gebhart/patrepeval huggingface dataset:
Elevated serum progesterone on the day of HCG administration in IVF is associated with a higher pregnancy rate in polycystic ovary syndrome (1999)

Our study compared 84 patients with polycystic ovary syndrome (PCOS) with 84 control patients who had normal ovaries and who were matched for the main determinants of success in in-vitro fertilization (IVF) and embryo transfer. Serum concentrations of oestradiol and progesterone on the day of human chorionic gonadotrophin (HCG) injection were significantly higher in PCOS than in normal patients (oestradiol 2016 +/- 1.8 pg/ml versus 1456 +/- 40.9 pg/ml, P < 0.01; progesterone 1.6 +/- 0.1 ng/ml versus 1.2 +/- 0.1 ng/ml, P = 0.03). Furthermore despite oocytes from PCOS patients having a reduced fertilization rate compared with normal patients (61.8 +/- 4.1% versus 73.5 +/- 4.3%, P = 0.03), the differences in pregnancy rate (22.6 versus 19%) and miscarriage (31.5 versus 18.7%) were not statistically significant. In PCOS patients, a critical breakpoint was identified at serum progesterone concentrations of 1.2 ng/ml on the day of HCG injection. The PCOS patients with progesterone > or = 1.2 ng/ml showed a higher pregnancy and miscarriage rate than PCOS patients with progesterone < 1.2 ng/ml (26.6 versus 17.9%, P < 0.01; and 41.7% versus 14.3%, P < 0.01 respectively). These findings suggest that premature progesterone production does not have an adverse effect on pregnancy rate in PCOS, but on the contrary, may be a predictor for success in IVF/embryo transfer.
Anisotropic defect structure and transport properties of YBa2Cu3O7−δ films on vicinal SrTiO3(001) (1999)

The microstructure of YBa2Cu3O7−δ thin films grown on vicinal SrTiO3(001) has been studied as a function of the vicinal angle by x-ray diffraction using the two-dimensional q-scan technique. Our results reveal a strong correlation between the miscut of a SrTiO3(001) substrate and the anisotropic defect structure of the film. Furthermore, we observed an anisotropy of the corresponding critical current density up to 4.6 depending on the angle of miscut.
Increasing role of herpes simplex virus type 1 in first-episode anogenital herpes in heterosexual women and younger men who have sex with men, 1992-2006 (2009)

The proportion of first-episode anogenital herpes due to HSV-1 significantly increased among younger MSM and heterosexual women over the 15-year period. In some clinical populations, such as young MSM and women or patients with anal disease, HSV-1 may now account for the majority of first-episode anogenital herpes.
On the synchronizability and detectability of random PPM sequences (1989)

The problem of synchronization and detection of random pulse-position modulation (PPM) sequences is investigated under the assumption of perfect slot synchronization. Maximum-likelihood PPM symbol synchronization and receiver algorithms are derived that make decisions based on both soft and hard data; these algorithms are seen to be easily implementable. The author derives bounds on the symbol error probability and the probability of false synchronization that indicate the existence of a severe performance floor, which can be the limiting factor in the overall system performance. The performance floor is inherent in the PPM format and random data and becomes more serious as the PPM alphabet size Q is increased. A way to eliminate the performance floor is suggested by inserting 'special' PPM symbols in the random data stream.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014 (2015)

Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of MERS-CoV.
Honeypots: practical means to validate malicious fault assumptions practical experience report (2004)

We report on an experiment run with several honeypots for 4 months. The motivation of this work resides in our wish to use data collected by honeypots to validate fault assumptions required when designing intrusion-tolerant systems. This work in progress establishes the foundations for a feasibility study into that direction. After a review of the state of the art with respect to honeypots, we present our test bed, discuss results obtained and lessons learned. Avenues for future work are also proposed.
V/STOL Aircraft Noise Prediction (Jet Propulsors) (1975)

A computer program is presented for predicting the noise levels of V/ STOL aircraft with jet-propulsive-lift systems. Using the equations developed in Part I of this report the noise levels may also be estimated with hand calculations. Vectored thrust, externally blown flap, upper surface blown flap, internally blown flap, and augmentor wing are the propulsive-lift concepts considered. Semi-empirical equations are derived using the test results and theories for the following aircraft noise sources: Internal engine, jet, excess (core engine), high-lift system, airframe, and auxiliary power unit. The computer program predicts the perceived noise levels and tone corrected perceived noise levels for V/STOL aircraft at any specified sideline distance for known geometrical and operational parameters. This report supersedes the earlier report No. FAA-RD-73-145, August 1973.
The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease (2011)

Huntington disease (HD) is a dominantly inherited neurodegenerative disorder that results from expansion of the polyglutamine repeat in the huntingtin (HTT) gene. There are currently no effective treatments for this devastating disease. Given its monogenic nature, disease modification therapies for HD should be theoretically feasible. Currently, pharmacological therapies aimed at disease modification by altering levels of HTT protein are in late-stage preclinical development. Here, we review current efforts to develop new treatments for HD based on our current understanding of HTT function and the main pathological mechanisms. We emphasize the need to enhance translational efforts and highlight the importance of aligning the clinical and basic research communities to validate existing hypotheses in clinical studies. Human and animal therapeutic trials are presented with an emphasis on cellular and molecular mechanisms relevant to disease progression.
Simulation of bubbles (2006)

We present a novel framework based on a continuous fluid simulator for general simulation of realistic bubbles, with which we can handle as many significant dynamic bubble effects as possible. To capture nature of the very thin liquid film of bubbles, we have developed a regional level set method allowing multi-manifold interface tracking. The regional level set method is based on the definitions of regional distance and its five operators, which makes it very easy to implement. We can reconstruct an implicit surface of liquid film with arbitrary thickness from the representation of regional level set functions. To overcome the numerical instability caused by surface tension, we exploit a new semi-implicit surface tension model which is unconditionally stable and makes the simulation of surface tension dominated phenomena much more efficient. An approximated film thickness evolution model is proposed to control the bubble's lifecycle. All these new techniques combine into a general framework that can produce various realistic dynamic effects of bubbles.
The <i>dare</i> gene: steroid hormone production, olfactory behavior, and neural degeneration in <i>Drosophila</i> (1999)

Steroid hormones mediate a wide variety of developmental and physiological events in insects, yet little is known about the genetics of insect steroid hormone biosynthesis. Here we describe the Drosophila dare gene, which encodes adrenodoxin reductase (AR). In mammals, AR plays a key role in the synthesis of all steroid hormones. Null mutants of dare undergo developmental arrest during the second larval instar or at the second larval molt, and dare mutants of intermediate severity are delayed in pupariation. These defects are rescued to a high degree by feeding mutant larvae the insect steroid hormone 20-hydroxyecdysone. These data, together with the abundant expression of dare in the two principal steroid biosynthetic tissues, the ring gland and the ovary, argue strongly for a role of dare in steroid hormone production. dare is the first Drosophila gene shown to encode a defined component of the steroid hormone biosynthetic cascade and therefore provides a new tool for the analysis of steroid hormone function. We have explored its role in the adult nervous system and found two striking phenotypes not previously described in mutants affected in steroid hormone signaling. First, we show that mild reductions of dare expression cause abnormal behavioral responses to olfactory stimuli, indicating a requirement for dare in sensory behavior. Then we show that dare mutations of intermediate strength result in rapid, widespread degeneration of the adult nervous system.
Surviving breast cancer: a problematic work re-entry. (1994)

This article presents a paradigm case of a problematic work re-entry experience of a breast cancer survivor (Kathy). The case was drawn from a qualitative descriptive study of 25 long-term survivors of breast cancer. The study describes the lived experience and practical "know how" of survivors. Study participants completed three in-depth process interviews that were transcribed and analyzed for common themes. The paradigm case presented here is one of five paradigms that emerged from the data. The case demonstrates the profound impact of a negative work re-entry experience on a cancer survivor's reformulating sense of self. In addition to pericarditis and lymphedema, Kathy experienced long-term emotional distress. Although work provided a primary source of meaning, Kathy ultimately gave up her desire to return to work. Predominant features of the case include: a breach of confidentiality of medical information in the work setting; absence of resources and support to assist with work re-entry and the management of social stigma; difficulty in talking with colleagues and others about her health; and difficulty in asking for and receiving assistance. The understandings set forth from Kathy's experience can guide clinicians to explore the meaning of work in the lives of their patients and can encourage the development and use of work re-entry programs.
Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors (2006)

Osteogenic potentials of some recombinant human bone morphogenetic protein (BMP) first-generation adenoviral vectors (ADhBMPs) are significantly limited in immunocompetent animals. It is unclear what role expression of viral proteins and foreign proteins transduced by adenoviral vectors play in the host immune response and in ectopic bone formation. In this study two sets of experiments were designed and performed. First, rat BMP6 cDNA were amplified, sequenced, and recombined in first-generation adenoviral vector (ADrBMP6). A comparison of human and rat BMP6 adenoviral vectors demonstrated identical osteogenic activities in both immunodeficient and immunocompetent rats. Second, the activities of recombinant human BMP6 in E1- (ADhBMP6) and [E1-,E2b-] ( [E1-,E2b-]ADGFP&hBMP6, and [E1-,E2b-]ADhBMP6) adenoviral vectors were compared in both in vitro and in vivo models. Similar activities of these two generations of BMP adenoviral vectors were found in all models. These results indicate that the amount of viral gene expression and the source of the BMP cDNA are not major factors in the interruption of osteogenic potentials of recombinant BMP6 adenoviral vectors in immunocompetent animals.
Typography on the Web (1998)

From the Publisher:
Now you can publish perfect Web pages using typefaces that you can provide to your Web site visitors. This comprehensive book for webmasters and other Web workers on the new Web typography begins with a few chapters for those who missed Desktop Publishing 101 and quickly moves on to provide the groundwork for understanding the new typesetting and layout enabled by Cascading Style Sheets (CSS), TrueDoc, and font embedding. Two chapters make using CSS easy by featuring hands-on work with CSS as well as a handy reference, and other chapters help you master TrueDoc typesetting and font embedding. The book also explores dozens of ideas for typography using only HTML and covers specialized Web pages such as for NetTV (e.g., WebTV), Java, and cross-media publishing.
High Temperature Properties of a Single Crystal Superalloy PWA1484 Directly Recycled After Turbine Blade Use (2016)

This chapter contains sections titled: Introduction Test Material Preparation High Temperature Property Tests Results and Discussions Conclusion Acknowladgements
Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis (2014)

Probiotics are effective treatments for IBS, although which individual species and strains are the most beneficial remains unclear. Further evidence is required before the role of prebiotics or synbiotics in IBS is known. The efficacy of all three therapies in CIC is also uncertain.
No. II.-REPORT ON THE ECHINODERMA (OTHER THAN HOLOTHURIANS) COLLECTED BY Mr. J. STANLEY GARDINER IN THE WESTERN PARTS OF THE INDIAN OCEAN. (1909)

No. II.—Report on the Echinoderma (Other than Holothurians) Collected by Mr. J. Stanley Gardiner in the Western Parts of the Indian Ocean Get access F. Jeffrey Bell, M.A. F. Jeffrey Bell, M.A. Emeritus Professor and Fellow of King's College 1University of London Search for other works by this author on: Oxford Academic Google Scholar Transactions of the Linnean Society of London. 2nd Series. Zoology, Volume 13, Issue 1, October 1909, Pages 17–22, https://doi.org/10.1111/j.1096-3642.1909.tb00406.x Published: 09 April 2009
Molecular Analysis of Growth Inhibition Caused by Overexpression of the Biotin Operon in<i>Escherichia coli</i> (1995)

Constitutive overexpression of the biotin operon (type 9 mutation) in a multicopy plasmid resulted in growth inhibition in Escherichia coli. Deletion analysis of the biotin operon indicated that overexpression of the bioB gene alone, the product of which is believed to catalyze the conversion of dethiobiotin to biotin, is sufficient for growth inhibition. This growth inhibition was still observed when the wild-type bioB gene was replaced by several mutant-type bioB genes derived from biotin auxotrophs that have base-pair substitutions creating amino acid substitutions in the bioB gene product. However, the modification of Ala 143 and Gly 99 of the bioB gene product resulted in recovery from growth inhibition. These results suggest that this phenotype of growth inhibition by overexpression of the bioB gene in E. coli is independent of the biotin-forming activity itself, but is caused by some function involving a specific conformation of the bioB gene product.
Molecular and biochemical characterisation of Mycobacterium smegmatis alcohol dehydrogenase C (2001)

The gene encoding of an alcohol dehydrogenase C (ADHC) from Mycobacterium smegmatis was cloned and sequenced. The protein encoded by this gene has 78% identity with Mycobacterium tuberculosis and Mycobacterium bovis BCG ADHC. The M. smegmatis ADHC was purified from M. smegmatis and the kinetic parameters of this enzyme showed that using NADPH as electron donor it has a strong preference for aliphatic and aromatic aldehyde substrates. Like the M. bovis BCG ADHC, this enzyme is more likely to act as an aldehyde reductase than as an alcohol dehydrogenase. The discovery of such an ADHC in a fast-growing, and easily engineered mycobacterial species opens the way to the utilisation of this M. smegmatis enzyme as a convenient model for the study of the physiological role of this alcohol dehydrogenase in mycobacteria. © 2001 Federation of European Microbiological Societies.
A low-power and high-gain converter for driving dielectric elastomer actuators (2013)

Dielectric elastomers are being used as actuators to convert electrical energy to mechanical deformation in a wide variety of potential microrobotic applications. Majority of these actuators are being excited using external bulky power supplies, which limit the functionality of the actuator. One of the major challenges towards enabling operation of these applications without an external power source is development of lightweight and high power density power electronic interfaces (PEI) with very high step-up gains. This manuscript proposes a special circuit topology to drive dielectric elastomers. The experimental validation has been carried out to verify ability of the circuit to drive a 600V dielectric elastomer at 4Hz for microrobotic applications.
Causal chain approaches to the evaluation of highway safety countermeasures (1971)

THE PROCESS OF EVALUATION OF HIGHWAY SAFETY COUNTERMEASURES IS EXAMINED FROM TWO POINTS OF VIEW-EVALUATION AT THE PROJECT PLANNING STAGE IN WHICH COST-EFFECTIVENESS ANALYSIS IS APPROPRIATE AND EVALUATION AFTER IMPLEMENTATION USING THE TECHNIQUES OF EXPERIMENTAL DESIGN AND STATISTICAL ANALYSIS. THE USE OF A CASUAL CHAIN APPROACH TO EVALUATION OF HIGHWAY SAFETY COUNTERMEASURES IS RECOMMENDED. IN THIS APPROACH MEASUREMENTS OF THE DIRECT EFFECTS OF A COUNTERMEASURE ARE MADE, AND THESE ARE RELATED TO THE ULTIMATE (ACCIDENT) MEASURE BY ANALYZING THE CHAIN OF EVENTS WHICH FOLLOW. THREE EXAMPLES OF THIS TECHNIQUE ARE GIVEN - ONE INVOLVING A SPEED CONTROL PROGRAM PROMOTED BY A POLICE AGENCY, A SECOND INVOLVING A MOTOR VEHICLE INSPECTION PROGRAM, AND THE THIRD AN IMPROVED AMBULANCE SYSTEM. THE CAUSAL CHAIN APPROACH CAN YIELD RATHER IMMEDIATE AND USEFUL RESULTS. WHILE THESE MEASURES MAY NOT BE POLITICALLY AS SATISFYING AS DRAMATIC LIFE-SAVING CLAIMS, THEY HAVE THE VIRTUE OF BEING MORE REALISTIC INDICATORS OF THE SUCCESS OF A COUNTERMEASURE PROGRAM. /AUTHOR/
Rhythm Analysis Using Vectorcardiograms (1985)

Fourier shape descriptors of vectorcardiograms have been proposed for cardiac rhythm analysis. The technique characterizes the differences in shape and size of the normal and abnormal vectorcardiograms. The specific abnormalities considered are premature ventricular contractions (PVC's) and supraventricular premature contractions (SVPC's).
Handwritten Word Spotting with Corrected Attributes (2013)

We propose an approach to multi-writer word spotting, where the goal is to find a query word in a dataset comprised of document images. We propose an attributes-based approach that leads to a low-dimensional, fixed-length representation of the word images that is fast to compute and, especially, fast to compare. This approach naturally leads to an unified representation of word images and strings, which seamlessly allows one to indistinctly perform query-by-example, where the query is an image, and query-by-string, where the query is a string. We also propose a calibration scheme to correct the attributes scores based on Canonical Correlation Analysis that greatly improves the results on a challenging dataset. We test our approach on two public datasets showing state-of-the-art results.
Cell-specific Activation of the Atrial Natriuretic Factor Promoter by PITX2 and MEF2A (2004)

The PITX2 homeodomain protein is mutated in patients with Axenfeld-Rieger syndrome and is involved in the development of multiple organ systems, including the heart. We have examined the interaction of PITX2 isoforms with myocyte-enhancing factor 2A (MEF2A), which is a known regulator of cardiac development. A direct interaction between PITX2a and MEF2A was demonstrated using yeast two-hybrid and GST pull-down assays. To study the functional significance of this interaction, we used the atrial natriuretic factor (ANF) promoter. Coexpression of MEF2A and PITX2a or Pitx2c resulted in a strong synergistic activation of the ANF promoter in LS8 oral epithelial cells but not in other cell lines (NIH/3T3, Chinese hamster ovary, or C2C12). The synergism was dependent on promoter context, because it required MEF2 binding sites and was not seen with two other PITX2 target promoters. DNA binding by MEF2A was required but not sufficient for synergism. Upstream activators of p38 MAP kinases, MKK3 and MKK6, increased PITX2a and Pitx2c activity to yield up to 90-fold activation of the ANF promoter in LS8 cells. Because Axenfeld-Rieger syndrome is autosomal dominant and affects development of the oral epithelium, we tested one of the known PITX2 mutants. The PITX2a-K88E mutant protein suppressed wild type PITX2a synergism with MEF2A. These results demonstrate a promoter- and cell-specific functional interaction between PITX2 and MEF2A and suggest the possibility of coordinate control by these factors in the oral epithelium.
Oxygen Consumption in Skin of Experimentally Burned Rats (1969)

Burns of approximately 15% of body area were inflicted on three series of white male rats. Time-temperature combinations were employed which produced leasions resembling a superficial second degree, a deep second degree and a third degree burn respectively.Oxygen consumption was measured by Warburg technique in burned and unburned skin at intervals of one hour, one week and two weeks post-burn.In a small number of animals oxygen consumption was studied in superficial parts of skin. In most animals deep parts (including some dermal tissue and panniculus carnousus) were examined by the same technique. Oxygen consumption was higher in the deep parts of skin.In the deep parts oxygen consumption one hour postburn was depressed sharply in the deep second degree burn (90°C for 5 sec) and zero in the third degree (90°C for 20 sec). However, it was increased in the superficial second (70°C for 5 sec). This may be due to qualitative changes caused by increased vascularity or to changes in the tissue mediated by products released in burned tissue. Increase in leucocytes in traumatized tissue might also bring about such a change.Values at one and two weeks were consistent with regeneration in the deep second degree and with necrosis in the third degree burn.Unburned tissue in all series of burned animals showed early depression of values which continued throughout the first week, and were returning towards preburn levels at two weeks.A method of excising corium which markedly reduces bacterial contamination is described. This method is simple and produces reproducable results.