gebhart/patrepeval huggingface dataset:
Extreme supercontinuum generation to the deep UV (2012)

We report the formation of an ultrabroad supercontinuum down to 280 nm in the deep UV by pumping sharply tapered (5-30 mm taper lengths) solid-core photonic crystal fibers with 130 fs, 2 nJ pulses at 800 nm. The taper moves the point of soliton fission to a position where the core is narrower, a process that requires normal dispersion at the input face of the fiber. We find that the generation of deep-UV radiation is limited by strong two-photon absorption in the silica.
Effect of immunization against synthetic peptide sequences of bovine inhibin α-subunit on ovulation rate and twin-calving rate in heifers (1993)

Three peptide sequences from the bovine inhibin alpha-subunit (P1: 18-30; P2: 63-72 and P3: 107-122) were synthesized and conjugated to human serum albumin (HSA). Hereford cross-heifers (n = 5 per group) were injected with 3 mg of one of the peptide conjugates, followed by three booster injections at intervals of 11 weeks. Control heifers (n = 5) were injected with HSA only. Antibodies recognizing both the individual peptides and 32 kDa bovine inhibin were generated and ovulation rate was increased in peptide immunized heifers. In group P1, 1 of 5 heifers responded with an increased ovulation rate whereas in groups P2 and P3, 5 of 5 and 4 of 5 heifers, respectively, had an increased ovulation rate. In group P2, in the first oestrous cycle following booster injections 2 and 3, 4 of 5 and 3 of 5 heifers, respectively, responded with twin ovulations, whereas a fourth heifer had three ovulations following booster injection 3. After breeding following booster injection 3, 3 of 5 heifers in group P2 and 1 of 5 in group P3 gave birth to twin calves. This study demonstrates the potential of immunizing against synthetic peptide sequences of the alpha-subunit of bovine inhibin to increase ovulation and twinning rates in cattle.
COMPLEXES OF BORON TRIFLUORIDE WITH FLUOBORATES (1965)

The occurrence of complexes of boron trifluoride with some fluoborates has been established. Enthalpies of formation were determined for some of these complexes. Infrared and fluorine resonance spectra were obtained in an attempt to elucidate the structures of the complexes.
We Get it Done: How Hanover High is organized to carry on a full program under wartime difficulties (1945)

(1945). We Get it Done: How Hanover High is organized to carry on a full program under wartime difficulties. The Clearing House: A Journal of Educational Strategies, Issues and Ideas: Vol. 19, No. 6, pp. 358-359.
On the Conduction Mechanism in Ionic Glasses (2000)

The conduction mechanism in ionic glasses is still considered as one of the great challenges in physics and chemistry of glasses. We show that consequent application of the routine percolation theory within the well-known random-energy model leads to the consistent description of most puzzling conduction effects for both dc and ac conductivity. The results provide a general basis for study of transport phenomena in ionic glasses.
Polyphenols: Immunomodulatory and Therapeutic Implication in Colorectal Cancer (2019)

Polyphenolic compounds, widely present in fruits, vegetables, and cereals, have potential benefits for human health and are protective agents against the development of chronic/degenerative diseases including cancer. More recently these bioactive molecules have been gaining great interest as anti-inflammatory and immunomodulatory agents, mainly in neoplasia where the pro-inflammatory context might promote carcinogenesis. Colorectal cancer (CRC) is considered a major public healthy issue, a leading cause of cancer mortality and morbidity worldwide. Epidemiological, pre-clinical and clinical investigations have consistently highlighted important relationships between large bowel inflammation, gut microbiota (GM), and colon carcinogenesis. Many experimental studies and clinical evidence suggest that polyphenols have a relevant role in CRC chemoprevention, exhibit cytotoxic capability vs. CRC cells and induce increased sensitization to chemo/radiotherapies. These effects are most likely related to the immunomodulatory properties of polyphenols able to modulate cytokine and chemokine production and activation of immune cells. In this review we summarize recent advancements on immunomodulatory activities of polyphenols and their ability to counteract the inflammatory tumor microenvironment. We focus on potential role of natural polyphenols in increasing the cell sensitivity to colon cancer therapies, highlighting the polyphenol-based combined treatments as innovative immunomodulatory strategies to inhibit the growth of CRC.
Beclomethasone Dipropionate: A New Steroid Aerosol for the Treatment of Allergic Asthma (1972)

Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known.
Immunotherapy for Prostate Cancer (2006)

The absence of curative therapies for advanced or recurrent forms of prostate cancer has prompted a vigorous search for novel treatment strategies. Immunotherapy encompasses one particularly promising systemic approach to treat prostate cancer. Immune-based strategies to treat prostate cancer have recently been facilitated by the identification of a number of prostate tissue/tumor antigens that can be targeted, either by antibody or T cells, to promote prostate tumor cell injury or death. These same prostate antigens can also be used for the construction of vaccines to induce prostate-specific T cell-mediated immunity. Greater insight into specific mechanisms that govern antigen-specific T cell activation has brought with it a number of innovative methods to induce and enhance T cell-mediated responses against prostate tumors. For instance, autologous dendritic cells loaded with prostate antigens have proved useful to induce prostate-specific T cell activation. Similarly, in vivo manipulations of the T cell costimulatory pathway receptors can greatly facilitate tumor-specific T cell activation and potentiate T cell-mediated responses against a number of malignancies, including prostate cancer. Therefore, in this review we summarize recent advances pertaining to immunotherapeutic approaches to treat prostate cancer.
Wavelength Dependence of the Suppressed Ionization of Molecules in Strong Laser Fields (2011)

We study ionization of molecules by an intense laser field over a broad wavelength regime, ranging from 0.8 to 1.5 μm experimentally and from 0.6 to 10 μm theoretically. A reaction microscope is combined with an optical parametric amplifier to achieve ionization yields in the near-infrared wavelength regime. Calculations are done using the strong-field S-matrix theory and agreement is found between experiment and theory, showing that ionization of many molecules is suppressed compared to the ionization of atoms with identical ionization potentials at near-infrared wavelengths at around 0.8 μm, but not at longest wavelengths (10 μm). This is due to interference effects in the electron emission that are effective at low photoelectron energies but tend to average out at higher energies. We observe the transition between suppression and nonsuppression of molecular ionization in the near-infrared wavelength regime (1-5 μm).
Effect of the Combination of Methyltestosterone and Esterified Estrogens Compared with Esterified Estrogens Alone on Apolipoprotein CIII and Other Apolipoproteins in Very Low Density, Low Density, and High Density Lipoproteins in Surgically Postmenopausal Women (2004)

Androgens are known to lower plasma triglycerides, an independent risk factor for coronary heart disease (CHD). Triglycerides are carried in plasma on very low density (VLDL) and low density (LDL) lipoprotein particles. Apolipoprotein CIII (apoCIII), a strong predictor of CHD, impairs the metabolism of VLDL and LDL, contributing to increased triglycerides. The objective of this study was to assess the effect of oral methyltestosterone (2.5 mg/d), added to esterified estrogens (1.25 mg/d), on concentrations of apolipoproteins and lipoproteins, specifically those containing apoCIII, compared with esterified estrogens alone in surgically postmenopausal women. The women in the methyltestosterone plus esterified estrogen group had significant decreases in total triglycerides, apoCI, apoCII, apoCIII, apoE, and high density lipoprotein (HDL) cholesterol compared with those in the esterified estrogen group. The decreases in apoCIII concentrations occurred in VLDL (62%; P = 0.02), LDL (35%; P = 0.001), and HDL (17%; P < 0.0001). There were also decreases in cholesterol and triglycerides concentrations of apoCIII containing LDL, and apoCI concentration of apoCIII containing VLDL. There was no effect on VLDL and LDL particles that did not contain apoCIII or on apoB concentrations. In conclusion, methyltestosterone, when administered to surgically postmenopausal women taking esterified estrogen, has a selective effect to reduce the apoCIII concentration in VLDL and LDL, a predictor of CHD. Methyltestosterone may lower plasma triglycerides through a reduction in apoCIII.
Doubly Branched Hexasaccharide Epitope on the Cell Wall Polysaccharide of Group A Streptococci Recognized by Human and Rabbit Antisera (2005)

A number of epitope specificities associated with the cell wall polysaccharide antigen of group A streptococci were identified in a polyclonal rabbit antiserum induced in rabbits by whole group A streptococci and in polyclonal convalescent human antisera from children that had recovered from streptococcal A infections. The identification was achieved by using a series of synthetic oligosaccharides, glycoconjugates, and bacterial polysaccharide inhibitors to inhibit the binding of the group A helical polysaccharide to the polyclonal antisera. The exclusively dominant epitope expressed in the convalescent human antisera was the doubly branched extended helical hexasaccharide with the structure alpha-L-Rhap(1-->2)[beta-D-GlcpNAc(1-->3)]alpha-L-Rhap(1-->3)alpha-L-Rhap(1-->2)[beta-D-GlcpNAc(1-->3)]alpha-L-Rhap. The hexasaccharide epitope also bound with the highest immunoreactivity to the rabbit antiserum. In contrast, the human antisera did not show significant binding to the singly branched pentasaccharide with the structure alpha-L-Rhap(1-->2)alpha-L-Rhap(1-->3)alpha-L-Rhap(1-->2)[beta-D-GlcpNAc(1-->3)]alpha-L-Rhap or the branched trisaccharide alpha-L-Rhap(1-->2)[beta-D-GlcpNAc(1-->3)]alpha-l-Rhap, although both these haptens bound significantly to the same rabbit antiserum, albeit with less immunoreactivity than the hexasaccharide. Inhibition studies using streptococcal group A and B rabbit antisera and the inhibitors indicated above also suggested that the group A carbohydrate, unlike the group B streptococcal polysaccharide, does not contain the disaccharide alpha-L-Rhap(1-->2)alpha-L-Rhap motif at its nonreducing chain terminus, stressing the importance of mapping the determinant specificities of these two important streptococcal subcapsular group polysaccharides to fully understand the serological relationships between group A and group B streptococci.
Comment on Comment (2011)

Lee, Jiyon. 2011. Comment on Comment: The Effectiveness of Student Annotations and Teacher Feedback in L2 Business Writing. Korean Journal of English Language and Linguistics, 11-3, 547-575. This paper examines the effects of improvement in writing quality on two significant areas in L2 business writing: (1) the short term writing goals and the long term writing goals and (2) the degree of involvement in the student annotations and the teacher feedback. Student annotation training and three business-letter writing-tasks were completed over an intensive 5-week period. All the participants were college undergraduates enrolled in a prerequisite course for business writing at the College of Business in Korea. The degree of involvement in the Student Annotations, Teacher Feedback, Comment on Comment, and Reflection was found pivotal in the short term writing goals versus the long term writing goals: (1) the lower-level proficiency writers benefit from the greater degree of student involvement and higher improvement in the writing quality, (2) the degree of student involvement elicits higher frequency in teacher feedback, (3) greater degree of student involvement elicits higher frequency in the student annotations, and (4) the greater the involvement, perceptions varied between the types of student annotations and the types of teacher feedback. The results of this study indicate salience in L2 business writing research in ESP.
Design Considerations for Low-power IR-UWB Receiver and LNA (2011)

A low-power receiver topology for impulse-radio ultra wideband(IR-UWB) wireless communication system is proposed after the analysis of a variety of UWB receiver structure.The receiver structure based on non-coherent communication scheme adopts self-mixer and pulse position modulation(PPM).The wideband low noise amplifier(LNA) dominates the receiver power dissipation and therefore is critical for low-power implementation of receiver system.After comparison of different LNA topologies,an ultra-low-power LNA topology implemented with 65 nm CMOS process and powered with 1 volt power supply is proposed.The LNA with 3.1～5 GHz bandwidth only consumes 1.5 mW power.The proposed LNA performs 14.5 dB gain and 5.85 dB noise figure while the input match is better than-10 dB.
Applying and assessing two methods for measuring complexity in manufacturing (1998)

Previous work in manufacturing has identified complexity as a relevant topic in this field. However, there is a high diversity of opinions on what complexity is, why it should be measured and how this can be done. This paper aims to contribute to a better understanding of manufacturing complexity and of the relationship between the system's complexity and its performance. Firstly, we identify the various aspects of manufacturing complexity highlighted in the literature. Secondly, we describe two complementary methods for measuring complexity, and the adaptation and application of these methods in a case study. The issues involved in applying the methods and the insights gained are also discussed. The main criteria considered in assessing the two methods are: methodology, costs, feasibility, type of information required, and the type of results they provide. We conclude by outlining the requirements that a complexity assessment method must meet in order to address all the complexity issues identified.
Measurement of Dielectric Loss Using a Cut-Off Circular Waveguide Cavity (1980)

Based on a resonant cavity technique used by Hanfling and Botte, this paper describes an extension of their method for the determination of the loss tangent of dielectric materials by means of Q-factor measurements. The present method appears to be suitable for materials of low loss (tan δ < 0.001). Measurements made on Teflon samples using a modified copper cavity designed for the X-band are reported.
Predicting halfway through simulation: early scenario evaluation using intermediate features of agent-based simulations (2014)

Agent-based simulations are indisputably effective for analyzing complex processes such as traffic patterns and social systems. However, human experts often face the challenges in repeating the simulation many times when evaluating a large variety of scenarios. To reduce the computational burden, we propose an approach for inferring the end results in the middle of simulations. For each simulated scenario, we design a feature that compactly aggregates the agents' states over time. Given a sufficient number of such features we show how to accurately predict the end results without fully performing the simulations. Our experiments with traffic simulations confirmed that our approach achieved better accuracies than existing simulation metamodeling approaches that only use the inputs and outputs of the simulations. Our results imply that one can quickly evaluate all scenarios by performing full simulations on only a fraction of them, and partial simulations on the rest.
An interleaved hop-by-hop authentication scheme for filtering of injected false data in sensor networks (2004)

Sensor networks are often deployed in unattended environments, thus leaving these networks vulnerable to false data injection attacks in which an adversary injects false data into the network with the goal of deceiving the base station or depleting the resources of the relaying nodes. Standard authentication mechanisms cannot prevent this attack if the adversary has compromised one or a small number of sensor nodes. In this paper, we present an interleaved hop-by-hop authentication scheme that guarantees that the base station will detect any injected false data packets when no more than a certain number t nodes are compromised. Further, our scheme provides an upper bound B for the number of hops that a false data packet could be forwarded before it is detected and dropped, given that there are up to t colluding compromised nodes. We show that in the worst case B is O(t/sup 2/). Through performance analysis, we show that our scheme is efficient with respect to the security it provides, and it also allows a tradeoff between security and performance.
Design, Synthesis, and Biological Evaluation of C<sup>9</sup>- and C<sup>2</sup>-Substituted Pyrazolo[4,3-<i>e</i>]-1,2,4-triazolo[1,5-<i>c</i>]pyrimidines as New A<sub>2A</sub>and A<sub>3</sub>Adenosine Receptors Antagonists (2003)

In the past few years, our group has been involved in the development of A(2A) and A(3) adenosine receptor antagonists which led to the synthesis of SCH58261 (5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine, 61), potent and very selective at the A(2A) receptor subtype, and N(8)-substituted-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines-N(5)-urea or amide (MRE series, b), very selective at the human A(3) adenosine receptor subtype. We now describe a large series of C(9)- and C(2)-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines to represent an extension of structure-activity relationship work on this class of tricyclic compounds. The introduction of a substituent at 9 position of the tricyclic antagonistic structure led to retention of receptor affinity but a loss of selectivity in respect to the lead compounds b, N(8)-substituted-pirazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines-N(5)-urea or -amide. The substitution of the furanyl moiety of compound 61, necessary for receptor binding, with a phenyl or a substituted aromatic ring (compounds 5a-d, 6-8), caused a complete loss of the affinity at all the adenosine receptor subtypes, demonstrating that the furanyl ring is a necessary structural element to guarantee interaction with the adenosine receptor surface. The introduction of an ethoxy group at the ortho position of the aromatic ring to mimic the oxygen of the furan (compound 5c, 5-amino-7-(2-phenylethyl)-2-(2-ethoxyphenyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) did not enhance affinity. The introduction of the cycloaminomethyl function by Mannich reaction at the 5' position of the furanyl ring of 61 and the C(9)-substituted compound 41 (5-amino-8-methyl-9-methylsulfanyl-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) resulted in complete water solubility but a loss of receptor affinity. We can conclude that modifications or substitutions at the furanyl ring are not allowed and the introduction of a substituent at the 9-position of the core pyrazolo-triazolo-pyrimidine structure caused a severe loss of selectivity, probably due to an increased steric hindrance of the radical introduced.
Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis (2004)

Tumor metastasis-the spreading of primary tumor cells to distal organs - is the major cause of death of cancer patients. The metastatic process consists of four distinct steps, invasion, intravasation, extravasation, and metastatic growth, and primary tumor cells need to acquire different genetic characteristics to accomplish each step. The main players during the metastatic process remain, however, largely unknown. A recent report in Cell by Robert Weinberg's group (Yang et al., Cell 2004;117:927-39) adds the transcription factor Twist to the list of metastatis regulators. Suppression of Twist expression in tumor cells inhibits the metastatic potential, whereas its overexpression induces an epithelial-mesenchymal transition (EMT) in epithelial cells. This study provides direct evidence that EMT may be an essential process during metastasis and should appropriately stimulate further investigations of EMT in many laboratories.
Dual window method for processing spectroscopic optical coherence tomography signals with high spectral and spatial resolution (2009)

The generation of spectroscopic optical coherence tomography (SOCT) signals suffers from an inherent trade off between spatial and spectral resolution. Here, we present a dual window (DW) method that uses two Gaussian windows to simultaneously obtain high spectral and spatial resolution. We show that the DW method probes the Winger time-frequency distribution (TFD) with two orthogonal windows set by the standard deviation of the Gaussian windows used for processing. We also show that in the limit of an infinitesimally narrow window, combined with a large window, this method is equivalent to the Kirkwood & Richaczek TFD and, if the real part is taken, it is equivalent to the Margenau & Hill (MH) TFD. We demonstrate the effectiveness of the method by simulating a signal with four components separated in depth or center frequency. Six TFD are compared: the ideal, the Wigner, the MH, narrow window short time Fourier transform (STFT), wide window STFT, and the DW. The results show that the DW method contains features of the Wigner TFD, and that it contains the highest spatial and spectral resolution that is free of artifacts. This method can enable powerful applications, including accurate acquisition of the spectral information for cancer diagnosis.
EFFECT OF IRRADIATION AND DIELECTRIC HEATING ON SOYBEAN ULTRASTRUCTURE, TRYPSIN INHIBITOR, AND LIPOXYGENASE ACTIVITIES (1991)

Scanning electron microscopy ( SEM) was used to observe the protein bodies of soybeans after irradiation (0 - 10 kGy dose range) , dielectric heating and storage . Microbiological changes , lip oxygenase and trypsin inhibit or activities and biological value were also studied after different treatments and storaee . There were no differences in the ultrastructure of control and irradiated ( 3, 6 and 10 kGy) soybeans immediately after irradiation . The effect of storage depended on whether whole or milled soybeans had been stored . There was no direct effect of dielectric he ating on soybeans ultrastruc ture , however , during storage it changed the same way as the milled and irradiated soybean . Irradiation reduced the number of microbes , but had no effect on the biological values or the activities of trypsin inhibitor and lipoxygenase (0- 10 kGy) . Dielectric heating had no effect on microbes , but inactivated the trypsin inhibitor and lipoxygenase and increased the biological values of the soybeans .
Depressive Signs and Symptoms in Schizophrenia (1998)

Depressive signs and symptoms in schizophrenia are responsive to treatment. The pleotrophic pharmacological features of olanzapine, through 1 or more non-D2-mediated pathways, likely contribute to its superior treatment effect. Better control of the mood disorders accompanying schizophrenia holds the possibility for improved patient outcomes.