gebhart/patrepeval huggingface dataset:
Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. (1993)

Neutrophil, or polymorphonuclear leukocyte (PMN), migration across intestinal epithelial barriers, such as occurs in many disease states, appears to result in modifications of epithelial barrier and ion transport functions (Nash, S., J. Stafford, and J. L. Madara. 1987. J. Clin. Invest. 80:1104-1113; Madara, J. L., C. A. Parkos, S. P. Colgan, R. J. MacLeod, S. Nash, J. B. Matthews, C. Delp, and W. I. Lencer. 1992. J. Clin. Invest. 89:1938-1944). Here we investigate the effects of epithelial exposure to IFN-gamma on PMN migration across cultured monolayers of the human intestinal epithelial cell line T84. Transepithelial migration of PMN was initially assessed in the apical-to-basolateral direction, since previous studies indicate general qualitative similarities between PMN migration in the apical-to-basolateral and in the basolateral-to-apical directions. In the apical-to-basolateral direction, epithelial exposure to IFN-gamma markedly upregulated transepithelial migration of PMN in a dose- and time-dependent fashion as measured by both electrical and myeloperoxidase assays. This IFN-gamma-elicited effect on transmigration was specifically due to a IFN-gamma effect on epithelial cells and was not secondary to IFN-gamma effects on epithelial tight junction permeability. Moreover, this IFN-gamma effect was dependent on epithelial protein synthesis, and involved a pathway in which CD11b/18, but not ICAM-1 or CD11a/18, appeared to play a crucial role in PMN-epithelial adhesion. IFN-gamma also substantially modified PMN transepithelial migration in the natural, basolateral-to-apical direction. The IFN-gamma effect on naturally directed transmigration was also specifically due to an IFN-gamma effect on epithelial cells, showed comparable time and dose dependency to that of oppositely directed migration, was CD11b/18 dependent, and required epithelial protein synthesis. Additionally, however, important qualitative differences existed in how IFN-gamma affected transmigration in the two directions. In contrast to apical-to-basolateral directed migration, IFN-gamma markedly downregulated transepithelial migration of PMN in the natural direction. This downregulation of PMN migration in the natural direction, however, was not due to failure of PMN to move across filters and into monolayers. Indeed, IFN-gamma exposure to epithelia increased the number of PMN which had moved into the basolateral space of the epithelium in naturally directed transmigration. These results represent the first detailed report of influences on PMN transepithelial migration by a cytokine, define conditions under which a qualitative difference in PMN transepithelial migration exists, and suggest that migration of PMN across epithelia in the natural direction may involve multiple steps which can be differentially regulated by cytokines.(ABSTRACT TRUNCATED AT 400 WORDS)
Automatic Secure Fingerprint Verification System Based on Fuzzy Vault Scheme (2006)

We construct an automatic secure fingerprint verification system based on the fuzzy vault scheme to address a major security hole currently existing in most biometric authentication systems. The construction of the fuzzy vault during the enrollment phase is automated by aligning the most reliable reference points between different templates, based on which the converted features are used to form the lock set. The size of the fuzzy vault, the degree of the underlying polynomial, as well as the number of templates needed for reaching the reliable reference point are investigated. This results in a high unlocking complexity for attackers with an acceptable unlocking accuracy for legal users.
Kinetics of epoxy resins formation from bisphenol‐A, tetrabromobisphenol‐A, and epichlorohydrin (1993)

Abstract The kinetics of formation of epoxy resins derived from bisphenol‐A, tetrabromobisphenol‐A, and epichlorohydrin under stoichiometric conditions was considered. The kinetics of reaction was studied by taking into account the consumption of the added alkali and epoxide group of epoxide oligomers. The obtained results satisfactorily explained that the reactivity of bisphenol‐A with epichlorohydrin is higher than that of tetrabromobisphenol‐A. The rate of dehydrochlorination of chlorohydrin ether in the presence of alkali and water is much higher than that of the rate of condensation of phenolic hydroxyl group with epichlorohydrin. The apparent reaction order of phenolic groups with epichlorohydrin and terminal epoxide groups in the oligomer are second order. The rate constants and reaction activation energy were determined. The results are discussed. © 1993 John Wiley & Sons, Inc.
Rate of increase of blue stained volume in mountain pine beetle killed lodgepole pine in northeastern Oregon, U.S.A. (1979)

Recently killed lodgepole pine (Pinuscontorta Dougl.) were examined to determine rate of spread of blue stain fungi introduced by mountain pine beetle (Dendroctonusponderosae Hopk.). Trees were felled, dissected at 2.5-m intervals, and photographed at each cross section to determine area of stain. Rate of spread is so rapid that salvaging mountain pine beetle killed lodgepole pine prior to severe staining is difficult.
Quantum communication technology (2010)

Quantum communication is built on a set of disruptive concepts and technologies. It is driven by fascinating physics and by promising applications. It requires a new mix of competencies, from telecom engineering to theoretical physics, from theoretical computer science to mechanical and electronic engineering. First applications have already found their way into niche markets, and university labs are working on futuristic quantum networks, but most of the surprises are still ahead of us. Quantum communication, and more generally quantum information science and technologies, are here to stay and will have a profound impact on the 21st century.
Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. (1993)

UCN-01 is a derivative of staurosporine, initially developed as a potentially selective inhibitor of the Ca(2+)- and phospholipid-dependent protein kinase C, but with the capacity to inhibit a number of tyrosine and serine/threonine kinases. UCN-01 inhibits the growth of 5 breast carcinoma cell lines with a 50% inhibitory concentration range of 30-100 nM during 6 days of continuous exposure. In MCF-7, MDA-MB453, and SK-BR-3 cells, UCN-01 is 5-fold more potent in growth inhibition than its diastereomer UCN-02, but the 2 compounds are equipotent in the inhibition of MDA-MB468 and H85787 cell growth. A differential sensitivity to a 24-h period of exposure to UCN-01 followed by drug removal and growth for 5 subsequent days was observed. The rank order for persistent inhibition of cells by UCN-01 was MCF-7, MDA-MB453 >> SK-BR-3 > H85787 > MDA-MB468. MCF-7 and MDA-MB453 cells did not resume proliferation within the 5 days after brief exposure to UCN-01. In contrast, MDA-MB468 and H85787 cells showed no net growth inhibition after a 24-h pulse of UCN-01, followed by 5 more days of growth in drug-free medium. In MDA-MB468 cells, 150 nM UCN-01 retards but does not prevent cell cycle progression through S phase, but the cells are clearly blocked from exit of G1 and entry into S. Progression through S phase is completely inhibited by 600 nM UCN-01. The development of a G1 to S block by UCN-01 in MDA-MB468 cells occurs in conjunction with inhibition of [32P]orthophosphate labeling and decreased phosphotyrosine mass of discrete cellular phosphoproteins.
Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis (2011)

We conclude that aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. These age-related differences may contribute to the blunted hypertrophic response seen after resistance-exercise training in older adults, and highlight the mTORC1 pathway as a key therapeutic target to prevent sarcopenia.
Concealed Integrity Monitoring for Wireless Sensor Networks (2011)

Nowadays, sensor networks are widely installed around the world. Typical sensors provide data for healthcare, energy management, environmental monitoring, etc. In the future sensors will become a part of critical infrastructures. In such a scenario the network operator has to monitor the integrity of the network devices, otherwise the trustworthiness of the whole system is questionable. The problem is that every integrity protocol needs a secure channel between the devices. Therefore, we will introduce a covert channel for hidden transportation of integrity monitoring messages. The covert channel enables us to hide integrity check messages embedded into regular traffic without giving potential attackers a hint on the used integrity protocol.
Electrically actuated, pressure-driven microfluidic pumps (2003)

In order to make the lab-on-a-chip concept a reality, it is desirable to have an integrated component capable of pumping fluids through microchannels. We have developed novel, electrically actuated micropumps and have integrated them with microfluidic systems. These devices utilize the build-up of electrolysis gases to achieve pressure-driven pumping, only require small voltages (approximately 10 V), and have approximate dimensions of 5 cm x 3 cm x 2 cm. Furthermore, these micropumps are composed of relatively inexpensive materials, and the reversible sealability of their poly(dimethylsiloxane) body to different microfluidic arrays enables repeated uses of the same pump. Under an applied potential of 10 V, three different micropumps had average flow rates of 8-13 microL min(-1) for water being pumped through five different 2 cm-long, 5500 microm(2) cross-sectional-area channels in poly(methyl methacrylate), in approximate agreement with predicted pump rates. We have also evaluated pump operation at the lower applied potential of 8 V and observed an average flow rate of 6.1 microL min(-1) for a pump-channel system. The current micropump design is capable of sustaining pumping pressures in the range of 300 kPa. The various advantages of these micropumps make them well suited for use in lab-on-a-chip analysis techniques.
Increased risk of ovarian cancer in integrin β3 Leu33Pro homozygotes (2005)

We previously demonstrated that integrin beta(3) Leu33Pro homozygotes have an increased risk of cancer, possibly most pronounced for ovarian cancer. We now test the latter hypothesis in case-control and prospective studies. We genotyped 463 Danish women with ovarian cancer, and 4291 women from the Danish general population. Calculation of odds ratios by conditional logistic regression was performed in the case-control study (n = 463 + 3543), and of ovarian cancer incidence, log-rank statistics and hazard ratios by Cox regression in the prospective study (n = 4291) with 9.5-year follow-up. In the case-control study matched for age and marital status, the odds ratio for ovarian cancer in homozygotes versus non-carriers was 1.6 (95% confidence interval: 1.0-2.6). In the prospective study with 28 incident ovarian cancers, non-carriers and homozygotes had incidences of 7 (4-11) and 30 (10-92) per 10 000 person-years (log-rank P = 0.02). The age-adjusted hazard ratio for ovarian cancer in homozygotes versus non-carriers was 3.9 (1.1-13). Risk of ovarian cancer did not differ between heterozygotes and non-carriers in either study. Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer.
Coplanar waveguide bandpass filter with hollow-T shaped transmission-line resonator for multiple spurious suppression (2013)

In this work, the coplanar waveguide (CPW) hollow-T shaped transmission-line resonator is proposed, which is achieved by introducing a series short-stub at the center of a quarter-wavelength transmission-line resonator. It can be used to implement CPW bandpass filter with additional transmission zeros for spurious suppression. Specifically, a 4th-order CPW bandpass filter centered at f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> = 2 GHz with multiple spurious suppression up to 5f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</inf> is demonstrated.
User-centric digital test architecture (2006)

This paper describes a combination of digital test instrument features that improve productivity and performance of digital tests by supporting their specification from the UUT's data sheet. Adaptive hardware features that allow this include: flexible timing, dynamic instrument reconfiguration, automatic handshaking, data compression, serial and asynchronous event handling, and hardware subroutines. These architectural features give the test engineer more flexibility, make test writing more efficient, and offer the possibility of more test coverage and analysis. The proposed modular design approach allows for more configurable and cost-efficient systems.
Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture (2016)

Nonribosomal peptide synthetases (NRPSs) produce a wide variety of peptide natural products. During synthesis, the multidomain NRPSs act as an assembly line, passing the growing product from one module to the next. Each module generally consists of an integrated peptidyl carrier protein, an amino acid-loading adenylation domain, and a condensation domain that catalyzes peptide bond formation. Some adenylation domains interact with small partner proteins called MbtH-like proteins (MLPs) that enhance solubility or activity. A structure of an MLP bound to an adenylation domain has been previously reported using a truncated adenylation domain, precluding any insight that might be derived from understanding the influence of the MLP on the intact adenylation domain or on the dynamics of the entire NRPS module. Here, we present the structures of the full-length NRPS EntF bound to the MLPs from Escherichia coli and Pseudomonas aeruginosa These new structures, along with biochemical and bioinformatics support, further elaborate the residues that define the MLP-adenylation domain interface. Additionally, the structures highlight the dynamic behavior of NRPS modules, including the module core formed by the adenylation and condensation domains as well as the orientation of the mobile thioesterase domain.
Affinity of Angiotensin I-Converting Enzyme (ACE) Inhibitors For N- and C-Binding Sites of Human ACE Is Different in Heart, Lung, Arteries, and Veins (1996)

Angiotensin-converting enzyme (ACE) has two enzymatically active domains: a C-domain in the carboxy terminal region and an N-domain in the amino terminal region. We based the pharmacologic characterization of these sites on the rat testis-lung model. In testis, only a truncate form of ACE is present (C-site), whereas both N- and C-sites are present in lung. In this model, captopril was shown to be N-selective and delaprilat to be C-selective. Ro 31-8472, a cilazapril derivative, and enalaprilat proved to be not site selective. We used these drugs to evaluate the affinity of C and N sites in various human tissues involved in the cardiovascular actions of ACE and used [125I]Ro31-8472 as ligand. The number and affinity of ACE binding sites were 17,680 +/- 2,345 fmol/mg protein (Kd = 0.32 +/- 0.04 nM) in lung, 560 +/- 65 (Kd = 0.36 +/- 0.05 nM) in heart, 237 +/- 51 (Kd = 0.37 +/- 0.06 nM) in coronary artery, 236 +/- 63 (Kd = 0.14 +/- 0.05 nM) in saphenous vein, and 603 +/- 121 (Kd = 0.50 +/- 0.06 nM) in mammary artery. The affinity (pKi) of captopril for the N sites ranged from 9.40 +/- 0.14 (lung) to 8.41 +/- 0.10 (coronary artery). The affinity for the C-site by delaprilat ranged from 9.97 +/- 0.15 (coronary artery) to 9.10 +/- 0.14 (mammary artery). Therefore, the affinity of C- and N-sites of ACE for ACE inhibitor (ACEI) drugs is different according to the organ involved. Because ACE is a glycosylated enzyme and glycosylation is organ dependent, we suggest that organ-specific glycosylation affects the binding characteristics of ACE inhibitors to N- or C-site of human tissular ACE.
Piezoelectric-Ceramic-Based Microgrippers in Micromanipulation (2010)

Microgrippers are widely applied in micromanipulation systems covering manufactural, biological and medical fields, and are especially important in microassembly process. There are several reasons. Firstly, as the size of microminiature parts is in millimetre or micron, the strength and stiffness compared to those of macro components is much smaller and thus microminiature parts are more easily damaged. Secondly, since geometric feature size for most of microminiature parts ranges between 0.01mm and 10mm, has not yet emerged a microgripper with which the scope to clipping all parts can be achieved. Thirdly, adhesion phenomena in microassembly process are a difficult problem that limits the development of microgrippers. At the beginning of the century, scholars have included the microgripper technology into research projects and made a lot of initial results. According to the driving force, microgrippers can be divided into piezoelectric-ceramic-based (Heyliger & Brooks, 1995), electrostatic-based (Majumder et al., 2001), electromagnetic-force-based (Quandt, 1997; Ashley, 1998), electric-based, vacuum, adhesive-material-based, shape-memory-alloy-based clampers, and so on. Li Q. and Li Y. (Li Q. & Li Y., 2004) summed up a detailed overview of microgripper profile and types.
Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha (2008)

Taken together, we demonstrate the power of integrating genomics data with expression data in deciphering tumor-related targets of CNI. Identification of 5p gene targets in CC denotes an important step towards biomarker development and forms a framework for testing as molecular therapeutic targets.
Analysis, evaluation, and comparison of algorithms for scheduling task graphs on parallel processors (2002)

In this paper, we survey algorithms that allocate a parallel program represented by an edge-weighted directed acyclic graph (DAG), also called a task graph or macro-dataflow graph, to a set of homogeneous processors, with the objective of minimizing the completion time. We analyze 21 such algorithms and classify them into four groups. The first group includes algorithms that schedule the DAG to a bounded number of processors directly. These algorithms are called the bounded number of processors (BNP) scheduling algorithms. The algorithms in the second group schedule the DAG to an unbounded number of clusters and are called the unbounded number of clusters (UNC) scheduling algorithms. The algorithms in the third group schedule the DAG using task duplication and are called the task duplication based (TDB) scheduling algorithms. The algorithms in the fourth group perform allocation and mapping on arbitrary processor network topologies. These algorithms are called the arbitrary processor network (APN) scheduling algorithms. The design philosophies and principles behind these algorithms are discussed, and the performance of all of the algorithms is evaluated and compared against each other on a unified basis by using various scheduling parameters.
Benefit From Exemestane As Extended Adjuvant Therapy After 5 Years of Adjuvant Tamoxifen: Intention-to-Treat Analysis of the National Surgical Adjuvant Breast and Bowel Project B-33 Trial (2008)

Despite premature closure and crossover to exemestane by a substantial proportion of patients, original exemestane assignment resulted in non-statistically significant improvement in DFS and in statistically significant improvement in RFS.
Requirements for motion-estimation search range in MPEG-2 coded video (1999)

The motion-estimation search range required for interframe encoding with the MPEG-2 video compression standard depends on a number of factors, including video content, video resolution, elapsed time between reference and predicted pictures, and, just as significantly, pragmatic considerations in implementing a cost-effective solution. In this paper we present a set of experimental results that provide a probabilistic characterization of the size of motion vectors for different types of video, from well-known standard test sequences to fast-paced sports sequences to action movie clips. We study the impact of search range on compression efficiency and video quality. Finally, and on the basis of these results, we conclude with recommendations for target search ranges suitable for high-quality compression of standard and high-definition video.
A novel nickel SALICIDE process technology for CMOS devices with sub-40 nm physical gate length (2003)

A novel nickel self-aligned silicide (SALICIDE) process technology has been developed for CMOS devices with physical gate length of sub-40 nm. The excess silicidation problem due to edge effect is effectively solved by using a low-temperature, in-situ formed Ni-rich silicide. With this new process, excess poly gate silicidation is prevented. Island diode leakage current and breakdown voltage are also improved.
A new family of MV terminations (1993)

By using high dielectric constant and nonlinear resistivity stress relief systems, the stress at cable ends can be controlled without using the traditional stress cones. High dielectric constant and nonlinear stress relief systems use material characteristics and not shape, which results in a range of possible constructions that can be interesting when cables are terminated in applications with limited space or when cables vary in size. A big advantage of this technology is that it can be 'built-in' into materials like mastic, rubbers, etc. This means modern installation techniques like cold-shrink and slip-on become possible.
Decade Counting Circuits (1946)

A direct-coupled pentode trigger pair, previously described, is made the basis of two simple ring-of-ten circuits for high speed counting. One of the circuits is especially suited for the counting of sharp pulses up to a frequency of 105 cycles per second. The other circuit is especially suited for frequency measurements on periodic currents of arbitrary wave form and of frequency from zero to above 105 cycles per second. The number of pulses or cycles counted by one ring-of-ten is indicated on the screen of a cathode-ray oscilloscope tube. Several of these ring-of-ten units, each with its cathode-ray tube, can be connected in cascade to make electronic counting with direct indication of the decimal figures possible.
Synthetic deoxyoligonucleotides as general probes for chloroplast transfer RNA genes (1982)

The utility of chemically synthesized deoxyoligonucleotides as hybridization probes for the detection of tRNA genes has been examined. Chloroplast tRNA genes were chosen for this study. Deoxyoligonucleotides complementary to highly conserved regions of chloroplast tRNA genes of both higher plants and Euglena gracilis were chemically synthesized. These synthetic probes have been used to detect tRNA genes by Southern hybridizations to restriction fragments of chloroplast DNAs. This new method of tRNA gene mapping and the oligonucleotides synthesized may be of general application to many chloroplast genomes. This is illustrated by the detection of known and unknown tRNA genes of Euglena gracilis and spinach, and unknown tRNA genes of maize and cucumber chloroplast DNAs. The precise locus and polarity of the Euglena gracilis chloroplast tRNAPhe gene has been determined. We also describe experiments which relate to the effects of the time of hybridization, the stringency of washing, and of base pair mismatches on the hybridization signal.