gebhart/patrepeval huggingface dataset:
ATP Induces a Rapid and Pronounced Increase in 2-Arachidonoylglycerol Production by Astrocytes, a Response Limited by Monoacylglycerol Lipase (2004)

The cytoplasm of neural cells contain millimolar amounts of ATP, which flood the extracellular space after injury, activating purinergic receptors expressed by glial cells and increasing gliotransmitter production. These gliotransmitters, which are thought to orchestrate neuroinflammation, remain widely uncharacterized. Recently, we showed that microglial cells produce 2-arachidonoylglycerol (2-AG), an endocannabinoid known to prevent the propagation of harmful neuroinflammation, and that ATP increases this production by threefold at 2.5 min (Witting et al., 2004). Here we show that ATP increases 2-AG production from mouse astrocytes in culture, a response that is more rapid (i.e., significant within 10 sec) and pronounced (i.e., 60-fold increase at 2.5 min) than any stimulus-induced increase in endocannabinoid production reported thus far. Increased 2-AG production from astrocytes requires millimolar amounts of ATP, activation of purinergic P2X7 receptors, sustained rise in intracellular calcium, and diacylglycerol lipase activity. Furthermore, we show that astrocytes express monoacylglycerol lipase (MGL), the main hydrolyzing enzyme of 2-AG, the pharmacological inhibition of which potentiates the ATP-induced 2-AG production (up to 113-fold of basal 2-AG production at 2.5 min). Our results show that ATP greatly increases, and MGL limits, 2-AG production from astrocytes. We propose that 2-AG may function as a gliotransmitter, with MGL inhibitors potentiating this production and possibly restraining the propagation of harmful neuroinflammation.
Microseismic imaging of hydrofractures with the aid of conical waves (1993)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1993Microseismic imaging of hydrofractures with the aid of conical wavesAuthors: David C. IldertonTadeusz W. PatzekJames W. RectorHarold J. VinegarDavid C. IldertonUniversity of California, Berkeley, Tadeusz W. PatzekUniversity of California, Berkeley, James W. RectorUniversity of California, Berkeley, and Harold J. VinegarShell Development Co.https://doi.org/10.1190/1.1822457 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1822457FiguresReferencesRelatedDetailsCited ByPassive Imaging of Hydrofractures in the South Belridge Diatomite1 March 1996 | SPE Formation Evaluation, Vol. 11, No. 01 SEG Technical Program Expanded Abstracts 1993ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1993 Pages: 1396 publication data© 1993 Copyright © 1993 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION David C. Ilderton, Tadeusz W. Patzek, James W. Rector, and Harold J. Vinegar, (1993), "Microseismic imaging of hydrofractures with the aid of conical waves," SEG Technical Program Expanded Abstracts : 267-270. https://doi.org/10.1190/1.1822457 Plain-Language Summary PDF DownloadLoading ...
Advantages of Sheep Infrapatellar Fat Pad Adipose Tissue Derived Stem Cells in Tissue Engineering (2016)

Our results suggest that ASCs surface markers can be characterized by anti-human antibodies in sheep. As stem cells, they can be used in tissue engineering.
Supramolecular structures of poly(p-phenylenes) with oxyethylene side chains and their mixtures with lithium salts (1998)

A series of poly(p-phenylenes) with linear and branched oxyethylene side chains was synthesized. Microphase separation in the solid state causes polymers with linear side chains to form supramolecular structures, which consist of main chain layers separated by an amorphous side chain matrix. If mixed with lithium salts such as lithium triflate (LiOTf) or lithium bis(trifluoromethanesulfone)imide (LiNTf), the polymers form solid solutions. The experimental data suggest that the layered structures undergo a one-dimensional swelling in the direction perpendicular to the main chain layers when blended with LiOTf and that this salt is only incorporated into the side chain matrix. The observed melting point depression in polymer-LiNTf mixtures is explained by the assumption that the salt species are incorporated both into the side chain and the main chain microphase.
SEXOLOGÍA: GÉNERO, IDENTIDAD Y DERIVAS CULTURALES (1999)

La sexología nace en el mismo desplazamiento con que se impone la antropología: una nueva mirada hacia la alteridad, En ese movimiento, el concepto de «género» constituye un esfuerzo por superar la lateralidad histórica de la mujer entrelazando su «naturalidad» con una nueva disponibilidad cultural. Hoy, sin embargo, en la misma evolución de la sexología -y de la antropología (filosófica)- parece imponerse una desobediencia representativa al género: la subjetivación del placer.
Effect of birefringence in a bulk semiconductor optical amplifier on four-wave mixing (1998)

We present experimental results on birefringence effects in an InGaAsP bulk semiconductor optical amplifier (SOA). Although the gain of the device is polarization insensitive, we observed a strong variation of the four-wave mixing (FWM) efficiency if the parallel input polarization of pump and signal wave was changed with respect to the device structure. This variation, which is attributed to birefringence in the SOA, can be as high as 10 dB for frequency detunings of about 6 THz. Thus, it might strongly affect the various applications of FWM for optical signal processing and parameter extraction. In addition, we performed polarization resolved measurements of the amplified spontaneous emission demonstrating different group velocity indices for TE and TM polarized light.
The Formation of Manganese and Cobalt Ferrites by the Air Oxidation of Aqueous Suspensions and Their Properties (1978)

Abstract Manganese and cobalt ferrites were prepared by the air oxidation of aqueous suspension of Fe(OH)2 and either Mn(OH)2 or Co(OH)2 at 50–80 °C. In alkaline suspensions, all the metal ions are transformed into spinel ferrites, MxFe3−xO4 (M=Mn or Co), by a suitable combination of the oxidation temperature and the concentration of the excess NaOH. Both manganese and cobalt ferrites consist of ferromagnetic particles (ferrite(A)) when x is smaller than 1.3, nonferromagnetic particles (ferrite(B)) when x is larger than 2, and mixtures of the two in the intervening range. The contents of Mn or Co, both in a solid solution of hydroxides, Mx⁄3Fe1−x⁄3(OH)2, and in ferrite, increase with the progress of the formation of the ferrite(A) caused by oxidation. The formation of the ferrite(B) begins when x in the solid solution reaches 2. Each particle in the ferrite(A) is less homogeneous in comparison with that in the ferrite prepared by a solid-state reaction, although with the same composition. The difference in the homogeneity causes the essential difference in magnetic properties.
Comparison of Two Commercial Microimmunofluorescence Kits and an Enzyme Immunoassay Kit for Detection of Serum Immunoglobulin G Antibodies to <i>Chlamydia pneumoniae</i> (2001)

We compared the MRL and the Labsystems Chlamydia pneumoniae microimmunofluorescence (MIF) immunoglobulin G (IgG) kits and the Labsystems enzyme immunoassay (EIA) kit in a blinded study of 83 serum samples in which we evaluated titers, cross-reactivity to other species, and reproducibility. There was no statistically significant difference between the MRL and the Labsystems MIF kits in the endpoint titers of IgG antibody to C. pneumoniae. The correlation between the results obtained with these two MIF kits was excellent (r = 0.95; P = 0.001). The cross-reactivity of the C. pneumoniae-positive sera with C. trachomatis- and C. psittaci-positive sera was assessed for each MIF kit. For C. pneumoniae-positive sera with titers of > or =32, the Labsystems MIF kit exhibited more cross-reactivity to C. psittaci than the MRL kit did. The values obtained with the Labsystems EIA kit represented single dilutions of serum specimens expressed as enzymeimmuno units on a continuous scale. The results obtained with the Labsystems EIA kit correlated moderately well with those obtained with each MIF kit when they were compared for their abilities to detect IgG antibodies to C. pneumoniae (for the MRL MIF kit, r = 0.79 [P = 0.001]; for the Labsystems MIF kit, r = 0.78 [P = 0.001]). The results obtained with the commercial MRL and Labsystems MIF kits and the Labsystems EIA kit tested were reproducible; and the kits were standardized, had quality control reagents, and are suitable for detection of C. pneumoniae antibodies in serum and for use in interlaboratory studies. Validation of the use of these kits for clinical diagnosis still needs further evaluation.
The Preparation of VO3+ and VO2+ Complexes Using Hydrolytically Stable, Asymmetric Ligands Derived from Schiff Base Precursors (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of VO3+ and VO2+ Complexes Using Hydrolytically Stable, Asymmetric Ligands Derived from Schiff Base PrecursorsGerard J. Colpas, Brent J. Hamstra, Jeff W. Kampf, and Vincent L. PecoraroCite this: Inorg. Chem. 1994, 33, 21, 4669–4675Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/ic00099a017https://doi.org/10.1021/ic00099a017research-articleACS PublicationsRequest reuse permissionsArticle Views578Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Security issues for implementation of e-medical records (2001)

article Security issues for implementation of e-medical records Author: Terry Huston University of Victoria, British Columbia, Canada University of Victoria, British Columbia, CanadaView Profile Authors Info & Claims Communications of the ACMVolume 44Issue 901 September 2001pp 89–94https://doi.org/10.1145/383694.383712Published:01 September 2001Publication History 29citation4,860DownloadsMetricsTotal Citations29Total Downloads4,860Last 12 Months55Last 6 weeks15 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Purification and characterization of succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase from Escherichia coli. (1984)

Tetrahydrodipicolinate succinylase, an enzyme involved in the diaminopimelate-lysine pathway, was purified 1900-fold from crude extracts of Escherichia coli. The enzyme catalyzes the formation of CoA and N-succinyl-2-amino-6-keto-L-pimelate from succinyl-CoA and tetrahydrodipicolinate. The purified enzyme was shown to be homogeneous by polyacrylamide gel electrophoresis. The Stokes radius of the enzyme was determined from its elution volume on a Sephacryl S300 column and its sedimentation constant from sucrose density gradient centrifugation. These were 35 A and 4.7 (S20,w), respectively. The enzyme consists of two subunits each with a mass of 31,000 daltons, as determined using sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Tetrahydrodipicolinate succinylase was shown to be a sulfhydryl enzyme. It has a pH optimum of 8.2. The equilibrium lies predominantly in favor of product formation but the reverse reaction can be demonstrated in vitro.
On the Complexity of Some Common Geometric Location Problems (1984)

Given n demand points in the plane, the p-center problem is to find p supply points (anywhere in the plane) so as to minimize the maximum distance from a demand point to its respective nearest supply point. The p-median problem is to minimize the sum of distances from demand points to their respective nearest supply points. We prove that the p-center and the p-median problems relative to both the Euclidean and the rectilinear metrics are NP-hard. In fact, we prove that it is NP-hard even to approximate the p-center problems sufficiently closely. The reductions are from 3-satisfiability.
Microcontroller based distributed and networked control system for public cluster (2009)

We present the architecture and application of the distributed control in public cluster, a parallel machine which is open for public access. Following the nature of public cluster, the integrated distributed control system is fully accessible through network using a user-friendly web interface. The system is intended mainly to control the power of each node in a block of parallel computers provided to certain users. This is especially important to extend the life-time of related hardwares, and to reduce the whole running and maintainance costs. The system consists of two parts : the master- and node-controllers, and both are connected each other through RS-485 interface. Each node-controller is assigned with a unique address to distinguish each of them. We also discuss briefly the implementation of the system at the LIPI Public Cluster.
Multiparametric or practical quantitative liver MRI: towards millisecond, fat fraction, kilopascal and function era (2016)

New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620 ms for 1.5 T and 700-850 ms for 3 T), T2, T2* (>20 ms), T1rho (40-50 ms) mapping, proton density fat fraction (PDFF) (≤5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%). T1 mapping can be important for the assessment of fibrosis, amyloidosis and copper overload. T1rho mapping is promising for the assessment of liver collagen deposition. PDFF can allow objective treatment assessment in NAFLD and NASH patients. T2 and T2* are used for iron overload determination. MR fingerprinting may enable single slice acquisition and easy implementation of multiparametric MRI and follow-up of patients. Areas covered: T1, T2, T2*, PDFF and stiffness, diffusion weighted imaging, intravoxel incoherent motion imaging (ADC, D, D* and f values) and function analysis are reviewed. Expert commentary: Multiparametric MRI can enable biopsyless diagnosis and more objective staging of diffuse liver disease, cirrhosis and predisposing diseases. A comprehensive approach is needed to understand and overcome the effects of iron, fat, fibrosis, edema, inflammation and copper on MR relaxometry values in diffuse liver disease.
Enhanced chaotic image encryption algorithm based on Baker's map (2003)

Imaging has gained importance due to the improvements of performances in computer speed, media storage and network bandwidth. Along with this advancement, the fundamental issue of image security has become a major concern and because of this reason, research in image confidentiality has gained popularity amongst security experts. This paper discusses an alternative chaotic image encryption based on Baker's map. This enhanced symmetric-key algorithm can support a variable-size image as opposed to the algorithm which is mainly based on Baker's map that requires only square image for encryption. In addition, the algorithm also includes other functions such as password binding and pixel shifting to further strengthen the security of the cipher image. The algorithm also supports two modes of operation namely EBC and CBC. The number of iterations to be performed can vary depending on the security level required by the user. The paper also includes an example of image encryption. From the analysis done, it shows that the security level is high even though keys that are found to be weak keys for Baker's map algorithm are being used in the algorithm.
Generation of Code for Reading Data from the Declarative File Format Specifications Written in Language FlexT (2018)

The language FlexT (Flexible Types) is intended for specification of binary data formats. The language is declarative and designed to be well understood for human readers. Its main elements are the data type declarations, which look very much like the usual type declarations of the imperative programming languages, but are more flexible. While the primary purpose of the language FlexT development was to make the binary data understandable by displaying them according to the format specifications, recently we have implemented the code generator, which can produce data reading code in some imperative languages from the specifications. By now we have implemented the code generation for the most widely used FlexT data types, but some complex types like that used in specifications of machine instructions' encoding are not supported yet. The current capabilities of the code generator are well characterized by that it have successfully produced a full-featured data reader code for the well-known for the GIS community Shape file format. In the article we first give a review of the features of the modern projects oriented to specification of binary file formats and consider their code generation capabilities. Then we briefly review the main features of the FlexT language. Finally we describe the main approaches that we use for the code generation.
Mucoadhesive hydrogel microparticles based on poly (methacrylic acid-vinyl pyrrolidone)-chitosan for oral drug delivery (2010)

The study was aimed at the evaluation of N-vinyl pyrrolidone (NVP) incorporated polymethacrylic acid-chitosan microparticles for oral drug delivery applications. Poly (methacrylic acid)-chitosan (PMC) and poly(methacrylic acid-vinyl pyrrolidone)-chitosan (PMVC) microparticles were prepared by an ionic-gelation method. Mucoadhesion behaviour of these particles was evaluated by ex-vivo adhesion method using freshly excised rat intestinal tissue. Cytotoxicity and absorption enhancing property of PMC and PMVC particles were evaluated on Caco 2 cell monolayers. Protease enzyme inhibition capability and insulin loading/release properties of these hydrogel particles was evaluated under in vitro experimental conditions. Addition of NVP units enhanced the mucoadhesion behavior of PMC particles on isolated rat intestinal tissue. Both PMC and PMVC particles were found non-toxic on Caco 2 cell monolayers and PMC particles was more effective in improving paracellular transport of fluorescent dextran across Caco 2 cell monolayers as compared to PMVC particles. However, protease inhibition efficacy of PMC particles was not significantly affected with NVP addition. NVP incorporation improved the insulin release properties of PMC microparticles at acidic pH. Hydrophilic modification seems to be an interesting approach in improving mucoadhesion capability of PMC microparticles.
Artificial Lift for Slim Holes (2000)

Abstract Liquid removal from gas wells is needed as reservoir pressure declines resulting in lower gas flow rates. As liquids accumulate in the wellbore, the hydrostatic pressure due to the liquid column exerts a backpressure on the producing sand face resulting in lower production rates. As additional liquids enter the wellbore, the well will cease to flow. By removing these liquids, gas production is maintained. Since various artificial lift techniques are used to produce these liquids, it is important that the lifting method be compatible with the size of the completions. The purpose of the paper is to discuss which options are available to lift liquids from slim-hole gas wells.
Epilepsy's next frontier (2019)

Almost one in every three patients suffers from seizures that are resistant to drugs. Scientists are looking for new ways to help them.
Referral for cancer genetics consultation: a review and compilation of risk assessment criteria (2004)

These criteria should improve ease of referral and promote consistency across centres when evaluating patients for referral to cancer genetics specialists.
Role of the area postrema in vomiting and related functions. (1984)

Before 1949, the vomiting center was said to be located in the dorsal vagal nuclei of the medulla, but it was uncertain whether two centers existed separately for the control of direct and reflex actions of emetic agents. Borison and Wang then used a stereotaxic technique with electrical stimulation to localize the vomiting center in the reticular formation at a measurable distance from the dorsal vagal nuclei. They also formulated the concept of a separate emetic chemoreceptor trigger zone (CTZ) so that the vomiting center itself is not sensitive to emetic agents and serves solely to coordinate the reflex process. The CTZ was soon identified with the area postrema (AP), but the question remains unanswered whether the CTZ constitutes part or all of tht circumventricular organ. Furthermore, different chemosensory functions, as for defecation and certain forms of autonomic expression, may be represented regionally within the AP. Species that are unable to vomit, e.g., rodents, show other postrema-mediated effects as radiation-induced gastric stasis and drug-induced conditioned taste aversion. In sheep, digitalis-induced arrest of rumination is prevented by postremectomy. It is suggested that these behavioral end points in nonvomiting species may serve for biological assay of antinauseant drugs. Finally, a tabular summary is given of known causes of vomiting in which the AP has been implicated.
Advanced 3D RESURF devices for power integrated circuits (2003)

Power integrated circuits will be an area of high growth in IT and consumer products due to several factors, among which the following play the crucial role: regulations for increased efficiency, the need for smart features and high reliability, reduced size and weight, and all at a reduced unit cost. This paper is concerned with recent trends in high voltage devices for high voltage integrated circuits and in particular the application of the RESURF effect to the third dimension for a significant increase in the breakdown capability of lateral devices. New 3D device concepts are presented in comparison with classical LDMOSFETs and LIGBTs.
Dihydroimidazoles in synthesis: C-alkylation of 1-benzyl-2-(α-lithioalkyl)-4,5-dihydroimidazoles and a synthesis of alkanoic acids (1986)

1-Benzyl-2-alkyl-4,5-dihydroimidazoles have been (laterally) metallated and C-alkylated by reaction with alkyl halides and an epoxide; intramolecular C-alkylation has led to a tetrahydro-5H-pyrrolo-[1,2-a]imidazole. Hydrolysis of the 4,5-dihydroimidazoles to produce alkanoic acids completes a homologation sequence.