gebhart/patrepeval huggingface dataset:
Linking Named Entities to Any Database (2012)

Existing techniques for disambiguating named entities in text mostly focus on Wikipedia as a target catalog of entities. Yet for many types of entities, such as restaurants and cult movies, relational databases exist that contain far more extensive information than Wikipedia. This paper introduces a new task, called Open-Database Named-Entity Disambiguation (Open-DB NED), in which a system must be able to resolve named entities to symbols in an arbitrary database, without requiring labeled data for each new database. We introduce two techniques for Open-DB NED, one based on distant supervision and the other based on domain adaptation. In experiments on two domains, one with poor coverage by Wikipedia and the other with near-perfect coverage, our Open-DB NED strategies outperform a state-of-the-art Wikipedia NED system by over 25 % in accuracy.
Analysis of Nordex N43/600 Wind turbine (2009)

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Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha, tumor necrosis factor-alpha, and interleukin-6. (1993)

With evidence that several proteins inhibit insulin-like growth factor (IGF) activity, we evaluated whether cytokines, which are elevated in many catabolic states, also affect IGF-1-mediated proteoglycan synthesis. Cartilage from hypophysectomized rats was exposed to the cytokines interleukin-1 alpha (IL-1 alpha), tumor necrosis factor-alpha (TNF-alpha) or interleukin-6 (IL-6) in the presence or absence of IGF-1. IL-1 alpha inhibited IGF-1-stimulated proteoglycan (PG) synthesis > 95% at 20 ng/ml (p < 0.01). TNF-alpha and IL-6 caused a maximum inhibition of 56 and 54%, respectively, both at 200 ng/ml. Only in the absence of IGF-1 did IL-1 alpha inhibit PG synthesis below unstimulated levels, suggesting that although IL-1 alpha can directly inhibit PG synthesis, IL-1 alpha, TNF-alpha, TNF-alpha, and IL-6 each promotes cartilage loss also by inhibiting IGF-1-mediated anabolism.
Characterization of a new electron cyclotron resonance source working with permanent magnets (1991)

Most electron cyclotron resonance (ECR) sources available today are working with electromagnets. A new source, developed for etch applications, is supplied with permanent magnets. This leads to strong short-range magnetic fields and the ECR condition is fulfilled on a ring near the chamber wall. Having the maximum electric field strength of the 2.45 GHz along this ring in the microwave radiator leads to efficient plasma production. The principle source characteristics are demonstrated with oxygen plasmas. At low pressure (some 10−4—some 10−3 mbar) and moderate microwave power (100–500 W) the plasma burns as a ring plasma. Increasing pressure and/or microwave power over the above mentioned values leads to a ‘‘bulk’’-type plasma. The change from ‘‘ring’’-type to bulk-type plasma occurs discontinuously and is connected (a) with a discontinuity in the run of the reflected power and (b) with a sudden change in the relative ion flux densities of different ionic fragments measured by mass spectrometry. Absolute ion densities up to 5×1010 cm−3 have been found by Langmuir probe measurements in a bulk plasma at a pressure of 1×10−3 mbar. Anisotropic etching of polysilicon over SiO2 was performed in the ring mode with pure Cl2 as feed gas and applying a radio-frequency (rf) extraction to the ECR plasma. Low damage etching was achieved due to the low direct-current (dc)-bias voltage of 150–200 V with very good anisotropy. The poly-Si etchrate was 85 nm/min with a selectivity of 18:1 to SiO2 and a uniformity of ±7.5% over 200 mm wafers.
Effect of growth hormone and resistance exercise on muscle growth in young men (1992)

The purpose of this study was to determine whether growth hormone (GH) administration enhances the muscle anabolism associated with heavy-resistance exercise. Sixteen men (21-34 yr) were assigned randomly to a resistance training plus GH group (n = 7) or to a resistance training plus placebo group (n = 9). For 12 wk, both groups trained all major muscle groups in an identical fashion while receiving 40 micrograms recombinant human GH.kg-1.day-1 or placebo. Fat-free mass (FFM) and total body water increased (P less than 0.05) in both groups but more (P less than 0.01) in the GH recipients. Whole body protein synthesis rate increased more (P less than 0.03), and whole body protein balance was greater (P = 0.01) in the GH-treated group, but quadriceps muscle protein synthesis rate, torso and limb circumferences, and muscle strength did not increase more in the GH-treated group. In the young men studied, resistance exercise with or without GH resulted in similar increments in muscle size, strength, and muscle protein synthesis, indicating that 1) the larger increase in FFM with GH treatment was probably due to an increase in lean tissue other than skeletal muscle and 2) resistance training supplemented with GH did not further enhance muscle anabolism and function.
Standalone Screen Selection Using Performance Mastercurves (2006)

Abstract The performance of stand alone screens can be predicted by developing master curves for individual screens based on the screen opening pore size and an effective formation particle size factor.Screen mesh designs and pore structures have unique performance curves which can be used with particle size analysis from whole or sidewall cores to aid in the selection of screens which will meet performance criteria for solids production and flow capacity for a specific wellbore.The paper describes the procedures for developing the performance master curves for screen laminates.Examples are given illustrating the predictive data for solids production and flow capacity for a series of well core samples.
Past Temperatures Directly from the Greenland Ice Sheet (1998)

A Monte Carlo inverse method has been used on the temperature profiles measured down through the Greenland Ice Core Project (GRIP) borehole, at the summit of the Greenland Ice Sheet, and the Dye 3 borehole 865 kilometers farther south. The result is a 50, 000-year-long temperature history at GRIP and a 7000-year history at Dye 3. The Last Glacial Maximum, the Climatic Optimum, the Medieval Warmth, the Little Ice Age, and a warm period at 1930 A.D. are resolved from the GRIP reconstruction with the amplitudes -23 kelvin, +2.5 kelvin, +1 kelvin, -1 kelvin, and +0.5 kelvin, respectively. The Dye 3 temperature is similar to the GRIP history but has an amplitude 1.5 times larger, indicating higher climatic variability there. The calculated terrestrial heat flow density from the GRIP inversion is 51.3 milliwatts per square meter.
Data on multimerization efficiency for short linear DNA templates and phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase (2020)

This article reports experimental data related to the research article entitled "Prevention of DNA multimerization using phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase" (R.R. Garafutdinov, A.R. Sakhabutdinova, M.S. Kupryushkin, D.V. Pyshnyi, 2020) [1]. Here, multimerization efficiency in terms of Tt (time-to-threshold) values obtained for artificial DNA templates with the different nucleotide sequences during isothermal amplification with Bst exo- DNA polymerase is given. Data on the influence of phosphoryl guanidine primers (PGO) on multimerization for the LTc template which has shown high efficiency of multimerization are presented as well.
Gambit: An Interactive Database Design Tool for Data Structures, Integrity Constraints, and Transactions (1985)

The design of a database is a rather complex and dynamic process that requires comprehensive knowledge and experience. There exist many manual design tools and techniques, but the step from a schema to an implementation is still a delicate subject. The interactive database design tool Gambit supports the whole process in an optimal way. It is based on an extended relational-entity relationship model. The designer is assisted in outlining and describing data structures and consistency preserving update transactions. The constraints are formulated using the database programming language Modula/R which is based upon first-order predicate calculus. The update transactions are generated automatically as Modula/R programs and include all defined integrity constraints. They are collected in so-called data modules that represent the only interface to the database apart from read operations. The prototype facility of Gambit allows the designer to test the design of the database. The results can be used as feedback leading to an improvement of the conceptual schema and the transactions.
Wavelength-scanning calibration of detection efficiency of single photon detectors by direct comparison with a photodiode (2016)

We present a practical calibration method of the detection efficiency (DE) of single photon detectors (SPDs) in a wide wavelength range from 480 nm to 840 nm. The setup consists of a GaN laser diode emitting a broadband luminescence, a tunable bandpass filter, a beam splitter, and a switched integrating amplifier which can measure the photocurrent down to the 100 fA level. The SPD under test with a fibre-coupled beam input is directly compared with a reference photodiode without using any calibrated attenuator. The relative standard uncertainty of the DE of the SPD is evaluated to be from 0.8% to 2.2% varying with wavelength (k = 1).
DNA-induced increase in the .alpha.-helical content of C/EBP and GCN4 (1991)

Leucine zipper proteins comprise a recently identified class of DNA binding proteins that contain a bipartite structural motif consisting of a "leucine zipper" dimerization domain and a segment rich in basic residues responsible for DNA interaction. Protein fragments encompassing the zipper plus basic region domains (bZip) have previously been used to determine the conformational and dynamic properties of this motif. In the absence of DNA, the coiled-coil portion is alpha-helical and dimeric, whereas the basic region is flexible and partially disordered. Addition of DNA containing a specific recognition sequence induces a fully helical conformation in the basic regions of these fragments. However, the question remained whether the same conformational change would be observed in native bZip proteins where the basic regions might be stabilized in an alpha-helical conformation even in the absence of DNA, through interactions with portions of the protein not included in the bZip motif. We have now examined the DNA-induced conformational transition for an intact bZip protein, GCN4, and for the bZip fragment of C/EBP with two enhancers that are differentially symmetric. Our results are consistent with the induced helical fork model wherein the basic regions are largely flexible in the absence of DNA and become fully helical in the presence of the specific DNA recognition sequence.
Data mining: Going beyond traditional statistics (2006)

Abstract The authors provide an overview of data mining, giving special attention to the relationship between data mining and statistics to unravel some misunderstandings about the two techniques.
Incorporation of labelled glycine into reduced glutathione of intact human erythrocytes by enzyme-catalysed exchange. A nuclear-magnetic-resonance study (1982)

1H, 2H and 15N n.m.r. spectroscopy was used to monitor the incorporation of free glycine into the glycine residue of reduced glutathione (GSH) in suspensions of intact human erythrocytes. The following results were obtained. (i) By using 1H spin-echo n.m.r. the exchange reaction between [2H5]glycine and the protonated glycine residue of GSH was studied at various [2H5]glycine concentrations, thus enabling the calculation of an apparent Michaelis constant (Km) and maximal velocity (Vmax.) for the process. (ii) The reaction is catalysed by glutathione synthetase and proceeds most rapidly in the absence of glucose, which is the main physiological energy source of the erythrocyte. (iii) 15N n.m.r. spectroscopy, with a one-pulse sequence, and 2H n.m.r. spectroscopy, with an inversion recovery method, enabled demonstration of the incorporation of labelled glycine into an intra-erythrocyte peptide, consistent with incorporation into GSH. (iv) The exchange reaction, although inhibited by glucose, appeared not to be dependent on low ATP or 2,3-bisphosphoglycerate concentrations.
The incidence of systemic lupus erythematosus in baltimore, maryland, 1970–1977 (1985)

The incidence of systemic lupus erythematosus, based on first hospital discharge diagnosis, in Baltimore, Maryland for the years 1970 through 1977 was determined for individual sex-race groups and the total population. Age-specific incidence rates were consistently highest among black females and lowest among white males: rates for white females exceeded those for black males through age 54, but then declined for ages greater than or equal to 55. Mean age at diagnosis was significantly lower for black females versus white females (35.5 versus 41.7 years, P = 0.005) and for all females versus all males (37.2 versus 44.2 years, P = 0.012). There were no temporal trends noted in yearly age-adjusted incidence rates during the 8-year study period. The overall population incidence of systemic lupus erythematosus was 4.6 per 100,000 per year, representing a twofold increase over a comparable study done in New York City 15 years ago.
New developments in occupational asthma (1992)

Recent developments in occupational asthma are reviewed. There are now three independent estimates of the incidence of occupational asthma in the general working population, which all identify the same high risk occupational groups (particularly those exposed to isocyanates and flour or wheat). The incidence of occupational asthma principally depends on the agent and level of exposure. The property of a small molecular weight chemical to bind to and alter the structure of body proteins seems important. Smoking both increases the number of workers developing specific IgE to occupational agents, and the number developing occupational asthma. The relation between increased non-specific bronchial responsiveness and occupational asthma is reviewed. Occupational sensitisation may be the cause of hyperresponsiveness, or develop in those with pre-existing hyperresponsiveness. Around 20% of workers with occupational asthma have measurements within the normal range. Once occupational asthma develops, removal from exposure, particularly if delayed, often results in continuing asthma. Finally the prevention of occupational asthma is discussed.
Effect of Synthesis Temperature on the Growth Iron-Filled Carbon Nanotubes as Evidenced by Structural, Micro-Raman, and Thermogravimetric Analyses (2012)

Tubular structure and well dense of aligned carbon nanotubes (CNTs) were formulated using two-stage catalytic chemical vapor deposition apparatus. In this experiment, aligned CNT was synthesized in the range of 700–900°C temperatures with increment rate of 50°C per sample. The aligned CNT properties were investigated via field emission scanning electron microscope, micro-Raman spectrometer and thermogravimetric analyzer. The experimental results showed that aligned CNT properties were highly dependent on synthesis temperature changes. The optimum temperature of higher crystallinity was observed at 800°C synthesis temperature. However, the highest yield of nanotubes (~99.99%) was obtained at 900°C synthesis temperature. Aligned CNT orientation was in a parallel form and packed together in orderly manner. The behaviors of aligned CNT will be discussed in detail in this paper.
[The synthesis and separation of optically pure hydroxy ethers]. (1987)

By using optically pure R and S 3-quinuclidinols. two pairs of diastereoisomers (R-1) and (R-2), (S-1) and (S-2) were synthesized. Each pair was further separated by preparative TLC. The mobile phase was chloroform-methanol-ammonia water (8:2:0.07). There is a marked distinction among their affinities for M-cholinergic receptor in rat hrain The work is still in progress.
An asynchronous distributed discrete event simulation algorithm for cyclic circuits using a data-flow network (2002)

The authors propose a mathematically proven algorithm for asynchronous, distributed, discrete-event simulation of circuits containing feedback loops. Every component of the circuit is represented through an executable model and the flow of information is expressed through message communication. Simulation time is encapsulated in the model description and encoded in the messages. A data-flow network is synthesized based on the connectivity of the components in the circuit that computes a quantity time of next event for every component. This quantity permits the corresponding model to execute asynchronously as far ahead in simulation time as possible and yet guarantees correctness. The network ensures that any simulation process executing on a distributed processing environment that has sufficient information to simulate can execute while also avoiding deadlock. The algorithm has been verified through an implementation on loosely coupled parallel processor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Database analyses for the prediction of <i>in vivo</i> drug–drug interactions from <i>in vitro</i> data (2004)

The use of the total hepatic input concentration of inhibitor together with in vitro K(i) values was the most successful method for the categorization of putative CYP inhibitors and for identifying negative drug-drug interactions. However this approach should be considered as an initial discriminating screen, as it is empirical and requires subsequent mechanistic studies to provide a comprehensive evaluation of a positive result.
SEGMENTATION IN CHICKS IMAGE USING ARTIFICIAL NEURAL NETWORK (2018)

This work proposal is for localization of suspicious noise in chick's images by selecting regions of interest. The presence of salt and pepper noise, speckle noise in an image becomes a difficult task to delimit a lesion. Some techniques of digital processing were applied in 100 chick's images in order to minimize the noise allowing posterior extraction of the contour. The segmentation techniques used to extract the contour was performed by means of the artificial neural network selforganizing map. The various metric evaluation were used to compare the proximity of the automatically obtained area with the manual outline of a animal husbandry, resulting in percent values of 93% to accuracy, 68% to sensitivity and 98% to positive predictive value.
SymPy: Symbolic computing in Python (2016)

SymPy is an open source computer algebra system written in pure Python. It is built with a focus on extensibility and ease of use, through both interactive and programmatic applications. These characteristics have led SymPy to become the standard symbolic library for the scientific Python ecosystem. This paper presents the architecture of SymPy, a description of its features, and a discussion of select domain specific submodules. The supplementary materials provide additional examples and further outline details of the architecture and features of SymPy.
Development and Application of a PCR-Targeted Gene Disruption Method for Studying CelR Function in <i>Thermobifida fusca</i> (2010)

Thermobifida fusca is a high-G+C-content, thermophilic, Gram-positive soil actinobacterium with high cellulolytic activity. In T. fusca, CelR is thought to act as the primary regulator of cellulase gene expression by binding to a 14-bp inverted repeat [5'-(T)GGGAGCGCTCCC(A)] that is upstream of many known cellulase genes. Previously, the ability to study the roles and regulation of cellulase genes in T. fusca has been limited largely by a lack of established genetic engineering methods for T. fusca. In this study, we developed an efficient procedure for creating precise chromosomal gene disruptions and demonstrated this procedure by generating a celR deletion strain. The celR deletion strain was then characterized using measurements for growth behavior, cellulase activity, and gene expression. The celR deletion strain of T. fusca exhibited a severely crippled growth phenotype with a prolonged lag phase and decreased cell yields for growth on both glucose and cellobiose. While the maximum endoglucanase activity and cellulase activity were not significantly changed, the endoglucanase activity and cellulase activity per cell were highly elevated. Measurements of mRNA transcript levels in both the celR deletion strain and the wild-type strain indicated that the CelR protein potentially acts as a repressor for some genes and as an activator for other genes. Overall, we established and demonstrated a method for manipulating chromosomal DNA in T. fusca that can be used to study the cellulolytic capabilities of this organism. Components of this method may be useful in developing genetic engineering methods for other currently intractable organisms.
General discussion (1979)

Abstract In order to analyse quantitatively the images obtained by using the Radiation Dynamics Super X, 8 MeV linear accelerator, Rolls-Royce have developed a system of close-range X-ray photogrammetry. In order to study the behaviour of components in motion, it is necessary to provide a flow of images from which specific events may be identified in a qualitative manner to allow a radiograph to be made for detailed measurement purposes. The use of real-time video techniques also allows the speed of an event or the rate of flexure of components to be determined, giving an indication of the nature of the force creating the movement. This may, for instance, be a thermal growth which may be slow or a pressure force which is likely to be more rapid in change. By using the Super X in the stroboscopic mode linked to engine speed, it is possible to identify eccentricity of compressor spacer rings. The video then allows the determination of the time when the ring becomes free and eccentric.
Preparation and Characterization of Laminin-Derived Peptide AG73-Coated Liposomes as a Selective Gene Delivery Tool (2010)

Targeted gene delivery to cancer cells is considered as a promising strategy for cancer therapy. Since, several targeting ligands have been studied for cancer gene therapy, such as transferrin, folate, anisamide, RGD-peptide, and antibodies. We have focused on AG73 peptide, which is derived from the globular domain of the laminin α1 chain. AG73 peptide is known as a ligand for syndecans, one of the major heparin sulfate-containing transmembrane proteoglycans. Syndecan-2 is highly expressed in various cancer cells and plays a role in angiogenesis. In this study, we prepared AG73-labeled polyethyleneglycol-modified liposomes (AG73-PEG liposomes) for gene delivery tool to syndecan-2 overexpressing cancer cells, and assessed the characterization of AG73-PEG liposomes. We confirmed the conjugation of AG73 peptide to PEG liposomes by reverse-phase high-performance liquid chromatography analysis. Electron microscopy analysis showed that monodiseperse AG73-labeled lipsomes were prepared. We also assessed the gene transfection efficiency of AG73-PEG liposomes in syndecan-2 overexpressing cancer cells or syndecan-2 less expressing cancer cells. As a result, AG73-mediated liposomal gene transfection efficiency was increased by 100-fold in syndecan-2 overexpressing cancer cells compared to syndecan-2 less expressing cancer cells. These results suggested that AG73-PEG liposomes were successfully prepared from a point of view of the modification of AG73 peptide to PEG-liposomes and the particle size of liposomes, which presented nano size. Furthermore, our results suggest that AG73-PEG liposomes can be a useful targeted gene delivery vehicle for syndecan-2 overexpressing cancer cells.