gebhart/patrepeval huggingface dataset:
A Randomized, Evaluator-Blind, Multicenter Comparison of the Efficacy and Tolerability of Perlane versus Zyplast in the Correction of Nasolabial Folds (2005)

Bovine collagen is widely used as a dermal filler for facial soft-tissue augmentation, but it provides only temporary cosmetic improvement. Nonanimal stabilized hyaluronic acid has reduced potential for immunogenicity and hypersensitivity and may provide a more durable aesthetic result. Sixty-eight patients with prominent nasolabial folds were randomized to intradermal treatment with nonanimal stabilized hyaluronic acid gel (Perlane) and bovine collagen (Zyplast) on contralateral sides of the face. On achievement of "optimal cosmetic result" (baseline), patients were followed up for 6 months; bilateral retreatment with Perlane was offered at 6 or 9 months after baseline. Responses were evaluated at 2, 4, 6, 9, and 12 months after baseline. Investigator-based and patient-based ratings indicated that Perlane was more effective than Zyplast in maintaining cosmetic correction. According to investigator-based Wrinkle Severity Rating Scale assessments at 6 and 9 months after baseline, Perlane was superior in 50.0 percent and 48.8 percent of patients, respectively, whereas Zyplast was superior in 10.3 percent and 14.0 percent of patients, respectively (p < 0.0004). Investigator-based Global Aesthetic Improvement Scale assessment at 9 months after baseline indicated that Perlane was superior in 48.8 percent of patients, whereas Zyplast was superior in 14.0 percent of patients (p = 0.0025). "Optimal cosmetic result" was achieved with a smaller volume of Perlane than Zyplast (mean, 1.2 ml versus 2.1 ml). Local injection-site reactions (redness, swelling, pruritus, and induration) were less frequent with Perlane than with Zyplast. Delayed-onset reactions were rare and did not reoccur after Perlane retreatment. Perlane has acceptable long-term safety and offers a longer-lasting aesthetic improvement than Zyplast.
R. L. Moore’s axiom 1′ and metrization (1958)

Let S be a Hausdorff space for which there exists a simple sequence G1, G2, -of open coverings such that (1) for each n, GnDG1+,, and (2) if H and K are nonintersecting closed subsets of S one of which is compact, then for some n no element of G. intersects both H and K.2 At the 1957 Summer Meeting of the Society the question arose in connection with M1r. Armentrout's paper, A study of certain plane-like spaces without thve use of arcs,3 as to whether or not S when satisfying certain rather complicated axioms was metric. I remarked that there did exist such nonmetric spaces. This observation was incorrect.
A Study on the Efficient Removal of CO<sub>2</sub> from a Coal Gasification Combined Cycle Plant (1992)

Degradation of the global environment is one of the most crucial issues in the energy field. In particular, the global warming is a serious problem because the carbon dioxide produced by burning fossil fuels is a dominant source of anthropogenic greenhouse gas emissions. We need to develop technologies of controling CO2 emissions to mitigate the global warming. This paper presents a novel system of removing CO2 efficiently from power stations. We focus the research on the coal gasification combined cycle plant, and propose the system in which CO2 is removed from the fuel gas utilizing the shift reaction before the gas is burnt to generate electricity. We have computed thermal efficiencies in the following two types of combined cycle plants. One is the plant in which CO2 is removed from the fuel gas before the gas is burnt. The other is the plant in which CO2 is removed from the stack gas after the gas is burnt. Computed results show that the efficiency is higher by 2.6 percentage points in the plant of removal before burning than in the plant of removal after burning.
Increased Overall Antibiotic Susceptibility in <i>Staphylococcus aureus femAB</i> Null Mutants (1998)

The staphylococcal pentaglycine side chain of the peptidoglycan is reduced to one glycine in femAB null mutants. This is associated with increased susceptibility to methicillin and to a whole range of unrelated antibiotics as well. Genetic evidence suggests that femAB null mutants are only viable because of a compensatory mutation in an unlinked site.
Information Security Continuous Monitoring (ISCM) for federal information systems and organizations (2011)

The Information Technology Laboratory (ITL) at the National Institute of Standards and Technology (NIST) promotes the U.S. economy and public welfare by providing technical leadership for the nation's measurement and standards infrastructure. ITL develops tests, test methods, reference data, proof of concept implementations, and technical analyses to advance the development and productive use of information technology. ITL's responsibilities include the development of management, administrative, technical, and physical standards and guidelines for the cost-effective security and privacy of other than
생물학적 질소·인 제거를 위한 SMMIAR(Submerged Moving Media Intermittent Aeration Reactor) 공정의 운전 특성 (2003)

This study was carried out to obtain the operating characteristics of SMMIAR process for biological nitrogen phosphours removal. SMMIAR was operated at HLR(Hydraulic loading rate) of 39.6, 52.8, 63.4 and 79.2 l/㎥/d respectively and the operating parameters such as intermittent aeration tine ratio of aerobic/anoxic, DO and microorganism concentration were change to confirm the optimum operating condition. The concentration wastewater BOD, TN(Total nitrogen) and TP(Total phosphours) were 150, 30 and 7.5㎎/l respectively. Achieving better removal effciencies of BOD, TN and TP up to 90,85.4 and 95.4% respectively, we must keep in operation condition of SMMIAR by 0.75 of time ratio of aerobic/anoxie and by minimum 45 minutes of oxic period simltaneously.
Fiber-Optic Sensor Systems For Aerospace Applications (1988)

Advanced aircraft and spacecraft will require fiber-optic sensor systems to monitor the environment around the platform as well as the structural integrity of the vehicle itself. These sensors when embedded in composite or metal matrix material can also be used to monitor the manufacturing process. Thus, this technology provides a means to sense key environmental parameters from the creation of parts, through assembly, test and flight for the life of the platform.
Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine–Mediated Cell Killing <i>In vitro</i> and <i>In vivo</i> (2009)

Cytosine deaminase is used in combination with 5-fluorocytosine as an enzyme-prodrug combination for targeted genetic cancer treatment. This approach is limited by inefficient gene delivery and poor prodrug conversion activities. Previously, we reported individual point mutations within the substrate binding pocket of bacterial cytosine deaminase (bCD) that result in marginal improvements in the ability to sensitize cells to 5-fluorocytosine (5FC). Here, we describe an expanded random mutagenesis and selection experiment that yielded enzyme variants, which provide significant improvement in prodrug sensitization. Three of these mutants were evaluated using enzyme kinetic analyses and then assayed in three cancer cell lines for 5FC sensitization, bystander effects, and formation of 5-fluorouracil metabolites. All variants displayed 18- to 19-fold shifts in substrate preference toward 5FC, a significant reduction in IC(50) values and improved bystander effect compared with wild-type bCD. In a xenograft tumor model, the best enzyme mutant was shown to prevent tumor growth at much lower doses of 5FC than is observed when tumor cells express wild-type bCD. Crystallographic analyses of this construct show the basis for improved activity toward 5FC, and also how two different mutagenesis strategies yield closely related but mutually exclusive mutations that each result in a significant alteration of enzyme specificity.
A Model-Based Gaze Tracking System (1997)

In this paper we present a non-intrusive model-based gaze tracking system. The system estimates the 3-D pose of a user's head by tracking as few as six facial feature points. The system locates a human face using a statistical color model and then finds and tracks the facial features, such as eyes, nostrils and lip corners. A full perspective model is employed to map these feature points onto the 3D pose. Several techniques have been developed to track the features points and recover from failure. We currently achieve a frame rate of 15+ frames per second using an HP 9000 workstation with a framegrabber and a Canon VC-C1 camera. The application of the system has been demonstrated by a gaze-driven panorama image viewer. The potential applications of the system include multimodal interfaces, virtual reality and video-teleconferencing.
Nodulation of<i>Lupinus albus</i>by Strains of<i>Ochrobactrum lupini</i>sp. nov (2005)

ABSTRACT The nodulation of legumes has for more than a century been considered an exclusive capacity of a group of microorganisms commonly known as rhizobia and belonging to the α- Proteobacteria . However, in the last 3 years four nonrhizobial species, belonging to α and β subclasses of the Proteobacteria , have been described as legume-nodulating bacteria. In the present study, two fast-growing strains, LUP21 and LUP23, were isolated from nodules of Lupinus honoratus. The phylogenetic analysis based on the 16S and 23S rRNA gene sequences showed that the isolates belong to the genus Ochrobactrum . The strains were able to reinfect Lupinus plants. A plasmid profile analysis showed the presence of three plasmids. The nodD and nifH genes were located on these plasmids, and their sequences were obtained. These sequences showed a close resemblance to the nodD and nifH genes of rhizobial species, suggesting that the nodD and nifH genes carried by strain LUP21 T were acquired by horizontal gene transfer. A polyphasic study including phenotypic, chemotaxonomic, and molecular features of the strains isolated in this study showed that they belong to a new species of the genus Ochrobactrum for which we propose the name Ochrobactrum lupini sp. nov. Strain LUP21 T (LMG 20667 T ) is the type strain.
Bridge-Scour Data Management System user's manual (1996)

The Bridge-Scour Data Management System (BSDMS) supports preparation, compilation, and analysis of bridge-scour data. The BSDMS provides interactive storage, retrieval, selection, editing, and display of bridge-scour data sets. Bridge-scour data sets include more than 200 site and measurement attributes of the channel geometry, flow hydraulics, hydrology, sediment, geomorphic-setting, location, and bridge specifications. This user's manual provides a general overview of the structure and organization of BSDMS data sets and detailed instructions to operate the program. Attributes stored by the BSDMS are described along with an illustration of the input screen where the attribute can be entered or edited. Measured scour depths can be compared with scour depths predicted by selected published equations using the BSDMS. The selected published equations available in the computational portion of the BSDMS are described. This manual is written for BSDMS, version 2.0. The data base will facilitate: (1) developing improved estimators of scour for specific regions or conditions; (2) describing scour processes; and (3) reducing risk from scour at bridges. BSDMS is available in DOS and UNIX versions. The program was written to be portable and, therefore, can be used on multiple computer platforms. Installation procedures depend on the computer platform, and specific installation instructions are distributed with the software. Sample data files and data sets of 384 pier-scour measurements from 56 bridges in 14 States are also distributed with the software.
Proteomic Analysis of Primary Cultures of Human Adipose-derived Stem Cells (2005)

Adipogenesis plays a critical role in energy metabolism and is a contributing factor to the obesity epidemic. This study examined the proteome of primary cultures of human adipose-derived adult stem (ADAS) cells as an in vitro model of adipogenesis. Protein lysates obtained from four individual donors were compared before and after adipocyte differentiation by two-dimensional gel electrophoresis and tandem mass spectroscopy. Over 170 individual protein features in the undifferentiated adipose-derived adult stem cells were identified. Following adipogenesis, over 40 proteins were up-regulated by > or = 2-fold, whereas 13 showed a > or = 3-fold reduction. The majority of the modulated proteins belonged to the following functional categories: cytoskeleton, metabolic, redox, protein degradation, and heat shock protein/chaperones. Additional immunoblot analysis documented the induction of four individual heat shock proteins and confirmed the presence of the heat shock protein 27 phosphoserine 82 isoform, as predicted by the proteomic analysis, as well as the crystallin alpha phosphorylated isoforms. These findings suggest that the heat shock protein family proteome warrants further investigation with respect to the etiology of obesity and type 2 diabetes.
Molecular analysis of hepatitis B virus "a" determinant in asymptomatic and symptomatic Mexican carriers (2007)

Differences in genotype and in mutations in the "a" determinant were found between strains from asymptomatic and symptomatic HBV Mexican carriers.
Assembly of the Hap2p/Hap3p/Hap4p/Hap5p-DNA Complex in <i>Saccharomyces cerevisiae</i> (2005)

The CCAAT-binding factor (CBF) is an evolutionarily conserved multimeric transcriptional activator in eukaryotes. In Saccharomyces cerevisiae, the CCAAT-binding factor is composed of four subunits, termed Hap2p, Hap3p, Hap4p, and Hap5p. The Hap2p/Hap3p/Hap5p heterotrimer is the DNA-binding component of the complex that binds to the consensus 5'-CCAAT-3' sequence in the promoter of target genes. The Hap4p subunit contains the transcriptional activation domain necessary for stimulating transcription after interacting with Hap2p/Hap3p/Hap5p. In this report, we demonstrate that Hap2p, Hap3p, and Hap5p assemble via a one-step pathway requiring all three subunits simultaneously, as opposed to the mammalian CCAAT-binding factor which has been shown to assemble via a two-step pathway with CBF-A (Hap3p homolog) and CBF-C (Hap5p homolog) forming a stable dimer before CBF-B (Hap2p homolog) can interact. We have also found that the interaction of Hap4p with Hap2p/Hap3p/Hap5p requires DNA binding as a prerequisite. To further understand the protein-protein and protein-DNA interactions of this transcription factor, we identified the minimal domain of Hap4p necessary for interaction with the Hap2p/Hap3p/Hap5p-DNA complex, and we demonstrate that this domain is sufficient to complement the respiratory deficiency of a hap4Delta mutant and activate transcription when fused with the VP16 activation domain. These studies provide a further understanding of the assembly of the yeast CCAAT-binding factor at target promoters and raise a number of questions concerning the protein-protein and protein-DNA interactions of this multisubunit transcription factor.
Augmented reality in large environments: Application to aided navigation in urban context (2010)

This paper addresses the challenging issue of vision-based localization in urban context. It briefly describes our contributions in large environments modeling and accurate camera localization. The efficiency of the resulting system is illustrated through Augmented Reality results on large trajectory of several hundred meters.
On the relationship between structure and reaction rate in olefin ring-closing metathesis (2010)

In the RCM reactions of a series of simple α,ω-dienes, the relative order of reactivity has been unambiguously determined showing that cyclohexene forms faster than cyclopentene or cycloheptene. 1,5-Hexadiene inhibits the RCM of 1,7-octadiene; 1,5-hexadiene cannot progress to the RCM product (cyclobutene) but forms an unexpectedly stable cyclic η(2)-complex.
HPLC separation of chlorophyll and carotenoid pigments of four kiwifruit cultivars (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHPLC separation of chlorophyll and carotenoid pigments of four kiwifruit cultivarsM. Pilar CanoCite this: J. Agric. Food Chem. 1991, 39, 10, 1786–1791Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/jf00010a019https://doi.org/10.1021/jf00010a019research-articleACS PublicationsRequest reuse permissionsArticle Views1298Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Low‐Pressure Metal–Organic Chemical Vapor Deposition of Transparent and p‐Type Conducting CuCrO<sub>2</sub> Thin Films with High Conductivity (2003)

The growth of CuCrO 2 films on glass substrate by LP‐MOCVD is reported . Unlike nearly all transparent conducting oxides which exhibit only n‐type conductivity, CuCrO 2 crystalline thin films deposited from Cu(acac) 2 and Cr(acac) 3 precursors exhibit positive Hall co‐efficient with the highest carrier Hall mobility reported to date for any p‐type transparent conducting oxide based on Cu‐delafossite structure. The deposition, performed at 823 K, grows at a rate of 13 nm min –1 . XRD analysis indicates diffraction peaks corresponding to the (101), (012), (104), and (110) planes. The direct optical bandgap is calculated to be 3.08 eV.
Thermus silvanus sp. nov. and Thermus chliarophilus sp. nov., Two New Species Related to Thermus ruber but with Lower Growth Temperatures (1995)

Strains of Thermus silvanus sp. nov. and strains of Thermus chliarophilus sp. nov. were isolated from the hot spring at Vizela in northern Portugal and the hot spring at Alcafache in central Portugal, respectively. The strains of T. silvanus produce orange-red-pigmented colonies and have an optimum growth temperature of about 55 degrees C, while the strains of T. chliarophilus produce yellow-pigmented colonies and have an optimum growth temperature of about 50 degrees C. The strains of both species are catalase negative. These species can be distinguished from each other and from Thermus ruber by biochemical characteristics, fatty acid composition data, and 16S rRNA gene sequence data. Our phylogenetic analysis showed that strains VI-R2T (T = type strain) and ALT-8T belong to the T. ruber line of descent. The type strain of T. silvanus is strain VI-R2 (= DSM 9946), and the type strain of T. chliarophilus is strain ALT-8 (= DSM 9957).
Physiological Responses to Wheelchair and Arm Crank Ergometry in Acute Spinal Cord Individuals (1995)

Shepherd Spinal Center, 2020 Peachtree Rd NW, Atlanta, GA 30309. Funded by the National Institute on Disability and Rehabilitation Research, Shepherd Spinal Center.
New hypothesis of chronic back pain: low <scp>pH</scp> promotes nerve ingrowth into damaged intervertebral disks (2012)

The pathogenesis of low back pain is still elusive. Here, we proposed a new hypothesis that low pH is a possible cause of the development and progression of low back pain. We propose that low pH promotes the production of the inflammatory mediators and the depletion of proteoglycan in the damaged intervertebral disk. The inflammation response, evoked by the dorsal root ganglia, changes the delicate nutrient balance in the nucleus, resulting in a vicious cycle and leading to choronic back pain. Our hypothesis may explain many of the available clinical and experimental data on low back pain, thus it may help elucidate the pathogenesis of low back pain and improve clinical management.
Managing the earth (2002)

Introduction 1. How Fragile is the Earth System? 2. Risks of Conflict: Resource and Population Pressures 3. Valuing the Earth: Reintegrating the Study of Humans and the Rest of Nature 4. Can Technology Save us from Global Climate Change? 5. The Role of Corporate Leadership 6. Who Governs a Sustainable World? The Role of International Courts and Tribunals 7. The Climate Change Regime: Can a Divided World Unite? 8. Protecting the Vulnerable: Climate Change and Food Security
Aerogels and Xerogels of  V 2 O 5 as Intercalation Hosts (1995)

Sol‐gel processing of yields amorphous aerogels (ARG) and xerogels (XRG) that serve as high capacity intercalation hosts for lithium ions. The insertion process is highly reversible in both the aerogel and xerogel form, suggesting that they are attractive for rechargeable lithium batteries and other electrochemical devices.
Fast MRI by creating multiple spin echoes in a CPMG sequence (1993)

A fast multislice imaging technique has been developed. RASTER (Rapid Acquisition with STimulated Echo Refocusing) is based on RARE (Rapid Acquisition with Relaxation Enhancement), and creates multiple spin echoes/each 180 degrees pulse utilizing stimulated echoes, and phase encode each differently. The sequence can be much faster than RARE while keeping the same spin echo image contrast. The main limitation of the technique is reduced signal-to-noise ratio.
γ-Secretase-Dependent Proteolysis of CD44 Promotes Neoplastic Transformation of Rat Fibroblastic Cells (2006)

The metalloprotease-dependent extracellular domain cleavage of the adhesion molecule CD44 is frequently observed in human tumors and is thought to promote metastasis. This cleavage is followed by gamma-secretase-dependent release of CD44 intracellular domain (CD44-ICD), which exhibits nuclear signaling activity. Using a reversible Ret-dependent oncogenic conversion model and a restricted proteomic approach, we identified a positive correlation between the neoplastic transformation of Rat-1 cells and the expression of standard CD44. In these transformed cells, CD44 was found to undergo a sequential metalloprotease and gamma-secretase cleavage, resulting in an increase in expression of CD44-ICD. We showed that this proteolytic fragment possesses a transforming activity. In support of this role, a significant and specific reduction in Ret-induced transformation of Rat-1 cells was observed following drug-mediated inhibition of gamma-secretase. Taken together, these findings suggest that the shedding of CD44 may not only modulate metastasis but also affects earlier events in tumorigenesis through the release of CD44-ICD.
Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids (2017)

Covering: 2000 to 2017Ergot alkaloids are among the most important pharmaceuticals and natural toxins. Significant progress has been achieved in recent years on the research of ergot alkaloids. In this review, we re-introduced the history of ergot alkaloids. Meanwhile, we summarized all the natural products and semi-synthetic derivatives of ergot alkaloids. We also briefly described the biosynthesis and semi-synthesis of ergot alkaloid drugs from raw materials obtained by fermentation. Moreover, we reviewed the advances that have been made in the total synthesis of ergot alkaloids since 2000.