gebhart/patrepeval huggingface dataset:
Current clinical characteristics and economic impact of subacute stent thrombosis. (2002)

Subacute stent thrombosis (SAT), while uncommon, continues to produce serious clinical consequences, including major myocardial infarction (MI) in 60 70% of cases, and short-term mortality rates of 20% or higher. A number of procedural and patient factors have been shown to predict the occurrence of SAT, including longer stent length, smaller minimum luminal diameter, persistent dissection, multivessel intervention, and possibly acute coronary syndrome (ACS) presentation. Despite substantial knowledge about the clinical and technical aspects of SAT, the economic impact of these events has not been previously reported. Methods. We retrospectively reviewed 26 cases of SAT that occurred at our institution from 1998-2000. Baseline clinical and procedural data, as well as clinical outcomes for the initial hospital admissions required to treat SAT, were obtained by record review. Direct health care costs for these admissions were calculated based on hospital billing data and measured resource utilization for catheterization laboratory procedures. Results. Most cases of SAT occurred in high-risk circumstances, including ACSs, multi-stent interventions, and treatment of 3.0 mm or smaller vessels. Most patients suffered significant MIs and were treated with repeat percutaneous coronary intervention. The median time to SAT was 3.5 days, with 58% of events occurring on an outpatient basis. Median total hospital costs were $11,100 per patient, with more than half of the costs generated by the catheterization laboratory and pharmacy. Conclusions. Despite its low overall frequency, the clinical and economic costs of SAT are substantial. Specific strategies at preventing its occurrence are warranted, particularly in high-risk situations.
Circadian clock mutants of Drosophila melanogaster (1972)

Three mutants of Drosophila melanogaster have been isolated in which the free-running period of the circadian eclosion rhythm and the adult locomotor activity rhythm is affected. One mutant is arrhythmic, another has a short period of 19 hours, and the third has a long period of 28 hours. The mutants retain their phenotypes over the temperature range 18° to 25° C. All three mutants map near the tip of the X chromosome (distal to the centromere). By deficiency mapping, the short-period mutation has been localized to the 3B1-2 region. Complementation tests show that all three mutations affect the same functional gene. Analysis of activity rhythms of individual mosaic flies indicates that the site of action of the short-period mutation is probably located in the head of the fly. A few activity patterns of split-head and mixed-head mosaics appear to possess both mutant and heterozygous components, suggesting that the fly head may contain
two complete clocks capable of maintaining their periodicities independently. The short-period mutation affects both the duration of the light-insensitive part of the oscillation and the degree to which the clock can be reset during the light-sensitive part of the oscillation. Both the short-period and long-period mutant eclosion rhythms can be entrained to a period of 24 hours by a 12:12 light-dark cycle having a light intensity at least two orders of magnitude greater than that required to entrain the normal rhythm. The arrhythmic mutant does not entrain under these conditions. In the presence of a temperature cycle, however, the arrhythmic mutant does entrain, but its rhythm damps out when the temperature cycle is removed. Evidence is presented that Pittendrigh's two-oscillator model for the clock in D. pseudoobscura applies to D. melanogaster as well. The three clock mutations primarily affect the light- sensitive driving oscillator. The arrhythmic mutation appears to have eliminated the driving oscillator while leaving the temperature-sensitive driven oscillator relatively intact.
Delayed Manipulation after Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture (2014)

Therapeutic, Level II.
Multi-objective Optimization of Cross-Layer Configuration for Cognitive Wireless Network (2009)

Resources optimization of cross-layer is a typical multi-objective optimization problem. In this paper, an adaptive clone and neighbor selection algorithm is proposed to resolve optimization resources allocation in cognitive radio networks (CRNs). The algorithm uses the adaptive cloning operator, neighborhood search operator to improve the performance of algorithm. Simulation comparisons for typical test functions show that the proposed algorithm can effectively solve the multi-objective optimization. We use the proposed algorithm to optimize two goals of used bandwidth and power consumption for cognitive networks. And then the fuzzy algorithm is used to select the best configuration parameters of bandwidth and power from a set of optimal solutions. Simulation results show that the algorithm can effectively address the spectrum allocation and power control in cognitive radio networks.
Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage. (1987)

In order to determine the contribution of thymidine (dThd) salvage to intrinsic resistance to antimetabolites (5-fluoropyrimidines, antifolates) in the human colon adenocarcinoma xenograft, H X GC3, a subline deficient in thymidine kinase has been developed. A cell line (GC3/M) was established in continuous culture that demonstrated a karyotype identical to that of the stem line of H X GC3 (46,X, - Y + 12). After inoculation of GC3/M cells into immune-deprived CBA/CaJ mice, the H X GC3/M xenografts retained histological, histochemical, and growth characteristics of the H X GC3 xenograft. To develop a line deficient in dThd salvage, GC3/M cells were selected with BrdUrd (100 micrograms/ml). Three clones characterized were unable to proliferate in HAT medium, and were deficient (less than 10% control) in the cytosolic form of thymidine kinase. Activities of dThd phosphorylase and dTMP synthase were unchanged from parental GC3/M cells. Of the three clones inoculated into mice, GC3/M TK- 100 C3 was tumorigenic, the xenografts demonstrating histological and growth characteristics similar to H X GC3. The in vivo activity of the cytosolic form of dThd kinase was 3.5% of that in H X GC3 xenografts. Incorporation in vivo of [methyl-3H]dThd into acid insoluble material was 14% of that in H X GC3 tumors. Autoradiographs prepared from these tumors demonstrated that incorporation of radiolabel into nuclei occurred only in stromal cells derived from the host. It is anticipated that H X GC3/M TK- 100 C3 will be a line valuable for determining the role of dThd salvage in intrinsic resistance to 5-fluoropyrimidines or antifolates in human colon adenocarcinomas growing as xenografts and also the relevance of dTMp synthase as a target for antimetabolites in this histiotype.
Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers. (1977)

Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.
FHMESH: A Flexible Heterogeneous Mesh Networking Platform (2010)

Cyber-Physical Systems require the integration of various heterogeneous networks. To evaluate proposed algorithms in network research, real-world test beds are an indispensable complement to simulations. In this paper, we present a flexible heterogeneous mesh networking platform (FHMESH) which interconnects various heterogeneous networks, i.e. wireless sensor network, wireless mesh network, FM radio network and the Internet. FHMESH builds agile and universal gateways using software defined radio technology, and the gateways form mesh backbone to interconnect those heterogeneous networks. Then, we present the platform architecture and the specific implementation details for FHMESH, and carry out some preliminary experiments. Even though the testing results of our system are not so perfect, we believe that the integration of various heterogeneous networks makes FHMESH work as a prototype for heterogeneous network research, and the flexible and universal gateway can facilitate the cross-layer research.
A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group. (1992)

These results confirm the efficacy and safety of tacrine in some patients with Alzheimer's disease. After 12 weeks, the magnitude of the treatment effect is clinically important and recognized by the physician and caregiver. Liver toxicity is reversible and easily detected by weekly alanine aminotransferase determinations.
Out of order floating point coprocessor for RISC V ISA (2015)

Floating point operations are important and essential part of many scientific and engineering applications. Floating point coprocessor (FPU) performs operations like addition, subtraction, division, square root, multiplication, fused multiply and accumulate and compare. Floating point operations are part of ARM, MIPS, and RISC-V etc. instruction sets. The FPU can be a part of hardware or be implemented in software. This paper details an architectural exploration for floating point coprocessor enabled with RISC-V [1] floating point instructions. The Floating unit that has been designed with RISC-V floating point instructions is fully compatible with IEEE 754-2008 standard as well. The floating point coprocessor is capable of handling both single and double precision floating point data operands in out-of-order for execution and in-order commit. The front end of the floating point processor accepts three data operands, rounding mode and associated Opcode fields for decoding. Each floating point operation is tagged with an instruction token for in-order completion and commit. The output of the floating point unit is tagged with either single or double precision results along with floating point exceptions, if any, based on the RISC-V instruction set. The coprocessor for floating point integrates with integer pipeline. The proposed architecture for floating point coprocessor with out-of-order execution, in-order commit and completion/retire has been synthesized, tested and verified on Xilinx Virtex 6 xc6vlx550t-2ff1759 FPGA. A system frequency of 240MHz for single precision floating point and 180 MHz double precision floating point operations has been observed on FPGA.
Appetite for Discovery (2016)

Professor Carolyn Nadeau’s research reveals how — in history, culture and identity — we truly are what we eat.
Adaptive equalization in oversampled subbands (2002)

The potential presence of fractional delays, non-minimum phase parts, and a colouring of the channel output can require adaptive equalizers to adapt very long filters, which can have slow convergence for LMS-type adaptive algorithms. These problems can be addressed by a subband approach to reduce computational complexity and improve convergence speed. We discuss, why amongst other possibilities of subband processing the oversampled approach is particularly appealing to significantly reduce computational complexity and improve convergence speed. Simulation results for typical systems found in acoustics and communication channels are presented and highlight the benefit of our method.
Thermodynamic properties and phase diagram of silicon from first-principles (1995)

We present a scheme to compute the thermodynamic properties and the phase stability of materials based on parameter-free microscopic quantum theory. Taking Si as an example we show that properties like the specific entropy, volume, and heat capacity can be accurately calculated for various phases such as solid, liquid, and amorphous. In particular this allows us to accurately locate phase boundary in the full p-T diagram as well as to elucidate macroscopic thermodynamic properties of materials in terms of microscopic viewpoint.
STEP's review of ICAAC: the ultimate battle must be won by the immune system. (1999)

Issues discussed at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) are presented. A presentation by Dr. Anthony Fauci of the National Institute of Health (NIH) on the control of HIV, particularly Alatent pools@ of HIV-infected CD4 cells, is described. Fauci recommends achieving adequate control by having a competent immune system, enhancing the weakened immune system, and purging the reservoir of latently-infected cells. In addition, a presentation on treatment failure by Dr. John Mellors is also discussed in detail. Mellors' suggestions include checking drug levels, studying the rate of progression, and considering prior drug experience, before resorting to salvage therapy. Results of trials featuring efavirenz, abacavir, and Saquinavir are described. Summaries of other topics addressed at ICAAC, including a new class of drugs called fusion inhibitors, are provided.
Fabrication of Barium Titanate Single Crystals by Solid‐State Grain Growth (1994)

BaTiO 3 single crystals were prepared by solid‐state grain growth. The single crystals were obtained by seeding a poly‐crystalline, TiO 2 ‐excess BaTiO 3 , which exhibited abnormal grain growth. The condition for single‐crystal growth was essentially dependent on the grain growth behavior of the polycrystalline, sintered bodies. The annealing temperature suitable for the single‐crystal growth was just below the critical temperature of abnormal grain growth in TiO 2 ‐excess BaTiO 3 , which is about 1300°C.
Quantitative characterization of site-occupancies in minerals (1983)

Site-occupancies in minerals may be derived by a variety of experimental methods. The use of these methods is briefly reviewed here and particular attention is paid to the problems and limitations associated with the derivation of quantitative site-occupancies from experimental data. Diffraction methods are the most highly developed of these techniques, and for two species disordered over two or more sites can yield results the precision of which is dependent on the difference in the scattering powers of the atoms involved. Mdssbauer spectroscopy is used primarily for Fe2* and Fe3* site-occupancy determinations. The precision of the results depends on the resolution of the spectrum; with decreasing resolution, parameter correlation becomes a problem in the spectrum refinement and precision is strongly decreased. Hydroxyl-band infrared spectroscopy has been used for site-occupancy determinations in OH-bearing minerals. However, this method is affected by clustering, and if it is to be used for quantitative site-occupancy determinations, either the absence of clustering has to be demonstrated or the method has to be further developed to allow for clustering. There has recently been considerable development in the use ofelectronic absorption spectroscopy for qualitative site-occupancy studies. Some quantitative work is now appearing, and there is considerable potential here for further development. Other methods used for qualitative or semi-quantitative work-'pray diffraction, X-ray photoelectron diffraction, X-ray and neutron diffraction powder profile-refinement, nuclear magnetic resonance spectroscopy, electron paramagnetic resonance spectroscopy-have potential for fully quantitative work, but more development is required. Each method has its own area of particular usefulness, and these methods should be viewed as complementary rather than mutually exclusive.
[Effects of transcatheter closure of extracardiac Fontan fenestration by Amplatzer duct or septal occluder in three patients]. (2008)

The Amplatzer septal or duct occluder device is a safe and effective strategy for the Fontan fenestration occlusion.
Data management issues in vehicle control systems: a case study (2003)

We present a case study of a class of embedded hard real-time control applications in the vehicular industry which, in addition to meeting transaction and task deadlines, emphasize data validity requirements. We elaborate on how a database could be integrated into the studied application and how the database management system (DBMS) could be designed to suit this particular class of systems.
Enhancing Förster Resonance Energy Transfer (FRET) Efficiency of Titania–Lanthanide Hybrid Upconversion Nanomaterials by Shortening the Donor–Acceptor Distance (2020)

Several robust titania (TiO<sub>2</sub>) coated core/multishell trivalent lanthanide (Ln) upconversion nanoparticles (UCNPs) hybrid architecture designs have been reported for use in photodynamic therapy (PDT) against cancer, utilizing the near-infrared (NIR) excited energy down-shifting and up-conversion chain of Nd<sup>3+</sup> (λ<sub>793-808 nm</sub>) → Yb<sup>3+</sup> (λ<sub>980 nm</sub>) → Tm<sup>3+</sup>(λ<sub>475 nm</sub>) → TiO<sub>2</sub> to produce reactive oxygen species (ROS) for deep tissue-penetrating oxidative cytotoxicity, e.g., NaLnF<sub>4</sub>:Yb,Tm (Ln = Y, Gd). Herein, we demonstrate that by doping the Tm<sup>3+</sup> emitter ions in the outer shell and the Nd<sup>3+</sup> sensitizer ions in the core, the newly designed NaYF<sub>4</sub>:Nd,Yb@Yb@Yb,Tm@TiO<sub>2</sub> hybrid UCNPs exert more ROS production than the reference NaYF<sub>4</sub>:Yb,Tm@Yb@Nd,Yb@ TiO<sub>2</sub> with the Tm<sup>3+</sup> ions in the core and the Nd<sup>3+</sup> ions in the outer shell, upon 793 nm laser irradiation, primarily due to the shortening of the Tm<sup>3+</sup>-TiO<sub>2</sub> distance of the former with greater Förster resonance energy transfer (FRET) efficiency. After coating with polyallylamine hydrochloride (PAH)/polyethylene glycol folate (PEG-FA), the resulting NaYF<sub>4</sub>:Nd,Yb@Yb@Yb,Tm@TiO<sub>2</sub>-PAH-PEG-FA hybrid nanocomposites could be internalized in MDA-MB-231 cancer cells, which also show low dark cytotoxicity and effective photocytotoxicity upon 793 nm excitation. These nanocomposites could be further optimized and are potentially good candidates as nanotheranostics, as well as for other light-conversion applications.
Plasma treatment of polycarbonate for improved adhesion (2002)

The deposition of silicon alloys for protective and optical coatings on polymers is of increasing interest. The understanding of the plasma polymer interaction is of prime importance here. In this work, we report a study of the influence of N2, H2, and O2 plasma treatments on pure and commercial grade polycarbonate (PC) in order to enhance the adhesion of plasma deposited silica films. Treatments and depositions were carried out in a low pressure (1 mTorr range) integrated distributed 2.45 GHz microwave electron cyclotron resonance reactor, which allows the deposition of dense stoechiometric silica at room temperature. The plasma–polymer interaction is studied by in situ UV-visible spectroscopic ellipsometry on thin spin-coated PC films. The absorption in the PC layer was found to increase in the UV which was attributed to the different reaction products of photo-Fries rearrangements, especially for pure PC. Gel permeation chromatography measurements showed that the major influence of plasma treatment on pure polycarbonate is chain scission opposed to crosslinking in the case of commercial grade PC, indicating that additives present in commercial grade PC play a major role in the crosslinking mechanisms. The plasma treatment modifies the top 330 nm/homogeneously and no indication of a high index surface layer (50–200 nm) or gradient was found. This is attributed to the low pressure of the plasma treatment, which makes a redeposition of volatile organic species unlikely.
Cardiac gating using scattering of an 8‐channel parallel transmit coil at 7T (2017)

We have shown that the scattering of a pTx RF coil can be used to estimate a cardiac signal, and that scattering matrix and coefficients can be used to cardiac gate MRI acquisitions with the scattering matrix providing a superior cardiac signal. Magn Reson Med 80:633-640, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
New method for estimating wavefront from curvature signal by curve fitting (1995)

We present a new method to estimate the wavefront with the curvature-sensing technique proposed by F. Roddier. Instead of solving a Poisson equation for the curvature signal, we estimate the wavefront by direct least-squares curve fitting of the curvature signal with derivatives of Zernike polynomials. It is computationally simpler and faster. From computer simulations, it is shown that the curve-fitting method gives quite accurate wavefront estimation. It is especially useful when only a fixed number of aberration modes are of interest, as in the optical-axis adjustment of a telescope.
Uniformly Carbon-Covered Alumina and Its Surface Characteristics (2005)

Uniformly carbon-covered alumina (CCA) was prepared via the carbonization of sucrose highly dispersed on the alumina surface. The CCA samples were characterized by XRD, XPS, DTA-TG, UV Raman, nitrogen adsorption experiments at 77 K, and rhodamine B (RB) adsorption in aqueous media. UV Raman spectra indicated that the carbon species formed were probably conjugated olefinic or polycyclic aromatic hydrocarbons, which can be considered molecular subunits of a graphitic plane. The N(2) adsorption isotherms, pore size distributions, and XPS results indicated that carbon was uniformly dispersed on the alumina surface in the as-prepared CCA. The carbon coverage and number of carbon layers in CCA could be controlled by the tuning of the sucrose content in the precursor and impregnation times. RB adsorption isotherms suggested that the monolayer adsorption capacity of RB on alumina increased drastically for the sample with uniformly dispersed carbon. The as-prepared CCA possessed the texture of alumina and the surface properties of carbon or both carbon and alumina depending on the carbon coverage.
High resolution 2D dose measurement device based on a few long scintillating fibers and tomographic reconstructiona) (2012)

Using tomographic reconstruction on the projections acquired with rotating scintillating fibers, we were able to perform water-equivalent 2D dosimetry of square fields and IMRT segments with acceptable accuracy and high spatial resolution. The underlying concept of tomographic dosimetry and the small number of fibers needed to reconstruct a given 2D dose distribution offer new dosimetric possibilities, both applicable to 2D and 3D dosimetry.
A high performance position tracker for embedded paging, cellular telephone, and law enforcement applications (2003)

A highly compact and secure municipal area personnel tracking device is described. Position updates to a nominal accuracy of 20 meters for up to 1000 active users are required. Coverage over paging and cellular phone service areas, including most interior office space, is provided. The system is protected from unauthorized position monitoring and from jamming. Dependent tracking and independent tracking are considered. The selected tracking system uses a user beacon operating in the 900 MHz range, the signal emitted by each user consisting of 0.1-s bursts sent every 100 s. A time-bandwidth of 100000 is utilized to overcome high link attenuations and interference. To meet spoof and position-denial requirements, one-time bursts are used in each time slot. A custom all-digital signal correlation system was developed to meet the high processing gain and programmability requirements of master and remote monitor sites. Acquisition times are reduced by transmit time and time interval synchronization obtained over the existing paging or cellular-phone receive link.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>