gebhart/patrepeval huggingface dataset:
Toxicity of Copper and Ascorbic Acid to<i>Serratia marcescens</i> (1966)

Zimmerman, Leonard (Fort Detrick, Frederick, Md.). Toxicity of copper and ascorbic acid to Serratia marcescens. J. Bacteriol. 91:1537-1542. 1966.-Neutral solutions of ascorbic acid were antibacterial to Serratia marcescens at low but not at high population densities. The toxicity of ascorbate was eliminated by metal-sequestering treatments, and was restored only by the addition of trace amounts of copper salts. Copper-ascorbate was equally toxic under aerobic or anaerobic conditions; its toxicity was abolished by (i) chelating agents that sequestered the copper, (ii) metal-complexing agents that bound to the cells but did not sequester copper, and (iii) iron salts in the presence of air. On the basis of these observations, the toxic effects of copper-ascorbate were attributed to its reaction with vital Fe-containing cellular components.
Convexity (1958)

This account of convexity includes the basic properties of convex sets in Euclidean space and their applications, the theory of convex functions and an outline of the results of transformations and combinations of convex sets. It will be useful for those concerned with the many applications of convexity in economics, the theory of games, the theory of functions, topology, geometry and the theory of numbers.
The H3D Dataset for Full-Surround 3D Multi-Object Detection and Tracking in Crowded Urban Scenes (2019)

3D multi-object detection and tracking are crucial for traffic scene understanding. However, the community pays less attention to these areas due to the lack of a standardized benchmark dataset to advance the field. Moreover, existing datasets (e.g., KITTI) do not provide sufficient data and labels to tackle challenging scenes where highly interactive and occluded traffic participants are present. To address the issues, we present the Honda Research Institute 3D Dataset (H3D), a large-scale full-surround 3D multi-object detection and tracking dataset collected using a 3D LiDAR scanner. H3D comprises of 160 crowded and highly interactive traffic scenes with a total of 1 million labeled instances in 27,721 frames. With unique dataset size, rich annotations, and complex scenes, H3D is gathered to stimulate research on full-surround 3D multi-object detection and tracking. To effectively and efficiently annotate a large-scale 3D point cloud dataset, we propose a labeling methodology to speed up the overall annotation cycle. A standardized benchmark is created to evaluate full-surround 3D multi-object detection and tracking algorithms. 3D object detection and tracking algorithms are trained and tested on H3D. Finally, sources of errors are discussed for the development of future algorithms.
Patent claim decomposition for improved information extraction (2009)

In several application domains research in natural language processing and information extraction has spawned valuable tools that support humans in structuring, aggregating and managing large amounts of information available as text. Patent claims, although subject to a number of rigid constraints and therefore forced into foreseeable structures, are written in a language even good parsing algorithms tend to fail miserably at. This is primarily caused by long and complex sentences that are a concatenation of a multitude of descriptive elements. We present an approach to split patent claims into several parts in order to improve parsing performance for further automatic processing.
Investigating Critical Frequency Bands and Channels for EEG-Based Emotion Recognition with Deep Neural Networks (2015)

To investigate critical frequency bands and channels, this paper introduces deep belief networks (DBNs) to constructing EEG-based emotion recognition models for three emotions: positive, neutral and negative. We develop an EEG dataset acquired from 15 subjects. Each subject performs the experiments twice at the interval of a few days. DBNs are trained with differential entropy features extracted from multichannel EEG data. We examine the weights of the trained DBNs and investigate the critical frequency bands and channels. Four different profiles of 4, 6, 9, and 12 channels are selected. The recognition accuracies of these four profiles are relatively stable with the best accuracy of 86.65%, which is even better than that of the original 62 channels. The critical frequency bands and channels determined by using the weights of trained DBNs are consistent with the existing observations. In addition, our experiment results show that neural signatures associated with different emotions do exist and they share commonality across sessions and individuals. We compare the performance of deep models with shallow models. The average accuracies of DBN, SVM, LR, and KNN are 86.08%, 83.99%, 82.70%, and 72.60%, respectively.
Taxonomy of Fungi Causing Mucormycosis and Entomophthoramycosis (Zygomycosis) and Nomenclature of the Disease: Molecular Mycologic Perspectives (2012)

Molecular phylogenetic analysis confirmed the phylum Zygomycota to be polyphyletic, and the taxa conventionally classified in Zygomycota are now distributed among the new phylum Glomeromycota and 4 subphyla incertae sedis (uncertain placement). Because the nomenclature of the disease zygomycosis was based on the phylum Zygomycota (Zygomycetes) in which the etiologic agents had been classified, the new classification profoundly affects the name of the disease. Zygomycosis was originally described as a convenient and inclusive name for 2 clinicopathologically different diseases, mucormycosis caused by members of Mucorales and entomophthoramycosis caused by species in the order Entomophthorales of Zygomycota. Without revision of original definition, the name "zygomycosis," however, has more often been used as a synonym only for mucormycosis. This article reviews the progress and changes in taxonomy and nomenclature of Zygomycota and the disease zygomycosis. The article also reiterates the reasons why the classic names "mucormycosis" and "entomophthoramycosis" are more appropriate than "zygomycosis."
Isolation of umbilical cord mesenchymal stem cells using human blood derivatives accompanied with explant method (2019)

Our data suggest that, although all supplements maintain stemness characteristics of MSCs when used to isolate those cells by explant method, using human blood derived supplements is more effective than FBS. In the same context CBS is more effective than PL.
Doxazosin in the Treatment of Benign Prostatic Hyperplasia in Normotensive Patients: A Multicenter Study (1995)

A 16-week, double-blind, placebo controlled, dose titration study was done on 100 normotensive patients age 45 years or older to determine the efficacy and safety of doxazosin, a selective alpha 1-adrenoceptor antagonist, in the treatment of benign prostatic hyperplasia (BPH). Of the 41 efficacy evaluable patients 88% underwent dose titration to a maximum of 8 mg. doxazosin once daily. Maximum and average urinary flow rates increased significantly above baseline with doxazosin (2.9 ml. per second and 1.4 ml. per second, respectively) compared with placebo (0.7 ml. per second and 0.3 ml. per second, respectively). A significant effect on maximum flow rate was noted as early as week 2 of double-blind treatment at the initial efficacy evaluation. Doxazosin was superior to placebo in patient and investigator assessments of total, obstructive and irritative BPH symptoms. The onset of efficacy for total patient-assessed symptoms was significant for doxazosin compared to placebo 4 weeks after the start of the treatment regimen. Statistically significant decreases in mean blood pressure of 4 to 6 mm. Hg were noted with doxazosin compared with placebo. Adverse events, primarily mild to moderate in severity, were reported in 44% of patients given doxazosin and 30% of those given placebo. Our results strongly demonstrate that doxazosin is significantly superior to placebo in the treatment of BPH in normotensive patients, with the patient experiencing significant relief early after initiation of therapy.
Forests on the floodplain (2003)

Use of modern information and communication technology in hospitals facilitates access and transfer of information, and also accelerates patient's admission and discharge process, relation between hospital units, providing medical equipment supporting affairs' process and diagnostic procedures. However, modifying organizational policies, improve the infrastructure and enhancing nurses' motivation in documenting nursing reports can be effective in increasing the impact of information technology in care management processes especially in electronic record and nurse's clinical judgment and evidence-based care.
Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor (1995)

The substrate specificities of two human prohormone convertases, furin and PC1, were examined with a series of 7-amino-4-methylcoumarinamide (MCA) containing peptidyl substrates. Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys or Orn resulted for furin in a 538- and a 280-fold lower kcat/Km value, but only in a 14- and 18-fold decrease for PC1. Substitution of P3 Ser by either Pro, Glu, or Lys does not modify significantly the kcat/Km value for PC1, whereas furin activity is seriously impaired by the Glu substitution. Elongating the peptidyl sequence up to the P8 position decreases the kcat/Km value for furin but not for PC1. In both the P3 or P5 Glu substitution, the decrease of kcat/Km was due primarily to lower kcat rather than higher Km, possibly because of the presence of a negatively charged side chain. Finally, an octapeptidyl chloromethane derivative proved to be a potent irreversible inhibitor of either PC1 and ruin. The 811-fold difference in the apparent Kapp/[I] (1.63 x 10(6) s-1 m-1), and kcat/Km determined with the corresponding peptidyl MCA substrate (2.01 x 10(3) s-1 m-1), supports the proposal that cleavage of the acylenzyme represents the rate-limiting step for PC1 and furin.
Effective Data Gathering and Energy Efficient Communication Protocol in Wireless Sensor Network (2011)

Energy efficient data gathering is a common but critical operation in many applications of Wireless Sensor Networks (WSNs). Innovative energy efficient schemes that improve the sensor network lifetime are highly desirable. One of the energy efficient schemes in sensor network is clustering, which is an effective topology control strategy to increase network scalability and lifetime. In this paper we propose effective data gathering and energy efficient clustering scheme (EDGE) which ensures the equal distribution of cluster head responsibility among the sensor nodes and better suits the periodic data gathering applications. Our approach selects cluster head based on three metrics: sensor nodes current energy level, distance to base station and LEACH's probabilistic approach. We also propose two hop communication by selecting one gateway node. We simulate EDGE with two hop communication and without two hop communication. Simulation results shows that our approach significantly improve the network lifetime over Low Energy Adaptive Clustering Hierarchy (LEACH), LEACH-Centralized (LEACH-C) and Energy-LEACH (E-LEACH) algorithm especially when the first node runs out of energy.
Keystroke biometrics with number-pad input (2010)

Keystroke dynamics is the process of identifying individual users on the basis of their typing rhythms, which are in turn derived from the timestamps of key-press and key-release events in the keyboard. Many researchers have explored this domain, with mixed results, but few have examined the relatively impoverished territory of digits only, particularly when restricted to using a single finger - which might come into play on an automated teller machine, a mobile phone, a digital telephone dial, or a digital electronic security keypad at a building entrance. In this work, 28 users typed the same 10-digit number, using only the right-hand index finger. Employing statistical machine-learning techniques (random forest), we achieved an unweighted correct-detection rate of 99.97% with a corresponding false-alarm rate of 1.51%, using practiced 2-of-3 encore typing with outlier handling. This level of accuracy approaches sufficiency for two-factor authentication for passwords or PIN numbers.
Comparison of the anticalculus effect of two soluble pyrophosphate dentifrices with and without a copolymer. (1990)

A two phase, six month, double blind clinical study was conducted to compare the effect on supragingival calculus deposits of a dentifrice containing 1.30% soluble pyrophosphate (from 2.0% tetrasodium pyrophosphate) with and without the presence of 1.50% of a copolymer of methoxyethylene and maleic acid. In Phase I of the study, male and female adult subjects were stratified into two balanced groups according to baseline calculus scores. They received an oral prophylaxis and were assigned to the use of either a dentifrice containing 1.30% soluble pyrophosphate and 1.50% copolymer or to a placebo dentifrice that did not contain the anticalculus ingredients. After three months use of the products, the subjects received a calculus examination. The subjects were then entered into Phase II of the study where they were restratified into two balanced groups. They again received an oral prophylaxis and were assigned to the use of either a dentifrice containing 1.30% soluble pyrophosphate with no copolymer or to a placebo dentifrice. The results from the three month calculus examination indicated that the dentifrice containing soluble pyrophosphate and a copolymer reduced supragingival calculus deposits by 29.54%, as compared to the placebo dentifrice (less than 99% level of confidence). The results from the six month calculus examinations indicated that the dentifrice containing soluble pyrophosphate without the copolymer did not provide a statistically significant reduction in supragingival calculus after an oral prophylaxis. Thus, it is concluded that the presence of the copolymer in the soluble pyrophosphate dentifrice was essential for obtaining a statistically significant anticalculus effect.
Upper bounds on the probability of sequences emitted by finite-state sources and on the redundancy of the Lempel-Ziv algorithm (1992)

An upper bound on the probability of a sequence drawn from a finite-state source is derived. The bound is given in terms of the number of phrases obtained by parsing the sequence according to the Lempel-Ziv (L-Z) incremental parsing rule, and is universal in the sense that it does not depend on the statistical parameters that characterize the source. This bound is used to derive an upper bound on the redundance of the L-Z universal data compression algorithm applied to finite-state sources, that depends on the length N of the sequence, on the number K of states of the source, and, eventually, on the source entropy. A variation of the L-Z algorithm is presented, and an upper bound on its redundancy is derived for finite-state sources. A method to derive tighter implicit upper bounds on the redundancy of both algorithms is also given, and it is shown that for the proposed variation this bound is smaller than for the original L-Z algorithm, or every value of N and K.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An <i>Arabidopsis</i> mutant defective in UV‐B light‐mediated responses (2003)

In plants, low fluences of ultraviolet-B radiation (UV-B; 280-320 nm) trigger the activation of protection mechanisms and various photomorphogenic responses. We established a novel screen to isolate Arabidopsis T-DNA mutants (uli, UV-B light insensitive) with reduced sensitivity towards UV-B light-mediated inhibition of hypocotyl growth. One of the mutants, uli3, shows also a reduced sensitivity of UV-B-induced gene expression events and was, therefore, chosen for further investigation. The ULI3 gene encodes an 80-kDa protein with potential domains for heme- and diacylglycerol-binding. In transiently transfected protoplasts, the ULI3:GFP fusion protein is localised in the cytoplasm but also adjacent to membranes. In etiolated Arabidopsis seedlings irradiated by UV-B, ULI3 mRNA expression is strongly up-regulated. This is caused by elevated transcription as demonstrated using stable transformants where a GUS-reporter was driven by the ULI3-promoter. ULI3 is preferentially expressed in the outer cell layers in leaves, stems and flowers, but not in roots. There is evidence that ULI3 represents a specific component involved in UV-B-mediated signal transduction in higher plants.
The Effect of Customized Insoles on the Reduction of Postwork Discomfort (2001)

This study examined the effect of customized insoles in relieving postwork discomfort in healthy individuals whose jobs require long periods of standing and walking. CompuSole insoles were worn by 122 New York City Police Department officers for up to 5 weeks for an average of 7 hours per day. The officers walked an average of 3 miles per day. Before the study, one-fifth of the police officers in this study experienced foot pain or discomfort at the end of their workday; 15% had calluses, corns, or athlete's foot; 18% had sought treatment for a foot problem in the past; and 20% had worn foot orthoses. There was a significant reduction in tiredness in the feet at the end of the day after wearing the insoles, but no improvement in back or leg discomfort. At the end of the workday, 68% had less foot discomfort and 60% were more comfortable at work when wearing the insoles.
Characterization of the co‐elution of host cell proteins with monoclonal antibodies during protein A purification (2016)

Protein A chromatography is commonly used as the initial step for purifying monoclonal antibody biotherapeutics expressed in mammalian tissue culture cells. The purpose of this step, as well as later chromatography steps, is, in part, to remove host cell proteins (HCPs) and other related impurities. Understanding the retention mechanism for the subset of HCPs retained during this step is of great interest to monoclonal antibody (mAb) process developers because it allows formation of a guided HCP clearance strategy. However, only limited information is available about the specific HCPs that co-purify with mAbs at this step. In this study, a comprehensive comparison of HCP subpopulations that associated with 15 different mAbs during protein A chromatography was conducted by a 2D-LC-HDMS(E) approach. We found that a majority of CHO HCPs binding to and eluting with the mAbs were common among the mAbs studied, with only a small percentage (∼10% on average) of a mAb's total HCP content in the protein A (PrA) eluate specific for a particular antibody. The abundance of these HCPs in cell culture fluids and their ability to interact with mAbs were the two main factors determining their prevalence in protein A eluates. Potential binding segments for HCPs to associate with mAbs were also studied through their co-purification with individual Fc and (Fab')2 antibody fragments. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:708-717, 2016.
Understanding CMP-induced delamination in ultra low-k/Cu integration (2005)

In-situ friction characterization during chemical-mechanical polishing (CMP) was investigated to understand delamination mechanisms of a porous ultra low-k (ULK)/Cu stack. By quantifying the delaminated area within the wafer, it was shown that adhesion failure is driven by the work done against the CMP-induced friction force, and is correlated to the adhesion strength of the weakest interface. A low-stress CMP was successfully achieved on a first level of ULK/Cu interconnects having a low adhesion SiC/ULK interface (Gc=1.3 J/m/sup 2/) and a porous dielectric material with low mechanical properties (Young's modulus E=3.5 GPa, hardness H=0.7 GPa).
Dipyridamole augments the antitumor effects of fluorinated pyrimidines. (1992)

The antitumor effects of 5-fluorouracil (5-FU) and its analogues when combined with dipyridamole (DP) were investigated using B16 melanoma cells, in vitro and in vivo. First, the enhancement of 5-FU cytotoxicity by DP was examined in vitro. Cell growth was suppressed significantly by combining 5-FU and a nontoxic dose of DP (2.5 micrograms/ml) as compared to 5-FU alone. Next, the effect of DP was examined in vivo in combination with 5-FU, tegafur (FT) and UFT. UFT had the most remarkable antitumor effect when given in a single equimolar dose. Although DP alone did not affect tumor growth, the growth inhibition by antitumor drugs was augmented by DP. DP enhanced the antitumor effect of UFT significantly (P less than 0.05), and combination treatment with UFT and DP proved to be the most effective regimen for inhibiting growth of B16 melanoma. Combination treatment with UFT and DP shows promise for clinical cancer.
Post-Layout Parasitic Verification Methodology for Mixed-Signal Designs Using Fast-Spice Simulators (2006)

Current sub-100 nanometer processes employ complex multilayer metallization structures with advanced dielectric materials. Closely-spaced thin, tall metal interconnects with low voltage and fast-clocking edges lead to circuit performances dominated by parasitic delays. Various issues such as noise and delay associated with cross-talk due to coupling capacitances; IR drop effects in the low power supply operating regimes; high current density causing electromigration in narrow interconnect structures; and DC path leakage currents are becoming very common effects in recent mixed-signal designs. Full-chip, post-layout simulation with extracted parasitic components is required in the design flow to accurately analyze each of these effects. Due to the presence of a large amount of parasitics, it is important to extract appropriate parasitics for the relevant process corners and perform the analysis. Fast-spice simulator-based flows are becoming prevalent due to their capacity and efficiency in handling large amounts of data. In this paper, we discuss various options available for designers using fast-spice simulators (e.g. UltraSim, NanoSim, and HSIM) for post-layout simulations, and how these options affect the end results. We have simulated the design with 2.5 million RC elements in 13 hours using a fast-spice simulator. A few examples of post-layout simulations carried out on designs will be discussed.
The I/O Performance of Multiway Mergesort and Tag Sort (1985)

We develop models of secondary storage to evaluate external sorting and use them to analyze the average I/O access time of mergesort and tag sort on files with uniform key distribution. The k-way mergesort takes [log <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</inf> R] merge passes to sort a file with R initial sorted runs. Choosing k as large as possible reduces the number of merge passes, but we show that under the assumptions of our models, the I/O access time of the merge phase in mergesort increases as a function of k. For large files with short keys, tag sort provides a promising alternative to mergesort. We analyze the I/O access time of tag sort with a ``sequential scan'' distribution method. We show that for large files tag sort takes asymptotically less I/O time than mergesort.