gebhart/patrepeval huggingface dataset:
Controlled Radical Polymerization of Styrene by Reverse Iodine Transfer Polymerization (RITP) in Miniemulsion:  Use of Hydrogen Peroxide as Oxidant (2006)

The use of molecular iodine I2 in controlled radical polymerization, called reverse iodine transfer polymerization, represents a new, straightforward way to prepare controlled macromolecular architectures. Herein, miniemulsion polymerization of styrene in the presence of molecular iodine has been successfully performed. The polymerization of styrene was initiated by bis(4-tert-butylcyclohexyl) peroxydicarbonate at T = 60 °C with dodecyl sulfate sodium salt as surfactant and hexadecane as hydrophobe, yielding a stable and uncolored latex. A certain amount of iodine reacted with water to form hydroiodic acid, leading to an upward deviation of the experimental molecular weight from the theoretical value. However, when the iodine lost by hydrolysis was regenerated by continuous addition of hydrogen peroxide in acidic conditions, it led to the expected molecular weight (e.g., Mn,SEC = 7900 g mol-1, Mw/Mn = 1.46, styrene conversion = 78%, Mn,theoretical = 7900 g mol-1). Hence, the molecular weight of the polymer chains could be accurately controlled by changing the concentration of iodine. Last, a chain extension was successfully performed in seeded emulsion polymerization, proving the living character of the polymerization.
Break-junction tunneling measurements of the high-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mi>c</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>superconductor<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Y</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ba</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>9</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="normal">δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> (1987)

Current-voltage tunneling characteristics in a high-critical-temperature superconducting material containing predominately ${\mathrm{Y}}_{1}$${\mathrm{Ba}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{9\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$ have been measured using the break-junction technique. Sharp gap structure was observed, with the largest superconductive energy gap measured to be \ensuremath{\Delta}=19.5\ifmmode\pm\else\textpm\fi{}1 meV, assuming a superconductor-insulator-superconductor junction. This energy gap corresponds to 2\ensuremath{\Delta}/${k}_{B}$${T}_{c}$=4.8 at T=4 K, for a critical temperature of 93 K (midpoint of the resistive transition).
Synergistic effect of PtSe<sub>2</sub> and graphene sheets supported by TiO<sub>2</sub> as cocatalysts synthesized via microwave techniques for improved photocatalytic activity (2014)

Here we report a new composite material consisting of TiO<sub>2</sub> nanoparticles grown in the presence of a layered PtSe<sub>2</sub>/graphene hybrid as a high-performance photocatalytic material.
ChemInform Abstract: 1‐(5‐Carboxyindol‐1‐yl)propan‐2‐ones as Inhibitors of Human Cytosolic Phospholipase A<sub>2</sub>α: Synthesis and Properties of Bioisosteric Benzimidazole, Benzotriazole and Indazole Analogues. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Early Cellular and Stromal Responses in Regeneration Versus Repair of a Mammalian Bladder Using Autologous Cell and Biodegradable Scaffold Technologies (2008)

Early cellular and stromal events distinguish healing processes that lead to bladder wall regeneration or repair. Construct implants containing cells elicit early healing processes that culminate with the regeneration of complete mucosal and muscular components, whereas the response to scaffold implantation is consistent with reparative healing, that is with mucosal growth but incomplete tissue layer development.
Designer Fabricator Interpreter system: evaluating alternate connection configuration through multiagent negotiation (2002)

The Designer Fabricator Interpreter (DFI) is a knowledge-based system that addresses the lack of interaction among structural designers, fabricators, and erectors in dealing with connections of structural members. Current research includes the development of a distributed problem solving architecture in which the participants are modeled as semiautonomous computer agents which reason from their own specific viewpoints while evaluating a connection. During the evaluation process, agents propose alternative connections for consideration which may require a negotiation process among the agents. If they cannot resolve the problem, an arbitrator agent is enlisted to help the conflicting agents reach an agreement. Potentially better alternative connection configurations along with the reasons behind the choices are presented from the viewpoints of design, fabrication, and field erection.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Serotonin receptor 2C and mental disorders: Genetic, expression, and RNA editing studies (2009)

Serotonin receptor 2C (HTR2C) is one of the attractive candidate genes for studying pathophysiology of mental disorders. Here we overviewed the genetic, expression and RNA editing studies suggesting the close relationship between HTR2C and major mental disorders including schizophrenia, bipolar disorder and major depression. We especially focused on the human studies as well as with reference to relevant cellular and animal models. Possible significance of genetic variations affecting expression and RNA editing and appropriate animal models that mimic human mental disorders were discussed.
Investigation into the performance characteristics of a friction turbine. (1966)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Radial conduction effects in transient heat transfer experiments (1997)

Convective heat transfer data is frequently obtained from transient surface temperature measurements. Thin film resistance gauges, thermocouples, and thermochromic liquid crystals, are used in various situations to measure the surface temperature history. By assuming that uniform semi-infinite flat plate conditions apply, it is possible to express the instantaneous surface heat flux as an analytical function of the transient surface temperature (1) . Various approaches can be used to account for the presence of multi-layered substrates and finite thickness substrate effects (Schultz and Jones (1) ; Doorly and Oldfield (2) ; Guo et al (3) ), however, the effects of surface curvature are usually neglected.
cAMP-Dependent Protein Kinase Modulates Expiratory Neurons In Vivo (1997)

The adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase (PKA) second-messenger system influences neuronal excitability by modulating voltage-regulated and transmitter-activated channels. In this study we investigated the influence of the cAMP-PKA system on the excitability of expiratory (E) neurons in the caudal medulla of anesthetized, paralyzed, and artificially ventilated adult cats. We intracellularly injected the PKA inhibitors cAMP-dependent PKA inhibitor 5-22 amide (Walsh inhibitory peptide) and Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS), the PKA activator Sp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Sp-cAMPS), and the adenylyl cyclase activator forskolin and measured membrane potential, neuronal input resistance, and synaptic membrane currents. Inhibition of cAMP-PKA activity by Walsh inhibitory peptide or Rp-cAMPS injections hyperpolarized neurons, decreased input resistance, and depressed spontaneous bursts of action potentials. Action potential duration was shortened and afterhyperpolarizations were increased. Inhibitory synaptic currents increased significantly. Stimulation of cAMP-PKA activity by Sp-cAMPS or forskolin depolarization neurons and increased input resistance. Spontaneous inhibitory synaptic currents were reduced and excitatory synaptic currents were increased. Rp-cAMPs depressed stimulus-evoked excitatory postsynaptic potentials and currents, whereas Sp-cAMPS increased them. Sp-cAMPS also blocked postsynaptic inhibition of E neurons by 8-hydroxy-dipropylaminotetralin, a serotonin-1A (5-HT-1A) receptor agonist that depresses neuronal cAMP-PKA activity. To determine the predominant effect of G protein-mediated neuromodulation of E neurons, we injected guanosine-5'-O-(3-thiotriphosphate) tetralithium salt (GTP-gamma-S), an activator of both stimulatory and inhibitory G proteins. GTP-gamma-S hyperpolarized E neurons, reduced input resistance, and increased action potential afterhyperpolarization. We conclude that the intracellular cAMP-PKA messenger system play an important role in the activity-dependent modulation of excitability in E neurons of the caudal medulla. In addition, the cAMP-PKA pathway itself is downregulated during activation of 5-HT-1A receptors.
Evidence for the importance of the "genotype" theory in alcohol seeking behavior: a commentary. (1986)

Consensus of the literature points towards a neuropsychogenetic model of alcoholism. Evidence in both animals and humans tends to support the proposed "genotype" theory of alcohol-seeking behavior, whereby a predisposition to alcohol preference may be mediated in part by either innate (genetic) or environmentally (stress and/or alcohol) induced brain opioid peptide dysfunction. Potential therapeutic rationale involving the utilization of novel inhibitors of carboxypeptidase A (enkephalinase) which raise endogenous enkephalin levels and possess anti-alcohol seeking effects is emphasized.
Effect of partial outlet obstruction on contractility: Comparison between severe and mild obstruction (1993)

Detrusor dysfunction is one of the most common problems in patients with outflow obstruction secondary to benign prostatic hyperplasia. These patients complain of various symptoms, including urinary frequency, urge incontinence, difficulty in voiding, and retention. The severity of the symptoms is dependent on the stage of disease and/or severity of the obstruction. We compared the changes in the rat detrusor function following both mild and severe models of partial outlet obstruction in the rat. Outflow obstructions were created by ligation of the urethra over which a catheter was placed. The size of the catheter determined whether the severity of obstruction was mild or severe (1.70 mm for mild obstruction and 1.09 mm for severe obstruction). Changes in the bladder weight, length-tension relationships, and the contractile response to field stimulation, pharmacologic agonists, and KCl were studied in bladders isolated from 1 and 2 week obstructed rats. Bladder weights of all obstructed rats increased significantly. The weight of the severe obstructed rats were significantly greater than rats subjected to mild obstruction. In general, passive length-tension curves of obstructed rats were shifted to right. The magnitude of the active tension induced by high KCl was higher in the mild obstruction and lower in the severe obstruction. The maximum response to KCl of mild obstruction was generated at greater lengths than for the other groups. In general, the contractile responses of the mild obstructed bladder body to field stimulation, bethanechol, KCl, and ATP, and of the bladder base to field stimulation, KCl, and methoxamine, were significantly increased when compared to the responses of the control bladder body and base. However in the severe obstructed bladder, the responses to field stimulation, KCl, ATP, and methoxamine were significantly reduced from the responses of the control strips; the response to bethanechol was similar for control and the severe obstructed groups. In conclusion, the severity of outlet obstruction significantly altered the contractile response of the bladder. Mild obstruction induced a mild increase in bladder mass, which was associated with significant increases to all forms of stimulation. Severe outflow obstruction induced a substantial increase in bladder mass and a significantly greater reduction in the response to field stimulation than the response to bethanechol (which was unchanged).
Cancer related mutations in <i>NRF2</i> impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy (2008)

The nuclear factor E2-related factor 2 (Nrf2) is a master transcriptional activator of genes encoding numerous cytoprotective enzymes that are induced in response to environmental and endogenously derived oxidative/electrophilic agents. Under normal, nonstressed circumstances, low cellular concentrations of Nrf2 are maintained by proteasomal degradation through a Keap1-Cul3-Roc1-dependent mechanism. A model for Nrf2 activation has been proposed in which two amino-terminal motifs, DLG and ETGE, promote efficient ubiquitination and rapid turnover; known as the two-site substrate recognition/hinge and latch model. Here, we show that in human cancer, somatic mutations occur in the coding region of NRF2, especially among patients with a history of smoking or suffering from squamous cell carcinoma; in the latter case, this leads to poor prognosis. These mutations specifically alter amino acids in the DLG or ETGE motifs, resulting in aberrant cellular accumulation of Nrf2. Mutant Nrf2 cells display constitutive induction of cytoprotective enzymes and drug efflux pumps, which are insensitive to Keap1-mediated regulation. Suppression of Nrf2 protein levels by siRNA knockdown sensitized cancer cells to oxidative stress and chemotherapeutic reagents. Our results strongly support the contention that constitutive Nrf2 activation affords cancer cells with undue protection from their inherently stressed microenvironment and anti-cancer treatments. Hence, inactivation of the Nrf2 pathway may represent a therapeutic strategy to reinforce current treatments for malignancy. Congruously, the present study also provides in vivo validation of the two-site substrate recognition model for Nrf2 activation by the Keap1-Cul3-based E3 ligase.
Dissolution kinetics and mechanisms in quartz- and grainite-water systems (1994)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1994.
A SU-8-based compact implantable wireless pressure sensor for intraocular pressure sensing application (2011)

Telemetric sensing has received a great deal of attention in noncontact human disease detection. To take advantage of this method, this paper presents a SU-8-based compact (1.52 mm × 3.23 mm × 0.2 mm) passive wireless pressure sensor, especially designed to measure the intraocular pressure. The sensor was microfabricated using biocompatible materials such as gold and SU-8 [1] to form the LC parallel circuit and the pressure sensitive diaphragm. The surface of the sensor is fully covered by SU-8, which isolates the working circuit from the biological tissue medium. The pressure signal can be detected by an external readout coil with up to 6 mm distance from the implanted sensor. The pressure sensitivity of the sensor was characterized in both air and saline environment. The microfabricated sensor has high sensitivity (>7,000 ppm/mmHg).
31.2: Proposal of the Perceptive Parameter Motion Picture Response Time (MPRT) (2003)

Abstract The proposed Motion Picture Response Time (MPRT) measurement is designed to represent and quantify the visual perception of moving images across an AM‐LCD screen. MPRT measurement method takes into account three basic LCD panel characteristics: the capacitive‐hold‐type brightness variations, brightness level dependent transition times and a liquid crystal response time. Further, MPRT figure is affected by a back light control method and video signal processing algorithms. The proposed measurement method incorporates the synchronously moving test pattern and the evaluation of the pattern edge brightness changes.
Chronic Norovirus Infection after Kidney Transplantation: Molecular Evidence for Immune‐Driven Viral Evolution (2010)

Norovirus infection may persist in adult renal allograft recipients with or without clinical symptoms. No evidence for nosocomial transmission in adult renal allograft recipients was found in our study. Molecular analysis suggests continuous viral evolution in immunocompromised patients who are unable to clear this infection.
Tumor necrosis factor and interleukin-1 induce expression of the verocytotoxin receptor globotriaosylceramide on human endothelial cells: implications for the pathogenesis of the hemolytic uremic syndrome (1992)

The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in vitro is potentiated by the additional exposure of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha). Preincubation of human umbilical vein endothelial cells (HUVEC) with TNF-alpha resulted in a 10- to 100-fold increase of specific binding sites for 125I-VT-1. Furthermore, interleukin-1 (IL-1), lymphotoxin (TNF-beta), and lipopolysaccharide (LPS) also markedly increase VT-1 binding. Several hours' exposure to TNF-alpha was enough to enhance the number of VT-1 receptors on the endothelial cells for 2 days. The TNF-alpha-induced increase in VT-1 binding could be inhibited by simultaneous addition of the protein synthesis inhibitor cycloheximide. Glycolipid extracts of TNF-alpha-treated cells tested on thin-layer chromatography demonstrated an increase of globotriaosylceramide (GbOse3cer), a functional receptor for VT-1, which suggests that preincubation of human endothelial cells with TNF-alpha leads to an increase in GbOse3cer synthesis in these cells. We conclude from this study that TNF-alpha and IL-1 induce one (or more) enzyme(s) that is (are) rate-limiting in the synthesis of the glycolipid VT-1 receptor, GbOse3cer. These in vitro studies suggest that, in addition to VT-1, inflammatory mediators play an important role in the pathogenesis of HUS.
A fully automated content-based video search engine supporting spatiotemporal queries (1998)

The rapidity with which digital information, particularly video, is being generated has necessitated the development of tools for efficient search of these media. Content-based visual queries have been primarily focused on still image retrieval. In this paper, we propose a novel, interactive system on the Web, based on the visual paradigm, with spatiotemporal attributes playing a key role in video retrieval. We have developed innovative algorithms for automated video object segmentation and tracking, and use real-time video editing techniques while responding to user queries. The resulting system, called VideoQ , is the first on-line video search engine supporting automatic object-based indexing and spatiotemporal queries. The system performs well, with the user being able to retrieve complex video clips such as those of skiers and baseball players with ease.
Encapsulated Living Cells on Microstructured Surfaces (2004)

The immobilization of cells in defined arrays (cell patterning) is a key step towards cell-based biosensors or other cell-based devices. While cell patterning is usually achieved by modifying the surface on which only the cells should adhere and leaving the cells unmodified, we present here a different approach in which cells are first coated with polyelectrolytes and subsequently immobilized on patterned surfaces. By coating, the cells are protected and their interactions with the substrate are modified such that patterning is simplified. We used microcontact printing of polyelectrolytes to structure surfaces such that regions of opposite charges and the same charge as the cell coating were present and found that we can thus achieve patterning of the coated yeast cells. In accordance with prior work, we find that coating does not kill the cells and coated GFP-expressing cells still function after immobilization, which we checked by fluorescence microscopy.
Metalloporphyrin‐Catalyzed Hydroxylation of Cyclohexane by Alkyl Hydroperoxides: Pronounced Efficiency of Iron‐Porphyrins (1980)

The catalytic hydroxylation of non‐activated alkanes by hydroperoxides under mild conditions has been studied on the example of cyclohexane and cumyl hydroperoxide. Of the metalloporphyrin catalysts tested, Fe(TPP)Cl was strongly effective, Mn(TPP)Cl was weakly effective, Co(TPP) and Os(TPP)(CO)(py) suffered alteration during the catalysis, while Ni, Cu, Zn, Mg, Ti, and V derivatives proved to be inactive.—In Nature alkane oxidations with O 2 are catalyzed by (iron‐containing) cytochrome P450.
3.3-kV-Class 4H-SiC MeV-Implanted UMOSFET With Reduced Gate Oxide Field (2016)

A critical issue for SiC trench gate metal-oxide- semiconductor field-effect transistors (UMOSFETs) is gate oxide shielding from the electric field at the trench bottom. In this letter, low ON-resistance with low gate electric field was achieved in a 3.3-kV-class UMOSFET with a unique hexagonal buried p-base region formed by MeV ion implantation. The shielding effect was further enhanced by a self-aligned trench bottom shielding region. The specific ON-resistance, with and without the trench bottom shielding region, was 8.3 and 9.4 mΩcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , respectively. The blocking voltage in each case was ~3800 V. The electric field in the gate oxide with the trench bottom shielding region was reduced to 2.5 MV/cm at 3300 V.
Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1<i>H</i>-1,2,3-triazoles (2009)

Novel dicationic triazoles 1-60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The type and the placement of cationic moieties as well as the nature of aromatic substituents influenced in vitro antiprotozoal activities of compounds 1-60 against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and their cytotoxicity for mammalian cells. Eight congeners displayed antitrypanosomal IC(50) values below 10 nM. Thirty-nine dications were more potent against P. falciparum than pentamidine (IC(50) = 58 nM), and eight analogues were more active than artemisinin (IC(50) = 6 nM). Diimidazoline 60 exhibited antiplasmodial IC(50) value of 0.6 nM. Seven congeners administered at 4 x 5 mg/kg by the intraperitoneal route cured at least three out of four animals in the acute mouse model of African trypanosomiasis. At 4 x 1 mg/kg, diamidine 46 displayed better antitrypanosomal efficacy than melarsoprol, curing all infected mice.