gebhart/patrepeval huggingface dataset:
Adhesive properties of Enterobacter sakazakii to human epithelial and brain microvascular endothelial cells (2006)

Adherence experiments show heterogeneity within different E. sakazakii strains. In agreement with studies on E. cloacae, we found no relationship between the adhesive capacities in E. sakazakii and the eventual production of specific fimbriae. Further studies will have to be carried out in order to determine the adhesin(s) involved in the interaction of E. sakazakii with cells and to enhance knowledge of the pathogenesis of E. sakazakii infection.
Exploring Base‐Pair‐Specific Optical Properties of the DNA Stain Thiazole Orange (2006)

Double-stranded DNA offers multiple binding sites to DNA stains. Measurements of noncovalently bound dye-nucleic acid complexes are, necessarily, measurements of an ensemble of chromophores. Thus, it is difficult to assign fluorescence properties to base-pair-specific binding modes of cyanine dyes or, vice versa, to obtain information about the local environment of cyanines in nucleic acids by using optical spectroscopy. The feasibility to stain DNA and simultaneously probe local perturbations by optical spectroscopy would be a valuable asset to nucleic acid research. So-called FIT probes (forced intercalation probes) were used to pinpoint the location of the DNA stain thiazole orange (TO) in PNADNA duplexes. A detailed analysis of the base-pair dependence of optical properties is provided and enforced binding of TO is compared with "classical" binding of free TO-PRO1. UV-visible absorbance, circular dichroism (CD) and fluorescence spectroscopy, and melting-curve analyses confirmed site-specific TO intercalation. Thiazole orange exhibited base-specific responses that are not observed in noncovalent dye-nucleic acid complexes, such as an extraordinary dependence of the TO extinction coefficient (+/-60 % variation of the averaged epsilon(max) of 57,000 M(-1) cm(-1)) on nearest-neighbor base pairs. TO signals hybridization, as shown by increases in the steady-state fluorescence emission. Studies of TO fluorescence lifetimes in FIT-PNA and in DNADNA and PNADNA complexes highlighted four different fluorescence-decay processes that may be closed or opened in response to matched or single-mismatched hybridization. A very fast decay process (0.04-0.07 ns) and a slow decay process (2.33-3.95 ns) provide reliable monitors of hybridization, and the opening of a fast decay channel (0.22-0.48 ns) that resulted in an attenuation of the fluorescence emission is observed upon the formation of mismatched base pairs.
99mTc-HYNIC-[Tyr3]-octreotide for imaging somatostatin-receptor-positive tumors: preclinical evaluation and comparison with 111In-octreotide. (2000)

TOC can be radiolabeled to high specific activities using HYNIC as a bifunctional chelator. The high specific tumor uptake, rapid blood clearance, and predominantly renal excretion make 99mTc-EDDA-HYNIC-TOC a promising candidate for an alternative to 111In-DTPA-octreotide for tumor imaging.
Low-power and high-stability SRAM technology using a laser-recrystallized p-channel SOI MOSFET (1992)

Laser recrystallization of p-channel SOI MOSFETs on an undulated insulating layer is demonstrated for SRAMs with low power and high stability. Self-aligned p-channel SOI MOSFETs for loads are stacked over bottom n-channel bulk MOSFETs for both drivers and transfer gates. A sufficient laser power assures the same leakage currents between SOI MOSFETs fabricated on an undulated insulating layer in memory cell regions and on an even insulating layer in field regions. The on/off ratio of the SOI MOSFETs is increased by a factor of 10/sup 4/, and the source-drain leakage current is decreased by a factor of 10-10/sup 2/ compared with those of polysilicon thin-film transistors (TFTs) fabricated by using low-temperature regrowth of amorphous silicon. A test 256-kb SRAM fabricated this technology shows improved stand-by power dissipation and cell stability. The process steps can be decreased to 83% of those TFT load SRAMs if both the peripheral circuit and memory cells are made with p-channel SOI and n-channel bulk MOSFETs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparison Between Allograft Plus Demineralized Bone Matrix Versus Autograft in Anterior Cervical Fusion|A Prospective Multicenter Study (1995)

The study revealed that the allograft-demineralized bone matrix construct gives a higher rate of graft collapse and pseudarthrosis when compared with autograft in a prospective series, although the differences were not statistically significant. The pseudarthrosis rate in the series may be high because of the large percentage of smokers and radiographic evaluation techniques. For the purpose of solid radiographic fusion, the use of autograft is recommended in anterior cervical surgery until other acceptable osteoinductive materials are developed.
Experimental evaluation of read performance for RFID-based mobile sensor data gathering applications (2008)

We consider RFID-based sensing applications enabled by passive or semi-passive tags and mobile devices equipped with readers. We experimentally investigate the feasibility of such RFID-based mobile sensor data gathering applications, focusing on UHF RFID devices and indoor scenarios. We examine the impact of various factors, including reader mobility, multiple closely located tags and other key related metrics. Our measurement results suggest the feasibility of using RFID for such applications.
A practical underwater 3D-Laserscanner (2008)

A number of attempts have been made to use the benefits of 3D-Laserscanning techniques in the underwater environment. Unfortunately, due to a number of operative problems with such devices, their accuracy and therefore applicability remains quite low. This paper specifically focuses on these practical issues by expanding on previous works in this area and improving their usability. The result is a calibration procedure for triangulation-based 3D-laserscanners for the underwater environment which provides a very promising precision and reliability, but at the same time does not demand exaggerated deployment overhead.
Protective role for cytosolic phospholipase A<sub>2</sub>α in autoimmune diabetes of mice (2005)

Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) plays an important role in arachidonate pathway. To investigate the contribution of cPLA(2)alpha to autoimmune diabetes, we established non-obese diabetic (NOD) mouse, an excellent model for human type 1 diabetes, deficient in cPLA(2)alpha. These mice showed severe insulitis and a higher incidence of diabetes. In their macrophages, decreased prostaglandin E(2) (PGE(2)) induced by cPLA(2)alpha deficiency, and the increase in production of tumor necrosis factor (TNF)-alpha were observed. These results suggested that cPLA(2)alpha plays a protective role in progression of insulitis and development of autoimmune diabetes by suppression of TNF-alpha production from macrophages.
Bond Energies and Structures of Ammonia–Sulfuric Acid Positive Cluster Ions (2011)

New particle formation in the atmosphere is initiated by nucleation of gas-phase species. The small molecular clusters that act as seeds for new particles are stabilized by the incorporation of an ion. Ion-induced nucleation of molecular cluster ions containing sulfuric acid generates new particles in the background troposphere. The addition of a proton-accepting species to sulfuric acid cluster ions can further stabilize them and may promote nucleation under a wider range of conditions. To understand and accurately predict atmospheric nucleation, the stabilities of each molecular cluster within a chemical family must be known. We present the first comprehensive measurements of the ammonia-sulfuric acid positive ion cluster system NH(4)(+)(NH(3))(n)(H(2)SO(4))(s). Enthalpies and entropies of individual growth steps within this system were measured using either an ion flow reactor-mass spectrometer system under equilibrium conditions or by thermal decomposition of clusters in an ion trap mass spectrometer. Low level ab initio structural calculations provided inputs to a master equation model to determine bond energies from thermal decomposition measurements. Optimized ab initio structures for clusters up through n = 3, s = 3 are reported. Upon addition of ammonia and sulfuric acid pairs, internal proton transfer generates multiple NH(4)(+) and HSO(4)(-) ions within the clusters. These multiple-ion structures are up to 50 kcal mol(-1) more stable than corresponding isomers that retain neutral NH(3) and H(2)SO(4) species. The lowest energy n = s clusters are composed entirely of ions. The addition of acid-base pairs to the core NH(4)(+) ion generates nanocrystals that begin to resemble the ammonium bisulfate bulk crystal starting with the smallest n = s cluster, NH(4)(+)(NH(3))(1)(H(2)SO(4))(1). In the absence of water, this cluster ion system nucleates spontaneously for conditions that encompass most of the free troposphere.
Flexible connectivity and QoE/QoS management for 5G Networks: The 5G NORMA view (2016)

The goal envisioned by 5G NORMA is to develop a novel, adaptive and future-proof 5G mobile network architecture. In order to fulfill these requirements, 5G NORMA envisions an extremely flexible architecture to be deployed in a multi-tier distributed data-center. In this paper we focus on the novel mobility management schemes, QoE/QoS, Control and Orchestration mechanisms that are being developed in 5G NORMA. These modules, that follow the software-defined principle, jointly optimize core and access functions. The final result is a modular architecture that adapts to the requirements of very heterogeneous services, while allowing multiple tenants to share network resources among them, providing hence the flexible connectivity needed by future 5G Networks.
Synthesis and Characterization of Silver(I) Pyrazolylmethylpyridine Complexes and Their Implementation as Metallic Silver Thin Film Precursors (2014)

A series of light- and air-stable silver(I) pyrazolylmethylpyridine complexes [Ag(L(R))]n(BF4)n (L = pyrazolylmethylpyridine; R = H, 1; R = Me, 2; R = i-Pr, 3) and [Ag(L(R))(NO3)]2 (L = pyrazolylmethylpyridine; R = H, 4; R = Me, 5; R = i-Pr, 6) has been synthesized and structurally and spectroscopically characterized. In all of the molecular structures, the pyrazolylmethylpyridine ligands bridge two metal centers, thus giving rise to dinuclear (2, 4, 5, and 6) or polynuclear structures (1 and 3). The role played by the counteranions is also of relevance, because dimeric structures are invariably obtained with NO3(-) (4, 5, and 6), whereas the less-coordinating BF4(-) counteranion affords polymeric structures (1 and 3). Also, through atoms-in-molecules (AIM) analysis of the electron density, an argentophilic Ag···Ag interaction is found in complexes 2 and 4. Thermogravimetric analysis (TGA) shows that the thermolytic properties of the present complexes can be significantly modified by altering the ligand structure and counteranion. These complexes were further investigated as thin silver film precursors by spin-coating solutions, followed by annealing at 310 °C on 52100 steel substrates. The resulting polycrystalline cubic-phase Ag films of ∼55 nm thickness exhibit low levels of extraneous element contamination by X-ray photoelectron spectroscopy (XPS). Atomic force microscopy (AFM) and scanning electron microscopy (SEM) indicate that film growth proceeds primarily via an island growth (Volmer-Weber) mechanism. Complex 4 was also evaluated as a lubricant additive in ball-on-disk tribological tests. The results of the friction evaluation and wear measurements indicate a significant reduction in wear (∼ 88%) at optimized Ag complex concentrations with little change in friction. The enhanced wear performance is attributed to facile shearing of Ag metal in the contact region, resulting from thermolysis of the silver complexes, and is confirmed by energy-dispersive X-ray analysis of the resulting wear scars.
Research Of Ring Mems Rate Integrating Gyroscopes (2013)

This paper To get the angle value with a MEMS rate gyroscope in some specific field, the usual method is to make an integral operation to the rate output, which will lead the error cumulating effect. So the rate gyro is not suitable. MEMS rate integrating gyroscope (MRIG) will solve this problem. A DSP system has been developed to implement the control arithmetic. The system can measure the angle of rotation directly by the control loops that make the sensor work in whole-angle mode. Modeling the system with MATLAB, desirable results of angle outputs are got, which prove the feasibility of the control arithmetic.
Prolidase Dependent Inhibition of Collagen Biosynthesis in Chinese Hamster Ovary Cells (2008)

Collagen is responsible for maintenance of connective tissue integrity, and through interaction with integrin receptors may participate in regulation of numerous physiological and pathological processes. An important role in collagen biosynthesis plays prolidase. It was previously found that nickel chloride inhibited prolidase activity in Chinese hamster ovary cells (CHO-C9). The cells lack any detectable ornithine aminotransferase and P5C synthase activities, and therefore require addition of free proline or glicyl-proline (converted to glycine and proline) for growth. We have found that Ni(II) contributed to decrease in collagen and hydroxyproline content in CHO cells incubated with Gly-Pro, whereas it had no effect on hydroxyproline content in the cells incubated with proline. Decrease in collagen content was not related to decrease in type I collagen mRNA level suggesting regulation of this process at post-transcriptional level. However decrease in expression of Sos and phosphorylated MAP-kinases were found in the cells growing in the presence of Gly-Pro and Ni(II). Decrease in the expression of these proteins was not related to inhibition of signalling induced by growth factors, since no changes were observed in expression of AKT in CHO cells incubated with Ni(II). The results presented provide evidence for important role of prolidase in collagen biosynthesis.
Silver Nanoparticles as Potential Antibacterial Agents (2015)

Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Currently nanotechnology and nanomaterials are fully integrated in common applications and objects that we use every day. In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to summarize the emerging efforts to address current challenges and solutions in the treatment of infectious diseases, particularly the use of nanosilver antimicrobials.
Protective Effect of Dietary Xylitol on Influenza A Virus Infection (2014)

Xylitol has been used as a substitute for sugar to prevent cavity-causing bacteria, and most studies have focused on its benefits in dental care. Meanwhile, the constituents of red ginseng (RG) are known to be effective in ameliorating the symptoms of influenza virus infection when they are administered orally for 14 days. In this study, we investigated the effect of dietary xylitol on influenza A virus infection (H1N1). We designed regimens containing various fractions of RG (RGs: whole extract, water soluble fraction, saponin and polysaccharide) and xylitol, and combination of xylitol with the RG fractions. Mice received the various combinations orally for 5 days prior to lethal influenza A virus infection. Almost all the mice died post challenge when xylitol or RGs were administered separately. Survival was markedly enhanced when xylitol was administered along with RGs, pointing to a synergistic effect. The effect of xylitol plus RG fractions increased with increasing dose of xylitol. Moreover, dietary xylitol along with the RG water soluble fraction significantly reduced lung virus titers after infection. Therefore, we suggest that dietary xylitol is effective in ameliorating influenza-induced symptoms when it is administered with RG fractions, and this protective effect of xylitol should be considered in relation to other diseases.
Dual-polycide gate technology using regrowth amorphous-Si to suppress lateral dopant diffusion (1997)

Process techniques for dual-polycide gate CMOS have been developed. The origin of lateral dopant diffusion is analyzed, and an enlarged-grain dual-polycide gate technology using regrowth amorphous-Si (a-Si) is proposed. Reduction of the dopant absorption into the silicide layer has been observed in the regrowth of a-Si polycide gate structure. Lateral dopant diffusion has been suppressed to less than 0.1 /spl mu/m, and, as a result, 0.2 /spl mu/m n-MOS/p-MOS spacing has been realized under an 850/spl deg/C furnace annealing process. This technology can also achieve current drivability improvement by suppressing the gate depletion simultaneously. Suppression of boron penetration through the gate oxide to the channel region from the p/sup +/ gate has been realized by gate doping ion implantation into the a-Si, and no threshold voltage lowering with small standard deviation has been confirmed. It has been recognized that the above techniques are a possible solution for the dual-polycide gate CMOS structure.
Regularized Least-Mean-Square Algorithms (2010)

We consider adaptive system identification problems with convex constraints and propose a family of regularized Least-Mean-Square (LMS) algorithms. We show that with a properly selected regularization parameter the regularized LMS provably dominates its conventional counterpart in terms of mean square deviations. We establish simple and closed-form expressions for choosing this regularization parameter. For identifying an unknown sparse system we propose sparse and group-sparse LMS algorithms, which are special examples of the regularized LMS family. Simulation results demonstrate the advantages of the proposed filters in both convergence rate and steady-state error under sparsity assumptions on the true coefficient vector.
Brief communication. Possible genetic basis of pederin polymorphism in rove beetles (Paederus riparius) (2000)

In Paederus riparius, (+) females able to biosynthesize the unique hemolymph toxin pederin and (-) females lacking this ability co-occur in natural populations. Larvae descended from both types of females were reared in the laboratory and the imagoes were crossed in order to get information about a possible genetic basis of this polymorphism. The daughters of (+) mothers become (+) females or (-) females, while the progeny of (-) mothers comprises only (-) females. This suggests a matrilineal trait because pederin biosynthesis cannot be inherited from the father. The rather stable proportion of nearly 90% (+) females in collected females is not maintained, however, when the beetles are reared in the laboratory. This observation is discussed with regard to artificial rearing conditions, where individuals are kept separate and cannot prey on conspecifics.
Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion (2008)

Up-regulation of claudin-1 expression and its transformation in invasive and metastatic gastric carcinoma suggest that claudin-1 participates in the transformation of biological behaviors in neoplasms. Further study is needed to elucidate the precise mechanism and the relation of claudin-1 expression with the neoplasm progress.
Conjugal Transfer of Bacteriophage Resistance Determinants on pTR2030 into <i>Streptococcus cremoris</i> Strains (1986)

Agar surface conjugal matings were used to introduce heat-sensitive phage resistance (Hsp) determinants carried on the conjugal plasmid pTR2030 into Streptococcus cremoris KH, HP, 924, and TDM1. Lactose-fermenting (Lac) transconjugants were selected from matings of Lac variants of S. cremoris KH, HP, 924, and TDM1 with Streptococcus lactis ME2 or a high-frequency donor, S. lactis T-EK1 (pTR1040, Lac; pTR2030, Hsp). For all of the S. cremoris strains examined, select Lac transconjugants were completely resistant to plaquing by their homologous lytic phages. In all cases the plaquing efficiencies were less than 10. Acquisition of a 30-megadalton plasmid (pTR2030) in the S. cremoris phage-resistant transconjugants was demonstrated by direct plasmid analysis, by hybridization with P-labeled probes, or by conjugal transfer of pTR2030 out of the phage-resistant transconjugants into a plasmid-cured recipient, S. lactis LM2302. Acid production, coagulation ability, and proteolytic activity of phage-resistant transconjugants in milk were comparable to those of their phage-sensitive parents. Further, S. cremoris phage-resistant transconjugants were not attacked by phage in starter culture activity tests, which included a 40 degrees C incubation period. The results demonstrated that phage resistance determinants on pTR2030 could be conjugally transferred to a variety of S. cremoris strains and confer resistance to phage under conditions encountered during cheese manufacture. Phage-resistant transconjugants of S. cremoris M43 and HP were also constructed without the use of antiblotic markers to select conjugal recipients from mating mixtures.
Corporate investment and ownership in real estate in Singapore: Some empirical evidence (1999)

The proportion of real estate in a non‐property company’s asset portfolio has increased to an extent where it has become an asset capable of enhancing corporate wealth. This initial study hopes to establish the foundation and provide background information on corporate real estate holding profiles of listed Singapore business firms. Using financial statement data and firm market values from 1987 to 1996, this paper provides an analysis of real estate holdings in both absolute and relative terms. Real estate holdings by business segment and asset subtype, growth in corporate real estate holdings over time; and key financial characteristics of corporate real estate (eg real estate as a percentage of shareholders’ equity and real estate relative to market value of the firm) are included in the paper.
Secure Software Engineering Education: Knowledge Area, Curriculum and Resources (2016)

This paper reviews current efforts and resources in secure software engineering education, with the goal of providing guidance for educators to make use of these resources in developing secure software engineering curriculum. These resources include Common Body of Knowledge, reference curriculum, sample curriculum materials, hands-on exercises, and resources developed by industry and open source community. The relationship among the Common Body of Knowledge proposed by the Department of Homeland Security, the Software Engineering Institute at Carnegie Mellon University, and ACM/IEEE are discussed. The recent practices on secure software engineering education, including secure software engineering related programs, courses, and course modules are reviewed. The course modules are categorized into four categories to facilitate the adoption of these course modules. Available hands-on exercises developed for teaching software security are described and mapped to the taxonomy of coding errors. The rich resources including various secure software development processes, methods and tools developed by industry and open source community are surveyed. A road map is provided to organize these resources and guide educators in adopting these resources and integrating them into their courses.