gebhart/patrepeval huggingface dataset:
Hybrid Inorganic-Organic Materials: Novel Poly(Propylene Oxide) Based Ceramers, Abrasion Resistant Sol-Gel Coatings for Metals, and Epoxy-Clay Nanocomposites. With an Additional Chapter On: Metallocene Catalyzed Linear Polyethylene (1999)

The sol-gel process has been employed to generate hybrid inorganic-organic network materials. Unique ceramers were prepared based on an alkoxysilane functionalized soft organic oligomer, poly(propylene oxide) (PPO), and tetramethoxysilane (TMOS). Despite the formation of covalent bonds between the inorganic and organic constituents, the resulting network materials were phase separated, composed of a silicate rich phase embedded in a matrix of the organic oligomer chains. The behavior of such materials was similar to elastomers containing a reinforcing filler. The study focused on the influence of initial oligomer molecular weight, functionality, and tetramethoxysilane, water, and acid catalyst content on the final structure, mechanical and thermal properties. The sol-gel approach has also been exploited to generate thin, transparent, abrasion resistant coatings for metal substrates. These systems were based on alkoxysilane functionazized diethylenetriamine (DETA) with TMOS, which generated hybrid networks with very high crosslink densities. These materials were applied with great success as abrasion resistant coatings to aluminum, copper, brass, and stainless steel. In another study, intercalated polymer-clay nanocomposites were prepared based on various epoxy networks montmorillonite clay. This work explored the influence of incorporated clay on the adhesive properties of the epoxies. The lap shear strength decreased with increasing clay content. This was due to a reduction in the toughness of the epoxy. Also, the delaminated (or exfoliated) nanocomposite structure could not be generated. Instead, all nanocomposite systems possessed an intercalated structure. The final project involved the characterization of a series of metallocene catalyzed linear polyethylenes, produced at Phillips Petroleum. Polyolefins synthesized with such new catalyst systems are becoming widely available. The influence of molecular weight and thermal treatment on the mechanical, rheological, and thermal behavior was probed. Although the behavior of this series of metallocene polyethylenes was not unlike that of traditionally catalyzed materials, this work is one of the first comprehensive studies of these new linear polyethylenes. The main distinction between the metallocene and traditional Ziegler-Natta catalyzed polyethylenes is the narrow molecular weight distributions produced by the former (for this series of materials, 2.3< Mw ï¿¼ Mn <3.6).
Structural and functional characterization of the human formyl peptide receptor ligand-binding region (1994)

The formyl peptide (N-formyl-1-methionyl-1-leucyl-1-phenylalanine [FMLP]) receptor is involved in the activation of neutrophils and their subsequent response to chemotactic N-formylated peptides. Recently, we found that the first extracellular loop closest to the N-terminal end of the FMLP receptor exhibited the strongest ligand binding compared with that shown by other extracellular regions. By constructing amino acid substitutional variants of this domain, we have determined that residues Arg-84 and Lys-85 on this loop play major roles in ligand-binding activity. Furthermore, random rearrangement of the residues of this receptor region demonstrated that the position of these charged amino acids did not affect their involvement in ligand binding, although their presence was essential for this binding to occur. We propose that the portion of the first N-terminal extracellular loop of the FMLP receptor containing residues Arg-84 and Lys-85 contributes significantly to the active site in ligand-receptor binding. We further propose that this binding is not dependent on defined structure but rather that these charged moieties may function as important "contacts" in receptor-ligand interactions.
Solving the Hamiltonian Cycle Problem using a Quantum Computer (2019)

We review existing quantum computational methods for solving the Hamiltonian cycle problem in different computational frameworks such as quantum circuits, quantum walks and adiabatic quantum computation. Then we present a QUBO (quadratic unconstrained binary optimization) formulation, which is suitable for the adiabatic quantum computation for a D-Wave architecture. Further, we derive a physical Hamiltonian from the QUBO formulation and discuss its adequateness in the adiabatic framework. Finally, we discuss the complexity of running the Hamiltonian cycle QUBO on a D-Wave quantum computer, and compare it with existing quantum computational methods.
Modern Supramolecular Chemistry (2008)

Cyclophanes Resorcinarene and calixarene synthesis Supramolecular Metallomacrocycles Supramolecular macrocycle synthesis by H-bonding assembly Supramolecular macrocycle synthesis by metal ion assembly Rotaxane and catenane synthesis Macrocyles via the Dynamic Covalent Bond Cucurbiturils Porphyrins Macrocyclic drugs (including macrocyclic Macrocycles by ring-closure metathesis Anion-binding macrocycles Macrocycles by acetylenic scaffolding
Modeling and quantification of cancer cell invasion through collagen type I matrices (2009)

Tumor invasion is the outcome of a complex interplay between cancer cells and the stromal environment. Considering the contribution of the stromal environment, we developed a membrane-free single-cell and spheroid based complementary model to study cancer invasion through native collagen type-I matrices. Cell morphology is preserved during the assays allowing real time monitoring of invasion-induced changes in cell structure and F-actin organization. Combining these models with computerized quantification permits the calculation of highly reproducible and operator-independent data. These assays are versatile in the use of fluorescent probes and have a flexible kinetic endpoint. Once the optimal experimental conditions are empirically determined, the collagen type-I invasion assays can be used for preclinical validation of small-molecule inhibitors targeting invasion. Initiation and monitoring of the single-cell and spheroid invasion model can be achieved in 8 h (over 3 days) and in 14 h (over 8 days) respectively.
Etoposide treatment suppresses atherosclerotic plaque development in cholesterol-fed rabbits. (1992)

To study the mechanisms by which monocytes/macrophages and smooth muscle cells contribute to atherosclerotic lesions, we studied atherosclerotic plaque formation in cholesterol-fed rabbits treated with etoposide, a drug that has been shown to have several effects that could interfere with the proposed interactions between these two cell types (M.W. Aarnoudes et al, Virchows Arch B 1984;47:211-216 and M. Rozencweig et al, Cancer 1977;40:334-342). Our results show that long-term etoposide treatment of New Zealand White rabbits maintained on a high-cholesterol diet decreases the extent of fatty streak formation in the aortic intima. Moreover, the plaques formed in the presence of etoposide are thinner and at least focally have less fibrous tissue and fewer smooth muscle cell-derived foam cells than do plaques in control rabbits. These effects are independent of the extent of the diet-induced hyperlipemia or an effect of etoposide on blood cell count and may be related to the inhibition of intimal cell proliferation by etoposide.
Low loss achieved in sol-gel based silica-on-siliconintegrated opticsusing borophosphosilicate glass (1995)

Polarisation-independent propagation losses of 0.2 dB/cm are reported for near-infrared silica-on-silicon channel guides formed using sol-gel borophosphosilicate glass deposited by repetitive spin coating and rapid thermal annealing. The low loss is ascribed to a reduction in process temperature, which has allowed a total glass thickness of 30 µm. The use of two dopants allows the glass viscosity to be adjusted independently of its refractive index, simplifying reflow and burial.
A Method of Producing Broad-Band Circular Polarization Employing an Anisotropic Dielectric (1957)

A procedure is described whereby it is possible to design circular polarizers for both waveguides and in window form to be used over a broad band of frequencies. The difference in phase constants for two mutually orthogonal E fields while propagating in an anisotropic dielectric is combined with the effect due to guide wall spacing to obtain a reasonably constant differential phase constant for the two fields over a broad frequency band. By properly choosing the length of the anisotropic dielectric in the direction of propagation, and orienting this dielectric properly with respect to an incident linearily-polarized wave, the transmitted wave is circularly polarized over a correspondingly broad band of frequencies.
Hardware Implementation of (63, 51) Bch Encoder and Decoder for Wban Using LFSR and BMA (2014)

Error Correcting Codes are required to have a reliable communication through a medium that has an unacceptable bit error rate and low signal to noise ratio. In IEEE 802.15.6 2.4GHz Wireless Body Area Network (WBAN), data gets corrupted during the transmission and reception due to noises and interferences. Ultra low power operation is crucial to prolong the life of implantable devices. Hence simple block codes like BCH (63, 51, In this paper, implementation of BCH (63, 51, t = 2) Encoder and Decoder using VHDL is discussed. The incoming 51 bits are encoded into 63 bit code word using (63, 51) BCH encoder. It can detect and correct up to 2 random errors. The design of an encoder is implemented using Linear Feed Back Shift Register (LFSR) for polynomial division and the decoder design is based on syndrome calculator, inversion-less Berlekamp-Massey algorithm (BMA) and Chien search algorithm. Synthesis and simulation were carried out using Xilinx ISE 14.2 and ModelSim 10.1c. The codes are implemented over Virtex 4 FPGA device and tested on DN8000K10PCIE Logic Emulation Board. To the best of our knowledge, it is the first time an implementation of (63, 51) BCH encoder and decoder carried out.
Water-based chlorination treatment of SBS rubber soles to improve their adhesion to waterborne polyurethane adhesives in the footwear industry (2005)

Abstract Solutions of trichloroisocyanuric acid (TCI) in different organic solvents are commonly employed in the footwear industry to improve the adhesion of SBS (styrene-butadiene-styrene) rubber soles to polyurethane adhesive. To avoid the use of organic solvents in the chlorinating solutions, several water-based chlorinating treatments were investigated in this study: (i) inorganic chlorine compounds (HCl-acidified sodium hypochlorite solution; free active chlorine (FAC) = 47.8 g/l); (ii) organic chlorine donors (aqueous solution of 3 wt% TCI/H2O, and ethanol solutions of 3 wt% HD (1,3-dichloro-5,5-dimethylhydantoine), or NCS (N-chlorosuccinimide); (iii) organic chlorine donor salts (aqueous solutions containing 3 wt% DCI (sodium dichloro isocyanurate), CB (chloramine B, N-chloro-sodium-phenylsulphenamide), or CT (chloramine T, N-chloro-sodium-p-toluenesulphenamide). The surface modifications produced by treatment of SBS rubber with the aqueous chlorinating agents were compared with those obtained by using the current solvent-based chlorinating treatment (3 wt% TCI/MEK). The FAC concentration and the chlorine stability in the solutions were determined by iodine titration, and the SBS rubber surface pH was determined with a flat pH probe. The surface modifications on the SBS rubber were analyzed by ATR-IR spectroscopy, XPS, contact-angle measurements and SEM. The adhesion properties were evaluated by T-peel strength tests on treated SBS rubber/waterborne polyurethane adhesive/roughened leather joints. The failed surfaces obtained after peel tests were analyzed by ATR-IR spectroscopy to precisely assess the locus of failure of the adhesive joints. The nature of the modifications produced on the SBS rubber surface depended on the chlorinating system used, the SBS rubber surface pH value, and the free active chlorine concentration of the chlorinating solution. The most effective chlorinating agents were TCI/H2O and HD/EtOH, but they were not stable over time due to quick chlorine evolution. Treatment with NaClO/HCl and DCI/H2O provided acceptable adhesive strength values although there was fast chlorine evolution in the NaClO/HCl solution; the free active chlorine concentration in the DCI/H2O solution was stable for at least 4 days after preparation. Finally, the treatment with NCS/EtOH, CB/H2O and CT/H2O did not chemically modify the SBS rubber surface, so the adhesion to polyurethane adhesive was not improved. Keywords: SBS RUBBERHALOGENATIONFOOTWEAR INDUSTRYSURFACE TREATMENTWATER-BASED CHLORINATION TREATMENTTRICHLOROISOCYANURIC ACIDCHLORAMINESODIUM HYPOCHLORITE
Removal of exhaust particulate from a Mercedes 300D diesel car. SAE Paper 770716 (1977)

The problem with diesel exhaust particulate is that it is too-small, too-light, and there is too-much of it. A series of experiments are described that investigate the potential of using an alumina-coated steel wool media, for agglomeration, and an advanced design inertia separator, for collection of the particulate from a 1975 Mercedes 300D diesel car. The goal of 50% reduction was realized when new. The effects on other emissions, performance, and noise were evaluated and durability defined.
Joint Power Allocation and Beamforming for Non-Orthogonal Multiple Access (NOMA) in 5G Millimeter Wave Communications (2018)

In this paper, we explore non-orthogonal multiple access (NOMA) in millimeter-wave (mm-wave) communications (mm-wave-NOMA). In particular, we consider a typical problem, i.e., maximization of the sum rate of a 2-user mm-wave-NOMA system. In this problem, we need to find the beamforming vector to steer towards the two users simultaneously subject to an analog beamforming structure, while allocating appropriate power to them. As the problem is non-convex and may not be converted to a convex problem with simple manipulations, we propose a suboptimal solution to this problem. The basic idea is to decompose the original joint beamforming and power allocation problem into two sub-problems which are relatively easy to solve: one is a power and beam gain allocation problem, and the other is a beamforming problem under a constant-modulus constraint. Extension of the proposed solution from 2-user mm-wave-NOMA to more-user mm-wave-NOMA is also discussed. Extensive performance evaluations are conducted to verify the rational of the proposed solution, and the results also show that the proposed sub-optimal solution achieves close-to-bound sum-rate performance, which is significantly better than that of time-division multiple access.
Vascular access in therapeutic apheresis: Update 2013 (2013)

This review addresses the types of vascular access available for patients who need therapeutic apheresis (TA). As in hemodialysis, vascular access for TA is chosen based on type of procedure prescribed, the patient's vascular anatomy, the acuity, frequency and duration of treatment, and the underlying disease state. The types of access available include peripheral vein cannulation, central venous catheters: including nontunneled and tunneled catheters, arterio-venous grafts and arterio-venous fistulas. Peripheral veins and central venous catheters are most frequently utilized for the acute administration of TA, and may be used over a period of weeks to months. Arterio-venous grafts and fistulas are not commonly used in TA procedures, but are an option in patients with an anticipated long course of TA, usually for a period of several months or years. The types and frequency of complications associated with various types of vascular access, including: access dysfunction and infections are reviewed, and strategies for their prevention and management are offered.
Net acid excretion during first week of life. (1981)

Metabolic acidosis occurs frequently in newborns. Net acid excretion (NAE) in 34 preterm and 12 term infants was measured during the first week of life. Twenty preterm infants received breast milk or formula; the remaining infants received total parenteral nutrition (TPN) -- synthetic amino acids or casein hydrolysate solution. NAE for breast milk vs formula fed infants was 5.4 +/- 0.4 and 7.8 +/- 0.6 muEq/min/m2 (mean +/- SEM). The corresponding values for the two TPN solutions in preterm infants were significantly higher at 12.5 +/- 1.4 and 19.4 +/- 3.5 muEq/min/m2. Term infants produced even greater amount of net acid, 20.6 +/- 2.9 and 35 +/- 3.7 muEq/min/m2 respectively for the two TPN solutions. Milk fed infants are less prone to acidosis because of base generated from milk consumption. Due to its inherent acidogenic effect, TPN solutions induce acidosis more readily. Infants receiving TPN are therefore required to generate a higher NAE rate to maintain acid-base homeostasis compared to milk fed infants.
Self recognition in allogeneic radiation bone marrow chimeras. A radiation- resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells (1981)

The specificity of the self-recognition repertoire in fully allogeneic (A {arrow} B), semiallogeneic (A {arrow} A x B and A x B {arrow} A), and double donor (A + B {arrow} A) radiation bone marrow chimeras was assessed by the ability of their spleen cells to generate in vitro primary plaque-forming cell (PFC) responses to trinitrophenyl- keyhole limpet hemocyanin. In contrast to spleen cells from semiallogeneic and double donor chimeras, intact spleen cells from fully allogeneic BI0 {arrow} B10.A and B10.A {arrow} B10 chimeras were not capable of generating responses to trinitrophenyl (TNP)-keyhole limpet hemocyanin. However, cultures containing a mixture of both B10 {arrow} B10.A and B10.A {arrow} B10 spleen cells did respond, demonstrating that all the cell populations required for the in vitro generation of T-dependent PFC responses were able to differentiate into functional competence in a fully allogeneic major histocompatibility complex (MHC) environment. The self recognition repertoire of T-helper cells from fully allogeneic A {arrow} B chimeras was determined to be specific for the recognition of host, not donor, MHC determinants in that they were able to collaborate with cells expressing only host MHC determinants but not with cells expressing only donor MHC determinants, even though the functional lymphocytes in these chimeras were shown to be of donor origin. Experiments utilizing double donor A + B {arrow} A chimeras further demonstrated that the ability of chimeric T cells to recognize allogeneic MHC determinants as self structures was a function of a radiation-resistant host element and not simply a consequence of the tolerization of T cell precursors to allogeneic MHC determinants, because strain A lymphocytes isolated from A + B {arrow} A chimeras were tolerant to both A and B MHC determinants but were restricted to the self recognition of syngeneic host type A MHC determinants. Finally, the Ir gene phenotype expressed by B10 {arrow} B10.A and B10.A {arrow} B10 chimeric lymphocytes was determined by their ability to function in the Ir gene controlled response to TNP-poly-L-(Tyr,Glu)-poly-D,L-Ala-poly- L-Lys [(T,G)-A--L]. The ability of lymphocytes to function in TNP-(T,G)-A--L responses was not determined by their genotype but rather paralleled the specificity of their self recognition repertoire for high responder (H-2 (b)) determinants. The possible degeneracy of the MHC-specific self recognition repertoire is discussed, and a model is proposed for Ir gene regulation in which expression of Ir gene function by lymphocytes is an antigen-nonspecific consequence of the specificity and cross-reactivity of their self recognition repertoire.
Low voltage current-mode filters: high performance and limitations (2002)

CMOS current-mode-filters based on a simple integrator operating in the ohmic region are presented. The highlights of this approach are their reduced power consumption and silicon area, high speed, programmability and low voltage supply. As an example, a 10.7 MHz biquadratic filter with a tunable Q.
Imaging brain activation induced by long trains of repetitive transcranial magnetic stimulation (1998)

Using positron emission tomography (PET), we measured the relative changes in regional cerebral metabolic rate of glucose (rCMRglc) during 2 Hz repetitive transcranial magnetic stimulation (rTMS) of the left sensorimotor cortex (SM1) and during imitation of rTMS-induced arm movements. Such stimulation caused an rCMRglc increase of about 8% within the SM1. The relative rCMRglc increase within SM1 was significantly greater in magnitude and larger in area during voluntary imitation of rTMS-induced arm movements. Moreover, the rostral part of the SMA was significantly more activated by voluntary movements than during rTMS. Combining rTMS and PET has the potential to visualize rTMS-related net brain activation, and may open up new possibilities for functional network analysis by comparing willed brain activation with electromagnetic brain activation.
<i>cis</i> -Acting Packaging Signals in the Influenza Virus PB1, PB2, and PA Genomic RNA Segments (2005)

The influenza A virus genome consists of eight negative-sense RNA segments. The cis-acting signals that allow these viral RNA segments (vRNAs) to be packaged into influenza virus particles have not been fully elucidated, although the 5' and 3' untranslated regions (UTRs) of each vRNA are known to be required. Efficient packaging of the NA, HA, and NS segments also requires coding sequences immediately adjacent to the UTRs, but it is not yet known whether the same is true of other vRNAs. By assaying packaging of genetically tagged vRNA reporters during plasmid-directed influenza virus assembly in cells, we have now mapped cis-acting sequences that are sufficient for packaging of the PA, PB1, and PB2 segments. We find that each involves portions of the distal coding regions. Efficient packaging of the PA or PB1 vRNAs requires at least 40 bases of 5' and 66 bases of 3' coding sequences, whereas packaging of the PB2 segment requires at least 80 bases of 5' coding region but is independent of coding sequences at the 3' end. Interestingly, artificial reporter vRNAs carrying mismatched ends (i.e., whose 5' and 3' ends are derived from different vRNA segments) were poorly packaged, implying that the two ends of any given vRNA may collaborate in forming specific structures to be recognized by the viral packaging machinery.