gebhart/patrepeval huggingface dataset:
Potent Nematicidal Activity of Phthalaldehyde, Salicylaldehyde, and Cinnamic Aldehyde against Meloidogyne incognita (2013)

The nematicidal activity of selected aromatic aldehydes was tested against the root knot nematode Meloidogyne incognita. The most active aldehyde was phthalaldehyde (1) with an EC(50) value of 11 ± 6 mg/L followed by salicylaldehyde (2) and cinnamic aldehyde (3) with EC(50) values of 11 ± 1 and 12 ± 5 mg/L, respectively. On the other hand, structurally related aldehydes such as 2-methoxybenzaldehyde (21), 3,4-dimethoxybenzaldehyde, and vanillin (23) were not active at the concentration of 1000 mg/L. By liquid chromatography-mass spectrometry the reactivity of tested aldehydes against a synthetic peptide resembling the nematode cuticle was characterized. At the test concentration of 1 mM, the main adduct formation was observed for 3,4-dihydroxybenzaldehyde (22), 2-methoxybenzaldehyde (21), and 3,4-dimethoxybenzaldehyde. Considering that 2-methoxybenzaldehyde (21) and 3,4-dimethoxybenzaldehyde were not active against M. incognita in in vitro experiments led us to hypothesize a different mechanism of action rather than an effect on the external cuticle modification of nematodes. When the toxicity of the V-ATPase inhibitor pyocyanin (10) was tested against M. incognita J2 nematodes, an EC(50) at 24 h of 72 ± 25 mg/L was found. The redox-active compounds such as phthalaldehyde (1) and salicylaldehyde (2) may share a common mode of action inhibiting nematode V-ATPase enzyme. The results of this investigation reveal that aromatic redox-active aldehydes can be considered as potent nematicides, and further investigation is needed to completely clarify their mode of action.
Color transfer using scattered point interpolation (2011)

Interactive color transfer is an important image editing technique, which changes the color pattern of a given source image following users' intention and is more flexible than fully automatic methods in control of color modification. This paper presents a new interactive transfer approach which consists of two stages. Firstly, users specify the color change style by drawing some strokes in the source image and their reference strokes in one or multiple reference images. The source strokes should respectively obey the color style of their reference strokes after color transferring. This is actually a color transfer problem too, which is then casted as a quadratic optimization forcing the color statistic attributes of the source strokes to follow those of their reference strokes while preserving their gradient map unchanged. The source strokes are separately treated and therefore they can bear different color styles after processing. The solution of the optimization is very efficient due to the fact that the specified strokes with the same color style usually contains a small number of pixels. Secondly, the new colors of pixels in source strokes are propagated to the whole image automatically. Instead of solving an optimization equation, we renew the color attributes of each pixel in the source image using a scattered interpolation function which is expressed as a weighted combination of the new colors of pixels in those specified strokes, where the weight is inverse to the multiplication of the appearance distance and position distance from the current pixel to the pixel in the source strokes. Experimental results show that the proposed approach can not only preserve the texture detail and reflect user's intention well but also achieve realtime performance even for large images.
A genomic clone encoding the alpha chain of the OKM1, LFA-1, and platelet glycoprotein IIb-IIIa molecules. (1986)

LFA-1, an antigen involved in cytolytic T lymphocyte-mediated killing, and Mac-1, the receptor for complement component C3bi, constitute a family of structurally and functionally related cell surface glycoproteins involved in cellular interactions. In both mouse and man, Mac-1 (OKM1) and LFA-1 share a common 95-kDa beta subunit but are distinguished by their alpha chains, which have different cellular distributions, apparent molecular masses (165 and 177 kDa, respectively), and peptide maps. We report the isolation of a genomic clone from a human genomic library that on transfection into mouse fibroblasts produced a molecule(s) reactive with monoclonal antibodies to OKM1, to LFA-1, and to platelet glycoprotein IIb-IIIa. This gene was cloned by several cycles of transfection of L cells with a human genomic library cloned in lambda phage Charon 4A and subsequent "rescue" of the lambda phage. Transfection with the purified recombinant lambda DNA yielded a transfectant that expressed the three human alpha chains of OKM1, LFA-1, and glycoprotein IIb-IIIa, presumably in association with the murine beta chain.
In vitro and in vivo anti-B cell lymphoma activities of TRU-016 (2008)

3074 Background: TRU-016, a CD37-specific, small modular immunopharmaceutical (SMIP) compound, was designed to deplete human B cells. TRU-016 was created by humanizing SMIP-016, a mouse/human chimeric protein previously demonstrated to kill human B cells in vitro via two distinct mechanisms and have antitumor activity against human B cell tumors in xenograft models. Here we report a comparison of the activities of the chimeric and humanized molecules as well as the antitumor activity of TRU-016 in a xenograft model in which CD20- directed treatment fails. Methods: Binding of the CD37-specific molecules to B cells was determined by flow cytometry. Direct cytotoxicity mediated by the anti-CD37 molecules was assessed when cell-bound and cross-linked. ATP release or flow cytometry assays were used to measure cell viability or apoptosis. The ability of the CD37-specific molecules to promote Fc-dependent cell mediated cytotoxicity (FcDCC) was assessed by the release of 51Cr from labeled target cells incubated with human PBMC and either SMIP-016 or TRU- 016. Antitumor activity of the CD37-specific molecules was tested in immunodeficient mice bearing subcutaneous human B cell tumor xenografts and included comparison of TRU-016 and rituximab activities in a model with DOHH2 xenografts. Results: TRU-016 and SMIP-016 were indistinguishable in terms of their ability to bind to and kill CD37+ cells. In addition, TRU-016 and SMIP-016 had similar and significant antitumor activity in mice bearing Ramos or Daudi tumor xenografts. Finally, although TRU-016 and rituximab each had antitumor activity in mice bearing DOHH2 xenografts, the response was durable only in mice treated with TRU-016. Conclusions: TRU- 016, a humanized CD37-specific SMIP compound, showed significant antitumor activity against human B cell tumors in several subcutaneous xenograft models, including a model in which CD20-directed treatment failed. Therefore, TRU-016 may be a promising therapeutic agent for patients with B cell lymphoma and leukemia who fail or relapse with current standard of care. No significant financial relationships to disclose.
Experimental Vestibular Pharmacology: A Minireview with Special Reference to Neuroactive Substances and Antivertigo Drugs (1985)

Neurotransmitters and neuromodulators involved in the function of vestibular nuclei were reviewed with special reference to drugs used for treatment of motion sickness and vertigo. Biochemical, histochemical and electrophysiological studies have demonstrated that acetylcholine is a transmitter candidate from the afferent vestibular nerve to the lateral vestibular nucleus (LVN), because acetylcholine satisfies most criteria for a chemical transmitter in the central nervous system. It is unlikely, however, that monoamines such as noradrenaline, dopamine and serotonin are transmitters in the vestibular neurons, since cell bodies and nerve terminals containing the monoamines have not been detected yet in the vestibular nuclei. Although histamine and H1-receptor blockers inhibit neuron activities in the vestibular nuclei, it is unclear at present whether histaminergic system is directly related to the function of vestibular neurons. It has been established that GABA is an inhibitory transmitter from the cerebellar Purkinje cells to the LVN neurons. Diazepam is considered to enhance the GABA effect on the LVN, thereby modifying the vestibular neuronal firing. Enkephalin-containing cell bodies and nerve terminals are found in the medial vestibular nucleus, and a few substance P-containing neurons have been observed in the vestibular nuclei. However, the functional role of these peptides on the vestibular system remains to be determined. Unlike histamine H1-receptor blockers, vasodilators such as cinnarizine, ifenprodil and adenosine triphosphate, which are effective in treatment of vertigo, produce an enhancement of responsiveness of neuron activities in the vestibular nuclei, probably as a result of an increase in blood flow in the brain.(ABSTRACT TRUNCATED AT 250 WORDS)
Catalytic Copolymerization of Ethylene with Vinyl Sulfones (2010)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTCatalytic Copolymerization of Ethylene with Vinyl SulfonesCécile Bouilhac, Thomas Rünzi, and Stefan Mecking*View Author Information Chair of Chemical Materials Science, Department of Chemistry, University of Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany*Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2010, 43, 8, 3589–3590Publication Date (Web):March 25, 2010Publication History Received30 January 2010Revised18 March 2010Published online25 March 2010Published inissue 27 April 2010https://pubs.acs.org/doi/10.1021/ma100237shttps://doi.org/10.1021/ma100237srapid-communicationACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views1469Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymerization,Hydrocarbons,Monomers,Sulfones,Vinyl Get e-Alerts
Patterning the floral meristem (1998)

Flowers are reproductive structures unique to the angiosperms. Flowers, which develop from small mounds of cells called floral meristems, show a number of universal patterns such as the arrangement of organs of different type along the floral axis. However, other conserved patterns, such as floral asymmetry, are merely conserved within different subgroups. This review discusses the emerging picture of early operating developmental mechanisms, which pattern floral meristems along the radial and dorsiventral axes, and of later-acting ones, which pattern tissue differentiation within floral organs.
Pathogen prevalence and abundance in honey bee colonies involved in almond pollination (2015)

Abstract Honey bees are important pollinators of agricultural crops. Since 2006, US beekeepers have experienced high annual honey bee colony losses, which may be attributed to multiple abiotic and biotic factors, including pathogens. However, the relative importance of these factors has not been fully elucidated. To identify the most prevalent pathogens and investigate the relationship between colony strength and health, we assessed pathogen occurrence, prevalence, and abundance in Western US honey bee colonies involved in almond pollination. The most prevalent pathogens were Black queen cell virus (BQCV), Lake Sinai virus 2 (LSV2), Sacbrood virus (SBV), Nosema ceranae , and trypanosomatids. Our results indicated that pathogen prevalence and abundance were associated with both sampling date and beekeeping operation, that prevalence was highest in honey bee samples obtained immediately after almond pollination, and that weak colonies had a greater mean pathogen prevalence than strong colonies.
Synthesis and Thermolysis of Heterocyclic 3-Aza-3-ene-1,5-diynes<sup>1</sup> (2002)

[reaction: see text] Simple, acyclic 3-aza-3-ene-1,5-diynes undergo an aza-Bergman rearrangement to a fleeting 2,5-didehydropyridine (2,5-ddp) intermediate that rapidly ring-opens to beta-alkynylacrylonitrile products. In an effort to access longer-lived 2,5-ddp intermediates, we have prepared heterocyclic 3-aza-3-ene-1,5-diynes. The thermolysis of one such heterocyclic aza-enediyne does not afford products derived from trapping a 2,5-ddp intermediate but rather cyclopropanes that appear to arise from a carbene intermediate and a product that appears to be a trapping product from a 2,3-ddp intermediate.
In-laboratory stopped-flow extended x-ray absorption fine structure apparatus in the dispersive mode for determination of the structure of short-lived intermediates (1994)

We have constructed an in-laboratory stopped-flow extended x-ray absorption fine structure (EXAFS) apparatus by combining laboratory EXAFS equipment in the dispersive mode and a stopped-flow unit with two 150-μm-thick boron nitride windows. The rotating anode x-ray generator with a Mo target was used as an x-ray source. The self-scanning photodiode array was adopted as a position sensitive-linear x-ray detector. In order to obtain a suitable x-ray flux intensity, the accumulation of weak intensities during a short gate time was carried out by repeating the measurements. We have confirmed the performance of our apparatus by repeatedly measuring a number of static EXAFS spectra of 0.20 mol dm−3 aqueous solution of copper(II) sulfate. By use of our newly developed apparatus, we have succeeded in the direct determination of the structure of the reaction intermediate, the heterodinuclear copper(II)/mercury(II) complex, formed in the copper(II) ion incorporation into the homodinuclear mercury(II) complex of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphine.
Diseases of domestic rabbits: a bibliography (1971)

Textbooks dealing with laboratory animal diseases and management are lacking in specific descriptions of the diseases of the rabbit, Oryctolagus cuniculus. In 1956, a bibliography of the rabbit was published (Makepeace, 1956). This bibliography, while including references to studies of rabbit diseases, included references to many other studies covering areas of physiology, nutrition, and management. Further, the 1956 bibliography made no distinction between domestic and wild rabbits. While monitoring the health of rabbits in the facilities at the University of Tennessee Memorial Research Center, we have become acutely aware of the exhaustive literature search required to gain rather general information concerning the aetiology, history, and nature of rabbit diseases. The disease problems encountered in our facility have included congenital defects, metabolic disorders, various infectious diseases, and parasitism. After studying many reports, we concluded t~at the diseases appearing in our facilities, which are fully accredited by t,he American Association for Accreditation of Laboratory Animal Care, probably occur wherever rabbits are housed. Other less obvious diseases are also probably widespread in rabbit colonies. Many of these diseases are poorly understood and have been studied only in a superficial manner. In reviewing the literature relative to these diseases, and later during a systematic examination of Biological Abstracts (1958-69), a comprehensive list of reports dealing with diseases of rabbits was compiled. 'Rabbit' was used as a key word, and the titles and abstracts were then studied to ascertain if the diseases reported and studied occurred naturally in domestic rabbits. This bibliography presents a comprehensive survey of studies of naturallyoccurring rabbit diseases. We believe this bibliography will be a valuable
OFC Tutorial: III-V and Silicon Photonic Integrated Circuit Technologies (2012)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. L. Koch, "OFC Tutorial: III-V and Silicon Photonic Integrated Circuit Technologies," in Optical Fiber Communication Conference, OSA Technical Digest (Optica Publishing Group, 2012), paper OTh4D.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Optimal latch mapping and retiming within a tree (1994)

We propose a technology mapping algorithm that takes existing structural technology-mapping algorithms based on dynamic programming and extends them to retime pipelined circuits. If the circuit to be mapped has a tree structure, our algorithm generates an optimal solution compatible with that structure. The algorithm takes into account gate delays and capacitive loads as latches are moved across the logic. It also supports latches with embedded logic: i.e., cells that combine a D latch with a combinational gate at little extra cost in latch delay.
Convergence Analysis of Pseudo-Transient Continuation (1998)

Pseudo-transient continuation ($\Psi$tc) is a well-known and physically motivated technique for computation of steady state solutions of time-dependent partial differential equations. Standard globalization strategies such as line search or trust region methods often stagnate at local minima. \ptc succeeds in many of these cases by taking advantage of the underlying PDE structure of the problem. Though widely employed, the convergence of \ptc is rarely discussed. In this paper we prove convergence for a generic form of \ptc and illustrate it with two practical strategies.
Unusual Birds and Extensions of Ranges in Sonora, Sinaloa and Chihuahua, Mexico (1938)

Unusual Birds and Extensions of Ranges in Sonora, Sinaloa and Chihuahua, Mexico Get access Robert T. Moore Robert T. Moore California Institute of Technology, Pasadena, California Search for other works by this author on: Oxford Academic Google Scholar The Condor, Volume 40, Issue 1, 1 January 1938, Pages 23–28, https://doi.org/10.2307/1363835 Published: 01 January 1938
DESIGN OF A BEAM FORMING DIELECTRIC CYLINDRICAL EBG ANTENNA (2009)

A novel dielectric cylindrical electronic bandgap antenna is presented and analysed using an in-house developed Finite-Difierence- Time-Domain software simulator. The design steps and the simulations results of a geometrical parametric study are also presented and discussed, focusing on the design of antennas to operate in the X-band with high directivity patterns on the H-plane. Finally, the measurements results of a set of experiments carried out on a prototype showed very good agreement with simulations: 11% fractional bandwidth at 10GHz and an average gain of 9.5dBi are achieved in the impedance bandwidth with 13dB front-to-back-ratio in the azimuthal plane.
An Ising-like model to predict dielectric properties of the relaxor ferroelectric solid solution BaTiO3 - Bi(Zn1/2Ti1/2)O3 (2011)

We model the dielectric properties of the relaxor ferroelectric perovskite solid solution BaTiO$_3$ - Bi(Zn$_{1/2}$Ti$_{1/2}$)O$_3$ (BT-BZT) using ab initio methods combined with an Ising-like model. BT-BZT has both A-site and B-site disorder, which makes it a challenging material to model. The polarization of all possible 2x2x2 supercells of BT-BZT are determined using ab initio methods. The cells are then arranged on a lattice in an Ising-like model to determine long-range dielectric properties. This enables us to predict the long-range disorder effects of relaxors, while keeping the accuracy of ab initio methods. This new model enables us to work with orders of magnitude more atoms than other models such as molecular dynamics. We analyze the Monte Carlo data for a single lattice configuration using the multiple histogram method, and develop a new modified histogram technique to combine data from multiple lattice configurations. Experiments qualitatively agree with our models predicted values of dielectric constant and polarization.
Surface-Active Biomaterials (1984)

Since the discovery in 1969 of a man-made surface-active material that would bond to bone, a range of materials with the same ability has been developed. These include glass, glass-ceramic, and ceramic materials which have a range of reaction rates and from which it should be possible to select a surface-active material for a specific application. The available materials and their similarities, differences, and current clinical applications are reviewed.
Silver Ion Selective Fluoroionophores Based on Anthracene-Linked Polythiazaalkane or Polythiaalkane Derivatives (1999)

A dozen novel fluoroionophores have been synthesized which are polythiazaalkane and polythiaalkane derivatives coupled with an anthracene moiety by methyl, carbonyl, or methylphenylene bridging groups. The protonation and metal ion complexation behavior of analogues were examined in 1,4-dioxane-water solutions spectrophotometrically and spectrophotofluorometrically. The fluoroionophores, 1, 2, 5, and 6 contain basic nitrogen atoms and quench the fluorescence in the free forms because of photoinduced electron transfer (PET) from a nitrogen atom to a photoexcited anthracene unit. The fluorescence was recovered by the protonation on the nitrogen atom. The fluorescence intensities of the other fluoroionophores used here were not dependent on the pH of the solution. On the complexation of the protonated fluoroionophores 1, 2, 5, and 6 with metal ions under the acidic condition, the fluorescence intensities were decreased by the addition of silver ion selectively. Under the same conditions, the other fluoroionophores exhibited a decrease of the fluorescence intensity with the addition of silver ion selectively. These results imply that the fluoroionophores could form complexes and release a proton from the nitrogen atom of the protonated fluoroionophores. The quenching of the fluorescence of the complexed fluoroionophores 3, 4, 7, and 8-12 could be caused by the interaction of a silver ion with a pi-electron of the anthracene unit. The degree of spectral change on the complexation with silver ion is primarily dependent on the strength of the interaction of the bound silver ion with nitrogen atom, for 1, 2, 5, and 6, or with a pi-electron of the anthracene unit, for 3, 4, 7, and 8-12.
Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor (2001)

Death receptors can trigger cell demise dependent or independent of caspases. In WEHI-S fibrosarcoma cells, tumor necrosis factor (TNF) induced an increase in cytosolic cathepsin B activity followed by death with apoptotic features. Surprisingly, this process was enhanced by low, but effectively inhibiting, concentrations of pan-caspase inhibitors. Contrary to caspase inhibitors, a panel of pharmacological cathepsin B inhibitors, the endogenous cathepsin inhibitor cystatin A as well as antisense-mediated depletion of cathepsin B rescued WEHI-S cells from apoptosis triggered by TNF or TNF-related apoptosis-inducing ligand. Thus, cathepsin B can take over the role of the dominant execution protease in death receptor-induced apoptosis. The conservation of this alternative execution pathway was further examined in other tumor cell lines. Here, cathepsin B acted as an essential downstream mediator of TNF-triggered and caspase-initiated apoptosis cascade, whereas apoptosis of primary cells was only minimally dependent on cathepsin B. These data imply that cathepsin B, which is commonly overexpressed in human primary tumors, may have two opposing roles in malignancy, reducing it by its proapoptotic features and enhancing it by its known facilitation of invasion.