gebhart/patrepeval huggingface dataset:
Protective effects of IL-4 and IL-10 against immune complex-induced lung injury. (1993)

Recombinant murine IL-4 and IL-10 have been used in two models of inflammatory lung injury in rats after intrapulmonary deposition of IgG or IgA immune complexes. These models have contrasting requirements for cytokines, phagocytic cells, and adhesion molecules. In these two models of lung injury, IL-4 and IL-10 were individually coinstilled into the airways with the IgG or IgA antibodies, whereas the Ag were injected intravenously. Injury was quantitated by increases in permeability (leakage of 125I-BSA) and by hemorrhage (extravasation of 51Cr-RBC). In the model of IgG immune complex-induced lung injury, IL-4 and IL-10 were each highly protective when given in nanogram amounts. These protective effects were dose dependent. IL-4 and IL-10 caused substantial reductions in lung content of myeloperoxidase and parallel reductions in neutrophil content in bronchoalveolar lavage (BAL) fluids. The protective effects of IL-4 and IL-10 were associated with profound reductions of TNF-alpha in the BAL fluids and complete inhibition in the up-regulation of pulmonary vascular ICAM-1. In the IgA immune complex model of lung injury IL-4 had no protective effects, whereas IL-10 was highly protective. These protective effects correlated with diminished retrieval of alveolar macrophages in BAL fluids. These data suggest that IL-4 and IL-10 have significant protective effects in lung inflammatory injury, presumably achieving these effects by various mechanisms.
On the doubly-linked list protocol for distributed shared memory multiprocessor systems (2002)

This paper introduces the doubly-linked list (DLL) protocol for distributed shared memory (DSM) multiprocessor systems. The protocol makes use of two linked lists to keep track of valid copies of pages in the system, thus eliminating the use of copysets. Simulation studies show that the DLL protocol achieved considerable speed-up for common mathematical problems including a linear equations solver and a matrix multiplier. Performance improvement of up to 51.9% over the dynamic distributed manager algorithm is obtained. Further improvement and possible modification of the protocol are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel Hinge‐Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure–Activity Relationship Study on Tofacitinib Bioisosteres (2014)

The Janus kinases (JAKs) are a family of cytosolic tyrosine kinases crucially involved in cytokine signaling. JAKs have been demonstrated to be valid targets in the treatment of inflammatory and myeloproliferative disorders, and two inhibitors, tofacitinib and ruxolitinib, recently received their marketing authorization. Despite this success, selectivity within the JAK family remains a major issue. Both approved compounds share a common 7H-pyrrolo[2,3-d]pyrimidine hinge binding motif, and little is known about modifications tolerated at this heterocyclic core. In the current study, a library of tofacitinib bioisosteres was prepared and tested against JAK3. The compounds possessed the tofacitinib piperidinyl side chain, whereas the hinge binding motif was replaced by a variety of heterocycles mimicking its pharmacophore. In view of the promising expectations obtained from molecular modeling, most of the compounds proved to be poorly active. However, strategies for restoring activity within this series of novel chemotypes were discovered and crucial structure-activity relationships were deduced. The compounds presented may serve as starting point for developing novel JAK inhibitors and as a valuable training set for in silico models.
One-step neural network inversion with PDF learning and emulation (2006)

We present two new types of neural networks (both of which can be trained with ordinary error backpropagation) and we present a new algorithm for learning a probability density function (pdf) from example vectors. It is normally difficult to invert a neural network, but for the new bijective neural network, it is efficient to find an input producing any desired output, and such an input is guaranteed to exist and to be unique. Furthermore, it can be used as one component in building a pdf neural network, which is a neural network with a nonnegative output, and for which it is guaranteed that the integral of the output is exactly 1.0 (as in a pdf function). Both of these can be used for supervised learning using standard error backpropagation. Finally, the new pdf learning algorithm is capable of using those networks to learn a pdf given i.i.d. samples drawn from that pdf, and to then generate new vectors from the learned pdf. This, in turn, allows inversion of a function with non-unique inverses, where each inverse is generated with just a single evaluation of the network.
IL-2-secreting recombinant bacillus Calmette Guerin can overcome a Type 2 immune response and corticosteroid-induced immunosuppression to elicit a Type 1 immune response (2002)

The efficacy of bacillus Calmette Guerin (BCG) as a vaccine against tuberculosis is adversely affected by both genetic and environmental factors on the immune system. In this study we have demonstrated that a recombinant BCG (rBCG) secreting biologically active IL-2 has the ability to induce a T(h)1 profile in both immunocompromised and in IL-4 transgenic (Tg) mice. Dexamethasone (DXM) was administered orally to mice prior to vaccination with either rBCG or normal BCG (nBCG). Six weeks post-vaccination with rBCG, splenocytes from DXM-treated mice exhibited a strong antigen-specific proliferative response, while also secreting large amounts of IFN-gamma and low levels of IgG1. The opposite profile occurred when DXM-treated mice were vaccinated with nBCG. Splenocytes from these mice showed no significant proliferation and produced a cytokine profile associated with a T(h)2 immune response, in addition to exhibiting high levels of serum IgG1. In the IL-4 Tg model, mice vaccinated with rBCG again produced a strong T(h)1 immune response, exhibiting a high antigen-specific IFN-gamma:IL-4 ratio and a concomitantly high IgG2a:IgG1 ratio. IL-4 Tg mice vaccinated with nBCG produced the opposite profile. These findings suggest that BCG can be made more robust by incorporating immunopotentiating cytokines into the vaccine.
The formation and characterization of electrical contacts (Schottky and Ohmic) on gallium nitride nanowires (2008)

The authors acknowledge that the content of this paper is closely related to that of a previous publication, by two of the same authors, which was not cited in their later publication. They agree that their statement '... little work has been reported on nanoscale Ohmic and Schottky contacts to 1D semiconductor nanowires [12, 14]' should also have included the following citation to the work that they had themselves reported:
New Phosphine Oxides as High Performance Near- UV Type I Photoinitiators of Radical Polymerization (2020)

Carbazole structures are of high interest in photopolymerization due to their enhanced light absorption properties in the near-UV or even visible ranges. Therefore, type I photoinitiators combining the carbazole chromophore to the well-established phosphine-oxides were proposed and studied in this article. The aim of this article was to propose type I photoinitiators that can be more reactive than benchmark phosphine oxides, which are among the more reactive type I photoinitiators for a UV or near-UV light emitting diodes (LED) irradiation. Two molecules were synthesized and their UV-visible light absorption properties as well as the quantum yields of photolysis and photopolymerization performances were measured. Remarkably, the associated absorption was enhanced in the 350-410 nm range compared to benchmark phosphine oxides, and one compound was found to be more reactive in photopolymerization than the commercial photoinitiator TPO-L for an irradiation at 395 nm.
A tunneling approach to routing with unidirectional links in mobile ad-hoc networks (2002)

Mobile ad hoc networks (MANETs) consist of a set of similar mobile nodes, communicating with each other using wireless links. As a node may not be able to directly reach every other node, a packet may need to traverse multiple wireless links from its source to its destination. Unidirectional links can occur in such networks. Several existing routing protocols implicitly assume bidirectional links when making their routing decisions. Not using unidirectional links can lead to sub-optimal routes. A tunneling solution to allow efficient operation in ad hoc networks with unidirectional links is presented. The tunneling solution uses information gathered by the routing protocol to tunnel packets from the end-point of the unidirectional link to its source. A naive implementation of tunneling could lead to loops in the system and a deluge of packets. This is because when ACKs (acknowledgments) for link layer messages are tunneled across unidirectional links, ACKs for them may end up being generated recursively. The solution presented here prevents such a packet explosion from occurring.
Planarized Triarylboranes: Stabilization by Structural Constraint and Their Plane-to-Bowl Conversion (2012)

Triphenylborane and 9,10-diphenyl-9,10-dihydro-9,10-diboraanthracene, constrained to a planar arrangement with methylene tethers, were synthesized by intramolecular multi-fold Friedel-Crafts cyclization. These compounds were stable toward air, water, and amines, despite the absence of steric protection in the vertical direction with respect to the B atoms, and showed characteristic structural, electronic, and photophysical properties. In addition, upon treatment with a fluoride ion, these compounds underwent a plane-to-bowl conversion in a controlled manner.
A Study of Exploration of Heterogeneous Personal Data Collected from Mobile Devices and Web Services (2011)

This paper presents a study on the exploration of heterogeneous personal data that are collected from daily life. Most life log research has focused on the capture of personal logs and personal data archives. Although large amounts of personal data can be collected, it is not easy to find effective methods of reusing these data. Our research focuses on helping users recall and reminisce past events with an interactive system that enables them to explore personal data from several viewpoints. These viewpoints and corresponding views are described with a zooming user interface. We also illustrate a summary of personal data and landmarks that trigger memory recall. These concepts and user interfaces are implemented in a prototype system designed for exploring a variety of personal data including photographs, GPS histories, Tweets, and the number of steps people walk.
Limited value of serum holo-transcobalamin II measurements in the differential diagnosis of macrocytosis. (1996)

Measurements of serum holo-TCII concentrations by the silica adsorption method are not of value in the differential diagnosis of macrocytosis. The finding of low serum holo-TCII concentrations in patients with macrocytosis due to causes other than Cb1 deficiency may result not only from a state of negative Cb1 balance but also from other factors, such as increased utilisation of holo-TCII as a consequence of erythroid hyperplasia.
A Systematic Review of Scales That Measure Attitudes Toward Suicide (2010)

Each of these scales has its own characteristics and should be used in accordance with research purposes.
Agents for the Grid: A Comparison with Web Services (part II: Service Discovery) (2002)

In order to build an open, large-scale and inter-operable multi-agent system in the context of Grid computing, we are looking at integrating agents technologies with Web Services. In this paper, we address this concern for SoFAR, the Southampton Framework for Agent Research. We focus on all technical aspects of creating, deploying, and publishing agents as Web Services. Not only have we been able to translate SoFAR ontologies and agent behavioural descriptions respectively into XML Schemas and WSDL, but also we have reexpressed in terms of XML Schema validation a pattern matching oriented query language used in discovery mechanism. Using this approach, an agent in the SoFAR framework can be deployed and advertised through a standard discovery mechanism such as UDDI.
Adaptive multimedia streaming over IP based on customer oriented metrics (2006)

Delivering multimedia services over IP is expected to represent a significant contribution to final revenues of most telcos and content producers. This new paradigm of customer-made, on-demand services calls for new approaches to the whole life cycle service management. In this article an analytical method to determine the delivered quality of experience is presented. It does so from an end-user point of view for it helps network operators to better fulfil their customer's expectations. Being an analytical approach, it explicitly states the existing relationship of delivered quality and observable network metrics thus enabling solid service management procedures
Phosphonylation of a polypentenamer and preparation of its hydrogenated derivatives (1977)

Abstract Phosphonylated derivatives of a polypentenamer (PP) containing 82% trans and 17% cis double bonds have been prepared by the free‐radical addition of dimethylphosphite to the double bonds and subsequent hydrogenation of the residual unsaturation. In this way derivatives were prepared containing approximately 5 and 10 mole % dimethylphosphonate side groups. These side groups were further reacted by hydrolysis or neutralization to form phosphonic acid and cesium phosphonate salts. Reaction conditions were so chosen that no backbone degradation occurred, and side reactions leading to crosslinking were avoided. The derivatives were characterized by gel‐permeation chromatography (GPC), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), infrared spectroscopy, and nuclear magnetic resonance spectroscopy. It was found that increasing substituent concentration decreases the melting point T m in the case of the hydrogenated derivatives and increases the glass transition temperature T g in the case of the unhydrogenated derivatives. The free acid derivatives are the least thermally stable of all those studied and the hydrogenated derivatives are generally more stable than the unhydrogenated derivatives.
New reflow soldering and tip in buried box (TB2) techniques for ultrafine pitch megapixels imaging array (2008)

Flip chip is a high-density and highly reliable interconnection technology which is mandatory for the fabrication of high end heterogeneous imaging arrays. The control of ultra-fine pitch (<10 mum) and high bumps count flip-chip bonding technology represents a challenge on the roadmap of next generation devices (Kozlowski). This paper describes and compares in details two new flip- chip technologies that can address the challenges at the 10 mum pitch node: a modified reflow soldering technology and a thermocompression "tip in buried box" (TB2) insertion technology. The technological preparation of the flip-chipped devices is fully described including new maskless underbump metallization (UBM) technique, new maskless soft solder buried box filling technique and new "micro-tube" fabrication technique. First the flip chip experiments are described as well as two methods to evaluate minimum insertion force for the TB2 technology: 500times500 area arrays insertion/ pull out forces are measured as well as original "single tip into solder" insertion/ pull out forces. The reduction of the required thermocompression forces obtained with "micro-tube" is demonstrated, finally first reflow and thermocompression hybridization results are achieved and commented.
Benes switching fabrics with O(N)-complexity internal backpressure (2005)

Multistage buffered switching fabrics are the most efficient method for scaling packet switches to very large numbers of ports. The Benes network is the lowest-cost switching fabric known to yield operation free of internal blocking. Backpressure inside a switching fabric can limit the use of expensive off-chip buffer memory to just virtual-output queues in front of the input stage. This article extends the known credit-based flow control (backpressure) architectures to the Benes network. To achieve this, we had to successfully combine per-flow backpressure, multipath routing (inverse multiplexing), and cell resequencing. We present a flow merging scheme that is needed to bring the cost of backpressure down to O(N) per switching element, and for which we have proved freedom from deadlock for a wide class of multipath cell distribution algorithms. Using a cell-time-accurate simulator, we verify operation free of internal blocking, evaluate various cell distribution and resequencing methods, compare performance to that of ideal output queuing, the iSLIP crossbar scheduling algorithm, and adaptive and randomized routing, and show that the delay of well-behaved flows remains unaffected by the presence of congested traffic to oversubscribed output ports.
Simple Disk-Based Method for Detection of <i>Klebsiella pneumoniae</i> Carbapenemase-Type β-Lactamase by Use of a Boronic Acid Compound (2008)

A disk potentiation method using carbapenems as substrates and 3-aminophenyl boronic acid as an inhibitor was evaluated for the detection of Klebsiella pneumoniae carbapenemase (KPC)-type beta-lactamases. When combined with nonsusceptibility to ertapenem, the method was easy to perform and reliably differentiated isolates producing KPC-type beta-lactamases from those producing other types of beta-lactamases.
A graph-theoretic approach for register file based synthesis (2002)

With the increasing use of register files as storage elements in integrated circuits, the problem of assigning data variables to ports of register files has assumed significance. The assignment involves simultaneous optimization of several cost functions, namely, number of register files, number of registers and access ports per register file, and the interconnect both internal and external to memories. In this paper, we refer to multiplexers, busses, and tristate switches when we refer to interconnect. The objective of this paper is to describe graph-theoretic optimization algorithms for the assignment problem. The allocation system described in this paper (SOUPS) accepts a scheduled data flow graph as input and performs (i) assignment of variables to a minimal number of resisters, (ii) assignments of registers to a minimal number of register files, (iii) assignment of registers to ports of the register files using minimal interconnect within the register files, and (iv) assignment of ports of the register files to terminals of functional modules using minimal interconnect outside the register files. We describe experimental results on several benchmark problems.
Square (2009)

Other| November 01 2009 Square Rich Heller Rich Heller Search for other works by this author on: This Site Google the minnesota review (2009) 2010 (73-74): 7–8. https://doi.org/10.1215/00265667-2010-73-74-7 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Rich Heller; Square. the minnesota review 1 November 2009; 2010 (73-74): 7–8. doi: https://doi.org/10.1215/00265667-2010-73-74-7 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll Journalsthe minnesota review Search Advanced Search The text of this article is only available as a PDF. © 2009 the minnesota review2009 Article PDF first page preview Close Modal Issue Section: Poetry/Fiction You do not currently have access to this content.
Distributed MEMS: new challenges for computation (1997)

How do you program a cloud of dust? That is just one computational challenge posed by MEMS, a technology in which multitudes of interacting tiny machines can add computational behavior to materials and the environment in an embedded, massively distributed fashion. Microelectromechanical systems, or MEMS, are an emerging set of technologies that make it possible to miniaturize and mass produce large numbers of integrated sensors, actuators, and computers. By merging sensing and actuation with computation and communication, MEMS devices can be distributed throughout the environment, coated on surfaces, or embedded within everyday objects to create distributed systems for sensing, reasoning about, and responding to events in the physical world on a scale never before possible. Distributed MEMS applications go well beyond the scaling limits of today's computational paradigms, posing serious challenges and new opportunities for information technology. MEMS will draw on and drive computation in four key areas: (1) control of large numbers of distributed MEMS sensors and actuators; (2) distributed intelligence, raising the general intelligence and capability of machines and matter; (3) MEMS devices as computational elements; (4) multiple energy domain simulation, analysis, and design. We look briefly at only the first of these areas: the problems and opportunities created by the control of large numbers (thousands to millions) of MEMS sensors and actuators, including coupling to the physical world and environment driven event time demands on computation.
TEACHING PICTURE‐NAMING BY MEANS OF BEHAVIOURAL TECHNIQUES: a study of a mildly handicapped boy with a severe perceptual problem (1982)

Summary The behavioural modification procedures of prompting, modelling and reinforcement were used to teach picture‐naming to a mildly mentally handicapped boy with a severe perceptual problem. Following five 40‐ minute teaching sessions on consecutive weekdays he performed significantly better on naming not only line drawings used during the teaching sessions but also line drawings which were not used, and line drawings from the Peabody Picture Vocabulary Test. Stimulus generalisation and response generalisation are discussed. The role of such teaching interventions in improving children's intelligence is considered.
Effects of Nicotinic Acid on Serum and Tissue Cholesterol in Rabbits (1957)

Studies reported in this communication showed that under the experimental conditions, nicotinic acid partially prevented a rise in serum cholesterol but effectively prevented cholesterol deposition in the aorta and, to a lesser extent, cholesterol storage in the liver.
Observation of four-wave mixing in slow-light silicon photonic crystal waveguides (2010)

Four-wave mixing is observed in a silicon W1 photonic crystal waveguide. The dispersion dependence of the idler conversion efficiency is measured and shown to be enhanced at wavelengths exhibiting slow group velocities. A 12-dB increase in the conversion efficiency is observed. Concurrently, a decrease in the conversion bandwidth is observed due to the increase in group velocity dispersion in the slow-light regime. The experimentally observed conversion efficiencies agree with the numerically modeled results.