gebhart/patrepeval huggingface dataset:
Prediction of ovulation by urinary hormone measurements with the home use ClearPlan® Fertility Monitor: comparison with transvaginal ultrasound scans and serum hormone measurements (2000)

The timing of sexual intercourse in relation to ovulation strongly influences the chance of conception. Daily serum LH measurements or transvaginal ultrasonography are not practical to determine ovulation in consecutive cycles for an individual. A prospective study was initiated to test the home use performance of the ClearPlan Fertility Monitor (CPFM) in ovulation prediction compared with transvaginal ultrasonography and serum hormone measurements. A total of 53 women aged 18-39 years with a normal uterus and at least one ovary, cycle length between 21-42 days and not using medication which interferes with ovarian function contributed 150 cycles for analysis. One cycle was anovulatory and no LH surge, indicating peak fertility, was detected by the monitor. Of the remaining 149 cycles, 135 (90.6%) had a monitor LH surge and ultrasonographically confirmed ovulation. Ovulation was detected in 91.1% of cycles during the 2 days of CPFM peak fertility. Ovulation was observed in 51.1% of cycles 1 day and in 43.2% of cycles 2 days after the surge in serum LH. Ovulation never occurred before CPFM peak fertility or the serum LH surge day. CPFM can help women who desire pregnancy to time intercourse. It may also have potential as a diagnostic aid and for monitoring the treatment of infertility.
Hydrogeology and Hydraulic Field Test in Musashino Diluvial Terrace, Japan (1994)

On the basis of the 600 boring data points, contour maps of the upper and lower boundary of gravel aquifers were obtained in Musashino Diluvial Terrace, Japan. Lower boundary map shows a deep valley and a spreading ridge. In the area where the slope of the upper boundary counter map is less than 1 to 100, a clay layer overlays over the gravel layer. This clay layer seems affected by main stream of old Tama river. To grasp the actual groundwater runoff process, hydraulic field tests were carried out in 40 wells. Hydraulic conductivities derived from field pumping tests widely varied and averaged value over the valley area is about 10- 2cm/s, but that over the ridge area is less than 10{-2}cm/s. Direction of ground water measured by velocimeter is vertical to counter map of upper boundary of gravel layer.
Chemical mechanisms for cytochrome P-450 hydroxylation: evidence for acylation of heme-bound dioxygen. (1980)

Using isotopic tracer methods, we have shown that dihydrolipoic acid (2,3-thioctic acid) acylates the distal oxygen of ferrous oxygenated Pseudomonas cytochrome P-450, forming a transient acyl peroxide intermediate that facilitates oxygen-oxygen bond cleavage. Single-turnover studies with 18O2 indicate one oxygen-18 atom incorporated into the carboxylate group of lipoic acid for each oxygen-18 inserted into the substrate, camphor, forming the product, exo-5-hydroxycamphor. Such a branching ratio for label indicates that water is initially released from an unlageled position and illustrates that the general P-450 mixed-function oxidase stoichiometry generates H218O from 18O2 only after multiple-turnover equilibration with the acylating carboxylate oxygen. Formation of an acyl peroxide state is a natural intermediate in peracid, "oxene", or radical mechanisms for methylene carbone oxygenation.
연구논문 : 초임계 CO2를 이용한 상전화법에 의해 제조된 미세 다공질 폴리카보네이트막의 특성 (2003)

초임계 CO₂를 이용한 상전화법에 의해 제조된 미세 다공질 폴리카보네이트 막의 특성을 이해하기 위해 실험을 실시했다. 다공질 막의 공극률은 30 wt% 폴리에틸렌글리콜이 초기에 사용된 조건에서 메탄올, 에탄올, n-부탄올과 같은 유기용매를 사용하여 측정한 결과 약 72~77%였다. 막에 남아있는 폴리에틸렌글리콜은 초기 10 min 동안 약 95% 감소되었으며 그 후에는 시간이 지남에 따라 완만한 속도로 제거되었다. 일정시간, 일정온도 조건하에서 폴리카보네이트 막 내부에서의 폴리에틸렌글리콜의 제거율은 150 bar까지는 압력이 올라감에 따라 증가했지만 그 이상의 압력에서는 압력이 증가하면 오히려 제거율이 감소했다.
Specific Binding of Nuclear Proteins to a Bifunctional Promoter Element Upstream of the H1/AC Box of the Testis-Specific Histone H1t Gene1 (2003)

The testis-specific histone H1t gene is transcribed exclusively in primary spermatocytes during spermatogenesis. Studies with transgenic mice show that 141 base pairs (bp) of the H1t proximal promoter accompanied with 800 bp of downstream sequence are sufficient for tissue-specific transcription. Nuclear proteins from testis and pachytene spermatocytes produce footprints spanning the region covering the repressor element (RE) from 100 to 125 nucleotides upstream of the H1t transcriptional initiation site. Only testis nuclear proteins bind to the 5'-end of the element and produce a unique, low-mobility complex in electrophoretic mobility shift assays. This testis complex is distinct from the complex formed by a repressor protein derived from several cell lines that binds to the 3'-end of the element. The testis complex band is formed when using nuclear proteins from primary spermatocytes, where the H1t gene is transcribed, and band intensity drops 70%-80% when using nuclear proteins from early spermatids, where H1t gene transcription ceases. Protein-DNA cross-linking experiments using testis nuclear proteins produce electrophoretic bands of 59, 52, and 50 kDa on SDS/PAGE gels.
A Resonant Switched-Capacitor IC and Embedded System for Sub-Module Photovoltaic Power Management (2012)

The viability of grid-connected photovoltaic (PV) energy has improved dramatically in recent years: large increases in manufacturing capacity have driven reductions in cost and higher efficiencies, improving lifetime cost of energy (LCOE). Mismatch loss remains an important consideration in PV systems and a range of power electronic solutions have been proposed to recover losses due to shading, dust/debris, factory mismatch and aging. This paper presents a high-voltage CMOS IC and embedded system based on a resonant switched-capacitor converter. The solution is integrated into the junction box to balance power flow in parallel with sub-module strings of PV cells. A custom dual-core cable and connector extend the balancing function to multiple PV modules connected in series, improving energy production of large-scale PV arrays in the case of shading or mismatch. The converter is based on a resonant switched-capacitor (ReSC) topology that achieves effective conversion efficiency over 99% for a wide range of mismatch, insertion loss below 0.1%, a vertical footprint less than 6 mm, and weight less than 1 Oz.
Survival of patients with radiation enteritis of the small and the large intestine. (1995)

We reviewed the clinical and survival data of 108 consecutive patients who presented with radiation enteritis between 1965 and 1981. One hundred and two (94%) had been irradiated for carcinoma of the cervix uteri. The median follow-up was of 11 years. The median time of occurrence of severe radiation-induced lesions (obstruction, perforation) after radiotherapy was of 18 months, against 10.5 months for mild symptoms (e.g., tenesmus) and 9 months for rectal bleeding (p < 0.001). Cox survival analysis taking into account the stage of the cancer and the age at diagnosis showed that rectal bleeding is a factor with a prognosis significantly poorer than the mild symptoms (p = 0.05), equivalent to that of the severe complications. We conclude that in the evaluation of patients who underwent radiotherapy for abdominal or pelvic tumours, rectal bleeding should be considered as a sign of serious radiation-induced complication.
Building Information Management (BIM) and Blockchain (BC) for Sustainable Building Design Information Management Framework (2019)

At present, sustainable design is experiencing energy consumption and cost-effectiveness challenges in the building industry. A recent body of literature argues that the development of emerging smart digital technologies, such as Building Information Management (BIM) and blockchain (BC), offer immediate benefits to the industry. However, the current application of BIM and BC in the sustainable design and construction process focuses on smart energy and construction management, with little attention to addressing challenges for applying BIM to sustainable design and proposing strategies in terms of the usability of these technologies in the management of building construction projects. Therefore, this paper sets out to explore the potential roles of an integrated BIM and BC approach for sustainable building design information management. The first attempt is presented to use BC aided BIM for sustainable building design coordination and collaboration in multiple building stages. BC has the potential to address challenges that hinder the industry from using BIM for sustainable design, which has been unearthed. An innovative BC enhanced transaction process in BIM is required for sustainable building development. Roles of a user level driven smart contract system of BC can be used to enhance BIM system in the sustainable buildings process. The role of BC is primarily at user level driven smart contracts and their record value exchange capabilities. A user level (BIM stakeholders) driven BC technology for transaction in BIM process flow is revealed, and the user level (sustainable building design project stakeholders/BIM clients) driven and the smart contract enabled BIM+ BC architecture to address challenges of BIM for sustainable design has been further circulated according to the literature. Subsequently, a conceptual architecture of BIM + BC for Sustainable Building Design Information Management Framework in building project management has been proposed, validated, and refined. The Framework has two level encompassing structures and flow. The high-level framework is focused on strategy, whilst the low-level framework demonstrates technical components in detail. This architecture supporting project stakeholders in managing information, has the potential to achieve and ensure the realization of sustainable design goals through the interactive realization of smart contracts integrated into the user level driven BIM + BC system and its recording value exchange function through three user-driven levels, namely user, system, and transaction.
The Spread of Antibiotic-Resistant Bacteria through Medical Tourism and Transmission Prevention Under the International Health Regulations (2011)

Medical tourism-travel by healthcare patients to a foreign location for medical treatment-is a growing industry. Healthcare is nationally regulated in eveU county, and difficulties arise where legal remedies and standards vary between a medical tourist's resident and destination county. Antibiotic-resistant bacteria, which are typically limited to healthcare settings and close community quarters, have predictable risk factors. These predictable risk factors generally reduce concern regarding healthcare-associated strains in the medical community because hospitals can set admission and contact policies to reduce the spread of healthcare-associated strains. As medical tourism increases, however, the spread of healthcare-associated antibiotic-resistant bacteria infections is also likely to increase because patients are more likely to be exposed to hospitals and healthcare settings in different countries. Patients may thus spread their infections to facilities around the world. One recently discovered antibiotic-resistant strain of bacteria has shown evidence of fast international spread due to connections with medical tourism. There are a number of possible solutions to the public health and economic implications of the rapid spread of existing and potential antibiotic-resistant bacteria. These solutions include: containment strategies implemented by the World Health OrganiZation (WIIHO) under the International Health Regulations 2005 (1HR); race-to-the-top strategies that do not require state intervention at any level, where patients seek out hospitals that best manage infectious disease; containment procedures utiliZed by individual countries to prevent incoming infections, similar to the classical IHR regime; and information-forcing regimes at either national or international levels, which can supplement any of the other three regulatory and economic solutions by instituting reporting requirements on individual states. To date, the WIHO has never used the IHR to make recommendations regarding antibiotic-resistant bacteria. This Comment discusses the growth and practices of medical tourism, the development and spread of antibiotic-resistant bacteria, and compares the attributes of antibiotic-resistant bacteria to the attributes of previously declared pandemic diseases. This Comment proposes that the application of the IHR to antibiotic-resistant bacteria spread though medical tourism is consistent with the language of the IHR and concludes that the IHR offers the most efficient and potentially effective method of combating transmission of antibiotic-resistant bacteria.
Hepatitis B virus (1984)

Conference Article| August 01 1984 Hepatitis B virus K. MURRAY K. MURRAY 1Department of Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1984 Biochemical Society1984 Biochem Soc Trans (1984) 12 (4): 705. https://doi.org/10.1042/bst0120705 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation K. MURRAY; Hepatitis B virus. Biochem Soc Trans 1 August 1984; 12 (4): 705. doi: https://doi.org/10.1042/bst0120705 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
Problem of glucose and lipid metabolism in dialyzed diabetic patients (1985)

糖尿病 (DM) 性腎症透析例の予後は, いまだ不良であり導入後1年以内の死亡例が多い. 私どもは, DM性腎症腎不全45症例で導入時の腎不全, 糖・脂質代謝異常, 導入時臨床症状等の病態と予後を対比検討した. さらに同-9症例で, HF (hemofiltration), HD (hemodialysis) による糖・脂質代謝に対する改善効果を対比した.導入時検査所見では, 生存期間1年未満群 (10例) は, 1年以上群 (35例) に比し有意にBUN高値 (145±48mg/dl) 低クレアチニン値 (10.9±2.8mg/dl) を示した. 空腹時血糖値は1年未満群で251±219mg/dl, 1年以上群で133±70mg/dlで, 前者で高値をみた. 脂質ではTG (triglyceride) が1年未満群239±78mg/dl, 1年以上群163±73mg/dlと前者で有意に高値であった. DM病型, 年齢, Ht, 血圧には差はなし. 脳血管, 心血管障害等のmacroangiopathyの合併は1年未満群でそれぞれ50%, 80%で, 1年以上群の17.1%, 31.4%に比し前者で有意に高頻度でみられた. 導入時主要症状では1年未満群で心不全, 肺浮腫が多くみられた. 死因では血管死が1年未満群で70%で1年以上群の22.2%に比し高頻度にみられた. 糖代謝障害, macroangiopathy, 高TG血症が導入後予後を左右する.同-9症例で行ったHF, HDによる糖代謝の改善の対比ではOral-GTTでの30分値のinsulinogenic indexには差がみられなかった. ΣIRI/ΣBS値ではHFで42.0±21.5μU/mg, HDで29.8±23.4μU/mgでHFで有意に高値でありinsulin分泌の増加がみられた. HF濾液中にはinsulin拮抗物質のsomatostatinが高濃度に検出された. 脂質代謝ではHFではTG 158±48mg/dl, HDでは190±82mg/dlでHFで改善傾向をみた. T-lipid, P-lipid, lipoprotein分画, HDL-cholesterolには差はみられなかった.糖・脂質代謝の改善の面からはHFはDM腎症に適切な浄化方法と考えられる.
Looking Ahead: Tomorrow’s Innovations Built on Today’s Foundation (2014)

Creativity is not the finding of a thing, but the making of something out of it after it is found.
Secret Sharing for Health Data in Multi-provider Clouds (2013)

The accelerated adoption of cloud computing among enterprises is due to the multiple benefits the technology provides, one of them the simplification of inter-organizational information sharing, which is of utmost importance in healthcare. Nevertheless, moving sensitive health records to the cloud still implies severe security and privacy risks. With this background, we present a novel secure architecture for sharing electronic health records in a cloud environment. We first conducted a systematic literature review and interviews with different experts from the German healthcare industry that allowed us to derive real-world processes and corresponding security and privacy requirements. Based on these results, we designed our multi-provider cloud architecture that satisfies many of the requirements by providing increased availability, confidentiality and integrity of the medical records stored in the cloud. This architecture features secret sharing as an important measure to distribute health records as fragments to different cloud services, which can provide higher redundancy and additional security and privacy protection in the case of key compromise, broken encryption algorithms or their insecure implementation. Finally, we evaluate and select a secret-sharing algorithm for our multi-cloud architecture. We implemented both Shamir's secret-sharing scheme and Rabin's information dispersal algorithm and performed several experiments measuring the execution time. Our results indicate that an adoption of Rabin's algorithm would create a low overhead, giving strong indicators to the feasibility of our approach.
Ecosystem Services, the Millennium Ecosystem Assessment, and the Conceptual Difference between Benefits Provided by Ecosystems and Benefits Provided by People (2007)

While the idea of is crucial to environmental decision-making, usage of the term ecosystem services is haphazard at best. The Millennium Ecosystem Assessment, reflecting the consensus of the largest group of experts ever assembled in the area of change, encouraged increased coordination between international environmental agreement regimes and between these regimes and other international organizations. Increased coordination, however, cannot take place because of a lack of uniformity in the adoption of the Millennium Ecosystem Assessment's definition. Moreover, some States discourage the use of ecosystem services because its usage in the context of payment for systems has created the perception that people will have to pay for previously free benefits. To implement the Millennium Ecosystem Assessment's recommendations, decision-makers will have to draw a distinction between benefits provided by ecosystems and human protection of these ecosystems and use ecosystem services to refer to the former exclusively.
Plasma Acceleration in a Compact Helicon Source Using RF Antennae (2009)

-3 ) that enables electromagnetic acceleration. We newly employed an acceleration coil or 2 pairs of copper plates around the 2.5 cm o. d. glass tube. These methods are called a repetitious coil current acceleration and a continuous “Lissajous” acceleration, respectively. In case of the repetitious coil acceleration, the maximum plasma velocity of 3.6 km/s was obtained with a 76% velocity increment with the absorbed plasma production + acceleration power of (400+180) W and the applied magnetic field strength of 1,450 gauss. As for the “Lissajous” acceleration, the plasma velocity was 2.2 km/s with the absorbed plasma production + acceleration power of (290+200) W.
Length-Weight Relationship and Mortalities of Mullus barbatus ponticus Essipov, 1927 in the Central Black Sea, Turkey (2017)

A total of 1301 red mullet specimens were monthly collected from commercial gill/trammel net and bottom trawl fisheries, especially landings to Sinop fishing ports between September 2016 and February 2017. Total length and weight of red mullet specimens were ranged from 8.2 cm to 20.2 cm (average: 13.5 ±0.05 cm), and 5.6 g to 86.5 g (average: 28.2 ±0.36 g), respectively. The samples were grouped densely between 12 and 14 cm. The 34.4% of all samples in this study are under legal size. The LWR equation calculated was W = 0.008 × TL3.1076 (R2= 0.9591). Age groups of red mullets in the Central Black Sea were ranged from I to IV. Mean lengths according to age groups were 10.1, 14.02 ±0.22, 16.63 ±1.30 and 19.6 ±0.15, respectively. Also, von Bertalanffy Growth Parameters were L∞ = 19.21 ±1.55 cm, K = 0.68 ±0.27 year-1, t0 = -0.13 ±0.48. Mortalities (M, F and Z) and exploitation rate (E) of red mullet from the Black Sea were 0.335 year-1, 0.398 year-1, 0.733 year-1 and 0.54 year-1, respectively.
Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion (1993)

ABSTRACT The role of matrix metalloproteinase-9 (MMP-9, 92 kDa gelatinase/type IV collagenase) in invasion of mononuclear phagocytes was studied with U937 monoblastoid cells. 12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor TNF and interleukin-1α (IL-1α) stimulated the production of MMP-9 by TPA-treated cells. TNF also induced the production of MMP-9 by TPA-untreated U937 cells without morphological differentiation. Other agents including dimethyl sulfoxide (DMSO), all-trans-retinoic acid (all-trans-RA), platelet-derived growth factor and 3′ ;5′-cyclic monophosphate had no effects on MMP-9 production by TPA-treated or-untreated cells, but all-trans-RA and DMSO did have a morphological effect on the differentiation of the cells. These data suggest that MMP-9 production by U937 cells is regulated by a mechanism independent of the differentiation to macrophage-like cells. MMP-9 was purified to homogeneity as an inactive zymogen with Mr 92,000 (proMMP-9) from TPA-differentiated U937 cells treated with TNF. ProMMP-9 was activated by p-aminophenylmercuric acetate (APMA) generating an active species of Mr 67,000. Trypsin and cathepsin G also attained activation of the zymogen to its full activity obtained by APMA activation, but plasmin, leukocyte elastase, thrombin and plasma kallikrein had no ability to activate it. APMA-activated MMP-9 degraded type I gelatin readily and cleaved native collagen types III, IV and V. Invasion assays using reconstituted basement membrane coupled with a type IV collagenolysis assay showed good correlations between invasiveness, type IV collagenolysis and proMMP-9 production. Invasion was significantly inhibited by EDTA, 2-macroglobulin and tissue inhibitor of metalloproteinases-1, but not by inhibitors of cathepsin G and leukocyte elastase. These data suggest that MMP-9 plays an important role in the invasion of mononuclear phagocytes through basement membranes.
Experimental Evaluation of Turbidity Impact on the Fluence Rate Distribution in a UV Reactor Using a Microfluorescent Silica Detector (2017)

Turbidity is a common parameter used to assess particle concentration in water using visible light. However, the fact that particles play multiple roles (e.g., scattering, refraction, and reflection) in influencing the optical properties of aqueous suspensions complicates examinations of their effects on ultraviolet (UV) photoreactor performance. To address this issue, UV fluence rate (FR) distributions in a photoreactor containing various particle suspensions (SiO<sub>2</sub>, MgO, and TiO<sub>2</sub>) were measured using a microfluorescent silica detector (MFSD). Reflectance of solid particles, as well as transmittance and scattering properties of the suspensions were characterized at UV, visible, and infrared (IR) wavelengths. The results of these measurements indicated that the optical properties of all three particle types were similar at visible and IR wavelengths, but obvious differences were evident in the UV range. The FR results indicated that for turbidity associated with SiO<sub>2</sub> and MgO suspensions, the weighted average FR (WAFR) increased relative to deionized water. These increases were attributed to low particle photon absorption and strong scattering. In contrast, the WAFR values decreased with increasing turbidity for TiO<sub>2</sub> suspensions because of their high particle photon absorption and low scattering potential. The findings also indicate that measurements of scattering and transmittance at UV wavelengths can be used to quantify the effects of turbidity on UV FR distributions.