gebhart/patrepeval huggingface dataset:
High-Glucose Stimulation of 64,000-<i>M</i>r Islet Cell Autoantigen Expression (1989)

This study examined the effect of various extracellular glucose concentrations on the expression of a previously described 64,000-Mr islet cell autoantigen associated with insulin-dependent diabetes mellitus. The protein was precipitated from patient serums incubated with Triton X-100 lysates of [35S]methionine-labeled rat pancreatic islets that had been cultured in 5, 11, or 28 mM glucose for 6 h or 3 days. In both types of experiment, 28 mM glucose was the most efficient stimulator of 64,000-Mr autoantigen production. In contrast, the class I antigens of the major histocompatibility complex, precipitated by a rabbit polyclonal antiserum, were not influenced by differences in glucose concentrations. Our data indicate that expression of islet cell antigens may be increased during the course of hyperglycemia and suggest that the functional activity of islet cells influences their antigenicity.
Macroblock-Level Rate-Distortion Optimization with Perceptual Adjustment for Video Coding (2008)

Experiments have been conducted based on the reference coder JM12.2 of H.264/AVC. Simulation results show that the subjective qualities of the decoded frames are improved without compromising PSNR. Fig.1. blow shows the subjective performance of the proposed scheme for 'Foreman' sequence. We can easily find that the perceptual quality of the detailed region (such as the wrinkles on the facial area) is significantly improved by comparing the two encoded frames. However, the distortion increased in the background is much less visually noticeable. And we have also performed subjective evaluation by inviting 20 people to be human observers for our experiment. 17 of them said there is an obvious improvement in video quality.
A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease (2000)

This study evaluated the anti-graft versus host disease (GVHD) potential of a combination of immunotoxins (IT), consisting of a murine CD3 (SPV-T3a) and CD7 (WT1) monoclonal antibody both conjugated to deglycosylated ricin A. In vitro efficacy data demonstrated that these IT act synergistically, resulting in an approximately 99% elimination of activated T cells at 10−8 mol/L (about 1.8 μg/mL). Because most natural killer (NK) cells are CD7+, NK activity was inhibited as well. Apart from the killing mediated by ricin A, binding of SPV-T3a by itself impaired in vitro cytotoxic T-cell cytotoxicity. Flow cytometric analysis revealed that this was due to both modulation of the CD3/T-cell receptor complex and activation-induced cell death. These results warranted evaluation of the IT combination in patients with refractory acute GVHD in an ongoing pilot study. So far, 4 patients have been treated with 3 to 4 infusions of 2 or 4 mg/m2 IT combination, administered intravenously at 48-hour intervals. The T1/2 was 6.7 hours, and peak serum levels ranged from 258 to 3210 ng/mL. Drug-associated side effects were restricted to limited edema, fever, and a modest rise of creatine kinase levels. One patient developed low-titer antibodies against ricin A. Infusions were associated with an immediate drop of circulating T cells, followed by a more gradual but continuing elimination of T/NK cells. One patient mounted an extensive CD8 T-cell response directly after treatment, not accompanied with aggravating GVHD. Two patients showed nearly complete remission of GVHD, despite unresponsiveness to the extensive pretreatment. These findings justify further investigation of the IT combination for treatment of diseases mediated by T cells.
Hypermethylation of CpG islands in the mouse asparagine synthetase gene: relationship to asparaginase sensitivity in lymphoma cells. Partial methylation in normal cells (2001)

We have sequenced the promoter region of the murine asparagine synthetase gene and examined its methylation profile in the CpG islands of L-asparaginase-sensitive 6C3HED cells (asparagine auxotrophs) and resistant variants (prototrophs). In the former, complete methylation of the CpG island is correlated with failure of expression of mRNA: cells of the latter possess both methylated and unmethylated alleles, as do cells of the intrinsically asparagine-independent lines L1210 and EL4. A similar phenomenon was seen in normal splenic cells of adult mice. This was age related: no methylation was found in weanlings, but up to 45% of gene copies in animals 18 weeks or older were methylated. It was also tissue related, with methylation occurring rarely in liver cells. The relationship of these changes to oncogenesis is considered.
Histomonas meleagridis (Protozoa: Trichomonadidae): Analysis of Growth Requirements In Vitro (2010)

Histomonads grew rapidly in Dwyer's medium, consisting of medium 199, chick embryo extract, serum, and rice powder, reaching a population size of about 5 x 10(5) in 3-4 days, followed by a rapid decline. Substitution of other cell culture media (L-15, MEM, or RPMI) for M199 was also satisfactory, except for Waymouth's medium, which produced a lower and later peak of growth. Omission of serum or rice rendered media unsuitable for growth. Bacteriological culture media did not support growth of histomonads. Media that included glucose were unsuitable because the pH of the cultures dropped to about 4. The effect of glucose on pH was due to the action of bacteria. Oxygen inhibited growth of histomonads. There was no growth when culture tubes were not capped tightly, regardless of the medium used. Histomonads grew well with rice flour, cornstarch, oat flour, rye flour, and buckwheat flour. Barley and blue corn meal were less satisfactory. It appeared that the requirements for growth of the lumen phase Histomonas meleagridis included a suitable physiological saline, serum (of any source), and a starch source (grain flour). Anaerobic conditions and a pH near neutral were best. Histomonads separated into pure cultures by flow cytometry would not grow without the inclusion of an unspecified species of bacteria.
Ontology-Based Automatic Annotation of Learning Content (2006)

This paper presents an ontology-based approach to automatic annotation of learning objects’ (LOs) content units that we tested in TANGRAM, an integrated learning environment for the domain of Intelligent Information Systems. The approach does not primarily focus on automatic annotation of entire LOs, as other relevant solutions do. Instead, it provides a solution for automatic metadata generation for LOs’ components (i.e., smaller, potentially reusable, content units). Here we mainly report on the content-mining algorithms and heuristics applied for determining values of certain metadata elements used to annotate content units. Specifically, the focus is on the following elements: title, description, unique identifier, subject (based on a domain ontology), and pedagogical role (based on an ontology of pedagogical roles). Additionally, as TANGRAM is grounded on an LO content structure ontology that drives the process of an LO decomposition into its constituent content units, each thus generated content unit is implicitly semantically annotated with its role/position in the LO’s structure. Employing such semantic annotations, TANGRAM allows assembling content units into new LOs personalized to the users’ goals, preferences, and learning styles. In order to provide the evaluation of the proposed solution, we describe our experiences with automatic annotation of slide presentations, one of the most common LO types.
希腊“有组织犯罪”研究 (2013)

“有组织犯罪”在希腊已有数百年的历史，至今仍给希腊带来严重成胁。希腊国内现有“有组织犯罪”的相关数据存在着很大的局限性，相关实证研究更是匮乏。为弥补这一缺陷，文章在对香烟黑市、赃车及其零部件市场、可卡因市场三个非法市场进行实证研究的基础上，对这些研究的主要结论进行了总结，而这些结论与现有官方以及媒体报道的“有组织犯罪”现状并不一致。
Envisioning communication from the edge (2004)

In mapping movements on the edge, we explore how scholars redefine the boundaries of what constitutes research and practice. In The Fortune at the Bottom of the Pyramid: Eradicating Poverty through Profits, a book that already promises to be one of the seminal business books of the 21 st century, C. K. Prahalad (2004) recounts his difficulties in finding a journal to publish the research that informed his book. Thanks to his earlier success with a prizewinning bestseller on more conventional business strategy, Competing for the Future (Hamel & Prahalad, 1994), Prahalad went on to find a book publisher despite the academic journal rejections. His efforts, we would argue, were powered by his Asian origins and his desire to apply his business knowledge to make a positive difference to people disempowered by living at the bottom of the economic pyramid.
Polymerization of Aniline by Auric Acid: Formation of Gold Decorated Polyaniline Nanoballs (2005)

Abstract Summary: We report a new method for the preparation of polyaniline nanoballs by using HAuCl 4 as an oxidizing agent. During the reaction, aniline is oxidized and forms polyaniline whilst the hydrogen tetrachloroaurate is reduced and forms gold nanoparticles. These gold nanoparticles are found to decorate the nanoballs. The resultant precipitate and corresponding TEM image of the gold‐nanoparticle covered polyaniline nanoball. magnified image The resultant precipitate and corresponding TEM image of the gold‐nanoparticle covered polyaniline nanoball.
Development of Line-shaped Optical System for Pulsed Green Laser Annealing System for Manufacturing of Low-Temperature Poly-Si TFT (2006)

We have developed a new optical system that transforms the circle profile beam generated with near Gaussian intensity distribution by a pulsed green laser (second harmonics of a Q-switched Nd: YAG laser) into a lineprofile beam. This transformed beam has uniform distribution to within 5% in the longitudinal direction, and is about 100 mm long and 40 μm wide. In the width direction, the laser beam is focused to the limited M2 value. For homogenization in the longitudinal direction, we employ a one dimensionnal waveguide plate type homogenizer. The laser beam is divided by waveguide plates, and the divided beams are overlapped on the surface of the works. We successfully reduced interference fringes by increasing the fixed optical pass difference beyond the inherent time and coherent length for every divided pair of adjacent beams under a controlled space coherent length.
Home-made success. Interview by Catharine Sadler. (2006)

Community matrons in Basildon, Essex are cutting hospital admissions by supporting older people with long-term conditions in their own homes.
Covalent and Noncovalent Dimers of the Cyanide-Resistant Alternative Oxidase Protein in Higher Plant Mitochondria and Their Relationship to Enzyme Activity (1993)

Evidence for a mixed population of covalently and noncovalently associated dimers of the cyanide-resistant alternative oxidase protein in plant mitochondria is presented. High molecular mass (oxidized) species of the alternative oxidase protein, having masses predicted for homodimers, appeared on immunoblots when the sulfhydryl reductant, dithiothreitol (DTT), was omitted from sodium dodecyl sulfate-polyacrylamide gel sample buffer. These oxidized species were observed in mitochondria from soybean (Glycine max [L.] Merr. cv Ransom), Sauromatum guttatum Schott, and mung bean (Vigna radiata [L.] R. Wilcz). Reduced species of the alternative oxidase were also present in the same mitochondrial samples. The reduced and oxidized species in isolated soybean cotyledon mitochondria could be interconverted by incubation with the sulfhydryl reagents DTT and azodicarboxylic acid bis(dimethylamide) (diamide). Treatment with chemical cross-linkers resulted in cross-linking of the reduced species, indicating a noncovalent dimeric association among the reduced alternative oxidase molecules. Alternative pathway activity of soybean mitochondria increased following reduction of the alternative oxidase protein with DTT and decreased following oxidation with diamide, indicating that electron flow through the alternative pathway is sensitive to the sulfhydryl/disulfide redox poise. In mitochondria from S. guttatum floral appendix tissue, the proportion of the reduced species increased as development progressed through thermogenesis.
Peroxide and Aldehyde Formation in the Photocatalyzed Oxidation of Nonionic Surfactants (1990)

The non-ionic surfactant p-nonylphenyl poly (oxyethylene) ether undergoes photodegradation in irradiated heterogeneous TiO2 dispersion. The intermediacy of peroxides, aldehydes, and carboxylic acids is observed in the photodegradation of the surfactant to CO2. Amounts of the formed intermediate compounds are influenced by pH of the reaction mixture.
Increased expression of pAKT is associated with radiation resistance in cervical cancer (2006)

Phosphorylated AKT (pAKT) is a major contributor to radioresistance in human cancers. The aim of this study was to investigate the association of pAKT expression and radiation resistance in cervical cancer. A retrospective review was made of the records of 27 women who received primary radiation therapy due to locally advanced cervical cancer (LACC) with FIGO stage IIB-IVA. Nine patients regarded as radiation resistant developed local recurrences with a median progression free interval of 9 months. Eighteen patients did not show local recurrences, and were regarded as a radiation-sensitive group. Using pretreatment paraffin-embedded tissues, we evaluated pAKT expression by immunohistochemistry. A significant association was found between the level of pAKT expression and local recurrence. Immunohistochemical staining for pAKT was significantly more frequent in the radiation-resistant than in the radiation-sensitive group (P=0.004). The mean progression-free survival was 86 months for patients with pAKT-negative staining (19 cases) and 44 months for patients with pAKT-positive expression (eight cases) (P=0.008). These results suggest that signalling from phosphatidylinositide 3-kinase/pAKT can lead to radiation resistance, and that evaluation of pAKT may be a prognostic marker for response to radiotherapy in LACC.
Handbook of Fluid Dynamics and Fluid Machinery (1996)

This definitive reference contains contributions from renowned global experts who discuss not only the new generation of fluid dynamics and machinery but classical topics as well. Volume One covers the basics; Volume Two describes advanced aspects such as computational fluid dynamics and fluid machinery; and Volume Three covers the applications of fluid dynamics. This set is illustrated with over 1,000 line drawings and tables.
The Component Fatty Acids and Glycerides of Castor Oil (1964)

Abstract Gas‐liquid chromatographic analysis of methyl esters of two samples of castor oil gave the following (as wt %): palmitate 1.2, 0.9; stearate 0.7, 1.2; arachidate 0.3, 0.2; hexadecenoate 0.2, 0.2; oleate 3.2, 3.3; linoleate 3.4, 3.7; linolenate 0.2, 0.2; ricinolE'ate 89.4, 89.0; and dihydroxystearate 1.4, 1.3. Oxidative cleavage of purified methyl ricinoleate indicated that the double bond was exclusively in the 9舑10 position. Castor oil glycerides were fractionated in a 100‐tube CCD apparatus using 90% ethanol and commercial hexane as solvents. Analysis of pooled fractions showed (as mole %) triricinolein 68.2, diricinoleins 28.0, mono‐ricinoleins 2.9 and nonricinoleins 0.9. These results coupled with lipase hydrolysis of the whole oil and of the fractions agree well with the distribution pattern proposed by Vander Wal.
Distribution of extra-framework cations and water molecules in synthetic high-silica (Na, Cs)-rho-zeolite (2013)

We determined the distribution of extra-framework cesium and sodium atoms, as well as water molecules in the cavities of synthetic high-silica (Si/Al = 3.7) (Na, Cs)-rho-zeolite (Cs3.2Na6.7H0.3[Al10.2Si37.8O96] · 41H2O, Im-3m, a = 14.979(1) Å) from X-ray powder diffraction data by applying the Rietveld and the maximum entropy methods. Extra-framework Cs and Na cations are found in α-cavities facing eight- and six-membered rings and in the center of the double aromatic ring D8R.
Time-Domain Analysis of a Wire Antenna Near Arbitrarily Shaped Conductor Bodies (2003)

A time domain electrical field integral equation (TDEFIE) is formulated for the problem of a thin wire antenna in the presence of conductor bodies, and this equation is solved by the method of time marching algorithm. The analysis is valid for any arbitrarily shaped, oriented and positioned wire antennas relative to arbitrarily shaped conductor bodies. Current at the excited point, input admittance and radiation pattern are given and agree with the results computed by the method in frequency domain.
Molecular cloning and characterization of a 21 kDa protein secreted from Trichinella pseudospiralis (2001)

Recombinant protein was produced from the cDNA library of Trichinella pseudospiralis , which seemed to form part of the excretory–secretory (ES) products. The library was constructed from cDNA of muscle larvae at 1 month post-infection, and immunoscreened with antibody against T. pseudospiralis ES products. A clone, designated Tp21-3, contained a cDNA transcript of 657 bp in length with a single open reading frame, which encoded 172 amino acids (19617 Da in the estimated molecular mass). The predicted amino acid sequence of clone Tp21-3 had a similarity of 76% to that of clone ORF 17.20 (GenBank under accession number U88239) from T. spiralis . The recombinant fusion proteins encoded by clone Tp21-3 were produced in an Escherichia coli expression system and affinity purified. On Western blotting analysis, Tp21-3 recombinant proteins migrated at 40 kDa and reacted to antibody against T. pseudospiralis ES products and T. pseudospiralis -infected sera. Sera were developed against Tp 21-3 recombinant proteins, which reacted to a single band migrating at 21 kDa in crude worm extract and ES products from T. pseudospiralis on Western blotting analysis, and reacted with stichocytes of T. pseudospiralis on immunohistochemical staining.
Interactions of Derivatives of Guanidinophenyiglycine and Guanidinophenylalanine with Trypsin and Related Enzymes (1980)

Journal Article Interactions of Derivatives of Guanidinophenyiglycine and Guanidinophenylalanine with Trypsin and Related Enzymes Get access Hideaki TSUNEMATSU, Hideaki TSUNEMATSU Department of Chemistry, Faculty of Science, Kyushu University 33Higashi-ku, Fukuoka, Fukuoka 812 Search for other works by this author on: Oxford Academic PubMed Google Scholar Satoru MAKISUMI Satoru MAKISUMI 1 Department of Chemistry, Faculty of Science, Kyushu University 33Higashi-ku, Fukuoka, Fukuoka 812 1To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 88, Issue 6, October 1980, Pages 1773–1783, https://doi.org/10.1093/oxfordjournals.jbchem.a133152 Published: 01 October 1980 Article history Received: 30 April 1980 Published: 01 October 1980
Thickness Dependence of Magneto-Optic Effects in Tb-Fe Film (1983)

In the investigation of amorphous rare earth-transition metal (RE-TM) thin films for magneto-optic (M-O) storage applications, optimization of Kerr effect enhancement using dielectric overcoating in a bilayer structure has been the subject of numerous theoretical calculations [1]. It has been generally assumed that the optical constants such as the refractive index, absorption coefficient and dielectric tensor of the M-O film are independent of the film thickness. However, in light of a recent report which shows a strong thickness dependence of magnetic hysteretic properties and Curie temperature of the Tb-Fe films due to variation in the microstructure [2], it is necessary to investigate experimentally the optical enhancement of the Kerr effect in media having varying RE-TM film thickness and compare that to the theoretical results.
Genetic and antigenic characterization of complete genomes of Type 1 Porcine Reproductive and Respiratory Syndrome viruses (PRRSV) isolated in Denmark over a period of 10 years (2013)

Porcine Reproductive and Respiratory Syndrome (PRRS) caused by the PRRS virus (PRRSV) is considered one of the most devastating swine diseases worldwide. PRRS viruses are divided into two major genotypes, Type 1 and Type 2, with pronounced diversity between and within the genotypes. In Denmark more than 50% of the herds are infected with Type 1 and/or Type 2 PRRSV. The main objective of this study was to examine the genetic diversity and drift of Type 1 viruses in a population with limited introduction of new animals and semen. A total of 43 ORF5 and 42 ORF7 nucleotide sequences were obtained from viruses collected from 2003 to February 2013. Phylogenetic analysis of ORF5 nucleotide sequences showed that the Danish isolates formed two major clusters within the subtype 1. The nucleotide identity to the subtype 1 protogenotype Lelystad virus (LV) spanned 84.9-98.8% for ORF5 and 90.7-100% for ORF7. Among the Danish viruses the pairwise nucleotide identities in ORF5 and ORF7 were 81.2-100% and 88.9-100%, respectively. Sequencing of the complete genomes, including the 5'- and 3'-end nucleotides, of 8 Danish PRRSV Type 1 showed that the genome lengths differed from 14,876 to 15,098 nucleotides and the pairwise nucleotide identity among the Danish viruses was 86.5-97.3% and the identity to LV was 88.7-97.9%. The study strongly indicated that there have been at least two independent introductions of Type 1 PRRSV in Denmark and analysis of the full genomes revealed a significant drift in several regions of the virus.
Antitumor Activity and Structural Relationships of Purine Derivatives and Related Compounds against Neoplasms in Experimental Animals (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntitumor Activity and Structural Relationships of Purine Derivatives and Related Compounds against Neoplasms in Experimental AnimalsRoland K. RobinsCite this: J. Med. Chem. 1964, 7, 2, 186–199Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://doi.org/10.1021/jm00332a014RIGHTS & PERMISSIONSArticle Views203Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Development of a Novel Vibration Polishing Method for Fiber Protrusion in Multi-fiber Connectors † (2003)

A novel ultrasonic vibration polishing method for multi-fiber connector with high precision has been developed by introducing a supplementary polishing ferrule between the fiber-ends and the ultrasonic vibrator. This method enables us to obtain effectively the desired fiber protrusion regardless of the materials used for the connector. Good and stable physical contact (PC) connection was achieved even in single-mode 12-fiber MPO connectors, and return loss and insertion loss remained stable during 500 cycles of reconnection. These results demonstrate that this polishing method is effective in achieving both sufficient fiber protrusion and good PC in multi-fiber connectors. The method can be applied in high-precision processing.