gebhart/patrepeval huggingface dataset:
Lamotrigine‐Induced Blepharospasm (1999)

Movement disorders such as tremor and ataxia occur commonly during therapy with antiepileptic drugs (AEDs). Dystonias, however, are rare. Blepharospasm, although reported with neuroleptic agents, has never been reported with AEDs. Our patient developed blepharospasm during therapy with lamotrigine.
SIGNALING BY EXTRACELLULAR NUCLEOTIDES (1996)

ATP and other nucleotides can be released from cells through regulated pathways, or following the loss of plasma membrane integrity. Once outside the cell, these compounds take on new roles as intercellular signaling molecules that elicit a broad spectrum of physiological responses through the activation of numerous cell surface receptor subtypes. This review summarizes recent advances in the molecular characterization of ATP receptors and discusses roles for cloned receptors in established and novel physiological processes.
Roll Control for a Micro Air Vehicle Using Active Wing Morphing (2003)

A micro air vehicle is a ight system being designed for operation within urban environments. Such vehicles are small and highly agile but often have limited control authority. This paper investigates the use of morphing as an effector to provide control authority. Simple mechanisms for morphing are designed to twist the wings of a 24 in vehicle and to curl the wings of a 12 in vehicle. Flight tests show the morphing is an excellent strategy to command roll maneuvers. The resulting vehicles are relatively easy to y and consequently are suitable for autopilot design and mission deployment.
Analysis of Laterally Loaded Piles in Sand (1974)

Abstract Data were taken during the lateral loading of two 24-in. diameter test piles installed at a site where the soils consisted of clean fine sand to silty fine sand. Two types of loading were employed, static loading and cyclic loading. The data were analyzed and families of curves were developed which showed the soil resistance p as a function of pile deflection y. With theoretical studies as a basis, a method was devised for predicting the family of p-y curves based on the properties of sand and pile dimension. Procedures are suggested or both static loading and cyclic loading. While there is some basis for the methods from theory, the behavior of sand around a laterally loaded pile does not yield to a completely rational analysis; therefore, a considerable amount of empiricism is involved in the recommendations. The procedure was employed for predicting p-y curves at the experimental sire and computed results are compared with experimental results. The agreement is good. Foreword This paper is a companion to the paper entitled, "Field Testing of Laterally Loaded Piles in Sand," by William R. Cox, Lymon C. Reese and Berry R. Grubbs. The research described in fund set up by the following oil companies: Amoco Production Company, Chevron Oil Field Research, Esso Production Research Company, Mobil Oil Corporation, and Shell Development Company. Shell Development Company was the operator of the project. Introduction There are a relatively small number of papers in the technical literature which give recommendations for predicting the behavior of the soil around the piles subjected to lateral loading. With regard to sand, such recommendations are made in two papers, Terzaghi1 and Parker and Reese.2 Terzaghi presents no experimental evidence for the parameters which he recommends; the paper by Parker and Reese is based on lateral load tests of small diameter piles. The method presented below is based on the results of full-scale tests of instrumented piles and should be a useful addition to the literature. The differential equation, Eq.1, for the problem of the laterally loaded pile is well known and its solution has been discussed by a number of authors. 3,4,5,6,7 (Mathematical Equation Available in Full Paper) It should be noted that Eq. 1 does not include a term to account for the effect of axial load on bending. If the axial load is sizable, Eq. 1 should be expanded. As indicated in the referenced papers, appropriate solutions can sometimes be obtained by the use of non-dimensional relationships. A more favorable approach is to write the differential equation in difference form and to obtain solutions by use of the digital computer. In the solution of the differential equation, appropriate boundary conditions must be selected at the top of the pile to insure that the equations of equilibrium and of compatibility are satisfied at the interface between the pile and the superstructure. The selection of the boundary conditions is a simple problem in some instances; for examples, where the superstructure is simply a continuation of the pile.
Exonuclease III protection assay with FRET probe for detecting DNA-binding proteins (2005)

We describe a new method for the assay of sequence-specific DNA-binding proteins in this paper. In this method, the sensitive fluorescence resonance energy transfer (FRET) technology is combined with the common DNA footprinting assay in order to develop a simple, rapid and high-throughput approach for quantitatively detecting the sequence-specific DNA-binding proteins. We named this method as exonuclease III (ExoIII) protection assay with FRET probe. The FRET probe used in this assay was a duplex DNA which was designed to contain one FRET pair in the center and two flanking protein-binding sites. During protein detection, if a target protein exists, it will bind to the two protein-binding sites of the FRET probe and thus protect the FRET pair from ExoIII digestion, resulting in high FRET. However, if the target protein does not exist, the FRET pair on the naked FRET probe will be degraded by ExoIII, resulting in low FRET. Three kinds of recombinant transcription factors including NF-kappaB, SP1 and p50, and the target protein of NF-kappaB in HeLa cell nuclear extracts, were successfully detected by the assay. This assay can be extensively used in biomedical research targeted at DNA-binding proteins.
SYSTEM EVALUATION FROM IMPULSE RESPONSE FRAGMENTS (1972)

Statistical estimation or identification procedures often describe a dynamical systemby its sampled impulse response. This is not always useful or desirable for further dataprocessing. It is largely necessary to provide information on the z- or s- transfer functionof the system. As an additional hardship, the impulse response is sometimes known only overa limited time interval because of an insignificantly damped system or a limited computercapacity. By use of rational approximation, a procedure has been found which allows calcula-tion of the z-transfer function from a restricted number of time sequence values. The orderof the system need not be known. Transformation to the s-domain is easily provided.
Towards the evaluation of force-sensing resistors for in situ measurement of interface pressure during leg compression therapy (2016)

While compression therapy is the cornerstone in managing leg venous disorders, the applied pressure has to be in specific ranges in order to have an effective treatment. Medical bandages and compression stockings lack an embedded pressure measurement system. The listed class of compression for medical stockings is not utterly reliable, and achieving desired pressure profiles in medical bandages is dependent solely on the bandaging skills of clinicians. Moreover, after the recipients of compression products leave medical centers, there exists no way to continuously assess the changes in sub-bandage pressure that might occur due to movements and physiological changes of the lower extremities. Thus there is a need for a valid and reliable measurement system that can be integrated into compression products for continuous monitoring of the interface pressure. In the current study, force-sensing resistors (FSRs®), which are portable, thin, flexible, low-cost, and easy-to-use sensors, were investigated. FSRs, like many other flexible resistive sensors, are known for their qualitative rather than quantitative measurements. Therefore, they should be validated for clinical use. In this study, the FSRs were first calibrated on different surfaces, including human leg, and then evaluated in measuring interface pressures in situ. The preliminary investigations showed promising results.
Context aware service provisioning (2004)

We present our initiative on a new direction of research for bringing into the common fold context-aware computing and Web services-oriented computing. Our long term research objective is to allow users to satisfy their needs regardless of their location and the resources that are considered in the performance of the sendees. Our contribution is the enhancement of the service discovery and composition by taking into account the available contextual information. As a first step towards this goal we are in the process of designing a new service description based on context.
GaN Gate Injection Transistor with integrated Si Schottky barrier diode for highly efficient DC-DC converters (2012)

In this paper, we present a novel GaN-based normally-off transistor with an integrated Si Schottky barrier diode (SBD) for low voltage DC-DC converters. The integrated SBD is formed by the Si substrate for the epitaxial growth of AlGaN/GaN hetero-structure, which is connected to the normally-off GaN Gate Injection Transistor (GIT) over it with via-holes. The diode can flow the reverse current in the conversion operation with lower forward voltage than that of the lateral GaN transistor enabling lower operating loss. A DC-DC converter from 12V down to 1.3V using the integrated devices with the reduced gate length down to 0.5μm exhibits a high peak efficiency of 89% at 2MHz demonstrating the promising potential of GaN devices for the application.
MODELO DE PREVISÃO POR SÉRIES TEMPORAIS: UMA APLICAÇÃO PARA SERVIÇOS COMERCIAIS EM UMA CONCESSIONÁRIA DE ENERGIA ELÉTRICA (2019)

O presente trabalho analisa o atendimento da demanda das ordens de servico comercial de uma empresa que fornece energia eletrica para uma regiao do estado do Rio Grande do Sul. O objetivo e prever o tempo de servico demandando, para auxiliar no despacho das ordens para as equipes de manutencao, com base nos dados historicos de demanda de tempo de servico do ano anterior, buscando reduzir o tempo de espera para cliente em funcao da energia interrompida ate a solucao do problema pela equipe. Para prever o tempo de servico foram aplicados tres metodos de previsao de demanda quantitativos, baseados em series temporais, sendo eles o metodo de suavizacao exponencial simples, suavizacao de Holt e suavizacao de Winter. Os dados foram agrupados por dia da semana, de acordo com o estudo da correlacao realizado, e apos, foram avaliados os metodos. Com base nos erros encontrados, foi definido que o metodo mais adequado era suavizacao de Holt, sendo confirmado atraves da analise do sinal de acompanhamento.
Low Energy Desalination Using Battery Electrode Deionization (2017)

New electrochemical technologies that use capacitive or battery electrodes are being developed to minimize energy requirements for desalinating brackish waters. When a pair of electrodes is charged in capacitive deionization (CDI) systems, cations bind to the cathode and anions bind to the anode, but high applied voltages (>1.2 V) result in parasitic reactions and irreversible electrode oxidation. In the battery electrode deionization (BDI) system developed here, two identical copper hexacyanoferrate (CuHCF) battery electrodes were used that release and bind cations, with anion separation occurring via an anion exchange membrane. The system used an applied voltage of 0.6 V, which avoided parasitic reactions, achieved high electrode desalination capacities (up to 100 mg-NaCl/g-electrode, 50 mM NaCl influent), and consumed less energy than CDI. Simultaneous production of desalinated and concentrated solutions in two channels avoided a two-cycle approach needed for CDI. Stacking additional membranes between CuHCF electrodes (up to three anion and two cation exchange membranes) reduced energy consumption to only 0.02 kWh/m3 (approximately an order of magnitude lower than values reported for CDI), for an influent desalination similar to CDI (25 mM decreased to 17 mM). These results show that BDI could be effective as a very low energy method for brackish water desalination.
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis (2015)

Our data support the novel concept of glycolytic reprogramming in the pathogenesis of lung fibrosis and provide proof-of-concept that targeting this pathway may be efficacious in treating fibrotic disorders, such as idiopathic pulmonary fibrosis.
Guidelines for Healthy Weight (1999)

Excess body fat is a cause of cardiovascular diseases, several important cancers, and numerous other medical conditions1 and is a growing problem in many countries. In the United States, for example, the age-adjusted prevalence of obesity increased by approximately 30 percent from 1980 to 1994.2 In this review we consider the assessment of body fat and the definition of a healthy body weight for an adult. We also discuss how clinicians can use this information in caring for patients. Because overt obesity has undisputed adverse consequences for health, our focus is on lesser degrees of adiposity, the consequences of which . . .
Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study (2004)

Topical immunotherapy exerts an important role in angiogenesis, upregulating VEGF in human hair follicle keratinocytes and upregulating survivin to preserve endothelial cell viability. Moreover, it considerably alters the peribulbar CD4/CD8 ratio, restoring a condition close to normal scalp skin. Our study could contribute to explaining some aspects of AA pathogenesis that are still unknown and aid understanding of how DPC could act in this complex disease.
Hexafluoroacetone ketals as derivatives for positional and geometrical characterization of double bonds (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexafluoroacetone ketals as derivatives for positional and geometrical characterization of double bondsBruce M. Johnson and James W. TaylorCite this: Anal. Chem. 1972, 44, 8, 1438–1444Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/ac60316a024https://doi.org/10.1021/ac60316a024research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Toxicity of Adjuvant Endocrine Therapy in Postmenopausal Breast Cancer Patients: A Systematic Review and Meta-analysis (2011)

The cumulative toxicity of aromatase inhibitors when used as up-front treatment may explain the lack of overall survival benefit despite improvements in disease-free survival. Switching from tamoxifen to aromatase inhibitors reduces this toxicity and is likely the best balance between efficacy and toxicity.
Modified Extraction 2-Thiobarbituric Acid Method for Measuring Lipid Oxidation in Poultry (1987)

A simple and accurate objective test for monitoring lipid oxidation in poultry products is needed. Thiobarbituric acid (TBA) values of cooked poultry meat were determined by a distillation method and by a modified extraction method. Perchloric acid was used in the extraction method to release TBA reactive substances from the meat. The maximum absorption wavelength of the TBA-malonaldehyde complex was 531 nm. The TBA values for cooked chicken and turkey were highly correlated (r = .91) for both the extraction and distillation methods. Sensory scores of warmed-over flavor in precooked poultry were highly correlated with TBA values in both the distillation (r = .83) and extraction (r = .85) methods. Results indicate that the extraction method is faster, easier to perform, and as accurate as the distillation method for monitoring lipid oxidation in poultry.
Influence of Electrode Surface Conditions on the Electrical Strength of Liquified Gases (1960)

The strengths of liquified argon, oxygen and nitrogen are of the order of 1 mv/cm but are found to depend to a marked degree on the nature of the electrode surfaces. The strength can be changed in a regular manner (sometimes by as much as 50%) by changing both the electrode metal and the degree of surface oxidation. The important discovery is that the anode as well as the cathode has a strong influence on the strength. This surprising result has, as yet, no obvious explanation in terms of usual breakdown mechanisms but may be very significant, not only for theories of breakdown in these liquids but for hydrocarbon liquids as well.
Quantitative Genetic Analysis of Growth Rate in Lisianthus (1993)

Abstract A study was made of the inheritance of stem elongation rate during early (SER1) and late (SER2) vegetative growth period, of mean leaf width (MLW) and of days to flowering (DTP) in lisianthus ( Eustoma grandiflorum Shinn.). The analysis was based on the data of an F1 diallel cross between different breeding lines. Marked directional heterosis was found for SER1, SER2 and MLW, but not for DTF, in which the dominance effects were incomplete and non‐directional. SER1 and SER2 were positively correlated with MLW, but negatively correlated with DTP. The implications and the potential of heterotic growth rate of F1 hybrid lisianthus are discussed.
Radiolabeled peptides for targeting cholecystokinin-B/gastrin receptor-expressing tumors. (1999)

CCK/gastrin analogs may be a useful new class of receptor-binding peptides for diagnosis and therapy of CCK-B receptor-expressing tumors, such as MTC or small cell lung cancer. Nonsulfated gastrin derivatives may be preferable because of their CCK-B receptor selectivity, hence lower accretion in normal CCK-A receptor-expressing organs.
Clamping Force Estimation for a Brake-by-Wire Actuator (1999)

<div class="htmlview paragraph">In the scope of a research collaboration, Continental Teves (formerly ITT Automotive Europe) and Darmstadt University of Technology are developing control strategies for a low-cost Brake-by-Wire system, using no clamping-force or brake-torque sensor as feedback [<span class="xref">1</span>]. However, since there is a wide range of variation in the efficiency of the gear units used in electromechanical brakes, this becomes a demanding task.</div> <div class="htmlview paragraph">The paper first describes the assembly and operation of Continental Teves' third generation brake actuator, which is still operated using an integrated clamping force sensor [<span class="xref">2</span>]. It introduces the development environment of Darmstadt University of Technology, consisting of a brake test stand, a complex brake actuator model, and a simplified brake actuator model. A detailed analysis of the motor rotor position and the motor current, both signals that are already available from the brake, discusses their advantages and disadvantages with regard to a possible use for clamping force estimation.</div> <div class="htmlview paragraph">Based on the simplified brake model and the signal analysis, an algorithm to reconstruct the clamping force from the motor rotor position and the motor current only is introduced. To adjust the clearance without a force sensor, a strategy to detect the contact point between the brake pads and the brake disk is developed.</div> <div class="htmlview paragraph">First experimental results of the clamping force estimation and the clearance management are shown.</div>
Range and mean distribution frequency of individual tooth width of the maxillary anterior dentition. (2007)

This article will discuss the clinical significance of tooth biometry and distribution frequency, in which size for tooth restoration may vary among patients of different age, race, or sex. Upon reading this article, the reader should: Become more familiar with the range of individual tooth width of the maxillary anterior dentition and their mean distribution frequencies. Understand that gender differences may exist affecting the width of maxillary anterior teeth.
Therapeutic Monitoring of Aripiprazole by HPLC with Column-Switching and Spectrophotometric Detection (2005)

Aripiprazole is a novel atypical antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders (1)(2)(3). The drug is metabolized by the cytochrome P450 isoenzymes 3A4 and 2D6 (4). Because of high interindividual variability in the expression of these enzymes, the aripiprazole concentration varies among healthy individuals after administration of the drug (5). In patients, insufficient response or side effects, such as somnolence, akathisia, or nausea, may result from too low or too high drug concentrations. Therapeutic drug monitoring (TDM), which is established practice for many antipsychotic drugs (6)(7), may be helpful for patients treated with aripiprazole. We measured aripiprazole by HPLC with column-switching and ultraviolet detection, based on a previously reported method for TDM of the antidepressant reboxetine (8).

Pure drug was not available; we therefore incubated tablets containing 15 mg of aripiprazole base (Abilify®; Bristol-Myers Squibb/Otsuka Pharmaceuticals) for several days in the dark at room temperature in 15 mL per tablet of methanol (LiChrosolve; Merck) or ultrapure water adjusted to pH 2 with 0.1 mol/L HCl. Before chromatographic analysis, suspensions were shaken and cleared by centrifugation (3000 g for 5 min). Maximum solution was attained within the first 24 h. Because the mean drug concentrations in samples diluted to concentrations of 100, 200, or 500 μg/L differed little (2.7%; range, −7% to 10%) between methanol and water solutions, complete solution by methanol was assumed. Methanolic solutions were used for the preparation of calibrator samples with 6 concentrations between 50 and 500 μg/L and quality-control samples containing 50, 250, or 400 μg/L, prepared by supplementing drug-free plasma with aripiprazole. Perphenazine base from Sigma was used as internal standard in a final concentration of 0.0615 g/L.

Blood for serum preparation was collected from 27 schizophrenic patients who had been treated with aripiprazole. The …