gebhart/patrepeval huggingface dataset:
Modulation of leukocyte genetic expression by novel purine nucleoside analogs. A new approach to antitumor and antiviral agents (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModulation of leukocyte genetic expression by novel purine nucleoside analogs. A new approach to antitumor and antiviral agentsPierre A. Bonnet and Roland K. RobinsCite this: J. Med. Chem. 1993, 36, 6, 635–653Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://doi.org/10.1021/jm00058a001RIGHTS & PERMISSIONSArticle Views247Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
A Systematic Literature Review with Meta-Analyses of Within- and Between-Day Differences in Objectively Measured Physical Activity in School-Aged Children (2014)

School-aged children are more active on weekdays than weekend days. The outcome measure influences the conclusions for other comparisons. Findings support the tailoring of intervention strategies to specific time periods.
Identification of 19 New Metabolites Induced by Abnormal Amino Acid Conjugation in Isovaleric Acidemia (2005)

analysis (Fig.
Articular cartilage repair using a resorbable matrix scaffold. (2008)

The creation of cartilage repair tissue relies on the implantation or neosynthesis of cartilage matrix elements. One cartilage repair strategy involves the implantation of bioabsorbable matrices that immediately fill a chondral or osteochondral defect. Such matrices support the local migration of chondrogenic or osteogenic cells that ultimately synthesize new ground substance. One such matrix scaffold, a synthetic resorbable biphasic implant (TruFit Plug; Smith & Nephew, San Antonio, TX), is a promising device for the treatment of osteochondral voids. The implant is intended to serve as a scaffold for native marrow elements and matrix ingrowth in chondral defect repair. The device is a resorbable tissue regeneration scaffold made predominantly from polylactide-coglycolide copolymer, calcium sulfate, and polyglycolide. It is approved in Europe for the treatment of acute focal articular cartilage or osteochondral defects but is approved by the US Food and Drug Administration only for backfill of osteochondral autograft sites. Preclinical studies demonstrated restoration of hyaline-like cartilage in a goat model with subchondral bony incorporation at 12 months. Early clinical results of patients enrolled in the Hospital for Special Surgery Cartilage Registry have been favorable, with a good safety profile.
Moving Obstacle Avoidance Using a LRF Sensor (2006)

In this paper, an obstacle avoidance algorithm using a laser range finder (LRF) sensor for a mobile manipulator is investigated. A moving obstacle is regarded as a moving circle and therefore the obstacle detection problem becomes the problem of finding the center of a moving circle and its radius. To estimate the position and velocity of the obstacle, Kalman filter is designed. Using velocity and angular velocity of obstacle, we consider that the obstacle move straight. So we forecast a collision of robot and obstacle. Experimental results are provided
Multidimensional counting grids: Inferring word order from disordered bags of words (2012)

Models of bags of words typically assume topic mixing so that the words in a single bag come from a limited number of topics. We show here that many sets of bag of words exhibit a very different pattern of variation than the patterns that are efficiently captured by topic mixing. In many cases, from one bag of words to the next, the words disappear and new ones appear as if the theme slowly and smoothly shifted across documents (providing that the documents are somehow ordered). Examples of latent structure that describe such ordering are easily imagined. For example, the advancement of the date of the news stories is reflected in a smooth change over the theme of the day as certain evolving news stories fall out of favor and new events create new stories. Overlaps among the stories of consecutive days can be modeled by using windows over linearly arranged tight distributions over words. We show here that such strategy can be extended to multiple dimensions and cases where the ordering of data is not readily obvious. We demonstrate that this way of modeling covariation in word occurrences outperforms standard topic models in classification and prediction tasks in applications in biology, text modeling and computer vision.
Toward high definition television (1988)

The authors show how the transmission/display standards can be expected to evolve for satellite broadcasting based on the MAC standard. Furthermore, the possibilities for evolution of the studio standard through to an HDTV standard of 1250/50/2:1 or 1250/50/1:1 are considered. Such evolution of both studio and display standards is made possible by the combination of the MAC system for use in satellite broadcasting and by the use of studio standards, including the HDTV standard which are based on 50 Hz field rate and the world wide digital studio standard of CCIR Recommendation 601.
A Geometric Understanding of Deep Learning (2020)

This work introduces an optimal transportation (OT) view of generative adversarial networks (GANs). Natural datasets have intrinsic patterns, which can be summarized as the manifold distribution principle: the distribution of a class of data is close to a low-dimensional manifold. GANs mainly accomplish two tasks: manifold learning and probability distribution transformation. The latter can be carried out using the classical OT method. From the OT perspective, the generator computes the OT map, while the discriminator computes the Wasserstein distance between the generated data distribution and the real data distribution; both can be reduced to a convex geometric optimization process. Furthermore, OT theory discovers the intrinsic collaborative—instead of competitive—relation between the generator and the discriminator, and the fundamental reason for mode collapse. We also propose a novel generative model, which uses an autoencoder (AE) for manifold learning and OT map for probability distribution transformation. This AE–OT model improves the theoretical rigor and transparency, as well as the computational stability and efficiency; in particular, it eliminates the mode collapse. The experimental results validate our hypothesis, and demonstrate the advantages of our proposed model.
Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus (2016)

Fasting plasma concentrations of the proatherogenic gut microbe-generated metabolite TMAO are higher in diabetic patients and portend higher major adverse cardiac events and mortality risks independent of traditional risk factors, renal function, and relationship to glycemic control.
Analysis of the promotors of the single‐copy genes for plastocyanin and subunit δ of the chloroplast ATP synthase from spinach (1990)

The promotors of the single-copy genes for subunit delta of the chloroplast ATP synthase (atpD) and plastocyanin (PC) from spinach have been sequenced, dissected and analysed in transgenic F0 and F1 tobacco plants using the bacterial GUS gene as a reporter for promotor activity. The transcription of these genes is photo-controlled. The results have been compared with those obtained for the spinach rbcS-1 gene, one of the light-regulated genes encoding the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase, and for the cauliflower mosaic virus (CaMV) 35S RNA promotor. We find that the 5' upstream regions of about 1200 nucleotides contain all the sequences required for light regulation, organ-, tissue- and development-specific expression, and that they are structurally diverse. Their cis-acting elements are functionally defined. The proximal regions of the spinach promotors contain potential TATA, CAAT and T-cyt boxes at appropriate positions, but only sequence elements with low similarity to published light-responsive elements. Positive light-stimulated regions, regions with constitutive, light-independent enhancing effects and with 'silencer'-like activity in complete darkness are found in proximal and far upstream promotor segments. Highest activity of these promotors is correlated with the presence of chloroplasts but is not confined to photosynthetic tissue. Surprisingly, expression is observed in the phloem regions of transgenic leaves, leaf and floral stems, in the vascular area of anthers and in pollen. No histochemical staining has been detected in roots. The distal region of atpD located between -1137 and -590 contains elements for expression in the outer phloem, the region from -590 to -185 for activity in the inner phloem of floral stems. Similar tissue-specific patterns are observed with a fusion between the caufliflower mosaic virus 35S RNA promotor and the GUS gene.
Articulate: a conversational interface for visual analytics (2009)

While many visualization tools exist that offer sophisticated functions for charting complex data, they still expect users to possess a high degree of expertise in wielding the tools to create an effective visualization. This poster presents Articulate, an attempt at a semi-automated visual analytic model that is guided by a conversational user interface. The goal is to relieve the user of the physical burden of having to directly craft a visualization through the manipulation of a complex user-interface, by instead being able to verbally articulate what the user wants to see, and then using natural language processing and heuristics to semi-automatically create a suitable visualization.
The effect of microstructure on the height of potential energy barriers in porous tin dioxide gas sensors (1988)

A theoretical study is made on the height of potential energy barriers formed at intergranular contacts in porous tin dioxide. Expressions are derived for the height of barriers in a one-dimensional case when the donor concentration is constant and also when there is a concentration gradient in the surface. Expressions are also derived for the case when the intergranular contact is in the shape of a cylinder. The treatment in this case, together with the application of Fermi–Dirac statistics, leads to a conclusion of the existence of a distribution of the height of barriers. The potential barrier on the center line of the cylinder vanishes above a critical radius. The effect of the distribution of the height of barriers on the activation energy of the conductance of porous tin dioxide is discussed on the basis of a random barrier network model.
A low-power and low-complexity DCT/IDCT VLSI architecture based on backward Chebyshev recursion (2002)

A low-power parallel VLSI structure for DCT/IDCT is proposed. By treating the transformations as the evaluation of the Chebyshev series, and exploiting the Backward Chebyshev Recursion (BCR), we can reduce the total number of multipliers (N+1 for IDCT, 2N-2 for DCT). The property of BCR is also used to compute the DCT/IDCT through the down-sampled even and odd sequences. Since the operation frequency for the down-sampled sequences is two times slower, the speed penalty caused by the low-voltage design can be compensated at the architectural level. The total multipliers required for the low-power design is only 2N+1 for IDCT and 3N-3 for DCT. Extension to downsampling-by-4 is also achievable at a reasonable increase in hardware complexity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
FPGA modeling of diverse superscalar processors (2012)

There is increasing interest in using Field Programmable Gate Arrays (FPGAs) as platforms for computer architecture simulation. This paper is concerned with modeling superscalar processors with FPGAs. To be transformative, the FPGA modeling framework should meet three criteria. (1) Configurable: The framework should be able to model diverse superscalar processors, like a software model. In particular, it should be possible to vary superscalar parameters such as fetch, issue, and retire widths, depths of pipeline stages, queue sizes, etc. (2) Automatic: The framework should be able to automatically and efficiently map any one of its superscalar processor configurations to the FPGA. (3) Realistic: The framework should model a modern superscalar microarchitecture in detail, ideally with prototype quality, to enable a new era and depth of microarchitecture research. A framework that meets these three criteria will enjoy the convenience of a software model, the speed of an FPGA model, and the experience of a prototype. This paper describes FPGA-Sim, a configurable, automatically FPGA-synthesizable, and register-transfer-level (RTL) model of an out-of-order superscalar processor. FPGA-Sim enables FPGA modeling of diverse superscalar processors out-of-the-box. Moreover, its direct RTL implementation yields the fidelity of a hardware prototype.
Elemental Analysis in Astragali Radix by Using ICP-AES and Determination of the Original Agricultural Place of Oriental Medicine by Using a Chemometrics (2001)

We have investigated the trace amount in an oriental medicine in oder to determine the geographical origin by using inductively coupled plasma-atomic emission spectrometry(ICP-AES) and chemometric anlysis with principal component analysis(PCA) and pattern recognition. Astragali Radix from several agricultural places in Korea was selected as an example of the oriental medicine and analyzed by ICP-AES. The dried Astragali Radix sample was treated with and , then digested using microwave oven. Elements such as Mg, Al, K, Ca, Ti, Mn, Fe, Cu, Zn, and Ba with different concentrations were found an used for the identification of the origin of agriculture places. Especially, the concentration of Al, Fe, Zn and Ti were employed to investigate the relationship between. Astragali Radix and the agricultural places by PCA and pattern recognition. We have made a program that is based on chemometrics in analytical spectroscopy. The results of the chemometrics analysis indicated that a distinction among Yechon and Chechon, Chungson, Kurye and Chinese Astragali Radix could be made. We believe that principal component analysis(PCA) and pattern recognition is a valuable tool to identify the origin of Astragali Radix in terms of the agricultural place.
Melt processing for obtaining REBa/sub 2/Cu/sub 3/O/sub y/ superconductors (RE=Nd, Sm) with high T/sub c/ and large J/sub c/ (1995)

An oxygen-controlled melt growth (OCMG) process has been employed for NdBa/sub 2/Cu/sub 3/O/sub y/ (Nd123) and SmBa/sub 2/Cu/sub 3/O/sub y/ (Sm123) superconductors for a comparative study. Both Nd123 and Sm123 samples melt-grown in reduced oxygen atmospheres exhibited an enhanced superconducting transition temperature (T/sub c/) with a sharp transition and large critical current density (J/sub c/) in a high field region at 77 K and for the applied field parallel to the c-axis of samples (H/c). For Nd123, a preferential formation of high T/sub c/ phase in a low oxygen partial pressure (P(O/sub 2/)) could be qualitatively described considering the thermodynamic stability boundaries of the Nd/sub 1+x/Ba/sub 2-x/Cu/sub 3/O/sub y/ solid solutions on the LOG[P(O/sub 2/)] vs. 1/T (K/sup 9/-1) phase diagram. A long-term oxygen annealing study for an OCMG-processed Nd123 sample revealed that the annealing temperature should be as low as 300/spl deg/C.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Blind Interference Canceling Technique for Two-Stage Harmonic Rejection in Down-mixers (2008)

Abstract—This paper presents practical experiments on a harmonic rejection down-mixer, which offers up to 75 dB of harmonic rejection, without an RF filter. The down-mixer uses a two-stage approach; the first stage is an analog multi-path/multi-phase harmonic rejection mixer followed by a second stage providing additional harmonic rejection based on blind adaptive interference canceling in the discrete-time domain. The aim is to show its functional operation. The canceler cannot cope with DC offsets. The DC offsets are removed by highpass filters. The signal paths used to obtain an estimate of the interference must be designed to provide as much attenuation of the desired signal as possible. Front-end nonlinearities and DC offsets are discussed. I.
1, 3-Oxazines and Related Compounds. XIV. Facile Synthesis of 2, 3, 6-Trisubstituted 2, 3-Dihydro-1, 3-oxazine-5-carboxylic Acids and 1, 4-Disubstituted 3-Acyl-β-lactams from Acyl Meldrum's Acids and Schiff Bases (1987)

Simple preparations of 2, 3, 6-trisubstituted 2, 3-dihydro-1, 3-oxazine-5-carboxylic acids (4) and 1, 4-disubstituted 3-acyl-β-lactams (5) from acyl Meldrum's acids and Schiff bases were carried out. 2, 3-Disubstituted 5-acy1-3, 4, 5, 6-tetrahydro-2H-1, 3-oxazine-4, 6-diones (3) were isomerized to 4 in a chlorotrimethylsilane?triethylamine system and to 5 by hydrogen chloride.
Diaminozucker, VIII. Über die 6‐Amino‐6‐desoxy‐<scp>L</scp>‐idose (1968)

Abstract Versuche zur Darstellung des 6‐Amino‐6‐desoxy‐ L ‐idopyranose‐hydrochlorids ( 11 ) aus 5 zeigten, daß dieser Zucker auch in kristallinem Zustand instabil ist und nicht rein isoliert werden kann. Die freie Base cyclisiert sofort unter Bildung der 1.6‐Iminoverbindung 8 . Ein neuer Syntheseversuch konnte nicht über das Oxazolin 20 , hinausgeführt werden.
Hemodynamic analysis of virtual stent design for atherosclerotic carotid artery (2011)

We propose a technique to reverse engineer a normal carotid bifurcation from an abnormal artery model based on B-Spline interpolation. This enables us to assess the blood flow pattern in a patient-specific artery for the stenosed and virtually stented conditions. This technique may be applied to understand the cardiovascular condition and to develop a stent to eliminate stenosis and flow resistance. Furthermore, we hypothesise that velocity, wall shear stress and pressure gradient are the key hemodynamics parameters for determining stent performance in terms of improved cardiovascular flow. We show that stenting are able to improve the diseased artery condition from the hemodynamics perspective.
<title>Architecture of a high-performance PACS based on a shared file system</title> (1992)

The Picture Archive and Communication System developed by Loral Western Development Laboratories and Siemens Gammasonics Incorporated utilizes an advanced, high speed, fault tolerant image file server or Working Storage Unit (WSU) combined with 100 Mbit per second fiber optic data links. This central shared file server is capable of supporting the needs of more than one hundred workstations and acquisition devices at interactive rates. If additional performance is required, additional working storage units may be configured in a hyper-star topology. Specialized processing and display hardware is used to enhance Apple Macintosh personal computers to provide a family of low cost, easy to use, yet extremely powerful medical image workstations. The Siemens LiteboxTM application software provides a consistent look and feel to the user interface of all workstation in the family. Modern database and wide area communications technologies combine to support not only large hospital PACS but also outlying clinics and smaller facilities. Basic RIS functionality is integrated into the PACS database for convenience and data integrity.
Novel PEG-organized biocompatible fluorescent nanoparticles doped with an ytterbium cyanoporphyrazine complex for biophotonic applications (2010)

The preparation and properties are described of two types of novel PEG-organized nanoparticles including silica-modified uniform disk-shaped nanoparticles doped with a fluorescent ytterbium cyanoporphyrazine complex; a large enhancement of red emission for both types of nanoparticles is observed in physiological liquids owing to their binding to biomolecules.
Impact of JIT/JVM optimizations on JAVA application performance (2003)

With the promise of machine independence and efficient portability, JAVA has gained widespread popularity in the industry. Along with this promise comes the need for designing an efficient runtime environment that can provide high-end performance for JAVA-based applications. In other words, the performance of JAVA applications depends heavily on the design and optimization of the JAVA Virtual Machine (JVM). In this paper, we start by evaluating the performance of a JAVA server application (SPECjbb2000/spl trade/) on an Intel platform running a rudimentary JVM. We present a measurement-based methodology for identifying areas of potential improvement and subsequently evaluating the effect of JVM optimizations and other platform optimizations. The compiler optimizations presented and discussed in this paper include peephole optimizations and JAVA specific optimizations. In addition, we also study the effect of optimizing the garbage collection mechanism and the effect of improved locking strategies. The identification and analysis of these optimizations are guided by the detailed knowledge of the microarchitecture and the use of performance measurement and profiling tools (EMON and VTune) on Intel platforms.
Behavior of neuro‐epithelial cells during closure of the neural tube (1966)

Abstract Chick embryos ranging in age from 18 to 32 hours were treated with thymidine‐H 3 to examine the cell cycle and nuclear migration of the neuro‐epithelial cells during closure of the neural tube. By plotting the percentage of labeled metaphases against the tune of thymidine‐H 3 application, the DNA‐synthetic period was found to last five hours, the postduplication (G 2 ) stage and prophase two and one‐half hours and the preduplication (G 1 ) stage to be brief or non‐existent. The total cell cycle time was calculated to be eight hours. During DNA synthesis the nuclei are located near the basement membrane; subsequently they migrate to the lumen to undergo mitosis, after which they return to the outer zone to start DNA synthesis for the next cell division. To determine the life span of the neuro‐epithelial cells by a different method, chick embryos were treated with vincristine, a drug known to arrest the mitosis in the metaphase. Fifteen, 26, 34 and 41% of the neuro‐epithelial cells were arrested in the metaphase, one, two, three and four hours after treatment, respectively. Since the “mitotic index” of the neuro‐epithelial cells was 5.2, the duration of the mitosis was calculated to last 25 minutes, and the life span of the neuro‐epithelial cell to be eight hours. Immediately after closure of the neural tube, a different cell type characterized by a round nucleus, pale nucleoplasm and a dark‐staining nucleolus appeared at the periphery of the tube near the basement membrane. These cells, which originate by division from the neuro‐epithelial cells at the lumen, did not incorporate thymidine‐H 3 at any time during further development. They are considered to be primitive neuroblasts and to form the first representatives of the mantle layer.