gebhart/patrepeval huggingface dataset:
A Survey of Load Balancing in Cloud Computing: Challenges and Algorithms (2012)

Load Balancing is essential for efficient operations indistributed environments. As Cloud Computing is growingrapidly and clients are demanding more services and betterresults, load balancing for the Cloud has become a veryinteresting and important research area. Many algorithms weresuggested to provide efficient mechanisms and algorithms forassigning the client's requests to available Cloud nodes. Theseapproaches aim to enhance the overall performance of the Cloudand provide the user more satisfying and efficient services. Inthis paper, we investigate the different algorithms proposed toresolve the issue of load balancing and task scheduling in CloudComputing. We discuss and compare these algorithms to providean overview of the latest approaches in the field.
Enhancing the quality of life through wearable technology (2003)

An overview of the key challenges facing the practice of medicine today is presented along with the need for technological solutions that can "prevent" problems. Then, the development of the Wearable Motherboard/spl trade/ (Smart Shirt) as a platform for sensors and monitoring devices that can unobtrusively monitor the health and well being of individuals (directly and/or remotely) is described. This is followed by a discussion of the applications and impact of this technology in the continuum of life-from preventing SIDS to facilitating independent living for senior citizens. Finally, the future advancements in the area of wearable, yet comfortable, systems that can continue the transformation of healthcare - all aimed at enhancing the quality of life for humans - are presented.
Más allá de la imagen; rompiendo con la hegemonía (1999)

espanolNos proponemos dar a conocer nuestra vision de la lectura de imagenes, para comprender asi mejor nuestro tiempo, en el que lo mas frecuente es meternos por los ojos lo que hay que pensar, lo que hay que decir y lo que hay que hacer, suscitando y dirigiendo las acciones hacia un fin, moldeando la personalidad de los individuos EnglishWe intend to give to know our vision of the reading of images, to understand this way better our time, in which the most frequent thing is to enter for the eyes what it is necessary to think, what it is necessary to say and what it is necessary to make, raising and directing the actions toward an end, modeling the personality of the individuals
Image-guided robotic mastoidectomy using human-robot collaboration control (2011)

This work proposes an image-guided robotic Mastoidectomy. A surgical navigation software was developed to guide the robot without damaging the critical area. A forbidden-region virtual fixture is implemented for safety. A human-robot collaboration control mode is used to allow the human intervention during surgery, to compensate tremor by operator, and to protect the relevant organs. A temporal bone replica was used as a phantom for the robotic Mastoidectomy. Through the phantom studies, it was shown that the image-guided robotic approach is effective for safe and precise Mastoidectomy.
<i>In Vivo</i>Evaluation of Limiting Brain Penetration of Probes for α<sub>2C</sub>-Adrenoceptor Using Small-Animal Positron Emission Tomography (2010)

To evaluate in vivo brain penetration of α(2C)-adrenoceptor (α(2C)-AR) antagonists as a therapeutic agent, we synthesized two new (11)C-labeled selective α(2C)-AR antagonists 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-aryl-7-methoxybenzofuran ([(11)C]MBF) and acridin-9-yl-[4-(4-methylpiperazin-1-yl)phenyl]amine ([(11)C]JP-1302) as α(2C)-AR-selective positron emission tomography (PET) probes. The radiochemical yield, specific activity, and radiochemical purity of these probes was appropriate for injection. To evaluate whether the brain penetration of these probes is related to the function of two major drug efflux transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), we performed PET studies using wild-type and P-gp/Bcrp knockout mice. In wild-type mice, the radioactivity level after injection with [(11)C]MBF initially increased and effluxed immediately from the brain, whereas that with [(11)C]JP-1302 was distributed throughout the brain. However, the regional distribution of radioactivity after injection with [(11)C]JP-1302 in the brain was different from that of α(2C)-ARs. In P-gp/Bcrp knockout mice, uptake of [(11)C]MBF was approximately 3.7-fold higher and that of [(11)C]JP-1302 was approximately 1.6-fold higher than those in wild-type mice. These results indicate that brain penetration of the two PET probes was affected by modulation of P-gp and Bcrp functions.
Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in north america† (1998)

In some, but not all countries, porphyria cutanea tarda (PCT) has been associated with chronic infection with the hepatitis C virus (HCV). Recently, PCT has also been associated with mutations in the HFE gene that are associated with HLA-linked hereditary hemochromatosis. Until now, few studies of these associations have been reported from North America. The aims of this study were: 1) to assess the prevalence of HCV infection and HFE mutations in North American patients with PCT; 2) to compare demographic and laboratory features between those who are HCV-positive and HCV-negative; and 3) to study urinary porphyrin excretions in American HCV-positive patients without clinically manifest PCT. Clinical and laboratory data, including tests for HCV and urinary porphyrins, were collected from 70 unselected patients with typical PCT. Urinary porphyrins were also measured in 110 non-PCT patients with chronic hepatitis C. Mutational analyses of the HFE gene were performed in 26 PCT patients. Thirty-nine of 70 (56%) of the PCT patients had evidence of HCV infection. Thirty-two of 39 PCT patients with HCV were men, all of whom used alcohol. In contrast, 22 of 31 PCT patients without HCV infection were women, 12 of whom had taken estrogens. The HCV-positive group was more likely to have used illicit intravenous drugs (45% vs. 0%; P = 0.01), to have had several (>4) sex partners (48% vs. 13%; P = 0.005), and less likely to have no known risk factors for HCV infection (33% vs. 78%; P = 0.004). Total urinary porphyrin excretion was the same in the two groups, but those with HCV infection had a significantly lower percentage of uroporphyrin and higher percentages of hepta-and hexa-carboxy porphyrins in urine. Sixteen of 110 (15%) HCV-positive subjects without PCT had increased urinary porphyrins, but, unlike PCT, these were mainly coproporphyrin. Forty-two percent of PCT patients carried the C282Y mutation of HFE (15% homozygous), and another 31% carried the H63D mutation (8% homozygous). Thus, 73% of PCT patients had one of these mutations. The prevalence of HCV infection (56%) and mutations in the HFE gene (73%) are high among North American patients with PCT. Alcohol and estrogen use are important additional risk factors. All PCT patients should be tested for HCV infection and for HFE gene mutations. Although HCV infection is a trigger for PCT, preclinical PCT is rare in chronic HCV hepatitis C in the United States.
Strategies for dynamic load balancing on highly parallel computers (1993)

Dynamic load balancing strategies for minimizing the execution time of single applications running in parallel on multicomputer systems are discussed. Dynamic load balancing (DLB) is essential for the efficient use of highly parallel systems when solving non-uniform problems with unpredictable load estimates. With the evolution of more highly parallel systems, centralized DLB approaches which make use of a high degree of knowledge become less feasible due to the load balancing communication overhead. Five DLB strategies are presented which illustrate the tradeoff between 1) knowledge - the accuracy of each balancing decision, and 2) overhead - the amount of added processing and communication incurred by the balancing process. All five strategies have been implemented on an Inter iPSC/2 hypercube.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Melanotropins as Growth Factors<sup>a</sup> (1993)

Peptides that regulate the growth of tissues, whether in a positive or negative manner, are termed growth factors. The melanocortins, neurotrophic sequences that correspond to peptide fragments contained within ACTH-(1-13), beneficially affect neural growth during development and regeneration. Analogues of ACTH-(4-9) (Org 2766) and ACTH-(4-10) (BIM 22015) are capable of sustaining neurite outgrowth from cultured dorsal root ganglion and spinal cord cells in the absence of nerve growth factor. The development of sexually dimorphic behavior in both male and female rats is influenced by perinatal administration of ACTH. This change appears to be correlated with changes in the growth and metabolism of developing serotonergic and dopaminergic systems in the hypothalamic nuclei associated with male and female sexual behavior. Similar melanotropic influences are found in the developing neuromuscular system. Neuromuscular development is accelerated by perinatal administration of melanocortins, provoking both nerve and muscle to attain early maturation. However, the responding tissue varies pivotally with age: early in gestation, embryonic muscle is acutely sensitive to peptide exposure; but once innervation has occurred, only the developing nerve reacts to melanocortin treatment. Melanocortins have little if any effect on the normal, adult neuromuscular system. Following peripheral nerve injury or pathology, melanotropins once again become effective growth factors, accelerating and enhancing nerve regeneration and muscle reinnervation. Electrophysiological, morphological, biochemical, and functional tests all indicate that ACTH-(4-10), Org 2766, BIM 22015, and alpha-MSH improve various facets of nerve regeneration, the degree to which the specific parameter is improved being dependent on the peptide fragment, its dosage, and pattern of administration. BIM 22015, while less effective as a neurotrophic factor, has potent myotrophic effects that the other peptides lack. Org 2766 may provide some protective action to the injured CNS as demonstrated by tests of cognitive function following brain lesions, although evaluation of recovery is sometimes enigmatic. Recovery from destruction of the nigrostriatal system is more easily measured through tests of motor function and open field behavior, both of which support a protective role for Org 2766. Compensatory mechanisms, including the presence of increased tyrosine hydroxylase and greater density of dopaminergic fibers, may be involved. Melanocortins are effective growth factors in sciatic nerve regeneration in neonatal rats. Both alpha-MSH and ACTH-(4-10) favor the formation of morphologically normal end plates despite the trauma following nerve crush at postnatal day 2.(ABSTRACT TRUNCATED AT 400 WORDS)
Self Assembling Polymers as Polymersomes for Drug Delivery (2011)

Polymersomes are one of the most interesting and versatile architectures among various self assembled systems for drug delivery. The stability and ability to load both hydrophilic and hydrophobic molecules make them excellent candidates to use as drug delivery systems. They demand for certain physicochemical parameters; especially hydrophilic to hydrophobic block ratio of copolymer to form vesicular morphologies. Different amphiphilic copolymers as well as their architectures show differences in the requirement of hydrophilic to hydrophobic block ratio to form polymersomes with various types of morphologies. This review focuses on basic the aspects of polymersomes along with a series of copolymers employed for preparation of polymersomes and their potential applications as drug delivery systems.
Characteristics and Applications of Silicon Carbide Power Devices in Power Electronics (2010)

Characteristics and Applications of Silicon Carbide Power Devices in Power Electronics Silicon carbide materials, with its high mechanical strength, high thermal conductivity, ability to operate at high temperatures, and extreme chemical inertness to most of the electrolytes, are very attractive for high-power applications. In this paper, properties, advantages, and limitations of SiC and conventional Si materials are compared. Various applications, where SiC power devices are attractive, are discussed.
Dissecting the Pharmacophore of Curcumin. Which Structural Element Is Critical for Which Action? (2013)

The dietary phenolic curcumin (1a) is the archetypal network pharmacological agent, but is characterized by an ill-defined pharmacophore. Nevertheless, structure-activity studies of 1a have mainly focused on a single biological end-point and on a single structural element, the aliphatic bis-enoyl moiety. The comparative investigation of more than one end-point of curcumin and the modification of its aromatic region have been largely overlooked. To address these issues, we have investigated the effect of aromatic C-prenylation in the three archetypal structural types of curcuminoids, namely, curcumin itself (1a), its truncated analogue 2a (C5-curcumin), and (as the reduced isoamyl version) the tetrahydro derivative 3a, comparatively evaluating reactivity with thiols and activity in biochemical (inhibition of NF-κB, HIV-1-Tat transactivation, Nrf2 activation) and phenotypic (anti-HIV action) assays sensitive, to a various extent, to thia-Michael addition. Prenylation, a validated maneuver for bioactivity modulation in plant phenolics, had no effect on Michael reactivity, but was detrimental for all biological end-points investigated, dissecting thiol trapping from activity, while hydrogenation attenuated, but did not completely abrogate, the activity of 1a. The C5-curcuminoid 2a outperformed the natural product in all end-points investigated and was identified as a novel high-potency anti-HIV lead in a cellular model of HIV infection. Taken together, these observations show that Michael reactivity is a critical element of the curcumin pharmacophore, but also reveal a surprising sensitivity of bioactivity to C-prenylation of the vanillyl moiety.
FNET: A Quickly Deployable and Economic System to Monitor the Electric Grid (2007)

In a time where the electric grid has become a potential target for malicious attacks against homeland security, this paper presents a system that can detect and locate disturbances that have an impact the electric grid. The system presented is referred to as FNET which is short for "Internet-based Frequency Monitoring Network. " FNET uses frequency measurements taken from across the electric interconnection to detect and locate disturbances such as generator trips and load shedding. These events occur routinely (almost daily) under normal system conditions. In these circumstances, the electric grid and its components usually respond in a manner so as to preserve the grid's integrity. However, in a time where threats to homeland security can involve threats to the electric grid, such disturbances caused by malicious (and perhaps multiple) attacks can cascade leading to the collapse of the entire electric grid. The goal of this work is to show that FNET can be an invaluable tool for enhancing situational awareness of the country's electric infrastructure especially in situations where the preservation of homeland security is critical.
Stable-Member Mounted Instrument Environment Simulation Model Development (1972)

The equations of motion for the stable member of a threegimbal platform are presented [3]. These equations are combined with models of the three platform control loops to formulate a model for the system. The system model is simplified and a digital simulation is developed for studying the motion of the stable member under conditions of dynamic vehicle angular environment.
Constructing large and fast multi-level cell STT-MRAM based cache for embedded processors (2012)

MLC STT-MRAM (Multi-level Cell Spin-Transfer Torque Magnetic RAM), an emerging non-volatile memory technology, has become a promising candidate to construct L2 caches for high-end embedded processors. However, the long write latency limits the effectiveness of MLC STT-MRAM based L2 caches. In this paper, we address this limitation with two novel designs: Line Pairing (LP) and Line Swapping (LS). LP forms fast cachelines by re-organizing MLC soft bits which are faster to write. LS dynamically stores frequently written data into these fast cachelines. Our experimental results show that LP and LS improve system performance by 15% and reduce energy consumption by 21%.
Boundary control design for towed cables via backstepping (2003)

A boundary control design for towed cables via backstepping is presented. A towed cable model is discretized by the finite element method into n nodes. The boundary control law is designed using the states at the outer nodes as inputs to stabilize the states at the inner nodes, thus moving backwards to construct a controller that can stabilize all system states asymptotically. The boundary controller improves the transient dynamics, suppresses the vibrations and enables smooth tracking for the towed cable system. Simulation and numerical results are presented to validate the proposed boundary control law.
Gastrointestinal motility disorders in patients with diabetes mellitus (1995)

Disturbed gastric and small intestinal motility is an often overlooked clinical problem. Delayed gastric emptying of liquid and/or solid food in patients with type 1 and type 2 diabetes (gastroparesis diabeticorum) occurs in approximately 50% of the patients. Also, the interdigestive gastric and small intestinal motility is often affected. There is only a weak correlation between symptoms and objectively measurable motor disturbances. Patients with severe upper gastrointestinal symptoms usually have disturbed motility, but most patients with impaired motility are asymptomatic. Recent studies have clearly shown that, in addition to autonomic neuropathy, acute metabolic derangements are likely to contribute to disturbed motility. Elevated glucose levels impair gastric and small intestinal motility during fasting and after food intake. Hyperinsulinemia per se has effects similar to hyperglycaemia on the stomach and small bowel, and may be a mediator of the effects of hyperglycaemia in healthy subjects. The impact of insulin on motility in diabetic patients is still unclear. Treatment of the gastric motility disorder should include a stabilization of gastric emptying. Different therapeutic modes may be useful, e.g. application of prokinetic drugs and optimizing the metabolic situation.
Standardization of an in vitro red blood cell test for evaluating the acute cytotoxic potential of tensides. (1990)

A new bovine red blood cell (RBC) test is presented as a biological in vitro assay for rapid assessment of the membrane and protein damaging effects of tensides. The system uses the hemoglobin released during RBC damage as an indicator to determine quantitatively the concentration at which the tensioactive agents affect and disrupt the plasma membrane. The spectrophotometric assay also considers the denaturation of hemoglobin caused by high concentrations of the tensides. Thus besides the halfmaximal concentrations to cause hemolysis (H50), a denaturation index (DI in %) can be determined for each test agent. The RBC assay was validated by assessing the H50 and DI for 30 randomly selected tensioactive agents from various sources and comparing the in vitro effects with their local irritant activity as assessed by the Draize test in the conjuntiva of conscious rabbits. The relationship between H50 and DI values, expressed as the lysis/denaturation ratio, was found to give a ranking order that best characterized the membrane damaging potency of the agents tested. Tensides known to possess ocular irritancy in the Draize test were characterized by a low lysis/denaturation ratio.
Creep Behavior and Mechanical Properties of Carbon Fiber Nano-Composites (2011)

In recent years, it has been observed that surface modification of carbon nanotubes（CNTs）influences on CNT’s distribution among epoxy resin and affects the mechanical properties of CNTs. Accordingly, the treatment of CNTs to with organic acids to oxidize them generates functional groups on the surface of CNTs. This investigation studies the consequent enhancement of the mechanical properties of CNTs. The influence of adding various proportions of CNTs to the epoxy resin on the mechanical properties of the composites thus formed is investigated, and the strength of the material is tested at different temperatures. The creep behaviors of carbon fiber (CF) /epoxy resin thermosetting composites and CNTs/CF/ epoxy resin composites were tested and analyzed at different stresses, orientations of fiber, temperatures and humidities. The creep exhibits only two stages- primary creep and steady-state creep. The effects of creep stress, creep time, and humidity on the creep of composites that contain various proportion of CNTs were investigated at various temperatures. Additionally, increasing the number of cycles in cyclic creep tests at room temperature resulted in a decrease in creep strain even at a high temperature of 55°C. Possible room temperature creep mechanisms have been proposed and discussed. With increasing number of creep tests, the creep strain decreased due to strain hardening which occurred during creep. Creep strain is believed to increase with applied stress, creep time, humidity, temperature and degree of the angle θ between the orientation of fiber and the direction of the applied stress. Moreover, the test results of creep strain of CF/epoxy resin composites and CNTs/CF/epoxy resin composites tested under various conditions can be smoothly fitted by the fitting curves of Findley power law. Finally, the test results also indicate that mechanical strength increase with the amount of CNTs added to the composites. Different coefficients of expansion of the matrix, fiber and CNTs, are such that overexpansion of the matrix at high temperature results in cracking in it. An SEM image of the fracture surface reveals debonding and the pulling out of longitudinal fibers because of poor interfacial bonding between fiber and matrix, which reduce overall strength.
Rapid Detection of Enterovirus RNA in Cerebrospinal Fluid Specimens with a Novel Single-Tube Real-Time Reverse Transcription-PCR Assay (2001)

A single-tube real-time reverse transcription-PCR (RT-PCR) assay for enterovirus detection in cerebrospinal fluid (CSF) was developed based on a fluorogenic probe and primers directed to highly conserved sequences in the 5' untranslated region of the enterovirus genome. Quantitative detection of enterovirus genome was demonstrated in a linear range spanning at least 5 logs. Endpoint titration experiments revealed that the in-tube detection limit of the assay was 11.8 enterovirus genome equivalents (95% detection rate) corresponding in our current extraction protocol to 592 enterovirus genome equivalents per ml of CSF. Twenty CSF specimens not suspected of viral meningitis were all found to be negative, and no cross-reactivity with herpes simplex virus type 1 and type 2, varicella-zoster virus, rhinovirus type 53, and influenza viruses A and B was observed. Nineteen CSF specimens from 70 patients suspected of viral meningitis were determined to be positive by PCR (27.1%), whereas only 17 were found to be positive by viral culture (24.3%). The sensitivity of the assay was 100% and the specificity was 96.2% compared to viral culture. Data from the real-time RT-PCR assay were available within 4 h. Our data suggest that the novel real-time RT-PCR assay may offer a reliable but significantly faster alternative to viral culture. Owing to the elimination of postamplification detection steps, its conduct required considerably less hands-on time and was associated with a substantially reduced carryover risk compared to previously described PCR-based enterovirus detection assays.