gebhart/patrepeval huggingface dataset:
The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations (2013)

Bioavailability and clinical effectiveness of a poorly soluble drug can be highly affected by its formulation design. In this respect, research on solid dispersion of hydrophilic carrier has commenced a decade ago to resolve the problem of poorly soluble drug. However, the availability of solid dispersion is commercially limited due to the concerns of its physical instability, unpredictability and inconsistency formulation performance. This is attributed to the lack of fundamental understanding on the processing method, physicochemical properties of the obtained solid dispersion. Therefore, better understanding on the processing methods and factors underlying the performance of solid dispersion may be required to maximize the use of solid dispersion.\nHot melt extrusion (HME) method was introduced in formulating solid dispersion. The use of this production method offers many advantages such as environmental friendly, cost sparing and readily scalable production as compared to conventional methods. On the other hand, the hydrophilic polyvinylpyrrolidone (PVP) polymer with its good stabilising ability in the solid dispersion is less applied in HME process due to its possible degradation at high temperature. However, rejection on the use of PVP without thorough understanding of its potential might lead to underuse of this polymer in HME solid dispersion.\nThis project explores the feasibility of using PVP and its derivative in HME manufacturing method. It offers an in-depth study on the hot melt processing, physical stability and dissolution behaviour of HME PVP-based solid dispersion. Factors affecting the production of fully amorphous solid dispersion and its physical stability are discussed, taking into account the influence of the composition and characteristic of the drug, drug-polymer interaction and the molecular weight of the polymer. In parallel, HME poorly soluble drug in PVP based solid dispersion were produced and investigated for their dissolution performances in order to understand the mechanism underlying the dissolution process of the HME PVP-based solid dispersion system.
Cache consistency and concurrency control in a client/server DBMS architecture (1991)

Article Free Access Share on Cache consistency and concurrency control in a client/server DBMS architecture Authors: Yongdong Wang Computer Science Division-EECS, University of California, Berkeley, CA Computer Science Division-EECS, University of California, Berkeley, CAView Profile , Lawrence A. Rowe Computer Science Division-EECS, University of California, Berkeley, CA Computer Science Division-EECS, University of California, Berkeley, CAView Profile Authors Info & Claims SIGMOD '91: Proceedings of the 1991 ACM SIGMOD international conference on Management of dataApril 1991 Pages 367–376https://doi.org/10.1145/115790.115855Online:01 April 1991Publication History 92citation621DownloadsMetricsTotal Citations92Total Downloads621Last 12 Months40Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Poisson distribution-based page updating prediction strategy (2011)

A kind of method predicting the updating period of page is proposed, using the Poisson distribution-based model suggested by Brewington in studying page updating of search engine. This method calculates the expectation of page updating period with Newton iteration method according to historical statistical data then applies it in the subsequent updating strategy, also revises it in the practice in order to approach the real value; its goal is to get a good balance between freshness and resource utilization. Compared to traditional grouping-by-frequency method, algorithm complexity reduces significantly.
Correction [Book Review] (1992)

Review(s) of: Correction, by M Bartram and R Walton, Language Teaching Publications,1991, $22.95, 122 pp.
Paenibacillus koreensis sp. nov., a new species that produces an iturin-like antifungal compound. (2000)

A bacterial strain, YC300T, that produces an iturin-like antifungal antibiotic was isolated from compost and identified as member of the genus Paenibacillus. Gram reaction of the strain was variable depending upon growth stages and culture media. Three different types of colonies were developed on tryptic soy agar. The organism was facultatively anaerobic and grew at 50 degrees C. The DNA G+C content was 54 mol % and anteiso-C15:0 was the major fatty acid. A 0.9 kb fragment was produced by PCR amplification of strain YC300T DNA using primers PAEN515F and 1377R. Levels of 16S rDNA similarity between strain YC300T and other Paenibacillus species were between 89.8 and 94.8%. Phylogenetically, strain YC300T formed a significant monophyletic clade with Paenibacillus validus. It is clear from polyphasic evidence that the isolate should be classified as Paenibacillus koreensis sp. nov., the type strain of which is YC300T (= KCTC 2393T, KCCM 40903T).
Do mitochondrial DNA fragments promote cancer and aging? (1988)

Reactive oxygen species are important in carcinogenesis, diseases, and aging, probably through oxidative damage of DNA. Our understanding of this relationship at the molecular level is very sketchy. It has recently been found that in mitochondria oxidative DNA damage is particularly high and may not be repaired efficiently. I propose that oxidatively generated DNA fragments escape from mitochondria and become integrated into the nuclear genome. This may transform cells to a cancerous state. Time-dependent nuclear accumulation of mitochondrial DNA fragments may progressively change the nuclear information content and thereby cause aging. This proposal can be tested experimentally.
Distributional Impact of Brain Microbleeds on Global Cognitive Function in Adults Without Neurological Disorder (2012)

This Japanese cross-sectional study demonstrated that MB-related global cognitive dysfunction seems to occur based on hypertensive pathogenesis rather than on cerebral amyloid angiopathy.
Quantitation of Amphotericin B with Use of High-Pressure Liquid Chromatography (1977)

A chemical method for determination of concentrations of amphotericin B in serum and cerebrospinal fluid (CSF) is described. After extraction with methanol, the antibiotic was separated by reverse-phase, high-pressure liquid chromatography and quantitated by absorption at 405 nm. The lower limit of detection of this assay was 0.02 microng/ml. Relative standard deviations of less than 3.6% were noted for multiple determinations of sera containing 0.20 and 1.00 microng of amphotericin B/ml. No interfering peaks were found in extracts of serum or CSF from normal humans or in extracts of serum from patients treated with other drugs and antimicrobial agents, including 5-fluorocytosine. Comparison of the method with microbiological assays showed correlation coefficients of 0.90 and 0.83 for serum and CSF determinations, respectively. This chemical assay is very rapid (less than 30 min), sensitive, accurate, and specific and appears to be suitable for routine clinical use.
Coding Order Decision of B Frames for Rate-Distortion Performance Improvement in Single-View Video and Multiview Video Coding (2010)

The coding gain that can be achieved by improving the coding order of B frames in the H.264/AVC standard is investigated in this work. We first represent the coding order of B frames and their reference frames with a binary tree. We then formulate a recursive equation to find out the binary tree that provides a suboptimal, but very efficient, coding order. The recursive equation is efficiently solved using a dynamic programming method. Furthermore, we extend the coding order improvement technique to the case of multiview video sequences, in which the quadtree representation is used instead of the binary tree representation. Simulation results demonstrate that the proposed algorithm provides significantly better R-D performance than conventional prediction structures.
miR‐181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells (2013)

MicroRNAs are a class of small, endogenous, non-coding RNAs that function as post-transcriptional regulators. In this study, we found that miR-181b promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells. And we validated a new miR-181b target gene, adenylyl cyclase 9 (AC9). miR-181b restricted cAMP production by post-transcriptionally downregulating AC9 expression. Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis.
Emerging Treatment Options in Atopic Dermatitis: Systemic Therapies (2017)

The pathogenesis of atopic dermatitis (AD) is multifactorial and intricate, and the clinical presentation of the condition varies greatly. Symptoms and severity depend on individual trigger factors and stage of the disease. The majority of AD patients are sufficiently treated with emollients in combination with existing topical or systemic therapies. Yet treatment failure with existing drugs and treatment options can be a significant clinical problem. New treatments are under development, and the majority of these new drugs focus on targeting a skewed immune response in AD. Novel therapeutic approaches, which target the pathways involved in the pathogenesis of AD, may provide a potentially more effective and less harmful approach to systemic therapy. These pharmaceutical agents are designed to narrowly modify or directly block a specific cellular signal or pro-inflammatory pathway. We review systemic drugs in the pipeline for AD. To make the review as current and pertinent as possible, we selected to focus on AD-related therapies available in the clinicaltrials.gov database with a first received date after January 1, 2014, up until May 31, 2017. We excluded therapies that could be categorized as either traditional Chinese medicine, herbal medicine, probiotics, histamine/leukotriene blockers, immuno-adsorption, or immunostimulants.
Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b (1997)

Human papillomaviruses (HPVs) are etiologic agents of anogenital cancers. The lack of an efficient in vitro system with which to study the differentiation-dependent viral life cycle has impeded most investigations of viral transcription and gene expression. The CIN-612 clone 9E cell line latently maintains episomal copies of HPV type 31b (HPV31b). The complete replicative life cycle of HPV31b can be studied by using the organotypic (raft) culture system. A number of spliced HPV31b early gene transcripts and two late gene transcripts have been described in studies using the raft system. An HPV31b early promoter, P97, and a differentiation-induced promoter, P742, have been characterized by using this system. In this study, we used the raft system to analyze the temporal expression patterns of HPV31b late gene transcripts during the viral life cycle. The expression of late RNAs peaked at day 12 after lifting to the air-liquid interface; the levels then declined dramatically by day 16. The peak of late RNA expression was coincident with the appearance of virus particles in the raft tissues. We characterized transcripts with the potential to encode late gene products, including 19 RNAs containing the L1 region and 4 RNAs containing the E5b and L2 open reading frames. We also found evidence for two novel promoters. Transcription of both L1- and L2-containing RNAs initiated at a region upstream of the early promoter. In addition, late gene RNAs were also transcribed by using a promoter in the E4 reading frame.
Wavelet domain denoising of single-band and multiband images adapted to the probability of the presence of features of interest (2005)

We study an image denoising approach the core of which is a locally adaptive estimation of the probability that a given coefficient contains a significant noise-free component, which we call "<i>signal of interest</i>". We motivate this approach within the minimum mean squared error criterion and develop and analyze different locally adaptive versions of this method for color and for multispectral images in remote sensing. For color images, we study two different approaches: (i) using a joint spatial/spectral activity indicator in the RGB color space and (ii) componentwise spatially adaptive denoising in a luminance-chrominance space. We demonstrate and discuss the advantages of both of these approaches in different scenarios. We also compare the analyzed method to other recent wavelet domain denoisers for multiband data both on color and on multispectral images.
Social commerce: Looking back and forward (2011)

Abstract Social commerce can be briefly described as commerce activities mediated by social media. In social commerce, people do commerce or intentionally explore commerce opportunities by participating and/or engaging in a collaborative online environment. As a relatively new phenomenon first widely acknowledged in 2005, social commerce presents new opportunities to examine issues related to information/content, business strategies, management, technologies, and people's behavior. This article presents a qualitative longitudinal study which systematically examines technological features and tools in social commerce websites to illustrate their evolution and impacts on the formation of social commerce practice today and its potential future. Using captures crawled by the Wayback Machine, fifteen websites are analyzed from the year they were “born” to the year of 2010. The analyses are guided by a semi‐structured checklist of expected and desired tools and features based on a literature review in social commerce. The study finds that social commerce activities appeared as early as the late 90s and that there are different approaches to incorporating social channels and social networks. In addition, the findings support a preliminary classification of social commerce websites, a realignment of the term's conceptualization and the anticipation of possible new directions for this market segment.
Experimental Demonstration of Feature Extraction and Dimensionality Reduction Using Memristor Networks (2017)

Memristors have been considered as a leading candidate for a number of critical applications ranging from nonvolatile memory to non-Von Neumann computing systems. Feature extraction, which aims to transform input data from a high-dimensional space to a space with fewer dimensions, is an important technique widely used in machine learning and pattern recognition applications. Here, we experimentally demonstrate that memristor arrays can be used to perform principal component analysis, one of the most commonly used feature extraction techniques, through online, unsupervised learning. Using Sanger's rule, that is, the generalized Hebbian algorithm, the principal components were obtained as the memristor conductances in the network after training. The network was then used to analyze sensory data from a standard breast cancer screening database with high classification success rate (97.1%).
Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis (2011)

RSG decreases bone quality. An unusual finding was an increase in cortical bone porosity induced by RSG, consistent with its effect on long bones of women. ALN, an inhibitor of bone resorption, enhanced mechanical strength and may provide an approach to partially counter the deleterious skeletal effects of RSG.
Structural, magnetic, and transport properties of full-Heusler alloy Co2(Cr1−xFex)Al thin films (2004)

The structural, magnetic, and transport properties are investigated for full-Heusler alloy Co2(Cr1−xFex)Al (CCFA) thin films sputtered on thermally oxidized Si substrates at room temperature (RT). X-ray diffraction reveals that the films possess the B2 structure for x=0, decrease the atomic site ordering by substituting Fe for Cr(0.4≦x≦0.6), and form the A2 structure for x=1. Both the magnetic moment and the Curie temperature of the films increase with increasing Fe content (x), although the moment for x&lt;1 is significantly smaller than that of the calculated value for the L21 structure. Magnetic tunnel junctions (MTJs) with CCFA films as either upper or bottom ferromagnetic layers are also fabricated by using metal masks. The maximum tunneling magnetoresistance (TMR) at RT for the MTJ was observed to be 19.1% for x=0.4 with the CCFA film as an upper ferromagnetic layer, despite the atomic disorder of the CCFA film. This is consistent with our previous TMR observation with the CCFA film as a bottom ferromagnetic layer, indicating that the CCFA film even with the B2 structure is a good candidate for future spintronic devices due to its disorder tolerance, high reproducibility, and large spin polarization.
Postnatal Recapitulation of Embryonic Hedgehog Pathway in Response to Skeletal Muscle Ischemia (2003)

Our study shows that the Hh signaling may be recapitulated postnatally in adult and fully differentiated muscular tissues and has a regulatory role on angiogenesis during muscle regeneration after ischemia. These findings demonstrate a novel biological activity for the Hh pathway with both fundamental and potential therapeutic implications.
The generation of ultrashort laser pulses (1983)

Ultrashort laser pulses are finding increasing application in numerous branches of science and technology. This article is an attempt to provide a comprehensive review of the whole field of ultrashort pulse generation, covering both the experimental and the theoretical aspects of the subject. By far the commonest method of generating pulses in the picosecond and subpicosecond regime is the technique known as 'mode-locking' and it is with this that the review is therefore largely concerned. After introductory remarks and a simple treatment of some of the general principles, the central sections of the review deal with the main generic techniques, namely spontaneous mode-locking, active mode-locking (including mode-locking by synchronous pumping) and passive mode-locking. Within each section the material is organised into three main categories, namely (a) general background, (b) historical survey (mainly relating to experimental work and densely packed with references to published work) and (c) theoretical methods (presented with a strongly pedagogical flavour). A major section at the end deals with a mass of important (and mostly recent) work that does not fit naturally into the main framework of the review. This includes USP generation in semiconductor lasers, a number of special methods such as injection mode-locking (and others where two or more mode-locking techniques are combined), as well as chopping and switching techniques.
<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">R</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Fe</mml:mi></mml:mrow><mml:mrow><mml:mn>14</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>B materials: Intrinsic properties and technological aspects (1991)

Magnetic materials research has entered a new and exciting period with the advent of the ternary rare-earth-iron-boron compounds, ${\mathrm{R}}_{2}$${\mathrm{Fe}}_{14}$B. From the fundamental physics perspective the ${\mathrm{R}}_{2}$${\mathrm{Fe}}_{14}$B series and its isostructural relatives comprise a rich, fascinating area for the investigation of many intrinsic properties, including magnetic structures, magnetocrystalline anisotropy, and rare-earth-transition-metal exchange interactions. Intense interest in the technological aspects of these compounds has been ignited by the fact that energy products eclipsing all previous values have been realized in practical magnets based on ${\mathrm{Nd}}_{2}$${\mathrm{Fe}}_{14}$B, the prototypical representative; these magnets also feature economic advantages over the earlier samarium-cobalt materials. Both facets of the ${\mathrm{R}}_{2}$${\mathrm{Fe}}_{14}$B systems are considered in this review.
Energy loss via urine and faeces – a combustive analysis in diabetic rats and the impact of antidiabetic treatment on body weight (2012)

Our data clearly show renal contribution to the body's energy control by urinary glucose excretion (UGE) during antidiabetic treatment. The undesired retained energy could be reduced via additional UGE or via simultaneous reduction of energy uptake and/or energy retention.
A stochastic learning based approach for automatic medical diagnosis using HMM toolbox in scilab environment (2005)

In this work, automatic medical diagnosis system of sleep apnea syndrome is presented. This system is based on hidden Markov models (HMMs) Scilab toolbox. Conventional as well as a new simulated annealing based approaches to train HMMs are incorporated. The inference method of this system translates event state value into common interpretation as a pathophysiological state. The interpretation is extended to sequences of states in time to obtain a pathophysiological state-space trajectory. Some of the measurements of the respiratory activity issued by the technique of polysomnography are considered for offline or online detection of different sleep apnea syndromes. Experimental results using respiratory clinical data and some future perspectives of our work are presented
Expression of sialyl 6-sulfo Lewis X is inversely correlated with conventional sialyl Lewis X expression in human colorectal cancer. (2000)

Sialyl 6-sulfo Lewis X determinant has been described recently as a major ligand for L-selectin on high endothelial venules of human peripheral lymph nodes. From our investigation of its distribution in human colorectal cancer tissues and cultured colon cancer cells, the sialyl 6-sulfo Lewis X determinant was preferentially expressed in the nonmalignant colonic epithelia rather than cancer cells (P < 0.001; n = 23). This was in contrast to the distribution of conventional sialyl Lewis X, which was preferentially expressed in cancer tissues rather than nonmalignant epithelia (P = 0.007; n = 23), indicating that 6-sulfation predominantly occurs in nonmalignant tissues and is suppressed upon malignant transformation. In confirmation of this, a nonsialylated determinant 6-sulfo Lewis X was also found to be preferentially localized in the nonmalignant epithelia. Significant expression of sialyl 6-sulfo Lewis X was observed in only 2 lines, whereas 8 were positive for conventional sialyl Lewis X, among 13 cultured colon cancer cell lines. Transfection of cells with fucosyltransferase (Fuc-T) VI induced expression of sialyl 6-sulfo Lewis X, whereas transfection of Fuc-T III did not, suggesting that the determinant was synthesized mainly by Fuc-T VI in colonic epithelia. Members of the sialic acid cyclase pathway, the de-N-acetyl sialyl 6-sulfo Lewis X and cyclic sialyl 6-sulfo Lewis X determinants, were also preferentially expressed in the nonmalignant epithelia rather than colonic cancer cells (P < 0.001; n = 23). Stimulation of the sialyl 6-sulfo Lewis X-positive colon cancer cell line with a calcium ionophore ionomycin markedly reduced sialyl 6-sulfo Lewis X and induced cyclic sialyl 6-sulfo Lewis X expression. These results suggested that the metabolic conversion of sialyl 6-sulfo Lewis X into cyclic sialyl 6-sulfo Lewis X by a calcium-dependent enzyme, sialic acid cyclase, as we hypothesized for human leukocytes previously (C. Mitsuoka et al., Proc. Natl. Acad. Sci. USA, 96: 1597-1602, 1999), also occurs in nonmalignant colonic epithelia.