gebhart/patrepeval huggingface dataset:
Quantitative Outcome Measures of Cartilage Repair in Patients Treated by Tissue Engineering (2005)

Reliable and reproducible outcome measures are essential to assess the efficacy of competing and novel tissue-engineering techniques. The aim of this study was to compare traditional histological analyses with newly developed quantitative biochemical outcome measures for the repair of articular cartilage. The production of a new anti-peptide antibody and the development and validation of a novel method for the extraction and immunoassay of type I collagen are described. The assay was used, in conjunction with existing assays for type II collagen and proteoglycans, to measure levels of the matrix components in repair tissue biopsies obtained from patients treated with the new tissue-engineering therapy Hyalograft C. Frozen sections cut from the same biopsies were stained for proteoglycans, using safranin O, and immunohistochemical analysis was used to assess type I and II collagen staining. Although there was general agreement between the extent of staining and the amounts of the three matrix components, there was a large degree of overlap in biochemical content between biopsies classified histologically on the basis of low, moderate, or abundant staining. The results demonstrate that histological grading of matrix protein abundance to classify repair cartilage as hyaline or fibrocartilagenous is often misleading. In addition, we demonstrate for the first time the ability to measure collagen cross-links in repair tissue biopsies and show that it can be used as a surrogate marker for tissue maturity. Our new range of biochemical techniques provides a standardized method to assess the quality of both engineered cartilage produced in vitro and repair tissue biopsies obtained after in vivo implantation.
Partial interferon-gamma receptor 1 deficiency in a child with tuberculoid bacillus Calmette-Guérin infection and a sibling with clinical tuberculosis. (1997)

Complete interferon-gamma receptor 1 (IFNgammaR1) deficiency has been identified previously as a cause of fatal bacillus Calmette-Guérin (BCG) infection with lepromatoid granulomas, and of disseminated nontuberculous mycobacterial (NTM) infection in children who had not been inoculated with BCG. We report here a kindred with partial IFNgammaR1 deficiency: one child afflicted by disseminated BCG infection with tuberculoid granulomas, and a sibling, who had not been inoculated previously with BCG, with clinical tuberculosis. Both responded to antimicrobials and are currently well without prophylactic therapy. Impaired response to IFN-gamma was documented in B cells by signal transducer and activator of transcription 1 nuclear translocation, in fibroblasts by cell surface HLA class II induction, and in monocytes by cell surface CD64 induction and TNF-alpha secretion. Whereas cells from healthy children responded to even low IFN-gamma concentrations (10 IU/ml), and cells from a child with complete IFNgammaR1 deficiency did not respond to even high IFN-gamma concentrations (10,000 IU/ml), cells from the two siblings did not respond to low or intermediate concentrations, yet responded to high IFN-gamma concentrations. A homozygous missense IFNgR1 mutation was identified, and its pathogenic role was ascertained by molecular complementation. Thus, whereas complete IFNgammaR1 deficiency in previously identified kindreds caused fatal lepromatoid BCG infection and disseminated NTM infection, partial IFNgammaR1 deficiency in this kindred caused curable tuberculoid BCG infection and clinical tuberculosis.
Simulation of mutual coupling effect in circular arrays for direction-finding applications (2000)

The effect of mutual coupling on direction finding in circular arrays is simulated using rigorous electromagnetic computation and the MUSIC superresolution algorithm. The various scenarios studied include element spacing, noise level, antenna gain and delay, and platform effects. Our results show quantitatively the effect of mutual coupling on the direction-of-arrival estimates. The compensation of the coupling effect using the coupling matrix approach is also examined. This approach is found to be quite satisfactory in most cases, except when the array calibration data contain a high noise level or when strong platform effects are present. © 2000 John Wiley & Sons, Inc. Microwave Opt Technol Lett 26: 331–336, 2000.
A design for testability technique for RTL circuits using control/data flow extraction (1996)

In this paper, we present a technique for extracting functional (control/data flow) information from register transfer level (RTL) controller/data path circuits and illustrate its use in design for hierarchical testability of these circuits. This testing procedure and design for testability (DFT) technique is general enough to handle RTL control flow intensive circuits like protocol handlers as well as data flow intensive circuits like digital filters. It makes the combined controller-data path highly testable and does not require any external behavioral information. This scheme has the advantages of low area/delay/power overheads (average of 3.2%, 0.9% and 4.1%, respectively, for benchmarks), high fault coverage (over 99% for most cases), very low test generation times (because it is independent of bit-width), and the advantage of at-speed testing. Experiments show a 2-to-4 (1-to-3) orders of magnitude test generation time advantage over an efficient gate-level sequential test generator (combinational test generator that assumes full scan).
Multifragment Alleles in DNA Fingerprints of the Parrot, Amazona ventralis (1991)

Human DNA probes that identify variable numbers of tandem repeat loci are being used to generate DNA fingerprints in many animal and plant species. In most species the majority of the sc rable autoradiographic bands of the DNA fingerprint represent alleles from numerous unlinked loci. This study was initiated to use DNA fingerprints to determine the amount of band-sharing among captive Hispaniolan parrots (Amazona ventralis) with known genetic relationships. This would form the data base to examine DNA fingerprints of the closely related and endangered Puerto Rican parrot (A. vittata) and to estimate the degree of inbreeding in the relic population. We found by segregation analysis of the bands scored in the DNA fingerprints of the Hispaniolan parrots that there may be as few as two to five loci identified by the human 33.15 probe. Furthermore, at one locus we identified seven alleles, one of which is represented by as many as 19 cosegregating bands. It is unknown how common multiband alleles might be in natural populations, and their existence will cause problems in the assessment of relatedness by band-sharing analysis. We believe, therefore, that a pedigree analysis should be included in all DNA fingerprinting studies, where possible, in order to estimate the number of loci identified by a minisatellite DNA probe and to examine the nature of their alleles.
TOSS: Traffic offloading by social network service-based opportunistic sharing in mobile social networks (2014)

The ever increasing traffic demand becomes a serious concern of mobile network operators. To solve this traffic explosion problem, there have been many efforts to offload the traffic from cellular links to direct communications among users. In this paper, we propose the framework of Traffic Offloading assisted by Social network services (SNS) via opportunistic Sharing in mobile social networks, TOSS, to offload SNS-based cellular traffic by user-to-user sharing. First we select a subset of users who are to receive the same content as initial seeds depending on their content spreading impacts in online SNSs and their mobility patterns in offline mobile social networks (MSNs). Then users share the content via opportunistic local connectivity (e.g., Bluetooth, Wi-Fi Direct, Device-to-device in LTE) with each other. The observation of SNS user activities reveals that individual users have distinct access patterns, which allows TOSS to exploit the user-dependent access delay between the content generation time and each user's access time for traffic offloading purposes. We model and analyze the traffic offloading and content spreading among users by taking into account various options in linking SNS and MSN trace data. The trace-driven evaluation demonstrates that TOSS can reduce up to 86.5% of the cellular traffic while satisfying the access delay requirements of all users.
Detection of human rotavirus by using an alkaline phosphatase-conjugated synthetic DNA probe in comparison with enzyme-linked immunoassay and polyacrylamide gel analysis (1989)

An alkaline phosphatase-conjugated synthetic oligodeoxyribonucleotide probe was compared with polyacrylamide gel electrophoresis (PAGE) detection of rotavirus RNA as well as an enzyme-linked immunosorbent assay (ELISA) for the detection of rotavirus in stools from young children with gastroenteritis. The synthetic probe did not cross-react with bacterial causative agents of diarrheal disease. Extraction of viral RNA from stool samples with a phenol-chloroform mixture was suitable for most samples. In some cases fecal pigments interfered with the reaction of the probe with viral RNA. The use of ion-exchange chromatography to further purify viral RNA removed contaminating pigments and increased the sensitivity of the probe assay. Of 260 stool specimens, 77 (30%) were positive for rotavirus when tested by PAGE analysis of rotavirus RNA. The synthetic probe identified 71 rotavirus specimens when RNA obtained by phenol-chloroform extraction followed by chromatographic purification was used (sensitivity, 91.0%; specificity, 96.7%). The ELISA results also agreed well with the electrophoretic analysis (sensitivity, 98.7%; specificity 94%) and the probe assay (sensitivity, 90%; specificity, 100%). Discordant results between the ELISA and the probe assay were examined further by electron microscopy and PAGE analysis of viral RNA. The positive and negative predictive values of the probe assay in comparison with PAGE were 92.2 and 96.1%, respectively. Rotaviruses showing both long and short RNA electrophoretic patterns were detected by the probe. The probe assay coupled with chromatographic purification of rotavirus RNA is an effective method for detecting rotavirus and compares favorably with PAGE analysis and ELISA.
Immunology for physicists (1997)

The immune system is a complex system of cells and molecules that can provide us with a basic defense against pathogenic organisms. Like the nervous system, the immune system performs pattern recognition tasks, learns, and retains a memory of the antigens that it has fought. The immune system contains more than ${10}^{7}$ different clones of cells that communicate via cell-cell contact and the secretion of molecules. Performing complex tasks such as learning and memory involves cooperation among large numbers of components of the immune system and hence there is interest in using methods and concepts from statistical physics. Furthermore, the immune response develops in time and the description of its time evolution is an interesting problem in dynamical systems. In this paper, the authors provide a brief introduction to the biology of the immune system and discuss a number of immunological problems in which the use of physical concepts and mathematical methods has increased our understanding.
Flip chip assembly on PCB substrates with coined solder bumps (2004)

This work was funded by Samsung Electro-Mechanics Co.
LTD in Korea. This work was also supported in part by
Center for Electronic Packaging Materials of Korea Science
and Engineering Foundation.
A mechanical evaluation of TiO<sub>2</sub>‐gritblasted and Ca‐P magnetron sputter coated implants placed into the trabecular bone of the goat: part 1 (2000)

The influence of Ca-P magnetron sputter coated implants on the mechanical anchorage was evaluated in a goat model. Therefore, uncoated and coated screw designed commercially pure titanium TiO2-blasted implants were inserted into the trabecular bone of the femoral condyles of 12 goats. The thicknesses of the coatings were 0.1 micron (CaP-0.1), 1.0 micron (CaP-1) and 4.0 microns (CaP-4). In addition, uncoated TiO2-blasted implants (Ti) were used as control. Evaluation of the interface strength and appearance, using torque test and scanning electron microscopy, was done at implantation periods of 6 and 12 weeks. Although, especially at 6 weeks of implantation, the Ca-P coated implants showed higher failure torque values than the TiO2 blasted implants, the observed differences for type of implant and evaluation period were not significant (P > 0.1). SEM evaluation showed that all implants with failure values of more than 100 N conducted bone growth into their screw threads. In addition, we observed that the fracture plane for the CaP-4 implants was situated at the coating-implant interface or inside the coating. For the CaP-1 and CaP-0.1 the fracture line could not be determined definitely. For the Ti implants, the fracture torque testing resulted in failure at the bone-implant interface. Therefore, we conclude that all implants resulted in a good bonding strength with the surrounding bone. The sputtered Ca-P coatings seemed to improve the initial fixation of the TiO2 blasted implants.
The Interaction of Direct Dyes with Water Soluble Substituted Celluloses and Cereal β-Glucans (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Interaction of Direct Dyes with Water Soluble Substituted Celluloses and Cereal β-GlucansPeter J. WoodCite this: Ind. Eng. Chem. Prod. Res. Dev. 1980, 19, 1, 19–23Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/i360073a006https://doi.org/10.1021/i360073a006research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The inflammation regulation effects of<i>Enterococcus faecium</i>HDRsEf1 on human enterocyte-like HT-29 cells (2016)

Enterococcus faecium HDRsEf1 strain used as a probiotic to inhibit intestine inflammation and improve animal growth performance has been proved by our research team; however, it remains unclear how HDRsEf1 was recognized by intestine cells and how it activates the downstream pathway which benefit intestine health. In this study, HDRsEf1 was used to stimulate HT-29 cell line to partially uncover the intestine benefit mechanism of HDRsEf1. The results of cell viability assays showed that HDRsEf1 had no toxicity on HT-29 at concentrations up to 1 × 108 CFU/mL, HDRsEf1 could upregulate the TLR1, TLR2, and TLR6 mRNA level, especially TLR2, and significantly downregulate the mRNA level of TLR4, TLR5, TLR7, TLR8, but did not significantly affect the mRNA or protein level of MyD88, which suggests that HDRsEf1 activates the TLR2 pathway in an MyD88-independent pattern. HDRsEf1 could significantly downregulate the mRNA level of pro-inflammatory factors IL-1β, IL-6, IL-8, IL-12p35, IL-17, and TNF-α and did not affect the anti-inflammatory factors IL-10, PPAR-γ, and TSLP; besides HDRsEf1 did not upregulate the degradation of IκB in HT-29 cells. By contrast, enterohemorrhagic E. coli (EHEC) O157:H7 strongly up-regulated the mRNA level of pro-inflammatory factors IL-1β, IL-6, IL-8, IL-23, and TNF-α, downregulated obviously anti-inflammatory factor PPAR-ɣ, and obviously upregulated the degradation of IκB, which suggested that HDRsEf1 may act as an antagonist to regulate intestine inflammation response to intestine pathogen. These findings shed a light on the intestine benefit mechanism of HDRsEf1.
Active compensators for ferroelectric-optical circuits (1971)

Disturb pulse and fatigue effects have prevented or limited the use of ferroelectric materials as matrix addressed arrays of light valves suitable for optical memories, page composers, displays and printers. These problems can be optically balanced out by building an array of compensators out of a second piece of ferroelectric and applying to the compensator array the same disturb and polarization reversal history that the light valve array receives. Experimental data obtained on a lanthanum doped lead zirconate titanate ferroelectric ceramic shows the effectiveness of the active compensator technique in balancing out the disturb pulse effect. The optical balancing technique is not limited to ferroelectrics, but can also be applied to other optically active materials which do not have an absolute switching threshold and/or decay. The balancing technique can also be used to overcome the problems of elastic switching, which would normally cause light to escape momentarily from a half selected valve.
Demographic correlates of urban development (1980)

The author examines the extent to which economic-demographic correlates within an urban area conform with those in a regional or international context. The relationships between selected demographic and economic variables are analyzed using data for the 46 largest Canadian Metropolitan areas and urban areas in 1951. (ANNOTATION)
Reputation-Based Byzantine Fault-Tolerance for Consortium Blockchain (2018)

The Practical Byzantine Fault Tolerance algorithm (PBFT)has been highly applied in consortium blockchain systems, however, this kind of consensus algorithm can hardly identify and remove faulty nodes in time, and also vulnerable to many attacks against the primary node of PBFT. The equality of consortium members' discourse rights is inapplicable to some real scenarios where dominating members are likely to have a larger discourse rights in the voting process. To address these problems, this paper presents Reputation-based Byzantine Fault Tolerance (RBFT)algorithm that incorporates a reputation model to evaluate the operations of each node in the consensus process. The faulty nodes will get lower discourse rights in the voting process if any malicious behavior is detected, with their reputation decreased. Furthermore, this paper presents an innovative reputation-based primary change scheme. The node with higher reputation obtains greater opportunities to be a primary to generate new valid blocks, which reduces the security risk of the primary. The experimental results demonstrate that RBFT gains better performance and ensures system security and reliability. Compared with PBFT, it increases the average throughput by 15% and reduces delay by 10%, and the faulty node rate of the system can continue to decrease over time.
The Effects of Ethanol on the Germination of Seeds of Japonica and Indica Rice (Oryza sativaL.) under Anaerobic and Aerobic Conditions (1997)

An examination was made of the effects of ethanol at 0n2-6n0% (v\v) on the germination, under aerobic conditions, of intact and dehusked seeds of indica rice (cv. Assam IV), which had been harvested 14, 21 and 28 d after anthesis, and of the japonica rice (cv. Sasanishiki), which had been harvested 30 and 60 d after anthesis. The inhibition of germination caused by dehusking japonica rice was overcome by 0n5-5 % ethanol, with maximum germination (frequently 100 %) achieved at 3-5 % (30 d after anthesis) or 1-4n5 % (60 d after anthesis) ethanol. Further increases in the ethanol concentration reduced germination. The germination of dehusked indica rice was slightly inhibited at 0n5 and 1 % ethanol, whilst the promotion of germination by 2 % ethanol increased as the seeds matured. At all harvests germination was greatest at 3 % ethanol, and at 5-6 % ethanol germination fell to 0 %. Inhibition, no effect, or minimal stimulation of the germination of intact seeds of both japonica and indica rice by ethanol was observed at the concentrations examined. The absence of oxygen stimulated germination of dehusked japonica rice, but this germination was inhibited by ethanol. In contrast ethanol had little or no effect on the failure of dehusked indica seeds to germinate in anaerobic conditions. Thus ethanol treatment may help break the strong dormancy of dehusked seeds of indica and japonica rice. The possible role of ethanol in stimulating germination in rice is discussed.
SLEVE: Semantic Locking for EVEnt synchronization (2002)

A method for implementing semantic synchronization specifications with ordinary read and write locks is presented. A software system, SLEVE, that implements the methodology is described. An application developer who defines a conflict relation over an arbitrary set of synchronization primitives, such as abstract type operations, events, or semantic lock types, can use SLEVE to implement the specification on an underlying system that supports only read/write locking. The method can be used to synchronize either transactions or processes, and it can be used in multiversioning schemes to control version proliferation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multimedia Semantic Integrity Assessment Using Joint Embedding Of Images And Text (2017)

Real-world multimedia data is often composed of multiple modalities such as an image or a video with associated text (e.g., captions, user comments, etc.) and metadata. Such multimodal data packages are prone to manipulations, where a subset of these modalities can be altered to misrepresent or repurpose data packages, with possible malicious intent. It is therefore important to develop methods to assess or verify the integrity of these multimedia packages. Using computer vision and natural language processing methods to directly compare the image (or video) and the associated caption to verify the integrity of a media package is only possible for a limited set of objects and scenes. In this paper we present a novel deep-learning-based approach that uses a reference set of multimedia packages to assess the semantic integrity of multimedia packages containing images and captions. We construct a joint embedding of images and captions with deep multimodal representation learning on the reference dataset in a framework that also provides image-caption consistency scores (ICCSs). The integrity of query media packages is assessed as the inlierness of the query ICCSs with respect to the reference dataset. We present the MultimodAl Information Manipulation dataset (MAIM), a new dataset of media packages from Flickr, which we are making available to the research community. We use both the newly created dataset as well as Flickr30K and MS COCO datasets to quantitatively evaluate our proposed approach. The reference dataset does not contain unmanipulated versions of tampered query packages. Our method is able to achieve F-1 scores of 0.75, 0.89 and 0.94 on MAIM, Flickr30K and MS COCO, respectively, for detecting semantically incoherent media packages.