gebhart/patrepeval huggingface dataset:
Immunological discrimination between the human apolipoprotein E2(Arg158—-Cys) and E3 isoforms. (1992)

A specific anti-apoE2(Arg158----Cys) monoclonal antibody was raised by means of immunization of mice with a variant specific synthetic peptide. The peptide sequences used were homologous to apolipoprotein E of human and mouse. Consequently, the mouse immune system was tolerant to most of the selected sequences. Immunization with only one of selected peptides (amino acids 154-172) evoked an anti-peptide and anti-native protein response. Surprisingly, this peptide was predicted to have a low antigenicity index, in contrast to the other used peptides. The variant specific anti-peptide MAb that was generated with this sequence, recognizes apoE2(Arg158----Cys) and not apoE3. We here describe a sensitive, time saving, and simple immunoblot assay to detect apoE2(Arg158----Cys) in human sera without prior isoelectric focusing of serum proteins.
Narrow-bandpass multilayer mirrors for an extreme-ultraviolet Doppler telescope (1999)

We have developed narrow-bandpass MoSi/Si multilayer mirrors for a Japanese sounding-rocket program. A high spectral resolution lambda/Deltalambda exceeding 40 was achieved by a two-mirror telescope with a multilayer coating. The single telescope had two bandpasses in the extreme-UV range for detecting a coronal high-velocity flow; the wavelength at peak reflectance (hereafter peak wavelength) in one of the bandpasses was 210.2 A, situated on the blue side of the target's Fe XIV 211.3-A coronal emission line, and the peak wavelength in the other was 213.3 A on the red side. A high uniformity in a peak wavelength of less than 1 A was achieved over a primary (secondary) mirror surface 158 (96) mm in diameter. The ratio of the reflectance for the Fe XIV line at 211 A to that for an intense He II line as a contaminant at 304 A in the telescope system became 2 x 10(5) owing to a wave trap consisting of a single Si layer on the MoSi/Si multilayer. The narrow-bandpass (approximately 5-A) telescope was launched on 31 January 1998 by sounding rocket S520CN-22, and images of the whole-Sun corona at Fe XIV 211 A were successfully obtained.
Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning (2021)

Numerous animal studies have demonstrated that fear acquisition and expression rely on the coordinated activity of medial prefrontal cortex (mPFC) and amygdala and that theta oscillations support interregional communication within the fear network. However, it remains unclear whether these results can be generalized to fear learning in humans. We addressed this question using intracranial electroencephalography recordings in 13 patients with epilepsy during a fear conditioning paradigm. We observed increased power and inter-regional synchronization of amygdala and mPFC in theta (4 to 8 hertz) oscillations for conditioned stimulus (CS+) versus CS-. Analysis of information flow revealed that the dorsal mPFC (dmPFC) led amygdala activity in theta oscillations. Last, a computational model showed that trial-by-trial changes in amygdala theta oscillations predicted the model-based associability (i.e., learning rate). This study provides compelling evidence that theta oscillations within and between amygdala, ventral mPFC, and dmPFC constitute a general mechanism of fear learning across species.
Imazaquin Spray Retention, Foliar Washoff and Runoff Losses under Simulated Rainfall (1996)

Spray retention and foliar washoff of imazaquin in smooth pigweed (Amaranthus hybridus L.) and sicklepod (Senna obtusifolia (L.) Irwin and Barneby) were investigated. Imazaquin (70 g AI ha−1) was applied alone, with nonionic surfactant ‘X-77’ or organosilicone-based nonionic surfactant ‘Kinetic’ to plants at two- to five-leaf stage and subjected to 2·5 cm rainfall in 20 min either 1 or 24 h after application. Imazaquin spray retention was higher with adjuvants than without. Retention was similar between adjuvants in smooth pigweed but ‘Kinetic’ retained twice as much imazaquin as ‘X-77’ in sicklepod. Rainfall 1 h after application washed off three-quarters of foliar residues regardless of plant species or adjuvant. However, at 24 h after application, foliar washoff was lowest with ‘Kinetic’ followed by ‘X-77’ in both species. Imazaquin washoff ranged from 33 to 88% in the two species at 24 h after application. Overall, imazaquin activity was similar with either adjuvant in smooth pigweed but ‘Kinetic’ was more effective than ‘X-77’ in sicklepod. Runoff losses from the surface of a Bosket sandy loam (Mollic Hapludalfs) soil in runoff trays (1·2% slope) were also studied. Imazaquin was applied as above to trays with and without smooth pigweed canopy. A 2·5-cm rainfall was applied in 20 min at 24 h after application. Runoff samples collected in one-litre fractions were analyzed by enzyme-linked immunosorbent assay. Sediment (but not water) in runoff was greatly reduced (56%) by pigweed cover as compared to bare trays. Imazaquin in the first litre of runoff was higher than in subsequent runoff fractions regardless of pigweed cover. Total imazaquin lost in runoff was higher in pigweed cover (23%) than bare trays (16% of applied). Imazaquin concentration in 10–20 cm soil depth in pigweed cover trays was higher than in bare trays. These results suggest that imazaquin is vulnerable to foliar washoff and the herbicide washed off could move in the aqueous phase due to shorter contact time with soil for sorption.
There's more to hard materials than tungsten carbide alone (2011)

For most people hard materials are synonymous with tungsten carbide. But anyone attending a special seminar on the topic at the PM World Congress in Florence would have left with a distinctly different view. Ken Brookes reports…
Cinematic Infrared Scene Simulator Based On Vanadium Dioxide Spatial Modulator (1984)

This paper describes a cinematic infrared scene projector based on the use of a thin film of vanadium dioxide as a spatial/temporal modulator in the 8-12 μm wavelength band. Key features of the concept are discussed, including image writing by a scanned laser beam, image erasure by a novel fast cooling and reheating process, and the avoidance of flicker in the output by the use of two optical channels coupled by a rotating framing mirror. Experimental data are given demonstrating the feasibility of operation at (512)<sup>2</sup> pixels per frame and 30 frames per second.
Hypertonic Induction of Aquaporin-5 Expression through an ERK-dependent Pathway (2000)

Aquaporin-5 (AQP5) is a water channel protein expressed in lung, salivary gland, and lacrimal gland epithelia. Each of these sites may experience fluctuations in surface liquid osmolarity; however, osmotic regulation of AQP5 expression has not been reported. This study demonstrates that AQP5 is induced by hypertonic stress and that induction requires activation of extracellular signal-regulated kinase (ERK). Incubation of mouse lung epithelial cells (MLE-15) in hypertonic medium produced a dose-dependent increase in AQP5 expression; AQP5 protein peaked by 24 h and returned to baseline levels within hours of returning cells to isotonic medium. AQP5 induction was observed only with relatively impermeable solutes, suggesting an osmotic pressure gradient is required for induction. ERK was selectively activated in MLE-15 cells by hypertonic stress, and inhibition of ERK activation with two distinct mitogen-activated extracellular regulated kinase kinase (MEK) inhibitors, U0126 and PD98059, blocked AQP5 induction. AQP5 induction was also observed in the lung, salivary, and lacrimal glands of hyperosmolar rats, suggesting potential physiologic relevance for osmotic regulation of AQP5 expression. This report provides the first example of hypertonic induction of an extrarenal aquaporin, as well as the first association between mitogen-activated protein kinase signaling and aquaporin expression.
Electron‐beam crystallized large grained silicon solar cell on glass substrate (2011)

ABSTRACT Thin film hetero‐emitter solar cells with large‐grained poly‐silicon absorbers of around 10 µm thickness have been prepared on glass. The basis of the cell concept is electron‐beam‐crystallization of an amorphous or nanocrystalline silicon layer deposited onto a SiC:B layer. The SiC:B layer covers a commercially well available glass substrate, serving as diffusion barrier, contact layer and dopand source. For silicon absorber deposition a low pressure chemical vapour deposition was used. The successively applied e‐beam crystallization process creates poly‐silicon layers with grain sizes up to 1 × 10 mm 2 with low defect densities. The high electronic quality of the absorber is reflected in open circuit voltages as high as 545 mV, which are realized making use of the well‐developed a‐Si:H hetero‐emitter technology. Copyright © 2011 John Wiley & Sons, Ltd.
Differences in decorin expression by papillary and reticular fibroblasts <i>in vivo</i> and <i>in vitro</i> (1993)

Immunostaining of adult human skin shows that the small dermatan sulphate proteoglycan decorin is abundant in the whole dermal layer but absent from the epidermis. In the papillary layer adjacent to the dermal-epidermal border, more decorin was detected than in the reticular layer of the dermis. Expression of decorin mRNA by cells in the papillary dermis could also be shown by in situ hybridization. In contrast, biglycan, another small chondroitin sulphate/dermatan sulphate proteoglycan, is found only at the dermal-epidermal border. Therefore the biosynthesis of these two proteoglycans by papillary and reticular fibroblasts from two different donors was compared in tissue culture. Papillary fibroblasts secrete up to 5.9 times more decorin than reticular fibroblasts, while the amounts of cell-associated decorin in both cell types are similar. By Northern blot analysis as well as by in situ hybridization it was shown that papillary fibroblasts contain more mRNA coding for decorin than do reticular cells. In addition, no mosaic pattern of decorin expression was found in the cultured cells. The expression and synthesis of biglycan compared with decorin was about 10 times lower and did not show any significant differences for the two cells types. The kinetics of secretion and the rate of endocytosis of decorin were similar for both types of fibroblasts. These results were found with fibroblasts between the 9th and 15th passage from a newborn subject as well as from a 78-year-old donor, indicating that the pattern of decorin synthesis is not age-dependent in the range investigated. These results further show that fibroblasts from different layers of the dermis have a specific pattern of synthesis of small chondroitin sulphate/dermatan sulphate proteoglycans, and they also maintain these patterns in cell culture.
Novel Primer-Probe Sets for Detection and Identification of Mycobacteria by PCR-Microarray Assay (2012)

ABSTRACT A PCR-microarray assay was developed in which PCR primers and hybridization probes were designed for the 16S rRNA genes of 16 clinically relevant mycobacteria and for IS 6110 of Mycobacterium tuberculosis . The assay, based on a multiplex PCR followed by hybridization with oligonucleotide probes, was tested against 16 Mycobacterium species and 70 clinical samples.
Breakerless High Frequency Ignition Systems for Reciprocating Aircraft Engines (1963)

<div class="htmlview paragraph">Spark plug fouling and ignition timing changes due to breaker point wear and burning are major aircraft engine maintenance problems and cause significant performance penalties. The breakerless high frequency ignition system eliminates all breaker point and timing problems. In addition, the output voltage rise characteristics virtually eliminate spark plug fouling.</div> <div class="htmlview paragraph">The system is a condenser discharge type. The condenser being charged from a rectified magneto generator and discharged by a silicon controlled switch. Timing is controlled by a stationary magnetic pick-up and a rotating timed paddle wheel which incorporates the required cylinder compensation.</div>
Therapeutic Effect of Litong on Adiposis Hepatica (2010)

Objective To investigate the effects of Litong on blood fat and cholesterol of rats suffering from adiposis hepatica induced by high fat diet.Methods The rat hyperlipidemia model was induced by intragastric administration of 4 % cholesterin and 30-40℃ pork fat.The model rats were divided into four groups: Litong groups(300 mg/kg,150 mg/kg,75 mg/kg) and model group.After 60 days administration,the serum total cholesterol,triglyceride,high and low density lipoprotein were detected.And the liparoid changes of livers were observed by eye and light microscopy after the rats were killed.Results Compared with the model group,the levels of total cholesterol,triglyceride and low density lipoprotein in 300 mg/kg and 150 mg/kg groups were decreased signif icantly.However,Litong had little effect on high density lipoprotein.Pathological results showed that Litong(300 mg/kg and 150 mg/kg) could obviously lighten the fatty degeneration of liver cells.Conclusion Litong can signifi cantly mediate and lower lipoid level and improve adiposis hepatica.
Nucleic acids. 12. Synthesis of the L enantiomer of 1-.beta.-arabinofuranosylcytosine and of O2, O2'-anhydro-1-.beta.-D-arabinofuranosylcytosine (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleic acids. 12. Synthesis of the L enantiomer of 1-.beta.-arabinofuranosylcytosine and of O2, O2'-anhydro-1-.beta.-D-arabinofuranosylcytosineWilliam J. Wechter, Duane T. Gish, and Gary L. NeilCite this: J. Med. Chem. 1971, 14, 9, 882–883Publication Date (Print):September 1, 1971Publication History Published online1 May 2002Published inissue 1 September 1971https://pubs.acs.org/doi/10.1021/jm00291a027https://doi.org/10.1021/jm00291a027research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid. (1993)

The chemotactic peptide fMLP (N-formyl-methionyl-leucyl-phenylalanine) induced the production of platelet-activating factor (PAF) by human polymorphonuclear leukocytes (PMN) incubated with cytochalasin B (CB). CoA-independent transacylase showed similar activity in both resting and stimulated PMN, and PAF production only occurred when lyso-PAF:acetyl-CoA acetyltransferase had been converted into the high activity form. PAF formation was coincidental with an increase of the concentration of cytosolic Ca2+ ([Ca2+]i), and with an enhanced formation of 1-O-[3H]alkyl-2-acyl-sn-glycerol. Both fMLP-induced PAF production and the activation of lyso-PAF:acetyl-CoA acetyltransferase were diminished by propranolol. Since several molecular species of phosphatidic acid (PA) produced an inhibition of both PAF production and acetyltransferase activation on intact cells, a portion of the inhibitory effect of propranolol was related to the accumulation of PA. Furthermore, whereas CB increased both the extent and the duration of the fMLP-induced [Ca2+]i transient, propranolol was found to inhibit the CB-induced increase of the [Ca2+]i transient. These data indicate that both the attenuation of [Ca2+]i transient and the accumulation of PA may operate as termination signals for PAF production by actin on lyso-PAF:acetyl-CoA acetyltransferase.
Energy Efficient Protocols for Wireless Systems (2005)

This paper summarizes recent advances in energy efficient and low power design of networking protocols. We focus on the MAC (Medium Access Control) and application layers of the protocol stack. Of the five MAC protocols studied, EC-MAC has the best energy efficiency. EC-MAC also offers the best scalability with respect to the number of mobile terminals being serviced, as its energy consumption remains bounded. Power conservation techniques discussed for processing multimedia information at the application layer include transferring majority of the processing out of the terminal and into the network, tolerably deteriorating the video quality to lower data rates, and selectively discarding video frames.
Gels and Jellies as a Dosage Form for Dysphagia Patients: A Review (2011)

Patient compliance and safety is now prominent on the agenda of healthcare companies. Dysphagia (swallowing dysfunction) is common in general populations and more common in elderly institutionalized patients and persons in long-term care facilities due to significant primary illnesses, including cerebrovascular accidents, neurodegenerative disorders, head and neck cancer, or head injury. To ensure safety during oral medication administration, patients with dysphagia require an appropriate oral dosage form or modification of the dosage form. However inappropriate drug administration in patients with dysphagia (i.e., the crushing of sustained-release or enteric-coated tablets or the administration of oral medications with water) is undesirable and may be associated with adverse events (e.g. choking episodes, adverse drug reactions resulting from the immediate release of drug from a sustained-release product, refusal to take medications). Hence, there is a need of alternative novel oral dosage form like gels and jellies to deliver drugs having a viscosity that can be easily swallowed without any discomfort to the patient preventing choking and suffocation. Hence, today the potential for such dosage form is promising because of patient compliance and improved quality of life. This review briefly describes the role of gels and jellies in dysphagia patients, its advantages and disadvantages, formulation considerations, evaluation parameters and reviews of gels and jellies for dysphagia patients which have been carried out. Keywords: Dysphagia, elderly patients, gels, jellies, patient compliance, semi-solid, dosage form, formulation of drugs, drug delivery, novel oral dosage
Mechanisms of signal loss in magnetic resonance imaging of stenoses (1993)

Some of the factors affecting the signal losses that occur in magnetic resonance images at a stenosis or other region of complex flow have been evaluated. The important determinants of dephasing within a volume element are the net gradient moments, which can be kept small even at long echo times. For compact gradient wave forms, the echo time by itself is unimportant and does not affect signal losses. Reducing the fraction of echo sampled is an alternate method to velocity compensation for reducing gradient moment dephasing that keeps higher moments small. The effects of reducing the fraction of echo sampled on the signal losses in flow distal to a stenosis have been measured experimentally. Another source of signal loss at a stenosis is the variation of the mean phase within a volume element that occurs for flow that varies from one phase encoded view to another. Changes in flow behavior between acquisitions lead to signal displacement in the image. These view to view changes have also been quantified.
The use of opioids in fibromyalgia (2010)

Fibromyalgia syndrome (FMS) is a chronic disorder of widespread pain with high personal and societal burdens. Although targeted pharmacotherapies have become available in recent years, it remains a challenging condition to treat. Despite no randomized controlled trials addressing the short- or long-term use of opioids in FMS, their use remains prevalent. In this article we discuss the role of opioids and other analgesics in the management of FMS, with particular focus on problems associated with their use. We review aspects of the pathophysiology of FMS and consider how specific factors may contribute to the lack of efficacy of opioids in this condition. Finally, we discuss drugs with combined opioid and anti-opioid action and their roles in FMS. There is insufficient evidence to recommend the routine use of opioids in FMS. As well as having a significant adverse effect profile, their inefficacy may be due to their inability to target the pathophysiologic processes involved in this central sensitization syndrome.
Weather changes and pain: perceived influence of local climate on pain complaint in chronic pain patients (1995)

Patients with chronic pain frequently report that changes in the weather influence their pain. This study investigated differences in the perceived influence of weather on pain among 558 chronic pain patients living in 4 cities (San Diego, California; Nashville, Tennessee; Worcester, Massachusetts; and Boston, Massachusetts) in the United States. Local climatologic data for each city were obtained from the National Climatic Data Center. All patients completed a weather questionnaire, and the information they provided was compared with demographic and weather variables. The majority of all patients believed that changes in the weather affected their pain. Pain patients who were younger and who had arthritis reported the most sensitivity to changes in weather. Weather sensitivity was unrelated to all other demographic variables and to geographic region. Cold and damp conditions were considered to influence pain the most. However, the perceived effect of weather on pain was not found to be related to regional climate. Thus, the belief that pain is worsened by living in a colder climate was not supported. An equilibrium theory of weather changes and pain is discussed. Further investigations are needed to identify the mechanisms involved in the effects of weather changes on pain.
Synthesis and biological activity of unsaturated carboacyclic purine nucleoside analogs (1987)

Two new carboacyclic nucleoside analogues, 9-[4-hydroxy-3-(hydroxymethyl)-2-butenyl]adenine (6) and 9-[4-hydroxy-3-(hydroxymethyl)-2-butenyl]guanine (5), modeled on the unsaturated carbocyclic nucleoside analogue neplanocin A (2), have been synthesized and tested for antiviral activity against HSV-2 and, in the case of 6, for activity against influenza and in vitro inhibition of S-adenosylhomocysteine hydrolase. The synthesis was accomplished through the coupling of either adenine or the guanine precursor 2-amino-6-chloropurine (15) to the key intermediate 1-(benzyloxy)-2-[(benzyloxy)methyl]-4-chloro-2-butene (13). Debenzylation of the N-9 adenine adduct gave 6 directly, while the product of the debenzylation of the N-9 adduct of 15 when treated with sodium hydroxide gave the guanine analogue 5. The carboacyclic guanine analogue (5) exhibited significant antiviral activity against HSV-2 (VR = 1.5, MIC50 = 65.6 micrograms/mL), a level of activity that is superior to that of ara-A but inferior to that of acyclovir. The adenine analogue 6 was active against HSV-2 only at a very high dose; it was devoid of antiviral activity against influenza type A2, and it lacked inhibitory activity against S-adenosylhomocysteine hydrolase.