gebhart/patrepeval huggingface dataset:
Molecular beam epitaxial growth of metamorphic AlInSb/GaInSb high-electron-mobility-transistor structures on GaAs substrates for low power and high frequency applications (2011)

We report on molecular beam epitaxial growth of AlInSb/GaInSb metamorphic high-electron-mobility-transistor structures for low power, high frequency applications on 4 in. GaAs substrates. The structures consist of a Ga0.4In0.6Sb channel embedded in Al0.4In0.6Sb barrier layers which are grown on top of an insulating metamorphic buffer, which is based on the linear exchange of Ga versus In and a subsequent exchange of As versus Sb. Precise control of group V fluxes and substrate temperature in the Al0.4In0.6As1−xSbx buffer is essential to achieve high quality device structures. Good morphological properties were achieved demonstrated by the appearance of crosshatching and root mean square roughness values of 2.0 nm. Buffer isolation is found to be &gt;100 kΩ/◻ for optimized growth conditions. Hall measurements at room temperature reveal electron densities of 2.8×1012 cm−2 in the channel at mobility values of 21.000 cm2/V s for single-sided Te volume doping and 5.4×1012 cm−2 and 17.000 cm2/V s for double-sided Te δ-doping, respectively.
Externally Activated Antitachycardia Pacemaker With Noninvasive Electrophysiologic Re‐testing Capability (1985)

An Omni Orthocor 234A special device pacemaker was implanted in nine patients for treatment of drug-resistant supraventricular tachycardia (three patients) or ventricular tachycardia (six patients). This device is activated using a special external unit, which delivers from six to 15 stimuli at preselected coupling intervals ranging from 195 to 500 ms. Serial noninvasive electrophysiology studies were performed either in the hospital or on an outpatient basis using the triggered mode, which can respond to programmed chest wall stimulation. Three patients with reciprocating supraventricular tachycardia were treated effectively by this device during an average follow-up of 2.2 years. Of the six patients with stable ventricular tachycardia amenable to pacemaker termination, only four remained successful during an average follow-up of 1.9 years. Such devices may find important use in serial noninvasive electrophysiologic testing during long-term clinical follow-up. The present form of this device is inadequate for widespread application, but may be useful for highly selected individuals.
Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis (1995)

To demonstrate that the lipid volume fraction in liver steatosis can be accurately estimated with in vivo hydrogen-1 magnetic resonance (MR) spectroscopy, the authors developed a calibration procedure based on in vitro MR spectroscopy of lipid extracts from steatotic liver specimens. The lipid volume fractions determined with the calibration procedure were compared with the results of histomorphometry and with calibrated computed tomographic (CT) data. The volume fraction of fat determined with MR spectroscopy was in good agreement with the CT results, whereas histomorphometry underestimated the amount of hepatic fat. The results indicate that determination of the fat volume fraction in steatotic liver can be achieved noninvasively with MR spectroscopy.
1&#x00D7;8 Si ring Mux/DeMux with ultra-low tuning power (2013)

We report a compact 1×8 silicon Mux/DeMux with ring tuning efficiency of <;3μW/GHz using back-side substrate removal technique. Total power of <;4.1mW was measured to tune the device to a 1.6nm wavelength grid.
Interactive collaborative production scheduling (2002)

Most currently implemented production scheduling technologies are fully automated in powerful intelligent computer systems, controlled and operated by highly skilled planning staff. In this paper we present an alternative solution to scheduling, which involves the people that are usually being scheduled. The model we present, allows teams of production workers to schedule their own work. This scheduling activity is still supported by intelligent systems that consider all possible constraints and suggest alternatives to the teams, but the teams take the final scheduling decisions themselves.
Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis (1997)

Among the many genes which have been suggested to be required by the molecular mechanism dictating apoptotic death, some have been shown to function as pacemakers to pave the way for cells either to liver or to die. Previously we have shown that immediate early gene expression associated with the G1 phase of cell cycle traverse are candidates for this function. Here we report that well-known key regulator for halting cell cycling at the G1/S border, the p21 protein known as WAF1, Cip1, Pic1, or Sdi1, is also involved in the execution of cells' suicidal death. p21 up-regulation is seen in quiescent mouse 3T3 fibroblasts stimulated to die by serum deprivation, at both message and protein levels, evidenced by increased protein presence in its targeted functional site, the nucleus. In addition, we show that this up-regulation of p21 is functionally related to the operational efficiency of the apoptotic process, in that when cells are stably transfected with an antisense construct to repress the endogenous p21-protein level, death is delayed. Quantitative protection from apoptosis with antisense p21 transfection is relatively proportional to the repressed level of this protein in the cells. Taken together, our results suggest that the apoptotic-dependent additional increase of p21 beyond the base level, seen in serum-deprived quiescent cells, may be involved in the molecular events precipitating a rapid program of cell demise, and that repression of this increase may obstruct the operation of this program and postpone the eventual death.
Control of Shroud Leakage Loss by Reducing Circumferential Mixing (2008)

Shroud leakage flow undergoes little change in the tangential velocity as it passes over the shroud. Mixing due to the difference in tangential velocity between the main stream flow and the leakage flow creates a significant proportion of the total loss associated with shroud leakage flow. The unturned leakage flow also causes negative incidence and intensifies the secondary flows in the downstream blade row. This paper describes the experimental results of a concept to turn the rotor shroud leakage flow in the direction of the main blade passage flow in order to reduce the aerodynamic mixing losses. A three-stage air model turbine with low aspect ratio blading was used in this study. A series of different stationary turning vane geometries placed into the rotor shroud exit cavity downstream of each rotor blade row was tested. A significant improvement in flow angle and loss in the downstream stator blade rows was measured together with an increase in turbine brake efficiency of 0.4 %.
Virulence factors (aerobactin and mucoid phenotype) in<i>Klebsiella pneumoniae</i>and<i>Escherichia coli</i>blood culture isolates (1995)

We examined the presence of two virulence factors in 241 blood isolates of Klebsiella pneumoniae from patients hospitalized during 1989 and 1990 in 7 French hospitals, and 125 blood isolates of Escherichia coli from one hospital. Aerobactin was scored phenotypically and genotypically with an intragenic DNA probe of 2 kb. The mucoid phenotype was assessed by culture on trypticase soy agar and by genotypic analysis (intragenic DNA probe of 235 bp). Only 6%K. pneumoniae isolates were aerobactin-positive with no significant variation according to geographical location while 20% of K. pneumoniae isolates displayed the mucoid phenotype, with a significant variation according to hospital. Aerobactin was always associated with the mucoid phenotype. The frequency of aerobactin production but not mucoid phenotype (14%) was higher among E. coli isolates (48%). They harbored two types of large plasmids. Intraperitoneal injection into mice of 103 cfu of K. pneumoniae producing both virulence factors demonstrated that capsular serotype K2 was the more virulent K23 and K28.
A New Series of <i>N</i>-[2,4-Dioxo-6-<scp>d</scp>-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase:  Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications (2008)

The penultimate step in the biosynthesis of riboflavin is catalyzed by lumazine synthase. Three metabolically stable analogues of the hypothetical intermediate proposed to arise after phosphate elimination in the lumazine synthase-catalyzed reaction were synthesized and evaluated as lumazine synthase inhibitors. All three intermediate analogues were inhibitors of Mycobacterium tuberculosis lumazine synthase, Bacillus subtilis lumazine synthase, and Schizosaccharomyces pombe lumazine synthase, while one of them proved to be an extremely potent inhibitor of Escherichia coli riboflavin synthase with a Ki of 1.3 nM. The crystal structure of M. tuberculosis lumazine synthase in complex with one of the inhibitors provides a model of the conformation of the intermediate occurring immediately after phosphate elimination, supporting a mechanism in which phosphate elimination occurs before a conformational change of the Schiff base intermediate toward a cyclic structure.
Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction (2013)

MCL-1 is an essential BCL-2 family member that promotes the survival of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we report that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy manifested by a loss of cardiac contractility, abnormal mitochondria ultrastructure, and defective mitochondrial respiration. Strikingly, genetic ablation of both proapoptotic effectors (Bax and Bak) could largely rescue the lethality and impaired cardiac function induced by Mcl-1 deletion. However, while the overt consequences of Mcl-1 loss were obviated by combining with the loss of Bax and Bak, mitochondria from the Mcl-1-, Bax-, and Bak-deficient hearts still revealed mitochondrial ultrastructural abnormalities and displayed deficient mitochondrial respiration. Together, these data indicate that merely blocking cell death is insufficient to completely overcome the need for MCL-1 function in cardiomyocytes and suggest that in cardiac muscle, MCL-1 also facilitates normal mitochondrial function. These findings are important, as specific MCL-1-inhibiting therapeutics are being proposed to treat cancer cells and may result in unexpected cardiac toxicity.
Reference Chart Derived From Post–Stent-Implantation Intravascular Ultrasound Predictors of 6-Month Expected Restenosis on Quantitative Coronary Angiography (1999)

The expected 6-month in-stent restenosis rate after stent implantation for short lesions in relatively large vessels can be predicted by use of in-stent minimal area (which is inversely related to restenosis) and stent length (which is directly related to restenosis), both of which can be read from a simple reference chart.
A Technique for Test Coverage Closure Using GoldMine (2012)

We propose a methodology to generate input stimulus to achieve coverage closure using GoldMine, an automatic assertion generation engine that uses data mining and formal verification. GoldMine mines the simulation traces of a behavioral register transfer level (RTL) design using a decision tree based learning algorithm to produce candidate assertions. These candidate assertions are passed to a formal verification engine. If a candidate assertion is false, a counterexample trace is generated. In this paper, we feed these counterexample traces to iteratively refine the original simulation trace data. We introduce an incremental decision tree to mine the new traces in each iteration. The algorithm converges when all the candidate assertions are true. We formally prove that our algorithm will always converge and capture the complete functionality of each output of a sequential design on convergence. We show that our method always results in a monotonic increase in simulation coverage. We also present an output-centric notion of coverage, and argue that we can attain coverage closure with respect to this notion of coverage. We elaborate the technique step by step using a nontrivial arbiter design. Experimental results to validate our arguments are presented on several designs from Rigel, OpenRisc, and SpaceWire. Some practical limitations to achieve 100% coverage and the differences between final decision tree and binary decision diagram are discussed.
An overview of hydraulic fracturing and other formation stimulation technologies for shale gas production - Update 2015 (2015)

The technology of hydraulic fracturing for hydrocarbon well stimulation is not new, but only fairly recently has become a very common and widespread technique, especially in North America, due to technological advances that have allowed extracting natural gas from so-called unconventional reservoirs (tight sands, coal beds and shale formations). The conjunction of techniques such as directional drilling, high volume fracturing, micro-seismic monitoring, etc. with the development of multi-well pads has been especially successful in the last years in their application to shales, making gas production from shales technically and economically feasible. \nIn Europe, the potential application of this technology has led to both great worries and high expectations: worries regarding the alleged magnitude of the environmental impact, and expectations about production of indigenous hydrocarbons. Other types of formation stimulation exist that do not make use of water-based fluids (for instance, explosive fracturing, dynamic loading, etc.), or that make use of fluids other than water. These are currently not extensively applied due to performance considerations. \nAs for any other industrial activity, the deployment of high-volume hydraulic fracturing could potentially entail some risks to the environment. Among the concerns raised are high usage of water, methane infiltration in aquifers, aquifer contamination, extended surface footprint, induced local seismicity, etc. New technologies could help addressing these concerns (for instance by using non-toxic chemicals, by reducing or eliminating altogether the usage of water, by considerably reducing the surface footprint of a well, etc.).\nThis report is an update of the original study carried out in 2013 (2013). It reviews the latest trends in hydraulic fracturing and alternative fracturing technologies, by searching the open literature, patent databases and commercial websites (mainly in the English language). For each identified technique, an overview is given. The technique is then briefly explained, and its rationale (reasons for use) is identified. Potential advantages and disadvantages are identified, and some considerations on costs are given. Finally, the status of the technique (for instance, commercially applied, being developed, concept, etc.) is given for its application to shale gas production.
Conservative site-specific and single-copy transgenesis in human<i>LINE-1</i>elements (2015)

Genome engineering of human cells plays an important role in biotechnology and molecular medicine. In particular, insertions of functional multi-transgene cassettes into suitable endogenous sequences will lead to novel applications. Although several tools have been exploited in this context, safety issues such as cytotoxicity, insertional mutagenesis and off-target cleavage together with limitations in cargo size/expression often compromise utility. Phage λ integrase (Int) is a transgenesis tool that mediates conservative site-specific integration of 48 kb DNA into a safe harbor site of the bacterial genome. Here, we show that an Int variant precisely recombines large episomes into a sequence, term edattH4X, found in 1000 human Long INterspersed Elements-1 (LINE-1). We demonstrate single-copy transgenesis through attH4X-targeting in various cell lines including hESCs, with the flexibility of selecting clones according to transgene performance and downstream applications. This is exemplified with pluripotency reporter cassettes and constitutively expressed payloads that remain functional in LINE1-targeted hESCs and differentiated progenies. Furthermore, LINE-1 targeting does not induce DNA damage-response or chromosomal aberrations, and neither global nor localized endogenous gene expression is substantially affected. Hence, this simple transgene addition tool should become particularly useful for applications that require engineering of the human genome with multi-transgenes.
A generalizable architecture for building intelligent tutoring systems (2002)

Summary form only given. HYDRIVE (HYDRaulics Interactive Video Experience) is an intelligent tutoring system incorporating assessment as part of the tutoring process. HYDRIVE departs from typical intelligent tutoring systems in that its underlying architecture is domain independent. The domain that is presently supported by HYDRIVE is troubleshooting for the hydraulics supported systems of an Air Force F-15 fighter aircraft. HYDRIVE addresses both system-specific and system-independent skills. Several novel approaches to intelligent tutoring underlie the rationale for HYDRIVE. The reasoning component of the system makes extensive use of a hierarchical knowledge representation. Reasoning within the system is accomplished using a logic-based approach and is linked to a highly interactive interface using multimedia.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Study on Governance of Urban Renewal in the UK, Hong Kong and China: the Way to Sustainability (2016)

China’s fast growth of economy and urbanization has created a world record on its own since its reform and opening-up policy in late 1970s. This drives mass demolition and reconstruction and leaves a short lifespan of existing buildings through unsustainable urban renewal. Many developed countries/regions, such as the UK and Hong Kong, have long history of urban renewal. The urban renewal governance has shifted from government-led to broad participation. However, a lack of compatible governance causes the unsustainability during the urban renewal process in China. Little research explores the rationale on how far China can learn from its developed counterparts in the governance of urban renewal. Therefore, this paper aims to explore the current problems and future development of urban renewal governance in China by comparing with the UK and Hong Kong. Firstly, it reviews the nature and status quo of governance of urban renewal in China, the UK and Hong Kong respectively; secondly, through comparing characteristics (role of governments, local participation, and decision basis) of urban renewal governance, differences between China and its developed counterparts will be identified; finally, policy implications are drawn for China to deal with future urban renewal and achieve sustainable development.
Micronutrient Status and Human Immunodeficiency Virus (HIV) Infection (1990)

This study surveyed serum concentrations of vitamins, electrolytes, and trace elements in subjects seropositive for HIV-1 by ELISA and confirmatory Western blot. Thirty subjects (26 males, 4 females) were recruited at a hospital clinic. Seventeen were classified as having mild or severe ARC (AIDS-related complex), 7 had AIDS, and 6 were asymptomatic. Eight had experienced weight loss of 10 pounds or more in the past 6 months. Most (93%) were anergic to skin test antigens. Percentages of subjects with below normal plasma concentrations include: zinc-30%, calcium-27%, magnesium-30%, carotenes-31%, total choline-50%, and ascorbate-27%. Eighty-seven percent of the subjects had at least one abnormally low value. Percentages with above normal values include: folate-37% and carnitine-37%. Some subjects with above normal values for plasma vitamins reported self-supplementation, usually with large doses. The results suggest that one or more abnormally low concentrations of the plasma micronutrients studied here are likely to be present in the majority of HIV seropositive patients.
DNA variants at the LPL gene locus associate with angiographically defined severity of atherosclerosis and serum lipoprotein levels in a Welsh population. (1994)

Coronary artery disease (CAD) patients (n = 235), comprising minimal (CAD-, n = 124) and severe (CAD+, n = 111) CAD, were recruited on the basis of their angiographic scores. Male control subjects (n = 123) were selected randomly from the Caerphilly Heart Study cohort. Subjects were genotyped for the Ser447-Ter mutation and HindIII/Pvu II restriction fragment length polymorphisms of the lipoprotein lipase gene and investigated for associations with severity and development of CAD and lipid and lipoprotein levels. The Ser447-Ter mutation showed no significant associations with CAD or dyslipidemia but was related to favorable lipid and lipoprotein profiles. The H2H2 genotype (P < .05) and H2 allele (P = .05) were significantly more frequent in CAD+ versus CAD- and control subjects versus CAD-. H2H2 subjects, among the entire male cohort, had significantly higher levels of apolipoprotein B (P = .0002), total cholesterol (P < .004), and triglycerides (P < .04) than alternative genotypes. P2P2 associated with significantly lower high-density lipoprotein cholesterol levels (P < .01). The H2 allele had most significant associations with raised apolipoprotein B levels compared with other biochemical parameters. Our data suggest that the H2 allele may be a linkage marker for an etiologic mutation for dyslipidemia and the severity and development of atherosclerosis; this is not the Ser447-Ter mutation.
Enhanced Levels of the Aroma and Flavor Compound<i>S-</i>Linalool by Metabolic Engineering of the Terpenoid Pathway in Tomato Fruits (2001)

The aromas of fruits, vegetables, and flowers are mixtures of volatile metabolites, often present in parts per billion levels or less. We show here that tomato (Lycopersicon esculentum Mill.) plants transgenic for a heterologous Clarkia breweri S-linalool synthase (LIS) gene, under the control of the tomato late-ripening-specific E8 promoter, synthesize and accumulate S-linalool and 8-hydroxylinalool in ripening fruits. Apart from the difference in volatiles, no other phenotypic alterations were noted, including the levels of other terpenoids such as gamma- and alpha-tocopherols, lycopene, beta-carotene, and lutein. Our studies indicate that it is possible to enhance the levels of monoterpenes in ripening fruits by metabolic engineering.