gebhart/patrepeval huggingface dataset:
Über Umlagerung von Phenol‐allyläthern in <i>C</i>‐Allyl‐phenole (1912)

d e s A c e t e s s i g e s t e r s und verwandter Verbindungen hat sich ein bemerkenswerter Unterschied gezeigt, der zwischen den 0-Alkylderivaten mit den gewiihnlichen gesLttigten A l k g l e n (Methyl, Athyl, Propyl usw.) einerseits und den %All yl'derivaten andererseits besteht.Wahrend die ersteren so gut wie gar keine Neigung zeigen, sich in die isomeren C-Derivate umzulagern, tritt diese Neigung bei den 0 -A 11 y lderivaten i n stitrkstem Mn5e hervor.0-A l l y 1-acetessigester wird beim Destillieren uber etwas Salmiak fast vollstiindig in 0-Allyla c e t essiges t e r verwandelt : 0-Allyl-acetylaceton CH, .C(OCaH5):CH.CO .CHS lagert sich unter denselben Bedingungen glatt in C-All y 1-a c e t y l a c e t o n CHa .CO.CH (CaHj).CO .C& um.Ganz Entsprechendes wurde bei den Oxymethylenverbindungen beobachtet.Wiihrend beispielsweise beim O x y m e t h y l e n -c a m p h e r der 0-Metbylather CHj .C(OG Ho) : CH.COa CIHs -+ CH3.CO .CH(CgH5).COa Ca Hs;
Dymalloy: A composite substrate for high power density electronic components (1995)

High power density electronic components such as fast microprocessors and power semiconductors must operate below the maximum rated device junction temperature to ensure reliability. function temperatures are determined by the amount of heat generated and the thermal resistance from junction to the ambient thermal environment. Two of the Largest contributions to this thermal resistance are the die attach interface and the package base. A decrease in these resistances can allow increased component packing density in MCMs, reduction of heat sink volume in tightly packed systems, enable the use of higher performance circuit components, and improve reliability. The substrate for high power density devices is the primary thermal link between the junctions and the heat sink. Present high power multichip modules and single chip packages use substrate materials such as silicon nitride or copper tungsten that have thermal conductivity in the range of 200 W/mK. We have developed Dymalloy, a copper-diamond composite, that has a thermal conductivity of 420 W/mK and an adjustable coefficient of thermal expansion, nominally 5.5 ppm/C at 25 C, compatible with silicon and gallium arsenide. Because of the matched coefficient of thermal expansion it is possible to use low thermal resistance hard die attach methods. Dymalloy is a composite material made using micron size Type I diamond powder that has a published thermal conductivity of 600 to 1000 W/mK in a metal matrix that has a thermal conductivity of 350 W/mK. The region of chemical bonding between the matrix material and diamond is limited to approximately 1000 A to maintain a high effective thermal conductivity for the composite. The material may be fabricated in near net shapes. Besides having exceptional thermal properties, the mechanical properties of this material also make it an attractive candidate as an electronic component substrate material.
Distinct Sites of Insulin-Like Growth Factor (IGF)-II Expression and Localization in Lesioned Rat Brain: Possible Roles of IGF Binding Proteins (IGFBPs) in the Mediation of IGF-II Activity (1999)

Although expression of the IGF-II has been demonstrated within the central nervous system (CNS), past studies have failed to reveal its precise roles or responses subsequent to a traumatic injury. To demonstrate that IGF-II, IGFBP, and IGF receptor (-R) expression alters in response to a penetrating CNS injury, we used the techniques of ribonuclease protection assay, in situ hybridization, immunohistochemistry, Western blotting, and RIA. Under normal physiology, IGF-II expression is restricted to the mesenchymal support structures of the brain, including the choroid plexus, where its expression is coincident with that of IGFBP-2. Between 1–7 days post lesion (dpl), in the acute phase following a penetrant wound to the CNS, IGF-II and IGF-IIR protein, but not messenger RNA, were colocalized, with IGF-I, IGF-IR, and IGFBP-1, -2, -3, and -6, to neurons, macrophages, astrocytes, and microglia within the damaged tissue. Within the cerebrospinal fluid (CSF), levels of IGF-II peptide increased to peak at 7 dpl. IGFBP-2, -3, and -6 were also observed within the CSF, with IGFBP-2 predominating and exhibiting an increase in binding efficiency from 7–10 dpl. In the chronic phase of injury (7–14 dpl), an increase in both IGF-II, IGF-IIR and IGFBP-5 messenger RNA and protein was observed specifically and focally in the marginal astrocytes forming the limiting glial membrane of the wound. Thus, our evidence suggests that there are two mechanisms of action for IGF-II within the injured rat brain. During the acute phase, the secretion of IGF-II from the choroid plexus into the CSF is up-regulated, resulting in increased transport of the peptide to the wound. In the CSF, transported IGF-II is complexed to IGFBP-2 and essentially demonstrates an endocrine mode of action with a balance of locally produced IGFBPs modulating its bioactivity in the wound. Later in the wounding response, levels of IGF-II decline in the CSF and the wound neuropil, possibly with the aid of increased IGFBP-5 levels that may help to locally sequester and down-regulate IGF-II activity. Hence, in the chronic phase of the injury response, IGF-II reasserts itself to a predominantly autocrine/paracrine role restricted to the mesenchymal support structures, including the glia limitans, which may help reestablish and maintain tissue homeostasis.
IBM POWER8 processor core microarchitecture (2015)

The POWER8™ processor is the latest RISC (Reduced Instruction Set Computer) microprocessor from IBM. It is fabricated using the company's 22-nm Silicon on Insulator (SOI) technology with 15 layers of metal, and it has been designed to significantly improve both single-thread performance and single-core throughput over its predecessor, the POWER7® processor. The rate of increase in processor frequency enabled by new silicon technology advancements has decreased dramatically in recent generations, as compared to the historic trend. This has caused many processor designs in the industry to show very little improvement in either single-thread or single-core performance, and, instead, larger numbers of cores are primarily pursued in each generation. Going against this industry trend, the POWER8 processor relies on a much improved core and nest microarchitecture to achieve approximately one-and-a-half times the single-thread performance and twice the single-core throughput of the POWER7 processor in several commercial applications. Combined with a 50% increase in the number of cores (from 8 in the POWER7 processor to 12 in the POWER8 processor), the result is a processor that leads the industry in performance for enterprise workloads. This paper describes the core microarchitecture innovations made in the POWER8 processor that resulted in these significant performance benefits.
Use of Anti-fluorophore Antibody to Achieve High-sensitivity Immunolocalizations of Transporters and Ion Channels (2006)

We have discovered that the immunoreactivity of the fluorophore Alexa Fluor 488 survives glutaraldehyde and osmium tetroxide fixation and epoxy resin embedding and etching. We have developed new localization methods that for the first time take advantage of this property. The antigen is localized in cryosections using suitable primary antibody and an Alexa Fluor 488-conjugated secondary antibody. Cryosection fluorescence can be photographed for later correlation with electron microscopy (EM) findings. The sections are then further fixed with glutaraldehyde and OsO4, if desired and flat-embedded in epoxy resin. Semi-thin sections are etched completely with sodium ethoxide, whereas thin sections are partially etched. Alexa Fluor 488 is then localized with rabbit anti-Alexa Fluor 488 and goat anti-rabbit conjugated to Alexa Fluor 488 [light microscopy (LM)] or to colloidal gold (EM). A second antigen may also be localized using Alexa Fluor 568. When used without postfixation, these methods produce high-resolution semi-thin, or even thin, sections that retain a high level of fluorescence for LM observations. These methods allow highly sensitive immunolocalizations in tissue while preserving cell fine structure through traditional fixation and epoxy embedding. In demonstration of the methods, we describe the localization of the thiazide-sensitive sodium/chloride cotransporter and the epithelial sodium channel in rat kidney.
Using calcium chloride injection to improve tenderness of beef from mature cows1 (1991)

The objective of this investigation was to determine the effect of calcium chloride (CaCl2) injection on Warner-Bratzler shear force (WBS), sensory panel ratings, and collagen traits of mature cow beef. Within 30 min of exsanguination, subprimals (top round, TR; top sirloin, TS; strip loin, SL) from alternate sides of the carcass were injected with a .3 M CaCl2 solution (10% of the subprimal weight) and aged for 1, 7, or 14 d. The corresponding cold-boned cuts of the other side served as a control. Injecting CaCl2 eliminated the requirement for extended postmortem storage, as indicated by d 1 WBS. During the 14-d aging period, WBS of noninjected cuts decreased by 2.59 kg, whereas WBS of CaCl2-injected samples decreased by only .35 kg. Compared with control cuts, CaCl2 injection improved (P less than .05) d-14 WBS of steaks from SL, TS, and TR by 41.1, 40.1, and 15.3%, respectively. Additionally, CaCl2-injected subprimals exhibited higher (P less than .05) sensory panel tenderness ratings, lower (P less than .05) amounts of detectable connective tissue, and shorter (P less than .05) sarcomere lengths. No differences (P greater than .05) were observed in any quantitative collagen traits between CaCl2-injected and control cuts. These results indicate that CaCl2 injection improved ultimate tenderness and sensory ratings of meat from mature cow cuts.
Monolithic Photorefractive Organic Glasses with Large Coupling Gain and Strong Beam Fanning (2002)

A monolithic photorefractive organic glass with large gain coefficients at low electric fields is presented. The molecule DCDHF-6 (see Figure) acts simultaneously as charge transport material and nonlinear optical chromophore. Strong beam fanning is observed with suppression of the initial beam to 25 % of its initial value in samples only 100 μm thick.
P<scp>ost-translational</scp> M<scp>odifications of</scp> SIBLING P<scp>roteins and</scp> T<scp>heir</scp> R<scp>oles in</scp> O<scp>steogenesis and</scp> D<scp>entinogenesis</scp> (2004)

The extracellular matrix (ECM) of bone and dentin contains several non-collagenous proteins. One category of non-collagenous protein is termed the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family, that includes osteopontin (OPN), bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP), and matrix extracellular phosphoglycoprotein (MEPE). These polyanionic SIBLING proteins are believed to play key biological roles in the mineralization of bone and dentin. Although the specific mechanisms involved in controlling bone and dentin formation are still unknown, it is clear that some functions of the SIBLING family members are dependent on the nature and extent of post-translational modifications (PTMs), such as phosphorylation, glycosylation, and proteolytic processing, since these PTMs would have significant effects on their structure. OPN and BSP are present in the ECM of bone and dentin as full-length forms, whereas amino acid sequencing indicates that DMP1 and DSPP exist as proteolytically processed fragments that result from scission of X-Asp bonds. We hypothesized that the processing of DMP1 and DSPP is catalyzed by the PHEX enzyme, since this protein, an endopeptidase that is predominantly expressed in bone and tooth, has a strong preference for cleavage at the NH2-terminus of aspartyl residue. We envision that the proteolytic processing of DMP1 and DSPP may be an activation process that plays a significant, crucial role in osteogenesis and dentinogenesis, and that a failure in this processing would cause defective mineralization in bone and dentin, as observed in X-linked hypophosphatemic rickets.
Leaching of Toluene−Neoprene Adhesive Wastes (2001)

This work consists of the study of the extraction of solvent (toluene) from a polymeric (neoprene) substrate during a leaching process. Total organic carbon (TOC) is the main contaminant parameter in the leaching of these systems due to the solution of the toluene and the dispersion of the polymer. The toxicity of the extracts was measured with a Microtox equipment, using Photobacteria phosphoreum, deducing that the toxicity of the extracts is low due to the low solubility of toluene but that the toxicity of toluene is high. On the basis of the experimental results, the amount of toluene diffused vs time in plane sheet systems was studied. A kinetic model has been developed considering two stages: In the first stage, the toluene diffuses into the system across the neoprene chains at a constant rate, not depending on the initial toluene concentration. This fact is explained by considering that there is a constant difference of the toluene concentration between the interface with the water and the inner part of the sample. In the second stage, the dispersion of the polymer with the corresponding amount of toluene takes place. The diffusion of toluene in the leaching process is compared and analyzed considering the diffusion of toluene in a desorption process in air so that the difference of toluene concentration between the interface and the interior can be estimated. A mathematical model is also proposed for considering the leaching process in other operating conditions.
Berichtmuster zur Überprüfung einer Einkaufsabteilung (1957)

Der Auftrag zur Organisationsprüfung des Einkaufsektors der TEST A. G. ist dem Berichter am 21. Mai 1957 durch den kaufmännischen Direktor des Werkes, Herrn Diefenbach, erteilt worden.
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development. (1997)

In situ hybridization of mouse embryo sections demonstrated expression of mRNAs encoding two polypeptide inhibitors (p18INK4c and p19INK4d) of cyclin D-dependent kinase (CDK) 4 and CDK6 in the central nervous system. No expression of two other INK4 members, p16INK4a and p15INK4b, was observed. The p19INK4d and p18INK4c proteins formed complexes with either CDK4 or CDK6 in a temporal pattern consistent with the results of in situ hybridization. Expression of INK4c was observed at embryonic day 13.5 in neuroepithelial zones of the developing brain, being restricted to dividing neuroblasts but absent from differentiating postmitotic neurons. In the neocortex, p18INK4c was expressed precisely at those developmental stages when neuroblasts switch from a symmetric to an asymmetric pattern of cell division with concomitant increases in their G1 interval. INK4d RNA was detected from embryonic day 11.5 onward, at higher levels than INK4c and with a distinctly different spatial and temporal pattern. Marked INK4d expression was seen in dorsal root ganglia, spinal cord, and focally throughout the brain, but primarily in postmitotic neurons. Neural expression of INK4d continued postnatally into adulthood in postmitotic cells of the dentate gyrus, the pyramidal layer of the hippocampus, and in discrete regions of the cerebral cortex, cerebellum, thalamus, and brainstem. Downregulation of p19INK4d in the dentate gyrus after kainic acid-induced seizures indicated that its expression could also be modified in nondividing cells by excitotoxic stress. Therefore, p19INK4d may contribute to maintaining the quiescent state, acting as a buffer to prevent reactivation of cyclin D-dependent kinases in terminally differentiated cells.
Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. (1990)

The New Zealand white (NZW) rabbit fed a 0.1% cholesterol-enriched diet (CD) typically responds (normoresponsive, NR) by quickly developing hypercholesterolemia. To study the underlying mechanisms responsible for the widespread phenomenon of inter-individual variability of response to dietary cholesterol, a unique hypercholesterolemia-resistant (RT) rabbit model was developed. These animals were utilized to investigate selected potential mechanisms that might enable the RT animal to compensate for dietary cholesterol overload. When rabbits were fed the low-cholesterol stock diet, there was no significant difference in the plasma cholesterol concentrations of the NR and the RT animals. However, a significant rise was observed in the NR rabbits within 1 month of their being placed on the cholesterol-enriched diet; the plasma cholesterol concentration of the RT animals was not affected. During consumption of the cholesterol diet the cholesterol absorption rate was somewhat greater in the NR rabbits (P less than 0.05), whereas intestinal transit times and the fecal excretion of neutral steroids were substantially the same in both groups. In contrast, the fecal bile acid excretion of the RT animals was more than twice as great (P less than 0.0001) as that of the NR animals. We conclude that the response to dietary cholesterol is a heritable trait in these rabbits and that, although less dietary cholesterol was absorbed by the RT animals, it appears that a major mechanism controlling plasma cholesterol levels involves the rate of conversion of cholesterol to bile acids and their subsequent excretion.
Monolithic integration of spot-size converters with 1.3-μm lasers and 1.55-μm polarization insensitive semiconductor optical amplifiers (1997)

To reduce packaging costs, it is necessary to use passive alignment between the laser diodes and optical fiber. Such an alignment requires low-coupling loss and large positional alignment tolerances. This is achievable with integrated spot-size converters, which permit to match the near field of a laser to that of a flat-end single-mode fiber (SMF). In this paper, we first review briefly the different technological approaches to realize spot-size converters. Then, we focus on the double-core structure developed both for 1.3-/spl mu/m Fabry-Perot lasers and 1.55-/spl mu/m semiconductor optical amplifiers (SOAs). The spot-size expansion is simulated using a two-dimensional (2-D) beam propagation method analysis. Short spot-size converters (100 /spl mu/m) integrated with 1.3-/spl mu/m lasers and 1.55-/spl mu/m SOAs exhibit beam divergences as low as 12/spl deg//spl times/12/spl deg/ and 12/spl deg//spl times/15/spl deg/, respectively. The performances of devices with integrated spot-size converters are reported and discussed. A 2-in wafer process is used thanks to the versatility of the double-core structure and its compatibility with buried ridge stripe technology.
Science and Policy in the Marine Realm (2007)

Resource management in the Southern Ocean began with the International Whaling Commission (IWC), but was later developed through the Seals Convention and CCAMLR (the Convention on the Conservation of Antarctic Marine Living Resources). These strongly focused bodies and the close relationship between scientists and policymakers has resulted in a collaborative approach to the development of policy, and a strategic approach to science, based on policy needs. Australia entered the field of Antarctic marine research in the early 1980s, after development of the krill fishery and the emergence of CCAMLR as the international body established to manage this, and other fisheries, in the Southern Ocean. With the development of domestic fisheries for Patagonian toothfish and mackerel icefish at Heard Island and McDonald Islands (HIMI), and at Macquarie Island in the 1990s, the Australian Antarctic Division focussed on providing targeted information to policy-makers that enabled direct management of these fisheries. The Australian Antarctic Division's Southern Ocean Ecosystems programme maintains its focus on supporting Australia's position in key forums - including CCAMLR , the IWC and the Agreement on the Conservation of Albatrosses and Petrels. In collaboration with our partners at the Antarctic Climate and Ecosystems Cooperative Research Centre we are also able to address issues relating to the effects of climate change on Southern Ocean ecosystems. Such strongly focussed research programmes are thus capable of serving several masters simultaneously, whilst at the same time producing world-class science.
Vestibular Evoked Potentials (VestEP) and Brain Electrical Activity Mapping - A Test of Vestibular Function - A Review (1990 - 1996). (1996)

Brain Electrical Activity Mapping of Vestibular Evoked Potentials (BEAM-VestEP) is a new technology for investigation of the spatial and temporal properties of a rotationally-induced brain electrical events. The method consists of multichannel EEG registration and mapping of the brain isoelectrical contours during short-lasting repetitive angular accelerations. A special data bank containing more than 400 BEAM-VestEP investigations on more than 300 persons, either symptom free volunteers or neurotological patients suffering from vertigo, tinnitus, sudden hearing loss, acoustic tumors, balance disorders, has been created for this study. The VestEP wave set consists of 5 - 7 positive/negative wave components, appearing within the time interval of 70 - 850 ms after the onset of the acceleratory step stimulus. The principle components analysis reveals that the shortest latencies and the highest amplitudes of the VestEPs can be registered from the central transversal line of electrodes, T3-C3-Cz-C4-T4. The later components are generated from the more frontally located cortical areas. The VestEP is a compound electrical phenomenon. The initial complex ( waves I - III) is related to the activation of specific (vestibular) cortical areas. The later complex (waves IV - VI) reflects the supramodal cortical proceedings with sensory information (cognitive components).