gebhart/patrepeval huggingface dataset:
The signal data explorer: a high performance grid based signal search tool for use in distributed diagnostic applications (2006)

We describe a high performance grid based signal search tool for distributed diagnostic applications developed in conjunction with Rolls-Royce plc for civil aero engine condition monitoring applications. With the introduction of advanced monitoring technology into engineering systems, healthcare, etc., the associated diagnostic processes are increasingly required to handle and consider vast amounts of data. An exemplar of such a diagnosis process was developed during the DAME project, which built a proof of concept demonstrator to assist in the enhanced diagnosis and prognosis of aero-engine conditions. In particular it has shown the utility of an interactive viewing and high performance distributed search tool (the signal data explorer) in the aeroengine diagnostic process. The viewing and search techniques are equally applicable to other domains. The signal data explorer and search services have been demonstrated on the Worldwide Universities Network to search distributed databases of electrocardiograph data.
Experimental demonstration of an all-optical routing node for multihop wavelength routed networks (1996)

Summary form only given. We have demonstrated an all-optical routing node for wavelength-routed networks. Subcarrier-header coded packets are correctly routed to a local host or converted to one of four wavelengths and routed to a waveguide array WDM device. Wavelength conversion at the packet rate of both 622 Mbps payload and 103 Mbps subcarrier multiplexed header at 3.9 GHz to four wavelengths is demonstrated.
Report of the New England association of chemistry teachers. (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReport of the New England association of chemistry teachers.B. B. CorsonCite this: J. Chem. Educ. 1947, 24, 3, 150Publication Date (Print):March 1, 1947Publication History Received3 August 2009Published online3 June 2016Published inissue 1 March 1947https://doi.org/10.1021/ed024p150Copyright © 2016 RIGHTS & PERMISSIONSArticle Views8Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (7 MB) Get e-Alerts Get e-Alerts
A High-Throughput Proteomic Approach Provides Distinct Signatures for Thyroid Cancer Behavior (2011)

Different proteomic signatures validate the distinction of classic and FVPTC and provide a practical clinical mechanism to predict the thyroid cancer behavior and stratify patients for clinical management.
Controllable Self-Assembly of Amphiphilic Dendrimers on a Silica Surface: The Effect of Molecular Topological Structure and Salinity (2016)

The adsorption kinetics and equilibrium of amphiphilic dendrimers based on poly(amidoamine) modified with a dodecyl chain, G<sub>n</sub>QPAMC<sub>12</sub> (n represents the generation number), with different generation numbers at a silica-water interface have been investigated. The effect of molecular shape with different charge characteristics on the adsorption kinetics, adsorption isotherms, and the conformation of a self-assembled layer has been elucidated. For the adsorption kinetics, two steps were observed including the adsorption of individual molecules at concentrations below the critical micelle concentration (cmc) and the predominant adsorption of aggregates above the cmc. However, the adsorption isotherm, as a function of the generation number, presented an exceptional characteristic, in which a decrease in adsorption mass with different levels occurred in a high generation of amphiphilic dendrimers, depending on the balance of hydrophobic interaction and electrostatic repulsion. Atomic force microscopy imaging showed that flattened films with pores (spacing) of various shapes and roughness of 3-4 nm were formed, of which the pores (spacing) decreased obviously as the generation number increased. The addition of electrolyte (NaBr) has a great effect on the film morphology formed by the G<sub>3</sub>QPAMC<sub>12</sub> dendrimer adsorbed at the silica-water interface, showing that the film became closer with smaller pores with increased NaBr concentration.
Small form factor dual band (28/38 GHz) PIFA antenna for 5G applications (2017)

This paper presents for the first time, the design of a dual band PIFA antenna for 5G applications on a low-cost substrate with smallest form factor and widest bandwidth in both bands (28 GHz and 38 GHz). The proposed dual band PIFA antenna consists of a shorted patch and a modified U-shaped slot in the patch. The antenna shows good matching at and around both center frequencies. The antenna shows clean radiation pattern and bandwidth of 3.34 GHz and 1.395 GHz and gain of 3.75 dBi and 5.06 dBi at 28 and 38 GHz respectively. This antenna has ultra-small form factor of 1.3 mm × 1.2 mm. Patch is shorted at one end with a metallic cylindrical via. A CPW line and a feeding via are used on the bottom side of the substrate to excite the PIFA antenna patterned on the top side of the substrate which also facilitate the measurements of the antenna at mm-wave frequencies. The antenna was designed on low cost Isola FR406 substrate.
Fast maximum likelihood estimation of parameters in crowded signal environments (1993)

This dissertation is directed towards developing computationally efficient estimation algorithms whose performance are comparable to those of Maximum Likelihood (ML) estimators. Since the motivation for developing such algorithms is to be able to apply them to real-world problems, it is important that they work well even in crowded signal environments. The computational efficiency of these algorithms lies in reducing the multi-dimensional search involved in ML estimation into multiple one-dimensional searches. This is achieved by using our knowledge of the shape of the Compressed Likelihood Function (CLF) in the parameter space. The attributes of this shape may vary because the signal model is different for different problems. However, in many problems the global maximum can be shown to be situated at specific intersections of the ridges of the CLF. In some signal models, it may be difficult to characterize the shape of the CLF for multiple components. For such models, we propose an iterative estimation method that decomposes the original data into its constituent signal components and estimates the parameters of the individual components efficiently using our knowledge of the shape of the CLF. In this dissertation, estimation algorithms for three specific signal models are developed--undamped sinusoids, exponentially damped sinusoids, and hyperbolic frequency modulated signals. The algorithms developed in this dissertation are applied to the analysis of two real-world data sets: (i) Nuclear Magnetic Resonance (NMR) spectroscopy data of the human blood plasma and (ii) Active sonar reverberation data.
Development of functional responses in human exocrine pancreas. (1980)

The ability of newborns to digest proteins, fats, and carbohydrates depends, to a large extent, on their level of exocrine pancreatic function. Building on the limited published data, we studied pancreatic enzyme activities in the duodenal fluid and the response of the exocrine pancreas to secretogogues in 15 premature and full-term infants at birth and at 30 days of age. We compared these findings to those obtained from identical studies of 17 children age 2 years and above. In addition, we measured the pancreatic exopeptidase, carboxypeptidase B, in relation to other pancreatic enzymes. The duodenal fluid of newborns and infants contained no amylase and negligible lipase. Carboxypeptidase B levels were also low compared to those in the older children. In contrast, chymotrypsin activity in infants was about 50% to 60% of level found in the older children. Trypsin activity, the highest of all the enzymes measured, was about the same in both newborns and older children, with a transient increase at 30 days. Administration of pancreozymin had no effect on pancreatic enzymes in the duodenal fluid of newborns and a slight effect on 1-month-old infants. But by age 2 years, a full response of the pancreas to pancreozymin was evident. In infants and newborns, responses to secretin were poor. Thus, the secretory response of the human pancreas to secretogogues, absent or minimal at birth, is acquired during the postnatal period.
Nonaminergic striatal neurons convert exogenous l‐dopa to dopamine in parkinsonism (1980)

In intact striatum, the enzyme dopa decarboxylase is localized predominantly in dopaminergic nerve terminals. In Parkinson disease, loss of dopaminergic neurons is associated with massive depletion of striatal decarboxylase activity. Nevertheless, efficacy of exogenous L-dopa in parkinsonism is generally believed to result from its enzymatic decarboxylation to dopamine in the corpus striatum. It has previously been suggested that, after degeneration of nigrostriatal pathways, decarboxylation of administered L-dopa may occur mainly at such striatal sites as surviving dopaminergic terminals, serotonergic neurons, or capillaries; but currently available data do not favor these hypotheses. Recent experimental studies indicate that a substantial amount of decarboxylase activity is localized in striatal interneurons or efferent neurons that may not normally synthesize monoamines. We propose that after depletion of dopaminergic terminals, these nonaminergic striatal neurons may contain a large fraction of residual dopa decarboxylase activity and may represent an important locus for conversion of administered dopa to functional dopamine in the parkinsonian corpus striatum.
Comparative Evaluation of Four Phenotypic Tests for Detection of Carbapenemase-Producing Gram-Negative Bacteria (2016)

Four screening assays aimed for rapid detection of carbapenemase production from Gram-negative bacterial isolates, i.e., the Neo-Rapid Carb kit (Rosco Diagnostica A/S), the Rapidec Carba NP test (bioMérieux SA), the β Carba test (Bio-Rad Laboratories N.V.), and a homemade electrochemical assay (BYG Carba test) were evaluated against a panel comprising 328 clinical isolates (Enterobacteriaceae [n = 198] and nonfermentative Gram-negative bacilli [n = 130]) with previously characterized resistance mechanisms to carbapenems. Among Enterobacteriaceae isolates, the BYG Carba test and the β Carba test showed excellent sensitivities (respectively, 100% and 97.3%) and specificities (respectively, 98.9% and 97.7%). The two other assays yielded poorer performances with sensitivity and specificity of 91.9% and 83.9% for the Rapidec Carba NP test and of 89.2% and 89.7% for the Neo-Rapid Carb kit, respectively. Among Pseudomonas spp., sensitivities and specificities ranged, respectively, from 87.3% to 92.7% and from 88.2% to 94.1%. Finally, all tests performed poorly against Acinetobacter spp., with sensitivities and specificities, respectively, ranging from 27.3% to 75.8% and from 75 to 100%. Among commercially available assays, the β Carba test appeared to be the most convenient for routine use and showed the best overall performances, especially against OXA-48-like producers. The excellent performance of the BYG Carba test against Enterobacteriaceae was confirmed (100% sensitivity and 98.9% specificity).
Synthetic membranes containing schardinger cyclodextrin additives (1981)

The permeation characteristics of the isomers of such aromatics as dichlorobenzenes, nitrochlorobenzenes, xylenes, etc., through a Methocel HG membrane containing various amounts of Schardinger α-cyclodextrin and β-cyclodextrin additives were measured in liquid/liquid dialysis and pervaporation experiments. The results showed that the cyclodextrins are able to selectively mediate molecular transport through the Methocel HG membranes. In general, increased membrane selectivity and a decrease in permeation rates were observed. Permeation rates for some aromatic compounds were decreased several hundred times with only 25% amounts of additive cyclodextrins in the Methocel HG membranes. Concentration electrical potential and bi-ionic electrical potential in membranes containing the Schardinger cyclodextrin have been measured and also show that the cyclodextrins are able to induce ion transport selectively through nonionic membranes. Dynamic mechanical properties of Methocel HG membranes containing cyclodextrins suggest these additives to be antiplasticizing agents. A mechanism for the modification of the intrinsic membrane permeation properties by cyclodextrin additive involving antiplasticizing action by the additives plus induced tortuous diffusion, where the latter is a result of specific interactions between the cyclodextrin additive and the permeating molecules, is proposed.
Apoptotic index and apoptosis influencing proteins bcl‐2, mcl‐1, bax and caspases 3, 6 and 8 in pancreatic carcinoma (1998)

Both bcl-2 and bax influence the extent of apoptosis in pancreatic carcinoma. The strong expression of caspases 3, 6 and 8 in pancreatic carcinoma is evidence of the activation of the apoptotic machinery in malignant cells in pancreatic carcinoma and shows that the genes of these proteins are often upregulated in them.
Fast rotation search for real-time interactive point cloud registration (2014)

Our goal is the registration of multiple 3D point clouds obtained from LIDAR scans of underground mines. Such a capability is crucial to the surveying and planning operations in mining. Often, the point clouds only partially overlap and initial alignment is unavailable. Here, we propose an interactive user-assisted point cloud registration system. Guided by the system, the user's role is simply to identify and search for overlapping regions across the point clouds. Specifically, given two point sets, the user clicks on a point in one set, then simply hovers the mouse on the other set to find a matching point. Each mouse position gives rise to a translation, and our system instantly optimises the rotation that aligns the point clouds.
A KINETIC MODEL OF PHOSPHOLIPID TRANSLOCATION IN THE ERYTHROCYTE MEMBRANE (1995)

A mathematical model is presented to simulate transverse lipid movement in the human erythrocyte membrane from one membrane monolayer to the other. The model is based on a system of differential equations describing the time-dependence of phospholipid redistribution and the steady-state distribution. Different translocation mechanisms are considered in a combined way. These are the ATP-dependent carrier mediated translocation, the carrier mediated facilitated diffusion and carrier independent transbilayer diffusion. Using realistic values of model parameters the model allows calculation of the transbilayer motion and distribution of phospholipids of the human erythrocyte membrane for several biologically relevant conditions and different experimental conditions.
Quantification of low density lipoprotein and transferrin endocytic sorting in HEp2 cells using confocal microscopy (1994)

Numerous experiments on CHO cells have shown that endosomes are composed of separate vesicular and tubulovesicular compartments, such as the sorting endosome, the recycling compartment, and the late endosome. However, Hopkins et al. (Nature 346, 335-339, 1990) have reported that endosomes in HEp2 human carcinoma cells form an extensive tubular reticulum. To resolve their observations with previous results from CHO and other cells, we examined the sorting and intracellular transport of endocytosed macromolecules in HEp2 cells, using low density lipoprotein (LDL) and transferrin (Tf) to probe the lysosomally directed and recycling pathways, respectively. Fluorescent LDL and Tf were observed with laser scanning confocal microscopy to visualize simultaneously both probes' sorting and subsequent post-sorting behavior in HEp2 cells. Quantifying the 3-dimensional cellular distributions of fluorescent LDL and Tf, after a variety of pulsechase schemes, gave the ligands' trafficking rates. Initially, both ligands appear in the same punctate sorting endosomes, and fingers of Tf start extending from these sorting endosomes. Tf rapidly leaves dual-labeled sorting endosomes (t1/2 approximately 2.5 minutes) and enters a post-sorting recycling compartment from which it is recycled out of the cell (t1/2 approximately 7 minutes). We present both morphological and kinetic data supporting the existence of these two separate compartments along the recycling pathway in HEp2 cells. LDL remains in punctate sorting endosomes that eventually lose the ability to receive newly endocytosed LDL, and mature into late endosomes. The trafficking and sorting of Tf and LDL in HEp2 cells follow the same general scheme as in CHO cells, indicating that the tubular endosomes previously seen may be the tubular parts of the sorting endosomes and recycling compartments in these cells. We propose that the endosomes in the recycling pathway of HEp2 cells, as in CHO cells, are composed of short-lived sorting endosomes, accessible to both Tf and LDL, and long-lived post-sorting recycling compartments, which contain Tf and recycling receptors but not LDL.
Quinones and quinone methides. III. A novel side-chain amination reaction of 2-(1-Phenylethyl)-1,4-benzoquinones (1978)

2-Benzyl-5-methoxy-1,4-benzoquinones react as expected with morpholine to yield 2-phenylmorpholinomethylhydroquinones. However, 5-methoxy-2-(1-phenylethyl)-1,4-benzoquinones undergo a novel amination reaction at the ß-carbon atom of the alkyl group with the formation of 2- morpholino-3-phenylbenzofurans.
Effect of pH on the Stability of Plant Phenolic Compounds (2000)

It is not uncommon to treat plant-derived foods and feeds with alkali. Such exposure to high pH is being used to recover proteins from cereals and legumes, to induce the formation of fiber-forming meat analogue vegetable protein, for preparing peeled fruits and vegetables, and for destroying microorganisms. In addition to their profound effects on functional and nutritional properties in such foods, such treatments may also cause other side reactions, including the destruction of natural polyphenolic compounds. Because plants contain a large number of structurally different antioxidant, anticarcinogenic, and antimicrobial polyphenolic compounds, it is of interest to know whether such compounds are stable to heat and to high pH. In this model study, the stability of the following natural polyphenols to pH in the range 3-11 was studied with the aid of ultraviolet spectroscopy: caffeic acid, (-)-catechin, chlorogenic acid, ferulic acid, gallic acid, (-)-epigallocatechin, rutin, and the nonphenolic compound trans-cinnamic acid. This study demonstrates that caffeic, chlorogenic, and gallic acids are not stable to high pH and that the pH- and time-dependent spectral transformations are not reversible. By contrast, chlorogenic acid is stable to acid pH, to heat, and to storage when added to apple juice. (-)-Catechin, (-)-epigallocatechin, ferulic acid, rutin, and trans-cinnamic acid resisted major pH-induced degradation. The results are rationalized in terms of relative resonance stabilization of phenoxide ions and quinone oxidation intermediates. The possible significance of these findings to food chemistry and microbiology is discussed.
Localisation of metallothionein isoform mRNAs in rat hepatoma (H4) cells (1995)

The localisation of metallothionein isoform mRNAs in rat hepatoma (H4) cells was investigated using two approaches, namely Northern hybridisation of total RNA extracted from free, cytoskeletal‐bound and membrane‐bound polysomes isolated by a sequential detergent/salt extraction procedure and in situ hybridisation. The cytoskeletal‐bound polysomes were enriched in metallothionein‐I (MT‐I) and c‐myc mRNAs but showed a significantly lower enrichment in MT‐II mRNA. These findings indicate that the MT‐I mRNA is localised to the cytoskeleton during translation. In situ hybridisation using a biotin‐labelled oligonucleotide probe revealed a predominantly perinuclear localisation for the MT‐I mRNA.
Application of a Land Surface Model Using Remote Sensing Data for High Resolution Simulations of Terrestrial Processes (2013)

Most current land surface models (LSMs) coupled to regional climate models (RCMs) have been implemented at the several tens of kilometer spatial scales. Modeling land surface processes in LSMs at a finer resolution is necessary for improvements in terrestrial water and energy predictions especially for small catchments. This study has therefore assessed the applicability of high-resolution simulations for terrestrial processes to a small study basin from the Common Land Model (CoLM) using 1-km surface boundary conditions (SBCs) based on remote sensing products. The performance of the CoLM simulations at finer (1-km) and coarser (30-km) resolutions are evaluated for daily runoff and land surface temperature results which have a significant influence on the terrestrial water and energy cycles. The daily stream water temperature is also estimated by a linear regression function of the 1-km daily land surface temperature prediction. The daily stream runoff and temperature results are compared with observations from a stream gauge station, and the daily land surface temperature prediction is compared with the 1-km remote sensing product. It is observed that the high-resolution CoLM results can reasonably capture seasonal variations in both daily runoff and temperatures crucial to the terrestrial water and energy budget.
Split‐Gate Organic Field‐Effect Transistors for High‐Speed Operation (2014)

Split-gate organic field-effect transistors have been developed for high-speed operation. Owing to the combination of reduced contact resistance and minimized parasitic capacitance, the devices have fast switching characteristics. The cutoff frequencies for the vacuum-evaporated devices and the solution-processed devices are 20 and 10 MHz, respectively. A speed of 10 MHz is the fastest device reported so far among solution-processed organic transistors.
Using Video Prompting to Teach Cooking Skills to Secondary Students with Moderate Disabilities (2005)

Three secondary students with moderate disabilities acquired cooking skills through a constant time delay procedure used with video prompting. A multiple probe design was used to evaluate effectiveness of the procedure to teach preparation of a food item (a) on a stove, (b) in a microwave, and (c) on a counter top. The procedure was effective for each student. Guidelines for using videotapes in the instruction of functional skills are discussed.
A Digital Audio Time Base Corrector for Linear Magnetic Recording (1985)

The marketplace acceptance of component television and high-fidelity video cassette recorders signals a significant consumer interest in high quality audio for television. Unfortunately, many of the video tape recorders in present use are incapable of providing satisfactory audio reproduction due to a variety of inherent mechanical limitations.