gebhart/patrepeval huggingface dataset:
Social isolation‐induced increase in the sensitivity of rats to the steroidogenic effect of ethanol (2003)

Social isolation of rats for 30 days immediately after weaning results in marked decreases in the cerebrocortical and plasma concentrations of pregnenolone, progesterone, 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG), and 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-TH DOC), as well as a moderate increase in the plasma concentration of corticosterone. This mildly stressful condition has now been shown to increase the sensitivity of rats to the effect of acute ethanol administration on the cerebrocortical and plasma concentrations of neuroactive steroids. The percentage increases in the brain and plasma concentrations of pregnenolone, progesterone, 3alpha,5alpha-TH PROG, and 3alpha,5alpha-TH DOC, apparent 20 min after a single intraperitoneal injection of ethanol (1 g/kg), were thus markedly greater in isolated rats than in group-housed animals. A subcutaneous injection of isoniazid (300 mg/kg) also induced greater percentage increases in the concentrations of these steroids in isolated rats than in group-housed animals. These results suggest that mild chronic stress, such as that induced by social isolation, enhances the steroidogenic effect of ethanol, a drug abused by humans under stress or affected by neuropsychiatric disorders. Social isolation also induced hyper-responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis, as was apparent after reduction of GABA-mediated inhibitory tone by isoniazid administration.
A phase 2 study of irinotecan, cisplatin, and simvastatin for untreated extensive‐disease small cell lung cancer (2010)

The current results indicated that simvastatin in combination with irinotecan and cisplatin did not improve the survival of patients with ED-SCLC. Although the subgroup analysis by smoking status was exploratory, the addition of simvastatin to irinotecan and cisplatin may improve the outcome of heavy smokers with ED-SCLC.
Dorrigocins: Novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. II. Isolation and elucidation of structures. (1994)

Two novel antifungal antibiotics, named dorrigocin A and B have been isolated from the fermentation broth and mycelium of Streptomyces platensis subsp. rosaceus. These closely related compounds were separated from one another by countercurrent chromatography on an Ito coil planet centrifuge. The structures of the dorrigocins were determined by NMR and IR spectroscopy and mass spectrometry. Each is a putative propionate-acetate derived straight chain fatty acid terminating in cycloheximide. The dorrigocins differ from one another only in their oxidation pattern.
From early wireless to Everest. (1998)

Medical information has been transmitted using wireless technologies for almost 80 years. A "wired wireless" electronic stethoscope was developed by the U.S. Army Signal Corps in the early 1920's, for potential use in ship-to-shore transmission of cardiac sounds. [Winters SR. Diagnosis by wireless. Scientific American June 11, 1921, p. 465] Today, wireless is used in a wide range of medical applications and at sites from transoceanic air flights to offshore oil platforms to Mt. Everest. 'Wireless LANs' are often used in medical environments. Typically, nurses and physicians in a hospital or clinic use hand-held "wireless thin client" pen computers that exchange patient information and images with the hospital server. Numerous companies, such as Fujitsu (article below) and Cruise Technologies (www.cruisetech.com) manufacture handheld pen-entry computers. One company, LXE, integrates radio-frequency (RF) enhanced hand-held computers specifically designed for production use within a wireless LAN (www.lxe.com). Other companies (Proxim, Symbol, and others) supply the wireless RF LAN infrastructure for the enterprise. Unfortunately, there have been problems with widespread deployment of wireless LANs. Perhaps the biggest impediment has been the lack of standards. Although an international standard (IEEE 802.11) was adopted in 1997, most wireless LAN products still are not compatible with the equipment of competing companies. A problem with the current standard for LAN adapters is that throughput is limited to 3 Mbps--compared to at least 10 Mbps, and often 100 Mbps, in a hard-wired Ethernet LAN. An II Mbps standard is due out in the next year or so, but it will be at least 2 years before standards-compliant products are available. This story profiles some of the ways that wireless is being used to overcome gaps in terrestrial and within-enterprise communication.
Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines (2013)

The molecular mechanisms involved in non‑small cell lung cancer tumourigenesis are largely unknown; however, recent studies have suggested that long non-coding RNAs (lncRNAs) are likely to play a role. In this study, we used public databases to identify an mRNA-like, candidate long non-coding RNA, GHSROS (GHSR opposite strand), transcribed from the antisense strand of the ghrelin receptor gene, growth hormone secretagogue receptor (GHSR). Quantitative real-time RT-PCR revealed higher expression of GHSROS in lung cancer tissue compared to adjacent, non-tumour lung tissue. In common with many long non-coding RNAs, GHSROS is 5' capped and 3' polyadenylated (mRNA-like), lacks an extensive open reading frame and harbours a transposable element. Engineered overexpression of GHSROS stimulated cell migration in the A549 and NCI-H1299 non-small cell lung cancer cell lines, but suppressed cell migration in the Beas-2B normal lung-derived bronchoepithelial cell line. This suggests that GHSROS function may be dependent on the oncogenic context. The identification of GHSROS, which is expressed in lung cancer and stimulates cell migration in lung cancer cell lines, contributes to the growing number of non-coding RNAs that play a role in the regulation of tumourigenesis and metastatic cancer progression.
Scanning Tunneling Microscopy of √3×√3-Bi Reconstruction on the Si(111) Surface (1993)

Bi-induced (√3×√3)R30° structures formed on the Si(111) surface are studied using scanning tunneling microscopy (STM) and LEED. Three distinct phases: monomer, trimer and honeycomb phases are identified for the first time by STM, depending on the Bi coverage, even though the √3×√3 symmetry has been always preserved in the LEED observation. At low coverages, Bi atoms are found to occupy the T 4 site. In this adsorption geometry, a monomer phase (α-phase) are formed stably up to an ideal coverage of 1/3 ML. In trimer symmetry (β-phase) at saturation coverage of 1 ML, the individual atoms of the Bi clusters are clearly resolved. Between these two coverages, however, a honeycomb-type √3×√3 reconstruction has been also found, by STM, to co-exist with the trimer phase. This result reveals a new coverage dependent reconstruction process involving the √3×√3 reconstruction of Si(111) surface.
Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy (2018)

To make nanomedicine potentially applicable in a clinical setting, several methods have been developed to synthesize pure nanodrugs (PNDs) without using any additional inert carriers. In this work, we report a novel green, low-cost, and scalable ice-template-assisted approach which shows several unique characteristics. First, the whole process only requires adding a drug solution into an ice template and subsequent melting (or freeze-drying), allowing easy industrial mass production with low capital investment. Second, the production yield is much higher than that of the traditional reprecipitation approach. The yield of Curcumin (Cur) PNDs is over two orders (∼140 times) magnitude higher than that obtained in a typical reprecipitation preparation. By adjusting simple processing parameters, PNDs with different sizes (∼20-200 nm) can be controllably obtained. Finally, the present approach can be easily applicable for a wide range of hydrophobic therapeutic drugs without any structural modification.
Dose-dependent Enhancement of In Vivo  GABAA–Benzodiazepine Receptor Binding by Isoflurane (2001)

Isoflurane exposure appeared to enhance receptor-specific 11C-flumazenil binding in a dose-dependent manner. The results suggest the possibility that a conformational change of the GABA(A)-R is involved in the mechanism of action of isoflurane in the living human brain.
MISIMO: A Multi-Input Single-Inductor Multi-Output Energy Harvesting Platform in 28-nm FDSOI for Powering Net-Zero-Energy Systems (2018)

This paper presents a power management unit that meets the need of small-form-factor net-zero energy systems by aggregating the maximum available power from three different energy sources while simultaneously regulating three output power rails over a wide dynamic load range, while also managing the charging and discharging of a battery, all in a single-stage single-inductor converter. The proposed architecture uses hysteresis control to regulate the voltage of each harvester at their respective maximum power points (MPPs) using pulse-frequency modulation (PFM) and adaptive inductor ON-time, all via a low-power event-driven controller. The converter, fabricated in 28-nm fully-depleted silicon-on-insulator (FDSOI), achieves a peak efficiency of 89% and supports an output power range from 1 μW to 60 mW with efficiency >75% at V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> =1 V and >69% at V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> = 0.6-0.9 V, all with a quiescent power of only 262 nW.
Targeting of proteins to mitochondria (2000)

A clear picture has emerged over the past years on how a 'classic' mitochondrial protein, like subunit IV of cytochrome c oxidase, might be targeted to mitochondria. The targeting and subsequent import process involves the commitment of the TOM (translocase in the outer mitochondrial membrane) receptor complex on the mitochondrial surface, a TIM (translocase in the inner mitochondrial membrane) translocation complex in the mitochondrial inner membrane, and assorted chaperones and processing enzymes within the organelle. Recent work suggests that while very many mitochondrial precursor proteins might follow this basic targeting pathway, a large number have further requirements if they are to be successfully imported. These include ribosome-associated factors and soluble factors in the cytosol, soluble factors in the mitochondrial intermembrane space, an additional TIM translocase in the inner membrane and a range of narrow specificity assembly factors in the inner membrane. This review is focused on the targeting of proteins up to the stage at which they enter the TOM complex in the outer membrane.
Federated Model Distillation with Noise-Free Differential Privacy (2020)

Conventional federated learning directly averages model weights, which is only possible for collaboration between models with homogeneous architectures. Sharing prediction instead of weight removes this obstacle and eliminates the risk of white-box inference attacks in conventional federated learning. However, the predictions from local models are sensitive and would leak training data privacy to the public. To address this issue, one naive approach is adding the differentially private random noise to the predictions, which however brings a substantial trade-off between privacy budget and model performance. In this paper, we propose a novel framework called FEDMD-NFDP, which applies a Noise-Free Differential Privacy (NFDP) mechanism into a federated model distillation framework. Our extensive experimental results on various datasets validate that FEDMD-NFDP can deliver not only comparable utility and communication efficiency but also provide a noise-free differential privacy guarantee. We also demonstrate the feasibility of our FEDMD-NFDP by considering both IID and non-IID setting, heterogeneous model architectures, and unlabelled public datasets from a different distribution.
Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. (1994)

We have generated mice with targeted disruptions of the src-like genes hck and fgr to assess the role of these kinases in myeloid cell development and function. Hematopoiesis appears to proceed normally in both hck-l- and fgr-l- animals, and in hck-l(-)-fgr-l- double homozygotes, but phagocytosis is impaired in hck-l- macrophages. Macrophages cultured from doubly homozygous, hck-l(-)-fgr-l- animals retain many other normal functional properties, suggesting that the deficiency of these kinases is complemented by other src family members. The specific activity of the Lyn protein kinase is increased in hck-l- macrophages, implying that Lyn may compensate for a deficiency in Hck. Doubly mutant animals, however, have a novel immunodeficiency characterized by an increased susceptibility to infection with Listeria monocytogenes, indicating that either hck or fgr is required to maintain a normal natural immune response. These data provide the first direct example of genetic interactions between src gene family members.
THE PALLADIUM-CHLORINE SYSTEM AT HIGH TEMPERATURE<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE PALLADIUM-CHLORINE SYSTEM AT HIGH TEMPERATURE1Wayne E. Bell, Ulrich Merten, and M. TagamiCite this: J. Phys. Chem. 1961, 65, 3, 510–517Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/j100821a028https://doi.org/10.1021/j100821a028research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
High frequency full bridge converter using multilayer coreless printed circuit board step up power transformer (2011)

In designing switch mode power supply (SMPS), the desirable feature is to have an efficient and compact design. The main idea is to increase the switching frequency and reduce the bulky magnetic parts of the converter. This leads to a compact size, less weight, reduced cost and increased power density of the converter. This paper presents a high frequency full bridge DC to DC converter, using a multilayer coreless printed circuit board (PCB) step-up power transformer. The converter was simulated and also implemented on the PCB. The pulse width modulated (PWM) signals were generated, using a microcontroller, to switch the Metal oxide semiconductor field effect transistor (MOSFET). The design of the converter is tested up to the power levels of 5 Watts with the switching frequency in 2 to 3MHz range. The energy efficiency of the converter is 74.86% at 2.4 MHz.
Human blood basophils display a unique phenotype including activation linked membrane structures (1987)

To evaluate the membrane marker profile of human basophils a panel of well-established monoclonal antibodies (MoAbs, n = 60) was used for a combined toluidine/immunofluorescence staining procedure. Myeloid-associated MoAbs (particularly MoAbs against the LFA-1 family (CD11, CDw18), MoAbs directed against lactosylceramide (CDw17), anti-glycoprotein (gp) 150 MoAbs MCS 2 and MY 7 (CDw13), anti-gp 67 MoAb MY 9, anti Fc gamma-receptor (mol wt 40 kd) MoAb CIKM5, anti-CR 1 MoAb E 11, and the antiglycolipid MoAb VIM-2) were reactive with basophils, indicating a close relationship to other mature myeloid cells. Under normal conditions, basophils surprisingly express at least three activation-linked structures not detectable on mature neutrophils, ie, the p45 structure defined by MoAbs OKT-10 and VIP-2b, the p24 structure identified by the CD9 MoAb BA-2, and the receptor for interleukin 2 (IL 2) recognized by three different MoAbs (anti-TAC, IL2RI, anti-IL 2). Moreover, under short-term culture conditions basophils both in mononuclear cell (MNC) suspension and as purified fractions display the HLA-DR and T4 antigens. The neutrophilic/eosinophilic structure 3-fucosyl-N-acetyllactosamine is expressed on basophils only after neuraminidase treatment. Basophils were not stained at all by CD 16 MoAbs directed against the Fc gamma-receptor (mol wt 50 to 70 kd) of neutrophils, by the MoAb 63D3 (CDw12) recognizing the monocyte/granulocyte-associated p 200 antigen, and by the CDw 14 antibodies (VIM-13, Mo 2) defining the monocyte-specific structure p 55. Enriched basophils freshly obtained from chronic granulocytic leukemia (CGL) patients yielded identical results in FACS analyses. In summary, these data indicate that basophils generate a unique combination of surface determinants and possibly represent an activated cell population.
<title>Fast-marching level-set methods for three-dimensional photolithography development</title> (1996)

The fast marching method, introduced by Sethian, is a numerical technique for solving the Eikonal equation, and results from combining upwind schemes for viscosity solutions of Hamilton-Jacobi equations, narrow band level set methods, and a fast min-heap algorithm. On a rectangular grid of N total points, the fast marching level set method computes the solution to the Eikonal equation from given initial data in O(N log N) steps. In a series of papers, we have applied this technique to a wide collection of problems, including construction of geodesics on surfaces, computer vision, and shape-from-shading. In this paper, we analyze the application of the fast marching method to photolithography development.
Laparoscopic Gastric Banding for Morbid Obesity (1999)

Morbid obesity is a serious disease that is responsible for several comorbid conditions. Body mass indices > 40 require surgical procedures if diet programs fail. Laparoscopic adjustable gastric banding (LAGB), a more recently introduced gastric restrictive procedure, was designed to be a minimally invasive and reversible operation. 184 patients (164 women, 20 men) with a mean body mass index of 47.8 kg/m2 (range 36-79) were operated on. All patients had been excessively overweight for > 5 years. Each patient was given general anesthesia, and an adjustable LAP-BAND was implanted laparoscopically. The pouch size was 15 ml in all cases; and 3-4 sutures were placed to prevent dislocation. The conversion rate was 0%. The median operating time was 65 min (range 45-190). The mortality was 0%. The mean hospital stay was 5 days (range 4-6). The mean excess weight loss was 16% in 4 weeks, 23% in 3 months, 31% in 6 months, 58% in 1 year, and 87% in 2 years. The patient satisfaction index was 97.6%. Once a surgeon has acquired the necessary laparoscopic surgical experience, LAGB is a feasible, safe, and simple procedure with excellent postoperative results. LAGB does not permanently modify the anatomy of the stomach and maintains the natural continuity of the alimentary tract, while at the same time ensuring a steady weight reduction in morbidly obese patients. The fact that the gastric band can be applied laparoscopically is a significant advantage in this group of high-risk patients, who have less pain, faster postoperative recovery, more rapid return to normal activities, fewer wound infections, fewer hernia problems, and better cosmetic results. The rate of postoperative complications is approximately 9%. In 1.1% of patients, erosion occurred, and in 2.2%, slippage of the band. The rate of port-related complications was 3.2%. Reoperations were necessary in 6.4% of the patients.
The Disabled Patient (2000)

The Disabled PatientJohn J. Smith1 and Leonard Berlin2Audio Available | Share
3.7 kV Vertical GaN PN Diodes (2014)

There is a great interest in wide band-gap semiconductor devices for power electronics application. In this letter, vertical GaN p-n diodes fabricated on bulk GaN substrates are discussed. The device layers are grown by MOCVD on low defect density (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ) bulk GaN substrates. The measured devices show breakdown voltages of 3.7 kV with an area differential specific on-resistance (Rsp) of 2.95 mΩ-cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2.</sup>
Zur Epitaxie von Galliumnitrid auf nichtstöchiometrischem Spinell im System GaCl/NH<sub>3</sub>/He (1975)

Abstract Kristallperfektion und Orientierungsbeziehungen von GaN‐Epitaxieschichten auf {111}‐und {100}‐orientierten Spinellsubstraten, hergestellt durch Reaktion von GaCl und NH 3 in He als Trägergas, wurden mit der RHEED‐Technik untersucht. Die gefundenen Orientierungsbeziehungen sind: equation image Die beste Kristallperfektion wird bei Züchtungstemperaturen zwischen 1000…︁1050°C erhalten sowie bei Wachstumsraten, die größer als 1 μm/min sind. Für schnelles Wachstum ist die Wachstumsrichtung 〈10 1 1〉 besser geeignet als die Richtung 〈0001〉.
Asymmetric Optical Connections for Improved Network Efficiency (2013)

Links in an IP network are unidirectional but currently are routed over bidirectional optical circuits with identical A→Z and Z→A capacities. Potentially there could be savings if the two directions of an optical circuit could be treated independently. In this study of possible savings, we have quantified the asymmetry of traffic on a current large IP backbone. A theoretical greenfield network with similarly asymmetric traffic is modeled, and it is shown that the use of unidirectional circuits to satisfy traffic demands provides significant equipment savings. We consider this study of the benefits of this approach to be a first step in deciding whether it makes economic sense to tackle the hurdles that would face such a major change in network design and operations.
Histopathology of the rheumatoid lesion (1984)

Histochemical and ultrastructural techniques were used to examine the cartilage-pannus junction of 49 rheumatoid joints. Whereas 24 showed relatively acellular, fibrous pannus tissue, 25 demonstrated "cellular" junctions with different cell types at sites of erosion. Macrophages and fibroblasts were commonly observed as majority cell types in most specimens, but others showed mast cells, polymorphonuclear leukocytes, dendritic, or plasma cells as the predominant cell type. Some showed local accumulations of different cell types at sites along each junction. Our findings show that the cellular composition at sites of cartilage erosion varies greatly and suggest that cells are subject to turnover and interchange.