gebhart/patrepeval huggingface dataset:
Increased Presynaptic Protein Kinase C Activity and Glutamate Release in Rats with a Prenatally Induced Hippocampal Lesion (1997)

We have previously shown that protein kinase C (PKC) activity is up-regulated in nerve terminals of animals that have been subjected to targeted cellular ablation of cortical and hippocampal neurons by treatment with methylazoxymethanol (MAM), which results in impaired long-term potentiation (LTP) and cognitive deficit. In this study we investigated the consequences of increased membrane-bound PKC in the regulation of release of glutamate, the major excitatory transmitter involved in LTP. We show that nerve terminals of MAM-treated rats show higher PKC activity, as monitored by the in situ phosphorylation of B-50/GAP-43, in both basal and phorbol ester-stimulated conditions. In these animals, hippocampal nerve endings release a greater amount of glutamate than those of controls, both in basal conditions and when synaptosomes are stimulated with KCl or 3,4-diaminopyridine. The potentiation observed in MAM-treated rats was counteracted by the PKC blocker H-7 and the clostridial tetanus toxin. On the contrary, GABA release was not significantly up-regulated, either in basal or in depolarization-evoked conditions. Therefore our data show that the increase in synaptosomal PKC activity is paralleled by increased glutamate but not GABA release in this animal model. Whether this reflects specific up-regulation of membrane PKC activity in glutamatergic terminals or an alteration in the regulation of glutamate release remains to be determined.
Gene expression signature of parathion-transformed human breast epithelial cells (2007)

Environmental substances seem to be involved in the etiology of breast cancers. Many studies have found an association between human cancer and exposure to agricultural pesticides such as the organophosphorous pesticides. Parathion is a cholinesterase inhibitor that induces the hydrolysis of body choline esters, including acetylcholine at cholinergic synapses. The primary target of action in insects is the nervous system whereby pesticides inhibit the release of the enzyme acetylcholinesterase at the synaptic junction. Atropine is a parasympatholytic alkaloid used as an antidote to acetylcholinesterase inhibitors. The aim of this study was to determine the effect of parathion and atropine on cell transformation of human breast epithelial cells in vitro. These studies showed that parathion alone was able to induce malignant transformation of an immortalized human breast epithelial cell line, MCF-10F as indicated by increased cell proliferation, anchorage independency and invasive capabilities. There was also an increase in c-kit, Trio, Rho-A, Rac-3, EGFR, Notch-4, Dvl-2, Ezrin, beta catenin and mutant p53 protein expression in the parathion-treated cells. However, atropine significantly inhibited this increase. In a human cell cycle array of 96 genes, 13 of them were altered by parathion treatment. Among the genes affected were the cyclins, such as cyclin D3, the cyclin-dependent kinases (CDKs) such as CDK41 and the minichromosome maintenance deficient (MCM) MCM2 and MCM3. It is suggested that parathion influences human breast epithelial cell transformation and is an initiator factor in the transformation process in breast cancer.
Relationship Between Agriculture and Ecological Deterioration, Restoration and Reconstruction in Loess Plateau Areas of Northwest China (2002)

A comprehensive analysis was conducted on the current situation as well as historic succession process of and ecological conditions in Northwest China, in particular in the Loess Plateau, by means of a inter-disciplinary approach of ecology, agro-geohistory, and agronomy. It was concluded that the fundamental causes responsible for the ecological deterioration, signed by the poor agro-productivity and serious soil erosion, had been the extensive cropping system by ever-increasing reclamation on semi-drought slope land, where initiated a natural vegetation of brushy grasses with sparse trees, thus suitable only for animal husbandry. Based on an identification of specific actual status of China, several countermeasures of correctly dealing with the relationship between agricultural development and the ecological restoration and reconstruction were proposed, including to get breakthrough first in the transection area by means of the rational use of resources and the raising of agro-system productivity, to promoting water conservancy-type ecological agriculture through the radical shift of traditional production pattern, and the adoption of a policy of proper degree of grain self-reliance, as well as to construct livestock industry base in Northwest China.
A utility maximization approach to the design of unequal error protection with multilevel codes (2008)

The observation that different bit positions in a constellation typically have different error protection capabilities is utilized to design unequal error protection (UEP) with multilevel coding (MLC) in AWGN and fading channels. Both parallel independent decoding (PID) and multi-stage decoding (MSD) are considered. The design tool in this work is the symmetric information rate (SIR), which is well suited to the use of capacity-approaching component codes. This paper first formulates the UEP design as a utility maximization problem, and then considers some optimal UEP designs, including mapping, non-uniform constellation, bits grouping, and decoding order in MSD. Several exemplary utility functions are studied, corresponding to different application scenarios. The UEP design is especially beneficial in a slow fading channel, as it allows for a gradual performance degradation with the decreasing receive SNR. Average rate advantage is shown to quantify this gain.
Negotiating Order (1995)

This chapter first sets out the purpose of the book, which is to examine what community policing is. A key concern is whether there is anything distinctive in decision-making by community police. It then discusses a socio-legal perspective on community policing, policing in the community, policing in culture, community differentiation, and relief policing.
Enhancing the Drug Metabolism Activities of C3A— A Human Hepatocyte Cell Line—By Tissue Engineering Within Alginate Scaffolds (2006)

In this study, we investigated the applicability of C3A--a human hepatocyte cell line--as a predicting tool for drug metabolism by applying tissue-engineering methods. Cultivation of C3A cells within alginate scaffolds induced the formation of spheroids with enhanced drug metabolism activities compared to that of two-dimensional (2-D) monolayer cultures. The spheroid formation process was demonstrated via histology, immunohistochemistry, and transmission electron microscope (TEM) analyses. The C3A spheroids displayed multilayer cell morphology, characterized by a large number of tight junctions, polar cells, and bile canaliculi, similar to spheroids of primary hepatocytes. Spheroid formation was accompanied by a reduction in P-glycoprotein (Pgp) gene expression and C3A cell proliferation was limited mainly to cells on the spheroid outskirt. The 3-D constructs maintained a nearly constant cell number according to MTT assay. Drug metabolism by the two most important cytochrome p-450 (CYP) enzymes in human liver, CYP1A2 and CYP3A4, was tested using preferred drugs. With CYP1A2, 3-fold enhancement in activity per cell was seen for converting ethoxyresorufin to resorufin compared to C3A cell monolayers. The spheroids responded to the inducer beta-naphthoflavone and to the inhibitor furafylline of CYP1A2. Enhanced metabolizing activity of CYP3A4, measured by the amount 6beta-testosterone formed from testosterone, and that of the phase II enzyme glucuronosyltransferases (UGT) further indicated that the tissue-engineered C3A spheroids may provide an efficient experimental tool for predicting drug activities by these CYPs. Moreover, the maintenance of constant cell number, as well as the elevated hepatocellular functions and drug metabolism activities, suggest that the tissue-engineered C3A may be applicable in replacement therapies.
Unsupervised segmentation of textured images by pairwise data clustering (2002)

A novel approach to unsupervised texture segmentation is presented which is formulated as a combinatorial optimization problem known as pairwise data clustering with a sparse neighborhood structure. Pairwise dissimilarities between texture blocks are measured in terms of distribution differences of multi-resolution features. The feature vectors are based on a Gabor wavelet image representation. To efficiently solve the data clustering problem a deterministic annealing algorithm on the basis of a mean field approximation is derived. An application to collages of Brodatz-like microtexture is demonstrated. The adequacy of the proposed segmentation cost function is statistically validated. The deterministic annealing algorithm outperforms its stochastic variants in terms of quality and efficiency.
Design of isofrequency reconfigurable repeaters (2013)

The advances in the communications systems has brought new requirements and challenges in terms of compactness and efficient systems that looking for increase the signal coverage area. The reconfigurable antennas are a promising solution for the communication systems when looking to improve the channel capacity and/or to extend the signal coverage. The main advantages of the reconfigurable antennas are the capabilities to change their frequency, polarization and radiation beam steering at a low cost. The reconfigurable antennas can be designed to operate in a determined changing environment keeping good electromagnetic characteristics. The design of reconfigurable RF repeaters is a relevant application of this reconfigurable antenna principle. This thesis is devoted to study and propose new repeater architectures in which a set of reconfigurable parasitic elements as part of the repeater are used for reducing the electromagnetic coupling between the Rx and Tx antennas. It is shown that the use of the parasitic elements as a reconfigurable mechanism gives the flexibility to adapt the repeater electromagnetic characteristics to changing environments while keeping a good system performance. The determination of the minimum number of parasitic elements is an important parameter and it is determined by a modal analysis to define the minimum number of parasitic elements able to fulfill specific repeater electromagnetic characteristics. In order to validate the analytical results, different reconfigurable repeater prototypes controlled electronically are manufactured. A reconfigurable repeater prototype that is using eight reconfigurable parasitic elements has been designed for operating at different scatterer environments. The repeater reconfigurable capabilities are studied to evaluate the repeater performance in realistic indoor locations. Finally, in order to obtain a repeater with reconfigurable frequency isolation capabilities between the Rx and Tx antennas over a wide frequency range, a repeater prototype based on a pixeled layer as reconfigurable mechanism has been designed and measured.
Transduction and Oncolytic Profile of a Potent Replication-Competent Adenovirus 11p Vector (RCAd11pGFP) in Colon Carcinoma Cells (2011)

Replication-competent adenovirus type 5 (Ad5) vectors promise to be more efficient gene delivery vehicles than their replication-deficient counterparts, and chimeric Ad5 vectors that are capable of targeting CD46 are more effective than Ad5 vectors with native fibers. Although several strategies have been used to improve gene transduction and oncolysis, either by modifying their tropism or enhancing their replication capacity, some tumor cells are still relatively refractory to infection by chimeric Ad5. The oncolytic effects of the vectors are apparent in certain tumors but not in others. Here, we report the biological and oncolytic profiles of a replication-competent adenovirus 11p vector (RCAd11pGFP) in colon carcinoma cells. CD46 was abundantly expressed in all cells studied; however, the transduction efficiency of RCAd11pGFP varied. RCAd11pGFP efficiently transduced HT-29, HCT-8, and LS174T cells, but it transduced T84 cells, derived from a colon cancer metastasis in the lung, less efficiently. Interestingly, RCAd11p replicated more rapidly in the T84 cells than in HCT-8 and LS174T cells and as rapidly as in HT-29 cells. Cell toxicity and proliferation assays indicated that RCAd11pGFP had the highest cell-killing activities in HT29 and T84 cells, the latter of which also expressed the highest levels of glycoproteins of the carcinoma embryonic antigen (CEA) family. In vivo experiments showed significant growth inhibition of T84 and HT-29 tumors in xenograft mice treated with either RCAd11pGFP or Ad11pwt compared to untreated controls. Thus, RCAd11pGFP has a potent cytotoxic effect on colon carcinoma cells.
Studies in astronomical time series analysis. III - Fourier transforms, autocorrelation functions, and cross-correlation functions of unevenly spaced data (1989)

This paper develops techniques to evaluate the discrete Fourier transform (DFT), the autocorrelation function (ACF), and the cross-correlation function (CCF) of time series which are not evenly sampled. The series may consist of quantized point data (e.g., yes/no processes such as photon arrival). The DFT, which can be inverted to recover the original data and the sampling, is used to compute correlation functions by means of a procedure which is effectively, but not explicitly, an interpolation. The CCF can be computed for two time series not even sampled at the same set of times. Techniques for removing the distortion of the correlation functions caused by the sampling, determining the value of a constant component to the data, and treating unequally weighted data are also discussed. FORTRAN code for the Fourier transform algorithm and numerical examples of the techniques are given.
Automated Detection of Infant Holding Using Wearable Sensing (2019)

Physical contact is critical for children's physical and emotional growth and well-being. Previous studies of physical contact are limited to relatively short periods of direct observation and self-report methods. These methods limit researchers' understanding of the natural variation in physical contact across families, and its specific impacts on child development. In this study we develop a mobile sensing platform that can provide objective, unobtrusive, and continuous measurements of physical contact in naturalistic home interactions. Using commercially available motion detectors, our model reaches an accuracy of 0.870 (std: 0.059) for a second-by-second binary classification of holding. In addition, we detail five assessment scenarios applicable to the development of activity recognition models for social science research, where required accuracy may vary as a function of the intended use. Finally, we propose a grand vision for leveraging mobile sensors to access high-density markers of multiple determinants of early parent-child interactions, with implications for basic science and intervention.
Lithium Promotes Neuronal Repair and Ameliorates Depression-Like Behavior following Trimethyltin-Induced Neuronal Loss in the Dentate Gyrus (2014)

Lithium, a mood stabilizer, is known to ameliorate the stress-induced decrease in hippocampal neurogenesis seen in animal models of stress-related disorders. However, it is unclear whether lithium has beneficial effect on neuronal repair following neuronal damage in neuronal degenerative diseases. Here, we evaluated the effect of in vivo treatment with lithium on the hippocampal neuronal repair in a mouse model of trimethyltin (TMT)-induced neuronal loss/self-repair in the hippocampal dentate gyrus (such mice referred to as "impaired animals") [Ogita et al. (2005) J Neurosci Res 82: 609-621]. The impaired animals had a dramatically increased number of 5-bromo-2'-deoxyuridine (BrdU)-incorporating cells in their dentate gyrus at the initial time window (days 3 to 5 post-TMT treatment) of the self-repair stage. A single treatment with lithium produced no significant change in the number of BrdU-incorporating cells in the dentate granule cell layer and subgranular zone on day 3 post-TMT treatment. On day 5 post-TMT treatment, however, BrdU-incorporating cells were significantly increased in number by lithium treatment for 3 days. Most interestingly, chronic treatment (15 days) with lithium increased the number of BrdU-incorporating cells positive for NeuN or doublecortin in the dentate granule cell layer of the impaired animals, but not in that of naïve animals. The results of a forced swimming test revealed that the chronic treatment with lithium improved the depression-like behavior seen in the impaired animals. Taken together, our data suggest that lithium had a beneficial effect on neuronal repair following neuronal loss in the dentate gyrus through promoted proliferation and survival/neuronal differentiation of neural stem/progenitor cells in the subgranular zone.
A goal-driven auto-configuration tool for the distributed workflow management system mentorlite (2000)

The Mentor-lite prototype has been developed within the research project “Architecture, Configuration, and Administration of Large Workflow Management Systems” funded by the German Science Foundation (DFG). It has evolved from its predecessor Mentor [1], but aims at a simpler architecture. The main goal of Mentor-lite has been to build a light-weight, extensible, and tailorable workflow management system (WFMS) with small footprint and easy-to-use administration capabilities. Our approach is to provide only kernel functionality inside the workflow engine, and consider system components like history management and worklist management as extensions on top of the kernel. The key point to retain the light-weight nature is that these extensions are implemented as workflows themselves. The workflow specifications are interpreted at runtime, which is a crucial prerequisite for flexible exception handling and dynamic modifications during runtime. The interpreter performs a stepwise execution of the workflow specification according to its formal semantics. For each step, the activities to be performed by the step are determined and started. Mentor-lite supports a protocol for distributed execution of workflows spread across multiple workflow engines. This support is crucial for workflows that span large, decentralized enterprises with largely autonomous organizational units or even cross multiple enterprises to form so-called “virtual enterprises”. A communication manager is responsible for sending and receiving synchronization messages between the engines. In order to guarantee a consistent global state even in the presence of site or network failures, we have built reliable message queues using the CORBA Object Transaction Services. For administration, Mentor-lite provides a Java-based workbench for workflow design, workflow partitioning across multiple workflow servers, and a Java-based runtime monitoring tool.
World Assize: Yes or No? (1954)

The Bulletin in the February 1954 issue published an article by Dr. Lewis Mumford in which he called for a World Assize of Scientific Knowledge on the effects of atomic and hydrogen bombs. Dr. Mumford believes that the initial responsibility rests with the men who created the nuclear weapons. His article elicited comment from Dr. Frederick Reines, Los Alamos, and Dr. Katherine Way, Washington, D.C. The exchange of letters between Dr. Reines and Dr. Mumford as well as the comments by Dr. Way are printed below.
Inter-injection locking — a novel phase control technique for monolithic phased arrays (1987)

A novel technique for phase control in millimeter-wave phased arrays has been demonstrated with a 10 GHz model. The main beam of a four-element array has been steered ±5° using only one phase shifter. The system's characteristics such as an effective radiated power of 7.4 W, a sidelobe level 16 dB below the main beam, and adaptability to monolithic fabrication make this technique attractive for beam steering at millimeter wave frequencies.
Riluzole improves functional recovery after ischemia in the rat retina. (1999)

Riluzole acted in vivo as a potent neuroprotective agent against pressure-induced ischemia. Therefore, riluzole may be a major drug for use in protection against retinal injury.
X-band digital receiver for the New Horizons spacecraft (2004)

A low-power X-band digital uplink receiver has been developed by the APL for NASA's planned New Horizons mission to Pluto and the Kuiper Belt, which is scheduled to launch in January 2006 with a Pluto encounter as early as 2015. The uplink receiver provides X-band carrier tracking, command detection/demodulation, critical command decoding, ranging tone demodulation, and built-in radiometrics modes. The primary RF carrier tracking, command detection, and ranging requirements are similar to those of predecessor deep space RF systems, including both the small deep space transponder (SDST) and CONTOUR RF transceiver systems. Additional design requirements for radioscience compatibility and reduced power consumption led to a new design approach. The new receiver design makes use of digital processing techniques and revised system architecture to meet these new requirements, while at the same time enhancing performance and flexibility over predecessor systems. A 53% to 68% reduction in secondary power consumption over comparable predecessor systems has been achieved. This paper provides a detailed description of the new low-power digital receiver design.
Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge (1999)

We examined the ability of a live, attenuated deletion mutant of simian immunodeficiency virus (SIV), SIVmac239Delta3, which is missing nef and vpr genes, to protect against challenge by heterologous strains SHIV89.6p and SIVsmE660. SHIV89.6p is a pathogenic, recombinant SIV in which the envelope gene has been replaced by a human immunodeficiency virus type 1 envelope gene; other structural genes of SHIV89.6p are derived from SIVmac239. SIVsmE660 is an uncloned, pathogenic, independent isolate from the same primate lentivirus subgrouping as SIVmac but with natural sequence variation in all structural genes. The challenge with SHIV89.6p was performed by the intravenous route 37 months after the time of vaccination. By the criteria of CD4(+) cell counts and disease, strong protection against the SHIV89.6p challenge was observed in four of four vaccinated monkeys despite the complete mismatch of env sequences. However, SHIV89.6p infection was established in all four previously vaccinated monkeys and three of the four developed fluctuating viral loads between 300 and 10,000 RNA copy equivalents per ml of plasma 30 to 72 weeks postchallenge. When other vaccinated monkeys were challenged with SIVsmE660 at 28 months after the time of vaccination, SIV loads were lower than those observed in unvaccinated controls but the level of protection was less than what was observed against SHIV89.6p in these experiments and considerably less than the level of protection against SIVmac251 observed in previous experiments. These results demonstrate a variable level of vaccine protection by live, attenuated SIVmac239Delta3 against heterologous virus challenge and suggest that even live, attenuated vaccine approaches for AIDS will face significant hurdles in providing protection against the natural variation present in field strains of virus. The results further suggest that factors other than anti-Env immune responses can be principally responsible for the vaccine protection by live, attenuated SIV.
The first evidence for the generation of radicals and formation of electrically conducting molecular materials by protic doping of tetrathiafulvalenes (1994)

Protic acid doping of organic materials can be used to form conductive materials, see Figure. In an attempt to identify the mechanism of charge transfer in materials formed in this way, this first evidence is presented for the occurrence of radicals in the TTF + TTFH⊕ system (TTF us tetrathiafulvalene). magnified image