gebhart/patrepeval huggingface dataset:
A survey of simulated annealing as a tool for single and multiobjective optimization (2005)

This paper presents a comprehensive review of simulated annealing (SA)-based optimization algorithms. SA-based algorithms solve single and multiobjective optimization problems, where a desired global minimum/maximum is hidden among many local minima/maxima. Three single objective optimization algorithms (SA, SA with tabu search and CSA) and five multiobjective optimization algorithms (SMOSA, UMOSA, PSA, WDMOSA and PDMOSA) based on SA have been presented. The algorithms are briefly discussed and are compared. The key step of SA is probability calculation, which involves building the annealing schedule. Annealing schedule is discussed briefly. Computational results and suggestions to improve the performance of SA-based multiobjective algorithms are presented. Finally, future research in the area of SA is suggested.
A 1550 NM phase change electro-optical shutter (2016)

This paper introduces a new electro-optical shutter with measured transmission loss of less than 1.3 dB in the shutter ON state and isolation of ~14 dB in the shutter OFF state. The shutter is composed of sub-wavelength metallic slits filled with germanium telluride (GeTe) phase change material (PCM). The slits serve both as waveguides for extra-ordinary transmission of optical signal and as nano-heaters for changing the phase of GeTe. This work focuses on thermal and optical characterization of the GeTe slits in both amorphous and crystalline states through Joule heating. As GeTe goes through its phase transition, its complex reflective index changes, resulting in a significant shift in the optical property of the shutter. In this work, the shutter is designed to have a strong peak in the transmission (with >75% transmission amplitude) at 1550 nm in the amorphous (OFF) state of GeTe. When GeTe crystalizes, the wavelength of transmission peak shifts and the transmission amplitude is modulated, resulting in only 4% transmission at 1550 nm. To the best of our knowledge, this work is the first demonstration of optical modulators using PCM and providing such a high contrast.
Mitochondrial metals as a potential therapeutic target in neurodegeneration (2013)

Transition metals are critical for enzyme function and protein folding, but in excess can mediate neurotoxic oxidative processes. As mitochondria are particularly vulnerable to oxidative damage due to radicals generated during ATP production, mitochondrial biometal homeostasis must therefore be tightly controlled to safely harness the redox potential of metal enzyme cofactors. Dysregulation of metal functions is evident in numerous neurological disorders including Alzheimer's disease, stroke, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedrich's ataxia. This review describes the mitochondrial metal defects in these disorders and highlights novel metal-based therapeutic approaches that target mitochondrial metal homeostasis in neurological disorders.
A Microprocessor-Controlled Chemical Detection and Alarm System Based on Ion Mobility Spectrometry (1985)

This paper describes a chemical alarm system based on ion mobility spectrometry. The system consists of an ion mobility cell, a microprocessor, and an operator interface. The unit is designed to alarm on specific chemical vapors based on a signal acquired from the ion mobility cell by the microprocessor. The microprocessor triggers the cell, collects the data, filters the data, and implements a decision process based on linear discriminant functions. The paper describes the overall system and looks at the filtering and decision processes in detail.
Characterization of the mannose/fucose receptor on human mononuclear phagocytes. (1982)

Cells of the mononuclear phagocyte system contain a cell surface receptor which mediates the uptake of mannose- and fucose-terminated glycoproteins. We have extended the initial studies to human alveolar and monocyte-derived macrophages in culture using two radiolabelled ligands, the synthetic glycoconjugate mannose-bovine serum albumin and the lysosomal glycosidase, beta-glucuronidase. Uptake (37 degrees C) of 125I-mannose-BSA by freshly isolated alveolar macrophages is saturable with increasing concentrations of ligand. Kuptake values in macrophages of smokers and nonsmokers are similar, and resemble earlier reported values using rabbit alveolar macrophages (Kuptake = 40 nM). Uptake of 125I-mannose-BSA in cultured smoker macrophages is identical to that found in fresh cells, and uptake is stable for 5-10 days in culture. Fucose- and mannose-BSA are the most effective inhibitors of uptake, while N-acetylglucosamine-BSA is inhibitory at slightly higher concentrations. Binding (4 degrees C) of 125I-mannose-BSA is likewise ligand concentration dependent (KD = 30 nM). Freshly isolated human monocytes from healthy subjects and patients with cystic fibrosis do not have mannose-specific uptake. However, after monocytes are in culture for 3 days, mannose-specific uptake appears and Kuptake values and specificity of uptake are identical with the results from the alveolar macrophages. No uptake of mannose-BSA could be found in the human monocyte-like cell line, U937.
New Method for Measuring the Absolute Viscosity of Liquid Helium II (1956)

A new type of static viscometer for use in liquid helium II has been developed in which the inner cylinder is suspended within a rigidly fixed, coaxial, outer cylinder by a servomechanically controlled magnetic bearing of the type used by Beams and others in vacuum ultracentrifuges. The inner cylinder is accelerated electromagnetically and the absolute viscosity of the medium is determined from the deceleration observed when it is permitted to coast freely. Bearing friction is negligible, and there is no inherent lower limit to the speed of the rotor. Reproducible viscosity values were obtained in gaseous helium. In liquid helium II damping proportional to $\frac{1}{\mathrm{TS}}$ caused by thermomechanical flow, induced by eddy-current heating, was observed. This effect was reduced considerably by elaborate precautions to isolate the apparatus from ground vibrations; further improvement would require more favorable location of the apparatus. At higher speeds, the anomalous behavior reported elsewhere was again observed. The absolute viscosity was found to increase discontinuously to a higher value as the speed was increased. The observation is reproducible qualitatively, but, because of vibrations, not quantitatively. Attention is called to a possible analogy between this phenomenon and the observation of stable vorticity in water.
Phase I clinical comparative study of monoclonal antibody KS1/4 and KS1/4-methotrexate immunconjugate in patients with non-small cell lung carcinoma. (1990)

A Phase Ia clinical trial was undertaken to evaluate and compare murine monoclonal antibody KS1/4 and KS1/4-methotrexate immunoconjugate in patients with Stage IIIB or IV non-small cell carcinoma of the lung. Six patients received KS1/4 alone and five patients received KS1/4-methotrexate conjugate. The maximal total dose received per patient in both groups was 1661 mg. Mild to moderate side effects in both groups included fever, chills, anorexia, nausea, vomiting, diarrhea, anemia, and brief transaminasemia. One patient who received antibody alone had an apparent acute immune complex-mediated reaction. Ten of 11 patients had a human anti-mouse response. Posttreatment carcinoma biopsies revealed binding of monoclonal antibody KS1/4 and deposition of C3d and C4c complement fragments. Monoclonal antibody binding and complement deposition correlated with increasing doses of infused antibody. There was one possible clinical response.
Thermoelectric characteristics of the spark plasma-sintered silicon boride ceramics (2005)

Silicon boride () is very promising for use as thermoelectric materials at high temperature because of its high melting point and relatively large Seebeck coefficient. In the present work, spark plasma sintering (SPS) was applied for preparing dense ceramics, and their thermoelectric properties were investigated, together with their microstructural evaluation. The SPS process was found to be effective in densifying a ceramic, typically 99 % of the theoretical density at low temperature of . In comparison with specimen prepared by hot-pressing, the SPS-processed specimen exhibited the significantly improved Seebeck coefficient, resulting in the higher power factor.
Effects of dietary changes and yeast culture (Saccharomyces cerevisiae) on rumen microbial fermentation of Holstein heifers1 (2009)

The effects of a dietary challenge to induce digestive upsets and supplementation with yeast culture on rumen microbial fermentation were studied using 12 Holstein heifers (277 +/- 28 kg of BW) fitted with a ruminal cannula, in a crossover design with 2 periods of 5 wk. In each period, after 3 wk of adaptation to a 100% forage diet, the dietary challenge consisted of increasing the amount of grain at a rate of 2.5 kg/d (as-fed basis) over a period of 4 d, until a 10:90 forage:concentrate diet was reached, and then it was maintained for 10 d. Between periods, animals were fed again the 100% forage diet without any treatment for 1 wk as a wash-out period. Treatments started the first day of each period, and they were a control diet (CL) or the same diet with addition of yeast culture (YC, Diamond V XPCLS). Digestive upsets were determined by visual observation of bloat or by a reduction in feed intake (as-fed basis) of 50% or more compared with intake on the previous day. Feed intake was determined daily at 24-h intervals during the adaptation period and daily at 2, 6, and 12 h postfeeding during the dietary challenge. Ruminal liquid samples were collected daily during the dietary challenge to determine ruminal pH at 0, 3, 6, and 12 h postfeeding, and total and individual VFA, lactic acid, ammonia-N, and rumen fluid viscosity at 0 and 6 h postfeeding. The 16s rRNA gene copies of Streptococcus bovis and Megasphaera elsdenii were determined by quantitative PCR. Foam height and strength of the rumen fluid were also determined the day after the digestive upset to evaluate potential foam production. A total of 20 cases (83.3%) of digestive upsets were recorded in both periods during the dietary challenge, all diagnosed due to a reduction in feed intake. Rumen fermentation profile at 0 h on the digestive upset day was characterized by low ruminal pH, which remained under 6.0 for 18 h, accompanied by elevated total VFA concentration and, in some cases, by elevated lactate concentration. Addition of YC during the dietary challenge did not affect the incidence (10 cases per treatment) or time (7.00 +/- 0.62 d) to digestive upset. However, YC reduced (P < 0.05) the foam strength on the day after digestive upset, suggesting potential benefits of reducing the risk of developing bloat. The proposed dietary challenge model was successful in causing a digestive upset as indicated by reduced feed intake, but the YC addition had no significant impact on rumen fermentation.
Epipolar Resampling of Space-borne Linear Array Scanner Scenes Using Parallel Projection (2006)

Epipolar resampling aims at generating normalized images where conjugate points are located along the same row. Such a characteristic makes normalized imagery important for many applications such as automatic image matching, aerial triangulation, DEM and ortho-photo generation, and stereo-viewing. Traditionally, the input media for the normalization process are digital images captured by frame cameras. These images could be either derived by scanning analog photographs or directly captured by digital cameras. Current digital frame cameras provide smaller format imagery compared to those of analog cameras. In this regard, linear array scanners are emerging as a viable substitute to two-dimensional digital frame cameras. However, linear array scanners have more complex imaging geometry than that of frame cameras. In general, the imaging geometry of linear array scanners produces non-straight epipolar lines. Moreover, epipolar resampling of captured scenes according to the rigorous model, which faithfully describes the imaging process, requires the knowledge of the internal and external sensor characteristics as well as a Digital Elevation Model (DEM) of the object space. Recently, parallel projection has emerged as an alternative model approximating the imaging geometry of high altitude scanners with narrow angular field of view. In contrast to the rigorous model, the parallel projection model does not require the internal or the external characteristics of the imaging system and produces straight epipolar lines. In this paper, the parallel projection equations are modified for better modeling of linear array scanners. The modified parallel projection model is then used to resample linear array scanner scenes according to epipolar geometry. Experimental results using Ikonos and SPOT data demonstrate the feasibility of the proposed methodology.
HIGH STRENGTH STEELS FOR AUTOMOTIVE SAFETY PARTS (2001)

<div class="htmlview paragraph">Energy savings are among the most important goals of steel users. Usinor proposes a wide range of very high strength steels (HSLA, DP, TRIP, etc.) for weight reduction and impact resistance. This text deals with the mechanical testing and different design solutions associated with these steel grades. Tensile and formability properties are presented first by means of basic tests (drawing, stretching, bending, etc.) in order to classify the different steels. A specific part of the text deals with a ultra high tensile strength pre-coated boron steel for hot forming. In addition to this, the crash resistance is investigated by using a dynamic axial compression test and a dynamic three point bending test on structural components with closed and open cross sections. For each steel grade, the estimated weight saving potential is compared with respect to parts manufactured in high drawability steel. Finally, two different designs are presented with steel solutions for safety parts. The first one shows the advantage of the use of TRIP steel and a hydroforming technique for a crash box instead of using a conventional forming technique. The second one deals with the design of a cross frontal sill with a complex cross section, formed using a profile rolling technique.</div>
ModelarDB (2018)

Industrial systems, e.g., wind turbines, generate big amounts of data from reliable sensors with high velocity. As it is unfeasible to store and query such big amounts of data, only simple aggregates are currently stored. However, aggregates remove fluctuations and outliers that can reveal underlying problems and limit the knowledge to be gained from historical data. As a remedy, we present the distributed Time Series Management System (TSMS) ModelarDB that uses models to store sensor data. We thus propose an online, adaptive multi-model compression algorithm that maintains data values within a user-defined error bound (possibly zero). We also propose (i) a database schema to store time series as models, (ii) methods to push-down predicates to a key-value store utilizing this schema, (iii) optimized methods to execute aggregate queries on models, (iv) a method to optimize execution of projections through static code-generation, and (v) dynamic extensibility that allows new models to be used without recompiling the TSMS. Further, we present a general modular distributed TSMS architecture and its implementation, ModelarDB, as a portable library, using Apache Spark for query processing and Apache Cassandra for storage. An experimental evaluation shows that, unlike current systems, ModelarDB hits a sweet spot and offers fast ingestion, good compression, and fast, scalable online aggregate query processing at the same time. This is achieved by dynamically adapting to data sets using multiple models. The system degrades gracefully as more outliers occur and the actual errors are much lower than the bounds.
Reactant Concentrations from Fluorescence Correlation Spectroscopy with Tailored Fluorescent Probes. An Example of Local Calibration-Free pH Measurement (2005)

The present account is concerned with the measurement of local reactant concentrations by observing specific fluorescent probes in fluorescence correlation spectroscopy (FCS). The Theoretical Analysis section revisits the photophysical, thermodynamic, and kinetic information that is contained in the corresponding FCS correlation curves. In particular, we examine the conditions under which FCS is revealed as a superior tool to measure concentrations of reactive species. Careful molecular engineering of the specific fluorescent probes that simultaneously integrates photophysical, thermodynamic, and kinetic constraints will be required to benefit most from FCS. We illustrate the FCS titration approach with a series of fluorescent probes that we tailored to measure pH at around 4-6 by FCS after two-photon excitation. We show that an optimal design allows one to access pH without any preliminary calibrations such as the determination of the protonation constant or the photophysical properties of the fluorescent probe.
Immunohistochemical Detection of Leukemia Inhibitory Factor After Focal Cerebral Ischemia in Rats (2000)

The cytokine leukemia inhibitory factor (LIF) modulates neuronal function during development and promotes neuronal survival after peripheral nerve injury, but little is known about LIF expression after cerebral ischemia. In the present study, the localization of LIF protein was immunohistochemically examined in rats after 3.5, 12, 24, 48, and 96 hours of reperfusion following 1.5 hours of middle cerebral artery occlusion (MCAO) induced by the intraluminal suture method. Double-staining immunohistochemistry with microtubule-associated protein-2 (MAP2), glial fibrillary acidic protein (GFAP), lectin histochemistry, and interleukin (IL) 6 was also performed. The sham group and immunosorption test did not show any clear LIF immunoreactivity. Definite LIF immunoreactivity was first detected after 12 hours of reperfusion in each of the brain regions examined: ischemic core, periinfarct region, and contralateral cortex. However, expression of LIF was most prominent in the periinfarct region at each time point, peaked at 24 hours, and then gradually declined until 96 hours of reperfusion. Some LIF-positive neurons in the periinfarct region expressed IL-6. At 96 hours of reperfusion, GFAP-labeled astrocytes around the infarct core also expressed LIF protein. Induction of LIF mRNA and protein was also confirmed by reverse transcription polymerase chain reaction and western blot analysis, respectively. These findings suggest that LIF expression in ischemically threatened neurons may reflect a repair or defense mechanism against the ischemic insult.
Background-free intensity autocorrelator employing Si avalanche photodiode as two-photon absorber (2002)

A background-free intensity autocorrelator has been developed using two-photon absorption (TPA) in a Si avalanche photodiode (APD). Light passing through two arms of the Mach-Zehnder interferometer is chopped at different frequencies, f1 and f2, and the background level in the TPA signal is eliminated by measuring the output of the Si APD at the difference frequency of | f1−f2| using a lock-in amplifier. This background-free autocorrelator has a dynamic range of 30 dB together with high sensitivity, enabling the waveform of optical pulses at 1550 nm to be determined precisely.
Topological design of loss-free switch-based LANs (2002)

The paper presents a new design methodology and tools to construct a switch-based LAN with (i) scalable throughput, (ii) no loss due to congestion, and (iii) two routing modes: FIFO or non-FIFO. More specifically, given a bounded degree (number of switch ports) at each node, the design is based on the construction of multiple virtual rings under the following constraints: (i) the virtual rings are pairwise edge-disjoint, and (ii) there is at least one virtual ring between any pair of nodes. The target topology is obtained from the edge union of the multiple virtual rings. The objectives of the above two constraints are (i) to ensure no loss due to congestion inside the network of bursty traffic sources, and (ii) to ensure convergence of packets/cells to their destinations. The virtual rings are constructed by a new methodology that employs combinatorial block designs together with a new algorithm for realizing any size networks. It is shown that the bound on the maximum route length, under the two constraints, is O(/spl radic/N) for an N-node network.
Externally disposed plasma membrane proteins. I. Enzymatic iodination of mouse L cells. (1975)

The enzymatic iodination technique has been utilized in a study of the externally disposed membrane proteins of the mouse L cell. Iodination of cells in suspension results in lactoperoxidase-specific iodide incorporation with no loss of cell viability under the conditions employed, less than 3% lipid labeling, and more than 90% of the labeled species identifiable as monoiodotyrosine. 90% of the incorporated label is localized to the cell surface by electron microscope autoradiography, with 5-10% in the centrosphere region and postulated to represent pinocytic vesicles. Sodium dodecylsulfate-polyacrylamide gels of solubilized L-cell proteins reveals five to six labeled peaks ranging from 50,000 to 200,000 daltons. Increased resolution by use of gradient slab gels reveals 15-20 radioactive bands. Over 60% of the label resides in approximately nine polypeptides of 80,000 to 150,000 daltons. Various controls indicate that the labeling pattern reflects endogenous membrane proteins, not serum components. The incorporated 125-I, cholesterol, and one plasma membrane enzyme marker, alkaline phosphodiesterase I, are purified in parallel when plasma membranes are isolated from intact, iodinated L cells. The labeled components present in a plasma membrane-rich fraction from iodinated cells are identical to those of the total cell, with a 10- to 20-fold enrichment in specific activity of each radioactive peak in the membrane.
Podium: Ranking Data Using Mixed-Initiative Visual Analytics (2017)

People often rank and order data points as a vital part of making decisions. Multi-attribute ranking systems are a common tool used to make these data-driven decisions. Such systems often take the form of a table-based visualization in which users assign weights to the attributes representing the quantifiable importance of each attribute to a decision, which the system then uses to compute a ranking of the data. However, these systems assume that users are able to quantify their conceptual understanding of how important particular attributes are to a decision. This is not always easy or even possible for users to do. Rather, people often have a more holistic understanding of the data. They form opinions that data point A is better than data point B but do not necessarily know which attributes are important. To address these challenges, we present a visual analytic application to help people rank multi-variate data points. We developed a prototype system, Podium, that allows users to drag rows in the table to rank order data points based on their perception of the relative value of the data. Podium then infers a weighting model using Ranking SVM that satisfies the user's data preferences as closely as possible. Whereas past systems help users understand the relationships between data points based on changes to attribute weights, our approach helps users to understand the attributes that might inform their understanding of the data. We present two usage scenarios to describe some of the potential uses of our proposed technique: (1) understanding which attributes contribute to a user's subjective preferences for data, and (2) deconstructing attributes of importance for existing rankings. Our proposed approach makes powerful machine learning techniques more usable to those who may not have expertise in these areas.