gebhart/patrepeval huggingface dataset:
[Evaluation of the simultaneous detection system for Chlamydia trachomatis/Neisseria gonorrhoeae DNA by the isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN)]. (2003)

The isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN) is a new isothermal DNA amplification method composed of exo Bca DNA polymerase, RNaseH and DNA-RNA chimeric primers. We developed the simultaneous detection system for Chlamydia trachomatis/Neisseria gonorrhoeae DNA, combined with luminescence detection by a probe hybridization. In the performance tests, this system was able to detect 10 to 100 copies of C. trachomatis/N. gonorrhoeae DNA for only 3.5 hours, and was highly specific to C. trachomatis/N. gonorrhoeae without any cross-reaction to C. pneumoniae, N. lactamica, N. sicca or N. meningitidis. When we tested 60 clinical samples of urine and cervical swabs, the interpretive results were completely consistent with those obtained by Roche PCR system. Of 13 positive samples by the ICAN and PCR systems for C. trachomatis, four were negative by EIA method(IDEIA Chlamydia). These results indicate that the ICAN system is an efficient and sensitive system to simultaneously detect C. trachomatis/N. gonorrhoeae DNA.
Human and Computer Control of Undersea Teleoperators (1978)

The potential of supervisory controlled teleoperators for accomplishment of manipulation and sensory tasks in deep ocean environments is discussed. Teleoperators and supervisory control are defined, the current problems of human divers are reviewed, and some assertions are made about why supervisory control has potential use to replace and extend human diver capabilities. The relative roles of man and computer and the variables involved in man-computer interaction are next discussed. Finally, a detailed description of a supervisory controlled teleoperator system, SUPERMAN, is presented.
Reduction of Aryl Thiocyanates with SmI<sub>2</sub> and Pd-Catalyzed Coupling with Aryl Halides as a Route to Mixed Aryl Sulfides (1996)

A series of aryl iodides, with a range of substituents, has been successfully coupled using 10 mol % Pd catalyst with samarium thiolates, derived from the corresponding aryl thiocyanates upon reductive cleavage with SmI(2). Reactions proceed in THF at 65 degrees C in yields ranging from good to excellent and are compatible with both electron-donating and electron-withdrawing substituents, except NO(2). The reactions may also be conducted with aryl bromides although with somewhat lower yields.
Micro-drilling of silicon wafer by industrial CO2 laser (2015)

Laser micromachining is currently used in the MEMS production to replace the traditional etching process which consumes longer time to complete. The objective of this study is to investigate the drilling capability of industrial CO2 laser in processing of silicon wafer. In this work, the holes were drilled on P-type silicon wafer with thickness of 525 μm. Geometrical characteristic of holes produce, which is diameter entrance that depends on laser parameter were investigated and analyzed. Analysis of Variance (ANOVA) was used to analyze the result and generated an appropriate model for the laser drilling processing. The laser parameters involved were laser power, pulse frequency and duty cycle. The experimental results showed the entrance diameter of drilling holes was increase when the laser power and duty cycle increased. The entrance diameter of drilling hole decreases when the pulse frequency increases.
Synthesis and structure-activity relationship of spiro[isochromanpiperidine] analogs for inhibition of histamine release. 1 (1981)

Two types of 1'-alkylspiro[isochroman-3,4-piperidines] and 1'-alkylspiro[isochroman-4,4'-piperidines] were prepared and examined for their biological activity. Several of the compounds inhibited the compound 48/80 induced histamine release from isolated rat peritoneal mast cells. The structural requirements for this activity in the present series are discussed.
A New Concept in Fracture Immobilization (1993)

Sixteen dogs and 14 anatomic tibiae were studied to determine the effect of a pressurized brace on a canine tibial fracture model. Bilateral tibial fractures were treated with an external fixator for 48 days. At 48 days, the pressurized brace was applied to one tibia, and a conventional cast was applied to the opposite tibia. The dogs were allowed unrestricted weight bearing until 88 days. Postmortem biomechanical studies indicated that tibiae were stronger on the side treated by the pressurized brace. This was reflected in torque values, energy, and degrees of rotation. The histomorphometry of the periosteal bone of the fracture sites disclosed a more dense periosteal callus on the side treated with a pressurized brace. In vitro mechanical studies in cadaveric tibias at 30 degrees rotation indicated that the pressurized brace provided significantly more stability.
Flt-1 Signaling in Macrophages Promotes Glioma Growth <i>In vivo</i> (2008)

Abstract Several lines of evidence indicate that Flt-1, a fms-like tyrosine kinase receptor, which binds to vascular endothelial growth factor (VEGF)-A, VEGF-B, and PlGF, is a positive regulator of angiogenesis in the context of tumor growth and metastasis. However, the molecular basis of its action is still not clear. Besides endothelial cells, Flt-1 is also expressed by other different cell types, including myeloid hematopoeitic cells (monocytes and macrophages). To examine the functions of Flt-1 expressed by bone marrow–derived myeloid cells in supporting tumor growth and angiogenesis, Flt-1 tyrosine kinase–deficient (Flt-1 TK−/−) bone marrow cells were transplanted into lethally irradiated syngeneic recipients. After hematopoietic reconstitution, we orthotopically implanted syngeneic wild-type glioma cells or glioma cells overexpressing either VEGF164 or PlGF-2. Loss of Flt-1 signaling in bone marrow–derived myeloid cells led to a significant decrease in tumor volume and vascularization in gliomas. VEGF but not PlGF overexpressed by glioma cells restored the tumor growth rate in Flt-1 TK−/− bone marrow chimera. VEGF and PlGF overexpression by tumor cells induced an accumulation of bone marrow–derived myeloid cells into tumor tissue. This infiltration was decreased in tumors grown in Flt-1 TK−/− bone marrow chimeras. When investigating chemokines and growth factors involved in myeloid cell recruitment, we determined elevated SDF-1/CXCL12 levels in VEGF- and PlGF-overexpressing tumors. Collectively, these results suggest that Flt-1 signaling in myeloid cells is essential to amplify the angiogenic response and to promote glioma growth. [Cancer Res 2008;68(18):7342–51]
Mitigation of Random Query String DoS via Gossip (2011)

This paper presents a mitigation scheme to cope with the random query string Denial of Service (DoS) attack, which is based on a vulnerability of current Content Delivery Networks (CDNs). The attack exploits the fact that edge servers composing a CDN, receiving an HTTP request for a resource with an appended random query string never saw before, ask the origin server for a (novel) copy of the resource. Such characteristics can be employed to take an attack against the origin server by exploiting edge servers. Our strategy adopts a simple gossip protocol executed by edge servers to detect the attack. Based on such a detection, countermeasures can be taken to protect the origin server and the CDN against the attack. We provide simulation results that show the viability of our approach.
Core-substituted naphthalenediimides (2010)

This feature article reviews research of core-substituted naphthalenediimides (cNDIs) in a comprehensive yet easily readable manner. Their synthesis, electrochemistry and spectroscopy are covered first with emphasis on the ability of cNDIs with electron donating substituents to absorb and fluoresce in all colors without global structural changes and cNDIs with electron withdrawing substituents to reach unprecedented extents of pi-acidity. The section on supramolecular chemistry covers face-to-face pi-stacks and peripheral hydrogen bonds, that on molecular recognition moves from pH and fluoride sensors to the binding to telomeric DNA in vivo and intercalation into pi-stacks and sticky tweezers. cNDIs can recognize and transport anions by functional anion-pi interactions. The section on electron transport describes cNDIs as air-stable n-semiconductors with high charge mobility and use as OFETs. Photoinduced electron transport by rainbow cNDIs has been used for the creation of artificial photosystems in solution, in bilayer membranes and on solid substrates. Examples include multicolor light harvesting architectures, organic solar cells, photosystems that can open up into ion channels, and supramolecular n/p-heterojunctions with antiparallel redox gradients. The review is highly interdisciplinary but should appeal most to organic, biosupramolecular and physical chemists.
Neutral atoms are entangled in hyperfine states via Rydberg blockade (2010)

An interaction between highly excited atoms can be used to engineer a superposition of low-energy quantum states, as two research groups now demonstrate.
Leptomeningeal Metastasis (2005)

Leptomeningeal metastasis is a common complication of cancer. Often the diagnosis can be difficult, but early diagnosis and aggressive treatment can prevent irreversible neurologic deficits. Diagnosis is usually established by the demonstration of malignant cells in the cerebrospinal fluid (CSF) or by the presence of enhancing tumor nodules on cranial or spinal MRI. Treatment may require focal radiotherapy to symptomatic sites accompanied by chemotherapy. Intra-CSF chemotherapy requires normal CSF flow dynamics and is typically limited to the use of methotrexate, cytarabine or thiotepa. Intrathecal chemotherapy is rarely efficacious, except for hematopoietic neoplasms and, to a lesser extent, breast cancer. Increasingly, systemic chemotherapy is recognized as efficacious in the treatment of leptomeningeal metastasis in part because it has the ability to penetrate into bulky disease seen on neuroimaging. The optimum choice of therapy depends upon a thorough assessment of the neurologic extent of disease, which should include complete neuraxis imaging. Patients with extensive bulky disease may be best treated with systemic chemotherapy, whereas those with a positive CSF cytology but negative imaging may be treated with intrathecal chemotherapy and spared the systemic toxicity of intravenous drug. Despite vigorous therapy, many patients do poorly and the median survival is only about four months. Nevertheless, some patients, particularly those with leukemia, lymphoma, and breast cancer, respond and a substantial minority will be alive one to two years after diagnosis.
Supercritical CO2 mixture behavior for advanced power cycles and applications. (2011)

Abstract not provided.
Aberration-free superresolution imaging via binary speckle pattern encoding and processing (2007)

We present an approach that provides superresolution beyond the classical limit as well as image restoration in the presence of aberrations; in particular, the ability to obtain superresolution while extending the depth of field (DOF) simultaneously is tested experimentally. It is based on an approach, recently proposed, shown to increase the resolution significantly for in-focus images by speckle encoding and decoding. In our approach, an object multiplied by a fine binary speckle pattern may be located anywhere along an extended DOF region. Since the exact magnification is not known in the presence of defocus aberration, the acquired low-resolution image is electronically processed via a parallel-branch decoding scheme, where in each branch the image is multiplied by the same high-resolution synchronized time-varying binary speckle but with different magnification. Finally, a hard-decision algorithm chooses the branch that provides the highest-resolution output image, thus achieving insensitivity to aberrations as well as DOF variations. Simulation as well as experimental results are presented, exhibiting significant resolution improvement factors.
Effects of discontinuities (vias) on high speed interconnects (2002)

Vias and bends are commonly encountered as nonuniformities along traces of interconnect on high performance multichip modules. The extent of degradation of signal propagation characteristics due to the presence of discontinuities has been investigated by developing and using a simulator based on the transmission (ABCD) matrix parameters, which facilitates concatenation of many transmission line systems. The approach models the reactive energy stored in a discontinuity as a lumped tee-network using three dimensional parameter extractors. A case study on the thick film geometry of the IBM ES9000 module investigates the effects of vias on propagation delay time, signal distortion, characteristic impedance and additional noise generated due to reflections at the termination and at the source for different input rise times.
Testosterone Reduces Conscious Detection of Signals Serving Social Correction (2007)

Elevated levels of testosterone have repeatedly been associated with antisocial behavior, but the psychobiological mechanisms underlying this effect are unknown. However, testosterone is evidently capable of altering the processing of facial threat, and facial signals of fear and anger serve sociality through their higher-level empathy-provoking and socially corrective properties. We investigated the hypothesis that testosterone predisposes people to antisocial behavior by reducing conscious recognition of facial threat. In a within-subjects design, testosterone (0.5 mg) or placebo was administered to 16 female volunteers. Afterward, a task with morphed stimuli indexed their sensitivity for consciously recognizing the facial expressions of threat (disgust, fear, and anger) and nonthreat (surprise, sadness, and happiness). Testosterone induced a significant reduction in the conscious recognition of facial threat overall. Separate analyses for the three categories of threat faces indicated that this effect was reliable for angry facial expressions exclusively. This testosterone-induced impairment in the conscious detection of the socially corrective facial signal of anger may predispose individuals to antisocial behavior.
Visiones de la conquista y la colonización de las Américas (2015)

Este libro reune las aportaciones de un grupo de especialistas provenientes de campos que van de la Historia a la Historia de las ideas politicas y la Filosofia, para analizar en clave comparativa la conquista y colonizacion de America. Las comparaciones van de los siglos XVI al XIX; abarcan el norte y el sur; incluyen la mirada de misioneros y viajeros y la de teoricos de gabinete que nunca pisaron aquellas tierras; recogen el pensamiento de autoctonos y el de extranos a aquellos mundos; prestan atencion a textos filosoficos e historicos, documentos diplomaticos y cartas privadas; y, por no agotar la enumeracion, se extienden tambien a formas expresivas tan diversas como la escritura, las imagenes y el cine. A traves de esta diversidad de medios hemos querido continuar la tarea iniciada en otro libro anterior (F. Castilla Urbano, ed., Discursos legitimadores de la conquista y la colonizacion de America. Alcala de Henares. Universidad de Alcala. Servicio de Publicaciones, 2014), y seguir prestando atencion a los procesos de conquista y colonizacion del Nuevo Mundo a traves de los discursos filosoficos, ideologicos y politicos por medio de los cuales se legitimaron.
High Performance Embedded Computing Software Initiative (HPEC-SI) Program Facilitation of VSIPL++ Standardization (2008)

Abstract : The Vector Signal and Image Processing Library (VSIPL) is an industry standard Application Programming Interface for embedded signal processing tasks. The High Performance Embedded Computing Software Initiative (HPEC-SI) program is a collaborative program to establish extensions to the VSIPL specification to support Object Oriented elements of the C++ programming language, and encapsulated support for data parallel processing. The program goals include the simultaneous threefold improvement in software portability, threefold improvement in developer productivity, and fifty percent improvement in software performance compared to standard practices. This report describes the efforts of the Georgia Tech Research Institute in support of the HPEC-SI program during the period from June 2006 through December 2007. These efforts included development of organizational strategies, participation in the HPEC-SI Applied Research and Development Working Groups, dissemination of program results to outside organizations via internet tools, and maintenance of a parallel computing software testbed for program participants, and development of an automated process for the configuration of certain types of computing nodes.
An Ecological and Economic Assessment of the Nontimber Forest Product Gaharu Wood in Gunung Palung National Park, West Kalimantan, Indonesia (2001)

Abstract: Ecological and economic data are essential to the identification of tropical nontimber forest products with the potential for sustainable and profitable extraction in a managed system. We studied the demographic effect and economic returns of harvesting aromatic gaharu wood from fungus‐infected trees of Aquilaria malaccensis Lam. at Gunung Palung National Park, Indonesia, to evaluate the management potential of gaharu wood. Aquilaria malaccensis trees openface> 20 cm in diameter occurred at low preharvest densities (0.16–0.32 ha) but were distributed across five of six forest types surveyed. During a recent harvest, 75% of trees were felled, with harvest intensities ranging from 50% to 100% among forest types. Overall, 50% of trees contained gaharu wood, but trees at higher elevations contained gaharu wood more frequently ( 73%) than trees at lower elevation (27%). The mean density of regeneration ( juveniles> 15 cm in height) near adult trees (3–7 m away) was 0.2/m 2 , 200 times greater than at random in the forest (10/ha), but long‐term data on growth and survivorship are needed to determine whether regeneration is sufficient for population recovery. Gaharu wood extraction from Gunung Palung was very profitable for collectors, generating an estimated gross financial return per day of US $8.80, triple the mean village wage. Yet, the estimated sustainable harvest of gaharu wood at natural tree densities generates a mean net present value of only $10.83/ha, much lower than that of commercial timber harvesting, the dominant forest use in Kalimantan. Returns per unit area could be improved substantially, however, by implementing known silvicultural methods to increase tree densities, increase the proportion of trees that produce gaharu wood, and shorten the time interval between successive harvests. The economic potential of gaharu wood is unusual among nontimber forest products and justifies experimental trials to develop small‐scale cultivation methods.
Provide guidance to adjuncts teaching online when they need it (2014)

Providing support to faculty members who teach online can be a challenge. That's especially true at an institution like Ashford University, where most of them are adjuncts who teach nights and weekends and work during the day at other jobs. But because so many adult learners opt for online classes because of the flexibility and convenience they offer, it's important that adjunct teaching in your distance programs have the resources and support they need to be good teachers.
Atrial fibrillation in heart failure: the chicken or the egg? (2008)

Atrial fibrillation (AF) and heart failure (HF) are the emerging epidemics of cardiovascular disease in the new millennium. Both are responsible for considerable morbidity and mortality and health budget expenditure. The advent of catheter ablation for patients with AF has provided important new insights into the relative contribution of AF to left ventricular dysfunction. The aim of this review is to discuss the complex interplay in the pathophysiology of AF and HF to improve our understanding of the basis for current treatment strategies and guide future research direction.
Performance of Ge-on-Si p-i-n Photodetectors for Standard Receiver Modules (2006)

Ge on Si p-i-n photodetectors with areas which are compatible with commercially available receivers have been fabricated and tested. A dark current density of 6 mA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at -1-V bias has been measured at room temperature; when heated to 85 degC, the measured dark current increases by a factor of nine. A responsivity of 0.59 A/W at 850 nm has been measured from these Ge detectors, which matches or exceeds commercially available GaAs devices. We have measured bandwidths approaching 9 GHz at -2-V bias from 50-mum diameter Ge detectors, and have observed eye diagrams comparable to those obtained from GaAs-based receivers at 4.25 Gb/s
A System Design for a Hybrid Network Data Communications Terminal Using Asymmetric TCP/IP to Support Internet Applications (1994)

Access to the Internet is either too slow (e.g. dial-up SLIP) or too expensive (e.g. switched 56 kbps, frame relay) for the home user or small enterprise. The Center for Satellite and Hybrid Communication Networks and Hughes Network Systems have collaborated using system integration principles to develop a prototype of a low-cost hybrid (dial-up and satellite) network terminal which can deliver data from the Internet to the user at rates up to 160 kbps. An asymmetric TCP/IP connection is used breaking the network link into two physical channels: a terrestrial dial-up link for carrying data from the terminal into the Internet and a receiver-only satellite link carrying IP packets from the Internet to the user. With a goal of supporting bandwidth hungry Internet applications such as Mosaic Gopher, and FTP, this system has been designed to support any Intel 80386/486 PC, any commercial TCP/IP package, any unmodified host on the Internet, and any of the routers, etc. within the Internet. The design exploits the following three observations: 1) satellites are able to offer high bandwidth connections to a large geographical area, 2) a receiver-only VSAT is cheap to manufacture and easier to install than one which can also transmit, and 3) most computer users, especially those in a home environment, will want to consume much more data than they generate. IP encapsulation, or tunneling, is used to manipulate the TCP/IP protocols to route packets asymmetrically.