gebhart/patrepeval huggingface dataset:
Diet-Genotype Interactions in the Development of the Obese, Insulin-Resistant Phenotype of C57BL/6J Mice Lacking Melanocortin-3 or -4 Receptors (2006)

Loss of brain melanocortin receptors (Mc3rKO and Mc4rKO) causes increased adiposity and exacerbates diet-induced obesity (DIO). Little is known about how Mc3r or Mc4r genotype, diet, and obesity affect insulin sensitivity. Insulin resistance, assessed by insulin and glucose tolerance tests, Ser(307) phosphorylation of insulin receptor substrate 1, and activation of protein kinase B, was examined in control and DIO wild-type (WT), Mc3rKO and Mc4rKO C57BL/6J mice. Mc4rKO mice were hyperphagic and had increased metabolic efficiency (weight gain per kilojoule consumed) relative to WT; both parameters increased further on high-fat diet. Obesity of Mc3rKO was more dependent on fat intake, involving increased metabolic efficiency. Fat mass of DIO Mc3rKO and Mc4rKO was similar, although Mc4rKO gained weight more rapidly. Mc4rKO develop hepatic insulin resistance and severe hepatic steatosis with obesity, independent of diet. DIO caused further deterioration of insulin action in Mc4rKO of either sex and, in male Mc3rKO, compared with controls, associated with increased fasting insulin, severe glucose intolerance, and reduced insulin signaling in muscle and adipose tissue. DIO female Mc3rKO exhibited very modest perturbations in glucose metabolism and insulin sensitivity. Consistent with previous data suggesting impaired fat oxidation, both Mc3rKO and Mc4rKO had reduced muscle oxidative metabolism, a risk factor for weight gain and insulin resistance. Energy expenditure was, however, increased in Mc4rKO compared with Mc3rKO and controls, perhaps due to hyperphagia and metabolic costs associated with rapid growth. In summary, DIO affects insulin sensitivity more severely in Mc4rKO compared with Mc3rKO, perhaps due to a more positive energy balance.
Usefulness of presepsin (sCD14-ST) measurements as a marker for the diagnosis and severity of sepsis in systemic inflammatory response syndrome (2011)

CD14 is present in macrophage, monocyte, and granulo-cyte cells and their cell membranes, and is said to be responsible for intracellular transduction of endotoxin signals. Its soluble fraction is present in blood and is thought to be produced in association with infections. It is called the soluble CD14 subtype (sCD14-ST), and in the text below it will be referred to by its generic name, presepsin. We have previously reported that presepsin is produced in association with infection and that it is specifically expressed in sepsis. In the present study we developed a new rapid diagnostic method using a chemiluminescent enzyme immunoassay, and it made automated measurements in a shorter time possible.
Corrections and a Change to List of Common Names of Insects, 1970 (1971)

Journal Article Corrections and a Change to List of Common Names of Insects, 1970 Get access C. C. Blickenstaff C. C. Blickenstaff Search for other works by this author on: Oxford Academic Google Scholar Bulletin of the Entomological Society of America, Volume 17, Issue 4, 15 December 1971, Page 287, https://doi.org/10.1093/besa/17.4.287 Published: 15 December 1971
Nitrate Reduction by the Ultraviolet-Sulfite Advanced Reduction Process (2021)

Advanced reduction processes (ARPs) form highly reactive reducing radicals and aqueous electrons, which can reduce oxidized contaminants, by activating reducing agents. Experiments were conducted to investigate the kinetics of nitrate degradation by the sulfite/ultraviolet (UV) ARP, which has been proven to be the most effective ARP. Experimental variables were pH, UV (253.7 nm) intensity, and sulfite concentration. Rate of nitrate reduction increases with increasing pH, UV intensity, and initial sulfite concentration. The efficiency of photochemical degradation of nitrate (quantum yield based on overall reaction rate) was unaffected by UV intensity, but decreased with pH and initial sulfite concentration. Nitrite was identified as a major intermediate product of nitrate mineralization by the UV/sulfite ARP, which was simultaneously degraded along with nitrate.
System architecture for free-viewpoint video and 3D-TV (2008)

This paper presents a system architecture of an acquisition, compression and rendering system for 3D- TV and free-viewpoint video applications. We show that the proposed system yields two distinct advantages. First, it achieves an efficient compression of 3D/multi-view video by extending a standard H.264 encoder such that near backward compatibility is retained. Second, the proposed system can efficiently compress both 3D-TV and free- viewpoint multi-view video datasets using the single proposed system architecture.
Soluble MHC-peptide complexes: tools for the monitoring of T cell responses in clinical trials and basic research. (2009)

Soluble MHC-peptide complexes, commonly known as tetramers, allow the detection and isolation of antigen-specific T cells. Although other types of soluble MHC-peptide complexes have been introduced, the most commonly used MHC class I staining reagents are those originally described by Altman and Davis. As these reagents have become an essential tool for T cell analysis, it is important to have a large repertoire of such reagents to cover a broad range of applications in cancer research and clinical trials. Our tetramer collection currently comprises 228 human and 60 mouse tetramers and new reagents are continuously being added. For the MHC II tetramers, the list currently contains 21 human (HLA-DR, DQ and DP) and 5 mouse (I-A(b)) tetramers. Quantitative enumeration of antigen-specific T cells by tetramer staining, especially at low frequencies, critically depends on the quality of the tetramers and on the staining procedures. For conclusive longitudinal monitoring, standardized reagents and analysis protocols need to be used. This is especially true for the monitoring of antigen-specific CD4+ T cells, as there are large variations in the quality of MHC II tetramers and staining conditions. This commentary provides an overview of our tetramer collection and indications on how tetramers should be used to obtain optimal results.
ACM-Based Automatic Liver Segmentation From 3-D CT Images by Combining Multiple Atlases and Improved Mean-Shift Techniques (2013)

In this paper, we present an autocontext model(ACM)-based automatic liver segmentation algorithm, which combines ACM, multiatlases, and mean-shift techniques to segment liver from 3-D CT images. Our algorithm is a learning-based method and can be divided into two stages. At the first stage, i.e., the training stage, ACM is performed to learn a sequence of classifiers in each atlas space (based on each atlas and other aligned atlases). With the use of multiple atlases, multiple sequences of ACM-based classifiers are obtained. At the second stage, i.e., the segmentation stage, the test image will be segmented in each atlas space by applying each sequence of ACM-based classifiers. The final segmentation result will be obtained by fusing segmentation results from all atlas spaces via a multiclassifier fusion technique. Specially, in order to speed up segmentation, given a test image, we first use an improved mean-shift algorithm to perform over-segmentation and then implement the region-based image labeling instead of the original inefficient pixel-based image labeling. The proposed method is evaluated on the datasets of MICCAI 2007 liver segmentation challenge. The experimental results show that the average volume overlap error and the average surface distance achieved by our method are 8.3% and 1.5 m, respectively, which are comparable to the results reported in the existing state-of-the-art work on liver segmentation.
In Situ Spectroscopic Investigation of Molecular Structures of Highly Dispersed Vanadium Oxide on Silica under Various Conditions (1998)

The molecularly dispersed V2O5/SiO2 supported oxides were prepared by the incipient wetness impregnation of 2-propanol solutions of V-isopropoxide. The experimental maximum dispersion of surface vanadium oxide species on SiO2 was achieved at ∼12 wt % V2O5 (∼2.6 V atoms/nm2). The surface structures of the molecularly dispersed V2O5/SiO2 samples under various conditions were extensively investigated by in situ Raman, UV−vis−NIR DRS and XANES spectroscopies. The combined characterization techniques revealed that in the dehydrated state only isolated VO4 species are present on the silica surface up to monolayer coverage. Interestingly, the three-member siloxane rings on the silica surface appear to be the most favorable sites for anchoring the isolated, three-legged (SiO)3VO species. Hydration dramatically changes the molecular structure of the surface vanadium oxide species. The specific structure of the hydrated surface vanadium oxide species is dependent on the degree of hydration. The molecular structure of the fully hydrated vanadium oxide species closely resembles V2O5·nH2O gels, rather than V2O5 crystallites. The fully hydrated surface vanadium oxide species are proposed to be chain and/or two-dimensional polymers with highly distorted square-pyramidal VO5 connected by V−OH−V bridges, which are stabilized on the silica surface by the sixth neighbor of Si−OH hydroxyls via Si−OH···V hydrogen bonds. In analogy to the hydration process, alcoholysis occurs during methanol chemisorption, and similar molecular structures are proposed to interpret the interaction between methanol molecules and the surface vanadium oxide species on silica.
Fever risk higher when flu, pneumococcal vaccines given together (2014)

♦ [Stockwell MS. JAMA Pediatr . 2014;168:211-219][1].

Children who received trivalent inactivated influenza vaccine (TIV) and 13-valent pneumococcal vaccine (PCV13) at the same visit had a higher risk of fever than those who received just one of the vaccines, according to a prospective study of
Resveratrol blocks interleukin-1β–induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells (2003)

Resveratrol, an edible polyphenolic stilbene, has been reported to possess substantial antileukemic activities in different leukemia cell lines. We investigated whether resveratrol is active against fresh acute myeloid leukemia (AML) cells and its mechanism of action. Because interleukin 1beta(IL-1beta) plays a key role in proliferation of AML cells, we first tested the effect of resveratrol on the AML cell lines OCIM2 and OCI/AML3, both of which produce IL-1beta and proliferate in response to it. Resveratrol inhibited proliferation of both cell lines in a dose-dependent fashion (5-75 microM) by arresting the cells at S phase, thus preventing their progression through the cell cycle; IL-1beta partially reversed this inhibitory effect. Resveratrol significantly reduced production of IL-1beta in OCIM2 cells. It also suppressed the IL-1beta-induced activation of transcription factor nuclear factor kappaB (NF-kappaB), which modulates an array of signals controlling cellular survival, proliferation, and cytokine production. Indeed, incubation of OCIM2 cells with resveratrol resulted in apoptotic cell death. Because caspase inhibitors Ac-DEVD-CHO or z-DEVD-FMK partially reversed the antiproliferative effect of resveratrol, we tested its effect on the caspase pathway and found that resveratrol induced the activation of the cysteine protease caspase 3 and subsequent cleavage of the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase. Finally, resveratrol suppressed colony-forming cell proliferation of fresh AML marrow cells from 5 patients with newly diagnosed AML in a dose-dependent fashion. Taken together, our data showing that resveratrol is an effective in vitro inhibitor of AML cells suggest that this compound may have a role in future therapies for AML.
Use of the Ireland-Claisen Rearrangement in the Synthesis of 2,3-Disubstituted Succinates (1998)

The Ireland-Claisen rearrangement was employed in a convenient one-pot stereoselective procedure for the synthesis of 2,3-disubstituted succinates (1).
Bodgies and Widgies — youth cultures in the 1950s∗ (1984)

(1984). Bodgies and Widgies — youth cultures in the 1950s. Journal of Australian Studies: Vol. 8, No. 15, pp. 10-24.
Effect of zinc on human sperm motility and the acrosome reaction (1992)

This study has assessed the effect of zinc on human sperm motility and the acrosome reaction in vitro. Progressively motile human sperm were selected by swim-up and by glass bead columns and then incubated in a medium in which capacitation happened in an asynchronous way. Different doses of zinc (1, 10, 100 and 1000 microM) were added for periods of 2, 4 or 6 h. Other samples were incubated with zinc (1000 microM), and after 1 h incubation, the zinc was removed. Aliquots of each culture were used to evaluate progressive motility and the acrosome reaction using a triple-stain technique. Sperm motility was reduced when the amount of zinc added was greater than or equal to 100 microM, and these doses also caused a significant reduction in the % of sperm undergoing the acrosome reaction. After removal of zinc and further incubation in zinc-free medium for 1 h, an increase in the percentage of motile and acrosome-reacted sperm was observed. However, the increase in acrosome reaction did not reach the values observed in controls. Results suggest that extracellular zinc acts as an inhibitor of human sperm motility and the acrosome reaction (and/or capacitation and the acrosome reaction). This inhibitory effect is reversible and occurs in a dose-dependent fashion. The probable mechanisms involved are discussed.
Electrooptic Bragg diffraction switches in a low cross-talk integrated-optic switching matrix (1981)

A switching matrix using electrooptic Bragg diffraction switches in a planar waveguide is described. Low cross talk is obtained because the wave propagation in a planar waveguide eliminates all waveguide junctions. Furthermore, the connections between input and output ports are formed by using the on position of the Bragg diffraction switches only. In their off position, the electrooptic Bragg diffraction switches do not adversely affect the laser beams which propagate through it.
CyberLogic (1970)

The rapid advance of technology during recent years has made possible the development and use of very complex manufacturing processes. A prime example of such a process is a modern oil refinery in which there are actually many processes operating concurrently. The control of such a process requires the monitoring of pressures, temperatures, flow rates, and other such variables at many points within the refinery. Based on an analysis of the variables sampled, the process is controlled by adjusting flow rates, opening and closing valves, and recording the actions taken for further analysis and evaluation of the results of such actions.
Scan Architecture With Mutually Exclusive Scan Segment Activation for Shift- and Capture-Power Reduction (2004)

Power dissipation during scan testing is becoming an important concern as design sizes and gate densities increase. While several approaches have been recently proposed for reducing power dissipation during the shift cycle (minimum-transition don't care fill, special scan cells, and scan chain partitioning), limited work has been carried out toward reducing the peak power during test response capture and the few existing approaches for reducing capture power rely on complex automatic test pattern generation (ATPG) algorithms. This paper proposes a scan architecture with mutually exclusive scan segment activation which overcomes the shortcomings of previous approaches. The proposed architecture achieves both shift and capture-power reduction with no impact on the performance of the design, and with minimal impact on area and testing time (typically 2%-3%). An algorithmic procedure for assigning flip-flops to scan segments enables reuse of test patterns generated by standard ATPG tools. An implementation of the proposed method had been integrated into an automated design flow using commercial synthesis and simulation tools which was used on a wide range of benchmark designs. Reductions up to 57% in average power, and up to 44% and 34% in peak-power dissipation during shift and capture cycles, respectively, were obtained when using two scan segments. Increasing the number of scan segments to six leads to reductions of 96% and 80% in average power and, respectively, maximum number of simultaneous transitions.
Miropeats: graphical DNA sequence comparisons (1995)

Miropeats displays DNA sequence similarity information graphically. The program discovers regions of similarity amongst any set of DNA sequences and then draws a graphic that summarizes the length, location and relative orientations of any repeated sequences. Sequence similarity searching is a very general tool that forms the basis of many different biological sequence analyses but it is limited by the verbosity of traditional alignment presentation styles. Miropeats enhances the utility of conventional DNA sequence comparisons when looking at long lengths of sequence similarity by summarizing large-scale sequence similarities on a single page of PostScript graphics. Miropeats has been applied estensively to help understand shotgun assembly projects, to check cosmid overlaps and to perform inter-genomic comparisons.
Detection of Enzymatically Generated Hydrogen Peroxide by Metal-Based Fluorescent Probe (2011)

We developed a metal-based fluorescent probe for H(2)O(2) called MBFh1, which has an iron complex as a reaction site for H(2)O(2) and a 3,7-dihydroxyphenoxazine derivative as the fluorescent reporter unit. The iron complex reacts quickly with H(2)O(2) to form oxidants, and then the oxidants convert the closely appended nonfluorescent 3,7-dihydroxyphenoxazine moiety to resorufin in an intramolecular fashion. The quick response to H(2)O(2) allows us to plot the enzymatic evolution of H(2)O(2). A combination of N-acetyl-3,7-dihydroxyphenoxazine and horseradish peroxidase has been frequently used to detect enzymatically generated H(2)O(2), but this method has interference with phenol derivatives. The use of MBFh1 overcomes this drawback.
Interleukin-10 and the immune response against cancer: a counterpoint (2005)

Although interleukin-10 (IL-10) is commonly regarded as an anti-inflammatory, immunosuppressive cytokine that favors tumor escape from immune surveillance, a wealth of evidence is accumulating that IL-10 also possesses some immunostimulating properties. In fact, IL-10 has the pleiotropic ability of influencing positively and negatively the function of innate and adaptive immunity in different experimental models, which makes it questionable to merely categorize this cytokine as a target of anti-immune escape therapeutic strategies or rather, as an immunological adjuvant in the fight against cancer. Here, we review available data about the immunostimulating anticancer properties of IL-10, and in particular, we focus on the hypothesis that in contrast to what occurs in secondary lymphoid organs, IL-10 overexpression within the tumor microenvironment may catalyze cancer immune rejection.
Hydrothermal synthesis and characterisation of perovskite BaZn1/3Ta2/3O3 (1999)

The hydrothermal synthesis of BaZn 1/3 Ta 2/3 O 3 has been investigated. Whilst it was relatively straightforward to produce particles having the desired perovskite phase, these particles were deficient in Ba and Zn and correspondingly rich in Ta; some of the excess Zn was precipitated as ZnO. The effects of the metal ion and base concentrations were studied and these were found to affect profoundly the morphology, stoichiometry and crystal structure of the particles. At sufficiently low values of the base concentration, a BaTa 2 O 6 type phase was produced instead of the perovskite phase. The data from this study were then used to create a stability diagram showing the regions of stability of the perovskite and BaTa 2 O 6 type phases with respect to the base concentration and the total metal ion concentration.
Coinfection with Three<i>Ehrlichia</i>Species in Dogs from Thailand and Venezuela with Emphasis on Consideration of 16S Ribosomal DNA Secondary Structure (2001)

As part of a larger study to investigate tick-borne infections in dogs from Thailand and Venezuela, documentation of coinfection with three Ehrlichia species in two dogs, one from each country, became the focus of the present study. Although neither dog had clinical signs attributable to ehrlichiosis, both dogs were anemic and neutropenic and the Thai dog was thrombocytopenic. Genus- and species-specific PCR targeting the 16S rRNA genes indicated that both dogs were coinfected with Ehrlichia canis, E. platys, and E. equi. To our knowledge, these results provide the first molecular documentation for the presence of E. equi in dogs from these countries. Using universal bacterial PCR primers, one nearly full-length 16S rRNA gene could be amplified from each dog. The sequences were identical to each other and almost identical to that of E. platys (AF156784), providing the first E. platys 16S ribosomal DNA (rDNA) sequences reported from these two geographically divergent countries. To determine whether these sequence differences allow differentiation between these two strains and other published 16S rDNA E. platys sequences, we performed a phylogenetic analysis of the rRNA, incorporating the consideration of secondary structure.
Stakeholder identification of advanced technology opportunities at international ports of entry (1997)

As part of the Advanced Technologies for International and Intermodal Ports of Entry (ATIPE) Project, a diverse group of stakeholders was engaged to help identify problems experienced at inland international border crossings, particularly those at the US-Mexican border. The fundamental issue at international ports of entry is reducing transit time through the required documentation and inspection processes. Examples of other issues or problems, typically manifested as time delays at border crossings, repeatedly mentioned by stakeholders include: (1) lack of document standardization; (2) failure to standardize inspection processes; (3) inadequate information and communications systems; (4) manual fee and tariff collection; (5) inconsistency of processes and procedures; and (6) suboptimal cooperation among governmental agencies. Most of these issues can be addressed to some extent by the development of advanced technologies with the objective of allowing ports of entry to become more efficient while being more effective. Three categories of technologies were unambiguously of high priority to port of entry stakeholders: (1) automated documentation; (2) systems integration; and (3) vehicle and cargo tracking. Together, these technologies represent many of the technical components necessary for pre-clearance of freight approaching international ports of entry. Integration of vehicle and cargo tracking systems with port of entry information and communications systems, as well as existing industry legacy systems, should further enable border crossings to be accomplished consistently with optimal processing times.
Automatic Mood Classification Using Tf*Idf Based On Lyrics. (2010)

[TODO] Add abstract here.
Ultrastructural and chemical distinction of melanins formed by <i>Verticillium dahliae</i> from (+)-scytalone, 1,8-dihydroxynaphthalene, catechol, and <scp>L</scp>-3,4-dihydroxyphenylalanine (1978)

Microsclerotia of three melanin-deficient mutants of Verticillium dahliae formed malanin from (+)-scytalone, 1,8-dihydroxynaphthalene, catechol, and L-3,4-dihydroxyphenylalanine. The melanins formed from (+)-scytalone or 1,8-dihydroxynaphthalene resembled wild-type melanin chemically and ultrastructurally, whereas the melanins formed from catechol and L-3,4-dihydroxyphenlalanine were different. This suggests that scytalone and 1,8-dihydroxynaphthalene but no catechol or L-3,4-dihydroxyphenylalanine are natural intermediates of melanin biosynthesis in V. dahliae.