gebhart/patrepeval huggingface dataset:
Accurately Regulated Multiple Output ZVS DC-DC Converter (2006)

An accurately regulated multiple output ZVS dc-dc converter is proposed. The first and third outputs are regulated through the duty cycles of the two asymmetrical half bridge converters, while the second output is regulated through the phase shift of the two asymmetrical half bridge converters. ZVS is easily realized for all the main switches. Therefore this multiple output dc-dc converter can operate with higher switching frequency and higher efficiency. A 400V input, 48V/10A, 12V/5A, 5V/20A outputs prototype is built to verify its advantage. All the three output voltage regulations are less than 1%, and the efficiency at full load is 92.76%.
Optimization of Fluorinated Wettability Modifiers for Gas-Condensate Carbonate Reservoirs (2012)

Abstract Significant reduction in well productivity of gas-condensate reservoirs occurs owing to reduced gas mobility arising from the presence of condensate/water liquid phases around the wellbore. As wettability modifiers, fluorinated chemicals are capable of delivering a good level of oil and water repellency to the rock surface, making it intermediate gas-wet and alleviating such liquid blockage. The main objective of this experimental work has been to propose an effective chemical treatment process for carbonate rocks, which have received much less attention in comparison to sandstone rocks. Screening tests, including contact angle measurements and compatibility tests with brine, were performed using mainly anionic and nonionic fluorosurfactants. On positively charged carbonate surfaces the anionic chemicals were sufficiently effective to repel the liquid phase, whilst the nonionic chemicals showed an excellent stability in brine media. A new approach of combining anionic and nonionic chemical agents is proposed, to benefit from these two positive features of an integrated chemical solution. A number of low and high permeability carbonate cores have been successfully treated using chemicals selected through screening tests. Optimization of solvent composition and filtration of the solution before injecting chemicals into the core proved very effective in reducing/eliminating the risk of possible permeability damage due to deposition of large chemical aggregates on the rock surface. The chemical solution optimized in this study can be applied as an efficient wettability modifier for mitigating the negative impact of condensate/water banking in carbonate gas-condensate reservoirs.
Declarative techniques for model-driven business process integration (2005)

Business process integration and automation are among the most significant factors driving the information technology industry today. In addressing the manifold technology challenges of integration and automation, new standardization efforts aim at improving the interoperability of businesses by moving toward a declarative specification of business processes, that is, one which describes what a business process does and not how it is implemented. At the same time, Model Driven Architecture® focuses on improving the software-engineering methods with which business process solutions are implemented by separating the business or application logic from the underlying platform technology and representing this logic with precise semantic models. In this paper, we present an approach to the model-driven generation of programs in the Business Process Execution Language for Web Services (BPEL4WS), which transforms a graphically represented control-flow model into executable code by using techniques that originated in compiler theory. We discuss the underlying algorithms as well as general questions concerning the representation and analysis of model transformations. We study a declarative representation of transformation rules, where preconditions and postconditions are represented in the Object Constraint Language. By adopting a declarative approach, we pave the way for future automatic consistency checking of transformation rules and bidirectional reconciliation of evolving models.
Optimization of corrugated horn radiation patterns via a spline-profile (2002)

Corrugated horns are widely used as feeds for reflector antennas [1] or as direct radiators, as in global earth illumination from a satellite [2, 3] or as source antennas in an anechoic chamber. Shaping the radiation pattern of a corrugated horn is mainly done by shaping the profile [4-6] to the required aperture dimension, and to a lesser extent, for wideband applications, by using a mode-converter [7-9] tuned to the design frequency.
Temporal relation of antigenaemia and loss of antibodies to core antigens to development of clinical disease in HIV infection. (1987)

A total of 276 sequential serum samples from 34 men with antibodies to the human immunodeficiency virus (HIV) followed up for two to seven years were analysed for HIV antigen and antibodies to the viral core and envelope proteins. Results were correlated with clinical outcome and CD4 T lymphocyte count. Both antigenaemia and the disappearance of antibodies to the core protein were associated with development of the acquired immune deficiency syndrome (AIDS) or AIDS related complex and depletion of CD4 cells. Thus AIDS or AIDS related complex developed in eight out of 16 patients with antigenaemia compared with one out of 18 patients without antigenaemia. Low counts of CD4 cells (less than 0.5 X 10(9)/l) were found in 14 of the 16 patients with antigenaemia and five of the 18 without antigenaemia. Nine patients seroconverted to HIV during the study; two of these developed antigenaemia 14 and 16 months after the estimated time of seroconversion. These results show that the late stages of HIV infection are characterised by increased production of antigen and a decrease in antibodies directed against the core protein. Antigenaemia indicates a poor prognosis; and as the antigen test is simple to do and interpret, it may therefore be useful for selecting patients for antiviral treatment.
Novel Recombinant Hepatitis B Virus Vectors Efficiently Deliver Protein and RNA Encoding Genes into Primary Hepatocytes (2013)

Hepatitis B virus (HBV) has extremely restricted host and hepatocyte tropism. HBV-based vectors could form the basis of novel therapies for chronic hepatitis B and other liver diseases and would also be invaluable for the study of HBV infection. Previous attempts at developing HBV-based vectors encountered low yields of recombinant viruses and/or lack of sufficient infectivity/cargo gene expression in primary hepatocytes, which hampered follow-up applications. In this work, we constructed a novel vector based on a naturally occurring, highly replicative HBV mutant with a 207-bp deletion in the preS1/polymerase spacer region. By applying a novel insertion strategy that preserves the continuity of the polymerase open reading frame (ORF), recombinant HBV (rHBV) carrying protein or small interfering RNA (siRNA) genes were obtained that replicated and were packaged efficiently in cultured hepatocytes. We demonstrated that rHBV expressing a fluorescent reporter (DsRed) is highly infective in primary tree shrew hepatocytes, and rHBV expressing HBV-targeting siRNA successfully inhibited antigen expression from coinfected wild-type HBV. This novel HBV vector will be a powerful tool for hepatocyte-targeting gene delivery, as well as the study of HBV infection.
Real-Time Four-dimensional Imaging of the Heart with Multi–Detector Row CT (2003)

An interactive four-dimensional (4D) visualizing system for the heart was developed by the authors. The system realizes high-resolution three-dimensional (3D) imaging with temporal resolution in a beating heart by using eight or more data sets reconstructed from multi-detector row computed tomography (MDCT) with a retrospective electrocardiograph-gated reconstruction algorithm. The motion of heart walls, papillary muscles, septa, and valves can now be observed in 4D multiplanar reformations (MPRs), as with sonography, while coronary arteries, coronary sinuses, and cardiac veins can be analyzed during the optimal phase in 4D volume-rendering images, as with angiography. All parameters such as window width, window level, field of view, panning, tilt, thresholds, opacity, color, and segmentation function are completely interactive in 4D imaging. Two longitudinal views and one latitudinal view of a heart can be simultaneously visualized in the three relative 4D MPR views. These newly developed capabilities in viewing both 3D volume and temporal resolution data, functional data, and even multiphase data with registration add considerable diagnostic potential. The advent of this real-time 4D visualizing system has enhanced the capabilities of MDCT.
Evaluation of Antimicrobial Agents in the Rabbit Model of Endocarditis (1981)

The placement of a sterile polyethylene catheter in the heart of a rabbit results in nonbacterial thrombotic endocarditis characterized by an accumulation of fibrin strands, erythrocytes, and platelets that adhere to the endothelial surface. These elements form a nidus where a pathogen, when introduced by injection, lodges, multiples, and develops vegetations typical of infective endocarditis. In the rabbit model, endocarditis induced by Staphylococcus aureus or viridans group Streptococcus resembles the human disease in clinical and bacteriologic features and in response to antimicrobial therapy. The rabbit model thus affords a means of evaluating the therapy of endocarditis. The end points of therapeutic response are culture-negative vegetations and failure to relapse. On the basis of these criteria vancomycin was found to be more rapidly effective in curing an infection caused by a single strain of S. aureus than penicillin or cefazolin and as effective as a combination of penicillin and gentamicin.
Testimony Before the Subcommittee of the Senate Judiciary Committee (1974)

This testimony was originally published in the May 81, 1974 issue of Commonweal under the title " Protecting the Unborn." Reprinted with permission from Commonweal, 232 Madison Avenue, New York , N. Y. 10016. Dr. Ramsey is Harrington Spear Paine Professor of Religion at Princeton University. A scholar and teacher in the fields of religious ethics and social philosophy, he is also concerned with the serious moral issues emerging in the area of medical ethics.
Unsupervised pre-training for sequence to sequence speech recognition (2019)

This paper proposes a novel approach to pre-train encoder-decoder sequence-to-sequence (seq2seq) model with unpaired speech and transcripts respectively. Our pre-training method is divided into two stages, named acoustic pre-trianing and linguistic pre-training. In the acoustic pre-training stage, we use a large amount of speech to pre-train the encoder by predicting masked speech feature chunks with its context. In the linguistic pre-training stage, we generate synthesized speech from a large number of transcripts using a single-speaker text to speech (TTS) system, and use the synthesized paired data to pre-train decoder. This two-stage pre-training method integrates rich acoustic and linguistic knowledge into seq2seq model, which will benefit downstream automatic speech recognition (ASR) tasks. The unsupervised pre-training is finished on AISHELL-2 dataset and we apply the pre-trained model to multiple paired data ratios of AISHELL-1 and HKUST. We obtain relative character error rate reduction (CERR) from 38.24% to 7.88% on AISHELL-1 and from 12.00% to 1.20% on HKUST. Besides, we apply our pretrained model to a cross-lingual case with CALLHOME dataset. For all six languages in CALLHOME dataset, our pre-training method makes model outperform baseline consistently.
GraphH: A Processing-in-Memory Architecture for Large-Scale Graph Processing (2018)

Large-scale graph processing requires the high bandwidth of data access. However, as graph computing continues to scale, it becomes increasingly challenging to achieve a high bandwidth on generic computing architectures. The primary reasons include: the random access pattern causing local bandwidth degradation, the poor locality leading to unpredictable global data access, heavy conflicts on updating the same vertex, and unbalanced workloads across processing units. Processing-in-memory (PIM) has been explored as a promising solution to providing high bandwidth, yet open questions of graph processing on PIM devices remain in: 1) how to design hardware specializations and the interconnection scheme to fully utilize bandwidth of PIM devices and ensure locality and 2) how to allocate data and schedule processing flow to avoid conflicts and balance workloads. In this paper, we propose GraphH, a PIM architecture for graph processing on the hybrid memory cube array, to tackle all four problems mentioned above. From the architecture perspective, we integrate SRAM-based on-chip vertex buffers to eliminate local bandwidth degradation. We also introduce reconfigurable double-mesh connection to provide high global bandwidth. From the algorithm perspective, partitioning and scheduling methods like index mapping interval-block and round interval pair are introduced to GraphH, thus workloads are balanced and conflicts are avoided. Two optimization methods are further introduced to reduce synchronization overhead and reuse on-chip data. The experimental results on graphs with billions of edges demonstrate that GraphH outperforms DDR-based graph processing systems by up to two orders of magnitude and $5.12 {\times }$ speedup against the previous PIM design.
Constant-Size Structure-Preserving Signatures: Generic Constructions and Simple Assumptions. (2012)

This paper presents efficient structure-preserving signature schemes based on assumptions as simple as Decision-Linear. We first give two general frameworks for constructing fully secure signature schemes from weaker building blocks such as variations of one-time signatures and random-message secure signatures. They can be seen as refinements of the Even-Goldreich-Micali framework, and preserve many desirable properties of the underlying schemes such as constant signature size and structure preservation. We then instantiate them based on simple (i.e., not q-type) assumptions over symmetric and asymmetric bilinear groups. The resulting schemes are structure-preserving and yield constant-size signatures consisting of
Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study. (1987)

Forty-five patients with metastatic renal cell carcinoma were treated with coumarin (1,2-benzopyrone) and cimetidine. Patients received coumarin, 100 mg orally daily; cimetidine administration, 300 mg orally four times daily, was initiated on day 15 of therapy, and treatment with both drugs was continued until progression of disease. Three patients are too early to evaluate (on study less than or equal to 2 months with no change in tumor status). Objective responses (greater than or equal to 50% reduction in measurable disease) occurred in 14 of 42 evaluable patients (33.3%) (the 95% confidence interval based on this rate is +/- 14.3%), with three complete responses and 11 partial responses (PR). Complete responses lasted 9.5, 4+, and 9.5+ months. The median duration of response for the PR group was 5 months (range, 4 to 21+ months). Twelve patients experienced stabilization of disease ranging from 4 to 16.5+ months. No response was seen in 16 patients. There was no symptomatic, hematologic, or chemical (organ dysfunction) toxicity among the 45 patients treated. Coumarin and cimetidine appear to be safe and active agents in the treatment of metastatic renal carcinoma. Further studies are required to determine the optimal dose and scheduling of these agents.
Amorphous Silicon Photodetectors for Silicon Based Optical Waveguides (1997)

In this work performances of amorphous silicon photodetectors used to sense the light guided in Oxidised Porous Silicon Waveguides (OPSWG) are presented.\n\nWe have developed an original technology to fabricate silicon oxide channel waveguides on monocrystalline silicon wafers, consisting of selective anodization followed by thermal process. Due to the peculiar fabrication process waveguides are placed just under the surface of the silicon wafer. a-Si:H film has been grown on the top of the waveguide by a low temperature (PECVD) process, then aluminum contacts have been formed by standard lithography.\n\nBecause of the higher a-Si:H refractive index with respect to silicon oxide, the guided light is deviated in the film where a-Si:H substitutes the top air cladding. The high a-Si:H absorption coefficient in the visible range permits the efficient detection of guided light and conversion into an electrical signal.\n\nIn this paper different devices structures and coupling geometries between waveguide and detector are presented. I/V characteristics in the dark and under light excitation have been used to extrapolate equivalent electrical models, also reported in the paper.\n\nThe obtained results showed that the system OPSWG/a-Si:H sensor is suitable for optoelectronic applications.
Hit Identification of a Novel Dual Binder for <i>h‐telo/c‐myc</i> G‐Quadruplex by a Combination of Pharmacophore Structure‐Based Virtual Screening and Docking Refinement (2016)

It is well known that G-quadruplexes are targets of great interest for their roles in crucial biological processes, such as aging and cancer. Hence, a promising strategy for anticancer drug therapy is the stabilization of these structures by small molecules. We report a high-throughput in silico screening of commercial libraries from several different vendors by means of a combined structure-based pharmacophore model approach followed by docking simulations. The compounds selected by the virtual screening procedure were then tested for their ability to interact with human telomeric G-quadruplex folding by circular dichroism, fluorescence spectroscopy, and fluorescence intercalator displacement. Our approach resulted in the identification of a 13-[(dimethylamino)methyl]-12-hydroxy-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-8-one derivative as a novel promising stabilizer of G-quadruplex structures within the human telomeric and the c-myc promoter sequences.
Increased lethality of calmodulin antagonists and bleomycin to human bone marrow and bleomycin-resistant malignant cells. (1986)

The effect of bleomycin and calmodulin antagonists on human cells was studied using a clonogenic assay. A 1-h exposure to nontoxic concentrations of the calmodulin antagonists melittin (0.5 microM), pimozide (5 microM), and chlorpromazine (20 microM) increased the lethality of bleomycin to human ovarian carcinoma cells (SK-OV). No increase was seen with chlorpromazine sulfoxide, which lacks calmodulin antagonistic activity. Maximum enhancement of bleomycin lethality by calmodulin antagonists was seen when the antagonist was present simultaneously with bleomycin rather than before or after bleomycin. The cytotoxicity of bleomycin to A-253 head and neck squamous carcinoma cells, which were 10-fold more sensitive to bleomycin alone compared to SK-OV cells, was not markedly altered by the presence of 20 microM chlorpromazine. Chlorpromazine, melittin, or pimozide also increased the toxicity of bleomycin to human granulocyte/macrophage and erythroid stem cell colonies. These results demonstrate that calmodulin antagonists can significantly increase the lethality of bleomycin to some but not all human tumor cells and that nonmalignant hematological human cells may also be affected by this combination.
Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney (2006)

Cinnamaldehyde, a food flavour, has a high potential for human consumption in India. In this study, we evaluated the effect of cinnamaldehyde on the antioxidant status of the rat kidney. Rats were given cinnamaldehyde orally by gavage at dose levels of 2.14, 6.96, 22.62 and 73.5 mg/kg body weight/day for the period of 10, 30 and 90 days. The non-enzymatic antioxidants ascorbic acid, alpha-tocopherol and reduced glutathione were decreased while the antioxidant enzymes, superoxide dismutase, glutathione peroxidase and glutathione-s-transferase were increased. Catalase was decreased and thiobarbituric acid-reactive substances were increased only in the kidney of rats treated with cinnamaldehyde at the dose level of 73.5 mg/kg body weight/day during an exposure period of 90 days and not in the kidney of other cinnamaldehyde-treated rat groups. Thus, cinnamaldehyde has an effect on the antioxidant status of rat kidney and its effect is time- and dose-dependent.
Effects of &lt;i&gt;Bacillus subtilis&lt;/i&gt; KN-42 on Growth Performance, Diarrhea and Faecal Bacterial Flora of Weaned Piglets (2014)

This research focused on the effects of different doses of Bacillus subtilis KN-42 on the growth performance, diarrhea incidence, faecal bacterial flora, and the relative number of Lactobacillus and Escherichia coli in faeces of weaned piglets to determine whether the strain can serve as a candidate antimicrobial growth promoter. A total of 360 piglets (initial body weight 7.14±0.63 kg) weaned at 26±2 days of age were randomly allotted to 5 treatment groups (4 pens per treatment with 18 pigs per pen) for a 28-day trial. Dietary treatments were basal diet without any antimicrobial (negative control; NC), basal diet supplemented with 120 mg/kg feed of neomycin sulfate (positive control; PC) and basal diet supplemented with 2×10(9) (L), 4×10(9) (M) and 20×10(9) (H) CFU/kg feed of B. subtilis KN-42. During the overall period, average daily gain and feed efficiency of piglets were higher in groups PC, M, and H than those in group NC (p<0.05), and all probiotics and antibiotics groups had a lower diarrhea index than group NC (p<0.05). The 16S rDNA gene-based methods were used to analyze faecal bacterial flora on day 28 of experiment. The result of denaturing gradient gel electrophoresis analysis showed that supplementation of B. subtilis KN-42 to the diet changed the bacterial communities, with a higher bacterial diversity and band number in group M than in the other four groups. Real-time polymerase chain reaction analysis showed that the relative number of Lactobacillus were higher in groups PC and H than in group NC (p<0.05), and the supplemented B. subtilis KN-42 to the diet also reduced the relative number of E. coli (p<0.05). These results suggest that dietary addition of B. subtilis KN-42 can improve the growth performance and gastrointestinal health of piglets.
Effects of harmaline on ion transport and oxygen consumption by the bovine tracheal epithelium. (1986)

The alkaloid harmaline is known to affect various membrane transport systems. This study examines the action of the drug on the short-circuit current (I0) and on the oxidative metabolism (Jr) in the tracheal epithelium of the cow. In this tissue I0 corresponds to the sum of two active transports: Na+ is absorbed and Cl- is secreted by a process based on the activity of the Na+ pump. A well defined relationship has been previously demonstrated between these active transports and the rate of O2 consumption (Schoenenweid et al., 1984 b). Low concentrations of harmaline (10(-6) to 5.10(-6) M) induced a small stimulation of I0. In contrast, larger concentrations (between 5.10(-5) and 10(-3) M) yielded a dose-related inhibition of I0, with an apparent concentration yielding 50% of maximal effect of 7.1.10(-4) M and maximal effect approaching 100%. The action was fully reversible after removal of the drug. The measurements of the fluxes of 22Na and 36Cl revealed that harmaline at a concentration of 8.10(-4) M, which decreased the I0 by 74 +/- 1% (n = 23), diminished both Na+ and Cl- transports, by 81 and 52%, respectively. The time course of I0 decay following the administration of harmaline was made of three components, with half-times of 0.34, 2.2 and 15.2 min. The time course was not appreciably modified when Cl- secretion was abolished with furosemide. Although harmaline, 10(-3)M, inhibited markedly I0, it did not modify Jr significantly. In contrast, when K+ in the incubation solution was omitted, both Ji and Jr were lowered.(ABSTRACT TRUNCATED AT 250 WORDS)