gebhart/patrepeval huggingface dataset:
Epigenetic reprogramming of the <i>RORC</i> locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg (2011)

The adoptive transfer of in vitro expanded Treg is a promising treatment option for autoimmune as well as alloantigen-induced diseases. Yet, concerns about the phenotypic and functional stability of Tregs upon in vitro culture command both careful selection of the starting population and thorough characterization of the final cell product. Recently, a high degree of developmental plasticity has been described for murine Treg and Th17 cells. Similarly, IL-17-producing FOXP3(+) cells have been detected among the CD45RA(-) memory-type subpopulation of human Tregs ex vivo. This prompted us to investigate the predisposition of human naïve and memory Tregs to develop into Th17 cells during polyclonal in vitro expansion. Here, we show that stimulation-induced DNA demethylation of RORC, which encodes the lineage-defining transcription factor for Th17 cells, occurs selectively in CD45RA(-) memory-type Tregs, irrespective of their FOXP3 expression level. On the contrary, naïve CD45RA(+) Tregs retain stable CpG methylation across the RORC locus even upon prolonged ex vivo expansion and in consequence show only a marginal tendency to express RORC and develop into IL-17-producing cells. These findings are highly relevant for the generation of therapeutic Treg products.
Viral Satellite RNAs for the Prevention of Cucumber Mosaic Virus (CMV) Disease in Field-Grown Pepper and Melon Plants (1998)

A benign viral satellite RNA, in combination with a mild strain of cucumber mosaic virus (CMV-S), was used as a "vaccine" or "preinoculum" to demonstrate the feasibility of protecting pepper (Capsicum annuum cv. California Wonder) and melon (Cucurbita melo cv. Janus des Canaries) against two severe CMV strains, CMV-D and CMV-16, in the final 2 years of a 4-year pilot field and greenhouse experiment. In the field, healthy pepper and melon seedlings challenged with CMV-D and CMV-16 reduced yields by 33 to 60%; CMV-S caused only limited yield reduction in pepper and had no effect on the yield of melon. Different time intervals between preinoculation of pepper and melon seedlings with CMV-S and challenge inoculation with the severe CMV strains were tested. All plants challenged 3 weeks after vaccination showed nearly complete protection from subsequent infection by severe strains. The yield from preinoculated and challenged pepper plants was 80% that of untreated plants, while the yield from preinoculated and challenged melon plants was increased slightly over the untreated control plants. The use of this technology for biological control of plant viruses is discussed.
[Effects of morphine on the formalin induced IL-2R beta mRNA expression of rat hippocampus]. (1998)

Using method of in situ hybridization, the effects of subcutaneous injection (s.c.) of formalin (For) into one hindpaw (hyperalgesia) on IL-2R beta mRNA expression in hippocampus (Hip) were studied. In addition, the effects of coadministration of morphine (i.p.) or ACTH (i.p.) with For (s.c.) were studied also. It was found that IL-2R beta mRNA was present in normal rat's Hip, intensely in granular cells of dentate gyrus and CA1-CA4 neurons. Subcutaneous injection of For increased IL-2R beta mRNA from 6 h to at least 24 h, reaching a peak at 12 h. Coadministration with morphine enhanced the effects of For on IL-2R beta mRNA expression, but no significant change was found with coadministration of ACTH. The above results suggest that IL-2R might be involved in pain modulation.
Trip (1996)

TRIP A Hyperfiction by Matthew Miller Copyright © 1996 Matthew Miller
Marginal oscillator optimized for radiofrequency size effect measurements (1976)

A marginal oscillator (1–50 MHz) operating at relatively high, stable oscillation levels, with very low noise, is described. Phase-sensitive detection of the real and imaginary parts of the surface impedance of metals or the nuclear susceptibility can be carried out from 0.5 Hz as a result of the low 1/f noise. The noise is dominated by this 1/f noise below 200 Hz, while at higher frequencies it is white and the oscillator has a noise factor of 1.15 or 0.6 dB.
Real-time lip-tracking for lipreading (1997)

This paper presents a new approach to lip tracking for lipreading.Instead of only tracking features on lips, we propose to track lips along with other facial features such as pupils and nostril.In the new approach, the face is rst located in an image using a stochastic skin-color model, the eyes, lip-corners and nostrils are then located and tracked inside the facial region.The new approach can e ectively improve the robustness of lip-tracking and simplify automatic detection and recovery of tracking failure.The feasibility of the proposed approach has been demonstrated by implementation of a lip tracking system.The system has been tested by a database that contains 900 image sequences of di erent speakers spelling words.The system has successfully extract lip regions from the image sequences to obtain training data for the audio-visual speech recognition system.The system has been also applied to extract the lip region in real-time from live video images to obtain the visual input for an audio-visual speech recognition system.On test sequences we have achieved a reduction of the number of frames with tracking failures by a factor of two using detection and prediction of outliers in the set of found features.
Time constant and lateral resonances of thermal vertical bimorph actuators (2002)

Thermal vertical bimorph actuators consist of silicon beams side-coated with aluminium. Upon heating they bend like a bimetal and produce movement in the wafer plane. We have measured the time constant describing the deflection response of the actuator to input pulses. Depending on the dimensions of the actuator, the time constant ranges from 0.5 ms to 3.8 ms. Lateral resonances of the first mode have been measured using thermal excitation and are found to be between 20 and 85 kHz.
Effect of cytokinins on the expression of LHCP-genes (2001)

The light-harvesting chlorophyll a/b-binding proteins (LHCP) function as carrier- proteins of antenna-pigments and are located in the thylakoid membrane of chloroplasts. They consist of a large family of polypeptides. To get a better insight in the regulation of their genes, we use transgenic tobacco plants with an elevated cytokinin- level. Using a special construct (Pssu-ipt) with a light-inducible promotor (from Pisum sativum), the concentration of cytokinins in the plants can be changed. Accumulation of cytokinins affects the photosynthetic apparatus (Synkova, H. et al., 1999 J. Plant Physiol. 155 173-182). More specific, the effect of cytokinins on the expression of the nuclear-encoded Lhcb-genes will be examined. Plants (Nicotiana tabacum L. cv. Petit Havana SR1) are cultivated on grodan in a greenhouse. This is done for WT as well as for the transgenic plants. Additional illumination is provided 16h a day with Agroson T (400W) and HTQ (400W) lamps (200µmol quanta m-2s-1). Samples are analysed by 2D-electrophoresis and Western blotting.
Vestibular Schwannoma Growth Rates in Neurofibromatosis Type 2 Natural History Consortium Subjects (2004)

Slightly greater than 1 in 10 diagnosed NF2-related vestibular schwannomas increased in size by at least 5 mm by 4 years of follow-up, if still untreated at that time.
Information Display System Based on Power Line Carrier (2010)

Power line carrier communication provides a useful new means of communication,with good prospects and market potential.The information display system is based on BWP10A power line carrier module.Using power line,the host transmits an order or some information through the serial port,and the slave displays them through the LED dot matrix after the information has been processed in communication distance,as long as you plug in 220V AC power.Without requiring other data line,power line carrier communication greatly facilitates the release of information.
Deconvolution-Based CT and MR Brain Perfusion Measurement: Theoretical Model Revisited and Practical Implementation Details (2011)

Deconvolution-based analysis of CT and MR brain perfusion data is widely used in clinical practice and it is still a topic of ongoing research activities. In this paper, we present a comprehensive derivation and explanation of the underlying physiological model for intravascular tracer systems. We also discuss practical details that are needed to properly implement algorithms for perfusion analysis. Our description of the practical computer implementation is focused on the most frequently employed algebraic deconvolution methods based on the singular value decomposition. In particular, we further discuss the need for regularization in order to obtain physiologically reasonable results. We include an overview of relevant preprocessing steps and provide numerous references to the literature. We cover both CT and MR brain perfusion imaging in this paper because they share many common aspects. The combination of both the theoretical as well as the practical aspects of perfusion analysis explicitly emphasizes the simplifications to the underlying physiological model that are necessary in order to apply it to measured data acquired with current CT and MR scanners.
Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer (2013)

Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance of prostate cancer. We showed that DHT was intratumorally synthesized from the inactive androgen metabolites 5α-androstane-3α/β,17β-diol (3α/β-diol) in prostate cancer cells via different pathways in a concentration-dependent manner. Additionally, long-term culture in androgen-deprived media increased transcriptomic expression of 17β-hydroxysteroid dehydrogenase type 6 (HSD17B6), a key enzyme of oxidative 3α-HSD that catalyzes the conversion of 3α-diol to DHT in prostate cancer cells. Correspondingly, the score for HSD17B6 in tissues of 42 prostate cancer patients undergoing androgen deprivation therapy (ADT) was about 2-fold higher than that in tissues of 100 untreated individuals. In men receiving ADT, patients showing biochemical progression had a higher HSD17B6 score than those without progression. These results suggested that 3α/β-diol also represent potential precursors of DHT, and the back conversion of DHT from androgen derivatives can be a promising target for combination hormone therapy.
Image Texture Classification Using Combined Grey Level Co-Occurrence Probabilities and Support Vector Machines (2008)

Texture refers to properties that represent the surface or structure of an object and is defined as something consisting of mutually related elements. The main focus in this study is to do texture segmentation and classification for texture digital images. Grey level co-occurrence probabilities (GLCP) method is being used to extract features from texture image. Gaussian support vector machines (GSVM) have been proposed to do classification on the extracted features. A popular Brodatz texture album had been chosen to test out the result. In this study, a combined GLCP-GSVM shows an improvement over GLCP in terms of classification accuracy.
The Induction Machine Handbook (2010)

Often called the workhorse of industry, the advent of power electronics and advances in digital control are transforming the induction motor into the racehorse of industrial motion control. Now, the classic texts on induction machines are nearly three decades old, while more recent books on electric motors lack the necessary depth and detail on ind
Stencil technique for areola tattooing. A simple solution for quickly performed, homogeneous tattoos with regular edges (2015)

Areola tattooing marks the end of a patient’s treatment plan by turning a volume into a breast. Although seemingly simple, the technique must be performed carefully to get a uniform color and a regular form. Inherent to any technical learning curve, the first tattoos may display heterogeneous staining or contour defects that are difficult to rectify. We propose a simple, reliable and reproducible procedure using a stencil for homogeneous tattoos with regular edges. First, electrocardiogram round electrodes are placed on the breast of the standing patient to determine the best tattoo position and the outline of the areola is drawnwith a dermographic pencil. After skin disinfection, the outline of the areola is marked out again with a sterile dermographic pencil and the back of a Comfeel Plus© dressing (Coloplast A/S, Espergaerder, Denmark) is applied over the freshly penciled mark to copy the outline of the areola. Using scissors, a hole in the shape of the areola is cut out in the Comfeel© dressing. On dried skin, the dressing is carefully placed over the future areola and the pigment applied to the skin. The tattoo machine is placed about five times over the entire hole in horizontal, vertical, oblique right and left movementse the dermograph resting against the dressing at each passage (Figure 1). The same pattern is repeated as needed until a homogeneous tattoo is obtained (Figure 2). The technique is illustrated with a video : (https://www.youtube.com/watch? v1⁄4vTEar38SkiU&feature1⁄4youtube_gdata).
Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development (1997)

Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of developmental processes, but their functions during early vertebrate brain development are largely unknown. To investigate this problem, we have compared by in situ hybridization the expression of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7). Striking co-expression of these Bmps is observed within the dorsomedial telencephalon, coincident with a future site of choroid plexus development. Bmp co-expression overlaps that of Msx1 and Hfh4, and is complementary to that of Bf1. The domain of Bmp co-expression is also associated with limited growth of the neuroectoderm, as revealed by morphological observation, reduced cell proliferation, and increased local programmed cell death. In vitro experiments using explants from the embryonic lateral telencephalic neuroectoderm reveal that exogenous BMP proteins (BMP4 and BMP2) induce expression of Msx1 and inhibit Bf1 expression, a finding consistent with their specific expression patterns in vivo. Moreover, BMP proteins locally inhibit cell proliferation and increase apoptosis in the explants. These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death.
Comprehension Assistant for Languages of Baltic States (2007)

Proceedings of the 16th Nordic Conference \nof Computational Linguistics NODALIDA-2007.\nEditors: Joakim Nivre, Heiki-Jaan Kaalep, Kadri Muischnek and Mare Koit.\nUniversity of Tartu, Tartu, 2007.\nISBN 978-9985-4-0513-0 (online)\nISBN 978-9985-4-0514-7 (CD-ROM)\npp. 167-174.
Nuclear texture measurements in image cytometry. (1995)

DNA image cytometry is widely used in cytopathology as a means to obtain objective information concerning the diagnosis and prognosis of human cancer. Using specially designed devices, the high resolution spatial and photometric information is available in the images of a microscopic field. If quantitative DNA specific stains are used the chromatin distribution in the cell nuclei can be measured, which is one of the critical features for cytopathological analysis. In normal cells, changes in the chromatin appearance reflect changes in the activation patterns of genes. In tumors, dramatic changes in the nuclear chromatin appearance are common and have been associated with the progression of the disease. Features describing the chromatin distribution pattern are referred to as texture features. Nuclear texture features are sensitive to the differences between the various descriptive classes of chromatin patterns. In this paper we discuss the main categories of nuclear texture measurements. Texture features can be roughly divided into the following categories: 1) descriptive statistics of chromatin distribution; 2) discrete texture features; 3) range extreme; 4) markovian; 5) run length and 6) fractal texture features. Representative features of each of the above categories are discussed together with mathematical formulas, simple figures for explanation as well as images of typical cells which differ significantly in some texture features. Key references are also provided.
Study of symmetrical and related components through the theory of linear vector spaces (1966)

The paper proposes a study of symmetrical and related components, based on the theory of linear vector spaces. Using the concept of equivalence, the transformation matrixes of Clarke, Kimbark, Concordia, Boyajian and Koga are shown to be column equivalent to Fortescue's symmetrical-component transformation matrix. With a constraint on power, criteria are presented for the choice of bases for voltage and current vector spaces. In particular, it is shown that, for power invariance, either the same orthonormal (self-reciprocal) basis must be chosen for both voltage and current vector spaces, or the basis of one must be chosen to be reciprocal to that of the other. The original α, β, 0 components of Clarke are modified to achieve power invariance. For machine analysis, it is shown that invariant transformations lead to reciprocal mutual inductances between the equivalent circuits. The relative merits of the various components are discussed.
Control technology overview report: CFC (chlorofluorocarbon) emissions from rigid foam manufacturing. Final report, March-November 1986 (1988)

The report estimates total chlorofluorocarbon (CFC) emissions from the various rigid foam manufacturing processes and from the foam products themselves, and examines potential methods for reducing these emissions. Options studied include replacement of CFC-blown products with alternative products not requiring CFCs, replacement of ozone-depleting CFCs with other chemicals less likely to destroy stratospheric ozone, and recovery/recycle of CFCs released during manufacturing processes. In the production of rigid cellular foams, CFCs are used as physical blowing agents to reduce foam density and impart thermal insulating properties. Such rigid foams include polyurethane, polystyrene, polyethylene, polypropylene, polyvinyl chloride, and phenolic foams. Uses of these foams include building insulation, packaging materials, and single-service dinnerware. Depletion of stratospheric ozone through action of halocarbons, particularly CFCs, has been the subject of extensive study and wide debate. Although many uncertainties remain, current scientific evidence strongly suggests that anthropogenic CFCs could contribute to depletion of the stratospheric ozone layer as was first postulated in 1974.
GM<sub>1</sub> Ganglioside for Acute Ischemic Stroke: Trial Design Issues (1998)

GM1 ganglioside decreases the severity of ischemic brain lesions in experimental models, although the mechanism is uncertain. In clinical trials involving patients with stroke, efficacy has been reported in some but not in others. However, some of the latter also showed efficacy after analyses not planned before the trial began. Analyses of the trials done to date revealed design differences sufficiently large so as to preclude meta-analysis of the results. Moreover, flaws in these studies may account for some of their failure to demonstrate that GM1 therapy is efficacious in ischemic stroke. Several of these flaws are discussed, including small sample size; attrition of the study cohort; inclusion of stroke severity and type that made demonstrations of a beneficial effect difficult; use of inappropriate clinical and outcome measuring instruments; delay in enrollment; inappropriate statistical analyses; inadequate dose; inappropriate route of administration; a too short duration of treatment. Improvements in these design features in future clinical trials of GM1 may yet demonstrate efficacy of this drug in acute ischemic stroke.
Why bortezomib cannot go with ＂green＇？ (2013)

Eat more‘green’or eat‘five a day’is one of the most important healthy lifestyle behaviours in the 21 century.Aiming to fight cancer effectively,more than half patients use vitamins or herbs concurrently with conventional anticancer treatment.Flavonoids or polyphenols existing in vegetables,fruits and green tea are common plant pigments with antioxidant properties and considered acting as cancer preventing or anti-cancer agents.Recently it was found that some flavonoids and vitamin C in diet or supplements have antagonistic effect with the anti-cancer drug bortezomib.Bortezomib is a specific inhibitor for proteasome and is currently used for treatment of relapsed and refractory multiple myeloma.Despite its successful rates in treating multiple myeloma and other solid tumors,it is unable to kill leukemic cells in the blood.It was recently revealed that some flavonoids and vitamin C present in green leaves and green teas in the blood can neutralize bortezomib by directly interaction between two chemicals.Here we summarize why dietary flavonoids should be avoided in patients who take bortezomib as chemotherapeutic drug.
Temporal studies on the tissue compartmentalization of bone sialoprotein (BSP), osteopontin (OPN), and SPARC protein during bone formation In Vitro (1992)

To study the role of noncollagenous proteins in bone formation, the synthesis and tissue distribution of BSP (bone sialoprotein), OPN (osteopontin) and SPARC (secreted protein acidic and rich in cysteine) were analyzed using pulse-chase and continuous labeling protocols during bone formation by cultures of rat calvarial cells. Following a 1 h labeling period with [35S]methionine or [35SO4], radiolabeled BSP was rapidly lost from the cells and appeared transiently in the culture medium and in a 4 M GuHCl extract (G1) of the mineralized tissue. Coinciding with the loss of BSP from these compartments, radiolabeled BSP increased in demineralizing, 0.5 M EDTA extracts (E) of the bone, in a subsequent GuHCl extract (G2), and in a bacterial collagenase digest (CD fraction) of the extracted tissue, over a 24 h chase period. In comparison, the 55 kDa form of OPN, with a small amount of the 44 kDa OPN, was secreted almost entirely into the culture medium. Most of the 44 kDa OPN, together with some 55 kDa OPN, accumulated rapidly in the E extract but could not be detected in either G extract or in the CD fraction. SPARC appeared transiently in the G1 extract, but was otherwise quantitatively secreted into the culture medium from where it was lost by complexing and/or degradation. When cultures were continuously labeled over a 12 day period with [35S]methionine, radiolabeled BSP and 44 kDa OPN accumulated in the E extract together with a small amount of SPARC. Some radiolabeled BSP also accumulated in the G2 extract. From the relative incorporation of [35SO4] over the same time period, a time-dependent loss in sulphate from the BSP was evident. Using a 24 h pulse-labeling protocol, the amount of radiolabeled BSP and OPN in the E extract and the BSP in the G2 extract were not altered significantly over a 12-day chase period. These studies demonstrate that the 44 kDa OPN and most of the BSP are rapidly bound to the hydroxyapatite crystals where they may regulate crystal formation and growth during bone formation. Some BSP is deposited in the osteoid and appears to become masked by the formation of hydroxyapatite, indicating a potential role for this protein in epitactic nucleation of hydroxyapatite crystal formation.