gebhart/patrepeval huggingface dataset:
Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients (2017)

Changes in thermograms observed in the disease state likely reflect covalent modifications of plasma proteins or changes in large protein-protein interacting networks resulting in the stabilization of plasma proteins towards thermal denaturation. By relating functional principal components from thermograms to disease status, our Functional Principal Component Analysis model provides results that are more easily interpretable compared to prior studies. Further, the model could also potentially be coupled with other biomarkers to improve diagnostic classification for lupus.
The use of 212Pb-labeled monoclonal antibody in the treatment of murine erythroleukemia (1996)

An effective, nonlethal dose could not be established to treat this tumor. The severe bone marrow toxicity associated with this radionuclide may limit its usefulness in systemic radioimmunotherapy.
Genetic parameters and selection strategies for soybean genotypes resistant to the stink bug-complex (2009)

Soybean genotypes resistant to stink bugs are derived from complex breeding processes obtained through indirect selection. The aim of the present work was to estimate genetic parameters for guiding selection strategies towards resistant genotypes, based on those traits associated with responses to pod-attacking stink bugs, such as the grain filling period (GFP), leaf retention (LR), percentage index of pod damage (PIPD) and percentage of spotted seeds (PSS). We assessed the parental lines IAC-100 (resistant) and FT-Estrela (susceptible), the progenies F(2) and F (4) , 30 progenies F (2:3) , 30 progenies BC (1) F (2:3) and 30 progenies BC (2) F (2:3) , besides the cultivars BRS Celeste and MGBR-46 (Conquista). Three field experiments, using randomized complete block design with three replications, were installed in Goiânia-GO, in the 2002/03 season. Each experiment consisted of 36 treatments (6 common and 30 regular). Heritability estimates were: 74.6 and 36.1 (GFP); 51.9 and 19.9 (LR); 49.6 and 49.6 (PIPD) and 55.8 and 20.3 (PSS), in both the broad and narrow senses, respectively. Based on these results, we concluded that the best strategy for obtaining stink bug-resistant genotypes consists of selecting the PIPD trait in early generations (F (3) or F (4) ), followed by selection for the GFP, LR and PSS traits in generations with higher endogamy levels.
Geostatistical History Matching Using a Regional Probability Perturbation Method (2003)

Abstract Petroleum reservoirs are large, geologically complex and usually contain multiple wells. Building numerical models for reservoirs is not a simple task, and it is further complicated when production data is incorporated into the reservoir models. Integrating production data into the model requires an iterative process of changing the model and observing how those changes effect the flow of fluids in the model. This process should be as efficient as possible because each iteration requires a time-consuming flow simulation, and it should honor all available data so that the predictive models are as accurate as possible. This paper lays out a general procedure for modifying geostatistical realizations in a geologically consistent manner that efficiently matches production data. To achieve this goal various regions in the reservoir are perturbed by different amounts, yet no geological artifacts are created at the borders of these regions. The methodology relies on a region-wise perturbation of the probability model used to generate the geostatistical realization. Perturbing probabilities rather than actual petrophysical properties guarantees that border artifacts are avoided. A new, simple yet efficient optimization method is developed that can jointly optimize the magnitude of the perturbations and is able to handle a large number of regions. We demonstrate with realistic synthetic examples that the method allows perturbing under various geological scenarios, and a 3D realistic synthetic case of a North Sea fluvial channel type reservoir demonstrates how the method would work in practice.
Through-Wall Human Mesh Recovery Using Radio Signals (2019)

This paper presents RF-Avatar, a neural network model that can estimate 3D meshes of the human body in the presence of occlusions, baggy clothes, and bad lighting conditions. We leverage that radio frequency (RF) signals in the WiFi range traverse clothes and occlusions and bounce off the human body. Our model parses such radio signals and recovers 3D body meshes. Our meshes are dynamic and smoothly track the movements of the corresponding people. Further, our model works both in single and multi-person scenarios. Inferring body meshes from radio signals is a highly under-constrained problem. Our model deals with this challenge using: 1) a combination of strong and weak supervision, 2) a multi-headed self-attention mechanism that attends differently to temporal information in the radio signal, and 3) an adversarially trained temporal discriminator that imposes a prior on the dynamics of human motion. Our results show that RF-Avatar accurately recovers dynamic 3D meshes in the presence of occlusions, baggy clothes, bad lighting conditions, and even through walls.
Box and Block Test of Manual Dexterity: Norms for 6–19 Year Olds (1985)

The purpose of this study was to collect normative data for individuals, aged 6 to 19 years, on the Box and Block test of manual dexterity. Four hundred and seventy-one subjects (231 females and 240 males) were recruited from the seven county Milwaukee area. The subjects were from urban, suburban, and rural settings thus encompassing a wide range of socioeconomic backgrounds. Data were stratified into seven age groups of two year intervals. Results showed that increases in manual dexterity coincided with increases in chronological age. Female scores were generally better from 6 to 11 years, while males achieved slightly higher scores from 12 to 19 years. On the average right and left hand dominant subjects scored higher with their right hands although right handers were clearly more lateralized than left handers.
Pulpal blood flow in vital and nonvital young permanent teeth measured by transmitted-light photoplethysmography: a pilot study. (2003)

TLP can detect pulpal blood flow in young permanent teeth. This technique is considered to be applicable in the assessment of pulp vitality.
Increased Oxidative Damage with Altered Antioxidative Status in Type 2 Diabetic Patients Harboring the 16189 T to C Variant of Mitochondrial DNA (2005)

A transition of T to C at nucleotide position 16189 in mitochondrial DNA (mtDNA) has attracted biomedical researchers for its probable correlation with the development of diabetes mellitus in adult life. In diabetes, persistent hyperglycemia may cause high production of free radicals. Reactive oxygen species are thought to play a role in a variety of physiologic and pathophysiologic processes in which increased oxidative stress may play an important role in disease mechanisms. The aim of the present study was to clarify the degree of oxidative damage and plasma antioxidant status in diabetic patients and to see the potential influence of the 16189 variant of mtDNA on the oxidative status in these patients. An indicative parameter of lipid peroxidation, malondialdehyde (MDA), and total free thiols were measured from plasma samples of 165 type 2 diabetic patients with or without this variant and 168 normal subjects. Here we report an increase in the plasma levels of MDA and total thiols in type 2 diabetic patients compared with control subjects. The levels of plasma thiols in diabetic patients with the 16189 variant of mtDNA were not different from those in controls. These results suggest an increase in the oxidative damage and a compensatory higher antioxidative status in patients with type 2 diabetes. Harboring the 16189 mtDNA variant may impair the ability of a cell to respond properly to oxidative stress and oxidative damage.
Enhanced Luminescence of Lanthanide(III) Complexes in Polymer Matrices (1999)

Abstract Effectively luminescent organic polymers were successfully fabricated by incorporating deuterated hexafluoroacetylacetonato Nd(III) or Eu(III) complex and DMSO-d6 in polyalkylmethacrylate matrices with low percentage of H atoms.
First-Principles Calculation of the Magnetic Anisotropy Energies of Ag/Fe(001) and Au/Fe(001) Multilayers (1996)

The anisotropy energies of (111) and (001) oriented Ag/Fe and Au/Fe multilayers are obtained by a first-principle calculation to investigate the orientational dependence of the magnetic anisotropy. All systems show perpendicular anisotropy in good agreement with experiments. In the case of Ag/Fe multilayers, the anisotorpy energy of the (001) oriented multilayer is larger than that of the (111) multilayer. In contrast to Ag/Fe, Au/Fe(111) multilayer exhibits a stronger perpendicular anisotropy than the (001) oriented system. In all systems, a large minority-spin LDOS of | m | =2 character of Fe near the Fermi energy could be the origin of perpendicular magnetic anisotropy.
Fabrication and characterization of germanium-on-silicon photodiodes (2012)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.
Construction of specific cosmids from YACs by homologous recombination in yeast (1995)

Journal Article Construction of specific cosmids from YACs by homologous recombination in yeast Get access Laura B. K. Herzing, Laura B. K. Herzing CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer ResearchFulham Road, London SW3 6JB, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan Ashworth Alan Ashworth * CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer ResearchFulham Road, London SW3 6JB, UK * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 23, Issue 19, 11 October 1995, Pages 4005–4006, https://doi.org/10.1093/nar/23.19.4005 Published: 11 October 1995 Article history Received: 26 July 1995 Revision received: 04 September 1995 Accepted: 04 September 1995 Published: 11 October 1995
Defining target antigens for CD25<sup>+</sup>FOXP3<sup>+</sup>IFN‐<i>γ</i><sup>−</sup> regulatory T cells in chronic hepatitis C virus infection (2007)

The mechanism behind the apparent lack of effective antiviral immune responses in chronic hepatitis C virus (HCV) patients is poorly understood. It remains unclear if natural regulatory T cells (Treg) contribute to the induction and maintenance of HCV persistence. We herein report for the first time that CD25(high)IFN-gamma(-)FOXP3(high) Tregs can be rapidly induced by culturing peripheral blood mononuclear cells (PBMCs) of HCV-positive patients with HCV protein-derived peptides. The HCV-specific Tregs, generally CD4(+)CD45RO(+), did not proliferate in response to HCV peptide and failed to produce interferon (IFN)-gamma, in distinct contrast to antiviral effector cells. Stimulation of healthy donor PBMCs with HCV peptides did not result in CD25 and FOXP3 upregulation above non-antigen background. To further investigate the antigen specificity of these potentially disease-associated natural Tregs, CD25(+) cells were isolated from PBMCs, labeled with carboxyfluorescein diacetate succinimidylester and added back to CD25-depleted PBMCs, and the co-cultures were then stimulated with individual peptides derived from the HCV core protein. We found that the actual peptide that can stimulate Treg varied between patients, but within any given subject only a small number of the peptides were able to stimulate Treg, suggesting the existence of dominant Treg epitopes. Although functional experiments for these peptides are ongoing in our laboratory, data presented here suggests that HCV-specific natural Tregs are abundant in infected individuals, in contrast to the extremely low frequency of anti-HCV effector T cells, supporting the view that natural Treg may be implicated in host immune tolerance during HCV infection.
LASIK Surgery (2000)

The laser in situ keratomileusis (i.e., LASIK) procedure reshapes the surface of the cornea to focus visual images directly onto the retina, thereby improving visual acuity. In 1998, approximately 420,000 LASIK procedures were performed in the United States, and approximately two million people throughout the world already are benefiting from the LASIK vision correction procedure.
<b>Germination‐related genes encoding proteolytic enzymes are expressed in the nucellus of developing wheat grains</b> (1998)

Summary During wheat ( Triticum aestivum ) grain germination the aleurone layer shows a high expression of genes encoding hydrolytic enzymes. In this study we analyzed the spatio‐temporal pattern of expression of two of these genes, a carboxypeptidase III and a thiol protease, in developing grains. Our results show that transcripts of both genes accumulate at early stages of grain development (5–15 dpa) in the nucellus, a maternal tissue that degenerates during wheat grain development. In addition, the thiol protease gene is expressed in the nucellar projections and the modified aleurone cells, the cellular pathway of photosynthate transfer in the developing wheat grain. These results show that genes related to the germination programme are also expressed in the development programme where they may be implicated in the degenerative process that takes place in the nucellar tissue and the cytoplasm of nucellar projections cells.
Systemic Signaling and Acclimation in Response to Excess Excitation Energy in <i>Arabidopsis</i> (1999)

Land plants are sessile and have developed sophisticated mechanisms that allow for both immediate and acclimatory responses to changing environments. Partial exposure of low light-adapted Arabidopsis plants to excess light results in a systemic acclimation to excess excitation energy and consequent photooxidative stress in unexposed leaves. Thus, plants possess a mechanism to communicate excess excitation energy systemically, allowing them to mount a defense against further episodes of such stress. Systemic redox changes in the proximity of photosystem II, hydrogen peroxide, and the induction of antioxidant defenses are key determinants of this mechanism of systemic acquired acclimation.
Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation (2014)

Sox4 expression is restricted in mammals to embryonic structures and some adult tissues, such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 regulates mesenchymal and neural progenitor survival, as well as lymphocyte and myeloid differentiation, and contributes to pancreas, bone, and heart development. Aberrant Sox4 expression is linked to malignant transformation and metastasis in several types of cancer. To understand the role of Sox4 in the adult organism, we first generated mice with reduced whole-body Sox4 expression. These mice display accelerated aging and reduced cancer incidence. To specifically address a role for Sox4 in adult stem cells, we conditionally deleted Sox4 (Sox4(cKO)) in stratified epithelia. Sox4(cKO) mice show increased skin stem cell quiescence and resistance to chemical carcinogenesis concomitantly with downregulation of cell cycle, DNA repair, and activated hair follicle stem cell pathways. Altogether, these findings highlight the importance of Sox4 in regulating adult tissue homeostasis and cancer.
The cascade CLOS broadcast switching network - a new atm switching network which is multiconnection non-blocking (2005)

We present a new multiconnection ATM switching network, called the Cascade Clos Broadcast Switching Network (CC8 SY). It has the following features. Firstly, the CCB-SM is son blocking for multiconnection. Therefore, deterioration of traffic handling performance due to anon-uniform traffic pattern does not occur. Secondly, In the CCB-SM, the cells are replicated after they are partly routed. And so, the delay time caused by the increment of replicas of cells is kept to a minimum.
High Hydrostatic Pressure Can Reverse Aggregation of Protein Folding Intermediates and Facilitate Acquisition of Native Structure (1998)

The present work demonstrates that high hydrostatic pressure can increase protein folding by reducing nonspecific aggregation. Protein aggregation is one of the main side reactions that competes with protein folding, and it typically results from interactions among partially folded intermediates. It is known that oligomeric proteins can be dissociated by the application of high hydrostatic pressure. Since protein aggregates can be described as nonspecific protein oligomers, it can be predicted that they can be completely or partially dissociated by pressure. The enzyme rhodanese is prone to slow aggregation in 3.9 M urea, and it is widely used as a model for the folding of a protein which readily aggregates. In the present study, it was demonstrated that this aggregation process could be completely reversed under high hydrostatic pressure. Release of the pressure led to renewed protein aggregation. In addition, it was demonstrated that refolding of urea-denatured rhodanese at 2 kbar pressure led to an increased yield of the native enzyme. The final recovery was increased up to approximately 25% in contrast to approximately 5% recovery observed under ambient pressure. The recovery can be further increased in the presence of 4 M glycerol, where 56% of the protein was recovered by treatment with high pressure. These observations suggest that some protein aggregation can be limited without the use of chemical additives, and they show that the pressures needed to maintain solubility are considerably less than those typically required for dissociation of specific oligomers and unfolding of polypeptide chains.
Experiments using microarray technology: limitations and standard operating procedures (2003)

Microarrays are a powerful method for the global analysis of gene or protein content and expression, opening up new horizons in molecular and physiological systems. This review focuses on the critical aspects of acquiring meaningful data for analysis following fluorescence-based target hybridisation to arrays. Although microarray technology is adaptable to the analysis of a range of biomolecules (DNA, RNA, protein, carbohydrates and lipids), the scheme presented here is applicable primarily to customised DNA arrays fabricated using long oligomer or cDNA probes. Rather than provide a comprehensive review of microarray technology and analysis techniques, both of which are large and complex areas, the aim of this paper is to provide a restricted overview, highlighting salient features to provide initial guidance in terms of pitfalls in planning and executing array projects. We outline standard operating procedures, which help streamline the analysis of microarray data resulting from a diversity of array formats and biological systems. We hope that this overview will provide practical initial guidance for those embarking on microarray studies.
Pulsewidth limitation in the relativistic backward wave oscillator (2000)

Spontaneous pulse shortening occurring in a relativistic backward wave oscillator (BWO) at gigawatt power levels is studied in experiment and theory. It is experimentally demonstrated that this phenomenon is accompanied by formation of an explosive-emission plasma at the surface of the corrugated slow-wave structure (SWS). Termination of microwave emission is explained by the increase of the BWO starting current from the absorption of the operating electromagnetic wave by electrons emitted from the plasma, whereas the intensity of the absorption radically increases offing to the presence of positive ions emitted from the plasma. Application of oil-free vacuum and electrochemical polishing of the SWS surface in an X-band BWO allowed generation of 3-GW, 26-ns microwave pulses with an energy of /spl sim/80 J, thereby demonstrating pulse lengthening by a factor of four.
Oncogenes Induce and Activate Endogenous p73 Protein (2001)

The identification of upstream pathways that signal to TP73 is crucial for understanding the biological role of this gene. Since some evidence suggests that TP73 might play a role in tumorigenesis, we asked whether oncogenes can induce and activate endogenous TP73. Here, we show that endogenous p73 alpha and beta proteins are up-regulated in p53-deficient tumor cells in response to overexpressed E2F1, c-Myc, and E1A. E2F1, c-Myc, and E1A-mediated p73 up-regulation leads to activation of the p73 transcription function, as shown by p73-responsive reporter activity and by induction of known endogenous p73 target gene products such as p21 and HDM2. Importantly, E2F1-, c-Myc-, and E1A-mediated activation of endogenous p73 induces apoptosis in SaOs-2 cells. Conversely, inactivation of p73 by a dominant negative p73 inhibitor (p73DD), but not by a mutant p73DD, inhibits oncogene-induced apoptosis. These data show that oncogenes can signal to TP73 in vivo. Moreover, in the absence of p53, oncogenes may enlist p73 to induce apoptosis in tumor cells.
Active contour models for infrared cloudy shapes segmentation (2002)

By nature, the clouds are deformable objects with fuzzy, blurred and indefinite contours. The detection methods usually used (convolution mask for edge detection, linear filtering...) are ineffective for this kind of pattern. Nevertheless, the description of clouds, as closed geometrical patterns, is of great practical interest : it allows one to describe the moving cloudy shape with a lot of geometrical parameters (perimeter, center of gravity, area, energy, orientation of the pattern...) that are not valid for an unclosed shape. Tracking methods for deformable shapes are one of the main lines of research in image processing. This kind of problem is well illustrated by cloudy shapes. The use of an active contour model, called "snake", introduces the concept of deformable closed edges. This article will give an illustration of this new technique for cloudy edge detection and proposes a normalization of energy functions governing the snake evolution. This normalization will allow the final energy level of the snake to be compared for different patterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Effect of oral calcium on blood pressure response in salt-loaded borderline hypertensive patients. (1989)

To clarify the mechanism of the antihypertensive effect of oral calcium loading, we studied the effect of low versus high calcium intake on salt-induced blood pressure elevations in patients with borderline hypertension. After a 7-day period of dietary salt restriction (50 meq/day), 27 patients were placed on a high salt (300 meq/day), low calcium (250 mg/day) diet for 7 days; 14 of these patients were given 2,160 mg/day of supplementary calcium (Ca group), and 13 patients were given placebo (non-Ca group). With a high salt intake, the percent increase in mean blood pressure was smaller in the Ca group than in the non-Ca group (+2.85 +/- 1.22% vs. +8.63 +/- 1.66%, respectively, p less than 0.01). The Ca group showed a smaller weight gain (p less than 0.05) and a greater urinary excretion of sodium (p less than 0.005) than the non-Ca group. In the Ca group, but not in the non-Ca group, high salt intake resulted in an increase in intraerythrocyte magnesium content (p less than 0.01), which was correlated inversely with the salt-induced changes in mean blood pressure (r = -0.54, p less than 0.05). While the increase in cellular magnesium was greater in the Ca group, the changes in red blood cell sodium and sodium/potassium ratio were not different between the two groups. The results suggest that oral calcium supplementation may prevent a rise in blood pressure in patients on a high salt, low calcium diet by attenuating the sodium retention.(ABSTRACT TRUNCATED AT 250 WORDS)