gebhart/patrepeval huggingface dataset:
Ac as a tool for the functional genomics of rice (1999)

To examine whether the maize autonomous transposable element Ac can be used for the functional analysis of the rice genome, we used Southern blot analysis to analyze the behaviour of Ac in 559 rice plants of four transgenic families through three successive generations. All families showed highly active transposition of Ac, and 103 plants (18.4%) contained newly transposed Ac insertions. In nine of the 12 independent transpositions analyzed, their germinal transmission was detected. Partial sequencing of 99 Ac-flanking sequences revealed that 21 clones exhibited significant similarities with protein-coding genes in databases and four of them matched rice cDNA sequences. These results indicate preferential Ac transposition into protein-coding rice genes. To examine the feasibility of PCR-based screening of gene knockouts in rice Ac plants, we prepared bulked genomic DNA from the leaves of approximately 6000 rice Ac plants and pooled the DNA according to a three-dimensional matrix. Of 14 randomly selected genes, two gene knockouts were identified, and one encoding a rice cytochrome P450 (CYP86) gene was shown to be stably inherited to the progeny. Together, these results suggest that Ac can be efficiently used for the functional analysis of the rice genome.
Collagen meniscus implantation: a systematic review including rehabilitation and return to sports activity (2011)

Knee function, symptoms, and activity level generally improved following CMI use, but poor research report quality was common. Additional well-designed long-term prospective studies are needed to better determine knee osteoarthrosis prevention efficacy and appropriate patient selection.
Seamless 32×10 Gb/s transmission over 320 km of 1.55 μm dispersion-shifted fiber using wavelengths ranging from 1546 nm to 1587 nm (2003)

This paper demonstrates 32/spl times/10 Gbit/s transmission over 1.55 /spl mu/m dispersion-shifted fiber. The channels are seamlessly allocated from 1546 nm to 1587 nm. Wideband optical amplifiers employing distributed Raman amplification are used as in-line amplifiers.
Epitaxial LiTaO3 thin film by pulsed metalorganic chemical vapor deposition from a single precursor (1993)

Epitaxial LiTaO3 thin films were grown on (0001) sapphire in a low pressure chemical vapor deposition reactor of a new design, using lithium tantalum hexa-t-butoxide as the precursor. X-ray diffraction shows that the LiTaO3 c axis is normal to the sapphire surface. The x-ray pole figure and cross-section transmission electron microscopy diffraction show that the films were also in-plane oriented, with sapphire [101̄0] parallel to lithium tantalate [101̄0]. The refractive index of the film compares well with bulk values, over a wide wavelength range.
Natural autoantibody against apolipoprotein A-I. Detection and characterization of the monoclonal antibody established from normal unimmunized BALB/c mice. (1994)

During the course of studying the immunogenicity of soybean lipids, we observed frequent production of the mAbs that bind to apolipoprotein A-I (apoA-I) when spleen cells from unimmunized normal BALB/c mice were employed for fusion. Of the 986 colonies from six fusions, 38 (3.9% of the total) were directed against apoA-I and 13 mAbs (IgM) were established for further analysis. The following lines of evidence indicate that this family of mAb may form a novel family of natural autoantibodies against apoA-I: 1) The mAbs were shown to bind effectively to high density lipoprotein from various species, including BALB/c mouse, and immunoblotting analyses revealed that the mAbs bound specifically to the 28-kDa protein of high density lipoprotein. 2) The 28-kDa protein was purified to homogeneity and identified as apoA-I by amino acid sequence analyses and by its cross-reactivity with a xenogenic anti-apoA-I mAb (clone A/11). 3) Differing from the xenogenic anti-apoA-I mAb, the present mAb did not bind to native apoA-I, whereas an effective binding was observed only when the apoA-I had formed a complex with neutral lipids containing polyunsaturated fatty acids such as trilinoleoylglycerol and 5-cholesten-3 beta-ol 3-linoleate. 4) Sera from unimmunized BALB/c mice had readily detectable Abs against apoA-I and the majority of the serum autoantibodies were of the IgA and IgM isotype. 5) The anti-apoA-I mAbs displayed a functional heterogeneity in their reactivity with polyanionic substances and some of the mAbs established showed an extensive cross-reaction with polyanionic substances such as ssDNA and cardiolipin.
Patterns of cerebrospinal fluid pathology correlate with disease progression in multiple sclerosis (2001)

Multiple sclerosis is a chronic inflammatory and demyelinating disease of the CNS with, as yet, an unknown aetiology. Temporal profile, intensity and treatment responses are highly variable in multiple sclerosis suggesting pathogenetic heterogeneity. This hypothesis has been supported by histopathological studies disclosing at least four different subtypes of acute demyelinating lesions. Although stratification of multiple sclerosis patients into these categories would be extremely helpful for clinical studies, this approach is impractical as it requires brain biopsy. In this study we investigated CSF cytology from 60 multiple sclerosis patients by flow cytometry. We identified different patterns of CSF cytology, which were independent of immunological parameters in the peripheral blood. The most variable CSF parameter was the B cell to monocyte ratio, which remained stable during different phases of disease in selected patients. The ratio correlated with disease progression but not with disability or disease duration in a retrospective, consecutive analysis. A high ratio (predominance of B cells) was associated with more rapid disease progression, whereas a low ratio (predominance of monocytes) was found in patients with slower progression. Our study demonstrates the existence and potential clinical relevance of different CSF cytology patterns. We hypothesize that CSF cytology patterns may reflect the heterogeneity in the pathogenesis of multiple sclerosis.
A Self-Oscillating Control Scheme for a Boost Converter Providing a Controlled Output Current (2011)

Most switched mode power supplies provide a regulated voltage at their output. However, there are applications requiring a controlled current. Among others are battery chargers, test equipment for converters driven by solar cells, and LED drivers. This paper describes a dc-dc power converter realizing such a current source. The converter is based on a boost converter, supplied by a voltage source and acting as a current source. The boost converter can increase the output voltage above the input voltage. The converter provides a high control bandwidth based on a self-oscillating current loop. As additional practical features, soft start and output overvoltage limitation are included and described in this paper. The modulator, the control, and the power stage are described in detail and verified by the experiment.
Design of Diagnosable Iterative Arrays (1971)

One-and two-dimensional iterative arrays of identical cells are becoming more important in the design of digital systems using large-scale integrated circuits because of the advantages that they provide in design, fabrication, and testing. Since arrays containing hundreds or thousands of gates on one chip are now considered possible, the task of finding procedures for the testing of such arrays from their edges is of concern to both the users and the manufactures. The iterative nature of cellular arrays sometimes makes it possible to derive test schedules of reasonable length.
Reinforcement Learning, Fast and Slow (2019)

Deep reinforcement learning (RL) methods have driven impressive advances in artificial intelligence in recent years, exceeding human performance in domains ranging from Atari to Go to no-limit poker. This progress has drawn the attention of cognitive scientists interested in understanding human learning. However, the concern has been raised that deep RL may be too sample-inefficient - that is, it may simply be too slow - to provide a plausible model of how humans learn. In the present review, we counter this critique by describing recently developed techniques that allow deep RL to operate more nimbly, solving problems much more quickly than previous methods. Although these techniques were developed in an AI context, we propose that they may have rich implications for psychology and neuroscience. A key insight, arising from these AI methods, concerns the fundamental connection between fast RL and slower, more incremental forms of learning.
Enhanced Access Control with Semantic Context Hierarchy Tree for Ubiquitous Computing (2008)

s: In most ubiquitous applications involving ubiquitous hospital, security mechanisms supporting the context of users and systems has becoming a key issue. Access control systems have to make decisions with users' current security-relevant context, such as time, location, user activity, and other environmental information available when the access requests arrive. In ubiquitous contextaware access control systems, a query issued by an authorized user might not be resolved if context specified by policy does not match that specified in the query, as though the semantic similarity of both contexts is much close. In this paper, semantic context-aware access control (SCAC), is proposed, to solve the problem mentioned earlier. The proposed system fetches users' context and ontology from middleware, with which context hierarchies are built. Using the context hierarchies and reasoning rules extracted from relevant ontology, the proposed model can bridging the semantic gap between policy specific context and query specific context in ubiquitous application systems such as ubiquitous hospital management systems.
Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate (2001)

Altered renal function is an essential component of the pathophysiological process in preeclampsia. The kidneys play a significant part in the turnover of most low molecular weight substances such as creatinine, urate and cystatin C. The present work was undertaken to investigate if the serum levels of these components are altered in characteristic ways in preeclampsia, and can be used to assist in the diagnosis of this condition. The serum levels were therefore determined in samples from 100 healthy women at term as well as in 45 samples of patients with preeclampsia (diastolic blood pressure >90 mmHg; urinary albumin excretion >300 mgL(-1)). The levels of all three components were significantly higher in samples from preeclamptic patients with the mean+SD being 1.55+/-0.29 vs. 1.05+/-0.19 mg L(-1) for cystatin C, 70+/-23 vs. 56+/-9.7 micromol L(-1) for creatinine, and 413+/-128 vs. 305+/-61 micromol L(-1) for urate. Receiver operating characteristic analysis demonstrated that the serum level of cystatin C had a superior diagnostic accuracy for preeclampsia compared to those of serum urate and creatinine and that the diagnostic accuracy of serum urate was better than that of serum creatinine.
Relationships Between Serum Unsaturated Fatty Acids and Coronary Risk Factors Negative Relations Between Nervonic Acid and Obesity-Related Risk Factors (2005)

Relative increases in unsaturated fatty acids (USFA) in the diet are considered to exert beneficial effects on coronary risk factors (CRF). However, detailed analysis of the relationships between serum USFA and CRF are scanty and there is no report of the relationship between nervonic acid (NA) and CRF. The objective of the present study was to analyze the relationships between serum USFA and CRF. Body height and weight, blood pressure, fasting serum total cholesterol (TC), triacyl-glycerol (TG), HDL cholesterol (HDLc), fasting blood sugar (FBS), total fatty acid composition, leptin, and high-sensitivity C-reactive protein (CRP) were measured in 31 men (age, 41-78 years) and 11 women (age, 54-77 years). The relationships between serum USFA, and body mass index (BMI), leptin, systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, HDLc, FBS, and CRP were analyzed using multiple regression analysis. The final results were summarized using coronary risk factor scores (CRFS) in order to assess the correlations between USFA with CRF. Oleic acid (OA), linoleic acid (LA), and eicosapentaenoic acid (EPA) were positively related to coronary risk factors (total CRFS = 2, 3, and 4, respectively), while nervonic acid (NA) exerted negative effects on these risk factors (total CRFS = -6 ). It is concluded NA may have preventive effects on obesity-related metabolic disorders.
Translation Brownian Diffusion Coefficient of Large (Multiparticle) Suspended Aggregates (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTranslation Brownian Diffusion Coefficient of Large (Multiparticle) Suspended AggregatesPushkar Tandon and Daniel E. RosnerCite this: Ind. Eng. Chem. Res. 1995, 34, 10, 3265–3277Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/ie00037a013https://doi.org/10.1021/ie00037a013research-articleACS PublicationsRequest reuse permissionsArticle Views399Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
4,5-Cis Unsaturated α-GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses (2015)

The total synthesis of 4,5-cis unsaturated α-GalCer analogues was achieved, and their immune-response altering activity was assessed in vitro as well as in vivo in mice. Using glycosyl iodide as a glycosyl donor, construction of the sphingosine unit was shortened by four steps and single α-stereoselectivity was achieved in good yield (67%). With regard to the therapeutic use of α-GalCer, the novel analogues (1b and 1c) distinctly induced a Th1-biased cytokine response, avoiding induction of a contradictory response and overstimulation.
Unusual Localizations of Hydatid Disease (2003)

Hydatid disease is endemic in several Mediterranean countries, posing an important health problem for these countries. The hydatid cyst is characterized by cystic lesions with clear boundaries, which can be observed in all parts of the body. Approximately 70 % of hydatid cysts are situated in the liver, followed by the lung (25 %). The kidneys, spleen, bile ducts, mesentery, soft tissue and brain are less frequent sites. We investigated patients who were treated for hydatid disease in our departments in the last 5 years with respect to localization of the disease, symptoms, surgical intervention, length of hospitalization, diameters of the cyst, and classification by Gharbi. In this retrospective and descriptive study, 176 patients are evaluated who were treated for hydatid disease between 1995 and 1999 in our departments. Of these patients, 14 were included with localization other than in the liver and lungs. Fourteen of the patients diagnosed with unusually located hydatid disease were men, six were women. Their mean age was 41.6 +/- 20.8 years; the length of hospital stay was 7.07 +/- 0.4 days. Overall, 28.6 % of patients with unusually located hydatid cyst had recurrent disease. The time period since last cyst operation was 5.25 +/- 3.5 years. The mean cyst diameter was 96.5 +/- 54.5 mm. According to Gharbi's classification, three cases (21.4 %) of the unusually located hydatid cysts were type I, two (14.3 %) type II, and eight (57.1 %) type III. There was only one case of type IV and no cases of type V. Spleen and kidneys are the organs where hydatid disease is most frequently observed after the liver and lung. It can be observed in all parts of the body including the brain, peritoneum, mesenterium, choledochus, pancreas, bone and muscles. The type of treatment is determined by the localization and type of hydatid disease. Surgical treatment for splenic hydatid cysts is splenectomy. The functional kidney should be saved in non-communicable hydatid disease. Total excision is almost never possible; endocystectomy and drainage procedure should be preferred for hydatid disease of the brain, pancreas and choledochus. Chemotherapy is usually given because of the risk of recurrence; this medical treatment consists in albendazole and mebendazole administration for 3-6 months in the postoperative period.
Indexed experimental X-ray powder diffraction patterns of Tl <sub>0.5</sub> Pb <sub>0.5</sub> Sr <sub>2</sub> Ca <sub>2</sub> Cu <sub>3</sub> O <sub>x</sub> (Tl,Pb-1223) and TlSr <sub>2</sub> Ca <sub>2</sub> Cu <sub>3</sub> O <sub>x</sub> (Tl-1223) (1993)

Indexed experimental powder diffraction patterns of Tl,Pb-1223 and Tl-1223 are presented with a method of determining good cell parameters for the former awkward case where c/a almost exactly equals 4. For Tl,Pb-1223, a = 3.814±0.001 Å, c = 15.267±0.005 Å, for Tl-1223, a = 3.814±0.001 Å, c = 15.302±0.005 Å, both tetragonal, space group P4/mmm.
Introduction (1990)

EURATOM is the organisation which is today entrusted with the task of implementing nuclear safeguards in the European Community. The International Atomic Energy Agency (IAEA) also conducts its own safeguards verification activities in the territories of the Community Member States. But as a result of developments in the late 1960s and early 1970s, it is EURATOM which has the initial responsibility for ensuring effective safeguards implementation in this particular region.KeywordsMember StateInternational Atomic Energy AgencyNuclear WeaponNuclear IndustryNuclear SubmarineThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
The Small Terminase, gp16, of Bacteriophage T4 Is a Regulator of the DNA Packaging Motor (2009)

Tailed bacteriophages and herpes viruses use powerful molecular motors to translocate DNA into a preassembled prohead and compact the DNA to near crystalline density. The phage T4 motor, a pentamer of 70-kDa large terminase, gp17, is the fastest and most powerful motor reported to date. gp17 has an ATPase activity that powers DNA translocation and a nuclease activity that cuts concatemeric DNA and generates the termini of viral genome. An 18-kDa small terminase, gp16, is also essential, but its role in DNA packaging is poorly understood. gp16 forms oligomers, most likely octamers, exhibits no enzymatic activities, but stimulates the gp17-ATPase activity, and inhibits the nuclease activity. Extensive mutational and biochemical analyses show that gp16 contains three domains, a central oligomerization domain, and N- and C-terminal domains that are essential for ATPase stimulation. Stimulation occurs not by nucleotide exchange or enhanced ATP binding but by triggering hydrolysis of gp17-bound ATP, a mechanism reminiscent of GTPase-activating proteins. gp16 does not have an arginine finger but its interaction with gp17 seems to position a gp17 arginine finger into the catalytic pocket. gp16 inhibits DNA translocation when gp17 is associated with the prohead. gp16 restricts gp17-nuclease such that the putative packaging initiation cut is made but random cutting is inhibited. These results suggest that the phage T4 packaging machine consists of a motor (gp17) and a regulator (gp16). The gp16 regulator is essential to coordinate the gp17 motor ATPase, translocase, and nuclease activities, otherwise it could be suicidal to the virus.
Fashion coordinates recommender system using photographs from fashion magazines (2011)

Fashion magazines contain a number of photographs of fashion models, and their clothing coordinates serve as useful references. In this paper, we propose a recommender system for clothing coordinates using full-body photographs from fashion magazines. The task is that, given a photograph of a fashion item (e.g. tops) as a query, to recommend a photograph of other fashion items (e.g. bottoms) that is appropriate to the query. With the proposed method, we use a probabilistic topic model for learning information about coordinates from visual features in each fashion item region. We demonstrate the effectiveness of the proposed method using real photographs from a fashion magazine and two fashion style sharing services with the task of making top (bottom) recommendations given bottom (top) photographs.
Preparation, characterisation and evaluation of curcumin with piperine-loaded cubosome nanoparticles (2014)

These findings provide the reference to a preferable choice of the curcumin formulation and contribute to therapeutic application in clinical research.
Synthesis of Mesoporous Eu<sub>2</sub>O<sub>3</sub> Microspindles (2007)

Mesoporous Eu2O3 microspindles have been prepared by a facile solution process followed by subsequent heat treatment. By adding urea stepwise and varying the reaction time, the dimension of the Eu2O3 microspindles can be easily tuned from 250 × 100 nm to 900 × 400 nm. The products were characterized by X-ray diffraction, small-angle X-ray scattering, (high-resolution) transmission electron microscopy, scanning electron microscopy, N2 adsorption, and photoluminescence spectroscopy. The Eu2O3 samples exhibit a relatively broad pore-size distribution, and the wall of the pore is constructed by well-crystalline Eu2O3 nanocrystals with diameters of about 15 nm. A possible formation mechanism of the mesoporous microspindles was also discussed.
Recent trends and advances in UWB positioning (2009)

Since the ruling of the Federal Communications Commission (FCC) in the United States to open up the spectrum from 3.1-10.6 GHz for ultra wideband (UWB) applications in 2002, interest in the use of UWB for localization outside of military applications has skyrocketed. The multi-purpose nature of UWB for localization and also high or low data rate communication make it robust and attractive in many indoor applications including wireless sensor networks, medical body area networks (BANs), surgical navigation, etc. A push towards integrating UWB with Global Positioning Systems (GPS), wireless local area networks (WLANs), Wi-Fi, and inertial measurement units (IMUs) help to mitigate localization errors with redundancy and increase interoperability with existing technologies. A look at the current trends both in the research community and industry highlight future applications of UWB positioning and the technologies which will serve as the building blocks in these systems.