gebhart/patrepeval huggingface dataset:
Surface Functionalization of Natural Rubber by UV‐Induced Thiol‐ene Chemistry (2016)

Summary Natural rubber (NR) surfaces with tailored physicochemical properties and spatially controlled surface topology were prepared by exploiting radical‐mediated thiol‐ene chemistry. Selected functional thiols were immobilized onto NR surfaces by the photo‐induced addition reaction across the unsaturated CC double bonds of the cis ‐1,4‐isoprene units. The modified elastomer surfaces are characterized by means of ATR FTIR spectroscopy to follow changes in the chemical surface composition, and by contact angle measurements to study changes in surface polarities. The results evidence the versatility of this photochemical functionalization route since different surface characteristics and surface reactivities were obtained, depending on the chemical nature of the attached thiol. In addition, the influence of the surface functionalization on bulk properties and surface morphology was determined by tensile tests and microscopic techniques, respectively. Results show that both tensile properties and surface morphology are not affected by the photochemical functionalization process. The immobilized thiols were further used as reactive anchor groups for a subsequent immobilization of inorganic silica particles, resulting in a well‐defined change in surface roughness and topology. Spatial control of surface properties was accomplished by photolithographic techniques that enabled a patterned immobilization of inorganic particles onto NR surfaces. Microscopic techniques revealed the selective coupling of the inorganic particles in the illuminated surface areas that were defined by high resolution and clear edges.
Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice (2017)

Recombinant adeno-associated virus (rAAV)-mediated gene delivery shows promise to transduce the pancreas, but safety/efficacy in a neoplastic context is not well established. To identify an ideal AAV serotype, route, and vector dose and assess safety, we have investigated the use of three AAV serotypes (6, 8, and 9) expressing GFP in a self-complementary (sc) AAV vector under an EF1α promoter (scAAV.GFP) following systemic or retrograde pancreatic intraductal delivery. Systemic delivery of scAAV9.GFP transduced the pancreas with high efficiency, but gene expression did not exceed >45% with the highest dose, 5 × 10<sup>12</sup> viral genomes (vg). Intraductal delivery of 1 × 10<sup>11</sup> vg scAAV6.GFP transduced acini, ductal cells, and islet cells with >50%, ∼48%, and >80% efficiency, respectively, and >80% pancreatic transduction was achieved with 5 × 10<sup>11</sup> vg. In a Kras<sup>G12D</sup>-driven pancreatic cancer mouse model, intraductal delivery of scAAV6.GFP targeted acini, epithelial, and stromal cells and exhibited persistent gene expression 5 months post-delivery. In normal mice, intraductal delivery induced a transient increase in serum amylase/lipase that resolved within a day of infusion with no sustained pancreatic inflammation or fibrosis. Similarly, in PDAC mice, intraductal delivery did not increase pancreatic intraepithelial neoplasia progression/fibrosis. Our study demonstrates that scAAV6 targets the pancreas/neoplasm efficiently and safely via retrograde pancreatic intraductal delivery.
Cadherin-6:: A New Prognostic Marker for Renal Cell Carcinoma (2004)

Cadherin-6, a new cell adhesion molecule of the cadherin family, is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. In our prospective analysis the pattern of cadherin-6 expression correlated with known prognostic factors of renal cell cancer on univariate and multivariate analysis. Our data suggest that cadherin-6 is a new prognostic factor for renal cancer.
Studies in Red Blood Cell Preservation - 1. Effect of the Other Formed Elements (1990)

The purpose of this study was to determine if the removal of most of the leukocytes and platelets would affect the in vitro characteristics of stored red blood cells (RBC). Fresh RBC concentrates prepared by removing platelet-rich plasma and filtration through Imugard IG 500 filters were compared with unmanipulated units after storage for up to 56 days. The filtered units were significantly better after 56 days storage for supernatant K^+ (p = 0.001), hemolysis (p = 0.05), total vesicle membrane protein shed (p = 0.03), and RBC morphology score (p = 0.04). These differences occurred even though ATP levels were well maintained in both groups. The measurements that did not differ significantly were pH, hematocrit, ATP, 2,3-DPG, glucose and supernatant Na^+. It is suggested that enzymes, leukotrienes, catecholamines and eicosanoids released by degenerating leukocytes and platelets may be inimical to RBC. Some may act as agonists on α-adrenergic and cholinergic muscarinic receptors present on RBC membranes.
3D smooth path planning for a UAV in cluttered natural environments (2008)

This paper presents a 3D path planing algorithm for an unmanned aerial vehicle (UAV) operating in cluttered natural environments. The algorithm satisfies the upper bounded curvature constraint and the continuous curvature requirement. In this work greater attention is placed on the computational complexity in comparison with other path-planning considerations. The rapidly-exploring random trees (RRTs) algorithm is used for the generation of collision free waypoints. The unnecessary waypoints are removed by a simple path pruning algorithm generating a piecewise linear path. Then a path smoothing algorithm utilizing cubic Bezier spiral curves to generate a continuous curvature path that satisfies the minimum radius of curvature constraint of UAV is implemented. The angle between two waypoints is the only information required for the generation of the continuous curvature path. The result shows that the suggested algorithm is simple and easy to implement compared with the Clothoids method.
The C-terminus of interferon gamma receptor beta chain (IFNγR2) has antiapoptotic activity as a bax inhibitor (2009)

Bax is a pro-apoptotic protein that mediates intrinsic cell-death signaling. Using a yeast-based functional screening approach, we identified interferon gamma receptor beta chain (IFNgammaR2) as a new Bax suppressor. IFNgammaR2 is a component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNgammaR1). Upon IFNgamma binding, a conformational change in the receptor complex occurs that activates the Jak2/STAT1 signaling cascade. We found that the C-terminal region (amino acids 296-337) of IFNgammaR2 (IFNgammaR2(296-337)) contains a novel Bax inhibitory domain. This portion does not contain the Jak2-binding domain; therefore, the antiapoptotic function of IFNgammaR2 is independent of JAK/STAT signaling. IFNgammaR2(296-337) rescued human cells from apoptosis induced by overexpression of Bax but not Bak. Overexpression of IFNgammaR2 (wild type and IFNgammaR2(296-337)) rescued cells from etoposide and staurosporine, which are known to induce Bax-mediated cell death. Interestingly, IFNgammaR2 inhibited apoptosis induced by the BH3-only protein Bim-EL, suggesting that IFNgammaR2 inhibits Bax activation through a BH3-only protein. Bax and IFNgammaR2 were co-immunoprecipitated from cell lysates prepared from HEK293 and DAMI cells. Furthermore, direct binding of purified recombinant proteins of Bax and IFNgammaR2 was also confirmed. Addition of recombinant Bcl-2 protein to cell lysates significantly reduced the interaction of IFNgammaR2 and Bax, suggesting that Bcl-2 and IFNgammaR2 bind a similar domain of Bax. We found that the C-terminal fragment (cytoplasmic domain) of IFNgammaR2 is expressed in human cancer cell lines of megakaryocytic cancer (DAMI), breast cancer (MDA-MD-468), and prostate cancer (PC3 cells). The presence of the C-terminal fragment of IFNgammaR2 may confer on cancer cells resistance to apoptotic stresses. Our discovery of the anti-Bax activity of the cytoplasmic domain of IFNgammaR2 may shed new light on the mechanism of how cell death is controlled by IFNgamma and Bax.
Probing the Working Memory System in Chronic Fatigue Syndrome: A Functional Magnetic Resonance Imaging Study Using the n-Back Task (2006)

These results suggest that patients with CFS show both quantitative and qualitative differences in activation of the working memory network compared with healthy control subjects. It remains to be determined whether these findings stay stable after successful treatment.
CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse (2018)

We recently established that hybrid insulin peptides (HIPs), formed in islet β-cells by fusion of insulin C-peptide fragments to peptides of chromogranin A or islet amyloid polypeptide, are ligands for diabetogenic CD4 T-cell clones. The goal of this study was to investigate whether HIP-reactive T cells were indicative of ongoing autoimmunity. MHC class II tetramers were used to investigate the presence, phenotype, and function of HIP-reactive and insulin-reactive T cells in NOD mice. Insulin-reactive T cells encounter their antigen early in disease, but they express FoxP3 and therefore may contribute to immune regulation. In contrast, HIP-reactive T cells are proinflammatory and highly diabetogenic in an adoptive transfer model. Because the frequency of antigen-experienced HIP-reactive T cells increases over progression of disease, they may serve as biomarkers of autoimmune diabetes.
Hypolipidemic Effect of Blended Oil in Hamster: Biochemical Analysis and Gene Expression Profiling (2016)

Edible oils form an essential part of the modern diet. Cardiovascular disease (CVD) has become one of the leading causes of death worldwide. Dietary supplementation with certain edible oils may play a vital role in improving cardiovascular health and reducing the mortality rate due to heart disease. Palm oil (PO), sunflower oil (SFO), soybean oil (SBO) and blended oils (consisting of olive oil (OLO) with SFO or SBO), were prepared (65-69% MUFA) to provide higher amounts of MUFA. Animal experiments were carried out to find the effects of olive oil blends, by feeding hamsters diets containing 8% of either native or blends of oils for 60 days. Serum cholesterol levels were reduced by 27% and 29%, respectively, in hamsters given blended oils containing OLO/SFO and OLO/SBO compared to PO. Fecal cholesterol and thiobarbituric acid did not show a significant change when hamsters were given blends in comparison with PO. Body and liver weights were also not significantly affected. These studies indicated that the atherogenic potentials of PUFA-rich SFO and SBO can be significantly decreased by blending with an oil rich in MUFA, such as OLO, in appropriate amounts. These results illustrate that blended oil significantly affects the gene expression of lipoprotein and fatty acid transporter in hamster hepatocytes. Dietary blended oil up-regulated the mRNA levels of lipin, while it down-regulated lipoprotein and cytochrome P450s. The effects of blended oil on the aforementioned genes, except lipoprotein, could be extrapolated towards decreased LDL oxidation. These findings suggest that dietary blended oil and PO alter the expression of different genes associated with contact of lipoprotein in liver.
Centered and staggered Fourier derivatives and Hilbert transforms (2002)

Abstract When ringing derivatives are used in seismic modeling, migration, and other wave propagation problems in heterogeneous media, they interact with boundaries of blocks or layers of different physical properties, generating noncausal and nonphysical waves. These spurious waves can be as strong as reflected or converted waves and other legitimate physical events, leading to errors and misinterpretations. Therefore, compact (i.e., short and nonringing) derivatives should be used.
[Clinical effects of lipo-prostaglandin E1 in patients with delayed cerebral vasospasm]. (1987)

Prostaglandin (PG) E1 is a potent vasodilator on the peripheral vessels and also has an inhibitory action of platelet aggregation. Thus it is expected that PGE1 may be used for the treatment of cerebral vasospasm in aneurysmal subarachnoid hemorrhage. Lipo-PGE1, the lipid emulsified PGE1, is not destroyed in the lung, has much longer half life in the circulation than PGE1 which is rapidly inactivated in the lung. The effects of intravenous injection of lipo-PGE1 on the cerebral hemodynamics and the central conduction time (CCT) of the sensory evoked potential under vasospastic conditions has been studied in eight patients. All these 8 patients demonstrated severe angiographic vasospasm and signs of cerebral ischemia. The 15-20 micrograms of lipo-PGE1 was administered every eight hours for 5 to 7 days. Within 6 hours of the first lipo-PGE1 treatment, the regional cerebral blood flow (rCBF) and the CCT measurements were reported to document the effect of treatment. The average pretreatment of rCBF on the right anterior, middle and posterior cerebral artery were 46.6 +/- 6.8, 56.4 +/- 7.3 and 58.8 +/- 8.9 ml/100 g/min and on the left side were 52.1 +/- 9.2, 49.1 +/- 10.8 and 56.1 +/- 9.2 ml/100 g/min respectively. With treatment these flows increased to 53.0 +/- 6.9, 64.3 +/- 5.3 and 63.0 +/- 4.6 ml/100 g/min respectively on the right side and 60.8 +/- 9.4, 60.6 +/- 9.7 and 60.6 +/- 7.2 ml/100 g/min respectively on the left. The CCT also demonstrated the improvement from 6.36 msec to 6.21 msec by the initial PGE1 treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Multidrug Resistance Reversal Agent, NSC77037, Identified with a Cell-Based Screening Assay (2010)

The development of multidrug resistance (MDR) remains a significant obstacle in treating cancer patients with chemotherapy. To identify small-molecule compounds that can reverse MDR, the authors used a cell-based screening assay with an MDR ovarian cancer cell line. Incubating MDR cells with a sublethal concentration of paclitaxel in combination with each of 2000 small-molecule compounds from the National Cancer Institute Diversity Set Library, they identified NSC77037. The cytotoxic activity of NSC77037 and the duration of its effect were evaluated in vitro using a panel of cancer cell lines expressing permeability glycoprotein (Pgp), multiple drug resistance protein 1 (MRP 1), and breast cancer resistance protein (BCRP). The mechanism of its effects was further analyzed by assessing the retention of calcein and Pgp-ATPase activity. The relative potency of MDR reversal by NSC77037 was significantly higher than that of frequently used MDR reversal agents such as verapamil and cyclosporine A. NSC77037 reversed Pgp without reversing MRP or BCRP-mediated MDR. NSC77037, at a concentration of >10 microM, moderately inhibited the proliferation of both sensitive and resistant cell lines, but the inhibitory effect of NSC77037 was not altered by coincubation with the Pgp inhibitor verapamil, suggesting that NSC77037 itself is not a substrate of Pgp. NSC77037 directly inhibited the function of Pgp in a dose-dependent manner, but it did not alter the protein expression level of Pgp. The use of NSC77037 to restore sensitivity to chemotherapy or to prevent resistance could be a potential treatment strategy for cancer patients.
A discussion of the issue of football helmet removal in suspected cervical spine injuries. (1993)

In some areas, it is a commonly accepted emergency medical technician protocol to remove a helmet during the initial management of suspected cervical spine injures. After a comprehensive survey of relevant literature, four primary reasons why Emergency Medical Services professionals would desire to remove a helmet emerge. Sources suggest that the presence of a helmet might: 1) interfere with immobilization of the athlete; 2) interfere with the ability to visualize injuries; 3) cause hyperflexion of the cervical spine; and 4) prevent proper airway management during a cardiorespiratory emergency. Many available protocols are designed for the removal of closed chamber motorcycle helmets that do not have removable face masks. There are a great number of differing viewpoints regarding this issue. The varying viewpoints are results of the failure of many emergency medical technician management protocols to address the unique situation presented by a football helmet. We: 1) demonstrate that football helmet removal is potentially dangerous and unnecessary, 2) suggest that cardiorespiratory emergencies can be effectively managed without removing the helmet, and 3) provide sports medicine professional with information that may be used to establish a joint Emergency Medical Services/Sports Medicine emergency action plan.
150 W board mounted power supply module using highly compact and efficient synchronous rectifiers (2002)

A highly efficient low-profile 150 W DC-DC converter module has been successfully developed for telecommunication systems. This module has an efficiency up to 85% and is only 12.7 mm high. Total power loss and the height are reduced by using synchronous output rectifiers, low-profile flat E-core transformer with planar windings, a nondissipative turnoff snubber and using optimum switching frequency. Its volume is 45.26 cm/sup 3/ and its power density is 3.3 W/cm/sup 3/. This module can operate at the standard industrial temperature range of -25/spl deg/C/spl sim/+85/spl deg/C under forced air convection with a heat-sink.
ChemInform Abstract: Tandem Michael Addition‐(3,3)Sigmatropic Rearrangement Processes. Part 2. Construction of Cyclopropa(3,4)pyrrolo(3,2‐e)indol‐4‐one (CPI) Unit of Antitumour Antibiotic CC‐1065. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of the PMT Gene Family in Cryptococcus neoformans (2009)

These findings suggest that C. neoformans protein-O-mannosyltransferases play a crucial role in maintaining cell morphology, and that reduced protein-O-glycosylation leads to alterations in stress resistance, cell wall composition, cell integrity, and survival within the host.
改造保守主义——评克莱格·席勒著《保守派的内疚》 (1980)

近来美国右翼思想的传统派和自由意志派的各种代言人都支持这样一种观点,即认为大多数美国人的感情实际上倾向于“保守”,持这类观点的人往往把美国社会中的反对新政者同支持新政者中间的稳健派联在一起,从而把那些依然信奉宗教和道德标准,同时又对祖国保持忠诚感的人也包括在其中。新多数派的代表人物已用冲淡同美国右翼思想有关联的易于引
Optimization of Droplet Generation by Controlling PDMS Surface Hydrophobicity (2004)

This paper presents an optimized method for droplet generation in PDMS microchannels. With controllable PDMS surface hydrophobicity and hydrophobicity recovery, alternative component droplets can be generated as anticipated. Different surface hydrophobicity results in different droplet generation patterns. Monodispersed water-in-oil and oil-in-water droplets are generated from hydrophilic and hydrophobic surface respectively. Nearly hydrophilic surface (30°&lt;θ&lt;50°) results in long-tailed droplets and less hydrophilic surface (70°&lt;θ&lt;80°) results in stream mixing. Discussion of methods to loss and recovery hydrophobicity of PDMS also included.
Contrast-enhanced color Doppler ultrasonography increases diagnostic accuracy for soft tissue tumors (2014)

Resolution of ultrasonography (US) has undergone marked development. Additionally, a new-generation contrast medium (Sonazoid) used for US is newly available. Contrast-enhanced US has been widely used for evaluating several types of cancer. In the present study, we evaluated the ability of color Doppler US (CDUS) and Sonazoid to differentiate between benign and malignant soft tissue tumors. A total of 180 patients (87 male, 93 female) were enrolled in the present study. The patient ages ranged from 1 to 91 years (mean 58.1±20.0 years). The maximum size, depth, tumor margins, shape, echogenicity and textural pattern were measured on gray-scale images. CDUS was used to evaluate the intratumoral blood flow with and without Sonazoid. Peak systolic flow velocity (Vp), mean flow velocity (Vm), resistivity index (RI) and pulsatility index (PI) of each detected intratumoral artery were automatically calculated with power Doppler US (PDUS). The present study included 118 benign and 62 malignant tumors. Statistical significances were found in size, depth, tumor margin and textural pattern but not in shape or echogenicity on gray-scale images. Before Sonazoid injection, CDUS findings showed 55% sensitivity, 77% specificity and 69% accuracy, whereas contrast-enhanced CDUS showed 87% sensitivity, 68% specificity and 74% accuracy. There were no statistically significant differences between malignant and benign tumors regarding the mean Vp, Vm, RI and PI values determined on PDUS. In conclusion, contrast-enhanced CDUS proved to be a reliable diagnostic tool for detecting malignant potential in soft tissue tumors.
Recent Advances in Combination Treatments for Photoaging: Review of the Literature (2010)

Review of the literature demonstrates the progress of dermatologic science in understanding the cellular and molecular mechanisms of ultraviolet light-induced damage and in the development of novel combination approaches for repair of photodamage and prevention of cutaneous malignancy.
Using Smartphones to Enable Situation Awareness on Highways (2010)

Motivated by the proliferation of Smartphone devices, the authors present a system architecture to enable the delivery and exchange of intelligent transportation systems (ITS) messages to Smartphones on the road. The purpose is to provide an ITS situation awareness system architecture that would enable application developers to build Smartphone applications for ITS mobility and safety. The authors present a “Slow Traffic Ahead” application as a means to validate the architecture and perform a field experiment in the San Francisco Bay Area comprised of 30 users to test the performance of the system. The authors conclude the paper with the data analysis and recommendations for improving the configurable parameters of the system architecture to provide better user experience and more accurate timing of alerts.
The RNA polymerase II ternary complex cleaves the nascent transcript in a 3'----5' direction in the presence of elongation factor SII. (1992)

The process by which RNA polymerase II elongates RNA chains remains poorly understood. Elongation factor SII is known to be required to maximize readthrough at intrinsic termination sites in vitro. We found that SII has the additional and unanticipated property of facilitating transcript cleavage by the ternary complex. We first noticed that the addition of SII caused a shortening of transcripts generated by RNA polymerase II at intrinsic termination sites during transcription reactions in which a single NTP was limiting. Truncation of the nascent transcript was subsequently observed using a series of ternary complexes artificially paused after the synthesis of 15-, 18-, 20-, 21-, and 35-nucleotide transcripts. Transcripts as short as 9 or 10 nucleotides were generated in 5-min reactions. All of these shortened RNAs remained in active ternary complexes because they could be chased quantitatively. Continuation of the truncation reaction produced RNAs as short as 4 nucleotides; however, once cleavage had proceeded to within 8 or 9 bases of the 5' end, the resulting transcription complexes could not elongate the RNAs with NTP addition. Transcript cleavage requires a divalent cation, appears to proceed primarily in 2-nucleotide increments, and is inhibited by alpha-amanitin. The catalytic site of RNA polymerase II is repositioned after transcript cleavage such that polymerization resumes at the proper location on the template strand. The extent and kinetics of the transcript truncation reaction are affected by both the position at which RNA polymerase is halted and the sequence of the transcript.