gebhart/patrepeval huggingface dataset:
815. Nitrogen-containing carbohydrate derivatives. Part I. Methyl 4,6-O-benzylidene-3-deoxy-3-phenylazo-α-<scp>D</scp>-glucoside (1961)

R. D. Guthrie and L. F. Johnson, J. Chem. Soc., 1961, 4166 DOI: 10.1039/JR9610004166
Toward stochastic design for digital circuits - statistical static timing analysis (2005)

Due to the process variations and the variations of environmental factors such as supply voltage and temperature, the circuit parameters and hence the circuit performance such as delay fluctuate, and their variability and uncertainty are increasing in the deep sub-micron technology. Therefore, producing high performance digital circuits in high yield becomes difIicult more and more. Various efforts have heeu done in order to analyze and reduce such fluctuations. Among them, statistical static timing analysis has been studied intensively in these days, which finds the distribution of the critical delay when the distribution of the delay of each element in a circuit is given. Such a statistical analysis takes probability into consideration, and is different from the conventional design style treating deterministic values only. Hence, it can he called a stochastic design style, which fits to the concept of the yield. This paper surveys the statistical static timing analysis tools, and considers the expectations of stochastic design. In the deep sub-micron technology, numerous collaborations between design and process will he needed in order to increase the yield and to shorten the time-to-market. Therefore, stochastic design style may open a new vista in the digital circuit design.
Synthesis of Organosilicon Macrocycles. Palladium-Catalyzed Ring-Enlargement Oligomerization of Cyclic Disilanes via Si−Si σ-Bond Metathesis (1996)

Bis(tert-alkyl isocyanide)palladium(0) complexes catalyzed a ring-enlargement oligomerization of 1,1,2,2-tetramethyl-1,2-disilacyclopentane through Si−Si σ-bond metathesis to give cyclic oligomers up to the 40-membered octamer. The cyclic structure of the tetramer was established by the single-crystal X-ray diffraction method, which showed that the four Si−Si bonds of the tetramer were in a close to parallel arrangement. Reactivities of the dimer, trimer, and tetramer in the presence of bis(tert-butyl isocyanide)palladium(0) revealed that the present Si−Si σ-bond metathesis proceeded reversibly, in which the −Me2Si(CH2)3SiMe2− unit of the disilacyclopentane was successively inserted into the Si−Si bond of the oligomer to give higher oligomers. The intermediary 6-membered bis(organosilyl)bis(tert-alkyl isocyanide)palladium complex, which arose from oxidative addition of the disilacyclopentane onto bis(tert-alkyl isocyanide)palladium(0), was isolated and characterized by the single-crystal X-ray method. The insertion of the −Me2Si(CH2)3SiMe2− unit also occurred with linear disilanes and digermane to give linear oligomers. The cyclic trimer and tetramer reacted with 2,6-diisopropylphenyl isocyanide in the presence of Pd(OAc)2 to afford an 18-membered-ring triimine and 24-membered-ring tetraimine, respectively, in which the isocyanides were inserted into all the Si−Si linkages. Oxidation of the cyclic oligomers with trimethylamine oxide gave the corresponding cyclic oligo(disiloxane) species in quantitative yields. Unexpected polymerization of the disilacyclopentane occurred in the presence of the (η5-cyclopentadienyl)(η3-allyl)palladium(II) catalyst to give poly(Me2Si(CH2)3SiMe2) compounds with high molecular weights.
Nonlinear Liquid Rocket Combustion Instability Behavior Using UCDS Process (2010)

The Universal Combustion Device Stability™ (UCDS™) Process is the culmination of more than 40 years of research and provides the means to understand the complex dynamics and processes inside any chemical propulsion system, including rockets, turbojets and scramjets. With UCDS, it is now possible to accurately predict the time history of the pressure oscillation amplitudes during operation. This paper will provide an overview of the UCDS process as it is applied to liquid rocket engines. Using the UCDS nonlinear models a series of simulated bomb tests are used to explore the range of dynamic responses for a generic liquid rocket engine. These results reveal a wide range of complex dynamic responses that explain the widely varying instability effects seen in actual liquid rocket tests. When applied to the Corporal liquid rocket, this case study shows that the oscillatory behavior seen in the extensive testing of the Corporal rocket performed by JPL can be matched and clearly explained.
Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors (1989)

Mouse fibroblasts (3T3-L1 cells) accumulate detergent- and salt-insoluble aggregates of proteins conjugated to ubiquitin when incubated in the presence of inhibitors of lysosomal cysteine cathepsins, including E-64. These ubiquitin-protein conjugates co-fractionate with lysosomes on density gradients and are found in multivesicular dense bodies which by electron microscopy appear to be engaged in microautophagy. Both E-64 and ammonium chloride increase the intracellular concentration of free ubiquitin, but only E-64 leads to the formation of insoluble lysosomal ubiquitin-protein conjugates. The results are discussed in relation to the possible intracellular roles of ubiquitin conjugation.
Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102 (2007)

A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of its iminoindan precursor.
Molecular Modeling Applications in Crystallization (1999)

Crystallization is an important purification process used in a broad range of industries, including pharmaceuticals, foods, and bulk chemicals. In recent years, molecular modeling has emerged as a useful tool in the analysis and solution of problems associated with crystallization. Modeling allows more focused experimentation based on structural and energetic calculations instead of intuition and trial and error. This book is the first to offer a general introduction to molecular modeling techniques and their application in crystallization. After explaining the basic concepts of molecular modeling and crystallization, the book goes on to discuss how modeling techniques are used to solve a variety of practical problems related to crystal size, shape, internal structure, and properties. With chapters written by leading experts and an emphasis on problem-solving, this book will appeal to scientists, engineers, and graduate students involved in research and the production of crystalline materials.
Three-level broad-edge matching based real-time robot vision (2002)

This paper presents our real-time vision system for robots. The system employs a new internal image representation, in which the scene is encoded into three intensity level images. This representation is generated by Laplacian-Gaussian filtering followed by dual-thresholding. We refer to this image as three-level broad-edge representation. It reduces the computational cost of the normalized cross correlation. Thus the system performs the searching visual task as well as the object tracking task, which is not reliably achieved by the mean absolute error based correlators. Our prototype system achieves 32/spl times/32 pixel normalized cross correlation based matching from the 128/spl times/128 pixel search area in 2 ms under 9 MHz pixel clock image processor. This speed is fast enough for searching and tracking a single object at video frame rate.
Living in It, Living With It, and Moving on: Dimensions of Meaning During Chemotherapy (2002)

The study results suggest the potential value of exploring each woman's inner world of meanings in relation to her sense of self, relationships with others, resources, and coping strategies during treatment for breast cancer. Because existential and situational meanings are an integral part of women's experience, the nurse's role is to create an environment that permits and facilitates dialogue about these dimensions of meaning.
16 Antibodies as Tools to Probe Prion Protein Biology (1999)

Prion diseases are neurodegenerative disorders afflicting animals and humans that are characterized by progressive neurodysfunction and lead invariably to death. Prion diseases have been shown to be inheritable due to mutations in the chromosomal gene encoding the prion protein (PrP), to arise sporadically at low frequencies, or to be acquired through the transmission of infectious prion particles. These features are highly unusual in combination and hint at the unorthodox biological and physico-chemical properties of prion proteins. Early transmission studies provided clues that the infectious prion agent possessed properties not normally associated with a viral pathogen (Alper et al. 1966; Lartajet et al. 1970). It was some years later, however, before progressive enrichment of infectivity from fractions of diseased hamster brain first identified PrP as an integral component of the infectious scrapie agent (Prusiner 1982; Prusiner et al. 1982). Further investigation of prion disorders has unveiled a unique and unexpected molecular pathology, in which the central event is the aberrant metabolism of the ubiquitous cellular prion protein (PrP C ), the physiological function of which remains poorly understood (Brown et al. 1997; Martins et al. 1997; Rieger et al. 1997; Weiss et al. 1997). PrP C is a glycosyl-phosphatidylinositol (GPI) anchored protein composed of 209 amino acids and expressed on a wide variety of tissue types, particularly neurons. However, the disease state is typified by an accumulation in the brain of an abnormal protease-resistant isoform of PrP C , designated PrP Sc . Intensive scrutiny from diverse experimental perspectives has been directed toward unraveling the molecular events governing...
Pseudo-Correlation-Function-Based Unambiguous Tracking Technique for Sine-BOC Signals (2010)

The sine-BOC (binary offset carrier) modulation is used in several signals of the new European Global Navigation Satellite System, Galileo, and modernized GPS. It provides these signals with enhanced robustness against multipath and increases the precision of the range measurement. However, this modulation presents some drawbacks. The most severe is the ambiguity problem in acquisition and tracking, which introduces a large bias in the pseudo-range measurement. In order to solve this problem, an unambiguous tracking technique for sine-BOC signals is proposed. This technique is based on a pseudo correlation function (PCF) which does not have any side peak and thus completely removes all of the false lock points on the discriminator output. Impacts of thermal noise and multipath on the proposed technique are investigated. Theoretical and numerical results obtained with BOC(n,n) and BOC(2n,n) signals show that this technique has a good noise mitigation performance and an average multipath performance.
Acid Fracturing of Deep Gas Wells Using a Surfactant-Based Acid: Long-Term Effects on Gas Production Rate (2006)

Abstract The deep, tight carbonate formations in Saudi Arabia are ideally suited for acid fracturing treatments. Various types of acids such as regular, in-situ gelled, and emulsified acids, have been used in order to achieve optimum fracture length and conductivity. Acids used for these treatments were based on 28 wt% HCl. A mixture of 15 wt% HCl and 9 wt% formic acid was used in wells completed with super Cr-13 tubulars. A high pH borate gel was pumped in stages to reduce leak-off and maintain the bottomhole pressure at values greater than the fracturing pressure of the formation. A new generation of viscoelastic surfactant-based acid was implemented in the field. A short term production evaluation based on the initial production (post flowback) from these wells could not clearly distinguish between the benefits obtained from the viscoelastic diverting acid versus the in-situ gelled acid.1 However, the wells treated with viscoelastic surfactant based acid did clean out in a shorter period of time. The main objective of this study was to compare the "long term" production results obtained from five wells treated with the surfactant-based acid with off-set wells treated with in-situ gelled acids. This paper provides for the first time long term production data evaluation following acid fracturing using surfactant-based acids. It also compares the performance of two main acid systems based on field data. The evaluation of acid fracturing treatments with in-situ gelled acid systems and surfactant-based acid systems suggest that there was no significant variation in the design and the execution of both the viscoelastic and in-situ gelled acid treatments. Among the 5 wells treated with surfactant-based acid, 4 of them showed better long-term production performance over a 2-3 year period compared to their offset wells. In the short-term (nearly 3 months production), 2 wells treated with viscoelastic acid showed no difference in production performance compared to their offset wells.
The Diagnosis of Growth Hormone Deficiency in Children and Adults (1998)

A. Clinical aspects B. Radiology C. GH provocative tests D. Physiological assessment of GH secretion E. IGFs F. IGFBPs G. Newer strategies for assessment
Effect of Lactobacillus casei subsp. casei 327 on the Growth of Bifidobacteria and Its Survival in the Intestine (2004)

We tested the stimulative effect of Lactobacillus casei subsp. casei 327 isolated from rice on the growth of bifi-dobacteria. No effect on the in vitro growth of bifidobacteria was observed. The number of bifidobacteria and the relative percentage of bifidobacteria of 14 female volunteers with constipation were measured. Then 7 volunteers who had less than 1010 cfu/g of bifidobacteria were administered 100 g of fermented milk with L. casei subsp. casei 327 each day for 2 weeks. The number of bifidobacteria, the relative percentage of bifidobacteria and the number of lactobacilli during the administration period significantly increased compared to before that period. Seven male volunteers who evacuated everyday were administered fermented milk to determine the change in the number of intestinal lactobacilli. The number of lactobacilli significantly increased during the administration period and returned to the original level 5 days after administration. These results indicate that the administration of fermented milk with L. casei subsp. casei 327 improves the intestinal environment.
The effect of using different probiotic cultures on conjugated linoleic acid (CLA) concentration and fatty acid composition of white pickle cheese (2011)

Pickle white cheeses were produced from whole milk with five different probiotic cultures (Enterococcus faecium, Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium bifidum and Lactobacillus acidophilus). Conjugated linoleic acid (CLA) content of cheeses ranged from 3.52 to 3.92 mg/g. Probiotic differences and storage process have not affected the CLA contents of the samples statistically. There was no correlation between the CLA content of all probiotic cheeses and saturated fatty acids. A positive correlation between the CLA and linoleic acid contents of L. paracasei and L. acidophilus cheeses was observed.
Long-term Results of Arthroscopic Meniscal Repair (1995)

From 1984 through 1986 we performed 54 arthroscopic meniscal repairs on patients with anterior cruciate ligament-stable knees. We evaluated the repair results of 52 of these patients at an average followup of 7.5 years. In 40 patients the meniscal repairs had not failed and these patients were examined clinically and radiographically; in 25 cases, magnetic resonance imaging was also performed. Significantly more failures (P < or = 0.05) occurred when the rim width of the tear was greater than 3 mm and when the tear was repaired with resorbable sutures. Conversely, the following factors were found to favorably influence meniscal healing (P > 0.05); time from injury to surgery less than 8 weeks, patient age less than 30 years, tear length less than 2.5 cm, and tear in the lateral meniscus. The overall failure rate after 7.5 years was 27% (14 of 52); 64% (9 of 14) of the failures occurred in the first 6 months after repair. The clinical and radiographic evaluation of the successfully repaired knees showed that 90% (36 of 40) had normal knee function; the remaining 10% (4 patients) had nearly normal knee function. Magnetic resonance imaging, however, showed a persisting grade 3 or 4 lesion in 96% (24 of 25) of the successfully repaired menisci and is therefore not reliable in assessing meniscal healing.
Career matters: On the frontline (2013)

Deployed in Afghanistan, pharmacist Lt Nicole Such offers medical assistance on an international scale to save the lives of Australian soldiers.
Slow and small target detection in high sea states (2015)

This paper addresses the detection of small and slow craft with Maritime Radar. Fast target detection can be carried out using standard processing such as MMTI (Maritime Moving Target Indicator) regardless of the sea state. However, in case of slow moving targets in high sea state, these methods no longer work because of the intrinsic spreading of the sea clutter. After having summarized the statistical modelling of the sea clutter, in order to highlight its particularity especially when observed with high range resolution waveforms, the paper explains the interest of Track-Before-Detect (TBD) detectors for taking benefits of both high-resolution waveforms and sea clutter properties. Two TBD detectors are compared to standard detectors working on a single dwell.
Discussion on marketing strategies for medical facilities under the new environment (2017)

Abstract: After entering the 21st century, the economic and scientific and technological levels of China show a tendency of rapid rise. On account of it, medical level is also developing, and the requirements for medical institutes and equipments have become stricter. In recent years, the medical facility market in China is facing a complicated environment, and many traditional medical facilities have been gradually replaced. Medical marketing plays a crucial role in improving the position of Chinese medical facilities in the industry. In the perspective of the current new environment, this study investigated the marketing strategies of Chinese medical facilities, aiming to provide a reference for their positive development in the new environment.
Treatment of chronic non‐A, non‐B hepatitis with acyclovir: Pilot study (1985)

Five patients with chronic non-A, non-B hepatitis were entered into a pilot therapeutic study of the antiviral agent acyclovir [9-(2-hydroxyethoxymethyl)guanine]. Each patient received acyclovir by slow intravenous infusion in a dosage of 5 mg/kg every 8 hr for 10 days. During therapy, serum aminotransferase levels decreased by more than 50% in two patients, remained unchanged in two patients, and rose (by 32%) in the final patient. The two patients whose serum aminotransferase levels decreased during acyclovir treatment subsequently received a second course of drug using a higher dose (10 mg/kg every 8 hr for 10 days). Serum aminotransferase levels rose in both patients (by 54% and 121%) during the second course of therapy. Acyclovir was well tolerated in these patients, and there were no symptoms or signs attributable to drug toxicity during or after treatment. During a subsequent 12-month follow-up period, none of the five patients has manifested either a clinical or serum biochemical improvement in their chronic liver disease. Spontaneous fluctuations in serum aminotransferase levels unrelated to acyclovir therapy were noted in three of the five patients. These findings suggest that a short course of acyclovir does not have any appreciable long-term beneficial effect on the course of chronic non-A, non-B hepatitis.
Packed-Tube Heat Transfer (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPacked-Tube Heat TransferMax LevaCite this: Ind. Eng. Chem. 1950, 42, 12, 2498–2501Publication Date (Print):December 1, 1950Publication History Published online1 May 2002Published inissue 1 December 1950https://pubs.acs.org/doi/10.1021/ie50492a031https://doi.org/10.1021/ie50492a031research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Long-Term Impact of Promotion and Advertising on Consumer Brand Choice (1997)

The authors examine the long-term effects of promotion and advertising on consumers’ brand choice behavior. They use 8 1/4 years of panel data for a frequently purchased packaged good to address two questions: (1) Do consumers’ responses to marketing mix variables, such as price, change over a long period of time? (2) If yes, are these changes associated with changes in manufacturers’ advertising and retailers’ promotional policies? Using these results, the authors draw implications for manufacturers’ pricing, advertising, and promotion policies. The authors use a two-stage approach, which permits them to assess the medium-term (quarterly) effects of advertising and promotion as well as their long-term (i.e., over an infinite horizon) effects. Their results are consistent with the hypotheses that consumers become more price and promotion sensitive over time because of reduced advertising and increased promotions.
Probing Electrode Losses in All-Vanadium Redox Flow Batteries with Impedance Spectroscopy (2013)

We report on single-electrode electrochemical impedance spectroscopy studies of an all-vanadium redox battery using a dynamic hydrogen reference electrode. The negative electrode, comprising the V2+/V3+ couple, contributes approximately 80% of the total cell overpotential during discharge. The impedance spectra measured at the negative electrode exhibit high-frequency, semicircular arcs which correspond to the double layer capacitance in parallel with a faradaic resistance. The faradaic resistance decreases in magnitude with increasing polarization. Integration of the current-dependent faradaic resistance quantifies the fraction of the overvoltage that is attributed to the kinetic limitations of the charge transfer reaction.