gebhart/patrepeval huggingface dataset:
Emerging beneficial roles of sirtuins in heart failure (2012)

Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. In mammalian cells, seven sirtuins (SIRT1-7) modulate distinct metabolic and stress-response pathways, SIRT1 and SIRT3 having been most extensively investigated in the cardiovascular system. SIRT1 and SIRT3 are mainly located in the nuclei and mitochondria, respectively. They participate in biological functions related to development of heart failure, including regulation of energy production, oxidative stress, intracellular signaling, angiogenesis, autophagy and cell death/survival. Emerging evidence indicates that the two sirtuins play protective roles in failing hearts. Here, we summarize current knowledge of sirtuin functions in the heart and discuss its translation into therapy for heart failure.
Teaching and Programing for Robots. High Speed Target Tracking Algorithm for 1ms Visual Feedback System. (1999)

Most conventional visual feedback systems using CCD camera are restricted by video rates and therefore cannot be adapted to the changing environment sufficiently quickly. To solve this problem we developed a 1 ms visual feedback system using a general purpose massively parallel processing vision system in which photo-detectors and processing elements are directly connected. For high speed visual feedback fast image processing algorithms are also required. In particular, the difference of images between frames is very small in our system because of its high speed frame rate. Using this feature, we can realize several image processing techniques by simpler algorithms.In this paper we propose a simple algorithm for target tracking using the feature of high speed vision, and realize target tracking on the 1 ms visual feedback system.
AChord: Topology-Aware Chord in Anycast-Enabled Networks (2006)

Chord is a scalable peer-to-peer (P2P) lookup protocol that solves the problem of efficiently locating nodes with designed data items. However, Chord is known to be limited in routing efficiency since all nodes are placed on the overlay without taking into account the underlying network topology. In this paper, we introduce AChord, a topology-aware version of Chord that utilizes anycast, along with additional modifications, to achieve higher routing efficiency. Simutation results show that the proposed approach achieves better performance than the original Chord in the sense of end-to-end lookup latency and average path length.
Intramolecular electron-transfer rates in ferrocene-derivatized glucose oxidase (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular electron-transfer rates in ferrocene-derivatized glucose oxidaseAntonella Badia, Rina Carlini, Arthur Fernandez, Fernando Battaglini, Susan R. Mikkelsen, and Ann M. EnglishCite this: J. Am. Chem. Soc. 1993, 115, 16, 7053–7060Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00069a001https://doi.org/10.1021/ja00069a001research-articleACS PublicationsRequest reuse permissionsArticle Views920Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Weather-clustering based strategy design for dynamic demand response building HVAC control (2012)

Energy consumption and room temperature can be simulated using EnergyPlus model, given the building model, weather information, and HVAC control strategy. For a given weather forecast, however, online simulation-based optimization of the HVAC control strategy is time-consuming and thus impractical. In this paper we suggest to offline learn a compact candidate list of demand response (DR) HVAC control strategies that best cover potential weather variations. Training weather data is first clustered using a specially-designed hybrid method, and the resulting clusters are then used to supervise the sampling on the training weather data. The candidate list is formed as the union of all the optimal HVAC control strategies corresponding to the selected weather patterns. The proposed method is tested on real historical data (from Berkley and Phoenix), and is able to provide a strategy list that covers 95--100% weathers using only 8% of the computational cost of a brute-force search. In addition, the fitness function can be optimized up to 99.9% of the global optimum.
Performance and robustness analysis for structured uncertainty (1982)

This paper introduces a nonconservative measure of performance for linear feedback systems in the face of structured uncertainty. This measure is based on a new matrix function, which we call the Structured Singular Value.
Simulation Modeling for Optimized LWD Fluid Sampling Under Different Invasion Profiles (2012)

Abstract Understanding the properties of formation fluid is a critical step in reservoir characterization. The use of Logging While Drilling (LWD) based fluid sampling becomes increasingly important in high risk scenarios. The LWD environment is significantly different from that of Wireline (WL) for sampling operations as the dynamic filtrate invasion is still in effect. LWD sampling is a relatively new technology and its sampling efficiency compared to WL sampling is not well known. This study aims to understand the effects of dynamic invasion processes on LWD fluid sampling and compare its performance with WL based fluid sampling. The results of the simulation study performed revealed that when the wait time after the drilling is optimized, LWD can provide cleaner samples in shorter cleanup time than WL sampling. It also revealed that the reservoir fluid breakthrough time would be shorter in LWD sampling compared to that of WL. This study indicates that with proper modeling, an optimized sampling program can be executed to meet the objectives of the LWD sampling operations in the most economic manner.
KKT Solution and Conic Relaxation for Solving Quadratically Constrained Quadratic Programming Problems (2011)

To find a global optimal solution to the quadratically constrained quadratic programming problem, we explore the relationship between its Lagrangian multipliers and related linear conic programming problems. This study leads to a global optimality condition that is more general than the known positive semidefiniteness condition in the literature. Moreover, we propose a computational scheme that provides clues of designing effective algorithms for more solvable quadratically constrained quadratic programming problems.
Hydroxylation of Progesterone and 11-Desoxy-17-Hydroxycorticosterone by <i>Aspergillus</i> and <i>Penicillium</i> (1955)

by more than 99.9 per cent.Brilliant green was more effective against influenza A virus than against vac- cinia virus, whereas Igepon AP-78 was more effective against vaccinia virus than against influenza A virus.The limitations of the experimental method were discussed.
Media and Fermentation Processes for the Rapid Production of High Concentrations of Stable Blastospores of the Bioinsecticidal Fungus<i>Paecilomyces fumosoroseus</i> (2003)

In shake flask and fermentor studies, various media components and culture inocula were tested to improve P. fumosoroseus spore production rates, yield and stability. To evaluate inoculum potential and inoculum scale-up for fermentor studies, conidia and liquid culture-produced spores of various strains of P. fumosoroseus were compared as inoculum. Inoculation of liquid cultures with blastospores at concentrations of at least 1×106 spores mL−1 resulted in the rapid production of high concentrations of blastospores (∼1×109 spores mL−1, 48 h fermentation time) for all strains tested. The rapid germination rate of blastospores (90% after 6 h incubation) compared to conidia (>90% after 16 h incubation) and the use of higher inoculum rates reduced the fermentation time from 96 to 48 h for maximal spore yields. A comparison of various complex nitrogen sources showed that liquid media supplemented with acid hydrolyzed casein or yeast extract supported the production of high concentrations of blastospores that were significantly more desiccation-tolerant (79-82% survival after drying) when compared to blastospores produced in media supplemented with other nitrogen sources (12-50% survival after drying). For rapid spore production, requirements for trace metals and vitamin supplementation were dependent on the type of hydrolyzed casein used in the medium. Fermentor studies with two strains of P. fumosoroseus showed that high concentrations (1.3-1.8×109 spores mL−1) of desiccation-tolerant blastospores could be produced in 48-h fermentations. These studies have demonstrated that the infective spores of various strains of the fungal bioinsecticide Paecilomyces fumosoroseus can be rapidly produced using deep-tank, liquid culture fermentation techniques.
Translocation of bacterial DNA from Gram-positive microorganisms is associated with a species-specific inflammatory response in serum and ascitic fluid of patients with cirrhosis (2007)

Translocation of bacterial-DNA in patients with cirrhosis and ascites triggers an innate immune response. Identification of characteristics to which this response is sensitive is relevant from a clinical standpoint. The aim of this study has been to determine if the proinflammatory immune response established in vivo in cirrhotic patients with ascites as a consequence of bacterial-DNA translocation is related to the identified bacterial species and their frequency of cytosine-guanosine content in serum and ascitic fluid. Patients with advanced cirrhosis and ascites were included in the study and distributed into groups I and II according to the absence or presence of bacterial-DNA translocation, respectively. Serum and ascitic fluid levels of proinflammatory cytokines after normalization of bacterial-DNA concentration and the activated form of nuclear factor-kappa B in ascitic fluid pellets were measured by enzyme-linked immunosorbent assay techniques. Translocation of bacterial-DNA with higher cytosine-guanosine content induced the highest cytokine response, which was higher than that in patients without bacterial-DNA translocation. The activated form of nuclear factor-kappa B in ascitic fluid pellets of patients with bacterial-DNA translocation was greater in patients with higher bacterial-DNA cytosine-guanosine content, whereas the amount of total nuclear factor-kappa B remained unaltered. Bacterial-DNA translocation induces a marked immune reaction in vivo in patients with advanced cirrhosis and ascites which is related, among other factors, to the bacterial-DNA cytosine-guanosine content. Therefore, the host's immune response to bacterial-DNA translocation constitutes a species-specific phenomenon.
The ATLAS multi-user upgrade and potential applications (2017)

With the recent integration of the CARIBU-EBIS charge breeder into the ATLAS accelerator system to provide for more pure and efficient charge breeding of radioactive beams, a multi-user upgrade of the ATLAS facility is being proposed to serve multiple users simultaneously. ATLAS was the first superconducting ion linac in the world and is the US DOE low-energy Nuclear Physics National User Facility. The proposed upgrade will take advantage of the continuous-wave nature of ATLAS and the pulsed nature of the EBIS charge breeder in order to simultaneously accelerate two beams with very close mass-to-charge ratios; one stable from the existing ECR ion source and one radioactive from the newly commissioned EBIS charge breeder. In addition to enhancing the nuclear physics program, beam extraction at different points along the linac will open up the opportunity for other potential applications; for instance, material irradiation studies at ~1 MeV/u, isotope production and radiobiological studies at ~6 MeV/u and at the full ATLAS energy of ~15 MeV/u. The concept and proposed implementation of the ATLAS multi-user upgrade will be discussed. Future plans to enhance the flexibility of this upgrade will be presented.
Multi-axis integrated Hall magnetic sensors (2007)

Conventional Hall magnetic sensors respond only to the magnetic field component perpendicular to the surface of the sensor die. Multi-axis sensing capability can be provided in the following two ways: (a) by integrating magnetic flux concentrators on the die, and (b) by using vertical Hall devices. Here we review the most important two-and three-axis integrated Hall magnetic sensors based on these concepts. Their applications include mapping of magnetic fields and sensing angular position.
Foam Fractionation of Proteins: Potential for Separations from Dilute Starch Suspensions (1993)

Abstract Fundamentals of the separation of proteins from foam are reviewed. Thermodynamic, hydrodynamics and kinetic considerations of foam separation from protein mixtures are discussed as a guidance for operating and design parameters. They are useful for suggesting ways to apply this methodology to the starch industry. particularly in the area of protein (zein) removal from starch particles.
Model-Based Reinforcement Learning in Factored-State MDPs (2007)

We consider the problem of learning in a factored-state Markov decision process that is structured to allow a compact representation. We show that the well-known algorithm, factored Rmax, performs near-optimally on all but a number of timesteps that is polynomial in the size of the compact representation, which is often exponentially smaller than the number of states. This is equivalent to the result obtained by Kearns and Roller for their DBN-E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> algorithm, except that we've conducted the analysis in a more general setting. We also extend the results to a new algorithm, factored IE, that uses the interval estimation approach to exploration and can be expected to outperform factored Rmax on most domains
Cytoplasmic HuR Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma (2005)

HuR is a ubiquitously expressed mRNA-binding protein. Intracellular localization of HuR is predominantly nuclear, but it shuttles between the nucleus and the cytoplasm. In the cytoplasm it can stabilize certain transcripts. Because nucleocytoplasmic translocation of HuR is necessary for its activity, it was hypothesized that cytoplasmic HuR expression in cancer cells could be a prognostic marker. To test the significance of HuR in carcinogenesis of the breast, we have investigated HuR expression in a mouse mammary gland tumor model and from 133 invasive ductal breast carcinoma specimens. HuR expression was elevated in the cyclooxygenase-2 transgene-induced mouse mammary tumors, and its expression was predominantly cytoplasmic in the tumor cells. In the human carcinoma samples, high cytoplasmic immunoreactivity for HuR was found in 29% (38 of 133) of the cases. Cytoplasmic HuR expression associated with high grade (P = 0.0050) and tumor size over 2 cm (P = 0.0082). Five-year distant disease-free survival rate was 42% [95% confidence interval (95% CI), 26-58] in cytoplasm-high category and 84% (95% CI, 76-91) in cytoplasm-negative or -low category (P < 0.0001), and high cytoplasmic expression of HuR was an independent prognostic factor in a Cox multivariate model (relative risk 2.07; 95% CI, 1.05-4.07). Moreover, high cytoplasmic HuR immunopositivity was significantly associated with poor outcome in the subgroup of node-negative breast cancer in a univariate analysis (P < 0.0007). Our results show that high cytoplasmic HuR expression is associated with a poor histologic differentiation, large tumor size, and poor survival in ductal breast carcinoma. Thus, HuR is the first mRNA stability protein of which expression associates with poor outcome in breast cancer.
LOGISTIC REGRESSION IN SURVIVAL ANALYSIS (1985)

Logistic regression has been applied to numerous investigations that examine the relationship between risk factors and various disease events. Recently, the ability to consider the time element of event occurrences by proportional hazards models has meant that logistic regression has played a less important role in the analysis of survival data. This paper, however, shows that when event times are grouped into intervals, logistic regression can be adapted to the analysis of such data by modeling the interval when an event occurs. Furthermore, it is shown that results from such an adaptation will often lead to parameter estimates close to those obtained by the proportional hazards model in the grouped event time setting. An illustration of the application of logistic regression to survival analysis is based on data from the Framingham Heart Study.
Do Cultured Vascular Smooth Muscle Cells Resemble Those of the Artery Wall? If Not, Why Not? (1989)

Ultrastructural stereological techniques were used to quantitate the phenotype of vascular smooth muscle cells grown in primary culture on a plastic substrate (control), on and within matrices of collagen type I, and on collagen type III, collagen type IV, or basement membrane Matrigel. The volume fraction of myofilaments (Vv myo) of freshly isolated cells at day 0 was 54.2 +/- 2.0%. By day 5 in culture, the Vv myo of cells grown on plastic, on collagen type I, and collagen type III had decreased significantly to 14.2 +/- 2.1%, 16.5 +/- 2.4%, and 16.3 +/- 2.9%, respectively. In contrast, smooth muscle cells grown within matrices of collagen type I, on collagen type IV, or on basement membrane Matrigel had a Vv myo of 30.7 +/- 1.5%, 30.8 +/- 4.2%, and 32.1 +/- 3.1%, respectively. These findings demonstrate that the presence of extracellular matrix components prevents modulation of smooth muscle phenotype early in culture and suggests that the extracellular matrix synthesized and secreted by smooth muscle in the normal vessel wall contributes to the maintenance of their contractile functional state.
Towards Reducing Cognitive Load and Enhancing Usability through a Reduced Graphical User Interface for a Dynamic Geometry System: An Experimental Study (2012)

The interface is the main mechanism of communication between user and system features. In educational software, successful user interface designs minimize the cognitive load on users, thereby users can direct their efforts to maximize their understanding of the educational concepts being presented. We investigated whether a reduced interface make few cognitive demands on users in comparison to a complete interface. In this context, this research aims at analyzing a reduced and a complete interface of an interactive geometry software, and verify the educational benefits they provide. To this end, we designed the interfaces and carried out an experiment involving 69 undergraduate students. The experimental results indicate that an interface that hides advanced and extraneous features helps novice users to perform slightly better than novice users using a complete interface. After receiving proper training, however, a complete interface makes users more productive than a reduced interface.
Buckling interaction in regular arrays of distorted hexagonal plates (2003)

Abstract Linear elastic buckling strength assessments are presented for a range of thin plate arrays with optimal strength to weight ratio configurations subject to a range of arbitrary in-plane stress states. The outcomes of the assessment are presented as design curves demonstrating relative buckling strength increases with respect to the classical square plate datum of equal mass. A stiffness matrix method is adopted for the initial buckling strength predictions. The method is based on exact flat plate theory and assumes that the plate is continuous over supports, whereby deformations in one cell of the plate array influence the deformations in adjacent cells. The supporting webs of each cell are approximated in this study by simple rigid supports that enforce nodal lines or lines of zero out-of-plane displacement in the buckled panel, i.e. the bending and torsional stiffness provided by the supporting webs of the real structure are ignored. Selected results are validated by FEM prediction.
Regulation of Cathelicidin Gene Expression: Induction by Lipopolysaccharide, Interleukin-6, Retinoic Acid, and <i>Salmonella enterica</i> Serovar Typhimurium Infection (2000)

Cathelicidins are a family of antimicrobial peptides prominent in the host defense mechanisms of several mammalian species. In addition to their antimicrobial activities, these peptides have been implicated in wound healing, angiogenesis, and other innate immune mechanisms. To investigate the regulatory mechanisms of cathelicidin gene expression, we conducted in vitro experiments evaluating the bone marrow cell expression of two porcine cathelicidins, PR-39 and protegrin, and cloned and evaluated the promoter sequence of PR-39. In addition, we evaluated in vivo kinetics of cathelicidin gene expression in pigs during an infection with Salmonella enterica serovar Typhimurium. Lipopolysaccharide (LPS) increased PR-39 and protegrin mRNA expression, which was ameliorated by polymyxin B. Concentrations of PR-39 in supernatants from bone marrow cell cultures were increased 10-fold after LPS stimulation. Similarly, interleukin-6 (IL-6) and all-trans retinoic acid (RA) markedly induced cathelicidin gene expression. To verify the transcriptional activation of the PR-39 gene by these agents, we made a PR-39 promoter-luciferase construct containing the full-length PR-39 promoter driving luciferase gene expression and transiently transfected PK-15 epithelial cells. RA and IL-6 increased luciferase activity in PK-15 cells transfected with the PR-39 promoter-luciferase reporter. Similarly, Salmonella-challenged pigs showed increased expression of PR-39 and protegrin mRNA in bone marrow cells at 6 and 24 h postchallenge. Taken together, these findings show that bacterial products (LPS), IL-6, RA, and Salmonella infection enhance the expression of the cathelicidins, PR-39 and protegrin, in bone marrow progenitor cells, and we suggest that extrinsic modulation of this innate host defense mechanism may be possible.
Molecular beam epitaxy of layered Dy-Ba-Cu-O compounds (1988)

Heteroepitaxial Dy-Ba-Cu-O films have been grown in situ on SrTiO3 substrates using an oxygen plasma beam and elemental source beams in a modified molecular beam epitaxy machine. By periodically shuttering the Dy and Ba beams during growth, flat surfaces of layered Dy-Ba-Cu-O compounds have been obtained. Periodic oscillations in the intensity of the in situ reflection high-energy electron diffraction pattern were observed during shuttered growths. Depending on growth conditions, the as-grown layers have ranged from insulating to superconducting with onset temperatures above 60 K.