gebhart/patrepeval huggingface dataset:
Model driven development of data warehouses (2006)

Long lasting and heavyweight data warehouse development processes may be far more automated using set of standard schema and data transformations based on relevant conceptual models. Model-driven method for development of data warehouses is proposed based on primary concept model and warehouse concept model. The primary concept model treats object types and their properties as individual concepts and enables direct conversion to warehouse schema; it may be easily extracted from normalized relational schema of database. The concept model enables to get warehouse schema in multi-dimensional normal form that ensures avoiding of aggregation anomalies. It suggests extracting of operational data to warehouse in their original fine-grained form thus allowing flexibility of queries. Transformations between primary concept model and warehouse concept model enable automatic or semi-automatic development of warehouse schema. Important issue from this research is in the fact that normalization of operational databases not only secures from update anomalies but also makes it possible to easy using of operational data in warehousing
Nonvolatile Configuration Memory Cell for Low Power Field Programmable Gate Array (2011)

A new FPGA design using nonvolatile configuration memory (NCM) has been presented. NCM with large On/Off resistance ratio, such as nanoionic memory, is adopted to replace SRAM-based configuration memory. Since NCM is fabricated between interconnect layers of CMOS, silicon area is smaller than in the case of SRAM. Unlike previous FPGAs with nonvolatile programmable wires, we took architecture based approach for designing memory cell, since the cell area of programmable wire cell becomes larger than conventional SRAM-based configuration memory. We designed high-density NCM layout to evaluate the area reduction of configuration memory and verified the area of NCM is about 3.8X smaller than that of SRAM-based configuration memory, while it is 19X larger in the case of the programmable wire than SRAM-based one. It is expected that NCM achieved about over 20% reduction in total FPGA area. Area reduction of configuration memory also shortens the interconnect length to reduce the interconnect delay. Furthermore, nonvolatility achieves low power consumption with power gating.
Variable Response to Probiotics in Two Models of Experimental Colitis in Rats (2002)

Both VSL#3 and LGG significantly ameliorated colitis induced by the sulfhydryl-blocker iodoacetamide, but had no effect on the immune-mediated DNBS-induced colitis. The results suggest a possible role for sulfhydryl compounds in the protective effect of probiotic bacteria, and support their use in patients with inflammatory bowel disease.
Immune-related adverse events associated with immune check-point inhibitors (2019)

Inhibitory kontrolnĂ­ch bodĹŻ (ICIs) jsou monoklonĂĄlnĂ­ protilĂĄtky s imunomodulaÄnĂ­m ĂşÄinkem, kterĂŠ blokujĂ­ brzdnĂŠ mechanismy aktivace T bunÄk. LĂŠÄba ICIs je schvĂĄlena k terapii Ĺady nĂĄdorovĂ˝ch onemocnÄnĂ­ a u ÄĂĄsti pacientĹŻ byla prokĂĄzĂĄna signifikantnÄ lepĹĄĂ­ odpovÄÄ na lĂŠÄbu a delĹĄĂ­ pĹeĹžitĂ­. Tato terapie vede k upregulaci imunitnĂ­ho systĂŠmu s vĂ˝slednĂ˝m efektem na protinĂĄdorovou imunitu. DĹŻsledkem je i rozvoj imunitnÄ podmĂ­nÄnĂ˝ch neĹžĂĄdoucĂ­ch ĂşÄinkĹŻ (irAE), kterĂŠ jsou pomÄrnÄ ÄastĂŠ, mohou postihnout jeden nebo vĂ­ce orgĂĄnĹŻ a mohou bĂ˝t i Ĺživot ohroĹžujĂ­cĂ­. PĂŠÄe o pacienta s irAE je komplexnĂ­ a vyĹžaduje multidisciplinĂĄrnĂ­ pĹĂ­stup k zajiĹĄtÄnĂ­ rychlĂŠ diagnĂłzy irAE a optimĂĄlnĂ­ lĂŠÄby. V ÄlĂĄnku jsou struÄnÄ shrnuty nejÄastÄjĹĄĂ­ a nejzĂĄvaĹžnÄjĹĄĂ­ neĹžĂĄdoucĂ­ ĂşÄinky ICIs a jejich lĂŠÄba.
Relationship between Muscle Activity of the Frontalis and the Associated Brow Displacement (1999)

Although the relationship between regional facial muscle activity and resultant displacement of the face is important to the refinement of many of the treatments of facial paralysis and palsy, this relationship has not been adequately explored. We analyzed the relationship between frontalis muscle activity as measured with surface electromyography and the associated eyebrow displacement as measured with the maximal static response assay in 16 human volunteers. We hypothesized that graded, sustained muscle activity would correlate with graded, sustained elevation of the eyebrow. We found that (1) the relationship between the muscle activity and the corresponding displacements was best described by activity versus displacement squared (r2 = 0.993); (2) there was a wide variation between individual brows for the relationship between muscle activity and displacement; (3) there was a normal amount of asymmetry of the relationship between muscle activity and displacement between the two brows of a subject; (4) left and right frontalis generated the same amount of muscle activity, but left brows elevated significantly higher; (5) the method of simultaneous measurement of muscle activity and displacement used in this study yielded results similar to those previously reported; and (6) the methods used in this study are useful to further investigate the relationship between muscle activity and displacement.
The Kramers–Kronig receiver: a coherent receiver based on intensity detection and phase recovery (2018)

We review the operation principles and the various implementations of the Kramers–Kronig receiver. We show that this scheme allows reconstructing the complex-valued optical field impinging upon the receiver by means of intensity detection and digital phase retrieval.
Interaction Between Mivacurium and Succinylcholine (1995)

We investigated the interaction between mivacurium and succinylcholine when mivacurium was administered during the early recovery from succinylcholine block.We studied 40 adult patients during propofolalfentanil-N2 O-O2 anesthesia. Neuromuscular function was monitored using an electromyographic method (Relaxograph Registered Trademark; Datex, Helsinki, Finland). Patients randomly received either 1.0 mg/kg of succinylcholine followed by 0.15 mg/kg of mivacurium when the first twitch (T1) during succinylcholine block recovered to 5%, or 0.15 mg/kg of mivacurium without succinylcholine. Serum cholinesterase activity was lower than normal range in two patients and higher than normal range in four patients, but the dibucaine number value was normal in every patient. The mean onset time (3.8 +/- 0.9 min) (mean +/- SD) or maximal neuromuscular block (96.6% +/- 7.2%) of mivacurium did not differ between the groups. The T1 recovery times of mivacurium were slightly shorter (P < 0.05) after succinylcholine administration than without it. During recovery of mivacurium block, the fade was significantly greater, i.e., the train-of-four (TOF) ratio was lower, after succinylcholine administration than without it. Recovery index (T1 25%-75%, mean 4.7 +/- 1.3 min) and the time from the administration of mivacurium to the recovery of TOF ratio 0.7 (mean 20.4 +/- 5.1 min) were not different between the groups. In conclusion, in healthy patients succinylcholine has negligible effects on a subsequent mivacurium-induced neuromuscular block. (Anesth Analg 1995;80:534-7)
Conservation of the gene encoding streptococcal antigen I/II in oral streptococci (1991)

The spaP gene of Streptococcus mutans serotype c encodes a major cell surface protein, streptococcal antigen (SA) I/II, with an Mr of 185,000, that is thought to be involved in bacterial adhesion to teeth. Proteins with significant amino acid sequence homology to SA I/II have also been found in S. sobrinus and S. sanguis. The objectives of this study were to investigate the conservation of the spaP gene in the mutans groups of streptococci and to determine whether homologous genes were present in other species of alpha-hemolytic streptococci. DNA extracted from representative strains of 19 streptococcal species was examined by Southern hybridization and partial DNA sequence analysis. A series of five overlapping DNA probes from the spaP gene were amplified by the polymerase chain reaction and used in the Southern hybridizations. The entire gene was found to be well conserved in all strains of S. mutans serotypes c, e, and f investigated. A probe from the 3' region of the gene, which encodes residues 857 to 1207 of the SA I/II protein, hybridized with DNA from a number of mutans streptococci, as well as with DNA from nonmutans alpha-hemolytic streptococci. Conservation within this region was further demonstrated by sequencing gene fragments of two strains of S. intermedius and S. oralis. The results show that some regions of the spaP gene are highly conserved not only in the mutans group of streptococci but also in other nonmutans alpha-hemolytic streptococci. This suggests that a family of cell surface proteins which, by analogy with the 185,000-Mr SA I/II of S. mutans, could be involved in bacterial adhesion might exist.
New statistical methods for analyzing proteomics data from affinity isolation LC-MS/MS experiments (2007)

The field of proteomics is exploding with statistical problems waiting to be explored. To obtain information on protein complexes, interactions between protein pairs is initially examined. This exploration is performed using `bait-prey' pro- tein pull-down assays that use a protein affnity agent and an LC-MS/MS (liquid chromatography-tandem mass-spectrometry)-based protein identifcation method. An experiment generates a protein association matrix wherein each column represents a sample from one bait protein, each row represents one prey protein and each cell contains a presence/absence association indicator. The prey protein presence/absence pattern is assessed with a Likelihood Ratio Test (LRT) and simulated LRT p-values. Fisher's Exact Test and a conditional frequency distribution test using generating functions are also used to assess the prey protein observation pattern. Based on the p-value, each prey protein is assigned a category (Specific or Non-Specific) and appraised with respect to the goal and design of the experiment. The Bayes' Odds is calculated for each prey-bait pair in the `Specific' category to estimate the posterior probability that two proteins interact and compared to an approach used by Gilchrist et al. [23].
A micro‐volume electron capture detector for use in high resolution capillary column gas chromatography (1983)

Abstract A new design for an electron capture detector cell is described. The cell is compatible with the requirements of high resolution capillary columns and is shown to be useful in applications that require high analysis speed. A unique method of sample introduction reduces the problems of sample loss by adsorption on the surfaces of the cell. Previously reported problems of sample loss by adsorption on active surfaces within the cell when using hydrogen carrier gas are shown to have been eliminated. Examples are shown demonstrating the increased speed of analysis that can be obtained when using hydrogen carrier gas and 100 micron diameter columns.
Amorphous Fe-B-Si magnetic films by reactive sputtering from a pure iron source (1988)

The author has successfully used reactive sputtering to fabricate amorphous magnetic thin films with chemical and physical properties similar to those of Metglas■. The sputtering target was commercially available mild steel. The amount of each metalloid in the deposited thin film was controlled by varying the partial pressures of silane and diborane in the sputtering plasma. Total metalloid concentrations were varied over the range of 0–50 at. %. A sample containing 76% Fe:16.5% B:3% Si:3% C was found to be amorphous and to have good soft magnetic properties. This sample had a well-defined uniaxial anisotropy in the plane of the film with an easy axis coercivity of 4.5 Oe. The rf permeability (μ′) of this 2000-Å-thick sample was greater than 1000 from 0 to 900 MHz.
Photonic Integrated Circuits for Radio-Frequency Signal Generation (2015)

This paper reviews the current state of the art of photonic-enabled generation of radio-frequency signals with frequencies within the millimeter wave range (30 to 300 GHz) and above using photonic-integrated circuits (RF-PICs). One of the most important applications to date is the generation of carrier wave frequencies for ultrabroadband wireless communications systems, with data rates up to 100 Gb/s. Among the different photonic signal generation techniques that are available, we focus on the approaches for which photonic integrated solutions have been explored. Optical heterodyning is first presented, based on achieving the integration of a dual wavelength sources. The second approach is through onchip integrated mode locked lasers, with excellent performance in terms of frequency stable, low phase-noise narrow linewidth sources. We review the different laser structures that have been reported, to support the advantages of the new structures that we propose.
Clinical Heterogeneity of Involutional Osteoporosis: Implications for Preventive Therapy* (1990)

Journal Article Clinical Heterogeneity of Involutional Osteoporosis: Implications for Preventive Therapy Get access B. LAWRENCE RIGGS, B. LAWRENCE RIGGS 1Division of Endocrinology, Metabolism, and Internal Medicine (B.L.R.) and the Section of Clinical Epidemiology (L.J.M.), Mayo Clinic and Mayo Foundation, Rochester Rochester, Minnesota 55905 Search for other works by this author on: Oxford Academic Google Scholar L. JOSEPH MELTON, III L. JOSEPH MELTON, III 1Division of Endocrinology, Metabolism, and Internal Medicine (B.L.R.) and the Section of Clinical Epidemiology (L.J.M.), Mayo Clinic and Mayo Foundation, Rochester Rochester, Minnesota 55905 Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 70, Issue 5, 1 May 1990, Pages 1229–1232, https://doi.org/10.1210/jcem-70-5-1229 Published: 01 May 1990 Article history Received: 20 January 1990 Published: 01 May 1990
Basics of glasses (2012)

A glass is a system that does not reach thermodynamic equilibrium during any reasonable experimental time. Therefore, the traditional well-established statistical mechanics methods cannot be applied to such systems. In particular, two concepts that are fundamental to statistical mechanics, namely, ergodicity and the fluctuation-dissipation theorem, cannot be utilized in discussing properties of glasses. This chapter will discuss in more detail the problems inherent in applying these two concepts to glasses and will outline some more of the basic properties of glassy systems. Among glasses, spin glasses are the most similar to electron glasses so their main properties and proposed models will be reviewed. The chapter ends with an introduction to two-level systems, which is suggested as the possible origin of some of the properties of glasses, in particular, those of electron glasses.
Remodeling Epithelial Cell Organization: Transitions Between Front-Rear and Apical-Basal Polarity (2009)

Polarized epithelial cells have a distinctive apical-basal axis of polarity for vectorial transport of ions and solutes across the epithelium. In contrast, migratory mesenchymal cells have a front-rear axis of polarity. During development, mesenchymal cells convert to epithelia by coalescing into aggregates that undergo epithelial differentiation. Signaling networks and protein complexes comprising Rho family GTPases, polarity complexes (Crumbs, PAR, and Scribble), and their downstream effectors, including the cytoskeleton and the endocytic and exocytic vesicle trafficking pathways, together regulate the distributions of plasma membrane and cytoskeletal proteins between front-rear and apical-basal polarity. The challenge is to understand how these regulators and effectors are adapted to regulate symmetry breaking processes that generate cell polarities that are specialized for different cellular activities and functions.
Growth and Characterization of a Porous Aluminum Oxide Film Formed on an Electrically Insulating Support (2003)

Thin films of porous anodic aluminum oxide have been prepared on an electrically insulating support by the anodization of aluminum films sputtered onto glass slides. The resulting transparent aluminum oxide films were characterized by scanning electron microscopy and variable angle ellipsometry. Subsequently, the film was modeled from the ellipsometric data taken. An underlying conductive medium is not necessarily needed to bring about nearly complete anodization of the aluminum layer. © 2003 The Electrochemical Society. All rights reserved.
Single Cell Motion in Aggregates of Embryonic Cells (1996)

We investigate the motion of individual pigmented retinal cells in aggregates of neural retinal cells obtained from chicken embryos. Individual cells in aggregates move randomly in the absence of chemical or adhesion gradients: the power spectrum of position and velocity versus time correspond to Brownian motion and the velocities are uncorrelated in time. Thus a quasithermal model of cell migration like the extended Potts model is appropriate. We also measure cell diffusivity and the cell velocity distribution. The results support the idea that collections of embryonic cells behave as liquids with membrane fluctuations playing the role of temperature.
3D Multi-chip Integration with System on Integrated Chips (SoIC™) (2019)

The electrical characterization of System on Integrated Chips (SoIC™), an innovative 3D heterogeneous integration technology manufactured in front-end of line with known-good-die is reported. Chiplets integration of devices including foundry leading edge 7nm FinFET technology with SoIC™ illustrates its advantages in high bandwidth density and high power efficiency, as compared with 2.5D and conventional 3D-IC with micro-bump/TSV.
Metaring-a full-duplex ring with fairness and spatial reuse (2002)

The design principles of a ring network with spatial reuse are described. The goal is to provide the same functions as designs that do not permit spatial reuse and concurrent transmission. A distributed fairness mechanism for this architecture is presented. The basic fairness mechanism can be extended for implementing multiple priority levels and integrating asynchronous with synchronous traffic. The ring is full-duplex and has two basic modes of operation: a buffer insertion mode for variable-size packets and a slotted mode for fixed-size packets. As a result, this architecture is suitable for a wide range of applications and environments. Concurrent access and spatial reuse permit simultaneous transmissions over disjoint segments of a bidirectional ring and, therefore, can increase the effective throughput by a factor of four or more. The efficiency of this architecture does not degrade as the bandwidth and physical size of the system increase. The combination of a full-duplex ring, spatial reuse, a reliable fairness mechanism, and the exploitation of recent advances in fiber-optic technology are the basis for the Metaring network architecture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Antigenic peptide binding by class I and class II histocompatibility proteins. (1994)

The recent determination of the structure of a class II MHC molecule complexed to a specific peptide reveals both similarities and differences with peptide binding by class I MHC.
Mapping the Melatonin Receptor. 7. Subtype Selective Ligands Based on β-Substituted<i>N</i>-Acyl-5-methoxytryptamines and β-Substituted<i>N</i>-Acyl-5-methoxy-1-methyltryptamines (2006)

A series of beta-substituted and beta,beta-disubstituted N-acyl 5-methoxy-1-methyltryptamines and 5-methoxytryptamines have been prepared as melatonin analogues to investigate the nature of the binding site of the melatonin receptor. The affinity of analogues was determined in a radioligand binding assay using cloned human MT(1) and MT(2) receptor subtypes expressed in NIH 3T3 cells. Agonist and antagonist potency of all analogues was measured using the pigment aggregation response of a clonal line of Xenopus laevis melanophores. beta-Methylmelatonin (17a) and beta,beta-dimethylmelatonin (17b), though showing a slight decrease in binding at human receptors, show an increase in potency on Xenopus. N-Butanoyl 5-methoxy-1-methyl-beta,beta-trimethylenetryptamine (12c) is an antagonist at human MT(1) receptors but an agonist at MT(2), while N-butanoyl 5-methoxy-1-methyl-beta,beta-tetramethylenetryptamine (13c) is an antagonist at MT(1) but had no action at MT(2) and is one of the first examples of an MT(1) selective antagonist.
Two-chamber Furnace for Flameless Atomic Absorption Spectrometry (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-chamber Furnace for Flameless Atomic Absorption SpectrometryD A. Church, T. Hadeishi, L. Leong, R D. McLaughlin, and B D. ZakCite this: Anal. Chem. 1974, 46, 9, 1352–1355Publication Date (Print):August 1, 1974Publication History Published online16 September 2003Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ac60345a601https://doi.org/10.1021/ac60345a601research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation (2019)

The state-of-the-art models for medical image segmentation are variants of U-Net and fully convolutional networks (FCN). Despite their success, these models have two limitations: (1) their optimal depth is apriori unknown, requiring extensive architecture search or inefficient ensemble of models of varying depths; and (2) their skip connections impose an unnecessarily restrictive fusion scheme, forcing aggregation only at the same-scale feature maps of the encoder and decoder sub-networks. To overcome these two limitations, we propose UNet++, a new neural architecture for semantic and instance segmentation, by (1) alleviating the unknown network depth with an efficient ensemble of U-Nets of varying depths, which partially share an encoder and co-learn simultaneously using deep supervision; (2) redesigning skip connections to aggregate features of varying semantic scales at the decoder sub-networks, leading to a highly flexible feature fusion scheme; and (3) devising a pruning scheme to accelerate the inference speed of UNet++. We have evaluated UNet++ using six different medical image segmentation datasets, covering multiple imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and electron microscopy (EM), and demonstrating that (1) UNet++ consistently outperforms the baseline models for the task of semantic segmentation across different datasets and backbone architectures; (2) UNet++ enhances segmentation quality of varying-size objects -- an improvement over the fixed-depth U-Net; (3) Mask RCNN++ (Mask R-CNN with UNet++ design) outperforms the original Mask R-CNN for the task of instance segmentation; and (4) pruned UNet++ models achieve significant speedup while showing only modest performance degradation. Our implementation and pre-trained models are available at https://github.com/MrGiovanni/UNetPlusPlus.