gebhart/patrepeval huggingface dataset:
Weakly Supervised Learning for Fake News Detection on Twitter (2018)

The problem of automatic detection of fake news in social media, e.g., on Twitter, has recently drawn some attention. Although, from a technical perspective, it can be regarded as a straight-forward, binary classification problem, the major challenge is the collection of large enough training corpora, since manual annotation of tweets as fake or non-fake news is an expensive and tedious endeavor. In this paper, we discuss a weakly supervised approach, which automatically collects a large-scale, but very noisy training dataset comprising hundreds of thousands of tweets. During collection, we automatically label tweets by their source, i.e., trustworthy or untrustworthy source, and train a classifier on this dataset. We then use that classifier for a different classification target, i.e., the classification of fake and non-fake tweets. Although the labels are not accurate according to the new classification target (not all tweets by an untrustworthy source need to be fake news, and vice versa), we show that despite this unclean inaccurate dataset, it is possible to detect fake news with an F1 score of up to 0.9.
Printing the metal and contact layers for the 32- and 22-nm node: comparing positive and negative tone development process (2010)

A strong demand exists for techniques that can further extend the application of ArF immersion lithography. Besides techniques like litho-friendly design, dual exposure or patterning schemes, customized illumination modes, also alternative processing schemes are viable candidates to reach this goal. One of the most promising alternative process flows uses image reversal by means of a negative tone development (NTD) step with a FUJIFILM solvent-based developer. Traditionally, the printing of contacts and trenches is done by using a dark field mask in combination with positive tone resist and positive tone development. With NTD, the same features can be printed in positive resist using a light field mask, and consequently with a much better image contrast. In this paper, we present an overview of applications for the NTD technique, both for trench and contact patterning, comparing the NTD performance to that of the traditional positive tone development (PTD). This experimental work was performed on an ASML Twinscan XT:1900i scanner at 1.35 NA, and targets the contact/metal layers of the 32 & 22 nm node. For contact hole printing, we consider both single and dual exposure schemes for regular arrays and 2D patterns. For trench printing, we compare the NTD and PTD performance for one-dimensional patterns, line ends and twodimensional structures. We also assess the etch capability and CDU performance of the NTD process. This experimental study proves the added value of the NTD scheme. For contacts and trenches, it allows achieving a broader pitch range and/or smaller litho targets, which makes this process flow attractive for the most advanced lithography applications, including double patterning.
Automatic change detection in lane-level road networks using GPS trajectories (2017)

Lane-level road network updating is crucial for urban traffic applications that use geographic information systems contributing to, for example, intelligent driving, route planning and traffic control. Researchers have developed various algorithms to update road networks using sensor data, such as high-definition images or GPS data; however, approaches that involve change detection for road networks at lane level using GPS data are less common. This paper presents a novel method for automatic change detection of lane-level road networks based on GPS trajectories of vehicles. The proposed method includes two steps: map matching at lane level and lane-level change recognition. To integrate the most up-to-date GPS data with a lane-level road network, this research uses a fuzzy logic road network matching method. The proposed map-matching method starts with a confirmation of candidate lane-level road segments that use error ellipses derived from the GPS data, and then computes the membership degree between GPS data and candidate lane-level segments. The GPS trajectory data is classified into successful or unsuccessful matches using a set of defuzzification rules. Any topological and geometrical changes to road networks are detected by analysing the two kinds of matching results and comparing their relationships with the original road network. Change detection results for road networks in Wuhan, China using collected GPS trajectories show that these methods can be successfully applied to detect lane-level road changes including added lanes, closed lanes and lane-changing and turning rules, while achieving a robust detection precision of above 80%.
Enzymatic Hydrolysis of Flavonoids and Pectic Oligosaccharides from Bergamot (<i>Citrus bergamia</i> Risso) Peel (2006)

Pectinolytic and cellulolytic enzymes (Pectinase 62L, Pectinase 690L, and Cellulase CO13P) were used to evaluate the solubilization of carbohydrates and low molecular weight flavonoids from bergamot peel, a major byproduct of the essential oil industry. The enzymes were characterized for main-chain and side-chain polysaccharide hydrolyzing activities and also against pure samples of various flavonoids previously identified in bergamot peel to determine various glycosidase activities. The addition of Pectinase 62L or 690L alone, or the combination of Pectinase 62L and Cellulase CO13P, was capable of solubilizing between 70 and 80% of the bergamot peel, and up to 90% of the flavonoid glycosides present were cleaved to their aglycones. Cellulase CO13P alone solubilized 62% of the peel but had no deglycosylating effect on the flavonoid glycosides. Over a 24-h time course, a rapid release of cell wall carbohydrates was observed after treatment with Pectinase 62L, with a concurrent gradual hydrolysis of the flavonoid glycosides. Size-exclusion chromatography of the solubilized extract showed that after 24-h incubation, the majority of the solubilized carbohydrates were present as monosaccharides with a smaller proportion of oligosaccharides.
Structural Evolution of Wormlike Micellar Fluids Formed by Erucyl Amidopropyl Betaine with Oil, Salts, and Surfactants (2016)

Solutions of extended, flexible cylindrical micelles, often known as wormlike micelles, have great potential as the base for viscoelastic complex fluids in oil recovery, drilling, and lubrication. Here, we study the morphology and nanostructural characteristics of a model wormlike micellar fluid formed from erucyl amidopropyl betaine (EAPB) in water as a function of a diverse range of additives relevant to complex fluid formulation. The wormlike micellar dispersions are extremely oleo-responsive, with even as little as 0.1% hydrocarbon oil causing a significant disruption of the network and a decrease in zero-shear viscosity of around 100-fold. Simple salts have little effect on the local structure of the wormlike micelles but result in the formation of fractal networks at larger length scales, whereas even tiny amounts of small organic species such as phenol can cause unexpected phase transitions. When forming mixtures with other surfactants, a vast array of self-assembled structures are formed, from spheres to ellipsoids, lamellae, and vesicles, offering the ultimate sensitivity in designing formulations with specific nanostructural characteristics.
BILE ACID DERIVATIVES (1960)

The potassium permanganate oxidation of 3α, 12α-diacetoxy-24,24-diphenyl-Δ 23 -cholene yielded a new compound which was identified as 3α,12α-diacetoxy-23-keto-24-hydroxy-24,24-diphenylcholane. The latter steroid, on reduction with sodium borohydride, produced two isomeric glycols which were subsequently dehydrated to provide the corresponding 23-keto-24,24-diphenyl derivative.
Modulation Techniques to Eliminate Leakage Currents in Transformerless Three-Phase Photovoltaic Systems (2009)

In some photovoltaic (PV) applications, it is possible to remove the transformer of a system in order to reduce losses, cost, and size. In transformerless systems, the PV module parasitic capacitance can introduce leakage currents in which the amplitude depends on the converter topology, on the pulsewidth modulation, and on the resonant circuit comprised by the system components. Based on the common-mode voltage model, modulation techniques are proposed to eliminate the leakage current in transformerless PV systems without requiring any modification on the converter and any additional hardware. The main drawback is that the proposed modulation technique for two-level inverters can only be used with 650-V dc link in the case of a 110-V (rms) grid phase voltage. Comparisons among the modulation techniques are discussed, and it is proven that the proposed modulation for two- and three-level inverters presents the best results. To validate the models used in the simulations, an experimental three-phase inverter is used.
Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by<sup>18</sup>F-FDG Small-Animal PET (2007)

CE-355621 is an efficacious novel antineoplastic chemotherapeutic agent that inhibits (18)F-FDG accumulation earlier than tumor volume changes in a mouse xenograft model. These results support the use of (18)F-FDG PET to assess early tumor response for CE-355621.
Comparison of simultaneous variations of the ionospheric total electron content and geomagnetic field associated with strong earthquakes (2001)

Abstract. In this paper, perturbations of the ionospheric Total Electron Content (TEC) are compared with geomagnetic oscillations. Comparison is made for a few selected periods, some during earthquakes in California and Japan and others at quiet periods in Israel and California. Anomalies in TEC were extracted using Global Positioning System (GPS) observations collected by GIL (GPS in Israel) and the California permanent GPS networks. Geomagnetic data were collected in some regions where geomagnetic observatories and the GPS network overlaps. Sensitivity of the GPS method and basic wave characteristics of the ionospheric TEC perturbations are discussed. We study temporal variations of ionospheric TEC structures with highest reasonable spatial resolution around 50 km. Our results show no detectable TEC disturbances caused by right-lateral strike-slip earthquakes with minor vertical displacement. However, geomagnetic observations obtained at two observatories located in the epicenter zone of a strong dip-slip earthquake (Kyuchu, M = 6.2, 26 March 1997) revealed geomagnetic disturbances occurred 6–7 h before the earthquake.
Therapy with amineptine, a dopamine reuptake inhibitor, in patients with major depression. (1997)

The original tricyclic antidepressant drugs are consistently underused in major depression because of side effects, delayed onset of action, and potential for overdose. In an open study of 6 weeks' duration, we studied the efficacy and acceptability of amineptine, a dopamine reuptake inhibitor, at fixed dose of 200 mg per day in 50 patients with major depression.Intention-to-treat analysis showed a patient response rate of 64% (95% CI 77-50) in HDRS, 62% (95% CI 75-48) in MADRS, 46% (95% CI 59-32) in ZUNG scale, 52% (95% CI 66-38) in Social Activity scale, and 26% ("95% CI 38-14) in CGI-severity of illness after 7 days treatment. Response in CGI-global improvement was 38% (95% CI 51-25), and in CGI-efficacy index 48% (95% CI 62-34) after 14 days of treatment. With continued therapy, only CGI-severity of illness showed a significant increase in response rate after 42 days. The treatment effect of amineptine was reflected in a significant and progressive improvement in all depression, social activity, and CGI rating scale scores throughout the study period. Somatic symptoms and side effects assessed by AMDP-5 showed significant improvement at each assessment.The clinically useful response in depression which occurred by the first week of treatment, favourable side effect profile, and the convenience of a fixed dose could make amineptine a suitable first line alternative for the treatment of major depression.
Bone mesenchymal stem cells attenuate resiniferatoxin-induced neuralgia via inhibiting TRPA1-PKCδ-P38/MAPK-p-P65 pathway in mice (2021)

Treatment of neuropathic pain (NP) resulting from nerve injury is one of the most complicated and challenging in modern practice. Pharmacological treatments for NP are not fully effectively and novel approaches are requisite. Recently, transplantation of bone mesenchymal stem cells (BMSCs) has represented a promising approach for pain relief and neural repair, but how it produces beneficial effects on resiniferatoxin (RTX) induced nerve injury is still unclear. Here, we identified the BMSCs' analgesic effects and their potential mechanisms of microglial cells activation on RTX induced neuralgia. Immunostaining, biochemical studies demonstrated that microglia rather than astrocyte cells activation involved in RTX induced mechanical hyperalgesia, whereas the GFP-labeled BMSCs alleviated this mechanical hyperalgesia. Moreover, pain-related TRPA1, PKCδ, CaMKIIɑ (Calcium/calmodulin dependent protein kinase II), P38/MAPK (mitogen-activated protein kinase), p-P65 activation and expression in the spinal cord were significantly inhibited after BMSC administration. In addition, BMSCs treated RTX mice displayed a lower density of mushroom dendritic spines. Our research suggested that activation of PKCδ-CaMKIIɑ-P38/MAPK-p-P65 pathway and mushroom dendritic spines abnormal increase in the spinal cord is the main mechanism of RTX induced neuropathic pain, and transplant of BMSCs to the damaged nerve may offer promising approach for neuropathic pain.
<title>Adaptive self-quantization of wavelet subtrees: a wavelet-based theory of fractal image compression</title> (1995)

Fractal image compression was one of the earliest compression schemes to take advantage of image redundancy in scale. The theory of iterated function systems motivates a broad class of fractal schemes but does not give much guidance for implementation. Fractal compression schemes do not fit into the standard transform coder paradigm and have proven difficult to analyze. We introduce a wavelet-based framework for analyzing fractal block coders which simplifies these schemes considerably. Using this framework we find that fractal block coders are Haar wavelet subtree quantization schemes, and we thereby place fractal schemes in the context of conventional transform coders. We show that the central mechanism of fractal schemes is an extrapolation of fine-scale Haar wavelet coefficients from coarse-scale coefficients. We use this insight to derive a wavelet-based analog of fractal compression, the self-quantization of subtrees (SQS) scheme. We obtain a simple SQS decoder convergence proof and a fast SQS decoding algorithm which simplify and generalize existing fractal compression results. We describe an adaptive SQS compression scheme which outperforms the best fractal schemes in the literature by roughly 1 dB in PSNR across a broad range of compression ratios and which has performance comparable to some of the best conventional wavelet subtree quantization schemes.
LIMITATIONS OF A NEW FREE THYROXINE ASSAY (AMERLEX® FREE T4) (1981)

We have assessed a new method of free T4 measurement (Amerlex) which uses a novel unidentified T4-labelled analogue, said to be unreactive with T4 binding proteins in serum, together with an antibody that binds both analogue and T4. Free T4 is assessed by competition with analogue for antibody binding-sites. The test method has been compared with free T4 measured by equilibrium dialysis and with a technique using an immobilized T4 antibody. All methods gave the expected free T4 levels in normal, hyperthyroid and hypothyroid subjects and normal free T4 levels with high or low levels of T4 binding globulin. However, in autosomal dominant familial euthyroid T4-excess, where T4 is abnormally bound to albumin, the test method gave apparent high free T4 levels suggestive of hyperthyroidism. In a selected group of severely-ill euthyroid patients the new method gave apparent low free T4 levels. In view of these discrepancies, binding of labelled analogue was evaluated by dextran-charcoal separation of 4 degraees C. Familial euthyroid T4-excess sera showed greater analogue binding and samples with low prealbumin concentration showed less binding than did normal sera. Despite its validity with variations in TBG, it appears that Amerlex Free T4 is influenced by lower-affinity, high-capacity T4 binding sites in serum, so that apparent free T4 concentration may vary with changes in the concentration of such sites.
Rapid HPLC Analysis of Dietary Phytoestrogens from Legumes and from Human Urine (1995)

Due to growing evidence suggesting that phytoestrogens might protect against various cancers, particularly against breast and prostate cancer, it is important to measure the exposure of populations to these compounds by determining levels in food and in human tissue or body fluids to assess the possible cancer protective properties of these agents. Therefore, we developed a simple and fast procedure to extract and simultaneously hydrolyze phytoestrogens and their conjugates from food items, and present a fast and selective high-performance liquid chromatography (HPLC) method for precise determinations of the most common dietary phytoestrogens genistein, biochanin-A, daidzein, formononetin, and coumestrol using flavone as internal standard. For the first time HPLC was applied to measure these phytoestrogens and their most abundant metabolites equol and O-desmethyl-angolensin from human urine. The proposed methodology has been evaluated for losses due to thermal degradation during extraction and hydrolysis and due to sample handling during the entire work-up including solid phase extraction, and values are given for inter- and intra-assay variability. We present isoflavonoid levels of most common peas and beans used in "western" and "eastern" diets and compare isoflavonoid and coumestrol levels of raw, canned, and cooked foods which can be used in future epidemiological studies. We also determined human urinary levels with our methodology comparing values before and after soybean intake.
Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity. (1986)

Human factor VIII was isolated from commercial factor VIII concentrates and found to consist of multiple polypeptides with molecular weights ranging from 80 000 to 210 000. Immunological and amino acid sequence data identified these polypeptides as subunits of factor VIII. N-Terminal amino acid sequence analysis determined that the Mr 210 000 and 80 000 proteins are derived from the N- and C-terminal portions of factor VIII, respectively; Mr 90 000-180 000 polypeptides are derived from the Mr 210 000 polypeptide by C-terminal cleavages. Treatment of purified factor VIII with thrombin resulted in proteolysis of Mr 80 000-210 000 proteins and the generation of polypeptides of Mr 73 000, 50 000, and 43 000. Maximum coagulant activity of thrombin-activated factor VIII was correlated with the generation of these polypeptides. The proteolysis as well as activation of factor VIII by thrombin was found to be markedly dependent on CaCl2 concentration. Proteolysis of factor VIII with activated protein C (APC) resulted in degradation of the Mr 90 000-210 000 proteins with the generation of an Mr 45 000 fragment. This cleavage correlated with inactivation of factor VIII by APC. The Mr 80 000 protein was not degraded by APC. Factor Xa cleaved the Mr 80 000-210 000 factor VIII proteins, resulting in the generation of fragments of Mr 73 000, 67 000, 50 000, 45 000, and 43 000. Factor Xa was found to initially activate and subsequently inactivate factor VIII.(ABSTRACT TRUNCATED AT 250 WORDS)
Three‐Dimensional Echocardiography in Evaluation of Left Ventricular Indices (2012)

Accurate determination of left ventricular mass, volume, ejection fraction, and wall motion is important for clinical decision making. Currently, M-mode and two-dimensional echocardiography (2DE) have been routinely used for this purpose. Although these 1D or 2D modalities provide excellent diagnostic and prognostic information, they have a number of technical limitations including the time required to perform the procedure and operator-dependent image acquisitions. In addition, they are inherently limited by geometric assumption of three-dimensional (3D) left ventricular structures based on 2D slices. With the improvement in transducer technology and software development, 3D echocardiography (3DE) has become widely available. Left ventricular quantitation by 3DE has been demonstrated to be accurate by multiple studies that compared 3DE with reference techniques. In addition, 3DE measurements were found to be more reproducible and less variable than 2DE. Real time 3DE imaging has potential advantages in stress echocardiography including rapid acquisition, unlimited number of planes, avoidance of foreshortening, and precise segment matching. This is a major step forward in our diagnostic armamentarium for the evaluation of ischemia. In this review, we summarized the current evidence of 3DE for left ventricular evaluation.
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8 (2001)

The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonist, whereas vMIP-II acted as a low-affinity antagonist on the murine CCR8 as well as the human CCR8. MC148 was found to bind and block responses through the human CCR8 with high affinity, but surprisingly MC148 was unable to bind and block responses through the murine CCR8. Because MC148 is the only high-affinity antagonist known to target and be selective for CCR8, MC148 is a valuable tool to decipher the role played by CCR8 in the immune system. This study shows that MC148 could not be used in murine inflammatory models; however, it will be interesting to see whether it can be used in other animal models to delineate the role played by CCR8.
A Facile One‐Pot Access to Dibenzo[<i>b</i>,<i>e</i>]oxepines by a Lewis Acid Catalysed Tandem Reaction (2011)

Abstract Dibenzo[ b , e ]oxepine derivatives have been constructed efficiently by one‐pot tandem carbon–carbon bond formation reactions. First, 2‐(3,5‐dimethoxybenzyloxy)benzaldehydes were treated with various nucleophiles under I 2 catalysis and then 1‐(3,5‐dimethoxybenzyloxy)‐3,5‐dimethoxybenzene was treated with several aromatic as well as heteroaromatic aldehydes under BF 3 · Et 2 O catalytic conditions to provide dibenzo[ b , e ]oxepines in good yields.