gebhart/patrepeval huggingface dataset:
Improving the effectiveness of nutritional information policies: assessment of unconscious pleasure mechanisms involved in food-choice decisions (2012)

The rise in obesity in many countries has led to the emergence of nutritional information policies that aim to change people's diets. Changing an individual's diet is an ambitious goal, since numerous factors influence a person's food-choice decisions, many of which are made unconsciously. These frequently subconscious processes should not be underestimated in food-choice behavior, as they play a major role in food diet composition. In this review, research in cognitive experimental psychology and neuroscience provides the basis for a critical analysis of the role of pleasure in eating behaviors. An assessment of the main characteristics of nutritional policies is provided, followed by recent findings showing that food choices are guided primarily by automatic emotional processes. Neuroimaging and behavioral studies, which provide new insights into the relationships between emotions and food both in lean persons and in persons with eating disorders, are reported as well. Lastly, the argument is presented that future nutritional policies can be more effective if they associate healthy food with eating pleasure.
Object recognition and retrieval by context dependent similarity kernels (2008)

The success of kernel methods including support vector machines (SVMs) strongly depends on the design of appropriate kernels. While initially kernels were designed in order to handle fixed-length data, their extension to unordered, variable-length data became more than necessary for real pattern recognition problems such as object recognition and bioinformatics. We focus in this paper on object recognition using a new type of kernel referred to as ldquocontext-dependentrdquo. Objects, seen as constellations of local features (interest points, regions, etc.), are matched by minimizing an energy function mixing (1) a fidelity term which measures the quality of feature matching, (2) a neighborhood criteria which captures the object geometry and (3) a regularization term. We will show that the fixed-point of this energy is a ldquocontext-dependentrdquo kernel (ldquoCDKrdquo) which also satisfies the Mercer condition. Experiments conducted on object recognition show that when plugging our kernel in SVMs, we clearly outperform SVMs with ldquocontext-freerdquo kernels.
Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant <i>Staphylococcus aureus</i> (2019)

The spread of plasmid borne resistance enzymes in clinical <i>Staphylococcus aureus</i> isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds that can broadly inhibit these resistance-conferring isoforms. Using a structure-based approach, we have developed a novel class of ionized nonclassical antifolates (INCAs) that capture the molecular interactions that have been exclusive to classical antifolates. These modifications allow for a greatly expanded spectrum of activity across these pathogenic DHFR isoforms, while maintaining the ability to penetrate the bacterial cell wall. Using biochemical, structural, and computational methods, we are able to optimize these inhibitors to the conserved active sites of the endogenous and trimethoprim resistant DHFR enzymes. Here, we report a series of INCA compounds that exhibit low nanomolar enzymatic activity and potent cellular activity with human selectivity against a panel of clinically relevant TMP resistant (TMP<sup>R</sup>) and methicillin resistant <i>Staphylococcus aureus</i> (MRSA) isolates.
Evaluating the Susceptibility of Electronic Components Assembled with Leaded Solder to Flexural Failures, with High Rate Considerations (2008)

Multilayer ceramic capacitors (MLCCs) are subjected to high strain rate flexural loading via drop tower and air gun tests, with PWB strain rates ranging from 1/s to 10/s. Three MLCC part sizes, three different manufacturers, and standard and flexible termination parts are included in the study. Standard termination capacitors failed via the well documented flex crack failure mechanism. However in all cases this crack followed a vertical path not typical of this failure mechanism. Flexible termination capacitors failed via a newly discovered failure mechanism involving delamination in the end cap metallization between the silver filled epoxy and the nickel-tin plating. For size 1206 parts, this delamination was seen in both end caps, and the part detached from the test board. For size 0603 parts, this delamination occurred in one end cap, while the opposite end cap fractured though the ceramic in a manner similar to a flex crack. Size 0603 parts also failed via the vertical flex cracks documented in standard termination parts. All of the documented failures of MLCC devices at PWB strain rates of ≥ 1/s occurred at maximum PWB strain values greater than an order of magnitude lower than those seen in lower strain rate testing. This rate dependency of MLCC part failures has vast implications for products intended for high rate environments. Additionally, when the PWB strain rate was increased along with PWB maximum strain, flexible termination capacitors performed worse than their standard termination equivalents. This brings to issue the role of these next generation parts in portable consumer electronic devices as well as other designs with high rate implications. Ball grid array (BGA) devices are subjected to four point bend tests via a servo-hydraulic testing machine at PWB strain rates ≤ 0.1/s. The resulting BGA data is found to adhere reasonably well to the Coffin-Manson low cycle fatigue relationship. Independently generated BGA data that differs with respect to many testing variables is plotted alongside the experimental data. The high correlation of the data set indicates the possibility of creating a BGA mechanical failure model that is independent of failure site, package type, and test specifications.
Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties. (1991)

Aureobasidins A to R were isolated from the fermentation broth of Aureobasidium pullulans R106. Aureobasidins are cyclic depsipeptide antibiotics with MW's ranging from 1.070 to 1,148. Aureobasidins showed high in vitro antifungal activity against Candida albicans.
Photoreceptor topography of the retina in the adult pigtail macaque (<i>Macaca nemestrina</i>) (1989)

In spite of the crucial role retinal photoreceptors play in mapping optical images into a pattern of neural excitation, there are no complete studies of photoreceptor topography in any primate retina. We have measured the spatial density and inner segment areas of cones and rods across the whole mounted retinas of three adult pigtail macaques (Macaca nemestrina) and constructed maps of photoreceptor density and inner segment diameter. These retinas contain an average of 3.1 million cones (2.8-3.3 million), with an average peak foveal cone density of 210,000 cones/mm2 (190,000-260,000 cones/mm2). Cone density falls steeply with increasing eccentricity, to 100,000 cones/mm2 at 200 microns from the fovea, and to 50,000 cones/mm2 at 750 microns. Imposed on this gradient is a "streak" of higher cone density along the horizontal meridian. At equivalent eccentricities, cone density is higher in nasal and inferior retina. Cone inner segments increase in diameter from 2.3 microns at the foveal center to 11 microns in far temporal retina and 10 microns in far nasal retina. These retinas contain an average of 60.1 million rods (44.9-75.3 million). Rod density is zero within 20 microns of the foveal center, increases to the crest of a "rod ring" at the eccentricity of the optic disk, and then declines. Central rod topography is asymmetric, with higher densities in superior retina. Density along the crest of the rod ring peaks in superior retina at 177,000 rods/mm2, dips as low as 120,000 rods/mm2 along the horizontal meridian, and increases to about 150,000 rods/mm2 in inferior retina. Far peripheral rod topography is relatively symmetric around the fovea. Rod inner segment diameter ranged from 1.5 microns in the fovea to 4 microns at the temporal edge and 3.4 microns at the nasal edge of the retina. At eccentricities exceeding 6 mm, rod inner segment diameter was greater temporally than nasally. Cone inner segments cover 85-90% of the central fovea, with extrareceptor space accounting for the remainder. Cone coverage declines with increasing eccentricity to 20% at the temporal edge and 35% at the nasal edge of the retina. In contrast, rod coverage increases from zero at the foveal center to a maximum of 65% in temporal retina and 50% in nasal retina. The photoreceptor topography of the pigtail macaque is qualitatively similar to that of other macaques and to humans. Photoreceptor topography is formed by a complex interaction between regional changes in cone and rod density and inner segment diameter.
Adaptive software rejuvenation: degradation model and rejuvenation scheme (2004)

We present a framework of adaptive estimation and rejuvenation of software system performance in the presence of aging sources. The framework specifies that a degradation model not only describe an aging process but also enable the adaptation of model-based performance estimates to on-line measurements of data pertaining to the aging process. The adaptive estimation uses model-based a priori estimation and obtains a posteriori estimation based on the data measurements. With the adaptive estimation, the rejuvenation policy determines the time epochs for data collection and rejuvenation according to system dynamics. In the specific context of resource leaks previously assumed to lead to aging, we present a non-homogeneous Markov model to explicitly establish a connection between resource leaks and the failure rate. We demonstrate an increasing failure rate in the presence of resource leaks. 1. Introduction: the Adaptation Problem We present a framework for adaptive estimation and rejuvenation of software system performance in the presence of aging sources. We are concerned with system resource loss, in particular, memory leakage. Memory is indispensable in computer and communication systems. Memory leakage is a typical aging source for server systems due to software bugs in the client applications that use server resources. Our framework for adaptive estimation and rejuvenation consists of three integral components: a degradation model, an adaptive estimation scheme, and an adaptive rejuvenation scheduling policy. The degradation model allows adaptation of model-based performance estimates to on-line measurements of data pertaining to the aging process. The adaptive estimation scheme uses the model-based a priori estimation and obtains a posteriori estimation based on the measurements. With the adaptive estimation, the rejuvenation scheduling policy determines time epochs for data
Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid enhancer binding factor-dependent transcription (2006)

Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer and often augment beta-catenin-T cell factor (Tcf)/lymphoid enhancer binding factor (Lef)-dependent transcription of genes such as c-myc and cyclin-D1. CK2 has also been implicated recently in the regulation of beta-catenin stability. To identify mechanisms by which CK2 promotes survival, effects of the specific CK2 inhibitors 4,5,6,7-tetrabromobenzotriazole (TBB) and 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole were assessed. TBB and 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole significantly decreased proliferation and increased apoptosis of HT29(US) colon cancer cells. RT-PCR and immunoblot analysis revealed that both inhibitors decreased survivin mRNA and protein levels in HT29(US) cells. Similar effects were observed with TBB in human DLD-1 and SW-480 colorectal cells as well as ZR-75 breast cancer cells and HEK-293T embryonic kidney cells. Expression of GFP-CK2alpha in HEK-293T cells resulted in beta-catenin-Tcf/Lef-dependent up-regulation of survivin and increased resistance to anticancer drugs. Augmented beta-catenin-Tcf/Lef-dependent transcription and resistance to apoptosis observed upon GFP-CK2alpha expression were abolished by TBB. Alternatively, HEK-293T cells expressing GFP-survivin were resistant to TBB-induced apoptosis. Finally, siRNA-mediated down-regulation of CK2alpha in HEK-293T cells coincided with reduced beta-catenin and survivin levels. Taken together, these results suggest that CK2 kinase activity promotes survival by increasing survivin expression via beta-catenin-Tcf/Lef-mediated transcription. Hence, selective CK2 inhibition or down-regulation in tumors may provide an attractive opportunity for the development of novel cancer therapies.
Association between Adipose Tissue Interleukin-33 and Immunometabolic Markers in Individuals with Varying Degrees of Glycemia (2019)

IL-33 and/or IL-33/ST2 dynamics and biological functions may play a role in overall glycemia among humans and may represent a novel target by which glucose-lowering managements confer their beneficial effects.
Optimal update with out-of-sequence measurements (2005)

This paper is concerned with optimal filtering in a distributed multiple sensor system with the so-called out-of-sequence measurements (OOSM). Based on best linear unbiased estimation (BLUE) fusion, we present two algorithms for updating with OOSM that are optimal for the information available at the time of update. Different minimum storages of information concerning the occurrence time of OOSMs are given for both algorithms. It is shown by analysis and simulation results that the two proposed algorithms are flexible and simple.
Handling of a Semiclosed Cycle Gas Turbine With a Carbon Dioxide-Argon Working Fluid (1999)

This paper outlines the handling of a semi closed cycle gas turbine, its working fluid is carbon dioxide and the fuel is low heating value gas from coal. At startup however, air and natural gas are used. The objective of the machine is to produce clean electricity with the smallest efficiency penalty. Many aspects of the operation of the engine are examined here; these include starting requirements, stator vane and bleed valve scheduling and the working fluid transition from air to carbon dioxide. Other features highlighted are the compressor operating lines and surge margins. The present paper describes the salient features of the three main stages into which the engine operation has been divided. These stages are: startup to synchronous idle, change of working fluid (from air to Carbon Dioxide-Argon) and fuel (from natural gas to coal synthetic gas) at synchronous idle and part load operation. Preliminary findings show that engine handling can be carried out effectively with variable stators. This is possible because of the two shaft gas generator. Another point of interest is the large increase of corrected speed relative to rotational speed experienced when the working fluid changes from air to carbon dioxide. In general the control of the engine does not seem to present any insurmountable problems despite the complexities arising from the need to change working fluid and fuel.
Vibrational Energy Transport through a Capping Layer of Appropriately Designed Peptide Helices over Gold Nanoparticles (2010)

We design and characterize spherical gold nanoparticles, which are covalently linked to and completely covered by 3(10)-helical peptides. These helices provide a scaffold to place (13)C=O isotope labels at defined distances from the gold surface, which we employ as local thermometers. Probing these reporter groups with transient infrared spectroscopy, we monitor the vibrational energy flow across the peptide capping layer following excitation of the nanoparticle plasmon resonance.
High Density Lipoprotein: Assembly, Structure, Cargo, and Functions (2013)

Cardiovascular disease (CVD) is the leading cause of death globally. For close to four decades, we have known that high density lipoprotein (HDL) levels are inversely correlated with the risk of CVD. HDL is a complex particle that consists of proteins, phospholipids, and cholesterol and has the ability to carry micro-RNAs. HDL is constantly undergoing remodelling throughout its life-span and carries out many functions. This review summarizes many of the different aspects of HDL from its assembly, the receptors it interacts with, along with the functions it performs and how it can be altered in disease. While HDL is a key cholesterol efflux particle, this review highlights the many other important functions of HDL in the innate immune system and details the potential therapeutic uses of HDL outside of CVD.
Spatial Operator Algebra for multibody system dynamics (1992)

This paper describes a new spatial operator algebra for the dynamics of general-topology rigid multibody systems. Spatial operators allow a concise and systematic formulation of the dynamical equations of motion of multibody systems and the development of efficient computational algorithms. Equations of motion are developed for progressively more complex systems: serial chains, topological trees, and closed-loop systems. New operator factorizations and expressions for the mass matrix and its inverse are derived and used to obtain efficient, spatially recursive computational algorithms. The algorithms can be easily reconfigured in response to changes in the constraints and the topology of constituent bodies. Thus, they are particularly suited for time-varying multibody systems. References are provided for extensions to flexible multibody systems. Spatially recursive algorithms, based on the sequential filtering and smoothing methods encountered in optimal estimation theory, provide the computational infrastructure to mechanize the spatial operators.
Interference Analysis for Highly Directional 60-GHz Mesh Networks: The Case for Rethinking Medium Access Control (2011)

We investigate spatial interference statistics for multigigabit outdoor mesh networks operating in the unlicensed 60-GHz “millimeter (mm) wave” band. The links in such networks are highly directional: Because of the small carrier wavelength (an order of magnitude smaller than those for existing cellular and wireless local area networks), narrow beams are essential for overcoming higher path loss and can be implemented using compact electronically steerable antenna arrays. Directionality drastically reduces interference, but it also leads to “deafness,” making implicit coordination using carrier sense infeasible. In this paper, we make a quantitative case for rethinking medium access control (MAC) design in such settings. Unlike existing MAC protocols for omnidirectional networks, where the focus is on interference management, we contend that MAC design for 60-GHz mesh networks can essentially ignore interference and must focus instead on the challenge of scheduling half-duplex transmissions with deaf neighbors. Our main contribution is an analytical framework for estimating the collision probability in such networks as a function of the antenna patterns and the density of simultaneously transmitting nodes. The numerical results from our interference analysis show that highly directional links can indeed be modeled as pseudowired, in that the collision probability is small even with a significant density of transmitters. Furthermore, simulation of a rudimentary directional slotted Aloha protocol shows that packet losses due to failed coordination are an order of magnitude higher than those due to collisions, confirming our analytical results and highlighting the need for more sophisticated coordination mechanisms.
Radical Copolymerization of Vinylidene Fluoride (VDF) with Oligo(hexafluoropropylene oxide) Perfluorovinyl Ether Macromonomer To Obtain PVDF-<i>g</i>-oligo(HFPO) Graft Copolymers (2015)

The synthesis of PVDF-g-oligo(HFPO) graft copolymers, where VDF and HFPO stand for vinylidene fluoride and hexafluoropropylene oxide, respectively, is presented. First, an oligo(HFPO)–OCF═CF2 macromonomer was prepared from two methods starting from oligo(HFPO) acyl fluoride in 34 to 54% yield. Then, the radical copolymerization of VDF with that comonomer, initiated by tert-butyl peroxypivalate (TBPPi) or perfluoro-3-ethyl-2,4-dimethyl-3-pentyl persistent radical (PPFR) was studied under various conditions. The resulting PVDF-g-oligo(HFPO) graft copolymers were produced in good isolated yields (74 to 89%). The molar percentages and molecular weights of the graft copolymers were assessed by 19F and 1H NMR spectroscopy. Molar percentages of VDF and oligo(HFPO)–OCF═CF2 comonomers reached up to 99% and 11%, respectively, while the molecular weights ranged from 25 000 to 77 000 g/mol. Their thermal properties were also studied and showed: (1) satisfactory thermostability (Td) in the 410 to 494 °C range under air and (2) melting temperature (Tm) between 138 to 159 °C, while (3) the glass transition (Tg) ranged from −79 to −54 °C.
The Heart of America (1943)

Do not allow Pete to deceive you with his modern ideas and speeches. He is really quite a character from out of the old world with all his old-fashioned ways. Italy can boast of the birth of one Peter Galbo about half a century ago. Having been reared there until he was eighteen years old, Pete to this day has the dialect and mannerisms of a true Italian. Surprising, yet true, Pete's ancestry has never caused him to be partial to his native land. America has never had any truer immigrant. Pete expresses his greatest pride when he steps into the bedroom of his two young sons, now gone to war, and says, "The best of me and my America is in this war!"
Computer Enhancement of Evidence Through Background Noise Suppression (1994)

Abstract The use of computers to enhance evidence began more than twenty years ago [1] and first came to the authors' attention in 1977 [2,3], although significant success was achieved through image processing as early as 1974. Today, affordable software packages containing many programs are available. These programs may occasionally be used to advantage on weak or obstructed evidence [4,5]. Various terms have been used to describe these procedures, including “computer enhancement” and “image processing.” An accurate description of these procedures as used by the authors would be “the optimization of signal to noise ratio.” This signal optimization is achieved largely as a result of two factors. First, the digitization of the image affords the operator far greater control over each component of the image than is possible with a photographic (analogue) image. Second, the computer has the ability to discriminate between 256 separate values of gray, from black (0) to white (255), in contrast to approximately 32 separate values perceived by the human eye. Programs of immediate utility, comprising but a small part of the software package, will be described and illustrated.