gebhart/patrepeval huggingface dataset:
1,25-Dihydroxyvitamin D3 Is an Autonomous Regulator of the Transcriptional Changes Leading to a Tolerogenic Dendritic Cell Phenotype, (2009)

Activation of vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D(3) (1,25-vitD) reprograms dendritic cells (DC) to become tolerogenic. Previous studies suggested that 1,25-vitD could inhibit the changes brought about by differentiation and maturation of DCs. Underpinning the described phenotypic and functional alterations, there must be 1,25-vitD-coordinated transcriptional events. However, this transcriptional program has not been systematically investigated, particularly not in a developmental context. Hence, it has not been explored how 1,25-vitD-regulated genes, particularly the ones bringing about the tolerogenic phenotype, are connected to differentiation. We conducted global gene expression analysis followed by comprehensive quantitative PCR validation to clarify the interrelationship between 1,25-vitD and differentiation-driven gene expression patterns in developing human monocyte-derived and blood myeloid DCs. In this study we show that 1,25-vitD regulates a large set of genes that are not affected by differentiation. Interestingly, several genes, impacted both by the ligand and by differentiation, appear to be regulated by 1,25-vitD independently of the developmental context. We have also characterized the kinetics of generation of 1,25-vitD by using three early and robustly regulated genes, the chemokine CCL22, the inhibitory receptors CD300LF and CYP24A1. We found that monocyte-derived DCs are able to turn on 1,25-vitD sensitive genes in early phases of differentiation if the precursor is present. Our data collectively suggest that exogenous or endogenously generated 1,25-vitD regulates a large set of its targets autonomously and not via inhibition of differentiation and maturation, leading to the previously characterized tolerogenic state.
D3-P2P: Managing Distributed and Replicated Database in P2P Environment by Using Quorum System (2012)

The need for large-scale data sharing between autonomous and possibly heterogeneous decentralized systems on the Web led to the concept of P2P database systems. In this paper, we present D3- P2P a new architecture which allows to manage a distributed and replicated database, in Peer-To-Peer (P2P) system with high node dynamicity. This architecture is based on a quorum system to solve problems of concurrent update and nodes failure. The proposed architecture allows assigning a unique timestamp to each distributed transaction in order to build a local precedence order graph in each peer, to select the server replicas and to coordinate the distributed execution of the transaction. To avoid deadlock between nodes, we propose a fully distributed algorithm.
Direct Synthesis of Ketones from Primary Alcohols and 1-Alkenes (1998)

Two consecutive catalytic reactions, the oxidation of a primary alcohol by hydrogen transfer and the subsequent intermolecular hydroacylation in the presence of 2-amino-4-methylpyridine (AMP), take place in a generally applicable one-pot synthesis of ketones from primary alcohols and 1-alkenes catalyzed by transition metals [Eq. (a)]; R = aryl, R′ = alkyl.
Multi-agent Interaction Based Collaborative P2P System for Fighting Spam (2006)

The spam problem is getting worse though so many anti-spam filters have been applied. In this paper, we propose a novel method to utilize the interaction between multi agents in a peer-to-peer system for spam filtering. There are mainly two kinds of agents in our system: local agent for filtering spam and learning spam's feature; social agent for searching the same or approximate mails. When a mail arrives, the local agent takes charge at first; the mail is classified into three categories: non-spam, spam, suspicious spam. Only the suspicious spam is sent to the P2P network by social agent for a collaborative judgment. The result of judgment is returned to local agent, then local agent learning this judgment, so when next time the same or approximate spam arrives, the local agent can block it. The whole procedure can be accomplished without user's supervision, or if the user makes decision beyond the system his interest profile can be learnt by system therefore the user's precious time is saved. Analysis of the experiment result show that the system can filter spam efficiently and cost less bandwidth.
JPEG XT: A New Family of JPEG Backward-Compatible Standards (2016)

The Joint Photographic Experts Group recently produced a new standard, JPEG eXTension. JPEG XT is both backward-compatible with legacy JPEG and offers the ability to encode images of higher precision and higher dynamic range, and in lossy or lossless modes. Here, the authors shed some light on the recent developments of the JPEG committee and discuss both the current status of JPEG XT and its future plans.
From wafer level to panel level mold embedding (2013)

The constant drive to further miniaturization and heterogeneous system integration leads to a need for new packaging technologies which also allow large area processing and 3D integration with potential for low cost applications. Large area mold embedding technologies and embedding of active components into printed circuit boards (Chip-in-Polymer) are two major packaging trends in this area. Mold embedding is currently done on wafer level, typically with diameters of 8“ to 12”, for future process optimization, PCB technologies offer the potential of real large areas up to 610 × 457 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . For mold embedding as e.g. for fan-out wafer level packaging compression molding equipment is used in combination with liquid, granular or sheet epoxy molding compounds, with the boundary condition, that mold processes do need a product specific tool (with defined diameter & thickness). Within this paper the potential of tool-less lamination processes, a standard in PCB manufacturing, is evaluated. Lamination is done in panel format using well-known molding compounds from wafer level compression molding. To evaluate the potential of today's encapsulants for large area embedding processes, different liquid, granular and sheet molding compounds have been intensively evaluated on their processability, on process & material induced die shift and on resulting warpage - all on panel level. Acting as an interconnection layer, PCB based redistribution technologies using lamination of resin coated copper (RCC) films are used. Within the paper, different RCC materials are introduced and discussed concerning their reliability potential based on the available layer thicknesses and thermo-mechanical material properties. The feasibility of the proposed technologies is demonstrated using a two chip package. Dies are embedded in panel size by lamination technologies. Subsequently the wiring is done by lamination of an RCC film over the embedded components and on the panel backside for double sided redistribution. In a process flow also similar to conventional PCB manufacturing μvias to the die pads and through mold vias are drilled using a UV laser and are metalized by Cu-electroplating in one step. This way dies are connected to the front copper layer as well as front to backside of the panel. Conductor lines and pads are formed by Cu etching. Finally, a solder mask and a solderable surface finish are applied. If solder depots are necessary, e.g. for BGA packages, those can be applied by solder balling equipment - either by printing or by preform attach. In summary this paper describes the potential to move from wafer level to panel level mold embedding technology in combination with PCB based redistribution processes. The technology described offers a cost effective packaging solution for e.g. single chip packages as well as for future sensor/ASIC systems or processor/memory stacks in volume production.
Comparative study on effects of blood enriching on mouse model of blood deficiency syndrome induced by cyclophosphamide of albiflorin, paeoniflorin on levels of GM-CSF, IL-3 and TNF-α (2015)

Albiflorin had the effect of blood enriching by regulating the immune function, same with the paeoniflorin. The probable mechanism of nourishing blood and liver of Paeoniae Radix Alba was not only the better effect of adjusting the content of TNF-α, but also might act synergistically with paeoniflorin.
Developments and future potentials of anaerobic membrane bioreactors (AnMBRs) (2012)

The coupling of anaerobic biological process and membrane separation could provide excellent suspended solids removal and better biomass retention for wastewater treatment. This coupling improves the biological treatment process while allowing for the recovery of energy through biogas. This review gives a basic description of the anaerobic wastewater treatment process, summarizes the state of the art of anaerobic membrane bioreactors (AnMBRs), and describes the current research trends and needs for the development of AnMBRs. The research interest on AnMBR has grown over the conventional anaerobic processes such as upflow anaerobic sludge blanket (UASB). Studies on AnMBRs have developed different reactor configurations to enhance performances. The AnMBR performances have achieved comparable status to other high rate anaerobic reactors. AnMBR is highly suitable for application with thermophilic anaerobic process to enhance performances. Studies indicate that the applications of AnMBR are not only limited to the high strength industrial wastewater treatment, but also for the municipal wastewater treatment. In recent years, there is a significant progress in the membrane fouling studies, which is a major concern in AnMBR application.
Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus (1993)

We observed that Sendai virus preinduction of peripheral blood mononuclear cells and subsequent mitogenic stimulation resulted in: (i) Superproduction of interferon-gamma, (IFN-gamma) (ii) an increase in interleukin-2 (IL-2) synthesis that correlates with DNA synthesis when stimulated with phytohemagglutinin (PHA) or pokeweed mitogen (PWM) after treatment with the Sendai virus, while stimulation with Protein A from Staphylococcus aureus was not affected, and (iii) enhanced tumor necrosis factor-alpha (TNF-alpha) production in response to bacterial lipopolysaccharide (LPS). Treatment of monocyte cultures with LPS and cycloheximide or actinomycin-D inhibited the superinduction phenomenon. When cycloheximide was added at the viral induction time, the inhibition of TNF-alpha superproduction and DNA synthesis was still observed. These results suggest that Sendai virus lymphocyte superinduction is specific for a particular stimulatory pathway, not dependent on mRNA accumulation, and probably mediated by induction of an activating protein.
Climate for Innovation, Creative Efficacy and Team Innovation: The Moderating Role of Team Leadership (2013)

摘要： 在团队层次探讨创新氛围、创新效能感以及团队领导对团队创新绩效的影响。对51个工作团队的研究结果表明, 团队创新氛围与团队创新绩效有显著的正向关系, 而团队创新效能感在这一关系中起到中介作用。同时, 引领创新的团队领导调节了创新效能感与团队创新绩效之间的关系, 团队领导越倾向于引领创新, 创新效能感与创新绩效之间的关系就越强, 经由创新效能感传导的创新氛围对创新绩效的效应也就越大。研究结果深刻揭示了创新氛围、创新效能感、创新领导和团队创新之间的关系。
C−H Bond Activation by a Rare Cationic Iridium Dinitrogen Complex. An Important Electronic Effect in the Chemistry of the Hydridotris(pyrazolyl)borate Ligand (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTC−H Bond Activation by a Rare Cationic Iridium Dinitrogen Complex. An Important Electronic Effect in the Chemistry of the Hydridotris(pyrazolyl)borate LigandDavid M. Tellers and Robert G. BergmanView Author Information Department of Chemistry, University of California and Division of Chemical Sciences Lawrence Berkeley National Laboratory Berkeley, California 94720 Cite this: J. Am. Chem. Soc. 2000, 122, 5, 954–955Publication Date (Web):January 21, 2000Publication History Received15 September 1999Published online21 January 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/ja993347ehttps://doi.org/10.1021/ja993347erapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1095Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Hydrocarbons,Ligands,Metals,Nitrogen,Transition metals Get e-Alerts
Yerba Mate (Ilex paraguariensis) modulates NF-kappaB pathway and AKT expression in the liver of rats fed on a high-fat diet (2014)

To investigate the effect of Yerba Mate (YM) aqueous extract intake on the NF-kB pathway and AKT expression in the liver, muscle, and adipose tissue of rats submitted to a high-fat diet (HFD). Male Wistar rats were fed a control (CON) (n = 24) or a HFD (n = 24) for 12 weeks. Afterwards, rats received YM daily (1 g/kg body weight) for 4 weeks. Intake of YM aqueous extract reduced body weight gain (p < 0.05) and total blood cholesterol (p < 0.05) in the HFD group in comparison to the non-treated HFD group. HFD group demonstrated an increased glycemic response at 5 and 10 min after insulin injection. YM decreased the ratio between phosphorylated and total kinase inhibitor of κB (IKK), increased the ratio of phosphorylated to total form of protein kinase B (AKT) and reduced NF-κB phosphorylation in the liver of the HFD group. Our data suggest a beneficial role of YM in improving metabolic dysfunctions induced by HFD.
Complete Local Tumor Regression with Antibody to Fibrin Fragment E (1975)

Rabbit antibody to fibrin fragment E (FFE) was used in an immunotherapy model for the treatment of the line-10 ascites variant of a diethylnitrosamine-induced hepatoma in strain 2 guinea pigs. When 0.75 or 1.0 mg of an IgG preparation containing anti-FFE antibody was injected s.c. 6 and 16 days after the injection of a uniformly lethal dose of line-10 tumor cells, complete regression of the i.d. growing tumor was observed in all 18 strain 2 guinea pigs treated. Thus, this therapy appears to be more effective than any BCG or other immunotherapeutic regimen thus far reported for this tumor. No significant anti-tumor effect was noted when normal rabbit IgG or smaller doses (0.25 or 0.50 mg) of the anti-FFE IgG preparation were used. The injection sites exhibited an inflammatory response for 7 to 10 days characterized by erythema and hemorrhage. Since all animals were treated after the metastatic progression of the tumor is known to frequently occur, the long-term tumor-free survival of these animals as well as their resistance to subsequent tumor challenge indicate that the anti-FFE antibody therapy led to systemic tumor immunity.
Vitamin D-Binding Protein Influences Total Circulating Levels of 1,25-Dihydroxyvitamin D3 but Does Not Directly Modulate the Bioactive Levels of the Hormone in Vivo (2008)

Mice deficient in the expression of vitamin D-binding protein (DBP) are normocalcemic despite undetectable levels of circulating 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]. We used this in vivo mouse model together with cells in culture to explore the impact of DBP on the biological activity of 1,25(OH)(2)D(3). Modest changes in the basal expression of genes involved in 1,25(OH)(2)D(3) metabolism and calcium homeostasis were observed in vivo; however, these changes seemed unlikely to explain the normal calcium balance seen in DBP-null mice. Further investigation revealed that despite the reduced blood levels of 1,25(OH)(2)D(3) in these mice, tissue concentrations were equivalent to those measured in wild-type counterparts. Thus, the presence of DBP has limited impact on the extracellular pool of 1,25(OH)(2)D(3) that is biologically active and that accumulates within target tissues. In cell culture, in contrast, the biological activity of 1,25(OH)(2)D(3) is significantly impacted by DBP. Here, although DBP deficiency had no effect on the activation profile itself, the absence of DBP strongly reduced the concentration of exogenous 1,25(OH)(2)D(3) necessary for transactivation. Surprisingly, analogous studies in wild-type and DBP-null mice, wherein we explored the activity of exogenous 1,25(OH)(2)D(3), produced strikingly different results as compared with those in vitro. Here, the carrier protein had virtually no impact on the distribution, uptake, activation profile, or biological potency of the hormone. Collectively, these experiments suggest that whereas DBP is important to total circulating 1,25(OH)(2)D(3) and sequesters extracellular levels of this hormone both in vivo and in vitro, the binding protein does not influence the hormone's biologically active pool.
Symmetric inertial confinement fusion capsule implosions in a high-yield-scale double-Z-pinch-driven hohlraum on Z (2003)

Detailed radiation-hydrodynamics calculations indicate that the dual-63-MA Z-pinch high-yield (HY) 220-eV inertial confinement fusion concept [Phys. Plasmas 6, 2129 (1999)] may release 400 MJ of fusion yield, if pulse shaping, capsule preheat, and x-radiation drive uniformity can be acceptably controlled. Radiation symmetry is under detailed investigation in an advanced, 70-eV HY-scale scoping hohlraum [Phys. Rev. Lett. 88, 215004 (2002)] driven by the single 20-MA power feed of Sandia National Laboratories’ Z accelerator. The time-averaged polar radiation asymmetry, 〈ΔI〉/I, is inferred from direct distortion measurements of an imploding capsule’s limb-darkened (“backlit”) shell, via 6.7 keV point projection x-ray imaging. Thus far, 〈ΔI〉/I has been measured at the 3.0±1.4 (%) level, on the best shots, in hohlraums (cylindrical) with length/radius ratios L/R of 1.61 and 1.69, either side of a L/R=1.66 predicted optimum for a zeroed P2 Legendre mode. Simulations suggest that when scaled to 220 eV with zeroed odd Legendre modes, relevant to the best fraction of shots on a dual power-feed HY accelerator, the increased hohlraum wall albedo would reduce the field asymmetry to the 0.9% level; thus approaching the uniformity requirements of high-yield ignition. Future studies at L/R=1.66 will include refinements in experimental methods and image analysis techniques (denoising), and the measured symmetry is anticipated to improve further.
Design aspects for CPI robust BEOL (2014)

In this paper we present our methodology to establish a quantitative comparison of the induced stresses at different locations of the package and their effect on the strength of the back-end-of-line (BEOL). A Chip Stack Package (CSP) with tight pitch and lead free solder joints is used as test vehicle. Different configurations of the interconnection between the solder balls and the BEOL, including a stiff passivation layer combined with a polyimide stress buffer layer with different thickness and openings are analyzed. It was found that the bending moment of the outermost solder joint induces high tensile stresses in the BEOL layer and this stress is reduced by increasing the thickness of the passivation layer. For this particular case, an optimal geometry of the stress buffer, in terms of thickness and open diameter is proposed. The stresses and energy release rate (ERR) induced on the BEOL is analyzed in a 2 metal layer configuration with different densities of via interconnections. The strength of the BEOL is improved when increasing both, the stiffness of the low-k material and the density of vias.
Two related proteolipids and dolichol-linked oligosaccharides accumulate in motor neuron degeneration mice (mnd/mnd), a model for neuronal ceroid lipofuscinosis (1994)

In this study, we show that two biochemical markers of neuronal ceroid lipofuscinoses (NCLs) are present in a mutant mouse (mnd/mnd) that exhibits symptoms of the disease. Subunit c of the mitochondrial F1F0-ATP synthase, a proteolipid that accumulates in storage bodies of most forms of NCL and several animal models, is dramatically increased in mnd/mnd mouse brain, kidney, liver, heart, and pancreas. Interestingly, another related proteolipid, subunit c of the vacuolar H(+)-ATPase, also accumulates in several mnd/mnd tissues. The molar ratio of the vacuolar subunit c to the F1F0 subunit c is approximately one to two in enriched storage bodies from brain. The relative accumulation of the vacuolar subunit c correlates with its abundance in normal tissues. It appears in decreasing amounts in brain, kidney, and liver and is not detected in heart or pancreas. Aged mice and two mutant mouse lines, juvenile bare (jb) and mucopolysaccharidosis, type VII (gusmps), did not accumulate either of these proteolipids. Dolichol-linked oligosaccharides also accumulate in NCLs and are increased 17-fold in mnd/mnd mouse brain. Thus, mnd/mnd mice seem to be an excellent model for NCLs since they not only share clinical signs and histopathology, but also two biochemical markers. The accumulation of the vacuolar subunit c in this model may prove to be a marker for distinguishing different forms of NCLs.
Predicting new superhard phases (2010)

The search for new superhard materials is of great importance in view of their major roles played for the fundamental science and the industrial applications. Recent experimental synthesis has made several great successes, but the difficulties associated with synthesis in general remain. Materials design technique is greatly desirable as a request to assist experiment. In this paper, two rational theoretical methods of design of superhard materials have been reviewed: (i) substitutional method, which is successful in some cases, but limited to the known chemically related phases, and (ii) global free energy minimization method, which can be applied to large scale of materials with the only information of chemical compositions. The successful applications have been described and the main principles are summarized.
Evolutionary computing based secure key management protocol (2010)

The Many cryptographic protocols require random or pseudorandom inputs at various points, e.g., for auxiliary quantities used in generating digital signatures, or for generating challenges in authentication protocols. Security of an algorithm rests in keys. If cryptographically weak process is used to generate keys then the whole system will be weak. Only the key should be secret. Cryptographic mechanisms depend on the confidentiality of keys as algorithms are in the public domain. To engage in secure communications there is a need to securely distribute a secret key or public key. Keys should be dynamic Hence a cryptographically strong key must be generated, and thus the key management becomes the major issue in cryptography. In this paper the ant colony based NP problem solving technique is used along with some random functions to ensure that a strong and efficient key management is achieved for symmetric key cryptography that can be employed in the symmetric key algorithms.