gebhart/patrepeval huggingface dataset:
Enhancement of transport critical current densities at 75 K in (Bi,Pb)2Sr2Ca2Cu3O<i>y</i>/Ag tapes by means of fission tracks from irradiation by 0.8 GeV protons (1995)

The transport critical current density Jc of oxide-powder-in-tube mono- and multifilamentary Bi-2223/Ag tapes has been determined before and after irradiation by 0.8 GeV protons at fluences up to 7.0×1016 protons/cm2. Proton-induced fission of the Bi nuclei produced up to 8.6×1013 fissions/cm3, creating long tracks at densities equivalent to matching fields up to 1.1 T. Relative to unirradiated tapes, Jc values at 75 and 64 K show no decrease in self field, indicating no breakdown of intergranular coupling, and show large, dose-dependent enhancements in magnetic fields oriented parallel to the tape normal.
Combining color and geometry for the active, visual recognition of shadows (2002)

Shadows are a frequent occurrence, but they cannot be infallibly recognized until a scene's geometry and lighting are known. We present a number of cues which together strongly suggest the identification of a shadow and which can be examined with low cost. The techniques are: a color image segmentation method that recovers single material surfaces as single image regions irregardless of the surface partially in shadow, a method to recover the penumbra and umbra of shadow; a method for determining whether some object could be obstructing a light source. The last cue requires the examination of well understood shadows in the scene. Our observer is equipped with an extendable probe for casting its own shadows. Actively obtained shadows allow the observer to experimentally determine the location of the light sources in the scene. The system has been tested both indoors and out.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preparation and characterization of polylactic acid microspheres containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method (1996)

Polylactic acid (PLA) microspheres containing soluble dyes as water-soluble model compounds were prepared using the water-in-oil-in-water (w/o/w) emulsion solvent evaporation method. Addition of electrolytes such as NaCl or CaCl2 into the external aqueous phase significantly improved brilliant blue (BB) entrapment efficiency compared to the case of no additives. NaCl was the most effective for obtaining high entrapment efficiency (80-90% of theoretical BB content). The average diameter of the obtained microspheres was in the region of 10-20 microns in all cases. PLA microspheres containing 5 and 10% (w/w) BB exhibited the so-called burst release. The release rate decreased with decrease in the internal aqueous droplet volume in the preparation process. In particular, with PLA microspheres containing 5% (w/w) BB, those prepared with the smallest internal droplet volume (63 microliter), the initial burst release was reduced significantly, and 50% (w/w) of the loaded BB remained in the microspheres for 7 days.
Huperzine A attenuates apoptosis and mitochondria‐dependent caspase‐3 in rat cortical neurons (2002)

The neuroprotection of huperzine A against apoptosis was investigated. In cultures of rat primary cortical neurons, neuronal apoptosis was induced by serum deprivation for 24 h, which was accompanied by enhanced caspase-3 activity and the release of cytochrome c into the cytosol from mitochondria. Pretreating the neurons for 2 h with huperzine A (0.1-10 microM) improved neuronal survival. Huperzine A at a concentration of 1 microM significantly attenuated apoptosis by inhibiting the mitochondria-caspase pathway directly and indirectly.
A Unified Streaming Architecture for Real Time Face Detection and Gender Classification (2007)

An integral part of interactive computing environments are systems that have the ability to process information about their users in real-time. In many cases it is desirable to not only recognize a human user but also to extract as much information about the user as possible, such as gender, ethnicity, age, etc. In this paper we present an FPGA implementation of a neural network configured specifically for performing face detection and gender classification in real-time video streams. Our streaming architecture performs the face and gender classification tasks at 30 frames per second on a small sized Virtex-4 FPGA, at accuracy comparable to that of a leading commercial software implementation.
RhoA Silencing Reverts the Resistance to Doxorubicin in Human Colon Cancer Cells (2008)

The efficacy of doxorubicin in the treatment of cancer is limited by its side effects and by the onset of drug resistance. Reverting such resistance could allow the decrease of the dose necessary to eradicate the tumor, thus diminishing the toxicity of the drug. We transfected doxorubicin-sensitive (HT29) and doxorubicin-resistant (HT29-dx) human colon cancer cells with RhoA small interfering RNA. The subsequent decrease of RhoA protein was associated with the increased sensitivity to doxorubicin in HT29 cells and the complete reversion of doxorubicin resistance in HT29-dx cells. RhoA silencing increased the activation of the nuclear factor-kappaB pathway, inducing the transcription and the activity of nitric oxide synthase. This led to the tyrosine nitration of the multidrug resistance protein 3 transporter (MRP3) and contributed to a reduced doxorubicin efflux. Moreover, RhoA silencing decreased the ATPase activity of P-glycoprotein (Pgp) in HT29 and HT29-dx cells as a consequence of the reduced expression of Pgp. RhoA silencing, by acting as an upstream controller of both MRP3 nitration and Pgp expression, was effective to revert the toxicity and accumulation of doxorubicin in both HT29 and HT29-dx cells. Therefore, we suggest that inactivating RhoA has potential clinical applications and might in the future become part of a gene therapy protocol.
The permethylcyclosilanes (Me2Si)5 through (Me2Si)35 (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe permethylcyclosilanes (Me2Si)5 through (Me2Si)35Lawrence F. Brough and Robert WestCite this: J. Am. Chem. Soc. 1981, 103, 11, 3049–3056Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://doi.org/10.1021/ja00401a024RIGHTS & PERMISSIONSArticle Views235Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (690 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A Circularly Polarized Antenna With Wide Axial Ratio Beamwidth (2009)

A novel circularly polarized (CP) antenna with wide angular coverage is presented. The proposed antenna is formed by two bowtie patch antennas and two electric dipoles. It can achieve an impedance bandwidth (SWR < 1.6) of 41% and a 3-dB axial ratio bandwidth of 33%. For this design, very stable and symmetrical radiation patterns are obtained. In the axial ratio passband, the 3-dB beamwidth is 85 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">deg</sup> plusmn2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">deg</sup> with a gain of 6.3 dBi plusmn0.3 dBi. The cross polarization is lower than -15 dB over a wide range of angles. For the entire half-power beamwidth, the axial ratio can be kept below 3 dB.
[Localization diagnostics of malignant tumors using radioactive bleomycin (author's transl)]. (1977)

Total-body scintigraphy with 111In-labeled bleomycin was performed in 66 patients with malignant solid tumors and systemic diseases of the lymphatic pathways (Hodgkin's lymphoma and non-Hodgkin's lymphoma). In 38 (58%) of 66 cases positive information was correct. In 12 (18%) of 66, scintigraphic information was correctly negative. With 16 out of 66 (24%), false positive or false negative informations were obtained.
Measurement of Gilbert damping parameters in nanoscale CPP-GMR spin valves (2010)

In situ device-level measurement of thermal mag-noise spectral linewidths in 60 nm diameter current-perpendicular-to-plane--giant magnetoresistive spin-valve stacks of IrMn/ref/Cu/free, with reference and free layer of similar CoFe/CoFeGe alloy, are used to simultaneously determine the intrinsic Gilbert damping for both magnetic layers. It is shown that careful alignment at a ``magic angle'' between free- and reference-layer static equilibrium magnetization can allow direct measurement of the broadband intrinsic thermal spectra in the virtual absence of spin-torque effects which otherwise grossly distort the spectral line shapes and require linewidth extrapolations to zero current (which are nonetheless also shown to agree well with the direct method). The experimental magic-angle spectra are shown to be in good qualitative and quantitative agreement with both macrospin calculations and micromagnetic eigenmode analysis. Despite similar composition and thickness, it is repeatedly found that the IrMn exchange pinned reference layer has an order of magnitude larger intrinsic Gilbert damping $(\ensuremath{\alpha}\ensuremath{\approx}0.1)$ than that of the free layer $(\ensuremath{\alpha}\ensuremath{\approx}0.01)$. It is argued that the large reference-layer damping results from strong, off-resonant coupling to lossy modes of an IrMn/ref couple, rather than commonly invoked two-magnon processes.
Generalized Buckley–Leverett theory for two-phase flow in porous media (2011)

Hysteresis and fluid entrapment pose unresolved problems for the theory of flow in porous media. A generalized macroscopic mixture theory for immiscible two-phase displacement in porous media (Hilfer 2006b Phys. Rev. E 73 016307) has introduced percolating and nonpercolating phases. It is studied here in an analytically tractable hyperbolic limit. In this limit a fractional flow formulation exists, that resembles the traditional theory. The Riemann problem is solved analytically in one dimension by the method of characteristics. Initial and boundary value problems exhibit shocks and rarefaction waves similar to the traditional Buckley–Leverett theory. However, contrary to the traditional theory, the generalized theory permits simultaneous drainage and imbibition processes. Displacement processes involving flow reversal are equally allowed. Shock fronts and rarefaction waves in both directions in the percolating and the nonpercolating fluids are found, which can be compared directly to experiment.
Autonomous test scheme for analog ASICs (2002)

Analog autonomous test (AAT) is a structured design-for-testability methodology for mixed analog/digital ICs. By using analog switches and test-bus to gain controllability and observability, a chip is partitioned into testable submodules for production testing. Therefore, both test vector development period and production test time can be reduced.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Gratings in metrology (1972)

The uses of optical gratings in linear and radial measurement are reviewed historically. They are shown to involve a 'self-improving' principle which is applied to the generation of the gratings themselves and to the transducers used in reading them. Accurate automatic measurement is thus made available to a wide range of laboratory and engineering applications.
Hemodynamic forces in a model left ventricle (2016)

Modification of the forces due to abnormal motions of the wall are analyzed in a model left ventricle, showing that loss of temporal synchrony is more relevant than loss of spatial uniformity. A relatively simple integral model is then introduced, it is able to capture the main properties of the global hemodynamic force balance.
Phospholipases: Occurrence and production in microorganisms, assay for high‐throughput screening, and gene discovery from natural and man‐made diversity (2005)

Abstract Various kinds of phospholipids have wide industrial applications such as in food and nutraceuticals, cosmetics, agricultural products, and pharmaceuticals. The demand for reliable biocatalysts for the production of phospholipid products, such as phospholipases A 1 , A 2 , C, and D, has steadily increased over the past several decades. A large number of microbial phospholipases have been isolated and characterized, and the increasing availability of these enzymes could eventually lead to the sustained development of phospholipid‐related biotechnology. Although a number of reactions have been performed using phospholipases, a reliable and efficient supply of superior phospholipases in quantity is still a challenge for their practical application. High‐throughput functional assay methods for phospholipases should be devised to develop superior new species from the huge diversity of phospholipases. Recent biotechnological advances in the discovery of new phospholipase genes from natural sources, such as extremophiles of phospholipases by protein engineering, such as directed evolution, can provide valuable means of rapidly developing practical uses of phospholipases for various applications.
Synthesis and pregnancy terminating activity of 2-arylimidazo [2,1-a]isoquinolines and isoindoles. (1983)

A series of 2-arylimidazo[2,1-a]isoquinolines (1-21), some 5,6-dihydro derivatives (22-28) and 2-phenyl-5H-imidazol[2,1]isoindole (29) were synthesized and tested for the pregnancy terminating activity in hamsters and rats. An efficient preparation of 2-arylimidazo[2,1-a]isoquinolines was devised. The isoquinolines having a 4-chlorophenyl (8), 4-bromophenyl (9), or a biphenylyl group (12) in the 2-position were the most potent compounds after subcutaneous administration. Compound 12 also showed good oral activity. The data obtained with the title compounds are compared with those of the corresponding triazolo [5,1-1]isoquinolines and isoindoles. The structure-activity relationships are discussed.
Novel Effect of C75 on Carnitine Palmitoyltransferase I Activity and Palmitate Oxidation (2006)

C75 is a potential drug for the treatment of obesity. It was first identified as a competitive, irreversible inhibitor of fatty acid synthase (FAS). It has also been described as a malonyl-CoA analogue that antagonizes the allosteric inhibitory effect of malonyl-CoA on carnitine palmitoyltransferase I (CPT I), the main regulatory enzyme involved in fatty acid oxidation. On the basis of MALDI-TOF analysis, we now provide evidence that C75 can be transformed to its C75-CoA derivative. Unlike the activation produced by C75, the CoA derivative is a potent competitive inhibitor that binds tightly but reversibly to CPT I. IC50 values for yeast-overexpressed L- or M-CPT I isoforms, as well as for purified mitochondria from rat liver and muscle, were within the same range as those observed for etomoxiryl-CoA, a potent inhibitor of CPT I. When a pancreatic INS(823/13), muscle L6E9, or kidney HEK293 cell line was incubated directly with C75, fatty acid oxidation was inhibited. This suggests that C75 could be transformed in the cell to its C75-CoA derivative, inhibiting CPT I activity and consequently fatty acid oxidation. In vivo, a single intraperitoneal injection of C75 in mice produced short-term inhibition of CPT I activity in mitochondria from the liver, soleus, and pancreas, indicating that C75 could be transformed to its C75-CoA derivative in these tissues. Finally, in silico molecular docking studies showed that C75-CoA occupies the same pocket in CPT I as palmitoyl-CoA, suggesting an inhibiting mechanism based on mutual exclusion. Overall, our results describe a novel role for C75 in CPT I activity, highlighting the inhibitory effect of its C75-CoA derivative.
Analysis of estrogenic effects by quantification of green fluorescent protein in juvenile fish of a transgenic medaka (2005)

TheChgH-GFP strain of the teleost medaka contains a regulatory region of the estrogen-responsive choriogenin H (chgH) gene fussed to the green fluorescent protein (GFP) gene. The strain was developed for the identification of environmental estrogens by noninvasive analysis of GFP fluorescence. In the present study, a quantification method for GFP by image analysis was establishedand applied to the analysis of time- and concentration-dependent GFP fluorescence in juvenile fish. Concentration-response analyses were performed with fish exposed for 14 d to 17beta-estradiol (0.37-367 pM), genistein (0.37-367 nM), or p-nonylphenol (0.367-1,835 nM). By means of image analysis, it was shown that ChgH-GFP was induced at 183.5 pM or greater 17beta-estradiol. Time-course and recovery experiments indicated a strong accumulation of GFP in the liver. Results of reverse transcriptase-polymerase chain reaction analysis of choriogenin H and vitellogenin demonstrated induction of gene expression for the same rangeof concentrations as that for GFP analysis. Neither expression of these genes nor GFP fluorescence was induced by genistein and p-nonylphenol. Although the ChgH-GFP strain failed to detect these weakly estrogenic compounds, the simplicity of the GFP quantification during early life stages of fish offers promising possibilities for further developments of transgenic strains using different target regulatory sequences.
A Web-enabled Configuration System for Interior Design (2015)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
A chimeric tRNA(Lys3)-ribozyme inhibits HIV replication following virion assembly. (1995)

Co-localization of ribozymes with their appropriate target is one method utilized to increase their effectiveness in vivo. Effective antiviral ribozymes will likely rely on mechanisms which direct the ribozyme to the genomic or subgenomic RNAs. Exploiting the fact that a specific host cellular tRNA primer is bound by viral proteins and co-packaged with viral genomes in newly synthesized virions, ribozymes were fused to the 3'-terminus of tRNA(Lys3) in an attempt to direct their activity to cleave the HIV-1 genome. This chimeric ribozyme is catalytically active in vitro, and is efficiently recognized and bound by HIV-1 reverse transcriptase with affinities similar to tRNA(Lys3). The intragenic RNA polymerase III promoter entity of the tRNA allows for high levels of expression of the tRNA-RBZ and the preferential localization of transcript within the cytoplasm in transfected cells. This ribozyme was effective in reducing the infectivity of a viral stock which was produced from transiently transfected cells bearing the chimeric gene. These results demonstrate the feasibility of using tRNAs as a means of co-localizing ribozymes with their viral genomic RNA targets. The possibility exists to fuse stable RNAs to ribozymes as a means of increasing their stability and localizing them to their appropriate target sites.
Scheduling tool and algorithm for integrated modular avionics systems (2002)

As computer and software technologies have advanced, the approach of Integrated Modular Avionics (IMA) has emerged in the field of avionics systems. The IMA approach can dramatically reduce production and maintenance costs and increase reliability of these safety-critical real time systems. The IMA hardware and foundation software must be able to provide guarantees to the application software so that the real-time constraints of all applications are simultaneously satisfied. In addition, each application must be protected from interference by other applications and the operating system software must itself be protected while physically sharing resources such as processors and communication hardware and busses. In other words, an IMA implementation requires that the concepts of spatial and temporal partitioning are provided and guaranteed. This paper introduces a scheduling tool and its algorithms that can be used to solve the fundamental temporal partitioning problems together with implementation related practical constraints. Based on the two-level scheduling hierarchy architecture of ARINC IMA standards, we model an IMA system composed of multiple partition servers and channel servers. A partition server models a protected application that may be composed of multiple concurrent tasks. A channel server provides temporally and spatially protected message transmission among applications. The ultimate objective of the tool is to provide schedules for both tasks and messages that provide for robust temporal partitioning.
Spectrum Sharing by Adaptive Transmit Power Control for Low Priority Systems and Achievable Capacity (2009)

A spectrum sharing method is proposed for systems that share the same frequency band or adjacent bands with services that have different priorities. The proposed method adaptively controls transmission power according to information provided by the high-priority system receivers. We give the theoretical capacities achieved by low-priority systems when the proposed method and a conventional method (constant transmit power) are applied. Numerical results confirm that the proposed method attains 1.5-2 times larger capacity than the conventional method.
Minimizing inductive noise in system-on-a-chip with multiple power gating structures (2004)

A multiple power domain strategy in which each power domain has an independent power gating structure is an effective means for reducing leakage power consumption in a system-on-a-chip. During an individual power gating structure power-mode transition, however, serious inductive noise is introduced that may affect normal operation of neighboring circuits. We present a novel power gating structure in which inductive noise is reduced through gradual turn-on and turn-off its sleep transistor. Experimental simulation results with PowerSpice fixtured in different package models demonstrate the effectiveness of the proposed power gate switching noise reduction technique.
A Rapid Protein Test for Acoustic Neurinoma (1972)

Perilymph protein was found to be elevated over 1,000 mg/100 ml in 53 patients with acoustic neurinoma. A simple rapid microprotein test for inner ear fluid has been developed that can be used by the otologic surgeon in the operating room. This test requires 1.5μl of inner ear fluid, which is collected from the vestibular cistern in micropipets by capillary attraction. The rapid protein test has been used successfully in 15 patients and appears to be satisfactory as a method of determining approximate inner ear fluid protein concentrations.