gebhart/patrepeval huggingface dataset:
Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity. (2008)

The prostate cancer HERV-K gag-related NGO-Pr-54 antigen was identified by SEREX analysis using autologous patient serum. NGO-Pr-54 mRNA was observed to be faintly expressed in normal prostate and strongly expressed in a variety of cancers, including ovarian cancer (5/8), prostate cancer (6/9), and leukemia (5/14). A phage plaque assay showed that a strong reaction was constantly observed with clone ZH042 in which the 5' end of NGO-Pr-54 is deleted, suggesting that it contained the sequence coding for the protein product. A TI-35 mAb was produced using a recombinant protein (438 aa) deduced from the sequence of ZH042. Transfection of clone ZH042 into 293T cells resulted in the production of an approximately 50-kDa molecule visualized by Western blotting. Natural production of the molecule was confirmed in a SK-MEL-23 melanoma cell line. An indirect immunofluorescence assay showed that NGO-Pr-54 protein was expressed on the cell surface as well as in the cytoplasm. Cell surface expression was confirmed by flow cytometry using the TI-35 mAb. The antibody response against NGO-Pr-54 was observed in patients with bladder (5.1%), liver (4.1%), lung (3.4%), ovarian (5.6%), and prostate (4.2%) cancer, as well as with malignant melanoma (13.2%).
Permethrin-Resistant Human Head Lice, Pediculus capitis, and Their Treatment (2003)

The presence of the T929I and L932F mutations was confirmed by DNA sequencing in lice collected from children in south Florida that were resistant to the pediculicidal effects of permethrin and the leading permethrin-based head lice product, Nix. Malathion resistance was not observed in this study. The data also show that Ovide killed these same permethrin-resistant head lice approximately 10 times faster than permethrin or Nix.
Liver Tumors Following Cirrhosis Caused by Selenium in Rats (1943)

Novel transcriptional targets were discovered showing a significant differential expression in LSCs and blasts from pedAML patients compared to their normal counterparts from healthy controls. Deregulated pathways, including immune and metabolic dysregulation, were addressed for the first time in children, offering a deeper understanding of the molecular pathogenesis. These novel targets have the potential of acting as biomarkers for risk stratification, follow-up, and targeted therapy. Multiple LSC-downregulated targets endow tumor suppressor roles in other cancer entities, and further investigation whether hypomethylating therapy could result into LSC eradication in pedAML is warranted.
Processing of Titanium Foams (2004)

Abstract Because of their excellent mechanical properties, low density and biocompatibility, titanium foams are attractive for structural and biomedical applications. This paper reviews current techniques for titanium foam processing, which are all based on powder‐metallurgy because of the extreme reactivity of liquid titanium. A first group of processes is based on powder sintering with or without place‐holder or scaffolds. A second group relies on expansion of pressurized pores created during prior powder densification.
LFI: A practical and general library-level fault injector (2009)

Fault injection, a critical aspect of testing robust systems, is often overlooked in the development of general-purpose software. We believe this is due to the absence of easy-to-use tools and to the extensive manual labor required to perform fault injection tests. This paper introduces LFI (library fault injector), a tool that automates the preparation of fault scenarios and their injection at the boundary between shared libraries and applications. LFI extends prior work by automatically profiling fault behaviors of libraries via static analysis of their binaries, thus reducing the dependence on human labor and perfect documentation. We present techniques for automatically generating injection scenarios and we describe a simple language for expressing such scenarios. LFI does not require access to libraries' source code and works for Linux, Windows, and Solaris on x86 and SPARC platforms.
A 100 MHz 8 bit CMOS interpolating A/D converter (2002)

A 100-MHz 8 bit A/D (analog-to-digital) converter realized in a standard 1.5 /spl mu/m CMOS technology is presented. By implementing a current interpolating technique, the input capacitance has been reduced compared to that of flash converter. As this current interpolating circuit is an analog preprocessing circuit, the speed is mainly determined by the comparators and the digital decoding logic. A novel high-speed, single-clock-phase current latch has been developed. The latch is combined with a decoder and error correcting circuit in true single clock phase logic, which allows sampling frequencies up to 100 MHz.
Neuroendocrine mechanism of onset of puberty. Sequential reduction in activity of inhibitory and facilitatory N-methyl-D-aspartate receptors. (1992)

In humans and in several animal species, puberty results from changes in pulsatile gonadotropin-releasing hormone (GnRH) secretion in the hypothalamus. In particular, the frequency of pulsatile GnRH secretion increases at the onset of puberty, as can be shown by using hypothalamic explants of male rats of 15 and 25 d. Previous observations from us and others suggested that the initiation of puberty could involve a facilitatory effect of excitatory amino acids mediated through N-methyl-D-aspartate (NMDA) receptors. We found that GnRH secretion could be activated through NMDA receptors only around the time of onset of puberty (25 d). The aim of this study was to clarify why this activation did not occur earlier (at 15 d) and could no longer be observed by the end of puberty (at 50 d). We studied GnRH secretion in the presence of MK-801, a noncompetitive antagonist of NMDA receptors or AP-5, a competitive antagonist. We showed that, in the hypothalamus of immature male rats (15 d), a highly potent inhibitory control of pulsatile GnRH secretion in vitro was mediated through NMDA receptors. These data were confirmed in vivo because administration of the antagonist MK-801 (0.001 mg/kg) to immature male rats resulted in early pubertal development. Onset of puberty (25 d) was characterized by the disappearance of that NMDA receptor-mediated inhibition, thus unmasking a facilitatory effect also mediated through NMDA receptors. During puberty, there was a reduction in activity of this facilitatory control which was no longer opposed by its inhibitory counterpart. We conclude that a sequential reduction in activity of inhibitory and facilitatory NMDA receptors provides a developmental basis for the neuroendocrine mechanism of onset of puberty.
An Aryl to Imidoyl Palladium Migration Process Involving Intramolecular C−H Activation (2007)

Biologically interesting fluoren-9-one and xanthen-9-one derivatives have been prepared by a novel aryl to imidoyl palladium migration, followed by intramolecular arylation. The fluoren-9-one synthesis appears to involve both a palladium migration mechanism and a C-H activation process proceeding through an unprecedented organopalladium(IV) hydride intermediate. The results from deuterium labeling experiments are consistent with the proposed dual mechanism.
ACCELERATING AXON GROWTH TO OVERCOME LIMITATIONS IN FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY (2009)

With new mechanistic insights into the influencing factors of peripheral nerve regeneration, the novel treatments described above could form part of an armament of synergistic therapies that could make a meaningful difference to patients with peripheral nerve injuries.
New York's 1199 in 1989: Rebuilding a Troubled Union (1991)

[Excerpt] 1199's contract campaign of 1989 resulted in more than a contract victory for 50,000 hospital and nursing home workers. It marked the moment when 1199 reconstituted itself. The method and form that reconstitution took had everything to with the peculiar history of the union and a fundamentally destabilizing leadership crisis, with the racial and ethnic diversity of the people in the union and the different kinds of work they do, and with the industry they work in. Ironically, some of the techniques used to achieve the victory, developed to compensate for structural weaknesses, reinforced those weaknesses. The union's continuing problem is to find ways of integrating its successes with its ordinary life.
A framework for using the workspace medial axis in PRM planners (2000)

Probabilistic roadmap (PRM) planners have been very successful in path planning for a wide variety of problems, especially applications involving robots with many degrees of freedom. These planners randomly sample the configuration space, building up a roadmap that connects the samples. A major problem is finding valid configurations in tight areas, and many methods have been proposed to more effectively sample these regions. By constructing a skeleton-like subset of the free regions of the workspace, these heuristics can be strengthened. The skeleton provides a concise description of the workspace topology and an efficient means of finding points with maximal clearance from the obstacles. We examine the medial axis as a skeleton, including a method to compute an approximation to it. The medial axis is a two-equidistant surface in the workspace. We form a heuristic for finding difficult configurations using the medial axis, and demonstrate its effectiveness in a planner for rigid objects in a 3D workspace.
Anomalous short channel effects in Indium implanted nMOSFETs (2002)

A long distance roll-off, occurring on Indium-doped NMOS architectures, is experimentally observed and analyzed. It is suggested that Indium is prone to a local interstitial-assisted deactivation in the junction vicinity. This interpretation is consistent with the results of material-, device- and modeling-oriented experiments. In order to recover good electrical performances, it is shown that Indium deactivation has to be reduced thanks to an interstitial-free process.
Frequency-dependent viscoelastic parameters of mouse brain tissue estimated by MR elastography (2011)

Viscoelastic properties of mouse brain tissue were estimated non-invasively, in vivo, using magnetic resonance elastography (MRE) at 4.7 T to measure the dispersive properties of induced shear waves. Key features of this study include (i) the development and application of a novel MR-compatible actuation system which transmits vibratory motion into the brain through an incisor bar, and (ii) the investigation of the mechanical properties of brain tissue over a 1200 Hz bandwidth from 600-1800 Hz. Displacement fields due to propagating shear waves were measured during continuous, harmonic excitation of the skull. This protocol enabled characterization of the true steady-state patterns of shear wave propagation. Analysis of displacement fields obtained at different frequencies indicates that the viscoelastic properties of mouse brain tissue depend strongly on frequency. The average storage modulus (G') increased from approximately 1.6 to 8 kPa over this range; average loss modulus (G″) increased from approximately 1 to 3 kPa. Both moduli were well approximated by a power-law relationship over this frequency range. MRE may be a valuable addition to studies of disease in murine models, and to pre-clinical evaluations of therapies. Quantitative measurements of the viscoelastic parameters of brain tissue at high frequencies are also valuable for modeling and simulation of traumatic brain injury.
Metal ions and oxygen radical reactions in human inflammatory joint disease (1985)

Activated phagocytic cells produce superoxide (O2-) and hydrogen peroxide (H2O2); their production is important in bacterial killing by neutrophils and has been implicated in tissue damage by activated phagocytes. H2O2 and O2- are poorly reactive in aqueous solution and their damaging actions may be related to formation of more reactive species from them. One such species is hydroxyl radical (OH.), formed from H2O2 in the presence of iron- or copper-ion catalysts. A major determinant of the cytotoxicity of O2- and H2O2 is thus the availability and location of metal-ion catalysts of OH. formation. Hydroxyl radical is an initiator of lipid peroxidation. Iron promoters of OH. production present in vivo include ferritin, and loosely bound iron complexes detectable by the 'bleomycin assay'. The chelating agent Desferal (desferrioxamine B methanesulphonate) prevents iron-dependent formation of OH. and protects against phagocyte-dependent tissue injury in several animal models of human disease. The use of Desferal for human treatment should be approached with caution, because preliminary results upon human rheumatoid patients have revealed side effects. It is proposed that OH. radical is a major damaging agent in the inflamed rheumatoid joint and that its formation is facilitated by the release of iron from transferrin, which can be achieved at the low pH present in the micro-environment created by adherent activated phagocytic cells. It is further proposed that one function of lactoferrin is to protect against iron-dependent radical reactions rather than to act as a catalyst of OH. production.
A digital transmission approach for indoor millimeter waveband systems (2002)

This paper considers an approach to digital transmission over the indoor millimeter wave radio channel, which is suitable for personal communications. After reviewing the characteristics of the millimeter wave indoor channel, a digital transmission technique known as Commutation Signaling is presented. Commutation Signaling is a simple bandwidth expanding modulation technique with multipath intersymbol interference suppression capabilities. This feature makes Commutation Signaling attractive for indoor wireless communication systems. Modems for this transmission technique can be implemented by using Surface Acoustic Wave (SAW) technology, resulting in small size portable terminals.
Namen- und Schlagwort-Reaktionen der Organischen Chemie (1999)

"Warum müssen wir diese Namenreaktionen überhaupt lernen, einige von ihnen sind doch schon über hundert Jahre alt?" lautet eine von Anfängern häufig gestellte Frage. Die Antwort darauf ist einfach: Na
Analysis of Ethylene-Vinyl Acetate Copolymers: A Combined TGA/FTIR Experiment (1994)

ADVERTISEMENT RETURN TO ISSUEPREVLab-ExptNEXTAnalysis of Ethylene-Vinyl Acetate Copolymers: A Combined TGA/FTIR ExperimentKathryn R. Williams Cite this: J. Chem. Educ. 1994, 71, 8, A195Publication Date (Print):August 1, 1994Publication History Received3 August 2009Published online1 August 1994Published inissue 1 August 1994https://doi.org/10.1021/ed071pA195RIGHTS & PERMISSIONSArticle Views1074Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Characterization of the gene encoding the immunodominant 35 kDa protein of <i>Mycobacterium leprae</i> (1995)

Analysis of the interaction between the host immune system and the intracellular parasite Mycobacterium leprae has identified a 35 kDa protein as a dominant antigen. The native 35 kDa protein was purified from the membrane fraction of M. leprae and termed MMPI (major membrane protein I). As the purified protein was not amenable to N-terminal sequencing, partial proteolysis was used to establish the sequences of 21 peptides. A fragment of the 35 kDa protein-encoding gene was amplified by the polymerase chain reaction from M. leprae chromosomal DNA with oligonucleotide primers derived from internal peptide sequences and the whole gene was subsequently isolated from a M. leprae cosmid library. The nucleotide sequence of the gene revealed an open reading frame of 307 amino acids containing most of the peptide sequences derived from the native 35 kDa protein. The calculated subunit mass was 33.7 kDa, but the native protein exists as a multimer of 950 kDa. Database searches revealed no identity between the 35 kDa antigen and known protein sequences. The gene was expressed in Mycobacterium smegmatis under the control of its own promoter or at a higher level using an 'up-regulated' promoter derived from Mycobacterium fortuitum. The gene product reacted with monoclonal antibodies raised to the native protein. Using the bacterial alkaline phosphatase reporter system, we observed that the 35 kDa protein was unable to be exported across the membrane of recombinant M. smegmatis. The 35 kDa protein-encoding gene is absent from members of the Mycobacterium tuberculosis complex, but homologous sequences were detected in Mycobacterium avium, Mycobacterium haemophilum and M. smegmatis. The availability of the recombinant 35 kDa protein will permit dissection of both antibody- and T-cell-mediated immune responses in leprosy patients.
Is Server Consolidation Beneficial to MMORPG? A Case Study of World of Warcraft (2010)

MMORPG is shown to be a killer application of Internet, with a global subscriber number increased to 17 millions in 2010. However, MMORPG servers tend to be overly provisioned because 1)such games do not have standard architectures thus dedicated hardware is assumed; 2) MMORPGs normally adopt a ``sharded design'' to resolve the scalability challenges of content production and workload distribution; and 3) a game is commonly deployed in geographically distributed data centers to protect gamers from excessive network latencies. Therefore, an operator needs to deploy dedicated hardware for each game in each datacenter, even though hardware utilization is low. In this paper, we propose a zone-based server consolidation strategy for MMORPGs, which exploits the unique locality property of players' interactions, to cut down the games' considerable hardware requirement and energy use. We evaluate the effectiveness of our strategy based on a nine-month trace from a popular MMORPG World of War craft. The evaluation results show that, with a per-hour dynamic zone reallocation policy, the server number required can be reduced by 52% and the total energy consumption can be reduced by 62%, while the user-experienced latency remains undegraded.
Attitudes About Complementary and Alternative Medicine Did Not Predict Outcome in a Homeopathic Proving Trial (2004)

Subjects classified as being provers in a proving trial did not have significantly different attitudes about CAM than nonprovers. The experience of proving the study remedy did not alter the prover's attitudes about CAM.
The Role of PDGF-BB on the Development of the Collateral Circulation after Acute Arterial Occlusion (1994)

The survival of tissues in the presence of arterial occlusion is critically dependent on the development of collateral blood vessels. Identification of the biochemical mediators and their mechanism of action is fundamental to an understanding of the evolution of the collateral circulation. The ability of PDGF-BB to promote this was evaluated in an animal model of hind limb ischaemia. In order to obtain significant quantities of this mitogen for use in our animal model, human recombinant PDGF-BB was expressed in a Chinese Hamster Ovary (CHO) cell line. The transfected CHO cells produced 544 micrograms/l of PDGF-BB in serum free medium (SFM). The 30 kDa form of PDGF-BB was purified to homogeneity as judged by silver staining and amino-acid sequencing. Purified PDGF-BB was shown to be bioactive by a cell proliferation assay. The exogenous administration of PDGF-BB enhanced the recovery of blood flow after acute arterial occlusion. The results suggest that PDGF-BB may have therapeutic value in promoting collateral development following arterial occlusion.
Novel method for clearing red blood cell debris from BacT/ALERT<sup>®</sup> blood culture medium for improved microscopic and antimycobacterial drug susceptibility test results (2007)

Even though automation in mycobacterial culture has immensely improved the detection of organisms, identification of species and antimycobacterial susceptibility testing from blood culture bottles remain cumbersome and error-prone due to the presence of intact red blood cells (RBCs). The removal or lysis of these RBCs and excessive protein from the blood components could theoretically help improve this process. The present study reports an effective method that uses ammonium chloride (NH(4)Cl) and Triton X-100 to lyse the RBCs in blood culture medium. The method was optimized by preparing various concentrations of NH(4)Cl and Triton X-100, and incubation conditions, leading to eight protocols. The lysis protocol with a concentration of 150 mM of NH(4)Cl, 0.5% Triton X-100, and 1% potassium bicarbonate, pH 7.0, and incubation at 37 degrees C for 15 min was found to be optimal. This method not only made the culture medium clear, the protein concentration decreased from 753.5+/-39.4 to 53.2+/-4.2 mg/mL in the M. tuberculosis-spiked culture medium and in the blood culture medium inoculated with the blood from tuberculosis patients. The method had no adverse effect on mycobacteria, and no depletion of M. tuberculosis colony-forming units was found. The lysate could be used for antimycobacterial susceptibility testing with no difficulty in setting the mycobacterial concentration of inoculum to 0.5 McFarland standards. Furthermore, this method had the added advantage in the microscopy and molecular methods for the speciation of Mycobacterium sp.
The use of an active drill bit for inverse VSP measurements (1989)

Vertical Seismic Profiling (VSP) is often used to provide high resolution seismic images near a wellbore. A new borehole seismic technique, the TOMEX� survey (Rector, et al., 1988), uses the vibrations produced by a drill bit as a downhole seismic energy source to produce inverse VSP data. No downhole instrumentation is required to acquire the data, and the data recording does not interfere with or delay the drilling process. Hence, there is no loss of rig time in performing the survey. These characteristics offer a method to acquire SWD (seismic-while-drilling) borehole seismic surveys. In addition, 3-D imaging around a well can be obtained at significant savings compared to conventional offset VSP imaging. The continuous signals generated by the bit during drilling are monitored with a reference sensor attached to the top of the drillstring, and the reference sensor signals are crosscorrelated with signals from surface-positioned geophones to produce inverse VSP data. Deconvolution and time shifts are then performed to remove the effects of recording the source reference trace at a location that is a considerable distance from the source. Results from tests demonstrate that these processed drill-bit source data are virtually identical to conventional forward VSP data. In using the drill bit as a downhole seismic source for inverse VSP, many of the limitations of conventional VSP are overcome. Several applications for VSP that were previously considered to be prohibitively expensive are now feasible. Furthermore, this seismic-while-drilling technique offers the potential for the explorationist to make real-time drilling decisions at the well site.