gebhart/patrepeval huggingface dataset:
Biogerontologists' Duty to Discuss Timescales Publicly (2004)

Aging is unpopular with the general public-but, it would seem, only up to a point. Treatments that claim (sometimes justifiably) to extend the total and/or healthy life span of elderly people, or even just make them look younger, are welcomed with open wallets throughout the world. If, however, one suggests to the typical nonbiologist-or even to the typical nongerontologist biologist-that we should therefore aim, in due course, to take this desire to its logical conclusion and bring aging under the same degree of control that we currently have over most infectious diseases, one is nearly always met with strong and sometimes strident opposition. I argue here that the prevalence of this outright irrationality is largely the fault of gerontologists themselves. Most people harbor a deep-seated fear of profound change in their lives and embrace it only after extensive soul-searching to convince themselves of its benefit. It cannot and should not be denied that a postaging world would be as profoundly different from today's as we can imagine. Hence, when given the opportunity to postpone sober consideration of its pros and cons, most people leap at that opportunity. It is provided to them by the nearly universal refusal of gerontologists to speculate about the timescales within which truly effective rejuvenation therapies may be developed. I suggest that this reticence, while appropriate in purely scientific fields, is hugely irresponsible in a biomedical discipline, because of its potential to delay the development of such therapies by denying them the funding that would be forthcoming if society had greater optimism concerning their foreseeability. Arguments that such funding, and/or the public's trust in scientists, would be short-lived if timescale predictions were not borne out are too flimsy to outweigh this. A further danger is the avoidable loss of life following the development of rejuvenation therapies that would result from inadequate ability to provide them universally; here again, scientists today can minimize this loss of life by agitating for forward planning by government, which will only occur when policymakers' minds are concentrating on timescale predictions.
RC active filter design handbook (1985)

Introduction to Active Filters Approximation The Second Order Function Active Components Analysis of Active Filters Sallen and Key Filters Multiple-Loop Feedback Filters Biquads I: The State-Variable Structure Biquads II: The Current Generalized Immittance (CGIC) Structure Design of High-Order Active Filters Practical Limitations of RC-Active Filters Computer Programs Design Aids Index Author Index Subject Index Name Index.
Statistical process control in semiconductor manufacturing (1992)

The author presents a brief survey of standard SPC (statistical process control) schemes, and illustrates them through examples taken from the semiconductor industry. These methods range from contamination control to the monitoring of continuous process parameters. It is noted that, even as SPC is transforming IC production, the peculiarities of semiconductor manufacturing technology are transforming SPC. Therefore, the author describes novel SPC applications which are now emerging in semiconductor production. These methods are being developed to monitor the short production runs that are characteristic of flexible manufacturing. Additional SPC techniques suitable for in situ multivariate sensor readings are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Absolute and relative locations of similar events with application to microearthquakes in southern Iceland (1995)

It is well known that similar earthquakes, i.e. earthquakes having almost identical waveforms, allow extremely accurate relative timing of the seismic arrivals. This has traditionally been used for achieving accurate relative locations of clusters of similar earthquakes. The arrival time differences between similar events depend not only on their relative location but also on the absolute location of the group. Moving a pair of events 200 m while retaining their relative locations can cause a 1 ms change in the time difference between the first arrivals of the events at a station 6 km distant. A change in time difference of 1ms can easily be estimated by cross-correlating the waveforms of the two earthquakes. We use the accurate relative timings to improve absolute locations of groups of similar events, as well as to obtain extremely accurate relative locations. The absolute locations from relative timings are expected to have errors that are independent of the errors associated with locations based on absolute arrival time observations.
The Structure of “Active Formaldehyde” (N<sup>5</sup>, N<sup>10</sup> -Methylene Tetrahydrofolic Acid)<sup>1</sup> (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of "Active Formaldehyde" (N5, N10 -Methylene Tetrahydrofolic Acid)1M. J. Osborn, P. T. Talbert, and F. M. HuennekensCite this: J. Am. Chem. Soc. 1960, 82, 18, 4921–4927Publication Date (Print):September 1, 1960Publication History Published online1 May 2002Published inissue 1 September 1960https://pubs.acs.org/doi/10.1021/ja01503a043https://doi.org/10.1021/ja01503a043research-articleACS PublicationsRequest reuse permissionsArticle Views503Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Resilience of pore‐water chemistry and calcification in photosynthetic zones of calcifying sediments (2009)

Photosynthetically driven calcification was investigated in diatom‐dominated carbonate sediments from Bait Reef, Australia. Laboratory measurements conducted over complete diel cycles, using O 2 , pH, CO 3 2‐ , and Ca 2+ microsensors, confirmed that photosynthesis and respiration drive calcification and calcium release via their respective effects on the local pH. However, the dark situation does not simply mirror the light situation. Profiles showed that calcification and calcium release are not necessarily tightly coupled to the light cycle and that mass transfer phenomena need to be considered in diel chemical dynamics. The magnitude and timing of pH and CO2{ 3 concentration changes did not simply follow the light cycle. The pH in the upper 3 mm of the sediment changed more rapidly upon illumination than upon darkening. Consequently, photosynthetically induced calcification began shortly (within 1 h) after illumination, but the pH remained elevated and calcification continued for ~7 h after darkening. Thus, calcification in marine phototrophic sediments is not limited to light periods, but may continue for extended periods after darkening. This decoupling of light, photosynthesis, and calcification has profound consequences for estimates of daily calcification rates, which have previously been made from measurements assuming close to steady states and 12 : 12 h light : dark calcification and decalcification. In Bait Reef sediments, such an assumption underestimates daily calcification rates by two‐ to threefold.
Spectral Methods in Time for Hyperbolic Equations (1986)

A pseudospectral numerical scheme for solving linear, periodic, hyperbolic problems is described. It has infinite accuracy both in time and in space. The high accuracy in time is achieved without increasing the computational work and memory space which is needed for a regular, one step explicit scheme. The algorithm is shown to be optimal in the sense that among all the explicit algorithms of a certain class it requires the least amount of work to achieve a certain given resolution. The class of algorithms referred to consists of all explicit schemes which may be represented as a polynomial in the spatial operator.
Selective Fluorescence Turn-On and Ratiometric Detection of Organophosphate Using Dual-Emitting Mn-Doped ZnS Nanocrystal Probe (2014)

Semiconductor nanocrystals (NCs) possess unique photoluminescent properties which can be used to design fluorescence probes for chemo/biosensing applications. Several have recently emerged that offer excellent turn-on or ratiometric fluorescence chemosensory protocols by sophisticated procedures, but it has been challenging to realize all of these advantages in a single construct. Herein, we develop an intrinsic dual-emitting Mn-doped ZnS nanocrystal-based probe that achieves this goal with turn-on and ratiometric fluorescence response for the determination of organophosphate (diethylphosphorothioate, DEP). The probe relies on the modification of dopamine dithiocarbamate on the surface of NCs and the modulation of dual emission through a photoinduced electron transfer process, which makes use of red fluorescence of Mn(2+) ions doped in the NCs as specific recognition for the target analyte and blue defect emission of the NCs as stable internal reference. In presence of DEP, the red emission of the probe is thus enhanced by switching off the electron transfer pathway, while the blue emission is almost unchanged. With the addition of different amounts DEP, the two emission intensity ratios gradually vary and display color changes from dark-blue to purple to red. Thus, this method generates turn-on and ratiometric fluorescence signals for quantitative and visual detection of the analyte. Significantly, the dual-emitting probe has been used to fabricate paper-based test strips for visual detection of DEP residues, which validate the method for its rapid, on-site, and visual identification.
Stereoselectivity in the Catalytic Hydrogenation of an Enamine. Selective Formation of Either<i>CIS</i>- or<i>trans</i>- Tertiary Amines (1979)

Abstract Conditions have been found where catalytic hydrogenation of the enamine (II) may produce either the trans-2- (3,4-dichlorophenyl) -3 -NN-dimethylaminomethylbicyclo[2,2,2]octane exclusively, or the cis-isomer with high stereoselectivity.
A wireless fair service algorithm for packet cellular networks (1998)

b order to support diverse communication-intensive redtirne and non red-time data flows over a scarce, varying and shared wireless channel with location-dependent and bursty errors, we defie a service model that has the following charxteristi~short-tern fairness among flows which perceive a clean channel, worst-case delay bounds for packets, short-term throughput bounds for flows with clean channels and Iong-tem throughput bounds for dl flows with bounded channel error, optimal schedulable region, and support for both delay sensitive and error sensitive data flows.
Asymmetric Hydrogenation of Cyclic Ketimines Catalyzed by Iridium(I)-Complexes of BCPM and Its Analog1 (1995)

Modified pyrrolidinebisphosphines, BCPM (1a) and its analog MCCPM (1b), were found to be more efficient ligands than the original BPPM (2a) in the iridium(I)-catalyzed asymmetric hydrogenation of imines in the presence of iodide. In particular, the modified ligands (1a,b) showed very high enantioselectivity of up to 91% ee in the hydrogenation of 2,3,3-trimethylindolenine (6) in the presence of bismuth(III) iodide.
Patent Update Biologicals & Immunologicals: DNA topoisomerase inhibitors: potential uses in molecular medicine (1994)

(1994). Patent Update Biologicals & Immunologicals: DNA topoisomerase inhibitors: potential uses in molecular medicine. Expert Opinion on Therapeutic Patents: Vol. 4, No. 6, pp. 655-668.
DESIGN ALTERNATIVES FOR A COOPERATIVE GARBAGE COLLECTOR FOR THE C++ PROGRAMMING LANGUAGE (1991)

Currently, conservative garbage collectors for C++ are the collectors which enjoy the most use. While prototype cooperative collectors have been written for C++, the language does not support either a type-safe or a reliable cooperative collector. This report examines design alternatives for adding support to the C++ programming language for cooperative garbage collection and discusses in detail alternatives which provide language support for user defined cooperative collectors. This report concludes that no C++ collector supporting multiple storage classes can be completely cooperative. Furthermore, language-recognized parameterized smart pointer types show promise both for supporting user defined collectors and for supporting persistent object caches, distributed object stores and other kinds of storage managers. Further research is needed however, in the areas of type inquiry and the coordination of multiple storage managers, before any parameterized smart pointer proposal can be completed. This discussion is based on experiments with a compacting, cooperative collector in existing implementations of C++. The changes to the language discussed in this report have not yet been implemented.
THE LAST HURRAH (2004)

SUBTITLE: AN ORGANISATION REPRESENTING LINER OPERATORS HAS FINALLY BITTENTHE BULLET AND PRODUCED PROPOSALS THAT COULD MEAN THE END OF LINER CONFERENCES AS WE HAVE COME TO KNOW THEM. TIM POWER EXAMINES THE NEW INITIATIVE AND WHAT ITS IMPACT COULD BE.
Electrically-doped CVD-graphene transparent electrodes: application in 365 nm light-emitting diodes (2019)

A highly transparent conductive electrically-doped CVD-graphene electrode and its application in 365 nm light-emitting diodes.
Highly Efficient Visible‐Light Plasmonic Photocatalyst Ag@AgBr (2009)

Visible improvements: Owing to the plasmon resonance of silver nanoparticles deposited on the surface of AgBr, the newly-prepared plasmonic photocatalyst Ag section signAgBr has a strong absorption in the visible region (see picture) and shows high efficiency in the photodegradation of organic pollutants under visible light.
Systemic Administration of an Attenuated, Tumor-Targeting<i>Salmonella typhimurium</i>to Dogs with Spontaneous Neoplasia: Phase I Evaluation (2005)

Administration of VNP20009 at doses with acceptable toxicity results in detectable bacterial colonization of tumor tissue and significant antitumor activity in tumor-bearing dogs.
Epithelial Cells and Their Neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells (2005)

Intraepithelial gammadelta-T cells are present in all epithelial tissues, where they reside in close contact with neighboring epithelial cells. Our data support the idea that the role of these cells is to monitor neighboring cells for signs of damage or disease. Once a problem is detected, the intraepithelial gammadelta-T cells can lyse damaged or malignant epithelial cells, directly participate in tissue repair through production of epithelial growth factors, and play a unique role in the recruitment of inflammatory cells to the site of damage. Intraepithelial gammadelta-T cells play unique roles in homeostasis and disease.
A Perceptually Driven Model for Transmission of Arbitrary 3D Models over Unreliable Networks (2006)

3D transmission over unreliable networks needs to take into account the possibility of packet loss. In this work we describe a perceptually motivated strategy for joint transmission of texture and mesh over unreliable networks. The approach is described initially considering regular mesh structure, to show the utility of optimizing the texture-mesh tradeoff. In order to generalize our approach to arbitrary meshes we consider stripification of the mesh, combined with a strategy that does not need texture or vertex packets to be re-transmitted. Only the valence (connectivity) packets need to be re-transmitted; however, storage of valence information requires only 10% space compared to vertices and even less compared to photo-realistic texture. Thus, only less than 5% of the packets may need to be re-transmitted in the worst case to allow our algorithm to successfully reconstruct an acceptable object under severe packet loss. Results showing the implementation of the proposed approach are described.
Involvement of Bradykinin in Trypsin-Induced Urinary Bladder Contraction in Cyclophosphamide-Treated Rats (2011)

Protease-activated receptor-2 (PAR-2) is activated by serine proteases, such as trypsin and mast cell tryptase. Previous studies have demonstrated that both trypsin and PAR-2 activating peptide contract isolated rat urinary bladder preparations, however, the mechanisms are not fully understood. In the present study, we examined the role of bradykinin in contractions induced by trypsin and the PAR-2 agonist 2-furoyl-LIGRL-NH(2) in urinary bladders isolated from control or cyclophosphamide (CYP)-induced cystitis rats. The contractile effects of trypsin were significantly greater in the preparations obtained from CYP-treated rats than in those from controls. The bradykinin B2 receptor antagonist Hoe 140 did not affect trypsin-induced contractions in control rat bladders, whereas it significantly reduced the contractile effects of trypsin on bladders from CYP-treated rats. On the other hand, Hoe 140 failed to affect contractions induced by the PAR-2 agonist 2-furoyl-LIGRL-NH(2). These results suggest that the actions of trypsin on urinary bladders in cystitis rats are partly exerted through stimulation of bradykinin B2 receptor in a PAR-2-independent manner. This mechanism seems to be involved in the enhancement of trypsin-induced bladder contractions observed after induction of cystitis with CYP in rats.
Evaluation of breast tissue with confocal strip-mosaicking microscopy: a test approach emulating pathology-like examination (2017)

Confocal microscopy is an emerging technology for rapid imaging of freshly excised tissue without the need for frozen- or fixed-section processing. Initial studies have described imaging of breast tissue using fluorescence confocal microscopy with small regions of interest, typically 750 × 750 ?? ? m 2 . We present exploration with a microscope, termed confocal strip-mosaicking microscope (CSM microscope), which images an area of 2 × 2 ?? cm 2 of tissue with cellular-level resolution in 10 min of excision. Using the CSM microscope, we imaged 34 fresh, human, large breast tissue specimens from 18 patients, blindly analyzed by a board-certified pathologist and subsequently correlated with the corresponding standard fixed histopathology. Invasive tumors and benign tissue were clearly identified in CSM strip-mosaic images. Thirty specimens were concordant for image-to-histopathology correlation while four were discordant.
Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8. (1993)

We had previously demonstrated that the herpes simplex virus 1 (HSV-1) single-stranded DNA-binding protein (ICP8) can specifically stimulate the helicase activity of the HSV-1 origin-binding protein (UL9). We show here that this functional stimulation is a manifestation of a tight interaction between UL9 protein and ICP8. By using protein-affinity chromatography, we have demonstrated the specific binding of purified UL9 protein to immobilized ICP8 and vice versa. Furthermore, ICP8 is specifically retained by a column on which the C-terminal 37-kDa DNA-binding domain of the UL9 protein was immobilized. The interaction between ICP8 and the DNA-binding domain of the UL9 protein was confirmed by cochromatography of the two proteins. These results suggest that the UL9 protein and ICP8 form a tight complex that functions in origin recognition and unwinding.
Automated ligand placement and refinement with a combined force field and shape potential (2006)

An automated computational procedure for fitting a ligand into its electron density with the use of the MMFF94 force field and a Gaussian shape description has been developed. It employs a series of adiabatic optimizations of gradually increasing shape potential. Starting from a set of energy-relaxed ligand conformations, the final results are structures realistically strained to fit the crystallographic data.
Basal Chromogranin a and Gastrin Concentrations in Circulation Correlate to Endocrine Cell Proliferation in Type-A Gastritis (1997)

In type-A gastritis, analysis of plasma chromogranin A may be a useful complement to histology in estimating the endocrine cell mass. Moreover, subclinical type-A gastritis may be a source of error when chromogranin A analysis is used in the search for neuroendocrine neoplasia.
Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs (2012)

In dogs, MK 0467 administered concurrently with medetomidine IV or IM reduced the cardiovascular effects of medetomidine but had no detectable effect on sedation scores.
Proposition for the biochemical mechanism occurring in the sucrose isomerase active site (1998)

Sucrose conversion by sucrose isomerase from Protaminobacter rubrum, Serratia plymuthica and Erwinia rhapontici was investigated in the presence of different monosaccharides in the reaction mixture. These conditions led to inhibitory effects and to glucosyl transfer of the glucose moiety of sucrose to the exogen monosaccharide. Comparison of the structure of the different inhibitors and acceptors has allowed us to suppose the binding of the sucrose molecule into the active site, and thereafter, to propose the possible biochemical reactions leading to the formation of different products from sucrose. This study also underlines the close homologies between these enzymes.
Regeneration of protoplasts of Clostridium pasteurianum ATCC 6013 (1983)

A procedure has been developed for the regeneration of Clostridium pasteurianum protoplasts with frequencies of up to 10% reversion being obtained.