gebhart/patrepeval huggingface dataset:
Citywide Traffic Flow Prediction Based on Multiple Gated Spatio-temporal Convolutional Neural Networks (2020)

Traffic flow prediction is crucial for public safety and traffic management, and remains a big challenge because of many complicated factors, e.g., multiple spatio-temporal dependencies, holidays, and weather. Some work leveraged 2D convolutional neural networks (CNNs) and long short-term memory networks (LSTMs) to explore spatial relations and temporal relations, respectively, which outperformed the classical approaches. However, it is hard for these work to model spatio-temporal relations jointly. To tackle this, some studies utilized LSTMs to connect high-level layers of CNNs, but left the spatio-temporal correlations not fully exploited in low-level layers. In this work, we propose novel spatio-temporal CNNs to extract spatio-temporal features simultaneously from low-level to high-level layers, and propose a novel gated scheme to control the spatio-temporal features that should be propagated through the hierarchy of layers. Based on these, we propose an end-to-end framework, multiple gated spatio-temporal CNNs (MGSTC), for citywide traffic flow prediction. MGSTC can explore multiple spatio-temporal dependencies through multiple gated spatio-temporal CNN branches, and combine the spatio-temporal features with external factors dynamically. Extensive experiments on two real traffic datasets demonstrates that MGSTC outperforms other state-of-the-art baselines.
Q-modules: internally clocked delay-insensitive modules (1988)

Q-modules are internally clocked modules that can be used to satisfy delay-insensitive specifications. A single delay element is required with a one-sided bound that its value be greater than the maximum delay of the combination logic. Prototypes of components to implement Q-modules have been designed, and a design aid program, QSYN, to place instances of these components, personalize a PLA, and generate a MAGIC or CIF file for a CMOS realization, including the delay circuitry, is being developed. Testability is one of the advantages of Q-modules over clock-free delay-insensitive modules; circuitry is included in the cells for testing the logic and interconnections.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A general heuristic or production planning problems (2001)

We consider production planning problems with the restriction that all integer variables model setups. Since finding a feasible solution of such problems is in general NP-complete, the classical approaches have been the use of heuristics to find good feasible solutions on the one hand, or Branch&Cut on the other hand. In the case of the former, a dual bound is not available, and there is no guarantee of solution quality. For the latter, the accent has been on improving the dual bound and only the simplest schemes have been used to find good feasible solutions. Here we first show that such simple schemes may run into trouble, even when applied to very simple problems. This motivates the proposed heuristic, IPE, which is designed to be used within a Branch&Cut approach. We test the performance of the heuristic on various published lotsizing and network design problems, with and without tightened reformulations. We compare these results with other heuristics and with time truncated B&B searches. IPE appears to be the best choice for large problems with weak formulations.
A biotin‐dependent sodium pump: glutaconyl‐CoA decarboxylase from <i>Acidaminococcus fermentans</i> (1982)

The decarboxylation of glutaconyl-CoA to crotonyl-CoA in the anaerobic bacterium Acidaminococcus fermentans is catalysed by a membrane-bound, biotin-dependent enzyme which requires Na+ for activity. Inverted vesicles from A. fermentans accumulated Na+ only if glutaconyl-CoA was decarboxylated. The Na+ uptake was inhibited by avidin but not by the avidin biotin complex. Detergents and ionophores such as monensin also prevented the Na+ transport. The results indicate that the enzyme is able to convert the free energy of decarboxylation (delta Go' approximately equal to -30 kJ/mol) into a Na+ gradient.
Machine learning techniques for web intrusion detection — A comparison (2016)

The rapid development of web applications has created many security problems related to intrusions not just on computer, network systems, but also on web applications themselves. In Web Intrusion Systems (WIS), most techniques used nowadays are not able to deal with the dynamic and complex nature of cyber-attacks on web applications and related issues. However, web intrusion techniques based on machine learning approaches with statistical analysis of data enable autonomous detect intrusive and non-intrusive traffic with low false-positive errors. In this paper, we present the survey of various machine learning techniques used to build WIS. In addition, we develop the experimental framework for comparative analysis of some machine learning techniques applying on the well-known benchmark data set - CSIC 2010 HTTP [13].
Photoenhanced Degradation of Methylene Blue on Cosputtered M:TiO<sub>2</sub> (M = Au, Ag, Cu) Nanocomposite Systems: A Comparative Study (2010)

Titania thin film system containing noble metallic nanoparticles such as Au, Ag, and Cu have been prepared by utilizing radio frequency reactive magnetron cosputtering method. The structural and morphological properties of the thin films were characterized by X-ray diffraction (XRD) and atomic force microscopy (AFM). Surface chemical composition of the films was determined by X-ray photoelectron spectroscopy (XPS). Optical properties of the TiO2 annealed films containing Au, Ag, and Cu metallic nanoparticles were investigated by UV−visible spectrophotometry showing surface plasmon resonance of the metals. The photocatalytic activity of all synthesized samples annealed at 600 °C in an Ar + H2(80 + 20%) environment was evaluated by measuring the rate of photodegradation reaction of methylene blue (MB) under similar conditions in the presence of UV and visible light irradiation. The Au:TiO2 and Cu:TiO2 thin film systems significantly enhanced photodecomposition of MB resulting in 80 and 90% of its initial concentration after 200 min photoirradiation, respectively. The increase in the surface roughness measured by AFM observation and the presence of the Ti3+ oxygen vacancy in the photoirradiated thin films were found responsible for the enhancement of the MB photodegradation reaction. The photoenhancement of the studied was determined in the following order: Cu:TiO2 > Au:TiO2 > Ag:TiO2 > TiO2.
Mutiple-view object tracking using metadata (2007)

In this paper we present a moving object tracking method in a multiple camera tracking system using meta-data. The proposed method acquires image sequences from multiple fixed cameras without a priori camera calibration. The tracking is performed based on object’s robust characteristics, such as motion, shape, color, and etc. Elements of meta-data and the optimal tracking method are selected at each frame. Because object’s characteristics are affected by camera position and environmental condition, tracking method between individual cameras is selected by optimal metadata.Tracking in a single view can be divided into three classes, such as; optical flow-based moving object detector, active shape model (ASM), color correlation based detector. The proposed method matches objects to most similar object color information, by comparing meta-data and ASM. In the experiment, the proposed multi-camera tracking system is show to be robust for non-rigid objects.
A 10 µs Hybrid Optical-Circuit/Electrical-Packet Network for Datacenters (2013)

We built and evaluated a hybrid electrical-packet/optical-circuit network for datacenters using a 10 µs optical circuit switch using wavelength-selective switches based on binary MEMs. This network has the potential to support large-scale, dynamic datacenter workloads.
Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimers Disease (2008)

The therapeutic arsenal for the treatment of Alzheimer's disease (AD) remains confined to a group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to provide a relief of the very late symptoms of the dementia, i.e. the cognitive and functional decline. In line with the growing body of evidence of the pivotal role of the beta-amyloid peptide (Abeta) in the pathogenesis of AD, alternative classes of drugs targeting mainly the formation or the aggregation of Abeta are actively pursued by the pharmaceutical industry, as they could positively modify the course of AD, stopping or slowing down disease progression. While the first amyloid-directed disease-modifying drugs go ahead with their clinical development and could reach the market as soon as 2009, mounting preclinical and clinical evidences is pointing towards a disease-modifying role also for currently marketed anti-Alzheimer AChE inhibitors (AChEIs), particularly for donepezil. In this review, the neuroprotective effects exhibited by currently commercialized AChEIs will be briefly discussed, together with the secondary mechanisms through which they could exert such effects. This review will focus also on particular classes of AChEIs, namely dual binding site AChEIs, which are being purposely designed to target Abeta aggregation and / or other biological targets that contribute to AD pathogenesis, thus constituting very promising disease-modifying anti-Alzheimer drug candidates.
Bcl10 mediates LPS-induced activation of NF-κB and IL-8 in human intestinal epithelial cells (2007)

Lipopolysaccharide (LPS) is recognized as an inducer of the inflammatory response associated with gram-negative sepsis and systemic inflammatory response syndrome. LPS induction proceeds through Toll-like receptor (TLR) in immune cells and intestinal epithelial cells (IEC). This report presents the first identification of Bcl10 (B-cell CLL/lymphoma 10) as a mediator of the LPS-induced activation of IL-8 in human IEC. Bcl10 is a caspase-recruitment domain-containing protein, associated with constitutive activation of NF-kappaB in MALT (mucosa-associated lymphoid tissue) lymphomas. The normal human IEC line NCM460, normal primary human colonocytes, and ex vivo human colonic tissue were exposed to 10 ng/ml of LPS for 2-6 h. Effects on Bcl10, phospho-IkappaBalpha, NF-kappaB, and IL-8 were determined by Western blot, ELISA, immunohistochemistry, and confocal microscopy. Effects of Bcl10 silencing by small-interfering RNA (siRNA), TLR4 blocking antibody, TLR4 silencing by siRNA, and an IL-1 receptor-associated kinase (IRAK)-1/4 inhibitor on LPS-induced activation were examined. Following Bcl10 silencing, LPS-induced increases in NF-kappaB, IkappaBalpha, and IL-8 were significantly reduced (P < 0.001). Increasing concentrations of LPS were associated with higher concentrations of Bcl10 protein when quantified by ELISA, and the association between LPS exposure and increased Bcl10 was also demonstrated by Western blot, immunohistochemistry, and confocal microscopy. Exposure to TLR4 antibody, TLR4 siRNA, or an IRAK-1/4 inhibitor eliminated the LPS-induced increases in Bcl10, NF-kappaB, and IL-8. Identification of Bcl10 as a mediator of LPS-induced activation of NF-kappaB and IL-8 in normal human IEC provides new insight into mechanisms of epithelial inflammation and new opportunities for therapeutic intervention.
Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). (1987)

Murine B cell growth factor II (BCGF-II/interleukin 5) was purified from the conditioned media of the helper T cell line D10 . G4 . 1. The purification scheme consisted of sequential batch adsorption onto trimethylsilyl-controlled pore glass beads, high pressure ion exchange chromatography, and reverse phase high pressure liquid chromatography. The purified BCGF-II had a relative molecular weight of 45,000 when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under nonreducing conditions. Identical analysis of BCGF-II under reducing conditions yielded a m.w. of 22,500, suggesting that native BCGF-II exists as a homodimer. The NH2-terminal amino acid sequence of the purified lymphokine was determined by automated Edman degradation. A single amino acid sequence of 24 residues was obtained that, upon comparison, was contained within the cDNA pSP6K-mTRF23 recently described as encoding murine BCGF-II/T cell-replacing factor. The NH2-terminal methionine in mature BCGF-II is found at position 21 of the amino acid sequence predicted from the cDNA pSP6K-mTRF23. This finding supports the contention of Kinashi et al. (Kinashi, T., N. Harada, E. Severinson, T. Tanabe, P. Sideras, M. Konishi, C. Azuma, A. Tominaga, S. Bergstedt-Lindqvist, M. Takahashi, F. Matsuda, Y. Yaoita, K. Takatsu, and T. Honjo. 1986. Nature 324:70) that amino acids 1-20 serve as the signal sequence for the BCGF-II gene. The ability of BCGF-II to stimulate the proliferation of the B cell lymphoma BCL1 was used to assess the potency of the lymphokine. BCGF-II at 13.5 pM induced 50% of the maximal proliferative response in the BCL1 cells; concentrations as low as 2 pM were still effective in stimulating the growth of the cells. Assuming that the amount of BCGF-II necessary to mount a 50% response in the BCL1 assay is defined as one unit of activity, then the purified BCGF-II has a specific activity of 16.5 U/ng of protein.
Parkinson's Disease Motor Symptoms in Machine Learning: A Review (2013)

This paper reviews related work and state-of-the-art publications for recognizing motor symptoms of Parkinson's Disease (PD). It presents research efforts that were undertaken to inform on how well traditional machine learning algorithms can handle this task. In particular, four PD related motor symptoms are highlighted (i.e. tremor, bradykinesia, freezing of gait and dyskinesia) and their details summarized. Thus the primary objective of this research is to provide a literary foundation for development and improvement of algorithms for detecting PD related motor symptoms.
Phosphorus-31 nuclear magnetic resonance spectroscopy in the determination of conformational free energies of phosphorus groups on the cyclohexane ring (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorus-31 nuclear magnetic resonance spectroscopy in the determination of conformational free energies of phosphorus groups on the cyclohexane ringMichael D. Gordon and Louis D. QuinCite this: J. Am. Chem. Soc. 1976, 98, 1, 15–23Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/ja00417a004https://doi.org/10.1021/ja00417a004research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Software Radios: Unifying the Reconfiguration Process over Heterogeneous Platforms (2005)

Future radio transceivers supporting the software radio concept will provide increased features for radio access networks. However, the reconfiguration of radio equipment requires the existence of an architecture, a common framework, which allows the flexible management of software running on radio processors. Such a framework must take into account the heterogeneity of hardware devices and platforms for radio applications. Since the flexibility has a cost in terms of added overhead, a conceptually simple but efficient structure that allows powerful mechanisms to develop and deploy software radio applications is required. This paper describes our approach, the reasons that motivated it, and some implementation issues. The proposed framework is essentially based on four items: an abstraction layer which hides any platform-dependent issue, a simple time-driven software structure, a delimited interface format for software blocks which does not actually constrain communication, and a global time-reference mechanism to guarantee real-time behaviour.
A 4-ns 4K*1-bit two-port BiCMOS SRAM (1988)

The authors introduce a two-port BiCMOS static random-access memory (SRAM) cell that combines ECL-level word-line voltage swings and emitter-follower bit-line coupling with a static CMOS latch for data storage. With this cell, referred to as a CMOS storage emitter access cell, it is possible to achieve access times comparable to those of high-speed bipolar SRAMs while preserving the high density and low power of CMOS memory arrays. The memory can be read and written simultaneously and is therefore well-suited to applications such as high-speed caches and video memories. A read access time of 3.8 ns at a power dissipation of 520 mW has been achieved in an experimental 4K*1-bit two-port memory integrated in a 1.5- mu m 5-GHz BiCMOS technology. The access time in this prototype design is nearly temperature-insensitive, increasing to only 4 ns at a case temperature of 100 degrees C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Composition, Physicochemical and Sensorial Properties of Commercial Plant-Based Yogurts (2020)

The aim of this study was to determine the key physicochemical, sensory and quality attributes of plant-based yogurts made from soy, coconut, cashew, almond and hemp, including a dairy benchmark yogurt. The soy, coconut and cashew-based yogurts showed textural parameters comparable to the dairy yogurt, with firmness values of 0.46, 0.44, 0.51 and 0.36 N, respectively. Rheological analysis showed that one of the soy-based yogurts was similar to the dairy yogurt in terms of apparent viscosity, in addition to water-holding capacity (82.8% and 75.7%, respectively). Other plant-based yogurts, e.g., hemp, showed different rheological and textural parameters to the other plant-based products, relating this to the agar and rice starch components of the hemp formulation. The sensory analysis demonstrated that some plant-based yogurts were similarly appreciated to dairy-based products. This was due mainly to the presence of specific hydrocolloids, sweeteners and flavours in the formulations; for example, the acceptability of the soy- and dairy-based yogurts were identical (5.95). The results obtained in this study allowed identification of key quality attributes of plant-based yogurt products and highlighted relationships between such attributes and formulation, which can be exploited in future product development.
Cooperative Dimerization of Fibroblast Growth Factor 1 (FGF1) upon a Single Heparin Saccharide May Drive the Formation of 2:2:1 FGF1·FGFR2c·Heparin Ternary Complexes (2005)

The related glycosaminoglycans heparin and heparan sulfate are essential for the activity of the fibroblast growth factor (FGF) family as they form an integral part of the signaling complex at the cell surface. Using size-exclusion chromatography we have studied the capacities of a variety of heparin oligosaccharides to bind FGF1 and FGFR2c both separately and together in ternary complexes. In the absence of heparin, FGF1 had no detectable affinity for FGFR2c. However, 2:2:1 complexes formed spontaneously in solution between FGF1, FGFR2c, and heparin octasaccharide (dp8). The dp8 sample was the shortest chain length that bound FGFR2c, that dimerized FGF1, and that promoted a strong mitogenic response to FGF1 through FGFR2c. Heparin hexasaccharide and various selectively desulfated heparin dp12s failed to bind FGFR2c and could only interact with FGF1 monomerically. These saccharides formed 1:1:1 complexes with FGF1 and FGFR2c, which had no tendency to self-associate, suggesting that binding of two FGF1 molecules to the same saccharide chain is a prerequisite for subsequent FGFR2c dimerization. We found that FGF1 dimerization upon heparin was favored over monomeric interactions even when a large excess of saccharide was present. A cooperative mechanism of FGF1 dimerization could explain how 2:2:1 signaling complexes form at the cell surface, an environment rich in heparan sulfate.
Deep Density Clustering of Unconstrained Faces (2018)

In this paper, we consider the problem of grouping a collection of unconstrained face images in which the number of subjects is not known. We propose an unsupervised clustering algorithm called Deep Density Clustering (DDC) which is based on measuring density affinities between local neighborhoods in the feature space. By learning the minimal covering sphere for each neighborhood, information about the underlying structure is encapsulated. The encapsulation is also capable of locating high-density region of the neighborhood, which aids in measuring the neighborhood similarity. We theoretically show that the encapsulation asymptotically converges to a Parzen window density estimator. Our experiments show that DDC is a superior candidate for clustering unconstrained faces when the number of subjects is unknown. Unlike conventional linkage and density-based methods that are sensitive to the selection operating points, DDC attains more consistent and improved performance. Furthermore, the density-aware property reduces the difficulty in finding appropriate operating points.
Dipyridamole potentiates antipurine antifolate activity in the presence of hypoxanthine in tumor cells but not in normal tissues in vitro. (1998)

The cytotoxicity of the antifolate inhibitors of de novo purine biosynthesis, lometrexol (LTX) and LY309887, can be abolished by hypoxanthine (HPX) salvage. The nucleoside transport inhibitor, dipyridamole (DP) can prevent HPX rescue from LTX growth inhibition in a cell line-specific manner. The studies described here have shown that, excluding colon and hematological malignancies, DP prevents HPX rescue from LTX growth inhibition in approximately one-third of cell lines with otherwise limited tissue specificity. The clinical dose-limiting toxicities of antipurine antifolates are to the bone marrow and gastrointestinal tract. In vitro models of these normal tissues were established, and the effect of DP on HPX rescue from LY309887 treatment was studied. Growth inhibition assays are not feasible in these primary cultures; therefore, an alternative assay, cellular ATP depletion, was validated in four tumor cell lines as a marker of de novo and salvage purine synthesis. In LY309887-treated cells, DP prevented HPX-mediated maintenance of ATP levels only in cell lines in which DP inhibited HPX rescue from antifolate cytotoxicity. Hence, ATP depletion is a reliable indicator of sensitivity of HPX transport to DP when direct cell growth measurement is impractical. In primary cultures of human hematopoetic progenitor cells and mouse small intestine, coincubation with HPX prevented LY309887-mediated ATP depletion, which was not blocked by DP. These data suggest that DP would not prevent HPX rescue from antipurine antifolate growth inhibition in sensitive normal tissues, whereas activity against certain solid human tumors would be maintained.