gebhart/patrepeval huggingface dataset:
A new procoagulant in acute leukemia (1988)

To verify whether cancer procoagulant (CP), a cysteine proteinase procoagulant distinct from tissue factor (TF), is associated with leukemic cells, we assayed the procoagulant activity of blast cell extracts from 26 patients with different cytological subtypes of acute nonlymphoid leukemia (ANLL) according to the French-American-British classification. All the samples except two shortened the recalcification time of normal human plasma, the effect being significantly greater in the M3 subgroup. The two criteria used to distinguish between CP and TF, independence from factor VII in initiating blood coagulation and sensitivity to cysteine-proteinase inhibitors, were positive in 19 samples from M1, M2, M3, and M4 cytological subtypes. None of the M5 samples fulfilled these criteria. In addition, M1, M2, M3, and M4 samples immunoreacted with an anti-CP goat polyclonal antibody on an Ouchterlony immunodiffusion plate. This study provides the first evidence for a procoagulant other than TF that is associated with leukemic cells.
TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells (2010)

Reactive oxygen species (ROS) are generated as a result of normal cellular metabolism, mainly through the mitochondria and peroxisomes, but their release is enhanced by the activation of oxidant enzymes such as NADPH oxidases or downregulation of endogenous antioxidant enzymes such as manganese-superoxide dismutase (MnSOD) and catalase. Transforming growth factor-β (TGF-β), found to be overexpressed in airway smooth muscle (ASM) from asthmatic and chronic obstructive pulmonary disease patients, may be a pivotal regulator of abnormal ASM cell (ASMC) function in these diseases. An important effect of TGF-β on ASMC inflammatory responses is the induction of IL-6 release. TGF-β also triggers intracellular ROS release in ASMCs by upregulation of NADPH oxidase 4 (Nox4). However, the effect of TGF-β on the expression of key antioxidant enzymes and subsequently on oxidant/antioxidant balance is unknown. Moreover, the role of redox-dependent pathways in the mediation of the proinflammatory effects of TGF-β in ASMCs is unclear. In this study, we show that TGF-β induced the expression of Nox4 while at the same time inhibiting the expression of MnSOD and catalase. This change in oxidant/antioxidant enzymes was accompanied by elevated ROS levels and IL-6 release. Further studies revealed a role for Smad3 and phosphatidyl-inositol kinase-mediated pathways in the induction of oxidant/antioxidant imbalance and IL-6 release. The changes in oxidant/antioxidant enzymes and IL-6 release were reversed by the antioxidants N-acetyl-cysteine (NAC) and ebselen through inhibition of Smad3 phosphorylation, indicating redox-dependent activation of Smad3 by TGF-β. Moreover, these findings suggest a potential role for NAC in preventing TGF-β-mediated pro-oxidant and proinflammatory responses in ASMCs. Knockdown of Nox4 using small interfering RNA partially prevented the inhibition of MnSOD but had no effect on catalase and IL-6 expression. These findings provide novel insights into redox regulation of ASM function by TGF-β.
Improved retention and bone-tolmplant contact with fluoride-modified titanium implants. (2004)

Based on the biomechanical and histomorphometric data, the fluoride-modified titanium implants demonstrated a firmer bone anchorage than the unmodified titanium implants. These implants achieved greater bone integration than unmodified titanium implants after a shorter healing time.
Effects of Oxygenated Fuel and Cetane Improver on Exhaust Emission from Heavy-Duty DI Diesel Engines (1994)

<div class="htmlview paragraph">Smoke emission from single-cylinder DI and IDI diesel engines was shown to strongly depend on oxygen content in fuel regardless of oxygenate molecular structure. Thus, with cetane improver and oxygenate used in combination in a proportion determined from blending properties and potential cost for modern heavy-duty DI diesel engines were assessed. The combined use of nitrate type cetane improver with glycol ether type oxygenate reduced particulate, HC, and CO emission but not that of NOx. Particulate reduction depended on oxygenate content. Oxygenate at less than 5% with cetane improver seldom worsened volume-based fuel economy compared with the base hydrocarbon fuel.</div>
Cache Coherence for GPU Architectures (2014)

GPUs have become an attractive target for accelerating parallel applications and delivering significant speedups and energy-efficiency gains over multicore CPUs. Programming GPUs, however, remains challenging because existing GPUs lack the well-defined memory model required to support high-level languages such as C++ and Java. The authors tackle this challenge with Temporal Coherence, a simple and intuitive timer-based coherence framework optimized for GPU.
Towards enforcing on-the-fly policies in BYOD environments (2013)

The Bring Your Own Device (BYOD) paradigm is becoming extremely popular across all kind of organizations. In fact, employees are continually trying to incorporate their personal devices, e.g. smartphones and tablets, into the office to perform some of their work or simply to access the Internet with a device they trust or they are more familiar with. Unfortunately, several security issues may arise from all these external devices accessing the corporate network. To address these issues, in this paper we propose a framework that enforces on-the-fly instantiated policies inside organizations using trusted BYOD technologies. The proposed framework implements a role-based access control system based upon user identity and her current context. To this end, each user receives a specific policy from a server based upon the current role and context. The effective user identity is confirmed using OAuth 2.0, while the device integrity and policy enforcement is ensured by means of a on-device root-of-trust and an enforcer running on each device.
Review of fungicide resistance problems in Korea (2000)

Fungicide resistance study in Korea is still in its infancy, and most of those resistance studies are largely limited to newness of the detected resistant strains. In future, detection of fungicide-resistant strains has to be based on sensitivity distribution of pathogen populations to certain fungicides, and standard levels of certain fungicides for resistance should be determined under the basis of this data. Most of the early research on fungicide resistance in Korea has overlooked this point, and resulted in inconsistency and confusion for monitoring sensitivity shift of pathogen population among individual researchers. Fungicide resistance detected in vitro tests has to be documented in field trials by examining control efficacy against resistant and wild-type pathogen populations. Resistance detection in wife has to be correlated with lower activity in practice. Using this process, fungicide resistance will have a practical meaning. Fitness evaluation of resistant strains for survival is, in particular, of importance to determine the future stability of the resistance in the pathogen population. In fields, sensitivity change of pathogen populations should be carefully monitored with and without fungicide selection pressures to establish long-term management strategies against fungicide resistance. It is becoming an urgent task to provide information through research for designing and implementing successful counter-measures against fungicide resistance problems in Korea.
The effect of divalent cations on cell adhesion (1969)

The effect of several divalent cations on cell adhesion was estimated in monolayer cell cultures. The exclusion of the divalent cations (Ca and Mg) from Hanks' balanced salt solution resulted in rapid cell detachment from the glass substratum. Detached cells would reattach when these divalent cations again were introduced into the medium. Other divalent cations were found to have effects similar to those of calcium or magnesium on cell detachment and reattachment, with the exception of strontium which showed no interference with cell contact abilities.
Cross-lingual Language Model Pretraining (2019)

Recent studies have demonstrated the efficiency of generative pretraining for English natural language understanding. In this work, we extend this approach to multiple languages and show the effectiveness of cross-lingual pretraining. We propose two methods to learn cross-lingual language models (XLMs): one unsupervised that only relies on monolingual data, and one supervised that leverages parallel data with a new cross-lingual language model objective. We obtain state-of-the-art results on cross-lingual classification, unsupervised and supervised machine translation. On XNLI, our approach pushes the state of the art by an absolute gain of 4.9% accuracy. On unsupervised machine translation, we obtain 34.3 BLEU on WMT'16 German-English, improving the previous state of the art by more than 9 BLEU. On supervised machine translation, we obtain a new state of the art of 38.5 BLEU on WMT'16 Romanian-English, outperforming the previous best approach by more than 4 BLEU. Our code and pretrained models will be made publicly available.
Visualization of G Protein-coupled Receptor Trafficking with the Aid of the Green Fluorescent Protein (1997)

A chimeric protein consisting of the cholecystokinin receptor type A (CCKAR) and the green fluorescent protein (GFP) was used for studying receptor localization, internalization, and recycling in live cells in real time in four different cell lines. Fusion of the C terminus of the CCKAR to the N terminus of the GFP did not alter receptor ligand binding affinity, signal transduction, or the pattern of receptor surface expression and receptor-mediated cholecystokinin (CCK) internalization. The use of a new GFP mutant with increased fluorescence allowed the continuous observation of CCKAR-GFP in stably expressing cell lines. Newly obtained biologically active fluorescent derivatives of CCK were used for simultaneous observation of receptor and ligand trafficking in CHO, NIH/3T3, and HeLa cells stably expressing the fluorescent CCKAR and in transiently transfected COS-1 cells. Receptor internalization was predominantly ligand dependent in HeLa, COS-1, and CHO cells, but was mostly constitutive in NIH/3T3 cells, suggesting the existence of cell-specific regulation of receptor internalization. The CCKAR antagonists, L-364,718 and CCK 27-32 amide potently inhibited spontaneous internalization of the receptor. The average sorting time of CCK and the receptor in the endosomes was about 25 min. The receptor recycled back to the cell membrane with an average time of 60 min. While the ligands sorted to lysosomes, no receptor molecules could be detected there, and no receptor degradation was observed during recycling. These results demonstrate the usefulness of GFP tagging for real time imaging of G protein-coupled receptor trafficking in living cells and suggest that this technique may be successfully applied to the study of the regulation and trafficking mechanisms of other receptors.
Polyethylene Functionalized with Precisely Spaced Phosphonic Acid Groups (2009)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPolyethylene Functionalized with Precisely Spaced Phosphonic Acid GroupsKathleen L. Opper†, Birgit Fassbender‡, Gunther Brunklaus‡, Hans W. Spiess‡, and Kenneth B. Wagener*†View Author Information† The George and Josephine Butler Polymer Research Laboratory, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200‡ Max-Planck-Institut for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2009, 42, 13, 4407–4409Publication Date (Web):June 15, 2009Publication History Received22 April 2009Revised2 June 2009Published online15 June 2009Published inissue 14 July 2009https://pubs.acs.org/doi/10.1021/ma900884fhttps://doi.org/10.1021/ma900884frapid-communicationACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views1588Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Monomers,Organic compounds,Organophosphorus compounds,Polymers Get e-Alerts
Stereoselectivity of metathesis of various acyclic olefins with chromium-, molybdenum-, and tungsten-based catalysts (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselectivity of metathesis of various acyclic olefins with chromium-, molybdenum-, and tungsten-based catalystsM. Leconte and J. M. BassetCite this: J. Am. Chem. Soc. 1979, 101, 24, 7296–7302Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/ja00518a027https://doi.org/10.1021/ja00518a027research-articleACS PublicationsRequest reuse permissionsArticle Views328Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Correlation of Antimalarial Activity of Artemisinin Derivatives with Binding Affinity with Ferroprotoporphyrin IX (1997)

The antimalarial activity of a number of artemisinin derivatives, both newly synthesized and currently used as drugs, against Plasmodium falciparum in culture shows a correlation with their affinity of binding with ferroprotoporphyrin IX, as measured from the spectral change of the latter. The new C-16-functionalized artemisinin derivatives were obtained through a novel one-pot synthesis of artemisitene (2) from naturally abundant artemisinin (1), followed by Michael addition with nucleophiles. The correlation points to the biological significance of the interaction of these derivatives with ferroprotoporphyrin IX and may provide a basis for primary screening of peroxidic antimalarials of similar structures.
Memory efficient LDPC decoder design (2011)

Hardware complexity of LDPC decoders, which is caused by storage and processing of massive information, is the major reason that encumbers LDPC codes from widely application. Reducing the quantization word length of decoding information can effectively decrease the hardware complexity. But for the absolute value of information keeps increasing during decoding, short word length with finite quantization ranges will lead to serious saturation errors and damage decoding performance. Two quantization schemes is proposed in this paper to reduce the number of memory bits required by decoder design by using short word length while guarantee bit-error-rate (BER) performance. Results shows that these two quantization schemes can simplify the hardware complexity with very little loss of decoding performance.
Laboratory Tests to Determine the Chemical and Physical Characteristics of Propellant-Solvent-Fuel Oil Mixtures (1990)

Abstract : The military currently has an inventory of approximately 158,000 metric tons of propellants, explosives, and pyrotechnics, with a total of 249, 000 metric tons projected by the year 1993. This inventory includes obsolete conventional munitions and waste propellant generated during the manufacturing process. The current alternatives to storage are open-air burning, open-air detonation, or incineration to slowly reduce the inventory of these materials. The United States Army Toxic and Hazardous Materials Agency (USATHAMA) is currently coordinating a program to assess the feasibility of utilizing propellants dissolved in an appropriate solvent and further blended with fuel oil as supplemental fuel for Army industrial combustors. This report discusses the results from the initial phase of this program. (JES)
Video Salient Object Detection via Fully Convolutional Networks (2017)

This paper proposes a deep learning model to efficiently detect salient regions in videos. It addresses two important issues: 1) deep video saliency model training with the absence of sufficiently large and pixel-wise annotated video data and 2) fast video saliency training and detection. The proposed deep video saliency network consists of two modules, for capturing the spatial and temporal saliency information, respectively. The dynamic saliency model, explicitly incorporating saliency estimates from the static saliency model, directly produces spatiotemporal saliency inference without time-consuming optical flow computation. We further propose a novel data augmentation technique that simulates video training data from existing annotated image data sets, which enables our network to learn diverse saliency information and prevents overfitting with the limited number of training videos. Leveraging our synthetic video data (150K video sequences) and real videos, our deep video saliency model successfully learns both spatial and temporal saliency cues, thus producing accurate spatiotemporal saliency estimate. We advance the state-of-the-art on the densely annotated video segmentation data set (MAE of .06) and the Freiburg-Berkeley Motion Segmentation data set (MAE of .07), and do so with much improved speed (2 fps with all steps).This paper proposes a deep learning model to efficiently detect salient regions in videos. It addresses two important issues: 1) deep video saliency model training with the absence of sufficiently large and pixel-wise annotated video data and 2) fast video saliency training and detection. The proposed deep video saliency network consists of two modules, for capturing the spatial and temporal saliency information, respectively. The dynamic saliency model, explicitly incorporating saliency estimates from the static saliency model, directly produces spatiotemporal saliency inference without time-consuming optical flow computation. We further propose a novel data augmentation technique that simulates video training data from existing annotated image data sets, which enables our network to learn diverse saliency information and prevents overfitting with the limited number of training videos. Leveraging our synthetic video data (150K video sequences) and real videos, our deep video saliency model successfully learns both spatial and temporal saliency cues, thus producing accurate spatiotemporal saliency estimate. We advance the state-of-the-art on the densely annotated video segmentation data set (MAE of .06) and the Freiburg-Berkeley Motion Segmentation data set (MAE of .07), and do so with much improved speed (2 fps with all steps).
A new technique for quality scalable video coding with H.264 (2005)

In this paper, we provide a technique that allows H264/AVC to achieve quality scalable coding by allowing the coder to produce different coded motion qualities. This technique is called block ordering scalability. It realizes scalability by exploiting the existing building blocks of the standard. It may need minor changes of the current standard, but in its simple form, presented here, it does not need any change at all. The blocks carrying the updating picture information are ordered according to their importance into different slices. This reordering allows realizing a gradual refinement of the quality of coded pictures. An implementation of such a system is achieved by analyzing the motion of a given picture to determine the most important blocks to code for basic quality and the less important ones used for enhancement. In this case, scalability affects the quality of the reproduced motion. This way of coding the enhancement blocks allows achieving rate-adaptive coding. Many experimental results that show the efficiency of the technique are provided.
Treatment of Early-Stage Mycosis Fungoides With Twice-Weekly Applications of Mechlorethamine and Topical Corticosteroids (2005)

A regimen of twice-weekly applications of mechlorethamine and betamethasone cream is an effective treatment for early-stage mycosis fungoides. The decreased frequency of applications provides an advantage to the patient by being easy to use with limited adverse effects.
Systemic treatment of breast cancer. Two decades of progress. (2006)

Over the past 20 years we have witnessed the emergence of a new generation of aromatase inhibitors as valuable antiestrogens in the management of both advanced and early-stage breast cancer. In addition, the list of cytotoxic chemotherapeutic agents useful in the control of breast cancer has grown considerably. The emergence ofanthracyclines was a major chemotherapeutic step forward in the 1980s, and the taxanes have clearly been the agents with the greatest impact on breast cancer treatment over the past decade. The end of the past 2 decades has been characterized by a greater understanding of the molecular biology of breast cancer, rational drug design, and the development of agents that disrupt specific cellular targets and pathways. The development of better prognostic and predictive assays that employ a panel of genes involved in the malignant and metastatic phenotype promises to allow clinicians to better select patients who could forgo adjuvant chemotherapy. Finally, adjunctive and supportive therapy of breast cancer has evolved substantially over the past 20 years. This review will highlight some of the landmark accomplishments during this time, and offer a glimpse at where we might be 20 years from now.