gebhart/patrepeval huggingface dataset:
Synthesis and antitumor activity of novel α‐aminophosphonates from diterpenic dehydroabietylamine (2008)

Abstract A series of novel α‐aminophosphonates were synthesized from diterpenic dehydroabietylamine, and their structures were characterized by IR, 1 H NMR, and 31 P NMR spectroscopy. Their antitumor activities against SMMC7721 liver cancer cells were evaluated by the MTT method. Compounds 4 and 6 exhibited higher activities even at very low concentrations, and the inhibition ratios reached 75% and 79% at 0.1 µM, respectively. The inhibition ratio of compound 9 reached 99% after 72‐h incubation. α‐Aminophosphonates with a fluorine atom and a nitro group fused to the benzene ring exhibited higher activities. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:512–516, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20471
Task-Oriented Generation of Visual Sensing Strategies. (1996)

In vision-guided robotic operations, vision is used for extracting necessary information for achieving the task. Since visual recognition is usually performed with limited resources, visual sensing strategies should be planned so that only necessary information is obtained efficiently. This paper describes a method of generating visual sensing strategies for assembly tasks based on knowledge of the task to be performed. The generation of the appropriate visual sensing strategy entails knowing what information to extract, where to get it and how to get it. This is facilitated by the knowledge of the task, which describes what objects are involved in the operation, and how they are assembled.In the proposed method, using the task analysis based on face contact relations between objects, necessary information for the current operation is first extracted. Then, visual features to be observed are determined using the knowledge of the sensor, which describes the relationship between a visual feature and information to be obtained. Finally, feasible sensing strategies are evaluated based on the predicted success probability, and the best one is selected. Our method has been implemented using a laser range finder as the sensor. Experimental results show the feasibility of the method, and point out the importance of task-oriented evaluation of sensing strategies.
Per Hop Behaviors Based on Dynamic Packet State (2002)

Molecular characterization of infectious mouse mammary tumor viruses (MMTVs) has been hampered due to the problem of cloning a full-length exogenous virus into a plasmid. The present report describes our strategy for obtaining a full-length clone of an exogenous MMTV from a mouse mammary tumor that arose spontaneously in a wild Chinese mouse free of endogenous MMTV and shows that the cloned virus (JYG-MMTV) is expressed in rat RBA cells. Four-week-old C58/J x CBA/CaJ female mice, free of both endogenous and exogenous MMTVs, were injected with virus-secreting RBA cells. The progeny of these mice were bred, and their offspring were tested for the presence of MMTV. These third-generation mice were found to actively produce MMTV that was shed in their milk and transmitted to their offspring. The virus was detected not only in the mammary glands of these young mice, but also in their spleens and bone marrow. These results suggest that our plasmid-cloned exogenous JYG-MMTV is infectious. This virus can now be used effectively in manipulating the various genes of JYG-MMTV and other MMTV strains to understand their structure/function relationships.
Clustered gases as a medium for efficient plasma waveguide generation (2006)

Clustered gas jets are shown to be an efficient means for plasma waveguide generation, for both femtosecond and picosecond generation pulses. These waveguides enable significantly lower on-axis plasma density (less than 10(18) cm(-3)) than in conventional hydrodynamic plasma waveguides generated in unclustered gases. Using femtosecond pump pulses, self-guided propagation and strong absorption (more than 70%) are used to produce long centimetre scale channels in an argon cluster jet, and a subsequent intense pulse is coupled into the guide with 50% efficiency and guided at above 10(17)W cm(-2) intensity over 40 Rayleigh lengths. We also demonstrate efficient generation of waveguides using 100 ps axicon-generated Bessel-beam pump pulses. Despite the expected sub-picosecond cluster disassembly time, we observe long pulse absorption efficiencies up to a maximum of 35%. Simulations show that in the far leading edge of the long laser pulse, the volume of heated clusters evolves to a locally uniform and cool plasma already near ionization saturation, which is then efficiently heated by the remainder of the pulse.
An Outside-Rail Opamp Design Relaxing Low-Voltage Constraint on Future Scaled Transistors (2007)

SUMMARY An opamp design with outside-rail output relaxing a lowvoltage constraint on future scaled transistors is presented. The proposed opamp realizes 3-V output swing without gate-oxide stress although implemented in a 1.8-V 0.18-µm standard CMOS process. The 3-V-output operation is experimentally verified. The outside-rail output design with scaled transistors shows area advantage over un-scaled and inside-rail design while keeping signal-to-noise ratio and gain bandwidth constant. The chip area is estimated to be 47% of the conventional opamp using a 0.35µm CMOS and about an order of magnitude smaller compared with the conventional inside-rail 0.18-µm CMOS design due to reduced capacitor area. The proposed design could be extended to n-tuple VDD operation and applied to circuits with a feed back loop such as gain stage and filters. The extendibility of n-tuple VDD operation and its application are discussed with simulation results.
Wi-Fi Walkman: A wireless handhold that shares and recommends music on peer-to-peer networks (2005)

The Wi-Fi walkman is a mobile multimedia application that we developed to investigate the technological and usability aspects of human-computer interaction with personalized, intelligent and context-aware wearable devices in peer-to-peer wireless environments such as the future home, office, or university campuses. It is a small handheld device with a wireless link that contains music content. Users carry their own walkman around and listen to music. All this music content is distributed in the peer-to-peer network and is shared using ad-hoc networking. The walkman naturally interacts with the users and users' interest with each other in a peer-to-peer environment. Without annoying interactions, it can learn the users' music interest/taste and consequently provide personalized music recommendation according to the current situated context and user's interest. © 2005 SPIE and IS&T.
Dissolution behavior and gastrointestinal absorption of dicumarol from solid dispersion systems of dicmarol-polyvinylpyrrolidone and dicumarol-.BETA.-cyclodextrin. (1983)

Solid dispersion systems of dicumarol-polyvinylpyrrolidone (PVP) and dicumarol-β-cyclodextrin (β-CD) were prepared by co-evaporation or freeze-drying of the drug-matrix mixture ammonium solution. Comparative studies were made on in vitro dissolution and in vivo absorption of the solid dispersion systems and dicumarol crystal powder. The dissolution rates of dicumarol were markedly increased in these solid dispersion systems in the pharmacopeial disintegration medium at pH 7.5. In vivo absorption studies were carried out in rabbits by measuring the plasma levels of dicumarol followng the oral administration of the solid dispersion systems and dicumarol crystal powder. The peak levels of the drug were observed at 4-6 h postadministration in the cases of the solid dispersion systems. On the other hand, they were observed at 2-12 h postadmini-stration in the case of dicumarol crystal powder. It appears that the modification of the dissolution characteristics of dicumarol by preparing the solid dispersion systems results in increased bioavailability of dicumarol.
Engineering of daidzein 3’-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450 (2012)

A cytochrome P450 (CYP) enzyme, 3'-daidzein hydroxylase, CYP105D7 (3'-DH), responsible for daidzein hydroxylation at the 3'-position, was recently reported. CYP105D7 (3'-DH) is a class I type of CYP that requires electrons provided through electron transfer proteins such as ferredoxin and ferredoxin reductase. Presently, we constructed an artificial CYP in order to develop a reaction host for the production of a hydroxylated product. Fusion-mediated construction with the reductase domain from self-sufficient CYP102D1 was done to increase electron transfer efficiency and coupling with the oxidative process. An artificial self-sufficient daidzein hydroxylase (3'-ASDH) displayed distinct spectral properties of both flavoprotein and CYP. The fusion enzyme catalyzed hydroxylation of daidzein more efficiently, with a k(cat)/K(m) value of 16.8 μM(-1) min(-1), which was about 24-fold higher than that of the 3'-DH-camA/B reconstituted enzyme. Finally, a recombinant Streptomyces avermitilis host for the expression of 3'-ASDH and production of the hydroxylated product was developed. The conversion that was attained (34.6%) was 5.2-fold higher than that of the wild-type.
Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status (2000)

Biological parameters influencing the response of human colorectal cancers (CRCs) to CPT-11, a topoisomerase 1 (top1) inhibitor, were investigated using a panel of nine CRCs xenografted into nude mice. CRC xenografts differed in their p53 status (wt or muf) and in their microsatellite instability phenotype (MSI+ when altered). Five CRC xenografts were established from clinical samples. All five had a functional p53, two were MSI+ and three were MSI-. Tumour-bearing nude mice were treated intraperitonealy (i.p.) with CPT-11. At 10 mg kg(-1) of CPT-11, four injections at 4-day intervals, four of the five xenografts responded to CPT-11 (growth delay of up to 10 days); the non-responder tumour was MSI-. At 40 mg kg(-1) of CPT-11, six injections at 4-day intervals, the five CRCs displayed variable but marked responses with complete regressions. In order to assess the role of p53 status in CPT-11 response, four CRC lines were used. HT29 cell line was MSI-/Ala273-mutp53, its subclone HT29A3 being transfected by wtp53. LoVo cell line was MSI+/wtp53, its subclone X17LoVo dominantly expressed Ala273-mutp53 after transfection. LoVo tumours (MSI+/mutp53) were more sensitive than X17LoVo (MSI+/mutp53. HT 29 tumours (MSI-Imutp53), were refractory to CPT-11 while HT29A3 tumours (MSI-/wtp53) were sensitive, showing that wtp53 improves the drug-response in these MSI- tumours. Levels of mRNA expression of top1, fasR, TP53 and mdr1 were semi-quantified by reverse transcription polymerase chain reaction. None of these parameters correlated with CPT-11 response. Taken together, these observations indicate that MSI and p53 alterations could be associated with different CPT-11 sensitivities; MSI phenotype moderately influences the CPT-11 sensitivity, MSI+ being more sensitive than MSI(-)CRC freshly obtained from patients, mutp53 status being associated with a poor response to CPT-11.
Confocal surface plasmon microscopy with pupil function engineering (2012)

Surface Plasmon microscopy can measure local changes of refractive index on the micron scale. Interferometric plasmon imaging delivers quantitative high spatial resolution sensitive to refractive index. In addition the so called V(z) method allows image contrast to be controlled by varying the sample defocus without substantially degrading spatial resolution. Here, we show how a confocal system provides a simpler and more stable alternative. This system, however, places greater demands on the dynamic range of the system. We therefore use a spatial light modulator to engineer the microscope pupil function to suppress light that does not contribute to the signal.
Effect of Gentian Violet, Corticosteroid and Tar Preparations in <i>Staphylococcus</i>-aureus-Colonized Atopic Eczema (1999)

Antibacterial therapy with gentian violet not only reduces S. aureus dramatically, but also reduces the severity of the eczema. Reduction of S. aureus after therapy with glucocorticosteroids and LCD seems to be secondary to improvement of the skin condition.
A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein (2012)

Two positively charged basic amino acids, arginine and lysine, are mostly exposed to protein surface, and play important roles in protein stability by forming electrostatic interactions. In particular, the guanidinium group of arginine allows interactions in three possible directions, which enables arginine to form a larger number of electrostatic interactions compared to lysine. The higher pKa of the basic residue in arginine may also generate more stable ionic interactions than lysine. This paper reports an investigation whether the advantageous properties of arginine over lysine can be utilized to enhance protein stability. A variant of green fluorescent protein (GFP) was created by mutating the maximum possible number of lysine residues on the surface to arginines while retaining the activity. When the stability of the variant was examined under a range of denaturing conditions, the variant was relatively more stable compared to control GFP in the presence of chemical denaturants such as urea, alkaline pH and ionic detergents, but the thermal stability of the protein was not changed. The modeled structure of the variant indicated putative new salt bridges and hydrogen bond interactions that help improve the rigidity of the protein against different chemical denaturants. Structural analyses of the electrostatic interactions also confirmed that the geometric properties of the guanidinium group in arginine had such effects. On the other hand, the altered electrostatic interactions induced by the mutagenesis of surface lysines to arginines adversely affected protein folding, which decreased the productivity of the functional form of the variant. These results suggest that the surface lysine mutagenesis to arginines can be considered one of the parameters in protein stability engineering.
Estimation of Hemodialysis Access Blood Flow Rates by a Urea Method Is a Poor Predictor of Access Outcome (1998)

Blood flow in peripheral arteriovenous fistulae and grafts as used for hemodialysis access can be derived from simultaneous measurements of 1) the amount of access recirculation (AR) induced by reversing the dialysis blood lines, and 2) the dialyzer blood flow rate (Qb). The hemodynamic monitor (HDM) uses magnetic principles to measure AR. The measurement is based on differential conductivity between arterial (A) and venous (V) blood flows in the dialysis blood tubing sets after the injection of hypertonic saline into the V line as a conductivity tracer. Access blood flow rates (Qa) derived from AR measurements by the HDM are predictive of access outcome. The measurement of AR is traditionally done from the comparison of urea levels simultaneously taken from the A and V blood lines and from the systemic circulation. Thus, the urea method can also be used to estimate access blood flow rates. The purpose of this study was to determine whether urea based Qa values are also predictive of outcome. Forty-one patients with arteriovenous fistulae (n = 25) or Gore-Tex grafts (n = 16) were studied by a standard protocol. The protocol involved temporarily reversing the A and V lines, taking three blood samples for urea estimation, performing an HDM recirculation test, and recording Qb as per the machine blood pump setting. The data allowed calculation of Qa by the HDM (Qa [HDM]) and urea (Qa [urea]) methods. Qa (HDM) was 1,177 +/- 887 ml/min (mean +/- standard deviation) and Qa (urea) 964 +/- 793 ml/min, a statistically significant difference (paired t-test p < 0.001). There was a significant linear correlation between the results (r = 0.94, p < 0.0001), but the regression equation also showed that Qa (urea) values were less than Qa (HDM). The influence of the Qa value on access outcome was determined after an 8 month follow-up. Nine of the 41 accesses were lost to clotting. Chi-square and discriminate analyses showed that Qa (HDM) significantly (p = 0.005) predicted access outcome, whereas Qa (urea) did not (p = 0.164). The specificity of a low Qa (HDM) in predicting access clotting was 0.78, compared with 0.62 for Qa (urea). The data show that although Qa can be estimated by the urea method, the finding of a low Qa (urea) is a poor predictor of access outcome and may lead to cost ineffective investigations.
Biomechanical Evaluation of Titanium, Biodegradable Plate and Screw, and Cyanoacrylate Glue Fixation Systems in Craniofacial Surgery (1998)

Choice of appropriate fixation after reduction of displaced bone fragments or advancement of osteotomized segments requires knowledge of the maximal force to which these segments can be subjected. The present study was performed to obtain a biomechanical comparison of a variety of resorbable fixation systems as an alternative to metal plates and screws. Sheep cadaver parietal bone segments were osteotomized and fixed with one of six methods of fixation: (A) titanium plates and screws consisting of (1) miniplates and 2.0-mm-diameter screws; (2) midface plates and 1.5-mm screws; (3) microplates and 1.0-mm screws; (B) resorbable systems consisting of combinations of butyl-2-cyanoacrylate glue and biodegradable polylactic acid/polyglycolic acid copolymer plates and 2.0-mm screws as follows: (1) direct glue fixation of segments; (2) resorbable plates fixed to bone segments with cyanoacrylate glue; (3) resorbable plates fixed with resorbable screws. Compression testing was performed upon bone segments advanced and fixed across a central gap, and distraction testing was performed on bone segments fixed in direct contact. Force to failure in both distraction and compression was significantly greater in bone segments fixed with titanium miniplates than with any other method of fixation. Segments fixed with plates and screws, either nonresorbable or resorbable, achieved stronger fixation in distraction than in compression for all plate sizes tested. Resorbable plate and screw fixation was as strong as standard titanium midface and microplating systems in distraction, and stronger than the latter techniques in compression. With compressive forces of relapse, fixation with glue and resorbable plates was as strong as standard titanium midface and microplating systems. However, with distractive forces of relapse, glue fixation of either the bone segments or resorbable plates was weaker than both titanium and resorbable alternatives in which plates and screws were used. These findings may have direct impact on the choice of fixation devices used to support osteotomized or fractured bone segments, which are subjected to persistent muscular and soft-tissue pull.
Metabolic Syndrome and Cognitive Function: A Population-Based Follow-Up Study in Elderly Women (2006)

In elderly women, metabolic syndrome may be an important contributor to worsening of memory, which is an essential part of mild cognitive impairment.
SYNTHESES WITH TRIARYLVINYLMAGNESIUM BROMIDES. PENTAARYLALLYL ALCOHOLS (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSYNTHESES WITH TRIARYLVINYLMAGNESIUM BROMIDES. PENTAARYLALLYL ALCOHOLSC. Frederick KoelschCite this: J. Am. Chem. Soc. 1932, 54, 8, 3384–3389Publication Date (Print):August 1, 1932Publication History Published online1 May 2002Published inissue 1 August 1932https://pubs.acs.org/doi/10.1021/ja01347a057https://doi.org/10.1021/ja01347a057research-articleACS PublicationsRequest reuse permissionsArticle Views141Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensor-based navigation control and calibration of a wafer-handling mobile robot (2002)

In this paper, the authors propose a mobile robot composed of a free-ranging automated guided vehicle and a manipulator with six degrees of freedom, which is mounted on the vehicle. In navigation in the semiconductor manufacturing line, the mobile robot utilizes a predefined map representing the route to move in the working area with clean class 1. The map and the information about the task to be performed is transmitted to the main controller of the mobile robot through R/F communication. In navigation, the mobile robot uses a fuzzy control algorithm based on data from the sonar sensors attached to both right and left sides of the vehicle to maintain a positioning accuracy within /spl plusmn/1 cm. The mobile robot automatically calibrates the setting position of the manipulator to calculate the exact destination point where the given task should be carried out. Then, the manipulator loads the equipment with wafer-carriers or unloads wafer-carriers from the equipment in the semiconductor manufacturing line. By the proposed navigation algorithm based on fuzzy control and the calibration algorithm of the manipulator, the mobile robot efficiently carries out a given task in a semiconductor manufacturing line.
Preparation and Enhanced Hydrostability and Hydrogen Storage Capacity of CNT@MOF-5 Hybrid Composite (2009)

Metal−organic frameworks (MOFs) are a rapidly growing class of microporous materials. Various MOFs with tailored nanoporosities have recently been developed as potential storage media for natural gases and hydrogen. However, wider applications have been limited because even atmospheric moisture levels cause MOF instability, and unexpectedly low H2 storage capacity, at 298 K. To overcome these problems, we synthesized a hybrid composite of acid-treated multiwalled carbon nanotubes (MWCNTs) and MOF-5 [Zn4O(bdc)3; bdc = 1,4-benzenedicarbocylate] (denoted MOFMC). In a successful synthesis, well-dispersed MWCNTs in dimethylformamide (DMF) were mixed with a DMF solution of zinc nitrate tetrahydrate and terephthalic acid. The MOFMCs obtained had the same crystal structure and morphology as those of virgin MOF-5, but exhibited a much greater Langmuir specific surface area (increased from 2160 to 3550 m2/g), about a 50% increase in hydrogen storage capacity (from 1.2 to 1.52 wt % at 77 K and 1 bar and from 0.3 to 0.61 wt % at 298 K and 95 bar), and much improved stability in the presence of ambient moisture.