gebhart/patrepeval huggingface dataset:
Antiallergic effects of a novel compound, SWR-00151. (1997)

The effects of a newly synthesized compound, SWR-00151 (4-[2-[4-(1H-indol-3-yl)-1-piperidinyl)ethyl]-2(1H)-quinolinone), on experimental Type I allergic models were investigated. Results obtained were as follows: The compound (3 approximately 30 mg/kg, p.o.) dose-dependently inhibited 48-hr passive cutaneous anaphylaxis (PCA) in the rat. From the strong antagonism against the histamine-induced contraction of the isolated guinea pig ileum and the lack of suppressive effect on anaphylactic histamine release from rat peritoneal exudate cells, it is deduced that the compound's inhibitory action against PCA is due to antihistaminic action. Both gamma 1-rich serum- and IgE-rich serum-mediated experimental asthmas in the guinea pig were also considerably inhibited by a small dose (1 mg/kg, p.o.) of the compound. The inhibitory mechanism seems to be almost the same as that of the PCA because the compound did not show any effect on the experimental asthma in guinea pigs pretreated with H1- and H2-antihistaminics. In addition to that, it is well known that the model is largely mediated by anaphylactically released histamine. On the other hand, while ketotifen and oxatomide, which possess potent antihistaminic activity, modestly suppressed a rat experimental asthma SWR-00151 still demonstrated a substantial inhibitory activity, strongly suggesting that histamine does not play an important role in this asthma model. Serotonin was revealed to be partly responsible for the early phase of the reaction by the assessment with methysergide, an antiserotonergic, and SWR-00151 as well as oxatomide and ketotifen showed slight antagonism against serotonin in high concentrations (10(-6) and 10(-5) M) in vitro. When thromboxane (TX) B2 in the plasma was measured during the reaction, significant increased levels of the chemical mediator were found, which were obviously prevented by the treatment with SRW-00151. From these results, SWR-00151 is expected to be a drug effective for the treatment of asthma through mechanisms not only of antihistaminic action but also through inhibition of anaphylactic formation/release of other mediators like TXA2.
Self-tuning of MTPA current vector generation scheme in IPM synchronous motor drives (2007)

High performance PMSM drives require accurate selection of the current vector reference to be inputted to a suitable current control algorithm. This work implements a drive prototype with a current vector generation scheme which can be self-adjusted in "quasi real-time" to the actual maximum torque per amps locus. The model doesn't have to rely on computed or estimated motor parameters, but only on the analysis of additional signals superimposed on the driving voltages/currents, without affecting the overall drive performance.
Role of curcumin in idiopathic inflammatory orbital pseudotumours (2000)

The present report, describes for the first time the clinical efficacy of curcumin, the active constituent of rhizomes of Curcuma longa, in the treatment of patients suffering from idiopathic inflammatory orbital pseudotumours. Curcumin was administered orally at a dose of 375 mg/3 times/day orally for a period of 6-22 months in eight patients. They were followed up for a period of 2 years at 3 monthly intervals. Five patients completed the study, out of which four recovered completely and in one patient the swelling regressed completely but some limitation of movement persisted. No side effect was noted in any patient and there was no recurrence. It is suggested that curcumin could be used as a safe and effective drug in the treatment of idiopathic inflammatory orbital pseudotumours.
Biologically Active Acylglycerides from the Berries of Saw-Palmetto (<i>Serenoa repens</i>) (1997)

Brine shrimp lethality-directed fractionation of the 95% EtOH extract of the powdered, dried berries of Serenoa repens (Bart.) Small (saw-palmetto) (Palmae) led to the isolation of two monoacylglycerides, 1-monolaurin (1) and 1-monomyristin (2). Compounds 1 and 2 showed moderate biological activities in the brine shrimp lethality test and against renal (A-498) and pancreatic (PACA-2) human tumor cells; borderline cytotoxicity was exhibited against human prostatic (PC-3) cells. The fruits and extracts of saw-palmetto are taken orally as an herbal medicine to prevent prostatic hyperplasias.
DARPA's Explainable Artificial Intelligence Program (2019)

Dramatic success in machine learning has led to a new wave of AI applications (for example, transportation, security, medicine, finance, defense) that offer tremendous benefits but cannot explain their decisions and actions to human users. DARPA's explainable artificial intelligence (XAI) program endeavors to create AI systems whose learned models and decisions can be understood and appropriately trusted by end users. Realizing this goal requires methods for learning more explainable models, designing effective explanation interfaces, and understanding the psychologic requirements for effective explanations. The XAI developer teams are addressing the first two challenges by creating ML techniques and developing principles, strategies, and human‐computer interaction techniques for generating effective explanations. Another XAI team is addressing the third challenge by summarizing, extending, and applying psychologic theories of explanation to help the XAI evaluator define a suitable evaluation framework, which the developer teams will use to test their systems. The XAI teams completed the first of this 4‐year program in May 2018. In a series of ongoing evaluations, the developer teams are assessing how well their XAM systems' explanations improve user understanding, user trust, and user task performance.
Khimi Grammar and Vocabulary (1944)

Khami is one of the most important Sino-Tibetan languages because of the extensive data it presents regarding prefixes, preserved in so few groups of that linguistic family. The Khimi described here is a subdialect of the Southern dialect of the Khami language, Kukish group, Burmic division of Sino-Tibetan. Phonetically it differs from the more commonly recorded Southern dialect chiefly in the pronunciation of an original -a as -aw (as in English awe ).
Titanium Dioxide (TiO <sub>2</sub> ) Nanoparticles Induce JB6 Cell Apoptosis Through Activation of the Caspase-8/Bid and Mitochondrial Pathways (2009)

Titanium dioxide (TiO2), a commercially important material, is used in a wide variety of products. Although TiO2 is generally regarded as nontoxic, the cytotoxicity, pathogenicity, and carcinogenicity of TiO2 nanoparticles have been recently recognized. The present study investigated TiO2 nanoparticle-induced cell apoptosis and molecular mechanisms involved in this process in a mouse epidermal (JB6) cell line. Using the 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay, TiO2 nanoparticles were found to exhibit higher cytotoxicity than fine particles. YO-PRO-1 iodide (YP) staining demonstrated that both TiO2 nanoparticles and fine particles induced cell death through apoptosis. The signaling pathways involved in TiO2 particle-induced apoptosis were investigated. Western-blot analysis showed an activation of caspase-8, Bid, BAX, and caspase-3 and a decrease of Bcl-2 in JB6 cells treated with TiO2 particles. Time-dependent poly(ADP)ribose polymerase (PARP) cleavage induced by TiO2 nanoparticles was observed. TiO2 particles also induced cytochrome c release from mitochondria to cytosol. Further studies demonstrated that TiO2 nanoparticles induced significant changes in mitochondrial membrane permeability, suggesting the involvement of mitochondria in the apoptotic process. In conclusion, evidence indicated that TiO2 nanoparticles exhibit higher cytotoxicity and apoptotic induction compared to fine particles in JB6 cells. Caspase-8/Bid and mitochondrial signaling may play a major role in TiO2 nanoparticle-induced apoptosis involving the intrinsic mitochondrial pathway. Unraveling the complex mechanisms associated with these events may provide further insights into TiO2 nanoparticle-induced pathogenicity and potential to induce carcinogenicity.
Redox-active on-surface polymerization of single-site divalent cations from pure metals by a ketone-functionalized phenanthroline (2015)

Metallic iron, chromium, or platinum mixing with a ketone-functionalized phenanthroline ligand on a single crystal gold surface demonstrates redox activity to a well-defined oxidation state and assembly into thermally stable, one dimensional, polymeric chains. The diverging ligand geometry incorporates redox-active sub-units and bi-dentate binding sites. The gold surface provides a stable adsorption environment and directs growth of the polymeric chains, but is inert with regard to the redox chemistry. These systems are characterized by scanning tunnelling microscopy, non-contact atomic force microscopy, and X-ray photoelectron spectroscopy under ultra-high vacuum conditions. The relative propensity of the metals to interact with the ketone group is examined, and it is found that Fe and Cr more readily complex the ligand than Pt. The formation and stabilization of well-defined transition metal single-sites at surfaces may open new routes to achieve higher selectivity in heterogeneous catalysts.
Monocyclic and tricyclic analogs of quinolones: mechanism of action (1987)

The mode of action of Ro 13-5478 and Ro 14-9578, monocyclic and tricyclic quinolone analogs, respectively, was examined for Escherichia coli and Staphylococcus aureus. The compounds showed antibacterial activity and effects on cell morphology, replicative DNA biosynthesis, and gyrase-catalyzed DNA supercoiling that were comparable to those shown by nalidixic acid and by oxolinic acid compounds. The results suggest that their site of action is DNA gyrase and that a bicyclic quinolone nucleus is not essential for activity.
Undetectable on-line password guessing attacks (1995)

Several 3-party-based authentication protocols have been proposed, which are resistant to off-line password guessing attacks. We show that they are not resistant to a new type of attack called "undetectable on-line password guessing attack". The authentication server is not able to notice this kind of attack from the clients' (attacker's) requests, because they don't include enough information about the clients (or attacker). Either freshness or authenticity of these requests is not guaranteed. Thus the authentication server responses and leaks verifiable information for an attacker to verify his guess.
Polymer-Structure Dependence of Acid Generation in Chemically Amplified Extreme Ultraviolet Resists (2007)

For chemically amplified photoresists, the increase in the absorption of incident radiation by polymers leads to a decrease in the absorption by acid generators. Therefore, the absorption by polymers generally degrades resist sensitivities. However, this is not true for chemically amplified electron-beam (EB) resists because of the difference in the sensitization mechanisms of the acid generators. Whether the reaction mechanism of extreme-ultraviolet (EUV) resists is analogous to that of photoresists or EB resists is critical for material design. The difference in the reaction mechanisms characteristically appears in the polymer-structure dependence of the acid yield. In this study, we evaluated the relative dependence of the acid yield generated in polystyrene derivatives on the exposure to EUV. The dependence was similar to that of EB resists.
Volatile fluorinated alkoxides of the alkali metals (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVolatile fluorinated alkoxides of the alkali metalsRobert E. A. Dear, William B. Fox, R. J. Fredericks, Everett E. Gilbert, and Dale K. HugginsCite this: Inorg. Chem. 1970, 9, 11, 2590–2591Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/ic50093a044https://doi.org/10.1021/ic50093a044research-articleACS PublicationsRequest reuse permissionsArticle Views399Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<sup>1</sup>H NMR Structural Characterization of a Nonmitogenic, Vasodilatory, Ischemia-Protector and Neuromodulatory Acidic Fibroblast Growth Factor (2000)

A shortened genetically engineered form of acidic fibroblast growth factor (aFGF), that includes amino acids 28-154 of the full-length sequence (154 residues) plus Met in substitution of Leu27, does not induce cell division even though it is recognized by the cell membrane receptor, triggers the early mitogenic events, and retains the neuromodulatory, vasoactive, and cardio- and neuroprotective properties of the native full-length molecule. Taken together, these properties make this truncated aFGF a promising compound in the treatment of a wide assortment of neurological and cardiovascular pathologies where aFGF mitogenic activity is dispensable. Differences in biological activities between the shortened aFGF and the wild-type form have been attributed to lack of stability, and to the specific amino acid sequence missing at the N-terminus. Here we show that this shortened aFGF form has a three-dimensional structure even more stable than the wild-type protein at the mitogenic assay conditions; that this structure is similar to that of the wild type except at site 1 of interaction with the cell membrane receptor; that its lack of mitogenic activity cannot be attributed to the specific missing sequence; and that the vasodilatory activity of aFGF seems impaired by alterations of the three-dimensional structure of site 2 of interaction with the cell membrane receptor.
Intra-domain communication between the N-terminal and DNA-binding domains of the androgen receptor: modulation of androgen response element DNA binding (2005)

The androgen receptor (AR) is a ligand-activated transcription factor that recognises and binds to specific DNA response elements upon activation by the steroids testosterone or dihydrotestosterone. In vitro, two types of response element have been characterised - non-selective elements that bind the androgen, glucocorticoid and progesterone receptors, and androgen receptor-selective sequences. In the present study, the allosteric effects of DNA binding on the receptor amino-terminal domain (NTD) were studied. Binding to both types of DNA response element resulted in changes in the intrinsic fluorescence emission spectrum for four tryptophan residues within the AR-NTD and resulted in a more protease-resistant conformation. In binding experiments, it was observed that the presence of the AR-NTD reduced the affinity of receptor polypeptides for binding to both selective and non-selective DNA elements derived from the probasin, PEM and prostatin C3 genes respectively, without significantly altering the protein-base pair contacts. Taken together, these results highlight the role of intra-domain communications between the AR-NTD and the DNA binding domain in receptor structure and function.
Remarkably Stable Parallel-Stranded Oligonucleotides Containing 5-Methylisocytosine and Isoguanine (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTRemarkably Stable Parallel-Stranded Oligonucleotides Containing 5-Methylisocytosine and IsoguanineHiroshi Sugiyama, Shuji Ikeda, and Isao SaitoView Author Information Department of Synthetic Chemistry and Biological Chemistry Faculty of Engineering, Kyoto University Kyoto 606-01, Japan Cite this: J. Am. Chem. Soc. 1996, 118, 41, 9994–9995Publication Date (Web):October 16, 1996Publication History Received26 April 1996Published online16 October 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja961371bhttps://doi.org/10.1021/ja961371brapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views252Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Acid and base chemistry,Genetics,Melting,Oligomers,Stability Get e-Alerts
Pneumatic Otoscopy in Healthy Full-Term Infants (1987)

Pneumatic otoscopy was performed on 81 healthy full-term babies during the first 72 hours of life and at routine well-baby follow-up visits. Only 14 of 115 (12%) of the eardrums visualized during the first three days of life moved briskly to insufflation as compared with 29 of 65 (44%) and 50 of 71 (71%) by 3 weeks and 10 weeks of age, respectively. A pink color was noted in 38 of 115 (33%) and redness in five of 115 (4%) of the eardrums examined during the first 72 hours of life, whereas 64 of 71 (90%) of the tympanic membranes appeared gray by age 10 weeks. Tympanic membrane dullness, decreased light reflex, and diminished translucence occurred in greater than 90% of the infants during the first three days of life and declined to 26% or less by 4 months of age. The data suggest that limited mobility, changes in color, poor luster, and relative opacity of the tympanic membrane occur in healthy neonates and may reflect physiologic changes unique to the newborn period.
Lithography simulation-based full-chip design analyses (2006)

Today's design flows sign-off performance and power prior to application of resolution enhancement techniques (RETs). Together with process variations, RETs can lead to substantial difference between post-layout and on-silicon performance and power. Lithography simulation enables estimation of on-silicon feature sizes at different process conditions. However, current lithography simulation tools are completely shape-based and not connected to the design in any way. This prevents designers from estimating on-silicon performance and power and consequently most chips are designed for pessimistic worst-cases. In this paper we present a novel methodology that uses the result of lithography simulation for estimation of performance and power of a design using standard device- and chip-level analysis tools. The key challenge addressed by our methodology is to transform shapes generated by lithography simulation to a form that is acceptable by standard analysis tools such that electrical properties are preserved. Our approach is sufficiently fast to be run full-chip on all layers of a large design. We observe that while the difference in power and performance estimates at post-layout and on-silicon is small at ideal process conditions, it increases substantially at non-ideal process conditions. With our RET recipes, linewidths tend to decrease with defocus for most patterns. According to the proposed analyses of layouts litho-simulated at 100nm defocus, leakage increases by up to 68%, setup time improves by up to 14%, and dynamic power reduces by up to 2%. The key challenge addressed by our methodology is to transform shapes generated by lithography simulation to a form that is acceptable by standard analysis tools such that electrical properties are preserved. Our approach is sufficiently fast to be run full-chip on all layers of a large design. We observe that while the difference in power and performance estimates at post-layout and on-silicon is small at ideal process conditions, it increases substantially at non-ideal process conditions. With our RET recipes, linewidths tend to decrease with defocus for most patterns. According to the proposed analyses of layouts litho-simulated at 100nm defocus, leakage increases by up to 68%, setup time improves by up to 14%, and dynamic power reduces by up to 2%.
Sensing the environment for future driver assistance combining autonomous and cooperative appliances (2008)

Current driver assistance systems such as Adaptive Cruise Control (ACC) and in particular future assistance systems (e.g. Collision Warning) make high demands on reliability of detection and ranging methods for vehicles within their vicinity. Autonomous systems such as Radar which are already integrated into a multitude of vehicles meet these requirements to only a limited extent. As an alternative, cooperative systems for detection and ranging will be enabled by future Vehicle-2-Vehicle communication. But even if the technology is deployed in every vehicle, cooperative detection and ranging also has drawbacks regarding reliability due to positioning and transmission errors if it is applied in a standalone way. Thus, the solution presented in this paper is a hybrid approach combining autonomous and cooperative methods for detection and ranging within a common architecture. A particle filter is used for state estimation. The results are a higher detection effectiveness and a lower position error compared to using standalone autonomous or cooperative detection and ranging methods.
Image processing for compound documents (1995)

Until recently, a lot of document image processing (DIP) research has concentrated on the recognition of characters and shapes in document. Whilst the problems of text only based documents have largely been solved, there is a greater need to address the image processing problems posed by mixed-media or multimedia documents. Such documents, commonly referred to as compound documents containing a mixture of text, graphics, line-art, sound annotation, images etc. produce the problem of distinguishing the type of image processing required and in what sector of the document. This paper discusses the processes involved in transforming paper documents into electronic format and gives an example of an application involving the transformation of circuit diagrams to electronic CAD (ECAD) format.