gebhart/patrepeval huggingface dataset:
PDC (Programme Delivery Control) (1994)

The automatic control system of the future provides correct recording on home video recorders (VCRs) of transmitted television programmes. PDC consists of two main elements, a preselection function and a recording control function. The programming of the videorecorder uses the transmitted programme listing pages on teletext. The programme that the user wants to tape can be selected with the help of a cursor and read into the VCR with a command on the remote control. The recording of the preselected programme starts automatically, controlled by a unique Programme Identification Label transmitted by teletext together with the television programme when the programme starts. The Programme Identification Label is transmitted during the whole programme to secure correct recording.
Infrared Spectra of Chlorophyll and Related Compounds<sup>1</sup> (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared Spectra of Chlorophyll and Related Compounds1John W. Weigl and Robert LivingstonCite this: J. Am. Chem. Soc. 1953, 75, 9, 2173–2176Publication Date (Print):May 1, 1953Publication History Published online1 May 2002Published inissue 1 May 1953https://pubs.acs.org/doi/10.1021/ja01105a046https://doi.org/10.1021/ja01105a046research-articleACS PublicationsRequest reuse permissionsArticle Views609Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Exergy and Exergoeconomic Model of a Ground-Based CAES Plant for Peak-Load Energy Production (2013)

Compressed Air Energy Storage is recognized as a promising technology for applying energy storage to grids which are more and more challenged by the increasing contribution of renewable such as solar or wind energy. The paper proposes a medium-size ground-based CAES system, based on pressurized vessels and on a multiple-stage arrangement of compression and expansion machinery; the system includes recovery of heat from the intercoolers, and its storage as sensible heat in two separate (hot/cold) water reservoirs, and regenerative reheat of the expansions. The CAES plant parameters were adapted to the requirements of existing equipment (compressors, expanders and heat exchangers). A complete exergy analysis of the plant was performed. Most component cost data were procured from the market, asking specific quotations to the industrial providers. It is thus possible to calculate the final cost of the electricity unit (kWh) produced under peak-load mode, and to identify the relative contribution between the two relevant groups of capital and component inefficiencies costs.
New adjuvants on a polymethylmethacrylate base (1976)

A new type of adjuvant using influenza virus as an antigen is presented. The new adjuvant was produced by polymerizing monomeric methylmethacrylate in the presence of the antigen. As a comparison, influenza virus was added to previously polymerized polymethylmethacrylate particles. In animal experiments, the antibody response in mice and guinea pigs was measured. After polymerization in the presence of the antigen, the adjuvant effect was dependent on the methylmethacrylate concentration used, reaching an optimal concentration at 0.5%. This adjuvant preparation was considerably more effective than simple addition of virus to comparable polymethacrylate preparations or to aluminum hydroxide. The latter two adjuvants were approximately equivalent in effectiveness.
BRCA1 sequence variations in 160 individuals referred to a breast/ovarian family cancer clinic. Institut Curie Breast Cancer Group. (1997)

An account of familial aggregation in breast/ovarian cancer has become possible with the identification of BRCA1 germ-line mutations. We evaluated, for 249 individuals registered with the Institut Curie in Paris, the prior probability that an individual carried a mutation that predisposes to these diseases. We chose 160 women for BRCA1 analysis: 103 with a family history of breast cancer and 57 with a family history of breast-ovarian cancer. To detect small mutations, we generated and analyzed 35 overlapping genomic PCR products that cover the coding portion of the gene, by using denaturing gradient gel electrophoresis. Thirty-eight truncating mutations (32 frameshifts, 4 nonsense mutations, and 2 splice variants) were observed in 15% of women with a family history of breast cancer only and in 40% of those with a history of breast-ovarian cancer. Twelve of 25 distinct truncating mutations identified were novel and unique. Most BRCA1 mutations that had been reported more than five times in the Breast Cancer Information Core were present in our series. One mutation (5149del4) observed in two apparently unrelated families most likely originates from a common ancestor. The position of truncating mutations did not significantly affect the ratio of the risk of breast cancer to that of ovarian cancer. In addition, 15 DNA variants (14 missense mutations and 1 neutral mutation) were identified, 9 of which were novel. Indirect evidence suggests that seven of these mutations are deleterious.
Bio-Inspired Polydopamine: A Versatile and Powerful Platform for Covalent Synthesis of Molecular Sieve Membranes (2013)

Inspired by the bioadhesive ability of the marine mussel, a simple, versatile, and powerful synthesis strategy was developed to prepare highly reproducible and permselective molecular sieve membranes by using polydopamine as a novel covalent linker. Attributing to the formation of strong covalent and noncovalent bonds, ZIF-8 nutrients are attracted and bound to the support surface, thus promoting the ZIF-8 nucleation and the growth of uniform, well intergrown, and phase-pure ZIF-8 molecular sieve membranes. The developed ZIF-8 membranes show high hydrogen selectivity and thermal stability. At 150 °C and 1 bar, the mixture separation factors of H2/CO2, H2/N2, H2/CH4, and H2/C3H8 are 8.9, 16.2, 31.5 and 712.6, with H2 permeances higher than 1.8 × 10(-7) mol·m(-2)·s(-1)·Pa(-1), which is promising for hydrogen separation and purification.
Protein deimmunization via structure‐based design enables efficient epitope deletion at high mutational loads (2015)

Anti-drug immune responses are a unique risk factor for biotherapeutics, and undesired immunogenicity can alter pharmacokinetics, compromise drug efficacy, and in some cases even threaten patient safety. To fully capitalize on the promise of biotherapeutics, more efficient and generally applicable protein deimmunization tools are needed. Mutagenic deletion of a protein's T cell epitopes is one powerful strategy to engineer immunotolerance, but deimmunizing mutations must maintain protein structure and function. Here, EpiSweep, a structure-based protein design and deimmunization algorithm, has been used to produce a panel of seven beta-lactamase drug candidates having 27-47% reductions in predicted epitope content. Despite bearing eight mutations each, all seven engineered enzymes maintained good stability and activity. At the same time, the variants exhibited dramatically reduced interaction with human class II major histocompatibility complex proteins, key regulators of anti-drug immune responses. When compared to 8-mutation designs generated with a sequence-based deimmunization algorithm, the structure-based designs retained greater thermostability and possessed fewer high affinity epitopes, the dominant drivers of anti-biotherapeutic immune responses. These experimental results validate the first structure-based deimmunization algorithm capable of mapping optimal biotherapeutic design space. By designing optimal mutations that reduce immunogenic potential while imparting favorable intramolecular interactions, broadly distributed epitopes may be simultaneously targeted using high mutational loads.
Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining (2015)

We developed highly accurate markers for the diagnosis of both NASH and NASH-related fibrosis (i.e., FM-NASH index and FM-fibro index, respectively). These markers may be used as an alternative diagnostic tool to liver biopsy.
Spontaneous Subthreshold Membrane Potential Fluctuations and Action Potential Variability of Rat Corticostriatal and Striatal Neurons In Vivo (1997)

We measured the timing of spontaneous membrane potential fluctuations and action potentials of medial and lateral agranular corticostriatal and striatal neurons with the use of in vivo intracellular recordings in urethan-anesthetized rats. All neurons showed spontaneous subthreshold membrane potential shifts from 7 to 32 mV in amplitude, fluctuating between a hyperpolarized down state and depolarized up state. Action potentials arose only during the up state. The membrane potential state transitions showed a weak periodicity with a peak frequency near 1 Hz. The peak of the frequency spectra was broad in all neurons, indicating that the membrane potential fluctuations were not dominated by a single periodic function. At frequencies >1 Hz, the log of magnitude decreased linearly with the log of frequency in all neurons. No serial dependence was found for up and down state durations, or for the time between successive up or down state transitions, showing that the up and down state transitions are not due to superimposition of noisy inputs onto a single frequency. Monte Carlo simulations of stochastic synaptic inputs to a uniform finite cylinder showed that the Fourier spectra obtained for corticostriatal and striatal neurons are inconsistent with a Poisson-like synaptic input, demonstrating that the up state is not due to an increase in the strength of an unpatterned synaptic input. Frequency components arising from state transitions were separated from those arising from the smaller membrane potential fluctuations within each state. A larger proportion of the total signal was represented by the fluctuations within states, especially in the up state, than was predicted by the simulations. The individual state spectra did not correspond to those of random synaptic inputs, but reproduced the spectra of the up and down state transitions. This suggests that the process causing the state transitions and the process responsible for synaptic input may be the same. A high-frequency periodic component in the up states was found in the majority of the corticostriatal cells in the sample. The average size of the component was not different between neurons injected with QX-314 and control neurons. The high-frequency component was not seen in any of our sample of striatal cells. Corticostriatal and striatal neurons' coefficients of variation of interspike intervals ranged from 1.0 to 1.9. When interspike intervals including a down state were subtracted from the calculation, the coefficient of variation ranged from 0.4 to 1.1, indicating that a substantial proportion of spike interval variance was due to the subthreshold membrane potential fluctuations.
A precision monolithic time delay generator for use in automotive electronic fuel injection systems (1972)

A high-performance low-cost IC time-delay generator has been developed to be used as a building block for automotive electronic fuel injection systems. Time-delay accuracies are achieved by employing the IC to precisely control both the reset time and the initial ramp voltage of an external RC voltage sweep circuit by means of a gated voltage regulator. Reference information, derived from the rotating distributor shaft, triggers an input flip-flop that controls a reset generator to produce the required gating pulses. The resulting exponential voltage sweep is sensed at the input of three externally programmable voltage comparators that provide three separate time-delayed output signals within a /spl plusmn/1-percent accuracy from -40/spl deg/ to +125/spl deg/C. This technique is contrasted to a linear voltage sweep approach which offers less desensitivity to IC parameter variations.
Long-range multilocus haplotype phasing of the MHC (2006)

Haplotypes are a powerful tool for identifying the genetic basis of common complex diseases. Disease-association mapping requires molecular methods for haplotyping biallelic SNP variation and highly complex polymorphisms. We developed a method for phasing HLA-A, HLA-B, and HLA-DRB1 alleles on chromosome 6 in unrelated individuals. This method uses the highly polymorphic HLA-B locus to discriminate the two HLA haplotypes in heterozygous individuals and its ideal location 1.4 Mbp telomeric to HLA-DRB1 and 1.2 Mbp centromeric to HLA-A to capture 2-Mbp-long genomic DNA. Genomic DNA representing a single HLA-B-captured haplotype is genotyped for HLA-A and HLA-DRB1 alleles and linkage to HLA-B is established. Proof of principle was established in a large blinded study of phase-known samples. Availability of an efficient method for MHC haplotype phase determination will facilitate the mapping of causative MHC-resident genes in many human diseases and has the potential to be broadened to other polymorphic gene complexes.
Violet light emitting diode‐induced fluorescence detection combined with on‐line sample concentration techniques for use in capillary electrophoresis (2003)

The first application of a violet light-emitting diode (LED) for fluorescence detection in capillary electrophoresis (CE) is described. The utility of violet LED (peak emission wavelength at 410 nm, approximately 2 mW) for fluorescence detection is demonstrated by examining reserpine and dopamine-labeled NDA (naphthalene-2,3-dicarboxaldehyde), respectively. The detection limit for reserpine was determined to be 2.5 x 10(-6) M by normal micellar electrokinetic capillary chromatography (MEKC) and this was improved to 2.0 x 10(-9) M and 2.0 x 10(-10) M when sweeping-MEKC and cation-selective exhaustive injection (CSEI)-sweep-MEKC techniques were applied, respectively. In addition, the detection limit of NDA-labeled dopamine was determined to be 6.3 x 10(-6) M by means of normal MEKC and this was improved to 3.0 x 10(-8) M when the sweeping-MEKC mode was applied.
Sensitive noninvasive marker for the diagnosis of probable bacterial or viral infection (2004)

Urinary trypsin inhibitor (uTi) is a product of elastase-mediated degradation of interleukin-alpha-inhibitor (I-alpha-I). Its activity increases in the urine of patients with a malignancy, inflammation, or infection, or in late pregnancy. The objective of this study was to compare the sensitivity of uTi in urine with that of serum quantitative C-reactive protein (CRP) for diagnosing infection, as indicated by white cell response and clinical assessment. Ninety controls and 171 patients with various systemic infections were enrolled. We measured uTi enzymatically on a Cobas Fara (Roche Diagnostics). Patients were separated into bacterial, probable bacterial, viral, or probable viral groups based on the results of a complete blood count with differential (CBC), urinalysis (UA), and clinical assessment. In the bacterial (n=70) and control (n=90) groups, the uTi values (mean+/-SE) were 25.3+/-3.1 mg/L and 2.8+/-0.8 mg/L, respectively. uTi (at 2.7 mg/L) had a diagnostic sensitivity of 91% and specificity of 82% (AUC=0.889), whereas CRP (at a cutoff of 10 mg/L) had a sensitivity and specificity of 82% and 96%, respectively (AUC=0.921). As a marker of infection (positive in both bacterial and viral groups), uTi had a sensitivity of 91% (AUC=0.884) vs. 89% (AUC=0.828) for CRP. Our data indicate that uTi has sufficient clinical sensitivity for screening systemic infections, and may have diagnostic value as a noninvasive test.
Ensuring Better Well Stimulation in Unconventional Oil and Gas Formations by Optimizing Surfactant Additives (2012)

Abstract Proper application of surfactant is critical to the completion process. It not only enhances initial production (IP), but helps sustain long-term production. Conventional wisdom suggests that the use of a nonemulsifying surfactant will work appropriately across most low-permeability reservoirs. Laboratory and field results, however, suggest that a weakly emulsifying surfactant is, in fact, far more efficient in solubilizing and mobilizing oil globules. In this paper, an experimental toolbox and key strategies are presented for properly selecting surfactants for specific reservoir conditions. Dynamic surface tension, emulsion tendency, oil recovery, wettability and adsorption tests were all considered to select the proper surfactant for the case study. On the basis of these results, the field performance of both the nonemulsifying and weakly emulsifying surfactants are evaluated using production data from the Eagle Ford. The production-enhancement data appears to correspond well to lab results and strongly suggests that weakly emulsifying surfactants are superior at enhancing production.
Study on strain-induced polarization mode of strained-layer quantum-well 630-nm AlGaInP LD's (1995)

Low-threshold operation of 630-nm AlGaInP LD's is examined by introducing compressive and tensile strains into quantum wells (QW's), and the dependence of threshold currents on the effects of strain is investigated. We also try to determine the correlation between the strain-induced polarization mode and threshold currents so as to optimize the strained QW structure for low threshold operation. Experimental results reveal a good correlation when the same device parameters are used. Based on that correlation, applying the larger strain and the QW-structure design that enhances the main polarization mode is effective in obtaining a low threshold. Opposite dependences of the relative intensity of the polarization mode on such device parameters as cavity length and facet reflectivity are observed under the two types of strain. Under tensile strain, the polarization-mode intensity increases as the mirror loss increases and the device temperature rises.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A laboratory study of the velocity structure in an intrusive gravity current (2002)

Laboratory experiments were performed in which an intrusive gravity current was observed using shadowgraph and particle tracking methods. The intrusion was generated in a two-layer fluid with a sharp interface by mixing the fluid behind a vertical lock gate and then suddenly withdrawing the gate from the tank. The purpose of the experiments was to determine the structure of the velocity field inside the intrusion and the stability characteristics of the interface. Soon after the removal of the lock gate, the front of the intrusive gravity current travelled at a constant speed close to the value predicted by theory for an energy-conserving gravity current. The observed structure of the flow inside the intrusion can be divided into three regions. At the front of the intrusion there is an energy-conserving head region in which the fluid velocity is nearly uniform with speed equal to the front speed. This is followed by a dissipative wake region in which large billows are present with their associated mixing and in which the fluid velocity is observed to be non-uniform and have a maximum speed approximately 50% greater than the front speed. Behind the wake region is a tail region in which there is very little mixing and the velocity field is nearly uniform with a speed slightly faster than the front speed.
HIV infection leads to differential expression of T-cell receptor Vβ genes in CD4+ and CD8+ T cells (1993)

HIV-1 infection induces CD4+ T-cell deficiency, both in total numbers and by causing a paucity of select V beta gene expression in this subset. In addition, the V beta 3 gene family was deleted or underexpressed was observed in both CD4+ and CD8+ T-cell subsets from patients in CDC stage IV. These results are compatible with changes in V beta gene expression known to occur under the action of endogenous or exogenous superantigens.
Solid State Electrolytes Prepared from PEO (360) Silanated Silica (2002)

All solid state composite electrolytes were prepared using fumed silica (SiO2) silanated with an oligomeric polyethylene oxide (PEO) silane containing 6-9 ethylene oxide repeat units, a PEO matrix and LiClO4 (8/1 O/Li). The PEO-silane covalently attached to the silica was amorphous, with a T(sub g) that increased from -90 C to -53 C after attachment. The conductivity of films prepared using the PEO-silanated silica increased to approx. 6 x 10(exp -5) S/cm at RT compared with approx. 1 x 10(-5) S/cm for films prepared with unsilanated SiO2.
Music identification via vocabulary tree with MFCC peaks (2011)

In this paper, a Vocabulary Tree based framework is proposed for music identification whose target is to recognize a fragment from a song database. The key to a high recognition precision within this framework is a novel feature, namely MFCC Peaks, which is a combination of MFCC and Spectral Peaks features. Our approach consists of three stages. We first build the Vocabulary Tree with 2 million MFCC Peaks features extracted from hundreds of music. Then each song in the database is quantified into some words by traveling from root down to a certain leaf. Given a query input, we apply the same quantization procedure to this fragment, score the archive according to the TF-IDF scheme and return the best matches. The experimental results demonstrate that our proposed feature has strong identifying and generalization ability. Other trials show that our approach scales well with the size of database. Further comparison also demonstrates that while our algorithm achieves approximately the same retrieval precision as other state-of-the-art methods, it cost less time and memory.
Gastrin gene expression and regulation in rat islet cell lines. (1988)

Gastrin gene expression was observed in two permanent rat insulinoma (RIN) cell lines derived from a rat insulinoma. Gastrin expression was selective; highest expression was seen in a cell line which did not express other islet cell hormones. Gastrin mRNA transcription initiated from the same promoter as antral gastrin mRNA. DNA transfection studies with a gastrin chloramphenicol acetyltransferase chimeric gene showed higher expression in gastrin-expressing RIN cells than non-gastrin-expressing islet cells. This implies that gastrin-expressing RIN cells selectively express a trans-acting transcriptional activator which binds to cis-acting regulatory sequences within the 5'-flanking DNA sequence and first exon of the gastrin gene. The gastrin peptide precursor synthesized in these RIN cell lines is subject to the same repertoire of posttranslational modifications within the cell's secretory apparatus (endoproteolytic cleavage, tyrosine sulfation, and C-terminal amidation) as seen in antral G cells. Gastrin mRNA levels in these RIN cells were selectively increased by increasing the extracellular calcium concentration. Membrane depolarization also stimulated gastrin mRNA levels, probably through activation of voltage-sensitive calcium channels. Thus, these gastrin-expressing RIN cell lines provide permanent cell lines useful in analyzing the cellular regulation of gastrin gene expression.