gebhart/patrepeval huggingface dataset:
Bandit Algorithms for Tree Search (2014)

Bandit based methods for tree search have recently gained popularity when applied to huge trees, e.g. in the game of go [6]. Their efficient exploration of the tree enables to re- turn rapidly a good value, and improve preci- sion if more time is provided. The UCT algo- rithm [8], a tree search method based on Up- per Confidence Bounds (UCB) [2], is believed to adapt locally to the effective smoothness of the tree. However, we show that UCT is "over-optimistic" in some sense, leading to a worst-case regret that may be very poor. We propose alternative bandit algorithms for tree search. First, a modification of UCT us- ing a confidence sequence that scales expo- nentially in the horizon depth is analyzed. We then consider Flat-UCB performed on the leaves and provide a finite regret bound with high probability. Then, we introduce and analyze a Bandit Algorithm for Smooth Trees (BAST) which takes into account ac- tual smoothness of the rewards for perform- ing efficient "cuts" of sub-optimal branches with high confidence. Finally, we present an incremental tree expansion which applies when the full tree is too big (possibly in- finite) to be entirely represented and show that with high probability, only the optimal branches are indefinitely developed. We illus- trate these methods on a global optimization problem of a continuous function, given noisy values.
Review of the Factors Affecting Bioavailability of Soy Isoflavones in Humans (2007)

Soy isoflavones have anticarcinogenic, antioxidant, and antiatherosclerotic activities. They also interact with the estrogen receptor, which makes them weak or moderate phytoestrogens. Because of their bioactivity, isoflavone bioavailability has been extensively studied in humans. This review summarizes data from intervention studies in humans, focusing on the factors that affect bioavailability. Summarizing data from 16 studies shows that the maximum concentration in plasma normalized to a constant dose of genistin is approximately 1.6 times that of genistein, and daidzin is approximately 1.8-fold higher than daidzein, whereas the half-life is not significantly different for aglycone and glucoside. There is a wide variation in the reported percentage urinary excretion that is not dependent on dose. Bioavailability is increased by a rapid gut transit time and by low fecal digestion rates and is decreased by a fiber-rich diet. There is no difference in bioavailability between pre- and postmenopausal women. The daily ingestion of soymilk for 1 wk does not affect bioavailability, but daily ingestion for a month increases excretion of equol in women. The factors or habitual diet characteristics that influence equol production are not clear, but equol production is limited with an immature flora. There is no consensus on which source of isoflavones results in the highest isoflavone bioavailability, and published studies present different results, although bioavailability is affected by whether the dose is given as food or drink. In conclusion, it is important to consider the factors affecting bioavailability of isoflavones when designing intervention studies.
Methane dehydro-aromatization over Mo/HZSM-5 catalyst prepared by different methods (2001)

Mo/HZSM-5 is a typical catalyst for methane dehydro-aromatization in the absence of oxygen. The catalyst was prepared with impregnation method in previous studies. In this paper, mechanical mixing, solid reaction and microwave methods were used for Mo/HZSM-5 preparation. In addition, the catalytic performance of the catalyst for methane dehydro-aromatization was investigated. Compared with impregnated Mo/HZSM-5 sample, the catalyst samples prepared with mechanical mixing, solid reaction and microwave methods show higher selectivity for aromatics and lower selectivity for coke. BET, XRD and NH3TPD experimental results exhibited that the location of Mo species is heavily dependent on the preparation method. It is suggested that the Mo species located on the external surface of the zeolite is more efficient for methane dehydro-aromatization, and at the same time suppresses the coke formation.
The Sakurai Reaction of 4-Acetoxycyclopentenone - Synthesis of <i>trans</i>-3-Allyl-4-vinylcyclopentanone (1999)

The Sakurai reaction of 4-acetoxycyclopentenone 1a leads to the aldol 2 and the bicyclic product 3. Retroaldol reaction leads to 4-allylcyclopentenone 7, from which the title compounds 9 was prepared in 28% overall yield. Further transformations of 3 are reported.
Slow light in photonic crystals (2006)

The problem of slowing down light by orders of magnitude has been extensively discussed in the literature. Such a possibility can be useful in a variety of optical and microwave applications. Many qualitatively different approaches have been explored. Here we discuss how this goal can be achieved in linear dispersive media, such as photonic crystals. The existence of slowly propagating electromagnetic waves in photonic crystals is quite obvious and well known. The main problem, though, has been how to convert the input radiation into the slow mode without losing a significant portion of the incident light energy to absorption, reflection, etc. We show that the so-called frozen mode regime offers a unique solution to the above problem. Under the frozen mode regime, the incident light enters the photonic crystal with little reflection and, subsequently, is completely converted into the frozen mode with huge amplitude and almost zero group velocity. The linearity of the above effect allows the slowing of light regardless of its intensity. An additional advantage of photonic crystals over other methods of slowing down light is that photonic crystals can preserve both time and space coherence of the input electromagnetic wave.
NMR and ESR characterization of oil shales (1984)

It has been shown that relaxation measurements can be useful in characterizing motions in oil shales. High-temperature T/sub 1 rho/ measurements have been shown to be especially useful in showing molecular motions that may be related to the oil producing aliphatic part of the shale. However, in order to more fully exploit relaxation measurements, a more fundamental understanding of the relaxation mechanisms must be obtained. Because the ESR spectra of the Eastern oil shales have been found to be so rich in detail, it may be possible to learn more about the nature of the free radicals in shale than is now known for coal, which has been studied much more extensively. Clearly, additional work on this subject should prove fruitful.
A novel deep learning driven, low-cost mobility prediction approach for 5G cellular networks: The case of the Control/Data Separation Architecture (CDSA) (2019)

One of the fundamental goals of mobile networks is to enable uninterrupted access to wireless services without compromising the expected quality of service (QoS). This paper reports a number of significant contributions. First, a novel analytical model is proposed for holistic handover (HO) cost evaluation, that integrates signaling overhead, latency, call dropping, and radio resource wastage. The developed mathematical model is applicable to several cellular architectures, but the focus here is on the Control/Data Separation Architecture (CDSA). Second, data-driven HO prediction is proposed and evaluated as part of the holistic cost, for the first time, through novel application of a recurrent deep learning architecture, specifically, a stacked long-short-term memory (LSTM) model. Finally, simulation results and preliminary analysis reveal different cases where non-predictive and predictive deep neural networks can be effectively utilized, based on HO management requirements. Both analytical and machine learning models are evaluated with a benchmark, real-world dataset measuring human behaviors and interactions. Numerical and comparative simulation results demonstrate the potential of our proposed deep learning-driven HO management framework, as a future benchmark for the mobile networking and machine learning communities.
BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice (2019)

Recent studies show branched-chain amino acid (BCAA) catabolic pathway is defective in obese animals and humans, contributing to the pathogenesis of insulin resistance and diabetes. However, in the context of obesity, various processes including the dysfunctional lipid metabolism can affect insulin sensitivity and glycemic regulation. It remains unclear how BCAA catabolic defect may exert direct impacts on glucose metabolism without the disturbance of obesity. The current study characterized the glucose metabolism in lean mice in which the genetic deletion of PP2Cm leads to moderate BCAA catabolic defect. Interestingly, compared to the wildtype control, lean PP2Cm deficient mice showed enhanced insulin sensitivity and glucose tolerance, lower body weight, and the preference for carbohydrate over lipids utilization. Metabolomics profiling of plasma and tissues revealed significantly different metabolic patterns in the PP2Cm deficient mice, featured by the marked alterations in glucose metabolic processes, including gluconeogenesis/glycolysis, glycogen metabolism, and tricarboxylic acid cycle. The metabolic changes of glucose were predominantly observed in liver but not skeletal muscle or white adipose tissue. The elevated branched-chain keto acids (BCKAs) resulted from the BCAA catabolic defect may play a critical role in regulating the expression of key regulators of glucose metabolic processes and the activity of respiratory Complex II/succinate dehydrogenase in TCA cycle. Together, these results show BCAA catabolic defect significantly alters glucose metabolism in lean mice with some impacts different or even opposite from those in obese mice, highlighting the critical role of BCAA catabolism in glycemic regulation and the complex interplay between macronutrients in lean and obese animals.
Noninvasive and Localized Blood—Brain Barrier Disruption using Focused Ultrasound can be Achieved at Short Pulse Lengths and Low Pulse Repetition Frequencies (2010)

Ultrasound methods in conjunction with microbubbles have been used for brain drug delivery, treatment of stroke, and imaging of cerebral blood flow. Despite advances in these areas, questions remain regarding the range of ultrasound parameters that disrupt the blood-brain barrier (BBB). In this study, several conditions were investigated to either enhance or reduce the likelihood of BBB disruption. Pulsed focused ultrasound (frequency: 1.5 MHz, pressure: 0.46 MPa, pulse repetition frequency (PRF): 0.1 to 25 Hz, pulse length (PL): 0.03 to 30 milliseconds) was noninvasively and locally administered to a predetermined region in the left hemisphere in the presence of circulating preformed microbubbles (Definity, Lantheus Medical Imaging, N. Billerica, MA, USA; 0.01, 0.05, 0.25 μL/g). Trans-BBB delivery of 3-kDa dextran was observed at PRFs as low as 1 Hz, whereas consistent delivery was observed at 5 Hz and above. Delivery was demonstrated at a PL as low as 33 microseconds. Although the delivered dextran concentration increased with the PL, this also increased the heterogeneity of the resulting distribution. In conclusion, key parameters that disrupt the BBB were identified out of a wide range of conditions. Reducing the total number of emitted acoustic cycles by shortening the PL, or decreasing the PRF, was also found to facilitate a more spatially uniform distribution of delivered dextran.
Behavioral Consequences of Overbooking Service Capacity (2007)

As a consequence of implementing revenue management systems, many service firms (e.g., airlines, hotels, car rentals) systematically overbook capacity, thus striving to maximize the revenue at one particular point in time (i.e., one flight, one night, and one day). The academic literature has not addressed how customers behaviorally respond to overbooking experiences, such as downgrading, denied service, or upgrading. In this article, the authors use the econometric technique of conditional difference-in-differences analysis to study the effect of such incidences on customer usage patterns in an airline context. They find that customers who experience negative consequences of revenue management significantly reduce the amount of their transactions with the airline, whereas upgraded customers exhibit only weak positive responses. The effects of the negative events are stronger for high-value customer groups, whereas significant effects of positive events can be found only for a low-value customer group. The results suggest the need for a stronger focus on customer reactions to revenue management practices. On a more general level, the study contributes to a more interdisciplinary view of service management by demonstrating the need for a closer interaction between management functions (e.g., marketing and operations) in developing and managing concepts of companywide importance.
Reducing the interference between sidelobe cancellers and sidelobe blankers in electronic scanning array radars (2003)

The interferometer effects that result from combining SLB (sidelobe blanker) and SLC (sidelobe canceller) auxiliary antennas threaten the compatibility of the two functions within a single radar system. An investigation of techniques to reduce or eliminate these effects is presented. Descriptions are presented of the simulation models (which consisted of planar arrays and cylindrical arrays), analytical approach, and results of the study. The results from early tests of two techniques-namely aperture switching and jammer assignment or beam switching of steerable auxiliaries on a pulse-to-pulse basis during the duration of a pulse burst-unmistakably indicate that the interference effects can be reduced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CHARACTERIZATION OF SPLENIC LYMPHOID CELLS IN FETAL AND NEWBORN MICE (1973)

In order to clarify the cellular events that precede the onset of immunological competence in the mouse, we have characterized and quantitated the lymphoid cells of the spleen as a function of age. Our results show that T cells and B cells both appeared in the spleens of Swiss-L mice as early as the 15th-16th day of gestation. Antigen-binding cells specific for each of three different antigens were also first detected during this same 24 h interval. The B cells and three varieties of antigen-binding cells increased in number rapidly and in parallel until about 1 wk after birth. The T cells, which were more numerous than B cells at first, increased in number somewhat more slowly. Coincident with the onset of response to antigen, there was a further increase in B cell numbers and a decrease in the T cell to B cell ratio. The capacity to respond to antigen by cellular proliferation and synthesis of antibody did not arise until about 2 wk after birth although there were no quantitative changes in the total numbers of T cells, B cells, and antigen-binding cells between 1 and 2 wk of age. Some qualitative change, such as the functional maturation of an antigen-reactive cell, may be required during this interval for the onset of this immunological response. Although the numbers of antigen-binding cells present in fetuses and young animals were smaller than in adults, we have as yet been unable to detect any restriction in the variety of specificities that can be expressed in fetuses, either in the kinds of antigens bound or in the range of avidities with which a single antigen is bound.
Photocyclizations of pharmacodynamic amines. II. X-ray analysis of a noncentrosymmetric tetracyclic indole (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclizations of pharmacodynamic amines. II. X-ray analysis of a noncentrosymmetric tetracyclic indoleOsamu Yonemitsu, Yohmei Okuno, Yuichi Kanaoka, Isabella L. Karle, and Bernhard WitkopCite this: J. Am. Chem. Soc. 1968, 90, 23, 6522–6523Publication Date (Print):November 1, 1968Publication History Published online1 May 2002Published inissue 1 November 1968https://pubs.acs.org/doi/10.1021/ja01025a056https://doi.org/10.1021/ja01025a056research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genetic organization and sequence analysis of the hypha-specific cell wall protein geneHWP1 ofCandida albicans (1998)

A previously isolated partial cDNA encoding a cell wall protein antigen found on hyphal surfaces of the opportunistic fungal pathogen, Candida albicans (Staab et al., 1996) was used to clone the complete hyphal wall protein 1 gene (HWP1). Hyphal forms of C. albicans invade mucosal surfaces of immunocompromised patients such as those with AIDS. HWP1 consisted of an open reading frame predicting an acidic protein (pI of 3.37) with a calculated molecular size of 61,122. The antigenic domain was located in the N-terminal third of the protein. The remainder of the protein contained abundant hydroxy amino acids, and terminated with a string of 15 amino acids typical of sequences specifying post-translational modification with glycosylphosphatidylinositol (6PI). The analyses suggested that Hwp1 is a glucan-linked protein with serine/threonine-rich regions that are predicted to function in extending a ligand-binding domain into the extracellular space.
Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide. (1988)

Extracellular matrix proteins and their proteolytic products have been shown to modulate cell motility. We have found that certain tumor cells display a chemotactic response to degradation products of the matrix protein elastin, and to an elastin-derived peptide, VGVAPG. The hexapeptide VGVAPG is a particularly potent chemotaxin for lung-colonizing Lewis lung carcinoma cells (line M27), with 5 nM VGVAPG eliciting maximal chemotactic response when assayed in 48-microwell chemotaxis chambers. Binding of the elastin-derived peptide to M27 cells was studied using a tyrosinated analog (Y-VGVAPG) to allow iodination. Scatchard analysis of [125I]Y-VGVAPG binding to viable M27 tumor cells at both 37 and 4 degrees C indicates the presence of a single class of high affinity binding sites. The dissociation constant obtained from these studies (2.7 X 10(-9) M) is equivalent to the concentration of VGVAPG required for chemotactic activity. The receptor molecule was identified as an Mr 59,000 species by covalent cross-linking of the radiolabeled ligand to the M27 tumor cell surface and subsequent analysis of the cross-linked material by electrophoresis and size-exclusion high performance liquid chromatography. These results suggest that M27 tumor cell chemotaxis to VGVAPG is initiated by high affinity binding of the peptide to a distinct cell surface receptor.
Morphologic demonstration of two stages in the development of type II collagen-induced arthritis. (1982)

The infrapatellar fat pad, fibrous synovium, and cartilage joint surfaces of the tibia, patella, and femur of the knee joints of 17 normal rats and 38 rats with type II collagen-induced arthritis were examined by light and electron microscopy. In the normal animals, the synovium covering the fat pad was structurally variable in that the mesothelium was flattened and two to three cell layers thick in the central region but rounded and three to five layers thick at the tibial and patellar ends. Large vacuoles were more numerous in the synovial cells at either end of the fat pad, and these cells contained less endoplasmic reticulum than those in the central region. The fibrous synovium consisted of a flattened mesothelium composed of cells similar to those found in the central region of the fat pad. The normal cartilage was not covered by a mesothelium. Knees from animals immunized with collagen showed no structural changes until 5 days after immunization, when fibrin could be detected in the synovium by immunofluorescence. By day 12, fibrin deposition was found throughout the synovium covering the fat pad and fibrous tissue, as well as over the cartilage. In addition, hyperplasia of the synovium over the soft tissues was present, and synovial cells extended over the cartilage. On day 19, in approximately 20 per cent of the animals, inflammatory infiltrates, composed of mixtures of polymorphonuclear leukocytes and mononuclear cells, were observed within the synovium covering the soft tissues. Infiltrates were also seen at the edges of the cartilage. When the 80 per cent of the animals that did not have cellular infiltrates were examined 30 days after immunization, neither hyperplasia nor fibrin deposition were seen by light microscopy. By day 45, in 20 per cent of the animals, the synovium was hyperplastic, and granulation tissue, scarring, and granulomata were found in the soft tissues. It is concluded that there are two distinct stages in the development of this synovial disease--the first is characterized by hyperplasia and fibrin deposition, and the second by the presence of inflammatory infiltrates.
Study of 2-Naphthol-Hexamethylenetetramine Condensation Products (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of 2-Naphthol-Hexamethylenetetramine Condensation ProductsW. J. Burke, M. J. Kolbezen, R. J. Reynolds, and G. A. ShortCite this: J. Am. Chem. Soc. 1956, 78, 4, 805–808Publication Date (Print):February 1, 1956Publication History Published online1 May 2002Published inissue 1 February 1956https://pubs.acs.org/doi/10.1021/ja01585a027https://doi.org/10.1021/ja01585a027research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts