gebhart/patrepeval huggingface dataset:
Paramagnetism at Ambient Temperature, Diamagnetism at Low Temperature in a Ru<sub>2</sub><sup>6+</sup> Core:  Structural Evidence for Zero-Field Splitting (2004)

Variable temperature magnetic studies of the Ru(2)(6+) guanidinate compounds Ru(2)(hpp)(4)Cl(2) (1) and Ru(2)(hpp)(4)(CF(3)SO(3))(2) (2) show that they are paramagnetic with two unpaired electrons at room temperature and that they appear essentially diamagnetic at 2 K. In neither compound do the Ru-Ru distances vary by more than 0.008(1) A from 27 to 296 K. This argues strongly that the ground state electronic configuration remains constant over this temperature range and that the decrease in magnetism as the temperature is lowered must be attributable to zero-field splitting of the (3)A(2g) ground state arising from the electronic configuration sigma(2)pi(4)delta(2)pi(2). The Ru-Ru distance in 1 is about 0.04-0.05 A longer than that in 2 which indicates that the Ru(2)(hpp)(4)(2+) core is quite sensitive to the nature of the axial ligands. The electronic spectra show three absorption bands for each compound.
Lactose Intolerance and Self-Reported Milk Intolerance: Relationship with Lactose Maldigestion and Nutrient Intake (1998)

In studies of the general population, the frequency of lactose intolerance is much lower than that of lactose maldigestion. Gastrointestinal symptoms after lactose load in self-reported milk-intolerants are found in only a very low number of these subjects. Furthermore, in these subjects we observed an unnecessary reduction in milk consumption and an insufficient dietary calcium intake.
DPS: dynamic priority scheduling heuristic for heterogeneous computing systems (1998)

Scheduling a parallel program is a crucial step in effectively harnessing the computing power of a heterogeneous computing system. Obtaining a minimum finish time schedule for a set of precedence constrained tasks is a well known NP-complete problem. Heterogeneity in parallel systems introduces an additional degree of complexity to the scheduling problem, i.e. varying speed of processors. A non-preemptive, compile-time scheduling heuristic has been developed, designated as DPS, that uses dynamic priorities based on the difference between b-level and t-level to map and schedule directed acyclic graphs (DAGs) onto heterogeneous processors, with the objective of minimising the schedule length. In the case of homogeneous processors, it is not difficult to compute the b-level and t-level, since the task execution costs are fixed. However, in the case of heterogeneous processors, as each task has a different execution cost on each processor, the b-level and t-level lose their traditional meaning. The b-level and t-level have been computed in a different and effective way that captures the changes which occurred in the DAG during scheduling. Dynamic priorities are thus determined during the scheduling process in order to avoid scheduling less important tasks before the more important ones. Moreover, the effect of changing the task execution cost to compute the b-level and t-level has also been studied. The effectiveness of the algorithm is demonstrated by comparing it against two of the existing closely related algorithms for randomly generated graphs. DPS outperforms both algorithms by a considerable margin and has a reasonable time complexity.
Alcoa: The Influence of Recycling on Monopoly Power (1980)

Puzzle 1: Was Judge Hand correct in his celebrated judicial opinion that Alcoa's monopoly in "virgin" aluminum provided indirect control over "secondary" production? Answer: Estimates based on three models suggest that the "procompetitive" effect of recycling was largely offset by a reduction in virgin production in anticipation of future conversion into secondary. Thus, Hand's judgment appears sound. Puzzle 2: Is it in Alcoa's own interests to suppress recycling of scrap aluminum if feasible? Answer: If current users show that they value the future use of the product by selling scrap to merchants, then Alcoa is likely to value the recycling market also. If users discard scrap which is subsequently scavenged, then Alcoa is likely to be harmed by such activity.
Erratum: Kinetic behaviour of the cells touching substrate: the interfacial stiffness guides cell spreading (2014)

To describe detailed behaviour of cell spreading under the influence of substrate stiffness, A549 cells cultured on the surfaces of polydimethylsiloxane (PDMS) and polyacrylamide (PAAm) with bulk rigidities ranging from 0.1 kPa to 40 kPa were in situ observed. The spreading behaviour of cells on PAAm presented a positive correlation between spreading speed and substrate stiffness. After computing the deformations of PAAm gels and collagen, the bulk stiffness of PAAm, rather than matrix tethering, determined the cell behaviour. On the other hand, spreading behaviour of the cells was unaffected by varying the bulk stiffness of PDMS. Based on simulation analyses, the elasticity of silica-like layer induced by UV radiation on PDMS surface dominated cell-substrate interaction, rather than the bulk stiffness of the material, indicating that it is the interfacial stiffness that mainly guided the cell spreading. And then the kinetics of cell spreading was for the first time modeled based on absolute rate theory.
[Evaluation of an antioxidant and mitochondria-stimulating cream formula on the skin of patients with stable common vitiligo]. (2007)

Vitiligo is a chronic illness of a yet unknown etiology, characterized by an acquired and progressive depigmentation of the skin. There are diverse treatments for this condition around the world, but up to now, none has been completely effective. The objective of this work was to evaluate the application of an antioxidant and mitochondrial stimulating formula, of topic use in leukodermic areas of patients with stable vulgar vitiligo. A clinical, experimental, randomized, double blind study was carried out in 50 male and 50 female patients with stable vulgar vitiligo. The patients were distributed in five groups as follows: Group 1 (labelled as VitilVenz AF): application of antioxidant and mitochondrial stimulating cream and oral administration of antioxidants and phenylalanine. Group 2 (labelled as Placebo AF): application of a placebo cream and oral administration of antioxidants and phenylalanine. Group 3 (labelled as without cream AF): oral administration of antioxidants and phenylalanine. Group 4 (labelled as Placebo cream): application of a placebo cream. Group 5 (labelled as VitilVenz): application of the antioxidant and mitochondrial stimulating cream. The following were measured in all patients: the clinical area of newly formed pigment every 30 days, during five months; and the presence of melanocytes in the histological study, at the beginning and at the end of treatment. The test of multiple comparison of Turkey-Kramer was used for the analysis of the results. The scheme of treatment that produced the best results was that of the Group 1, which consisted of the joint application of the antioxidant and mitochondrial stimulating cream and oral administration of antioxidants and phenylalanine (p < 0.001); followed by Group 5 that only received the topical treatment with the antioxidant and mitochondrial stimulating cream. The clinical and histological responses of these two groups (1 and 5) were significantly different to the rest of the groups. We concluded that the melanocytes in these patients could be in a dysfunctional state, product of the formation of free radicals that cause cellular and mitochondrial toxicity; and that these free radicals are removed by the antioxidant and mitochondrial stimulating elements present in the cream, turning the melanocytes functional and producing melanin in the achromic area of the vitiligo. This effect would be potentiated by the use of oral antioxidants and phenylalanine.
Steam Sterilization of Air Turbine Dental Handpieces (1983)

The efficacy of autoclaving high-speed dental handpieces was tested in two types of downward displacement steam sterilizers (instrument autoclaves), commonly used in the dentist's office. Eight series of experiments were performed with various sterilization schedules. Lubrication oils with or without antimicrobial agent were used in four of the series. Each handpiece was inoculated with 1 ml of a suspension containing equal amounts of saliva and spores of Bacillus stearothermophilus (approx. 10(6) spores/ml). Neither sterilization at 120-124 degrees C for 20 min nor at 134-136 degrees C for 10 min resulted in complete inactivation of the spores in series in which the instruments were tested without oil or with oil containing no antimicrobial agent. However, when the handpieces were lubricated with oil containing isopropanol and formaldehyde and the schedule 134-136 degrees C/10 min was used, no growth was observed. The results indicate that instrument autoclaves with built-in programs of 120-124 degrees C/20 min and 134-136 degrees C/10 min could have insufficient capacity to sterilize lubricated or unlubricated dental handpieces. The use of oils containing an antimicrobial agent can overcome this problem.
ADAM17-Mediated Shedding of FcγRIIIA on Human NK Cells: Identification of the Cleavage Site and Relationship with Activation (2013)

FcγRIIIA/CD16A, the low-affinity receptor for the IgG Fc portion expressed on human CD56(dim) NK cells and involved in Ab-dependent cell cytotoxicity, is shed upon NK cell activation. We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ectodomain of FcγRIIIA/CD16A and a peptide for which the sequence encompasses aa 191-201 of the FcγRIIIA/CD16A stalk region but not ADAM10. MALDI-TOF analysis revealed that the peptide was cleaved between Ala(195) and Val(196) (i.e., 1 aa upstream of the expected position). This location of the cleavage site was confirmed by the finding that ADAM17 failed to cleave a peptide in which Ala and Val were reversed. ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcγRIIIA/CD16A and CD62L, a specific substrate of ADAM17. Selective inhibition of ADAM17 prevented the shedding of both molecules. Moreover, the shedding of FcγRIIIA/CD16A was strongly correlated with degranulation when a wide range of CD56(dim) NK cell activating receptors were stimulated, whereas both ADAM17-dependent shedding and internalization were involved in FcγRIIIA/CD16A downmodulation when the latter was engaged. Finally, the shedding of FcγRIIIA/CD16A was restricted to activated cells, suggesting that ADAM17 acts mainly, if not exclusively, in cis. Taken together, our results demonstrated for the first time, to our knowledge, at the molecular level that ADAM17 cleaves the stalk region of FcγRIIIA/CD16A and identified its cleavage site. The shedding of FcγRIIIA/CD16A was at least partially ADAM17 dependent, and it may be considered as a marker of FcγRIIIA/CD16A-independent NK cell activation highly correlated with degranulation.
The Leishmania ATP-binding Cassette Protein PGPA Is an Intracellular Metal-Thiol Transporter ATPase (2001)

The Leishmania ATP-binding cassette (ABC) transporter PGPA is involved in metal resistance (arsenicals and antimony), although the exact mechanism by which PGPA confers resistance to antimony, the first line drug against Leishmania, is unknown. The results of co-transfection experiments, transport assays, and the use of inhibitors suggest that PGPA recognizes metals conjugated to glutathione or trypanothione, a glutathione-spermidine conjugate present in Leishmania. The HA epitope tag of the influenza hemagglutinin as well as the green fluorescent protein were fused at the COOH terminus of PGPA. Immunofluorescence, confocal, and electron microscopy studies of the fully functional tagged molecules clearly indicated that PGPA is localized in membranes that are close to the flagellar pocket, the site of endocytosis and exocytosis in this parasite. Subcellular fractionation of Leishmania tarentolae PGPAHA transfectants was performed to further characterize this ABC transporter. The basal PGPA ATPase activity was determined to be 115 nmol/mg/min. Transport experiments using radioactive arsenite-glutathione conjugates clearly showed that PGPA recognizes and actively transports thiol-metal conjugates. Overall, the results are consistent with PGPA being an intracellular ABC transporter that confers arsenite and antimonite resistance by sequestration of the metal-thiol conjugates.
On threshold circuits for parity (2002)

Motivated by, the problem of understanding the limitations of neural networks for representing Boolean functions, the authors consider size-depth tradeoffs for threshold circuits that compute the parity function. They give an almost optimal lower bound on the number of edges of any depth-2 threshold circuit that computes the parity function with polynomially bounded weights. The main technique used in the proof, which is based on the theory of rational approximation, appears to be a potentially useful technique for the analysis of such networks. It is conjectured that there are no linear size, bounded-depth threshold circuits for computing parity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pressure Monitoring Devices (1976)

Contaminated pressure monitoring devices recently have been implicated as a source of epidemic organisms in three outbreaks of nosocomial bacteremia, one outbreak of candidemia, and one outbreak of hepatitis. Measures necessary to prevent monitoring-related infections have not always been appreciated or taken. As a minimum, pressure monitoring devices should be sterilized between use with different patients; strict aseptic technique should be employed when setting up and using monitoring systems; and each patient's monitoring tubing, fluid, and monitoring devices should be changed at regular intervals. (<i>JAMA</i>236:936-938, 1976)
The Spiral Compression Plate for Proximal Humeral Shaft Nonunion: A Case Report and Description of a New Technique (1999)

We present a case of humeral nonunion managed with a dynamic compression plate (DCP) contoured in a spiral fashion to preserve the deltoid muscle insertion. A forty-one-year-old woman sustained a closed proximal third humeral shaft fracture with an associated supraclavicular brachial plexus injury. She presented five months later with an atrophic nonunion of the proximal humeral shaft, inferior subluxation of the humeral head, and a resolving brachial plexopathy. Autogenous cancellous bone grafting and open reduction and internal fixation with a narrow DCP was performed. The deltoid muscle insertion was preserved by contouring the plate to fix the proximal humerus laterally over the greater tuberosity and anteriorly over the mid-humeral shaft. During the postoperative period, the humeral head reduced spontaneously. Five months after surgery, the fracture healed, and an excellent clinical result was achieved. We recommend the use of the spiral DCP for proximal shaft fractures and nonunions when preservation of the deltoid insertion is desirable.
Adhesion and Fitness in the Bean Phyllosphere and Transmission to Seed of <i>Xanthomonas fuscans</i> subsp. <i>fuscans</i> (2009)

Deciphering the mechanisms enabling plant-pathogenic bacteria to disperse, colonize, and survive on their hosts provides the necessary basis to set up new control methods. We evaluated the role of bacterial attachment and biofilm formation in host colonization processes for Xanthomonas fuscans subsp. fuscans on its host. This bacterium is responsible for the common bacterial blight of bean (Phaseolus vulgaris), a seedborne disease. The five adhesin genes (pilA, fhab, xadA1, xadA2, and yapH) identified in X. fuscans subsp. fuscans CFBP4834-R strain were mutated. All mutants were altered in their abilities to adhere to polypropylene or seed. PilA was involved in adhesion and transmission to seed, and mutation of pilA led to lower pathogenicity on bean. YapH was required for adhesion to seed, leaves, and abiotic surfaces but not for in planta transmission to seed or aggressiveness on leaves. Transmission to seed through floral structures did not require any of the known adhesins. Conversely, all mutants tested, except in yapH, were altered in their vascular transmission to seed. In conclusion, we showed that adhesins are implicated in the various processes leading to host phyllosphere colonization and transmission to seed by plant-pathogenic bacteria.
Implementation of a High-Rate USB Data Acquisition System for PET and SPECT Imaging (2006)

We made substantial progress with a flexible high-rate USB data acquisition system developed for gamma-ray imaging detectors. Hardware consists of 16-channel data acquisition modules installed on USB carrier boards. One, two, and four-module units were developed. USB data rate was increased to over 30 MB/s and a 16-channel configuration achieved a trigger rate of over 700 kHz. Several high-resolution single-gamma detectors and two high-rate PET detectors were instrumented. The detectors use various configurations of Hamamatsu H8500, H9500, and Burle 85002-800 PSPMTs. System channels were expanded by synchronizing additional acquisition units. A Java client-server system was developed to link acquisition computers over Gigabit Ethernet. A Kmax tool was developed to process and display images during acquisition. C and Java utilities were developed to assist development and diagnostics.
Influence of coronary vessel size on renarrowing process and late angiographic outcome after successful balloon angioplasty. (1994)

Increasing coronary vessel size was found to be independently predictive of decreasing late luminal loss and increasing follow-up MLD after successful balloon angioplasty. Apparently superior or inferior late angiographic results of new interventional devices may thus be explained in part by preferential use in larger or smaller vessels, respectively. Devices that can safely optimize the short-term result of intervention may realize their ultimate long-term value in larger coronary vessels.
Allergen‐induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34<sup>+</sup> cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation (2003)

There is increasing evidence that primitive progenitors migrate from the bone marrow (BM) via the peripheral circulation to tissue sites where they undergo in situ differentiation to provide a continued source of effector cells, such as eosinophils, during an allergic inflammatory response. To study mechanisms of progenitor cell mobilization in allergic reactions, we investigated fluctuations in the expression of the eotaxin receptor, CC chemokine receptor 3 (CCR3), on CD34+ cells from stable asthmatics following allergen (i.e. antigen) challenge. BM aspirates were taken from seven early responder (ER) and 10 dual responder (DR) asthmatics who, following antigen challenge developed only an early bronchoconstrictor response and an early and late- bronchoconstrictor response, respectively. Expression of CCR3 was detected on primitive (CD34+ cells) and eosinophil-lineage committed progenitors (CD34+ interleukin-5 receptor alpha-subunit+ cells) by flow cytometry and confirmed by co-localization of CCR3 messenger RNA to CD34 immunopositive cells using in situ hybridization. When preantigen levels were compared to 24-hr postantigen levels, significant increases in BM CD34+ CCR3+ cells were detected in DR, who also developed a significant sputum and blood eosinophilia and increased methacholine airway responsiveness. In contrast, a significant attenuation of BM CD34+ CCR3+ cells was observed in ER. In a dose-dependent manner eotaxin, but not interleukin (IL)-5, stimulated CD34+ progenitor cell migration in vitro. This migrational response to eotaxin was abrogated by anti-CCR3 monoclonal antibody and primed by preincubation with IL-5. We propose that fluctuations in CCR3 expression on human BM CD34+ cells may facilitate chemokine-mediated progenitor cell mobilization to the peripheral circulation and the resultant development of pulmonary eosinophilia, a cardinal feature of asthma.
Molecular mechanisms involved in human autoimmune diseases: relevance of chronic antigen presentation. Class II expression and cytokine production. (1989)

The observation that the local site of autoimmune responses over-expressed HLA class II led to the formulation that tissue antigen-presenting capacity contributes significantly to the mechanism of autoimmune disease perpetuation, by continually reactivating auto-antigen-reactive T lymphocytes. These in turn produce mediator molecules which maintain HLA class II expression (and hence antigen-presenting capacity) in the target tissues; and also initiate the immune and inflammatory pathways. The importance of this concept is that it provides a readily testable hypothesis that has been investigated extensively. For the thyroid diseases compelling data to support it have accumulated; in other diseases such as rheumatoid arthritis the evidence is increasing. The concept also relates the human autoimmune diseases to the normal mechanisms of immune induction and immunoregulation. This highlights the areas that we do not yet understand, namely the interplay of genetic susceptibility, extrinsic agents or disorders of immune regulation which permit the autoimmune process to become sufficiently pronounced as to engender a clinical autoimmune disease. Even with our limited understanding of the disease process, it is apparent that there are many opportunities for newer approaches at therapy, based on interfering with the immune cells or their mediators.
Preparation and circular dichroism analysis of sodium hyaluronate oligosaccharides and chondroitin (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and circular dichroism analysis of sodium hyaluronate oligosaccharides and chondroitinMary K. Cowman, Endre A. Balazs, Carl W. Bergmann, and Karl MeyerCite this: Biochemistry 1981, 20, 5, 1379–1385Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/bi00508a053https://doi.org/10.1021/bi00508a053research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Flexible parallel implementation of LLR BP decoding simulation on multicores using OpenCL (2017)

In this paper we explore acceleration of the logarithmic likelihood ratio (LLR) belief propagation (BP) algorithm for LDPC codes decoding simulation, using parallel computation on graphics processing units (GPUs) with OpenCL technology. The proposed parallel implementation of the LLR BP algorithm includes parallel version of all decoding steps: decoder initialization, check and variable nodes update, a posteriori LLR calculation and decoding termination check. Decoder throughput was measured by simulating data transmission system with LDPC coding for DVB-T2/S2 (64800, 32400) and PEG (1008, 504) codes.