gebhart/patrepeval huggingface dataset:
Rat secretory component binds poorly to rodent IgM (1992)

Abstract Our previous studies and those of others indicated that human secretory component (SC), the five domain extracellular portion of the poly Ig receptor, binds avidly to both pIgA and IgM. In this study we report that in rodents, SC binds primarily to pIgA. Rat secretory component was isolated from bile and radiolabeled to known specific activity with 125I. Radiolabeled rat SC was incubated with rat and mouse monoclonal proteins for 1 h at room temperature and overnight at 4 degrees D. Binding of 125I-rat SC to Ig was determined in two ways: 1) immunoprecipitation of putative 125I-rat SC-Ig complexes with anti-L chain antibodies; 2) HPLC gel filtration on an analytical TSK 4000 column that separated free 125I-rat SC from 125I-rat SC bound to Ig. Both methods of analysis yielded similar results. Rat and mouse polymeric (p) IgA bound rat SC with high avidity, although the binding activity of the IgM from either species was virtually nil. The number of SC-binding sites on rat polymeric Ig was determined by immunoprecipitation of mixtures of rat pIg with saturating concentrations of 125I-rat SC and yielded values of 1.0 and 0.05 for rat pIgA and IgM, respectively. The significance of these findings with respect to the biologic function of the pIg R in rodents and the nature of the pIg R-binding site on pIg is discussed.
RESISTANCE OF METAL COMPLEXES OF CONALBUMIN AND TRANSFERRIN TO PROTEOLYSIS AND TO THERMAL DENATURATION (1958)

In the present study, a much greater stability of the metal complexes of both conalbumin and transferrin was encountered than had apparently been suspected heretofore. This report concerns the relative stabilities of these proteins and their metal complexes to enzyme action and to thermal denaturation.
Can Prophylactic Application of Immunoglobulin Decrease Radiotherapy-Induced Oral Mucositis? (1997)

Therapeutic application of immunoglobulin is reported to be successful in radiation-induced oral and oropharyngeal mucositis. In this study the efficacy of prophylactic application of immunoglobulin was investigated. In 42 patients with head and neck cancer, postoperative radiation treatment or radiation combined with chemotherapy was performed. In 20 consecutive patients, prophylactic mucositis treatment consisted of panthenol (4 x 10 ml/day) and nystatin (4 x 1 ml/day). The 22 following patients received, supplementary to panthenol and nystatin, 800 mg (5 ml) human immunoglobulin intramuscularly once weekly. During the treatment time, the degree of mucositis was examined 3 times a week. The distribution of maximal mucositis degree revealed slightly more severe mucous membrane reaction in the control group compared with the immunoglobulin group (n.s.). The analysis of mean mucositis degrees in both groups demonstrated statistically significant differences (t test, p = 0.031) related to the entire group (n = 42) and to those 16 patients receiving radiation combined with chemotherapy. There was no significant immunoglobulin-induced effect on mucositis in patients treated by radiation alone. The time from the beginning of therapy to the first interruption could be prolonged 5 days in the immunoglobulin group (n.s.). In conclusion, it is demonstrated that the prophylactic application of immunoglobulin seems to lower the degree of radiation-induced mucositis. In comparison to the published data about therapeutically given immunoglobulin, the clinical efficacy of the prophylactic application of immunoglobulin as it is performed in this study is less evident.
Ambivalent bacteriophages of different species active on Escherichia coli K12 and Salmonella sp. strains (2006)

A study was made of several bacteriophages (including phages U2 and LB related to T-even phages of Escherichia coli) that grow both on E. coli K12 and on some Salmonella strains. Such phages were termed ambivalent. T-even ambivalent phages (U2 and LB) are rare and have a limited number of hosts among Salmonella strains. U2 and LB are similar to canonical E. coli-specific T-even phages in morphological type and size of the phage particle and in reaction with specific anti-T4 serum. Phages U2 and LB have identical sets of structural proteins, some of which are similar in size to structural proteins of phages T2 and T4. DNA restriction patterns of phages U2 and LB differ from each other and from those of T2 and T4. Still, DNAs of all four phages have considerable homology. Unexpectedly, phages U2 and LB grown on Salmonella bungori were unstable during centrifugation in a CsCl gradient. Ambivalent bacteriophages were found in species other than T-even phages and were similar in morphotype to lambdoid and other E. coli phages. One of the ambivalent phages was highly similar to well-known Felix01, which is specific for Salmonella. Ambivalent phages can be used to develop a new set for phage typing in Salmonella. An obvious advantage is that ambivalent phages can be reproduced in the E. coli K12 laboratory strain, which does not produce active temperate phages. Consequently, the resulting typing phage preparation is devoid of an admixture of temperate phages, which are common in Salmonella. The presence of temperate phages in phage-typing preparations may cause false-positive results in identifying specific Salmonella strains isolated from the environment or salmonellosis patients. Ambivalent phages are potentially useful for phage therapy and prevention of salmonellosis in humans and animals.
All-inkjet-printed, solid-state flexible supercapacitors on paper (2016)

All-inkjet-printed, solid-state flexible supercapacitors (SCs) on paper are demonstrated as a new class of power sources with exceptionally versatile aesthetics. The inkjet-printed SCs look like inkjet-printed letters or figures commonly found in office documents and are aesthetically unitized with other printed images on paper.
Stem cells in the mammalian eye: a tool for retinal repair (2005)

Degenerative diseases and traumatic injuries of the central nervous system (CNS) are major causes of long-term disability, whether such insults impact the brain, retina, or spinal cord. Substantial tissue destruction can be sustained by these complex structures without loss of life, while the lack of effective CNS regeneration frequently results in a marked degradation in quality of life. Only recently has it become clear that an enormous potential for regeneration is present within the mammalian CNS. The challenge now presented to researchers is to harness this potential to treat disease. Recent studies showing that stem and progenitor cells can be isolated from the mammalian retina have prompted many researchers to develop strategies aimed at restoring function to the diseased retina. This review summarizes a number of issues related to this goal, including retinal development, transplantation immunology, tissue engineering, and large animal studies. The application of these divergent disciplines to stem cell technology is vital to the development of the novel strategies needed to make retinal transplantation a clinical success.
Inorganic nitrate and nitrite and control of blood pressure (2010)

Continual nitric oxide (NO) synthesis is important in the regulation of vascular tone and thus blood pressure. Whereas classically NO is provided by the enzymatic oxidation of l-arginine via endothelial NO synthase, it is now clear that NO can also be generated in mammals from the reduction of nitrite and nitrate. Thus inorganic nitrate derived either from NO oxidation or from dietary sources may be an important storage form of reactive nitrogen oxides which can be reduced back to nitrite and NO when physiologically required or in pathological conditions. The very short half-life of NO and the ready availability of stored nitrite and nitrate make for a very sensitive and responsive blood pressure control system. This review will examine processes by which these storage forms are produced and how augmentation of dietary nitrate intake may have a beneficial effect on blood pressure and other vascular function in humans.
Predictive and Concurrent Validity of Standardized Neurodevelopmental Examinations by the Griffiths Scales and Bayley Scales of Infant Development II (2012)

Standardized examinations of preterm infants are used to identify candidates for early intervention. We aimed to assess the predictive power and concurrent validity of the mental development index of the Bayley scales of infant development II (Bayley MDI) and the Griffiths scales developmental quotient (Griffiths DQ) in healthy term and preterm infants <1500 g birth weight without major perinatal complications.137 Infants (89 term, 48 preterm) were examined by both tests at a corrected age of 6, 12, and 22 months, and 114 went on to undergo Bayley assessments at 39 months.There were significant correlations between Bayley and Griffiths results at 6, 12, and 22 months (r=0.530, 0.714, and 0.833, respectively, p<0.001) but Bland Altman plots revealed major systematic bias at 6 months (Griffiths>Bayley, mean differences 14.3±9.8) and 22 months (Bayley>Griffiths, mean difference 5.2±13.9) and wide 95% limits of agreement at 6, 12 and 22 months (35.9%, 40.0%, and 52.4%, respectively). The agreement for a presumptive diagnosis of developmental impairment in the group of preterm infants between Bayley examinations obtained at 39 months corrected age (reference) and previous examinations was poor at 6, 12, and 22 months for both Bayley and Griffiths (Cohen's kappa for Griffiths: 0.225, 0.192, 0.369; for Bayley: 0.121, 0.316, 0.369, respectively).Caution should be exercised when interpreting results from standardized neurodevelopmental examinations obtained during the first 2 years of life in comparatively well preterm infants.
A hierarchical method for aligning warped meshes (2004)

Current alignment algorithms for registering range data captured from a 3D scanner assume that the range data depicts identical geometry taken from different views. However, in the presence of scanner calibration errors, the data will be slightly warped. These warps often cause current alignment algorithms to converge slowly, find the wrong alignment, or even diverge. We present a method for aligning warped range data represented by polygon meshes. Our strategy can be characterized as a coarse-to-fine hierarchical approach, where we assume that since the warp is global, we can compensate for it by treating each mesh as a collection of smaller piecewise rigid sections, which can translate and rotate with respect to each other. We split the meshes subject to several constraints, in order to ensure that the resulting sections converge reliably.
Simultaneous and Group-Sparse Multi-Task Learning of Gaussian Graphical Models (2012)

In this paper, we present `1,p multi-task structure learning for Gaussian graphical models. We discuss the uniqueness and boundedness of the optimal solution of the max-imization problem. A block coordinate descent method leads to a provably convergent algorithm that generates a sequence of positive definite solutions. Thus, we reduce the original problem into a sequence of strictly convex `p regularized quadratic minimization subproblems. We further show that this subproblem leads to the continuous quadratic knapsack problem for p = ∞ and to a separable version of the well-known quadratic trust-region problem for p = 2, for which very efficient methods exist. Finally, we show promising results in synthetic experiments as well as in two real-world datasets. 1
A DSP core for speech coding applications (2002)

An application specific processor core for mobile speech coding applications has been designed and implemented. Since the architecture is tailored to the application, it has a very low power consumption, making it attractive for handheld devices. The low power consumption, flexible design and high performance have been achieved by a standby mode, optimized full custom design, and a low clock frequency, together with a highly parallel architecture. All the parallelism is accessible to the user on the assembler level. Engineering samples of the processor have been fabricated and tested. The silicon area required for the core is approximately 25 mm/sup 2/ using 1.0 /spl mu/m CMOS. A typical average power consumption for a GSM full rate speech codec implementation using this core is less than 50 mW at 5 V operating voltage, and the complex algorithm is executed in less than 5 ms for each 20 ms speech frame (including encode, decode, VAD and DTX operations).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Anti-neurofilament antibodies in slow infections of the nervous system]. (1988)

Twenty-six patients including 12 with lateral amyotrophic sclerosis, 7 with multiple sclerosis, 5 with the Creutzfeld-Jakob disease and 2 with Alzheimer's disease were examined. Antibodies to neurofilaments in the blood serum were detected in all cases of the Creutzfeld-Jakob disease and Alzheimer's disease and in 8 patients with lateral amyotrophic sclerosis with clinical evidence of supranuclear structure involvement. A conclusion is drawn about a certain similarity of pathogenic mechanisms of these diseases, as well as about heterogeneity of the cytoskeleton of neurons in the brain and the spinal cord.
Pilot Plant Preparation of an α<sub>v</sub>β<sub>3</sub> Integrin Antagonist. Part 1. Process Research and Development of a (<i>S</i>)-β-Amino Acid Ester Intermediate:  Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction (2003)

Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key intermediate to the αvβ3 integrin antagonist 1. Reported are an asymmetric Michael reaction approach, attempts to enantioselectively hydrogenate an enamine, resolution of (±)-3 via diastereomeric salt formation, and a synthetic route employing a novel, diastereoselective imino-Reformatsky reaction. This last research initiative proved successful and was employed as the enabling route to initial API supply. Process development of this enabling chemistry is reported. The technical issues researched and optimized were (1) the necessity of employing MEM-protection for high yield and diastereoselectivity in the imino-Reformatsky reaction, (2) the reaction kinetics of MEM chloride hydrolysis and the application of these data to an on-scale quench procedure, (3) the efficient formation of the (S)-phenylglycinol imine 15 in NMP and a dehydration of this product solution on-scale, employing molecular sieves, (4) a calorimetric study of the Reformatsky reaction and the application of these data, (5) the replacement of Pb(OAc)4 with NaIO4 and the use of methylamine to sequester competing oxazolidine formation, and (6) further development of the isolation and purification protocol for the ethyl ester, p-TsOH salt of (S)-3. The results and challenges associated with two campaigns in which the potential commercial process was practiced are discussed.
The Oxford Clay of Skye, Scalpay and Eigg (1966)

Synopsis Callovian and Oxfordian rocks outcrop on the Inner Hebridean Islands of Skye, Scalpay and Eigg. The Callovian and Lower Oxfordian argillaceous beds in Staffin Bay are described. The deposits are fossiliferous and include all zones from the Jason Zone of the Middle Callovian to the Plicatilis Zone of the Middle Oxfordian. In Strathaird the lowest proved zone is of Lamberti or possibly Upper Athleta Zone age. In Strathaird, on Scalpay and in Staffin Bay the succession reaches the Upper Oxfordian, while even higher beds occur in Staffin Bay and on Mull. The name Staffin Shales is proposed for the fine-grained sediments of North Skye.
CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project (2002)

CDT was little better than GGT in detecting high- or intermediate-risk alcohol consumption in this large, multicenter, predominantly community-based sample. As the two tests are relatively independent of each other, their combination is likely to provide better performance than either test alone. Test interpretation should take account sex, age, and body mass index.
Economic Evolution from EPON to WDM-overlaid PON Employing a Wavelength Conversion Node (2007)

Cost-effective evolution architecture from EPON to WDM-overlaid PON is proposed. To maintain the colorless characteristics of ONUs, a wavelength-conversion node is employed. Appropriate structures for a remote node and a WCN are suggested and analyzed.
Differential Distribution of Immature Ixodes dammini (Acari: Ixodidae) on Rodent Hosts (1989)

Ectoparasites such as ixodid ticks that remain attached to hosts for several days while feeding on blood are able to overcome the inflammatory and immune responses of some hosts and not others. The immature stages of the deer tick Ixodes dammini are found more frequently on the white-footed mouse, Peromyscus leucopus, than on other rodents. We propose that P. leucopus is more tolerant to I. dammini than is a less common host, the meadow vole, Microtus pennsylvanicus. To test this hypothesis, the distribution patterns and engorgement indices were determined for larval and nymphal I. dammini collected from wild-caught P. leucopus and M. pennsylvanicus. There were more immature ticks, which were more fully engorged, on P. leucopus than on M. pennsylvanicus. There were more and better engorged ticks on male than on female hosts. Laboratory studies on the number and weights of larval I. dammini collected off naive and previously exposed P. leucopus and M. pennsylvanicus support the results of the field study. Fewer larval ticks were recovered from previously exposed M. pennsylvanicus than P. leucopus, and the ticks weighed less. Larval and nymphal ticks aggregated among hosts in the study grid, and higher densities per male P. leucopus were correlated with higher engorgement indices, suggesting that immature I. dammini feed better at higher densities. The feeding success of I. dammini on its preferred host species might be due to its adaptation to the immune and inflammatory reactions of the host.
Ferroelectricity in HfO<sub>2</sub> enables nonvolatile data storage in 28 nm HKMG (2012)

We report on the most aggressively scaled ferroelectric field effect transistor so far. These were successfully fabricated using ferroelectric Si:HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> in a 28 nm HKMG stack (TiN/Si:HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Si). For a ± 5 V program/erase operation with pulses as short as 20 ns, reliable threshold voltage shifts were observed resulting in a memory window of about 0.9 V. We further demonstrate endurance characteristics matching demands of current nonvolatile memories utilizing wear leveling. Low retention loss was observed and extrapolated 10-year data storage can be expected.
Amiodarone Has Intrinsic Anti-<i>Trypanosoma </i><i>c</i><i>ruzi</i> Activity and Acts Synergistically with Posaconazole (2006)

There is no effective treatment for the prevalent chronic form of Chagas' disease in Latin America. Its causative agent, the protozoan parasite Trypanosoma cruzi, has an essential requirement for ergosterol, and ergosterol biosynthesis inhibitors, such as the antifungal drug posaconazole, have potent trypanocidal activity. The antiarrhythmic compound amiodarone, frequently prescribed for the symptomatic treatment of Chagas' disease patients, has also recently been shown to have antifungal activity. We now show here for the first time that amiodarone has direct activity against T. cruzi, both in vitro and in vivo, and that it acts synergistically with posaconazole. We found that amiodarone, in addition to disrupting the parasites' Ca(2+) homeostasis, also blocks ergosterol biosynthesis, and that posaconazole also affects Ca(2+) homeostasis. These results provide logical explanations for the synergistic activity of amiodarone with azoles against T. cruzi and open up the possibility of novel, combination therapy approaches to the treatment of Chagas' disease using currently approved drugs.
Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long‐term serial adipose tissue–derived mesenchymal stem cell transplantation (2011)

Serial human AD-MSC transplantation had beneficial effects in the treatment of SLE, without adverse effects. Transplantation of human AD-MSCs before disease onset was preferable for amelioration of SLE and restoration of immune homeostasis.
A Histologic Basis for the Efficacy of SBRT to the lung (2016)

Our results demonstrate an increased rate of local failure in patients with squamous cell carcinoma. Standard approaches for radiotherapy that demonstrate efficacy for a population may not achieve optimal results for individual patients. Establishing the differential dose effect of SBRT across histological groups is likely to improve efficacy and inform ongoing and future studies that aim to expand indications for SBRT.
Characterization and Simulation of a 915MHz Wireless Receiver (1997)

A versatile test bench and CAE environment are employed to characterize and simulate a 915MHz receiver subsystem. The subsystem, which down-converts to a 70MHz IF frequency, is constructed with coaxial components and characterized at several different levels. The 3GHz test bench used includes a vector network analyzer, a spectrum analyzer, and a synthesized signal source. Measurements are compared to system simulations enabled by HP EEsof's Series IV: Communications Design Suite™ (CDS). Simulation accuracy is improved through the use of measured component level characterization data. This receiver case study provides powerful insight into the capabilities of modern measurement and simulation tools for assessment of system-level linear and non-linear performance. The revealing case study, developed for a new undergraduate course in Wireless Circuits and Systems, would be easily duplicated for in-house company training, short course seminars, as well as RF/microwave courses at other universities.
Nematicidal Activity of Monoterpenoids Against the Root-Knot Nematode <i>Meloidogyne incognita</i> (2010)

ABSTRACT Nematicidal activity of 22 monoterpenoids were evaluated in vitro and in pot experiments. Twenty of the twenty-two monoterpenoids significantly reduced hatching, and 11 reduced J2 mobility of the root-knot nematode Meloidogyne incognita at a concentration of 250 mg/liter. In general, compounds with hydroxyl and carbonyl groups exhibited higher nematicidal activity than other terpenoids. Borneol, carveol, citral, geraniol, and alpha-terpineol showed the highest nematicidal activity among the in vitro tested monoterpenoids. These compounds exhibited a dose dependent effect, and drastically reduced eggs hatching and J2 viability at low concentrations. These monoterpenoids, at 100 and 250 mg/kg concentration, diminished root galling of tomato plants in pot experiments. The results suggest that the selected monoterpenoids, and essential oils with high concentration of these compounds, are potential nematicides against Meloidogyne.