gebhart/patrepeval huggingface dataset:
Principal Quality: A Virginia Study Connecting Interstate School Leaders Licensure Consortium Standards With Student Achievement (2005)

Investigators randomly selected principals from Virginia's public schools to investigate the sign4ifcant relationship that exists between principal quality and student achievement. Two persons supervising each principal were asked to complete the Interstate School Leaders Licensure Consortium (ISLLC)-based questionnaire about the principal. State achievement test data were entered for each principal's school. Those principals who had been in their schools fewer than 5 years were dropped from the study to better control for principals' effect on student achievement. Results find that principals who were rated higher on school leadership standards have schools with higher student achievement than comparable schools headed by lower-rated principals. Implications for increasing student achievement, professional development, and evaluation are discussed.
<title>Universal beamsteering mirror design using the cross blade flexure</title> (1992)

Typically, beam steering mirrors have been custom designed for specific performance and form factor requirements for each new program. In many cases, the requirements are stressing in just one or two areas, such as, bandwidth or travel. Hughes has developed and tested a universal beam steering mirror design, called the Hughes Beam Steering Mirror (HBSM), that simultaneously provides large angular mechanical travel in two areas (+/- 3.5 degree(s)), high bandwidth (1 kHz), high acceleration (1200 rad/sec<SUP>2</SUP>), low noise (< 100 nrad), with a 5 inch clear aperture reactionless mechanism in a compact envelope (< 5' X 5' X 7'). These performance parameters combined meet the demanding agile steering mirror requirements of many SDI programs, while satisfying the requirements of systems that may require only a subset of these parameters. One of two key distinctions of the HBSM is the cross blade flexure. The cross blade flexure provides low stiffness in the two desired tilt degrees of freedom, while providing very high stiffness in all other degrees of freedom. This allows for a simple mirror control law that does not require active control over other degrees of freedom, and provides infinite cycle life over a +/- 3.5 degree(s) travel range. The second unique design distinction is the slotted bobbin voice coil actuator. This design was developed to counter the effects of a metallic bobbin when high bandwidth, displacement, and acceleration are simultaneously required. This paper will present the HBSM design, the performance analysis for the cross blade flexure, the design theory for the slotted bobbin, and performance data on the HBSM mechanism.
Site Occupation of Ga and Al in Stabilized Cubic Li<sub>7–3(<i>x</i>+<i>y</i>)</sub>Ga<sub><i>x</i></sub>Al<sub><i>y</i></sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub> Garnets As Deduced from <sup>27</sup>Al and <sup>71</sup>Ga MAS NMR at Ultrahigh Magnetic Fields (2015)

Li-containing garnets, which are stabilized in their cubic modification by doping with Al or Ga, show very high Li-ion conductivities. This property qualifies them to be used as solid electrolytes in advanced all-solid-state batteries. The relation between local structures and dynamic properties, however, is still not fully understood. Here, cubic mixed-doped Li7–3(x+y)GaxAlyLa3Zr2O12 garnet solid solutions with different portions of Al and Ga were synthesized. It turned out that the solubility of Ga is higher than that of Al; the evaluation of 42 different doping compositions indicated an increase of the lattice parameter a0 with increasing Ga content. 71Ga MAS NMR spectra recorded at 21.1 T revealed two 71Ga NMR resonances, corresponding to Ga occupying both the 24d (243 ppm) and 96h sites (193 ppm). This behavior, which has been observed for the first time in this study, is very similar to that of Al. The 71Ga NMR line at 193 ppm observed here remained invisible in previous NMR studies that were carried out at lower magnetic fields. The invisibility at lower field is because of large second-order quadrupolar broadening that has a lower effect on the 71Ga NMR spectra at higher magnetic field. Most importantly, the similarity in site preference of Al and Ga found here inevitably raises a question about the significance of a blocking effect on long-range Li-ion transport. It weakens the assumption that the site preference of dopants is responsible for the higher Li diffusivity of Ga-doped samples compared to the Al-doped analogues. Concerning Li-ion dynamics, our 7Li NMR line shape measurements indicate that the change in lattice constant a0 with increasing doping level seems to have a larger influence on Li-ion dynamics than the Al:Ga ratio.
The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism (2018)

Previous research has suggested that thyroid hormone receptor alpha 1 (THRα1), a hormone responsive splice variant, may play a role in breast cancer progression. Whether THRα1 can be exploited for anti-cancer therapy is unknown. The antiproliferative and antitumor effects of dronedarone, an FDA-approved anti-arrhythmic drug which has been shown to antagonize THRα1, was evaluated in breast cancer cell lines in vitro and in vivo. The THRα1 splice variant and the entire receptor, THRα, were also independently targeted using siRNA to determine the effect of target knockdown in vitro. In our study, dronedarone demonstrates cytotoxic effects in vitro and in vivo in breast cancer cell lines at doses and concentrations that may be clinically relevant. However, knockdown of either THRα1 or THRα did not cause substantial anti-proliferative or cytotoxic effects in vitro, nor did it alter the sensitivity to dronedarone. Thus, we conclude that dronedarone's cytotoxic effect in breast cancer cell lines are independent of THRα or THRα1 antagonism. Further, the depletion of THRα or THRα1 does not affect cell viability or proliferation. Characterizing the mechanism of dronedarone's anti-tumor action may facilitate drug repurposing or the development of new anti-cancer agents.
Aminimide as hardener/curing promotor for one part epoxy resin composition (1982)

Abstract Three kinds of aminimide compounds were examined as latent hardeners/promotors for epoxy resins. Since aminimides are thermolyzed to generate tertiary amine and isocyanate, the compounds are useful as polymerization initiators for the epoxy group as well as promotors for epoxy–acid anhydride reaction. The pot life was over 30 days at 40°C for a formulated one‐part epoxy resin system. In comparison with epoxy resins cured with conventional hardeners, several interesting characteristics of the mechanical and electrical properties were observed. In particular, the epoxy resins cured by aminimides exhibited high tensile strength and high impact strength, which make them excellent curing agents for adhesive applications. The reasons for these unique properties are discussed.
A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation (2017)

The rhizomes of <i>Alpinia officinarum</i> Hance have been used conventionally for the treatment of various ailments, triggering a wide interest from the scientific research community on this ethnomedicinal plant. This review summarizes the phytochemical and pharmacological properties of the extracts and fractions from <i>A. officinarum</i>, a plant species of the Zingiberaceae family. Different parts of the plant - leaves, roots, rhizomes, and aerial parts - have been extracted in various solvents - methanol, ethanol, ethyl acetate, hexane, dichloromethane, aqueous, chloroform, and petroleum ether, using various techniques - Soxhlet extraction, maceration, ultrasonication, and soaking, whereas fractionation of the plant extracts involves the solvent-solvent partition method. The extracts, fractions, and isolated compounds have been studied for their biological activities - antioxidant, antibacterial, anti-inflammatory, anticancer, antiproliferative, inhibition of enzymes, as well as the inhibition of nitric oxide production. More findings on A. officinarum are certainly important to further develop potential bioactive drug compounds.
Automated MRI segmentation for individualized modeling of current flow in the human head (2013)

Fully automated individualized modeling may now be feasible for large-sample EEG research studies and tDCS clinical trials.
CMOS-compatible dual-output silicon modulator for analog signal processing (2008)

A broadband, Mach-Zehnder-interferometer based silicon optical modulator is demonstrated, with an electrical bandwidth of 26 GHz and V(pi)L of 4 V.cm. The design of this modulator does not require epitaxial overgrowth and is therefore simpler to fabricate than previous devices with similar performance.
Broadband Strip-Transmission Line Y-Junction Circulators (1965)

Broadband circulators have been developed which operate below resonance and cover octave bandwidths in the frequency regions 0.6-8.0 Gc. The interrelationship of voltage standing-wave ratio (VSWR) and isolation between various ports is established without imposing symmetry. The fact that building a three-port circulator is essentially a matching process is used as a basis for a successful experimental development procedure. Empirically determined criteria for broadbanding are reported with particular emphasis placed on the discussion of optimizing saturation magnetization, linewidth, strip-transmission line parameters, and magnetic biasing field. The importance of having a ferrite with low dielectric loss tangent is also discussed. The empirical data are considered in light of theoretical work done in this laboratory and in light of the papers by Bosma.
The impact of delaying enteral feeding on gastric emptying, plasma cholecystokinin, and peptide YY concentrations in critically ill patients* (2008)

In critical illness, delayed enteral feeding appears to have little impact on either GE or the enterogastric feedback hormones. However, the association between delayed feeding and increased duration of ventilation and length of stay in the ICU supports the current recommendation that enteral nutrition should be commenced early.
Elucidation of flow‐mediated tumour cell‐induced platelet aggregation using an ultrasound standing wave trap (2010)

Our results show for the first time, that during TCIPA, platelet activation disrupts cancer cell clusters and this can contribute to metastasis. Thus, selective targeting of platelet aggregate-cancer cell clusters may be an important strategy to control metastasis.
Summary Abstract: Polyimide etching and passivation downstream of an O2–CF4–Ar microwave plasma (1986)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation V. Vukanovic, G. A. Takacs, E. A. Matuszak, F. D. Egitto, F. Emmi, R. S. Horwath; Summary Abstract: Polyimide etching and passivation downstream of an O2–CF4–Ar microwave plasma. J. Vac. Sci. Technol. A 1 May 1986; 4 (3): 698–699. https://doi.org/10.1116/1.573836 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science & Technology A Search Advanced Search |Citation Search
Role of the macrophage-derived hybridoma growth factor in the in vitro and in vivo proliferation of newly formed B cell hybridomas. (1987)

It has been shown recently that monocyte-macrophage cells produce a growth factor (HGF) active on newly formed B cell hybridomas. We have studied the effect of HGF on the proliferation of an HGF-sensitive clone of B cell hybridoma. Results obtained showed that the murine P388D1 cell-derived HGF has a m.w. of 29,000 and an isoelectric point (pI) of 6.2 whereas the human monocyte-derived HGF has a m.w. of 34,000 and a pI of 4.9. The HGF activity was not mediated by interleukin 1 because the two activities could be completely separated by gel filtration. Results obtained in in vivo experiments showed that HGF-sensitive cells are tumorigenic in mice. The finding that the HGF biochemical parameters (m.w. and pI) are similar to the ones of a recently described plasmacytoma growth factor suggests that HGF and the plasmacytoma growth factor are similar and that the HGF sensitivity of SP 2/O myeloma cells is reactivated after fusion with normal B lymphocytes.
The reconstitution of denatured phosphoglycerate mutase. (1983)

The reconstitution of the tetrameric enzyme yeast phosphoglycerate mutase after denaturation in guanidine hydrochloride has been studied. Denaturation is almost completely reversible at enzyme concentrations greater than 10 micrograms/ml. Cross-linking by glutaraldehyde has been used to monitor the reassociation of the subunits; the kinetics of this process has been analyzed in terms of a model involving an equilibrium between monomer and dimer followed by a bimolecular association of two dimers to give a tetramer. Reactivation is found to parallel the appearance of tetramer. Structural changes during reconstitution have been measured by circular dichroism and fluorescence. Both methods reveal complex kinetics indicating the rapid formation of structured monomers (half-time less than 10 s), followed by slow subunit association. For comparison, preliminary reconstitution experiments were performed on the dimeric phosphoglycerate mutase from rabbit muscle.
SV40 T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype. (2002)

In most human primary bone cells, SV40 T-antigen expression was able to expand life span for a few passages before cells undergo growth arrest, described as crisis. In this study, telomerase activity was reconstituted in human osteoblast precursors (hPOB cells) and marrow stromal cells (Saka cells) transformed with the SV40 T antigen. Bone cells with telomerase activity were able to bypass crisis and show unlimited life span. Despite chromosomal aberrations observed in hPOB-tert cells, these immortalized precursors were able to differentiate into osteoblasts like precrisis hPOB cells. Saka-tert cells enhanced the formation of human osteoclast-like cells in a similar manner as Saka cells. These results demonstrate that reconstitution of telomerase activity in transformed SV40 T-antigen human osteoblast precursors or marrow stromal cells leads to the generation of immortalized cells with a preserved phenotype.
Designing two-dimensional film speakers using piezoelectric materials (2011)

A speaker is an acoustic device which produces sound through electromechanical operations. Most speakers are comprised of three-dimensional devices such as a voice coil, a permanent magnet, and an enclosure. An ac voltage applied to the voice coil generates displacement of the cone due to the magnetic interaction between the magnet and the voice coil. The displacement produces audio sound waves. Recently, many mobile electronic devices such as mobile phones have become smaller, lighter, and thinner for the sake of convenience and due to advanced technologies. A problem with this miniaturization, however, is that the volume of the produced output sounds has also decreased. In contrast to conventional three-dimensional speakers, we have designed a new type of two-dimensional flexible speaker based on the use of reverse piezoelectric effect on certain piezoelectric materials. This would be very useful in today's increasingly thinner consumer electronics devices such as mobile phones. There are other applications such as clothes, wearable computers, raincoats, etc.
Interferometric optical detection and tracking of very small gold nanoparticles at a water-glass interface (2006)

We use an interferometric detection scheme to directly detect single gold nanoparticles with a diameter as small as 5 nm in an aqueous environment. We demonstrate both confocal and wide-field detection of nanoparticles and study signal strength as a function of particle size. Furthermore, we demonstrate a detection speed up to 2 micros. We also show that gold nanoparticles can be readily distinguished from background scatterers by exploiting the wavelength dependence of their plasmon resonances. Our studies pave the way for the application of this detection scheme for particle tracking in biological systems.
Asymmetric synthesis of (-)-quinocarcin (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis of (-)-quinocarcinPhilip Garner, Wen Bin Ho, and Hunwoo ShinCite this: J. Am. Chem. Soc. 1992, 114, 7, 2767–2768Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ja00033a089https://doi.org/10.1021/ja00033a089research-articleACS PublicationsRequest reuse permissionsArticle Views787Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Cyclization Reactions of Nitriles. Part 37. Synthesis, Structure and Conformational Ambident Heterocyclization of Substituted 2‐(2‐Thiocarbamoyl‐2‐cyanoethyl)‐3‐oxo‐1‐cyclohexenolates. (1990)

Abstract The reaction between equimolar quantities of the arylmethylidenethioacetamides (I), dimedone (II) and the secondary amines (III) affords the title compounds (IV), which yield the propanethioamides (V) on treatment with HCl.
Cellular Uptake and Intracellular Trafficking of Oligonucleotides: Implications for Oligonucleotide Pharmacology (2014)

One of the major constraints on the therapeutic use of oligonucleotides is inefficient delivery to their sites of action in the cytosol or nucleus. Recently it has become evident that the pathways of cellular uptake and intracellular trafficking of oligonucleotides can strongly influence their pharmacological actions. Here we provide background information on the basic processes of endocytosis and trafficking and then review recent literature on targeted delivery and subcellular trafficking of oligonucleotides in that context. A variety of approaches including molecular scale ligand-oligonucleotide conjugates, ligand-targeted nanocarriers, and the use of small molecules to enhance oligonucleotide effects are discussed.
Two-Stage Road Sign Detection and Recognition (2007)

We propose a road sign detection and recognition method using two-stage classification strategy. In the detection phase, geometric characters of road traffic signs, Hough transformation, corner detection, and projection are used to detect the exact position of the road sign in the image under noisy and complicated environment. In the recognition phase, convolution, radial basis function (RBF) neural network and K-d tree are used to recognize the road signs in two stages. Experimental results show that most road signs can be correctly detected and recognized by our proposed method with the accuracy of 95.5%. Moreover, the method is robust against the major difficulties of road sign detection and recognition. The proposed approach would be helpful for the development of intelligent driver support system and provide effective driving assistance message.
Fast impulsive noise removal in color images (2013)

In the paper a novel switching filter based on the reduced ordering statistics, combined with the peer group concept is proposed. The new technique assigns to each pixel the sum of the distances to two closest neighbors and if the sum exceeds a specified threshold, then the pixel is declared as corrupted and replaced, otherwise it is retained. The main advantage of the novel approach is its ability to suppress the noise component, while preserving fine image details. The proposed filtering framework is characterized by a very low computational complexity, which enables its adoption in real-time applications.
Studies in Fetal Wound Healing V. A Prolonged Presence of Hyaluronic Acid Characterizes Fetal Wound Fluid (1991)

Midgestation fetal wound healing is characterized by healing without fibrosis or scar formation. The mechanisms that underlie this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid. In this study a newly developed assay was used to determine the hyaluronic acid levels in fetal and adult wound fluid. Adult wound fluid had a rapid increase in hyaluronic acid, which peaked at 3 days and decreased to 0 by 7 days. In contrast levels of hyaluronic acid in fetal wound fluid increased rapidly and remained significantly elevated for 3 weeks. This prolonged presence of hyaluronic acid in the matrix of fetal wounds creates a 'permissive' wound environment that promotes fetal fibroblast movement and proliferation and inhibits cytodifferentiation. Such a matrix environment promotes healing by regeneration rather than by scarring. This observation has therapeutic implications. The prolonged application of hyaluronic acid or hyaluronate protein complexes to wounds in children or adults may modulate healing in a manner that makes the wounds more fetal-like.
LINE-1 Hypomethylation During Primary Colon Cancer Progression (2011)

By using in-situ SBM and LCM cell selection we demonstrated early onset of LINE-1 demethylation during adenomatous change of colorectal epithelial cells and demonstrated that LINE-1 demethylation progression is linear in relation to TNM-stage progression.
Flow-aware allocation for on-chip networks (2009)

Current Virtual-Channel routers disregard potentially useful information about on-chip communication flows. This often leads to inefficient resource utilisation in existing Networks-on-Chips for flow-based communication patterns. The flow-based traffic exhibited by forthcoming applications requiring large streaming datasets (sophisticated graphical interfaces, mobile connectivity, scientific applications, etc.) lead us to propose flow additions to a Virtual-Channel network. Our flow-based refinements infer the presence of, and allocate resources to flows rather than individual packets. As a consequence, we are able to demonstrate speedups of close to 40% for synthetic flow-based traffic patterns.
The Message Session Relay Protocol (MSRP) (2007)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements.
Slicing droids (2013)

The popularity of mobile devices like smartphones and tablets has increased significantly in the last few years with many millions of sold devices. This growth also has its drawbacks: attackers have realized that smartphones are an attractive target and in the last months many different kinds of malicious software (short: malware) for such devices have emerged. This worrisome development has the potential to hamper the prospering ecosystem of mobile devices and the potential for damage is huge.