gebhart/patrepeval huggingface dataset:
MODÉLISATION ET CONTRÔLE D’UN CARREFOUR ISOLÉ À DEUX VOIES (2014)

Urban traffic is a complex system with heterogeneous nature. Vehicleflow that runs out along the lanes can be considered as a continuous flow. Itsdynamics will be modeled by continuous variables in time. The flow isinterrupted by the traffic lights sequences whose commutation cyclecorresponds to a discrete event system. Whole system is typically a hybriddynamic system. In this paper we propose to model this hybrid system by aD-elementary hybrid Petri Net where evolution of the continuous vehiclesflow (continuous marking of HPN), is interrupted by discrete eventssequence of intersection lights (discrete transitions of T-time PN). Thismodel will be translated in a hybrid automaton, where each vertexcorresponds to a continuous dynamic of vehicles flow. Time intervals oftransitions (guards) represent time intervals of traffic lights sequences. Inorder to guarantee a fluid traffic without congestion, we impose limits(specifications) on the continuous marking of each vertex of the automaton,and we recompute the new guards on transitions so that these Specificationsare always respected. Thus, we determine the traffic lights commutation planwhich ensures the waiting time optimization in intersection lights. As a realstudy case we have chosen an intersection traffic lights at the town center ofANNABA.
Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW) (2009)

Here we present an active patterning technique named "acoustic tweezers" that utilizes standing surface acoustic wave (SSAW) to manipulate and pattern cells and microparticles. This technique is capable of patterning cells and microparticles regardless of shape, size, charge or polarity. Its power intensity, approximately 5x10(5) times lower than that of optical tweezers, compares favorably with those of other active patterning methods. Flow cytometry studies have revealed it to be non-invasive. The aforementioned advantages, along with this technique's simple design and ability to be miniaturized, render the "acoustic tweezers" technique a promising tool for various applications in biology, chemistry, engineering, and materials science.
Update on Dialysis Economics in the UK (2011)

The burgeoning population of patients requiring renal replacement therapy contributes a disproportionate strain on National Health Service resources. Although renal transplantation is the preferred treatment modality for patients with established renal failure, achieving both clinical and financial advantages, limitations to organ donation and clinical comorbidities will leave a significant proportion of patients with established renal failure requiring expensive dialysis therapy in the form of either hemodialysis or peritoneal dialysis. An understanding of dialysis economics is essential for both healthcare providers and clinical leaders to establish clinically efficient and cost-effective treatment modalities that maximize service provision. In light of changes to the provision of healthcare funds in the form of "Payment by Results," it is imperative for UK renal units to adopt clinically effective and financially accountable dialysis programs. This article explores the role of dialysis economics and implications for UK renal replacement therapy programs.
Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer (2016)

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that targeting PARP reduces cell line and tumor growth in preclinical models. However, SCLC cell lines with PI3K/mTOR pathway activation were relatively less sensitive to PARP inhibition. In this study, we investigated the proteomic changes in PI3K/mTOR and other pathways that occur following PAPR inhibition and/or knockdown in vitro and in vivo. Using reverse-phase protein array, we found the proteins most significantly upregulated following treatment with the PARP inhibitors olaparib and rucaparib were in the PI3K/mTOR pathway (p-mTOR, p-AKT, and pS6) (p≤0.02). Furthermore, amongst the most significantly down-regulated proteins were LKB1 and its targets AMPK and TSC, which negatively regulate the PI3K pathway (p≤0.042). Following PARP knockdown in cell lines, phosphorylated mTOR, AKT and S6 were elevated and LKB1 signaling was diminished. Global ATP concentrations increased following PARP inhibition (p≤0.02) leading us to hypothesize that the observed increased PI3K/mTOR pathway activation following PARP inhibition results from decreased ATP usage and a subsequent decrease in stress response signaling via LKB1. Based on these results, we then investigated whether co-targeting with a PARP and PI3K inhibitor (BKM-120) would work better than either single agent alone. A majority of SCLC cell lines were sensitive to BKM-120 at clinically achievable doses, and cMYC expression was the strongest biomarker of response. At clinically achievable doses of talazoparib (the most potent PARP inhibitor in SCLC clinical testing) and BKM-120, an additive effect was observed in vitro. When tested in two SCLC animal models, a greater than additive interaction was seen (p≤0.008). The data presented here suggest that combining PARP and PI3K inhibitors enhances the effect of either agent alone in preclinical models of SCLC, warranting further investigation of such combinations in SCLC patients.
A novel active power filter for reactive power compensation and harmonic suppression (1993)

A new single-phase active power filter for reactive power compensation and harmonic suppression is proposed. Besides the general performance of other active power filters, it also has the feature that it can maintain the mains current as a sine-wave and correct the displacement power factor close to unity even when the mains voltage is distorted. A prototype of this active power filter is developed and tested under rectifier load to verify its performance. The test results show that the proposed scheme can compensate the reactive power and suppress harmonics of the nonlinear load effectively.
A Wideband 122GHz Cavity-Backed Dipole Antenna for Millimeter-Wave Radar Altimetry (2020)

A wideband and robust design of a cavity-backed dipole antenna at D-band for radar altimeter applications is presented. The proposed antenna is based on a planar multilayer arrangement using standard PCB technology which enables the seamless integration into a affordable millimeter wave sensor system. The antenna performance has been investigated by full wave simulations and validated by the fabrication and measurement of the antenna prototype. The experimental results of the realized antenna element show excellent agreement with the simulated values. The dipole antenna covers a 10dB impedance bandwidth from 119GHz to 126.6GHz and achieves a maximum gain of 6.9dBi. The measured 3D radiation patterns at various frequencies across the operational band are provided.
Cardiac disease in children and young adults with various lysosomal storage diseases: Comparison of echocardiographic and ECG changes among clinical groups (2013)

Echocardiographically detectable cardiovascular involvement in children with LSD is mostly confined to MPS and oLSD. Valve thickening in echo and a short PR interval in the ECG are the most frequent abnormalities. Routine repeat assessment is recommended in LSD. However, significant cardiac disease necessitating cardiac intervention is rare during a short follow-up.
Influence of the short-axis cine acquisition protocol on the cardiac function evaluation: A reproducibility study (2016)

Based on the results of the study cine mode short-axis acquisitions should be planned perpendicular to the septum in order to guarantee optimal RV and LV measurements.
Patient Motion in Thallium-201 Myocardial SPECT Imaging An Easily Identified Frequent Source of Artifactual Defect (1988)

Because Tl-201 SPECT requires that patients remain in an awkward position for a prolonged time, patient motion is a potentially serious source of artifactual defects on tomographic reconstructions. Thus, a simple method was developed for detection and correction of motion from SPECT images using a Co-57 point source placed on the lower anterior chest, an area remaining in the camera's field of view throughout imaging. In the absence of motion, this point source inscribes a straight line on planar summation of the 32 projections over 180 degrees. Movement is detected by deviation from this line. The number of pixels of motion is used to shift images so that the resultant images of the point source are linear. The method of motion detection and correction was tested in 48 consecutive patients undergoing Tl-201 SPECT. The corrected and uncorrected images were reconstructed and long and short axis tomographic cuts were quantitatively analyzed using circumferential profiles of maximal counts with comparison to the lower limits of normal. Motion was detected in eight of 48 patients (17%). The amount of motion was 2 pixels in three patients and 1 pixel in five patients. Quantitative defect extent was less after correction in seven of eight patients, with a mean decrease of 71% in patients with 2 pixel motion and 44% in patients with 1 pixel motion. This corresponded with a definite reduction in the size of the tomographic defect by visual analysis, and closer resemblance to quantitatively analyzed planar images performed either before or after tomography in the same patient.(ABSTRACT TRUNCATED AT 250 WORDS)
Buddhism and the Problem of Identity (Or: On the Virtue of Not Knowing Who You Are) (1988)

https://scholar.dominican.edu/books/1098/thumbnail.jpg
Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay (2018)

Interactions of chemically modified nucleic acid therapeutics with plasma proteins play an important role in facilitating distribution from the injection site to peripheral tissues by reducing renal clearance. Despite the importance of these interactions, analytical methods that can characterize binding constants with individual plasma proteins in a reliable and high throughput manner are not easily available. We developed a fluorescence polarization (FP) based assay and measured binding constants for the 25 most abundant human plasma proteins with phosphorothioate (PS) modified antisense oligonucleotides (ASOs). We evaluated the influence of sequence, sugar modifications, and PS content on ASO interactions with several abundant human plasma proteins and determined the effect of salt and pH on these interactions. PS ASOs were found to associate predominantly with albumin and histidine-rich glycoprotein (HRG) in mouse and human plasma by size-exclusion chromatography. In contrast, PS ASOs associate predominantly with HRG in monkey plasma because of higher concentrations of this protein in monkeys. Finally, plasma proteins capable of binding PS ASOs in human plasma were confirmed by employing affinity chromatography and proteomics. Our results indicate distinct differences in contributions from the PS backbone, nucleobase composition and oligonucleotide flexibility to protein binding.
Chromosomal instability and human cancer (2005)

Genetic instability is a defining feature of human cancer. The main type of genetic instability, chromosomal instability (CIN), enhances the rate of gross chromosomal changes during cell division. CIN is brought about by mutations of CIN genes, i.e. genes that are involved in maintaining the genomic integrity of the cell. A major question in cancer genetics is whether genetic instability is a cause and hence a driving force of tumorigenesis. A mathematical framework for studying the somatic evolution of cancer sheds light onto the causal relations between CIN and human cancer.
Water-Soluble Stimuli-Responsive Vesicles from Peptide-Based Diblock Copolymers (2002)

Polypeptide secondary structure controls the dimensions of aggregates formed from a polybutadiene-b-poly(L-glutamic acid) diblock copolymer after direct dissolution into water. The hydrodynamic radius (RH) of these aggregates (even at high NaCl concentrations) were found to correlate (see picture) with a transition from a compactly folded α-helical poly(L-glutamic acid) block at low pH to an extended random coil conformation at basic pH.
ChemInform Abstract: Automated Solid‐Phase Peptide Synthesis to Obtain Therapeutic Peptides (2015)

Abstract Review: 136 refs.
Legislative term limits in the United States (1999)

From 1990 to 1995 almost half of the American states adopted term limits for their congressional representatives and state legislatures. Although the US Supreme Court declared these laws unconstitutional as far as federal legislators are concerned, many states are proceeding to implement term limits for their own legislatures. This article examines the historical background to rotation in office, the political and constitutional issues involved, the term limits movement and its evolving strategies, congressional action on a proposed constitutional amendment and the impact on state legislatures. It concludes that the relative decline of the term limits movement since 1995 can be explained by a number of factors, including factionalism among its supporters and improving economic conditions in the country, but that it has made its own distinctive mark on American politics and its effects will be felt over the coming years.
Genaue Positionsbestimmung durch GPS mit differentieller Korrektur über Radio Data System (RDS) (1995)

Die Ortung von Fahrzeugen und mobilen Arbeitsgeraten uber GPS ist wesentlich eingeschrankt durch die Ungenauigkeit der angezeigten Positionsdaten, die Abweichungen von mehr als 100 m (RMS etwa 60 m) erreichen konnen. Mithilfe von Korrektursignalen, die uber die ortlichen Rundfunksendestationen ausgestrahlt und uber handelsubliche Radiogerate empfangen werden, kann ein einfaches und kostengunstiges differentielles GPS in Echtzeit mit hoher Genauigkeit (RMS etwa 2 m) realisiert werden.
Role of eosinophil-chemotactic C-C chemokines in cutaneous inflammation (1996)

In the dermal sites of atopic skin, eosinophil (Eo) granule protein or more rarely intact Eos represent a characteristic histological feature. We addressed the question of whether lesional scales of patients with various eosinophilic skin disorders contain Eo attractant and tried to characterize it biochemically. In scales of a patient with drug reaction, heparin-binding Eo attractants could be identified. High-performance liquid chromatographic analyses together with specific ELISA and Western blot analyses revealed identity with RANTES. No other heparin-binding Eo chemotaxin could be identified. HPLC analysis of pooled lesional scale extracts of patients with atopic dermatitis showed fractions containing only weak heparin-binding Eo-chemotactic activity, which, however, showed RANTES immunoreactivity. In experiments to elucidate the putative cellular origin of Eo-attracting chemokines in human skin we investigated supernatants of atopic skin we investigated supernatants of atopic skin-derived T lymphocytes as well as supernatants of stimulated dermal fibroblasts for Eo-chemotactic factors. Unexpectedly, we did not find any heparin-bound Eo attractants in supernatants of stimulated cultured atopic skin-derived T lymphocyte clones, whereas fibroblasts produced RANTES as well as granulocyte-macrophage colony-stimulating factor. Therefore, fibroblasts are likely source of eosinophil attractant cells, which could contribute to the Eo infiltrate. Selectivity of the infiltrate might come from selective induction of RANTES and/or induction of other as yet unidentified Eo-specific chemokines.
DC-Link Voltage Large Signal Stabilization and Transient Control Using a Virtual Capacitor (2010)

It is known that the interaction between poorly damped LC input filters with constant power loads leads to degradation of dynamic performance and instability of the system. This paper addresses the global stability study of an electrical system containing a DC power supply, an LC Filter and a constant power load. This latter is realized by a voltage source inverter supplying a Permanent Magnet Synchronous Motor (PMSM) or an Induction Motor (IM). To stabilize the system, the control structure is slightly modified to implement a nonlinear stabilization block which increases virtually the dc-link capacitance. The main idea consists in modifying the load power by adding a capacitive power component to the load power. This allows reducing the dc-link real capacitance value and size which is important in aerospace applications where engineers are looking for light and small systems. A drive consisted of an LC input filter connected to an inverter-PMSM designed for aircraft applications is treated as an illustrative example. Simulations and experimentations confirm the validity of the proposed approach.
Production of thyroid tumours in mice by demethylating agents (1992)

Previous studies on thyroid tumorigenesis in rodents have explored the role of oncogene mutation in tumour development. However, many mutagens are also known to decrease DNA methylation, another factor known to be important in the regulation of gene expression. We report the results of a small study to examine whether the demethylating agents 5-azacytidine and 5-aza-2-deoxycytidine could promote radiation- or goitrogen-induced tumorigenesis in the mouse, and whether they could potentiate the effect of a combined radiation and goitrogen regime. Three single doses of either 5-azacytidine or 5-aza-2-deoxycytidine increased the frequency of lesions in the goitrogen-treated animals; one of these lesions was a metastasising carcinoma. Thyroid carcinomas are very rare in mice in the absence of mutagen treatment, and metastasis is particularly unusual. There was no significant difference, at the dosages used, between the number of tumours induced by demethylating agents and those induced by a mutagen (radiation) in goitrogen-treated animals. Unlike goitrogens, demethylating agents did not promote radiation-induced tumorigenesis, and they did not produce any significant potentiation of the conventional regime of radiation and goitrogen at the dosages used. This study suggests that the role of non-genotoxic factors, such as agents affecting patterns of DNA methylation, warrants consideration in thyroid tumorigenesis.
Composition of Fecal Microbiota in Grazing and Feedlot Angus Beef Cattle (2021)

This study is to investigate the difference in bovine fecal microbiota between grazing and feedlot Angus cattle. Fecal samples were collected from six Angus cattle grazed on grassland and six Angus cattle fed on a feedlot. The fecal bacterial community was analyzed by high-throughput sequencing of 16S rRNA gene. Sequencing of the V3-V4 region totally produced 1,113,170 effective tages that were computationally clustered into 775 operational taxonomic units (OTUs). These 775 OTUs were taxonomically assigned to bacterial 12 phyla, 19 classes, 25 orders, 54 families, 141 genera, and 145 species. The dominant phyla were Firmicutes and Bacteroidetes. There was similar species richness between grazing and feedlot Angus beef, while higher species diversity was observed in feedlot Angus beef. The relative abundance of Firmicutes, Cyanobacteria, Elusimicrobia and Patescibacteria was significantly different between grazing and feedlot Angus beef (<i>p</i> < 0.05). At a genus level, five microbiotas were significantly different between the two groups and all belonged to the Firmicutes phylum. These significant differences in microbiota composition between grazing and feedlot Angus beef may have an impact on the meat quality of Angus beef.
Immunogenic Properties of PR8 Influenza Virus after Treatment with Acid Protease (1980)

Brief exposure of PR8 influenza virus at pH 4.5 to extracts of Aspergillus niger abolished the red cell agglutinating and infectious capacities of the virus without significantly decreasing its antigenicity or immunogenicity. The results of gel electrophoresis indicated that the HA1 portion of the viral hemagglutinin had been degraded by treatment of virus with Aspergillus extract. The immunogenicity in mice of virus that had been exposed to A. niger extract appeared to be very broad, since vaccination of mice with such material gave protection against challenge with strains of influenza A virus representing all major serotypes as well as one type B influenza virus.
Molybdenum In Stainless Steels (1977)

The effect of molybdenum in enhancing corrosion properties of stainless steels is reviewed. The resistance of different classes of Mo-containing stainless steels to localized and general corrosion in chloride and sulphate environments is summarized. The classes of steels referred to include 316-type austenitics, higher-alloy austenitics and the newer low-interstitial ferritic stainless steels. In addition to the presentation of experimental and field corrosion data, current ideas on the mechanism by which M0 enhances passivation are discussed. Résumé On rappellera l'influence du molybdène sur la corrosion des aciers inoxydables. On évaluera la résistance à la corrosion, localisée ou généralisée, de différentes classes d'aciers inoxydables au molybdène, en présence d'ions chlorures et d'ions sulfates. Les classes d'aciers étudiées inclueront les aciers austénitiques de type 316, les aciers austénitiques fortement alliés et les récents Miers inoxydables ferritiques à peu d'intersticiels. En plus de la présentation des données expérimentales dans le domaine de la corrosion, les diverses interprétations du mécanisme par lequel le molybdène favorise la passivation seront discutées.
Syntheses of Pyrrolo[2,3‐<i>d</i>]pyrimidine 2′,3′‐Dideoxyribonucleosides Related to 2′,3′‐Dideoxyadenosine and 2′,3′‐Dideoxyguanosine and Inhibitory Activity of 5′‐Triphosphates on HIV‐1 Reverse Transcriptase (1991)

Abstract The synthesis of 4‐chloropyrroIo[2,3‐ d ]pyrimidine and 2‐amino‐4‐chloropyrrolo[2,3‐ d ]pyrimidine α‐ D ‐ and β‐ D ‐2′,3′‐dideoxyribonucleosides 6a , b and 7a , b is described ( Scheme 1 ). Glycosylation of the pyrrolo[2,3‐ d ]‐pyrimidinyl anions of 1a , b with in situ prepared 2,3‐dideoxy‐α/β‐ D ‐ glycero ‐pentofuranosyl chloride ( 2 ) was regioselective but afforded anomeric mixtures of the 2′,3′‐dideoxyribonucleosides 3a / 4a and 3b / 4b , respectively. The glycosylation products were deprotected and subjected to nucleophilic displacement yielding various pyrrolo[2,3‐ d ]pyrimidine 2′,3′‐deoxyribonucleosides related to 2′,3′‐dideoxyadenosine and 2′,3′‐dideoxyguanosine. One‐pot phosphorylation gave the corresponding triphosphates. Some of them are strong inhibitors of HIV‐1 reverse transcriptase, similar to corresponding purine 2′,3′‐dideoxynucleotides, but exhibit a better selectivity index in comparison to DNA polymerases. According to that, the N( 7 ) of the purine moiety is not an essential binding position of ddATP or ddGTP at the active centre of HIV‐1 reverse transcriptase.
Metalearning for Context-aware Filtering (2017)

This work addresses the problem of selecting Tensor Factorization algorithms for the Context-aware Filtering recommendation task using a metalearning approach. The most important challenge of applying metalearning on new problems is the development of useful measures able to characterize the data, i.e. metafeatures. We propose an extensive and exhaustive set of metafeatures to characterize Context-aware Filtering recommendation task. These metafeatures take advantage of the tensor's hierarchical structure via slice operations. The algorithm selection task is addressed as a Label Ranking problem, which ranks the Tensor Factorization algorithms according to their expected performance, rather than simply selecting the algorithm that is expected to obtain the best performance. A comprehensive experimental work is conducted on both levels, baselevel and metalevel (Tensor Factorization and Label Ranking, respectively). The results show that the proposed metafeatures lead to metamodels that tend to rank Tensor Factorization algorithms accurately and that the selected algorithms present high recommendation performance.