gebhart/patrepeval huggingface dataset:
Up-Regulation of the Fibroblast Growth Factor 8 Subfamily in Human Hepatocellular Carcinoma for Cell Survival and Neoangiogenesis Δσ (2010)

FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis. Thus, the FGF8 subfamily supports the development and progression of hepatocellular malignancy.
An Efficient Intracavity Laser Raman Spectrometer (1978)

The design of an optimized intracavity laser Raman spectrometer is described, and representative Raman scattering data are presented. An intracavity laser power of 160 W was attained with an argon ion laser whose normal output power was 1 W.
IMPACT OF CORTICAL INPUT ON SUBTHALAMIC ACTIVITY DURING DEEP BRAIN STIMULATION (2013)

Cortical afferences (e.g., primary motor cortex M1, and supplementary motor area SMA) are believed to play a role in the generation of abnormal oscillatory activity in the subthalamic nucleus (STN) in Parkinson’s disease (PD). Using a computational model, we investigate how cortical inputs impact STN activity during deep brain stimulation (DBS). When cortical input to the STN is constant, high-frequency DBS is able to suppress pathological, low-frequency STN oscillations. On the contrary, when cortical input to the STN is oscillatory, DBS capacity to suppress STN abnormal oscillations is compromised. We propose that DBS induces a functional decoupling between cortex and STN. This functional decoupling may originate from spike cancellation following antidromic activation of cortical afferences.
Profiling of N-Acetylated Protein Termini Provides In-depth Insights into the N-terminal Nature of the Proteome (2010)

N-terminal processing of proteins is a process affecting a large part of the eukaryotic proteome. Although N-terminal processing is an essential process, not many large inventories are available, in particular not for human proteins. Here we show that by using dedicated mass spectrometry-based proteomics techniques it is possible to unravel N-terminal processing in a semicomprehensive way. Our multiprotease approach led to the identification of 1391 acetylated human protein N termini in HEK293 cells and revealed that the role of the penultimate position on the cleavage efficiency by the methionine aminopeptidases is essentially conserved from Escherichia coli to human. Sequence analysis and comparisons of amino acid frequencies in the data sets of experimentally derived N-acetylated peptides from Drosophila melanogaster, Saccharomyces cerevisiae, and Halobacterium salinarum showed an exceptionally higher frequency of alanine residues at the penultimate position of human proteins, whereas the penultimate position in S. cerevisiae and H. salinarum is predominantly a serine. Genome-wide comparisons revealed that this effect is not related to protein N-terminal processing but can be traced back to characteristics of the genome.
REVIEWS (1957)

Journal Article REVIEWS Get access The Latin Charters of the Anglo-Saxon Period. By F. M. STENTON. Pp. viii+103. Oxford: Clarendon Press, 1955. 10s. 6d. net. F. E. HARMER F. E. HARMER Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume VIII, Issue 30, 1957, Pages 176–177, https://doi.org/10.1093/res/VIII.30.176 Published: 01 April 1957
Containerization and the PaaS Cloud (2015)

Containerization is widely discussed as a lightweight virtualization solution. Apart from exhibiting benefits over traditional virtual machines in the cloud, containers are especially relevant for platform-as-a-service (PaaS) clouds to manage and orchestrate applications through containers as an application packaging mechanism. This article discusses the requirements that arise from having to facilitate applications through distributed multicloud platforms.
A comparison of human and model observers in multislice LROC studies (2005)

Model and human observers have been compared in a series of localization receiver operating characteristic (LROC) studies involving single-slice and multislice image displays. The task was detection of Ga-avid lymphomas within single photon emission computed tomography (SPECT)-reconstructed transverse slices of a mathematical phantom, and the studies involved four reconstruction strategies: the filtered-backprojection (FBP) and ordered-subset expectation-maximization (OSEM) algorithms with two- and three-dimensional postreconstruction filtering. The human-observer data was drawn from studies performed by Wells et al. (2000), while multiclass versions of the nonprewhitening (NPW), channelized nonprewhitening (CNPW), and channelized Hotelling (CH) model observers, each capable of performing the tumor search task, were applied. The channelized observers were evaluated with multiple square-channel models and both with and without internal noise. For the multislice studies, two different capacities for integrating the slice information were also tested. The CH observer gave good quantitative agreement with the human data from both image-display studies when the internal-noise model was used. The CNPW observer performed similarly with the iterative strategies. Wells et al. had shown that human observers are imperfect integrators of multislice information, and this is characterized as increased internal noise with the model observers.
TOPICAL FIBRONECTIN THERAPY IN PERSISTENT CORNEAL ULCERATION (1987)

Fifteen patients with 20 episodes of persistent corneal ulceration, resistant to conventional therapy, were treated with topical autologous fibronectin. Thirteen corneal ulcers (eight patients) developed following penetrating keratoplasty, three patients had mucous membrane pemphigoid, two patients had herpetic keratitis and one each had Sjögren's syndrome and a trophic corneal ulcer. A standard protocol for fibronectin administration was followed. This therapy healed 16 of the 20 ulcers after a mean duration of treatment of 2.3 months. Corneal ulceration associated with mucous membrane pemphigoid failed to respond to fibronectin. Corneal ulcers which recurred after cessation of fibronectin responded to reintroduction of this therapy. Topical fibronectin is an effective therapy for refractory corneal ulceration and is free of major side effects.
High-efficiency fluorescent white organic light-emitting diodes using double hole-transporting-layers (2008)

High-efficiency fluorescent white organic light-emitting diodes (OLED) were fabricated by using double holetransporting- layers (HTLs), poly(3,4-ethylene- dioxythiophene)-poly-(styrenesulfonate) (PEDOT) and N,N'-bis-(1- naphthyl)-N,N'-diphenyl-1,10-biphenyl-4-4'-diamine (NPB). The diodes were composed of a single emissive-layer (EML), with 0.5 wt% red 4-(dicyanomethylene)-2-tbutyl-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran doped in a mixed-host of 25% trans-1,2-bis(6-(N,N-di-p-tolylamino)-Naphthalene-2-yl)ethene and 75% 1-butyl-9,10-naphthaleneanthracene. The device structure comprised a 125 nm anode layer of indium tin oxide, a 25 nm first HTL of PEDOT, a 0 to 10 nm second HTL of NPB, a 30 nm EML, a 40 nm electron-transporting-layer of 2,2',2"-(1,3,5-benzenetriyl)-tris(1- phenyl-1-H-benzimidazole), a 1 nm electron-injection-layer of lithium fluoride and a 150 nm cathode layer of aluminum. With the addition of a 7.5 nm second HTL (NPB), the resultant power-efficiency at 100 cd/m<sup>2</sup>, for example, was increased from 11.9 to 18.9 lm/W, an improvement of 59%. The improvement was even more marked at 1,000 cd/m<sup>2</sup>, i.e. that the power-efficiency was increased from 9.1 to 16.5 lm/W, an improvement of 81%. The marked efficiency improvement may be attributed to a better balance of carrier-injection in the desired emissive zone since the addition of the NPB layer in between the first HTL and the EML may have effectively reduced the injection of excessive holes into the EML due to the relatively high energy-barrier to hole, which was 0.5 eV, at the interface of the two HTLs. The resultant hole-blocking function was plausibly more effective at higher voltage so that comparatively much less holes would be injected into the EML, leading to a much better balanced carrier-injection and consequently a higher efficiency-improvement at the higher brightness.
<title>Telecentric vision system for broach verification</title> (1999)

A common machine vision task is to verify that a product has been properly fabricated or assembled. In this paper, a vision system is described for confirming that a type of gear has been processed properly. The main problem in this application is the relatively large depth of the gear which result in a more complex image than the desired silhouette of the pat. The resulting image shows a portion of the inner wall due to the varying magnification because some points on this wall are closer to the lines than others. Employing telecentric optics, however, greatly simplifies the problem since only light rays parallel to the optical axis create the image so that a good silhouette of the part is obtained. Gear teeth can then be isolated using mathematical morphology techniques to verify that the part has been properly broached.
Robust Truck Cabin Layout Optimization Using Advanced Driver Variance Models (2005)

One important source of variance in the performance and success of products designed for use by people is the people themselves. In many cases, the acceptability of the design is affected more by the variance in the human users than by the variance attributable to the hardware from which the product is constructed. Consequently, optimization of products used by people may benefit from consideration of human variance through robust design methodologies. We propose that design under uncertainty methodologies can be utilized to generate designs that are robust to variance among users, including differences in age, physical size, strength, and cognitive capability. Including human variance as an inherent part of the product optimization process will improve the overall performance of the product (be it comfort, maintainability, cognitive performance, or other metrics of interest) and could lead to products that are more accessible to broader populations, less expensive, and safer. A case study involving the layout of the interior of a heavy truck cab is presented, focusing on simultaneous placement of the seat and steering wheel adjustment ranges. Tradeoffs between adjustability/cost, driver accommodation, and safety are explored under this paradigm.
Bronquiolitis obliterante con neumonía organizada inducida por rapamicina en un paciente trasplantado hepático (2009)

Bronquiolitis obliterante con neumonía organizada inducida por rapamicina en un paciente trasplantado hepático
New phosphorescent platinum(ii) Schiff base complexes for PHOLED applications (2012)

Some new symmetric and asymmetric platinum(II) Schiff base complexes with bulky substituents such as tert-butyl and triphenylamino groups have been synthesized which effectively reduced the aggregation or excimer formation. Using selected complexes as phosphorescent emitting materials, yellow light-emitting devices were fabricated with improved efficiency compared with the previously reported analogues. In addition, the phosphorescent white organic light-emitting device (WOLED) was fabricated using a single emissive layer composed of yellow- and blue-emitting materials.
Biocompatibility of Hemoglobin Solutions. I. Reactions of Vascular Endothelial Cells to Pure and Impure Hemoglobins (1989)

Hemoglobin (Hb) solutions can cause vasoconstriction and activation of intravascular coagulation. Because the endothelium plays a major role in the regulation of vascular tone and hemostasis, a study was conducted of human umbilical vein endothelial cells (EC) incubated with various Hbs. Cell injury was evaluated by electron microscopy and the release of lactic dehydrogenase, H2O2, and procoagulant "tissue factor." Cell reaction was assessed by the measurement of 6-keto-prostaglandin F (PGF)1 alpha (metabolite of prostacyclin) and thromboxane B2 (metabolite of thromboxane A2). Incubation with unmodified bovine hemoglobin for 24 h caused no cell injury and a reaction characterized by 48.4 +/- 8.2% increase in 6-keto-PGF1 alpha production, accompanied by 40.2 +/- 9.4% reduction in thromboxane (Tx)B2 (compared with a control group of EC incubated with saline solution). Incubation with a nonpure Hb solution (Hb plus red blood cell membrane aminophospholipids; a-PLs) caused cell injury with significant release of tissue factor, plus a reaction characterized by 97.5 +/- 12.5% increase in TxB2 production accompanied by 25.3 +/- 3% reduction in 6-keto-PGF1 alpha. A second nonpure Hb [Hb plus bacterial environmental endotoxin (E)] caused cell injury, the release of tissue factor, and increased production of both prostaglandins, with greater release of TxB2 (197 +/- 17%) than of 6-keto-PGF1 alpha (112 +/- 8.3%). These data indicate that the endothelium reacts differently to pure and nonpure hemoglobins. The biocompatibility of Hb solutions, with regard to vasoconstriction and activation of intravascular coagulation, depends on the absence of stromal a-PLs and bacterial E.
Surface hydrogen release during the growth of <i>a</i>‐Si:H by reactive magnetron sputtering (1990)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. R. Abelson, J. R. Doyle, L. Mandrell, A. M. Myers, N. Maley; Surface hydrogen release during the growth of a‐Si:H by reactive magnetron sputtering. J. Vac. Sci. Technol. A 1 May 1990; 8 (3): 1364–1368. https://doi.org/10.1116/1.576883 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Decarboxylation Reaction of Oxalacetic Acid by Metal Chelates (1971)

Decarboxylation of oxalacetic acid (OAA) by metal chelates was examined, using copper (II) as a metal and seven kinds of ligand, which forms N, N-coordinated five membered ring chelate, used were 6, 6'-dimethyl-α, α'-dipyridyl, 4, 4'-dimethyl-α, α'-dipyridyl, α, α'-dipyridyl, 5-nitro-ο-phenanthroline, ο-phenanthroline, 4, 7-dimethyl-ο-phenanthroline, and ethylenediamine. When the concentration ratio of dipyridyl to copper (II) was varied, 1 : 1 ratio of copper to dipyridyl effected the fastest decarboxylation rate of OAA, and the rate was faster than that by copper (II) ion alone. Effect of each ligand on the reaction rate was examined and the reaction rate fell in the order of α, α'-dipyridyl, ο-phenanthroline, and ethylenediamine ; 5-nitro-ο-phenanthroline, ο-phenanthroline, and 4, 7-dimethyl-ο-phenanthroline ; α, α'-dipyridyl, 6, 6'-dimethyl-α, α'-dipyridyl, and 4, 4'-dimethyl-α, α'-dipyridyl. When the acetate buffer concentration was 0.1M, the reaction rate was faster, the smaller the pKa, and greater the catalytic effect. When the buffer concentration was 1.0M, the above order did not hold. It was also revealed that steric effect of the ligand affected this reaction. The intermediate formed in this decarboxylation reaction was examined by the measurement of ultraviolet and infrared spectra, and by isolation of this intermediate, and formation of a mixed chelate compound of OAA, copper, and ligand was confirmed.
Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice (2013)

Overexpression of the tyrosine kinase receptor, ErbB2/HER2/Neu, occurs in 25-30% of invasive breast cancer (BC) with poor patient prognosis. Due to confounding factors, inconsistencies still remain regarding the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on BC. We therefore evaluated whether fat-1 transgenic mice, endogenously synthesizing n-3 PUFAs from n-6 PUFAs, were protected against BC development, and we then aimed to study in vivo a mechanism potentially involved in such protection. E0771 BC cells were implanted into fat-1 and wild-type (WT) mice. After tumorigenesis examination, we analyzed the expression of proteins involved in the HER2 signaling pathway and lipidomic analyses were performed in tumor tissues and plasma. Our results showed that tumors totally disappeared by day 15 in fat-1 mice but continued to grow in WT mice. This prevention can be related in part to significant repression of the HER2/β-catenin signaling pathway and formation of significant levels of n-3 PUFA-derived bioactive mediators (particularly 15-hydroxyeicosapentaenoic acid, 17-hydroxydocosahexaenoic acid, and prostaglandin E3) in the tumors of fat-1 mice compared with WT mice. All together these data demonstrate an anti-BC effect of n-3 PUFAs through, at least in part, HER2 signaling pathway downregulation, and highlight the importance of gene-diet interactions in BC.
2-Phenylthioallyl alcohols and their use in the synthesis of 1,4-diketones and cyclopentenones (1976)

1-Phenylthiovinyl-lithium adds to n-hexanal to give the allylic alcohol (II) that undergoes the Carroll and Claisen rearrangement with formation of the carbonyl compounds (IV) which can be converted into dihydrojasmone (VIa) and 2-n-pentylcyclopent-2-enone (VIb) by hydrolysis and cyclisation.
ADAM7, A Member of the ADAM (A Disintegrin And Metalloprotease) Gene Family Is Specifically Expressed in the Mouse Anterior Pituitary and Epididymis<sup>1</sup> (1997)

The maturation of spermatozoa in the epididymis is a complex process that requires the active involvement of the epididymal epithelium. The primary focus toward elucidating the role of the epididymis in the maturation process has been the study of epididymal secretory proteins and their interaction with spermatozoa. To date there is a paucity of information regarding epididymal epithelial cell surface proteins, which may also play important roles in epididymal function. Through a subtractive hybridization approach to identify genes specifically expressed in the caput epididymidis, the mouse homologue of a member of the ADAM (a disintegrin and metalloprotease) family of proteins was identified. This rapidly growing gene family encodes cell surface proteins that possess putative adhesion and protease domains. Northern blot analyses demonstrated that the mouse ADAM gene, termed ADAM7, is expressed in the caput region of the epididymis and in the anterior pituitary gonadotropes with no detectable expression in the twenty-six other tissues examined. Furthermore, in situ hybridization experiments revealed that the ADAM7 messenger RNA (mRNA) exhibited an apical localization within the proximal caput epididymal epithelium that may correlate with an unusual sparsely granulated endoplasmic reticulum uniquely present in the proximal region of the epididymidis and to which no known function has been ascribed. Hormonal, surgical, and genetic strategies demonstrated that ADAM7 gene expression requires, in a region-dependent manner, androgens as well as testicular factors for expression. Interestingly, the apical localization of ADAM7 mRNA is dependent upon an intact testis, because in situ hybridization analyses of the proximal caput epididymidis from a testosterone maintained castrate mouse did not show the apical localization of ADAM7 mRNA. Finally, chromosomal mapping demonstrated that the ADAM7 gene maps to the central region of mouse Chromosome 14, approximately 4-5 cM distal from the fertilin beta locus, which encodes another reproductive-specific ADAM protein.
Observable-preserving control of quantum dynamics over a family of related systems (2005)

Quantum control aims at the manipulation of atomic- and molecular-scale dynamics phenomena. An important objective in this regard is the understanding of dynamical control within a family of related quantum systems. To explore this issue, diffeomorphic changes in the system Hamiltonian $\mathcal{H}(s,t)$ are introduced by scanning over a homotopy parameter $s$ and then monitoring the control field response needed to maintain the value of a specified target observable. This operation is implemented through a procedure referred to as diffeomorphic modulation under observable-response-preserving homotopy (D-MORPH). The governing D-MORPH differential equation determining the control laser field $E(s,t)$ is shown to explicitly allow for innumerable solutions, with each characterized by the choice of an arbitrary function $f(s,t)$ of $s$ and time $t$. The presence of $f(s,t)$ in the D-MORPH differential equation makes clear the origin of multiple control fields that produce the same observable objective. A stable algorithm is presented for practical execution of D-MORPH with the only criterion that the Hamiltonian $\mathcal{H}(s,t)$ permit reaching the objective over the full domain of $s$ being sampled. Both analytic and numerical examples are presented to illustrate the D-MORPH concept.
Beneficial Effects of Dietary Intervention on Serum Lipid and Apolipoprotein Levels in Obese Children (1992)

Effects of weight reduction on serum levels of lipids and apolipoproteins were measured in 13 obese children (seven girls, six boys). Mean weight loss of 8.4% of the initial body weight was achieved after 4 weeks of energy intake restriction and exercise. Serum total cholesterol (5.46 +/- 1.01 mmol/L) and triglyceride (2.08 +/- 0.52 mmol/L) levels were significantly high compared with control values before treatment and were significantly reduced to 4.32 +/- 0.75 and 1.31 +/- 0.42 mmol/L, respectively, after treatment. Serum high-density lipoprotein cholesterol level (1.03 +/- 0.23 mmol/L) was significantly low and unchanged after treatment (0.94 +/- 0.25 mmol/L). Serum apolipoprotein A-I level (0.039 +/- 0.009 mmol/L or 111 +/- 0.26 g/L) was normal before treatment and significantly reduced, to 0.032 +/- 0.007 mmol/L or 0.92 +/- 0.19 g/L, after weight reduction. Serum apolipoprotein B level (0.00019 +/- 0.00007 mmol/L or 1.07 +/- 0.21 g/L) was significantly high before treatment and decreased to the normal range after treatment (0.00014 +/- 0.0009 mmol/L or 0.76 +/- 0.24 g/L). The ratio of apolipoprotein B to apolipoprotein A-I (1.09 +/- 0.29) was significantly high on admission and decreased significantly to 0.64 +/- 0.12 after treatment. Serum apolipoprotein E level (0.0014 +/- 0.0006 mmol/L or 0.05 +/- 0.02 g/L) was normal and decreased to 0.0008 +/- 0.0002 mmol/L or 0.03 +/- 0.01 g/L after treatment. In conclusion, weight reduction achieved by energy intake restriction and exercise had beneficial effects on serum lipid and apolipoprotein concentrations for the prevention of future atherosclerosis.
Detonation Synthesis of TiO<sub>2</sub> Nanoparticles in Gas Phase (2008)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.