gebhart/patrepeval huggingface dataset:
Your Research Results Look Compelling, but Are They Reliable? (2014)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTYour Research Results Look Compelling, but Are They Reliable?Jillian M. BuriakCite this: Chem. Mater. 2014, 26, 7, 2211–2213Publication Date (Web):April 8, 2014Publication History Published online8 April 2014Published inissue 8 April 2014https://pubs.acs.org/doi/10.1021/cm5010449https://doi.org/10.1021/cm5010449editorialACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views9819Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (5 MB) Get e-AlertscloseSUBJECTS:Catalysts,Computational chemistry,Materials,Mathematical methods,Nanoparticles Get e-Alerts
Indenone synthesis. Improved synthetic protocol and effect of substitution on the intramolecular Friedel–Crafts acylation (1994)

An improved protocol for the construction of substituted indenones is presented. Also the effect of substitution on the intramolecular Friedel–Crafts acylation was noted. Specifically, if there is no substitution at the 2-position of the indenone poor yields of cyclized material were obtained, if at all, while the substitution of a methyl or ethyl group greatly improved the yield of cyclized material. Placement of a large group (e.g., benzyl) resulted in a diminuation of the improved yield. The new synthetic procedure could, in principle, allow for the construction of 2,3-disubstituted indenones. One example of this reaction mode was presented.
Ferrioxalate actinometry. A warning on its correct use (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFerrioxalate actinometry. A warning on its correct useW. D. Bowman and J. N. DemasCite this: J. Phys. Chem. 1976, 80, 21, 2434–2435Publication Date (Print):October 1, 1976Publication History Published online1 May 2002Published inissue 1 October 1976https://pubs.acs.org/doi/10.1021/j100562a025https://doi.org/10.1021/j100562a025research-articleACS PublicationsRequest reuse permissionsArticle Views1029Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Proerectile Pharmacological Effects of Tribulus terrestris Extract on the Rabbit Corpus Cavernosum (2000)

The relaxant responses to acetylcholine, nitroglycerin and EFS by more than 10%, 24% and 10% respectively compared to their control values and the lack of such effect on the contractile response to noradrenaline and histamine indicate that PTN has a proerectile activity. The enhanced relaxant effect observed is probably due to increase in the release of nitric oxide from the endothelium and nitrergic nerve endings, which may account for its claims as an aphrodisiac. However, further study is needed to clarify the precise mechanism of its action.
Photopolymers for holographic recording. IV. New self-processing formulations based on beta -hydroxyethyloxazolidone acrylate (1993)

The use of a highly viscous pentacrylate known to efficiently generate a tridimensional network under photochemical activation in association with a low viscosity oxazolidone acrylate leads to a very promising recording medium. After prepolymerization under homogeneous deep UV exposure this material becomes able to record holographic images without subsequent treatment. Several reactive sensitizers allow its spectral range of sensitivity to extend over the visible and near infrared up to 850 nm. No more than 30 mJ cm-2 are required to record a permanent hologram at 514 nm.
Functional AR Signaling Is Evident in an In Vitro Mouse Follicle Culture Bioassay That Encompasses Most Stages of Folliculogenesis1 (2008)

Androgens have distinct physiological functions within the ovary. The biological action of androgens is primarily exerted through transcriptional regulation by the nuclear androgen receptor (AR), but the molecular cascades governed by AR remain largely unknown. At present, there is imminent concern that environmental man-made chemicals with antiandrogenic properties, among others, are capable of modulating hormonal responses, thereby interfering with normal physiological processes that are critical to fertility. In the present study, we aimed to further characterize a standardized and reproducible follicle culture system in terms of AR expression during in vitro folliculogenesis to be able to use it as a bioassay to study effects of antiandrogens on follicular and oocyte growth, steroid secretion profile, and oocyte meiotic maturation capacity. Immunohistochemical analysis revealed that cytoplasmic AR protein was translocated to the nucleus of granulosa and theca cells in response to endogenous androgen production in theca cells during preantral follicular development. During the antral phase in vitro, AR was differentially expressed in mural and cumulus cells, implying an oocyte-mediated regulation. Treatment of follicles with hydroxyflutamide or bicalutamide, two model antiandrogenic compounds, resulted in reduced follicular growth during the preantral phase, altered steroidogenic environment, and arrest in oocyte meiotic maturation in response to human chorionic gonadotropin. Androgen receptor expression in the culture model corresponded well to what is described in vivo, and this system revealed several ovarian functions targeted by AR antagonists that can be further investigated using more in-depth molecular techniques.
Oral beta 2-selective adrenergic bronchodilators. (1986)

Oral beta 2-agonists (carbuterol, pirbuterol, procaterol, bitolterol, clenbuterol) are drugs widely used as bronchodilators. The efficacy and selectivity of bronchodilators drugs depend on their intrinsic pharmacological properties and on the route of administration. The characteristics of the oral route are easy usage, precise dosage and assured effects. Consequently, disadvantages (delayed onset of action, more frequent side-effects) and the indications, (patients with severe chronic airways obstruction, nocturnal asthmatic attacks, and children and elderly subjects) are clearly evident. The most recent beta 2-agonists have an efficient and prolonged bronchodilating action with well-known side-effects. In order to control drug efficiency in a large population and identify type and degree of adverse reactions, a post-marketing surveillance study was programmed for clenbuterol. The results available confirms that long-term treatment with oral clenbuterol is an effective and safe therapeutical approach. During long-term treatment, tachyphylaxis (a diminished responsiveness) develops. This complex biological phenomenon can be studied, in several ways i.e. functional response of target-organ, appropriate biochemical-metabolical indices, and functional evaluation of the cellular beta-receptors in vitro. Also in the light of evaluation of serum levels of cyclic nucleotides (cyclic adenosine and guanosine monophosphates) it appears that the clinical importance of tachyphylaxis is mild and that chronic therapy with beta 2-agonists is safe and effective when used in selected patients.
Using Geo-location method for lost node in location based services (2015)

The “geo-location” or “location-based services” is an authentication driven system that gives a strong layer in field of lost node localization and that limits the access of information content to specified locations or times with respective to lost node. Yet, the difficulty arises with the GPS related services makes it impractical to incorporate GPS in all the mobile nodes (MN) and subject to availability of GPS signals. The physical location of a particular user or network node at any instant in time is uniquely characterized by a location signature with trace its exact location. These location signature obtain from location node, where several analyst have described how the use of location information can make approach more secured. According to our empirical study the approach can meet the confidentiality, substantiate, clarity, accessibility and practicability of localization of lost node issues in Geo-location authentication systems.
MicroRNA-145 Targeted Therapy Reduces Atherosclerosis (2012)

VSMC-specific overexpression of microRNA-145 is a novel in vivo therapeutic target to limit atherosclerotic plaque morphology and cellular composition, shifting the balance toward plaque stability vs plaque rupture.
Local anesthesia for transrectal ultrasound-guided biopsy of the prostate: A meta-analysis (2017)

A meta-analysis was performed to evaluate the efficacy of local anesthesia in alleviating pain during prostate biopsy. We searched relevant articles in PubMed and Embase. The included studies should be randomized controlled trials (RCT) using local anesthesia to alleviate pain during biopsy, which was recorded by a pain scale. Analgesic efficacy of different local anesthesia techniques were analyzed, including intrarectal local anesthesia (IRLA), periprostatic nerve block (PNB), pelvic plexus block (PPB) and intraprostatic local anesthesia (IPLA). We included 46 RCTs. PNB significantly reduced pain score compared with placebo (-1.27 [95% confidence interval [95% CI] -1.72, -0.82]) or no injection (-1.01 [95% CI -1.2, -0.82]). IRLA with prilocaine-lidocaine cream could also reduced pain (-0.45 [95% CI -0.76, -0.15]), while the IRLA with lidocaine gel was not effective (-0.1 [95% CI -0.24, 0.04]). PNB lateral to the neurovascular bundle had better analgesic effect than at prostate apex (P = 0.02). Combination use of PPB and IRLA considerably alleviated pain of patients compared with the combination of PNB and IRLA (-1.32 [95% CI -1.59, -1.06]). In conclusion, local anesthesia could alleviate patients' pain during the prostate biopsy. PNB was not so effective as PPB.
Optimized Preparation of the Dopaminergic Receptor Ligands 123I-Epidepride and 123I-CIT (1995)

Unlabeled EPI was synthesized in 6 steps from o-vanillin and the required pyrrolidine derivative while cold CIT was prepared from its tartrate salt. EPI and CIT were transformed into the labeling precursors Bu3Sn-EPI and Bu3Sn-CIT which were purified by chromatography on silica gel and analyzed by HPLC. 123I-EPI and 123I-CIT were prepared from the precursors by oxidative iododestannylation (CAT, pH2, RT, 3 min), isolated and purified directly from the reaction mixture by RP-HPLC. Yield and specific activity was 84±6 % (n=11) and ~0.1 nmol/mCi for 123I-EPI, and 86±4 % (n=11) and ~0.5 nmol/mCi for 123I-CIT. Radiochemical purity was >97 % and remained stable through >24 hours. Both ligands demonstrated striatal binding in rats and are being used for clinical studies.
Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors (2008)

QPT-1 was discovered in a compound library by high-throughput screening and triage for substances with whole-cell antibacterial activity. This totally synthetic compound is an unusual barbituric acid derivative whose activity resides in the (-)-enantiomer. QPT-1 had activity against a broad spectrum of pathogenic, antibiotic-resistant bacteria, was nontoxic to eukaryotic cells, and showed oral efficacy in a murine infection model, all before any medicinal chemistry optimization. Biochemical and genetic characterization showed that the QPT-1 targets the beta subunit of bacterial type II topoisomerases via a mechanism of inhibition distinct from the mechanisms of fluoroquinolones and novobiocin. Given these attributes, this compound represents a promising new class of antibacterial agents. The success of this reverse genomics effort demonstrates the utility of exploring strategies that are alternatives to target-based screens in antibacterial drug discovery.
Direct determination of carbonate reservoir porosity and pressure from AVO inversion (1990)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1990Direct determination of carbonate reservoir porosity and pressure from AVO inversionAuthors: John D. PigottRajendra K. ShresthaRichard A. WarwickJohn D. PigottUniversity of Oklahoma, Rajendra K. ShresthaUniversity of Oklahoma, and Richard A. WarwickOryx Energy Co.https://doi.org/10.1190/1.1890047 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1890047FiguresReferencesRelatedDetailsCited byQuantitative Analysis of Geopressure for Geoscientists and Engineers10 February 2021 | , Vol. 74Addressing artifacts in PP-PS registration prior to performing joint impedance inversionSatinder Chopra and Ritesh Kumar Sharma3 January 2020 | The Leading Edge, Vol. 39, No. 1 SEG Technical Program Expanded Abstracts 1990ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1990 Pages: 1779 publication data© 1990 Copyright © 1990 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION John D. Pigott, Rajendra K. Shrestha, and Richard A. Warwick, (1990), "Direct determination of carbonate reservoir porosity and pressure from AVO inversion," SEG Technical Program Expanded Abstracts : 1533-1536. https://doi.org/10.1190/1.1890047 Plain-Language Summary PDF DownloadLoading ...
Home energy management leveraging open IoT protocol stack (2015)

The demand for energy is ever increasing thanks to population growth and industrial development. Efficient energy management at home will be possible provided there is an increased awareness among consumers on their consumption patterns and effective use of their appliances. In India, utility companies continue to gather much of the energy utilization data manually and the automation in home energy metering is yet to be achieved as the smart meter adoption is still in its early stages. While addressing automation in home energy management, it is important to consider solutions that meet country-specific needs like energy costs, fair billing, electricity thefts, system scalability and reliability. In this paper, we present a prototype implementation for home energy management and control, leveraging Internet of Things protocol stack comprising emerging IETF standards such as 6Lo WPAN, RPL and CoAP. The open standards based approach enables seamless integration of the appliances at home to the existing internet infrastructure making remote monitoring, control and data collection over the web possible. Further, enabling IPv6 connectivity to the energy meter leads to better integration of the Data Management Systems of utilities unlike some of the existing proprietary solutions. In our IoT based and IPv6 network connected system, we have a PV panel to generate electricity for DC appliances apart from the main 230V AC supply. Considering the fact that energy supply from renewable sources is intermittent, we provide users with an option of choosing either of the energy sources over the internet. Wireless node based on CC2538 System-on-Chip is interfaced with an energy meter connected to the main AC supply, providing 2 way communications between the utility and the consumer over the internet. The sensor nodes are also used to measure the power consumed by the DC appliances and remote actuation control. Further, a timing based approach is provided for consumers to "turn on" appliances at preset time periods. All the data collected by the sensor nodes are communicated in real time over the internet to the utility and consumer via a border router.
Enhancement of vision systems based on runway detection by image processing techniques (2012)

An explicit way of facilitating approach and landing operations of fixed-wing aircraft in degraded visual environments is presenting a coherent image of the designated runway via vision systems and hence increasing the situational awareness of the flight crew. Combined vision systems, in general, aim to provide a clear view of the aircraft exterior to the pilots using information from databases and imaging sensors. This study presents a novel method that consists of image-processing and tracking algorithms, which utilize information from navigation systems and databases along with the images from daylight and infrared cameras, for the recognition and tracking of the designated runway through the approach and landing operation. Video data simulating the straight-in approach of an aircraft from an altitude of 5000 ft down to 100 ft is synthetically generated by a COTS tool. A diverse set of atmospheric conditions such as fog and low light levels are simulated in these videos. Detection and false alarm rates are used as the primary performance metrics. The results are presented in a format where the performance metrics are compared against the altitude of the aircraft. Depending on the visual environment and the source of the video, the performance metrics reach up to 98% for DR and down to 5% for FAR.
STUDIES ON PREBIOTIC FOOD ADDITIVE (INULIN) IN INDIAN DIETARY FIBRE SOURCES - GARLIC (ALLIUM SATIVUM), WHEAT (TRITICUM SPP.), OAT (AVENA SATIVA) AND DALIA (BULGUR) (2014)

Objective: In the present investigation inulin has been extracted from dietary fibre rich Indian food stuffs, namely, garlic, wheat, oat and dalia. Inulin in the raw food stuff and in the extract has been assessed qualitatively and quantitatively. Methods: Inulin has been extracted from each food source using a combination of lab-scale chemical processes and unit operations. Qualitative assessment of inulin in different food samples and their extracts has been done using FTIR and TLC and quantitative assessment has been done using high performance liquid chromatography (HPLC) and also through combination of TLC and spectro-photometry. Results: The concentration (on dry weight basis) of inulin in natural prebiotic sources has been determined to be 16.60%, 13.07%, 8.94%, 14.95% for garlic, wheat, oat and dalia respectively. The extraction of inulin from garlic, wheat, oat and dalia was possible up to the extent of 99.46%, 77.94%, 53.31% and 89.15% respectively. Conclusion:  It may be concluded that all the food samples, investigated under the study, may serve as potential sources for extraction of prebiotic inulin. The present extraction procedure may be escalated to commercial scale for the production of inulin particularly from garlic for which the efficiency is as high as 99.46%.
Effect of Phosphate on the Corrosion of Carbon Steel and on the Composition of Corrosion Products in Two-Stage Continuous Cultures of <i>Desulfovibrio desulfuricans</i> (1988)

A field isolate of Desulfovibrio desulfuricans was grown in defined medium in a two-stage continuous culture apparatus with different concentrations of phosphate in the feed medium. The first state (V1) was operated as a conventional chemostat (D = 0.045 h) that was limited in energy source (lactate) or phosphate. The second stage (V2) received effluent from V1 but no additional nutrients, and contained a healthy population of transiently starved or resting cells. An increase in the concentration of phosphate in the medium fed to V1 resulted in increased corrosion rates of carbon steel in both V1 and V2. Despite the more rapid corrosion observed in growing cultures relative to that in resting cultures, corrosion products that were isolated under strictly anaerobic conditions from the two culture modes had similar bulk compositions which varied with the phosphate content of the medium. Crystalline mackinawite (Fe(9)S(8)), vivianite [Fe(3)(PO(4))(2) . 8H(2)O], and goethite [FeO(OH)] were detected in amounts which varied with the culture conditions. Chemical analyses indicated that the S in the corrosion product was almost exclusively in the form of sulfides, while the P was present both as phosphate and as unidentified components, possibly reduced P species. Some differential localization of S and P was observed in intact corrosion products. Cells from lactate-limited, but not from phosphate-limited, cultures contained intracellular granules that were enriched in P and Fe. The results are discussed in terms of several proposed mechanisms of microbiologically influenced corrosion.
Cartas enviadas por los jurados valencianos al reino de Aragón durante el interregno (2000)

This work gathers the letters sent to the kingdom of Aragon by the «Consell» of Valencia during the interregnum (1410-1412). These letters are preserved in the collection «Lletres missives» kept in the Valencian Municipal Archives. The aforementioned correspondence deal with various subjects, such as protests against rights violation, complaints about robberies, advice on protection for Valencian citizens, etc. This work brings together the summary of 29 letters.
Array antennas for DGPS (1998)

Multipath interference limits the speed and accuracy of determining position by 'differential' GPS techniques. A geodetic surveyor, for example, requires multipath interference rejection of about 36+20 log/sub 10/ sin /spl epsi/ dB, where /spl epsi/ is the elevation angle of the satellite being observed. Signal processing in a GPS receiver cannot satisfy this requirement. A receiving antenna is required that can sufficiently reject signals arriving from below the horizon. Available antennas have inadequate rejection, and brute-force methods of improving them, e.g., by enlarging their ground-planes, are impractical. A compact, ground-plane-less, dual-band, GPS antenna with improved multipath rejection has been designed and field-tested. This antenna resembles a vertical post rather than a horizontal platter; within its 0.1-m diameter, 0.4-m tall radome is a vertical array of turnstile elements. In field tests, a three-element array antenna rejected multipath better than a 0.5-m diameter ground-plane antenna by an average of 5 dB. A five-element array antenna appears superior to a 0.9-m diameter ground-plane antenna.
Copper(II)/Tin(II) Reagent for Allylation, Propargylation, Alkylation, and Benzylation of Disulfides and Elemental Sulfur:  New Insight into the “Copper Effect” (2000)

Organic bromides and iodides react with diorganodisulfides in the presence of stannous chloride and catalytic cupric halide, giving rise to corresponding unsymmetrical sulfides. Similar reactions but with elemental sulfur provide trisulfides and tetrasulfides. The reactions proceed by copper thiolate as principal reactive intermediate.