gebhart/patrepeval huggingface dataset:
Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease (2013)

The macrophage, a versatile cell type prominently involved in host defense and immunity, assumes a distinct state of alternative activation in the context of polarized type 2 immune responses such as allergic inflammation and helminth infection. This alternatively activated phenotype is induced by the canonical type 2 cytokines interleukin (IL)-4 and IL-13, which mediate expression of several characteristic markers along with a dramatic shift in macrophage metabolic pathways that influence surrounding cells and tissues. We discuss recent advances in the understanding of IL-4- and IL-13-mediated alternatively activated macrophages and type 2 immune responses; such advances have led to an expanded appreciation for functions of these cells beyond immunity, including maintenance of physiologic homeostasis and tissue repair.
Progress in Diesel Engine Emissions Control (1992)

A considerable amount of work was carried out in the mid-1980s to develop heavy-duty diesel engines that could meet limits on particulate emissions. These limits, although high by today’s standards, were considered very restrictive. Some manufacturers struggled to achieve the 0.6 g/bhp-h particulate matter limit with enough margin for production variabilities and to account for the deterioration factor. Significant progress was achieved in diesel emissions control through engine and fuel system design changes. This eventually made it possible to meet a particulate level of 0.25 g/bhp-h for 1991. The next target level for particulate emissions is 0.1 g/bhp-h for the 1994 heavy-duty engine. To meet the challenge, engine developers are not only considering engine and injection system design changes but also fuel improvements and exhaust aftertreatment. This paper includes a review of past and current strategies used to control emissions in the modern diesel engine.
Dual Mode Microwave System to Enhance Early Detection of Cancer (1980)

A dual mode microwave system has been developed that will permit early detection of cancer. The system combines the use of the passive microwave radiometer with an active transmitter. The active transmitter will provide localized heating to enhance early detection by taking advantage of the differential heating (i.e., tumor temperature with respect to surrounding tissue) associated with thermal characteristics of tumors.
A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease (2015)

To discover novel autoantigens associated with Lyme arthritis (LA), we identified T-cell epitopes presented in vivo by human leukocyte antigen (HLA)-DR molecules in patients' inflamed synovial tissue or joint fluid and tested each epitope for autoreactivity. Using this approach, we identified the highly expressed human protein, apolipoprotein B-100 (apoB-100), as a target of T- and B-cell responses in a subgroup of LA patients. Additionally, the joint fluid of these patients had markedly elevated levels of apoB-100 protein, which may contribute to its autoantigenicity. In patients with antibiotic-refractory LA, the magnitude of apoB-100 antibody responses correlated with increased numbers of plasma cells in synovial tissue, greater numbers and activation of endothelial cells, and more synovial fibroblast proliferation. Thus, a subset of LA patients have high levels of apoB-100 in their joints and autoreactive T- and B-cell responses to the protein, which likely contributes to pathogenic autoimmunity in patients with antibiotic-refractory LA.
Solubility of Oxygen in Rubber and in Its Effect on Rate of Oxidation (1930)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Oxygen in Rubber and in Its Effect on Rate of OxidationIra Williams and Arthur M. NealCite this: Ind. Eng. Chem. 1930, 22, 8, 874–878Publication Date (Print):August 1, 1930Publication History Published online1 May 2002Published inissue 1 August 1930https://pubs.acs.org/doi/10.1021/ie50248a019https://doi.org/10.1021/ie50248a019research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Accuracy and Safety of Bedside External Ventricular Drain Placement at Two Different Cranial Sites : Kocher's Point versus Forehead (2011)

Accurate and safe ventriculostomies were achieved using both cranial sites, Kocher's point and the forehead. However, the forehead ventriculostomies provided more accurate ventricular punctures.
Comparison of Serological Markers of Inflammatory Bowel Disease with Clinical Diagnosis in Children (2004)

In our experience, the specificity of IBD Diagnostic System is better than the sensitivity; the sensitivity is better for ulcerative colitis than Crohn's disease (69.2% vs 54.1%). The low sensitivity, especially for Crohn's disease, precludes the possibility that the IBD Diagnostic System can replace traditional studies when evaluating for inflammatory bowel disease. Though we do not exclude inflammatory bowel disease solely by IBD Diagnostic System results, it is reassuring to note that all patients without clinical evidence of inflammatory bowel disease also had negative IBD Diagnostic System results.
Effect of drought stress on yield, proline and chlorophyll contents in three chickpea cultivars (2010)

Drought stress is one of the major abiotic stresses in agriculture worldwide. This study was carried out to investigate the effect of drought stress on proline content, chlorophyll content, photosynthesis and transpiration, stomatal conductance and yield characteristics in three varieties of chickpea (drought tolerant Bivaniej and ILC482 and drought sensitive Pirouz). A field experiment with four irrigation regimes was carried out in a randomized complete block design with three replications. Treatments included control (no drought), drought stress imposed during the vegetative phase, drought stress imposed during anthesis and drought stress during the vegetative phase and during anthesis. All physiological parameters were affected by drought stress. Drought stress imposed during vegetative growth or anthesis significantly decreased chlorophyll a, chlorophyll b and total chlorophyll content. Proline accumulation was higher in ‘ILC482 ’ than in ‘Pirouz ’ both under control and drought stress conditions. Photosynthesis, transpiration, stomatal conductance and yield were higher but sub-stomatal CO2 concentration was lower under drought stress conditions than under control conditions. The results showed that mesophyll resistance is the basic determinate of rate of phototosynthesis under drought stress conditions. Under drought conditions the drought tolerant variety ‘Bivaniej ’ gave the highest yield whereas the drought sensitive variety ‘Pirouz ’ gave the lowest yield. Drought stress at anthesis phase reduced seed yield more severe than that on vegetative stage.
Genetic Transformation of <i>Drosophila</i> with Transposable Element Vectors (1982)

Exogenous DNA sequences were introduced into the Drosophila germ line. A rosy transposon (ry1), constructed by inserting a chromosomal DNA fragment containing the wild-type rosy gene into a P transposable element, transformed germ line cells in 20 to 50 percent of the injected rosy mutant embryos. Transformants contained one or two copies of chromosomally integrated, intact ry1 that were stably inherited in subsequent generations. These transformed flies had wild-type eye color indicating that the visible genetic defect in the host strain could be fully and permanently corrected by the transferred gene. To demonstrate the generality of this approach, a DNA segment that does not confer a recognizable phenotype on recipients was also transferred into germ line chromosomes.
Tumor-inhibiting potential of ZK 112.993, a new progesterone antagonist, in hormone-sensitive, experimental rodent and human mammary tumors. (1990)

The progesterone antagonists Onapristone (ZK 98.299) and Mifepristone (RU 486) proved to be strong inhibitors of various rodent mammary tumors. Therefore, a further potent antiprogestin, ZK 112.993, and 11 beta-(4-acetyl-phenyl)-analog of Mifepristone, with a high progesterone receptor affinity was tested in experimental rodent and human breast cancer models. In the hormone-dependent MXT(+) mammary tumor of the mouse, treatment of tumors immediately after implantation with 5 mg/kg for 6 weeks led to an inhibition of growth by 95%, being significantly superior to that caused by tamoxifen, diethylstilbestrol and Onapristone. Treatment of established MXT(+) tumors by ZK 112.993 at doses of 0.5, 1.0 and 2.0 mg/kg led to a strong inhibition that equalled that of ovariectomy and surpassed that of Onapristone in the lower doses. In the human, receptor positive mammary carcinoma T61 implanted in male, castrated nude mice, ZK 112.993 (10 mg/kg) significantly retarded tumor growth. Its effect was again superior to Onapristone though weaker than that of tamoxifen. The NMU-induced mammary carcinoma of the rat (established tumors) was inhibited by ZK 112.993 (5 and 10 mg/kg) in a dose-dependent manner slightly superior to Onapristone but weaker than after ovariectomy. Due to its strong antitumor activity and because of the innovative mechanism of action of antiprogesterones in tumor treatment, ZK 112.993 could be of great value for the treatment of breast cancer.
An Overview of the Mechanisms of Action of Herbicide Safeners (1991)

Abstract Herbicide safeners are chemicals used for manipulating the tolerance of large-seeded grass crops to selected soil-applied herbicides. The physiological interactions of herbicides and their respective safeners are characterized by the following facts: a) safeners are most effective when applied prior to or simultaneously with the herbicides whose injury they prevent; b) safeners exhibit a high degree of botanical and chemical specificity protecting only certain grasses against injury caused from specific classes of herbicides; and c) protected grass crops are moderately tolerant to the antagonized herbicides. At the biochemical level, safeners may act either as “bioregulators” regulating the amount of a given herbicide that reaches its target site in an active form or as “antagonists” of herbicidal effects at a similar site of action. A safener-induced enhancement of herbicide detoxication in protected plants is currently viewed as the most apparent mechanism for the action of the currently available safeners. Safeners enhance the conjugation of carbamothioate and chloroacetanilide herbicides with glutathione either by elevating the levels of reduced glutathione (GSH) or by inducing the activity of specific glutathione S̱-transferases (GSTs). A safener-induced enhancement of the activity of other degradative enzymes such as the cytochrome P450-dependent mixed function oxidases or UDP-glucosyl transferases seems to be important for the protective action of safeners against injury from aryloxyphenoxypropionate, imidazolinone, and sulfonylurea herbicides. Metabolic processes related to acetyl-CoA metabolism have been implicated as likely target sites for a competitive antagonism between safeners and chloroacetanilide or carbamothioate herbicides. At the molecular level, the “gene activation” and “gene amplification” theories offer a likely explanation for the action of safeners.
Stevensine, a novel alkaloid of an unidentified marine sponge (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStevensine, a novel alkaloid of an unidentified marine spongeKim F. Albizati and D. John FaulknerCite this: J. Org. Chem. 1985, 50, 21, 4163–4164Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://doi.org/10.1021/jo00221a041Request reuse permissionsArticle Views375Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (272 KB) Get e-Alertsclose Get e-Alerts
Surface Modification of Nanosilica for PP Composites (2012)

Due to its high purity, favourable surface chemistry and huge specific surface area, fumed silica nanoparticlesare suitable inorganic nanoscopic templates for organic modification and nanocomposite studies. Polypropylene offers good properties with low or moderate cost for many technical applications, such as for solid dielectrics. Polypropylene and hydrophilic silica nanoparticles have inherently dissimilar surface chemistries and organic modification of the silica is usually needed to achieve good mixing and nanocomposite properties. Thetarget is to study robust grafting methods which can be up-scalable without complicated process steps. In thiswork nanosilica particleshave been modified by grafting to method using equimolar amounts of various chain lengths of vinyl functional polyisobutene (PIB) oligomers (molecular weights 320 g/mol, 920 g/mol and 2300 g/mol, determined by material supplier), further functionalized by epoxidation and subsequent reaction with organosilane.The glass transition temperature, viscoelastic properties and crystallization behaviour of the PP compositeswith PIB grafted silicas (4.5 wt% silica) were altered. Especially the PIB2300 grafted silica composite showed improved low temperature fracture toughness, significantly (14°C) lower glass transition measured by DMA and higher crystallization temperature compared to the pure polypropylene.
The well-tempered conversation: interactivity, delay and perceptual VoIP quality (2005)

The factors causing perceptual quality impairment on voice-over-IP (VoIP) connections include traditional network quality-of-service (QoS) parameters like packet loss rate, delay or jitter as well as parameters characterizing the conversation itself. Among the latter ones, we focus on the impact of "conversational interactivity" on the perceptual quality of a phone conversation. We introduce "parametric conversation analysis" as a formal framework for the instrumental investigation of conversational parameters at different transmission delay conditions, we further present the notion of "conversational temperature" as an intuitive scalar metric for the interactivity of conversations, and we demonstrate the application of our methods to a set of conversation recordings performed under various delay conditions, also with respect to results of subjective quality ratings.
Power efficient charge pump in deep submicron standard cmos technology (2003)

A power-efficient charge pump is proposed. The use of low-voltage transistors and of a simple two-phase clocking scheme permits the use of higher operating frequencies compared to conventional solutions, thus obtaining high current, high efficiency, and small area. Measurements show good results for frequencies around 100 MHz. Two test patterns have been fabricated, one with three stages and one with five stages, in a 1.8-V 0.18-μm triple-well standard CMOS digital process (six metals). High-voltage capacitors have been implemented using metal to metal parasitic capacitance.
Design considerations for the transformation of MINIX into a distributed operating system (1988)

MINIX is a version seven UNIX compatible operating system written for the Intel 8088 CPU and IBM-PC circuit package. MINIX is being transformed into a distributed operating system by adding four components to the basic operating system. These include an extended IPC service, network service manager, resource manager, and communication manager. Design considerations include a definition of Distributed Operating Systems (DOSs), a description of existing DOSs, a description of operating system architectural components which add DOS functionality, a plan for the placement of these components within the MINIX environment, an explanation of the types of DOS communication, and the implementation of DOS communication.
Unsupervised co-segmentation through region matching (2012)

Co-segmentation is defined as jointly partitioning multiple images depicting the same or similar object, into foreground and background. Our method consists of a multiple-scale multiple-image generative model, which jointly estimates the foreground and background appearance distributions from several images, in a non-supervised manner. In contrast to other co-segmentation methods, our approach does not require the images to have similar foregrounds and different backgrounds to function properly. Region matching is applied to exploit inter-image information by establishing correspondences between the common objects that appear in the scene. Moreover, computing many-to-many associations of regions allow further applications, like recognition of object parts across images. We report results on iCoseg, a challenging dataset that presents extreme variability in camera viewpoint, illumination and object deformations and poses. We also show that our method is robust against large intra-class variability in the MSRC database.
Effect of Amylose Content on Gelatinization, Retrogradation and Pasting Properties of Flours from Different Cultivars of Thai Rice (2003)

Abstract Presently, rice cultivars are categorized according to amylose content into three groups: low, medium and high amylose content cultivars. The correlation of amylose content with gelatinization properties, retrogradation, and pasting properties of eleven cultivars of Thai rice were investigated. Rice flour was prepared from milled rice by the wet grinding process. Onset ( T o ), peak ( T p ) and conclusion ( T c ) temperatures of gelatinization, (determined by DSC) were found to be highly positively correlated with amylose levels. This correlation could be used for prediction of amylose content of rice flour. Low amylose starch could also be characterized by low degree of retrogradation (%R). The data obtained from RVA‐viscograms (peak viscosity, breakdown, setback, and pasting temperature) can be used only for characterization of the group of low amylose starches (waxy rice). It was demonstrated that low amylose rice starch provided the highest peak viscosity and breakdown and the lowest setback and pasting temperature among the groups investigated.
Variable Selection in Data Mining (2004)

We predict the onset of personal bankruptcy using least squares regression. Although well publicized, only 2,244 bankruptcies occur in our dataset of 2.9 million months of credit-card activity. We use stepwise selection to find predictors of these from a mix of payment history, debt load, demographics, and their interactions. This combination of rare responses and over 67,000 possible predictors leads to a challenging modeling question: How does one separate coincidental from useful predictors? We show that three modifications turn stepwise regression into an effective methodology for predicting bankruptcy. Our version of stepwise regression (1) organizes calculations to accommodate interactions, (2) exploits modern decision theoretic criteria to choose predictors, and (3) conservatively estimates p-values to handle sparse data and a binary response. Omitting any one of these leads to poor performance. A final step in our procedure calibrates regression predictions. With these modifications, stepwise regression predicts bankruptcy as well as, if not better than, recently developed data-mining tools. When sorted, the largest 14,000 resulting predictions hold 1,000 of the 1,800 bankruptcies hidden in a validation sample of 2.3 million observations. If the cost of missing a bankruptcy is 200 times that of a false positive, our predictions incur less than 2/3 of the costs of classification errors produced by the tree-based classifier C4.5.
Extraction of Flow Energy by a Wing Oscillating in Waves (1972)

This paper attempts to investigate the possibility of extracting energy from surrounding flow by a two-dimensional hydrofoil oscillating through a gravity wave in water, or by an airfoil in gust. The greatest possible rate of energy extraction is obtained by the optimum mode of heaving and pitching of the hydrofoil, which is determined by the method of variational calculation of parameters. It is found that energy extraction is impossible if the incident flow is uniform, and becomes feasible only when the primary flow contains a wave component having a transverse velocity distribution normal to both the mean free stream and the wing span. When such waves of sufficiently large amplitude are present, not only flow energy but also a net mechanical power can be extracted from the surrounding flow.
Injectable Hydrogel for Sustained Protein Release by Salt‐Induced Association of Hyaluronic Acid Nanogel (2012)

A hyaluronic acid-based anionic nanogel formed by self-assembly of cholesteryl-group-bearing HA is designed for protein delivery. The HA nanogel spontaneously binds various types of proteins without denaturation, such as recombinant human growth hormone, erythropoietin, exendin-4, and lysozyme. The HA nanogel shows unique colloidal properties, in particular that an injectable hydrogel is formed by salt-induced association of the HA nanogel. A pharmacokinetic study in rats shows that an in situ gel formulation, prepared by simply mixing rhGH and HA nanogel in phosphate buffer, maintains plasma rhGH levels within a narrow range over one week. Therefore, HA nanogels offer a simple method for easy formulation of therapeutic proteins and are effective for sustained protein release systems.
Sustainable Agricultural Model of High Output, Low Input and Less Pollution in Paddy Field (2001)

A model of sustainable agriculture of high output, low input and less pollution (HLL model)in paddy (Oryza L. )fields has been developed. About 10 - 13t/ha of rice and 3 - 4t/ha of fish were harvested by adopting the comprehensive technical system. The amount of chemical fertilizer and pesticide decreased by about 50%, thus greatly controlled the environmental pollution, and simultaneously decreased the methane emission. It was concluded that these comprehensive techniques for this model should be popularized.