gebhart/patrepeval huggingface dataset:
Fractionation and identification of some low molecular weight grape seed phenolics (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFractionation and identification of some low molecular weight grape seed phenolicsJan Oszmianski and Jean C. SapisCite this: J. Agric. Food Chem. 1989, 37, 5, 1293–1297Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/jf00089a019https://doi.org/10.1021/jf00089a019research-articleACS PublicationsRequest reuse permissionsArticle Views406Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Taxol enhances but does not induce interleukin-1 beta and tumor necrosis factor-alpha production. (1993)

Taxol is a potent, microtubule-stabilizing, antineoplastic drug that induces interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) release by thioglycolate-elicited mouse peritoneal macrophages. Because taxol use and subsequent cytokine release in human subjects could be associated with toxicity, the present study was performed to determine how taxol affects cytokine production from fresh human mononuclear cells. Cells were incubated overnight with varying doses of bacterial endotoxin, either with or without taxol, 10 mumol/L. Taxol alone did not induce IL-1-beta or TNF-alpha release by mononuclear cells. However, at all doses of endotoxin from 1 pg/ml to 1 microgram/ml, the addition of taxol resulted in a 50% to 100% increase in IL-1-beta release (p < 0.001) and a 25% to 50% increase in TNF-alpha release (p < 0.01). In contrast, taxol caused a reduction in intracellular pro-IL-1-beta levels. Kinetic studies demonstrated that taxol enhanced IL-1-beta release by mononuclear cells at all time points tested from 4.5 hours to 18 hours after stimulation. Taxol alone did not stimulate IL-1-beta or TNF-alpha mRNA transcription. A similar enhancement of IL-1-beta release was noted in endotoxin-stimulated alveolar macrophages. In summary, these results show that under endotoxin-free conditions, the microtubule-stabilizing agent taxol does not induce IL-1-beta or TNF-alpha production by human mononuclear cells or alveolar macrophages but does enhance production of both of these cytokines in conjunction with a second stimulus.
Phenylazo-pyridine and Phenylazo-pyrazole Chlorido Ruthenium(II) Arene Complexes:  Arene Loss, Aquation, and Cancer Cell Cytotoxicity (2006)

Ru(II) eta6-arene complexes containing p-cymene (p-cym), tetrahydronaphthalene (thn), benzene (bz), or biphenyl (bip), as the arene, phenylazopyridine derivatives (C5H4NN:NC6H5R; R = H (azpy), OH (azpy-OH), NMe2 (azpy-NMe2)) or a phenylazopyrazole derivative (NHC3H2NN:NC6H5NMe2 (azpyz-NMe2)) as N,N-chelating ligands and chloride as a ligand have been synthesized (1-16). The complexes are all intensely colored due to metal-to-ligand charge-transfer Ru 4d6-pi* and intraligand pi -->pi* transitions (eta = 5000-63 700 M-1 cm-1) occurring in the visible region. In the crystal structures of [(eta6-p-cym)Ru(azpy)Cl]PF6 (1), [(eta6-p-cym)Ru(azpy-NMe2)Cl]PF6 (5), and [(eta6-bip)Ru(azpy)Cl]PF6 (4), the relatively long Ru-N(azo) and Ru-(arene-centroid) distances suggest that phenylazopyridine and arene ligands can act as competitive pi-acceptors toward Ru(II) 4d6 electrons. The pKa* values of the pyridine nitrogens of the ligands are low (azpy 2.47, azpy-OH 3.06 and azpy-NMe2 4.60), suggesting that they are weak sigma-donors. This, together with their pi-acceptor behavior, serves to increase the positive charge on ruthenium, and together with the pi-acidic eta6-arene, partially accounts for the slow decomposition of the complexes via hydrolysis and/or arene loss (t(1/2) = 9-21 h for azopyridine complexes, 310 K). The pKa* of the coordinated water in [(eta6-p-cym)Ru(azpyz-NMe2)OH2]2+ (13A) is 4.60, consistent with the increased acidity of the ruthenium center upon coordination to the azo ligand. None of the azpy complexes were cytotoxic toward A2780 human ovarian or A549 human lung cancer cells, but several of the azpy-NMe2, azpy-OH, and azpyz-NMe2 complexes were active (IC50 values 18-88 microM).
The Application of Correlation Techniques to Some Acoustic Measurements (1955)

This paper discusses the application of an analog correlator which computes the crosscorrelation function between two sound pressures to such measurement problems as the localization of noise sources, the determination of transmission loss, and the reduction of microphone wind noise. The crosscorrelation function φ21 (r) between two nonperiodic signals will have a peak in amplitude if a component of each signal originates from a common source. The value of time delay τ for which this peak occurs equals the difference in time required for the individual components to propagate from the common source to the two points under study. An analog electronic correlator described in a companion paper has been constructed which, by employing this property of the crosscorrelation function, can separate the acoustic signal at a given point into components according to: (1) their points of origin (assuming independent sources), (2) the transit time from source to the point in question, and (3) frequency. Preliminary experimental results show that correlation provides a practical method for determining the amount of sound contributed to the field at a given point by each of several sources. The correlator, by separating the signal transmitted directly through the structure from the flanking signal on the basis of arrival time, is also a useful tool for measuring the transmission loss of walls.
Ink-jet Printing of Nano Materials and Processes for Electronics Applications (2007)

Ag metallic particles from nano-scale to submicron-scale are combined with organic solvent to provide fine circuits and interconnection. Ag nanoparticle pastes have been successfully adopted to ink-jet wiring and the multilayered circuit layers in a SiP structure. Ink-jet printing with Ag nano particle pastes demonstrated the potentials of the new printed electronics technology. Lowering process temperature for Ag nanoparticle pastes finally reached room temperature wiring in air atmosphere.
Higher-Order Modes in Dielectrically Loaded Rectangular Waveguides (1968)

The problem of propagation in a waveguide containing E-plane slabs of dielectric was considered previously by several authors. However, their treatment was limited to the TE/sub mo/ modes. A more general and complete derivation of the dispersion equations for all the modes existing in these structures is presented here. It is shown, on the basis of theoretical and experimental results, that the frequency bandwidth is much smaller than the values previously obtained, considering only the TE/sub mo/ modes, for many cases of practical interest
ChemInform Abstract: NEW REAGENTS. 13. BINDING OF PROVEN DONOR GROUPS OF ORGANO‐TRANSITION METAL CHEMISTRY TO MULTIELECTRON LIGANDS (1980)

Abstract Die Umsetzung des leicht zugänglichen Spirokohlenwasserstoffs (II) mit Organolithium‐ bzw. ‐dilithiumverbindungen und anschließende Zugabe von Wasser führen zu den thermolabilen Verbindungen (I) bzw. (III) als Isomerengemischen, die durch NMR‐, IR‐ und MS‐Spektren charakterisiert wurden.
Occurrence of Cancer in Alzheimer and Elderly Control Patients (1994)

Epidemiologic necropsy provides an accurate measure of the occurrence rates of diseases. To determine the occurrence of cancer in Alzheimer patients as well as in non-Alzheimer elderly controls, we examined autopsy reports of 575 control and 71 Alzheimer cases aged 50-100 years for histologic evidence of cancer. We compared expected rates of cancers calculated from the National Cancer Institute's Surveillance, Epidemiology and End Result (SEER) Program data to rates observed at autopsy using a chi-squared test. To determine whether there was an association between the occurrence of cancer and Alzheimer disease, we compared rates for all cancer and three specific cancers in Alzheimer and control patients using an odds ratio test. We found from fourfold to 98-fold more cancer in Alzheimer patients and controls than that expected from SEER data. There was no statistical difference in the autopsy incidence of total, lung, or prostate cancer between Alzheimer patients and controls. However, the occurrence of pancreatic cancer was 6.7-fold higher in Alzheimer patients than in control subjects. Controlling for multiple comparisons, the odds ratio for pancreatic cancer in Alzheimer's disease was significantly higher than in controls (p < 0.001). Our results indicate that cancer occurs more frequently than expected in both Alzheimer patients and control subjects. In addition, there may be an association between the occurrence of certain cancers and Alzheimer's disease.
Prognostic molecular biomarkers for cutaneous malignant melanoma (2011)

Molecular signatures of melanoma have propelled new approaches to early diagnosis, monitoring of treatment response, and targeted therapy. This review discusses messenger RNA (mRNA), genomic, and epigenomic melanoma biomarkers in blood and tissue specimens. The major focus is on tissue-based molecular assays to upstage sentinel lymph nodes (SLNs), and blood-based assays to detect melanoma progression by monitoring levels of circulating tumor cells (CTC) and circulating DNA.
Functional decomposition in a vehicle control system (2002)

The introduction of electronic controls in vehicles has lead to ever increasing improvements in automotive performance in the areas of drivability, fuel economy, emissions, and safety. As new technologies emerge and are introduced on vehicles, the need for more sophisticated control solutions to coordinated the new technologies increases. The level of complexity on today's vehicles is at a point where vehicle system level hierarchical controls are required to manage the interaction of the various complex subsystems. A method for determining the allocation of the control functions within the hierarchy is presented and demonstrated for an integrated starter-generator hybrid electric vehicle. An effort is also made to maintain generic definitions of the functional interfaces within the hierarchy in order to facility reusability of the architecture with future vehicle technologies.
Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. (1992)

Glucocorticoids block the induced secretion of prostaglandins in a variety of biological contexts. We have identified a primary response gene, TIS10, which encodes a mitogen-inducible prostaglandin synthase/cyclooxygenase in Swiss 3T3 cells. TIS10 is distinct from prostaglandin synthase/cyclooxygenase. (EC 1.14.99.1), previously cloned from mouse, man, and sheep. Dexamethasone blocks prostaglandin E2 synthesis by 3T3 cells in response to tetradecanoylphorbol acetate. Dexamethasone also blocks both phorbol ester- and forskolin-induced TIS10 mRNA accumulation. In contrast, phorbol esters, forskolin, and dexamethasone have little or no effect on the levels of prostaglandin synthase/cyclooxygenase mRNA in 3T3 cells. Moreover, dexamethasone does not inhibit induction of TIS8/egr-1, another primary response gene. Inhibition of the synthesis of TIS10 prostaglandin synthase/cyclooxygenase may be a principal mechanism by which glucocorticoids block prostaglandin synthesis and secretion.
Characterization of the <i>ccpA</i> Gene of <i>Enterococcus faecalis</i> : Identification of Starvation-Inducible Proteins Regulated by CcpA (2000)

Inactivation of ccpA in Enterococcus faecalis leads to reduction of the growth rate, derepression of the galKETR operon in the presence of a mixture of glucose and galactose, and reduction of transcription of ldh in the presence of glucose. Moreover, the E. faecalis ccpA gene fully complements a Bacillus subtilis ccpA mutant, arguing for similar functions of these two homologous proteins. Protein comparison on two-dimensional gels from the wild-type cells and the ccpA mutant cells revealed a pleiotropic effect of the mutation on gene expression. The HPr protein of the carbohydrate-phosphotransferase system was identified by microsequencing, and a modification of its phosphorylation state was observed between the wild-type and the mutant strains. Moreover, at least 16 polypeptides are overexpressed in the mutant, and 6 are repressed. Interestingly, 13 of the 16 polypeptides whose synthesis is enhanced in the mutant were also identified as glucose starvation proteins. The N-terminal amino acid sequences of four of them match sequences deduced from genes coding for L-serine dehydratase, dihydroxyacetone kinase (two genes), and a protein of unknown function from Deinococcus radiodurans.
Skyrmion-Based Dynamic Magnonic Crystal (2015)

A linear array of periodically spaced and individually controllable skyrmions is introduced as a magnonic crystal. It is numerically demonstrated that skyrmion nucleation and annihilation can be accurately controlled by a nanosecond spin polarized current pulse through a nanocontact. Arranged in a periodic array, such nanocontacts allow the creation of a skyrmion lattice that causes a periodic modulation of the waveguide's magnetization, which can be dynamically controlled by changing either the strength of an applied external magnetic field or the density of the injected spin current through the nanocontacts. The skyrmion diameter is highly dependent on both the applied field and the injected current. This implies tunability of the lowest band gap as the skyrmion diameter directly affects the strength of the pinning potential. The calculated magnonic spectra thus exhibit tunable allowed frequency bands and forbidden frequency bandgaps analogous to that of conventional magnonic crystals where, in contrast, the periodicity is structurally induced and static. In the dynamic magnetic crystal studied here, it is possible to dynamically turn on and off the artificial periodic structure, which allows switching between full rejection and full transmission of spin waves in the waveguide. These findings should stimulate further research activities on multiple functionalities offered by magnonic crystals based on periodic skyrmion lattices.
Capacitance methods in head-disk interface studies (1993)

Three new applications for precise capacitance measurements between sliders and disks are discussed. The slider-disk capacitance is shown to be a nondestructive measurement of stiction forces. The capacitance-stripe technique is discussed as a way to measure fly-height, pitch, and crown of sliders. A new implementation of the capacitance microscope is introduced which uses a special slider to profile a hard disk spinning at up to 20 m/s with 20- mu m lateral resolution and 1-nm vertical resolution. Emphasis is placed on the capacitance microscope, whose chief advantage over conventional profilometry is that it allows continuous observation of a disk under a flying interface in situ. Results from a reliability test are presented to illustrate application of the capacitance microscope. Correlation between magnetic signal loss and physical damage that occurs during this reliability test provides further insight into disk failure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Coordination of Multiple Autonomous Systems using Information Theoretic Political Science Voting Models (2006)

In this paper we introduce an approach to solving a coordination problem involving multiple heterogenous autonomous systems operating in a multi-objective mission domain. The distributed coordination mechanism presented applies an information theoretic political science voting model to the dynamic weighted aggregation method, thereby allowing the decision makers (the autonomous systems), to influence the weights assigned to each mission objective. Results from a simulated instantiation of a multiple objective mission are presented, demonstrating the use of the voting mechanism to coordinate actions undertaken by the autonomous systems. The results show a level of overall mission success comparable to that obtained in an 'ideal' centralised mechanism.
Building an Infrastructure for Law Enforcement Information Sharing and Collaboration: Design Issues and Challenges (2001)

The rapid advancement of information technologies and the Internet provides great opportunities as well as challenges for government agencies. On one hand, these technologies allow better use and sharing of information. With the growing popularity of the Web, information can be shared among agencies or made accessible to the public more easily than ever. On the other hand,
Color-selective semiconductor nanocrystal laser (2002)

Theoretical predictions of the benefits of three-dimensional quantum confinement have provided motivation for the development of quantum-dot lasers. Such lasers, developed in the case of self-assembled quantum dots, have not been successfully demonstrated with quantum-confined colloidal nanocrystals (NCs). Here, using recently developed NC-titania chemistry, we report the successful development of an optically pumped, NC-based distributed feedback laser, in which the narrow gain profiles of these nanoparticles have been matched with the feedback of a second-order distributed feedback laser. This laser, whose output color can be selected by choosing appropriately sized nanocrystals, operates at 80 K and at room temperature.
TTL-CMOS input buffers with no static power dissipation (1996)

Two new implementations of CMOS input buffers that handle TTL level voltages with almost negligible static power dissipation are presented. These buffers reduce the output rising transition time by nearly 25% over existing buffer designs. The power dissipated during signal transitions is comparable or smaller under normal loading conditions.
Low polarization pacing lead for detecting the ventricular-evoked response. (1993)

The cardiac response to a pacing pulse is potentially useful for rate adaptive pacemakers and threshold tracking systems. However, until now capture recognition of the ventricular-evoked response by the use of a single electrode for stimulation as well as detection was limited by the electrode polarization. Electronic measures against the stimulus polarization artifact have not been successful due to the variability of the after potential or the requirement of additional battery power. Following the idea of Lewin, Myers and Parsonnet, who introduced the idea of a non-polarizable porous electrode for physiological stimulation, titanium nitride (TiN) and iridium (Ir) coatings with fractal surface structure have been developed with high electro-chemical active surface areas and Helmholtz double-layer capacities of up to 50,000 microF/cm2, thus reducing the polarization artifact significantly. Two types of endocardial leads (10 with a fractal TiN coating and 5 with a fractal Ir coating) were implanted in the apex of the right ventricle and the polarization artifact, as well as the evoked response, was measured. Both types of pacing leads show a 90% reduction in the polarization artifact in comparison to conventional leads. If an autoshort of approximately 20 to 50 ms is applied after the pacing pulse, the polarization artifact of these leads is negligible, thus enabling reliable detection of at least the repolarization phase of the ventricular-evoked response, which is fully sufficient for capture recognition. Additionally, due to their low polarization losses, TiN- or Ir-coated electrodes with fractal surface structure have a unique stimulation and detection performance.
Guidelines for simulation project success (1993)

Project success comes with improving system performance. Sound project management methods help to guarantee this success. The management guidelines provided in this paper aid in directing the simulation process, controlling model development and analysis, and improving customer relations.
Actin polymerization. The mechanism of action of cytochalasin D. (1986)

Fluorescence changes using actin covalently labeled with N-(1-pyrenyl)iodoacetamide have been used to determine the effect of cytochalasin D on actin polymerization. A mechanism for the effect of cytochalasin D on actin polymerization is presented, which explains the experimental observation of a cytochalasin D-induced increase in the initial rate of polymerization and a decrease in the final extent of the reaction. Central to this mechanism is the Mg2+-dependent formation of cytochalasin D-induced dimers. The dimers serve as nuclei to enhance the polymerization rate. Binding of Mg2+ to a low affinity site on the dimer induces a conformational change which can be observed as a rapid fluorescence increase. A subsequent time-dependent fluorescence decrease observed prior to polymerization appears to represent ATP hydrolysis resulting in dissociation of the dimer and release of actin monomers containing ADP. We postulate that a slow rate of exchange of ATP for bound ADP relative to hydrolysis results in the accumulation of monomers containing ADP. As these monomers have a high critical concentration, the final extent of polymerization is reduced dramatically. The Mg2+ dependence of the final extent of polymerization in the presence of cytochalasin D is also explained in the context of this mechanism.
Direct Design Formulas for Asymmetric Bandpass Channel Diplexers (1977)

This paper gives direct design formulas for asymmetric bandpass channel diplexers, which allow rapid design of diplexers using narrow-band direct-coupled resonator filters. Computed results for a prototype diplexer are given, and results are presented for a 5.8-GHz asymmetric waveguide diplexer, which demonstrate the high performance possible using this design technique.