gebhart/patrepeval huggingface dataset:
Evaluating Performance of Containerized IoT Services for Clustered Devices at the Network Edge (2017)

The constant and fast increase in the number of heterogeneous Internet of Things (IoT) devices that populate everyday life environments brings new challenges to the full exploitation of the computation, memory, sensing, and actuation resources associated to them. In this context, device virtualization solutions and platforms may definitely play a key role in enabling the desired tradeoff between flexibility and performance. This paper focuses on lightweight virtualization technologies for IoT devices, suitably thought to effectively deploy new integrated applications and to create a novel distributed and virtualized ecosystem. Two different frameworks for container-based IoT service provisioning are compared, the one based on a direct interaction between two cooperating devices and the other based on the presence of a manager supervising the operations between cooperating devices forming a cluster. In the latter case, accounting for the growing impetus to move intelligence toward the edge of the network, management features are implemented at the network access point to provide short latency responses. We also introduce the outcomes of a thorough performance evaluation campaign conducted via a real IoT testbed. The measurements, performed by accounting for the constraints of typical IoT nodes, shed light on the actual feasibility of container-based IoT frameworks.
Fluorescence modulation sensing of positively and negatively charged proteins on lipid bilayers (2013)

This study demonstrates the ability to monitor ligand-receptor interactions on supported lipid bilayers through the protonation or deprotonation of reporter dyes for both negatively and positively charged analytes over a range of pH and ionic strength conditions. Specifically, the sensitivity and pH-operating range of this technique can be optimized by modulating the sensing conditions which are employed.
Sn doped ZnO Thin Films Prepared by Pulsed Laser Deposition for Photovoltaic Applications (2014)

The objective of the present research work is to prepare various compositions of Sn doped ZnO thin films on a single crystal silicon (1 0 0) substrate via pulsed laser deposition technique, for investigation of valuable structural and optical properties. For this purpose, targets of pure and Sn-ZnO were prepared in the form of compressed, sintered and densified pellets by solid state reaction method. A KrF excimer laser ( =248 nm, τ=20 ns, El = 20 mJ and Φl=1 J/cm ) was employed to deposit various thin films on silicon substrate. Post deposition annealing of all the Sn-ZnO thin films was carried out at 300 C, and their structural and optical properties were investigated by X-ray diffraction (XRD) and Spectroscopic Ellipsometry (SE), respectively. It was observed from XRD results that ZnO (0 0 2) and SnO2 (2 1 0) were preferred planes orientations for all the Sn-ZnO thin films. The presence of SnO2 peak showed that SnO2 was epitaxialy included in ZnO matrix. The crystallite size of all the thin films was measured with the help of Scherrer formula and it was decreased with the increase of Sn concentration in ZnO. Spectroscopic ellipsometry analysis showed that the values of refractive index (n) and extinction coefficient (k) were increased and optical band gap of the thin films was decreased with addition of Sn contents in ZnO thin films. The modification in band gap energy could be attributed to the crystallites size of the thin film; the decrease in crystallite size decreased the band gap energy, which makes the thin films valuable for variety of photovoltaic applications.
Fuzzy rule-based analysis of spatio-temporal ATM usage data for fraud detection and prevention (2015)

We present a novel approach for detecting fraudulent behaviors from automated teller machine (ATM) usage data by analyzing geo-behavioral habits of the customers describe the use of a fuzzy rule-based system capable of classifying suspicious and non-suspicious transactions. We first compute the geographic entropies of ATM cardholders to form customer classes based on these entropies. ATM transactions are spatio-temporal by inclusion of location information. The transition data can be generated by using transaction data from the current location to the next one. Once, the transition data are generated, statistical outlier detection techniques can be utilized. On top of classical methods, we can easily use crisp unsupervised methods to detect outliers in the transition data. In addition, fuzzy C-Means algorithm can also easily be implemented to determine outliers. We analyze ATM usage dataset which contains around two years' worth of data, provided by a mid-size Turkish bank. We have shown that a significant bulk of ATM users does not leave the vicinity of their living places. We also present some insightful business rules that can be extracted from geo-tagged ATM transaction data by means of using a fuzzy rule-based system.
The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa (1984)

The structure of cyanoginosin-LA (previously referred to by us as toxin BE-4) is cyclo(-D-Ala-L-Leu-erythro-β-methyl-D-isoAsp-L-Ala-Adda-D-Glu-N-methyldehydroAla)(17a), where Adda refers to the novel β-amino acid residue of 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid (11). The connectivity of Adda is deduced from 1H- and 13C-n.m.r. data, but the stereochemistry at carbons 2,3,8, and 9 remains unknown. The residue sequence is derived from the mass spectra of cyclic and linear derivatives of the toxin. A new nomenclature for the related toxins of Microcystis aeruginosa is discussed.
Autologous Bone Marrow derived Mesenchymal Stem Cells (BM-MSCs) therapy for treatment of chronic limb wound in a bull. (2013)

Owing to the beneficial effect of Bone Marrow derived Mesenchymal Stem Cells therapy (BM-MSCs), a clinical application was attempted in a large sized chronic eight month old non-healing wound on right hind limb of a bull. The efficacy of technique was evaluated based on physiological, pathological and biochemical parameters. Photographic comparison and assessment, pain free walking distance, collagen tissue content, histopathological and histochemical analysis and tissue tensile strength evaluation confirming the clinical outcome. Application of BM-MSCs holds promising factor in healing of chronic non healing wound in bovines.
Sequential multiagent chemotherapy is not superior to high-dose cytarabine alone as postremission intensification therapy for acute myeloid leukemia in adults under 60 years of age: Cancer and Leukemia Group B Study 9222 (2004)

The Cancer and Leukemia Group B (CALGB) study 9222 tested the hypothesis that treatment intensification of acute myeloid leukemia (AML) in first remission with multiple chemotherapy agents is superior to high-dose cytarabine (HiDAC) alone. We enrolled 474 patients younger than 60 years old with untreated de novo AML. Daunorubicin and cytarabine resulted in complete remission (CR) in 342 patients (72%), and 309 of these patients were randomized to receive one of 2 different intensification regimens. The first regimen consisted of 3 courses of HiDAC. The second regimen consisted of one course of HiDAC, a second course with etoposide and cyclophosphamide, and a third course with diaziquone and mitoxantrone. After a median follow-up time of 8.3 years, the median survival for all randomized patients was 2.8 years (95% CI, 1.9-6.8 years). There was no difference in disease-free survival (DFS) between the 2 regimens (P = .66). The median DFS was 1.1 years (95% CI, 0.9-1.7 years) for patients receiving HiDAC and 1.0 year (95% CI, 0.9-1.3 years) for those receiving multiagent chemotherapy. Cytogenetics was the only pretreatment characteristic prognostic for DFS, but there was no evidence of a differential treatment effect within cytogenetic risk groups. Toxicity was greater with multiagent chemotherapy. These 2 postremission regimens produced similar outcomes.
Future therapeutic targets in osteoporosis (2009)

This review discusses potential future advances in drug therapy for osteoporosis including novel antiresorptive and anabolic agents that may become available in the coming years.
Bio-renewable fibers extracted from lignin/polylactide (PLA) blend (2012)

Due to the high cost and environment issues in the production of carbon fiber from polyacrylonitrile (PAN) and pitch, the use of low cost bio-renewable materials are of great interest as an alternative precursor. Lignin is a highly aromatic biopolymer, extracted as a byproduct of wood pulping and has been investigated as a suitable precursor for carbon fibers. In the present work, we have demonstrated the feasibility of spinning modified lignin/polylactide (PLA) blend into robust, fine lignin fibers. Chemical modification of raw lignin via butyration was investigated to enhance the miscibility of lignin with PLA due to the formation of ester functional groups in place of highly polar hydroxyl (-OH) groups. The butyrated structure was confirmed by nuclear magnetic resonance (NMR) spectroscopy and fourier transform infrared spectroscopy (FTIR). Modified lignin /PLA blends at different compositions were prepared by melt mixing in a twin-screw micro compounder. The influence of the blend composition on the compatibility between lignin and PLA was examined by differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). Thermogravimetric analysis (TGA) results of different blends revealed a systematic enhancement in the stability of the blends with the increase in PLA content from 0 to 50 wt .%. Lignin fibers were measured to possess modulus of about 500 to 2500 MPa, varied by B-lignin and PLA composition. Cylindrical morphology was observed in all lignin fibers. After carbonization, microvoids structure could be seen in ligninbased carbon fibers. Carbon fibers from B-lignin/PLA 75/25 maintained fibrous structure while carbon fibers from other ratios deformed during carbonization.
Tricorn protease (TRI) interacting factor 1 from <i>Thermoplasma acidophilum</i> is a proline iminopeptidase (1996)

Tricorn protease (TRI), a high molecular mass complex from the archaeon T. acidophilum, forms the core of a modular proteolytic system; upon interacting with low molecular mass factors intrinsic activities are enhanced and novel activities are generated. Here we characterize the first factor, F1, which turns out to be homologous with several bacterial proline iminopeptidases (PIPs). Surprisingly, it cleaves not only typical PIP substrates such as H-Pro-AMC, but a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. The pip gene encodes a 293 amino acid residue protein with a molecular mass of 33,487 Da. By means of site-directed mutagenesis we identified Ser105 and His271 as the active site nucleophile and proton donor, respectively. Experiments with inactive mutant PIPs indicate that the activities elicited by interacting with TRI are contributed by PIP.
Chemical Synthesis from Free Radicals Produced in Microwave Fields (1954)

Although much attention has been given to the physics of a microwave glow discharge, substantially less information is available regarding the chemical effects upon a gas undergoing such excitation. We have studied the chemical effects of a 2450-Mc/sec glow discharge on several gases and have made quantitative measurements on a few simple molecular systems, e.g., N2, H2, O2, air, CH4. A fundamental relationship has been found to exist between the yield in simple chemical systems and the controllable variables of electric field strength, contact time, and pressure. Analytical expressions for these relationships have been obtained.
Transcriptome profiling of sheep granulosa cells and oocytes during early follicular development obtained by Laser Capture Microdissection (2011)

The ovary is a complex mixture of different cell types. Distinct cell populations need therefore to be analyzed for a better understanding of their potential interactions. LCM and microarray analysis allowed us to identify novel gene expression patterns in follicular cells at different stages and in oocyte populations.
Magnetorheological finishing for imprinting continuous-phase plate structures onto optical surfaces (2004)

Magnetorheological finishing (MRF) techniques have been developed to manufacture continuous phase plates (CPPs) and custom phase corrective structures on polished fused silica surfaces. These phase structures are important for laser applications requiring precise manipulation and control of beam-shape, energy distribution, and wavefront profile. The MRF’s unique deterministic-sub-aperture polishing characteristics make it possible to imprint complex topographical information onto optical surfaces at spatial scale-lengths approaching 1 mm. In this study, we present the results of experiments and model calculations that explore imprinting two-dimensional sinusoidal structures. Results show how the MRF removal function impacts and limits imprint fidelity and what must be done to arrive at a high quality surface. We also present several examples of this imprinting technology for fabrication of phase correction plates and CPPs for use at high fluences.
Overview of the Hemostasis Research Program: Advances and Future Directions (2004)

The mission of the Combat Casualty Care Research Program of the US Army Medical Research and Material Command is to reduce the morbidity and mortality resulting from injuries on the battlefield through the development of new life-saving strategies, surgical techniques, biological and mechanical products, and the timely use of telemedicine technologies. One of the major areas of focus of the Combat Casualty Care Program is hemorrhage control. This article provides an overview of the Hemostasis Research Program and its accomplishments to date, and makes suggestions for areas of basic research in the future. The Hemostasis Research Program is based at the US Army Institute of Surgical Research (ISR) and includes collaborations with extramural research laboratories.
Investigation on the Frequency Range of Validity of Electroquasistatic RC Models for Semiconductor Substrate Coupling Modeling (2007)

Electroquasistatic analysis is currently the dominant approach for the modeling of semiconductor substrate noise coupling. The electroquasistatic (EQS) approximation is considered acceptable for frequencies such that the distances over which substrate interactions are considered are a small fraction of the wavelength. Yet, with clock bandwidths in state-of-the-art and future designs extending to multiple tens of gigahertz, it is necessary to accurately investigate and quantify the range of validity of the EQS approximation. This investigation is carried out in this paper by means of a rigorous electrodynamic model for the induced surface voltage due to an elementary dipole source in various types of commonly used semiconductor substrates for digital and radio-frequency integrated circuits. In addition to enabling a quantitative assessment of the frequency range of the validity of the electroquasistatic approximation and, hence, the RC models used commonly in computer-aided design tools for substrate noise coupling, the proposed electrodynamic model is used to investigate the prominence of inductive-like characteristics in noise propagation through the substrate. Through these investigations, it is demonstrated that the electrodynamic model used in this paper provides for a unified rigorous electromagnetic analysis of substrate noise coupling over the entire frequency bandwidth of interests to practical applications, from DC to multiple tens of gigahertz.
The integrin antagonist cilengitide increases the antitumor activity of temozolomide against malignant melanoma (2008)

Inhibitors of alphav integrins have been developed as anti-angiogenic agents for cancer therapy and, among them, cyclic RGD-containing pentapeptides, such as cilengitide, are the most commonly used integrin antagonists. In this study, cilengitide was tested in combination with the methylating agent temozolomide (TMZ), a well-tolerated anticancer drug with favourable pharmacokinetic properties currently used for the therapy of metastatic melanoma. To this end, the influence of cilengitide and TMZ on malignant melanoma growth and endothelial cell proliferation were investigated, using in vitro and in vivo models. The results indicated that cilengitide and TMZ exerted synergistic antiproliferative effects against melanoma and endothelial cells in vitro and induced a statistically significant reduction of in vivo melanoma growth with respect to treatment with the methylating agent only. In conclusion, this study proposes the use of cilengitide in combination with TMZ for the treatment of metastatic melanoma, thereby opening novel perspectives for the use of integrin inhibitors to enhance the efficacy of chemotherapy.
Fabrication of 3D nano-structures using reverse imprint lithography (2013)

In spite of the fact that the fabrication process of three-dimensional nano-structures is complicated and expensive, it can be applied to a range of devices to increase their efficiency and sensitivity. Simple and inexpensive fabrication of three-dimensional nano-structures is necessary. In this study, reverse imprint lithography (RIL) with UV-curable benzylmethacrylate, methacryloxypropyl terminated poly-dimethylsiloxane (M-PDMS) resin and ZnO-nano-particle-dispersed resin was used to fabricate three-dimensional nano-structures.UV-curable resins were placed between a silicon stamp and a PVA transfer template, followed by a UV curing process. Then, the silicon stamp was detached and a 2D pattern layer was transferred to the substrate using diluted UV-curable glue. Consequently, three-dimensional nano-structures were formed by stacking the two-dimensional nano-patterned layers. RIL was applied to a light-emitting diode (LED) to evaluate the optical effects of a nano-patterned layer. As a result, the light extraction of the patterned LED was increased by about 12% compared to an unpatterned LED.
Site Isolation in Phosphorescent Bichromophoric Block Copolymers Designed for White Electroluminescence (2009)

Organization of phosphorescent domains in seld-assembled block copolymers is demonstrated to yield dual emission for white electroluminescence. Our block- copolymer approach minimizes energy transfer between two colored species by site isolation through morphology control, allowing higher loading concentration of red emitters with improved device performance.
Synthesis and Biological Activity of Fluorinated Vitamin D (2010)

The active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1), has a wide range of biological activities, making its analogues promising therapeutic agents for the treatment of cancer, psoriasis and osteoporosis. In particular, the stability of the carbonfluorine bond to oxidation has aided in the development of fluorinated vitamin D analogues as catabolism inhibitors. The analogues were synthesized either by classical steroidal approaches or by convergent methods, depending on the sites of fluorination. The incorporation of fluorine has provided numerous advantages for studying the structurally flexible hormone 1α,25-dihydroxyvitamin D3 1, including helping to define its molecular mode of actions. Biological evaluation of the fluorinated analogues suggested that fluorine substitution would not only change the metabolism, but also have direct effects on the vitamin D receptor, resulting in compounds with unique activity profiles.
An Outer Membrane Vesicle Vaccine for Prevention of Serogroup A and W‐135 Meningococcal Disease in the African Meningitis Belt (2012)

The bacterium Neisseria meningitidis of serogroups A and W-135 has in the recent decade caused most of the cases of meningococcal meningitis in the African meningitis belt, and there is currently no efficient and affordable vaccine available demonstrated to protect against both these serogroups. Previously, deoxycholate-extracted outer membrane vesicle (OMV) vaccines against serogroup B meningococci have been shown to be safe and induce protection in humans in clonal outbreaks. The serogroup A and W-135 strains isolated from meningitis belt epidemics demonstrate strikingly limited variation in major surface-exposed protein structures. We have here investigated whether the OMV vaccine strategy also can be applied to prevent both serogroups A and W-135 meningococcal disease. A novel vaccine combining OMV extracted from recent African serogroup A and W-135 strains and adsorbed to aluminium hydroxide was developed and its antigenic characteristics and immunogenicity were studied in mice. The specificity of the antibody responses was analysed by immunoblotting and serum bactericidal activity (SBA) assays. Moreover, the bivalent A+W-135 vaccine was compared with monovalent A and W-135 OMV vaccines. The bivalent OMV vaccine was able to induce similar SBA titres as the monovalent A or W-135 OMV towards both serogroups. High SBA titres were also observed against a meningococcal serogroup C strain. These results show that subcapsular antigens may be of importance when developing broadly protective and affordable vaccines for the meningitis belt.
Screening for colorectal cancer. (2001)

Sidney Winawer and Ann Zauber state that no cardiopulmonary deaths occurred after the 13 000 colonoscopies in the Minnesota trial.[1][1] However, it is not known how many patients may have suffered a cardiovascular event related to colonoscopy that may have contributed to death at a later time. As
A Review of Solid Lubrication Technology (1971)

<div class="htmlview paragraph">The function of this paper is a review of the solid lubricant technology. Emphasis has been placed on lubricating solids, bonded films including binder materials, and developments in the self-lubricating materials including plastic and metal-bonded composites. Typical uses of solid lubricants are cited. Design guidelines for use of bonded films and self-lubricating composites are outlined.</div>
[Acid lipases and acid cholesterol esterases: Wolman's disease and cholesteryl ester storage disease]. (1988)

In the first part of the review are reported the properties of mammalian acid lipases and cholesterol esterases. Lysosomal acid lipase differs from the other acid or neutral lipases by its subcellular localization and a large substrate specificity on natural lipids, triglycerides and cholesteryl esters and on semi-synthetic or synthetic coloured or fluorescent substrates; the enzymatic activity of acid lipase depends on the presence of detergents and phospholipids and the structural properties are well known. In vivo, lysosomal acid lipase hydrolyses neutral lipids from exogenous origin (lipoprotein). The second part is an updated review on the diseases caused by hereditary acid lipase deficiency: Wolman's disease occurring in the first months of life and fatal before the age of one year and Cholesteryl Ester Storage Disease, a more benign form with normal lifespan. Both diseases are characterized by massive storage of neutral lipids. Molecular and metabolic pathways, new diagnostic tools used for the diagnosis and experimental cellular model systems are reviewed and discussed.
Device Identity with DICE and RIoT: Keys and Certificates (2017)

This draft specification describes a cryptographic device identity and attestation scheme based on the TLS protocol and X.509 client certificates.  The protocol and certificate formats can be implemented by any type of security processor, but are well suited to DICE+RIoT security architectures. Devices without hardware-based security can also implement the protocol in software, although the resultant identity and attestations will be of lower assurance.