gebhart/patrepeval huggingface dataset:
Pitch-based non-intrusive objective intelligibility prediction (2017)

Automatic adjustment of the hearing aid according to the intelligibility for the user in the environment could be beneficial. While most intelligibility metrics require a clean speech reference, i.e. intrusive methods, this is rarely available in real-life. This paper proposes a non-intrusive intelligibility metric in which a reconstruction of the clean speech is used in the established intrusive short-time objective intelligibility (STOI) metric. The reconstruction of the clean speech is based on pitch-features of the desired source using a spatio-temporal harmonic model. This model takes advantage of both the spatial and spectral separation of the desired source and interferers to reconstruct the clean signal. The simulations show a high correlation between the proposed pitch-based STOI (PB-STOI) and the original intrusive STOI and hence is promising for online processing of intelligibility.
Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells (1997)

Porphyromonas gingivalis is a periodontal pathogen capable of invading primary cultures of normal human gingival epithelial cells (NHGEC). Involvement of P. gingivalis fimbriae in the invasion process was examined. Purified P. gingivalis 33277 fimbriae blocked invasion of this organism into NHGEC in a dose-dependent manner. DPG3, a P. gingivalis fimbria-deficient mutant, was impaired in its invasion capability approximately eightfold compared to its parent, strain 381. However, adherence of the mutant was only 50% reduced compared to the parent. Biotin labeling of NHGEC surface proteins revealed that two fimbriated strains, but not DPG3, bound a 48-kDa NHGEC protein. Adhesin-receptor interactions, such as fimbriae binding to a 48-kDa NHGEC surface receptor, may trigger activation of eukaryotic proteins involved in signal transduction and/or provoke the generation of surface P. gingivalis molecules required for internalization.
Learning and Building Together in an Immersive Virtual World (1999)

This paper describes the design, evaluation, and lessons learned from a project involving the implementation of an immersive virtual environment for children called NICE (Narrative-based, Immersive, Constructionist/Collaborative Environments). The goal of the NICE project was to construct a testbed for the exploration of virtual reality as a learning medium within the context of the primary educational reform themes of the past three decades. With a focus on informal education and domains with social content, NICE embraces the constructivist approach to learning, collaboration, and narrative development, and is designed to utilize the strengths of virtual reality: a combination of immersion, telepresence, immediate visual feedback, and interactivity. Based on our experiences with a broad range of users, the paper discusses both the successes and limitations of NICE and concludes with recommendations for research directions in the application of immersive VR technologies to children's learning.
Direct observation of a vacuum tunnel gap in a tunneling microscope using a transmission electron microscope (1995)

This article reports the observation of the vacuum tunnel gap between two conductors using a high resolution transmission electron microscope. A 2.5-mm-sq micromachined tunneling microscope chip has been fabricated with a minimum feature size of 0.4 μm. The chip fits into a modified side-entry transmission electron microscope holder. The electrostatic actuators and springs are designed to produce a large force which is linear with applied voltage to overcome the forces between the tip and sample. The tunnel gap is controlled by a purpose-built feedback controller. One-dimensional micromachines work reliably during observation of the tip apex in a transmission electron microscope, allowing the voltage and current to be changed while the tunnel gap is observed. Two-dimensional machines that can scan the tip have also been tested and shown to be functional.
Location aware decision engine to offload mobile computation to the cloud (2016)

The use of mobile devices for work and for entertainment is growing. However, some applications may consume too much battery or be too CPU intensive for those devices. One alternative is to dynamically offload parts of the computation of those applications to the Cloud, reducing the battery usage of the devices and improve the responsiveness of the applications. One of the biggest challenges in offloading is to decide whether offloading a certain computation should be performed or not, since the time and energy required to upload the code as well as the input parameters may be less advantageous than executing it locally. This paper proposes a location aware decision engine for mobile offloading. The proposed decision engine can be easily plugged into any offloading framework. Further, we propose a black-box approach to estimate a method's execution time using simple code annotations. An experimental evaluation indicates that location-aware offloading can reduce the energy usage by 50%, with a CPU overhead of approximately 10%.
High-quality GaN epitaxial layer grown by metalorganic vapor phase epitaxy on (111) MgAl2O4 substrate (1995)

We grew GaN crystals by metalorganic vapor phase epitaxy on (111) and (100) MgAl2O4 substrates. We obtained a single-crystal GaN layer with a specular surface on the (111) substrate. The full width of half-maximum of the x-ray rocking curve for a 3.6 μm thick GaN layer was 310 s, comparable to the reported values for GaN on Al2O3 substrates. In the room-temperature photoluminescence, a band-edge emission at around 360 nm was dominant. A smooth cleaved (11̄00) facet of the GaN epitaxial layer was obtained, assisted by the inclined (100) cleavage of the (111) MgAl2O4 substrate. We intend this cleaved facet, which is normal to the surface, to be used as a cavity mirror in a laser diode.
Performance of TOA estimation algorithms in different indoor multipath conditions (2004)

Using TOA to determine the distance between the transmitter and the receiver is the most popular technique for accurate indoor positioning. Accuracy of measuring the distance using TOA is sensitive to the bandwidth of the system and the multipath condition between the wireless terminal and the access point. The behavior of the distance measurement error using TOA techniques in LOS and OLOS indoor environments are substantially different. In general, as the bandwidth increases the distance measurement error decreases. However, for the so called undetected direct path (UDP) conditions the system exhibits substantially high distance measurement errors that can not be eliminated with the increase in the bandwidth of the system. In this paper we provide an analysis of the behavior of super-resolution and traditional TOA estimation algorithms in LOS, OLOS and UDP conditions in indoor areas. The analysis is based on the frequency domain measurements of the indoor radio channel propagations in several indoor areas with special attention to the UDP conditions.
You Can’t Judge a Book by Its Cover (2006)

he current issue of Circulation reports 2 apparently conflicting studies 1,2 pertaining to the highly controversial issue of transdifferentiation of bone marrowderived cells into cardiomyocytes. The study by Iwasaki et al 1 entailed intramyocardial injections of human CD34 progenitors 20 minutes after the creation of a myocardial infarction in sex-mismatched, immunodeficient athymic mice. The results, assessed 28 days after transplantation, demonstrate a dose-dependent improvement in regional and global left ventricular function, a limitation of remodeling, and an increase in capillary density. These functional benefits are associated with a cardiac differentiation of the engrafted CD34 cells demonstrated by a double immunofluorescent staining for human-and cardiac-specific markers. Expression of cardiac genes unraveled by real-time polymerase chain reaction is also taken as additional evidence for the cardiomyocytic conversion of the CD34 progenitor cells, although this conclusion is compounded by the concomitant observation of fusion events between human and mouse cells demonstrated by fluorescent hybridization in situ, using probes specific for these 2 species. Differentiation of the CD34 progenitors into smooth muscle and endothelial cells is also reported on the basis of similar double-staining immunofluorescent patterns. In contrast, the second article, by Gruh et al, 2 does not demonstrate any conversion of human endothelial progenitor cells cocultured with neonatal rat cardiomyocytes. This study has carefully deciphered the potential causes of artifacts that may arise from the use of flow cytometry and conventional 2-dimensional immunofluorescence microscopy and lead to misinterpretations of phenotypic changes incurred by transplanted cells. Indeed, even 3-dimensional confocal microscopy failed to provide a conclusive interpretation for approximately 12% of the doublestained cells (ie, those expressing markers of both endothelial and cardiac lineages), thereby highlighting the caution with which these putative transdifferentiation events should be analyzed. Failure of additional real-time polymerase chain reaction to detect cardiac transcription factors further supports the authors' skepticism about the ability of CD34 progenitor cells to cross their lineage boundaries, at least in this setting of coculture experiments.
IκBζ is a key driver in the development of psoriasis (2015)

Significance Psoriasis is an inflammatory skin disease affecting 2–3% of the population. IL-17A plays a key role in psoriasis pathogenesis, and antibodies targeting IL-17A have recently been approved for psoriasis treatment. Here we demonstrate that IκBζ is a key protein for IL-17A–driven effects in psoriasis. IκBζ was demonstrated essential for both TNFα/IL-17A– and IL-17A–induced expression of a panel of psoriasis-associated proteins. Moreover, IκBζ expression was increased in psoriatic skin, and in two different psoriasis mouse models we showed that psoriasis development was completely absent in IκBζ-deficient mice, but inducible in IL-17A– and TNFα-deficient mice. Finally, local abrogation of IκBζ function in mouse skin abolished psoriasis development. These findings uncover a novel crucial regulatory mechanism involved in psoriasis development.
Introductory Guide to Assembling and Operating Gas Diffusion Electrodes for Electrochemical CO<sub>2</sub> Reduction (2019)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTIntroductory Guide to Assembling and Operating Gas Diffusion Electrodes for Electrochemical CO2 ReductionKai LiuKai LiuMaterials for Energy Conversion and Storage, Department of Chemical Engineering, Delft University of Technology, 2629 HZ Delft, The NetherlandsMore by Kai Liu, Wilson A. SmithWilson A. SmithMaterials for Energy Conversion and Storage, Department of Chemical Engineering, Delft University of Technology, 2629 HZ Delft, The NetherlandsMore by Wilson A. Smith, and Thomas Burdyny*Thomas BurdynyMaterials for Energy Conversion and Storage, Department of Chemical Engineering, Delft University of Technology, 2629 HZ Delft, The Netherlands*E-mail: [email protected]More by Thomas Burdynyhttp://orcid.org/0000-0001-8057-9558Cite this: ACS Energy Lett. 2019, 4, 3, 639–643Publication Date (Web):February 11, 2019Publication History Received18 January 2019Accepted1 February 2019Published online11 February 2019Published inissue 8 March 2019https://pubs.acs.org/doi/10.1021/acsenergylett.9b00137https://doi.org/10.1021/acsenergylett.9b00137article-commentaryACS PublicationsCopyright © 2019 American Chemical Society. This publication is licensed under CC-BY-NC-ND. This publication is Open Access under the license indicated. Learn MoreArticle Views20990Altmetric-Citations170LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSupporting Info (4)»Supporting Information Supporting Information SUBJECTS:Catalysts,Electrical properties,Electrodes,Electrolytes,Layers Get e-Alerts
Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy (2017)

Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.
Single-molecule optical spectroscopy of autofluorescent proteins (2002)

Several genetically encoded autofluorescent proteins are now available, in which the emission arises from the formation of a fluorophore directly from the amino acids of the protein sequence. These proteins are heavily used in cellular biology to assess gene expression and protein localization. The optical behavior of such proteins has recently been described in vitro at the single-molecule level. These investigations have explored several yellow-emitting mutants of the green fluorescent protein (GFP), the red-emitting DsRed protein, and the dual-GFP cameleon construct designed for fluorescence resonant energy transfer sensing of calcium ion binding. A variety of blinking, switching, and fluctuation effects have been observed, showing that several dark states are accessible after optical excitation, arising from variations in charge state, isomerization state, and photobleaching. The single-molecule spectroscopy of these systems will be surveyed by describing several illustrative examples. Although the autofluorescent proteins available at present need improvement in order to reach the performance of laser dye fluorophores, the novelty of these systems and their ease of use in biological contexts requires a continuing effort to understand the photophysical behavior.
Developments in Gum Acacias for the Encapsulation of Flavors (1995)

Two species of gum acacia were found to provide substantially better protection against oxidation of encapsulated orange oil during storage than competing modified starches. While emulsification properties were similar, the orange oil encapsulated in both gums had higher surface oil and moisture contents and slightly lower retention than the orange oil encapsulated in the modified starches.
Automatic and scalable cloud framework for parametric studies using scientific applications (2016)

Many scientific applications are computationally expensive and often require a large pool of resources for large scale experiments within a reasonable time frame. With Cloud computing offers a new ...
CHOMP: Gradient optimization techniques for efficient motion planning (2009)

Existing high-dimensional motion planning algorithms are simultaneously overpowered and underpowered. In domains sparsely populated by obstacles, the heuristics used by sampling-based planners to navigate “narrow passages” can be needlessly complex; furthermore, additional post-processing is required to remove the jerky or extraneous motions from the paths that such planners generate. In this paper, we present CHOMP, a novel method for continuous path refinement that uses covariant gradient techniques to improve the quality of sampled trajectories. Our optimization technique both optimizes higher-order dynamics and is able to converge over a wider range of input paths relative to previous path optimization strategies. In particular, we relax the collision-free feasibility prerequisite on input paths required by those strategies. As a result, CHOMP can be used as a standalone motion planner in many real-world planning queries. We demonstrate the effectiveness of our proposed method in manipulation planning for a 6-DOF robotic arm as well as in trajectory generation for a walking quadruped robot.
Perioperative Immunonutrition in Patients Undergoing Cancer Surgery (1999)

Perioperative administration of a supplemented enteral formula significantly reduced postoperative infections and length of stay in patients undergoing surgery for cancer.
Dependence of polyatomic ion mobilities on ionic size (1974)

The ion mobilities of 11 negative ions in nitrogen have been measured using a plasma chromatograph. The ions range from small negative ions such as NO2− to large organic ions such as the parent negative ion of 1-naphthaldehyde, (C11H8O)−. The reduced ion mobilities for these negative ions, in addition to previously published ion mobilities of protonated hydrocarbons, were compared with the Langevin theory of ion mobility. The hard sphere average collision cross section between the ion and the neutral carrier gas N2 was estimated using two models: (1) static model where the ion is nonrotating and (2) rotational model where the ion is assumed to be rotating rapidly. Comparison of the calculated reduced ion mobilities with the experimental values reveals that the experimental collision cross sections are intermediate between those calculated using these two models. The experimental and calculated ion mobilities gave the best agreement using the mean collision cross section for the static and rotational models. The average deviation between the experimental and calculated ion mobilities was 4% for a total of 21 positive ions and 14 negative ions. These results suggest (1) the ion size is the dominant parameter affecting the ion mobility of large molecular ions and (2) the rotation of nonspherical ions must be considered.
An introgression line population of Lycopersicon pennellii in the cultivated tomato enables the identification and fine mapping of yield-associated QTL. (1995)

Methodologies for mapping of genes underlying quantitative traits have advanced considerably but have not been accompanied by a parallel development of new population structures. We present a novel population consisting of 50 introgression lines (ILs) originating from a cross between the green-fruited species Lycopersicon pennellii and the cultivated tomato (cv M82). Each of the lines contains a single homozygous restriction fragment length polymorphism-defined L. pennellii chromosome segment, and together the lines provide complete coverage of the genome and a set of lines nearly isogenic to M82. A field trial of the ILs and their hybrids revealed at least 23 quantitative trait loci (QTL) for total soluble solids content and 18 for fruit mass; these estimates are twice as high as previously reported estimates based on traditional mapping populations. For finer mapping of a QTL affecting fruit mass, the introgressed segment was recombined into smaller fragments that allowed the identification of three linked loci. At least 16 QTL for plant weight, 22 for percentage green fruit weight, 11 for total yield and 14 for total soluble solids yield were identified. Gene action for fruit and plant characteristics was mainly additive, while overdominance (or pseudo-overdominance) of wild species introgressions was detected for yield.
Power Spectral Analysis of Heart Rate Variability and Baroreflex Gain (1995)

Correspondence| November 01 1995 Power Spectral Analysis of Heart Rate Variability and Baroreflex Gain Alberto Malliani; Alberto Malliani 1Medicina Interna II, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy Search for other works by this author on: This Site PubMed Google Scholar Massimo Pagani; Massimo Pagani 1Medicina Interna II, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy Search for other works by this author on: This Site PubMed Google Scholar Federico Lombardi Federico Lombardi 1Medicina Interna II, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1995) 89 (5): 555–556. https://doi.org/10.1042/cs0890555 Article history Received: June 12 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Alberto Malliani, Massimo Pagani, Federico Lombardi; Power Spectral Analysis of Heart Rate Variability and Baroreflex Gain. Clin Sci (Lond) 1 November 1995; 89 (5): 555–556. doi: https://doi.org/10.1042/cs0890555 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1995 The Biochemical Society and the Medical Research Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Regioselective Silylation of Sugars through Palladium Nanoparticle-Catalyzed Silane Alcoholysis (2002)

Palladium(0)-catalyzed silane alcoholysis was applied to sugars for the first time using tert-butyldimethylsilane (TBDMS-H) and Ph(3)SiH as the silanes. The catalyst is a colloidal solution of Pd(0) generated in situ from PdX(2) (X = Cl(-), OAc(-)) and TBDMS-H in N,N-dimethylacetamide. The colloid has been characterized by dynamic light scattering and transmission electron microscopy and consists of catalytically highly active nanoparticles of approximately 2 nm diameter. The silane alcoholysis reaction is an effective method for the regioselective silylation of methyl and phenyl glycosides and generates hydrogen gas as the only side product. For many of the sugar substrates investigated, the distribution of regioisomers obtained is complementary to that of the traditional R(3)SiCl/base (base = pyridine, imidazole) methodology and gives convenient access to the 3,6- rather than the 2,6-silylated pyranosides, obtained as the main product by the silyl chloride method. The method also allows a selective axial silylation of levoglucosan and 1,3,5-O-methylidene-myo-inositol. In an attempt to rationalize the observed regioselectivities, ab initio predictions (HF/3-21G) have been made on the relative energies of some of the silylated products. They suggest that the observed regioselectivities do not reflect a kinetic vs thermodynamic product distribution but are induced by the silylation agent employed. Models for the possible origin of the observed regioselectivity in both silylation methods (silane- and silyl chloride-based) are discussed.