gebhart/patrepeval huggingface dataset:
StoRM-GPFS-TSM: A new approach to hierarchical storage management for the LHC experiments (2010)

The mass storage challenge for the experiments at the Large Hadron Collider (LHC) is still nowadays a critical issue for the various Tier-1 computing centres and the Tier-0 centre involved in the custodial and analysis of the data produced by the experiments. In particular, the requirements for the tape mass storage systems are quite strong, amounting to about 15 PB of data produced annually that should be available for near-line access at any time. Besides the solutions already widely employed by the High Energy Physics community so far, INFN-CNAF has approched, in the last year, a solution based on the collaboration between the General Parallel File System (GPFS) and the Tivoli Storage Manager (TSM) by IBM and StoRM as Storage Resource Management (SRM) interface, developed at INFN. The new features available in GPFS version 3.2 allow in general to interface GPFS with any tape storage manager. We implemented such an interface for TSM, and we performed various performance studies on a prototype testbed system. The first StoRM/GPFS/TSM based system is already in production at CNAF for T1D1 Storage Class; it is used by the LHCb experiment. Currently we are performing new tests to exploit features implemented in the new versione of TSM 6.1. These features are focused in high performance and optimized access to the tape backend. We will describe the implementation of the interface and details of the prototype testbed for T1D0 SC and we will discuss the results of the LHCb production system.
Formulation of deep reinforcement learning architecture toward autonomous driving for on-ramp merge (2017)

Multiple automakers have in development or in production automated driving systems (ADS) that offer freeway-pilot functions. This type of ADS is typically limited to restricted-access freeways only, that is, the transition from manual to automated modes takes place only after the ramp merging process is completed manually. One major challenge to extend the automation to ramp merging is that the automated vehicle needs to incorporate and optimize long-term objectives (e.g. successful and smooth merge) when near-term actions must be safely executed. Moreover, the merging process involves interactions with other vehicles whose behaviors are sometimes hard to predict but may influence the merging vehicle's optimal actions. To tackle such a complicated control problem, we propose to apply Deep Reinforcement Learning (DRL) techniques for finding an optimal driving policy by maximizing the long-term reward in an interactive environment. Specifically, we apply a Long Short-Term Memory (LSTM) architecture to model the interactive environment, from which an internal state containing historical driving information is conveyed to a Deep Q-Network (DQN). The DQN is used to approximate the Q-function, which takes the internal state as input and generates Q-values as output for action selection. With this DRL architecture, the historical impact of interactive environment on the long-term reward can be captured and taken into account for deciding the optimal control policy. The proposed architecture has the potential to be extended and applied to other autonomous driving scenarios such as driving through a complex intersection or changing lanes under varying traffic flow conditions.
The Catecholamine, Cortisol, and Hemodynamic Responses to Mild Perioperative Hypothermia  (1995)

Compared with patients in the forced-air warming group, patients receiving routine thermal care had lower core temperatures, a greater degree of peripheral vasoconstriction, higher norepinephrine concentrations, and higher arterial blood pressures in the early postoperative period. These findings suggest a possible mechanism for hypothermia-related cardiovascular morbidity in the perioperative period.
Organic-free synthesis of zincoaluminosilicate zeolites from homogeneous gels prepared by a co-precipitation method (2017)

Zeolites containing Zn in their frameworks are promising materials for ion-exchange and catalysis because of their unique ion-exchange capabilities and characteristic Lewis acidity. However, expensive organic compounds often required in their synthesis can prevent their practical uses. Here, a facile organic-free synthesis route for new zincoaluminosilicate zeolites having MOR topology, in which both Zn and Al are substituted in the framework, is demonstrated for the first time. The use of homogeneous zincoaluminosilicate gels prepared by a co-precipitation technique as raw materials is vital for the successful incorporation of both Zn and Al into the zeolite frameworks as revealed by several characterization techniques including solid-state NMR and UV-vis spectroscopy, and ion-exchange experiments. The obtained zincoaluminosilicate zeolites had high Zn contents comparable to those in the initial zincoaluminosilicate gels. In contrast, the uses of conventional sources of Si, Al, and Zn resulted in zeolites with very low contents of framework Zn or zeolites with extra-framework zinc oxide-species. FT-IR measurements using probe molecules and ion-exchange experiments suggested that there are two different environments of Zn in the zeolite frameworks. The obtained zincoaluminosilicate zeolites showed a higher ion-exchange efficiency for divalent cations such as nickel compared to the aluminosilicate analog. It is expected that the present co-precipitation technique is efficient for the incorporation of Zn (and other metals) into a variety of zeolite frameworks. To show its extended applicable scope, the synthesis of zincoaluminosilicate *BEA zeolite is also demonstrated.
Studies on Lignin. X. The Identity and Structure of Spruce Lignins Prepared by Different Methods (1933)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Lignin. X. The Identity and Structure of Spruce Lignins Prepared by Different MethodsFritz Brauns and Harold HibbertCite this: J. Am. Chem. Soc. 1933, 55, 11, 4720–4727Publication Date (Print):November 1, 1933Publication History Published online1 May 2002Published inissue 1 November 1933https://pubs.acs.org/doi/10.1021/ja01338a070https://doi.org/10.1021/ja01338a070research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing (2018)

Mechanosensation electronics (or Electronic skin, e-skin) consists of mechanically flexible and stretchable sensor networks that can detect and quantify various stimuli to mimic the human somatosensory system, with the sensations of touch, heat/cold, and pain in skin through various sensory receptors and neural pathways. Here we present a skin-inspired highly stretchable and conformable matrix network (SCMN) that successfully expands the e-skin sensing functionality including but not limited to temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity. The actualized specific expandable sensor units integrated on a structured polyimide network, potentially in three-dimensional (3D) integration scheme, can also fulfill simultaneous multi-stimulus sensing and achieve an adjustable sensing range and large-area expandability. We further construct a personalized intelligent prosthesis and demonstrate its use in real-time spatial pressure mapping and temperature estimation. Looking forward, this SCMN has broader applications in humanoid robotics, new prosthetics, human-machine interfaces, and health-monitoring technologies.
Plague Immunization. VI. Vaccination with the Fraction I Antigen of Yersinia pestis (1974)

The vaccination of man against plague with Fraction I (FI), the specific capsular antigen of Yersinia pestis, stimulates significant mouse-protective indices (MPI) in approximately two-thirds of those inoculated subcutaneously, and the immunity persists for three months. Revaccination with FI raises the antibody levels of nearly 95% of previously immunized individuals to an extent rarely encountered in studies of plague vaccine. The MPI recorded are roughly equivalent to those observed in the sera of patients convalescing from plague. Although FI may cause delayed allergic reactions, the evidence is conclusive that it is an antigen of major importance among the "dead" Y. pestis vaccines currently in use.
Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub>/CNT and Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub>/Graphene Nanocomposite for Li-Ion Batteries (2010)

Abstract not Available.
Lutein and Brain Function (2015)

Lutein is one of the most prevalent carotenoids in nature and in the human diet. Together with zeaxanthin, it is highly concentrated as macular pigment in the foveal retina of primates, attenuating blue light exposure, providing protection from photo-oxidation and enhancing visual performance. Recently, interest in lutein has expanded beyond the retina to its possible contributions to brain development and function. Only primates accumulate lutein within the brain, but little is known about its distribution or physiological role. Our team has begun to utilize the rhesus macaque (<i>Macaca mulatta</i>) model to study the uptake and bio-localization of lutein in the brain. Our overall goal has been to assess the association of lutein localization with brain function. In this review, we will first cover the evolution of the non-human primate model for lutein and brain studies, discuss prior association studies of lutein with retina and brain function, and review approaches that can be used to localize brain lutein. We also describe our approach to the biosynthesis of <sup>13</sup>C-lutein, which will allow investigation of lutein flux, localization, metabolism and pharmacokinetics. Lastly, we describe potential future research opportunities.
Adhesive Vesicles through Adaptive Response of a Biobased Surfactant (2010)

Kaviar für Chemiker: Reizempfindliche Vesikel aus einem Cardanol-Taurin-Tensid werden beschrieben. Temperaturabhängige Veränderungen in den ungesättigten Einheiten der Alkylketten, ähnlich homöoviskosen Veränderungen, führen zu einer Umwandlung von Micellen in Vesikel, die wie Kaviar zusammenkleben (siehe Photo).
Mechanical and Abrasive Wear Behavior of Metal Sulphide Lubricant Filled Epoxy Composites (2013)

The present work reveals the effect of the addition of commercial MoS 2 (10 wt%) particles on mechanical and two-body abrasive wear behavior of epoxy with/without glass fiber mat reinforcement. The composites were fabricated using casting and simple hand lay-up techniques followed by compression molding. The mechanical properties such as density, hardness, tensile, and flexural properties were determined as per ASTM standards. The abrasive wear testing was carried out using pin-on-disc wear tester for different loads and abrading distances at constant speed of 1 m/s. A significant reduction in wear loss and specific wear rate was noticed after the incorporation of MoS 2 filler allowing less wear of matrix during abrasion which in turn facilitated lower fiber damage. However the incorporation of MoS 2 particles had a detrimental effect on most of the mechanical properties of the composites. The worn surface features were investigated through scanning electron microscopy (SEM) in order to investigate the wear mechanisms.
Desperate housewives get legal backing (2005)

Extract: You were probably attracted to the headline because of your familiarity with the television series of the same name. However, "desperate housewives" exist in real life, and a phenomenon known to psychiatrists and psychologists as the "Battered Wife Syndrome" has received quite a lot of attention from our criminal courts in recent years. In fact, itâs reached the stage where women who murder their husbands or partners at the end of a long history of physical, verbal, sexual or emotional abuse have been given what amounts to their own set of laws, in the sense that theyâre judged by different societal standards from other so-called "murderers".
A phase I study of the novel immunotoxin, MT-5111, in subjects (subj) with HER-2 positive tumors: Interim results. (2020)

e15567 Background: Engineered toxin bodies (ETBs), composed of a Shiga-like Toxin A subunit genetically fused to antibody-like binding domains, can force receptor internalization, self-route through intracellular compartments to the cytosol, and induce potent cell-kill via the enzymatic and permanent inactivation of ribosomes. MT-5111, a de-immunized 55 kD ETB targeting HER2 in solid tumors, binds to an epitope distinct from and non-competitive with trastuzumab and pertuzumab. Methods: The primary objective is to determine the maximum tolerated dose (MTD) of MT-5111 monotherapy in adults with advanced HER2+ solid tumors. Secondary objectives are pharmacokinetics, efficacy, and immunogenicity. Part 1 will identify the MTD via MT-5111 dose escalation (0.5, 1.0, 2.0, 3.0, 4.5, 6.75, 10 µg/kg/dose) according to a modified 3+3 design. Part 2 will further evaluate the safety of MT-5111 at the recommended phase 2 dose (RP2D) in 3 separate cohorts of subjs with a HER2 immunohistochemistry score ≥2 in a metastatic lesion of primary breast, gastroesophageal, or other cancers. All subjs receive MT-5111 as a 30-minute IV infusion on Days 1, 8, and 15 of each 21-day treatment (tx) cycle (C) until disease progression, unacceptable toxicity, death, or withdrawn consent. Details can be found on clinicaltrials.gov (NCT04029922). Results: The first cohort (0.5 µg/kg/dose) enrolled 4 subjs (metastatic breast cancer, n = 2; metastatic cholangiocarcinoma, n = 2). Three subjs were female and the mean age was 69 years (median 65, range 64-78). Subjs received a mean of 5 prior lines of therapy (median 4.5, range 3-8). Three subjs completed C1 of tx without dose-limiting toxicities; 1 subj was inevaluable. Two subjs had progressive disease in C2. A total of 23 AEs occurred in 4 subjs; all were grade (G) 1-2 except one G3 event of hypertension in a subj with a history of hypertension. There were 2 tx-related AEs (G1 chills; G2 aspartate aminotransferase increased in the setting of progressive liver metastases). There was 1 serious, non-tx-related AE (G2 dyspnea) that occurred in the inevaluable subj. No cardiac AEs were noted, nor clinically significant changes in cardiac biomarkers, an important safety parameter given non-human primate toxicity. Conclusions: MT-5111 appears to be well tolerated at the lowest dose with no apparent cardiotoxicity to date. Drug concentrations are expected to be below the level required for in vitro tumor cell killing. Safety and efficacy data from subsequent dose escalation cohorts are expected by May 2020. Clinical trial information: NCT04029922.
The Pharmacokinetics of Cinacalcet are Unaffected Following Consumption of High- and Low-Fat Meals (2007)

Cinacalcet HCl reduces iPTH, serum calcium, serum phosphorus, and the calcium-phosphorus product in patients with chronic kidney disease and secondary hyperparathyroidism who are receiving dialysis, and reduces elevated serum calcium associated with primary hyperparathyroidism and parathyroid carcinoma. Cinacalcet is administered orally, and thus concomitant administration with food may affect its bioavailability. The objective of this study was to examine the effect of fat and caloric intake on cinacalcet exposure. This phase 1, randomized, open-label, single-dose, 3-period, 3-treatment, 6-sequence crossover study enrolled 30 healthy subjects (19 men, 11 women) to receive a single oral dose of cinacalcet HCl (Sensipar/Mimpara; Amgen Inc. Thousand Oaks, CA) (90 mg) on 3 separate occasions: following a high-fat, high-caloric meal, a low-fat, low-caloric meal, and a 10-hour fast. Blood samples were obtained predose and up to 72 hours postdose for pharmacokinetic (AUCinfinity, Cmax) and safety evaluations. Twenty-nine subjects completed all the 3 treatment conditions. The mean (90% confidence intervals) AUCinfinity following high- and low-fat meals was increased by 68 (48 to 89)% and 50 (33 to 70)%, respectively, relative to fasting. The difference in mean AUCinfinity between high- and low-fat meals was small [12 (9.9-26)%]. The mean tmax of cinacalcet was prolonged in fasting subjects (6 h) in relation to high-fat (4 h) and low-fat (3.5 h) fed subjects. The mean t1/2beta was similar between treatment conditions. Adverse events (AE) were observed at a similar frequency across the treatment conditions [high fat (34%), low fat (23%), and fasting (31%)]; the type of AE did not differ among the treatment conditions. The most common treatment-related AEs were headache 6/30 (20%), nausea 5/30 (17%), and dyspepsia 4/30 (13%) subjects. Administration of cinacalcet with either high- or low-fat meals results in significant increases in exposure, relative to administration under fasting conditions. However, the small differences observed in exposure following the ingestion of the different types of meals suggest that although food has a significant effect, the type of food does not. The observed effect supports the labeling statement that cinacalcet be taken with food, or shortly after a meal.
Recent advances of ionic liquids in separation science and mass spectrometry (2012)

Ionic liquids (ILs) have drawn considerable interest for their use in various analytical techniques including chromatography, extractions, and mass spectrometry. This is largely due to the flexibility in tuning the physicochemical properties of ILs. There has been a significant increase in the number of publications over the last decade in which ILs have been employed as a chromatographic stationary phase, extraction solvent, or sorbent material in various preconcentration techniques. This review article highlights the recent advancements in the use of ILs in separation science including gas chromatography, high-performance liquid chromatography, capillary electrophoresis, extraction and microextraction techniques as well as mass spectrometry.
Synthesis, structure, and superconducting properties of new high-pressure forms of tin phosphide (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, structure, and superconducting properties of new high-pressure forms of tin phosphidePaul C. DonohueCite this: Inorg. Chem. 1970, 9, 2, 335–337Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/ic50084a032https://doi.org/10.1021/ic50084a032research-articleACS PublicationsRequest reuse permissionsArticle Views619Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Reference Gene, High-mobility-group protein I/Y, Used in Qualitative and Real-Time Quantitative Polymerase Chain Reaction Detection of Transgenic Rapeseed Cultivars (2005)

With the development of transgenic crops, regulations to label the genetically modified organisms (GMOs) and their derived products have been issued in many countries. Polymerase chain reaction (PCR) methods are thought to be reliable and useful techniques for qualitative and quantitative detection of GMOs. These methods are generally needed to amplify the transgene and compare the amplified results with that of a corresponding reference gene to get the reliable results. Specific primers were developed for the rapeseed (Brassica napus), high-mobility-group protein I/Y(HMG-I/Y) single-copy gene and PCR cycling conditions suitable for the use of this sequence as an endogenous reference gene in both qualitative and quantitative PCR assays. Both methods were assayed with 15 different rapeseed varieties, and identical amplified products were obtained with all of them. No amplification was observed when templates were the DNA samples from the other species of Brassica genus or other species, such as broccoli, stem mustard, cauliflower, Chinese cabbage, cabbage, sprouts, Arabidopsis thaliana, carrot, tobacco, soybean, mung bean, tomato, pepper, eggplant, plum, wheat, maize, barley, rice, lupine, and sunflower. This system was specific for rapeseed. Limits of detection and quantitation in qualitative and quantitative PCR systems were about 13 pg DNA (about 10 haploid genomes) and about 1.3 pg DNA (about 1 haploid genome), respectively. To further test the feasibility of this HMG-I/Y gene as an endogenous reference gene, samples containing transgenic rapeseed GT73 with the inserted glyphosate oxidoreductase (GOX) gene were quantitated. These demonstrated that the endogenous PCR detection systems were applicable to the qualitative and quantitative detection of transgenic rapeseed.
Pseudo-random modulation of a laser diode for generating ultrasonic longitudinal waves (2000)

The use of lasers to generate ultrasound at the surface of a material with greater signal amplitude by simply increasing laser power eventually will lead to surface damage. In order to remain below this threshold of material damage yet increase the amplitude of the ultrasonic signal, researchers have reported experimenting with temporal modulation of high power laser. While these methods demonstrated signal improvements, they required the use of high power lasers and complicated electro-optical systems. The method demonstrated here uses a low power laser diode that is modulated by controlling the diode’s drive current with a 2 ms long pseudo-random sequence and the resulting signal is recovered by correlation. This modulated 150 mW diode laser produced a surface power density at the test article on the order of 104 W/cm2, well below any material damage threshold. The system successfully generated ultrasonic bulk waves in aluminum and composite materials and the results were comparable to the ultrasound generated with a high powered Q-switched laser within the bandwidth tested. This method also has the ability to vary signal bandwidths, a desirable trait that is lacking in more conventional laser-based methods.