gebhart/patrepeval huggingface dataset:
AIRLINE ARRIVAL PRIORITIZATION IN SEQUENCING AND SCHEDULING (1998)

The basic objective of arrival sequencing and scheduling in air traffic control automation is t o match traffic demand and airport capacity while minimizing delays. The principle underlying practical sequencing and scheduling algorithms currently in use is referred to as first-come-firstserved (FCFS). While this principle generates fair schedules when delays must be absorbed, it does not take into account airline priorities among individual flights. The development of new scheduling techniques which consider priorities expressed by air carriers will further reduce the economic impact of air traffic management (ATM) restrictions on the airlines. This will also lead to increased airline economic efficiency by allowing airlines to have greater control over their individual arrival banks of aircraft. NASA is exploring the possibility of allowing airlines t o express relative arrival priorities to ATM through the development of new sequencing and scheduling algorithms which take into account airline preferences. This paper introduces a method of scheduling a bank of arrival aircraft according to a preferred order of arrival instead of according t o an FCFS sequence based on estimated time of arrival at the runway. Fast-time simulation is used to evaluate the feasibility of this scheduling method. Results show that when compared with FCFS scheduling, the alternative scheduling method is often successful in reducing deviations from the preferred bank arrival order while causing little or no increase in scheduled delays.
Nuclear Data Relevant to the Production of the Positron Emitting Technetium Isotope <sup>94m</sup>Tc via the <sup>94</sup>Mo(p,n)-reaction (1993)

Article Nuclear Data Relevant to the Production of the Positron Emitting Technetium Isotope 94mTc via the 94Mo(p,n)-reaction was published on August 1, 1993 in the journal Radiochimica Acta (volume 62, issue 3).
Pulmonary Hypertension Induced in Rats by Monocrotaline and Chronic Hypoxia is Reduced by <i>p</i>-Chlorophenylalanine (1985)

We have studied the role of 5-hydroxytryptamine (5-HT) in monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats using p-chlorophenylalanine (PCPA) which inhibits 5-HT synthesis. We measured right ventricular mean systolic pressure (Prvs), right ventricular hypertrophy, medial thickness of muscular pulmonary arteries, and muscularization of pulmonary arterioles 17 days after a single dose of monocrotaline (60 mg/kg) and after 26 days of chronic hypobaric hypoxia (380 mm Hg). In monocrotaline pulmonary hypertension, pretreatment with PCPA (500 mg/kg) was associated with significant reductions (p less than 0.05) in Prvs (29%), right ventricular hypertrophy (33%), and medial thickness of muscular pulmonary arteries (14%). In chronic hypoxic pulmonary hypertension, pretreatment with PCPA was associated with significant reductions in Prvs (20%), right ventricular hypertrophy (28%), medial thickness of muscular pulmonary arteries (14%), and muscularization of pulmonary arterioles (47%). 5-HT may play a role in the development of monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats.
Wideband harmonic radar detection (2008)

Radio sites consist naturally of metallic structures. Metals are always covered by an oxide film due to the metal reacting chemically with the oxygen in air. The rate of this oxide formation depends largely on the environment. Any oxide film between metallic contacts will cause non-linearity. RF currents passing through these junctions would generate harmonics. When RF signals at two frequencies fl and f2 pass-through a non-linearity they create signals at their sum and difference frequencies. These are known as 'inter-modulation products'. This generation of inter-modulation products when radio waves interact with rusty parts is called as the 'Rusty Bolt Effect'. Radio spectrum is carefully controlled for optimal usage of the available frequencies so that different services operate in well-defined frequency channels. Ofcom has set some standards for radio site engineering. This set of standards is given in the document 'MPT 1331: Code of Practice for Radio Site Engineering'. Any transmission site which is not following these codes would likely cause interference to other users. It is important that radio engineers should check the sites for their compliance with these codes. If a particular radio site is causing interference due to the rusty-bolt effect, the corroded points must be located to minimize their effect using a Harmonic Radar. A 'Harmonic Radar' is a device that illuminates a region of space with RF waves and receives the harmonics of the transmitted frequencies. The received data can then be processed to find the exact location and mobility of the points causing the generation of these harmonics. It works on the principle of radar transmitting a chirp signal and receiving harmonics of the transmitting frequency. Work is currently being carried out at the 'Centre for Communication Systems' in Durham University funded by HMGCC on the design and implementation of a novel Wideband Harmonic Radar system. The radar system would employ advanced sub-systems i.e. a suitable waveform and multiple antenna arrays processing super-resolution algorithms for angular information.
Notes on Summer Birds of Guerrero (1944)

Journal Article Notes on Summer Birds of Guerrero Get access William B. Davis William B. Davis Department of Fish and Game, Agricultural and Mechanical College of Texas, College Station, Texas Search for other works by this author on: Oxford Academic Google Scholar The Condor, Volume 46, Issue 1, 1 January 1944, Pages 9–14, https://doi.org/10.2307/1364244 Published: 01 January 1944
Animal Models for the Study of Noninvasive Haemophilus influenzae Disease: Pulmonary Clearance Systems (1992)

Nontypeable Haemophilus influenzae are increasingly being recognized as an important cause of disease in the lower respiratory tract. Information about the pathogenesis of these infections has been limited until recently by the paucity of experimental animal models for studying the host-parasite interaction in vivo. Three different animal models for investigation of the interaction of nontypeable H. influenzae with the lower respiratory tract have been used: Two involve the evaluation of short-term pulmonary clearance in mice or rats, while a new, long-term infection model in rats mimics the more chronic bronchopulmonary infections sometimes caused by these organisms. Results obtained in these three model systems indicate that both humoral and cellular immune mechanisms are involved in immunity to lower respiratory tract disease due to nontypeable H. influenzae.
Refinement of Local and Long-Range Structural Order in Theophylline-Binding RNA Using <sup>13</sup>C−<sup>1</sup>H Residual Dipolar Couplings and Restrained Molecular Dynamics (2001)

13C-(1)H residual dipolar couplings (RDC) have been measured for the bases and sugars in the theophylline-binding RNA aptamer, dissolved in filamentous phage medium, and used to investigate the long-range structural and dynamic behavior of the molecule in the solution state. The orientation dependent RDC provide additional restraints to further refine the overall structure of the RNA-theophylline complex, whose long-range order was poorly defined in the NOE-based structural ensemble. Structure refinement using RDC normally assumes that molecular alignment can be characterized by a single tensor and that the molecule is essentially rigid. To address the validity of this assumption for the complex of interest, we have analyzed distinct domains of the RNA molecule separately, so that local structure and alignment tensors experienced by each region are independently determined. Alignment tensors for the stem regions of the molecule were allowed to float freely during a restrained molecular dynamics structure refinement protocol and found to converge to similar magnitudes. During the second stage of the calculation, a single alignment tensor was thus applied for the whole molecule and an average molecular conformation satisfying all experimental data was determined. Semirigid-body molecular dynamics calculations were used to reorient the refined helical regions to a relative orientation consistent with this alignment tensor, allowing determination of the global conformation of the molecule. Simultaneously, the local structure of the theophylline-binding core of the molecule was refined under the influence of this common tensor. The final ensemble has an average pairwise root mean square deviation of 1.50 +/- 0.19 A taken over all heavy atoms, compared to 3.5 +/- 1.1 A for the ensemble determined without residual dipolar coupling. This study illustrates the importance of considering both the local and long-range nature of RDC when applying these restraints to structure refinements of nucleic acids.
Retrieval Accuracy Of Very Large Dna-Based Databases Of Digital Signals (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
Elimination of glycerol and replacement with alternative products in ethanol fermentation by Saccharomyces cerevisiae (2010)

Glycerol is a major by-product of ethanol fermentation by Saccharomyces cerevisiae and typically 2-3% of the sugar fermented is converted to glycerol. Replacing the NAD(+)-regenerating glycerol pathway in S. cerevisiae with alternative NADH reoxidation pathways may be useful to produce metabolites of biotechnological relevance. Under fermentative conditions yeast reoxidizes excess NADH through glycerol production which involves NADH-dependent glycerol-3-phosphate dehydrogenases (Gpd1p and Gpd2p). Deletion of these two genes limits fermentative activity under anaerobic conditions due to accumulation of NADH. We investigated the possibility of converting this excess NADH to NAD(+) by transforming a double mutant (gpd1∆gpd2∆) with alternative oxidoreductase genes that might restore the redox balance and produce either sorbitol or propane-1,2-diol. All of the modifications improved fermentative ability and/or growth of the double mutant strain in a self-generated anaerobic high sugar medium. However, these strain properties were not restored to the level of the parental wild-type strain. The results indicate an apparent partial NAD(+) regeneration ability and formation of significant amounts of the commodity chemicals like sorbitol or propane-1,2-diol. The ethanol yields were maintained between 46 and 48% of the sugar mixture. Other factors apart from the maintenance of the redox balance appeared to influence the growth and production of the alternative products by the genetically manipulated strains.
Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS (2018)

A highly selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay has been described for the determination of asenapine (ASE) in presence of its inactive metabolites <i>N</i>-desmethyl asenapine (DMA) and asenapine-<i>N</i>-glucuronide (ASG). ASE, and ASE 13C-d3, used as internal standard (IS), were extracted from 300 µL human plasma by a simple and precise liquid-liquid extraction procedure using methyl <i>tert</i>-butyl ether. Baseline separation of ASE from its inactive metabolites was achieved on Chromolith Performance RP<sub>8e</sub> (100 mm × 4.6 mm) column using acetonitrile-5.0 mM ammonium acetate-10% formic acid (90:10:0.1, v/v/v) within 4.5 min. Quantitation of ASE was done on a triple quadrupole mass spectrometer equipped with electrospray ionization in the positive mode. The protonated precursor to product ion transitions monitored for ASE and ASE 13C-d3 were <i>m/z</i> 286.1 → 166.0 and <i>m/z</i> 290.0 → 166.1, respectively. The limit of detection (LOD) and limit of quantitation (LOQ) of the method were 0.0025 ng/mL and 0.050 ng/mL respectively in a linear concentration range of 0.050-20.0 ng/mL for ASE. The intra-batch and inter-batch precision (% CV) and mean relative recovery across quality control levels were ≤ 5.8% and 87.3%, respectively. Matrix effect, evaluated as IS-normalized matrix factor, ranged from 1.03 to 1.05. The stability of ASE under different storage conditions was ascertained in presence of the metabolites. The developed method is much simpler, matrix free, rapid and economical compared to the existing methods. The method was successfully used for a bioequivalence study of asenapine in healthy Indian subjects for the first time.
Dynamics of a rotating space station. (1968)

Equations formulated for space vehicle reaction to rotating machinery and internal mass motion, evaluating dynamics of cylindrical space station rotating about major axis
A Prospective PCR-Based Screening for the <i>EML4-ALK</i> Oncogene in Non–Small Cell Lung Cancer (2012)

Abstract Purpose: EML4-ALK is a lung cancer oncogene, and ALK inhibitors show marked therapeutic efficacy for tumors harboring this fusion gene. It remains unsettled, however, how the fusion gene should be detected in specimens other than formalin-fixed, paraffin-embedded tissue. We here tested whether reverse transcription PCR (RT-PCR)-based detection of EML4-ALK is a sensitive and reliable approach. Experimental Design: We developed a multiplex RT-PCR system to capture ALK fusion transcripts and applied this technique to our prospective, nationwide cohort of non–small cell lung cancer (NSCLC) in Japan. Results: During February to December 2009, we collected 916 specimens from 853 patients, quality filtering of which yielded 808 specimens of primary NSCLC from 754 individuals. Screening for EML4-ALK and KIF5B-ALK with our RT-PCR system identified EML4-ALK transcripts in 36 samples (4.46%) from 32 individuals (4.24%). The RT-PCR products were detected in specimens including bronchial washing fluid (n = 11), tumor biopsy (n = 8), resected tumor (n = 7), pleural effusion (n = 5), sputum (n = 4), and metastatic lymph node (n = 1). The results of RT-PCR were concordant with those of sensitive immunohistochemistry with ALK antibodies. Conclusions: Multiplex RT-PCR was confirmed to be a reliable technique for detection of ALK fusion transcripts. We propose that diagnostic tools for EML4-ALK should be selected in a manner dependent on the available specimen types. FISH and sensitive immunohistochemistry should be applied to formalin-fixed, paraffin-embedded tissue, but multiplex RT-PCR is appropriate for other specimen types. Clin Cancer Res; 18(20); 5682–9. ©2012 AACR.
Benefits and pitfalls of pegylated interferon-α2a therapy in patients with myeloproliferative neoplasm-associated myelofibrosis: a French Intergroup of Myeloproliferative neoplasms (FIM) study (2017)

We have previously described the safety and efficacy of pegylated interferon-α2a therapy in a cohort of 62 patients with myeloproliferative neoplasm-associated myelofibrosis followed in centers affiliated to the French Intergroup of Myeloproliferative neoplasms. In this study, we report their long-term outcomes and correlations with mutational patterns of driver and non-driver mutations analyzed by targeted next generation sequencing. The median age at diagnosis was 66 years old, the median follow-up since starting pegylated interferon was 58 months. At the time of analysis, 30 (48.4%) patients were alive including 16 still being treated with pegylated interferon. The median survival of patients with intermediate and high-risk prognostic Lille and dynamic International Prognostic Scoring System scores treated with pegylated interferon was increased in comparison to that of historical cohorts. In addition, overall survival was significantly correlated with the duration of pegylated interferon therapy (70 <i>versus</i> 30 months after 2 years of treatment, <i>P</i><10<sup>-12</sup>). <i>JAK2</i><sup>V617F</sup> allele burden was decreased by more than 50% in 58.8% of patients and two patients even achieved complete molecular response. Next-generation sequencing analyses performed in 49 patients showed that 28 (57.1%) of them carried non-driver mutations. The presence of at least one additional mutation was associated with a reduction of both overall and leukemia-free survival. These findings in a large series of patients with myelofibrosis suggest that pegylated interferon therapy may provide a survival benefit for patients with intermediate- or high-risk Lille and dynamic International Prognostic Scoring System scores. It also reduced the <i>JAK2</i><sup>V617F</sup> allele burden in most patients. These results further support the use of pegylated interferon in selected patients with myelofibrosis.
Diacetyl for Blocking the Histochemical Reaction for Arginine (1994)

Two different histochemical methods for blocking the guanidinium group of arginine in formalin fixed, paraffin embedded material are reported here. One procedure uses diacetyl with short incubation times and high pH, the other uses the trimer of the diacetyl reagent and requires longer incubation times but moderate pH. The diacetyl reagent is recommended despite its high pH because the preparation of the diacetyl trimer is laborious and time-consuming.
Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates. (1986)

S-(1,2-Dichlorovinyl)-L-homocysteine (DCVHcy), an analogue of the nephrotoxin S-(1,2-dichlorovinyl)-L-cysteine (DCVCys), is a much more potent nephrotoxin than DCVCys both in vivo and in isolated renal proximal tubular cells. S-(1,2-Dichlorovinyl)-DL-alpha-methylhomocysteine, at equimolar doses relative to DCVHcy, is not nephrotoxic. Agents that inhibit pyridoxal phosphate-dependent enzymes (DL-propargylglycine and aminooxyacetic acid) or renal organic anion transport (probenecid) protect against DCVHcy-induced nephrotoxicity. With kidney cytosol, DCVHcy or the analogue S-(2-benzothiazolyl)-L-homocysteine (BTHcy) is not metabolized to 2-ketobutyrate, but 2-mercaptobenzothiazole is a metabolite of BTHcy and the Vmax for its formation is enhanced by addition of 2-ketobutyrate. These results are consistent with a bioactivation mechanism for DCVHcy that involves enzymatic deamination followed by a nonenzymatic beta-elimination to produce two reactive intermediates--i.e., S-(1,2-dichlorovinyl)thiol and 2-keto-3-butenoic acid. The Km values for the N-acetylation of DCVCys and DCVHcy by kidney microsomal N-acetyltransferase are similar, but the rate of DCVCys N-acetylation is 4-fold greater than the rate measured with DCVHcy as the substrate. Thus, the remarkable nephrotoxic potency of DCVHcy compared with DCVCys may be attributable to intrarenal differences in activation and detoxication.
The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases (2013)

There currently exists relatively solid evidence supporting the use of KCa2 activators for ataxia. Genetic KCa2 channel suppression in deep cerebellar neurons induces ataxia, while KCa2 activators like 1-EBIO, SKA-31 and NS13001 improve motor deficits in mouse models of episodic ataxia (EA) and spinal cerebellar ataxia (SCA). Use of KCa2 activators for ataxia is further supported by a report that riluzole improves ataxia in a small clinical trial. Based on accumulating literature evidence, KCa2 activators further appear attractive for the treatment of alcohol dependence and withdrawal. Regarding Alzheimer's disease, Parkinson's disease and schizophrenia, further research, including long-term studies in disease relevant animal models, will be needed to determine whether KCa2 channels constitute valid targets and whether activators or inhibitors would be needed to positively affect disease outcomes.
Targeting and Imaging Signature Caveolar Molecules in Lungs (2009)

A major goal of molecular medicine is to target imaging agents or therapeutic compounds to a single organ. Targeting imaging agents to a single organ could facilitate the high-resolution, in vivo imaging of molecular events. In addition, genetic and acquired diseases primary to a single organ, such as cystic fibrosis, tuberculosis, lung cancer, pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome, could be specifically targeted in the lung. By targeting and concentrating imaging agents or therapeutics to the lungs, deleterious side effects can be avoided with greater efficacy at much lower dosages. Pathologic changes can be identified earlier and followed over time. In addition, therapeutics that have been abandoned due to toxicities may find renewed utility when coupled with specific targeting agents such as antibodies. To achieve these goals, distinct molecular signatures must be found for each organ or disease-state.
Inhibition of lipopolysaccharide-induced macrophage tumor necrosis factor-alpha synthesis by polymyxin B sulfate. (1993)

The antibiotic polymyxin B sulfate is a cationic polypeptide with a unique cyclical configuration and distinct cationic characteristics. In this investigation, polymyxin B was evaluated to determine its ability to prevent synthesis of lactic acid and tumor necrosis factor-alpha (TNF-alpha) by lipopolysaccharide-stimulated strain RAW 264.7 macrophage-like cell populations. In this context, gradient concentrations of polymyxin B were formulated in the presence of fixed concentrations of lipopolysaccharide fractions from Escherichia coli (B4:0111), E coli (J5), Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella minnesota, and S typhimurium (Re). Quantitation of TNF-alpha was established by the application of a tissue culture-based biological assay system, using the WEHI 164 clone 13 indicator cell line. Investigations also included evaluation of the ability of gradient concentrations of lipopolysaccharide fractions from E coli (B4:0111), E coli (J5), K pneumoniae, P aeruginosa, S minnesota, and S typhimurium (Re) to form a complex with polymyxin B. This was established through application of high-performance thin-layer chromatography techniques. On the basis of the known molecular characteristics of lipopolysaccharide, its lipid A-core subfractions, and polymyxin B, these results imply that cytoprotective properties of polymyxin B are attributable to direct interaction and subsequent complex formation. More specifically, the mechanism by which polymyxin B exerts affinity for lipopolysaccharide fractions is proposed to occur through attractive ionic interactions established between the cationic diaminobutyric acid residues of polymyxin B and the mono- or diphosphate group(s) of the lipid A-core moiety. It is highly probable that this molecular phenomenon is accompanied by hydrophobic interactions established between the terminal methyloctanoyl or methylheptanoyl groups of polymyxin B and the saturated carbon chains of the lipid A-core subfraction of lipopolysaccharide fractions.
Los futuros en el español medieval, sus orígenes y su evolución (1985)

En este número no se incluyeron resúmenes ni palabras clave.
Cemented and cementless fixation: results and techniques. (2006)

There are multiple reports of successful cemented and cementless total knee arthroplasty in the current literature. Although technically more demanding to implant, selected cementless designs, with nearly 20 years of follow-up, demonstrate near-equal success compared with cemented implants, the gold standard. Far more important than the decision to use a cemented or cementless implant is the use of precise technique, adequate balancing of the soft tissues, and proper overall alignment. Failure to achieve these basic principles can lead to early failure in any total knee replacement system.