gebhart/patrepeval huggingface dataset:
A novel immunosuppressive factor in bovine colostrum blocks activation of the interleukin 2 gene enhancer at the NFAT site (1996)

A factor in bovine colostrum (colostrum inhibitory factor, CIF) inhibits interleukin 2 (IL2) production in activated T helper cells by blocking the accumulation of IL2 mRNA. To determine whether CIF blocks at the level of IL2 transcription, we introduced reporter plasmids into the human T leukemia cell line Jurkat by transient transfection. These contained the luciferase gene under the control of either the human IL2 upstream enhancer region (segments -326 to +45) or three repeats of the NFAT element contained within it (segments -255 to -285). Expression of luciferase in these cells was induced by phorbol myristate acetate plus a calcium ionophore. CIF inhibited induction of either construct as did cyclosporine, which is known to block activation of the NFAT element. CIF failed to inhibit several other enhancer elements. The NFAT-controlled luciferase gene system distinguishes CIF from other T cell inhibitory activities present in colostrum, in particular, TGF beta 1 and TGF beta 2 and the glucocorticoids. Stably transfected Jurkat cells behaved similarly to the transiently transfected ones with respect to inhibition by CIF and cyclosporine. The NFAT-luc assay is a useful technique for the rapid, sensitive measurement of CIF or other immunosuppressants with a similar mode of action.
Studies on the interaction between actin and cofilin purified by a new method (1988)

Cofilin is a 21,000-Mr actin-binding protein that widely exists in mammalian tissues. (1) A new purification procedure for porcine brain cofilin has been developed that involves (NH4)2SO4 fractionation and sequential chromatographies on Toyo Pearl and butyl-Toyo Pearl hydrophobic columns, hydroxyapatite, phosphocellulose and Sephadex G-75 gel-filtration columns. The purified cofilin bound to F-actin and increased the amount of G-actin to a limited extent, as previously reported [Nishida, Maekawa & Sakai (1984) Biochemistry 23, 5307-5313]. (2) The binding of cofilin to F-actin was scarcely affected by Mg2+, Ca2+ or by calmodulin. However, the binding was diminished by increasing concentrations of KCl, but was only slightly affected by temperature. (3) Cofilin and either alpha-actinin or filamin could bind to F-actin simultaneously with some competition, but the binding of caldesmon to F-actin was markedly inhibited by cofilin. Phalloidin inhibited the binding of cofilin to F-actin, and protected F-actin from depolymerization by cofilin.
Advances in biomedical engineering : results of the 4th EC Medical and Health Research Programme (1993)

Diagnostics methods and monitoring - monitoring systems, imaging techniques treatment and rehabilitation technical and clinical evaluation.
A framework of 3D video coding using view synthesis prediction (2012)

The advanced 3D video system employs the multi-view video plus depth (MVD) format to support free-viewpoint navigation and comfortable 3D video. Therefore, the prediction structure of the multi-view video coding (MVC) can be used for 3D video coding. The view synthesis prediction method is designed to exploit inter-view correlation using the virtual view generation; hence it is suitable for 3D video coding. In this paper, we propose an efficient framework for 3D video coding using view synthesis prediction to compress multi-view color and depth data simultaneously. We designed the coding procedure of MVD data with four types of view synthesis methods according to the view position. The experimental results showed that the proposed framework improved the coding performance at most 0.9 dB for the multi-view color videos.
0.79" single panel liquid crystal on silicon backplane IC with 1408 8 b DACs for HDTV applications (2003)

The architecture and circuit design of a single panel liquid crystal on silicon (LCoS) backplane IC that includes 1408 /spl times/ 844 pixels and drives 8 color sub-frames/one video frame is described. There are 1408 DACs to improve picture uniformity and one analog frame buffer to reduce video bandwidth. Each pixel has 256 gray levels and 12 /spl mu/m pitch. The IC, fabricated in UMC 0.35 /spl mu/m 5M LCoS technology, is used successfully in projection applications.
Certificate Revocation Guard (CRG): An Efficient Mechanism for Checking Certificate Revocation (2016)

In the Public Key infrastructure (PKI) model, digital certificates play a vital role in securing online communication. Communicating parties exchange and validate these certificates, the validation fails if a certificate has been revoked. In this paper we propose the Certificate Revocation Guard (CRG) to efficiently check certificate revocation while minimising bandwidth, latency and storage overheads. CRG is based on OCSP, which caches the status of certificates locally. CRG could be installed on the user's machine, at the organisational proxy or even at the ISP level. Compared to a naive approach (where a client checks the revocation status of all certificates in the chain on every request), CRG decreases the bandwidth overheads and network latencies by 95%. Using CRG incurs 69% lower storage overheads compared to the CRL method. Our results demonstrate the effectiveness of our approach to improve certificate revocation.
MUSIC ALGORITHM FOR A DIRECTIONAL BOREHOLE RADAR USING A CONFORMAL ARRAY ANTENNA (1998)

In single-hole borehole radars, which use a single borehole, a direct wave from transmitter influences estimation of a target position. In this paper, we propose a signal processing method to reduce the direct wave for estimating a three-dimensional position with an array in a borehole. First, we show that a direct wave from a transmitter illuminates an array in a borehole, and it can influence estimation of a target near a used borehole. We cannot theoretically predict characteristics of the direct wave, since mechanism of the direct wave is complicated, and we cannot easily reduce the direct wave. We show that introduction of the guided wave model, which was made with experimental results of estimation of wave number of the direct wave, into an array signal processing is effective in reduction of guided waves. We apply the proposed algorithm to the data, which was obtained in borehole radar measurement. As a result of the data analysis, we could successfully locate the reflector in spite of existence of direct waves. Key words: three-dimensional position estimation, borehole radar, array, guided wave, MUSIC algorithm
An example of a nonlinear regulator (1984)

The purpose of this note is to use the concept of feedback equivalence to linear controllable systems in order to design a nonlinear regulator for a synchronous generator connected to an infinite bus. The design of the regulator will show how recently developed theorems in the area of geometric nonlinear control theory approach a power system problem, offering an interesting solution.
Coaxial probes for scanning near‐field microscopy (1999)

This paper deals with the development of coaxial aperture tips integrated in a cantilever probe for combined scanning near-field infrared microscopy and scanning force microscopy. A fabrication process is introduced that allows the batch fabrication of hollow metal aperture tips integrated on a silicon cantilever. To achieve the coaxial tip arrangement a metal rod is deposited inside the hollow tip using the focused ion beam technique. Theoretical calculations with a finite integration code were performed to study the transmission characteristics of coaxial tips in comparison with conventional aperture probes. In addition, the influence of the geometrical design parameters of the coaxial probe on its optical behaviour is investigated.
Navigation strategy and path planning for autonomous road crossing by outdoor mobile robots (2011)

This paper describes the navigation strategy and path planning methods for autonomous road crossing by outdoor mobile robots in urban environments. Road-crossing is the part of outdoor robot navigation when a robot, while traveling along pedestrian sidewalks, approaches an intersection or a road crossing and needs to autonomously cross to reach the intended destination. In this work, the robot first autonomously travels along pedestrian sidewalks. For this, instead of using a pre-supplied navigational map, we endow the robot with the level of autonomy required such that it can spontaneously detect sidewalks and perceive a trajectory to navigate. While traveling along this trajectory, the robot performs real time detection of pedestrian push-button boxes. If a button box is detected, the robot deviates from the original trajectory and autonomously navigates to it. Next, using the detected button box as a landmark, the robot approaches the pedestrian crossing. It finally performs vision-based detection of the zebra crossings and generates the trajectory required to cross the road at a green signal. We demonstrate these methods are feasible by performing experiments with a custom built outdoor mobile robot using experimental conditions based on an actual pedestrian crossing in our university campus.
Analysis of the Spatial Distribution of Identical and Two Distinct Virus Populations Differently Labeled with Cyan and Yellow Fluorescent Proteins in Coinfected Plants (2007)

ABSTRACT Apple latent spherical virus (ALSV) expressing yellow and cyan fluorescent proteins (ALSV-YFP and ALSV-CFP) was used to investigate the distribution of identical virus populations in coinfected plants. In Chenopodium quinoa plants inoculated with a mixture of ALSV-YFP and ALSV-CFP, fluorescence from YFP and CFP was always distributed separately in both inoculated and upper uninoculated leaves. Inoculation of each ALSV-YFP and ALSV-CFP to different leaves of a C. quinoa plant resulted in the separate distribution of each virus population among different upper leaves. When C. quinoa leaves were first inoculated with ALSV-CFP and then ALSV-YFP was reinoculated into the same leaves at various times after the first inoculation, ALSV-YFP infected only tissues where ALSV-CFP infection had not been established. The spatial separation was also found in Nicotiana benthamiana leaves coinoculated with Bean yellow mosaic virus (BYMV)-YFP and BYMV-CFP. In contrast, both YFP and CFP fluorescence signals were observed in the same tissues of N. benthamiana leaves mixed infected with ALSV-YFP and BYMV-CFP. YFP fluorescence from ALSV-YFP in mixed-infected leaves was brighter and longer than in leaves infected with ALSV-YFP singly.
A New Mobile Streaming System Base-On Http Live Streaming Protocol (2011)

Proposed a new Mobile Streaming System that can support live broadcasts, video on demand an time- shifted base-on Http Live Streaming Protocol, with a cross-platform client, litter constraints of server network, and user accessing media data from web server. Media encoding format is mpeg + mp3 , using m3u8 file format to index and organize the media data.
Towards Targeted MRI: New MRI Contrast Agents for Sialic Acid Detection (2004)

The detection of sialic acid in living systems is of importance for the diagnosis of several types of malignancy. We have designed and synthesized two new lanthanide ion ligands (L1 and L2) that are capable of molecular recognition of sialic acid residues. The basic structure of these ligands consists of a DTPA-bisamide (DTPA, diethylenetriamine pentaacetic acid) whose amide moieties each bear both a boronic function for interaction with the diol groups in the side chain of sialic acid, and a functional group that is positively charged at physiologic pH values and is designed to interact with the carboxylate anion of sialic acid. The relaxometric properties of the Gd3+ complexes of these two ligands were evaluated. The relaxivity of the GdL1 complex has a significant second-sphere contribution at pH values above the pKa of its phenylboronic acid moiety. The interaction of the Gd3+ complexes of L1 and L2 with each of several saccharides was investigated by means of a competitive fluorescent assay. The results show that both complexes recognize sialic acid with good selectivity in the presence of other sugars. The adduct formed by GdL2 with sialic acid has the higher conditional formation constant (50.43+/-4.61 M(-1) at pH 7.4). The ability of such complexes to recognize sialic acid was confirmed by the results of a study on the interaction of corresponding radiolabeled complexes (153SmL1 and 153SmL2) with C6 glioma rat cells. 153SmL2 in particular is retained on the cell surface in significant amounts.
Una última aplicación del «doble control de transparencia»: jurisprudencia agotada e intervención legislativa pendiente (2017)

espanolLa Sentencia del Tribunal Supremo (Sala Primera) de 9 de marzo de 2017 aplica la doctrina del «doble control de transparencia» a una clausula suelo inserta en un contrato de prestamo con garantia hipotecaria. Rechaza el caracter no transparente de la clausula, por haberse acreditado su comprensibilidad real por el consumidor. No obstante, el pronunciamiento pone de manifiesto la necesidad de una intervencion legislativa que prevenga a tiempo la falta de transparencia en la contratacion con consumidores. EnglishThe Judgment of the Supreme Court (First Chamber) of March 3, 2017 applies the doctrine of «double control of transparency» to a floor clause inserted in a credit agreement. It rejects the non-transparent nature of the clause, because its actual comprehensibility has been established by the consumer. However, the ruling shows the need for legislative intervention to prevent the lack of transparency in contracting with consumers in time.
Design of Compact, Single-Layered Substrate Integrated Waveguide Filtenna With Parasitic Patch (2019)

A compact, single-layered substrate-integrated waveguide (SIW) filtenna with parasitic patch is synthesized and designed. A half-mode substrate-integrated rectangular cavity (HMSIRC) is adopted as the first stage resonator to reduce the circuit size. A parasitic patch functioning as the last stage resonator as well as the radiator is arranged closely to the HMSIRC so as to enhance the operational bandwidth and facilitate the filtering performance. Two broadside radiation nulls are realized at both the upper and lower band-edges to sharpen the band-edge roll-off rate: one is generated by the interaction between the HMSIRC and the parasitic patch, and the other is introduced by placing two pairs of shorting posts under the parasitic patch. The standard filter synthesis technology is utilized to guide the filtenna design. The optimized prototype was fabricated and measured. The measured results, in good agreement with simulated values, indicated the proposed filtenna provides a 5.1% fractional bandwidth, a maximum realized gain of 6.3 dBi, and a flat passband gain response along with excellent out-of-band selectivity, even with ultralow profile 0.015 λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> and small volume 0.005 λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> .
Discriminative Accuracy of Physician and Nurse Predictions for Survival and Functional Outcomes 6 Months After an ICU Admission (2017)

ICU physicians' and nurses' discriminative accuracy in predicting 6-month outcomes of critically ill patients varied depending on the outcome being predicted and confidence of the predictors. Further research is needed to better understand how clinicians derive prognostic estimates of long-term outcomes.
Critical appraisal of lurasidone in the management of schizophrenia (2012)

Lurasidone is a new atypical antipsychotic in the benzoisothiazoles class of chemicals. Like most second-generation antipsychotics it is a full antagonist at dopamine D(2) and serotonin 5-HT(2A) receptors, and is a partial agonist at 5-HT(1A) receptors, a property shared by some but not all older agents. It has much greater affinity for 5-HT(7) subtype receptors than other atypical antipsychotics. Pharmacokinetic studies showed that lurasidone is reasonably rapidly absorbed, with bioavailability appearing to be increased by food. Lurasidone undergoes extensive metabolism to a number of metabolites, some of which retain pharmacological activities. Metabolism is mainly by CYP3A4, resulting in steady-state concentrations that vary between individuals and are potentially affected by strong inducers and inhibitors of this enzyme. Short-term clinical trials have demonstrated the efficacy of lurasidone in acute schizophrenia, with doses of 40 and 80 mg/day giving significant improvements from baseline in the PANSS and BPRS scores. The most common adverse events are nausea, vomiting, akathisia, dizziness, and sedation, with minimal increases in the risk of developing metabolic syndrome. Lurasidone did not raise the risk of QTc interval prolongation, although additional studies are required. Long-term trials are also needed to assess the risk of new-onset diabetes. Ongoing trials in patients with bipolar disorder are being completed but, again, efficacy and safety have been investigated only in a few short-term clinical trials.
Spectrophotometric Determination of Glyoxylic Acid with o-Aminobenzaldehyde and Glycine, and Its Application to Enzyme Assay (1973)

Journal Article Spectrophotometric Determination of Glyoxylic Acid with o-Aminobenzaldehyde and Glycine, and Its Application to Enzyme Assay Get access Kenji Soda, Kenji Soda Institute for Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Seizen Toyama, Seizen Toyama Institute for Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan Present address: Department of Agricultural and Biological Chemistry, Ryukyu University, Naha, Okinawa 903, Japan Search for other works by this author on: Oxford Academic Google Scholar Haruo Misono, Haruo Misono Institute for Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Toshiko Hirasawa, Toshiko Hirasawa Institute for Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Kozi Asada Kozi Asada Research Institute for Food Science, Kyoto University, Uji, Kyoto-Fu 611, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 37, Issue 6, 1 June 1973, Pages 1393–1400, https://doi.org/10.1080/00021369.1973.10860828 Published: 01 June 1973 Article history Received: 13 November 1972 Published: 01 June 1973
CollaGAN: Collaborative GAN for Missing Image Data Imputation (2019)

In many applications requiring multiple inputs to obtain a desired output, if any of the input data is missing, it often introduces large amounts of bias. Although many techniques have been developed for imputing missing data, the image imputation is still difficult due to complicated nature of natural images. To address this problem, here we proposed a novel framework for missing image data imputation, called Collaborative Generative Adversarial Network (CollaGAN). CollaGAN convert the image imputation problem to a multi-domain images-to-image translation task so that a single generator and discriminator network can successfully estimate the missing data using the remaining clean data set. We demonstrate that CollaGAN produces the images with a higher visual quality compared to the existing competing approaches in various image imputation tasks.
6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine (RWJ 68354):  A Potent and Selective p38 Kinase Inhibitor (1998)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase InhibitorJames R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Bohumila Fahmy, Gilbert C. Olini, Janet E. Davis, J. Lee Pellegrino-Gensey, Peter H. Schafer, and John J. SiekierkaView Author Information The R.W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, New Jersey 08869 Cite this: J. Med. Chem. 1998, 41, 22, 4196–4198Publication Date (Web):October 7, 1998Publication History Received25 August 1998Published online7 October 1998Published inissue 1 October 1998https://doi.org/10.1021/jm980497bCopyright © 1998 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views555Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (44 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Assays,Inhibition,Inhibitors,Peptides and proteins,Rodent models Get e-Alerts
Generation of Immunosuppressive Mesenchymal Stem Cells in Allogeneic Human Serum (2007)

Mesenchymal stem cells (MSC) may be used to treat acute graft-versus-host disease and for tissue repair. In vitro expansion of MSC has been achieved in the presence of fetal calf serum (FCS). For safety and regulatory reasons, we explored if FCS could be replaced by human blood group AB serum. Proliferation and fold increase of MSC was higher in the presence of AB-serum, compared to FCS. Similar to cells generated in FCS media, MSC from AB-serum media were more than 95% positive for CD90, CD105 and human leukocyte antigen (HLA) class I, and negative for hematopoietic and endothelial markers CD14, CD31, CD34, CD45, and CD80. HLA class II expression was higher in MSC generated in AB-serum, but decreased with higher passage numbers. MSC generated in AB-serum suppressed lymphocyte proliferation in mixed lymphocyte cultures and after stimulation with phytohemagglutinin. MSC expanded in AB-serum and FCS have similar in vitro properties.
From single molecules to aggregates to gels in dilute solution: Self-organization of nanoscale rodlike molecules (2002)

A transition from a fluid to a constrained phase, in dilute solutions of a rodlike molecule, poly(2,5-dinonylparaphenylene ethynylene)s (PPE) in toluene has been studied, exploring the dynamics and the structure of the PPE molecules and the solvent in both phases. The transition is characterized by visual changes in the viscosity of the system and in its color, where a transparent liquid transforms into a yellow glassy phase. Nuclear magnetic resonance relaxation measurements indicated that significant restriction of motion of the solvent and of the polymeric molecule take place as the gel-like phase is formed. Small angle neutron scattering studies have shown that in the liquid phase, PPE forms molecular solutions where the molecules are fully extended. Upon transition into the constrained phase, aggregation of PPE molecules into large flat clusters occurs. When the aggregates are too large to freely move in the solution, a transition into a constrained phase takes place. The interaction between the highly conjugated PPE molecules and the solvent results in constraint of the motion of the solvent as well.