gebhart/patrepeval huggingface dataset:
Heterogeneity of Nuclear Estrogen-Binding Sites in the Rat Uterus: A Simple Method for the Quantitation of Type I and Type II Sites by [<sup>3</sup>H]Estradiol Exchange* (1981)

Estrogen administration to mature-ovariectomized rats causes the activation or stimulation of secondary nuclear estrogen-binding sites (type II) in the uterus which can interfere with estrogen receptor (type I) measurement. Earlier reports from our laboratory have shown that quantitation of type I sites in the presence of the type II site is very difficult and can only be achieved by graphic analysis of saturation curves which employ a wide range (0.4-40 NM) of [3H]estradiol concentrations in nuclear exchange assay. The studies presented in this manuscript describe simple methods which can be used to separately quantitate both nuclear estrogen-binding sites using a single concentration of [3H]estradiol. Since the nuclear type II site does not bind [3H]estradiol in the presence of reducing agent, type I sites can be easily quantitated by incubating nuclei (37 C for 30 min) in Tris-EDTA buffer containing 0.1-1.00 mM dithiothreitol using a single saturating concentration of [3H]estradiol. Conversely, a single concentration of [3H]estradiol (40-80 nM) can be used to quantitate the nuclear type II site by incubating nuclei in Tris-EDTA buffer under conditions (4 C for 60 min) which do not measure occupied nuclear estrogen receptor. Therefore, by using the appropriate buffer system, type I and type II sites can be easily separated in mixed binding systems. In addition, we also demonstrate that Nafoxidine does not bind to the nuclear type II site. Therefore, it can be used as a competitive inhibitor of [3H]estradiol binding to type I sites and permit the measurement of type II sites without interference from type I sites. These techniques should be applicable to autoradiographic or fluorescence studies which cannot discriminate between steroid binding to these two classes of nuclear estrogen-binding sites.
Characterization of a complex near-surface structure using well logging and passive seismic measurements (2016)

Abstract. We combine geophysical well logging and passive seismic measurements to characterize the near-surface geology of an area located in Hontomin, Burgos (Spain). This area has some near-surface challenges for a geophysical study. The irregular topography is characterized by limestone outcrops and unconsolidated sediments areas. Additionally, the near-surface geology includes an upper layer of pure limestones overlying marly limestones and marls (Upper Cretaceous). These materials lie on top of Low Cretaceous siliciclastic sediments (sandstones, clays, gravels). In any case, a layer with reduced velocity is expected. The geophysical data sets used in this study include sonic and gamma-ray logs at two boreholes and passive seismic measurements: three arrays and 224 seismic stations for applying the horizontal-to-vertical amplitude spectra ratio method (H/V). Well-logging data define two significant changes in the P-wave-velocity log within the Upper Cretaceous layer and one more at the Upper to Lower Cretaceous contact. This technique has also been used for refining the geological interpretation. The passive seismic measurements provide a map of sediment thickness with a maximum of around 40 m and shear-wave velocity profiles from the array technique. A comparison between seismic velocity coming from well logging and array measurements defines the resolution limits of the passive seismic techniques and helps it to be interpreted. This study shows how these low-cost techniques can provide useful information about near-surface complexity that could be used for designing a geophysical field survey or for seismic processing steps such as statics or imaging.
Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes (1998)

Reactive oxygen species (ROS) have been proposed to participate in the induction of cardiac preconditioning. However, their source and mechanism of induction are unclear. We tested whether brief hypoxia induces preconditioning by augmenting mitochondrial generation of ROS in chick cardiomyocytes. Cells were preconditioned with 10 min of hypoxia, followed by 1 h of simulated ischemia and 3 h of reperfusion. Preconditioning decreased cell death from 47 +/- 3% to 14 +/- 2%. Return of contraction was observed in 3/3 preconditioned versus 0/6 non-preconditioned experiments. During induction, ROS oxidation of the probe dichlorofluorescin (sensitive to H2O2) increased approximately 2.5-fold. As a substitute for hypoxia, the addition of H2O2 (15 micromol/liter) during normoxia also induced preconditioning-like protection. Conversely, the ROS signal during hypoxia was attenuated with the thiol reductant 2-mercaptopropionyl glycine, the cytosolic Cu,Zn-superoxide dismutase inhibitor diethyldithiocarbamic acid, and the anion channel inhibitor 4,4'-diisothiocyanato-stilbene-2,2'-disulfonate, all of which also abrogated protection. ROS generation during hypoxia was attenuated by myxothiazol, but not by diphenyleneiodonium or the nitric-oxide synthase inhibitor L-nitroarginine. We conclude that hypoxia increases mitochondrial superoxide generation which initiates preconditioning protection. Furthermore, mitochondrial anion channels and cytosolic dismutation to H2O2 may be important steps for oxidant induction of hypoxic preconditioning.
Physically-based interactive bi-scale material design (2011)

We present the first physically-based interactive system to facilitate the appearance design at different scales consistently, through manipulations of both small-scale geometry and materials. The core of our system is a novel reflectance filtering algorithm, which rapidly computes the large-scale appearance from small-scale details, by exploiting the low-rank structures of the Bidirectional Visible Normal Distribution Function and pre-rotated BRDFs in the matrix formulation of our rendering problem. Our algorithm is three orders of magnitude faster than a ground-truth method. We demonstrate various editing results of different small-scale geometry with analytical and measured BRDFs. In addition, we show the applications of our system to physical realization of appearance, as well as modeling of real-world materials using very sparse measurements.
A class hierarchy emulating virtual shared objects on message-passing systems (2002)

Multicomputer systems are increasingly becoming of primary interest for scalable performance. Due to their distributed memory they require use of the message-passing paradigm which, however, is considered as low level programming. Remote access facilities and reliable emulation of shared memory can hide message-passing behind a more abstract interaction protocol. In this paper we address parallel programming and investigate the special requirements to be met by shared objects. We present a class hierarchy which serves as a programming environment for highly parallel, scalable computers. The class hierarchy provides base classes for communication facilities along with a global object name space. We introduce composite virtual objects as object-oriented abstractions implemented as a group of elementary, objects. Base classes for shared composite virtual objects emulating fundamental and derived data types in C++ have been implemented. Examples show how run-time efficient the introduced approach is and how it impacts the code in terms of programming style.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
IMPATT-Diode Multistage Transmission Amplifiers (1970)

In this paper are described the analytical design and experimental performance of broad-band IMPATT-diode transmission amplifiers. These amplifiers are negative-resistance loaded waveguide bandpass filters which do not employ interstage isolation. Computer-aided-design techniques for single- and multiple-stage amplifiers are described in detail along with performance of simplifiers based on these designs. Typical performance at X-band includes large-signal gains of 5-10 dB, output power of 1 watt or greater, and bandwidths of up to 10 percent. These characteristics are in good agreement with the design values.
Communication-efficient anonymous group identification (1998)

Article Free Access Share on Communication-efficient anonymous group identification Authors: Afredo De Santis Dipartimento di Informatica ed Appliczioni, Università di Salerno, 84081 Baronissi (SA), Italy Dipartimento di Informatica ed Appliczioni, Università di Salerno, 84081 Baronissi (SA), ItalyView Profile , Giovanni Di Crescenzo Computer Science and Engineering Department, University of California San Diego, La Jolla, CA Computer Science and Engineering Department, University of California San Diego, La Jolla, CAView Profile , Giuseppe Persiano Dipartimento di Informatica ed Appliczioni, Università di Salerno, 84081 Baronissi (SA), Italy Dipartimento di Informatica ed Appliczioni, Università di Salerno, 84081 Baronissi (SA), ItalyView Profile Authors Info & Claims CCS '98: Proceedings of the 5th ACM conference on Computer and communications securityNovember 1998 Pages 73–82https://doi.org/10.1145/288090.288110Published:01 November 1998Publication History 23citation593DownloadsMetricsTotal Citations23Total Downloads593Last 12 Months16Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Cytokine levels in seminal plasma. (1998)

We have studied IL-2, SIL-2R, and sCD4 concentrations in the seminal plasma of 20 healthy men (controls), 20 oligozoospermics and 20 azoospermics by the "sandwich" enzyme immunoassay technique. We have also measured IL-2, SIL-2R and sCD4 in the two fractions of the split ejaculate of 10 healthy men. Our results show that the mean IL-2 and sCD4 concentrations in the seminal plasma were significantly higher compared to the levels in the serum of normal men; furthermore, there were no significant differences of SIL-2R and sCD4 between the group of normal men and the groups of men with oligozoospermia or azoospermia. On the contrary, significantly higher levels of IL-2 and sCD4 were found in the first compared to the second fraction of the split ejaculates. Our results support the view that the estimation of IL-2 in seminal plasma has value concerning the quality of semen. On the contrary, the estimation of SIL-2R and sCD4 in seminal plasma are valueless concerning normal or abnormal semen. Finally, the prostate seems to be the main site or origin of IL-2 and sCD4.
Consensus Network Decoding for Statistical Machine Translation System Combination (2007)

This paper presents a simple and robust consensus decoding approach for combining multiple machine translation (MT) system outputs. A consensus network is constructed from an N-best list by aligning the hypotheses against an alignment reference, where the alignment is based on minimising the translation edit rate (TER). The minimum Bayes risk (MBR) decoding technique is investigated for the selection of an appropriate alignment reference. Several alternative decoding strategies proposed to retain coherent phrases in the original translations. Experimental results are presented primarily based on three-way combination of Chinese-English translation outputs, and also presents results for six-way system combination. It is shown that worthwhile improvements in translation performance can be obtained using the methods discussed.
Imaging techniques with refractive beam shaping optics (2012)

Applying of the refractive beam shapers in real research optical setups as well as in industrial installations requires very often manipulation of a final laser spot size. In many cases this task can be easily solved by using various imaging optical layouts presuming creating an image of a beam shaper output aperture. Due to the unique features of the refractive beam shapers of field mapping type, like flat wave front and low divergence of the collimated resulting beam with flattop or another intensity profile, there is a freedom in building of various imaging systems with using ordinary optical components, including off-the-shelf ones. There will be considered optical layouts providing high, up to 1/200×, de-magnifying factors, combining of refractive beam shapers like πShaper with scanning systems, building of relay imaging systems with extended depth of field. These optical layouts are widely used in such laser technologies like drilling holes in PCB, welding, various micromachining techniques with galvo-mirror scanning, interferometry and holography, various SLM-based applications. Examples of real implementations and experimental results will be presented as well.
Ultra-Compact and Low-Loss Silica-Based Dual Polarization Optical Hybrid for Digital Coherent Receiver with Excellent Common-Mode Rejection Ratio (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Mizuno, T. Saida, Y. Nasu, T. Yamada, Y. Hashizume, and H. Takahashi, "Ultra-Compact and Low-Loss Silica-Based Dual Polarization Optical Hybrid for Digital Coherent Receiver with Excellent Common-Mode Rejection Ratio," in Optical Fiber Communication Conference/National Fiber Optic Engineers Conference 2013, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper OTh3H.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Get Video Citation alert Save article
Composite Applications in Highway Bridges (1990)

This report presents a summary of a four year research effort titled, 'Transfer of Composite Technology to Design and Construction of Bridges'. Extensive analytical and experimental research was performed on fiber reinforced plastic cables and bridge decks. A description of those structural elements is presented.
Digital determination of third-octave and full-octave spectra of acoustical noise (1967)

The spectrum of the acoustical noise produced by typical sources such as business machines is usually measured with analog filter banks. The objective of this study was to perform spectral analysis using digital rather than analog methods. The Cooley-Tukey algorithm has been used to compute the Fourier coefficients of noise samples obtained with the aid of a digital recording system described previously [4]. The resulting coefficients have been used to compute octave band and third-octave band spectra of the noise samples. The digital spectral estimates are in good agreement with analog measurements. Emphasis is placed on the filter characteristic or "window" used for the analysis, and the spectral fluctuations which occur in short (65-250 ms) samples of the noise. For one machine studied, the spectral fluctuations are larger than would be expected for samples of random noise. Spectral analysis of impulsive noise produced by a second machine (a manual, key-entry card punch) indicates that spectral fluctuations occur even when the envelope of the pressure-time pattern is observed to be repetitive.
Object-based stereo matching using adjustable-cross for depth estimation (2015)

In this paper, an algorithm of object-based stereo matching using adjustable-cross is proposed for depth estimation. The algorithm can generate the depth map of the target objects in the image. It is composed of three steps: Pre-processing, Matching Cost Aggregation and Refinement. In Pre-processing, the Edge Detection is used to remove redundant background information and retain shapes of objects. To improve the shapes of objects, the Object Extension is further applied. Then, the holes generated by previous processing are removed by the Hollow Filling. In Matching Cost Aggregation step, the proposed adaptive window whose size is computed by extracted region of object is used for the Stereo Matching. Moreover, the disparity map is computed and transformed to depth map by the Stereo Matching. Finally, the generated depth map is refined by median filter in the Refinement. The experimental results show that the proposed algorithm can reduce the computational complexity about 91%.
New Straightforward Route to an Huperzine a Synthetic Intermediate (1997)

Abstract A five steps sequence of reactions afforded in high yield the tetrahydroquinoline derivative 3, a key intermediate in Huperzine A synthesis.
Fuel Cell Systems-II (1969)

Double skeleton catalyst (DSK) electrodes combine the high catalytic activity of Raney powder catalysts with the mechanical rigidity and electrical conductivity of bulk metals. They consist of a supporting macroskeleton pressed and sintered of metal grains of uniform size and Raney catalyst grains embedded in its pores. The physical, chemical, and electrocatalytic properties of such DSK anodes are reported. Roth resistance for electrolyte flow and electric resistance of the porous electrode increase steeply at a potential of +150 mv. vs. reversible hydrogen electrode in the same electrolyte and this effect is explained by filling up the pores with nickel hydroxide. A thorough investigation of the anodically formed oxide layers has shown that here exists beside the easily reducible Ni(OH)2 a scarcely reducible "aged" form.
The Effect of Infection with Different Strains of Newcastle Disease Virus on Cellular RNA and Protein Synthesis (1972)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Characteristics of Human Sperm Chromatin Structure Following an Episode of Influenza and High Fever: A Case Study (2000)

Semen samples from a fertile patient presenting with influenza and a 1-day fever of 39.9 degrees C were obtained and analyzed at 18-66 days postfever (dpf) for sperm nuclear proteins, DNA stainability, free thiols (-SH), and susceptibility to DNA denaturation in situ. At 18 dpf, 36% of sperm demonstrated denatured DNA as measured by the sperm chromatin structure assay (SCSA), and decreased to 23% by 39 dpf. Samples at 33 and 39 dpf contained 49% and 30%, respectively, of cells with increased DNA stainability (HIGRN). A unique sperm nuclear protein band migrating between histones and protamines on acid-urea gels appeared at 33 and 39 dpf and nearly disappeared by 52 dpf. Amino acid sequencing of the first 8 N-terminal residues identified this protein as the precursor to protamine 2. The protamine P1 and P2 ratio remained normal, whereas the histone to protamine ratio increased slightly at 33 to 39 dpf. Flow cytometric measurements of nuclear -SH groups revealed the greatest reduction in free nuclear thiols at 33 dpf, and returned to normal by 45 dpf. The time of appearance of the unprocessed protamine 2 precursor and the relative increase in histone suggest a fever-related disruption of the synthesis of mRNA that codes for a P2 processing enzyme or enzymes. Increased DNA staining is likely due to the increased histone/protamine ratio. This case study demonstrates that fever/influenza can have latent effects on sperm chromatin structure and may result in transient release of abnormal sperm.
Picosecond Single-Photon and Femtosecond Two-Photon Pulsed Laser Stimulation for IC Characterization and Failure Analysis (2009)

Abstract This paper presents the use of pulsed laser stimulation with picosecond and femtosecond laser pulses. We first discuss the resolution improvement that can be expected when using ultrashort laser pulses. Two case studies are then presented to illustrate the possibilities of the pulsed laser photoelectric stimulation in picosecond single-photon and femtosecond two-photon modes.
Structural Polymer Composites for Energy Storage Devices (2011)

Multifunctional composites have attracted a great deal of attention as they offer a way to cut down the parasitic weight in vehicles which not only reduces the operational costs but also reduces the fuel consumption in vehicles. Current engineering design is increasingly sophisticated, requiring more efficient material utilisation; sub-system mass and volume are crucial application determinants. This dissertation contributes to the fabrication of composites that can store electrical energy and are known as structural supercapacitors. The key in the fabrication of structural supercapacitors was not simply to bind two disparate components together, but to produce a single coherent material that inherently performed both roles of a structural composite and a supercapacitor. This design approach is at a relatively early stage, and faces significant design and material synthesis challenges. Disparate material requirements, such as structural and electrochemical properties, have to be engineered and optimised simultaneously. This study investigates on structural supercapacitors fabricated by using as-received as well as activated carbon fibre cloths as reinforcement and electrodes; multifunctional resin as electrolyte and matrix; and glass fibre cloths, filter papers or polymer membranes as insulators. Such a system should deliver electrical energy storage capacity as well as bear mechanical loads. Different liquid electrolytes, such as ionic liquids and salts based on Li+ and NH4+, were studied in order to optimise the multifunctionality of polymer electrolyte. Mesoporous silica particles were also introduced into polymer electrolytes in order to enhance the mechanical and electrochemical performance of polymer electrolytes. Nanostructured/ multifunctional resin blends were cured in cylindrical form and were examined by compression testing as well as impedance spectroscopy. An ionic conductivity of 0.8 mS/cm and a compression modulus of 62 MPa have been synthesised for the polymer electrolyte in the current study. By varying the separators, multifunctional resins and the electrodes, different structural supercapacitor configurations were manufactured using a resin infusion under flexible tooling (RIFT) method and were characterised to study the electrochemical performance by using charge/discharge method and mechanical performance by using ±45° laminate shear testing. The improved structural supercapacitors showed an energy density of 0.1 Wh/kg, a power density of 36 W/kg and a shear modulus of 1.7 GPa.
Carbon—Silica Dual Phase Filler, a new Generation Reinforcing Agent for Rubber: Part IX. Application to Truck Tire Tread Compound (2001)

Abstract The application of carbon-silica dual phase fillers (CSDPF) to natural rubber compound was investigated. It was found that these new fillers give significantly better overall performances in comparison with the conventional fillers—carbon black and silica. In a typical truck-tread compound, due to its high polymer—filler interaction and lower filler—filler interaction, the CSDPF E shows a comparable laboratory abrasion resistance and more than 40% reduction in tan δ at 70 °C, a parameter for rolling resistance, compared to compound filled with its carbon black counterpart, N1 10. These properties can, to a certain degree, be further improved by the addition of a small amount of coupling agent, bis(3-triethoxysilylpropyl)tetrasulfane (TESPT). In the case of wet skid resistance measured using the British Portable Skid Tester, the data show that CSDPF gives better performance than the conventional fillers, with and without coupling agent.