gebhart/patrepeval huggingface dataset:
[(Arylpiperazino-4-butyryl)-6 benzoxazolinones and reduction products: chemistry and pharmacodynamic study]. (1989)

The synthesis of various 6-(4-arylpiperazino-butyryl)-3-methyl-benzoxazolinones and their reduction products, 6-(4-arylpiperazino-1-hydroxy-butyl)-3-methyl-benzoxazolinones and 6-(4-arylpiperazino-butyl)-3 methyl-benzoxzolinones, is described. These compounds were tested for psychotropic and analgesic activities.
Kinetic Resolution of Chiral Auxiliaries with C2-Symmetry by Lipase-Catalyzed Alcoholysis and Aminolysis. (1996)

Three cyclic diols, 1,2-cyclohexanediol (1), 1,3-cyclohexanediol (2), and 1,3-cyclopentanediol (3), two acyclic unsaturated diols, 1,5-hexadiene-3,4-diol (4) and 1,7-octadiyne-3,6-diol (5), and a cyclic diamine, 1,2-cyclohexanediamine (6), have been kinetically resolved in alcoholysis and aminolysis reactions, catalyzed by Candida antarctica component B lipase, using S-ethyl thiooctanoate or ethyl octanoate as acyl donors. Acceptable stereoselectivity was achieved in most cases.
Ontogeny of glycine transport in isolated rat renal tubules (1977)

Isolated renal tubule preparations were made from newborn Sprague-Dawley rats and used to study initial entry rate kinetics of glycine. The results were compared to those obtained in the isolated tubule preparation from the adult rat kidney. While initial rates of glycine uptake were identical for newborn and adult tubules, significant differences in influx kinetics were demonstrated. Of the two apparent transport Km systems shown to be present in the newborn tubule, the high-affinity, low-capacity system accounts for about 40% of total glycine uptake at physiologic concentrations. The high-affinity, low-capacity system of the adult tissue accounts for about 10% of total uptake at the same concentration range. The data lend strength to the argument against the concept that the physiologic hyperglycinuria of the newborn rat is due to either impaired ability to concentrate glycine intracellularly or to absence of one or more transport mechanisms for glycine.
Conformation of Secondary Amides. A Predictive Algorithm That Correlates DFT-Calculated Structures and Experimental Proton Chemical Shifts (2003)

The magnetic deshielding caused by the amido group on CON-CHalpha protons of secondary amides can easily be correlated with DFT-based structures at the B3LYP/6-31G level of theory via a novel algorithm that refines previous models, such as the classical McConnell equation. The shift is given by delta = a + 2.16 cos2(alpha - 35)/d, where alpha denotes the virtual dihedral angle resulting from linking the carbonyl and the alpha-carbons and d is the distance (A) between the shifted proton and the carbonyl oxygen. Notably, in this equation a is a parameter that can be optimized for different solvents, namely, CDCl3, DMSO-d6, and D2O. For the development of these correlations, the preferential conformation of amides is taken from the optimized structures in the gas phase obtained at the DFT level. The deshielding on anti and gauche protons in both rotamers of (Z)-acetamides and E/Z isomers of formamides has been evaluated. This methodology has proved to be highly reliable, allowing us to discard ab initio or DFT conformational arrangements when shifts calculated by the above-mentioned equation differ from the experimental values. Thus, the anti disposition between the CHalpha proton and the N-H bond appears to be the more stable conformation of simple amides. For amides bearing only one proton at Calpha, a local syn minimum can equally be characterized. The rotational barriers around the CON-alkyl bond along with the pyramidalization of the amido group have also been reassessed. As the conformation is taken away from anti or local syn minima, the nonplanarity of the amido group appears to increase.
Mining text snippets for images on the web (2014)

Images are often used to convey many different concepts or illustrate many different stories. We propose an algorithm to mine multiple diverse, relevant, and interesting text snippets for images on the web. Our algorithm scales to all images on the web. For each image, all webpages that contain it are considered. The top-K text snippet selection problem is posed as combinatorial subset selection with the goal of choosing an optimal set of snippets that maximizes a combination of relevancy, interestingness, and diversity. The relevancy and interestingness are scored by machine learned models. Our algorithm is run at scale on the entire image index of a major search engine resulting in the construction of a database of images with their corresponding text snippets. We validate the quality of the database through a large-scale comparative study. We showcase the utility of the database through two web-scale applications: (a) augmentation of images on the web as webpages are browsed and (b)~an image browsing experience (similar in spirit to web browsing) that is enabled by interconnecting semantically related images (which may not be visually related) through shared concepts in their corresponding text snippets.
The trkA Receptor Mediates Growth Cone Turning toward a Localized Source of Nerve Growth Factor (1997)

We have developed an in vitro system for studying the interaction of chick dorsal root ganglion neuronal growth cones with a localized source of nerve growth factor (NGF) covalently conjugated to polystyrene beads. Growth cones rapidly turned and migrated under NGF-coated beads in a process that involved the initial formation of persistent contact with a bead, followed by directed flow of cytoplasm toward the point of contact. A role for the local activation of the high-affinity NGF receptor trkA was suggested by a strong inhibition of the turning response by (1) the addition of an antibody against the extracellular portion of trkA, (2) the elevation of the background concentration of NGF to saturate trkA, or (3) the presence of a concentration of the drug K252a that inhibits trkA activation. NGF binding to the pan-neurotrophin receptor p75 is also involved but is not required for turning. These data show a new role for both the trkA and the p75 receptors: the mediation of local events in the guidance of nerve growth cones.
Synthetic aperture radar image processing on parallel supercomputers (1991)

We briefly discuss three algorithms used to process synthetic aperture radar (SAR) images: a polar reformat­ ter that maps raw SAR data to a rectangular mesh, 2-d FFTs that the data set to a real image, and phase gradient autofocusing which creates clear images by cor­ recting blurs resulting from uncompensated phase errors. Implementation details and performance data for the algo­ rithms are given for two parallel supercomputers, a nCUBE 2 hypercube and a CM-2. Portions of the algo­ rithms execute at gigaflop speeds, meaning that large SAR data sets (16,384 x 65,536) can be processed in tens of minutes instead of hours as on conventional supercomput­ ers. Equally significantly, the gigabytes of internal mem­ ory on the parallel machines allow entire images to be
Fundamental Data Retention Limits in SRAM Standby Experimental Results (2008)

SRAM leakage power dominates the total power of low duty-cycle applications, e.g., sensor nodes. Accordingly, leakage power reduction during data-retention in SRAM standby is often addressed by reducing the supply voltage. Each SRAM cell has a minimum supply voltage parameter called the data-retention voltage (DRV), above which the stored bit can be retained reliably. The DRV exhibits significant intra-chip variation in the deep sub-micron era. As supply voltage is lowered, leakage power reduces, but a larger fraction of SRAM cells is prone to retention failures. Use of appropriate error-correction to mitigate cell- reliability is proposed. Using this approach, the standby supply voltage is selected to minimize leakage power per useful bit. The fundamental limits on the leakage power per useful bit, while taking the DRV distribution into account, are established. Minimization of power per bit results in a supply-voltage at which a small fraction of cells fail to retain the data. For experimental DRV -distributions, a [31,26,3] Hamming code based implementation achieves a significant portion of the leakage power reduction compared to the fundamental limit. These analytical results are verified by twenty-four experimental chips manufactured in an industrial 90 nm CMOS process.
Preparation of Novel Poly(aryleneamine)s by Palladium Complex Catalyzed Polycondensation of Dibromobenzenes with Diamines (1996)

Abstract The reaction of aryl dibromides with secondary diamines proceeds smoothly in the presence of a stoichiometric base such as NaOtBu and a catalytic amount of palladium complex, PdCl2(P(o-tolyl)3)2 (P(o-tolyl)3 = tri-o-tolylphosphine), in toluene to give the corresponding new poly(aryleneamine)s.
Adaptive equalization (1982)

Bandwidth-efficient data transmission over telephone and radio channels is made possible by the use of adaptive equalization to compensate for the time dispersion introduced by the channel Spurred by practical applications, a steady research effort over the last two decades has produced a rich body of literature in adaptive equalization and the related more general fields of reception of digital signals, adaptive filtering, and system identification. This tutorial paper gives an overview of the current state of the art in adaptive equalization. In the first part of the paper, the problem of intersymbol interference (ISI) and the basic concept of transversal equalizers are introduced followed by a simplified description of some practical adaptive equalizer structures and their properties. Related applications of adaptive filters and implementation approaches are discussed. Linear and nonlinear receiver structures, their steady-state performance and sensitivity to timing phase are presented in some depth in the next part. It is shown that a fractionally spaced equalizer can serve as the optimum receive filter for any receiver. Decision-feedback equalization, decision-aided ISI cancellation, and adaptive filtering for maximum-likelihood sequence estimation are presented in a common framework. The next two parts of the paper are devoted to a discussion of the convergence and steady-state properties of least mean-square (LMS) adaptation algorithms, including digital precision considerations, and three classes of rapidly converging adaptive equalization algorithms: namely, orthogonalized LMS, periodic or cyclic, and recursive least squares algorithms. An attempt is made throughout the paper to describe important principles and results in a heuristic manner, without formal proofs, using simple mathematical notation where possible.
Effect of Farnesol on <i>Staphylococcus aureus</i> Biofilm Formation and Antimicrobial Susceptibility (2006)

Staphylococcus aureus is among the leading pathogens causing bloodstream infections able to form biofilms on host tissue and indwelling medical devices and to persist and cause disease. Infections caused by S. aureus are becoming more difficult to treat because of increasing resistance to antibiotics. In a biofilm environment particularly, microbes exhibit enhanced resistance to antimicrobial agents. Recently, farnesol was described as a quorum-sensing molecule with possible antimicrobial properties. In this study, the effect of farnesol on methicillin-resistant and -susceptible strains of S. aureus was investigated. With viability assays, biofilm formation assessment, and ethidium bromide uptake testing, farnesol was shown to inhibit biofilm formation and compromise cell membrane integrity. The ability of farnesol to sensitize S. aureus to antimicrobials was assessed by agar disk diffusion and broth microdilution methods. For both strains of staphylococci, farnesol was only able to reverse resistance at a high concentration (150 microM). However, it was very successful at enhancing the antimicrobial efficacy of all of the antibiotics to which the strains were somewhat susceptible. Therefore, synergy testing of farnesol and gentamicin was performed with static biofilms exposed to various concentrations of both agents. Plate counts of harvested biofilm cells at 0, 4, and 24 h posttreatment indicated that the combined effect of gentamicin at 2.5 times the MIC and farnesol at 100 microM (22 microg/ml) was able to reduce bacterial populations by more than 2 log units, demonstrating synergy between the two antimicrobial agents. This observed sensitization of resistant strains to antimicrobials and the observed synergistic effect with gentamicin indicate a potential application for farnesol as an adjuvant therapeutic agent for the prevention of biofilm-related infections and promotion of drug resistance reversal.
BALTHASAR'S ODYSSEY (Book) (2002)

In this study, we hypothesized that traditionalist social attitudes (conservatism, religiousness, and authoritarianism) significantly predict COVID-19 conspiracy beliefs (Hiding Information and Harmless Virus), as well as conspiracy mentality in general. We also hypothesized that these relationships are mediated by the objectivity of the media through which individuals inform themselves, and the frequency with which people informed themselves about the pandemic. The sample consisted of 341 participants from Serbia (mean age 33.51 years), of which 40.5% were women. The results revealed that conservatism predicts both conspiracy belief sets and conspiracy mentality, authoritarianism only COVID-19 conspiracy beliefs, and religiousness only beliefs that the virus is harmless. Media objectivity does not mediate these relationships. The frequency of informing is a significant mediator only of the relationships between authoritarianism, and conspiracy beliefs and conspiracy mentality, indicating that the role of seeking information is in reducing the threat perceived by more authoritarian individuals. The study reveals that media objectivity might not play a role in reducing conspiracy beliefs. An explanation might be found in the importance of the perceived credibility of the media.
Phantom sensations in people with complete spinal cord lesions: A grounded theory perspective (2008)

Our results provide an enhanced understanding of the embodied experience of phantom sensations, and important insights regarding self-construction and rehabilitative processes in people with spinal cord injury who experience such anomalous sensations.
A Study on Wall Surface Mobile Robots : Development of Moving Mechanism for Crawler-Type Wall Surface Mobile Robots with Vacuum Pads (1995)

We study the moving mechanism of a wall surface mobile robot for hazard maintenance under gravity. This robot can attach itself to a vertical wall or ceiling by vacuum pads. The vacuum pads are set on the crawler so as to enable rapid mobility on the surface. Each vacuum pad is simply designed. There is a mechanical valve set at each sucker, and every sucker is connected to an air duct inside the crawler belt. The valve opens mechanically when the sucker touches the surface, and the sucker clings to the surface. By this mechanism, the sucking control system becomes simple. The vacuum pad is made of flexible material in order to ensure sufficient sucking force even when the surface is rough. This robot also has an automatic pushing mechanism for the suckers and distribution mechanism. We designed, fabricated and tested the prototype. In the experiment, this robot succeeded in smoothly and rapidly climbing the surface of vertical walls and ceilings having both rough and smooth finishes.
Does a higher number of siblings protect against the development of allergy and asthma? A review (2002)

Research has not yet answered the question of which causal factors explain the sibling effect. Causal factors must meet two criteria; they must vary with sibship size and they must protect against atopic manifestations. The prevailing "hygiene hypothesis" failed to explain the findings adequately. Alternative explanations include in utero programming or endocrine explanatory models. The epidemiology research into siblings and atopic disorders has entered an intellectually challenging phase. Possessing sufficient knowledge about the causal factors might prevent at least 30% of all cases of asthma, eczema, and hay fever.
Keep it accurate and diverse: Enhancing action recognition performance by ensemble learning (2015)

The performance of different action recognition techniques has recently been studied by several computer vision researchers. However, the potential improvement in classification through classifier fusion by ensemble-based methods has remained unattended. In this work, we evaluate the performance of an ensemble of action learning techniques, each performing the recognition task from a different perspective. The underlying idea is that instead of aiming a very sophisticated and powerful representation/learning technique, we can learn action categories using a set of relatively simple and diverse classifiers, each trained with different feature set. In addition, combining the outputs of several learners can reduce the risk of an unfortunate selection of a learner on an unseen action recognition scenario. This leads to having a more robust and general-applicable framework. In order to improve the recognition performance, a powerful combination strategy is utilized based on the Dempster-Shafer theory, which can effectively make use of diversity of base learners trained on different sources of information. The recognition results of the individual classifiers are compared with those obtained from fusing the classifiers' output, showing enhanced performance of the proposed methodology.
Ischemia and reperfusion-induced histologic changes in the rat retina. Demonstration of a free radical-mediated mechanism. (1991)

Histologic alterations of ischemia- and reperfusion-induced retinal damage are critically dependent on the duration of the period of ischemia. Male Sprague Dawley rats were anesthetized, and a suture was placed behind the globe including the central retinal artery. Because it was desirable that untreated eyes show a great histologic change due to reperfusion-induced damage (in order that maximum scope would exist for demonstration of any protective effect of a drug treatment), a preliminary series of studies established the time-induced characteristics for the retina with transient regional ischemia. Eyes (n = 6-12 in each group) were subjected to 30, 60, or 90 min of ischemia followed by 0.5, 1, 2, 4, and 24 hr of reperfusion, respectively. The 30-min ischemia followed by reperfusion did not result in any histologic changes; 60-min ischemia followed by reperfusion induced a moderate retinal edema which returned to the preischemic value after 24 hr of reperfusion. The 90-min ischemia followed by reperfusion further aggravated retinal edema and increased the migration of neutrophil leukocytes. Even after 24 hr of reperfusion, the retinal edema had not disappeared although an attenuation was observed. In this study, the rats were treated with superoxide dismutase (SOD-PEG, 15 x 10(3) U/kg) or EGB 761 (100 mg/kg) for 10 days (chronic treatment). The SOD and EGB 761 significantly reduced the development of reperfusion-induced retinal edema and significantly prevented the neutrophil leukocyte infiltration. Both also had a protective effect against reperfusion-induced injury when these agents were administered just before reperfusion ("late" administration).(ABSTRACT TRUNCATED AT 250 WORDS)
Degraded axial buckling strain of multiwalled carbon nanotubes due to interlayer slips (2001)

A multiple-shell model is presented for infinitesimal axially compressed buckling of a multiwalled carbon nanotube embedded within an elastic matrix. In contrast to an existing single-shell model which treats the entire multiwalled nanotube as a singlelayer elastic shell, the present model assumes that each of the nested concentric tubes is an individual elastic shell and the deflections of all shells are coupled through the van der Waals interaction between adjacent nanotubes. By examining a doublewalled carbon nanotube, it is found that the change in interlayer spacing has a negligible effect on the axial buckling strain provided that the innermost radius is at least a few nanometers. Under this condition, a single equation is derived which determines the deflection of the multiwalled carbon nanotube, and it is shown that infinitesimal axial buckling of a N-walled carbon nanotubes is equivalent to that of a single layer elastic shell whose bending stiffness is approximately N times the effective bending stiffness of a single walled carbon nanotube. As a result, the axial buckling strain of a N-walled carbon nanotube is about 5 N times lower than that predicted by the existing single-shell model. The degraded axial buckling strain is attributed to the interlayer slips between adjacent nanotubes, which represents an essential feature of mechanical behavior of multiwalled carbon nanotubes.
Inducing Apoptosis of NCI-H157 Human Lung Carcinoma Cells via Activation of Caspase Cascade by Combination Treatment with Arsenic Trioxide and Sulindac (2004)

Arsenic trioxide(As 2 O 3 ) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia. Some investigators have reported that arsenic trioxide had induced apoptosis in a variety of solid human tumor cell lines, including non-small cell lung cancer. Non-steroidal anti-inflammatory drugs(NSAIDs) are powerful chemopreventive agents for gastrointestinal cancers and the growth of established tumors are reduced by inducing apoptosis. It's also reported that NSAIDs enhanced tumor response to chemotherapeutic drugs or radiation. In this study, we aimed to determine whether combination of arsenic trioxide with sulindac augmented its apoptotic potential in NCI-H157 human lung cancer cells.
Svensk Utrikespolitik*) (1969)

3 SVENSK UTRIKESPOLITIK*) Av utrikesminister TORSTEN NILSSON En av de mest valkanda händelserna i Sveriges historia ar Karl XII :s ritt genom Europa. Den svenske kungen hade tillbringat flera ir i dessa trakter nar han pi h6sten 1714 beslot att itervhnda till Sverige. Han startade iterfhrden frin en plats som ligger bara nigra mil frin Bukarest, Pitesti. Sedan red han genom hela Europa pi 15 dagar - en ganska imponerande fysisk prestation. Sveriges utrikespolitik idag ar mindre Hventyrlysten an pa Karl XII :s tid. Vi har inga maktpolitiska ambitioner. Tvartom, vi ar ett mycket fredligt folk. Det har vi varit
Performance Evaluation and Interpretation of Unfiltered Feher-Patented Quadrature-Phase-Shift Keying (FQPSK) (1999)

A new interpretation of unfiltered Feher-patented quadrature-phase-shift keying (FQPSK) is presented that readily identifies a means for spectral enhancement of the transmitted waveform as well as an improved method of reception. The key to these successes is the replacement of the half-symbol-by-half-symbol mapping originally used to describe FQPSK by a symbol-by-symbol mapping operation combined with memory. The advantages of such an interpretation are twofold. In particular, the original FQPSK scheme can be modified such that the potential of a waveform slope discontinuity at the boundary between half symbols is avoided without sacrificing the “constant” envelope property of the transmitted waveform, and, furthermore, a memory receiver can be employed to improve error-probability performance relative to previously proposed symbol-by-symbol detection methods. The analysis presented in this article does not include other versions of FQPSK such as FQPSK-B, which currently is being considered for military application.