gebhart/patrepeval huggingface dataset:
A 40-Year Journey Through Bioconversion of Lignocellulosic Wastes to Mushrooms and Dietary Supplements (2001)

This presentation covers investigations of early attempts to convert lignocellulosic materials, also identified as cellulosic biomass, containing hemicellulose, cellulose, and lignin, into primary components for producing edible and medicinal mushrooms. These range from the study of life cycles to the application of genetics and breeding, all directed toward the improvement of mushroom strains so as to use the lignocellulosic wastes more effectively. Also traced are attempts in recent decades to develop new disciplines"mushroom biology" replacing "mushroomology," "mushroom products" distinguished from "mushroom production," and "nutriceutical" from "nutraceuticals." Mushroom production evolved from mushroom science and is concerned with mushroom cultivation and production (mushrooms themselves), whereas mushroom products are generated by mushroom biotechnology and are connected with mushroom derivatives (mushroom nutriceuticals/dietary supplements). These are the two legs of the modern mushroom-based industry. The status of the world marketing value of mushrooms and their products is also reviewed, with projection of potential contribution to human welfare in the 21st century: the "nongreen revolution." The "nongreen revolution" has had and will continue to have a positive global impact on long-term food nutrition, health care, environmental conservation and regeneration, and economic and social change. It should be emphasized that good quality and honest products of both mushroom crops and mushroom derivatives are of paramount importance in earning enduring public credibility and securing an expanding market in the world.
Small Untranslated RNA Antitoxin in<i>Bacillus subtilis</i> (2005)

Toxin-antitoxin (TA) modules are pairs of genes in which one member encodes a toxin that is neutralized or whose synthesis is prevented by the action of the product of the second gene, an antitoxin, which is either protein or RNA. We now report the identification of a TA module in the chromosome of Bacillus subtilis in which the antitoxin is an antisense RNA. The antitoxin, which is called RatA (for RNA antitoxin A), is a small (222 nucleotides), untranslated RNA that blocks the accumulation of the mRNA for a toxic peptide TxpA (for toxic peptide A; formerly YqdB). The txpA and ratA genes are in convergent orientation and overlap by ca. 75 nucleotides, such that the 3' region of ratA is complementary to the 3' region of txpA. Deletion of ratA led to increased levels of txpA mRNA and lysis of the cells. Overexpression of txpA also caused cell lysis and death, a phenotype that was prevented by simultaneous overexpression of ratA. We propose that the ratA transcript is an antisense RNA that anneals to the 3' end of the txpA mRNA, thereby triggering its degradation.
Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1 (2016)

An integrated methodology is described to establish ligand requirements for heparan sulfate (HS) binding proteins based on a workflow in which HS octasaccharides are produced by partial enzymatic degradation of natural HS followed by size exclusion purification, affinity enrichment using an immobilized HS-binding protein of interest, putative structure determination of isolated compounds by a hydrophilic interaction chromatography-high-resolution mass spectrometry platform, and chemical synthesis of well-defined HS oligosaccharides for structure-activity relationship studies. The methodology was used to establish the ligand requirements of human Roundabout receptor 1 (Robo1), which is involved in a number of developmental processes. Mass spectrometric analysis of the starting octasaccharide mixture and the Robo1-bound fraction indicated that Robo1 has a preference for a specific set of structures. Further analysis was performed by sequential permethylation, desulfation, and pertrideuteroacetylation followed by online separation and structural analysis by MS/MS. Sequences of tetrasaccharides could be deduced from the data, and by combining the compositional and sequence data, a putative octasaccharide ligand could be proposed (GlA-GlcNS6S-IdoA-GlcNS-IdoA2S-GlcNS6S-IdoA-GlcNAc6S). A modular synthetic approach was employed to prepare the target compound, and binding studies by surface plasmon resonance (SPR) confirmed it to be a high affinity ligand for Robo1. Further studies with a number of tetrasaccharides confirmed that sulfate esters at C-6 are critical for binding, whereas such functionalities at C-2 substantially reduce binding. High affinity ligands were able to reverse a reduction in endothelial cell migration induced by Slit2-Robo1 signaling.
L'utilisation de la construction neuve (1970)

Bodin Jean-Louis. L'utilisation de la construction neuve. In: Economie et statistique, n°8, Janvier 1970. pp. 49-51.
Safety of Epidural Administration of Osteogenic Protein-1 (OP-1/BMP-7) (2007)

OP-1 application in the epidural space is safe based on behavioral measures and macroscopic observation on ectopic bone formation at 21 days after surgery.
Focus Tracking in Time Domain Optical Coherence Tomography using Membrane Mirrors Operated Near Snap-Down (2006)

We describe MEMS membrane mirrors for dynamic focus tracking in time-domain OCT. We demonstrate stable, distortion-compensated nearly sinusoidal motion at 10 kHz at an amplitude of 50% of the air gap
Quantitative assessment of ribosome drop-off in<i>E. coli</i> (2016)

Premature ribosome drop-off is one of the major errors in translation of mRNA by ribosomes. However, repeated analyses of Ribo-seq data failed to quantify its strength inE. coli Relying on a novel highly sensitive data analysis method we show that a significant rate of ribosome drop-off is measurable and can be quantified also when cells are cultured under non-stressing conditions. Moreover, we find that the drop-off rate is highly variable, depending on multiple factors. In particular, under environmental stress such as amino acid starvation or ethanol intoxication, the drop-off rate markedly increases.
Preparation of stable dispersions of layered double hydroxides (LDHs) in nonpolar hydrocarbons: new routes to polyolefin/LDH nanocomposites (2012)

We report a simple and cost effective solvent treatment method for the synthesis of a stable and transparent dispersion of the hydrophilic layered double hydroxide, [Mg(6)Al(2)(OH)(16)](CO(3)) in non-polar hydrocarbon solvents. This dispersion can be used to make polyolefin/LDH nanocomposites using a simple solvent mixing method.
Acoustic sensing and signal processing techniques for monitoring milk fouling cleaning operations (2015)

[This corrects the article DOI: 10.1002/elsc.201400235.].
Intrinsic defects and conduction characteristics of Sc<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>2</mml:mn></mml:msub></mml:math>O<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mrow/><mml:mn>3</mml:mn></mml:msub></mml:math>in thermionic cathode systems (2012)

Recent experimental observations indicate that bulk Sc${}_{2}$O${}_{3}$ (\ensuremath{\sim}200 nm thick), an insulator at room temperature and pressure, must act as a good electronic conductor during thermionic cathode operation, leading to the observed high emitted current densities and overall superior emission properties over conventional thermionic emitters which do not contain Sc${}_{2}$O${}_{3}$. Here, we employ ab initio methods using both semilocal and hybrid functionals to calculate the intrinsic defect energetics of Sc and O vacancies and interstitials and their effects on the electronic properties of Sc${}_{2}$O${}_{3}$ in an effort to explain the good conduction of Sc${}_{2}$O${}_{3}$ observed in experiment. The defect energetics were used in an equilibrium defect model to calculate the concentrations of defects and their compensating electron and hole concentrations at equilibrium. Overall, our results indicate that the conductivity of Sc${}_{2}$O${}_{3}$ solely due to the presence of intrinsic defects in the cathode operating environment is unlikely to be high enough to maintain the magnitude of emitted current densities obtained from experiment, and that the presence of impurities is necessary to raise the conductivity of Sc${}_{2}$O${}_{3}$ to a high enough value to explain the current densities observed in experiment. The necessary minimum impurity concentration to impart sufficient electronic conduction is very small (approximately 7.5 \ifmmode\times\else\texttimes\fi{} 10${}^{\ensuremath{-}3}$ ppm) and is probably present in all experiments.
Low Overhead Architectures for OMP Compressive Sensing Reconstruction Algorithm (2017)

Orthogonal Matching Pursuit (OMP) is an important compressive sensing (CS) recovery and sparsity inducing algorithm, which has potential in various emerging applications ranging from wearable and mobile computing to real-time analytics processing on servers. Thus application aware OMP algorithm implementation is important. In this paper, we propose two different modifications to OMP algorithm named Thresholding technique for OMP (tOMP) and Gradient Descent OMP (GDOMP) to reduce hardware complexity of OMP algorithm. tOMP modifies identification stage of OMP algorithm to reduce reconstruction time and GDOMP modifies residual update phase to reduce chip area. To demonstrate reconstruction efficiency of proposed OMP modifications, we compare signal-to-reconstruction error rate (SRER), signal-to-noise ratio (PSNR), and Structural Similarity index (SSIM) of previously proposed matching pursuit algorithms such as Subspace Pursuit (SP), Look Ahead OMP (LAOMP), and OMP, with tOMP, and GDOMP. We implemented reconfigurable, parallel, and pipelined architectures for three algorithms including OMP, tOMP, and GDOMP which can reconstruct different data vector sizes ranging from 128 to 1024, on 65 nm CMOS technology operating at 1 V supply voltage. The post place and route analysis on area, power, and latency show that, tOMP requires 33% less reconstruction time, and GDOMP consumes 44% less chip area when compared to OMP ASIC implementation. Compared to previously published work, the proposed architectures achieve 2.1 times improvement in Area-Delay product (ADP) and consume 40% less energy.
Gold Glyconanoparticles as Water-Soluble Polyvalent Models To Study Carbohydrate Interactions This work was supported by the DGICYT (PB96-0820), J.M.F. thanks the MEC for a predoctoral fellowship. A.G.B. thanks CSIC for financial support. We thank Prof. Martín-Lomas for his scientific and financial support. (2001)

Glycosphingolipid clustering and interactions at the cell membrane can be modeled by gold glyconanoparticles prepared with biologically significant oligosaccharides. Such water-soluble gold glyconanoparticles with highly polyvalent carbohydrate displays (see picture, gray hemisphere: gold nanoparticle) have been obtained by a simple and versatile strategy.
<i>N</i> -Acylated Derivatives of Sulfamethoxazole and Sulfafurazole Inhibit Intracellular Growth of Chlamydia trachomatis (2014)

Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.
First-line assessment of patients with chronic liver disease with non-invasive techniques and without recourse to liver biopsy (2010)

It was initially an error that led me to develop non-invasive biomarkers of liver diseases [1]. After perforating the gallbladder of a friend in 1990, I wished that one day the assessment of patients with chronic liver disease could be carried out rapidly with noninvasive techniques and without the use of a liver biopsy. My first biomarker had no industrial development [2] but the others thereafter had professional developments, such as FibroTest with 500,000 tests prescribed worldwide in the last 7 years [3]. Twenty years later, it seems that there is little controversy concerning the utility of the most validated biomarkers versus biopsy [4–6]. Over the last 7 years, the opinions of more than 50 leaders from Nid Afdhal [7] to Vlad Ratziu [8] have been published on these biomarkers. From the evidence-based data, I will summarize my understanding of the main points of agreement and disagreement in 2010 and the main priorities for the years ahead.
Gigahertz voltage-controlled ring oscillator (1986)

Designs for ring oscillators that provide a 2:1 range of voltage-controllable frequency are compared. Simulated results are given for a ring oscillator intended for a 1 μm NMOS monolithic IC implementation. The circuit displays a variable frequency from 1.5 GHz to 2.5 GHz, and requires no off-chip tuning elements.
The Stuttering Progress of Cell Therapy for Heart Disease (2011)

Stem cell therapy has emerged as a potential therapeutic strategy for myocardial infarction (MI). Multiple cell types used to regenerate the injured heart have been tested in clinical trials. The results of studies of skeletal myoblasts (SKMs) have been resoundingly negative, and the bone marrow-derived-cell experience leaves much to be desired. A number of lessons arise from the large-scale bone marrow-derived-cell trials: (i) efficacy has been inconsistent and, overall, modest; however, unexpectedly meaningful benefits on clinical end points have been reported; (ii) cardiac engraftment of cells is disappointingly low, and delivery methods need to be optimized and combined with strategies to boost retention; (iii) the cardiomyogenic potential of bone marrow cells is low; however, functional benefit can be achieved through indirect pathways; and (iv) autologous cell therapy has severe limitations; highly standardized allogeneic cell products are attractive. Given the spotty trajectory of cell therapy to date, a more systematic approach to product development and preclinical optimization will facilitate more effective clinical translation.
Convenient, Cost‐Effective, and Mild Method for the N‐Acetylation of Anilines and Secondary Amines. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Privacy-preserving distributed mining of association rules on horizontally partitioned data (2004)

Data mining can extract important knowledge from large data collections ut sometimes these collections are split among various parties. Privacy concerns may prevent the parties from directly sharing the data and some types of information about the data. We address secure mining of association rules over horizontally partitioned data. The methods incorporate cryptographic techniques to minimize the information shared, while adding little overhead to the mining task.
A March-based fault location algorithm for static random access memories (2003)

A March-based fault location algorithm is proposed for repair of word-oriented static RAMs. A March algorithm of complexity 12N, N is the number of memory words, is defined for fault detection and partial diagnosis. A 3N or 4N March-like algorithm is used for location of the aggressor words of inter-word state, idempotent, inversion, write-disturb coupling faults (CF). Then another March-like algorithm of complexity 9(1 + logB), B is the number of bits in the word, is applied to locate the aggressor bit in the aggressor word. Finally, a March algorithm of complexity 6(1 + logB)N is used to detect and locate intra-word stuck-at, transition faults, as well as CFs. The proposed algorithm has higher fault location ability and lower time complexity than other known algorithms developed for fault location in SRAMs.
Systems biotechnology for protein production in Pichia pastoris (2017)

The methylotrophic yeast Pichia pastoris (syn. Komagataella spp.) is one of the most important production systems for heterologous proteins. After the first genome sequences were published in 2009, tremendous effort was made to establish systems-level analytical methods. Methylotrophic lifestyle was one of the most thoroughly investigated topics, studied at the levels of transcriptome, proteome and metabolic flux. Also the responses of P. pastoris to environmental stress conditions experienced during high cell density production processes were studied. Metabolomics and flux analysis revealed the plasticity of the cellular metabolism in its adaption to the production of foreign proteins and served as blueprints for subsequent cell engineering and/or process design. The transcriptional response elicited by overexpression of heterologous proteins seems to depend on the nature and complexity of the recombinant product. Based on these data, novel targets for strain engineering could be deduced from transcriptomics and proteomics data mining and effectively enhanced protein secretion. Transcriptional regulation data also served as a valuable resource to identify novel promoters with the desired regulatory characteristics. This review aims to provide a comprehensive overview of systems biology applications in P. pastoris ranging from increased understanding of cell physiology to improving recombinant protein production in this cell factory.
Avermectins in insect control and biology: a review (1987)

Abstract In a variety of laboratory and field experiments, avermectins have been tested against some 84 species of insects in ten orders, most of which are pests of livestock or horticultural crops or are of general nuisance value. This work is reviewed, comparing doses used, methods of application, and responses of the insects. Avermectins (abamectin and ivermectin) are toxic to almost all insects examined, although tolerance varies and death can be uncommonly slow, taking 24 h to 30 days. There is a marked absence of information on physiological processes that are affected by the pesticides, although at the cellular level they are thought to disrupt receptors for y-aminobutyric acid and glutamic acid in the central nervous system and muscular system. At high doses, treated insects are progressively immobilized, and although initially many can move when stimulated, this ability becomes lost. Some show a disturbed water balance and become distended with fluid, while others show disruption of moulting and metamorphosis. Feeding inhibition is commonly observed at sub-lethal doses. Avermectins affect many aspects of reproduction including mating behaviour, egg development, oviposition and egg hatching. The possibility is raised that these diverse disturbances are not all due to disruption of neuromuscular or central nervous system synapses, and the need for work in this area is stressed. Field studies have shown ivermectin to be most valuable in eradicating insect pests of livestock, but the use of abamectin against horticultural pests has produced less impressive results. The limited work on non-target species is discussed, and attention is drawn to some possible environmental consequences of excreted ivermectin on dung-breeding insects.
Photovoltaic chiral magnetic effect in Weyl semimetals (2016)

We theoretically predict current generation in Weyl semimetals when circularly polarized light is applied. The electric field of the light can drive an effective magnetic field on the order of 10 T. For lower-frequency light, a nonequilibrium spin distribution is formed near the Fermi surface. Spin-momentum locking induces a giant electric current proportional to the effective magnetic field. In contrast, higher-frequency light realizes a quasistatic Floquet state with no induced electric current. We discuss the relevant materials and estimate the order of magnitude of the induced current.
Partial para-Migration in the Allylic Rearrangement of o-Acetamidophenyl Allyl Ether and of o-Aminophenyl Allyl Ether (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartial para-Migration in the Allylic Rearrangement of o-Acetamidophenyl Allyl Ether and of o-Aminophenyl Allyl EtherBurris D. TiffanyCite this: J. Am. Chem. Soc. 1948, 70, 2, 592–594Publication Date (Print):February 1, 1948Publication History Published online1 May 2002Published inissue 1 February 1948https://pubs.acs.org/doi/10.1021/ja01182a043https://doi.org/10.1021/ja01182a043research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Room Temperature Direct Band Gap Emission from Ge p-i-n Heterojunction Photodiodes (2012)

Room temperature direct band gap emission is observed for Si-substrate-based Ge p-i-n heterojunction photodiode structures operated under forward bias. Comparisons of electroluminescence with photoluminescence spectra allow separating emission from intrinsic Ge (0.8 eV) and highly doped Ge (0.73 eV). Electroluminescence stems from carrier injection into the intrinsic layer, whereas photoluminescence originates from the highly n-doped top layer because the exciting visible laser wavelength is strongly absorbed in Ge. High doping levels led to an apparent band gap narrowing from carrier-impurity interaction. The emission shifts to higher wavelengths with increasing current level which is explained by device heating. The heterostructure layer sequence and the light emitting device are similar to earlier presented photodetectors. This is an important aspect for monolithic integration of silicon microelectronics and silicon photonics.
Simulations of Optical Leaky Waveguide Structures by the Vector Beam Propagation Method (1992)

Leaky waveguide structures have received great interest lately and several novel devices based on the leaky waveguides have been proposed and demonstrated. For instance, the low-loss ARROW devices have been fabricated on various materials and can be used as a polarizer [1]. ARROW or Bragg-reflection waveguides (BRW) can be used to build strongly coupled directional couplers with large separation [2]. The leaky waveguide structures can also be used in the detector design to achieve efficient absorption [3].
SSR mapping of stripe rust resistance gene from <I>Ae.tauschii</I> (2008)

A dominant wheat stripe rust resistance gene, temporarily designated as YrY201, was identified in an accession Y201 of Aegilops tauschii. By bulk segregation analysis, three microsatellite markers Xgwm273b, Xgwm37 and Wmc14 were found to be linked to YrY201 with genetic distance of 11.5, 5.8 and 10.9 cM , respectively. According to the locations of the linked markers, the resistance gene was located on chromosome 7DL. Based on the chromosomal location and the resistance pattern of the gene, we proposed that YrY201 was a novel stripe rust resistance gene, and could be selected by marker-assisted selection.