gebhart/patrepeval huggingface dataset:
Forecasting supply and demand with reliable facts and figures (1995)

One activity of the North American Electric Reliability Council (NERC) is the annual compilation of electric utilities' forecast relating to electricity supply and demand. The author describe how this data is available to the industry in a database and software package known as ES&D, which provides data in a concise and useful format to satisfy the needs of a wide variety of industry audiences. From the mid-1970s to 1993, ES&D was published as a printed report. Since 1994, it has been published only in electronic format, with each publication including the current forecast data set and the four most recent data sets.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A novel positive tetracycline‐dependent transactivator (rtTA) variant with reduced background activity and enhanced activation potential (2002)

The tetracycline-controlled transcription system has become one of the most potent systems for experimental manipulations of transcription levels in vivo. Here we report on rtTA variants, which were generated by combining the existing positively regulated Tet repressor domains of rtTA and rtTA-M2 with a modified and multimerized minimal transactivation domain from VP16 (L-domain). A transactivator with multimerized L-domains shows drastically reduced background activity and enhanced transcriptional activation on different tetracycline-responsive promoters. The new rtTA variants require higher doses of doxycycline and display a more linear dose-response curve than the original rtTA or rtTA-M2 proteins.
A comparison between miniemulsion and conventional emulsion terpolymerization of styrene, 2‐ethylhexyl acrylate and methacrylic acid (1993)

Abstract The kinetics of the high solids content miniemulsion terpolymerization of styrene, 2‐ethyl hexyl acrylate and the methacrylic acid and the final properties of the latexes produced by this method were compared with those resulting from the corresponding conventional emulsion polymerization process. The final latex properties considered were: latex viscosity both prior and after neutralization, mechanical stability, chemical stability, and freeze‐thaw stability. © 1993 John Wiley & Sons, Inc.
Relationship between Structures and Biological Activities of Mycoplasmal Diacylated Lipopeptides and Their Recognition by Toll-Like Receptors 2 and 6 (2004)

The lipopeptide FSL-1 [S-(2,3-bispalmitoyloxypropyl)-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe, Pam(2)CGDPKHPKSF] synthesized on the basis of the N-terminal structure of a Mycoplasma salivarium lipoprotein capable of activating normal human gingival fibroblasts to induce the cell surface expression of ICAM-1 revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha as the Mycoplasma fermentans-derived lipopeptide MALP-2 (Pam(2)CGNNDESNISFKEK), a potent macrophage-activating lipopeptide, did. The level of the activity of FSL-1 was higher than that of MALP-2. This result suggests that the difference in the amino acid sequence of the peptide portion affects the activity because the framework structure other than the amino acid sequence of the former is the same as that of the latter. To determine minimal structural requirements for the activity of FSL-1, the diacylglyceryl Cys and the peptide portions were examined for this activity. Both portions did not reveal the activity. A single amino acid substitution from Phe to Arg and a fatty acid substitution from palmitic acid to stearic acid drastically reduced the activity. Similar results were obtained in measuring the NF-kappaB reporter activity of FSL-1 to human embryonic kidney 293 cells transfected with Toll-like receptor 2 and 6, together with a NF-kappaB-dependent luciferase reporter plasmid. These results suggest that both the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6 and that the recognition of FSL-1 by Toll-like receptors 2 and 6 appears to be hydrophobic.
Analysis of Frequency-Conversion Techniques in Measurements of Microwave Transistor Noise Temperatures (1977)

Frequency-conversion effects on microwave effective noise temperature measurements are analyzed and conditions under which they are noticeable are given. When necessary, the experimental data can be corrected using the analytical relationships derived here.
Interleukin‐6 enhances the activity of in vivo long‐term reconstituting hematopoietic stem cells in “hypoxic‐like” expansion cultures ex vivo (2015)

The addition of IL-6 to the cytokine cocktail further improves our expansion procedure based on atmospheric O2 concentration-exposed HRMCs by enhancing the maintenance of the most primitive HSCs without a negative impact on the less primitive HSC populations and CFCs.
Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms (2008)

Recent studies have shown that macrophages play an important part in both tumor initiation and various key steps in growth and metastasis. These cells show a remarkable degree of plasticity during tumor development with a "switch" in macrophage phenotypes occurring during the course of tumor progression. During chronic inflammation they appear to predispose a given tissue to tumor initiation by the release of factors that promote neoplastic transformation. Following this, their phenotype shifts more toward one that is immunosuppressive and supports tumor growth, angiogenesis, and metastasis. In this review, we discuss the evidence for this plasticity of macrophage functions, the specific signaling mechanisms that may be regulating it, and the new targets for anticancer therapies highlighted by these findings.
Tumor necrosis treatment of ME-180 human cervical carcinoma model with 131I-labeled TNT-1 monoclonal antibody. (1989)

In contrast to normal tissues, many malignant tumors contain a high proportion of dead and dying cells. The loss of membrane integrity that accompanies cellular degeneration permits macromolecules, including antibodies, to freely enter the cell cytoplasm. Based upon these observations, it was hypothesized that monoclonal antibodies to intracellular antigens, which are integral structural components and are retained by degenerating cells, may be used to target a wide range of human malignancies. Previous studies by our laboratory utilizing these principles have demonstrated the feasibility of imaging four different histological types of human cancer in a nude mouse model, using monoclonal antibodies directed against insoluble intranuclear antigens. The present study describes the application of this approach, designated tumor necrosis treatment, for the radioimmunotherapy of transplantable ME-180 human cervical carcinomas in the nude mouse. Groups of tumor-bearing nude mice received three weekly treatments of 150 or 300 microCi of 131I-labeled experimental (TNT-1) or control (Lym-1) monoclonal antibodies. Detailed biodistribution data, dosimetric evaluations, and therapeutic results are presented to demonstrate the effective and preferential targeting of 131I-labeled TNT-1 monoclonal antibody within the tumor. In the experimental groups, the dose delivered to the tumor was sufficient to induce clinical regressions in 88% of treated animals, without evidence of toxicity to normal tissues. Complete regressions were obtained in 25% of the mice treated with high dose TNT-1. Microscopic examination of the implantation sites of these mice demonstrated the presence of acute radiation damage and residual keratin-positive tumor cells showing marked evidence of degeneration. Dosimetric data obtained over the 3-week treatment period showed that, unlike control treated mice, which received approximately 500 cGy each week, the experimental animals received increasing doses of radiolabeled antibody with each treatment (averages for weeks 1, 2, and 3: 1066, 2046, and 2476 cGy, respectively). In accordance with these data, enhanced imaging and therapeutic responses were observed with each therapeutic dose in the TNT-1-treated groups, compared with controls. These results indicate that TNT-1 therapy produces an ever expanding population of TNT-1-positive targets in the tumor as a result of the centrifugal killing of adjacent viable tumor cells. To help illustrate these results, a four-compartment model of the dose distribution kinetics of TNT-1 is presented for discussion with respect to the possible application of this method for the imaging and treatment of cancer in
Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure (2004)

Apelin is a novel neuropeptide involved in the regulation of body fluid homeostasis and cardiovascular functions. It acts through a G protein-coupled receptor, the APJ receptor. We studied the structure-activity relationships of apelin at the rat apelin receptor, tagged at its C-terminal end with enhanced green fluorescent protein and stably expressed in CHO cells. We evaluated the potency of N- and C-terminal deleted fragments of K17F to bind with high affinity to the apelin receptor, and to inhibit cAMP production and to induce apelin receptor internalization. We first characterized the internalization and trafficking of the rat apelin receptor. This receptor was internalized via a clathrin-dependent mechanism and our results suggest that receptor trafficking may follow a recycling pathway. We then tried to identify the amino acids of K17F required for apelin activity. The first five N-terminal and the last two C-terminal amino acids of K17F were not essential for apelin binding or the inhibition of cAMP production. However, the full-length sequence of K17F was the most potent inducer of apelin receptor internalization because successive N-terminal amino-acid deletions progressively reduced internalization and the removal of a single amino acid at the C-terminus abolished this process. Finally, the most novel observation of this work is that hypotensive actions of apelin peptides correlate best with the ability of those ligands to internalize. Thus, apelin receptor signaling and endocytosis are functionally dissociated, possibly reflecting the existence of several conformational states of this receptor, stabilized by the binding of different apelin fragments to the apelin receptor.
Coexistence Between Ultra-Wideband Radio and Narrow-Band Wireless LAN Communication Systems—Part I: Modeling and Measurement of UWB Radio Signals in Frequency and Time (2009)

The correct modeling and measurement of ultra-wideband (UWB) radio signal are a critical issue to evaluate the electromagnetic (EM) emission of any communication system based on this technology. In this paper (Part I), UWB radio communication systems based on impulse radio (IR) and multiband orthogonal frequency division multiplex (MB-OFDM) technologies are characterized by simulations and experiments in both frequency and time domains. The EM characteristics of UWB radio are measured by different methods (conducted and radiative) and in different environments (anechoic and reverberation chambers).
ShanghaiGrid: an Information Service Grid: Research Articles (2006)

The goal of the ShanghaiGrid is to provide information services to the people. It aims to construct a metropolitan-area information service infrastructure and establish an open standard for widespread upper-layer applications from both communities and the government. The Information Service Grid Toolkit and a typical application called the Traffic Information Grid are discussed in detail. Copyright © 2005 John Wiley & Sons, Ltd.
Einleitung (1994)

Die vorliegende Studie stellt die Ergebnisse einer empirischen Analyse sozialer Prozesse betrieblichen Wandels vor. Wir knüpfen damit an den ersten Teil unserer Untersuchung über unternehmenskulturelle und technologische Rationalisierungs- und Modernisierungskonzepte an, die wir unter dem Titel „Technik und Interaktion“ veröffentlicht haben. Darin geht es vor allem um die interaktionstheoretische Rekonstruktion eines firmeninternen Technikgeneseprozesses, der Implementation eines CIM-ähnlichen Automatisierungsprojekts in einem Unternehmen der Luft- und Raumfahrtindustrie.
Performance simulation modeling for fast evaluation of pipelined scalar processor by evaluation reuse (2005)

This paper proposes a rapid and accurate evaluation scheme for cycle counts of a pipelined processor using evaluation reuse technique. Since exploration of an optimal processor is a time-consuming task due to large design space, fast evaluation methodology for an architecture is crucial. We introduce the performance simulation model which can evaluate the performance without considering the functional correctness. This model has an FSM-like form and can afford to take all hazard types of pipelined architectures into consideration. The proposed approach is based on the property that an application program, especially multimedia application, has many iterative loops in general. This property invokes many iterative operations in the simulation. Evaluation reuse scheme can alleviate redundantly iterative operations of conventional simulators in the loop. A performance simulator for the pipeline architecture has been developed through which greater speedup has been made compared with other approaches in the evaluation of cycle counts.
An architecture of HMM-based isolated-word speech recognition with tone detection function (2009)

In an architecture of speech recognition for some languages (such as Thai, Chinese, and so on) that tone plays a key role in meaning classification, tone detection function is required in order to guarantee a correct word recognition. This paper proposes an architecture of HMM-based isolated-word speech recognition with tone detection function. In this architecture, tone detection function is added into each computation process of series architecture and each parallel computation of scalable architecture. To evaluate the performance of the proposed method, the experiment is set and performed with 29 Thai words selected from TV remote control commands and 10 Thai indistinct tone classification words. The results reveal 4.94% improvement of accuracy rate for remote control commands and 10.75% for indistinct tone classification words comparing with the conventional architecture.
Recombinant Virus Like Particles as Drug Delivery System (2005)

The drug delivery system described here is based on a virus like particle consisting of the recombinant expressed major capsid protein of Polyomavirus, VP1. Polyoma, a murine virus belonging to the Papovaviridae, forms a non-enveloped icosahedral capsid. These capsids are organized as a double shell composed of three different proteins: VP1,VP2 and VP3. The outer shell of the vision is composed of 360 VP1 molecules arranged as 72 pentamers. These capsids have a diameter of about 50 nm. The VP1 protein acts as a major ligand for certain membrane receptors during virus infection. Furthermore, the N-terminus of the VP1 protein contains a DNA-binding domain and a nuclear localization sequence. The recombinant production of the VP1 protein offers a save way to obtain a highly purified, non pathogenic pharmaceutical excipient. Combining these aspects, VP1 proteins provide a targeting as well as a drug binding site when used as a save drug carrier for gene therapy. Current applications are also including oligonucleotides as well as small molecules as well as vaccines.
Pressing the abdominal aorta to stop uterine bleeding Gauss (Zentr. F. Gyn., 1920, No. 1) (2021)

Used as an ultimum refugium for threatening uterine bleeding after childbirth, the method of elastic body constriction according to Momburg's is not without, as you know, major disadvantages and dangers; the same should be said about the tamponation of the uterine cavity recommended for such cases by Dhgssen. In view of this, Gauss (Zentr. F. Gyn.,. 1920, No. 1) recalls the method of isolated pressing of the abdominal aorta using a special Aderpresse, which he proposed back in 1910.
Investigation of two respiratory monitoring systems used for 4D CT and respiratory gating (2008)

Respiratory gating enables breathing synchronised activation of CT image acquisition and linear accelerator radiation output. Two commercially available respiratory gating systems used for planning and treatment of thoracic and abdominal cancer are investigated. The strain gauged AZ-733V respiratory gating system (Anzai Medical Systems, Tokyo, Japan) was used concurrently with the infrared Real-time Position Management system (Varian Medical Systems, Palo Alto, CA) to measure the respiratory cycle of 15 volunteers. Correlation between systems was measured in six locations and the optimum position of the external surrogates determined based on signal amplitude, reproducibility of breathing waveforms and the coefficient of determination between Anzai and RPM signals. The mean value of R2 between the two systems was found to be 0.611, 0.788 and 0.925 when both markers were positioned at the xiphoid, midway between the xiphoid process and umbilicus, and at the umbilicus respectively. When positioned in separate locations results were varied, R2 values ranging from 0.345-0.965. Results highlighted the importance of external surrogate position to the respiratory signal obtained, and indicated that the external marker position on the chest wall needs to be reproducible between 4D CT scanning and treatment. Recommendations are made that external surrogates must always be positioned at the umbilicus for the most clinically useful scans.\nImage distortion and artifacts were studied using the Anzai AZ-733V respiratory gating system in combination with the Siemens Sensation Open CT scanner. A moving respiratory phantom was constructed and the volumetric accuracy of retrospectively reconstructed 4D CT images for three moving test objects, across five frequencies and four amplitudes of movement was compared. Volumetric accuracy was found to be within 10% for retrospectively reconstructed gated objects moving with a period of 4 s, amplitude 1 cm. Large deviations of 19.4-51.6% from the static volume of the objects were observed in gated images for periods of 3 s or less. Significant distortion and under sampling was observed in gated images of the objects moving with a period of 10 s. Artifacts were related to the partial projection effect and data sufficiency conditions outlined in literature (Keall 2004, Pan 2004, Dinkel 2007).
Multimolecular Analysis of Stable Immunological Synapses Reveals Sustained Recruitment and Sequential Assembly of Signaling Clusters (2013)

The formation of the immunological synapse between T cells and antigen-presenting cells (APC) begins within minutes of contact and can take hours for full T-cell activation. Although early phases of the synapse have been extensively studied for a select number of proteins, later phases have not yet been examined in detail. We studied the signaling network in stable synapses by measuring the simultaneous localization of 25 signaling and structural molecules over 2 h at the level of individual synapses using multi-epitope ligand cartography (MELC). Signaling proteins including phospho(p)ZAP70, pSLP76, pCD3ζ, and pLAT, along with proteins that influence synapse structure such as F-actin, tubulin, CD45, and ICAM-1, were localized in images of synapses and revealed the multidimensional construction of a mature synapse. The construction of the stable synapse included intense early TCR signaling, a phase of recruitment of structural proteins, and a sustained increase in signaling molecules and colocalization of TCR and pLAT signaling clusters in the center of the synapse. Consolidation of TCR and associated proteins resulted in formation of a small number of discrete synaptic microclusters. Development of synapses and cSMAC composition was greatly affected by the absence of Vav1, with an associated loss in PLCγ1 recruitment, pSLP76, and increased CXCR4. Together, these data demonstrate the use of multi-epitope ligand cartography to quantitatively analyze synapse formation and reveal successive recruitment of structural and signaling proteins and sustained phosphorylation at the mature synapse.
Pedestrian Movement Direction Recognition Using Convolutional Neural Networks (2017)

Pedestrian movement direction recognition is an important factor in autonomous driver assistance and security surveillance systems. Pedestrians are the most crucial and fragile moving objects in streets, roads, and events, where thousands of people may gather on a regular basis. People flow analysis on zebra crossings and in shopping centers or events such as demonstrations are a key element to improve safety and to enable autonomous cars to drive in real life environments. This paper focuses on deep learning techniques such as convolutional neural networks (CNN) to achieve a reliable detection of pedestrians moving in a particular direction. We propose a CNN-based technique that leverages current pedestrian detection techniques (histograms of oriented gradients-linSVM) to generate a sum of subtracted frames (flow estimation around the detected pedestrian), which are used as an input for the proposed modified versions of various state-of-the-art CNN networks, such as AlexNet, GoogleNet, and ResNet. Moreover, we have also created a new data set for this purpose, and analyzed the importance of training in a known data set for the neural networks to achieve reliable results.
Postsynaptic localization of PSD-95 is regulated by all three pathways downstream of TrkB signaling (2014)

Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate synaptic plasticity. TrkB triggers three downstream signaling pathways; Phosphatidylinositol 3-kinase (PI3K), Phospholipase Cγ (PLCγ) and Mitogen activated protein kinases/Extracellular signal-regulated kinases (MAPK/ERK). We previously showed two distinct mechanisms whereby BDNF-TrkB pathway controls trafficking of PSD-95, which is the major scaffold at excitatory synapses and is critical for synapse maturation. BDNF activates the PI3K-Akt pathway and regulates synaptic delivery of PSD-95 via vesicular transport (Yoshii and Constantine-Paton, 2007). BDNF-TrkB signaling also triggers PSD-95 palmitoylation and its transport to synapses through the phosphorylation of the palmitoylation enzyme ZDHHC8 by a protein kinase C (PKC; Yoshii etal., 2011). The second study used PKC inhibitors chelerythrine as well as a synthetic zeta inhibitory peptide (ZIP) which was originally designed to block the brain-specific PKC isoform protein kinase Mϖ (PKMϖ). However, recent studies raise concerns about specificity of ZIP. Here, we assessed the contribution of TrkB and its three downstream pathways to the synaptic distribution of endogenous PSD-95 in cultured neurons using chemical and genetic interventions. We confirmed that TrkB, PLC, and PI3K were critical for the postsynaptic distribution of PSD-95. Furthermore, suppression of MAPK/ERK also disrupted PSD-95 expression. Next, we examined the contribution of PKC. While both chelerythrine and ZIP suppressed the postsynaptic localization of PSD-95, RNA interference for PKMϖ did not have a significant effect. This result suggests that the ZIP peptide, widely used as the "specific" PKMϖ antagonist by many investigators may block a PKC variant other than PKMϖ such as PKCλ/ι. Our results indicate that TrkB regulates postsynaptic localization of PSD-95 through all three downstream pathways, but also recommend further work to identify other PKC variants that regulate palmitoylation and synaptic localization of PSD-95.