gebhart/patrepeval huggingface dataset:
Dispersion-free amplification of femtosecond dye-laser pulses (1992)

Amplification of femtosecond pulses through spatial expansion and recompression in a temporally nondispersive grating apparatus is demonstrated. The system used does not lengthen the pulse, provides higher gain than conventional amplifiers, and separates effectively the amplified spontaneous emission from the signal. The output pulse duration is easily controlled from tau(min) = 50 fs to several hundred femtoseconds by fine adjustment of the components used in the spatially dispersive scheme.
Aggregation of Platelets and Inert Particles Induced by Thrombin (1976)

Summary Thrombin-induced platelet aggregation and release were investigated in washed platelet suspensions and in suspensions of inert particles in order to evaluate the role of fibrinogen-fi-brin transformation in aggregometer tracings. Thrombin (0.25–2.0 U/ml) produced two waves of light transmission increase (LTI) in both platelet and inert particle suspensions containing fibrinogen, and concomittantly aggregates were observed under phase microscopy. Without fibrinogen, thrombin induced rapid release of platelet ADP but failed to cause second wave of LTI. The kinetics of LTI in platelet and inert particle systems were related to both thrombin and fibrinogen concentrations. A rapid second wave of LTI could be produced by direct interaction of thrombin-treated platelets or inert particles with polymerizing fibrin, and was inhibited by sodium sulfite and low pH of 5.1 which prevent fibrin monomer polymerization. No fibrin strands were noted in platelet aggregates fixed at the completion of the second wave of LTI. Apyrase and PGE1 inhibited the rate of first but not that of second wave LTI. The results suggest that the release of platelet ADP induced by thrombin primarily affects the first phase aggregation, and the second phase may result from interaction of thrombin-exposed platelets and polymerizing fibrin. Thus, the blood coagulation mechanism may be directly involved in platelet aggregation.
What Moves the Invisible Hand: The Unaddressed Linkages Between the Psychological Study of Religion and Managerial Behaviour (1992)

Years ago, Henry D. Lloyd defined religion as being the “conscience in action.” The concept of religion is one which is indeed completely individualised in both perspective and importance. However, as Bailey (1983) observed, the very basis for theology lies in the explanatory power of religion when examined through the perspective of psychology. Byron (1988) saw a theological basis to the functions of management and entrepreneurship, linking these activities to the religious duty of stewardship.
Myocardial β-Adrenergic Receptor Density Assessed by <sup>11</sup>C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy (2009)

Myocardial beta-AR density is more tightly related to improvement of LVEF-carvedilol than is cardiac contractile reserve in patients with IDC. Patients with decreased myocardial beta-AR have higher resting adrenergic drive, as reflected by plasma norepinephrine, and may receive greater benefit from being treated by antiadrenergic drugs.
Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation (2016)

The C-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit contains tandem repeats of the heptapeptide, Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. The CTD is subject to dynamic phosphorylation during transcription, mainly at serine residues (Ser2, Ser5 and Ser7). Regulation of CTD phosphorylation by specific kinases and phosphatases is crucial for coordinating transcription with RNA processing and histone modification. Human small CTD phosphatase 4 (SCP4), also called CTDSPL2 or HSPC129, is a putative CTD phosphatase belonging to the FCP/SCP family and implicated in control of ε- and γ-globin gene expression. Here, we report the biochemical and functional characterization of SCP4. SCP4 exhibited Ser5-preferential CTD phosphatase activity in vitro, while small interfering RNA-mediated SCP4 knockdown in HeLa cells increased phosphorylation levels of Pol II at Ser5 and Ser7, but not at Ser2. Furthermore, cell fractionation, chromatin immunoprecipitation and immunofluorescence assays revealed an exclusive localization for SCP4 in the chromatin, particularly at transcriptionally silenced chromosomal regions. Interestingly, SCP4 was gradually released from the chromatin fraction during hemin-induced erythroid differentiation of K562 cells, with concomitant cytoplasmic accumulation. Therefore, SCP4 is a unique chromatin-associated, Ser5-preferential CTD phosphatase that preferentially distributes to transcriptionally silenced gene regions and may participate in gene regulation during erythroid differentiation.
Encoding Monadic Computations in C# Using Iterators. (2009)

Abstract. Many programming problems can be easily solved if we express them as computations with some non-standard aspect. This is a very important problem, because today we’re struggling for example to efficiently program multi-core pro-cessors and to write asynchronous code. Unfortunately main-stream languages such as C # don’t support any direct way for encoding unrestricted non-standard computations. In languages like Haskell and F#, this can be done using monads with syntactic extensions they provide and it has been successfully applied to a wide range of real-world prob-lems. In this paper, we present a general way for encoding monadic computations in the C # 2.0 language with a conve-nient syntax using a specific language feature called itera-tors. This gives us a way to use well-known non-standard computations enabling easy asynchronous programming or for example the use of software transactional memory in plain C#. Moreover, it also opens monads in general to a wider audience which can help in the search for other useful and previously unknown kinds of computations. 1.
The Relation of the Economic Entomologist to Agriculture (1908)

Journal Article The Relation of the Economic Entomologist to Agriculture Get access H. A. Morgan H. A. Morgan Knoxville, Tenn. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 1, Issue 1, 1 February 1908, Pages 11–15, https://doi.org/10.1093/jee/1.1.11 Published: 01 February 1908
European recommendations on the use of oral antibiotics for acne. (2005)

Non-rational prescribing of oral antibiotics in acne is common, and there is currently an unmet need for up-to-date guidelines that specifically address these issues. Presented here is a set of recommendations on the use of oral antibiotics in acne, developed by a group of European acne specialists, designed to be considered by dermatologists and general practitioners in their daily practice throughout Europe. Recommendations cover optimal choice of antibiotic, drug doses, duration of treatment, combination treatment, and maintenance therapy.
Cysteine‐Containing Polyisocyanides as Versatile Nanoplatforms for Chromophoric and Bioscaffolding (2010)

The straightforward syntheses of polyisocyanides containing the alanine-cysteine motif in their side chains have been achieved. Detailed characterization of the polymers revealed a well-defined and highly stable helical conformation of the polyimine backbone responsible for the formation of rodlike structures of over one hundred nanometers. The 4(1) helix is further stabilized by beta-sheet-like interactions between the peptide arms. As a result, the cysteine sulfur atoms are regularly aligned along the polymer axis, which provides a unique platform for the scaffolding of various entities by using versatile click-chemistry postmodification approaches. For instance, pyrene derivatives were introduced through thio-specific reactions involving either maleimide, iodoacetamide, or thioester groups, leading to arrays of stacked chromophores with excimer-like emission. A water-soluble cysteine-rich polyisocyanide was successfully biotinylated and coupled to streptavidin.
Development in video technology for coaching (2008)

The first section of this article contains a brief description of the video technology that is commonly used in coaching. Camcorders and digital video linked to computer capture and control provide inexpensive training tools for coaches. The rationale for the use of video in coaching is then presented from the perspective of a sports biomechanist. The objective is to enhance coach and athlete performance through a better understanding of all aspects of the athlete's performance. The use of video permits the coach to first focus on the coaching task with video providing additional tools for performance review. How we use the technology with examples of the application of video technology in sports is discussed in the next section of the article. For coaching, the emphasis is on qualitative uses of video for game analysis of technical skills, assessment and monitoring of technical skills, feedback in training, and reporting and presentation. Finally, areas of development are presented that will enhance the use of video in coaching (i.e. smart systems for movement analysis), real‐time skill analysis and ‘soft’ real‐time auto‐coding of performance.
Transformed pseudo-random patterns for BIST (2002)

This paper presents a new approach for on-chip test pattern generation. The set of test patterns generated by a pseudo-random pattern generator (e.g., an LFSR) is transformed into a new set of patterns that provides the desired fault coverage. The transformation is performed by a small amount of mapping logic that decodes sets of patterns that don't detect any new faults and maps them into patterns that detect the hard-to-detect faults. The mapping logic is purely combinational and is placed between the pseudo-random pattern generator and the circuit under test (CUT). A procedure for designing the mapping logic so that it satisfies test length and fault coverage requirements is described. Results are shown for benchmark circuits which indicate that an LFSR plus a small amount of mapping logic reduces the test length required for a particular fault coverage by orders of magnitude compared with using an LFSR alone. These results are compared with previously published results for other methods, and it is shown that the proposed method requires much less overhead to achieve the same fault coverage for the same test length.
Mixed‐Linkage Glucan Oligosaccharides Produced by Automated Glycan Assembly Serve as Tools To Determine the Substrate Specificity of Lichenase (2017)

The mixed-linkage (1→3),(1→4)-d-glucan (MLG) specific glycosyl hydrolase lichenase is an important biochemical tool for the structural characterization of MLGs. It holds potential for application in the brewery, animal feed, and biofuel industries. Several defined MLG oligosaccharides obtained by automated glycan assembly are used to analyze the substrate specificities of Bacillus subtilis lichenase. Two glucose building blocks (BBs), equipped with a temporary fluorenylmethyloxycarbonyl chloride (Fmoc) protecting group in the C-3 or C-4 position, served to assemble different oligosaccharides by using an automated oligosaccharide synthesizer. Light-induced cleavage of the glycan products from the solid support followed by global deprotection provided seven MLG oligosaccharides of different length and connectivity. After incubation of the MLG oligosaccharides with lichenase, the digestion products were analyzed by HPLC-MS. These digestion experiments provided insights into the enzyme's active site that is in line with other recent evidence suggesting that the substrate specificity of lichenases has to be reconsidered. These results demonstrate that synthetic MLG oligosaccharides are useful tools to analyze mixed-linkage β-glucanases.
Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells (2009)

We showed ginseng suppressed part of the TNF-alpha-inducible cytokines and signalling proteins in promonocytic cells, suggesting that it exerts its anti-inflammatory property targeting at different levels of TNF-alpha activity. The anti-inflammatory role of ginseng may be due to the combined effects of ginsenosides, contributing in part to the diverse actions of ginseng in humans.
Decomposition of the Wigner-Ville distribution and time-frequency distribution series (1994)

Using the orthogonal-like Gabor expansion, the authors decompose the Wigner-Ville distribution (WVD) to a linear combination of localized and symmetric functions WVD/sub h, h'/ (t, w), the WVD of the Gabor elementary functions, h/sub m, n/(t) and h/sub m'n'/(t). Since the influence of the WVD/sub h, h'/(t, w) to the useful properties is inversely proportional to the distance between h/sub m, n/ (t) and h/sub m', n't/, the WVD/sub h, h'/(t, w) are further grouped as a series of the function P/sub d/(t, w). The authors name the resulting representation the time-frequency distribution series (TPDS) (also known as the Gabor spectrogram in industry). The TFDSD consists of up to a Dth order P/sub d/(t, w). While TFDS/sub 0/(t, w)=P/sub 0/(t, w) is similar to the spectrogram, TFDS/sub /spl infin//(t, w) converges to the WVD/sub s/(t, w). Numerical simulations demonstrate that adjusting the order D of the TFDS, one could effectively balance the cross-term interference and the useful properties.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DNA Contacts Stimulate Catalysis by a Poxvirus Topoisomerase (1999)

Eukaryotic type 1B topoisomerases act by forming covalent enzyme-DNA intermediates that transiently nick DNA and thereby release DNA supercoils. Here we present a study of the topoisomerase encoded by the pathogenic poxvirus molluscum contagiosum. Our studies of DNA sites favored for catalysis reveal a larger recognition site than the 5'-(T/C)CCTT-3' sequence previously identified for poxvirus topoisomerases. Separate assays of initial DNA binding and covalent complex formation revealed that different DNA sequences were important for each reaction step. The location of the protein-DNA contacts was mapped by analyzing mutant sites and inosine-substituted DNAs. Some of the bases flanking the 5'-(T/C)CCTT-3' sequence were selectively important for covalent complex formation but not initial DNA binding. Interactions important for catalysis were probed with 5'-bridging phosphorothiolates at the site of strand cleavage, which permitted covalent complex formation but prevented subsequent religation. Kinetic studies revealed that the flanking sequences that promoted recovery of covalent complexes increased initial cleavage instead of inhibiting resealing of the nicked intermediate. These data 1) indicate that previously unidentified DNA contacts can accelerate a step between initial binding and covalent complex formation and 2) help specify models for conformational changes promoting catalysis.
Low-temperature growth of single-wall carbon nanotubes (2007)

The low-temperature synthesis (450–560 °C) of single-walled carbon nanotubes (SWCNTs) on a triple-layered catalyst, Al/Fe/Mo, was performed using aromatic hydrocarbon radicals which were produced from the pyrolysis of C2H2. Two approaches were used; in the first, these hydrocarbon radicals were produced using a high-temperature heater (830 °C), but the substrate where the SWCNTs were grown was placed on a thermal insulator above it such that the substrate was at a much lower temperature. In the second approach, a heated nozzle system operating at 830 °C was used to introduce the hydrocarbon radicals onto the substrate which was located a few centimetres below it. Both these approaches rely on the thermal dissociation and recombination of C2H2 for the formation of complex high-order radicals, i.e. C6H9, C5H9, C6H13, whose presence was confirmed by in situ mass spectroscopy. The density of SWCNTs deposited could be correlated directly with the concentration of these precursors.
Patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum (2011)

Recent findings about the pathogenesis of pustulosis palmaris et plantaris (PPP), also known as palmoplantar pustulosis, suggest that IL-17 expression in the acrosyringium as well as infiltration of IL-17 positive cells, e.g. Langerhans cells may play important roles. However, to date, it has not been established whether circulating IL-17 related cytokines are involved in PPP. We studied the circulating IL-17 related cytokines as well as the mRNA levels in lesional skin. IL-17 related cytokine mRNAs were increased in the PPP lesions compared with the control tissues (five patients vs five controls). The serum levels of TNF-alpha, IL-17, IL-22 and IFN-gamma also were significantly increased in PPP, but not IL-23 and IL-8 (48 patients vs 20 controls). Our findings document that not only the serum IL-17 but also tissue IL-17 are elevated in PPP and may be in the pathogenesis of this disorder.
Design and implementation of a bridge between CORBA's notification service and the Java message service (2003)

Messaging plays a central role in the development of distributed object-oriented systems. It is supported by the specification of the Java Message Service (JMS) and CORBA's Notification Service (CNS). In this paper we introduce the design and implementation of a bridge that enables message passing between applications based on JMS and CNS, respectively. We describe or design goals, elaborate on the problems that had to be solved, and cover various details of our implementation. The flexibility and extensive means to configure the bridge enable users to employ it in a large variety of applications.
Synthesen bicyclisch‐heterocyclischer Ringsysteme, 3. Mitt. 1‐(Halogenphenyl)substituierte 4,6‐Diaminopyrazolo[3,4‐d]pyrimidine (1979)

Abstract Die zu den 1‐(halogenphenyl)substituierten 4,6‐Diaminopyrazolo[3,4‐d]pyrimidinen 6a‐f führende Umsetzung der entsprechend substituierten 5‐Amino‐4‐cyanpyrazole 4a‐f mit Guanidin ( 5 ) läßt sich durch Erhitzen in Ethanol realisieren. Die hier erstmals beschriebenen 5‐Amino‐1‐(bromphenyl)‐4‐cyanpyrazole 4a und b gehen aus der Umsetzung von Ethoxymethylenmalononitril ( 1 ) mit den korrespondierenden Hydrazinderivaten 2a und b hervor.
Antecedents and consequents of service consumption experience in electronic mediated environment: empirical evidence from electronic service industry in China (2011)

This study examines how service consumption experience affects long-term relational exchange in the EME. An analytical framework is developed and tested to validate a comprehensive research model of service consumption experience and its antecedents and consequents, in the EME, leading to long-term exchange relationship between the consumers and service providers. Analyses of data from 415 Chinese consumers, with at least six months or more experience in consuming services in the EME, reveal that five service consumption experience dimensions significantly influence consumers' overall consumption experience in the EME. Service consumption experience is also found to serve as an important mediating variable between its antecedents and consequents. This study, as one of the first, contributes to the Information Systems literature through the development of the service consumption experience construct in the EME. Suggestions for future research and implications are discussed.
A multilevel hierarchical distributed IP mobility management scheme for wide area networks (2003)

Hierarchical Mobile IPv6 (HMIPv6) has been proposed as one solution to accommodate the frequent movements of mobile terminals (MTs) in IP-based mobile communication networks. HMIPv6 utilizes a mobility anchor point (MAP) that allows the network to manage the mobility of MTs without causing any overflow of outgoing and incoming messages beyond the network perimeter. However, there is a problem in applying HMIPv6 to a wide area network having a multilevel hierarchy. The distribution of several MAPs within such a network can be used as a means of optimizing the different mobility scenarios experienced by MTs. However, HMIPv6 allows MTs to select their own MAP, so with HMIPv6, the MTs may not select the MAP that would be chosen in an optimized scheme. This may cause load concentration at a particular MAP and/or overflow of signaling messages to and from outside networks. An effective IP mobility management method is proposed that focuses on the speed of movement of the MTs. It reduces the number of signaling messages to and from outside networks without suffering from load concentration at particular MAPs, and we show, by simulation experiments, that the proposed method works effectively.
Purification and some properties of alpha-L-arabinofuranosidase from Bacillus subtilis 3-6 (1994)

alpha-L-Arabinofuranosidase (EC 3.2.1.55) was purified from culture supernatant of Bacillus subtilis 3-6. The enzyme had a molecular weight of 61,000 and displayed maximum activity at pH 7.0 and 60 degrees C. It released arabinose from O-alpha-L-arabinofuranosyl-(1-->3)-O-beta-D-xylopyranosyl-(1-->4)-D-x ylopyranos e (A1X2), O-beta-D-xylopyranosyl-(1-->4)-[O-alpha-L-arabinofuranosyl-(1-->3)]- O-beta-D-xylopyranosyl-(1-->4)-D-xylopyranose (A1X3), and arabinan, but not from O-beta-D-xylopyranosyl-(1-->2)-O-alpha-L- arabinofuranosyl-(1-->3)-O-beta-D-xylopyranosyl-(1-->4)-O-beta-D-xylopyr anosyl- (1-->4)-D-xylopyranose (A1X4), arabinoxylan, gum arabic, or arabinogalactan.
New Oncolytic Adenoviruses with Hypoxia- and Estrogen Receptor-Regulated Replication (2002)

Oncolytic adenoviruses with restricted replication can be produced if the expression of crucial transcription units of the virus is controlled by tissue- or tumor-specific promoters. Here we describe a method for the rapid incorporation of exogenous promoters into the E1A and E4 regions of the human adenovirus type 5 genome. Using this system, we have generated AdEHT2 and AdEHE2F, two conditionally replicative adenoviruses for the treatment of breast cancer. The expression of the E1A gene in both viruses is controlled by a minimal dual-specificity promoter that responds to estrogens and hypoxia. The tight regulation of E1A expression correlated with the ability of these viruses to replicate and kill human cancer cells that express estrogen receptors, or are maintained under hypoxic conditions. The telomerase reverse transcriptase (TERT) promoter and the E2F-1 promoter are preferentially activated in cancer cells. They were introduced into the E4 region of AdEHT2 and AdEHE2F, respectively. The telomerase core promoter failed to block the replication of the virus in telomerase-negative cells. In contrast, AdEHE2F was attenuated in nontransformed quiescent cells growing under normoxic conditions, suggesting that an intact pRB pathway with low levels of E2F transcription factors acts as a negative modulator for the virus. These data indicate that the simultaneous regulation of E1A and E4 viral transcription units by the appropriate combination of promoters can increase the tumor selectivity of oncolytic adenoviruses.