gebhart/patrepeval huggingface dataset:
Reciprocal regulation of Notch and PI3K/Akt signalling in T‐ALL cells In Vitro (2007)

Notch signalling plays an important role in hematopoiesis and in the pathogenesis of T-ALL. Notch is known to interact with Ras and PTEN/PI3K (phosphoinositide-3 kinase)/Akt pathways. We investigated the interaction of Notch with these pathways and the possible reciprocal regulation of these signalling systems in T-ALL cells in vitro. Our analyses indicate that the PI3K/Akt pathway is constitutively active in the four T-ALL cell lines tested. Akt phosphorylation was not altered by the sequestration of growth factors, that is, Akt activation seems to be less dependent on but not completely independent of growth factors, possibly being not subject to negative feedback regulation. PTEN expression was not detected in 3/4 cell lines tested, suggesting the loss of PTEN-mediated Akt activation. Inhibition of the PI3K/Akt pathway arrests growth and enhances apoptosis, but with no modulation of expression of Bax-alpha and Bcl-2 proteins. We analysed the relationship between Notch-1 and the PI3K/Akt signalling and show that inhibition of the Akt pathway changes Notch expression; Notch-1 protein decreased in all the cell lines upon treatment with the inhibitor. Our studies strongly suggest that Notch signalling interacts with PI3K/Akt signalling and further that this occurs in the absence of PTEN expression. The consequences of this to the signalling outcome are yet unclear, but we have uncovered a significant inverse relationship between Notch and PI3K/Akt pathway, which leads us to postulate the operation of a reciprocal regulatory loop between Notch and Ras-PI3K/Akt in the pathogenesis of T-ALL.
Flight test development and evaluation of a Kalman filter state estimator for low-altitude flight (2002)

Flight operations dependent on digitized terrain elevation data for navigational reference or trajectory generation are constrained in minimum flight altitude, due to airborne navigation errors and inaccuracies of the reference terrain elevation data. This limitation is not restrictive in traditional medium-altitude implementations of such databases, such as in unmanned aerial vehicles, missiles, or high-performance, high-speed aircraft. In low-altitude, lower speed terrain hugging helicopter missions, however, such constraints on minimum flight altitudes greatly reduce the effectiveness of their missions and diminish the benefits of employing terrain elevation maps. A Kalman filter state estimator has been developed which blends airborne navigation, stored terrain elevation data, and a radar altimeter in estimating above-ground-level (AGL) altitude. This AGL state estimator was integrated in a near-terrain guidance system aboard a research helicopter and flight tested in moderately rugged terrain over a variety of flight and system conditions. The minimum operating altitude of the terrain database referenced guidance system was reduced from 300 ft to 150 ft with the addition of this Kalman filter state estimator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
ChemInform Abstract: 3‐Alkanoyl‐5‐hydroxymethyl Tetronic Acid Homologues and Resistomycin: New Inhibitors of HIV‐1 Protease. Part 1. Fermentation, Isolation and Biological Activity. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hacking the Nintendo Wii Remote (2008)

Since its introduction, the Nintendo Wii remote has become one of the world's most sophisticated and common input devices. Combining its impressive capability with a low cost and high degree of accessibility make it an ideal platform for exploring a variety of interaction research concepts. The author describes the technology inside the Wii remote, existing interaction techniques, what's involved in creating custom applications, and several projects ranging from multiobject tracking to spatial augmented reality that challenge the way its developers meant it to be used.
The Evolution of Title IX: Prospects for Equality in Intercollegiate Athletics (1981)

This Comment will analyze the development of Title IX, as it affects female athletes, from its inception in 1972 to the publication by the Department of Health, Education and Welfare (HEW) of the final policy interpretation in December of 1979. In particular, the final policy will be carefully scrutinized to determine whether it is consistent with and, more specifically, how well it serves the important public policy goals which informed the statute. Although the analysis will reveal weaknesses in HEW's policy, specific remedies are suggested which will aid in ensuring equal opportunity for intercollegiate sportswomen.
Analysis of the ULF electromagnetic emission related to seismic activity, Teoloyucan geomagnetic station, 1998-2001 (2004)

Abstract. Results of ULF geomagnetic measurements at station Teoloyucan (Central Mexico, 99.11'35.735''W, 19.44'45.100''N, 2280m height) in relation to seismic activity in the period 1998-2001 and their analysis are presented. Variations of spectral densities for horizontal and vertical components, polarization densities and spectrograms of magnetic field, their derivatives are analyzed as a part of traditional analysis in this study. Values of spectral density were calculated for 6 fixed frequencies f=1, 3, 10, 30, 100 and 300mHz. Fractal characteristics of spectra were analyzed in the conception of SOC (Self-Organized Criticality). 2 nighttime intervals, 0-3 and 3-6h by local time have been used to decrease the noise interference in row data. In order to exclude the intervals with a high geomagnetic activity from analysis we referred to Ap indices, calculated for corresponding time intervals. The contribution of seismic events to geomagnetic emission was estimated by seismic index ks=100.75Ms/10D, where Ms is the amplitude of the earthquake and D is the distance from its epicenter to the station.
Angiotensin Selectively Activates a Subpopulation of Postganglionic Sympathetic Neurons in Mice (2001)

Angiotensin II (Ang II) increases renal sympathetic nerve activity in anesthetized mice before and after ganglionic blockade, suggesting that Ang II may directly activate postganglionic sympathetic neurons. The present study directly tested this hypothesis in vitro. Neurons were dissociated from aortic-renal and celiac ganglia of C57BL/6J mice. Cytosolic Ca(2+) concentration ([Ca(2+)](i)) was measured with ratio imaging using fura 2. Ang II increased [Ca(2+)](i) in a subpopulation of sympathetic neurons. At a concentration of 200 nmol/L, 14 (67%) of 21 neurons responded with a rise in [Ca(2+)](i). The Ang II type 1 (AT(1)) receptor blocker (losartan, 2 micromol/L) but not the Ang II type 2 (AT(2)) receptor blocker (PD123,319, 4 micromol/L) blocked this effect. The Ang II-induced [Ca(2+)](i) increase was abolished by removal of extracellular Ca(2+) but not altered by depletion of intracellular Ca(2+) stores with thapsigargin. Ang II no longer elicited a [Ca(2+)](i) increase in the presence of lanthanum (25 micromol/L). The specific N-type and L-type Ca(2+) channel blockers, omega-conotoxin GVIA and nifedipine, respectively, significantly inhibited the Ang II-induced [Ca(2+)](i) increase. The protein kinase C inhibitor H7 but not the protein kinase A inhibitor H89 blocked the response to Ang II. These results demonstrate that Ang II selectively activates a subpopulation of postganglionic sympathetic neurons in aortic-renal and celiac ganglia, triggering Ca(2+) influx through voltage-gated Ca(2+) channels. This effect is mediated through AT(1) receptors and requires the activation of protein kinase C. The activation of a subgroup of sympathetic neurons by Ang II may exert unique effects on kidney function in pathological states associated with elevated Ang II.
Novel volatiles in pineapple fruit and their sensory properties (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel volatiles in pineapple fruit and their sensory propertiesRalf G. Berger, Friedrich Drawert, Hubert Kollmannsberger, Siegfried Nitz, and Bernhard SchraufstetterCite this: J. Agric. Food Chem. 1985, 33, 2, 232–235Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/jf00062a019https://doi.org/10.1021/jf00062a019research-articleACS PublicationsRequest reuse permissionsArticle Views389Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design of Contact‐Active Antimicrobial Acrylate‐Based Materials Using Biocidal Macromers (2007)

A self organizing antimicrobial finish on acrylate-based materials was achieved by adding only 0.4 wt% of a biocidal macromer to the monomer mixture prior polymerization. The materials surface kills the infectious bacterium Staphylococcus aureus without releasing the biocide (Figure, lower section) and stays active even after 45 d of constant washing. Confocal Raman spectroscopy and fluorescence microscopy (Figure, upper section) reveal that the biocide has migrated to the surface of the materials during polymerization.
Visual Analysis of Multi‐Joint Kinematic Data (2010)

Abstract Kinematics is the analysis of motions without regarding forces or inertial effects, with the purpose of understanding joint behaviour. Kinematic data of linked joints, for example the upper extremity, i.e. the shoulder and arm joints, contains many related degrees of freedom that complicate numerical analysis. Visualisation techniques enhance the analysis process, thus improving the effectiveness of kinematic experiments. This paper describes a new visualisation system specifically designed for the analysis of multi‐joint kinematic data of the upper extremity. The challenge inherent in the data is that the upper extremity is comprised of five cooperating joints with a total of fifteen degrees of freedom. The range of motion may be affected by subtle deficiencies of individual joints that are difficult to pinpoint. To highlight these subtleties our approach combines interactive filtering and multiple visualisation techniques. Our system is further differentiated by the fact that it integrates simultaneous acquisition and visual analysis of biokinematic data. Also, to facilitate complex queries, we have designed a visual query interface with visualisation and interaction elements that are based on the domain‐specific anatomical representation of the data. The combination of these techniques form an effective approach specifically tailored for the investigation and comparison of large collections of kinematic data. This claim is supported by an evaluation experiment where the technique was used to inspect the kinematics of the left and right arm of a patient with a healed proximal humerus fracture, i.e. a healed shoulder fracture.
Raising high-density lipoprotein cholesterol for better prevention of cardiovascular disease (2006)

A substantial body of evidence supports the benefits of lipid lowering on cardiovascular outcome. As a consequence, statin therapy has emerged as the foundation for management of dyslipidemia in high-risk patients. Despite these achievements, two-thirds of cardiovascular events cannot be prevented by lowering low-density lipoprotein (LDL) cholesterol levels according to current guidelines. Although LDL remains one of the most important factors in atherogenesis, research has shifted beyond the LDL particle and includes other lipoproteins that may contribute to cardiovascular disease risk, such as low levels of high-density lipoprotein (HDL) cholesterol and elevated triglyceride (TG) levels. Together with the growing epidemic of obesity-induced dyslipidemia, mainly consisting of low HDL levels and elevated TGs, strategies to increase HDL levels are beginning to emerge as an attractive tool for better cardiovascular protection. In the future, a comprehensive approach for optimal cardiovascular risk management will probably include both lifestyle modifications and intensive LDL-lowering therapy combined with potent HDL increasing agents.
LONG‐TERM RESULTS OF THE MULTICHANNEL COCHLEAR IMPLANTa (1983)

Clinical results obtained with the multichannel cochlear implant are described in 48 cases of total deafness (27 cases of prelingual and 21 cases of postlingual deafness). The tolerance for implanted material and the survival of the electrode-nerve interface have not yet been altered after more than 5 years. After some months of training the patients, the percentages of phoneme-, word-, and sentence-recognition vary from one patient to another, but depend approximately on the value of the threshold level of the round-window stimulation test, and the degree of socialization of each patient. These results suggest that the multichannel cochlear implant may now be considered as a useful tool in the rehabilitation of totally deaf persons.
Synthesis of N-Substituted C-Normorphinans and Their Pharmacological Properties. (1992)

Several N-substituted C-normorphinans (VIII and IX) were synthesized and tested for their analgetic and narcotic antagonist activities and physical dependence capacity. Treatment of N-formyl- octahydro-2-pyrindine (IIIc) with polyphosphoric acid readily gave N-formyl-C-normorphinan (IV). The N-nor bases (V and VII) obtained from IV were converted to VIII and IX. The N-methyl derivative (I), which was previously reported to be inactive by Haffner's method, exhibited potent analgetic activity by the hot plate method and the AcOH-induced writhing test. Compounds VIII and IX showed pharmacological properties similar to those of N-substituted morphinans and exhibited agonist (analgetic) and/or narcotic antagonist activities. The C-nor analogue (IXa) of cyclorphan (IIc) exhibited potent analgetic and antagonist activities with no physical dependence capacity in the single-dose suppression tests both in rats and monkeys.
Prostaglandin-dependent changes in renal haemodynamics and excretory patterns before and after release of 24 hours bilateral ureteral ligation. (1980)

In the anesthetized dog during and 1 hr after release of 24 h bilateral ureteral ligation (BUL) renal blood flow (RBF) decreased to 44 and 51%, respectively, as compared with normal controls. After release there was a marked increase in sodium and water excretion, so-called postobstructive diuresis (POD), in spite of a considerably reduced glomerular filtration rate (GFR). Radioactive microspheres revealed a proportionate decrease of perfusion in all cortical layers before, and inward shifting after release of the ligature. Inhibition of intrarenal prostaglandin (PF) synthesis by indomethacin (IM) before release of BUL led to a further pronounced decrease in RBF both in the pre- and postrelease phases, characterized by a proportionate decrease of perfusion in all cortical layers. Fractional excretion of sodium and water remained moderately increased in spite of a very pronounced hypofiltration. It is assumed that, in contrast to PG-dependent changes in renal haemodynamics due to BUL, enhanced sodium and water excretion (POD) are due to a PG-independent mechanism, most probably to some natriuretic substance produced and/or accumulated during 24 h complete retention.
Forecasting of air quality in Delhi using principal component regression technique (2011)

Over the past decade, an increasing interest has evolved by the public in the day–to–day air quality conditions to which they are exposed. Driven by the increasing awareness of the health aspects of air pollution exposure, especially by most sensitive sub–populations such as children and the elderly, short–term air pollution forecasts are being provided more and more by local authorities. The Air Quality Index (AQI) is a number used by governmental agencies to characterize the quality of the air at a given location. AQI is used for local and regional air quality management in many metropolitan cities of the world. The main objective of the present study is to forecast short–term daily AQI through previous day’s AQI and meteorological variables using principal component regression (PCR) technique. This study has been made for four different seasons namely summer, monsoon, post monsoon and winter. AQI was estimated for the period of seven years from 2000–2006 at ITO (a busiest traffic intersection) for criteria pollutants such as respirable suspended particulate matter (RSPM), sulfur dioxide (SO2), nitrogen dioxide (NO2) and suspended particulate matter (SPM) using a method of US Environmental Protection Agency (USEPA), in which sub–index and breakpoint pollutant concentration depends on Indian National Ambient Air Quality Standard (NAAQS). The Principal components have been computed using covariance of input data matrix. Only those components, having eigenvalues ≥ 1, were used to predict the AQI using principal component regression technique. The performance of PCR model, used for forecasting of AQI, was better in winter than the other seasons as studied through statistical error analysis. The values of normalized mean square error (NMSE) were found as 0.0058, 0.0082, 0.0241 and 0.0418 for winter, summer, post monsoon and monsoon respectively. The other statistical parameters are also supporting the same result.
Notes On Writing Portable Programs In C (1994)

This documents describes the features and non-features of different C preprocessors, compilers, and environments. As such, it is an incomplete document, growing as information is gathered. It contains some material concerning ANSI C but it is not a substitute for the Standard itself; neither are related textbooks. We assume the reader is familiar with the C programming language. Internet: ado@sauna.hut.fi. y Internet: pardo@cs.washington.edu. z Internet: gvr@cs.brown.edu. 2 Contents 1 Foreword 4 2 Introduction 4 3 Standardization Efforts 5 3.1 ANSI C : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 5 3.1.1 Translation Limits : : : : : : : : : : : : : : : : : : : : 5 3.1.2 Unspecified and Undefined Behavior : : : : : : : : : : 7 3.2 POSIX : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 7 4 Preprocessors 7 4.1 Command Options : : : : : : : : : : : : : : : : : : : : : : : : 8 4.2 #pragma and #elif : : : : : : : : : : : : : : : : : : : : : : : : 8 4.3 ...
Cyclization and oxidation of N-substituted phenyl-N’-(2-methyl-3-phenylpropenoyl)thioureas (1991)

The synthesis of 1,3-thiazines, 2-thiouracils and ureas from N-substituted phenyl-N’-(2-methyl-3-phenylpropenoyl)thioureas by intramolecular cyclization or oxidation under various conditions is described. The structure of products was verified by IR, 1 H NMR and mass spectral evidence.
Ethernet Networking Clearly Explained (1999)

Preface INTRODUCTION Introduction How Ethernet Works TRANSMISSION MEDIA AND NETWORK CONNECTIONS Standard (10 Mbps) Ethernet Fast and Gigabit Ethernet Connecting Network Segments Integrating Wireless Transmissions EQUIPPING AN ETHERNET WITH HARDWARE AND SOFTWARE Network Devices Network Protocols and Operating Systems Peer-to-Peer Networking Integrating Multiple Operating Systems Network Monitoring and Discovery ETHERNET SOLUTION EXAMPLES Network Design and Simulation Software Ethernet Example 1: Small-But-Growing Real Estate Ethernet Example 2: Medium Law Firm Ethernet Example 3: Large Insurance Company Appendix A: Home Networking Appendix B: Vendor List Glossary Index
TbPDE1, a novel class I phosphodiesterase of <i>Trypanosoma brucei</i> (2004)

Cyclic nucleotide specific phosphodiesterases (PDEs) are important components of all cAMP signalling networks. In humans, 11 different PDE families have been identified to date, all of which belong to the class I PDEs. Pharmacologically, they have become of great interest as targets for the development of drugs for a large variety of clinical conditions. PDEs in parasitic protozoa have not yet been extensively investigated, despite their potential as antiparasitic drug targets. The current study presents the identification and characterization of a novel class I PDE from the parasitic protozoon Trypanosoma brucei, the causative agent of human sleeping sickness. This enzyme, TbPDE1, is encoded by a single-copy gene located on chromosome 10, and it functionally complements PDE-deficient strains of Saccharomyces cerevisiae. Its C-terminal catalytic domain shares about 30% amino acid identity, including all functionally important residues, with the catalytic domains of human PDEs. A fragment of TbPDE1 containing the catalytic domain could be expressed in active form in Escherichia coli. The recombinant enzyme is specific for cAMP, but exhibits a remarkably high Km of > 600 microm for this substrate.
Investigation of Hand Motion Language in Shape Conceptualization (2004)

This paper summarizes the results of an empirical study concerning the use of hand motions as one of the input mechanisms of a multi-modal interface of computer aided conceptual design systems for initial shape design of consumer durables. A hand motion language (HML) has been developed and used in designed experiments to describe simple, compound and hybrid shapes. The subjects were asked to reconstruct the presented shapes by sketching on paper. Comprehension of the hand motion language has been evaluated in terms of fidelity and efficiency. The results clearly indicate the potentials of a HML in shape conceptualization. In addition, the experiments revealed several new issues related to the application of the hand motion language in a multi-modal interface.
Enhanced Flocculation of Oil Sands Mature Fine Tailings Using Hydrophobically Modified Polyacrylamide Copolymers (2018)

Hydrophobically modified acrylamide copolymers dewater oil sands tailings more effectively than anionic polyacrylamide, but the root causes for this enhanced performance have not been investigated systematically. Polyacrylamide-poly(ethylene oxide methyl ether methacrylate) copolymers with different comonomer compositions, hydrophobic chain lengths, and molecular weights to map out these effects systematically are synthetized. Through a statistical design of experiments, it is found out that all three variables above significantly affected flocculation performance and that certain combinations achieve optimal results. The effect of centrifugation on the flocculation and dewatering performance of these polymers is also investigated.
Moral Stress, Moral Practice, and Ethical Climate in Community-Based Drug-Use Research: Views From the Front Line (2013)

Applying psychometrically reliable scales to empirically examine research ethics challenges can illuminate specific threats to scientific integrity and human subjects protections encountered by front-line staff and suggest organizational strategies for reducing moral stress and enhancing the responsible conduct of research.