gebhart/patrepeval huggingface dataset:
Two promoter-specific host factors interact with adjacent sequences in an EIA-inducible adenovirus promoter. (1987)

We previously reported the identification of a host factor (EIIA-EF) specific for an upstream transcriptional control sequence (-82 to -66) of the EIA-inducible adenovirus EIIA early promoter. The levels of this factor remained unchanged after virus infection of human cells. Another study also identified a factor (EIIF) specific for this same promoter, but the activity of this second factor was shown to increase severalfold after virus infection. We now show that these dramatically different results, both based on gel shift assays on the same promoter, may be explained by variations in protocol details and actually identify two distinct factors. When synthetic DNA copolymers [poly(dI).poly(dC) or poly(dI-dC).poly(dI-dC)] are used as competitors in gel shift assays, a factor specific for DNA sequences between -82 and -66 can be identified, whereas when natural eukaryotic DNAs (salmon sperm or calf thymus) are used as competitors a different factor specific for DNA sequences between -69 and -33 can be identified. We have mapped the DNA-protein contact residues for the EIIF by analyzing a series of linker scan mutants in gel shift assays and methylation interference experiments. The EIIA-EF and EIIF bind to two distinct but adjacent sequences. Competition experiments indicate that these two activities are due to two different factors. Consistent with the earlier reports, the levels of one (EIIA-EF) do not change after virus infection of human cells, whereas the levels of the other (EIIF) are increased severalfold.
Design of common communication platform of microgrid (2010)

Communication system in microgrid is very important to microgrid operation. Except for meeting the demand of reliability, it should fulfill the characteristics of plug and play, dispersion in distributed devices, and the need of data information in controlling. A constraint set and a common communication platform are designed considering architecture and control of microgrid. In the process of designing platform, the IEC60870-5-104 protocol being successfully used in power system is used as reference besides the proposed constraint set. In this paper the architecture of EPA is established to meet the reliability requirements in communication. Meanwhile a common and extensible information structure is carried out based on the characteristics of microgrid's control information. An example of application shows that this communication platform can be used well in the control system of microgrid and reduce the cost for devices connect.
The SR Protein B52/SRp55 Is Essential for <i>Drosophila</i> Development (1994)

B52, also called SRp55, is a 52-kDa member of the Drosophila SR protein family of general splicing factors. Escherichia coli-produced B52 is capable of both activating splicing and affecting the alternative splice site choice in human in vitro splicing reactions. Here we report the isolation of a B52 null mutant generated by remobilizing a P element residing near the B52 gene. The resulting deletion, B52(28), is confined to the B52 gene and its neighbor the Hrb87F gene. Second-instar larvae homozygous for the deletion are deficient in both B52 mRNA and protein. The B52 null mutant is lethal at the first- and second-instar larval stages. Germ line transformation of Drosophila flies with B52 genomic DNA rescues this lethality. Thus, B52 is an essential gene and has a critical role in Drosophila development. Larvae deficient in B52 are still capable of splicing the five endogenous pre-mRNAs tested here, including both constitutively and alternatively spliced genes. Therefore, B52 is not required for all splicing in vivo. This is the first in vivo deficiency analysis of a member of the SR protein family.
Multivariate ordering in color image filtering (1991)

Multivariate data ordering and its use in color image filtering are presented. Several of the filters presented are extensions of the single-channel filters based on order statistics. The statistical analysis of the marginal order statistics is presented for the p-dimensional case. A family of multichannel filters based on multivariate data ordering, such as the marginal median, the vector median, the marginal alpha -trimmed mean, and the multichannel modified trimmed mean filter, is described in detail. The performance of the marginal median and the vector median filters in impulsive noise filtering is investigated. Simulation examples of the filters under study are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Lanoconazole and Its Related Optically Active Compound NND-502: Novel Antifungal Imidazoles with a Ketene Dithioacetal Structure (2003)

Imidazole antifungal agents have been successfully developed in medicine mainly for the treatment of superficial skin fungal infections. Through the screening for novel imidazole compounds, it was found that remarkable augmentation of in vitro antifungal activity is brought by the introduction of imidazole moiety to a unique structure ketene dithioacetal, and among these imidazole compounds (±)-(E)-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imidazolylacetonitrile (generic name: lanoconazole, CAS 101530-10-3) is now available as a topical drug used for the treatment of superficial skin fungal infections in Japan. Lanoconazole exerted 30-700 times more potent activity as measured by MICs (minimun inhibitory concentrations) against dermatophytes than did other antifungal imidazole compounds, bifonazole and clotrimazole. In therapeutic experiments using guinea pig models of infections, lanoconazole also exhibited excellent curative effect on two tinea models (tinea pedis and tinea corporis) and a cutaneous candidiasis model as compared to other reference agent, bifonazole, clotrimazole and / or tolnaftate, a thiocarbamate class of compound, in term of eradicating fungi from the infected loci. Since lanoconazole is a racemic compound and only the R-enantiomer was found to be active, extensive screening for optically active-related compound was further conducted. As a result, an optically active compound NND-502 was found to have more potent antifungal activity than lanoconazole and terbinafine, an allylamine class of antifungal agent. In an in vivo study with a guinea pig model of tinea pedis, short-term treatment regimen of topical NND-502 achieved a complete mycological cure, while that of topical lanoconazole and terbinafine did not. Furthermore, the potentiality of the compound for the oral and intravenous treatment of aspergillosis, one of the major deep-seated fungal infections, has been found out as well as for the topical treatment of dermatophytosis. The oral regimen of NND-502 in a murine model of systemic aspergillosis was apparently superior to that of itraconazole, a triazole compound, in terms of prolonging survival. Intravenous NND-502 also proved highly effective in a rat model of pulmonary aspergillosis compared with intravenous amphotericin B in terms of not only prolonging survival but also eradication of fungi from the lung. These encouraging results suggest that the related compounds of lanoconazole could bring considerable progress in the antifungal chemotherapy. Keywords: antifungal agent, Imidazole, lanoconazole, nnd-502
PANSHARPENING OF HYPERSPECTRAL IMAGES IN URBAN AREAS (2012)

Abstract. Pansharpening has proven to be a valuable method for resolution enhancement of multi-band images when spatially high-resolving panchromatic images are available in addition. In principle, pansharpening can beneficially be applied to hyperspectral images as well. But whereas the grey values of multi-spectral images comprise at most relative information about the registered intensities, calibrated hyperspectral images are supposed to provide absolute reflectivity values of the respective material surfaces. This physical significance of the hyperspectral data should be preserved within the pansharpening process as much as possible. In this paper we compare several common pansharpening methods such as Principal Component Fusion, Wavelet Fusion, Gram-Schmidt transform and investigate their applicability for hyperspectral data. Our focus is on the impact of the pansharpening on material classifications. Apart from applying common quality measures, we compare the results of material classifications from hyperspectral data, which were pansharpened by different methods. In addition we propose an alternative pansharpening method which is based on an initial segmentation of the panchromatic image with an additional use of map vector data.
Identification and mitigation of interference sources present in SSB‐based wireless MRI receiver arrays (2013)

Successful wireless transmission of multiple SSB-encoded MRI signals is possible as long as channel interference is properly managed through design and simulation.
Captopril induced reversible renal failure: a marker of renal artery stenosis affecting a solitary kidney. (1983)

<b>Objectives:</b> A growing number of epidemiological studies are showing that ambient exposure to particulate matter air pollution is a risk factor for cardiovascular disease; however, whether occupational exposure increases this risk is not clear. The aim of the present study was to examine whether occupational exposure to particulate air pollution increases the risk for ischaemic heart disease and cerebrovascular disease. <b>Methods:</b> The study population was a cohort of 176 309 occupationally exposed Swedish male construction workers and 71 778 unexposed male construction workers. The definition of exposure to inorganic dust (asbestos, man-made mineral fibres, dust from cement, concrete and quartz), wood dust, fumes (metal fumes, asphalt fumes and diesel exhaust) and gases and irritants (organic solvents and reactive chemicals) was based on a job-exposure matrix with focus on exposure in the mid-1970s. The cohort was followed from 1971 to 2002 with regard to mortality to ischaemic heart disease and cerebrovascular disease. Relative risks (RR) were obtained by the person-years method and from Poisson regression models adjusting for baseline values of blood pressure, body mass index, age and smoking habits. <b>Results:</b> Any occupational particulate air pollution was associated with an increased risk for ischemic heart disease (RR 1.13, 95% CI 1.07 to 1.19), but there was no increased risk for cerebrovascular disease (RR 0.97, 95% CI 0.88 to 1.07). There was an increased risk for ischaemic heart disease and exposure to inorganic dust (RR 1.07, 95% CI 1.03 to 1.12) and exposure to fumes (RR 1.05, 95% CI 1.00 to 1.10), especially diesel exhaust (RR 1.18, 95% CI 1.13 to 1.24). There was no significantly increased risk for cerebrovascular disease and exposure to inorganic dust, fumes or wood dust. <b>Conclusions:</b> Occupational exposure to particulate air pollution, especially diesel exhaust, among construction workers increases the risk for ischaemic heart disease.
Antitrust pitfalls in outpatient services. (1993)

Increasingly, services traditionally provided to inpatients are moving to the outpatient setting, resulting in greater antitrust risk. Antitrust issues are most likely to arise when a hospital with a large share of the inpatient market attempts to increase outpatient volume by restricting their patients' choices of outpatient providers, or when providers who control scarce outpatient resources attempt to restrict competition by denying other providers access to a facility. This trend has affected physicians both as competitors of hospitals in the outpatient services market and as participants with hospitals in ventures for the provision of outpatient care.
Challenges, Lessons Learned, and Successful Implementations of Multilateral Completion Technology Offshore Abu Dhabi (2006)

Abstract ZADCO with the supports from shareholders and the cooperation of ADMA-OPCO has successfully completed the final design of MLC (Multi-Lateral Completion) system for Reservoirs A and B through MLTBS (Multi Lateral Tie Back System) project in a re-entry well, Well T-2 in Upper Zakum field. Well - T2 was re-completed as dual lateral/dual producer from Reservoirs A and B utilizing a RDS (Re-Entry Drilling System) Ver.2 and a DBD (Dual Bore Deflector) with a latch coupling of orientation device in the 7" liner hanger assembly for each lateral access. According to TAML (Technology Advancement Multi-Lateral) level specification, the final MLC is categorized as TAML Level-4 E-2-PN-D/4-TR-SEP (Level-4, existing well application, two junctions, producer with natural lift, dual completion, tubing re-entry, separated flow). Multi-Lateral liner hanger system, i.e., accommodating a latch coupling in 7" liner hanger assembly to have a certain access to the upper lateral, was the first success application in the world. The teamwork and integrated approach for the trial planning and implementation as well as lessons learned from a pre- design trial (TAML Level-4 E-2-PN-D/4-TR-SEP using straddle assembly) for Well T-1 completed in year 2000 have led to reaching the final goal of MLC in Well T-2, which provides ZADCO with following reservoir benefits -: – Independent coiled tubing access to the upper and lower lateral of reservoir A and B through dual completion to perform effective stimulation and reservoir monitoring. – Full bore access to each lateral immediately after pulling out the completion, which is an additional feature to the pre-design of MLC for Well T-1. – Allow conducting selective water shut-off to cope with water breakthrough into the upper cased lateral and extending well life by drilling a secondary lateral from a window joint installed in the upper cased lateral. Moreover, another MLC trial using a mechanical selective through tubing re-entry equipment has been also successfully implemented in a quadrant multi-lateral well of RL-2 in 2005 after experiencing an operational failure with the similar MLC design tried in Well RL-1 during 2001. The successful trial implementations have proved that the MLC system will be able to apply for any new/re-entry well for ZADCO reservoirs, provide new methods for reservoir management, and allow creating new completion strategy for ZADCO field development. This paper will cover MLC strategy created for MLTBS project, lessons learned through the successes and failures of the MLC trials, and additional challenges planned for future.
Relationship Between Chemical Structure and Effectiveness of Some Metallic Dialkyl and Diaryldithiophosphates in Different Lubricated Mechanisms (1990)

The antiwear (AW) and extreme-pressure (EP) properties of some metallic dialkyl and diaryidithiophosphates (MDTP), including zinc, have been studied in different metal/metal contact conditions : four-ball and FZG rigs. We have noted :- With pure dialkyldithiophosphates of different divalent metals (Zn, Cd, Cu, Pb, Ni, Co), prepared from the same alcohol :(a) On the four-ball rig, EP results, expressed in terms of load-wear index, show that the highest performances are obtained with ZnDTP, but statistically the higher the ionic radius of the metal, the better the performance. EP results, expressed in terms of weld load, do not show any difference between these MDTP. (b) On the four-ball rig, AW results, expressed in terms of wear scar, show that the highest performances are obtaine with ZnDTP; beyond a certain value these performances with Zn and Pb are almost independent of the concentration. For the other metallic DTP, there is a very close relationship between performance and concentration. (c) On the FZG gear rig, EP-AW results, expressed in terms of failure load stage and specific wear, show that statistically, the higher the ionic radius of the metal, the better the performance. - With ZnDTP :(a) On the four-ball rig, EP results, expressed in terms of load wear index, do not depend on the chemical structure of the alcohol used for synthetized ZnDTP, but if results are expressed in terms of weld load, better performances are obtained with ZnDTP synthetized from secondary alcohols. AW results show that the effectiveness of ZnDTP from secondary alcohols is slightly higher when the alcohols used contain less than six carbon atoms. Beyond six carbon atoms in primary or secondary alcohol molecules, performances decrease. (b) On the FZG gear rig, EP-AW results show that performances do not depend on the primary or secondary nature of the alcohols used, and that the smaller the hydrocarbon chain of these alcohols, the better the performances. The results of this work indicate that ZnDTP is the most effective of the MDTP we have studied. For ZnDTP prepared from different alcohols and alkylphenols the performances depend not only on the chemical structure of the additive, but also on contact conditions (kinematic, material types, etc. ), and on the criteria considered (seizure load, weld load, wear, etc.
Carpal tunnel syndrome among Minnesota dental hygienists. (1990)

Because of inherent aspects of clinical practice, dental hygiene practitioners may be at risk for developing carpal tunnel syndrome (CTS). A study was conducted to determine the prevalence of CTS among dental hygienists and its effects on clinical practice. A 33-item questionnaire was mailed to a random sample of 493 dental hygienists. A 90% response rate was achieved. Results revealed that 7% of the respondents had been diagnosed as having CTS. However, 63% had experienced one or more symptoms. Six percent reported that CTS had affected their clinical practice in ways such as limiting the number of days practiced, diminishing their hand strength, or forcing them to leave the profession. The findings suggest a need for dental hygienists to obtain information on CTS symptoms to facilitate early diagnosis and treatment.
Radical Photopolymerization in Miniemulsions. Fundamental Investigations and Technical Development (2011)

A photochemical means to convert acrylate monomer emulsions into polymer nanolatexes has been explored using radical miniemulsion photopolymerization. Our aim is to offer a complete overview through a stepwise mechanistic investigation, addressing first the key aspect of the electronic excitation of the photoinitiator in monomer miniemulsions and ending with the implementation of a photochemical reactor. In a first step, the photon flux absorbed by different photochemical initiators was investigated as a function of the miniemulsion droplet size. A series of miniemulsion polymerizations were also performed and the effects of the primary experimental parameters on the reactions kinetics, molar masses, and colloidal properties were assessed. As expected, droplet size, incident photon flux, and the nature of the photochemical initiator were found to be the primary reaction parameters. Finally, miniemulsion polymerizations were performed in an annular photochemical reactor in batch and semibatch processes.
Transpiration: Water Movement through Plants (2005)

Transpiration is the loss of water from a plant in the form of water vapor. Water is absorbed by roots from the soil and transported as a liquid to the leaves via xylem. In the leaves, small pores allow water to escape as a vapor and CO 2 to enter the leaf for photosynthesis. Of all the water absorbed by plants, less than 5% remains in the plant for growth and storage following growth. This lesson will explain why plants lose so much water, the path water takes through plants, how plants might control for too much water loss to avoid stress conditions, and how the environment plays a role in water loss from plants. The objectives of this lesson are as follows: Define transpiration and explain why it occurs in plants. Follow the pathway that water takes through plants from root uptake to evaporation at leaf cell surfaces. Describe how the driving force for water movement and any resistances to its flow through the plant are the two major components controlling rates of transpiration. Describe how environmental conditions alter rates of transpiration. Explain how the plant is able to alter rates of transpiration. A bank of quiz questions targeting these objectives is a part of the lesson. The lesson is designed to meet the educational needs of undergraduates.
A Cloud-Based Framework for Supporting Effective and Efficient OLAP in Big Data Environments (2014)

Inspired by the emerging Big Data challenge, in this paper we provide the description of OLAP*, a Cloud based framework for supporting effective and efficient OLAP in Big Data environments. OLAP* combines data warehouse partitioning techniques with Cloud Computing paradigms, and provides a suitable implementation on top of the well-known ROLAP server Mondrian where the main task consists in applying meaningful transformation of multidimensional database schemas. We complement our analytical contribution by mean of a case study showing the effectiveness of our framework in a practical setting.
Thiopropanal S-oxide: a lachrymatory factor in onions (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiopropanal S-oxide: a lachrymatory factor in onionsMichael H. Brodnitz and John V. PascaleCite this: J. Agric. Food Chem. 1971, 19, 2, 269–272Publication Date (Print):March 1, 1971Publication History Published online1 May 2002Published inissue 1 March 1971https://pubs.acs.org/doi/10.1021/jf60174a009https://doi.org/10.1021/jf60174a009research-articleACS PublicationsRequest reuse permissionsArticle Views581Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interlaboratory evaluation of smoke density chamber (1971)

For the materials tested, the median coefficient of variation of reproducibility was 1 .2% under non-flaming exposure conditions and 131 under flaming exposure conditions. A discussion of errors and recommendations for improved procedures based on user experience is given. A tentative test method description is included as an appendix.
The cDNA sequence and expression analysis of CD4 in mandarin fish (Siniperca chuatsi). (2011)

The cDNA sequence of CD4 homologue was cloned from the mandarin fish Siniperca chuatsi.It consists of 2 356 bp,encoding 469 amino acids,and this molecule has a typical four Ig-like domains(V1-C1-V2-C2)and shares some fundamental conserved structures,i.e.WTC motif in D2 domain,N-glycosylation site in D4 domian and the CXC motif in the cytoplasmic tail.Unlike avian and mammalian CD4 molecules,the mandarin fish CD4 sequence lacks the Cys pairs in the first Ig-like domain,but has a unique possible disulfide bond in the third domain.These differences suggest that mandarin fish CD4 molecule may have a different structure,which may in turn influence its binding with MHC Ⅱ molecule and probably subsequent T-cell activation.The CD4 was expressed mainly in thymus,and following stimulation with LPS,its significant increase(P0.05)at mRNA level was observed 8 hours post injection in thymus,spleen and head-kidney.The mandarin fish CD4 shared a relatively high level of similarity(57%)with that in sea bass Dicentrarchus labrax,and in the phylogenetic tree,the mandarin CD4 was clustered with that in sea bass.The cloning of CD4 in the mandarin fish may serve as a basis for further functional characterization of fish T lymphocytes.