gebhart/patrepeval huggingface dataset:
On-line algorithms for the design of pipeline architectures (1979)

This paper presents a class of algorithms, On-Line Continued Sums/Products, which are amenable for the efficient implementation by a pipeline architecture. The implementation of these algorithms provides a simple and fast method for the evaluation of several of the elementary functions; i.e., addition, subtraction, multiplication, division, logarithm, exponentiation, sine, cosine, and tangent. In addition to possessing the expected properties necessary for the efficient implementation in a pipeline architecture, the On-Line Continued Sums/Products algorithms allow for the possibility of implementing a pipeline architecture which is dynamically reconfigurable and which can process variable precision operands.
The ordered assembly of tau is the gain‐of‐toxic function that causes human tauopathies (2016)

A pathological pathway leading from soluble to insoluble and filamentous tau underlies human tauopathies. This ordered assembly causes disease and is the gain-of-toxic function. It involves the transition from an intrinsically disordered monomer to a highly structured filament. Based on recent findings, one can divide the ordered assembly into propagation of pathology and neurodegeneration. Short tau fibrils constitute the major species of seed-competent tau in the brains of mice transgenic for human P301S tau. The molecular species of aggregated tau that are essential for neurodegeneration remain to be identified.
Service-Oriented Approach for Implementing an Extensible Content Management System (2008)

Enterprise content management systems deal with the management of business documents and related human workflow between organizations. Many of these systems are built as monolithic, stand-alone applications that lack the dynamicity support and are difficult to scale and interoperate with other enterprise systems. In order to tackle these issues, a service-oriented approach is introduced for the implementation of a distributed enterprise content management system that is composed from a number of common service components. The basic common service components are implemented according to the service component architecture (SCA), and consist of a content repository service, a document workflow service, a document search service, a notification service, a security service, an execution log service, and an integration service. In content repository service, a document meta-model is defined for managing, tracking and storage of business documents. In this paper, we first present the overall system architecture and detailed design of each service. We then illustrate how to assemble these services into higher-level composite services in order to provide document management functions for the enterprise application. Our implementation shows that our design is able to support on-demand document management services and scale-up in a large enterprise, without much development efforts.
Impact of file systems on SSD PE cycle consumption (2017)

SSDs (Solid State Disks) are next generation storage devices. SSD has two main parts, viz. NAND Flash and SSD Controller. The main headache for SSDs is `erase before write', because of which when data modification happens SSDs need to first erase present data from NAND blocks, which include other valid data also and then need to re-write whole content which causes Write amplification. The higher erase operations cause higher decrease in PE cycle count. If PE cycle count decreases at higher rate then SSD life span will decrease at higher rate. So to optimize SSD life span it is needed that data writing and modifying on SSD need to be optimized. This is job of FTL (Flash Translation layer) But FTL performs optimization on device side it will be beneficial if optimization is done on Host side i.e. via file systems. In this paper we are analyzing how different file systems cause impact on PE cycles of SSD.
Geographic information systems and disaggregate transportation modeling (1998)

BSTRACT Geographic information systems (GIS) have developed in response to a range of needs, and provide highly structured environments for working with particular classes of information. The environment and structure of a GIS is defined by its data model; the paper reviews the basic data models of GIS. The needs of discrete transportation modeling have led to a number of extensions of the basic data models. Further necessary extensions are identified. The paper ends with a discussion of appropriate strategies and future directions. GOODCHILD 1
The effect of fungicides on vesicular–arbuscular mycorrhizal symbiosis (1993)

This paper describes the effects of the fungicides Benlate, Aliette and Ridomil on plant growth and on mycorrhizal development in onion plants. An attempt was made to distinguish effects on plants from those on the fungus by making comparisons between mycorrhizal plants in the absence of added phosphorus and non-mycorrhizal equivalent size plants. Vital staining techniques were used to analyse the effects of the fungicides on the living fungus both within the root and in the soil. Benlate had no effect on shoot dry weight or root length of onion plants whereas a reduction in plant growth was observed following the application of Aliette or Ridomil, in comparison to control plants. Benlate had negative effects on the numbers of living internal hyphae, arbuscules, fungal-plant interface and living external hyphae in the soil. Aliette had no effect on the number of living intercellular hyphae and arbuscules. However, it markedly reduced the root length and the length of infected root per plant. These combined effects led to a reduction in the area of the interface between fungus and plant. The length of external hyphae per gram of soil was reduced following the application of Aliette, though not as severely as with Benlate. Ridomil had more complex effects on vesicular-arbuscular mycorrhizal symbiosis; treated plants showed a reduction in plant growth and also a reduction in all fungal parameters, namely the number of living intercellular hyphae, arbuscules and fungal-plant interface, the length of infected root and the development of external hyphae in the soil.
Influence of chain length of diol on the swelling behavior of citric acid based pH sensitive polymeric hydrogels: A green approach (2014)

ABSTRACT Synthesis of pH‐sensitive hydrogels of citric acid with varying diol units viz ., 1,2 Ethane diol, 1,4 butane diol, and 1,6 hexane diol along with methacrylic acid towards the solventless green approach. The formations of the hydrogels were identified using FTIR spectroscopy. Thermal characterization (thermo gravimetric analysis, differential thermal analysis (DTA), and differential scanning calorimetry) and morphology of the synthesized hydrogels have been investigated. Swelling studies of hydrogels in various pH ranging from 4.0 to 10.0 have been investigated. The results of the swelling studies implied that percentage of swelling comparatively higher at neutral pH (7.4) than at acidic and alkaline pH. The inverse relationship was noticed, where ascending the diol units of hydrogel in swelling equilibrium. The hydrogels with the increasing chain length show a noticeable pH sensitivity and which could be considered as smart hydrogel. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41403.
Borehole-radar exploration in a coal seam (1977)

Abstract The experimental use of "geologic radar" to explore through coal from mined passages underground has already been reported elsewhere (Cook, 1973, 1974). Low-resolution borehole radar work in salt, a much more favorable medium, has also been reported (Holzer et al., 1972). The purpose of this paper is to report the first known results of borehole radar tests in coal. The exploration of coal seams via boreholes from the surface is potentially a technique of great practical importance. The borehole experiment was performed in conjunction with a month-long program of radar tests in Australian collieries and quarries performed under the sponsorship of the third ICOGEO and supported by several Australian mining and research organizations. A report on that program is expected to appear in the Bulletin of the Australian Society of Exploration Geophysicists some time during 1977.
An M-ary KMP classifier for multi-aspect target classification (2004)

The kernel matching pursuit (KMP) algorithm is re-formulated in the framework of the theory of optimal experiments, using a weighted sum of squared errors as the loss function, and it is extended to the case of M-ary target classification and kernel optimization. The M-ary KMP classifier is applied to the multi-aspect classification of moving targets based on high-range resolution (HRR) radar signatures, for which the target-sensor orientations are assumed approximately known. A multi-aspect processing method is presented based on the use of the estimates of target-sensor orientation angles. The KMP classification results for ten MSTAR targets are presented, with a comparison to corresponding results using the relevance vector machine (RVM).
Effect on the speech reception threshold in noise of the recovery time of the compressor in the high-frequency channel of a two-channel aid. (1993)

This paper describes two experiments in a series evaluating and optimising a hearing aid incorporating two forms of automatic gain control (AGC). The first form is a front-end AGC which is normally slow acting and which compensates for variations in the overall level of speech from one situation to another. The second form of AGC follows the front-end AGC. The signal is split into two frequency bands, and fast-acting AGC is applied in the upper band only. The bands are then recombined. The two experiments described here were aimed at determining the optimum value of the recovery time of the AGC in the high-frequency channel. Speech reception thresholds (SRTs) were measured in the presence of speech-shaped noise as a function of the recovery time, for subjects with mild-to-moderate sensorineural loss. In the first experiment the recovery time was varied over the range 10-80 ms. SRTs tended to be lowest (best) at the shorter recovery times but the effects were small. In the second experiment, the recovery time was varied over the range 5-320 ms. In this case, there was a clear trend for SRTs to increase with increasing recovery time. A recovery time of about 20 ms appears to be optimal.
Translocation of ATP into the lumen of rough endoplasmic reticulum-derived vesicles and its binding to luminal proteins including BiP (GRP 78) and GRP 94. (1992)

Rat liver and canine pancreas rough endoplasmic reticulum-derived vesicles, which were sealed and of the same topographical orientation as in vivo, were used in a system in vitro to demonstrate translocation of ATP into their lumen. Translocation of ATP is saturable (apparent Km: 3-4 microM and Vmax: 3-7 pmol/min/mg of protein) and protein mediated because treatment of intact vesicles with Pronase, N-ethylmaleimide, or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid inhibit transport. The entire ATP molecule is being translocated; this was shown by high performance liquid chromatography analysis and the use of a nonhydrolyzable analog. Control experiments rule out that translocation of ATP attributed to rough endoplasmic reticulum-derived vesicles is due to contamination by mitochondria and Golgi vesicles. Following translocation of ATP into the lumen of the vesicles, binding to luminal proteins including BiP (immunoglobulin heavy chain-binding protein-glucose-regulated protein 78) and glucose-regulated protein 94 was observed. This binding appeared to be specific because similar experiments with GTP were negative. These studies strongly suggest that translocation of ATP into the rough endoplasmic reticulum lumen may serve as a mechanism for making ATP available in proposed energy requiring reactions within the lumen.
Cadaver study challenges brain stimulation methods (2016)

Unusual test of transcranial stimulation shows that little electrical current penetrates the skull.
Structure and Absolute Stereochemistry of Salvimirzacolide, a New Sesterterpene from <i>Salvia mirzayanii</i> (1998)

A new sesterterpene, salvimirzacolide (1), was isolated from the aerial parts of Salvia mirzayanii and its structure established by X-ray diffraction analysis. Full assignments of 1H- and 13C-NMR spectral data of salvimirzacolide are presented.
Titanium Complex-Catalyzed Borohydride Reduction of Azobenzenes (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTitanium Complex-Catalyzed Borohydride Reduction of AzobenzenesPeter Dosa, Ian Kronish, Jeremy McCallum, Jeffrey Schwartz, and Michael C. BardenView Author Information Department of Chemistry, Princeton University, Princeton, New Jersey 08544-1009 Cite this: J. Org. Chem. 1996, 61, 15, 4886–4887Publication Date (Web):July 26, 1996Publication History Received13 May 1996Published online26 July 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo960871khttps://doi.org/10.1021/jo960871krapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views479Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amines,Anions,Azobenzene,Electrochemical reduction,Redox reactions Get e-Alerts
Altropane, a SPECT or PET imaging probe for dopamine neurons: I. dopamine transporter binding in primate brain (1998)

Increasing evidence suggests that the dopamine transporter is an important marker for physiological and pathological changes in dopamine neurons. Potent dopamine transport inhibitors of the phenyltropane series (e.g., WIN 35,428 or CFT) are particularly suitable for PET (positron emission tomography) or SPECT (single photon emission computed tomography) imaging of the dopamine transporter in living brain. We investigated whether altropane, an N-iodoallyl analog of WIN 35,428 (IACFT:E-N-iodoallyl-2 -carbomethoxy-3beta-(4-fluorophenyl)tropane), displayed in vitro properties suitable for evaluation as a SPECT imaging agent. In brain striatum of cynomolgus monkey (Macaca fascicularis), the unlabeled E-isomer (IC50: 6.62 +/- 0.78 nM) was more potent than the Z-isomer (IC50: 52.6 +/- 0.3 nM) and displayed a relatively high dopamine:serotonin transporter selectivity (28-fold). In radiolabeled form, [125I]altropane bound to sites in the striatum with a single high affinity (KD: 5.33 +/- 0.55 nM) and with a site density (BMAX: 301 pmol/g original wet tissue weight) that was within the density range reported previously for the dopamine transporter in striatum. Drugs inhibited [125I]altropane binding with a rank order of potency that corresponded closely to their potencies for inhibiting [3H]WIN 35,428 binding (r2: 0.99; P < 0.0001) to the blocking dopamine transport. The favorable binding properties of altropane, together with its rapid entry into primate brain and highly localized distribution in dopamine-rich brain regions, suggest it is a suitable iodinated probe for monitoring the dopamine transporter in vitro and in vivo by SPECT or PET imaging.
An Integrative Approach to the Identification of Arabidopsis and Rice Genes Involved in Xylan and Secondary Wall Development (2010)

Xylans constitute the major non-cellulosic component of plant biomass. Xylan biosynthesis is particularly pronounced in cells with secondary walls, implying that the synthesis network consists of a set of highly expressed genes in such cells. To improve the understanding of xylan biosynthesis, we performed a comparative analysis of co-expression networks between Arabidopsis and rice as reference species with different wall types. Many co-expressed genes were represented by orthologs in both species, which implies common biological features, while some gene families were only found in one of the species, and therefore likely to be related to differences in their cell walls. To predict the subcellular location of the identified proteins, we developed a new method, PFANTOM (plant protein family information-based predictor for endomembrane), which was shown to perform better for proteins in the endomembrane system than other available prediction methods. Based on the combined approach of co-expression and predicted cellular localization, we propose a model for Arabidopsis and rice xylan synthesis in the Golgi apparatus and signaling from plasma membrane to nucleus for secondary cell wall differentiation. As an experimental validation of the model, we show that an Arabidopsis mutant in the PGSIP1 gene encoding one of the Golgi localized candidate proteins has a highly decreased content of glucuronic acid in secondary cell walls and substantially reduced xylan glucuronosyltransferase activity.
Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. (1997)

We have investigated the expression of cyclin D1 in adenocarcinoma of the pancreas and the relevance of cyclin D1 expression to clinical outcome. In comparison to normal pancreas, Southern blot analyses revealed amplification of the cyclin D1 coding gene in 25% of the cases, whereas with reverse transcription-PCR, overexpression of mRNA was observed in 82% of the examined tissues. Immunohistochemically, we could demonstrate nuclear overexpression in tumor cells in 68.4%, and this protein accumulation correlated significantly with poor prognosis [median survival, 18.1 versus 10.5 months; P < 0.01 (chi2 test)].
Assessing the suitability of the NGMP multi-core processor in the space domain (2012)

Multi-core processors are increasingly being considered as a means to provide the performance required by future safety-critical embedded systems. In this line, Aeroflex Gaisler has developed, in conjunction with the European Space Agency, the NGMP, a quad-core processor to be used in the future space missions of the Agency. Unfortunately, the use of multi-core processors in industrial domains is not straightforward since it poses various challenges on the timing behavior of the system. This is mainly due to the interferences tasks suffer when accessing hardware shared resources and which can affect their WCET. Although the effect of inter-task interferences in multi-core shared resources on real-time applications has received attention from academia, most of the solutions proposed require hardware changes. The lack of quantitative studies of the slowdown on applications' performance caused by inter-task interferences on real COTS multi-core processors, limit their use by industry.
The Management of the Atlanto-Occipital and Atlanto-Axial Joint Pain (2000)

Headaches secondary to atlanto-occipital and atlanto-axial joints are often associated with suboccipital pain and aggravated by lateral rotation of the cervical spine and/or flexion or extension of the cervical spine. They are frequently under-diagnosed using traditional radiological evaluation including plain X-rays, computerized tomographic scan, and magnetic resonance imaging. While the natural history of most acute atlanto-occipital and atlanto-axial joint inflammation is resolution over a 2-to-4-week period with conservative management, however, when chronicity sets in, resolution is difficult to achieve using conservative measures, and interventional pain management procedures may be indicated. This review will describe the anatomy of the upper cervical spine, clinical presentation of atlanto-occipital and atlanto-axial joint involvement, and various modalities of treatment, including conservative and interventional modalities.
Ashimycins A and B, new streptomycin analogues. (1989)

Detailed analysis of the fermentation broth of Streptomyces griseus strain FT3-4 resulted in the identification of two new streptomycin analogues named ashimycins A and B. Their structures have been determined by NMR spectral analysis and chemical degradations.
1.8 mΩ·cm<sup>2</sup>vertical GaN-based trench metal–oxide–semiconductor field-effect transistors on a free-standing GaN substrate for 1.2-kV-class operation (2015)

In this paper, we report on 1.2-kV-class vertical GaN-based trench metal–oxide–semiconductor field-effect transistors (MOSFETs) on a free-standing GaN substrate with a low specific on-resistance. A redesigned epitaxial layer structure following our previous work with a regular hexagonal trench gate layout enables us to reduce the specific on-resistance to as low as 1.8 mΩ·cm2 while obtaining a sufficient blocking voltage for 1.2-kV-class operation. Normally-off operation with a threshold voltage of 3.5 V is also demonstrated. To the best of our knowledge, this is the first report on vertical GaN-based MOSFETs with a specific on-resistance of less than 2 mΩ·cm2.
A translational enhancer derived from tobacco mosaic virus is functionally equivalent to a Shine-Dalgarno sequence. (1989)

When present at the 5' end of mRNAs, the untranslated leader sequence (omega) of tobacco mosaic virus RNA significantly enhances translation in eukaryotes and prokaryotes. We have tested a deletion derivative of the omega sequence, omega delta 3, for its enhancing ability on gene constructs in which the ribosomal binding site was either present or deleted, in several Gram-negative bacterial species including Escherichia coli, Agrobacterium tumefaciens, Xanthomonas campestris pv. vitians, Erwinia amylovora, and Salmonella typhimurium. In vivo production of chloramphenicol acetyltransferase from a gene construct lacking its native ribosomal binding site was enhanced 40- to 120-fold by the presence of omega delta 3. Similar levels of enhancement (30- to 240-fold) were observed when the gene encoding beta-glucuronidase was tested. With a chloramphenicol acetyltransferase construct containing a ribosomal binding site, enhancement was markedly less, between 1- and 3.8-fold. Omega delta 3 appeared to enhance translation independent of its position upstream of the AUG codon used for initiation.
Fractal Surfaces of Proteins (1985)

Fractal surfaces can be used to characterize the roughness or irregularity of protein surfaces. The degree of irregularity of a surface may be described by the fractal dimension D. For protein surfaces defined with probes in the range of 1.0 to 3.5 angstroms in radius, D is approximately 2.4 or intermediate between the value for a completely smooth surface (D = 2) and that for a completely space-filling surface (D = 3). Individual regions of proteins show considerable variation in D. These variations may be related to structural features such as active sites and subunit interfaces, suggesting that surface texture may be a factor influencing molecular interactions.