gebhart/patrepeval huggingface dataset:
Research of Collaborative Design Task Management Method Based on Grid (2010)

In the coordination design support environment full use network resources carry on the coordination work, realizes the different person to design the identical product together the goal. In the coordination design process, a complex task is decomposed to small sub-tasks with certain granularity and assigns each sub-task for in the suitable grid node completes by the suitable person. The entire product design process is one kind of lamination nesting structure, its design task decomposition is whether reasonable, will directly affect the product design flow and the design cycle, moreover the task coupling relations will involve the design change dissemination and the design recollection, therefore, will have to carry on the coordination and the control to each sub-task advancement, under certain rule control each task distribution for the different design personnel, will avoid as far as possible with the reduced coordination design process in the conflict, thus the guarantee coordination design overall task will complete smoothly. This article has studied the task theory of dissociation, has given the product coordination design task concrete decomposition method, uses the design structure matrix to judge the rationality which the task decomposes and to the task to carry on the reorganization, gives the coupling task collection the decoupling method. Finally, it has given the task plan function module network realization flow.
An Outbreak of Mycobacterial Furunculosis Associated with Footbaths at a Nail Salon (2002)

We identified a large outbreak of rapidly growing mycobacterial infections among persons who had had footbaths and pedicures at one nail salon. Physicians should suspect this cause in patients with persistent furunculosis after exposure to whirlpool footbaths.
The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen. (1983)

Cultured fibroblasts were examined from a patient with a nonlethal form of osteogenesis imperfecta. As reported previously (Nicholls, A. C., Pope, F. M., and Schloon, H. (1979) Lancet 1, 1193), the cells synthesized and secreted a type I procollagen which lacked pro-alpha 2(I) chains and consisted of a trimer of pro-alpha 1(I) chains. No pro-alpha 2(I) chains were recovered from the medium under conditions in which nonhelical pro-alpha 1(I) and pro-alpha 2(I) chains were readily detected in the medium of normal fibroblasts incubated with the hydroxylase inhibitor, alpha, alpha'-dipyridyl. Examination of cellular proteins demonstrated that the fibroblasts synthesized both pro-alpha 1(I) and pro-alpha 2(I) chains. The cellular pro-alpha 2(I) chains did not, however, become disulfide-linked into dimers or trimers of pro-alpha chains. Since the association of pro-alpha chains during the biosynthesis of type I procollagen is directed by the conformation of the COOH-terminal propeptides, the data suggest that the pro-alpha 2(I) chains synthesized by the fibroblasts have a mutated structure in the COOH-terminal propeptides which markedly reduces their affinity for pro-alpha 1(I) chains. A further observation was that the ratio of newly synthesized pro-alpha (I):pro-alpha 2(I) chains in the patient's fibroblasts was 7.18 +/- 0.58 S.E. instead of the value of 2.25 +/- 0.16 S.E. seen in control fibroblasts. One possible explanation for the high ratio is that the proband is homozygous for a mutation altering the structure of the pro-alpha 2(I) chain and that a secondary effect of the structural mutation is a decreased rate of synthesis of pro-alpha 2(I) chains.
Vasopressin receptors modulate the pharmacological phenotypes of cushing's syndrome (1998)

We have examined the expression profiles of the different vasopressin receptors (V1, V2, V3) that can be expressed in the three different types of tumors associated with Cushing's syndrome. V3 (V1b) receptor cDNA was cloned from a pituitary tumor responsible for Cushing's disease. We show that it is overexpressed in these tumors and can respond to DD-AVP. High expression of the V3 receptor on highly differentiated, ACTH-secreting, bronchial carcinoid tumors explain why these non-pituitary tumors occasionally respond to vasopressin, mimicking a "pituitary-like" behavior. A retrospective analysis showed that vasopressin induced an ACTH-independent cortisol rise in 27% of the adrenocortical tumors responsible for Cushing's syndrome. V1 mRNA was detected in normal adrenal cortex and in all tumors. Adenomas had significantly higher levels than carcinomas. V1 mRNA levels were higher in responders than in non-responders. One adenoma which had a brisk cortisol response in vivo, also had in vitro cortisol responses that were inhibited by a specific V1 antagonist. In situ hybridization showed the presence of V1 mRNA in the normal human adrenal cortex where the signal predominated in the compact cells of the zona reticularis. A positive signal was also present in the tumors with high V1 mRNA levels determined by RT-PCR; its distribution pattern was heterogeneous and showed preferential association with compact cells. High-and not ectopic-expression of the V1 receptor occurs in a minority of adrenal cortical tumors which become directly responsive to vasopressin stimulation.
Lessons learned studying design issues for lunar and Mars settlements. (1997)

In a study of lunar and Mars settlement concepts, an analysis was made of fundamental design assumptions in five technical areas against a model list of occupational and environmental health concerns. The technical areas included the proposed science projects to be supported, habitat and construction issues, closed ecosystem issues, the "MMM" issues (mining, material processing, and manufacturing), and the human elements of physiology, behavior, and mission approach. Four major lessons were learned. First it is possible to relate public health concerns to complex technological development in a proactive design mode, which has the potential for long-term cost savings. Second, it became very apparent that prior to committing any nation or international group to spending the billions to start and complete a lunar settlement, over the next century, that a significantly different approach must be taken from those previously proposed, to solve the closed ecosystem and "MMM" problems. Third, it also appears that the health concerns and technology issues to be addressed for human exploration into space are fundamentally those to be solved for human habitation of the Earth (as a closed ecosystem) in the 21st century. Finally, it is proposed that ecosystem design modeling must develop new tools, based on probabilistic models as a step up from closed circuit models.
Investigation of dynamic properties of erbium fiber laser for ultrasonic sensing (2014)

Dynamic properties of an erbium fiber laser (EFL) is researched and demonstrated for ultrasonic sensing in this research. The EFL has ring cavity incorporated with a phase-shifted fiber Bragg grating. A numerical model is used to analyze its dynamic responses to quasi-static change, continuous wave and burst wave. The ultrasonic behavior of the EFL resembles the forced single degree of freedom vibration with damping. Corresponding experimental results fit the simulation results well, showing some interesting ultrasonic properties of this EFL. After certain data process method, this EFL can be used in practical ultrasonic nondestructive testing.
Epidemiology of Japanese Cedar Pollinosis: Result of the Survey in Mibu-machi. (1999)

The prevalence rate of Japanese cedar pollinosis has increased since 1979. We conducted a survey of the residents of Mibu-mach, Tochigi, in 1988 and 1996 using a questionnaire to determine the prevalence rate of cedar pollinosis. Results showed its rate was 15.6% in 1988, and 25.6% in 1996. Age distribution analysis of patients with Japanese cedar pollinosis showed the highest prevalence in patients between the ages of 10 to 49 years in 1988, and between the ages of 10 to 59 years old in 1996. Within these age groups, the majority of the patients were females, but males were more prevalent than females in the age group under 19 years old. The prevalence rate of patients by age group revealed the same pattern as the age distribution of the patients. Age distribution of cedar pollinosis showed a peak in patients in their thirties both in 1988 and 1996. In conclusion, the numbers of patients with Japanese cedar pollinosis has been increasing remarkably in Mibu-mach. As climate or environmental conditions are varied in different geographical regions in Japan, further epidemiological studies in various regions of the country are required to clarify the actual prevalence rate of cedar pollinosis.
A New Possibility of the Generalized Two-Dimensional Correlation Spectroscopy. 1. Sample−Sample Correlation Spectroscopy (2000)

In this paper an extension of the generalized two-dimensional (2D) correlation spectroscopy, sample−sample correlation spectroscopy, is proposed to obtain the information about the species' perturbation-dependent dynamics. This is the first report of monitoring perturbation dynamics in the samples by generalized 2D approach. After the rows and columns of the experimental matrix are exchanged in a way that the spectral data set is arranged in rows, unlike the common case, the correlation between the concentrations of species is calculated. The method has been applied to a model system consisting of two bands with different degrees of overlapping. The concentration-dependent dynamics of the components that give rise to the two bands has been successfully analyzed. Similarities, differences, and correspondences between wavenumber−wavenumber correlation spectroscopy (existing generalized 2D correlation spectroscopy) and sample−sample correlation spectroscopy have been discussed. The pretreatments of mean normalization and mean centering seem to yield the best results. The application of the presently proposed sample−sample correlation spectroscopy gives correct results probably irrespective of the ratio of the band intensities, as is revealed in the analysis of highly overlapped infrared (IR) spectra in the region of 3200−2700 cm-1 artificially synthesized from two polymer spectra.
Ostro: Scalable Placement Optimization of Complex Application Topologies in Large-Scale Data Centers (2015)

A complex cloud application consists of virtual machines (VMs) running software such as web servers and load balancers, storage in the form of disk volumes, and network connections that enable communication between VMs and between VMs and disk volumes. The application is also associated with various requirements, including not only quantities such as the sizes of the VMs and disk volumes, but also quality of service (QoS) attributes such as throughput, latency, and reliability. This paper presents Ostro, an Open Stack-based scheduler that optimizes the utilization of data center resources, while satisfying the requirements of the cloud applications. The novelty of the approach realized by Ostro is that it makes holistic placement decisions, in which all the requirements of an application -- described using an application topology abstraction -- are considered jointly. Specific placement algorithms for application topologies are described including an estimate-based greedy algorithm and a time-bounded A algorithm. These algorithms can deal with complex topologies that have heterogeneous resource requirements, while still being scalable enough to handle the placement of hundreds of VMs and volumes across several thousands of host servers. The approach is evaluated using both extensive simulations and realistic experiments. These results show that Ostro significantly improves resource utilization when compared with naive approaches.
Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain (1998)

Alzheimer's disease (AD) is a major dementing illness characterized by regional concentrations of senile plaques, neurofibrillary tangles, and extensive neuronal cell death. Although cell and synaptic loss is most directly linked to the severity of symptoms, the mechanisms leading to the neuronal death remain unclear. Based on evidence linking neuronal death during development to unexpected reappearance of cell cycle events, we investigated the brains of 12 neuropathologically verified cases of Alzheimer's disease and eight age-matched, disease-free controls for the presence of cell cycle proteins. Aberrant expression of cyclin D, cdk4, proliferating cell nuclear antigen, and cyclin B1 were identified in the hippocampus, subiculum, locus coeruleus, and dorsal raphe nuclei, but not inferotemporal cortex or cerebellum of AD cases. With only one exception, control subjects showed no significant expression of cell cycle markers in any of the six regions. We propose that disregulation of various components of the cell cycle is a significant contributor to regionally specific neuronal death in AD.
Comparison of Sodium Iodide, Cesium Iodide, and Bismuth Germanate Scintillation Detectors for Borehole Gamma-Ray Logging (1981)

NaI(Tl), CsI(Na), and Bi4Ge3O12 detectors were installed in borehole probes and used to collect gamma-ray data at the U.S. Department of Energy's calibration facility at Grand Junction, Colorado. Spectral data were collected with all three detectors to determine their ability to assay 40K, 214Bi (a decay product of uranium) and 208Tl (a decay product of thorium). Gross count data were also obtained with small NaI(Tl) and Bi4Ge3O12 detectors. Both CsI(Na) and Bi4Ge3O12M/(bismuth germanate abbreviated "BGO") offer enhanced gamma-ray counting efficiency over that provided by NaI(Tl) which is the most common scintillator used in uranium exploration. Tests in calibration boreholes showed that CsI(Na) averaged 45 percent higher spectral counting efficiency than did the same size NaI(Tl) detector. BGO gave an average spectral counting efficiency 310 percent higher than did NaI(Tl). In addition, both BGO and CsI(Na) displayed smaller stripping ratios than did NaI(Tl) due to increased photopeak efficiencies. Consequently CsI(Na) and BGO provided precisions in spectral assays which were better by 20 percent and 55 percent, respectively, than the precisions obtained from NaI(Tl) detectors of the same size with the same counting times. For gross count applications BGO produced a count rate 50 percent greater than did the same size NaI(Tl) detector in an unfiltered gamma-ray probe. When a graded filter was placed around the detectors to reduce the number of low energy gamma rays detected, the count rate obtained from BGO was 90 percent greater than from Nal(Tl).
Determination of the Yield Stress of Semi‐Liquid Foods from Squeezing Flow Data (1987)

ABSTRACT The yield stress of tomato paste, ketchup, mustard, and mayonnaise was determined from the thickness vs time relationships of squeezed samples having constant area under constant force. The results were virtually independent of the force imposed and the initial thickness of the samples. The readings were in agreement with values determined from shear flow using a coaxial viscometer.
<title>Fabrication issues of oxide-confined VCSELs</title> (1997)

To insert high performance oxide-confined vertical-cavity surface-emitting lasers (VCSELs) into the manufacturing arena, we have examined the critical parameters that must be controlled to establish a repeatable and uniform wet thermal oxidation process for AlGaAs. These parameters include the AlAs mole fraction, the sample temperature, the carrier gas flow and the bubbler water temperature. Knowledge of these critical parameters has enabled the compilation of oxidation rate data for AlGaAs which exhibits an Arrhenius rate dependence. The compositionally dependent activation energies for Al<SUB>x</SUB>Ga<SUB>1-x</SUB>As layers of x equals 1.00, 0.98 and 0.92 are found to be 1.24, 1.75, and 1.88 eV, respectively.
Targeting MTHFD2 in acute myeloid leukemia (2016)

Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2), emerged as a top candidate in our analyses. MTHFD2 is the most differentially expressed metabolic enzyme in cancer versus normal cells. Knockdown of MTHFD2 in AML cells decreased growth, induced differentiation, and impaired colony formation in primary AML blasts. In human xenograft and MLL-AF9 mouse leukemia models, MTHFD2 suppression decreased leukemia burden and prolonged survival. Based upon primary patient AML data and functional genomic screening, we determined that FLT3-ITD is a biomarker of response to MTHFD2 suppression. Mechanistically, MYC regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle. This study supports the therapeutic targeting of MTHFD2 in AML.
LONG-TERM QUALITY OF LIFE AFTER KIDNEY TRANSPLANTATION IN CHILDHOOD (1991)

Transplantation is the treatment of choice for children with end-stage renal disease. However, the long-term quality of life and socioprofessional outcome for those with successful transplants have not previously been reported. We studied these factors in patients transplanted when less than 18 years old who currently have greater than or equal to 10 years of graft function. A total of 57 questionnaires were sent out; 57 (100%) responded [24 female and 33 male patients; average (+/- SD) age at tx = 10 +/- 5 years (0.9-17.7); average f/u = 15.6 +/- 3 years (10-26); current age = 26 +/- 5 years (12-38); 26 had greater than 1 transplant]. Of the 57 respondents, 9 are less than 18 (all are in school); 48 are greater than or equal to 18 (7 in school, 37 employed, 4 unemployed); 12 are married, 1 engaged, and 2 divorced; and 9 have children. While in school, 43 (75%) had participated in sports, 37 (65%) in other extracurricular activities; 7 (12%) were A and 33 (58%) B students; 15 (26%) received awards or scholarships. For those working, the range of occupations is broad (average work week = 41 +/- 5 hr). Health-related absence from work has been nonexistent for 93%. Health is rated as good to excellent by 91% and fair by 9%. The future is regarded as hopeful or promising by 80%. Similarly, 89% are satisfied with life in general; 95% said health never or seldom interferes with family life; 95% feel health and drug side effects are of no or minor concern in sexual relationships. Only 3% feel health is a problem in maintaining a sexual relationship (41% are not sexually active). Only 4% stated that health often interferes with social life; 98% meet with friends on a regular basis; 76% are satisfied with personal relationships and 8% dissatisfied; 91% are satisfied with their ability to perform at work or school and 5% dissatisfied. Of note, 32% are dissatisfied with body appearance. Major concerns are short stature and brittle bones. Major suggestions include education/support groups to deal with teasing at school and peer problems. We conclude that transplanted children with long-term graft function have a favorable social and professional outcome. Overall, quality of life seems excellent.
Intrinsic disorder in proteins associated with neurodegenerative diseases (2009)

Neurodegenerative diseases constitute a set of pathological conditions originating from the slow, irreversible and systematic cell loss within the various regions of the brain and/or the spinal cord. Neurodegenerative diseases are proteinopathies associated with misbehavior and disarrangement of a specific protein, affecting its processing, functioning, and/or folding. Many proteins associated with human neurodegenerative diseases are intrinsically disordered; i.e., they lack stable tertiary and/or secondary structure under physiological conditions in vitro. Intrinsically disordered proteins (IDPs) have broad presentation in nature. Functionally, they complement ordered proteins, being typically involved in regulation, signaling and control. Structures and functions of IDPs are intensively modulated by alternative splicing and posttranslational modifications. It is recognized now that nanoimaging offers a set of tools to analyze protein misfolding and self-assembly via monitoring the aggregation process, to visualize protein aggregates, and to analyze properties of these aggregates. The major goals of this review are to show the interconnections between intrinsic disorder and human neurodegenerative diseases and to overview a recent progress in development of novel nanoimaging tools to follow protein aggregation.
Evaluation of Four Methods for Rapid Identification of <i>Staphylococcus aureus</i> from Blood Cultures (1998)

The identification of Staphylococcus aureus directly from blood cultures is clinically relevant, but it requires a test that is both rapid and reliable. Previously, biochemical, immunological, tube coagulase, and thermostable-endonuclease methods have shown variable sensitivity and specificity. Testing directly from blood culture broth has not been described for the latex kit Staphaurex Plus (Murex Diagnostics Ltd.), and the modified conventional tests have not been used with the newer, continuously monitored blood culture systems. In addition, the commercial RAPIDEC staph kit (bioMerieux Vitek, Inc.) has been used to detect S. aureus directly from the Vital blood culture system (bioMerieux, Marcy l'Etoile, France), but its performance has not been evaluated with other continuously monitored systems. A total of 201 clinical blood cultures (BACTEC 9240 culture system; Johnston Laboratories, Inc.) in which a Gram stain showed gram-positive cocci resembling staphylococci were evaluated prospectively. The Staphaurex Plus kit, the tube coagulase test, the thermostable-endonuclease test, and the RAPIDEC staph kit were compared. The sensitivities were 23, 92, 85, and 98% and the specificities were 99, 100, 93, and 100%, respectively. The RAPIDEC staph kit was the most reliable test, with a diagnostic accuracy comparable to that of the best published results for any of the rapid tests. However, it was the most expensive of the tests and relatively labor-intensive. The tube coagulase test was also sensitive, the simplest to perform, and inexpensive.
JICA group training course on mycotoxin inspection in food (2009)

マイコトキシン検査技術研修コースは平成元年度（1989 年度）に発足して以来約20 年間にわたって，独立行政法人国際協力機構兵庫国際センター（旧 国際協力事業団兵庫インターナショナルセンター）において実施されており，これまでに28 カ国から129 名の研修員を受け入れた．本コースは途上国の公的試験検査機関等において食品安全検査業務に携わる技官等に対し，3 ヵ月半の日本滞在期間中に，わが国の食品安全政策の概要，主なマイコトキシンの食品汚染・リスク評価・規制等の講義，及び検査技術や分析法の実習を行うことにより，当該国への技術移転と人材の育成を目的としている．本研修コースを進める中で，これに関連するいくつかのJICA プロジェクトも実施してきた．1995 年にはタイ及びマレーシアにフォローアップ調査団を派遣し，1999 － 2001 年にはブラジル国別特設C/S マイコトキシン検査技術コースを行いブラジル国内におけるマイコトキシンネットワークの構築事業を支援し，さらに2006 年にはアジア地域におけるネットワークの構築を意図してバンコックにおいてフォローアップ・セミナーを実施した．これらのマイコトキシンに係わるJICA 事業の概要と成果をまとめた．
DiagSplit (2009)

We present DiagSplit, a parallel algorithm for adaptively tessellating displaced parametric surfaces into high-quality, crack-free micropolygon meshes. DiagSplit modifies the split-dice tessellation algorithm to allow splits along non-isoparametric directions in the surface's parametric domain, and uses a dicing scheme that supports unique tessellation factors for each subpatch edge. Edge tessellation factors are computed using only information local to subpatch edges. These modifications allow all subpatches generated by DiagSplit to be processed independently without introducing T-junctions or mesh cracks and without incurring the tessellation overhead of binary dicing. We demonstrate that DiagSplit produces output that is better (in terms of image quality and number of micropolygons produced) than existing parallel tessellation schemes, and as good as highly adaptive split-dice implementations that are less amenable to parallelization.