gebhart/patrepeval huggingface dataset:
Modules, abstract types, and distributed versioning (2001)

In a wide-area distributed system it is often impractical to synchronise software updates, so one must deal with many coexisting versions. We study static typing support for modular wide-area programming, modelling separate compilation/linking and execution of programs that interact along typed channels. Interaction may involve communication of values of abstract types; we provide the developer with fine-grain versioning control of these types to support interoperation of old and new code. The system makes use of a second-class module system with singleton kinds; we give a novel operational semantics for separate compilation/linking and execution and prove soundness.
Nanocomposites based on cellulose whiskers and (semi)conducting conjugated polymers (2007)

Two examples of a new class of functional nanocomposites derived from cellulose nanofibers (referred to as “whiskers”) and (semi)conducting π-conjugated polymers were prepared and studied. The conjugated polymers used were polyaniline (PANI) and a poly(p-phenylene ethynylene) (PPE) derivative with quaternary ammonium side chains. Cellulose whiskers with a typical diameter of around 20 nm, a length of around 1–2 µm, and anionic surface charges were combined with the positively charged π-conjugated polymers to form stable dispersions in polar solvents such as formic acid. Thin films were produced by solution-casting. Their composition was systematically varied to comprise between 65 and 99.4% w/w of the whiskers. Measurements of electrical conductivity, photoluminescence, and mechanical properties reveal that the nanocomposites synergistically combine the electronic characteristics of the conjugated polymers with the outstanding mechanical characteristics of the cellulose scaffold.
A sequential AC/DC power flow algorithm for networks containing Multi-terminal VSC HVDC systems (2010)

In this paper, a sequential AC/DC power flow algorithm is proposed to solve networks containing Multi-terminal Voltage Source Converter High Voltage Direct Current (VSC MTDC) systems. In VSC HVDC technology, the converter losses add up to a significant fraction of the overall system losses. However, they are often neglected or not taken into account in a proper manner in VSC HVDC power flows. The algorithm put forward in this paper takes the converter losses into account using a generalized converter loss model. The converter steady state equations are derived in their most general format, with the AC network power injections as controlled quantities. It is shown that correctly defining the power setpoints with respect to the system bus instead of the converter bus, as is often done to simplify calculations, requires additional iterative calculations. The DC system modelling method proposed in this paper does not impose any restriction on the HVDC grid topology. A VSC MTDC power flow solver is incorporated into MATPOWER to show the validity of the proposed algorithm.
Deacylation and Reacylation for a Series of Acyl Cysteine Proteases, Including Acyl Groups Derived from Novel Chromophoric Substrates (1996)

In order to investigate structure-reactivity relationships within a series of acyl cysteine proteases [Doran, J. D., & Carey, P. R. (1996) Biochemistry 35, 12495-12502], deacylation kinetics have been measured for a number of acyl intermediates involving members of the papain superfamily. Derivatives of the "simple" chromophoric ligand (5-methylthienyl)acrylate (5MTA) and those based on two chromophorically labeled derivatives of peptidyl substrates, viz., 2-[(N-acetyl-L-phenylalanyl)amino]-3-(5-methylthienyl)acrylate (Phe5MTA) and 2-[(N-acetyl-L-alanyl)amino]-3-(5-methylthienyl)acrylate (Ala5MTA), were used to create acyl enzyme adducts with papain, cathepsin B, and cathepsin L. The chromophoric specific substrates were designed to utilize hydrogen-bonding and hydrophobic interactions which are known to be important in promoting catalysis by papain. For cathepsins B and L, removing one of the hydrogen-bonding donors making up the putative oxyanion hole retards deacylation by 3-25-fold, demonstrating that the oxyanion hole has a modest effect on catalysis for these substrates. With the above substrates and the wild-type and oxyanion hole mutants, the values of the deacylation rate constants stretch over a 214-fold range, from 0.07 to 15 x 10(-3) s-1. The pKa for deacylation of [(5-methylthienyl)-acryloyl]papain is 4.9, close to that reported for similar papain intermediates, while that for Ala5MTA-papain is at 3.5, which in the latter likely represents the effect of the P1-S1 and P2-S2 interactions on the environment of histidine-159. For the Phe5MTA-papain the extent of deacylation was found to depend on the pH and the starting acyl enzyme concentration. A simple model has been derived which accounts quantitatively for this behavior, using the assumptions that the protonated form of the acyl product reacylates the enzyme and that in the pH range 5.0-7.5 the ionization of active-site groups has no effect on reacylation. The validity of the first assumption was demonstrated by following the deacylation of Phe5MTA-papain in the presence of the potent inhibitor E-64 [1-(L-trans-epoxysuccinyl-L-leucylamino)-4-guanidinobutane], whereupon complete deacylation occurred at all pHs with a pKa identical to that for Ala5MTA-papain, viz., 3.5.
Drugs in muscular dystrophy of the chicken: Corticosterone ‐21‐acetate (1984)

In a previous series of 22-day evaluations of 31 compounds, only corticosterone-21-acetate (C-21-A) increased righting ability of genetically dystrophic chickens to a greater extent than the standard of comparison, methysergide maleate. In the present study, C-21-A was subjected to longer-term trials of up to 48 days, and additional signs of the myopathy were examined. The highest doses of C-21-A increased righting ability for the duration of the trials, decreased the typically elevated plasma levels of creatine kinase (CK) activity by more than 80%, and improved morphology of the dystrophic pectoralis major muscle at the light microscopic level. The major adverse effect of C-21-A, reduction of body weight, was consistently observed at the relatively high doses needed to increase righting ability. That alone, however, could not account for increased righting ability, and plasma CK activity was decreased even at doses that did not reduce body weight. The results show that C-21-A is the most effective compound yet tested in this system and, perhaps more significantly, provides the first evidence that it is possible to identify compounds that improve muscle morphology in a hereditary myopathy using a short-term, step-wise system.
Low temperature a-Si:H TFT on plastic films: materials and fabrication aspects (2003)

In this work, we developed fabrication technology for a-Si:H thin film transistors (TFTs) at 120/spl deg/C for AM OLED displays on flexible plastic substrates. Our TFTs demonstrate performance very close to those fabricated at 260/spl deg/C. This presentation focuses on materials optimization and fabrication process issues.
Gold-Nanoparticle-Infiltrated Polystyrene Inverse Opals: A Three-Dimensional Platform for Generating Combined Optical Properties (2006)

Photonic crystals incorporating metal nanoparticles have recently attracted increasing interest because they may open a way to generate novel optical properties. Although they provide an opportunity to manipulate combined optical signals, to date, optical properties of these composite materials have been scarcely investigated. Here, we present the first example of gold-nanoparticle-infiltrated polystyrene (GNIPS) inverse opals, which not only preserve localized surface plasmon resonance (LSPR) properties of gold nanoparticles (GNPs), but also replicate photonic features from templates. By varying the refractive index (RI) and the incident angle, the relative shifts between resonance peaks and diffraction peaks are observed. On the basis of the volatilization kinetics of ethanol within the GNIPS films, we investigate the external interactions of LSPR and photonic band gap (PBG). It is found that the LSPR peak of GNPs in GNIPS is unexpectedly red-shifted with the decrease of effective RI. Additionally, due to the reversible change of the two characteristic peaks, these GNIPS films exhibit an optical “on−off switching” capability, which is useful in monitoring the changes of the microenvironment by the permeation and release of surrounding media.
Plasma Membrane Expression of Gonadotropin-Releasing Hormone Receptors: Regulation by Peptide and Nonpeptide Antagonists (2009)

Gonadotropin-releasing hormone acts via cell surface receptors but most human (h) GnRH receptors (GnRHRs) are intracellular. A membrane-permeant nonpeptide antagonist [(2S)-2-[5-[2-(2-axabicyclo[2.2.2]oct-2-yl)-1,1-dimethy-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]-N-(2-pyridin-4-ylethyl)propan-1-amine (IN3)] increases hGnRHR expression at the surface, apparently by facilitating its exit from the endoplasmic reticulum. Here we have quantified GnRHR by automated imaging in HeLa cells transduced with adenovirus expressing hemagglutinin-tagged GnRHR. Consistent with an intracellular site of action, IN3 increases cell surface hGnRHR, and this effect is not blocked or mimicked by membrane-impermeant peptide antagonists [Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-d-Cit-Leu-Arg-Pro-d-Ala-NH(2) (cetrorelix) and antide]. However, when the C-terminal tail of a Xenopus (X) GnRHR was added (h.XGnRHR) to increase expression, both peptides further increased cell surface GnRHR. Cetrorelix also synergized with IN3 to increase expression of hGnRHR and a G-protein coupling-deficient mutant (A261K-hGnRHR). Cetrorelix also increased cell surface expression of hGnRHR, h.XGnRHR, and mouse GnRHR in gonadotrope-lineage LbetaT2 cells, and in HeLa cells it slowed h.XGnRHR internalization (measured by receptor-mediated antihemagglutinin uptake). Thus cetrorelix has effects other than GnRHR blockade; it acts as an inverse agonist in internalization assays, supporting the potential importance of ligand-biased efficacy at GnRHR. We also developed an imaging assay for GnRH function based on Ca(2+)-dependent nuclear translocation of a nuclear factor of activated T cells reporter. Using this in HeLa and LbetaT2 cells, IN3 and cetrorelix behaved as competitive antagonists when coincubated with GnRH, and long-term pretreatment (16 h) with IN3 reduced its effectiveness as an inhibitor whereas pretreatment with cetrorelix increased its inhibitory effect. This distinction between peptide and nonpeptide antagonists may prove important for therapeutic applications of GnRH antagonists.
Decolorization of reactive dyes by the white rot fungus <i>Trametes versicolor</i> in sequencing batch reactors (2001)

The white rot fungus Trametes versicolor was shown to be capable of decolorizing three reactive dyes in a sequencing batch process, using glucose as the carbon and energy source over an extended period without supplementation of new mycelium. Decolorization activity was related to the expression of extracellular peroxidases and could be continuously reactivated by sheering the suspended pellets. Pure culture experiments were carried out simultaneously in agitated Erlenmeyer flasks and in completely stirred tank reactors with two azo dyes, C.I. Reactive Black 5 and C.I. Reactive Red 198 as well as the anthraquinone dye C.I. Reactive Blue 19 (Brilliant Blue R). Results show high and stable degrees of decolorization of 91%-99% in both systems, which could be repeated without decrease in activity over time. Under nonsterile conditions only five cycles of decolorization could be achieved. An increasing bacterial population suppressed fungal growth and the formation of peroxidases.
Description of Ionic Surfactant/Water System by Adjusting Mesoscopic Parameters (2009)

Dissipative particle dynamics simulations were utilized to simulate a model surfactant solution-air system. Amphiphilic surfactant molecules were modeled as dimers composed of a hydrophilic head and a hydrophobic tail. With a simple model, the influence of conservative interaction parameters on the surfactant's properties, including surfactant efficiency and critical micelle concentration (CMC), was investigated in the present research. It is not the surfactant total concentration, but the bulk concentration, that should be employed to achieve the right surfactant properties. It is found that the adjustment of interaction between water and head or air and tail (a(WH) or a(AT)) will result in the obvious change in surfactant efficiency. The parameter that affects CMC the most significantly is the interaction between water and tail (a(WT)). On the basis of the findings about the relationship between conservative interaction parameters and surfactant behaviors, we varied the interaction parameters and simulated a real ionic surfactant system with different tail lengths.
MicroRNA expression in B-cell lymphomas (2012)

Tesis doctoral inédita, leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 04-06-2012
Foxc1 reinforces quiescence in self-renewing hair follicle stem cells (2016)

Stem cell quiescence preserves the cell reservoir by minimizing cell division over extended periods of time. Self-renewal of quiescent stem cells (SCs) requires the reentry into the cell cycle. In this study, we show that murine hair follicle SCs induce the Foxc1 transcription factor when activated. Deleting Foxc1 in activated, but not quiescent, SCs causes failure of the cells to reestablish quiescence and allows premature activation. Deleting Foxc1 in the SC niche of gene-targeted mice leads to loss of the old hair without impairing quiescence. In self-renewing SCs, Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity.
Fluid Kinetics During Hemodialysis (1980)

The reflection coefficient of urea was estimated in the present paper since some clinical experiences suggest an importance of urea dependent osmolality for the circulatory stability. In the physiology, the reflection coefficient of urea is usually regarded to be negligibly small though it varies from one organ to another. The value obtained in the present paper is large and urea was supposed osmotically to be active affecting the fluid movement across the capillary wall. A fall of urea concentration during hemodialysis may aggravate potentially the decrease of circulating blood volume.
Controlled evaluation of BacT/alert standard anaerobic and FAN anaerobic blood culture bottles for the detection of bacteremia and fungemia (1995)

FAN medium was formulated to improve microbial recovery, particularly for fastidious microorganisms and for microorganisms causing sepsis in patients receiving antimicrobial therapy. In a controlled clinical evaluation performed at four university-affiliated hospitals, FAN anaerobic bottles were compared with standard anaerobic bottles for yield, speed of detection of microbial growth, and detection of septic episodes. A total of 10,431 blood culture sets were received; both anaerobic bottles of 7,694 blood culture sets were adequately filled with blood. Altogether, 925 isolates were recovered: 557 that were the cause of sepsis, 99 that were indeterminate as the cause of sepsis, and 269 contaminants. More Staphylococcus aureus (P < 0.001), coagulase-negative staphylococci (P < 0.001), Escherichia coli (P < 0.02), and all microorganisms combined (P < 0.005) were recovered from FAN bottles; more nonfermentative gram-negative bacilli (P < 0.05), Torulopsis glabrata (P < 0.001), and other yeasts (P < 0.01) were recovered from standard bottles. Growth of S. aureus (P < 0.001), coagulase-negative staphylococci (P < 0.001), Enterococcus faecalis (P < 0.025), streptococci other than Streptococcus pneumoniae (P < 0.01), and all microorganisms combined (P < 0.001) was detected earlier in standard bottles; growth of more isolates of E. coli (P < 0.05) and anaerobic bacteria (P < 0.01) was detected earlier in FAN bottles. The mean times to detection were 14.2 and 16.1 h for standard and FAN bottles, respectively. More septic episodes caused by S. aureus (P < 0.001), coagulase-negative staphylococci (P < 0.005), members of the family Enterobacteriaceae (P < 0.02), and all microorganisms combined (P < 0.02) were detected in FAN bottles; more septic episodes caused by nonfermentative gram-negative bacilli (P < 0.025) and yeasts (P < 0.005) were detected in standard bottles. In summary, more isolates (except for strict aerobes) were recovered from FAN bottles than from standard anaerobic bottles. Similarly, significant more septic episodes (except for those caused by strict aerobes) were detected with FAN bottles than with standard anaerobic bottles. With the exception of E. coli and anaerobic bacteria, growth of more isolates was detected earlier in standard anaerobic bottles.
Quantitative measurement of HER2 expression in breast cancers: comparison with ‘real-world’ routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival (2015)

Quantitative HER2 measurement by HERmark is highly sensitive, accurately quantifies HER2 protein expression and correlates well with routine HER2 testing. When HERmark and local HER2 results were discordant, HERmark more accurately predicted overall survival.
Fast Adaptive S-ALOHA Scheme for Event-Driven Machine-to-Machine Communications (2012)

Machine-to-Machine (M2M) communication is now playing a market-changing role in a wide range of business world. However, in event-driven M2M communications, a large number of devices activate within a short period of time, which in turn causes high radio congestions and severe access delay. To address this issue, we propose a Fast Adaptive S- ALOHA (FASA) scheme for M2M communication systems with bursty traffic. The statistics of consecutive idle and collision slots, rather than the observation in a single slot, are used in FASA to accelerate the tracking process of network status. Furthermore, the fast convergence property of FASA is guaranteed by using drift analysis. Simulation results demonstrate that the proposed FASA scheme achieves near-optimal performance in reducing access delay, which outperforms that of traditional additive schemes such as PB-ALOHA. Moreover, compared to multiplicative schemes, FASA shows its robustness even under heavy traffic load in addition to better delay performance.
In Situ Analysis of Single-Stranded and Duplex siRNA Integrity in Living Cells (2006)

To attain the full therapeutic promise of short interfering RNA (siRNA), it is believed that improvements such as increased biostability are critical. Regrettably, thus far, insufficient in situ data are on hand regarding the intracellular stability of siRNAs. We report on the use of an advanced fluorescence-based method to probe the nucleolytic decay of double labeled siRNAs, which are subject to fluorescence resonance energy transfer (FRET). In vitro measurements with RNAse A and cellular extracts demonstrate that the ratio of acceptor (5'-Cy5) to donor (3'-rhodamine green) fluorescence can be used to study the degradation of the labeled siRNA substrates upon donor excitation. Intracellular FRET analysis showed substantial degradation of single-stranded siRNA, whereas duplex siRNA stayed intact during the measured time period. These data underline the high intrinsic nuclease resistance of unmodified duplex siRNA and prove that cellular persistence is much more critical for the single-stranded structure. For the first time, the stability of siRNA is investigated in real-time inside living cells. The fluorescence-based method presented here is a straightforward technique to gain direct information on siRNA integrity inside living cells and provides a bright outlook to learn more about the intracellular fate of siRNA therapeutics.
Low-frequency phase locking in high-inductance superconducting nanowires (2005)

Niobium nitride nanowires show considerable promise as high-speed single-photon detectors. We report the observation of an anomalous low-frequency (∼10MHz) response in long, superconducting NbN nanowires (100nm wide, 4nm thick, and 500μm long). This behavior, although strikingly reminiscent of the ac Josephson effect, can be explained by a relaxation oscillation resulting from the high kinetic inductance of the type II nanowire. We simulate all of the observed effects using a simple resistive-hotspot/series-inductor model. The voltage pulses observed are indistinguishable from the pulses induced by visible photons, and our observations suggest noise-induced relaxation oscillations are one mechanism for the dark counts in photon detectors.
A Method for Disguising Malformed SIP Messages to Evade SIP IDS (2013)

This website is for sale! academypublisher.com is your first and best source for all of the information you’re looking for. From general topics to more of what you would expect to find here, academypublisher.com has it all. We hope you find what you are searching for!
RE–1 Silencing Transcription Factor (REST): Regulation of Neuronal Gene Expression via Modification of the Chromatin Structure (2005)

This chapter contains sections titled: Abstract Tissue-Specific Gene Expression: The Molecular Basis for the Function of a Multicellular Organism Modular Structure of REST Biological Activity of REST Mechanism of Transcriptional Repression by REST: Modulation of the Chromatin Structure Lessons from the REST Knockout Mouse Cell Type-Specific Regulation of REST Target Genes The Role of REST in the Differentiation of Neural Stem Cells Involvement of REST in Brain Dysfunction and Disease Conclusion and Prospects Acknowledgments Abbreviations
A Linear Programming Approach for Optimal Contrast-Tone Mapping (2010)

This paper proposes a novel algorithmic approach of image enhancement via optimal contrast-tone mapping. In a fundamental departure from the current practice of histogram equalization for contrast enhancement, the proposed approach maximizes expected contrast gain subject to an upper limit on tone distortion and optionally to other constraints that suppress artifacts. The underlying contrast-tone optimization problem can be solved efficiently by linear programming. This new constrained optimization approach for image enhancement is general, and the user can add and fine tune the constraints to achieve desired visual effects. Experimental results demonstrate clearly superior performance of the new approach over histogram equalization and its variants.