gebhart/patrepeval huggingface dataset:
Acute Thrombocytopenia Following Oral Cholecystography with lopanoic Acid (1981)

We report a case of severe thrombocytopenia following oral cholecystography with iopanoic acid, a widely used contrast medium. A bone marrow aspirate showed increased numbers of megakaryocytes, suggesting a thrombocytopenia due to enhanced peripheral destruction of platelets; this examination was not reported in the previously described two cases. Although hematological reactions due to iopanoic acid are very rare, it would be wise to question patients regarding any preceding drug-induced purpura before proceeding with oral cholecystography.
Molten salt extraction of americium from molten plutonium metal (1976)

The chemical basis for molten salt extraction separation of americium from plutonium is presented. The extraction factor relationship is used to quantify this liquid-liquid extraction (molten salt-molten metal) unit operation. The amount of salt required for an optimum process is an order of magnitude lower than the amount used previously in the production operation of the process.
Resurgence of Lymphogranuloma Venereum in Western Europe: An Outbreak of<i>Chlamydia trachomatis</i>Serovar L<sub>2</sub>Proctitis in The Netherlands among Men Who Have Sex with Men (2004)

We revealed an outbreak of LGV proctitis among MSM in The Netherlands. The ulcerous character favors transmission of HIV, other STDs, and blood-borne diseases. From a public health perspective, it seems important to increase the awareness of possible LGV in MSM with symptomatic proctitis.
Agents for process coherence in virtual enterprises (1999)

article Free Access Share on Agents for process coherence in virtual enterprises Authors: Anuj K. Jain Ericsson New Concepts Group in Research Triangle Park, NC Ericsson New Concepts Group in Research Triangle Park, NCView Profile , Manuel Aparico IBM Intelligent Agents and Knowledge Management Group, Triangle Park, NC IBM Intelligent Agents and Knowledge Management Group, Triangle Park, NCView Profile , Munindar P. Singh North Carolina State Univ., Raleigh North Carolina State Univ., RaleighView Profile Authors Info & Claims Communications of the ACMVolume 42Issue 3March 1999 pp 62–69https://doi.org/10.1145/295685.295702Published:01 March 1999Publication History 80citation949DownloadsMetricsTotal Citations80Total Downloads949Last 12 Months39Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Bacterial ghosts as adjuvant particles (2007)

The development of more advanced and effective vaccines is of great interest in modern medicine. These new-generation vaccines, based on recombinant proteins or DNA, are often less reactogenic and immunogenic than traditional vaccines. Thus, there is an urgent need for the development of new and improved adjuvants. Besides many other immunostimulatory components, the bacterial ghost (BG) system is currently under investigation as a potent vaccine delivery system with intrinsic adjuvant properties. BGs are nonliving cell envelope preparations from Gram-negative cells, devoid of cytoplasmic contents, while their cellular morphology and native surface antigenic structures remain preserved. Owing to the particulate nature of BGs and the fact that they contain many well known immune-stimulating compounds, BGs have the potential to enhance immune responses against ghost-delivered target antigens.
Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza (2018)

Rapid changes in influenza A virus (IAV) antigenicity create challenges in surveillance, disease diagnosis, and vaccine development. Further, serological methods for studying antigenic properties of influenza viruses often rely on animal models and therefore may not fully reflect the dynamics of human immunity. We hypothesized that arrays of human monoclonal antibodies (hmAbs) to influenza could be employed in a pattern-recognition approach to expedite IAV serology and to study the antigenic evolution of newly emerging viruses. Using the multiplex, label-free Arrayed Imaging Reflectometry (AIR) platform, we have demonstrated that such arrays readily discriminated among various subtypes of IAVs, including H1, H3 seasonal strains, and avian-sourced human H7 viruses. Array responses also allowed the first determination of antigenic relationships among IAV strains directly from hmAb responses. Finally, correlation analysis of antibody binding to all tested IAV subtypes allowed efficient identification of broadly reactive clones. In addition to specific applications in the context of understanding influenza biology with potential utility in "universal" flu vaccine development, these studies validate AIR as a platform technology for studying antigenic properties of viruses and also antibody properties in a high-throughput manner. We further anticipate that this approach will facilitate advances in the study of other viral pathogens.
Aspirin and reduced risk of esophageal carcinoma (1995)

Aspirin use was associated with a 90% decreased risk of developing esophageal carcinoma. Further studies to determine whether aspirin is protective against both squamous cell esophageal carcinoma and adenocarcinoma of the esophagus are indicated.
One-Pot Synthesis of α-Trimethylsilyl Enones from Vinylsilanes (1994)

Photooxygenation of vinylsilanes in the presence of acetic anhydride and pyridine afforded α-trimethylsilyl enones 1 in moderate to good yields. Since the required starting materials are readily available, the present approach constitutes a useful alternative to existing methods for the preparation of α-trimethylsilyl enones 1.
Allosteric Supramolecular Receptors and Catalysts (2004)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAllosteric Supramolecular Receptors and CatalystsLarisa Kovbasyuk and Roland KrämerView Author Information Anorganisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany Cite this: Chem. Rev. 2004, 104, 6, 3161–3188Publication Date (Web):May 19, 2004Publication History Received29 October 2003Published online19 May 2004Published inissue 1 June 2004https://pubs.acs.org/doi/10.1021/cr030673ahttps://doi.org/10.1021/cr030673aresearch-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views4125Altmetric-Citations346LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conformation,Ethers,Ions,Metals,Receptors Get e-Alerts
Anaphylactic and Anaphylactoid Reactions Associated With Lepirudin in Patients With Heparin-Induced Thrombocytopenia (2003)

Lepirudin can cause fatal anaphylaxis, particularly in patients who are treated within 3 months of a previous exposure. The overall risk/benefit assessment of lepirudin as a treatment for heparin-induced thrombocytopenia remains favorable.
Vascular Catheter Site Care: The Clinical and Economic Benefits of Chlorhexidine Gluconate Compared with Povidone Iodine (2003)

The use of chlorhexidine gluconate solution for vascular catheter insertion site care reduces the risk of catheter-related bloodstream infection by one-half, compared with povidone iodine. Our objective was to evaluate the cost-effectiveness of chlorhexidine gluconate versus povidone iodine. We used data from randomized, controlled trials, meta-analyses, and epidemiologic studies to construct a decision analysis model. We estimated that use of chlorhexidine, rather than povidone, for central catheter site care resulted in a 1.6% decrease in the incidence of catheter-related bloodstream infection, a 0.23% decrease in the incidence of death, and savings of 113 dollars per catheter used. For peripheral catheter site care, the results were similar, although the differences were smaller. The results were found to be robust on multivariate sensitivity analyses. Use of chlorhexidine gluconate in place of the current standard solution for vascular catheter site care is a simple and cost-effective method of improving patient safety in the hospital setting.
Distribution of Conjugates of Alkylphenols in Milk from Different Ruminant Species (2005)

Conjugated alkyphenols in milk constitute a reservoir for species-related alkylphenols in dairy products. The distributions of conjugated alkylphenols between different conjugation pathways (sulfation, phosphorylation, and glucuronidation) were determined in cows', sheep's, and goats' milk. Species-related p- and m-cresols and 3- and 4-ethylphenols were found to be mostly conjugated with sulfate with minor amounts associated with phosphate and glucuronide conjugates in all milks. Similar distributions were observed for alkylphenols in the urine and milk from the same ewe. Phenol was present in minor amounts distributed sporadically between different conjugates in the milks. Sulfate-conjugated phenol was not detected in the ewe's urine, which included equal amounts of glucuronide and phosphate conjugates. The amounts of alkylphenols were different in sheep's milk from different sources suggesting that there were effects of feed, breed, and individual animal variation on the metabolism of alkylphenols.
Application of Heat Pipe for Energy Saving to Air-conditioning and Ventilation System (2007)

Analyses the application of heat pipe recovery in air conditioning and ventilating system and equipments.The results show that heat pipe technology has a wide energy saving potentiality.
Rheological Behavior of Highly Concentrated Oil-in-Water (o/w) Emulsions (1995)

Oil-in-water (o/w) highly-concentrated emulsions have been studied in ternary water/polyethylene oxide -polypropylene oxide-polyethylene oxide (ABA block copolymer)/hydrocarbon systems in order to compare their rheological behavior with that of water-in-oil (w/o) highly concentrated emulsions. Viscoelastic measurements have been performed as a function of dispersed phase volume fraction and temperature. The structural parameters of the system, droplet size, interfacial tension and continuous phase viscosity have been determined in order to correlate these parameters with the rheological behavior. The shear modulus has been shown to depend on the volume fraction according to Princen's equation. The relaxation times were described using a Maxwell liquid model in which the viscosity is related to a reduced continuous phase viscosity. The effect of temperature on the shear modulus and relaxation time is significantly different from that observed for w/o highly concentrated emulsions. These differences in the rheological behavior of the emulsions weee discussed in terms of the chemical structure of the surfactants.
Phenotypic and Functional Properties of Porcine Dedifferentiated Fat Cells during the Long-Term Culture<i>In Vitro</i> (2015)

It has been proved that terminally differentiated mature adipocytes possess abilities to dedifferentiate into fibroblast-like progeny cells with self-renewal and multiple differentiation, termed dedifferentiated fat (DFAT) cells. However, the biological properties of DFAT cells during long-term culture in vitro have not been elucidated. Here, we obtained fibroblast-like morphology of porcine DFAT cells by ceiling culture. During the dedifferentiation process, round mature adipocytes with single large lipid droplets changed into spindle-shaped cells accompanied by the adipogenic markers PPARγ, aP2, LPL, and Adiponectin significant downregulation. Flow cytometric analysis showed that porcine DFAT cells displayed similar cell-surface antigen profile to mesenchymal stem cells (MSCs). Furthermore, different passages of porcine DFAT cells during long-term culture in vitro retained high levels of cell viabilities (>97%), efficient proliferative capacity including population doubling time ranged from 20 h to 22 h and population doubling reached 47.40 ± 1.64 by 58 days of culture. In addition, porcine DFAT cells maintained the multiple differentiation capabilities into adipocytes, osteoblasts, and skeletal myocytes and displayed normal chromosomal karyotypes for prolonged passaging. Therefore, porcine DFAT cells may be a novel model of stem cells for studying the functions of gene in the different biological events.
Six year experience of transvenous left ventricular lead implantation for permanent biventricular pacing in patients with advanced heart failure: technical aspects (2001)

Transverse left ventricular pacing through the coronary sinus is feasible and safe. The rate of implantation failure and of lead related problems has decreased greatly with increasing experience and with improvements in the equipment.
Mechanisms of epithelial development and neoplasia in the metanephric kidney (1999)

Recent studies on the mechanisms of normal epithelial development in the kidney, and on the aetiology of renal neoplasms, are converging to reveal remarkably close relationships between the phenotypes and behaviours of normally-developing and neoplastic cells. Normal renal epithelia arise from two sources; those of the collecting duct system develop by arborisation of an initially-unbranched ureteric bud, in a manner similar to the development of other glandular organs, while epithelial nephrons develop via an unusual mesenchyme-to-epithelial transition. Both types of development require controlled proliferation, cell-cell and cell-matrix interactions, protease activity etc., but of the two tissues, the development of the nephrons is arguably the more complex. It includes many defined stages, signals and checkpoints that ensure that events happen at the right time, and that processes such as proliferation, apoptosis and differentiation are properly balanced. Detailed investigation of renal neoplasms has revealed some to be caused by mutations in molecules with known roles in normal nephrogenesis (e.g. Wilms' tumour and the WT-1 gene, renal cell carcinoma and the c-met receptor tyrosine kinase gene), some to be caused by mutations in genes expressed during normal development (e.g. renal cell carcinoma and the TSC-2 gene, renal cell carcinoma of the clear cell variety and the VHL gene). Furthermore, these and other tumours of unknown aetiology re-express genes such as Pax-2 that are expressed during the normal mesenchyme-to-epithelium transition but are shut off during terminal differentiation. Their re-appearance in tumours suggests that the cells have 'regressed' in an ontogenic sense, and their biology may therefore be understood most clearly by reference to the properties of normal developing cells rather than cells of a mature kidney.
A Cooperative MAC Protocol for Ad Hoc Wireless Networks (2007)

Cooperative communications fully leverages the broadcast nature of the wireless channel and spatial diversity, thereby achieving tremendous improvements in system capacity and delay. By enabling additional collaboration from stations that otherwise will not directly participate in the transmission, cooperative communications ushers in a new design paradigm for wireless communications. In this paper, we extend a cooperative MAC protocol called CoopMAC into the ad hoc network environment. The new protocol is based on the idea of involving in an ongoing communication an intermediate station that is located between the transmitter and the receiver. The intermediate station acts as a helper and forwards to the destination the traffic it receives from the source. Thus, a slow one-hop transmission is transformed into a faster two-hop transmission, thereby decreasing the transmission time for the traffic being handled. Extensive simulations in a large scale wireless ad-hoc network (150 stations) show that CoopMAC significantly improves the ad hoc network performance in terms of throughput and delay, and indicate how such cooperative schemes can boost the performance of traditional solutions (e.g., IEEE 802.11)
Nucleotide sequence of the 30K protein cistron of cowpea strain of tobacco mosaic virus (1982)

The nucleotide sequence of cloned cDNA copies of cowpea strain of tobacco mosaic virus RNA including the 30K protein cistron was determined. The 30K protein cistron was located at residue 676-1,527 from the 3' end of the genomic RNA. The 30K protein was composed of 282 amino acid residues and was basic, similar to the 30K protein of common strain OM. However, homology of the amino acid sequences between the two strains was only 27%.
The Complete Set of Genes Encoding Major Intrinsic Proteins in Arabidopsis Provides a Framework for a New Nomenclature for Major Intrinsic Proteins in Plants (2001)

Major intrinsic proteins (MIPs) facilitate the passive transport of small polar molecules across membranes. MIPs constitute a very old family of proteins and different forms have been found in all kinds of living organisms, including bacteria, fungi, animals, and plants. In the genomic sequence of Arabidopsis, we have identified 35 different MIP-encoding genes. Based on sequence similarity, these 35 proteins are divided into four different subfamilies: plasma membrane intrinsic proteins, tonoplast intrinsic proteins, NOD26-like intrinsic proteins also called NOD26-like MIPs, and the recently discovered small basic intrinsic proteins. In Arabidopsis, there are 13 plasma membrane intrinsic proteins, 10 tonoplast intrinsic proteins, nine NOD26-like intrinsic proteins, and three small basic intrinsic proteins. The gene structure in general is conserved within each subfamily, although there is a tendency to lose introns. Based on phylogenetic comparisons of maize (Zea mays) and Arabidopsis MIPs (AtMIPs), it is argued that the general intron patterns in the subfamilies were formed before the split of monocotyledons and dicotyledons. Although the gene structure is unique for each subfamily, there is a common pattern in how transmembrane helices are encoded on the exons in three of the subfamilies. The nomenclature for plant MIPs varies widely between different species but also between subfamilies in the same species. Based on the phylogeny of all AtMIPs, a new and more consistent nomenclature is proposed. The complete set of AtMIPs, together with the new nomenclature, will facilitate the isolation, classification, and labeling of plant MIPs from other species.
<sup>13</sup>C NMR Spectroscopy of “Arduengo-type” Carbenes and Their Derivatives (2009)

A review. Acyclic and N-heterocyclic carbenes were studied by 13C NMR spectroscopy and DFT calcn. of chem. shift.
Home environment risk factors for falls in older people and the efficacy of home modifications (2006)

Most homes contain potential hazards, and many older people attribute their falls to trips or slips inside the home or immediate home surroundings. However, the existence of home hazards alone is insufficient to cause falls, and the interaction between an older person's physical abilities and their exposure to environmental stressors appears to be more important. Taking risks or impulsivity may further elevate falls risk. Some studies have found that environmental hazards contribute to falls to a greater extent in older vigorous people than in older frail people. This appears to be due to increased exposure to falls hazards with an increase in the proportion of such falls occurring outside the home. There may also be a non-linear pattern between mobility and falls associated with hazards. Household environmental hazards may pose the greatest risk for older people with fair balance, whereas those with poor balance are less exposed to hazards and those with good mobility are more able to withstand them. Reducing hazards in the home appears not to be an effective falls-prevention strategy in the general older population and those at low risk of falls. Home hazard reduction is effective if targeted at older people with a history of falls and mobility limitations. The effectiveness may depend on the provision of concomitant training for improving transfer abilities and other strategies for effecting behaviour change.
Alcohol and depression (2011)

The current state of the literature suggests a causal linkage between alcohol use disorders and major depression, such that increasing involvement with alcohol increases risk of depression. Further research is needed in order to clarify the nature of this causal link, in order to develop effective intervention and treatment approaches.
The magic angle effect: A source of artifact, determinant of image contrast, and technique for imaging (2007)

This review provides a formalism for understanding magic angle effects in clinical studies. It involves consideration of the fiber-to-field angle for linear structures such as tendons, ligaments, and peripheral nerves, disc-like and circular structures such as menisci and labra, as well as complex three-dimensional structures. There may be one or more fiber types with different orientations within each of these tissues. The orientation of these fibers to B(0) is crucial in determining their magic angle effect. Tissues may show a variety of appearances depending on their baseline T2, as well as the increase in T2 produced by the magic angle effect. The appearances are affected by TE, which affects both the general tissue signal level and the change in signal produced by the magic angle effect, fiber-to-slice orientation, and partial volume effects. Deliberate positioning of structures and tissues at particular orientations to B(0) can be used to increase the signal from tissues such as tendons and ligaments and so allow them to be imaged with conventional sequences. The technique can also be used to produce contrast between tissues with fibers that have different orientations to B(0).
Texturing of titanium (Ti6Al4V) medical implant surfaces with MHz-repetition-rate femtosecond and picosecond Yb-doped fiber lasers (2011)

We propose and demonstrate the use of short pulsed fiber lasers in surface texturing using MHz-repetition-rate, microjoule- and sub-microjoule-energy pulses. Texturing of titanium-based (Ti6Al4V) dental implant surfaces is achieved using femtosecond, picosecond and (for comparison) nanosecond pulses with the aim of controlling attachment of human cells onto the surface. Femtosecond and picosecond pulses yield similar results in the creation of micron-scale textures with greatly reduced or no thermal heat effects, whereas nanosecond pulses result in strong thermal effects. Various surface textures are created with excellent uniformity and repeatability on a desired portion of the surface. The effects of the surface texturing on the attachment and proliferation of cells are characterized under cell culture conditions. Our data indicate that picosecond-pulsed laser modification can be utilized effectively in low-cost laser surface engineering of medical implants, where different areas on the surface can be made cell-attachment friendly or hostile through the use of different patterns.