gebhart/patrepeval huggingface dataset:
State-of-the-art survey of multimode fiber optic wavelength division multiplexing (1983)

Optical wavelength division multiplexing (WDM) systems, with signals transmitted on different wavelengths through a single fiber, can have increased information capacity and fault isolation properties over single wavelength optical systems. This paper describes a typical WDM system. Also, a state-of-the-art survey of optical multimode components which could be used to implement the system is made. The components to be surveyed are sources, multiplexers, and detectors. Emphasis is given to the demultiplexer techniques which are the major developmental components in the WDM system.
Adsorption and Desorption of Indomethacin on Cellulose-like Biopolymers: Chitin and Chitosan. (1992)

The adsorption-desorption effect of cellulose-like biopolymers such as chitin and chitosan, and microcrystalline cellulose on indomethacin was investigated. The adsorptive capacity was ranked in the order: chitosan greater than chitin greater than microcrystalline cellulose. All the adsorption isotherms were found to follow Langmuir and Freundlich equations. However, chitosan-acetate gel powders and chitosan powders with pre-added acetic acid and methanol did not follow these equations, due to gel formations that led to more adsorption of indomethacin on the interlayer space of the gel. The strong adsorption of chitosan might result in difficult desorption of indomethacin.
Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase. (1994)

We have previously reported the existence of two different molecular species of protein methylase I (S-adenosylmethionine:protein-arginine N-methyltransferase, E.C. 2.1.1.23) in calf brain, one specific for myelin basic protein and the other for histone (Ghosh, S. K., Paik, W. K., and Kim, S. (1988) J. Biol. Chem. 263, 19024-19033). In the present study, however, we report that heterogeneous ribonucleoprotein particle protein A1 is most likely an in vivo substrate for the "histone-specific protein methylase I." The unmethylated recombinant protein A1 has been found to be a much superior methyl acceptor for the enzyme than histone with a Km value two orders of magnitude lower (0.19 microM) than that for histone (21 microM). Myelin basic protein, a specific inhibitor for histone protein methylase I, exhibited a lower IC50 for protein A1 methylation (IC50 = 33 microM) compared with histone methylation (IC50 = 220 microM) and competitively inhibited the former with a Ki value of 1.3 x 10(-6) M. The extent of inhibition of protein A1 and histone methylation by the polyclonal antibodies prepared against purified "histone protein methylase I" was identical. Maximally, 1.08-mol methyl groups were incorporated per mol of protein A1, which was 27-fold higher than that of histone (0.04 mol/mol of histone). HPLC analysis of the enzymatically methylated amino acid residues in protein A1 revealed the formation of NG-monomethylarginine and NG,NG-dimethylarginine. The ratio of NG,NG-dimethylarginine/NG-monomethylarginine increased as a function of incubation period; however, NG,N'G-dimethylarginine was not detectable. Proteolytic cleavage of the methyl-3H-labeled recombinant protein A1 by trypsin and Staphylococcus aureus V8 endoprotease indicated that protein A1 possesses multiple sites for methylation, one of which was identified as residue 194 arginine, which coincided with the in vivo methylation site.
Ephraim's Inorganic Chemistry. (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEphraim's Inorganic Chemistry.Therald MoelierCite this: J. Am. Chem. Soc. 1955, 77, 14, 3933Publication Date (Print):July 1, 1955Publication History Published online1 May 2002Published inissue 1 July 1955https://pubs.acs.org/doi/10.1021/ja01619a090https://doi.org/10.1021/ja01619a090research-articleACS PublicationsRequest reuse permissionsArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prevalence and Predictors of Overweight and Insulin Resistance in Offspring of Mothers With Gestational Diabetes Mellitus (2010)

Overweight and insulin resistance in children is increased in OGDM compared with OT1D or ONDM. The finding that overweight risk is associated mainly with maternal obesity suggests that familial predisposition contributes to childhood growth in these offspring.
JSMeter: comparing the behavior of JavaScript benchmarks with real web applications (2010)

JavaScript is widely used in web-based applications and is increasingly popular with developers. So-called browser wars in recent years have focused on JavaScript performance, specifically claiming comparative results based on benchmark suites such as SunSpider and V8. In this paper we evaluate the behavior of JavaScript web applications from commercial web sites and compare this behavior with the benchmarks. We measure two specific areas of JavaScript runtime behavior: 1) functions and code and 2) events and handlers. We find that the benchmarks are not representative of many real web sites and that conclusions reached from measuring the benchmarks may be misleading. Specific common behaviors of real web sites that are underemphasized in the benchmarks include event-driven execution, instruction mix similarity, cold-code dominance, and the prevalence of short functions. We hope our results will convince the JavaScript community to develop and adopt benchmarks that are more representative of real web applications. 1
Mechanism of Off-Target Interactions and Toxicity of Tamoxifen and Its Metabolites (2017)

Tamoxifen is an estrogen modulator that acts to competitively inhibit the binding of endogenous estrogens. It is widely used for treatment of breast cancer; however, analogous with many antineoplastic agents, tamoxifen is associated with numerous adverse effects, most prominently nausea. We have identified several off-target receptors of tamoxifen and 22 of its metabolites that include histamine H1 and H3, and muscarinic M1, M4, and M5 subtypes, and dopamine D2 receptor. We have shown how they are associated with tamoxifen and its metabolites' toxicity through a comprehensive computational analysis of their interaction modes, which were also compared to that of the related endogenous substrates of each receptor. The results were further evaluated using available in vivo and in vitro data. The presented work provides foundational knowledge toward the determination of the precise mechanism of nausea induction, and in particular, interactions of tamoxifen and its metabolites with the receptors involved in that biomolecular pathway. This study can assist in predicting the potential undesired effects of the chemicals with common pharmacophores or similar fragments to that of tamoxifen and its metabolites and serve drug discovery research in developing more effective and tolerable tamoxifen analogues or chemotherapeutic agents.
Issues with lip sync animation: can you read my lips? (2003)

Lip-sync animation is complex and challenging. It promises to be important in natural human-computer interfaces and entertainment as well as aid in the education of the deaf. It is an important component in creating a realistic human figure. Speech is based on principles from anatomy, physics, and psychophysiology. We discuss some of the issues that make speech so complex to model visually.
Total Synthesis of (−)- and (+)-Lentiginosine (2002)

Total synthesis of (-)-lentiginosine was achieved from D-mannitol using highly stereoselective reactions. Similarly, (+)-lentiginosine was synthesized from L-tartaric acid.
Industrial production of multiwalled carbon nanotubes (2007)

Abstract Carbon Nanotubes are currently being synthesized by different methods. The methods differ largely by the achievable space‐time yield, amorphous carbon content and carbon purity. High space‐time yields can only be achieved by CVD processes. Though usually low contents of amorphous carbon are observed in CVD processes, C‐purity is generally decreased due to catalyst residues. Bayer Technology Services has developed a high‐yield process for multi‐walled carbon nanotubes (MWNT, trade name Baytubes ® ) based on a CCVD process starting from light hydrocarbons. The produced Baytubes ® are characterized by a very high graphite content and an excellent purity (carbon content >95 wt%). Due to their high purity and quality, Baytubes ® can be employed directly in further processing. The Baytubes ® were incorporated into different polymers and also into liquids. The primary feature for good mechanical and electrical properties of the polymer composites is a full dispersion of the CNT in the polymer matrix. TEM analysis is an important method to investigate the CNT dispersion on the nanometer scale. But it is also necessary to combine different methods to ensure a good and constant dispersion quality. Thus, different analysis methods were developed by BTS during product development. Process scale‐up is under way and a nominal production capacity of 60 tons per year has already been commissioned. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
An enzyme-linked immunosorbent assay for lactose synthase (galactosyltransferase) in serum and its application as a tumor marker in ovarian carcinoma. (1983)

This assay for lactose synthase (galactosyltransferase, EC 2.4.1.22) in serum involves two sequential incubations: serially diluted standard or sample antigen is reacted with a fixed amount of antibody; unbound antibody is then adsorbed to wells of antigen-coated microtiter plates and determined by a second antibody directed against the first antibody and coupled to phosphatase. The standard curve is linear for galactosyltransferase concentrations of 10 to 600 micrograms/L. The within-assay CV of a serum sample was 9.3% (SD 4.1%), the between-assay was 3.8% (SD 2.4%). Serum galactosyltransferase concentrations computed from three different dilutions yielded CVs of 6.5% (SD 5.7%, n = 14). We evaluated the method's accuracy by recovery analysis and by comparing enzyme activity in serum with that of purified galactosyltransferase from human milk. The normal reference interval, as estimated from data on 27 healthy blood donors, was 60-436 micrograms/L (mean 224, SD 101 micrograms/L). We applied the assay to samples of serum from ovarian carcinoma patients grouped according to tumor burden. We also determined galactosyltransferase in ascites fluid and found these values useful for diagnosis, whereas determinations in serum may serve mainly for patient monitoring.
Selective photocatalytic oxidation of 4-substituted aromatic alcohols in water with rutile TiO2 prepared at room temperature (2009)

Home-prepared (HP) rutile TiO2catalysts were prepared at room temperature by using H2O and TiCl4 in different ratios and without addition of additives. The catalysts were used for carrying out the selective photocatalytic oxidation of 4-methoxybenzyl alcohol to 4-methoxybenzaldehyde in aqueous suspension, free from any organic co-solvent. The selectivities showed by the home prepared catalysts were in the 45–74% range, up to four times higher than that of a commercial rutile TiO2 sample, the reaction rates being comparable. By using the most selective photocatalyst, the oxidation of benzyl, 4-methylbenzyl, and 4-nitrobenzyl alcohols was also carried out in order to investigate the influence of the substituent group on the oxidation rate and selectivity. The presence of an –OCH3group positively influenced the selectivity whereas a –NO2group showed to have a detrimental effect. The Hammett relationship effectively describes the influence of substituent group on the kinetic constant of partial oxidation of aromatic alcohols to aldehydes.
<title>Performance of the optical wavelet matched filter</title> (1993)

Optical wavelet matched filter performs the wavelet transforms for edge enhancement and correlations between the wavelet transform coefficients in a single step for shift invariant pattern recognition. The performance of the wavelet matched filter depends on the scale factor s. A systematic study and comparison on the light efficiency, discrimination capability and robustness to noise is made for the wavelet matched filter, the matched spatial filter and the phase-only matched filter.
Acute gastroenteritis in children (2007)

Rotavirus is the most common cause of acute gastro enteritis worldwide and vaccination will have a major impact on disease rates, morbidity, and mortality Most children are not dehydrated and can be managed at home Dehydration, metabolic acidosis, and electrolyte disturbance can be prevented and treated by fluid therapy Most children with mildmoderate dehydration can be treated with oral or enteral rehydration using low osmolality oral rehydration solutions Severely dehydrated or shocked children usually need intravenous fluids and hospital admission Drugs are usually unnecessary and may do harm General practitioners have an important role in prevention, through encouraging breastfeeding, recommending and advocating free access to rotavirus vaccination, and educating carers about personal and food hygiene
Gibberellin Modulates Anther Development in Rice via the Transcriptional Regulation of GAMYB (2009)

Gibberellins (GAs) play important roles in regulating reproductive development, especially anther development. Our previous studies revealed that the MYB transcriptional factor GAMYB, an important component of GA signaling in cereal aleurone cells, is also important for anther development. Here, we examined the physiological functions of GA during anther development through phenotypic analyses of rice (Oryza sativa) GA-deficient, GA-insensitive, and gamyb mutants. The mutants exhibited common defects in programmed cell death (PCD) of tapetal cells and formation of exine and Ubisch bodies. Microarray analysis using anther RNAs of these mutants revealed that rice GAMYB is involved in almost all instances of GA-regulated gene expression in anthers. Among the GA-regulated genes, we focused on two lipid metabolic genes, a cytochrome P450 hydroxylase CYP703A3 and beta-ketoacyl reductase, both of which might be involved in providing a substrate for exine and Ubisch body. GAMYB specifically interacted with GAMYB binding motifs in the promoter regions in vitro, and mutation of these motifs in promoter-beta-glucuronidase (GUS) transformants caused reduced GUS expression in anthers. Furthermore, a knockout mutant for CYP703A3 showed gamyb-like defects in exine and Ubisch body formation. Together, these results suggest that GA regulates exine formation and the PCD of tapetal cells and that direct activation of CYP703A3 by GAMYB is key to exine formation.
Designing carbonic anhydrase inhibitors for the treatment of breast cancer (2015)

The most advanced CA IX inhibitors candidates, which demonstrate antimetastatic activity in breast cancer, are the sulfonamides, with one compound (SLC-0111) currently in Phase I clinical development. The fact that this first inhibitor has progressed could increase interest in the development of conceptually novel antitumor/antimetastic drugs belonging to the CA inhibitors class.
Optical measurements of particle size and concentration in densely laden media using a visible/infrared double extinction technique (1987)

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Asymptotic analysis of stochastic gradient-based adaptive filtering algorithms with general cost functions (1996)

This paper presents an analysis of stochastic gradient-based adaptive algorithms with general cost functions. The analysis holds under mild assumptions on the inputs and the cost function. The method of analysis is based on an asymptotic analysis of fixed stepsize adaptive algorithms and gives almost sure results regarding the behavior of the parameter estimates, whereas previous stochastic analyses typically considered mean and mean square behavior. The parameter estimates are shown to enter a small neighborhood about the optimum value and remain there for a finite length of time. Furthermore, almost sure exponential bounds are given for the rate of convergence of the parameter estimates. The asymptotic distribution of the parameter estimates is shown to be Gaussian with mean equal to the optimum value and covariance matrix that depends on the input statistics. Specific adaptive algorithms that fall under the framework of this paper are signed error least mean square (LMS), dual sign LMS, quantized state LMS, least mean fourth, dead zone algorithms, momentum algorithms, and leaky LMS.
Formation of pn Homojunction in Cu(InGa)Se<sub>2</sub> Thin Film Solar Cells by Zn Doping (2000)

In this study, a pn homojunction was intentionally fabricated in the Cu(InGa)Se 2 (CIGS) layer by Zn doping. For Zn doping of the CIGS layer, Zn was evaporated after CIGS formation, and a potential improvement in cell performance was confirmed by this technique. Furthermore, Zn diffusion into the CIGS film was investigated by secondary ion mass spectroscopy (SIMS). A conductivity-type conversion from p-type to n-type was studied by the measurement of the cross-sectional electron beam-induced current (junction EBIC: JEBIC) and the spectral response of solar cells. A conversion efficiency of 11.5% has been achieved using the Zn-doped CIGS layer without a buffer layer and by the formation of a pn homojunction in the CIGS absorber.
Distribution of S‐layers on the surface of <i>Bacillus cereus</i> strains: phylogenetic origin and ecological pressure (2001)

Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis have been described as members of the Bacillus cereus group but are, in fact, one species. B. anthracis is a mammal pathogen, B. thuringiensis an entomopathogen and B. cereus a ubiquitous soil bacterium and an occasional human pathogen. In two clinical isolates of B. cereus, in some B. thuringiensis strains and in B. anthracis, an S-layer has been described. We investigated how the S-layer is distributed in B. cereus, and whether phylogeny or ecology could explain its presence on the surface of some but not all strains. We first developed a simple biochemical assay to test for the presence of the S-layer. We then used the assay with 51 strains of known genetic relationship: 26 genetically diverse B. cereus and 25 non-B. anthracis of the B. anthracis cluster. When present, the genetic organization of the S-layer locus was analysed further. It was identical in B. cereus and B. anthracis. Nineteen strains harboured an S-layer, 16 of which belonged to the B. anthracis cluster. All 19 were B. cereus clinical isolates or B. thuringiensis, except for one soil and one dairy strain. These findings suggest a common phylogenetic origin for the S-layer at the surface of B. cereus strains and, presumably, ecological pressure on its maintenance.
Evaluation of a new composite prosthesis (PL‐PU99) for the repair of abdominal wall defects in terms of behavior at the peritoneal interface (2002)

This study was designed to evaluate the behavior of a new composite polypropylene-polyurethane (PL-PU99) when placed in direct contact with the visceral peritoneum during the repair of an abdominal wall defect. Full-thickness abdominal wall defects (7 x 5 cm) were created in 36 anaesthetized white New Zealand rabbits. The defects were repaired with polypropylene prostheses or PL-PU99 prostheses (comprised of PL and a polyurethane sheet glued to the PL with acrylic adhesive) to establish two study groups (n = 18 each). Animals were sacrified 14, 30, or 90 days after implantation and prosthesis/surrounding tissue specimens were subjected to light and electron microscopy and morphometric analysis of the newly formed peritoneum. Immunohistochemical analysis was performed using the rabbit specific monoclonal antibody RAM-11. The biomechanical strength of the implants was also assessed. Firm adhesions were detected in the PL implants, whereas adhesions were practically non-existent in the PL-PU99 implants. The surface area covered by adhesions was greater (p < 0.01) in the PL group (7.36 vs. 0.11 cm2). The neoperitoneum formed after the implantation of a PL prosthesis was disorganized in structure, whereas that formed at the interface with the PL-PU99 prosthesis was structurally similar to the host peritoneum. The excellent performance of the PL-PU99 prosthesis shown in this study warrants further investigation into its use for the repair of abdominal wall defects when the prosthetic patch needs to be placed in contact with the intestinal loops.
CFD-Aided Development of Spray for an Outwardly Opening Direct Injection Gasoline Injector (1998)

<div class="htmlview paragraph">A high pressure outwardly opening fuel injector has been developed to produce sprays that meet the stringent requirements of gasoline direct injection (DI) combustion systems. Predictions of spray characteristics have been made using KIVA-3 in conjunction with Star-CD injector flow modeling. After some modeling iterations, the nozzle design has been optimized for the required flow, injector performance, and spray characteristics. The hardware test results of flow and spray have confirmed the numerical modeling accuracy and the spray quality.</div> <div class="htmlview paragraph">The spray's average Sauter mean diameter (SMD) is less than 15 microns at 30 mm distance from the nozzle. The DV90, defined as the drop diameter such that 90% of the total liquid volume is in drops of smaller diameter, is less than 40 microns. The maximum penetration is about 70 mm into air at atmospheric pressure. An initial spray slug is not created due to the absence of a sac volume.</div>
The<i>microphthalmia</i>transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter (2002)

The microphthalmia transcription factor (MITF) regulates different target genes in several distinct cell types, including osteoclasts. The role of the closely related factors TFE3 and TFEC in MITF action was studied. The TFE3 and TFEC proteins were expressed in osteoclast-like cells, and both could be immunoprecipitated in a complex with MITF. In transient transfection assays, TFE3 and TFEC could collaborate with MITF to superactivate the tartrate resistant acid phosphatase (TRAP) promoter, a target for MITF in osteoclasts. Although TFEC had been thought to act as a repressor, we could demonstrate that TFEC acted as a transactivator when fused to the gal4 DNA-binding domain in a yeast one-hybrid-type assay. Additionally, two mRNA isoforms of MITF, MITF-M and MITF-A, were detected in primary osteoclast-like cells by RT-PCR. In transient transfection assays, the MITF-A and MITF-M isoforms activated the promoter of the TRAP gene to the same extent, and both forms could collaborate equally well with TFE3 to activate the TRAP promoter. These results indicate that although different isoforms of MITF appear to be functionally similar, the TFE3 and TFEC proteins may collaborate with MITF to efficiently regulate expression of target genes in osteoclasts.