gebhart/patrepeval huggingface dataset:
Parallel Analysis of Two Analytes in Solutions or on Surfaces by Using a Bifunctional Aptamer: Applications for Biosensing and Logic Gate Operations (2007)

A bifunctional aptamer that includes two aptamer units for cocaine and adenosine 5'-monophosphate (AMP) is blocked by a nucleic acid to form a hybrid structure with two duplex regions. The blocked bifunctional aptamer assembly is used as a functional structure for the simultaneous sensing of cocaine or AMP. The blocked bifunctional aptamer is dissociated by either of the two analytes, and the readout of the separation of the sensing structure is accomplished by a colorimetric detection, by a released DNAzyme, or by electronic means that use Faradaic impedance spectroscopy or field-effect transistors. In one configuration, the blocked bifunctional aptamer structure is separated by the substrates cocaine or AMP, and the displaced blocker units act as a horseradish peroxidase-mimicking DNAzyme that permits the colorimetric detection of the analytes. In the second system, the blocked bifunctional aptamer hybrid is associated with a Au electrode. The displacement of the aptamer by any of the substrates alters the interfacial electron transfer resistance at the electrode surface, thus providing an electronic signal for the sensing process. In the third configuration, the blocked aptamer hybrid is linked to the gate of a field-effect transistor device. The separation of the complex by means of any of the analytes, cocaine, or AMP alters the gate potential, and this allows the electronic transduction of the sensing process by following the changes in the gate-to-source potentials. The different systems enable not only the simultaneous detection of the two analytes, but they provide a functional assembly that performs a logic gate "OR" operation.
The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane (1999)

Recently, we have provided evidence that the ABC-transporter MDR1 P-glycoprotein translocates analogs of various lipid classes across the apical plasma membrane of polarized LLC-PK1 cells transfected with MDR1 cDNA. Here, we show that expression of the basolateral ABC-transporter MRP1 (the multidrug resistance protein) induced lipid transport to the exoplasmic leaflet of the basolateral plasma membrane of LLC-PK1 cells at 15 degreesC. C6-NBD-glucosylceramide synthesized on the cytosolic side of the Golgi complex, but not C6-NBD-sphingomyelin synthesized in the Golgi lumen, became accessible to depletion by BSA in the basal culture medium. This suggests the absence of vesicular traffic and direct translocation of C6-NBD-glucosylceramide by MRP1 across the basolateral membrane. In line with this, transport of the lipid to the exoplasmic leaflet depended on the intracellular glutathione concentration and was inhibited by the MRP1-inhibitors sulfinpyrazone and indomethacin, but not by the MDR1 P-glycoprotein inhibitor PSC 833. In contrast to the broad substrate specificity of the MDR1 P-glycoprotein, MRP1 selectively transported C6-NBD-glucosylceramide and C6-NBD-sphingomyelin, the latter only when it was released from the Golgi lumen by brefeldin A. This shows the specific nature of the lipid translocation. We conclude that the transport activity of MDR1 P-glycoprotein and MRP1 must be taken into account in studies on the transport of lipids to the cell surface.
A Novel Retinoic Acid Receptor β Isoform and Retinoid Resistance in Lung Carcinogenesis (2005)

Restoration of RARbeta1' expression may overcome retinoid resistance in lung carcinogenesis.
Deep Image Compositing (2021)

Image compositing is a task of combining regions from different images to compose a new image. A common use case is background replacement of portrait images. To obtain high quality composites, professionals typically manually perform multiple editing steps such as segmentation, matting and foreground color decontamination, which is very time consuming even with sophisticated photo editing tools. In this paper, we propose a new method which can automatically generate high-quality image compositing with-out any user input. Our method can be trained end-to-end to optimize exploitation of contextual and color information of both foreground and background images, where the com-positing quality is considered in the optimization. Specifically, inspired by Laplacian pyramid blending, a dense-connected multi-stream fusion network is proposed to effectively fuse the information from the foreground and back-ground images at different scales. In addition, we intro-duce a self-taught strategy to progressively train from easy to complex cases to mitigate the lack of training data. Experiments show that the proposed method can automatically generate high-quality composites and outperforms existing methods both qualitatively and quantitatively.
HyCache+: Towards Scalable High-Performance Caching Middleware for Parallel File Systems (2014)

The ever-growing gap between the computation and I/O is one of the fundamental challenges for future computing systems. This computation-I/O gap is even larger for modern large scale high-performance systems due to their state-of-the-art yet decades long architecture: the compute and storage resources form two cliques that are interconnected with shared networking infrastructure. This paper presents a distributed storage middleware, called HyCache+, right on the compute nodes, which allows I/O to effectively leverage the high bi-section bandwidth of the high-speed interconnect of massively parallel high-end computing systems. HyCache+ provides the POSIX interface to end users with the memory-class I/O throughput and latency, and transparently swap the cached data with the existing slow speed but high-capacity networked attached storage. HyCache+ has the potential to achieve both high performance and low cost large capacity, the best of both worlds. To further improve the caching performance from the perspective of the global storage system, we propose a 2-phase mechanism to cache the hot data for parallel applications, called 2-Layer Scheduling (2LS), which minimizes the file size to be transferred between compute nodes and heuristically replaces files in the cache. We deploy HyCache+ on the IBM Blue Gene/P supercomputer, and observe two orders of magnitude faster I/O throughput than the default GPFS parallel file system. Furthermore, the proposed heuristic caching approach shows 29X speedup over the traditional LRU algorithm.
Reconstruction of 3D models from intensity images and partial depth (2004)

This paper addresses the probabilistic inference of geometric structures from images. Specifically, of syn-thesizing range data to enhance the reconstruction of a 3D model of an indoor environment by using video images and (very) partial depth information. In our method, we interpolate the available range data us-ing statistical inferences learned from the concurrently available video images and from those (sparse) regions where both range and intensity information is avail-able. The spatial relationships between the variations in intensity and range can be efficiently captured by the neighborhood system of a Markov Random Field (MRF). In contrast to classical approaches to depth re-covery (i.e. stereo, shape from shading), we can af-ford to make only weak prior assumptions regarding specific surface geometries or surface reflectance func-tions since we compute the relationship between exist-ing range data and the images we start with. Experimen-tal results show the feasibility of our method.
Induction of HIV-1 Replication in Latently Infected CD4+ T Cells Using a Combination of Cytokines (1998)

Although it has been demonstrated that certain cytokines, particularly proinflammatory cytokines, can enhance ongoing viral replication in peripheral blood mononuclear cells (PBMCs) of HIV-1-infected individuals, it is unclear what role these cytokines play in the induction of HIV-1 replication in latently infected, resting CD4(+) T cells. This study demonstrates that the in vitro combination of the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha together with the immunoregulatory cytokine IL-2 are potent inducers of viral replication in highly purified, latently infected, resting CD4+ T cells derived from HIV-infected individuals who are antiretroviral therapy-naive as well as those who are receiving highly active antiretroviral therapy (HAART). Viral replication induced by this combination of cytokines was completely suppressed in the presence of HAART in vitro. Given that an array of cytokines, including IL-6, TNF-alpha, and IL-2, are copiously expressed in the microenvironment of the lymphoid tissues, which harbor the latent viral reservoirs, induction of HIV by this combination of cytokines may in part explain the commonly observed reappearance of detectable plasma viremia in HIV-infected individuals in whom HAART was discontinued. Moreover, since it is likely that these infected cells die upon activation of virus and that HAART prevents spread of virus to adjacent cells, the observation that this combination of cytokines can markedly induce viral replication in this reservoir may have important implications for the activation-mediated diminution of the latent reservoir of HIV in patients receiving HAART.
Functionalization of Single-Wall Carbon Nanotubes by Tandem High-Pressure/Cr(CO)<sub>6</sub> Activation of Diels−Alder Cycloaddition (2006)

An original method to induce Diels-Alder cycloadditions on carbon nanotubes is reported. The process is based on the double activation of the nanotube surface by combining high pressure and Cr(CO)6. This allows the efficient functionalization of carbon nanotubes by electron-rich dienes.
Cloning and sequence analysis of a novel hemolysin gene (vllY) from Vibrio vulnificus (1997)

A gene (vllY) encoding a novel hemolysin of Vibrio vulnificus CKM-1 has been cloned and sequenced. When the vllY gene was expressed in minicells, a unique peptide of approximately 40 kDa was identified. Subcellular fractionation of Escherichia coli cells carrying the vllY gene indicated that the VllY protein was distributed in both the cytoplasmic and the periplasmic fractions, with the notable ability to appear in the latter compartment. Nucleotide sequence analysis predicted a single open reading frame of 1,071 bp encoding a 357-amino acid polypeptide with an estimated pI of 5.02. The deduced amino acid sequence of VllY showed high similarity to the sequence of legiolysin, responsible for hemolysis, pigment production, and fluorescence in Legionella pneumophila. The enzyme also exhibited sequence homology to the MelA protein sequence of Shewanella colwelliana and the sequences of 4-hydroxyphenylpyruvate dioxygenase family proteins from various organisms. PCR screening and Southern blotting of V. vulnificus strains revealed that all of the 41 V. vulnificus clinical isolates contained vllY-like genes.
Selective Synthesis of Fluoro-, Fluorohydro-, and Chlorofluorosilanes from Hydrosilanes with the Use of a CuCl<sub>2</sub>(CuI)/KF Reagent (1996)

A selective synthesis of fluoro-, fluorohydro-, and chlorofluorosilanes from hydrosilanes has been examined. The reaction of Me2PhSiH and MePh2SiH with a mixture consisting of 2 equiv of CuCl2, 1 equiv of KF, and a catalytic amount of CuI in THF at room temperature afforded Me2PhSiF and MePh2SiF in high yields, respectively. With slight modification of this reaction, n-Hex2SiHF, Ph2SiHF, MeMesSiHF, MePhSiHF, PhSiH2F, and PhSiHF2 could be readily prepared from the corresponding polyhydrosilanes selectively in high yields. Treatment of MePhSiHF and Ph2SiHF with 2 equiv of CuCl2 in the presence of a catalytic amount of CuI afforded the respective chlorofluorosilanes, MePhSiClF and Ph2SiClF.
Microstrip diplexers design with common resonator sections for compact size, but high isolation (2006)

High isolation and compact size microstrip diplexers designed with common resonator sections have been proposed. By exploiting the variable frequency response of the stepped-impedance resonator, resonators can be shared by the two filter channels of the desired diplexer if their fundamental and the first spurious resonant frequency are properly assigned. Size reduction are, therefore, achieved by introducing a few common resonator sections in the circuit. This concept has been verified by the experimental results of two diplexer circuits. One of the diplexers is composed of two three-pole parallel-coupled bandpass filters and the other is composed of two four-pole cross-coupled bandpass filters, which are formed by only five and six resonators, respectively. Both of them occupy extremely small areas while still keeping good isolations. Good agreements are also achieved between measurement and simulation.
Epilepsy and Seizure Classification in 63 Dogs: A Reappraisal of Veterinary Epilepsy Terminology (1999)

The human definitions of epilepsy and seizure classification were applied rigidly to epileptic dogs to investigate whether the distribution of the seizure types and epilepsies of dogs is comparable to that of human beings. Sixty-three dogs were referred because of recurrent (> 2) epileptic seizures. Only dogs without previous or ongoing antiepileptic treatment were included. All dogs had a physical and neurologic examination and blood work that included a CBC and a biochemical profile. All owners were asked to complete a questionnaire, focusing on seizure development. In addition, video recordings of suspected seizure episodes were analyzed if available. In the majority of dogs where an intracranial lesion was suspected, a computerized tomography scan was performed. Sixty-five percent of the dogs experienced partial seizures with or without secondary generalization and 32% exhibited primary generalized seizures; in 3% of the dogs the seizures could not be classified. Twenty-five percent of these cases were classified as idiopathic, 16% as symptomatic, and 45% as cryptogenic epilepsy; in 14% of these a classification was not possible. Applying human definitions, the distribution of seizure types and epilepsy classifications in these dogs differed widely from those in previous reports of canine epilepsy, where generalized seizures and idiopathic epilepsy were most frequently reported. However, our findings are consistent with the results of several large studies of human epilepsy patients. In dogs with epilepsy, closer attention must be given to the detection of a partial onset of seizures. In this study, detailed questioning of the owners and when possible analysis of video recorded seizures, proved to be sufficient for diagnosing seizures with a partial onset in a significant number of dogs. Partial onset of seizures may be an indication of underlying cerebral pathology. Some adjustments of veterinary epilepsy terminology are suggested.
Carbohydrate specificity of a galectin from chicken liver (CG-16) (2001)

Owing to the expression of more than one type of galectin in animal tissues, the delineation of the functions of individual members of this lectin family requires the precise definition of their carbohydrate specificities. Thus, the binding properties of chicken liver galectin (CG-16) to glycoproteins (gps) and Streptococcus pneumoniae type 14 polysaccharide were studied by the biotin/avidin-mediated microtitre-plate lectin-binding assay and by the inhibition of lectin–glycan interactions with sugar ligands. Among 33 glycans tested for lectin binding, CG-16 reacted best with human blood group ABO (H) precursor gps and their equivalent gps, which contain a high density of d-galactopyranose(β1–4)2-acetamido-2-deoxy-d-glucopyranose [Gal(β1–4)GlcNAc] and Gal(β1–3)GlcNAc residues at the non-reducing end, but this lectin reacted weakly or not at all with A-,H-type and sialylated gps. Among the oligosaccharides tested by the inhibition assay, the tri-antennary Gal(β1–4)GlcNAc (Tri-II) was the best. It was 2.1×103 nM and 3.0 times more potent than Gal and Gal(β1–4)GlcNAc (II)/Gal(β1–3)GlcNAc(β1–3)Gal(β1–4)Glc (lacto-N-tetraose) respectively. CG-16has a preference for the β-anomer of Gal at the non-reducing end of oligosaccharides with a Gal(β1–4) linkage &gt;Gal(β1–3)Gal(β1–6). From the results, it can be concluded that the combining site of this agglutinin should be a cavity type, and that a hydrophobic interaction in the vicinity of the binding site for sugar accommodation increases the affinity. The binding site of CG-16 is as large as a tetrasaccharide of the β-anomer of Gal, and is most complementary to lacto-N-tetraose and Gal(β1–4)GlcNAc related sequences.
Nanoelectrokinetic purification device for a continuous peritoneal dialysate recycler (2017)

Ion concentration polarization (ICP) phenomenon has been extensively researched for electro-desalination and purification applications because of its efficient capability of separating any charged species from brines. In this work, the ICP purifier, for the first time, was applied for a novel continuous peritoneal dialysate recycler. Most of charged hazardous substances were sufficiently removed by conventional ICP mechanisms. Moreover, slightly charged toxic molecule (creatinine) was mostly eliminated through nanoporous membrane, and uncharged toxic molecule (urea) was perfectly decomposed by electrochemical reactions. Based on the combined removal mechanisms confirmed in a micro/nanofluidic platform, a macro ICP purifier was finally demonstrated for practical applicability. We would expect significant advances in a quality of life for chronic kidney disease patients by this ICP purifier.
Source Free Transfer Learning for Text Classification (2014)

Transfer learning uses relevant auxiliary data to help the learning task in a target domain where labeled data is usually insufficient to train an accurate model. Given appropriate auxiliary data, researchers have proposed many transfer learning models. How to find such auxiliary data, however, is of little research so far. In this paper, we focus on the problem of auxiliary data retrieval, and propose a transfer learning framework that effectively selects helpful auxiliary data from an open knowledge space (e.g. the World Wide Web). Because there is no need of manually selecting auxiliary data for different target domain tasks, we call our framework Source Free Transfer Learning (SFTL). For each target domain task, SFTL framework iteratively queries for the helpful auxiliary data based on the learned model and then updates the model using the retrieved auxiliary data. We highlight the automatic constructions of queries and the robustness of the SFTL framework. Our experiments on 20NewsGroup dataset and a Google search snippets dataset suggest that the framework is capable of achieving comparable performance to those state-of-the-art methods with dedicated selections of auxiliary data.
Practical aspects of epidural and intrathecal narcotic analgesia in the intensive care setting. (1989)

The administration of epidural and intrathecal narcotics is a technique of providing postoperative analgesia that is gaining popularity in many operating rooms, labor suites, and intensive care units. The epidural and intrathecal methods, first introduced a century ago, have been implemented as additional techniques for the administration of narcotic analgesics. Patients who have received epidural or intrathecal narcotics are frequently admitted to the intensive care unit for postoperative care. Because of their continuous proximity to the patient and their monitoring skills, critical care nurses are able to evaluate the analgesic effect and intervene in the event of a complication.
Relationships between Colony Morphotypes and Oil Tolerance in <i>Rhodococcus rhodochrous</i> (2000)

A mucoidal strain of Rhodococcus rhodochrous was resistant to 10% (vol/vol) n-hexadecane, while its rough derivatives were sensitive. When the extracellular polysaccharide (EPS) produced by the mucoidal strain was added to cultures of the rough strains, the rough strains gained resistance to n-hexadecane. Thus, EPS confer tolerance to n-hexadecane in members of the genus Rhodococcus.
RadioDoc review: Developing critical theory of the radio documentary and feature form (2014)

In 2013, the author founded an online journal, RadioDoc Review, to develop critical theory of the radio documentary/feature form and define production and research excellence in this under-researched field. Its international editorial board, comprising eminent scholars, acclaimed practitioners and key industry figures, selects audio works to be co-reviewed each volume. RadioDoc Review Volume 1 (2014) contains 31,000 words of ground-breaking analysis of the radio documentary/feature form, disseminated under the University of Wollongong's Open Access policy. Via promotion on social media, the journal has developed a significant international following, and the expert reviews have fomented debate in radio studies and in areas as diverse as race, psychiatry and imperialism in Africa. This article describes the establishment of RadioDoc Review and analyses its role in filling a gap in radio scholarship.
Detinning of Scrap Tin Plate (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetinning of Scrap Tin PlateWilfred Scott and Nele DavisCite this: Ind. Eng. Chem. 1930, 22, 8, 910–911Publication Date (Print):August 1, 1930Publication History Published online3 December 2004Published inissue 1 August 1930https://pubs.acs.org/doi/10.1021/ie50248a601https://doi.org/10.1021/ie50248a601research-articleACS PublicationsRequest reuse permissionsArticle Views32Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Synthesis of cis-4-(phosphonooxy)-2-piperidinecarboxylic acid, an N-methyl-D-aspartate antagonist (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of cis-4-(phosphonooxy)-2-piperidinecarboxylic acid, an N-methyl-D-aspartate antagonistSheryl J. Hays, Thomas C. Malone, and Graham JohnsonCite this: J. Org. Chem. 1991, 56, 12, 4084–4086Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/jo00012a061https://doi.org/10.1021/jo00012a061research-articleACS PublicationsRequest reuse permissionsArticle Views644Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts