gebhart/patrepeval huggingface dataset:
IgE-binding components in Pityrosporum orbiculare identified by an immunoblotting technique. (1991)

IgE-binding components in crude extracts of Pityrosporum orbiculare were separated by sodium dodecylsulphate polyacrylamide gel electrophoresis and transferred to Immobilon membrane. The components were detected by P. orbiculare radioallergosorbent (RAST) positive sera (class 2-4) from 37 patients with atopic dermatitis and visualized by enzyme-labelled anti-human IgE antibodies in chromogenic substrate. Numerous IgE-binding compounds were demonstrated in the molecular weight (MW) range of 14-94 kD. Eight of them were characterized to molecular size, frequency of reacting sera and intensity of bands. Six of the defined components were found to be major allergens reacting with more than 50% of the sera. They had MWs 86, 76, 67, 28, 17 and 13 kD. Thirty-six of the 37 patients had elevated total serum IgE. Two other patient categories were studied; 11 patients with lymphatic filariasis (high total serum IgE, greater than 1,300 kU/l) and 15 pityriasis versicolor patients (normal total serum IgE, less than 122 kU/l). The P. orbiculare RAST values for these sera showed good accordance with the reactivity in immunoblotting experiments.
High-Resolution Doppler Imager on the Upper Atmosphere Research Satellite (1994)

The high resolution Doppler imager (HRDI) on the Upper Atmosphere Research Satellite has been providing measurements of the wind field in the stratosphere, mesosphere, and lower thermosphere since November 1991. Examination of various calibration data indicates the instrument has remained remarkably stable since launch. The instrument has a thermal drift of about 30 m/s/ degree(s)C (slightly dependent on wavelength) and a long-term temporal drift that has amounted to about 80 m/s since launch. These effects are removed in the data processing leaving an uncertainty in the instrument stability of approximately 2 m/s. The temperature control of the instrument has improved significantly since launch as a new method was implemented. The initial temperature control held the instrument temperature at about +/- 1 degree(s)C. The improved method, which holds constant the temperature of the optical bench instead of the radiator, keeps the instrument temperature at about 0.2 degree(s)C. The calibrations indicate very little change in the sensitivity of the instrument. The detector response has shown no degradation and the optics have not changed their transmittance.
Crystal Structures and Properties of Pb(Ni <sub>1/3</sub> ,Nb <sub>2/3</sub> )O <sub>3</sub> –Pb(Zr <sub>1/2</sub> ,Ti <sub>1/2</sub> )O <sub>3</sub> Thin Films on Silicon Substrates (2015)

Abstract Pb(Zr,Ti)O 3 (PZT)-based ternary system thin films, x Pb(Ni,Nb)O 3 –(1– x )PZT (50/50) (PNN–PZT), are grown on Pt/TiO 2 /SiO 2 /Si substrates using radio-frequency magnetron sputtering system. The intrinsic PZT (50/50) thin films are also deposited for comparison. XRD data display a perovskite structure in PNN–PZT thin films, which is similar with that of PZT films. On the other hand, the adding of PNN induces a change in the ratio of (200)/(002) peak intensity in the diffraction patterns, and the tetragonality of PNN–PZT thin films decreases with increasing x . The morphotropic phase boundary (MPB) of PNN–PZT thin film system is confirmed near the composition of 0.05PNN–0.95PZT. PNN–PZT thin films exhibit excellent piezoelectricity and ferroelectricity which are distinctly better than those of PZT thin films. In particular, very high remanent polarization, P r =99 μC/cm 2 , small coercive field of 55 kV/cm, large relative dielectric constants, ε r =2,030 and distinct piezoelectric response are observed from sample 0.05PNN–0.95PZT.
Silicon Oxide (SiO<i><sub>x</sub></i>): A Promising Material for Resistance Switching? (2018)

Interest in resistance switching is currently growing apace. The promise of novel high-density, low-power, high-speed nonvolatile memory devices is appealing enough, but beyond that there are exciting future possibilities for applications in hardware acceleration for machine learning and artificial intelligence, and for neuromorphic computing. A very wide range of material systems exhibit resistance switching, a number of which-primarily transition metal oxides-are currently being investigated as complementary metal-oxide-semiconductor (CMOS)-compatible technologies. Here, the case is made for silicon oxide, perhaps the most CMOS-compatible dielectric, yet one that has had comparatively little attention as a resistance-switching material. Herein, a taxonomy of switching mechanisms in silicon oxide is presented, and the current state of the art in modeling, understanding fundamental switching mechanisms, and exciting device applications is summarized. In conclusion, silicon oxide is an excellent choice for resistance-switching technologies, offering a number of compelling advantages over competing material systems.
[Photochemistry study on novel water soluble thioxanthone photoinitiators]. (2000)

The photochemistry of nine water soluble thioxanthone photoinitiators was examined by UV absorption, fluorescence, phosphorescence and ESR techniques. Maximal absorption, extinction coefficients, fluorescence and phosphorescence quantum yields, ESR intensity were determined. The solvent effects on absorption and fluorescence as well as the relationship between structure and photochemical activities were discussed.
A Vacuum Type Air-Driven Centrifuge for Biophysical Research (1938)

An improved vacuum type self-balancing centrifuge which is driven by air is described. It is especially suited for spinning rotors larger than 2 inches in diameter at very constant temperatures. Either the ``quantity'' or ``analytical'' type of rotor may be used with the same driving mechanism.
Response of Canola (Brassica napus L.) to Biofertilizers under Egyptian conditions in newly reclaimed soil (2010)

The study was conducted in the farm of Faculty of Agriculture, Demo, Fayoum, Egypt. The soil was of loamy- sand type. During 2006 /2007 and 2007 /2008 season, using a split plot arrangement in randomized complete block design with three replicates, the work was done to determine the effect of adding biofertilizers ( Azotobacter + Azospirillum, free nitrogen fixers and Trichoderma a phosphate solubilizing fungi) in combinations with mineral N fertilizer with either recommended dose (N 1) or half of this dose (N 2) on yield quantity and quality of two canola lines (L 6 and H 2). The results revealed that the two canola lines were significantly different in plant height, number of branches, number of pods and seed yield /plant. L 6 surpassed H 2 line for previous traits, in addition to insignificantly higher values of the other traits; T 10 , T 11 and T 12 showed superiority and high productivity with saving half of the mineral N recommended dose. For interaction; H 2T10 , was the best in all traits except for plant height, protein and oil percentages. H2T4, L 6T6 and L 6T8, for all traits except for seed index and oil percentage. The highest productivity recoded by H2T10 (N 2+Trichoderma +Azotobacter ), H2T11 (N 2 + Azotobacter + Azospirllum ) and L 6T8 (N 2+ Azotobacter ) which outyielded their corresponding control by 39.3, 31.8 and 23.0% a result of using only 50% of the recommended dose of N-fertilizer (N 2). The latter combination was also superior in protein content (26.5%). These three combinations could be recommended as alternative method for canola fertilization, where they had economic and safely advantages.
Correlation of extended spectrum beta lactamases production with cephalosporin resistance in gram negative bacilli. (2004)

Beta lactamase production is an important mechanism of developing resistance to beta lactam group of antibiotics. Cephlosporins with extended spectrum of activity and stability were introduced to overcome this resistance, but soon production of extended spectrum beta lactamases (ESBLs), which are inducible in nature was reported. In this study Klebsiella aerogenes--166, Escherichia coli--120, Citrobacter spps--116, Pseudomonas spps--50, Proteus spps--32 and S. typhi--16, strains were subjected to sensitivity testing against various generations of cephalosporins by disc diffusion method and for the production of ESBLs using disc approximation method. Klebsiella aerogenes, Escherichia coli, Citrobacter spps and Pseudomonas spps showed statistically significant difference in the resistance pattern to all three generations of cephalosporins and ESBLs production.
Probe-pin device for optical neurotransmitter sensing in the brain (2015)

Development of an optical neurotransmitter sensing device using nano-plasmonic probes and a micro-spectrometer for real time monitoring of neural signals in the brain is underway. Clinical application of this device technology is to provide autonomous closed-loop feedback control to a deep brain stimulation (DBS) system and enhance the accuracy and efficacy of DBS treatment. By far, we have developed an implantable probe-pin device based on localized field enhancement of surface plasmonic resonance on a nanostructured sensing domain which can amplify neurochemical signals from evoked neural activity in the brain. In this paper, we will introduce the details of design and sensing performance of a proto-typed microspectrometer and nanostructured probing devices for real time measurement of neurotransmitter concentrations.
S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures (2011)

Sphingosine-1-phosphate receptors (S1PRs) are drug targets for the compound FTY720, which is the first oral therapy developed for treatment of relapsing-remitting multiple sclerosis. S1PRs play a variety of functional roles in the differentiation, proliferation, survival and/or migration of neurons and glia. In this study, rat organotypic cerebellar slice cultures were used to assess whether S1PRs play a role in demyelination induced by lysolecithin (LPC). The data demonstrated that FTY720 and SEW2871 (a S1P1R-specific agonist) inhibited LPC-induced demyelination as assessed by myelin basic protein (MBP) immunofluorescence. Treatment with both drugs for 48 h also induced an increase in S1P1R expression in astrocytes. Moreover, FTY720 and SEW2871 inhibited the release of several chemokines in conditions of LPC-induced demyelination, including LIX (CXCL5), MIP-1alpha, and MIP-3alpha. Taken together, the data suggest that activation of S1P1Rs prevents LPC-induced demyelination via a mechanism involving a reduction of chemotactic chemokine release. The study supports the concept that FTY720 attenuates demyelination by not only preventing S1PR-mediated T cell migration into the CNS but also by limiting cytokine communication between cells of the immune system and the CNS.
Development and Application of the Finite Element Analysis Program of the Stress-Based Forming Limit Criterion for Sheet Metal Forming (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Big data classification (2014)

This paper focuses on the specific problem of Big Data classification of network intrusion traffic. It discusses the system challenges presented by the Big Data problems associated with network intrusion prediction. The prediction of a possible intrusion attack in a network requires continuous collection of traffic data and learning of their characteristics on the fly. The continuous collection of traffic data by the network leads to Big Data problems that are caused by the volume, variety and velocity properties of Big Data. The learning of the network characteristics require machine learning techniques that capture global knowledge of the traffic patterns. The Big Data properties will lead to significant system challenges to implement machine learning frameworks. This paper discusses the problems and challenges in handling Big Data classification using geometric representation-learning techniques and the modern Big Data networking technologies. In particular this paper discusses the issues related to combining supervised learning techniques, representation-learning techniques, machine lifelong learning techniques and Big Data technologies (e.g. Hadoop, Hive and Cloud) for solving network traffic classification problems.
Modeling collaboration using shared objects (1999)

Many object-oriented toolkits and frameworks for groupware development provide shared objects as a basic service. This relieves developers of a lot of problems originating from the field of distributed systems. However, there is little support on how to use shared objects to actually build collaborative applications. In this paper we propose an object-oriented model for applications using shared objects. The model is discussed with respect to object-oriented reusability aspects and its applicability is tested against CSCW-specific aspects like the provision of group-awareness and coupling control. Furthermore, concrete model examples derived from an example application are shown for illustration.
Inhibition of Autoimmune Diabetes by Oral Administration of Anti-CD3 Monoclonal Antibody (2007)

Anti-CD3 monoclonal antibody (mAb) has been shown to induce tolerance and to be an effective treatment for diabetes both in animal models and in human trials. We have shown that anti-CD3 mAb given orally is biologically active in the gut and suppresses experimental autoimmune encephalitis by the induction of a regulatory T-cell that expresses latency-associated peptide (LAP) on its surface. In the present study, we investigated the effect of oral anti-CD3 mAb on the prevention of autoimmune diabetes in AKR mice in which the low-dose streptozocin (STZ) model induces autoimmunity to the beta-cells of the islets. We found that oral anti-CD3 mAb given at doses of 50 and 250 microg/feeding suppressed the incidence of diabetes in this model with the best effects seen at the 50 microg/dose. Associated with suppression, we observed decreased cell proliferation in the spleen and conversion of T-helper (Th)1 responses into Th2/Th3 responses in the periphery, including the pancreatic lymph nodes. Oral anti-CD3 mAb increased the expression of LAP on CD4(+) T-cells, and these cells could adoptively transfer protection. Protection by oral anti-CD3 was transforming growth factor-beta dependent. Our results demonstrate that oral anti-CD3 is effective in the model of STZ-induced diabetes and may be a useful form of therapy for type 1 diabetes in humans.
Mechanism of chain propagation in “living” polypropylene synthesis. <sup>1</sup>H and <sup>13</sup>C NMR analyses of chain‐end structures (1985)

Abstract The mechanism of chain propagation in the living coordination polymerization of propene initiated by the soluble V(acac) 3 /Al(C 2 H 5 ) 2 Cl catalyst was studied by 1 H and 13 C NMR analyses of iodine‐terminated polypropylenes of low molecular weights ( M n = 630 to 3200). A vanadium‐carbon bond in the living polypropylene end reacts quantitatively with the iodine molecule to yield a new iodine‐polymer bond. The 1 H and 13 C NMR analyses of iodine‐bonded polypropylene provide direct evidence on the stereochemistry of the first and last inserted propylene units and the structure of the living polypropylene end.
Impedance studies of wollastonite micro-fibre-reinforced cement paste systems (1993)

The impedance behaviour of wollastonite micro-fibre-reinforced cement-based composites at various degrees of hydration has been investigated. The observation of larger high-frequency arcs accompanying wollastonite micro-fibre addition to the Portland cement system at a hydration time greater than 3 days is an indication that the fibre matrix interface zone is less porous than the matrix itself. This conclusion is supported by SEM examination and porosimetry determinations. It is demonstrated that differences in the value of R 2 (the diameter of the high-frequency arc) for pastes with and without fibre reinforcement can be explained by the contribution to pore structure of both the fibre-cement interface and the cement matrix.
Upregulation of Mitimere and Nubbin acts through Cyclin E to confer self-renewing asymmetric division potential to neural precursor cells (2004)

In the Drosophila CNS, neuroblasts undergo self-renewing asymmetric divisions, whereas their progeny, ganglion mother cells (GMCs),divide asymmetrically to generate terminal postmitotic neurons. It is not known whether GMCs have the potential to undergo self-renewing asymmetric divisions. It is also not known how precursor cells undergo self-renewing asymmetric divisions. Here, we report that maintaining high levels of Mitimere or Nubbin, two POU proteins, in a GMC causes it to undergo self-renewing asymmetric divisions. These asymmetric divisions are due to upregulation of Cyclin E in late GMC and its unequal distribution between two daughter cells. GMCs in an embryo overexpressing Cyclin E, or in an embryo mutant for archipelago, also undergo self-renewing asymmetric divisions. Although the GMC self-renewal is independent of inscuteable and numb, the fate of the differentiating daughter is inscuteable and numb-dependent. Our results reveal that regulation of Cyclin E levels, and asymmetric distribution of Cyclin E and other determinants, confer self-renewing asymmetric division potential to precursor cells, and thus define a pathway that regulates such divisions. These results add to our understanding of maintenance and loss of pluripotential stem cell identity.
Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element (1993)

We have recently identified a complex transcriptional regulatory element in the medium chain acyl-CoA dehydrogenase (MCAD) gene promoter region that confers response to retinoids through interaction with receptors for all-trans-retinoic acid (RARs) and 9-cis-retinoic acid (RXRs) (Raisher, B. D., Gulick, T., Zhang, Z., Strauss, A. W., Moore, D. D., and Kelly, D. P. (1992) J. Biol. Chem. 267, 20264-20269). We examined the interaction of this element (RAREMCAD) with hepatocyte nuclear factor-4 (HNF-4), an orphan receptor with a tissue expression pattern similar to that of MCAD. Electrophoretic mobility shift assays and cotransfection experiments showed that HNF-4 binds with high affinity to RAREMCAD to activate transcription by an RXR-independent mechanism. Mutational analysis revealed that the MCAD HNF-4 response element consists of an imperfect direct repeat homologous to the consensus sequence for binding to the thyroid receptor/RAR/RXR subgroup of receptors and that distinct sequence requirements dictate HNF-4 binding and transactivation. Mobility shift assays with anti-HNF-4 antiserum demonstrated that the MCAD HNF-4 response element binds endogenous rat liver HNF-4 supporting its role in the regulation of MCAD gene expression in vivo. Thus, HNF-4 activates MCAD gene transcription via a complex regulatory element, the architecture of which carries important implications for the structure of HNF-4 response elements in general.
Proteolytically Degradable Hydrogels with a Fluorogenic Substrate for Studies of Cellular Proteolytic Activity and Migration (2005)

We have developed proteolytically degradable hydrogels with covalently immobilized fluorogenic protease substrates to visualize extracellular proteolytic activity and cell migration in three dimensions. Dye quenched-bovine serum albumin (DQ-BSA), a quenched, proteolytically activated fluorogenic substrate, was conjugated to poly(ethylene glycol) (PEG)-monoacrylate, and the product (DQ-BSA-PEG) was then covalently incorporated into proteolytically degradable and cell adhesive PEG hydrogels via photopolymerization. The DQ-BSA-PEG substrate in solution and incorporated into hydrogels exhibited significantly enhanced fluorescence after exposure to enzymes. Fibroblasts seeded within this hydrogel spread in three dimensions and extended lamellipodia. Cell migration and proteolytic activity were visualized using confocal microscopy. Proteolytic activity was concentrated near cell surfaces and remained present in the tracks where cell migration had occurred.
Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts (2010)

Y. lipolytica is the hemiascomycete with the most intron-rich genome sequenced to date, and it has several unusual genes with large introns or alternative transcription start sites, or introns in the 5' UTR. Our results suggest Y. lipolytica intron structure is subject to significant constraints, leading to the under-representation of stop-free introns. Consequently, intron-containing transcripts are degraded by a functional NMD pathway.
Constituents of Brazilian Geopropolis (1998)

Abstract Three samples of Brazilian geopropolis, collected by three indigenous bee species, were investigated by GC/MS. More than 50 compounds were identified, mainly terpenoids and phenolics. The chemical composition of propolis gathered by different bee species was different.
A well-defined metallocene catalyst supported on polystyrene beads (1998)

A spacer-modified polystyrene support with alcohol functionality was prepared using solid-phase organic reactions, and this resin was further derivatised to give a supported peralkylated titanocene which was active in ethylene polymerisation.
An Automated Electric Vehicle Prototype Showing New Trends in Automotive Architectures (2015)

The automotive domain is challenged by the increasing importance of Information Technology (IT) based functions. To show the possibilities of modern IT systems, a demonstrator car was developed in RACE (Robust and Reliant Automotive Computing Environment for Future eCars) based on a completely redesigned E/E architecture, which supports the integration of mixed-criticality components and offers features like Plug&Play. This paper presents the architecture and components of this vehicle prototype, which is equipped with modern systems such as Steer-by-Wire without mechanical fallback. It was designed to support future driver assistance systems, e.g. to carry out autonomous parking maneuvers onto an inductive charging station, a task, which is hard to achieve accurately enough for a human driver. Therefore, a special emphasis lies on the description of the sensor set for automated operation.
Diversity of Covalent Organic Frameworks (COFs): A 2D COF Containing Two Kinds of Triangular Micropores of Different Sizes (2015)

Although a lot of covalent organic frameworks (COFs) have been constructed over the past 10 years, the topologies of COFs are still quite limited. In this work, we report one-step construction of a COF with an unprecedented topology from the combination of C3-symmetrical and C2-symmetrical building blocks. It contains two types of triangular micropores of different sizes and chemical environments: one is 11.3 Å and the other is 15.2 Å. The structure of the dual-pore COF was confirmed by powder X-ray diffraction (PXRD) investigation, nitrogen adsorption–desorption study, and theoretical calculations.