gebhart/patrepeval huggingface dataset:
Polymorphism within the 3′ flanking region of the bovine growth hormone receptor gene (1998)

Growth hormone receptor (GHR) has a major role in the regulation of growth hormone action, and thus, is an obvious candidate gene associated with milk production traits in mammals. The present authors have sequenced 273 bp of the 3' flanking region of the bovine GHR, and found three length variants and one base substitution polymorphism in this region. Allele frequencies of the length variants differ between Finnish native and commercial dairy cattle breeds. The chromosomal localization of GHR was confirmed to bovine chromosome 20 by synteny mapping and linkage analysis.
Mechanocaloric effects in shape memory alloys (2016)

Shape memory alloys (SMA) are a class of ferroic materials which undergo a structural (martensitic) transition where the associated ferroic property is a lattice distortion (strain). The sensitiveness of the transition to the conjugated external field (stress), together with the latent heat of the transition, gives rise to giant mechanocaloric effects. In non-magnetic SMA, the lattice distortion is mostly described by a pure shear and the martensitic transition in this family of alloys is strongly affected by uniaxial stress, whereas it is basically insensitive to hydrostatic pressure. As a result, non-magnetic alloys exhibit giant elastocaloric effects but negligible barocaloric effects. By contrast, in a number of magnetic SMA, the lattice distortion at the martensitic transition involves a volume change in addition to the shear strain. Those alloys are affected by both uniaxial stress and hydrostatic pressure and they exhibit giant elastocaloric and barocaloric effects. The paper aims at providing a critical survey of available experimental data on elastocaloric and barocaloric effects in magnetic and non-magnetic SMA.This article is part of the themed issue 'Taking the temperature of phase transitions in cool materials'.
Apoptosis-Mediated Cytotoxic Effects of Ibandronic Acid on Hormone- and Drug-Refractory Prostate Cancer Cells and Human Breast Cancer Cells (2010)

Over 80% of patients with advanced breast and prostate cancer ultimately develop bone metastases. Ibandronic acid has proven efficacy for treatment of bone metastasis secondary to breast cancer. This study was designed to investigate the cytotoxic and apoptotic effects of ibandronic acid on hormone- and drug-refractory prostate carcinoma DU-145 and human breast cancer MCF-7 cell lines. Cytotoxicity was evaluated using an XTT cell proliferation kit, and apoptosis was assessed by enzyme-linked immunosorbent assay (histone-DNA fragmentation) and measurement of caspase 3/7 activity. With increasing concentrations of ibandronic acid there was a dose- and time-dependent decrease in cell numbers. MCF-7 cells were more resistant than DU-145 cells (half maximal inhibitory concentrations of 122 and 90 microM, respectively). Ibandronic acid induced apoptosis in both cell lines. The study showed an apoptosis-mediated cytotoxic effect for ibandronic acid (in addition to the already known osteoclast inhibiting effect) in breast cancer patients with bone metastases; which was also observed in prostate cancer cells. Further clinical studies involving breast and prostate cancer patients with bone metastases are warranted to confirm these findings.
A Metadata Registry to Facilitate the Search and Retrieval of Electrocardiograms (2009)

Sequential electrocardiograms (ECGs) are very useful for personalized diagnosis. It is therefore very useful to search various electrocardiographs or ECG management systems connected to the Internet for a particular patient's ECGs. This is an interesting but not completely solved problem. In this paper, we present an experimental study of our metadata registry aimed at facilitating the search for and retrieval of a patient's ECGs via the Internet. The metadata registry was developed based on the ebXML registry methodology and Web service technique. An assessment test in an experimental scenario shows that it is feasible to apply the metadata registry to discovering and retrieving a patient's ECGs resident in a number of emulated electrocardiographs placed in the Internet. This study demonstrates a useful framework for ECG sharing through the Internet.
The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants (2012)

到 Arabidopsis 幼苗的螃蟹壳几丁质或 pentamer 几丁质 oligosaccharide 的申请增加了忍耐到咸度在野类型然而并非在 LysM 像受体的 Kinase1 (CERK1/LysM RLK1 ) 的猛烈异种基因，知道在表明外长的几丁质导致的防卫回答起一个关键作用。从真菌 Trichoderma asperelleoides T203 的 endochitinase chit36 和 hexoaminidase excy1 基因显示出的 Arabidopsis 植物 overexpressing 增加了忍耐到咸度，重金属的压力，和 Botrytis cinerea 感染。抵抗的线， overexpressing 在不同层次的真菌的 chitinases，是到 lysm rlk1 异种的 outcrossed。独立同型结合的混血儿失去了抵抗到关於生命、不能生活的压力，尽管有提高的 chitinase 活动。 270 压力相关的基因的表示分析包括反应的氧种类( ROS )和几丁质导致的那些，揭示经常的起来规定(至少双重) 10 ，在 chitinase-overexpressing 的基因排队并且一另外其表情没在怀有变化的 lysm rlk1 大美人异种或混血儿被提高的 76 导致盐的基因。这些调查结果阐明那个导致几丁质的发信号由 LysM RLK1 调停了受体没被限制到关於生命的压力反应而且包含不能生活压力的发信号和罐头被 chitinases 的宫外的表示在植物传送。
A master-slave blockchain paradigm and application in digital rights management (2018)

Upon flaws of current blockchain platforms of heavyweight, large capacity of ledger, and time-consuming of synchronization of data, in this paper, we proposed a new paradigm of master-slave blockchain scheme (MSB) for pervasive computing that suitable for general PC, mobile device such as smart phones or PADs to participants in the working of mining and verification, in which we separated traditional blockchain model in 2 layer defined as master node layer and a series of slavery agents layer, then we proposed 2 approaches for partially computing model(P-CM) and non-computing of model(NCM) in the MSB blockchain, Finally large amounts of simulations manifest the proposed master-slave blockchain scheme is feasible, extendible and suitable for pervasive computing especially in the 5G generation environment, and can apply in the DRM-related applications.
Automatic photobook: focusing on image selection and image layout based on content and composition (2013)

In this paper, we present improvements to image selection and image layout for automatic photobook generating algorithms. These improvements are designed to help the user easily create a photo album, which matches the user preferences and strengthens the aesthetic quality of the photobook. Image content, composition, and metadata are utilized to determine the set of images being selected, and to suggest the layout of each page.
A Rheometer for Characterizing Polymer Melts and Suspensions in Shear Creep and Recovery Experiments (1985)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. J. P. Franck; A Rheometer for Characterizing Polymer Melts and Suspensions in Shear Creep and Recovery Experiments. J. Rheol. 1 December 1985; 29 (6): 833–850. https://doi.org/10.1122/1.549833 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
ChemInform Abstract: Electrical Transport Properties and Defect Structure of SrFeCo0.5Ox. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Robust ICP Registration Algorithm Extended by M-estimation. (2001)

An extension of the ICP (Iterative Closest Point) registration algorithm based on modified M-estimation for realization of robustness against outlying gross noise in two point data sets. The proposed algorithm is utilized to obtain a transformation consisting of rotation and translation parameters in order to perform the best fit between the data sets. An objective function which includes independent residual components for each of xyz coordinates is defined to evaluate the fit between the data sets, taking account of distribution of the outlying noise, which occurs due to occlusion, shadowing, or highlighting in measurement. The approach is based on modifid M-estimation through an iterative procedure for optimization of the transform for correspondence. Some fundamental experiments utilizing real data of 2D and 3D measurement show effectiveness of the proposed method.
Heterogeneity of the T Cell Response to Immunodominant Determinants Within Hen Eggwhite Lysozyme of Individual Syngeneic Hybrid F1 Mice: Implications for Autoimmunity and Infection (1998)

Hybrid F1 mice derived from inbred parental mouse strains are extensively used as animal models of human autoimmune diseases and transplantation. It is generally believed that with regard to immunologic studies, hybrid F1 mice behave in a consistent manner, equivalent to any other inbred mouse strain. In this study, we report that in comparison to inbred parental strains, individual hybrid F1 mice revealed a broad heterogeneity of proliferative response to the immunodominant determinants within hen eggwhite lysozyme (HEL). Of five parental strains tested, individual mice of three strains responding to only a few dominant HEL determinants (B6, BALB/c, and B10.PL) showed quite homogeneous patterns of response, whereas two mouse strains responsive to several determinants of HEL revealed either relative homogeneity (CBA/J mice) or heterogeneity (SJL mice) of response. However, in SJL mice, responses to major, dominant determinants of HEL were quite consistent. On the contrary, regardless of the consistency of response of parental strains, all three of F1 mice [[B6 x BALB/c]F1, [B6 x CBA/J]F1, and [SJL x B10.PL]F1] revealed significantly greater heterogeneity of response, which even involved the major, dominant determinants of HEL. We attribute the above heterogeneity of response to the competitive as well as aleatory nature of the interaction between various factors, including the coexistence of different MHC (parental as well as hybrid MHC) molecules, determinant capture, and the T cell repertoire. These results have important implications for studies on autoimmunity, infection, and vaccine design in human populations, where heterozygosity is the norm rather than the exception.
Development of a Rapid Immunodiagnostic Test for <i>Haemophilus ducreyi</i> (2002)

Haemophilus ducreyi is the etiologic agent of chancroid, a sexually transmitted disease that increases the rate of transmission of human immunodeficiency virus. Chancroid ulcerations are difficult to distinguish from those produced by syphilis and herpes. Diagnosis based solely on clinical grounds is inaccurate, and culture is insensitive. Highly sensitive PCR has largely superseded culture as the preferred method of laboratory diagnosis; however, neither culture nor PCR is feasible where chancroid is endemic. We developed a rapid (15-min) diagnostic test based on monoclonal antibodies (MAbs) to the hemoglobin receptor of H. ducreyi, HgbA. This outer membrane protein is conserved in all strains of H. ducreyi tested and is required for the establishment of experimental human infection. MAbs to HgbA were generated and tested for cross-reactivity against a panel of geographically diverse strains. Three MAbs were found to be unique and noncompetitive and bound to all strains of H. ducreyi tested. Using an immunochromatography format, we evaluated the sensitivity and specificity of the test using geographically diverse strains of H. ducreyi, other Haemophilus strains, and other bacteria known to superinfect genital ulcers. All H. ducreyi strains were positive, and all other bacteria were negative, resulting in a specificity of 100%. The minimum number of CFU of H. ducreyi detected was 2 x 10(6) CFU, and the minimum amount of purified HgbA protein detected was 8.5 ng. Although this level of sensitivity may not be sufficient to detect H. ducreyi in all clinical specimens, further work to increase the sensitivity could potentially make this a valuable bedside tool in areas where chancroid is endemic.
Predicting Machine Availabilities in Desktop Pools (2006)

This paper describes a study of predicting machine availabilities and user presence in a pool of desktop computers. The study is based on historical traces collected from 32 machines, and shows that robust prediction accuracy can be achieved even in this highly volatile environment. The employed methods include a multitude of classification methods known from data mining, such as Bayesian methods and support vector machines. Further contribution is a time series framework used in the study which automates correlations search and attribute selection, and allows for easy reconfiguration and efficient prediction. The results illustrate the utility of prediction techniques in highly dynamic computing environments. Potential applications for proactive management of desktop pools are discussed
Review of the Toxicology of Mineral Spirits (2008)

This review of the toxicology of mineral spirits covers studies of the major classes of mineral spirits and several toxicologically important mineral spirit constituents. This review cites data from numerous previously unpublished animal toxicology studies conducted on mineral spirits during the past 30 years, expanding the existing database on the toxicology of this group of hydrocarbon solvents. The data can be used to better evaluate the potential effects associated with exposure to these materials, including health and environmental reviews such as the U.S. Environmental Protection Agency High Production Volume (HPV) chemical program and the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) program. The majority of animal toxicology studies in the available literature were conducted on mineral spirits categorized as ASTM D235 Type I Class A (149 degrees C to 213 degrees C boiling range; 8% to 22% aromatics) and demonstrate that Type I Class A mineral spirits have a low order of acute toxicity and do not produce significant systemic effects. Some additional studies conducted with ASTM D235 Type II Class C mineral spirits (177 degrees C to 213 degrees C boiling range; < 2% aromatics) suggest that Type II Class C mineral spirits have similar toxicity to Type I Class A mineral spirits, though there is some evidence that Type II, Class C mineral spirits have a lesser degree of central nervous system (CNS) effects than the higher aromatic containing Type I Class A materials. In addition, toxicity data on selected chemical constituents of mineral spirits (e.g., n-nonane, n-decane, n-undecane) indicate that these chemicals have similar toxicological properties to mineral spirits. Overall, the data showed that mineral spirits have a low order of acute toxicity and do not appear to produce toxicologically relevant systemic effects. Ongoing studies are evaluating the concerns associated with chronic low-level exposure and central nervous system effects.
A MEMS-Based Flow Rate and Flow Direction Sensing Platform with Integrated Temperature Compensation Scheme (2009)

This study develops a MEMS-based low-cost sensing platform for sensing gas flow rate and flow direction comprising four silicon nitride cantilever beams arranged in a cross-form configuration, a circular hot-wire flow meter suspended on a silicon nitride membrane, and an integrated resistive temperature detector (RTD). In the proposed device, the flow rate is inversely derived from the change in the resistance signal of the flow meter when exposed to the sensed air stream. To compensate for the effects of the ambient temperature on the accuracy of the flow rate measurements, the output signal from the flow meter is compensated using the resistance signal generated by the RTD. As air travels over the surface of the cross-form cantilever structure, the upstream cantilevers are deflected in the downward direction, while the downstream cantilevers are deflected in the upward direction. The deflection of the cantilever beams causes a corresponding change in the resistive signals of the piezoresistors patterned on their upper surfaces. The amount by which each beam deflects depends on both the flow rate and the orientation of the beam relative to the direction of the gas flow. Thus, following an appropriate compensation by the temperature-corrected flow rate, the gas flow direction can be determined through a suitable manipulation of the output signals of the four piezoresistors. The experimental results have confirmed that the resulting variation in the output signals of the integrated sensors can be used to determine not only the ambient temperature and the velocity of the air flow, but also its direction relative to the sensor with an accuracy of ± 7.5° error.
Method for Determining Molar Concentrations of Metabolites in Complex Solutions from Two-Dimensional <sup>1</sup>H−<sup>13</sup>C NMR Spectra (2007)

One-dimensional (1D) (1)H nuclear magnetic resonance (NMR) spectroscopy is used extensively for high-throughput analysis of metabolites in biological fluids and tissue extracts. Typically, such spectra are treated as multivariate statistical objects rather than as collections of quantifiable metabolites. We report here a two-dimensional (2D) (1)H-(13)C NMR strategy (fast metabolite quantification, FMQ, by NMR) for identifying and quantifying the approximately 40 most abundant metabolites in biological samples. To validate this technique, we prepared mixtures of synthetic compounds and extracts from Arabidopsis thaliana, Saccharomyces cerevisiae, and Medicago sativa. We show that accurate (technical error 2.7%) molar concentrations can be determined in 12 min using our quantitative 2D (1)H-(13)C NMR strategy. In contrast, traditional 1D (1)H NMR analysis resulted in 16.2% technical error under nearly ideal conditions. We propose FMQ by NMR as a practical alternative to 1D (1)H NMR for metabolomics studies in which 50-mg (extract dry weight) samples can be obtained.
Abstract: Proposed Thermal Model for Deep Fresh Water in the Val Verde and Delaware Basins&nbsp; (1998)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Inhibition of Formation of<i>Escherichia coli</i>Mating Pairs by f1 and MS2 Bacteriophages as Determined with a Coulter Counter (1973)

The effect of male-specific filamentous deoxyribonucleic acid (f1) and isometric ribonucleic acid (MS2) bacteriophages on the formation of mating pairs in Escherichia coli conjugation was examined directly in the Coulter counter. When a sufficient multiplicity of infection (MOI) was used, the f1 phage immediately and completely inhibited the formation of mating pairs. On the other hand, the MS2 phage at a relatively high MOI also inhibited the formation of mating pairs significantly although not completey. The inhibitory effect of MS2 phage was dependent on the time of addition and the MOI used. At relatively low MOI (<20), the MS2 phage showed some inhibitory effect when added to a male culture prior to mixing with females, whereas no effect was observed when phages were added after mating pair formation had already commenced. At a high MOI (>400) MS2 phage disrupted the mating pairs already formed. Some preformed mating pairs were resistant to the high MOI of MS2 phages, however, and the "sensitive" (to high MOI) mating pairs seem to mature into "resistant" mating pairs as a function of time. We conclude that the tip of an F pilus is the specific attachment site for mating. The following process of mating pair formation has been formulated by deduction. (i) The sides of F pili weakly contact female cells, (ii) then the tips of F pili attach to the specific receptor sites to form initial mating pairs, and (iii) those pairs mature into mating pairs that are resistant to the high MOI of MS2 phages. The high MOI of MS2 prevents the first step, whereas f1 phages affect the second step-the binding between the tips of F pili and the receptor sites.
A 9-bit 1.8-GS/s pipelined ADC using linearized open-loop amplifiers (2015)

This paper presents a 9-bit 1.8-GS/s pipelined ADC. It employs open-loop residue amplifiers with a linearization technique, two time-interleaved CDACs with stage gain calibration, and a double-sampling architecture. This open-loop structure achieves high speed, low power and moderate resolution without any digital nonlinearity calibrations. The fabricated ADC in 65-nm CMOS technology achieves an SNDR of 51 dB and a FoM of 83 fJ/conversion-step while the sampling rate is 1.8 GS/s.
Labelling of octreotide using <sup>76</sup>Br‐prosthetic groups (2001)

Abstract A method for labelling the octapeptide octreotide ( D –Phe–Cys–Phe– D –Trp–Lys–Thr–Cys–Thr(ol)) with the positron emitting 76 Br ( T 1/2 =16 h) is presented. ϵ ‐Boc‐protected octreotide was conjugated to N –succinimidyl 4‐[ 76 Br]bromobenzoate 1 and N –succinimidyl 5‐[ 76 Br]bromo‐3‐pyridinecarboxylate 3 using microwave heating. The conjugates 4 and 5 were isolated in 50–55% radiochemical yield after the removal of the protecting Boc‐group. Compound 3 was synthesised from the corresponding trimethylstannyl‐precursor in 25% radiochemical yield. The synthesis of methyl‐4‐[ 76 Br] bromobenzimidate 8 in 40% radiochemical yield from the precursor methyl‐4‐trimethylstannylbenzimidate is also described. Experiments were performed to react 8 with Boc‐octreotide but no product was obtained. The binding‐properties of 76 Br‐conjugates 4 and 5 to meningiomas were investigated using frozen section autoradiography. Compound 5 showed better binding properties than 4 . Copyright © 2001 John Wiley & Sons, Ltd.
A membrane-bound monoheme cytochrome c551 of a novel type is the immediate electron donor to P840 of the Chlorobium vibrioforme photosynthetic reaction center complex. (1992)

A photosynthetic reaction center complex has been isolated from the green sulfur bacterium Chlorobium vibrioforme. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis reveals polypeptides with apparent molecular masses of 80, 40, 18, 15, 9, and 6 kDa. Only the 18-kDa polypeptide is stained with 3,3',5,5'-tetramethylbenzidine, a heme-specific reagent. Oxidized minus reduced difference spectra show the presence of approximately one heme/P840 and the presence of a cytochrome c551. Flash photolysis of P840 was followed by rereduction of P840+ and oxidation of cytochrome c551, both with a biphasic kinetic with t1/2 values of 7 and 50 microseconds. Using oligonucleotide probes derived from an N-terminal amino acid sequence of the 18-kDa polypeptide, a genomic clone was isolated. The sequence of the gene, which we designate cycA, predicts a single heme binding site (Cys-Asn-Lys-Cys-His). The 621-base pair open reading frame encodes an apoprotein of 22,858 Da with three predicted membrane-spanning alpha-helices. No extensive sequence similarity is found to other cytochromes. Northern blotting indicates that the cycA gene is transcribed as a monocistronic mRNA. Southern blotting shows the presence of only one cycA gene in the C. vibrioforme and Chlorobium tepidum genomes. The unique membrane-bound monoheme cytochrome c551 of C. vibriforme is assigned to a new class of c-type cytochromes. The implications for the current view of evolution of photosynthetic reaction center complexes are discussed.