gebhart/patrepeval huggingface dataset:
A comparison of the carotenoid accumulation in Capsicum varieties that show different ripening colours: deletion of the capsanthin-capsorubin synthase gene is not a prerequisite for the formation of a yellow pepper (2007)

Ripe pepper (Capsicum sp.) fruits can display a range of colours from white to deep red. To understand better the regulatory mechanisms of the carotenoid biosynthetic pathways that underlie these ripening colours, Capsicum varieties that show seven different fully ripe colour types were analysed. The levels and composition of the carotenoid accumulation in these samples at different stages of ripening were measured, and the resulting data were analysed in conjunction with the expression patterns of the carotenoid biosynthetic genes. It was found that red peppers accumulate increasing levels of total carotenoids during ripening, whereas non-red peppers accumulate lower levels of total carotenoids of varying composition. The expression levels of the phytoene synthase, phytoene desaturase, and capsanthin-capsorubin synthase (Ccs) genes are high in peppers with high levels of total carotenoid, whereas one or two of these genes are not expressed in peppers with lower levels of total carotenoid. Surprisingly, it was found that the Ccs gene is present in two Capsicum varieties whose ripe colour is yellow. This gene has never previously been shown to be present in yellow peppers. Sequence analyses of the Ccs gene further revealed two structural mutations in yellow peppers that may result in either a premature stop-codon or a frame-shift. Taken together with the fact that the Ccs transcript is not detectable in yellow peppers, our current results suggest that nonsense-mediated transcriptional gene silencing of Ccs and not the deletion of this gene is responsible for yellow ripening in Capsicum.
Reduced-dimension beam-space broad-band source localization: preprocessor design and evaluation (2003)

A beam-space processor structure is described that reduces the data from element-space to a reduced-dimension beam-space while focusing broadband sources that are within the selected location sector. The objective is principally to reduce the data observation dimension, thereby reducing computation in subsequent source location estimation and focusing sources within the sector. Additional advantages include: spatial filtering to eliminate multiple source cluster processing; improved spectral resolvability relative to element space processing; and reduced sensitivity to assumed noise characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Applications For A High Capacity, High Data Rate Optical Disk Buffer (1988)

A high performance Optical Disk Buffer concept for Terabit storage and Gigabit/s data rate is being developed along modular lines, such that additional new configurations for specific applications are evolving. This paper describes progress in the development of the basic modular subsystems, and correlates the modular performance with an extended family of Optical Disk Buffer configurations and system applications.
5-Hydroxytryptamine 2C (5-HT<sub>2C</sub>) Receptor Agonists as Potential Antiobesity Agents (2006)

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXT5-Hydroxytryptamine 2C (5-HT2C) Receptor Agonists as Potential Antiobesity AgentsBjörn M. NilssonView Author Information Biovitrum AB, SE-112 76 Stockholm, Sweden Cite this: J. Med. Chem. 2006, 49, 14, 4023–4034Publication Date (Web):June 17, 2006Publication History Received16 June 2005Published online17 June 2006Published inissue 1 July 2006https://pubs.acs.org/doi/10.1021/jm058240ihttps://doi.org/10.1021/jm058240ireview-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views1394Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Food,Receptors,Rodent models,Selectivity Get e-Alerts
<i>Helicobacter pylori</i> and non‐<i>Helicobacter pylori</i> bacterial flora in gastric mucosal and tumour specimens of patients with primary gastric lymphoma (1997)

There is an association between Helicobacter pylori (H. pylori) and gastric mucosa-associated lymphoid tissue (MALT) and MALT lymphoma. Histologically, mainly non-specific stains are used to detect H. pylori, such as haematoxylin-eosin (HE) or modified Giemsa (MG). In this study, both a MG and a specific immunohistochemical stain (IMM) for H. pylori (Dako B471) were performed on sequential slides of resected material containing tumour and non-tumorous gastric mucosa from patients with primary gastric lymphoma (n = 52). Special attention was paid to the presence of non-H. pylori bacterial flora diagnosed by a positive MG (according to form and localization) and a subsequently negative IMM. On all slides, bacterial density was scored semiquantitatively (grades 0, 1, 2, 3). In total, 32 (61.5%) patients were H. pylori positive using IMM and 34 (65.4%) were non-H. pylori positive using MG. In 24 out of the 34 patients, the non-H. pylori flora consisted mainly of cocci in combination with rods in 15 patients, mostly in minor quantities; in another 10 patients, high numbers of both cocci and different types of rods were present. Most non-H. pylori bacteria were localized superficially, although in 22 patients minor quantities of non-H. pylori were also seen in the glandular lumina. After all of the patients had been analysed, no differences in the density of H. pylori and of non-H. pylori flora were found. Only when comparing patients who had a small-cell lymphoma with those who had a large-cell lymphoma was a significantly higher density of H. pylori found in the corpus mucosa of large-cell lymphomas and a higher prevalence of non-H. pylori was found in tumours, in antrum or corpus, of patients with large-cell lymphomas. In conclusion, with joint evaluation using MG and a H. pylori-specific immunohistochemical stains, the proportion of H. pylori-positive gastric lymphoma patients was lower than in most previous studies but other bacteria were found in a relatively high proportion. The role of the non-H. pylori intragastric bacterial flora identified in this study has to be further elucidated in the aetiopathogenesis of primary gastric lymphoma.
Advantages of SiGe-pnp over Si-pnp for analog and RF enhanced CBiCMOS and Complementary Bipolar design usage (2016)

The evolution of silicon and silicon-germanium pnp transistors is reviewed in this paper. The motivation for SiGe-pnp transistors in Complementary Bipolar (CBi) and CBiCMOS is discussed with a view on device parametric parameters that help gage the usefulness of these devices in analog and RF design. We review the basic process architectures and process building blocks for CBiCMOS. SiGe-pnp versus Si-pnp performance metrics are highlighted followed by a discussion on circuit blocks that benefit from having near matched complementary bipolar transistors.
214. Reactions of nitriles. Part I. Condensation of methyleneaminoacetonitrile with aldehydes (1961)

D. D. Vaghani and J. R. Merchant, J. Chem. Soc., 1961, 1066 DOI: 10.1039/JR9610001066
Reactions in the System TiO <sub>2</sub> ‐P <sub>2</sub> O <sub>5</sub> (1959)

The system TiO 2 ‐P 2 O 5 was investigated in the compositional range TiO 2 .P 2 O 5 to 100% TiO 2 . Two compounds exist, TiO 2 .P 2 O 5 and 5TiO 2 .‐2P 2 O 5 . TiO 2 .P 2 O 5 begins to lose P 2 O 5 at 1400°C. and both fusion and vaporization proceed rapidly at 1500°C. 5TiO 2 .2P 2 O 6 melts congruently at 1260°± 3°C. to a glass which can be retained in substantial quantities at room temperature. Physical properties of certain compositions are described.
A retrospective review of basilic and cephalic vein-based fistulas (2011)

This study compares outcomes of basilic and cephalic vein fistulas for hemodialysis. A retrospective review of arteriovenous fistulas in a university hospital system was performed using charts and hemodialysis records. Patency and demographic data were assessed with life table analysis. One hundred fifty-six patients (88 males; 68 females) underwent creation of 172 autogenous fistulas (mean age 61 years; mean follow-up 78 weeks). There were 101 basilic vein transpositions and 71 cephalic vein fistulas. Primary patency did not differ significantly, while assisted primary patency was significantly better for basilic vein fistulas at one year (73% versus 53%: P = 0.024). Secondary patency was significantly better for basilic fistulas through three years (58% versus 52%; P = 0.027). Primary failure (thrombosis before access or failed maturation) was significantly higher for cephalic than basilic fistulas (28% versus 13%; P = 0.01). Maturation time, usage time and complications were not significantly significant. Thirty-three (33%) basilic vein-based fistulas and 12 (17%) cephalic vein fistulas required revision during follow-up. Basilic vein-based fistulas perform as well as or better than cephalic vein-based fistulas in terms of patency, maturation time, and usage time and complication rates, though requiring more re-interventions.
ChemInform Abstract: Process and Film Characterization of Chemical‐Bath‐Deposited ZnS Thin Films. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity* (2004)

Apoptosis of circulating neutrophils from patients with clinical sepsis is profoundly suppressed, through a mechanism that involves activation of nuclear factor-kappaB that is associated with reduced activity of caspases-9 and -3 and maintenance of mitochondrial transmembrane potential and that differs in important respects from the inhibitory effects seen following the exposure of healthy neutrophils to inflammatory stimuli.
Development and assessment of methods for detecting dementia using the human electroencephalogram (2006)

This paper makes an outline case for the need for a low-cost, easy to administer method for detecting dementia within the growing at risk population. It proposes two methods for electroencephalogram (EEG) analysis for detecting dementia that could fulfil such a need. The paper describes a fractal dimension-based method for analyzing the EEG waveforms of subjects with dementia and reports on an assessment which demonstrates that an appropriate fractal dimension measure could achieve 67% sensitivity to probable Alzheimer's disease (as suggested by clinical psychometric testing and EEG findings) with a specificity of 99.9%. An alternative method based on the probability density function of the zero-crossing intervals is shown to achieve 78% sensitivity to probable Alzheimer's disease and an estimated sensitivity to probable Vascular (or mixed) dementia of 35% (as suggested by clinical psychometric testing and EEG findings) with a specificity of 99.9%. This compares well with other studies, reported by the American Academy of Neurology, which typically provide a sensitivity of 81% and specificity of 70%. The EEG recordings used to assess these methods included artefacts and had no a priori selection of elements "suitable for analysis." This approach gives a good prediction of the usefulness of the methods, as they would be used in practice. A total of 39 patients (30 probable Alzheimer's Disease, six Vascular Dementia and three mixed dementia) and 42 healthy volunteers were involved in the study. However, although results from the preliminary evaluation of the methods are promising, there is a need for a more extensive study to validate the methods using EEGs from a larger and more varied patient cohorts with neuroimaging results, to exclude other causes and cognitive scores to correlate results with severity of cognitive status.
Damages for Pre-Contract Expenditure (1972)

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CRASHWORTHINESS ANALYSIS AND DESIGN USING RIGID-FLEXIBLE MULTIBODY DYNAMICS WITH APPLICATION TO TRAIN VEHICLES (1997)

Different formulations based on multibody dynamics are shown to be suitable for the development of a methodology for the impact simulation and crashworthiness design of railway vehicles. The proposed design methodology comprises different computer-aided tools of increasing complexity and accuracy which can be used with greater advantage and efficiency in the different design stages of railway stock. In general, the crashworthiness design methods and associated multibody dynamic tools which are presented in this paper require information to be obtained from numerical or experimental crush tests of specific structural components, subassemblies and critical energy absorption devices normally located in car extremities. This hybrid feature lends to the present design process various efficiency gains as a result of a better understanding of the crash and different collapse mechanisms and ease of use. To access the merits of the present methodologies some new designs are discussed and the application of the proposed numerical tools is illustrated for different structural configurations of car extremities. A formulation for the sensitivity analysis and optimization of planar constrained mechanical systems is also presented. An example of crashworthiness design of an end underframe model of a railway car is solved to demonstrate the use of the methodology. © 1997 by John Wiley & Sons, Ltd.
Multi‐Alternating Organic Semiconducting Films with High Electric Conductivity (2014)

High electric conductivity is observed in multilayer stack of m‐MTDATA/F 16 CuPc. Impedance data shows that the circuit resistance is significantly dropped by three orders of magnitude from ∼0.2 MΩ to ∼0.4 kΩ when the number of alternating units is increased from one to six, keeping a total thickness of 300 nm. Impedance results show that as the number of alternating units increases, the organic stack shows an increasing capacitance and a decreasing resistance. This result suggests the increasing charges accumulate at the heterojunctions, leading to reduction in overall film resistance. The application of the high conductive units in OLED device results in stability enhancement.
Genes coding for the elongation factor EF‐1<sub>α</sub> in <i>Artemia</i> (1986)

The elongation factor EF-1 alpha is one of the most abundant proteins in eukaryotic cells, where it catalyzes the binding of aminoacyl-tRNA to ribosomes. The genes coding for this protein in the brine shrimp Artemia were analyzed by gene cloning, electron microscopy and chromosomal blot hybridization. There are only a few (about four) copies of one type of gene per haploid genome. These genes contain five exons divided over 10(4) base pairs. Local rearrangements give rise to a number of gene variants. Cross-hybridizations of Artemia cDNA probes with yeast and Drosophila DNA revealed two different yeast EF-1 alpha genes and one or two different Drosophila genes, respectively. Nucleotide sequencing revealed signals for synthesis and processing of EF-1 alpha transcripts as well as the exact location of exons. One interruption in the coding sequence corresponds closely to a splice junction in the gene coding for the homologous chloroplast protein EF-Tu from Euglena gracilis, presumably of prokaryotic origin. The first exon in the chloroplast gene codes for the region of EF-Tu that is homologous to regions of the elongation factor EF-G and of the initiation factor IF2, respectively.
Total Syntheses of (+)- and (−)-Peribysin E (2008)

A convergent, stereocontrolled route to either antipode of the cell adhesion inhibitor, peribysin E, has been achieved from carvone. Highlights of the synthesis include a Diels-Alder reaction to generate a cis-decalin framework, followed by semipinacol-type ring contraction to secure the stereochemistry of the C7 quaternary center. Potential mechanistic pathways for the critical ring contraction were studied through deuterium incorporation studies. In addition, an optimized olefin isomerization/Saegusa oxidation protocol is described for the conversion of [4+2] cycloadducts of 2-(trialkylsilyloxy)-1,3-dienes to 1,6(2H,7H)-naphthalenediones, having stereochemical arrangements not accessible via conventional Robinson annulation protocols. Finally, the ability to independently prepare either enantiomer of peribysin E from the corresponding antipode of carvone led to a reassignment of the absolute configuration of peribysin E.
Packaging of Implantable Microsystems (2007)

Challenges and technologies for long-term stable packaging of implantable devices and microsystems are reviewed. Packaging of implantable microsystems is especially difficult because of the many limitations in terms of size, material properties, mechanical structure and rigidity, biocompatibility, required lifetime, and maximum allowable temperature. Our group has demonstrated their long-term reliability in salt water and biological environments. Glass packages anodically bonded to silicon substrates containing integrated sensors/circuits provide a mean-time-to-failure (MTTF) of >100 years in saline solutions under accelerated conditions, and a lifetime of almost two years in biological tissue1. Thin film coatings of electroplated gold have also been used for packaging of implantable microprobes and shown to be hermetic under accelerated conditions and provide a MTTF of ~40 years. Polymer films, such as Parylene, are of particular interest for many biomedical microsystems because of their flexibility and ease of use. Long-term testing of passive implantable sensors using these films has also been demonstrated.
PcrA Helicase Tightly Couples ATP Hydrolysis to Unwinding Double-Stranded DNA, Modulated by the Initiator Protein for Plasmid Replication, RepD (2009)

The plasmid replication initiator protein, RepD, greatly stimulates the ability of the DNA helicase, PcrA, to unwind plasmid lengths of DNA. Unwinding begins at oriD, the double-stranded origin of replication that RepD recognizes and covalently binds to initiate replication. Using a combination of plasmids containing oriD and oligonucleotide structures that mimic parts of oriD, the kinetics of DNA nicking and separation have been determined, along with the coupling ratio between base separation and ATP hydrolysis. At 30 degrees C, the rate of nicking is 1.0 s(-1), and translocation is approximately 30 bp s(-1). During translocation, the coupling ratio is one ATP hydrolyzed per base pair separated, the same as the value previously reported for ATP hydrolyzed per base moved by PcrA along single-stranded DNA. The data suggest that processivity is high, such that several thousand base-pair plasmids are unwound by a single molecule of PcrA. In the absence of RepD, a single PcrA is unable to separate even short lengths (10 to 40 bp) of double stranded DNA.
Characterization of Specific Nucleotide Substitutions in DtxR-Specific Operators of <i>Corynebacterium diphtheriae</i> That Dramatically Affect DtxR Binding, Operator Function, and Promoter Strength (2000)

The diphtheria toxin repressor (DtxR) of Corynebacterium diphtheriae uses Fe(2+) as a corepressor. Holo-DtxR inhibits transcription from the iron-regulated promoters (IRPs) designated IRP1 through IRP5 as well as from the promoters for the tox and hmuO genes. DtxR binds to 19-bp operators with the consensus sequence 5'-TTAGGTTAGCCTAACCTAA-3', a perfect 9-bp palindrome interrupted by a single C. G base pair. Among the seven known DtxR-specific operators, IRP3 exhibits the weakest binding to DtxR. The message (sense) strand of the IRP3 operator (5'-TTAGGTGAGACGCACCCAT-3' [nonconsensus nucleotides underlined]) overlaps by 2 nucleotides at its 5' end with the putative -10 sequence of the IRP3 promoter. The underlined C at position +7 from the center of the IRP3 operator [C(+7)] is unique, because T is conserved at that position in other DtxR-specific operators. The present study examined the effects of nucleotide substitutions at position +7 or -7 in the IRP3 operator. In gel mobility shift assays, only the change of C(+7) to the consensus nucleotide T caused a dramatic increase in the binding of DtxR, whereas other nucleotide substitutions for C(+7) or replacements for A(-7) had only small positive or negative effects on DtxR binding. All substitutions for C(+7) or A(-7) except for A(-7)C dramatically decreased IRP3 promoter strength. In contrast, the A(-7)C variant caused increased promoter strength at the cost of nearly eliminating repressibility by DtxR. The message (sense) strand of the IRP1 operator (5'-TTAGGTTAGCCAAACCTTT-3') includes the -35 region of the IRP3 promoter. A T(+7)C variant of the IRP1 operator was also constructed, and it was shown to exhibit decreased binding to DtxR, decreased repressibility by DtxR, and increased promoter strength. The nucleotides at positions +7 and -7 in DtxR-specific operators are therefore important determinants of DtxR binding and repressibility of transcription by DtxR, and they also have significant effects on promoter activity for IRP3 and IRP1.
Seismic stimulation for enhanced oil recovery (2008)

Abstract The pore-scale effects of seismic stimulation on two-phase flow are modeled numerically in random 2D grain-pack geometries. Seismic stimulation aims to enhance oil production by sending seismic waves across a reservoir to liberate immobile patches of oil. For seismic amplitudes above a well-defined (analytically expressed) dimensionless criterion, the force perturbation associated with the waves indeed can liberate oil trapped on capillary barriers and get it flowing again under the background pressure gradient. Subsequent coalescence of the freed oil droplets acts to enhance oil movement further because longer bubbles overcome capillary barriers more efficiently than shorter bubbles do. Poroelasticity theory defines the effective force that a seismic wave adds to the background fluid-pressure gradient. The lattice-Boltzmann model in two dimensions is used to perform pore-scale numerical simulations. Dimensionless numbers (groups of material and force parameters) involved in seismic stimulation were defined carefully so that numerical simulations could be applied to field-scale conditions. Using defined analytical criteria, there is a significant range of reservoir conditions over which seismic stimulation can be expected to enhance oil production.
Water pollution monitoring system based on Zigbee wireless sensor network (2011)

A water pollution monitoring system based on zigbee wireless sensor network is proposed aiming at current severe situation of global water pollution. The network node hardware circuit of this proposal specifically lays out the hardware and software design of the network node, with JN5130 CMOS chip producing by Jennie company as core. Low-cost, low-consumption and easy-expansion, the system could inspect the water pollution level timely, which provides important proofs for related departments to make decisions.