gebhart/patrepeval huggingface dataset:
Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events (2008)

Toll-like receptors (TLRs) are pattern recognition receptors of innate immunity. TLRs initiate inflammatory pathways that may exacerbate chronic inflammatory diseases like atherosclerosis. En face laser scanning confocal microscopy (LSCM) of isolated aortic segments revealed the distribution of intimal TLR2 expression and the atheroprotective outcomes resulting from a TLR2 deficiency. TLR2 expression was restricted to endothelial cells in regions of disturbed blood flow, such as the lesser curvature region, in atherosclerosis-prone, low-density lipoprotein receptor-deficient (LDLr(-/-)) mice. Diet-induced hyperlipidemia in LDLr(-/-) mice increased this regional endothelial TLR2 expression. Bone marrow (BM) reconstitution of LDLr(-/-) and LDLr(-/-)TLR2(-/-) mice created chimeric mice with green fluorescent protein (GFP) expression in BM-derived cells (BMGFP(+)). Lesser curvature BMGFP(+) leukocyte accumulation, lipid accumulation, foam cell generation and endothelial cell injury were all increased by hyperlipidemia, whereas hyperlipidemic double mutant BMGFP(+)LDLr(-/-)TLR2(-/-) mice had reduced BMGFP(+) leukocyte accumulation, lipid accumulation, foam cells, and endothelial cell injury. This is the first report of in vivo site-specific expression of endothelial cell TLR2. Expression of this receptor on endothelial cells contributed to early atherosclerotic processes in lesion-prone areas of the mouse aorta.
Creating conversational interfaces for children (2002)

Creating conversational interfaces for children is challenging in several respects. These include acoustic modeling for automatic speech recognition (ASR), language and dialog modeling, and multimodal-multimedia user interface design. First, issues in ASR of children's speech are introduced by an analysis of developmental changes in the spectral and temporal characteristics of the speech signal using data obtained from 456 children, ages five to 18 years. Acoustic modeling adaptation and vocal tract normalization algorithms that yielded state-of-the-art ASR performance on children's speech are described. Second, an experiment designed to better understand how children interact with machines using spoken language is described. Realistic conversational multimedia interaction data were obtained from 160 children who played a voice-activated computer game in a Wizard of Oz (WoZ) scenario. Results of using these data in developing novel language and dialog models as well as in a unified maximum likelihood framework for acoustic decoding in ASR and semantic classification for spoken language understanding are described. Leveraging the lessons learned from the WoZ study and a concurrent user experience evaluation, a multimedia personal agent prototype for children was designed. Details of the architecture and application details are described. Informal evaluation by children was found positive especially for the animated agent and the speech interface.
An Effective Framework for Question Answering over Freebase via Reconstructing Natural Sequences (2017)

Question answering over knowledge bases has rapidly developed with the continuous expansion of resources. However, how to match the natural language question to the structured answer entities in the knowledge bases remains a major challenge. In this paper, we propose an effective framework that bridges the gap between the given question and the answer entities, by reconstructing the intermediate natural sequences on the basis of the entities and relations in knowledge bases. The intuitive idea is that these intermediate sequences may encode rich semantic information that can identify the candidate answer entities. Experimental evaluation is conducted on a benchmark dataset WebQuestions. Results demonstrate the effectiveness of our proposed framework, i.e., it outperforms state-of-the-art models by up to 6.8% in terms of F1 score.
Design of Chinese HPSG Framework for Data-Driven Parsing (2009)

Data-driven parsing has been a main method for analyzing natural languages. We aim at exploring a data-driven Chinese parser, by basing it on Head-driven Phrase Structure Grammar (HPSG). Unlike for English, there is still no available Chinese HPSG framework. As the first step of our work, we design a Chinese HPSG framework, which can be used as the basis for a practical parser. In this paper, 1) we present a Chinese syntactic structure system and 2) we design a primary Chinese HPSG framework.
The interactions between nisoldipine and two beta‐adrenoceptor antagonists‐atenolol and propranolol. (1991)

1. The interactions between the dihydropyridine calcium antagonist nisoldipine and two beta-adrenoceptor blocker drugs (atenolol and propranolol) were investigated in two groups of healthy normotensive subjects. 2. The steady state plasma concentrations of both beta-adrenoceptor blockers were significantly altered by the addition of nisoldipine: for propranolol there were significant increases in Cmax, by about 50%, and in AUC by about 30% and for atenolol there was a significant increase in Cmax, by about 20%. 3. The addition of nisoldipine was also associated with significant changes in apparent liver blood flow (measured by indocyanine green clearance) from 1.4 to 2.4 l min-1 in the atenolol group and from 1.3 to 2.3 l min-1 in the propranolol group. 4. Both nisoldipine-beta-adrenoceptor blocker combinations were associated with small enhanced blood pressure reductions e.g. from 104/60 with atenolol alone to 98/50 mm Hg with the combination but there was no alteration to the extent of beta-adrenoceptor blockade (as assessed by bicycle ergometry). 5. This pharmacodynamic profile in healthy normotensives is consistent with the known therapeutic efficacy of such combination treatments in patients with hypertension and angina. 6. It is suggested that there is a pharmacokinetic component to the efficacy of this type of combination, perhaps reflecting vasodilator-induced changes in drug absorption and/or hepatic extraction.
Selective implantation and growth in rats and mice of experimental liver metastasis in acinar zone one. (1989)

The functional zonation of liver tissue provides a framework for studying the implantation and growth of metastatic colonies within given zones of the hepatic acini. A very exact method for calibrating the position of metastatic foci in the hepatic acini was made possible by using the succinate-dehydrogenase reaction, which reveals the functional differences of the acinar zones. In mouse livers, metastasis was induced by intrasplenic injection of both high and low metastatic-capacity B16 melanoma and Lewis lung carcinoma cells. In rats, liver metastasis resulting from rhabdomyosarcoma was studied by injecting these cells into the s.c. tissue. All cases of metastasis occurred in hepatic acinar zone 1, and no significant differences were detected resulting from the type of tumor, its metastatic potential, or the procedure used for obtaining the metastasis. In subsequent experiments, metastasis was induced after first altering the zonal distribution of the hepatic extracellular matrix; distribution of the sinusoidal macrophages; and the sinusoidal diameter. However, even under these conditions, metastasis continues to occur exclusively in hepatic acinar zone 1. Thus, metastatic predilection for hepatic acinar zone 1 cannot be explained solely in terms of hemodynamic causes or the influence of extracellular matrix. Although it may still turn out that these elements play some secondary role in the phenomenon, our research points to the sinusoidal endothelial cells as a factor directly responsible for metastatic predilection for zone 1.
Effects of a Novel Long Noncoding RNA, lncUSMycN, on N-Myc Expression and Neuroblastoma Progression (2014)

Our data demonstrate the important roles of lncUSMycN and NonO in regulating N-Myc expression and neuroblastoma oncogenesis and provide the first evidence that amplification of long noncoding RNA genes can contribute to tumorigenesis.
Examining BPEL’s Compensation Construct (2005)

Abstract. This paper gives a short description of some features of long-running transactions, as well as the language BPEL and its particular implementation of the compensation concept. Two examples are used to illustrate the application of BPEL’s compensation construct. These examples, and reference to a structural operational semantics developed elsewhere, are used to help support an argument for the need of a more general implementation of compensation. 1
Synthesis and Properties of High-Valent Organouranium Complexes Containing Terminal Organoimido and Oxo Functional Groups. A New Class of Organo-f-Element Complexes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Properties of High-Valent Organouranium Complexes Containing Terminal Organoimido and Oxo Functional Groups. A New Class of Organo-f-Element ComplexesDavid S. J. Arney and Carol J. BurnsCite this: J. Am. Chem. Soc. 1995, 117, 37, 9448–9460Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ja00142a011https://doi.org/10.1021/ja00142a011research-articleACS PublicationsRequest reuse permissionsArticle Views1250Altmetric-Citations217LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory / Antioxidant Activities (2004)

Several natural products with a coumarinic moiety have been reported to have multiple biological activities. It is to be expected that, in a similar way to isomeric flavonoids, coumarins might affect the formation and scavenging of reactive oxygen species (ROS) and influence processes involving free radical-mediated injury. Coumarin can reduce tissue edema and inflammation. Moreover coumarin and its 7-hydroxy-derivative inhibit prostaglandin biosynthesis, which involves fatty acid hydroperoxy intermediates. Natural products like esculetin, fraxetin, daphnetin and other related coumarin derivatives are recognised as inhibitors not only of the lipoxygenase and cycloxygenase enzymic systems, but also of the neutrophil-dependent superoxide anion generation. Due to the unquestionable importance of coumarin derivatives considerable efforts have been made by several investigators, to prepare new compounds bearing single substituents, or more complicated systems, including heterocyclic rings mainly at 3-, 4- and/or 7-positions. In this review we shall deal with naturally occurring or synthetically derived coumarin derivatives, which possess anti-inflammatory as well as antioxidant activities.
Multinuclear NMR as a tool for studying local order and dynamics in CH<sub>3</sub>NH<sub>3</sub>PbX<sub>3</sub>(X = Cl, Br, I) hybrid perovskites (2016)

We report on <sup>207</sup>Pb, <sup>79</sup>Br, <sup>14</sup>N, <sup>1</sup>H, <sup>13</sup>C and <sup>2</sup>H NMR experiments for studying the local order and dynamics in hybrid perovskite lattices. <sup>207</sup>Pb NMR experiments conducted at room temperature on a series of MAPbX<sub>3</sub> compounds (MA = CH<sub>3</sub>NH<sub>3</sub><sup>+</sup>; X = Cl, Br and I) showed that the isotropic <sup>207</sup>Pb NMR shift is strongly dependent on the nature of the halogen ions. Therefore <sup>207</sup>Pb NMR appears to be a very promising tool for the characterisation of local order in mixed halogen hybrid perovskites. <sup>207</sup>Pb NMR on MAPbBr<sub>2</sub>I served as a proof of concept. Proton, <sup>13</sup>C and <sup>14</sup>N NMR experiments confirmed the results previously reported in the literature. Low temperature deuterium NMR measurements, down to 25 K, were carried out to investigate the structural phase transitions of MAPbBr<sub>3</sub>. Spectral lineshapes allow following the successive phase transitions of MAPbBr<sub>3</sub>. Finally, quadrupolar NMR lineshapes recorded in the orthorhombic phase were compared with simulated spectra, using DFT calculated electric field gradients (EFG). Computed data do not take into account any temperature effect. Thus, the discrepancy between the calculated and experimental EFG evidences the fact that MA cations are still subject to significant dynamics, even at 25 K.
Cloud-native Service Function Chaining for 5G based on Network Service Mesh (2020)

5G will provide a flexible and programmable infrastructure, allowing different networks to share the same access network. A way to respond to the diverse service requirements of 5G while reducing both CAPEX and OPEX is to adopt cloud-native architectures. In this context, micro-services software design, the corner stone of cloud-native architecture, seems to be ideal for 5G. However, despite its several advantages, micro-services raise new challenges which slow its adoption down in the NFV ecosystem. Indeed, steering the expected 5G traffic between cloud-native network function is extremely challenging and is still under-investigated. In this paper, we address the service function chaining (SFC) in micro-service based network function virtualization (NFV) ecosystem from the view of the traffic steering. Specifically, we design and implement a cloud-native SFC framework offering efficient traffic steering mechanisms while considering the network state of the underlying NFV infrastructure. In this context, an optimized network-aware load balancing strategy is proposed. Based on extensive experiments, the results obtained show that our strategy achieved good results in terms of i) end-to-end latency and ii) deployment time.
Antiferromagnetic domain switching in Cr<sub>2</sub>O<sub>3</sub> (1966)

Controlled antiferromagnetic domain reversals have been observed in single crystal Cr <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> . Switching between substantially single domain states has been achieved with the simultaneous impression of electric and magnetic fields of approximately 10 kV/cm and 5 kOe, respectively. The switching energy is closely proportional to the product of the two switching fields, in agreement with theory. The switched domain state was stable when the applied energy was reduced and even when reversed in sign, until its value reached the same order of magnitude as the first threshold energy, at which point the domain state switched back. Several widely different switching thresholds have been detected for switching in each direction in the crystal. The magnitudes of all the threshold energies increase rapidly but at different rates with decrease in temperature. The speed of antiferromagnetic domain reversal in this crystal has been measured. Switching behavior is discussed in terms of seed-domains and pinning centers distributed throughout the crystal.
Web Search Trends of Implementing the Patient Autonomy Act in Taiwan (2020)

Even though the Patient Autonomy Act was first published three years before its implementation, the related search volume only increased on the eve of its implementation. Therefore, whether the three-year buffer between its publication and implementation was necessary requires further investigation.
No-scalpel vasectomy: a technique for family physicians. (1992)

Family physicians frequently perform outpatient vasectomies. A new approach to exposing the vas deferens, called the no-scalpel vasectomy, results in fewer complications and, the authors believe, improved patient acceptance. This technique, which calls for two specialized instruments, is described, along with patient selection and education issues, vasal occlusion techniques and post-vasectomy follow-up.
SiZer for Exploration of Structures in Curves (1999)

Abstract In the use of smoothing methods in data analysis, an important question is which observed features are “really there,” as opposed to being spurious sampling artifacts. An approach is described based on scale-space ideas originally developed in the computer vision literature. Assessment of Significant ZERo crossings of derivatives results in the SiZer map, a graphical device for display of significance of features with respect to both location and scale. Here “scale” means “level of resolution”; that is, “bandwidth.”
The Effect of Microaerosolized Hydrogen Peroxide on Bacterial and Viral Poultry Pathogens (1994)

The effect of microaerosolized H2O2 on bacterial and viral poultry pathogens was investigated. Bacterial cultures and viruses were dried on sterile glass Petri dishes and subjected to direct and indirect 5% (H2O2) microaerosol mist. In the trials using Escherichia coli and Staphylococcus aureus, there was complete inactivation following exposure to H2O2. Using Salmonella typhimurium, indirect exposure resulted in only partial inactivation whereas direct exposure to H2O2 gave complete inactivation. For the viruses studied, 5% H2O2 microaerosol mist completely inactivated infectious laryngotracheitis virus. Newcastle disease virus, infectious bronchitis virus, and avian influenza virus showed reduced infectivity but were not completely inactivated. Avian reovirus susceptibility varied with the method of exposure and infectious bursal disease virus was highly resistant. The use of 10% H2O2 mist, however, resulted in total inactivation of infectious bursal disease virus. The effect of 10% H2O2 on equipment and selected materials representative of a hatcher or poultry house was investigated. A solar cell calculator, a thermostat containing a microswitch, and samples of uncoated steel, galvanized steel, and uncoated aluminum were subjected to 10 fumigation cycles. No damage was detected in the calculator and the thermostat. Both the uncoated steel and the galvanized steel showed signs of oxidation. The aluminum did not show signs of oxidation.
Immobilization of .BETA.-galactosidase by polyacrylamide in the presence of protective agents. (1975)

β-Galactosidase from Aspergillus oryzae was immobilized in crosslinked polyacrylamide gel beads. The presence of the enzyme inhibitor, such as glucono-δ-lactone or galactonoy-lactone, during polymerization procedure enhanced the residual enzymatic activity in the polymer beads, and activity yield attained up to 45%. Such enhancement effect was also observed when bovine serum albumin, dithiothreitol or glutathione was added during polymerization. Temperature and pH optima were not affected by the immobilization. The Michaelis constants for free and immobilized β-galactosidase were comparable. Lyophilized beads exhibited good stability without loss of enzymatic activity when stored at 4°C for 47 days.
Occupational and Physical Therapy in Hospice (2004)

Occupational and physical therapy have several vital roles in hospice care: maximizing functional ability and comfort to enhance quality of life; assuring patient and caregiver safety; helping people redesign their lives and life goals; engaging people in meaningful and productive occupational endeavors; and providing support around physical, emotional, and spiritual issues at the end of life. This article will examine physical and occupational therapy referral, evaluation, goal setting, practice patterns and interventions, interdisciplinary teaming, and development of a meaningful and important practice arena for practitioners.
Investigating the genetic model for brown stem rot resistance in soybean (2000)

Genetic analyses have indicated that brown stem rot (BSR) resistance in soybean is conferred by dominant alleles at three independent loci, the actions of which may be modified by linked or independent loci. A study was conducted to characterize the inheritance of BSR resistance in PI 567609, a soybean plant introduction from China. Segregating progeny from crosses of PI 567609 with BSR-susceptible and -resistant genotypes were evaluated for response to BSR-causal fungus, Phialophora gregata. Genetic analyses indicated that PI 567609 carries a single gene or cluster of linked genes for brown stem rot resistance, and that this gene (or cluster) is allelic to, or tightly linked to previously identified resistance genes, Rbs1, Rbs2, and Rbs3. Because previous allelism tests indicated that Rbs1, Rbs2, and Rbs3 were unlinked, and molecular mapping studies have indicated that Rbs1, Rbs2, and Rbs3 are linked on molecular linkage group J of soybean, a new model is proposed for BSR resistance. In this model, BSR resistance is controlled through the interaction of alleles at four independent loci, at least two of which are necessary to condition a resistance response. Functional redundancy at three of these loci allows any one of the three to interact with a fourth locus to confer resistance to BSR.
Toward organ printing: Design characteristics, virtual modelling and physical prototyping vascular segments of kidney arterial tree (2011)

Organ printing is defined as the layer by layer additive biofabrication of three-dimensional (3D) tissue and organ constructs using tissue spheroids as building blocks. Ultimately, successful bioprinting of human organ constructs is dependent on a ‘built in’ vascular tree to perfuse and maintain the viability of the organ constructs. Thus, the design of the vascular tree is a critically important step in practical implementation of organ printing technology. Bioprinting a vascular tree requires detailed knowledge of the morphometrical, morphological and biomechanical characteristics of the sequentially branched segments of the natural vascular tree as well as insight on post-printing tissue compaction and remodelling. Toward accomplishing this goal, we characterised the morphometrical, morphological and biomechanical characteristics of the initial segments of the natural kidney arterial vascular tree of the porcine kidney. Computer simulation was used to model compaction of tissue engineered tubular vascular segments with different wall thicknesses virtually biofabricated from closely packed and fused uniformly sized vascular tissue spheroids. The number of concentric layers of tissue spheroids required to bioprint tubular vascular segments with desirable wall thickness and diameter was theoretically estimated. Our results demonstrate that vascular segment compaction correlates well with reported experimental data. Finally, physical prototyping of linear and branched tubular constructs using silicon droplets as physical analogues of tissue spheroids was performed. Thus, virtual and physical prototyping provide important insights into the design parameters and demonstrate the principal feasibility of bioprinting a branched vascular tree using vascular tissue spheroids.