gebhart/patrepeval huggingface dataset:
Prevention of acetaminophen-induced liver damage by Berberis aristata leaves (1992)

Conference Article| November 01 1992 Prevention of acetaminophen-induced liver damage by Berberis aristata leaves ANWAR H. GILANI; ANWAR H. GILANI 1Department of Pharmacology, Faculty of Health Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan Search for other works by this author on: This Site PubMed Google Scholar KHALID H. JANBAZ KHALID H. JANBAZ 1Department of Pharmacology, Faculty of Health Sciences, The Aga Khan University Medical College, Karachi-74800, Pakistan Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1992 Biochemical Society1992 Biochem Soc Trans (1992) 20 (4): 347S. https://doi.org/10.1042/bst020347s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation ANWAR H. GILANI, KHALID H. JANBAZ; Prevention of acetaminophen-induced liver damage by Berberis aristata leaves. Biochem Soc Trans 1 November 1992; 20 (4): 347S. doi: https://doi.org/10.1042/bst020347s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1992 Biochemical Society1992 Article PDF first page preview Close Modal You do not currently have access to this content.
Transmission‐blocking antibodies against multiple, non‐variant target epitopes of the <i>Plasmodium falciparum</i> gamete surface antigen Pfs230 are all complement‐fixing (1994)

We have studied the properties of 16 newly derived monoclonal antibodies (MoAbs) against Pfs230, a gamete surface protein of Plasmodium falciparum and a target of transmission-blocking antibodies. All 16 MoAbs recognized Pfs230 by immunoprecipitation from non-ionic detergent extracts of the protein radio-labelled with 125Iodine. The MoAbs also recognized this protein on Western blots under non-reducing conditions but none of them recognized the protein under reducing conditions. Using an immunoradiometric assay the MoAbs appear to define nine different epitope regions. The MoAbs were tested for their ability to lyse extra-cellular female gametes of P. falciparum isolate 3D7. Eight of the MoAbs, all of isotype IgG2a, mediated complement-dependent lysis of the gametes; seven of the MoAbs, all isotype IgG1, failed to lyse the gametes in the presence of active complement. The eight complement-fixing MoAbs mediated almost total suppression of infectivity of gametocytes of P. falciparum 3D7 to mosquitoes; where tested this suppression was mainly complement-dependent. The seven non-complement-fixing MoAbs had no significant effect on the infectivity of gametocytes of P. falciparum 3D7 to mosquitoes. When tested by immunofluorescence the target epitopes of all the MoAbs were conserved in each of the five different isolates of P. falciparum which were tested.
Pterostilbene Simultaneously Induced G0/G1-Phase Arrest and MAPK-Mediated Mitochondrial-Derived Apoptosis in Human Acute Myeloid Leukemia Cell Lines (2014)

Taken together, our results suggest that PTER induced HL-60 cell death via MAPKs-mediated mitochondria apoptosis pathway and loss of LMP might be another cause for cell apoptosis induced by PTER.
A 4&pi;-Underwater Irradiance Meter (1966)

海洋における基礎生産力の測定などの研究において, 水中光の測定は重要な役割をはたす. 然し今まではその測定装置や測定方法がまちまちで, 測定結果の比較検討が困難な現状である.この問題を解決する目的で, その第1段階として, 下向と上向の放射照度を同時に測定できる4π水中放射照度計の研究・試作を行なった.本装置は大別して水中測定部, 船上測定部, 深度計, ケーブルおよび天空放射照度計より成り, 水深100mまで任意の深さで測定できる. 受光部にはCdS光導電セルを使用した.最初に, 太陽高度や水深などの変化に対して, 水中放射照度にいかなる影響があるかを知るために測定を行なった二, 三の結果について報告する.
Naturally Acquired MAGE-A10- and SSX-2-Specific CD8+ T Cell Responses in Patients with Hepatocellular Carcinoma (2005)

Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation of highly targeted vaccines. HCC express a variety of tumor-specific Ags, raising the question whether CTL specific for such Ags exist in HCC patients. Indeed, a recent study revealed CTLs specific for two cancer-testis (CT) Ags (MAGE-A1 and MAGE-A3) in tumor infiltrating lymphocytes of HCC patients. Here we assessed the presence of T cells specific for additional CT Ags: MAGE-A10, SSX-2, NY-ESO-1, and LAGE-1, which are naturally immunogenic as demonstrated in HLA-A2(+) melanoma patients. In two of six HLA-A2(+) HCC patients, we found that MAGE-A10- and/or SSX-2-specific CD8(+) T cells naturally responded to the disease, because they were enriched in tumor lesions but not in nontumoral liver. Isolated T cells specifically and strongly killed tumor cells in vitro, providing evidence that these CTL were selected in vivo for high avidity Ag recognition. Therefore, besides melanoma, HCC is the second solid human tumor with clear evidence for in vivo tumor recognition by T cells, providing the rational for specific immunotherapy, based on immunization with CT Ags such as MAGE-A10 and SSX-2.
Biofilms: A microbial home (2011)

Microbial biofilms are mainly implicated in etiopathogenesis of caries and periodontal disease. Owing to its properties, these pose great challenges. Continuous and regular disruption of these biofilms is imperative for prevention and management of oral diseases. This essay provides a detailed insight into properties, mechanisms of etiopathogenesis, detection and removal of these microbial biofilms.
A thermo-optic photonic switch (2010)

This paper reports a compact silicon-based thermo-optic switch using photonic wire waveguides. The switch is constructed in Mach-Zehnder interferometer (MZI) configuration on a silicon substrate. The switching operation is achieved through thermo-optic effect. In the experiments, an extinction ratio about 25 dB at the wavelength of 1590 nm is obtained. The switching power is around 180 mW.
Isolation and Characterization of Porcine Cationic Eosinophil Granule Proteins (1996)

The allergic pig can be used as a large-animal model for studies of allergic reactions in the airways and the role of eosinophils in such reactions. To measure the activation of eosinophils, the release of eosinophil-derived cationic proteins can be used. The purpose of this study was to isolate and characterize cationic proteins derived from porcine eosinophils. Pigs were infested with live Ascaris suum eggs to induce eosinophilia (greater than or = 40% of leukocytes). Blood was collected and leukocytes were prepared by dextran sedimentation. Granules were obtained from the homogenized leukocytes by ultracentrifugation and cationic proteins were extracted and separated by gel filtration, cation exchange and zinc affinity chromatography. Using these methods, three cationic proteins were isolated from pig granulocytes, two of which were shown to originate from the eosinophil. The proteins were characterized according to molecular weight, amino acid composition, N-terminal sequence, isoelectric point, peroxidase and ribonuclease activity and antigenicity. One eosinophil protein was identified as eosinophil peroxidase and the other showed great similarities with human eosinophil cationic protein. The third protein was not specific for eosinophils, and had no obvious equivalent in human granulocytes. The eosinophil-derived proteins may be useful in the studies of eosinophil activation, e.g. in late-phase asthmatic reactions, where the pig represents a new candidate model for large-animal allergy research.
<i>HERSCHEL</i>MEASUREMENTS OF MOLECULAR OXYGEN IN ORION (2011)

We report observations of three rotational transitions of molecular oxygen (O2) in emission from the H2 Peak 1 position of vibrationally excited molecular hydrogen in Orion. We observed the 487 GHz, 774 GHz, and 1121 GHz lines using the Heterodyne Instrument for the Far Infrared on the Herschel Space Observatory, having velocities of 11 km s–1 to 12 km s–1 and widths of 3 km s–1. The beam-averaged column density is N(O2) = 6.5 × 1016 cm–2, and assuming that the source has an equal beam-filling factor for all transitions (beam widths 44, 28, and 19''), the relative line intensities imply a kinetic temperature between 65 K and 120 K. The fractional abundance of O2 relative to H2 is (0.3-7.3) × 10–6. The unusual velocity suggests an association with a ~5'' diameter source, denoted Peak A, the Western Clump, or MF4. The mass of this source is ~10 Msun and the dust temperature is ≥150 K. Our preferred explanation of the enhanced O2 abundance is that dust grains in this region are sufficiently warm (T ≥ 100 K) to desorb water ice and thus keep a significant fraction of elemental oxygen in the gas phase, with a significant fraction as O2. For this small source, the line ratios require a temperature ≥180 K. The inferred O2 column density sime5 × 1018 cm–2 can be produced in Peak A, having N(H2) sime 4 × 1024 cm–2. An alternative mechanism is a low-velocity (10-15 km s–1) C-shock, which can produce N(O2) up to 1017 cm–2.
Concurrent-simulation-based remote IP evaluation over the internet for system-on-a-chip design (2001)

We propose an Internet-based concurrent-simulation scheme to ease intellectual property (IP) evaluation process between IP vendors and users. Complex system-on-a-chip (SOC) design requires more and more IP modules from third party vendors. What can be disclosed by the vendor without impairing its trade secret and what needs to be examined by the user to gain satisfactory level of confidence are contradictory of each other. Via PLI interface functions and Internet protocol, our proposed software enables HDL simulators (Verilog) residing in both the vendor and user's sites to concurrently simulate the IP and SOC together. Only stimulus and response defined in the IP's I/O are exchanged between the sites. Therefore, the vendor need not to create a functional model (or encrypted code) for the IP while the user is assured what he/she simulates is what he/she will purchase. Beside simulation speed degradation due to communication overhead, the. SOC design/debug process is exactly same as if the IP is in the user's hand. Our contribution will help all IP providers expose their IPs to all potential users without human intervention and IP right infringement concern.
Molecular Characterisation of Bacterial Community Structure along the Intestinal Tract of Zebrafish (<i>Danio rerio</i>): A Pilot Study (2012)

The bacterial composition along the intestinal tract of Danio rerio was investigated by cultivation-independent analysis of the 16S rRNA gene. Clone libraries were constructed for three compartments of the intestinal tract of individual fish. 566 individual clones were differentiated by amplified 16S rRNA gene restriction analysis (ARDRA), and clone representatives from each operational taxonomic unit (OTU) were sequenced. As reported in other studies, we found that Proteobacteria was the most prominent phylum among clone libraries from different fish. Data generated from this pilot study indicated some compositional differences in bacterial communities. Two dominant classes, Gammaproteobacteria and Bacilli, displayed different levels of abundance in different compartments; Gammaproteobacteria increased along the intestinal tract, while Bacilli decreased its abundance along the proximal-distal axis. Less obvious spatial patterns were observed for other classes. In general, bacterial diversity in the intestinal bulb was greater than that in the posterior intestine. Interindividual differences in bacterial diversity and composition were also noted in this study.
Biological Investigations of New Wine Bottles (1960)

Bottles off a heat-annealing conveyor, either open or closed with a plastic stopper, in cases closed with an adhesive ribbon, may be used unrinsed for the bottling of dry wine. Microorganism is new bottles will be further diminished by disinfecting the end of the heat-annealing equipment. Then even sweet table wines can be filled, as proposed and practiced in Germany.
Optical resolution by direct crystallization of enantiomer mixtures (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical resolution by direct crystallization of enantiomer mixturesAndre Collet, Marie Josephe Brienne, and Jean JacquesCite this: Chem. Rev. 1980, 80, 3, 215–230Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/cr60325a001https://doi.org/10.1021/cr60325a001research-articleACS PublicationsRequest reuse permissionsArticle Views2385Altmetric-Citations268LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gossip-based ad hoc routing (2006)

Many ad hoc routing protocols are based on some variant of flooding. Despite various optimizations of flooding, many routing messages are propagated unnecessarily. We propose a gossiping-based approach, where each node forwards a message with some probability, to reduce the overhead of the routing protocols. Gossiping exhibits bimodal behavior in sufficiently large networks: in some executions, the gossip dies out quickly and hardly any node gets the message; in the remaining executions, a substantial fraction of the nodes gets the message. The fraction of executions in which most nodes get the message depends on the gossiping probability and the topology of the network. In the networks we have considered, using gossiping probability between 0.6 and 0.8 suffices to ensure that almost every node gets the message in almost every execution. For large networks, this simple gossiping protocol uses up to 35% fewer messages than flooding, with improved performance. Gossiping can also be combined with various optimizations of flooding to yield further benefits. Simulations show that adding gossiping to AODV results in significant performance improvement, even in networks as small as 150 nodes. Our results suggest that the improvement should be even more significant in larger networks
Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy (2005)

Macrophages are key components of the inflammatory response to tissue injury, but their activities can exacerbate neuropathology. High-resolution magnetic resonance spectroscopy was used to identify metabolite levels in perchloric acid extracts of cultured cells of the RAW 264.7 murine macrophage line under resting and lipopolysaccharide-activated conditions. Over 25 metabolites were identified including gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter not previously reported to be present in macrophages. The presence of GABA was also demonstrated in extracts of human peripheral blood monocyte-derived macrophages. This finding suggests that there may be communication between damaged central nervous system (CNS) tissue and recruited macrophages and resident microglia, which could help orchestrate the immune response. On activation, lactate, glutamine, glutamate, and taurine levels were elevated significantly, and GABA and alanine were reduced significantly. Strong resonances from glutathione, evident in the macrophage two-dimensional 1H spectrum, suggest that this may have potential as a noninvasive marker of macrophages recruited to the CNS, as it is only present at low levels in normal brain. Alternatively, a specific combination of spectroscopic changes, such as lactate, alanine, glutathione, and polyamines, may prove to be the most accurate means of detecting macrophage recruitment to the CNS.
TORSION OF THE ACHILLES TENDON: ITS SURGICAL SIGNIFICANCE (1943)

Lengthening the heel cord is the commonest single operative procedure in the repertoire of most orthopedic surgeons, and the reporting of any simplification of the technic seems justified, particularly if it brings to light an interesting embryologic phenomenon which explains the internal arrangement of the fibers of that structure, not generally appreciated. Before I developed my special but simple technic of subcutaneous tenotomy, I had abandoned that procedure because of frequent inability to get the severed tendon elements to slide apart, regardless of the near completeness of the alternate transverse cuts, and had employed an open tenoplastic technic, converting what should be a relatively simple operation into a much more formidable one. The satisfaction that has long accompanied this lengthening procedure, together with the continual urging of my friends that I publish a description of the procedure, has finally prompted me to finish a task started many years ago. when
Farnesyl-diphosphate synthase is localized in peroxisomes. (1994)

In this study, we have investigated the subcellular localization of farnesyl-diphosphate synthase (FPP synthase). FPP synthase produces FPP, which is utilized in the synthesis of squalene, cholesterol, farnesylated and geranylgeranylated proteins, dolichols, coenzyme Q, and the isoprenoid moiety of heme a. This enzyme is found in the 100,000 x g supernatant fraction of cells or tissues and has been considered to be a cytoplasmic protein. In this study, analysis of FPP synthase activity and protein in fractionated rat liver together with immunofluorescent and immunoelectron microscopy studies demonstrated unequivocally that FPP synthase is largely localized in peroxisomes. These data, in combination with the previous observation that mevalonate kinase is predominantly localized in peroxisomes, suggest that peroxisomes are the major site of synthesis of FPP from mevalonate. We also demonstrate that in liver tissue obtained from patients with peroxisomal deficiency diseases (Zellweger syndrome and neonatal adrenoleukodystrophy), the activities of five enzymes involved in isoprenoid synthesis, namely mevalonate kinase, phosphomevalonate kinase, mevalonate-diphosphate decarboxylase, isopentenyl-diphosphate isomerase, and FPP synthase, are significantly reduced, consistent with a peroxisomal localization of these enzymes.
A geodesic optical waveguide lens fabricated by anisotropic etching (1979)

A geodesic optical waveguide lens which has been fabricated by anisotropic etching on a silicon substrate is reported. Reflow of phosphosilicate glass provides considerable rounding at sharp edges to reduce scattering. Successful operation of the waveguide lens is illustrated by observation of guided beam trajectories traversing different portions of the lens and converginng to a common point and by measurements of the focal-plane diffraction pattern. A beam width which is 1.7 times the diffraction-limited value for a f/15 lens is measured.
The Adsorption of Water Vapor on Carbon Black (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Adsorption of Water Vapor on Carbon BlackP. H. Emmett and R. B. AndersonCite this: J. Am. Chem. Soc. 1945, 67, 9, 1492–1494Publication Date (Print):September 1, 1945Publication History Published online1 May 2002Published inissue 1 September 1945https://pubs.acs.org/doi/10.1021/ja01225a025https://doi.org/10.1021/ja01225a025research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Energy efficient transmission scheduling for delay constrained wireless networks (2006)

10.1109/TWC.2006.1603968
Microgravity and Signaling Molecules in Rat Osteoblasts: Downstream of Receptor Tyrosine Kinase, G-Protein-Coupled Receptor, and Small GTP-Binding Proteins (2005)

Rat osteoblasts were cultured for 4 and 5 days aboard Space Shuttle and solubilized on board. The mRNA levels of the post-receptor signaling molecules were analyzed by quantitative RT-PCR. The G-protein alpha subunit G(alpha)q mRNA levels were elevated 3-fold by microgravity. G(alpha)q stimulates PLC(beta), and then PKC. PKC(delta) and PKC(theta) mRNA levels were increased 2- to 5-fold by microgravity The mRNA levels of SOS and Ras GRF were increased 4 to 5-fold by microgravity, while Ras GAP was not altered. Spaceflight-induced bone loss might be attributed to microgravity modulation of the signaling pathway in osteoblasts.
Active Time-Domain Reflectometry for Tamper Indication in Unattended Monitoring Systems for Safeguards (2015)

iii Acknowledgments v Acronyms and Abbreviations vii 1.0 Introduction 1 2.0 Swept-Frequency Time-Domain Reflectometry 3 2.1 Swept Frequency TDR: Testing Arrangement 4 2.2 Cable Tamper: Preliminary Findings 5 2.3 Cable Splice: Preliminary Findings 6 3.0 Spread-Spectrum TDR with LiveWire 11 3.1 LiveWire: Testing Arrangement 12 3.2 LiveWire: Preliminary Findings 14 4.0 Conclusions and Next Steps 15 5.0 References 16 Appendix A Preliminary RG71 Cable Testing A.1