gebhart/patrepeval huggingface dataset:
5-Fluoro-2-methyl-<i>N</i>-[4-(5<i>H</i>-pyrrolo[2,1-<i>c</i>]- [1,4]benzodiazepin-10(11<i>H</i>)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist with Selectivity for V<sub>2</sub>Receptors (1998)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]- [1,4]benzodiazepin-10(11H)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985): An Orally Active Arginine Vasopressin Antagonist with Selectivity for V2 ReceptorsJ. Donald Albright, Marvin F. Reich, Efren G. Delos Santos, John P. Dusza, Fuk-Wah Sum, Aranapakam M. Venkatesan, Joseph Coupet, Peter S. Chan, Xun Ru, Hossein Mazandarani, and Trina BaileyView Author Information Wyeth-Ayerst Research, Pearl River, New York 10965, and Wyeth-Ayerst Research, Princeton, New Jersey 08543-8000 Cite this: J. Med. Chem. 1998, 41, 14, 2442–2444Publication Date (Web):June 16, 1998Publication History Received23 March 1998Published online16 June 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/jm980179chttps://doi.org/10.1021/jm980179crapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1035Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antagonists,Receptors,Rodent models,Screening assays,Selectivity Get e-Alerts
Measurement of Radial Transport in Slug Flow Using Enzyme Tubes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasurement of Radial Transport in Slug Flow Using Enzyme TubesCsaba Horvath, Barry A. Solomon, and Jean-Marc EngasserCite this: Ind. Eng. Chem. Fundamen. 1973, 12, 4, 431–439Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/i160048a006https://doi.org/10.1021/i160048a006research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Large-scale storage of hydrogen (2019)

The large-scale storage of hydrogen plays a fundamental role in a potential future hydrogen economy. Although the storage of gaseous hydrogen in salt caverns already is used on a full industrial scale, the approach is not applicable in all regions due to varying geological conditions. Therefore, other storage methods are necessary. In this article, options for the large-scale storage of hydrogen are reviewed and compared based on fundamental thermodynamic and engineering aspects. The application of certain storage technologies, such as liquid hydrogen, methanol, ammonia, and dibenzyltoluene, is found to be advantageous in terms of storage density, cost of storage, and safety. The variable costs for these high-density storage technologies are largely associated with a high electricity demand for the storage process or with a high heat demand for the hydrogen release process. If hydrogen is produced via electrolysis and stored during times of low electricity prices in an industrial setting, these variable costs may be tolerable.
Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients (2006)

In this multicenter trial, treatment with 20 mg/d of rimonabant plus diet for 2 years promoted modest but sustained reductions in weight and waist circumference and favorable changes in cardiometabolic risk factors. However, the trial was limited by a high drop-out rate and longer-term effects of the drug require further study. Clinical Trials Registration ClinicalTrials.gov Identifier: NCT00029861.
Fast Alternating Linearization Methods for Minimizing the Sum of Two Convex Functions (2009)

We present in this paper first-order alternating linearization algorithms based on an alternating direction augmented Lagrangian approach for minimizing the sum of two convex functions. Our basic methods require at most $O(1/ε)$ iterations to obtain an $ε$-optimal solution, while our accelerated (i.e., fast) versions of them require at most $O(1/\sqrtε)$ iterations, with little change in the computational effort required at each iteration. For both types of methods, we present one algorithm that requires both functions to be smooth with Lipschitz continuous gradients and one algorithm that needs only one of the functions to be so. Algorithms in this paper are Gauss-Seidel type methods, in contrast to the ones proposed by Goldfarb and Ma in [21] where the algorithms are Jacobi type methods. Numerical results are reported to support our theoretical conclusions and demonstrate the practical potential of our algorithms.
Update: Management of Parapneumonic Effusions (2003)

Whenever a patient with a pleural effusion is evaluated, the possibility of a parapneumonic effusion should be considered. When the diaphragms cannot be completely visualized or loculated pleural fluid appears to be present, the possibility of pleural fluid should be assessed with ultrasound or lateral decubitus radiographs. If there is more than a minimal amount of pleural fluid, the fluid should be sampled to determine if there are any poor prognostic factors present (pus, positive gram stain, glucose less than 40 mg/dL, pH less than 7.20, positive culture or lactate dehydrogenase greater than 3 times the upper limit of normal for serum). The fluid is best sampled with a therapeutic thoracentesis. If the fluid recurs, a second therapeutic thoracentesis is performed if any of the poor prognostic factors were present at the first thoracentesis. If the fluid cannot be removed with the therapeutic thoracentesis, either tube thoracostomy with the instillation of fibrinolytics or thoracoscopy should be performed. If the lung does not expand with thoracoscopy, thoracotomy with decortication should be performed. Many decortications are now being done via thoracoscopy. Open drainage procedures are reserved for those patients who are too ill to undergo thoracoscopy or thoracotomy. The definitive procedure should be performed within 10 days of the patient’s initial hospitalization.
The Wife's Tale: Frances, Lady Nelson and the break‐up of her marriage (2003)

(2003). The Wife's Tale: Frances, Lady Nelson and the break‐up of her marriage. Journal for Maritime Research: Vol. 5, No. 1, pp. 121-142.
THE ANATOMICAL BASIS OF SYMPTOMATIC HEMIDYSTONIA (1985)

Twenty-eight patients with focal (arm or leg) or hemidystonia due to tumour, arteriovenous malformation, infarction, haemorrhage or hemiatrophy are described. All had typical dystonic movements and/or postures, identical to those seen in idiopathic (primary) torsion dystonia. The site(s) of the lesion responsible, as defined by CT (computerized tomography) scan or pathological examination, was in the contralateral caudate nucleus, lentiform nucleus (particularly the putamen) or thalamus, or in a combination of these structures. Review of 13 other patients in the literature with hemidystonia and lesions defined by CT scan, and of 7 other patients with pathologically discrete lesions associated with hemidystonia, also indicated involvement of these structures. Dystonia may be due to abnormal input from thalamus to premotor cortex, due to lesions either of the thalamus itself, or of the striatum projecting by way of the globus pallidus to the thalamus.
All The Catalytic Active Sites of MoS<sub>2</sub> for Hydrogen Evolution (2016)

MoS<sub>2</sub> presents a promising low-cost catalyst for the hydrogen evolution reaction (HER), but the understanding about its active sites has remained limited. Here we present an unambiguous study of the catalytic activities of all possible reaction sites of MoS<sub>2</sub>, including edge sites, sulfur vacancies, and grain boundaries. We demonstrate that, in addition to the well-known catalytically active edge sites, sulfur vacancies provide another major active site for the HER, while the catalytic activity of grain boundaries is much weaker. The intrinsic turnover frequencies (Tafel slopes) of the edge sites, sulfur vacancies, and grain boundaries are estimated to be 7.5 s<sup>-1</sup> (65-75 mV/dec), 3.2 s<sup>-1</sup> (65-85 mV/dec), and 0.1 s<sup>-1</sup> (120-160 mV/dec), respectively. We also demonstrate that the catalytic activity of sulfur vacancies strongly depends on the density of the vacancies and the local crystalline structure in proximity to the vacancies. Unlike edge sites, whose catalytic activity linearly depends on the length, sulfur vacancies show optimal catalytic activities when the vacancy density is in the range of 7-10%, and the number of sulfur vacancies in high crystalline quality MoS<sub>2</sub> is higher than that in low crystalline quality MoS<sub>2</sub>, which may be related with the proximity of different local crystalline structures to the vacancies.
Pathogenesis of Graves' Ophthalmopathy (1993)

Ophthalmopathy is a potentially disfiguring and sight-threatening component of Graves' disease. It is clinically evident in 25 to 50 percent of patients with Graves' hyperthyroidism and occurs occasionally in patients with Hashimoto's thyroiditis and in those with Graves' disease but no evident thyroid disease1. At present, ophthalmopathy is not preventable, and treatment options for established, symptomatic disease are limited. To develop new strategies for the treatment and prevention of Graves' ophthalmopathy, a better understanding of its pathogenesis is necessary. In this paper we review studies aimed at identifying the pathogenic mechanisms that lead to Graves' ophthalmopathy.Clinical FeaturesPatients . . .
Effect of ejector dilutors on measurements of automotive exhaust gas aerosol size distributions (2009)

Ejector dilutors have long been used for automotive exhaust particle sampling, as they can offer a low-cost option for stable dilution. In an ejector dilutor, pressurized air expanding in the periphery of a nozzle draws in and mixes with an exhaust sample which is then led to analytical equipment. The combination of processes involved may lead to particle losses which can affect the measurement. This study examines the losses of diesel exhaust particles of different characteristics (nucleation mode, non-volatile accumulation mode, internally and externally mixed accumulation mode) when these are sampled through an ejector dilutor. A scanning mobility particle sizer (SMPS), an electrical low-pressure impactor and a diffusion charger were used as analytical equipment to characterize losses with different instruments. Particle losses were found negligible for all practical applications of diesel exhaust aerosol sampling. Also, the sampling outlet and the operating pressure of the ejector dilutor were found to have a non-measurable effect on the distribution shape. Some variation of the labile nucleation mode particles was attributed to evaporation within the SMPS rather than an ejector effect, and this was confirmed by sampling solid NaCl particles in the same size range. The study further confirms the usability of ejector dilutors for exhaust particle sampling and dilution.
Expression and function of Fas antigen on activated murine B cells (1996)

We have studied the expression and function of Fas antigen on murine B lymphocytes. While Fas was present on only a few B cells in the bone marrow, spleen, lymph node or peripheral blood, its expression could be strongly up-regulated by stimulation with soluble CD40 ligand (CD40L). Treatment with anti-IgM and interleukin-4 (IL-4) alone did not induce significant Fas expression but enhanced CD40L-mediated up-regulation of Fas expression. The T cell-derived signal via CD40 is therefore a potent inducer of Fas expression by B lymphocytes. The sensitivity to Fas-mediated apoptosis was found to depend on the duration of B cell activation. B cells activated for 1 day were resistant to Fas-mediated cell death, whereas B cells activated for 3 days were relatively sensitive. Interestingly, different sensitivity to Fas-mediated death signal was observed in 2-day activated B cells. It was found that B cells stimulated with CD40 L alone were more sensitive to Fas-mediated apoptosis than were cells stimulated with CD40L plus anti-IgM or IL-4, and in particular, the combination of the two. The greater sensitivity exhibited by B cells stimulated with CD40L alone seems to be related to limited activation of these cells in the absence of additional stimulation. Co-stimulation of B cells in the presence of CD40L and anti-Fas antibody resulted initially in activation of B lymphocytes, as reflected by the expression of activation markers and cell growth, but this was followed by growth inhibition and cell death. The data demonstrate that the B cell response can be regulated positively and negatively by signaling through CD40 and Fas antigens, respectively.
Hydrosilane and bismuth-accelerated palladium catalyzed aerobic oxidative esterification of benzylic alcohols with air (2012)

In a palladium-catalyzed oxidative esterification, hydrosilane can serve as an activator of palladium catalyst with bismuth, thus leading to a novel ligand- and silver-free palladium catalyst system for facile oxidative esterification of a variety of benzylic alcohols in good yields.
An End-to-End Automation Framework for Mobile Network Testbeds (2019)

This paper describes the end-to-end automation framework developed as part of the TRIANGLE project. The TRIANGLE project is devoted to the benchmarking of apps and devices in mobile networks. For that purpose, it is needed to ensure the repeatability in the behaviour of all the components of the mobile network during the execution of the same test. This is why one of the main objectives of the project was to develop an end-to-end automation framework to provide repeatable testing. This paper describes in detail the design and the implementation of the framework.
Cross-Layer Throughput Optimization With Power Control in Sensor Networks (2011)

In wireless sensor networks, transmission power has a significant impact on network throughput as wireless interference increases with transmission power, and interference negatively impacts the network throughput. In this paper, we try to improve the network throughput through cross-layer optimization. We first present two algorithms to compute the transmission power of each node with the objectives of minimizing the total transmission power and minimizing the total interference, respectively, from which we can obtain a network topology that ensures a connected path from each source to the sink; then, we compute the maximum achievable throughput from the obtained topology by using joint routing and link rate control. The power control algorithms can generate symmetric links or asymmetric links if so desired. Based on different link models, we use different algorithms to compute the maximum achievable throughput. Since computing the maximum throughput is an NP-hard problem, we use efficient heuristics that use a sufficient condition instead of the computationally expensive-to-get optimal condition to capture the mutual conflict relation in a collision domain. The formal proof for the sufficient condition is provided, and the proposed algorithms are compared with previous work. Simulation results show that the proposed algorithms improve the network throughput and reduce the energy consumption, with significant improvement over previous work on both aspects.
Steam And Gas Push (SAGP) (1997)

Abstract While heavy oils can be produced by horizontal wells at economic rates, the extent of recovery is small because of loss of drive and/or watering out of the production. In typical cases a recovery of only a few percent of the OOIP is achievable. SAGD overcomes these problems by allowing high production rates with only a small drawdown. The reservoir pressure is maintained by the injection of the steam and operation without steam coning is practicable; very high recoveries are normally obtained. In conventional SAGD the depleted reservoir becomes filled with steam at the saturation temperature corresponding to the operating pressure - typically 200 to 250 °C. Large quantities of steam are required to heat the depleted reservoir, the reservoir surrounding the steam chamber and, particularly with thin reservoirs, the overburden. With high quality, thick reservoirs SOR's of about 2.5 to 3 are obtained but in thinner reservoirs, and in reservoirs with lower oil saturations, SOR's are much higher and the process is uneconomic. The problem is compounded by the steam chamber having long sloping boundaries that extend the heated area. In this paper it is shown that it is not necessary for the whole steam chamber to be at a uniform high temperature. Only the lowest part, where the coning tendency is greatest, needs to be at the highest temperature. High temperatures in the upper part of the chamber are an " "overkill" that results in wasted heat. It is proposed that the SAGD process be modified by injecting non-condensible gas, such as natural gas, with the steam from a horizontal injection well somewhat above the producer. Gas accumulates in the chamber above the injector and lowers the temperature. Considerable savings can be made by this approach without a substantial decline in performance. In one example it is shown that the heat stored in the chamber per cubic meter of produced oil will be only 62 % of that for conventional SAGD and that the heat lost to the overburden will be a very much smaller fraction. This concept should greatly extend the range of reservoirs that can be produced economically. Introduction For the efficient and economic recovery of heavy oils it is necessary to employ means for facilitating the flow of the viscous fluid through the reservoir. Not only is it necessary to offset the effect of their very high viscosities by providing extended contact and/or viscosity reduction by heating, but it is also necessary to maintain the drive needed to move the oil as the reservoir becomes depleted. Some approaches such as the use of long horizontal wells or cyclic steaming are effective in promoting flow but only produce limited recovery. Steamflooding and, more recently, SAGD also maintain reservoir drive and allow high recoveries. However, because of their considerable heat requirements, these processes are limited in their economic use to higher quality reservoirs. It is the purpose of this paper to describe a new concept for the production of heavy oils that is a modification of the SAGD process[1, 2, 3, 4,5].
LAS ALMAGRAS DE ALMIZARAQUE: COMPOSICIÓN MINERALÓGICA, TECNOLOGÍA Y PROCESO DE COCCIÓN (1993)

Revista especializada en la publicación de trabajos originales de investigación en Prehistoria y Arqueología. Es la publicación periódica más antigua de la UAM. Su enfoque abierto a cualquier temática y época pasada, hasta la más cercana, que sea objeto de la Ciencia arqueológica se abre a una decidida proyección internacional en la que quiere basar su futuro inmediato.
Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice (2009)

Neurodegeneration in an inherited form of ALS is non-cell-autonomous, with ALS-causing mutant SOD1 damage developed within multiple cell types. Selective inactivation within motor neurons of an ubiquitously expressed mutant SOD1 gene has demonstrated that mutant damage within motor neurons is a determinant of disease initiation, whereas mutant synthesis within neighboring astrocytes or microglia accelerates disease progression. We now report the surprising finding that diminished synthesis (by 70%) within Schwann cells of a fully dismutase active ALS-linked mutant (SOD1(G37R)) significantly accelerates disease progression, accompanied by reduction of insulin-like growth factor 1 (IGF-1) in nerves. Coupled with shorter disease duration in mouse models caused by dismutase inactive versus dismutase active SOD1 mutants, our findings implicate an oxidative cascade during disease progression that is triggered within axon ensheathing Schwann cells and that can be ameliorated by elevated dismutase activity. Thus, therapeutic down-regulation of dismutase active mutant SOD1 in familial forms of ALS should be targeted away from Schwann cells.
Seasonal effects on guayule resin composition (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSeasonal effects on guayule resin compositionWilliam W. Schloman Jr., Donald J. Garrot Jr., Dennis T. Ray, and Donald J. BennettCite this: J. Agric. Food Chem. 1986, 34, 2, 177–179Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/jf00068a005https://doi.org/10.1021/jf00068a005research-articleACS PublicationsRequest reuse permissionsArticle Views254Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts