gebhart/patrepeval huggingface dataset:
Biomechanical Comparison of Flexible Stainless Steel and Titanium Nails with External Fixation Using a Femur Fracture Model (2006)

There are several options available for surgical stabilization of pediatric femoral shaft fractures. The purpose of this study was to compare the stability afforded by Ender stainless steel nails, titanium elastic nails, and one-plane unilateral external fixators for the fixation using a synthetic adolescent midshaft femur fracture model. The anterior-posterior (sagittal plane) bending, lateral (coronal plane) bending, torsional, and axial stiffness values were calculated using 6 different fixation configurations. These included pairs of 3.5-mm-diameter Ender nails with and without distal locking, 3.5- and 4.0-mm-diameter titanium elastic nails as well as single- and double-stacked monolateral external fixators. Eight synthetic femur models, 4 each with simulated transverse and comminuted fracture patterns, were sequentially tested for stability afforded by the various fracture fixation configurations. External fixation exhibited significantly greater control of anterior-posterior angulation compared with all flexible-nailing systems. Although Ender nails were slightly superior to titanium nails in control of sagittal plane angulation, this was not statistically significant. Compared with the external fixation constructs, all 4 flexible nail constructs demonstrated higher torsional stability. For prevention of axial shortening, all fixation methods were similar for the transverse fracture pattern, whereas external fixation was superior to flexible nails in the comminuted fracture model. No significant benefit was demonstrated with double stacking of external fixators. These findings may help guide clinicians choose the optimal fixation method for treatment of pediatric femoral shaft fractures.
General Melting Point Prediction Based on a Diverse Compound Data Set and Artificial Neural Networks (2005)

We report the development of a robust and general model for the prediction of melting points. It is based on a diverse data set of 4173 compounds and employs a large number of 2D and 3D descriptors to capture molecular physicochemical and other graph-based properties. Dimensionality reduction is performed by principal component analysis, while a fully connected feed-forward back-propagation artificial neural network is employed for model generation. The melting point is a fundamental physicochemical property of a molecule that is controlled by both single-molecule properties and intermolecular interactions due to packing in the solid state. Thus, it is difficult to predict, and previously only melting point models for clearly defined and smaller compound sets have been developed. Here we derive the first general model that covers a comparatively large and relevant part of organic chemical space. The final model is based on 2D descriptors, which are found to contain more relevant information than the 3D descriptors calculated. Internal random validation of the model achieves a correlation coefficient of R(2) = 0.661 with an average absolute error of 37.6 degrees C. The model is internally consistent with a correlation coefficient of the test set of Q(2) = 0.658 (average absolute error 38.2 degrees C) and a correlation coefficient of the internal validation set of Q(2) = 0.645 (average absolute error 39.8 degrees C). Additional validation was performed on an external drug data set consisting of 277 compounds. On this external data set a correlation coefficient of Q(2) = 0.662 (average absolute error 32.6 degrees C) was achieved, showing ability of the model to generalize. Compared to an earlier model for the prediction of melting points of druglike compounds our model exhibits slightly improved performance, despite the much larger chemical space covered. The remaining model error is due to molecular properties that are not captured using single-molecule based descriptors, namely both inter- and intramolecular interactions and crystal packing, for which examples of and reasons for outliers are given.
A case‐based construction method for a fault‐restoration support system in secondary power systems (1992)

Abstract The authors have already clarified that case‐based reasoning (CBR) is very useful for the fault‐restoration support system in electrical power networks. This paper describes the case‐based construction method, adaptation and modification method of a case which is a fundamental process of CBR, and the results of evaluation. The following points were clarified through the simulations of fault restoration under various conditions with electrical power networks of practical scale: (1) a case‐based construction method and the guide to the selection of cases which should be included in the case were made clear. Restoration plans which include many cases are registered in the base. Cases which would require long computation time are also registered in the case base. In the application which requires high‐speed processing, such as fault restoration, there exists an optimum value in the total numbers of cases in the case base; (2) the function of load switching which is essential to perform adaptation and modification of a case flexibly was studied and embedded in the system herein. Inference power was augmented by the implemented of this function, and optimum for suboptimum solutions were obtained. Processing time with CBR is considerably shorter than other methods, and this feature is remarkable with complicated cases.
Reciprocity theorems for one-way wavefields (1996)

Acoustic reciprocity theorems have proved their usefulness in the study of forward and inverse scattering problems. The reciprocity theorems in the literature apply to the two-way (i.e. total) wavefield, and are thus not compatible with one-way wave theory, which is often applied in seismic exploration. By transforming the two-way wave equation into a coupled system of one-way wave equations for downgoing and upgoing waves it appears to be possible to derive ‘one-way reciprocity theorems’ along the same lines as the usual derivation of the ‘two-way reciprocity theorems'. However, for the one-way reciprocity theorems it is not directly obvious that the ‘contrast term’ vanishes when the medium parameters in the two different states are identical. By introducing a modal expansion of the Helmholtz operator, its square root can be derived, which appears to have a symmetric kernel. This symmetry property appears to be sufficient to let the contrast term vanish in the above-mentioned situation. The one-way reciprocity theorem of the convolution type is exact, whereas the one-way reciprocity theorem of the correlation type ignores evanescent wave modes. The extension to the elastodynamic situation is not trivial, but it can be shown relatively easily that similar reciprocity theorems apply if the (non-unique) decomposition of the elastodynamic two-way operator is done in such a way that the elastodynamic one-way operators satisfy similar symmetry properties to the acoustic one-way operators.
Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β (2012)

The poor prognosis of glioblastoma (GBM) routinely treated with ionizing radiation (IR) has been attributed to the relative radioresistance of glioma-initiating cells (GIC). Other studies indicate that although GIC are sensitive, the response is mediated by undefined factors in the microenvironment. GBM produce abundant transforming growth factor-β (TGF-β), a pleotropic cytokine that promotes effective DNA damage response. Consistent with this, radiation sensitivity, as measured by clonogenic assay of cultured murine (GL261) and human (U251, U87MG) glioma cell lines, increased by approximately 25% when treated with LY364947, a small-molecule inhibitor of TGF-β type I receptor kinase, before irradiation. Mice bearing GL261 flank tumors treated with 1D11, a pan-isoform TGF-β neutralizing antibody, exhibited significantly increased tumor growth delay following IR. GL261 neurosphere cultures were used to evaluate GIC. LY364947 had no effect on the primary or secondary neurosphere-forming capacity. IR decreased primary neurosphere formation by 28%, but did not reduce secondary neurosphere formation. In contrast, LY364947 treatment before IR decreased primary neurosphere formation by 75% and secondary neurosphere formation by 68%. Notably, GL261 neurospheres produced 3.7-fold more TGF-β per cell compared with conventional culture, suggesting that TGF-β production by GIC promotes effective DNA damage response and self-renewal, which creates microenvironment-mediated resistance. Consistent with this, LY364947 treatment in irradiated GL261 neurosphere-derived cells decreased DNA damage responses, H2AX and p53 phosphorylation, and induction of self-renewal signals, Notch1 and CXCR4. These data motivate the use of TGF-β inhibitors with radiation to improve therapeutic response in patients with GBM.
High–NA Camera for an EUVL Microstepper (2014)

Extreme ultraviolet lithography (EUVL) is a promising next-generation technology for extending the ability of microelectronics manufacturers to make ever denser circuits with smaller features, a trend known as Moore’s
1.25-Gbit/s photon-counting optical communications using a two-element superconducting nanowire single photon detector (2006)

The sensitivity of a high-rate photon-counting optical communications link depends on the performance of the photon counter used to detect the optical signal. In this paper, we focus on ways to reduce the effect of blocking, which is loss due to time periods in which the photon counter is inactive following a preceding detection event. This blocking loss can be reduced by using an array of photon counting detectors or by using photon counters with a shorter inactive period. Both of these techniques for reducing the blocking loss can be employed by using a multi-element superconducting nanowire single-photon detector. Two-element superconducting nanowire single-photon detectors are used to demonstrate error-free photon counting optical communication at data rates of 781 Mbit/s and 1.25 Gbit/s.
A fundamental approach to transformer thermal modeling. II. Field verification (2001)

For pt.I see ibid., vol.16, no.2, p.171-5 (2001). This paper has two main objectives. One is to show that the top oil rise thermal model proposed in part I is valid, for a large power transformer in service. The second is to show that there is a convenient way of estimating the parameters without removing the transformer from service. A Manitoba Hydro 250 MVA OFAF transformer was chosen and instrumented with data-gathering equipment. Two twenty-four hour test runs were performed, one in February of 1999 and the other in July of 1999. The most basic parameter to be determined was the rated top oil rise but also found were the top oil line constant and the nonlinearity exponent, commonly given the symbol n. The results are very positive.
Hydration in organic crystals: prediction from molecular structure (1991)

The proportion of non-ionic, metal free, organic compounds that crystallise as hydrates increases, within the class, with an increase in the number of hydrogen-bond acceptor groups with respect to the donor groups.
Purification and properties of the deoxyribonucleic acid polymerase induced by vaccinia virus. (1979)

The vaccinia virus-induced DNA polymerase has been purified about 500-fold from a cytoplasmic extract of vaccinia-infected HeLa cells. Analysis of the purified fraction by sodium dodecyl sulfate-polyacrylamide gel electrophoresis reveals a single polypeptide of 110,000 daltons, which is greater than 95% pure. This polypeptide co-sediments with polymerase activity through a glycerol gradient. The sedimentation coefficient of the enzyme is 6.3 S, and its Stokes radius is 4.6 nm. The molecular weight of the native enzyme derived from these values is 115,000. Vaccinia polymerase is therefore a single large polypeptide of 110,000 to 115,000 daltons. The purified fraction has no significant endonuclease activity, but a strong exonuclease activity co-purifies with polymerase activity through every step in the isolation. The polymerase and exonuclease activities are inactivated at 45 degrees C at the same rate. It is likely, therefore, that both activities are catalyzed by the same polypeptide. The exonuclease hydrolyzes DNA predominantly in the 3' leads to 5' direction, to produce 5' mononucleotides. The exonuclease degrades single-stranded DNA more rapidly than duplex DNA, and the rate of digestion of both single-stranded and double-stranded DNA increases as the size of the substrate decreases. Single-stranded circular DNA is a potent inhibitor of the exonuclease activity, but duplex circular DNA has no significant effect on its activity.
<title>Four-dimensional B-spline-based motion analysis of tagged cardiac MR images</title> (1999)

In recent years, with development of new MRI techniques, noninvasive evaluation of global and regional cardiac function is becoming a reality. One of the methods used for this purpose is MRI tagging. In tagging, spatially encoded magnetic saturation planes, tags, are created within tissues. These act as temporary markers and move with the tissue. In cardiac tagging, tag deformation pattern provides useful qualitative and quantitative information about the functional properties of underlying myocardium. The measured deformation of a single tag plane contains only unidirectional information of the past motion. In order to track the motion of a cardiac material point, this sparse, single dimensional data has to be combined with similar information gathered from other tag sets and all time frames. Previously, several methods have been developed which rely on the specific geometry of the chambers. Here, we employ an image plane based, simple cartesian coordinate system and provide a stepwise method to describe the heart motion using a four-dimensional tensor product of B-splines. The proposed displacement and forward motion fields exhibited sub-pixel accuracy. Since our motion fields are parametric and based on an image plane based coordinate system, trajectories or other derived values (velocity, acceleration, strains...) can be calculated for any desired point on the MRI images. This method is sufficiently general so that the motion of any tagged structure can be tracked.
Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence (2006)

Drug transporters are membrane proteins that provide protection for organisms against natural toxic products and fungicides. In plant pathogens, drug transporters function in baseline sensitivity to fungicides, multidrug resistance (MDR) and virulence on host plants. This paper describes drug transporters of the filamentous fungi Aspergillus nidulans (Eidam) Winter, Botrytis cinerea Pers and Mycosphaerella graminicola (Fückel) Schroter that function in fungicide sensitivity and resistance. The fungi possess ATP-binding cassette (ABC) drug transporters that mediate MDR to fungicides in laboratory mutants. Similar mutants are not pronounced in field resistance to most classes of fungicide but may play a role in resistance to azoles. MDR may also explain historical cases of resistance to aromatic hydrocarbon fungicides and dodine. In clinical situations, MDR development in Candida albicans (Robin) Berkhout mediated by ABC transporters in patients suffering from candidiasis is common after prolonged treatment with azoles. Factors that can explain this striking difference between agricultural and clinical situations are discussed. Attention is also paid to the risk of MDR development in plant pathogens in the future. Finally, the paper describes the impact of fungal drug transporters on drug discovery.
Efficient Inorganic Deoxyribonucleases. Greater than 50-Million-Fold Rate Enhancement in Enzyme-Like DNA Cleavage (2000)

Glycosylated natural products such as bleomycin, neocarzinostatin, and calicheamicin γ1 are efficient antitumor agents that cleave ds DNA by pathways that involve redox chemistry. In this paper we demonstrate the use of metalloderivatives of natural aminoglycosides as efficient DNA cleavage agents in the absence of external reducing agents. Kinetic characterization of DNA cleavage by copper neamine under Michaelis−Menten-"type" reaction conditions revealed a maximal reaction velocity Vmax' = 0.031 min-1, equivalent to a greater than 50-million-fold rate enhancement in DNA cleavage, when uncorrected for catalyst concentrations. Under true Michaelis conditions, a maximal reaction velocity Vmax = 0.0595 min-1 was obtained (with kcat = 5.95 × 10-4 min-1), corresponding to a million-fold rate enhancement using micromolar concentrations of Cu2+−neamine. The specificity constants for DNA cleavage by copper neamine (kcat/KM = 4.8 × 105 h-1 M-1) are 2 orders of magnitude greater than those reported elsewhere for synthetic compounds, at this time. Cleavage mediated by Cu2+−(kanamycin A) was found to be even more efficient. DNA cleavage was not inhibited by SOD, NaN3, DMSO, or EtOH, nor by handling under anaerobic conditions. The results of gel electrophoretic experiments provide clear evidence for a hydrolytic cleavage pathway with generation of 5'-phosphate and 3'-hydroxyl termini.
Chalcogenide glasses in active plasmonics (2010)

Abstract The phase‐change technology behind rewritable optical disks and the latest generation of electronic memories can also offer high contrast plasmonic switching functionality. Numerical simulations illustrate the extent of this potential while preliminary experiments show that a silver/gallium‐lanthanum‐sulphide interface can support surface plasmon‐polaritons and demonstrate the principle of plasmonic modulation through reversible photo‐induced changes in the chalcogenide. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
In vitro assembly of a functional nucleocapsid from the negative-stranded genome RNA of a defective interfering particle of vesicular stomatitis virus. (1988)

The template for transcription and replication of negative-stranded RNA viruses is a ribonucleoprotein structure, the nucleocapsid. We have developed a system that supports assembly of the negative-stranded RNA genome of a defective interfering (DI) particle of vesicular stomatitis virus (VSV) into a nucleocapsid in vitro. This system uses extracts from wild-type VSV-infected cells as a source of proteins to encapsidate the RNA. In vitro assembled nucleocapsids were compared to in vivo-derived nucleocapsids by the following characteristics: nuclease resistance of the encapsidated RNA, CsCl density banding of labeled RNA in a position coincident with nucleocapsids, correct sedimentation rate in sucrose gradients, the presence of the nucleocapsid protein on the nucleocapsids, and the infectivity of the in vitro assembled nucleocapsids. We conclude that the system we present is capable of assembling the isolated genome of a rhabdovirus DI particle into nucleocapsids indistinguishable from those produced during the course of intracellular DI replication.
Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species. (1992)

The cDNA sequence of the B chain of thrombin (EC 3.4.21.5) has been determined from nine vertebrate species (rat, mouse, rabbit, chicken, gecko, newt, rainbow trout, sturgeon, and hagfish). The amino acid sequence identities vary from 96.5% (rat vs. mouse) to 62.6% (newt vs. hagfish). Of the 240 amino acids spanned in all the species compared, there is identity at 110 (45.8%) positions. When conservative changes are included, the amino acid similarity increases to 75%. The most conserved portions of the B chain are the active-site residues and adjacent amino acids, the B loop, and the primary substrate-binding region. In addition, the Arg-Gly-Asp motif is conserved in 9 of the 11 species compared, and the chemotactic/growth factor domain is well conserved in all of the 11 species compared. The least conserved regions of the B chain correspond to surface loops, including the putative thrombomodulin-binding sites and one of the hirudin-binding regions. The extent of the amino acid sequence similarity and the conservation of many of the functional/structural motifs suggests that, in addition to their role in blood coagulation, vertebrate thrombins may also play an important role in the general mechanisms of wound repair.
Embryogenesis and plant regeneration in <i>Brassica napus</i> anther cultures (1977)

Anthers of two cultivars of Brassica napus were cultured on a medium previously used for B. campestris but modified with the addition of 100 mg/ℓ L-serine. The frequency of embryogenic anthers obtained was about 1%. Transfer of anthers from a 10% to a 2% sucrose level after 1- and 2-week culture periods failed to increase the number of embryos obtained and did not result in the production of embryos capable of direct development into plantlets. Although most embryos obtained in this study lacked the ability to develop a shoot system, plants were recovered by inducing shoot formation on hypocotyl expiants cultured on a cytokinin-containing medium.A total of 31 plants were regenerated, 9 of which were examined cytologically and found to be diploid. triploid, or tetraploid. Evidence for the microspore origin of the plants was accumulated and possible mechanisms of diploidization and polyploidization were considered.
Optimal Spectrum Sharing in MIMO Cognitive Radio Networks via Semidefinite Programming (2011)

In cognitive radio (CR) networks with multiple-input multiple-output (MIMO) links, secondary users (SUs) can exploit "spectrum holes" in the space domain to access the spectrum allocated to a primary system. However, they need to suppress the interference caused to primary users (PUs), as the secondary system should be transparent to the primary system. In this paper, we study the optimal secondary-link beamforming pattern that balances between the SU's throughput and the interference it causes to PUs. In particular, we aim to maximize the throughput of the SU, while keeping the interference temperature at the primary receivers below a certain threshold. Unlike traditional MIMO systems, SUs may not have the luxury of knowing the channel state information (CSI) on the links to PUs. This presents a key challenge for a secondary transmitter to steer interference away from primary receivers. In this paper, we consider three scenarios, namely when the secondary transmitter has complete, partial, or no knowledge about the channels to the primary receivers. In particular, when complete CSI is not available, the interference-temperature constraints are to be satisfied with high probability, thus resulting in chance constraints that are typically hard to deal with. Our contribution is fourfold. First, by analyzing the distributional characteristics of MIMO channels, we propose a unified homogeneous quadratically constrained quadratic program (QCQP) formulation that can be applied to all three scenarios, in which different levels of CSI knowledge give rise to either deterministic or probabilistic interference-temperature constraints. The homogeneous QCQP formulation, though non-convex, is amenable to semidefinite programming (SDP) relaxation methods. Secondly, we show that the SDP relaxation admits no gap when the number of primary links is no larger than two. A polynomial-time algorithm is presented to compute the optimal solution to the QCQP problem efficiently. Thirdly, we propose a randomized polynomial-time algorithm for constructing a near-optimal solution to the QCQP problem when there are more than two primary links. Finally, we show that when the secondary transmitter has no CSI on the links to primary receivers, the optimal solution to the QCQP problem can be found by a simple matrix eigenvalue-eigenvector computation, which can be done much more efficiently than solving the QCQP directly.