gebhart/patrepeval huggingface dataset:
An Internet application for home automation (2002)

Describes an Internet application that allows local and remote monitoring and control of a home. The application adopts an object-oriented philosophy, in which every home automation device is represented by an object. This leads to an integrated view of the home, with a common look-and-feel across all the devices, while supporting various methods of actuation and sensing. The application runs on a PC with a Web server. The user interface is implemented through a standard browser using common HTML pages or Java applets. The interaction with the home control system(s) is done through specific hardware or standard PC interfaces such as the serial port or USB, or by LAN. The application offers a powerful way of controlling and programming the behavior of the home, using scripts. For the common user, a simpler version of a script - a scenario - may be used. A scenario consists of a set of devices in a particular state and can be activated directly by the user, by a time stimulus or by any event in the home.
Modeling Image Processing Systems with Homogeneous Parameterized Dataflow Graphs (2006)

We describe a new dataflow model called homogeneous parameterized dataflow (HPDF). This form of dynamic dataflow graph takes advantage of the fact that in a large number of image processing applications, data production and consumption rates, though dynamic, are equal across graph edges for any particular iteration, which leads to a homogeneous rate of actor execution, even though data production and consumption values are dynamic and vary across graph edges. We discuss existing dataflow models and formulate in detail the HPDF model. We develop examples of applications that are described naturally in terms of HPDF semantics and present experimental results that demonstrate the efficacy of the HPDF approach.
Immuno-oncology: the next generation of breakthrough therapies. Highlights from The Society for Medicines Research Symposium. Oxford, UK - June 21, 2019 (2019)

The approval of immune checkpoint inhibitors has revolutionized cancer therapy.Even so, there remains an urgent need to find treatments for patients that do not respond to or are not eligible to receive this class of drugs.Given this, many more innovative approaches are now being developed to redirect the immune system toward tumor cells, ranging from small molecules and novel biologics to cell therapies and gene therapy approaches.The aim of the 1-day meeting was to bring together renowned experts from academia and industry to discuss the latest immunotherapy advances and highlight how these discoveries form the basis of novel drugs that are designed to target key immunology pathways and transform the lives of cancer patients.This meeting was aimed at students and practicing professionals from academia and industry looking to gain an understanding of the pathological mechanisms at play within immune oncology and their targeting in discovery and development of novel immunotherapies.The symposium was held at St.
Design and Development of the 2002 UC Davis FutureTruck (2003)

<div class="htmlview paragraph">Yosemite is an advanced hybrid electric vehicle built on the Ford U152 Explorer platform. The University of California, Davis, FutureTruck team designed Yosemite to meet the following objectives:</div> <div class="htmlview paragraph"> <ol class="list nostyle"> <li class="list-item"><span class="li-label">1</span><div class="htmlview paragraph">Maximize vehicle energy efficiency</div></li> <li class="list-item"><span class="li-label">2</span><div class="htmlview paragraph">Minimize petroleum consumption</div></li> <li class="list-item"><span class="li-label">3</span><div class="htmlview paragraph">Reduce fuel cycle greenhouse gas emissions</div></li> <li class="list-item"><span class="li-label">4</span><div class="htmlview paragraph">Achieve California Super Ultra Low Emission Vehicle (SULEV) target</div></li> <li class="list-item"><span class="li-label">5</span><div class="htmlview paragraph">Deliver class-leading performance</div></li> </ol> </div> <div class="htmlview paragraph">The University of California, Davis FutureTruck team redesigned a 2002 Ford Explorer as a Hybrid Electric Vehicle to meet the following goals: reduce fuel cycle greenhouse gas emissions by 67%, double the fuel economy of a stock Explorer, meet California's Super Ultra Low Emissions Vehicle standard, and qualify for substantial Partial Zero Emissions Vehicle credits in California. <i>Yosemite</i> meets these goals with an efficient flexible fuel hybrid powertrain, improved component systems, and an advanced control system.</div> <div class="htmlview paragraph"><i>Yosemite</i> incorporates two independent powertrains to provide four-wheel drive and achieve stock towing capacity. The primary powertrain combines a 1.9L flexible fuel engine with a 75 kW brushless DC motor driving the rear wheels. This powertrain configuration is simple, compact, reliable, and allows flexibility in control strategy. The secondary powertrain is a 60 kW AC induction motor and reduction transaxle gearbox. Together, the two powertrains allow <i>Yosemite</i> to achieve high efficiency under normal operating conditions while matching stock vehicle performance. A 16.5 kWh nickel metal hydride traction battery pack powers the electric motors, providing up to 50 miles of all-electric range. <i>Yosemite's</i> superior fuel economy, low cost of operation, and performance, combined with advanced composites, telematics systems, and other consumer features make it a desirable and competitive vehicle in today's market.</div>
Field-Scale Evaluation of Aquifer and Wastewater Cleanup Using a Mobile Oxidation Pilot Plant (MOPP) : Phase I. Assembly and Preliminary Testing (1989)

Improper handling, storage and disposal of organic substances is responsible for a significant number of environmental contamination incidents in Illinois. Although many methods are available for the\ntreatment of organic contaminants in industrial wastewater and contaminated\nground water, most methods have drawbacks associated with them. Most treatment processes currently used for the cleanup of organic contaminants in ground water and industrial wastewater simply transfer\nthe contaminant between media, rather than destroy it. There is a need for a treatment process which can convert hazardous organic\nchemicals to harmless by-products, is universally applicable to various organic contaminants, and is practical for use on dilute waste streams. Another desirable feature would be the ability to skid- or\ntrailer-mount the process, to make it transportable for cleanup of contamination\nat remote locations. A group of treatment processes known as Advanced Oxidation\nProcesses (AOPs) rely on the generation of free-radicals in sufficient quantity to destroy organi c contaminants in water. Examples of such processes are ozonation in combination with ultraviolet radiation (UV),\nozonation in combination with hydrogen peroxide addition, and hydrogen peroxide in combination with UV. The effectiveness of these processes is due to the generation of hydroxyl radical, one of the most powerful\nknown solution-phase oxidants. Because of this, the advanced oxidation processes have the capability to convert organic contaminants entirely to innocuous substances such as carbon dioxide. Although the advanced oxidation processes have been extensively studied in the laboratory,\nvery few pilot or full-scale studies have been reported. Engineers have been understandably reluctant to specify AOPs in treatment process design, because reliable design, cost and operating information have\nnot been readily available. The purpose of this project was to assemble a mobile pilot plant which can be taken to field sites and operated to provide the information needed to facilitate the acceptance of these clean treatment processes by engineers and administrators. This report describes the\ndesign and capabilities of the assembled Mobile Oxidation Pilot Plant (MOPP), as well as some preliminary results from limited testing.
Preparation of long lengths of ultra-low-loss single-mode fibre (1979)

Single-mode m.c.v.d. fibres have been prepared in lengths of up to 10 km by incorporating easily sinterable cladding layers of both boron-phosphorus-and fluorine-phosphorus-doped silica. Minimum losses of 0.6 to 0.7 dB/km have been achieved in the wavelength range 1.1 to 1.7 μm.
A simple and correct shared-queue algorithm using compare-and-swap (1990)

The shared queue is a paradigm of concurrent processes. Because shared queues are central to many multiprocessor systems, their implementations require correctness and efficiency. We present a Compare-and-Swap shared-queue algorithm that permits concurrent access and is nondelaying, in that no processor need wait for an action by another processor. We present a verification method that analyzes the states of the shared data-structure. By drawing a graph that incorporates in a simple way the effects of multi-processor interleaving, one can quickly find errors in an algorithm or produce a proof of correctness. Since enqueue and dequeue operations may begin at any time, concurrent queue operations are represented by providing, in each state of the shared data-structure, one transition that initiates an enqueue operation and another transition for a dequeue operation. The method is a practical one that is applicable to a variety of algorithms that use shared data-structures.
Is there a future for global intelligent network standards? (2002)

The ITU-T has defined the global Intelligent Network (IN) standard IN Capability Set 1 (refined) (CS-1R) which is now being deployed worldwide. Global IN standardization has progressed in the last several years to produce the ITU-T IN CS-2 Recommendations which includes enhanced capabilities from CS-1R. But is there a future for evolution of global LN standards such as IN CS-3? Concerns have been raised regarding the scope, timeliness, and value of global IN standards. The advent of the IN Forum and the role of national and regional standards bodies also poses threats to global IN standards, in terms of duplication of effort and misalignment of approaches. The telecommunications industry, and IN in particular, is moving towards global service delivery, inter-domain interworking, and deregulation and increased competition. Is there a need for global IN standards in this new environment? This paper highlights key capabilities defined in IN CS-2 and indicates its relevance to the deployment of intelligent networks worldwide. The paper describes steps taken by the ITU-T and the IN subworking group to address concerns related to international standards timeliness and relevance. Finally, the paper discusses a variety of approaches in which the ITU-T IN sub-working group can achieve harmonization of regional interworking requirements and meet the needs of a dynamic industry.
Bad Smells and Refactoring Methods for GUI Test Scripts (2012)

Testing the GUI (Graphical User Interface) of a software application is typically accomplished by developing a GUI test script composed of sequences of events and assertions. A GUI test script is in a sense similar to the source code of a program, since events and assertions are like source-code statements, which are executed line by line. Therefore, like source code, a GUI test script may have bad smells, and refactoring is an effective technique that can eradicate bad smells, making the script better and easier to maintain. This paper studies the bad smells a GUI test script may have and the refactoring methods that can be applied to remove the bad smells. A total of 11 bad smells are identified and 16 refactoring methods are proposed. The refactoring methods have been implemented in a GUI testing tool, called GTT, to support the automatic refactoring of GUI test scripts.
Outdoor/indoor propagation modeling for wireless communications systems (2002)

The development of accurate propagation prediction models for outdoor/indoor communication environments is challenging and requires the development of innovative approaches to: (a) improve the accuracy of available models; (b) improve the computation efficiency; and (c) implement sufficiently general calculation procedures that would help in characterizing complicated and unique outdoor/indoor propagation features and environments. In this paper we describe a new propagation prediction model that addresses the above stated requirements. Specifically, the computational efficiency of the shooting-and-bouncing ray (SBR) was significantly improved by employing ray tracing techniques based on computer graphics approaches. The accuracy issue was addressed by employing a multi-grid FDTD method to calculate diffraction coefficients from unique and difficult to handle analytically indoor and outdoor structures. Additional improvement in accuracy was achieved by calculating reflection and transmission coefficients from walls of complex structures. Finally, the multi-grid FDTD method was used to characterize unique outdoor/indoor environments such as windows, doors, etc. The overall model was integrated, and propagation prediction results for typical outdoor/indoor communication environments are presented and compared with available data.
Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary<i>Tupaia</i>Hepatocytes (2005)

Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. The study of early steps during HCV infection has been hampered by the lack of suitable in vitro or in vivo models. Primary Tupaia hepatocytes (PTH) have been shown to be susceptible to HCV infection in vitro and in vivo. Human scavenger receptor class B type I (SR-BI) represents an HCV receptor candidate mediating the cellular binding of E2 glycoprotein to HepG2 hepatoma cells. However, the function of SR-BI for viral infection of hepatocytes is unknown. In this study, we used PTH to assess the functional role of SR-BI as a putative HCV receptor. Sequence analysis of cloned tupaia SR-BI revealed a high homology between tupaia and human SR-BI. Transfection of CHO cells with human or tupaia SR-BI but not mouse SR-BI cDNA resulted in cellular E2 binding, suggesting that E2-binding domains between human and tupaia SR-BI are highly conserved. Preincubation of PTH with anti-SR-BI antibodies resulted in marked inhibition of E2 or HCV-like particle binding. However, anti-SR-BI antibodies were not able to block HCV infection of PTH. In conclusion, our results demonstrate that SR-BI represents an important cell surface molecule for the binding of the HCV envelope to hepatocytes and suggest that other or additional cell surface molecules are required for the initiation of HCV infection. Furthermore, the structural and functional similarities between human and tupaia SR-BI indicate that PTH represent a useful model system to characterize the molecular interaction of the HCV envelope and SR-BI on primary hepatocytes.
Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors (2015)

CpG oligonucleotides (ODN) stimulate the innate immune system by triggering cells that express TLR9. The resulting response promotes tumor regression, an effect optimized by delivery of CpG ODN to the tumor site. This work examines the effect of instilling CpG ODN adsorbed onto polyketal microparticles (CpG-MP) into the lungs of mice with non-small cell lung cancer. Intrapulmonary delivery of CpG-MP improved ODN uptake and retention at the tumor site, thereby inducing a stronger Th1 response than systemically administered or unadsorbed CpG ODN. CpG-MP reversed the immunosuppression that characterized the tumor microenvironment by (i) decreasing the number of immunosuppressive Tregs and M2 macrophages while (ii) increasing the number of tumoricidal CD8(+) T cells and M1 macrophages. These effects promoted tumor regression and culminated in 82% permanent survival of mice with otherwise fatal Lewis lung cancer.
A baker's dozen magnitude approximations and their detection statistics (1976)

Thirteen linear approximations to the square root of the sum of the squares operation are examined and compared as to their peak error, average error, mean-squared error, and, most importantly, for digital radar signal processing the increase in SNR (over an exact linear detector) needed to maintain a specified PD and PFA.
Measuring the spring constant of atomic force microscope cantilevers: thermal fluctuations and other methods (2001)

Knowledge of the interaction forces between surfaces gained using an atomic force microscope (AFM) is crucial in a variety of industrial and scientific applications and necessitates a precise knowledge of the cantilever spring constant. Many methods have been devised to experimentally determine the spring constants of AFM cantilevers. The thermal fluctuation method is elegant but requires a theoretical model of the bending modes. For a rectangular cantilever, this model is available (Butt and Jaschke). Detailed thermal fluctuation measurements of a series of AFM cantilever beams have been performed in order to test the validity and accuracy of the recent theoretical models. The spring constant of rectangular cantilevers can also be determined easily with the method of Sader and White. We found very good agreement between the two methods. In the case of the V-shaped cantilever, we have shown that the thermal fluctuation method is a valid and accurate approach to the evaluation of the spring constant. A comparison between this method and those of Sader-Neumeister and of Ducker has been established. In some cases, we found disagreement between these two methods; the effect of non-conservation of material properties over all cantilevers from a single chip is qualitatively invoked.
Crystal Structure of dTDP-4-keto-6-deoxy-d-hexulose 3,5-Epimerase fromMethanobacterium thermoautotrophicum Complexed with dTDP (2000)

Deoxythymidine diphosphate (dTDP)-4-keto-6-deoxy-d-hexulose 3, 5-epimerase (RmlC) is involved in the biosynthesis of dTDP-l-rhamnose, which is an essential component of the bacterial cell wall. The crystal structure of RmlC from Methanobacterium thermoautotrophicum was determined in the presence and absence of dTDP, a substrate analogue. RmlC is a homodimer comprising a central jelly roll motif, which extends in two directions into longer beta-sheets. Binding of dTDP is stabilized by ionic interactions to the phosphate group and by a combination of ionic and hydrophobic interactions with the base. The active site, which is located in the center of the jelly roll, is formed by residues that are conserved in all known RmlC sequence homologues. The conservation of the active site residues suggests that the mechanism of action is also conserved and that the RmlC structure may be useful in guiding the design of antibacterial drugs.
Characterization of the murine heat‐stable antigen: An hematolymphoid differentiation antigen defined by the J11d, M1/69 and B2A2 antibodies (1990)

The heat-stable antigen (HSA) is a marker of hematopoietic differentiation in both the B and T cell lineages. The antigen is recognized by a series of monoclonal antibodies which includes J11d, M1/69 and B2A2, and in addition YBM5.10.4. We show here that all these antibodies recognize the same antigenic determinant which is expressed on a variably glycosylated membrane protein. Tunicamycin experiments show that the antigen is not carbohydrate in nature as it is expressed on two unglycosylated protein core molecules of molecular mass ca. 20 kDa and 17 kDa. Furthermore, the antigenic determinant appears to be lost following phosphatidylinositol-specific phospholipase C cleavage. Although the molecular mass of HSA appears to be heterogenous on cells of different lineages, these variations in size appear to be due primarily to differences in the extent of N-linked glycosylation, since both protein core molecules were found in all cell types investigated which express the antigen. These findings have important implications for the structure and function of this antigen and its role in hematopoietic development.
Validation of a Vibrating-Wire Viscometer:  Measurements in the Range of 0.5 to 135 mPa·s (2004)

The present article describes a novel vibrating-wire viscometer that has been shown to be able to measure viscosities up to 135 mPa·s, after calibration against water at 20 °C, to provide direct traceability to the primary reference for viscosity. For the purpose of validating the instrument, measurements of the viscosity of some selected fluids, including standard reference liquids with viscosity on the order of 100 mPa·s at 20 °C and 2,2,4-trimethylpentane with a viscosity of about 0.5 mPa·s at the same temperature, were performed. The results obtained show that the instrument is capable of performing viscosity measurements with an estimated overall uncertainty better than ±0.8% over the range of (0.5 to 135) mPa·s.
Equilibrium, kinetic, and footprinting studies of the Tus-Ter protein-DNA interaction. (1992)

Arrest of DNA replication in the terminus region of the Escherichia coli chromosome is mediated by protein-DNA complexes composed of the Tus protein and 23 base pair sequences generically called Ter sites. We have characterized the in vitro binding of purified Tus protein to a 37-base pair oligodeoxyribonucleotide containing the TerB sequence. The measured equilibrium binding constant (KD) for the chromosomal TerB site in KG buffer (50 mM Tris-Cl, 150 mM potassium glutamate, 25 degrees C, pH 7.5, 0.1 mM dithiothreitol, 0.1 mM EDTA, and 100 micrograms/ml bovine serum albumin) was 3.4 x 10(-13) M. Kinetic measurements in the same buffer revealed that the Tus-TerB complex was very stable, with a half-life of 550 min, a dissociation rate constant of 2.1 x 10(-5) s-1, and an association rate constant of 1.4 x 10(8) M-1 s-1. Similar measurements of Tus protein binding to the TerR2 site of the plasmid R6K showed an affinity 30-fold lower than the Tus-TerB interaction. This difference was due primarily to a more rapid dissociation of the Tus-TerR2 complex. Using standard chemical modification techniques, we also examined the DNA-protein contacts of the Tus-TerB interaction. Extensive contacts between the Tus protein and the TerB sequence were observed in the highly conserved 11 base-pair "core" sequence common to all identified Ter sites. In addition, protein-DNA contact sites were observed in the region of the Ter site where DNA replication is arrested. Projection of the footprinting data onto B-form DNA indicated that the majority of the alkylation interference and hydroxyl radical-protected sites were arranged on one face of the DNA helix. We also observed dimethyl sulfate protection of 2 guanine residues on the opposite side of the helix, suggesting that part of the Tus protein extends around the double helix. The distribution of contacts along the TerB sequence was consistent with the functional polarity of the Tus-Ter complex and suggested possible mechanisms for the impediment of protein translocation along DNA.
Mathematical properties of the jpeg2000 wavelet filters (2003)

The LeGall 5/3 and Daubechies 9/7 filters have risen to special prominence because they were selected for inclusion in the JPEG2000 standard. We determine their key mathematical features: Riesz bounds, order of approximation, and regularity (Hölder and Sobolev). We give approximation theoretic quantities such as the asymptotic constant for the L2 error and the angle between the analysis and synthesis spaces which characterizes the loss of performance with respect to an orthogonal projection. We also derive new asymptotic error formulae that exhibit bound constants that are proportional to the magnitude of the first nonvanishing moment of the wavelet. The Daubechies 9/7 stands out because it is very close to orthonormal, but this turns out to be slightly detrimental to its asymptotic performance when compared to other wavelets with four vanishing moments.