gebhart/patrepeval huggingface dataset:
Snail and E47 repressors of<i>E-cadherin</i>induce distinct invasive and angiogenic properties in vivo (2004)

The transcription factors Snail and E47 are direct repressors of E-cadherin, with both inducing a full epithelial-mesenchymal transition and invasive behaviour in vitro when expressed in the prototypic epithelial MDCK cell line. The role of these repressors in the invasive process and in other tumorigenic properties is, nevertheless, still poorly understood. However, organotypic cultures and in vivo transplantation assays indicate that cells expressing MDCK-Snail and MDCK-E47 exhibit significant differences. MDCK-Snail cells have a higher infiltrative potential than MDCK-E47 cells. Interestingly, both cell types induce angiogenesis of the host stromal tissue in transplantation assays, but this property is greatly enhanced in transplants of MDCK-E47 cells. Xenografted tumours induced in nude mice also show signs of strong angiogenic potential, again markedly increased in tumours induced by MDCK-E47 which exhibit a higher vessel density and proliferation rate than those induced by MDCK-Snail cells. These results suggest differential roles for Snail and E47 E-cadherin repressors in tumour progression where Snail is implicated in promoting the initial invasion and E47 plays an active role in tumour cell growth by promoting angiogenesis.
A biosensor based on conducting polymers (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA biosensor based on conducting polymersD. T. Hoa, T. N. Suresh. Kumar, N. S. Punekar, R. S. Srinivasa, R. Lal, and A. Q. ContractorCite this: Anal. Chem. 1992, 64, 21, 2645–2646Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ac00045a031https://doi.org/10.1021/ac00045a031research-articleACS PublicationsRequest reuse permissionsArticle Views1049Altmetric-Citations181LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel age-dependent targets in vestibular schwannomas (2014)

Genes identified here may be additional aberrations in merlin-depleted cells that govern the disease onset. A significant number of these genes have been suggested as having a role in carcinogenesis and are used as biomarkers for prognosis in several other cancers. The role of these genes in NF2 carcinogenesis and their potential as biomarkers or drug target are worthwhile exploring.
Gateway vectors for the production of combinatorially‐tagged His<sub>6</sub>‐MBP fusion proteins in the cytoplasm and periplasm of <i>Escherichia coli</i> (2005)

Many proteins that accumulate in the form of insoluble aggregates when they are overproduced in Escherichia coli can be rendered soluble by fusing them to E. coli maltose binding protein (MBP), and this will often enable them to fold in to their biologically active conformations. Yet, although it is an excellent solubility enhancer, MBP is not a particularly good affinity tag for protein purification. To compensate for this shortcoming, we have engineered and successfully tested Gateway destination vectors for the production of dual His6MBP-tagged fusion proteins in the cytoplasm and periplasm of E. coli. The MBP moiety improves the yield and solubility of its fusion partners while the hexahistidine tag (His-tag) serves to facilitate their purification. The availability of a vector that targets His6MBP fusion proteins to the periplasm expands the utility of this dual tagging approach to include proteins that contain disulfide bonds or are toxic in the bacterial cytoplasm.
One-Shot Imitation Filming of Human Motion Videos (2019)

Imitation learning has been applied to mimic the operation of a human cameraman in several autonomous cinematography systems. To imitate different filming styles, existing methods train multiple models, where each model handles a particular style and requires a significant number of training samples. As a result, existing methods can hardly generalize to unseen styles. In this paper, we propose a framework, which can imitate a filming style by "seeing" only a single demonstration video of the same style, i.e., one-shot imitation filming. This is done by two key enabling techniques: 1) feature extraction of the filming style from the demo video, and 2) filming style transfer from the demo video to the new situation. We implement the approach with deep neural network and deploy it to a 6 degrees of freedom (DOF) real drone cinematography system by first predicting the future camera motions, and then converting them to the drone's control commands via an odometer. Our experimental results on extensive datasets and showcases exhibit significant improvements in our approach over conventional baselines and our approach can successfully mimic the footage with an unseen style.
A Ka-band cavity-backed patch antenna with parasitic strips using LTCC multilayer technology (2010)

This paper presents the design of a Ka-band cavity-backed patch antenna with parasitic strips using low temperature cofired ceramic (LTCC) multilayer technology. A cavity-backed structure consisting of a square ring of short-circuited metal plane is used to surround the microstrip patch antenna for alleviating the effect of the edge diffraction and reducing the backside radiation, hence, improving the radiation performance. Additionally, two groups of parasitic strips, mounted above two radiation side of the microstrip patch, act as directors to increase the gain, and also introduce resonant structures to broaden the bandwith. By the designed structure, a high maximum gain, about 8.3 dBi, is achieved; and the return loss better than -10dB bandwidth is over 23%, from 31 GHz to 39.3 GHz.
Le récepteur Toll-<i>like</i>8 (2012)

Toll-like receptors (TLR) sense a variety of microbial products and play an important role in the mounting of innate and adaptive immune responses. TLR1 to TLR9 are common in mice and humans and recognize similar ligands in both species, with the exception of TLR8. Human TLR7 and TLR8 and mouse TLR7 detect viral single-stranded RNA and imidazoquinoline compounds, while mouse TLR8 not. Based on this discrepancy, for long time it was believed that mouse TLR8 is not functional and as a consequence the contribution of TLR8 to innate immunity remained poorly understood. Our recent studies revealed an important role for TLR8 in the regulation of TLR7-mediated autoimmunity in the mouse. This review illustrates our current understanding regarding the function of TLR8 and its potential for future clinical use for the treatment and/or prevention of various pathological conditions.
Comparison of withdrawal phenomena after propranolol, metoprolol and pindolol. (1982)

1 After abrupt propranolol withdrawal a rebound increase in cardiac sensitivity to isoprenaline occurred in 9/9 patients and persisted up to 14 days. A mild brief rebound in resting heart rate occurred in 4/9 patients and a rebound in blood pressure occurred in 6/9 patients. These withdrawal phenomena were prevented by gradual withdrawal on a prolonged small dose of propranolol. 2 After abrupt metoprolol withdrawal a rebound increase in cardiac sensitivity to isoprenaline occurred in 8/8 patients but had resolved by 8 days. A marked persistent rebound in resting heart rate occurred in 8/8 patients while a small brief rebound in blood pressure occurred in only one patient. These withdrawal phenomena were largely prevented by gradual withdrawal on a prolonged small dose of metoprolol. 3 After abrupt pindolol withdrawal there was no rebound in isoprenaline sensitivity but a mild brief rebound in resting heart rate occurred in 9/10 patients. There was no rebound in blood pressure. 4 The type, magnitude and frequency of withdrawal phenomena after various beta-adrenergic receptor blockers probably reflects substantial differences in their basic pharmacological characteristics. 5 Caution must be exercised when withdrawing any patient from any beta-adrenoceptor blocker since an adverse cardiac event is unpredictable.
Water-Immersed Microwave Antennas and Their Application to Microwave Interrogation of Biological Targets (1979)

This paper describes a method of significantly improving the resolution of systems used for interrogating the spatial variation of permittivity of biosystems at S band. The basic principle employed is to contract the wavelength of the interrogating radiation and to reduce the physical aperture of the interrogating probes by immersing the transmitting antenna, receiving antenna, and the target into a material with a high dielectric constant, namely water. The antenna design is described, and line scans employing transmitted and reflected energy are presented.
Task-Based Speed and Voltage Scheduling on Windows 2000 (2002)

This paper describes RightSpeed, a task-based speed and voltage scheduler for Windows 2000. It takes advantage of the ability of certain processors, such as those from Transmeta and AMD, to dynamically change speed and voltage and thus to save energy while running more slowly. RightSpeed uses PACE, an algorithm that computes the most energy efficient way to meet task deadlines with high probability. Since most applications do not provide enough data about tasks, such as task deadlines, for PACE to work, RightSpeed uses simple and efficient heuristics to automatically detect task characteristics for such applications. We show that RightSpeed has only 1.2% background overhead and its operations take only a few microseconds each. It even performs PACE calculation, which is quite complicated, in only 4.4 mus on average due to our extensive optimizations. We show that RightSpeed is effective at meeting performance targets set by applications to within 1.5%. We show that although the PACE calculator does not save energy for the current generation of processors due to their limited range of worthwhile speed and voltage settings, we expect future processors to have greater such ranges, enabling PACE to reduce CPU energy consumption by 6.1-8.7% relative to the best standard algorithm. Finally, we show that with PACE, giving a processor the ability to run at additional, higher speeds and voltages reduces overall energy consumption
Anti-Allergic Effect of Oroxylin A from <i>Oroxylum indicum</i> Using <i>in vivo</i> and <i>in vitro</i> Experiments (2016)

Oroxylum indicum has long been used in Asian traditional medicine to prevent and treat respiratory diseases, diabetes, diarrhea and other conditions. Oroxylin A is a flavone that is present in Oroxylum indicum and in Scutellaria baicalensis. Because the root extracts of both plants have been shown to have anti-allergic effects, the authors investigated whether oroxylin A is likely to have beneficial effects on allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells. Antigen-induced degranulation was measured in vitro by measuring β-hexosaminidase activity. A murine ovalbumin-induced allergic asthma model was used to test the in vivo efficacy of oroxylin A. Sensitization and challenge of ovalbumin induced allergic asthma responses, the accumulations of eosinophils and Th2 cytokine levels in bronchoalveolar lavage fluid and lung tissues. Oroxylin A administration decreased numbers of inflammatory cells, especially eosinophils, and reduced the expression and secretion of Th2 cytokines, including IL-4 and IL-13, in lung tissues and bronchoalveolar lavage fluid. Histologic studies showed oroxylin A reduced inflammatory signs and mucin production in lungs. These findings provide evidence that oroxylin A has potential use as an anti-allergic therapeutic.
Multiple Layer Techniques In Optical Lithography: Applications To Fine Line Mos Production (1984)

The theory and practical concerns of multi-layer techniques using an anti-reflective polymer coating will be discussed. Anti Reflective Coating (ARC, Brewer Science, Inc.) was incorporated into the metal lithography process for a 1.2 micron gate CMOS prototype production line. Previously, reflections from substrate topography had caused a loss in linewidth control. These reflections were minimized by the ARC, which also restored process latitude. For the process described, ARC coating uniformity was ± nm, adhesion was good, and step coverage was seen to be adequate to 0.8 micron high verticle wall steps.
Non-Invasive Silent Phoneme Recognition Using Microwave Signals (2018)

Besides the recognition of audible speech, there is currently an increasing interest in the recognition of silent speech, which has a range of novel applications. A major obstacle for a wide spread of silent-speech technology is the lack of measurement methods for speech movements that are convenient, non-invasive, portable, and robust at the same time. Therefore, as an alternative to established methods, we examined to what extent different phonemes can be discriminated from the electromagnetic transmission and reflection properties of the vocal tract. To this end, we attached two Vivaldi antennas on the cheek and below the chin of two subjects. While the subjects produced 25 phonemes in multiple phonetic contexts each, we measured the electromagnetic transmission spectra from one antenna to the other, and the reflection spectra for each antenna (radar), in a frequency band from 2-12 GHz. Two classification methods (k-nearest neighbors and linear discriminant analysis) were trained to predict the phoneme identity from the spectral data. With linear discriminant analysis, cross-validated phoneme recognition rates of 93% and 85% were achieved for the two subjects. Although these results are speaker- and session-dependent, they suggest that electromagnetic transmission and reflection measurements of the vocal tract have great potential for future silent-speech interfaces.
Modular neural predictive coding for discriminative feature extraction (2003)

We present an architecture called the modular neural predictive coding architecture (Modular NPC). The Modular NPC is used for discriminative feature extraction (DFE). It provides an architecture based on phonetics knowledge applied to phoneme recognition. The phonemes are extracted from the Darpa-Timit speech database. Comparisons with coding methods (LPC, MFCC, PLP) are presented: they put in obviousness an improvement of the recognition rates.
Recycling of a Cyclic Thermoplastic Composite Material by Injection and Compression Molding (1994)

One of the primary projected advantages of the new cyclic thermoplastic- based composites, in addition to their ability to be processed by liquid composite molding, is their potential "recyclability." This paper describes a first attempt to prove the technical feasibility of recycling a cyclic polycarbonate-matrix continuous-glass-fiber composite by two common processes: compression molding and injection molding. The results are somewhat mixed but still encouraging. Parts were reprocessed from ground-up continuous-fiber composites by both injection molding and compression molding. The effects of environmental exposure (water and ethylene glycol) on the composite prior to recycling were also investigated. The injection molded parts exhibited excellent mechanical properties, in some cases exceeding those of the analogous commercially available injection molding grade. The compression molded recycled material, however, showed very poor tensile properties, but its impact properties compared well to comparable commercial materials. The mixed performance of the compression molded material was characterized by microstructural inhomogeneity and matrix microcracks thought to be due to processing deficiencies. Work continues toward improving the quality of these cyclic thermoplastic materials and the recycling processes.
Type-of-service routing in dynamic datagram networks (2002)

The authors propose a new approach to achieving type-of-service (TOS) with adaptive next-hop routing in wide-area networks such as the Internet. They consider two traffic classes, namely delay-sensitive and throughput-sensitive. Their approach attempts to isolate the two traffic classes by using two FCFS queues at each out-going link, one for each TOS; the link is shared cyclicly between the two TOS queues. The next-hops for the delay-sensitive traffic adapts to link delays of that traffic. The next-hops for the throughput-sensitive traffic adapts to overall link utilizations. They compare their approach with a traditional approach using discrete-event simulation and Lyapunov analysis (for stability of routes). Because of the isolation feature, the proposed approach offers lower end-to-end delays for both traffic classes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Silence of Understanding (1943)

Research Article| March 08 1943 Silence of Understanding Harriet L. Moore Harriet L. Moore Search for other works by this author on: This Site PubMed Google Scholar Far Eastern Survey (1943) 12 (5): 45–46. https://doi.org/10.2307/3023099 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Harriet L. Moore; Silence of Understanding. Far Eastern Survey 8 March 1943; 12 (5): 45–46. doi: https://doi.org/10.2307/3023099 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAsian Survey Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Prospects for Advancing Tuberculosis Control Efforts through Novel Therapies (2006)

The introduction of new, shorter treatment regimens could dramatically accelerate the reductions in TB incidence and mortality that are expected under current regimens-with up to 2- or 3-fold increases in rates of decline if shorter regimens are accompanied by enhanced case detection. Continued progress in reducing the global TB burden will require a balanced approach to pursuing new technologies while promoting wider implementation of proven strategies.
Browser-based applications (2004)

Applications that run on top of web browsers dominate the Internet today. Given the many similarities among these applications' features, positive transference from one to another is often seen as an important source of ease-of-use for such applications. This paper examines the many differences in the way similar features are implemented in different browser-based applications, analyzing the way these inconsistencies can lead to negative transference (interference) that degrades rather than enhances usability.
Oscillating foils of high propulsive efficiency (1998)

Thrust-producing harmonically oscillating foils are studied through force and power measurements, as well as visualization data, to classify the principal characteristics of the flow around and in the wake of the foil. Visualization data are obtained using digital particle image velocimetry at Reynolds number 1100, and force and power data are measured at Reynolds number 40 000. The experimental results are compared with theoretical predictions of linear and nonlinear inviscid theory and it is found that agreement between theory and experiment is good over a certain parametric range, when the wake consists of an array of alternating vortices and either very weak or no leading-edge vortices form. High propulsive efficiency, as high as 87%, is measured experimentally under conditions of optimal wake formation. Visualization results elucidate the basic mechanisms involved and show that conditions of high efficiency are associated with the formation on alternating sides of the foil of a moderately strong leading-edge vortex per half-cycle, which is convected downstream and interacts with trailing-edge vorticity, resulting eventually in the formation of a reverse Kármán street. The phase angle between transverse oscillation and angular motion is the critical parameter affecting the interaction of leading-edge and trailing-edge vorticity, as well as the efficiency of propulsion.
Performance Analysis of Unsupervised Machine Learning Techniques for Network Traffic Classification (2015)

Network traffic classification is important for QoS, Network management and security monitoring. Current method for traffic classification such as port based or payload based suffered many problems. Newly emerged application uses encryption and dynamic port numbers to avoid detection. So we use unsupervised machine learning approach to classify the network traffic. In this paper unsupervised K-means and Expectation Maximization algorithm are used to cluster the network traffic application based on similarity between them. Performance of these two algorithms is compared in terms of classification accuracy between them. The experiment results show that K-Means and EM perform well but accuracy of K-Means is better than EM and it form better cluster.
Macromol. Chem. Phys. 21/2012 (2012)

Front Cover: The symmetric 1,26-diacid and 1,26-diol, both prepared from erucic acid by olefin self-metathesis, were polymerized to yield long-chain aliphatic polyesters. Their renewable origin and possible biodegradability make them attractive candidates to be used as replacement of petroleum-based plastics. For more information, see the Full Paper by C. Vilela, A. J. D. Silvestre, and M. A. R. Meier* on page 2220.
A classification of data quality assessment and improvement methods (2014)

Data quality (DQ) assessment and improvement in larger information systems would often not be feasible without using suitable ‘DQ methods’, which are algorithms that can be automatically executed by computer systems to detect and/or correct problems in datasets. Currently, these methods are already essential, and they will be of even greater importance as the quantity of data in organisational systems grows. This paper provides a review of existing methods for both DQ assessment and improvement and classifies them according to the DQ problem and problem context. Six gaps have been identified in the classification, where no current DQ methods exist, and these show where new methods are required as a guide for future research and DQ tool development.
Activity of human Δ5 and Δ6 desaturases on multiple n‐3 and n‐6 polyunsaturated fatty acids (2001)

Yeast co-expressing human elongase and desaturase genes were used to investigate whether the same desaturase gene encodes an enzyme able to desaturate n-3 and n-6 fatty acids with the same or different carbon chain length. The results clearly demonstrated that a single human Delta5 desaturase is active on 20:3n-6 and 20:4n-3. Endogenous Delta6 desaturase substrates were generated by providing to the yeast radiolabelled 20:4n-6 or 20:5n-3 which, through two sequential elongations, produced 24:4n-6 and 24:5n-3, respectively. Overall, our data suggest that a single human Delta6 desaturase is active on 18:2n-6, 18:3n-3, 24:4n-6 and 24:5n-3.