gebhart/patrepeval huggingface dataset:
Enantioselective Permeation through Membranes of Chiral Helical Polymers Prepared by Depinanylsilylation of Poly(diphenylacetylene) with a High Content of the Pinanylsilyl Group (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTEnantioselective Permeation through Membranes of Chiral Helical Polymers Prepared by Depinanylsilylation of Poly(diphenylacetylene) with a High Content of the Pinanylsilyl GroupMasahiro Teraguchi, Jun-ichi Suzuki, Takashi Kaneko, Toshiki Aoki, and Toshio MasudaView Author Information Graduate School of Science and Technology, Niigata University, Ikarashi 2−8050, Niigata 950-2181, Japan, Center for Transdisciplinary Research, Niigata University, Ikarashi 2-8050, Niigata 950-2181, Japan, and Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan Cite this: Macromolecules 2003, 36, 26, 9694–9697Publication Date (Web):November 21, 2003Publication History Received3 October 2003Revised6 November 2003Published online21 November 2003Published inissue 1 December 2003https://doi.org/10.1021/ma035493hCopyright © 2003 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views879Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (76 KB) Get e-AlertscloseSUBJECTS:Conformation,Copolymerization,Interface engineering,Membranes,Polymers Get e-Alerts
Dysregulation of Epidermal Growth Factor Receptor in Actinic Keratosis and Squamous Cell Carcinoma (2014)

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its correct function is required for normal skin development and homeostasis, while dysregulation of EGFR signalling results in cellular hyper-proliferation and defects in differentiation, leading to impaired wound healing, the development of psoriasis-like lesions, structural and functional defects of hair follicles and tumourigenesis. Actinic keratosis, which is also known as solar keratosis, develops in sun-exposed areas of the skin. These are often called 'premalignant lesions' and are said to represent early squamous cell carcinoma (SCC) in situ, although debate over their classification continues. Anti-EGFR therapies have been approved for the treatment of several malignancies and are undergoing trials for others [1], including advanced cutaneous squamous cell carcinoma (CSCC). However, a number of questions remain regarding the treatment of CSCC with anti-EGFR inhibitors. A lower number of CSCC tumours are EGFR positive in comparison to other types of tumours, such as head and neck SCC (HNSCC), and it has been suggested that patients should be selected on the basis of high tumour EGFR expression. However, there are reports of patients with tumours showing no EGFR-positive staining responding to anti-EGFR therapy. EGFR is an oncogenic driver in many tumours. Does it drive the transformation of actinic keratosis to a tumourigenic phenotype? Many such questions remain, and here, we discuss the role of EGFR in SCC and its functions during the different stages of skin cancer development.
Micro-sized Fourier spectrometer (2002)

We present a miniaturized Fourier transform spectrometer based on optical micro-electro-mechanical system (OMEMS) technology. The spectrometer is a Michelson interferometer with one scanning mirror. An electrostatic comb drive actuator moves the mirror. The measured resolution of the spectrometer is 6 nm at a wavelength of 633 nm. In addition, we propose a method to integrate micro-optical components, like cylindrical lenses and beamsplitters, into the silicon chip with the actuated mirror.
An Early Ethylene Up-regulated Gene Encoding a Calmodulin-binding Protein Involved in Plant Senescence and Death (2000)

35S-Labeled calmodulin (CaM) was used to screen a tobacco anther cDNA library. A positive clone (NtER1) with high homology to an early ethylene-up-regulated gene (ER66) in tomato, and an Arabidopsis homolog was isolated and characterized. Based on the helical wheel projection, a 25-mer peptide corresponding to the predicted CaM-binding region of NtER1 (amino acids 796-820) was synthesized. The gel-mobility shift assay showed that the peptide formed a stable complex with CaM only in the presence of Ca(2+). CaM binds to NtER1 with high affinity (K(d) approximately 12 nm) in a calcium-dependent manner. Tobacco flowers at different stages of development were treated with ethylene or with 1-methylcyclopropene for 2 h before treating with ethylene. Northern analysis showed that the NtER1 was rapidly induced after 15 min of exposure to ethylene. However, the 2-h 1-methylcyclopropene treatment totally blocked NtER1 expression in flowers at all stages of development, suggesting that NtER1 is an early ethylene-up-regulated gene. The senescing leaves and petals had significantly increased NtER1 induction as compared with young leaves and petals, implying that NtER1 is developmentally regulated and acts as a trigger for senescence and death. This is the first documented evidence for the involvement of Ca(2+)/CaM-mediated signaling in ethylene action.
Low-Molecular-Weight Heparins for Acute Coronary Syndromes: An Emergency Medicine Perspective (1999)

Patients with chest pain represent one of the largest and most challenging populations for emergency departments to treat. Diagnostic and treatment modalities implemented in the emergency department are associated with significant clinical outcomes and financial implications. Critical pathways are being developed to increase the speed and efficiency with which these patients are managed. Of particular importance is the evolving role of low-molecular-weight heparins, which have both clinical and economic advantages over unfractionated heparins in treating unstable angina and non-Q wave myocardial infarction.
Peptide-containing nerves in the human pregnant uterine cervix: an immunohistochemical study exploring the effect of RU 486 (mifepristone) (1990)

The presence of several neuropeptides (neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), substance P (SP), galanin (GAL), enkephalin (ENK), somatostatin (SOM) was established in the early pregnant human cervix using indirect immunofluorescence immunohistochemistry. Several peptides (VIP, NPY, CGRP, GAL) were present both in free nerves among smooth muscle cells and around blood vessels. Others (SP, SOM) were only seen as single varicosities among smooth muscle cells. Randomized treatment of patients with RU 486 (mifepristone) prior to surgical sampling revealed no clearcut differences in peptide immunoreactivities. After RU 486 treatment, however, there was a tendency towards a decrease of NPY- and VIP-immunoreactivity, and an increase of CGRP-immunoreactivity.
Extracorporeal (“ex vivo”) connection of pig kidneys to humans. I. Clinical data and studies of platelet destruction (1996)

The pioneering experiment by Welsh et al. (Immunological Lett 1991:29:167-170) connecting a pig kidney to the human circulation has been repeated in a modified manner. Two volunteer dialysis patients were pretreated by daily plasmapheresis on days -2,-1, and 0 to remove the naturally occurring anti-pig xenoantibodies. The anti-pig lymphocytotoxic liters were reduced from 1:8 to 1:2 in patient 1 and from 1:8 to 1:1 in patient 2. No steroids or immunosuppressive drugs were administrated before or during the experiments. A sterile pig kidney was extracorporeally ("ex vivo") connected to the patients a/v fistula using an arterial and a venous pump similar to a dialysis. The two experiments gave different results. In the first experiment the perfusion pressure was kept at 100 mmHg for the initial 25 min by reducing the pump speed until the minimum blood flow of 30 ml/min was reached. Thereafter, the pressure rose continuously and the experiment was terminated at 65 min at a perfusion pressure of 200 mmHg. The patient did not feel any discomfort during the perfusion. In the second experiment, a stable blood flow of 200 ml/min was reached at a pressure of 100 mmHg after a few minutes. The perfusion was terminated at 15 min when the patient developed chest and abdominal pain, hypotension, and electrocardiographic signs of myocardial ischemia. The patient recovered quickly. In the first experiment, small volumes of clear urine was produced until the pressure rose above 100 mmHg, which resulted in hematuria. In the second experiment clear urine (4 ml/min) was produced. (51)Chromium clearance values were after 15 min <1 ml/min for kidney 1 and 12 ml/min (8 ml/min/100 g) for kidney 2. A drastic reduction in platelet count (128 to 48 and 64 to 8 × 10(9)/1, respectively) during the passage through the kidney was found in blood samples collected simultaneously before and after the organ. No change in hemoglobin values and leucocyte counts were found. Light- and electron-microscopical analysis of the kidney tissues revealed for kidney 1 focal areas with obliteration of the glomerular and peritubular capillaries by platelets and PMN cells and severe damage of the endothelial cells comparable to a picture of a hyperacute rejection. In kidney 2, all vessels were patent but in the capillaries large amount of membrane fragments were detected by electron microscopy and a discrete damage of the endothelial cells were seen in some segments. No intact platelets were present in the vascular tree. These human experiments support the hypothesis that hyperacute rejection of pig to human xenografts is delayed in time by removal of the preformed anti-pig xenoantibodies. A new finding was a very rapid destruction of platelets occurring in the kidney of patient 2 who had very low liters of xenoantibodies. The humoral immune response is described in detail in an accompanying paper (Rydberg et al., this issue).
Microcapsules containing suspensions of carbon nanotubes (2009)

Single-walled nanotubes (SWNTs) suspended in chlorobenzene (PhCl) and ethyl phenylacetate (EPA) were incorporated into microcapsules using an in situemulsification polymerization of urea-formaldehyde; the capsules release the SWNTs upon mechanical rupture.
On the mechanism of<i>Wolbachia</i>‐induced cytoplasmic incompatibility: Confronting the models with the facts (2003)

The endocellular bacterium Wolbachia manipulates the reproduction of its arthropod hosts for its own benefit by various means, the most widespread being cytoplasmic incompatibility (CI). To date, the molecular mechanism involved in CI has not been elucidated. We examine here three different CI models described in previous literature, namely, the "lock-and-key", "titration-restitution" and "slow-motion" models. We confront them with the full range of CI patterns discovered so far, including the most complex ones such as multiple infections, asymmetrical and partial compatibility relationships and the existence of Wolbachia variants that can rescue the host from CI but not induce it. We conclude that the lock-and-key model is the most parsimonious of the models and fits the observations best. The two other models cannot be categorically invalidated, but they encounter some difficulties that make additional hypotheses necessary.
Combating Resistance to Anti-IGFR Antibody by Targeting the Integrin β 3-Src Pathway (2013)

Increased Src activation through integrin ανβ3 confers considerable resistance against anti-IGF-1R mAb-based therapies in HNSCC and NSCLC cells. Dual targeting of the IGF-1R pathway and collateral integrin β3-Src signaling module may override this resistance.
Second Hip Fracture in Older Men and Women (2007)

Among survivors of an initial hip fracture, the incidence of a second hip fracture is substantial. Older age and functional status may be important predictors of a second hip fracture. There seems to be adequate time between the first and second hip fractures for interventions that may reduce second hip fractures.
Arabidopsis E2Fc Functions in Cell Division and Is Degraded by the Ubiquitin-SCF <sup>AtSKP2</sup> Pathway in Response to Light (2002)

Selective ubiquitin-mediated proteolysis through the cell cycle controls the availability, and therefore the activity, of several cell proliferation proteins. E2F transcription factors play distinct roles in both proliferating and differentiated cells by regulating gene expression. Here, we report that Arabidopsis AtE2Fc is regulated by a balance between gene expression and ubiquitin-proteasome proteolysis. AtE2Fc degradation implicates the function of the E3 ubiquitin-ligase Skp1, Cullin, F-box (SCF(AtSKP2)) complex and seems to be dependent on cyclin-dependent kinase phosphorylation. In addition, we found that AtE2Fc degradation is triggered by light stimulation of dark-grown seedlings. Interestingly, the auxin response mutant axr1-12, in which RUB1 modification of the SCF component CUL1 is impaired, shows increased AtE2Fc protein levels, suggesting a dysfunction in the control of AtE2Fc stability. Likewise, overexpression of a stable form of the AtE2Fc protein negatively affects cell division and increases cell size. These effects are mediated, at least in part, by downregulating the cell cycle gene AtCDC6. The negative role of AtE2Fc in gene expression is further supported by the fact that AtE2Fc interacts with plant retinoblastoma-related protein, suggesting that AtE2Fc might form part of a repressor complex. We propose that AtE2Fc might play a role in cell division and during the transition from skotomorphogenesis to photomorphogenesis.
Statistical Inference and Reverse Engineering of Gene Regulatory Networks from Observational Expression Data (2012)

In this paper, we present a systematic and conceptual overview of methods for inferring gene regulatory networks from observational gene expression data. Further, we discuss two classic approaches to infer causal structures and compare them with contemporary methods by providing a conceptual categorization thereof. We complement the above by surveying global and local evaluation measures for assessing the performance of inference algorithms.
Video annotation and navigation on mobile devices (2012)

The growing ease of capturing and playing back videos using mobile devices demands the investigation of alternatives for improving the user experience, for instance by taking advantage of the expanding culture of end-user content generation. Advances in terms of end-user media capture and media combination aim at enriching and facilitating the authoring experience. This work explores the generation of textual annotations on videos played on mobile device: the approach is to offer an application that allows associating annotations to a navigation line decorated with frames that are representative of the points of interest. The aims is to improve the user experience of video annotation by allowing users to to find interesting points intuitively. Experiments with users identified of new issues, even though the application was considered easy to use.
Fingerprint identification using the directions field (1996)

Optical-digital systems dedicated to the identification of fingerprints using the spatial spectrum and the directions field are discussed. For constructing the directions field, the proposed optical configuration uses a coherent correlator with a spatial filter consisting of sectional diffraction gratings. It is shown that the analysis based on the directions field is favoured. It is also shown that in analysing fingerprints using the Fourier-spectrum, it is only the information on the angular spectrum distribution that appears to be essential, whereas the information related to the radial spectrum distribution is abundant.
Intelligent real-time pressure tracking system using a novel hybrid control scheme (2017)

In this paper, a novel hybrid control scheme is proposed to improve the control performance in a real-time pressure tracking system using fast on-off solenoid valves. In this novel hybrid control scheme, an original approach named Time Interlaced Modulation (TIM) is developed to replace the traditional Pulse Width Modulation (PWM) approach. Besides using TIM, a new switching method which is referred as seven possible control modes is designed to ensure the proper switching states of the valves. Moreover, a controller with field programmable gate array (FPGA) is chosen to guarantee the real-time implementation of the control algorithm. All the simulations and experimental results implemented on FPGA verify the feasibility of the hybrid control scheme.
Genome-Wide Association Study in Dachshund: Identification of a Major Locus Affecting Intervertebral Disc Calcification (2011)

Intervertebral disc calcification and herniation commonly affects Dachshund where the predisposition is caused by an early onset degenerative process resulting in disc calcification. A continuous spectrum of disc degeneration is seen within and among dog breeds, suggesting a multifactorial etiology. The number of calcified discs at 2 years of age determined by a radiographic evaluation is a good indicator of the severity of disc degeneration and thus serves as a measure for the risk of developing intervertebral disc herniation. The aim of the study was to identify genetic variants associated with intervertebral disc calcification in Dachshund through a genome-wide association (GWA) study. Based on thorough radiographic examinations, 48 cases with ≥ 6 disc calcifications or surgically treated for disc herniation and 46 controls with 0-1 disc calcifications were identified. GWA using the Illumina CanineHD BeadChip identified a locus on chromosome 12 from 36.8 to 38.6 Mb with 36 markers reaching genome-wide significance (P(genome) = 0.00001-0.026). This study suggests that a major locus on chromosome 12 harbors genetic variations affecting the development of intervertebral disc calcification in Dachshund.
Two-dimensional optical accelerometer based on commercial DVD pick-up head (2006)

This study develops a low-cost, highly sensitive two-dimensional optical accelerometer based on a commercially available DVD optical pick-up head. Vibrations of the structure of interest cause a change in the angle of the seismic mass within the accelerometer. The relative movement between the seismic mass and the base produces a change in the distribution of a focused light spot on the surface of a four-quadrant photodetector. The resulting change in the output of the voltage signals by the photodetector is then used to calculate the corresponding acceleration of the base. The experimental results indicate that the resonant frequencies of the accelerometer in the X- and Y-axis directions are 92.75 Hz and 92.87 Hz, respectively. Furthermore, the useful frequency range of the accelerometer is found to be approximately 20% of its resonant frequency. The sensitivities of the accelerometer in the X- and Y-axis directions are 22.9 V/g and 21.3 V/g, respectively. Finally, the noise equivalent acceleration (NEA) of the accelerometer is found to be less than 30 µg Hz−1/2 over the frequency range 0.5–50 Hz.
Implementing Register Files for High-Performance Microprocessors in a Die-Stacked (3D) Technology (2006)

3D integration is a new technology that greatly increases transistor density while providing faster on-chip communication. 3D integration stacks multiple die connected with a very high-density and low-latency interface which provides increased device density and the ability to place and route in the third dimension. While past studies have explored 3D integrated on-chip caches, this research explores the implementation of register files, which have very different capacity and bandwidth requirements. Partitioning the register file across multiple die reduces the lengths of many critical wires, which provides both latency and energy benefits. In particular, a 3D implementation of 256-entry physical register file in a two-die stack achieves a 24.1% latency improvement with a simultaneous energy reduction of 58.5%, while a four-die version achieves a 36.0% latency improvement with a 58.2% energy reduction. Our results demonstrate that 3D integration is a promising approach for improving both the performance and power of wire-dominated circuits
ACTOMYOSIN CONTENT OF THE HUMAN PLACENTA (1974)

Summary The total soluble protein and the concentration of the contractile protein actomyosin were estimated in the human placenta at varying stages of gestation. As maturity and differentiation of the placenta occurred the proteins increased in concentration. The actomyosin was thought to be present in the smooth muscle fibres in the chorionic plate, and related to the placental vessel walls. The contractile property of the smooth muscle and the demonstration of contractile protein suggested that they play an active role in the dynamics of placental circulation.
Crystal Structure of a Mammalian Voltage-Dependent <i>Shaker</i> Family K <sup>+</sup> Channel (2005)

Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase beta subunit of the kind that can regulate mammalian Kv channels in their native cell environment. The activation gate of the pore is open. Large side portals communicate between the pore and the cytoplasm. Electrostatic properties of the side portals and positions of the T1 domain and beta subunit are consistent with electrophysiological studies of inactivation gating and with the possibility of K+ channel regulation by the beta subunit.
Differential transcriptome and development of human peripheral plasma cell subsets (2019)

Human antibody-secreting cells (ASCs) triggered by immunization are globally recognized as CD19loCD38hiCD27hi. Yet, different vaccines give rise to antibody responses of different longevity, suggesting ASC populations are heterogeneous. We define circulating-ASC heterogeneity in vaccine responses using multicolor flow cytometry, morphology, VH repertoire, and RNA transcriptome analysis. We also tested differential survival using a human cell-free system that mimics the bone marrow (BM) microniche. In peripheral blood, we identified 3 CD19+ and 2 CD19- ASC subsets. All subsets contributed to the vaccine-specific responses and were characterized by in vivo proliferation and activation. The VH repertoire demonstrated strong oligoclonality with extensive interconnectivity among the 5 subsets and switched memory B cells. Transcriptome analysis showed separation of CD19+ and CD19- subsets that included pathways such as cell cycle, hypoxia, TNF-α, and unfolded protein response. They also demonstrated similar long-term in vitro survival after 48 days. In summary, vaccine-induced ASCs with different surface markers (CD19 and CD138) are derived from shared proliferative precursors yet express distinctive transcriptomes. Equal survival indicates that all ASC compartments are endowed with long-lived potential. Accordingly, in vivo survival of peripheral long-lived plasma cells may be determined in part by their homing and residence in the BM microniche.