gebhart/patrepeval huggingface dataset:
Perturbations in skeletal muscle sarcomere structure in patients with heart failure and Type 2 diabetes: restorative effects of (−)-epicatechinrich cocoa (2013)

HF (heart failure) and T2D (Type 2 diabetes) associate with detrimental alterations in SkM (skeletal muscle) structure/function. We have demonstrated recently that (-)-ERC (epicatechin-rich cocoa) improves SkM mitochondrial structure [Taub, Ramirez-Sanchez, Ciaraldi, Perkins, Murphy, Naviaux, Hogan, Ceballos, Maisel, Henry et al. (2012) Clin. Trans. Sci. 5, 43-47]. We hypothesized that an improved mitochondrial structure may facilitate the reversal of detrimental alterations in sarcomeric microstructure. In a pilot study, five patients with HF and T2D consumed ERC for 3 months; treadmill testing [VO2max (maximum oxygen consumption)] and SkM biopsies were performed. Western blot analysis, immunohistochemistry and electron microscopy were used. We report severe perturbations in components of the DAPC (dystrophin-associated protein complex) as well as sarcomeric microstructure at baseline. ERC induced recovery/enhancement of DAPC protein levels, sarcomeric microstructure and, in a co-ordinated fashion, alterations in markers of SkM growth/differentiation consistent with myofibre regeneration. VO2max increased (~24%) but did not reach statistical significance. These initial results warrant further rigorous investigation, since the use of ERC (or pure epicatechin) may represent a safe and novel means of improving muscle function.
The AMT DAP 500 (1988)

A description is given of the Active Memory Technology DAP 500 series, the first commercial offering of a range of upward-compatible parallel processors. The DAP 500 is a 32*32 array of bit-organized processors based on two previous generations of DAP systems. The DAP 500 is an attached processor available on a wide range of host computers such as the Sun or VAX.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Issue logic for a 600-MHz out-of-order execution microprocessor (1998)

The logic and circuits are presented for a 20-entry instruction queue which scoreboards 80 registers and issues four instructions per cycle in a 600-MHz microprocessor. The request logic and arbiter circuits that control integer execution are described in addition to a novel compaction scheme that maintains temporal order in the queue. The issue logic data path is implemented in 141000 transistors, occupying 10 mm/sup 2/ in a 0.35-/spl mu/m CMOS process.
Effects of capping layer on the spin accumulation and spin torque in magnetic multilayers (2009)

We study the effects of the physical properties of the capping layer (spin diffusion length (SDL), resistivity and interface resistance) on the spin transfer torque (STT) and spin accumulation in the free ferromagnetic (FM) layer of a magnetic multilayer system. The STT and spin accumulation are calculated based on a non-collinear spin drift–diffusion (SDD) model under the assumption of quasi-interfacial absorption of transverse spin accumulation in the FM layers. It is found that the out-of-plane component of the STT in the free FM layer is significantly enhanced by having a thick, highly resistive capping layer, with a long SDL. The in-plane torque component is, however, insensitive to variations in the capping layer properties. The implications of these trends to applications, such as current-induced magnetization switching and spin torque oscillations, are discussed.
Reactions of <i>N</i>-ethylmaleimide with peptides and amino acids (1964)

Research Article| June 01 1964 Reactions of N-ethylmaleimide with peptides and amino acids DG Smyth; DG Smyth Search for other works by this author on: This Site PubMed Google Scholar OO Blumenfeld; OO Blumenfeld Search for other works by this author on: This Site PubMed Google Scholar W Konigsberg W Konigsberg Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1964) 91 (3): 589–595. https://doi.org/10.1042/bj0910589 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation DG Smyth, OO Blumenfeld, W Konigsberg; Reactions of N-ethylmaleimide with peptides and amino acids. Biochem J 1 June 1964; 91 (3): 589–595. doi: https://doi.org/10.1042/bj0910589 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1964 The Biochemical Society1964 Article PDF first page preview Close Modal You do not currently have access to this content.
Cytological mechanisms of gynogenesis and sperm incorporation in unreduced diploid eggs of the clonal loach, <i>Misgurnus anguillicaudatus</i> (Teleostei: Cobitidae) (2006)

The loach Misgurnus anguillicaudatus comprises diploid clonal, triploid and diploid-triploid mosaic individuals in a wild population on Hokkaido island, Japan. When diploid eggs of clonal loaches are fertilized by haploid sperm of normal bisexual loaches, both diploid clonal and non-diploid aclonal individuals occur in the progeny. Flow cytometry and microsatellite analyses revealed that the occurrence of triploid, diploid-triploid and other progeny was essentially due to the genetic incorporation of sperm to diploid clonal genomes of unreduced eggs. In this study, we examined the influence of water temperature from fertilization to early embryogenesis on frequencies of diploid clonal and other progeny and observed that progeny of three out of four clonal females examined exhibited approximately constant rates of diploid clonal individuals (54.2-68.9%) at hatching stage. Thus, no drastic increase of non-diploid progeny was detected. However, the 28 degrees C group of the fourth clonal female gave significantly lower rate (28.1%) of diploid clonal progeny, suggesting that this temperature might be a critical or a borderline temperature inducing sperm incorporation. We also examined the cytological process by which diploid clonal and other aclonal progeny develop after fertilization. In some fertilized eggs, the sperm nucleus remained condensed throughout fertilization and early embryogenesis and never fused with the female pronucleus. This cytological observation concludes that clonal eggs develop by the mechanism of gynogenesis. However, some other eggs showed the cytological process of syngamy between the female pronucleus and an accidentally formed male nucleus, suggesting the formation of triploid progeny. The syngamy between an accidentally activated sperm nucleus with a male pronucleus-like structure and nucleus of a blastomere of gynogenetically developing clonal diploid embryo might produce a diploid-triploid mosaic individual.
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder (1997)

Higher CSF CRF concentrations in patients with PTSD may reflect alterations in stress-related neurotransmitter systems. The higher CSF CRF concentrations may play a role in disturbances of arousal in patients with PTSD.
Evolution of solidification texture during additive manufacturing (2015)

Striking differences in the solidification textures of a nickel based alloy owing to changes in laser scanning pattern during additive manufacturing are examined based on theory and experimental data. Understanding and controlling texture are important because it affects mechanical and chemical properties. Solidification texture depends on the local heat flow directions and competitive grain growth in one of the six <100> preferred growth directions in face centered cubic alloys. Therefore, the heat flow directions are examined for various laser beam scanning patterns based on numerical modeling of heat transfer and fluid flow in three dimensions. Here we show that numerical modeling can not only provide a deeper understanding of the solidification growth patterns during the additive manufacturing, it also serves as a basis for customizing solidification textures which are important for properties and performance of components.
DYRK1A phosphorylates caspase <b>9</b> at an inhibitory site and is potently inhibited in human cells by harmine (2008)

DYRK1A is a member of the dual-specificity tyrosine-phosphorylation-regulated protein kinase family and is implicated in Down's syndrome. Here, we identify the cysteine aspartyl protease caspase 9, a critical component of the intrinsic apoptotic pathway, as a substrate of DYRK1A. Depletion of DYRK1A from human cells by short interfering RNA inhibits the basal phosphorylation of caspase 9 at an inhibitory site, Thr125. DYRK1A-dependent phosphorylation of Thr125 is also blocked by harmine, confirming the use of this beta-carboline alkaloid as a potent inhibitor of DYRK1A in cells. We show that harmine not only inhibits the protein-serine/threonine kinase activity of mature DYRK1A, but also its autophosphorylation on tyrosine during translation, indicating that harmine prevents formation of the active enzyme. When co-expressed in cells, DYRK1A interacts with caspase 9, strongly induces Thr125 phosphorylation and inhibits caspase 9 auto-processing. Phosphorylation of caspase 9 by DYRK1A involves co-localization to the nucleus. These results indicate that DYRK1A sets a threshold for the activation of caspase 9 through basal inhibitory phosphorylation of this protease. Regulation of apoptosis through inhibitory phosphorylation of caspase 9 may play a role in the function of DYRK1A during development and in pathogenesis.
Exploring spatial audio conferencing functionality in multiuser virtual environments (poster session) (2000)

A chatspace was developed that allows conversation with 3D sound using networked streaming in a shared virtual environment. The system provides an interface to advanced audio features, such as a “whisper function” for conveying a confided audio stream. This study explores the use of spatial audio to enhance a user's experience in multiuser virtual environments.
KEEPING AN EYE ON ASIA (1998)

SUBTITLE: YOUR COMPANY SOURCES PRODUCTS IN ASIA, YOU'RE RESPONSIBLE FOR MAKING SURE THE WHOLE PROCESS RUNS SMOOTHLY -- BUT IF YOU'RE HERE, HOW DO YOU KEEP TRACK OF WHAT'S HAPPENING OVER THERE?
On the Fluid Mechanics of Human Coronary Artery Stenosis (1975)

Human coronary artery stenosis can have dramatic hemodynamic effects on coronary flow rate and perfusion. To quantitatively investigate these relationships, nineteen proximal coronary arteries with varying focal stenoses (2%-98%) were dissected from fresh post mortem adult hearts and perfused with isotonic glycerol saline (n = 2.7 centipoise) at constant pressures of 30, 50, 75, 100, 150 and 200 mm Hg, while varying the distal bed resistance (r <L xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</L> ) over the range 0.1 to 5 mm Hg/ml/min. Flow rate (Q) and arterial segment pressure drop (ΔP) were measured at each perfusion pressure and r <L xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</L> , and a permanent cast of silicone rubber was made under 100 mm Hg pressure following perfusion. Hydraulic resistance (R = ΔP/Q) tended to be constant at low Q (10-30 ml/min), with resistance increasing 2 or 3 times at higher Q (30-100 + ml/min). Curves of Q vs. % stenosis showed that Q was relatively constant with stenoses less than 70-80%. With a small further increase in stenosis, however, Q decreased dramatically. Furthermore, significant reductions occurred at lower % stenoses for greater demands (lower r <L xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</L> ), a contributing factor toward effort angina, as less severe stenoses became increasingly significant under flow demand. Elastic effects in eccentric lesions produced additional flow losses at lowered perfusion pressures. In addition, a critical relation was demonstrated between percent stenosis and the minimum coronary perfusion pressure necessary to maintain a given Q.
Molecular Genetics & Gene Therapy of Cardiovascular Diseases (1996)

Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases--including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nea
Cloning and nucleotide sequence of the aroA gene of Bordetella pertussis (1988)

The aroA locus of Bordetella pertussis, encoding 5-enolpyruvylshikimate 3-phosphate synthase, has been cloned into Escherichia coli by using a cosmid vector. The gene is expressed in E. coli and complemented an E. coli aroA mutant. The nucleotide sequence of the B. pertussis aroA gene was determined and contains an open reading frame encoding 442 amino acids, with a calculated molecular weight for 5-enolpyruvylshikimate 3-phosphate synthase of 46,688. The amino acid sequence derived from the nucleotide sequence shows homology with the published amino acid sequences of aroA gene products of other microorganisms.
Hypnosis as an empirically supported clinical intervention: The state of the evidence and a look to the future (2000)

Drawing on the literature reviews of this special issue of the International Journal of Clinical and Experimental Hypnosis (2000), this article summarizes the evidence for the effectiveness of hypnosis as an empirically supported clinical intervention. As a whole, the clinical research to date generally substantiates the claim that hypnotic procedures can ameliorate some psychological and medical conditions, as judged against the Chambless and Hollon methodological guidelines. In many cases, these clinical procedures can also be quite cost-effective. It is probable that with some key empirical refinement a number of other hypnosis treatment protocols will have sufficient empirical documentation to be considered "well-established." However, it is noted that the Chambless and Hollon guidelines are not particularly well-suited for assessing hypnosis' impact when used adjunctly with other interventions. The article concludes with recommendations regarding the efficacy questions that need to be more fully addressed empirically and offers methodological guidelines for researchers and practitioners.
The Effect of Isomer Ratio on the Properties of Bis(4-aminocyclohexyl)methane Polyamides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Effect of Isomer Ratio on the Properties of Bis(4-aminocyclohexyl)methane PolyamidesFrank R. Prince and Eli M. PearceCite this: Macromolecules 1971, 4, 3, 347–350Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/ma60021a020https://doi.org/10.1021/ma60021a020research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient Bottom-Up Mining of Attribute Based Access Control Policies (2017)

Attribute Based Access Control (ABAC) is fast replacing traditional access control models due to its dynamic nature, flexibility and scalability. ABAC is often used in collaborative environments. However, a major hurdle to deploying ABAC is to precisely configure the ABAC policy. In this paper, we present an <i>ABAC mining</i> approach that can automatically discover the appropriate ABAC policy rules. We first show that the ABAC mining problem is equivalent to identifying a set of <i>functional dependencies</i> in relational databases that cover all of the records in a table. We also propose a more efficient algorithm, called ABAC-SRM which discovers the most general policy rules from a set of candidate rules. We experimentally show that ABAC-SRM is accurate and significantly more efficient than the existing state of the art.
Efficient content-based retrieval of motion capture data (2005)

The reuse of human motion capture data to create new, realistic motions by applying morphing and blending techniques has become an important issue in computer animation. This requires the identification and extraction of logically related motions scattered within some data set. Such content-based retrieval of motion capture data, which is the topic of this paper, constitutes a difficult and time-consuming problem due to significant spatio-temporal variations between logically related motions. In our approach, we introduce various kinds of qualitative features describing geometric relations between specified body points of a pose and show how these features induce a time segmentation of motion capture data streams. By incorporating spatio-temporal invariance into the geometric features and adaptive segments, we are able to adopt efficient indexing methods allowing for flexible and efficient content-based retrieval and browsing in huge motion capture databases. Furthermore, we obtain an efficient preprocessing method substantially accelerating the cost-intensive classical dynamic time warping techniques for the time alignment of logically similar motion data streams. We present experimental results on a test data set of more than one million frames, corresponding to 180 minutes of motion. The linearity of our indexing algorithms guarantees the scalability of our results to much larger data sets.
<i>Candida</i> <i>a</i><i>ntarctica</i> Lipase B-Catalyzed Transesterification:  New Synthetic Routes to Copolyesters (2000)

The catalysis by an immobilized preparation of Candida antartica lipase B (Novozyme-435) of transesterification or transacylation between poly(ε-caprolactone), PCL, and poly(ω-pentadecalactone), PPDL, was studied. These reactions between macromolecules were performed in toluene or without solvent (bulk) at 70−75 °C. In bulk, for PCL (Mn = 9.2 × 103) and PPDL (Mn = 4.3 × 103), PDL*CL/CL*PDL diad sequences were observed by 13C NMR within 30 min. By increasing the reaction time from 30 to 60 min, the average-sequence length of CL (μCL) and PDL (μPDL) repeat units along chains decreased from 18 to 2 and 23 to 2, respectively. Transacylation between PCL (Mn = 44.0 × 103, PDI 1.65) and PPDL (Mn = 40.0 × 103, PDI 1.71) was also studied. To reduce diffusion constraints, the reaction was performed in toluene. Multiblock copolymers (Mn = 18.2 × 103 g/mol, PDI 1.92) were formed after 1 h. By increasing the reaction time to 30 h, random Poly(CL-co-PDL) (Mn = 31.2 × 103 g/mol, PDI 1.87) was formed. Transacylation reactions between polyesters are believed to involve intrachain cleavage by the lipase to form an enzyme-activated-chain segment, followed by reaction of this activated segment with the terminal hydroxyl unit of another chain. This hypothesis is supported by the finding that acetylation of chain end hydroxyl units causes a large decrease in the rate of transacylation between PCL and PPDL chains.
Osteoblast differentiation and disinfection induced by nitrogen plasma-treated surfaces (2011)

Plasma technology is widely employed to tailor the surface chemistry of polymeric biomaterials. In this work, nitrogen-containing functional groups were generated on a polymer surface by N₂ plasma immersion ion implantation (PIII). We evaluated the abilities of the resulting surface to inhibit bacterial growth and to enhance osteoblast differentiation from the perspective of bone tissue engineering. Our results demonstrate that the N₂ PIII-treated polymer surface exhibits antibacterial properties against Escherichia coli. Moreover, the N₂ PIII-treated polymer surface has the ability to enhance differentiation of osteoblasts. N₂ PIII-treated polymer surface may therefore be useful in bone tissue engineering.
Flue gas conditioning with SO/sub 3/ to improve precipitator performance (1977)

Cervical somatosensory-evoked potentials and brainstem-click-evoked potentials were recorded from 10 patients with multiple sclerosis before and after a trial of spinal cord stimulation. An improvement in amplitude of the cervical somatosensory-evoked potential was seen in 7 out of 8 patients, while 3 out of 10 showed a decrease in latency of the brainstem-evoked potential. Stimulus currents were measured during spinal cord stimulation, and those patients requiring high currents to evoke a sensation did not derive clinical benefit from spinal cord stimulation.
Capacités dynamiques : le cas de hyundai-kia (2013)

This article seeks to show the interest of the theory of dynamic capacities to analyze the implementation from 2000 to 2010 of a growth strategy of an automobile manufacturer: Hyundai-Kia. Starting from a strategic intention formulated in 2000, the leaders of this company have deployed resources and skills especially in terms of low-cost automobile production. At the same time, the company has made significant expenditures to improve the quality of its products and meet the expectations of customers in different regions of the world. A rigorous dynamic has been implemented for ten years making today this group the fifth largest manufacturer in the world. The theory of dynamic capabilities helps to understand the structural deployment of an organization's strategy.
Distributed query processing strategies in Mermaid, a frontend to data management systems (1984)

The Mermaid testbed system has been developed as part of an ongoing research program at SDC to explore issues in distributed data management. The Mermaid testbed provides a uniform front end that makes the complexity of manipulating data in distributed heterogeneous databases under various data management systems (DBMSs) transparent to the user. It is being used to test query optimization algorithms as well as user interface methodology.
Language identification in noisy environments using throat microphone signals (2005)

Automatic identification of a language in a noisy environment is a challenging task. Performance of a language identification system depends on the quality of the input speech signal. In the presence of high levels of background noise, speech signals recorded using a close-speaking microphone are degraded. In contrast, a throat microphone picks up high quality speech unaffected by the surrounding noise. This paper explores the possibility of using throat microphone speech signals for text-independent language identification in noisy conditions. Languages are modelled using autoassociative neural networks based on the vocal tract system features and excitation source features derived from the throat speech signal. The results of this study show that the throat microphone speech-based language identification system performs well in noisy environments.