gebhart/patrepeval huggingface dataset:
Low Flow Rate Sharp Cut Impactors for Indoor Air Sampling: Design and Calibration (1987)

Two single round nozzle impactors have been developed for use in Harvard’s indoor air pollution health study. Both impactors operate at flow rates of 4 L/m and are nearly identical, differing only in their cut sizes of 2.5 μm and 10 μm aerodynamic diameters. Two identical cascaded stages of the same cut size are used to obtain sharp cut-off characteristics. The particles are deposited on impaction plates made of oil impregnated, porous material to reduce particle bounce and are discarded. Only the particles collected on the afterfilter are analyzed. Special care has been taken to collect the particles uniformly on the afterfilter to aid in particle analysis. The jmpactors were calibrated with a vibrating orifice monodisperse aerosol generator. However, due to the sharp cut of the impactors, doublets and triplets in the calibration aerosols, even in small quantities, gave erroneous calibration curves. Therefore, the number of doublets and triplets in the challenging aerosols were measured and appropriate corrections made to the calibration curves.
Doping of polyaniline via pseudoprotonation by an ionic salt (1995)

Polyaniline can be converted into a conducting form by either protonation of the imine site or oxidative doping at the amine site. Here, a new class of dopant is reported, ionic salts. An ionic‐salt‐doped polyaniline is obtained by mixing the emeraldine base of polyaniline and solutions of, for example, LiClO 4 , LiBF 4 , or Zn(ClO 4 ) 2 in 1‐methyl‐2‐pyrrolidone, and then casting the solution to form films. Materials synthesis, film production, and the demonstration that the material is intrinsically, rather then ionically, conducting are discussed.
Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis (2016)

Porphyromonas gingivalis is a keystone pathogen of periodontitis. One of its bacterial characteristics is the ability to invade various host cells, including nonphagocytic epithelial cells and fibroblasts, which is known to facilitate P. gingivalis adaptation and survival in the gingival environment. In this study, we investigated two small compounds, Alop1 and dynasore, for their role in inhibition of P. gingivalis invasion. Using confocal microscopy, we showed that these two compounds significantly reduced invasion of P. gingivalis and its outer membrane vesicles into human oral keratinocytes in a dose-dependent manner. The inhibitory effects of dynasore, a dynamin inhibitor, on the bacterial entry is consistent with the notion that P. gingivalis invasion is mediated by a clathrin-mediated endocytic machinery. We also observed that microtubule arrangement, but not actin, was altered in the host cells treated with Alop1 or dynasore, suggesting an involvement of microtubule in this inhibitory activity. This work provides an opportunity to develop compounds against P. gingivalis infection.
The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity (1999)

Rho-kinase is implicated in the phosphorylation of myosin light chain downstream of Rho, which is thought to induce smooth muscle contraction and stress fiber formation in non-muscle cells. Here, we examined the mode of action of inhibitors of Rho-kinase. The chemical compounds such as HA1077 and Y-32885 inhibited not only the Rho-kinase activity but also the activity of protein kinase N, one of the targets of Rho, but had less of an effect on the activity of myotonic dystrophy kinase-related Cdc42-binding kinase beta (MRCKbeta). The COOH-terminal portion of Rho-kinase containing Rho-binding (RB) and pleckstrin homology (PH) domains (RB/PH (TT)), in which point mutations were introduced to abolish the Rho binding activity, interacted with Rho-kinase and thereby inhibited the Rho-kinase activity, whereas RB/PH (TT) had no effect on the activity of protein kinase N or MRCKbeta, suggesting that the COOH-terminal region of Rho-kinase is a possible negative regulatory region of Rho-kinase. The expression of RB/PH (TT) specifically blocked the stress fiber and focal adhesion formation induced by the active form of Rho or Rho-kinase in NIH 3T3 cells, but not that induced by the active form of MRCKbeta or myosin light chain. Thus, RB/PH (TT) appears to specifically inhibit Rho-kinase in vivo.
Synthesis of Ethylene and Propylene Sulfides (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Ethylene and Propylene SulfidesJOHN A. DURDEN Jr., HARRY A. STANSBURY Jr., and WILLIAM H. CATLETTECite this: J. Org. Chem. 1961, 26, 3, 836–839Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/jo01062a046https://doi.org/10.1021/jo01062a046research-articleACS PublicationsRequest reuse permissionsArticle Views179Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Quasi-Uniformity Condition and Three-Dimensional Geometry Representation as it Applies to the Reproducing Kernel Element Method (2009)

The Reproducing Kernel Element Method (RKEM) is a hybrid between finite elements and meshfree methods that provides shape functions of arbitrary order and continuity yet retains the Kronecker-delta property. To achieve these properties, the underlying mesh must meet certain regularity constraints, unique to RKEM. The aim of this dissertation is to develop a precise definition of these constraints, and a general algorithm for assessing a mesh is developed. This check is a critical step in the use of RKEM in any application.\nThe general checking algorithm is made more specific to apply to two-dimensional triangular meshes with circular supports and to three-dimensional tetrahedral meshes with spherical supports. The checking algorithm features the output of the uncovered regions that are used to develop a mesh-mending technique for fixing offending meshes. The specific check is used in conjunction with standard quality meshing techniques to produce meshes suitable for use with RKEM.\nThe RKEM quasi-uniformity definitions enable the use of RKEM in solving Galerkin weak forms as well as in general interpolation applications, such as the representation of geometries. A procedure for determining a RKEM representation of discrete point sets is presented with results for surfaces in three-dimensions. This capability is important to the analysis of geometries such as patient-specific organs or other biological objects.
Combining Feature Kernels For Semantic Music Retrieval. (2008)

[TODO] Add abstract here.
Observations of Barnacle Detachment from Silicones using High-Speed Video (2005)

ABSTRACT The detachment of barnacles (under shear and tensile loads) from silicone was investigated with the aid of high-speed digital video recording. A handheld probe was used to apply loads to the shells of barnacles attached to three clear silicone-elastomer coatings of known thickness applied to glass plates. The tests were performed in the laboratory in air and underwater. Representative data are presented as a qualitative description of separation at the barnacle adhesive–silicone interface. Detailed examination of adhesive separation during detachment provided new insight into the nature of a marine biological adhesive on a low modulus, artificial surface. The visible response of the barnacle adhesive on silicone under external shear and tensile loading was suggestive of the viscous fingering seen in Saffman–Taylor instabilities. Complex branching separation occurred in rapid progression, usually within 100 ms. The results suggest that the barnacle adhesive exhibits rheological responses of a viscous material at the interface with silicone surfaces. Additional experiments with time-lapse photography demonstrated that the adhesive was stable underwater but became dehydrated or coalesced when exposed directly to air. A simple model of the adhesive system of a barnacle in contact with silicone based upon Balanus eburneus is proposed to assist in the development of a more complete understanding of barnacle adhesion.
THE SAND-BOX (1993)

High performance concrete (HPC) is being increasingly used for many applications, and it is necessry to have a reliable and easy method of testing cylinders, suitable for any small laboratory, with minimal initial investment. Various methods for doing this are discussed. The lapping process remains the best for results but it entails expensive investment. Methods based on the use of bonded caps are questionable. As the strength of confined sand seems to have no limits, the sand-box method is theoretically more reliable. The practical suitability of the sandbox process has been demonstrated in round-robin tests.
Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. (1991)

Splenic and bone marrow cells from normal mice, and from mice that have been polyclonally activated by injection of anti-IgD antibody, contain cells that produce interleukin 4 (IL-4) in response to crosslinkage of Fc epsilon receptors (Fc epsilon R) or Fc gamma R or to ionomycin. Isolated Fc epsilon R+ cells have recently been shown to contain all of the IL-4-producing capacity of the nonlymphoid compartment of spleen and bone marrow. Here, purified Fc epsilon R+ cells are shown to be enriched in cells that contain histamine and express alcian blue-positive cytoplasmic granules. By electron microscopy, the vast majority of cytoplasmic granule-containing cells are basophils; they constitute approximately 25% and approximately 50%, respectively, of Fc epsilon R+ spleen and bone marrow cells from anti-IgD-injected mice. The Fc epsilon R- populations contain cells that form colonies typical of mast cells. The Fc epsilon R+ populations also contain cells that, upon culture with IL-3, form colonies of alcian blue-positive cells, but (in contrast to colonies derived from Fc epsilon R- populations) the colonies are small, and all the cells die within 2-3 weeks. The Fc epsilon R+ cells synthesize histamine during a 60-hr culture with IL-3, while the Fc epsilon R- cells do not. These results indicate that IL-4-producing Fc epsilon R+ cells are highly enriched in basophils.
Improvement on Live Migration of Virtual Machine by Limiting the Activity of CPU (2017)

In the process of virtual machine live migration, the use of pre-copy technique can effectively reduce the downtime. However, when the generation rate of dirty pages is higher than the transmission rate, the dirty pages will accumulate, resulting in the failure of live migration. To avoid the live migration get failed, this paper proposes a method that can ensure the success of live migration by reducing the activity of CPU and adding a mandatory stop condition. The experimental results show that the total time of live migration and the transmission data size are decreased by the proposed method.
Importance of Monitoring the Circulating Blood Volume in Patients with Cerebral Vasospasm after Subarachnoid Hemorrhage (1981)

We used the isotope dilution technique to monitor circulating blood volume (CBV) in three patients with ruptured cerebral aneurysms who developed pre- or postoperative ischemic symptoms that responded well to intravascular volume expansion therapy with blood transfusion and plasma expanders. In the first and second cases, predeterioration CBVs were obtained. Both of these patients showed hypovolemia and a decreased red blood cell volume at the time of neurological deterioration. A predeterioration CBV was not available for the third patient for comparison, but his red cell volume was also markedly decreased. Postrecovery CBVs were obtained in the second and third cases. Our data suggested that a depleted red blood cell volume was more responsible for neurological deterioration than was a lowered plasma volume. To prevent the occurrence of hypovolemia and anemia in aneurysm patients, we should monitor CBV not only at the time of neurological deterioration, but also at the time of admission and during the immediate postoperative period.
Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness (2014)

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 has resulted in severe human respiratory disease with high death rates. Their zoonotic origins highlight the likelihood of reemergence or further evolution into novel human coronavirus pathogens. Broadly neutralizing antibodies (nAbs) that prevent infection of related viruses represent an important immunostrategy for combating coronavirus infections; however, for this strategy to succeed, it is essential to uncover nAb-mediated escape pathways and to pioneer strategies that prevent escape. Here, we used SARS-CoV as a research model and examined the escape pathways of broad nAbs that target the receptor binding domain (RBD) of the virus. We found that neither single nAbs nor two nAbs in combination blocked escape. Our results suggest that targeting conserved regions with less plasticity and more structural constraint rather than the SARS-CoV RBD-like region(s) should have broader utility for antibody-based immunotherapy.
Efficient Data Race Detection for C/C++ Programs Using Dynamic Granularity (2014)

To detect races precisely without false alarms, vector clock based race detectors can be applied if the overhead in time and space can be contained. This is indeed the case for the applications developed in object-oriented programming language where objects can be used as detection units. On the other hand, embedded applications, often written in C/C++, necessitate the use of fine-grained detection approaches that lead to significant execution overhead. In this paper, we present a dynamic granularity algorithm for vector clock based data race detectors. The algorithm exploits the fact that neigh boring memory locations tend to be accessed together and can share the same vector clock archiving dynamic granularity of detection. The algorithm is implemented on top of Fast Track and uses Intel PIN tool for dynamic binary instrumentation. Experimental results on benchmarks show that, on average, the race detection tool using the dynamic granularity algorithm is 43% faster than the Fast Track with byte granularity and is with 60% less memory usage. Comparison with existing industrial tools, Val grind DRD and Intel Inspector XE, also suggests that the proposed dynamic granularity approach is very viable.
Neurotrophin p75 Receptor Is Involved in Neuronal Damage by Prion Peptide-(106–126) (2001)

In this work we have investigated the molecular basis of the neuronal damage induced by the prion peptide by searching for a surface receptor whose activation could be the first step of a cascade of events responsible for cell death. By using a human neuroblastoma cell line lacking all the neurotrophin receptors and derived clones expressing the full-length or truncated forms of the low affinity neurotrophin receptor (p75(NTR)), we have been able to demonstrate that the neuronal death induced by the prion protein fragment PrP-(106-126) is an active process mediated by a) the binding of the peptide to the extracellular region of p75(NTR), b) the signaling function of the intracytoplasmic region of the receptor, and c) the activation of caspase-8 and the production of oxidant species.
Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-8 (2005)

Caspase-8 is an essential component of death receptor-mediated apoptosis. Along with Fas-associated death domain protein, it is also essential for T cell proliferation in response to antigenic or mitogenic stimuli. To determine whether caspase-8 is also required for B cell proliferation, we generated mice with a B cell-specific Casp8 deficiency. Unlike T cells, caspase-8 was not required for Ag receptor-driven proliferation or Ab formation. Rather, Casp8-deficient B cells failed to proliferate in response to dsRNA and LPS, ligands for TLR3 and TLR4, respectively, but responded normally to the TLR9 agonist CpG DNA. Similarly, Ab production to trinitrophenol-LPS was selectively reduced in B cell-specific Casp8-deficient mice. The activation of NF-kappaB or IFN regulatory factor 3 was found to be unaffected by the loss of caspase-8, implicating it in a novel pathway important for some forms of innate immunity mediated by B cells.
Characterization of T cell surface glycoproteins T1 and T3 present on all human peripheral T lymphocytes and functionally mature thymocytes (1981)

The monoclonal antibodies, anti-T1 and anti-T3, both react with all human peripheral thymus-derived lymphocytes and with 10% of thymocytes; each, however, recognizes different cell surface structures. It was determined that the target antigen of anti-T is a 69 000 molecular weight cell surface glycoprotein and that the T3 antigen is a 19 000 mol. wt. glycoprotein.
Design of prismatic quadruped walking vehicle TITAN VI (1991)

A quadruped walking vehicle TITAN VI having a new leg mechanism is designed and manufactured. Objectives of design of TITAN VI are to walk on an ordinary staircase of 30 to 40 degrees, to constitute an active platform which assists manipulation in the stationary condition, and to walk at a high speed by using dynamic walk. The new mechanisms introduced in TITAN VI are, (1) prismatic joint leg mechanism which does not interfere with the steps of a staircase, and which performs a cylindrical coordinates motion with good energy efficiency, (2) an articulated body structure having node which copes with a steep staircase, (3) a vertical foot driving system having a dual mode transmission mechanism and the like. The detail of these mechanisms are discussed. The effectiveness of these considerations are verified by the walking experiment using the trial-manufactured TITAN VI.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Ultrasound for revision hip arthroplasty (1993)

Log in or Register Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Register Login HomeCurrent IssuePrevious Issues Current Orthopaedic PracticeCurrent Opinion in Orthopaedics (1999-2007)Clinical Orthopaedics and Related Research (1976-2007) Published Ahead-of-PrintCOP eNewsMy CollectionsJournal Info About the JournalEditorial BoardInformation for AuthorsAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling. (1992)

The recycling of synaptic vesicles in nerve terminals is thought to involve clathrin-coated vesicles. However, the properties of nerve terminal coated vesicles have not been characterized. Starting from a preparation of purified nerve terminals obtained from rat brain, we isolated clathrin-coated vesicles by a series of differential and density gradient centrifugation steps. The enrichment of coated vesicles during fractionation was monitored by EM. The final fraction consisted of greater than 90% of coated vesicles, with only negligible contamination by synaptic vesicles. Control experiments revealed that the contribution by coated vesicles derived from the axo-dendritic region or from nonneuronal cells is minimal. The membrane composition of nerve terminal-derived coated vesicles was very similar to that of synaptic vesicles, containing the membrane proteins synaptophysin, synaptotagmin, p29, synaptobrevin and the 116-kD subunit of the vacuolar proton pump, in similar stoichiometric ratios. The small GTP-binding protein rab3A was absent, probably reflecting its dissociation from synaptic vesicles during endocytosis. Immunogold EM revealed that virtually all coated vesicles carried synaptic vesicle proteins, demonstrating that the contribution by coated vesicles derived from other membrane traffic pathways is negligible. Coated vesicles isolated from the whole brain exhibited a similar composition, most of them carrying synaptic vesicle proteins. This indicates that in nervous tissue, coated vesicles function predominantly in the synaptic vesicle pathway. Nerve terminal-derived coated vesicles contained AP-2 adaptor complexes, which is in agreement with their plasmalemmal origin. Furthermore, the neuron-specific coat proteins AP 180 and auxilin, as well as the alpha a1 and alpha c1-adaptins, were enriched in this fraction, suggesting a function for these coat proteins in synaptic vesicle recycling.
The program dependence graph in a software development environment (1984)

The internal program representation chosen for a software development environment plays a critical role in the nature of that environment. A form should facilitate implementation and contribute to the responsiveness of the environment to the user. The program dependence graph (PDG) may be a suitable internal form. It allows programs to be sliced in linear time for debugging and for use by language-directed editors. The slices obtained are more accurate than those obtained with existing methods because I/O is accounted for correctly and irrelevant statements on multi-statement lines are not displayed. The PDG may be interpreted in a data driven fashion or may have highly optimized (including vectorized) code produced from it. It is amenable to incremental data flow analysis, improving response time to the user in an interactive environment and facilitating debugging through data flow anomaly detection. It may also offer a good basis for software complexity metrics, adding to the completeness of an environment based on it.