gebhart/patrepeval huggingface dataset:
Risk Stratification in the Long-QT Syndrome (2003)

The locus of the causative mutation affects the clinical course of the long-QT syndrome and modulates the effects of the QTc and sex on clinical manifestations. We propose an approach to risk stratification based on these variables.
A framework for knowledge management in requirements engineering (2018)

Managing knowledge properly has become a necessity in all types of professional activities, especially in those whose products are highly utilised and disseminated, such as software engineering. Because we live in a software-dependent society, this technological development requires improving the processes of understanding and manufacturing; thus, it is recommended to use knowledge as a basis to achieve such improvements. This paper presents the results of an analysis of the proposals to manage knowledge in requirements engineering, in which it is evident that the proposals fail to meet the needs of work teams. The practices evaluated in this study propose an integrated framework for the management of knowledge in RE comprised by the conjunction between the phases of knowledge and the stages of RE and characterised by including two principles of complex thought: transdisciplinarity and multidimensionality.
Literature review on the management of diabetic foot ulcer (2015)

Diabetic foot ulcer (DFU) is the most costly and devastating complication of diabetes mellitus, which affect 15% of diabetic patients during their lifetime. Based on National Institute for Health and Clinical Excellence strategies, early effective management of DFU can reduce the severity of complications such as preventable amputations and possible mortality, and also can improve overall quality of life. The management of DFU should be optimized by using a multidisciplinary team, due to a holistic approach to wound management is required. Based on studies, blood sugar control, wound debridement, advanced dressings and offloading modalities should always be a part of DFU management. Furthermore, surgery to heal chronic ulcer and prevent recurrence should be considered as an essential component of management in some cases. Also, hyperbaric oxygen therapy, electrical stimulation, negative pressure wound therapy, bio-engineered skin and growth factors could be used as adjunct therapies for rapid healing of DFU. So, it's suggested that with appropriate patient education encourages them to regular foot care in order to prevent DFU and its complications.
The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology (2016)

The main purpose of urine cytology is to detect high-grade urothelial carcinoma (HGUC). With this principle in mind, The Paris System (TPS) Working Group, composed of cytopathologists, surgical pathologists, and urologists, has proposed and published a standardized reporting system that includes specific diagnostic categories and cytomorphologic criteria for the reliable diagnosis of HGUC. This paper outlines the essential elements of TPS and the process that led to the formation and rationale of the reporting system. The Paris System Working Group, organized at the 2013 International Congress of Cytology, conceived a standardized platform on which to base cytologic interpretation of urine samples. The widespread dissemination of this approach to cytologic examination and reporting of urologic samples and the scheme's universal acceptance by pathologists and urologists is critical for its success. For urologists, understanding the diagnostic criteria, their clinical implications, and the limitations of TPS is essential if they are to utilize urine cytology and noninvasive ancillary tests in a thoughtful and practical manner. This is the first international/inclusive attempt at standardizing urinary cytology. The success of TPS will depend on the pathology and urology communities working collectively to improve this seminal paradigm shift, and optimize the impact on patient care.
Practical Chemistry Modeling Applied to Process Design Studies (1998)

Chemistry modeling is capable of accurately predicting the physical, material, and performance properties of both established and new materials and processes. A relatively new technology, it is gaining rapid acceptance as a way to understand practical industrial chemical problems in a structured and detailed manner. Based on quantum chemistry, chemistry modeling is a novel science that uses theoretical models and computer software instead of experimental observation to measure the properties of molecules. This paper discusses how chemistry modeling assists engineers in the design, pilot, and production stages of chemical processes. Several current examples taken from the modern chemical industry are reported. Finally, the promise of chemistry modeling as a modern business tool is addressed.
Preparation of Rh[16aneS<sub>4</sub>-diol]<sup>211</sup>At and Ir[16aneS<sub>4</sub>-diol]<sup>211</sup>At Complexes as Potential Precursors for Astatine Radiopharmaceuticals. Part I: Synthesis (2008)

The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to microwave radiation. In conclusion, this study has shown that it is possible to attach an astatide anion to soft metal cations in a simple and fast one-step procedure, with high yields. These complexes will be evaluated as reagents for labeling biomolecules.
Beyond Bounding Boxes: Using Bounding Shapes for Real-Time 3D Vehicle Detection from Monocular RGB Images. (2019)

The representation of objects as 2D bounding boxes in monocular RGB images limits the faculty of current computer vision systems to 2D object detection. It fails to provide crucial information such as the orientation of other vehicles, which is vital for autonomous driving. At the same time, real-time performance is essential to qualify an approach for deployment in a productive environment. In order to tackle this problem, we present an approach that predicts several key points selected from a virtual 3D bounding box around a vehicle instead of a pure 2D bounding box. These key points can be interpreted as a bounding shape. With this novel representation we can calculate the actual 3D bounding box of the corresponding object. Thanks to the straightforward implementation of bounding shape in any current state-of-the-art 2D object detector both for singleshot frameworks like YOLO or SSD as well as for two-stage detectors like Faster-RCNN with a minimum of computational overhead, it is able to be run in real-time while providing additional useful information for vehicle detection. We exemplify the extension of SSD to Bounding Shape SSD ( $\text{BS}^{3}\mathrm{D}$ ) and evaluate our approach using the challenging KITTI as well as the novel VIPER dataset.
Transoceanic Transmission of 40$\,\times\,$117.6 Gb/s PDM-OFDM-16QAM Over Hybrid Large-Core/Ultralow-Loss Fiber (2012)

We experimentally demonstrated transmitting 40 × 117.6 Gb/s 16 quadrature amplitude modulation with orthogonal frequency division multiplexing modulation over 10 181 km. The following techniques are applied to achieve error-free transmission: 1) hybrid large-core/ultralow-loss fibers were used for improving received optical signal-to-noise ratio while enhancing fiber nonlinearity tolerance; 2) multiband nonlinearity compensation algorithm was performed to further improve nonlinearity tolerance; 3) the forward error correction (FEC) limit of 5.3 dB provided by the concatenation of hard-decision and soft-decision FEC codes ensures to have error-free transmission after turbo equalizer with memory of three symbols, thus attaining a spectral efficiency of 4.7 b/s/Hz.
Immune Responses Detected in Urothelial Carcinoma Patients After Vaccination With NY-ESO-1 Protein Plus BCG and GM-CSF (2008)

Urothelial carcinoma of the bladder is a solid tumor entity for which the immunomodulatory agent Bacillus-Calmette Guerin (BCG) has been shown to have substantial efficacy with approximately 90% cure rates in select patients with superficial disease. Immune-based therapies for patients with more invasive disease do not currently exist. We previously showed that invasive urothelial carcinomas express the NY-ESO-1 tumor antigen. Here we evaluated the safety and immunogenicity of a recombinant NY-ESO-1 protein vaccine, which was administered with granulocyte macrophage colony-stimulating factor and BCG as immunologic adjuvants in a cohort of urothelial carcinoma patients. Sixty-two urothelial carcinoma patients were screened for enrollment onto the vaccine clinical trial and 6 patients met all eligibility criteria to receive vaccination. Patients with localized disease underwent surgical removal of their bladders as treatment for their disease. Tumor tissues were tested for NY-ESO-1 expression and eligible patients, shown to have NY-ESO-1 tumors, were vaccinated in the postoperative setting. Peripheral blood samples were analyzed for vaccine-induced antibody and T-cell responses. The vaccine regimen was well tolerated with only mild injection site reactions. NY-ESO-1-specific antibody responses were induced in 5/6 patients whereas CD8 T-cell responses occurred in 1/6 patients and CD4 T-cell responses were found in 6/6 patients. This study demonstrates safety and feasibility of the NY-ESO-1 recombinant protein in combination with BCG and granulocyte macrophage colony-stimulating factor to induce predominantly antibody and CD4 T-cell responses in urothelial carcinoma patients. Induction of higher frequency of CD8 T-cell responses may be possible in clinical trials implementing NY-ESO-1 vaccination in combination with other immunomodulatory agents.
Induction of heat shock protein 70 (Hsp70) by proteasome inhibitor MG 132 protects articular chondrocytes from cellular death in vitro and in vivo (2004)

The aim of this work was to determine whether Hsp70 overexpression via proteasome inhibitor MG132 was able to protect chondrocytes towards mono-iodoacetate (MIA) cytotoxicity both in vitro and in vivo. In vitro, overexpression of Hsp70 via MG132 was significantly able to protect chondrocytes from MIA toxicity (MTT/LDH analyses). Hsp70 essentially mediated this chondroprotective effect as demonstrated by antisense strategy. In vivo, chondrocytic overexpression of Hsp70, after a preventive intra-articular injection of MG132 in rat knee, was sufficient to decrease the severity of OA-induced MIA lesions, as demonstrated histologically and biochemically. In conclusion, intracellular overexpression of Hsp70, through proteasome inhibition, could be an interesting tool in protecting chondrocytes from cellular injuries, either necrotic or apoptotic in nature, and thus might be a novel chondroprotective modality in rat experimental OA.
SELECTIVE INHIBITION OF THE ACTIVITY OF INDUCIBLE NITRIC OXIDE SYNTHASE PREVENTS THE CIRCULATORY FAILURE, BUT NOT THE ORGAN INJURY/DYSFUNCTION, CAUSED BY ENDOTOXIN (1998)

Inhibitors of nitric oxide synthase (NOS) attenuate the circulatory failure caused by endotoxin, but the role of NO in the development of multiple organ dysfunction and the relative contribution of NO produced by endothelial NOS and inducible NOS (iNOS) to organ injury remains unclear. Here we report for the first time that 1400W, a novel and highly selective inhibitor of iNOS activity, attenuates the delayed hypotension as well as the rise in the plasma levels of nitrite/nitrate caused by endotoxin in the rat. Inhibition of iNOS activity with 1400W administered either before or 2 h after endotoxin injection did not, however, attenuate the hepatocellular injury, renal dysfunction, or pancreatic injury in this model. Similarly, administration of another selective inhibitor of iNOS activity, L-NIL, 2 h after endotoxin injection abolished the rise in nitrite/nitrate and attenuated the delayed hypotension caused by endotoxin, but failed to ameliorate organ injury. Thus, selective inhibition of iNOS activity with 1400W attenuates the circulatory failure induced by endotoxin in the rat, but fails to influence the degree of organ injury/dysfunction.
Synthesis of Conformationally Restricted and Optically Pure Analogues of Serine-Proline Dipeptide via Aldol Condensation (2004)

Corrected by: Synthesis of Conformationally Restricted and Optically Pure Analogues of Serine­-Proline Dipeptide via Aldol CondensationSynthesis 2004; 2004(05): 0810-0810DOI: 10.1055/s-2004-822319
Adaptive compensation of analog front-end I/Q mismatches in digital receivers (2002)

I and Q channel phase and gain mismatches are of great concern in communications receiver design. In this paper we analyse the effects of I and Q channel mismatches and propose a low-complexity blind adaptive algorithm to minimize this problem. The proposed solution consists of two, 2-tap adaptive filters, arranged in Adaptive Noise Canceller (ANC) set-up, with the output of one cross-fed to the input of the other. The system works as a de-correlator eliminating I and Q mismatch errors.
On-a-chip microdischarge thruster arrays inspired by photonic device technology for plasma television (2009)

This study shows that the practical scaling of a hollow cathode thruster device to MEMS level should be possible albeit with significant divergence from traditional design. The main divergence is the need to operate at discharge pressures between 1-3bar to maintain emitter diameter pressure products of similar values to conventional hollow cathode devices. Without operating at these pressures emitter cavity dimensions become prohibitively large for maintenance of the hollow cathode effect and without which discharge voltage would be in the hundreds of volts as with conventional microdischarge devices. In addition this requires sufficiently constrictive orifice diameters in the 10µm – 50µm range for single cathodes or &lt;5µm larger arrays. Operation at this pressure results in very small Debye lengths (4 -5.2pm) and leads to large reductions in effective work function (0.3 – 0.43eV) via the Schottky effect. Consequently, simple work function lowering compounds such as lanthanum hexaboride (LaB<sub>6</sub>) can be used to reduce operating temperature without the significant manufacturing complexity of producing porous impregnated thermionic emitters as with macro scale hollow cathodes, while still operating &lt;1200°C at the emitter surface. The literature shows that LaB<sub>6</sub> can be deposited using a variety of standard microfabrication techniques.
KIDNEY TRANSPLANTS IN CYCLOSPORINE-TREATED SPRAGUE-DAWLEY RATS (1990)

Previous studies by others have shown that transplanted rat kidneys have abnormally low clearances of paraaminohippuric acid, inulin, and creatinine, due to rejection and/or to warm-ischemia-induced injury. In the present studies, randomly bred Sprague-Dawley rats were used as donors and recipients. The left kidneys of recipients were removed, and the right kidneys were left intact. Donor kidneys were flushed with an ice-cold hypertonic solution (150 mM NaCl, 200 mM mannitol, pH 6.4), and the kidneys were kept cold during surgery. Renal function was assessed 1 week later. The left transplanted kidneys in untreated recipients exhibited morphologic evidence of rejection, and the clearances of PAH and inulin were approximately 50% of those of the right native kidneys. CsA-treated rats did not reject the transplants, and the PAH and inulin clearances of the left transplanted kidneys were identical to those of the right native kidneys. Untreated and CsA-treated rats with both native kidneys intact served as controls. The amount of CsA given during the 7-day period produced no measurable change in renal function. This is the first demonstration of virtually normal hemodynamics in transplanted rat kidneys when randomly bred animals are used as donors and recipients. Moreover, the results indicate that if both rejection and warm ischemia are avoided, the presence of a functioning native kidney does not have a detrimental effect on the function of a transplanted kidney.
Understanding the role of L-type lectin receptor kinases in Phytophthora resistance (2014)

Phytophthora capsici causes devastating diseases on a broad range of plant species.To better understand the interaction with its host plants, knowledge obtained from a model pathosystem can be instrumental.Here we describe the interaction between P. capsici and Arabidopsis and the exploitation of this novel pathosystem to assign metabolic pathways involved in defence against P. capsici.Inoculation assays on Arabidopsis accessions with different P. capsici isolates revealed interaction specificity among accession-isolate combinations.In a compatible interaction, appressorium-mediated penetration was followed by the formation of invasive hyphae, haustoria and sporangia in leaves and roots.In contrast, in an incompatible interaction, P. capsici infection elicited callose deposition, accumulation of active oxygen species and cell death, resulting in early pathogen encasement in leaves.Moreover, Arabidopsis mutants with defects in salicylic acid signaling, camalexin or indole glucosinolates biosynthesis pathways displayed severely compromised resistance to P. capsici.It is anticipated that this model pathosystem will facilitate the genetic dissection of complex traits responsible for resistance against P. capsici.
Purification, characterization, and metabolic function of tungsten-containing aldehyde ferredoxin oxidoreductase from the hyperthermophilic and proteolytic archaeon Thermococcus strain ES-1 (1995)

Thermococcus strain ES-1 is a strictly anaerobic, hyperthermophilic archaeon that grows at temperatures up to 91 degrees C by the fermentation of peptides. It is obligately dependent upon elemental sulfur (S(o)) for growth, which it reduces to H2S. Cell extracts contain high aldehyde oxidation activity with viologen dyes as electron acceptors. The enzyme responsible, which we term aldehyde ferredoxin oxidoreductase (AOR), has been purified to electrophoretic homogeneity. AOR is a homodimeric protein with a subunit M(r) of approximately 67,000. It contains molybdopterin and one W, four to five Fe, one Mg, and two P atoms per subunit. Electron paramagnetic resonance analyses of the reduced enzyme indicated the presence of a single [4Fe-4S]+ cluster with an S = 3/2 ground state. While AOR oxidized a wide range of aliphatic and aromatic aldehydes, those with the highest apparent kcat/Km values (> 10 microM-1S-1) were acetaldehyde, isovalerylaldehyde, and phenylacetaldehyde (Km values of < 100 microM). The apparent Km value for Thermococcus strain ES-1 ferredoxin was 10 microM (with crotonaldehyde as the substrate). Thermococcus strain ES-1 AOR also catalyzed the reduction of acetate (apparent Km of 1.8 mM) below pH 6.0 (with reduced methyl viologen as the electron donor) but at much less than 1% of the rate of the oxidative reaction (with benzyl viologen as the electron acceptor at pH 6.0 to 10.0). The properties of Thermococcus strain ES-1 AOR are very similar to those of AOR previously purified from the saccharolytic hyperthermophile Pyrococcus furiosus, in which AOR was proposed to oxidize glyceraldehyde as part of a novel glycolytic pathway (S. Mukund and M. W. W. Adams, J. Biol. Chem. 266:14208-14216, 1991). However, Thermococcus strain ES-1 is not known to metabolize carbohydrates, and glyceraldehyde was a very poor substrate (kcat/Km of < 0.2 microM-1S-1) for its AOR. The most efficient substrates for Thermococcus strain ES-1 AOR were the aldehyde derivatives of transaminated amino acids. This suggests that the enzyme functions to oxidize aldehydes generated during amino acid catabolism, although the possibility that AOR generates aldehydes from organic acids produced by fermentation cannot be ruled out.
Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study (2010)

Tapentadol ER (100 - 250 mg b.i.d.) effectively relieved moderate to severe chronic low back pain over 15 weeks and had better gastrointestinal tolerability than oxycodone HCl CR (20 - 50 mg b.i.d.).
FREE FLIGHT TECHNOLOGY REQUIREMENTS AND LIABILITY ISSUES THAT MAY ARISE FOR EQUIPMENT MANUFACTURERS. (1997)

Imagine a better way.One that frees you to go your own way.Choosing your own optimum routes, speeds and flight levels.IFR-direct
Production of Inconel 718 Mortar Tubes by Hydrostatic Extrusion (1974)

Abstract : Using subscale tubes, extrusion parameters were developed and then applied to full size 60mm tubes. It was shown that tubes can be satisfactorily produced at a reduced cost. Estimates were developed to mass produce hydrostatically extruded tubes. The processing parameters, dimensional results and economic analysis are presented in detail.
Object recognition and pose estimation from 3D-geometric relations (2002)

We present a method for object recognition and pose estimation from noisy range data as provided by stereo processing. From the range dates, points of high surface curvature are estimated. By comparing three-point geometric relations, hypothetical correspondences are established between data and model points of high curvature. The hypothetical correspondences give rise to pose hypotheses which are evaluated with respect to the raw range data using a crude surface model. We show examples that demonstrate the method's tolerance to noise and occlusion.
Automatic Reasoning about Causal Events in Surveillance Video (2011)

We present a new method for explaining causal interactions among people in video. The input to the overall system is video in which people are low/medium resolution. We extract and maintain a set of qualitative descriptions of single-person activity using the low-level vision techniques of spatiotemporal action recognition and gaze-direction approximation. This models the input to the "sensors" of the person agent in the scene and is a general sensing strategy for a person agent in a variety of application domains. The information subsequently available to the reasoning process is deliberately limited to model what an agent would actually be able to sense. The reasoning is therefore not a classical "all-knowing" strategy but uses these "sensed" facts obtained from the agents, combined with generic domain knowledge, to generate causal explanations of interactions. We present results from urban surveillance video.