gebhart/patrepeval huggingface dataset:
Abstract IA06: Designing immunostimulatory antibodies for cancer treatment (2015)

Abstract Immunomodulatory mAb, led by the checkpoint blockers against CTLA-4 and PD-1/PD-L1, are changing the outlook for a number of difficult to manage cancers, such as melanoma and non-small cell lung cancer, and look set to become blockbuster drugs in the near future. While there is still some uncertainty concerning how these reagents work, it is generally agreed that they target exhausted effector T cells and Tregs within the tumour tissue. An alternative way to regulate anti-cancer T cells is using immunostimulatory mAb which trigger activatory T-cell co-receptors, often of the TNF receptor superfamily. Interestingly, most preclinical models show that immunostimulatory mAb are as good if not better than checkpoint blockers in terms of therapeutic potency. However, other than some limited success with anti-CD40 mAb in pancreatic cancer, immunostimulatory mAb have yet to display the level of clinical success seen with the checkpoint blockers. In this lecture we will discuss the mechanisms of action of these two groups of reagents and explore how differences in the rodent and human antibody effector functions might explain why immunostimulatory mAb have not performed as well in patients. We will show how the mouse inhibitory Fc gamma Receptor (FcγR), FcγRIIB, plays a critical role in hyper-crosslinking agonistic anti-TNFR mAb, yet in humans the equivalent receptor is less available to perform this function. We will also discuss how this knowledge is being used to engineer new immunostimulatory mAb which can exploit human FcγR effectively, or even mAb which can operate independently of FcγR with the opportunity of potent agonistic function regardless of bio-availability of FcγR. Citation Format: Martin J. Glennie, Aymen Al-Shamkhani, Stephen A. Beers, Ann L. White, Peter W. Johnson, Ruth R. French, Mark S. Cragg. Designing immunostimulatory antibodies for cancer treatment. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2015;3(10 Suppl):Abstract nr IA06.
Inverse Correlation between the Extent of N-Glycan Branching and Intercellular Adhesion in Epithelia (2007)

The majority of cell adhesion molecules are N-glycosylated, but the role of N-glycans in intercellular adhesion in epithelia remains ill-defined. Reducing N-glycan branching of cellular glycoproteins by swainsonine, the inhibitor of N-glycan processing, tightens and stabilizes cell-cell junctions as detected by a 3-fold decrease in the paracellular permeability and a 2-3-fold increase in the resistance of the adherens junction proteins to extraction by non-ionic detergent. In addition, exposure of cells to swainsonine inhibits motility of MDCK cells. Mutagenic removal of N-glycosylation sites from the Na,K-ATPase beta(1) subunit impairs cell-cell adhesion and decreases the effect of swainsonine on the paracellular permeability of the cell monolayer and also on detergent resistance of adherens junction proteins, indicating that the extent of N-glycan branching of this subunit is important for intercellular adhesion. The N-glycans of the Na,K-ATPase beta(1) subunit and E-cadherin are less complex in tight renal epithelia than in the leakier intestinal epithelium. The complexity of the N-glycans linked to these proteins gradually decreases upon the formation of a tight monolayer from dispersed MDCK cells. This correlates with a cell-cell adhesion-induced increase in expression of GnT-III (stops N-glycan branching) and a decrease in expression of GnTs IVC and V (promote N-glycan branching) as detected by real-time quantitative PCR. Consistent with these results, partial silencing of the gene encoding GnT-III increases branching of N-glycans linked to the Na,K-ATPase beta(1) subunit and other glycoproteins and results in a 2-fold increase in the paracellular permeability of MDCK cell monolayers. These results suggest epithelial cells can regulate tightness of cell junctions via remodeling of N-glycans, including those linked to the Na,K-ATPase beta(1)-subunit.
Agglutination of Trypsinized Sheep Erythrocytes by the Pili of <i>Corynebacterium renale</i> (1974)

Corynebacterium renale strains which possessed numerous pili agglutinated trypsinized sheep erythrocytes, whereas those possessing only a few pili did not show such activity. By electron microscopy, the pili of C. renale adhered to the ghost of trypsinized sheep erythrocytes. After the treatment of C. renale with the homologous anti-pili serum, neither the agglutination of trypsinized sheep erythrocytes nor the adherence to the ghost by the pili were found. The adhesive property of the pili of C. renale was thus demonstrated.
Preparation and Structural Analysis of Actinidain-processed Atelocollagen of Yellowfin Tuna (<i>Thunnus albacares</i>) (2004)

Pepsin-hydrolyzed collagen (atelocollagen) is a trimer, consisting of alpha 1 and alpha 2 monomers, and shows molecular species corresponding to a monomer, dimer (beta chain), and trimer (gamma chain) by SDS-polyacrylamide gel electrophoresis. Atelocollagen was purified from yellowfin tuna (Thunnus albacares) by salt precipitation and cation-exchange chromatography. Enzymatic hydrolysis of the atelocollagen by actinidain, a cysteine protease purified from kiwifruit, was analyzed by SDS-polyacrylamide gel electrophoresis. The triple helical structure unique to collagen was retained in the atelocollagen as judged by circular dichroism spectra. The actinidain-processed atelocollagen showed only monomeric alpha 1 and alpha 2 chains, with no beta and gamma chains, by SDS-polyacrylamide gel electrophoresis; nevertheless, it retained the typical triple helical structure. It is suggested that actinidain cleaved the atelocollagen molecule at specific sites on the inside of the inter-strand cross-linking peptides.
Catalyst (2014)

The web is a catalyst for drawing people together around shared goals, but many groups never reach critical mass. It can thus be risky to commit time or effort to a goal: participants show up only to discover that nobody else did, and organizers devote significant effort to causes that never get off the ground. Crowdfunding has lessened some of this risk by only calling in donations when an effort reaches a collective monetary goal. However, it leaves unsolved the harder problem of mobilizing effort, time and participation. We generalize the concept into activation thresholds, commitments that are conditioned on others' participation. With activation thresholds, supporters only need to show up for an event if enough other people commit as well. Catalyst is a platform that introduces activation thresholds for on-demand events. For more complex coordination needs, Catalyst also provides thresholds based on time or role (e.g., a bake sale requiring commitments for bakers, decorators, and sellers). In a multi-month field deployment, Catalyst helped users organize events including food bank volunteering, on-demand study groups, and mass participation events like a human chess game. Our results suggest that activation thresholds can indeed catalyze a large class of new collective efforts.
A distributed MAC design for data collision-free wireless USB home networks (2009)

USB has been used at an enormous number of USB devices as a universal interface. Advances in USB and wireless communication technologies have led USB-IF (USB Implementers Forum) to establishment of WUSB(Wireless USB) standard 1.0 that has wired USB's speed and compatibility in addition to wireless technology's convenience. The wireless USB provides convenience. However, due to mobility of WUSB devices in multi-hop environment, DRP (Distributed Reservation Protocol) reservation conflicts happen frequently among devices with three-hop distance. To solve this problem, we propose a new DRP reservation scheme using a new 2-hop range DRP Availability IE for three-hop mobility support in WUSB networks with ultrawideband (UWB) technology. It is shown by simulation results that throughputs of devices at frequent three-hop range DRP reservation conflicts are largely increased.
Employing Si solar cell technology to increase efficiency of ultra‐thin Cu(In,Ga)Se<sub>2</sub> solar cells (2014)

Reducing absorber layer thickness below 500 nm in regular Cu(In,Ga)Se<sub>2</sub> (CIGS) solar cells decreases cell efficiency considerably, as both short-circuit current and open-circuit voltage are reduced because of incomplete absorption and high Mo/CIGS rear interface recombination. In this work, an innovative rear cell design is developed to avoid both effects: a highly reflective rear surface passivation layer with nano-sized local point contact openings is employed to enhance rear internal reflection and decrease the rear surface recombination velocity significantly, as compared with a standard Mo/CIGS rear interface. The formation of nano-sphere shaped precipitates in chemical bath deposition of CdS is used to generate nano-sized point contact openings. Evaporation of MgF<sub>2</sub> coated with a thin atomic layer deposited Al<sub>2</sub>O<sub>3</sub> layer, or direct current magnetron sputtering of Al<sub>2</sub>O<sub>3</sub> are used as rear surface passivation layers. Rear internal reflection is enhanced substantially by the increased thickness of the passivation layer, and also the rear surface recombination velocity is reduced at the Al<sub>2</sub>O<sub>3</sub>/CIGS rear interface. (MgF<sub>2</sub>/)Al<sub>2</sub>O<sub>3</sub> rear surface passivated ultra-thin CIGS solar cells are fabricated, showing an increase in short circuit current and open circuit voltage compared to unpassivated reference cells with equivalent CIGS thickness. Accordingly, average solar cell efficiencies of 13.5% are realized for 385 nm thick CIGS absorber layers, compared with 9.1% efficiency for the corresponding unpassivated reference cells.
Three-Dimensional Dynamic Random Access Memories Using Through-Silicon-Vias (2016)

This paper describes orthogonal scaling of dynamic-random-access-memories (DRAMs) using through-silicon-vias (TSVs). We review 3D DRAMs including DDR3, wide I/O mobile DRAM (WIDE I/O), and more recently, the hybrid-memory cube (HMC) and high-bandwidth memory (HBM) targeted for high-performance computing systems. We then cover embedded 3D DRAM for high-performance cache memories, reviewing an early cache prototype employing face-to-face 3D stacking which confirmed negligible performance and retention degradation using 32 nm server and ASIC embedded DRAM macros. A second cache system prototype based on POWER7 was developed to confirm feasibility of stacking μP and high density cache memory, with > 2 GHz operation. For test and assembly, a micro-electro-mechanical-system (MEMS) probe-card with an integrated active silicon chip, realized a 50 μm pitch micro-probing at-speed-active-test for known-good-die (KGD) sorting. Finally, oxide wafer bonding with Cu TSV demonstrated wafer-scale 3D integration, with TSV diameters as small as 1 μm. The paper concludes with comments on the challenges for future 3D DRAMs.
Fundamentals of product family architecture (2000)

Recognizing the rationale of a product family architecture (PFA) with respect to design for mass customization (DFMC), this paper discusses the fundamental issues underlying a PFA, including product information modeling, structural implications of product families, functional variety versus technical variety, class‐member relationships inherent in variety, modularity and commonality, PFA design spaces, and PFA composition. The background research is reviewed in terms of product architecture and modularity, product platform and product families, and product modeling and design process models. To organize product varieties in DFMC, a PFA should be described from three different perspectives, namely the functional (as seen from customer, sales and marketing viewpoints), behavioral (as seen from the product technology or design engineer perspective) and structural (as seen from the fulfillment or manufacturing and logistic perspective). Meeting diverse customer requirements and achieving volume economy simultaneously can be best achieved by synchronizing these three perspectives. In fact, the mappings between PFA views manifest the cooperative effort among different business functions, whilst three PFA views facilitate the integration of different phases of product development.
A model of wave associative processing (1992)

A novel approach to the design of devices demonstrating the behavior of biological organisms that can be based on the associative memory mechanism is presented. A model of associative memory is proposed in which the dependent number of memory elements linearly increases with the number of medium elements, and every element of the medium is impressed with the activities of all the other elements. The authors focus more on the technical realization of parallel calculations on neural-like elements than on the modeling of actual neural activity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Induction tool resolution (1994)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1994Induction tool resolutionAuthors: Qiang ZhouD. BeardD. J. HillikerQiang ZhouWestern Atlas Inc., D. BeardWestern Atlas Inc., and D. J. HillikerWestern Atlas Inc.https://doi.org/10.1190/1.1931985 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1931985FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1994ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1994 Pages: 1679 publication data© 1994 Copyright © 1994 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Qiang Zhou, D. Beard, and D. J. Hilliker, (1994), "Induction tool resolution," SEG Technical Program Expanded Abstracts : 761-764. https://doi.org/10.1190/1.1931985 Plain-Language Summary PDF DownloadLoading ...
Profiling over Adaptive Ranges (2006)

Modern computer systems are called on to deal with billions of events every second, whether they are instructions executed, memory locations accessed, or packets forwarded. This presents a serious challenge to those who seek to quantify, analyze, or optimize such systems, because important trends and behaviors may easily be lost in a sea of data. We present range adaptive profiling (RAP) as a new and general purpose profiling method capable of hierarchically classifying streams of data efficiently in hardware. Through the use of RAP, events in an input stream are dynamically classified into increasingly precise categories based on the frequency with which they occur. The more important a class, or range of events, the more precisely it is quantified. Despite the dynamic nature of our technique, we build upon tight theoretic bounds covering both worst-case error as well as the required memory. In the limit, it is known that error and the memory bounds can be independent of the stream size, and grow only linearly with the level of precision desired. Significantly, we expose the critical constants in these algorithms and through careful engineering, algorithm re-design, and use of heuristics, we show how a high performance profile system can be implemented for range adaptive profiling. RAP can be used on various profiles such as PCs, load values, and memory addresses, and has a broad range of uses, from hot-region profiling to quantifying cache miss value locality. We propose two methods of implementation, one in software and the other with specialized hardware, and we show that with just 8k bytes of memory range profiles can be gathered with an average accuracy of 98%.
Try-on experience with augmented reality comforts your decision (2019)

Purpose The purpose of this paper is to understand how augmented reality (AR) try-on experiences facilitate consumers’ shopping decision. Focusing on the immersion and psychological ownership, the study investigated how the properties of AR experiences (environmental embedding (EE) and simulated physical control (SPC)) affect decision comfort. Design/methodology/approach This research theoretically and empirically analyzes how each property of AR experiences affects consequential psychological states and then further increases decision comfort by employing an existing AR try-on mobile application. A total of 99 valid responses were used for the partial least square structural equation modeling analysis. One’s prior AR try-on experience was predicted as a moderator and analyzed using SPSS-based PROCESS macro. Findings The results demonstrated that EE and SPC evoke immersion and the feeling of ownership of a virtual product, which increased decision comfort. The moderating effect of one’s prior AR try-on experience showed that the impact of EE and SPC on immersion was attenuated for those with prior experience. Further, immersion mediated the effect of EE but SPC on the feeling of ownership, which corroborated the direct effect of SPC on the feeling of ownership. Practical implications Firms must consider technological and user-experience features that can induce users to perceive high levels of AR characteristics such as EE and SPC. Practitioners should develop realistic content that can correctly place virtual products on users to enhance EE. Including more interactive features is encouraged to provide users with a feeling of control toward the virtual product that directly leads to ownership and positively affects decision making. Further, practitioners need to be cautious about consumers getting used to the new technology; retailers and marketers need to focus on creating new and innovative content to continually engage customers. Originality/value This study adopted EE and SPC to determine how each property of AR experience forms the consequential psychological states, particularly depending on one’s prior experience. Methodologically, the study provided external validity in conducting an experiment by adopting an existing AR mobile application available in the market and employing an objective measure of respondents (e.g. prior AR try-on experience).
A Direct Power Conversion Topology for Grid Integration of Hybrid AC/DC Energy Resources (2012)

This paper proposes a multiple-input versatile matrix converter (VMC) for integrating hybrid ac/dc energy resources and storages to the power grid. The VMC is developed from the traditional indirect matrix converter but operates in the reverse-boost mode rather than in the forward-buck mode. The reverse-boost mode is more relevant here since most renewable sources and energy storages have lower voltages than the grid. The eventual VMC developed uses an alternative nine-switch converter, rather than usual six-switch voltage-source converter, for providing six input terminals in total. One three-phase ac source and three dc sources, or other source combinations, can therefore be connected to the VMC. Powers from these sources are channeled to the three-phase utility grid through the VMC's current-source inverter. Their proper dispatches are guaranteed by the proposed control and modulation schemes, which also help maintain near-sinusoidal input and output current waveforms. Mathematical proofs, simulation, and experimental results have shown that the VMC can indeed operate as intended.
An Architecture for 2-D IDCT for Real Time Decoding of MPEG/JPEG Compliant Bitstreams (2006)

In this paper, architecture for hardware implementation of 2-dimensional inverse discrete cosine transform (2-D IDCT) is described. The architecture is based on a recursive algorithm, which implements the 2-D operation using a series of 1-D operations. Pipelining/interleaving technique is employed in our recursive computing scheme to overcome the clock rate limitation in recursive computation and to reduce the number of multipliers and clock cycles. More specifically, we are able to make the processing speed remain nearly invariant by using a higher clock rate, while the number of non-trivial multipliers is reduced by half. Furthermore, the cosine terms involved in the digital filter coefficients are pre-calculated and are implemented as fixed coefficient CSD multipliers. Although this reduces the flexibility in the architecture for supporting different block sizes, but this cost pays off due to the high gain in the computational efficiency of fixed coefficient CSD multipliers. Using architectural schemes like pipelining/interleaving, the computation of an 8/spl times/8 IDCT block is completed in just 209 clock cycles. This can be used with an external microcontroller for displaying JPEG images in cell phone displays, where stored images in JPEG format only need to be decoded for display.
Development of a One-Step Immunocapture Real-Time RT-PCR Assay for Detection of Tobacco Mosaic Virus in Soil (2012)

Tobacco mosaic virus (TMV) causes significant losses in many economically important crops. Contaminated soils may play roles as reservoirs and sources of transmission for TMV. In this study we report the development of an immunocapture real-time RT-PCR (IC-real-time RT-PCR) assay for direct detection of TMV in soils without RNA isolation. A series of TMV infected leaf sap dilutions of 1:101, 1:102, 1:103, 1:104, 1:105 and 1:106 (w/v, g/mL) were added to one gram of soil. The reactivity of DAS-ELISA and conventional RT-PCR was in the range of 1:102 and 1:103 dilution in TMV-infested soils, respectively. Meanwhile, the detection limit of IC-real-time RT-PCR sensitivity was up to 1:106 dilution. However, in plant sap infected by TMV, both IC-real-time RT-PCR and real-time RT-PCR were up to 1:106 dilution, DAS-ELISA could detect at least 1:103 dilution. IC-real-time RT-PCR method can use either plant sample extracts or cultivated soils, and show higher sensitivity than RT-PCR and DAS-ELISA for detection of TMV in soils. Therefore, the proposed IC-real-time RT-PCR assay provides an alternative for quick and very sensitive detection of TMV in soils, with the advantage of not requiring a concentration or RNA purification steps while still allowing detection of TMV for disease control.
Molecular dynamics simulations and statistical coupling analysis of GPI12 in <i>L. major</i> : functional co-evolution and conservedness reveals potential drug–target sites (2015)

GPI12 represents an important enzyme in the GPI biosynthetic pathway of several parasites like 'Leishmania'. GPI activity is generally regulated through either the hindrance in GPI complex assembly formation or the modulation of the lipophosphoglycan (LPG) flux to either reduce or enhance the pathogenicity in an organism. Of the various GPI molecules known, GPI12 is an important enzyme in the GPI biosynthetic pathway which can be exploited as a target due to the substrate specificity difference in parasites and humans. In the present study, the functional importance of the co-evolving residues of the GPI12 protein of Leishmania has been highlighted using the GPI proteins belonging to the GlcNAC-deacetylase family. Exploring the active site of the GPI12 protein and designing inhibitors against the functional residues provide ways and means to change the efficiency of deacetylation activity of the enzyme. The activity of de-N-acetylase is low in the absence of metal ions like zinc. Hence we designed eight small molecules in order to modulate the activity of GPI12. Compound 8 was found to be an appropriate choice to target the agonist (GPI12) active site thereby targeting the residues which were essential in the Zn binding and chelation activity. Inhibition of these sites offered a strong constraint to block the protein activity and in turn GPI biosynthesis.