gebhart/patrepeval huggingface dataset:
Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells (2003)

Atherosclerotic lesions preferentially develop in areas of the vasculature exposed to nonlaminar blood flow and low fluid shear stress, whereas laminar flow and high fluid shear stress are athero-protective. We have identified a set of genes including NAD(P)H:quinone oxidoreductase-1 (NQO1), heme oxygenase-1 (HO-1), ferritin (heavy and light chains), microsomal epoxide hydrolase, glutathione S-transferase, and gamma-glutamylcysteine synthase, whose expression is induced by exposure to prolonged physiological levels of steady laminar flow (shear stress = 20 dyn/cm(2)) in endothelial cells (EC). These genes contain an antioxidant response element (ARE) or ARE-like transcriptional regulatory sequence in their promoters and generally function to protect cells against oxidant stress. We demonstrate that exposure of EC to laminar flow activates ARE-mediated transcriptional activity. Mutation of the ARE from either the NQO1 or HO-1 promoter abolished laminar flow-induced NQO1 and HO-1 transcriptional activation. Expression of antisense Nrf2 (a transcriptional factor for ARE), a dominant negative Nrf2, or the cytoplasmic inhibitor of Nrf2 (Keap1/INrf2) inhibited laminar flow-induced NQO1 promoter activation in EC. In addition, expression of NQO1 or Nrf2 inhibited tumor necrosis factor-alpha-induced activation of VCAM-1 (vascular cell adhesion molecule-1) gene expression in EC. These data define the ARE as a novel endothelial shear stress response element. Furthermore, laminar flow activation of antioxidant genes via an ARE-dependent transcriptional mechanism may represent a novel athero-protective and anti-inflammatory mechanism in the vasculature.
Influence of albuterol on erythropoietin production and erythroid progenitor cell activation (1979)

The effect of albuterol, a potent beta2-adrenergic agonist, on kidney production of erythropoietin (Ep) was studied. Its effects on erythroid colony (CFU-E) formation in vitro in rabbit bone marrow cultures were also assessed. Albuterol produced a significant increase in plasma Ep levels in conscious rabbits following 7 h intravenous infusion (50 (microgram/kg)/min). This effect was blocked by pretreatment of the rabbits with butoxamine (5 mg/kg ip), a potent beta2-adrenergic blocker. Albuterol in doses of 10(-10) to 10(-8) M in combination with Ep was also found to produce a significant increase in the numbers of CFU-E in the plasma clot culture system of rabbit bone marrow. This effect was blocked completely by DL-propranolol (10(-8) M) and by butoxamine (10(-8) M). The data presented suggest that albuterol, a potent activator of beta2-adrenergic receptors, increases kidney production of Ep in vivo and also produces a direct effect in combination with Ep on the proliferation of the erythroid progenitor cell compartment.
All ink-jet-printed carbon nanotube thin-film transistor on a polyimide substrate with an ultrahigh operating frequency of over 5 GHz (2008)

We report a flexible carbon nanotube (CNT) thin-film transistor (TFT) fabricated solely by ink-jet printing technology. The TFT is top gate configured, consisting of source and drain electrodes, a carrier transport layer based on an ultrapure, high-density (&gt;1000 CNTs/μm2) CNT thin film, an ion-gel gate dielectric layer, and a poly(3,4-ethylenedioxythiophene) top gate electrode. All the TFT elements are ink-jet printed at room temperature on a polyimide substrate without involving any photolithography patterning or surface pretreatment steps. This CNT-TFT exhibits a high operating frequency of over 5 GHz and an on-off ratio of over 100. Such an all-ink-jet-printed process eliminates the need for lithography, vacuum processing, and metallization procedures and thus provides a promising technology for low-cost, high-throughput fabrication of large-area high-speed flexible electronic circuits on virtually any desired flexible substrate.
Lumbar Cerebrospinal Fluid Choline in Healthy Aging and in Down's Syndrome (1990)

Choline concentrations were measured in lumbar cerebrospinal fluid (CSF) and plasma of 37 healthy normal subjects and 13 young (age range, 21 to 34 years) and 6 older (age, greater than or equal to 45 years) healthy adults with Down's syndrome (DS). All subjects with DS had a trisomy 21 karyotype, and 3 of the 6 older subjects were demented as judged from a history of mental deterioration, disorientation, and memory loss. In healthy normal subjects, there was a significant correlation between age and CSF choline concentrations. Compared with age-matched controls, in young subjects with DS, CSF, but not plasma, choline concentrations were elevated (by 49%), whereas in older subjects with DS, CSF and plasma choline concentrations were similar to control values. The CSF choline concentrations were unrelated to body height in the DS and control groups, and rostrocaudal CSF choline gradients did not differ between either the control and DS groups or the young and old subjects with DS, suggesting that the elevation in the CSF choline concentration in young subjects with DS was not related to their shorter stature. Since increased CSF choline concentrations in young adult subjects with DS were accompanied by normal plasma choline concentrations, these results suggest that young adults with DS have either an increased release of choline from the brain or a reduced rate of clearance of choline from CSF.
Evaluation of Chlorine Dioxide Gas Residues on Selected Food Produce (2010)

In recent years, the consumption of fresh fruits and vegetables has greatly increased, and so has its association with contamination of several foodborne pathogens (Listeria, Salmonella, and Escherichia coli). Hence, there is a need to investigate effective sanitizer systems for produce decontamination. Chlorine dioxide (ClO(2)), a strong oxidizing gas with broad spectrum and sanitizing properties, has previously been studied for use on selected fruits and vegetables. ClO(2) gas treatments show great potential for surface pathogen reduction; however its use from a residue safety standpoint has yet to be assessed. Thus, the objective of this study was to evaluate residues of ClO(2), chlorite, chlorate, and chloride on selected fresh produce surfaces after treatment with ClO(2) gas. A rinse procedure was used and water samples were analyzed by N, N-diethyl-p-phenylenediamine and ion chromatography method (300.0). Seven different foods--tomatoes, oranges, apples, strawberries, lettuce, alfalfa sprouts, and cantaloupe--were analyzed after ClO(2) treatment for surface residues. Very low residues were detectable for all the food products except lettuce and alfalfa sprouts, where the measured concentrations were significantly higher. Chlorine dioxide technology leaves minimal to no detectable chemical residues in several food products, thus result in no significant risks to consumers. Practical Application: Potential for chlorine dioxide gas treatments as an effective pathogen inactivation technology to produce with minimal risk for consumers.
Domain specific reconfigurable fabric targeting Viterbi algorithm (2005)

This work presents a novel embedded reconfigurable fabric targeting efficient implementation of the Viterbi decoder within a system-on-chip device. The proposed reconfigurable fabric can support constraint lengths ranging from 3 to 9, and code rates in the range 1/2-1/3.Our results demonstrate that this novel architecture has superior throughput and power consumption characteristics when compared to generic DSPs and FPGAs respectively.
EL MODELO TABULAR EN DEMOGRAFÍA: UNA LECTURA INPUT-OUTPUT (2001)

El esquema del modelo analitico conocido como demografica permite medir la influencia que sobre un unico fenomeno demografico tiene el tiempo, entendido este como duracion o edad. El presente trabajo utiliza la tecnica del analisis input-output para explicar las relaciones existentes en una tabla demografica, enriqueciendo las conclusiones que pueden extraerse de ella y permitiendo establecer la relacion entre el tiempo-calendario y el tiempo-duracion. Tambien se define una medida para valorar la diferencia entre dos tablas demograficas diferentes - referidas a momentos o a poblaciones distintas - a la hora de describir la incidencia del mismo fenomeno demografico. Se aplica la metodologia I/O expuesta a una tabla concreta, correspondiente a la nupcialidad de las mujeres espanolas en el periodo 1956-65, mientras que las tablas-tipo de mortalidad son utilizadas para ilustrar la medicion de las diferencias entre ellas.
P53 expression in breast cancer (1988)

Immunohistochemical evaluation of 200 primary breast cancers with the anti-p53 mouse monoclonal antibody (MAb) PAb421 showed positivity in nuclei of malignant cells in 31 cases (15.5%). PAb421+ cases were significantly more frequently epidermal growth factor receptor (EGF-R)-positive (67.7%; p less than 0.001) and estrogen receptor (ER)-negative (73.3%; p less than 0.001); they displayed surface histocompatibility class-1 (80.6%; p less than 0.01) and 11 (74.2%; p less than 0.05) antigens. Low values for progesterone receptor (mean 67.20 +/- 25.2 fmol/mg; p less than 0.05) and a high number of cells positive for the proliferation-associated antigen Ki-67 (log mean 6.88 +/- 0.33; p less than 0.01) were found in PAb421+ tumors as well as a high number of grade-3 infiltrating duct carcinomas (70%; p = 0.01). Of the 200 cases of mammary carcinoma, 88 were further analyzed using another human specific anti-p53 MAb PAb1801, and 40 (45.5%) were found positive. This MAb stained all the PAb421+ cases and was significantly associated with negative ER status (39.5%; p less than 0.05) and high Ki-67 scores (log mean 6.93 +/- 0.24; p = 0.001). Analysis of PAb1801+/Pab421- cases for HLA antigens, EGF-R and ER showed a phenotype similar to that of the p53-ve/ER+ carcinomas, except for the high Ki-67 score. No differences in age of the patient, number of involved nodes, tumor size, ploidy or labelling index scores were evident between p53+ and carcinomas. We concluded that p53 in mammary carcinomas is associated with ER-negative, growth factor receptor-positive, high-grade tumors, and is a promising new parameter to evaluate the cellular biology and prognosis of breast cancer.
The enzymically catalysed transfer of the deoxyribosyl group from one purine or pyrimidine to another (1952)

Research Article| January 01 1952 The enzymically catalysed transfer of the deoxyribosyl group from one purine or pyrimidine to another W. S. Macnutt W. S. Macnutt 1Institute of Cytophysiology and Biochemistry, University of Copenhagen, Denmark Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1952) 50 (3): 384–397. https://doi.org/10.1042/bj0500384 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation W. S. Macnutt; The enzymically catalysed transfer of the deoxyribosyl group from one purine or pyrimidine to another. Biochem J 1 January 1952; 50 (3): 384–397. doi: https://doi.org/10.1042/bj0500384 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1952 CAMBRIDGE UNIVERSITY PRESS1952 Article PDF first page preview Close Modal You do not currently have access to this content.
Developmental Changes in Seeds of Loblolly Pine (1991)

Mature seed weight of loblolly pine ( Pinus taeda L.) averaged 25 mg (dry weight), of which 55.0% was seedcoat, 38.5% megagametophyte, and 6.4% embryo. Fatty acid (FA) content (dry-weight basis) was 17.5% for whole seed, 0.4% for seedcoat, 36.2% for megagametophyte, and 51.2% for embryo. Distribution of FAs (16:0; 18:0; 18:1; 18:2; 18:3 Δ5,9,12; 18:3 Δ9,12,15; 20:0; and 20:3) differed in seedcoat, megagametophyte, and embryo, but 18:2 was the predominant FA in all tissues. Seed development was analyzed for 110 days from 25 July, the year following pollination. Embryos could be macroscopically observed on or about day 30. Embryo dry weight, length, and FA accumulation increased until about day 50 and then remained constant. Embryo density decreased from day 30 to 50 and then stabilized at ≈1.0366 g·ml -1 or 10% sucrose equivalent. Excised zygotic embryos did not germinate in vitro until after day 51; germination increased linearly after this date, reaching 80% by day 72.
Environmental Signals Modulate ToxT-Dependent Virulence Factor Expression in <i>Vibrio cholerae</i> (1999)

The regulatory protein ToxT directly activates the transcription of virulence factors in Vibrio cholerae, including cholera toxin (CT) and the toxin-coregulated pilus (TCP). Specific environmental signals stimulate virulence factor expression by inducing the transcription of toxT. We demonstrate that transcriptional activation by the ToxT protein is also modulated by environmental signals. ToxT expressed from an inducible promoter activated high-level expression of CT and TCP in V. cholerae at 30 degrees C, but expression of CT and TCP was significantly decreased or abolished by the addition of 0.4% bile to the medium and/or an increase of the temperature to 37 degrees C. Also, expression of six ToxT-dependent TnphoA fusions was modulated by temperature and bile. Measurement of ToxT-dependent transcription of genes encoding CT and TCP by ctxAp- and tcpAp-luciferase fusions confirmed that negative regulation by 37 degrees C or bile occurs at the transcriptional level in V. cholerae. Interestingly, ToxT-dependent transcription of these same promoters in Salmonella typhimurium was relatively insensitive to regulation by temperature or bile. These data are consistent with ToxT transcriptional activity being modulated by environmental signals in V. cholerae and demonstrate an additional level of complexity governing the expression of virulence factors in this pathogen. We propose that negative regulation of ToxT-dependent transcription by environmental signals prevents the incorrect temporal and spatial expression of virulence factors during cholera pathogenesis.
Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac Transplant Research Database. (1998)

Angiographic coronary artery disease is very common after heart transplantation, occurring in approximately 42% of the patients by 5 years. Older donor age, donor hypertension, and male donor or recipient predict earlier onset of angiographic allograft coronary artery disease. Although severe angiographic allograft coronary artery disease occurs in only 7% of the patients at 5 years, its presence is highly predictive of subsequent coronary artery disease-related events or retransplantation.
Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand (2017)

Studies of aryl phosphonate derivatives of a butyrophilin 3A1 ligand have resulted in identification of a potent stimulant of Vγ9 Vδ2 T cells. This compound, a mixed ester bearing one pivaloyloxymethyl substituent and one 1-naphthyl ester displayed an EC<sub>50</sub> of 0.79 nM as a stimulant of T cell proliferation, and a 9.0 nM EC<sub>50</sub> in an assay designed to measure interferon gamma production. In both assays, this is the most potent butyrophilin ligand prodrug yet reported, and thus it should be a valuable tool for studies of T cell function. Furthermore, mixed aryl/acyloxyalkyl esters may represent a new class of phosphonate prodrugs with high efficacy.
Evaluación de la aplicación de herramientas de mejora en la industria alimentaria de Norte de Santander (2012)

Norte de Santander, se ha caracterizado por su dependencia economica del sistema cambiario con la frontera venezolana, sin embargo en los ultimos anos los problemas economicos del vecino pais han generado que la poblacion aledana a esta frontera busque otras formas de mejorar sus ingresos y de cierta manera se ha incrementado la creacion de empresas a nivel artesanal y microempresarial. El estudio se realizo en 79 industrias registradas en la Camara de Comercio de Cucuta mediante entrevistas y encuestas, para el analisis de los datos obtenidos en el uso de las herramientas de mejora se aplico estadistica descriptiva, mediante frecuencias,  histogramas y medidas de tendencia central, arrojando que en el sector de alimentos el crecimiento industrial es debido principalmente al predominio de la industria panificadora y los servicios de alimentacion. Este tipo de empresas en particular requiere de un proceso productivo controlado en cuanto a parametros de calidad de las materias primas, insumos y producto terminado segun la normativa legal y reglamentaria que les aplica, asi como la medicion de la productividad para ser competitivos. En conclusion se encontro que l as herramientas de mayor utilizacion por las empresas son justo a tiempo con el 22.8%, mantenimiento productivo total con 16.5% y con un 10.1% la administracion de la cadena de valor. . Lo anterior unido a que el empleo informal en Cucuta es del 68% segun lo reportado por la Camara de Comercio de Cucuta, (2013).
W-band cross-coupled filters and a duplexer on a thin-film substrate for low-cost front-end integration (2009)

The development of cross-coupled bandpass filters and a duplexer for W-band transceiver applications on a thin-film substrate is presented. The filter is designed at 94 GHz using the cross-coupling method on a planar thin-film microstrip (TFMS) line platform and fabricated with a thin-film multichip module technology. The developed filter has an insertion loss of 2.5 dB with a 3-dB fractional bandwidth of 12.8%. Combining two cross-coupled filters with T-junction matching, a simple W-band duplexer is developed. The two channels of the duplexer are centered at 80 GHz and 94 GHz having channel bandwidth of 6.5 GHz and 6.7 GHz, respectively, with insertion loss less than 4.3 dB in both channel. The developed passives are compact and show good matching, selectivity, and isolation characteristics, and are suitable for low-cost W-band front-end integration.
Solution-processed conjugated polymer organic p-i-n light-emitting diodes with high built-in potential by solution- and solid-state doping (2009)

Polymer p-i-n homojunction light-emitting diodes (LEDs) comprising p-doped poly(dioctylfluorene-alt-benzothiadiazole) (F8BT) hole-injection, intrinsic F8BT emitter, and n-doped F8BT electron-injection layers have been demonstrated. A thin F8BT film was photocrosslinked and bulk p-doped by nitronium oxidation, then overcoated with an F8BT layer which was then surface n-doped by contact printing with naphthalenide on an elastomeric stamp. These LEDs exhibit high built-in potential (Vbi=2.2 V), efficient bipolar injection, and greatly improved external electroluminescence efficiency compared to control devices without the p-i-n structure. A modulated photocurrent technique was used to measure this Vbi, which systematically improves with diode structure.
ACTIONS OF ANTIFERTILITY CHEMICALS ON <i>XENOPUS LAEVIS</i> SPERMATOZOA <i>IN VITRO</i> (1974)

Summary. A test system involving fertilization in vitro of Xenopus laevis gametes was developed to study the effects of various chemosterilants on toad spermatozoa. The subsequent development of fertilized eggs indicated that effective concentrations and times of exposure were considerably greater than those likely to be achieved with antifertility doses to rodents. Low concentrations of tretamine and ethyleneurea on Xenopus spermatozoa produced high yields of abnormal embryos, whereas other epididymal sterilants active in the rat (trimethylphosphate and α-chlorhydrin) were ineffective in very high concentration. Differences between results in vitro and in vivo may be due to environmental variations or indicate an action by certain compounds on epididymal function in rodents rather than a direct action upon spermatozoa.
Veratryl alcohol as an inducer of laccase by an ascomycete, Botryosphaeria sp., when screened on the polymeric dye Poly R-478 (1996)

A.M. BARBOSA, R.F.H. DEKKER AND G.E. ST HARDY. 1996. Forty fungi isolated from diverse environments in Western Australia were screened for ligninolytic activity based on in-vivo decolorization of the polymeric dye Poly R-478. Three isolates identified as Aspergillus, Botryosphaeria and Coniochaeta species were selected for further studies. The Botryosphaeria and Coniochaeta isolates were found to produce laccase constitutively in submerged culture when grown on glucose, or on ryegrass seed by solid state fermentation. A comparison of the three isolates grown on glucose in the presence of 3,4-dimethoxybenzyl (veratryl) alcohol (40 mmol 1−1) showed that only the Botryosphaeria isolate produced laccase, with laccase activities 115-fold higher than when grown on glucose alone.
Towards a knowledge based system for the clinical evaluation of the electroencephalogram and visual evoked potentials (2002)

The objective of our research is to develop computer based tools to automate the clinical evaluation of the electroencephalogram (EEG) and visual evoked potentials (VEP). The paper describes a set of solutions to support all the aspects regarding the standard procedures of the diagnosis in neurophysiology. More specifically, the paper focuses on the description of an approach to automate the process carried out by the physician when an EEG register has to be used to obtain a diagnostic of a patient. Two main lines have been established. The first one deals with the development of support tools to aid in the technical aspects of the process: data acquisition, data compression and brain map representation. The second line is focused on the classification and learning of neurophysiological signals. A classical approach has been successfully applied to the problem of brain maturation classification.
An experiment with an S-Band radar using pulse compression and range sidelobe suppression for meteorological measurements (2002)

A major technology barrier to the application of pulse compression for the meteorological functions required by a next generation ATC radar is range/time sidelobes which mask and corrupt observations of weak phenomena occurring near areas of strong extended meteorological scatterers. Techniques for suppressing range sidelobes are well known but without prior knowledge of the scattering medium's velocity distribution their performance degrades rapidly in the presence of Doppler. Recent investigations have presented a "Doppler tolerant" range sidelobe suppression technique. The thrust of the work described herein is the extension of previous simulations to actual transmitted dispersed/coded waveforms using the S-band surveillance radar located at Rome Laboratory Surveillance Facility. The objectives of the experiment are: (1) to extend the verification of the simulation of the Doppler tolerant technique, and (2) to demonstrate that the radar transmitter, waveform generator, and receiver imperfections do not significantly degrade resolution, performance or reliability of meteorological spectral moment estimates.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
An efficient search on puncturing patterns for short polar codes (2015)

Construction of polar code via puncturing and shortening is studied. We propose a reduced full search for finding optimal puncturing pattern of short polar codes.