gebhart/patrepeval huggingface dataset:
Intake of phytochemicals among Japanese, calculated by the new FFF database (2004)

Effects of phytochemicals on human health are suggested from various animal experiments, but human studies remain insufficient. We have constructed a database of various phytochemicals (polyphenols, carotenoids, and sulphur compounds) (http://www.life-science.jp/fff/) and estimated the amount of intake among Japanese population. The subjects were volunteers (16 males and 63 females, averagely aged 71 and 61, respectively) in Iwate city. Average BMI was 23 in both sexes. Intake of 36 phytochemicals was calculated from one-day dietary records of all intake, by multiplying concentrations of each phytochemical in foods. Phytochemicals with average intake of at least 10 micromole per day were catechin, isoflavones, isothiocyanate, ferulic acid, quercetin, cinnamic acid and chlorogenic acid. Chief component analysis yielded 12 factors (80%).
AN IMPROVED CRYOPRESERVATION PROCEDURE FOR HUMAN FETAL PANCREAS TISSUES (1987)

Improved viability and function of insulin-producing beta (B) cells of frozen-stored human fetal pancreatic tissue was obtained by a two-step method utilizing high concentrations of dimethyl sulfoxide (DMSO). Human fetal pancreata (14-23-week gestation) obtained from pathologic abortions were teased and cultured overnight. Prior to freezing the tissues were immersed in 0.9% saline containing 0.5 M DMSO for 30 min (room temperature) and then placed in 2.1 M DMSO on ice for 5 min. The tissues were frozen by the method previously developed in our laboratory and stored at -196 degrees C. The frozen-stored tissues were subsequently thawed at 24 degrees C and cultured overnight before viability testing. Viability and function of the B cells were assessed by several specific assay methods; glucose plus theophylline-induced insulin release during static incubation and perifusion, 3H-leucine incorporation into insulin, and insulin content of the tissue grown in athymic mice for 7 days. The response to glucose plus theophylline stimulation, measured on the frozen-thawed tissue one day after thawing, was 80% of the level measured in control tissue maintained in organ culture. Frozen-thawed tissues maintained in organ culture for 1 week responded comparably in the in vitro assay systems. The insulin content of frozen-thawed pancreatic tissue removed from athymic mice 1 week after transplantation was approximately 60% of the amount measured in the control grafts. These results demonstrate the utility of our procedure in the maintenance of the viability and function of frozen-stored human B cells both in culture and after transplantation.
Development of Small‐Diameter Vascular Grafts (2007)

This review summarizes the current status of vascular grafts used clinically, updates the most recent developments on vascular tissue engineering, and discusses the challenges for the future.
Micro- and Nanoscale Topographies on Silk Regulate Gene Expression of Human Corneal Epithelial Cells (2017)

Patterned silk film substrates may serve as a scaffold and provide biophysical cues to corneal epithelial cells that change their gene expression, alter cellular adherence, morphology, and may offer a promising customizable material for use in ocular surface repair.
Prediction of anemia on unenhanced computed tomography of the thorax. (2003)

The diagnosis of anemia should be suggested whenever the interventricular septum is visualized on unenhanced CT.
The NACHT, LRR and PYD Domains-Containing protein 3 (NLRP3) Inflammasome Mediates Inflammation and Voiding Dysfunction in a Lipopolysaccharide-Induced Rat Model of Cystitis (2016)

Overall, the results demonstrate the potential importance of inflammasomes in bacterial cystitis as well as the ability of the bladder wall injection technique to isolate the <i>in vivo</i> effects of specific inflammasome ligands to the physiological changes associated with cystitis.
<scp>dd</scp>-Diketopiperazines:  Antibiotics Active against <i>Vibrio </i><i>a</i><i>nguillarum</i> Isolated from Marine Bacteria Associated with Cultures of<i> Pecten </i><i>m</i><i>aximus</i> (2003)

Bacterial strains CF-20 (CECT5719) and C-148 (CECT5718), isolated from cultures of larvae of molluscs, are shown to produce substances 1−5 with strong antibiotic activity against Vibrio anguillarum (MIC: 0.03−0.07 μg/mL) and identified as the dd-diketopiperazines cyclo(d)-Pro-(d)-Phe (1), cyclo(d)-Pro-(d)-Leu (2), cyclo(d)-Pro-(d)-Val (3), cyclo(d)-Pro-(d)-Ile (4), and cyclo-trans-4-OH-(d)-Pro-(d)-Phe (5). Comparison with other stereoisomers indicates that inhibition of V. anguillarum is associated with the presence of at least one d-amino acid in the diketopiperazine system. This is the first time a series of dd-diketopiperazines has been isolated from a single natural source and their inhibitory activity against V. anguillarum described.
Ophthalmic applications of the digital micromirror device (DMD) (2009)

Cataract surgery with IOL implantation is performed on millions of patients every year. Despite 25 years of technological innovation, post-surgical refractive errors have remained a problem. Now these errors can be corrected using Calhoun Vision, Inc's light adjustable lens (LAL). The correction is accomplished by implanting a light-sensitive lens, then illuminating it with a spatially varying irradiance profile during a postoperative treatment. This irradiance profile is provided by a Light Delivery Device (LDD), which projects an image of a Texas Instruments DMD onto the implanted lens. Commercial sales of this system began in the summer of 2008 in Europe; US clinical trials began in January 2009.
A randomized investigator‐blind parallel‐group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne (2014)

AzA15% gel is a safe and effective treatment and maintenance treatment of female adult acne with non-inferior efficacy to AD 0.1% gel in the control of inflammatory acne.
Identification and Genomic Characterization of a New Virus ( <i>Tymoviridae</i> Family) Associated with Citrus Sudden Death Disease (2005)

Citrus sudden death (CSD) is a new disease that has killed approximately 1 million orange trees in Brazil. Here we report the identification of a new virus associated with the disease. RNAs isolated from CSD-affected and nonaffected trees were used to construct cDNA libraries. A set of viral sequences present exclusively in libraries of CSD-affected trees was used to obtain the complete genome sequence of the new virus. Phylogenetic analysis revealed that this virus is a new member of the genus Marafivirus. Antibodies raised against the putative viral coat proteins allowed detection of viral antigens of expected sizes in affected plants. Electron microscopy of purified virus confirmed the presence of typical isometric Marafivirus particles. The screening of 773 affected and nonaffected citrus trees for the presence of the virus showed a 99.7% correlation between disease symptoms and the presence of the virus. We also detected the virus in aphids feeding on affected trees. These results suggest that this virus is likely to be the causative agent of CSD. The virus was named Citrus sudden death-associated virus.
Dynamic feedback controller of Euler angles and wind parameters estimation for a quadrotor unmanned aerial vehicle (2004)

A nonlinear dynamic model for a quadrotor unmanned aerial vehicle is presented with a new vision of state parameter control which is based on Euler angles and open loop positions state observer. This method emphasizes on the control of roll, pitch and yaw angle rather than the translational motions of the UAV. For this reason the system has been presented into two cascade partial parts, the first one relates the rotational motion whose the control law is applied in a closed loop form and the other one reflects the translational motion. A dynamic feedback controller is developed to transform the closed loop part of the system into linear, controllable and decoupled subsystem. The wind parameters estimation of the quadrotor is used to avoid more sensors. Hence an estimator of resulting aerodynamic moments via Lyapunov function is developed. Performance and robustness of the proposed controller are tested in simulation.
Advances in optical fiber amplifiers for WDM systems (1999)

Broadband optical amplifiers are key elements and enablers for WDM systems. New amplifier technologies for extending gain-bandwidth and equalizing the power deviation among WDM signals are discussed toward the next generation of ultra-high-capacity dense WDM systems.
A study of support vectors on model independent example selection (1999)

As databases for real-world problems increase in size, there is a need in many situations to select and keep relevant training data for efficient storage and processing reasons. Support vector machines (SVMs) reportedly exhibit certain desirable properties in selecting and preserving useful training data as support vectors.
HF and DF lasers by direct electrical discharge excitation (1973)

Using a high-current long-pulse electron-beam-stabilized electrical discharge, laser oscillation has been observed on several vibration-rotation bands of HF and DF in mixtures containing less than 1% HF or DF. Results in HF/argon mixtures with 10% added N2, H2, or D2 established that HF is vibrationally pumped by direct electron impact and also by vibrational energy transfer from H2. Rotational nonequilibrium as well as cascade coupling between 3 → 2 lines and 2 → 1 lines were inferred from the time sequence of the laser emission.
The interaction between mushroom strains and fungicides in the control of dry bubble disease caused by <i>Verticilliumfungicola</i> (1978)

SUMMARY Five fungicides were compared for control of Verticilliumfungicola on six strains of the cultivated mushroom. The strains showed considerable differences both in their sensitivity to the fungicides and their susceptibility to infection. These factors complicated comparison of the fungicides, but benodanil was less effective than chlorothalonil against V. fungicola.
Intracellular single-chain antibody against hepatitis B virus core protein inhibits the replication of hepatitis B virus in cultured cells (1999)

Hepatitis B virus (HBV) is one of the major causes of chronic liver diseases and hepatocellular carcinoma. In this study, we used a single chain antibody (sFv), which is a man-made antibody with a strong affinity of immunoglobulin, to inhibit HBV replication. Because HBV replication can only take place in the viral nucleocapsid made of HBV core protein (HBc), we generated anti-HBc sFv and examined whether intracellular anti-HBc sFv could inhibit viral replication in the human hepatoblastoma-derived cell line that produces HBV (HB611). With respect to HBV replication intermediates, both single-stranded and partially double-stranded DNA intermediates were markedly suppressed in the cells expressing anti-HBc sFv, although HBV RNA intermediates were not affected. This suggested that intracellular anti-HBc sFv inhibited HBV DNA replication by inhibiting reverse transcription from HBV pregenome RNA to single-stranded DNA. Because the sFv-HBc complex was detected in the cells expressing anti-HBc sFv by immunoprecipitation analysis but the quantity of intracellular HBc was not affected, the anti-HBc sFv was suggested to inhibit HBV DNA replication by interfering with the function of HBc. These results indicate that intracellular sFv against HBc might be effective as a novel active molecule for gene therapy of hepatitis B.
How risk management can prevent future wildfire disasters in the wildland-urban interface (2013)

Recent fire seasons in the western United States are some of the most damaging and costly on record. Wildfires in the wildland-urban interface on the Colorado Front Range, resulting in thousands of homes burned and civilian fatalities, although devastating, are not without historical reference. These fires are consistent with the characteristics of large, damaging, interface fires that threaten communities across much of the western United States. Wildfires are inevitable, but the destruction of homes, ecosystems, and lives is not. We propose the principles of risk analysis to provide land management agencies, first responders, and affected communities who face the inevitability of wildfires the ability to reduce the potential for loss. Overcoming perceptions of wildland-urban interface fire disasters as a wildfire control problem rather than a home ignition problem, determined by home ignition conditions, will reduce home loss.
Kinetics of a Model Nucleoside (Guanosine) Release from Biodegradable Poly(<scp>dl</scp>-lactide-<i>co</i>-glycolide) Microspheres: A Delivery System for Long-Term Intraocular Delivery (2000)

The objective of this study was to prepare poly(DL-lactide-co-glycolide) (PLGA) microspheres containing guanosine as a model drug for intraocular administration. Microspheres were prepared by solvent evaporation technique using o/w emulsion system. The influence of composition and molecular weight of PLGA, drug loading efficiency, microsphere size, and in vitro and in vivo release rates were determined. Differential scanning calorimetry (DSC) and FTIR studies were conducted to examine the guanosine-polymer interaction. In vitro release studies indicated that the permeant release from microspheres exhibits an initial burst followed by slow first-order kinetics. Ascending molecular weights of the polymers generated progressively slower release rates. Three different sizes of microspheres were prepared. The release continued for 7 days with a maximum of 70% of the content released within that time period. DSC and FTIR studies showed no polymer-guanosine interaction. A novel microdialysis technique was used to examine the initial release kinetics from microspheres in isolated vitreous humor. This technique was also employed to observe in vivo intravitreal release in albino rabbits. A good correlation exists between in vitro and in vivo release rates from both 75 and 140 kDa PLGA microspheres. Guanosine-loaded microspheres could be prepared for once-a-week intravitreal injection with minimum required concentration maintained throughout the dosing interval. Because the structural and solubility characteristics of guanosine are similar to those of acyclovir and ganciclovir (two acycloguanosine analogues effective against herpes simplex virus [HSV-1] and cytomegalovirus [CMV], respectively), similar biodegradable polymer-based microsphere technology can be employed for the long-term intraocular delivery of these two drugs.
Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. (1985)

Using polysomal immunoselected rat liver glutathione S-transferase mRNAs, we have constructed cDNA clones using DNA polymerase I, RNase H, and Escherichia coli ligase (NAD+)-mediated second strand cDNA synthesis as described by Gubler and Hoffman (Gubler, U., and Hoffman, B. S. (1983) Gene 25, 263-269). Recombinant clone, pGTB42, contained a cDNA insert of 900 base pairs whose 3' end showed specificity for the Yc mRNA in hybrid-select translation experiments. The nucleotide sequence of pGTB42 has been determined, and the complete amino acid sequence of a Yc subunit has been deduced. The cDNA clone contains an open reading frame of 663 nucleotides encoding a polypeptide comprising 221 amino acids with a molecular weight of 25,322. The NH2-terminal sequence deduced from pGTB42 is in agreement with the first 39 amino acids determined for a Ya-Yc heterodimer by conventional protein-sequencing techniques. A comparison of the nucleotide sequence of pGTB42 with the sequence of a Ya clone, pGTB38, described previously by our laboratory (Pickett, C. B., Telakowski-Hopkins, C. A., Ding, G. J.-F., Argenbright, L., and Lu, A.Y.H. (1984) J. Biol. Chem. 259, 5182-5188) reveals a sequence homology of 66% over the same regions of both clones; however, the 5'- and 3'-untranslated regions of the Ya and Yc mRNAs are totally divergent in their sequences. The overall amino acid sequence homology between the Ya and Yc subunits is 68%, however, the NH2-terminal domain is more highly conserved than the middle or carboxyl-terminal domains. Our data suggest that the Ya and Yc subunits of the rat liver glutathione S-transferases are products of two different mRNAs which are derived from two related yet different genes.
NK Cell Activation by Dendritic Cells Is Dependent on LFA-1-Mediated Induction of Calcium-Calmodulin Kinase II: Inhibition by HIV-1 Tat C-Terminal Domain (2002)

Abstract In this study, we show that binding to autologous dendritic cells (DC) induces a calcium influx in NK cells, followed by activation of the calcium-calmodulin kinase II (CAMKII), release of perforin and granzymes, and IFN-γ secretion. CAMKII is induced via LFA-1: indeed, oligomerization of LFA-1 leads to CAMKII induction in NK cells. Moreover, release of lytic enzymes and cytotoxic activity is strongly reduced by masking LFA-1 or by adding CAMKII inhibitors such as KN62 and KN93, at variance with the inactive compound KN92. NK cell-mediated lysis of DC and IFN-γ release by NK cells upon NK/DC contact are inhibited by exogenous HIV-1 Tat: the protein blocks calcium influx and impairs CAMKII activation elicited via LFA-1 in NK cells, eventually inhibiting degranulation. Experiments performed with synthetic, overlapping Tat-derived peptides showed that the C-terminal domain of the protein is responsible for inhibition. Finally, both KN62 and Tat reduced the extension of NK/DC contacts, possibly affecting NK cell granule polarization toward the target. These data provide evidence that exogenous Tat inhibits NK cell activation occurring upon contact with DC: this mechanism might contribute to the impairment of natural immunity in HIV-1 infection.
NAF‐1 antagonizes starvation‐induced autophagy through AMPK signaling pathway in cardiomyocytes (2015)

NAF-1 (nutrient-deprivation autophagy factor-1), an autophagy-related gene-related (ATG) protein, has been implicated in the autophagic pro-survival response. However, its role in autophagy has not been examined in the cardiomyocytes. In this study, we found that nutritional stress (NS) induced by glucose deprivation strongly induced autophagy in cultured neonatal rat cardiomyocytes, which was associated with NAF-1 down-regulation in cardiomyocytes under NS conditions. Furthermore, we demonstrate that ectopic expression of NAF-1 was sufficient to inhibit autophagy in cardiomyocytes under glucose deprivation conditions. Moreover, results of the co-immunoprecipitation assay indicate that NAF-1 antagonized autophagy by promoting the interaction between Beclin1 and Bcl-2 in NS-induced cardiomyocytes. Importantly, our results indicate that overexpression of NAF-1 significantly inhibited AMPK activity and protected cardiomyocytes from NS-induced cell death. Taken together, these data show that ectopic expression of NAF-1 antagonizes the degree of autophagy in cardiomyocytes and enhances cell survival during starvation conditions.
Single-lobed emission from phase-locked array lasers (1986)

Phased-array lasers which emit in a single far-field lobe corresponding to the lowest-order mode are described. Single-lobed diffraction-limited operations are achieved by two simple approaches: (i) close-coupled elements and (ii) diffraction-coupled arrays.
Examining Effects of Advertising Campaign Publicity in a Field Study (2006)

<h3>ABSTRACT</h3> Previous experimental research found that the pre-exposure of publicity about advertisements has two distinct but related effects in advertised brand recall: (a) a facilitative effect on publicized brands and (b) an inhibitive effect on nonpublicized brands. We speculate that publicity effects exist beyond the controlled experiments. In this article, we used a field study to investigate the effects of publicity messages related to the commercials aired during three Super Bowl games. We found that publicity had a positive impact on the memory of subsequent advertisements for both recall and recognition, but publicity effects were more evident in recall than in recognition.
Ligand protonation and rates of ligation with nickel(II) (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLigand protonation and rates of ligation with nickel(II)James C. Cassatt, William A. Johnson, Lloyd M. Smith, and Ralph G. WilkinsCite this: J. Am. Chem. Soc. 1972, 94, 24, 8399–8406Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/ja00779a019https://doi.org/10.1021/ja00779a019research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Optimal decomposition for quad-trees with leaf dependencies</title> (1997)

We propose a fast and efficient algorithm which finds the optimal quad-tree (QT) decomposition with leaf dependencies in the rate distortion sense. The underlying problem is the encoding of an image by a variable block size scheme, where the block size in encoded using a QT, each block is encoded by one of the admissible quantizers and the quantizers are transmitted using a first order differential pulse code modulation (DPCM) scheme along the scanning path. First we define an optimal scanning path for a QT such that successive blocks are always neighboring blocks. Then we propose a procedure which infers such an optimal path from the QT-decomposition and introduce a special optimal path which is based on a Hilbert curve. Then we consider the case where the image is losslessly encoded using a QT- decomposition and the optimal quantizer selection. We then apply the Lagrangian multiplier method to solve the lossy case, and show that the unconstrained problem of the Lagrangian multiplier method can be solved using the algorithm introduced for the lossless case. Finally we present a mean value QT-decomposition example, where the mean values are DPCM encoded.
Development of High-capacity Metal Hydride Electrodes using Various Rare Earth-Mg-Ni Based Super-lattice Alloys (2006)

Abstract not Available.
A family of statistical symmetric divergences based on Jensen's inequality (2010)

We introduce a novel parametric family of symmetric information-theoretic distances based on Jensen's inequality for a convex functional generator. In particular, this family unifies the celebrated Jeffreys divergence with the Jensen-Shannon divergence when the Shannon entropy generator is chosen. We then design a generic algorithm to compute the unique centroid defined as the minimum average divergence. This yields a smooth family of centroids linking the Jeffreys to the Jensen-Shannon centroid. Finally, we report on our experimental results.