gebhart/patrepeval huggingface dataset:
Persistent electrical polarization in polyelectrolyte membranes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPersistent electrical polarization in polyelectrolyte membranesCharles Linder and Irving F. MillerCite this: J. Phys. Chem. 1972, 76, 23, 3434–3445Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/j100667a024https://doi.org/10.1021/j100667a024research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Nutrients removal in MBRs for municipal wastewater treatment (2005)

Owing to increasingly stringent effluent quality requirements, intensifications of the conventional activated sludge process (ASP) are required. Due to high biomass concentrations employed, higher metabolic rates and better nutrient removal are possible in membrane bioreactors (MBRs). Decoupling of hydraulic and solids residence times offers additional possibilities for process design and optimisation. Recently, unconventional concepts like post-denitrification and enhanced biological phosphorus removal in MBRs have emerged. The objective of this paper is to present current knowledge on nutrients removal in MBRs and trends in process optimisation in comparison with conventional ASP.
Crisis in English Poetry, 1880-1940 (1951)

Crisis in English Poetry, 1880–1940 Get access Crisis in English Poetry, 1880–1940. By Vivian De Sola Pinto. Hutchinson's University Library. 7s. 6d. Margaret Willy Margaret Willy Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 8, Issue 48, Autumn 1951, Pages 290–291, https://doi.org/10.1093/english/8.48.290 Published: 01 October 1951
The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal (2001)

Cytokines, such as interleukin-2 (IL-2), activate intracellular signaling pathways via rapid tyrosine phosphorylation of their receptors, resulting in the activation of many genes involved in cell growth and survival. The deubiquitinating enzyme DUB-2 is induced in response to IL-2 but as yet its function has not been determined. The results of this study show that DUB-2 is expressed in human T-cell lymphotropic virus-I (HTLV-1)-transformed T cells that exhibit constitutive activation of the IL-2 JAK/STAT (signal transducers and activators of transcription) pathway, and when expressed in Ba/F3 cells DUB-2 markedly prolonged IL-2-induced STAT5 phosphorylation. Although DUB-2 did not enhance IL-2-mediated proliferation, when withdrawn from growth factor, cells expressing DUB-2 had sustained STAT5 phosphorylation and enhanced expression of IL-2-induced genes cis and c-myc. Moreover, DUB-2 expression markedly inhibited apoptosis induced by cytokine withdrawal allowing cells to survive. Taken together these data suggest that DUB-2 can enhance signaling through the JAK/STAT pathway, prolong lymphocyte survival, and, when constitutively expressed, may contribute to the activation of the JAK/STAT pathway observed in some transformed cells.
Terrorism and Self-Determination: The Fatal Nexus (1980)

This comment explores how definitions of terrorism and self-determination affect the laws pertaining to these concepts and actions.
Compression of 3D Triangle Meshes with a Generalized Parallelogram Prediction Scheme Based on Vector Quantization (2010)

The transmission and storage of large amounts of vertex geometry data are required for rendering geometrically detailed 3D graphic models. To mitigate bandwidth requirements, vector quantization (VQ) is an effective lossy vertex data compression technique for triangular meshes. In this paper, we present a new vertex encoding scheme based on VQ. Particularly, we propose a novel prediction method that generalizes the conventional parallelogram prediction method and further reduces the prediction error. During the encoding process, the vertex to be encoded is predicted by all the encoded vertices neighboring to it within a large edge-distance, instead of the encoded vertices directly connecting to it with 1-edge-distance as in the conventional parallelogram prediction. Experimental results show that, compared with the vertex encoding scheme based on the conventional parallelogram prediction, the proposed algorithm consistently achieves a higher encoding quality at the same bit rate.
Humoral and Cellular Immune Responses to Synthetic Peptides of the <i>Leishmania donovani </i>Kinetoplastid Membrane Protein‐11 (1998)

Native kinetoplastid membrane protein-11 (KMP-11), purified from crude extracts of Leishmania donovani parasites, activates T cells from individuals who have recovered from visceral leishmaniasis. In this work we used three 38-mer peptides spanning the amino acid sequence of the L. donovani KMP-11 as solid-phase ligands in enzyme-linked immunosorbent assays (ELISAs) and as stimulating antigens in lymphoproliferative assays in order to evaluate humoral and cellular immune responses to well-defined sequences of the protein. Antibody reactivity against the three peptides was measured in plasma from 63 Sudanese visceral leishmaniasis patients (VL) and the percentage of patients with anti-KMP-11 antibodies in ELISA were 37% (KMP-11-1), 30% (KMP-11-2) and 58% (KMP-11-3). The fraction of VL patients with measurable antibody reactivity in one or more of the three ELISAs was 79%. Cross-reactivity to the KMP-11 peptides was detected in plasma from Sudanese patients suffering from Leishmania major infections and in plasma from Sudanese and Danish patients infected with Plasmodium falciparum. In lymphoproliferative assays, 10 of 17 PBMC isolates from donors previously infected with L. donovani showed a response to one or more of the three KMP-11 peptides.
Synthesis and biological evaluation of novel benzo[b]xanthone derivatives as potential antitumor agents (2013)

Nine novel aminoalkoxy substituted benzoxanthones (3a-3i) were synthesized. Their antitumor activities were evaluated in five human solid tumor cell lines including Hep-G2, BEL-7402, HeLa, MGC-803 and CNE by MTT method. The results showed that most of the compounds displayed moderate to good inhibitory activities on the tested cancer cell lines in vitro, among them compounds 3a and 3h showed higher antitumor activity than other tested compounds against most cell lines. The influence of two kinds of structural factors including the terminal amino group and length of carbon spacers on the anticancer activities were explored to discuss the preliminary structure-activity relationships.
Preparation of Biodegradable Nanoparticles and Their Use in Transfection (2008)

INTRODUCTIONBiodegradable nanoparticles (NPs) are colloidal particles with a gene of interest encapsulated inside a polymeric matrix. They are typically 100 nm in diameter, and are formulated using FDA-approved, biodegradable, biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) or polylactide (PLA). The NPs are taken up by cells via an endocytic process, and the encapsulated plasmid DNA entrapped in NPs is protected from degradation by both extra- and intracellular nucleases. It is released slowly, sustaining gene delivery and gene expression. In contrast, higher but transient gene expression is observed with lipid- or polymer-based complexes where most of the delivered DNA is available quickly for transfection. Thus, unlike other nonviral gene delivery systems, NPs thus constitute a sustained gene expression vector. Sustained gene expression is advantageous, especially when the half-life of the expressed protein is very low or when chronic gene delivery is required for therapeutic efficacy. This protocol describes a method for nanoencapsulation of DNA and the subsequent use of NPs for transfection.
Electroanalytical Assessment of the Effect of Ni:Fe Stoichiometry and Architectural Expression on the Bifunctional Activity of Nanoscale Ni<sub><i>y</i></sub>Fe<sub>1–<i>y</i></sub>O<i>x</i> (2017)

Electrocatalysis of the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) was assessed for a series of Ni-substituted ferrites (Ni<sub>y</sub>Fe<sub>1-y</sub>Ox, where y = 0.1 to 0.9) as expressed in porous, high-surface-area forms (ambigel and aerogel nanoarchitectures). We then correlate electrocatalytic activity with Ni:Fe stoichiometry as a function of surface area, crystallite size, and free volume. In order to ensure in-series comparisons, calcination at 350 °C/air was necessary to crystallize the respective Ni<sub>y</sub>Fe<sub>1-y</sub>Ox nanoarchitectures, which index to the inverse spinel structure for Fe-rich materials (y ≤ 0.33), rock salt for the most Ni-rich material (y = 0.9), and biphasic for intermediate stoichiometry (0.5 ≤ y ≤ 0.67). In the intermediate Ni:Fe stoichiometric range (0.33 ≤ y ≤ 0.67), the OER current density at 390 mV increases monotonically with increasing Ni content and increasing surface area, but with different working curves for ambigels versus aerogels. At a common stoichiometry within this range, ambigels and aerogels yield comparable OER performance, but do so by expressing larger crystallite size (ambigel) versus higher surface area (aerogel). Effective OER activity can be achieved without requiring supercritical-fluid extraction as long as moderately high surface area, porous materials can be prepared. We find improved OER performance (η decreases from 390 to 373 mV) for Ni<sub>0.67</sub>Fe<sub>0.33</sub>Ox aerogel heat-treated at 300 °C/Ar, owing to an increase in crystallite size (2.7 to 4.1 nm). For the ORR, electrocatalytic activity favors Fe-rich Ni<sub>y</sub>Fe<sub>1-y</sub>Ox materials; however, as the Ni-content increases beyond y = 0.5, a two-electron reduction pathway is still exhibited, demonstrating that bifunctional OER and ORR activity may be possible by choosing a nickel ferrite nanoarchitecture that provides high OER activity with sufficient ORR activity. Assessing the catalytic activity requires an appreciation of the multivariate interplay among Ni:Fe stoichiometry, surface area, crystallographic phase, and crystallite size.
Link-time optimization of address calculation on a 64-bit architecture (1994)

Compilers for new machines with 64-bit addresses must generate code that works when the memory used by the program is large. Procedures and global variables are accessed indirectly via global address tables, and calling conventions include code to establish the addressability of the appropriate tables. In the common case of a program that does not require a lot of memory, all of this can be simplified considerably, with a corresponding reduction in program size and execution time.We have used our link-time code modification system OM to perform program transformations related to global address use on the Alpha AXP. Though simple, many of these arewhole-program optimizations that can be done only when we can see the entire program at once, so link-time is an ideal occasion to perform them.This paper describes the optimizations performed and shows their effects on program size and performance. Relatively modest transformations, possible without moving code, improve the performance of SPEC benchmarks by an average of 1.5%. More ambitious transformations, requiring an understanding of program structure that is thorough but not difficult at link-time, can do even better, reducing program size by 10% or more, and improving performance by an average of 3.8%.Even a program compiled monolithically with interprocedural optimization can benefit nearly as much from this technique, if it contains statically-linked pre-compiled library code. When the benchmark sources were compiled in this way, we were still able to improve their performance by 1.35% with the modest transformations and 3.4% with the ambitious transformations.
BYPASS: topology-aware lookup overlay for dht-based P2P file locating services (2004)

In this paper we propose a peer-to-peer file location system, BYPASS, to enhance the distributed file lookup time in DHT-based P2P systems. BYPASS constructs a secondary overlay in which file location information is distributed considering heterogeneity of peer capabilities and network proximity between requests and results. The secondary overlay in BYPASS allows only high-capability peers to participate in the system-wide file lookup and takes advantage of physical network proximity based on the autonomous system (AS) network topology. We evaluate effectiveness of BYPASS using a set of large-scale simulations. The results show that BYPASS can significantly reduce file lookup latency at the cost of additional yet acceptable storage and network resources.
A simple fault-tolerant digital voter circuit in TMR nanoarchitectures (2010)

Nanoelectronic systems are now more and more prone to faults and defects, permanent or transient. Redundancy techniques are implemented widely to increase the reliability, especially the TMR - Triple Modular Redundancy. However, many researchers assume that the voter is perfect and this may not be true. This paper proposes a simple but effective fault-tolerant voter circuit which is more reliable and less expensive. Experimental results demonstrate its improvement over the former TMR structures.
Predicting Outcome after Traumatic Brain Injury (2011)

The purpose of this review is to look at the most recent work carried out on predicting outcome after traumatic brain injury (TBI). TBI is a leading cause of death and disability but prediction of long-term outcome for individual patients is difficult. In particular, predicting outcome in the first few hours or days after injury is limited by the paucity of scoring systems or clinical models available. Many clinical variables have been studied to determine if they may play a role in outcome prediction, including age, admission Glasgow Coma Score and pupillary reactivity. Newer variables being studied include serum biomarkers, abnormalities seen on magnetic resonance imaging and data obtained from evoked potentials and electroencephalography studies. There are many factors that impact on outcome and a perfect model is yet to be developed. Models must take into account the economic status of the country in which the trauma occurs. It is important that less affluent nations are not left behind in the search for accurate prognostic modelling.
Functional screening identifies miR-315 as a potent activator of Wingless signaling (2007)

The existence of vast regulatory networks mediated by microRNAs (miRNAs) suggests broad potential for miRNA dysfunction to contribute to disease. However, relatively few miRNA-target interactions are likely to make detectable contributions to phenotype, and effective strategies to identify these few interactions are currently wanting. We hypothesized that signaling cascades represent critical points of susceptibility to miRNA dysfunction, and we developed a strategy to test this theory by using quantitative cell-based screens. Here we report a screen for miRNAs that affect the Wingless (Wg) pathway, a conserved pathway that regulates growth and tissue specification. This process identified ectopic miR-315 as a potent and specific activator of Wg signaling, an activity that we corroborated in transgenic animals. This miR-315 activity was mediated by direct inhibition of Axin and Notum, which encode essential, negatively acting components of the Wg pathway. Genetic interaction tests substantiated both of these genes as key functional targets of miR-315. The ability of ectopic miR-315 to activate Wg signaling was not a trivial consequence of predicted miRNA-target relationships because other miRNAs with conserved sites in the Axin 3' UTR neither activated Wg outputs nor inhibited an Axin sensor. In summary, activity-based screening can selectively identify miRNAs whose deregulation can lead to interpretable phenotypic consequences.
Three-dimensional visualisation of soft biological structures by X-ray computed micro-tomography (2016)

Whereas the two-dimensional (2D) visualisation of biological samples is routine, three-dimensional (3D) imaging remains a time-consuming and relatively specialised pursuit. Current commonly adopted techniques for characterising the 3D structure of non-calcified tissues and biomaterials include optical and electron microscopy of serial sections and sectioned block faces, and the visualisation of intact samples by confocal microscopy or electron tomography. As an alternative to these approaches, X-ray computed micro-tomography (microCT) can both rapidly image the internal 3D structure of macroscopic volumes at sub-micron resolutions and visualise dynamic changes in living tissues at a microsecond scale. In this Commentary, we discuss the history and current capabilities of microCT. To that end, we present four case studies to illustrate the ability of microCT to visualise and quantify: (1) pressure-induced changes in the internal structure of unstained rat arteries, (2) the differential morphology of stained collagen fascicles in tendon and ligament, (3) the development of Vanessa cardui chrysalises, and (4) the distribution of cells within a tissue-engineering construct. Future developments in detector design and the use of synchrotron X-ray sources might enable real-time 3D imaging of dynamically remodelling biological samples.
Introduction and Table of Contents (2007)

This is the table of contents and introduction to the edited volume Theodor Adorno, published by Ashgate as part of the International Library of Essays in the History of Social and Political Thought. Posted in OpenBU at author's request and with publisher's consent.
Internal mandibular distraction to relieve airway obstruction in infants and young children with micrognathia (2004)

Micrognathia may cause upper airway obstruction requiring complex medical interventions and sometimes tracheostomy. The role of distraction techniques to lengthen the mandible is yet to be clarified. The aim of this paper is to present a series of five cases in which mandibular lengthening by osteotomy and internal distraction was used to relieve airway obstruction. Five patients whose ages ranged from 4-39 months (mean, 15 months) were managed at our center with internal distraction osteogenesis to relieve airway obstruction. Three patients had a tracheostomy, and two patients had refractory airway obstruction prior to distraction. Following osteotomy and insertion of internal distraction devices, the mandible was distracted a mean of 17 mm (range, 15-25 mm). The distraction devices were removed at the end of a consolidation period ranging from 3-10 weeks. Two of 3 patients with a tracheostomy were decannulated, while the third patient with tracheostomy is awaiting choanal atresia repair before being decannulated. The two patients who were not managed with a tracheostomy but who had persistent upper airway obstruction have not required further airway intervention after mandibular distraction. In conclusion, mandibular lengthening by distraction osteogenesis can relieve airway obstruction in infants and small children. This is a promising new technique that may avoid the need for tracheostomy in some infants with micrognathia, and facilitate early decannulation in those who have a tracheostomy.
Aplyronine A, a potent antitumor substance and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAplyronine A, a potent antitumor substance and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodaiKiyoyuki Yamada, Makoto Ojika, Takeshi Ishigaki, Yoshifumi Yoshida, Hisao Ekimoto, and Masayuki ArakawaCite this: J. Am. Chem. Soc. 1993, 115, 23, 11020–11021Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ja00076a082https://doi.org/10.1021/ja00076a082research-articleACS PublicationsRequest reuse permissionsArticle Views894Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Thyroid hormone regulates expression of a transfected alpha-myosin heavy-chain fusion gene in fetal heart cells. (1987)

In ventricular muscle, 3,5,3'-triiodo-L-thyronine (T3) stimulates the expression of the alpha-myosin heavy-chain (alpha-MHC) gene. To test for gene elements required for induction, a fragment of the alpha-MHC gene containing 2.9 kilobases of 5' flanking sequences and 420 base pairs of DNA 3' to the transcription initiation site was linked to the coding sequences of the bacterial chloramphenicol acetyltransferase (CAT) gene. The alpha-MHC fusion gene was introduced into primary cultures of fetal rat heart myocytes. Induction of the transfected gene was monitored by assaying CAT activity while endogenous alpha-MHC mRNA expression was measured by using a synthetic oligonucleotide probe complementary to sequences in the 3' untranslated region of the mRNA. Without T3, CAT activity was only slightly greater than background. When T3 at a final concentration of 10 nM was added to the cultures, CAT activity was increased 8-fold by 48 hr. The response time and doses of T3 required for induction of CAT activity and alpha-MHC mRNA in transfected cells were similar, suggesting that the synthetic and endogenous genes may have a common mechanism of control. When simian virus 40 enhancer and early promoter sequences were included in the construct, CAT activity was constitutively expressed, but it could be increased 7-fold by the addition of T3. Several deletions were introduced into the 5' flanking sequences of the alpha-MHC fragment and the effects on induction of CAT activity were examined. Progressive deletions of 5' sequences from positions -947 to -374 reduced but did not eliminate induction of CAT activity, suggesting that more than one region may be required for optimal induction by thyroid hormone. The results indicate that DNA sequences required for efficient induction by T3 are present in the 5' flanking sequences of the alpha-MHC gene.