gebhart/patrepeval huggingface dataset:
Sensitive integrated and time-resolved aerosol measurement by means of light-transmission changes of metal-coated Nuclepore filters (filter-fotometer) (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSensitive integrated and time-resolved aerosol measurement by means of light-transmission changes of metal-coated Nuclepore filters (filter-fotometer)Werner. Hollaender, Josef. Schoermann, Werner. Stoeber, Franz J. Moenig, and Norbert. SchwarzerCite this: Environ. Sci. Technol. 1981, 15, 4, 471–473Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/es00086a014https://doi.org/10.1021/es00086a014research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wavefront sets of solutions to linearised inverse scattering problems (1987)

A certain integral operator T, which arises in some linearised inverse scattering problems, is shown to be a pseudodifferential operator and its points of ellipticity are explicitly described. Consequently for the equation Tf=g, one can find the relationship between the wavefront sets of f and g. From this viewpoint a class of algorithms called the migration schemes and used extensively in geophysics for imaging the Earth's interior can be understood clearly.
Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription (2010)

CDK9/cyclin T1, a key enzyme in HIV-1 transcription, is negatively regulated by 7SK RNA and the HEXIM1 protein. Dephosphorylation of CDK9 on Thr(186) by protein phosphatase 1 (PP1) in stress-induced cells or by protein phosphatase M1A in normally growing cells activates CDK9. Our previous studies showed that HIV-1 Tat protein binds to PP1 through the Tat Q(35)VCF(38) sequence, which is similar to the PP1-binding RVXF motif and that this interaction facilitates HIV-1 transcription. In the present study, we analyzed the effect of expression of the central domain of nuclear inhibitor of PP1 (cdNIPP1) in an engineered cell line and also when cdNIPP1 was expressed as part of HIV-1 pNL4-3 in place of nef. Stable expression of cdNIPP1 increased CDK9 phosphorylation on Thr(186) and the association of CDK9 with 7SK RNA. The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription. Expression of cdNIPP1 as a part of the HIV-1 genome inhibited HIV-1 replication. Our study provides a proof-of-concept for the future development of PP1-targeting compounds as inhibitors of HIV-1 replication.
The Synthesis and Thermal Decomposition of Di-triethylmethyl, t-Butyl Pentamethylethyl and t-Butyl 1-Methylcyclohexyl-1 Peroxides<sup>1</sup> (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis and Thermal Decomposition of Di-triethylmethyl, t-Butyl Pentamethylethyl and t-Butyl 1-Methylcyclohexyl-1 Peroxides1Nicholas A. Milas and Lloyd H. PerryCite this: J. Am. Chem. Soc. 1946, 68, 10, 1938–1940Publication Date (Print):October 1, 1946Publication History Published online1 May 2002Published inissue 1 October 1946https://pubs.acs.org/doi/10.1021/ja01214a021https://doi.org/10.1021/ja01214a021research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adoptive Chemoimmunotherapy for the Treatment of Relapsed and Refractory Solid Tumors Using Ex Vivo Activated Memory T Cells (Autolymphocyte Therapy) and Cyclophosphamide (1993)

Autolymphocytes (ALT cells) are ex vivo activated peripheral blood lymphocytes (PBL) from tumor-bearing hosts (TBH) that consist primarily of tumor specific CD45RO+ (memory) T cells. These ALT cells combined with cimetidine as autolymphocyte therapy (ALT) have previously been demonstrated to be a safe and active form of outpatient adoptive immunotherapy (AIT) in human TBH with metastatic renal cell cancer (RCC). To determine activity of ALT in human TBH with therapy-resistant solid tumors other than RCC and whether it was feasible to combine ALT with chemotherapy, we studied 21 patients with relapsed or primary refractory solid tumors following a study protocol of adoptive chemoimmunotherapy (ACIT) using ALT and cyclophosphamide. Twenty patients were evaluable. Five responses were seen, including two complete responses (CRs) and three partial responses (PRs). ACIT activity was noted in relapsed TBH who had responded to their previous chemotherapy and/or radiation therapy. The toxic effects of this ACIT study were minimal with no treatment-related morbidity or mortality. It appears that in some relapsed but not primary refractory solid tumors, ACIT using ALT (CD45RO+ T cells and cimetidine) together with cyclophosphamide has definite antitumor activity associated with little or no toxic effects. Further studies of ACIT in solid tumors other than RCC are justified.
Oxygen Adsorption on Zinc Oxide Is Characterized by Time Domain Spectroscopy (1986)

For a (0001) single crystal in contact with a 0.25M phosphate buffer solution, the transient charging current was recorded by time domain spectroscopy as a function of bias potential. The analysis showed a multiexponential relaxation current due to different space‐charge capacities and interface resistances at different surface areas. The single relaxation currents were dependent on the buffer and on the oxygen concentration in solution, which was interpreted by the adsorption of phosphate ions and oxygen onto the semiconductor and a subsequent change in surface charge and interface resistance. For adsorbed oxygen on , the interface resistance approximately doubles and the adsorption may be potential dependent. By comparison with previous results, it is concluded that only a fraction of the semiconductor‐aqueous electrolyte interface is covered with hydroxyl ions.
Transform-limited photons from a tin-vacancy spin in diamond (2018)

Solid-state quantum emitters that couple coherent optical transitions to long-lived spin states are essential for quantum networks. Here we report on the spin and optical properties of single tin-vacancy (SnV) centers in diamond nanostructures. Through magneto-optical spectroscopy at 4 K, we verify the inversion-symmetric electronic structure of the SnV, identify spin-conserving and spin-flipping transitions, characterize transition linewidths, and measure electron spin lifetimes. We find that the optical transitions are consistent with the radiative lifetime limit and that the spin lifetimes are longer than for other inversion-symmetric color centers under similar conditions. These properties indicate that the SnV is a promising candidate for quantum optics and quantum networking applications.
Incremental Algorithm for Association Rule Mining under Dynamic Threshold (2019)

Data mining is essentially applied to discover new knowledge from a database through an iterative process. The mining process may be time consuming for massive datasets. A widely used method related to knowledge discovery domain refers to association rule mining (ARM) approach, despite its shortcomings in mining large databases. As such, several approaches have been prescribed to unravel knowledge. Most of the proposed algorithms addressed data incremental issues, especially when a hefty amount of data are added to the database after the latest mining process. Three basic manipulation operations performed in a database include add, delete, and update. Any method devised in light of data incremental issues is bound to embed these three operations. The changing threshold is a long-standing problem within the data mining field. Since decision making refers to an active process, the threshold is indeed changeable. Accordingly, the present study proposes an algorithm that resolves the issue of rescanning a database that had been mined previously and allows retrieval of knowledge that satisfies several thresholds without the need to learn the process from scratch. The proposed approach displayed high accuracy in experimentation, as well as reduction in processing time by almost two-thirds of the original mining execution time.
Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells [published erratum appears in J Cell Biol 1996 Dec;135(6 Pt 1):1679] (1996)

The current model of cytokinesis proposes that spindle poles and associated microtubules determine the cleavage plane, and, once the signal has been delivered to the cortex, the entire mitotic apparatus can be removed without affecting cell division. While supported by compelling data from Echinoderm embryos, recent observations suggest that the model may not be universally applicable. In this study, we have examined the relationship(s) among microtubules, chromosomes, and cleavage activity in living normal rat kidney (NRK) cells with multipolar mitotic figures. We found that cleavage activity correlated with the distribution of midzone microtubule bundles and Telophase Disc 60 protein (TD60) rather than the position of spindle poles. In addition, reduction of midzone microtubules near the cortex, by either nocodazole treatment or spontaneous reorganization in tripolar cells, caused inhibition or regression of furrowing. These results demonstrate that continuous interaction between midzone microtubule bundles and the cortex is required for successful cleavage in tissue culture cells.
The Use of Occlusion Training to Produce Muscle Hypertrophy (2009)

LOW-INTENSITY OCCLUSION (50-100 MM HG) TRAINING PROVIDES A UNIQUE BENEFICIAL TRAINING MODE FOR PROMOTING MUSCLE HYPERTROPHY. TRAINING AT INTENSITIES AS LOW AS 20% 1 REPETITION MAXIMUM WITH MODERATE VASCULAR OCCLUSION RESULTS IN MUSCLE HYPERTROPHY IN AS LITTLE AS 3 WEEKS. A TYPICAL EXERCISE PRESCRIPTION CALLS FOR 3 TO 5 SETS TO VOLITIONAL FATIGUE WITH SHORT REST PERIODS. THE METABOLIC BUILDUP CAUSES POSITIVE PHYSIOLOGIC REACTIONS, SPECIFICALLY A RISE IN GROWTH HORMONE THAT IS HIGHER THAN LEVELS FOUND WITH HIGHER INTENSITIES. OCCLUSION TRAINING IS APPLICABLE FOR THOSE WHO ARE UNABLE TO SUSTAIN HIGH LOADS DUE TO JOINT PAIN, POSTOPERATIVE PATIENTS, CARDIAC REHABILITATION, ATHLETES WHO ARE UNLOADING, AND ASTRONAUTS.
Outcome of radical multiple synovectomy as a novel surgical treatment for refractory rheumatoid arthritis: implication of HLA-DRB1*0405 in post-operative results. (1997)

RaMs provided good results in one-third of patients with refractory RA at a minimum of 3 years. HLA-DRB1*0405 may be a good marker to follow the effects of RaMS in RA patients.
Promoting medication adherence in children. (2006)

The problem of getting children to follow a treatment regimen is widespread and is frustrating for physicians. The extent to which any patient adheres to a medical regimen is an essential determinant of clinical success. Strategies to improve adherence in children include using simplified drug regimens (e.g., once-daily dosing), pleasant-tasting medicines, liquid or other nonpill formulations, regular phone contact between parents and physicians, reminders, information counseling, self-management plans, and other forms of individualized supervision or attention. Physicians also can encourage adherence by providing a dearly written explanation or patient information sheets that list generic and brand names, dosage, schedule, duration, and common side effects and practical ways of coping with them. Physicians, children, and parents should develop a mutually agreed-upon treatment plan. Having the child participate in devising the plan improves adherence.
Effects of Nano-silica/Nano-alumina on Mechanical and Physical Properties of Polyurethane Composites and Coatings (2013)

The present approach shows the use of nano-silica/nano-alumina in polyurethane (PU) matrix, which lead to significant improvements in the mechanical and thermal properties of the nano-composite. It is observed that with incorporation of 1% of nano-alumina into the PU matrix, there is an improvement in the tensile strength of around 50%, and for nano-silica the improvement is around 41%, at the same concentration. The morphological data shows that above 3% of the nano particles there are agglomerations in the nanocomposite. Again with the absorption of moisture, there is a decrease in the thermal and mechanical properties of the PU resin, but in this research work it is observed that with the incorporation of the nano particles, in the presence of absorbed moisture there is an improvement in mechanical and thermal properties of the composite, over that of the PU matrix.
Impact of Water-Assisted Electrochemical Reactions on the OFF-State Degradation of AlGaN/GaN HEMTs (2014)

The origin of structural and electrical degradation in AlGaN/GaN high-electron mobility transistors (HEMTs) under OFF-state stress was systematically studied. Hydroxyl groups (OH <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> ) from the environment and/or adsorbed water on the III-N surface, were found to play an important role in the formation of surface pits during OFF-state electrical stress. The mechanism of this water-related structural degradation is explained by an electrochemical cell formed at the gate edge where gate metal, the III-N surface, and the passivation layer meet. The relationship between structural and electrical degradation in AlGaN/GaN HEMTs under OFF-state stress is discussed. Specifically, the permanent decrease in the drain current is directly linked with the formation of the surface pits, while the permanent increase in the gate current is found to be uncorrelated with the structural degradation.
Global Pharmaceutical Policy (2009)

Pharmaceuticals play a central role in health care throughout the world. The pharmaceutical industry is beset with difficulties as increasing research and development expenditure yields fewer new treatments. Public and private budgets strain under the weight of high prices and limited access. The world's poor see little effort to address diseases prevalent in less affluent societies, while the world's wealthy are overusing prescription drugs, risking their health and wasting resources.
Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether.a-gogo K+ channel. (2001)

MCF-7 cells express voltage-activated K+ channels. In the present study, we used the patch-clamp and RT-PCR techniques to investigate the involvement of these channels during the cell cycle progression. The outward rectifier current (IK) recorded during depolarization was almost completely suppressed by the classical K+ channel blocker tetraethylammonium (TEA) in MCF-7 cells. TEA also inhibited cell proliferation, as measured with 3H-thymidine incorporation. Moreover, profound changes were observed in both the resting membrane potential (RMP) and IK during the release from the G0/G1 phase of the cell cycle. MCF-7 cells arrested in G0/G1 were depolarized (-26.3 +/- 10 mV, n = 30) and IK-density was small (9.4 +/- 5.6 pA/pF, n = 60) compared to cells progressing in the G1 phase (RMP = -60 +/- 7.9 mV; n = 35 and IK-density = 30.2 +/- 8.5 pA/pF; n = 76). IK was highly sensitive to Mg2+, astemizole and TEA (10 mM). Extracellular perfusion of 5 mM Mg2+ dramatically slowed the activation and perfusion of 2 microM astemizole inhibited both IK (20 +/- 3%) and cell proliferation (23%). Moreover, the h-EAG mRNA expression was modulated during the cell cycle. Thus, these data suggested that h-EAG K+ channels play a role in controlling the proliferation and/or cell cycle.
Chiral aspects of drug action at ion channels: A commentary on the stereoselectivity of drug actions at voltage‐gated ion channels with particular reference to verapamil actions at the Ca<sup>2+</sup> channel (1991)

Ion channels may be considered as pharmacological receptors possessing specific drug binding sites with defined structure-activity relationships. Accordingly drug binding to ion channels is stereoselective. Interpretation of this stereoselectivity may be complex because of the existence of differences in affinity and access to different channel states. Such state-dependent interactions may give rise to quantitative and qualitative differences in stereoselectivity. The implications of such differences are reviewed for drug action at Na+, K+ and Ca2+ channels. Detailed attention is paid to the actions of verapamil enantiomers in the cardiovascular system where activities differ in vascular and cardiac tissues because of state-dependent interactions and stereoselective first-oass metabolism.
Performance of multichannel wireless ad hoc networks (2006)

This paper addresses the design of Medium Access Control (MAC) protocols for wireless ad hoc networks that derive benefits from using multiple orthogonal channels for data transmission. Each node is assumed to have a single half-duplex transceiver that can dynamically select the best channel for transmitting data. We show that even with the same total bandwidth, multichannel MAC protocols can improve the throughput due to two factors – reduction of the number of backoffs during channel access, and increase of the probability of success of transmitted data packets by selecting channels to minimise co-channel interference. We propose multichannel MAC protocols with signal-power based channel selection for achieving these goals and present performance results that show that the proposed protocols can provide significantly higher throughput than that obtained by using the IEEE 802.11 MAC.
ThinStore: Out-of-Band Virtualization with Thin Provisioning (2011)

Traditional storage virtualization systems are faced with the problem of poor storage utilizations, leading to expensive capital expenditures and high energy consumptions. To address this issue, we design and implement Thin Store, an out-of-band virtualization system that supports thin provisioning of storage resources. Thin Store automatically allocates storage capacity only when new data is written and employs the probing reclamation policy to reclaim unused storage space. To improve the system performance, we introduce the mapping metadata caching and lazy update mechanisms to reduce the interaction overhead between the metadata server and clients. The experimental results demonstrated that Thin Store significantly improved the storage utilization with acceptable performance overhead. For example, it delivered approximately 88.7% storage space savings when file system utilization was 10%. We also examined the effectiveness of our reclamation policy. It reclaimed 83.6% of unused storage resources for a large file workload. In addition, various file systems showed different friendliness with our system. Compared with ext 3, ext 4 reduced the storage space overhead by 10.6% in a small file workload.
Synthesis and photophysical properties of Rhodamine B dye‐bearing poly(isobutyl methacrylate‐<i>co</i>‐2,2,2‐trifluoroethyl methacrylate) as a temperature‐sensing polymer film (2007)

Abstract To develop a novel temperature‐sensitive paint, methacrylamide monomers bearing Rhodamine B dye (two regioisomers, 3a and 3b ) were synthesized and polymerized with isobutyl methacrylate and 2,2,2‐trifluoroethyl methacrylate to afford Rhodamine B‐pendant polymers 4a and 4b . The methacrylamide monomers 3a and 3b showed photophysical properties almost identical with those of Rhodamine B. The temperature sensitivity of the luminescence intensity of 3a and 3b was also similar to that of Rhodamine B. The polymers 4a and 4b have excellent solubility in nonpolar organic solvents and are suitable for application as paint. Films of polymers 4a and 4b showed temperature‐dependent luminescence, which is applicable for temperature‐sensing. The temperature sensitivity of the film of 4a was estimated to be −0.37% °C −1 , and was independent of pressure. The film of 4b showed higher temperature sensitivity, but its temperature sensitivity was slightly pressure‐dependent. Hence, polymer 4a is expected to be superior for practical use in paints having temperature‐sensing functionality. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 2876–2885, 2007
Energy Efficiency of Load Balancing in MANET Routing Protocols (2005)

This paper considers energy constrained routing protocols and workload balancing techniques for improving MANET routing protocols and energy efficiency. We give new routing protocol that employs adaptive load balancing technique to the MANET routing protocols with node caching enhancement. Also, we show new application of energy efficiency metrics to MANET routing protocols for energy efficiency evaluation of the protocols with limited power supply. Our contributions include: (i) New energy efficient AODV-based node caching routing protocol with adaptive workload balancing (AODV-NC-WLB); (ii) New application of energy efficiency metrics to MANET routing protocols; and (iii) An implementation and simulation study in NS-2 of energy efficient AODV-NC-WLB sustaining considerable improvement in throughput, overhead, delivery ratio and delay over the standard AODV for high work load scenario.
Modified Stethoscope Earpiece Makes Excellent Gigli Saw Guide (1972)

From the Section of Orthopaedic Surgery, Department of Surgery, University of Kansas Medical Center, Kansas City
Reaction of diazonium salts with transition metals. Part 11. Palladium-catalyzed aryldesilylation of alkenylsilanes by arenediazonium salts (1986)

Under palladium(0) catalysis, both (E)- and (Z)-RCHCHSiMe3(RRh, 4-MeC6H4, 4-NO2C6H4, n-C6H13, and MeOCH2) were easily aryldesilylated by ArN2X (ArPh, 4-MeC6H4, 4-BrC6H4 and 4-NO2C6H4; XBF4, PF6, and Cl) to give (E)-RCHCHAr and RC(Ar)CH2 as the main products at 25 °C in acetonitrile. anti- and syn-1,2-Elimination of Pd(0) and Me3Si from the adducts, threo- and erythro-RCH(PdX)CHSiMe3, generated from ArPdX and (E) and (Z)-RCHCHSiMe3, respectively, are proposed for the formation of (E)-RCHCHAr from either isomer of RCHCHSiMe3.