gebhart/patrepeval huggingface dataset:
A graphics editor for labanotation (1976)

There is a need for a simple mechanized way to design, update and produce final copies of scores of Labanotation, a symbolic, graphical language for the recording of body movement used by choreographers, anthropologists, psychologists and therapists. This paper discusses the design and implementation of a machine-independent data structure for Labanotation and its application in an interactive storage, retrieval and editing system.
<i>TRAF1–C5</i> as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study (2007)

A common genetic variant at the TRAF1-C5 locus on chromosome 9 is associated with an increased risk of anti-CCP-positive rheumatoid arthritis.
Adaptive Anomaly Detection for SDN (2015)

In traditional approach, extracting important features for the application to analyze the anomaly detection problem, introduce significant overhead on the way of switch handling. Furthermore, high volumes of network traffic introduce notable issues that affect the performance and anomaly detection accuracy. Taking advantage of centralized control plane of Software Defined Networking (SDN), the task to handle the flow information is much more simplified programmatically. The accuracy of the measured flow statistic play important role in anomaly detection. While the use of sampling is capable to lessen the scalability problem of traffic monitoring, the insufficiency of sampled flow statistic may led to inaccurate detection rate of anomaly. In this paper, we propose an adaptive sampling strategy that is able to provide essential traffic statistics for accurate anomaly detection in SDN. Our sampling mechanism utilizes the clustering analysis, which is used to classify the attack in the network to determine the severity of monitored traffic. By manipulating the type of service of incoming packet together, these two important parameter formulate our sampling mechanism algorithm.
Analysis and Prediction of Constriction Resistance for Contact Between Rough Engineering Surfaces (2004)

The constriction resistance of a semi-infinite cylinder terminating in the frustum of a cone in a gaseous environment is analyzed numerically. The variation of constriction resistance with the ratio of contact radius to cylinder radius, the cone angle, and the gas-to-substrate thermal conductivity ratio is investigated. Nonlinear curve fitting is used to develop a comprehensive predictive correlation for the constriction resistance as a function of these parameters. The parameters are investigated over a wide range of values covering the range expected in practical applications. The correlation could be used in conjunction with an appropriate surface deformation model to predict the thermal contact resistance between rough metallic surfaces.
Effect of recombinant<i>Ganoderma lucidum</i>immunoregulatory protein on cyclophosphamide-induced leukopenia in mice (2013)

The aim of the study is to investigate the effect of recombinant Ganoderma lucidum immunoregulatory protein (rLZ-8) on mouse models of cyclophosphamide-induced leukopenia, which we have established with both single-phase and multi-phase administration methods. Treatment with rLZ-8 had a strong effect on both models of cyclophosphamide-induced leukopenia. In particular, it increased the number of neutrophils, lymphocytes and monocytes. rLZ-8 treatment also increased the percentage of CD4(+) T cells and the levels of secreted IL-3 and IL-4, which contributed to the cyclophosphamide-induced immune dysfunction and immune system imbalance. In conclusion, rLZ-8 treatment benefitted mice with cyclophosphamide-induced leukopenia by improving overall immune function and by specifically increasing the number of white blood cells.
Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6. (1995)

The tumour suppressor protein p53 normally functions as a tetramer in a defined conformational state. Mutations within p53 which contribute to cancer development frequently induce a conformational shift in the protein which correlates with loss of wild type growth suppressor functions. Both the cell encoded mdm2 protein and the human papillomavirus oncoprotein E6 can regulate p53 function and we have examined the interaction of these proteins with p53. The E6/p53 association is sensitive to conformational alterations in the p53 protein, although oligomerisation is not necessary for this interaction to occur. Analysis of C-terminal p53 truncations has indicated that the region between residues 327 and 347 may play a role in E6 binding. Since monomeric forms of p53 retain transcriptional and transformation suppressor activities, our results indicate that E6 targets p53 proteins which retain these wild type functions. Conversely, the interaction of p53 with mdm2 is not dependent on the conformation of the p53 protein but is significantly impaired by loss of quaternary structure. It is possible that mdm2 plays a role in mediating activities of p53 which, unlike transcriptional activation, depend on oligomerisation.
Immunomagnetic DNA Aptamer Assay (2001)

DNA aptamers, oligonucleotides with antibody-like binding properties, are easy to manufacture and modify. As a class of molecules, they represent the biggest revolution to immunodiagnostics since the discovery of monoclonal antibodies. To demonstrate that DNA aptamers are versatile reagents for use as in vitro diagnostic tools, we developed a hybrid immunobead assay based on a 5'-biotinylated DNA thrombin aptamer (5'-GGTTGGTGTGGTTGG-3') and an anti-thrombin antibody (EST-7). Our results show that the thrombin DNA aptamer is capable of binding to its target molecule under stringent in vitro assay conditions and at physiological concentrations. These findings also support the view that DNA aptamers have potential value as complementary reagents in diagnostic assays.
A Kalman filtering approach to short-time Fourier analysis (1986)

The problem of estimating time-varying harmonic components of a signal measured in noise is considered. The approach used is via state estimation. Two methods are proposed, one involving pole-placement of a state observer, the other using quadratic optimization techniques. The result is the development of a new class of filters, akin to recursive frequency-sampling filters, for inclusion in a parallel bank to produce sliding harmonic estimates. Kalman filtering theory is applied to effect the good performance in noise, and the class of filters is parameterized by the design tradeoff between noise rejection and convergence rate. These filters can be seen as generalizing the DFT.
Vehicle localization system based on IR-UWB for V2I applications (2013)

This paper investigates the implementation of Impulse Radio - Ultra Wide Band (IR-UWB) to locate vehicles in a Vehicle-to-Infrastructure (V2I) network for traffic management application. Localization techniques such as Time of Arrival (TOA), Time Difference of Arrival (TDOA) and Direction of Arrival (DOA) are proposed and tested aiming at better location accuracy. These techniques are evaluated in terms of position error between the actual vehicle's position and the estimated one. The proposed Matlab simulation scenarios consider different vehicle's locations going from one edge to the center then to the other edge of the network, at various ranges from three equally distant roadside units (RSUs) that extend from 1-20m. The evaluation shows that the optimum localization technique will be a hybrid one that combines TDOA and DOA techniques.
New Coupling Reactions of Some Acyl Chlorides with Samarium Diiodide in the Presence of Samarium: Carbinols from Three Acyl Units (2000)

A mixture of samarium(II) iodide and samarium can induce a coupling reaction of three molecules of alkanoyl halide to give trialkylcarbinols of 2-hydroxy-1,3-diones. When aliphatic, unbranched alkanoyl chlorides are used, this new coupling reaction provides trimeric products as the main reaction products. Tetrahydropyran (THP) proved superior as the solvent because no ring-opening and subsequent reaction with the alkanoyl halides was observed under the reaction conditions, unlike when THF was used.
Rapid and accurate characterisation of short tandem repeats by MALDI-TOF analysis of endonuclease cleaved RNA transcripts (2004)

We describe the application of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the characterisation of short tandem repeat (STR) sequences by the analysis of endonuclease cleaved RNA transcripts. Several simple bovine STR loci as well as interrupted and compound microsatellites were chosen as model loci to evaluate the capabilities of MALDI-TOF MS for STR analysis. In short, the described approach consists of a PCR amplification of the investigated STR sequence, which then is transcribed into RNA and cleaved by G-specific RNase T1. Base-specific cleavage of the transcript results in high informative fragment patterns from both the repetitive core sequence and the flanking region. Since sequence specificity from endonuclease cleavage is combined with the accuracy of MALDI-TOF measurements, this technique allows for fast and reliable determination of simple repeat lengths as well as for further characterisation of STR allele sequences, which is of high interest especially in more complex STR loci.
Correction: Slit2/Robo4 Signaling Modulates HIV-1 gp120-Induced Lymphatic Hyperpermeability (2012)

Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium.HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored.Using a primary human lymphatic endothelial cell model, we found that HIV-1 envelope protein gp120 induced lymphatic hyperpermeability by disturbing the normal function of Robo4, a novel regulator of endothelial permeability.HIV-1 gp120 induced fibronectin expression and integrin a 5 b 1 phosphorylation, which led to the complexing of these three proteins, and their subsequent interaction with Robo4 through its fibronectin type III repeats.Moreover, pretreatment with an active Nterminus fragment of Slit2, a Robo4 agonist, protected lymphatic endothelial cells from HIV-1 gp120-induced hyperpermeability by inhibiting c-Src kinase activation.Our results indicate that targeting Slit2/Robo4 signaling may protect the integrity of the lymphatic barrier and limit the dissemination of HIV in the host.
Contemporary Definitions and Classification of the Cardiomyopathies (2006)

Classifications of heart muscle diseases have proved to be exceedingly complex and in many respects contradictory. Indeed, the precise language used to describe these diseases is profoundly important. A new contemporary and rigorous classification of cardiomyopathies (with definitions) is proposed here. This reference document affords an important framework and measure of clarity to this heterogeneous group of diseases. Of particular note, the present classification scheme recognizes the rapid evolution of molecular genetics in cardiology, as well as the introduction of several recently described diseases, and is unique in that it incorporates ion channelopathies as a primary cardiomyopathy.
Über die Reaktion von <i>N</i>‐Brom‐imiden mit Disulfiden zu Sulfenimiden (1967)

Abstract Durch Reaktion von N ‐Brom‐imiden bzw. 3‐Brom‐hydantoinen mit Disulfiden werden zahlreiche Sulfenimide in hohen Ausbeuten erhalten. Der radikalische Reaktionsablauf wird diskutiert.
Seasonal Freeze Resistance of Rainbow Smelt (<i>Osmerus mordax</i>) Is Generated by Differential Expression of Glycerol‐3‐Phosphate Dehydrogenase, Phosphoenolpyruvate Carboxykinase, and Antifreeze Protein Genes (2006)

In winter, rainbow smelt (Osmerus mordax) accumulate glycerol and produce an antifreeze protein (AFP), which both contribute to freeze resistance. The role of differential gene expression in the seasonal pattern of these adaptations was investigated. First, cDNAs encoding smelt and Atlantic salmon (Salmo salar) phosphoenolpyruvate carboxykinase (PEPCK) and smelt glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were cloned so that all sequences required for expression analysis would be available. Using quantitative PCR, expression of beta actin in rainbow smelt liver was compared with that of GAPDH in order to determine its validity as a reference gene. Then, levels of glycerol-3-phosphate dehydrogenase (GPDH), PEPCK, and AFP relative to beta actin were measured in smelt liver over a fall-winter-spring interval. Levels of GPDH mRNA increased in the fall just before plasma glycerol accumulation, implying a driving role in glycerol synthesis. GPDH mRNA levels then declined during winter, well in advance of serum glycerol, suggesting the possibility of GPDH enzyme or glycerol conservation in smelt during the winter months. PEPCK mRNA levels rose in parallel with serum glycerol in the fall, consistent with an increasing requirement for amino acids as metabolic precursors, remained elevated for much of the winter, and then declined in advance of the decline in plasma glycerol. AFP mRNA was elevated at the onset of fall sampling in October and remained elevated until April, implying separate regulation from GPDH and PEPCK. Thus, winter freezing point depression in smelt appears to result from a seasonal cycle of GPDH gene expression, with an ensuing increase in the expression of PEPCK, and a similar but independent cycle of AFP gene expression.
An automated pipeline for analyzing medication event reports in clinical settings (2018)

We developed and evaluated an automated pipeline that could identify three attributes from the medication event reports and calculate the similarity scores between the reports based on the attributes. The pipeline is expected to improve the efficiency of analyzing the medication event reports and to learn from the reports in a timely manner.
Autocrine and Paracrine Roles for ATP and Serotonin in Mouse Taste Buds (2009)

Receptor (type II) taste bud cells secrete ATP during taste stimulation. In turn, ATP activates adjacent presynaptic (type III) cells to release serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE). The roles of these neurotransmitters in taste buds have not been fully elucidated. Here we tested whether ATP or 5-HT exert feedback onto receptor (type II) cells during taste stimulation. Our previous studies showed NE does not appear to act on adjacent taste bud cells, or at least on receptor cells. Our data show that 5-HT released from presynaptic (type III) cells provides negative paracrine feedback onto receptor cells by activating 5-HT(1A) receptors, inhibiting taste-evoked Ca(2+) mobilization in receptor cells, and reducing ATP secretion. The findings also demonstrate that ATP exerts positive autocrine feedback onto receptor (type II) cells by activating P2Y1 receptors and enhancing ATP secretion. These results begin to sort out how purinergic and aminergic transmitters function within the taste bud to modulate gustatory signaling in these peripheral sensory organs.
Management of produced water on offshore oil installations: a comparative assessment using flow analysis (2005)

Case studies provided by the UK Offshore Operators Association and its member companies Part of a wider collaborative study A Methodology for Measuring Sectoral Sustainable Development and its application to the UK oil &amp; gas sector’ The project is funded under the DTI’s Sustainable Technologies Initiative LINK Programme,
New polarized light microscope with precision universal compensator (1995)

A new type of polarized light microscope ('new pol-scope') for fast and orientation-independent measurement of birefringent fine structure has been developed. The design of the new pol-scope incorporates a precision universal compensator made from two liquid crystal variable retarders. A video camera and digital image processing system provide fast measurements of specimen anisotropy (retardance magnitude and azimuth) at all points of the image forming the field of view. The images document fine structural and molecular organization within a thin optical section of the specimen. The sensitivity of the current instrument is 0.1 nm of specimen retardance, measured with data gathered in 0.43 s at all 640 x 480 image points. Examples of birefringence measurements in biological (microtubule arrays) and industrial (magneto-optical disc substrate) specimens are presented.
<i>(Invited) </i>Ultrathin-Body Ge-on-Insulator MOSFET and TFET Technologies (2018)

CMOS and tunneling FETs (TFETs) utilizing Ge-On-Insulator (GOI) channels on Si substrates are expected as the promising device options for low-power integrated systems. In this paper, we present viable device and process technologies of GOI MOSFETs and TFETs on the Si CMOS platform. High compressive strain, favorable in p-MOSFET applications, is introduced in GOI films by optimizing the Ge condensation process and initial substrate structures, which is one of the most promising technologies to form ultrathin-body GOI p-MOSFETs. Also, source engineering in Ge layers to realize improved tunnel junctions with steep impurity profiles is developed for Ge/GOI TFET applications. In addition, impacts of Ge-based type-II hetero-structures such as Ge/strained-Si and Ge/ZnO on the TFET performance are studied. The electrical characteristics of GOI MOSFETs and TFETs are presented and analyzed from the viewpoints of applied strain, source junction properties and device structures.
Beta Cells Secrete Significant and Regulated Levels of Insulin for Long Periods when Seeded onto Acellular Micro-Scaffolds (2015)

The aim of this work is to obtain significant and regulated insulin secretion from human beta cells ex vivo. Long-term culture of human pancreatic islets and attempts at expanding human islet cells normally result in loss of beta-cell phenotype. We propose that to obtain proper ex vivo beta cell function, there is a need to develop three-dimensional structures that mimic the natural islet tissue microenvironment. We here describe the preparation of endocrine micro-pancreata (EMPs) that are made up of acellular organ-derived micro-scaffolds seeded with human intact or enzymatically dissociated islets. We show that EMPs constructed by seeding whole islets, freshly enzymatically-dissociated islets or even dissociated islets grown first in standard monolayer cultures express high levels of key beta-cell specific genes and secrete quantities of insulin per cell similar to freshly isolated human islets in a glucose-regulated manner for more than 3 months in vitro.
SINR, power efficiency, and theoretical system capacity of parallel interference cancellation (2001)

This paper analytically derives exact expressions for the SINR of the two-stage linear parallel interference cancellation (LPIC) and two-stage hard-decision parallel interference cancellation (HPIC) multiuser detectors in a synchronous, nonorthogonal, binary, CDMA communication system with deterministic short spreading sequences. We consider approximations to the SINR expressions that are justified in typical operating scenarios to obtain a more intuitive understanding of the SINR performance of the HPIC detector. We consider the case where a specific SINR requirement is given for each user in the system and derive expressions for the set of transmit powers necessary to meet this requirement when two-stage LPIC or HPIC detection is used. We also derive expressions for a measure of the theoretical system capacity using LPIC and HPIC detection, defined as the maximum number of users possible in a system with finite available transmit power. Numerical results are presented that compare the HPIC and LPIC detectors to the hard-decision successive interference cancellation (SIC) detector and matched filter (MF) detector. Our results suggest that HPIC detection may offer the best SINR and power efficiency performance when the number of users in the system is low to moderate and that SIC detection may offer superior performance when the number of users in the system is large.
Diagnosis of interconnects and FPICs using a structured walking-1 approach (2002)

This paper presents a generalized new approach for testing interconnects (for boundary scan architectures) as well as field programmable interconnect chips (FPICs). The proposed structural test method explicitly avoids aliasing and confounding and as applicable to dense as well as sparse layouts. The proposed method is applicable to both one-step and two-step test generation and diagnosis. Two algorithms with an execution complexity of O(n/sup 2/), where n is the number of nets in the interconnect, are given. Simulation results for benchmark and randomly generated layouts show a substantial reduction in the number of tests using the proposed approaches compared with previous approaches. The applicability of the proposed approach to FPICs is discussed and evaluated by simulation.
Reduced production of interleukin 2 and interferongamma and enhanced helper activity for IgG synthesis by cloned CD4<sup>+</sup> T cells from patients with AIDS (1987)

Abstract Purified T lymphocytes (E rosetting cells) isolated from peripheral blood (PB) of four patients with acquired immune deficiency syndrome (AIDS) were cloned under culture conditions (phytohemagglutinin plus interleukin 2) which allow clonal expansion of most T lymphocytes. A total number of 101 T cell clones (37 CD4 + and 64 CD8 + ) from PB of AIDS patients and of 188 T cell clones (115 CD4 + and 73 CD8 + ) from PB of four normal controls were obtained and tested for their helper function as well as for their capacity to release lymphokines. Unstimulated CD4 + TCC from patients with AIDS showed enhanced helper function for IgG synthesis in vitro in both autologous and normal allogeneic B cells in comparison to clonable CD4 + T cells of normal donors. Such activity was further potentiated by addition to the cell cultures of anti‐CD3 monoclonal antibody. The majority of CD4 + T cell clones from AIDS patients showed a reduced ability to produce interleukin 2 and interferon‐γ in response to activation with phytohemagglutinin. However, most of them released greater amounts of soluble factor(s) able to promote B cell proliferation of anti‐IgM‐activated normal B cells and to induce the differentiation of normal B lymphocytes into IgG‐secreting cells. These data demonstrate that most surviving CD4 + T cells in PB of patients with AIDS belong to a T cell subset producing B cell growth and differentiation factors, which may contribute to the B cell hyperactivation seen in AIDS patients.
Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases (2013)

All the newly synthesized DCP-LA-phospholipids serve as a PKC activator and of them diDCP-LA-PE alone has the potential to activate the atypical PKC isozymes PKCι and -ζ. diDCP-LA-PE and diDCP-LA-PI serve as an inhibitor for PP1 and PTP1B, diDCP-LA-PS as a PTP1B inhibitor, diDCP-LA-PI as a PP2A enhancer, and diDCP-LA-PC as a PTP1B enhancer.
A manufacturable complementary GaAs process (2002)

A self-aligned complementary GaAs heterostructure FET process has been established for low power, high-speed digital circuits. The devices are fabricated on four-inch MBE epitaxial wafers consisting of AlGaAs/InGaAs epilayers grown on LEC GaAs substrates. The process uses twelve lithographic steps including two levels of interconnect metal. Typical transconductances of 250 mS/mm and 60 mS/mm are achieved on 1/spl times/10 /spl mu/m N-channel and P-channel devices, respectively. Twenty-three stage unloaded complementary ring oscillators consisting of 1/spl times/10 /spl mu/m N- and P-FETs show propagation delay of 190 ps and speed-power product of 7.5 fJ or 0.35 /spl mu/W/MHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>