gebhart/patrepeval huggingface dataset:
Soluble carbohydrates in desiccation tolerance of yellow lupin seeds during maturation and germination (1997)

Abstract Maturing yellow lupin seeds were desiccation tolerant. Glucose, sucrose and cyclitols (mainly D-pinitol, D- chiro -inositol and myo -inositol) were predominant at the early stages of seed growth. Accumulation of the raffinose family oligosaccharides (RFOs) and the galactosyl cyclitols including galactinol, digalactosyl myo -inositol, galactopinitol A, galactopinitol B, trigalactopinitol A, ciceritol, fagopyritol B1 and fagopyritol B2 appeared during seed maturation; their increase correlated with seed germinability after desiccation. The loss of desiccation tolerance after seed germination was also studied. For the desiccation tolerance test, intact seedlings were dried rapidly or slowly followed by rehydration. Soluble carbohydrates were assayed before and after drying. Root tissues were more sensitive to desiccation than hypocotyl tissues and completely lost desiccation tolerance within 36 h of imbibition after both fast and slow-drying treatments. Survival of hypocotyls decreased gradually up to 96 h after imbibition. Loss of RFOs and galactosyl cyclitols in axis tissues preceded visible germination. Loss of desiccation tolerance was accompanied by loss of RFOs and galactosyl cyclitols and an increase in reducing sugars in cotyledon, hypocotyl and radicle tissues. Drying did not induce the accumulation of RFOs and galactosyl cyclitols in seedling tissues.
Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells (2020)

In humans, sexual dimorphism can manifest in many ways and it is widely studied in several knowledge fields. It is increasing the evidence that also cells differ according to sex, a correlation still little studied and poorly considered when cells are used in scientific research. Specifically, our interest is on the sex-related dimorphism on the human mesenchymal stem cells (hMSCs) transcriptome. A systematic meta-analysis of hMSC microarrays was performed by using the Transcriptome Mapper (TRAM) software. This bioinformatic tool was used to integrate and normalize datasets from multiple sources and allowed us to highlight chromosomal segments and genes differently expressed in hMSCs derived from adipose tissue (hADSCs) of male and female donors. Chromosomal segments and differentially expressed genes in male and female hADSCs resulted to be related to several processes as inflammation, adipogenic and neurogenic differentiation and cell communication. Obtained results lead us to hypothesize that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes. We believe that it should be considered in biologic research and stem cell therapy.
Isoflavones in Soy-Based Infant Formulas (1997)

Six of the major soy-based infant formulas marketed in the United States were assayed for their isoflavone levels. Samples were taken from the east coast, midwestern, and west coast regions of the United States. Isoflavone levels were variable across brands probably due to different amounts of soy isolate used in product formulation. Total isoflavones ranged from 214 to 285 μg/g of dry formula or ≈25−30 μg/mL of reconstituted formula. Keywords: Phytoestrogens; genistein; glycitein; daidzein
Hepatic fibrosis influences the growth of hepatocellular carcinoma. (2008)

In the cases with poor liver function or hepatic fibrosis, cell proliferation cycle might be always activated even if the tumor is small.
Polymorphic characteristics of Kappa casein in Zalawadi goat (2011)

The present work was carried out to analyse the Kappa casein variants in Zalawadi goat breeds by PCR-RFLP method. A total of 50 unrelated blood samples belonging to Zalawadi goats were used for analysis and DNA were extracted from blood samples. All samples were genotyped by PCR-RFLP method, in which BseNI and Alw44I restriction endonuclease were used. PCR-RFLP analysis confirmed GG, GA and AA genotype with BseNI restriction endonuclease and CC, CT, TT genotype with Alw44I restriction endonuclease. The present investigation showed polymorphism of CSN3 gene in Zalawadi goat.
Músicas populares urbanas en los espacios industriales rehabilitados (2013)

Azken hamarkadetako aldaketa ekonomikoen ondorioz, asko izan dira abandonaturik utzitako ekoizpen-espazioak. Horietako asko birgaitu egin dira kulturalki erabiltze aldera. Gure asmoa fenomeno horrek hiri musikekin izan duen lotuta zehaztea da, ikusirik beste arlo artistiko batzuetan (antzerkigintza,arte plastikoak, etab.) horren zantzu nabariak azaldu direla aurretiaz.
Influence of the Lower Jaw Position on the Running Pattern (2015)

The influence of an occlusal splint on running pattern can be confirmed in this study. Wearing a splint increases the symmetry of the running pattern. A more symmetrical running pattern might help to reduce the risk of injuries or help in performance. The change of the movement pattern between the neutral condition and any of the three splint conditions was significant within subjects but not across subjects. Therefore the dental splint has a measureable influence on the running pattern of subjects, however subjects individuality has to be considered when choosing the optimal splint condition for a specific subject.
Reactions which relate to the environmental mobility of arsenic and antimony. I. Quaternization of trimethylarsine and trimethylstibine (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions which relate to the environmental mobility of arsenic and antimony. I. Quaternization of trimethylarsine and trimethylstibineG. E. Parris and F. E. BrinckmanCite this: J. Org. Chem. 1975, 40, 25, 3801–3803Publication Date (Print):December 1, 1975Publication History Published online1 May 2002Published inissue 1 December 1975https://pubs.acs.org/doi/10.1021/jo00913a050https://doi.org/10.1021/jo00913a050research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recent Patents on Computational Intelligence (2010)

The field of computational intelligence is the successor of artificial intelligence.It combines elements of learning, evolution and fuzzy logic to create programs that can exhibit, to some degree, intelligent behaviour.The last few years have seen a growth in theoretical and practical developments in this field.This paper presents an extensive survey of the latest patents in the domain of computational intelligence.It discusses and summarises some of these latest developments in terms of patents.The patents are categorised by their domain of application: Artificial Neural Networks, Fuzzy Logic and Evolutionary Algorithms and further classified by the application area.
Intranasal Insulin Ameliorates Tau Hyperphosphorylation in a Rat Model of Type 2 Diabetes (2012)

Recent studies have demonstrated that insulin plays important roles in the brain, including regulation of glucose metabolism and modulation of learning and memory. We have found dysregulation of brain insulin signaling in both Alzheimer's disease (AD) and type 2 diabetes (T2D), which correlates to hyperphosphorylation of tau, a key abnormal tau modification leading to neurofibrillary tangles. Here, we investigated tau phosphorylation and the two key components of the insulin signaling pathway, protein kinase B (AKT) and glycogen synthase kinase-3β (GSK-3β), in a rat model of T2D produced by a high protein, high glucose, and high fat diet followed by intraperitoneal injection of streptozocin. We found tau hyperphosphorylation, decreased AKT activation, and GSK-3β over-activation in T2D rat brains. Intranasal insulin treatment for four weeks normalized AKT and GSK-3β, as well as reduced tau hyperphosphorylation in T2D rat brains, whereas four-week treatments with subcutaneous insulin had minimal effects on brain GSK-3β and tau phosphorylation. These results suggest decreased brain insulin signaling and tau hyperphosphorylation in the rat model of T2D and demonstrate the efficacy of intranasal insulin treatment to reverse these brain abnormalities. Our findings provide further mechanism by which T2D increases the risk for AD and also support the potential use of intranasal insulin for the treatment of AD.
Fast haze removal for a single remote sensing image using dark channel prior (2012)

Remote sensing images are widely used in various fields. However, they always suffer from the bad weather conditions which also affect their sufficient usage. In order to solve this problem, we propose a simple but effective method to remove haze from a single remote sensing image. Our work is based on the dark channel prior and a common haze imaging model. To eliminate artifacts, we use a low-pass Gaussian filter to refine the coarse estimated atmospheric veil. The experimental results show that our approach achieves good results with very little processing time.
Human Keratinocytes Acquire Cellular Cytotoxicity under UV-B Irradiation (2006)

Ultraviolet (UV) radiation from the sun is widely considered as a major cause of human skin photoaging and skin cancer. Granzyme B (GrB) and perforin (PFN) are two proteins contained in granules and implicated in one of the mechanisms by which cytotoxic lymphocytes and natural killer cells exert their cytotoxicity against virus-infected, alloreactive, or transformed cells. The distribution of GrB and PFN in the skin has received little attention. However, Berthou and co-workers (Berthou, C., Michel, L., Soulie, A., Jean-Louis, F., Flageul, B., Dubertret, L., Sigaux, F., Zhang, Y., and Sasportes, M. (1997) J. Immunol. 159, 5293-5300) described that, whereas freshly isolated epidermal cells did not express GrB or PFN, keratinocyte growth to confluence was associated with GrB and PFN mRNA and protein synthesis. In this work, we have investigated the possible role of UV-B on GrB and PFN expression in keratinocytes. We found that UV-B induces GrB and PFN expression in these cells through redox-, epidermal growth factor receptor-, and mitogen-activated protein kinase-dependent signaling. Furthermore, under UV irradiation, keratinocytes acquire a significant cytotoxicity, which is GrB and PFN dependent, toward a variety of cellular targets including transformed T-lymphocytes, melanocytes, and keratinocytes. This phenomenon may have important functional consequences in the regulation of skin inflammatory response and in the emergence of cancer skin.
[Role p53 and MAPK signaling integration in the regulation of PC12 cell neural differentiation]. (2014)

p53 is a transcription factor and then induced by cellular stress regulates ageing, cell cycle arrest and apoptosis. Published data also demonstrated that p53 participates in the regulation of neuronal differentiation. However, the data concerning the mechanisms of neuronal differentiation by p53 is very limited. In the present work we have studied a role and mechanisms of p53 activated by Nutlin-3 in the differentiation of PC12 cells. In our experiments Nutlin-3 stimulated the cell differentiation by significantly increasing of the neuritis upgrowth and upregulation of tyrosine hydroxylase (TH) expression, the catecholamine main rate-limited ferment. We have also analyzed MAPK signaling cascade that tightly participate in the neuronal differentiation. Obtained data demonstrated that activation of p53 by Nutlin-3 injections increased the activity of cRaf and ERK1/2, as well as transcription factor CREB, which is one of the targets for ERK pathway and regulates transcription of TH. Thus, we demonstrated that p53 activation lead to increased differentiation of PC12 cells and this effect is mediated by cRaf/ERK/CREB pathway.
Silicon Carbide and Related Materials: ECSCRM2000 (2000)

The Third European Conference on Silicon Carbide and Related Materials (ECSCRM2000), held September 3-7, 2000 in Kloster Banz, Germany, developed into a truly important forum in the field of wide bandgap semiconductors. All continents - some 320 participants from 21 different countries - were represented and 15 exhibitors maintained booths and demonstrated the increasingly industrial interest in and the economic impact of the wide bandgap semiconductors. Scientists from Universities and Industry discussed the exciting progress in the fields of SiC and III-Nitrides. Many young scientists have been among the participants; they are regarded as the guarantee to successfully solve the forthcoming tasks. These proceedings reveal the present experimental and theoretical knowledge on the growth of bulk crystals and epitaxial layers, the mechanical, thermal and electronic properties of the grown material, the development of suitable processes and electronic devices, which will have a profound effect on society's ability to better utilize its strategic resources in the future.
Ultra-fast, low-power integrated circuits in a scaled submicron HBT IC technology (2002)

We have developed fast, dense, and low-power integrated circuits using a new scaled IC process. We have fabricated HBTs of 0.3 /spl mu/m/sup 2/ emitter and circuit metalization pitch of 4 /spl mu/m to reduce power and compact the chip size. Submicron HBTs exhibited f/sub T/ of over 160 GHz. We have demonstrated a number of circuits including a low-power comparator test chip clocked at 40 GHz.
Metabolic fate of cholesteryl methyl ether in Mycobacterium phlei. (1975)

Mycobacterium phlei transformed cholesteryl methyl ether into three metabolites: 3beta-methoxy-dinor-5,17(20)-choladien-22-oic methyl ester (I), 3beta-methoxy-5-androsten-17-one (II), and 3beta-methoxy-dinor-5-cholen-22-ol (III). After isolation with thin-layer chromatography, their structures were elucidated by mass, IR and NMR spectroscopy. Compound II was the major product. Compounds I and III were products of various side reactions. In the presence of 8-hydroxyquinoline that inhibits degradation of the steroid nucleus, 1,4-androstadiene-3,17-dione was formed in addition to the compounds mentioned. This indicates that a moderate splitting of the ether bond takes place.
New surface equipment for underbalanced drilling (1997)

Perhaps the single most exciting development in the area of new drilling technology in this decade is underbalanced drilling (UBD). This category includes both jointed pipe and coiled tubing applications. Each has advantages and disadvantages in UBD operations. Regardless of the method selected for a particular UBD application, equipment similarities exist. The surface control and production equipment must be correctly sized and designed for the overall total UBD engineering solution. This article describes the various types, applications and purposes of special surface equipment needed in underbalanced operations. This is the second in a series of articles on UBD technology and its rapid development is this field.
Use of Infectious Molecular Clones of Simian Immunodeficiency Virus for Pathogenesis Studies (1989)

Three infectious molecular clones of SIVmac and one of HIV-2 exhibit remarkable variation in their biological properties despite similarities in genome organization and sequence relatedness. Cloned viruses differed in their ability to grow in various cultured cells, in their ability to infect macaques, and in the location of the env stop codon. Sequences from the 3' end predict that at least three of the four clones do not have an intact, functional nef gene. All four cloned viruses yield infectious virus in HUT-78 and all four cloned viruses are cytopathic.
Expression of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in rat heart during ontogenic development and aging. (1991)

Little is known concerning the molecular mechanisms responsible for changes in sarcoplasmic reticulum (SR) function during ontogenic development and aging except that the amount of SR Ca(2+)-ATPase mRNA varies in these conditions. The aim of the present work was to determine whether SR maturation requires expression of specific isoforms and synchronous accumulation of mRNAs encoding proteins located in SR. Thus, we have studied expression of SR Ca(2+)-ATPase and calsequestrin genes in the rat at different developmental stages from 14 fetal days to 24 months of age. Analysis of alternative splicing of the major Ca(2+)-ATPase gene expressed in heart by nuclease S1 mapping led us to conclude that the Ca(2+)-ATPase gene expressed in heart was not differentially spliced during ontogenic development and senescence. A single calsequestrin mRNA isoform was also detected in rat heart whatever the developmental stage. The amount of specific mRNA was then measured by dot blot and normalized to 18S ribosomal RNA or to myosin heavy chain mRNA. The amount of Ca(2+)-ATPase mRNA relative to 18S RNA increases substantially at the end of fetal life and in the early postnatal period (9.5 +/- 0.5% in the 14-15 day fetus versus 99 +/- 7% in the 4-day-old rat). A stable high level is observed during adulthood. In aged rats (24 months), Ca(2+)-ATPase mRNA represents only 44.6% the amount observed in young adults (1-2 months).(ABSTRACT TRUNCATED AT 250 WORDS)
EXPERIENCES ON VINASSE DISPOSAL: Part III: COMBUSTION OF VINASSE-# 6 FUEL OIL EMULSIONS (1997)

Vinasse, a residual substance left after sugarcane alcohol distillation, represents a major environmental problem for the ethanol industry. No one has found a convenient and economical disposal solution for this black-reddish (Vinasse presents a light brown color and a low total solids content, from 2-4%, when it is obtained from straight sugarcane juice and a black-reddish color and total solids ranging from 5-10% when it is obtained from sugarcane molasses, which is the case of the vinasse used in this study.), viscous, high B.O.D. and acid material which is produced in quantities up to 15 times larger than those of the alcohol itself. This research investigated and developed the basic technology of on-site disposal of vinasse by combustion. Besides the clean ecological benefit, this method promotes energy savings and extra benefits when rich potassium vinasse ash is commercialized. Basic research was conducted using the facilities in the Combustion Laboratory (Mechanical Engineering Dept. at the Louisiana State University Campus in Baton Rouge). This research on vinasse combustion consisted of determining heating values, composition, and flame characteristics through combustion tests. Initially only vinasse was used in different solid concentrations and later emulsions were prepared using vinasse and # 6 fuel oil
Fiber optic metal ion biosensors based on fluorescence resonance energy transfer (1995)

Recently, we have described a fluorescence-based fiber optic biosensor for zinc which uses a metalloenzyme as the sensor transducer. Zinc is bound tightly and specifically to the active site of the enzyme carbonic anhydrase. If we add a fluorescent inhibitor, dansylamide, it binds to the zinc in the active site with concomitant large changes in its fluorescence quantum yield, emission wavelength, and lifetime. In the absence of zinc apocarbonic anhydrase does not bind the inhibitor and one observes the weak, red-shifted, short-lifetime emission of the free dansylamide. These fluorescence changes can be measured through optical fiber and correlated with the zinc concentration, with sub-ppb sensitivity, 50 dB dynamic range, and high selectivity.
Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia. (1999)

BACKGROUND AND PURPOSE: In subjects with subcortical ischemic vascular dementia (SIVD), tissue vacuolization, myelin pallor, and demyelination have been found on pathologic examination of white matter signal hyperintensities (WMSH). Magnetization transfer ratio (MTR) values provide a potential measure of compromised white matter integrity. The purpose of this study was to determine if there were differences in MTR of WMSH between subjects with SIVD and cognitively normal healthy control subjects. METHODS: Fifteen subjects with SIVD and 16 control subjects of comparable age and sex were studied. MTR images were coregistered to MR images segmented into tissue classes (gray matter, white matter, CSF, WMSH, and lacunar infarcts). MTR of WMSH was compared across groups and examined by WMSH location, size, and total burden. RESULTS: WMSH burden was greater in SIVD patients than in control subjects (2.4% vs 0.67%). MTR of WMSH did not differ between groups, but MTR of periventricular WMSH was lower in SIVD patients than in control subjects (37.6% vs 39.4%). Even after accounting for covariant effects of lesion burden, there was still a trend toward reduced periventricular WMSH MTR in the group with dementia. There was no correlation between WMSH MTR and WMSH lesion size. CONCLUSION: These findings are consistent with observations that pathologic changes in vascular dementia are most severe in the periventricular white matter and suggest that insight into the pathophysiology of SIVD might be gleaned from studies of the periventricular region.
The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum. (1996)

N-acetyl-L-leucyl-L-leucyl-L-norleucinal, (LLnL), which inhibits proteasomes in addition to other proteases, was found to prolong the association of major histocompatibility complex class I molecules with the transporters associated with antigen processing (TAP), and to slow their transport out of the endoplasmic reticulum (ER). LLnL induced a reversible accumulation of ubiquitinated proteins and changed the spectrum of peptides bound by class I molecules. These effects can probably be attributed to proteasome inhibition. Unexpectedly, in the TAP-deficient cell line .174, the rate of intracellular transport of human histocompatibility leukocyte antigen (HLA) A2 was also reduced by LLnL, and the generation of most HLA-A2-associated signal sequence peptides was inhibited. The inhibition of HLA-A2 transport in .174 cells was found to be less sensitive to LLnL than in wild-type cells, and a similar difference was found for a second protease inhibitor, benzyloxycarbonyl-L-leucyl-L-leucyl-L-phenylalanilal. These data suggest that under some conditions such inhibitors can block trimming of peptides by an ER peptidase in addition to inhibiting cytosolic peptide generation.
[Expression of endostatin and its relationship with the clinical pathophysiological characteristics in non-small cell lung cancer]. (2002)

The expression of endostatin in NSCLC cancer tissues might be helpful to evaluate the biological behavior of lung cancer.