gebhart/patrepeval huggingface dataset:
Analysis of RNA associated with P granules in germ cells of <i>C. elegans</i> adults (2001)

ABSTRACT P granules are cytoplasmic structures of unknown function that are associated with germ nuclei in the C. elegans gonad, and are localized exclusively to germ cells, or germ cell precursors, throughout the life cycle. All the known protein components of P granules contain putative RNA- binding motifs, suggesting that RNA is involved in either the structure or function of the granules. However, no specific mRNAs have been identified within P granules in the gonad. We show here that P granules normally contain a low level of RNA, and describe conditions that increase this level. We present evidence that several, diverse mRNAs, including pos-1, mex-1, par-3, skn-1, nos-2 and gld- 1 mRNA, are present at least transiently within P granules. In contrast, actin and tubulin mRNA and rRNA are either not present in P granules, or are present at relatively low levels. We show that pgl-1 and the glh (Vasa-related) gene family, which encode protein components of P granules, do not appear essential for RNA to concentrate in P granules; these proteins may instead function in events that are a prerequisite for RNAs to be transported efficiently from the nuclear surface.
Several Suggestions of Increasing Farmer Income and Improving Competitiveness of Agricultural Products at New Stage (2003)

The key problem that restricting agriculture and rural development at present mainly is how to increase farmer income and improve competitiveness of agricultural products. Thus, the suggestions that the author has put forward to solve as follows: Adjusting the national agricultural policy; Strengthening government's support to agriculture; Accelerating the spare workforce's transformation in the countryside-areas; Improving farmer organization; Re-structuring government agricultural management organization and function; improving the competitiveness of agricultural products through applications of scientific and technical innovation to agriculture.
ASSOCIATION OF THE CYCLIN D1 GENE <i>G</i> 870 <i>A</i> POLYMORPHISM WITH SUSCEPTIBILITY TO SPORADIC RENAL CELL CARCINOMA (2004)

These data suggest that the CCND1 variant A allele may be a genetic susceptibility factor with a recessive or gene dose effect for the onset of sporadic RCC. More extensive and larger studies are required to clarify whether the CCND1 genotype is more specifically involved in the onset of a histological subset of RCC or RCC at a younger age.
The characteristics of alpha particle effects on 64K CCD's (1979)

The sensitivity of commercially available 64K CCD devices to α particles has undergone a systematic study. The circuit and methods employed for the study are described. The variations of sensitivity with α flux, α energy, circuit frequency, circuit voltage, and data pattern is presented. Data is also discussed relating to the variation from device to device.
Hepatic Nuclear Factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse (1991)

Hepatic nuclear factor 1 (HNF1) is a highly diverged homeoprotein that is crucial for transcription of many liver-specific genes including albumin. In particular, a minimal promoter, consisting of an HNF1-binding-site and a TATA box, is highly active only in hepatoma cell lines. The expression of the HNF1 and albumin genes has been examined in mouse embryos by in situ hybridization. At 10.5 days of gestation, the HNF1 mRNA was detected in both the hepatic primordia and visceral endoderm of the yolk sac whereas the albumin transcript was present only in the nascent liver. At later stages of development, HNF1 was detected in liver, in the epithelial cells of most of the digestive tract and in the cortex of the kidney, whereas albumin was again found only in the liver. The presence of HNF1 protein in adult kidney was demonstrated by immunodetection in gel-retardation assays and western blot analysis. These experiments show that, even though the HNF1 homeo-protein is essential for expression of many liver-specific genes, it cannot, by itself, force high expression levels of these genes, in non-hepatic tissues.
Genome-wide Analysis of Pre-mRNA 3′ End Processing Reveals a Decisive Role of Human Cleavage Factor I in the Regulation of 3′ UTR Length (2012)

Through alternative polyadenylation, human mRNAs acquire longer or shorter 3' untranslated regions, the latter typically associated with higher transcript stability and increased protein production. To understand the dynamics of polyadenylation site usage, we performed transcriptome-wide mapping of both binding sites of 3' end processing factors CPSF-160, CPSF-100, CPSF-73, CPSF-30, Fip1, CstF-64, CstF-64τ, CF I(m)25, CF I(m)59, and CF I(m)68 and 3' end processing sites in HEK293 cells. We found that although binding sites of these factors generally cluster around the poly(A) sites most frequently used in cleavage, CstF-64/CstF-64τ and CFI(m) proteins have much higher positional specificity compared to CPSF components. Knockdown of CF I(m)68 induced a systematic use of proximal polyadenylation sites, indicating that changes in relative abundance of a single 3' end processing factor can modulate the length of 3' untranslated regions across the transcriptome and suggesting a mechanism behind the previously observed increase in tumor cell invasiveness upon CF I(m)68 knockdown.
Microcarriers and Their Potential in Tissue Regeneration (2010)

Microcarriers are a versatile tool with applications across a wide range of disciplines within tissue engineering. Large numbers of cells of appropriate phenotypes are required in engineering the many different tissues of the body, and microcarriers facilitate not only the expansion of many cell types but also the investigation of cell behavior in vitro. Microcarriers can also be used to directly deliver cells in vivo to repair and regenerate tissues. This review summarizes and discusses the use of microcarriers in diverse applications of tissue repair, including bone, cartilage, skin, vascular, central nervous system, adipose tissue, and liver repair. It also considers how microcarriers can be used to bulk-culture and deliver stem cells for tissue regeneration. Microcarriers thus have multidisciplinary use and advances in their use are of benefit to the entire tissue engineering field.
Comparative Properties of Insulin‐like Growth Factor 1 (IGF‐1) and [Gly7D‐Ala]IGF‐1 Prepared by Total Chemical Synthesis (2007)

Chemistry for biology: IGF-1 and [Gly7D-Ala]IGF-1 have been prepared by a total chemical synthesis and their folding and receptor-binding properties compared (see scheme). This approach facilitates the introduction of nonstandard amino acids whose biosynthetic incorporation is difficult or not feasible and thus promises to lead to a new generation of structure–activity studies of potential interest in the treatment of cancer and diabetes mellitus. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703521_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Novel Modulator of Na<sub>V</sub>1.1 and Na<sub>V</sub>1.2 Na<sup>+</sup>Channels in Rat Neuronal Cells (2010)

A novel modulator of sodium ion currents was synthesized in 6 steps from a protected dihydroxypyrrolidine nitrone, via 1,3-dipolar cycloaddition reaction with acrylamide. Sodium ion currents in B50 cells were evaluated in comparison to saxitoxin and tetrodotoxin, and revealed an IC(50) of 15.7 muM. The new compound shows no evidence of binding to the C-lobe of the saxitoxin-binding protein saxiphilin.
Prediksi Penerimaan Beasiswa Santri Pada Lembaga Pendidikan di Pesantren Nurul Huda Menggunakan Algoritma J48 (2017)

Dalam penelitian ini membahas tentang bagaimana memprediksi penerimaan Beasiswa santri pada lembaga pendidikan di Pesantren Nurul Huda Dengan Algoritma J48, salah satu kendala yang ada pada lembaga pendidikan Pesantren Nurul Huda adalah tentang penerima beasiswa santri yang kadang kala tidak tepat saran karena penentuan beasiswanya menggunakan instuisi manusia yang terkadang terjadi human error, penelitian ini mencoba membuatkan sebuah aplikasi data mining yang bisa memprediksikan penerima beasiswa agar lebih tepat saran dalam menentukan penerima beasiswa santri dengan algoritma J48 yang terintegrasi dengan Java Virtual Mesin (JVM) dan menggunakan Lib Weka, hal yang perlu diperhatikan dalam memprediksi adalah akurasi data semakin tinggi akurasi data maka semakin tepat prediksi penerimaan beasiswanya, data yang akan digunakan dalam penelitian berjumlah 1635 santri, adapun atribut yang akan digunakan dalam penelitian ini meliputi pendapatan orang tua, pekerjaan orang tua, pendidikan orang tua, dan status santri(Yatim,Yatim Piatu, Tidak), dengan akurasi mencapai 87%Kata kunci: Klasifikasi data mining, Beasiswa Santri, J48
Analyzing Home Automation and Networking Technologies (2018)

Due to the rapid advancements in networking and automation technologies, the concept of smart homes has started taking shape. AT&T Digital Life, Schneider's Wiser homes, and Qualcomm's M2M communication, among others, are examples of ventures by conglomerates into the business of home automation. Three-quarters of homes in the United States possess computers, and more than two-thirds of those are connected to the Internet. Wireless networking in the form of Wi-Fi is present in 17% of homes.
Microstructural evolution induced by scanned laser annealing in Al interconnects (1999)

A method has been developed for inducing controlled microstructural evolution in thin films patterned into lines, using scanned laser annealing (SLA). Experimental studies show at least three distinct types of microstructures resulting from SLA, depending on the scan rate and laser power. Starting with a polygranular initial microstructure, scanned laser annealing leads to either a large-grained polygranular structure, a bamboo structure, or an agglomerated structure. Microstructural evolution induced by SLA was found to lead to different evolution than conventional annealing, as well as to produce unique large-grained “bamboo” structures. Simulations of SLA further suggest the possibility of producing near-single crystal microstructures under properly controlled conditions.
Dynamic control of auditory activity during sleep: Correlation between song response and EEG (2001)

The song nucleus high vocal center (HVC) sends neural signals for song production and receives auditory input. By using electroencephalography (EEG) to objectively identify wake/sleep state, we show that HVC auditory responses change with physiological states. Comparison of EEG and HVC records revealed that HVC response to auditory stimuli is greatest during slow-wave sleep. During slow-wave sleep, HVC neurons responded preferentially to the bird's own song. Strikingly, both spontaneous and forced waking during sleep caused HVC auditory responses to cease within milliseconds of an EEG-measured state change. State-dependent phenomena in downstream nuclei, such as robustus archistriatalis, are likely to be derivatives of those in HVC.
Principal Component Analysis of Wind Profiler Observations (1997)

Principal component analysis (PCA) is applied to wind profiler observations to study the vertical profile of the wind field and its temporal evolution. The rationale for decomposing time–height wind profiler data using PCA is twofold. The orthogonal vertical profile vectors are determined empirically from the variance of the observations, and the time evolutions of these vectors are not simple sinusoids, but are temporal varying signals that can be directly related to other measurements. As an example of its utility, PCA is used to compare the annual and interannual variation of zonal wind measured with a 50-MHz VHF wind profiler above Christmas Island, Kiribati, with the difference between surface pressures measured at Tahiti, French Polynesia, and Darwin, Australia. The high correlation coefficients relate the vertical profile of zonal wind observed in the central Pacific with the variation of convection in the western Pacific. Complex PCA (C-PCA) allows the analysis of data consisting of amplitude and phase information. It can describe the phase progression of oscillations embedded within the data. The C-PCA is applied to VHF wind profiler observations to study the seasonal behavior of the diurnal meridional wind observed above Biak, Indonesia, and the oscillatory structures of the vertical wind during a convective precipitation event observed above Darwin.
probGRV: a workflow for geostatistical depth conversion and probabilistic assessment of gross rock volume (2014)

Understanding and estimating the probability of geological success (Pg) and original hydrocarbon-in-place (OHIP) are an integral part of the geoscientist’s role from exploration though to development. This paper presents a workflow developed at Santos for the systematic assessment of two key elements in this process: the probability of structural closure (Pcl); and, the estimation of the uncertainty of gross rock volume (GRV). There are two distinct parts to the workflow. Firstly, Kriging and sequential Gaussian simulation (SGS) are used in map-based, seismic time-to-depth conversion to generate multiple equi-probable depth maps (in the order of 1,000+ realisations). Numerous depth conversion methods are considered where appropriate. Secondly, every depth map realisation is validated for structural closure around a target location (e.g. a proposed or existing well). Primary outputs from the workflow include estimates of Pcl, and probability distributions of GRV and pool area for valid maps, which may then be used directly in estimating geological risk and OHIP. Secondary outputs from the workflow include basic statistics associated with depth conversion uncertainty, such as target depth prognosis and the distribution of the depth to lowest closing contour. The ultimate objective is to provide the interpreter with a greater appreciation of the range of possible outcomes given the uncertainty in structural geometry. This workflow, named probGRV, has been designed and developed within Santos using commercially available geophysical software and in-house proprietary software. During the past few years, the workflow has been implemented on key assets at various stages of the prospect/field life cycle and in both pre- and post-drilling campaigns for audit purposes. Case studies from the Cook Field in the onshore Eromanga Basin and the Finucane South Field in the offshore Carnarvon Basin are shown to illustrate the methods and results.
Purification of High Aspect Ratio Gold Nanorods: Complete Removal of Platelets (2008)

Because physical and chemical properties of nanostructures strongly depend on their shape, it is of great importance to find either synthetic or separation techniques that can produce objects of a particular shape in a pure state. This manuscript describes a solution to a long standing problem of separating 2D platelets from 1D nanorods. The key aspect of our approach relies on the partial dissolution of faceted platelets with Au(III)/CTAB complex that transforms them into smaller nanodisks. Because of the reduction in size, the 2D structures become fully soluble in water and can be separated from the nanorods that undergo slow precipitation. In addition, the isolated nanodisks can be converted back into initial faceted platelets upon treatment with Au(I)/ascorbic acid mixture. As a result of these simple procedures, a seemingly inseparable mixture of rods, platelets, and spheres is converted into nearly pure individual components.
A Semi-Open Loop GNSS Carrier Tracking Algorithm for Monitoring Strong Equatorial Scintillation (2017)

Strong equatorial ionospheric scintillation of radio signals is often associated with simultaneous deep amplitude fading and rapid random carrier phase fluctuations. It poses a challenge for satellite navigation receiver carrier phase tracking loop operation. This paper presents a semi-open loop algorithm that utilizes the known position of a stationary receiver and satellite orbit information to estimate carrier phase variations during deep signal fading. Strong GPS scintillation data collected on Ascension Island in March 2013 are processed to reveal fast phase changes of half and full cycles over tens of milliseconds on all three GPS frequencies. Simulated signals are used to validate the algorithm and confirm that the fast phase changes are true scintillation effects rather than receiver processing artifacts. The algorithm performance is demonstrated through comparison with several closed-loop implementations. Potential errors associated with receiver clock bias and other environmental factors are also analyzed. A statistical summary of the concurrent fast phase changes and deep fades based on the processing results of the Ascension Island data is presented.
Codebook design for millimeter-wave channel estimation with hybrid precoding structure (2016)

In this paper, we study hierarchical codebook design for channel estimation in millimeter-wave (mmWave) communications with a hybrid precoding structure. We propose an approach to design a hierarchical codebook exploiting BeaM Widening with Multi-RF-chain Sub-array technique (BMW-MS). To obtain crucial parameters of BMW-MS, we provide a closed-form (CF) solution to pursue a flat beam pattern. Performance comparisons show that BMW-MS/CF outperforms the existing alternatives under the per-antenna power constraint, which is adopted due to the limited saturation power of mmWave power amplifier.
Epsilon geometry: building robust algorithms from imprecise computations (1989)

This thesis introduces Epsilon Geometry, a framework for the development of robust geometric algorithms using inaccurate primitives. Epsilon Geometry is based on a very general model of imprecise computations, which includes floating-point and rounded-integer arithmetic as special cases. The algorithms in this framework produce exact solutions for perturbed versions of their input and return a bound on the size of these implicit perturbations.
The thesis begins with a formal description of the Epsilon Geometry framework. It introduces the notions of an epsilon predicate, a geometric predicate that can be satisfied by a perturbed version of its arguments; and a critical distance, the size of the perturbation required to make an epsilon predicate true. It also introduces epsilon and delta boxes, the implementations of these mathematical concepts as computer programs. The thesis describes some general rules for turning mathematical lemmas about epsilon predicates and critical distances into implementations of epsilon and delta boxes. Next, it presents a basic set of two-dimensional geometric predicates that are used for all of the algorithms in the sequel.
The second half of the thesis examines how Epsilon Geometry can be applied to various geometric objects and algorithms in the plane. It defines the notions of an $\varepsilon$-convex polygon, a polygon that can be made convex by perturbing each of its vertices by $\varepsilon$ or less; and a ($-\varepsilon)$-convex polygon, a polygon that remains convex even if its vertices are all displaced in arbitrary directions by a distance of $\varepsilon$ or less. The thesis develops robust algorithms for testing point inclusion in both kinds of polygons, and for testing a polygon's degree of convexity. Finally, the thesis investigates the existence of approximate hulls for sets of points. It proves that for every point set there exists a ($-\varepsilon$)-convex polygon H such that every point of the set is at most 4$\varepsilon$ away from H, and it describes robust algorithms for computing such hulls.
A Stroke-Based RNN for Writer-Independent Online Signature Verification (2019)

In the field of online handwritten signature verification, it is challenging to verify handwritten signature in a writer-independent scenario. In recent years, many researchers have been applying deep neural network methods to the signature verification task. However, these methods have not outperformed traditional methods, especially when the training samples are limited. In this paper, we propose a novel stroke-based bidirectional RNN architecture. The main idea is to split the signature into multiple patches using strokes. Concatenation of query and reference signature pairs are used as input. The proposed method uses two LSTM RNN networks to extract different features. The first one extracts the features of the strokes and the latter extracts the global features of the whole signatures. The results on the BiosecureID dataset demonstrate that our proposed method can reduce the EER by 33.05%, from 5.6% to 3.75% with fewer features and less training samples. Besides, we find that the proposed stroke based RNN network is 5x faster in training and testing time than Non stroke-based RNN network.
LDAP-Based Unified User Identity Management Technology in Digital Campuses (2005)

This paper studies LDAP and the related technologies, and puts forward a unified identity management solution and describes the key technologies related to this model. The solution realizes unified authentication, single-sign-on, unified authorization and unified management to the resources of network application.
Arylboronic Acids and Arylpinacolboronate Esters in Suzuki Coupling Reactions Involving Indoles. Partner Role Swapping and Heterocycle Protection. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Transcriptional control of chondrocyte fate and differentiation (2005)

Chondrogenesis is an essential process in vertebrates. It leads to the formation of cartilage growth plates, which drive body growth and have primary roles in endochondral ossification. It also leads to the formation of permanent cartilaginous tissues that provide major structural support in the articular joints and respiratory and auditory tracts throughout life. Defects in chondrogenesis cause chondrodysostoses and chondrodysplasias. These skeletal malformation diseases account for a significant proportion of birth defects in humans and can dramatically affect a person's expectancy and quality of life. Chondrogenesis occurs when pluripotent mesenchymal cells commit to the chondrocyte lineage, and through a series of differentiation steps build and eventually remodel cartilage. This review summarizes and discusses our current knowledge and lack of knowledge about the chondrocyte differentiation pathway, from mesenchymal cells to growth plate and articular chondrocytes, with a main focus on how it is controlled by tissue patterning and cell differentiation transcription factors, such as, but not limited to, Pax1 and Pax9, Nkx3.1 and Nkx3.2, Sox9, Sox5 and Sox6, Runx2 and Runx3, and c-Maf.
Improved maintenance support by multi-version visualizations (2003)

The author proposes a set of visualizing techniques exploiting versioning information easily accessible in a software repository. The novel contribution is the active use of version information. The author uses the term multiversion visualizations, since a visual representation containing information aggregated from several versions of the software is computed. The proposed techniques are applicable both in a programming-in-the-large perspective and in the detailed coding phases. It is argued that these methods can be used to improve the support for maintenance of large, evolving program systems. A prototype currently being implemented featuring some of these techniques is briefly mentioned.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>