gebhart/patrepeval huggingface dataset:
2-Hydroxycyclohexaneacetic Acid Lactones as Intermediates in the Synthesis of Hydrogenated Phenanthrenes (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2-Hydroxycyclohexaneacetic Acid Lactones as Intermediates in the Synthesis of Hydrogenated PhenanthrenesEdward M. FryCite this: J. Org. Chem. 1952, 17, 11, 1484–1491Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/jo50011a012https://doi.org/10.1021/jo50011a012research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Longitudinal Axis of the Knee and the Role of the Cruciate Ligaments in Controlling Transverse Rotation (1974)

Eleven knees were tested in a special jig to determine the location of the longitudinal axis of rotation and the role of the cruciate ligaments in controlling transverse rotation. It was found that the tibia rotates on the femur about an axis passing through the medial intercondylar tubercle of the tibial plateau. The cruciate ligaments stabilize but do not control this rotatory motion.
Screening for Cytotoxic and Antimalarial Activities in Desert Plants of the Negev and Bedouin Market Plant Products (1999)

Aqueous extracts of 66 desert plants of the Negev and Beer Sheva Bedouin market plant products were tested for antitumor, antimalarial (protozoa) and growth inhibition of wheat-rootlet activities. Pteranthus dichotomus, Gypsophila arabica, Achillea fragrantissima, Urginea maritima, and Solanum elaeagnifolium exhibited strong cytotoxicity (above 97%) against cultured melanoma cell lines. Mesembryanthemum nodiflorum, Gypsophila arabica, Hammada scoparia, Trigonella foenum-graecum and Peganum harmala had more than 80% inhibition both in rootlet and melanoma assays. Hammada scoparia, Pulicaria crispa, Centaurea eryngioides, Echinops polyceras, Ephedra aphylla, Teucrium polium, Phlomis brachyodon, Urginea maritima, Ochradenus baccatus, Verbascum fruiticulosum, Corchorus olitorius, and Peganum harmala demonstrated strong growth inhibition (above 96%) of the malaria parasite Plasmodium falciparum. The plants that were positive for antimelanoma and antimalarial activities have been under further investigation for the isolation and characterization of the anticancer and antimalarial compounds.
Escalations in workflow management systems (1997)

Work:flow m.negement systems (WFMSs) have been used to support the modeling, execution, and monitoring of business processes. Business processes consist of multiple activities, and their enactment is carried out by human agents and software systems. "Dypically, business processes and the activities constituting them have deadlines. When an activity misses its deadline, special actions may be triggered, ~efermd to as escalation. E~c.I.Hnns ~d~ect business processes, and they may even lead to the abortion of some of them. Consequently, escalafion~ may entail a high cost to an or-gAnlg~tlnU. II1 th~ paper, we present on-going research addressing wod~ow escalations. Our goal is twofold: (a) minimize the rtumbet of escalations during process execution and (b) reduce the cost associated with escalations when they cannot be avoided.
Metal Nanopowders for electrically conductive polymers (1999)

S.53-58
Time dependent changes in the pharmacokinetics of aspirin. (1979)

In an experiment carried out on six volunteers, measurement of total serum salicylate concentration was used to describe aspirin kinetics after a single 1500 mg oral dose. The availability of the drug was significantly better when it was administered at 6(00) than at 18(00) or 22(00). Also a significant time-dependence was found between the morning and evening values of both the serum half-life time of salicylate and kel. The possible relation between these results and the appearance of undesirable side effects in patients should be examined.
Bi-directional AC-DC/DC-AC converter for power sharing of hybrid AC/DC systems (2011)

In this paper, some of the aspects related to the connectivity of DC microgrids to the main grid are investigated. A prototype system has been designed and implemented to address these aspects. The described system is dependent mainly on sustainable energy sources. Hence, a special care has been given to dealing with this kind of sources while designing different components of the system. Certain features had to be maintained in the system in order to assure efficient integration of different sources such as, efficient and reliable load-feeding capability and full controllability of voltage and power flow among various buses in the system. Two different converters have been investigated; firstly, a fully controlled rectifier has been designed to tie the DC grid with the AC one. A vector decoupling controlled sinusoidal pulse width modulation (SPWM) technique has been used to allow the designed rectifier to maintain a constant output voltage while being able to control the active and reactive power drawn from the grid independently. Hence, this controlled rectifier acts as a voltage regulator for the DC microgrid and has a uni-directional power flow capability from the AC grid to the DC microgrid. Moreover, in order to allow bi-directional power flow, a bi-directional AC-DC/DC-AC converter has also been designed. The Bi-directional AC-DC/DC-AC converter controls the active power transferred from the DC grid to the AC grid while operating at unity power factor. In addition, it controls the active power transferred from the AC grid to the DC grid while operating at unity power factor. Both simulation and experimental results verify the validity of the proposed system.
Defects in cytochrome oxidase assembly in humans: lessons from yeastThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease. (2006)

The biogenesis of the inner mitochondrial membrane enzyme cytochrome c oxidase (COX) is a complex process that requires the actions of ancillary proteins, collectively called assembly factors. Studies with the yeast Saccharomyces cerevisiae have provided considerable insight into the COX assembly pathway and have proven to be a fruitful model for understanding the molecular bases for inherited COX deficiencies in humans. In this review, we focus on critical steps in the COX assembly pathway. These processes are conserved from yeast to humans and are known to be involved in the etiology of human COX deficiencies. The contributions from our studies in yeast suggest that this organism remains an excellent model system for delineating the molecular mechanisms underlying COX assembly defects in humans. Current progress suggests that a complete picture of COX assembly will be achieved in the near future.
Interconnect complexity-aware FPGA placement using Rent's rule (2001)

Field Programmable Gate Arrays (FPGAs) have gained in commercial acceptance because they offer instant manufacturing turnaround and low costs. However, FPGAs are constantly hard pressed to keep up with the requirements of the more complex and larger scale circuits which are being targeted for them. Routability of a circuit depends on the FPGA architecture, the placement, and the interconnection complexity of the circuit to be placed and routed. This paper explores the use of Rent's rule as a complexity metric for improving the placement of circuits on a target FPGA architecture, such that routing resource utilization is improved. A new simulated annealing based placement algorithm is presented and experimental results are presented to illustrate the validity of the approach for certain example circuits and the ISCAS benchmarks.
Proteinases in the joint: clinical relevance of proteinases in joint destruction (2007)

Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently, efforts have been made to establish their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis, osteoarthritis and spondyloarthritis. Matrix metalloproteinases (MMPs) are sensitive markers of disease severity and response to treatment, and therefore they have potential in the assessment of rheumatic diseases. Despite disappointing early results with synthetic inhibitors of MMPs, there is still much scope for developing effective and safe MMPs inhibitors, and consequently to deliver new options to inhibit joint destruction.
Parastomal Hernia Prevention (2014)

Hotouras, Alexander B.Sc., M.Sc., M.B.B.S.(Lond.), M.R.C.S.(Engl.), M.D.(Res.); Bhan, Chetan F.R.C.S.; Murphy, Jamie Ph.D., F.R.C.S.; Chan, Christopher L. Ph.D., F.R.C.S.; Williams, Norman S. M.S., F.R.C.S. Author Information
Metabolism of biphenyl. 2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate: the <i>meta</i>-cleavage product from 2,3-dihydroxybiphenyl by <i>Pseudomonas putida</i> (1973)

1. 2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid was isolated and identified from washed suspensions of Pseudomonas putida incubated in the presence of 2,3-dihydroxybiphenyl. 2. Benzoic acid was isolated from reaction mixtures of crude cell-free extracts incubated with 2,3-dihydroxybiphenyl. 3. The presence in the same reaction mixtures of either 4-hydroxy-2-oxovalerate or 2-hydroxypenta-2,4-dienoate was suggested by mass spectrometry. 4. The degradative pathway of biphenyl is discussed.
Effects of ionizing radiation on nanomaterials and III-V semiconductor devices. (2008)

Devices based on III-V semiconductors and nanomaterials are expected to be critical components of future microsystems as the demand for greater functionality, range of application, and robustness continue to increase. There currently is a need for small-scale power supplies which can be used to power microsystems thereby enabling autonomous functionalities. The use of III-V semiconductor-based solid state devices and nanomaterials to convert the radiant energy of a radioisotope source into electricity has been investigated as a viable option to fulfill this demand. The energy imparted to a material by incident alpha-particles, resulting in electron-hole pair formation and ionization, may be converted into usable electrical power by a radioisotope microbattery (RIMB). A model describing the spatially varying rate of ionizing energy deposited in an absorber material held in close proximity to an isotropic alpha-emitting radioisotope source has been developed. The alpha-particle energy deposition model (ADEP) allows the total energy exciting the RIMB devices to be calculated and thereby provides a means to determine the efficiency of the experimentally measured devices. Two RIMB designs are investigated including a direct conversion microbattery based on a nipi-diode structure and an indirect conversion microbattery employing radioluminescent nanophosphors. The multi-functional nature of microsystems may best be exploited by deploying them in extreme environments, such as space, where a low power consumption, small volume, and superior functionality are required. Expanding microsystems into such environments requires a full understanding of the effects that ionizing radiation will have on the optoelectronic properties of the devices and the materials which they are composed of. Irradiating devices with an isotropic alpha-particle flux is a good method for simulating the radiation damage encountered by III-V devices or nanomaterials employed in space. The large mass of alpha particles, in comparison to beta particles, leads to higher momentum transfers in nuclear interactions corresponding to a larger displacement damage dose near the surface of a material for comparably lower fluences. The effects of such irradiation on the optoelectronic properties of III-V semiconductor devices and epitaxially grown InAs quantum dots arrays are investigated. A crystal binding model based on the Tersoff interatomic potentials is developed and used to explain the increased radiation tolerance observed in the InAs quantum dot material system.
Calibrating an outdoor distributed camera network using Laser Range Finder data (2009)

Outdoor camera networks are becoming ubiquitous in critical urban areas of large cities around the world. Although current applications of camera networks are mostly limited to video surveillance, recent research projects are exploiting advances on outdoor robotics technology to develop systems that put together networks of cameras and mobile robots in people assisting tasks. Such systems require the creation of robot navigation systems in urban areas with a precise calibration of the distributed camera network. Despite camera calibration has been an extensively studied topic, the calibration (intrinsic and extrinsic) of large outdoor camera networks with no overlapping view fields, and likely to suffer frequent recalibration, poses novel challenges in the development of practical methods for user-assisted calibration that minimize intervention times and maximize precision. In this paper we propose the utilization of Laser Range Finder (LRF) data covering the area of the camera network to support the calibration process and develop a semi-automated methodology allowing quick and precise calibration of large camera networks. The proposed methods have been tested in a real urban environment and have been applied to create direct mappings (homographies) between image coordinates and world points in the ground plane (walking areas) to support person and robot detection and localization algorithms.
Modeling Flow Profiles and Dispersion in Capillary Electrophoresis with Nonuniform .zeta. Potential (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModeling Flow Profiles and Dispersion in Capillary Electrophoresis with Nonuniform .zeta. PotentialCatherine A. Keely, Tom A. A. M. van de Goor, and Douglass. McManigillCite this: Anal. Chem. 1994, 66, 23, 4236–4242Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ac00095a019https://doi.org/10.1021/ac00095a019research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Discovering Documentation for Java Container Classes (2007)

Modern programs make extensive use of reusable software libraries. For example, we found that 17% to 30% of the classes in a number of large Java applications use the container classes from the java.util package. Given this extensive code reuse in Java programs, it is important for the reusable interfaces to have clear and unambiguous documentation. Unfortunately, most documentation is expressed in English, and therefore does not always satisfy these requirements. Worse yet, there is no way of checking that the documentation is consistent with the associated code. Formal specifications present an alternative which does not suffer from these problems; however, formal specifications are notoriously hard to write. To alleviate this difficulty, we have implemented a tool which automatically derives documentation in the form of formal specifications. Our tool probes Java classes by invoking them on dynamically generated tests and captures the information observed during their execution as algebraic axioms. While the tool is not complete or correct from a formal perspective we demonstrate that it discovers many useful axioms when applied to container classes. These axioms then form an initial formal documentation of the class they describe.
Atomic force microscopy measurements of bovine serum albumin adhesion forces surfaces (2008)

A novel, direct technique has been developed to measure the interactions of bovine serum albumin (BSA) on surfaces by using atomic force microscopy (AFM) in a liquid environment. We have been able to measure adhesion forces between proteins and substrate surfaces in phosphatebuffered
saline (PBS) solution directly, without any modification to the substrate and the AFM tip. Two different surfaces have been used in the measurements: mica (hydrophilic surface) and polystyrene (hydrophobic surface).The results show that a polystyrene surface has larger adhesion forces to BSA than a mica surface. This is consistent with previous research, which demonstrated that hydrophobic surfaces enhance protein adhesion but hydrophilic surfaces do not.
The preliminary investigation of imaging photoplethysmographic system (2007)

Published under licence in Journal of Physics, Conference Series by IOP Publishing Ltd. CC-BY. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Design Sensitivity: Statistical Power for Experimental Research. (1991)

PART ONE: STATISTICAL POWER IN TREATMENT EFFECTIVENESS RESEARCH Treatment Effectiveness Research and Design Sensitivity The Statistical Power Framework Effect Size The Problematic Parameter How to Estimate Statistical Power PART TWO: USEFUL APPROACHES AND TECHNIQUES Dependent Measures Design, Sample Size, and Alpha The Independent Variable and the Role of Theory Putting It All Together
DJM: a global distributed virtual machine on the Internet (1998)

In this paper, we present the design and implementation of a novel model of distributed computing on the Internet and Intranet environment. Our model is called the Distributed Java Machine (DJM). It is a global distributed virtual machine used to realize the concept of ‘network is the computer’. DJM explores coarse-grained parallelism by using the under-utilized workstations on the network, combining the elements of object-oriented technology, distributed computing, World-Wide Web and Java programming. It can run on machines with heterogeneous hardware and software platforms without relinking or recompilation. DJM has two unique features. First, using an original applet helper mechanism, DJM allows machines without any DJM software and of different levels of ‘trust’ to work together. Secondly, DJM has implemented concurrency enhancement mechanisms (one-way message, future and redirected future) to increase the efficiency of method invocation. The prototype of DJM has been implemented and tested under both the Intranet and the Internet environments. Using the workstations from our teaching laboratories, which are already running under normal loading, experimental results show that we can achieve a speedup of about 5–8 times by 14 workstations in a Local Area Network (LAN) environment, and about 4.5 times speedup for eight workstations in a Wide Area Network (WAN) environment. © 1998 John Wiley & Sons, Ltd.
The Effect of High Speed Polarity Changing on EDM Performance. (1995)

Machining performance in the normal polarity EDM greatly differs from that in the reversed polarity one. The removal rate in the normal polarity EDM is high, though the electrode wear is large in EDM with graphite electrode. On the other hand, the removal rate in the reversed polarity EDM is relatively low, though the electrode wear is small, which leads to no electrode wear EDM under a proper machining condition. Therefore, it is considered that it might be more effective to mix both the normal polarity EDM and the reversed polarity one.In this paper, the effect of polarity changing on the EDM performance with graphite electrode is experimentally investigated, using high speed polarity changing device in which the number and the polarity of discharge can be quickly changed at will, in order to attain higher removal rate and lower electrode wear. Main conclusions obtained are as follows:(1) The removal rate takes a maximum when the reversed polarity discharge is a little mixed into the normal polarity EDM with kerosine type fluid. It is due to the removal of carbonized layer and/or heat resolved carbon of machining fluid from the workpiece surface.(2) The removal rate, the electrode wear and the surface finish in EDM with kerosine type fluid depend on the ratio of normal polarity discharge to the reversed polarity one regardless of the number of each polarity discharge in a cycle.(3) The removal rate in EDM with deionized water increases linearly with increasing the ratio of normal polarity discharge.(4) The electrode wear and the surface finish in EDM with kerosine type fluid become larger with increasing the ratio of normal polarity discharge.
BARD1 Induces BRCA1 Intranuclear Foci Formation by Increasing RING-dependent BRCA1 Nuclear Import and Inhibiting BRCA1 Nuclear Export (2002)

BRCA1 is a tumor suppressor with several important nuclear functions. BRCA1 has no known cytoplasmic functions. We show here that the two previously identified nuclear localization signals (NLSs) are insufficient for nuclear localization of BRCA1 due to the opposing action of an NH2-terminal nuclear export signal. In transfected breast cancer cells, BRCA1 nuclear localization requires both the NLSs and NH2-terminal RING domain region; mutating either of these sequences shifts BRCA1 to the cytoplasm. The BRCA1 RING element mediates nuclear import via association with BARD1, and this is not affected by cancer-associated RING mutations. Moreover, BARD1 directly masks the BRCA1 nuclear export signal, and the resulting block to nuclear export is requisite for efficient import and nuclear localization of ectopic and endogenous BRCA1. Our results explain why BRCA1 exon 11 splice variants, which lack the NLSs but retain the RING domain, are frequently detected in the nucleus and in nuclear foci in vivo. In fact, co-expression of BARD1 promoted formation of DNA damage-induced nuclear foci comprising ectopic wild-type or NLS-deficient BRCA1, implicating BARD1 in nuclear targeting of BRCA1 for DNA repair. Our identification of BARD1 as a BRCA1 nuclear chaperone has regulatory implications for its reported effects on BRCA1 protein stability, ubiquitin ligase activity, and DNA repair.
Treatment of osteochondral lesions of the talus with microfracture technique and postoperative hyaluronan injection (2011)

Randomized, controlled trial, Level I.