gebhart/patrepeval huggingface dataset:
Topology discovery by active probing (2003)

As the Internet has grown, so has the challenge of accurate measurement and modeling of its topology. Commonly used but coarse methods of measuring topology, e.g., BGP tables, suffer from several limitations. To pursue more accurate empirically-based topology modeling, in 1998 CAIDA began its Macroscopic Topology Project, which focuses on actively measuring topology and round trip time (RTT) information across a large cross-section of the commodity Internet. We describe CAIDA's topology measurement architecture and our analysis and visualization tools. We describe differences between IP and AS (BGP-based) granularities of topology modeling, including advantages and limitations of both, as well as how correlation between both types of data can yield more relevant insights. We introduce four new visualization metaphors for handling macroscopic topology data, as well as a tool for aggregating multiple IP addresses into the same physical router. We highlight results of our analyses, in particular relationships between RTT and topology data, and how source and destination selection and geopolitical boundaries affect those relationships.
Integrin affinity modulation in angiogenesis (2008)

Integrins, transmembrane glycoprotein receptors, play vital roles in pathological angiogenesis, but their precise regulatory functions are not completely understood and remain controversial. This study aims to assess the regulatory functions of individual beta subunits of endothelial integrins in angiogenic responses induced by vascular endothelial growth factor (VEGF). Inhibition of expression of beta(1), beta(3), or beta(5) integrins in endothelial cells resulted in down regulation of EC adhesion and migration on the primary ligand for the corresponding integrin receptor, while no effects on the recognition of other ligands were detected. Although inhibition of expression of each subunit substantially affected capillary growth stimulated by VEGF, the loss of beta(3) integrin was the most inhibitory.
Cardiovascular effects of the N-methyl-D-aspartate receptor antagonist MK-801 in conscious rats. (1989)

Evidence from microinjection studies in anesthetized rats suggests that central excitatory amino acid pathways using N-methyl-D-aspartate receptors are involved in the regulation of the cardiovascular system. To test the hypothesis that these pathways are tonically involved in the maintenance of or the baroreceptor reflex regulation of cardiovascular function, we have examined the effects of intravenous injection of the centrally acting, noncompetitive N-methyl-D-aspartate receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), on the mean arterial pressure, heart rate, renal sympathetic nerve activity, and behavior of conscious, freely moving sham-operated and sinoaortic baroreceptor-denervated rats. Administration of MK-801 produced, within 5 minutes, dose-dependent elevations in mean arterial pressure, heart rate, and renal sympathetic nerve activity that were sustained for 0.5 to 2.5 hours. For an equivalent dose, MK-801 produced approximately twice the peak changes in mean arterial pressure and heart rate in the sinoaortic baroreceptor-denervated rats than in the sham-operated rats. Pretreatment results were as follows: 1) The ganglion blocker chlorisondamine markedly attenuated the hypertension and tachycardia in the sham-operated and sinoaortic baroreceptor-denervated rats, 2) pretreatment with the alpha 1-adrenergic receptor antagonist prazosin virtually abolished the hypertension, and 3) the beta 1-adrenergic receptor antagonist atenolol markedly reduced the tachycardia. MK-801 also produced stereotypic behaviors and ataxia in the sham-operated and sinoaortic baroreceptor-denervated rats; however, qualitatively and quantitatively similar changes in behavior were induced in the latter by doses approximately five time lower than required in sham operated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Oxidative addition of soluble iridium and rhodium complexes to carbon-hydrogen bonds in methane and higher alkanes (1984)

Abstract
The Histamine H4 Receptor: A Novel Target for Safe Anti-inflammatory Drugs? (2015)

The functional role of histamine H 4 receptors (H 4 Rs) in the Gastrointestinal (GI) tract is reviewed, with particular reference to their involvement in the regulation of gastric mucosal defense and inflammation. H 4 Rs have been detected in different cell types of the gut, including immune cells, paracrine cells, endocrine cells and neurons, from different animal species and humans; moreover, H 4 R expression was reported to be altered in some pathological conditions, such as colitis and cancer. Functional studies have demonstrated protective effects of H 4 R antagonists in several experimental models of gastric mucosal damage and intestinal inflammation, suggesting a potential therapeutic role of drugs targeting this new receptor subtype in GI disorders, such as allergic enteropathy, Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS) and cancer.
Aaron Baker (1920)

Journal Article Aaron Baker Get access H. R. Popham Baker H. R. Popham Baker Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-VI, Issue 105, 17 April 1920, Page 139, https://doi.org/10.1093/nq/s12-VI.105.139 Published: 17 April 1920
Problems of Audience (1991)

All writers take cognisance of audience, though it is true that they may look for audience no further than themselves. Writers who set out to write for children, however, must look further than themselves, for they are separated from children, even from the children they once were, by a substantial barrier of age and experience, a barrier which, though it may in some ways be surmounted or traversed, cannot be removed. Whatever some of them have said to the contrary, writers for children must serve two masters, themselves and their chosen audience.
Isamelt technology - current status and future development (1997)

The Isasmelt process was developed at Mount Isa Mines Limited in Queensland, Australia in collaboration with CSIRO, the Australian Government research organisation. Originally developed for primary lead smelting, culminating in the construction of a 60,000 tonnes per annum lead smelter at Mount Isa, this technology now also provides a major part of the current 200,000 tonnes per annum copper smelting capacity at Mount Isa. A programme is now in place to expand copper production to 250,000 tonnes per annum. The technology has also been applied to secondary lead smelting at Britannia Refined Metals, a MIM subsidiary company, where a 30,000 tonnes per annum lead plant based on battery scrap feed has been operating since 1991. Mount Isa Mines Limited decided to license the technology in 1988, and copper smelting plants utilising Isasmelt technology are now operated by Cyprus Miami Mining Corporation in the USA and by Sterlite Industries in India. In addition, the technology was adopted by AGIP for smelting copper/nickel concentrates in Australia. Union Miniere are currently constructing an Isasmelt furnace to smelt and convert copper-containing materials at their plant at Hoboken in Belgium. This paper discusses these developments and also some likely future developments which include the application of the technology for continuous copper and nickel converting and applications in the treatment of zinc-containing residues.
The response of a microwave multipolar bucket plasma to a high-voltage pulse with finite rise time (1992)

A collisional model that describes the response of a microwave multipolar bucket plasma to a high-voltage pulse with finite risetime has been developed for plasma immersion ion implantation (PIII). The agreement between this model and the measurements of the sheath position and target current in a 100 mtorr helium plasma is found to be much improved when the risetime of the pulse and the ion energy distribution during the PIII process is considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pathogenesis and treatment of HTLV-I associated myelopathy. (1998)

That HTLV-I is not a latent infection is indicated by the detection of mRNA in the peripheral blood and CNS of patients with HTLV-I infection and by the persisting humoral and cellular immune responses. Indeed the frequency of anti-HTLV CTL is extremely high. The reduction in anti-TAX CTL frequency following reduction in proviral load suggests that removal of viral antigen may result in a reduced inflammatory response at least in peripheral blood and although the clinical data should be interpreted with caution, perhaps in the CNS. Patients with more advanced disease, and possibly fixed deficits may not benefit from either anti-inflammatory or antiretroviral treatment. The patients with most to gain are those with least deficit in whom early diagnosis and treatment will depend on raising awareness of HTLV-I beyond the neurological community. Many patients with HAM first present to a urologist or gynaecologist with bladder dysfunction or may have been seen in the genitourinary clinical with impotence or positive treponemal serology, which in the older patient is often the result of childhood infection with Treponema pallidum pertenue. Investigation of these patients should include HTLV-I serology and further investigation of HTLV-I positive patients should include proviral load measurements as well as markers of inflammation. Treatments whether antiviral or anti-inflammatory should be assessed for their effect on both as well as a clinical response.
Extracting regions of interest from biological images with convolutional sparse block coding (2013)

Biological tissue is often composed of cells with similar morphologies replicated throughout large volumes and many biological applications rely on the accurate identification of these cells and their locations from image data. Here we develop a generative model that captures the regularities present in images composed of repeating elements of a few different types. Formally, the model can be described as convolutional sparse block coding. For inference we use a variant of convolutional matching pursuit adapted to block-based representations. We extend the KSVD learning algorithm to subspaces by retaining several principal vectors from the SVD decomposition instead of just one. Good models with little cross-talk between subspaces can be obtained by learning the blocks incrementally. We perform extensive experiments on simulated images and the inference algorithm consistently recovers a large proportion of the cells with a small number of false positives. We fit the convolutional model to noisy GCaMP6 two-photon images of spiking neurons and to Nissl-stained slices of cortical tissue and show that it recovers cell body locations without supervision. The flexibility of the block-based representation is reflected in the variability of the recovered cell shapes.
[Role of miR-106b-5p in the regulation of gene profiles in endothelial cells]. (2019)

The coexpression pattern of miRNAs in plasma of patients with atherosclerosis is more significantly changed than that of individuals without atherosclerotic disease. MiR-106b-5p, which shows the most significant difference between groups, targets multiple signal pathways in vascular endothelial cells, and might play an important role in the regulatory network of atherosclerotic gene expression.
Clinical Characteristics of Type 2 Diabetes Patients according to Family History of Diabetes (2010)

In T2DM patients with a family history of diabetes, the disease tended to develop earlier. Metabolic syndrome and cardiovascular risk factors are more prevalent in familial T2DM than they were in non-familial T2DM. These results support the necessity of earlier screening for diabetes in family members of T2DM patients and more active prevention against cardiovascular disease in T2DM patients with a family history.
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity (2006)

Colitis involves immune cell-mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here that Vanin-1 deficiency protects from colitis. This protection is reversible by administration of cystamine or bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor (PPAR)gamma antagonist. We further demonstrate that Vanin-1, by antagonizing PPARgamma, licenses the production of inflammatory mediators by intestinal epithelial cells. We propose that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue. Thus, the Vanin-1/pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease.
Polarization Micro-Optics: Circular Polarization From a Fresnel Rhomb 3D Printed on an Optical Fiber (2018)

High-resolution fabrication of three-dimensional polymeric structures with direct laser writing (DLW) holds a unique potential for the miniaturization of bulk optical elements. This has been so far mainly demonstrated for the fabrication of reflective, refractive, and phase-mask micro-optics. Here, we show the use of DLW for the fabrication of a miniaturized phase retarder element, a Fresnel Rhomb, which acts as a broadband quarter-wave plate. We show the integration of the Fresnel Rhomb onto a polarization-maintaining optical fiber, converting linearly polarized light from the fiber into circularly polarized light over a very broad spectral range.
A risk of meaning transfer: Are negative associations more likely to transfer than positive associations? (2012)

Celebrity endorsement is a common influence tactic used by marketers. By linking their brands with cultural entities such as celebrity endorsers, marketers attempt to acquire positive meanings and personality traits associated with the entity. Entities, however, often have both positive and negative associations. For example, a celebrity can be both smart and arrogant, or sexy and ditsy. We highlight a risk of meaning transfer: negative associations are more likely to transfer to a brand than positive associations. Three studies show that brands are more likely to acquire the negative than the positive personality traits associated with a celebrity endorser and that negative associations transfer even under conditions that inhibit the transfer of positive associations.
Why template self-update should work in biometric authentication systems? (2012)

The term adaptive biometric systems refers to biometric recognition systems in which an algorithm aimed to follow variations of the clients appearance has been implemented. Among others, the self update algorithm is used when only one biometric is available, and is able to add to the clients gallery novel data collected during system operation, on the basis of a updating threshold: if the novel data, compared with existing template(s), provide a matching score higher than the given threshold, they are added to the gallery. In order to avoid misclassification errors, thus inserting impostors into the clients gallery, this threshold is very conservative. Self-update algorithm has shown to be effective for many biometrics. However, no work tried to explain, so far, why self-update should work, in particular when a very conservative update threshold is used (zeroFAR threshold). This is the goal of the present paper, which provides a conceptual explanation of the self update mechanism coupled with a set of experiments on a publicly available data set explicitly designed for studying adaptive biometric systems.
High Current Integrated Microinductors and Microtransformers using Low Temperature Fabrication Processes (1997)

In many systems which utilise magnetic components, e.g., miniaturised DC‐DC converters, PCMCIA cards, and modem stand‐off transformers, the magnetic device is the largest single component in the package. Surface‐mount magnetic devices may be unacceptably thick where low profiles are required. The authors's approach to this problem is to use micromachining techniques to realise inductors and transformers built into the multilayer structure of a multi‐chip package, allowing compact integration with chips, sensors and other components. Microinductors and micro‐transformers composed of thick cores and multiwinding conductors have high inductance, high saturation current, and low resistance compared with previous integrated inductors. The total size of the microinductive device is 4 mm ×4 mm× 0.145 mm, having 156 turns of multilevel electroplated copper coils (40 μm thick) and electroplated permalloy magnetic core (35 μm thick). These devices have inductances up to 1.5 μH and current‐carrying capability of up to 3A steady DC current, making them applicable to power converters. The processing steps chosen are all low‐temperature, which allow the use of low‐cost substrates such as MCM‐L compatible materials.
Reassessing the therapeutic range for theophylline on laboratory report forms: the importance of 5-15 micrograms/ml. (1994)

The therapeutic status of theophylline has changed dramatically over the last decade. As part of this change, a different view of the most appropriate therapeutic range for serum theophylline concentration (STC) has emerged. The National Institutes of Health Expert Panel Report, "Guidelines for the Diagnosis and Management of Asthma," suggests a conservative approach of aiming for STC of 5-15 micrograms/ml. This truly landmark document along with several studies in the literature, recently prompted us to change our hospital's laboratory report form for the medical record to read that the therapeutic range for STC is 5-15 micrograms/ml. We encourage hospital laboratories or other clinical laboratories who have not already made this change to do so.
Exposition and Interpretation of the Topology of Neural Networks (2019)

Convolutional neural networks (CNN's) are powerful and widely used tools. However, their interpretability is far from ideal. One such shortcoming is the difficulty of deducing a network's ability to generalize to unseen data. We use topological data analysis to show that the information encoded in the weights of a CNN can be organized in terms of a topological data model and demonstrate how such information can be interpreted and utilized. We show that the weights of convolutional layers at depths from 1 through 13 learn simple global structures. We also demonstrate the change of the simple structures over the course of training. In particular, we define and analyze the spaces of spatial filters of convolutional layers and show the recurrence, among all networks, depths, and during training, of a simple circle consisting of rotating edges, as well as a less recurring unanticipated complex circle that combines lines, edges, and non-linear patterns. We also demonstrate that topological structure correlates with a network's ability to generalize to unseen data and that topological information can be used to improve a network's performance. We train over a thousand CNN's on MNIST, CIFAR-10, SVHN, and ImageNet.
Purification and functional characterization of the human β<sub>2</sub>‐adrenergic receptor produced in baculovirus‐infected insect cells (1991)

A human cDNA fragment bearing the complete coding region for the beta 2-adrenergic receptor was introduced into the genome of Autographa california nuclear polyhedrosis virus under the control of the polyhedrin promoter. Binding studies using [125I]iodocyanopindolol showed that Sf9 insect cells infected with the recombinant virus expressed approximately 1 x 10(6) beta 2-adrenergic receptors on their cell surface. Photoaffinity labeling of whole cells and membranes revealed a molecular weight of approximately 46,000 for the expressed receptor. The receptor produced in insect cells is glycosylated but the extent and pattern differ from that of the receptor from human tissue. The heterologously expressed receptor was purified by alprenolol affinity chromatography, and was able to activate isolated Gs-protein.
Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin (1996)

The bacterium Actinobacillus actinomycetemcomitans has been implicated in the pathogenesis of juvenile periodontitis as the etiologic agent on the basis of several lines of circumstantial evidence. A matter of extensive debate is whether A. actinomycetemcomitans is an exogenous contagious pathogen or an opportunistic pathogen that resides in the normal oral microflora. Here we show evidence of a single clone of A. actinomycetemcomitans isolated from multiple patients with juvenile periodontitis in members of families of African origin living in geographically widespread areas. The clone is characterized by a 530-bp deletion in the leukotoxin gene operon, resulting in a significantly increased production of leukotoxin.
Taming the Monster: A Fast and Simple Algorithm for Contextual Bandits (2014)

We present a new algorithm for the contextual bandit learning problem, where the learner repeatedly takes one of $K$ actions in response to the observed context, and observes the reward only for that chosen action. Our method assumes access to an oracle for solving fully supervised cost-sensitive classification problems and achieves the statistically optimal regret guarantee with only $\tilde{O}(\sqrt{KT/\log N})$ oracle calls across all $T$ rounds, where $N$ is the number of policies in the policy class we compete against. By doing so, we obtain the most practical contextual bandit learning algorithm amongst approaches that work for general policy classes. We further conduct a proof-of-concept experiment which demonstrates the excellent computational and prediction performance of (an online variant of) our algorithm relative to several baselines.