gebhart/patrepeval huggingface dataset:
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. (1999)

In sepsis there is extensive apoptosis of lymphocytes, which may be beneficial by down-regulating the accompanying inflammation. Alternatively, apoptosis may be detrimental by impairing host defense. We studied whether Bcl-2, a potent antiapoptotic protein, could prevent lymphocyte apoptosis in a clinically relevant model of sepsis. Transgenic mice in which Bcl-2 was overexpressed in T cells had complete protection against sepsis-induced T lymphocyte apoptosis in thymus and spleen. Surprisingly, there was also a decrease in splenic B cell apoptosis in septic Bcl-2 overexpressors compared with septic HeJ and HeOuJ mice. There were marked increases in TNF-alpha, IL-1beta, and IL-10 in thymic tissue in sepsis in the three species of mice, and the increase in TNF-alpha and IL-10 in HeOuJ mice was greater than that in Bcl-2 mice. Mitotracker, a mitochondrial membrane potential indicator, demonstrated a sepsis-induced loss of membrane potential in T cells in HeJ and HeOuJ mice but not in Bcl-2 mice. Importantly, Bcl-2 overexpressors also had improved survival in sepsis. To investigate the potential impact of loss of lymphocytes on survival in sepsis, Rag-1-/- mice, which are totally deficient in mature T and B cells, were also studied. Rag-1-/- mice had decreased survival compared with immunologically normal mice with sepsis. We conclude that overexpression of Bcl-2 provides protection against cell death in sepsis. Lymphocyte death may be detrimental in sepsis by compromising host defense.
Effects of overlaps, stitches, and patches on multilayer insulation (1972)

The effects of spacecraft installation-type discontinuities on aluminized Mylar multilayer insulation have been measured using an electrically heated cylindrical calorimeter. The experimental results have been reproducible within plus or minus 10% or better for identical blankets and less than plus or minus 5% for the same blanket. Good blanket performance can be obtained using short interleaving for joints, eliminating stitched seams, and using small patches, particularly over the hot side of stitches. The heat loss through stitching is excessive but highly localized. Analytical models matched to thermocouple test results are presented. The manner in which radiation and conduction participate in heat transfer adjacent to discontinuities is indicated. High lateral heat transfer is also established as an important phenomenon in the vicinity of a discontinuity.
A Tutorial on Fingerprint Recognition 1 (2008)

Abstract. This tutorial introduces fingerprint recognition systems and their main components: sensing, feature extraction and matching. The basic technologies are surveyed and some state-of-the-art algorithms are discussed. Due to the extent of this topic it is not possible to provide here all the details and to cover a number of interesting issues such as classification, indexing and multimodal systems. Interested readers can find in [21] a complete and comprehensive guide to fingerprint recognition. 1
Undrained Bearing Capacity of Two-Strip Footings on Spatially Random Soil (2006)

A probabilistic study on the interference of two parallel rough rigid strip footings on a weightless soil with a randomly distributed undrained shear strength performed. The problem is studied using the random finite element method, where nonlinear finite element analysis is merged with random field theory within a Monte Carlo framework. The variability of undrained shear strength is characterized by a lognormal distribution and an exponentially decaying spatial correlation length. The estimated bearing capacity statistics of isolated and two footings cases are compared and the effect of footing interference discussed. Although interference between footings on frictionless materials is not very great, the effect is shown to be increased by soil variability and spatial correlation length.
Electrical and magnetic properties of rock and soil (1983)

Magnetic permeability is calculated from measurements of magnetic susceptibility made at 1(P cps. These values are applicable over this frequency range 102 to ID** cps because magnetic permeability is nearly constant in this range.
Magnetic Induction Framework Synthesis: A General Route to the Controlled Growth of Metal–Organic Frameworks (2017)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMagnetic Induction Framework Synthesis: A General Route to the Controlled Growth of Metal–Organic FrameworksHaiqing Li*†∥, Muhammad Munir Sadiq‡, Kiyonori Suzuki‡, Paolo Falcaro§, Anita J. Hill∥, and Matthew R. Hill*†∥View Author Information† Department of Chemical Engineering, Monash University, Clayton, Victoria 3800, Australia∥ CSIRO, Clayton, Victoria 3168, Australia‡ Department of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia§ Institute of Physical and Theoretical Chemistry, Graz University of Technology, Graz 8010, Austria*H. Li. E-mail: [email protected]*M. R. Hill. E-mail: [email protected]Cite this: Chem. Mater. 2017, 29, 15, 6186–6190Publication Date (Web):June 12, 2017Publication History Received3 May 2017Revised12 June 2017Published online14 June 2017Published inissue 8 August 2017https://pubs.acs.org/doi/10.1021/acs.chemmater.7b01803https://doi.org/10.1021/acs.chemmater.7b01803rapid-communicationACS PublicationsCopyright © 2017 American Chemical SocietyRequest reuse permissionsArticle Views2684Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystallization,Crystals,Magnetic properties,Metal organic frameworks,Nanoparticles Get e-Alerts
GIP-Overexpressing Mice Demonstrate Reduced Diet-Induced Obesity and Steatosis, and Improved Glucose Homeostasis (2012)

Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that potentiates glucose-stimulated insulin secretion during a meal. Since GIP has also been shown to exert b-cell prosurvival and adipocyte lipogenic effects in rodents, both GIP receptor agonists and antagonists have been considered as potential therapeutics in type 2 diabetes (T2DM). In the present study, we tested the hypothesis that chronically elevating GIP levels in a transgenic (Tg) mouse model would increase adipose tissue expansion and exert beneficial effects on glucose homeostasis. In contrast, although GIP Tg mice demonstrated enhanced b-cell function, resulting in improved glucose tolerance and insulin sensitivity, they exhibited reduced diet-induced obesity. Adipose tissue macrophage infiltration and hepatic steatosis were both greatly reduced, and a number of genes involved in lipid metabolism/inflammatory signaling pathways were found to be downregulated. Reduced adiposity in GIP Tg mice was associated with decreased energy intake, involving overexpression of hypothalamic GIP. Together, these studies suggest that, in the context of over-nutrition, transgenic GIP overexpression has the potential to improve hepatic and adipocyte function as well as glucose homeostasis.
Rapid, Simple Paraffin Processing of Small Biopsies (1979)

Small biopsies of human tissues were rapidly processed through paraffin, utilizing fixation in 10% neutral buffered formalin, alcoholic formalin or Perfix, and dehydration in 2,2-dimethoxypropane. Rapidly processed slide. sections of liver, kidney, lung, striated muscle, spleen, skin, thyroid and breast carcinoma compared favorably with similar routinely processed tissue counterparts in regard to morphologic detail, cytologic clarity and staining properties. Eosinophilia appeared moderately increased after rapid processing. Tissue preservation appeared best after Perfix fixation with either processing schedule. The shortened processing schedule provides a quick, simple, convenient, permanent section of selected biopsy specimens. The method offers a simple alternative to lengthy routine processing, shortened schedule with heat and vacuum, or frozen sections, with the concomitant advantage of reliable diagnosis of biopsy material received on the same day.
<title>Hybrid pyramid/neural network object recognition</title> (1994)

This work concerns computationally efficient computer vision methods for the search for and identification of small objects in large images. The approach combines neural network pattern recognition with pyramid-based coarse-to-fine search, in a way that eliminates the drawbacks of each method when used by itself and, in addition, improves object identification through learning and exploiting the low-resolution image context associated with the objects. The presentation will describe the system architecture and the performance on illustrative problems.
Fast thread migration via cache working set prediction (2011)

The most significant source of lost performance when a thread migrates between cores is the loss of cache state. A significant boost in post-migration performance is possible if the cache working set can be moved, proactively, with the thread. This work accelerates thread startup performance after migration by predicting and prefetching the working set of the application into the new cache. It shows that simply moving cache state performs poorly, and that moving the instruction working set can be even more critical than data. This paper demonstrates a technique that captures the access behavior of a thread, summarizes that behavior into a compact form for transfer between cores, and then prefetches appropriate data into the new caches based on the summary. It presents a detailed study of single-thread migration effects, and then demonstrates its utility on a speculative multithreading architecture. Working set prediction as much as doubles the performance of short-lived threads, and in a full speculative multithreading implementation, the technique is also shown to nearly double the effectiveness of the spawned threads.
Expression of Insulin-like Growth Factors (IGF)-1 and -2, IGF-binding Proteins-2 and -3, and Receptors for Growth Hormone, IGF Type-1 and -2 and Insulin in the Gastrointestinal Tract of Neonatal Calves (2004)

Growth hormone (GH), insulin-like growth factors (IGFs) and insulin influence post-natal gastrointestinal development and function. We have measured by real-time PCR the mRNA levels of IGF-1 and -2, IGF-binding proteins (IGFBPs)-2 and -3, and receptors for GH, IGF type-1 and -2, and insulin in esophagus, rumen, fundus, pylorus, duodenum, jejunum, ileum and colon of calves on days 1 and 5 of life. Levels of mRNA of measured traits were different (P < 0.05) at different gastrointestinal sites. Furthermore, mRNA levels of IGFs, IGFBPs and of receptors for GH and IGF type-1 and -2 and insulin differed (P < 0.05) on days 1 and 5. Differences in mRNA abundance of IGFs, IGFBPs and of receptors for GH, IGFs, and insulin among gastrointestinal sites on days 1 and 5 of life suggest site-specific functional importance and demonstrate that changes are the consequence of ontogenetic development and/or due to feeding.
Synthesis of bottlebrush polymers <i>via</i> transfer-to and grafting-through approaches using a RAFT chain transfer agent with a ROMP-active Z-group (2015)

A novel dithiocarbamate chain transfer agent for reversible addition–fragmentation chain transfer polymerization with a directly polymerizable Z-group was synthesized and used to make bottlebrush polymers via multiple strategies.
Axis Location of Tibial Rotation and Its Change With Flexion Angle (2000)

The magnitude and location of the axis of tibial rotation were measured at 15 degrees increments between 0 degree and 90 degrees flexion using 24 normal anatomic knee specimens, and their changes with flexion angle were investigated. The magnitude of tibial rotation was small (8.3 degrees) at 0 degree flexion, but increased rapidly as the flexion angle increased and reached a maximum rotation (31.7 degrees) at 30 degrees flexion. It then decreased again with additional flexion (24.8 degrees at 90 degrees flexion). The location of the axis was close to the tibial insertion of the anterior cruciate ligament at 0 degree flexion, gradually moving toward insertion of the posterior cruciate ligament (observed at 45 degrees and 60 degrees flexion), and then moved anteriorly again with additional flexion: the axis was approximately equidistant from the two cruciate insertions at 90 degrees flexion. The results showed that a relatively large degree of tibial rotation was possible in a normal knee and that the location of the axis remained approximately in the area between the two cruciate ligament insertions throughout the range of flexion. However, the location of the axis changed with the flexion angle within this area according to the changes in direction and tension of the cruciate ligaments and the surrounding soft tissues.
Photocatalytic Membranes for Efficient Water Treatment (2016)

Membrane processes which combine the physical separation through filtration and pollutant degradation or antibacterial properties achieved by photocatalysis in a single unit are gaining popularity as wastewater treatment alternatives. There has been considerable progress in the development of photocatalytic membranes through incorporation of metal-oxide photocatalysts to enhance the performance of the membranes. An optimum amount of the photocatalyst should be incorporated into the membrane in order to realise reasonable photocatalytic activity with minimal consequences on water flux. Besides TiO 2 loading, membrane performance is also affected by light intensity and irradiation time. This chapter highlights some of the recent progresses in photocatalytic membrane fabrication, reactor configuration and membrane application in disinfection and pollutant removal from wastewater.
A frequency reconfigurable monopole antenna based on complementary split-ring resonators (2012)

A frequency-reconfigurable microstrip monopole antenna for WLAN applications is presented. Based on a complementary split-ring resonator as the primary radiator, the antenna exhibits single or dual frequency operation that is tunable using an integrated switch. The antenna is electrically small, thanks to the split-ring structure, and exhibits similar radiation patterns for both frequency bands. Simulation results demonstrate tunable single-band and dual-band characteristics of the proposed design.
Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation (2016)

Early active MS lesions with nodular enhancement show R2* decrease but no quantitative susceptibility mapping change, reflecting myelin breakdown; late active lesions with peripheral enhancement show R2* decrease and quantitative susceptibility mapping increase in the lesion center, reflecting further degradation and removal of myelin debris; and early or late chronic nonenhancing lesions show both quantitative susceptibility mapping and R2* increase, reflecting iron accumulation.
Failure of a titanium anterior cervical plate implant: microstructural analysis of failure (1995)

The authors present the case of a failed titanium anterior cervical spine plate. The plate was contoured during implantation. Analysis of the failed implant with electron microscopy showed no metallurgical flaw to have caused the plate fracture. A crack was apparently initiated with the contouring of the plate. It was located at the weakest point in the plate (the position of the intermediate screw hole), and with subsequent stress, it propagated and led to fracture. Techniques for avoiding failure of this type are discussed.
Electrically Tunable Coherent Optical Absorption in Graphene with Ion Gel (2015)

We demonstrate electrical control over coherent optical absorption in a graphene-based Salisbury screen consisting of a single layer of graphene placed in close proximity to a gold back reflector. The screen was designed to enhance light absorption at a target wavelength of 3.2 μm by using a 600 nm-thick, nonabsorbing silica spacer layer. An ionic gel layer placed on top of the screen was used to electrically gate the charge density in the graphene layer. Spectroscopic reflectance measurements were performed in situ as a function of gate bias. The changes in the reflectance spectra were analyzed using a Fresnel based transfer matrix model in which graphene was treated as an infinitesimally thin sheet with a conductivity given by the Kubo formula. The analysis reveals that a careful choice of the ionic gel layer thickness can lead to optical absorption enhancements of up to 5.5 times for the Salisbury screen compared to a suspended sheet of graphene. In addition to these absorption enhancements, we demonstrate very large electrically induced changes in the optical absorption of graphene of ∼3.3% per volt, the highest attained so far in a device that features an atomically thick active layer. This is attributable in part to the more effective gating achieved with the ion gel over the conventional dielectric back gates and partially by achieving a desirable coherent absorption effect linked to the presence of the thin ion gel that boosts the absorption by 40%.
CCAAT Box Revisited: Bidirectionality, Location and Context (1988)

The so-called CCAAT box is believed to be a major promoter element of higher eukaryotes though it is ill-defined being deduced from very limited sequence data. The comprehensive computer analysis of an unbiased set of 168 promoters presented here removes several of the persisting uncertainties. In particular, it delineates the region of preferential occurrence of the CCAAT element to -110 to -50 relative to the initiation site, suggests that integrity of this pentamer is essential, and confirms bidirectionality as a general property of this element. Within the above region the signal is found to occur in a specific sequence context which is an important supplement to its description.
Multiframe blind deconvolution, super-resolution, and saturation correction via incremental EM (2010)

We formulate the multiframe blind deconvolution problem in an incremental expectation maximization (EM) framework. Beyond deconvolution, we show how to use the same framework to address: (i) super-resolution despite noise and unknown blurring; (ii) saturation-correction of overexposed pixels that confound image restoration. The abundance of data allows us to address both of these without using explicit image or blur priors. The end result is a simple but effective algorithm with no hyperparameters. We apply this algorithm to real-world images from astronomy and to super resolution tasks: for both, our algorithm yields increased resolution and deconvolved images simultaneously.
Cryopreserved human umbilical cord patch for <i>in‐utero</i> spina bifida repair (2015)

Cryopreserved umbilical cord graft is a promising regenerative patch for intrauterine repair of spina bifida.
Metabotropic Glutamate Receptor Activation Regulates Fragile X Mental Retardation Protein and <i>Fmr1</i> mRNA Localization Differentially in Dendrites and at Synapses (2004)

Fragile X syndrome is caused by the absence of the mRNA-binding protein Fragile X mental retardation protein (FMRP), which may play a role in activity-regulated localization and translation of mRNA in dendrites and at synapses. We investigated whether neuronal activity and glutamatergic signals regulate trafficking of FMRP and its encoding Fmr1 mRNA into dendrites or at synapses. Using high-resolution fluorescence and digital imaging microscopy in cultured hippocampal neurons, FMRP and Fmr1 mRNA were localized in granules throughout dendrites and within spines. KCl depolarization rapidly increased FMRP and Fmr1 mRNA levels in dendrites. Metabotropic glutamate receptor (mGluR) activation, in particular mGluR5 activation, was necessary for localization of FMRP into dendrites. Blockade of either PKC or internal calcium prevented mGluR-dependent localization of both FMRP and Fmr1 mRNA in dendrites. The activity-dependent localization of FMRP was not dependent on protein synthesis. Fluorescence recovery after photobleaching analysis of live neurons transfected with enhanced green fluorescent protein-FMRP revealed increased granule trafficking in response to KCl depolarization. In contrast to its dendritic localization, mGluR activation diminished FMRP, but not Fmr1 mRNA, localization at synapses. These results demonstrate regulation of FMRP and Fmr1 mRNA trafficking in dendrites and synapses in response to specific glutamatergic signals.
Phase II study of CHOP-GR therapy for advanced-stage follicular lymphoma (2006)

Recently, the cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) regimen plus rituximab (R-CHOP) have been used widely to treat patients with follicular lymphoma. We investigated a fixed scheme of combination chemotherapy protocol including CHOP, granulocyte colony stimulating factor (G-CSF) and rituximab (CHOP-GR) for patients with advanced-stage grade 1 or grade 2 follicular lymphoma in a phase II clinical trial, assessing enhancement of antibody-dependent cellular cytotoxicity of rituximab by G-CSF. Twenty-one untreated patients received two courses of CHOP chemotherapy followed by four courses of CHOP-GR, including G-CSF (s.c.) on days 11 - 14 and rituximab on day 15. Overall response rate was 76% (16 of 21 patients). Two patients, one with no response and subsequent allogeneic hematopoietic stem cell transplantation and one with progressive disease, died of lymphoma. One patient refused to continue therapy, whereas two were rediagnosed and no longer met histologic criteria; these three patients were classified as nonresponders. After a median observation time of 23 months, the 19 histologically assessable patients showed a 2-year progression-free survival rate of 82%, whereas 2-year overall survival was 95%. Fifteen patients (79%) continued in remission during this median follow-up period. Of seven patients with initial bulky mass, five responded to therapy. The most frequent adverse events were leukocytopenia (100%) and neutropenia (100%), followed in turn by alopetia (94%) and nausea/vomiting (79%). Of 11 patients examined for bcl-2 translocation in peripheral blood or marrow by polymerase chain reaction (PCR), four were positive, whereas three of the four had complete remissions and converted to PCR negativity after therapy. According to short-term observation, CHOP-GR is a safe and effective therapy for patients with advanced-stage follicular lymphoma.
Synthesis of pppGpN typs dinucleotide derivatives: the 5′ end sequence of some RNAs (1975)

A rapid and simple synthesis of pppGpN type /N equals C, U or A/ diribonucleotide derivatives is described by coupling guanosine 2', 3'-cyclic phosphate 5'-triphosphate with the appropriate ribonucleoside in the presence of ribonuclease T-1.