gebhart/patrepeval huggingface dataset:
Targeting memory processes with drugs to prevent or cure PTSD (2012)

Advances in the understanding of stress biology and mechanisms of fear conditioning plasticity provide a rationale for treatment approaches that may reduce hyperarousal and dysfunctional aversive memories in PTSD. One challenge is to determine if these components are independent or reflect a common underlying neurobiological alteration. Numerous agents reviewed have potential for reducing PTSD core symptoms or targeted symptoms in chronic PTSD. Promising early data support drug approaches that seek to disrupt dysfunctional aversive memories by interfering with consolidation soon after trauma exposure, or in chronic PTSD, by blocking reconsolidation and/or enhancing extinction. Challenges remain for achieving selectivity when attempting to alter aversive memories. Targeting the underlying traumatic memory with a combination of pharmacological therapies applied with appropriate chronicity, and in combination with psychotherapy, is expected to substantially improve PTSD treatment.
Combined blockade of vascular endothelial growth factor and programmed death 1 pathways in advanced kidney cancer. (2017)

Targeted and immune-based therapies have improved outcomes in advanced kidney cancer, yet novel strategies are needed to extend the duration of these benefits and expand them to more patients. Combined inhibition of vascular endothelial growth factor (VEGF) and the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathways with therapeutic agents already in clinical use may offer such a strategy. Here, we describe the development and clinical evaluation of VEGF inhibitors and, separately, PD-1/PD-L1 inhibitors. We present preclinical evidence of interaction between these pathways and the rationale for combined blockade. Beyond well-known effects on pathologic angiogenesis, VEGF blockade also may decrease immune tolerance and enhance PD-1/PD-L1 blockade. We conclude with the results of several early trials of combined VEGF and PD-1/PD-L1 blockade, which demonstrate encouraging antitumor activity, and we pose questions for future study.
Identification of gene expression signatures in autoimmune disease without the influence of familial resemblance (2005)

Even though autoimmune diseases are heterogeneous, believed to result from the interaction between genetic and environmental components, patients with these disorders exhibit reproducible patterns of gene expression in their peripheral blood mononuclear cells. A portion of this gene expression profile is a property of familial resemblance rather than autoimmune disease. Here, we wanted to identify the portion of this gene expression profile that is independent of familial resemblance and determine whether it is a product of disease duration, disease onset or other factors. By employing supervised clustering algorithms, we identified 100 genes whose expression profiles are shared in individuals with various autoimmune diseases but are not shared by unaffected family members of individuals with autoimmune disease or by controls. Individuals with early disease (1 year after onset) and established disease (10 years after onset) exhibit a near-identical expression pattern, suggesting that this unique profile is a product of disease onset rather than disease duration.
Recognize Actions by Disentangling Components of Dynamics (2018)

Despite the remarkable progress in action recognition over the past several years, existing methods remain limited in efficiency and effectiveness. The methods treating appearance and motion as separate streams are usually subject to the cost of optical flow computation, while those relying on 3D convolution on the original video frames often yield inferior performance in practice. In this paper, we propose a new ConvNet architecture for video representation learning, which can derive disentangled components of dynamics purely from raw video frames, without the need of optical flow estimation. Particularly, the learned representation comprises three components for representing static appearance, apparent motion, and appearance changes. We introduce 3D pooling, cost volume processing, and warped feature differences, respectively for extracting the three components above. These modules are incorporated as three branches in our unified network, which share the underlying features and are learned jointly in an end-to-end manner. On two large datasets, UCF101 [22] and Kinetics [16], our method obtained competitive performances with high efficiency, using only the RGB frame sequence as input.
Matrices of Acidic <i>β</i>‐Sheet Peptides as Templates for Calcium Phosphate Mineralization (2008)

De novo designed amphiphilic and acidic β-sheet peptides in the form of monolayers and fibril assemblies are used as templates for monitoring calcium phosphate nucleation. The regular arrangement of negatively charged aspartic acid residues in a solution supersaturated with respect to apatite induces the nucleation of amorphous calcium phosphate, which over time transforms into apatite (see figure). This study demonstrates the bottom-to-top design and synthesis of new mineralized-peptide composite biomaterials.
Boundary conditions for the numerical solution of wave propagation problems (1978)

Abstract Many finite difference models in use for generating synthetic seismograms produce unwanted reflections from the edges of the model due to the use of Dirichlet or Neumann boundary conditions. In this paper we develop boundary conditions which greatly reduce this edge reflection. A reflection coefficient analysis is given which indicates that, for the specified boundary conditions, smaller reflection coefficients than those obtained for Dirichlet or Neumann boundary conditions are obtained. Numerical calculations support this conclusion.
Efficient on-line SPAM filtering for encrypted messages (2015)

Spamming is the practice of sending bulk messages through an on-line medium to people connected to it. This could be emails, instant messages or social media messages. Social networking sites that help sending and re-sharing messages became common instantly and their user base, inter-user connectivity are increasing at exorbitant rates. Spammers use such sites to instantly spread messages, which often contain even flavored sensitive information, to a wider community of users. Effective filtering of such messages is challenging for two reasons. Firstly, the filter should operate in real time on large volume of data. Secondly, confidentiality of HAM (not SPAM) messages should not be lost. The secure channel existing between the service provider and the user in social networking sites allows filtering the messages only at the service provider end, after decryption. Hence the filter overhead is high at the server side and privacy of legitimate (HAM) messages are not preserved. We propose a novel distributed filtering scheme which can perform SPAM filtering on secure (SSL encrypted) messages without decryption. The power of distributed processing solves the filter overhead at the server side and provides the required real time filter without loss of privacy of the HAM messages.
Chitosan Modification of Adenovirus to Modify Transfection Efficiency in Bovine Corneal Epithelial Cells (2010)

Chitosan can provide a platform for chemical modification of Ad, which offers potential for further in vivo applications.
Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma (2015)

There are common patterns of gene expression in the sputum and blood of children and adults that are associated with near-fatal, severe, and milder asthma.
BREVIARIO. PRESENTAN BIOBIBLIOGRAFÍA DE GABRIEL GUTIÉRREZ PANTOJA (2005)

EN EL MUSEO DE ARTE CONTEMPORANEO DE AGUASCALIENTES SE PRESENTO EL LIBRO ELECTRONICO DEL PENSAMIENTO ACALITENSE CONTEMPORANEO, DE GABRIEL GUTIERREZ PANTOJA, DEL INSTITUTO DE INVESTIGACIONES BIBLIOGRAFICAS (IIB) DE LA UNAM. EN LA PRESENTACION DE LA OBRA, GUTIERREZ PANTOJA SENALO QUE SE BUSCA CONTINUAR CON UNA LINEA DE INVESTIGACION PROPUESTA E IMPULSADA POR ERNESTO DE LA TORRE VILLAR, QUIEN PROMOVIO LA REALIZACION DE LAS BIOBIBLIOGRAFIAS DE LOS ESCRITORES DE LA REPUBLICA MEXICANA, EN LAS CUALES SE INCLUYE A TODOS LOS autorES DE LAS DISTINTAS RAMAS DEL CONOCIMIENTO. CABE SENALAR QUE LAS BIOBIBLIOGRAFIAS QUE APARECEN EN ESTA PRIMERA EDICION SON LAS DEL PERIODISTA EZEQUIEL ESTRADA PEREZ; LOS DOCTORES ALFONSO DE LUNA JIMENEZ, ALFONSO PEREZ ROMO, JESUS GOMEZ SERRANO Y MANUEL BOSQUE ROMO; DEL LICENCIADO SAUL R. GARIBAY ARRIAGA; DEL INGENIERO JUAN FRANCISCO TORRES ORNELAS Y LA DE LA MAESTRA CAROLINA CASTRO PADILLA. TAMBIEN SE INCLUYEN LAS DE ALEJADNRO TOPETE DEL VALLE Y JOSE TRINIDAD VELA SALAS, Y DEL DOCTOR MANUEL BOSQUE CHAVEZ, YA FALLECIDOS. EN EL ACTO SE MANIFESTO TAMBIEN EL INTERES DE QUE SE CONTINUE CON ESTE TRABAJO DE INVESTIGACION CON EL QUE EL IIB Y LA UNAM MANTIENEN SU PRESENCIA EN AGUASCALIENTES.
Oral Desipramine and Topical Lidocaine for Vulvodynia (2010)

I.
Endoscopic ultrasound-guided fine-needle aspiration biopsy (2002)

EUS-FNAB is a safe and accurate diagnostic procedure for the evaluation of intramural and extramural lesions of the gastrointestinal tract. In the majority of cases, it obviates the need for more invasive diagnostic procedures to obtain a tissue diagnosis.
A novel generic graph model for traffic grooming in heterogeneous WDM mesh networks (2003)

As the operation of our fiber-optic backbone networks migrates from interconnected SONET rings to arbitrary mesh topology, traffic grooming on wavelength-division multiplexing (WDM) mesh networks becomes an extremely important research problem. To address this problem, we propose a new generic graph model for traffic grooming in heterogeneous WDM mesh networks. The novelty of our model is that, by only manipulating the edges of the auxiliary graph created by our model and the weights of these edges, our model can achieve various objectives using different grooming policies, while taking into account various constraints such as transceivers, wavelengths, wavelength-conversion capabilities, and grooming capabilities. Based on the auxiliary graph, we develop an integrated traffic-grooming algorithm (IGABAG) and an integrated grooming procedure (INGPROC) which jointly solve several traffic-grooming subproblems by simply applying the shortest-path computation method. Different grooming policies can be represented by different weight-assignment functions, and the performance of these grooming policies are compared under both nonblocking scenario and blocking scenario. The IGABAG can be applied to both static and dynamic traffic grooming. In static grooming, the traffic-selection scheme is key to achieving good network performance. We propose several traffic-selection schemes based on this model and we evaluate their performance for different network topologies.
Tamoxifen and toremifene in breast cancer: comparison of safety and efficacy. (1998)

Due to the paucity of long-term clinical data on toremifene, important unresolved questions remain, which include its effects on bone mineral density, the frequency of cardiac events, and the risk for endometrial cancer. Tamoxifen has been associated with maintenance of bone mineral density, a reduction in cardiac events, and a slightly increased risk of endometrial cancer. Toremifene is not likely to be used as second-line therapy after tamoxifen failure due to cross-resistance, and its ultimate place in therapy of advanced breast cancer remains to be determined.
The effect of fuel moisture content on the spread rate of forest fires in the absence of wind or slope (2017)

Most studies on the effect of fuel moisture content (FMC) on forest fire behaviour focus on dead fuel moisture; mechanisms of fire spread in live vegetation are considered to remain unexplained by current theory and modelling. In this work, an empirical model for quantifying the effect of FMC on the ratio between spread rate and fuel bed height of fires in the absence of wind or slope was proposed. The model was fitted using data from laboratory experiments, carried out in fuel beds representative of natural litter and shrubland fuel complexes in a wide range of FMC (6–179%), and tested against data from field experiments and wildfires. The pattern of spread rate variation with FMC, namely its reduced rate for values above ~80%, was explained by the ratio between fuel low heat content and energy required for ignition.
Effect of transurethral split of the prostate using a double-columnar balloon catheter for benign prostatic hyperplasia (2016)

We aimed to evaluate the long-term therapeutic effect of transurethral split of the prostate (TUSP) with a newly improved double-columnar balloon catheter on patients with benign prostatic hyperplasia (BPH).Total 565 BPH patients (mean age 73.6 years, range 46-94 years) who underwent TUSP surgery between January 2006 and January 2015 were included. Patient's baseline characteristics, prostate size, PSA, preoperative and postoperative maximum urinary flow rate (Qmax), postvoid residual (PVR), international prostate symptoms score (IPSS) and quality of life (QOL) score, perioperative data and postoperative complications were recorded.The mean preoperative prostates size was 48.6 ± 8.2 mL (range 33-230 mL), and the PSA level was 0.8 to 18.6 ng/mL. The mean duration of TUSP procedure from the catheter localization to the split of capsula prostatica was ∼10 minutes. After surgery, the mean Qmax increased from 5.2 ± 1.4 to 12.8 ± 2.2 mL/s (P < 0.001). Patients had improved mean PVR, QOL score, and IPSS after TUSP (76 ± 8 vs 20 ± 8.5 mL, 4.6 ± 0.2 vs 1.4 ± 0.3, and 20.2 ± 4.4 vs 6.6 ± 1.1, respectively, all P < 0.001). Until September 2014, 328 patients were successfully followed up for a long-term period of 38 to 99 months. There was no other case of recurrence with dysuria despite 2 recurrent cases.The TUSP with a double-columnar balloons catheter was a safe and long-term efficient treatment for BPH, with minimal invasion, short operative time, few postoperative complications, and low recurrence rate.
Charge storage frequency multipliers (1968)

Frequency multiplication by means of a nonlinear charge storage element is investigated. This element is assurmed to have an abrupt transition from an infinite to a zero capacitance. An analysis of a frequency multiplier circuit utilizing such an element is carried out with certain limitations imposed on the mode of operation in order to make possible an algebraic solution; namely that 1) only a fundamental and one harmonic current be applied to the nonlinear element, 2) only particular conduction angles be permitted, and 3) the fundamental and harmonic be subject to a particular phase relationship. These limitations permit an algebraic solution for circuit performance for any multiplication factor and for a range of conduction angles. The analysis yields directly the input and output resistances of the multiplier, in terms of which the conversion efficiency and power handling capability are derived. Design data are presented for circuits with muitiplication factors of between 2 and 20.
Building integrated software development environments. Part I (1992)

The conceptual modeling approach of the IPSEN (Integrated Project Support Environment) project for building highly integrated environments is based on using attributed graphs to model and implement arbitrary object structures, in particular all kinds of software documents and their relationships. A language based on graph grammars, called PROGRESS (PROgrammed Graph REwriting SyStems), and a suitable method for the application of this language, called graph grammar engineering, have been developed over the last ten years. This language and method are being extensively used for specifying the complex graph structures of internal document representations as well as for specifying the functionality of all tools (editors, browsers, analyzers, debuggers) working on these internal rpresentations. This paper explains the language and the method for applying the language based on a pragmatic nontrivial example of a software production process and its corresponding documents. In particular, it is shown why and how a graph grammar-based strongly typed language is perfectly suitable to formally specify highly integrated software tools. In addition, it is shown that the implementation of these tools (i.e., an environment composed of these tools) is systematically being derived from the formal specifications.
Control of Domain Wall Position by Electrical Current in Structured Co/Ni Wire with Perpendicular Magnetic Anisotropy (2008)

We report the direct observation of the current-driven domain wall (DW) motion by magnetic force microscopy in a structured Co/Ni wire with perpendicular magnetic anisotropy. The wire has notches to define the DW position. It is demonstrated that single current pulses can precisely control the DW position from notch to notch with high DW velocity of 40 m/s.
The Retrospective Analysis of Effects of <i>H Gambitang (GB-001) </i>on Weight Loss in Pre- and Post-Menopausal Obese Woman (2020)

Objectives: The purpose of this study is to verify the effects of H Gambitang (GB-001) on body composition and basal metabolic rate in pre-and post-menopausal obese woman retrospectively. Methods: The study was conducted on 57 middle-aged obese women. They were divided into two groups; pre-menopausal obesity group (Pr-MOG; n=34) and post-menopausal obesity group (Po-MOG; amenorrhea was continued to 14~48 month, n=23) with no significant difference of age, height, body weight and body mass index. All subjects took herbal medicine 3 times a day, for 6 weeks during treatment period. The weight, height, body fat mass, skeletal muscle mass, and basal metabolic rate of all subjects were measured on first visit. The following measurements were repeated after 2 weeks (2nd), 4 weeks (3rd) and 6 weeks (4th) with Inbody 370 (Biospace) equipment to identify changes of body fat mass, skeletal muscle mass, and basal metabolic rate. Results are represented as mean and standard deviation. Results: Po-MOG showed significantly lower decrease rate in weight reduction on 2~6 weeks while significantly higher decrease rate in skeletal muscle reduction on 4~6 weeks. There were no significant differences between two groups in body fat reduction rate and basal metabolic increasing rate. Conclusions: H Gambitang (GB-001) can be used not only in Pr-MOG but in Po-MOG in weight loss although the effect can be lower in Po-MOG. To prevent skeletal muscle mass loss in Po-MOG, following study on adjusting dose and components of H Gambitang (GB-001) thought to be necessary.
A smart platform with cognitive techniques for narrowband power line communication (2012)

Power Line Communication (PLC) is becoming a strong alternative technology which enables communication on the ubiquitous electrical power supply networks. To overcome the main problem of PLC-the harsh channel characteristics, we combine the idea of Cognitive Radio (CR) and a smart SoC platform for narrowband PLC baseband processing is presented. In our platform, spectrum energy detection is made to cognize the channel condition, and accordingly the transmission parameters like the carrier frequency, modulation scheme, error codes and data rate could be adapted dynamically with good configurability to obtain best performance. Results have shown that CR scheme works efficiently and high throughput is achieved on our platform.
Sigma Gamma Epsilon 2014 W.A. Tarr Awards (2015)

First established in March 1949, the W. A. Tarr Award was created to distinguish outstanding students in the Earth Sciences. A list of the individuals who received this award for the 2013-2014 academic year as well as the qualifying criteria for the award are provided.
Two different forms of endothelin receptors in rat lung (1989)

We provided evidence for the presence of two distinct types of rat endothelin (ET) receptors having different molecular masses by affinity labelling of rat lung membranes with 125I-ET-1, ET-2 and ET-3 and SDS-PAGE followed by autoradiography. One type, which is 44 kDa has a higher affinity for ET-1 and -2 than ET-3, whereas the other type, which is 32 kDa, preferably interacts with ET-3 rather than ET-1 and -2.
Prehospital Cardiopulmonary Resuscitation (1985)

TWO PARADOXES lie behind the question posed in the title of this article. First, rapid and widespread dissemination of the technique of cardiopulmonary resuscitation (CPR) occured before the underlying physiology was fully understood. Second, data that indicate discouragingly low coronary and carotid artery flow rates contrast sharply with the obvious lifesaving capacity of basic CPR. <h3>CPR</h3> In the early 1960s, Kouwenhoven et al<sup>1</sup>demonstrated the effectiveness of closed-chest compressions for cardiac arrest; rapid worldwide dissemination of the technique soon followed. By 1974, the endorsement of influential groups such as the American Heart Association secured broad acceptance for standard CPR.<sup>2</sup>Kouwenhoven and co-workers thought that during CPR blood was expelled by compression of the heart between the sternum and vertebral bodies. Later, however, various research laboratories conducted what were, in effect, post hoc investigations into the physiology of CPR; by the 1980s, few researchers subscribed to Kouwenhoven and co-workers'
Resolution Improvement of All-Optical Analog-to-Digital Conversion Employing Self-frequency Shift and Self-Phase-Modulation-Induced Spectral Compression (2008)

We demonstrate and investigate resolution improvement of optical quantization using soliton self-frequency shift (SSFS) and optical coding using optical interconnection for an all-optical analog-to-digital conversion (ADC). Incorporating spectral compression into the optical quantization allows us to improve the resolution bit according to the spectral compression ratio with keeping its throughput. The proposed scheme consists of optical quantization using SSFS and self-phase modulation (SPM) induced spectral compression and optical coding using optical interconnection based on a binary conversion table. In optical quantization, the powers of input signals are discriminated by referring to the center wavelengths after the SSFS. The compression of the spectral width allows us to emphasize the differences of their center wavelengths, and improve the number of resolution bits. Optical interconnection generates a bit-parallel binary code by appropriate allocation of a level identification signal, which is provided as a result of optical quantization. Experimental results show the eight periods transfer function, that means, the four read-out bit operation of the proposed scheme in binary code. Simulation results indicate that the proposed optical quantization has the potential of 100 GS/s and 4-b resolution, which could surpass the electrical bandwidth limitations.