gebhart/patrepeval huggingface dataset:
Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes (2006)

During cardiac muscle development, most cardiomyocytes permanently withdraw from the cell cycle. Previously, by suppressive subtractive hybridization, we identified calcyclin-binding protein/Siah-interacting protein (CacyBP/SIP) as one of the candidates being upregulated in the hyperplastic to hypertrophic switch, suggesting an important role of CacyBP/SIP in cardiac development. To show the importance of CacyBP/SIP during myoblast differentiation, we report here that CacyBP/SIP is developmentally regulated in postnatal rat hearts. The overexpression of CacyBP/SIP promotes the differentiation and DNA synthesis of H9C2 cells and primary rat cardiomyocytes, as well as downregulates the expression of beta-catenin. Besides, CacyBP/SIP promotes the formation of myotubes and multinucleation upon differentiation. To investigate the cardioprotective role of CacyBP/SIP in cardiomyocytes, a hypoxia/reoxygenation model was employed. We found that CacyBP/SIP was upregulated during myocardial infarction (MI) and hypoxia/reoxygenation. As a conclusion, CacyBP/SIP may play a role in cardiomyogenic differentiation and possibly protection of cardiomyocytes during hypoxia/reoxygenation injury.
Keto-Aldehydes and Cell Division (1967)

Many problems are left open in this article. Its publication may be excused by the suffering cancer causes, which urges the researcher to publish as soon as he thinks he may have found a new trail, which also may be taken by others. What emerges clearly is that SH groups, with their specific reactivities, offer a hopeful target in the search for cancerostatic substances, among which the natural repressor of cell division may hold out the most promise. The glyoxal derivatives also have antiviral properties (7, 16) and may be in the center of a hitherto unknown system of equilibria which deserves a thorough study. The low molecular weight of the glyoxal derivative reported justifies the hope of an early clarification of its structure, as well as its synthesis (17).
Determination of the Absolute Thickness of Ultrathin Al<sub>2</sub>O<sub>3</sub> Overlayers on Si (100) Substrate (2009)

The thickness of nanometer Al(2)O(3) films was studied by X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The thickness was determined from mutual calibration of the XPS and TEM measurements. The thickness offset of Al(2)O(3) films was proved to be close to zero by in situ XPS analysis. The thicknesses of a series of Al(2)O(3)/Si (100) films with different Al(2)O(3) thicknesses could be determined by mutual calibration from the thicknesses measured by TEM and XPS. The electron attenuation length of the Al 2p electron was determined as 2.4334 nm in the Al(2)O(3) matrix.
Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells (2003)

Sp7 expression in humans is largely confined to osteoblasts and chondrocytes, both of which differentiate from the mesenchymal lineage. Of the two protein isoforms, the short isoform is most abundant.
Evaluation of the antimicrobial activity of ebselen: Role of the yeast plasma membrane H<sup>+</sup>‐ATPase (2007)

Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is a selenium-containing antioxidant demonstrating anti-inflammatory and cytoprotective properties in mammalian cells and cytotoxicity in lower organisms. The mechanism underlying the antimicrobial activity of ebselen remains unclear. It has recently been proposed that, in lower organisms like yeast, the plasma membrane H+-ATPase (Pma1p) could serve as a potential target for this synthetic organoselenium compound. Using yeast and bacteria, the present study found ebselen to inhibit microbial growth in a concentration- and time-dependent manner, and yeast and Gram-positive bacteria to be more sensitive to this action (IC50 approximately 2-5 microM) than Gram-negative bacteria (IC50 < 80 microM). Washout experiments and scanning electron microscopic analysis revealed ebselen to possess fungicidal activity. In addition, ebselen was found to inhibit medium acidification by PMA1-proficient haploid yeast in a concentration-dependent manner. Additional studies comparing PMA1 (+/-) and PMA1 (+/+) diploid yeast cells revealed the mutant to be more sensitive to treatment with ebselen than the wild type. Ebselen also inhibited the ATPase activity of Pma1p from S. cerevisiae in a concentration-dependent manner. The interaction of ebselen with the sulfhydryl-containing compounds L-cysteine and reduced glutathione resulted in the complete and partial prevention, respectively, of the inhibition of Pma1p ATPase activity by ebselen. Taken together, these results suggest that the fungicidal action of ebselen is due, at least in part, to interference with both the proton-translocating function and the ATPase activity of the plasma membrane H+-ATPase.
Survey of Carcass Characteristics and the Estimated Economic Implications of Carcass Defects (2002)

A quarterly carcass survey was conducted to identify baseline characteristics of the Texas Panhandle cattle population. Carcass data means (±SD) were as follows: USDA yield grade, 2.65 (±0.86); adjusted fat thickness, 1.19 cm (±0.19 cm); hot carcass weight, 337.5 kg (±91.1 kg); longissimus area, 86.0 cm2(±12.3cm2); percent kidney-pelvic-heart fat, 2.09 (±0.45); USDA marbling score, 39.2 (±7.9); and USDA quality grade, High Select. Percentage of carcasses grading low Choice or greater increased as yield grade increased. A large proportion of carcasses surveyed were USDA Select, Yield Grade 2. Heifers had more desirable yield and quality grades than steers. Although no trends were evident, significant differences in USDA yield grade, fat thickness, hot carcass weight, longissimus area, and kidney-pelvic-heart fat were observed among the four collection periods; however, no difference was found for marbling score. Because of excessive Yield Grade 4, low quality grade, lightweight, carcass defects [dark, firm, and dry (DFD)], and excessive maturity discounts likely from an increased population of heifer carcasses, the frequency of carcass defects was almost twice as great in February as in May. Incidence and estimated economic impact per carcass associated with defects were as follows: USDA yield grade ≥ 4.0, 6.37%, $7.48; low USDA quality (quality grade ≤ High Standard) 5.34%, $8.62; outlying carcass weight (<250 kg or >430kg) 3.01%, $4.09; excessive external fat (≥0.635 cm trim), $69.12 (steers) and $61.26 (heifers); DFD, 1.31%, $2.69; other carcass defects, 0.69%, $1.59. Estimated decreased carcass values based on defects were $92.00 per steer and $84.14 per heifer.
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β (2001)

The proinflammatory cytokine IL-18 was investigated for its role in human myocardial function. An ischemia/reperfusion (I/R) model of suprafused human atrial myocardium was used to assess myocardial contractile force. Addition of IL-18 binding protein (IL-18BP), the constitutive inhibitor of IL-18 activity, to the perifusate during and after I/R resulted in improved contractile function after I/R from 35% of control to 76% with IL-18BP. IL-18BP treatment also preserved intracellular tissue creatine kinase levels (by 420%). Steady-state mRNA levels for IL-18 were elevated after I/R, and the concentration of IL-18 in myocardial homogenates was increased (control, 5.8 pg/mg vs. I/R, 26 pg/mg; P < 0.01). Active IL-18 requires cleavage of its precursor form by the IL-1β-converting enzyme (caspase 1); inhibition of caspase 1 also attenuated the depression in contractile force after I/R (from 35% of control to 75.8% in treated atrial muscle; P < 0.01). Because caspase 1 also cleaves the precursor IL-1β, IL-1 receptor blockade was accomplished by using the IL-1 receptor antagonist. IL-1 receptor antagonist added to the perifusate also resulted in a reduction of ischemia-induced contractile dysfunction. These studies demonstrate that endogenous IL-18 and IL-1β play a significant role in I/R-induced human myocardial injury and that inhibition of caspase 1 reduces the processing of endogenous precursors of IL-18 and IL-1β and thereby prevents ischemia-induced myocardial dysfunction.
Specific assays for bacteria using phage mediated release of adenylate kinase (1998)

A sensitive and rapid assay method for the specific detection of bacteria was developed using Escherichia coli and Salmonella newport as the test organisms. Bacteriophages were used to provide specific lysis of the bacteria and then the release of cell contents was measured by ATP bioluminescence. Increased sensitivity was obtained by focusing on the bacteria's adenylate kinase (AK) as the cell marker instead of ATP as conventionally used. Fewer than 10(3) E. coli cells could be readily detected in less than 1 h. Salmonella newport assays, although as sensitive, were slower and took up to 2 h. The effects of the culture medium, the phage, and the presence of non-specific bacteria were examined.
Synthesis and Biological Activities of (<i>R</i>)- and (<i>S</i>)-<i>N</i>-(4-Methoxyphenyl)-<i>N</i>,2,6-trimethyl-6,7-dihydro-5<i>H</i>-cyclopenta[<i>d</i>]pyrimidin-4-aminium Chloride as Potent Cytotoxic Antitubulin Agents (2011)

(R,S)-1 is a potent antimitotic compound. (R)-1·HCl and (S)-1·HCl were synthesized from (R)- and (S)-3-methyladipic acid. Both enantiomers were potent inhibitors of cell proliferation and caused cellular microtubule loss and mitotic arrest. They inhibited purified tubulin assembly and the binding of [(3)H]colchicine to tubulin, with (S)-1 being about twice as potent. Cytotoxicity against 60 tumor cell lines, however, indicated that the (S)-isomer was 10- to 88-fold more potent than the (R)-isomer.
Absorption Losses of Low Loss Plastic Optical Fibers (1985)

Absorption loss factors such as the high harmonics of molecular vibrational absorption and the electronic transitional absorption of plastic optical fibers are analyzed and it is quantitatively revealed that the high harmonics of the CH vibrational absorption of core material are the most significant constituents causing the loss in PMMA-core fibers. OH vibrational absorption due to contained water, on the other hand, has the most effect on loss in perdeuterated PMMA (P(MMA-d8)) core fibers. Visible wavelengths (570 and 650 nm) are preferable for optical signal transmission for PMMA- or P(MMA-d8)-core fibers.
Teredinibacter turnerae gen. nov., sp. nov., a dinitrogen-fixing, cellulolytic, endosymbiotic gamma-proteobacterium isolated from the gills of wood-boring molluscs (Bivalvia: Teredinidae). (2002)

A cellulolytic, dinitrogen-fixing bacterium isolated from the gill tissue of a wood-boring mollusc (shipworm) Lyrodus pedicellatus of the bivalve family Teredinidae and 58 additional strains with similar properties, isolated from gills of 24 bivalve species representing 9 of 14 genera of Teredinidae, are described. The cells are Gram-negative, rigid, rods (0.4-0.6 x 3-6 microm) that bear a single polar flagellum. All isolates are capable of chemoheterotrophic growth in a simple mineral medium supplemented with cellulose as a sole source of carbon and energy. Xylan, pectin, carboxymethylcellulose, cellobiose and a variety of sugars and organic acids also support growth. Growth requires addition of combined nitrogen when cultures are vigorously aerated, but all isolates fix dinitrogen under microaerobic conditions. The pH, temperature and salinity optima for growth were determined for six isolates and are approximately 8.5, 30-35 degrees C and 0.3 M NaCl respectively. The isolates are marine. In addition to NaCl, growth requires elevated concentrations of Ca2+ and Mg2+ that reflect the chemistry of seawater. The DNA G+C content ranged from 49 to 51 mol%. Four isolates were identical with respect to small-subunit rRNA sequence over 891 positions compared and fall within a unique clade in the gamma-subclass of the Proteobacteria. Based on morphological, physiological and phylogenetic characteristics and specific symbiotic association with teredinid bivalves, a new genus and species, Teredinibacter turnerae gen. nov., sp. nov., is proposed. The type strain is T7902(T) (= ATCC 39867(T) = DSM 15152(T)).
Formation of battery plates. [20 to 100 times the usual formation current] (1975)

Plates for batteries are formed by applying formation current and intermittently depolarizing the plates and electrolyte at either preselected intervals or in response to one or more monitored characteristics of the plates and electrolyte. Plates for lead-acid batteries are formed while immersed in either a dilute solution of sulfuric acid or the solution to be used as the electrolyte in the battery. The formation current for plates for lead--acid batteries is in excess of 20 times the usual formation current, and may be more than 100 times the usual formation current. 5 figures (auth)
Thermography-based blood flow imaging in human skin of the hands and feet: a spectral filtering approach (2017)

The determination of the relationship between skin blood flow and skin temperature dynamics is the main problem in thermography-based blood flow imaging. Oscillations in skin blood flow are the source of thermal waves propagating from micro-vessels toward the skin's surface, as assumed in this study. This hypothesis allows us to use equations for the attenuation and dispersion of thermal waves for converting the temperature signal into the blood flow signal, and vice versa. We developed a spectral filtering approach (SFA), which is a new technique for thermography-based blood flow imaging. In contrast to other processing techniques, the SFA implies calculations in the spectral domain rather than in the time domain. Therefore, it eliminates the need to solve differential equations. The developed technique was verified within 0.005-0.1 Hz, including the endothelial, neurogenic and myogenic frequency bands of blood flow oscillations. The algorithm for an inverse conversion of the blood flow signal into the skin temperature signal is addressed. The examples of blood flow imaging of hands during cuff occlusion and feet during heating of the back are illustrated. The processing of infrared (IR) thermograms using the SFA allowed us to restore the blood flow signals and achieve correlations of about 0.8 with a waveform of a photoplethysmographic signal. The prospective applications of the thermography-based blood flow imaging technique include non-contact monitoring of the blood supply during engraftment of skin flaps and burns healing, as well the use of contact temperature sensors to monitor low-frequency oscillations of peripheral blood flow.
Axiomatization of dynamic schema evolution in object bases (2002)

The schema of a system consists of the constructs that model its entities. Schema evolution is the timely change and management of the schema. Dynamic schema evolution is the management of schema changes while the system is in operation. We propose a sound and complete axiomatic model for dynamic schema evolution in object-base management systems (OBMSs) that support subtyping and property inheritance. The model is formal, which distinguishes it from the traditional approach of informally defining a number of invariants and rules to enforce them. By reducing systems to the axiomatic model, their functionality with respect to dynamic schema evolution can be compared within a common framework.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Antitumor Activity of Ionic Liquids Based on Ampicillin (2015)

Significant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic ampicillin with appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient ionic liquids (API-ILs) that show potent antiproliferative activities against five different human cancer cell lines: T47D (breast), PC3 (prostate), HepG2 (liver), MG63 (osteosarcoma), and RKO (colon). Some API-ILs showed IC50 values between 5 and 42 nM, activities that stand in dramatic contrast to the negligible cytotoxic activity level shown by the ampicillin sodium salt. Moreover, very low cytotoxicity against two primary cell lines-skin (SF) and gingival fibroblasts (GF)-indicates that the majority of these API-ILs are nontoxic to normal human cell lines. The most promising combination of antitumor activity and low toxicity toward healthy cells was observed for the 1-hydroxyethyl-3-methylimidazolium-ampicillin pair ([C2 OHMIM][Amp]), making this the most suitable lead API-IL for future studies.
The social structure of free and open source software development (2005)

Metaphors, such as the Cathedral and Bazaar, used to describe the organization of FLOSS projects typically place them in sharp contrast to proprietary development by emphasizing FLOSS’s distinctive social and communications structures. But what do we really know about the communication patterns of FLOSS projects? How generalizable are the projects that have been studied? Is there consistency across FLOSS projects? Questioning the assumption of distinctiveness is important because practitioner–advocates from within the FLOSS community rely on features of social structure to describe and account for some of the advantages of FLOSS production. To address this question, we examined 120 project teams from SourceForge, representing a wide range of FLOSS project types, for their communications centralization as revealed in the interactions in the bug tracking system. We found that FLOSS development teams vary widely in their communications centralization, from projects completely centered on one developer to projects that are highly decentralized and exhibit a distributed pattern of conversation between developers and active users. We suggest, therefore, that it is wrong to assume that FLOSS projects are distinguished by a particular social structure merely because they are FLOSS. Our findings suggest that FLOSS projects might have to work hard to achieve the expected development advantages which have been assumed to flow from "going open." In addition, the variation in communications structure across projects means that communications centralization is useful for comparisons between FLOSS teams. We found that larger FLOSS teams tend to have more decentralized communication patterns, a finding that suggests interesting avenues for further research examining, for example, the relationship between communications structure and code modularity.
Gender difference in letrozole pharmacokinetics in rats. (2000)

There are marked gender differences in Letr pharmacokinetics in rats.
All optical fibre auxiliary carrier based 2R regenerator (2005)

A novel all-optical 2R regenerator is proposed. Reshaping and conversion behaviours in a multi-wave- mixing regime inside a particular dispersion-shifted fibre are induced on a third auxiliary carrier improving the conversion range and bit-error-rate performances.
Self-Folding Origami Microstrip Antennas (2014)

This communication presents antennas that incorporate self-folding polymer substrates that transform planar, two-dimensional structures into three-dimensional antennas when exposed to a light source. Pre-strained polystyrene sheets supporting a patterned copper foil form the light-activated structures. Black ink that is inkjet printed on the polymer substrate selectively absorbs light and controls the shape of the transformation. This approach represents a simple method to reconfigure the shape of an antenna and a hands-free method to assemble 3D antennas from many of the conventional methods that are used to pattern 2D metal foils. We demonstrate and characterize two embodiments that highlight this concept: a monopole antenna that transforms from a conventional microstrip transmission line and a microstrip patch antenna that converts within seconds into a monopole antenna.
An accurate CMOS sample-and-hold circuit (1992)

An accurate sample-and-hold (S/H) circuit implemented with a 2- mu m double-poly CMOS process is described. Competitive performance in terms of output swing, linearity, and clock feedthrough compensation was obtained using a new circuit topology. The sample and hold operates up to 1 MHz of sampling frequency with less than -60 dB of total harmonic distortion. The accuracy of the held step is better than 0.2 mV. The circuit dissipates 4 mW with a 5-V power supply.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mitochondrial dysfunction and chronic disease: treatment with natural supplements. (2014)

Loss of function in mitochondria, the key organelle responsible for cellular energy production, can result in the excess fatigue and other symptoms that are common complaints in almost every chronic disease. At the molecular level, a reduction in mitochondrial function occurs as a result of the following changes: (1) a loss of maintenance of the electrical and chemical transmembrane potential of the inner mitochondrial membrane, (2) alterations in the function of the electron transport chain, or (3) a reduction in the transport of critical metabolites into mitochondria. In turn, these changes result in a reduced efficiency of oxidative phosphorylation and a reduction in production of adenosine-5'-triphosphate (ATP). Several components of this system require routine replacement, and this need can be facilitated with natural supplements. Clinical trials have shown the utility of using oral replacement supplements, such as L-carnitine, alpha-lipoic acid (α-lipoic acid [1,2-dithiolane-3-pentanoic acid]), coenzyme Q10 (CoQ10 [ubiquinone]), reduced nicotinamide adenine dinucleotide (NADH), membrane phospholipids, and other supplements. Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue.
Superoxide dismutase mimics and other redox‐active therapeutics (2016)

Cellular metabolism is largely redox based, that is, involves shutting of electrons among biomolecules. The most crucial enzymes of the first-line defense against oxidative stress in all living organisms are members of the family of superoxide dismutases SODs When designing SOD mimics, the thermodynamic (the ability to accept and give electron to superoxide) and kinetic properties (the rate of electron transfer) of SOD enzyme were mimicked. In addition, the high stability of such molecules with regard to the loss of redox-active metal center was sought. Apart from SOD mimics, different other redox-active compounds have been developed and exhibit therapeutic effects in cellular and animal models of diseases. Several studies provided evidence that Mn porphyrins are able to suppress cellular transcription. Impact on signaling proteins may be one the major mechanisms of MnP actions.
SP 800-38D. Recommendation for Block Cipher Modes of Operation: Galois/Counter Mode (GCM) and GMAC (2007)

This Recommendation specifies the Galois/Counter Mode (GCM), an algorithm for authenticated encryption with associated data, and its specialization, GMAC, for generating a message authentication code (MAC) on data that is not encrypted. GCM and GMAC are modes of operation for an underlying approved symmetric key block cipher.
Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands. (1978)

Urogastrone has been localised by immunostaining to granules of the cells of human duodenal (Brunner's) glands and their ducts and of acinar cells in the human submandibular gland. The immunoreactive peptide is present in large quantities in duodenal glands and their secretory ducts. Urogastrone or human epidermal growth factor promotes cellular proliferation in vivo as well as in vitro and inhibits gastric acid secretion and may, therefore, be one of the duodenal factors inhibiting gastric activity. Thus it may have an important regulatory and protective function for the intestinal mucosa and may possibly become a useful therapeutic agent.