gebhart/patrepeval huggingface dataset:
Experiencias colaborativas en la formación de estudiantes de periodismo: Press Writing and Communication I y Documentación Informativa (2010)

espanolEn el contexto del EEES, las metodologias utilizadas en el proceso de aprendizaje tienen como objetivo la evaluacion de las competencias que los alumnos adquieren durante su proceso de formacion. El desarrollo de estrategias que permitan la integracion de objetivos docentes es esencial para la construccion del conocimiento y la experiencia colaborativa de estudiantes y profesores. La actividad realizada evaluo las competencias y el desarrollo de habilidades en dos asignaturas del segundo curso del Grado de Periodismo (Press Writing and Communication I y Documentacion Informativa) en la Universidad San Jorge. La actividad integro recursos audiovisuales (la pelicula The Paper), debate en el aula (castellano e ingles) y el uso de recursos tecnologicos (Plataforma en linea) en la actividad autonoma del alumno. El analisis del proceso contemplo la preparacion, el desarrollo y la evaluacion de la actividad desde un enfoque cualitativo y cuantitativo. EnglishIn the European Higher Education Area methodologies are used in the learning process to evaluate competences acquired by the students during their educational process. The development of strategies to integrate teaching objectives are essential to build knowledge and collaborative experiences for students and professors. The activity that was carried out evaluated competences and developed skills in two subjects in the second year of the Journalism Degree Programme (Press Writing and Communication I and Journalistic Research) at San Jorge University. The workshop held in the classroom included preparation prior to the activity, audiovisual resources (The Paper), a debate in the classroom (in Spanish and English) and the use of technological resources (Online platform) in individual work the students did. The analysis of the process contemplated preparation, development and evaluation of the activity from a qualitative and quantitative approach.
An English Perspective on Change in Initial Teacher Education (1995)

Abstract This paper describes the changes which have taken place recently in England with respect to the control, the content and the location of secondary initial teacher education. It identifies ways in which control of initial teacher education has been moved away from higher‐education institutions, which prescribe content more and emphasise competence‐based course requirements, and how the location has moved significantly from the higher‐education institution into the school. Some implications for Australian practice are considered in the context of recent criticism of the current situation.
Review of inhaled iloprost for the control of pulmonary artery hypertension in children (2009)

In the pediatric population, pulmonary hypertension may present as an acute event in the setting of lung or cardiac pathology or as a chronic disease, mainly as idiopathic pulmonary hypertension or associated with congenital heart disease. Recently, new pharmacologic approaches have demonstrated significant efficacy in the management of adults with pulmonary arterial hypertension; these include intravenous epoprostenol, prostacyclin analogs, endothelin receptor antagonists and phosphodiesterase type 5 inhibitors. The same treatment strategies are currently used in children. There are only few reports of the use of inhaled iloprost in pediatrics, only one of which reported the use of chronic inhaled iloprost in a significant number of children. This report showed that 1) the acute pulmonary vasodilator response to inhaled iloprost is equivalent to that of inhaled nitric oxide; 2) acute inhalation of iloprost can induce bronchoconstriction 3) the addition of inhaled iloprost can reduce the need for intravenous prostanoid therapy in some patients; 4) most children tolerated the combination of inhaled iloprost and endothelin receptor antagonist or phosphodiesterase inhibitors; 5) Several patients had clinical deterioration during chronic inhaled iloprost therapy and required rescue therapy with intravenous prostanoids. In this review we will discuss the role of inhaled iloprost in acute and chronic pulmonary hypertension in children.
Datapath layout generation with in-the-cell routing and optimal column resequencing (1991)

The authors describe a new layout style for datapath circuits. Novel features of their datapath layout style are the use of a routing channel inside the bitslice cells and leaving the designer full freedom to define the interconnections between datapath columns, instead of imposing a fixed bus architecture. irregular datapaths are permitted and can be incorporated easily. The columns of the datapath are resequenced such that routing costs are minimal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains (2013)

TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS). Here, we report the characterization of prion-like properties of aggregated TDP-43 prepared from diseased brains. When insoluble TDP-43 from ALS or FTLD-TDP brains was introduced as seeds into SH-SY5Y cells expressing TDP-43, phosphorylated and ubiquitinated TDP-43 was aggregated in a self-templating manner. Immunoblot analyses revealed that the C-terminal fragments of insoluble TDP-43 characteristic of each disease type acted as seeds, inducing seed-dependent aggregation of TDP-43 in these cells. The seeding ability of insoluble TDP-43 was unaffected by proteinase treatment but was abrogated by formic acid. One subtype of TDP-43 aggregate was resistant to boiling treatment. The insoluble fraction from cells harboring TDP-43 aggregates could also trigger intracellular TDP-43 aggregation. These results indicate that insoluble TDP-43 has prion-like properties that may play a role in the progression of TDP-43 proteinopathy.
Metabolic Stability of [<sup>18</sup>F]Fluoroalkylbiphenyls (2004)

The stability of fluoroalkyl groups as a pendent on the phenyl ring was measured in vitro using rat hepatic microsomes and human serum to predict their in vivo stabilities. We have prepared three [<TEX>$^{18}F$</TEX>]fluoroalkyl-biphenyls as the model compounds of fluoroalkyl aromatic compounds to compare the in vitro stabilities. In addition, in vitro stabilities were measured separately using rat hepatic microsomes and human serum at <TEX>$37^{\circ}C$</TEX>. Fluoroethylbiphenyl had similar or slightly superior stability to fluoropropylbiphenyl and these two compounds were much more stable than fluoromethylbiphenyl in vitro.
Computerized tomography in obstructive sleep apnea. Correlation of airway size with physiology during sleep and wakefulness. (1983)

Pathophysiologic changes during sleep in patients with obstructive apnea are often associated with alterations in upper airway function during awake periods. To determine whether these functional changes are related to abnormal airway structure, we performed computerized tomography (CT) in 20 awake patients with obstructive apnea and in 10 control subjects. The CT scan measurements of cross-sectional areas of the nasopharynx, oropharynx, and hypopharynx in apneic patients were significantly reduced (p less than 0.05) compared with those in the control subjects. Sites of obstruction varied, and apparent airway occlusion occurred in 6 patients. Reduced pharyngeal size correlated with increased sleep-disordered breathing rates (p less than 0.05), more severe nocturnal oxygen desaturation (p less than 0.05), and the presence of a saw-tooth pattern of flow-volume curves obtained during awake periods (p less than 0.05). Structural upper airway narrowing is detectable with CT in awake patients with obstructive sleep apnea.
Single-Phase Flow in Meso-Channel Compact Heat Exchangers for Air Conditioning Applications (2009)

Experimental study of the single-phase heat transfer and fluid flow in meso-channels, i.e., between micro-channels and mini-channels, has received continued interest in recent years. The studies have resulted in empirical correlations for various geometries ranging from simple circular pipes to complicated enhanced noncircular channels. However, it is still unclear whether the correlations developed for conventional macro-channels are directly applicable for use in micro-/mini-channels, i.e., hydraulic diameter less than 3 mm, with heat exchanger applications. A few researchers have agreed that similar results may be obtained for the laminar flow regime regardless of the channel size, but no general agreement has been reached for the transitional and turbulent flow regimes yet. In this study, different meso-channel air–liquid compact heat exchangers were evaluated and the experimental results were compared with published empirical correlations. A modified Wilson plot technique was applied to obtain the heat transfer coefficients, and the Fanning equation was used to calculate the pressure drop friction factors. The uncertainty estimates for the measured and calculated parameters were also calculated. The results of this study showed that the well-established heat transfer and pressure drop correlations for the macro-channels are not directly applicable for use in the compact heat exchangers with meso-channels.
NONALCOHOLIC FATTY LIVER DISEASE IN MENOPAUSAL WOMEN (2013)

In conclusion this data suggests elevated prevalence of NAFLD in postmenopausal women; negative association of hormone replacement therapy and NAFLD.
Role of Cellulose Ether Polymers on Ibuprofen Release from Matrix Tablets (2005)

Cellulose derivatives are the most frequently used polymers in formulations of pharmaceutical products for controlled drug delivery. The main aim of the present work was to evaluate the effect of different cellulose substitutions on the release rate of ibuprofen (IBP) from hydrophilic matrix tablets. Thus, the release mechanism of IBP with methylcellulose (MC25), hydroxypropylcellulose (HPC), and hydroxypropylmethylcellulose (HPMC K15M or K100M) was studied. In addition, the influence of the diluents lactose monohydrate (LAC) and beta-cyclodextrin (beta-CD) was evaluated. Distinct test formulations were prepared containing: 57.14% of IBP, 20.00% of polymer, 20.29% of diluent, 1.71% of talc lubricants, and 0.86% of magnesium stearate as lubricants. Although non-negligible drug-excipient interactions were detected from DSC studies, these were found not to constitute an incompatibility effect. Tablets were examined for their drug content, weight uniformity, hardness, thickness, tensile strength, friability, porosity, swelling, and dissolution performance. Polymers MC25 and HPC were found to be unsuitable for the preparation of this kind of solid dosage form, while HPMC K15M and K100M showed to be advantageous. Dissolution parameters such as the area under the dissolution curve (AUC), the dissolution efficiency (DE(20 h)), dissolution time (t 50%), and mean dissolution time (MDT) were calculated for all the formulations, and the highest MDT values were obtained with HPMC indicating that a higher value of MDT signifies a higher drug retarding ability of the polymer and vice-versa. The analysis of the drug release data was performed in the light of distinct kinetic mathematical models-Kosmeyer-Peppas, Higuchi, zero-, and first-order. The release process was also found to be slightly influenced by the kind of diluent used.
Early Region 4 Modulates Adenovirus DNA Replication by Two Genetically Separable Mechanisms (1997)

Three viral proteins, all products of early region 2 (E2), participate directly in adenovirus DNA replication. Three products of early region 4 (E4) also affect viral DNA synthesis: the product of E4 ORF4 inhibits viral DNA accumulation, while the products of E4 ORFs 3 and 6 antagonize that effect of ORF4 expression. Because no E4 products are required for DNA synthesis, these proteins probably act indirectly. The E4 ORF3, 4, and 6 proteins all participate in aspects of the regulation of viral gene expression. To determine whether they modulate DNA replication by effects on expression of viral replication proteins, we examined E2 expression in E4 mutant-infected cells. In cells infected by ORF3-, 6- mutants, expression of ORF4 substantially depressed the steady-state levels of replication proteins and E2 mRNAs, reduced E2 transcription rates, and profoundly inhibited viral DNA replication. Thus, in the absence of E4 ORFs 3 and 6, ORF4 acts as a transcriptional regulator of E2 expression, and reduced replication protein levels largely account for the inhibition of DNA replication by ORF4. Cells infected by viruses that express ORFs 3 and 6 in addition to ORF4 accumulated much larger quantities of viral DNA than did cells infected by the ORF3-, 6-, 4+ mutant. Increased DNA accumulation was not accompanied by a comparable increase in E2 expression. Therefore, the ORF3 and 6 products counteract the ORF4-induced reduction of DNA replication by a mechanism other than reversing the inhibitory effect of ORF4 on E2 expression. The effect of ORF4 on E2 expression is consistent with its ability to regulate levels of the transcription factor AP-1 (Müller et al., 1992, J. Virol. 66, 5867-5878); the mechanism by which ORFs 3 and 6 enhance replication is unknown.
Self-Curing Decoupling Technique for Two Inverted-F Antennas With Capacitive Loads (2018)

A new concept named the self-curing decoupling technique is proposed for the first time to reduce the mutual coupling between two closely located inverted-F antennas (IFAs). The decoupling technique only requires a capacitive load on the shorting arm of each coupled IFA without connecting a circuitry or inserting a physical structure between the two coupled antennas. The capacitive load occupies very little space and is frequency-insensitive; therefore, the decoupling technique is a very favorable choice for low-frequency applications. Network analysis is presented to mathematically justify the working mechanism and to provide a design guideline. Several practical cases of two IFAs situated at different positions on the periphery of a PCB board are studied. The experimental results show that with the decoupling technique, significant improvements in the port isolation (from 10 to 20 dB), antenna correlation coefficient (from 0.25 to 0.05), multiplexing efficiency (from 46% to 60%), and above all the system throughput (1.2 and 0.8 dB power saving in Urban Microcell and Urban Macrocell channels, respectively) can be obtained.
Automated Measurement of Tear Film Dynamics and Lipid Layer Thickness for Assessment of Non-Sjögren Dry Eye Syndrome With Meibomian Gland Dysfunction (2016)

Automated noninvasive measurements using an advanced corneal topographer and LLT measured with an ocular surface interferometer can be alternatives to conventional methods to evaluate tear conditions on the ocular surface; the former device can provide information about conformational MG changes in NSDES with MGD.
Regulating survival and development in the retina: key roles for simple sphingolipids (2010)

Many sphingolipids have key functions in the regulation of crucial cellular processes. Ceramide (Cer) and sphingosine (Sph) induce growth arrest and cell death in multiple situations of cellular stress. On the contrary, sphingosine-1-phosphate (S1P), the product of Sph phosphorylation, promotes proliferation, differentiation, and survival in different cell systems. This review summarizes the roles of these simple sphingolipids in different tissues and then analyzes their possible functions in the retina. Alterations in proliferation, neovascularization, differentiation, and cell death are critical in major retina diseases and collective evidence points to a role for sphingolipids in these processes. Cer induces inflammation and apoptosis in endothelial and retinal pigmented epithelium cells, leading to several retinopathies. S1P can prevent this death but also promotes cell proliferation that might lead to neovascularization and fibrosis. Recent data support Cer and Sph as crucial mediators in the induction of photoreceptor apoptosis in diverse models of oxidative damage and neurodegeneration, and suggest that regulating their metabolism can prevent this death. New evidence proposes a central role for S1P controlling photoreceptor survival and differentiation. Finally, this review discusses the ability of trophic factors to regulate sphingolipid metabolism and transactivate S1P signaling pathways to control survival and development in retina photoreceptors.
A Single Surgeon??s 12-Year Experience with Tissue Expander/Implant Breast Reconstruction: Part II. An Analysis of Long-Term Complications, Aesthetic Outcomes, and Patient Satisfaction (2006)

Tissue expander/implant reconstruction yields good to excellent long-term aesthetic results in the majority of patients, and overall patient satisfaction remains high. Bilateral reconstructions have higher overall aesthetic grades. Reconstruction may be performed in patients with larger-volume breasts with satisfactory cosmesis. Successful outcomes are possible in patients who receive chest wall irradiation.
Reservoir computing based on delay-dynamical systems (2012)

&#091;eng&#093; Today, except for mathematical operations, our brain functions much faster and more efficient than any supercomputer. It is precisely this form of information processing in neural networks that inspires researchers to create systems that mimic the brain’s information processing capabilities. In this thesis we propose a novel approach to implement these alternative computer architectures, based on delayed feedback. We show that one single nonlinear node with delayed feedback can replace a large network of nonlinear nodes. First we numerically investigate the architecture and performance of delayed feedback systems as information processing units. Then we elaborate on electronic and opto-electronic implementations of the concept. Next to evaluating their performance for standard benchmarks, we also study task independent properties of the system, extracting information on how to further improve the initial scheme. Finally, some simple modifications are suggested, yielding improvements in terms of speed or performance
Neighboring Group Participation of the Indole Nucleus:  An Unusual DAST-Mediated Rearrangement Reaction (2000)

A rearrangement reaction involving the indole nucleus was investigated using stereochemical markers and low-temperature NMR experiments. Treatment of (3S, 4S)-3-hydroxy-4-(2-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid benzyl ester (>90% ee) with diethylaminosulfur trifluoride gave stereospecifically (3S, 4S)-4-fluoro-3-(2-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid benzyl ester (>90% ee) with complete regioselectivity. The initial formation of a reactive spirocyclopropyl-3H-indole intermediate is believed to be responsible for the stereo- and regiochemical outcome of the reaction.
An Amylose Antiparallel Double Helix at Atomic Resolution (1987)

In the crystal structure of the polyiodide complex (p-nitrophenyl-alpha-maltohexaose(2)) . Ba(I(3))(2) . 22H(2)O, the maltohexaose units form an antiparallel, left-handed double helix with O-2 ... O-3 and O-6 ... O-6 hydrogen bonding and a central cavity that encloses two triiodide units. This structure contrasts with the parallel, left-handed double helix with no central cavity proposed for the A-and B-starch helix and the left-handed single helix in V-amylose and may be relevant for the stabilization of glycogen Structure.
Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide (1998)

The calcitonin/calcitonin gene-related peptide (CT/CGRP) gene is one of the earliest studied examples of alternative RNA processing. The regulatory mechanisms controlling this event are poorly understood. We have identified and characterized an intron element residing in intron 4 of the human CT/CGRP gene. This intron element functions to enhance polyadenylation of an embedded alternative 3'-terminal exon within the CT/CGRP gene and is potentially involved in tissue-specific regulation of CT/CGRP RNA processing.
Molecular cloning and characterization of two voltage‐gated K <sup>+</sup> channel cDNAs from human ventricle (1991)

K+ channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. In the heart these channels are responsible for the rapid repolarizing phases of the action potential and are the targets of several antiarrhythmic drugs. Full-length cDNA clones were isolated from human ventricular libraries that encode two voltage-gated K+ channels. These two cDNAs, designated HK1 and HK2, encode proteins of 653 and 605 amino acids, respectively. HK1 is the human equivalent (98% identity) of an inactivating K+ channel previously described in rat heart (RHK1) whereas the HK2 channel is 86% identical to a cloned rat brain K+ channel (Kv1). The only amino acid sequence identity (72%) between HK1 and HK2 is within the central region containing the membrane spanning domains. Northern blot analysis of human mRNA indicated that HK1 is slightly more abundant in ventricle than atrium whereas HK2 is much more abundant in atrium relative to ventricle. Both channel transcripts are present in ventricle at levels equivalent to voltage-gated Na+ channels. Analysis of the gene encoding HK1 suggests the coding sequence is intronless and is represented once in the human genome.
Digital spiral imaging (2005)

A major application of optics is imaging all types of structural, physical, chemical and biological features of matter. Techniques based on most known properties of light have been developed over the years to remotely acquire information about such features. They include the spin angular momentum, encoded in the polarization, but not yet the orbital angular momentum encoded in its spiral spectrum. Here we put forward the potential of such spiral spectra. In particular, we use several canonical examples to show how the orbital angular momentum spectra of a light beam can be used to image a variety of intrinsic and extrinsic properties encoded, e.g., in phase and amplitude gradients, dislocations or delays.
Association of Sound to Motion in Video using Perceptual Organization (2006)

Traditionally, video surveillance has mostly made use of visual data. However, in light of the new behavioral and physiological studies which demonstrated the existence of cross modality effects in human perception, similar cues are being used to develop a surveillance system based on both audio and visual data. Human beings can easily associate a particular sound to an object in the surrounding. Drawing from such studies, we demonstrate a technique by which we can isolate concurrent audio and video events and associate them based on perceptual grouping principles. Simple cues from both audio and video suffice to make this association. By representing audio in the pitch-time domain, we can use image processing algorithms such as line detection to extract elementary audio events. These events are then grouped using Gestalt principles of similarity and proximity into appropriate auditory events. Properties such as time of occurrence and periodicity are easily calculated from these groups. In video, we extract motion and shape periodicities. By comparing all the periodicities in audio and video using a simple index we can easily associate audio to video