gebhart/patrepeval huggingface dataset:
La situación y los cambios recientes en el sistema lácteo español: efectos en la industria (1994)

En este trabajo se analizan los principales cambios que ha sufrido el sistema alimentario espanol desde el ingreso en la CEE, en especial entre las industrias lacteas: cambios de estrategia, competitividad, estructuracion del grupo lider, lineas de actuacion del capital multinacional, cambios segun gamas de productos, relaciones con los proveedores y clientes,... Todos estos elementos se enmarcan en los grandes cambios experimentados por el conjunto del sistema, sobre todo los efectos de la aplicacion de la politica restrictiva comunitaria en choque frontal con la expansion que vivia el sector espanol en la decada anterior. El analisis se centra en el comportamiento del grupo cabecera, del cual se analiza la dinamica empresarial de los anos de pertenencia a la Comunidad; se presta especial atencion a la actuacion del capital publico.
Cylindrical panoramic image-based model for robot localization (2002)

Mobile robots must be able to learn, use and maintain models of their environments. Two fundamental and interrelated problems in mobile robotics are mapping and localization. We present here a new type of image-based map formed by panoramic models enriched with depth and 3D planarity information. We take an advantage of the scene geometry implicitly contained in the model to localize a mobile robot that is moving in the same environment. The novelty of this model compared to the existing image-based maps is that the motion of the robot is not restricted to a predefined path or locations close to the original images. Experimental results demonstrate this approach.
Personal Workspace for Large-Scale Data-Driven Computational Experiment (2006)

As the scale and complexity of data-driven computational science grows, so grows the burden on the scientists and students in managing the data products used and generated during experiments. Products must be moved and directories created. Search support in traditional file systems is arcane. While storage management tools can store rich metadata, these tools do not satisfy the nuances of the individual computational science researcher working alone or cooperatively. We have developed a personal workspace tool, myLEAD, that actively manages metadata and data products for users. Inspired by the Globus MCS metadata catalog and layered on top of the UK e-Science OGSA-DAI tool, myLEAD provides capture, storage and search tools to the computational scientist. In this paper we experimentally evaluate the performance of the myLEAD metadata catalog
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells (2017)

DNA endonuclease eight-like glycosylase 3 (NEIL3) is one of the DNA glycosylases that removes oxidized DNA base lesions from single-stranded DNA (ssDNA) and non-B DNA structures. Approximately seven percent of human tumors have an altered NEIL3 gene. However, the role of NEIL3 in replication-associated repair and its impact on modulating treatment response is not known. Here, we report that NEIL3 is localized at the DNA double-strand break (DSB) sites during oxidative DNA damage and replication stress. Loss of NEIL3 significantly increased spontaneous replication-associated DSBs and recruitment of replication protein A (RPA). In contrast, we observed a marked decrease in Rad51 on nascent DNA strands at the replication fork, suggesting that HR-dependent repair is compromised in NEIL3-deficient cells. Interestingly, NEIL3-deficient cells were sensitive to ataxia-telangiectasia and Rad3 related protein (ATR) inhibitor alone or in combination with PARP1 inhibitor. This study elucidates the mechanism by which NEIL3 is critical to overcome oxidative and replication-associated genotoxic stress. Our findings may have important clinical implications to utilize ATR and PARP1 inhibitors to enhance cytotoxicity in tumors that carry altered levels of NEIL3.
ChIP-seq and ChIP-chip data used in this study. (2015)

<p>The tracks are (from top): FNR ChIP-seq −O<sub>2</sub> (blue) with peaks upstream of a subset of genes labeled, FNR ChIP-chip in Δ<i>hns/ΔstpA</i> −O<sub>2</sub> (black), σ<sup>70</sup> subunit of RNAP ChIP-seq −O<sub>2</sub> (green), σ<sup>70</sup> subunit of RNAP ChIP-seq +O<sub>2</sub> (red), H-NS CHIP-chip +O<sub>2</sub> (light purple), H-NS ChIP-chip −O<sub>2</sub> (orange), IHF ChIP-chip −O<sub>2</sub> (purple), Fis ChIP-seq +O<sub>2 </sub><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003565#pgen.1003565-Kahramanoglou1" target="_blank">[30]</a> (aqua), β subunit of RNAP −O<sub>2</sub> (yellow), β subunit of RNAP +O<sub>2</sub> (dark purple), and genomic coordinates. Locations of FNR binding sites are also shown: predicted FNR binding sites (red lines), FNR ChIP-seq peaks (black lines), FNR peaks upstream of operons showing a FNR-dependent change in expression (blue lines), FNR peaks co-activated by NarL/NarP (green lines), FNR peaks co-activated by CRP (purple lines), and FNR peaks repressed by Fur (yellow lines).</p>
It Takes Two (1994)

Divorce is Tess Brien's business. As a top lawyer she's seen it all, and she's determined it'll never happen to her. The unthinkable happens and marriage is blown apart. Then Tess has to face the question she's always dreaded - what will happen to the children?
Effective Loading Dose of Teicoplanin for Hypoalbuminemic Patients Based on Evaluation of Serum Concentration of Unbound Drug (2008)

抗 MRSA薬である teicoplanin(TEIC)は，本院では主に高齢者や腎機能の低下した患者に適用されているが，それらの患者は低アルブミン(Alb)血症を伴うことが多い．TEIC の臨床薬物動態の特徴として，血清Alb との高いタンパク結合率(健常人では 9095)がある．低 Alb 血症患者では TEICのタンパク結合率は低下し，遊離型薬物濃度が上昇する結果，血中濃度推移のみならず抗菌活性も影響を受けると示唆されている．したがって，MRSAに感染した低Alb 血症患者に対するTEIC の治療効果を高めるためには，患者個々の遊離型薬物濃度を考慮した合理的な投与設計を確立する必要がある．TEICは負荷投与を必要とするため，特に，最初の3 日間に実施する負荷投与量について詳細に検討した．負荷投与期間において，Alb濃度が低い患者で血清中トラフ濃度は減少した．一方，血中濃度が定常状態となった維持投与期間においては，Alb濃度が低い患者で遊離型のトラフ濃度は逆に増加した．これらのトラフ濃度について，(総濃度/Alb 濃度)と遊離型濃度との間に良好な直線関係が見出されたため，患者個々のAlb 濃度と総濃度の測定から遊離型濃度を精度良く推定することが可能となった．そこで，低Alb血症患者において，遊離型濃度がMRSAに対するMIC
Temperature dependence of the <i>I-V</i> characteristics of Ni/Au Schottky contacts to AlGaN/GaN heterostructures grown on Si substrates (2017)

The forward current–voltage (I–V) characteristics of Ni/Au Schottky contacts on AlGaN/GaN heterostructures have been studied in this work. The electrical characteristics exhibited a strongly non-ideal behavior that could not be described by the thermionic emission theory. Hence, we used a “two diodes model,” considering both the presence of the Ni/AlGaN barrier and of a second barrier height at the AlGaN/GaN heterojunction. Capacitance–voltage (C–V) measurements enabled us to experimentally determine the properties of the two dimensional electron gas (2DEG) and, hence, of the second barrier at the AlGaN/GaN interface. Following this approach, the anomalous I–V curves could be explained. Moreover, the value of the barrier height at zero-electric field (flat-band barrier height) was introduced and determined with this procedure, and resulted in a good agreement with literature data based on photoemission measurements. This approach provides a valid procedure for an accurate determination of the barrier height in AlGaN/GaN heterostructures, and the results can have useful implications for the fabrication of AlGaN/GaN HEMTs devices.
Atomic Layer Deposited Molybdenum Nitride Thin Film: A Promising Anode Material for Li Ion Batteries (2014)

Molybdenum nitride (MoNx) thin films are deposited by atomic layer deposition (ALD) using molybdenum hexacarbonyl [Mo(CO)6] and ammonia [NH3] at varied temperatures. A relatively narrow ALD temperature window is observed. In situ quartz crystal microbalance (QCM) measurements reveal the self-limiting growth nature of the deposition that is further verified with ex situ spectroscopic ellipsometry and X-ray reflectivity (XRR) measurements. A saturated growth rate of 2 Å/cycle at 170 °C is obtained. The deposition chemistry is studied by the in situ Fourier transform infrared spectroscopy (FTIR) that investigates the surface bound reactions during each half cycle. As deposited films are amorphous as observed from X-ray diffraction (XRD) and transmission electron microscopy electron diffraction (TEM ED) studies, which get converted to hexagonal-MoN upon annealing at 400 °C under NH3 atmosphere. As grown thin films are found to have notable potential as a carbon and binder free anode material in a Li ion battery. Under half-cell configuration, a stable discharge capacity of 700 mAh g(-1) was achieved after 100 charge-discharge cycles, at a current density of 100 μA cm(-2).
Scar Formation: The Spectral Nature of Fetal and Adult Wound Repair (1996)

Ferguson, Mark W.J. B.D.S., Ph.D., F.F.D.; Whitby, David J. M.B., F.R.C.S.; Shah, Mamta M.B., Ph.D., F.R.C.S.; Armstrong, James M.D., F.R.C.S.; Siebert, John W. M.D.; Longaker, Michael T. M.D. Author Information
Effect of Aldicarb Soil Treatments on Growth and Yeild of Cotton (1978)

Effect of aldicarb soil treatment on the growth and yield of cotton crop was studied under semi-arid climatic and sandy loam soil conditions of Hissar. Aldicarb in the form of 10 per cent granules was applied as side dressing @ 1, 2 and 4 Kg a. i./ha two months after sowing of crop. Soil treatments were found to have positive effect on vegetative grow.h and yield of seed cotton. With the increase in treatment dosages, there was significant increase in the height of plants, number of branches, number of bolls and yield of seed cotton. The increase in yield of seed cotton in treated plots over control plots was 267.6, 565.3 and 872.5 Kg/ha at 1, 2 and 4 Kg treatment dosages, respectively.
Coordinated Control of Cholesterol Catabolism to Bile Acids and of Gluconeogenesis via a Novel Mechanism of Transcription Regulation Linked to the Fasted-to-fed Cycle (2003)

Bile acid metabolism plays an essential role in cholesterol homeostasis and is critical for the initiation of atherosclerotic disease. However, despite the recent advances, the molecular mechanisms whereby bile acids regulate gene transcription and cholesterol homeostasis in mammals still need further investigations. Here, we show that bile acids suppress transcription of the gene (CYP7A1) encoding cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis, also through an unusual mechanism not involving the bile acid nuclear receptor, farnesoid X receptor. By performing cell-based reporter assays, protein/protein interaction, and chromatin immunoprecipitation assays, we demonstrate that bile acids impair the recruitment of peroxisome proliferator-activated receptor-gamma coactivator-1alpha and cAMP response element-binding protein-binding protein by hepatocyte nuclear factor-4alpha, a master regulator of CYP7A1. We also show for the first time that bile acids inhibit transcription of the gene (PEPCK) encoding phosphoenolpyruvate carboxykinase, the rate-limiting enzyme in gluconeogenesis, through the same farnesoid X receptor-independent mechanism. Chromatin immunoprecipitation assay revealed that bile acid-induced dissociation of coactivators from hepatocyte nuclear factor-4alpha decreased the recruitment of RNA polymerase II to the core promoter and downstream in the 3'-untranslated regions of these two genes, reflecting the reduction of gene transcription. Finally, we found that Cyp7a1 expression was stimulated in fasted mice in parallel to Pepck, whereas the same genes were repressed by bile acids. Collectively, these results reveal a novel regulatory mechanism that controls gene transcription in response to extracellular stimuli and argue that the transcription regulation by bile acids of genes central to cholesterol and glucose metabolism should be viewed dynamically in the context of the fasted-to-fed cycle.
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1 (2009)

Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). Active Akt promotes differentiation of NPC into gamma-aminobutyric acid-containing (GABAergic) but not glutamatergic neurons. Disruption of the Pdk1 gene or expression of dominant-negative forms of Akt suppresses insulin-like growth factor (IGF)-1 enhancement of NPC differentiation into neurons in vitro and production of neocortical GABAergic neurons in vivo. Furthermore, active Akt increased the protein levels and transactivation activity of Mash1, a proneural basic helix-loop-helix protein required for the generation of neocortical GABAergic neurons, and Mash1 was required for Akt-induced neuronal differentiation. These results have unveiled an unexpected role of the PDK1-Akt pathway: a key mediator of extracellular signals regulating the production of neocortical GABAergic neurons.
A Smart Compression Scheme for GPU-Accelerated Volume Rendering of Time-Varying Data (2011)

The visualization of large-scale time-varying data can provide scientists a more in-depth understanding of the inherent physical phenomena behind the massive data. However, because of non-uniform data access speed and memory capacity bottlenecks, the interactive rendering ability for large-scale time-varying data is still a major challenge. Data compression can alleviate these two bottlenecks. But just simply applying the data compression strategy to the visualization pipeline, the interaction problem can not be effectively solved because a lot of redundant data still existed in volume data. In this paper, a smart compression scheme based on the information theory is present to accelerate large-scale time-varying volume rendering. A formula of entropy was proposed, which can be used to automatically calculate the data importance to help scientists analyze and extract feature from the massive data. Then lossy data compression and data transfer is directly operated on these feature data, the remaining non-critical data was discarded in the process, and GPU ray-casting volume render is used for fast rendering. The experiment results shown that our smart compression scheme can reduce the amount of data as much as possible while maintaining the characteristics of the data, and therefore greatly improved the time-varying volume rendering speed even when dealing with the large scale time-varying data.
Fatigue crack initiation and growth in a 35CrMo4 steel investigated by infrared thermography (2005)

ABSTRACT The present work is devoted to the investigation of fatigue crack initiation and growth in middle‐cycle fatigue (∼10 5 cycles). Smooth specimens made of 35CrMo4 quenched and tempered steel were loaded in fully reversed plane bending. Temperature field evolution in time was recorded with an infrared camera. The experimental results show that the local heating of metal under fatigue loading is a sensitive and accurate enough manifestation of small fatigue crack initiation. It is shown that the time evolution of the spatial standard deviation of the temperature field can be used to investigate the damage localization and to monitor both the crack initiation and the current location of the fatigue crack tip. This should help to investigate the behaviour of defect during cyclic loading.
Engineering Aspects of Industrial Liquid-Phase Air Oxidation of Hydrocarbons (2000)

Liquid-phase air oxidation of hydrocarbons, notably p-xylene, cumene, ethylbenzene/isobutane, cyclohexane, and n-butane, is of great scientific, technological, and commercial importance. This state-of-the-art paper covers the chemistry and engineering science aspects of these reactions. The role of uncatalyzed reactions and metal ion and mixed metal ion catalysts with bromide activation is discussed. An analysis is presented for the role of mass transfer in influencing the rate of reaction and selectivity for the desired product. Different types of reactors that are used, notably bubble-column reactors and mechanically agitated reactors, are analyzed, and a simple basis is provided for selection of reactors. Some emerging oxidation systems, notably oxidation of cycloalkenes (cyclohexene/cyclooctene/cyclododecene) and oxidation of isobutane under supercritical conditions, are presented. New strategies for conducting air oxidations, such as in biphasic systems (including fluorous biphasic systems), biocatalysis, photocatalysis, etc., are emerging and illustrate the considerable tailoring of the reaction microenvironment that is becoming possible. In some cases, it may be possible to manipulate chemo-, regio-, and enantioselectivity in these reactions.
Direct determinations of R/S enantiomer ratios of citronellic acid and related substances by nuclear magnetic resonance spectroscopy and high pressure liquid chromatography (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect determinations of R/S enantiomer ratios of citronellic acid and related substances by nuclear magnetic resonance spectroscopy and high pressure liquid chromatographyDonald Valentine Jr., K. K. Chan, C. G. Scott, K. K. Johnson, K. Toth, and G. SaucyCite this: J. Org. Chem. 1976, 41, 1, 62–65Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/jo00863a014https://doi.org/10.1021/jo00863a014research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Eicosapentaenoic acid geometrical isomer artifacts in heated fish oil esters (1989)

Abstract Gas liquid chromatography (GLC) on polar capillary columns showed that the ester of eicosapentaenoic acid (EPA) in distilled fish oil methyl and ethyl esters sometimes is accompanied by several artifacts. The same EPA artifacts did not arise from saponification and/or esterification but were formed in a significantly high yield during prolonged heating of the authentic acid. Physicochemical studies, isolation and partial degradation showed that these artifacts are mainly geometrical ( cis‐trans ) isomers of the natural cis ethylenic bonds of eicosapentaenoic acid. Several C 20 mono‐and diethylenic geometrical isomers were prepared and the GLC equivalent chain length values determined. On the basis of measured and calculated equivalent chain length values on two different GLC phases, some of the EPA artifacts were identified as 20:5‐Δ rans ‐5, cis ‐8, cis ‐11, cis ‐14, cis ‐17; 20:5‐Δ cis ‐5, trans ‐8, cis ‐11, cis ‐14, cis ‐17; and 20:5‐Δ cis ‐5, cis 8, cis ‐11, cis ‐14, trans ‐17. No evidence was found for any positional isomers.
High-power extreme-ultraviolet source based on gas jets (1998)

We report on the development of a high-power laser plasma extreme UV (EUV) source for EUV. The source is based on the plasma emission of a recycled jet beam of large Xe clusters and produces no particular debris. The source will be driven by a pulsed laser delivering 1500 W of focused average power to the cluster jet target. To develop condensers and to optimize source performance, a low-power laboratory cluster jet prototype has been used to study the spectroscopy, angular distributions, and EUV source images of the cluster jet plasma emission. In addition, methods to improve the reflectance lifetimes of nearby plasma-facing condenser mirrors have been developed. The resulting source yields EUV conversion efficiencies up to 3.8 percent and mirror lifetimes of approximately 10<SUP>9</SUP> plasma pulses, with further improvement anticipated.
Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2 (2011)

We conclude that berberine reduces oxidative stress and vascular inflammation, and suppresses atherogenesis via a mechanism that includes stimulation of AMPK-dependent UCP2 expression.
An Efficient Synthesis of New 2-Pyronyl-1,5-Benzodiazepine Derivatives (1999)

A series of 3,4-dihydro-2-pyronyl-1,5-benzodiazepines 4 was prepared by the reaction of DHA (dehydroacetic acid), o-PDA (orthophenylenediamine) and aromatic aldehydes in the presence of a catalytic amount of TFA (trifluoroacetic acid). 2-Pyronyl-1,5-benzodiazepines 6 in turn were synthesised from DHA, o-PDA and acetal [dimethyl formamide-dimethyl acetal (DMF-DMA) or dimethyl acetamide-dimethyl acetal (DMA-DMA)] under basic catalysis.
Industrial and Engineering Chemistry - "The Editor's Point of View" (1933)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTIndustrial and Engineering Chemistry - "The Editor's Point of View"Harrison E. HoweCite this: Ind. Eng. Chem. 1933, 25, 1, 1–4Publication Date (Print):January 1, 1933Publication History Published online1 May 2002Published inissue 1 January 1933https://pubs.acs.org/doi/10.1021/ie50277a001https://doi.org/10.1021/ie50277a001research-articleACS PublicationsRequest reuse permissionsArticle Views12Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Connexin Gene Transfer Preserves Conduction Velocity and Prevents Atrial Fibrillation (2011)

Connexin gene therapy preserved atrial conduction and prevented AF.