The Absorption of Calcium Carbonate (1967)

Article1 May 1967The Absorption of Calcium CarbonatePETER IVANOVICH, M.D., HAROLD FELLOWS, B.A., CLAYTON RICH, M.D.PETER IVANOVICH, M.D., HAROLD FELLOWS, B.A., CLAYTON RICH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-917 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough calcium carbonate (CaCO3) is widely used in the treatment of peptic ulcer disease and is freely available on the open market, relatively little information about its absorption is available. It has often been assumed that, because CaCO3is insoluble in water, calcium given in this form is not appreciably absorbed. However, significant hypercalcemia and alkalosis are observed occasionally among persons treated with CaCO3(1,2), and in a controlled study, hypercalcemia was found to be a frequent complication of this form of treatment (3). Furthermore, some patients treated with milk and alkali develop irreversible renal damage and calcifications of the...References1. COPE CL: Base changes in the alkalosis produced in the treatment of gastric ulcer with alkali. Clin. Sci. 2: 287, 1936. Google Scholar2. PUNSARSOMER ST: The milk-alkali syndrome. A report of three illustrative cases and a review of the literature. Acta Med. Scand. 173: 435, 1963. CrossrefMedlineGoogle Scholar3. MCMILLANFREEMAN DERB: The milk alkali syndrome: a study of the acute disorder with comments on the development of the chronic condition. Medicine (Balt.) 44: 485, 1965. CrossrefMedlineGoogle Scholar4. BURNETTCOMMONSALBRIGHTHOWARD CHRRFJE: Hypercalcemia without hypercalcuria or hypophosphatemia, calcinosis and renal insufficiency: a syndrome following prolonged intake of milk and alkali. New Eng. J. Med. 240: 787, 1949. CrossrefMedlineGoogle Scholar5. COPEBARNESCASTLEMANMUELLERROTH OBABGCSI: Vicissitudes of parathyroid surgery: trials of diagnosis and management in 51 patients with a variety of disorders. Ann. Surg. 154: 491, 1961. CrossrefMedlineGoogle Scholar6. DEGRAZIAIVANOVICHFELLOWSRICH JAPHC: A double isotope method for measurement of intestinal absorption of calcium in man. J. Lab. Clin. Med. 66: 822, 1965. MedlineGoogle Scholar7. DEGRAZIARICH JAC: Studies of intestinal absorption of calcium-45 in man. Metabolism 13: 650, 1964. CrossrefMedlineGoogle Scholar8. OTTENJANNWIDMAIERDEMLING RFL: Hypercalcämie und magensekretion. Klin. Wschr. 41: 717, 1963. CrossrefMedlineGoogle Scholar9. HEANEYWHEDON RPG: Radiocalcium studies of bone formation rate in human metabolic bone disease. J. Clin. Endocr. 18: 1246, 1958. CrossrefGoogle Scholar10. SKILLMANHEANEY TGRP: Endogenous intestinal calcium secretion (abstract). J. Lab. Clin. Med. 60: 1018, 1962. Google Scholar11. THOMASBIRDLEWIS WCEDAM: Effects of alkaline salt on distribution of Ca47 in hypoparathyroidism(abstract). Clin. Res. 14: 102, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the University of Washington School of Medicine and the Radioisotope Service, Veterans Administration Hospital, Seattle, Wash.This study was supported in part by grants AM 09096 and AM 04701, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Clayton Rich, M.D., Veterans Administration Hospital, 4435 Beacon Ave. South, Seattle, Wash. 98108. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLong-term use of proton pump inhibitors adversely affects minerals and vitamin metabolism, bone turnover, bone mass, and bone strengthPolypharmacy and Malnutrition Management of Elderly Perioperative Patients with Cancer: A Systematic ReviewIs drug consumption correlated with benign paroxysmal positional vertigo (BPPV) recurrence?Lansoprazole inhibits the cysteine protease legumain by binding to the active siteRelevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective studyThe Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological AssociationMicronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A reviewRefractory hypocalcemia and hypomagnesemia associated with the use of an oral proton-pump inhibitor in a patient with hypoparathyroidismThe Therapeutic Effectiveness of the Coadministration of Weekly Risedronate and Proton Pump Inhibitor in Osteoporosis TreatmentThe role of the gastrointestinal tract in calcium homeostasis and bone remodelingThe effects of risedronate administered in combination with a proton pump inhibitor for the treatment of osteoporosisGastric Acid, Calcium Absorption, and Their Impact on Bone HealthChronic Proton Pump Inihibitor Therapy and Calcium MetabolismEffect of gastric acid suppression with pantoprazole on the efficacy of calcium carbonate as a phosphate binder in haemodialysis patientsRecent Safety Concerns With Proton Pump InhibitorsConsiderations for the Use of Proton-Pump Inhibitors in Older AdultsMechanism of drug interaction between a Kampo medicine, byakkokaninjinto, and tetracycline in ratsProton Pump Inhibitor use in Hospitalized Patients: Is Overutilization Becoming a Problem?Calcium Citrate and Vitamin D in the Treatment of OsteoporosisAdverse Effects of Long-Term Proton Pump Inhibitor TherapyUse of proton pump inhibitors and risk of hip/femur fracture: a population-based case-control studyCalcium Citrate and Vitamin D in the Treatment of OsteoporosisMilk Alkali and Hydrochlorothiazide: A Case ReportProton pump inhibitor-associated pneumonia: Not a breath of fresh air after all?Use of proton pump inhibitors increased the risk of hip fracture: a population-based case-control studySafety of Proton Pump Inhibitor ExposureHypochlorhydric stomach: a risk condition for calcium malabsorption and osteoporosis?Proton pump inhibitors, osteoporosis, and osteoporosis-related fracturesLong-term Proton Pump Inhibitor Therapy and Risk of Hip FractureRole of Proton Pump Inhibitors in Calcium Absorption, Bone Resorption, and Risk of Hip FractureThe presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral densityProtein intake and calcium absorption – Potential role of the calcium sensor receptorBiodisponibilidade do cálcio dietéticoMilk-Alkali Syndrome: A Historical Review and Description of the Modern Version of the SyndromeSevere hypercalcemia after transition from calcium carbonate to calcium citrate in an elderly woman treated with ergocalciferol 50,000 IU per dayCalcium Carbonate Toxicity: The Updated Milk-Alkali Syndrome; Report of 3 Cases and Review of the LiteratureThe effect of pH, time and dietary source of cadmium on the bioaccessibility and adsorption of cadmium to/from lettuce (Lactuca sativa L. cv. Ostinata)Alteration in digestion and absorption of nutrients during profound acid suppressionExtracts of ECL-cell granules/vesicles and of isolated ECL cells from rat oxyntic mucosa evoke a Ca2+ second messenger response in osteoblastic cellsRole of Calcium Carbonate Administration Timing in Relation to Food Intake on Its Efficiency in Controlling Hyperphosphatemia in Patients on Maintenance DialysisPathophysiology of Calcium, Phosphate, and Magnesium AbsorptionDietary Fructooligosaccharides Prevent Osteopenia After Gastrectomy in RatsIntestinal calcium absorption from different calcium preparations: Influence of anion and solubilityHypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans.Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle sizeStructure of Calvaria after Gastrectomy: An Experimental Study in the RatA Review of Calcium PreparationsBody size, estrogen use and thiazide diuretic use affect 5-year radial bone loss in postmenopausal womenEffect of Multiple Staggered Doses of Calcium on the Bioavailability of CiprofloxacinHypochlorhydria does not inhibit zinc absorption in the ratGastric Acidity, Atrophic Gastritis, and Calcium Absorption*Gastric Acid in VertebratesMineral needs of the elderly: Developing a research agenda for the 1990sIn vitro dissolution of calcium carbonate preparationsThe solubility of calcium from antacid tablets, calcium supplements and fortified food productsEffect of staggered dose of calcium on the bioavailability of ciprofloxacinComparative absorption of calcium from carbonate tablets, lactogluconate/carbonate effervescent tablet, and chloride solutionInhibition of gastric acid secretion in the rat by high calciumNutrients and OsteoporosisThe Pharmacology of Antiulcer DrugsPhosphate-Binding Effects of Sucralfate in Patients With Chronic Renal FailureCalciumGastrointestinal Absorption of Calcium from Milk and Calcium SaltsTHE ACUTE BIOCHEMICAL EFFECTS OF FOUR PROPRIETARY CALCIUM PREPARATIONSImplications of Gastric Atrophy for Vitamin and Mineral NutritureCorrelates of forearm bone mass among women during maximal bone mineralizationCalcium Absorption and AchlorhydriaHazards of Treating Osteoporosis and Hypertension Concurrently with Calcium, Vitamin D, and Distal DiureticsRelation between gastric secretion of acid and urinary excretion of calcium after oral supplements of calciumParathyroid Physiology and Primary HyperparathyroidismAntacids and Anticholinergic DrugsARMAND LITTMAN, M.D., F.A.C.P., BRIAN H. PINE, M.D.Antacid TherapyEffect of single large doses of oral calcium on serum calcium levels in the young and the elderlyHYPERCALCÆMIA AFTER ORAL CALCIUM-CARBONATE THERAPY IN PATIENTS ON CHRONIC HÆMODIALYSISAcid Secretion after Calcium Carbonate in Patients with Duodenal UlcerIsotopic determination of intestinal calcium absorption in normal subjectsPeptic Ulcer: A Review of the Recent Literature on Various Clinical Aspects 1 May 1967Volume 66, Issue 5Page: 917-923KeywordsAttentionCalciumCarbonatesHospital medicineHypercalcemiaMedical servicesMilkPeptic ulcers Issue Published: 1 May 1967 PDF downloadLoading ...