gebhart/patrepeval huggingface dataset:
Novel KIF18A Inhibitors for Treating Cancer (2020)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTNovel KIF18A Inhibitors for Treating CancerRam W. Sabnis*Ram W. SabnisSmith, Gambrell & Russell LLP, 1230 Peachtree Street NE, Suite 3100, Atlanta, Georgia 30309, United States*Email: [email protected]More by Ram W. Sabnishttp://orcid.org/0000-0001-7289-0581Cite this: ACS Med. Chem. Lett. 2020, 11, 11, 2079–2080Publication Date (Web):September 4, 2020Publication History Received25 August 2020Published online4 September 2020Published inissue 12 November 2020https://pubs.acs.org/doi/10.1021/acsmedchemlett.0c00470https://doi.org/10.1021/acsmedchemlett.0c00470editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views6030Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (822 KB) Get e-AlertscloseSUBJECTS:Cancer,Cell physiology,Cells,Inhibition,Inhibitors Get e-Alerts
One-pot synthesis of novel hierarchical bifunctional Ga/HZSM-5 nanosheets for propane aromatization (2015)

Hierarchical galloaluminosilicate nanosheets with the MFI structure have been successfully prepared by a one-pot hydrothermal process.
Section Review Cardiovascular & Renal: Recent advances in the pharmacology and therapeutic potential of potassium channel openers (1996)

Potassium channels constitute the largest group of ion channels, the opening and closing of which result in membrane hyperpolarisation and depolarisation, respectively. This effectively modulates cellular excitability by controlling the open probability of voltage-sensitive calcium and sodium channels. Potassium channel openers are a diverse collection of drugs which act on KATP or BKca. Since both channels are non-inactivating, long-lasting inhibitory effects ensue. The site and mode of action of these drugs is not known for certain but, in the case of the KATP openers, it may be the so-called sulfonyl-urea receptor which is effectively a channel β-subunit. Openers of BKca are in the early stages of scientific study but drugs active at KATP are in various phases of clinical trial. One of these, nicorandil, is currently available for use in angina pectoris and levcromakalim has completed Phase III trials in hypertension. Of other possible applications, their use in the treatment of bronchial asthma and in the irritable bladder syndrome looks promising and various applications involving the central nervous system are under consideration.
Corpus annotation for mining biomedical events from literature (2008)

The resulting event-annotated corpus is the largest and one of the best in quality among similar annotation efforts. We expect it to become a valuable resource for NLP (Natural Language Processing)-based TM in the bio-medical domain.
Development of Deep-level Photo-thermal Spectroscopy and Photo-Carrier Radiometry for the Characterization of Semi-insulating Gallium Arsenide (SI-GaAs) (2010)

Semi-insulating gallium arsenide (SI-GaAs) has gained great interest in recent years due to its wide application in optoelectronic devices and high-speed integrated circuits. An important feature of SI-GaAs is the high density of deep-level defect states, which control the electrical properties of the substrate by compensating the shallow defects. Over the years, deep-level transient spectroscopy (DLTS) and its variations have been the most effective tools employed for the characterization of deep-level defects. However, most of these techniques require a contact probe and tend to be quite restrictive in their applications’ scope. In this thesis deep-level photo-thermal spectroscopy (DLPTS), an all-optical rate-window-based technique, is presented as a novel noncontact technique for the characterization of deep-level defects in SI-GaAs. The signal-generation mechanism for DLPTS is the super-bandgap excitation of carriers, and the sub-bandgap detection of the defect’s thermal-emission process. Combined with the rate-window detection utilizing lock-in amplifiers, DLPTS measurements are performed in three different modalities: temperature-scan, pulse-rate scan, and time-scan. This work demonstrates that each mode provides unique information about the defect configuration, and, in combination, the modes offer a powerful tool for the study of defect properties and optoelectronic processes in SI-GaAs. A hierarchical carrier-emission theory is proposed to explain the thermal broadening (nonexponentiality) in photo-thermal spectra. The model is studied comparatively with the Gaussian distribution of activation energies, and their similarities demonstrate an ergodic equivalence of random energy distribution and the constrained hierarchical emission process. In addition, a rate-window gated photo-carrier radiometry (PCR) technique is developed. The original diffusion-based PCR theory is modified to reflect the signal domination by trap emission and capture rates in the absence of diffusion. Defect luminescence is collected and analyzed using photo-thermal temperature spectra and resonant detection combined with frequency scans. The study results in the identification of five radiative defect states and the defect-photoluminescence quantum efficiency.
The Next Generation of Virtual Prototyping: Ultra-Fast Yet Accurate Simulation of HW/SW Systems (2015)

Virtual Prototypes (VPs) have been now widely adopted by industry as platforms for early SW development, HW/SW co-verification, performance analysis and architecture exploration. Yet, rising design complexity, the need to test an increasing amount of software functionality as well as the verification of timing properties pose a growing challenge in the application of VPs. New approaches overcome the accuracy-speed bottleneck of today's virtual prototyping methods. These next-generation VPs are centered around ultra-fast host-compiled software models. Accuracy is obtained by advanced methods, which reconstruct the execution times of the software and model the timing behavior of the operating system, target processor and memory system. It is shown that simulation speed can further be increased by abstract TLM-based communication models and efficient hardware peripheral models. Additionally, an industrial flow for efficient model development is outlined. This support of ultra-fast and accurate HW/SW co-simulation will be a key enabler for successfully developing tomorrow's multiprocessor system-on-chip (MPSoC) platforms.
Super-sensitive Molecule-hugging Graphene Nanopores (2012)

Longitudinal resolution and lateral sensitivity are decisive characteristics that determine the suitability of a nanopore sensor for sequencing a strand of DNA as well as other important polymers. Previous modeling of DNA induced ionic current blockades in single atom thick graphene nanopores has shown these nanopores to have sufficient longitudinal resolution to distinguish individual nucleobases along the length of a DNA molecule. Here we experimentally focus on the sensitivity to small changes in DNA diameter that can be discerned with graphene nanopores. We show that remarkably large sensitivities (0.5 nA/A)are obtained when the nanopore is tailored to have a diameter close to that of the polymer of interest. Our results have been obtained with double-stranded DNA (dsDNA). Smaller graphene nanopores that can be tuned to the diameter of single-stranded DNA (ssDNA) for sequencing have only recently been demonstrated. Our results indicate that nanopore sensors based on such pores will provide excellent resolution and base discrimination, and will be robust competitors to protein nanopores that have recently demonstrated sequencing capability.
Development of reusable components through the use of adapters (2003)

As information technologies evolve, computing environments become more distributed and heterogeneous. More and more software applications written in different programming languages running on different platforms with different operating systems are required to communicate with one another over different computer networks. Conflicts resulting from having heterogeneous and distributed computing environments require strategies for software interoperability. The emerging middleware technologies, including CORBA, COM/DCOM, .NET, J2EE, and Enterprise JavaBeans offer an industrial defacto standard communication infrastructure to support the interoperability of heterogeneous applications in components. However, the implementation of a component suffers from high interaction complexities in the component that seriously degrades the application independence. Software components should be built to be independent of the context in which they are used, allowing them to be reused in many different computing environments. In this paper, we are presenting an adapter in the adapter layer of an interconnection protocol model to isolate, encapsulate, and manage a component's interactions outside the component. The dynamic interface binding was designed to allow the adapter to examine the signature of the requested services at runtime such as operation names, parameter orders, parameter types, and parameter sizes. In addition, the interface language mapping allows an interface in a specific programming language to be automatically generated from an IDL interface. The use of adapters increases the reusability of components and also simplifies the integration of the components to an application.
Analysis and elimination of systematic errors originating from coulomb mutual interaction and image charge in Fourier transform ion cyclotron resonance precise mass difference measurements (1993)

The effect of mutual Coulomb-mediated interactions between ions of two different mass-to-charge ratios (but equal ion cyclotron orbital radii) on their Fourier transform ion cyclotron resonance (FT/ICR) mass spectral frequency difference is derived analytically and measured experimentally. For a cylindrical ion trap, ion packets are modeled theoretically as infinitely extended lines of charge, and contributions to cyclotron frequency difference due to direct Coulomb repulsion between the lime charges as well as the forces arising from image charge induced on the trap electrodes by each line charge are calculated. A striking theoretical prediction is that the effect on ICR frequency difference of mutual Coulomb repulsion between ions in a mass doublet may be compensated by the image-charge effect. As a result, there is an optimal (calculable) ion cyclotron orbital radius at which the measured cyclotron orbital frequency difference between ions of two different mass-to-charge ratios is independent of mutual Coulomb-mediated interactions between the two components of the mass doublet! Moreover, if the two mass-doublet component ions are present in equal numbers, then the measured ion cyclotron orbital frequency difference is also independent of all Coulomb-mediated interactions between the two types of ions! Thus, the single largest systematic error in measurement of mass difference in a mass doublet by FT/ICR mass spectrometry may be virtually eliminated by appropriate control of ICR orbital radius and/or by performing measurements at various relative abundance ratios and extrapolating to equal relative abundance of the two mass-doublet components. We report experimental tests and verification of these predictions for two different mass doublets: (3)He(+)/(3)H(+) (cylindrical trap at 4.7 Tesla) and (12)C(1)H 2 (+) /(14) N(+) (cubic trap at 7.0 Tesla). From the latter measurement, we determine the mass of atomic nitrogen as m((14)N)=14.003 074 014(19) u.
Using digital inline holographic microscopy and quantitative phase contrast imaging to assess viability of cultured mammalian cells (2015)

Digital inline holographic microscopy was used to record holograms of mammalian cells (HEK293, B16, and E0771) in culture. The holograms have been reconstructed using Octopus software (4Deep inwater imaging) and phase shift maps were unwrapped using the FFT-based phase unwrapping algorithm. The unwrapped phase shifts were used to determine the maximum phase shifts in individual cells. Addition of 0.5 mM H<sub>2</sub>O<sub>2</sub> to cell media produced rapid rounding of cultured cells, followed by cell membrane rupture. The cell morphology changes and cell membrane ruptures were detected in real time and were apparent in the unwrapped phase shift images. The results indicate that quantitative phase contrast imaging produced by the digital inline holographic microscope can be used for the label-free real time automated determination of cell viability and confluence in mammalian cell cultures.
PDDLStream: Integrating Symbolic Planners and Blackbox Samplers via Optimistic Adaptive Planning (2018)

Many planning applications involve complex relationships defined on high-dimensional, continuous variables. For example, robotic manipulation requires planning with kinematic, collision, visibility, and motion constraints involving robot configurations, object poses, and robot trajectories. These constraints typically require specialized procedures to sample satisfying values. We extend PDDL to support a generic, declarative specification for these procedures that treats their implementation as black boxes. We provide domain-independent algorithms that reduce PDDLStream problems to a sequence of finite PDDL problems. We also introduce an algorithm that dynamically balances exploring new candidate plans and exploiting existing ones. This enables the algorithm to greedily search the space of parameter bindings to more quickly solve tightly-constrained problems as well as locally optimize to produce low-cost solutions. We evaluate our algorithms on three simulated robotic planning domains as well as several real-world robotic tasks.
IDENTIFICATION OF TWO EMBRYOGENESIS-RELATED GENES IN SWEET PEPPER (CAPSICUM ANNUUM L.) GENOME (2008)

Plant tissue culture techniques are essential part of modern plant biotech- nology. Among them especially valuable are methods for production of haploid plants via anther cultures because they possess single copy of each gene and its functions can be easily manipulated and observed in the phenotype. Capsicum annuum (L.) produces sporadically successful anther cultures. Some cultivars produce embryos readily, while others do not respond at all. Many authors at- tributed variations in ability of plants to produce anther culture to di! erences in their genotype. It was also reported that the switch of microspores devel- opmental programme from gametophyte- to sporophyte-type is regulated by transcription factors like BABY BOOM (BBM) and LEAFY COTYLEDON (LEC). Genes encoding such transcriptional factors have not been reported in sweet pepper yet. We used annotated in NCBI sequences of BBM and LEC to design degenerative primers for highly conservative regions in these genes and used them to search by PCR reactions for BBM- and LEC-like sequences in the genome of Capsicum annuum (L.), cultivar Stryama. The isolated PCR frag- ments were cloned and sequenced. The nblast in NCBI database revealed high similarity between our sequences and annotated BBM and LEC sequences. Next the obtained sequences were subjected to bioinformatics analyses to determine the exon-intron structure. Exons were translated in-silico in protein products. The protein blast of our BBM in NCBI revealed the presence of AP2-type func- tional domain, typical of BBM gene family. The LEC sequence carries CBFD- NFYB-HMF motive, typical of LEAFY COTYLEDON gene family. This is the
Oxidation causes melanin fluorescence. (2001)

The results indicate that the strong yellow fluorescence of melanin in the RPE and choroid in situ is a property of oxidized melanin and is not due to contamination of the melanin by proteinaceous or lipid materials. The data presented allow a reinterpretation of the results obtained from fluorescence investigations of melanin-containing tissue and suggest a link between melanin degradation and lipofuscin formation.
A Role for c-Raf Kinase and Ha-Ras in Cytokine-mediated Induction of Cell Adhesion Molecules (1998)

Cytokines such as tumor necrosis factor (TNFalpha) play fundamental roles in the pathophysiology of inflammation and immunity-related diseases. Despite rapid advances in our understanding of cytokine biology in recent years, definitive knowledge of the cytokine cell signaling pathways remains elusive due to the enormous complexity of these pathways and the lack of specific biological tools and reagents. Using highly specific antisense oligonucleotides that target the mRNA encoding c-Raf kinase and Ha-Ras, we show here that inhibition of c-raf and Ha-ras expression blocks the up-regulation of E-selectin and vascular adhesion molecule-1 induced by TNFalpha in endothelial cells. Induction of intercellular adhesion molecule-1 was also reduced, although to a much lesser extent, by treatment with antisense oligonucleotides. We also show that inhibition of c-raf kinase expression decreased extracellular signal-regulated kinase and c-Jun N-terminal kinase (JNK) kinase stimulation by TNFalpha. Furthermore, antisense inhibition of JNK2 also blocked TNFalpha-mediated induction of E-selectin, whereas PD98059 (mitogen-activated protein kinase kinase 1 and 2 inhibitor) had no effect on this process. These results indicate that TNFalpha induction of E-selectin and vascular adhesion molecule-1 in endothelial cells occurs through signaling pathways that are, at least in part, dependent on c-Raf kinase, Ha-Ras, and JNK2.
Laser beam distribution in the focal region (1978)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text P. J. Shayler, "Laser beam distribution in the focal region," Appl. Opt. 17, 2673-2674 (1978) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Seborrheic dermatitis: an overview. (2006)

Seborrheic dermatitis affects the scalp, central face, and anterior chest. In adolescents and adults, it often presents as scalp scaling (dandruff). Seborrheic dermatitis also may cause mild to marked erythema of the nasolabial fold, often with scaling. Stress can cause flare-ups. The scales are greasy, not dry, as commonly thought. An uncommon generalized form in infants may be linked to immunodeficiencies. Topical therapy primarily consists of antifungal agents and low-potency steroids. New topical calcineurin inhibitors (immunomodulators) sometimes are administered.
Multivariate geographic clustering in a metacomputing environment using Globus (1999)

The authors present a metacomputing application of multivariate, nonhierarchical statistical clustering to geographic environmental data from the 48 conterminous United States in order to produce maps of regions of ecological similarity, called ecoregions. These maps represent finer scale regionalizations than do those generated by the traditional technique: an expert with a marker pen. Several variables (e.g., temperature, organic matter, rainfall etc.) thought to affect the growth of vegetation are clustered at resolutions as fine as one square kilometer (1 km2). These data can represent over 7.8 million map cells in an n-dimensional (n = 9 to 25) data space. A parallel version of the iterative statistical clustering algorithm is developed by the authors using the MPI (Message Passing Interface) message passing routines. The parallel algorithm uses a classical, self-scheduling, single-program, multiple data (SPMD) organization; performs dynamic load balancing for reasonable performance in heterogeneous metacomputing environments; and provides fault tolerance by saving intermediate results for easy restarts in case of hardware failure. The parallel algorithm was tested on various geographically distributed heterogeneous metacomputing configurations involving an IBM SP3TM, an IBM SP2TM, and two SGI Origin 2000TM s. The tests were performed with minimal code modification, and were made possible by GlobusTM (a metacomputing software toolkit) and the Globus-enabled version of MPI (MPICH-G). Our performance tests indicate that while the algorithm works reasonably well under the metacomputing environment for a moderate number of processors, the communication overhead can become prohibitive for large processor configurations.
A HAZARD RATE ANALYSIS OF MIRANT'S GENERATING PLANT OUTAGES IN CALIFORNIA (2004)

A model of generator withholding is critical for analyses of market power. The California electricity market crisis of 2000-2001 saw increased utilization of fossil fuel plants. The stressed conditions could have affected normal outage rates. A hazard rate analysis applied to the Mirant generating plants indicates that higher utilization should increase outage rates. The predicted crisis outage rates should have been higher than the historical average. Actual outage rates were significantly lower than would be predicted based on pre-crisis behavior.
Study of anti-restenosis with the blodivysio dexamethasone eluting stent (STRIDE) - a multicenter trial (2002)

peer reviewed
Boosting mobility performance with Multi-Path TCP (2010)

Abstract: Fourth Generation mobile devices incorporate multiple interfaces with diverse access technologies. The current Mobile IP protocol fails to support the enhanced fault tolerance capabilities that are enabled by the availability of multiple interfaces. In particular, established Mobile IP communications cannot be preserved through outages affecting the Home Address. In this paper we describe an architecture for mobile host multihoming that enables transport layer survivability through multiple failure modes. The proposed approach relies on the cooperation between Mobile IP and Multi-Path TCP and aims to fully support multihoming and extend roaming capabilities of mobile devices.