gebhart/patrepeval huggingface dataset:
Asymptotic analysis of multistage cooperative broadcast in wireless networks (2006)

Cooperative broadcast aims to deliver a source message to a locally connected network by means of collaborating nodes. In traditional architectures, node cooperation has been at the network layer. Recently, physical layer cooperative schemes have been shown to offer several advantages over the network layer approaches. This form of cooperation employs distributed transmission resources at the physical layer as a single radio with spatial diversity. In decentralized cooperation schemes, collaborating nodes make transmission decisions based on the quality of the received signal, which is the only parameter available locally. In this case, critical parameters that influence the broadcast performance include the source/relay transmission powers and the decoding threshold (the minimum signal-to-noise ratio (SNR) required to decode a transmission). We study the effect of these parameters on the number of nodes reached by cooperative broadcast. In particular, we show that there exists a phase transition in the network behavior: if the decoding threshold is below a critical value, the message is delivered to the whole network. Otherwise, only a fraction of the nodes is reached, which is proportional to the source transmit power. Our approach is based on the idea of continuum approximation, which yields closed-form expressions that are accurate when the network density is high.
Influence of hemolysis on routine clinical chemistry testing (2006)

If hemolysis and blood cell lysis result from an in vitro cause, we suggest that the most convenient corrective solution might be quantification of free hemoglobin, alerting the clinicians and sample recollection.
Medical technology transfer: the inventor's perspective. (1991)

Technology transfer can be a difficult and frustrating experience for an inventor, one with a questionable outcome despite tremendous effort. A university-based inventor may find that there is a "technology transfer office" at his or her institution, but that it is poorly equipped to patent and license inventions. In such a case, the inventor may have to play a particularly active role in the patenting process and, especially, the marketing process. Furthermore, university-based inventors may find themselves caught up in issues of academic freedom and potential conflicts of interests. There are often no role models for entrepreneurial activity at a university, and as a result many inventors have had to leave their university positions to pursue financial gain from their inventions. When licensing inventions to companies, the "NIH syndrome" can be extremely frustrating. It is often difficult for the inventor to communicate his or her certain knowledge that the invention solves a specific problem perfectly. Also, an inventor may find that even if a company is interested and wishes to license the invention it may ultimately have little or no competence in the subject area and, as a result, the invention never finds its way to commercial production. Nonetheless, the rewards can be well worth the effort. If a successful license is reached and the device goes into production, there may be substantial personal financial reward for the inventor. If the university's patent policy is enlightened, a portion of the royalty income may support ongoing and future activities in the inventor's research laboratory.(ABSTRACT TRUNCATED AT 250 WORDS)
Fabrication of cellular poly-/spl isin/-caprolactone (PCL) scaffolds by precision extruding deposition process (2003)

Many applications in tissue engineering require scaffolds with specific micro- and macroscopic geometries and internal architectures in order to provide desirable biological and biophysical functions for intended tissue. Freeform fabrication has often been used as an effective process to produce such required scaffolds with designed structures and properties. This paper reports our study on exploring a novel precision extruding deposition (PED) method to directly fabricate cellular-like poly-/spl isin/-caprolactone (PCL) scaffolds. Scaffolds with designed pore size at about 250 /spl mu/m and at different strut orientations were fabricated. Results of the fabrication and the SEM optical micrographics evaluation for the structural formability and process-ability of as-fabricated scaffolds are presented.
High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing (2017)

Bioprinting is an emerging technique for the fabrication of living tissues that allows cells to be arranged in predetermined three-dimensional (3D) architectures. However, to date, there are limited examples of bioprinted constructs containing multiple cell types patterned at high-resolution. Here we present a low-cost process that employs 3D printing of aqueous droplets containing mammalian cells to produce robust, patterned constructs in oil, which were reproducibly transferred to culture medium. Human embryonic kidney (HEK) cells and ovine mesenchymal stem cells (oMSCs) were printed at tissue-relevant densities (10<sup>7</sup> cells mL<sup>-1</sup>) and a high droplet resolution of 1 nL. High-resolution 3D geometries were printed with features of ≤200 μm; these included an arborised cell junction, a diagonal-plane junction and an osteochondral interface. The printed cells showed high viability (90% on average) and HEK cells within the printed structures were shown to proliferate under culture conditions. Significantly, a five-week tissue engineering study demonstrated that printed oMSCs could be differentiated down the chondrogenic lineage to generate cartilage-like structures containing type II collagen.
Ventricular expression of brain natriuretic peptide in hypertrophic cardiomyopathy. (1993)

These findings suggest that BNP is expressed in the ventricular myocytes of HCM with normal systolic function. In HOCM, ventricular expression of BNP may be augmented in response to both obstruction and diastolic dysfunction.
U.S. Grain Exports and the Value of the Dollar (1987)

This article exammes the changes in grain exports from 1973 to 1985 A stmpltfied three-country trade model is introduced as a framework for analyzing U S gram trade, world gram trade, and market price when changes in two real effective exchange rates occur an exchange rate based on US trade with grain importers and an exchange rate based on global trade of grain competitors Although collitnearty in the data series makes implementatton of the theoretical model difficult, evidence suggests that the cumulative effect of a 1-percent depreciation (appreciation) in the value of the dollar was to expand (contract) U S wheat exports in the range of 2 3 percent and to expand feed grain exports in the range of 14 percent Wheat exports have adjusted to real exchange rate changes only over a long period of 10 -12 quarters Feed grain exports have been quicker to adjust to real exchange rate changes, but there are itgnificant lagged effects
TETRACYCLIC TRITERPENE ACIDS FROM RESIN OF BOSWELLIA-SERRATA ROXB (2011)

Four tetracyclic triterpene acids have been isolated from the resin of Boswellia serrata . On the basis of spectral considerations and simple interconversions, together with data described in the literature, the acids are shown to be 3-a-acetoxyutirucall-8,24-dien-21-oic acid (IVa), 3-ketotirucall-8,24-dien-21-oic acid (Ia), 3- -hydroxytirucall-8,24-dien-21-oic acid (IIa) and 3- -hydroxytirucall-8,24-dien-21-otc acid (IIIa).
Reactions of nitriles. Part VIII. Synthesis of 2,3-dihydroquinolin-4(1H)-ones (1972)

Cyanoethylation of several substituted anilines has been investigated. The resulting nitriles were hydrolysed to the corresponding acids, which on cyclisation afforded 2,3-dihydroquinolin-4(1H)-ones, whose structures were established on the basis of their spectra.
Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice (2005)

Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or without impairment of COX-2) and the interaction between COX and NOS isoforms during healing are less clear. Thus we investigated healing and regulation of COX and NOS isoforms during ulcer healing in COX-1 and COX-2 deficiency and inhibition mouse models. In this study, female wild-type COX-1(-/-) and COX-2(-/-) mice with gastric ulcers induced by cryoprobe were treated intragastrically with vehicle, selective COX-1 (SC-560), COX-2 (celecoxib, rofecoxib, and valdedoxib), and unselective COX (piroxicam) inhibitors. Ulcer healing parameters, mRNA expression, and activity of COX and NOS were quantified. Gene disruption or inhibition of COX-1 did not impair ulcer healing. In contrast, COX-2 gene disruption and COX-2 inhibitors moderately impaired wound healing. More severe healing impairment was found in dual (SC-560 + rofecoxib) and unselective (piroxicam) COX inhibition and combined COX impairment (in COX-1(-/-) mice with COX-2 inhibition and COX-2(-/-) mice with COX-1 inhibition). In the ulcerated repair tissue, COX-2 mRNA in COX-1(-/-) mice, COX-1 mRNA in COX-2(-/-) mice, and, remarkably, NOS-2 and NOS-3 mRNA in COX-impaired mice were more upregulated than in wild-type mice. This study demonstrates that COX-2 is a key mediator in gastric wound healing. In contrast, COX-1 has no significant role in healing when COX-2 is unimpaired but becomes important when COX-2 is impaired. As counterregulatory mechanisms, mRNA of COX and NOS isoforms were increased during healing in COX-impaired mice.
Modeling of NBTI-recovery effects in analog CMOS circuits (2013)

In addition to the well-known longtime degradation of CMOS circuits by Bias Temperature Instability (BTI) degradation, short stress pulses and subsequent recovery of parameter shifts can cause inaccurate transient response in CMOS circuits. Aging simulations to detect such failures in analog circuits like comparators and analog-to-digital converters require implementation of an analytic BTI model, as ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> -shifts and recovery effects have to be analyzed in every simulation time step. Therefore, we developed a simulation model for NBTI degradation including its recovery effects and an implementation of this NBTI model in a SPICE environment. With this toolset, a fast characterization of different circuit topologies is possible. The simulation model covers both DC- and AC-stress. The model is applied to analyze a comparator in switched-capacitor technique. In spite of offset compensation by auto-zeroing, it shows erroneous behavior due to the fast recovering part of the ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> shift.
Impedimetric Immunosensor Based on a Polypyrrole−Antibiotic Model Film for the Label-Free Picomolar Detection of Ciprofloxacin (2009)

This paper describes the construction of an impedimetric immunosensor for the label-free detection of ciprofloxacin, an antibiotic belonging to synthetic fluoroquinolones. A poly(pyrrole-N-hydroxysuccinimide) film was electrogenerated onto electrodes and then used for the reagentless covalent binding of a fluoroquinolone model bearing an amino group. The resulting electrodes were utilized to immobilize a layer of anticiprofloxacin antibody onto the polymer surface by immunoreaction. In presence of ciprofloxacin, the antibody was displaced in solution inducing marked changes in the impedance of the sensor electrodes. These phenomena were detected and characterized by electrochemical impedance spectroscopy allowing the selective detection of extremely low ciprofloxacin concentration, namely, 1 x 10(-12) g mL(-1) or 3 pmol L(-1). Sensors exposed to ciprofloxacin showed a decrease in the sum of the interfacial resistances with the increase in ciprofloxacin concentration from 1 x 10(-12) to 1 x 10(-6) g mL(-1).
Immunopathologic Characterization of a Monoclonal Antibody that Recognizes Common Surface Antigens of Human Ovarian Tumors of Serous, Endometrioid, and Clear Cell Types (1983)

A murine monoclonal antibody, OC125, reacts with a surface component of ovarian tumor cells from humans, but fails to react with normal adult ovarian cells. The spectrum of reactivity of OC125 in ovarian tumors from humans was defined by testing cryostat tissue sections from 60 selected ovarian tumors by indirect immunofluorescence. OC125 stained 7/7 benign, and borderline serous ovarian tumors, 19/23 (83%) serous adenocarcinomas, 2/2 mixed serous and endometrioid carcinomas, 2/3 endometrioid carcinomas, 1/4 clear cell carcinomas, and 2/2 undifferentiated carcinomas. No reactivity was found in eight mucinous ovarian tumors or any of the other 11 epithelial sex cord, germ cell, on hematopoietic tumors tested. In neoplastic cysts, papillae, and glands, the staining was most intense on the luminal surface or in subjacent cytoplasm. Cells in solid sheets also showed peripheral staining. Within a reactive tumor, both negative and positive cells could be found, intimately intermixed. There were no differences in these staining patterns between tissues from primary and metastatic sites. The expression of the OC125 antigen was not related to the degree of malignancy as judged by pathologic criteria. Although mucinous tumors lacked reactivity with OC125, seven of eight mucinous adenomas and adenocarcinomas bound a monoclonal antibody against carcinoembryonic antigen (CEA). Thus, OC125 recognizes a common antigen in some but not all ovarian tumors of serous, clear cell, endometrioid, or undifferentiated type. OC125 may prove useful in the pathologic and cytologic identification of certain types of ovarian tumor cells. Its lack of reactivity with mucinous tumors suggests these belong in a distinct subgroup of ovarian epithelial tumors.
Finfet with isolated U+ and p+ gate regions strapped with Metal and Polysilicon (2003)

A vertical double Gate MOSFET structure with a new gate stack architecture has been demonstrated. The Gate stack consists of two isolated polysilicon regions that are doped N+ and P+ with a metal/polysilicon strap connecting the doped regions. The device has an undoped channel yet performs as an enhancement mode MOSFET due to the asymmetric doping of the gate regions on either side of the channel. The advantages of this structure include: 1) reduction of the Vt variations caused by dopant fluctuation in the channel region 2) enhanced mobility due to an undoped channel region 3) flexibility to adjust Vt across a wide range from depletion mode to very high Vt depending on the application 4) lower interconnect resistance due to the use of metal/polysilicon gate components 5) better manufacturability due to easier patterning of gate over spacer. The devices are enhancement mode with Vt -= (0.1-0.3V) at lOOnm gate length and channel thickness of less than 30nm and height lOOnm tall have been demonstrated. Functional devices at the IOOnm gate have Ion =I91 pVpn , Vt = 0.3V Ioff = 0.5 pAl pm SS=94 mvidecade.. A different device with different implant dose and drive demonstrated Vt = 0.15V and SS=SOmV/decade at Lgate4.25pn
The Joint Experiment Center For Water Purification on take Biwa and Yodo River (1995)

Lake Biwa and Yodo River system has serious water quality problem which can not easily solved by only wastewater processing and discharge requirement, therefore research and development into technique for water purification of lakes and rivers are important subject. Now, the Ministry of Construction, the prefectures concerned and Water resource development public corporation are fully equipping the joint experiment center for water purification located on the shore of south Lake Biwa. The experiment center has plans which operate various large scale experiment on field relative to water purification, we expect that it will contribute stepping up the enterprise of water purification on public water bodies.
Ficoll fractionation for the separation of parasitized erythrocytes from malaria infected blood. (1977)

Separation and concentration of parasitized erythrocytes from infected blood was achieved by centrifugation of a sample placed in a layer on top of a cushion of a Ficoll solution with a critical density. Pure suspensions of parasitized erythrocytes were obtained from Plasmodium berghei infected rodent blood, whereas results with P. vivax infected monkey (Aotus trivirgatus) blood were partially successful. Titration experiments revealed that the parasitized erythrocytes obtained by Ficoll fractionation were infective.
New Synthetic Inhibitors of Chymotrypsin (1984)

4-Substituted carbonylphenyl ester derivatives were prepared and their inhibitory effects on chymotrypsin, trypsin, thrombin, plasmin, pancreatic kallikrein, and plasma kallikrein were examined. Among the various inhibitors tested, 4-[2-(dimethylamino)ethylaminocarbonyl]phenyl 1,2,3,4-tetrahydro-1-naphthoate hydrochloride (FK-316), 4-[(2-[4-pyrrolidinocarbonylmethyl)oxycarbonyl]-phenyl 5-methoxyindole-3-acetate dihydrochloride (FK-375), 4-[(2-[4-(piperidinocarbonylmethylpiperadino]ethyl)oxycarbonyl+ ++]phenyl 1-naphthylacetate dihydrochloride (FK-386), 4-[(2-[4-(2-[morpholino]ethyl)piperadino]ethyl)oxycarbonyl]p henyl 5-methoxy-2-methylindole-3-acetate trihydrochloride (FK-401) and 4-(4-isopropylpiperadinocarbonyl)phenyl 1,2,3,4-tetrahydro-1-naphthoate methanesulfonate (FK-448) were the most effective and specific inhibitors of chymotrypsin.
THE REACTION OF SUCROSE WITH ETHYLENE OXIDE<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE REACTION OF SUCROSE WITH ETHYLENE OXIDE1J. W. LeMAISTRE and RAYMOND B. SEYMOURCite this: J. Org. Chem. 1948, 13, 5, 782–785Publication Date (Print):September 1, 1948Publication History Published online1 May 2002Published inissue 1 September 1948https://pubs.acs.org/doi/10.1021/jo01163a026https://doi.org/10.1021/jo01163a026research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma (2001)

Asthma is the most common chronic disease of childhood whose morbidity and mortality continues to rise [1]. Drugs used in the treatment of asthma must be targeted at reversing three principle pathophysiologic features: bronchoconstriction, mucus plugging/hypersecretion and inflammation. In the past two decades, the contribution of airway inflammation to the development and progression of asthma symptoms and airway pathology has become a critical focus. Chronic airway inflammation can lead to the progressive decline and irreversible loss of lung function and airway remodelling [2]. In recent years, therapies aimed at diminishing airway inflammation have been at the forefront of asthma management. Steroids have been extensively studied and used as primary anti-inflammatory agents in the management of the asthmatic patient with persistent symptoms of varying severity. Within the last decade, however, several additional non-steroidal classes of drugs have begun to emerge as anti-inflammatory agents for the treatment of asthma. This article will focus on these non-steroidal drugs which have been developed and investigated within the last 5 years. Particular emphasis will be placed on leukotriene receptor antagonists, but anti-IgE and anti-IL-4 therapies, as well as phosphodiesterase inhibitors will also be discussed. Of these new therapies, only two leukotriene receptor antagonists, montelukast (Singulairtrade mark, Merck) and zafirlukast (Accolatetrade mark, AstraZeneca) and the 5-lipoxygenase inhibitor, zileuton (Zyflotrade mark, Abbott Laboratories), have been recommended, approved and are currently available for use in the treatment of paediatric patients with asthma in the United States.
Alleviating flu-like symptoms with dose titration and analgesics in MS patients on intramuscular interferon beta‑1a therapy: a pilot study (2007)

This study supports the findings of previous studies demonstrating no difference in the effectiveness of acetaminophen and ibuprofen in controlling flu-like symptoms associated with IFNbeta treatment in patients with relapsing-remitting MS. Trends in this small pilot study suggest that the combination of initial dose titration and analgesic administration is useful for the reduction of flu-like symptoms with IFNbeta-1a therapy.
Multiplex Immunoassay Platforms Based on Shape-Coded Poly(ethylene glycol) Hydrogel Microparticles Incorporating Acrylic Acid (2012)

A suspension protein microarray was developed using shape-coded poly(ethylene glycol) (PEG) hydrogel microparticles for potential applications in multiplex and high-throughput immunoassays. A simple photopatterning process produced various shapes of hydrogel micropatterns that were weakly bound to poly(dimethylsiloxane) (PDMS)-coated substrates. These micropatterns were easily detached from substrates during the washing process and were collected as non-spherical microparticles. Acrylic acids were incorporated into hydrogels, which could covalently immobilize proteins onto their surfaces due to the presence of carboxyl groups. The amount of immobilized protein increased with the amount of acrylic acid due to more available carboxyl groups. Saturation was reached at 25% v/v of acrylic acid. Immunoassays with IgG and IgM immobilized onto hydrogel microparticles were successfully performed with a linear concentration range from 0 to 500 ng/mL of anti-IgG and anti-IgM, respectively. Finally, a mixture of two different shapes of hydrogel microparticles immobilizing IgG (circle) and IgM (square) was prepared and it was demonstrated that simultaneous detection of two different target proteins was possible without cross-talk using same fluorescence indicator because each immunoassay was easily identified by the shapes of hydrogel microparticles.
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes (2012)

Type 1 diabetes is an autoimmune disease, hence the rationale for immunotherapy to halt disease progression. Based on knowledge gained from other autoimmune diseases and from transplantation, the first immunointervention trials used immunosuppressive drugs, e.g., cyclosporin, in patients with recently diagnosed type 1 diabetes. Although remarkable, the effect vanished following drug withdrawal. Efforts were then devoted to devise strategies to induce/restore self-tolerance and avoid chronic immunosuppression. Various approaches were identified from work in spontaneous models of autoimmune diabetes, including the use of β-cell autoantigens and monoclonal antibodies directed at relevant immune molecules such as costimulatory ligands, T-cell receptor molecules such as CD3, and B cells. Phase II and phase III trials were launched, results of which are now available. Although the endeavor is challenging, the experience gained indicates that immunotherapy appears as the real hope of inducing long-term remission of the disease provided the treatment is started early and that protocols are adapted based on lessons from the past.