gebhart/patrepeval huggingface dataset:
Cyclosporin-mediated inhibition ofbovine calcineurin by cyclophilins A andB (1992)

ABSTRACT TheCa2+-andcalmodulin-dependentproteinphosphatase calcineurin is inhibited by the immunosuppres-santdrugcyclosporin Ain thepresenceofcyclophilin AorB.Ofthe twoisoforms, cyclophilin Bis morepotent byafactorof O-5 when either the phosphoprotein [32Plcasein or the [32Plphosphoserine [Ser(32P)] form of the 19-residue bovinecardiac cAMP-dependent protein kinase regulatory subunitpeptide RI,, [Ser(32P)'5]RII, is used as substrate. With [Ser(32P'5]RII assubstrate, theconcentrationsofthecyclospo-rinAcyclophilinAandcyclosporinA-cyclophilinBcomplexes,whichcause50%inhibitionofcalcineurin activity, are120and50nM,respectively. Loweringtheconcentrationofcalcineurin80%with [32P]casein as substrate lowered the apparent inhi-bitionconstantforeachcomplexevenfurther; 50%inhibitionof calcineurin was observed at 40 nM for cyclosporin Acyclophilin A, whereas it was < 10 nM for cyclosporinA-cyclophilin B. In all inhibition assays with [32P]casein or [Ser(32P)'5]RI,, the concentration ofcalcineurin required formeasurable phosphatase
The Commercial Development of a Vehicle-mounted Antenna for the L-band Land Mobile Satellite Service (1994)

This paper describes the operation, manufacturing and measured performance of a vehicle-mounted antenna to access satellites in geostationary orbit forming part of the Land-Mobile Satellite Service. The concept was developed by CSIRO and was followed up, over a two-year period, by a collaborative research and development program with the Australian firm, MITEC. This collaboration has resulted in the development to the prototype stage of a high-gain, low-profile, electronically tracking antenna. Antennas designed to this concept could also find application in maritime services but, so far, low-cost methods of achieving this have received very little attention by manufacturers. The paper also describes the nature of the collaboration between CSIRO and MITEC.
The Development of a Comprehensive Risk-Management Program for Prescription Opioid Analgesics: Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS<sup>®</sup>) (2007)

The next step in these studies is to develop regionally specific, risk-minimization-strategies, which is the goal of all risk-management programs. If successful, RADARS will serve as a prototype of such programs for any new drug approved that has measurable abuse potential.
Evaluating the customer perceptions on in-flight service quality (2011)

In the competitive aviation market as a result of the emergence of charter airlines have had to reconsider their in-flight services approach to service provision. Specifically, the in-flight comfort offered based on the service quality perception. However, in-flight service quality is always vague and hard to express in exact number. Therefore, this study applies fuzzy-grey method based to deal with the vagueness and uncertainty. The objective of this study aims to deal with domestic airline in-flight service quality with uncertainty. The study is a key strategic direction of domestic airlines in Taiwan. In general, these considering criteria are self-structured. The results are as follows, (i) the weights of criteria and alternatives are described in linguistic preferences; (ii) using a grey possibility degree to result the ranking order for all alternatives; (iii) an empirical example of in-flight service quality ranking problem in customer perspective.

	 

	Key words: Grey theory, triangular fuzzy numbers, in-flight service quality, linguistic preferences.
Transparent paper: fabrications, properties, and device applications (2013)

Although paper electronics is a compelling concept, the large surface roughness and opaqueness of most paper substrates has hindered its development from a dormant idea to a thriving technology. A recent demonstration of transparent paper with nanoscale surface roughness has revived an interest in using renewable cellulose substrates for electronics and optoelectronics. In this short review, we will first summarize the recent progress of transparent paper electronics through structure engineering. We will also discuss the properties and functionalization of transparent paper, such as surface roughness, printability, thermal stability, etc. Finally, we will summarize the recent achievements on proof-of-concepts of transparent paper, which pave the way for next-generation green electronics fabricated with roll-to-roll printing methods. Advantages of transparent paper over traditional flexible plastic substrates and its challenges will also be discussed.
A slew-rate controlled output driver using pll as compensation circuit (2003)

A slew-rate controlled output driver adopting the delay compensation method has been implemented using 0.18-μm CMOS process for storage device interface. A phase-locked loop (PLL) is used to generate compensation current and constant delay time. The compensation current reduces the slew-rate variation over process, voltage, and temperature variation of the output driver. The constant delay time, which is generated by the replica of the voltage-controlled oscillator in the PLL, reduces the slew-rate variation over load capacitance variation. Such an output driver has 25% less variation at slew rate than that of the conventional output driver. The proposed output driver is able to meet UDMA100 interface that specifies load capacitance ranging from 15 to 40 pF and slew rate from 0.4 to 1.0 V/ns.
Ultra‐high‐molecular‐weight functional siloxane additives in polymers. Effects on processing and properties (2000)

Abstract Two new types of solid siloxane additives for plastics are described which give improved benefits compared to previous silicone additives. Ultra‐high‐molecular‐weight (UHMW) siloxanes are used in the new additives; traditional silicone plastic additives have used much lower molecular‐weight silicones. The siloxane is converted into solid forms, either masterbatch pellets or powders, that are easy to feed, or mix, into plastics during compounding, extrusion, or injection molding. Ultra‐high‐molecular‐weight siloxanes can be compounded into masterbatch pellets at higher siloxane concentrations than previously possible, e. g., up to 50%. They impart improved processing and release, lower coefficient of friction, and broader performance latitude compared to conventional lower‐molecular‐weight silicones. These benefits can be delivered at reduced siloxane levels with increased concentration at the surface interface with a new functionalized UHMW siloxane which provides unique surface segregation characteristics. Ultra‐high‐molecular‐weight siloxanes have been formulated into powders that can also act as processing aids and mechanical property modifiers for highly filled polymers such as fire‐retardant systems. This paper uses polyolefins as a model. However, many of the effects shown in polyolefins have also been seen in other resin systems.
Trichothecenes: From Simple to Complex Mycotoxins (2011)

As the world's population grows, access to a safe food supply will continue to be a global priority. In recent years, the world has experienced an increase in mycotoxin contamination of grains due to climatic and agronomic changes that encourage fungal growth during cultivation. A number of the molds that are plant pathogens produce trichothecene mycotoxins, which are known to cause serious human and animal toxicoses. This review covers the types of trichothecenes, their complexity, and proposed biosynthetic pathways of trichothecenes.
An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial (2021)

Chronic low back pain can be caused by impaired control and degeneration of the multifidus muscles and consequent functional instability of the lumbar spine. Available treatment options have limited effectiveness and prognosis is unfavorable. We conducted an international randomized, double-blind, sham-controlled trial at 26 multidisciplinary centers to determine safety and efficacy of an implantable, restorative neurostimulator designed to restore multifidus neuromuscular control and facilitate relief of symptoms (clinicaltrials.gov identifier: NCT02577354). Two hundred four eligible participants with refractory mechanical (musculoskeletal) chronic LBP and a positive prone instability test indicating impaired multifidus control were implanted and randomized to therapeutic (N = 102) or low-level sham (N = 102) stimulation of the medial branch of the dorsal ramus nerve (multifidus nerve supply) for 30 minutes twice daily. The primary endpoint was the comparison of responder proportions (≥30% relief on the LBP visual analogue scale without analgesics increase) at 120 days. After the primary endpoint assessment, participants in the sham-control group switched to therapeutic stimulation and the combined cohort was assessed through 1 year for long-term outcomes and adverse events. The primary endpoint was inconclusive in terms of treatment superiority (57.1% vs 46.6%; difference: 10.4%; 95% confidence interval, -3.3% to 24.1%, P = 0.138). Prespecified secondary outcomes and analyses were consistent with a modest but clinically meaningful treatment benefit at 120 days. Improvements from baseline, which continued to accrue in all outcome measures after conclusion of the double-blind phase, were clinically important at 1 year. The incidence of serious procedure- or device-related adverse events (3.9%) compared favorably with other neuromodulation therapies for chronic pain.
Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor. (1998)

The calcium-sensing receptor (CaSR) regulates PTH secretion to control the extracellular calcium concentration in adults, but its role in fetal life is unknown. We used CaSR gene knockout mice to investigate the role of the CaSR in regulating fetal calcium metabolism. The normal calcium concentration in fetal blood is raised above the maternal level, an increase that depends upon PTH-related peptide (PTHrP). Heterozygous (+/-) and homozygous (-/-) disruption of the CaSR caused a further increase in the fetal calcium level. This increase was modestly blunted by concomitant disruption of the PTHrP gene and completely reversed by disruption of the PTH/ PTHrP receptor gene. Serum levels of PTH and 1, 25-dihydroxyvitamin D were substantially increased above the normal low fetal levels by disruption of the CaSR. The free deoxypyridinoline level was increased in the amniotic fluid (urine) of CaSR-/- fetuses; this result suggests that fetal bone resorption is increased. Placental calcium transfer was reduced, and renal calcium excretion was increased, by disruption of the CaSR. These studies indicate that the CaSR normally suppresses PTH secretion in the presence of the normal raised (and PTHrP-dependent) fetal calcium level. Disruption of the CaSR causes fetal hyperparathyroidism and hypercalcemia, with additional effects on placental calcium transfer.
The <i>Arabidopsis</i> repressor of light signaling, COP1, is regulated by nuclear exclusion: Mutational analysis by bioluminescence resonance energy transfer (2004)

Bioluminescence resonance energy transfer (BRET) between Renilla luciferase and yellow fluorescent protein has been adapted to serve as a real-time reporter on protein-protein interactions in live plant cells by using the Arabidopsis Constitutive photomorphogenesis 1 (COP1) protein as a model system. COP1 is a repressor of light signal transduction that functions as part of a nuclear E3 ubiquitin ligase. COP1 possesses a leucine-rich nuclear-exclusion signal that resides in a domain implicated in COP1 dimerization. BRET was applied in conjunction with site-directed mutagenesis to explore the respective contributions of the nuclear-exclusion and dimerization motifs to the regulation of COP1 activity in vivo. One specific mutant protein, COP1(L105A), showed increased nuclear accumulation but retained the ability to dimerize, as monitored by BRET, whereas other mutations inhibited both nuclear exclusion and COP1 dimerization. Mutant rescue and overexpression experiments indicated that nuclear exclusion of COP1 protein is a rate-limiting step in light signal transduction.
The Mojave Compiler: Providing Language Primitives for Whole-Process Migration and Speculation for Distributed Applications (2007)

We present an approach for implementing language-level primitives for whole-process migration and speculative execution in a compiler and associated runtime environment. These primitives are exposed to the user through simple language constructs that do not require the user to manage process state explicitly. With migration and speculation we show how the user can quickly add persistent checkpoints to any large-scale distributed application that requires longevity in a faulty environment. We demonstrate the use of migration and speculation primitives for checkpointing in a canonical grid computation application, and analyze the results of this implementation.
Recurrent aphthous stomatitis. Update for the general practitioner. (2003)

Patients presenting with oral mucosal disease can be challenging to diagnose and manage. There are several disorders that can present with similar clinical signs and symptoms, and knowledge of each disease will guide the clinician toward proper management. This article highlights recurrent aphthous stomatitis, a common ulcerative condition encountered in clinical practice. We review the etiology, clinical symptomatology, and topical/systemic therapies that are unique to this disorder and that will help clinicians diagnose and manage this condition.
Zinc-oxide–on–silicon acoustically scanned imager with positive sensitivity and storage capabilities (1975)

The use of remotely launched acoustic surface waves to scan image information on a zinc-oxide–on–silicon monolithic geometry is demonstrated. The dynamic range for the readout can be greatly enhanced by using pulsed bias signals which invert the surface of the n-on-n+ silicon substrate. Images may also be stored in the form of trapped charge replicas in the zinc oxide, and subsequently they may be nondestructively read out using the scanning surface waves.
An Integrated Magnetic Isolated Two-Inductor Boost Converter: Analysis, Design and Experimentation (2005)

This paper presents an integrated magnetic isolated two-inductor boost converter. Patent pending: USPTO/Worldwide filing number 60/444821. All magnetic components are integrated into one magnetic assembly. Two inductor windings are intrinsically coupled to allow input current to increase only when both primary switches are closed. The operation principle, start-up, and protection mechanisms are detailed. A prototype converter has been built. Experimental and simulation results verify the analysis.
Distributed optimization techniques for 4G and beyond (2016)

In today’s and future wireless telecommunication systems, the use of multiple antenna elements\non the transmitter side, and also on the receiver side, provides users a better experience in terms\nof data rate, coverage and energy efficiency. In the fourth generation of such systems, precoding\nemerged as a relevant problem to be optimally solved so that network capacity can be increased\nby exploiting the characteristics of the channel. In this case, transmitters are equipped with few\nantenna elements, say up to eight, which means there are a few tens of precoding matrices,\nassuming a discrete codebook, to be coordinated per transmitter. As the number of antenna\nelements increases at communication nodes, conditions to keep in providing good experience for\nusers become challenging. That’s one of the challenges of the fifth generation. Every transmitter\nmust deal with narrow beams when a massive number of antenna elements is adopted. The hard\npart, regarding the narrowness of beams, is to keep the spatial alignment between transmitter and\nreceiver. Any misalignment makes the received signal quality drop significantly so that users\nno longer experience good coverage. In particular, to provide initial access to unsynchronized\ndevices, transmitters need to find the best beams to send synchronization signals consuming as\nlittle power as possible without any knowledge on unsynchronized devices’ channel states. This\nthesis thus addresses both precoding and beam finding as parameter coordination problems. The\ngoal is to provide methods to solve them in a distributed manner. For this purpose, two types of\niterative algorithms are presented for both. The first and simplest method is the greedy solution\nin which each communication node in the network acts selfishly. The second method and the\nfocus of this work is based on a message-passing algorithm, namely min-sum algorithm, in\nfactor graphs. The precoding problem is modeled as a discrete optimization one whose discrete\nvariables comprise precoding matrix indexes. As for beam finding, a beam sweep procedure is\nadopted and the total consumed power over the network is optimized. Numerical results show\nthat the graph-based solution outperforms the baseline/greedy one in terms of the following\nperformance metrics: a) system capacity for the precoding problem, and b) power consumption\nfor the beam finding one. Although message-passing demands more signaling load and more\niterations to converge compared to baseline method, it usually provides a near-optimal solution\nin a more efficient way than the centralized solution.
Wireless feedback structural control with embedded computing (2006)

In recent years, substantial research has been conducted to advance structural control as a direct means of mitigating the dynamic response of civil structures. In parallel to these efforts, the structural engineering field is currently exploring low-cost wireless sensors for use in structural monitoring systems. To reduce the labor and costs associated with installing extensive lengths of coaxial wires in today's structural control systems, wireless sensors are being considered as building blocks of future systems. In the proposed system, wireless sensors are designed to perform three major tasks in the control system; wireless sensors are responsible for the collection of structural response data, calculation of control forces, and issuing commands to actuators. In this study, a wireless sensor is designed to fulfill these tasks explicitly. However, the demands of the control system, namely the need to respond in real-time, push the limits of current wireless sensor technology. The wireless channel can introduce delay in the communication of data between wireless sensors; in some rare instances, outright data loss can be experienced. Such issues are considered an intricate part of this feasibility study. A prototype Wireless Structural Sensing and Control (WiSSCon) system is presented herein. To validate the performance of this prototype system, shaking table experiments are carried out on a half-scale three story steel structure in which a magnetorheological (MR) damper is installed for real-time control. In comparison to a cable-based control system installed in the same structure, the performance of the WiSSCon system is shown to be effective and reliable.
Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa (1997)

An 1194-nucleotide complementary DNA clone, FM1, encoding a human high-mobility group-1 protein (HMG-1) was isolated from a well-differentiated human gastric-carcinoma cell line complementary DNA library by a differential screening method. FM1 is similar to the published human HMG-1 in mature protein, with only 3 different codons at positions 11, 149, and 190. We analyzed 33 gastric and colorectal adenocarcinomas for expression of the FM1 gene. Northern-blot analysis revealed that all of the cancers expressed FM1 at a higher level than in corresponding non-cancerous mucosa, with 2 transcripts of approximately 1.4 and 2.4 kilobases. The FM1 expression level in the non-cancerous tissues increased with the depth of accompanying cancer invasion. Only 18.2% of well-differentiated cancers showed a higher expression level in corresponding non-cancerous tissues, whereas the expression in corresponding non-cancerous tissues was significantly higher in moderately (60%) and poorly differentiated (83.3%) cancers. In situ hybridization demonstrated the location of FM1 mRNA in well- and poorly differentiated gastric-cancer cells as well as in non-cancerous tissue adjacent to poorly differentiated gastric cancer, but no hybridization was detected in normal epithelial cells adjacent to well-differentiated gastric cancer. These findings may provide new information on HMG-1 mRNA expression in human gastrointestinal cancer and suggest a correlation between FM1 mRNA expression to the differentiation and the stage of human gastrointestinal adenocarcinomas.
Wideband electromagnetic energy harvesting from ambient vibrations (2015)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Dhiman Mallick, Pranay Podder, Saibal Roy; Wideband electromagnetic energy harvesting from ambient vibrations. AIP Conf. Proc. 24 June 2015; 1665 (1): 020001. https://doi.org/10.1063/1.4917572 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
An Introduction to Probability and Statistics Using Basic (2020)

This volume introduces the theoretical ideas in probability and statistics by means of examples. The strengths of the BASIC computer language are exploited to illustrate probabilistic and statistical ideas. Topics described by the Committee on the Under-graduate Program in Mathematics are included.
Zika Virus Seroprevalence, French Polynesia, 2014–2015 (2017)

During 2013-2014, French Polynesia experienced an outbreak of Zika virus infection. Serosurveys conducted at the end of the outbreak and 18 months later showed lower than expected disease prevalence rates (49%) and asymptomatic:symptomatic case ratios (1:1) in the general population but significantly different prevalence rates (66%) and asymptomatic:symptomatic ratios (1:2) in schoolchildren.
A quasioptical resonant-tunneling-diode oscillator operating above 200 GHz (1993)

A quasioptical resonant-tunneling-diode (RTD) oscillator is demonstrated at frequencies above 200 GHz. The oscillator is stabilized by a semiconfocal open cavity. The maximum output power and the linewidth are approximately 50 mu W and 20 kHz, respectively, at a fundamental frequency of 210 GHz. By varying the cavity length, the oscillator frequency can be adjusted over a 0.4-GHz range in a repetitive manner. This behavior is explained by analogy with laser oscillators. The quasioptical RTD oscillator is well suited as a local oscillator for low-power radiometric mixers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nicardipine vs. Saline Injection as Treatment for Peyronie’s Disease: A Prospective, Randomized, Single-Blind Trial (2010)

Our findings indicate that intralesional nicardipine injection is clinically effective as a conservative treatment for PD in the transition period of acute and chronic phase.