gebhart/patrepeval huggingface dataset:
Use of Nonionic Surfactants for Improvement of Terpene Production in Saccharomyces cerevisiae (2014)

To facilitate enzyme and pathway engineering, a selection was developed for improved sesquiterpene titers in Saccharomyces cerevisiae. α-Bisabolene, a candidate advanced biofuel, was found to protect yeast against the disruptive action of nonionic surfactants such as Tween 20 (T20). An experiment employing competition between two strains of yeast, one of which makes twice as much bisabolene as the other, demonstrated that growth in the presence of T20 provided sufficient selective pressure to enrich the high-titer strain to form 97% of the population. Following this, various methods were used to mutagenize the bisabolene synthase (BIS) coding sequence, coupled with selection by subculturing in the presence of T20. Mutagenesis targeting the BIS active site did not yield an improvement in bisabolene titers, although mutants were found which made a mixture of α-bisabolene and β-farnesene, another candidate biofuel. Based on evidence that the 3' end of the BIS mRNA may be unstable in yeast, we randomly recoded the last 20 amino acids of the enzyme and, following selection in T20, found a variant which increased specific production of bisabolene by more than 30%. Since T20 could enrich a mixed population, efficiently removing strains that produced little or no bisabolene, we investigated whether it could also be applied to sustain high product titers in a monoculture for an extended period. Cultures grown in the presence of T20 for 14 days produced bisabolene at titers up to 4-fold higher than cultures grown with an overlay of dodecane, used to sequester the terpene product, and 20-fold higher than cultures grown without dodecane.
Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. (1995)

The reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) is the major target for antiretroviral therapy of the acquired immunodeficiency syndrome (AIDS). While some inhibitors exhibit activity against most retroviral RTs, others are specific for the HIV-1 enzyme. To develop an animal model for the therapy of the HIV-1 infection with RT inhibitors, the RT of the simian immunodeficiency virus (SIV) was replaced by the RT of HIV-1. Macaques infected with this SIV/HIV-1 hybrid virus developed AIDS-like symptoms and pathology. The HIV-1-specific RT inhibitor LY300046.HCl, but not zidovudine [3'-azido-3'-deoxythymidine (AZT)] delayed the appearance of plasma antigenemia in macaques infected with a high dose of the chimeric virus. Infection of macaques with the chimeric virus seems to be a valuable model to study the in vivo efficacy of new RT inhibitors, the emergence and reversal of drug resistance, the therapy of infections with drug-resistant viruses, and the efficacy of combination therapy.
LXV.—Metallic compounds containing bivalent hydrocarbon radicles. Part II (1881)

J. Sakurai, J. Chem. Soc., Trans., 1881, 39, 485 DOI: 10.1039/CT8813900485
Polycarbonate/acrylonitrile–styrene–acrylic elastomer terpolymer blends with enhanced interfacial adhesion and surface gloss (2005)

Abstract A blend of bisphenol A polycarbonate (PC) and an acrylonitrile–styrene–acrylic elastomer (ASA) terpolymer with high surface gloss and excellent interfacial properties was developed for automobile applications. Because PC and the styrene‐ co ‐acrylonitrile (SAN) copolymer that formed the matrix in the PC/ASA blend were not miscible, two different types of compatibilizers were examined to improve the compatibility of the blend. A diblock copolymer composed of tetramethyl polycarbonate and poly(methyl methacrylate) (PMMA) was more effective than PMMA in increasing interfacial adhesion between PC and SAN. The surface gloss of the PC/ASA blend was always lower than that of the pure ASA included in the blend because of PC existing at the surface of the injection‐molding specimen. The PC/ASA blend with optimum surface gloss and enhanced interfacial adhesion was developed through the control of the molecular weight of PC and the compatibilizer. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 96: 2097–2104, 2005
Unbiased reduced density matrices and electronic properties from full configuration interaction quantum Monte Carlo (2014)

Properties that are necessarily formulated within pure (symmetric) expectation values are difficult to calculate for projector quantum Monte Carlo approaches, but are critical in order to compute many of the important observable properties of electronic systems. Here, we investigate an approach for the sampling of unbiased reduced density matrices within the full configuration interaction quantum Monte Carlo dynamic, which requires only small computational overheads. This is achieved via an independent replica population of walkers in the dynamic, sampled alongside the original population. The resulting reduced density matrices are free from systematic error (beyond those present via constraints on the dynamic itself) and can be used to compute a variety of expectation values and properties, with rapid convergence to an exact limit. A quasi-variational energy estimate derived from these density matrices is proposed as an accurate alternative to the projected estimator for multiconfigurational wavefunctions, while its variational property could potentially lend itself to accurate extrapolation approaches in larger systems.
Lipoprotein(a) Is a Potent Chemoattractant for Human Peripheral Monocytes (1997)

We have previously reported that the serine protease plasmin triggers chemotaxis in human peripheral monocytes, but not in polymorphonuclear leukocyte. We now show that the structurally related lipoprotein(a) (Lp[a]) as well as recombinant apolipoprotein(a) (apo[a]) trigger chemotactic responses in human monocytes equipotent to that observed with the standard chemoattractant FMLP. The chemotactic effects of Lp(a) and FMLP were additive. Low density lipoprotein (LDL) did not elicit any significant chemotactic response nor did it interfere with that triggered by Lp(a). As assessed by checkerboard analysis, Lp(a)-mediated monocyte locomotion was a true chemotaxis. Both plasminogen as well as catalytically inactivated plasmin inhibited monocyte migration elicited by Lp(a), suggesting binding of Lp(a) to plasminogen binding sites. Lp(a)-mediated signaling proceeds through a pertussis toxin-sensitive guanosine triphosphate (GTP)-binding protein and activation of protein kinase C as implicated by the effects of 1-O-hexadecyl-2-O-methyl-rac-glycerol and chelerythrine. Lp(a) induced generation of guanosine 3',5'-cyclic monophosphate (cGMP), apparently crucial for the Lp(a)-mediated chemotaxis, because an inhibitor of soluble guanylyl cyclase, LY83583, reduced both the Lp(a)-induced cGMP formation as well as the monocyte migration. The latter effect of LY83583 was antagonized by the stable cGMP analog 8-pCPT-cGMP. The data indicate that Lp(a) triggers chemotaxis in human monocytes by way of a cGMP-dependent mechanism. Our findings may have important implications for the atherogenesis associated with elevated levels of Lp(a).
Superconducting cavity electro-optics: A platform for coherent photon conversion between superconducting and photonic circuits (2018)

Leveraging the quantum information-processing ability of superconducting circuits and long-distance distribution ability of optical photons promises the realization of complex and large-scale quantum networks. In such a scheme, a coherent and efficient quantum transducer between superconducting and photonic circuits is critical. However, this quantum transducer is still challenging because the use of intermediate excitations in current schemes introduces extra noise and limits bandwidth. We realize direct and coherent transduction between superconducting and photonic circuits based on the triple-resonance electro-optic principle, with integrated devices incorporating both superconducting and optical cavities on the same chip. Electromagnetically induced transparency is observed, indicating the coherent interaction between microwave and optical photons. Internal conversion efficiency of 25.9 ± 0.3% has been achieved, with 2.05 ± 0.04% total efficiency. Superconducting cavity electro-optics offers broad transduction bandwidth and high scalability and represents a significant step toward integrated hybrid quantum circuits and distributed quantum computation.
Rotational Isomerization Barriers of Thiophene Oligomers in the Ground and First Excited Electronic States. A 1H NMR and Fluorescence Lifetime Investigation (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRotational Isomerization Barriers of Thiophene Oligomers in the Ground and First Excited Electronic States. A 1H NMR and Fluorescence Lifetime InvestigationJ. C. Horne, G. J. Blanchard, and E. LeGoffCite this: J. Am. Chem. Soc. 1995, 117, 37, 9551–9558Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ja00142a025https://doi.org/10.1021/ja00142a025research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Generating effective confirmation and guidance using two-level confidence measures for dialogue systems (2000)

We present a method to generate effective confirmation and guidance using concept-level confidence measures (CM) derived from speech recognizer output in order to handle speech recognition errors. We define two conceptlevel CM, which are on content-words and on semanticattributes, using 10-best outputs of the speech recognizer and parsing with phrase-level grammars. Content-word CM is useful for selecting plausible interpretations. Less confident interpretations are given to confirmation process, and non-confident ones are rejected. The strategy improved the interpretation accuracy by 11.5%. Moreover, the semantic-attribute CM is used to estimate user’s intention and generates system-initiative guidances even when successful interpretation is not obtained.
Wearable Tetherless Computer-Mediated Reality: WearCam as a wearable face-recognizer, and other applications for the disabled (1996)

`WearCam&apos;, a wearable multimedia system with video processing capability and wireless Internet connection, has recently been proposed(Mann 1994b). In this paper, WearCam is presented as a prosthetic device. In particular, two example applications: the `personal visual assistant&apos;; and the `visual memory prosthetic &apos; are described. The `personal visual assistant &apos; embodies a spatial visual filter(Mann 1994a) that reconfigures the human visual system, providing a coordinate transformation (remapping of spatial coordinates). Such coordinate transformations, it is hoped, might someday be of use to the partially sighted. The `visual memory prosthetic(?)&apos; embodies a temporal visual filter that provides computerinduced flashbacks (possibly together with annotation) . These `flashbacks&apos; currently help the author overcome visual amnesia. It is hoped that, with further research, the apparatus and approach might someday lead to perceptual intelligence that we can wear, and be of great benefit to...
Antibodies to the <i>alpha</i>-subunit of insulin receptor from eggs of immunized hens. (1985)

Abstract Simple methods for the generation, purification, and assay of antibodies to the alpha-subunit of insulin receptor from eggs of immunized hens have been described. Chicken antibodies against the alpha-subunit inhibit insulin binding to the receptor and stimulate glucose oxidation as well as autophosphorylation of the beta-subunit. Thus the properties of chicken antibodies are very similar to those of antibodies found in human autoimmune diseases and different from rabbit antibodies obtained against the same antigen.
Nucleotide Sequences of a Soybean Complementary DNA Encoding a 50-Kilodalton Late Embryogenesis Abundant Protein (1992)

We report the sequence of a cDNA clone, pGmPM2, corresponding to a soybean mature seed-abundant mRNA (GmPM2).The characteristics of pGmPm2 cDNA are given in Table I.It was selected from a pod-dried cotyledon cDNA XZAPII library screened by differential hybridization with single-stranded cDNA probes prepared from immature seeds (35 DAF) and pod-dried seeds poly(A+) RNA (7). Figure 1 shows the nt sequences of the 1741-base pair cDNA insert and the derived aa sequence.Only one long open reading frame was found, and the mol wt of the deduced protein was similar to that predicted by hybrid select translation (7).The deduced protein is very hydrophilic, as are most other Lea proteins (3), and consists of 463 aa residues corresponding to a molecular mass of 50.6 kD.One potential polyadenylation signal, AATAAA, is found in the 3'-noncoding region, 102 nt upstream from the poly(A+) tail.A search for polypeptide homologies in data banks revealed a strong local similarity with several Lea proteins, including embryonic protein DC8 in carrot (4), Lea proteins D7 and D29 in cotton (1), ABA-induced protein PHVA1 in barley (6), and Lea protein 76 in rape (5).These genes have been shown to be expressed during late seed
Degradations in Gbit/s DFB laser transmission systems due to phase-to-intensity noise conversion by multiple reflection points (1988)

Severe system degradations and bit error rate floors are observed in Gbit/s fibre transmission systems due to the interferometric conversion of laser phase noise to intensity noise by multiple reflections from connectors and splices. Studies of penalties as a function of both the magnitude and number of reflections indicate that fibre joints with guaranteed minimum return losses of better than 20dB may be required for high-speed direct detection systems as well as future coherent systems, even though optical isolators may be employed in such systems.
Liquid-Phase Hydrogenation of Acetylene in a Monolithic Catalyst Reactor (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid-Phase Hydrogenation of Acetylene in a Monolithic Catalyst ReactorRolf K. Edvinsson, Anna M. Holmgren, and Said IrandoustCite this: Ind. Eng. Chem. Res. 1995, 34, 1, 94–100Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/ie00040a007https://doi.org/10.1021/ie00040a007research-articleACS PublicationsRequest reuse permissionsArticle Views407Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expected frequencies of DNA patterns using whittle's formula (1991)

Given a realisation of a Markov chain, one can count the numbers of state transitions of each type. One can ask how many realisations are there with these transition counts and the same initial state. Whittle (1955) has answered this question, by finding an explicit though complicated formula, and has also shown that each realisation is equally likely. In the analysis of DNA sequences which comprise letters from the set {A, C, G, T}, it is often useful to count the frequency of a pattern, say ACGCT, in a long sequence and compare this with the expected frequency for all sequences having the same start letter and the same transition counts (or ‘dinucleotide counts' as they are called in the molecular biology literature). To date, no exact method exists; this paper rectifies that deficiency.
An efficient scheduling scheme for high speed IEEE 802.11 WLANs (2003)

The emergence of high speed WLANs, such as the IEEE 802.11a and IEEE 802.11g, has provided an alternative solution for mobile users to access a network in addition to the popular IEEE 802.11b solution. Although the channel data rate of those emerging high speed WLANs is five times higher than that of 802.11b, some recent studies have shown that the throughput of IEEE 802.11 drops as the channel data rate increases, and the throughput upper limit do exist when the channel data rate goes to infinite high. These findings indicate that the performance of a WLAN will not be efficiently improved by merely increasing the channel data rate. In this paper, we propose a new protocol scheme that makes use of an out-of-band signaling (OBS) technique. The proposed scheme provides better bandwidth usage compared to the in-band signaling technique in the existing scheme and is compatible with the existing IEEE 802.11 standard.
Contact diode laser microvascular anastomosis (1993)

Contact diode laser microvascular anastomosis appears to be a valuable technique for anastomosing small arteries and veins. Significantly less foreign body reaction and markedly decreased operative time has been shown to be a major advantage of using contact diode laser technology. The authors have found that contact diode laser anastomosis can be performed in vessels as small as 1 mm in size using a 200-microns flat tip synthetic sapphire probe. Light microscopy has shown a significant decrease in foreign body reaction at the level of the anastomosis using laser techniques as compared to standard vessel anastomosis with 10-0 nylon sutures. The role of fibronectin and changes in collagen associated with laser anastomosis were also explored. Light microscopic electron-microscopic results as well as biotin-avidin immunoperoxidase fibronectin studies will be discussed.
Characterization of signals by the ridges of their wavelet transforms (1997)

The characterization and the separation of amplitude and frequency modulated signals is a classical problem of signal analysis and signal processing. We present a couple of new algorithmic procedures for the detection of ridges in the modulus of the (continuous) wavelet transform of one-dimensional (1-D) signals. These detection procedures are shown to be robust to additive white noise. We also derive and test a new reconstruction procedure. The latter uses only information from the restriction of the wavelet transform to a sample of points from the ridge. This provides a very efficient way to code the information contained in the signal.
An Efficient Traversal Algorithm for Large Hypergraphs and its Applications for Graph Analysis (2017)

하이퍼그래프는 노드와 여러 노드를 연결할 수 있는 하이퍼에지로 구성된다. 하이퍼그래프 분석을 위해 그래프 기본 연산 중 그래프 탐색을 사용할 수 있다. 일반 그래프에 사용되는 DFS, BFS 탐색방법을 하이퍼그래프에 그대로 적용하였을 시 여러 노드를 연결하는 하이퍼에지의 특성을 고려하지 않는 문제가 있다. 본 논문에서는 하이퍼그래프를 위한 DBMS인 hypergraphDB에 저장 된 그래프 탐색 시 에지 단위로 탐색 여부를 판단하는 방법을 제안하고, 제안 탐색 방법을 응용한 하이퍼그래프 분석 실험을 수행하였다. 실험을 통해 일반 그래프의 탐색 기법을 적용한 경우 보다 빠른 속도와 보다 적은 DB 접근 횟수로 그래프 분석 작업을 수행함을 보인다.
The Role of Pharmacokinetics and Pharmacodynamics in the Development of Biotech Drugs (2006)

This chapter contains sections titled: Introduction Biotech Drugs and the Pharmaceutical Industry Pharmacokinetics and Pharmacodynamics in Drug Development PK and PK/PD Pitfalls for Biotech Drugs Regulatory Guidance Future References
Interaction between Protein, Phytate, and Microbial Phytase. In Vitro Studies (2006)

The interaction between protein and phytate was investigated in vitro using proteins extracted from five common feedstuffs and from casein. The appearance of naturally present soluble protein-phytate complexes in the feedstuffs, the formation of complexes at different pHs, and the degradation of these complexes by pepsin and/or phytase were studied. Complexes of soluble proteins and phytate in the extracts appeared in small amounts only, with the possible exception of rice pollards. Most proteins dissolved almost completely at pH 2, but not after addition of phytate. Phytase prevented precipitation of protein with phytate. Pepsin could release protein from a precipitate, but the rate of release was increased by phytase. Protein was released faster from a protein-phytate complex when phytase was added, but phytase did not hydrolyze protein. Protein was released from the complex and degraded when both pepsin and phytase were added. It appears that protein-phytate complexes are mainly formed at low pH, as occurs in the stomach of animals. Phytase prevented the formation of the complexes and aided in dissolving them at a faster rate. This might positively affect protein digestibility in animals.
Packaging and wired interconnections for insertion of miniaturized chips in smart fabrics (2009)

Electronic devices are currently used in a complete system including mobile phone, television etc… Now, more and more applications need functionality as close as possible to the final system for in situ measurement and control (smart textile, automotive or medical applications) or for security. The components concerned are sensors, light emitting diodes or RFID for example. Concerning microsystem, being integrated in a material means several key properties, including a packaging form adapted to the material manufacturing process, autonomy in terms of energy means for being powered, neutrality versus the initial material properties and resilience, as materials usually get post-processed once manufactured. A particularly attractive support for such integration is the textile way, since textile or textile-like materials are often part of composite materials and are extremely common in the design of complex objects. The process aims at a direct connection from a chip assembly to external wires without using the traditional bonding / packaging stage. Through a very limited set of wafer scale operations, one or several chip dies can be assembled and connected to conductive wires directly from the chip surface. The result of a fully processed Diabolo assembly is a spool of chips connected to a flexible wire that can be used for incorporation into materials through taping, weaving, knitting, extrusion or more generally inclusion in a liquid phase before curing. The process is still in its early stage of development but our current studies make us confident that assembly throughput as high as 10k UPH (Unit per Hour) can be reached with a relatively simple equipment.
Shear Reinforcement For Deflection Ductility of Flat Plates (1990)

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