gebhart/patrepeval huggingface dataset:
[Endoscopic injection of methotrexate bound to activated carbon particles in the treatment of gastric cancer]. (1995)

A new dosage formulation (MTX-CH), composed of fine activated carbon particles absorbing methotrexate (MTX), distributes concentrated MTX for long periods of time to the regional lymph nodes as well as to the injection site, in animal experiments. MTX-CH would enhance the therapeutic effects not only on the primary lesion but also on the lymphatic metastasis. As clinical trials, (A) in five patients with early gastric cancer, MTX-CH at 50 to 200 mg/person of MTX was injected endoscopically in and around the primary lesion before operation. Surgically removed specimens showed that three out of the 5 primary lesions had disappeared or were necrotic, and the remaining two lesions had shrunk. (B) Three patients with contraindication to surgery received the endoscopic injection of MTX-CH. The MTX-CH injected at 250 to 1,500 mg/person into and around the primary lesion of relatively early gastric cancer resulted in the complete disappearance of the primary lesions for 14 to 24 months up to the present time without enlargement of the lymph nodes. It was thought that local injection of MTX-CH will be effective therapy, especially for gastric cancer with potential lymphatic metastasis in patients with contraindications to surgery.
Banners, e-mail, advertainment and sponsored search: proposing a value perspective for online advertising (2005)

In this paper, we describe the state-of-the-art in online advertising, addressing particularly the service innovation in the industry, at least partly developed as a solution to the crisis of the end 1990s. We claim that the approach based on cognitive intrusion does not fit the value expectations of the consumers and ultimately, the strategic goals of the firm. Our conclusion is also that permission marketing (on which the e-mail marketing techniques are based) does not solve the problems of online advertising, because it does not fit the needs of the advertisers, or those of the consumers, in the early stages of the relationship. We provide arguments and empirical evidence (primary and secondary) for supporting our statements. We propose a new model of evaluation and management of online advertising, based on the customer value perspective. Since the service innovation in the field is not limited to rich-media banners and e-mail marketing, we try to find the new techniques that better fit a customer value philosophy of online advertising. Lastly, we also highlight the critical aspects of these new online advertising domains.
Stochastic Modeling and Dynamic Analysis of the Cardiovascular System with Rotary Left Ventricular Assist Devices (2019)

Left ventricular assist devices (LVADs) have been used for end‐stage heart failure patients as a therapeutic option. The aortic valve plays a critical role in heart failure and its treatment with a LVAD. The cardiovascular‐LVAD model is often used to investigate the physiological demands required by patients and predict the hemodynamic of the native heart supported with a LVAD. As it is a “ bridge-to-recovery ” treatment, it is important to maintain appropriate and active dynamics of the aortic valve and the cardiac output of the native heart, which requires that the LVAD pump be adjusted so that a proper balance between the blood contributed through the aortic valve and the pump is maintained. In this paper, we investigate how the pump power of the LVAD pump can affect the dynamic behaviors of the aortic valve for different levels of activity and different severities of heart failure. Our objective is to identify a critical value of the pump power (i.e., breakpoint ) to ensure that the LVAD pump does not take over the pumping function in the cardiovascular‐pump system and share the ejected blood with the left ventricle to help the heart to recover. In addition, the hemodynamic often involves variability due to patients’ heterogeneity and the stochastic nature of the cardiovascular system. The variability poses significant challenges to understanding dynamic behaviors of the aortic valve and cardiac output. A generalized polynomial chaos (gPC) expansion is used in this work to develop a stochastic cardiovascular‐pump model for efficient uncertainty propagation, from which it is possible to rapidly calculate the variance in the aortic valve opening duration and the cardiac output in the presence of variability. The simulation results show that the gPC‐based cardiovascular‐pump model is a reliable platform that can provide useful information to understand the effect of the LVAD pump on the hemodynamic of the heart.
One-Year Clinical Results With the Slow-Release, Polymer-Based, Paclitaxel-Eluting TAXUS Stent (2004)

The relative efficacy reported at 9 months for the polymer-based, paclitaxel-eluting TAXUS stent compared with the EXPRESS stent is preserved and continues to increase at 1 year, with no safety concerns apparent.
Falsely increased HbA1c values by HPLC and falsely decreased values by immunoassay lead to identification of Hb Okayama and help in the management of a diabetic patient. (2000)

A falsely increased HbA1c value of 47.1% was determined by cation exchange chromatography during a routine HbA1c measurement of the blood sample from a 63-year-old diabetic male patient living in Hamburg, Germany. In former determinations by immunological assays falsely decreased values in the range of 5.0 to 5.5% were obtained. The sample was inconspicuous in alkaline hemoglobin electrophoresis. But acid hemoglobin electrophoresis confirmed the falsely increased value. These facts let us consider the existence of a heterozygous "silent hemoglobin variant", such as hemoglobin Okayama, with an amino acid substitution in one of the first four amino acids of the beta chain, representing the epitope of common immunoassays. DNA analyses confirmed this presumption and we found the heterozygous mutation hemoglobin Okayama [beta 2 (NA 2) His (CAC)-->Gln (CAA)]. Knowing that an immunological assay only detects about half of the present HbA1c, the obtained values can be used for therapeutic management of this diabetic patient.
High Yielding Synthesis of Carboranes Under Mild Reaction Conditions Using a Homogeneous Silver(I) Catalyst: Direct Evidence of a Bimetallic Intermediate (2014)

Methods used to prepare functionalized carboranes generally require heating to high temperatures, and thus limits the range of derivatives which can be prepared directly from alkynes. We show here that by using a homogeneous silver(I) catalyst it is now possible to prepare carboranes in good to excellent yield at temperatures below 40 °C, including at room temperature. The process is general and provides an important new synthetic strategy for the preparation of functionalized boron clusters.
Codebook Design for Uniform Rectangular Arrays of Massive Antennas (2013)

Massive Multiple-Input Multiple-Output (MIMO) is an emerging research field due to the increasing demand of spectral efficiency in wireless broadband systems, such as Long Term Evolution (LTE) which is proposed by 3GPP (Third Generation Partnership Project). Precoding is important to exploit the performance of massive MIMO, and codebook design is crucial due to the limited feedback channel. In this paper, we propose a novel double codebook design method based on a Kronecker-type approximation of the array correlation structure for the uniform rectangular array, which is preferable for the antenna deployment of massive MIMO systems. As a case study, we run simulations based on assumptions of the LTE-Advanced system which is extended to 32 dual-polarized antennas. The results verify that the proposed codebook design has remarkable performance gain compared to the traditional double codebook under the uniform rectangular array setup.
ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy. (2000)

To enhance the inhibitory potential of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) vs hepatitis C virus (HCV) NTPase/helicase, ribavirin-5'-triphosphate (ribavirin-TP) was synthesized and investigated. Ribavirin-TP was prepared with the use of modified Yoshikawa-Ludwig-Mishra-Broom procedure (cf. Mishra & Broom, 1991, J. Chem. Soc., Chem. Commun, 1276-1277) involving phosphorylation of unprotected nucleoside. Kinetic analysis revealed enhanced inhibitory potential of ribavirin-TP (IC50=40 microM) as compared to ribavirin (IC50 > 500 microM). Analysis of the inhibition type by means of graphical methods showed a competitive type of inhibition with respect to ATP. In view of the relatively low specificity towards nucleoside-5'-triphosphates (NTP) of the viral NTPase/helicases, it could not be ruled out that the investigated enzyme hydrolyzed the ribavirin-TP to less potent products. Investigations on non- hydrolysable analogs of ribavirin-TP or ribavirin-5'-diphosphate (ribavirin-DP) are currently under way.
Close to collinear acousto-optical interaction in paratellurite (1992)

First results on the investigation of close to collinear coustooptical interaction in paratellurite single crystals are presented. Anisotropic Bragg diffraction of light on ultrasound in TeO<sub>2</sub> with a length of interaction of up to several centimeters is examined. A peculiarity of the interaction is optical beam propagation in the crystal collinearly with group velocity of ultrasound. It is shown and verified experimentally that the interaction is characterized by an extremely high selectivity of scattering. Some applications of the examined regime of diffraction are discussed.
Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits (1993)

Human granulocyte-macrophage colony-stimulating factor (GM-CSF) controls the production, maturation, and function of cells in multiple hematopoietic lineages. These effects are mediated by a cell-surface receptor (GM-R) composed of alpha and beta subunits, each containing 378 and 881 amino acids, respectively. Whereas the alpha subunit exists as several isoforms that bind GM-CSF with low affinity, the beta common subunit (beta c) does not bind GM-CSF itself, but acts as a high- affinity converter for GM-CSF, interleukin-3 (IL-3), and IL-5 receptor alpha subunits. The cytoplasmic region of GM-R alpha consists of a membrane-proximal conserved region shared by the alpha 1 and alpha 2 isoforms and a C-terminal variable region that is divergent between alpha 1 and alpha 2. The cytoplasmic region of beta c contains membrane proximal serine and acidic domains. To investigate the amino acid sequences that influence signal transduction by this receptor complex, we constructed a series of cytoplasmic truncation mutants of the alpha 2 and beta subunits. To study these truncations, we stably transfected the IL-3-dependent murine cell line Ba/F3 with wild-type or mutant cDNAs. We found that the wild-type and mutant alpha subunits conferred similar low-affinity binding sites for human GM-CSF to Ba/F3, and the wild-type or mutant beta subunit converted some of these sites to high- affinity; the cytoplasmic domain of beta was unnecessary for this high- affinity conversion. Proliferation assays showed that the membrane- proximal conserved region of GM-R alpha and the serine-acidic domain of beta c are required for both cell proliferation and ligand-dependent phosphorylation of a 93-kD cytoplasmic protein. We suggest that these regions may represent an important signal transduction motif present in several cytokine receptors.
Microlens fabricated by the planar process (1991)

A novel microlens that can be integrated on a laser-diode substrate by the planar process is proposed. It consists of two microcylindrical lenses fabricated by the planar process, and all of their dimensions are less than 100 mu m. One lens is a horizontal focusing lens whose curved shape determines focusing. The other is a vertical focusing lens whose gradient refractive index determines focusing. The relationship between fabrication errors and lens characteristics is quantitatively established by comparing lenses with various fabrication errors. Also a laser diode integrated with the horizontal focusing lens is successfully fabricated without damage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Risk Identification and Mitigation Processes for Using Scrum in Global Software Development: A Conceptual Framework (2009)

There is growing interest in applying agile practices in Global Software Development (GSD) projects. But project stakeholder distribution in GSD creates a number of challenges that make it difficult to use some agile practices. Moreover, little is known about what the key challenges or risks are, and how GSD project mangers deal with these risks while using agile practices. We conduct a Systematic Literature Review (SLR) following existing guidelines to identify primary papers that discuss the use of Scrum practices in GSD projects. We identify key challenges, due to global project distribution, that restrict the use of Scrum and explore the strategies used by project managers to deal with these challenges. Our findings are consolidated into a conceptual framework and we discuss various elements of this framework. This research is relevant to project managers who are seeking ways to use Scrum in their globally distributed projects.
Effect of strain on the magnetoexciton ground state in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">InP</mml:mi><mml:mo>/</mml:mo><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ga</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">In</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi>−</mml:mi><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mi mathvariant="normal">P</mml:mi></mml:math>quantum disks (2003)

The ground-state properties of an exciton in a self-assembled quantum disk are calculated in the presence of a perpendicular magnetic field. For sufficient wide and thin dots, the strain field leads to a confinement of the heavy hole within the dot and the system is type I, while the light hole is confined outside the dot and the system is type II. However, with increasing disk thickness, the strain induces a transition of the heavy hole from inside the disk towards the radial boundary outside the disk. For the exciton, we predict a heavy-hole to light-hole transition as a function of the disk thickness, i.e., forming a ``ringlike'' hole wave function. There is a range of parameters (radius and height of the disk) for which a magnetic field can induce such a heavy-to-light hole transition. The diamagnetic shift was compared with results from magnetophotoluminescence experiments, where we found an appreciable discrepancy. The origin of this discrepancy was investigated by varying the disk parameters, the valence-band offset, and the effective masses.
Mutations in the long QT gene, KCNQ1, are an uncommon cause of atrial fibrillation: Table 1 (2004)

Atrial fibrillation (AF) is the most common clinical arrhythmia and a major source of morbidity and mortality.1 The underlying mechanisms for AF are highly heterogeneous and often related to associated structural heart disease.2 However, in several large studies 10–30% of subjects have no obvious heart disease, and are labelled as primary or lone AF.1

The identification of extended families with lone AF, and the mapping of discrete genetic loci in such families, raises the possibility that the heritable predisposition to this form of the arrhythmia is accessible.3,4 Recently, the first gene for an inherited form of AF was identified in a family with autosomal dominant transmission.5 A mutation was found in the first transmembrane spanning domain of the potassium channel gene, KCNQ1, resulting in serine-glycine substitution (S140G). Mutations in other residues throughout this gene cause long QT syndrome type 1 (LQT1). Co-expression of the S140G mutant allele with KCNE1 in cells results in a gain of function with increased current density, and an alteration of channel activation and inactivation. These observations contrast with the reduction in current density seen with LQT1 associated mutations. The unique phenotype associated with this activating mutation includes persistent AF and, surprisingly, QT prolongation. This …
90-nm-node multi-level AG-AND type flash memory with cell size of true 2 F/sup 2//bit and programming throughput of 10 MB/s (2004)

The first true 2-F/sup 2//bit flash cell with a programming throughput of 10 MB/s was developed. In this cell, diffusion-layer local bit lines of an assist-gate AND-type flash are replaced by inversion-layer ones under assist gates. The bit-line pitch is thus reduced to 2 F. A drain-disturbance-free and soft-write-free flash cell was produced by means of a new diffusion-layer-less technology. Source-side injection programming is applicable to the new flash cell; therefore, the cell programming time is reduced to 1 /spl mu/s. The smallest memory cell (0.0162 /spl mu/m/sup 2//bit) achieved to date was accomplished by using a 90-nm technology node and applying multi-level cell technology.
Inhibitors or Tryptophan, Phenylalanine, and Tyrosine Biosynthesis as Herbicides (1998)

In plants, the plastids appear to be the major site of biosynthesis of the aromatic amino acids in which all of the enzymes of the pathway can be detected (Mousdale and Coggins 1985). The entry point for the shikimate pathway is 3-deoxy-D-arabino-heptulosonate 7 phosphate synthase (DAHPS; refer to Scheme 1), and it has been under study as a possible herbicide target. This enzyme catalyzes the condensation of o-erythrose-4-phosphate (E4P) with phosphoenolpyruvate (PEP) to form DAHP. The DAHPS-catalyzed reaction is uncommon for PEP-using enzymes, in that it results in C-o, rather than P-o, bond cleavage of PEP, with resulting C-e bond formation. EPSPS catalyzes C-O bond cleavage as well, but results in C-O-C enol ether linkage by a very different chemical mechanism (discussed later). In the DAHPS reaction the C-3 carbon of PEP is the nucleophile that attacks the carbonyl carbon of E4P, whereas the C-2 carbon of PEP undergoes nucleophilic addition of water.
Metals, ligands, and cancer (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetals, ligands, and cancerDavid R. WilliamsCite this: Chem. Rev. 1972, 72, 3, 203–213Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://pubs.acs.org/doi/10.1021/cr60277a001https://doi.org/10.1021/cr60277a001research-articleACS PublicationsRequest reuse permissionsArticle Views1973Altmetric-Citations301LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A QoS Architecture for IOT (2011)

The application-oriented IoT is an integration of various kinds of technologies, rapidly developing in the globe. To ensure the quality its practical use, it is necessary to research its QoS architecture. We summarize QoS requirements through analysis of characteristic of IoT application service, transmission network, perception in this paper. Then we propose a QoS architecture based on IoT layered structure. This architecture sets QoS agent in lower layers then transmits QoS requirements, trying to guarantee the consistency as well as effectively use the existing QoS mechanisms in every layer.
Investigation of direct cooling in drawing steel wire (1984)

Experimental set‐up of direct cooling in drawing steel wire. Calculation of the obtainable temperature drop in cooling tubes. Cooling rates measured at different operation parameters. Evaluation of friction coefficient. Thickness measurement of lubricant layers. Examination of mechanical properties of drawn wire.
ThinSight: A new interaction technology for ubicomp (2007)

We present a novel technology suitable for situated displays, called ThinSight. It combines up close zero-force multi-touch interaction, with interaction and data exchange from a distance using a mobile device. The novelty of ThinSight lies both in the combination of these features and in the thin formfactor of the hardware which can be fully integrated into commercially available LCDs without affecting display quality. This readily deployable situated display technology opens up many new ubiquitous computing possibilities.
Coupling between the left ventricle and arterial system in hypertension (1990)

In youth and in health, a variety of factors combine to optimize coupling between the left ventricle and systemic circulation. In hypertension and with aging, optimal coupling is disturbed by increased arterial stiffness which increases systolic pressure through two different mechanisms. The first mechanism (reduced aortic compliance) is not directly affected by drugs, but the second (early wave reflection) is capable of modification by vasodilator therapy. Favourable effects of vasodilator agents may not be apparent when pressure is recorded conventionally in a peripheral artery but can be inferred from consideration of pressure wave contour. Recognition of these factors provides new strategies for dealing with hypertension and hypertensive heart failure in man.
Parallel UPS with a instantaneous current sharing control (2002)

This paper proposes a novel instantaneous current sharing control scheme ensuring a fast dynamic response and an equal load sharing capability in a parallel connected UPS (inverter). The proposed novel instantaneous current sharing control scheme is based on the instantaneous output voltage control with the current deviation control and the instantaneous current deviation cancellation control utilizing the current share bus circuit. The proposed novel instantaneous current sharing control circuitry employs the share bus signal line interconnecting all the paralleled inverter on a noise insensitive line. The voltage control circuitry forces all the paralleled inverters to share load current, almost equally, by adjustment of the instantaneous reference voltage signal obtained from the current share bus. With the current share bus and the current deviation controller, the paralleled inverter with the highest output current becomes the master inverter; then all the other inverters become slave inverters. The instantaneous output current of the master inverter is subtracted from the other inverters' output currents, and the current deviations in each inverter module are calculated. Hereafter, the instantaneous current sharing controller forces the output current deviations of each inverter to be zero in every switching period. Furthermore, the output reference of the voltage controller is instantaneously to eliminate the unbalanced power. This results in superior power balance performance for parallel operation.