gebhart/patrepeval huggingface dataset:
Cancer-related neuropathic pain. (1998)

Neuropathic pain refers to syndromes that may be related to peripheral or central neural structure compression, infiltration, or damage. Cancer-related neuropathic pain results from compression or infiltration of nerves by the tumor, nerve trauma from operative procedures, or neuropathic pain related to cancer treatment. Management of neuropathic pain includes the use of opioids, antidepressants, anticonvulsants, local anesthetics, and other adjuvant medications. Intractable neuropathic pain may require the use of intraspinal delivery or anesthetic and neurosurgical procedures. The nurse practitioner plays an important role in the assessment and "trial and error" management of cancer-related neuropathic pain.
Protection of Killer Antiidiotypic Antibodies against Early Invasive Aspergillosis in a Murine Model of Allogeneic T-Cell-Depleted Bone Marrow Transplantation (2002)

Antiidiotypic monoclonal antibodies (MAbs) representing the internal image of a yeast killer toxin (KT) have therapeutic potential against several fungal infections. The efficacy of KT MAbs against Aspergillus fumigatus was investigated in a mouse model of T-cell-depleted allogeneic bone marrow transplantation (BMT) with invasive pulmonary aspergillosis. Mice were highly susceptible to infection at 3 days post-BMT, when profound neutropenia was observed both in the periphery and in the lungs. Treatment with KT MAbs protected the mice from infection, as judged by the long-term survival and decreased pathology associated with inhibition of fungal growth and hyphal development in the lungs. In vitro, similar to polymorphonuclear neutrophils, KT MAbs significantly inhibited the hyphal development and metabolic activity of germinated Aspergillus conidia. These results indicate that mimicking the action of neutrophils could be a strategy through which KT MAbs exert therapeutic efficacy in A. fumigatus infections.
One-step chromatographic immunoassay for qualitative determination of choriogonadotropin in urine (1990)

Journal Article One-step chromatographic immunoassay for qualitative determination of choriogonadotropin in urine Get access G Osikowicz, G Osikowicz Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar M Beggs, M Beggs Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar P Brookhart, P Brookhart Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar D Caplan, D Caplan Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar S Ching, S Ching Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar P Eck, P Eck Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar J Gordon, J Gordon Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar R Richerson, R Richerson Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar S Sampedro, S Sampedro Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar D Stimpson D Stimpson Abbott Laboratories, Abbott Park, IL 60064 Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 36, Issue 9, 1 September 1990, Page 1586, https://doi.org/10.1093/clinchem/36.9.1586a Published: 01 September 1990
Selective γ‐hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of γ‐hydroxybutyric acid (2003)

Two gamma-hydroxybutyric acid (GHB) analogues, trans-gamma-hydroxycrotonic acid (t-HCA) and gamma-(p-methoxybenzyl)-gamma-hydroxybutyric acid (NCS-435) displaced [3H]GHB from GHB receptors with the same affinity as GHB but, unlike GHB, failed to displace [3H]baclofen from GABAB receptors. The effect of the GHB analogues, GHB and baclofen, on G protein activity and hippocampal extracellular glutamate levels was compared. While GHB and baclofen stimulated 5'-O-(3-[35S]thiotriphospate) [35S]GTPgammaS binding both in cortex homogenate and cortical slices, t-HCA and NCS-435 were ineffective up to 1 mm concentration. GHB and baclofen effect was suppressed by the GABAB antagonist CGP 35348 but not by the GHB receptor antagonist NCS-382. Perfused into rat hippocampus, 500 nm and 1 mm GHB increased and decreased extracellular glutamate levels, respectively. GHB stimulation was suppressed by NCS-382, while GHB inhibition by CGP 35348. t-HCA and NCS-435 (0.1-1000 microm) locally perfused into hippocampus increased extracellular glutamate; this effect was inhibited by NCS-382 (10 microm) but not by CGP 35348 (500 microm). The results indicate that GHB-induced G protein activation and reduction of glutamate levels are GABAB-mediated effects, while the increase of glutamate levels is a GHB-mediated effect. Neither t-HCA nor NCS-435 reproduced GHB sedative/hypnotic effect in mice, confirming that this effect is GABAB-mediated. The GHB analogues constitute important tools for understanding the physiological role of endogenous GHB and its receptor.
The glycolytic enzyme phosphofructokinase-1 assembles into filaments (2017)

Despite abundant knowledge of the regulation and biochemistry of glycolytic enzymes, we have limited understanding on how they are spatially organized in the cell. Emerging evidence indicates that nonglycolytic metabolic enzymes regulating diverse pathways can assemble into polymers. We now show tetramer- and substrate-dependent filament assembly by phosphofructokinase-1 (PFK1), which is considered the "gatekeeper" of glycolysis because it catalyzes the step committing glucose to breakdown. Recombinant liver PFK1 (PFKL) isoform, but not platelet PFK1 (PFKP) or muscle PFK1 (PFKM) isoforms, assembles into filaments. Negative-stain electron micrographs reveal that filaments are apolar and made of stacked tetramers oriented with exposed catalytic sites positioned along the edge of the polymer. Electron micrographs and biochemical data with a PFKL/PFKP chimera indicate that the PFKL regulatory domain mediates filament assembly. Quantified live-cell imaging shows dynamic properties of localized PFKL puncta that are enriched at the plasma membrane. These findings reveal a new behavior of a key glycolytic enzyme with insights on spatial organization and isoform-specific glucose metabolism in cells.
Crack-free and conductive Si-doped AlN∕GaN distributed Bragg reflectors grown on 6H-SiC(0001) (2004)

We demonstrate Si-doped n-type AlN∕GaN distributed Bragg reflectors grown on 6H-SiC(0001). The structures are crack-free and have a stopband centered around 450nm with a full width at half maximum between 40 and 50nm. The maximum measured reflectance is ⩾99%. A comparison between Si-doped and undoped structures reveals no degradation of the reflectance due to the Si doping. Vertical conductance measurements at room temperature on the samples show an ohmic I–V behavior in the entire measurement range. The measured resistivity at 77K is only a factor of 2 larger than the resistivity measured at room temperature.
<b>Chemistry of Boranes. III.<sup>1</sup> The Infrared and Raman Spectra of B<sub>12</sub>H<sub>12</sub> - and Related Anions</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Boranes. III.1 The Infrared and Raman Spectra of B12H12 - and Related AnionsE. L. Muetterties, R. E. Merrifield, H. C. Miller, W. H. Knoth, and J. R. DowningCite this: J. Am. Chem. Soc. 1962, 84, 13, 2506–2508Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/ja00872a011https://doi.org/10.1021/ja00872a011research-articleACS PublicationsRequest reuse permissionsArticle Views914Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ASIP design for partially structured LDPC codes (2006)

A new class of partially structured LDPC codes is proposed and their performance evaluated. Part of the parity check matrix has a very regular structure that strongly simplifies implementation; a few randomly distributed ones, supported by a programmable ASIP (application specific instruction set processor), improve error correcting capabilities.
Securing MPLS Networks with Multi-path Routing (2007)

MPLS network architecture does not protect the confidentiality of data transmitted. This paper proposes a mechanism to enhance the security in MPLS networks by using multi-path routing combined with a modified (k, n) threshold secret sharing scheme. An IP packet entering MPLS ingress router can be partitioned into n shadow (share) packets, which are then assigned to maximally-node disjoint paths across the MPLS network. The egress router at the end will be able to reconstruct the original IP packet if it receives any k share packets. The attacker must therefore tap at least k paths to be able to reconstruct the original IP packet that is being transmitted, while receiving k-1 or less of share packets makes it hard or even impossible to reconstruct the original IP packet
Coherent detection of backscattered polarized laser with polarization diversity reception (2016)

Polarization information is widely used in laser communication as well as the detection of aerosol and clouds, etc. But the variation and degradation of the laser polarization state will seriously reduce the coherent efficiency, which will degrade the performance of coherent lidar. In this research, the method of polarization diversity reception (PDR) is mainly analysed to remove the decrease of coherent efficiency due to the polarization mismatch between the local-oscillator (LO) and backscattered polarized laser which acts as the echo signal, and the adoption of PDR can improve the efficiency and stability of coherent remote sensing lidar especially the coherent differential absorption lidar (CDIAL). To begin with, polarization variation of backscattered polarized laser is displayed by the Mie scattering theory, and based on Monte Carlo simulation, backscattering properties of horizontal polarized laser are analysed which shows that the average polarization angle of backscattered laser changes and tends to increase with the increase of particle size when laser is scattered by aerosols such as the fog particle. Then the effect of PDR is analysed, which shows that the PDR method can detect the echo power with high efficiency without the influence of polarization. Finally, to verify the effect of PDR, based on our experimental system of all-fiber CDIAL system, experiments are carried out which shows that PDR can reduce the amplitude fluctuation of intermediate-frequency (IF) signal; and fluctuation of extracted off line signal can be reduced from 8.78% to 0.25% with PDR. Besides, the adoption of PDR method can improve the resolution of CDIAL system.
Ion‐Size Effects in the Growth Sequences of Metal‐Ion‐Doped NobleGas Clusters (1997)

We have studied the stability and the structure of doped noble gas cluster ions of the type M + X n , (M=In, Al, Na, X=Ar, Kr, Xe) by systematically changing the composition M/X and observing changes in the magic number patterns appearing in the mass spectra. When the metal ion radius is comparable to the radius of the noble gas atom, the mass spectra show the familar icosahedral magic numbers n + 1=13,19,23,26,29,32, 46, 55,… In constrast, for metal ions with radii significantly smaller than the noble gas atoms, we observe a new series of magic numbers n + 9, 11, 17, 21,24, 26,… This series converts into the icosahedral one for larger clusters. Using a simple hard sphere packing model, we show that this new series of magic numbers is consistent with a cluster growth sequence which is based on a capped square antiprism (CSA) geometrical structure of the clusters.
Application of pixel segmentation to the low rate compression of complex SAR imagery (1998)

This paper describes a technique to identify pixels within a subregion ("chip") of a complex or detected SAR image which are to be losslessly compressed while the remainder of the image is subjected to a high compression ratio. This multi-modal compression is required for the intelligent low rate compression of SAR imagery, which addresses the problem of transmitting massive amounts of high resolution complex SAR data from a remote airborne sensor to a ground station for exploitation by an automatic target recognition (ATR) system, in a real time environment, over a narrow bandwidth. The ATR system results might then be presented to an image analyst who, using the contextual information from the SAR image, makes final target determination.
Ambipolar pentacene field-effect transistors with calcium source-drain electrodes (2004)

Field-effect transistors consisted of vacuum-sublimed polycrystalline pentacene films and calcium source-drain electrodes were prepared and device characteristics were evaluated in an oxygen-free condition. The field-effect transistor showed typical ambipolar characteristics and field-effect hole mobility of 4.5×10−4cm2/Vs and field-effect electron mobility of 2.7×10−5cm2∕Vs were estimated from saturation currents. Appearance of an electron enhancement mode in pentacene field-effect transistors was ascribed to the lowering of barrier for electron injection at source-drain electrodes. Effective elimination of electron traps using an oxygen-free condition was found to be another requirement for the observation of ambipolar behavior in pentacene.
Backscatter/Fundamental-Parameters Analysis of Unweighed Samples using Multi-Target, Multi-Crystal Regions of Interest from WDXRF and EDXRF (1991)

Abstract A method has been developed to simultaneously compute matrix corrections from a composite spectrum of multi-target energy-dispersive (EDXRF) and multicrystal wavelength—dispersive (WDXRF) x-ray fluorescence systems, A serial line installed between the WDXRF and EDXRF spectrometers via a PDF 11/34a computer allows acquired wavelength data to be digitally transformed into an energy spectrum. The low-energy x-ray information from the WDXRF unit is then coupled with the backscatter coherent/incoherent information from the EDXRF unit, enabling enhanced quantitative analysis for low-atomic-number (low-Z) elements. The peak resolution obtainable from the WDXRF spectra often removes the necessity for peak-overlap corrections. Backscatter intensities obtained from the EDXRF unit are used to provide information on total sample mass and to correct for matrix effects. The resulting backscatter fundamental-parameter (BFP) calculations generally provide an accurate analysis of samples without prior knowledge of the sample matrix. Such an approach is particularly useful for samples in which quantities of carbon, oxygen, and other low-Z constituents cannot be explicitly determined. Regions of interest (ROI) are created by the computer code “PREP” and processed by the BFP code "MSAP" an extension of the “SAP3” computer program for quantitative multielement analysis by energy-dispersive x-ray fluorescence,
Resonance phenomena in circuits with ultracapacitors (2013)

Resonance phenomena arising in circuits containing ultracapacitors are discussed in the paper. Ultracapacitor like a device based on the diffusion phenomenon force different dynamic compare to the dynamic of traditional capacitor which has huge influence for all good known relation in circuits. In the article the shift of the resonance frequency, due to the ultracapacitor presence in a circuit, is investigated. Also the difference between the resonance frequency and the frequency for a minimum circuit impedance is discussed. A problem of the ultracapacitor resonance frequency solved in this paper can play very important role in the design process of power electronic systems, for example in choosing a switching frequency.
Diamine-Free Lithiation−Trapping of <i>N</i>-Boc Heterocycles using <i>s</i>-BuLi in THF (2010)

A diamine-free protocol for the s-BuLi-mediated lithiation-trapping of N-Boc heterocycles has been developed. In the optimized procedure, lithiation is accomplished using s-BuLi in THF at -30 °C for only 5 or 10 min. Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered a range of functionalized pyrrolidines, imidazolidines, and piperazines in 43-83% yield.
An Analysis of Internet Data Update Behaviors (2006)

The growing application of caching in Internet applications have heretofore relied largely on qualitative observation and empirical data on the update behavior of Internet data in their design. While it is empirically known that the update behavior of such data is distinctly bimodal, much less is known about the details of these behaviors and the processes that drives them. A detailed study of the composition of modern Web sites that includes in-depth analyses of the changes made to the data of which those sites are composed offers a large potential benefit not only to Internet caching protocol developers but also to a broad cross-section of information technology professionals and researchers. The first results of just such a study are reported in this paper. A variety of popular Internet Web sites were selected and monitored for changes in both composition and content over a period of several weeks. Data collected in this study is then analyzed using traditional stochastic methods. The results of this investigation are summarized and suggested research directions conclude this article
Derivate des Methylendioxybenzols, XIX. Über die Darstellung von Cumaranonen‐(3) aus ω‐Diazo‐acetophenonen (1966)

Abstract Die optimalen Bildungsbedingungen für Cumaranone‐(3) aus o ‐Alkoxy‐ω‐diazo‐acetophenonen werden ermittelt. Das unterschiedliche reaktive Verhalten der Methylendioxy‐ und der Alkoxy‐Gruppen bei o ‐ständigen Diazocarbonylfunktionen wird untersucht. Die protonen‐katalysierte Synthese von 3.5‐Dioxo‐2.3.5.6‐tetrahydro‐benzo[1.2‐ b : 5.4‐ b ′]difuranen aus entsprechenden Bis‐diazoketonen wird beschrieben.
The Value of the Bone-marrow Biopsy in the Diagnosis of Hairy Cell Leukemia (1978)

Twenty-six patients with hairy cell leukemia have been evaluated clinically at Stanford University Medical Center and the M. D. Anderson Hospital and Tumor Institute since 1973. Only four patients had obvious leukemia and readily identifiable hairy cells in the peripheral blood. The remaining patients were pancytopenic, and hairy cells in peripheral blood were difficult to recognize. In 20 of the latter patients the marrow aspirates were unsuccessful or nondiagnostic. Bone-marrow biopsy was the primary method of diagnosis in 18 cases and proved the most reliable and pertinent diagnostic procedure in identifying this disorder. A well-defined water-clear rim of cytoplasm surrounding and separating the hairy cell nuclei was the main histologic feature, in contrast to the lack of visible cytoplasm and close appositon of lymphocytes in chronic lymphocytic leukemia or poorly differentiated lymphocytic lymphoma. The uniformity and blandness of the nuclei distinguished hairy cells in tissue sections from the cells of histiocytic lymphoma and acute myeloid leukemia. Awareness of the importance of the histologic appearance of the bone-marrow biopsy in hairy cell leukemia is essential in establishing an accurate diagnosis.
Automated spatiotemporal diffraction of ultrashort laser pulses (2003)

We exploit the close similarities between time-frequency and position-wave-vector correspondences to control the spatiotemporal diffraction pattern of ultrashort laser pulses. This approach permits novel, automated generation of sophisticated two-dimensional femtosecond waveforms. A two-dimensional space-time version of a Gerchberg-Saxton algorithm is used to iteratively determine the phase pattern in position-frequency space that produces a user-defined intensity profile in wave-vector-time space.
Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors (1996)

A series of novel P1/P1'-substituted cyclic urea-based HIV-1 protease inhibitors was prepared. Three different synthetic schemes were used to assemble these compounds. The first approach uses amino acid-based starting materials and was originally used to prepare DMP 323. The other two approaches use L-tartaric acid or L-mannitol as the starting material. The required four contiguous R,S,S,R centers of the cyclic urea scaffold are introduced using substrate control methodology. Each approach has specific advantages based on the desired P1/P1' substituent. Designing analogs based on the enzyme's natural substrates provided compounds with reduced activity. Attempts at exploiting hydrogen bond sites in the S1/S1' pocket, suggested by molecular modeling studies, were not fruitful. Several analogs had better binding affinity compared to our initial leads. Modulating the compound's physical properties led to a 10-fold improvement in translation resulting in better overall antiviral activity.
Efficient state space pruning in symbolic backward traversal (2002)

Most symbolic state space exploration techniques for finite state machines (FSMs) are exact and based on forward traversal, but limited to medium-size circuits. Approximate forward traversal deals with bigger circuits at the expense of exactness. Backward traversal focuses the search process on the property under scrutiny, but it also takes into account many unreachable states. For this reason, it works mainly on small circuits. This paper presents novel techniques that make exact symbolic backward traversal feasible also for large circuits. The key point is an efficient pruning of the search space, exploiting information coming from an approximate forward reachability analysis. Experimental evidence shows that, for the first time, the larger ISCAS'89 and MCNC circuits are symbolically manipulated in an exact way and the test patterns for them are generated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>