gebhart/patrepeval huggingface dataset:
An interactive fuzzy satisficing method for multiobjective nonconvex programming problems with fuzzy numbers through coevolutionary genetic algorithms (2001)

In this paper, by considering the experts' fuzzy understanding of the nature of the parameters in the problem-formulation process, multiobjective nonconvex nonlinear programming problems with fuzzy numbers are formulated and an interactive fuzzy satisficing method through coevolutionary genetic algorithms is presented. Using the alpha-level sets of fuzzy numbers, the corresponding nonfuzzy alpha-programming problem is introduced. After determining the fuzzy goals of the decision maker, if the decision maker specifies the degree alpha and the reference membership values, the corresponding extended Pareto optimal solution can be obtained by solving the augmented minimax problems for which the coevolutionary genetic algorithm, called GENOCOP III, is applicable. In order to overcome the drawbacks of GENOCOP III, the revised GENOCOP III is proposed by introducing a method for generating an initial feasible point and a bisection method for generating a new feasible point efficiently. Then an interactive fuzzy satisficing method for deriving a satisficing solution for the decision maker efficiently from an extended Pareto optimal solution set is presented together with an illustrative numerical example.
Parallel active/passive force control of industrial robots with joint compliance (2014)

Active force control of an industrial robot with an end-effector force/torque sensor effectively handles compliant industrial tasks like assembly operations, surface finishing jobs, cooperative manipulation, etc. However, the robot still remains intrinsically unsafe for dynamically changing environment where the chances of the links coming in contact with the environment exists. This paper proposes a scheme for active force control at the end-effector using a six-component force/torque sensor through external force-control loop along with steady-state error compensator. In parallel, passive joint compliance was achieved by limiting the currents to joint motors based on an identified model of the robot under study. The proposed method was implemented on a KUKA KR5 ARC industrial robot and tested for passive compliance by colliding with another moving robot in its workspace. Active force control was tested to maintain a desired force on contact to demonstrate the effectiveness of the controller.
Factors Affecting the Balance Between Teaching and Research in the Universities of the Twenty‐First Century (1997)

The author suggests that the current mode of knowledge production at the leading edges of advanced studies in the sciences, the social sciences, and the humanities is changing dramatically. This development, that is being driven as much by the internal dynamics of knowledge production as by government policy and by the demand for competitiveness, has profound implications for the balance of teaching and research in universities. A traditional, university‐based mode of knowledge production, characterized by a linear model, that the author calls Mode 1, is being complemented and to some extent supplanted by a new type of knowledge production called Mode 2 that is characterized by knowledge produced in the context of application, transdisciplinarity, heterogeneity and organizational diversity, enhanced social accountability, and broadly based systems of quality control. Mode 2 knowledge production questions the validity of the linear model of knowledge production characteristic of Mode 1. Mode 2 requires the universities, particularly in regard to research, to come to grips with a new pattern for the social distribution of knowledge production, especially the fact that they are no longer either the sole or even the primary institutions on the cognitive landscape.
Sleeved Bending Actuators for Soft Grippers: A Durable Solution for High Force-to-Weight Applications (2018)

Soft grippers are known for their ability to interact with objects that are fragile, soft or of an unknown shape, as well as humans in collaborative robotics applications. However, state-of-the-art soft grippers lack either payload capacity or durability, which limits their use in industrial applications. In fact, high force density pneumatic soft grippers require high strain and operating pressure, both of which impair their durability. This work presents a new sleeved bending actuator for soft grippers that is capable of high force density and durability. The proposed actuator is based on design principles previously proven to improve the life of pneumatic artificial muscles, where a sleeve provides a uniform reinforcement that reduces local stresses and strains in the inflated membrane. The sleeved bending actuator features a silicone membrane and an external two-material sleeve that can support high pressures while providing a flexible grip. The proposed sleeved bending actuators are validated through two grippers, sized according to foreseen soft gripper applications: A small gripper for drone perching and lightweight food manipulation, and a larger one for the manipulation of heavy material (>5 kg) of various weights and sizes. Performance assessment shows that these grippers have payloads up to 5.2 kg and 20 kg, respectively. Durability testing of the grippers demonstrates that the grippers have an expected lifetime ranging from 263,000 cycles to more than 700,000 cycles. The grippers are tested in various settings, including the integration of a gripper into a Phantom 2 quadcopter, a perching demonstration, as well as the gripping of light and heavy food items. Experiments show that sleeved bending actuators constitute a promising avenue for durable and strong soft grippers.
Reduction of Common-Mode Conducted Noise Emissions in PWM Inverter-fed AC Motor Drive Systems using Optimized Passive EMI Filter (2010)

Conducted electromagnetic interference (EMI) generated by PWM inverter‐fed induction motor drive systems, which are currently widely used in many industrial and/or avionic applications, causes severe parasitic current problems, especially at high frequencies (HF). These restrict power electronic drive’s evolution. In order to reduce or minimize these EMI problems, several techniques can be applied. In this paper, insertion of an optimized passive EMI filter is proposed. This filter is optimized by taking into account real impedances of each part of a considered AC motor drive system contrarily to commercial EMI filters designed by considering internal impedance of disturbance source and load, equal to 50Ω. Employing the latter EMI filter would make EMI minimization less effective. The proposed EMI filter optimization is mainly dedicated to minimize common mode (CM) currents due to its most dominant effects in this kind of system. The efficiency of the proposed optimization method using two‐port network approach is deduced by comparing the minimized CM current spectra to an applied normative level (ex. DO‐160D in aeronautics).
Nontoxic Chemical Interdiction of the Epithelial-to-Mesenchymal Transition by Targeting Cap-Dependent Translation (2009)

Normal growth and development depends upon high fidelity regulation of cap-dependent translation initiation, a process that is usurped and redirected in cancer to mediate acquisition of malignant properties. The epithelial-to-mesenchymal transition (EMT) is a key translationally regulated step in the development of epithelial cancers and pathological tissue fibrosis. To date, no compounds targeting EMT have been developed. Here we report the synthesis of a novel class of histidine triad nucleotide binding protein (HINT)-dependent pronucleotides that interdict EMT by negatively regulating the association of eIF4E with the mRNA cap. Compound eIF4E inhibitor-1 potently inhibited cap-dependent translation in a dose-dependent manner in zebrafish embryos without causing developmental abnormalities and prevented eIF4E from triggering EMT in zebrafish ectoderm explants without toxicity. Metabolism studies with whole cell lysates demonstrated that the prodrug was rapidly converted into 7-BnGMP. Thus we have successfully developed the first nontoxic small molecule able to inhibit EMT, a key process in the development of epithelial cancer and tissue fibrosis, by targeting the interaction of eIF4E with the mRNA cap and demonstrated the tractability of zebrafish as a model organism for studying agents that modulate EMT. Our work provides strong motivation for the continued development of compounds designed to normalize cap-dependent translation as novel chemo-preventive agents and therapeutics for cancer and fibrosis.
Evaluation of RNA Interference in Developing Porcine Granulosa Cells Using Fluorescence Reporter Genes (2004)

Gene silencing using small interfering RNA (siRNA) may be useful for functional analyses of unidentified genes expressed during cell differentiation. The present study was performed to evaluate RNA interference (RNAi) in porcine granulosa cells stimulated with bovine FSH, by using two fluorescence reporter genes: a plasmid encoding green fluorescent protein (GFP) and a plasmid encoding red fluorescent protein (RFP). The siRNA targeting GFP mRNA sequence (GFP-siRNA) with both plasmids was introduced into cultured cells by lipofection. GFP- and RFP-expressing cells were observed under fluorescence microscopy and analyzed by flow cytometry. Strong fluorescence was observed after introduction of both plasmids into cells. The intensity of green fluorescence generated by GFP was greatly suppressed by introduction of GFP-siRNA, showing an approximate 70% decrease in the ratio of green to red fluorescence. Consequently, we concluded that gene silencing by siRNA can be used to analyze the functions of genes of interest during differentiation of porcine granulosa cells.
Splog Detection using Content, Time and Link Structures (2007)

This paper focuses on spam blog (splog) detection. Blogs are highly popular, new media social communication mechanisms and splogs corrupt blog search results as well as waste network resources. In our approach we exploit unique blog temporal dynamics to detect splogs. The key idea is that splogs exhibit high temporal regularity in content and post time, as well as consistent linking patterns. Temporal content regularity is detected using a novel autocorrelation of post content. Temporal structural regularity is determined using the entropy of the post time difference distribution, while the link regularity is computed using a HITS based hub score measure. Experiments based on the annotated ground truth on real world dataset show excellent results on splog detection tasks with 90% accuracy.
Cyclooligomeric phenol-aldehyde condensation products. 2. Stereoselective synthesis and DNMR study of two 1,8,15,22-tetraphenyl[14]metacyclophan-3,5,10,12,17,19,24,26-octols (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclooligomeric phenol-aldehyde condensation products. 2. Stereoselective synthesis and DNMR study of two 1,8,15,22-tetraphenyl[14]metacyclophan-3,5,10,12,17,19,24,26-octolsA. G. Sverker HoegbergCite this: J. Am. Chem. Soc. 1980, 102, 19, 6046–6050Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/ja00539a012https://doi.org/10.1021/ja00539a012research-articleACS PublicationsRequest reuse permissionsArticle Views1994Altmetric-Citations266LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CONMan (2007)

Networks are hard to manage and in spite of all the so called holistic management packages, things are getting worse. We argue that the difficulty of network management can partly be attributed to a fundamental flaw in the existing architecture: protocols expose all their internal details and hence, the complexity of the ever-evolving data plane encumbers the management plane. Guided by this observation, in this paper we explore an alternative approach and propose Complexity Oblivious Network Management (CONMan), a network architecture in which the management interface of data-plane protocols includes minimal protocol-specific information. This restricts the operational complexity of protocols to their implementation and allows the management plane to achieve high level policies in a structured fashion. We built the CONMan interface of a few protocols and a management tool that can achieve high-level configuration goals based on this interface. Our preliminary experience with applying this tool to real world VPN configuration indicates the architecture's potential to alleviate the difficulty of configuration management.
Dual-polarized bidirectional rod antenna for diversity reception at street microcell base stations (2002)

This paper proposes the DP-BIRA (dual-polarized bidirectional rod antenna) which has the optimum antenna beam shape for street microcells and minimizes degradation in the received signal power caused by the polarization mismatch at the street microcell base stations. The theoretical results given by the multi-ray model are verified; the optimum antenna configuration for the street microcell base station is a bidirectional rod antenna (BIRA) composed of radiating elements arrayed in the E-plane (vertical). When the inclination angle of the handy-phone antenna is 90 degrees, the signal power of the height diversity collinear antenna (HCA), which is commonly used for diversity reception at the PHS base stations, degrades up to about -15 dB, and the HCA cell length is reduced by almost half from that of the vertically-polarized incident wave. On the other hand, the DP-BIRA holds the received signal power almost constant against inclination, so almost the same cell length is realized regardless of the handy-phone inclination. A DP-BIRA is fabricated and tested in a street cell environment in an urban area to verify the validity of our design method and the usefulness of the DP-BIRA.
The Degradation Front Model- A Tool for the Chemical Study of the Degradation of Epoxy Resins in Fire (1996)

This work studies two different epoxy resin systems using cone calorimeter data and the results of classical thermogravimetric analyses. It presents a discussion of the chemical behavior of the resins using cone calorimeter results (mainly the rate of heat release). The thermogravimetric analyses give the invariant kinetic parameters (IKP) and a computation of the distribution of probabilities associated with the kinetic functions which allow a kinetic representation of the resins' degradations. Then, the study using the cone calorimeter allows to obtain kinetic data under the conditions of a fire and to compute the temperature of the degradation front (zone where the weight loss occurs). Comparison of the values of this temperature and of the tempera ture measured in the lowest volume of the sample allows the comparison of the protective character of the carbon-based shields which form in the first step of the resins' degradation.
Particle tracking velocimetry of the flow field around a collapsing cavitation bubble (2009)

The velocity field in the vicinity of a laser-generated cavitation bubble in water is investigated by means of particle tracking velocimetry (PTV). Two situations are explored: a bubble collapsing spherically and a bubble collapsing aspherically near a rigid wall. In the first case, the accuracy of the PTV method is assessed by comparing the experimental data with the flow field around the bubble as obtained from numerical simulations of the radial bubble dynamics. The numerical results are matched to the experimental radius–time curve extracted from high-speed photographs by tuning the model parameters. Trajectories of tracer particles are calculated and used to model the experimental process of the PTV measurement. For the second case of a bubble collapsing near a rigid wall, both the bubble shape and the velocity distribution in the fluid around the bubble are measured for different standoff parameters γ at several instants in time. The results for γ > 1 are compared with the corresponding results of a boundary-integral simulation. For both cases, good agreement between simulation and experiment is found.
Malignant Glioma: MR Imaging by Using 5-Aminolevulinic Acid in an Animal Model (2014)

Administration of 5-ALA increased the intracellular iron concentration of glioblastomas by promoting the synthesis of heme, which is the metabolite of 5-ALA. Because intracellular iron can be detected at MR imaging, 5-ALA may aid in the identification of high-grade foci in gliomas.
Isolation, Culture, and Characterization of Human Intestinal Smooth Muscle Cells (2003)

In vitro models utilizing human mesenchymal cells isolated from normal and pathological tissue have proven very useful for studies of wound repair and fibrosis. We have been studying the pathogenesis of intestinal fibrosis and, over the course of 20 yr, have refined techniques for the isolation, culture, and characterization of smooth muscle cells of the human intestinal muscularis propria (1). These methodologies have been adapted for isolation of similar cell types from liver, gallbladder, and blood vessels (2). In this chapter, we describe techniques for the isolation and culture of these cells (procedure A), for the quantitation of procollagen secretion (procedure B), and for the screening of isolates for the expression of smooth muscle-specific cytoskeletal proteins (procedure C).
Microreactor Technology and Continuous Processes in the Fine Chemical and Pharmaceutical Industry: Is the Revolution Underway? (2008)

Microreactors have shown their ability to improve chemical processes and routes; however, their integration into chemical production processes depends not only on technical advances. Cost issues and productions logistics play a crucial role, too, and are highlighted with two different case studies. Economical drivers for the pharmaceutical industry are described with emphasis on future development of microprocess engineering.
Preferential DNA repair of alkali-labile sites within the active insulin gene. (1990)

DNA damage and repair were studied in a DNA fragment containing the insulin gene after treatment of cells with methylnitrosourea. For these studies, two clonal isolates from the same rat insulinoma cell line which differ in that the insulin gene is transcribed in one (RINr 38) and is silent in the other (RINr B2) were utilized. Both the determination of immunologically reactive insulin released and the expression of insulin mRNA were used to verify that the gene was transcribed in the RINr 38 cells and not in the RINr B2 cells. Repair kinetics for the removal of alkali-labile sites were comparable across the entire genome in the RINr 38 and RINr B2 cells as determined using alkaline sucrose gradient sedimentation and a 32P end-labeling assay for the quantitation of N7-methylguanine. Quantitative DNA blot analysis was utilized to assess the formation and repair of alkali-labile sites within the restriction fragment containing the insulin gene. Alkali-labile sites appeared to be formed equally within the restriction fragment containing the insulin gene in both the RINr 38 and RINr B2 cells. However, at 24 h, 60% of the lesions were removed from the fragment in the RINr 38 cells, where the gene was transcribed, compared to the removal of only 20% in the RINr B2 cells, where the gene was silent. Thus, it appears that alkali-labile sites induced by exposure to methylnitrosourea are repaired more efficiently in the DNA fragment containing the insulin gene when it is actively transcribed.
Cobalt nitride films produced by reactive pulsed laser deposition (2006)

The nitrides of magnetic metal are becoming important due to their potential technological applications. In this work cobalt nitride thin films are deposited by reactive pulsed laser deposition (nitrogen environments) on silicon substrates at room temperature. The resultant films are characterized in-situ by Auger, X-Ray Photoelectron and Electron Energy Loss Spectroscopies. The chemical bond of the CoNx is strongly linked to the stoichiometry, and it can be controlled by the N background pressure. We conclude that this deposition method offers a means for fine-tuning the properties of cobalt nitride
The small cage 12,17-dimethyl-5-oxa-1,9,12,17-tetra-azabicyclo[7.5.5]nonadecane (L): its synthesis, characterization, and ‘proton sponge’ behaviour. The crystal structure of the dipicrate salt [H<sub>2</sub>(L)](picrate)<sub>2</sub> (1989)

The synthesis and characterization of the new oxa-azamacrobicycloalkane 12,17-dimethyl-5-oxa-1,9,12,17-tetra-azabicyclo[7.5.5]nonadecane (L) are described. Its basicity behaviour in both aqueous and water–Me2SO (50:50 mol/mol) solutions has been investigated by potentiometric and spectroscopic (1H and 13C n.m.r.) techniques. In aqueous solution it behaves as a very strong base (proton sponge) in the first protonation step, and as a relatively strong base in the second step (log k2= 11.21). In the mixed water–Me2SO solvent both protonation constants have been measured: log k1= 14.0 and log k2= 8.2. 1H N.m.r. experiments indicate that in the monoprotonated species H(L)+ the proton is rapidly exchanged with acidic hydrogens on the n.m.r. timescale. 1H–1H and 1H–13C two-dimensional n.m.r. experiments allowed the unequivocal assignment for all the 1H proton and 13C resonances of both species H(L)+ and H2(L)2+. Crystals of [H2(L)](picrate)2 are monoclinic, space group P21/n, with a= 12.868(8), b= 17.201(2), c= 16.614(2)Å, β= 110.18(1)°, and Z= 4; final R values of 0.090 (Rw= 0.090) for 3 801 observed reflections. The four basal nitrogen atoms and the apical oxygen atom are located at the apices of a slightly distorted square pyramid. X-Ray analysis shows that protonation occurs on the NCH3, groups. Each hydrogen atom of the NH+CH3 interacts with the oxygen atom, the 0 ⋯ H distances 2.328(16) and 2.112(18)Å, and with both bridgehead nitrogen atoms, the H ⋯ N distances ranging from 2.32 to 2.34 Å. This arrangement makes the overall structure very stable from the thermodynamic point of view and explains the unusually high basicity of (L) in both first- and second-protonation step.
Complex Formation in the Reaction C+(D2,D)CD+ (1971)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation C. R. Iden, R. Liardon, W. S. Koski; Complex Formation in the Reaction C+(D2,D)CD+. J. Chem. Phys. 15 March 1971; 54 (6): 2757–2758. https://doi.org/10.1063/1.1675242 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search