gebhart/patrepeval huggingface dataset:
Modification and evaluation of a high-volume air sampler for pesticides and semivolatile industrial organic chemicals (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification and evaluation of a high-volume air sampler for pesticides and semivolatile industrial organic chemicalsRobert G. Lewis and Merrill D. JacksonCite this: Anal. Chem. 1982, 54, 3, 592–594Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ac00240a058https://doi.org/10.1021/ac00240a058research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tutorial on the event-based B method (2006)

B is a method for specifying, designing and coding software systems. It is based on Zermelo-Fraenkel set theory with the axiom of choice, the concept of generalized substitution and on structuring mechanisms (machine,refinement, implementation). The concept of refinement is the key notion for developing B models of (software) systems in an incremental way. B models are accompanied by mathematical proofs that justify them. Proofs of B models convince the user (designer or specifier) that the (software) system is effectively correct. We provide a survey of the underlying logic of the B method and the semantic concepts related to the B method; we detail the B development process partially supported by the mechanical engine of the prover.
Three‐dimensional electron microscopy of entire cells (1990)

The digital processing of serial electron-microscope sections containing laser-induced topographical references allows a three-dimensional (3-D) reconstruction of entire cells at a depth resolution of 40-60 nm by the use of novel image analysis methods. The images are directly processed by a video-camera placed under the electron microscope in TEM mode or by the electron counting device in STEM mode. The deformations associated with the cutting of embedded cells are back-calculated by new computer algorithms developed for image analysis and treatment. They correct the artefacts caused by serial sectioning and automatically reconstruct the third dimension of the cells. Used in such a way, our data provide definitive information on the 3-D architecture of cells. This computer-assisted 3-D analysis represents a new tool for the documentation and analysis of cell ultrastructure and for morphometric studies. Furthermore, it is now possible for the observer to view the contents of the reconstructed tissue volume in a variety of different ways using computer-aided display techniques.
Decarboxylation and fragmentation of 5,6-dihydro-4H-1,2-oxazine-3-carboxylic acids (1979)

The title compounds, which are derived from the cycloaddition of α-nitroso-acrylic esters or of α-nitrosoacrolein to olefins, are thermally decarboxylated to give γ-hydroxynitriles in a stereoselective process.
Twelfth meeting of the Association for Symbolic Logic (1950)

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A Novel Gene Gun-Mediated IL-12 Gene Therapy for Breast Cancer (1999)

Abstract : The overall goal of our research is to develop an immunological approach for breast cancer gene therapy. The results of the first year study, described in our previous Annual Report, show that gene gun-mediated IL-12 gene therapy is effective against breast tumors in mouse models. During the second year of this study we demonstrated that 4T1 tumor is weakly immunogenic, and it can induce a low level immune response. However, the anti-metastatic effect of IL-12 gene therapy against 4T1 tumor is not mediated by T cells, but rather involves NK cells. From several different immunomidulatory genes tested in combination with IL-12 gene therapy, IL-18 and ICE were found to be more effective in treatment of established TS/A breast tumor than IL-12 alone. In a separate, but strategically relevant approach for cancer gene immunotherapy, a striking antitumor effect was demonstrated in mice vaccinated with a gene encoding the tumor-associated antigen gp100 in combination with a GM-CSF gene. The results of this study strongly suggest that gene gun-mediated in vivo IL-12 gene therapy approach in combination with other immunological approaches may be developed as an effective and safe alternative to systemic IL- 12 protein for treatment of breast cancer.
Common mode current attenuation techniques for use with PWM drives (2001)

The most common modulation strategy adopted for motor control in adjustable speed drives (ASDs) is pulse width modulation (PWM). In general, the output is modulated at a carrier frequency ranging from 1.0 kHz to 20.0 kHz. Experiences with PWM drives have shown that there exist two important concerns: (1) common mode current; and (2) over-voltage at the motor when the distance between motor and the inverter is larger than the critical distance. The high carrier frequency along with fast rise and fall time of the insulated gate bipolar transistors (IGBTs) employed results in nontrivial common-mode or ground currents. The high dv/dt causes shaft voltage, which leads to bearing currents. This phenomenon has been identified as one of the reasons for premature bearing failure in PWM driven motors. A new scheme to attenuate the common mode noise and hence reduce shaft voltage is proposed. Experimental results showing the effectiveness of the proposed solution is also presented.
On Clock Frequency Effects in Side Channel Attacks of Symmetric Block Ciphers (2012)

Differential power analysis (DPA) becomes cumbersome when the analyzed traces are misaligned. The misalignment can be caused by deliberately inserting dummy wait states, random CPU stalls, or a random clock. In this paper we discuss clock frequency effects in random clock equipped cryptosystems and show that the power traces captured accordingly feature not only shifts in time domain, but also changes in the amplitude domain. These changes are more significant when increasing the base clock frequency. Therefore, trace preprocessing before performing an effective power analysis attack is necessary. We thus discuss first some existing alignment methods in time domain and then propose a method to normalize the horizontally aligned traces in the amplitude domain. As a demonstrator for these effects, a random clock armed AES-128 cryptosystem will be attacked at 2, 7, and 12 MHz base clock frequency, respectively. The experiments clearly unveil that at higher clock frequencies just a horizontal alignment is not sufficient. It is therefore necessary to preprocess the horizontally aligned traces in the amplitude domain too, which can neutralize the observed clock frequency effects and may greatly enhance a subsequent DPA attack.
Critical Limb Ischemia: Cell and Molecular Therapies for Limb Salvage (2012)

There is a growing interest in developing new limb salvage therapies for patients with severe peripheral artery disease who have no alternative to amputation. Cell and gene therapy studies are showing promise in controlling pain and minor ulceration in patients with significant critical limb ischemia. Among cardiovascular cell and molecular therapy programs, The Methodist Hospital is one of the leading centers in both gene and cell therapy for critical limb ischemia. Randomized controlled trials continue to be performed, and these experimental therapies will move from research to pharmacy within the decade. In conjunction with aggressive medical and surgical management, these emergent therapies may help patients with critical limb ischemia avoid a major amputation and are one of the foundations of any advanced limb salvage program.
Interaction between the<i>GROWTH-REGULATING FACTOR</i>and<i>KNOTTED1-LIKE HOMEOBOX</i>Families of Transcription Factors   (2014)

KNOTTED1-LIKE HOMEOBOX (KNOX) genes are important regulators of meristem function, and a complex network of transcription factors ensures tight control of their expression. Here, we show that members of the GROWTH-REGULATING FACTOR (GRF) family act as players in this network. A yeast (Saccharomyces cerevisiae) one-hybrid screen with the upstream sequence of the KNOX gene Oskn2 from rice (Oryza sativa) resulted in isolation of OsGRF3 and OsGRF10. Specific binding to a region in the untranslated leader sequence of Oskn2 was confirmed by yeast and in vitro binding assays. ProOskn2:β-glucuronidase reporter expression was down-regulated by OsGRF3 and OsGRF10 in vivo, suggesting that these proteins function as transcriptional repressors. Likewise, we found that the GRF protein BGRF1 from barley (Hordeum vulgare) could act as a repressor on an intron sequence in the KNOX gene Hooded/Barley Knotted3 (Bkn3) and that AtGRF4, AtGRF5, and AtGRF6 from Arabidopsis (Arabidopsis thaliana) could repress KNOTTED-LIKE FROM ARABIDOPSIS THALIANA2 (KNAT2) promoter activity. OsGRF overexpression phenotypes in rice were consistent with aberrant meristematic activity, showing reduced formation of tillers and internodes and extensive adventitious root/shoot formation on nodes. These effects were associated with down-regulation of endogenous Oskn2 expression by OsGRF3. Conversely, RNA interference silencing of OsGRF3, OsGRF4, and OsGRF5 resulted in dwarfism, delayed growth and inflorescence formation, and up-regulation of Oskn2. These data demonstrate conserved interactions between the GRF and KNOX families of transcription factors in both monocot and dicot plants.
Pulsed laser ablation synthesis and characterization of layered Pt/SrBi2Ta2O9/Pt ferroelectric capacitors with practically no polarization fatigue (1995)

Pulsed laser ablation deposition was used to synthesize polycrystalline SrBi2Ta2O9 layered ferroelectric thin films on platinized silicon substrates. Top electrodes were produced by dc magnetron sputter deposition to fabricate capacitors for electrical tests. The polarization electric field hysteresis loops showed saturation in the 2–4 V range with a coercive field of 25 kV/cm. The capacitors showed practically no polarization fatigue up to 1011 switching cycles. The resistivity of the SrBi2Ta2O9 for a coercive field of 100 kV/cm was approximately 2×1011 Ω cm. Retention and imprint characteristics of these capacitors showed no degradation as a function of cumulative waiting times.
Service-oriented design and development methodology (2006)

SOA is rapidly emerging as the premier integration and architectural approach in contemporary complex, heterogeneous computing environments.SOA is not simply about deploying software: it also requires that organizations evaluate their business models, come up with service-oriented analysis and design techniques, deployment and support plans, and carefully evaluate partner/customer/supplier relationships.Since SOA is based on open standards and is frequently realized using Web services, developing meaningful Web service and business process specifications is an important requirement for SOA applications that leverage Web services.Designers and developers cannot be expected to oversee a complex service-oriented development project without relying on a sound design and development methodology.This paper provides an overview of the methods and techniques used in service-oriented design and development.Aim of this paper is to examine a service development methodology from the point of view of both service producers and requesters and review the range of elements in this methodology that are available to them.
Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins. (1993)

The cyclic AMP (cAMP) response element (CRE) of the rat glucagon gene (Glu-CRE, 5'-TGACGTCA-3') mediates transcriptional responses to 8-bromo-cAMP and protein kinase A (PKA) in a glucagon-producing hamster islet cell line (InR1G9). By several different DNA-protein binding assays, we show that the transcription factor CREB binds to the CRE octamer and that additional nuclear proteins bind to sequences adjacent to the CRE. Mutation of the Glu-CRE octamer attenuates both the binding of CREB and cAMP-dependent PKA-stimulated transcriptional activity in transient transfection experiments but does not affect the binding of adjacent CREB-associated proteins. Progressive deletions and clustered point mutations of the sequences flanking the Glu-CRE identify sequences (5'-TCATT-3') located both 5' and 3' to the core CRE octamer that bind several proteins. Two proteins with molecular masses of 80 and 100 kDa bind to each of the 5' and 3' TCATT sites. Formation of additional protein-DNA complexes containing 45- and 20-kDa proteins depends upon the integrity of both TCATT sequences. Deletion or point mutation of the TCATT motif located on the 3' side of the CRE octamer results in enhanced transcriptional responses to PKA, suggesting that the CREB-associated proteins decrease the ability of CREB to mediate PKA-stimulated transcription. Results from these studies demonstrate that nucleotides flanking the core CRE octamer can influence the activity of the CRE by serving as binding sites for proteins that modulate the function of CREB and suggest a mechanism to explain why some consensus palindromic CREs are less responsive to cAMP stimulation than others.
Analyzing the Timing Characteristics of Task Activations (2006)

We propose a model and method to determine the temporal distribution of task activations occurring within an event driven real time system. As real time systems even in safety critical applications are becoming increasingly complex, it becomes increasingly important to get a better understanding of the activity within these systems. The event stream model is a powerful yet efficient way to describe the temporal occurrence of events within a system. Real time analysis can be elegantly performed using given event streams, however it has so far not been investigated how the event streams themselves can be acquired. By calculating the temporal distribution of task activations within a system, a more accurate description of the timing behavior of a system is possible which in the end can lead to a save and cost efficient estimate on the hardware required for the system.
Synthesis, structure and photophysical properties of near-infrared 3,5-diarylbenzoBODIPY fluorophores (2016)

An efficient synthetic method for 3,5-diarylbenzoBODIPYs was reported, which showed tunable absorption/emission <italic>via</italic> the variation of the 3,5-aryl substituents.
조직과 개인특성이 직무적합성을 통해 경력몰입과 경력만족에 미치는 영향 (2012)

기존 연구는 경력에 있어 임금, 승진, 직급과 같은 객관적인 가치뿐만 아니라 경력에서 느끼는 개인의 심리적인 주관적 가치에도 관심을 기울여야 한다는 것을 시사한다. 이러한 선행 연구결과를 바탕으로 이 연구는 경력몰입과 경력만족에 있어 조직특성과 개인특성이 어떠한 영향을 미치는가와 그러한 관계에서 직무적합성의 매개효과를 검증하는데 목적이 있다. 이를 위해 서울에 소재한 전자산업 분야의 대기업인 A기업에 소속된 근무연한 3년 이상, 사무직 232명을 대상으로 설문조사를 실시하였다. 설문지에는 조직특성 변인으로 상사의 지원과 성장기회가, 개인특성 변인으로는 자아존중감과 고용가능성이 사용되었고, 직무적합성, 경력몰입과 경력만족 변인이 포함되었다. 연구 결과 첫째, 조직특성은 경력몰입과 경력만족에 정(+)의 유의미한 영향을 미치고, 개인특성은 경력몰입과 경력만족에 직접적인 영향을 주지 못하였다. 둘째, 직무적합성에는 개인특성만이 정(+)의 유의미한 관계를 보여주는 것으로 나타났다. 셋째, 직무적합성은 경력몰입에 정(+)의 유의미한 영향을 미치는 반면, 경력만족에는 아무런 영향을 미치지 못하였다. 넷째, 직무적합성은 개인특성과 경력몰입간의 관계를 매개를 하고 있다. 이론적인 면에서 이 연구는 조직특성이 경력몰입과 경력만족에 영향을 미치는 인과모형뿐만 아니라 개인특성이 직무적합성을 매개로 경력몰입에 영향을 주는 인과모형을 제시하였다. 실무적으로는 조직차원의 경력에 대한 제도와 지원을 일반 사무직에게까지 확대해야 할 필요성을 확인하였다. 이러한 연구 결과를 바탕으로 시사점과 연구의 한계 그리고 향후 연구방향이 논의되었다.
Tendon Healing Within the Flexor Digital Sheath in the Dog (1962)

1. The processes of tendon healing within the canine flexor digital sheath following aseptic division and as nearly atraumatic repair as possible are described. 2. Under these conditions only the sheath tissues provide the active healing elements in the healing of a flexor digital tendon within its sheath. The tendon is united by a scar produced by fibroblasts derived from the sheath. These fibroblasts lay down collagen which by 128 days is indistinguishable from that of the tendon proper. 3. Microscopically, wounds before twenty-eight days appear too immature for active mobilization. By thirty-five days they look as though they would function satisfactorily. 4. Nutrition of the fibroblasts derived from the sheath and the nutrition of the scar they produce may be provided by the loose filmy adhesions which persist between the sheath and tendon scar. There is no evidence that these adhesions interfere with the function of the healed tendon.
Oxidative decarboxylation of glucuronosides and the synthesis of xylitol (2004)

The purpose of this research was to develop a novel chemical synthesis of xylitol, which could potentially be implemented on an industrial scale. Principally, the oxidative decarboxylation of glucuronosides was pursued as a novel route to yield xylitol, although experiments with free glucuronic acid and aldonic acids were also executed. Several chemical decarboxylation techniques were studied including anodic decarboxylation, variants of the Ruff degradation, hypochlorous acid decarboxylation, and others. Anodic decarboxylation was found to be the only successful method for the desired degradation of glucuronosides. The Hofer-Moest (non-Kolbe) decarboxylation, and mechanism thereof, is submitted as the reaction of interest. As such, glucuronosides undergo a one-electron oxidation to form an acyloxy radical, which decomposes to form carbon dioxide and a C-5 radical. The radical is subsequently oxidized to a cation. The cation undergoes nucleophilic attack from the solvent (water), which product, upon spontaneous hydrolysis, yields xylo-pentodialdose. Although not effective in the decarboxylation of glucuronosides, the Ruff degradation (notably the copper variant) is considered in detail in this study. The reaction is critically reviewed and previous attempts at mechanistic description are challenged. The Hofer-Moest decarboxylation mechanism is presented as the mechanism of the Ruff degradation, and supporting evidence for such is offered. Cu(III) is submitted as the active species of the copper variant of the Ruff degradation.
From digital libraries to electronic catalogues for engineering and manufacturing (2003)

Over the last decade, a formal data model of libraries of parts for manufacturing and engineering has been developed. This model, known as PLIB, officially ISO 13584, is suitable not only for the exchange of files containing parts, independent of any application that is using these files, but also as a basis for implementing and sharing databases of parts library data. More recently, a strong requirement emerged for exchanging also electronic catalogues containing parts library data. This paper proposes an approach for integrating the data model-oriented view and the document oriented view on the same information, namely parts definition and representation information. This integration embeds three levels. At the modelling level, rules are defined for deriving an XML document type definition from an information model in the EXPRESS language. At the implementation level, an approach is defined for integrating authoring tools, based on XML, and semantic checkers, based on EXPRESS. At the data file level, the proposed integration results in a concept of semantic document that is both human readable and semantically computer-sensible. Application of this approach for capturing parts library data and for generating active documents is presented.
Attenuation and recovery of nerve growth factor receptor mRNA in dorsal root ganglion neurons following axotomy (1996)

The actions of nerve growth factor (NGF) are mediated by two receptor proteins, trk and p75. Recent evidence indicates that NGF upregulates the expression of both trk and p75 in responsive neurons including rat dorsal root ganglion (DRG) neurons. Axotomy by disconnecting the neuron from its source of target-derived NGF is predicted to lead to the downregulation of trk and p75 expression. However, previous studies of the effects of axotomy on trk and p75 mRNA expression in rat DRG have yielded discrepant results. We report that following sciatic nerve crush, trk and p75 mRNA levels in L4-L6 DRG decrease to approximately 50% of control levels at 4-14 days, return to control levels by 30 days, and are increased by approximately 30% at 60 days. Similar changes are observed following nerve transection although mRNA levels are slower in returning to normal and do not exceed control levels at later timepoints. Thus, trk and p75 expression decline early following target disconnection and later recover irrespective of target reinnervation. These observations indicate that target derived NGF is required for the maintenance of NGF receptor expression in adult rat DRG neurons and that non-target derived factors can appropriate this function following peripheral nerve injury.
Synthetic Receptors Make It Possible To Turn Genes On and Off at Will (1993)

RETURN TO ISSUEPREVNewsNEXTSynthetic Receptors Make It Possible To Turn Genes On and Off at WillNew form of human gene therapy could come from ability to use small molecules to control gene transcription in cellsSTU BORMAN View Author Information C&EN WashingtonCite this: Chem. Eng. News 1993, 71, 46, 55–57Publication Date (Print):November 15, 1993Publication History Published online11 November 2010Published inissue 15 November 1993https://pubs.acs.org/doi/10.1021/cen-v071n046.p055https://doi.org/10.1021/cen-v071n046.p055newsACS PublicationsCopyright © 1993 AMERICAN CHEMICAL SOCIETYArticle Views15Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Receptors Get e-Alerts