gebhart/patrepeval huggingface dataset:
miRNA expression profiling in cancer cell lines and tumor samples using LNA™ oligonucleotide arrays (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4170 

MicroRNAs (miRNAs) are a recently recognized class of evolutionarily conserved riboregulators. miRNAs are 21- 22 nucleotides in length and derived from longer precursors. The mature miRNAs function within large complexes to negatively regulate specific target mRNAs. In animals most miRNAs have an imprecise complementarity to their target mRNAs; basepairing with its target sequence - often in the 3’ UTR - results in translational repression. The functional significance of most miRNAs is still unknown as is their involvement in disorders like cancer. The aim of our studies is to determine miRNA expression in cancer cell lines and in series of clinically well-annotated tumor samples and to eventually examine the role of aberrantly expressed miRNAs for the pathogenesis of cancer. Oligonucleotide arrays were developed in which Tm normalized, locked nucleic acid (LNA™) capture probes are used for the detection of the full complement of human/mouse miRNAs as registered and annotated in the miRNA registry ( ). The spotting conditions of the NH2-C6 modified linker with LNA™ capture probes attached, including perfect match and single mismatch oligonucleotides, were determined as were the optimal hybridization and washing conditions. In addition we tested several total RNA and miRNA labeling tech niques including the ULS™-labeling technology (Kreatech Biotechnology) and T4 RNA ligase based methods. We present data on the development, validation and use of these arrays (miRCURY™ arrays) for miRNA expression profiling of cancer cell lines, including chemotherapeutic sensitive and resistant cell lines, as well as samples of breast and lung cancer. Investigated will be whether individual miRNAs or miRNA profiles correlate with important clinical and prognostic parameters such as tumor type, tumor stage, response to chemotherapy, overall and disease free survival. Special attention will be given to the expression of the let-7 family of miRNAs - measured by Northern blotting and quantitative RT-PCR - in non-small cell lung cancer samples and corresponding normal lung tissue in relation to the expression levels of the RAS oncogene.
Dissection of salicylic acid-mediated defense signaling networks (2009)

The small phenolic molecule salicylic acid (SA) plays a key role in plant defense. Significant progress has been made recently in understanding SA-mediated defense signaling networks. Functional analysis of a large number of genes involved in SA biosynthesis and regulation of SA accumulation and signal transduction has revealed distinct but interconnecting pathways that orchestrate the control of plant defense. Further studies utilizing combinatorial approaches in genetics, molecular biology, biochemistry and genomics will uncover finer details of SA-mediated defense networks as well as further insights into the crosstalk of SA with other defense signaling pathways. The complexity of defense networks illustrates the capacity of plants to integrate multiple developmental and environmental signals into a tight control of the costly defense responses.
Short convolutional codes with maximal free distance for rates 1/2, 1/3, and 1/4 (Corresp.) (1973)

This paper gives a tabulation of binary convolutional codes with maximum free distance for rates <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\frac{1}{2}, \frac{1}{3}</tex> , and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\frac{1}{4}</tex> for all constraint lengths (measured in information digits) <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> up to and including <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nu = 14</tex> . These codes should be of practical interest in connection with Viterbi decoders.
Query2Vec: An Evaluation of NLP Techniques for Generalized Workload Analytics (2018)

We consider methods for learning vector representations of SQL queries to support generalized workload analytics tasks, including workload summarization for index selection and predicting queries that will trigger memory errors. We consider vector representations of both raw SQL text and optimized query plans, and evaluate these methods on synthetic and real SQL workloads. We find that general algorithms based on vector representations can outperform existing approaches that rely on specialized features. For index recommendation, we cluster the vector representations to compress large workloads with no loss in performance from the recommended index. For error prediction, we train a classifier over learned vectors that can automatically relate subtle syntactic patterns with specific errors raised during query execution. Surprisingly, we also find that these methods enable transfer learning, where a model trained on one SQL corpus can be applied to an unrelated corpus and still enable good performance. We find that these general approaches, when trained on a large corpus of SQL queries, provides a robust foundation for a variety of workload analysis tasks and database features, without requiring application-specific feature engineering.
Use of Prostaglandin E <sub>2</sub> for Therapeutic Abortion (1970)

Termination of pregnancy was attempted with intravenous infusion of prostaglandin E(2) (5 mug./minute) in 52 consecutive cases. Abortion was successful in 50 of these and complete in 43. There were no serious side-effects.
Construction and Characteristics of Evaporated Nickel Bolometers (1947)

Details are given of the construction of an evaporated nickel bolometer. These bolometers are approximately 200A thick and are evaporated onto a nitrocellulose pellicle approximately 1000A thick. The pellicle is supported on a glass base in which is a sandblasted groove. This groove is immediately below the area of the pellicle which is covered with the bolometer strip. The techniques are described which were used to measure the bolometer characteristics. The sensitivity and frequency response of the bolometer are discussed. A typical bolometer has a time constant of 0.004 second, and a threshold of 3.3×10−8 watt for radiation modulated sinusoidally at 30 cycles per second where the band width of the system is 100 cycles.
Modelling, simulation and control of photovoltaic converter systems (1998)

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University.
Synthesis, p38 Kinase Inhibitory and Anti-inflammatory Activity of New Substituted Benzimidazole Derivatives (2012)

P38 mitogen activated protein kinases have been found to involve in the production and release of unwarranted levels of pro-inflammatory cytokines including TNFα and IL-1β in numerous inflammatory diseases. A new series of molecules, 5-substituted benzoylamino-2-substituted phenylbezimidazoles has been synthesized from 4-nitro-1, 2- diaminobenzene. The synthesized compounds were characterized by FTIR, 1HNMR and Mass. The final compounds were screened for in vitro p38 kinase inhibitory and in vivo anti-inflammatory activity. Three compounds from the series demonstrated nearly 50% inhibition of p38 kinase in the in vitro screening method at 10 μM concentration and two molecules exhibited greater than 75% inhibition of paw oedema volume during the first hour. The docking study of synthesized molecule revealed a new binding pose in ATP binding pocket.
Disorders of Blood Viscosity (1993)

In clinical situations associated with disturbed blood flow, the primary focus is usually on improving cardiovascular performance. However, during recent decades, both basic science and clinical literature reports have presented evidence that the flow properties of blood must also be considered in these situations. Thus, the relatively new fields of haemorheology and clinical haemorheology have evolved; the former deals with the flow and deformation behaviour of blood, plasma and the formed elements of blood, whereas the latter relates to alterations of their behaviour in various pathophysiologic states. This review therefore summarizes some of the salient aspects of clinical haemorheology and of the determinants of blood flow properties (flow rate, haematocrit, plasma viscosity, red cell aggregation, red cell deformability). In addition, it briefly describes several clinical disorders associated with abnormal blood, plasma or cell rheology ('hyperviscosity syndromes' occurring in polycythaemia, leukaemia, sickle cell disease, paraproteinaemias).
Long‐term survivors after gamma knife radiosurgery for brain metastases (2005)

Although the expected survival of patients with brain metastases may be limited, selected patients with effective intracranial and extracranial care for malignant disease can have prolonged, good-quality survival. The extent of extracranial disease at the time of radiosurgery was predictive of outcome, but this does not necessarily mean that patients cannot live for years if treatment is effective.
30 GHz picosecond pulse generation from actively mode-locked erbium-doped fibre laser (1990)

Ultrafast picosecond optical pulse generation by harmonic mode-locking of an erbium-doped fibre ring laser is successfully demonstrated. A Ti:LiNbO3 electro-optical modulator driven by a 15 GHz RF signal is used as the mode-locker. Transform-limited pulses with a duration of 7.6 ps arc achieved at a repetition rate of 30 GHz.
Memory efficient IFFT design for OFDM-based applications (2013)

In this paper, we propose a new memory efficient IFFT design method for OFDM-based applications, based on a signed integer mapping of three IFFT input signals which are composed of modulated data, pilot and null signals. The proposed method focuses on reducing the word size of memory in the first two stages of the single-path delay feedback (SDF) IFFT architectures since the first two stages require 75% of the overall memory. By Synopsys simulation of the first two stages of IFFT, it is shown that the proposed method achieves about 40% reduction in area and 44% reduction in power consumption compared with the previous work.
A self-supervised learning system for object detection using physics simulation and multi-view pose estimation (2017)

Progress has been achieved recently in object detection given advancements in deep learning. Nevertheless, such tools typically require a large amount of training data and significant manual effort to label objects. This limits their applicability in robotics, where solutions must scale to a large number of objects and variety of conditions. This work proposes an autonomous process for training a Convolutional Neural Network (CNN) for object detection and pose estimation in robotic setups. The focus is on detecting objects placed in cluttered, tight environments, such as a shelf with multiple objects. In particular, given access to 3D object models, several aspects of the environment are physically simulated. The models are placed in physically realistic poses with respect to their environment to generate a labeled synthetic dataset. To further improve object detection, the network self-trains over real images that are labeled using a robust multi-view pose estimation process. The proposed training process is evaluated on several existing datasets and on a dataset collected for this paper with a Motoman robotic arm. Results show that the proposed approach outperforms popular training processes relying on synthetic - but not physically realistic - data and manual annotation. The key contributions are the incorporation of physical reasoning in the synthetic data generation process and the automation of the annotation process over real images.
Identification and significance of glucokinase in transplantable insulinomas. (1983)

Glucose 6-phosphotransferases were investigated in two transplantable rat insulinoma tumor lines. Homogenates of tumors contained glucose phosphorylating activities of both high (e.g. supernatant Km = 0.060 mM and pellet Km = 0.077 mM) and low (Km = 7.6 mM) affinities for glucose. Chromatography of supernatants (105,000 X g) of insulinomas on DEAE-Cibacron Blue F3GA agarose evidenced glucose 6-phosphotransferase activity which eluted similarly to glucokinase from rat liver. Kinetic studies of insulinoma glucokinase also indicated similarity with liver glucokinase, i.e. cooperative rate dependence on glucose concentration and comparable Km values for glucose, and it did not phosphorylate N-acetylglucosamine. These characteristics of glucose 6-phosphotransferase in insulinomas are similar to those of the enzyme found in islets of Langerhans. Since glucokinase is thought to serve as glucose sensor of insulin secretory pancreatic beta-cells, these transplantable insulinomas offer great promise for biochemical and biophysical studies of the nature of glucose-induced insulin release.
Individuals Identification Based on Palm Vein Matching under a Parallel Environment (2019)

Biometric identification and verification are essential mechanisms in modern society. Palm vein recognition is an emerging biometric technique, which has several advantages, especially in terms of security against forgery. Contactless palm vein systems are more suitable for real-world applications, but two of the major challenges of the state-of-the-art contributions are image deformations and time efficiency. In the present work, we propose a new method for palm vein recognition by combining DAISY descriptor and the Coarse-to-fine PatchMatch (CPM) algorithm in a parallel matching process. Our proposal aims at providing an effective and efficient technique to obtain similarity of palm vein images considering their displacements as discriminatory information. Extensive evaluation on three publicly available databases demonstrates that the discriminability of the proposed approach reaches the state-of-the-art results while it is considerably superior in time efficiency.
Autumn: Arundel Park (1955)

Autumn: Arundel Park Get access Margaret Willy Margaret Willy Search for other works by this author on: Oxford Academic Google Scholar English: Journal of the English Association, Volume 10, Issue 60, Autumn 1955, Pages 234-b–235, https://doi.org/10.1093/english/10.60.234-b Published: 01 October 1955
Cytoplasmic lipid bodies of human eosinophils. Subcellular isolation and analysis of arachidonate incorporation. (1991)

Lipid bodies are non-membrane-bound cytoplasmic inclusions that are prominent in leukocytes engaged in inflammatory responses. As demonstrated by electron microscopic autoradiography, lipid bodies can serve as intracellular sites of 3H-arachidonic acid localization in eosinophils and other cells. To evaluate the role of lipid bodies as stores of esterified arachidonate, subcellular fractionation of lipid-body-rich human eosinophils was used to isolate lipid bodies free of other organelles. In lipid bodies isolated from 3H-arachidonate-labeled eosinophils, 3H-arachidonate was esterified almost totally in glycerolipids, predominantly in classes of phospholipids, including phosphatidyl-inositol and phosphatidylcholine. Lipid bodies, especially in leukocytes participating in inflammation, could represent intracellular sources of esterified arachidonate available for eicosanoid formation.
Prophecy and Ethics: Isaiah and the Ethical Tradition of Israel. By Eryl W. Davies. JSOT Supplement Series 16. Sheffield, JSOT Press, 1981. Pp. 184. £895. (1984)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Leukemia Inhibitory Factor Enhances Bone Formation in Calvarial Bone Defect (2000)

For bone defect reconstruction, locally administered cytokine plasmid was examined. Leukemia inhibitory factor (LIF) can bind to the osteoblast cell surface and induce bone formation both in vitro and in vivo. The authors investigated the local mouse LIF complementary deoxyribonucleic acid (cDNA) plasmid in the pcDNA 3 expression vector, which is promoted by cytomegalovirus and is stabilized by bovine growth hormone polyadenylation, with a gelatin sponge carrier. A total of 150 male Wistar rats were used. They were divided into three groups. Group 1 (N = 30) was treated with the gelatin carrier of the pcDNA 3 vector, group 2 (N = 90) was treated with three different doses of LIF cDNA (0.1, 1, and 10 micrograms) in the pcDNA 3-vector plasmid along with the gelatin carrier, and group 3 (N = 30) was treated with recombinant human bone morphogenetic protein -2. Ten animals in each group were euthanized at 1, 3, and 5 weeks postoperatively. Animals treated with LIF cDNA showed significantly enhanced bone mineral density (p < 0.05), as confirmed by dual-energy X-ray absorptiometry (DEXA), in 3 weeks compared with the control vehicle. By 3 weeks, the number of fibroblast-like cells and collagen fibers decreased, whereas the osteoblast-like cells increased inversely, as revealed during histological examination. LIF messenger ribonucleic acid demonstrated by in situ hybridization was observed most markedly in osteocytes of the LIF cDNA-treated group. Also, LIF peptide was detected in the same cell type by immunohistochemistry. Locally administered LIF cDNA plasmid in a gelatin carrier can increase bone density significantly, with subsequent bone formation, probably via osteocyte activation.
Microprocessor Design (2006)

Gain a Working Knowledge of the Entire Microprocessor Design Flow

This unique step-by-step guide is a complete introduction to modern microprocessor design, explained in simple nontechnical language without complex mathematics. An ideal primer for those working in or studying the semiconductor industry, Microprocessor Design explains all the key concepts, terms, and acronyms needed to understand the steps required to design and manufacture a microprocessor.

Developed from a successful corporate training course, this hands-on learning guide walks readers through every step of microprocessor design. You'll follow a new processor product from initial planning through design to production. In Microprocessor Design, the author converts his real-world design and teaching experience into an easy-to-follow reference employing an on-the-job-training approach to cover: 
The evolution of microprocessors Microprocessor design planning Architecture and microarchitecture Logic design and circuit design Semiconductor manufacturing Processor packaging and test

This authoritative reference is an excellent introduction for students or engineers new to processor design and can show industry veterans how their specialty fits into the overall design flow. This accessible and practical guide will provide the reader with a broad working knowledge of the concepts of microprocessor design, as well as an understanding of the individual steps in the process and the jargon used by the industry.

Table of contents

Chapter 1: The Evolution of the Microprocessor
Chapter 2: Computer Components
Chapter 3: Design Planning
Chapter 4: Computer Architecture
Chapter 5: Microarchitecture
Chapter 6: Logic Design
Chapter 7: Circuit Design
Chapter 8: Layout
Chapter 9: Semiconductor Manufacturing
Chapter 10: Microprocessor Packaging
Chapter 11: Silicon Debug and Test
GLOSSARY
INDEX
Kinetics of papain-catalyzed hydrolysis of α-N-benzoyl-L-arginine-p-nitroanilide (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of papain-catalyzed hydrolysis of α-N-benzoyl-L-arginine-p-nitroanilideJohn E. Mole and H. Robert HortonCite this: Biochemistry 1973, 12, 5, 816–822Publication Date (Print):February 27, 1973Publication History Published online1 May 2002Published inissue 27 February 1973https://pubs.acs.org/doi/10.1021/bi00729a005https://doi.org/10.1021/bi00729a005research-articleACS PublicationsRequest reuse permissionsArticle Views681Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
4‐Amino‐thiazole (1967)

Abstract Das aus Xanthanwasserstoff bzw. Cyanamid und Schwefelkohlenstoff erhältliche Cyanamido‐dithiocarbonat reagiert mit Halogenessigsäurederivaten sowie mit Chlormethylketonen unter S‐Alkylierung und gleichzeitiger Cyclisierung zu 4‐Aminothiazolderivaten. In gleicher Weise sind, ausgehend von Cyanamid und Isothiocyanaten über die Cyanamido‐thiocarbamate – deren Isolierung nicht notwendig ist – subst. 2,4‐Diamino‐thiazole zugänglich.
Differential immunogenic expression of an H-2-linked histocompatibility antigen on different tissues. Differences in survival between heart, thyroid, and skin allografts. (1979)

A comparative study of allograft reaction against heart, thyroid, and skin allografts was performed using inbred congenic mouse strains. Neonatal hearts were grafted into pinna of the mouse ear, adult thyroid glands were transplanted under the kidney's capsule, and pieces of adult skin were grafted orthotopically on the dorsal side of the recipient mice. A specific mouse strain combination was chosen to serve as donors and recipients for the transplants, namely, the C57BL/6 (H-2b) and the mutant strain B6.C-H(Z1) (H-21ba), which differs in a point mutation in the K or IA region of the major histocompatibility complex. In this strain combination, an acute skin graft rejection takes place without the production of antibodies. Reciprocal skin grafts performed between C57BL/6 and B6.C-H(Z1) mice are rejected within 12 to 15 days post-transplantation, similar to the time required for the rejection of skin grafts incompatible at multiple histocompatibility loci. In contrast, neonatal cardiac transplants from C57BL/6 donors grafted to B6.C-H(Z1) recipients and vice versa were exempted from immune injury even 40 days after the transplantation, and similar results were obtained using adult thyroid transplants. Thyroid and cardiac allografts incompatible at multiple histocompatibility loci were rejected within 8 and 15 days post-transplantation, respectively. We discuss the unique antigenic characteristics of heart and thyroid grafts versus skin grafts and the possible involvement of different immune mechanisms which may explain the survival of heart and thyroid transplants compared with skin grafts.