gebhart/patrepeval huggingface dataset:
Feasibility study of mesh networks for all-wireless offices (2006)

There is a fair amount of evidence that mesh (static multihop wireless) networks are gaining popularity, both in the academic literature and in the commercial space. Nonetheless, none of the prior work has evaluated the feasibility of applications on mesh through the use of deployed networks and real user traffic. The state of the art is the use of deployed testbeds with synthetic traces consisting of random traffic patterns.In this paper, we evaluate the feasibility of a mesh network for an all-wireless office using traces of office users and an actual 21-node multi-radio mesh testbed in an office area. Unlike previous mesh studies that have examined routing design in detail, we examine how different office mesh design choices impact the performance of user traffic. From our traces of 11 users spanning over a month, we identify 3 one hour trace periods with different characteristics and evaluate network performance for them. In addition, we consider different user-server placement, different wireless hardware, different wireless settings and different routing metrics.We find that our captured traffic is significantly different from the synthetic workloads typically used in the prior work. Our trace capture and replay methodology allows us to directly quantify the feasibility of office meshes by measuring the additional delay experienced by individual transactions made by user applications. Performance on our mesh network depends on the routing metric chosen, the user-server placement and the traffic load period. The choice of wireless hardware and wireless settings has a significant impact on performance under heavy load and challenging placement. Ultimately we conclude that for our traces and deployed system, under most conditions, all-wireless office meshes are feasible. In most cases, individual transactions incur under 20ms of additional delay over the mesh network. We believe this is an acceptable delay for most applications where a wired network to every machine is not readily available. We argue that our results are scalable to a network of over 100 users.
A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of <i>flexed-tail</i> (<i>f/f</i>) mice (2001)

We have studied the flexed-tail (f) mouse to gain insight into mammalian mitochondrial iron metabolism. Flexed-tail animals have axial skeletal abnormalities and a transient embryonic and neonatal anemia characterized by pathologic intramitochondrial iron deposits in erythrocytes. Mitochondrial iron accumulation is the hallmark of sideroblastic anemias, which typically result from defects in heme biosynthesis or other pathways that lead to abnormal erythroid mitochondrial iron utilization. To clone the f gene, we used positional cloning techniques, and identified a frameshift mutation in a mitochondrial transmembrane protein. The mutated gene, Sfxn1, is the prototype of a novel family of evolutionarily conserved proteins present in eukaryotes.
Molecular Imprinting Through van der Waals Interactions: Fluorescence Detection of PAHs in Water (1998)

Detection of polycyclic aromatic hydrocarbons (PAHs) is important since they are known to be carcinogenic. The feasibility of detection by chemical sensors by means of fluorescence spectroscopy is demonstrated. It is described how sensor layers are produced by being polymerized in the presence of PAHs—molecular imprinting is effected via non-covalent interactions as PAHs have no pronounced functionality—which leaves hollows optimized for particular PAHs when the imprinting PAHs are removed. Analyte inclusion in the optimized hollows is shown to lead to favorable selectivities and excellent sensitivity.
Clinical pharmacological studies of amoxycillin: effect of probenecid. (1979)

In a study of eight, healthy adult volunteers given 3 g amoxycillin with or without 1g probenecid, significantly higher peak plasma levels of amoxycilin were recorded in the presence (34.96 microgram/ml) of probenecid than in its absence (22.72 microgram/ml). When plasma levels were plotted against time the mean area under the curve was significantly greater for subjects given probenecid than for those given amoxycillin alone. These findings suggest that 3g amoxycillin plus 1g probenecid provide better bioavailability than 3g amoxycillin alone. The plasma levels obtained were several times higher than the minimun inhibitory concentrations (MICs) of most strains of gonococci. Plasma levels in excess of the MICs for most strains were maintained for eight hours with both regimens, but the higher levels in the presence of probenecid support the better clinical results previously reported with this regimen.
Quantifying construction claims using the differential cost method (1993)

In all construction claims there exist two hurdles which must be overcome before resolution can occur, i.e. entitlement and quantification. This paper addresses the latter issue (regarding productivity/impact claims) by initially presenting the differential method of quantification and then describing its application on a case study. Through this method the authors quantified a contractor's loss of productivity on a four-storey commercial building in western Canada. This was achieved by comparing productivity between a period of construction during which the contractor alleged concrete operations were completed under ‘normal’ conditions and a period when the contractor's productivity was affected by inclement weather. For proper application of this method, certain requirements must be met. The difficulty in satisfying these requirements frequently causes the result of the calculation to be suspect. The author's compliance with these requirements will be discussed.
Electrodeposition of platinum microparticles into polyaniline films with electrocatalytic applications (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrodeposition of platinum microparticles into polyaniline films with electrocatalytic applicationsKent M. Kost, Duane E. Bartak, Beth. Kazee, and Theodore. KuwanaCite this: Anal. Chem. 1988, 60, 21, 2379–2384Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ac00172a012https://doi.org/10.1021/ac00172a012research-articleACS PublicationsRequest reuse permissionsArticle Views1435Altmetric-Citations225LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lipopolysaccharide, capsule, and fimbriae as virulence factors among O1, O7, O16, O18, or O75 and K1, K5, or K100 Escherichia coli (1984)

K1, K5, and K100 Escherichia coli isolates of the lipopolysaccharide antigen types O1, O7, O16, O18, or O75, which had formerly been assigned to clonal groupings were compared with K? E. coli isolates and with laboratory-derived mutants defective in capsule or lipopolysaccharide synthesis. The amount of K1 capsule, the length distribution of the lipopolysaccharide, and the expression of type I and P fimbriae were determined. The clonal groupings were uniform with regard to these properties within each group but different from each other. Many of the K? strains differed from the clonal representatives. The results are interpreted with regard to the different diseases caused by each of these bacterial groups.
Inflammatory mediators potentiate pain induced by experimental tissue acidosis (1996)

Electrophysiological evidence from cutaneous nociceptors suggested a synergism between excitatory actions of inflammatory mediators (IM) and low pH. In human skin it is possible to induce constant ongoing pain with continuous infusion of acid buffer. This method was used to study the interaction with mediators of inflammation psychophysiologically. A skin area on the palmar forearm of 6 subjects (either gender, age 22-35 years) was continuously infiltrated with a phosphate buffered electrolyte solution (pH 5.2) using a motorized syringe pump that was adjusted so as to produce constant pain of about 20% on a visual analog scale (VAS; extending from 'no' to 'unbearable pain'). Pain was assessed on the VAS at 10-sec intervals; the rating was called up by means of an acoustic signal. An additional cannula was placed in the skin before the infusion of acidic buffer started. Injections of an acidic combination of IM (BK, 5-HT, HIS, PGE2) 0.2 ml were then given through the cannula at intervals of 10 min in a randomized double blind order of concentrations. The other arm was used for negative control, i.e. IM in neutral solution were injected into normal skin continuously infiltrated with a buffer solution at pH 7.4. The IM induced dose-dependent, transient burning pain on both arms-markedly more intense and prolonged, however, in the acidotic skin (P < 0.004, U-test). The difference corresponded to a 10-fold increase in algogenic potency with 10(-7) M IM, being smaller with 10(-6) and 10(-5) M concentration. The interaction between low pH and IM was mutual: additional injections of plain phosphate buffer (pH 5.2) into the acidotic skin were significantly more painful (20-fold) after application of IM than under control conditions. Thus, we tend to conclude that it is the inflammatory mediators that potentiate the algogenic effect of low pH rather than vice versa. Tissue acidosis appears as a dominant factor in inflammatory pain.
Recent developments in the growth, processing, and testing of rare-earth-doped YVO 4 single crystals (1994)

The production of the laser host material YVO<SUB>4</SUB> via high temperature solution growth (HTSG) is described as a facile alternative for producing optical quality crystals for research. The effects of dopant concentration on optical absorption properties in 0.7% and 3% Nd:YVO<SUB>4</SUB> crystals are discussed. The rare earth ions Ho<SUP>3+</SUP> and Er<SUP>3+</SUP> have been doped into YVO<SUB>4</SUB> with the HTSG method, and inaugural optical properties of Ho<SUB>0.04</SUB>Y<SUB>0.96</SUB>VO<SUB>4</SUB> are presented.
Radiation pattern of rectangular patch antenna with curved surface (2016)

In this paper, we analyze radiation pattern of a rectangular patch antenna with curved surface by means of mathematical approach. Aperture size of the curved patch is equivalently reduced in comparison with a flat surface patch antenna, so that its antenna gain slightly decreases and beam-width broadens. Because electrical size of patch is generally small, it is adequate to employ numerical calculation approach such as Method of Moment. However we try to employ analytical approach, Aperture Field Method, to the curved rectangular patch element. The radiation pattern is found to be expressed by Fresnel integral since phase distribution of main two slots can be approximated to quadratic shape.
Bringing life sciences to life. (1996)

A brief review of the status of space life sciences research is provided with an emphasis on the contributions this research has made to life here on Earth. Physiological effects of weightlessness are discussed along with methods of prevention or treatment. Several technologies are described which have resulted in advances in improved health care and in other industries. In addition, the impact of space life sciences research on women's health issues and on future space travel are discussed.
Is the Longleaf Type a Climax? (2013)

What is a climax? The commonly accepted definition is, a type of vegetation which has adapted itself over a long period to a set of environmental conditions, so completely that it is stabilized as long as those conditions remain unchanged. In a narrower sense, a climax type assumes adaptation to a given set of conditions excluding other conditions. The conditions excluded are those which would usually result in disturbance of this stability or equilibrium. These are; fire, under the conception that fire acts to destroy the stand; insects, when epidemic; destructive winds. The effect of imported diseases and insects, or of man's interference in lumbering, destroys the balance and the type may completely change. Climax types may therefore yield at any time to new conditions to which they are not adapted. Excluding the above factors, there would remain only the climatic and soil factors of site. These factors, isolated from the effects of the so-called destructive group, would finally establish a forest type in which the only surviving species would be those capable of enduring the shade of a forest cover during their establishment. This condition necessitates the elimination of fire, wind, insect epidemics and disease for periods longer than the life span of species which cannot endure shade. When, as with Douglas fir, this span is from 300 to 500 years, and the environmental conditions are such as to create extreme conflagration hazard at intervals of from 3 to io years, the establishment of climax types of more shade-enduring species, which are usually inferior in utility, is a pure accident. In the life span of the species, any factor, such as fire, which can be depended on to occur even once within that period, and create conditions favorable to its reproduction, may become the determining factor in its perpetuation as against shadeenduring or so-called climax types. The characteristics of such a relationship are that while fire is required (or its man-made substitute, lumbering) for the removal of the overwood shade and establishment of reproduction, the total exclusion of subsequent fires is equally necessary for survival of this reproduction. The distribution and composition of the forest types in such a region is, therefore, very irregular, much young growth is destroyed prematurely, and here and there a patch may finally attain the climax or shade-enduring type. If for any reason the normal or natural frequency of fire is increased so that its chance of occurrence on any given area becomes once in IO to i5 years, the only hope for survival of the tree species is ability to develop a fire resistant bark within such a period and the fact that the fires when they do occur will
Role of the Standard ‘Liver Function Tests’ in Current Clinical Practice (1989)

A prerequisite of current therapy in liver disease is precise diagnosis. The rapid increase in the number of tests available--immunological, virological, histological and radiological--testifies to this, and reflects the inadequacy of the 'standard' liver function tests (LFTs). The LFTs are, however, in contrast to these more sophisticated tests, observer independent and despite their lack of specificity, several characteristic patterns of abnormality can be recognised which direct the physician to the most appropriate definitive investigation. The cheapness and non-invasive nature of the LFTs makes them particularly appropriate for monitoring the course of liver diseases once the diagnosis has been established and this, together with screening for hepatotoxicity of newly developed drugs, is now their main role. A second generation of liver function tests based on the capacity of the liver to eliminate various test compounds may come closer to offering a true estimate of liver function. More accurate methods of measuring the various bilirubin fractions, particularly bilirubin conjugates may also become available in the near future and provide more sensitive tests of liver dysfunction.
A Ticket to Ride: Does Free Bus Travel Promote Active Ageing? ∗ (2010)

In April 2006, the English government introduced a policy granting free local bus travel to all those over 60. The rationale was that by encouraging bus use, the reform could help to support active lifestyles, tackle social exclusion, and maintain well-being amongst the older population. Measures of this type, which attempt to reduce the costs of old age, are receiving increased attention as populations grow older. This paper considers both the effect of the reform on travel behaviour, and the potential benefits for older people themselves, their families, and the state. Responses are estimated using a difference-in-difference-in-difference approach, exploiting both age and geographic variation in eligibility. Results show an increase in bus use on the intensive and extensive margins of travel, invariant to individual socioeconomic characteristics. Additional journeys represent new trips, with little substitution across modes. Effects upon broader aspects of behaviour are concentrated amongst activities most closely related to bus travel, including walking and perceived access to services. There are no statistically significant effects upon social participation, or short-run measures of health. Taken together, results indicate that responses to the reform are consistent with encouraging “active ageing”, but produced few spillovers upon outcomes not directly linked to transport.
Temperature sensor based on temperature and frequency dependence of graphene impedance (2018)

Abstract We studied the frequency and temperature dependence of the impedance of Si/SiO -substrate graphene. dc resistance is a weak non-monotonic temperature function at low temperature, whereas it exhibits a negative temperature characteristic at high temperature. The frequency dependence of the impedance implies that one should be concerned with the renormalization in the complete understanding of graphene impedance at radio frequencies. As an application, we designed a sensitive temperature sensor at the range .
Reactivity of 2-furylethylenes with nucleophilic groups and its biological significance (1987)

The paper describes addition-nucleophilic reactions of 1-(5-R 1 -2-furyl)-2-R 2 -R 3 -ethylenes with SH (thioglycolic acid), NH 2 (glycine) and OH (phenol) nucleophiles, and with hydroxyl ions in aqueous media. The determined rate constants, of second order (dm 3 mol -1 s -1 ), show that in the physiological conditions the preferential reaction will be that with thiols. The amino acid composition of proteins modified with 1-(5-nitro-2-furyl)-2-nitro-2-methoxycarbonylethylene has revealed that the only group affected was the SH group of cysteine. This finding points out the significance of addition-nucleophilic SH-interactions of 2-furylethylenes with the protein macromolecules and accounts for the high cytotoxicity of these compounds.
Influence of Threonine Metabolism on <i>S</i> -Adenosylmethionine and Histone Methylation (2012)

Threonine is the only amino acid critically required for the pluripotency of mouse embryonic stem cells (mESCs), but the detailed mechanism remains unclear. We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in pluripotent stem cells, resulting in regulation of histone methylation. Isotope labeling of mESCs revealed that threonine provides a substantial fraction of both the cellular glycine and the acetyl-coenzyme A (CoA) needed for SAM synthesis. Depletion of threonine from the culture medium or threonine dehydrogenase (Tdh) from mESCs decreased accumulation of SAM and decreased trimethylation of histone H3 lysine 4 (H3K4me3), leading to slowed growth and increased differentiation. Thus, abundance of SAM appears to influence H3K4me3, providing a possible mechanism by which modulation of a metabolic pathway might influence stem cell fate.
Hematopoietic stem cell mobilization with the reversible CXCR4 receptor inhibitor plerixafor (AMD3100)—Polish compassionate use experience (2010)

Recent developments in the field of targeted therapy have led to the discovery of a new drug, plerixafor, that is a specific inhibitor of the CXCR4 receptor. Plerixafor acts in concert with granulocyte colony-stimulating factor (G-CSF) to increase the number of stem cells circulating in the peripheral blood (PB). Therefore, it has been applied in the field of hematopoietic stem cell mobilization. We analyzed retrospectively data regarding stem cell mobilization with plerixafor in a cohort of 61 patients suffering from multiple myeloma (N = 23), non-Hodgkin’s lymphoma (N = 20), or Hodgkin’s lymphoma (N = 18). At least one previous mobilization attempt had failed in 83.6% of these patients, whereas 16.4% were predicted to be poor mobilizers. The median number of CD34+ cells in the PB after the first administration of plerixafor was 22/μL (range of 0–121). In total, 85.2% of the patients proceeded to cell collection, and a median of two (range of 0–4) aphereses were performed. A minimum of 2.0 × 106 CD34+ cells per kilogram of the patient’s body weight (cells/kg b.w.) was collected from 65.6% of patients, and the median number of cells collected was 2.67 × 106 CD34+ cells/kg b.w. (0–8.0). Of the patients, 55.7% had already undergone autologous stem cell transplantation, and the median time to neutrophil and platelet reconstitution was 12 and 14 days, respectively. Cases of late graft failure were not observed. We identified the diagnosis of non-Hodgkin’s lymphoma and previous radiotherapy as independent factors that contributed to failure of mobilization. The current report demonstrates the satisfactory efficacy of plerixafor plus G-CSF for stem cell mobilization in heavily pre-treated poor or predicted poor mobilizers.
ChemInform Abstract: Encapsulation of Guest Molecules into a Dendritic Box. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sensitive Detection of Nucleic Acids with Rolling Circle Amplification and Surface-Enhanced Raman Scattering Spectroscopy (2010)

Detection of specific DNA sequences is important to molecular biology research and clinical diagnostics. To improve the sensitivity of surface-enhanced Raman scattering spectroscopy (SERS), a variety of signal amplification methods has been developed, including Raman-active-dye, polymerase chain reaction (PCR) technology, molecular beacon, SERS-active substrates, and SERS-tag. However, the combination of rolling circle amplification (RCA) with SERS for nucleic acid detection has not been reported. Herein, we describe a new approach for nucleic acid detection by the combination of RCA reaction with SERS. Because of the binding of abundance repeated sequences of RCA products with gold nanoparticle (Au NP) and Rox-modified detection probes, SERS signal is significantly amplified and the detection limit of 10.0 pM might be achieved. The sensitivity of RCA-based SERS has increased by as much as 3 orders of magnitude as compared to PCR-based SERS and is also comparable with or even exceeds that of both RCA-based electrochemical and RCA-based fluorescent methods. This RCA-based SERS might discriminate perfect matched target DNA from 1-base mismatched DNA with high selectivity. The high sensitivity and selectivity of RCA-based SERS makes it a potential tool for early diagnosis of gene-related disease and also offers a great promise for multiplexed assays with DNA microarrays.
Expression of ErbB receptor proteins and TGF-alpha during diethylnitrosamine-induced hepatocarcinogenesis in the rat liver. (2007)

Increased expression of EGF-R and decreased expression of ErbB4, might be related with tumor progression during DEN-induced hepatocarcinogenesis.