gebhart/patrepeval huggingface dataset:
Heck coupling of haloaromatics with octavinylsilsesquioxane: solution processable nanocomposites for application in electroluminescent devices (2005)

A new solution processable nanocomposite material has been prepared via the Heck coupling of octavinylsilsesquioxane with a selected bromoaromatic hole transport compound. Resultant electroluminescent devices show an 18% improvement in external quantum efficiencies over their small molecule analogues.
Metformin Induces a Senescence-associated Gene Signature in Breast Cancer Cells (2013)

Diabetic patients taking metformin have lower incidence of breast cancer than those taking other anti-diabetic medications. Additionally, triple negative breast cancer (TNBC), a form of breast cancer disproportionately afflicting premenopausal African American women, shows atypical susceptibility to metformin's antiproliferative effect. The mechanisms involved in metformin's function in TNBC has not yet been fully elucidated. Therefore, we sought to identify pathways regulated by metformin in using the MDA-MB-468 TNBC cell model. Metformin dose-dependently caused apoptosis, decreased cell viability, and induced cell morphology/chromatin condensation consistent with the permanent proliferative arrest. Furthermore, gene expression arrays revealed that metformin caused expression of stress markers DDIT3, CYP1A1,and GDF-15 and a concomitant reduction in PTGS1 expression. Our findings show that metformin may affect the viability and proliferative capacity of TNBC by inducing an antiproliferative gene signature, and that metformin may be effective in the treatment/prevention of TNBC.
Combined use of Lactobacillus reuteri and soygerm powder as food supplement (2001)

The interactions between the Lactobacillus strain and soygerm powder suggest that combining both in fermented milk can exhibit advantageous probiotic effects. The relevance of the combination of the strain and the soygerm powder should be studied under more relevant physiological conditions.
Comparison of a Mobile Technology Application With the Balance Error Scoring System (2014)

Context: The most widely used method for postural balance assessment relies on the subjective observations of a test administrator. Accelerometry has been shown to provide a valid and reliable method for assessment of balance, and recent advances in microelectromechanical systems have made the technology available in mobile electronic devices. Objective: To compare a mobile technology application with a commonly used subjective balance assessment. Setting: Biomechanics laboratory. Participants: Twenty-one nonathlete college-aged individuals (7 men, 14 women; mean age 23 ± 3 years) volunteered to participate. Subjects were excluded if they reported any preexisting condition that might affect postural balance. Results: A strong inverse correlation was found between the scores for the two balance assessment methods ( r = -.767, p < .01). Conclusions: Advances in technology have provided an attractive means to objectively quantify postural balance with off-the-shelf mobile consumer electronic devices.
A quantitative analysis of single pulse ultraviolet dry laser cleaning (1999)

Particles as small as 0.3 μm in diameter have been successfully removed from a glass surface using a single ultraviolet pulse from a frequency doubled copper vapor laser (255.3 nm). Quantitative analysis of the particle density before and after laser irradiation shows that laser cleaning occurs after a fluence threshold is reached. The cleaning efficiency after threshold follows a nonlinear trend with respect to fluence. A model is presented which reveals that the cleaning efficiency is a function of the irradiance distribution of the beam used. Results of modeling thermal expansion of the substrate and particles, and particle adhesion do not confirm a thermal expansion mechanism for laser cleaning in this study, in contrast with other recent reports.
A neural net acoustic phonetic feature extractor based on wavelets (2002)

An experimental speech processing system for extracting acoustic phonetic features from speaker independent continuous speech has been built and tested. The system uses wavelet analysis to preprocess the speech, and a two-layer receptive field neural network to recognize the phonetic features. The recognizer was implemented in software on a desktop computer, and DARPA's TIMIT CD-ROM database of continuous speech was used for both training and testing. Preliminary results, using a network trained to recognize voicing and frication, are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Cycling for Freezing of Gait (2010)

Contains fulltext : 87977.pdf (Publisher’s version ) (Open Access)
Blast Colony Forming Cell‐Binding Capacity of Bone Marrow Stroma from Myelodysplastic Patients (1996)

A specific stroma function can be quantitatively assessed by counting the stroma-adherent blast cell colonies (CFU-BL) that are formed from normal plastic nonadherent mononuclear bone marrow cells (PNAMNC) after a short-term coincubation ("panning") with the preformed stromal layer. In order to obtain information of stroma function in myelodysplasia (MDS), the "CFU-BL-binding capacity" of stroma from normal bone marrow and from patients with MDS were compared. Stromal cell cultures were established from mononuclear bone marrow cells in microplate cultures cultured with or without 10(-6) M hydrocortisone. CFU-BL-binding capacity was studied by counting blast colonies seven days after panning, and the results were expressed as CFU-BL/10(3) PNAMNC. Normal marrow stromal layers bound CFU-BL only if they were cultured with hydrocortisone, while MDS stromal layers also bound CFU-BL in the absence of hydrocortisone. For further studies of the function of MDS stroma, the effect of growth factors (stem cell factor [SCF], G-CSF, interleukin 3 [IL-3] and their combinations) on CFU-BL binding by normal or MDS stroma has also been compared. Twenty-hour incubation of the stromal layers with a standard dose (100 ng/ml) of various hemopoietic growth factors (IL-3 alone or in combination with SCF, G-CSF alone or in combination with SCF) did not have any effect on CFU-BL binding by normal marrow stroma, but increased the CFU-BL binding by stromal layers from MDS bone marrow. These findings suggest that although stromal microenvironment in MDS is capable of supporting hemopoiesis, bone marrow stroma from MDS patients differs in some characteristics from the normal stroma.
Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase (1990)

The sequence of the structural gene encoding the Legionella pneumophila extracellular zinc metalloprotease has been determined and was found to possess a single large open reading frame (ORF) of 1,629 nucleotides (nt). This ORF was preceded by consensus promoter (TTAACT . . . 17 nt . . . TATAAC) and ribosome-binding (TAAGGAG) sequences. The deduced polypeptide contained a putative signal sequence and a total of 543 amino acid residues with a computed molecular size of 60,775 daltons, substantially larger than the observed 38,000 daltons of the native and recombinant proteins. A homology search revealed extensive amino acid identity with Pseudomonas aeruginosa elastase, a protein that is also encoded by an ORF substantially larger than that predicted for the mature size of the protein. The structural identity between the L. pneumophila protease and P. aeruginosa elastase was most pronounced in the regions forming the enzymatic active site of elastase. Amino acid residues constituting the active-site cleft of elastase were greater than 75% conserved. Elastase residues that interact with and mediate proteolysis of substrate peptides were 100% conserved. Competitive inhibitors of elastase and the structurally and functionally related thermolysin (phosphoramidon and a phosphoramidate analog, Z-GlyP(O)Leu-Ala), were shown to be equally potent at inhibiting the proteolytic activity of the L. pneumophila protease. These inhibitor studies along with the amino acid sequence similarities provide strong evidence that the L. pneumophila protease and P. aeruginosa elastase share a similar molecular mechanism of proteolysis.
Effect of Linomide on Gut Immune Cell Distribution and on TNF-?? in Plasma and Ascites: An Experimental Study in the Septic Rat (2002)

A significant reduction of the pan T lymphocytes as well as CD4+ and CD8 subsets of cells in the gut mucosa of the septic rats has previously been demonstrated. In contrast, the populations of major histocompatibility complex (MHC) class II-positive cells and macrophages increased. The aim of this study was to evaluate if the immunomodulator Linomide influenced the immune cell distribution in the small intestinal mucosa in sepsis and, furthermore, if these changes coincide with changes in the concentration of tumor necrosis factor-alpha (TNF-alpha) in plasma or ascites. Polymicrobial sepsis was induced in rats by cecal ligation and puncture (CLP). Three different experimental groups were used: CLP, Linomide p.o. + CLP, and Linomide i.p.+ CLP, with adequate controls. Specimens were taken from the small bowel for immunohistologic staining and grading of mucosal injury. The following monoclonal antibodies were used: W3/25, OX8, R73, OX6, and ED1. All slides were examined by one "blinded" examiner. Mucosal injury was graded from 0 to 5. The immunostained tissues were also analyzed by an automatic color-based image system. All controls had a normal appearance of the mucosa (grade 0-1), whereas the septic animals had a median grade of III (II-IV) mucosal injury. Linomide i.p. + CLP decreased mucosal damage to median I (0-IV, P < 0.05). Linomide had no effects on the immune cell distribution in controls. In CLP rats, a significant reduction in both CD4+ and CD8+ T lymphocytes as well as an increased number of macrophages and MHC class II-positive cells was seen in the villi as compared with sham-operated controls (P < 0.05). Linomide attenuated these changes for CD8+ and T lymphocytes and macrophages. Sepsis caused increased concentrations of TNF-alpha in portal blood and ascites 3 h from CLP induction. This increase was attenuated by Linomide.
Chronic Bovine Mastitis and Milk Yield (1937)

Summary Observations on the production of animals before and after the development of laboratory evidence of mastitis were made. These data are derived from animals in the early stages of infection and animals in which the disease was latent in character. In many cases no clinical evidence was observable during most of the mastitis reacting periods. Since animals showing obvious clinical evidence of mastitis were eliminated from the herds as a matter of routine practice before the full impact of chronic mastitis on production of milk was manifested, it is evident that the full adverse effect on yield is not here measured. Rather, these data tend to show that a loss in yield may occur in the majority of cases during the incipient stage of the disease. In 240-day lactations of a group of 30 cows having a history both as mastitis free and mastitis positive based on the bromthymol blue test, the sediment test, the leucocyte count, and the shedding of organisms, there was a loss of 463 pounds of milk attributable to mastitis. In another herd of 22 cows there was a loss in yield of 425 pounds. These reductions are between 4 and 5 per cent and are not particularly significant. A loss in yield was manifested in about two thirds of the individual cases. When only one quarter was positive there was no loss in yield. Such are usually incipient stages, and possibly also compensation in yield is made by the unaffected quarters. The loss, however, increased in magnitude with each additional quarter involved amounting to about 15–20 per cent with all four quarters positive. When the results were segregated for each diagnostic test it was found that for those reacting to the bromthymol blue test the loss in yield was 837 pounds, and for those shedding S. mastiditis the loss amounted to 1100 pounds per lactation. The loss in yield of sediment positives was 596 pounds and of leucocyte positives 573 pounds. No effect on the butterfat percentage was observed.
Coplanar corporate feed effects in microstrip patch array design (1988)

The use of coplanar corporate feeds for microstrip patch arrays leads to constructional simplicity, but also to performance degradations due to feed radiation, in addition to limitations due to feed resistive loss, surface waves, mutual coupling and tolerances. These effects are quantified, and this allows specification of array performance limitations in addition to the recommendation of the use of smooth feed discontinuities, high line impedance, and thin substrates. Improvements due to the use of alternate feed geometries, such as sequentially rotated feeding and subarraying, are also quantified and are shown to be substantial.
Wearable phased arrays for sound localization and enhancement (2002)

We present the idea of a flexible phased array of microphones for wearable computers. We show how such an array can be used for both source localization and signal enhancement. As a result, it can help to solve two fundamental problems for audio input to wearables: determining who is speaking when (user commands vs. nearby speech, who is speaking in a conversation, etc.) and obtaining high-quality audio without the use of a headset microphone. We describe methods for learning the mapping between phase delays and world coordinates without specifying the array geometry and requiring minimal effort from the user. Last, we describe an implementation we have built of such an array using low-cost microphones and show some preliminary results for source localization and speaker-change detection.
Regenerative NanoOctopus Based on Multivalent-Aptamer-Functionalized Magnetic Microparticles for Effective Cell Capture in Whole Blood (2019)

Isolation of specific rare cell subtypes from whole blood is critical in cellular analysis and important in basic and clinical research. Traditional immunomagnetic cell capture suffers from suboptimal sensitivity, specificity, and time- and cost-effectiveness. Mimicking the features of octopuses, a device termed a "NanoOctopus" was developed for cancer cell isolation in whole blood. The device consists of long multimerized aptamer DNA strands, or tentacle DNA, immobilized on magnetic microparticle surfaces. Their ultrahigh sensitivity and specificity are attributed to multivalent binding of the tentacle DNA to cell receptors without steric hindrance. The simple, quick, and noninvasive capture and release of the target cells allows for extensive downstream cellular and molecular analysis, and the time- and cost-effectiveness of fabrication and regeneration of the devices makes them attractive for industrial manufacture.
Expression of the Nonmuscle Myosin Heavy Chain IIA in the Human Kidney and Screening for MYH9 Mutations in Epstein and Fechtner Syndromes (2002)

Mutations in the MYH9 gene, which encodes the nonmuscle myosin heavy chain IIA, have been recently reported in three syndromes that share the association of macrothrombocytopenia (MTCP) and leukocyte inclusions: the May-Hegglin anomaly and Sebastian and Fechtner syndromes. Epstein syndrome, which associates inherited sensorineural deafness, glomerular nephritis, and MTCP without leukocyte inclusions, was shown to be genetically linked to the same locus at 22q12.3 to 13. The expression of MYH9 in the fetal and mature human kidney was studied, and the 40 coding exons of the gene were screened by single-strand conformation polymorphism in 12 families presenting with the association of MTCP and nephropathy. MYH9 is expressed in both fetal and mature kidney. During renal development, it is expressed in the late S-shaped body, mostly in its lower part, in the endothelial and the epithelial cell layers. Later, as well as in mature renal tissue, MYH9 is widely expressed in the kidney, mainly in the glomerulus and peritubular vessels. Within the glomerulus, MYH9 mRNA and protein are mostly expressed in the epithelial visceral cells. Four missense heterozygous mutations that are thought to be pathogenic were found in five families, including two families with Epstein syndrome. Three mutations were located in the coiled-coil rod domain of the protein, and one was in the motor domain. Two mutations (E1841K and D1424N) have been reported elsewhere in families with May-Hegglin anomaly. The two others (R1165L and S96L) are new mutations, although one of them affects a codon (R1165), found elsewhere to be mutated in Sebastian syndrome.
An object-oriented framework for file systems (1992)

File systems are essential components of general purpose operating systems and are highly visible to computer users. To satisfy the growing diversity of persistent storage needs presented by application and system programs, operating systems should support both standard and customizable file systems. To facilitate the design, construction, and use of these file systems, they should fit within a general and extensible model. Currently file systems are based on one of a few common models that are neither general nor extensible. This thesis shows that a simple, general, and extensible model can be constructed by presenting an object-oriented framework that contains a few powerful persistent storage abstractions. The framework supports the characterization, design, and construction of both common file systems and experimental file systems. The object-oriented approach was chosen to exploit the techniques of data encapsulation, data abstraction, inheritance, and polymorphism.
The framework is called the Choices file system framework. It contains two fundamental abstractions: the PersistentStore class defines objects that manage the storage and retrieval of raw persistent data, and the PersistentObject class defines objects that encapsulate and provide operations on the data managed by persistent stores. Persistent stores manage data access within the file system, while various kinds of persistent objects encapsulate the organization, naming, and structure of persistent data. The framework also includes file system access classes that provide convenient interfaces to persistent objects. Using subclasses of PersistentStore and PersistentObject and several application interface classes, I and other Choices project team members have built various file systems. These file systems include some stream-oriented file systems, a record-oriented file system, a distributed file system, a persistent object store, and several special-purpose file systems.
After introducing the problems of current file system models, defining terminology, and surveying related work, this thesis presents the Choices file system framework, discusses how the framework can be extended, and describes some file systems built using the framework.
Accurate and fast discrete polar fourier transform (2004)

In this article we develop a fast high accuracy polar FFT. For a given two-dimensional signal of size N/spl times/N, the proposed algorithm's complexity is O(N/sup 2/ log N), just like in a Cartesian 2D-FFT. A special feature of our approach is that it involves only 1-D equispaced FFT's and 1D interpolations. A central tool in our approach is the pseudopolar FFT, an FFT where the evaluation frequencies lie in an over-sampled set of nonangularly equispaced points. The pseudopolar FFT plays the role of a halfway point-a nearly-polar system from which conversion to polar coordinates uses processes relying purely on interpolation operations. We describe the conversion process, and compare accuracy results obtained by unequally-sampled FFT methods to ours and show marked advantage to our approach.
Flexible Conductive Polymer Patterns from Vapor Polymerizable and Photo-Cross-Linkable EDOT (2010)

We explored direct photopatterning of a vapor polymerizable and photo-cross-linkable 3,4-ethylenedioxythiopene (EDOT) to make it suitable for use in electronics applications. We prepared a conductive polymer, PEDOT-MA, using vapor phase polymerization (VPP) of the (2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methyl methacrylate (EDOT-MA) and photochemically induced a conductivity change of the PEDOT-MA film to ensure a flexible conductive pattern. The room-temperature conductivity (σRT) of the PEDOT-MA film on PET was 30−120 S/cm, depending on the oxidant layer thickness and was increased ∼30% when the PEDOT-MA film was doped with aqueous solution of p-toluenesulfonic acid. Photoreaction of PEDOT-MA decreased the σRT to 1.7 × 10−3 S/cm because of the photo-cross-linking of the side chain. The transparency of the conductive films was tuned using the vapor polymerization time to control the film thickness. The photo-cross-linking reaction of the side chain generated micropatterns having line widths of 50−0.9 μm, in which the light-exposed areas appeared as bleached and less conductive. A diffractive, flexible, conductive film with 41% of diffraction efficiency was obtained from the line-patterned film having a spacing of 0.9 μm.
A rapidly produced 125I labelled autologous fibrinogen: in vitro properties and preliminary metabolic studies in man. (1976)

The properties of fibrinogen extracted by a precipitation method using glycine at ambient temperatures near neutral pH are described. The simple and reproducible method gives a 73% yield of high purity plasminogen-free fibrinogen in 45 minutes from small volumes of plasma. The protein extract was labelled with 125I using chloramine-T under conditions optimal for fibrinogen stability. The extraction procedure, radio-iodination, desalting, and sterilization take only 70 minutes for completion from the time donor blood is received in the laboratory. The methods, using a specially developed extraction vessel and desalting/sterilizing column, can be used in a small hospital laboratory. Autologous fibrinogen can thus be extracted from patients' blood, eliminating the risk of transmitting hepatitis when it is re-administered. The autologous material, which is 97% clottable and contains less than 0-05% free iodide, is being routinely used as a diagnostic tool in the detection of deep vein thrombosis. The high purity of the preparation facilitates metabolic studies and in vitro experimental work. In vivo results show a mean half-life in three normal volunteers of 3-95 days and a catabolic rate of 25-23% per day with the extravascular space estimated as 24-86%. In 30 surgical patients an expected reduced half-life in plasma was determined with a mean of 3-1 days.