gebhart/patrepeval huggingface dataset:
Geomorphic evidence for Plio-Quaternary compression in the Andean foothills of the southern Neuquén Basin, Argentina (2010)

[1] The southern central Andes foothills are made of imbricate thick- and thin-skinned fold and thrust belts. They were formed during Cretaceous and Miocene compressive periods by successive eastward propagation episodes of the orogenic front. We analyze remnant terraces and alluvial deposits of the Neuquén River and its tributaries to study the Plio-Quaternary tectonic regime in the southern Neuquén Basin. Topographic profiles of remnant terraces show a crustal-scale (tens of kilometers) anomaly above the Chihuido South anticline. This anomaly is accompanied by sedimentary aggradations downstream and upstream of the anticline. Another anomaly in the terrace profiles, correlated with a knickpoint in the current Neuquén River, is observed farther east, near Añelo. We interpret these anomalies to be the consequence of a Plio-Quaternary uplift of the Chihuidos and Añelo anticlines. Folding and surface faulting of Plio-Quaternary alluvial deposits show that this uplift is concomitant with the reactivation of the Miocene orogenic front and of the predominantly thin-skinned Agrio fold-and-thrust belt. From these data we infer that the southern Neuquén Basin is still shortening under a compressive stress regime and that the Andean orogenic front is migrating farther to the east. Extensional features in the study area correspond mainly to thin-skinned gravitational gliding, resulting from crustal uplift. Thus, we argue that the tectonic compressive regime is preserved in the southern Neuquén Basin throughout the Plio-Quaternary, though the slab may have steepened during this period.
Highly Conserved Regions of the Immunodominant Major Surface Protein 2 of the Genogroup II Ehrlichial Pathogen <i>Anaplasma marginale</i> Are Rich in Naturally Derived CD4+ T Lymphocyte Epitopes that Elicit Strong Recall Responses (2001)

Genogroup II ehrlichia, including the agent of human granulocytic ehrlichiosis, Ehrlichia phagocytophila, and the bovine pathogen Anaplasma marginale, express a markedly immunodominant outer membrane protein designated major surface protein 2 (MSP2). MSP2 is encoded by a multigene family, resulting in the expression of variant B cell epitopes. MSP2 variants are sequentially expressed in the repeated cycles of rickettsemia that characterize persistent A. marginale infection and control of each rickettsemic cycle is associated with development of a variant-specific IgG response. Importantly, these persistent rickettsemic cycles are controlled at levels 100-1000 times lower than those responsible for clinical disease during acute infection. Control of rickettsemia during persistence could result from an anamnestic Th lymphocyte response to conserved regions of MSP2 that enhances the primary Ab response against newly emergent variants. Comparison of MSP2 variants reveals conserved N and C termini flanking the central, surface-exposed hypervariable region that represents the variant B lymphocyte epitopes. We demonstrate MSP2-specific CD4(+) T lymphocyte recognition of epitopes common to several strains of A. marginale and the related pathogen A. ovis. Furthermore, T lymphocyte lines from three individuals identified six to nine overlapping peptides representing a minimum of four to seven dominant or subdominant epitopes in these conserved N and C termini. Immunodominant peptides induced high levels of IFN-gamma, a cytokine associated with protection against ehrlichia and needed for rapid generation of variant-specific IgG2. The presented data support the potential importance of a strong Th lymphocyte response to invariant MSP2 epitopes in controlling rickettsemia during persistent infection to subclinical levels.
The Performance of Adults of Various Grade Levels in Specific Mental Functions (1939)

The data for the present study were obtained from a test used in con nection with the educational program in a Civilian Conservation Corps Camp. In a camp of some two hundred young men it was found that a wide range of educational background was represented. A small percent of enrollees had only a fourth-grade education, others a fifth, and so on up the scale to high-school and college levels. Answers to the following questions were sought : 1. Is there an increase in performance with increase in grade level? For example, is the young man who completed the tenth grade any more capable in arithmetic and vocabulary than one who fin ished only the eighth grade ? 2. If there is an increase in performance per grade level, is the in crease gradual or irregular? 3. How does the ability of these adults compare with the ability of school pupils of corresponding grade levels?
Heat Shock Protein 27 Association with the IκB Kinase Complex Regulates Tumor Necrosis Factor α-induced NF-κB Activation (2003)

Heat shock protein 27 (Hsp27) is a ubiquitously expressed member of the heat shock protein family that has been implicated in various biological functions including the response to heat shock, oxidative stress, and cytokine treatment. Previous studies have demonstrated that heat shock proteins are involved in regulating signal transduction pathways including the NF-kappa B pathway. In this study, we demonstrated that Hsp27 associates with the I kappa B kinase (IKK) complex and that this interaction was stimulated by tumor necrosis factor alpha treatment. Phosphorylation of Hsp27 by the kinase mitogen-activated protein kinase-activated protein kinase 2, a downstream substrate of the mitogen-activated protein kinase p38, enhanced the association of Hsp27 with IKK beta to result in decreased IKK activity. Consistent with these observations, treatment of cells with a p38 inhibitor reduced the association of Hsp27 with IKK beta and thus resulted in increased IKK activity. These studies indicate that Hsp27 plays a negative role in down-regulating IKK signaling by reducing its activity following tumor necrosis factor alpha stimulation.
Research on alcohol metabolism among Asians and its implications for understanding causes of alcoholism. (1990)

Research into the causes of alcoholism is a relatively recent scientific endeavor. One area of study which could lead to better understanding of the disease is the possibility of a genetic predisposition to alcoholism. Recent work has demonstrated that people have varying complements of enzymes to metabolize alcohol. Current knowledge is examined about the influence of various ethanol metabolizing enzymes on alcohol consumption by Asians and members of other ethnic groups. The two principal enzymes involved in ethanol oxidative metabolism are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). ADH is responsible for the metabolism of ethanol to acetaldehyde. ALDH catalyzes the conversion of acetaldehyde to acetate. The different isozymes account for the diversity of alcohol metabolism among individuals. An isozyme of ADH (beta 2 beta 2) is found more frequently in Asians than in whites, and an ALDH isozyme (ALDH2), although present in Asians, often is in an inactive form. The presence of an inactive form of ALDH2 is thought to be responsible for an increase in acetaldehyde levels in the body. Acetaldehyde is considered responsible for the facial flushing reaction often observed among Asians who have consumed alcohol. A dysphoric reaction to alcohol, producing uncomfortable sensations, is believed to be a response to deter further consumption. Although the presence of an inactive ALDH2 isozyme may serve as a deterrent to alcohol consumption, its presence does not fully explain the levels of alcohol consumption by those with the inactive isozyme. Other conditions, such as social pressure, and yet undetermined biological factors, may play a significant role in alcohol consumption.
Hail Bruising of Fed Cattle (2019)

On May 25, 1999, a storm producing hail approximately 1 ¾ to 3¾ inches in diameter crossed over a feed yard. On four occasions following the storm, 409 carcasses from six pens were observed at an abattoir. On day 1, 29 carcasses were examined at the abattoir and in the grading cooler. On days 10, 15, and 49, additional cattle (n = 117, 173, and 90, respectively) were examined at the abattoir only. On day 16 following the first storm, a second storm, producing approximately 1 ¾-inch-diameter hail, crossed over the feed yard. Bruises were classified into three size categories, into short- and long-duration categories, and location was recorded. One hundred, 85, 54, and 44% of the carcasses exhibited bruises on days 1, 10, 15, and 49, respectively. On days 1, 10, 15, and 49, 100, 98, 65, and 27% of bruises were classified as short-duration. Multiple bruises were observed on 100, 75, 42, and 16% of carcasses on days 1, 10, 15, and 49, respectively. Storms producing hail approximately 3¾ inches in diameter have the potential to cause extensive bruising in cattle in open feed yards. Cattle sold within 15 days of such storms may experience significant hail-associated carcass trim loss, but by day 49 bruising appears to return to baseline levels.
A Reduced-Complexity MIMO Receiver via Channel Ordering (2009)

We consider the problem of maximum likelihood (ML) signal detection in multiple-input multiple-output (MIMO) wireless communication systems. We propose a new preprocessing algorithm in the form of channel ordering for sphere decoders. Numerical results show that this new channel ordering leads to significantly lower complexity (in the form of the number of nodes visited by the search algorithm); for MPSK modulation where M > 8 and a moderate SNR range of 15-24 dB, our channel ordering results in a two-fold to four-fold decrease in the number of nodes visited by the search algorithm. We also present a brief review of the SDR-ML detector, formulated using semidefinite programming and relaxation techniques. Finally, we propose a combined SDR-ML-sphere decoder and demonstrate that it further reduces the number of nodes visited by the search algorithm; for a 20 × 20 BPSK-modulated MIMO system and SNR of 8 dB, the SDR-ML-sphere decoder has an average complexity that is approximately 5 times less than the sphere decoder.
Fourier transform communication system (1969)

The development of rapid algorithms for computation of the discrete Fourier transform has encouraged the use of this transform in the design of communication systems. Here we describe and analyze a data transmission system in which the transmitted signal is the Fourier transform of the original data sequence and the demodulator is a discrete Fourier transformer. This system is a realization of the frequency division multiplexing strategy known as “parallel data transmission”, and it is constructed in this manner so that the data demodulator, after analog to digital conversion, may be a computer program employing one of the fast Fourier transform algorithms. The system appears attractive in that it may be entirely implemented by digital circuitry. We study the performance of this system in the presence of typical linear channel characteristics. It is shown, via computer simulation and computation of the variances of errors, how the system corrects linear channel distortion.
Amelioration of the Leaving Group Ability of the Aryl Sulfone Moiety via Intramolecular Oxygen Silylation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAmelioration of the Leaving Group Ability of the Aryl Sulfone Moiety via Intramolecular Oxygen SilylationP. C. Van Dort and P. L. FuchsCite this: J. Am. Chem. Soc. 1994, 116, 13, 5657–5661Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://doi.org/10.1021/ja00092a015RIGHTS & PERMISSIONSArticle Views528Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (708 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Monoclonal Antibody Epitope Mapping Describes Tailspike β-Helix Folding and Aggregation Intermediates (2005)

There is growing interest in understanding how the cellular environment affects protein folding mechanisms, but most spectroscopic methods for monitoring folding in vitro are unsuitable for experiments in vivo or in other complex mixtures. Monoclonal antibody binding represents a sensitive structural probe that can be detected against the background of other cellular components. A panel of antibodies has been raised against Salmonella typhimurium phage P22 tailspike. In this report, nine alpha-tailspike antibody binding epitopes were characterized by measuring the binding of these monoclonal antibodies to tailspike variants bearing surface point mutations. These results reveal that the antibody epitopes are distributed throughout the tailspike structure, with several clustered in the central parallel beta-helix domain. The ability of each antibody to distinguish between tailspike conformational states was assessed by measuring antibody binding to tailspike in vitro refolding intermediates. Interestingly, the binding of all but one of the nine antibodies is sensitive to the tailspike conformational state. Whereas several antibodies bind preferentially to the tailspike native structure, the structural features that comprise the binding epitopes form with different rates. In addition, two antibodies preferentially recognize early refolding intermediates. Combined with the epitope mapping, these results indicate portions of the beta-helix form early during refolding, perhaps serving as a scaffold for the formation of additional structure. Finally, three of the antibodies show enhanced binding to non-native, potentially aggregation-prone tailspike conformations. The refolding results indicate these non-native conformations form early during the refolding reaction, long before the appearance of native tailspike.
NITROGEN IN PROTEIN BODIES. (1903)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNITROGEN IN PROTEIN BODIES.Thomas B. Osborne and Isaac F. HarrisCite this: J. Am. Chem. Soc. 1903, 25, 4, 323–353Publication Date (Print):April 1, 1903Publication History Published online1 May 2002Published inissue 1 April 1903https://pubs.acs.org/doi/10.1021/ja02006a001https://doi.org/10.1021/ja02006a001research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
BiggerPicture (2014)

Filling a small hole in an image with plausible content is well studied. Extrapolating an image to give a distinctly larger one is much more challenging---a significant amount of additional content is needed which matches the original image, especially near its boundaries. We propose a data-driven approach to this problem. Given a source image, and the amount and direction(s) in which it is to be extrapolated, our system determines visually consistent content for the extrapolated regions using library images. As well as considering low-level matching, we achieve consistency at a higher level by using graph proxies for regions of source and library images. Treating images as graphs allows us to find candidates for image extrapolation in a feasible time. Consistency of subgraphs in source and library images is used to find good candidates for the additional content; these are then further filtered. Region boundary curves are aligned to ensure consistency where image parts are joined using a photomontage method. We demonstrate the power of our method in image editing applications.
Development and implementation of high-throughput SNP genotyping in barley (2009)

The unprecedented density of genic markers and marker bins enabled a high resolution comparison of the genomes of barley and rice. Low recombination in pericentric regions is evident from bins containing many more than the average number of markers, meaning that a large number of genes are recombinationally locked into the genetic centromeric regions of several barley chromosomes. Examination of US breeding germplasm illustrated the usefulness of BOPA1 and BOPA2 in that they provide excellent marker density and sensitivity for detection of minor alleles in this genetically narrow material.
Error-Prone Polymerase, DNA Polymerase IV, Is Responsible for Transient Hypermutation during Adaptive Mutation in <i>Escherichia coli</i> (2003)

The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV.
Microalbuminuria, endothelial dysfunction and cardiovascular risk. (2000)

Microalbuminuria was originally considered to be an important new risk factor for diabetic nephropathy. More recently, it has been convincingly shown that microalbuminuria is also an independent risk factor for cardiovascular morbidity and mortality in Type 1 and Type 2 diabetic patients. Even in the non-diabetic background population, microalbuminuria is a risk factor for cardiovascular mortality. What is the link between increased loss of albumin in urine and cardiovascular disease and mortality? As microalbuminuria is apparently associated with increased universal vascular sieving of albumin in terms of the transcapillary escape rate of albumin (TER-alb), microalbuminuria may reflect this universal sieving. The pathophysiology of increased TER-alb is unknown, but could be caused by haemodynamics or damage to the functional properties of the vascular wall. A number of studies have provided evidence of endothelial dysfunction in patients with microalbuminuria, which may be the common link accounting for the associations mentioned above. In this context, a number of markers of endothelial cell dysfunction have been found to be increased in patients with microalbuminuria. In addition, a number of functional in vivo tests of endothelial dysfunction have been performed in Type 1 and Type 2 diabetic patients as well as in normal controls. Overall, these studies indicate the existence of a functional vascular dysfunction in Type 1 diabetic patients and normal controls with microalbuminuria, which may be related to dysfunction of endothelial cells.
Robust Learning Under Label Noise With Iterative Noise-Filtering (2019)

We consider the problem of training a model under the presence of label noise. Current approaches identify samples with potentially incorrect labels and reduce their influence on the learning process by either assigning lower weights to them or completely removing them from the training set. In the first case the model however still learns from noisy labels; in the latter approach, good training data can be lost. In this paper, we propose an iterative semi-supervised mechanism for robust learning which excludes noisy labels but is still able to learn from the corresponding samples. To this end, we add an unsupervised loss term that also serves as a regularizer against the remaining label noise. We evaluate our approach on common classification tasks with different noise ratios. Our robust models outperform the state-of-the-art methods by a large margin. Especially for very large noise ratios, we achieve up to 20 % absolute improvement compared to the previous best model.
Evolution of the surface composition and topography of perfluorinated polymers following ammonia-plasma treatment (1994)

Treatment of fluorinated ethylene propylene (FEP) and polytetrafluoroethylene (PTFE) in ammonia plasmas produced surfaces with very high wettability by water, but on storage in air at ambient temperature, the air/water contact angles increased markedly. The evolution of the surface composition and topography was studied by angle-dependent X-ray photoelectron spectroscopy (XPS), derivatization of amine groups with fluorescein isothiocyanate, scanning tunelling microscopy (STM), and atomic force microscopy (AFM). XPS demonstrated a continuous increase in the oxygen content over periods of weeks; this was assigned to oxidation of trapped radicals and subsequent secondary reactions. In addition, the fluorine content also changed markedly on storage; the XPS fluorine signal suggested that there was a substantial amount of fluoride in the freshly treated surfaces, and this component disappeared rapidly on storage. STM and AFM showed no changes in topography with aging but suggested surface hardening on plasma treatment. The events following treatment of FEP and PTFE in ammonia plasmas are not adequately described by a model involving plasma-induced, instantaneous chemical modification followed by surface restructuring; the surface and sub-surface compositions evolve over a period of several weeks due to the occurrence of oxidative reactions, and these chemical changes interact with the physical process of surface restructuring.
Bone Marrow-Derived Cells Are Present in Mooren’s Ulcer (2004)

To investigate whether bone marrow-derived cells are present in Mooren's ulcer and involved in its destructive and regenerative disease course, tissue specimens were collected from 3 eyes of 3 patients with Mooren's ulcer that underwent lamellar keratectomy. Three normal donor limbal corneoscleras served as controls. Immunohistochemical staining patterns were analyzed by using the following antibodies: CD34 (a marker of hematopoietic progenitor cells and endothelium), c-kit (a marker of hematopoietic and stromal progenitor cells) and STRO-1 (a differentiation antigen present on bone marrow fibroblast cells and on various nonhematopoietic progenitor cells). Strong positive CD34, c-kit and STRO-1 cells were revealed in Mooren's ulcer specimens, especially in the superficial stroma. A few weakly expressed CD34 stromal cells were seen in normal limbal cornea, but no immunoreactivity for c-kit and STRO-1 was found. Bone marrow-derived cells are present in Mooren's ulcer and contribute to its destructive and regeneration process by synergizing with other factors. Specific therapeutic strategies that target the role of these cells in Mooren's ulcer are anticipated.