gebhart/patrepeval huggingface dataset:
An optical-fibre refractometric liquid-level sensor for liquid nitrogen (2006)

This paper presents a prototype optical-fibre refractometric liquid-level sensor which can access the static and dynamic levels of liquid nitrogen in large cryogenic systems. This version of the sensor is intended for use in various tests of cryogenic systems such as used in rocketry, during the design stage. The sensor employs a vertical linear array of 140 highly sensitive optical-fibre refractometric transducers. The liquid-level measurement range is 1.6 m with a resolution of up to 5 mm. The optical transducers are multiplexed using a matrix-type optical-fibre network which employs a robust level tracking algorithm. This type of sensor can be used for measuring the level of other cryogenic liquids such as liquid hydrogen.
Voltage dependence of hard breakdown growth and the reliability implication in thin dielectrics (2002)

Hard breakdown (HBD) is shown to be a gradual process with the gate current increasing at a predictable rate exponentially dependent on the instantaneous stress voltage and oxide thickness. This is contrary to conventional wisdom that maintains that HBD is a fast thermally driven process. The HBD degradation rate (DR) for a 15 /spl Aring/ oxide scales from >1 mA/s at 4 V to <1 nA/s at 2 V, extrapolating to <10 fA/s at use voltage. Adding the HBD evolution time to the standard time-to-breakdown potentially reduces the projected fail rate of gate dielectrics by orders of magnitude.
Role of Ca2+ channel in cardiac excitation‐contraction coupling in the rat: evidence from Ca2+ transients and contraction. (1991)

1. Optical methods were used to measure simultaneously unloaded cell shortening and intracellular Ca2+ transients in whole-cell voltage clamped rat ventricular myocytes. Red light (greater than 670 nm) was used to measure cell shortening with a linear photodiode array. The dyes Fura-2 (Kd = 140 nM) and Mag-Fura-2 (Kd = 44 microM) were used as Ca2+ indicators with fluorescence excitation at 340 and 410 nm and emission at 510 nm. 2. Repeated measurements at 6 s intervals as 0.4 mM-Fura-2 diffused into the cell from the tip of the voltage clamp pipette showed no decrease in the rate of rise and peak value of the intracellular Ca2+ transient and only a small suppression of cell shortening, suggesting that the molecular mechanisms regulating the Ca2+ release were not significantly altered by the buffering capacity of the Fura-2. 3. Experiments in which the sarcoplasmic reticulum (SR) was depleted of Ca2+ either by exposure to caffeine or by repeated brief (20 ms) voltage clamp depolarizations confirm that the SR is the major source of activator Ca2+. 4. Mag-Fura-2 (1 or 5 mM) was used to register the initial rapid development of the [Ca2+]i transient but the later time course of the Ca2+ transients measured with this dye was obscured by motion artifacts resulting from cell shortening. 5. Both Fura-2 and Mag-Fura-2 showed that depolarization to 0 mV from a holding potential of -80 mV resulted in a [Ca2+]i transient which developed with a delay of 3-9 ms and approached its peak value in an additional 8-19 ms. Both Ca2+ indicators also showed that the Ca2+ transient approached its peak value more slowly as the clamped membrane potential was made increasingly more positive. 6. The voltage dependencies of the Ca2+ signal (Fura-2) and cell shortening were both bell-shaped and were qualitatively similar to the voltage dependence of Ca2+ current simultaneously measured. This was observed with holding potentials of both -40 and -80 mV. 7. Comparison of the temporal relation of the Ca2+ current, ICa, and intracellular Ca2+ transient (Fura-2) and cell shortening at different membrane potentials showed that Ca2+ transient measured 25 ms into the depolarization correlated closely to the integral of the Ca2+ current measured prior to this time. Cell shortening, on the other hand, peaked about 100 ms later and correlated with measurements of the Ca2+ activity at the later time.(ABSTRACT TRUNCATED AT 400 WORDS)
Review on Graphite Foam as Thermal Material for Heat Exchangers (2011)

Due to the increased power consumptions in equipment, the demand of effective cooling methods becomes crucial. Because of the small scale spherical pores, graphite foam has huge specific surface area. Furthermore, the thermal conductivity of graphite foam is four times that of copper. The density of graphite foam is only 20 % of that of aluminum. Thus, the graphite foam is considered as a novel highly -conductive porous material for high power equipment cooling applications. However, in the commercial market, aluminum and copper are still the preferred materials for thermal management nowadays. In order to promote the graphite foam as a thermal material for heat exchangers, an overall understanding of the graphite foam is needed. This paper describes the structure of the graphite foam. Based on the special structure, the thermal properties and the flowing characteristics of graphite foam are outlined and discussed. Furthermore, the application of graphite foam as a thermal material for heat exchangers is highlighted for electronic packages and vehicle cooling systems. The physical problems and other aspects, which might block the development of graphite foam heat exchangers, are pointed out. Finally, several useful conclusions and suggestions are given to promote the development of graphite foam heat exchangers.
Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster (2008)

Mitochondrial DNA (mtDNA) variants are widely used in evolutionary genetics as markers for population history and to estimate divergence times among taxa. Inferences of species history are generally based on phylogenetic comparisons, which assume that molecular evolution is clock-like. Between-species comparisons have also been used to estimate the mutation rate, using sites that are thought to evolve neutrally. We directly estimated the mtDNA mutation rate by scanning the mitochondrial genome of Drosophila melanogaster lines that had undergone approximately 200 generations of spontaneous mutation accumulation (MA). We detected a total of 28 point mutations and eight insertion-deletion (indel) mutations, yielding an estimate for the single-nucleotide mutation rate of 6.2 x 10(-8) per site per fly generation. Most mutations were heteroplasmic within a line, and their frequency distribution suggests that the effective number of mitochondrial genomes transmitted per female per generation is about 30. We observed repeated occurrences of some indel mutations, suggesting that indel mutational hotspots are common. Among the point mutations, there is a large excess of G-->A mutations on the major strand (the sense strand for the majority of mitochondrial genes). These mutations tend to occur at nonsynonymous sites of protein-coding genes, and they are expected to be deleterious, so do not become fixed between species. The overall mtDNA mutation rate per base pair per fly generation in Drosophila is estimated to be about 10x higher than the nuclear mutation rate, but the mitochondrial major strand G-->A mutation rate is about 70x higher than the nuclear rate. Silent sites are substantially more strongly biased towards A and T than nonsynonymous sites, consistent with the extreme mutation bias towards A+T. Strand-asymmetric mutation bias, coupled with selection to maintain specific nonsynonymous bases, therefore provides an explanation for the extreme base composition of the mitochondrial genome of Drosophila.
Resistance to Experimental Autoimmune Myasthenia Gravis in IL-6-Deficient Mice Is Associated with Reduced Germinal Center Formation and C3 Production (2002)

To provide direct genetic evidence for a role of IL-6 in experimental autoimmune myasthenia gravis (EAMG), IL-6 gene KO (IL-6(-/-)) mice in the C57BL/6 background were immunized with Torpedo californica acetylcholine receptor (AChR) and evaluated for EAMG. Only 25% of AChR-immunized IL-6(-/-) mice developed clinical EAMG compared to 83% of C57BL/6 (wild-type) mice. A significant reduction in the secondary anti-AChR Ab of IgG, IgG(2b), and IgG(2c), but not the primary or secondary IgM response was observed in AChR-immunized IL-6(-/-) mice, suggesting a possible defect in T cell help and class switching to anti-AChR IgG(2) isotype. The AChR-specific lymphocyte proliferative response, IFN-gamma, and IL-10 production were suppressed in AChR-immunized IL-6(-/-) mice. EAMG resistance in IL-6(-/-) mice was associated with a significant reduction in germinal center formation and decreased serum complement C3 levels. The data provide the first direct genetic evidence for a key role of IL-6 in the autoimmune response to AChR and in EAMG pathogenesis.
Direct C–H bond arylation of arenes with aryltin reagents catalysed by palladium complexes (2008)

Direct C-H bond arylation of simple arenes with aryltin reagents has been successfully catalysed by PdCl2 in the presence of CuCl2. CuCl2 proved to be an activator for a palladium intermediate as well as an oxidant.
Serosal mesothelium retains vasculogenic potential (2007)

Mesothelia comprise the epithelial covering of coelomic organs and line the cavities in which they are housed. Mesothelia contribute to the vasculature of the heart and the intestinal tract by developmental processes of epithelial-mesenchymal transition (EMT), migration, and differentiation into endothelial cells, vascular smooth muscle cells, and pericytes. Here, we establish a novel in vitro system to analyze the differentiative potential of mesothelia. Using explants from serosal mesothelium (the mesothelial covering of the gut), we demonstrate that much of the developmental program observed in embryonic mesothelia is retained in the adult structure. Namely, processes of epithelial spreading, EMT, and differentiation into smooth muscle cells from these cells are observed. Interestingly, we were unable to stimulate endothelial cell differentiation using serum or various signaling factors. Taken together, these data reveal that differentiated serosal cells retain vasculogenic potential and provide a generalizable model for future studies on the developmental and differentiative capacity of the mesothelial cell type.
Isolation of viral haemorrhagic septicaemia virus from mummichog, stickleback, striped bass and brown trout in eastern Canada (2007)

Viral haemorrhagic septicaemia virus (VHSV) was isolated from mortalities occurring in populations of mummichog, Fundulus heteroclitus, stickleback, Gasterosteus aculeatus aculeatus, brown trout, Salmo trutta, and striped bass, Morone saxatilis, in New Brunswick and Nova Scotia, Canada. The isolated viral strains produced a cytopathic effect on the epithelioma papillosum cyprini cell line. Serum neutralization indicated the virus was VHSV and sequencing identified the rhabdovirus isolates as the North American strain of VHSV. Phylogenetic analysis indicated that the isolates are closely related and form a distinguishable subgroup of North American type VHSV. To our knowledge, this is the first report of VHSV in mummichog and striped bass.
A generalised model for utilising prosodic information in continuous speech recognition (2002)

Prosodic features in continuous speech provide cues which may be used to disambiguate syntactic ambiguities and to increase the accuracy of speech recognition/understanding systems. This paper presents a novel method using a multivariate statistical framework for producing a model of the relationship between prosodic and syntactic structures in continuous speech. The model can be used for Linguistic/Phonetic research and in speech synthesis. This paper concentrates on its use for integrating prosodic information into a continuous speech recognition system. The model can produce a relative probability score for the conformance of the prosodic and syntactic structures of hypothesised sentences for an existing word recognition system and achieves 73% accuracy in disambiguating structurally ambiguous sentences.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Protective vaccination with hepatitis C virus NS3 but not core antigen in a novel mouse challenge model (2007)

Our data suggest that the challenge system using recombinant MHV-68 is a highly suitable model to test the immunogenicity and protective capacity of HCV candidate vaccine antigens. Using this system, we demonstrated the usefulness of NS3-specific immunization. By contrast, our analysis rather discarded core as a vaccine antigen.
Issues in the assessment and treatment of male sex offenders with mild learning disabilities (1993)

Abstract The psychological assessment and treatment of male sex offenders has been of increasing interest in recent years, and a substantial literature, primarily cognitive-behavioural in orientation, now exists. However, there is little information about the application of this literature to men with mild learning disabilities (previously known as mild ‘mental handicap’), who have impaired intellectual and social functioning and are at increased risk of additional difficulties. This paper uses the cognitive-behavioural approach as a framework for presenting preliminary guidance on the assessment and treatment of men with mild learning disabilities. It should be emphasized that, at present, almost nothing is known about the outcome of attempts to intervene in the sex offending of this population.
Construction Projects Immediate Health Check: A CSF & KPI Approach (2004)

Many factors have the potential to influence human health. These factors need to be monitored to maintain health. As is the case with human health, construction projects have a number of critical factors that can facilitate a broad evaluation of project health. In order to use these factors as an indication of health, they need to be assessed. This assessment can help to achieve desired outcomes for the project. This paper discusses the approach of assessing Critical Success Factors (CSFs) using Key Performance Indicators (KPIs) to ascertain the immediate health of a construction project. This approach is applicable to all phases of construction projects and many construction procurement methods. KPIs have been benchmarked on the basis of industry standards and historical data. The robustness of the KPIs to assess the immediate health of a project has been validated using Australian and international case studies.
An Extract of Pomegranate Fruit and Galangal Rhizome Increases the Numbers of Motile Sperm: A Prospective, Randomised, Controlled, Double-Blinded Trial (2014)

ClinicalTrials.gov NCT01357044.
Dehydrobenzol und <i>N</i>‐Methyl‐pyrrol (1958)

Abstract In Fortführung der Untersuchungen über die dienophilen Eigenschaften von Dehydrobenzol wurde dieses mit N ‐Methyl‐pyrrol in Reaktion gebracht, wobei die aus einer 1.4‐Addition hervorgehenden Verbindungen VI und VII als Haupt‐produkte zu isolieren waren. Ihr Entstehungschemismus wird diskutiert und zum Schluß auf die Bedeutung des H OFMANN ‐Abbaus bei endo ‐Ammonium‐hydroxyden hingewiesen.
Experimental Assessment of PV Panels Front Water Cooling Strategy (2017)

The electrical performance and reliability of flat type photovoltaic (PV) modules can be severely affected by elevated cell operating temperature due to elevated ambient temperatures. In this work the free flow front water cooling solutions to enhance flat-type PV module electrical performance is experimentally explored on laboratory scale module operated outdoors under natural light luminance. Water-cooling is implemented using a perforated tube disposed on the top of the panel and a chilled water source, both attached to the module active surface. The cooling water directly wets the module active surface, thereby decreasing the light reflection loss and cleaning the panel surface in the same time. For given meteorological conditions, the efficiency of free water cooling was measured and the corresponding additionally electrical energy yield was determined. The equivalent electric circuit of the PV panel cooling system is developed and an appropriate algorithm for its parameters experimental determination is proposed.
Opening New Gates for the Modification of PVC or Other PVC Derivatives: Synthetic Strategies for the Covalent Binding of Molecules to PVC (2016)

Several synthetic strategies based on the use of substituted aromatic and hetero-aromatic thiols for the covalent binding of modifier compounds to PVC are described. A variety of aliphatic alcohols and amines are linked to the aromatic or heteroaromatic rings via highly active functionalities as the isocyanate, acidchloride, or chlorosulfonyl group, and the three chlorine atoms of trichlorotriazine. The first three pathways lead to protected aromatic disulfides obtaining the substituted aromatic thiols by reduction as a final step of an unprecedented synthetic route. The second approach, in a novel, extremely efficient, and scalable process, uses the particular selectivity of trichlorotriazine to connect aliphatic amines, alcohols, and thiols to the ring and creates the thiol via nucleophilic substitution of a heteroaromatic halogen by thiourea and subsequent hydrolysis. Most of the modifier compounds were linked to the polymer chains with high degrees of anchorage. The presented approaches are highly versatile as different activations of aromatic and heteroaromatic rings are used. Therefore, many types of tailored functional nucleophiles may be anchored to PVC providing non-migrating materials with a broad range of applications and properties.
Cell surface transport, oligomerization, and endocytosis of chimeric type II glycoproteins: role of cytoplasmic and anchor domains. (1991)

We investigated the role of cytoplasmic and anchor domains of type II glycoproteins in intracellular transport, oligomerization, and endocytosis by expressing the wild-type and chimeric genes in mammalian cells. Chimeric genes were constructed by exchanging the DNA segments that encode the cytoplasmic and anchor domains between the human influenza virus (A/WSN/33) neuraminidase (NA) and transferrin receptor (TR). The chimeric proteins in which domains were exchanged precisely were productively targeted to the cell surface. However, the proteins appeared to assemble differently in the intracellular compartment. For example, while TR existed predominantly as a dimer, NATR delta 90, containing the cytoplasmic and signal-anchor domains of NA and the ectodomain of TR, was present as a tetramer, a dimer, and a monomer. Similarly, the influenza virus NA existed predominantly as a tetramer but TRNA delta 35, in which the cytoplasmic and signal-anchor domains of TR were joined to the ectodomain of NA, existed predominantly as a dimer, suggesting that the cytoplasmic and anchor domains of type II glycoproteins affect the subunit assembly of heterologous ectodomains. In addition, we analyzed the role of the cytoplasmic domain in endocytosis. NA and NATR delta 90 did not undergo endocytosis, whereas both TR and TRNA delta 35 were internalized efficiently, demonstrating that the NH2 cytoplasmic domain of TR was capable of internalizing a heterologous ectodomain (NA) from the cell surface.
Isothiazoles. Part XI. Carbinols, aryl ketones, and aminomethyl derivatives of isothiazoles (1968)

Previous work on aryl and hydroxymethyl isothiazoles has been extended and some aroyl isothiazoles and the corresponding secondary alcohols have been prepared. Primary alcohols were obtained by reduction of the known formyl compounds, and secondary alcohols by reactions of Grignard or lithium derivatives with aldehydes.Aroyl derivatives were prepared by lithium or Grignard reactions from the appropriate nitriles, acid chlorides, or acyl imidazoles, or by oxidation of the secondary alcohols referred to above.The alcohols were converted by reaction of the corresponding chloro-compounds with amines into aminomethylisothiazoles of potential pharmacological interest. The latter were also prepared in some cases by reduction of the Schiff bases of isothiazole aldehydes.
Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes (2010)

Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or reoxygenated A431 carcinoma cells exhibited enhanced angiogenic and metastatic potential such as reduced cell-cell and cell-extracellular matrix adhesion, increased invasiveness, and production of a secretion with increased chorioallantoic membrane angiogenic activity. Consistent with these observations, quantitative proteomics revealed that under hypoxia the tumor cells secreted proteins involved in angiogenesis, focal adhesion, extracellular matrix-receptor interaction, and immune cell recruitment. Unexpectedly, the secreted proteins were predominantly cytoplasmic and membrane proteins. Ultracentrifugation at 100,000 x g precipitated 54% of the secreted proteins and enriched for many exosome-associated proteins such as the tetraspanins and Alix and also proteins with the potential to facilitate angiogenesis and metastasis. Two tetraspanins, CD9 and CD81, co-immunoprecipitated. Together, these data suggested that tumor cells secrete proteins and exosomes with the potential to modulate their microenvironment and facilitate angiogenesis and metastasis.
A Four-Phase Chemical/Gas Model in an Implicit-Pressure/Explicit-Concentration Reservoir Simulator (2016)

Summary This study describes a general four-phase model developed for gas/oil/water/microemulsion (ME) coexisting at local equilibrium. The original framework of a chemical reservoir simulator is used to implement the model. This model represents a new method to couple the black-oil model with surfactant-phase behavior [i.e., the Hand (1939) rule]. The Hand (1939) rule is used to capture the equilibrium among surfactant, oil, and water species as a function of salinity and species concentrations for oil/water/ME phases. The interphase-mass transfer between gas/oil in the presence of the ME phase is calculated at the equilibrium between phases. For this purpose, a new volume-balance equation is derived to consider the pressure equation for compressible and real mixing in such a model. Hence, the pressure equation is derived by extending the black-oil model to a pseudocompositional model for a wide range of components (water, oil, surfactant, polymer, anion, cation, alcohol, and gas). Mass-balance equations are then solved for the components to calculate the concentration. Finally, we implemented the coupled surfactant and black-oil phase-behavior models and the fluid-flow formulations in an implicit-pressure/explicit-concentration (IMPEC) chemical-flooding simulator: UTCHEM (2011) four-phase. The results were verified against existing reservoir simulators for two different three-phase test cases comprising gas/oil/water and oil/water/ME. Then, the performance of the model in the presence of four phases was tested and validated against coreflood experimental data. The results showed that the new phase behavior and the fluid-flow equations are consistent with three-phase reservoir simulators for the case studies. In addition, the findings of this work can be used to model and capture the mechanisms behind processes such as micellar slug foam and alkaline and surfactant flooding into saturated (gas cap) reservoirs as well as alternating or coinjection of surfactant and gas processes. Modeling of such processes is far from satisfactory in existing phase behavior and fluid-flow simulators.