gebhart/patrepeval huggingface dataset:
<i>Thermobifida fusca</i>family-6 cellulases as potential designer cellulosome components (2006)

During the course of our studies on the structure–function relationship of cellulosomes, we were interested in converting the free cellulase system of the aerobic bacterium, Thermobifida fusca, to a cellulosomal system. For this purpose, the cellulose-binding modules (CBM) of two T. fusca family-6 cellulases, endoglucanase Cel6A and exoglucanase Cel6B, were replaced by divergent dockerin modules. Thus far, family-6 cellulases have not been shown to be members of natural cellulosome systems. The resultant chimaeric proteins, 6A-c and t-6B, respectively, were purified and found to interact specifically and stoichiometrically with their corresponding cohesin modules, indicating their suitability for use as components in ‘designer cellulosomes’. Both chimaeric enzymes showed somewhat decreased but measurable levels of activity on carboxymethyl cellulose, consistent with the known endo- and exo-glucanase character of the parent enzymes. The activity of 6A-c on phosphoric acid swollen cellulose was also consistent with that of the wild-type endoglucanase Cel6A. The startling finding of the present research was the extent of degradation of this substrate by the chimaeric enzyme t-6B. Wild-type exoglucanase Cel6B exhibited very low activity on this substrate, while the specific activity of t-6B was 14-fold higher than the parent enzyme.
The Interaction of Two Homeobox Genes, <i>BREVIPEDICELLUS</i> and <i>PENNYWISE</i> , Regulates Internode Patterning in the Arabidopsis Inflorescence (2003)

Plant architecture results from the activity of the shoot apical meristem, which initiates leaves, internodes, and axillary meristems. KNOTTED1-like homeobox (KNOX) genes are expressed in specific patterns in the shoot apical meristem and play important roles in plant architecture. KNOX proteins interact with BEL1-like (BELL) homeodomain proteins and together bind a target sequence with high affinity. We have obtained a mutation in one of the Arabidopsis BELL genes, PENNYWISE (PNY), that appears phenotypically similar to the KNOX mutant brevipedicellus (bp). Both bp and pny have randomly shorter internodes and display a slight increase in the number of axillary branches. The double mutant shows a synergistic phenotype of extremely short internodes interspersed with long internodes and increased branching. PNY is expressed in inflorescence and floral meristems and overlaps with BP in a discrete domain of the inflorescence meristem where we propose the internode is patterned. The physical association of the PNY and BP proteins suggests that they participate in a complex that regulates early patterning events in the inflorescence meristem.
Melting Relations of CaO‐Manganese Oxide and MgO‐Manganese Oxide Mixtures in Air (1963)

Melting relations in the systems CaO‐manganese oxide and MgO‐manganese oxide in air have been determined at temperatures up to 1705°C. In the system CaO‐manganese oxide four crystalline phases have stable existence in equilibrium with liquids: lime (approximate composition CaO‐MnO), spinel (approximate composition Mn 3 O 4 ‐CaMn 2 O 4 ), and two ternary solid solution phases in which Ca/Mn ratios as well as oxygen contents vary over considerable ranges. One of these ternary solid solution phases may for the sake of simplicity be represented approximately by the formula CaMnO 3 and the other by the formula CaMn 2 O 4 . Three isobaric invariant situations exist, with temperatures and phase assemblages as follows: At 1588°± 10°C the two crystalline phases lime and CaMnO 3 coexist in equilibrium with liquid (40 wt% CaO, 60 wt% manganese oxide) in a peritectic situation. Another peritectic at 1455°± 5°C is characterized by the equilibrium coexistence of CaMnO 3 , CaMn 2 O 4 , and liquid (25 wt% CaO, 75 wt% manganese oxide). A eutectic situation exists at 1439°± 5°C with CaMn 2 O 4 , spinel, and liquid (18 wt% CaO, 82 wt% manganese oxide) present together in equilibrium. In the system MgO‐manganese oxide in air periclase‐manganosite solid solution (approximate composition MgO‐MnO) and spinel (approximate composition Mn 3 O 4 ‐MgMn 2 O 4 ) are the only crystalline phases present in equilibrium with liquids. Liquidus and solidus temperatures increase with increasing MgO content. A peritectic situation exists at 1587°± 10°C, with the two crystalline phases coexisting in equilibrium with liquid (1 wt% MgO, 99 wt% manganese oxide).
Unobtrusive In-Home Monitoring of Cognitive and Physical Health: Reactions and Perceptions of Older Adults (2008)

While the potential benefits of unobtrusive in-home sensing technologies for maintaining health and independence of older adults have been highlighted in recent research, little is known about their views toward such technology. The aims of this project were to identify monitoring needs and expectations of community-residing elderly and their family members. Focus groups were presented with examples of in-home monitoring devices and data output; participants were asked to consider whether the data showed information that was meaningful to them, and how and to whom they would like to have such data disseminated. Content analysis of transcripts revealed four dominant themes: maintaining independence, detecting cognitive decline, sharing of information, and the tradeoff between privacy and usefulness of monitoring. The acceptance by elderly of unobtrusive in-home monitoring was closely tied to perceived utility of data generated by such systems. Privacy concerns appeared to be less of an issue than anticipated in this sample.
Solid State Optical Properties of 4-Alkoxy-pyridine Butadiene Derivatives: Reversible Thermal Switching of Luminescence (2008)

The synthesis and optical properties of a series of alkoxyphenyl-pyridyl butadiene derivatives in solution and in the solid state are described. All the derivatives were practically nonfluorescent in solution but showed good fluorescence in the solid-state. The role of molecular packing in controlling the solid-state fluorescence was investigated by studying the X-ray crystal structure of these molecules. One of the derivatives, 4-((1E,3E)-4-(4-butoxyphenyl)buta-1,3-dienyl)pyridine exhibited polymorphism, with the different polymorphs exhibiting visually distinguishable fluorescence. In the natural state it existed as a polymorph exhibiting blue fluorescence, while it’s cooled melt emitted yellow light. The difference could be attributed to a transformation in the molecular packing of the material from a herringbone to a brickstone arrangement, resulting in a change from monomer to J-type aggregate fluorescence. The polymorph exhibiting yellow fluorescence was fairly stable (>6 months) but could be converted back to the original form by keeping the film at 110 °C for a short period of time (∼8–10 min) before slowly cooling to room temperature. The thermally induced changes in fluorescence behavior were clearly reproducible over several cycles, indicating the utility of this material for thermal imaging applications.
Improving Autologous Blood Harvest: Recovery of Red Cells from Sponges and Suction (1987)

The efficacy of red cell salvage was assessed under circumstances which simulated blood loss managed with sponges or suction. Expired banked blood was equally divided and processed by either suction, or absorbing the blood on a sponge followed by rinsing the sponge in saline. These two techniques were used to harvest washed, centrifuged erythrocytes. The volume, haematocrit and free haemoglobin concentration of the banked blood and the processed units were measured, and smears from all units were examined microscopically. The red cell mass was calculated as the product of the volume and haematocrit. The red cell mass recovered by suction and from sponges averaged 93% and 87% respectively. Blood lost in sponges can be recovered and used to increase the available autologous blood, thereby reducing the need for donor blood.
On the real-time computation of DFT and DCT through systolic architectures (1994)

Proposes novel systolic architectures for the real-time computation of the DFT and the DCT. The proposed architectures are suitable for implementation in the VLSI form. Extension of the proposed architectures for the real-time computation of the 2D version of these transforms is also given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
THE INFLUENCE OF DIET ON THE BODY FAT OF THE WHITE RAT (1929)

Some of the questions regarding the synthesis and deposition of fatty acid radicals in the animal body have recently been answered by Ellis and Isbell (1) in their thorough and painstaking study of the soft pork problem.These investigators have clearly demonstrated that the physical and chemical properties of lard are dependent upon the diet, and that the fatty acid make-up of lards is invariably like that of fatty substances in the diet.Thus arachidic acid was present in largest amounts in the "fat" obtained from hogs ingesting peanut oil, a product characterized by its high content of arachidic acid, while the amounts of the linoleyl radical predominated in the oily fats synthesized as a result of the ingestion of soy beans, which contain unusual amounts of that radical.Confirmation of this work came from the hands of Anderson and Mendel (2), who proved that the quality of the "fat" produced by the white rat varies with the diet.Animals on rations containing lipids with high iodine numbers invariably deposited lipids in their tissues with iodine numbers higher than those of the lipids isolated from rats on diets devoid of preformed "fat."Anderson and Mendel (2) also showed that the "soft fat" of an animal like the rat can easily be transformed into the so called "hard fat" by mere dietary changes.The economic significance of this important contribution certainly calls for no discussion.These investigators likewise found that, so far as the iodine number and index of refraction are concerned,
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells (2011)

Over the past decade, histone deacetylase inhibitors have increasingly been used to treat various malignancies. Tubacin (tubulin acetylation inducer) is a small molecule that inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin. We observed a higher antiproliferative effect of tubacin in acute lymphoblastic leukemia (ALL) cells than in normal hematopoietic cells. Treatment with tubacin led to the induction of apoptotic pathways in both pre-B and T cell ALL cells at a 50% inhibitory concentration (IC(50)) of low micromolar concentrations. Acetylation of α-tubulin increases within the first 30 min following treatment of ALL cells with tubacin. We also observed an accumulation of polyubiquitinated proteins and poly(ADP-ribose) polymerase (PARP) cleavage. Furthermore, the signaling pathways activated by tubacin appear to be distinct from those observed in multiple myeloma. In this article, we demonstrate that tubacin enhances the effects of chemotherapy to treat primary ALL cells in vitro and in vivo. These results suggest that targeting HDAC6 alone or in combination with chemotherapy could provide a novel approach to treat ALL.
Lökomoid reaksiyon ile seyreden bir akut miyokard infarktüsü olgusu (2010)

Lökomoid reaksiyon lökosit sayımının kemik iliği dışındaki reaktif sebeplere bağlı olarak 50,000 hücre/ Î¼L üzerine çıkması olarak tanımlanan hematolojik bir hastalıktır. Diagnostik çalışmalar kronik myelojenik lösemi ve kronik nötrofilik löseminin dışlanmasını ve altta yatan sebebin araştırılmasını gerektirir. Lökomoid reaksiyonun major sebeplerini şiddetli infeksiyonlar, intoksikasyonlar, malignensiler, şiddetli kanamalar veya akut hemoliz oluşturmaktadır. Bizim olgumuzda 79 yaşında bayan hasta hastanemize lökomoid reaksiyon ve akut miyokardiyal infarktüs tanıları ile yatırıldı. Lökomoid reaksiyonun altında yatabilecek sebepler araştırıldığında, akut myokard infarktüsüne sekonder olduğu düşünüldü. Anahtar Kelimeler: Lökomoid Reaksiyon; Miyokard İnfarktüsüAbstract:A Case Of Acute Myocardial Infarctus Which Progressing With Leukemoid ReactionLeukemoid reaction is a hematological disorder, defined by a leukocyte count greater than 50,000 cells/Î¼L, caused by reactive causes outside the bone marrow. The diagnostic work-up consists of the exclusion of chronic myelogenous leukemia and chronic neutrophilic leukemia and the detection of an underlying cause. The major causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hemorrhage, or acute hemolysis. In our case, a 79 years old woman was admitted our hospital with leukemoid reaction and acute myocardial infarctus. After detecting the underlying cause of leukemoid reaction, we thought the leukemoid reaction is secondary of akut myocardial infarktus. Key Words: Leukemoid reaction; Myocardial Infarctus.
Nanostructure of Gel-Derived Aluminosilicate Materials (2007)

In the present work, aluminosilicate aerogels prepared under various conditions were compared with respect to their nanostructures and porosity. The purpose of this investigation was to find a suitable way to predict the final product structure and to tailor a required texture. Several Al and Si precursors (Al nitrate, Al isopropoxide, Al acetate, tetraethoxysilane (TEOS), and sodium silicate) were used in our examinations; the solvent content (water and alcohols), surfactants, as well as the catalysts were varied. In addition, the aerogels were subjected to various heat treatments. Hybrid aerogels were synthesized by the addition of different polymers (poly(acrylic acid), polyvinyl acetate, and polydimethylsiloxane). Aluminosilicate and hybrid aerogel structures were investigated by 27Al MAS NMR, SAXS, SEM, and porosity measurements. Loose fractal structures with a good porosity and high Al incorporation can be achieved from TEOS and Al nitrate or isopropoxide via a sol-gel preparation route. The use of Al acetate led to compact aerogel structures independently of the Si precursor, the pH, and the catalyst.
Randomized, Double-Blind Study Comparing Patient Comfort and Safety Between Iodixanol 320 mg I/mL and Iopamidol 370 mg I/mL in Patients Undergoing Peripheral Arteriography - The COMFORT II Trial. (2017)

Iodixanol injections induced significantly less moderate/severe and severe patient discomfort, heat, or pain than iopamidol, with pain contributing the most. Discomfort did not affect image quality.
A Critical Examination of Recruitment Strategy in India and Nigeria (2013)

The 21 st century has brought about a changing environment in the structure, practice and recruitment process in many countries including India and Nigeria.These innovations have tremendous impact in public service delivery.Yet some countries are still caged with their moribund practice of traditional system of administration with an ineffective and inefficient recruitment in their civil services.This paper there fore, examines recruitment strategy in India and Nigeria using secondary source of data collection.The study revealed that, the Indian civil service is more efficient and effective in recruiting more qualified staff.This is so because their recruitment is based on qualification and merit system.On the other hand, the recruitment policy in Nigeria is highly controversial and complex in nature as emphasis is laid on quota system also known as Federal character Principles where merit is being compromised.We recommends that, both the Indian and Nigerian civil service commissions should be given more autonomous existence as this would enable them discharge their functions and responsibilities effectively without fear or favor.
Modified Caspase-3 Assay Indicates Correlation of Caspase-3 Activity with Immunity of Nonhuman Primates to <i>Yersinia pestis</i> Infection (2008)

Defined candidate human vaccines for treating infection by Yersinia pestis, the agent of plague, have been developed. To facilitate evaluation of the vaccines' efficacy, the in vitro caspase-3 assay for cytotoxicity-neutralizing activity was modified and reevaluated. Immune serum-mediated caspase-3 neutralizing activity correlated with protection against infection in a nonhuman primate vaccine model of plague immunity.
A formal method to improve SystemVerilog functional coverage (2012)

Improving functional coverage efficiently in a verification environment based on constrained random simulation could be a difficult task, since some design states are hard to be reached by random input patterns. On the other hand, manually crafting direct test patterns may be time consuming. In this paper, a functional test pattern generation (FTPG) framework is proposed to automatically produce deterministic test patterns for complete coverage. The framework is based on the functional coverage model (covergroup) provided by SystemVerilog, and it could be easily integrated to modern digital design flow. We synthesize a practical subset of covergroup language constructs to enable FTPG by a SAT-solver. An algorithm called MRRS is proposed to minimize the potential large complexity of the synthesized circuits. Preliminary experimental results demonstrate that MRRS could facilitate FTPG to achieve 43X speed-up in average while the maximum speed-up can reach 67X. To the best of our knowledge, this is the first paper which proposes an FTPG method that utilizes covergroups.
Visual classification with multi-task joint sparse representation (2010)

We address the problem of computing joint sparse representation of visual signal across multiple kernel-based representations. Such a problem arises naturally in supervised visual recognition applications where one aims to reconstruct a test sample with multiple features from as few training subjects as possible. We cast the linear version of this problem into a multi-task joint covariate selection model, which can be very efficiently optimized via ker-nelizable accelerated proximal gradient method. Furthermore, two kernel-view extensions of this method are provided to handle the situations where descriptors and similarity functions are in the form of kernel matrices. We then investigate into two applications of our algorithm to feature combination: 1) fusing gray-level and LBP features for face recognition, and 2) combining multiple kernels for object categorization. Experimental results on challenging real-world datasets show that the feature combination capability of our proposed algorithm is competitive to the state-of-the-art multiple kernel learning methods.
Building a better heat pipe (1990)

As fuel prices rise, electric utilities and process plants are increasing their use of air heaters. To overcome disadvantages in standard designs, the authors company has developed a thermo-syphon heat pipe air heater that is operating today in numerous applications. The heat pipe is described in this paper.
A High-Efficient Transformer Using Bond Wires for Si RF IC (2010)

This paper presents a design of a monolithic transformer using bond wires. The proposed transformer structure has several advantages such as high power handling and high efficiency. It shows that the measured insertion loss at the 1.9GHz range is -1.54dB (70%), which is higher than the spiral transformer of the same size. Also, it shows a phase error of less than 1 degree.
Distributed cooperative Bayesian learning strategies (1997)

Abstract This paper addresses the issue of designing an effective distributed learning system in which a number of agent learners estimate the parameter specifying the target probability density in parallel and the population learner (for short, the p-learner) combines their outputs to obtain a significantly better estimate. Such a system is important in speeding up learning. We propose as distributed learning systems two types of the distributed cooperative Bayesian learning strategies (DCB), in which each agent learner or the p-learner employs a probabilistic version of the Gibbs algorithm. We analyze DCBs by giving upper bounds on their average logarithmic losses for predicting probabilities of unseen data as functions of the sample size and the population size. We thereby demonstrate the effectiveness of DCBs by showing that for some probability models, they work approximately (or sometimes exactly) as well as the nondistributed optimal Bayesian strategy, achieving a significant speed-up of learning over it. We also consider the case where the hypothesis class of probability densities is hierarchically parameterized, and there is a feedback of information from the p-learner to agent learners. In this case we propose another type of DCB based on the Markov chain Monte Carlo method, which we abbreviate as HDCB, and characterize its average prediction loss in terms of the number of feedback iterations as well as the population size and the sample size. We thereby demonstrate that for the class of hierarchical Gaussian distributions HDCB works approximately as well as the nondistributed optimal Bayesian strategy, achieving a significant speed-up of learning over it.
Inhibition of Staphylococcal Wound Infection and Potentiation of Antibiotic Prophylaxis by a Recombinant Fragment of the Fibronectin‐Binding Protein of<i>Staphylococcus aureus</i> (2002)

Adherence of Staphylococcus aureus to host tissues is a critical step for colonization and initiation of infection. The fibronectin-binding proteins (FnBPs) of S. aureus have been implicated in adherence and internalization in nonprofessional phagocytes. A recombinant fragment of the fibronectin-binding domains (rFnBF) that potently inhibits S. aureus entry into host cells was generated. To test the hypothesis that rFnBF may attenuate the establishment of infection, the ability of intermuscularly administered rFnBF to prevent abscess formation was determined in a guinea pig model of wound infection. rFnBF exhibited dose-dependent inhibition of abscess formation and, at a 100-microg dose, raised the median infective dose approximately 170-fold, compared with the control. In addition, rFnBF potentiated the benefit of prophylaxis with cefazolin. Thus, exogenous administration of the fibronectin-binding domain of FnBP reduces the risk of staphylococcal abscess formation and should be investigated further as a novel agent for prevention of wound infection.
Solid-state carrier-envelope phase stabilization via quantum interference control of injected photocurrents (2005)

We demonstrate carrier-envelope phase stabilization of a mode-locked Ti:sapphire laser by use of quantum interference control of injected photocurrents in a semiconductor. No harmonic generation is required for this stabilization technique. Instead, interference between coexisting single- and two-photon absorption pathways in the semiconductor provides a phase comparison between different spectral components. The phase comparison, and the detection of the photocurrent that it produces, both occur within a single low-temperature-grown gallium arsenide sample. The carrier-envelope offset beat note fidelity is 30 dB in a 10-kHz resolution bandwidth. The out-of-loop phase-noise level is essentially identical to the best previous measurements with the standard self-referencing technique.