gebhart/patrepeval huggingface dataset:
Leukocyte migration inhibition test in children with cow milk allergy (1987)

The usefulness of the leukocyte migration inhibition factor (LIF) test to detect cow milk (CM) hypersensitivity was studied in 40 children with suspected allergy to CM. Hypersensitivity was carefully investigated by oral milk challenges, which gave a final confirmation of cow milk hypersensitivity in 12 subjects, and excluded it in the remaining 28 subjects. Leukocyte migration inhibition was measured using beta-lactoglobulin (BLG), alpha-lactalbumin (ALA), alpha-casein (ACA) and bovine serum albumin (BSA) as antigens. IgA and IgG antibodies to these antigens were measured by an enzyme-linked immunosorbent assay, and IgE antibodies to these antigens and to CM by radioallergosorbent test (RAST). Skin prick test with CM was performed in 38 subjects, and with BLG, ALA, ACA and BSA in 29 subjects. Leukocyte migration was more often inhibited by cow milk antigens in the CM challenge positive (CM+) subjects than in the challenge negative (CM-) subjects. Of the specific milk antigens, ALA was the most potent inhibitor, and gave a positive LIF test result in all CM+ subjects, and significantly (P less than 0.02) less often (15/24) in CM- subjects. Also in the skin prick test and RAST, ALA gave positive results more often than the other milk antigens. BLG, ACA and BSA had an inhibiting effect on leukocyte migration, but the difference between the CM+ and CM- subjects was not statistically significant. Two of the 12 CM+ subjects had no demonstrable IgE antibodies to CM proteins; both of them, however, had a positive LIF test with at least one of the CM antigens.(ABSTRACT TRUNCATED AT 250 WORDS)
Hybrid silicon-polymer platform for self-locking and self-deploying origami (2013)

This Letter reports the demonstration of self-locking and self-deploying functions of an origami platform based on silicon island arrays. The silicon islands serve as the rigid part of the origami and are able to integrate complementary metal–oxide–semiconductor circuits, microelectromechanical systems, and other functional components. The creases of the origami, which are the flexible connectors among silicon islands, are realized by parylene balloons filled with paraffin wax. Metal heaters are integrated on the balloons to control the solid/liquid phases of the wax on-chip. Prototypes of such an origami platform have been fabricated. By turning on and off the heaters at different states of the origami, self-locking and self-deploying features have been demonstrated.
The evolution of wind power integration studies: Past, present, and future (2009)

The rapid growth of wind power as a generation resource in the past decade has given many utilities and Regional Transmission Organizations (RTO) concerns due to its unconventional characteristics. Because of these concerns, many of these entities have initiated studies that evaluate the feasibility of large amounts of wind power onto their system and the operational impacts present. This paper will discuss some of the past major studies, mostly focusing on the United States, and the basic methodologies that were used during these studies. The paper will also review many of the different results and conclusions of the studies and discuss how they have helped the power industry as a whole. Lastly, the authors will attempt to share their ideas on some of the limitations of the current and past integration studies, and some insight on how these may be evolving in the future.
Characterization of antibodies to the structural polypeptides of HGSAg: evidence for subtype-specific determinants. (1976)

Antisera prepared in guinea pigs to the structural polypeptides of HBAAg/adw and HBSAg/ayw were examined by a modified passive hemagglutination assay for antibodies to the subtype-specific d and y determinants. All of the isolated polypeptide fractions stimulated antibodies to both group specific and subtype-specific antigens of the native HBSAg particle from which they were derived. These data indicate that the polypeptides have similarities in their immunochemical structure.
Large-scale parallelization of partial evaluations in evolutionary algorithms for real-world problems (2018)

The importance and potential of Gray-Box Optimization (GBO) with evolutionary algorithms is becoming increasingly clear lately, both for benchmark and real-world problems. We consider the GBO setting where partial evaluations are possible, meaning that sub-functions of the evaluation function are known and can be exploited to improve optimization efficiency. In this paper, we show that the efficiency of GBO can be greatly improved through large-scale parallelism, exploiting the fact that each evaluation function requires the calculation of a number of independent sub-functions. This is especially interesting for real-world problems where often the majority of the computational effort is spent on the evaluation function. Moreover, we show how the best parallelization technique largely depends on factors including the number of sub-functions and their required computation time, revealing that for different parts of the optimization the best parallelization technique should be selected based on these factors. As an illustration, we show how large-scale parallelization can be applied to optimization of high-dose-rate brachytherapy treatment plans for prostate cancer. We find that use of a modern Graphics Processing Unit (GPU) was the most efficient parallelization technique in all realistic scenarios, leading to substantial speed-ups up to a factor of 73.
An introduction to spatially-coupled codes via practical examples (2014)

This paper uses examples to illustrate the ongoing transition in spatially-coupled coding from theory to practice. In the first example, we find that spatially-coupled codes have already been implemented by two different companies for 100 Gb/s optical communications. Both systems use variants of braided block codes, which were introduced even before the term spatial coupling. In the second example, we discuss the multiple-access channel and observe that some gains from spatial coupling were being realized in cellular base stations as early as 2007. Finally, we discuss some open questions regarding spatially-coupled codes.
Anomalous coronary arteries coursing between the aorta and pulmonary trunk: clinical indications for coronary artery bypass (1991)

Coronary arteries of anomalous origin with subsequent coursing between the aorta and pulmonary trunk can cause ischaemia, infarction or sudden death. However, reports of surgical correction are sparse due to the rarity of ante-mortem diagnosis. We report two cases in which symptoms were related to anomalous origin of a non-atherosclerotic coronary artery. Surgical repair was performed to prevent sudden death or recurrent ischaemia.
Stereoselective, nonenzymic, intramolecular transfer of amino acids (1991)

Biological systems synthesize proteins with an almost exclusive use of L-amino acids and virtually none of the D isomer. There has been no satisfactory explanation for the origin of this use of the L isomer. Research presented here shows that at pH 5, transfer of phenylalanine from the adenylate anhydride to ester occurs and is 95-97% efficient for the L isomer and only about 50% efficient for the D isomer. The origin of the use of the L isomer, given D-ribose nucleotides, may be based in part on this stereoselectivity.
Physicochemical Behavior of Homogeneous Series of Acetylated Chitosans in Aqueous Solution:  Role of Various Structural Parameters (2004)

Physicochemical properties of four different homogeneous series of chitosans with degrees of acetylation (DA) and weight-average degrees of polymerization (DP(w)) ranging from 0 to 70% and 650 to 2600, respectively, were characterized in an ammonium acetate buffer (pH 4.5). Then, the intrinsic viscosity ([eta](0)), the root-mean-square z-average of the gyration radius (R(G,z)), and the second virial coefficient (A(2)) were studied by viscometry and static light scattering. The conformation of chitosan, according to DA and DP(w), was highlighted through the variations of alpha and nu parameters, deduced from the scale laws [eta](0) = K(w)and R(G,z) = K', respectively, and the total persistence length (L(p,tot)). In relation with the different behaviors of chitosan in solution, the conformation varied according to two distinct domains versus DA with a transition range in between. Then, (i) for DA < 25%, chitosan exhibited a flexible conformation; (ii) a transition domain for 25 < DA < 50%, where the chitosan conformation became slightly stiffer and, (iii) for DA > 50%, on increasing DP(w) and DA, the participation of the excluded volume effect became preponderant and counterbalanced the depletion of the chains by steric effects and long-distance interactions. It was also highlighted that below and beyond a critical DP(w,c) (ranging from 1 300 to 1 800 for DAs from 70 to 0%, respectively) the flexibility of chitosan chains markedly increased then decreased (for DA > 50%) or became more or less constant (DA < 50%). All the conformations of chitosan with regards to DA and DP(w) were described in terms of short-distance interactions and excluded volume effect.
Histological effects of local microwave hyperthermia in prostatic cancer (1991)

Recent investigations have shown that hyperthermia can reduce the volume of the prostate and improve local symptoms in patients with carcinoma of the prostate. Histological examinations of the effect of hyperthermia on prostatic cancer tissue, however, have not been performed systematically until now. Thus, we initiated a study to investigate the effects of heat on prostatic cancer as a prerequisite for further clinical trials on hyperthermia as treatment for prostatic cancer. Twenty patients with untreated prostatic cancer underwent local hyperthermia (915 MHz), each receiving four sessions of 60 min each. The intraprostatic temperature was 42-43 degrees C. Histological specimens of the prostate were taken before the treatment and 1-2 weeks after the last hyperthermia session. Hyperthermia produced hyperaemic alterations of the prostatic stroma and a diffuse oedema with interstitial lymphoplasmacellular infiltration. Definite signs of tumour cell necrosis, however, could not be seen in any of the patients. Hence the shrinkage of prostatic tumours described earlier cannot be explained by histologically proven tumour cell destruction. Thus hyperthermia is not adequate as a single treatment for prostatic cancer. Hyperthermia may, however, be useful as part of integrated therapy regimens together with cytostatic or hormonal agents and radiotherapy because of hyperaemic, chemo- and radiosensitizing effects.
[Effects of adipose-derived stem cell transplantation on the angiogenesis and the expression of bFGF and VEGF in the brain post focal cerebral ischemia in rats]. (2008)

The transplantation of ADSC can promote the revascularization of cerebral ischemia in rats partly by enhancing bFGF and VEGF synthesis in brain.
Computer Architectures for Artificial Intelligence Processing (1987)

This article assesses different architectural approaches to the design of computers for artificial intelligence (AI) applications. The authors provide a classification scheme that highlights the relationship between the application domains and hardware realization of AI-oriented computer systems, as well as a comparison of AI machines and numerical computers. The emphasis is on three architectural classes: multiprocessors that support interactive MIMD (multiple-instruction stream and multiple-data stream) operations through a shared memory space; multicomputers that support multiple SISD (single-instruction stream and single-data stream) operations by means of message passing among distributed processors with local memories; and multipurpose computers consisting of a large number of fine-grain processor-memory nodes operating in an SIMD (single-instruction stream and multiple-data stream), a multiple SIMD, or an MIMD fashion.
Polarization selective beam shaping using nanoscale dielectric metasurfaces (2015)

Metasurfaces consisting of ultrathin nanostructures are utilized to control the properties of light including its phase, amplitude and polarization. Hereby, we demonstrate the capability of such structures to perform arbitrary polarization selective beam shaping using dielectric nanoscale metasurfaces implemented in silicon. By illuminating the structure with right handed circular polarization we reconstruct a desired image. When switching the polarization into its orthogonal state, we obtain the reconstruction of a different image. This demonstration shows the potential of using dielectric metasurfaces for high efficiency beam shaping applications in general, and specifically for polarization coded beam shaping.
Peer-Based Approach for Analytical Procedures (2006)

This study extends the existing research in analytical procedures by allowing for learning from contemporaneous information transfers among peer companies. We introduce an approach for selecting peers for each client and perform tests to examine the contribution of peers' information to the performance of analytical procedures. We find that peer data are imperfect substitutions for contemporaneous firmspecific variables when such variables are not in error. However, we observe that contemporaneous peer specific data are especially beneficial when coordinated errors exist in multiple accounts. We demonstrate that when errors are seeded into two contemporaneous accounts, peer models perform better at detecting errors. We also find that fast-changing companies experience inferior prediction and error detection accuracy, and that larger companies experience more accurate prediction, lower Type II errors, and higher Type I errors. Additionally, we observe that significant improvements in the performance of analytical procedures are associated with larger clients indicating that auditors of larger companies can potentially benefit more from the use of peer data.
Robust H-infinity kinematic control of manipulator robots using dual quaternion algebra. (2018)

This paper proposes a robust dual-quaternion based H-infinity task-space kinematic controller for robot manipulators. To address the manipulator liability to modeling errors, uncertainties, exogenous disturbances, and their influence upon the kinematics of the end-effector pose, we adapt H-infinity techniques\textemdash suitable only for additive noises\textemdash to unit dual quaternions. The noise to error attenuation within the H-infinity framework has the additional advantage of casting aside requirements concerning noise distributions, which are significantly hard to characterize within the group of rigid-body transformations. Using dual quaternion algebra, we provide a connection between performance effects over the end-effector trajectory and different sources of uncertainties and disturbances while satisfying attenuation requirements with minimum instantaneous control effort. The result is an easy-to-implement closed-form H-infinity control design criterion. The performance of the proposed strategy is evaluated within different realistic simulated scenarios and validated through real experiments.
Effects of nonlinear transmit amplifiers in smart antennas in wireless systems (1999)

The use of array antennas in mobile telecommunication systems has proven to increase the spectral efficiency of the system. However, the use of an N element array antenna at the basestation site implies that the amount of radio hardware must be increased N -fold. This will make basestations larger, more expensive and more power consuming. Much effort must be put into combine functionality as amplification, using a multicarrier amplifier (MCPA), capable to amplify a number of signals with different carrier frequencies in a single device. In this study we investigate by measurements and simulations the effects of a nonlinear MCPA in the downlink for a cellular system. The nonlinearity will introduce intermodulation distortion and also decrease the null-depth of the beamformer. This will have an impact on the carrier-to-interference ratio of the mobiles in the system. The simulations gives the CDF of the received carrier-to-interference ratio of the mobiles, which can be used in link bud...
Effects of Chlorophyll and Chlorophyllin on Low-Dose Aflatoxin B1 Pharmacokinetics in Human Volunteers (2009)

Chlorophyll (Chla) and chlorophyllin (CHL) were shown previously to reduce carcinogen bioavailability, biomarker damage, and tumorigenicity in trout and rats. These findings were partially extended to humans, where CHL reduced excretion of aflatoxin B(1) (AFB(1))-DNA repair products in Chinese unavoidably exposed to dietary AFB(1). However, neither AFB(1) pharmacokinetics nor Chla effects were examined. We conducted an unblinded crossover study to establish AFB(1) pharmacokinetic parameters among four human volunteers, and to explore possible effects of CHL or Chla cotreatment in three of those volunteers. For protocol 1, fasted subjects received an Institutional Review Board-approved dose of 14C-AFB(1) (30 ng, 5 nCi) by capsule with 100 mL water, followed by normal eating and drinking after 2 hours. Blood and cumulative urine samples were collected over 72 hours, and 14C- AFB(1) equivalents were determined by accelerator mass spectrometry. Protocols 2 and 3 were similar except capsules also contained 150 mg of purified Chla or CHL, respectively. Protocols were repeated thrice for each volunteer. The study revealed rapid human AFB(1) uptake (plasma k(a), 5.05 + or - 1.10 h(-1); T(max), 1.0 hour) and urinary elimination (95% complete by 24 hours) kinetics. Chla and CHL treatment each significantly impeded AFB(1) absorption and reduced Cmax and AUCs (plasma and urine) in one or more subjects. These initial results provide AFB(1) pharmacokinetic parameters previously unavailable for humans, and suggest that Chla or CHL co-consumption may limit the bioavailability of ingested aflatoxin in humans, as they do in animal models.
Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism (2004)

The transcriptional regulation of several dozen genes in response to low oxygen tension is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1alpha and HIF-1beta. In the HIF-1alpha-deficient human leukemic cell line, Z-33, exposed to mild (8% O(2)) or severe (1% O(2)) hypoxia, we found significant upregulation of two related heterogenous nuclear ribonucleoproteins, RNA-binding motif protein 3 (RBM3) and cold inducible RNA-binding protein (CIRP), which are highly conserved cold stress proteins with RNA-binding properties. Hypoxia also induced upregulation of RBM3 and CIRP in the murine HIF-1beta-deficient cell line, Hepa-1 c4. In various HIF-1 competent cells, RBM3 and CIRP were induced by moderate hypothermia (32 degrees C) but hypothermia was ineffective in increasing HIF-1alpha or vascular endothelial growth factor (VEGF), a known HIF-1 target. In contrast, iron chelators induced VEGF but not RBM3 or CIRP. The RBM3 and CIRP mRNA increase after hypoxia was inhibited by actinomycin-D, and in vitro nuclear run-on assays demonstrated specific increases in RBM3 and CIRP mRNA after hypoxia, which suggests that regulation takes place at the level of gene transcription. Hypoxia-induced RBM3 or CIRP transcription was inhibited by the respiratory chain inhibitors NaN(3) and cyanide in a dose-dependent fashion. However, cells depleted of mitochondria were still able to upregulate RBM3 and CIRP in response to hypoxia. Thus, RBM3 and CIRP are adaptatively expressed in response to hypoxia by a mechanism that involves neither HIF-1 nor mitochondria.
Corneodesmosin: Structure, Function and Involvement in Pathophysiology (2010)

Corneodesmosin (CDSN) was identified in the early 90 th by raising monoclonal antibodies against human plantar stratum corneum. It is a protein specific to desmosomes that will undergo transformation into corneodesmosomes, i.e. in man, desmosomes of the epidermis, of the three epithelial layers of the inner root sheath of the hair follicles and of the hard palate epithelium. After its secretion by granular keratinocytes via the lamellar bodies, CDSN is incorporated into the desmoglea of the desmosomes shortly before their transformation into corneodesmosomes. CDSN displays adhesive properties, mostly attributable to its N-terminal glycine-rich domain, and is sequentially proteolyzed as corneocytes migrate towards the skin surface. The recent inactivation of Cdsn in mice induced a lethal epidermal barrier disruption and hair follicle degeneration related to desmosome dysfunction, confirming the essential role of the protein in epidermis and hair follicle integrity. CDSN CDSN is located on chromosome 6, in the major psoriasis susceptibility locus PSORS1. Intriguingly, the only monogenic disease identified so far associated with nonsense mutations in CDSN , leading to the formation of a truncated protein, is a rare autosomal dominant disease, hypotrichosis simplex of the scalp. In this review, we expose data from the discovery of the protein to the most recent findings related to the relationship between its structure and function. In particular, the important benefits of mouse models and human diseases for the comprehension of CDSN role in the epidermis and hair follicles are reported in details.
Granulocyte Macrophage Colony-stimulating Factor Signaling and Proteasome Inhibition Delay Neutrophil Apoptosis by Increasing the Stability of Mcl-1 (2004)

Human neutrophils normally have a very short half-life and die by apoptosis. Cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) can delay this apoptosis via increases in the cellular levels of Mcl-1, an anti-apoptotic protein of the Bcl-2 family with a rapid turnover rate. Here we have shown that inhibition of the proteasome (a) decreases the rate of Mcl-1 turnover within neutrophils and (b) significantly delays apoptosis. This led us to determine whether GM-CSF could enhance neutrophil survival by altering the rate of Mcl-1 turnover. Addition of GM-CSF to neutrophils enhanced Mcl-1 stability and delayed apoptosis by signaling pathways requiring PI3K/Akt and p44/42 Erk/Mek, because inhibitors of these pathways completely abrogated the GM-CSF-mediated effect on both Mcl-1 stability and apoptosis delay. Conversely, induction of Mcl-1 hyperphosphorylation by the phosphatase inhibitor, okadaic acid, significantly accelerated both Mcl-1 turnover and apoptosis. Neither the calpain inhibitor, carbobenzoxy-valinyl-phenylalaninal, nor the pan caspase inhibitor, benzyloxycarbonyl-VAD-fluoromethylketone, had any effect on Mcl-1 stability under these conditions. These observations indicate that profound changes in the rate of neutrophil apoptosis following cytokine signaling occur via dynamic changes in the rate of Mcl-1 turnover via the proteasome.