gebhart/patrepeval huggingface dataset:
A Markov-based channel model algorithm for wireless networks (2001)

Techniques for modeling and simulating channel conditions play an essential role in understanding network protocol and application behavior. In [11], we demonstrated that inaccurate modeling using a traditional analytical model yielded significant errors in error control protocol parameters choices. In this paper, we demonstrate that time-varying effects on wireless channels result in wireless traces which exhibit non-stationary behavior over small window sizes. We then present an algorithm that divides traces into stationary components in order to provide analytical channel models that, relative to traditional approaches, more accurately represent characteristics such as burstiness, statistical distribution of errors, and packet loss processes. Our algorithm also generates artificial traces with the same statistical characteristics as actual collected network traces. For validation, we develop a channel model for the circuit-switched data service in GSM and show that it: (1) more closely approximates GSM channel characteristics than a traditional Gilbert model and (2) generates artificial traces that closely match collected traces' statistics. Using these traces in a simulator environment enables future protocol and application testing under different controlled and repeatable conditions.
Serum C-reactive protein in children with adenovirus infection (2002)

Paediatric adenovirus infection is associated with substantially elevated CRP concentrations in the absence of secondary bacterial infection. CRP levels were independent of the duration of illness, indicating that adenoviruses trigger an immediate inflammatory host response resembling invasive bacterial infection.
Reduction of 1-substituted 7-chloro-7-fluoronorcaranes with tributyltin hydride (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of 1-substituted 7-chloro-7-fluoronorcaranes with tributyltin hydrideTeiichi Ando, Takashi Ishihara, Eiichi Ohtani, and Hiroki SawadaCite this: J. Org. Chem. 1981, 46, 22, 4446–4450Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/jo00335a024https://doi.org/10.1021/jo00335a024research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tissue Inhibitor of Metalloproteinase (TIMP)-1 Induces Differentiation and an Antiapoptotic Phenotype in Germinal Center B Cells (1998)

Tissue inhibitors of metalloproteinases (TIMPs) have been shown to be multifunctional factors. Contrasting with their enzyme-inhibitory activity, TIMPs also promote cell growth. Previously, we have reported an enhanced expression of TIMP-1 by normal reactive B cells and high-grade lymphomas. In the present study, a series of Burkitt’s lymphoma (BL) cell lines were analyzed for their expression of TIMP-1. TIMP-1 expression correlates with upregulation of activation and survival markers. TIMP-1–negative cells express the phenotype associated with group I BL lines and Epstein-Barr virus (EBV)-negative, nonendemic BLs (CD10+, CD38+, sIg+, and CD77+). However, TIMP-1+ BL lines showed group II/III BL phenotype, downregulation of the above markers, and upregulation and secretion of the activation marker CD23. Also, TIMP-1+ cells have high levels of CD40 expression. To determine whether TIMP-1 is directly involved in the BL phenotype, an EBV-negative BL line JD38 was infected with timp-1–expressing retrovirus and analyzed. In the absence of EBV, upregulation of TIMP-1 is sufficient to induce the same phenotype seen in TIMP-1+, EBV+ BL lines (CD10−, CD38−, sIg−, CD77−, CD23+, CD40 bright). This study not only suggests a role for TIMP-1 in BLs, but also supports its value as a prognostic factor. This is a US government work. There are no restrictions on its use.
Predicting the strength of UP-elements and full-length E. coli σE promoters (2011)

Predicting the location and strength of promoters from genomic sequence requires accurate sequenced-based promoter models. We present the first model of a full-length bacterial promoter, encompassing both upstream sequences (UP-elements) and core promoter modules, based on a set of 60 promoters dependent on σ(E), an alternative ECF-type σ factor. UP-element contribution, best described by the length and frequency of A- and T-tracts, in combination with a PWM-based core promoter model, accurately predicted promoter strength both in vivo and in vitro. This model also distinguished active from weak/inactive promoters. Systematic examination of promoter strength as a function of RNA polymerase (RNAP) concentration revealed that UP-element contribution varied with RNAP availability and that the σ(E) regulon is comprised of two promoter types, one of which is active only at high concentrations of RNAP. Distinct promoter types may be a general mechanism for increasing the regulatory capacity of the ECF group of alternative σ's. Our findings provide important insights into the sequence requirements for the strength and function of full-length promoters and establish guidelines for promoter prediction and for forward engineering promoters of specific strengths.
Current reused Colpitts VCO and frequency divider with quadrature outputs (2011)

A low power current reused Colpitts VCO and divide-by-two circuit is proposed in 0.18µm CMOS technology. The divider is stacked on top of a common drain gm-boosted differential Colpitts VCO to share DC current. A capacitance neutralization technique is used to compensate the miller effect of the parasitic gate-drain capacitance Cgd in the VCO, and improves the generated negative resistance and phase noise performance. The Colpitts VCO works at 4.293-4.513GHz, and can provide 2.147-2.257GHz quadrature outputs through the stacked divide-by-two circuit. The VCO circuit exclude the output buffer consumes 2.8mA at 1.8V supply voltage. The measured phase noise is -109dBc/Hz at 1MHz offset frequency when the VCO output is 4.513GHz.
Statistical Deconvolution for Superresolution Fluorescence Microscopy (2012)

Superresolution microscopy techniques based on the sequential activation of fluorophores can achieve image resolution of ∼10 nm but require a sparse distribution of simultaneously activated fluorophores in the field of view. Image analysis procedures for this approach typically discard data from crowded molecules with overlapping images, wasting valuable image information that is only partly degraded by overlap. A data analysis method that exploits all available fluorescence data, regardless of overlap, could increase the number of molecules processed per frame and thereby accelerate superresolution imaging speed, enabling the study of fast, dynamic biological processes. Here, we present a computational method, referred to as deconvolution-STORM (deconSTORM), which uses iterative image deconvolution in place of single- or multiemitter localization to estimate the sample. DeconSTORM approximates the maximum likelihood sample estimate under a realistic statistical model of fluorescence microscopy movies comprising numerous frames. The model incorporates Poisson-distributed photon-detection noise, the sparse spatial distribution of activated fluorophores, and temporal correlations between consecutive movie frames arising from intermittent fluorophore activation. We first quantitatively validated this approach with simulated fluorescence data and showed that deconSTORM accurately estimates superresolution images even at high densities of activated fluorophores where analysis by single- or multiemitter localization methods fails. We then applied the method to experimental data of cellular structures and demonstrated that deconSTORM enables an approximately fivefold or greater increase in imaging speed by allowing a higher density of activated fluorophores/frame.
Important Regulatory Role of Activated Platelet-Derived Procoagulant Activity in the Propagation of Thrombi Formed Under Arterial Blood Flow Conditions (2009)

Background: The functional links between the activation of platelets and the coagulation system have not been clarified. Methods and Results: Immobilized collagen fibrils were perfused with human blood containing fluoresceinated platelets in the presence of various concentrations of thrombin inhibitor. Coagulant activity around platelet thrombi was detected using a FITC-conjugated antibody against the fibrin monomer complex (F-405). Intra-cytosolic calcium ion concentrations ([Ca2+]i) in individual platelets and the volume of thrombi were detected with an ultrafast confocal laser microscope equipped with a piezo-motor control unit. The volume of platelet thrombi formed after 8 min of blood perfusion in the presence of 10, 25, 50, and 100 μmol/L argatroban was 7.69±0.46 μm3, 6.61±1.96 μm3, 3.63±1.54 μm3, and 1.67±0.75 μm3, respectively. There was a positive correlation between the volume of platelet thrombi and the amount of fibrin monomer complex produced around them. The [Ca2+]i of the platelets forming the thrombi oscillated between a minimum of 92.0±57.4 nmol/L, 120.1±68.1 nmol/L, and a maximum of 217.6±131.5 nmol/L, 367.6±189.1 nmol/L, respectively, in the presence of 100 and 10 μmol/L argatroban. Conclusions: The results suggest a crucial role of coagulant activity in both the generation of fibrin and the growth of platelet thrombi. (Circ J 2009; 73: 540 - 548)
Immunological studies of the human placenta: functional and morphological analysis of pregnancy-associated plasma protein A (PAPP-A). (1981)

A blood protein, pregnancy-associated plasma protein A (PAPP-A), has been isolated from the plasma of pregnant women. An antiserum to this protein has been prepared and used to localize the protein within the placenta by immunofluorescence. It was found to be inconstantly present in the syncytiotrophoblast and intervillous fibrin. Neither antiserum nor antigen exerts a cytotoxic effect on peripheral blood lymphocytes, and neither affected blastogenic responses of lymphocytes to mitogens or in mixed lymphocyte culture reactions.
Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation (2001)

Recently Toll-like receptors (TLRs) have been found to be involved in cellular activation by microbial products, including lipopolysaccharide, lipoproteins, and peptidoglycan. Although for these ligands the specific transmembrane signal transducers TLR-4, TLR-2, or TLR-2 and -6 have now been identified, the molecular basis of recognition of lipoteichoic acids (LTAs) and related glycolipids has not been completely understood. In order to determine the role of TLRs in immune cell activation by these stimuli, experiments involving TLR-2-negative cell lines, TLR-expression plasmids, macrophages from TLR-4-deficient C3H/HeJ-mice, and inhibitory TLR-4/MD-2 antibodies were performed. Glycolipids from Treponema maltophilum and Treponema brennaborense, as well as highly purified LTAs from Staphylococcus aureus and Bacillus subtilis exhibited TLR-2 dependence in nuclear factor kappaB activation and cytokine induction; however, T. brennaborense additionally appeared to signal via TLR-4. Fractionation of the T. brennaborense glycolipids by hydrophobic interaction chromatography and subsequent cell stimulation experiments revealed two peaks of activity, one exhibiting TLR-2-, and a second TLR-4-dependence. Furthermore, we show involvement of the signaling molecules MyD88 and NIK in cell stimulation by LTAs and glycolipids by dominant negative overexpression experiments. In summary, the results presented here indicate that TLR-2 is the main receptor for Treponema glycolipid and LTA-mediated inflammatory response.
Multiomics Data Collection, Visualization, and Utilization for Guiding Metabolic Engineering (2021)

Biology has changed radically in the past two decades, growing from a purely descriptive science into also a design science. The availability of tools that enable the precise modification of cells, as well as the ability to collect large amounts of multimodal data, open the possibility of sophisticated bioengineering to produce fuels, specialty and commodity chemicals, materials, and other renewable bioproducts. However, despite new tools and exponentially increasing data volumes, synthetic biology cannot yet fulfill its true potential due to our inability to predict the behavior of biological systems. Here, we showcase a set of computational tools that, combined, provide the ability to store, visualize, and leverage multiomics data to predict the outcome of bioengineering efforts. We show how to upload, visualize, and output multiomics data, as well as strain information, into online repositories for several isoprenol-producing strain designs. We then use these data to train machine learning algorithms that recommend new strain designs that are correctly predicted to improve isoprenol production by 23%. This demonstration is done by using synthetic data, as provided by a novel library, that can produce credible multiomics data for testing algorithms and computational tools. In short, this paper provides a step-by-step tutorial to leverage these computational tools to improve production in bioengineered strains.
Myricetin ameliorates high glucose‐induced endothelial dysfunction in human umbilical vein endothelial cells (2019)

Endothelial dysfunction is recognized as the initial detectable stage of cardiovascular disease, a serious complication of diabetes. In this study, we evaluated effects of myricetin on high glucose (HG)-elicited oxidative damage in human umbilical vein endothelial cells (HUVECs). The cells were pre-incubated with myricetin and then treated with HG to induce apoptosis. The effect of myricetin on viability was investigated by MTT assay. The levels of lipid peroxidation (LPO) were determined by thiobarbituric acid (TBA) method. The protein expression of Bax, Bcl-2 and caspase-3 was measured by western blot analysis. Moreover, the effect of myricetin on total antioxidant capacity (TAC) and total thiol molecules was also determined. Our results showed that myricetin was able to markedly restore the viability of endothelial cells under oxidative stress. Myricetin reduced HG-caused increase in LPO levels. Also, TAC and total thiol molecules were notably elevated by myricetin. Incubation with myricetin decreased the protein expression levels of Bax, whereas it increased the expression levels of the Bcl-2, compared with HG treatment alone. Furthermore, myricetin significantly decreased cleaved caspase-3 protein expression. It is concluded that myricetin may protect HUVECs from oxidative stress induced by HG via increasing cell TAC and reducing Bax/Bcl-2 protein ratio, and caspase-3 expression.
Analysis of a Segmented Brushless PM Machine Utilising Soft Magnetic Composites (2007)

Soft magnetic composites (SMC) is a magnetic material which offers the potential for innovative machine geometries and lower cost manufacturing. This paper examines the finite-element analysis and performance prediction of a segmented brushless permanent magnet machine based on SMC. Experimental results including the back-EMF waveform, iron loss and performance characteristics are used to validate the simulation results.
Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex (2008)

Ribonuclease HI (RNase H) is a member of the nucleotidyl-transferase superfamily and endo-nucleolytically cleaves the RNA portion in RNA/DNA hybrids and removes RNA primers from Okazaki fragments. The enzyme also binds RNA and DNA duplexes but is unable to cleave either. Three-dimensional structures of bacterial and human RNase H catalytic domains bound to RNA/DNA hybrids have revealed the basis for substrate recognition and the mechanism of cleavage. In order to visualize the enzyme's interactions with duplex DNA and to establish the structural differences that afford tighter binding to RNA/DNA hybrids relative to dsDNA, we have determined the crystal structure of Bacillus halodurans RNase H in complex with the B-form DNA duplex [d(CGCGAATTCGCG)](2). The structure demonstrates that the inability of the enzyme to cleave DNA is due to the deviating curvature of the DNA strand relative to the substrate RNA strand and the absence of Mg(2+) at the active site. A subset of amino acids engaged in contacts to RNA 2'-hydroxyl groups in the substrate complex instead bind to bridging or non-bridging phosphodiester oxygens in the complex with dsDNA. Qualitative comparison of the enzyme's interactions with the substrate and inhibitor duplexes is consistent with the reduced binding affinity for the latter and sheds light on determinants of RNase H binding and cleavage specificity.
Logical modeling of temporal data (1987)

In this paper we examine the semantics and develop constructs for temporal data independent of any traditional data model, such as the relational or network data models. Unlike many other works which extend existing models to support temporal data, our purpose is to characterize the properties of temporal data and operators over them without being influenced by traditional models which were not specifically designed to model temporal data. We develop data constructs that represent sequences of temporal values, identify their semantic properties, and define operations over these structures.
Initial clinical studies with 5-iodo-2'-deoxyuridine. (1961)

Summary The results of preliminary clinical pharmacological investigations of 5-iodo-2′-deoxyuridine (IUDR), an analog of thymidine, are reported. With dosages of 100–120 mg IUDR/kg, infused intravenously during periods of 2–3 hours daily for 5 or 6 days, studies of the urinary excretion of IUDR, 5-iodouracil, and iodide indicated that significant blood levels of IUDR were maintained for approximately 4 hours. The major toxic effects of such dosage regimens were stomatitis, leukopenia, and alopecia. In the present series, evidence of modest tumor inhibition was observed in six of sixteen patients with advanced neoplastic disease. Possible areas for future investigations with this compound, particularly in combination with other antimetabolites and radiation therapy, have been discussed.
A calibration procedure and testing of MEMS inertial sensors for an FPGA-based GPS/INS system (2010)

Given the burgeoning demand for a small, lightweight, consume very little power, low-cost high performance inertial Measurement Units(IMU), test methods are necessary to evaluate the current state of the available of Micro-Electro-Mechanical Systems(MEMS) technology. A reliable and efficient calibration and testing method for evaluating the performance of MEMS IMU is developed, by virtue of MEMS sensor suffering from various errors that have to be calibrated and accomplished to get acceptable navigation results. A prototype development board based on FPGA, dual core processor's configuration for IMU/INS/GPS integrated navigation system is designed for experimental tests. According to the MEMS IMU developed, static tests, rate tests, thermal tests are implemented to estimate the deterministic error such as bias, scale factor, and non-orthogonality. Allan variance method is used to characterize the stochastic noise in inertial sensor. Experimental results are afforded and evaluated.
The Jewish Year Book 5711–12, 1 January to 31 December 1951 (1951)

The Jewish Year Book 5711–12, 1 January to 31 December 1951 Get access The Jewish Year Book 5711–12, 1 January to 31 December 1951. London, Jewish Chronicle, 1951. 509 pp. Index. 7½″ × 5″. 10s. George Kirk George Kirk Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 27, Issue 3, July 1951, Page 409, https://doi.org/10.2307/2606547 Published: 01 July 1951
A low phase noise C-band frequency synthesizer using a new fractional-N PLL with programmable fractionality (1996)

This paper presents a new fractional-N PLL that has an arbitrary denominator of the fractional division ratio as well as an arbitrary numerator and an integer part. This enables a reduction in the phase noise of frequency synthesizers for many applications with various channel-space frequencies. The circuit elements of this fractional-N PLL are fabricated in LSI's that operate up to 6.5 GHz. They have been successfully installed in a C-band frequency synthesizer with a low phase noise MMIC VCO.
Studies on the Structure and Biosynthesis of Tridentoquinone and Related Meroterpenoids from the Mushroom <i>Suillus tridentinus</i> (Boletales) (2007)

Abstract Tridentoquinone ( 1 ), the main pigment of Suillus tridentinus , is accompanied by the known meroterpenoid bolegrevilol ( 3 ) and a dimer, tridentorubin ( 5 ). The absolute configuration of 1 was unambiguously established by a single‐crystal X‐ray analysis of the corresponding (–)‐camphanoate. The structure of 5 was elucidated by 2D NMR techniques including a 2D INADEQUATE experiment. Feeding experiments with [1‐ 13 C]‐labeled 4‐hydroxybenzoic acid ( 6* ) and 3,4‐dihydroxybenzoic acid ( 7* ) proved the incorporation of these precursors into all three metabolites. Tridentoquinone ( 1 ) was monolabeled at C‐1 suggesting the formation of the ansa ring by oxidative cyclisation of 2‐geranylgeranyl‐6‐hydroxybenzoquinone ( 10 ). This was supported by the isolation of the expected intermediate, deoxytridentoquinone ( 11 ), from the mushroom extract. Tridentorubin ( 5 ) may be formed by addition of precursor 10 to tridentoquinone ( 1 ). This hypothesis is backed up by the in vitro formation of an analogous product 13 from 1 and 1,4‐benzoquinone. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)