gebhart/patrepeval huggingface dataset:
Relation Grid: A Social Relationship Network Model (2005)

In this paper, a social network model based on real social relationships, referred as relation grid, is proposed. Relation grid is isomorphic to the actual social network; hence it can represent the actual social network well. It is discussed that the proposed model is pure distributed, scalable, self-adaptive and self-organized. The application perspective of relation grid is encouraging. It not only provides a new way to acquire social relationships, but also can be used as an underlying background to construct online communities and organization.
The HoverMesh (2004)

In this paper we propose a novel attempt to develop a spatial tangible user interface (TUI) [1] based on a deformable structure, the so-called HoverMesh. It consists of a stiff cubical, whose upper wall is composed of a deformable mesh of particle filled inflatable cells. This mesh can be deformed by inflating and/or deflating the cubical while consolidating (evacuating) and/or releasing (inflating) the cells. The HoverMesh is both an input and output device and we see its major benefit in the wide interaction area. The haptic feedback modality is thus embedded as well. The first results in our early experiments sustain the concept of a mesh based on inflatable cells.
Photosensitivity in childhood. (1981)

Out of a total of 370 patients with photosensitivity disorders, the light sensitivity had started at an age of 15 years or earlier in 95 cases (26%). Seventy-eight of these suffered from polymorphous light eruptions (PMLE). In half of the PMLE cases the morphology of the light-induced rash was classified as prurigo-like, and in one-fourth as vesicopapular. Other registered photodermatoses with childhood onset were xeroderma pigmentosum, erythropoietic protoporphyria, systemic lupus erythematosus and pellagra. No childhood cases of photosensitivity from external chemicals or internal medication were encountered.
Design of miniaturized LTCC baluns (2006)

In this article, lumped-element loaded methods are examined for the purpose of achieving miniaturized low-temperature co-fired ceramic (LTCC) baluns. These methods have proven to be very efficient in reducing the size occupied by the baluns in these designs. Several miniaturized LTCC balun structures are analyzed using the even-odd mode analysis method and the design curves are plotted. Based on the design curves, two design examples in the LTCC environment are presented in order to demonstrate our analysis. The proposed analysis process is validated by the simulated and measured results. © 2006 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2006.
Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy (2017)

Under pathological conditions, joints and skin are often affected by an imbalance in the breakdown and production of hyaluronic acid (HA). The unique biochemical and biomechanical properties provided by HA must be restored for the long-term lubrication and cushioning effects. To overcome the inconvenience of repeated injections and the rapid degradation of exogenous HA treatments, HA is conjugated to a thermosensitive polymer, enabling the spontaneous formation of nanoparticles (HA Nano) at body temperature. Three HA Nano preparations are tested for their injectability, sensitivity to enzymatic degradation and cytocompatibility. One of them is delivered via subcutaneous and intra-articular injections to healthy mice and tested in a murine osteoarthritis (OA) model. It is found to be biocompatible, to offer a prolonged residence time at the injection site, have the ability to protect cartilage, to reduce pro-inflammatory cytokines and to preserve epiphysis thickness. In this study, HA Nano spontaneously forms nanoparticles at body temperature in vivo and is a promising candidate for the next generation of the sustainable/long-lasting treatment of OA and potentially also dermatological conditions.
Direct Interaction and Reciprocal Regulation between ASK1 and Calcineurin-NFAT Control Cardiomyocyte Death and Growth (2006)

The calcium-calmodulin-activated protein phosphatase calcineurin functions as a key mediator of diverse biologic processes, including differentiation, apoptosis, growth, and adaptive responses, in part through dephosphorylation and activation of nuclear factor of activated T-cell (NFAT) transcription factors. Apoptosis signal-regulating kinase 1 (ASK1) is an upstream component of the mitogen-activated protein kinases that serves as a pivotal regulator of cytokine-, oxidative-, and stress-induced cell death. Here, we performed a yeast two-hybrid screen with calcineurin B as bait, which identified ASK1 as a direct physical interacting partner. The C-terminal 218 amino acids of ASK1 were sufficient to mediate interaction with calcineurin B in yeast, as well as in mammalian cell lysates. Importantly, endogenous calcium binding B subunit (CnB) protein interacted with endogenous ASK1 protein in cardiomyocytes at baseline, suggesting that the interaction observed in yeast was of potential biologic relevance. Indeed, calcineurin directly dephosphorylated ASK1 at serine 967 using purified proteins or mammalian cell lysates. Dephosphorylation of ASK1 serine 967 by calcineurin promoted its disassociation from 14-3-3 proteins, resulting in ASK1 activation. Calcineurin and ASK1 cooperatively enhanced cardiomyocyte apoptosis, while expression of a dominant negative ASK1 blocked calcineurin-induced apoptosis. Mouse embryonic fibroblasts deficient in ask1 were also partially resistant to calcineurin- or ionomycin-induced apoptosis. Finally, ASK1 negatively regulated calcineurin-NFAT signaling indirectly through c-Jun NH2-terminal kinase (JNK)- and p38-mediated phosphorylation of NFAT, which blocked calcineurin- and agonist-dependent hypertrophic growth of cardiomyocytes. Thus, ASK1 and calcineurin-NFAT constitute a feedback regulatory circuit in which calcineurin positively regulates ASK1 through direct dephosphorylation, while ASK1 negatively regulates calcineurin-NFAT signaling through p38- and JNK-mediated NFAT phosphorylation.
Cable (cbl) type II pili of cystic fibrosis-associated Burkholderia (Pseudomonas) cepacia: nucleotide sequence of the cblA major subunit pilin gene and novel morphology of the assembled appendage fibers (1995)

Previous studies have shown that appendage pili of Burkholderia cepacia strains isolated from patients with cystic fibrosis (CF) at The Hospital for Sick Children, Toronto, Canada, mediate adherence to mucus glycoproteins and also enhance adherence to epithelial cells. The specific pilin-associated adhesin molecule is a 22-kDa protein. In the present study we purified the major subunit pilin (17 kDa) and immunolocalized it to peritrichously arranged pili. On the basis of their novel morphological appearance as giant intertwined fibers, we refer to them as cable (Cbl) pili. Using an oligonucleotide probe corresponding to regions of the N-terminal amino acid sequence of the pilin subunit, we detected the encoding cblA gene in a chromosomal DNA library. Sequencing revealed this structural gene to be 555 bp in length, encoding a leader sequence of 19 amino acids, a cleavage site between the alanine at position 19 and the valine at position 20, and a mature pilin sequence of 165 amino acids. The calculated molecular mass is 17.3 kDa. Hydrophobic plus apolar amino acids account for 60% of the total residues. The pilin exhibits some similarities in its amino acid sequence to colonization factor antigen I and CS1 fimbriae of Escherichia coli. With the cblA gene used as a probe, hybridization assays of 59 independent isolates, including those from several geographically separated CF centers, plus environmental and clinical (non-CF) strains, gave positive results with all of the 15 CF-associated B. cepacia isolates from Toronto, plus a single strain from one other CF center (Jackson, Mississippi). The cblA gene is the first pilin subunit gene of B. cepacia to be identified.
Comparative response of whitening strips to a low peroxide and potassium nitrate bleaching gel. (2002)

The predominantly female (85%) and non-smoking (91%) study population ranged from 20-47 years of age. Both treatments yielded a statistically significant (P < 0.001) whitening benefit with respect to reduction in yellowness (Ab*) and improvements in other color endpoints (deltaL*, deltaE*, and a new parameter, deltaW*) compared to baseline. The strip group experienced greater color improvement on average for all color parameters in the study. After 7 days treatment, the adjusted mean deltab* was -1.24 in the strip group and -0.65 in the tray group, with these groups differing significantly (P = 0.04). Tooth sensitivity was reported by 13% of subjects using the hydrogen peroxide strips, compared to 22% of subjects using the carbamiide peroxide potassium nitrate tray system. No subjects discontinued treatment early due to an adverse event.
Effect of FABP5 gene silencing on the proliferation, apoptosis and invasion of human gastric SGC-7901 cancer cells (2017)

The aim of the present study was to examine the effect of fatty acid binding protein-5 (<i>FABP-5</i>) gene on the proliferation, apoptosis and invasion of human gastric cancer SGC-7901 cells. The viability, apoptosis and cell invasion of SGC-7901 cells before and after FABP5 knockdown were taken as the study objects, design and synthesis of siRNA interference sequence were conducted according to FABP-5 mRNA coding sequences, and SGC-7901 cells were transiently transfected. The human gastric cancer SGC-7901 cells were divided into three groups: FABP-5 siRNA group, negative control group and blank control group. <i>FABP-5 gene</i> mRNA and protein expression levels were detected by RT-PCR and western blot analysis. The CCK-8 assay was used to detect <i>in vitro</i> cell proliferation, flow cytometry (FCM) was used to detect changes in cell cycle and apoptosis in each group, TUNEL staining was used to detect apoptosis in each group, and the cell invasion chamber assay was used to detect cell invasiveness in each group. Each test was repeated three times. The results of the RT-PCR and western blot analysis showed that, expression of FABP-5 mRNA and protein in the FABP-5 siRNA group was significantly decreased compared with the negative and blank control groups. The cell growth rate in the FABP-5 siRNA group was significantly retarded, cell cycle was arrested in G0/G1 phase, the number of cells in S phase was reduced, and compared with the negative and blank control groups, the apoptotic rate in the FABP-5 siRNA group was significantly increased (P<0.01), while proliferation and invasiveness were significantly decreased (P<0.05). In conclusion, specific <i>FABP-5 gene</i> silencing may reduce the invasiveness of gastric cancer cells, inhibit cell proliferation, and arrest cell cycle in G0/G1 phase, resulting in a significant increase in apoptosis.
Measurement of Plasma Prostaglandin E <sub>2</sub> Using Capillary Gas Chromatography Negative Ion Chemical Ionization Mass Spectrometry (1983)

A stable isotope dilution assay for the measurement of plasma prostaglandin E2 (PGE2) employing capillary column gas chromatography-negative ion chemical ionization mass spectrometry (GC-NICIMS) is described. PGE2 was extracted from plasma using C18 and silica SEP-PAKS. Further purification and separation was accomplished by thin layer chromatography. The prostaglandin was analyzed as its pentafluorobenzyl ester-methoxime-trimethyl-silyl ether, using fragment ions at m/e 524 (protium) and m/e 528 (deuterium) for quantitation. The mean plasma concentration of PGE2 determined in 8 healthy volunteers was 2.8 +/- 2.0 pg/ml.
A Dimmable Light-Emitting Diode (LED) Driver With Mag-Amp Postregulators for Multistring Applications (2010)

Current imbalance should be avoided when multiple LED strings are connected in parallel. In this paper, a dimmable LED driver with magnetic-amplifier postregulators for multistring applications is presented. Powered by a common master source, parallel LED strings are individually regulated by their corresponding adaptive slave sources for current balancing in this proposal. Without linear current regulators, the proposed driver offers relatively high efficiency. Its structure is simpler than multiconverter structures for red, blue, and green LED applications, and is particularly suitable for LEDs with wide parameter variations. The performance of the proposed driver is experimentally verified by a 16.5-W prototype with a load of three 5.5-W LED strings.
Imaging with Ion Beams and Laser Postionization (1994)

We investigate the use of a liquid metal ion gun (LMIG) combined with multiphoton resonance ionization of sputtered atoms and/or molecules to acquire mass-selected images with submicrometer spatial resolution. Images from several model systems are presented including those of an In grid, and of patterned surfaces of benzo[a]pyrene and tryptophan thin films. Since postionization for these systems yields ionization efficiencies that are considerably higher than those achieved with secondary ion mass spectrometry (SIMS), spatial resolution of 2600 A for molecular species could be achieved while static conditions were maintained. Cooling of the sample to < 210 K was shown to be essential for molecular systems since the number of thermally evaporating molecules overwhelms the number of sputtered molecules at room temperature. Other details necessary to incorporate laser postionization into a time-of-flight SIMS instrument using a pulsed LMIG source are also discussed.
Defining Privacy for Data Mining (2002)

Privacy preserving data mining -- getting valid data mining results without learning the underlying data values -- has been receiving attention in the research community and beyond. It is unclear what privacy preserving means. This paper provides a framework and metrics for discussing the meaning of privacy preserving data mining, as a foundation for further research in this field.
Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy (2017)

Bacterial populations exhibit a range of metabolic states influenced by their environment, intra- and interspecies interactions. The identification of bacterial metabolic states and transitions between them in their native environment promises to elucidate community behavior and stochastic processes, such as antibiotic resistance acquisition. In this work, we employ two-photon fluorescence lifetime imaging microscopy (FLIM) to create a metabolic fingerprint of individual bacteria and populations. FLIM of autofluorescent reduced nicotinamide adenine dinucleotide (phosphate), NAD(P)H, has been previously exploited for label-free metabolic imaging of mammalian cells. However, NAD(P)H FLIM has not been established as a metabolic proxy in bacteria. Applying the phasor approach, we create FLIM-phasor maps of Escherichia coli, Salmonella enterica serovar Typhimurium, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus epidermidis at the single cell and population levels. The bacterial phasor is sensitive to environmental conditions such as antibiotic exposure and growth phase, suggesting that observed shifts in the phasor are representative of metabolic changes within the cells. The FLIM-phasor approach represents a powerful, non-invasive imaging technique to study bacterial metabolism in situ and could provide unique insights into bacterial community behavior, pathology and antibiotic resistance with sub-cellular resolution.
Carbohydrate nutrition of Paul's Scarlet rose cell suspensions (1975)

Paul's Scarlet rose cells grow equally well on either glucose, fructose, sucrose, or trehalose as a source of carbohydrate. When fructose-containing medium is autoclaved, it becomes inhibitory to growth. The extent of this inhibition appears to be dependent on the physiological age of the cells. Thus as cells enter the stationary phase, they become progressively more sensitive to inhibition by autoclaved fructose, whereas stationary-phase cells transferred to new medium become less sensitive to autoclaved fructose during the first 24 h. The inhibitory compound or compounds produced when fructose-containing medium is autoclaved have not been identified, but they appear to result mainly from the interaction of fructose with magnesium sulfate.
Detecting content adaptive scaling of images for forensic applications (2010)

Content-aware resizing methods have recently been developed, among which, seam-carving has achieved the most widespread use. Seam-carving's versatility enables deliberate object removal and benign image resizing, in which perceptually important content is preserved. Both types of modifications compromise the utility and validity of the modified images as evidence in legal and journalistic applications. It is therefore desirable that image forensic techniques detect the presence of seam-carving. In this paper we address detection of seam-carving for forensic purposes. As in other forensic applications, we pose the problem of seam-carving detection as the problem of classifying a test image in either of two classes: a) seam-carved or b) non-seam-carved. We adopt a pattern recognition approach in which a set of features is extracted from the test image and then a Support Vector Machine based classifier, trained over a set of images, is utilized to estimate which of the two classes the test image lies in. Based on our study of the seam-carving algorithm, we propose a set of intuitively motivated features for the detection of seam-carving. Our methodology for detection of seam-carving is then evaluated over a test database of images. We demonstrate that the proposed method provides the capability for detecting seam-carving with high accuracy. For images which have been reduced 30% by benign seam-carving, our method provides a classification accuracy of 91%.
Practical 3D geographic routing for wireless sensor networks (2010)

Geographic routing is of interest for sensor networks because a point-to-point primitive is an important building block for data-centric applications. While there is a significant body of work on geographic routing algorithms for two-dimensional (2D) networks, geographic routing for practical three-dimensional (3D) sensor networks is relatively unexplored. We show that existing 2D geographic routing algorithms like CLDP/GPSR and GDSTR perform poorly in practical 3D sensor network deployments and describe GDSTR-3D, a new 3D geographic routing algorithm that uses 2-hop neighbor information in greedy forwarding and 2D convex hulls to aggregate node location information. We compare GDSTR-3D to existing algorithms, including CLDP/GPSR, GDSTR, AODV, VRR and S4, both in a real wireless sensor testbed and with TOSSIM simulations to show that GDSTR-3D is highly scalable, requires only a modest amount of storage and achieves routing stretch close to 1.
Developmental and Hormonal Regulation of Rice [alpha]-Amylase(RAmy1A)-gusA Fusion Genes in Transgenic Rice Seeds (1995)

Transgenic seeds of rice (Oryza sativa L.) were used to investigate temporal, spatial, and hormonal regulation of a rice [alpha]-amylase gene, RAmy1A. Two overlapping segments of the RAmy1A promoter were fused to the coding region of the bacterial reporter gene, gusA. The resulting promoter-gusA fusions, pE4/GUS (-232 to +31) and pH4/GUS (-748 to +31), were used separately to transform rice protoplasts. [beta]-Glucuronidase (GUS) activity was detected in germinated transgenic seeds, although the two constructs showed no significant difference in timing or location of GUS expression. Both constructs first expressed GUS in the scutellar epithelium and then in the aleurone layer. Aleurone expression of GUS activity was strongly induced when embryoless half-seeds were treated with gibberellic acid. GUS expression in the aleurone layer was also suppressed by abscisic acid. These results indicate that the 5[prime] regulatory region from -232 to +31 is sufficient for temporal, spatial, and hormonal regulation of RAmy1A gene expression.
In vivo validation of free-space fluorescence tomography using nuclear imaging (2010)

The performance of small animal photonic imaging has been considerably improved since the development of fluorescence diffuse optical tomography (fDOT), which can reconstruct fluorescent probe distribution inside tissue. However, the quantification capabilities of this new technology are still a topic of debate, especially in comparison to classical nuclear imaging techniques. Here, we present a method to in vivo calibrate the quantity and localization of a probe provided by free-space fDOT (where no plate is compressing the mouse) with positron emission tomography (PET) and x-ray computed tomography, respectively. This methodology allowed us to demonstrate a strong linear correlation (R(2)=0.95) between fDOT and PET for probe concentrations ranging from 3 nM to 1 μM in a deep-seated organ.
A Selenium Analogue of Firefly <scp>D</scp> ‐Luciferin with Red‐Shifted Bioluminescence Emission (2012)

A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects.
Software change management (1996)

Software projects change rapidly, which makes efficient change management a major challenge for the software industry. This challenge was poorly met for years because of rudimentary tools. The paper considers how modern change management, or configuration control tools must encompass changes affecting every kind of software deliverable and artifact.
Ghrelin receptor (GHS‐R1A) antagonism suppresses both operant alcohol self‐administration and high alcohol consumption in rats (2011)

The mechanisms involved in alcohol use disorders are complex. It has been shown that ghrelin is an important signal for the control of body weight homeostasis, preferably by interacting with hypothalamic circuits, as well as for drug reward by activating the mesolimbic dopamine system. The ghrelin receptor (GHS-R1A) has been shown to be required for alcohol-induced reward. Additionally, ghrelin increases and GHR-R1A antagonists reduce moderate alcohol consumption in mice, and a single nucleotide polymorphism in the GHS-R1A gene has been associated with high alcohol consumption in humans. However, the role of central ghrelin signaling in high alcohol consumption is not known. Therefore, the role of GHS-R1A in operant self-administration of alcohol in rats as well as for high alcohol consumption in Long-Evans rats and in alcohol preferring [Alko alcohol (AA)] rats was studied here. In the present study, the GHS-R1A antagonist, JMV2959, was found to reduce the operant self-administration of alcohol in rats and to decrease high alcohol intake in Long-Evans rats as well as in AA rats. These results suggest that the ghrelin receptor signaling system, specifically GHS-R1A, is required for operant self-administration of alcohol and for high alcohol intake in rats. Therefore, the GHS-R1A may be a therapeutic target for treatment of addictive behaviors, such as alcohol dependence.
Sonochemically synthesis of arylethynyl linked triarylamines catalyzed by CuI nanoparticles: A rapid and green procedure for Sonogashira coupling (2014)

A simple and green method was performed to the preparation of copper iodide nanoparticles by ultrasound approach. Consequently the synthesis of aryl ethynyl linked triarylamines was carried out through the Sonogashira coupling between iodo-substituted triarylamine and aryl acetylenes in the presence of CuI nanoparticles/Pd(PPh3)2Cl2 as an efficient catalytic system and triethylamine as the base under ultrasonic irradiation. Good to excellent yields of products and short reaction times are some of the important advantages of this solvent free protocol which were attained by both nano CuI and ultrasound conditions.