gebhart/patrepeval huggingface dataset:
Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product (2016)

W1282X is the fifth most common cystic fibrosis transmembrane regulator (CFTR) mutation that causes cystic fibrosis. Here, we investigated the utility of a small molecule corrector/potentiator strategy, as used for ΔF508-CFTR, to produce functional rescue of the truncated translation product of the W1282X mutation, CFTR<sub>1281</sub>, without the need for read-through. In transfected cell systems, certain potentiators and correctors, including VX-809 and VX-770, increased CFTR<sub>1281</sub> activity. To identify novel correctors and potentiators with potentially greater efficacy on CFTR<sub>1281</sub>, functional screens were done of ∼30,000 synthetic small molecules and drugs/nutraceuticals in CFTR<sub>1281</sub>-transfected cells. Corrector scaffolds of 1-arylpyrazole-4-arylsulfonyl-piperazine and spiro-piperidine-quinazolinone classes were identified with up to ∼5-fold greater efficacy than VX-809, some of which were selective for CFTR<sub>1281</sub>, whereas others also corrected ΔF508-CFTR. Several novel potentiator scaffolds were identified with efficacy comparable with VX-770; remarkably, a phenylsulfonamide-pyrrolopyridine acted synergistically with VX-770 to increase CFTR<sub>1281</sub> function ∼8-fold over that of VX-770 alone, normalizing CFTR<sub>1281</sub> channel activity to that of wild type CFTR. Corrector and potentiator combinations were tested in primary cultures and conditionally reprogrammed cells generated from nasal brushings from one W1282X homozygous subject. Although robust chloride conductance was seen with correctors and potentiators in homozygous ΔF508 cells, increased chloride conductance was not found in W1282X cells despite the presence of adequate transcript levels. Notwithstanding the negative data in W1282X cells from one human subject, we speculate that corrector and potentiator combinations may have therapeutic efficacy in cystic fibrosis caused by the W1282X mutation, although additional studies are needed on human cells from W1282X subjects.
On the degeneracy of the IMRT optimization problem (2002)

One approach to the computation of photon IMRT treatment plans is the formulation of an optimization problem with an objective function that derives from an objective density. An investigation of the second-order properties of such an objective function in a neighborhood of the minimizer opens an intuitive access to many traits of this approach. A general finding is that only a small subset of the parameter space has nonzero curvature, while the objective function is entirely flat in a neighborhood of the minimizer in most directions. The dimension of the subspace of vanishing curvature serves as a measure for the degeneracy of the solution. This finding is important both for algorithm design and evaluation of the mathematical model of clinical intuition, expressed by the objective function. The structure of the subspace of great curvature is found to be imposed on the problem by conflicts between objectives of target and critical structures. These conflicts and their corresponding modes of resolution form a common trait between all reasonable treatment plans of a given case. The high degree of degeneracy makes the use of a conjugate gradient optimization algorithm particularly favorable since the number of iterations to convergence is equivalent to the number of different eigenvalues of the curvature tensor and is hence independent from the number of optimization parameters. A high level of degeneracy of the fluence profiles implies that it should be possible to stipulate further delivery-related conditions without causing severe deterioration of the dose distribution.
Double‐blind, randomized, controlled clinical trial of clofazimine compared with chloroquine in patients with systemic lupus erythematosus (2005)

These findings suggest that CFZ is equally as effective as CDP in controlling cutaneous lesions in SLE patients. However, we cannot exclude the possibility that the CFZ itself could be the cause of systemic lupus flare.
PIEZOELECTRIC PRECIPITATION SENSOR FROM VAISALA (2005)

The new piezoelectric Vaisala RAINCAP  precipitation sensor and measurement method are presented. Unlike commonly used precipitation instruments the Vaisala RAINCAP  precipitation sensor is virtually maintenance free; without any moving parts or components needing emptying and cleaning. Empirical results from Finnish Meteorological Institute test field in Finland and Vaisala test fields in Malaysia and Finland are presented and compared to the traditional tipping-bucket and weighing gauges. It is shown that the Vaisala RAINCAP  precipitation sensor performs especially well in moderate to heavy precipitation, and due to the measurement method is free from the typical sources of error in precipitation measurements.
Bactericidal/permeability-increasing protein (BPI) inhibits angiogenesis via induction of apoptosis in vascular endothelial cells (2000)

Bactericidal/permeability-increasing protein (BPI) has been known for some time to function in killing bacteria and in neutralizing the effects of bacterial endotoxin lipopolysaccharide. In the present study, BPI is found to be a novel endogenous inhibitor of angiogenesis. Within the sub-muM range, BPI shows a concentration-dependent inhibition of endothelial cell (EC) proliferation that is mediated by cell detachment and subsequent induction of apoptosis. As measured by flow cytometric analysis of the percentage of subdiploid cells, apoptosis induction was half-maximal at about 250 nmol/L BPI. Apoptosis was confirmed by quantification of cells with nuclear fragmentation. Apoptosis was found to be EC specific. In an in vitro collagen gel-based angiogenesis assay, BPI at 1.8 micromol/L inhibited tube formation by 81% after only 24 hours. Evidence for in vivo inhibition of angiogenesis was obtained, using the chorioallantoic membrane assay in which BPI was seen to be significantly effective at concentrations as low as 180 nmol/L. This newly discovered function of BPI might provide a possible therapeutic modality for the treatment of various pathologic disorders that depend on angiogenesis.
Persistent wandering atrial pacemaker after epinephrine overdosing – a case report (2013)

Health care providers and parents should be warned of toxicities associated with sympathomimetic drug overdosing. Future studies are needed to determine whether wandering atrial pacemaker is a potential long-term complication of high-dose sympathomimetics.
<title>Development of a real-time laser scanning system for object recognition, inspection, and robot control</title> (1993)

A real-time laser scanner for object recognition, inspection, and robot control is presented in this paper. Range and intensity images are generated in perfect registration at a rate of 10 Mega-samples per second. Images have a resolution of 483 lines each having 512 pixels. Owing to its compatibility with the video standard RS-170, the range camera can be directly interfaced to an image processor through a video frame grabber with either an analog or digital input. The angular field of view is 30 degree(s) X 30 degree(s). The stand-off distance is 0.5 m and the operational depth of field is 1 m. Furthermore, cooperative targets can be measured up to several meters away from the camera. The range resolution is 12 bits. Under normal operating conditions, a range precision of 0.2 mm and 2 mm are achieved at 0.5 m and 1 m respectively. The testing of the prototype is well under way and soon, images of a variety of representative objects will be available.
Blocking by spironolactone (SC 9420) of the action of aldosterone upon the intestinal transport of potassium, sodium, and water. (1966)

This study continues the work described in the previous paper and brings out another common factor concerning electrolyte transport.
Doubleheader Logging: Eliminating Journal Write Overhead for Mobile DBMS (2020)

Various transactional systems use out-of-place up-dates such as logging or copy-on-write mechanisms to update data in a failure-atomic manner. Such out-of-place update methods double the I/O traffic due to back-up copies in the database layer and quadruple the I/O traffic due to the file system journaling. In mobile systems, transaction sizes of mobile apps are known to be tiny and transactions run at low concurrency. For such mobile transactions, legacy out-of-place update methods such as WAL are sub-optimal. In this work, we propose a crash consistent in-place update logging method - doubleheader logging (DHL) for SQLite. DHL prevents previous consistent records from being lost by performing a copy-on-write inside the database page and co-locating the metadata-only journal information within the page. This is done, in turn, with minimal sacrifice to page utilization. DHL is similar to when journaling is disabled, in the sense that it incurs almost no additional overhead in terms of both I/O and computation. Our experimental results show that DHL outperforms other logging methods such as out-of-place update write-ahead logging (WAL) and in-place update multi-version B-tree (MVBT).
Spectroscopy of Molecular Junction Networks Obtained by Place Exchange in 2D Nanoparticle Arrays (2007)

Well ordered nanoparticle arrays were prepared on Si/SiO2 surfaces from alkanethiol-coated Au nanoparticles via self-assembly and micro-contact printing. We study the insertion of conjugated molecular species within the nanoparticle arrays via spectroscopic and electrical transport measurements. Upon exchange of the alkanethiol chains with the conjugated oligomers, the conductance of the network increases by one to 3 orders of magnitude. In addition, the absorption spectra in the visible light range show a red-shift of the surface plasmon resonance (SPR). The latter shift, which is due to the difference in permittivity between alkanes and conjugated oligomers, can be understood within Mie and Maxwell−Garnett theory. Finally, infrared absorption spectra provide direct spectroscopic evidence that the conjugated oligomers can be not only inserted but also, subsequently, fully removed from the nanoparticle arrays via place-exchange. The reversibility of the exchange process demonstrates the potential of these structures as a platform for molecular electronics.
A monoclonal antibody (TA-1) reactive with human T lymphocytes and monocytes. (1980)

Several monoclonal antibodies were produced against the human T lymphocyte leukemia cell line HSB-2 by fusing spleen cells from hyperimmune mice with NS-1 myeloma cells. One clone, designated TA-1, was initially characterized for reactivity with normal and leukemic human hematopoietic cells. Using indirect immunofluorescence, TA-1 was shown to bind to approximately 75% of peripheral blood lymphocytes. Enrichment for T and B lymphocytes followed by double fluorochrome labeling studies revealed that most if not all E+ T lymphocytes and approximately 10% of B lymphocytes were TA-1+. TA-1 also reacted with approximately 67% of thymocytes, mixed lymphocyte culture-activated T lymphocytes, the entire peripheral blood monocyte population, and approximately 13% of nucleated bone marrow cells. TA-1+ cells in bone marrow included both phagocytic and nonphagocytic cells. TA-1 did not bind to peripheral blood granulocytes, red blood cells, or platelets. Studies of acute lymphoblastic leukemia (ALL) revealed that 6 of 11 T-ALL and 1 of 21 E-, SIg--ALL were TA-1+, whereas cells from 10 patients with chronic lymphocytic leukemia were TA-1-. Interestingly, TA-1 was able to distinguish acute myelomonocytic leukemic cells (TA-1+) from acute myelocytic leukemic cells (TA-1-). In summary, these studies demonstrate the existence of determinant recognized by TA-1 that is primarily expressed on cells of T lymphocyte and monocyte/macrophage lineage.
Urinary N-acetyl-beta-D-glucosaminidase (NAG) as an indicator of renal disease. (1979)

The automated fluorimetric assay of N-acetyl-beta-D-glucosaminidase (NAG) has proved to be of value in the detection of rejection in transplant patients and in monitoring the course of renal disease. The urine can be diluted prior to assay, due to the sensitivity of the fluorimetric method and this reduces the effect of endogenous inhibitors. Time consuming dialysis or gel filtration steps are therefore unnecessary. Results are available to the physician within hours of the collection of the urine sample, since factoring the enzyme activity by the creatinine concentration avoids the necessity of collecting twenty-four hour or timed urine samples. Over one hundred samples can be assayed in a day using the automated procedure. The excretion of NAG in normal individuals varies with age and the activity found in pathological samples should always be compared with age-matched controls. The development of a new series of colorimetric substrates has allowed the production of a simple 'Dipstick' which should be of value in the screening of at-risk populations for renal disease. The diagnostic potential of the estimation of urinary NAG activity is enhanced by the separation of its isoenzymic forms by ion-exchange chromatography on DEAE-cellulose.
Accessible GPS: Reorientation and Target Location among users with Visual Impairments (2007)

This article presents the results of two single-subject experiments that were designed to determine consumers’ ability to use a BrailleNote GPS. The participants decreased their mean orientation time from 6 minutes to 45 seconds and increased their target- location efficiency fourfold with BGPS than without BGPS. Additional results and implications for the field are presented.
Synthesis and degradation of phosphoenolpyruvate carboxylase in rat liver and adipose tissue. Changes during a starvation–re-feeding cycle (1973)

A specific antibody against liver cytosol phosphoenolpyruvate carboxylase (EC 4.1.1.32) was used to isolate the enzyme from liver and adipose tissue. With this technique we have shown that phosphoenolpyruvate carboxylase synthesis in starved rats accounts for 3% of the total synthesis of cytosol protein in each tissue. Re-feeding starved animals decreases this relative rate of phosphoenolpyruvate carboxylase synthesis to 0.2% and 1% respectively in liver and adipose tissue, and the activity of the enzyme in each tissue is decreased to 25% of the starvation value. An additional starvation period is accompanied by an increased rate of enzyme synthesis, but the response to starvation is considerably slower than that caused by re-feeding. The degradation rate of phosphoenolpyruvate carboxylase is also subject to regulation. Thus re-feeding starved animals decreases the half-life of the enzyme in liver from 13h to 5.2h, but the rapid rate of degradation is maintained at least during the first 20h of subsequent starvation. Only slight changes in the degradation rate of phosphoenolpyruvate carboxylase are found in adipose tissue. We conclude that the large alterations in the rate of enzyme synthesis during a starvation-re-feeding cycle are the major cause of fluctuations in activity.
Content based image retrieval system using texture and modified block truncation coding (2013)

According to the recent literature, it is pragmatic that image storage and retrieval through the World Wide Web (WWW) has made impressive progress. Practical searching for image still confronts us with present retrieval systems. A Content Based Image Retrieval (CBIR) system provides an efficient way of retrieving related images from image collections. In this paper we present a new technique to extract the images from the database to achieve better performance and efficiency. The novel method uses an approach, which combines texture information and modified Block Truncation Coding (BTC) method to extract the color features from the image. The whole image is divided into a fixed block of size 4 × 4, 8 × 8, 16 × 16, 32 × 32, 64 × 64, 128 × 128 and 256 × 256 non overlapped blocks. For each block, we calculated the threshold as a mean of the pixel values and the number of pixels which are lower than threshold value and upper than the threshold value are counted and mean of these lower and upper values have been taken and these two are considered as features. Now this process is repeated for the all blocks to extract the features of the image. The second step will compute the four texture features using the Gray-Level Co-occurrence Matrix (GLCM) as a statistical approach to extract energy, contrast, entropy and uniformity. We have used this modified BTC and texture features of the image to retrieve images. Finally, we have conducted experiments on a ground truth image database that has 1000 images of different categories. A different block sizes have been used to demonstrate the experimental results and compared with tabulation. From this we have observed that the performance is better and efficiency is low with smaller block sizes and vice versa with higher block sizes. So we have to choose the middle ranges of block sizes for better performance with better efficiency. As we have observed from the results that the performance of the retrieval system is improved because of combination of texture and color features. The proposed system's performance has been improved by an average precision of 2.41% and recall of 8.22% when compared to existing systems.
Toxins from Blue-Green Algae (1977)

Journal Article Toxins from Blue-Green Algae Get access Richard E. Moore Richard E. Moore Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 27, Issue 12, December 1977, Pages 797–802, https://doi.org/10.2307/1297756 Published: 01 December 1977 Article history Accepted: 02 August 1977 Published: 01 December 1977
Effect of Simmondsin Derivatives on Food Intake:  Dose−Response Curves in Rats (1998)

Simmondsin is a food intake-reducing molecule found in the seeds of the jojoba plant (Simmondsia chinensis). Three naturally occurring analogues of simmondsin, simmondsin 2‘-trans-ferulate, 4-demethylsimmondsin, and 4,5-didemethylsimmondsin, were tested for anorexic properties, and dose response curves were constructed. Demethylsimmondsin and didemethylsimmondsin showed no anorexic properties, while simmondsin 2‘-trans-ferulate showed dose-dependent food intake-reducing activity, but, on an equimolar basis, was less active than simmondsin. The food intake-reducing activity of two synthetic derivatives of simmondsin, hydroxymethoxyphenylacetonitrile and simmondsinamide, was also determined, and both were found to be inactive. Keywords: Simmondsin; simmondsin derivatives; jojoba meal; food intake; rats
Improving effects of the mushroom Yamabushitake (<i>Hericium erinaceus</i>) on mild cognitive impairment: a double‐blind placebo‐controlled clinical trial (2008)

A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS-R). After 2 weeks of preliminary examination, 30 subjects were randomized into two 15-person groups, one of which was given Yamabushitake and the other given a placebo. The subjects of the Yamabushitake group took four 250 mg tablets containing 96% of Yamabushitake dry powder three times a day for 16 weeks. After termination of the intake, the subjects were observed for the next 4 weeks. At weeks 8, 12 and 16 of the trial, the Yamabushitake group showed significantly increased scores on the cognitive function scale compared with the placebo group. The Yamabushitake group's scores increased with the duration of intake, but at week 4 after the termination of the 16 weeks intake, the scores decreased significantly. Laboratory tests showed no adverse effect of Yamabushitake. The results obtained in this study suggest that Yamabushitake is effective in improving mild cognitive impairment.
Numerical solution of the general 3D eddy current problem for magnetic induction tomography (spectroscopy) (2003)

Magnetic induction tomography (MIT) is used for reconstructing the changes of the conductivity in a target object using alternating magnetic fields. Applications include, for example, the non-invasive monitoring of oedema in the human brain. A powerful software package has been developed which makes it possible to generate a finite element (FE) model of complex structures and to calculate the eddy currents in the object under investigation. To validate our software a model of a previously published experimental arrangement was generated. The model consists of a coaxial coil system and a conducting sphere which is moved perpendicular to the coil axis (a) in an empty space and (b) in a saline-filled cylindrical tank. The agreement of the measured and simulated data is very good when taking into consideration the systematic measurement errors in case (b). Thus the applicability of the simulation algorithm for two-compartment systems has been demonstrated even in the case of low conductivities and weak contrast. This can be considered an important step towards the solution of the inverse problem of MIT.
Induction of Fetal Hemoglobin Synthesis in Children With Sickle Cell Anemia on Low-Dose Oral Sodium Phenylbutyrate Therapy (2002)

This study was designed to determine if low doses of oral sodium phenylbutyrate (SPB) induce hemoglobin F (HbF) synthesis in children with hemoglobin SS (HbSS). We treated 8 children with HbSS over a period of 5-30 weeks. The initial dose (1.0 g/d) was increased weekly (by 1.0 g/d) until F-reticulocytes doubled. All patients showed an increase in F-reticulocytes (P = 0.002) that was dose-dependent (P = 0.001). Three of 5 patients who continued oral SPB for more than 10 weeks had substantial increases in HbF. We conclude that lower dose SPB is effective in inducing HbF synthesis in some children with HbSS. Further trials are warranted to determine the optimal treatment regimen.
Characterization and Reduction of Audible Magnetic Noise Due to PWM Supply in Induction Machines (2009)

This paper derives the analytical characterization of the Maxwell radial vibrations due to pulsewidth modulation (PWM) supply in induction machines and, particularly, in traction motors supplied with an asynchronous switching frequency. The number of nodes and the velocity of these particular force waves are experimentally validated by visualizing some operational deflection shapes of the stator. It is shown that according to the switching frequency, these forces can be responsible for high magnetic-noise levels during starting and braking. A simple rule to avoid PWM noise is then proposed and applied to an industrial traction motor. Experimental results show that the choice of the switching frequency can have a 15-dB impact on the sound power level emitted by the motor during starting and that a lower switching frequency can sometimes lead to lower magnetic noise. In agreement with analytical predictions, the new proposed switching frequency that avoids resonances between PWM exciting forces and corresponding stator modes reduces the magnetic noise of 5 dB during starting.
Polysilicon resistor trimming for packaged integrated circuits (2002)

Pulse current trimming to adjust values of polysilicon resistors has been investigated for use in full scale IC production. The technique is remarkably accurate, layout efficient, quick and inexpensive from a test perspective, and requires no additional process complexity. The trim process is shown to be reversible to a small, but usable extent for n-type polysilicon. A new physical model consistent with all observations for resistance trim and recovery is presented. Finally, reliability results from extensive burn-in show the trimmed resistors to be exceptionally robust.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>