gebhart/patrepeval huggingface dataset:
Acoustic interference cancellation for a voice-driven interface in smart TVs (2013)

A novel method is proposed to improve the voice recognition performance by suppressing acoustic interferences that add nonlinear distortion to a target recording signal when received by the recognition device. The proposed method is expected to provide the best performance in smart TV environments, where a remote control collects command speech by the internal microphone and performs automatic voice recognition, and the secondary microphone equipped in a TV set provides the reference signal for the background noise source. Due to the transmission channel, the original interference is corrupted nonlinearly, and the conventional speech enhancement techniques such as beamforming and blind signal separation are not applicable. The proposed method first equalizes the interference in the two microphones by maximizing the instantaneous correlation between the nonlinearly related target recording and reference signal, and suppresses the equalized interference. To obtain an optimal estimation of the equalization filter, a method for detecting instantaneous activity of interference is also proposed. The validity of the proposed method is proved by the improvement in automatic voice recognition performance in a simulated TV room where loud TV sounds or babbling speech interfere in a user's commanding speech.
Effect of Intensity of Oral Anticoagulation on Stroke Severity and Mortality in Atrial Fibrillation (2003)

Among patients with nonvalvular atrial fibrillation, anticoagulation that results in an INR of 2.0 or greater reduces not only the frequency of ischemic stroke but also its severity and the risk of death from stroke. Our findings provide further evidence against the use of lower INR target levels in patients with atrial fibrillation.
Layer-By-Layer Assembly of Core-Shell Magnetite Nanoparticles: Effect of Silica Coating on Interparticle Interactions and Magnetic Properties (1999)

Layered magnetic materials have been prepared using layer-by-layer deposition, a technique that allows engineering of the structure of individual particles while remaining simple to carry out. Organic–inorganic sandwich films of superparamagnetic Fe3O4 thus prepared consisted of densely packed assemblies of Fe3O4 nanocrystallites that showed good adhesion to a variety of substrates and excellent mechanical properties. Coating the nanoparticles with a shell of SiO2 was found to greatly reduce the cooperative magnetization switching between adjacent nanoparticles.
Thermal imaging in the detection of bowel ischemia (2000)

Thermal imaging has the potential to be a useful adjunct in the intraoperative determination of bowel ischemia. Further studies are indicated to study this technique.
The binding of 8-methoxypsoralen by human serum albumin. (1978)

The ability of 8-methoxypsoralen (8-MOP) to bind human serum albumin has been investigated in vitro through equilibrium dialysis and fluorescence quenching. By means of the first technique it was observed that, at concentrations presumably close to those obtainable in vivo following its administration in the photochemotherapy of psoriasis, over 80% of 8-MOP was bound to serum albumin. In human serum albumin fluorescence techniques revealed a preferential site of binding for 8-MOP with a high binding constant (Ka = 0.7 X 10(5) M-1) and precise steric requirements, since small conformational variations of the protein molecule were able to abolish its affinity for furocoumarin.
Blind Signal Detection in Massive MIMO: Exploiting the Channel Sparsity (2017)

In practical massive MIMO systems, a substantial portion of system resources are consumed to acquire channel state information (CSI), leading to a drastically lower system capacity compared with the ideal case, where perfect CSI is available. In this paper, we show that the overhead for CSI acquisition can be largely compensated by the potential gain due to the sparsity of the massive MIMO channel in a certain transformed domain. To this end, we propose a novel blind detection scheme that simultaneously estimates the channel and data by factorizing the received signal matrix. We show that by exploiting the channel sparsity, our proposed scheme can achieve a degree of freedom (DoF) very close to the ideal case, provided that the channel is sufficiently sparse. Specifically, the achievable DoF has a fractional gap of only 1/T from the ideal DoF, where T is the channel coherence time. This is a remarkable advance for understanding the performance limit of the massive MIMO system. We further show that the performance advantage of our proposed scheme in the asymptotic SNR regime carries over to the practical SNR regime. Numerical results demonstrate that our proposed scheme significantly outperforms its counterpart schemes in the practical SNR regime under various system configurations.
Revisiting User Mobility and Social Relationships in LBSNs: A Hypergraph Embedding Approach (2019)

Location Based Social Networks (LBSNs) have been widely used as a primary data source to study the impact of mobility and social relationships on each other. Traditional approaches manually define features to characterize users' mobility homophily and social proximity, and show that mobility and social features can help friendship and location prediction tasks, respectively. However, these hand-crafted features not only require tedious human efforts, but also are difficult to generalize. In this paper, by revisiting user mobility and social relationships based on a large-scale LBSN dataset collected over a long-term period, we propose LBSN2Vec, a hypergraph embedding approach designed specifically for LBSN data for automatic feature learning. Specifically, LBSN data intrinsically forms a hypergraph including both user-user edges (friendships) and user-time-POI-semantic hyperedges (check-ins). Based on this hypergraph, we first propose a random-walk-with-stay scheme to jointly sample user check-ins and social relationships, and then learn node embeddings from the sampled (hyper)edges by preserving n-wise node proximity (n = 2 or 4). Our evaluation results show that LBSN2Vec both consistently and significantly outperforms the state-of-the-art graph embedding methods on both friendship and location prediction tasks, with an average improvement of 32.95% and 25.32%, respectively. Moreover, using LBSN2Vec, we discover the asymmetric impact of mobility and social relationships on predicting each other, which can serve as guidelines for future research on friendship and location prediction in LBSNs.
ChemInform Abstract: Dispersion Studies on the System La2O3/γ‐Al2O3. (1989)

Abstract The dispersion of La 2 O 3 , which appears to be the best of the known additives for inhibiting sintering of high‐surface‐area aluminas, in substrates consisting largely of γ‐Al 2 O 3 with minor components of transition aluminas (σ‐ and Θ‐Al 2 O 3 ) is studied by CO chemisorption, AES, Raman spectroscopy, and XRD.
Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells (2008)

The identification of secreted factors that can selectively stimulate the generation of insulin producing beta-cells from stem and/or progenitor cells represent a significant step in the development of stem cell-based beta-cell replacement therapy. By elucidating the molecular mechanisms that regulate the generation of beta-cells during normal pancreatic development such putative factors may be identified. In the mouse, beta-cells increase markedly in numbers from embryonic day (e) 14.5 and onwards, but the extra-cellular signal(s) that promotes the selective generation of beta-cells at these stages remains to be identified. Here we show that the retinoic acid (RA) synthesizing enzyme Raldh1 is expressed in developing mouse and human pancreas at stages when beta-cells are generated. We also provide evidence that RA induces the generation of Ngn3(+) endocrine progenitor cells and stimulates their further differentiation into beta-cells by activating a program of cell differentiation that recapitulates the normal temporal program of beta-cell differentiation.
LONGITUDINAL IMPEDANCE OF THE SQUID GIANT AXON (1941)

Longitudinal alternating current impedance measurements have been made on the squid giant axon over the frequency range from 30 cycles per second to 200 kc. per second. Large sea water electrodes were used and the inter-electrode length was immersed in oil. The impedance at high frequency was approximately as predicted theoretically on the basis of the poorly conducting dielectric characteristics of the membrane previously determined. For the large majority of the axons, the impedance reached a maximum at a low frequency and the reactance then vanished at a frequency between 150 and 300 cycles per second. Below this frequency, the reactance was inductive, reaching a maximum and then approaching zero as the frequency was decreased. The inductive reactance is a property of the axon and requires that it contain an inductive structure. The variation of the impedance with interpolar distance indicates that the inductance is in the membrane. The impedance characteristics of the membrane as calculated from the measured longitudinal impedance of the axon may be expressed by an equivalent membrane circuit containing inductance, capacity, and resistance. For a square centimeter of membrane the capacity of 1 microf with dielectric loss is shunted by the series combination of a resistance of 400 ohms and an inductance of one-fifth henry.
Poly(organophosphazenes) with poly(alkyl ether) side groups: a study of their water solubility and the swelling characteristics of their hydrogels (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(organophosphazenes) with poly(alkyl ether) side groups: a study of their water solubility and the swelling characteristics of their hydrogelsHarry R. Allcock, Shawn R. Pucher, Michael L. Turner, and Richard J. FitzpatrickCite this: Macromolecules 1992, 25, 21, 5573–5577Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ma00047a002https://doi.org/10.1021/ma00047a002research-articleACS PublicationsRequest reuse permissionsArticle Views379Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrasmooth, Highly Spherical Monocrystalline Gold Particles for Precision Plasmonics (2013)

Ultrasmooth, highly spherical monocrystalline gold particles were prepared by a cyclic process of slow growth followed by slow chemical etching, which selectively removes edges and vertices. The etching process effectively makes the surface tension isotropic, so that spheres are favored under quasi-static conditions. It is scalable up to particle sizes of 200 nm or more. The resulting spherical crystals display uniform scattering spectra and consistent optical coupling at small separations, even showing Fano-like resonances in small clusters. The high monodispersity of the particles we demonstrate should facilitate the self-assembly of nanoparticle clusters with uniform optical resonances, which could in turn be used to fabricate optical metafluids. Narrow size distributions are required to control not only the spectral features but also the morphology and yield of clusters in certain assembly schemes.
Multimedia interface design in process control (1992)

In industrial plants, the computer systems that automate and control the processes are becoming increasingly complex. The operators are therefore now less involved in the direct operation of the plant. Instead their role is becoming that of a supervisor monitoring the actions taken by the control system. In this monitoring role they are more concerned with ensuring efficiency rather than safety. Therefore, designers of process control rooms and interfaces are faced with the difficult task of providing the operator with information at appropriate levels of abstraction, in appropriate volumes at appropriate times. The PROMISE (process operators multimedia intelligent support environment) project aims to employ multimedia technology in a system which supports the designer in creating such interfaces. Most current interfaces in the process control area are essentially textual/numerical interfaces perhaps interspersed with the odd graphical display. There are several reasons for believing that communication through multiple media such as text, graphics, animation, sound and speech may be an improvement over most existing interfaces. In particular multiple media presentations should provide: an increased bandwidth enabling larger volumes of information to be communicated, improved means of drawing the operators attention to high priority information, and a wider choice of presentation methods which suggests that the appropriate level of abstraction should be easier to obtain. >
Pharmacology and Potential Use of Cyproterone Acetate (1977)

1 After a lecture presented at the Technical Exhibition "TECHNOGERMA" of the German Federal Republic, Peking/ China, September 5-18, 1975
Antiviral activity of antibiotic peptaibols, chrysospemins B and D, produced by Apiocrea sp. 14T against TMV infection (2000)

A total of about 300 fungal isolates from forest habitats were screened for inhibitors of tobacco mosaic virus (TMV) infection using its local lesion host, Nicotiana tabacum cv. Xanthi nc. One of the isolates, 14T, showed a strong activity against TMV infection, and was identified as an Apiocrea sp. based on its morphological characteristics. Rice was an optimum culture medium for its fermentation, and two antiviral compounds, KGT 141 and KGT 142, were resolved from the rice culture through column chromatography, TLC, and HPLC. By NMR and FAB-MS, the two compounds were identified as chrysospermins B (KGT 141) and D (KGT 142), both of which are peptaibols with 19-mer amino acids possessing an acetylated N-terminus and a hydroxy-amino acid (tryptophanol) at the C-terminus. Both compounds showed inhibitory activities against TMV infection, but chrysospermin D showed the stronger activity than chrysospermin B. The former exhibited 96.3% of TMV-inhibitory efficacy at the concentration of 100 μg/ml and 54.7% at 10 μg/ml, respectively. Furthermore, the chrysospermins were highly cytotoxic toward cancer cell lines of PC-3 (prostrate) and K562 (leukemia), and inhibited growth of the Gram-positive bacteria tested, especially the plant pathogenic bacterium Corynebacterium lilium. To the best of our knowledge, this is the first report on the inhibition of plant virus infection by antimicrobial peptaibols.
Ion implantation doping for AlGaN/GaN HEMTs (2006)

Abstract Selective doping using ion implantation has been developed for the source/drain contacts of AlGaN/GaN high electron mobility transistors (HEMTs). As the annealing temperature of the electrical activation increased, the gate leakage current increased, although the specific contact resistance decreased. The characteristics of ion implanted HEMTs were improved using the optimized annealing temperature of 1150 °C. A saturation drain current of 0.68 A/mm and a maximum transconductance of 0.17 S/mm were obtained without degrading the off‐state breakdown voltage. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Automation of a Flow Cytometry Clinical and Research Laboratory. (1993)

We developed a system to automate a Flow Cytometry Clinical and Research Laboratory. Five major functions are accomplished: 1) patient demographic data entry, 2) specimen results data transfer, 3) procedure transcription and reporting, 4) data query, and 5) data backup and archiving. These are achieved by inter-linking two computers with dissimilar operating systems with a Fluorescence Activated Cell Analyzer (FACScan), several commercially available software systems, an IEEE-488 GPIB parallel cable interface using IEEE protocol and Hewlett Packard User Group software (HPPCLINK), and a customized in-house developed laboratory automation system for integrated database management. The system consists of data entry and editing, procedure results reporting, data query, and data archiving modules. The system design ensures data integrity, quality, and confidentiality.
Predictive Modeling of Physician-Patient Dynamics That Influence Sleep Medication Prescriptions and Clinical Decision-Making (2017)

Insomnia remains under-diagnosed and poorly treated despite its high economic and social costs. Though previous work has examined how patient characteristics affect sleep medication prescriptions, the role of physician characteristics that influence this clinical decision remains unclear. We sought to understand patient and physician factors that influence sleep medication prescribing patterns by analyzing Electronic Medical Records (EMRs) including the narrative clinical notes as well as codified data. Zolpidem and trazodone were the most widely prescribed initial sleep medication in a cohort of 1,105 patients. Some providers showed a historical preference for one medication, which was highly predictive of their future prescribing behavior. Using a predictive model (AUC = 0.77), physician preference largely determined which medication a patient received (OR = 3.13; p = 3 × 10<sup>-37</sup>). In addition to the dominant effect of empirically determined physician preference, discussion of depression in a patient's note was found to have a statistically significant association with receiving a prescription for trazodone (OR = 1.38, p = 0.04). EMR data can yield insights into physician prescribing behavior based on real-world physician-patient interactions.
Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status (2010)

The usefulness of hexamethylenetetramine as an adjuvant to radiation and cisplatin in the treatment of solid tumors and its dependency on the p53 status of tumor cells were examined. Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS/mp53), or with neo vector as a control (SAS/neo), were inoculated subcutaneously into both the hind legs of Balb/cA nude mice. The tumor-bearing mice received 5-bromo-2'-deoxyuridine (BrdU) continuously to label all proliferating (P) cells in the tumors. Then, they received hexamethylenetetramine (HMTA), intraperitoneally or continuously, combined with or without gamma-ray irradiation or cisplatin treatment. Immediately after treatment following HMTA, the response of quiescent (Q) cells was assessed in terms of the micronucleus frequency using immunofluorescence staining for BrdU. The response of the total (= P + Q) tumor cells was determined from the BrdU non-treated tumors. A higher toxicity of HMTA to Q cells than total cells, especially in SAS/neo, was made less clear by continuous administration. There was no apparent difference in the radio- and cisplatin-sensitivity enhancing effects by HMTA combination between SAS/neo and SAS/mp53 tumors, with a slightly greater effect in SAS/mp53. In both SAS/neo and SAS/mp53 tumors, continuous HMTA administration produced higher radio- and cisplatin-sensitivity enhancing effects than intraperitoneal single administration. Therefore, the use of HMTA as an adjuvant to radiation or cisplatin might be promising in curing solid tumors with large fraction of hypoxic cells and also with frequent loss-of-function in p53.
Reversibility of Action of <i>Clostridium Difficile</i> Toxin a on Cho Cells and Intermediate Filaments in Nuclei (1988)

C. difficile, produces 2 potent cytopathic enterotoxins, A and B; their mechanism of action is poorly understood. We studied effects of enterotoxin A (EA) on cultured Chinese Hamster Ovary (CHO) cells employing light microscopy and TEM. Cells grown to 75% confluency were exposed to EA (2.5 μg/ml) at 37°C. Within 1-3 hrs cytoplasm became more retractile and contracted with thin protrusions from the cell (Fig. B). The cells were washed after 2 or 3 hr and incubation continued for 48 hrs. If EA was removed within 2 hrs cells returned to normal in 24-48 hr; if EA was removed after 3 hrs it did not affect rounding of the cells which remained firmly attached and not permeable to erythrosin B implying that they were viable. TEM employing monoclonal Abs and colloidal gold-protein A conjugate showed that at 4°C EA was randomly distributed on plasma membrane (PM). At 37°C EA was located in pinocytotic invaginations and in coated pits (Figs. E-H) suggesting EA internalization by both the bulk and receptor-mediated endocytosis.
Characterization of Gonadotropin-Releasing Hormone Binding to Pituitary Receptors in the Gilthead Seabream (Sparus Aurata)1 (1992)

Receptors for GnRH in the pituitary of Sparus aurata were characterized using iodinated [D-Ala6-Pro9-NEt]-LHRH (GnRHa). Equilibrium binding of the ligand to the receptor was achieved after 1 h at 4 degrees C. Binding of the radioligand was a function of tissue concentration, with a linear correlation over the range of one-sixteenth to three-fourths pituitary per tube. Displacement experiments with salmon GnRH (sGnRH), GnRHa, as well as unrelated peptides demonstrated the specificity of the receptors. Binding was found to be saturable at ligand concentrations of 4 x 10(-9) M. Scatchard analysis of the saturation data suggested the presence of a single class of high-affinity sites (Ka = 0.567 +/- 0.136 x 10(9) M-1, Bmax = 1091 +/- 207 fmol/mg protein).
Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture. (1984)

Four methotrexate (MTX)-resistant sublines of a human squamous cell carcinoma (SCC15) were established in culture by progressive dose escalation. The biochemical basis of resistance was studied. The line with the lowest resistance (R1) had a normal dihydrofolate reductase (DHFR) content but showed decreased MTX transport and polyglutamation. Lines of intermediate resistance (R2 and R3) showed an increased DHFR content and DHFR gene copy number and a defect in MTX transport. The line with the greatest resistance (R4) showed increased DHFR content and gene copy number but nearly normal MTX transport. These results demonstrate that multiple mechanisms of MTX resistance occur in human epithelial cells in culture. We also find evidence of alterations in DHFR gene expression. The MTX-resistant cells were either not cross-resistant or only partly cross-resistant to two lipophilic MTX ester derivatives. These compounds are of potential therapeutic interest for the treatment of MTX-resistant tumors.