gebhart/patrepeval huggingface dataset:
Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics (2014)

There is little data considering relationships among human RNA, demographic variables, and primary human cell physiology. The platelet RNA and expression-1 study measured platelet aggregation to arachidonic acid, ADP, protease-activated receptor (PAR) 1 activation peptide (PAR1-AP), and PAR4-AP, as well as mRNA and microRNA (miRNA) levels in platelets from 84 white and 70 black healthy subjects. A total of 5911 uniquely mapped mRNAs and 181 miRNAs were commonly expressed and validated in a separate cohort. One hundred twenty-nine mRNAs and 15 miRNAs were differentially expressed (DE) by age, and targets of these miRNAs were over-represented among these mRNAs. Fifty-four mRNAs and 9 miRNAs were DE by gender. Networks of miRNAs targeting mRNAs, both DE by age and gender, were identified. The inverse relationship in these RNA pairs suggests miRNAs regulate mRNA levels on aging and between genders. A simple, interactive public web tool (www.plateletomics.com) was developed that permits queries of RNA levels and associations among RNA, platelet aggregation and demographic variables. Access to these data will facilitate discovery of mechanisms of miRNA regulation of gene expression. These results provide new insights into aging and gender, and future platelet RNA association studies must account for age and gender.
Reduced-rank modeling of head-related impulse responses using subset selection (2003)

This paper describes the subset selection method of modeling head-related impulse responses. The subset method is mathematical technique for choosing a set of basis functions directly from the data set that is being modeled. The subset method is compared to principal component analysis and the virtual speaker method.
Prediction of loan status in commercial bank using machine learning classifier (2017)

Banking Industry always needs a more accurate predictive modeling system for many issues. Predicting credit defaulters is a difficult task for the banking industry. The loan status is one of the quality indicators of the loan. It doesn't show everything immediately, but it is a first step of the loan lending process. The loan status is used for creating a credit scoring model. The credit scoring model is used for accurate analysis of credit data to find defaulters and valid customers. The objective of this paper is to create a credit scoring model for credit data. Various machine learning techniques are used to develop the financial credit scoring model. In this paper, we propose a machine learning classifier based analysis model for credit data. We use the combination of Min-Max normalization and K-Nearest Neighbor (K-NN) classifier. The objective is implemented using the software package R tool. This proposed model provides the important information with the highest accuracy. It is used to predict the loan status in commercial banks using machine learning classifier.
An Electrogenerated Chemiluminescence Imaging Fiber Electrode Chemical Sensor for NADH (2001)

An electrogenerated chemiluminescence (ECL)-based imaging fiber electrode chemical sensor (IFECS) for the detection of NADH is presented. In brief, an imaging fiber's distal tip was metalized with gold to serve as an electrode (i.e., an IFE). The 350-μm diameter IFE was coated with a thin, planar layer of Nafion doped with Ru(bpy)32+ to create an IFECS. An electrical contact was made to the gold layer such that Ru(bpy)32+ could be oxidized to Ru(bpy)33+ and electrochemically regenerated following the application of appropriate potentials. Following the diffusion of triethylamine or NADH into the IFE sensing layer and reaction with Ru(bpy)33+, the ECL was captured using a charge coupled device-based imaging system. The triethylamine calibration plot was linear between 0.0 and 50 mM. IFECSs represent the first demonstration whereby ECL imaging is performed through the actual sensor itself.
Effect of delayed esophageal transit on acetaminophen absorption (1985)

Twenty patients awaiting cardiac catheterization swallowed a single tablet containing acetaminophen and barium sulfate. The first 11 subjects swallowed the tablet while supine; its progress down the esophagus was followed by fluoroscopy. In 10 of these subjects, transit of the tablet was delayed in the esophagus. The other nine subjects swallowed the tablet while standing; it entered the stomach immediately. The plasma concentration profile of acetaminophen was measured in all subjects. When there was delayed esophageal transit of tablets, the initial absorption of acetaminophen (measured as the AUC over the first 60 min) was lower than that after normal esophageal transit of tablets. The peak plasma acetaminophen concentration was also lower and occurred on average 70 min later when transit was delayed. These kinetic changes decrease the effectiveness of acetaminophen as an analgesic. We recommend that, to ensure rapid and complete drug absorption, patients be advised to swallow tablets with a large amount of water while standing.
Inhibition of Type 1 Diabetes Correlated to a <i>Lactobacillus johnsonii</i> N6.2-Mediated Th17 Bias (2011)

Although it is known that resident gut flora contribute to immune system function and homeostasis, their role in the progression of the autoimmune disease type 1 diabetes (T1D) is poorly understood. Comparison of stool samples isolated from Bio-Breeding rats, a classic model of T1D, shows that distinct bacterial populations reside in spontaneous Bio-Breeding diabetes-prone (BBDP) and Bio-Breeding diabetes-resistant animals. We have previously shown that the oral transfer of Lactobacillus johnsonii strain N6.2 (LjN6.2) from Bio-Breeding diabetes-resistant to BBDP rodents conferred T1D resistance to BBDP rodents, whereas Lactobacillus reuteri strain TD1 did not. In this study, we show that diabetes resistance in LjN6.2-fed BBDP rodents was correlated to a Th17 cell bias within the mesenteric lymph nodes. The Th17 bias was not observed in the non-gut-draining axillary lymph nodes, suggesting that the Th17 bias was because of immune system interactions with LjN6.2 within the mesenteric lymph node. LjN6.2 interactions with the immune system were observed in the spleens of diabetes-resistant, LjN6.2-fed BBDP rats, as they also possessed a Th17 bias in comparison with control or Lactobacillus reuteri strain TD1-fed rats. Using C57BL/6 mouse in vitro assays, we show that LjN6.2 directly mediated enhanced Th17 differentiation of lymphocytes in the presence of TCR stimulation, which required APCs. Finally, we show that footpad vaccination of NOD mice with LjN6.2-pulsed dendritic cells was sufficient to mediate a Th17 bias in vivo. Together, these data suggest an interesting paradigm whereby T1D induction can be circumvented by gut flora-mediated Th17 differentiation.
Distributed on-demand address assignment in wireless sensor networks (2002)

Sensor networks consist of autonomous wireless sensor nodes that are networked together in an ad hoc fashion. The tiny nodes are equipped with substantial processing capabilities, enabling them to combine and compress their sensor data. The aim is to limit the amount of network traffic, and as such conserve the nodes' limited battery energy. However, due to the small packet payload, the MAC header is a significant, and energy-costly, overhead. To remedy this, we propose a novel scheme for a MAC address assignment. The two key features which make our approach unique are the exploitation of spatial address reuse and an encoded representation of the addresses in data packets. To assign the addresses, we develop a purely distributed algorithm that relies solely on local message exchanges. Other salient features of our approach are the ability to handle unidirectional links and the excellent scalability of both the assignment algorithm and address representation. In typical scenarios, the MAC overhead is reduced by a factor of three compared to existing approaches.
[Guidelines for diagnosis and treatment of allergic rhinitis (2009, Wuyishan).]. (2009)

变应性鼻炎患病率高且呈上升趋势，已成为国际关注的全球性疾病。我国针对中心城市人群的初步研究表明，平均自报患病率约为11.1%，不同地区间差异很大。为提高我国变应性鼻炎诊疗的总体水平，自1990年始，中华耳鼻咽喉科杂志编委会和中华医学会耳鼻咽喉科学分会共同制订了变应性鼻炎诊疗的相关标准，至2004年已经完成了3个版本。
Understanding IT Costs: An Exploratory Study using the Structured Case Method (2003)

Many companies are increasing their expenditure on information and communication technologies (ICTs) to obtain or even sustain a competitive advantage in their respective marketplaces. However, managers are often left with the quandary of how to evaluate investments in such technologies. Reasons of this difficulty have been suggested in the normative literature as centring on the socio-technical (human and organisational) dimensions associated with the deployment of ICTs. The inability of managers to determine the true costs of deploying ICT are considered attributable to a lack of knowledge and understanding of ICT related costs. In developing a broader picture of such costs and their respective taxonomies, the research presented in this paper uses a structured case method, to gain an understanding of how a construction firm embraced the information technology (IT) evaluation process. A review of the IT cost literature is presented and a conceptual framework (CF) to examine IT related costs is proposed. Findings from the case study are presented and discussed in the context of the CF.
Magnetite nanoparticles/polyvinyl pyrrolidone stabilized system for corrosion inhibition of carbon steel (2018)

The corrosion inhibitive effects of new polyvinylpyrrolidone stabilized crystalline super-paramagnetic nanoparticles (5–20 nm) were investigated. Several characterization techniques confirmed the high stability of the prepared stabilized nanoparticles in solution. The polarization and EIS measurements showed that the inhibition efficiency increased with increasing concentration of the magnetite nanoparticles. The results obtained from EIS and electrochemical polarization curves are in reasonably good agreement. The obtained results suggest that the prepared stabilized system is an excellent inhibitor for carbon steel corrosion in 1 M HCl solution.
Quantitation and localization of apolipoproteins [a] and B in coronary artery bypass vein grafts resected at re-operation. (1989)

Lp[a] is a lipoprotein whose plasma concentration is highly correlated with cardiovascular disease. Its protein moiety, apoLp[a], consists of two large polypeptides, apo[a] and apo B. The possible contribution of Lp[a] to atherosclerosis in saphenous vein aortocoronary bypass grafts was studied in a population of patients undergoing coronary re-bypass surgery. The vein graft tissue levels of apoLp[a] were compared with graft duration, gross and light microscopic pathology, as well as plasma levels of apoLp[a]. The localization pattern of apo[a] and apo B in vein graft tissue was determined. In addition, the plasma levels of cholesterol, triglycerides, apoproteins (apo) A-I, A-II, and E were measured. In a representative subpopulation of 17 patients with a mean age of 63 years from whom grafts with a mean duration of 112 months were resected, the mean total plasma cholesterol level was 221 mg/dl, the mean high density lipoprotein cholesterol level was 31 mg/dl, and the mean plasma triglyceride level was 228 mg/dl. In normal saphenous veins, the level of apoLp[a] was below measurable limits (less than 2 ng/mg), and the level of apo B was very low (3.3 ng/mg). In resected grafts, the mean tissue level of apoLp[a] was 32 ng/mg, and that of apo B was 70 ng/mg, demonstrating the net accumulation of these apoproteins in veins from the time of their grafting into the arterial bed. The apoLp[a]/apo B ratio was determined in 77 tissue segments from 59 grafts (28 patients) and was found to be 0.313. This tissue ratio was significantly higher (p = 0.02) than the plasma apoLp[a]/apo B ratio from these patients, which was 0.132. Immunostaining showed co-localization of apo[a] and apo B in the neointima of grafts. The most abundant pathologic features observed in resected grafts were proliferated intima (43/52), thrombus (28/52), and atherosclerotic core regions (21/52). The level of tissue apo B correlated well with the abundance of core regions (r = 0.501), whereas the level of tissue apoLp[a] did not correlate as well with this feature (r = 0.233). Although apo[a] and apo B are almost absent from normal saphenous vein, these apoproteins (and presumably the lipoproteins Lp[a] and low density lipoprotein) accumulate in bypass vein grafts. The data support the view that these lipoproteins play a significant role in vein graft atherosclerosis.
Inhibitory Effect of Some Flavonoids on Tumor Necrosis Factor- <i>α</i> Production in Lipopolysaccharide-Stimulated Mouse Macrophage Cell Line J774.1 (2003)

Certain naturally occurring flavonoids affect immunoregulatory activities in vitro and in vivo against cytokine production. Since tumor necrosis factor (TNF)-alpha is one of the major inflammatory cytokines, the effects of various dietary flavonoids on TNF-alpha production in lipopolysaccharide (LPS)-stimulated J774.1 cells were evaluated in vitro. Flavones, flavonols, and chalcone are the most potent inhibitors of production of TNF-alpha. Flavanone, naringenin, anthocyanidin, pelargodinin, and cyanidin exhibit moderate inhibitory activity. In contrast, genistein isoflavone displays weak inhibition, while eriodictyol flavanone is inactive. It is clear that the double bond between carbons 2 and 3 and the ketone group at position 4 of flavonoids are necessary for potent inhibitory effect. The difference in inhibitory action appears to depend on the categorized subclass of flavonoids.
A vivid relic under rapid transformation (2012)

TRLIB, the transformation system of the Danish National Survey and Cadastre (KMS), has served as the official tool for transformation between Danish map projections and horizontal and vertical datums for half a century. TRLIB system originated as a fairly simple system using one of the first compilers for the Algol-60 language, but it has evolved dramatically since then. Recently the extended transverse mercator implementation of TRLIB was included in PROJ, the leading open source projection package. This is well in line with other efforts towards making TRLIB more interoperable with other open source projection and transformation packages.

The main objective of this paper is to briefly outline the historical origins of TRLIB, and to describe the architectural design considerations behind an ongoing effort to make TRLIB ready for today’s requirements, most notably by making it 64-bit clean and thread safe. But since the TRLIB code is used in a large number of commercial GIS products, the design considerations are also influenced by the importance of maintaining a stable, backwards compatible version, while also utilizing this golden opportunity to simplify and improve the application program interface.
AlGaN/GaN varactor diode for integration in HEMTcircuits (2001)

Fabrication and characterisation of metal-semiconductor-metal (MSM) diodes above an AlGaN/GaN HEMT layer system for varactor applications are reported. Device fabrication uses standard HEMT processing steps, allowing integration in HEMT circuits without the need of sophisticated growth or etching techniques. Capacitance-voltage measurements exhibit CMAX/CMIN ratios up to 100, tunable by the electrode geometry. These results exceed best values for published heterostructure varactor diodes. Fabrication of AlGaN/GaN HEMTs on the same layer system with identical technology prove the potential for monolithic integration.
The N-Terminal Region of the <i>Oenococcus oeni</i> Bacteriophage fOg44 Lysin Behaves as a Bona Fide Signal Peptide in <i>Escherichia coli</i> and as a <i>cis</i> -Inhibitory Element, Preventing Lytic Activity on Oenococcal Cells (2000)

The function of the N-terminal region of the Oenococcus oeni phage fOg44 lysin (Lys44) as an export signal was investigated. We observed that when induced in Escherichia coli, Lys44 was cleaved between residues 27 and 28 in a SecA-dependent manner. Lys44 processing could be blocked by a specific signal peptidase inhibitor and was severely reduced by modification of the cleavage site. The lethal effect of Lys44 expression observed in E. coli was ascribed to the presence of its N-terminal 27-residue sequence, as its deletion resulted in the production of a nontoxic, albeit active, product. We have further established that lytic activity in oenococcal cells was dependent on Lys44 processing. An active protein with the molecular mass expected for the cleaved enzyme was detected in extracts from O. oeni-infected cells. The temporal pattern of its appearance suggests that synthesis and export of Lys44 in the infected host progress along with phage maturation. Overall, these results provide, for the first time, experimental evidence for the presence of a signal peptide in a bacteriophage lysin. Database searches and alignment of protein sequences support the prediction that other known O. oeni and Lactococcus lactis phages also encode secretory lysins. The evolutionary significance of a putative phage lysis mechanism relying on secretory lytic enzymes is tentatively discussed, on the basis of host cell wall structure and autolytic capacity.
Surfactant-enhanced Removal of Hydrophobic Oils from Source Zones (2005)

This research has demonstrated that the more hydrophobic the oil (e.g., the higher its molecular weight), the more hydrophobic the surfactant system must be to achieve desirable phase behavior. The oil hydrophobicity can be characterized by its equivalent alkane carbon number (EACN). A new approach is presented for estimating the EACN of multi-component hydrophobic nonaqueous phase liquids (NAPLs), which can be used to help guide surfactant selection. Results demonstrate that achieving middle phase microemulsions is more complicated for high EACN oils (e.g. hexadecane with an EACN of 16). An Aerosol-OT (AOT)/ Tween 80 system was identified in batch studies and evaluated in column studies. In less than five injected pore volumes, this surfactant system removed greater than 99% of residual hexadecane from a vertical glass bead column by both mobilization and supersolubilization mechanisms. Counter-flow liquid-liquid extraction conducted in porous hollow fiber membranes was shown to effectively separate hydrophobic oils from surfactant solutions, thereby regenerating the surfactant for reuse. This research thus demonstrates that surfactant enhanced remediation of hydrophobic oils is a viable technology, worthy of further development.
High transmission float glass for solar applications (2000)

Antireflective quarter-wave single layers with an improved abrasion resistance were prepared from sols by dip coating of float glasses, which can be used for covering solar cells and collectors. The coating sols are based on tetraalkoxysilane hydrolyzed in the presence of different organic additives, eg. polymers. This kind of sols lead to a stable pore structure in the pre-annealed film, which allows to treat it even at temperatures neccessary for glass strengthening. A heat treatment above 600 °C improved the abrasion resistance, but was not accompained by a reduction of the pore volume as would commonly be expected. The resulting porous film therefore showed the required effective refractive index of < 1.3, and increased the transmission of such coated low-iron glass up to 99.6 % in the visible spectral range and 97.0 % in the solar spectral range.
Highly active antiretroviral therapy significantly improves the prognosis of patients with HIV-associated progressive multifocal leukoencephalopathy (1998)

This study of a large cohort of patients with confirmed PML indicates that AIDS patients with PML may benefit significantly from HAART. All patients with PML should be offered optimal antiretroviral combination therapy.
Respiration as a reliable physiological sensor for controlling cardiac pacing rate. (1984)

A study was carried out to determine whether variations in the respiration rate during physical exercise could be used as a physiological variable in controlling the rate of an implanted pacemaker. The relation between respiration rate and heart rate was significantly correlated in 73 patients (19 with normal lung function, four with restrictive pulmonary disease, and 50 with obstructive airways disease) during repeated calibrated ergometric tests; no significant differences were found between the subgroups. An external computerised programmable system with algorithm control activated by a radio frequency system was used to vary the cardiac stimulation rate in relation to respiration rate in 11 patients implanted with ventricular inhibited pacemakers. In addition, a prototype programmable pacemaker dependent on respiration rate was implanted in two patients. Maximum values of oxygen uptake, minute ventilation, and work time were increased during the exercise stress tests when the variable cardiac pacing rate was used. Thus respiration rate appears to be a valid and stable physiological variable for controlling the cardiac stimulation rate in order to improve cardiac output in patients dependent on pacemakers.
A complete collection of single‐gene deletion mutants of <i>Acinetobacter baylyi</i> ADP1 (2008)

We have constructed a collection of single-gene deletion mutants for all dispensable genes of the soil bacterium Acinetobacter baylyi ADP1. A total of 2594 deletion mutants were obtained, whereas 499 (16%) were not, and are therefore candidate essential genes for life on minimal medium. This essentiality data set is 88% consistent with the Escherichia coli data set inferred from the Keio mutant collection profiled for growth on minimal medium, while 80% of the orthologous genes described as essential in Pseudomonas aeruginosa are also essential in ADP1. Several strategies were undertaken to investigate ADP1 metabolism by (1) searching for discrepancies between our essentiality data and current metabolic knowledge, (2) comparing this essentiality data set to those from other organisms, (3) systematic phenotyping of the mutant collection on a variety of carbon sources (quinate, 2-3 butanediol, glucose, etc.). This collection provides a new resource for the study of gene function by forward and reverse genetic approaches and constitutes a robust experimental data source for systems biology approaches.
Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia (2001)

Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined whether minocycline reduces excitotoxicity in primary neuronal cultures. Minocycline (0.02 microm) significantly increased neuronal survival in mixed spinal cord (SC) cultures treated with 500 microm glutamate or 100 microm kainate for 24 hr. Treatment with these excitotoxins induced a dose-dependent proliferation of microglia that was associated with increased release of interleukin-1beta (IL-1beta) and was followed by increased lactate dehydrogenase (LDH) release. The excitotoxicity was enhanced when microglial cells were cultured on top of SC cultures. Minocycline prevented excitotoxin-induced microglial proliferation and the increased release of nitric oxide (NO) metabolites and IL-1beta. Excitotoxins induced microglial proliferation and increased the release of NO metabolites and IL-1beta also in pure microglia cultures, and these responses were inhibited by minocycline. In both SC and pure microglia cultures, excitotoxins activated p38 mitogen-activated protein kinase (p38 MAPK) exclusively in microglia. Minocycline inhibited p38 MAPK activation in SC cultures, and treatment with SB203580, a p38 MAPK inhibitor, but not with PD98059, a p44/42 MAPK inhibitor, increased neuronal survival. In pure microglia cultures, glutamate induced transient activation of p38 MAPK, and this was inhibited by minocycline. These findings indicate that the proliferation and activation of microglia contributes to excitotoxicity, which is inhibited by minocycline, an antibiotic used in severe human infections.