gebhart/patrepeval huggingface dataset:
Effects of low molecular weight glycoproteins in chronic hepatitis B. (1996)

We evaluated the effect of low molecular weight glycoproteins isolated from animal spleen (Polyerga) in ten patients with biopsy proven chronic HBV infection with ongoing replication.Polyerga was given intramuscularly trice weekly and orally 3 tablets daily for 24 weeks. The effect on viral replication was evaluated by measuring HBV-DNA and HBeAg in serum.In three out of ten, HDV-DNA became undetectable and ALT decreased (mean pre-treatment ALT 87.2 +/- 55.38SD, mean post-treatment ALT 62.6 +/- 41.86SD p = 0.026 t-test and Wilcoxon test p = 0.014). During the first month of Polyerga application transient increase of serum ALT was observed in 50%. In HBeAg negative patients and in patients with low pre-treatment level of HBV-DNA (below 250pg/ml) there was significant decrease of ALT by t-test (p = 0.022), Wilcoxon (p = 0.028) and Sign test (p = 0.041) in contrast to those with HBV-DNA above 250pg/ml.The effect of increasing the cytolysis shows that these drugs are active, probably by increasing the lymphokine secretion and the generation of cytotoxic T-cells. The absence of side effects, its ability to reduce viral replication and lower ALT activity even in patients with liver cirrhosis warrants further studies as a "second drug" or as a drug of choice when IFN is contraindicated.
CTXφ Infection of <i>Vibrio cholerae</i> Requires the <i>tolQRA</i> Gene Products (2000)

CTXphi is a lysogenic filamentous bacteriophage that encodes cholera toxin. Filamentous phages that infect Escherichia coli require both a pilus and the products of tolQRA in order to enter host cells. We have previously shown that toxin-coregulated pilus (TCP), a type IV pilus that is an essential Vibrio cholerae intestinal colonization factor, serves as a receptor for CTXphi. To test whether CTXphi also depends upon tol gene products to infect V. cholerae, we identified and inactivated the V. cholerae tolQRAB orthologues. The predicted amino acid sequences of V. cholerae TolQ, TolR, TolA, and TolB showed significant similarity to the corresponding E. coli sequences. V. cholerae strains with insertion mutations in tolQ, tolR, or tolA were reduced in their efficiency of CTXphi uptake by 4 orders of magnitude, whereas a strain with an insertion mutation in tolB showed no reduction in CTXphi entry. We could detect CTXphi infection of TCP(-) V. cholerae, albeit at very low frequencies. However, strains with mutations in both tcpA and either tolQ, tolR, or tolA were completely resistant to CTXphi infection. Thus, CTXphi, like the E. coli filamentous phages, uses both a pilus and TolQRA to enter its host. This suggests that the pathway for filamentous phage entry into cells is conserved between host bacterial species.
An Application of the Boostrap Method to the Simultaneous Equations Model of the Demand and Supply of Audit Services* (1998)

Abstract This paper extends the application of the bootstrap method in accounting research to a simultaneous equations model of the demand and supply of audit services with mixed qualitative and continuous dependent variables. A moderately sized sample of 118 quality control reviews (Copley, Doucet, and Gaver 1994) is used to demonstrate the bootstrap method and compare results to estimates of standard errors obtained from Amemiya's 1978 asymptotic generalized least squares (GLS) procedure. We find that the GLS t ‐statistics are inflated by as much as 55 percent and the corresponding p ‐values are likewise overstated when compared to the bootstrap results. The problem is more acute with the qualitative dependent variable for audit quality, which is often the key variable of interest.
Childhood trauma and risk for PTSD: Relationship to intergenerational effects of trauma,parental PTSD, and cortisol excretion (2001)

Among the adverse mental health consequences of childhood trauma is the risk related to the development of posttraumatic stress disorder (PTSD) in adulthood. Other risk factors for PTSD. including parental trauma exposure and parental PTSD, can also contribute to the experience of child trauma. We examined associations between childhood trauma and PTSD in 51 adult children of Holocaust survivors and 41 comparison subjects. in consideration of parental trauma exposure and parental PTSD. We also examined these variables in relation to 24-hr urinary cortisol levels. Adult offspring of Holocaust survivors showed significantly higher levels of self-reported childhood trauma, particularly emotional abuse and neglect. relative to comparison subjects. The difference was largely attributable to parental PTSD. Self-reported childhood trauma was also related to severity of PTSD in subjects, and emotional abuse was significantly associated with 24-hr mean urinary cortisol secretion. We conclude that the experience of childhood trauma may be an important factor in the transmission of PTSD from parent to child.
Theoretical mechanics of particles and continua (1980)

This two-part text fills what has often been a void in the first-year graduate physics curriculum. Through its examination of particles and continua, it supplies a lucid and self-contained account of classical mechanics - which in turn provides a natural framework for introducing many of the advanced mathematical concepts in physics.The text opens with Newton's laws of motion and systematically develops the dynamics of classical particles, with chapters on basic principles, rotating coordinate systems, lagrangian formalism, small oscillations, dynamics of rigid bodies, and hamiltonian formalis
Tape recorder Patent (1969)

Tape recorder designed for low power consumption and resistance to operational failure under high stress conditions
[1,2,3]Triazoloazine/(Diazomethyl)azine Valence Tautomers from 5‐Azinyltetrazoles (1978)

Abstract [1,2,3]Triazoloazines are formed by thermolysis of 5‐azinyltetrazoles in the gasphase or in solution. Thus, 5‐(2‐pyridyl)tetrazole ( 7 ) and 5‐(2‐pyrazinyl)tetrazole ( 11 ) yield [1,2,3]triazolo[1,5‐ a ]pyridine ( 9 ) and [1,2,3]triazolo[1,5‐ a ]pyrazine ( 13 ), respectively, at 400°/10 −3 ‐ 10 −5 Torr. 5‐(2‐Phenyl‐4‐quinazolinyl)tetrazole ( 15 ) gives 5‐phenyl[1,2,3]triazolo[1,5‐ c ]quinazoline ( 17 ) in 75% yield by heating under reflux in mesitylene solution. 2‐(Diazomethyl)pyridine ( 8 ), a valence tautomer of 9 , can be trapped by fumaronitrile, leading to 3‐(2‐pyridyl)‐1, 2‐cyclopropanedicarbonitrile ( 19 ). The [1,2,3]triazoloazines undergo base catalysed H/D‐exchange in D 2 O solution.
A Statistical Bit Error Generator for Emulation of Complex Forward Error Correction Schemes (2007)

Forward error correction (FEC schemes are generally used in wireless communication systems to maintain an acceptable quality of service. Various models have been proposed in literature to predict the end-to-end quality of wireless video systems. However, most of these models utilize simplistic error generators which do not accurately represent any practical wireless channel. A more accurate way is to evaluate the quality of a video system using Monte Carlo techniques. However these necessitate huge computational times, making these methods unpractical. This paper proposes an alternative method that can be used in modeling of complex communications systems with minimal computational time. The proposed three random variable method was used to model two FEC schemes adopted by the digital video broadcasting (DVB) standard. Simulation results confirm that this method closely matches the performance of the considered communication systems in both bit error rate (BER) and peak signal-to-noise ratio (PSNR).
OSCAR: a system for weak-consistency replication (2002)

The proliferation of internetworks and distributed applications has increased the demand for geographically distributed replicated databases. The traditional approach of strong consistency is difficult to achieve across an internetwork. In contrast to strong consistency, a database replication system that provides weak consistency permits greater availability by allowing temporary inconsistencies to develop among the replicas. The Open System for Consistency and Replication (OSCAR), an architecture for a weak-consistency replication system, is presented. The approach to reliable replication is to use two complementary mechanisms. When an update initially enters the replication system, it is unreliably pushed to all other replicas. A novel technique called mediation ensures reliable propagation of the updates throughout the system. OSCAR provides appropriate weak consistency for a variety of applications by simultaneously supporting several weak-consistency methods. Its modular design permits its components to be configured for different networks and allows its algorithms to be selected and tuned for different environments and applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Current Information Technology Activities At The National Library Of Australia (1997)

Summarises developments in information technology and technology-intensive services at the National Library of Australia (NLA) during 1996 and early 1997. Outlines progress made with the Network Services Project (NSP), Stage 1 of which will provide a national bibliographic utility system, a cataloguing client, a gateway server, a national interlibrary loan utility and an administrative support system. Other activities described include work on the development of an international union catalogue profile, launch of the National CJK (Chinese, Japanese, Korean) Service, and developments in the Australian Bibliographic Network (ABN). Outlines work on the Register of Australian Archives and Manuscripts (RAAM), the NLA Web site, metadata and major digitising projects in progress or planned.
Emerging drugs for diabetic macular edema (2014)

Pharmacologic treatment of DME will likely become increasingly used, especially for patients with edema involving the fovea. At this time, the two main classes of medication for treatment of DME are anti-VEGF agents and corticosteroids. As we continue to collect clinical trials data, the precise role of individual agents, and the continuing role for photocoagulation, will become more clear.
Symbolic bounds analysis of pointers, array indices, and accessed memory regions (2005)

This article presents a novel framework for the symbolic bounds analysis of pointers, array indices, and accessed memory regions. Our framework formulates each analysis problem as a system of inequality constraints between symbolic bound polynomials. It then reduces the constraint system to a linear program. The solution to the linear program provides symbolic lower and upper bounds for the values of pointer and array index variables and for the regions of memory that each statement and procedure accesses. This approach eliminates fundamental problems associated with applying standard fixed-point approaches to symbolic analysis problems. Experimental results from our implemented compiler show that the analysis can solve several important problems, including static race detection, automatic parallelization, static detection of array bounds violations, elimination of array bounds checks, and reduction of the number of bits used to store computed values.
Inverse matrix modification lemma and Thevenin theorem for compensated network solutions (1999)

The close relationship between the inverse matrix modification lemma (IMML) and the Thévenin theorem is investigated. Making reference to the modified network solution by compensation, the IMML formula is demonstrated using the Thévenin theorem (or its dual Norton theorem) and superposition. Such equivalence allows either approach to be applied to network modification cases with the same computation burden. However, the Thévenin–Norton approach leads to a reduced number of operations compared to IMML in those contingency cases involving solid connections (bus join). Examples of the compensation procedure based on the Thévenin–Norton approach are given with reference to IEEE and to actual large-scale power networks.
<i>Thiobacillus acidophilus</i> sp. nov.; isolation and some physiological characteristics (1975)

After a brief exposition to glucose, Thiobacillus acidophilus was isolated from a culture of iron-grown T. ferrooxidans. Physicochemical analysis of its DNA showed a G+C content of 62.9-63.2%. The new isolate grows best at 25-30 degrees C and at pH 3.0. Growth is possible between pH 1.5 and 6.0. Thiobacillus acidophilus is apparently strictly aerobic. Ammonium salts are the only suitable source of nitrogen. The bacterium is a facultative autotroph. In addition to elemental sulfur, it obtains energy from organic compounds such as D-glucose, D-galactose, D-fructose, D-mannitol, D-xylose, D-ribose, D-arabinose, L-arabinose, sucrose, sodium citrate, malic acid,dl-aspartic acid, and dl-glutamic acid. Thiobacillus acidophilus possesses the key enzymes of the tricarboxylic acid (TCA) cycle including NAD-and NADP-linked isocitric dehydrogenase and alpha-ketoglutarate dehydrogenase, and the key enzymes of the hexose monophosphate pathway (glucose-6-phosphate and 6-phosphogluconate dehydrogenase, and fructose 1,6-diphosphate aldolase). NADH oxidase has been found in particulate fraction of extracts. Rhodanese and thiosulfate oxidase have also been detected.
A Classification of 148 U.S. Maize Inbreds: I. Cluster Analysis Based on RFLPs (1994)

Knowledge of relationships among lines is essential to the maize ( Zea mays L.) breeder because it directs the exploitation of germplasm in hybrid production. Restriction fragment length polymorphism (RFLP) data should be useful for estimating relationships among inbreds because they reflect differences in the DNA sequence. Cluster analysis, based on RFLPs resulting from 46 probe‐enzyme combinations, was used to reveal associations among 148 U.S. maize inbreds and assign inbreds to heterotic groups. Estimates of genetic relationship between all pairs of inbreds were computed by Gower's Coefficient of Similarity and expressed as Euclidean distances. Then, these estimates were used to assign inbreds to groups by the average linkage method (UPGMA). Differences in the hybridization fragments exhibited lines within and between groups were evaluated to explore the basis for partitioning the fines. In the cluster analysis, inbreds were ordered into two major groups generally coinciding with distinctions between breeding groups derived from ‘Lancaster Sure Crop’ open pollinated variety and from Iowa Stiff Stalk Synthetic. Within these two groups, 11 subgroups were formed, each containing lines associated with an elite inbred (WF9, MO17, C103, PA91, OH43, T8, B14, B73, N28, B37, or OH07). The classification generally agreed with pedigree information and was supported by principal component analysis. Groups differed markedly in the proportions of lines exhibiting particular fragments. However, differences between groups reflected differences in frequencies rather than distinctions between the presence or absence of fragments by the vast majority of the lines in the respective groups.
TT2, TT8, and TTG1 synergistically specify the expression of <i>BANYULS</i> and proanthocyanidin biosynthesis in <i>Arabidopsis thaliana</i> (2004)

Genetic analyses have demonstrated that together with TTG1, a WD-repeat (WDR) protein, TT2 (MYB), and TT8 (bHLH) are necessary for the correct expression of BANYULS (BAN). This gene codes for the core enzyme of proanthocyanidin biosynthesis in Arabidopsis thaliana seed coat. The interplays of TT2, TT8, and their closest MYB/bHLH relatives, with TTG1 and the BAN promoter have been investigated using a combination of genetic and molecular approaches, both in yeast and in planta. The results obtained using glucocorticoid receptor fusion proteins in planta strongly suggest that TT2, TT8, and TTG1 can directly activate BAN expression. Experiments using yeast two- and three-hybrid clearly demonstrated that TT2, TT8, and TTG1 can form a stable ternary complex. Furthermore, although TT2 and TT8 were able to bind to the BAN promoter when simultaneously expressed in yeast, the activity of the complex correlated with the level of TTG1 expression in A. thaliana protoplasts. In addition, transient expression experiments revealed that TTG1 acts mainly through the bHLH partner (i.e. TT8 or related proteins) and that TT2 cannot be replaced by any other related A. thaliana MYB proteins to activate BAN. Finally and consistent with these results, the ectopic expression of TT2 was sufficient to trigger BAN activation in vegetative parts, but only where TTG1 was expressed. Taken together, these results indicate that TT2, TT8, and TTG1 can form a ternary complex directly regulating BAN expression in planta.
Use of Phage Display Libraries to Select For B-cell Receptor-specific Peptides of Chronic Lymphocytic Leukemia Cells (2012)

Use of Phage Display Libraries to Select For B-cell Receptor-specific Peptides of Chronic Lymphocytic Leukemia Cells
Common Pavement Structure Disease Prevention and Treatment Technique in Plain Area (2010)

After the causes and characteristics of pavement diseases of common pavement structure in plain area are analyzed,one technique of draining free water from pavement structure layer.Maintenance practice has proved its effect.It has popularization and practical significance to pavement maintenance.
Susceptibility of Naegleria fowleri to delta 9-tetrahydrocannabinol (1979)

Growth of the pathogenic amoeboflagellate Naegleria fowleri is inhibited by delta 9-tetrahydrocannabinol (delta 9-THC). delta 9-THC is amoebostatic at 5 to 50 micrograms/ml. delta 9-THC prevents enflagellation and encystment, but does not impair amoeboid movement. Calf serum at 10 and 20% (vol/vol) reduces the antiamoeba activity of delta 9-THC. Only 1-methoxy delta 8-tetrahydrocannabinol, of 17 cannabinoids tested, failed to inhibit growth of N. fowleri. Antinaeglerial activity was not markedly altered by opening the pyran ring, by converting the cyclohexyl ring to an aromatic ring, or by reversing the hydroxyl and pentyl groups on the benzene ring. delta 9-THC prevented the cytopathic effect of N. fowleri on African green monkey (Vero) cells and human epithelioma (HEp-2) cells in culture. delta 9-THC afforded modest protection to mice infected with N. fowleri.
Galactic Evolution with the Space Telescope (1979)

Some aspects of research on galactic evolution with the Space Telescope (ST) are discussed. Viewpoints are provided from which ST (and related ground based) studies can be planned.
The use of biotinylated DNA probes in parentage testing: Non‐isotopic labeling and non‐toxic extraction (1988)

With a few exceptions DNA probing techniques require the use of radioisotopes and toxic DNA extraction techniques which render the method expensive, potentially hazardous and time-consuming. Most isotopic labeling techniques use the isotope 32P and require 3-10 days to visualize bands after hybridization. An alternative approach is based on the use of non-isotopic detection methods. The available non-isotopic techniques were assessed and their practicality tested. All probes analyzed were tested on samples extracted with a non-toxic extraction procedure using 6 M NaCl as the substitute for phenol and isochloroform. By manipulating probe sizes, blocking agents, selection of membrane and detection system, it is feasible to use non-isotopic labeling and detection in routine parentage testing. Reproducible results were obtained with labeling a variety of DNA probes of various sizes, plasmid and inserts. With an absence of waste disposal costs, probes that are stable for over two years and a staining procedure which takes 3-5 h versus days the technique is well suited for a normal laboratory setting. The next key to the acceptability of DNA testing will be the commercial availability of DNA probes for widespread use.
Official Netscape Communicator 4 book (1997)

From the Publisher:

Ventana's Official Netscape Communicator 4 Book covers all features in the suite: Navigator 4.0, Collabra, Composer, Conference, Messenger and Netcaster. The book is filled with real-world techniques and examples to increase productivity and ease workgroup collaboration from creating Web pages with wizards and templates to disseminating newsletters and other office information. It also features a foreword written by the founder of Netscape Communications Corp., Marc Andreessen.
The only official Netscape title.
Provides step-by-step instructions for both intranet and Internet tasks.
Shows how to customize your browser, and add shortcuts and bookmarks.
Contains tips and techniques to increase productivity and enhance workgroup collaboration.
Includes dozens of the most innovative and informative sites on the Web!
Communicator 4.0
Hyperlinked version of the author's favorite Net resources chapter from the book
Phenotypic and genotypic profiling of antimicrobial resistance in enteric <i>Escherichia coli</i> communities isolated from finisher pigs in Australia (2016)

The use of registered antimicrobials in Australian pigs leads to the enteric commensal populations acquiring associated ARGs. However, despite a high intensity of sampling, ARGs imparting resistance to the critically important 3rd-generation cephalosporins were not detected.
Aligned and exchange-coupled FePt-based films (2011)

Two-phase nanostructures of hard L10-ordered FePt and soft iron-rich fcc Fe-Pt are investigated experimentally and by model calculations. The Fe-Pt thin films were produced by epitaxial co-sputtering onto MgO and have a thickness of about 10 nm. They form two-phase dots that cover a large fraction of the surface but are separated from each other. X-ray diffraction and TEM show that the c-axis of the phase FePt is aligned in the direction normal to the film plane. The experimental and theoretical hysteresis loops indicate archetypical exchange coupling, and excellent magnetic properties are obtained. The largest values of coercivity, saturation magnetization, and nominal energy product obtained in the samples studied are 51 kOe, 1287 emu/cc, and 54 MGOe, respectively.
Pathogenesis of Chronic Chagas Heart Disease (2007)

Most clinical studies have been performed in very small number of patients. Future research should explore the clinical potential implications and therapeutic opportunities of these 2 fundamental underlying pathogenetic mechanisms.
Genomic and Coexpression Analyses Predict Multiple Genes Involved in Triterpene Saponin Biosynthesis in <i>Medicago truncatula</i>   (2010)

Saponins, an important group of bioactive plant natural products, are glycosides of triterpenoid or steroidal aglycones (sapogenins). Saponins possess many biological activities, including conferring potential health benefits for humans. However, most of the steps specific for the biosynthesis of triterpene saponins remain uncharacterized at the molecular level. Here, we use comprehensive gene expression clustering analysis to identify candidate genes involved in the elaboration, hydroxylation, and glycosylation of the triterpene skeleton in the model legume Medicago truncatula. Four candidate uridine diphosphate glycosyltransferases were expressed in Escherichia coli, one of which (UGT73F3) showed specificity for multiple sapogenins and was confirmed to glucosylate hederagenin at the C28 position. Genetic loss-of-function studies in M. truncatula confirmed the in vivo function of UGT73F3 in saponin biosynthesis. This report provides a basis for future studies to define genetically the roles of multiple cytochromes P450 and glycosyltransferases in triterpene saponin biosynthesis in Medicago.