gebhart/patrepeval huggingface dataset:
Abductin. Locus and spectral characteristics of a brown, fluorescent chromophore (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbductin. Locus and spectral characteristics of a brown, fluorescent chromophoreDonald P. ThornhillCite this: Biochemistry 1971, 10, 13, 2644–2649Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/bi00789a035https://doi.org/10.1021/bi00789a035research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Substituents on Electronic Spectral Shifts and Phase Stability of Liquid Crystalline Biphenylcyclohexane Molecules—A Theoretical Approach (2012)

The structures of liquid crystalline disubstituted biphenylcyclohexanes (BCHs) of the general formula R-C6H10-C6H4-C6H4-X with R: C3H7; X: H (BCH30), and R: C5H11; X: CN (BCH5CN) have been optimized using the density function B3LYP with 6–31+G (d) basis set using crystallographic geometry as input. Using the optimized geometry, electronic structures of the molecules have been evaluated using the density functional theory (DFT) calculations. Mulliken atomic charges for each molecule have been compared with Loewdin atomic charges to understand the molecular charge distribution and phase stability. The electronic absorption spectra and circular dichroism (CD) spectra of BCH molecules have been simulated by employing the DFT method. The excited states have been calculated via configuration interaction single level (CIS) with semiempirical Hamiltonian ZINDO. Two types of calculations have been performed for model systems containing single and double molecules of BCHs. Further, the spectra have been reported for all single molecules, and the ultraviolet (UV) stability of the molecules has been discussed. The stacked and in-plane dimer complexes have also been reported to enable the comparison between single and double molecules.
Extended Jones matrix method II (1993)

We derive an extended Jones matrix method to treat the transmission of light through birefringent networks, where the incident angle of light and the optical axis of the birefringent media are arbitrary. As an example, we employ the method to analyze the leakage problem of a twisted nematic liquid-crystal display and to suggest its possible solutions. A generalization of the method covers all dielectric media, including uniaxial and biaxial crystals and also gyrotropic materials that exhibit optical rotation and Faraday rotation.
Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains (1992)

Bistropolone derivatives (4-12) containing differing lengths of linkage between the two tropolone rings were prepared and examined for their antitumor activity in in vitro (KB cell) and in vivo (leukemia P388 in mice) systems. Parent compound 3, related compounds previously prepared, and the new compounds 4-12 were evaluated for inhibitory activity against ribonucleotide reductase by indirect means to measure their effects on the dNTP pool imbalance. Present structure-activity relationship results would suggest that potently active bistropolones in vivo inhibit intracellular ribonucleotide reductase through chelating with the two irons at the two active sites of the enzyme.
THE USE OF BUFFERED L-ARGININE IN THE TREATMENT OF CYSTIC FIBROSIS (1971)

Buffered L-arginine was administered to 22 patients with cystic fibrosis in an attempt to improve pulmonary function and fat absorption. Arginine was selected because of its low toxicity, ability to break hydrogen bonds, bind metal ions, and act as a detergent. When arginine was administered by inhalation as an ultrasonicated mist to eight patients with chronic lung diseases, improvements occurred in vital capacity, thoracic gas volume, specific conductance, and arterial Po2. Oral administration of arginine to patients with predominantly gastrointestinal symptomatology resulted in rapid relief of abdominal pain, weight gain in all the patients treated in this fashion, and improved fat absorption in 11 out of 14 patients. There were no important side effects attributable to the inhalation or oral administration of buffered arginine.
Glutamine Binding Opens the Ammonia Channel and Activates Glucosamine-6P Synthase (2005)

Glucosamine-6P synthase catalyzes the synthesis of glucosamine-6P from fructose-6P and glutamine and uses a channel to transfer ammonia from its glutaminase to its synthase active site. X-ray structures of glucosamine-6P synthase have been determined at 2.05 Angstroms resolution in the presence of fructose-6P and at 2.35 Angstroms resolution in the presence of fructose-6P and 6-diazo-5-oxo-L-norleucine, a glutamine affinity analog that covalently modifies the N-terminal catalytic cysteine, therefore mimicking the gamma-glutamyl-thioester intermediate formed during hydrolysis of glutamine. The fixation of the glutamine analog activates the enzyme through several major structural changes: 1) the closure of a loop to shield the glutaminase site accompanied by significant domain hinging, 2) the activation of catalytic residues involved in glutamine hydrolysis, i.e. the alpha-amino group of Cys-1 and Asn-98 that is positioned to form the oxyanion hole, and 3) a 75 degrees rotation of the Trp-74 indole group that opens the ammonia channel.
Evaluation of Four Affibody-Based Near-Infrared Fluorescent Probes for Optical Imaging of Epidermal Growth Factor Receptor Positive Tumors (2012)

This work demonstrates that Affibody proteins can be modified with different NIR fluorescent dyes and used for imaging of EGFR expressing tumors. Different NIR fluorescent dyes have variable impact on the in vitro binding and in vivo performance of the resulting Affibody based probes. Therefore, selection of an appropriate NIRF label is important for optical probe development. The probes developed are promising for further tumor imaging applications and clinical translation. Particularly, Alex680-ZEGFR:1907 and Cy5.5-ZEGFR:1907 are excellent candidates as EGFR-targeted probes for optical imaging.
Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study (2008)

These results suggest that B12 replacement is unlikely to benefit cognitive or psychiatric symptoms in the vast majority of elderly dementia patients with low serum B12 levels.
Opto-ferroelectric memories using vinylidene fluoride copolymers (2003)

The authors demonstrate that ferroelectric polymers can be applied to erasable optical memories. The media developed consists of a 1- mu m-thick layer of a dye-doped vinylidene fluoride/trifluoroethylene copolymer spin-coated onto an indium-tin-oxide (ITO)-coated glass plate. Information is written in terms of sequences of positive and negative polarizations, which are generated by irradiating a focused laser beam 5 mu m in diameter with the aid of a sign-controlled electric field. The data are read out pyroelectrically by scanning the laser beam.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Thermal Properties and Fire Performance of Woven Glass Fibre Reinforced Nylon 6 Nano-Composites with Carbon Nanotubes (2008)

This paper presents the effects of incorporating carbon nanotubes (CNT) into nylon 6 on thermal properties and fire performance of woven glass reinforced CNT/nylon 6 nanocomposite laminates. Incorporation of CNT in nylon 6 improved the thermal stabilities, thermal conductivity and fire performance of laminates without compromising their mechanical properties. The thermal conductivity of laminates with 2 wt% CNT increased up to 42% compared to that without CNT. The ignition time and peak HRR time was delayed approx. 31% and 118%, respectively, in laminates with 4 wt% CNT in nylon 6 over that without CNT.
Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis (2006)

The first examples of catalytic asymmetric ring-closing metathesis (ARCM) reactions of enol ethers are reported. To identify the most effective catalysts, various chiral Mo- and Ru-based catalysts were screened. Although chiral Ru catalysts (those that do not bear a phosphine ligand) promote ARCM in some cases, such transformations proceed in <10% ee. In contrast, Mo-based alkylidenes give rise to efficient ARCM and deliver the desired products in the optically enriched form. Thus, Mo-catalyzed enantioselective transformations allow access to various five- and six-membered cyclic enol ethers in up to 94% ee from readily available achiral starting materials. The first examples of catalytic ARCM that lead to the formation of all-carbon quaternary stereogenic centers are also disclosed. Mechanistic models that offer a plausible rationale for the identity of major enantiomers as well as the observed levels of enantioselectivity are provided. Representative examples demonstrate that the enol ether moiety and the unreacted alkene of the ARCM products can be discriminated with excellent site selectivity (>98%).
Mesenchymal stem cells as living anti-inflammatory therapy for COVID-19 related acute respiratory distress syndrome (2020)

Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), is growing at an exponential rate worldwide. Manifestations of this disease are heterogeneous; however, advanced cases often exhibit various acute respiratory distress syndrome-like symptoms, systemic inflammatory reactions, coagulopathy, and organ involvements. A common theme in advanced COVID-19 is unrestrained immune activation, classically referred to as a "cytokine storm", as well as deficiencies in immune regulatory mechanisms such as T regulatory cells. While mesenchymal stem cells (MSCs) themselves are objects of cytokine regulation, they can secrete cytokines to modulate immune cells by inducing anti-inflammatory regulatory Treg cells, macrophages and neutrophils; and by reducing the activation of T and B cells, dendritic and nature killer cells. Consequently, they have therapeutic potential for treating severe cases of COVID-19. Here we discuss the unique ability of MSCs, to act as a "living anti-inflammatory", which can "rebalance" the cytokine/immune responses to restore equilibrium. We also discuss current MSC trials and present different concepts for optimization of MSC therapy in patients with COVID-19 acute respiratory distress syndrome.
Cloretazine (VNP40101M), a Novel Sulfonylhydrazine Alkylating Agent, in Patients Age 60 Years or Older With Previously Untreated Acute Myeloid Leukemia (2006)

Cloretazine has significant activity and modest extramedullary toxicity in elderly patients with AML or high-risk MDS. Response rates remain consistent despite increasing age and comorbidity.
Two stage CCI/ISI reduction with space-time processing in TDMA cellular networks (2002)

We propose a two-stage, separate cochannel interference (CCI) and intersymbol interference (ISI) reduction technique using space-time processing. CCI and ISI are two major interference sources in wireless communication, and they are the limiting factors in the performance and capacity of a cellular network. However because of the different characteristics between CCI and ISI, algorithms designed to simultaneously reduce both interferences tend to combat ISI more and ignore CCI, which causes performance degradation of the equalizer. Further more, MLSE-type algorithms can effectively reduce ISI while MMSE-type algorithms are more robust to CCI. These considerations motivate us to derive two-stage interference reduction: the first stage uses a space-time MMSE equalizer to reduce CCI while preserving the ISI structure of the desired signal; the second stage uses a space-time Viterbi equalizer to reduce ISI. Space-time processing assures spatial and temporal diversities are fully captured and the difference of spatial and temporal properties between signals and interferences are fully explored. Simulation results show the proposed approach leads to good performance in a GSM scenario even at low carrier-to-interference ratio.
Using Games in Software Engineering Education to Teach Risk Management (2007)

An innovative board game was developed at Carnegie Mellon University's Master in Software Engineering Program to teach risk management concepts. Piloted in two separate courses dealing with software project risk management, the goal of the game was to enhance practical learning and decision making through simulating a software development project. This activity was then compared to others used in the class, specifically lectures and case discussions, to assess its effectiveness in meeting learning objectives. The results clearly demonstrate the advantages of using a game method in teaching software engineering concepts. Findings will discuss how the game compares to other teaching activities in the classroom in terms of conveying relevant information, help in concept understanding and learning enjoyment.
Live-chat agent assignments to heterogeneous e-customers under imperfect classification (2011)

Many e-commerce firms provide live-chat capability on their Web sites to promote product sales and to offer customer support. With increasing traffic on e-commerce Web sites, providing such live-chat services requires a good allocation of service resources to serve the customers. When resources are limited, firms may consider employing priority-processing and reserving resources for high-value customers. In this article, we model a reserve-based priority-processing policy for e-commerce systems that have imperfect customer classification. Two policy decisions considered in the model are: (1) the number of agents exclusively reserved for high-value customers, and (2) the configuration of the classification system. We derive explicit expressions for average waiting times of high-value and low-value customer classes and define a total waiting cost function. Through numerical analysis, we study the impact of these two policy decisions on average waiting times and total waiting costs. Our analysis finds that reserving agents for high-value customers may have negative consequences for such customers under imperfect classification. Further, we study the interaction between the two policy decisions and discuss how one decision should be modified with respect to a change in the other one in order to keep the waiting costs minimized.
Work‐related stress in health service employees (1995)

Abstract Levels of work‐related stress were examined in 1,176 employees from the major occupational groups of one large health authority in the UK as a precursor to devising stress management strategies. The six occupational groups (administrative and clerical staff, ancillary personnel, professions allied to medicine, doctors and ward‐and community‐based nurses) were compared and the results were used as a basis for suggesting opportunities for management to initiate a range of stress management interventions. The framework suggested by Cox was used, which suggests that the target for intervention can be either the individual or organization and that there are three levels: prevention; tackling stressors at work; and helping individuals cope with problems at work. While stress was found to be a significant problem across all occupational groups in the study and their experience of stress has many similarities, the stress management solutions need to be tailored to the needs of each occupational group.
Joint algorithm/code-level optimization of H.264 video decoder for mobile multimedia applications (2008)

In this paper, we propose a joint algorithm/code-level optimization scheme to make it feasible to perform real-time H.264/AVC video decoding software on ARM-based platform for mobile multimedia applications. In the algorithm-level optimization, we propose various techniques like fast interpolation scheme, zero-skipping technique for texture decoding, fast boundary strength decision for in-loop filtering, and pattern matching algorithm for CAVLD. In the code-level optimization, we propose the design techniques on minimizing memory access and branch times. The experimental result shows that we have reduced the complexity of H.264 video decoder up to 93% as compared to the reference software JM9.7. The optimized H.264 video decoder can achieve the QCIF@30Hz video decoding on an ARM9 processor when operating at 120MHz clock.
Food and Drug Administration (<scp>FDA</scp>) drug approval end points for chronic cutaneous ulcer studies (2012)

The rising costs of caring for chronic cutaneous ulcers (CCUs) and recent appreciation of the mortality of CCUs have led to consideration of the reasons for the failure to have new drug therapies. No new chemical entities to heal CCUs have been approved by the Food and Drug Administration (FDA) in over a decade, in part due to an inability to reach the FDA accepted end point of "complete wound closure." The frequent failure to reach the complete closure end point brings forward the question of the relevance of other healing end points such as improved quality of life, or partial healing. Because CCUs carry a prognosis and mortality rate worse than many cancers, it is reasonable to compare the FDA trial end points for cancer drug approval with those for CCUs. And the difference is quite striking. While there is only one end point for CCUs, there are five surrogate and three direct end points for cancers. In contrast to cancer, surrogate end points and partial healing are not acceptable for therapies aimed at CCUs. For example, making tumors smaller is an acceptable end point, but making CCUs smaller is not and improvement in the signs and symptoms of cancer is an acceptable end point for cancers but not CCUs. As CCUs carry a prognosis and mortality rate worse than many cancers, we believe a reconsideration of end points for CCUs is highly warranted.
An OFDM System Concept for Joint Radar and Communications Operations (2009)

In this paper the possibility of designing an OFDM system for simultaneous radar and communications operations is discussed. A novel approach to OFDM radar processing is introduced that overcomes the typical drawbacks of correlation based processing. A suitable OFDM system parameterization for operation at 24 GHz is derived that fulfills the requirements for both applications. The operability of the proposed system concept is verified with MatLab simulations.
Electron Mobility, Conductivity, and Superconductivity near the Metal-Insulator Transition (1984)

The disorder parameter ${k}_{\mathrm{F}}l$ for amorphous $\mathrm{In}{\mathrm{O}}_{x}$ is measured by a novel application of the surface electric field effect and is varied by thermal annealing. The normal-state conductivity and superconducting ${T}_{c}$ both vary as ${({k}_{\mathrm{F}}l)}^{\ensuremath{-}2}$ and critical disorder occurs at ${k}_{\mathrm{F}}l\ensuremath{\approx}{3}^{\frac{1}{2}}$, as a result of Anderson localization in this low---carrier-density material.
Digital processing of signals: Theory and practice (1984)

From the Publisher:
A concise treatment of the principles of digital processing of signals, with emphasis on engineering aspects. Addresses problems of design and implementation, including project evaluation and applications to telecommunications. This new edition has been fully revised and updated, covering computational complexity analysis for FIR, IIR, Multirate, and adaptive filters. Contains extended bibliographies, references, and exercises with answers.
Fine‐Tuning Dual Emission and Aggregation‐Induced Emission Switching in NPI–BODIPY Dyads (2014)

Three new NPI-BODIPY dyads 1-3 (NPI = 1,8-naphthalimide, BODIPY = boron-dipyrromethene) were synthesized, characterized, and studied. The NPI and BODIPY moieties in these dyads are electronically separated by oxoaryl bridges, and the compounds only differ structurally with respect to methyl substituents on the BODIPY fluorophore. The NPI and BODIPY moieties retain their optical features in molecular dyads 1-3. Dyads 1-3 show dual emission in solution originating from the two separate fluorescent units. The variations of the dual emission in these compounds are controlled by the structural flexibilities of the systems. Dyads 1-3, depending on their molecular flexibilities, show considerably different spectral shapes and dissimilar intensity ratios of the two emission bands. The dyads also show significant aggregation-induced emission switching (AIES) on formation of nano-aggregates in THF/H2O with changes in emission color from green to red. Whereas the flexible and aggregation-prone compound 1 shows AIES, rigid systems with less favorable intermolecular interactions (i.e., 2 and 3) show aggregation-induced quenching of emission. Correlations of the emission intensity and structural flexibility were found to be reversed in solution and aggregated states. Photophysical and structural investigations suggested that intermolecular interactions (e.g., π-π stacking) play a major role in controlling the emission of these compounds in the aggregated state.
Shelf life stability of lactobacilli encapsulated in raspberry powder: Insights into non-dairy probiotics (2014)

A combination of processing conditions: inlet temperature (°C), maltodextrin to juice solids ratio and inlet feed rate (ml/min) during spray drying had a significant role on the survival of lactobacilli during shelf life. Refrigerated storage provided a higher shelf-life stability with regards to CFU/g (as high as 84% on day 0 and 98% retention by the end of 30 d) compared to room temperature storage. Probiotic properties during shelf life are affected by the processing conditions and encapsulated food matrix. Thus, understanding these aspects in vitro during shelf life gives us a brief insight into the future of non-dairy probiotics.