gebhart/patrepeval huggingface dataset:
Synthesis and enzymic evaluation of some N-alkyl branched chain piperidine salts and N-alkyl-3-(N,N-diethylcarbamoyl)piperidine salts as inhibitors of acetyl- and butyrylcholinesterase (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and enzymic evaluation of some N-alkyl branched chain piperidine salts and N-alkyl-3-(N,N-diethylcarbamoyl)piperidine salts as inhibitors of acetyl- and butyrylcholinesteraseJames W. Stanley, Ian W. Mathison, and James G. BeasleyCite this: J. Med. Chem. 1974, 17, 1, 8–12Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/jm00247a003https://doi.org/10.1021/jm00247a003research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Writing on Dirty Paper with Feedback (2005)

Writing on dirty paper" refers to the communication problem over a channel with both noise and interference, where the interference is known to the encoder non-causally and unknown to the decoder. This problem is regarded as a basic building block in both the single-user and multiuser communications, and it has been extensively investigated by Costa and other researchers.
Effect of subaperture beamforming on phase coherence imaging (2014)

High-frame-rate echocardiography using unfocused transmit beams and parallel receive beamforming is a promising method for evaluation of cardiac function, such as imaging of rapid propagation of vibration of the heart wall resulting from electrical stimulation of the myocardium. In this technique, high temporal resolution is realized at the expense of spatial resolution and contrast. The phase coherence factor has been developed to improve spatial resolution and contrast in ultrasonography. It evaluates the variance in phases of echo signals received by individual transducer elements after delay compensation, as in the conventional delay-andsum beamforming process. However, the phase coherence factor suppresses speckle echoes because phases of speckle echoes fluctuate as a result of interference of echoes. In the present study, the receiving aperture was divided into several subapertures, and conventional delay-and-sum beamforming was performed with respect to each subaperture to suppress echoes from scatterers except for that at a focal point. After subaperture beamforming, the phase coherence factor was obtained from beamformed RF signals from respective subapertures. By means of this procedure, undesirable echoes, which can interfere with the echo from a focal point, can be suppressed by subaperture beamforming, and the suppression of the phase coherence factor resulting from phase fluctuation caused by such interference can be avoided. In the present study, the effect of subaperture beamforming in high-frame-rate echocardiography with the phase coherence factor was evaluated using a phantom. By applying subaperture beamforming, the average intensity of speckle echoes from a diffuse scattering medium was significantly higher (-39.9 dB) than that obtained without subaperture beamforming (-48.7 dB). As for spatial resolution, the width at half-maximum of the lateral echo amplitude profile obtained without the phase coherence factor was 1.06 mm. By using the phase coherence factor, spatial resolution was improved significantly, and subaperture beamforming achieved a better spatial resolution of 0.75 mm than that of 0.78 mm obtained without subaperture beamforming.
74.4: A Novel Ultra Thin Backlight System without Optical Sheets Using a Newly Developed Multi‐Layered Light‐guide (2010)

Abstract We describe a backlight system using a newly developed Multi‐Layered Light‐guide (MLL). MLL can perform as a backlight without additional optical sheets such as prism sheets or diffusers. It was developed as a multi‐layer sheet featuring different refractive indexes on different layers. A prototype was built, and the principles were confirmed in comparison with the theory. with a thickness of 0.514 mm, the built prototype is the thinnest backlight in the world, using only MLL without additional optical sheets.
Influence of Secretin on the Course of Acute Experimental Pancreatitis in Rats (1983)

Inhibition of pancreatic secretion is a widely accepted therapeutical principle of acute pancreatitis. However, stimulation of water and bicarbonate secretion may be beneficial by washing out the ductular system in pancreatitis. Secretin (2 and 16 CU/kg body weight) or saline were given to rats at different time intervals after induction of sodium taurocholate pancreatitis. Pancreatic necrosis and edema were slightly more marked after secretin but secretin had no influence on the survival time and rate or enzymatic parameters. It is concluded that in the rat secretin-induced pancreatic secretion does not alter the course of acute pancreatitis.
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole. (1970)

Summary Guanazole (3,5-diamino-1,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and uridine into DNA to a much greater extent than into RNA in L1210 leukemia cells in vivo . Thymidine incorporation into DNA was inhibited with concomitant accumulation of dTTP in L1210 cells. Leucine incorporation into protein was not inhibited. The incorporation of formate- 14 C into purine nucleotides was partially inhibited by guanazole and was accompanied by decreased labeling of nucleic acids; the effect on DNA synthesis was more pronounced than that on RNA. Similar results were obtained in human epidermoid carcinoma cells in culture. Guanazole inhibited the reduction of ribonucleotides to deoxyribonucleotides catalyzed by enzyme preparations from human epidermoid carcinoma cells. The effects of guanazole on DNA synthesis and on ribonucleotide reductase were similar to those of hydroxyurea. The experimental evaluation of guanazole against L1210 leukemia showed that dosage scheduling and route of implantation of L1210 cells were determining factors in the efficacy of the drug. When guanazole was given i.p. every 3 hr for 8 doses for a least 3 courses of treatment (Days 1, 5, and 9) after i.p. implantation of 10 5 L1210 cells, significant numbers of mice survived. In this respect also, the compound was similar to hydroxyurea.
Die Ertragsteuerarten (1989)

Unter der Bezeichnung „Ertragsteuern“ versteht dieses Buch
GaAs E/D MESFET 1-kbit static RAM fabricated on silicon substrate (1987)

A GaAs enhancement/depletion (E/D) MESFET 1-kbit static RAM has been fabricated on a 2-in GaAs-on-Si substrate. This is the most complex GaAs circuit reported to date for GaAs-on-Si material. The GaAs layer is grown on a (100) silicon wafer by MBE. Excellent threshold voltage uniformity has been obtained for enhancement- and depletion-mode MESFET's. The row-address access time of the 1-kbit SRAM is 6-14 ns compared with 4-12 ns for bulk GaAs chips fabricated concurrently using the identical E/D MESFET process. The total power dissipation, of less than 500 mW, is also comparable to the bulk GaAs chips.
Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: A methodological comparison (2006)

Mature circulating endothelial cells (CECs) are novel cellular markers of endothelial damage/dysfunction. The two main techniques of CEC enumeration are flow cytometry (FC) and immunomagnetic bead (IB) isolation. Both quantify CECs accurately, but a direct comparison of both methods has not been reported. We sought to assess the agreement between the two methods in two patient populations, and a group of healthy subjects, with emphasis given to methodological issues. We included 34 patients with acute coronary syndrome (ACS), 60 patients with primary breast cancer (PBC) and 30 healthy controls (HC). We quantified CECs using the IB method [CD146 and FITCUlex europaeus lectin-1] and FC [CD45, CD34 and CD146]. Bland-Altman plots suggested reasonable agreement (<5% of events >2 standard deviations from the mean) between FC and the IB methods for CEC quantification in whole blood in the two disease groups (ACS and PBC), but not among the HCs. There were no statistically significant differences in CEC levels by the two methods amongst all three patient groups. There is reasonable agreement between the FC and the IB methods for mature CEC quantification in whole blood, especially amongst disease groups. The agreement between the two methods appears to weaken in healthy controls, and at lower and higher absolute CEC counts.
Antifungal Susceptibility Survey of 2,000 Bloodstream <i>Candida</i> Isolates in the United States (2003)

Candida bloodstream isolates (n = 2,000) from two multicenter clinical trials carried out by the National Institute of Allergy and Infectious Diseases Mycoses Study Group between 1995 and 1999 were tested against amphotericin B (AMB), flucytosine (5FC), fluconazole (FLU), itraconazole (ITR), voriconazole (VOR), posaconazole (POS), caspofungin (CFG), micafungin (MFG), and anidulafungin (AFG) using the NCCLS M27-A2 microdilution method. All drugs were tested in the NCCLS-specified RPMI 1640 medium except for AMB, which was tested in antibiotic medium 3. A sample of isolates was also tested in RPMI 1640 supplemented to 2% glucose and by using the diluent polyethylene glycol (PEG) in lieu of dimethyl sulfoxide for those drugs insoluble in water. Glucose supplementation tended to elevate the MIC, whereas using PEG tended to decrease the MIC. Trailing growth occurred frequently with azoles. Isolates were generally susceptible to AMB, 5FC, and FLU. Rates of resistance to ITR approached 20%. Although no established interpretative breakpoints are available for the candins (CFG, MFG, and AFG) and the new azoles (VOR and POS), they all exhibited excellent antifungal activity, even for those strains resistant to the other aforementioned agents.
Minimum Variance Distortionless Response Beamformer with Enhanced Nulling Level Control via Dynamic Mutated Artificial Immune System (2014)

In smart antenna applications, the adaptive beamforming technique is used to cancel interfering signals (placing nulls) and produce or steer a strong beam toward the target signal according to the calculated weight vectors. Minimum variance distortionless response (MVDR) beamforming is capable of determining the weight vectors for beam steering; however, its nulling level on the interference sources remains unsatisfactory. Beamforming can be considered as an optimization problem, such that optimal weight vector should be obtained through computation. Hence, in this paper, a new dynamic mutated artificial immune system (DM-AIS) is proposed to enhance MVDR beamforming for controlling the null steering of interference and increase the signal to interference noise ratio (SINR) for wanted signals.
Detecting bittorrent blocking (2008)

Recently, it has been reported that certain access ISPs are surreptitiously blocking their customers from uploading data using the popular BitTorrent file-sharing protocol. The reports have sparked an intense and wide-ranging policy debate on network neutrality and ISP traffic management practices. However, to date, end users lack access to measurement tools that can detect whether their access ISPs are blocking their BitTorrent traffic. And since ISPs do not voluntarily disclose their traffic management policies, no one knows how widely BitTorrent traffic blocking is deployed in the current Internet. In this paper, we address this problem by designing an easy-to-use tool to detect BitTorrent blocking and by presenting results from a widely used public deployment of the tool.
Optimized Design For A Single-Sensor Color Electronic Camera System (1989)

A method used to develop an optimized design for a single-sensor color electronic camera is described. A color filter array (CFA) that senses red (R), green (G), and blue (B) information in a manner consistent with the relative sensitivities of the human visual system (HVS), an optical prefilter, and an optimized image reconstruction scheme are utilized in this system which maximizes image quality for a given number of pixels on a sensor.
Inheritance of Glycinin Subunits and Characterization of Glycinin Molecules Lacking the Subunits in Soybean (Glycine max (L.) Merr.). (1996)

We report the inheritance of the 11S globulin (glycinin) subunits and results of evaluating progenies lacl(ing these subunits in order to breed soybean varieties having different glycinin subunit compositions. F2 seeds from a cross between a mutant soybean line lacking group I (A1*B2, A1bB1b and A2B1*) and A5A4B3 subunits and a wild soy-bean (Glycine soja) accession lacking A3B4 subunit were examined for glycinin subunits by SDS-PAGE. The segregation for the presence or absence of the glycinin sub-units fitted well for independent inheritance among the three loci containing the group I, A5A4B3 and A3B4 sub-unit genes, respectively. Due to this fact, we propose here that the group 11 including A5A4B3 and A3B4 subunits can be classified into two subgroups, IIa (A5A4B3 subunit) and IIb (A3B4 subunit). F1 plants obtained from a cross between cv.
The use of radioactive 7α, 17α‐dimethyl‐19‐nortestosterone (mibolerone) in the assay of androgen receptors (1984)

Tritiated 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT; mibolerone), a synthetic androgen stable to metabolic conversion in the rat ventral prostate, is an excellent radioactive ligand for the quantitation and characterization of androgen receptors in prostate, liver, and cultured cells. DMNT is more receptor-selective than 17 alpha-methyl-17 beta-hydroxy-estra-4,9,11-trien-3-one (R1881); DMNT interacts with glucocorticoid and progestin receptors much less strongly than R1881. Unlike 5 alpha-dihydrotestosterone, DMNT does not bind tightly to testosterone-estradiol binding globulin of human serum. The hydroxylapatite-filter assay we employed can clearly distinguish between DMNT binding to androgen receptors of rat ventral prostate and interaction of DMNT with androgen binding protein of epididymides. The prostate cytosol (3H)DMNT-receptor complex sediments in two forms (4 and 8 S) in a low salt medium. In 0.4 M KCl, both the prostate cytosol and nuclear (3H)DMNT-receptor complexes migrated as 3-4 S components. The formation of both the cytosol and nuclear DMNT-receptor complexes is inhibited by antiandrogens and 17 beta-estradiol.
Application of Virtual Reality Graphics in Assessment of Concussion (2006)

Abnormal balance in individuals suffering from traumatic brain injury (TBI) has been documented in numerous recent studies. However, specific mechanisms causing balance deficits have not been systematically examined. This paper demonstrated the destabilizing effect of visual field motion, induced by virtual reality graphics in concussed individuals but not in normal controls. Fifty five student-athletes at risk for concussion participated in this study prior to injury and 10 of these subjects who suffered MTBI were tested again on day 3, day 10, and day 30 after the incident. Postural responses to visual field motion were recorded using a virtual reality (VR) environment in conjunction with balance (AMTI force plate) and motion tracking (Flock of Birds) technologies. Two experimental conditions were introduced where subjects passively viewed VR scenes or actively manipulated the visual field motion. Long-lasting destabilizing effects of visual field motion were revealed, although subjects were asymptomatic when standard balance tests were introduced. The findings demonstrate that advanced VR technology may detect residual symptoms of concussion at least 30 days post-injury.
A New Family of Liquid Crystals: N-Substituted Aldonamides II: Relationship Between Chemical Structure and the Formation of Mesophases (1986)

Abstract A series of N-substituted aldonamides has been synthesized. Some of these compounds form a thermotropic lamellar mesophase in which molecules in the trans-configuration are arranged in monolayers stabilized by hydrogen bonding and hydrophobic interactions. X-ray diffraction studies have shown that a molecular arrangement of this type exists in the crystalline solid of N-decylribonamide. The relationship between the mesogenic properties and the molecular structures of these compounds is discussed (with reference to the length, branching and cyclisation of the aldonic residue and of the hydrocarbon chain). Key Words: N-aldonamideslamellar thermotropic phasecrystal structure determination
DNA Polymorphisms of Apolipoprotein B and Angiotensin I-Converting Enzyme Genes and Relationships with Lipid Levels in Italian Patients with Vascular Dementia or Alzheimer’s Disease (1998)

The distribution of three DNA polymorphisms (XbaI, EcoRI, and I/D) of the apolipoprotein B (APOB) gene, and of the I/D polymorphism of the angiotensin I-converting enzyme (ACE) gene was investigated in 53 patients with vascular dementia, in 80 patients with late-onset sporadic Alzheimer's disease, and in 153 age-matched control subjects. Furthermore, plasma total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured in the three groups and the involvement of the genetic variation at APOB locus on lipid levels was determined. Major findings of this work are (1) no genotype or allele of the polymorphisms examined here seemed to be associated with vascular dementia or with Alzheimer's disease, (2) total cholesterol and LDL cholesterol levels were lower in Alzheimer's disease patients than in vascular dementia patients and in elderly controls, and (3) the dementia patients with APOB EcoRI R+R- genotype had higher total cholesterol and LDL cholesterol levels than R+R+ homozygotes.
A Forward Collision Warning Algorithm Based on Driver Characteristics (2010)

As a part of Driver Assistance Systems (DAS), the Forward Collision Warning System (FCWS) can effectively avoid forward collision accidents and improve traffic safety. Based on the Drivers' Behavior Questionnaire (DBQ), five clusters were defined by the cluster analysis in this paper. Meanwhile, on the basis of the driver behavior experiments on the passenger vehicle, and TTC strategy, a forward collision warning algorithm in accordance with the driver characteristics is presented. In this research, it is the key of the strategy to determine the warning-start logic and statistically estimate the warning threshold. Finally, the experiment results demonstrate that the algorithm is able to embody various types of driver characteristics and enhance the acceptance of FCWS.
Multi-User Location Correlation Protection with Differential Privacy (2016)

In the big data era, with the rapid development of location-based applications, GPS enabled devices and big data institutions, location correlation privacy raises more and more people's concern. Because adversaries may combine location correlations with their background knowledge to guess users' privacy, such correlation should be protected to preserve users' privacy. In order to deal with the location disclosure problem, location perturbation and generalization have been proposed. However, most proposed approaches depend on syntactic privacy models without rigorous privacy guarantee. Furthermore, many approaches only consider perturbing the locations of one user without considering multi-user location correlations, so these techniques cannot prevent various inference attacks well. Currently, differential privacy has been regarded as a standard for privacy protection, but there are new challenges for applying differential privacy in the location correlations protection. The privacy protection not only should meet the needs of users who request location-based services, but also should protect location correlation among multiple users. In this paper, we propose a systematic solution to protect location correlations privacy among multiple users with rigorous privacy guarantee. First of all, we propose a novel definition, private candidate sets which are obtained by hidden Markov models. Then, we quantify the location correlation between two users by using the similarity of hidden Markov models. Finally, we present a private trajectory releasing mechanism which can preserve the location correlations among users who move under hidden Markov models in a period of time. Experiments on real-world datasets also show that multi-user location correlation protection is efficient.
Laboratory Method for Corrosion Inhibitor Evaluation (1956)

A screening method has been developed which permits rapid, convenient testing of inhibitors. Unlike weight-loss methods, this new method is well adapted to follow non-linear corrosion-time curves, such as those commonly found when adsorption-type inhibitors are used. The method makes use of quart bottles containing the corrosive agents; the bottles are rotated end over end at about three rpm. This rotation brings about alternate immersion of test probes where the corrosive system consists of two or more phases. The test probes are used to follow the course of corrosion without requiring the bottles to be opened. A probe consists of a corroding specimen (metal ribbon) to which is attached a protected specimen serving as a temperature-compensating element. These specimens form two arms of a resistance-measuring bridge. Electrical leads, brought through the rubber stopper to the outside of the bottle, permit the probe to be connected when desired to a bridge circuit which internally converts any change in resistance to loss of metal thickness. The corrosion loss in millionths of an inch is read directly from a meter and can be followed conveniently during the course of the test. An application of the method in testing gasoline rust inhibitors is discussed. 5.8.1
Ultrasound enhanced ferrite plating; bringing breakthrough in ferrite coating synthesized from aqueous solution (1997)

Applying power ultrasound waves (19.5 kHz, 600 W) to 300 ml of FeCl/sub 2/ aqueous solution (pH=7.0) at 70/spl deg/C, we successfully encapsulated polyacrylate spheres of two sizes, 0.25 /spl mu/m and 4.5 /spl mu/m in average diameter, with ferrite coatings of a magnetite-maghemite mixed solution. This broke the previous lower limit (0.3 /spl mu/m) of the size of the particles to be encapsulated; without application of the ultrasound waves, the ferrite coating became discontinuous or insular. The ultrasound waves produce on the polymer surfaces OH groups (which work as ferrite nucleation sites), and remove the isolated ferrite particles (grown from the solution) from the surface of the ferrite coatings. This improved the surface quality of the ferrite coatings. The ferrite-encapsulated particles will greatly improve the performance of the enzyme immunoassay, which has been put to clinical use as a cancer test reagent with insular-ferrite-coated particles.