gebhart/patrepeval huggingface dataset:
Possible Role of Ammonia on the Deposition, Retention, and Absorption of Nicotine in Humans while Smoking<sup>†</sup> (2007)

This perspective presents an overview of the properties of tobacco smoke aerosol and the possible effect of ammonia on the deposition location, retention and the amount and rate of nicotine absorption during cigarette smoking. Three main mechanisms describe the absorption of smoke constituents: (A) gas-phase constituents deposit directly; (B) particles deposit and the constituents then diffuse through the particle into the biological buffer and then into the tissue; and (C) particulate phase constituents evaporate from the particles and then deposit from the gas phase. Nicotine from smoking deposits and is absorbed predominately in the lungs. When particles deposit on the lung-blood interfaces, nicotine is absorbed rapidly, regardless of the acid-base nature of the particles. This is due to the buffering capacity of the lung-blood interfaces and the small mass of nicotine per puff distributed over a large number of particles depositing onto a huge lung surface. The composition of both tobacco smoke aerosol particles and the gas phase are time dependent. Ammonia in mainstream smoke evaporates faster from particles than nicotine. It is, therefore, unlikely that ammonia can significantly affect the volatility of MS smoke nicotine from particles in the smoke aerosol. It is certain that no single measurement of tobacco or of smoke, especially one made under equilibrium conditions, can adequately characterize the time-dependent properties of mainstream smoke aerosol. Thus, the fraction of nonprotonated freebase nicotine in trapped, aged smoke particulate matter has not been shown to be a useful predictor of the amount or total rate of nicotine uptake in human smokers. Similarly, "smoke pH" and "pHeff" are not useful practical parameters for providing understanding or predictability of tobacco smoke chemistry or nicotine bioavailability.
Pharmacogenetics of SSRIs and Sexual Dysfunction (2010)

Sexual dysfunction (SD) is a common and disconcerting side effect of selective serotonin reuptake inhibitors (SSRIs) that often influences a patient’s desire to continue long-term antidepressant treatment. Studies specifically assessing changes in sexual well-being over time illustrate that the incidence of sexual side effects from SSRIs ranges from 20% to 70%, depending on the characteristics of the study sample assessed. Developing strategies to predict who may be at the highest risk for adverse changes in their sexual well-being is an important step in improving the quality of life and treatment of patients who require antidepressant therapy. Pharmacogenetic studies of SSRI-associated SD have identified associations between serotonin and glutamate system genes with aspects of SD. The results of studies investigating genetic variations in drug metabolism enzymes and their relationships to antidepressant-associated adverse effects have been mixed. Continued efforts to characterize the relationships between genetic markers and antidepressant outcomes, and to translate this knowledge to patient care, have the potential to significantly improve the empiric selection of antidepressant agents and to minimize the risk for intolerable side effects.
An RNA that Multiplies Indefinitely with DNA-Dependent RNA Polymerase: Selection from a Random Copolymer (1973)

We have selected from a mixture of random polynucleotides an RNA that is able to replicate in the presence of the DNA-dependent RNA polymerase of Escherichia coli, provided the medium contains Mn(2+) and ITP, in addition to ATP, CTP, and UTP. The RNA consists of a chain of about 125 (+/-25) nucleotides and appears to have a defined, nonrepetitive sequence.
Increased expression of the c-myc gene without gene amplification in human lung cancer and colon cancer cell lines. (1986)

High levels of c-myc mRNA were observed in two human tumor cell lines, a giant cell carcinoma of the lung (C-Lu99) and a colon cancer (C1). The increased expression of c-myc in these cell lines, which was comparable with those in cell lines in which the c-myc gene is amplified, was not due to gene amplification. Run-on transcription revealed that the transcriptional rate of the c-myc gene was greatly increased in these cell lines.
Online predictive model fitting algorithm for supply inductance estimation (2015)

This paper presents a finite control set Model Predictive Control (FS-MPC) approach for a grid-connected converter, particularly suitable for non-stiff grids where under low Short Circuit Ratio (SCR) the performance of the controller may get affected by variations in supply impedance value. In order to avoid this problem, a novel supply inductance estimator that is based on the grid currents variations between consecutive sampling instants fully integrated in the MPC algorithm, is proposed. The estimation is carried out in real-time and updates the predictive controller at every sampling instant, thus providing a quick adaptability to a change in supply inductance. Moreover, by knowing the estimated value of the supply impedance, the phase and amplitude difference between grid voltage and the voltage at the point of common coupling is compensated. The proposed approach has been verified through simulation and experiments on a 3-phase 2-level active front-end converter.
The Frontal Air-Sea Interaction Experiment (FASINEX); Part II: Experimental Plan (1986)

The Frontal Air-Sea Interaction Experiment (FASINEX) is a study of the response of the upper ocean to atmospheric forcing in the vicinity of an oceanic front in the subtropical convergence zone southwest of Bermuda, the response of the lower atmosphere in that vicinity to the oceanic front, and the associated two-way interaction between ocean and atmosphere. FASINEX is planned for the winter and spring of 1985/86 with an intensive period in February and March 1986 in the vicinity of 27°N, 70°W, where sea-surface-temperature fronts are climatologically common. Measurements will be made from buoys, ships, aircraft, and spacecraft. A previous article gave a brief history of FASINEX and presented its scientific goals. This article describes the FASINEX experimental plan.
Phylogenetic Analysis of the Species<i>Theilovirus</i>: Emerging Murine and Human Pathogens (2008)

The Cardiovirus genus of the family Picornaviridae includes two distinct species, Encephalomyocarditis virus and Theilovirus. We now report the complete nucleotide sequences of three Theiler's murine encephalomyelitis virus (TMEV) strains (TO Yale, TOB15, and Vie 415HTR) and of Vilyuisk human encephalomyelitis virus (VHEV). This information, together with the recently reported sequences of divergent theiloviruses (Theiler's-like rat virus [TRV] and Saffold viruses 1 and 2 [SAFV-1 and SAFV-2]), enables an updated phylogenetic analysis as well as a reexamination of several gene products important in the pathogenesis of this emerging group of viruses. In the light of the known neurotropism of TMEV and the new human SAFV-1 and SAFV-2, the resulting data suggest the existence of theiloviruses that cause human central nervous system infections. Our phylogenetic analyses point to the classification of presently known theiloviruses into five types: TMEV, VHEV, TRV, SAFV-1, and SAFV-2.
Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population (2019)

Plant height (PH) is an important trait in soybean, as taller plants may have higher yields but may also be at risk for lodging. Many genes act jointly to influence PH throughout development. To map the quantitative trait loci (QTL) controlling PH, we used the unconditional variable method (UVM) and conditional variable method (CVM) to analyze PH data for a four-way recombinant inbred line (FW-RIL) population derived from the cross of (Kenfeng14 × Kenfeng15) × (Heinong48 × Kenfeng19). We identified 7, 8, 16, 19, 15, 27, 17, 27, 22, and 24 QTL associated with PH at 10 developmental stages, respectively. These QTL mapped to 95 genomic regions. Among these QTL, 9 were detected using UVM and CVM, and 89 and 66 were only detected by UVM or CVM, respectively. In total, 36 QTL controlling PH were detected at multiple developmental stages and these made unequal contributions to genetic variation throughout development. Among 19 novel regions discovered in our study, 7 could explain over 10% of the phenotypic variation and contained only one single QTL. The unconditional and conditional QTL detected here could be used in molecular design breeding across the whole developmental procedure.
Rainfall downscaling in an alpine watershed applying a multiresolution approach (2003)

Distributed hydrological modeling in alpine watersheds needs high‐resolution (∼1 km in space, 1 h in time) rainfall input. Spatial resolution of operational numerical weather forecast or regional climate models is coarser by at least one order of magnitude. Stochastic downscaling of meteorological model output is the appropriate way to bridge this scale gap. This study examines radar data in an orographically complex area in the southern European Alps by multiplicative multiresolution decomposition. Multiresolution rainfall fluctuations exhibit simple scaling characteristics. This result motivates the implementation of a spatial downscaling model, an example of an anisotropic microcanonical multiplicative random cascade, that is applied and evaluated. Necessity and skill of downscaling is illustrated by hydrological modeling of four heavy precipitation events in an Alpine watershed (total area of 2627 km 2 ) with the grid‐based model WaSiM‐ETH. Downscaling of rainfall fields with 16 km grid spacing to fields with 1 km grid spacing improves the simulated event‐mean runoff by 5–10% and the peak runoff by up to 20%.
Low-complexity, robust algorithm for sensor anomaly detection and self-calibration of microphone arrays (2011)

This study details a simple method for the detection of sensor degradation in microphone arrays and equalisation of the microphone gains. The described method is online in nature and based upon the long-term power spectra of the microphone signals of each array. The close proximity of the microphones within an array is essential for the application of the proposed detection and calibration method. The approach is tested on three sample degradation scenarios: complete sensor failure, non-linearity in the input and parasitic harmonic injection. While these scenarios are by no means exhaustive, they represent the most typical degradations in many applications. The results indicate that the developed approach is capable of detecting such failures. Further, the calibration factors computed using the proposed approach are similar to that obtained by established methods.
Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase (1997)

We have generated a transgenic mouse line that overexpresses the rate-controlling enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase. Tissues of these mice showed markedly distorted polyamine pools, which in most cases were characterized by the appearance of N1-acetylspermidine, not normally found in mouse tissues, a massive accumulation of putrescine, and decreases in spermidine and/or spermine pools. The most striking phenotypic change was permanent hair loss at the age of 3 to 4 weeks which was typified histologically by the appearance of extensive follicular cysts in the dermis. The effect seemed attributable to putrescine interference with hair development, possibly with differentiation/proliferation of epidermal cells located in hair follicles. Female members of the transgenic line were found to be infertile apparently due to ovarian hypofunction and hypoplastic uteri. The findings demonstrate the utility of spermidine/spermine N1-acetyltransferase overexpression as an effective means for genetically modulating total tissue polyamine pools in transgenic animals and examining the developmental and oncogenic consequences.
A historical overview of flight flutter testing (1995)

This paper reviews the test techniques developed over the last several decades for flight flutter testing of aircraft. Structural excitation systems, instrumentation systems, digital data preprocessing, and parameter identification algorithms (for frequency and damping estimates from the response data) are described. Practical experiences and example test programs illustrate the combined, integrated effectiveness of the various approaches used. Finally, comments regarding the direction of future developments and needs are presented. INTRODUCTION
Online estimation and monitoring of local permeability in resin transfer molding (2014)

Resin transfer molding (RTM) is a popular manufacturing method of composite materials, which have been widely used in many areas including aeronautic, automotive industries, etc. In RTM, permeability of fiber reinforcement varies with its geometric formation and affects the property of resin flow, which influences the final product quality. Therefore, effective estimation of permeability is crucial to achieving good process control and satisfactory quality product. In this article, a method of online estimating and monitoring local permeability is proposed. It can deal with variation in local permeability within preform caused by irregular arrangement of fibers among different regions. This study is divided into three stages. In the first stage, flow visualization was realized and all hardware was integrated to acquire real‐time information in resin filling period. In the second stage, local pressure and flow front location were substituted into the Darcy's law, thus making online calculation of local permeability feasible. Then, in the third stage, the statistical process control charting technique was adopted to identify the changes in permeability. The proposed methods were used in trial RTM tests to compare their results to those from the reference method and to confirm their effectiveness. POLYM. COMPOS. 37:1249–1258, 2016. © 2014 Society of Plastics Engineers
Low-loss high-speed speckle reduction using a colloidal dispersion (2013)

We present a simple and robust approach to reduce laser speckle, which has limited the adoption of lasers in imaging and display applications. We use colloidal solutions that can quickly reduce speckle contrast due to the Brownian motion of the scattering particles. The high insertion loss associated with propagation through a colloidal solution was overcome by using white paint to cover the sides of the cuvette and an optical fiber to deliver the laser light deep into the colloidal solution, enabling transmission greater than 90%. The diffused laser output followed a Lambertian distribution and produced speckle contrast below 4% at an integration time of 129 μs. The ability for colloidal solutions to achieve fast speckle reduction without power consumption while maintaining high transmission, low cost, a compact size, and a long lifetime makes our approach useful for a wide range of laser imaging and projection applications.
Building blocks for back-junction back-contacted cells and modules with ion-implanted poly-Si junctions (2014)

We propose a process for a back-junction back-contacted solar cell (including module interconnection) combining a high efficiency potential and a lean process flow. This structure offers potential for (i) a high J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> - no optical shading losses due to the absence of front-side metallization and minimized absorption losses at the cell front-side, (ii) a high V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> - excellent passivation including “passivated contacts” based on poly-Si/c-Si junctions, and (iii) a high FF - large area contacts with low contact resistance and the absence of busbar losses due to a two-layer metallization. A lean process flow becomes feasible by utilizing two enabling technologies - in situ patterned ion implantation and module interconnection by laser welding (AMELI). We present experimental results for the main building blocks: (1) Patterned ion implantation yields an excellent recombination behavior homogeneously on 6", (2) Ion-implanted poly-Si / c-Si junctions enabling V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> values up to 742 mV and J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0e</sub> values down to 1.3fA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , (3) Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> front-side passivation enabling Jsc values up to 41.8 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and IQE values > 1 for λ <; 350 nm, and (4) busbarless, silver-free AMELI two-layer interconnection. As an intermediate step, we fabricated ion-implanted BJBC cells with conventional junctions and metallization with efficiencies up to 22.1% on 6".
Immunohistochemical Localization of a Novel Peptide, Prostacyclin-Stimulating Factor (PSF), in Human Tissues (1995)

In a recent study, we purified and cloned a newly identified bioactive factor that stimulates prostacyclin (PGI2) production by vascular endothelial cells (ECs) using conditioned medium (CM) from cultured human diploid fibroblast cells. The present study was undertaken to clarify whether PSF is expressed in ECs and vascular smooth muscle cells (SMCS) of human tissues at a protein level. In an immunohistochemical study of seven human autopsy cases, all arteries in all lungs (n = 4) and kidneys (n = 6) examined stained positive to variable extents for PGI2-stimulating factor (PSF). PSF was predominantly expressed by SMCs in the media of small arteries. Staining for PSF was weaker in SMCs of aortic media (n = 3) and strong in SMCs of vaso vasorum (n = 3). PSF staining was also found in the SMCs of human bronchi (n = 4). Immunoblot analysis confirmed that PSF is present in CM from cultured bovine aortic SMCS.
Measurement and modelling of a radiofrequency micro-thruster (2012)

A capacitively coupled radiofrequency (rf) (13.56MHz) cylindrical argon micro-discharge expanding into a larger glass tube is studied by performing optical and electrical measurements over a pressure range 0.35Torr and a rf power range 540W. Measurements
Improvement of Contact Resistance between Ru Electrode and TiN Barrier in Ru/Crystalline-Ta<sub>2</sub>O<sub>5</sub>/Ru Capacitor for 50 nm Dynamic Random Access Memory (2005)

The contact resistance ( R C ) between a Ru electrode and a TiN plug in a crystalline Ta 2 O 5 capacitor using Ru electrodes was evaluated. The TiN plug was oxidized in TiO x to increase the R C to failure. Two origins of oxygen are determined by Auger electron spectroscopy (AES) analysis, namely, the seed step of Ru deposition and the initial step of Ta 2 O 5 deposition. During Ta 2 O 5 crystallization annealing at 700°C, the oxygen molecules from Ru diffused into the TiN plug, forming TiO x . Ru films with Ti exhibited a decreased R C below 1 kΩ/contact and an increased leakage current of a Ru/Ta 2 O 5 /Ru capacitor according to the applied voltage, compared with Ru films without Ti. The atomic layer deposition (ALD) Ru process including a H 2 plasma treatment decreased the R C to 2.5 kΩ/contact on average. The fabrication scheme for the crystalline Ta 2 O 5 capacitor using the Ru electrode for reducing R C between the Ru storage node and the TiN plug was proposed.
IκB kinase: Beginning, not the end (1997)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Effects of temperature, shear rate and constituents on rheological properties of tahin (sesame paste) (2004)

Abstract In this paper, rheological properties of tahin are reported at temperatures from 20 to 70 °C and shear rates in the range 0.13–500 s −1 . Temporary hysteresis loops were observed in the first cycle of the flow curves. The steady shear behaviour of tahin was pseudoplastic and described by a power law model. The consistency coefficient exhibited strong temperature dependence for which the activation energy of flow was 21.6 kJ mol −1 . The flow behaviour index of tahin tended to increase whereas the consistency coefficient tended to decrease during storage at room temperature. Tahin oil exhibited Newtonian behaviour with a strong dependence of viscosity on temperature. The activation energy of flow for tahin oil was 35.7 kJ mol −1 . While reconstituted suspensions containing up to 20% solids exhibited Newtonian behaviour, those with more solids and the original tahin showed pseudoplastic behaviour. The Krieger–Dougherty model fitted the suspension viscosity data well. Below 20% solids level there was no effect of particle size on the viscosity of the reconstituted suspensions. It was shown that for the same amount of solids the viscosity of a ‘polydisperse’ suspension was lower than that of a ‘monodisperse’ suspension. Copyright © 2004 Society of Chemical Industry
Monoclonal antibodies specific for platelet glycoproteins react with human monocytes (1984)

Three monoclonal antibodies, P256 , P140, and P112 , react with the 135,000 mol wt IIb component of the glycoprotein IIb/IIa complex. They also react with a 200,000-mol wt protein present at low levels in the complex. Using immunofluorescence techniques, monoclonal antibodies P140 and P112 , but not P256 , can be shown to bind to 80% of human monocytes. However, P256 was able to immunoprecipitate the IIb/IIIa complex from detergent-solubilized monocytes, suggesting that the P256 epitope is less accessible on monocytes than on platelets. The monoclonal antibodies also precipitated molecules of approximately 200,000 mol wt from the monocytes. Two other monoclonal antibodies, J15 (specific for the IIb/IIIa complex) and AN51 (which reacts with the second major platelet glycoprotein complex, I), also react with monocytes. Binding of the monoclonal antibodies to the histiocytic cell line, U937, and promyelocytic cell line, HL-60, reflected the pattern of reaction with monocytes. The presence on monocytes of these glycoproteins, instrumental to the role of platelets in clotting, raises the possibility that monocytes might have similar functions in particular circumstances.