gebhart/patrepeval huggingface dataset:
Primary mediastinal B-cell lymphoma: biology and evolving therapeutic strategies (2017)

Primary mediastinal B-cell lymphoma (PMBCL) is recognized as a distinct clinicopathologic entity that predominantly affects adolescents and young adults and is more common in female subjects. Although PMBCL is considered to be a subtype of diffuse large B-cell lymphoma, its clinical, morphologic, and biological characteristics overlap significantly with those of nodular sclerosing Hodgkin lymphoma (NSHL). Over the past few years, the shared biology of these 2 entities has been highlighted in several studies, and mediastinal gray zone lymphoma, with features intermediate between PMBCL and NSHL, has been recognized as a unique molecular entity. Although there is a lack of consensus about the optimal therapeutic strategy for adolescent and young adult patients newly diagnosed with PMCBL, highly curative strategies that obviate the need for mediastinal radiation are favored by most. Progress in understanding the biology of PMBCL and its close relationship to NSHL have helped pave the way for the investigation of novel approaches such as immune checkpoint inhibition. Other strategies such as adoptive T-cell therapy and targeting CD30 are also being studied.
The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission (2002)

Yeast mitochondrial fission is a multistep process during which the dynamin-related GTPase, Dnm1p, assembles into punctate structures that associate with the outer mitochondrial membrane and mediate mitochondrial division. Steps in the Dnm1p-dependent process of fission are regulated by the actions of the WD repeat protein, Mdv1p, and the mitochondrial outer membrane protein, Fis1p. Our previous studies suggested a model where Mdv1p functions to regulate fission at a post-Dnm1p assembly step and Fis1p functions at two distinct steps, at an early point, to regulate Dnm1p assembly, and later, together with Mdv1p, to facilitate Dnm1p-dependent mitochondrial fission. To test this model, we have examined the physical and functional relationship between Mdv1p and Fis1p and present genetic, biochemical, and two-hybrid data indicating that a Fis1p-Mdv1p complex is required to regulate mitochondrial fission. To further define the role of Mdv1p in fission, we examined the structural features of Mdv1p required for its interactions with Dnm1p and Fis1p. Data from two-hybrid analyses and GFP-tagged domains of Mdv1p indicate that it contains two functionally distinct domains that enable it to function as a molecular adaptor to regulate sequential interactions between Dnm1p and Fis1p and catalyze a rate-limiting step in mitochondrial fission.
Less Regret via Online Conditioning (2010)

We analyze and evaluate an online gradient descent algorithm with adaptive per-coordinate adjustment of learning rates. Our algorithm can be thought of as an online version of batch gradient descent with a diagonal preconditioner. This approach leads to regret bounds that are stronger than those of standard online gradient descent for general online convex optimization problems. Experimentally, we show that our algorithm is competitive with state-of-the-art algorithms for large scale machine learning problems.
Dynamic inversion of a flight critical actuator for fault diagnosis (2013)

This article consists of a collection of slides from the author's conference presentation.
Variability of the Acute Toxicity of Drilling Fluids to Mysids <i>(Mysidopsis bahia)</i> (1988)

Numerous factors affect the acute toxicity of drilling fluids (muds) to mysids (Mysidopsis bahia). The source, composition, and age of drilling fluid sample; preparation of test material; condition of test animals; and skill and experience of the people conducting the tests can influence test results. Despite these confounding factors, our intralaboratory variation of median lethal concentrations (96-h LC50s) for six tests with a laboratory-prepared generic drilling fluid was within a factor of two; interlaboratory variation for seven commercial laboratories that tested the same generic drilling fluid was within a factor of four, the same as reported in the literature for acute toxicity tests with single chemicals. The presence of petroleum hydrocarbons in drilling fluids greatly increases toxicity and, because toxic, volatile fractions may be lost, the variability of results from tests with petroleum hydrocarbon-contaminated drilling fluids may be greater than that stated above.
A Survey of Radial Methods for Information Visualization (2009)

Radial visualization, or the practice of displaying data in a circular or elliptical pattern, is an increasingly common technique in information visualization research. In spite of its prevalence, little work has been done to study this visualization paradigm as a methodology in its own right. We provide a historical review of radial visualization, tracing it to its roots in centuries-old statistical graphics. We then identify the types of problem domains to which modern radial visualization techniques have been applied. A taxonomy for radial visualization is proposed in the form of seven design patterns encompassing nearly all recent works in this area. From an analysis of these patterns, we distill a series of design considerations that system builders can use to create new visualizations that address aspects of the design space that have not yet been explored. It is hoped that our taxonomy will provide a framework for facilitating discourse among researchers and stimulate the development of additional theories and systems involving radial visualization as a distinct design metaphor.
SPECTRAL DENSITY ESTIMATION AND ROBUST HYPOTHESIS TESTING USING STEEP ORIGIN KERNELS WITHOUT TRUNCATION* (2006)

A new class of kernels for long‐run variance and spectral density estimation is developed by exponentiating traditional quadratic kernels. Depending on whether the exponent parameter is allowed to grow with the sample size, we establish different asymptotic approximations to the sampling distribution of the proposed estimators. When the exponent is passed to infinity with the sample size, the new estimator is consistent and shown to be asymptotically normal. When the exponent is fixed, the new estimator is inconsistent and has a nonstandard limiting distribution. It is shown via Monte Carlo experiments that, when the chosen exponent is small in practical applications, the nonstandard limit theory provides better approximations to the finite sample distributions of the spectral density estimator and the associated test statistic in regression settings.
Calixarenes: paradoxes and paradigms in molecular baskets (1990)

Abstract
Interface engineered HfO<sub>2</sub>-based 3D vertical ReRAM (2016)

We demonstrate a double-layer 3D vertical resistive random access memory (ReRAM) stack implementing a Pt/HfO2/TiN memory cell. The HfO2 switching layer is grown by atomic layer deposition on the sidewall of a SiO2/TiN/SiO2/TiN/SiO2 multilayer pillar. A steep vertical profile was achieved using CMOS-compatible TiN dry etching. We employ in situ TiN bottom interface engineering by ozone, which results in (a) significant forming voltage reduction which allows for forming-free operation in AC pulsed mode, and (b) non-linearity tuning of low resistance state by current compliance during Set operation. The vertical ReRAM shows excellent read and write disturb immunity between vertically stacked cells, retention over 104 s and excellent switching stability at 400 K. Endurance of 107 write cycles was achieved using 100 ns wide AC pulses while fast switching speed using pulses of only 10 ns width is also demonstrated. The active switching region was evaluated to be located closer to the bottom interface which allows for the observed high endurance.
Spread Spectrum Receiver Using Surface Acoustic Wave Technology (1977)

In this paper, various potential implementations of spread spectrum systems using surface acoustic wave (SAW) devices are discussed and experimental results for a phase-shift keyed (PSK) signal embedded in unwanted interference is presented. An overview of acoustic surface wave technology as it applies to signal processing in spread spectrum communication systems is presented. The ability to implement most of the basic elements of such systems using SAW devices is discussed, with emphasis on the space charge coupled convolver and Fourier transformer. SAW implementation of a fairly general block diagram applicable to a variety of signal and interference situations is described, and the relative advantages of SAW technology with respect to other technologies such as charge coupled devices is discussed.
Genetic Engineering for Modern Agriculture: Challenges and Perspectives (2010)

Abiotic stress conditions such as drought, heat, or salinity cause extensive losses to agricultural production worldwide. Progress in generating transgenic crops with enhanced tolerance to abiotic stresses has nevertheless been slow. The complex field environment with its heterogenic conditions, abiotic stress combinations, and global climatic changes are but a few of the challenges facing modern agriculture. A combination of approaches will likely be needed to significantly improve the abiotic stress tolerance of crops in the field. These will include mechanistic understanding and subsequent utilization of stress response and stress acclimation networks, with careful attention to field growth conditions, extensive testing in the laboratory, greenhouse, and the field; the use of innovative approaches that take into consideration the genetic background and physiology of different crops; the use of enzymes and proteins from other organisms; and the integration of QTL mapping and other genetic and breeding tools.
How far can we go with structural mass spectrometry of protein complexes? (2010)

Physical interactions between proteins and the formation of stable complexes form the basis of most biological functions. Therefore, a critical step toward understanding the integrated workings of the cell is to determine the structure of protein complexes, and reveal how their structural organization dictates function. Studying the three-dimensional organization of protein assemblies, however, represents a major challenge for structural biologists, due to the large size of the complexes, their heterogeneous composition, their flexibility, and their asymmetric structure. In the last decade, mass spectrometry has proven to be a valuable tool for analyzing such noncovalent complexes. Here, I illustrate the breadth of structural information that can be obtained from this approach, and the steps taken to elucidate the stoichiometry, topology, packing, dynamics, and shape of protein complexes. In addition, I illustrate the challenges that lie ahead, and the future directions toward which the field might be heading.
Behavior disorders of dementia: recognition and treatment. (2006)

Psychosis may pose a greater challenge than cognitive decline for patients with dementia and their caregivers. The nature and frequency of psychotic symptoms varies over the course of illness, but in most patients, these symptoms occur more often in the later stages of disease. Management of psychosis requires a comprehensive nonpharmacologic and pharmacologic approach, including an accurate assessment of symptoms, awareness of the environment in which they occur, and identification of precipitants and how they affect patients and their caregivers. Nonpharmacologic interventions include counseling the caregiver about the nonintentional nature of the psychotic features and offering coping strategies. Approaches for the patient involve behavior modification; appropriate use of sensory intervention; environmental safety; and maintenance of routines such as providing meals, exercise, and sleep on a consistent basis. Pharmacologic treatments should be governed by a "start low, go slow" philosophy; a monosequential approach is recommended, in which a single agent is titrated until the targeted behavior is reduced, side effects become intolerable, or the maximal dosage is achieved. Atypical antipsychotics have the greatest effectiveness and are best tolerated. Second-line medications include typical antipsychotics for short-term therapy; and, less often, anticonvulsants, acetylcholinesterase inhibitors, antidepressants, and anxiolytics. Goals of treatment should include symptom reduction and preservation of quality of life.
Classification of Security Operation Centers (2013)

Security Operation Centers (SOCs) are a necessary service for organisations that want to address compliance and threat management. While there are frameworks in existence that addresses the technology aspects of these services, a holistic framework addressing processes, staffing and technology currently do not exist. Additionally, it would be useful for organizations and constituents considering building, buying or selling these services to measure the effectiveness and maturity of the provided services. In this paper, we propose a classification and rating scheme for SOC services, evaluating both the capabilities and the maturity of the services offered.
LEADER Recommendations for Specifying EM Wave Irradiation Conditions in Bioeffects Research<sup>*</sup> (1975)

"LEADER Recommendations for Specifying EM Wave Irradiation Conditions in Bioeffects Research*." Journal of Microwave Power, 10(3), pp. 249–250
Safety and translation of relational calculus (1991)

Not all queries in relational calculus can be answered sensibly when disjunction, negation, and universal quantification are allowed. The class of relation calculus queries or formulas that have sensible answers is called the domain independent class which is known to be undecidable. Subsequent research has focused on identifying large decidable subclasses of domain independent formulas. In this paper we investigate the properties of two such classes: the evaluable formulas and the allowed formulas. Although both classes have been defined before, we give simplified definitions, present short proofs of their main properties, and describe a method to incorporate equality. Although evaluable queries have sensible answers, it is not straightforward to compute them efficiently or correctly. We introduce relational algebra normal form for formulas from which form the correct translation into relational algebra is trivial. We give algorithms to transform an evaluable formula into an equivalent allowed formula and from there into relational algebra normal form. Our algorithms avoid use of the so-called Dom relation, consisting of all constants appearing in the database or the query. Finally, we describe a restriction under which every domain independent formula is evaluable and argue that the class of evaluable formulas is the largest decidable subclass of the domain independent formulas that can be efficiently recognized.
Inflatable and Warpable Wings for Meso-Scale UAVs (2005)

The paper presents work on testing of inflatable wings for unmanned aerial vehicles (UAVs). Design and construction of inflatable wings is discussed, along with ground and flight testing. Predictions and correlations of the forces required to warp (twist) the wings to a particular shape and the aerodynamic forces generated by that shape change are presented. The focus is on characterizing the deformation of the wings and development of a system to deform the wings inflight. Relations between wing stiness and internal pressure and the impact of external loads are presented. Mechanical manipulation of the wing shape on a test vehicle is shown to be an eective means of roll control. Finally, damage resistance is shown from results of flight tests.
α-MnO2 nanowires as building blocks for the construction of 3D macro-assemblies (2012)

A 3D macro-assembly with α-MnO(2) nanowires as flexible building blocks was obtained by a simple hydrothermal method. The sample with an interconnected open porous structure shows excellent mechanical strength, selective adsorption of cationic dyes and some certain types of toxic heavy metal ions.
Gestures à Go Go (2015)

Training a high-quality gesture recognizer requires providing a large number of examples to enable good performance on unseen, future data. However, recruiting participants, data collection, and labeling, etc., necessary for achieving this goal are usually time consuming and expensive. Thus, it is important to investigate how to empower developers to quickly collect gesture samples for improving UI usage and user experience. In response to this need, we introduce Gestures à Go Go ( g 3), a web service plus an accompanying web application for bootstrapping stroke gesture samples based on the kinematic theory of rapid human movements. The user only has to provide a gesture example once, and g 3 will create a model of that gesture. Then, by introducing local and global perturbations to the model parameters, g 3 generates from tens to thousands of synthetic human-like samples. Through a comprehensive evaluation, we show that synthesized gestures perform equally similar to gestures generated by human users. Ultimately, this work informs our understanding of designing better user interfaces that are driven by gestures.
Investigation of the impact of grain boundary on threshold voltage of 3-D MLC NAND flash memory (2015)

Three-dimensional (3-D) NAND flash technology has been attracting much attention in recent years, for it overcomes the challenges of scaling limitation faced by 2-D NAND flash and meets the demand of higher storage density and lower bit cost. Several 3-D NAND flash architectures has been proposed recently. [1-3] However, most of these structures have adopted poly-crystalline silicon (poly-Si) as the channel material, which has interface traps distributing along the random grain boundary (GB). Previous study has shown that these GB traps can cause the fluctuations in electrical characteristics and result in a wider distribution of threshold voltage (V th ) for NAND flash memory [4], [5], where only the intrinsic V th of the memory structure is analyzed. In this paper, we utilize 3-D simulation to examine the impact of GB with various positions on V th of different storage states in a multi-level cell (MLC) NAND flash memory.
Temporal Trends in Survival and Healthcare Costs in Patients with Multiple Myeloma in the United States. (2018)

The percent decrease in mortality in patients with multiple myeloma has been greater than the percent increase in healthcare costs in recent years, which may be attributable to improved treatments for multiple myeloma and changes in disease management. With the mortality rate having decreased more than the increase in healthcare costs over the same time period, the results of this study suggest that although healthcare spending has increased over time, there is a survival benefit.
Large vocabulary isolated words recognizer on a cellular array processor (2003)

The real-time implementation of a dynamic-time-warping (DTW)-based isolated-word recognizer on the general-purpose, cellular array processor (CAP) chip ACIIM is described. In this implementation a single CAP performs both the preprocessing and the DTW computations. The front end is based on a parallel filter bank. The DTW computation proceeds on a diagonal basis, each diagonal being computed by the array of 16 processors contained in the CAP. The time needed for a diagonal computation is 10.5 mu s. with a pipelined structure in the reference templates more than 800 DTW comparisons can be computed in 600 ms, assuming an average word duration of 0.8 s.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Software synthesis shell SOFTEX/S (2003)

The SOFTEX/S includes a transformation system, based on a term rewriting system, a language DSL/C++ for defining transformation rules and a specification language for a specific software model, as well as a rule verification system which supports developing correct transformation rules. SOFTEX/S has been implemented and a program synthesis system for a state transition model SOFTEX/STM has been developed with SOFTEX/S. Based on the results of this experience, SOFTEX/S has been evaluated to improve software productivity, while maintaining the desired software quality in terms of execution speed and memory usage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Facile attachment of transition metal complexes to graphite electrodes coated with polymeric ligands. Observation and control of metal-ligand coordination among reactants confined to electrode surfaces (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile attachment of transition metal complexes to graphite electrodes coated with polymeric ligands. Observation and control of metal-ligand coordination among reactants confined to electrode surfacesNoboru Oyama and Fred C. AnsonCite this: J. Am. Chem. Soc. 1979, 101, 3, 739–741Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://doi.org/10.1021/ja00497a044Request reuse permissionsArticle Views230Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (378 KB) Get e-Alertsclose Get e-Alerts
Synthesis of <i>N</i>-Glycosides. An Alternative Approach Based on Diastereoselective Base Coupling and S<sub>N</sub>2 Cyclization (2001)

[reaction: see text] Acyclic diastereoselection is achieved for the formation of thioaminyl acetals. The highly intramolecular stereocontrolled S(N)2 displacement of the thioaminyls allows for the formation of cyclic nucleoside derivatives. This versatile approach may provide easy access to a large variety of N-glycosides.
Expanding the Scope of Protein-Detecting Electrochemical DNA “Scaffold” Sensors (2018)

The ability to measure the levels of diagnostically relevant proteins, such as antibodies, directly at the point of care could significantly impact healthcare. Thus motivated, we explore here the E-DNA "scaffold" sensing platform, a rapid, convenient, single-step means to this end. These sensors comprise a rigid nucleic acid "scaffold" attached via a flexible linker to an electrode and modified on its distal end with a redox reporter and a protein binding "recognition element". The binding of a targeted protein reduces the efficiency with which the redox reporter approaches the electrode, resulting in an easily measured signal change when the sensor is interrogated voltammetrically. Previously we have demonstrated scaffold sensors employing a range of low molecular weight haptens and linear peptides as their recognition elements. Expanding on this here we have characterized sensors employing much larger recognition elements (up to and including full length proteins) in order to (1) define the range of recognition elements suitable for use in the platform; (2) better characterize the platform's signaling mechanism to aid its design and optimization; and (3) demonstrate the analytical performance of sensors employing full-length proteins as recognition elements. In doing so we have enlarged the range of molecular targets amenable to this rapid and convenient sensing platform.