New Macrolide Antibiotics: Azithromycin and Clarithromycin (1992)

Editorials15 March 1992New Macrolide Antibiotics: Azithromycin and ClarithromycinHarold C. Neu, MDHarold C. Neu, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-517 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEythromycin, the prototype of the macrolide antibiotics, was first used to treat infections in 1952. It has been used to treat streptococcal pharyngitis in penicillin-allergic patients,Mycoplasma pneumoniaerespiratory infections, Legionella infection, and cutaneous infections due to streptococci and staphylococci (1). Erythromycin has also been used to treat pneumococcal infection of the ears, sinuses, and chest. It has also been used as prophylaxis during dental procedures in patients with valvular heart disease to prevent endocarditis and as prophylaxis before colonic surgery to prevent postoperative infection. Except for hepatic toxicity with the estolate form and rare temporary deafness at high doses,...References1. WashingtonWilson JW. Erythromycin, a microbiological and clinical perspective after 30 years of clinical use. Mayo Clin Proc. 1985;60:189-203. CrossrefMedlineGoogle Scholar2. KirstSides HG. New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy. Antimicrob Agents Chemother. 1989;33:1419-22. CrossrefMedlineGoogle Scholar3. Neu H. Clinical microbiology of azithromycin. Am J Med. 1991;91(Suppl 3A):12-8. CrossrefGoogle Scholar4. Neu H. The development of macrolides: clarithromycin in perspective. J Antimicrob Chemother. 1991;27(Suppl A): 1-9. CrossrefMedlineGoogle Scholar5. BrownWallaceOnyiDeRosasWallace BRGVR. Activities of four macrolides including clarithromycin against Mycobacterium fortuitum, M. chelonei and M. chelonei-like organisms. Antimicrob Agents Chemother. 1992;36:180-4. CrossrefMedlineGoogle Scholar6. AraujoGuptillRemington FDS. 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Author, Article, and Disclosure InformationAffiliations: Columbia University New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Cardiovascular Effects of Treatment with Hydroxychloroquine and AzithromycinANTIMICROBIAL THERAPY IN THE ELDERLYCommonly Used Antibacterial and Antifungal Agents for Hospitalised Paediatric PatientsNEWER MACROLIDESAntibiotic use in the emergency department. II. The aminoglycosides, macrolides, tetracyclines, sulfa drugs, and urinary antisepticsTenosynovitis due to mycobacteria other than tuberculosis: a hazard of water sports and hobbiesAzithromycin and clarithromycinThe role of new antibiotics for the treatment of infections in the emergency departmentAzithromycin and typhoidPediatric antimicrobial therapyInfection caused by nontuberculous mycobacteria: Clinical aspectsMedicine in Tropical AustraliaAzithromycin and ClarithromycinCommunity-acquired pneumoniaNew Macrolide AntibioticsJaime B. Friedman, MDThe Crisis in Antibiotic ResistanceLong-term oral antibiotic treatment: why, what, when and to whom? 15 March 1992Volume 116, Issue 6Page: 517-519KeywordsAntibioticsEndocarditisProphylaxisStaphylococcal infectionStreptococcal infectionsStreptococcal pharyngitisSurgeonsThoraxToxicityUpper respiratory tract infections Issue Published: 15 March 1992 PDF DownloadLoading ...