gebhart/patrepeval huggingface dataset:
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn (2007)

IgE/antigen-dependent mast cell activation plays a central role in immediate hypersensitivity and other allergic reactions. The Src family tyrosine kinase (SFK) Lyn is activated by the cross-linking of high-affinity IgE receptors (FcepsilonRI). Activated Lyn phosphorylates the FcepsilonRI subunits, beta and gamma, leading to subsequent activation of various signaling pathways. Lyn also plays a negative regulatory function by activating negative regulatory molecules. Another SFK, Fyn, also contributes to mast cell degranulation by inducing Gab2-dependent microtubule formation. Here we show that a third SFK, Hck, plays a critical role in mast cell activation. Degranulation and cytokine production are reduced in FcepsilonRI-stimulated hck(-/-) mast cells. The reduced degranulation can be accounted for by defects in Gab2 phosphorylation and microtubule formation. Importantly, Lyn activity is elevated in hck(-/-) cells, leading to increased phosphorylation of several negative regulators. However, positive regulatory events, such as activation of Syk, Btk, JNK, p38, Akt, and NF-kappaB, are substantially reduced in hck(-/-) mast cells. Analysis of lyn(-/-)hck(-/-), lyn(-/-)FcepsilonRIbeta(-/-), and hck(-/-)FcepsilonRIbeta(-/-) cells shows that Hck exerts these functions via both Lyn-dependent and Lyn-independent mechanisms. Thus, this study has revealed a hierarchical regulation among SFK members to fine-tune mast cell activation.
Interactions between antacids and other drug treatments (1992)

Die Anwendung von Antacida führt im allgemeinen nicht zu erwähnenswerten Nebenwirkungen, da sie nicht systemisch wirken. Die Fähigkeit der meisten Antacidapräparate zur Komplexbildung mit Metall-Ionen, zur Bildung unlöslicher Salzverbindungen mit anderen ionischen Substanzen sowie zur Veränderung des pH-Wertes im Magen hat jedoch erheblichen Einfluß auf die Resorption anderer Medikamente und damit auf ihre Bioverfügbarkeit. Bei Antibiotika, wie z. B. Tetracyclinen, wird sie bis zu 90 % reduziert. Hemmwirkungen sind auch für Beta-Blocker, Captopril, Digitalis, H2-Rezeptorantagonisten, Eisen, nichtsteroidale Antirheumatika und Theophyllin gefunden worden. Für viele Substanzen sind die Dosierung und die Dosierungszeit entscheidend. Wenn Medikamente und Antacida in nüchternem Zustand gemeinsam eingenommen werden, ist ein größeres Interaktionsrisiko zu erwarten, als wenn die einzelnen Präparate zeitlich versetzt angewendet werden.
.beta.-Secondary and Solvent Deuterium Kinetic Isotope Effects and the Mechanisms of Base- and Acid-Catalyzed Hydrolysis of Penicillanic Acid (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.beta.-Secondary and Solvent Deuterium Kinetic Isotope Effects and the Mechanisms of Base- and Acid-Catalyzed Hydrolysis of Penicillanic AcidS. A. Deraniyagala, S. A. Adediran, and R. F. PrattCite this: J. Org. Chem. 1995, 60, 6, 1619–1625Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/jo00111a020https://doi.org/10.1021/jo00111a020research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Temporal filtering for depth maps generated by Kinect depth camera (2011)

We propose a method of filtering depth maps provided by Kinect depth camera. Filter uses output of the conventional Kinect camera along with the depth sensor to improve the temporal stability of the depth map and fill occlusion areas. To filter input depth map, the algorithm uses the information about motion and color of objects from the video. The proposed method can be applied as a preprocessing stage before using Kinect output data.
Calixarene-Based Molecules for Cation Recognition (2002)

This review discusses molecular design principles of calixarene-type macrocycles for ion recognition and gives examples on the relationship between structure and selectivity, however without attempting to cover all the different approaches.
Abstract S3-2: Neoadjuvant Pertuzumab (P) and Trastuzumab (H): Antitumor and Safety Analysis of a Randomized Phase II Study ('NeoSphere') (2010)

Abstract Background: P binds to HER2 and has complementary mechanisms of action with H. A clinical study of P+H showed meaningful activity in patients (pts) with metastatic HER2-positive breast cancer whose disease progressed on prior H therapy (Baselga et al. JCO 2010). NeoSphere is a Phase II randomized trial of preoperative systemic therapy comparing H and docetaxel (TH), THP, HP and TP to rank antitumor activity and tolerability. Methods: 417 pts with centrally-confirmed HER2-positive (IHC 3+ or FISH positive) breast cancer (stage II or III including locally advanced) were randomized to receive 4 cycles of TH (n=107), THP (n=107), HP (n=107), or TP (n=96) before surgery. Cycles were given intravenously q3w: P, 840 mg loading dose and 420 mg maintenance; H 8 mg/kg loading dose and 6 mg/kg maintenance; T, 75 mg/m2 with escalation to 100 mg/m2 if the starting dose was well tolerated. After surgery all pts received H to 1 year and 3 cycles of FEC; in case of neoadjuvant HP they also received T before FEC. The primary endpoint was rate of pathological complete response (pCR) in the breast. For all patients, a tissue sample at baseline, as well as at surgery following 4 cycles of neoadjuvant therapy, was collected for biomarker analyses. Results: Baseline characteristics were well balanced. About 40% of patients had locally advanced/inflammatory breast cancer. In the intent-to-treat analysis the rates of pCR and clinical objective response in the breast were: pCR for THP was significantly higher (p=0.014) than TH which was significantly higher than HP (p=0.031). Clinical disease progression was reported in 1 patient on TH and 2 patients on HP. Feasibility was good for all T-containing arms. Adverse events of grade ≥3 were rare (&lt;7%) with HP in sharp contrast with the &gt;50% incidence in T-containing arms. One pt developed congestive heart failure with HP. Five more patients had asymptomatic decreased LVEF with TH (1), THP (3) and TP (1) that resolved at the subsequent assessment. Biomarker analysis is ongoing. Conclusions: These data show the superior antitumor activity of THP and very favorable therapeutic ratio for HP that justify continuing study of the two monoclonals with and without docetaxel in women with HER2- positive early or metastatic breast cancer. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr S3-2.
Implement of High Speed and High Altitude Data Acquisition System Based on ARM and FPGA (2009)

A high speed high altitude experimental data acquisition system based on ARM and FPGA is introduced.The ARM processor is S3C2410 produced by Samsung,while the FPGA is EP2S15 which belongs to Stratix II serial and produced by Altera.ARM controls the experiment process by receiving the command send by PC on ground,and it sends back the collected target experimental data after the system triggered.The system hardware architecture and connectionswere are discussed,with the emphasis on design and implement of the software system.It′s a new system designing and building experience introduced in this paper on high speed and high altitude data collection.
Study of Energy Transfer and Triplet Exciton Diffusion in Hole‐Transporting Host Materials (2009)

Abstract A device structure is used in which the hole‐transporting layer (HTL) of an OLED is doped with either fluorescent or phosphorescent emitters, that is, anode/HTL‐host/hole blocker/electron‐transporting layer/cathode. The HTL hosts have higher HOMO energy allowing holes to be transported without being trapped by dopant molecules, avoiding direct recombination on the dopant. The unconventional mismatch of HOMO energies between host and dopant allow for the study of energy transfer in these host/guest systems and triplet exciton diffusion in the HTL‐host layers of OLED devices, without the complication of charge trapping at dopants. The host materials examined here are tetraaryl‐ p‐ phenylenediamines. Data shows that Förster energy transfer between these hosts and emissive dopant in devices is inefficient. Triplet exciton diffusion in these host materials is closely related to molecular structure and the degree of intermolecular interaction. Host materials that contain naphthyl groups demonstrate longer triplet exciton diffusion lengths than those with phenyl substituents, consistent with DFT calculations and photophysical measurements.
Methotrexate, rituximab, and temozolomide in CNS lymphoma: The Mayo Clinic experience. (2013)

2058 Background: We present a tertiary center experience with high-dose methotrexate, rituximab and temozolomide (MRT) chemotherapy in both primary and secondary CNS lymphoma. Methods: A retrospective analysis was performed for a total of 27 patients (20 male, 7 female) who underwent treatment at Mayo Clinic, Rochester between November 2010 and October 2012. The median age was 63 years (range 23-73). Of these, 12 patients were diagnosed with primary CNS lymphoma, while 15 patients had secondary CNS lymphoma. All patients received at least 1 cycle of MRT. The most common histological subtype was diffuse large cell lymphoma (23 of 27 patients). Other histological subtypes were high grade lymphoma (2 patients), Burkitt’s lymphoma (1 patient) and Mantle cell lymphoma (1 patient). Results: Of 26 patients, who underwent imaging studies for response assessment after MRT, 14 patients achieved complete response (CR), 4 patients achieved partial response (PR), 2 patients had stable disease, while 6 patients had evidence of disease progression. Overall, the median number of chemotherapy cycles with MRT was 3 (range 1-6). For patients, who achieved CR, the median number of MRT cycles was 4 (range 2-6). MRT was well tolerated. Of 27 patients, who underwent their entire treatment at Mayo Clinic, grade 3 or higher treatment related toxicity were noted to be as follows – neutropenia (9/27), thrombocytopenia (4/27), anemia (7/29), and transaminitis (10/27). 16 of 27 patients proceeded to high dose chemotherapy and autologous stem cell transplant. Out of 16 patients, 14 received BCNU/Thiotepa as conditioning regimen, while 2 patients underwent BEAM conditioning. All 16 patients who underwent transplantation remain in CR at this time. Of the remaining 11 patients, 4 are being planned for autologous transplantation, 2 received and responded to salvage chemotherapy, while 5 patients died of progressive disease. Conclusions: Overall, the MRT regimen was well tolerated. Overall response rate was noted to be 67% (18 of 27 patients) and achieved CR in 54% patients (14 of 26 patients). Patients who underwent autologous stem cell transplantation as consolidation therapy continue to do well at a median followup of 12.5 months (range 2-20 months).
The RUNX family in breast cancer: relationships with estrogen signaling (2012)

The three RUNX family members are lineage specific master regulators, which also have important, context-dependent roles in carcinogenesis as either tumor suppressors or oncogenes. Here we review evidence for such roles in breast cancer (BCa). RUNX1, the predominant RUNX family member in breast epithelial cells, has a tumor suppressor role reflected by many somatic mutations found in primary tumor biopsies. The classical tumor suppressor gene RUNX3 does not consist of such a mutation hot spot, but it too seems to inhibit BCa; it is often inactivated in human BCa tumors and its haploinsufficiency in mice leads to spontaneous BCa development. The tumor suppressor activities of RUNX1 and RUNX3 are mediated in part by antagonism of estrogen signaling, a feature recently attributed to RUNX2 as well. Paradoxically, however RUNX2, a master osteoblast regulator, has been implicated in various aspects of metastasis in general and bone metastasis in particular. Reciprocating the anti-estrogenic tumor suppressor activity of RUNX proteins, inhibition of RUNX2 by estrogens may help explain their context-dependent anti-metastatic roles. Such roles are reserved to non-osseous metastasis, because ERα is associated with increased, not decreased skeletal dissemination of BCa cells. Finally, based on diverse expression patterns in BCa subtypes, the successful use of future RUNX-based therapies will most likely require careful patient selection.
The Histidin-rich Glycoprotein Pro186/Ser Polymorphism Is not Related to Myocardial Infarction in the ECTIM Study (1998)

The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.
Complexation of Ferrocene Derivatives by the Cucurbit[7]uril Host:  A Comparative Study of the Cucurbituril and Cyclodextrin Host Families (2005)

The formation of inclusion complexes between cucurbit[7]uril (CB[7]) and ferrocene and its derivatives has been investigated. The X-ray crystal structure of the 1:1 inclusion complex between ferrocene and CB[7] revealed that the guest molecule resides in the host cavity with two different orientations. Inclusion of a set of five water-soluble ferrocene derivatives in CB[7] was investigated by 1H NMR spectroscopy and calorimetric and voltammetric techniques. Our data indicate that all neutral and cationic guests form highly stable inclusion complexes with CB[7], with binding constants in the 10(9)-10(10) M(-)(1) and 10(12)-10(13) M(-1) ranges, respectively. However, the anionic ferrocenecarboxylate, the only negatively charged guest among those surveyed, was not bound by CB[7] at all. These results are in sharp contrast to the known binding behavior of the same guests to beta-cyclodextrin (beta-CD), since all the guests form stable inclusion complexes with beta-CD, with binding constants in the range 10(3)-10(4) M(-1). The electrostatic surface potentials of CB[6], CB[7], and CB[8] and their size-equivalent CDs were calculated and compared. The CD portals and cavities exhibit low surface potential values, whereas the regions around the carbonyl oxygens in CBs are significantly negative, which explains the strong affinity of CBs for positively charged guests and also provides a rationalization for the rejection of anionic guests. Taken together, our data suggest that cucurbiturils may form very stable complexes. However, the host-guest interactions are very sensitive to some structural features, such as a negatively charged carboxylate group attached to the ferrocene residue, which may completely disrupt the stability of the complexes.
Interventional EUS guided cholangiography. First description in Mexico of a novel, secure and feasible technique. A case report. (2008)

Endoscopic retrograde cholangio pancreatography (ERCP) is the procedure of choice for biliary decompression in individuals with obstructive jaundice. In those cases when ERCP fails, the alternatives are to refer the case to a highly specialized center and repeat the procedure, or decompress the bile ducts either percutaneously or surgically. The proximity of the endoscopic ultrasound (EUS) probe from the stomach and duodenum to the hepatobiliar system and pancreas allows ultrasound-guided access into the bile and pancreatic duct. We present what to our knowledge is the first description in Mexico of a therapeutic interventional EUS guided cholangiography in a patient with cholecystitis and choledocolithiasis in whom initial ERCP failed to decompress de bile duct.
PENTOSE REACTIONS. I. FURFURAL FORMATION (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPENTOSE REACTIONS. I. FURFURAL FORMATIONCharles D. Hurd and Lloyd L. IsenhourCite this: J. Am. Chem. Soc. 1932, 54, 1, 317–330Publication Date (Print):January 1, 1932Publication History Published online1 May 2002Published inissue 1 January 1932https://pubs.acs.org/doi/10.1021/ja01340a048https://doi.org/10.1021/ja01340a048research-articleACS PublicationsRequest reuse permissionsArticle Views950Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laser map aided visual inertial localization in changing environment (2018)

Long-term visual localization in outdoor environment is a challenging problem, especially faced with the cross-seasonal, bi-directional tasks and changing environment. In this paper we propose a novel visual inertial localization framework that localizes against the LiDAR-built map. Based on the geometry information of the laser map, a hybrid bundle adjustment framework is proposed, which estimates the poses of the cameras with respect to the prior laser map as well as optimizes the state variables of the online visual inertial odometry system simultaneously. For more accurate cross-modal data association, the laser map is optimized using multi-session laser and visual data to extract the salient and stable subset for localization. To validate the efficiency of the proposed method, we collect data in south part of our campus in different seasons, along the same and opposite-direction route. In all sessions of localization data, our proposed method gives satisfactory results, and shows the superiority of the hybrid bundle adjustment and map optimization.
E1a Transactivation of the Human <i>HSP70</i> Promoter Is Mediated through the Basal Transcriptional Complex (1989)

We have examined the promoter sequence requirements for E1a transactivation of the human HSP70 gene by using a transient cotransfection assay. A 5' deletion study has defined a basal transcription unit extending to -74 relative to the transcription initiation site which was fully E1a responsive. Further deletion, abolishing a CCAAT element at -67, drastically reduced basal and E1a-induced expression. A linker-scanner analysis has identified four functional elements within the basal transcription unit which may interact with CTF, SP1, TFIID, and an ATF/AP1-like factor. Sequences between -100 and -188 can partially compensate for mutations in these elements. No mutation specifically abolished E1a inducibility. Any reduction in absolute E1a-induced levels was accompanied by a corresponding reduction in absolute basal levels, thereby maintaining a constant relative fold induction. We conclude that E1a transactivation of the human HSP70 promoter does not require any single basal transcription element. We also examined an HSP70 promoter fragment, containing the CCAAT element at -67 and the purine-rich element at -54, out of its normal context by fusing it upstream of a transcriptionally inactive herpes simplex virus thymidine kinase deletion construct containing only the TATA box. The resulting chimeric promoter was fully E1a responsive. Mutagenesis of this promoter fusion demonstrated that the CCAAT element was essential for detectable basal and E1a-induced expression. Mutations in the purine-rich element resulted in an approximately 10-fold elevation in basal levels and rendered the promoter nonresponsive to E1a.
An Example of Machine Learning Applied in Additive Manufacturing (2018)

Artificial Intelligence has become ubiquitous in many application sectors nowadays. One field, machine learning, has proved to be promising for industries as it can solve complex problems thanks to various methods and algorithms. The present article is an example of machine learning with EBM, a recent additive manufacturing technology. Several algorithms are tested onto the manufacturing of a part in order to check which results can extrapolate at the best the deformation risks vs the quality of the part to build. In this example, a few parameters of support structures are identified and are varied to observe the algorithms validity.
The role of the T-cell receptor in thymocyte maturation: effects in vivo of anti-receptor antibody. (1986)

The T-cell receptor, which recognizes antigen plus a product of the major histocompatibility complex, has been postulated to drive T-cell maturation in the thymus by engaging major histocompatibility complex proteins expressed on thymic stromal cells. We tested this idea by injecting neonatal animals with an anti-receptor antibody, KJ16, that binds to about 20% of T cells and is capable of blocking receptor function. In the presence of this antibody, mature T cells bearing the KJ16 epitope failed to develop. On the other hand, although the antibody could be shown to bind to receptors on cortical thymocytes, it did not prevent the rapid expansion or survival of the bulk of the KJ16+ cells in this population. These results are consistent with the hypothesis that most cortical thymocytes arise by a receptor-independent mechanism and that only a small proportion of these cells mature by a process dependent on receptor-major histocompatibility complex interactions.
On the Passing of My Good Friend John (1995)

September 26, 1937—December 6, 1994 On the Passing of My Good Friend John After this death it will be easier To pass beyond, to go where he went Out ofthis light into a greater light. —James Still ...