gebhart/patrepeval huggingface dataset:
Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters. (2000)

Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. The present study investigates magnetic liposomes designed to act as anticancer drug carriers, which can be effectively delivered to solid tumors via intravenous administration. Magnetic liposomes with incorporated adriamycin (magnetic ADR liposomes) were prepared by the reverse-phase evaporation method, and an in vivo study was carried out to assess the magnetic targeting of these liposomes to hamster osteosarcoma. The average diameter of liposomes thus prepared was 146 nm. Syrian male hamsters inoculated with osteosarcoma, Os515, in the right hind limb were studied 7 days after inoculation. After the hamsters had received an intravenous administration of either magnetic ADR liposomes or ADR solution (corresponding to 5 mg ADR/kg), the ADR concentrations in plasma, tumor, liver, lung, heart, and kidney were determined at designated time intervals. Administration of magnetic ADR liposomes under magnetic force using a permanent magnet (0.4 tesla) implanted in solid tumor produced an approximately 4-fold higher maximum ADR concentration in the tumor than did administration of ADR solution. The former administration modality induced an increase in ADR concentration in the liver and lung and a decrease in the heart compared with concentrations produced by the latter. The present results indicated that intravenously administered magnetic ADR liposomes can be used to effectively deliver ADR to osteosarcoma implanted with a magnet, as well as to the lung, a common site of metastases for osteosarcoma. Our results also suggest that this new treatment approach, which involves a combination of magnet implantation at the target site and intravenous administration of magnetic liposomes, can improve the clinical chemotherapy of solid tumors.
Enantioselective Preparation of (2R)- and (2S)-Azetidine-2-carboxylic Acids (1998)

The enantiomerically pure amino ketones 13 and 31 were prepared starting from the commercially available amino diol 9 and D-serine (21), respectively. Irradiation afforded highly functionalized azetidinols 15 and 33 in a fully stereoselective manner and in high yields, whereas N-phenacylglycine 5 gave only the secondary products of a Norrish-Type-II cleavage. Compounds 15 and 33 were converted into (2R)- and (2S)-azetidine-2-carboxylic acids 20 and 37, respectively, in several steps. The influence of H-bonds on efficiency, chemo-, and stereoselectivity of the photochemical cyclization of 5, 13, and 31 was discussed. It was shown that conformational analysis of corresponding triplet biradicals is often valuable in understanding the photochemistry of amino ketones.
E2F Proteins Regulate MYCN Expression in Neuroblastomas (2003)

Amplification of the MYCN gene, resulting in overexpression of MYCN, distinguishes a subset of neuroblastomas with poor prognosis. The transcription factors driving MYCN expression in neuroblastomas are unknown. In transient-transfection assays, E2F-1, E2F-2, and E2F-3 activate a MYCN reporter construct dependent on the presence of several putative E2F-binding sites. Using chromatin immunoprecipitation, we show that E2F-1, E2F-2, and E2F-3 bind to the proximal MYCN promoter in vivo, specifically in neuroblastoma cell lines expressing MYCN. Inhibition of E2F activity in MYCN-amplified cells by the overexpression of p16(INK4A) reduced MYCN expression. In addition, we provide evidence that E2F proteins are involved in the negative regulation of MYCN by TGF-beta and retinoic acid. These data suggest that E2F transcription factors are critical for both the full activation and the repression of MYCN in neuroblastomas.
E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. (1999)

Disruption of the retinoblastoma (RB) tumor suppressor pathway is a common and important event in breast carcinogenesis. To examine the role of the retinoblastoma protein (pRB) in this process, we created human mammary epithelial cells (HMEC) deficient for pRB by infecting primary outgrowth from breast organoids with the human papillomavirus type 16 (HPV16) E7 gene. HPV16 E7 binds to and inactivates pRB and also causes a significant down-regulation of the protein. Culturing normal HMEC in a reconstituted basement membrane (rBM) provides a correct environment and signaling cues for the formation of differentiated, acini-like structures. When cultured in this rBM, HMEC+E7 were found to respond morphologically as normal HMEC and form acinar structures. In contrast to normal HMEC, many of the cells within the HMEC+E7 structures were not growth arrested, as determined by a 5-bromo-2'-deoxyuridine incorporation assay. pRB deficiency did not affect polarization of these structures, as indicated by the normal localization of the cell-cell adhesion marker E-cadherin and the basal deposition of a collagen IV membrane. However, in HMEC+E7 acini, we were unable to detect by immunofluorescence microscopy the milk protein lactoferrin or cytokeratin 19, both markers of differentiation expressed in the normal HMEC structures. These data suggest that loss of RB in vivo would compromise differentiation, predisposing these cells to future tumor-promoting actions.
Técnicas para mejorar presentaciones en formato electrónico (2009)

Se exponen algunas definiciones y explican procedimientos para el mejoramiento de las presentaciones electronicas, fundamentalmente en docentes e investigadores que la utilizan en su quehacer diario. Se realiza una busqueda bibliografica profunda, para recopilar la mayor cantidad de informacion sobre las tecnicas para mejorarlas y conformar guia para los profesionales, en especial, de salud publica.
Structure of amyloid β fragments in aqueous environments (2005)

Conformational studies on amyloid beta peptide (Abeta) in aqueous solution are complicated by its tendency to aggregate. In this study, we determined the atomic-level structure of Abeta(28-42) in an aqueous environment. We fused fragments of Abeta, residues 10-24 (Abeta(10-24)) or 28-42 (Abeta(28-42)), to three positions in the C-terminal region of ribonuclease HII from a hyperthermophile, Thermococcus kodakaraensis (Tk-RNase HII). We then examined the structural properties in an aqueous environment. The host protein, Tk-RNase HII, is highly stable and the C-terminal region has relatively little interaction with other parts. CD spectroscopy and thermal denaturation experiments demonstrated that the guest amyloidogenic sequences did not affect the overall structure of the Tk-RNase HII. Crystal structure analysis of Tk-RNase HII(1-197)-Abeta(28-42) revealed that Abeta(28-42) forms a beta conformation, whereas the original structure in Tk-RNase HII(1-213) was alpha helix, suggesting beta-structure formation of Abeta(28-42) within full-length Abeta in aqueous solution. Abeta(28-42) enhanced aggregation of the host protein more strongly than Abeta(10-24). These results and other reports suggest that after proteolytic cleavage, the C-terminal region of Abeta adopts a beta conformation in an aqueous environment and induces aggregation, and that the central region of Abeta plays a critical role in fibril formation. This study also indicates that this fusion technique is useful for obtaining structural information with atomic resolution for amyloidogenic peptides in aqueous environments.
A semiconductor lighting system controlled through a LIN network to automotive application (2005)

This paper proposes an intelligent lighting system for bus interior environment using LEDs (light emitting diodes) controlled through an automotive communication network. The system consists on a master central control and slaves lighting modules, using a LIN (local interconnect network) network to perform communication. This network is a low cost alternative to the proposed system requirements, due to its low bit rate and physical needs. The slaves are independent lighting modules that supply a group of LEDs and measure the environment lighting level. The master sets LEDs module parameters (slaves), such as the state (on/off), and desired lighting level The master makes the user interface, sets the lighting parameters, as timer and lighting level and, more over, it establishes communication with other bus systems through a CAN (controller area network) gateway. This paper presents a complete logical description, including block and state diagrams, a physical description and some relevant experimental results.
Enhanced damage in bipolar devices at low dose rates: effects at very low dose rates (1996)

The effect of very low dose rate irradiation is investigated for several linear bipolar devices that are sensitive to enhanced low dose-rate damage, including one device with super-/spl beta/ input transistors. New results are included at 0.001 and 0.002 rad(Si)/s. Irradiations at elevated temperature at high dose rate are compared with room temperature irradiation at very low dose rate. Possible mechanisms for enhanced damage are discussed.
[Replacement of the vertebral body with an expansion implant (Synex)]. (2002)

Synex is a sophisticated implant to replace severely damaged vertebral bodies regardless of the nature of lesion. Its application required additional stabilization by either posterior or anterior fixation (internal transpedicular fixator and Ventrofix or Kaneda, respectively). Its use is indicated in post-traumatic defects of vertebrae in acute or poorly healed scervical.
A system for PCB automated inspection using fluorescent light (1988)

Research was performed on the detection of faults such as shorts, cuts, and nicks in a printed circuit board pattern. The possibility was investigated of detecting a pattern by illuminating a printed circuit board with violet or ultraviolet rays and detecting the pattern using the (yellow or other) fluorescent light emitted by the base material consisting of glass-epoxy or glass-polyimide, etc. It was found that the pattern could be detected clearly by selecting an optical fiber that would separate the emitted fluorescent light from the illumination and using a detector consisting of a high-sensitivity TV camera that produces a silhouette image in which the base material is bright and the pattern is dark. A printed-circuit-board pattern inspector using this approach was developed. Test operation of the inspector in a plant demonstrated that it performs consistently good pattern inspections.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Estimation of low-rank tensors via convex optimization (2010)

In this paper, we propose three approaches for the estimation of the Tucker decomposition of multi-way arrays (tensors) from partial observations. All approaches are formulated as convex minimization problems. Therefore, the minimum is guaranteed to be unique. The proposed approaches can automatically estimate the number of factors (rank) through the optimization. Thus, there is no need to specify the rank beforehand. The key technique we employ is the trace norm regularization, which is a popular approach for the estimation of low-rank matrices. In addition, we propose a simple heuristic to improve the interpretability of the obtained factorization. The advantages and disadvantages of three proposed approaches are demonstrated through numerical experiments on both synthetic and real world datasets. We show that the proposed convex optimization based approaches are more accurate in predictive performance, faster, and more reliable in recovering a known multilinear structure than conventional approaches.
Equivalence checking on ESL utilizing a priori knowledge (2016)

We propose EASY, an algorithm for functional equivalence checking of ESL descriptions written in a high-level programming language like C++. Given two ESL descriptions, in a PDR-like fashion EASY systematically refines a candidate invariant to characterize the reachable states of a miter of the descriptions until either the invariant becomes inductive or a counterexample has been found. The algorithm is flexible and allows to incorporate a priori knowledge about the design to speed up the verification process. We provide an implementation of EASY on top of a standard model checker and show in two case studies that EASY outperforms other state-of-the-art equivalence checking tools.
Colorimetric Polydiacetylene–Aerogel Detector for Volatile Organic Compounds (VOCs) (2016)

A new hybrid system comprising polydiacetylene (PDA), a chromatic conjugated polymer, embedded within aerogel pores has been constructed. The PDA-aerogel powder underwent dramatic color changes in the presence of volatile organic compounds (VOCs), facilitated through infiltration of the gas molecules into the highly porous aerogel matrix and their interactions with the aerogel-embedded PDA units. The PDA-aerogel composite exhibited rapid color/fluorescence response and enhanced signals upon exposure to low VOC concentrations. Encapsulation of PDA derivatives displaying different headgroups within the aerogel produced distinct VOC-dependent color transformations, forming a PDA-aerogel "artificial nose".
Progestins in preventive hormone therapy. Including pharmacology of the new progestins, desogestrel, norgestimate, and gestodene: are there advantages? (1994)

Progestins have played an important role in hormone replacement therapy (HRT). This article reviews the history, structure, and pharmacology of synthetic progestins, including the new progestins, norgestimate, gestodene, and desogestrel. The benefits and potential effect on carcinoma of the breast for each HRT are summarized. Current treatment alternatives are addressed.
Near-Optimal Sparse Recovery in the L1 Norm (2008)

We consider the *approximate sparse recovery problem*, where the goal is to (approximately) recover a high-dimensional vector x from Rn from its lower-dimensional *sketch* Ax from Rm.Specifically, we focus on the sparse recovery problem in the L1 norm: for a parameter k, given the sketch Ax, compute an approximation x' of x such that the L1 approximation error | |x-x'| | is close to minimum of | |x-x*| | over all vectors x* with at most k terms. The sparse recovery problem has been subject to extensive research over the last few years.Many solutions to this problem have been discovered, achieving different trade-offs between various attributes, such as the sketch length, encoding and recovery times.In this paper we provide a sparse recovery scheme which achieves close to optimal performance on virtually all attributes. In particular, this is the first recovery scheme that guarantees k log(n/k) sketch length, and near-linear n log (n/k) recovery time *simultaneously*. It also features low encoding and update times, and is noise-resilient.
Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex (2002)

The response of extracellular dopamine (DA) and its relationship to motivational valence (positive or negative) and novelty of motivational stimuli was investigated by brain microdialysis in the nucleus accumbens (NAc) shell and core and prefrontal cortex (PFCX) of rats. Stimuli were elicited by intraoral infusion of 20% sucrose, sucrose plus chocolate, quinine, and NaCl solutions, feeding of a palatable food (Fonzies), or smelling of a predator (red fox) urine. Sucrose elicited appetitive reactions and increased DA in the PFCX but not in the NAc shell. An unfamiliar appetitive taste such as that of sweet chocolate and Fonzies, increased DA in all three areas. Habituation of the stimulatory DA response to intraoral chocolate or to Fonzies feeding was observed in the NAc shell after a single pre-exposure to the same taste or food; no habituation was observed in the NAc core nor in the PFCX. Aversive taste stimuli (quinine, saturated NaCl solutions) rapidly increased DA in the PFCX and in the NAc core, and this response did not undergo one-trial habituation. In the NAc shell, instead, no effect (10 min exposure) or a delayed, transitory increase of DA (5 min exposure) sensitive to one-trial habituation was obtained in response to the aversive taste (quinine and saturated NaCl) or olfactory (red fox urine) stimuli. These observations indicate that DA responsiveness is an integrated function of the motivational valence and novelty of stimuli in the NAc shell and an expression of generic motivational value in the NAc core and PFCX.
Temperature threshold tuning of a thermal harvesting switch (2009)

This paper presents an original energy harvester making use of a temporal variation of temperature and converting it to electricity. Such a device combines piezoelectric and magnetic materials in order to be able to react to small and slow variations of temperature. Therefore it can be integrated for powering nodes in a wireless sensor network. We report here how to tune the behavior of such generator. By modifying the gap between the hard magnet and the soft magnetic material, it is possible to finely control the hysteresis between the two thresholds but also the position of those thresholds. Finally, like for the electrical load, there is an optimal gap which allows the harvesting of a maximum power.
Low‐Threshold Nanoimprinted Lasers Using Substructured Gratings for Control of Distributed Feedback (2013)

A nanopatterned polymer design for lasers using substructured gratings to achieve low threshold lasing is presented. The approach provides complete control over the balance between optical feedback and output coupling. Polymer lasers are fabricated by nanoimprint lithography with threshold densities as low as 16 W cm‐2, half that of reference distributed feedback lasers with conventional gratings.
Fusion power plant (1974)

disposal of that material difficult. Although the activation in the vanadium is comparable to that in the steel, the short half-lives of the radioisotopes (less than a year) greatly reduce the disposal problems. (auth)
A signal-specific successive-approximation analog-to-digital converter (2011)

This paper presents a modified structure and a new switching algorithm in successive-approximation analog-to-digital converters to reduce the power consumption. This technique is more efficient in applications where the input signal activity is low most of the time such as biomedical signals. For slow-varying samples, only the least significant bits of the new analog sample are extracted leading to power saving in both the capacitor-based DAC and the comparator. For an Electrocardiogram signal and with the proposed structure, the simulated power consumption of the DAC, the comparator and the entire ADC for an 8-bit 1-kS/s converter are 75%, 43% and 50% smaller than those of a conventional architecture, respectively.
Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise (2003)

The hypothesis that fatigue during prolonged exercise arises from insufficient intramuscular glycogen, which limits tricarboxylic acid cycle (TCA) activity due to reduced TCA cycle intermediates (TCAI), was tested in this experiment. Seven endurance-trained men cycled at approximately 70% of peak O(2) uptake (Vo(2 peak)) until exhaustion with low (LG) or high (HG) preexercise intramuscular glycogen content. Muscle glycogen content was lower (P < 0.05) at fatigue than at rest in both trials. However, the increase in the sum of four measured TCAI (>70% of the total TCAI pool) from rest to 15 min of exercise was not different between trials, and TCAI content was similar after 103 +/- 15 min of exercise (2.62 +/- 0.31 and 2.59 +/- 0.28 mmol/kg dry wt for LG and HG, respectively), which was the point of volitional fatigue during LG. Subjects cycled for an additional 52 +/- 9 min during HG, and although glycogen was markedly reduced (P < 0.05) during this period, no further change in the TCAI pool was observed, thus demonstrating a clear dissociation between exercise duration and the size of the TCAI pool. Neither the total adenine nucleotide pool (TAN = ATP + ADP + AMP) nor IMP was altered compared with rest in either trial, whereas creatine phosphate levels were not different when values measured at fatigue were compared with those measured after 15 min of exercise. These data demonstrate that altered glycogen availability neither compromises TCAI pool expansion nor affects the TAN pool or creatine phosphate or IMP content during prolonged exercise to fatigue. Therefore, our data do not support the concept that a decrease in muscle TCAI during prolonged exercise in humans compromises aerobic energy provision or is the cause of fatigue.
Robust video fingerprinting based on 2D-OPCA of affine covariant regions (2008)

This paper proposes a robust video fingerprinting method based on 2-Dimensional Oriented Principal Component Analysis (2D-OPCA) of affine covariant regions. The goal of video fingerprinting is to identify a video clip using perceptual features called fingerprints. In the proposed method, to achieve the robustness against geometric transformations, fingerprints are extracted from local regions co-variant with a class of affine transformations. The detected affine covariant regions are normalized geometrically and photometrically, and local fingerprints are extracted by applying a novel discriminant analysis algorithm, 2D-OPCA to the normalized regions. For the reliable matching of local fingerprints, only spatio-temporally consistent matches are taken into account. The experimental results show that the proposed method is robust against both geometric and non-geometric transformations.
On span programs (2002)

A linear algebraic model of computation the span program, is introduced, and several upper and lower bounds on it are proved. These results yield applications in complexity and cryptography. The proof of the main connection, between span programs and counting branching programs, uses a variant of Razborov's general approximation method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Evidence for a role of adaptive immune response in the disease pathogenesis of the<scp>MPTP</scp>mouse model of Parkinson's disease (2015)

Parkinson's disease (PD) is the second most common neurodegenerative disease and results from the loss of dopaminergic neurons of the nigrostriatal pathway. The pathogenesis of PD is poorly understood, but inflammatory processes have been implicated. Indeed increases in the number of major histocompatibility complex II (MHC II) reactive cells have long been recognised in the brains of PD patients at post-mortem. However whether cells expressing MHC II play an active role in PD pathogenesis has not been delineated. This was addressed utilising a transgenic mouse null for MHC II and the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In wild-type mice MHC II levels in the ventral midbrain were upregulated 1-2 days after MPTP treatment and MHC II was localized in both astrocytes and microglia. MHC II null mice showed significant reductions in MPTP-induced dopaminergic neuron loss and a significantly reduced invasion of astrocytes and microglia in MHC II null mice receiving MPTP compared with controls. In addition, MHC II null mice failed to show increases in interferon-γ or tumour necrosis factor-α in the brain after MPTP treatment, as was found in wild-type mice. However, interleukin-1β was significantly increased in both wild-type and MHC II null mice. These data indicate that in addition to microglial cell/myeloid cell activation MHC Class II-mediated T cell activation is required for the full expression of pathology in this model of PD.