gebhart/patrepeval huggingface dataset:
Advances in targeted therapy of T-cell acute lymphoblastic leukemia (2015)

T-cell acute lymphoblastic leukemia (T-ALL) is a malignant invasive disease which has high rate of relapse. Its molecular characterization and prognosis are characterized as high level of heterogeneity. With aggressive combined chemotheapy and hematopoietic stem cell transplantation (HSCT) applied to clinical , the prognosis of T-ALL has been improved, but the efficacy is not ideal. Therefore, further studies of T-ALL pathogenesis and explore new targeted therapy are of great significance for improving the efficacy of T-ALL. With advances in the molecular characterization of T-ALL, a mumber of new treatment targets were gradually discovered. This article reviews literature on the novel targets of T-ALL therapy.


Key words: 
Leukemia, T-cell; Molecular targeted therapy; Receptor, Notch1; Phosphatidylinositol 3-kinase; Cyclin D; Mammalian target of rapamycin; Bromodomain
Characteristics of coils wound with mono and multifilamentary Bi-2212/Ag from 4 to 80 K (1996)

Many small coils wound with Bismuth based conductor have been manufactured with the Wind and React technique in solenoid shape. The construction of the coils has been integrated with an experimental investigation of the effect of curvature radius on the critical current and of the influence of different insulation materials (braids of quartz and of different ceramics) on the characteristics of the conductor and of the winding. A variety of conductor lay-out have been tested: Bi-2212/Ag with mono and multifilament design, pure silver or Ag-alloy as stabilizer. The influence of different heat treatment conditions-temperature, ramp rate and atmosphere-on the conductor and on the coils performances is presented. The performances of the coils, wound with conductor length from 2 to 36 m, are compared with respect to the short sample critical currents at 4.2 and 77 K and the measurements of the irreversibility lines are discussed. In few coils I/sub c/ is 50% of the short sample value, reaching 80% in the best case.
Degradable and highly porous polyesterurethane foam as biomaterial: Effects and phagocytosis of degradation products in osteoblasts (1998)

Recently, a new class of biodegradable PHB-based polyesterurethane (DegraPol/btc) has been prepared and found to exhibit favorable cell and tissue compatibility. The present study has been designed to evaluate the response of primary isolated rat tibia osteoblasts to small crystalline particles of short-chain poly[(R)-3-hydroxybutyric acid] (PHB-P diameter: 2-20 microm), of fluorescent-labeled analogs (DPHP-P), and of lysine methyl ester as possible degradation products of DegraPol/btc. Observations made using confocal microscopy clearly indicate that osteoblasts have the capability of taking up PHB-P particles. Although in single-cell analysis the number of DPHB-P-positive osteoblasts gradually increased up to 16 days, the fluorescence intensity per osteoblast increased only during the first 4 h after DPHB-P incubation, and then it retained the 4 h level up to 16 days. No significant change in the production levels of collagen type I and osteocalcin was detectable after treatment with low concentrations of PHB-P for up to 32 days. In contrast, a time- and dose-dependent alteration of the alkaline phosphatase (ALP) activity was found. Maximal activity was measured after 4 days of treatment with 2 microg of PHB-P/mL (170% of control cells). Rat peritoneal macrophages co-cultured with osteoblasts in a transwell culture system mimicked the observed PHB-P induced ALP elevation. Therefore, the PHB-P-induced ALP increase could be the result of direct or indirect stimulation of osteoblasts, possibly via soluble factors produced by contaminating osteoclasts. Taken collectively, the data demonstrate that osteoblasts are capable of phagocytosing PHB-P and that this process is accompanied at low PHB-P concentrations by dose- and time-dependent alteration of alkaline phosphatase activity but not of collagen type I or osteocalcin.
Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: a preliminary study (2000)

Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: a preliminary study
3D Printing of Polymer Nanocomposites via Stereolithography (2017)

Additive manufacturing (AM) is still underutilized as an industrial process, but is quickly gaining momentum with the development of innovative techniques and materials for various applications. In particular, stereolithography (SLA) is now shifting from rapid prototyping to rapid manufacturing, but is facing challenges in parts performance and printing speed, among others. This review discusses the application of SLA for polymer nanocomposites fabrication to show the technology's potential in increasing the applicability of current SLA‐printed parts. Photopolymerization chemistry, nanocomposite preparation, and applications in various industries are also explained to provide a comprehensive picture of the current and future capabilities of the technique and materials involved. image
Pentostatin: An Adenosine Deaminase Inhibitor for the Treatment of Hairy Cell Leukemia (1992)

Pentostatin is a purine analog that inhibits adenosine deaminase, a key enzyme necessary for purine salvage. Pentostatin has received labeling approval for the treatment of HCL refractory to a minimum of three to six months of treatment with interferon alfa. Based on current data, pentostatin will be a useful addition to the therapeutic agents presently available to patients with HCL. Ongoing trials are evaluating the effectiveness of pentostatin as first-line therapy for patients with HCL.
Progression From Newly Acquired Impaired Fasting Glusose to Type 2 Diabetes (2007)

To our knowledge, these are the first estimates of diabetes incidence from a clinical care setting when the date of IFG onset is approximately known under the new criterion for IFG. The older criterion was more predictive of diabetes development. Many newly identified IFG patients progress to diabetes in <3 years, which is the currently recommended screening interval.
Skin and nail infections due to <i>Fusarium oxysporum</i> in Tuscany, Italy (1998)

Nine cases of skin and nail infection due to Fusarium oxysporum, diagnosed in Tuscany in the period 1985-97, are described. Two manifested as interdigital intertrigo of the feet and seven as onychomycosis. All were diagnosed on the basis of repeated mycological examination, direct microscope observation and culture, as well as histological examination of biopsy specimens in two cases of intertrigo. Fragments of the fungal colonies were examined by scanning electron microscopy (SEM) for more detailed observation of fungal morphology. All patients had normal immune status and a history of the infection extending several years. Four of the patients with onychomycosis were treated with oral itraconazole, and clinical and mycological recovery was achieved in three cases. Two others were treated with cyclopyrox nail lacquer, successfully in one case. One patient with intertrigo was treated with oral itraconazole and one with oral terbinafine; both were also treated and with topical drugs, however clinical recovery was not confirmed by the mycological results.
The First Enantioselective Synthesis of the <i>cis</i>-2-Carboxy-5-phenylpyrrolidine (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTThe First Enantioselective Synthesis of the cis-2-Carboxy-5-phenylpyrrolidineMansour Haddad, Hassan Imogaï, and Marc LarchevêqueView Author Information Laboratoire de Synthèse organique, UMR 7573 du CNRS, ENSCP, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France Cite this: J. Org. Chem. 1998, 63, 16, 5680–5683Publication Date (Web):July 9, 1998Publication History Received2 March 1998Published online9 July 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/jo980396lhttps://doi.org/10.1021/jo980396lbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views640Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Cyclization,Ethers,Pyrrolidines,Rearrangement Get e-Alerts
Analyse des difficultés de mesure de la vitesse de l'air dans les industries agro-alimentaires (1995)

National audience
Counteracting spontaneous transformation via overexpression of rate-limiting DNA base excision repair enzymes (2001)

DNA damage of endogenous origin may significantly contribute to human cancer. A major pathway involved in DNA repair of endogenous damage is DNA base excision repair (BER). BER is rather efficient in human cells but a certain amount of endogenous damage inevitably escapes mending and likely contributes to human carcinogenesis. Apart from some glycosylases that are particularly sluggish (e.g. 8-oxoG DNA glycosylase), recent work suggests that the general rate-limiting steps of BER may be trimming of 2-deoxyribose 5-phosphate in case the process is started by a monofunctional glycosylase or trimming of a 3'-blocking fragment, in case BER is started by a bifunctional glycosylase or in the case of single-strand breaks produced by free radical attack. Overexpression of the 5'-deoxyribophosphodiesterase (dRPase) domain of DNA polymerase beta, on the one hand, and of yeast APN1 protein, containing an efficient 3' repair activity, on the other, may lead to improved BER in mammals. The recently characterized S3 protein of Drosophila, containing both dRPase and 3'-trimming activities, could also be considered for overexpression studies. The possible protecting role of enhanced BER could be investigated in cultured rodent embryonic fibroblasts undergoing spontaneous transformation, a most interesting system that merits rediscovery.
Higher Order Parametric X-Rays (1991)

Parametric x-radiation (PXR) may be described as the Bragg scattering of virtual photons to produce real x-rays which satisfy the Bragg condition dsin = n, where is the angle between the electron beam direction and a crystal axis. Enhanced higher order parametric x-radiation from the 10021 plane of a mosaic graphite crystal has been observed. Production of PXR of the order n=2 exceed that from the first order, and x-rays of order up to n=6 are readily seen. The production of higher order x-radiation is obtained by using a thick crystal where the formation and attenuation lengths are exploited to enhance higher energy x-ray formation relative to the lower energy first order x-radiation. Photons of energy 5 to 30 KeV have been measured. The experiment was conducted with a 90 MeV electron beam from the Naval Postgraduate School electron linear accelerator. A three axis target position program, Easy-Mover, was developed to allow for precision orientation of the crystal axis with respect to the electron beam.
Exploratory Analysis of Public Transportation Data in Curitiba (2016)

Smart transportation systems have been providing more data over time (such as bus routes, users, smartphones, etc.). Such data provides a number of opportunities to identify various facets of user behavior and traffic trends. In this paper we address some of the urban mobility challenges (already discussed by the Brazilian Computer Society), from a number of different perspectives, including (i) pattern discovery, (ii) statistical analysis, (iii) data integration, and (iv) open and connected data. In particular, we present an exploratory data analysis with GIS for public transportation toward a case study in Curitiba, Brazil.
Quantification of Human High-Molecular-Weight Kininogen (HMW-KGN) by Specific Hemagglutination Inhibition Reaction (1977)

HMW-KGN bears antigenic determinants shared by LMW-KGN, but also has antigenic properties unique to HMW-KGN. An antiserum which reacted only with HMW-KGN was prepared by exhaustive adsorption of antiserum to both HMW-KGN and LMW-KGN with a preparation of LMW-KGN. Using such an antiserum, HMW-KGN can be quantified by a hemagglutination inhibition assay.
300 ampere, 1000 volt hermetic Darlington transistor (2003)

A hermetic package designed for high performance in hostile environments and military applications has been developed to replace the plastic, nonhermetic, industry-standard 300 A KS62 Darlington transistor. the hermetic package uses a flat copper bus for the collector and emitter terminals, which are isolated from the metal package with oblong ceramic insulators. The collector and emitter terminals are terminated on the top of the hermetic package and are isolated from the package body with a plastic cover. The hermetic package with this plastic cover has the same footprint and dimensions as, and is interchangeable with, the 300 A plastic Darlington transistor. The designer therefore has a choice of selecting either the hermetic or nonhermetic package at any time during design or even changing to the hermetic package during production or as a field retrofit. Another unique feature is the use of a relatively heavy 0.030 inch thick lid that is TIG- (tungsten-inert-gas-) welded to complete the hermetic sealing of the package body. The hermetic package is desirable for high-current Darlington transistors and MOSFETs or other high-current semiconductors used in military and other hostile ambient applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Comparison of Excretion of Nicotinuric Acid After Ingestion of Two Controlled Release Nicotinic Acid Preparations in Man (1988)

We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten subjects following 500 mg oral ingestion of each product. Nicotinuric acid is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid. Although both products demonstrated controlled release profiles, the rate of appearance of nicotinic and nicotinuric acid in the urine as well as the rate of in vitro drug dissolution of the Bronson product were more rapid compared with Nicobid. Moreover, the total amounts of nicotinic acid and nicotinuric acid recovered in the urine after 24 hours were greater for the Bronson product (P less than .05). Since sustained presentation of nicotinic acid to the liver may correlate with clinical antihyperlipidemic effects, our results suggest that the Bronson product may prove to be a clinically useful preparation.
Toward a New Type of Anhydrous Organic Proton Conductor Based on Immobilized Imidazole (2003)

Extensive studies on a model system (imidazole-terminated ethylene oxide oligomers doped with small amounts of strong acids) for a proton-conducting polymer functioning without a liquid phase, but instead using imidazole tethered to the backbone via flexible spacers as a proton solvent, are presented and the parameters governing conductivity and its mechanism are discussed. Temperature-dependent conductivities are well described by free-volume considerations (VTF-behavior). Thus, besides a high density of imidazole moieties, a low Tg is in favor of high proton conductivity, which experimentally is shown to be predominantly due to structure diffusion. The available free volume is suggested to correlate with the rate of hydrogen bond breaking and forming processes within the dynamical hydrogen bond networks, which generally limit the rate of long-range diffusion of protonic defects via structure diffusion. The equilibrium constants for the protonation of imidazole by two different dopants in an oligo(ethylene oxide) environment are determined by NMR, indicating complete dissociation of strong acids such as trifluoroacetic acid. The crystal structure obtained from one of the model compounds is dominated by hydrogen bond interactions interconnecting the imidazole units and suggesting an easy proton migration within the imidazole-rich domains.
SERMs: Evolutionary Chemistry, Revolutionary Biology (2002)

Estrogens are known as important modulators of development, growth and maintenance of primary sexual physiology. The medical field has also grown increasingly appreciative of the effects of estrogens on non-traditional target tissues such as bone, cardiovascular tissue and the CNS. Postmenopausal women have been the beneficiaries of estrogen supplementation regimes, but the proliferative actions of estrogens on uterine and breast tissue have raised concerns. Combining estrogens with progestins (HRT) has succeeded in blunting the uterine effects of estrogen but not the effects of estrogens on breast tissue, and breakthrough bleeding induced by HRT regimes continues to present compliance issues. The discovery by Jordan and coworkers in 1987 that the "antiestrogens" tamoxifen and raloxifene showed estrogenic effects in preventing bone loss in ovariectomized rats revolutionized the way we have come to the think of nuclear receptor functioning. Since that time, broad insights have been garnered into both the mechanisms involved in the primary, ligand activated nuclear transcription pathway as well as other, non-traditional pathways via which estrogens may exert their effects. The recent discovery of a second estrogen receptor ERbeta has provided additional possibilities for investigation and therapeutic intervention. Even though raloxifene (Evista) has been approved for the treatment and prevention of osteoporosis in postmenopausal women, there is room for improvement. For example, normal HRT alleviates hot flush and urogenital complaints; raloxifene does neither. In addition raloxifene does not raise overall HDL (while HRT does) but does increase venous thromboembolisms. The ideal SERM will maximize all of the positive estrogen attributes while minimizing the negatives, and to that end, there has been considerable activity in the medicinal chemistry community dedicated towards the modification of the SERM structure to achieve compounds with preferable profiles. What we have witnessed, so far, is an evolutionary march of compounds with potential clinical benefit over raloxifene, although the ideal SERM remains to be realized.
An apparatus for degassing liquids by vacuum sublimation (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn apparatus for degassing liquids by vacuum sublimationThomas Norman Bell, Edward L. Cussler Jr., Kenneth R. Harris, C. N. Pepela, and Peter J. DunlopCite this: J. Phys. Chem. 1968, 72, 13, 4693–4695Publication Date (Print):December 1, 1968Publication History Published online1 May 2002Published inissue 1 December 1968https://pubs.acs.org/doi/10.1021/j100859a059https://doi.org/10.1021/j100859a059research-articleACS PublicationsRequest reuse permissionsArticle Views250Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Networked information resource discovery: an overview of current issues (1995)

Users need a new class of information retrieval systems to help them utilize effectively the increasingly vast selection of networked information resources becoming available on the Internet. These systems-usually called network information discovery and retrieval (NIDR) systems-must operate in a highly demanding, very large-scale distributed environment that encompasses huge numbers of autonomously managed and extremely heterogeneous resources. The design of successful NIDR systems demands a synthesis of technologies and practices from computer science, computer-communications networking, information science, librarianship, and information management. This paper discusses the range of potential functional requirements for information resource discovery and selection, issues involved in describing and classifying network resources to support discovery and selection processes, and architectural frameworks for collecting and managing the information bases involved. It also includes a survey and analysis of selected operational prototypes and production systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Resolution of chromosomes III and VI of Aspergillus nidulans by pulsed-field gel electrophoresis shows that the penicillin biosynthetic pathway genes pcbAB, pcbC, and penDE are clustered on chromosome VI (3.0 megabases) (1992)

An improved electrophoretic molecular karyotype of Aspergillus nidulans ATCC 28901 has been obtained by contour-clamped electric field gel electrophoresis, which separates seven chromosomal bands and allows resolution of chromosomes III and VI. The three genes of the penicillin biosynthetic pathway, pcbAB, pcbC, and penDE, encoding alpha-aminoadipyl-cysteinyl-valine synthetase, isopenicillin N synthase, and isopenicillin N acyltransferase, respectively, are clustered together on a chromosome of 3.0 Mg, corresponding to linkage group VI, whereas the argB gene was located on a chromosome of 3.4 Mb, corresponding to linkage group III. Three other strains of A. nidulans contained a modified chromosome III of about 3.1 Mb that overlaps with chromosome VI, forming a doublet. Resolution of chromosomes III and VI in strain ATCC 28901 allowed unequivocal mapping of the penicillin gene cluster on chromosome VI of A. nidulans.