gebhart/patrepeval huggingface dataset:
Ceramic Shrinks When the Heat Goes On (1996)

It's hard to break the laws of physics, but sometimes one can bend the rules. Take the well-founded principle that more heat means more size: Added energy—heat—usually causes atoms to swing around more violently, taking up more space and causing materials to expand. But on page 90 of this issue, a group of researchers describe a ceramic that's found a huge loophole in the rule: It steadily shrinks as the temperature rises over 1000 degrees. The slimming secret, the scientists say, is in the material's zirconium-tungsten-oxygen lattice.
Current trends in the prevalence of Cryptococcus gattii in the United States and Canada (2015)

The incidence of Cryptococcus gattii infections in both Canada and the United States (US) is provided in this literature review beyond the British Columbia (BC) outbreak (1999-2013). Based on a search of the literature, case reports of C. gattii human infections including the prevalent molecular genotypes causing these infections in both Canada and the US have been documented since the C. gattii outbreak in BC. The literature reveals that: i) although C. gattii infections continue to be reported in both countries, the preliminary overall number of confirmed C. gattii infections may be decreasing in both Canada and the US (~23 cases each in 2012 versus ~17 and 20 cases, respectively in 2013); ii) C. gattii genotype distribution is region-dependent; iii) C. gattii is more frequently isolated from infections in the immunocompromised host (including acquired immune deficiency syndrome [AIDS] infection) than previously expected; iv) although pulmonary disease is higher than in C. neoformans infections, central nervous system disease is also reported among patients infected with C. gattii.
Molecular analysis of HLA-DR polymorphism in polymyalgia rheumatica. Swiss Group for Research on HLA in Polymyalgia Rheumatica. (1997)

PMR may be associated with the HLA-DR beta 1 70-74 shared epitope. This association, however, would be much weaker for PMR than for RA, particularly with the shared epitope at double dose. PMR is clearly not associated with the HLA-DR beta 1 DRYF 28-31 motif.
Material Design for Piezochromic Luminescence:  Hydrogen-Bond-Directed Assemblies of a Pyrene Derivative (2007)

A novel design principle for materials showing piezochromic luminescence is proposed. Amide-substituted tetraphenylpyrene C6TPPy, composed of a planar fluorescent core and multiple hydrogen-binding sites, displays a remarkable change and restoration of its luminescence color by pressing with a spatula and heating, respectively.
Use of Subliminal Stimulation to Enhance Learning Mathematics (1992)

24 students, who participated in a summer session mathematics enrichment program, viewed subliminally presented messages. Prior to each class, the experimental group of 16 viewed a subliminally presented psychoanalytic merging message and the control group of 8 viewed a neutral message. After 20 sessions students were retested. Experimental students had higher mathematics scores than controls. These data are compared with results obtained by other investigators.
Usporedba uspjeha inicijalne terapije oboljelih od agresivnog i kroničnoga parodontitisa (2005)

Usporedba uspjeha inicijalne terapije oboljelih od agresivnog i kroninoga parodontitisa
NPSNET: aural cues for virtual world immersion (1992)

NPSNET is a low-cost visual and aural simulation system designed and implemented at the Naval Postgraduate School. NPSNET is an example of a virtual world simulation environment that incorporates real-time aural cues through software-hardware interaction. In the current implementation of NPSNET, a graphics workstation functions in the sound server role which involves sending and receiving networked sound message packets across a Local Area Network, composed of multiple graphics workstations. The network messages contain sound file identification information that is transmitted from the sound server across an RS-422 protocol communication line to a serial to Musical Instrument Digital Interface (MIDI) converter. The MIDI converter, in turn relays the sound byte to a sampler, an electronic recording and playback device. The sampler correlates the hexadecimal input to a specific note or stored sound and sends it as an audio signal to speakers via an amplifier. The realism of a simulation is improved by involving multiple participant senses and removing external distractions. This thesis describes the incorporation of sound as aural cues, and the enhancement they provide in the virtual simulation environment of NPSNET.
Neurocysticercosis presenting as stroke. (2000)

Stroke is a common but under recognized complication of neurocysticercosis (NCC). We report six patients having NCC who presented with stroke. All patients were young with no vascular risk factors. The arteritis which resulted in ischaemic infarct in these patients was related to the presence and severity of arachnoiditis. All patients responded well to steroids and albendazole therapy with minimal residual deficit.
Media Containing Liquefied Nutrients for Mass-Rearing Larvae of the Screw-Worm1 (1971)

Journal Article Media Containing Liquefied Nutrients for Mass-Rearing Larvae of the Screw-Worm Get access Richard E. Gingrich, Richard E. Gingrich Agricultural Research Service, USDA Search for other works by this author on: Oxford Academic PubMed Google Scholar A. J. Graham, A. J. Graham Agricultural Research Service, USDA Search for other works by this author on: Oxford Academic PubMed Google Scholar B. G. Hightower B. G. Hightower Agricultural Research Service, USDA Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 64, Issue 3, 15 June 1971, Pages 678–683, https://doi.org/10.1093/jee/64.3.678 Published: 15 June 1971 Article history Received: 28 July 1970 Published: 15 June 1971
Inherited predisposition to myeloproliferative neoplasms (2013)

Myeloproliferative neoplasms (MPNs) are haematological disorders characterized by an overproduction of mature myeloid cells with a tendency to transform to acute myeloid leukaemia. Clonal proliferation of myeloid progenitor cells is driven by somatically acquired mutations, most notably JAK2 V617F, but there are important features relating to pathogenesis and phenotypic diversity that cannot be explained by acquired mutations alone. In this review we consider what is currently known about the role that inherited factors play in the development and biology of both sporadic and familial forms of MPN. Although most MPN cases appear to be sporadic, familial predisposition has been recognized for many years in a subset of cases and epidemiological studies have indicated the presence of common susceptibility alleles. Currently the JAK2 46/1 haplotype (also referred to as 'GGCC') is the strongest known predisposition factor for sporadic MPNs carrying a JAK2 V617F mutation, explaining a large proportion of the heritability of this disorder. Less is known about what genetic variants predispose to MPNs that lack JAK2 V617F, but there have been recent reports of interesting associations in biologically plausible candidates, and more loci are set to emerge with the application of systematic genome-wide association methodologies. Several highly penetrant predisposition variants that affect erythropoietin signalling, thrombopoietin signalling or oxygen sensing have been characterized in families with nonclonal hereditary erythrocytosis or thrombocytosis, but much less is known about familial predisposition to true clonal MPN. The heterogeneous pattern of inheritance and presumed genetic heterogeneity in these families makes analysis difficult, but whole exome or genome sequencing should provide novel insights into these elusive disorders.
Preservation of RNA for in situ hybridization: Carnoy's versus formaldehyde fixation. (1992)

Tissues fixed with organic solvent fixatives such as Carnoy's solution are known to give poor and erratic results with in situ hybridization, whereas those fixed with paraformaldehyde produce more consistent results. To understand this difference and to improve the utility of Carnoy's-fixed tissue for in situ hybridization, we explored several parameters of RNA integrity and preservation. Carnoy's-fixed, paraffin-embedded livers and paraformaldehyde-fixed, paraffin-embedded livers of mice were compared for RNA extractability, degradation, and hybridizability. In addition, retention of RNA in tissue sections after sequential in situ hybridization treatments was compared. RNA was found to be easily extractable from Carnoy's-fixed liver and was well preserved, with only slight degradation of high molecular weight RNA. Conversely, only a small percentage of the RNA was extractable from paraformaldehyde-fixed liver unless the tissue was digested with protease. The extracted RNA was well preserved, without detectable degradation. Sections of tissue fixed in Carnoy's solution subjected to in situ hybridization retained only about 10% of their original RNA content and gave correspondingly weak in situ hybridization signals. Formaldehyde-fixed tissues retained much more of the RNA (about 45%) and produced strong in situ hybridization signals. Treatment of Carnoy's-fixed tissue sections with vaporous formaldehyde increased retention of RNA and provided in situ hybridization signals comparable with those of paraformaldehyde-fixed tissues.
CN Coupling of Indoles and Carbazoles with Aromatic Chlorides Catalyzed by a Single‐Component NHC‐Nickel(0) Precursor (2015)

Abstract A new and efficient nickel‐based protocol for the N ‐arylation of indoles and carbazoles with aromatic chlorides, the least expensive of the aryl halides, is described. The procedure provides selectively N ‐(hetero)arylation products in good to high yields, in short reaction times and without adding an excess of ligands. magnified image
Target validation for genomics using peptide‐specific phage antibodies: A study of five gene products overexpressed in colorectal cancer (2002)

Genomic approaches are providing a wealth of information on differential gene expression in cancer. To identify the most interesting genes amongst the many identified, high-throughput methods for analysis of genes at the translational level are required. We have used a rapid method for the in vitro selection of antibodies to peptide antigens for the generation of probes to 5 gene products that we have found to be overexpressed in colorectal cancer. The rationale of our study was to select a non-immune phage displayed human antibody library on peptides designed from the coding regions of the gene sequences and to verify whether such antibodies would be suitable probes for the parental protein in immunohistochemical and Western blot analysis. After the generation of a profile of genes overexpressed in primary colorectal cancer (CRC) we selected 5 genes, Ese-3b, Fls353, PBEF, SPARC and Smad5 for a more detailed analysis using phage display-derived antibodies. For these 5 antigens we designed 14-20 amino acid peptides predicted to be exposed on the surface of the parental protein. Selection of a large phage displayed antibody library resulted in specific antibodies for 6 of 8 different peptides with between 2 and 15 different antibodies isolated per peptide. Of 20 antibodies tested, 2 antibodies recognized the putative parental protein from primary CRC tissue. An antibody specific for a PBEF-derived peptide (Fab/PBEF-D4) was shown to recognize a protein product of the expected molecular weight in Western blotting and showed overexpression in n = 6/8 matched tumor/normal protein lysates. Furthermore, in immunohistochemistry this antibody showed restricted staining of the tumor stromal compartment with no detectable staining of epithelial cells. The discovery that PBEF is overexpressed in cancer is unexpected given that the normal function of PBEF is as a cytokine required for the maturation of B cell precursors. We also report on the isolation of an antibody (Fab/SMAD-50) specific for a Smad5-derived peptide that showed cytoplasmic staining of epithelial cells in both CRC tumor and matched normal mucosa. Fab/SMAD-50 also bound to a group of proteins in Western blotting with molecular weights consistent with belonging to the Smad family. These antibodies may be suitable probes for further investigation of the roles of PBEF and Smad5 in cancer. The amenability of phage display to automation suggests that this approach may be developed for implementation on a genomics scale. Indeed, the large-scale generation of antibody probes that can be used to study protein expression in situ would be of great value in target validation for functional genomics.
Uniaxial Stress Apparatus for Measurements of Optical Activity (1995)

A device is described with which the optical activity of crystalline materials under stress can be measured. The sample is not moved, but a three-axis rotation is possible.
Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of <i>APP</i> , <i>ETS2</i> , and <i>ERG</i> genes (2004)

Molecular mechanisms of leukemogenesis have been successfully unraveled by studying genes involved in simple rearrangements including balanced translocations and inversions. In contrast, little is known about genes altered in complex karyotypic abnormalities. We studied acute myeloid leukemia (AML) patients with complex karyotypes and abnormal chromosome 21. High-resolution bacterial artificial chromosome (BAC) array-based comparative genomic hybridization disclosed amplification predominantly in the 25- to 30-megabase (MB) region that harbors the APP gene (26.3 MB) and at position 38.7-39.1 MB that harbors the transcription factors ERG and ETS2. Using oligonucleotide arrays, APP was by far the most overexpressed gene (mean fold change 19.74, P = 0.0003) compared to a control group of AML with normal cytogenetics; ERG and ETS2 also ranked among the most highly expressed chromosome 21 genes. Overexpression of APP and ETS2 correlated with genomic amplification, but high APP expression occurred even in a subset of AML patients with normal cytogenetics (10 of 64, 16%). APP encodes a glycoprotein of unknown function previously implicated in Alzheimer's disease, but not in AML. We hypothesize that APP and the transcription factors ERG and ETS2 are altered by yet unknown molecular mechanisms involved in leukemogenesis. Our results highlight the value of molecularly dissecting leukemic cells with complex karyotypes.
Modeling and validation of service-oriented architectures (2003)

Most applications developed today rely on a given middleware platform which governs the interaction between components, the access to resources, etc. To decide, which platform is suitable for a given application (or more generally, to understand the interaction between application and platform), we propose UML models of both the architectural style of the platform and the application scenario. Based on a formal interpretation of these as graphs and graph transformation systems, we are able to validate the consistency between platform and application.
Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. (1986)

Hydroxyurea inactivates ribonucleotide reductase from mammalian cells and thereby depletes them of the deoxynucleoside triphosphates required for DNA replication. In cultures of exponentially growing 3T6 cells, with 60-70% of the cells in S-phase, 3 mM hydroxyurea rapidly stopped ribonucleotide reduction and DNA synthesis (incorporation of labeled thymidine). The pool of deoxyadenosine triphosphate (dATP) decreased in size primarily, but also the pools of the triphosphates of deoxyguanosine and deoxycytidine (dCTP) were depleted. Paradoxically, the pool of thymidine triphosphate increased. After addition of hydroxyurea this pool was fed by a net influx and phosphorylation of deoxyuridine from the medium and by deamination of intracellular dCTP. An influx of deoxycytidine from the medium contributed to the maintenance of intracellular dCTP. 10 min after addition of hydroxyurea, DNA synthesis appeared to be completely blocked even though the dATP pool was only moderately decreased. As possible explanations for this discrepancy, we discuss compartmentation of pools and/or vulnerability of newly formed DNA strands to nuclease action and pyrophosphorolysis.
Efficient packet classification for network intrusion detection using FPGA (2005)

Using FPGA technology for real-time network intrusion detection has gained many research efforts recently. In this paper, a novel packet classification architecture called BV-TCAM is presented, which is implemented for an FPGA-based Network Intrusion Detection System (NIDS). The classifier can report multiple matches at gigabit per second network link rates. The BV-TCAM architecture combines the Ternary Content Addressable Memory (TCAM) and the Bit Vector (BV) algorithm to effectively compress the data representations and boost throughput. A tree-bitmap implementation of the BV algorithm is used for source and destination port lookup while a TCAM performs the lookup of the other header fields, which can be represented as a prefix or exact value. The architecture eliminates the requirement for prefix expansion of port ranges. With the aid of a small embedded TCAM, packet classification can be implemented in a relatively small part of the available logic of an FPGA. The design is prototyped and evaluated in a Xilinx FPGA XCV2000E on the FPX platform. Even with the most difficult set of rules and packet inputs, the circuit is fast enough to sustain OC48 traffic throughput. Using larger and faster FPGAs, the system can work at speeds greater than OC192.
Noise characteristics of a 750-MHz electronically tunable resonator for electron paramagnetic resonance spectroscopy (2019)

This paper describes an experimental investigation of the noise characteristics of a 750-MHz electronically tunable resonator for electron paramagnetic resonance (EPR) spectroscopy. The RF noise of the tunable resonator and its influence on the baseline noise of an EPR spectrum were systematically measured, considering both the noise of varactor diodes used in the impedance matching network of the resonator and noise from the ambient environment. The influence of magnetic field modulation and its amplitude on the baseline noise of the EPR spectrum was also measured. The tunable resonator itself increased the noise level of the spectral baseline of a home-built 750-MHz continuous-wave (CW) EPR spectrometer. A significant decrease in the noise level of the EPR spectral baseline was demonstrated by replacing the varactor diodes in the matching network by a trimmer capacitor, which led to a 6.1-fold improvement in EPR spectrum signal-to-noise ratio.
Solubility of hydrofluorocarbon (HFC‐134a, HFC‐152a) and hydrochlorofluorocarbon (HCFC‐142b) blowing agents in polystyrene (2000)

Abstract Solubilities of blowing agents (HFC‐134a, HCFC‐142b, and HFC‐152a) in polystyrene (PS) were measured at temperatures from 348 to 473 K and pressures up to 3.2 MPa with a volumetric method. For all conditions, the solubility of the blowing agents in PS decreased with increasing temperature. At a given temperature and pressure, the solubility of HFC‐134a, HFC‐152a, and HCFC‐142b in PS increased in that order. Solubilities could be correlated with the Sanchez‐Lacombe equation of state with temperature‐dependent binary interaction parameters to within 3.4% average relative percent deviation. The temperature dependence of the Henry's constants, K p , for the blowing agents were found to have a linear relationship between ln(1/ K p ) and ( T c / T ) 2 , where T c is the critical temperature of the blowing agent.
New Insights into Biology, Prognostic Factors, and Current Therapeutic Strategies in Chronic Lymphocytic Leukemia (2013)

Chronic lymphocytic leukemia (CLL) is characterized by the clonal proliferation and accumulation of mature B lymphocytes. CLL cells show an antiapoptotic profile, suggesting the important role of apoptosis inhibition in the disease development. However, there is some population of proliferating CLL cells, which may also play a role in progression of the disease. There are several newer, biological prognostic factors in CLL. Currently, cytogenetic abnormalities with different prognostic values seem to be the most biologically relevant. During the last decades, the treatment of CLL has been significantly changed. Different strategies such as monotherapy with chlorambucil and purine nucleoside analogues (PNA) used alone or in combination with cyclophosphamide have been introduced. Most recently, immunochemotherapy with anti-CD20 monoclonal antibody, rituximab, combined with fludarabine and cyclophosphamide, became a gold standard of first-line treatment in eligible CLL patients. Currently, new treatment strategies including new monoclonal antibodies, bendamustine, lenalidomide, or inhibitors of several cell signaling pathways are under clinical studies in resistant/relapsed CLL patients. Moreover, allogeneic stem cell transplantation has to be considered, especially in younger high risk patients, for example, those who are resistant to PNA or those with 17p deletion. In this paper, we present the most important recent advances in CLL biology and treatment.
Determination of .alpha.- and .beta.-carotene in some raw fruits and vegetables by high-performance liquid chromatography (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of .alpha.- and .beta.-carotene in some raw fruits and vegetables by high-performance liquid chromatographyRodney J. BushwayCite this: J. Agric. Food Chem. 1986, 34, 3, 409–412Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://doi.org/10.1021/jf00069a006RIGHTS & PERMISSIONSArticle Views908Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (522 KB) Get e-Alertsclose Get e-Alerts
Bacteriophage survival: multiple mechanisms for avoiding the deoxyribonucleic acid restriction systems of their hosts (1983)

Les bacteriophages ont appris a vivre avec les enzymes de restriction de leur hote en developpant de nombreux mecanismes differents pour eviter les pires effets des systemes de restriction. Un mecanisme de restriction d'une sorte ou d'une autre a ete trouve dans pratiquement chaque phage examine. Dans cette revue sont decrits les mecanismes utilises pour les bacteriophages de Bacillus subtilis et Escherichia coli