gebhart/patrepeval huggingface dataset:
Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE−/− Mice (2008)

Objective— In this article, we studied the effect of acetyl-11-keto-β-boswellic acid (AKβBA), a natural inhibitor of the proinflammatory transcription factor NF-κB on the development of atherosclerotic lesions in apolipoprotein E–deficient (apoE−/−) mice. Methods and Results— Atherosclerotic lesions were induced by weekly LPS injection in apoE−/− mice. LPS alone increased atherosclerotic lesion size by ≈100%, and treatment with AKβBA significantly reduced it by ≈50%. Moreover, the activity of NF-κB was also reduced in the atherosclerotic plaques of LPS-injected apoE−/− mice treated with AKβBA. As a consequence, AKβBA treatment led to a significant downregulation of several NF-κB–dependent genes such as MCP-1, MCP-3, IL-1α, MIP-2, VEGF, and TF. By contrast, AKβBA did not affect the plasma concentrations of triglycerides, total cholesterol, antioxidized LDL antibodies, and various subsets of lymphocyte-derived cytokines. Moreover, AKβBA potently inhibited the IκB kinase (IKK) activity immunoprecipitated fro...
Determination of failure rates of underground distribution system components from historical data (2002)

It is shown how failure rates of underground distribution system components can be determined from historical data. When these data are complete, the time dependence of the failure rates can be found. A complete set of data contains a record beginning with the first installation of the component type and including the number of components mailed (or removed) and the number which failed during each year of the record. The method is applied in the determination of failure rates for high molecular weight polyethylene (HMPE) 15 kV unjacketed cable, cross-linked polyethylene (XLPE) 15 kV unjacketed cable, single phase distribution transformers, and load break elbows. Data for these components were made available by San Diego Gas and Electric Company and the Northwest Electric Light and Power Association. A record spanning some 20 years of data was used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Research and design of the PMI-based access control model for OpenVPN (2010)

Open VPN is commonly used to remotely access a variety of resources in the enterprise networks. However, there is a deficiency that Open VPN can only provide coarse-grained access control. It brings in security problems in accessing the key resources with different security levels. To solve this problem, this paper analysis the security technology and the traditional access control of OpenVPN, and proposed a novel fine-grained access control model which is based on the Privilege Management Infrastructure (PMI). This model extended the handshake procedure of OpenVPN by adding the authentication of Attribute Certificate. The authentication of Attribute Certificate which we added is optional. Our access control model is efficient by completing the authentication and authorization at the same time.
Gas separation modes in a hollow fiber contained liquid membrane permeator (1992)

The feasibility of gas purification using the hollow fiber contained liquid membrane (HFCLM) technique under four different operational modes, such as sweep gas, sweep liquid, conventional permeation, and vacuum, has been investigated. Separations of binary gas mixtures containing CO 2 and N 2 or CO 2 and CH 4 have been studied with special emphasis on model biogas mixture. Separation and purification through a nonreactive liquid membrane, e.g., water, and a reactive liquid membrane, such as an aqueous solution of diethanolamine (DEA), were investigated. Permeation models were proposed for all modes
Further Evidence for a Dissociation Between Different Forms of Mnemonic Expressions in a Mouse Model of Age-related Cognitive Decline: Effects of Tacrine and S 17092, a Novel Prolyl Endopeptidase Inhibitor (2000)

It has been demonstrated previously on the radial maze that the emergence of an age-related mnemonic impairment is critically dependent on the form which the discrimination problems took. Hence, when the arms were presented one by one (i.e., successive go-no-go discrimination), both adult and aged mice learned to distinguish between positive (baited) and negative (unbaited) arms readily, as evidenced by their increased readiness to enter positive relative to negative arms (i.e., by a differential in arm-entry latencies). A selective impairment in the aged mice was seen when these arms were presented subsequently as pairs, such that the mice were confronted with an explicit choice (i.e., simultaneous 2-choice discrimination). When discriminative performance was measured by the differential run speed between positive and negative arms, aged mice were also impaired. This was particularly pronounced in the 2-choice discrimination condition. We examined the effects of tacrine (3mg/kg, subcutaneously) or S 17092 (10mg/kg, orally) in aged mice on the three behavioral indices of this 2-stage spatial discrimination paradigm. The results indicated that: (1) Tacrine, but not S 17092, enhanced the acquisition of go-no-go discrimination as reflected in arm-entry latencies; (2) both drugs improved choice accuracy in simultaneous discrimination, although the effect of tacrine was less striking and, in particular, far from statistical significance in the very first 2-choice responses; and (3) neither drugs significantly affected run-speed performance. We conclude further that the specific patterns of drug effects on the three indices of discriminative performance might suggest that each index is associated with a distinct form of mnemonic expression relying on separate neural systems.
Solution structure and dynamics of mouse ARMET (2010)

ARMET is an endoplasmic reticulum (ER) stress-inducible protein that is required for maintaining cell viability under ER stress conditions. However, the exact molecular mechanisms by which ARMET protects cells are unknown. Here, we have analyzed the solution structure of ARMET. ARMET has an entirely alpha-helical structure, which is composed of two distinct domains. Positive charges are dispersed on the surfaces of both domains and across a linker structure. Trypsin digestion and (15)N relaxation experiments indicate that the tumbling of the N-terminal and C-terminal domains is effectively independent. These results suggest that ARMET may hold a negatively charged molecule using the two positively charged domains.
노인의 주관적 구강건강상태가 대인관계에 미치는 영향 (2011)

The study of the elderly and poor oral status interpersonal relationships and smooth social life limited to give is the social alienation and isolation, promoting to having problems with a sense of the elderly subjective oral health status and Subjective oral health status of the elderly Effects of interpersonal relations affects whether analyzed. 1.Subjective oral health status authoring feel healthy food disorders, toothache, gum disease, temporomandibular disorders, dry mouth, bad breath and other symptoms ‘sometimes’‘often’ than the ‘no’ appears to be highly subjective interpersonal Oral health status affects interpersonal relationships were a lot. (p <0.01) 2. Subjective oral health status of the seven kinds of sub-variables oral health status, food author disorders, toothache, gum disease, temporomandibular disorders, dry mouth, bad breath, presence and look at the relationship between interpersonal oral health status (r =.349), Toothache (r =.194) than positive (+) was correlated.
Cell Biological Study on Abnormal Proteoglycan Synthesis in Vascular Cells Exposed to Heavy Metals (2004)

Lead and cadmium are toxic heavy metals that have been shown to be possible risk factors of atherosclerosis in epidemiological and experimental studies. Since excess extracellular matrix, including proteoglycans, accumulates changing the composition and the structure in the atherosclerotic vascular wall, the effects of lead and cadmium on the proteoglycan synthesis in vascular cells have been studied using a cell culture system. The following results were obtained: Lead does not destroy endothelial cell layers but markedly inhibits the repair of the injured cell layers, which results from a lower response to endogenous basic fibroblast growth factor caused by inhibition of the synthesis of perlecan, a large heparan sulfate proteoglycan, in vascular endothelial cells. Lead selectively inhibits the synthesis of versican, a large chondroitin sulfate proteoglycan, in vascular smooth muscle cells only at a high cell density. Cadmium induces the synthesis of biglycan and decorin, small dermatan sulfate proteoglycans, in vascular smooth muscle cells only at a low cell density, while inhibiting the synthesis of other proteoglycan molecules. It is therefore suggested that lead and cadmium may influence the developmental process of atherosclerosis through disrupting the regulation of proteoglycan synthesis in vascular cells.
Two different genes encode fibronectin binding proteins in <i>Staphylococcus aureus</i> (1991)

A gene encoding a fibronectin binding protein (FnBP) has recently been isolated and sequenced from Staphylococcus aureus strain 8325-4. In the same bacterial strain, 682 bp downstream to the stop codon of this gene (fnbA), a second gene termed fnbB has not been discovered, encoding another FnBP (FnBPB). The two genes show in large parts striking sequence homologies. The complete amino acid sequence encoded by fnbB has been deduced and compared to that deduced from fnbA. In FnBPB a stretch of 66 amino acids downstream to the signal peptide has 75% identity with the corresponding region in FnBPA. At the C-terminal site another 394 amino acid stretch is almost identical in both gene products. This stretch contains the 38 amino acid long D repeats, the wall spanning Wr repeats and the hydrophobic membrane spanning domain. In FnBPA each of the three D repeats has been identified as a fibronectin binding structure. These structures are highly conserved in FnBPB and most likely represent the major Fn-binding domain of this protein. However, a subclone of gene fnbB lacking the coding region for the D repeats also clearly expresses fibronectin binding activity. This additional binding site is so far unique for FnBPB and interacts like the D domains with the N-terminal 24-31-kDa fragment of fibronectin. The purified recombinant FnBP fragment (not containing the D repeats) completely inhibits the binding of fibronectin to whole cells of S. aureus.
Control of Radiative Exciton Recombination by Charge Transfer Induced Surface Dipoles in MoS2 and WS2 Monolayers (2016)

Due to the two dimensional confinement of electrons in a monolayer of 2D materials, the properties of monolayer can be controlled by electrical field formed on the monolayer surface. F4TCNQ was evaporated on MoS2 and WS2 monolayer forming dipoles between strong acceptor, F4TCNQ, and monolayers of MoS2 or WS2. The strong acceptor attracts electrons (charge transfer) and decreases the number of the ionized excitons. Free excitons undergo radiative recombination in both MoS2 and WS2. Moreover, the photoluminescence enhancement is stronger in WS2 where the exciton-phonon coupling is weaker. The theoretical model indicates that the surface dipole controls the radiative exciton recombination and enhances photoluminescence radiation. Deposition of F4TCNQ on the 2D monolayers enables a convenient control of the radiative exciton recombination and leads to the applications of these materials in lasers or LEDs.
Radical polymerization behavior of 1,1-disubstituted 2-vinylcyclopropanes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical polymerization behavior of 1,1-disubstituted 2-vinylcyclopropanesFumio Sanda, Toshikazu Takata, and Takeshi EndoCite this: Macromolecules 1993, 26, 8, 1818–1824Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://doi.org/10.1021/ma00060a004Request reuse permissionsArticle Views355Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (653 KB) Get e-Alertsclose Get e-Alerts
A Study on Activation of Citizen Guardians in Aging Society (2013)

The adult guardianship system takes effect from July 2013, to protect adults who need protection due to insufficient ability to judge, and help them lead a normal life. It is very important to identify the problems and solutions of the country's through the analysis of Japan that already performs the adult guardianship system, through which there is a need to prepare basis to accomplish the optimal system in advance. It is essential to secure the quality guardians above all, for the successful settlement of the adult guardianship system; the importance of citizen guardians is ever increasing as especially the 'socialization' of the adult guardianship system is supported recently. Therefore, in this study, the trends in the types of the guardians were examined by analyzing the adult guardianship incidents of the Supreme Court of Japan; and the ways to activate the system focused on the citizen guardians.
Image haze removal using a hybrid of fuzzy inference system and weighted estimation (2015)

The attenuation of the light transmitted through air can reduce image quality when taking a photograph outdoors, especially in a hazy environment. Hazy images often lack sufficient information for image recognition systems to operate effectively. In order to solve the aforementioned problems, this study proposes a hybrid method combining fuzzy theory with weighted estimation for the removal of haze from images. A transmission map is first created based on fuzzy theory. According to the transmission map, the proposed method automatically finds the possible atmospheric lights and refines the atmospheric lights by mixing these candidates. Weighted estimation is then employed to generate a refined transmission map, which removes the halo artifact from around the sharp edges. Experimental results demonstrate the superiority of the proposed method over existing methods with regard to contrast, color depth, and the elimination of halo artifacts.
Introduction: The Mexican Political System (1992)

The laws of thermodynamics are said to predict that the bumble bee cannot fly. There are no equivalent laws governing political systems but the continued survival of the Mexican system still surprises. Every few years a scholarly analysis will declare that Mexican politics is in crisis;1 a former student of mine, apparently without irony, once wrote that ‘the most consistent feature of Mexican politics is the crisis’. Yet the Mexican system, unusually for Latin America, has produced two generations of political stability; for most Mexicans, these years have not been especially unhappy. So why is a system which is apparently capable of working quite well so regularly denounced as fundamentally unviable?
Crosslinked Hemoglobin-Superoxide Dismutase-Catalase Scavenges Free Radicals in a Rat Model of Intestinal Ischemia-Reperfusion Injury (1997)

An in vivo rat model of isolated intestinal ischemia-perfusion was developed.This is used to compare the effects of crosslinked hemoglobin (PolyHb) versus crosslinked hemolobin-superoxide dismutase-catalase (PolyHb-SOD-CAT) on free radical generation in ischemia-reperfusion. Fasted, anesthetized male Sprague Dawley rats underwent midline laparotomy with cannulation of the abdominal aorta and inferior vena cava.Ligation was carried out at the renal pedicles bilaterally and the aorta and vena cava proximally at the diaphragm and distally above the femoral bifurcation.The system was flushed of blood with 20 ml of lactated Ringer's solution.The portal vein was then cannulated with distal clamping at the porta hepatis so that isolated intestinal perfusion could be achieved with the aorta as the inlet and the portal vein as the outlet.Following a 90 minute ischemic time, perfusates containing modified hemoglobin (5 g/dl) and 4-hydroxybenzoate (5 mM) were infused at 0.8 mumin for 10 min.Portal vein eMuent samples were collected at 2.5 minute intervals.Hydroxyl radical generation was assessed by an aromatic hydroxylation technique with 4hydroxybenzoate (4HB).Reaction of hydroxyl radical with 4HB produces 3,4 dihydroxybenzoate (3,4 DHBA).In the PolyHb group, the levels of 3,4-DHBA 181 Copyright 0 1997 by Marcel Dekker.Inc. increased 10.75-13.58x-fold above pre-perfusion values compared to 2.25-3.75xfold in PolyHb-SOD-CAT group.This indicates that PolyHb-SOD-CAT is effective in reducing in vivo hydroxyl radical generation following reperfusion.Since free radicals may play a major role in the pathogenesis of ischemia-reperfusion injury, this suggests a role for PolyHb-SOD-CAT as a possible protective perfusate in intestinal reperfusion injury.
Raman and Infrared Spectra of Rhombohedral Selenium (1981)

Raman and infrared spectra of rhombohedral selenium have been measured and the fundamental bands observed in these spectra are assigned by analogy to the S 6 ring molecule. Calculation of the normal mode vibration for the Se 6 ring using a modified Urey-Bradley force field confirms this assignment. Anomalous softening of the A 1g stretching mode relative to other modes and to the corresponding A 1 mode in the Se 8 ring was observed. This phenomenon is explained by the idea of interference of inter-molecular interaction with the intra-molecular bonding. Comparison of the observed spectra of rhombohedral selenium with those of other allotropes (α-monoclinic, trigonal, and amorphous selenium) suggests that Se 6 ring molecules may exist in amorphous selenium.
Pharmacodynamic (PD) Biomarker Assay Validation for SB1518, a Novel Oral JAK2 Inhibitor in Phase 1 Clinical Trials for Advanced Leukemias, Myeloproliferative Diseases and Lymphoma. (2009)

Abstract Abstract 1888 Poster Board I-911 Introduction: Abnormalities in JAK2 and FLT3 kinases are reported in various hematological malignancies and may underlie the pathogenesis of these diseases. An activating mutation of JAK2, namely JAK2V617F is the most common mutation in bcr-abl-negative chronic myeloproliferative disorders (MPDs). Activation of wild type JAK2 has been reported in Hodgkin lymphoma (HL) and primary mediastinal large cell Non-Hodgkin lymphomas (NHL) due to loss of Suppressor of Cytokine Signaling (SOCS)-1 gene. Abnormalities in FLT3 are present in ∼30% of acute myelogenous leukemias (AML). SB1518 is a potent inhibitor of both JAK2 (IC50 = 22 nM) and its JAK2V617F mutant (IC50 = 19 nM) as well as FLT3 (IC50 = 22 nM) and it mutant D835Y (IC50 = 6 nM). As a consequence, SB1518 inhibits the proliferation of human leukemia and lymphoma cell lines dependent on either JAK2 or FLT3 activation (IC50 =35–240 nM), and has antitumor activity in nude mouse models of FLT3- (MV4-11) or JAK2-dependent (BaF3-JAK2V617F) leukemia. SB1518 is currently being evaluated in Phase 1 clinical trials for advanced leukemias, MPDs and lymphoma. We describe here the development and assessment of biochemical biomarkers to assess the pharmacodynamic (PD) efficacy of SB1518 in the phase I clinical trials. Methods and Results: Sensitive flow cytometric and quantitative Western-blot assays were developed for measuring downstream JAK2 and FLT-3 signaling; namely STAT5/3 phosphorylation in tumor tissue, fixed cells from whole blood or lysed PBMCs. These assays were validated by demonstrating target inhibition after ex vivo treatment of PBMCs from healthy human donors and in blood cells and tumor tissue after oral dosing of normal and tumor bearing nude mice with SB1518. Initial data obtained from analysis of whole blood and PBMCs from patients treated with SB1518 in the ongoing Phase 1 clinical trials demonstrate target inhibition even at the lowest dose level of 100 mg/day on the first day of oral dosing. Conclusion: In summary, we have developed and quantitative biomarker assays and applied them to demonstrate PD target efficacy of SB1518 in animal tumor models as well as patients in ongoing phase 1 clinical trials. Disclosures: Hart: S*BIO PTE LTD: Employment, Equity Ownership. Goh:S*BIO PTE LTD: Employment. Tan:S*BIO PTE LTD: Employment. Chithra:S*BIO PTE LTD: Employment. Wood:S*BIO PTE LTD: Employment.
Comparison of effects of suture and cyanoacrylate tissue adhesive on bacterial counts in contaminated lacerations (1995)

We studied the effects of closing lacerations with suture or cyanoacrylate tissue adhesive on staphylococcal counts in inoculated guinea pig lacerations. Wounds closed with adhesive alone had lower counts than wounds containing suture material (P < 0.05). The results of a time-kill study were consistent with a bacteriostatic adhesive effect of the adhesive against Staphylococcus aureus.
Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation (2010)

Our data suggests persistent cellular changes of anti-oxidative machinery and of aerobic/anaerobic glycolysis are present in T1D and T1D+ESRD patients, and these abnormalities may play a key role in the pathogenesis of hyperglycemia-related vascular complications. Restoration of normoglycemia and removal of uremia with KP transplant can correct these abnormalities. Some of these identified pathways may become potential therapeutic targets for a new generation of drugs.
Digital transmission with coherent four-dimensional modulation (1974)

This paper examines codes for four-dimensional (4-D) modulation and their performance for digital transmission. The signals are defined by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> points inside a sphere in four-dimensional Euclidian space. Three classes of 4-D codes are presented, and an algorithm is given which yields good 4-D codes of any length. Bounds on symbol error probability are plotted versus symbol-energy-to-noise-density ratio. The performance is shown to exceed that of amplitude- and-phase modulation in two independent two-dimensional channels.
Neurotoxin tetrodotoxin as attractant for toxic snails (2004)

The attracting effect of a small dose of tetrodotoxin (TTX) on eight toxic snail species (Polinices didyma, Natica lineata, Natica vitellus, Zeuxis sufflatus, Niotha clathrata, Oliva miniacea, Oliva mustelina and Oliva hirasei) and two non-toxic species (Pomacea canaliculata and Satsuma bairdi) was investigated. Each toxic snail species was determined to contain TTX. The minimum lethal dose of TTX for most toxic snails was estimated to be >44.5 μg TTX/20 g body weight, but for non-toxic snails it was <3.6 μg TTX/20 g body weight. After the attracting test, it was found that for all toxic snails there was a significantly positive relationship between the comparative attracting variation and the toxicity reported, and this relationship was linear (y=5.895x+3.443, r=0.806). The relationship between TTX resistance ability and toxicity also had a positive correlation (y=0.113x+52.447, r=0.814). However, non-toxic species showed a negative response. The more toxic snails appeared to prefer TTX, indicating that TTX is an attractant for toxic snails.