gebhart/patrepeval huggingface dataset:
Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism (1992)

Transcription from the human immunodeficiency virus type 1 (HIV-1) provirus is activated by a cellular factor, NF kappa B, recognizing the tandemly repeated 10-base-pair sequences, termed the kappa B sequence, present in the enhancer region within the viral long terminal repeat (LTR). Using electrophoretic mobility shift assay (EMSA), which demonstrates specific DNA-protein interaction in vitro, we could demonstrate that reducto-oxidative modulation of NF kappa B dramatically changes its DNA binding activity and that a cellular physiological reducing catalyst, thioredoxin (TRX) also known as adult T cell leukemia derived factor (ADF), fully restored the DNA-binding activity of the oxidized NF kappa B. We also observed that purified TRX/ADF protein could augment gene expression from HIV LTR as demonstrated by transient chloramphenicol acetyltransferase (CAT) assay. These observations confirmed the previous notion that ADF might be an inducing factor of cellular interleukin-2 receptor alpha subunit (IL-2R alpha) through the kappa B sequence that is a common central cis-regulatory element in both IL-2R alpha and HIV gene expression. These observations indicate that reducto-oxidative regulation (or redox regulation) of a cysteine residue(s) on the NF kappa B molecule might play an important role in its specific DNA interaction and that it might provide a clue to the understanding of a pathway of cellular signal transduction to NF kappa B that is independent from the known pathways involving protein phosphorylation.
A novel approach for precise characterization of long distance mismatch of CMOS-devices (2002)

A new test structure is presented for the characterization of long distance mismatch of CMOS devices. A single circuit is used to characterize both transistors and resistors. High resolution is achieved by applying a four-terminal method with regulated reference potential to compensate for parasitic resistance effects. Measured data are presented for different CMOS processes to demonstrate the performance of this approach. In particular, the long distance matching behavior is compared to that of neighboring devices and examples for linear and nonlinear distance dependencies are shown.
Uveal melanoma: epidemiology, etiology, and treatment of primary disease (2017)

Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of patients will develop metastatic disease with 6-12 months' survival from metastatic diagnosis. Genomic analyses have led to the development of gene-expression profiles that effectively predict metastatic progression; unfortunately, no adjuvant therapy has been shown to prolong survival to date. New insights into the molecular biology of UM have found frequent activating mutations in genes encoding for the G-protein α-subunit, <i>GNAQ</i> and <i>GNA11</i>, and improved understanding of the downstream signaling pathways MAPK, PI3K/Akt, and Hippo have afforded an array of new targets for treatment of this disease. Studies are under way with rationally developed regimens targeting these pathways, and novel agents are under development. We review the diagnosis, management, and surveillance of primary UM and the adjuvant therapy trials under way.
Regulation of Arabinose and Xylose Metabolism in<i>Escherichia coli</i> (2009)

Bacteria such as Escherichia coli will often consume one sugar at a time when fed multiple sugars, in a process known as carbon catabolite repression. The classic example involves glucose and lactose, where E. coli will first consume glucose, and only when it has consumed all of the glucose will it begin to consume lactose. In addition to that of lactose, glucose also represses the consumption of many other sugars, including arabinose and xylose. In this work, we characterized a second hierarchy in E. coli, that between arabinose and xylose. We show that, when grown in a mixture of the two pentoses, E. coli will consume arabinose before it consumes xylose. Consistent with a mechanism involving catabolite repression, the expression of the xylose metabolic genes is repressed in the presence of arabinose. We found that this repression is AraC dependent and involves a mechanism where arabinose-bound AraC binds to the xylose promoters and represses gene expression. Collectively, these results demonstrate that sugar utilization in E. coli involves multiple layers of regulation, where cells will consume first glucose, then arabinose, and finally xylose. These results may be pertinent in the metabolic engineering of E. coli strains capable of producing chemical and biofuels from mixtures of hexose and pentose sugars derived from plant biomass.
for Merged Transistor L,ogic (MTL) (1974)

Absfnzc f—The merged transistor device is represented by assigning separate diodes to the various electron and hole injections along the active p-n junctions. Where collection takes place, current sources are introduced. Measurement procedures are described tliat allow a quantitative separation of the various injections, and hence the determination of the model parameters. Results of such measurements are given. Device terminal parameters, like current gains and storage time constants, can be predicted from the measurements for devices of arbitrary horizontal geometry, so that the injection model can serve as a device optimization tool. As a circuit analysis model it allows representation of the internal device series resistances which would not be possible with an Ebers-Moll model. The injection model is significant beyond the merged transistor logic (IvITL) aspects as it renders a better insight into bipolar devices, particularly into lateral p-n-p and saturated n-p-n transistors.
Design of a spiral-mode microstrip antenna and matching circuitry for ultra-wide-band receivers (2003)

The expanding use of wireless devices has prompted the need of larger bandwidths by these devices. This need is a result of larger bit-rates or the use of different standards using different frequency bands. In this work, the design and test of a wide band antenna and its matching circuit is presented The wide band antenna is of the Archimedes type because it has a compact size and can be easily manufactured using inexpensive PCB technology. The possibility of including the matching circuitry in the same PCB is also studied.
New synthesis of 2-amino-4-oxopyrido[3,2-e]-1,3-thiazines and 1-alkyl(aryl)pyrido[3,2-e]-2-thiouracils (1983)

Addition reactions of 2-chloronicotinoyl isothiocyanate with primary and secondary amines and subsequent cyclization of intermediate thioureas represent new synthesis of pyrido[3,2- e ]thiouracil and pyrido[3,2- e ]-thiazine derivatives. 2-Amino-4-oxopyrido[3,2- e ]-1,3-thiazines are formed upon heating the reaction components in ethanol, whereas 1-alkyl(aryl)pyrido[3,2- e ]-2-thiouracils are products of alkali-catalyzed reaction. In reaction with primary amines the corresponding thioureas were isolated as intermediates, whereas secondary amines reacted directly to give the pyridothiazine derivatives. Structure of the synthesized compounds was confirmed by their 13 C NMR and mass spectra; also the IR and 1 H NMR spectra are in accord with the suggested formulae.
3D shape measurement of automotive glass by using a fringe reflection technique (2006)

In automotive and glass making industries, there is a need for accurately measuring the 3D shapes of reflective surfaces to speed up and ensure product development and manufacturing quality by using non-contact techniques. This paper describes a technique for the measurement of non-full-field reflective surfaces of automotive glass by using a fringe reflection technique. Physical properties of the measurement surfaces do not allow us to apply optical geometries used in existing techniques for surface measurement based upon direct fringe pattern illumination. However, this property of surface reflectivity can be used to implement similar ideas from existing techniques in a new improved method. In other words, the reflective surface can be used as a mirror to reflect illuminated fringe patterns onto a screen behind. It has been found that in the case of implementing the reflective fringe technique, the phase-shift distribution depends not only on the height of the object but also on the slope at each measurement point. This requires the solving of differential equations to find the surface slope and height distributions in the x and y directions and development of the additional height reconstruction algorithms. The main focus has been made on developing a mathematical model of the optical sub-system and discussing ways for its practical implementation including calibration procedures. A number of implemented image processing algorithms for system calibration and data analysis are discussed and two experimental results are given for automotive glass surfaces with different shapes and defects. The proposed technique showed the ability to provide accurate non-destructive measurement of 3D shapes of the reflective automotive glass surfaces and can be used as a key element for a glass shape quality control system on-line or in a laboratory environment.
KORELASI FAKTOR SOSIAL EKONOMI RUMAH TANGGA DENGAN TINGKAT PENUNGGAKAN PENGEMBALIAN KREDIT P4K DI KECAMATAN MUARA BANGKAHULU KOTA BENGKULU (2009)

This research is intended to study characteristics of P4K creditors who are delinquent their credit payments, examine factors influencing their late P4K credit payments. From 40 P4K creditors, only 23 creditors are able to accessed for this research and willing to participate. Rank spearman correlation and t-test methods are used to analyze the data gathered from respondents. The research finds that the level of family income and respondent’ perception on rural development are highly correlated to the level of P4K credit payment while number of family, working motivation and respondents perception on P4K program are not.Key words: credit payment, socio-economic factors
Automatic detection of performance deviations in the load testing of large scale systems (2013)

Load testing is one of the means for evaluating the performance of Large Scale Systems (LSS). At the end of a load test, performance analysts must analyze thousands of performance counters from hundreds of machines under test. These performance counters are measures of run-time system properties such as CPU utilization, Disk I/O, memory consumption, and network traffic. Analysts observe counters to find out if the system is meeting its Service Level Agreements (SLAs). In this paper, we present and evaluate one supervised and three unsupervised approaches to help performance analysts to 1) more effectively compare load tests in order to detect performance deviations which may lead to SLA violations, and 2) to provide them with a smaller and manageable set of important performance counters to assist in root-cause analysis of the detected deviations. Our case study is based on load test data obtained from both a large scale industrial system and an open source benchmark application. The case study shows, that our wrapper-based supervised approach, which uses a search-based technique to find the best subset of performance counters and a logistic regression model for deviation prediction, can provide up to 89% reduction in the set of performance counters while detecting performance deviations with few false positives (i.e., 95% average precision). The study also shows that the supervised approach is more stable and effective than the unsupervised approaches but it has more overhead due to its semi-automated training phase.
Study of Data Security Based On Cloud Computing (2012)

This paper analysis the core problem of cloud computing: data secure problem, using the newly development of cryprology: fully homomorphism encrytion(FHE) to protect cloud computing data. Put forward data secure scheme based on the character that FHE can operate encrypted data. This scheme not only protect the data, but also can assure the efficency of the application.
[Study on the genetiey relationship between Chinese and Korean medicinal materials of niuxi with the method of RAPD]. (2002)

Korean self-produced A. japonica is near to A. Sidentata.
The component fatty acids of <i>Penicillium lilacinum</i> fat (1956)

1. Trypanooqma rhode8iense, T. gambien8e, T. brucei, T. evansi, T. equinum and T. equiperdum degrade glucose to a mixture of pyruvic acid and glycerol; glycerol production is favoured by anaerobic conditions. The R.Q. is small, usually less than 0.10.
Is glycine effective against elevated blood pressure? (2005)

The use of glycine to lower high blood pressure could have a significant clinical impact in patients with the metabolic syndrome and with limited resources. On the other hand, more studies are needed to explore the beneficial effect of glycine in other models of hypertension and to investigate possible side-effects of treatment with glycine.
Nutrition and Aging: Changes in the Regulation of Energy Metabolism With Aging (2006)

Changes in energy regulation occur during normal aging and contribute to the common phenomenon of weight and fat losses late in life. This review synthesizes data on aging-related changes in energy intake and energy expenditure and on the regulation of energy intake and expenditure. The ability of older adults to accurately regulate energy intake is impaired, with a number of possible explanations including delayed rate of absorption of macronutrients secondary to reductions in taste and smell acuity and numerous hormonal and metabolic mediators of energy regulation that change with aging. There are also changes in patterns of dietary intake and a reduction in the variety of foods consumed in old age that are thought to further reduce energy intake. Additionally, all components of energy expenditure decrease with aging, in particular energy expenditure for physical activity and basal metabolic rate, and the ability of energy expenditure to increase or decrease to attenuate energy imbalance during overeating or undereating also decreases. Combined, these changes result in an increased susceptibility to energy imbalance (both positive and negative) in old age that is associated with deteriorations in health. Practical interventions for prevention of weight and fat fluctuations in old age are anticipated here based on emerging knowledge of the role of such factors as dietary variety, taste, and palatability in late-life energy regulation.
Improved Intermodulation Rejection in Mixers (1966)

Intermodulation is one of the most pernicious forms of spurious response in superheterodyne receivers. This type of interference cannot be completely eliminated by narrowband filters. Improvements in receiver performance can be made only by improving and making more effective use of the mixing element. Intermodulation results from terms of higher order than two in the v-i power series expansion about the dc operating point of the mixing element. The magnitude of these higher order terms must be reduced in order to improve intermodulation rejection. In the work described in this paper, it has been observed that such a reduction in higher order terms can be obtained by proper design of the mixing element and by a proper choice of dc operating point. More than 80 dB intermodulation rejection was obtained with a single ended hot carrier diode mixer. Best performance is obtained by operating two hot carrier diodes at different operating points in a balanced mixer arrangement. Intermodulation ratios greater than 100 dB have been measured for this operating mode. Optimization of performance for IM rejection has little effect on sensitivity or rejection of other spurious responses. A new mixing element, the space-charge-limited resistor (SCLR), was designed to minimize the higher order terms in the current function. A balanced mixer provided the best performance with these mixing elements also. Intermodulation from +5 dBm inputs can be rejected below the mixer noise level. Early models of this device are not as sensitive as hot carrier mixers, but improvement appears to be possible.
Secretion of gamma-glutamyl hydrolase in vitro. (1991)

gamma-Glutamyl hydrolase (also known as conjugase) is a ubiquitous enzyme that has the capacity to cleave folyl- and antifolylpolyglutamates. This study has revealed that the enzyme is secreted by primary cultures of rat hepatocytes and by H35 hepatoma cells. H35 cells have lower cellular levels of gamma-glutamyl hydrolase than do hepatocytes but secrete a greater proportion of gamma-glutamyl hydrolase. More than 99% of the total enzyme from H35 cells accumulated in the medium after 48 h. The cells were shown to remain intact during the secretion period since lactate dehydrogenase, dihydrofolate reductase, and lysosomal hydrolases other than gamma-glutamyl hydrolase were retained within the cell. Using the substrate 4-amino-10-methyl-pteroyldiglutamate (4-NH2-10-CH3-Pte-Glu2), the intracellular and secreted enzyme form(s) from H35 cells were found to have the following properties (a) Km values of 24.3 +/- 3.7 microM and 34.8 +/- 8.6 microM, respectively, and (b) maximal activity at pH 5 to 7 and apparent molecular weights of 120,000 by gel filtration. Both the cellular and secreted enzymes convert 4-NH2-10-CH3-PteGlu4 and pteroylpentaglutamate acid, to the corresponding monoglutamates with little or no appearance of intermediate chain length polyglutamates. This suggests that both act primarily as endopeptidases. Thus far, the cellular and secreted enzymes cannot be differentiated although the current studies do not establish this point unequivocally. Alterations in the cellular and secreted H35 cell gamma-glutamyl hydrolase levels in response to changes in culture conditions revealed that glutamine enhances activity while insulin diminishes it. Other transformed cells found to secrete this protein are Hep-G2 human hepatoma, JAR human choriocarcinoma, HeLa, and rat glioma. gamma-Glutamyl hydrolase could not be detected in medium conditioned by human MCF-7 breast cancer cells, and relatively low activities were found in the medium from CCRF-CEM or K562 leukemia cells. These studies directly establish for the first time the secretion of gamma-glutamyl hydrolase in vitro.
Selective observation of the interface of heterogeneous polycarbonate/polystyrene blends by dynamic nuclear polarization carbon-13 NMR spectroscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective observation of the interface of heterogeneous polycarbonate/polystyrene blends by dynamic nuclear polarization carbon-13 NMR spectroscopyMobae Afeworki, Robert A. McKay, and Jacob SchaeferCite this: Macromolecules 1992, 25, 16, 4084–4091Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/ma00042a006https://doi.org/10.1021/ma00042a006research-articleACS PublicationsRequest reuse permissionsArticle Views545Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Asymmetric Catalysis for Carbonyl-Ene Reaction (1992)

Asymmetric catalysts ("chemzymes") for abiological transformations are complementary to natural enzymes for biological transformations. Thus, the development of asymmetric catalysis by chiral metal complexes for abiogenetic-type reactions, carbon-carbon bond formations in particular, is the most challenging and formidable endeavor for synthetic organic chemists. Described herein are the recent developments of highly enantioselective catalysis by a chiral binaphthol-derived titanium complex for the carbonyl-ene reactions which involve carbonyl compounds as the enophiles. The striking features of the titanium catalysis are also disclosed which include the positive nonlinear effect (asymmetric amplification) and the asymmetric desymmetrization. 1. Introduction 2. Asymmetric Catalysis for Carbonyl-Ene Reactions 3. Asymmetric Catalytic Glyoxylate-Ene Reaction 3.1. Role of Molecular Sieves 3.2. Positive Nonlinear Effect (Asymmetric Amplification) 4. Asymmetric Catalytic Diels-Alder Reaction 4.1. Hetero-Diels-Alder Reaction with Glyoxylate 4.2. Diels-Alder Reaction 5. Asymmetric Desymmetrization 5.1. Asymmetric Catalytic Desymmetrization 5.2. Kinematic Resolution and Double Asymmetric Induction 6. Ene Cyclization 6.1. Asymmetric Catalytic Ene Cyclization 6.2. Desymmetrization in Ene Cyclization
Fabrication of Polymeric Substrates with Well-Defined Nanometer-Scale Topography and Tailored Surface Chemistry (2002)

Micromolding of polymers from nanopatterned silicon wafers leads to the preparation of surfaces with well-defined nanometer-scale topography and surface chemical functionality. These types of substrates will be useful for investigations of the interactions of nanostructured interfaces with biological systems. The Figure shows the optical appearance of a nematic liquid crystal anchored on topographically patterned surfaces of a polystyrene replica.
Differential medium for detecting dental plaque bacteria resembling Actinomyces viscosus and Actinomyces naeslundii (1975)

A medium for detecting colonies of Actinomyces viscosus and Actinomyces naeslundii in dental plaque samples was developed. The medium (CNAC-20) contains 20.0 mug of 3CdSO4-8H2O per ml of Columbia CNA agar base. Laboratory strains of A. viscosus grew on CNAC-20 in characteristic round, white, smooth, opaque colonies. Increasing the cadmium concentration impaired the growth of some A. viscosus strains. Stock strains of A. naeslundii and A. israelii grew in colonies of similar white, opaque morphology. The few strains of other gram-positive plaque bacteria that grew on CNAC-20 had colonies easily distinguished from those of A. viscosus. Most of the bacterial strains freshly isolated from Actinomyces-like colonies on CNAC-20 that had been inoculated with human dental plaque samples were found to have cultural characteristics consistent with previous descriptions of A. viscosus or A. naeslundii. CNAC-20 may facilitate investigations into the relationship of microaerophilic Actinomyces with the etiology of dental diseases.
Evolution of an attitude control system for body-stabilized communication spacecraft (1986)

Improvements in attitude control system autonomy and beam pointing accuracy are reviewed. The ten-year history is based on the implementation and performance of geosynchronous satellites, which utilize a momentum biased concept to provide a body-stabilized spacecraft for the communication payload. Innovations and advances in microprocessor technology enabled the attainment of improved pointing and greater autonomy. Decreasing structural frequencies associated with ever larger solar arrays are accommodated by higher order filtering and control estimators; thus, stable and accurate control performance is attained during both normal and stationkeeping operations.