gebhart/patrepeval huggingface dataset:
The Use of Dimethyl Sulfoxide (DMSO) in the Treatment of Interstitial Cystitis (1967)

No AccessJournal of Urology1 Dec 1967The Use of Dimethyl Sulfoxide (DMSO) in the Treatment of Interstitial Cystitis Bruce H. Stewart, Lester Persky, and William S. Kiser Bruce H. StewartBruce H. Stewart More articles by this author , Lester PerskyLester Persky More articles by this author , and William S. KiserWilliam S. Kiser More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62954-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "The Use of Dimethyl Sulfoxide (DMSO) in the Treatment of Interstitial Cystitis." The Journal of Urology, 98(6), pp. 671–672 © 1967 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMacDermott J, Charpied G, Tesluk H and Stone A (2018) Recurrent Interstitial Cystitis following Cystoplasty: Fact or Fiction?Journal of Urology, VOL. 144, NO. 1, (37-40), Online publication date: 1-Jul-1990.Greenberg E, Barnes R, Stewart S and Furnish T (2018) Transurethral Resection Of Hunner’s UlcerJournal of Urology, VOL. 111, NO. 6, (764-766), Online publication date: 1-Jun-1974.Kerr W (2018) Interstitial Cystitis: Treatment by Transurethral ResectionJournal of Urology, VOL. 105, NO. 5, (664-666), Online publication date: 1-May-1971. Volume 98Issue 6December 1967Page: 671-672 Advertisement Copyright & Permissions© 1967 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Bruce H. Stewart More articles by this author Lester Persky More articles by this author William S. Kiser More articles by this author Expand All Advertisement Loading ...
A 4 Gb DDR SDRAM with gain-controlled pre-sensing and reference bitline calibration schemes in the twisted open bitline architecture (2002)

A 1.8 V 4 Gb DDR SDRAM for low voltage and high speed at full density has reduced inter-bitline coupling noise in the twisted open bit line architecture. Amplifier sensitivity and sensing margin are improved by gain-controlled pre-sensing and active calibration of the bitline reference voltage. For noise-immune power-stabilized operation, three circuit schemes suitable for the SDRAM are presented: (i) twisted open bitline (TOB) architecture; (ii) gain-controlled pre-sensing (GCP); and (iii) reference bitline calibration (RBC). The TOB scheme eliminates the coupling noise between adjacent BLs by holding neighboring bitlines stable at the reference voltage with the open readout and sensing using a reference BL from the adjacent block. The GCP scheme increases the sensing margin and speed by employing transconductance-matched pre-amplification. The RBC scheme actively mimics the cell data retention characteristics and yields an optimal voltage level for the reference BL from the charge-shared voltage from replica BL pairs. Together with a chip-size-efficient core signal repeating architecture, these schemes ensure reliable low-voltage and high-speed cell and core operation.
The First Example of Activation of Molecular Oxygen by Nickel in Ni-Al Hydrotalcite: A Novel Protocol for the Selective Oxidation of Alcohols (2001)

NiO in association with aluminum oxide has been identified by temperature-programmed reduction as the active species in the Ni–Al hydrotalcite catalyst that oxidizes α-ketols as well as benzylic and allylic alcohols to their corresponding carbonyl compounds in oxygen in quantitative yields under mild reaction conditions (see scheme).
Augmentation of central arterial pressure in type 1 diabetes. (1999)

These findings suggest that central systolic blood pressure is increased in relatively young individuals with type 1 diabetes, although myocardial perfusion related to cardiac workload is decreased. These changes can be explained by more rapid pulse-wave velocity resulting from arterial stiffening.
Early diagnosis of acute myocardial infarction. (1990)

Acute myocardial infarction is usually caused by thrombotic occlusion of a coronary artery. The left ventri -ular subendocardium infarcts within 30 minutes, but extension to affect the full thickness of the ventricular wall may take several hours.' The size of the infarct depends largely on the distribution of the occluded artery, although collateral vessels or spontaneous recanalisation may limit it to the subendocardial layer.'" Thrombolytic treatment also limits the size of the infarct if coronary recanalisation occurs before the transmural spread of infarction is complete.4 This reduces mortality in patients treated within 24 hours after the onset of symptoms, although the benefit is greater the earlier treat- ment is given.67 Early diagnosis is therefore important.
Triacetin Enhances Levels of Acrolein, Formaldehyde Hemiacetals, and Acetaldehyde in Electronic Cigarette Aerosols (2018)

The health effects of inhaled electronic cigarette (e-cigarette) flavoring compounds are largely unknown. Earlier reports of their chemical reactivity have been conflicting, with some claiming, for example, that the degradation of flavoring chemicals in e-cigarettes to aldehydes is statistically insignificant. It is thus important to understand how these molecules react to afford enhanced aerosol products. The purpose of the current study was to investigate the origin of formaldehyde, acrolein, and acetaldehyde in e-cigarettes that contain the popular additive, triacetin (TA). By using <sup>13</sup>C labeling and a combination of <sup>1</sup>H NMR and <sup>13</sup>C NMR, we were able to identify that ester hydrolysis of TA occurs to form acetic acid (HOAc) during aerosolization. The released HOAc acts as a catalyst in the degradation of propylene glycol (PG) and glycerol (GLY), increasing the formation of formaldehyde hemiacetals, acrolein, and acetaldehyde. A solution of 10% TA in 1:1 PG/GLY e-liquid was aerosolized using two different e-cigarettes at two wattages. Each device exhibited a significant increase in aldehyde levels, of up to 185% compared to the aerosol from a 1:1 PG/GLY e-liquid. In addition, the GLY formaldehyde hemiacetal was more predominant within the presence of HOAc, indicating that GLY may be relatively more prone to degradation from protonation.
Structure and function of neuromuscular junction, centered on muscle‐specific tyrosine kinase and related proteins (2016)

Abstract Muscle‐specific tyrosine kinase (Mu SK ) is uniquely positioned as a key protein in the neuromuscular junction, particularly in relation to acetylcholine receptor ( AC hR) clustering in the postsynaptic membrane, and pre‐ and postsynaptic differentiations. The present review focuses on the functional mechanisms in the neuromuscular junction structures centered on Mu SK and related proteins. (i) The Wnt non‐canonical pathway through the Wnt/Mu SK cysteine‐rich domain (coreceptor: low‐density lipoprotein receptor‐related protein 4 [Lrp4])/Dishevelled (scaffolding protein) signaling; this localizes aneural microclusters of AC hR at the central part of the postsynaptic membrane in parallel with axonal guidance, and converges on the neural agrin/Lrp4/Mu SK immunoglobulin‐like domains 1 and 2 (Ig 1/2 domains) pathway to form innervated full‐sized AC hR clusters. (ii) The presynaptic homeostasis (upregulation of acetylcholine release) compensates postsynaptic impairments by the fast‐mode of endocytosis in the nerve terminal and the trans‐synaptic retrograde signals including Wnt‐Mu SK cysteine‐rich domain canonical pathway (including β‐catenin), Lrp4 and laminin β2. (iii) The extracellular matrix contributive to the neuromuscular junction formation and maintenance includes collagen Q, perlecan, biglycan and dystroglycans; collagen Q and biglycan link to Mu SK (first and second immunoglobulin‐like domains and cysteine‐rich domain) and acetylcholinesterase on one hand and to the intracellular cytoskeleton through dystroglycans on the other hand, so that Mu SK participates in not only AC hR clustering at the muscle surface and acetylcholinesterase‐controlled muscle membrane sensitivity to acetylcholine, but also the postsynaptic stability reinforced by cytoskeletal dynamics; the laminin network including muscle agrin also contributes to synaptic stability through dystroglycans; the agrin‐enhanced phosphorylation of cortactin promotes cytoskeletal dynamics to stabilize AC hR clusters; the interaction of neuregulin 1 with the receptor tyrosine kinase of EGF receptor family (ErbB receptor) contributes to the postsynaptic stabilization and also Mu SK phosphorylation leading to AC hR clustering. (iv) The muscle contractile mechanisms are controlled by release and restoration of the sarcoplasmic Ca 2+ being mediated through the receptor and channel proteins. Insight into these fine structures will foster further immunological approaches to search for new antigenic targets and to enhance antibody detection in myasthenia gravis.
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans (2002)

Administration of the cytokines interferon-alpha and interleukin-2 is used for the treatment of various disorders, such as hepatitis C and various forms of cancer. The most serious side-effects are symptoms associated with depression, including fatigue, increased sleepiness, irritability, loss of appetite as well as cognitive changes. However, great differences exist in the prevalence of the development of depressive symptoms across studies. Differences in doses and duration of therapy may be sources of variation as well as individual differences of patients, such as a history of psychiatric illness. In addition, sensitization effects may contribute to differential responses of patients to the administration of cytokines. In animals administration of pro-inflammatory cytokines induces a pattern of behavioural alterations called 'sickness behaviour' which resembles the vegetative symptoms of depression in humans. Changes in serotonin (5-HT) receptors and in levels of 5-HT and its precursor tryptophan in depressed people support a role for 5-HT in the development of depression. In addition, evidence exists for a dysregulation of the noradrenergic system and a hyperactive hypothalamic-pituitary-adrenal (HPA) axis in depression. Some mechanisms exist which make it possible for cytokines to cross the blood-brain barrier. Pro-inflammatory cytokines such as IL-1beta, IFN-alpha, IFN-gamma and TNF-alpha affect the 5-HT metabolism directly and/or indirectly by stimulating the enzyme indoleamine 2,3-dioxygenase which leads to a peripheral depletion of tryptophan. IL-1, IL-2 and TNF-alpha influence noradrenergic activity and IL-1, IL-6 and TNF-alpha are found to be potent stimulators of the HPA axis. Altogether, administration of cytokines may induce alterations in the brain resembling those found in depressed patients, which leads to the hypothesis that cytokines induce depression by their influence on the 5-HT, noradrenergic and HPA system.
Energy functions for the segmentation of ultrasound volume data using active rays (2002)

In this paper we address the problem of ultrasound volume data segmentation by means of active contours. The segmentation is performed on an slice-by-slice basis but exploiting the high correlation that exists across nearby slices. We have used active rays to alleviate the computational load of the optimization process. Classical energy functions have trouble finding the optimal solution in speckle imagery. We therefore propose new energy functions that work well under this type of images. Moreover, we propose both a probabilistic relaxation scheme and a heuristic search of the minimal energy configuration to end up making a hybrid use of both. We compare two rendered surfaces to illustrate the smoothness of our reconstruction.
Symptoms Associated With Tamoxifen Treatment in Postmenopausal Women (1991)

Adjuvant breast cancer therapy with tamoxifen is associated with greater disease-free survival and possibly overall survival. Long-term treatment, possibly of indefinite duration, is being evaluated. Compliance with long-term therapy will depend largely on the nature and severity of tamoxifen's side effects. We evaluated the symptoms associated with tamoxifen therapy in 140 postmenopausal women with axillary node negative breast cancer in remission (mean years since menopause, 9.3) enrolled in a placebo-controlled, randomized toxicity study. Tamoxifen recipients reported moderated or severe vasomotor symptoms up to 17%, and gynecologic symptoms up to 4% more frequently than placebo subjects. Persistent vasomotor, gynecologic, or other major side effects were reported by 48% of tamoxifen recipients, and by 21% of placebo subjects. These carefully collected data suggest significant perceived symptom 'cost' of tamoxifen therapy in postmenopausal women, of a magnitude likely to compromise long-term compliance.
Identification of connexin43 as a functional target for Wnt signalling (1998)

Wnt mediated signal transduction is considered to regulate activity of target genes. In Xenopus embryos, ectopic Wnt1 and Wnt8 expression induces gap-junctional communication. During murine brain formation, Wnt1 and the gap-junctional protein connexin43 (Cx43) are co-expressed at the mid/hindbrain border, while interference with Wnt1 or Cx43 expression during embryogenesis leads to severe brain defects in the mid/hindbrain region. In PC12 cells, Wnt1 expression leads to an apparent increase in cell-cell adhesion. We investigated the effects of Wnt1 overexpression on gap-junctional communication in PC12 cells. Wnt1 expressing clones displayed an increased electrical and chemical coupling. This coincides with an increased expression of Cx43 mRNA and protein, while other connexins, Cx26, Cx32, Cx37, Cx40 and Cx45, were not up-regulated. Also, induction of Wnt1 expression in a mammary epithelial cell line leads to an increase in gap-junctional communication and Cx43 protein expression. In transient transactivation assays in P19 EC cells we found that Wnt1 and Li+, an ion that mimics Wnt signalling, increased transcription from the rat Cx43 promoter, potentially via TCF/LEF binding elements, in a pathway separate from cAMP-induced Cx43 transactivation. The results demonstrate that Cx43 acts as a functional target of Wnt1 signalling, and Cx43 expression can be regulated by Wnt1 at the transcriptional level. Our data suggest that Wnt1-induced cell fate determination is likely to involve regulation of gap-junctional communication.
Significance of Cyclin D1 Polymorphisms in Patients with Head and Neck Cancer (2012)

Cyclin D1 plays a key role in cell cycle control, particularly in the transition from G1 to S phase, regulated by cyclin-dependent kinases. The objective of the present study was to screen the cyclin D1 gene (CCND1) for polymorphisms in patients with head and neck cancer (HNC). Genomic DNA was isolated from blood samples of 380 HNC patients and 350 controls. In a hospital-based case-control study using the PCR-SSCP technique we found 3 novel germline mutations: g3578C>A, g3475G>C and g3383delA. The commonly reported guanine to adenine polymorphisms in exon 4 g7656G>A (rs9344) and g10861C>A (rs7177) in 3'UTR of CCND1 were also observed. The calculated frequencies of the g7656G>A (rs9344) polymorphism in GG, GA and AA genotypes were 27.3%, 38.6%, and 33.9% in HNC cases, and 44.2%, 29.4%, and 26.2% in normal healthy controls, respectively. Adjusted by age (in years), sex and smoking status, multivariate logistic regression analysis showed that the AA and GA genotypes were associated with a significantly increased risk (OR 1.34, 95% CI 1.03-1.64, p=0.028) for HNC. The CCND1 AA genotype variant was associated with an increased risk in individuals who were <40 years old (OR 1.45, 95% CI 1.02-2.08, p=0.04). In conclusion, it is suggested that the CCND1 G/A polymorphism is associated with the early onset of HNC and may contribute to HNC susceptibility in a Pakistani population.
Registration-by-regression of coronary CTA and X-ray angiography (2015)

We evaluate the integration of 3D preoperative computed tomography angiography of the coronary arteries with intraoperative 2D X-ray angiographies by a recently proposed novel registration-by-regression method. The method relates image features of 2D projection images to the transformation parameters of the 3D image. We compared different sets of features and studied the influence of preprocessing the training set. For the registration evaluation, a gold standard was developed from eight X-ray angiography sequences from six different patients. The alignment quality was measured using the 3D mean target registration error (mTRE). The registration-by-regression method achieved moderate accuracy (median mTRE of 15 mm) on real images. It does therefore not provide yet a complete solution to the 3D–2D registration problem but it could be used as an initialisation method to eliminate the need for manual initialisation.
Wide-speed operation of interior permanent magnet synchronous motors with high-performance current regulator (1994)

Interior permanent magnet synchronous motors can be applied to applications requiring wide-speed operation. The current vector control algorithm of an interior permanent magnet synchronous (IPM) motor for constant power operation over the base speed is proposed. As the available voltage controlling the armature current vector is small in the flux-weakening constant power region, the current vector sometimes becomes uncontrollable in transient operations because of the current regulator saturation. The high-performance current regulator is also proposed to improve the current responses in the flux-weakening region, which includes the decoupling current controller and the voltage command compensator. The control performances are confirmed by several drive tests with respect to the prototype IPM motor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Agent-based meeting scheduling: A design and implementation (1995)

The Letter describes the design and implementation of a distributed meeting scheduling system in which each user has an intelligent agent in their computer desktop which is responsible for arranging meetings. Knowing the preferences and commitments of their user, the agents negotiate with one another to find the most acceptable meeting times.
Finding tribes (2007)

We present a family of algorithms to uncover tribes-groups of individuals who share unusual sequences of affiliations. While much work inferring community structure describes large-scale trends, we instead search for small groups of tightly linked individuals who behave anomalously with respect to those trends. We apply the algorithms to a large temporal and relational data set consisting of millions of employment records from the National Association of Securities Dealers. The resulting tribes contain individuals at higher risk for fraud, are homogenous with respect to risk scores, and are geographically mobile, all at significant levels compared to random or to other sets of individuals who share affiliations.
ChemInform Abstract: A Practical Synthesis of 4‐(3′,4′‐Dihydroxyphenyl)‐1,2,3,4‐ tetrahydroisoquinoline. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The epidemiology of tibial fractures (1995)

We performed an epidemiological analysis of 523 fractures treated in the Edinburgh Orthopaedic Trauma Unit over a three-year period using modern descriptive criteria. The fractures were defined in terms of their AO morphology and their degree of comminution, location and cause. Closed fractures were classified using the Tscherne grading system and open fractures according to the Gustilo classification. Further analysis of fractures caused by road-traffic accidents and football was carried out. The use of the AO classification allowed the common fracture patterns to be defined. Correlation of the classification systems showed an association between the AO morphological system and the Tscherne and Gustilo classifications. The relative rarity of severe tibial fractures is indicated and it is suggested that in smaller orthopaedic units the infrequency of these fractures has implications for training and the development of treatment protocols.
Differences of the Morphology of Subaxial Cervical Spine Endplates between Chinese and White Men and Women (2018)

<i>Objective.</i> The aim of this comparative anatomical study was to specifically investigate endplate morphology differences between Chinese and White men and women. <i>Materials and Methods.</i> Three-dimensional cervical endplate models were constructed using computed tomography imaging of 41 healthy Chinese and 24 White subjects. The morphologic measurements of cervical endplate included linear parameters (EPWu: upper endplate width; EPDu: upper endplate depth; EPWl: lower endplate width; and EPDl: lower endplate depth) and area parameters with a digital measuring system. <i>Results.</i> All linear parameters showed a constant increase from C3 to C7 except for EPDl in both the Chinese and the White subjects. An increase trend was observed on area parameters in both Chinese and White subjects. The ratio of EPWl/EPDl was smaller in Chinese females than in White females at C3, C4, and C6 levels (<i>P</i> < 0.05). The ratio of EPWl/EPDl was significantly different between the Chinese and White men at C4-5 levels (<i>P</i> < 0.05). <i>Conclusions.</i> Our data indicates that the morphology of subaxial cervical spine endplates between Chinese and White men and women is different in most of the linear and area parameters. This information could provide guidelines for the design of CDA implants and the improvement of surgical techniques.
Electrochemical reactions. Part 22. Intramolecular trapping of radical intermediates in the reduction of arylsulphones (1979)

The cyclic sulphone (1) gives a radical ion which is stable in dimethylformamide on the time scale of cyclic voltammetry and the ortho-substituted diarylsulphone (3) shows only irreversible electrochemical behaviour. Either sulphone at the potential of the first reduction wave gave products which indicate decomposition of the radical anion by cleavage of a carbon–sulphur bond to form an aryl radical and sulphinate ion. The isolated products result from intramolecular trapping of the aryl radical intermediate.
A Secreted Type of β1,6-N-Acetylglucosaminyltransferase V (GnT-V) Induces Tumor Angiogenesis without Mediation of Glycosylation (2002)

Angiogenesis is the first regulatory step of tumor progression. Herein, we report on some findings that show that beta1,6-N-acetylglucosaminyltransferase V (GnT-V) functions as an inducer of angiogenesis that has a novel and completely different function from the original function of glycosyltransferase. A secreted type of GnT-V protein itself promoted angiogenesis in vitro and in vivo at physiological concentrations. The highly basic domain of GnT-V induced the release of fibroblast growth factor-2 from heparan sulfate proteoglycan on the cell surface and/or extracellular matrix, leading to angiogenesis. These findings provide some novel information on the relationship between GnT-V and tumor metastasis. The inhibition of GnT-V secretion or its expression represents a novel potential strategy for the inhibition of tumor angiogenesis.