gebhart/patrepeval huggingface dataset:
Plasma-Controlled Cell Migration: Localization of Cold Plasma-Cell Interaction Region (2010)

In order to characterize the optimal condition for cell treatment with a plasma jet, its UV-vis-NIR spectrum was evaluated. Furthermore, this study considers the ability of cold atmospheric plasmas to impact cell migration rates as a function of (i) the length of the plasma treatment time, (ii) the number of hours after treatment that cell migration is assessed, and (iii) localization of the treatment zone. Data show that the ability of plasma to reduce cell migration rates increases as a function of treatment time with a maximum of 30%, and that this affect persists for 33 hours after plasma treatment.
Field Study on milk production and mastitis effect of the DeLaval Swinging Cow Brush (2009)

Summary A field study was performed at Sprucehaven Farm and Research Center in New York State, USA. A total of four pens with approximately 100 cows each were used in the study. There were two identical pens of approximately 100 first lactation cows, one with two DeLaval Swinging Cowbrushes (‘Cowbrush’) and one Control pen. The second set of two identical pens housed approximately 100 cows each in second or higher lactation with one pen containing two Cowbrushes and one Control pen. Daily milk production data were available for a period of approximately 3 months before the go-live date of the Cowbrushes and six months after the go-live date. Mixed model linear regression analyses were performed on the daily milk production data. The results indicated that second lactation cows showed an approximate 3.5% (1 kg) higher daily milk production while no statistically significant difference (at P<.05) was observed in first lactation or older lactation animals. Clinical mastitis data were collected before and during the field study period. Clinical mastitis was not different between the study pens before the go-live data of the Cowbrushes, however after go-live, clinical mastitis was reduced by 34% (P<.05) in the cows in second and higher lactation in the Cowbrush pen. No difference in clinical mastitis was observed in the two pens with first lactation animals. In conclusion, installation of the Cowbrushes resulted in either no difference in daily milk production (in lactation 1 and 3 and higher), or in an approximate 3.5% (1 kg) higher daily milk production. Clinical mastitis was lower in pens of cows in second and higher lactation with a Cowbrush present.
Feasibility of using a concrete mixing truck as a rheometer (2006)

Fresh concrete properties dictate the performance of the concrete in its hardened state.
Distribution of amiodarone in heart tissues following intrapericardial administration. (1999)

The distribution of amiodarone (A) in heart tissues of open chest anesthetized animals was studied at 20 and 60 min following the insertion of an isotonic solution of the drug into the pericardial sac (PS) in doses from 0.25 to 3 mg per kg body weight (BW) for pigs and after 60 min in doses of 3 to 6 mg for dogs. Most of the A absorbed by the myocardium was found in the subepicardium part of the left ventricular (LV) wall. For both species the percentage of drug absorbed by the myocardium was largely and inversely related to the dose given, while uptake by the atria was positively related to the dose and was higher than that in the subepicardial LV wall. Sixty minutes after i.v. administration of A (3.0 mg per kg BW) the drug was evenly distributed across the LV wall (16 microg per g wet tissue), which was significantly lower (p < 0.02) than that of subepicardal LV wall (30 microg) after intrapericardial (IP) administration. This study shows that satisfactory drug concentrations in predicted and specific distribution in the heart tissue were derived shortly after intrapericardial administration without measurable circulation in the blood.
Advances in Chemical Protein Modification (2015)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTAdvances in Chemical Protein ModificationOmar Boutureira*† and Gonçalo J. L. Bernardes*‡§View Author Information† Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain‡ Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, United Kingdom§ Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal*E-mail: [email protected]*E-mail: [email protected]; [email protected]Cite this: Chem. Rev. 2015, 115, 5, 2174–2195Publication Date (Web):February 20, 2015Publication History Received26 July 2014Published online20 February 2015Published inissue 11 March 2015https://doi.org/10.1021/cr500399pCopyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoicewith CC-BYlicenseArticle Views49821Altmetric-Citations768LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (5 MB) Get e-AlertsSUBJECTS:Chemical reactions,Hydrocarbons,Modification,Monomers,Peptides and proteins Get e-Alerts
Time-constrained loop pipelining (1995)

This paper addresses the problem of Time-Constrained Loop Pipelining, i.e. given a fixed throughput, finding a schedule of a loop which minimizes resource requirements. This paper proposes a methodology, called TCLP, based on dividing the problem into two simpler and independent tasks: retiming and scheduling. TCLP explores different sets of resources, searching for a maximum resource utilization. This reduces area requirements. After a minimum set of resources has been found, the execution throughput is increased and the number of registers required by the loop schedule is reduced. TCLP attempts to generate a schedule which minimizes cost in time and area (resources and registers). The results show that TCLP obtains optimal schedules in most cases.
Loss-imbalance equalization in arrayed waveguide-grating (AWG) multiplexer cascades (1995)

How to connect arrayed-waveguide-grating (AWG) multiplexers in cascade is discussed with the goal of equalizing the loss imbalance among frequency-division-multiplexed (FDM) channels. This paper proposes to average the FDM-channel loss over the cascaded multiplexers by shifting port connections between each adjacent multiplexer. A simulation predicts that, in a cascade of M periodic N/spl times/N multiplexers, shifting the connections by N/M reduces the loss imbalance from M/spl Delta//spl alpha/ to /spl Delta//spl alpha//M where /spl Delta//spl alpha/ [dB] denotes the loss imbalance per multiplexer. This improvement will extend the cascadable node number in all-optical FDM networks. The prediction is confirmed experimentally in an optical add-drop filter (M=2) constructed with a silica-based AWG 16/spl times/16 multiplexer; the largest loss difference among 15 FDM channels is reduced from 5.0 dB to 1.5 dB. This paper also reports that imperfect multiplexer periodicity due to waveguide dispersion restricts the equalizable frequency bandwidth to less than several free spectral ranges (FSR's).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Overexpression of NtPR-Q Up-Regulates Multiple Defense-Related Genes in Nicotiana tabacum and Enhances Plant Resistance to Ralstonia solanacearum (2017)

Various classes of plant pathogenesis-related proteins have been identified in the past several decades. PR-Q, a member of the PR3 family encoding chitinases, has played an important role in regulating plant resistance and preventing pathogen infection. In this paper, we functionally characterized <i>NtPR-Q</i> in tobacco plants and found that the overexpression of <i>NtPR-Q</i> in tobacco Yunyan87 resulted in higher resistance to <i>Ralstonia solanacearum</i> inoculation. Surprisingly, overexpression of <i>NtPR-Q</i> led to the activation of many defense-related genes, such as salicylic acid (SA)-responsive genes <i>NtPR1a/c</i>, <i>NtPR2</i> and <i>NtCHN50</i>, JA-responsive gene <i>NtPR1b</i> and ET production-associated genes <i>NtACC Oxidase</i> and <i>NtEFE26</i>. Consistent with the role of <i>NtPR-Q</i> in multiple stress responses, <i>NtPR-Q</i> transcripts were induced by the exogenous hormones SA, ethylene and methyl jasmonate, which could enhance the resistance of tobacco to <i>R. solanacearum</i>. Collectively, our results suggested that <i>NtPR-Q</i> overexpression led to the up-regulation of defense-related genes and enhanced plant resistance to <i>R. solanacearum</i> infection.
Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells (2008)

Priming of cytotoxic T lymphocytes (CTLs) by dendritic cells (DCs) is crucial for elimination of pathogens and malignant cells. To activate CTLs, DCs present antigenic peptide-complexed MHC class I molecules (MHC-I) that will be recognized by the CTLs with T cell receptors and CD8 molecules. Here we show that paired Ig-like receptor (PIR)-B, an MHC-I receptor expressed on antigen-presenting cells, can regulate CTL triggering by blocking the access of CD8 molecules to MHC-I. PIR-B-deficient DCs evoked CTLs more efficiently, leading to accelerated graft and tumor rejection. PIR-B(+) non-DC transfectant cells served as less efficient stimulators and targets for CTLs than PIR-B(-) cells at the effector phase in vitro. On surface plasmon resonance analysis, PIR-B and CD8alpha alpha were revealed to compete in binding to MHC-I. Our results may provide a novel strategy for regulating CTL-mediated immunity and diseases in a sterical manner.
[A study on the Th1/Th2 cytokines in the pathogenesis of human tuberculous pleuritis]. (2004)

Immunocompetent persons including patients with pleural tuberculosis, with pulmonary tuberculosis or the healthy with positive results to PPD test, showed similar systemic Th1 response to Mycobacterium bacilli. Due to the relatively lower level of systemic Th2 response, patients with pleural tuberculosis had higher systemic Th1/Th2 level and the enhancement of local Th1 and Th2 responses in the pleural cavity was a pathophysiologic characteristic of human pleural tuberculosis. Both Th1 and Th2 responses might play an important role in the pathogenesis of human pleural tuberculosis.
Citizenship: Care of the Self, Character and Personality (2000)

Recent attempts to reinvigorate citizenship have been rooted in a romantic impulse. The current nostalgia over citizenship strives to recuperate the participatory involvement of the small community with face-to-face interaction. This article advances a conception of citizenship that attends more closely to the agonistic ways that citizens have been historically constructed in order to challenge the romanticism of civic republicanism. We draw on those aspects of the Foucauldian governmentality literature concerned with the care of the self. Citizenship is a technology of government that constitutes membership in a political community that requires both self-mastery and attention to relations with others. Importance is attached to truth-telling since this is what makes one a subject of government. We argue that an historical shift occurred between the nineteenth and twentieth centuries from a subjectivity rooted in ‘character’ to one based on ‘personality’ that corresponded to changes in the prevailing form of citizenship and the practices of the self. The preoccupation with ‘building character’ involved a caring for the self that was based on striving for conformity with a set of public virtues. The emphasis on personality involved a care of the self organized around the quest for a unique self. This phase in the care of the self marks a shift in the ethical requirements of effective citizenship and as a result, represents a new form of truth-telling. We argue that these two forms of caring for the self mark a decisive mutation in the characteristics that were considered desirable for citizens to exhibit.
[An experimental study on the association of cyclin D1 oncoprotein with mutated p53 in progressive development of pulmonary tumors]. (2002)

Cyclin D₁ oncoprotein may play an important role in the oncogenesis of lung neoplasms, especially in the early stage. p53 expression increases significantly as the histological grade advances, and may correlate with the progression of pulmonary tumors and the malignant potential of tumor.
Cytosporolides A−C, Antimicrobial Meroterpenoids with a Unique Peroxylactone Skeleton from <i>Cytospora</i> sp. (2010)

Cytosporolides A-C (1-3), three caryophyllene-derived meroterpenoids with a unique peroxylactone skeleton, were isolated from cultures of the fungus Cytospora sp. Their structures were elucidated by NMR spectroscopy, and the absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke's method. Compounds 1-3 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Streptococcus pneumoniae.
Critical Evaluation of the Pulsed-Current Resistance Meter for Detection of Decay in Wood (1978)

An evaluation of a pulsed-current resistance meter ("Shigometer®", Model No. 7950) for facilitating detection of decay was performed on wood blocks of giant sequoia heartwood and of white fir sapwood. As decay progressed over a 12-week incubation period, a trend of lower meter readings was obtained, confirming reported field measurements of other workers. Variability in meter readings in situations where the range in resistance readings between sound and decayed wood is narrow (e.g., giant sequoia heartwood) and apparent inability of the meter to make readings necessary to diagnose decay at MCs common to wood in service without ground or water contact are considered to be the major limitations of the instrument. Shortcomings of the instrument, along with suggestions for improvement in meter design, are discussed.
Frequency of abnormal expression of HLA-A,B,C and HLA-DR molecules, invariant chain, and LFA-3 (CD58) in colorectal carcinoma and its impact on tumor recurrence (1991)

HLA-A,B,C and HLA-DR molecules are involved in cognate LFA-3 (CD58) in antigen-independent T-cell/target-cell interaction. T-cell-mediated host-versus-tumor response might therefore depend on the presence of both types of molecules on the surface of the target cell. To investigate whether presence or absence of these molecules in colorectal carcinoma influences the recurrence rate, 149 patients who underwent curative surgery were surveyed for a maximum of 65 months (mean, 48 months). As determined by immunohistochemistry, aberrant reduction of HLA-A,B,C determinants was observed in 34.9 and a complete loss in 8.7% of the tumor specimens. An induction of HLA-DR molecules was found in 55.0 and of the HLA-DR-associated invariant chain (Ii) in 81.9%. An abnormal reduction of LFA-3 was detected in 43.6%, while a complete loss of this structure was observed in 6.7%. Reduction/loss of HLA-A,B,C was correlated with reduction/loss of LFA-3 (p = 0.03). In contrast to the prognostic role of tumor stage and grade, the presence vs. absence of all these structures was not correlated with the recurrence rate. We conclude that, although encoded on different chromosomes, an abnormal reduction/loss of HLA-A,B,C and LFA-3 might be the consequence of one transacting down-regulating signal. However, the resulting deviant immunophenotypes do not profoundly influence survival and growth potential of residual tumor cells.
Effect of pressure on a “111”-type iron pnictide superconductor (2010)

The behavior of superconductivity of “111”-type iron pnictide superconductors, namely, LiFeAs, NaFeAs and LiFeP, is investigated at different pressures through electrical resistance measurements. For LiFeAs and LiFeP, the superconducting transition temperature T c decreases monotonously with increasing pressure, with the pressure coefficient of dT c /dP being−1.38 and−1.26 K/GPa, respectively. The T c of NaFeAs increases to a maximum value with the pressure increasing to 3 GPa; further increasing the pressure suppresses T c with the slope of dT c /dP about−3.40 K/GPa.
A STUDY ON DEFORMATIONAL BEHAVIOR OF CONCRETE ARCH DAM DUE TO SOLAR HEAT IN A DAY (1990)

Three dimensional deflections of a concrete arch dam due to solar heat in a daytime on March, July, and November were measured by the system consisting of two sets of theodolite with the launcher of a laser and the device which receives the laser. The thermal analysis using finite element method has been conducted to compare the measured deflections and estimate the behavior of arch dam by solar heat. It has been cleared that the obtained results from the thermal analysis estimate the behavior of all over the concrete arch dam with enough accuracy.
TMF ultra-high rate discharge performance (2002)

BOLDER Technologies Corporation has developed a valve-regulated lead-acid product line termed Thin Metal Film (TMF/sup TM/) technology. It is characterized by extremely thin plates and close plate spacing that facilitate high rates of charge and discharge with minimal temperature increases, at levels unachievable with other commercially-available battery technologies. This ultra-high rate performance makes TMF technology ideal for such applications as various types of engine start, high drain rate portable devices and high-current pulsing. Data are presented on very high current continuous and pulse discharges. Power and energy relationships at various discharge rates are explored and the fast-response characteristics of the BOLDER/sup R/ cell are qualitatively defined. Short-duration recharge experiments will show that devices powered by BOLDER batteries can be in operation for more than 90% of an extended usage period with multiple fast recharges.
Electromigration in Aluminum Film Stripes Coated with Anodic Aluminum Oxide Films (1973)

The effect of an anodic-Al2O3-coating on the electromigration lifetime of Al stripes is investigated. Experiments show that the mean time to failure (MTF) of Al stripes is significantly increased by the presence of the anodic Al2O3 on stripe-surfaces. In particular the most effective structure of anodic oxide film for MTF is constructed by double layers of porous and composite oxides. It is also observed that coating with the double layers of alumina films has an effect greater than that with chemical-vapor deposited SiO2 films, and that the Al stripes coated with either alumina or SiO2 films have the same activation energy as Al stripes without coating. The observed difference in MTF-improvement can be explained by the difference of mechanical characteristics of the coating films.
A 7-ns/350-mW 64-kbit ECL-compatible RAM (1987)

A 7-ns 350-mW, 64-kbit ECL RAM was developed using 1.3-/spl mu/m high-performance bipolar-CMOS (Hi-BiCMOS) technology, in which a bipolar transistor of 7-GHz cutoff frequency is fabricated together with 1.3-/spl mu/m CMOS. A variable-impedance data-line load, a common data-line equalizing circuit, and a sense-amplifier selection technique together achieve a 7-ns access time. Gates combining bipolar and CMOS devices achieve a power dissipation of one-third that of conventional bipolar 64-kb ECL RAMs.
Inhibition of nonhomologous end joining to increase the specificity of <scp>CRISPR</scp>/Cas9 genome editing (2015)

DNA repair, one of the fundamental processes occurring in a cell, safeguards the genome and maintains its integrity. Among various DNA lesions, double-strand breaks are considered to be the most deleterious, as they can lead to potential loss of genetic information, if not repaired. Nonhomologous end joining (NHEJ) and homologous recombination are two major double-strand break repair pathways. SCR7, a DNA ligase IV inhibitor, was recently identified and characterized as a potential anticancer compound. Interestingly, SCR7 was shown to have several applications, owing to its unique property as an NHEJ inhibitor. Here, we focus on three main areas of research in which SCR7 is actively being used, and discuss one of the applications, i.e. genome editing via CRISPR/Cas, in detail. In the past year, different studies have shown that SCR7 significantly increases the efficiency of precise genome editing by inhibiting NHEJ, and favouring the error-free homologous recombination pathway, both in vitro and in vivo. Overall, we discuss the current applications of SCR7 to shed light on the unique property of the small molecule of having distinct applications in normal and cancer cells, when used at different cellular concentrations.
Coronary Arteriography by the Single Catheter Percutaneous Femoral Technique (1974)

A new percutaneous femoral method for studying the coronary arteries, left ventricle and saphenous vein bypass grafts using a single catheter has been developed. A #8 French 100 cm polyurethane catheter with wire incorporated and a 45° curved tip has been used in 6,800 patients. This technique combines the speed and simplicity of the percutaneous femoral approach with the safety of the single catheter technique by eliminating multiple catheter and guidewire changes. Manipulation techniques for selective right and left coronary artery and saphenous vein bypass graft injections as well as for left ventriculography are described. In only 10% of the cases has it been necessary to change to a second catheter, and catheterization time has averaged less than 15 minutes. Complications have been infrequent: femoral thrombosis 0.3%, hematoma 0.2%, myocardial infarction 0.04%, cerebrovascular accident 0.03% and death 0.07%. The speed of the technique and the elimination of multiple catheter changes seem to have contributed to the low complication rate.
Estudio de impacto ambiental : planos de anexo 1 : plantas de vegetacion (2004)

This environmental assessment for the Mexico - Transport Corridors, presents recommendations for mitigating impacts during construction of the corridor. Recommendations include: selection of construction yards for storage of materials and transportation equipment; avoid dust propagation caused by earth removal and smoke generated by trucks; use of noise control techniques on noisy equipment, such as the use of machinery equipped with appropriate mufflers; proper handling of demolition debris in accordance existing regulations of the Government of Mexico City; affected land and vegetation will be restored to its original conditions; temporary work camps are to provide facilities for garbage and sanitary waste management; and spray with water using pressurized water jets to control dust, specially during dry or windy weather. A manual and training on environmental good practices will be offered to construction, administrative personnel, administrators of materials, and subcontracting staff.