gebhart/patrepeval huggingface dataset:
The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women (2008)

Melanocortin-4 receptor (MC4R) plays critical roles in regulating food intake and energy balance. Recent genome wide scans found common variants near MC4R were related to obesity and insulin resistance. We examined the associations of the reported variants rs17782313 (T>C) and rs17700633 (G>A) with dietary intakes, weight change and diabetes risk in 5724 women (1533 with type 2 diabetes) from a prospective cohort. Under an additive inheritance model, SNP rs17782313 was significantly associated with high intakes of total energy (P = 0.028), total fat (P = 0.008) and protein (P = 0.003). Adjustment for age, BMI, diabetes status and other covariates did not appreciably change the associations. The SNP was also associated with significantly increasing trend of percentage of energy from total fat (P for trend = 0.037). The associations between SNP rs17782313 and higher BMI (P = 0.002) were independent of dietary intakes. In addition, carriers of allele-C had 0.2 kg/m(2) greater 10-year increase in BMI from cohort baseline 1976 to 1986 (P = 0.028) compared with the non-carriers. Moreover, per allele-C of rs17782313 was associated with 14% (2-32%) increased risk of type 2 diabetes, adjusting for BMI and other covariates. SNP rs1770833 was not significantly associated with either dietary intakes or obesity traits. In conclusion, the common SNP rs17782313 near MC4R gene was significantly associated with higher intakes of total energy and dietary fat. In addition, the SNP was related to greater long-term weight change and increased risk of diabetes in women.
Penicillin acylase-catalyzed acyl group transfer to amino acids, their esters and peptides: a kinetic study. (1991)

Kinetics of penicillin acylase-catalyzed acyl group transfer to amino acids, their esters and peptides have been analyzed. The synthesized product accumulation curves have clearly expressed a maximum. Amino acids with non-branched side chain alkyl radicals were demonstrated to be effective nucleophiles, with glycine, L-phenylalanine and L-phenylglycine being the best. D-amino acids were shown to possess much lower reactivity. Practically for all L-amino acids and peptides tested, the yield of their N-phenylacetyl derivatives in the course of penicillin acylase-catalyzed acyl group transfer reactions was found to be more than 50%. Optimization of such enzymatic synthesis required to increase its potential on the preparative scale.
Thin-Film Microwave Integrated Circuits (1976)

There has been an increase in the use of thin-film technology for the preparation of microwave circuits since it permits the realization of very complex circuitry with precision, reliability, and economy. The requirements for the realization of such circuits have made it necessary to extend the state of the art of the hybrid technology in many areas. Two new substrate types (fine-grain alumina and fused silica) and low-loss conductor systems that are both solderable and thermocompression (TC) bondable were introduced. Further complications which were overcome included bilevel patterns with laser-drilled plated via-holes, the control and measurement of the alumina substrates dielectric constant, and the use of laser trimming to adjust small geometries of tantalum nitride (Ta <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> N) termination resistors. Precise pattern delineation of conductors by laser machining, sputter etching, and selective plating was evaluated and the latter process was found to be the most economical and reliable, since the selective plating technique depends on good photoresist delineation, resist properties were evaluated with special attention given to the variation of linewidth as a function of exposure conditions and resist adhesion during the plating of the gold conductors to prevent underplating. The line shape of the resist was also determined as a function of exposure, development, mask-to-substrate distance, and postbake conditions. Linewidth tolerances such as ± 2.5 µm on fused silica and ±5.0 µm on alumina were routinely achieved. Microwave integrated circuits (an 18-GHz downconverter, a 1.7-GHz amplifier, a filter, and a demodulator) prepared by this technique are illustrated and their performances are discussed. These circuits are used in a digital transmission system currently under development.
CARDIAC TRANSPLANTATION IN MICE (1973)

Cell-free extracts of donor specific heart, spleen, or liver, injected on day 0 or +4 with respect to the day of cardiac allografting in horse antimouse thymocyte globulin (HAMTG)-treated recipients, resulted in longer graft survival (mean survival time (MST), 6.3–9.9 weeks) than in recipients treated with either extract alone (MST, 1.1–2.2 weeks) or HAMTG alone (MST, 4.3 weeks). Heart extract produced longer cardiac allograft survival than did spleen or liver when injected on day 0 or +4, and only heart extract was effective in prolonging cardiac allograft survival when injected on day +8. Early administration was more effective than late. Low (0.1 mg) doses were most effective. Prolongation of AKR allografts was not obtained in preimmunized CBA mice or in noimmunized H-2-incompatible strain C57BL/6. The tolerant state was specific for the donor antigen used, and third-party H-2-compatible and H-2-incompatible allografts were rejected by mice bearing intact donor-specific cardiac allografts.
Method of Acid Value Determination for Oils Containing Alkali-Labile Esters (2004)

Acid value (AV) determination for identical samples of oil extracts from non-pungent pepper (Capsicum annuum L. var. longum cv. CH-19 sweet) by titrimetry using indicator dye and a potentiometer was found to vary considerably from one laboratory to another. Free fatty acid generation by alkali hydrolysis of capsinoids during titration, with consequent false endpoints was found the major reasons for this. The structure of capsinoid, the principle constituent in non-pungent pepper, is similar to that of capsaicinoid, the difference being that capsinoid is the ester of vanillyl alcohol and fatty acid, whereas capsaicinoid, an acid amide consisting of vanillyl amine and fatty acid. The major members of the capsinoid family are capsiate (4-hydroxy-3-methoxybenzyl-8-methyl-6-nonenoate) and dihydrocapsiate (4-hydroxy-3-methoxybenzyl-8-methylnonanoate). In consideration of the hydrolysis of alkali-labile esters such as capsinoids in oils during AV determination, the authors established an alternative method by which AV can be found with no involvement of artifacts. AV is an index of oil deterioration directly reflecting free fatty acid content. AV was thus determined by quantifying free carboxyl residues subsequent to specific and quantitative modification with the fluorescent labeling reagent 9-anthryldiazomethane (ADAM). Fluorescence-labeled carboxyls were quantified by HPLC, with carboxyls determined by calibrating fluorescence intensity of chromatographic peaks with stearic acid as the control. Relative fluorescent intensity of labeled fatty acids differing in carbon-chain length from 8 to 20 was essentially the same with respect to molar concentration. The present method thus serves as an accurate means for AV determination of oils containing alkali-labile esters.
Aggressive natural killer cell leukemia in an adult with establishment of an NK cell line (1986)

There have been many reports of cases in which chronic increases in the numbers of natural killer (NK) cells have been reported. Whether this is reactive or neoplastic in nature has been debated. We report the first case of an aggressive NK cell leukemia in an adult with establishment of an NK cell line. A 70-year-old man had two spontaneous episodes of jejunal perforation and one month later developed a severe febrile illness with moderate splenomegaly. Hemoglobin was 13.1 g/L, and WBC count was 1.8 X 10(9)/L with 2% large granular lymphocytes (LGLs). Platelet count was 143 X 10(9)/L; prothrombin time (PT) and partial thromboplastin time (PTT) were normal. Bone marrow was infiltrated with 25% to 30% LGLs; serum lysozyme was normal. Serum LDH was initially 1,191 U/L and rose to 6,408 (normal 240 to 525 U/L). Ten days later, the WBC count increased to 99.9 X 10(9)/L with 70% LGL cells; the PT and PTT increased, and the platelet count dropped. No bacterial or viral cause of fever was identified. The cells from peripheral blood were LGLs that stained positively for acid phosphatase. All of the LGLs reacted with a monoclonal antibody reactive with NK cells (LEU-11b). Functionally, the patient's peripheral blood mononuclear cells (PBMs) demonstrated 100 times more lytic activity against K562 tumor cell lines than did normal PBMs. The patient's PBMs were propagated in vitro. The cultured cells showed the morphological, cytochemical, immunological, and functional characteristics of NK cells. In addition, partial trisomy involving chromosome 1 q with duplication in regions of q21 through q31 was observed in all metaphases analyzed. The extra chromosome 1q with duplication in regions q21 through q31 was translocated to the p-terminal of chromosome 5. One percent to 5% of normal PBMs comprise NK cells; in most cases, leukemias arise from normal phenotypic counterparts. This case demonstrated that aggressive NK cell leukemia may occur in adults. In addition, the chromosomal abnormalities suggest that this is not a reactive process but a malignancy.
Transport and Equilibrium Phenomena in Gas-Elastomer Systems. I. Kinetic Phenomena (1949)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation R. M. Barrer, G. Skirrow; Transport and Equilibrium Phenomena in Gas-Elastomer Systems. I. Kinetic Phenomena. Rubber Chemistry and Technology 1 June 1949; 22 (2): 427–440. doi: https://doi.org/10.5254/1.3542971 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search
Aggregation across the length-scales in β-lactoglobulin (2004)

The protein beta-lactoglobulin (BLG) has been widely studied, in large part because of its importance to the food industry. Following denaturation during heating, under different conditions of pH it has been found to form either particulate (around the isoelectric point at pH 5.1) or fibrillar gels. The nature of the fibrils has recently been suggested to be the same as that identified with amyloid fibrils known for a wide-range of different proteins and implicated in many disease states. We confirm that the BLG fibrils show all the classical signatures of amyloid fibrils. In addition, the fibrils are capable themselves of aggregating further to form large-scale (many microns in size) spherulites. Polarized light microscopy and Environmental scanning electron microscopy (ESEM) have been used to explore the internal structure of these spherulites under conditions in which the solvent has not been dried off. The factors which determine whether or not the spherulites form have also been considered, together with implications for other amyloid-containing systems.
An Automatic Analyzer for Organic Compounds in Water Based on Solid-Phase Microextraction Coupled to Gas Chromatography (1999)

An automated system for quasi-continuous and on-site monitoring of organic compounds in water is presented. It is based on solid-phase microextraction (SPME) coupled to gas chromatography (GC) using a stopped-flow approach. The analytes are extracted either by direct or headspace SPME. All steps including sampling, sample preparation, extraction, chromatographic separation, and detection are fully automated. Using industrial wastewater as an example, the system was extensively validated both in the laboratory and in the field. Thus, relative standard deviations ranging from 1 to 7% were found for 24 compounds typically present in the wastewater of a chemical plant in Germany. Unattended operation of the system at a wastewater plant for more than one week is possible. Remote control via modem allows easy access to the system and the analytical data from any place.
Donepezil Is Associated with Delayed Nursing Home Placement in Patients with Alzheimer's Disease (2003)

Use of donepezil by AD patients resulted in significant delays in NHP. Long-term use of donepezil may help AD patients live longer in community settings, with consequent personal, social, and economic benefits.
Public opinion on abortion. (1998)

This brief article reports on an opinion poll conducted by Gallup for the "Sunday Telegraph" in 1997, on the eve of the 30th anniversary of the 1967 Abortion Act. The poll revealed that 59% of women thought the current law should be adjusted to allow abortions only up to 10 weeks' gestation. However, this response may be misleading due to pollsters' comparison of the British and French abortion law and the misinformation about French provisions. In fact, France allows abortions up to 10 weeks on request, and under special circumstances thereafter. 79% supported the provision of abortions through the National Health Service. A poll conducted by the Institute of Economic Affairs found that 56% agreed, 28% disagreed, and 16% neither agreed nor disagreed that "abortion should be legally available on demand for all." Parliamentarians should be informed that 59% of Conservative voters, 59% of Labor voters, and 53% of Liberal Democrat voters agreed with support for legal abortion. 27% of Conservative voters, 26% of Labor voters, and 33% of Liberal Democrat voters disagreed with legal abortion. A poll commissioned for Baraclough Carey, a television production company, found that people were generally well-informed about the gestation age at which abortions were usually performed. 58% answered correctly that abortions were performed under 13 weeks' gestation. 15% believed that abortions were performed between 13 and 19 weeks' gestation; 6% believed they were performed between 20 and 26 weeks. 20% did not know at what gestational age abortions were performed.
The Current Status of the Soybean-Soybean Mosaic Virus (SMV) Pathosystem (2016)

<i>Soybean mosaic virus</i> (SMV) is one of the most devastating pathogens that cost huge economic losses in soybean production worldwide. Due to the duplicated genome, clustered and highly homologous nature of <i>R</i> genes, as well as recalcitrant to transformation, soybean disease resistance studies is largely lagging compared with other diploid crops. In this review, we focus on the major advances that have been made in identifying both the virulence/avirulence factors of SMV and mapping of SMV resistant genes in soybean. In addition, we review the progress in dissecting the SMV resistant signaling pathways in soybean, with a special focus on the studies using virus-induced gene silencing. The soybean genome has been fully sequenced, and the increasingly saturated SNP markers have been identified. With these resources available together with the newly developed genome editing tools, and more efficient soybean transformation system, cloning SMV resistant genes, and ultimately generating cultivars with a broader spectrum resistance to SMV are becoming more realistic than ever.
An analytic characterization of the harmonic detection of resonance method (2009)

While it has proven useful as a sensor and as a system for exploring and examining nonlinear oscillation, the harmonic detection of resonance (HDR) method has not been fully derived and explained analytically. We develop the equation of motion for the oscillation of a cantilever which is electrostatically driven into resonance and compared to experiment. The resonance signal is measured both by a photodetector (mechanical signal) and a charge amplifier (electrical signal) and is found to be in good agreement with the derived equation of motion. Finally, a few nonlinear phenomena observed in our HDR experiments will be examined analytically.
Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains (2003)

Heat shock proteins (hsp) are known to facilitate the generation of specific immune responses by chaperoning proteins and peptides involved in T cell activation. Hsp have been shown to be strikingly elevated in multiple sclerosis (MS) lesions. The unique chaperonin properties of hsp70 have allowed identification of immunogenic proteins bound to it by the ex vivo demonstration of hsp associations with proteins implicated in the immune response. We have investigated the association of hsp70 with myelin basic protein (MBP), myelin proteolipid protein (PLP) and myelin oligodendrocyte protein (MOG) in MS and control brain tissue. In co-immunoprecipitation experiments, in all samples of MS brains examined (n = 3), but not control brain tissue (n = 3), direct association of MBP with hsp70, but not with hsp90, was found. In some MS brain samples, association between PLP and hsp70 was also seen. In similar co-immunoprecipitation experiments on brain tissue obtained from mice with experimental autoimmune encephalomyelitis (n = 5) induced by immunization with PLP peptide, specific association of hsp70 with PLP and MBP was found. Using surface plasmon resonance we demonstrated specific binding of hsp70 with MBP in vitro. Analysis of the amounts of MBP bound to hsp70 yielded a molecular ratio of MBP binding to hsp70 at 6.5:1. MBP complexed with hsp70 was taken up at significantly higher rates by antigen-presenting cells than MBP alone and enhanced MBP-specific immune responses. These results indicate that hsp70 specifically associates with MBP in MS brain tissue. This association might be relevant to the enhanced immune recognition of MBP in MS.
Routing and wavelength assignment in all-optical networks (1995)

Considers routing connections in a reconfigurable optical network using WDM. Each connection between a pair of nodes in the network is assigned a path through the network and a wavelength on that path, such that connections whose paths share a common link in the network are assigned different wavelengths. The authors derive an upper bound on the carried traffic of connections (or equivalently, a lower bound on the blocking probability) for any routing and wavelength assignment (RWA) algorithm in such a network. The bound scales with the number of wavelengths and is achieved asymptotically (when a large number of wavelengths is available) by a fixed RWA algorithm. The bound can be used as a metric against which the performance of different RWA algorithms can be compared for networks of moderate size. The authors illustrate this by comparing the performance of a simple shortest-path RWA (SP-RWA) algorithm via simulation relative to the bound. They also derive a similar bound for optical networks using dynamic wavelength converters, which are equivalent to circuit-switched telephone networks, and compare the two cases. Finally, they quantify the amount of wavelength reuse achievable in large networks using the SP-RWA via simulation as a function of the number of wavelengths, number of edges, and number of nodes for randomly constructed networks as well as de Bruijn networks. They also quantify the difference in wavelength reuse between two different optical node architectures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Kerr Cell Camera and Flash Illumination Unit for Ballistic Photography (1950)

This paper describes an experimental model of a combination Kerr cell camera and flash illumination unit designed specifically for the photography of projectiles under conditions of strong ambient illumination. Specific cases wherein such conditions are found are considered and the applicability of the Kerr cell as a secondary protecting shutter is described. A description is given of a pulse forming network—pulse transformer circuit designed to apply an operating voltage pulse to a Kerr cell of thirty-six (36) kilovolts amplitude and one point nine (1.9) microseconds duration. Limitations inherent in the present equipment are considered together with proposals for overcoming these defects in future models. Typical results are presented, including (a) a picture taken with the unit showing a twenty-millimeter shot at the time of emergence from the muzzle of a gun, and (b) a picture of a thirty-seven millimeter shot taken shortly after penetration of a metal target plate.
Signal-processing algorithm for white-light optical fiber extrinsic Fabry–Perot interferometric sensors (2004)

We present a novel signal-processing algorithm for single-mode optical fiber extrinsic Fabry-Perot interferometric sensors that can achieve both high-resolution, absolute measurement of the cavity length and a large dynamic measurement range simultaneously. The algorithm is based on an accurate model of the characteristics of a fiber-optic sensor that takes into account the phase shift that is due to the coupling of light reflected at the second surface to the lead-in fiber end.
Using nonnegative matrix factorization and concept lattice reduction to visualizing data (2008)

The large volume of data from the large-scale computing platforms for high-fidelity design and simulations, and instrumentation for gathering scientific as well as business data, and huge information in the web, give us some problems if we want to compute all concepts from huge incidence matrix. In some cases, we do not need to compute all concepts, but only some of them. In this paper, we proposed minimizing incidence matrix by using non-negative matrix factorization (NMF), because non-negative matrix factorization (NMF) is an emerging technique with a wide spectrum of potential applications in biomedical data analysis. Modified matrix has lower dimensions and acts as an input for some known algorithms for lattice construction.
X-Myt1, a C2HC type zinc finger protein with a function in neuronal differentiation in Xenopus laevis. (1996)

info:eu-repo/semantics/nonPublished
Comparison of ketorolac and morphine for postoperative pain after major surgery (1992)

This study was designed to determine the relative analgesic efficacy and safety of single intramuscular injections of ketorolac (10 mg or 30 mg) and morphine (10 mg) in patients of either sex with moderate to severe pain after major surgery. In a single-dose, randomised, double-blind study of parallel design, pain was assessed immediately before injection of test medication and at regular intervals for 8 h thereafter. One hundred and seventeen patients (109 undergoing cardiac surgery; 8 lung surgery) were randomized to one of the three treatment groups. Pain intensity was assessed using a 5-point verbal scale before administration of study drugs. Postadministration, at 30 min and hourly for 8 h, pain intensity and pain relief were assessed, again using the 5-point verbal scale. Additionally, as a measure of analgesia, forced expiratory volume (FEV1) was obtained in all patients. Vital signs including blood pressure, pulse, temperature, respiratory rate and blood gases (PaCO2) were recorded prior to and after study medication. Based on hourly pain intensity differences and hourly pain relief observations, ketorolac 10 mg was generally more effective than morphine 10 mg, and ketorolac 30 mg was generally more effective than ketorolac 10 mg. The results of this study show that ketorolac is an effective and safe (with regard to arterial pressure, blood gases and lung function) analgesic for relief of postoperative pain after major surgery in stable patients. No clinically significant adverse effects occurred during the study. One cannot exclude an influence on patients with organ system dysfunction or on parameters not measured in this study.