gebhart/patrepeval huggingface dataset:
Educational Technology and the Future (1981)

The computer, and such associated devices as the optical videodisc, is at present little used in the learning process. But this use is extremely likely to increase rapidly in the future. There will be important implications to those interested in learning. The present paper outlines some of those implications.
High-speed ultrasonic digital delay line design: A restatement of some basic considerations (1968)

In the past, ultrasonic delay lines in digital storage applications tended to be designed for a maximum storage capacity compatible with losses in the delay medium in order to minimize the cost of access circuitry. This approach yielded capacities upward of 20 000 bits per delay line but necessitated complicated arrangements to fold up the relatively long delay path in an acceptable space. It also required delay materials with a low ultrasonic propagation loss and accurate temperature stabilization, and resulted in comparatively long average access times to a given bit of information in the store. The emergence of inexpensive access and retiming circuits, however, suggests that delay line stores may be made at lower expense by subdividing them into modules of smaller capacity, and regenerating and retiming the bit stream it each module. This approach leads to design considerations different from the previous approaches and causes requirements of mechanical precision and temperature stability to be lowered. The design procedure described predicts that with presently available materials delay lines can be built which store about 1000 bits at bit rates in excess of 100 MHz, with insertion losses at band center of less than 20 dB and spurious signal suppression of at least 20 dB. Such lines have a storage density of more than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> bits per inch <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> .
Synthese eines vierfach aufgeweiteten Porphyrins mit extrem hohem, diamagnetischem Ringstromeffekt (1986)

Ein Molekül der Superlative ist das [26]Porphyrin 1 · 2CF3COO⊖. Formal entsteht es durch Einschieben von vier Vinyleinheiten in den Porphyrinring. Die Differenz der δ-Werte der inneren und äußeren Protonen steigt bei 1 · 2CF3COO⊖ auf den enormen Wert von 25.3 ppm! Zum Vergleich: Bei [18]Annulen sind es 12.1 ppm. Bemerkenswert sind auch der extrem große ε-Wert von über 900000 und die “biomimetische” Synthese aus einem Monopyrrol.
Selection of template initiation sites and the lengths of RNA primers synthesized by DNA primase are strongly affected by its organization in a multiprotein DNA polymerase alpha complex (1986)

Synthesis of (p)ppRNA-DNA chains by purified HeLa cell DNA primase-DNA polymerase alpha (pol alpha-primase) was compared with those synthesized by a multiprotein form of DNA polymerase alpha (pol alpha 2) using unique single-stranded DNA templates containing the origin of replication for simian virus 40 (SV40) DNA. The nucleotide locations of 33 initiation sites were identified by mapping G*pppN-RNA-DNA chains and identifying their 5'-terminal ribonucleotide. Pol alpha 2 strongly preferred initiation sites that began with ATP rather than GTP, thus frequently preferring different initiation sites than pol alpha-primase, depending on the template examined. The initiation sites selected in vitro, however, did not correspond to the sites used during SV40 DNA replication in vivo. Pol alpha 2 had the greatest effect on RNA primer size, typically synthesizing primers 1-5 nucleotides long, while pol alpha-primase synthesized primers 6-8 nucleotides long. These differences were observed even at individual initiation sites. Thus, the multiprotein form of DNA primase-DNA polymerase alpha affects selection of initiation sites, the frequency at which the sites are chosen, and length of RNA primers.
[A new index of acceleration plethysmogram and its clinical physiological evaluation]. (1994)

The purposes of the present study were to examine a new index of acceleratingly plethysmogram (APG) and to discuss the possibility to apply the APG index. One hundred sixty-three subjects voluntarily participated in the present study. The mean values (n = 10) of individual coefficient of variance were 7.22% in wave height B, 8.26% in the total area of the lower part under the base line, and 7.28% in a new APG index. The coefficient of variance in the APG index calculated from the previous method (18.67%) was larger than that of the present study. We recognized the significantly polynomial relationship between the new APG index and types of APG. Further, the value of new APG index remarkably increased when the index was beyond 50. There were significant differences in age, blood pressure, rate of body fat, blood glucose, total cholesterol, HDL cholesterol, and index of arteriosclerosis between above 50 and below 50 in the new APG index. These results suggest that the present APG index is adequate about about the individual reproducibility, and it has the possibility to apply as an index of arteriosclerosis.
A review of experimental transverse Doppler studies (1994)

The possibility of detecting useful Doppler information when the ultrasound beam is transversely oriented to the flow, has so far been studied by several authors. A new theory, in particular, has demonstrated that the focusing properties of piezoelectric transducers involve a Doppler signal bandwidth proportional to the transverse velocity component. The key element to perform reliable "transverse" Doppler experimental studies is thus an efficient spectrum analyzer, capable of performing accurate and repeatable bandwidth measurements. The authors review here experimental tests of the new theory, independently done in several laboratories by means of a specially developed computerized spectrum analyzer. The results of these tests include the demonstration that the "transverse" Doppler bandwidth is invariant with the range of cell depth and dimensions. It is also discussed how the basic transverse Doppler technique can be conveniently extended to allow the two- and three-dimensional estimation of the flow vector. Experimental evidence about the possibility of using the new theory to give a correct interpretation of in vivo transverse spectrograms is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New developments in project scheduling (1992)

Examines project scheduling advances in the framework of a job shop or order driven work environment in which an engineered product is manufactured. Argues that scheduling is an important part of the project management process. Reviews some of the antiquated ideas that still remain in project management. Outlines some developments in computer‐based scheduling, management techniques, and the future significance of artificial intelligence.
Electrochemical Modifications of Proteins. 1. Glycitolation (1999)

When an electrochemical method is tentatively applied for N-alkylation of proteins, some Maillard reactions occur on the counter electrode. A low level of reductive N-alkylation of casein was obtained on a cathodic electrode, but the method unfortunately remains poorly efficacious in comparison with those using a hydride donor such as sodium cyanoborohydride. Electroassisted reductive N-alkylation is suitable only for basic proteins such as histones or lysozyme. For other proteins, an alternative consists of either methylating carboxylic residues to increase the value of their isoelectric pH or coating them with a cationic detergent.
Prokaryotic Ubiquitin-Like Protein Provides a Two-Part Degron to<i>Mycobacterium</i>Proteasome Substrates (2010)

Prokaryotic ubiquitin-like protein (Pup) is a posttranslational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino terminus of Pup is required for degradation, while the helical carboxyl terminus mediates its attachment to proteins. Thus, Pup has distinct regions that either interact with pupylation enzymes or initiate proteasomal degradation.
Differentiation of Human Dermal Fibroblasts and Applications in Tissue Engineering (2010)

Tissue engineering applies principles of biology and engineering to the development of functional substitutes for damaged or lost tissues. Tools for the neo-generation of tissue in tissue engineering research include cells, biomaterials and soluble factors. One main obstacle in tissue engineering is the limited availability of autologous tissue specific progenitor cells. This has led to interest into using autologous cells with stem cell plasticity. Bone marrow derived stem cells were the first adult stem cells shown to have multilineage potential. Since, several reports have been published indicating that cells from other tissues; fat, muscle, connective tissue e.g., possess potential to differentiate into lineages distinct from their tissue of origin. The optimal cell type for use in tissue engineering applications should be easy to obtain, cultivate and store. The human dermal fibroblast is an easily accessible cell source, which after routine cell expansion gives a substantial cell yield from a small skin biopsy. Hence, the dermal fibroblast could be a suitable cell source for tissue engineering applications.The main aim of this thesis was to investigate the differentiation capacity of human dermal fibroblasts, and their possible applications in bone and cartilage tissue engineering applications. Human dermal fibroblasts were shown to differentiate towards adipogenic, chondrogenic, and osteogenic phenotypes upon subjection to specific induction media. Differentiation was seen both in unrefined primary cultures and in clonal populations (paper I). Fibroblasts could be used to create three-dimensional cartilage- and bone like tissue when grown in vitro on gelatin microcarriers in combination with platelet rich plasma (paper II). 4 weeks after in vivo implantation of osteogenic induced fibroblasts into a fracture model in athymic rats, dense cell clusters and viable human cells were found in the gaps, but no visible healing of defects as determined by CT-scanning (paper III). After the induction towards adipogenic, chondrogenic, endotheliogenic and osteogenic lineages, gene expression analysis by microarray and quantitative real-time-PCR found several master regulatory genes important for lineage commitment, as well as phenotypically relevant genes regulated as compared to reference cultures (paper IV). In conclusion, results obtained in this thesis suggest an inherent ability for controllable phenotype alteration of human dermal fibroblasts in vitro. We conclude that dermal fibroblasts could be induced towards adipogenic, chondrogenic, endotheliogenic or osteogenic novel phenotypes which suggest a genetic readiness of differentiated fibroblasts for lineage-specific biological functionality, indicating that human dermal fibroblasts might be a suitable cell source in tissue engineering applications.
Gamma interferon stimulates monocyte chemotactic protein (MCP-1) in human mesangial cells. (1994)

Cell-mediated immunity and monocyte infiltration is a prominent histologic feature of several different types of glomerulonephritis. Monocyte influx to the glomerulus correlates with glomerular hypercellularity and proteinuria. Glomerular mesangial cells, in addition to being targets for inflammatory stimuli, are also effector cells that actively participate in glomerular pathology. Mesangial cells release monocyte chemotactic protein (MCP-1). In the present article, we characterized and studied the regulation of MCP-1 released by cultured human mesangial cells. Serum-deprived mesangial cells constitutively release chemotactic activity that is neutralized by specific anti-MCP-1 antibody. An antibody to baboon MCP-1 recognized 16, 15, and 11 kd proteins from concentrated conditioned medium that were consistent with the presence of different forms of MCP-1. Gamma interferon (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 (IL-1) markedly stimulate the release of MCP-1 as measured by a specific and sensitive radioimmunoassay. The release of MCP-1 in response to these cytokines is at least partially dependent on de novo synthesis of the protein because all three cytokines markedly stimulate the expression of MCP-1 mRNA. These data demonstrate that human mesangial cells synthesize and release at least three different forms of MCP-1 and that IFN-gamma and other cytokines regulate the secretion of MCP-1. IFN-gamma and MCP-1 may play a major role in the recruitment and activation of monocytes to the inflamed glomerulus.
Synthesis of new codeinone and indolinocodeinone derivatives (1971)

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy at Loughborough University.
The mechanism and effective connecting architecture for tandem organic light-emitting devices (2005)

The concept of tandem organic light-emitting devices (OLEDs) provides a pathway for developing highly stable and efficient OLEDs. The connecting structure that bridges adjacent light-emitting units, substantially affects the device performance of tandem OLEDs. In this letter, we introduce an effective connecting structure in which an ultrathin middle metal layer is sandwiched between efficient electron- and hole-injection layers for the tandem OLEDs, which in essence, avoids the use of reactive metals during fabrication. Two-unit tandem OLEDs with such connecting structure exhibit less than double the driving voltage, yet more than double the efficiency, more saturated emission color, and longer operational lifetime compared to those of single-unit devices. A model based on a hypothesis of energy level pinning effect has been proposed as the mechanism of the connecting structure in the tandem devices. This model is also consistent with the results obtained from the photovoltaic effect measurements in tandem OLEDs.
[Effects of estradiol intervention on peripheral blood CD90+ cells and cardiac function in de-ovary rats before and after myocardial infarction]. (2006)

Replacement with estradiol before myocardial infarction exerts more beneficial effects than estradiol replacement after myocardial infarction in de-ovary rats.
Purine Nucleoside Phosphorylase from <i>Escherichia coli</i> and <i>Salmonella typhimurium</i> (1975)

The purine nucleoside phosphorylases from Escherichia coli and from Salmonella typhimurium have been purified to electrophoretic homogeneity and crystallized. Comparative studies revealed that the two enzymes are very much alike. They obey simple Michaelis-Menten kinetics for their substrates with the exception of phosphate for which they show negative cooperativity. Gel filtration on Sephadex G-200 of the native enzymes revealed a molecular weight for both enzymes of 138000 plus or minus 10%. By use of dodecylsulphate gel electrophoresis a subunit molecular weight of 23700 plus or minus 5% was determined, suggesting that both enzymes consist of six subunits of equal molecular weight. When the subunits were partially crosslinked with dimethyl suberimidate before dodecylsulphate electrophoresis six protein bands were observed in agreement with the proposed oligomeric state of the enzyme, consisting of six subunits of equal molecular weight. Analysis of the amino acid composition also indicates that the subunits are identical. 6M guanidinium chloride dissociates the enzymes; association experiments with native and succinylated enzymes suggested that only the hexameric form is active. Both enzymes could be dissociated into subunits by p-chloromercuribenzoate; this dissociation is prevented by the substrates: the nucleosides, the pentose 1-phosphates, and mixtures of phosphate and purine bases.
Steerable interactive television: virtual reality technology changes user interfaces of viewers and of program producers (2001)

Television has traditionally been a passive medium from the viewer's perspective. The viewer sits in front of the television receiver and passively absorbs what is presented. On the other hand immersive virtual reality systems engage the user and bring the user into the virtual world, often as a participant rather than just as an observer. This paper looks at applying virtual reality display technology, the Address Recalculation Pipeline, to the familiar technology of television. In so doing it transforms the relationship between the viewers and the television program producers. It can be made compatible with conventional television for those without the means or inclination to buy the new technology, and provides a base for future developments in virtual reality to be brought to the mass market. Linking virtual reality technology to mass entertainment has the potential to stimulate consumer interest and hence research and development funding in this demanding area, as well as providing an exciting, interactive system in its own right. The user interfaces of both the television production team and of the viewer are changed dramatically with this technology. This paper outlines how the user interfaces differ from conventional ones. An overview of the virtual reality display technology is given to set the scene.
Shadow Doppler technique for sizing particles of arbitrary shape (1994)

The output from a linear diode array is used in a modified laser Doppler velocimeter to measure the size and shape of irregular particles. The sizing accuracy for transparent and opaque particles between 30 and 140 µm is better than 10%. The inaccuracy caused by trajectories that lay at angles of less than 24° to the axis of the array was less than +5%, and a further inaccuracy of +5% was caused by defocusing of the particle from the center of the velocimeter measuring volume by up to ±500 µm. The advantages of the shadow Doppler technique over other techniques for sizing irregular particles, such as amplitude systems with pointer volumes, are that the shadow Doppler technique records shape, the optical arrangement is more robust, less precise alignment is required, and the equipment can be constructed at low cost.
Social login with OAuth for mobile applications: User's view (2016)

Social network credentials can be used to login to native applications installed in smartphones or tablet computers. This approach is known as social login (SL) where its implementation is carried out using OAuth protocol. Communication between applications and social network servers involves with browser redirection. Applications could redirect token to any URL including malicious applications that intend to steal users' credential. This issue can be improved by developing a built-in module that handles the authorization process. An approach known as OAuth Manager Module is presented in this paper. A prototype application was developed to demonstrate the approach. Facebook SL was also provided as the authentication mechanism. The prototype is evaluated through a controlled experimentation of real users. The users interacted with the prototype and gave their views on the security of the module. The security of the module is compared with the common mobile browser implementation. The result suggests that users see that communication using the module is more secure than the mobile browsers.
Protein partitioning in two-phase aqueous nonionic micellar solutions (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProtein partitioning in two-phase aqueous nonionic micellar solutionsY. J. Nikas, C. L. Liu, T. Srivastava, N. L. Abbott, and D. BlankschteinCite this: Macromolecules 1992, 25, 18, 4797–4806Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/ma00044a048https://doi.org/10.1021/ma00044a048research-articleACS PublicationsRequest reuse permissionsArticle Views387Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Toward discovery support systems: A replication, re-examination, and extension of Swanson's work on literature-based discovery of a connection between Raynaud's and fish oil (1996)

Don R. Swanson has undertaken a program of research to use the published medical literature as a source of discoveries. We have attempted to replicate his discovery of a connection between Raynaud's disease and dietary fish oil, as well as develop computer-based searching methods that could usefully support literature-based discoveries. We have been successful in replicating Swanson's discovery and have developed a method of discovery support based on the complete text of MEDLINE records. From these, we compute statistics based both on the frequency of tokens within a literature and on the number of records containing various tokens. We discuss the use of these statistics, suggesting that token and record frequencies are good indicators of literatures profitably related to some source literature, and that relative record frequencies are useful in isolating literatures with the potential of containing a discovery. © 1996 John Wiley & Sons, Inc.
Surface Stress Curves for Gold (1976)

Changes in surface stress of gold ribbon electrodes as a function of potential were measured in various electrolytes with an extensometer instrument. Electrocapillary‐type curves were obtained for which the change in surface stress can be equated to change in surface tension. As for mercury, the potential of the surface stress maximum for gold is independent of pH. The observed anion adsorption order on gold Was , ,. Experimental surface stress data and charge passed gave approximate agreement with the Lippmann equation in the electric double layer regions Formation of oxide film significantly lowered the surface stress.