gebhart/patrepeval huggingface dataset:
Are pregnancy-associated serum proteins responsible for the inhibition of lymphocyte transformation by pregnancy serum? (1980)

Certain pregnancy-associated serum proteins, namely pregnancy-associated alpha 2-glycoprotein, pregnancy-specific beta 1-glycoprotein, alpha-foetoprotein, human placental lactogen and human chroionic gonadotrophin, have been proposed as immunosuppressive factors. A pregnancy serum was constructed from a number of such sera to produce high serum levels of these compounds. Each of the proteins was then removed sequentially from the serum by affinity chromatography and the remaining materials examined for inhibitory activity on lymphocyte transformation. Only the removal of pregnancy-associated alpha 2-glycoprotein decreased suppression by the serum. However, a large proportion of the serum inhibitory activity could not be accounted for, indicating the presence of other suppressor factors.
Electron Beam Irradiation Cross-linking of PVC/EVA Blend (2003)

Polyvinyl chloride (PVC) and ethylene vinyl acetate, (EVA) copolymer were cross linked by electron beam (EB) irradiation, using allylic polyfunctional monomers as cross linking sensitizer The influences of irradiation dose, cross linking sensitizer kinds and content, EVA content and vinyl acetate mass fraction in EVA on the gel mass fraction ,hot prolongation and physical properties of the blend were investigated The results showed that gel mass fraction increased with the increases of radiation dose, cross linking sensitezers, EVA and VA mass fraction The use of EVA copolymer improved the cross linking effectiveness of irradiation, and the prolongation and physical property of PVC/EVA blend were enhanced greatly by the increase of EB mass fraction
The silicon PIN diode as a microwave radar protector at megawatt levels (1964)

A silicon PIN diode developed for use as a microwave protector promises to have considerably greater reliability than gas T-R tubes. The switching action of the device results from the lowering of I layer resistance by conductivity modulation, caused either by sufficiently high microwave power levels or by applied dc bias. A theoretical analysis is presented here which yields equations for I layer resistance as a function of excitation (dc bias or microwave power). Predictions are made about the relative effectiveness of direct current or microwave power in modulating the I layer; for example, 100 ma dc bias should produce about the same injected carrier concentration as 100 kw of microwave power at 1 Gc. An experimental X-band protector consisting of an appropriately tuned PIN diode connected across a waveguide presented to low level signals an insertion loss 1 db or less when zero biased, and an insertion loss of up to 34 db at 100 ma forward bias. Measurements of temperature rise in the wafer as a function of applied X-band power indicated that the diode could protect against microwave pulses with energies of up to 38 Mw-µsec before burnout, in good agreement with theoretical predictions.
Superplastic Deformation in Fine‐Grained MgO 2Al <sub>2</sub> O <sub>3</sub> Spinel (1985)

Fine‐grained polycrystals of MgO 2A1 2 O 3 spinel were deformed to large strains at strain rates ranging from 1O ‐5 to 1O ‐3 s ‐1 and at temperatures from 1723 to 1885 K. These polycrystals were ductile at low strain rates and high temperatures; the ductility was especially remarkable at temperatures near the solvus. The mechanism of deformation, which was determined by measuring the change of flow stress with grain size, was dislocation creep, with the stress exponent in the power‐law creep equation having a value of 2.1 ± 0.4. Despite deformation of several hundred percent, the grain size remained equiaxed, and deformation led to the evolution of a grain size which depended only on the strain rate and temperature. The initial microstructure had an influence on whether the poly‐crystal would fracture or flow; a small initial grain size and a supersaturated solid solution were conducive to ductile flow. The ductility is attributed to dynamic recrystallization. It is proposed that the onset of fracture and the onset of dynamic recrystallization are competitive processes. Conditions which promote dynamic recrystallization also promote ductile flow.
A Brief Introduction to Design of Experiments (2007)

Design of experiments is a series of tests in which purposeful changes are made to the input variables of a system or process and the effects on response variables are measured. Design of experiments is applicable to both physical processes and computer simulation models. Experimental design is an effective tool for maximizing the amount of information gained from a study while minimizing the amount of data to be collected. Factorial experimental designs investigate the effects of many different factors by varying them simultaneously instead of changing only one factor at a time. Factorial designs allow estimation of the sensitivity to each factor and also to the combined effect of two or more factors. Experimental design methods have been successfully applied to several Ballistic Missile Defense sensitivity studies to maximize the amount of information with a minimum number of computer simulation runs. In a highly competitive world of testing and evaluation, an efficient method for testing many factors is needed.
ẨN DỤ Ý NIỆM TÌNH YÊU LÀ SỰ GẮN KẾT TRONG TIẾNG HÀN VÀ TIẾNG VIỆT (2019)

Miền nguồn SỰ GẮN KẾT la miền nguồn trung tâm của cac ẩn dụ ý niệm tinh yeu. Dựa tren khung tư duy phổ niệm với hệ thống chiếu xạ giữa cac yếu tố cấu truc thuộc hai miền ý niệm TINH YEU va SỰ GẮN KẾT, bai viết phân tich va so sanh tinh đặc thu của cac biểu thức ẩn dụ ý niệm TINH YEU LA SỰ GẮN KẾT trong tiếng Han va tiếng Việt. Kết quả nghien cứu cho thấy với cơ sở nghiệm thân dựa tren nhu cầu muốn được gần gũi va thực tế luon gần gũi ben nhau của những người đang yeu, ẩn dụ ý niệm TINH YEU LA SỰ GẮN KẾT la một ẩn dụ mang tinh phổ niệm cao. Cac yếu tố thuộc miền nguồn GẮN KẾT được sử dụng để cấu truc hoa ý niệm tinh yeu bao gồm đối tượng gắn kết, khoảng cach giữa cac đối tượng, mức độ va phương tiện gắn kết. Tinh yeu được tri nhận qua ẩn dụ ý niệm nay thường la tinh yeu lý tưởng. Cac khac biệt lam nen tinh đặc thu trong tiếng Han va tiếng Việt chủ yếu lien quan đến cac đặc điểm về điều kiện tự nhien, van hoa xa hội được hoa trộn trong khung tư duy phổ niệm, đặc biệt ở khia cạnh tinh duy nhất va tinh trọn vẹn của sự gắn kết. Cac đặc thu co thể mang tinh khu vực, cho thấy tinh phổ niệm trong khuon khổ van hoa phương Đong hoặc la cac đặc thu rất rieng của Han Quốc va Việt Nam, dựa tren nhận thức của người Han, người Việt về moi trường sống bao gồm cac tri thức, kinh nghiệm về động thực vật trong moi trường tự nhien, cac hiện tương quan sat thấy trong thien nhien, cac trải nghiệm trong cuộc sống sinh hoạt thường ngay như ẩm thực, dụng cụ sinh hoạt, nhạc cụ... Nghien cứu của chung toi nhằm gop phần lam ro đặc điểm tư duy va ngon ngữ trong tiếng Han va tiếng Việt, đong gop cho cac nghien cứu lien quan về giảng dạy hoặc dịch thuật tiếng Han va tiếng Việt.
Contamination-insensitive differential capacitive pressure sensors (2000)

In this paper, a contamination-insensitive differential capacitive pressure sensor with a sealed gap is presented. This device is made of three polysilicon layers including a stationary middle plate and the top and bottom plates that are rigidly coupled together by a series of posts hence deflecting in tandem by a change in differential or gauge pressure. Because of the posts, however, the device is insensitive to common-mode pressure. As the differential pressure is changed from -70 to 70 kPa, the capacitance between the bottom and middle plates changes by 73 fF (sensitivity of approximately 0.5 fF/kPa), yet there is only a 2-fF change in output when the common-mode pressure is changed from 30 to 200 kPa. The devices have a linearity error on the order of -15% FSS and a temperature coefficient of offset of 170 ppm//spl deg/C.
AT&#x00026;T's Photonic Network (2008)

AT&T's photonic network provides the bandwidth to enable the large growth that is needed to meet evolving customer needs. The network is designed to be scalable, flexible and to grow to meet future demands seamlessly.
Purification and Structure Determination of Glucosides of Capsaicin and Dihydrocapsaicin from Various <i>Capsicum </i>Fruits (2006)

Two new glucosides, capsaicin-beta-D-glucopyranoside (1) and dihydrocapsaicin-beta-D-glucopyranoside (2), were discovered in the fruit of the Capsicum annuum cultivar 'High Heat'. They were sequentially purified by acetone extraction, n-hexane extraction, and acetonitrile extraction, followed by medium-pressure liquid chromatography and high-performance liquid chromatography performed on an octadecylsilane column. Their chemical structures were elucidated by proton nuclear magnetic resonance, carbon nuclear magnetic resonance, and hydrolysis with alpha- and beta-glucosidases. The glucosides were also detected in various pungent cultivars of C. annuum, Capsicum frutescens, and Capsicum chinense by liquid chromatography-mass spectrometry. However, they were not detected in nonpungent cultivars of C. annuum. Furthermore, a positive correlation was observed between the quantity of the capsaicinoids, capsaicin, and dihydrocapsaicin and their glucosides.
Augmentation of the maxillary sinus: a surgical technique. (1997)

Specific anatomic and physiologic differences between the maxillary and mandibular arches have presented challenges in restoring the fully or partially edentulous maxilla. These differences include the quality and quantity of available bone at the potential implant site. To address the limitations of the maxillary arch, attempts have been made during the last two decades to improve implant anchorage in this area. Bone grafting techniques and guided bone regeneration have been utilized to augment and improve the maxillary arch. The learning objective of this article is to review the important aspects related to the anatomy and physiology of the maxillary sinus, to discuss the use of various grafting materials, and to describe the technique and current status of the maxillary sinus augmentation procedures. Emphasis is placed upon presentation of the presurgical, surgical, and postsurgical protocol of maxillary sinus augmentation, as performed by the authors.
Biochemical changes in the cartilage of the knee in experimental and natural osteoarthritis in the dog (1976)

Biochemical changes in the articular cartilage of the knees of mature dogs, one with natural and four with surgically induced osteoarthritis, have been investigated. The four dogs were killed three, six, nine and forty-eight weeks after division of the right anterior cruciate ligament, the left knees serving as controls. The cartilage of the joints operated on was thicker and more hydrated than the control cartilage; the proteoglycans were more easily extracted and had higher galactosamine/glucosamine molar ratios. The proportion of proteoglycans firmly associated with collagen, and hence not extractable, diminished before fibrillation was demonstrable by indian ink staining of the surface. These biochemical changes were present throughout the entire cartilage of the joints operated on of the dogs killed more than three weeks later, and of the dog with natural osteoarthritis. The results suggest that in response to altered mechanical stresses the chondrocytes synthesise proteoglycans that contain more chondroitin sulphate relative to keratin sulphate than normally, as in immature articular cartilage.
A Functional Screen Identifies Specific MicroRNAs Capable of Inhibiting Human Melanoma Cell Viability (2012)

Malignant melanoma is an aggressive form of skin cancer with poor prognosis. Despite improvements in awareness and prevention of this disease, its incidence is rapidly increasing. MicroRNAs (miRNAs) are a class of small RNA molecules that regulate cellular processes by repressing messenger RNAs (mRNAs) with partially complementary target sites. Several miRNAs have already been shown to attenuate cancer phenotypes, by limiting proliferation, invasiveness, tumor angiogenesis, and stemness. Here, we employed a genome-scale lentiviral human miRNA expression library to systematically survey which miRNAs are able to decrease A375 melanoma cell viability. We highlight the strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203. Ectopic expression of these miRNAs resulted in long-term inhibition of melanoma cell expansion, both in vitro and in vivo. We show specifically miR-16, miR-497, miR-96 and miR-182 are efficient effectors when introduced as synthetic miRNAs in several melanoma cell lines. Our study provides a comprehensive interrogation of miRNAs that interfere with melanoma cell proliferation and viability, and offers a selection of miRNAs that are especially promising candidates for application in melanoma therapy.
Kärlekens rymd. : Om skulpturen Mannen med kvinnan i famnen från 1906 av den norske skulptören Gustaf Vigeland (1994)

Karlekens rymd. : Om skulpturen Mannen med kvinnan i famnen fran 1906 av den norske skulptoren Gustaf Vigeland
Surface plasmon polarization filtering in a single mode dielectric waveguide (2005)

We demonstrate that metallic electrodes symmetrically placed about a single mode dielectric waveguide can effectively polarize the mode by excitation of surface plasmons. The transmission through the metal electrode waveguide structure is examined as a function of mode polarization and electrode spacing. It is found that modes polarized perpendicular to the metal surface can resonantly excite surface plasmons, extinguishing the mode in the waveguide core, while modes polarized parallel to metal surface only suffer mode attenuation due to the presence of the metal. The phase matching conditions for excitation of surface plasmons are examined and the polarization and insertion loss of the transmitted mode is experimentally verified.
Is Flexi-grid Needed Anymore with Spectrally Efficient Time Frequency Packing Terabit Superchannel Technology (2013)

We demonstrate that frequency packing technology breathes new life into existing optical networks by allowing terabit super-channel transport against common opinion that expensive flex-grid infrastructure upgrade is required. 4.2 to 5.69 b/s/Hz spectral efficiency is obtained over ULH reach.
Recent advances in the pathogenesis and treatment of nonimmune neutropenias in the neonate (1998)

Neutropenia in the neonate is defined as a significantly lower than normal concentration of neutrophils in the peripheral blood and can be broadly classified as immune or nonimmune. Nonimmune neutropenias are those that are not the direct or indirect result of antibodies directed against neutrophils. Recent advances have been made in the pathogenesis and treatment of several types of neonatal neutropenia, including reticular dysgenesis, Schwachman-Diamond syndrome, Kostmann syndrome, neutropenia in infants of hypertensive women, and "idiopathic neutropenia." This review of nonimmune neutropenias highlights these developments.
Targeted Delivery of MicroRNA125a-5p by Engineered Lipid Nanoparticles for the Treatment of HER2 Positive Metastatic Breast Cancer (2016)

MicroRNAs (miRNAs) are endogenous regulators of gene expression that play a pivotal role in biological processes spanning from global homeostasis to disease onset and progression. The ability to manipulate and induce cellular reequilibrium of deregulated miRNA expression profiles by inhibition of oncogenic miRNA or overexpression of tumor suppressor miRNA is a promising cancer strategy, but is currently hindered in application by the lack of nonviral delivery systems. Here we present a lipid nanoparticle (LNP) platform surface coated with Hyaluronic Acid (HA) for the delivery of mature tumor suppressor MicroRNA125a-5p to treat HER2 positive metastatic breast cancer. The delivery platform actively targets patient-derived metastatic breast cancer cells (21MT-1) isolated from the metastatic pleural effusion over normal breast tissue via an intrinsic HA-CD44 mediated endocytosis event, and has the ability to escape from the intracellular endolysosomal pathway for potent gene silencing. Knockdown of the HER2 proto-oncogene at the level of transcription and translation was achieved following HA-LNP mediated transfection with MicroRNA125a-5p. In addition, the PI3K/AKT and MAPK hyperactivated signaling pathways, cellular proliferation, and migration potential were also potently suppressed. Furthermore, the therapeutic efficacy of MicroRNA125a-5p by the HA-LNP platform was demonstrated to be significantly improved as compared to a commercial transfection reagent. This study highlights the therapeutic potential of MicroRNA125a-5p as a standalone treatment of HER2+ metastatic breast cancer via a translational nonviral delivery platform. These findings have major implications on future gene therapy regimens for breast cancer.
An alignment-capable microplanner for natural language generation (2009)

Alignment of interlocutors is a well known psycholinguistic phenomenon of great relevance for dialogue systems in general and natural language generation in particular. In this paper, we present the alignment-capable microplanner SPUD prime. Using a priming-based model of interactive alignment, it is flexible enough to model the alignment behaviour of human speakers to a high degree. This will allow for further investigation of which parameters are important to model alignment and how the human--computer interaction changes when the computer aligns to its users.
A reconfigurable video embedding transcoder based on H.264/AVC: Design tradeoffs and analysis (2008)

In this paper, we propose a system architecture for H.264/AVC video embedding transcoder (VET). In addition, the proposed platform-based design can seamlessly combine the MW-VET and decoder such that it can be dynamically configured to perform video decoding and transcoding alternatively or simultaneously. Furthermore, we perform the pruned design space exploration on the design of inter/intea prediction and the on-chip data bus width. Our proposed architecture provides a better tradeoff among execution cycles, hardware cost, resource utilization, and video quality because of the reconfigurable processing modules and the hybrid pipelining. As compared to the cascaded pixel domain transcoder that has the highest complexity, our hardware efficient VET can significantly reduce the hardware cost while maintaining similar rate-distortion performance. Finally, the proposed architecture is verified at system level using transaction level modeling (TLM) technique. From the simulation results, the proposed architecture with the best tradeoff configuration can achieve a transcoding rate up to 358 frames per second for SD video source while clocking at 162MHz.
The identification of bacillaene, the product of the PksX megacomplex in <i>Bacillus subtilis</i> (2007)

The approximately 80-kb pksX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/nonribosomal peptide synthase that has been linked to the production of the uncharacterized antibiotic bacillaene. Multiple copies of this synthase, each similar in size to the ribosome, assemble into a single organelle-like complex with a mass of tens to hundreds of megadaltons. The resource requirements of the assembled megacomplex suggest that bacillaene has an important biological role. By coupling a differential NMR spectroscopic technique with genetically manipulated strains of B. subtilis, we were able to characterize the structure of this unusual secondary metabolite, which could not be predicted by using bioinformatic analysis. We report that bacillaene is a linear molecule with two amide bonds: the first links an alpha-hydroxy carboxylic acid to a omega-amino carboxylic acid containing a conjugated hexaene, and the second links the hexaene-containing carboxylic acid to an (omega-1) amino carboxylic acid containing a conjugated triene. Knowledge of bacillaene's structure has enabled us to annotate the pksX gene cluster and should facilitate the study of bacillaene's biosynthesis as well as its biological role in B. subtilis.
Thermal independent Silicon-Nitride slot waveguide biosensor with high sensitivity (2012)

As the sensitivity and detection limit of photonic refractive index (RI) biosensor increases, the temperature dependence becomes a major challenge. In this paper, we present a Mach-Zehnder Interferometer (MZI) biosensor based on silicon nitride slot waveguides. The biosensor is designed for minimal temperature dependence without compromising the performance in terms of sensitivity and detection limit. With air cladding, the measured surface sensitivity and detection limit of MZI biosensor reach 7.16 nm/(ng mm(-2)) and 1.30 (pg mm(-2)), while achieving a low temperature dependence is 5.0 pm/° C. With water cladding, the measured bulk sensitivity and detection limit reach 1730(2π)/RIU and 1.29 × 10(-5) RIU respectively. By utilizing Vernier effect through cascaded MZI structures, the measured sensitivity enhancement factor is 8.38, which results in a surface detection limit of 0.155 (pg mm(-2)).
Functional gastrointestinal disorders as a public health problem (2008)

The functional gastrointestinal disorders (FGIDs) are a heterogeneous group of chronic conditions that are considered to be important to public health because they are remarkably common, can be disabling, and induce a major social and economic burden. Despite the Rome consensus process, the line defining true abnormality from health is as yet imprecise. Furthermore, the concept that the FGIDs have no pathological or biochemical correlates is starting to unravel, and some candidate morphometric abnormalities (e.g. duodenal eosinophilia, colonic mastocytosis) have been documented. The quality of care that patients with FGIDs receive is not well understood, despite the high volume of patients seen in primary and specialty care. There are a remarkable number of symptom-based and disease-based co-morbidities that appear to be more common in those with FGIDs that are not alone explained by coexistent somatization. Whether there is any means of preventing the development of FGIDs post-infection is untested but has vast public health implications. Defining disease severity remains key to better understanding the public health impact of FGIDs; severity is probably influenced by the intestinal and extra-intestinal symptom burden, psychological distress and the impact on quality of life, but how these factors interact remains uncertain. An important future research direction must be to quantify at what risk level it is reasonable to prescribe a medication that may be dangerous, and stratify which subsets of patients with FGIDs would qualify for such an approach using objective well validated tools (e.g. based on accurately defining gradations of severity of disease). Finally, there are some reasons to suspect that there may be an increase in mortality in FGID sufferers; for example, unnecessary surgery or invasive testing has a small but not zero associated mortality, and this should be a factor in view of the high prevalence of disease.