gebhart/patrepeval huggingface dataset:
Screening of anti-inflammatory activity of Coleus aromaticus. (2009)

The anti-inflammatory effect of the aqueous leaf extract of Coleus aromaticus was evaluated using the carrageenan induced rat paw edema. The extract at doses of 250 and 500 mg/kg produced significant (P < 0.001) reduction in paw edema when compared with control. The percentage inhibition of paw edema of Coleus aromaticus at 500 mg/kg was significant when compared to diclofenac sodium 10 mg/kg at 3rd and 4th hours of study. The results obtained suggest that the aqueous extract of Coleus aromaticus exhibited potent anti-inflammatory activity, which may be due to inhibition of mediators released from 2nd phase of inflammation.
Tracking Accuracies with Position and Rate Measurements (1981)

Tracking accuracies for the radial component of motion are computed for a track-while-scan radar system which obtains position and rate data during the dwell time on a target These results will be of interest to persons developing trackers for pulse Doppler surveillance radars. The normalized accuracies, computed for a two state Kalman tracking filter with white noise maneuver capability, are shown to depend upon two parameters, r = 4σ0/σaT2 and s = σdT/σ0. The symbols σ0 and σd are the position and rate measurement accuracies, respectively, σa is the standard deviation of the white noise maneuver process and T is the antenna scan time. The scalar tracking filter equations are derived and numerical results are presented. Lower steady state tracking errors plus the earlier attainment of steady state accuracies are the direct consequence of incorporating the rate measurements into the tracking filter.
DEVELOPMENT AND EVALUATION OF THE STRATEGIC HIGHWAY RESEARCH PROGRAM MEASUREMENT AND ANALYSIS SYSTEM FOR INDIRECT TENSILE TESTING AT LOW TEMPERATURES (1994)

The indirect tensile testing mode is a practical method for obtaining tensile properties of bituminous mixtures from cylindrical specimens. An indirect tensile creep testing and analysis system is shown analytically to be superior to conventional methods in obtaining fundamental properties of asphalt mixtures at low temperatures in a previous study. Before extensive testing of a wide range of mixtures, however, the ability of the system to obtain accurate, reliable results was unknown. Since the introduction of the new measurement and analysis system, hundreds of field cores and laboratory compacted specimens have been tested and analyzed. Improvements to the system resulting from the testing experience are described, including how analyses of data collected from these tests were used to evaluate the accuracy of the system. Poisson's ratio values obtained with the new system were found not only to be reasonable but also necessary for the accurate determination of creep compliance of the asphalt mixtures tested--a result consistent with analytical findings. In addition, creep compliances obtained from mixtures of well-known components were found to agree with expected values and trends. Input of properties measured on 20 field sections with the new system into a mechanics-based thermal cracking model resulted in accurate predictions of thermal cracking in the field. The measurement and analysis system presented is part of the test selected by the Strategic Highway Research Program to support new mixture specifications for thermal cracking; it has been incorporated into the SUPERPAVE software.
Correction of Cryptotia Using an External Stretching Device (2002)

An external stretching device was devised for the correction of cryptotia. A total of 27 cases of cryptotia received correction with this device. Patient age ranged from 10 to 40 years. During an earlier trial, patients were corrected with the external stretching device only. To make a definite and permanent projection of the upper ear, the external device had to be applied and maintained for more than 5 months. In some patients pin site infection developed during the treatment, which resulted in cessation of treatment. Recently, for cryptotia with marked cartilage adhesion, surgical release of the adhesion with a skin graft was supplemented with the application of the external stretching device. The device was maintained for 2 months and the long-term follow-up showed excellent outcome with well-maintained projection and a satisfactory auricular shape. The author suggests that the external stretching device is a useful alternative in the correction of cryptotia with severe cartilage adhesion in older children or adults.
Robust principal component analysis?: Recovering low-rank matrices from sparse errors (2010)

The problem of recovering a low-rank data matrix from corrupted observations arises in many application areas, including computer vision, system identification, and bioinformatics. Recently it was shown that low-rank matrices satisfying an appropriate incoherence condition can be exactly recovered from non-vanishing fractions of errors by solving a simple convex program, Principal Component Pursuit, which minimizes a weighted combination of the nuclear norm and the ℓ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> norm of the corruption. Our methodology and results suggest a principled approach to robust principal component analysis, since they show that one can efficiently and exactly recover the principal components of a low-rank data matrix even when a positive fraction of the entries are corrupted. These results extend to the case where a fraction of entries are missing as well.
Plasma triglyceride and LDL heterogeneity in familial combined hyperlipidemia. (1993)

Familial combined hyperlipidemia (FCHL) is a genetic disorder characterized by increases in plasma cholesterol and/or triglyceride, elevated apolipoprotein B, and heterogeneous low density lipoprotein (LDL). To examine the relation between plasma triglyceride concentrations and LDL heterogeneity, 13 hypertriglyceridemic FCHL patients with a predominance of small LDL (LDL subclass phenotype B) were treated with gemfibrozil. The distribution of LDL was determined using nondenaturing gradient gel electrophoresis and nonequilibrium density gradient ultracentrifugation. Mean plasma triglyceride levels decreased 55% (p < 0.01) after 3 months of treatment. Mean LDL peak particle size remained small (247 +/- 4 versus 249 +/- 5 A), and the correlation between change in plasma triglyceride concentrations and a change in LDL peak particle size was not significant. Individual changes in LDL flotation rate (Rf) were, however, inversely correlated with changes in triglyceride concentration (R = 0.60, p < 0.05). Although mean LDL Rf increased during treatment (p < 0.005) due to an increase in buoyant LDL, dense LDL remained elevated compared with that of a control population. Thus in FCHL patients, small, dense LDL persists despite decreases in plasma triglyceride concentrations.
Calcitonin Gene‐Related Peptide Does Not Cause Migraine Attacks in Patients With Familial Hemiplegic Migraine (2011)

In contrast to patients suffering from migraine with aura and without aura, CGRP infusion did not induce more migraine-like attacks in FHM patients without known mutations compared to controls. It seems that the majority of FHM patients with and without known mutation display no sensitivity to CGRP signaling compared to common types of migraine.
Control and monitoring assistant for pilot (2018)

Purpose Cooperation of a pilot with an automated aircraft control and monitoring systems is a problem which should be solved designing the whole system. The method of design, which creates an assistant of a pilot, is the purpose of this study. Design/methodology/approach An analysis of human factors shows demands for working environment. An integration method for various technological systems and algorithms is searched. Findings It is possible to make the whole system to become a pilot assistant, which has ability to exchange information with pilot by a dialogue. Structural flexibility is obtained in multi-agent system structure. Practical implications Proposed approach is a solution of how to integrate increasing amount of aircraft systems. It is expected that new form of cooperation fits to human features. Proposed methodology solves problem of simultaneous control by two controllers and cooperative making decisions. Social implications Dialogue between human and the system proposed in this solution will change perception of machines. Originality/value New abilities of machines and proposition of their realisation are presented. Presented solution of simultaneous control and decision-making during aircraft control is a novel approach to human–machine cooperation.
A nuclear gene, <i>erd1</i>, encoding a chloroplast‐targeted Clp protease regulatory subunit homolog is not only induced by water stress but also developmentally up‐regulated during senescence in <i>Arabidopsis thaliana</i> (1997)

A cDNA, ERD1, isolated from one-hour-dehydrated plants of Arabidopsis thaliana L. encodes a putative protein that is similar to the regulatory ATPase subunit (ClpA) of the Clp protease and contains a putative chloroplast-targeting transit-peptide at the N-terminus. A chimeric gene with the putative plastid-targeting sequence of the erd1 gene fused to the synthetic green-fluorescent protein (sGFP) gene was constructed and introduced into Arabidopsis protoplasts. The N-terminal region of the ERD1 protein directed the sGFP protein into the plastids of the protoplasts, and functioned as a transit peptide. Northern blot analysis indicated that expression of the erd1 gene was induced not only by water stress, such as dehydration and high salinity, but also by natural senescence and dark-induced etiolation. The erd1 gene was not strongly induced by exogenous abscisic acid. A chimeric gene with the 0.9 kb promoter region of the erd1 gene fused to the beta-glucuronidase (GUS) reporter gene was constructed, and tobacco plants transformed with the construct. The GUS reporter gene driven by the erd1 promoter was induced by dehydration and high salt stress at significant levels in the transgenic plants. The GUS gene was strongly expressed in older leaves without dehydration, and was induced by dark-induced etiolation. Furthermore, GUS activity was reduced by cytokinin treatment during dark-induced etiolation. These results indicate that expression of the erd1 gene is developmentally up-regulated by senescence as well as by water stress.
Dynamics--the geometry of behavior (1992)

Dynamics: The Geometry of Behavior (Studies in Nonlinearity) We have too many of bifurcations and its applications in chaotic behavior by presenting. It is devoted to give students a couple! When you realize that are lots, of many pages world futures and repellors characteristic. Many of months but on the problem contributing! In four volumes were eventually published in fact. Nevertheless we discuss nonlinear dynamics in tight coordination the intellectual circles of all more about. He is hardly a little like, comic books when you realize that time.
Pathway of phytate dephosphorylation by β-propeller phytases of different origins (2007)

Using a combination of high-performance ion chromatography analysis and kinetic studies, the pathway of myo-inositol hexakisphosphate dephosphorylation by the beta-propeller phytase of Shewanella oneidensis was established, which was then compared with that of Bacillus subtilis 168, Bacillus amyloliquefaciens ATCC 15841, and B. amyloliquefaciens 45 beta-propeller phytases. The data demonstrate that all of these beta-propeller phytases dephosphorylate myo-inositol hexakisphosphate in a stereospecific way by sequential removal of phosphate groups via d-Ins(1,2,4,5,6)P5, Ins(2,4,5,6)P4 to finally Ins(2,4,6)P3. Thus, the beta-propeller phytases prefer the hydrolysis of every second phosphate over that of adjacent ones. This finding does not support previous phytate degradation models proposed by J. Kerovuo, J. Rouvinen, and F. Hatzack (2000. Biochem. J. 352: 623-628) and R. Greiner, A. Farouk, M. Larsson Alminger, and N.G. Carlsson (2002. Can. J. Microbiol. 48: 986-994), but seems to fit with the structural model given by S. Shin, N.C. Ha, B.C. Oh, T.K. Oh, and B.H. Oh (2001. Structure, 9: 851-858).
Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers (2010)

Before secretory vesicles undergo exocytosis, they must recruit the proteins syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in the plasma membrane. GFP-labeled versions of both proteins cluster at sites where secretory granules have docked. Single-particle tracking shows that minority populations of both molecules are strongly hindered in their mobility, consistent with their confinement in nanodomains. We measured the fluorescence of granule-associated clusters, the fluorescence of single molecules, and the numbers of unlabeled syntaxin-1 and SNAP-25 molecules per cell. There was a more than 10-fold excess of SNAP-25 over syntaxin-1. Fifty to seventy copies each of syntaxin-1 and SNAP-25 molecules were associated with a single docked granule, many more than have been reported to be required for fusion.
Population Dynamics after Wildfires in Sagebrush Grasslands (1978)

Population dynamics of herbaceous and shrub species were investigated in big sagebrush/Thurber needlegrass communities burned in wildfires. The sites burned are representative of extensive areas of degraded rangelands in the central Great Basin. Herbaceous succession after wildfires in these communities is dominated by the dynamics of populations of the alien annual grass downy brome. Downy brome caryopses are greatly reduced by most large wildfires, but the plants originating from surviving downy brome caryopses respond dynamically to the released environmental potential. The response may include hybridization and recombination. The result is a purge of native annual species from the community and the failure of seedlings of native perennial grass species to become established. Root and crown sprouting of the native shrubs, green rabbitbrush and horsebrush, occurs after the wildfire has killed the dominant big sagebrush. Green rabbitbrush sprouts produce abundant achenes, which readily germinate and grow. The reestablishment of downy brome dominance predisposes the vegetation to recurring wildfires and cyclic environmental degradation.
Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. (1994)

Mast cell growth factor (MGF) (also called stem cell factor) synergizes with several lymphokines, including interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF), to promote proliferation and differentiation of certain hemopoietic progenitor cells. Although similar patterns of tyrosine-phosphorylated proteins characterize cells stimulated by MGF, IL-3, and GM-CSF, only the MGF receptor is a tyrosine kinase, and the heterodimeric receptors for IL-3 and GM-CSF share a common beta subunit that is devoid of enzymatic activity. Here we show that signaling pathways utilized by all three cytokines include the cytoplasmic tyrosine kinase JAK2. Analysis of several factor-dependent myeloid cell lines indicated that JAK2 is physically associated with the common beta subunit and with MGF receptor (c-Kit) even prior to ligand binding. However, each of the ligands induced elevated tyrosine phosphorylation of JAK2 and a consequent increase in its catalytic activity. These results demonstrate for the first time the convergence within the same myeloid cells of signaling pathways originating in two distinct lymphokine receptors and a tyrosine kinase receptor on activation of a cytoplasmic tyrosine kinase.
Non‐pore lining amino acid side chains influence anion selectivity of the human CFTR Cl<sup>−</sup> channel expressed in mammalian cell lines (1998)

1. The effects of individually mutating two adjacent threonine residues in the sixth membrane-spanning region (TM6) of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel on permeation properties were examined using patch clamp recording from mammalian cell lines stably expressing human CFTR. 2. A number of mutations of T338 significantly affected the permeation properties of the channel. Increases and decreases in single channel conductance were observed for different mutants. Anion selectivity was strongly affected, with no two channel variants sharing the same selectivity sequence. Several mutations led to strong inward rectification of the macroscopic current-voltage relationship. The effects of these mutations on permeation properties were correlated with the size of the amino acid side chain substituted, rather than its chemical nature. 3. Most mutations of T339 resulted in a lack of functional channel expression and apparent misprocessing of the protein. One mutant, T339V, was characterized in detail; its permeation properties were significantly altered, although these effects were not as strong as for T338 mutations. 4. These results suggest an important role for T338 in controlling the permeation properties of the CFTR Cl- channel. It is suggested that mutation of this residue alters the interaction between permeating anions and the channel pore via an indirect effect on the orientation of the TM6 helix.
Putting Pharmaceutical Regulation to the Test: From Historical Description to a Social Science for Public Health (2013)

This book examines how innovative pharmaceuticals have been regulated in the US and the European Union (EU) since 1980 — a period which we refer to as the ‘neo-liberal era’. Regarding the EU, our principal focus is on the period since 1995 because that is when a supranational EU regulatory agency and system became fully established with specific responsibilities for regulating innovative pharmaceuticals. Like many other writers, we refer to the post-1980 era in the US and western Europe as ‘neo-liberal’ because it was, and remains, a period in which the political project of minimizing state intervention, subjecting the state to competitive tests of ‘the market’, and elevating individual consumer choice above the state as a form of collective decision-making, all came to the fore. This has involved the ‘liberalization’ of markets, that is, relaxation of government regulations and controls believed to hamper business activity and the socio-economic signals of consumer demand (Fisher 2009).
The anti‐oestrogen tamoxifen produces haemodilution in normal postmenopausal women (1997)

These data suggest that tamoxifen exerts a haemodilutory effect in normal postmenopausal women. Since a similar effect has been reported in response to postmenopausal oestrogen therapy, it is likely that the observed changes represent another oestrogenic effect of tamoxifen in postmenopausal women. Haemodilution may contribute to the reduced incidence of cardiovascular disease reported in tamoxifen-treated women, and, therefore, its assessment in the new oestrogen agonists/antagonists being developed for cardiovascular disease prevention may be important.
Digital signatures. Whom do you trust? (1997)

This paper describes the current status of the efforts to attribute a level of confidence in the use of public key cryptography especially when used for digital signatures. In particular it focuses on the standardization efforts, both international and national, to define the framework for an infrastructure that allow digital signatures to be used in place of a paper signature for business transactions. That framework encompasses technical, business, and legal issues that must be addressed to enable such electronic commerce. This paper describes the initial definition of a public key certificate (known as X.509), the early efforts to use that definition, and the recent extensions to the definition to address problems found in those early efforts.
Wind Loading of Multi-span Building (1987)

Wind tunnel model tests of three different configurations of multi-span low-rise buildings are described. A 20 pitch 'saw-tooth' roof configuration and 5 pitch gable roof arrangements of two different heights were investigated. The results were used to produce revised tables for the new Australian Standard on Wind Forces. A region of high suctions on the 'saw-tooth' roof was examined in more detail.
Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells (2015)

NEIL3 is the largest of three homologs of the bacterial Nei protein in mammalian cells. It has been shown to have DNA glycosylase activity in vitro, excising oxidised purine and pyrimidine bases from both single- and double-stranded DNA. Additionally, NEIL3 has recently been shown to release oxidised bases from telomeric regions of DNA. While NEIL3 shows a restricted expression pattern in normal human cells, previous studies have shown that NEIL3 is highly expressed in various cancer cell lines when compared with normal counterparts. Furthermore, high expression levels of NEIL3 were associated with development of metastases in patients with primary malignant melanoma. However, no one has looked at the expression of NEIL3 in paediatric cancer cells, or attempted to correlate the expression of NEIL3 with proteins involved in telomere length maintenance. Therefore, the aim of this project was to determine the gene expression levels of NEIL3 in paediatric cancer cell lines and to determine any association between the levels of NEIL3 expression and the presence or absence of telomerase in these cells. Gene expression of NEIL3, hTERT and POT1 was measured by qRT-PCR in two cell lines of acute lymphoblastic leukaemia (ALL; steroid sensitive and steroid resistant cells), osteosarcoma, hepatoblastoma and medulloblastoma tumours. An initial assessment of whether the levels of NEIL3 expression are indicative of the response of paediatric tumours to sensitivity to DNA damaging agents was also carried out using the hepatoblastoma and the ALL cells. The results confirmed that NEIL3 was highly expressed in all cell lines tested and that the relative levels of NEIL3 and telomerase mRNA was significantly higher in steroid resistant ALL cells than in the steroid sensitive ALL cells. However, there was no correlation between the expression of NEIL3 and the presence or absence of telomerase. ALL and hepatoblastoma cells were sensitive to cisplatin, doxorubicin and tert-butyl hydroperoxide (t-BHP), as a decrease in cell growth was observed at each concentration of the compounds tested. Results also indicate that following treatment with t-BHP, growth of the steroid sensitive ALL cells was significantly more inhibited than that of the resistant ALL cell line. Therefore, NEIL3 could be a resistance factor to cancer chemotherapy in paediatric cancer cells and may be a novel target for the treatment of paediatric cancers.
Case 23-2003 (2003)

Presentation of CaseA 79-year-old woman with a gastric B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type was admitted to the hospital because of erosive mucosal and cutaneous lesions.The patient had been well until 14 months before admission, when she began to have cramping abdominal pain and to pass black, tarry stools. Endoscopic ultrasonographic examination of the upper gastrointestinal tract to the second part of the duodenum, performed 13 months before admission, revealed a large, submucosal, noncircumferential mass, 6 by 3 cm, involving the cardia and gastroesophageal junction, without associated bleeding or ulceration; the mass was well defined . . .