gebhart/patrepeval huggingface dataset:
Establishment and characterization of hamster cell lines transformed by restriction endonuclease fragments of adenovirus 5 (1984)

We have established a library of hamster cells transformed by adenovirus 5 DNA fragments comprising all (XhoI-C, 0 to 16 map units) or only a part (HindIII-G, 0 to 7.8 map units) of early region 1 (E1: 0 to 11.2 map units). These lines have been analyzed in terms of content of viral DNA, expression of E1 antigens, and capacity to induce tumors in hamsters. All cells tested were found to express up to eight proteins encoded within E1A (0 to 4.5 map units) with apparent molecular weights between 52,000 (52K) and 25K. Both G and C fragment-transformed lines expressed a 19K antigen encoded within E1B (4.5 to 11.2 map units), whereas an E1B 58K protein was detected in C fragment-transformed, but not G-fragment-transformed, lines. No clear distinction could be drawn between cells transformed by HindIII-G and by XhoI-C in terms of morphology or tumorigenicity, suggesting that the E1B 58K antigen plays no major role in the maintenance of oncogenic transformation, although possible involvement of truncated forms of 58K cannot be ruled out. Sera were collected from tumor-bearing animals and examined for ability to immunoprecipitate proteins from infected cells. The relative avidity of sera for different proteins was characteristic of the cell line used for tumor induction, and the specificity generally reflected the array of viral proteins expressed by the corresponding transformed cells. However, one notable observation was that even though all transformed lines examined expressed antigens encoded by both the 1.1- and 0.9-kilobase mRNAs transcribed from E1A, tumor sera made against these lines only precipitated products of the 1.1-kilobase message. Thus, two families of E1A proteins, highly related in terms of primary amino acid sequence, appear to be immunologically quite distinct.
Hepatitis B Virus and Hepatitis Delta Virus (2001)

This chapter contains sections titled: Hepatitis B virus (HBV) Chronic hepatitis B Hepatitis delta virus (HDV)
[Isolation and purification of BMScs of GFP transgenic mouse using the method of adhering to cuture plastic in different time]. (2006)

The method of adhering to culture plastic in different time for cultivating and purifying BMSCs of GFP transgenic mice is effective. It is suitable to make the first exchange of total volume medium in 8-10 hours. The subcultured cell has the capacity for amplification and will probably be a seed cell for the research of tissue engineering and gene therapy.
The Status of Computer-Assisted Language Instruction (2013)

Opening Keynote Address, presented at the CALICO conference in Monterey in 1987.
Bis- and Tetrakis(organosilyl) Decatungstosilicate, [-SiW10O36(RSi)2O]4 and [-SiW10O36(RSiO)4]4: Synthesis and Structural Determination by Multinuclear NMR Spectroscopy and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (2000)

The high propensity of organosilanes towards polycondensation and reaction with nucleophilic moieties has facilitated the formation of new organic-inorganic hybrids based on the lacunary divacant heteropolyanion [γ-SiW10O36]8−. Depending on the experimental conditions two different types of derivatives were obtained with the general formula [γ-SiW10O36(RSi)2O]4− (1) (>90 % yield) and [γ-SiW10O36(RSiO)4]4− (2) (>85 % yield) (R=H (1 a, 2 a), vinyl (1 b), -C3H6OC(O)C(Me)=CH2 (1 c, 2 c), phenyl (1 d, 2 d)). The structures of the hybrid anions have been inferred from spectroscopic data, in particular from multinuclear (29Si and 183W) NMR solution studies and from MALDI-TOF mass spectrometry. Both species correspond to the grafting of an oxo-bridged siloxane unit onto the surface of the lacunary polyoxoanion.
The Playwright and the Atomic World (1961)

I obviously can have no special competence in the field of foreign policy. I only know what I read in the papers and the fact that I am a creative writer does not make my opinions either wiser or more persuasive than those of any other man. But it seems to me that there might be some good purpose in one of my profession expressing himself on this kind of problem. A certain awareness of attitudes outside our borders has been forced on me over the past ten years. My plays are regularly produced on the stages of Europe, Asia, Australia, and other areas. I have not traveled extensively abroad for some seven years now, but I do receive a steady mail from artists, producers, and audiences in foreign countries; there are visits and a steady correspondence with them and frequent newspaper reviews and articles concerning my work.
Dietary factors and breast cancer risk (1981)

As part of a case-control study in northern Alberta, Canada, 577 women aged 30-80 with breast cancer diagnosed during 1976-77 and a population-based age-stratified random sample of 826 disease-free female controls were questioned about certain aspects of their diet. Computing relative risks (RRs) by tertiles, significant increasing trends were found with more frequent consumption of beef (RRs of 1.0, 2.3, 1.5; test for trends, p less than 0.001), pork (RRs of 1.0, 1.6, 2.2; test for trend, p less than 0.001), and sweet desserts (RRs of 1.0, 1.3, 1.5; test for trend, p = 0.01). Elevated risks were also noted for use of butter at the table and for frying with butter or margarine, as opposed to vegetable oils. The association of total beef and pork consumption with breast cancer was not materially affected by controlling for age at first birth, family history of breast cancer, previous benign breast biopsy or socioeconomic status. Nor was the association reduced by controlling for ages of menarche and menopause, even though within the control series the intake of beef and pork reported in adult life was higher among those with a lower age at menarche or a older age at natural menopause.
Logically centralized? (2012)

Software Defined Networks (SDN) give network designers freedom to refactor the network control plane. One core benefit of SDN is that it enables the network control logic to be designed and operated on a global network view, as though it were a centralized application, rather than a distributed system - logically centralized. Regardless of this abstraction, control plane state and logic must inevitably be physically distributed to achieve responsiveness, reliability, and scalability goals. Consequently, we ask: "How does distributed SDN state impact the performance of a logically centralized control application?"
Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates. (2005)

The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing and is exacerbated by the human immunodeficiency virus (HIV) epidemic. The standard short-course regimen used for the treatment of tuberculosis is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing (DST) is necessary to select an appropriate treatment regimen. In this study, DST of 99 MDR-TB strains isolated in Thailand was performed using a drug-impregnated disc method. The results showed that 94.95% of the strains were susceptible to amikacin and kanamycin, 90.91% to ciprofloxacin and ofloxacin, 85.86% to para-aminosalicylic acid, and 78.79% to ethionamide.
Inhibition of HIV-1 infection by a CCR5-binding cyclophilin from Toxoplasma gondii (2003)

The activation of murine dendritic cells by Toxoplasma gondii has recently been shown to depend on a parasite protein that signals through the chemokine receptor CCR5. Here we demonstrate that this molecule, cyclophilin-18 (C-18), is an inhibitor of HIV-1 cell fusion and infection with cell-free virus. T gondii C-18 efficiently blocked syncytium formation between human T cells and effector cells expressing R5 but not X4 envelopes. Neither human nor Plasmodium falciparum cyclophilins possess such inhibitory activity. Importantly, C-18 protected peripheral blood leukocytes from infection with multiple HIV-1 R5 primary isolates from several clades. C-18 bound directly to human CCR5, and this interaction was partially competed by the beta-chemokine macrophage inflammatory protein 1 beta (MIP-1 beta) and by HIV-1 R5 gp120. In contrast to several other antagonists of HIV coreceptor function, C-18 mediated inhibition did not induce beta-chemokines or cause CCR5 downmodulation, suggesting direct blocking of envelope binding to the receptor. These data support the further development of C-18 derivatives as HIV-1 inhibitors for preventing HIV-1 transmission and for postexposure prophylaxis.
Phosphazo Compounds and their Use in Preparing Amides (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphazo Compounds and their Use in Preparing AmidesH. W. Grimmel, A. Guenther, and Jack F. MorganCite this: J. Am. Chem. Soc. 1946, 68, 4, 539–542Publication Date (Print):April 1, 1946Publication History Published online1 May 2002Published inissue 1 April 1946https://pubs.acs.org/doi/10.1021/ja01208a001https://doi.org/10.1021/ja01208a001research-articleACS PublicationsRequest reuse permissionsArticle Views726Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chiral Media for Capillary Electrophoresis (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChiral Media for Capillary ElectrophoresisTimothy J. WardCite this: Anal. Chem. 1994, 66, 11, 632A–640APublication Date (Print):June 1, 1994Publication History Published online6 June 2012Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ac00083a720https://doi.org/10.1021/ac00083a720research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Hydrovinylation Reaction:  A New Highly Selective Protocol Amenable to Asymmetric Catalysis (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationThe Hydrovinylation Reaction: A New Highly Selective Protocol Amenable to Asymmetric CatalysisNobuyoshi Nomura, Jian Jin, Haengsoon Park, and T. V. RajanBabuView Author Information Department of Chemistry, The Ohio State University 100 West 18th Avenue, Columbus, Ohio 43210 Cite this: J. Am. Chem. Soc. 1998, 120, 2, 459–460Publication Date (Web):January 3, 1998Publication History Received10 October 1997Published online3 January 1998Published inissue 1 January 1998https://pubs.acs.org/doi/10.1021/ja973548nhttps://doi.org/10.1021/ja973548nrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1698Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Group 15 compounds,Hydrocarbons,Ligands,Vinyl Get e-Alerts
Symbolic Execution with Interval Solving and Meta-heuristic Search (2012)

A challenging problem in symbolic execution is to solve complex mathematical constraints such as constraints that include floating-point variables and transcendental functions. The inability to solve such constraints limit the application scope of symbolic execution. In this paper, we present a new method to solve such complex math constraints. Our method combines two existing: meta-heuristic search and interval solving. Conceptually, the combination explores the synergy of the individual methods to improve constraint solving. We implemented the new method in the CORAL constraint-solving infrastructure, and evaluated its effectiveness on a set of publicly-available software from the aerospace domain. Results indicate that the new method can solve significantly more complex mathematical constraints than previous techniques.
Ferroelectric Liquid Crystal Spatial Light Modulators (1990)

This paper discusses the operating characteristics of a new class of spatial light modulators that utilize ferroelectric liquid crystals, and their application to building optoelectronic computing architectures.
Narrow beam 1.3 µm superluminescent diodewith butt-jointed selectively grown spot size converter (1997)

A narrow-beam superluminescent diode (SLD) has been developed using a butt-jointed selectively grown spot size converter and a newly designed absorption region. High output power and low spectral modulation have been achieved. The far field patterns for both the horizontal and vertical directions were as narrow as 10°. The coupling efficiency of output power into a flat-ended singlemode fibre (4 µm spot size) was as high as –1.9 dB without lenses.
Automated classification of candidate structures for computer-assisted structure elucidation (1988)

In computer-assisted structure elucidation, a large number of candidate structures for the unknown compound can be generated. A computer program designed to aid in the recognition of significant differences between these structures is described. The goal of the program is to group the candidates into meaningful classes with a minimum of input from the user; each class is distinguished by a substructure its members have in common. A computational approach is developed based on the combinatorial problem of set covering. The program evaluates its results using an information-theoretical criterion. An application of the program to a real-word structure problem is presented.
Maternal Immunity to Infectious Bovine Rhinotracheitis and Bovine Viral Diarrhea Viruses: Duration and Effect on Vaccination in Young Calves (1978)

The immune response to modified live-virus bovine viral diarrhea (BVD) vaccine and infectious bovine rhinotracheitis (IBR) vaccine was examined in calves that had received passive maternal antibodies to these viruses. Blood serum samples from vaccinated and control (nonvaccinated) calves were examined for more than 1 year to determine the rate of decline of passive anti-BVD and anti-IBR antibodies and the effect that vaccination had on these antibody titers. The control calves lost their antibodies to BVD and IBR viruses at the rate of one half their remaining antibody titer every 21 days. Calves serologically responded to BVD vaccine at a time when maternal antibody titers remained between 1:96 and 1:20. However, animals did not seroconvert to the IBR vaccine until maternal antibodies had decreased and become undetectable. Evidence is presented to show that although passive immunity will inhibit IBR vaccination, priming for a secondary response will occur so that on subsequent vaccination, at a time when maternal antibodies have disappeared, the animals will respond anamnestically to IBR vaccination.
The Relation between Immunology, Nutrition and Disease in Elderly People (1990)

Journal Article The Relation between Immunology, Nutrition and Disease in Elderly People Get access Ranjit Kumar Chandra Ranjit Kumar Chandra Department of Pediatric Research and Medicine, Health Sciences Centre, Memorial University of NewfoundlandSt John's, Newfoundland AIB 3V6, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Age and Ageing, Volume 19, Issue suppl_1, 1990, Pages S25–S31, https://doi.org/10.1093/ageing/19.suppl_1.S25 Published: 01 March 1990
Impact of Drawing Stress on the Tensile Strength of Oxide Glass Fibers (2010)

The sources of the tensile strength and fracture of both continuous glass fibers and discontinuous wool fibers are explored in terms of structural anisotropy, enthalpy relaxation, defect orientation, and surface inhomogeneities. The fibers are spun from the E‐glass and the basaltic glass melts, respectively. It is revealed that axial stress plays an important role in enhancing the strength of the oxide glass fibers. The increase of axial stress leads to the increase of both the structural anisotropy and the defect (flaws, bubbles, striae, etc.) orientation, and hence the increase of the tensile strength. Besides the axial stress, the increase of the cooling rate also increases the tensile strength of the continuous fibers. These findings are further substantiated by annealing experiments on both continuous and wool fibers below T g . The onset annealing temperature of the tensile strength decay is close to that of the anisotropy relaxation of the continuous fibers. The relative contributions of the different factors to the fiber strength are schematically scaled with the help of the sub‐ T g annealing.
DAME: an expert microprocessor-based-systems-designer. An overview and status report (2002)

The component library and knowledge base in DAME (design automation of microprocessor-based systems) is presented. A notation is developed to allow the complete specification and the modeling of the static and temporal behaviors of signals found in these components. Knowlege representation using frames in a hierarchical structure is presented, together with some typical rules used for the design process. Examples of the hierarchy, frames, and rules to design interfaces between microprocessor and memory components are illustrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Nanosensors Based on Responsive Polymer Brushes and Gold Nanoparticle Enhanced Transmission Surface Plasmon Resonance Spectroscopy (2004)

Swelling (and shrinking) of poly(2-vinylpyridine), P2VP, polymer brushes, caused by pH changes, could be readily monitored by transmission surface plasmon resonance, T-SPR, spectroscopy. Gold nanoparticles attached to the P2VP polymer brushes dramatically enhanced the pH-induced shift in the T-SPR absorption spectra. (A 50 nm shift of the absorption maximum of the T-SPR spectrum of the supporting gold nanoislands was observed upon changing the pH from 5.0 to 2.0, corresponding to a swelling of the polymer brushes from 8.1 +/- 0.7 to 24.0 +/- 2.0 nm. Same shift in the opposite direction was observed upon changing the pH from 2.0 to 5.0.)
Stability boundaries of liquid-propelled elastic space vehicles withsloshing. (1966)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Molecular Target-Guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine (2007)

A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM) with rapidly increasing export rates of TCM products from China to Europe and USA. This led to a national decision of the Chinese government to implement a "Plan for the Modernization of Chinese Medicine". Concerning the use of Chinese medicinal herbs, two major directions can be distinguished. One field is phytochemistry and pharmacognosy. Secondary metabolites isolated from Chinese plants can be easily subjected to pharmacological, molecular biological, and pharmacogenomic analyses using methods of modern cell and molecular biology as exemplified for camptothecin from Camptotheca acuminata in the present review. The second field of interest is phytomedicine. Standardized international quality guidelines help to improve quality, safety and efficacy of Chinese medicinal herbs. Sustainability of natural products from TCM can be reached by breeding high-yield varieties or by biotechnological approaches. In the long term, natural products from TCM can contribute to the development of molecular target-guided therapies and individualized treatment strategies.
Some Methods for SPECT Uniformity Correction and Their Evaluation (1985)

The importance of uniformity correction in the SPECT image quality cannot be overemphasized. An efficient interactive algorithm for the generation of uniformity correction coefficients has been developed by utilizing smoothing and window functions. An optimal number of counts required for SPECT uniformity correction has been analyzed. A relationship between SPECT uniformity information and image quality has been mathematically defined. These investigations have demonstrated the usefulness of smoothing and windowing for the uniformity correction. It has also been noticed that electronic or system noise is a dominating factor in the RME error after a certain limit in the number of counts of flood data.
Detection of benzene and other gases with an open-path, static Fourier-transform UV spectrometer (1998)

Releases of benzene and other gases have been detected and quantified using a novel optical, open-path instrument based on a deuterium light source and a static Fourier-transform spectrometer. The spectrometer uses Wollaston prisms to form an interferogram in the spatial domain that is recorded by use of a detector array. The instrument is designed to operate in the ultraviolet region of the spectrum between 200 and 270 nm, which coincides with strong absorption features in the spectra of many gases of environmental and health interest. Using the instrument with a 5-s measurement period provides a path-integrated concentration sensitivity to benzene of 2 parts in 10(6) times meter, which corresponds to a 20-parts in 10(9) detection limit over a typical path length of 100 m.