gebhart/patrepeval huggingface dataset:
Inactivation of Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke and Phagocyte-Derived Oxidants (1980)

Freshly prepared aqueous solutions of cigarette smoke suppressed the elastase inhibitory capacity (EIC) of the acid-stable proteinase inhibitor present in bronchial mucus (BMPi) and human seminal plasma (HUSI-I). Thin-layer gel-immunofiltration analysis of mixtures of smoke-treated BMPi and human leukocyte elastase showed decreased elastase: BMPi complexes, increased uncomplexed BMPi and increased free elastase. Phenolic antioxidants prevented the suppression of the EIC of BMPi or HUSI-I by cigarette smoke. In addition, treatment of BMPi or HUSI-I with chemical oxidants caused a similar suppression of EIC. Furthermore, treatment of BMPi or HUSI-I with the phagocyte-derived oxidizing system, myeloperoxidase + H2O2 + Cl-, suppressed EIC. Finally, the functional activity of BMPi was significantly reduced in tracheal aspirates of human smokers compared to that of nonsmokers. These results support the hypothesis that local inactivation of BMPi in the conducting airways of the lung by inhaled cigarette smoke or by phagocyte-derived oxidants may play a role in the pathogenesis of obstructive lung disease in smokers.
New Synthesis of Isoprene Based on Formaldehyde and Isobutylene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Synthesis of Isoprene Based on Formaldehyde and IsobutyleneDavid W. Hall, Frank L. Dormish, and Edward Hurley Jr.Cite this: Ind. Eng. Chem. Prod. Res. Dev. 1970, 9, 2, 234–242Publication Date (Print):June 1, 1970Publication History Published online1 May 2002Published inissue 1 June 1970https://doi.org/10.1021/i360034a023Request reuse permissionsArticle Views383Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts
Helical CT of the Body (2001)

Pediatric helical CT parameters are not adjusted on the basis of the examination type or the age of the child. In particular, these results suggest that pediatric patients may be exposed to an unnecessarily high radiation dose during body CT.
GaAs FET power amplifier module with high efficiency (1983)

A high-efficiency GaAs FET power amplifier having a total efficiency of 70% and an output power of 2 W is realised in the 900 MHz band. A drain efficiency of 80% was achieved at a low operation voltage of 6 V. These high efficiencies were obtained by using the even-order harmonic tuning of an output matching circuit. Important parameters for achieving this efficiency are also clarified.
Dynamic channel allocation schemes in mobile radio systems with frequency hopping (2002)

In this paper a F-TDMA based mobile radio system using both dynamic channel allocation (DCA) and frequency hopping (FH) is investigated. We propose and evaluate the performance of a new interference adaptive DCA (IA-DCA) algorithm that is suitably designed for a network implementing FH. The results we show in the paper have been achieved by means of a simulation tool which takes propagation, mobility, interference, traffic and channel allocation into account. Moreover, the advantages of using FH are accounted for by using suitable analytical models that give the frame error rate as a function of the carrier-to-interference ratio and the number of hopping frequencies. We compare the performance of our proposal to that of fixed channel allocation (FCA) with and without FH, and the well known IA-DCA schemes investigated in the literature in the absence of FH. The performance results show that interesting synergic effects can be obtained in terms of forced termination and user satisfaction probability by using both DCA and FH in a F-TDMA based mobile radio network.
Synthesis of α-Helices Having a Positively Charged Random Coil-Block on Either N- or C-Terminal (1988)

Abstract To study a charge-induced stabilization of α-helix, α-helical peptides having a positively charged random-coil block on either N- or C-terminal of the helix, and having a strictly defined length, (Ala)20(X)20Phe and (X)20(Ala)20Phe (X=Lys or Orn), were synthesized. Component dipeptides were coupled on p-(oxymethyl)phenylacetamidomethyl polystyrene.
Whole world of pattern (2013)

Hilary White concludes her series on pattern by looking at the natural world. Exotic animals and those found closer to home, objects in the setting and even groups of people can provide artistic inspiration.
Synthesis of pro-apoptotic indapamide derivatives as anticancer agents (2015)

4-Chloro-3-({[(substitutedamino)carbonothioyl]amino}sulfonyl)-N-(2-methyl-2,3-dihydro-1H-indole-1-yl)benzamide (1-20) and 4-chloro-3-({[3-(substituted)-4-oxo-1,3-thiazolidine-2-ylidene]amino}sulfonyl)-N-(2-methyl-2,3-dihydro-1H-indole-1-yl)benzamide derivatives (21-31) were synthesized from 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide (indapamide). 4-Chloro-3-({[(4-chlorophenyl) amino) carbonothioyl]amino}sulfonyl)-N-(2-methyl-2,3-dihydro-1H-indole-1-yl)benzamide 12 demonstrated the highest proapoptotic activity among all synthesized compounds on melanoma cell lines MDA-MB-435 with 3.7% growth inhibition at the concentration of 10 µM. Compound 12 (SGK 266) was evaluated in vitro using the MTT colorimetric method against melanoma cancer cell line MDA-MB435 growth inhibition for different doses and exhibited anticancer activity with IC50 values of 85-95 µM against melanoma cancer cell line MDA-MB435. In addition, this compound was investigated as inhibitors of four physiologically relevant human carbonic anhydrase isoforms, hCA I, II, IX and XII. The compund inhibited these enzymes with IC50 values ranging between 0.72 and 1.60 µM.
Antiinflammatory agents. 1. Synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid (1979)

The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models.
Effective therapy for nephritis in (NZB × NZW)F<sub>1</sub> mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy <i>Tripterygium wilfordii</i> Hook F (2008)

Therapy with triptolide or tripdiolide significantly ameliorated lupus nephritis in (NZB x NZW)F1 mice, reduced cytokine and chemokine production, and prolonged survival.
Tool selection and path planning in 3-axis rough machining (1999)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1999.
Homogeneous Hydrogenation of Methyl Linoleate Catalyzed by Iron Pentacarbonyl. Characterization of Methyl Octadecadienoate—Iron Tricarbonyl Complexes<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous Hydrogenation of Methyl Linoleate Catalyzed by Iron Pentacarbonyl. Characterization of Methyl Octadecadienoate—Iron Tricarbonyl Complexes1E. N. Frankel, E. A. Emken, Helen M. Peters, V. L. Davison, and R. O. ButterfieldCite this: J. Org. Chem. 1964, 29, 11, 3292–3297Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/jo01034a040https://doi.org/10.1021/jo01034a040research-articleACS PublicationsRequest reuse permissionsArticle Views384Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Differential Localization of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 and CD47 and Its Molecular Mechanisms in Cultured Hippocampal Neurons (2005)

Polarized localization of membrane proteins to axons or dendrites is important for a variety of neuronal functions, including neurite outgrowth and synaptogenesis during neural development. Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) and its ligand cluster of differentiation 47 (CD47), both of which are members of the Ig superfamily of proteins, are thought to constitute an intercellular communication system in the CNS, although the physiological functions of this CD47-SHPS-1 system remain unknown. To provide insight into these functions, we have now examined the localization of SHPS-1 and CD47 in cultured hippocampal neurons. Endogenous SHPS-1 was detected at the surface of both axons and dendrites, whereas endogenous CD47 was localized predominantly to the surface of dendrites. Forced expression of these two proteins confirmed their distinct localizations. The extracellular regions of SHPS-1 and CD47 were responsible, at least in part, for their axonal and dendritic localizations, respectively; however, the axonal localization of SHPS-1 was not mediated by any one of the three Ig domains in its extracellular region. Overexpression of SHPS-1 and CD47 in distinct neurons resulted in marked accumulation of these proteins at sites of contact between SHPS-1-expressing axons and CD47-expressing dendrites. Such contact sites exhibited an enlarged structure but did not contain the synaptic marker protein vesicle-associated membrane protein-2. These results suggest that differential localization of SHPS-1 and CD47 at axons and dendrites generates a directional intercellular communication system that potentially contributes to regulation of synaptogenesis and the formation of neural networks.
Acute lymphoblastic leukemia: Treatment (1978)

Over the past thirty years, major progress has been achieved in the treatment of ALL. Many of the concepts, definitions, and principles of chemotherapy have and continue to be derived from studies in ALL. Major and continuing progress is ongoing for the various categories of treatment; that is, remission induction, treatment at sites of high risk for relapse (e. g., pharmacologic sanctuaries), cytoreductive therapy during complete remission, and duration of treatment. Rapid improvement in our understanding of the pathogenesis of ALL and particularly the identification of immunologic and prognostic subcategories of ALL have major therapeutic implications which are in process of being realized. Current research is focused on the development of new chemotherapeutic agents, the more rational basis for the employment of chemotherapeutic agents in combination (cytokinetic, pharmacologic, and related studies), a better definition of the host-tumor relationship particularly with respect to immunologic response and iatrogenic manipulation of such responses, and in the area of supportive care and bone marrow transplantation.
Development of micro inchworm robot actuated by electrostrictive polymer actuator (2001)

In previous works, the possibility of the electrostrictive polymer as the actuator use has been proved. In this paper we address an actual design of an actuator and an inchworm type robotic mechanism using the electrostrictive polymer. The robot will be developed to move horizontally, vertically with steering capability, aiming for navigation in small tubular structures such as flexible pipes but now in this stage a simple bellows type robot capable of accomplishing the linear movement like that of an inchworm is introduced. The issues about the mechanism design of the prototype, which has already been developed and under the consideration of reduction in size, are discussed and preliminary results of experiments are given.
Interrogative reformulation patterns and acquisition of question paraphrases (2003)

We describe a set of paraphrase patterns for questions which we derived from a corpus of questions, and report the result of using them in the automatic recognition of question paraphrases. The aim of our paraphrase patterns is to factor out different syntactic variations of interrogative words, since the interrogative part of a question adds a syntactic superstructure on the sentence part (i.e., the rest of the question), thereby making it difficult for an automatic system to analyze the question. The patterns we derived are rules which map surface syntactic structures to semantic case frames, which serve as the canonical representation of questions. We also describe the process in which we acquired question paraphrases, which we used as the test data. The results obtained by using the patterns in paraphrase recognition were quite promising.
Still image transmission using unequal error protection coding in mobile radio channel (1996)

Abstract With the advent of multimedia mobile communication, image transmission in the fading channel is becoming more and more important. This paper discusses the highly efficient coding where the image coding and the channel coding are integrated. More precisely, the following hierarchical image transmission is proposed. Assuming Joint Photograph Experts Group (JPEG) progressive image coding, discrete cosine transform (DCT) transform coefficients or the bit planes are divided into groups so that the unequal channel coding rates are assigned according to the effect of the channel error on the image quality. The proposed system is examined and evaluated by a computer simulation. As a result, it is shown that the reconstructed image suffers from less deterioration compared to the case where the channel coding rate is assigned uniformly.
Cardiac-induced localized thoracic motion detected by a fiber optic sensing scheme (2014)

The cardiovascular health of the human population is a major concern for medical clinicians, with cardiovascular diseases responsible for 48% of all deaths worldwide, according to the World Health Organization. The development of new diagnostic tools that are practicable and economical to scrutinize the cardiovascular health of humans is a major driver for clinicians. We offer a new technique to obtain seismocardiographic signals up to 54 Hz covering both ballistocardiography (below 20 Hz) and audible heart sounds (20 Hz upward), using a system based on curvature sensors formed from fiber optic long period gratings. This system can visualize the real-time three-dimensional (3-D) mechanical motion of the heart by using the data from the sensing array in conjunction with a bespoke 3-D shape reconstruction algorithm. Visualization is demonstrated by adhering three to four sensors on the outside of the thorax and in close proximity to the apex of the heart; the sensing scheme revealed a complex motion of the heart wall next to the apex region of the heart. The detection scheme is low-cost, portable, easily operated and has the potential for ambulatory applications.
Phase equilibriums in the system calcium phosphate-zinc phosphate (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase equilibriums in the system calcium phosphate-zinc phosphateEric R. Kreidler and Floyd A. HummelCite this: Inorg. Chem. 1967, 6, 3, 524–528Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://doi.org/10.1021/ic50049a021Request reuse permissionsArticle Views205Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (542 KB) Get e-Alertsclose Get e-Alerts
Salt sensitivity. Definition, conception, methodology, and long-term issues. (1991)

Several laboratories have examined the relation between salt intake and blood pressure in both experimental animals and humans. The human studies have used widely varying methodologies and different criteria for sodium sensitivity. Nonetheless, these studies have produced convincing data that the blood pressure of some individuals is far more sensitive to the effects of sodium depletion or loading than that of others. Furthermore, a minority of the population appears to comprise acutely salt-sensitive individuals. Some studies have shown that sodium-sensitive individuals share several characteristics. They include increased forearm vascular resistance, decreased venous compliance, suppressed plasma renin activity, and lower circulating aldosterone concentration. These findings have also been described in the Dahl salt-sensitive rat, which suggest a genetic link in humans as well as the rat. Long-term follow-up of sodium-sensitive and sodium-resistant groups has shown that although blood pressure levels are approximately equal in the two groups during sodium depletion, resumption of a daily sodium intake of about 150 meq results in significantly higher levels of blood pressure and forearm vascular resistance in the sodium-sensitive group. This difference persists for at least 12 months.
A 47 GHz $LC$ Cross-Coupled VCO Employing High-$Q$ Island-Gate Varactor for Phase Noise Reduction (2010)

A 47 GHz <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> cross-coupled voltage controlled oscillator (VCO) employing the high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> island-gate varactor (IGV) based on a 0.13 ¿m RFCMOS technology is reported in this work. To verify the improvement in the phase noise, two otherwise identical VCOs, each with an IGV and a conventional multi-finger varactor, were fabricated and the phase noise performance was compared. With <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VDD</i> of 1.2 V and core power consumption of 3.86 mW, the VCOs with the IGV and the multi-finger varactor have a phase noise of -95.4 dBc/Hz and -91.4 dBc/Hz respectively, at 1 MHz offset, verifying the phase noise reduction with the introduction of the high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> IGV. The VCO with IGV exhibited an output power of around -15 dBm, leading to a FoM of -182.9 dBc/Hz and a tuning range of 3.35% (45.69 to 47.22 GHz).
Effect of Lignocellulosic Substrate and Commercial Cellulase Loading on Reducing Sugar Concentration for Ethanol Production (2012)

Fuel ethanol production from lignocellulosic biomass requires a relatively high initial sugar concentration in hydrolysate. Raising the substrate and enzyme concentration in the batch hydrolysis will normally help to heighten sugar concentration. In this study, dilute sulfuric acid pretreatment was used for chemical pretreatment of rice straw. The effect of rice straw and commercial cellulase (Accelerase 1000 TM ) loading were investigated. It was found that an increase in rice straw from 7.5 to 15.0 g/100 mL H 2 SO 4 raised the reducing sugar concentration from 27.70 1.72 to 58.42 1.23 g/L. At the high level of rice straw up to 20.0 g/100 mL H 2 SO 4 gave a slight increase in reducing sugar of 66.17 0.00 g/L. On the contrary, the rice straw conversion decreased from 343.27 1.29 to 286.22 2.39 mg/g DS (Dry residue substrate) and holocellulose conversion slightly decreased from 47.02 0.18 to 39.21 0.33% (w/w) when the rice straw increased from 15.0 to 20.0 g/100 mL H 2 SO 4 . The reducing sugar concentration increased from 52.98 0.73 g/L to 64.61 0.53 g/L and rice straw conversion changed from 293.44 5.12 to 414.16 0.19 mg/g DS, when the use of Accellerase 1000 TM increased from 10 to 45 FPU/g DS. It also found that the large amount of Accelerase 1000 TM loading (50 and 55 FPU/g DS) did not improve the reducing sugar and rice straw conversion.
The Retinal Image Mosaic Based on Invariant Feature and Hierarchial Transformation Models (2009)

It is important to determine the stable keypoints and select transformation models for image registration and mosaic. In this paper a method is presented for retinal image mosaic. Central to the new method is to detect the PCA-SIFT (principal components analysis-scale invariant feature transform) feature and estimate the quadratic transformation model which is employed to simulate the anatomy of human eyes. The transformations models are estimated by matching PCA-SIFT landmarks. The hierarchical notion is used to map the inter-image. The random sample consensus (RANSAC) is used to estimate the affine transformation model and remove exterior point. The quadratic is estimated by m-estimator. And the weighted mean is used to stitch retinal images. The proposed approach can effectively realize the retinal image mosaic.
PSYCHOLOGICAL MEDICINE (1949)

PSYCHOLOGICAL MEDICINE Get access Introduction to Group-Analytic Psycho-therapy. Studies in the Social Integration of Individuals and Groups S. H. Foulkes. London : William Heinemann Medical Books Ltd., 1948. xiv + 181 pages. 22 × 14 cm. £1 1s. [£1.05] F. Kraupl Taylor F. Kraupl Taylor Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 6, Issue 1-2, 1949, Page 108, https://doi.org/10.1093/oxfordjournals.bmb.a073420 Published: 01 January 1949