gebhart/patrepeval huggingface dataset:
Shared Syntax in Language Production and Language Comprehension--An fMRI Study (2011)

During speaking and listening syntactic processing is a crucial step. It involves specifying syntactic relations between words in a sentence. If the production and comprehension modality share the neuronal substrate for syntactic processing then processing syntax in one modality should lead to adaptation effects in the other modality. In the present functional magnetic resonance imaging experiment, participants either overtly produced or heard descriptions of pictures. We looked for brain regions showing adaptation effects to the repetition of syntactic structures. In order to ensure that not just the same brain regions but also the same neuronal populations within these regions are involved in syntactic processing in speaking and listening, we compared syntactic adaptation effects within processing modalities (syntactic production-to-production and comprehension-to-comprehension priming) with syntactic adaptation effects between processing modalities (syntactic comprehension-to-production and production-to-comprehension priming). We found syntactic adaptation effects in left inferior frontal gyrus (Brodmann's area [BA] 45), left middle temporal gyrus (BA 21), and bilateral supplementary motor area (BA 6) which were equally strong within and between processing modalities. Thus, syntactic repetition facilitates syntactic processing in the brain within and across processing modalities to the same extent. We conclude that that the same neurobiological system seems to subserve syntactic processing in speaking and listening.
Control of the coupled motion of a 6 DoF robotic arm and a continuum manipulator for the treatment of pelvis osteolysis (2014)

The paper addresses the coupled motion of a 6 degree of freedom robot and a snake-like dexterous manipulator (SDM) designed for the treatment of bone defects behind the implant during total hip arthroplasty revision surgery. We have formulated the problem as a weighted, multi-objective constraint, linear optimization. A remote center of motion (RCM) acts as a virtual constraint for the robot. The coupled robot kinematics does not assume piecewise-constant curvature for the SDM. We have evaluated our method by simulating the coupled system inside a potential lesion area.
BoostPred: An Automatic Demand Predictor for the Cloud (2011)

As Cloud Computing adoption by enterprise customers grows, so too the need for optimal utilisation of their virtual resources. Likewise, cost pressures on cloud providers with a utility business model e.g. Amazon Web Services, would also need to optimise the utilisation of their physical infrastructure. Clearly, the ability to predict demand would be valuable. We introduce Boost red, an automatic demand predictor for the cloud. BoostPred's design goals are to require no human expert intervention in making accurate predictions from noisy real world demand signals. We evaluate the accuracy of Boost red using noisy real-world signals which reveal its potential and current shortcomings.
Endothelium‐dependent modulation of pacemaking in lymphatic vessels of the guinea‐pig mesentery. (1996)

1. Endothelial control of the rate of constrictions and the underlying pacemaker potentials has been studied in vitro in guinea-pig mesenteric lymphatic vessels. 2. ACh stimulated 60% of intraluminally perfused vessels to slow or abolish lymphatic constrictions. This action was inhibited by atropine and was likely to be due to the release of endothelium-derived nitric oxide (EDNO) as the effect was absent after endothelial lysis, mimicked by sodium nitroprusside (SNP), blocked by N omega-nitro L-arginine (NOLA) and partially inhibited by Methylene Blue (MB). 3. The remaining 40% of perfused vessels did not mechanically respond to ACh or SNP. In four of seven such vessels this appeared to be due to excessive perfusion-associated release of EDNO, as incubation with NOLA restored the response to SNP. 4. Application of NOLA or MB in perfused vessels significantly increased constriction frequency, further indicating perfusion-associated release of EDNO. 5. ACh induced a marked increase in endothelial [Ca2+]i of both mechanically responding and non-responding vessels. This ACh-induced increase could be repetitively induced when Ca2+ was present in the perfusate, but rapidly ran down when a Ca(2+)-free EGTA perfusate was used. 6. Intracellular recordings from the smooth muscle of non-perfused vessel segments demonstrated an ACh-induced hyperpolarization and decrease in membrane resistance, changes which were prevented by atropine, NOLA, MB and endothelial lysis and mimicked by SNP. 7. ACh directly reduced the size of the underlying pacemaker potentials termed spontaneous transient depolarizations (STDs). 8. NOLA and MB enhanced STDs in non-perfused vessel segments indicating an endogenous release of EDNO. 9. It is concluded that the lymphatic endothelium produces and releases EDNO endogenously, during perfusion or after stimulation with ACh, to decrease the efficacy of STDs to generate action potentials and resultant constrictions.
Remote Monitoring of Free Flaps with Telephonic Transmission of Photoplethysmograph Waveforms (1989)

Analog waveforms from bedside photoplethysmograph flap-monitoring devices have been transmitted via telephone lines to remote monitoring stations. Two methods for data transfer have been successfully used in clinical practice. One employs equipment similar to that used for transmission of EKG signals; the second uses paired microcomputers linked with telephone modems. These readily available technologies enable remote evaluation of the adequacy of perfusion of free tissue transfers.
Oral hypoglycemic agents. Pyrimido[1,2-a]indoles and related compounds (1992)

A series of pyrimido[1,2-a]indoles were synthesized and studied for their hypoglycemic activity following oral administration at a standard dose of 100 mg/kg to fed rats. The effect of 10-alkoxyalkyl, 10-alkyl, 10-aryl, and 3,3-dialkyl substitution on the activity of 10-hydroxypyrimido[1,2-a]indoles was investigated. Relative potencies of a number of the most active compounds were defined by three-point dose-response studies. The most potent compounds were those with either 3,3-dimethyl substituents, compounds 21, 22, and 38, or 3,3-spirocyclohexane substituents, compounds 39 and 49. 10-Aminopyrimido[1,2-a]indoles were in general less active than the 10-hydroxy analogues, and potency was further decreased by derivatizing the 10-amino group. The most potent 10-amino derivatives were 57 and 58.
Conjugal TOL Transfer from <i>Pseudomonas putida</i> to <i>Pseudomonas aeruginosa</i> : Effects of Restriction Proficiency, Toxicant Exposure, Cell Density Ratios, and Conjugation Detection Method on Observed Transfer Efficiencies (2005)

The effects of restriction proficiency and premating exposure to toxicants on conjugal transfer of the TOL plasmid between Pseudomonas spp. was investigated by examinations of filter matings. A Pseudomonas putida KT2442-derived strain carrying a gfp-tagged variant of the TOL plasmid was used as a donor, and both restriction-deficient (PAO1162N) and -proficient (PAO2002N) Pseudomonas aeruginosa strains were used as recipients. The in situ enumeration of conjugation events allowed us to obtain frequency estimates that were unbiased by transconjugant growth or plasmid retransfer. We observed a strong dependence of the plasmid transfer frequency on the initial donor-to-recipient ratio of surface matings, which invalidated the use of mass action-based plasmid transfer kinetic estimators. Careful control of the initial parental cell densities permitted evaluations of the true effects of restriction proficiency and toxicant exposure on TOL transfer. At standard donor-to-recipient ratios (10(-3) for PAO1162N and 2 x 10(1) for PAO2002N) and total cell densities (10(5) cells/mm(2) for PAO1162N and 10(6) cells/mm(2) for PAO2002N), plasmid transfer frequencies without toxicant exposure were approximately 10(-7) (events/mm(2))(-1) for PAO1162N and 10(-11) (events/mm(2))(-1) for PAO2002N based on in situ observations of conjugation events. The enumeration of transconjugants via selective plating yielded transfer frequencies that were up to 1 order of magnitude lower. Premating exposure to sodium dodecyl sulfate (1 to 10 mM) significantly increased the transfer frequency for the restriction-proficient strain PAO2002N (P < 0.05) but not for the restriction-deficient strain PAO1162N. On the other hand, premating exposure to ethanol, toluene, or phenol had no positive effect on the plasmid transfer frequency. Clearly, restriction proficiency provides a strong barrier to interspecific transfer of the TOL plasmid, and this barrier was only marginally attenuated by recipient exposure to toxicants within the ranges examined.
Autoimmune hemolytic anemia during alpha interferon treatment in nine patients with hematological diseases. (1996)

BACKGROUND. A number of side effects have been observed in patients treated for hematological diseases with alpha-interferon (IFN). In several cases side effects consisted of immunological disorders. Autoimmune hemolytic anemia (AIHA) is the most typical example of an IFN-induced immune-mediated complication. CASE SERIES. In 10 years we observed 9 patients with various hematological disorders who developed AIHA during IFN treatment. The interval between the start of IFN treatment and the onset of acute hemolysis suggests a dual pattern of occurrence: (1) early onset (interval 1 to 21 days), seen in patients who had anti-RBC antibodies before IFN treatment; (2) late onset (interval 3-38 months), in patients with no history of anti-RBC antibodies at the start of treatment. Discontinuation of IFN, often associated with prednisone treatment, caused prompt hematological recovery in all cases; anti-erythrocyte antibodies persisted in the first group of patients and disappeared in the second. CONCLUSIONS. In rare cases IFN may cause AIHA. The immunological derangement caused by IFN seems to act at two different levels: enhanced destruction of antibody-coated RBCs and induction of autoreactive B-cells. As for the possibility of other preexisting immunological disorders, AIHA (even latent) is a contraindication to IFN treatment. Patients treated with IFN need accurate monitoring to guard against for the development of autoimmune disorders.
Classification with asymmetric label noise: Consistency and maximal denoising (2013)

In many real-world classification problems, the labels of training examples are randomly corrupted. Thus, the set of training examples for each class is contaminated by examples of the other class. Previous theoretical work on this problem assumes that the two classes are separable, that the label noise is independent of the true class label, or that the noise proportions for each class are known. We introduce a general framework for classification with label noise that eliminates these assumptions. Instead, we give assumptions ensuring identifiability and the existence of a consistent estimator of the optimal risk, with associated estimation strategies. For any arbitrary pair of contaminated distributions, there is a unique pair of non-contaminated distributions satisfying the proposed assumptions, and we argue that this solution corresponds in a certain sense to maximal denoising. In particular, we find that learning in the presence of label noise is possible even when the class-conditional distributions overlap and the label noise is not symmetric. A key to our approach is a universally consistent estimator of the maximal proportion of one distribution that is present in another, a problem we refer to as “mixture proportion estimation. ” This work
Elevated ramification of arterial brachialis and its quantifiable impact (2019)

Introduction: Knowledge of variations play significant role in medical sciences and surgical outcome. Discrepancy of arterial Brachialis should be known and kept in mind of radiologists, surgeons during surgical procedures, reconstructive surgeries, measuring blood pressure. So to prevent any accidental detriment, cognizance and scrutiny of anatomical variation is very important. Materials and Methods: Prevalent engagement was carried out on 12 upper limbs of 6 cadavers, during dissection in Branch of Anatomy, AIIMS Rishikesh, independent of age and sex. All dissections was done as per Cunningham handy guidebook of Anatomy, during dissection for undergraduate students. Variations were observed and noted. Observation and Result: Arm length varied from 29 to 35 cm on right or left side. Branching pattern was uniform in (100 per cent cases) of left arm, arterial Brachialis was splitted in Radial and Ulnar artery in cubital fossa. But in right limb 4 (66.70 per cent) constrains of divarication was in cubital-fossa, 1(16.70 per cent) in middle third arm and 1 (16.70 per cent) cases in upper third arm directed to the acromian process. Conclusion: We noted that disparity in arterial brachialis is frequent. There is no compelling association between arm- magnitude and the level of Arterial brachialis partition. Association of Anatomical disparity in branching outline of arterial Brachialis is vital to avert unintended injury to blood vessel during any interventional clinical procedure. Keywords: Arterial brachialis, Cubital fossa, Bifurcation, Arm, Cadaver.
Non-collision Hash Scheme Using Bloom Filter and CAM (2009)

Hash tables are fundamental components of several network processing algorithms and applications, including route lookup, intrusion detection, viruses, worms and other malicious code detection and filtering. Collisions exist in common hash tables, which can critically affect the worst-case throughput of an application, since the number of memory accesses required for each lookup can vary. A non-collision hash scheme was presented, assuring at most one memory access for each lookup. Using Bloom filter (BF) and CAM, this new algorithm is flexible and items can be inserted or deleted quickly. Through a combination of analysis and simulations we show that our algorithm achieves better worst-case performance than the BF based hash table using the same amount of memory and a small amount of additional CAM.
Optimization of planform and cruise conditions of a transport flying wing (2010)

The flying wing is a promising concept for the mid long-term commercial aviation. After the previously published conceptual design of a 300-seat class flying wing, the present article carries out a parametric analysis to optimize its planform and analyse the suitable cruise conditions to achieve the highest efficiency of such configuration. The figures of merit chosen for the optimization are the direct operating cost and the maximum take-off weight per passenger, for a specified constant range of 10 000 km. The design has to respect five relevant constraints: wingspan (limited to 80 m), cabin width, wing tip chord, number of passengers, and cruise lift coefficient. The optimum aircraft fulfilling all constraints cruises at 45 000–47 000 ft and M = 0.82, has an aspect ratio of 6.3 and taper ratio of 0.10, and carries about 280 passengers in three-class seating. This aircraft is about 20 per cent more efficient than conventional wide bodies of similar size, in terms of trip fuel.
Evaluation of Antiviral Activity of Chromane Diols and their Synthetic Analogues (1997)

Two series of functionalized chromanols have been evaluated for antiviral activity. A novel route to 2, 2, 3-trimethylchromane-3, 4-diols is also reported. Chromane-3, 4-diols and chromane-2, 3-diols were found to be active against poliovirus. The best activity against poliovirus was obtained when polar groups, such as OH at position C-6 or CHO at position C-4, were present. Substitution of C-6 with a methoxy group, and especially with a benzyloxy group, enhanced activity against herpes simplex virus 1 (HSV-1). Chromane-2, 3-diols were ineffective against HSV-1.
Lipoprotein-associated phospholipase A<sub>2</sub>: a target directed at the atherosclerotic plaque (2002)

AbstractLipoprotein-associated phospholipase A2 (Lp-PLA2)is so named because it is found in human plasma largely associated with low-density lipoprotein (LDL). It is secreted by macrophages and able to hydrolyse oxidised fatty acids from oxidised phospholipids in LDL thereby releasing pro-atherogenic lysophosphatidylcholine and fatty acids. Inhibition of this enzyme activity was proposed to be antiatherogenic and this hypothesis has been confirmed both in vitro and in animal studies using specific inhibitors. In addition, the enzyme has been shown to be present in human atherosclerotic plaques and to be a potential risk factor for coronary heart disease in epidemiological studies. However, Lp-PLA2 is identical to platelet-activating factor acetylhydrolase (PAF-AH), whose activity is regarded as antiatherogenic. The role of this enzyme in humans, represented as Lp-PLA2 or PAF-AH, remains to be clarified. Specific and potent inhibitors of Lp-PLA2 have been described and help address this question. This is a novel approach directed specifically towards processes in atherogenesis which take place in the artery wall. Innovative strategies for clinical development are required to progress novel molecular strategies such as this.Keywordsatherosclerosisatherosclerotic plaqueC-reactive proteininhibitorslysophosphatidylcholinephospholipaseplatelet-activating factor acetylhydrolaseWOSCOPS
Towards a User-aware Enrichment of Multimedia Metadata (2010)

International audience
Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model (2016)

NB001 may serve as a novel analgesic to treat bone cancer pain. Its analgesic effect is at least partially due to the inhibition of AC1 in anterior cingulate cortex.
Serverless Computing: Applications, Implementation, and Performance (2022)

Following the lead of AWS Lambda, services such as Azure Functions, Google Cloud Functions, Apache OpenWhisk, Iron.io IronFunctions, and OpenLambda have emerged as a new cloud offering coined 'serverless computing', where application logic is split into functions and executed in response to events. In this work, I detail real world applications utilizing these platforms, and explore how existing applications can be adapted to run in serverless environments. Additionally, I present the design of a novel performance-oriented serverless computing platform implemented in .NET, deployed in Microsoft Azure, and utilizing Windows containers as function execution environments. Metrics are proposed to evaluate the execution performance of serverless platforms and conduct tests on the prototype as well as existing commercial platforms. These measurements show the prototype achieving greater throughput than other platforms at most concurrency levels, and I examine the scaling and instance expiration trends in the implementations.
Histopathologic Pattern Analysis of Human Intracutaneous Tuberculin Reaction (1989)

The involvement of cellular immune reactions in the pathogenesis of many inflammatory dermatoses can be postulated from their histopathologic features, e.g., those dermatoses that show a perivascular lymphohistiocytic infiltration in the dermis in addition to their own characteristic epidermal changes. Several granulomatous dermatoses further show an additional infiltration of epithelioid cells. However, experimental production of similar changes is usually not feasible in animals. A human model is needed of delayed-hypersensitivity skin reaction induced by a definite antigen. After closely observing the histopathologic changes of the skin reactions to the purified protein derivative (PPD) of tuberculin, we noted that all patients did not show uniform histologic patterns at intradermal PPD injection sites. Therefore, we have tentatively analyzed histopathologically the pattern of tuberculin skin reactions at injection sites 48 h to 1 year after injection in eight healthy volunteers and 63 patients with various dermatoses. We classified the reactions at 48 h into three types, based on the extent of the tissue damage (i.e., their resemblance to features noted in corresponding inflammatory dermatoses): (a) the perivascular dermatitis type, (b) the basal spongiotic dermatitis type, and (c) the erythema multiforme type. There was a clear correlation between the magnitude of macroscopic skin reactions and these histopathologic patterns. Even those with clinically negative reactions showed a reaction pattern of perivascular dermatitis, whereas those who clinically developed prominent inflammatory reactions with blister formation always showed a erythema multiforme-like histologic pattern. Interestingly, in more than half of the cases, the dermal cellular infiltrate had a mixture of various numbers of neutrophils in addition to mononuclear cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Navigating the great indoors (2012)

Google, dumped by Apple as the iPhone's default navigation app, is doing more than chortling at Apple's well-documented mapping troubles. It's fighting back with more navigation features, many likely intended for use indoors. And a number of major mobile device makers and cellphone service providers have teamed up to develop a standard for indoor navigation, an effort that neither Google nor Apple is part of.
Molecular imaging of cell death in intracardiac tumours: A new approach to differential diagnosis in cardiac tumours. (2002)

This novel imaging technique, molecular imaging, may be of help to differentiate non-invasively between a malignant and benignant primary intracardiac tumour.
Electrical modelling of lossy on-chip multilevel interconnecting lines (1991)

A self contained method for the electrical modelling of lossy 3-D multilevel interconnections has been developed. The method allows for the generation of a multiple coupled line model, compatible with SPICE-like CAD programs, from the interconnection line constants and parasitic coupling parameters which are computed by the so-called method of moments. The proposed method can be used for the analysis of coupled line systems with linear or nonlinear/time varying terminators, as well as for the study of the pulse propagation characteristics in high-speed ICs. Numerical results are presented for 3-D parallel and galvanically separated crossed planar lines. >
Best practices for applying air ionization (1995)

Air ionizers are used throughout the semiconductor manufacturing process to control ESD and contamination. This papers reviews the "best practices" in applying ionizers in front-end and back-end applications in the semiconductor industry. Uses of room ionizers in cleanrooms, and point-of-use ionizers in production equipment will be discussed.
The Gilles de la Tourette Syndrome: the Current Status (1989)

The Gilles de la Tourette Syndrome is a movement disorder characterised by both motor and vocal (phonic) tics. It was once thought to be rare, and the literature until the 1970s consisted predominantly of case reports, both highlighting the fascinating clinical manifestations and speculating as to their aetiology. Many areas of GTS are under investigation, including the neurology, psychopathology, neurophysiology, biochemistry, and genetics. This review briefly considers early descriptions of GTS as well as current research, highlighting the areas of agreement and controversy.