gebhart/patrepeval huggingface dataset:
Outcome After Proctectomy for Rectal Cancer in Department of Veterans Affairs Hospitals (1998)

Mortality rates after proctectomy in VA hospitals are comparable to those reported in other large series. Most postsurgical complications are associated with an increased 30-day mortality rate. Elevated presurgical blood urea nitrogen level, impaired sensorium, low serum albumin concentration, and partial thromboplastin time < or =25 seconds predict a high risk of 30-day mortality.
Protease and antiprotease concentrations in serum and vaginal fluid of patients with carcinoma of the cervix. (1980)

The capacity of malignant cells to invade and disseminate throughout the tissues is partly due to the fact that these cells synthesize and secrete proteases and plasminogen activators. Its growth can be inhibited by antiproteolytic substances in vitro or by natural inhibitors such as alpha-1-antitrypsin (A1AT) and alpha-2-macroglobulin (A2MG). It is a known fact that in cervical cancer, serum A1AT levels are elevated, but so far it has not been determined if serum proteolytic activity is elevated and if both occur simultaneously in vaginal fluid. 32 cases of invasive carcinoma of the cervix, and 25 non-cancerous women were studied. A1AT, A2MG, cathepsin B, trypsin inhibitory capacity (TIC), plasminogen and proteins in plasma and vaginal fluid were studied. In cancer cases, proteolytic activity of serum and vaginal fluid (cathepsin B) is elevated, when compared to controls (p less than 0.001). A1AT and A2MG levels are clearly elevated in plasma, but not in the vaginal fluid; TIC was elevated in serum in cancer cases (1.31 vs. 1.74 p less than 0.005) but was not altered in vaginal fluid. It was found that in cases of carcinoma in situ cathepsin B, plasminogen, A1At and A2MG and CIT were significantly increased (p less than 0.001, p less than 0.001, p less than 0.001 and p less than 0.01 respectively). In vaginal fluid the only statistically significant figure increased was cathepsin B (p less than 0.001). These studies show an altered protease-antiprotease balance in patients with carcinoma of the cervix uteri.
Survey of the year 2005 commercial optical biosensor literature (2006)

We identified 1113 articles (103 reviews, 1010 primary research articles) published in 2005 that describe experiments performed using commercially available optical biosensors. While this number of publications is impressive, we find that the quality of the biosensor work in these articles is often pretty poor. It is a little disappointing that there appears to be only a small set of researchers who know how to properly perform, analyze, and present biosensor data. To help focus the field, we spotlight work published by 10 research groups that exemplify the quality of data one should expect to see from a biosensor experiment. Also, in an effort to raise awareness of the common problems in the biosensor field, we provide side-by-side examples of good and bad data sets from the 2005 literature.
Phase II and III clinical development of GM2-KLH/ QS-21 vaccine for melanoma (1997)

Progenics Pharmaceuticals, Inc., Tarrytown, NY, USA, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY, USA
Aromatic azapentalenes. II. Reactions of monobenzo- and dibenzo-1,3a,4,6a-tetraazapentalenes (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAromatic azapentalenes. II. Reactions of monobenzo- and dibenzo-1,3a,4,6a-tetraazapentalenesRudolph A. Carboni, James C. Kauer, William R. Hatchard, and Robert J. HarderCite this: J. Am. Chem. Soc. 1967, 89, 11, 2626–2633Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://doi.org/10.1021/ja00987a021RIGHTS & PERMISSIONSArticle Views279Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1001 KB) Get e-Alertsclose Get e-Alerts
Threshold-based Collaborative Access Control (T-CAC) (2007)

Userpsilas information confidentiality and privacy rise with the increased usage of computers by various organizations. Abuse of privileges might occur when the trust is based on a single person. Moreover, access control models usually consider only regular policies and are not appropriate to unusual or exceptional circumstances. For instance, in case of emergencies many users might override the access control system in order to access unauthorized sensitive data which is undesirable.
Antitumor activity and interleukin-1 induction by tannins. (1993)

The relationships between structures, antitumor activities and interleukin-1 (IL-1) induction by fifteen tannins were studies. When tannins (10 mg/kg) were intraperitoneally injected into mice once, 4 days before intraperitoneal inoculation of S-180 cells, tellimagrandin II, rugosin A, hirtellin B, oenothein B and oenothein A, which have only tellimagrandins I or II units in their molecules, had significant antitumor activity. Although casuarictin and its related tannins were ineffective, agrimonin, which is a dimer, had a strong effect, as previously reported. On the other hand, monomeric ellagitannins such as tellimagrandins I and II, rugosin A and casuarictin also increased IL-1 beta production from human peripheral macrophages in vitro by 2-fold over the non-stimulated basal production and oligomeric ellagitannins with strong antitumor activity more potently stimulated the IL-1 beta induction. Other tannins having no antitumor activity induced less IL-beta. This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1 beta.
Study of the canard configuration with particular reference to transonic flight characteristics and low-speed characteristics at high lift (1949)

Report presenting a study of the flight characteristics of the canard configuration at transonic and supersonic speeds. Known problems concerning the low-speed characteristics of the canard are also investigated.
[Measurements of density distribution of high energy electrons by emission spectroscopy in pulsed discharge reactor]. (2008)

Pulsed streamer discharge can generates high energy electrons with energy higher than 11. 03 eV and enough to excite N2 to its C3 pi(u) state from the ground state, so the density of the high energy electrons can be obtained by diagnosing the relative emission spectrum intensity of the N2 (C 3 pi(u) --> B 3 pi(g)) emitted from the pulsed streamer discharge. In the present paper, the density distributions of high energy electrons in the wire-plate DeSO2 reactor with pulsed streamer discharge were studied in air at room temperature and 1 atm, and the influences of pulsed voltage and wire-to-wire spacing on the density distributions of high energy electrons were also studied. The experimental results show that high-energy electrons mainly centralize around the discharge wire of the wire-plate reactor, and the electron density reduces with the increase of the distance from the discharge wire. The pulse voltage has a great influence on the high energy electron density, and the high energy electron density increases linearly with increasing the pulsed voltage. Under a fixed wire-to-plate spacing, when the wire-to-wire spacing is 0. 6-1 times the wire-to-plate spacing, the density distributions of the high energy electrons are more uniformity.
The regulation of lung elastin synthesis (1990)

The important role that elastin plays in the development and proper function of lung has long been recognized. Also, the intimate connection between pulmonary emphysema and the destruction of alveolar elastin has been well established. Understanding the mechanisms regulating pulmonary elastin synthesis is crucial to fully understanding these normal and pathological processes. In this article, we review recent literature on elastin structure, the elastin gene and its multiple RNA transcripts, and the different tropoelastin isoforms that are translated from these mRNAs. The similarity of lung and aortic elastin and the cellular origin of lung elastin are also discussed. We next examine the few studies addressing regulation of elastin expression during lung development, maturation, and aging. The search for modulators of pulmonary elastogenesis, which has yielded mostly negative results, is then reviewed. Finally, we present a cell culture model that has been developed to study the molecular basis of lung injury in pulmonary emphysema.
Vertically Aligned ZnO Nanorod Arrays Sentisized with Gold Nanoparticles for Schottky Barrier Photovoltaic Cells (2009)

Vertically aligned zinc oxide (ZnO) nanorod arrays coated with gold nanoparticles have been used in Schottky barrier solar cells. The nanoparticles enhance the optical absorption in the range of visible light due to the surface plasmon resonance. In charge separations, photoexcited electrons are transferred from gold nanoparticles to the ZnO conduction band while electrons from donor (I−) in the electrolyte compensate the holes left on the gold nanoparticles. The fill factors of the dye-free Schottky barrier cell reach a value of ∼0.50. However, after incorporation of N719 sensitizing dye, the open circuit voltage increases to 0.63 V from 0.5 V being measured for dye-sensitized solar cells based on the bare ZnO nanorods. The Schottky barrier at the ZnO/Au interface blocks the electron transfer back from ZnO to the dye and electrolyte, and thus increases the electron density at the ZnO conduction band. The efficiency of the gold-coated ZnO nanorod dye-sensitized solar cells is thus increased from 0.7% to 1.2%.
Sampling in Fan Beam Tomography (1993)

In fan beam tomography, functions in $\mathbb{R}^2 $ are constructed from integrals along straight lines emanating from a finite number of sources sitting on a circle around the reconstruction region. Using a sampling theorem for periodic functions and asymptotic estimates for the Fourier transform of the fan beam transform, the exact sampling conditions are found for standard fan beam scanning necessary to obtain a certain resolution. New efficient sampling schemes and corresponding reconstruction algorithms are also found. These sampling schemes need significantly less data to obtain a certain resolution than a standard fan beam geometry. The correctness of the sampling conditions for standard fan beam scanning and the superiority of the new schemes are shown by computer simulations.
Initial stages in the morphogenesis of nitrogen-fixing stem nodules of Sesbania rostrata (1983)

Morphogenesis of stem nodules in Sesbania rostrata was studied over a period of 6 days after inoculation with an appropriate species of Rhizobium. Nodulation sites were initially slightly raised, circular areas 0.3 to 0.6 mm in diameter and 4 to 5 mm apart in vertical rows along the length of the stem. Each site was underlaid by an adventitious root primordium. A site became susceptible to infection by a specific Rhizobium sp. when the root primordium broke through the epidermis, leaving a fissure. Rhizobia multiplied within this fissure and colonized the exposed intercellular spaces. The infection extended inward as narrow, branched intercellular threads moved into a cortical meristematic zone, where cell division was initiated, and invagination of infection thread branches into adjacent plant cells followed. Rhizobia were released into the plant cells and surrounded immediately by plant membrane. Intracellular rhizobia divided actively, leading to bacteroid-filled cells. Infected areas enlarged and coalesced as the nodule matured.
Wear of Vitamin E-Infused Highly Cross-Linked Polyethylene at Five Years (2017)

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
A new procolophonid from the Upper Triassic of Texas, with a description of tooth replacement and implantation (1997)

ABSTRACT A new procolophonid, Libognathus sheddi, gen. et sp. nov. is reported from the Cooper Canyon Formation (Dockum Group; Upper Triassic: lower Norian) near Post, Texas. This is the first published description of an unequivocal procolophonid from the Upper Triassic of the southwestern United States. Some of the distinctive characters of Libognathus are the deep dentary, large anteriorly directed foramen on the lateral dentary surface, and the forward projecting coronoid. Libognathus provides a good example of tooth replacement and implantation, which are poorly known in procolophonids. The implantation is protothecodont, with the teeth set in sockets and firmly anchored by spongy bone of attachment. The stages of replacement are of the typical reptilian pattern. Libognathus is closely related to Hypsognathus from the Passaic Formation (Norian) of New Jersey, and correlative strata in Connecticut and Nova Scotia.
The Assessment of Sultriness. Part I: A Temperature-Humidity Index Based on Human Physiology and Clothing Science (1979)

Abstract Using as bases the amount of clothing needed to achieve thermal comfort and the reduction in the skin's resistance needed to obtain thermal equilibrium, the relative sultriness of warm-humid and hot-arid summer climates is assessed. Conditions of equal sultriness are referred to a vapor pressure of 1.6 kPa in order to prepare a table of apparent temperature corresponding to summer temperatures and humidities.
Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure (2014)

Many cellular proteins are 'disordered' in isolation. A subset of these intrinsically disordered proteins (IDPs) can, upon binding another molecule, fold to a well-defined three-dimensional structure. In the structurally heterogeneous, unbound ensemble of these IDPs, conformations are likely to exist that, in part, resemble the final bound form. It has been suggested that these conformations, displaying 'residual structure', could be important for the mechanism of such coupled folding and binding reactions. PUMA, of the BCL-2 family, is an IDP in isolation but will form a single, contiguous α-helix upon binding the folded protein MCL-1. Using the helix-breaking residue proline, we systematically target each potential turn of helix of unbound PUMA and assess the binding to MCL-1 using time-resolved stopped-flow techniques. All proline-containing mutants bound, and although binding was weaker than the wild-type protein, association rate constants were largely unaffected. We conclude that population of particular residual structure, containing a specific helical turn, is neither required for the binding nor for fast association of PUMA and MCL-1.
One‐pot synthesis of iimidazo[1,2‐<i>c</i>]quinazoline‐5(6<i>H</i>)‐thione and imidazo[1,2‐<i>c</i>]quinazolin‐5(6<i>H</i>)‐one with the aid of tin(II) chloride (2009)

Abstract magnified image An efficient, convenient, one‐pot synthesis of imidazo[1,2‐ c ]quinazoline‐5(6 H )‐thione and imidazo[1,2‐ c ]quinazolin‐5(6 H )‐one was accomplished in good yields via the novel reductive cyclization of 2‐(2‐nitrophenyl)‐1 H ‐imidazoles with isothiocyanates or isocyanates mediated by SnCl 2 ·2H 2 O system. J. Heterocyclic Chem., (2009).
Thermal Response Turbine Shroud Study. (1979)

The program objective was to evaluate active clearance controls (ACC) for future military fighter and transport aircraft/engines, rank the candidate schemes, and recommend a future course of action. Fifty-one potential ACC concepts were reduced to twelve: five mechanical, two pneumatic, and five thermal. The fighter and transport missions selected were the Advanced Tactical Fighter (ATF), and the C141X strategic aircraft. Three levels of controls for ACC were considered: simple on/off two-position; open loop infinitely variable; and feedback (requiring a clearance sensor). On/off systems were selected for study because the majority of the benefit is obtained during cruise/dash and the open and feedback systems have positioning and reliability uncertainties. The criteria selected to evaluate the different schemes were net Life Cycle Cost benefits, to the fleet over the life of the weapons system. These criteria were based on a new-engine/new-aircraft application where efficiency improvements due to ACC were used to reduce aircraft and engine size for a fixed mission (range, payload, etc.). The detailed operation and impact (cost, weight, reliability, maintainability) of the twelve final schemes were evaluated by adopting each of the candidate schemes to selected stages in the base engines. ACC showed a significant net benefit in the transport high pressure turbine. On the low pressure turbine some schemes showed a net savings, but the amount was small. For the fighter application, ACC showed a significant net benefit in the high pressure turbine only.
Development of a Phantom to Modulate the Maternal and Fetal Pulse Curve for Pulse Oximetry Measurements (2012)

For getting reliable information about the state of health from the fetus and the mother during labor and delivery, a fetal pulse oximeter is being developed. This paper describes the development of a special phantom to verify the algorithms for separating the weak fetal from the dominant maternal optical signal. To reach a realistic behavior it is necessary for two circulations to be controlled independently. Inspired by the natural blood circulation behavior, a RC-System with fixed resistance and capacity was created. Pumping a liquid with a roller pump into the tubes widens them. The digital signal processor (DSP) controls the expansion of the tube diameter by modifying the rotation velocity of the pump for active regulation. Therefore a soft and good enlargeable material was used. The measured values of the pressure sensor enabled active feedback for motor control The determined system characteristics are used to adapt the given pulse curve to the real system behavior. Via a LabView interface it is possible to change curve parameters like amplitude and frequency. The goal was to replicate the pulsation of the blood vessels like in the abdomen of a pregnant woman. Changing the parameters influences the modulation of the signal under consideration of the transfer function. With this phantom it is possible to simulate different scenarios, for example different states of pregnancy or pathogen indications.
1.5-GHz Band-Pass Microstrip Filters Fabricated Using EuBaCuO Superconducting Films (1993)

This letter reports the properties of 1.5-GHz band-pass microstrip filters fabricated using EuBacuO superconducting films. Although 3- and 4-pole filters constructed using a superconductor and a silver ground plane exhibited good reproducibility and very low insertion loss of 3∼5 dB at 70 K, in comparison with Cu filters with 16∼27 dB loss at 77 K, the insertion loss was almost constant at temperatures below 70 K. In contrast, the insertion loss in the 4-pole filter with a superconductive ground plane was 1.2 dB at 70 K and 0.6 dB at 28 K. The center frequency and bandwidth at -3 dB were, respectively, 1.45 GHz and 1.4% at temperatures below 70 K.
Concurrent Pin Access Optimization for Unidirectional Routing (2017)

In advanced technology nodes, standard cell pin access is becoming challenging due to a small number of routing tracks and complex design-for-manufacturing constraints. Pin access interference is further exacerbated by unidirectional routing, which is highly preferred to enable high-density metal patterns and comply with self-aligned multiple patterning solutions. Previous manufacturing-aware routing studies simply depend on the router or sequential planning schemes to resolve pin access interference, which introduces significant overhead on solution qualities. Therefore, we propose concurrent pin access optimization techniques to achieve fast and high-quality routing solutions. The concurrent pin access optimization is modeled as a weighted interval assignment problem, which is solved by an optimal integer linear programming formulation and a scalable Lagrangian relaxation algorithm. A concurrent pin access router is implemented while accommodating advanced manufacturing constraints, which outperforms state-of-the-art manufacturing-aware routers with better routability, fewer vias and faster runtime.
Context-aware telephony (2006)

The proliferation of cell phones has led to an ever increasing number of inappropriate interruptions. Context-aware telephony applications, in which callers are provided with context information about the receivers, has been proposed as a solution for this problem. This approach, however, raises many privacy issues that may render it infeasible. In this paper, we report on an in-situ study of user privacy preferences and patterns of sharing different types of context information with different social relations. We found that participants disclosed their context information generously, suggesting that context-aware telephony is not only feasible, but also desirable. Our data shows a distinct sharing pattern across social relations and different types of context information. We discuss the implications of the results for designers of context-aware telephony in particular and context-aware applications in general.
Frequency-domain-coupled microstrip-line normal-mode parameter extraction from S-parameters (2001)

We describe a frequency-domain normal-mode parameter (NMP) extraction method for asymmetric, uniform coupled microstrip lines. The method applies when loss is reasonably low or the lines are reasonably short, as is the case in many practical applications. The only requirement is the complete scattering parameter (S-parameter) description for a specified physical length of the coupled section. Extraction yields the frequency-dependent characteristic impedance matrix, the mode propagation constants, and the mode configurations; also the concomitant per-unit-length parameters. We develop quasi-TEM analytic expressions for the S-parameters in terms of the NMPs, and then validate the method for three lines by recovering the NMPs from this data and from simulated S-parameters.
Quantitative proteomics for identification of cancer biomarkers (2007)

Quantitative proteomics can be used for the identification of cancer biomarkers that could be used for early detection, serve as therapeutic targets, or monitor response to treatment. Several quantitative proteomics tools are currently available to study differential expression of proteins in samples ranging from cancer cell lines to tissues to body fluids. 2-DE, which was classically used for proteomic profiling, has been coupled to fluorescence labeling for differential proteomics. Isotope labeling methods such as stable isotope labeling with amino acids in cell culture (SILAC), isotope-coded affinity tagging (ICAT), isobaric tags for relative and absolute quantitation (iTRAQ), and (18) O labeling have all been used in quantitative approaches for identification of cancer biomarkers. In addition, heavy isotope labeled peptides can be used to obtain absolute quantitative data. Most recently, label-free methods for quantitative proteomics, which have the potential of replacing isotope-labeling strategies, are becoming popular. Other emerging technologies such as protein microarrays have the potential for providing additional opportunities for biomarker identification. This review highlights commonly used methods for quantitative proteomic analysis and their advantages and limitations for cancer biomarker analysis.