The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The "Pseudogout Syndrome" (1962)

Article1 May 1962The Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The "Pseudogout Syndrome"I. Clinical AspectsDANIEL J. MCCARTY JR., M.D., NORMAN N. KOHN, M.D., JAMES S. FAIRES, M.D.DANIEL J. MCCARTY JR., M.D.Search for more papers by this author, NORMAN N. KOHN, M.D.Search for more papers by this author, JAMES S. FAIRES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-5-711 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of a rapid, simple technique for the specific identification of urate crystals in gouty synovial fluid also resulted in the discovery of non-urate crystals in the affected joints of two patients (1). One case displayed the typical clinical features of acute gouty arthritis except for a normal serum urate level. This finding led us to examine microscopically numerous fluids from arthritic joints; we succeeded in finding non-urate crystals in six additional cases. Fluid from one of these patients, a known gouty arthritic, also showed urate crystals. The seven (non-gouty) patients showed clinical and roentgenographic similarities.Crystals from six...References1. MCCARTYHOLLANDER DJJL: The identification of urate crystals in gouty synovial fluid. Ann. Intern. Med. 54, 452, 1961. LinkGoogle Scholar2. KohnHUGHESMCCARTYFAIRES NNREDJJS: The significance of calcium phosphate crystals in the synovial fluid of arthritic patients; the "pseudogout syndrome." II. Identification of crystals. Ann. Intern. Med. 56: 738, 1962. LinkGoogle Scholar3. MCCARTY DJ: Phagocytosis of urate crystals in gouty synovial fluid. Arthritis Rheum. 4: 425, 1961. Google Scholar4. FAIRESMCCARTY JSDJ: Unpublished data. Google Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Arthritis Section, Department of Medicine, Hahnemann Medical College and Hospital, 230 North Broad Street, Philadelphia, Pennsylvania.Supported in part by research grant A-4626 and training grant 2A-5201, National Institute of Arthritis and Metabolic Disease, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Daniel J. McCarty, Jr., M.D., Department of Medicine, Hahnemann Medical College and Hospital, 230 North Broad Street, Philadelphia, Pennsylvania. 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MCCARTY JR., chondrocalcinosis of pyrophosphate in synovial fluid and study of articular cartilage in pyrophosphate or calcium pyrophosphate dihydrate crystal deposition pseudogout and in the knee of a with as a of Calcium Crystal Deposition Clinical Years The of the Crystal Caused by Calcium as a in with of in the Synovial M.D., M.D., M.D., M.D., induced arthritis in PYROPHOSPHATE IN AND OF PYROPHOSPHATE associated with calcium pyrophosphate dihydrate in and the crystal deposition PYROPHOSPHATE Pyrophosphate Crystal and the of and human and human of collagen in synovial and for the of and after prosthetic knee arthroplasty: Identification of in the synovial studies on crystals in from two cases of associated with chronic with leukocyte in II. effect of urate crystals and urate in by and and the OF of Joint IN of in the of Rheumatoid die der Chondrocalcinosis and of the Knee with and Rheumatoid in arthritisThe of a in inflammatory synovial from of cartilage Diseases and Clinical Significance of Acid in Synovial J. JR., M.D., M.D., J. acute associated with crystal Associated with Calcification of of Synovial Fluid as a in Gout, and the model of acute in the of Chondrocalcinosis Bone and Changes in a case of in of Acid and in of in Elderly on the of Rheumatoid Joint The and a Working M.D., J. MCCARTY JR., M.D., M.D., of in the Aspects of Fluid in Joint in the of and Arthritis of American and of Years J. M.D., M.D., M.D., M.D., M.D., M.D., M.D., M.D., M.D., M.D., M.D., J. M.D., after injection of acute arthritis in chronic with Crystals in Synovial M.D., M.D., JR., M.D., W. of Calcium Phosphate Dihydrate Crystals in Human for of and II: of New Anti-Inflammatory in Acute of Acid and Its to of and Its and new of acute gouty arthritisThe Significance of Calcium Phosphate Crystals in the Synovial Fluid of Arthritic Patients: The "Pseudogout II. Identification of N. KOHN, M.D., J. MCCARTY JR., M.D., JAMES S. FAIRES, May May & by The American College of