gebhart/patrepeval huggingface dataset:
Towards historical R-trees (1998)

Article Towards historical R-trees Share on Authors: Mario A. Nascimento CNPTIA - EMBRAPA, P.O. Box 6041, 13083-970 Campinas SP BRAZIL and Institute of Computing of the State University of Campinas CNPTIA - EMBRAPA, P.O. Box 6041, 13083-970 Campinas SP BRAZIL and Institute of Computing of the State University of CampinasView Profile , Jefferson R. O. Silva IC - UNICAMP, P.O. Box 6176, 13083-970 Campinas SP BRAZIL IC - UNICAMP, P.O. Box 6176, 13083-970 Campinas SP BRAZILView Profile Authors Info & Claims SAC '98: Proceedings of the 1998 ACM symposium on Applied ComputingFebruary 1998 Pages 235–240https://doi.org/10.1145/330560.330692Online:27 February 1998Publication History 168citation1,269DownloadsMetricsTotal Citations168Total Downloads1,269Last 12 Months31Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Growing bones : how important is exercise? (2001)

It has been postulated that the antecedents of adult osteoporosis may be present in childhood. Factors that affect skeletal strength and design include genetics, physical activity, hormones, and dietary factors. Of these, the mechanical loading activity of bone is vitally important. During the last decade, animal studies have clearly defined the key role that mechanical loading plays in the attainment of a healthy skeleton. The idea of a 'critical period' at ages 10-12 when the skeleton most readily adapts to physical work has been postulated. Recently a number of prospective intervention trials in children have provided new insights to support this hypothesis. However, the vast majority of pediatric bone studies have been performed with dual-energy X-ray absorptiometric (DXA) systems. Recent studies point out that bone outcomes from DXA may significantly underestimate the effect of exercise intervention on overall bone strength. The aim of this review is firstly, to familiarize the reader with the normal pattern of bone mineral accrual during childhood. The role of exercise in modulating how bone is accrued during childhood and adolescent growth is then discussed. From that foundation, the literature that evaluates the ideal age when childhood physical activity has the most profound effect on bone mass and bone structural parameters (all of which contribute to overall bone strength) is summarized. Some methodological considerations when evaluating the pediatric skeleton using bone densitometry are also discussed. Finally, some studies that have utilized novel approaches to assess bone mass and structural change in the pediatric skeleton are introduced.
Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors (2009)

A dose-escalation, phase I study evaluated the safety, pharmacokinetics, pharmacogenomics, and efficacy of ES-285, a novel agent isolated from a marine mollusc, in adult cancer patients. Patients received a 24-hour i.v. infusion of ES-285 once every 3 weeks until disease progression or unacceptable toxicity. The starting dose was 4 mg/m(2). Dose escalation in cohorts of at least three patients proceeded according to the worst toxicity observed in the previous cohort. Twenty-eight patients were treated with 72 courses of ES-285 across eight dose levels. No dose-limiting toxicities were seen between 4 and 128 mg/m(2). Two of four patients treated at 256 mg/m(2) had dose-limiting reversible grade 3 transaminitis; one patient at 256 mg/m(2) also had transient grade 3 central neurotoxicity. One of three patients subsequently treated at 200 mg/m(2) died following drug-related central neurotoxicity. Other toxicities included phlebitis, nausea, fatigue, and fever. Pharmacokinetic studies indicated dose proportionality with high volume of distribution (median V(ss) at 256 mg/m(2) was 2,389 liters; range, 1,615-4,051 liters) and long elimination half life (median t(1/2) at 256 mg/m(2) was 28 h; range, 21-32 h). The three patients with dose-limiting toxicity had the highest drug exposure. Pharmacogenomic studies of paired surrogate tissue samples identified changes in gene expression following treatment that correlated with increasing dose. Disease stabilization for 6 to 18 weeks was recorded in nine patients. Using this schedule, 128 mg/m(2) was considered safe and feasible. At this dose, pharmacologically relevant concentrations of the drug were safely achieved with pharmacogenomic studies indicating changes in the expression of genes of potential mechanistic relevance.
As Asia's population ages, worries grow about the future (2002)

For more about the East-West Center, see <a href="http://www.eastwestcenter.org/">http://www.eastwestcenter.org/</a>
A comparative analysis of behavioral models for RF power amplifiers (2006)

A comparative study of nonlinear behavioral models with memory for radio-frequency power amplifier (PAs) is presented. The models are static polynomial, parallel Hammerstein (PH), Volterra, and radial basis-function neural network (RBFNN). Two PAs were investigated: one was designed for the third-generation (3G) mobile telecommunication systems and one was designed for the second-generation (2G). The RBFNN reduced the total model error slightly more than the PH, but the error out of band was significantly lower for the PH. The Volterra was found to give a lower model error than did a PH of the same nonlinear order and memory depth. The PH could give a lower model error than the best Volterra, since the former could be identified with a higher nonlinear order and memory depth. The qualitative conclusions are the same for the 2G and 3G PAs, but the model errors are smaller for the latter. For the 3G PA, a static polynomial gave a low model error as low as the best PH and lower than the RBFNN for the hardest cross validation. The models with memory, PH, and RBFNN, showed better cross-validation performance, in terms of lower model errors, than a static polynomial for the hardest cross validation of the 2G PA
Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membrane. (1985)

With monoclonal antibody D-274, raised against guinea pig milk fat globule membrane, the distribution of mucinlike glycoproteins of Mrs greater than or equal to 400,000 was determined in benign fibrocystic disease and infiltrating duct carcinoma of the human breast. These glycoproteins, called collectively PAS-I, were detected in 19 out of 20 cases of benign fibrocystic disease and in at least 26 out of 47 cases of infiltrating duct carcinoma. PAS-I was concentrated on luminal surfaces of ducts and alveoli in morphologically differentiated regions of the tumors. In areas where the glandular nature of the tissue was less evident in infiltrating duct carcinoma, the PAS-I determinant recognized by antibody D-274 was present on irregular luminal surfaces and in the cytoplasm. There was a negative correlation between the short-term recurrence (less than 2 years) of infiltrating duct carcinoma and the detection of strong positive staining with antibody D-274. The results are discussed with reference to recent studies on PAS-I in human breast tissue using monoclonal antibodies raised against human milk fat globule membrane.
Inner Space for TCP Options (2014)

This document describes an experimental method to extend the limited
space for control options in every segment of a TCP connection. It can
use a dual handshake so that, from the very first SYN segment, extra
option space can immediately start to be used optimistically. At the
same time a dual handshake prevents a legacy server from getting
confused and sending the control options to the application as user-
data. The dual handshake is only one strategy - a single handshake
will usually suffice once deployment has got started. The protocol is
designed to traverse most known middleboxes including connection
splitters, because it sits wholly within the TCP Data. It also
provides reliable ordered delivery for control options. Therefore, it
should allow new TCP options to be introduced i) with minimal
middlebox traversal problems; ii) with incremental deployment from
legacy servers; iii) without an extra round of handshaking delay iv)
without having to provide its own loss recovery and ordering mechanism
and v) without arbitrary limits on available space.
Recognition of viral nucleic acids in innate immunity (2009)

Abstract Viral infections are detected by sensor molecules, which initiate innate antiviral responses, including the activation of type I interferons (IFNs) and proinflammatory cytokines. These cytokines are responsible for not only inhibiting viral replication in infected cells but also regulating the induction of adaptive immunity, leading to the swift eradication of viruses. Recent advances in the identification of pathogen receptors in the innate immune system have revealed that distinct types of sensors play a role in the detection of viral nucleic acids in different ways; Toll‐like receptors (TLRs), which detect viral DNA or RNA in endosomal compartments in immune cells, retinoic acid inducible gene‐I (RIG‐I)‐like receptors (RLRs), which recognise viral RNA in the cytoplasm, and DNA sensors, which detect cytoplasmic viral DNA. Since these sensors have to exclusively recognise viral infections, it is intriguing to understand how they distinguish self nucleic acids from foreign viral ones. Here, we review the current knowledge of the recognition of viral nucleic acids by these sensor molecules and the signal transduction machinery. Copyright © 2009 John Wiley & Sons, Ltd.
Effect of Concentration on the Electrochemistry and Speciation of the Magnesium Aluminum Chloride Complex Electrolyte Solution (2017)

Magnesium batteries offer an opportunity to use naturally abundant Mg and achieve large volumetric capacities reaching over four times that of conventional Li-based intercalation anodes. High volumetric capacity is enabled by the use of a Mg metal anode in which charge is stored via electrodeposition and stripping processes, however, electrolytes that support efficient Mg electrodeposition and stripping are few and are often prepared from highly reactive compounds. One interesting electrolyte solution that supports Mg deposition and stripping without the use of highly reactive reagents is the magnesium aluminum chloride complex (MACC) electrolyte. The MACC exhibits high Coulombic efficiencies and low deposition overpotentials following an electrolytic conditioning protocol that stabilizes species necessary for such behavior. Here, we discuss the effect of the MgCl<sub>2</sub> and AlCl<sub>3</sub> concentrations on the deposition overpotential, current density, and the conditioning process. Higher concentrations of MACC exhibit enhanced Mg electrodeposition current density and much faster conditioning. An increase in the salt concentrations causes a shift in the complex equilibria involving both cations. The conditioning process is strongly dependent on the concentration suggesting that the electrolyte is activated through a change in speciation of electrolyte complexes and is not simply due to the annihilation of electrolyte impurities. Additionally, the presence of the [Mg<sub>2</sub>(μ-Cl)<sub>3</sub>·6THF]<sup>+</sup> in the electrolyte solution is again confirmed through careful analysis of experimental Raman spectra coupled with simulation and direct observation of the complex in sonic spray ionization mass spectrometry. Importantly, we suggest that the ∼210 cm<sup>-1</sup> mode commonly observed in the Raman spectra of many Mg electrolytes is indicative of the C<sub>3v</sub> symmetric [Mg<sub>2</sub>(μ-Cl)<sub>3</sub>·6THF]<sup>+</sup>. The 210 cm<sup>-1</sup> mode is present in many electrolytes containing MgCl<sub>2</sub>, so its assignment is of broad interest to the Mg electrolyte community.
Stimulated mitotic counts in the non-lesional skin of patients with psoriasis and controls (1985)

Mitotic counts have been determined in the symptomless skin of nine psoriatic patients and nine healthy controls 48 h after pressure-tape stripping. A significantly increased response was seen in the symptomless psoriatic epidermis compared with the controls.
High Gain Circularly Polarized Wire Antenna For Dsrc Applications (2015)

In this communication, a low-cost circularly polarized wire antenna exhibiting improved gain performance for Dedicated Short Range Communications (DSRC), vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications is presented. The proposed antenna comprises a Y-shaped quarterwavelength monopole antenna surrounded by two iterations of eight conductive arched walls acting as parasitic elements to enhance the overall antenna gain and to shape the radiation pattern in the H-plane. A hemispherical radome shell is added to protect the antenna structure and its effect on the antenna performance is discussed. The designed antenna demonstrates antenna gain of 8.2 dB with omnidirectional far-field radiation pattern in the H-plane. The gain of the proposed antenna is also compared with the characteristic of the stand-alone Y-shaped monopole to highlight the advantages of the proposed approach.
Face recognition/detection by probabilistic decision-based neural network (1997)

This paper proposes a face recognition system, based on probabilistic decision-based neural networks (PDBNN). With technological advance on microelectronic and vision system, high performance automatic techniques on biometric recognition are now becoming economically feasible. Among all the biometric identification methods, face recognition has attracted much attention in recent years because it has potential to be most nonintrusive and user-friendly. The PDBNN face recognition system consists of three modules: First, a face detector finds the location of a human face in an image. Then an eye localizer determines the positions of both eyes in order to generate meaningful feature vectors. The facial region proposed contains eyebrows, eyes, and nose, but excluding mouth (eye-glasses will be allowed). Lastly, the third module is a face recognizer. The PDBNN can be effectively applied to all the three modules. It adopts a hierarchical network structures with nonlinear basis functions and a competitive credit-assignment scheme. The paper demonstrates a successful application of PDBNN to face recognition applications on two public (FERET and ORL) and one in-house (SCR) databases. Regarding the performance, experimental results on three different databases such as recognition accuracies as well as false rejection and false acceptance rates are elaborated. As to the processing speed, the whole recognition process (including PDBNN processing for eye localization, feature extraction, and classification) consumes approximately one second on Sparc10, without using hardware accelerator or co-processor.
Temporal complexity and software faults (2002)

Software developers use complexity metrics to predict development costs before embarking on a project and to estimate the likelihood of faults once the system is built. Traditional measures, however, were designed principally for sequential programs, providing little insight into the added complexity of concurrent systems or increased demands of real-time systems. For the purpose of predicting cost and effort of development, the CoCoMo model considers factors such as real-time and other performance requirements; for fault prediction, however, most complexity metrics are silent on concurrency. An outline for developing a measure of what we term temporal complexity, including significant and encouraging results of preliminary validation, is presented. 13 standard measures of software complexity are shown to define only two distinct domains of variance in module characteristics. Two new domains of variance are uncovered through 6 out of 10 proposed measures of temporal complexity. The new domains are shown to have predictive value in the modeling of software faults.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Negative transconductance in a resistive gate metal-semiconductor field-effect transistor (1989)

Negative transconductance is reported in a resistive gate metal-semiconductor field-effect transistor (MESFET) for the first time. The negative transconductance arises as a result of the negative differential mobility of electrons in the GaAs channel, and is adequately described by a simple equivalent circuit model. The experimental device is fabricated with a planar ion-implanted MESFET process, and shows promise as a microwave signal source for use in monolithic microwave integrated circuits.
Improvement of Neutral Lipid and Polyunsaturated Fatty Acid Biosynthesis by Overexpressing a Type 2 Diacylglycerol Acyltransferase in Marine Diatom Phaeodactylum tricornutum (2013)

Microalgae have been emerging as an important source for the production of bioactive compounds. Marine diatoms can store high amounts of lipid and grow quite quickly. However, the genetic and biochemical characteristics of fatty acid biosynthesis in diatoms remain unclear. Glycerophospholipids are integral as structural and functional components of cellular membranes, as well as precursors of various lipid mediators. In addition, diacylglycerol acyltransferase (DGAT) is a key enzyme that catalyzes the last step of triacylglyceride (TAG) biosynthesis. However, a comprehensive sequence-structure and functional analysis of DGAT in diatoms is lacking. In this study, an isoform of diacylglycerol acyltransferase type 2 of the marine diatom Phaeodactylum tricornutum was characterized. Surprisingly, DGAT2 overexpression in P. tricornutum stimulated more oil bodies, and the neutral lipid content increased by 35%. The fatty acid composition showed a significant increase in the proportion of polyunsaturated fatty acids; in particular, EPA was increased by 76.2%. Moreover, the growth rate of transgenic microalgae remained similar, thereby maintaining a high biomass. Our results suggest that increased DGAT2 expression could alter fatty acid profile in the diatom, and the results thus represent a valuable strategy for polyunsaturated fatty acid production by genetic manipulation.
Development of Robust Calibration Models Using Support Vector Machines for Spectroscopic Monitoring of Blood Glucose (2010)

Sample-to-sample variability has proven to be a major challenge in achieving calibration transfer in quantitative biological Raman spectroscopy. Multiple morphological and optical parameters, such as tissue absorption and scattering, physiological glucose dynamics and skin heterogeneity, vary significantly in a human population introducing nonanalyte specific features into the calibration model. In this paper, we show that fluctuations of such parameters in human subjects introduce curved (nonlinear) effects in the relationship between the concentrations of the analyte of interest and the mixture Raman spectra. To account for these curved effects, we propose the use of support vector machines (SVM) as a nonlinear regression method over conventional linear regression techniques such as partial least-squares (PLS). Using transcutaneous blood glucose detection as an example, we demonstrate that application of SVM enables a significant improvement (at least 30%) in cross-validation accuracy over PLS when measurements from multiple human volunteers are employed in the calibration set. Furthermore, using physical tissue models with randomized analyte concentrations and varying turbidities, we show that the fluctuations in turbidity alone causes curved effects which can only be adequately modeled using nonlinear regression techniques. The enhanced levels of accuracy obtained with the SVM based calibration models opens up avenues for prospective prediction in humans and thus for clinical translation of the technology.
Integrated Virtual Preparation and Commissioning: supporting formal methods during automation systems development (2016)

Virtual commissioning – the development and validation of industrial control systems against a simulation model – is attracting interest in the automotive industry. The main motivation for its use is that control systems can start to be integrated and tested before the construction of the physical system. In addition to this, the ability to continuously test can lead to increased reliability and enables better coping with late changes. At the same time, using formal methods during production preparation and control system design promise similar benefits. Formal methods however, are not seeing the same surge in interest – they are rarely used in the automotive industry. In this paper a framework is proposed, Integrated Virtual Preparation and Commissioning, where virtual commissioning models are used as a base for preparation and control system implementation assisted by formal methods. The extensive use of simulation in virtual commissioning allows computation results from formal methods to be continuously validated by visual inspection and using existing analysis tools (e.g. collision detection methods). The framework is applied in a case study, where the combination of a simulation model and a formal model is used as an aid in generating operation sequences for validation during production preparation. The resulting formal model can be used to study the behavior of the production system before a control system has been implemented.
Examination of the automated solute-independent calibration technique (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExamination of the automated solute-independent calibration techniqueCurtiss N. Renn and Robert E. SynovecCite this: Anal. Chem. 1989, 61, 17, 1915–1921Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ac00192a027https://doi.org/10.1021/ac00192a027research-articleACS PublicationsRequest reuse permissionsArticle Views28Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of NRG1 Gene Fusions in Solid Tumors (2019)

<i>NRG1</i> fusions can be detected at a low incidence across multiple tumor types with significant heterogeneity in fusion partner.<i>See related commentary by Dimou and Camidge, p. 4865</i>.
The pathogenicity of cationic proteins (1983)

A Symposium organized by the Queen Elisabeth Medical Foundation