:i¾ Web Development/DreamweaverCovers:i¾ Adobe Dreamweaver CS3User Level:i¾ Intermediate-Advanced
A Comparison of diffuse Reflectance Ft-Ir Spectroscopy and Dsc in the Characterization of a Drug-Excipient Interaction (1991)

Differential scanning calorimetry (DSC) and diffuse reflectance Fourier transform infrared spectroscopy (FT-IR) were employed for the characterization of the well-known interaction between aminophylline and lactose. Brown discoloration appears in samples containing 1:5 (w/w) mixtures of aminophylline and lactose following three weeks of storage at 60°C. DSC thermograms can be used to predict that such an interaction will occur, but provide little insight into the nature of the interaction. Using FT-IR, it was possible to show that the discoloration is due to a chemical reaction between ethylenediamine and lactose.
Licensing the Exportation of Nuclear Materials: Responsibility to the Global Environment (1983)

The policy of the United States to supply nuclear power plants and materials to selected foreign nations raises questions concerning environmental concerns, nuclear weaponry problems, and foreign relations considerations. This Note examines the statutory scheme by which Congress has sought to balance these factors and the role of the judiciary in implementing this plan. Specifically, a recent case involving the Nuclear Regulatory Commission's grant of a license for exporting nuclear plant materials to the Philippines is reviewed. The author concludes that this litigation failed to provide adequate guidance for the Commission and for courts in future cases. The author offers suggestions to clarify the indefiniteness that now exists.
Exploiting Multi-Temporal Information for SAR Image Segmentation (2006)

Earth observation is taking more and more importance in our society. Indeed, recent technologies march allows for satellite images to get ground resolution up to less than one meter. Thus, most of satellite image information obtained begins now to be widely used for multiple purposes ranging from cartography and mapping to agricultural management and security applications. Among all the satellite imaging systems, Synthetic Aperture Radar (or SAR) are very interesting for global earth surveillance and monitoring purposes as they can provide data at any time under all weather conditions. However only few work have been done to take advantage of such time robustness properties for retrieving the images main structures. In this study we focused one the particular issue of obtaining an efficient closed region segmentation using multi-temporal SAR image series. To this end, several tools have been developed. In order to remove SAR inherent noise we filtered the image sequences using a multi-temporal anisotropic non-linear diffusion algorithm. Then a new approach of Canny edge detection have been introduced to extract edge features from these vector-valued images. Finally, a region segmentation step has been applied to get closed regions. We demonstrated that for all the methods, exploiting multi-temporal information can improve the results accuracy. Moreover, since some radiometric changes can occur within region due to man intervention or natural diseases we also presented a direct application of region segmentation to retrieve such changes across time series.
Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism. (1998)

This study investigated the role of intracellular free Ca2+ concentration ([Ca2+]i) in apoptosis in MIN6 cells, an insulin secreting cell line, and in mouse islets. Thapsigargin, an inhibitor of sarcoendoplasmic reticulum Ca2+-ATPases (SERCA), caused a time- and concentration-dependent decrease in the viability of MIN6 cells and an increase in DNA fragmentation and nuclear chromatin staining changes characteristic of apoptosis. Two structurally distinct SERCA inhibitors, cyclopiazonic acid and 2,5-di-[t-butyl]-1,4-hydroquinone also caused apoptosis, but agents that increased [Ca2+]i by other mechanisms did not induce apoptosis in MIN6 cells. Carbachol- or ionomycin-releasible intracellular Ca2+ stores were completely depleted in cells treated by SERCA inhibitors, but not by other agents that increase [Ca2+]i. The ability of thapsigargin to induce cell death was not affected by blocking Ca2+ influx or by clamping [Ca2+]i with a cytosolic Ca2+ buffer suggesting that the process did not depend on changes in [Ca2+]i per se. However, application of the lipoxygenase inhibitors 5,8,11-eicosatrienoic acid and nordihydroguaiaretic acid partially prevented MIN6 cell apoptosis, while exposure of cells to the product of lipoxygenase, 12-hydroxy-[5,8,10,14]-eicosatetraenoic acid, caused apoptosis. In contrast, inhibition of cyclooxygenase with indomethacin did not abolish thapsigargin-induced apoptosis in MIN6 cells. Our findings indicate that thapsigargin causes apoptosis in MIN6 cells by depleting intracellular Ca2+ stores and leading to release of intermediate metabolites of arachidonic acid metabolism.
Maximum Relevance and Minimum Redundancy Feature Selection Methods for a Marketing Machine Learning Platform (2019)

In machine learning applications for online product offerings and marketing strategies, there are often hundreds or thousands of features available to build such models. Feature selection is one essential method in such applications for multiple objectives: improving the prediction accuracy by eliminating irrelevant features, accelerating the model training and prediction speed, reducing the monitoring and maintenance workload for feature data pipeline, and providing better model interpretation and diagnosis capability. However, selecting an optimal feature subset from a large feature space is considered as an NP-complete problem. The mRMR (Minimum Redundancy and Maximum Relevance) feature selection framework solves this problem by selecting the relevant features while controlling for the redundancy within the selected features. This paper describes the approach to extend, evaluate, and implement the mRMR feature selection methods for classification problem in a marketing machine learning platform at Uber that automates creation and deployment of targeting and personalization models at scale. This study first extends the existing mRMR methods by introducing a non-linear feature redundancy measure and a model-based feature relevance measure. Then an extensive empirical evaluation is performed for eight different feature selection methods, using one synthetic dataset and three real-world marketing datasets at Uber to cover different use cases. Based on the empirical results, the selected mRMR method is implemented in production for the marketing machine learning platform. A description of the production implementation is provided and an online experiment deployed through the platform is discussed.
Near Real-Time Computer Assisted Surgery for Brain Shift Correction Using Biomechanical Models (2014)

Conventional image-guided neurosurgery relies on preoperative images to provide surgical navigational information and visualization. However, these images are no longer accurate once the skull has been opened and brain shift occurs. To account for changes in the shape of the brain caused by mechanical (e.g., gravity-induced deformations) and physiological effects (e.g., hyperosmotic drug-induced shrinking, or edema-induced swelling), updated images of the brain must be provided to the neuronavigation system in a timely manner for practical use in the operating room. In this paper, a novel preoperative and intraoperative computational processing pipeline for near real-time brain shift correction in the operating room was developed to automate and simplify the processing steps. Preoperatively, a computer model of the patient's brain with a subsequent atlas of potential deformations due to surgery is generated from diagnostic image volumes. In the case of interim gross changes between diagnosis, and surgery when reimaging is necessary, our preoperative pipeline can be generated within one day of surgery. Intraoperatively, sparse data measuring the cortical brain surface is collected using an optically tracked portable laser range scanner. These data are then used to guide an inverse modeling framework whereby full volumetric brain deformations are reconstructed from precomputed atlas solutions to rapidly match intraoperative cortical surface shift measurements. Once complete, the volumetric displacement field is used to update, i.e., deform, preoperative brain images to their intraoperative shifted state. In this paper, five surgical cases were analyzed with respect to the computational pipeline and workflow timing. With respect to postcortical surface data acquisition, the approximate execution time was 4.5 min. The total update process which included positioning the scanner, data acquisition, inverse model processing, and image deforming was ~11-13 min. In addition, easily implemented hardware, software, and workflow processes were identified for improved performance in the near future.
The sequence of cell and matrix changes in atherosclerotic lesions of coronary arteries in the first forty years of life (1990)

We have studied the cell and matrix composition of normal intima and of atherosclerotic lesions in the coronary arteries of 691 subjects less than 40 years old. These arteries were obtained at autopsy and fixed by perfusion with glutaraldehyde under physiological pressure. A defined segment of the left coronary artery, known for its susceptibility to develop advanced lesions, was studied by light and electron microscopy. The initial intimal lesion occurred in infants and consisted in an increase in intimal macrophages and presence of isolated lipid-laden macrophages (foam cells). At puberty, more substantial accumulations of foam cells, accompanied now by lipid droplets in smooth muscle cells and by thinly scattered extracellular lipid (fatty streaks), were present. After puberty, an increasing number of subjects had intermediate lesions and atheroma. Intermediate lesions, characterized by greatly increased extracellular lipid, were the link between fatty streaks and atheroma. Atheroma was characterized by a massive core of extracellular lipid that damaged arterial structure by displacing normal intimal cells and matrix. In the third and more often in the fourth decade, some atheroma contained greatly increased collagen and smooth muscle cells above the lipid core (fibroatheroma). Collagenization and thickening were more marked when evidence of thrombotic deposits was present on the surface or within lesions. Smooth muscle cells were present in the intima of all subjects from birth. In early lesions, lipid in the intima was not associated with an increase in the number of smooth muscle cells. Smooth muscle cells were increased in lesions containing massive extracellular lipid, more so in those having, in addition, a thrombotic component; smooth muscle cells with massive basement membranes occurred in advanced lesions. Macrophages and macrophage foam cells were the cells that increased intimal cellularity at the onset of lesions. Other cell types associated with lesions were lymphocytes, mast cells, and plasma cells, but all of these were less numerous than either smooth muscle cells or macrophages. From birth, intima was always thicker opposite the flow divider wall of a bifurcation (eccentric thickening). When atherosclerotic lesions of any type were present in coronary arteries, the amount of lipid and accompanying cell reactions were greatest in eccentric thickening; intermediate lesions and atheroma were present only in eccentric thickening while fibroatheroma often extended beyond eccentric thickening.
Blood Pressure and NaCl-Sensitive Hypertension Are Influenced by Angiotensin-Converting Enzyme Gene Expression in Transgenic Mice (2002)

ACE plays an important role in the regulation of arterial pressure; however, a linear relationship between ACE expression and arterial pressure has not been demonstrated. The present study employed telemetric monitoring in female transgenic mice to determine the influence of partial and complete deletion of the ACE gene on basal arterial pressure and arterial pressure responses to a high-NaCl diet. On the basal NaCl diet, 24-hour mean arterial pressure was significantly correlated with the number of functional copies of the ACE gene; ie, arterial pressure was lowest in 0-copy (80 +/- 1 mm Hg), intermediate in 1-copy (100 +/- 1 mm Hg), and highest in 2-copy (113 +/- 1 mm Hg) ACE mice. The high-NaCl diet significantly increased mean arterial pressure in 0-copy (99 +/- 1 mm Hg) and 1-copy (108 +/- 1 mm Hg) mice but not in 2-copy mice (114 +/- 1 mm Hg). These results demonstrate a copy-dependent relationship between ACE gene expression and both basal arterial pressure and arterial pressure responses to a high-NaCl diet, suggesting that either partial or complete reduction in the ACE gene can alter arterial pressure.
Shuttle vectors for the archaebacterium Halobacterium volcanii. (1989)

Progress in archaebacterial molecular biology requires tools for genetic analysis. We describe vectors that can be selected and maintained in either Halobacterium volcanii or Escherichia coli. A genetic determinant for resistance to the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor mevinolin was isolated by "shotgun cloning" into a derivative of the endogenous H. volcanii plasmid pHV2, to form pWL2, which transforms sensitive H. volcanii to mevinolin resistance at high frequency. The resistance determinant, portions of pHV2, and an ampicillin- and tetracycline-resistance-conferring pBR322 derivative, pAT153, were ligated together to form the shuttle vectors pWL101 and pWL102. We describe conditions for the use of these vectors and provide preliminary definition of regions essential for drug resistance and for plasmid replication and maintenance.
Influence of Size of Dispersed Silica Particles on Preparation of Thick Silica Films by Using Electrophoretic Sol–Gel Deposition (1996)

Abstract Monodispersed silica particles, which ranged from 0.14 to 0.42 μm in diameter, were prepared by the sol–gel method. These particles were first separated from original sols, and dried, heat-treated, and then re-dispersed in a mixture of ethanol, water, and triethoxy(methyl)silane. Thick silica films without micro-cracks were formed by electrophoretic deposition of the particles on a stainless steel sheet in the re-dispersed sols. The weight of the silica films deposited was increased with increasing particle size at a given applied voltage. On the other hand, density of the films was increased with decreasing particle size. When the particle size was 0.32 μm in diameter, crack-free films of ca. 20 μm in thickness were prepared after heat treatment at 800 °C for 1 h.
The application of machine learning to structural health monitoring (2006)

In broad terms, there are two approaches to damage identification. Model-driven methods establish a high-fidelity physical model of the structure, usually by finite element analysis, and then establish a comparison metric between the model and the measured data from the real structure. If the model is for a system or structure in normal (i.e. undamaged) condition, any departures indicate that the structure has deviated from normal condition and damage is inferred. Data-driven approaches also establish a model, but this is usually a statistical representation of the system, e.g. a probability density function of the normal condition. Departures from normality are then signalled by measured data appearing in regions of very low density. The algorithms that have been developed over the years for data-driven approaches are mainly drawn from the discipline of pattern recognition, or more broadly, machine learning. The object of this paper is to illustrate the utility of the data-driven approach to damage identification by means of a number of case studies.
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. (1990)

The antiproliferative effects and pharmacological interactions of 5-fluorouracil (5-FU) in combination with gamma interferon (IFN-gamma) were determined against the human colon carcinoma H630 cell line in vitro. H630 was 9-fold more resistant to 5-FU, as compared to a relatively sensitive human colon line (C1). IFN-gamma showed modest antiproliferative activity against the H630 line, with a 50% inhibitory concentration of 440 units/ml. Simultaneous treatment of H630 with subinhibitory concentrations of IFN-gamma and 5-FU produced a significant enhancement of the 5-FU-associated growth inhibition. The growth-inhibitory activity of the combination against H630 was prevented by the addition of 20 microM thymidine. Thymidylate synthase (TS) activity was measured by both the 5-fluoro-2'-deoxyuridine-5'-monophosphate binding and catalytic assays, using cytosolic extracts. A 24-h exposure to 1 microM 5-FU in the H630 line resulted in a 3.1-fold increase in the total amount of TS, while in the 5-FU/IFN-gamma-treated cells TS remained unchanged from non-drug-treated control levels. Moreover, we found that free thymidylate synthase in the 5-FU/IFN-gamma-treated cells was significantly decreased, as compared to the cells treated with 5-FU alone. Incorporation of 5-FU into both the RNA and DNA fractions did not change with the addition of IFN-gamma. Accumulation of the fluoropyrimidine metabolites 5-fluoro-2'-deoxyuridine-5'-monophosphate and 5-fluorouridine-5'-triphosphate remained the same for 5-FU alone and the combination treatment. These findings suggest that acute TS induction by 5-FU may provide an important mechanism by which human colon carcinoma cells express decreased sensitivity to 5-FU and that IFN-gamma can reverse the development of resistance to 5-FU in the H630 line by inhibiting the overexpression of TS that results from 5-FU exposure. These studies contribute to a growing understanding of the complex interaction between 5-FU and IFN-gamma.
Grundlagen und Ziele der Arbeit (1992)

Der Begriff Warenwirtschaftssystem wird heute in durchaus unterschiedlichen Zusammenhängen verwendet; eine allgemein anerkannte Definition liegt bisher nicht vor. Ganz allgemein wird darunter die mengen- und wertmäßige Darstellung und Steuerung des Warenflusses in einem Handelsunternehmen verstanden. Wenn dieses Handelsunternehmen einerseits ein kleiner „Tante-Emma-Laden“ und andererseits ein multinationaler Konzern wie Tengelmann sein kann, so sind auch die Anforderungen an die Warenwirtschaftssysteme dieser Unternehmen sehr unterschiedlich. Insbesondere muß das Warenwirtschaftssystem eines filialisierenden Handelsunternehmens wie Tengelmann die Großhandels- und die Einzelhandelsstufe abdecken.