gebhart/patrepeval huggingface dataset:
Tumor necrosis factor as an autocrine growth factor for neuroblastoma. (1992)

Recombinant tumor necrosis factor (TNF) stimulates the proliferation of two neuroblastoma cell lines, SKNFI and SKNBE, in both serum-free medium and fetal calf serum-supplemented medium but has no effect in medium without insulin. This effect is very similar with TNF doses ranging from 5 to 500 ng/ml but depends on the duration of treatment; when cells are treated for 168 h with TNF, the maximal index of proliferation is observed between 120 and 144 h of treatment. The two neuroblastoma cell lines express type A and type B TNF receptors and contain TNF protein; however, TNF is undetectable in culture supernatants. Treatment of the two neuroblastoma cell lines with a rabbit polyclonal antibody to TNF for 96 h fully inhibits [3H]thymidine incorporation; less than 5% viable cells are left in the samples after treatment. A combination of two monoclonal antibodies against type A and type B TNF receptors also inhibits over 85% of the [3H]thymidine incorporation by the two cell lines after 96 h of treatment; the use of a single antibody has a partial effect, suggesting that both receptors are functional on the neuroblastoma cell lines. Taken together, these results show that TNF is an autocrine growth factor for the two neuroblastoma cell lines SKNFI and SKNBE. The results described above have been confirmed on two other neuroblastoma cell lines, IRM32 and CLB-PE.
Design and positioning of a robot in an environment with obstacles using optimal research (2003)

The authors describe a general method of designing and positioning a robot in an environment in order to solve geometrical problems related to the accessibility of given zones. The approach is characterized by the use of two different types of representation of the solids and of the spaces: a CSG (constructive solid geometry) and an octree representation. Each is well adapted to solve two different problems: collision detection and description of the attained space. In addition, an automatic algorithm is used to design any robot related to any set of Denavit-Hartenberg parameters. The use of an optimal approach makes it possible to define the parameters of the robot and its position and orientation in the environment that satisfy the specified task.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
MEMSCOPT: A source-to-source compiler for dynamic code analysis and loop transformations (2012)

In this paper, we present MEMSCOPT, a source-to-source compiler incorporated in a system level design tool chain for dynamic code analysis and loop transformations targeting memory performance optimization. MEMSCOPT is user interactive, supported by both Windows and Linux platforms and integrates with Visual Studio and NetBeans.
The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors (1993)

To determine whether the steroid antagonist RU486 mediates its antiglucocorticoid and antiprogestin activities by the same or different receptor mechanisms, a direct comparison of RU486 interaction with glucocorticoid (GR) and progesterone (PR) receptors was made. The effects of RU486 on transformation of GR and PR 8-10S complexes in the intact cell and in vitro were analyzed by sucrose density gradient centrifugation, and the in vitro stability of receptor-heat shock protein-90 interactions was analyzed by coimmunoprecipitation. Compared to agonist, RU486 binding produced a reduction in the amount of GR converted from 8S to 4S and stabilized the GR-heat shock protein-90 complex. By contrast, PR-RU486 complexes were transformed both in vitro and in the intact cell to the same extent as receptor-agonist complexes. PR-RU486 complexes sedimented at 5-6S, whereas PR-R5020, GR-RU486, and GR-agonist complexes sedimented at 4S. The portion of GR that undergoes nuclear transformation when bound to RU486 was examined for binding to the glucocorticoid-progesterone response element of the mouse mammary tumor virus by an immunoprecipitation assay. The nuclear-transformed GR-RU486 complex bound the glucocorticoid-progesterone response element with the same affinity as the nuclear-transformed GR-triamcinolone acetonide complex. The electrophoretic mobilities of GR-RU486 complexes and GR-agonist complexes were the same, as determined by gel retardation assay. These results suggest that RU486 exerts its antiglucocorticoid activity at two levels of receptor action: prevention of complete GR transformation and alteration of a step subsequent to GR-DNA binding. As an antiprogestin, RU486 action is exerted predominantly at a post-DNA-binding step.
[Analgesic and anti-inflammatory activity of saponins of Argania spinoza]. (1998)

We studied analgesic and antiinflammatory actions of saponins of Argania spinosa cakes in mice and rats. With oral doses of 50 to 300 mg/kg, we found peripheric analgesic actions equivalent to the acetyl salicylic acid ones. The maximum protection was obtained with 500 mg/kg per os. There is no morphine-like central analgesic effect. Antiinflammatory studies were done in vivo using oedema due to carrageenine or experimental trauma in rats. There was a decrease in the paw swelling at doses of 10 mg/kg per os. At doses of 50 to 100 mg/kg per os, the antiinflammatory effect was similar to the one of indomethacin at doses of 10 to 20 mg/kg per os. In vitro, there was an inhibition of beef synovial fluid degradation by OH. radicals. The inhibition action is evaluated with an IC20 > or = 6 microM. Argania spinosa saponins have also an antiradical action against DPPH (IC25 = 85 mM) and against OH. radicals (IC25 = 0.56 M). Since they do not have any inhibition effect on PGE2 synthesis, their antiinflammatory activity can be explained by their action on leucotriens in the metabolic pathway of arachidonic acid.
Beginnings (2010)

In every field of therapeutic practice a significant amount of time is spent writing letters about and to patients. In Letters From the Clinic Derek Steinberg applies detailed literary and psychological analysis to over 40 letters, highlighting why certain words or phrases were used, how they could have been put better, and builds around them principles and theoretical positions based on narrative therapy, consultative approaches and the psychological impact of words and phrases.Using the context of child, adolescent and family psychiatry, while also applicable to all therapeutic work, the book deals with issues such as* explaining clinical conditions and treatments* confirming clinical contracts* conveying difficult advice and painful news* missed appointments and other practicalitiesEach letter is followed by detailed annotations and discussion.Letters From the Clinic will prove a valuable tool to all those working in clinical and therapeutic practice.
<i>Response</i> : Mutant Mice, Cu,Zn Superoxide Dismutase, and Motor Neuron Degeneration (1994)

Article MetricsDownloadsCitationsNo data available.0246AugSepOctNovDecJan1020Total6 Months12 MonthsTotal number of downloads for the most recent 6 whole calendar months.
Speaker Adaptation for End-to-End CTC Models (2019)

We propose two approaches for speaker adaptation in end-to-end (E2E) automatic speech recognition systems. One is Kullback-Leibler divergence (KLD) regularization and the other is multi-task learning (MTL). Both approaches aim to address the data sparsity especially output target sparsity issue of speaker adaptation in E2E systems. The KLD regularization adapts a model by forcing the output distribution from the adapted model to be close to the unadapted one. The MTL utilizes a jointly trained auxiliary task to improve the performance of the main task. We investigated our approaches on E2E connectionist temporal classification (CTC) models with three different types of output units. Experiments on the Microsoft short message dictation task demonstrated that MTL outperforms KLD regularization. In particular, the MTL adaptation obtained 8.8\% and 4.0\% relative word error rate reductions (WERRs) for supervised and unsupervised adaptations for the word CTC model, and 9.6% and 3.8% relative WERRs for the mix-unit CTC model, respectively.
Strategy and Command: The Italian Campaign and the ‘Anvil’ Controversy, from ‘Trident’ to the Fall of Rome, 1943–44 (1996)

The following chapter will begin by analysing some of the tensions produced in the Anglo-American relationship in the Mediterranean by involvement in operations on the Italian mainland. It will deal with the strategic debates, and misconceptions, that fostered the commitment of ground forces to Italy and also briefly examine some of the problems of operational cooperation that ensued. On many occasions close contact between British and American forces helped to excite national rivalries and promote mutual stereotyping. The British could display a condescending or supercilious manner when dealing with Americans, while the self-confident exuberance and expansiveness of the Americans often irritated the British, who tended to prefer understatement. These kinds of ‘cultural contrasts’ should always be borne in mind as the context in which contentious issues could arise to produce strain in the relationship.1 Changing notions of seniority in the alliance and their bearing on the structure of command in the theatre and operational developments are stressed throughout. The chapter finishes by assessing the controversy over the invasion of southern France that dominated so many of the strategic exchanges in the first part of 1944, as well as its significance for the Mediterranean Command and the Anglo-American alliance in general.
Cognitive outcome in children and young adults who sustained severe and moderate traumatic brain injury 10 years earlier (2009)

Severity of injury is an important factor when assessing outcome, even 10 years after childhood TBI. The TBI group obtained poorer results on most of the measurements compared with healthy controls. Verbal function was strongly affected which needs to be taken into consideration when preparing for rehabilitation programmes. Evaluations of final outcome should not be made before the subjects reach adulthood.
Activated Cdc42-associated Kinase 1 Is a Component of EGF Receptor Signaling Complex and Regulates EGF Receptor Degradation (2006)

Cdc42-associated tyrosine kinase 1 (ACK1) is a specific down-stream effector of Cdc42, a Rho family small G-protein. Previous studies have shown that ACK1 interacts with clathrin heavy chain and is involved in clathrin-coated vesicle endocytosis. Here we report that ACK1 interacted with epidermal growth factor receptor (EGFR) upon EGF stimulation via a region at carboxy terminus that is highly homologous to Gene-33/Mig-6/RALT. The interaction of ACK1 with EGFR was dependent on the kinase activity or tyrosine phosphorylation of EGFR. Immunofluorescent staining using anti-EGFR and GFP-ACK1 indicates that ACK1 was colocalized with EGFR on EEA-1 positive vesicles upon EGF stimulation. Suppression of the expression of ACK1 by ACK-RNAi inhibited ligand-induced degradation of EGFR upon EGF stimulation, suggesting that ACK1 plays an important role in regulation of EGFR degradation in cells. Furthermore, we identified ACK1 as an ubiquitin-binding protein. Through an ubiquitin-association (Uba) domain at the carboxy terminus, ACK1 binds to both poly- and mono-ubiquitin. Overexpression of the Uba domain-deletion mutant of ACK1 blocked the ligand-dependent degradation of EGFR, suggesting that ACK1 regulates EGFR degradation via its Uba domain. Taken together, our studies suggest that ACK1 senses signal of EGF and regulates ligand-induced degradation of EGFR.
Effect of Laughter Yoga on Psychological Well-being and Physiological Measures. (2016)

The initial study demonstrated that LY meets the criteria to qualify for tier 3 under the Title III-D Evidence-based Disease Prevention and Health Promotion Program and that a large number of Americans, regardless of age and physical ability, could benefit from LY.
Deep blue: computer chess and massively parallel systems (1995)

Since the dawn of the computing age, programming a machine to play chess at grandmaster level has been a grand challenge of computer science. As early as 1949 Claude Shannon described how to program a computer to play chess. He introduced many fundamental algorithms that are still used today in almost all chess programs. It was not until 1988 that a computer called Deep Thought, designed by F. H. Hsu, finally defeated a human grandmaster. In 1989 Hsu and Murray Campbell joined IBM Research and carried forward their research into computer chess algorithms and parallel system architectures. A year later a fellow researcher, A.J. Hoane, joined the team and together they started a remarkable journey toward building the world's first massively parallel chess system, Deep Blue. This system, when completed in late 1995, will play chess at the same level as the strongest human chess player. In this paper we will describe IBM's effort in developing this system and its significance in the history of computing.
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer (2015)

Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuronal marker PGP9.5. Isolated nerve fibers (axons) were detected in 28% of invasive ductal carcinomas as compared to only 12% of invasive lobular carcinomas and 8% of ductal carcinomas in situ (p = 0.0003). In invasive breast cancers, the presence of nerve fibers was observed in 15% of lymph node negative tumors and 28% of lymph node positive tumors (p = 0.0031), indicating a relationship with the metastatic potential. In addition, there was an association between the presence of nerve fibers and the expression of nerve growth factor (NGF) in cancer cells (p = 0.0001). In vitro, breast cancer cells were able to induce neurite outgrowth in PC12 cells, and this neurotrophic activity was partially inhibited by anti-NGF blocking antibodies. In conclusion, infiltration by nerve fibers is a feature of the tumor microenvironment that is associated with aggressiveness and involves NGF production by cancer cells. The potential participation of nerve fibers in breast cancer progression needs to be further considered.
Mutational Analysis of UMP Kinase from <i>Escherichia coli</i> (1998)

UMP kinase from Escherichia coli is one of the four regulatory enzymes involved in the de novo biosynthetic pathway of pyrimidine nucleotides. This homohexamer, with no counterpart in eukarya, might serve as a target for new antibacterial drugs. Although the bacterial enzyme does not show sequence similarity with any other known nucleoside monophosphate kinase, two segments between amino acids 35 to 78 and 145 to 194 exhibit 28% identity with phosphoglycerate kinase and 30% identity with aspartokinase, respectively. Based on these similarities, a number of residues of E. coli UMP kinase were selected for site-directed mutagenesis experiments. Biochemical, kinetic, and spectroscopic analysis of the modified proteins identified residues essential for catalysis (Asp146), binding of UMP (Asp174), and interaction with the allosteric effectors, GTP and UTP (Arg62 and Asp77).
A parallel algorithm for finding a separator in planar graphs (1987)

We present a randomized parallel algorithm for finding a simple cycle separator in a planar graph. The size of the separator is O(√n) and it separates the graph so that the largest part contains at most 2/8 · n vertices. Our algorithm takes T = O(log2(n)) time and P = O(n + f1+ε) processors, where n is the number of vertices, f is the number of faces and ε is any positive constant. The algorithm is based on the solution of Lipton and Tarjan [8] for the sequential case which takes O(n) time. Combining our algorithm with the Pan and Reif [12] algorithm, enables us to find a BFS of planar graph in time O(log3(n)) using n1.5/log(n) processors. Using a variation of our algorithm we can construct a simple cycle separator of size O(d · √f) were d is maximum face size.
Effect of Thioridazine on Erythrocytes (2013)

Thioridazine stimulates eryptosis, an effect in part due to entry of extracellular Ca²⁺ and activation of p38 kinase.
Fuzzy based room temperature control by integrating sensors and cameras with a grid (2013)

With energy consumption on the rise, many researches have focused on the process of monitoring resources to ensure energy efficiency. Monitoring indoor environment is vital to control the use of various high consumption rate devices like air-conditioners lights, etc. Based on the brightness of the room one could decide whether to switch on or off the lights. Integrating two complementing technologies in sensor and grid could provide the required facilities for many applications. Low-cost., multimedia sensors connected to distributed decision-making and acting systems supersede the centrally controlled power management systems. In this work, the indoor environment is sensed using sensors (that sense temperature and humidity) and cameras. In this paper, information is synchronized and processed using a wired grid, along with a fuzzy system. The outcome is used to infer the current state of the system and to perform appropriate actions to make the indoor environment conducive for working. Fusion of information from different sources helps to nullify any erroneous information that is received from the sensors or cameras.
Pressurized Infusion: A New and Improved Liquid Composite Molding Process (2018)

Vacuum-assisted resin transfer molding (VARTM) has several inherent shortcomings such as long mold filling times, low fiber volume fraction, and high void content in fabricated laminates. These problems in VARTM mainly arise from the limited compaction of the laminate and low resin pressure. Pressurized infusion (PI) molding introduced in this paper overcomes these disadvantages by (i) applying high compaction pressure on the laminate by an external pressure chamber placed on the mold and (ii) increasing the resin pressure by pressurizing the inlet resin reservoir. The effectiveness of PI molding was verified by fabricating composite laminates at various levels of chamber and inlet pressures and investigating the effect of these parameters on the fill time, fiber volume fraction, and void content. Furthermore, spatial distribution of voids was characterized by employing a unique method, which uses a flatbed scanner to capture the high-resolution planar scan of the fabricated laminates. The results revealed that PI molding reduced fill time by 45%, increased fiber volume fraction by 16%, reduced void content by 98%, improved short beam shear (SBS) strength by 14%, and yielded uniform spatial distribution of voids compared to those obtained by conventional VARTM.
Flow of oil-in-water emulsions through orifice and venturi meters (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlow of oil-in-water emulsions through orifice and venturi metersRajinder PalCite this: Ind. Eng. Chem. Res. 1993, 32, 6, 1212–1217Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ie00018a029https://doi.org/10.1021/ie00018a029research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
AN EFFICIENT PARALLEL ALGORITHM FOR MATRIX-VECTOR MULTIPLICATION (1995)

The multiplication of a vector by a matrix is the kernel operation in many algorithms used in scientific computation. A fast and efficient parallel algorithm for this calculation is therefore desirable. This paper describes a parallel matrix-vector multiplication algorithm which is particularly well suited to dense matrices or matrices with an irregular sparsity pattern. Such matrices can arise from discretizing partial differential equations on irregular grids or from problems exhibiting nearly random connectivity between data structures. The communication cost of the algorithm is independent of the matrix sparsity pattern and is shown to scale as for an n×n matrix on p processors. The algorithm’s performance is demonstrated by using it within the well known NAS conjugate gradient benchmark. This resulted in the fastest run times achieved to date on both the 1024 node nCUBE 2 and the 128 node Intel iPSC/860. Additional improvements to the algorithm which are possible when integrating it with the conjugate gradient algorithm are also discussed.
Evaluation of a Powder Formulation of Pseudomonas fluorescens Pf1 for Control of Rice Sheath Blight (1999)

Pseudomonas fluorescens strain Pf1, inhibitory to the growth of the rice sheath blight pathogen Rhizoctonia solani in vitro , was developed as a talc-based formulation. W hen the formulation was applied as a seed treatment, the bacteria established well in the rice rhizosphere. Root treatment or soil application of the formulation was less effective in establishing the bacteria into the rhizosphere. Effective control of rice sheath blight was obtained when the powder formulation was applied to seed, roots, soil and foliage, and these methods of application increased crop grain yield in four field trials. The possible commercial exploitation of the powder formulation of the bacteria is discussed. Keywords: Biological ControlPseudomonas FluorescensPowder Formulation Rice Sheath BlightRhizoctonia Solani
An adaptive nonlinear diffusion algorithm for filtering medical images (2000)

The nonlinear anisotropic diffusive process has shown the good property of eliminating noise while preserving the accuracy of edges and has been widely used in image processing. However, filtering depends on the threshold of the diffusion process, i.e., the cut-off contrast of edges. The threshold varies from image to image and even from region to region within an image. The problem compounds with intensity distortion and contrast variation. We have developed an adaptive diffusion scheme by applying the Central Limit Theorem to selecting the threshold. Gaussian distribution and Rayleigh distribution are used to estimate the distributions of visual objects in images. Regression under such distributions separates the distribution of the major object from other visual objects in a single-peak histogram. The separation helps to automatically determine the threshold. A fast algorithm is derived for the regression process. The method has been successfully used in filtering various medical images.