gebhart/patrepeval huggingface dataset:
Enhanced model for Lithium-Polymer cells including temperature effects (2010)

An accurate model of the elementary accumulation device is fundamental for sizing and controlling the battery pack to be used in electric and hybrid vehicles. Indeed, the implementation of such a model within the Battery Management System makes it possible to evaluate the status and the behavior of the battery pack in every condition and to apply a correct control strategy. This work shows the characterization and modeling of a commercial Lithium-Polymer cell, which properly considers thermal effects on cell behavior. The specific designed thermostatic chamber is described and the experimental results are presented and compared to those simulated with the developed model.
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70 (1998)

The Wilms tumor suppressor WT1 encodes a zinc finger transcription factor that is expressed in glomerular podocytes during a narrow window in kidney development. By immunoprecipitation and protein microsequencing analysis, we have identified a major cellular protein associated with endogenous WT1 to be the inducible chaperone Hsp70. WT1 and Hsp70 are physically associated in embryonic rat kidney cells, in primary Wilms tumor specimens and in cultured cells with inducible expression of WT1. Colocalization of WT1 and Hsp70 is evident within podocytes of the developing kidney, and Hsp70 is recruited to the characteristic subnuclear clusters that contain WT1. The amino-terminal transactivation domain of WT1 is required for binding to Hsp70, and expression of that domain itself is sufficient to induce expression of Hsp70 through the heat shock element (HSE). Substitution of a heterologous Hsp70-binding domain derived from human DNAJ is sufficient to restore the functional properties of a WT1 protein with an amino-terminal deletion, an effect that is abrogated by a point mutation in DNAJ that reduces binding to Hsp70. These observations indicate that Hsp70 is an important cofactor for the function of WT1, and suggest a potential role for this chaperone during kidney differentiation.
A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma (2015)

Chemokines (CKs), small proinflammatory chemoattractant cytokines that bind to specific G-protein coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. C-X-C chemokine receptor type 4 (CXCR4) has gained tremendous attention over the last decade, since it was found to be upregulated in a wide variety of cancer types, including hepatocellular carcinoma (HCC). The clinical relevance of expression of CXCR4 in HCC remains controversial; our aim was to identify the precise relationship of CXCR4 to prognosis and clinicopathological features. We searched the database from MEDLINE, PubMed, Web of Science, Scopus and Embase and then conducted a meta-analysis from publications met the inclusion criteria for the qualitative study. Our data showed that 1) CXCR4 is overexpressed in HCC tissues but not in normal hepatic tissue, OR = 84.26, 95% confidence interval (CI) = 11.86-598.98, P < 0.0001. CXCR4 expression is higher in HCC than those in cirrhosis as well, OR = 20.71, 95% CI = 7.61-56.34, P < 0.00001. 2) The expression levels of CXCR4 does not increase during local progression, however, CXCR4 expression increases the risk of distant metastases in HCC, OR = 5.84, 95% CI = 2.84-12.00, P < 0.00001. 3) High levels of CXCR4 gene expression are associated with worse survival in HCC, HR = 0.18, 95% CI = 0.10-0.32, Z = 5.77, P < 0.00001. These data indicate that CXCR4 expression correlates with an increased risk and worse survival in HCC patients. The aberrant CXCR4 expression plays an important role in the carcinogenesis and metastasis of HCC. Our conclusion also supports that the promise of CXCR4 signaling pathway blockade as a potential strategy for HCC patients.
Observation of Extremely Low Defect Densities in Silicon Wafers (1999)

Defects in p - polished silicon wafers originating from Czochralski (Cz)-pulled crystals are commonly delineated by hot SC1 treatment with immersion times in the range from about 20 min to 4 h corresponding to silicon removals of 20 nm to 200 nm. This procedure is no longer applicable for wafers with defect densities that are orders of magnitude lower than in Cz p - wafers due to their very low count rates. However, a low defect density, such as in homoepitaxial silicon layers, can be investigated by sequentially treating wafers in hot SC1 solution several times so that the overall duration of the preparation is on the order of twenty hours resulting in a silicon removal of about 1 µm. Defects delineated by hot SC1 etching can, in addition, be investigated with an atomic force microscope. In the case of homoepitaxial silicon layers, these defects are identified as single as well as dual pits with a morphology characteristic of so-called crystal originated particles (COPs) as observed on p - Cz wafers. These COPs are related to voids generated by vacancy agglomeration in the growing ingot. The morphology of the delineated defects indicates that such voids exist in homoepitaxial layers as well, which is supported by the fact that the temperature range relevant for void formation in p - Cz silicon crystals is also used in silicon homoepitaxial growth. The oxygen backpressure during homoepitaxial silicon growth is negligible. Thus, formation of voids in the epitaxial layer is not influenced by oxygen, specifically when an oxygen-free silicon substrate, such as a wafer cut from a floating-zone (FZ) crystal, is used. However, not only single but also dual-pit COPs are observed on such epitaxial layers after delineation, which questions assumptions and models in the literature attributing the formation of multiple voids in p - Cz silicon crystals to the role of oxygen.
The Gastric Antiulcer Effects of the Leaves of the<i>Neem</i>Tree (1993)

The antiulcer effect of aqueous extracts of the leaves of the neem tree was investigated in rats exposed to 2-h cold-restraint stress or given ethanol orally for 1 h. Extracts were administered in doses of 10, 40, or 160 mg leaf/kg body weight, either as single- or five-dose pretreatment regimens. Neem dose-dependently reduced gastric ulcer severity in rats subjected to stress and also decreased ethanol provoked gastric mucosal damage. The extract appeared to prevent mast cell degranulation and to increase the amount of adherent gastric mucus in stressed animals. These effects may explain, at least in part, the mode of the antiulcer action of neem.
CommBridge ¾ An Enterprise Application Integration Architecture for Electronic Government (1998)

This study uncovers that TEC ferroptosis may promote interstitial fibrosis and inflammation, and targeting ferroptosis may shine a light on protecting against kidney fibrosis in patients with CKDs.
Intrarenal AT<sub>1</sub>receptor and ACE binding in ANG II-induced hypertensive rats (2002)

The intrarenal expression of angiotensin II (ANG II) type 1 (AT(1)) receptors and angiotensin-converting enzyme (ACE) was determined in ANG II-induced hypertensive rats (80 ng/min; 2 wk). Systolic blood pressure averaged 184 +/- 3 and 125 +/- 1 mmHg in ANG II-infused compared with Sham rats on day 12. Total kidney AT(1) receptor protein levels were not altered significantly. AT(1) receptor binding mapped by quantitative in vitro autoradiography was significantly decreased in glomeruli (172 +/- 25 vs. 275 +/- 34 disintegrations. min(-1). mm(-2)) and the inner stripe of the outer medulla (121 +/- 17 vs. 178 +/- 19 disintegrations. min(-1). mm(-2)), but not proximal convoluted tubules (48 +/- 9 vs. 58 +/- 6 disintegrations. min(-1). mm(-2)) of ANG II-infused compared with Sham rats. Proximal tubule ACE binding was significantly augmented (132 +/- 4 vs. 97 +/- 3 disintegrations. min(-1). mm(-2)) in ANG II-infused rats. In summary, during ANG II-induced hypertension, glomeruli and inner stripe of the outer medulla have reduced AT(1) receptor binding. Proximal convoluted tubules exhibit maintained AT(1) receptor density and increased ACE binding, which together with the elevated ANG II levels suggest that ANG II exerts a sustained influence on tubular reabsorption and consequently contributes to the development and maintenance of ANG II-dependent hypertension.
Identifying First-Person Camera Wearers in Third-Person Videos (2017)

We consider scenarios in which we wish to perform joint scene understanding, object tracking, activity recognition, and other tasks in scenarios in which multiple people are wearing body-worn cameras while a third-person static camera also captures the scene. To do this, we need to establish person-level correspondences across first-and third-person videos, which is challenging because the camera wearer is not visible from his/her own egocentric video, preventing the use of direct feature matching. In this paper, we propose a new semi-Siamese Convolutional Neural Network architecture to address this novel challenge. We formulate the problem as learning a joint embedding space for first-and third-person videos that considers both spatial-and motion-domain cues. A new triplet loss function is designed to minimize the distance between correct first-and third-person matches while maximizing the distance between incorrect ones. This end-to-end approach performs significantly better than several baselines, in part by learning the first-and third-person features optimized for matching jointly with the distance measure itself.
Selective Breeding of Microbial Strain with High Yield of L-lactic Acid by Ion Implantation (2004)

A study was made on Lactobacilkis casei LllOZ with the production of L-lactic acid by the technology of ion implantation.The result showed that the optimal mutagenic effect was at the ion dose of 1×10~(14)N~(+) per cm~(2). After lots of screening tests,a mutant strain was obtained named L110Z5 whose activity of L- lactic acid about 18.0% higher than that of the original strain L110Z. And it was found that the yield of L-lactic acid by the strain LI 10Z5 was rather stable througli successive transfer of cultures. It showed that the strain LI 10Z5 with higher yield of L -lactic acid had good prospect in industrial application.
Pharmacology of the new selective A2a adenosine receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine. (1994)

The pharmacological profile of 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA, CAS 141018-30-6), a new selective A2a adenosine receptor agonist, was characterized. In binding studies on both rat and bovine brain, 2HE-NECA was more potent on A2a receptors (Ki = 2.2 and 1.5 nmol/l, respectively) than the reference A2a agonist, 2-[4-(2-carboxyethyl)-phenethylamino]-5'-N-ethylcarboxamidoaden osi ne (CPEC) or the non-selective adenosine agonist 5'-N-ethylcarboxamidoadenosine (NECA). The drug displayed a good A2a vs A1 receptor selectivity in brain tissues of both animal species (60- and 160-fold, respectively). In functional studies, 2HE-NECA showed marked vasodilating properties in rat aorta, bovine and porcine coronary arteries. The vasodilatory response in the porcine coronary preparation was greater for 2HE-NECA (EC50 = 23.3 nmol/l) than for CPEC (EC50 = 58.7 nmol/l) or NECA (EC50 = 76.6 nmol/l). In the rat Langendorff model, in which global ischemia was induced, 2HE-NECA (100 nmol/l) significantly prevented the risk of diastolic pressure and coronary perfusion pressure occurring during postischemic reperfusion. The in vitro antiaggregatory activity of 2HE-NECA (IC50 = 0.07 mumol/l), as tested in rabbit platelets, was higher than that found with NECA (IC50 = 0.2 mumol/l) or CPEC (IC50 = 2.16 mumol/l). In spontaneously beating rat atria, which are responsive to A1-receptor stimulation, 2HE-NECA did not show any negative chronotropic activity up to micromolar concentrations. In conscious spontaneously hypertensive rats, 2HE-NECA administered intraperitoneally caused a dose-dependent reduction in systolic blood pressure (ED30 = 0.005 mg/kg) with minimal reflex tachycardia.(ABSTRACT TRUNCATED AT 250 WORDS)
Genome assembly with in vitro proximity ligation data and whole-genome triplication in lettuce (2017)

Lettuce (Lactuca sativa) is a major crop and a member of the large, highly successful Compositae family of flowering plants. Here we present a reference assembly for the species and family. This was generated using whole-genome shotgun Illumina reads plus in vitro proximity ligation data to create large superscaffolds; it was validated genetically and superscaffolds were oriented in genetic bins ordered along nine chromosomal pseudomolecules. We identify several genomic features that may have contributed to the success of the family, including genes encoding Cycloidea-like transcription factors, kinases, enzymes involved in rubber biosynthesis and disease resistance proteins that are expanded in the genome. We characterize 21 novel microRNAs, one of which may trigger phasiRNAs from numerous kinase transcripts. We provide evidence for a whole-genome triplication event specific but basal to the Compositae. We detect 26% of the genome in triplicated regions containing 30% of all genes that are enriched for regulatory sequences and depleted for genes involved in defence.
The global burden of neurologic diseases (2014)

WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory diseases. Deaths from communicable diseases, such as HIV/AIDS, tuberculosis, and malaria, are declining as a result of billions of dollars of annual international and domestic funding that target the prevention and treatment of these diseases. In recent years, less than 3% of official development assistance for health has been directed toward NCD.3 However, when measured in disability-adjusted life-years (DALY), NCD accounted for 54% of the global burden of disease in 2010, compared to 43% in 1990.1 DALY are the sum of 2 components: years of life lost due to premature mortality and years lived with disability. One DALY is the equivalent of one healthy life-year lost (for a complete definition of DALY, see reference 1). DALY are a particularly useful metric to quantify the burden of NCD (e.g., stroke) that often result in long-term disability for survivors.
Real-Time Stereo Matching on CUDA Using an Iterative Refinement Method for Adaptive Support-Weight Correspondences (2012)

High-quality real-time stereo matching has the potential to enable various computer vision applications including semi-automated robotic surgery, teleimmersion, and 3-D video surveillance. A novel real-time stereo matching method is presented that uses a two-pass approximation of adaptive support-weight aggregation, and a low-complexity iterative disparity refinement technique. Through an evaluation of computationally efficient approaches to adaptive support-weight cost aggregation, it is shown that the two-pass method produces an accurate approximation of the support weights while greatly reducing the complexity of aggregation. The refinement technique, constructed using a probabilistic framework, incorporates an additive term into matching cost minimization and facilitates iterative processing to improve the accuracy of the disparity map. This method has been implemented on massively parallel high-performance graphics hardware using the Compute Unified Device Architecture computing engine. Results show that the proposed method is the most accurate among all of the real-time stereo matching methods listed on the Middlebury stereo benchmark.
An Experimental Approach to Nonlinear Dynamics and Chaos. (1993)

This essential handbook provides the theoretical and experimental tools necessary to begin researching the nonlinear behavior of mechanical, electrical, optical, and other systems. The book describes several nonlinear systems which are realized by desktop experiments, such as an apparatus showing chaotic string vibrations, an LRC circuit displaying strange scrolling patterns, and a bouncing ball machine illustrating the period doubling route to chaos. Fractal measures, periodic orbit extraction, and symbolic analysis are applied to unravel the chaotic motions of these systems. The simplicity of the examples makes this an excellent book for undergraduate and graduate-level physics and mathematics courses, new courses in dynamical systems, and experimental laboratories.
Magnitude of benefit from earlier thrombolytic treatment in acute myocardial infarction: new evidence from Grampian region early anistreplase trial (GREAT) (1996)

The magnitude of the benefit from earlier thrombolysis is such that giving thrombolytic treatment to patients with acute myocardial infarction should be accorded the same degree of urgency as the treatment of cardiac arrest.
Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+. (1993)

This paper reports an investigation on the minimal requirements for induction of the mitochondrial cyclosporin A-sensitive permeability transition pore (MTP). Energized rat liver mitochondria incubated in sucrose medium take up a Ca2+ pulse but do not show activation of the MTP upon addition of fully uncoupling concentrations of carbonyl cyanide-p-trifluoromethoxy-phenyl hydrazone (FCCP). Yet, addition of ruthenium red immediately prior to FCCP or inclusion of acetate or low concentrations of phosphate in the incubation medium restore the ability of FCCP to trigger MTP opening. Since ruthenium red, phosphate, or acetate do not induce the MTP per se, they must act upon some additional factor(s) that counteract the increase of pore "open" probability induced by membrane depolarization (Bernardi, P. (1992) J. Biol. Chem. 267, 8834-8839). We show that two key factors determining the overall probability of pore opening are matrix pH and matrix [Ca2+] when the membrane is depolarized. Indeed, in the absence of ruthenium red, phosphate, or acetate the addition of FCCP is followed by fast Ca2+ efflux on the uniporter mirrored by intense matrix acidification following compensatory H+ influx via FCCP. Ruthenium red prevents both Ca2+ efflux and matrix acidification, acetate mainly prevents matrix acidification, and phosphate both slows down Ca2+ efflux and prevents matrix acidification. Taken together, our data indicate that membrane depolarization is both necessary and sufficient to trigger MTP opening when matrix acidification and rapid Ca2+ efflux are prevented. Thus, the wide variety of MTP "inducing agents" may largely reflect the wide variety of the possible combinatorial effects on the minimal requirements for MTP operation.
Using importance flooding to identify interesting networks of criminal activity (2008)

Abstract Effectively harnessing available data to support homeland‐security‐related applications is a major focus in the emerging science of intelligence and security informatics (ISI). Many studies have focused on criminal‐network analysis as a major challenge within the ISI domain. Though various methodologies have been proposed, none have been tested for usefulness in creating link charts. This study compares manually created link charts to suggestions made by the proposed importance‐flooding algorithm. Mirroring manual investigational processes, our iterative computation employs association‐strength metrics, incorporates path‐based node importance heuristics, allows for case‐specific notions of importance, and adjusts based on the accuracy of previous suggestions. Interesting items are identified by leveraging both node attributes and network structure in a single computation. Our data set was systematically constructed from heterogeneous sources and omits many privacy‐sensitive data elements such as case narratives and phone numbers. The flooding algorithm improved on both manual and link‐weight‐only computations, and our results suggest that the approach is robust across different interpretations of the user‐provided heuristics. This study demonstrates an interesting methodology for including user‐provided heuristics in network‐based analysis, and can help guide the development of ISI‐related analysis tools.
Aqueous Synthesis of CdTe Quantum Dot Using Dithiol‐Functionalized Ionic Liquid (2012)

We report on an aqueous synthesis of cadmium telluride (CdTe) nanocrystals by using dithiol‐functionalized ionic liquids (dTFILs). The dTFILs were designed to have dithiol and vinylimidazolium functional groups and used as a ligand molecule of CdTe quantum dot (QD) to utilize the bidendate chelate interaction afforded by the dithiol groups of dTFILs. The photoluminescence quantum yield of dTFIL‐capped CdTe QDs reached up to ~40%, and their luminescent property was maintained for 8 weeks, suggesting an improved stability in water phase. This approach will provide a new synthetic route to the water soluble QDs.
[Diagnostic value of nasal secretions, current state: normal values. 1]. (1983)

Separation of pure nasal secretions has been very difficult until now. Therefore, examinations were performed only with a small number of patients. Employing a new method to separate pure nasal secretions it is now possible to perform routine examinations. In this paper the protein composition and electrolyte patterns of normal human nasal secretion is reported. The amount of nasal secretion depends from the location and region of human nasal mucosa. The average amount is between 135 and 75 microliters. The protein concentration shows a very wide variation in the normal secretion between 200 and 3500 mg%. The average concentration in the upper nasal meatus is 950 mg%, in the lower nasal meatus 1100 mg%. Selective glycoprotein stainings show that the main part of nasal secret proteins are glycoproteins. The electrolyte concentrations were calculated for sodium 90-148 mval, potassium 6-28 mval and calcium 2-3.5 mval.
IC design on the World Wide Web (1998)

A design log-jam is imminent. By 2001, designers of a single application-specific IC may have over 100 million transistors at their beck and call, according to the US Semiconductor Industry Association's National Roadmap for Semiconductors. Chip designs will rarely be home grown-instead, they will be organized around elements the design team acquires from others, either from companies that specialize in developing so-called intellectual property or from the reuse of blocks previously developed within the same or another organization. This paper describes how the rising tide of Web-based tools and services augurs the next sea change in electronic design.
ChemInform Abstract: A Simple and Efficient Synthesis of cis‐Bicyclo(3.3.0)oct‐6‐en‐2‐one and Related Compounds. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.