gebhart/patrepeval huggingface dataset:
Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties (2013)

Our data highlight the likelihood that resistant cells emerge from cancer-initiating cells/cancer stem-like cells and imply that these cells may gain further advantage in growth via epigenetic mechanisms. Illuminating the expression and DNA methylation features of putative cancer-initiating cells/cancer stem cells may suggest novel strategies to overcome tamoxifen resistance.
Laminated memory: a new 3-dimensional packaging technology for MCMs (2002)

A new, low-cost, manufacturable process for stacking memory chips up to four-high on a multichip module (MCM) substrate is described. The process is particularly useful when utilized with a high-performance thin-film interconnection substrate ("MCM-D"), as the technique typically enables large (2-4x) reductions in substrate cost for memory-intensive designs, with only a small increment in assembly cost, thereby achieving lower total MCM cost, and greater utilization of the high wiring density and good thermal conductivity of the MCM substrate. The technology was developed and demonstrated using commercially available MCM assembly equipment (dicing, adhesive die attach, and wire bonding equipment). Fully functional memory modules incorporating 2-high stacks have been fabricated, and have passed basic thermal shock tests.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Induced by fibrogenic aerosols, functional peculiarities of external respiration and cardiovascular system]. (2007)

Problem of occupational dust pulmonary diseases is a cardiopulmonologic problem, as pulmonary diseases with bronchial obstruction present with early lung hypertension and subsequent heart failure.
Evaluation of Phytochemical, Chemical Composition, Antioxidant and Antimicrobial Screening Parameters of Rhamnus prinoides (Gesho) Available in the Market of Mekelle, Tigray, Ethiopia (2016)

The objective of this study was the evaluation of phytochemical, chemical composition, antioxidant and antimicrobial screening parameters in leaf of Rhamnus prinoides which are used to impart bitterness to local alcoholic beverages in Ethiopia and as traditional medicine in some African countries. The phytochemical screening of aqueous and methanol/water plant extracts was performed using standard phytochemical techniques for the determination of the presence of alkaloids, steroids, triterpines, tannins, flavanoids, flavones, phenols, glycosides, anthraquinones, proteins and resins. The nutritional value of samples were analyzed for their chemical composition (moisture, proteins, fat, carbohydrates and ash) using AOAC (Association of Analytical chemists procedures. The antimicrobial activities of the plant extracts against Neisseria gonorrhea, Staphylococcus aureus, Escherichia coli, Bacillus cereus, Pseudomonas aeroginosa, and Streptococcus fecalis using broth dilution technique were determined. These were compared with those of benzyl penicillin, oxytetracycline and streptomycin as positive controls in the experiment the extract of Rhamnus prinoides was positive for tannins, triterpenoids, cardiac glycosides, phenolics compounds, saponins and resins. Alkaloids were present in the methanolic/water extract only. The methanolic/water extract of Rhamnus prinoides also shows a broad spectrum of activity against all microorganisms tested except for Neisseria gonorrheae. This shows it has a high content of protein and fiber and is low in fat. The qualities demonstrate that it is this good alternative to other food stuffs and these results serve as the basis of further scientific study into various ways of enhancing the livelihood of particular areas of northern Mekelle through increased Rhamnus prinoides domestication as well as assessing the possible bioactivity of rhamnus against certain human diseases.
The absence of wasting in thymectomized germfree (axenic) mice (1965)

SummaryNeonatally thymectomized mice develop a characteristic wasting disease from 4 weeks to 4 months after thymectomy; no pathogenic bacteria have been isolated from these animals that can be obviously incriminated as the cause of the syndrome. Germ-free: thymectomized mice exhibit none of the symptoms of this disease in 8 months, the maximum period of observation to date.Upon contamination the ex-germfree mice, thymectomized at birth, develop the disease within 4-8 weeks, though those thymectomized at 44-51 days do not develop the disease upon contamination and subsequent conventionalization.
Reliability and risk analysis using artificial neural networks (1995)

This paper discusses preliminary research at Sandia National Laboratories into the application of artificial neural networks for reliability and risk analysis. The goal of this effort is to develop a reliability based methodology that captures the complex relationship between uncertainty in material properties and manufacturing processes and the resulting uncertainty in life prediction estimates. The inputs to the neural network model are probability density functions describing system characteristics and the output is a statistical description of system performance. The most recent application of this methodology involves the comparison of various low-residue, lead-free soldering processes with the desire to minimize the associated waste streams with no reduction in product reliability. Model inputs include statistical descriptions of various material properties such as the coefficients of thermal expansion of solder and substrate. Consideration is also given to stochastic variation in the operational environment to which the electronic components might be exposed. Model output includes a probabilistic characterization of the fatigue life of the surface mounted component.
Research of Knowledge-based Method to Simulation Model Validation (2009)

Aiming at the situation of lacking of reference data in simulation model validation process,a knowledge-based method was proposed.First the system behavior was divided into segments according to behavior patterns.Then behavior features would be extracted.After that,compared features extracted with expert knowledge in the knowledge base,simulation model was validated.Experiments show that the method can solve the problem of lacking of reference data in simulation model validation effectively.
Double-guide-wire access through a single 6-F vascular sheath. (1989)

Three techniques are described that employ double-guide-wire access through a single vascular sheath in the common femoral artery. One technique provides arterial side branch protection during balloon angioplasty of stenotic vascular branch points. Another maintains guide wire access within a dilated renal artery while postangioplasty aortography is performed. A third technique achieves superficial femoral artery access during antegrade femoral artery puncture.
TASTY: Interactive Entity Linking As-You-Type (2016)

We introduce TASTY (Tag-as-you-type), a novel text editor for interactive entity linking as part of the writing process. Tasty supports the author of a text with complementary information about the mentioned entities shown in a ‘live’ exploration view. The system is automatically triggered by keystrokes, recognizes mention boundaries and disambiguates the mentioned entities to Wikipedia articles. The author can use seven operators to interact with the editor and refine the results according to his specific intention while writing. Our implementation captures syntactic and semantic context using a robust end-to-end LSTM sequence learner and word embeddings. We demonstrate the applicability of our system in English and German language for encyclopedic or medical text. Tasty is currently being tested in interactive applications for text production, such as scientific research, news editorial, medical anamnesis, help desks and product reviews.
Automatic Generation Control of Jointly-Owned Generating Units (1979)

A set of procedures and algorithms are developed for automatic generation control of generating units that are jointly-owned by two or more utilities. The control performance is examined using the results of simulation tests. Recommendations are given for future work on improved procedures for coordinated economic dispatch involving jointly-owned generating units.
Prediction of stress levels with LSTM and passive mobile sensors (2019)

Stress levels among people rise through the years, and passive sensing data from mobile phones or other ubiquitous devices have started to found its place in applications of mental health observation. With the ultimate goal of creating an automatic human mental health assistant that helps people to have a better mental condition, a step is taken by creating a stress recognition model. In previous works, the researchers have found correlations between sensor data and mental health conditions. They attempted to predict the stress level by different data sources. Due to there is no direct link between any sensor data with mental health, Machine Learning algorithms are employed to uncover relations with multiple sensors and mental well-being. The utilized machine learning algorithms work with non-sequence data hence the researchers need to extract features that represent historical sensor data as one value features. However, extracted features cannot completely represent time-varying sequence data. Within the scope of this study, we demonstrate that LSTM, CNN and CNN-LSTM algorithms, which accept sequence data as input can also work in passive mobile phone sensor data to predict human mental stress. The performance of the model on StudentLife dataset that includes passive mobile sensing data and stress feedbacks of college students has 62.83% accuracy on 460 test instances by training with 800 instances with LSTM model. The diversity of the data is limited and the size is tiny for the data-hungry LSTM model. Consequently, the model could not generalize on adapted features with the small sample size. Although we did not adapt complex features, the results encourage us to improve data size and continue to research on this topic.
Subgroup analyses of a phase III trial comparing tivozanib hydrochloride versus sorafenib as initial targeted therapy for patients (pts) with metastatic renal cell carcinoma (mRCC). (2013)

354 Background: Tivozanib hydrochloride (T) is a potent, selective, tyrosine kinase inhibitor of all 3 VEGF receptors with a long half-life. T has shown tolerability and has extended progression-free survival (PFS) compared with sorafenib (S; median 11.9 months vs. 9.1 months; p =0.042) in a phase III trial (TIVO-1) as initial targeted therapy for pts with mRCC. We report results of PFS subgroup analyses from TIVO-1. Methods: Pts with clear-cell mRCC, prior nephrectomy, and ≤1 prior treatment for mRCC were randomized to T (n=260) or S (n=257). Cox proportional hazards model was used to evaluate PFS. Results: Significant improvement in PFS by T vs. S was observed for the following prespecified subgroups: white, Eastern Cooperative Oncology Group (ECOG) performance status 0, ≥1 year since diagnosis, no prior treatment, ≥2 metastatic sites, North America/Western Europe, baseline systolic blood pressure (SBP) ≤140 mm Hg, and baseline diastolic BP (DBP) ≤90 mm Hg. Exploratory subgroup analysis showed a similar significant improvement by T vs. S in Memorial Sloan-Kettering Cancer Center (MSKCC) favorable prognostic group, and pts who developed hypertension on study had significantly longer PFS than pts with normal BP. The improvement in PFS by T vs S was more marked for the subgroups that developed hypertension (selected subgroups shown in the table). Conclusions: PFS subgroup analyses showed a consistent advantage with T vs. S for mRCC. Clinical trial information: NCT01030783. [Table: see text]
Senile Plaques and Other Senile Changes in the Brain of an Aged American Black Bear (1995)

A female American black bear (Euarctos ursus americanus) over 20 years old had shown epileptiform neurologic signs starting in March 1992 and was found dead unexpectedly 8 months later. At necropsy, pulmonary and intrabronchial hemorrhage was noted. In the brain, the leptomeninges exhibited slight thickening, and petechiae were evident in the hippocampus. Histopathologic examination of the brain revealed several senile changes: numerous senile plaques, amyloid deposition in cerebromeningeal arterioles, mineral deposition in the pallidum, and numerous corpora amylacea in the cerebellum.
Essential role for p38α mitogen-activated protein kinase in placental angiogenesis (2000)

The p38 family of mitogen-activated protein kinases (MAPKs) mediates signaling in response to environmental stresses and inflammatory cytokines, but the requirements for the p38 MAPK pathway in normal mammalian development have not been elucidated. Here, we show that targeted disruption of the p38alpha MAPK gene results in homozygous embryonic lethality because of severe defects in placental development. Although chorioallantoic placentation is initiated appropriately in p38alpha null homozygotes, placental defects are manifest at 10.5 days postcoitum as nearly complete loss of the labyrinth layer and significant reduction of the spongiotrophoblast. In particular, p38alpha mutant placentas display lack of vascularization of the labyrinth layer as well as increased rates of apoptosis, consistent with a defect in placental angiogenesis. Furthermore, p38alpha mutants display abnormal angiogenesis in the embryo proper as well as in the visceral yolk sac. Thus, our results indicate a requirement for p38alpha MAPK in diploid trophoblast development and placental vascularization and suggest a more general role for p38 MAPK signaling in embryonic angiogenesis.
Altered dendritic cells (DC) might be responsible for regulatory T cell imbalance and autoimmunity in nonobese diabetic (NOD) mice. (2002)

Nonobese diabetic (NOD) mice spontaneously develop diabetes, an auto-immune disease characterized by the destruction of insulin-secreting beta-cells by autoreactive T cells. Defects in development and/or functions of dendritic cells (DC) might be critical in eliciting the auto-immune reaction to beta cells in this model. In this paper, DC differentiation in NOD mice was investigated in vitro using bone marrow-derived progenitors (BM-DC) in the presence of GM-CSF and IL-4 or spleen-derived progenitors in the presence of GM-CSF and early acting cytokines such as Flt-3L and IL-6 (SPL-DC). In both culture systems, the absolute number of NOD DC generated was strongly reduced as compared to control strains. In addition, both BM-DC and SPL-DC from NOD mice show defective differentiation into mature DC in conventional culture conditions as indicated by low expression of MHC class II and CD80 molecules among CD11c positive cells and low capacity to stimulate allogeneic T cells. However, DC achieved full maturation when exposed to LPS, except for MHC class II expression that remained decreased. Ex vivo analysis confirmed an unusual phenotype of NOD DC. Both sets of results are thus consistent with a specific defect of DC maturation in these mice.
Low Power Current Mode ADC for CMOS Sensor IC (2005)

Current-mode algorithmic pipelined analog-to-digital converters (ADC) are suitable for sensor applications due to their area and power advantage at low resolutions. In applications of distributed sensing using redundant sensors, the speed and the resolution of the ADC is less important than the energy per bit conversion. Such performance was achieved by using the current-mode technique with transistors operating in the sub-threshold region. Both sub-threshold and current mode techniques allow for low-voltage and low-power operation. An improved current-mode, 6-bit, 125 kHz algorithmic ADC was designed for an integrated sensor in 0.18 /spl mu/m technology. The power consumption of the ADC is under 6 /spl mu/W and less than 8 pJ per bit.
Synthesis, Characterization, and Properties of Phosphoryl Choline Functionalized Poly ε-caprolactone and Charged Phospholipid Analogues (2003)

Here, we introduce the synthesis, characterization, and surface orientation properties of a new generation of biodegradable and biomimetic polymers. These phospholipid-mimetic, biodegradable polymers are synthesized by combining poly ε-caprolactone (PCL) with various functional polar end-groups, including zwitterionic phosphoryl choline (PC), anionic succinic acid, and cationic quaternary ammonium. The polyester backbone provides mechanical stability and biodegradability, whereas the various headgroups provide a variety of functions. The careful evaluation of the synthesis has allowed reaction conditions to be optimized, leading to complete conversion at each step and, subsequently, high yields of PCL−PC. Analysis of the ability for trimethylamine to cause any adverse transesterification reactions has shown that no molecular scrambling occurs either with two low-molecular-weight esters or with PCL. Therefore, the PCL initially present is retained throughout the synthesis. In parallel to the polymer synthesis, a model synthesis was conducted using benzyl 6-hydroxy hexanoate as a starting point, to aid the conversion studies and spectroscopic characterization. We ascertained from this feature that such synthesis allows the formation of any molecular architecture with targeted functionalities. The film properties of the PCL−PC amphiphile product revealed surface enrichment behavior, because the polar PC headgroup is oriented toward the surface. This followed the treatment of a cast film in a hydrophilic environment, as observed by electron spectroscopy for chemical analysis.
An Overview of LiFi: a 5G candidateTechnology (2018)

In this modern era where all the facilities such as banking, shopping, online payments, games etc. all equipment can be accessed by Internet, has led to congestion of radio spectrum. Many solutions have been suggested to solve this issue; one of them is Li-Fi (Light Fidelity). This 5G visible light communication (VLC) system uses light emitting diodes to achieve high data rates in a similar manner as Wi-Fi (Wireless Fidelity). All types of light support Li-Fi data transmission i.e. visible, infrared and ultra-violet. Professor Harald Hass from University of Edinburgh invented Li-Fi. Communication using near Ultraviolet or visible region of electromagnetic spectrum provides better frequency range, productivity, accessibility and safety than Wi-Fi. Li-Fi has already attained extremely faster speed in lab. In this review paper, we have encapsulated the strengths, feebleness, chances and threats of Li-Fi technology. This 5G candidate technology has many strengths, the most indispensable of them all is that it is leveraging the low-cost LEDs which allows people to use the web by LED bulbs available a street corner, the vehicles to interlink with each other through the available headlights.
The Dependence of PGA and PGV on Distance and Magnitude Inferred from Northern California ShakeMap Data (2003)

We analyze peak ground velocity (PGV) and peak ground acceleration (PGA) data from 95 moderate (3.5 ≤ M r > 100 km, the peak motions attenuate more rapidly than a simple power law (that is, r -γ ) can fit. Instead, we use an attenuation function that combines a fixed power law ( r -0.7 ) with a fitted exponential dependence on distance, which is estimated as exp(-0.0063 r ) and exp(-0.0073 r ) for PGV and PGA, respectively, for moderate earthquakes. We regress log(PGV) and log(PGA) as functions of distance and magnitude. We assume that the scaling of log(PGV) and log(PGA) with magnitude can differ for moderate and large earthquakes, but must be continuous. Because the frequencies that carry PGV and PGA can vary with earthquake size for large earthquakes, the regression for large earthquakes incorporates a magnitude dependence in the exponential attenuation function. We fix the scaling break between moderate and large earthquakes at M 5.5; log(PGV) and log(PGA) scale as 1.06M and 1.00M, respectively, for moderate earthquakes and 0.58M and 0.31M for large earthquakes.
Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation. (1989)

A novel class of antibiotics was isolated from cultures of Streptomyces coeruleorubidus strain AB 1183F-64. The antimicrobial activity of the pacidamycins is selective against Pseudomonas aeruginosa. The various congeners are nucleoside peptides which differ in the terminal amino acid residues. The structures were determined using MS-MS and 2D NMR techniques.
Mobile Computing to Facilitate Interaction in Lectures and Meetings (2005)

The Campus Mobile project explored how PDAs and innovative interfaces can improve interaction during lectures and in small meetings. These mobile computers (small PCs or PDAs) are nomad mediators that provide the link between the public space and the user's private space. A lecturer uses an augmented whiteboard to annotate her presentation, while the slides and annotations are broadcast in real time to the students' PDAs. The students can also annotate the presentation. They can then replay the lecture at their leisure. We developed and tested the user interfaces for the interactions on the whiteboard and on the PDAS, the data formats to store the annotations and temporal data, and the network protocol for reliable wireless broadcast transmission. Small meetings have a very different interaction pattern. Instead of a lecturer that transmits knowledge, the participants collaborate in modifying documents. We developed groupware services that encourage these interactions and show how the different interaction patterns imply different network usages.
Sexual behaviour and condom use among individuals with a history of symptomatic genital herpes (2006)

These data indicate that the majority of people with GH either abstained from intercourse or "always" used condoms during symptomatic periods of GH. However, condom use was relatively low during asymptomatic periods in comparison with symptomatic periods. These results highlight that further education on GH prevention is warranted, particularly for symptomatic periods.
Ilse B (2000)

I set out for Ilse B.'s house in Grosse Borstel (western Hamburg) on a chilly Sunday in March. Our meeting was set for 10:00 A.M., but her home was far out and a friend and I got lost after departing from the train. After a few phone calls to Ilse, I figured out the location and arrived at 11:30. A wellpreserved, beautiful, and smiling older woman opened the door. Ilse was tall and thin with fine white hair. She dressed as if ready for church: She wore an exquisite peach cashmere sweater, a wool brown-blue skirt, and carefully chosen jewelry. She was not bothered by the delay, but her nervousness was immediately discernible. It took some time to arrange ourselves in separate chairs. I was conscious of her jewelry the entire interview: the pearl circle pin, green-colored pearls, black onyx ring, green coral bracelet, and a large watch. Her house with its cherry furniture and four Oriental rugs, like herself, exuded expensive taste. Pictures of her two grandchildren, both with dark hair, and four colorful paintings and sketches, one of her daughter, dominated the room. She had numerous animal china pieces—a goose with a blue ribbon and a yellow egg candle, and two dogs—and a collection of thimbles and old books.KeywordsYoung GirlConcentration CampJewish WomanJewish PeopleMixed MarriageThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.