gebhart/patrepeval huggingface dataset:
Membrane ruffling, macropinocytosis and antigen presentation in the absence of gelsolin in murine dendritic cells (1999)

Previous studies have shown that mice lacking the actin-severing and capping protein gelsolin have defects in leukocyte and platelet function. Moreover, dermal fibroblasts from gelsolin knockout (Gsn(-)) mice showed substantially reduced motility, membrane ruffling and pinocytosis. We have generated dendritic cells (DC) from spleens of Gsn(-) mice to investigate the importance of gelsolin in antigen endocytosis and processing. We show here that Gsn(-) DC produce apparently normal membrane ruffles which can resolve to form large macropinosomes. Moreover, presentation of exogenous antigens on both MHC class II and class I molecules was equivalent in Gsn(-) and wild-type DC. Thus the major rearrangements of the actin cytoskeleton needed for DC antigen uptake and presentation can proceed in the absence of a major actin filament regulatory protein.
Direction hole-filling method for a 3D view generator (2015)

Depth image-based rendering (DIBR) technology is an approach to creating a virtual 3D image from one single 2D image. A desired view can be synthesised at the receiver side using depth images to make transmission and storage efficient. While this technique has many advantages, one of the key challenges is how to fill the holes caused by disocclusion regions and wrong depth values in the warped left/right images. A common means to alleviate the sizes and the number of holes is to smooth the depth image. But smoothing results in geometric distortions and degrades the depth image quality. This study proposes a hole-filling method based on the oriented texture direction. Parallax correction is first implemented to mitigate the wrong depth values. Texture directional information is then probed in the background pixels where holes take place after warping. Next, in the warped image, holes are filled according to their directions. Experimental results showed that this algorithm preserves the depth information and greatly reduces the amount of geometric distortion.
Message Disposition Notification (2004)

This memo defines a MIME content-type that may be used by a mail user agent (MUA) or electronic mail gateway to report the disposition of a message after it has been successfully delivered to a recipient. This content-type is intended to be machine-processable. Additional message headers are also defined to permit Message Disposition Notifications (MDNs) to be requested by the sender of a message. The purpose is to extend Internet Mail to support functionality often found in other messaging systems, such as X.400 and the proprietary "LAN-based" systems, and often referred to as "read receipts," "acknowledgements", or "receipt notifications." The intention is to do this while respecting privacy concerns, which have often been expressed when such functions have been discussed in the past.
Pigments, Inorganic, 6. Luster Pigments (2009)

Abstract The article contains sections titled: 1. Introduction 2. Nacreous and Interference Pigments 2.1. Optical Principles 2.2. Natural Pearl Essence 2.3. Basic Lead Carbonate 2.4. Bismuth Oxychloride 2.5. Metal Oxide ‐ Mica Pigments 2.6. New Developments 2.7. Uses 3. Metal Effect Pigments
An IQ-steering technique for amplitude and phase control of mm-wave signals (2015)

In this contribution we present a custom test-bench capable of delivering multi-path mm-wave signals with amplitude and phase control to an on-wafer environment. The setup employs direct IQ up-conversion in the 7.5GHz to 10GHz band, with high resolution DACs to modulate both amplitude and phases of n coherent LO signals. Signal amplification followed by frequency multiplication generates mm-wave signals in the 30 to 40GHz range. An amplitude pre-distortion technique, to level the IQ mixer output power versus phase angle, and a calibration technique are developed to achieve accurate amplitude and phase control between the signals at the wafer probe-tip level.
Synthesis and Characterization of Novel Mesogen‐Jacketed Liquid Crystalline Miktoarm Star Rod‐Coil Block Copolymer (2005)

Abstract Summary: A series of novel mesogen‐jacketed liquid crystal miktoarm star rod‐coil block copolymers were synthesized via atom transfer radical polymerization (ATRP). Their architectures {coil conformation of styrene segment and rigid rod conformation of {2,5‐bis[(4‐methoxyphenyl)oxycarbonyl]styrene} (MPCS) segment} were confirmed by GPC, 1 H NMR, and MALDI‐TOF studies. The liquid crystalline behaviors of the synthesized copolymers are evidenced from POM observation. The liquid crystalline phase depends on the molecular weights of the rigid rod arm of miktoarm star copolymers. Miktoarm star rod‐coil block copolymer. magnified image Miktoarm star rod‐coil block copolymer.
Stable nickel hydride complexes of tricyclohexylphosphine and triisopropylphosphine (1971)

M. L. H. Green, T. Saito and P. J. Tanfield, J. Chem. Soc. A, 1971, 152 DOI: 10.1039/J19710000152
Microcapsules for New Animal Drugs (1984)

Microencapsulation techniques have been developed and refined for many years. However, in recent years, great strides have been made in controlling the microcapsule size down to the nanometer range when necessary. Progress has also been made in controlling the ratio of wall/capsule and the distribution of microcapsule diameter size in the batching of the capsules.One area of application for microencapsulation is the convenience of dosing large groups of animals once with a sustained-release dosage form rather than with repeated administration since this involves greater effort at animal management.For example, targeted dosages can be achieved by a specialized drug delivery system. Since animal systems are varied and ruminant animals have a digestive system that is different from and more complex than that of other animals, oral administration of a drug substance to be retained through the rumen to the abomasum for subsequent dissolution and/or excretion may be affected by a microencapsulation process. Miller and Gordon of USDA achieved this for control of fecal breeding flies by systemic retention of a microencapsulated pesticide drug into the manure.Perhaps one of the most challenging areas is that of pharmaceuticals. There is now considerable interest in the area of microparticulate drug delivery systems. Examples of how desirable nutritional properties and taste preference are achieved and how these provide improved animal products will be discussed. Additional areas of interest and some possible future systems that have advantages over conventional systems will be discussed.A brief description of some general requirements by the Food and Drug Administration (FDA) for approval of these drug delivery systems will be presented.
Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis (2012)

Autoimmune synaptic encephalitides are recently described human brain diseases leading to psychiatric and neurological syndromes through inappropriate brain-autoantibody interactions. The most frequent synaptic autoimmune encephalitis is associated with autoantibodies against extracellular domains of the glutamatergic N-methyl-d-aspartate receptor, with patients developing psychotic and neurological symptoms in an autoantibody titre-dependent manner. Although N-methyl-d-aspartate receptors are the primary target of these antibodies, the cellular and molecular pathway(s) that rapidly lead to N-methyl-d-aspartate receptor dysfunction remain poorly understood. In this report, we used a unique combination of high-resolution nanoparticle and bulk live imaging approaches to demonstrate that anti-N-methyl-d-aspartate receptor autoantibodies from patients with encephalitis strongly alter, in a time-dependent manner, the surface content and trafficking of GluN2-NMDA receptor subtypes. Autoantibodies laterally displaced surface GluN2A-NMDA receptors out of synapses and completely blocked synaptic plasticity. This loss of extrasynaptic and synaptic N-methyl-d-aspartate receptor is prevented both in vitro and in vivo, by the activation of EPHB2 receptors. Indeed, the anti-N-methyl-d-aspartate receptor autoantibodies weaken the interaction between the extracellular domains of the N-methyl-d-aspartate and Ephrin-B2 receptors. Together, we demonstrate that the anti-N-methyl-d-aspartate receptor autoantibodies from patients with encephalitis alter the dynamic retention of synaptic N-methyl-d-aspartate receptor through extracellular domain-dependent mechanism(s), shedding new light on the pathology of the neurological and psychiatric disorders observed in these patients and opening possible new therapeutic strategies.
Tumor‐Homing Poly‐siRNA/Glycol Chitosan Self‐Cross‐Linked Nanoparticles for Systemic siRNA Delivery in Cancer Treatment (2012)

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.
Multiple point mutations in an endogenous retroviral gene confer high immunogenicity on a drug-treated murine tumor. (1995)

Exposure in vivo of murine L5178Y lymphoma cells to cytoreductive triazene derivatives leads to the generation of immunogenic variant lines expressing new transplantation Ags recognized by CTL. In one such clonal variant (clone D), at least one subset of T cell neoepitopes are provided by proteins previously shown by serology to be products of endogenous retroviral env sequences. We report here on characterization of PCR-amplified gp70 env genes in clone D. Relative to known gp70 sequences in parental cells and in current databases, one gp70 sequence presented four distinct nucleotide changes, two of which were apparently unique to clone D DNA and cDNA upon differential hybridization analysis. Transfection experiments with the entire gp70 gene or subgenic fragments encompassing a single putative mutation showed that products of the mutated env gene or fragments may confer immunogenicity in vivo and susceptibility in vitro to lysis by clone D-primed, H-2Kd- or H-2Ld-restricted CTL. By skin test assay of mice primed with either clone D or three mutated synthetic peptides, evidence was obtained that amino acid substitutions at the relevant positions of the gp70 protein may produce immunogenic T cell epitopes and that these epitopes are expressed in vivo by clone D. These data point to the role of mutated retroviral tumor peptides as rejection Ags in histocompatible hosts.
CHROMOSOMES AND SEX IN SCHISTOSOMATIUM DOUTHITTI (1957)

Journal Article CHROMOSOMES AND SEX IN SCHISTOSOMATIUM DOUTHITTI: Trematoda: Schistosomatidae Get access ROBERT B. SHORT ROBERT B. SHORT *Department of Biological Sciences, Florida State UniversityTallahassee Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 48, Issue 1, January 1957, Pages 3–6, https://doi.org/10.1093/oxfordjournals.jhered.a106674 Published: 01 January 1957
Facet Appearance on the Lateral Face of Sapphire Single-Crystal Fibers during LHPG Growth (2016)

Results of the study of the lateral surface of single-crystal (SC) sapphire fibers grown along crystallographic directions [ 0001 ] and [ 11 2 ¯ 0 ] by the LHPG method are presented. The appearance or absence of faceting of the lateral surface of the fibers depending on the growth direction is analyzed. The crystallographic orientation of the facets is investigated. The microstructure of the samples is investigated with the help of an optical microscope and a JSM-5910LV scanning electronic microscope (JEOL). The crystallographic orientations of the facets on the SC sapphire fiber surface are determined by electron backscatter diffraction (EBSD). The seed orientation is studied by means of XRD techniques.
Multiple-Input Multiple-Output OFDM With Index Modulation: Low-Complexity Detector Design (2017)

Multiple-input multiple-output orthogonal frequency division multiplexing with index modulation (MIMO-OFDM-IM), which provides a flexible trade-off between spectral efficiency and error performance, is recently proposed as a promising transmission technique for energy-efficient 5G wireless communications systems. However, due to the dependence of subcarrier symbols within each subblock and the strong interchannel interference, it is challenging to detect the transmitted data effectively while imposing low computational burden to the receiver. In this paper, we propose two types of low-complexity detectors based on the sequential Monte Carlo (SMC) theory for the detection of MIMO-OFDM-IM signals. The first detector draws samples independently at the subblock level, while the second detector draws samples at the subcarrier level with further reduced complexity. To meet the constraint of the subcarrier combinations within each subblock, the second detector is further coupled with a carefully designed legality examination method. Attributed to the effectiveness of legality examination and deterministic SMC sampling, both proposed detectors achieve near-optimal error performance for the MIMO-OFDM-IM system.
Conversion of penicillin to cephalosporin via a double sulfoxide rearrangement (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of penicillin to cephalosporin via a double sulfoxide rearrangementDouglas O. SpryCite this: J. Am. Chem. Soc. 1970, 92, 16, 5006–5008Publication Date (Print):August 1, 1970Publication History Published online1 May 2002Published inissue 1 August 1970https://pubs.acs.org/doi/10.1021/ja00719a054https://doi.org/10.1021/ja00719a054research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prostatic Carcinoma: Incidence and Location of Unsuspected Lymphatic Metastases (1976)

Prospective pathologic staging by pelvic lymphadenectomy in 60 patients with clinically localized carcinoma of the prostate disclosed a high incidence (35 per cent) of clinically silent and unsuspected lymph node metastases. When present, metastatic disease was frequently bilateral (57 per cent) and most commonly involved the obturator-hypogastric lymph nodes (87 per cent). Micrometastases alone were found in 5 patients and the potential significance of this finding on survival is discussed. Although the presence or absence of metastases could not be accurately predicted by histologic analysis of biopsy or prostatectomy specimens, the finding of undifferentiated tumor, marked anaplasia and penetration through the capsule correlated positively with nodal metastases. Pelvic lymphadenectomy is a safe and important diagnostic tool in the accurate staging of these patients. Its widespread use is advocated in patients with clinical stage B1, B2 and C tumors prior to definitive therapy. Based on the prospective data generated in this study lymphatic metastasis appears to be an early event in the spread of prostatic cancer.
Editorial: Quality in distance education: Four cases (1997)

(1997). Editorial: Quality in distance education: Four cases. American Journal of Distance Education: Vol. 11, No. 3, pp. 1-7.
Customer Service: Guaranteed? (1998)

As part of the Telstra privatisation package, the 'Customer Service Guarantee' was proposed to apply to all telephone companies and it was intended to ensure that customer service levels are maintained and enhanced as a more competitive telecommunications market. The basic idea of the scheme was to establish minimum standards for certain areas of performance by communications service providers and to impose penalties, where service providers failed to meet them.
Scatterometry measurement of sub-0.1 μm linewidth gratings (1998)

The effort discussed here addresses the use of shorter incident wavelengths for characterizing sub-0.1 μm linewidths and the corresponding influence on scatterometry measurement sensitivity to linewidth variations. A sensitivity metric, based on the variance statistic, was developed using well-characterized, large-pitch (0.80 μm) photoresist grating structures on Si illuminated at 633 and 442 nm. The same metric was applied to short-pitch (0.20 μm), etched gratings on InP, with the result that appreciable scatterometry sensitivity was measured, even at the 633 nm incident wavelength. Modeling was used to estimate scatterometry sensitivity at three wavelengths for photoresist critical dimensions of 100 and 70 nm on Si. A significant increase in sensitivity was not found until the incident wavelength was reduced to 325 nm. We are presently investigating techniques to improve measurement sensitivity for short-pitch structures using the 633 nm incident wavelength.
Antiepileptic and antiamnesic effect of carbamazepine in experimental limbic epilepsy. (1985)

Carbamazepine (20 mg/kg, 40 mg/kg or 60 mg/kg) given three times a day, has been demonstrated to have a significant anti-epileptic effect in rats with chronic limbic epilepsy induced by injecting tetanus toxin bilaterally into their hippocampi. This effect involved a reduction in the maximum number of fits occurring on one day, and with the highest dose, a significant reduction in the total number of fits. In a pilot experiment in which continuous EEG records were obtained throughout the syndrome, it appeared that the effect of carbamazepine was to reduce the proportion of EEG seizure discharges which lead to overt motor fits. With the higher drug dose plasma levels of carbamazepine were maintained around 2 micrograms/ml. This experimental epilepsy produces enduring deficits in the rats' memories for a light-discrimination task in a Y-maze learned before induction of epilepsy (8 weeks after initial learning). If the rats are dosed with carbamazepine during their epilepsy this memory deficit is abolished.
ChemInform Abstract: Catalyst Preparation Using Plasma Technologies (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<scp>mi</scp> RNA: Licensed to Kill the Messenger (2007)

Current developments have brought non-coding genes under limelight together with their better-known siblings, the coding genes or mRNA. The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Fire and Craig Mello for their 1998 discovery that double-stranded RNA triggers suppression of gene activity in a homology-dependent manner, a process named RNA interference (RNAi). Post-transcriptional regulation of genes was generally regarded as an odd regulatory mechanism for several years until it was learnt that regulatory trans-acting antisense RNAs exist in several species. Identification of a large number of small RNA molecules called microRNAs (miRNAs) elevated the overall field of biomedical RNAi to the striking level of current recognition. miRNAs represent a class of endogenous small ( approximately 22 nucleotides) RNA molecules that can repress protein synthesis. It is estimated that there are over 600 miRNAs in mammalian cells, and that about 30% of all genes are regulated by miRNA. Current understanding of the molecular mechanism of any disease would be incomplete without factoring in the functional significance of miRNA. In the category of the futuristic RNAi drugs, miRNA-based therapies are promising. The field has progressed rapidly as it relates to cancer research (highlighted in DNA and Cell Biology Volume 26, Number 4), while development in most other areas (highlighted in DNA and Cell Biology Volume 26, Number 3) of biomedical research remains in its infancy, offering significant opportunity for researchers. Approaches to interfere with miRNA function in vivo offer novel therapeutic opportunities. Lessons in gene therapy have taught us that tinkering with the genetic machinery comes with its own set of risks, especially in a clinical setting. miRNA-based therapies are also subject to such risks, which need to be prudently managed. Having acknowledged the potential risk, we have to recognize that new knowledge about the functional roles of miRNA is revolutionizing cell biology and will have a major impact on biomedical research imminently.
Modified surveillance of influenza A(H1N1)v virus infections in France (2009)

Up to early July 2009, surveillance of H1N1 cases in France was based on the identification of all possible cases in order to implement, around each of them, control measures aimed at delaying the spread of the virus. The global dissemination of the virus and the starting community transmission in France led us to shift to a population-based surveillance relying mainly on the identification and investigation of clusters of influenza-like illness, on the identification and individual follow-up of confirmed hospitalised cases as well as on the monitoring, through various sentinel systems, of the use of ambulatory and hospital care for influenza-like symptoms.
New privacy issues in mobile telephony (2012)

Mobile telephony equipment is daily carried by billions of subscribers everywhere they go. Avoiding linkability of subscribers by third parties, and protecting the privacy of those subscribers is one of the goals of mobile telecommunication protocols. We use formal methods to model and analyse the security properties of 3G protocols. We expose two novel threats to the user privacy in 3G telephony systems, which make it possible to trace and identify mobile telephony subscribers, and we demonstrate the feasibility of a low cost implementation of these attacks. We propose fixes to these privacy issues, which also take into account and solve other privacy attacks known from the literature. We successfully prove that our privacy-friendly fixes satisfy the desired unlinkability and anonymity properties using the automatic verification tool ProVerif.
Quantum Artificial Life in an IBM Quantum Computer (2018)

We present the first experimental realization of a quantum artificial life algorithm in a quantum computer. The quantum biomimetic protocol encodes tailored quantum behaviors belonging to living systems, namely, self-replication, mutation, interaction between individuals, and death, into the cloud quantum computer IBM ibmqx4. In this experiment, entanglement spreads throughout generations of individuals, where genuine quantum information features are inherited through genealogical networks. As a pioneering proof-of-principle, experimental data fits the ideal model with accuracy. Thereafter, these and other models of quantum artificial life, for which no classical device may predict its quantum supremacy evolution, can be further explored in novel generations of quantum computers. Quantum biomimetics, quantum machine learning, and quantum artificial intelligence will move forward hand in hand through more elaborate levels of quantum complexity.