gebhart/patrepeval huggingface dataset:
Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity (2010)

Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism with multiple isozymes often expressed in different eukaryotic cellular compartments. ACC-made malonyl-CoA serves as a precursor for fatty acids; it also regulates fatty acid oxidation and feeding behavior in animals. ACC provides an important target for new drugs to treat human diseases. We have developed an inexpensive nonradioactive high-throughput screening system to identify new ACC inhibitors. The screen uses yeast gene-replacement strains depending for growth on cloned human ACC1 and ACC2. In "proof of concept" experiments, growth of such strains was inhibited by compounds known to target human ACCs. The screen is sensitive and robust. Medium-size chemical libraries yielded new specific inhibitors of human ACC2. The target of the best of these inhibitors was confirmed with in vitro enzymatic assays. This compound is a new drug chemotype inhibiting human ACC2 with 2.8 muM IC(50) and having no effect on human ACC1 at 100 muM.
Polarized Surface Enhanced Raman and Absorbance Spectra of Aligned Silver Nanorod Arrays (2006)

Polarized surface-enhanced Raman scattering (SERS) and UV-vis absorbance spectra were measured for a nonplanar Ag nanorod array substrate prepared by oblique angle vapor deposition. The anisotropy of the SERS polarization was shown to differ from that of the polarized UV-vis absorbance. The maximum SERS intensity was observed in the polarization direction perpendicular to the long axis of the Ag nanorods, while the UV-vis absorbance was strongly polarized along the direction of the long axis of the nanorod array. Analysis of the polarization data showed that molecular orientation was not the cause of the anisotropic SERS scattering. Rather, the SERS anisotropy was primarily attributed to the lateral arrangement of the three-dimensional tilted nanorod lattice in which highly localized plasmon modes are created by strong electromagnetic coupling between adjacent metallic nanorods.
<title>Mechanism of laser-induced stress relaxation in cartilage</title> (1997)

The paper presents theoretical and experimental results allowing to discuss and understand the mechanism of stress relaxation and reshaping of cartilage under laser radiation. A carbon dioxide and a Holmium laser was used for treatment of rabbits and human cartilage. We measured temperature, stress, amplitude of oscillation by free and forced vibration, internal friction, and light scattering in the course of laser irradiation. Using experimental data and theoretical modeling of heat and mass transfer in cartilaginous tissue we estimated the values of transformation heat, diffusion coefficients and energy activation for water movement.
Electro-Optic Sampling In Gallium Arsenide (1988)

Electro-optic sampling uses short optical pulses to measure high-speed electrical waveforms propagating in electro-optic crystals. Since GaAs is electro-optic, a perfect application of this technique is the noninvasive probing of signals propagating in devices and circuits made in this and related compound semiconductors. Principles, limitations and applications to high-speed circuit characterization will be discussed.
Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T b gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa. (2002)

The results confirmed the efficiency of the classic wb-CATT to detect sleeping sickness patients. The micro-CATT method can be used for human African trypanosomiasis surveillance if the test is performed on the same day as the blood collection, or if samples are stored at 4 degrees C. Otherwise, micro-CATT can be used when absolute sensitivity is not required. wb-LATEX should only be used for high-specificity screening.
Non-Compaction Cardiomyopathy in an Adult with Hereditary Spherocytosis (2006)

A 23-year old male (199 cm, 88 kg) presented muscular weakness due to skeletal myopathy and symptoms of heart failure NYHA functional class II. Total creatine kinase was increased up to 830 U/l, but troponin was negative. Prior episodes of intermittent atrial fibrillation were reported and 6 years ago splenectomy was performed due to hereditary spherocytosis. Cardiac magnetic resonance imaging revealed the spongy appearance of non-compacted left ventricular myocardium. This impaired fetal morphogenesis occurred predominantly in the apical to midventricular anterior, lateral and inferior segments. Non-compaction cardiomyopathy was initially described in paediatric patients. Occasional associations with other congenital disorders are known, e.g., Barth syndrome, which is an X-linked disease characterized by cardio-skeletal myopathy of variable severity and neutropenia. To our knowledge, combined occurrence of non-compaction cardiomyopathy, skeletal myopathy and hereditary spherocytosis has not previously been reported.
Regulation of low density lipoprotein metabolism by 26‐hydroxycholesterol in human fibroblasts (1987)

Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.
Use of the RS decoder as an RS encoder for two-way digital communications and storage systems (1994)

It is shown that any Reed-Solomon (RS) decoder which corrects both errors and erasures also can be used as an encoder for the RS code. This technique eliminates the need of a separate subsystem, namely the RS encoder in either two-way digital communication systems or storage devices which use RS encoding and decoding. As a consequence a single RS decoder chip which corrects both errors and erasures can be mass-manufactured for use in all two-way communication systems and storage devices such as a digital video-cassette recorder (VCR) or a write-once, read-many, (WORM) optical disk drive.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel Core−Shell-Structured Li[(Ni<sub>0.8</sub>Co<sub>0.2</sub>)<sub>0.8</sub>(Ni<sub>0.5</sub>Mn<sub>0.5</sub>)<sub>0.2</sub>]O<sub>2</sub> via Coprecipitation as Positive Electrode Material for Lithium Secondary Batteries (2006)

We have successfully synthesized a spherical core-shell structure based on Li[(Ni0.8Co0.2)0.8(Ni0.5Mn0.5)0.2]O2 via a coprecipitation route. According to the careful examination by scanning electron microscopy (SEM), transmission electron microscopy energy-dispersive spectroscopy (TEM-EDS), and X-ray diffraction (XRD), it was found that the core-shell particle consisted of Li[Ni0.8Co0.2]O2 as the core and Li[Ni0.5Mn0.5]O2 as the shell, of which the thickness was estimated to be 1 to approximately 1.5 microm. Both the core and shell were dense as confirmed by SEM. Though the core-shell-structured Li[(Ni0.8Co0.2)0.8(Ni0.5Mn0.5)0.2]O2 delivered a slightly reduced initial discharge capacity, the capacity retention and thermal stability were significantly improved relative to those of the Li[Ni0.8Co0.2]O2 electrode without the Li[Ni0.5Mn0.5]O2 shell. The carbon/Li[Ni0.8Co0.2]O2 pouch cell underwent an explosive ignition during the nail penetration test, whereas the carbon/Li[(Ni0.8Co0.2)0.8(Ni0.5Mn0.5)0.2]O2 cell remained stable, demonstrating the superior thermal stability of the core-shell electrode. As a new positive electrode material, the core-shell-structured Li[(Ni0.8Co0.2)0.8(Ni0.5Mn0.5)0.2]O2 is a significant breakthrough in the development of high-capacity lithium secondary batteries.
Cyto‐ and hemocompatibility of a biodegradable 3D‐scaffold material designed for medical applications (2009)

In this study, the polyester urethane Degrapol (DP) was explored for medical applications. Electrospun DP-fiber fleeces were characterized with regard to fiber morphology, swelling, and interconnectivity of interfiber spaces. Moreover, DP was assayed for cell proliferation and hemocompatibility being a prerequisite to any further in vivo application. It was shown that DP-fiber fleeces produced at different humidity while spinning affects interconnectivity of interfiber spaces, such that the higher the humidity the looser the resulting fiber fleeces. When the spinning target was cooled with dry ice, the resulting DP-fibers remained less fused to each other. However, permeability for fluorescent beads was not significantly increased. Fibroblast adhesion and proliferation occurred in a comparable manner on native as well as on fibronectin or collagen I adsorbed DP-fiber fleeces. On DP-surfaces fibroblasts proliferated equally well as compared with glass or PLGA surfaces or DP-surfaces adsorbed with fibronectin or collagen I. In contrast, human umbilical vein endothelial cells proliferated only after adsorption of DP-surfaces with fibronectin or collagen I, indicating that different cell types respond differently to DP-surfaces. Furthermore, hemocompatibility of DP-surfaces was found to be similar or better to PLGA or stainless steel, both medically used materials. These experiments indicate that DP-fiber fleeces or surfaces might be useful for tissue engineering.
High speed electro-optical cavity dumping of mode-locked laser oscillators (2005)

High speed electro-optical cavity dumping is demonstrated with diode-pumped mode-locked laser oscillators, namely a femtosecond Yb:glass and a picosecond Nd:YVO4 oscillator. Repetition frequencies exceeding 1MHz are obtained with pulse energies of more than 300nJ /1 microJ. Being compact and easy to operate light sources, these laser systems open up various scientific and industrial applications.
Existence of three regulatory regions each containing a highly conserved motif in the promoter of plastid‐encoded RNA polymerase gene (<i>rpoB</i>) (1997)

The plastid gene rpoB encodes a plastid-specific, DNA-dependent RNA polymerase. A study of a barley mutant, albostrians, indicated that rpoB itself is transcribed by a nuclear-encoded RNA polymerase. However, the molecular nature of the nuclear-encoded RNA polymerase and mechanisms of the transcriptional regulation of rpoB expression have not been elucidated. Using an in vivo transient assay system for gene expression in plastids, the 5'-flanking region of rpoB from Arabidopsis thaliana in plastids of cultured BY-2 tobacco cells was analyzed. A series of deletion analyses of the 5'-flanking region indicated that there were two positive and one negative regulatory regions for rpoB expression. Comparison of the 5'-flanking sequences of rpoB among several plant species revealed the existence of three conserved motifs in these regions.
A low-cost and shielding-free ultra-low-field brain MRI scanner (2021)

Magnetic resonance imaging is a key diagnostic tool in modern healthcare, yet it can be cost-prohibitive given the high installation, maintenance and operation costs of the machinery. There are approximately seven scanners per million inhabitants and over 90% are concentrated in high-income countries. We describe an ultra-low-field brain MRI scanner that operates using a standard AC power outlet and is low cost to build. Using a permanent 0.055 Tesla Samarium-cobalt magnet and deep learning for cancellation of electromagnetic interference, it requires neither magnetic nor radiofrequency shielding cages. The scanner is compact, mobile, and acoustically quiet during scanning. We implement four standard clinical neuroimaging protocols (T1- and T2-weighted, fluid-attenuated inversion recovery like, and diffusion-weighted imaging) on this system, and demonstrate preliminary feasibility in diagnosing brain tumor and stroke. Such technology has the potential to meet clinical needs at point of care or in low and middle income countries.
Communities of practice: bridging technology and knowledge assessment (2000)

Introduces an assessment model being developed around a knowledge initiative in Pepperdine University’s Educational Technology Doctoral program ( http://moon.pepperdine.edu/gsep/programs/ET ). The knowledge initiative involves the implementation of group memory technology, developed by Intraspect Software ( http://www.intraspect.com ), in an attempt to cultivate a community of practice in the program. The assessment model looks for indicators of communities of practice and mines for usage patterns called “knowledge transactions”, as forms of measures.
Revisiting the method of cumulants for the analysis of dynamic light-scattering data (2001)

The method of cumulants is a standard technique used to analyze dynamic light-scattering data measured for polydisperse samples. These data, from an intensity-intensity autocorrelation function of the scattered light, can be described in terms of a distribution of decay rates. The method of cumulants provides information about the cumulants and the moments of this distribution. However, the method does not permit independent determination of the long-time baseline of the intensity correlation function and can lead to inconsistent results when different numbers of data points are included in the fit. The method is reformulated in terms of the moments about the mean to permit more robust and satisfactory fits. The different versions of the method are compared by analysis of the data for polydisperse-vesicle samples.
Word-Embedding based Content Features for Automated Oral Proficiency Scoring (2018)

In this study, we develop content features for an automated scoring system of non-native English speakers’ spontaneous speech. The features calculate the lexical similarity between the question text and the ASR word hypothesis of the spoken response, based on traditional word vector models or word embeddings. The proposed features do not require any sample training responses for each question, and this is a strong advantage since collecting question-specific data is an expensive task, and sometimes even impossible due to concerns about question exposure. We explore the impact of these new features on the automated scoring of two different question types: (a) providing opinions on familiar topics and (b) answering a question about a stimulus material. The proposed features showed statistically significant correlations with the oral proficiency scores, and the combination of new features with the speech-driven features achieved a small but significant further improvement for the latter question type. Further analyses suggested that the new features were effective in assigning more accurate scores for responses with serious content issues.
Substrate Specificity and Signal Transduction Pathways in the Glucose-Specific Enzyme II (EII <sup>Glc</sup> ) Component of the <i>Escherichia coli</i> Phosphotransferase System (2000)

Escherichia coli adapted to glucose-limited chemostats contained mutations in ptsG resulting in V12G, V12F, and G13C substitutions in glucose-specific enzyme II (EII(Glc)) and resulting in increased transport of glucose and methyl-alpha-glucoside. The mutations also resulted in faster growth on mannose and glucosamine in a PtsG-dependent manner. By use of enhanced growth on glucosamine for selection, four further sites were identified where substitutions caused broadened substrate specificity (G176D, A288V, G320S, and P384R). The altered amino acids include residues previously identified as changing the uptake of ribose, fructose, and mannitol. The mutations belonged to two classes. First, at two sites, changes affected transmembrane residues (A288V and G320S), probably altering sugar selectivity directly. More remarkably, the five other specificity mutations affected residues unlikely to be in transmembrane segments and were additionally associated with increased ptsG transcription in the absence of glucose. Increased expression of wild-type EII(Glc) was not by itself sufficient for growth with other sugars. A model is proposed in which the protein conformation determining sugar accessibility is linked to transcriptional signal transduction in EII(Glc). The conformation of EII(Glc) elicited by either glucose transport in the wild-type protein or permanently altered conformation in the second category of mutants results in altered signal transduction and interaction with a regulator, probably Mlc, controlling the transcription of pts genes.
Contrast-enhanced 3D MR DSA of the carotid artery bifurcation: preliminary study of comparison with unenhanced 2D and 3D time-of-flight MR angiography. (1998)

Three-dimensional MR DSA improves the delineation of carotid arterial stenosis by virtually eliminating saturation effects and reducing intravoxel dephasing. Surface morphology and nearly occluded vessels ("string sign") were easily identified. Confidence in identifying carotid arterial occlusions was also very high with this technique.
Query containment in entity SQL (2013)

We describe a software architecture we have developed for a constructive containment checker of Entity SQL queries defined over extended ER schemas expressed in Microsoft's Entity Data Model. Our application of interest is compilation of object-to-relational mappings for Microsoft's ADO.NET Entity Framework, which has been shipping since 2007. The supported language includes several features which have been individually addressed in the past but, to the best of our knowledge, they have not been addressed all at once before. Moreover, when embarking on an implementation, we found no guidance in the literature on how to modularize the software or apply published algorithms to a commercially-supported language. This paper reports on our experience in addressing these real-world challenges.
Synthesis of Some 2(3<i>H</i>)‐Benzoxazolone Derivatives and their <i>in‐vitro</i> Effects on Human Leukocyte Myeloperoxidase Activity (2005)

Myeloperoxidase (MPO), a heme protein expressed by polymorphonuclear leukocytes, generates potent oxidants which are proposed to contribute to tissue damage during inflammation and certain pathogenesis such as neurodegenerative disorders. In this study, twenty omega-[2-oxo-3H-benzoxazol-3-yl]-N-phenylacetamide and propionamide derivatives having substituents of different lipophilic and electronic nature on the N-phenyl ring were synthesized to evaluate the inhibitory effects on in vitro leukocyte MPO chlorinating activity. The most active compounds in the series were the derivatives bearing 2-methyl and 4-nitro substituent on the N-phenyl ring.
Probabilistic question answering on the Web (2005)

Abstract Web‐based search engines such as Google and NorthernLight return documents that are relevant to a user query, not answers to user questions. We have developed an architecture that augments existing search engines so that they support natural language question answering. The process entails five steps: query modulation, document retrieval, passage extraction, phrase extraction, and answer ranking. In this article, we describe some probabilistic approaches to the last three of these stages. We show how our techniques apply to a number of existing search engines, and we also present results contrasting three different methods for question answering. Our algorithm, probabilistic phrase reranking (PPR), uses proximity and question type features and achieves a total reciprocal document rank of .20 on the TREC8 corpus. Our techniques have been implemented as a Web‐accessible system, called NSIR.
Visual Analysis of College Sports Performance Based on Multimodal Knowledge Graph Optimization Neural Network (2022)

In this paper, through data analysis of multimodal knowledge graph optimized neural network and visual analysis of college students' sports performance, we use huge graph, a graph database supporting distributed storage, to store domain knowledge in the form of the knowledge graph, use Spring Boot to build a server-side framework, use Vue framework combined with vis.js to visualize relational network graphs, and design and implement a knowledge-oriented. This paper proposes a visual analytics system based on the theory of visual analytics. Based on the idea of visual analytics, this paper presents a visual analytics framework combining predictive models. This framework combines the automated analysis capability of predictive models with interactive visualization as a new idea to explore the visual analysis of student behavior and performance changes. Using relevant predictive algorithms in machine learning, corresponding models are built to refine the importance of features for visual analysis and correlate behavioral data with achievement data. In this process, multiple prediction algorithms are used to build prediction models. The model effects are analyzed and compared to select the optimal model for use in the visual analytics framework. The graphical analytic view is integrated. EduRedar, an optical analytical system for sports data based on the performance prediction model, is designed and implemented to support multidimensional and multiangle data analysis and visualize the changes in college students' sports and performance based on accurate campus exercise data.
Exploring the Hydrolysis of Sucrose by Invertase Using Nuclear Magnetic Resonance Spectroscopy: A Flexible Package of Kinetic Experiments (2014)

Nuclear magnetic resonance spectroscopy (NMR) is a viable alternative to current methods to introduce enzymatic reactions and monitor kinetics in the undergraduate curriculum. Using NMR to observe the invertase-catalyzed conversion of sucrose to fructose and glucose, one can gather information about the order of the reaction, as well as the maximum rate (vmax) and the Michaelis constant (KM). Kinetic parameters determined in this NMR study are comparable to the results obtained through polarimetry, the method often used to study this reaction at the undergraduate level. The breadth of information that NMR provides can give students a better understanding of the changes in reactant and product concentration over time, giving a visual connection to the rate law they derive.
A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease (1998)

Formation of beta-amyloid and neurofibrillary tangles in the brain due to genetic or other factors is the most frequent cause of Alzheimer's disease. In addition, marked reduction of certain brain neuropeptide levels is a consistent finding in patients with Alzheimer's disease, together with the deterioration of cholinergic neurons. Currently, there is great demand for the development of new drugs to improve memory deficits or to delay the neurodegenerative process in conditions such as Alzheimer's disease. In this report, the pharmacological actions of JTP-4819, a novel specific prolyl endopeptidase (PEP) inhibitor devised for the treatment of Alzheimer's disease, are reviewed with respect to its effects on PEP activity, neuropeptidergic and cholinergic neurons, and memory-related behavior in rats. We also discuss the possible beneficial effect of JTP-4819 on beta-amyloid metabolism and its potential neuroprotective properties.