gebhart/patrepeval huggingface dataset:
Identification of a G protein alpha subunit from Neurospora crassa that is a member of the Gi family (1993)

Heterotrimeric G proteins, consisting of alpha, beta, and gamma subunits, are implicated in major signal transduction pathways controlling a diversity of functions in eukaryotic organisms. In the filamentous fungus Neurospora crassa, G proteins are implicated in the regulation of several environmental responses. As a first step in studying the role of G proteins in these processes, we have cloned the genes for two alpha subunits, gna-1 and gna-2, from Neurospora. The genes are located on different chromosomes and are differentially regulated during asexual development. The encoded proteins (Gna-1 and Gna-2) are the same size as members of the Gi-alpha family (approximately 40 kDa). The Gna-1 protein sequence is 55% identical overall to members of the Gi family and contains the consensus sequences for ADP-ribosylation by pertussis toxin and incorporation of myristic acid, which are found in this group. These properties make Gna-1 the first identified microbial alpha subunit to be a member of any class. Furthermore, incubation of a N. crassa plasma membrane fraction with pertussis toxin results in ADP-ribosylation of a protein substrate which is the approximate size of Gna-1. The predicted Gna-2 protein sequence does not share a high degree of sequence identity with the Gi class. However, the coding region contains at least one intron in a position conserved in the Gi family. We propose that the Gi family of alpha subunits is ancient and during evolution may have first appeared in filamentous fungi.
Automatic program generation for processing a high level relational-like query language (1979)

The Genealogical Information System (GENISYS) utilizes automatic program generation to produce query specific access paths and query specific data access programs. The query language of GENISYS along with the ability to include user defined algorithms in the data access programs provide the query facilities of a general data base system, while the use of program generation allows efficient data access.
Reliable wireless networks for industrial systems (2003)

This article deals with the application of wireless networks in industries. It discuss about the reliability, adaptability and scalability of wireless networks in industrial environments. It says about wireless formats such as point-to-point links, point-to-multipoint links and about wireless mesh networks. It says about the wireless mesh network's industrial application in distributed control and diagnostic monitoring. And a case study of wireless mesh network in water treatment plant is done. (19 pages)
Two Distinct Pathways Supply Anthranilate as a Precursor of the<i>Pseudomonas</i>Quinolone Signal (2007)

Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with cystic fibrosis (CF). This gram-negative bacterium uses multiple cell-to-cell signals to control numerous cellular functions and virulence. One of these signals is 2-heptyl-3-hydroxy-4-quinolone, which is referred to as the Pseudomonas quinolone signal (PQS). This signal functions as a coinducer for a transcriptional regulator (PqsR) to positively control multiple virulence genes and its own synthesis. PQS production is required for virulence in multiple models of infection, and it has been shown to be produced in the lungs of CF patients infected by P. aeruginosa. One of the precursor compounds from which PQS is synthesized is the metabolite anthranilate. This compound can be derived from the conversion of chorismate to anthranilate by an anthranilate synthase or through the degradation of tryptophan via the anthranilate branch of the kynurenine pathway. In this study, we present data which help to define the kynurenine pathway in P. aeruginosa and show that the kynurenine pathway serves as a critical source of anthranilate for PQS synthesis. We also show that the kyn pathway genes are induced during growth with tryptophan and that they are autoregulated by kynurenine. This study provides solid foundations for the understanding of how P. aeruginosa produces the anthranilate that serves as a precursor to PQS and other 4-quinolones.
A Solid-State Reaction for the Synthesis of CdS Nanowires (2002)

Abstract CdS nanowires have been successfully prepared by solid-state reaction of Cd(Ac)2·2.5H2O and Na2S·9H2O in the presence of PEG 400 at room temperature.
Look-ahead cyclic pitch control using LIDAR (2010)

LIDAR (Light detection and ranging) systems are able to provide preview information of wind disturbances at various distances in front of wind turbines. This information can be used to improve the control of wind turbines. This paper compares a predictive feedforward control structure combined with common PI controllers to a baseline controller and to an H∞ approach showing the advantage of look-ahead control to reduce wind turbine loads. The control design is verified by simulations with a turbulent wind field and a full nonlinear model of the wind turbine.
Preparation and Use of a Boronic Acid Affinity Support for Separation and Quantitation of Glycosylated Hemoglobins (1981)

Abstract Cross-linked agarose activated with carbonyl diimidazole and subsequently coupled to aminophenyl boronic acid provides a highly efficient matrix for separation and quantitation of glycosylated hemoglobins The method described is highly reproducible. rapid and flexible in that it can be adapted to column or batch formats The method can tolerate moderate fluctuations in temperature and pH of buffeused without significantly altering results Hemoglobin fractions separated by this affinity support were Subjected to isoelectric focusing which revealed a heterogeneous population of glucose modified proteins.
Distributed Scheduling in Input Queued Switches (2007)

Dealing with RTTs (round trip time) in IQ switches has been recently recognized as a challenging problem, especially if considering distributed (multi-chip) scheduler implementation which are suited to reduce the hardware complexity in very large, high-speed, switches. Traditional iterative three- or two-phase scheduling algorithms are based on a monolithic implementation, thus allowing instantaneous information exchange among input and output selectors to determine a matching. Multi-chip implementation imply that information exchange among inputs and outputs is delayed by an inter-chip latency. This delay requires non-trivial modifications to scheduling algorithms to allow a fully distributed implementation while keeping good performance. We propose a new scheduling algorithm, named SRR (synchronous round robin), which is suited to a fully distributed implementation and provides good performance if compared with more complex, non fully distributed, previously proposed scheduling algorithms.
Long‐term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age‐related macular degeneration (2009)

Autologous RPE-choroid graft can maintain VA, stable fixation and retinal sensitivity in some patients for over 3 years. The spatial correlation between graft autofluorescence, outer retinal structures on optical coherence tomography and retinal sensitivity are consistent with photoreceptor cell rescue. However, we caution the use of this technique as there is high complication rate and delayed loss of retinal function.
Transmission of beet mosaic virus by the green peach aphid starved before infection feeding under different conditions of air humidity (1959)

Aphids (Myzodes persicae Sulz.) were subjected to infection feeding after starvation for two hours, in varying air humidities. Infection feeding lasted for five minutes. The aphids which were starved under conditions of 0%, 34% and 56% air humidities transmitted the virus to a greater extent than those kept at humidities of 80% and 100%. (At the relative humidity of 0% there was a slight decrease of infectivity, probably due to reduced activity of the aphids). The phenomenon may be explained by the fact than when denied food in a dry atmosphere the aphids lose more water than in a humid atmosphere and hence their rate of feeding when on the source of infection is more rapid, which tends to increase the number of infected individuals. This finding is regarded as having a practical significance.
Long-Term Improvement of Glycemic Control by Insulin Treatment in NIDDM Patients With Secondary Failure (1994)

Improvements of glycemic control and lipoprotein concentrations in patients with NIDDM and secondary failure persist also after insulin treatment for 2-3 years in spite of weight gain and hyperinsulinemia.
(Pro)renin Receptor in Kidney Development and Disease (2011)

The renin-angiotensin system (RAS), a key regulator of the blood pressure and fluid/electrolyte homeostasis, also plays a critical role in kidney development. All the components of the RAS are expressed in the developing metanephros. Moreover, mutations in the genes encoding components of the RAS in mice or humans are associated with a broad spectrum of congenital anomalies of the kidney and urinary tract (CAKUT). These forms of CAKUT include renal papillary hypoplasia, hydronephrosis, duplicated collecting system, renal tubular dysgenesis, renal vascular abnormalities, and aberrant glomerulogenesis. Emerging evidence indicates that (pro)renin receptor (PRR), a novel component of the RAS, is essential for proper kidney development and that aberrant PRR signaling is causally linked to cardiovascular and renal disease. This paper describes the role of the RAS in kidney development and highlights emerging insights into the cellular and molecular mechanisms by which the PRR may regulate this critical morphogenetic process.
Artesunate Demonstrates <i>in vitro</i> Synergism with Several Antiviral Agents against Human Cytomegalovirus (2015)

These results suggest that the combination of ART with the antiviral agents tested in this study could be an interesting strategy for the treatment of HCMV infections to reduce toxicity and drug-resistance development.
Research for Practice: Cryptocurrencies, Blockchains, and Smart Contracts; Hardware for Deep Learning (2016)

First, Arvind Narayanan and Andrew Miller, co-authors of the increasingly popular open-access Princeton Bitcoin textbook, provide an overview of ongoing research in cryptocurrencies. Second, Song Han provides an overview of hardware trends related to another long-studied academic problem that has recently seen an explosion in popularity: deep learning.
Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate (2016)

In this study the detailed characteristic of the anti-cancer agent 3-bromopyruvate (3-BP) activity in the yeast Saccharomyces cerevisiae model is described, with the emphasis on its influence on energetic metabolism of the cell. It shows that 3-BP toxicity in yeast is strain-dependent and influenced by the glucose-repression system. Its toxic effect is mainly due to the rapid depletion of intracellular ATP. Moreover, lack of the Whi2p phosphatase results in strongly increased sensitivity of yeast cells to 3-BP, possibly due to the non-functional system of mitophagy of damaged mitochondria through the Ras-cAMP-PKA pathway. Single deletions of genes encoding glycolytic enzymes, the TCA cycle enzymes and mitochondrial carriers result in multiple effects after 3-BP treatment. However, it can be concluded that activity of the pentose phosphate pathway is necessary to prevent the toxicity of 3-BP, probably due to the fact that large amounts of NADPH are produced by this pathway, ensuring the reducing force needed for glutathione reduction, crucial to cope with the oxidative stress. Moreover, single deletions of genes encoding the TCA cycle enzymes and mitochondrial carriers generally cause sensitivity to 3-BP, while totally inactive mitochondrial respiration in the rho0 mutant resulted in increased resistance to 3-BP.
GATA-4 and Serum Response Factor Regulate Transcription of the Muscle-specific Carnitine Palmitoyltransferase I β in Rat Heart (2001)

Transcriptional regulation of nuclear encoded mitochondrial proteins is dependent on nuclear transcription factors that act on genes encoding key components of mitochondrial transcription, replication, and heme biosynthetic machinery. Cellular factors that target expression of proteins to the heart have been well characterized with respect to excitation-contraction coupling. No information currently exists that examines whether parallel transcriptional mechanisms regulate nuclear encoded expression of heart-specific mitochondrial isoforms. The muscle CPT-Ibeta isoform in heart is a TATA-less gene that uses Sp-1 proteins to support basal expression. The rat cardiac fatty acid response element (-301/-289), previously characterized in the human gene, is responsive to oleic acid following serum deprivation. Deletion and mutational analysis of the 5'-flanking sequence of the carnitine palmitoyltransferase Ibeta (CPT-Ibeta) gene defines regulatory regions in the -391/+80 promoter luciferase construct. When deleted or mutated constructs were individually transfected into cardiac myocytes, CPT-I/luciferase reporter gene expression was significantly depressed at sites involving a putative MEF2 sequence downstream from the fatty acid response element and a cluster of heart-specific regulatory regions flanked by two Sp1 elements. Each site demonstrated binding to cardiac nuclear proteins and competition specificity (or supershifts) with oligonucleotides and antibodies. Individual expression vectors for Nkx2.5, serum response factor (SRF), and GATA4 enhanced CPT-I reporter gene expression 4-36-fold in CV-1 cells. Although cotransfection of Nkx and SRF produced additive luciferase expression, the combination of SRF and GATA-4 cotransfection resulted in synergistic activation of CPT-Ibeta. The results demonstrate that SRF and the tissue-restricted isoform, GATA-4, drive robust gene transcription of a mitochondrial protein highly expressed in heart.
Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor‐κB activation in J774 macrophages (1998)

We investigated the effect of PGE2 and iloprost (a prostacyclin analogue) on inducible nitric oxide synthase (iNOS) protein expression and nuclear factor-kappaB (NF-kappaB) activation in lipopolysaccharide (LPS)-stimulated J774 macrophages. Incubation of J774 cells with LPS (10 microg/ml) caused an increase of iNOS protein expression which was prevented in a concentration-dependent fashion by PGE2 (0.1, 1, 10 microM) and iloprost (0.01, 0.1, 1 microM). Electrophoretic mobility shift assay indicated that both prostanoids blocked the activation of NF-kappaB, a transcription factor necessary for NO synthase induction. PGE2 and iloprost also blocked disappearance of I kappaB-alpha from cytosolic fraction and nuclear translocation of NF-kappaB subunits p50 and p65. These results show for the first time that PGE2 and iloprost down-regulate iNOS protein expression by inhibiting NF-kappaB activation and suggest a negative feed-back mechanism that may be important for limiting excessive or prolonged NO production in pathological events.
Radicaux libres dérivés de sucres. V. Dérivés d'osamines N‐hydroxylées et composés voisins Communication préliminaire (1982)

Free sugar radicals. V. Deoxyhydroxylaminosugar derivatives and related compounds We describe several synthetic routes to deoxyhydroxylaminosugar derivatives of the type Glyc‐N(OH)‐R where Glyc stands for a sugar moiety linked by any of its C‐atoms except the anomeric one and R for one of the following substituants: H‐atom, acyl, phosphoryl groups, aminoacid or sugar residues. Compounds of the above structure are potentially close analogs, homoisosteres, NOH replacing O, of biochemically important molecules. Under aerobic conditions, solutions of these derivatives contain minute concentrations of the corresponding nitroxide radicals which do not decrease significantly the resolution of the NMR. spectra but render these compounds usable as a new kind of spin labels. Spectroscopic properties ( 1 H‐NMR., 13 C‐NMR., ESR.) of some of these compounds are reported.
Distribution of Open Reading Frames of Plasticity Region of Strain J99 in <i>Helicobacter pylori</i> Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica (2000)

The plasticity region of Helicobacter pylori strain J99 is a large chromosomal segment containing 33 strain-specific open reading frames (ORFs) with characteristics of a pathogenicity island. To study the diversity of the plasticity region, 22 probes corresponding to 20 ORFs inside the plasticity region and two ORFs on its boundaries were hybridized to genomic DNA isolated from clinical strains of H. pylori from patients with gastritis or gastric adenocarcinoma. Highly variable hybridization patterns were observed. The majority of the clinical strains presented a hybridization profile similar to that of J99; thus, these ORFs are not J99 strain specific. No association was found between a particular hybridization pattern and the clinical origin of the strain. Nevertheless, two single ORFs (JHP940 and JHP947) were more likely to be found in gastric cancer strains. They may be new pathogenicity markers. An in vitro expression study of these ORFs was also performed for the J99 strain, under different conditions. Thirteen ORFs were consistently expressed, six were consistently shut off, and three were expressed differentially. Most of the constitutionally expressed genes were located on the 3' part of the plasticity region. Our results show that the plasticity region, rather than being considered a pathogenicity island per se, should be considered a genomic island, which represents a large fragment of foreign DNA integrated into the genome and not necessarily implicated in the pathogenic capacity of the strain.
In-framework ion dipole polarizabilities in non-porous and porous silicates and aluminosilicates, determined from Auger electron spectroscopy data (1993)

The in-framework ion dipole polarizability is determined by evaluating the absolute extra-atomic relaxation energy during the two-electron Auger process. A simple model has been derived by combining general relaxation theory with an electrostatic model due to Moretti (Surf. Interface Anal., 1990, 16, 159). The method is applied to crystalline MgO in order to check its validity. The result is in very good agreement with (ab initio) theoretical and experimental data. When applied to porous and non-porous silicates and aluminosilicates, the method is able to distinguish between different types of in-framework oxygens according to their site symmetry and the nature of the cation (Si, Al).
Thromboelastography (2001)

The Thromboelastograph has now been in use for over 50 years and has been largely regarded as a research tool. Increasing automation and refinement of the TEG and standardisation of results has led to decreased speculation regarding its validity as an assay of haemostasis. There are increasing clinical applications including cardiothoracic surgery and liver transplantation. This review discusses the principles and limitations of the TEG. It also focuses on the current clinical applications and potential research interests.
Microelectromechanical systems in electrical metrology (2001)

Microelectromechanical systems (MEMS) will have an important role in metrology. The essential features of a MEMS are (1) a piece of single crystal silicon forming a spring; (2) metallized surfaces of silicon structures that define an electrode geometry; (3) electrostatic forces between surfaces in a vacuum. With an electrostatic drive and readout such a system will dissipate very little power. In addition, compared to semiconducting devices, microelectromechanical components are large in size, and hence a low 1/f noise level is expected. We show that a MEMS can be used, in principle, to realize both a DC and an AC voltage reference, an AC/DC converter, a DC current reference, a low frequency voltage divider, a microwave and millimeter wave detector, etc. Unfortunately, existing MEMS technologies, where uncoated silicon structures form the electrodes, cannot be used due to trapped charges in silicon dioxide or on its surface. Thus, metallization of the surface is needed. We report preliminary results of our DC voltage reference showing a relative fluctuation level below 1 /spl mu/V/V.
Effects of hydrocolloids on processing and qualities of wheat tortillas (1993)

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A Novel 3D Cell Array Architecture for Terra-Bit NAND Flash Memory (2011)

A novel 3D flash cell array architecture, called "hybrid 3D", is proposed to provide the distinctive low address selection method of stacked channels, suitable for conventional NAND page operation. The strings are composed of GAA type selector and double gate type cells, and their key characters were verified independently. The GAA selectors showed excellent and uniform switching character, and double gate MANOS cells were expected to provide enough program window and acceptable reliability for MLC. Extendibility of hybrid 3D was rigorously estimated within the acceptable range of channel stacking and word line scaling, where 2 Tb NAND flash memory would be available just by 16 channel stacks.
한국성인의 식사패턴과 본인이 인지한 양대구강병과의 관련성 연구 (2010)

Objectives: Targeting Korean adults, the food pattern are grasped. And, its correlation with oral disease is analyzed. In order to offer basic data to developing the nutritional policy and nutritional program for the future prevention from oral disease, a research was conducted by utilizing the Korean National Health and Nutrition Examination Survey 2005(the 3rd term). Methods: The subjects in this study were 6,526 adults in more than fully 19 years among 9,047 persons who participated in the food intake survey out of those who completed the health interview survey. The statistical analysis was analyzed by using SPSS 12.0 program. Results: 1) As a result of Group Analyzing was indicated to dangerous-type food pattern and protection-type food pattern. 2) As a result of analyzing the answers for having dental caries in the annually personal recognition was indicated to be high in the dangerous-type food pattern, and had not the statistically significant difference. 3) As a result of analyzing the answers for having periodontal disease in the annually personal recognition was indicated to be high in the dangerous-type food pattern, and had the statistically significant difference(p<0.05). 4) As a result of analyzing the food pattern factors that have influence upon both major oral illnesses in the annually personal recognition, the person, who has the dangerous-type food pattern, had high risk level of the periodontal disease in the annually personal recognition. Conclusions: In the above results, as a result of surveying and analyzing importance of the food pattern in the incidence of both major oral illnesses, it is considered that there will be necessity of continuing to research into developing the nutritional policy and nutritional program in order to prevent oral illness in the future.
Baseline corrector for boxcar integrator instruments and its application to plasma chromatography (1977)

A circuit is described for correcting the baseline drift of boxcar integrator instruments, specifically a plasma chromatograph. The circuit is divided into three parts: timing, modulation, an demodulation. The timing circuit derives a trigger pulse and a low-frequency modulation pulse from the power line frequency. The modulation circuit imposes external gate-time determination on the internal timing of the plasma chromatograph. The demodulation circuit uses voltage-to-frequency conversion and multichannel scaling. The technique is general and useful for other drifting baseline situations.