gebhart/patrepeval huggingface dataset:
A Framework for the Management of Operator Policies and User Preferences for Service Compositions in the IP Multimedia Subsystem (2011)

The IP Multimedia Subsystem (IMS) is a telecommunication middleware platform with robust service features that enables the delivery of a wide range of services to mobile network subscribers. Network operators are encouraged to develop services from service building blocks in order to avoid redundancies by re-using existing functionality. In this environment, operators must be able to control the service execution chain in order to prevent undesirable interactions from occurring between individual building blocks. It is also in their interests to provide subscribers with personalisation options so that they can modify service compositions and define their own preferences for how they would like their services to behave during live sessions. This paper describes a solution for these challenges that involves the storage of service information in an XDMS and allows operator staff and subscribers to manage this information using the XCAP protocol. The ETSI-defined XCAP application usage named simservs was chosen to demonstrate an application usage that can be used to create service compositions in XML format. A prototype is described that uses components of the open source Mobicents project to verify the suitability of the design. This work is part of a larger effort aimed at modeling interaction management in the IMS through the use of a service broker that is part of an extended IMS service layer (EISL). The service broker's functional and structural architecture have not yet been standardised.
A flexible solution to deploy avionics displays to multiple Embedded Platforms (2008)

Avionics HMI developers depend on both in-house and COTS HMI tools in their day-to-day work. Unfortunately, many of these solutions support only a narrow set of embedded computing platforms or do not meet the performance requirements that a program defines. This means that engineering choices can be limited for HMI software and hardware combinations at the initial design phase and that seemingly straightforward hardware upgrades during an aircraftpsilas lifecycle can become problematic.
The Neuronal Growth-Associated Protein GAP-43 Induces Filopodia in Non-Neuronal Cells (1989)

The neuron-specific protein GAP-43 is associated with the membrane of the nerve growth cone and thus may be important to the activity of this distinctive neuronal structure. Transient transfection of COS and NIH 3T3 cells with appropriate vectors resulted in expression of GAP-43 in these non-neuronal cells; as in neurons, transfected GAP-43 associated with the membrane. In addition, many long fine filopodial processes extended from the periphery of such transfected cells. Stable CHO cell lines expressing GAP-43 also exhibited processes that were more numerous, far longer, and more complex than those of CHO cell lines not transfected or transfected with control plasmids. Thus GAP-43 may directly contribute to growth cone activity by regulating cell membrane structure and enhancing extension of filopodial processes.
Characterization of Endogenous Gibberellins in Dwarf Rice Mutants (1996)

The elongation response of 17 near-isogenic dwarf lines of the Shiokari rice cultivar to gibberellins (GAs) was examined. Two strains, ID-18h and ID-19, were selected for further analysis of their endogenous GA levels. It is suggested that ID-18h dwarfism is caused by the deficiency of GA 3Jl-hydroxylation activity, and ID-19 dwarfism by the insensitivity of the elongation response to physiologically active GAs.
Molecular Architecture of Native HIV-1 gp 120 Trimers (2008)

HIV/AIDS: gp120 structure changes This paper investigates the structure of the HIV the gp120 coat protein of HIV by cryo-electron tomography and molecular modelling. Comparison of gp120 structures in an unbound state, bound to a neutralizing antibody and bound to CD4 cell surface protein provides insight into the conformational changes that occur during antibody neutralization and attachment to target cells.
Thermal Rearrangement of Branched-Chain Methylpolysiloxanes<sup>1</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThermal Rearrangement of Branched-Chain Methylpolysiloxanes1Donald W. ScottCite this: J. Am. Chem. Soc. 1946, 68, 3, 356–358Publication Date (Print):March 1, 1946Publication History Published online1 May 2002Published inissue 1 March 1946https://pubs.acs.org/doi/10.1021/ja01207a003https://doi.org/10.1021/ja01207a003research-articleACS PublicationsRequest reuse permissionsArticle Views1271Altmetric-Citations243LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Streptococcus ictaluri sp. nov., isolated from Channel Catfish Ictalurus punctatus broodstock (2007)

A streptococcal-like organism was associated with diseased Channel Catfish Ictalurus punctatus broodstock on four commercial aquaculture operations in the Mississippi Delta. Conventional biochemical testing, 16S rRNA gene sequence analysis and DNA-DNA hybridization distinguished the isolates from these fish from previously published Streptococcus species. Comparative 16S rRNA gene sequencing studies revealed that the isolates were phylogenetically most similar to Streptococcus iniae, Streptococcus uberis and Streptococcus parauberis with divergence ranging from 2.0 to 2.3 %. Streptococcus pyogenes, Streptococcus urinalis, Streptococcus dysgalactiae subsp. dysgalactiae and Streptococcus canis were included in the analysis and showed even greater differences (2.5-3.2 % divergence). DNA relatedness was 22 % or less to the most phylogenetically related species at the optimal temperature. These data suggest that the isolates represent a novel species of Streptococcus for which the name Streptococcus ictaluri sp. nov. is proposed. The type strain is 707-05(T) (=SO2-1108(T)=ATCC BAA-1300(T)=CCUG 52536(T)).
Development of a Pasted Nickel Electrode with High Active Material Utilization (1989)

A high‐performance and low‐cost pasted nickel electrode made from a metal fiber substrate has been developed. The electrode is designed so that it exhibits active material utilization close to 100%, with an energy density as high as 170 mAh/g or 520 mAh/cm3. This high active material utilization, even with a metal fiber substrate, which is a poor current collector compared with a conventional sintered nickel powder plaque, has been made possible by adding which dissolves and precipitates on the surface of nickel hydroxide particles as during standing and then is converted to during the subsequent charging, which provides a good electrical path between the nickel hydroxide particles and the metal fiber substrate. Thus‐formed is not reduced in the subsequent discharges of the electrode and serves as a good current collector to ensure a high active material utilization throughout the life of the electrode.
A cocktail party effect in the median plane? (1999)

Recent research has been conducted on the effects of spatialized audio on a listener’s ability to detect and identify a target speech signal when presented among nontarget speech signals in the horizontal plane [W. T. Nelson et al., Proceedings of the 1998 IMAGE Conference (1998), pp. 159–166]. However, the existence of a ‘‘cocktail party effect’’ in the median plane has not been addressed. The purpose of the present investigation was to determine whether or not the spatial separation of multiple simultaneous speech sources in the median plane leads to improved detection and intelligibility. Independent variables include the number and angular separation of the speech signals, the sex of the target talker, and the presence or absence of head motion cues. All speech signals—phrases from a modified Coordinate Response Measure [T. J. Moore, AGARD Conference Proceedings 311: Aural Communication in Aviation (1981), pp. 2.1–2.6]—were digitally filtered via nonindividualized HRTFs and presented over headphones. Results will be compared with those obtained in the horizontal plane. Inplications for the design of auditory displays will be discussed.
An internal friction study of polytetrafluoroethylene (1959)

Abstract A torsion pendulum has been used to measure the internal friction of polytetrafluoroethylene. The crystallinity of the specimens varied form 48 to 92%, and the measurements were made over a wide temperature range. The site of each relaxation was assigned by observing the variation of relaxation strength and peak height with crystallinity. In this way amorphous relaxations were found to occur at 176.5°K. (0.60 cycle/sec.) and 399°K. (0.62 cycle/sec.). The crystallite relaxations occur at 291°K. (0.28 cycle/sec.) and the crystallite melting point, 600°K. It is concluded that the amorphous regions of polytetrafluoroethylene exist in three phases between 4.2°K. and the crystallite melting point. The supercooled liquid which exists below 600°K. is transformed into an amorphous solid at a temperature in the region of 400°K. This solid undergoes another transformation at approximately 176°K. to form a third phase which is stable down to 4.2°K. The crystallite realaxation centered at 291°K. consists of a series of disordering transitions including the well‐known first‐order transition. There is evidence that hindered rotation occurs within the crystallites at temperatures as low as 220°K.
Some observations on fingerprint deposits (1975)

Measurements of refractive indices and droplet profiles of fingerprint deposits on flat solid surfaces have been made using transmitted light interference microscopy. Changes in the profile with time and relative humidity have been determined. From these measurements inferences are made on the structure of the droplets. The absence of significant variation in contact angle for fingerprints on substrates of different surface energy is explained in terms of a contaminant film over the area of finger ridge contact. The thickness of this film corresponds closely to that expected for a monolayer of contamination.
Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors (2015)

Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the intracellular activation of TAF. Here we further investigated the role of CatA and other human hydrolases in the metabolism of TAF. Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively. Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold. Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs. The covalent hepatitis C virus (HCV) protease inhibitors (PIs) telaprevir and boceprevir potently inhibited CatA-mediated TAF activation (50% inhibitory concentration [IC50] = 0.27 and 0.16 μM, respectively) in vitro and also reduced its anti-HIV activity in primary human CD4(+) T lymphocytes (21- and 3-fold, respectively) at pharmacologically relevant concentrations. In contrast, there was no inhibition of CatA or any significant effect on anti-HIV activity of TAF observed with cobicistat, noncovalent HIV and HCV PIs, or various prescribed inhibitors of host serine proteases. Collectively, these studies confirm that CatA plays a pivotal role in the intracellular metabolism of TAF, whereas the liver esterase Ces1 likely contributes to the hepatic activation of TAF. Moreover, this work demonstrates that a wide range of viral and host PIs, with the exception of telaprevir and boceprevir, do not interfere with the antiretroviral activity of TAF.
A Data Integration Broker for Healthcare Systems (2007)

A prototype information broker uses a software service model to collect and integrate diverse patient data from autonomous healthcare agencies, potentially solving many problems that challenge current enterprise-based file systems
Getting along: composition of visualization paradigms (2005)

This paper describes how focus+context techniques can be composed with other high-level visualization paradigms to mutual advantage. Examples are given showing composition both with a pan\&zoom system, and with a treemap implementation. The examples illustrate how focus+context can be used as an exploration and navigation tool within those paradigms.
THE USE OF NICKEL AS A CATALYST FOR HYDROGENATION (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE USE OF NICKEL AS A CATALYST FOR HYDROGENATIONHomer Adkins and Howard I. CramerCite this: J. Am. Chem. Soc. 1930, 52, 11, 4349–4358Publication Date (Print):November 1, 1930Publication History Published online1 May 2002Published inissue 1 November 1930https://pubs.acs.org/doi/10.1021/ja01374a023https://doi.org/10.1021/ja01374a023research-articleACS PublicationsRequest reuse permissionsArticle Views2646Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A dynamic analysis for revealing object ownership and sharing (2006)

We present a dynamic analysis for inferring object ownership and sharing, defined in terms of the write control graph. We render the results in an interactive hierarchical matrix visualizer.The purpose of the analysis and visualization is to reveal object ownership and sharing relations in the program, to facilitate program understanding and modification tasks.
Idiopathic and secondary forms of retroperitoneal fibrosis: A diagnostic approach (2014)

Retroperitoneal fibrosis (RPF) is an uncommon disease characterized by a fibrous reaction that takes place in the peri-aortic retroperitoneum and often entraps the ureters causing obstructive uropathy. RPF is idiopathic in the majority of cases, but can also be secondary to malignancies, infections, drugs, radiotherapy, and rare histiocytic disorders such as Erdheim-Chester disease. Idiopathic RPF is an immune-mediated disease, which can either be isolated, associated with other autoimmune diseases, or arise in the context of a multifocal fibro-inflammatory disorder recently renamed as IgG4-related disease. The differential diagnosis between idiopathic, IgG4-related and secondary RPF is crucial, essentially because the therapeutic approaches - especially of idiopathic vs. secondary RPF - can be dramatically different. This review focuses on the clinical, laboratory and imaging features of the different RPF forms, and also provides an overview of the available treatment options.
ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF PHOSPHORYLATED PHENYL ACETATES AND HYDRAZIDES (1982)

Abstract Durch Umsetzung der Phosphinigsäureester (I) mit α‐Halogen‐phenylessigsäureestern (II) erhält man die α‐Phosphinylphenylessigsäureester (III).
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones (1993)

The design, synthesis, and biological evaluation of a new class of inhibitors of thymidylate synthase (TS) is described. The molecular design was carried out by a repetitive crystallographic analysis of protein-ligand structures. At the onset of this project, we focused on the folate cofactor binding site of a high-resolution ternary crystal complex of Escherichia coli TS, 5'-fluorodeoxyuridylate (5-FdUMP) and a classical glutamate-containing folic acid analog. A preliminary ternary crystal structure of a novel compound was successfully solved. Upon analysis of this initial complex, further structural elaborations were made, and a series of active 5-(arylthio)quinazolinones was developed. The synthetic strategy was based on the displacement of a halogen at the 5-position of a quinazolinone by various aryl thioanions. The compounds were tested for inhibition of purified E. coli and/or human TS, and were assayed for cytotoxicity against three tumor cell lines in vitro. Significant thymidine protection effects were observed with several of the inhibitors, indicating that TS was the intracellular locus of activity.
Evaluating Service Identification with Design Metrics on Business Process Decomposition (2009)

One of the key activities to construct a successful Service-Oriented Architecture (SOA) is the identification of services with the right level of abstraction. Most of existing SOA design methodologies advocate identifying services from the top-down decomposition of business processes. However, the identification quality in these methodologies heavily depends on the expertise and experience of individual designers. The ability to quantitatively evaluate service identification is absolutely needed. In this paper, we propose an approach that supports such evaluation by applying the measurement technology to the service-based business process decomposition. A model to capture related architectural elements with their relationships is presented. A set of design metrics are proposed for measuring various features of identified services in the service portfolio, including service granularity, coupling, cohesion, and business entity convergence. To apply the approach, a prototypical measurement tool for service identification is developed. An automotive work order scenario is used as an illustration example to explain our approach and demonstrate its effectiveness.
Expression of a Novel Protocadherin, OL-Protocadherin, in a Subset of Functional Systems of the Developing Mouse Brain (1999)

We cloned a novel protocadherin cDNA, which we named OL-protocadherin (OL-pc), from mouse brain cDNA libraries. Its cytoplasmic region showed no similarities to other protocadherins, indicating that it belongs to a novel subfamily of protocadherins. Experiments using transfectants showed that OL-pc is a homophilic cell-cell adhesion molecule. The molecular mass of OL-pc was 140 kDa in the brain. Expression of OL-pc mRNA was specific to the nervous system, changing over time from the embryonic stage to the adult stage. The OL-pc expression seemed to be restricted to a subset of functionally related brain nuclei and regions such as the nuclei in the main olfactory system, the limbic system, and the olivocortical projection. There were at least two distinct patterns of distribution for the OL-pc protein. First, it was localized in particular brain nuclei or compartments, such as the stripes of the developing cerebellum. Second, it was found at the synapse in regions such as the glomeruli of the olfactory bulb. In addition, the OL-pc protein seemed not to be detected or was detected only weakly in some regions, such as hippocampus in which the mRNA was expressed at high levels. These results indicate that the expression of OL-pc is developmentally regulated in a subset of the functional systems and that it may be involved in the formation of the neural network by segregation of the brain nuclei and mediation of the axonal connections.
Lamivudine treatment for acute severe hepatitis B: report of a case and review of the literature. (2008)

The oral nucleoside analogue lamivudine has been effectively used in the treatment of chronic hepatitis B. However, there is limited data concerning the efficacy and safety of lamivudine in patients with severe acute or fulminant hepatitis B. We report the use of lamivudine in a young woman with acute HBV infection and fulminant hepatic failure. Following lamivudine treatment, we noticed a prompt clinical, biochemical, serological and virological response as it was seen in the vast majority of, previously reported, cases. Lamivudine treatment was continued until HBsAg was cleared. Our case, as well as previously reported ones, suggests that lamivudine may have a beneficial effect in selected patients with acute severe or fulminant HBV infection.
Blue Light-Directed Destabilization of the Pea Lhcb1*4 Transcript Depends on Sequences within the 5' Untranslated Region (1999)

Mary Beth Anderson, Kevin Folta, Katherine M. Warpeha, Jack Gibbons, Jie Gao, Lon S. Kaufman, Blue Light-Directed Destabilization of the Pea Lhcb1*4 Transcript Depends on Sequences within the 5′ Untranslated Region, The Plant Cell, Vol. 11, No. 8 (Aug., 1999), pp. 1579-1589
Treatment of human mesenchymal stem cells with pulsed low intensity ultrasound enhances the chondrogenic phenotype in vitro (2006)

This study examined the effects of low intensity pulsed ultrasound (LIPUS) on human bone marrow-derived mesenchymal stem cells undergoing chondrogenic differentiation. Aggregates of mesenchymal stem cells and mesenchymal stem cells seeded in three dimensional matrices were cultured in a defined chondrogenic medium and subjected to LIPUS for the first 7 days of culture. At 1, 7, 14 and 21 days, samples were harvested for histology, immunohistochemistry, RT-PCR, and quantitative DNA and matrix macromolecule analysis. Cell aggregates with daily treatment for 20 minutes showed no significant differences for proteoglycan and collagen content during chondrogenic differentiation. However ultrasound application for 40 minutes daily resulted in a statistically significant increase of the proteoglycan and collagen content after 21 days in culture. Aggregates treated for 20 minutes daily showed decreased expression of chondrogenic genes at all time points. In contrast, 40 minutes of daily treatment of aggregates resulted in a significant increase of chondrogenic marker genes after an initial decrease at day 7 with time in culture. Ultrasound treated cell-scaffold constructs showed a significant increase of chondrogenic marker gene expression and extracellular matrix deposition. This study indicates that LIPUS can be used to enhance the chondrogenesis of mesenchymal stem cells in cell aggregates and cell-scaffold constructs. We have found a dependency on the specific treatment parameters. We hypothesize that LIPUS can be used for an improved in vitro preparation of optimized tissue engineering implants for cartilage repair. Furthermore this non-invasive method could also be of potential use in vivo for regenerative therapy of cartilage in the future.