gebhart/patrepeval huggingface dataset:
Settlement and adhesion of algal cells to hexa(ethylene glycol)-containing self-assembled monolayers with systematically changed wetting properties (2007)

Protein resistance of self-assembled monolayers (SAMs) of hexa(ethylene glycols) (EG(6)) has previously been shown to be dependent on the alkoxyl end-group termination of the SAM, which determines wettability [S. Herrwerth, W. Eck, S. Reinhardt, and M. Grunze, J. Am. Chem. Soc. 125, 9359 (2003)]. In the present study, the same series of hexa(ethylene glycols) was used to examine the correlation between protein resistance and the settlement and adhesion of eukaryotic algal cells, viz., zoospores of the macroalga Ulva and cells of the diatom Navicula, which adhere to the substratum through the secretion of protein-containing glues. Results showed that the initial settlement of Ulva zoospores was highest on the hydrophilic EG(6)OH but that cells were only weakly adhered. The number of Ulva zoospores and Navicula cells firmly adhered to the SAMs systematically increased with decreasing wettability, as shown for the protein fibrinogen. The data are discussed in terms of hydration forces and surface charges in the SAMs.
Application Possibility of Bentonite and Zeolite in Bioremediation (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Elastically adaptive deformable models (2002)

We present a technique for the automatic adaptation of a deformable model's elastic parameters within a Kalman filter framework for shape estimation applications. The novelty of the technique is that the model's elastic parameters are not constant, but spatio-temporally varying. The variation of the elastic parameters depends on the distance of the model from the data and the rate of change of this distance. Each pass of the algorithm uses physics-based modeling techniques to iteratively adjust both the geometric and the elastic degrees of freedom of the model in response to forces that are computed from the discrepancy between the model and the data. By augmenting the state equations of an extended Kalman filter to incorporate these additional variables, we are able to significantly improve the quality of the shape estimation. Therefore, the model's elastic parameters are always initialized to the same value and they are subsequently modified depending on the data and the noise distribution. We present results demonstrating the effectiveness of our method for both two-dimensional and three-dimensional data.
Growth hormone and cortisol in serum and saliva (2000)

Salivary diagnosis is a developing area in clinical chemistry and dentistry. Cortisol analyses from saliva have been used in pediatric practice and as doping tests. Growth hormone (hGH), also a stress hormone, has not been analyzed from saliva. We studied the serum and saliva of 51 healthy subjects. The samples were taken at 8:00 in the morning after 12 h fasting. Cortisol concentrations were analyzed using RIA. An immunoradiometric assay was applied for analyzing serum and salivary hGH. The validity of this method developed in our laboratory was found to be good. The results showed correlation of salivary cortisol with that of serum (r = 0.47, P < 0.001). Salivary hGH concentrations were 1000-fold lower than the respective values in serum, but a clear correlation was found between salivary and serum hGH levels (r = 0.59, P < 0.001).
Automatic Object Segmentation from Calibrated Images (2011)

This paper addresses the problem of automatically obtaining the object/background segmentation of a rigid 3D object observed in a set of images that have been calibrated for camera pose and intrinsics. Such segmentations can be used to obtain a shape representation of a potentially texture-less object by computing a visual hull. We propose an automatic approach where the object to be segmented is identified by the pose of the cameras instead of user input such as 2D bounding rectangles or brush-strokes. The key behind our method is a pairwise MRF framework that combines (a) foreground/background appearance models, (b) epipolar constraints and (c) weak stereo correspondence into a single segmentation cost function that can be efficiently solved by Graph-cuts. The segmentation thus obtained is further improved using silhouette coherency and then used to update the foreground/background appearance models which are fed into the next Graph-cut computation. These two steps are iterated until segmentation convergences. Our method can automatically provide a 3D surface representation even in texture-less scenes where MVS methods might fail. Furthermore, it confers improved performance in images where the object is not readily separable from the background in colour space, an area that previous segmentation approaches have found challenging.
Discriminative Correlation Filter with Channel and Spatial Reliability (2017)

Short-term tracking is an open and challenging problem for which discriminative correlation filters (DCF) have shown excellent performance.We introduce the channel and spatial reliability concepts to DCF tracking and provide a novel learning algorithm for its efficient and seamless integration in the filter update and the tracking process. The spatial reliability map adjusts the filter support to the part of the object suitable for tracking. This both allows to enlarge the search region and improves tracking of non-rectangular objects. Reliability scores reflect channel-wise quality of the learned filters and are used as feature weighting coefficients in localization. Experimentally, with only two simple standard features, HoGs and Colornames, the novel CSRDCF method - DCF with Channel and Spatial Reliability - achieves state-of-the-art results on VOT 2016, VOT 2015 and OTB100. The CSR-DCF runs in real-time on a CPU.
Neurophenomenology Integrating Subjective Experience and Brain Dynamics in the Neuroscience of Consciousness (2003)

The paper presents a research programme for the neuroscience of con- sciousness called 'neurophenomenology' (Varela 1996) and illustrates it with a recent pilot study (Lutz et al., 2002). At a theoretical level, neurophenomenology pursues a n e mbodied a nd l arge-scale d ynamical a pproach t o t he neurophysiology of consciousness (Varela 1995; Thompson and Varela 2001; Varela and Thompson 2003). At a methodological level, the neurophenomeno- logical strategy is to make rigorous and extensive use of first-person data about subjective experience as a heuristic to describe and quantify the large-scale neurodynamics of consciousness (Lutz 2002). The paper foocuses on neurophenomenology in relation to three challenging methodological issues about incorporating first-person data into cognitive neuroscience: (i) first-person reports can be biased or inaccurate; (ii) the process of generating first-person reports about an experience can modify that experience; and (iii) there is an 'ex- planatory gap' in our understanding of how to relate first-person, phenomeno- logical data to third-person, biobehavioural data.
Globally diverse <i>Toxoplasma gondii</i> isolates comprise six major clades originating from a small number of distinct ancestral lineages (2012)

Marked phenotypic variation characterizes isolates of Toxoplasma gondii, a ubiquitous zoonotic parasite that serves as an important experimental model for studying apicomplexan parasites. Progress in identifying the heritable basis for clinically and epidemiologically significant differences requires a robust system for describing and interpreting evolutionary subdivisions in this prevalent pathogen. To develop such a system, we have examined more than 950 isolates collected from around the world and genotyped them using three independent sets of polymorphic DNA markers, sampling 30 loci distributed across all nuclear chromosomes as well as the plastid genome. Our studies reveal a biphasic pattern consisting of regions in the Northern Hemisphere where a few, highly clonal and abundant lineages predominate; elsewhere, and especially in portions of South America are characterized by a diverse assemblage of less common genotypes that show greater evidence of recombination. Clustering methods were used to organize the marked genetic diversity of 138 unique genotypes into 15 haplogroups that collectively define six major clades. Analysis of gene flow indicates that a small number of ancestral lineages gave rise to the existing diversity through a process of limited admixture. Identification of reference strains for these major groups should facilitate future studies on comparative genomics and identification of genes that control important biological phenotypes including pathogenesis and transmission.
A Binocular Stereoscopic Display System for Echocardiography (1979)

We describe a three-dimensional cardiographic imaging systém based on the principle of binocular stereoscopy. The system produces a three-dimensional image of the heart chamber from two-dimensional representations, i. e., "ultrasono-tomograms."
Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction (1999)

1 To investigate the functional significance of different troponin T (TnT) isoforms in the Ca2+ activation of muscle contraction, transgenic mice have been constructed with a chicken fast skeletal muscle TnT transgene driven by a cardiac α-myosin heavy chain gene promoter. 2 Cardiac muscle-specific expression of the fast skeletal muscle TnT has been obtained with significant myofibril incorporation. Expression of the endogenous cardiac muscle thin filament regulatory proteins, such as troponin I and tropomyosin, was not altered in the transgenic mouse heart, providing an authentic system for the functional characterization of TnT isoforms. 3 Cardiac muscle contractility was analysed for the force vs. Ca2+ relationship in skinned ventricular trabeculae of transgenic mice in comparison with wild-type litter-mates. The results showed unchanged pCa50 values (5.1 ± 0.04 and 5.1 ± 0.1, respectively) but significantly steeper slopes (the Hill coefficient was 2.0 ± 0.2 vs. 1.0 ± 0.2, P < 0.05). 4 The results demonstrate that the structural and functional variation of different TnT isoforms may contribute to the difference in responsiveness and overall cooperativity of the thin filament-based Ca2+ regulation between cardiac and skeletal muscles.
Nobiletin Inhibits <scp>PDGF‐BB</scp>‐Induced Vascular Smooth Muscle Cell Proliferation and Migration and Attenuates Neointimal Hyperplasia in a Rat Carotid Artery Injury Model (2014)

Preclinical Research The abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) plays a pivotal role in the development of neointimal hyperplasia after vascular injury. Nobiletin, a citrus bioflavonoid, exhibits anti-inflammatory and anti-oxidative activities. The present study evalutaed whether nobiletin could inhibit platelet-derived growth factor (PDGF)-BB- stimulated VSMC proliferation and migration and decrease neointimal hyperplasia in a rat carotid artery injury model. Cultured VSMCs from rat thoracic aortas were treated with nobiletin before being stimulated with 20 ng/ml PDGF-BB, and rats were subjected to carotid artery injury. Nobiletin inhibited PDGF-BB-induced VSMC proliferation and migration, attenuated reactive oxygen species (ROS) production and reduced phosphorylation of ERK1/2 and the expression of nuclear NF-κB p65 in PDGF-BB-stimulated VSMCs. Nobiletin decreased the intima area and the ratio of neointima to media in balloon-injured rat carotid arteries. Serum levels of TNF-α and IL-6 in nobiletin-treated rats were decreased. These results indicated that nobiletin could be a potential protective agent for the prevention and treatment of restenosis after angioplasty.
TD-GC-MS Analysis of Volatile Metabolites of Human Lung Cancer and Normal Cells <i>In vitro</i> (2010)

The aim of this study was to confirm the existence of volatile organic compounds (VOC) specifically released or consumed by the lung cancer cell line A549, which could be used in future screens as biomarkers for the early detection of lung cancer. For comparison, primary human bronchial epithelial cells (HBEpC) and human fibroblasts (hFB) were included. VOCs were detected in the headspace of cell cultures or medium controls following adsorption on solid sorbents, thermodesorption, and analysis by gas chromatography mass spectrometry. Using this approach, we identified VOCs that behaved similarly in normal and transformed cells. Thus, concentrations of 2-pentanone and 2,4-dimethyl-1-heptene were found to increase in the headspace of A549, HBEpC, and hFB cell cultures. In addition, the ethers methyl tert-butyl ether and ethyl tert-butyl ether could be detected at elevated levels in the case of A549 cells and one of the untransformed cell lines. However, especially branched hydrocarbons and alcohols were seen increased more frequently in untransformed than A549 cells. A big variety of predominantly aldehydes and the ester n-butyl acetate were found at decreased concentrations in the headspace of all cell lines tested compared with medium controls. Again, more different aldehydes were found to be decreased in hFB and HBEpC cells compared with A549 cells and 2-butenal was metabolized exclusively by both control cell lines. These data suggest that certain groups of VOCs may be preferentially associated with the transformed phenotype.
Libot: Design of a low cost mobile robot for outdoor swarm robotics (2012)

Robot fabrication has always been a costly matter. Even for educational purposes, one will need to spend substantial amount of money for building single robot with limited capabilities. When it comes to development of higher capabilities and intelligence, more investment will be required. In this paper, we present details of a mobile robot that is specially designed and made to be used as a stand-alone or in a swarm of robots. This robot can navigate outdoor autonomously based on a digital compass, GPS module and a transceiver module to communicate with other robots and a base station as research work in swarm robotics is mainly based on two way communication. Using the same onboard transceiver module, certain limited modifications to this robot would be needed for indoor navigation using wireless sensor networks.
Thrombotic Thrombocytopenic Purpura in Humans and Mice (2007)

Thrombotic thrombocytopenic purpura (TTP) is a disorder of blood coagulation that presents classically with the pentad of fever, thrombocytopenia, microangiopathic hemolytic anemia, renal dysfunction and mental status changes. However, the clinical presentation can be quite variable making the diagnosis difficult in many cases. "Hyaline" microthrombi composed primarily of platelets and Von Willebrand Factor (VWF) are found in the small vessels of affected organs and represent the pathological hallmark of the disease. The accompanying tissue ischemia is thought to explain the clinical TTP signs and symptoms. Pathogenesis of TTP has been linked to dysfunction of ADAMTS13, a metalloprotease whose only known substrate is VWF. Interestingly, further investigation into the natural history of TTP has demonstrated that ADAMTS13 deficiency likely is necessary, but not sufficient for the development of this disease, suggesting that additional genetic and/or environmental factors are required for TTP pathogenesis. Recently, a mouse model of TTP was established that recapitulates many of the key clinical features of this disease, including the requirement for further genetic and environmental factors in addition to ADAMTS13 deficiency. Therefore, in addition to being useful for the direct study of disease pathophysiology in vivo, this mouse model may also play a key role in elucidating some of the important environmental and genetic contributors to disease pathogenesis. Here we will review TTP in humans, and then discuss recent information gained from the analysis of ADAMTS13-deficient mice.
Tracing the 'Messy' History of Forensic DNA Analysis in Canada (2011)

This paper explores the history of scientific controversy surrounding forensic DNA analysis in the Canadian legal system. It focuses on DNA analysis and its introduction to legal cases of sexual assault. Drawing on Actor-Network Theory, this paper explores the scientific and legal controversies that proceeded the ‘black boxing’ of DNA analysis in the medicolegal system. This paper begins by outlining some the important contributors to the invention of DNA analysis and the Sexual Assault Evidence Kit (SAEK), a tool involved in collecting forensic DNA evidence. It then traces critiques from feminists, legal professionals, and scientists, who all raised objections to the introduction of forensic DNA analysis. The paper concludes by considering whether forensic DNA evidence has been successfully ‘black boxed’ in the Canadian medicolegal system. Key words: DNA Analysis; Actor-Network Theory; Canadian legal system
A Variational Bayesian Learning Approach for Nonlinear Acoustic Echo Control (2013)

In this work, we present novel Bayesian algorithms for acoustic echo cancellation and residual echo suppression in the presence of a memoryless loudspeaker nonlinearity. The system nonlinearity is modeled using a basis-generic nonlinear expansion. This allows us to express the microphone observation in the DFT domain in terms of the nonlinear-expansion coefficients and the acoustic echo path. We augment the observation model with first-order Markov models for the echo-path vector and the nonlinear-expansion coefficients to arrive at a composite state-space model. The echo path vector and each nonlinear-expansion coefficient are designated as the unknown random variables in our Bayesian model. The posterior estimators for the random variables and the learning rules for the a priori unknown model parameters are then derived via the maximization of the variational lower bound on the log likelihood. We further show that a Bayesian post-filter for residual echo suppression can be derived by optimizing a minimum-mean-square error (MMSE) cost function subject to marginalization with respect to the posteriors estimated in the echo cancellation stage. The effectiveness of the approach is supported by simulation results and an analysis using instrumental performance measures.
Fixing file descriptor leaks (2007)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.
The benzimidazole anthelmintic agents‐a review (1990)

Peer reviewed
A predictive H.263 bit-rate control scheme based on scene information (2000)

For many real-time visual communication applications such as video telephony, the transmission channel used is typically constant bit rate (e.g. PSTN). Under this circumstance, the encoder's output bit-rate must be regulated to meet the transmission bandwidth in order to guarantee a constant frame rate and delay. We propose a new predictive rate control scheme based on the activity of the scene to be coded for H.263 encoder.
Adaptive resource allocation in SDMA-based wireless broadband networks with OFDM signaling (2003)

The increasing popularity of wireless broadband access in local and wide area networks is the main expression of the need for flexible and ubiquitous wireless connectivity. In order to satisfy user resource requirements in the presence of volatility of the wireless medium, sophisticated multiple access and adaptation techniques are required, which alleviate channel impairments and increase system throughput. The use of multiple antennas at the base station allows intra-cell channel reuse by multiple spatially separable users through space division multiple access (SDMA) and hence enhances cell capacity. However, the employment of antennas in the physical layer raises significant issues in the medium access control (MAC) layer. We investigate the impact of antenna arrays on MAC layer channel allocation in the context of orthogonal frequency division multiplexing (OFDM), which is the predominantly proposed signaling scheme for wireless broadband access. We propose an algorithm to allocate channels to users based on their spatial separability properties, while appropriately adjusting beamforming weights and transmission rates for each user in a channel. The unified consideration of such adaptive techniques yields significant throughput benefits.
국내 학술지의 리더십 연구 동향 (1967~2019) (2020)

이 연구는 1967~2019년까지 국내 학술지에 게재된 리더십 연구 동향을 살펴보고 향후 리더십 연구의 발전을 위한기반을 제공하는 데 그 목적이 있었다. 한국교육학술정보원 국내학술지논문 검색서비스에서 제목에 ‘리더십’을 포함한등KCI 재(후보)지 연구물 6,013편을 대상으로 학술지의 연도별 논문 현황과 빈출주제, 연구방법, 학문분야를 분석하였다. 자료...
A Rapid Procedure for the Large Scale Purification of Elastase and Cathepsin G from Human Sputum (1979)

A procedure is described which permits the rapid isolation of large amounts of elastase and cathepsin G from purulent sputum. This procedure involves: (1) digestion of sputum with DNase, (2) extraction of the insoluble residue that remains with 1 M NaCl, pH 8, (3) affinity chromatography on Sepharose-bound Trasylol, and (4) separation of the two enzymes by chromatogrphy on CM-Sephadex. Starting with 500 g of sputum it was possible to isolate 175 mg of each of these two enzymes within 7 to 10 days. Active site titration indicated both enzymes to be at least 97% pure. Disc gel electrophoresis in the presence and absence of SDS and amino acid sequence of the N-terminal region support the conclusion that the elastase and cathepsin G isolated from sputum are identical to the same enzymes isolated directly from the leukocytes of human blood.
Glycosylation of immunoglobulin light chains associated with amyloidosis (2000)

AL amyloidosis is a fatal disease caused by deposition of immunoglobulin light chains in a fibrillarforin (AL) in various organs. By searching the Kabat database of immunoglobulin sequences using the KabatMan software, we have shown that there is a preponderance of the consensus glycosylation sequon (AsnXxxSer/Thr) in the framework regions of amyloid light chains. We have characterised by computer graphics simulations, NMR spectroscopy and carbohydrate biochemistry the structure and conformation of the oligosaccharide from amyloid protein AL MS (lamba1) and from the amyloid associated Bence Jones protein of patient MH (kappa1). These proteins have glycosylation in the hypervariable complementarity-determining region versus framework region, respectively. Both contained a 2-6 sialylated core fucosylated biantennary chain mostly with bisecting GIcNAc. Together our results suggest that light chain glycosylation may be one of several modifications which may render the protein more prone to amyloid formation.
Optical particle sizing for in situ measurements Part 2 (1979)

This paper is Part 2 of a two-part sequence describing an in situ particle sizing counter. Part 2 discusses experimental measurements in both ambient and combustion temperature conditions. Ambient temperature measurements are obtained using a well-characterized mixture of monodispersions of known size and concentration. The amplitude data are unfolded by the technique described in Part 1, and number density vs particle diameter results are compared with the known input mixture of four monodispersions. An analysis of error propagation in the inversion scheme is presented. For combustion conditions, known mixtures of silica beads in the 1–30-μm range are injected into a small burner, and measurements by the particle counter are shown to reproduce satisfactorily the input size distribution of the glass bead polydispersion. The paper concludes with an assessment of potential applications of the counter to high number density, absorbing, and irregular aerosols.