gebhart/patrepeval huggingface dataset:
Pgrmc1 (Progesterone Receptor Membrane Component 1) Associates with Epidermal Growth Factor Receptor and Regulates Erlotinib Sensitivity (2010)

Tumorigenesis requires the concerted action of multiple pathways, including pathways that stimulate proliferation and metabolism. Epidermal growth factor receptor (EGFR) is a transmembrane receptor-tyrosine kinase that is associated with cancer progression, and the EGFR inhibitors erlotinib/tarceva and tyrphostin/AG-1478 are potent anti-cancer therapeutics. Pgrmc1 (progesterone receptor membrane component 1) is a cytochrome b(5)-related protein that is up-regulated in tumors and promotes cancer growth. Pgrmc1 and its homologues have been implicated in cell signaling, and we show here that Pgrmc1 increases susceptibility to AG-1478 and erlotinib, increases plasma membrane EGFR levels, and co-precipitates with EGFR. Pgrmc1 co-localizes with EGFR in cytoplasmic vesicles and co-fractionates with EGFR in high density microsomes. The findings have therapeutic potential because a Pgrmc1 small molecule ligand, which inhibits growth in a variety of cancer cell types, de-stabilized EGFR in multiple tumor cell lines. EGFR is one of the most potent receptor-tyrosine kinases driving tumorigenesis, and our data support a role for Pgrmc1 in promoting several cancer phenotypes at least in part by binding EGFR and stabilizing plasma membrane pools of the receptor.
Integrated Mesoscopic Cooler Circuits (IMCCs) (1999)

Abstract This paper presents the design, fabrication approach, and initial results on the development of an active composite fabric comprising a system of energy-efficient micro-miniature vapor-compression heat pumps to form integrated mesoscopic cooler circuits (IMCCs). Wafer-scale microfabrication, traditional volume processes such as injection molding, and new layered fabrication techniques have been combined with a scale-efficient vapor-compression cycle. The resulting IMCC offers significant improvements in cooling efficiency over normal-scale refrigeration. The flexible polymer-based IMCC patches may be interconnected to form distributed fault-tolerant refrigeration circuits for a wide variety of applications. Potential applications include microclimate control for military, space, and fire fighting personnel, on-board/chip cooling of electronic devices, medical applications requiring highly localized and/or efficient temperature control, and automotive comfort control devices.
Systolic and diastolic time intervals in the critically ill patient (1991)

Both systolic and diastolic time intervals can be investigated noninvasively at the bedside by the thoracic electrical bioimpedance technique to provide a better understanding of left heart function.
Design and optical characterization of a large continuous phase plate for Laser Integration Line and laser Megajoule facilities (2003)

For development of the French Laser Integration Line and the Laser Megajoule, we describe the design and the control of a first 383 mm × 398 mm continuous phase-plate prototype. Extensively used in laser fusion facilities for beam smoothing, this optical component was manufactured by deep etching onto a fused-silica substrate, which led to a phase plate engraved directly onto fused silica, with which good optical performance could be achieved. We demonstrate good agreement between the desired simulated component and the manufactured component in terms of focal spot shape. This demonstration was performed by both interferometric and photometric measurements.
Revision Functional Endoscopic Sinus Surgery (2002)

Functional endoscopic sinus surgery (FESS) has recently become a popular procedure for treating chronic sinusitis. However, there is a 2% to 24% rate of primary FESS failure. Revision functional endoscopic sinus surgery (RESS) is indicated for patients who remain symptomatic after primary FESS and optimal medical therapy have failed. A retrospective study was conducted on all patients who underwent RESS in our department between April 1988 and March 1998. During this period, FESS was performed 1,227 times to treat chronic sinusitis; among those procedures, 142 were RESS. Complications occurred in 14 RESS procedures (9.9%). After RESS, 65% patients had improved. In this study, we concluded that although RESS is more difficult than primary FESS because of distorted or missing anatomic landmarks, complications did not increase with RESS if meticulous surgical procedures were performed. However, the 65% improvement rate with RESS was lower than that of primary FESS.
Sulfanilamide Derivatives. II (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfanilamide Derivatives. IIRoger. Adams, P. H. Long, and Allene. JeanesCite this: J. Am. Chem. Soc. 1939, 61, 9, 2346–2349Publication Date (Print):September 1, 1939Publication History Published online1 May 2002Published inissue 1 September 1939https://pubs.acs.org/doi/10.1021/ja01878a023https://doi.org/10.1021/ja01878a023research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
1-ether-linked phosphoglycerides. Major endogenous sources of arachidonate in the human neutrophil. (1988)

This study has quantitated changes in the content of labeled and unlabeled arachidonate of neutrophil phosphoglyceride classes and subclasses during cell activation with ionophore A23187. The predominant pools of endogenous arachidonate in the resting neutrophil were found in ethanolamine (68%)-, choline (19%)-, and inositol (12.0%)-containing glycerolipids. Upon stimulation, endogenous arachidonate was lost from primarily ethanolamine (PE) greater than choline (PC) greater than inositol (PI)-linked phosphoglycerides. Released leukotriene B4 and 20-hydroxyleukotriene B4 accounted for 10-35% of the total arachidonate lost from all phosphoglyceride classes. In contrast to the mass loss, ionophore induced a decrease of labeled arachidonate from primarily PC and PI. In the resting neutrophil, 66% of the total arachidonate in PC was found in the 1-alkyl-linked fraction. Furthermore, loss of endogenous arachidonate from 1-alkyl-2-arachidonoyl sn-glycero-3-phosphocholine accounted for 62% of the decrease of arachidonate from choline-linked phosphoglycerides. In contrast, 60% of the release of labeled arachidonate from PC subclasses originated from 1-acyl molecular species. 1-Alk-1'-enyl-2-acyl-sn-glycero-3-PE contained 71% of the arachidonate in ethanolamine-linked phosphoglycerides and was the major PE subclass which was degraded during neutrophil activation with ionophore A23187. These findings demonstrate that human neutrophils contain large ether-linked stores of arachidonate and the capacity to mobilize these stores. In addition, this study points out major discrepancies between using mass or label to determine sources of arachidonate for eicosanoids.
Modes of low-pressure dual-frequency (27/2 MHz) discharges in hydrogen (2008)

This paper studies the modes of dual-frequency (high-frequency (HF)/low-frequency (LF)) low-pressure discharges. The dual-frequency discharges are shown to burn in one of three possible modes. At small LF voltages the first mode is observed, i.e. the HF discharge perturbed by the LF voltage. The second mode, i.e. the combined discharge, exists in the presence of intense ionization in the sheaths, when the LF voltage exceeds some critical value. The third mode (the LF discharge perturbed by an HF field) is observed when a small HF voltage is applied to the burning LF discharge. The range of parameters within which the first mode of the combined discharge may be extinguished by the LF voltage increase is shown to be limited by the HF discharge extinction curve from the low-pressure side as well as the lowest HF voltage for the transition of the discharge from the first mode to the second one.
A meta-search method reinforced by cluster descriptors (2002)

A meta-search engine acts as an agent for the participant search engines. It receives queries from users and redirects them to one or more of the participant search engines for processing. A meta-search engine incorporating many participant search engines is better than a single global search engine in terms of the number of pages indexed and the freshness of the indexes. The meta-search engine stores descriptive data (i.e., descriptors) about the index maintained by each participant search engine so that it can estimate the relevance of each search engine when a query is received. The ability for the meta-search engine to select the most relevant search engines determines the quality of the final result. To facilitate the selection process, the document space covered by each search engine must be described not only concisely but also precisely. Existing methods tend to focus on the conciseness of the descriptors by keeping a descriptor for a search engine &apos;s entire index. This paper proposes to cluster a search engine&apos;s document space into clusters and keep a descriptor for each cluster. We show that cluster descriptors can provide a finer and more accurate representation of the document space, and hence enable the meta-search engine to improve the selection of relevant search engines. Two cluster-based search engine selection scenarios (i.e., independent and high-correlation) are discussed in this paper. Experiments verify that the cluster-based search engine selection can effectively identify the most relevant search engines and improve the quality of the search results consequently. 1
A Survey on Millimeter-Wave Beamforming Enabled UAV Communications and Networking (2021)

Unmanned aerial vehicles (UAVs) have found widespread commercial, civilian, and military applications. Wireless communication has always been one of the core technologies for UAV. However, the communication capacity is becoming a bottleneck for UAV to support more challenging application scenarios. The heavily-occupied sub-6 GHz frequency band is not sufficient to meet the ultra high-data-traffic requirements. The utilization of the millimeter-wave (mmWave) frequency bands is a promising direction for UAV communications, where large antenna arrays can be packed in a small area on the UAV to perform three-dimensional (3D) beamforming. On the other hand, UAVs serving as aerial access points or relays can significantly enhance the coverage and quality of service of the terrestrial mmWave cellular networks. In this paper, we provide a comprehensive survey on mmWave beamforming enabled UAV communications and networking. The technical potential of and challenges for mmWave-UAV communications are presented first. Then, we provide an overview on relevant mmWave antenna structures and channel modeling. Subsequently, the technologies and solutions for UAV-connected mmWave cellular networks and mmWave-UAV ad hoc networks are reviewed, respectively. Finally, we present open issues and promising directions for future research in mmWave beamforming enabled UAV communications and networking.
Bacterial Synthesis of Nucleotides (1964)

The distribution of nucleoside phosphotransferase activities in bacteria was studied in the acidic reaction mixture containing HxR and a phosphate compound such as p-NPP, and the activities were found to be distributed in various kinds of bacteria, most of which are grouped in Gram-negative bacteria. The bacteria which can synthesize nucleotides by their nucleoside phosphotransferases were divided into two groups, depending on the kind of synthesized nucleotide isomers and the donor specificity. The bacteria which were characterized to catalyze mainly the phosphorylation at 5'-position of nucleoside were found in such genera as Pseudomonas, Alcaligenes, Achromobacter, Flavobacterium, Serratia and Staphylococcus, while the bacterial strains assigned to such genera as Aeromonas, Escherichia, Aerobacter, Proteus and Salmonella were characterized to predominantly catalyze the phosphorylation at 3'(& 2')-position. When the nucleotides were used as phosphate donors, their phosphate group was specifically transferred to the same position of the nucleotide which were produced by the bacteria, either in the intact cell system or in the cell-free systems. These specificities of nucleoside phosphotransferase were considered to be correlated with the classification of these bacteria.
Urinary markers for bladder cancer (2013)

Bladder cancer has the fifth highest incidence of all malignancies in the United States, with a propensity to recur, requiring lifelong surveillance after diagnosis. Urinary markers of disease have been of extreme interest in this field in an effort to simplify surveillance schedules and improve early detection of tumors. Many markers have been described, but most remain investigational. However, some markers have undergone clinical trials and are approved for clinical use. In this review, urinary markers and their application for screening and surveillance of bladder cancer are discussed.
Colorectal cancer in patients with inflammatory bowel disease: Can we predict risk? (2012)

The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), may be complicated by colorectal cancer (CRC). In a recent population-based cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of observation. The overall risk of CRC among patients with UC and CD was comparable with that of the general population. However, patients diagnosed with UC during childhood or as adolescents, patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased risk. In this commentary, we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD patients. Further advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated CRC. The ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic IBD. The challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD patients. The achieved knowledge may also be relevant for other inflammation-associated cancers.
NADH fluorimetry and diffuse reflectance spectroscopy on rat heart (1993)

The ability to assess the adequacy of oxygen delivery by the circulation to the mitochondria in tissue is essential in surgery, intensive care and anaesthesia. Furthermore it has become increasingly clear that it is no longer sufficient to measure global oxygen delivery and consumption as indicators of metabolic requirements but that knowledge about local oxygenation is needed. This is due to the redistribution of oxygen delivery and consumption between and even within the different organs. The success of the recently introduced tonometry, using splanchnic oxygenation instead of global oxygen parameters, as a guide to therapy in critical care [Fiddian-Green '87, Guterriez '92] is witness to the importance of the need to obtain information about the course of oxygen to tissue at microcirculatory and even mitochondrial level.
Analog 3-D Neuroprocessor for Fast Frame Focal Plane Image Processing (1995)

A particularly challenging neural network application requiring high-speed and intensive image processing capability is target acquisition and discrimination. It requires spatio-temporal recognition of point and resolved targets at high speeds. A reconfigur able neural architecture may discriminate targets from clutter or classify targets once resolved. By mating a 64 x 64 pixel array infrared (IR) image sensor to a 3-D stack (cube) of 64 neural-net ICs along respective edges, every pixel would directly input to a neural network, thereby processing the infor-mation with full parallelism. Being mated to the infrared sensor array, the cube would operate at 90°K temperature with <250 nanosecond signal processing speed and a low power consumption of only -2 watts. For low power and compactness in hardware, the emphasis has been on parallelism and analog signal processing. A versatile reconfigurable circuit is presented that offers a variety of neural architectures: multilayer perceptron, template matching with winner-take-all (WTA) circuitry, and a new architecture of cascade backpropagation (CBP). Special designs of analog neuron and synapse implemented in VLSI are presented which bear out high speed response both at room and low temperatures with synapse-neuron signal propagation times of ∼100 ns. The CBP learning algorithm is illustrated by solving in simulation the nonlinear 6-bit parity problem. Results show that this algorithm is robust even with synaptic resolutions limited to 5 bits. Therefore, it is particularly suitable for hardware implementation.
Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori (2009)

MicroRNAs (miRNAs) are endogenous non-coding genes that participate in post-transcription regulation by either degrading mRNA or blocking its translation. It is considered to be very important in regulating insect development and metamorphosis. We conducted a large-scale screening for miRNA genes in the silkworm Bombyx mori using sequence-by-synthesis (SBS) deep sequencing of mixed RNAs from egg, larval, pupal, and adult stages. Of 2,227,930 SBS tags, 1,144,485 ranged from 17 to 25 nt, corresponding to 256,604 unique tags. Among these non-redundant tags, 95,184 were matched to the silkworm genome. We identified 3,750 miRNA candidate genes using a computational pipeline combining RNAfold and TripletSVM algorithms. We confirmed 354 miRNA genes using miRNA microarrays and then performed expression profile analysis on these miRNAs for all developmental stages. While 106 miRNAs were expressed in all stages, 248 miRNAs were egg- and pupa-specific, suggesting that insect miRNAs play a significant role in embryogenesis and metamorphosis. We selected eight miRNAs for quantitative RT-PCR analysis; six of these were consistent with our microarray results. In addition, we searched for orthologous miRNA genes in mammals, a nematode, and other insects and found that most silkworm miRNAs are conserved in insects, whereas only a small number of silkworm miRNAs has orthologs in mammals and the nematode. These results suggest that there are many miRNAs unique to insects.
OVERVIEW OF THE COMMON DLR/ONERA PROJECT "ACTIVE TWIST BLADE" (ATB) (2004)

Individual blade control (IBC) as well as higher harmonic control (HHC) for helicopter rotors promises to be a method to increase flight performance and to reduce vibration and noise. For those controls, an additional twist actuation of the blade is needed. Within the DLR/ONERA partnership, a project called “Active Twist Blade” (ATB) was established on a Joint Team in which two concepts for active twist blades are investigated. This paper presents an overview of the project as well as a description of the two concepts including first demonstrators to prove the feasibility of those activation mechanism.
Aerosol Drug Delivery (2007)

This chapter contains sections titled: Introduction Human Respiratory Tract and Aerosol Particle Deposition Therapeutic Indications for Aerosol Delivery Aerosol Drug Delivery Devices Metered Dose Inhalers Dry Powder Inhalers Nebulizers Emerging Technologies Conclusions References
Colorectal Cancer with EML4-ALK Fusion Gene Response to Alectinib: A Case Report and Review of the Literature (2021)

Anti-epithelial growth factor receptor or anti-vascular endothelial growth factor agents combined with chemotherapy were the standard of treatment for metastatic colorectal cancer (CRC). However, increasing evidence of molecularly stratified treatment makes the complexity of treatment. Anaplastic lymphoma kinase (ALK) gene alternation is one of potential target for biomarker-guided therapy for CRC. We present a case of a 56-year-old man who suffered from advanced ascending colon cancer, harboring echinoderm microtubule associated protein-like 4 (EML4)-ALK fusion gene E21; A20 variant, a rare variant in EML4-ALK fusion gene in lung cancer. We also detected this fusion gene from different tissue types including circulating tumor DNA (ctDNA) and ascites fluid. The patient was offered alectinib, an ALK inhibitor, with partial response in lung, liver, and peritoneal metastasis for 8 months. Tumor heterogeneity, especially in gastrointestinal tract cancer, raise our interest in comprehensive genetic profiling in clinical practice. Convenience and reliability of next-generation sequencing, including using ctDNA, help physicians deal with clinical dilemma. ALK-positive CRC is rare. However, advanced CRC with ALK gene alteration responds to ALK inhibitor. It is reasonable to check ALK gene alteration in clinical practice for CRC.
A 10b 200MS/s 0.82mW SAR ADC in 40nm CMOS (2013)

This paper reports a successive-approximation analog-to-digital converter (ADC) which combines the bypass window and direct switching technique to tolerate the incomplete settling error and reduce the control logic delay. A small unit capacitor cell reduces the power consumption and settling time. The 10-bit prototype is fabricated in a 40nm CMOS process. At 200 MS/s and 0.9-V supply, this ADC consumes 0.82 mW and achieves an SNDR of 57.16 dB, resulting in an FOM of 13.9 fJ/Conversion-step.
Multistable switching due to magnetic vortices pinned at artificial pinning sites (2004)

Magnetic vortices form the ground state in micron and submicron ferromagnetic disks. By inserting artificial defects (antidots) into a submicron ferromagnetic disk, magnetic vortices can be pinned controllably thus enabling a different way for magnetic switching. We show that by inserting n antidots into a disk magnetization reversal takes place via n-1 jumps of the vortex core between neighboring antidots. This cannot only be used to establish stable two-state switching for n=2, but also to realize a multilevel remanent state with low switching fields.