gebhart/patrepeval huggingface dataset:
Towards a Coherent Statistical Framework for Dense Deformable Template Estimation (2007)

Summary The problem of estimating probabilistic deformable template models in the field of computer vision or of probabilistic atlases in the field of computational anatomy has not yet received a coherent statistical formulation and remains a challenge. We provide a careful definition and analysis of a well-defined statistical model based on dense deformable templates for grey level images of deformable objects. We propose a rigorous Bayesian framework for which we prove asymptotic consistency of the maximum a posteriori estimate and which leads to an effective iterative estimation algorithm of the geometric and photometric parameters in the small sample setting. The model is extended to mixtures of finite numbers of such components leading to a fine description of the photometric and geometric variations of an object class. We illustrate some of the ideas with images of handwritten digits and apply the estimated models to classification through maximum likelihood.
Novel Insight Into the Natural History of Short QT Syndrome (2013)

SQTS is highly lethal; CA is often the first manifestation of the disease with a peak incidence in the first year of life. Survivors of CA have a high CA recurrence rate; therefore, implantation of a defibrillator is strongly recommended in this group of patients.
Power control in multi-media CDMA networks (2002)

The performance of a voice/data integrated personal communication system (PCS) employing code division multiple access (CDMA) scheme is analyzed and compared under different reverse link power control strategies based on the equal signal strength (ESS) rule and the equal error probability (EEP) rule. Multimedia multi-rate CDMA system models with convolutional coding and perfect interleaving are presented for a nonfading channel and a fading channel with diversity reception (e.g. RAKE). Upper bounds on the probability of packet error are obtained to evaluate the limits on the system performance. Graceful performance degradation is observed for systems using the ESS rule for traffic with retransmissions while using the EEP rule for traffic without retransmissions.
HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy (2017)

Chemotherapy-induced peripheral neuropathy is one of the most common dose-limiting side effects of cancer treatment. Currently, there is no Food and Drug Administration-approved treatment available. Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase whose function includes regulation of α-tubulin-dependent intracellular mitochondrial transport. Here, we examined the effect of HDAC6 inhibition on established cisplatin-induced peripheral neuropathy. We used a novel HDAC6 inhibitor ACY-1083, which shows 260-fold selectivity towards HDAC6 vs other HDACs. Our results show that HDAC6 inhibition prevented cisplatin-induced mechanical allodynia, and also completely reversed already existing cisplatin-induced mechanical allodynia, spontaneous pain, and numbness. These findings were confirmed using the established HDAC6 inhibitor ACY-1215 (Ricolinostat), which is currently in clinical trials for cancer treatment. Mechanistically, treatment with the HDAC6 inhibitor increased α-tubulin acetylation in the peripheral nerve. In addition, HDAC6 inhibition restored the cisplatin-induced reduction in mitochondrial bioenergetics and mitochondrial content in the tibial nerve, indicating increased mitochondrial transport. At a later time point, dorsal root ganglion mitochondrial bioenergetics also improved. HDAC6 inhibition restored the loss of intraepidermal nerve fiber density in cisplatin-treated mice. Our results demonstrate that pharmacological inhibition of HDAC6 completely reverses all the hallmarks of established cisplatin-induced peripheral neuropathy by normalization of mitochondrial function in dorsal root ganglia and nerve, and restoration of intraepidermal innervation. These results are especially promising because one of the HDAC6 inhibitors tested here is currently in clinical trials as an add-on cancer therapy, highlighting the potential for a fast clinical translation of our findings.
Register allocation for design of data format converters (1991)

The authors use life time analysis and propose systematic register allocation techniques to reuse the registers; register reuse leads to data format converter architectures with fewer registers. A simple forward-circulate allocation scheme is proposed to motivate the use of register allocation, and a more efficient forward-backward register allocation scheme is proposed. Examples of data converters presented include matrix transposer, serial-to-parallel, and parallel-to-serial converters. General m-to-n bit-parallel and bit-serial converters are also studied. It is shown that register allocation techniques can lead to up to 50% savings in hardware area, as compared with converter architectures designed in a straightforward manner.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interfacing optical fibers and high refractive index contrast waveguide circuits using diffractive grating couplers (2009)

The interfacing of an optical fiber and a photonic integrated circuit becomes more complex on a high refractive index contrast waveguide platform due to the large mismatch in mode size between the optical fiber mode and the waveguide modes in the integrated circuit. In this paper we review our work in the field of diffractive grating structures, in order to realize a high efficiency, polarization independent, large bandwidth optical interface with high index contrast waveguides fabricated on the silicon-on-insulator platform.
Compression of the ECG by Prediction or Interpolation and Entropy Encoding (1979)

Compression of digital electrocardiogram (ECG) signals is desirable for two reasons: economic use of storage space for data bases and reduction of the data transmission rate for compatibility with telephone lines. In a sample of 220 Frank4ead ECG's the removal of signal redundancy by second-order prediction or interpolation with subsequent entropy encoding of the respective residual errors was investigated. At the sampling rate of 200 Hz, interpolation provided a 6 dB smaller residual error variance than prediction. A near-optimal value for the interpolation coefficients is 0.5, permitting simple implementation of the algorithm and requiring a word length for arithmetic processing of only 2 bits in extent of the signal precision. For linear prediction, the effects of occasional transmission errors decay exponentially, whereas for interpolation they do not, necessitating error control in certain applications. Encoding of the interpolation errors by a Huffman code truncated to ±5 quantization levels of 30 μV, required an average word length of 2.21 bits/sample (upper 96 percentile 3 bits/sample), resulting in data transmission rates of 1327 bits/s (1800 bits/s) for three simultaneous leads sampled at the rate of 200 Hz. Thus, compared with the original signal of 8 bit samples at 500 Hz, the average compression is 9:1. Encoding of the prediction errors required an average wordlength of 2.67 bits/sample with a 96 percentile of 5.5 bits/sample, making this method less suitable for synchronous transmission.
Design of parallel flexure systems via Freedom and Constraint Topologies (FACT) (2007)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.
Book of Longing (2006)

Book of Longing is Leonard Cohen's astonishing new collection of poems, the first since Book of Mercy was published nearly three decades ago. Leonard made his name as a poet before he came to worldwide attention as a singer and songwriter. Book of Longing, his new collection of poetry, was twenty years in the making and written in Montreal, Mumbai and during his retirement in Mt Baldy. Enhanced by Cohen's own playful and provocative illustrations, these poems show the full range of one of the most influential and enigmatic writers of his generation. Awe-inspiring...Cohen emerges as the wry, sensual mystic his champions have always known he was. (Sunday Telegraph). Exceptional. Clear yet steamy, cosmic yet private, both playful and profound...as soulful a credo as he has ever put on paper. (New York Times). Playful, colourful, erotic...brilliant and sharp as flint. (Big Issue). Dazzling. (Sunday Herald). The best bring an ironic, world-weary sensibility to bear on themes of ageing, sex, sensuality and spirituality. (Financial Times). A fine book of poems. (Time Out). Cohen maps this wasteland of the heart with humour, and sometimes anger. (Independent). Cohen's career began in 1956 with the publication of Let Us Compare Mythologies, and he has since published nine books of poems, and has made numerous internationally successful recordings. In a career spanning fifty years, Leonard has become one of the western world's most popular and innovative creative artists.
Specmurt Analysis Of Multi-Pitch Music Signals With Adaptive Estimation Of Common Harmonic Structure . (2005)

[TODO] Add abstract here.
Detection of Proteins Sumoylated In Vivo and In Vitro (2009)

Small ubiquitin-related modifier (SUMO) is an ubiquitin-like protein that is covalently attached to a variety of target proteins. Unlike ubiquitination, sumoylation does not target proteins for proteolytic breakdown, but is instead involved in regulating multiple protein functional properties including protein-protein interactions and subcellular targeting, to name a few. Protein sumoylation has been particularly well characterized as a regulator of many nuclear processes as well as nuclear structure, making the characterization of this modification vital for understanding nuclear structure and function. Consequently, there has been intense interest in identifying new proteins that are targets of this modification and determining what role it plays in regulating their functions. This chapter presents methodologies for determining whether a particular protein is a substrate of sumoylation, and for identifying the lysine residue(s) where the modification occurs.
[Preparation and in vitro activity of monoclonal antibody-pharmorubicin immunoconjugates]. (1996)

Bifunctional agent adipic dihydrate was used to form hydrazon bond between polyglutamic acid (PGA) and pharmorubicin (PAR). Under controlled condition, a relatively high rate of conjugation was obtained with no self-condensation. The value of PGA/PAR was in positive portion with the molecular weight (MW) of PGA: per 8-11 glutamic acid monomer linking one pharmorubicin. When PGA of MW 14,300 was used as carrier, the ratio of PGA/PAR was 1:11. After conjugating with anti-hepatoma monoclonal antiboty (McAb), an immunoconjugate of McAb:PGA:PAR being 1:2:22 was obtained. The immunoconjugate retained the binding activity to targeted cell compared with the purified and the oxidized antibody. Pharmacological studies in vitro showed lower cytotoxicity of the immunoconjugate than the free drug, but selective cytotoxicity directed by antibody was observed. Consequently, the immunoconjugate McAb-PGA-PAR with high ratio of drug/McAb as well as moderate targeting cytotoxity in vitro was successfully prepared. That makes it possible for the preparation of cell-targeted drug which is expected to be benificial to tumor treatment.
The light shift effect in the coherent population trapping cesium maser (2000)

The light shift, as observed in the coherent population trapping (CPT) maser, was investigated theoretically and experimentally. It was found that the light shift originates from the various sidebands that are present in the spectrum of the frequency-modulated laser used to observe the CPT phenomenon.
156. 2 : 4-Diarylpyrroles. Part I. Synthesis of 2 : 4-diarylpyrroles and 2 : 2′ : 4 : 4′-tetra-arylazadipyrromethines (1943)

M. A. T. Rogers, J. Chem. Soc., 1943, 590 DOI: 10.1039/JR9430000590
Differential expression of mRNA in human monocytes following interaction with human colon cancer cells. (2011)

In THP-1 cells, monocyte chemotactic protein (MCP)-1 mRNA expression increased in a time-dependent manner from day 3 after co-culture with DLD-1 cells; furthermore, expression of vascular endothelial growth factor (VEGF)-A, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-8 mRNA was increased from day 5. This increase in mRNA expression in the THP-1 cells was attributable to the presence of the DLD-1 cells. Therefore, MCP-1, VEGF-A, TNF-α, IL-1β, and IL-8 are suggested to be associated with differentiation of human monocytes into tumor-associated macrophages at human colon cancer sites.
Development of fiber-optic depolarizer and its application to measurement systems for polarization-insensitive operation of silica-waveguide matrix switches (1994)

This paper describes an automatic system that measures the bias and switching currents of all the switch elements in the polarization-insensitive operation of silica-waveguide 8/spl times/8 matrix switches. A new type of depolarizer that can be used for coherent laser sources was compactly packaged with an excess loss of 6 dB. The packaged depolarizer was coupled to an automatic measurement system that was achieved mainly by using two 64-channel power supplies that drive all the heaters of a matrix switch via a computer. By using a DFB laser source at 1305 nm, whose output was unpolarized with the depolarizer, all the switch elements could be adjusted so that they were polarization insensitive within 0.3 dB to any polarization state. About 2 hours were required to complete the measurement for one matrix switch.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Reaction of d-α-Phenethyl Chloride with Silver Nitrite (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of d-α-Phenethyl Chloride with Silver NitriteRichard H. Eastman and Sidney D. RossCite this: J. Am. Chem. Soc. 1946, 68, 11, 2398–2399Publication Date (Print):November 1, 1946Publication History Published online1 May 2002Published inissue 1 November 1946https://pubs.acs.org/doi/10.1021/ja01215a502https://doi.org/10.1021/ja01215a502research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord (1997)

The discovery of the inducible form of cyclo-oxygenase, known as cyclo-oxygenase-2 (COX-2), has provided insight into the mechanisms involved in the inflammatory response. Peripheral inflammation induced by intraplantar injection of carrageenan is associated with a marked increase in COX-2 mRNA and prostaglandins in the surrounding tissue and the accompanying oedema is sensitive to COX-2-selective drugs. In this study, we investigated whether COX-2 in spinal cord was similarly induced by carrageenan and whether the associated development of altered pain sensitivity, hyperalgesia was affected by the COX-2 selective inhibitor DuP 697. Intraplantar injection of carrageenan caused a marked hyperalgesia at 4 h which was significantly attenuated by treatment with DuP 697 (10 mg kg-1). At the same time levels of COX-2 mRNA in lumbar spinal cord were significantly increased two-fold by carrageenan treatment. However, DuP 697 potentiated COX-2 mRNA induction, which indicates the existence of a potential regulatory mechanism to overcome COX-2 inhibition.
IGF binding protein-3 protease regulation: how sweet it is! (1995)

Journal Article IGF binding protein-3 protease regulation: how sweet it is! Get access L C Giudice L C Giudice Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 80, Issue 8, 1 August 1995, Pages 2279–2281, https://doi.org/10.1210/jcem.80.8.7543109 Published: 01 August 1995
Early down-regulation of Bcl-xL expression during megakaryocytic differentiation of thrombopoietin-induced CD34+ bone marrow cells in essential thrombocythemia. (2004)

These results demonstrate that Bcl-xL is down-regulated early during in vitro differentiation of megakaryocytes from ET patients; this might reflect an early entry of megakaryocytes into a degenerating mature stage.
INFUSIONS OF BLOOD AND OTHER FLUIDS VIA THE BONE MARROW (1941)

Substances injected into the marrow cavity are rapidly taken up,<sup>1</sup>apparently unchanged, into the general circulation.<sup>2</sup>The problem of administering fluids to infants is a difficult one, especially when rapid absorption is desired. The two main routes available, aside from the peripheral veins themselves, are the superior longitudinal sinus, reached through the anterior fontanel, and the peritoneal cavity. The infusion of substances through the anterior fontanel, unless in skilled hands, is attended by a high risk. The absorption of substances injected intraperitoneally may, under certain circumstances, be greatly delayed. Moreover, in treatment of disorders of the abdomen it is not advisable to use this route. Thus there is left a group of infants for whom infusion by the intramedullary route may be the only advisable resort. These considerations have led us to a trial of the merits of the intramedullary route for infusion of fluids in a group
Charge-control modeling of power bipolar junction transistors (2000)

This paper describes an improved lumped circuit model of power bipolar junction transistors (BJTs) that can predict the turn-off fall time to a greater accuracy than currently available models. Though the existing models simulate the storage time and delay time to a good accuracy, the fall time performance is neglected. This is because the existing models do not account for the charge decay due to recombination. The model presented in this paper is based on the charge dynamics of the device. The charge dynamics are explained in detail using simulation results from an advanced two-dimensional (2-D) device and circuit simulator. Based on a physical understanding of the charge dynamics, this model is implemented to incorporate the charge decay due to recombination to account for the current tail during turn-off. The lumped-circuit model is implemented in PSPICE using the existing quasisaturation model along with controlled sources. To validate the model, the device was subjected to hard- as well as soft-switching renditions (zero current switching and zero voltage switching). The modeled results are observed to have a good match with measured results.
Zement (2000)

Der Ursprung des Wortes „Zement“ ist bei den alten Römern zu finden. Ihre von den Griechen übernommene Technik des Bauens mit Gußmauerwerk — dem Vorläufer unseres heutigen Betons — bezeichneten sie mit „Opus Cementitium“. Das lateinische Wort caementum hängt mit caedere, d.h. schneiden oder brechen zusammen und bezeichnete ursprünglich behauene Natursteinquader, später dann Bruchstücke von Steinen und schloß schließlich noch Gesteinssplitter und Steinmehl sowie zerkleinerte Ziegelsteine und Ziegelmehl ein. Aus dem caementum der Römer wurde im Verlaufe der Zeit in Frankreich Cimentum und Ciment, in England Cement und in Deutschland Zyment, wobei bis zu Beginn des 19. Jahrhunderts darunter ausschließlich das aus Natursteinen und Ziegeln gewonnene Mehl verstanden wurde. Ein Begriffswandel setzte erst ein, als sich der Engländer James Parker bei der Suche nach einem hydraulischen Bindemittel im Jahre 1796 einen sogenannten Romanzement patentieren ließ. Hier wurde erstmals mit Zement das Bindemittel und nicht das Gesteins- oder Ziegelmehl bezeichnet.
Spectral efficiency of a multitone frequency hopping system for personal communication systems (2002)

Different spread spectrum techniques have been proposed for future mobile radio systems. The two main methods of spreading the spectrum have been to use either a direct sequence spreading or a frequency hopping spreading. The authors analyze an alternative multiple access scheme, multitune frequency hopping. The choice of frequencies is made randomly with the constraint that each frequency is not used more than once in each cell. With this random channel allocation one can avoid both frequency planning and intra-cell interference. Other advantages are frequency diversity, frequency interleaving and no problems regarding time dispersion. For a given minimum transmission quality constraint the authors define, a spectral efficiency measure. Further, they derive the spectral efficiency of the proposed system when a pilot tone MPSK modulation has been used. Even though they transmit a pilot tone for each used frequency, the resulting spectral efficiency of the proposed system compares favorably with other proposals for future mobile radio systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Moderation of skeletal muscle reperfusion injury by a sLe<sup>x</sup>-glycosylated complement inhibitory protein (2001)

The role of the sialyl Lewis(x) (sLe(x))-decorated version of soluble complement receptor type 1 (sCR1) in moderating skeletal muscle reperfusion injury, by antagonizing neutrophil endothelial selectin interaction and complement activation, is examined. Mice underwent 2 h of hindlimb ischemia and 3 h of reperfusion. Permeability index (PI) was assessed by extravasation of 125I-labeled albumin. Neutrophil depletion and complement inhibition with sCR1 reduced permeability by 72% (PI 0.81 +/- 0.10) compared with a 42% decrease (PI 1.53 +/- 0.08) observed in neutropenic mice, indicating that part of the complement-mediated injury is neutrophil independent. sCR1sLe(x) treatment reduced PI by 70% (PI 0.86 +/- 0.06), an additional 20% decrease compared with sCR1 treatment (PI 1.32 +/- 0.08). Treatment with sCR1sLe(x) 0.5 and 1 h after reperfusion reduced permeability by 63% (PI 0.09 +/- 0.07) and 52% (PI 1.24 +/- 0.09), respectively, compared with the respective decreases of 41% (PI 1.41 +/- 0.10) and 32% (PI 1.61 +/- 0.07) after sCR1 treatment. Muscle immunohistochemistry stained for sCR1 only on the vascular endothelium of sCR1sLe(x)-treated mice. In conclusion, sCR1sLe(x) is more effective than sCR1 in moderating skeletal muscle reperfusion injury.
Anonymous-Key Quantum Cryptography and Unconditionally Secure Quantum Bit Commitment (2006)

A new cryptographic tool, anonymous quantum key technique, is introduced that leads to unconditionally secure key distribution and encryption schemes that can be readily implemented experimentally in a realistic environment. If quantum memory is available, the technique would have many features of public-key cryptography; an identification protocolthat does not require a shared secret key is provided as an illustration. The possibility is also indicated for obtaining unconditionally secure quantum bit commitment protocols with this technique.