gebhart/patrepeval huggingface dataset:
Pharmacological Targets for the Inhibition of Neurogenic Inflammation (2003)

Neuropeptides released from the activated peripheral terminals of capsaicin-sensitive subpopulation of sensory neurons exert local efferent function besides the classical afferent activity. This substantial population of nociceptive afferents expess the capsaicin (vanilloid subtype 1) VR1 / TRPV1 receptor, which is a noxious heat / proton-gated cation channel. Calcitonin gene-related peptide (CGRP) increases local blood flow by inducing arteriolar vasodilatation, substance P (SP) and neurokinin A cause plasma protein extravasation due to increased microvascular permeability and accumulation of inflammatory cells via neurokinin 1 (NK1) receptors in the innervated area. This set of pathophysiological changes initiated by sensory nerve endings is defined as neurogenic inflammation, which plays significant role in the pathomechanism of numerous diseases like bronchial asthma, allergic rhinitis, conjunctivitis and dermatitis, ekzema, psoriasis, rheumatoid arthritis and migraine. The major problem in the treatment of these conditions is the lack of effective therapy for the neurogenic component of inflammatory processes. Potential ways to inhibit neurogenic inflammation are decreasing the release of inflammatory neuropeptides and / or preventing their effects by receptor antagonists on blood vessels and inflammatory cells. Prejuntional inhibition can be performed by opioid peptides acting mainly on μ receptor, nociceptin through opioid receptor like 1 (ORL1 / OP4) receptor, histamine via H3 receptor, 5-hydroxytryptamine via 5-HT1B / 1D receptor, α2-adrenoceptor agonists, galanine, purine derivatives and somatostatin. According to our results somatostatin released into the circulation from activated sensory nerve terminals exerts systemic antiinflammatory and analgesic actions. Nitric oxide (NO) has been reported to liberate neuropeptides from sensory nerves, selective inhibitor of inducible NO synthase would also be a possibility to inhibit the release of mediators. Several results suggest that potent synthetic CGRP and NK1 receptor antagonists acting on the target tissues are effective in the management of neurogenic oedema formation. VR1 / TRPV1 receptor is at present a hot topic to develop novel analgesic / anti-inflammatory drugs acting on the nociceptors. This receptor can be activated by capsaicin, resiniferatoxin, protons, noxious heat, the endocannabinoid anandamide, and lipoxygenase products. Efforts to develop VR1 antagonists are in progress in major drug companies and the promising experimental evidence obtained in our laboratories favours agents acting on somatostatin receptors, which do not mediate endocrine effects. Potential targets on sensory nerve terminals for the development of new anti-inflammatory drugs are summarized in this review with special emphasis on VR1 receptors and somatostatin analogs. Keywords: capsaicin-sensitive primary sensory neurons, neurogenic inflammation, vanilloid receptor 1, somatostatin, opioid peptides, cannabinoid receptors, substance p, calcitonin gene-related peptide
Accelerated Acquisition of High-resolution Diffusion-weighted Imaging of the Brain with a Multi-shot Echo-planar Sequence: Deep-learning-based Denoising (2020)

To accelerate high-resolution diffusion-weighted imaging with a multi-shot echo-planar sequence, we propose an approach based on reduced averaging and deep learning. Denoising convolutional neural networks can reduce amplified noise without requiring extensive averaging, enabling shorter scan times and high image quality. The preliminary experimental results demonstrate the superior performance of the proposed denoising method over state-of-the-art methods such as the widely used block-matching and 3D filtering.
Edge-preserving image resizing using modified B-splines (2002)

An edge-preserving method for image resizing (decimation and interpolation) is proposed. The decimation is considered as an orthogonal projection with respect to the chosen interpolation basis. The latter one is formed in a spline-like manner as a linear combination of B-splines of different degrees. This combination is optimized in such a way that the small image details are preserved. Considering the strongest edges as step edges, a segmentation procedure preceding the decimation is proposed. It leads to resized images with clearly outlined borders.
Novel method for high-throughput phenotyping of sleep in mice (2006)

Assessment of sleep in mice currently requires initial implantation of chronic electrodes for assessment of electroencephalogram (EEG) and electromyogram (EMG) followed by time to recover from surgery. Hence, it is not ideal for high-throughput screening. To address this deficiency, a method of assessment of sleep and wakefulness in mice has been developed based on assessment of activity/inactivity either by digital video analysis or by breaking infrared beams in the mouse cage. It is based on the algorithm that any episode of continuous inactivity of > or =40 s is predicted to be sleep. The method gives excellent agreement in C57BL/6J male mice with simultaneous assessment of sleep by EEG/EMG recording. The average agreement over 8,640 10-s epochs in 24 h is 92% (n = 7 mice) with agreement in individual mice being 88-94%. Average EEG/EMG determined sleep per 2-h interval across the day was 59.4 min. The estimated mean difference (bias) per 2-h interval between inactivity-defined sleep and EEG/EMG-defined sleep was only 1.0 min (95% confidence interval for mean bias -0.06 to +2.6 min). The standard deviation of differences (precision) was 7.5 min per 2-h interval with 95% limits of agreement ranging from -13.7 to +15.7 min. Although bias significantly varied by time of day (P = 0.0007), the magnitude of time-of-day differences was not large (average bias during lights on and lights off was +5.0 and -3.0 min per 2-h interval, respectively). This method has applications in chemical mutagenesis and for studies of molecular changes in brain with sleep/wakefulness.
Cell coverage area information service to improve cell selection in HetNets (2014)

Information services providing diverse information about networks and their services have been widely cited as one of the key factors to better utilize the heterogeneous network environment. However, the current information services do not properly enable determining the base stations that reside within the range and close-by of a mobile device. The serving range of base stations can only be roughly estimated. Moreover, large variation in cell sizes bring additional challenges with respect to mobility management. In this study, a network information service allowing mobile devices to query for information about base station cells near their location is utilized in cell selection. A spatial database is used to store the coverage area geometries of base stations and the base station coverage area and distance information is utilized in cell selection. The paper presents a clustering method for grouping the cells found in the vicinity of a mobile terminal based on the coverage area and their distance to the terminal, which improves the handover target discovery in a dense cell environment. In pedestrian mobility, mobile network operators likely prefer the use of cells with short range for traffic load balancing purposes. Favoring large cells in the high-speed vehicular mobility, the results show that the number of handovers can be significantly decreased, even cut to half from that attained with the conventional cell selection scheme.
A Rapid and Sensitive Aptamer‐Based Electrochemical Biosensor for Direct Detection of <i>Escherichia Coli</i> O111 (2012)

Abstract A sensitive and specific electrochemical biosensor based on target‐induced aptamer displacement was developed for direct detection of Escherichia coli O111. The aptamer for Escherichia coli O111 was immobilized on a gold electrode by hybridization with the capture probe anchored on the electrode surface through Au‐thiol binding. In the presence of Escherichia coli O111, the aptamer was dissociated from the capture probe‐aptamer duplex due to the stronger interaction between the aptamer and the Escherichia coli O111. The consequent single‐strand capture probe could be hybridized with biotinylated detection probe and tagged with streptavidin‐alkaline phosphatase, producing sensitive enzyme‐catalyzed electrochemical response to Escherichia coli O111. The designed biosensor showed weak electrochemical signal to Salmonella typhimurium , Staphylococcus aureus and common non‐pathogenic Escherichia coli , indicating high specificity for Escherichia coli O111. Under the optimal conditions, the proposed strategy could directly detect Escherichia coli O111 with the detection limit of 112 CFU mL −1 in phosphate buffer saline and 305 CFU mL −1 in milk within 3.5 h, demonstrated the sensitive and accurate quantification of target pathogenic bacteria. The designed biosensor could become a powerful tool for pathogenic microorganisms screening in clinical diagnostics, food safety, biothreat detection and environmental monitoring.
[The specific features of imported Plasmodium vivax malaria, Chesson strain type]. (2013)

The details of imported case of Chesson strain of P. vivax malaria to Russian Federation (Moscow) from border areas between Myanmar and Thailand is given. It might further confirm the expansion of this strain from its original place in the Western Pacific towards other territories in the World, described in various publications.
Discovery of Halopyridines as Quiescent Affinity Labels: Inactivation of Dimethylarginine Dimethylaminohydrolase (2011)

In an effort to develop novel covalent modifiers of dimethylarginine dimethylaminohydrolase (DDAH) that are useful for biological applications, a set of "fragment"-sized inhibitors that were identified using a high-throughput screen are tested for time-dependent inhibition. One structural class of inactivators, 4-halopyridines, show time- and concentration-dependent inactivation of DDAH, and the inactivation mechanism of one example, 4-bromo-2-methylpyridine (1), is characterized in detail. The neutral form of halopyridines is not very reactive with excess glutathione. However, 1 readily reacts, with loss of its halide, in a selective, covalent, and irreversible manner with the active-site Cys249 of DDAH. This active-site Cys is not particularly reactive (pK(a) ca. 8.8), and 1 does not inactivate papain (Cys pK(a) ca. ≤4), suggesting that, unlike many reagents, Cys nucleophilicity is not a predominating factor in selectivity. Rather, binding and stabilization of the more reactive pyridinium form of the inactivator by a second moiety, Asp66, is required for facile reaction. This constraint imparts a unique selectivity profile to these inactivators. To our knowledge, halopyridines have not previously been reported as protein modifiers, and therefore they represent a first-in-class example of a novel type of quiescent affinity label.
Full wave synthetic acoustic logs in saturated porous media (1984)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1984Full wave synthetic acoustic logs in saturated porous mediaAuthors: D. P. SchmittM. BouchonD. P. SchmittUniv. de Grenoble/SNEA(P) and M. BouchonUniv. de Grenoble, Francehttps://doi.org/10.1190/1.1894352 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1894352FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1984ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1984 Pages: 856 publication data© 1984 Copyright © 1984 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 24 Mar 2005 CITATION INFORMATION D. P. Schmitt and M. Bouchon, (1984), "Full wave synthetic acoustic logs in saturated porous media," SEG Technical Program Expanded Abstracts : 17-20. https://doi.org/10.1190/1.1894352 Plain-Language Summary PDF DownloadLoading ...
M3D-RPN: Monocular 3D Region Proposal Network for Object Detection (2019)

Understanding the world in 3D is a critical component of urban autonomous driving. Generally, the combination of expensive LiDAR sensors and stereo RGB imaging has been paramount for successful 3D object detection algorithms, whereas monocular image-only methods experience drastically reduced performance. We propose to reduce the gap by reformulating the monocular 3D detection problem as a standalone 3D region proposal network. We leverage the geometric relationship of 2D and 3D perspectives, allowing 3D boxes to utilize well-known and powerful convolutional features generated in the image-space. To help address the strenuous 3D parameter estimations, we further design depth-aware convolutional layers which enable location specific feature development and in consequence improved 3D scene understanding. Compared to prior work in monocular 3D detection, our method consists of only the proposed 3D region proposal network rather than relying on external networks, data, or multiple stages. M3D-RPN is able to significantly improve the performance of both monocular 3D Object Detection and Bird's Eye View tasks within the KITTI urban autonomous driving dataset, while efficiently using a shared multi-class model.
Influence of the Corticosterone Rhythm on Photic Entrainment of Locomotor Activity in Rats (2004)

The question of involvement of glucocorticoid hormones as temporal signals for the synchronization of the timekeeping system was addressed in rats with different corticosterone status. The authors showed that adrenalectomy had no effects on the synchronization of wheel-running activity rhythms to a steady-state LD 12:12 cycle, regardless of whether it was compensated for by a corticosterone replacement therapy that either reinstated constant plasma concentrations of the hormone or mimicked its natural rhythm. However, after a 12-h phase shift (daylight reversal), the lack of circulating corticosterone induced a significant shortening of the resynchronization rate (less than 3 days vs. 7 days). Normalization required restoration of a rhythmic corticosterone secretion that was synchronized to the new photoperiod. Under constant darkness, the corticosterone rhythm did not show any synchronizing effect, providing evidence that it participates in entrainment of the locomotor activity rhythm through modulation of light effects. It is proposed that, under stable lighting conditions, circulating glucocorticoids contribute to stabilizing activity rhythms by reinforcing resistance of the circadian timing system to variations of the photoperiod. Experimental evidence that serotonergic neurons are involved in relaying their modulatory effects to the clock is also presented.
Perylene Polyimide-Polyether Anodes for Aqueous All-Organic Polymer Batteries (2018)

Aqueous batteries are a safe, sustainable, and a low cost alternative to store energy. Thus, there is an ongoing search for new battery electrode materials with redox potentials in the voltage range corresponding to the electrochemical stability window of water. Particularly, organic materials are attracting considerable attention due to their environmental friendliness and sustainability. While significant progress has been achieved in developing organic cathode materials, developing anode materials with good electrochemical performance remains a challenge. Here we show that perylene polyimides with oligoether groups are great anode candidates for high power aqueous polymer batteries. Perylene-based polyimide presents a redox reaction at −0.55 V vs Ag/AgCl and stable cycle life at high current density (600C) for 2000 cycles. An all-organic cell consisting of perylene polyimide-polyether as anode (negative electrode) and PEDOT-lignin biopolymer composite as cathode (positive electrode) has an output voltage of 1.0 V. The full-cell delivers 40 mAh g–1 discharge capacity at 100C with 85% capacity retention and above 93% Coulombic efficiency for 800 cycles.
ETS's English Composition Test. (1970)

An analysis of the kinds of sentences used by students in sample ETS English Composition Test essays, and a survey of some of the actual weaknesses of these papers (e.g., shifting subjects, use cf incorrect idiom, and inaccurate or incorrect word choices or usages) point to real gaps in student writing skills. Elements found in good papers (e.g., effective paragraphing, use cf quotation to support a point, use of rhetorical questions, use of illustrations, and effective parallel structures) should provide both goals and methods for strengthening writing proficiency. Some specific teaching techniques for improving composition quality include (1) greater emphasis on the improvement of simple sentences before attempting a mastery of compound or complex forms (2) adoption of the methods cf the Christensen Rhetoric Program (generative rhetoric), and (3) relating oral usage and the oral approach to
Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer<i>in vivo</i> (2012)

Cancer may result from localized failure of instructive cues that normally orchestrate cell behaviors toward the patterning needs of the organism. Steady-state gradients of transmembrane voltage (V(mem)) in non-neural cells are instructive, epigenetic signals that regulate pattern formation during embryogenesis and morphostatic repair. Here, we review molecular data on the role of bioelectric cues in cancer and present new findings in the Xenopus laevis model on how the microenvironment's biophysical properties contribute to cancer in vivo. First, we investigated the melanoma-like phenotype arising from serotonergic signaling by 'instructor' cells-a cell population that is able to induce a metastatic phenotype in normal melanocytes. We show that when these instructor cells are depolarized, blood vessel patterning is disrupted in addition to the metastatic phenotype induced in melanocytes. Surprisingly, very few instructor cells need to be depolarized for the hyperpigmentation phenotype to occur; we present a model of antagonistic signaling by serotonin receptors that explains the unusual all-or-none nature of this effect. In addition to the body-wide depolarization-induced metastatic phenotype, we investigated the bioelectrical properties of tumor-like structures induced by canonical oncogenes and cancer-causing compounds. Exposure to carcinogen 4-nitroquinoline 1-oxide (4NQO) induces localized tumors, but has a broad (and variable) effect on the bioelectric properties of the whole body. Tumors induced by oncogenes show aberrantly high sodium content, representing a non-invasive diagnostic modality. Importantly, depolarized transmembrane potential is not only a marker of cancer but is functionally instructive: susceptibility to oncogene-induced tumorigenesis is significantly reduced by forced prior expression of hyperpolarizing ion channels. Importantly, the same effect can be achieved by pharmacological manipulation of endogenous chloride channels, suggesting a strategy for cancer suppression that does not require gene therapy. Together, these data extend our understanding of the recently demonstrated role of transmembrane potential in tumor formation and metastatic cell behavior. V(mem) is an important non-genetic biophysical aspect of the microenvironment that regulates the balance between normally patterned growth and carcinogenesis.
Utilizing phase for the grouping of PS in urban high-resolution in-SAR-images (2011)

Persistent Scatterer (PS) analysis of high-resolution space-borne SAR images has become an important means for remote sensing in urban regions, since many PS result from building facades. This offers the opportunity to recognize building structures (e.g., number of floors) from such pattern. In this contribution an approach is proposed to group sets of PS according to Gestalt principles. Stacking data from multiple similar orbits not only yields repeatability and enhanced visibility of object features in amplitude data - but also interferometric phases as a clear hint for height above ground. Here we compare Gestalt grouping utilizing this additional attribute against neglecting it. The experiments indicate that the use of such phase clearly helps improving recognition and reducing search effort.
2.5 million cell/inch/sup 2/, low-voltage DMOS FET technology (2002)

Device modeling, device design optimization for specific applications, and future trends in power MOSFET technology are examined. A DMOS FET technology with 2.5 million cells/inch/sup 2/ and submicron channel length that minimizes on-resistance is introduced. By implementing an optimized gate oxide and a submicron channel length, specific-on-resistances of 1.3 to 1.4 m Omega -cm/sup 2/ for a 50 V DMOS FET and 1.5 to 1.65 m Omega -cm/sup 2/ for a 60 V DMOS FET have been achieved. This technology yields low specific on-resistance and ruggedness simultaneously. As shown, a 60 V, 18 m Omega rated part in a TO-220 package sustains 202 A under UIS testing. The 2.5 million cells/inch/sup 2/ DMOS FET technology not only has 40-50% smaller die size, but also lower gate charge for the same on-resistance. The basic process architecture allows the flexibility to fabricate a 30 V DMOS FET with less than 0.9 m Omega -cm/sup 2/ by changing the starting process with low resistivity silicon. These low on-resistances have been achieved in high-volume manufacturing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Helicobacter pylori and peptic ulcers: the present position. (1992)

Helicobacter pylori and peptic ulcers: the present position
Ultrasensitive Electrochemical Immunosensor for Clinical Immunoassay Using Thionine-Doped Magnetic Gold Nanospheres as Labels and Horseradish Peroxidase as Enhancer (2008)

A new signal amplification strategy based on thionine (TH)-doped magnetic gold nanospheres as labels and horseradish peroxidase (HRP) as enhancer holds promise to improve the sensitivity and detection limit of the immunoassay for carcinoembryonic antigen (CEA), as a model protein. This immunoassay system was fabricated on a carbon fiber microelectrode (CFME) covered with a well-ordered anti-CEA/protein A/nanogold architecture. The reverse micelle method was initially used for the preparation of TH-doped magnetic gold nanospheres (nanospheres), and the synthesized nanospheres were then labeled on HRP-bound anti-CEA as a secondary antibody (bionanospheres). Sandwich-type protocol was successfully introduced to develop a new high-efficiency electrochemical immunoassay with the labeled bionanospheres toward the reduction of H2O2. Under optimized conditions, the linear range of the proposed immunoassay without HRP as enhancer was 1.2-125 ng/mL CEA, whereas the assay sensitivity by using HRP as enhancer could be further increased to 0.01 ng/mL with the linear range from 0.01 to 160 ng/mL CEA. The developed immunoassay method showed good precision, high sensitivity, acceptable stability and reproducibility, and could be used for the detection of real samples with consistent results in comparison with those obtained by the enzyme-linked immunosorbent assay (ELISA) method.