gebhart/patrepeval huggingface dataset:
Differential Requirement for a Cellular Type-1 Immune Response in Tumor-Associated Versus Alloantigen-Targeted GvT Effects (2007)

Compared with syngeneic F1-into-F1 controls (F1[H-2(b/d)] --> F1: MethA[H-2d]), significant T cell-mediated GvT effects occurred in both allogeneic transplant models, even in the absence of histoincompatibilities between donor cells and host tumor (BALB/c[H-2d] --> F1: MethA[H-2d]). Selective inhibition of type-1 (Th-1/Tc1) immune responses with TAK-603 after HSCT nearly abolished GvHD in both allogeneic transplant models. While GvT effects directed against alloantigens (C57BL/6[H-2b] --> F1: MethA[H-2d]) remained unaffected during type-1-immune suppression, GvT effects targeted against tumor-associated antigens (BALB/c[H-2d] --> F1: MethA[H-2d]) were not evident. CONCLUSIONS.: Our data show that GvHD and GvT effects are in principle separable from each other by selective type-1 inhibition in transplantation models with major histocompatibility complex disparities between tumor, host, and donor. In contrast, in situations that only allow for GvT effects that exclusively target tumor-associated antigens (TAAs), type-1 inhibition results in complete abrogation not only of GvHD but also desired GvT reactions. These differences in GvT effects targeting alloantigens or TAAs and their interrelation to GvHD should be considered in future studies aimed at separating GvT reactions from GvHD.
Stable and Efficient Paclitaxel Nanoparticles for Targeted Glioblastoma Therapy (2015)

Development of efficient nanoparticles (NPs) for cancer therapy remains a challenge. NPs are required to have high stability, uniform size, sufficient drug loading, targeting capability, and ability to overcome drug resistance. In this study, the development of a NP formulation that can meet all these challenging requirements for targeted glioblastoma multiform (GBM) therapy is reported. This multifunctional NP is composed of a polyethylene glycol-coated magnetic iron oxide NP conjugated with cyclodextrin and chlorotoxin (CTX) and loaded with fluorescein and paclitaxel (PTX) (IONP-PTX-CTX-FL). The physicochemical properties of the IONP-PTX-CTX-FL are characterized by transmission electron microscope, dynamic light scattering, and high-performance liquid chromatography. The cellular uptake of NPs is studied using flow cytometry and confocal microscopy. Cell viability and apoptosis are assessed with the Alamar Blue viability assay and flow cytometry, respectively. The IONP-PTX-CTX-FL had a uniform size of ≈44 nm and high stability in cell culture medium. Importantly, the presence of CTX on NPs enhanced the uptake of the NPs by GBM cells and improved the efficacy of PTX in killing both GBM and GBM drug-resistant cells. The IONP-PTX-CTX-FL demonstrated its great potential for brain cancer therapy and may also be used to deliver PTX to treat other cancers.
Safe peer-to-peer self-downloading (2008)

A goal of peer-to-peer applications is to share files between users themselves rather than downloading files from file servers. Self-downloading protocols have the property that, eventually, every user downloads only from other users. Self-downloading is problematic if users disconnect from the system upon completing file downloading, because they only share with other users while connected. Yet, if users continue to arrive at a sufficient rate, self-downloading protocols are possible. One vulnerability of file sharing between users is the possibility that files or segments could be counterfeit or corrupt. Protocols that are d -safe tolerate some number of instances of faulty segments in a file being downloaded, because each segment is downloaded d times before being shared. This article shows that d -safe self-downloading is possible for a sufficiently large arrival rate of users to the system. Upper and lower connectivity and sharing bounds are given for d = 2, and simulation results show effects of relaxing assumptions about arrival rates and bandwidth.
Proteolytic activity and reduction of gliadin-like fractions by sourdough lactobacilli (2005)

This work provides new information of use when obtaining sourdough starters for bread making. Moreover, knowledge regarding lactobacilli capable of reducing the level of gliadin-like fractions, a toxic peptide for coeliac patients, has a beneficial health impact.
Synthesis of Crown Ethers Containing a Rubicene Moiety (2000)

A symmetrically disubstituted derivative of the highly fluorescing and photostable rubicene was incorporated in a macrocycle using high dilution conditions and a hydroxyrubicene was functionalized with a modified aminobenzo-15-crown-5.
Previous Psychotherapy among Hypnotherapy Applicants (1974)

Abstract Presenting problem and reported previous psychotherapy were analyzed in a sample of 413 applicants for hypnotherapy clinic treatment. A significant relationship (p < .001) was found between type of problem and report of previous psychotherapy. Applicants stating problems usually associated with analytic psychotherapy (anxiety, depression) tended to have higher rates of previous psychotherapy than applicants presenting problems more often associated with treatment by direct suggestion (obesity, pain, smoking). Applicants for treatment by analytic hypnotherapy were more often referred professionally (by doctors or agencies), and less often through the popular media, than patients seeking symptom removal through suggestion.
Method for linearising analogue DFB lasers usinganintegrated MQW electroabsorption modulator (1996)

The linearity of narrow-band RF and microwave analogue optical transmitters can be improved by re-modulating their output by using an intensity modulator with controllable nonlinearity. The authors demonstrate linearisation of a distributed feedbaek (DFB) laser using a monolithically-integrated electroabsorption (EA) modulator. The spurious-free dynamic range of an unoptimised device is increased from 96 dBm/Hz2/3 to 117 dBm/Hz6/7.
jian hao cun zhi bu ti qian da xiao kang (1998)

近几年来,江苏省东台市委以提前达小康,加快农村现代化进程为目标,不断加大农村基层组织建设工作的领导力度,农村党支部建设水平得到提高,带领农民群众奔小康的凝聚力、战斗力和号召力明显增强,初步走出一条欠发达地区通过加强农村基层组织建设,提前达小康的路子。1996年该市农村全面达小康,成为江苏省首批达小康的县(市)之一;1997年全市农村三业总产值达到120.86亿元,农民人均纯收入达到3295元,年末农村储蓄余额36.5亿元。全国农村基层组织建设联系会议办公室主任、中组部原部务委员刘俊林到该市考察时,充分肯定了他们的做法。1、以选优配强党支部书记为
Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency. (1986)

The metabolic causes for immune impairment in patients with severe chronic inflammatory diseases have not been clearly defined. Recently, the overproduction of poly(ADP-ribose) in resting lymphocytes with unrepaired DNA strand breaks has been suggested to contribute to immune dysfunction in adenosine deaminase-deficient patients. Our experiments have determined to what extent DNA damage and poly(ADP-ribose) synthesis might also explain the impaired mitogen responsiveness of PBL exposed to toxic oxygen species. Treatment of normal resting human lymphocytes with xanthine oxidase and hypoxanthine dose-dependently induced DNA strand breaks and triggered the rapid synthesis of poly(ADP-ribose). Subsequently, NAD+ and ATP pools decreased precipitously. Lymphocytes exposed previously to the enzymatic oxidizing system did not synthesize DNA after stimulation with PHA. However, if the medium was supplemented with 3-aminobenzamide or nicotinamide, two compounds that inhibit poly(ADP-ribose) formation, cellular NAD+ and ATP pools were preserved, and the lymphocytes responded vigorously to a mitogenic challenge. Excessive poly(ADP-ribose) synthesis, provoked by DNA strand breakage, may represent a common pathway that connects the immunodeficiency syndromes associated with (a) exposure of lymphocytes to toxic oxygen species during chronic inflammatory states, (b) adenosine deaminase deficiency, and (c) certain DNA repair disorders.
Synthesis and Anti-HIV Activity of 6-Substituted Purine 2′-Deoxy-2′-fluororibosides (1994)

Abstract 3′,5′-Di-O-protected 6-chloropurine arabinoside 4b was treated with diethylaminosulfur trifluoride (DAST) and subsequently deprotected with pyridinium p-toluenesulfonate to give 6-chloropurine 2′-deoxy-2′-fluororiboside 6a. The displacement with nucleophile afforded the 6-substituted congener 6b-e. Treatment of 5′-O-protected 6-chloropurine arabinoside 3c with DAST gave lyxoepoxide 7.
AN IMPLEMENT TO INSTALL AND RETRIEVE SURFACE DRIP IRRIGATION LATERALS (2004)

A surface drip irrigation tape installer/retriever was developed for small fields. One operator can install driptapes on or just beneath the soil surface to precisely irrigate crops after planting and retrieve the drip tapes after irrigationis no longer needed for the season. The implement is mounted to the tractor using a three-point hitch and performs bothfunctions of installation and retrieval of drip tapes in one unit. The retriever mainly consists of a speed reducer, a powertransmission line, a drip tape distributor, drip tape spool supporters, water extractors, tensioners, and drip tape guides. Theinstaller mainly consists of a chisel, a press wheel, a tape depth adjustment screw, a tension spring, two soil cover plates, anda tangling prevention ring holder. During the installation process, drip tapes are placed in shallow trenches cut by the 5-cmwide chisel and are covered with soil by 6.5-cm wide pneumatic wheels. The depth of drip tapes can be adjusted from 0 to5 cm beneath the soil surface. During the drip tape retrieval process, drip tapes are distributed evenly across rotating spoolswhile any water in the tapes is squeezed out. The retrieval speed is adjusted by changing the tractor PTO speed. To retrieveexcess disposable drip tapes, a special spool was developed to quickly remove the tapes from the unit. No tools are neededfor either installing or removing drip tape spools. Mathematical models were developed to calculate drip tape length,retrieving time, and spool sizes. Speeds of both retrieval and installation increased as the total number of laterals per hadecreased, or as the field length increased.
Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line (2002)

Human papillomaviruses (HPVs) are aetiological agents of human malignancies, most notably cervical cancers. The life-cycles of HPVs are dependent on epithelial differentiation, and this has impeded many basic studies of HPV biology. The organotypic (raft) culture system supports epithelial differentiation such that infectious virions are synthesized in raft tissues from epithelial cells that replicate extrachromosomal HPV genomes. The CIN-612 9E cell line maintains episomal copies of HPV type 31b (HPV31b), an HPV type associated with cervical cancers. Many previous studies, including our own, have focused on characterizing the later stages of the HPV31b life-cycle in CIN-612 9E raft tissues. In this study, we have used the raft system to generate large numbers of HPV31b viral DNA (vDNA)-containing particles. We found a biologically contained homogenization system to be efficient at virion extraction from raft epithelial tissues. We also determined that vDNA-containing particles could be directly quantified from density-gradient fractions. Using an RT-PCR assay, the presence of newly synthesized, spliced HPV31b transcripts was detected following HPV31b infection of the immortalized HaCaT epithelial cell line. Spliced E6 and E1( wedge )E4 RNAs were detected using a single round of RT-PCR from cells infected with a dose as low as 1.0 vDNA-containing particle per cell. Spliced E1*I,E2 transcripts were found in cells infected with an HPV31b dose as low as 10 vDNA-containing particles per cell. Infectivity was blocked by HPV31 antiserum, but was not affected by DNase I. This work lays a foundation for a detailed analysis of the early events in HPV infection.
Public Building in a Parliamentary State (1985)

(1985). Public Building in a Parliamentary State. The London Journal: Vol. 11, No. 1, pp. 3-27.
Guided wave travel time tomography for bends (2013)

The concept of predictive maintenance using permanent sensors that monitor the integrity of an installation is an interesting addition to the current method of periodic inspections. Guided wave tomography has been developed to map the wall thickness using the travel times of guided waves. The method has been demonstrated to work well for straight pipes. The extension of this method to bends is not straightforward because natural focusing that occurs due to geometrical path differences. This yields a phase jump, which complicates travel time picking. Because ray-tracing is no longer sufficient to predict the travel times a recursive wave field extrapolation has been developed. The method uses a short spatial convolution operator to propagate a wave field through a bend. The method allows to calculate the wave field at the detector ring, including the phase jump as a consequence of the natural focusing. The recursive wave field extrapolation is done in the space-frequency domain. Therefore dispersion effects can be included easily in the forward modeling. Comparison with measurements shows the accuracy of the method. An improved tomographic inversion scheme has been implemented using the extrapolation method as forward modeling kernel. The results show that is it possible to reconstruct defects independent of their location on the bend. The method is not limited to 90° bends but works on any bend angle, including straight pipes.
Composite Iterative Algorithm and Architecture for q-th Root Calculation (2011)

An algorithm for the q-th root extraction, q being any integer, is presented in this paper. The algorithm is based on an optimized implementation of X^{1/q} by a sequence of parallel and/or overlapped operations: (1) reciprocal, (2) digit-recurrence logarithm, (3) left-to-right carry-free multiplication and (4) on-line exponential. A detailed error analysis and two architectures are proposed, for low precision q and for higher precision q. The execution time and hardware requirements are estimated for single precision floating-point computations for several radices, this helps to determine which radices result in the most efficient implementations. The architectures proposed improve the features of other architectures for q-th root extraction.
Addendum: ‘‘Carrier concentration and activation energy in heavily donor-doped silicon’’ [J. Appl. Phys. <b>6</b> <b>1</b>, 591 (1987 )] (1988)

In a previous paper [D. Schechter, J. Appl. Phys. 61, 591 (1987)] the Lee–McGill model for computing the populations and carrier concentrations in heavily doped n-type silicon was systematically explored. In this addendum, the carrier concentration calculated using the Lee–McGill model is calculated as the doping density is decreased, and is compared with that calculated using the usual dilute doping model. In particular, the extent to which the predictions of the two models agree is explored. It is found that at room temperature the two models agree very closely for doping concentrations below 1×1017 cm−3, but at reduced temperatures the coincidence is not so close.
Stabilization of intense coasting beams in particle accelerators by means of inductive walls (1966)

A method for stabilizing a relativistic coasting beam against the negative mass instability is described. It is shown that a beam above the transition energy can be stabilized, even in the absence of a frequency spread in the beam, by making the wave impedance at the beam inductive. Several possible structures that can result in such an inductive impedance are described, and the case of a thin dielectric material positioned against the tank wall is analysed in detail. The effect of the dielectric wall on the longitudinal and transverse resistive instabilities is considered. It is shown that the dielectric can also play an important role in the stability criteria for these resistive modes, and in some cases can make the requirements on the frequency spread for stability less stringent. Several numerical examples are given to illustrate the typical range of the parameters involved.
Acyclic Diamino Carbene Complexes of Manganese(I): Synthesis, Deprotonation, and Subsequent Multiple Insertion Reaction of Alkynes (2009)

The cationic isocyanide complexes fac-[Mn(CNR)(CO)3(bipy)]+ (1) react with NH2CH3 to give acyclic diaminocarbene (ADC) complexes fac-[Mn(ADC)(CO)3(bipy)]+ (2), which when treated with KOH yield neutral formamidinyl (ADC-H) derivates fac-[Mn(ADC-H)(CO)3(bipy)] (3). These undergo multiple insertion reactions of methyl propiolate or phenyl acetylene into the metal−carbon bond to afford compounds 4 and 5 containing a new η4-azacyclohexadienyl ligand, with the loss of the bipy chelating ligand.
CASEIN and Its Industrial Applications (1943)

RETURN TO ISSUEPREVNewsNEXTCASEIN and Its Industrial ApplicationsEDWIN SUTERMEISTER and FREDERICK L. BROWNECite this: Chem. Eng. News 1943, 21, 1, 43Publication Date (Print):January 10, 1943Publication History Published online4 November 2010Published inissue 10 January 1943https://pubs.acs.org/doi/10.1021/cen-v021n001.p043https://doi.org/10.1021/cen-v021n001.p043newsACS PublicationsCopyright © 1943 American Chemical SocietyArticle Views9Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Peptides and proteins Get e-Alerts
Transmission of single-carrier 400G signals (5152-Gb/s) based on 1288-GBaud PDM QPSK over 10,130- and 6,078 km terrestrial fiber links (2015)

We experimentally demonstrate the coherent transmission system with the highest ETDM-based symbol rate of 128.8-GBaud over record breaking distances. We successfully transmitted single-carrier 515.2-Gb/s PDM-QPSK/9-QAM signals over 10,130km/6,078-km, respectively, over 100km spans of TeraWave SLA + fiber. To the best of our knowledge, it is the highest ETDM-based symbol rate reported so far, and the longest WDM transmission distance with single-carrier 400G signals. For the first time, the 515.2-Gb/s single-carrier PDM-QPSK signals in 200-GHz-grid are successfully transmitted over distance above 10,000km in terrestrial transmission environment. We have also demonstrated the transmission of single carrier 128.8-GBaud filtered QPSK signals in 100-GHz-grid over 6,078-km, which has the line spectral efficiency (SE) of 5.152 (b/s/Hz).
Role of electric field on formation of silicon nanowires (2003)

An electric-field mechanism has been developed to explain the oxide-assisted growth of silicon nanowires. This mechanism assumes a strong electric field at the tip of silicon nanowires. Most of the SiO molecules would be attracted by this electric field and then land on the nanowire tip. Thus, the silicon nanowire growth is restricted at the tip only. The maximum electric field that could possibly exist has been estimated from the field emission data. The probability of SiO vapor landing on the nanowire tip is calculated for a wide range of conditions. The result shows that for a sufficiently strong electric field, all SiO vapor would land on the nanowire tip. This attractive force to the nanowire tip is even more pronounced if the SiO vapor first condenses to form a larger cluster. All these calculation results suggest that this electric-field mechanism is possible.
Perioperative Glucose and Insulin Administration While Maintaining Normoglycemia (GIN Therapy) in Patients Undergoing Major Liver Resection (2010)

GIN therapy effectively provides normoglycemia in patients undergoing liver resection (clinicaltrials.gov, NCT00774098).
Vision-based control of 3D facial animation (2003)

Controlling and animating the facial expression of a computer-generated 3D character is a difficult problem because the face has many degrees of freedom while most available input devices have few. In this paper, we show that a rich set of lifelike facial actions can be created from a preprocessed motion capture database and that a user can control these actions by acting out the desired motions in front of a video camera. We develop a real-time facial tracking system to extract a small set of animation control parameters from video. Because of the nature of video data, these parameters may be noisy, low-resolution, and contain errors. The system uses the knowledge embedded in motion capture data to translate these low-quality 2D animation control signals into high-quality 3D facial expressions. To adapt the synthesized motion to a new character model, we introduce an efficient expression retargeting technique whose run-time computation is constant independent of the complexity of the character model. We demonstrate the power of this approach through two users who control and animate a wide range of 3D facial expressions of different avatars.
An improved high power factor and low cost three-phase rectifier (2002)

A new method to improve the power factor of three-phase rectifiers is introduced in this paper. The main features of the proposed circuit are low cost, small size, high efficiency and simplicity. The power factor improvement is achieved with three bidirectional active switches rated at a small fraction of the total processed power, and gated at the line frequency. Principle of operation and design procedure, with practical examples are also presented. The theoretical analysis was validated with experimental results from a laboratory prototype rated at 6.4 kW and connected to the 220 V, 60 Hz AC system. The same circuit was also used in another prototype rated at 12 kW, with similar results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Exploring the Structural Diversity of Mammalian Carbohydrates (“Glycospace”) by Statistical Databank Analysis (2007)

The diversity of three major classes of mammalian carbohydrates, mainly glycolipids and O- and N-linked glycans, deposited in the databank GLYCOSCIENCES.de was subjected to statistical analyses. Size, chain length, and branching complexity were accessed and revealed that the average oligosaccharide is composed of about eight monosaccharide units. About a quarter of all oligosaccharides are strictly linear, and the remainder are branched at least once. Glucosamine, galactose, and mannose are dominating and comprise ~75% of the monosaccharides within mammalian oligosaccharide frameworks. alpha-Linked sialic acid, alpha-linked fucose, and beta-linked galactose decorate the majority of reducing termini. Glucose as the most abundant carbohydrate in mammals plays only a very minor role within these structures. Particular emphasis was placed on analyzing the way the monosaccharide units are linked within the oligomeric framework. Just 11 monosaccharide connections account for >75% of all linkages. Thus, the number of structural combinations found in nature, the part of the occupied mammalian glycospace, is much smaller than expected. As a result, a potential set of building blocks for oligosaccharide assembly is presented. This potential building block set was correlated with the accessible 3299 mammalian carbohydrate structures in the GLYCOSCIENCES.de databank. Only 36 building blocks are required to construct 75% of the 3299 mammalian oligosaccharides.