gebhart/patrepeval huggingface dataset:
Soundfield navigation: Separation, compression and transmission (2013)

Extracellular matrix metalloproteases are synthesized as proenzymes and are activated by certain physiological agents after secretion into the extracellular space. The identity of these agents and the stimulus that elicits their response in vivo is only recently becoming clear, but a variety of agents or stimuli are capable of activating these metalloproteases in vitro also. Of these, the most well studied and characterized are trypsin, plasmin and the organomercurials. These agents appear to have in common an ability to disrupt the structure of the stable latent enzyme in such a way as to allow the generation of a proteolytic active site. In the case of organomercurial activation, intramolecular proteolytic cleavage of the amino-terminus of the enzyme occurs subsequent to generation of activity. A similar intramolecular process is seen with trypsin and plasmin activation except that it is initiated by a single trypsin or plasmin catalyzed cleavage in the amino-terminus prior to the autocatalytic cleavages. A possible explanation for organomercurial activation is that the mercurial disrupts a cysteinyl residue coordination bond with the active site zinc that prevents interaction with substrate. Disruption of this complex would allow productive enzyme-substrate interaction via the newly available coordination site. In addition, activated stromelysin is capable of increasing the specific activity of active interstitial collagenase by approximately ten-fold through what appears to be proteolytic removal of a small peptide.
Phase locking of adjacent channel leaky waveguide CO2 lasers (1984)

Phase locking has been achieved between two adjacent waveguide CO2 lasers separated by a thin plate of ZnSe. Radiation leakage from one waveguide to the other through the ZnSe causes the phase locking, and stationary interference fringes demonstrate the relative phase stability. Both waveguide lasers are excited by dc discharges and operate on one of several P or R transitions in the 10.4-μm band. Phase locking occurs whenever both waveguides are on the same transition. An n by m array of such phase-locked lasers has the potential of nearly an (n×m)2 increase in the peak of the lasers’ far-field irradiance distribution.
Fault-tolerance using cache-coherent distributed shared memory systems (2003)

Describes new protocols augmenting traditional cache coherency mechanisms to implement fault tolerance based on recovery blocks and checkpointing. Concurrent processes compound rollback recovery since the rollback can potentially lead to a "domino effect" whereby the process is rolled back to the beginning. Several approaches have been proposed to limit the domino effect. One set of such techniques requires communicating processes to periodically synchronize in order to checkpoint a globally consistent state. These schemes can be implemented more naturally on distributed shared memory systems using synchronization on shared memory. We have developed extensions to well-known cache-coherency methods (e.g. directory-based) for the implementation of checkpointing consistent states.
Predicting mortality in patients with acute heart failure: Role of risk scores (2015)

Acute heart failure is a leading cause of hospitalization and death, and it is an increasing burden on health care systems. The correct risk stratification of patients could improve clinical outcome and resources allocation, avoiding the overtreatment of low-risk subjects or the early, inappropriate discharge of high-risk patients. Many clinical scores have been derived and validated for in-hospital and post-discharge survival; predictive models include demographic, clinical, hemodynamic and laboratory variables. Data sets are derived from public registries, clinical trials, and retrospective data. Most models show a good capacity to discriminate patients who reach major clinical end-points, with C-indices generally higher than 0.70, but their applicability in real-world populations has been seldom evaluated. No study has evaluated if the use of risk score-based stratification might improve patient outcome. Some variables (age, blood pressure, sodium concentration, renal function) recur in most scores and should always be considered when evaluating the risk of an individual patient hospitalized for acute heart failure. Future studies will evaluate the emerging role of plasma biomarkers.
Acoustical Field at Normal Modes in Rooms (1957)

The physical form of the acoustical field at normal complex modes in rooms can be represented as a set of elementary curvilinear ducts, each carrying a single stationary wave, satisfying individually the boundary conditions at the walls. In spite of the differences in their lengths, all the ducts resonate at the same nominal frequency, the differences in their flares adjusting the phase velocity along their axes. This theory is confirmed by the analysis derived from the theory of horns. An experiment on the computed model of the duct yielded with good accuracy the calculated frequency of resonance.
Experimental evaluation of cumulant-based classifiers on noisy images (2002)

The paper describes a cumulant-based classifier whose discrimination criterion exploits statistical signal characteristics of higher order than the second one. The performances of the classifier were tested on texture images. In texture classification, the discrimination criterion is usually based on structural characteristics (edge density, co-occurrence matrix) or on statistical parameters (Gaussian-Markov random fields, fractal dimension) of sample textures. As an alternative to statistical approaches, in this paper a third-order cumulant-based criterion is applied and the classifier's performances on images affected by different types of noise are assessed.
Method for Decreasing Computation Load and Memory Access Frequency during Interpolation for Video Coding (2007)

This paper proposes a method to address the computation load and memory access frequency problems during interpolation for video processing (coding or decoding). The motion compensation process in video processing is computationally intensive and takes considerable computation time of the system, while the interpolation step in the process incurs the heaviest computation load. Exploiting the characteristics of strong correlation between natural images in a frame, this paper proposes a patented method that stores the computed interpolation values and then manages the values using memory address rotation (MAR) technique to decrease the computation load and memory access frequency.
Family history, near work, outdoor activity, and myopia in Singapore Chinese preschool children (2010)

A family history of myopia was the strongest factor associated with preschool myopia. In contrast, neither near work nor outdoor activity was found to be associated with early myopia. These data suggest that genetic factors may play a more substantial role in the development of early-onset myopia than key environmental factors.
Site-selectivity of 3d metal cation dopants and dielectric response in calcium copper titanate (2006)

By doping a few atomic percent of 3d-block cations, we demonstrate that the high dielectric response in CaCu3Ti4O12 can be reduced by a factor of ∼103 at room temperature. Each of the added dopants shows its own preferential substitution on either Cu or Ti sites. The dopants that act as acceptors have a critical impact on the disappearance of the electrostatic potential barrier at grain boundaries, resulting in drastically decreased permittivity values of &lt;90 without voltage dependence. The present doping experiment directly shows that the potential barrier at internal interfaces is a key factor for the peculiar dielectric phenomena.
Intrinsically stretchable and transparent thin-film transistors based on printable silver nanowires, carbon nanotubes and an elastomeric dielectric (2015)

Thin-film field-effect transistor is a fundamental component behind various mordern electronics. The development of stretchable electronics poses fundamental challenges in developing new electronic materials for stretchable thin-film transistors that are mechanically compliant and solution processable. Here we report the fabrication of transparent thin-film transistors that behave like an elastomer film. The entire fabrication is carried out by solution-based techniques, and the resulting devices exhibit a mobility of ∼30 cm(2) V(-1) s(-1), on/off ratio of 10(3)-10(4), switching current >100 μA, transconductance >50 μS and relative low operating voltages. The devices can be stretched by up to 50% strain and subjected to 500 cycles of repeated stretching to 20% strain without significant loss in electrical property. The thin-film transistors are also used to drive organic light-emitting diodes. The approach and results represent an important progress toward the development of stretchable active-matrix displays.
STUDIES ON THE REGULATION OF CERTAIN ESSENTIAL BIOSYNTHETIC SYSTEMS IN NORMAL AND CROWN-GALL TUMOR CELLS (1961)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Genetic Enhancement of Stem Cell Engraftment, Survival, and Efficacy (2008)

Cell-based therapies for the prevention and treatment of cardiac dysfunction offer the potential to significantly modulate cardiac function and improve outcomes in patients with cardiovascular disease. To date several clinical studies have suggested the potential efficacy of several different stem cell types; however, the benefits seen in clinical trials have been inconsistent and modest. In parallel, preclinical studies have identified key events in the process of cell-based myocardial repair, including stem cell homing, engraftment, survival, paracrine factor release, and differentiation that need to be optimized to maximize cardiac repair and function. The inconsistent and modest benefits seen in clinical trials combined with the preclinical identification of mediators responsible for key events in cell-based cardiac repair offers the potential for cell-based therapy to advance to cell-based gene therapy in an attempt to optimize these key events in the hope of maximizing clinical benefit. Below we discuss potential key events in cardiac repair and the mediators of these events that could be of potential interest for genetic enhancement of stem cell-based cardiac repair.
The Catalytic and Lectin Domains of UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Function in Concert to Direct Glycosylation Site Selection (2008)

UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferases (ppGalNAcTs), a family (EC 2.4.1.41) of enzymes that initiate mucin-type O-glycosylation, are structurally composed of a catalytic domain and a lectin domain. Previous studies have suggested that the lectin domain modulates the glycosylation of glycopeptide substrates and may underlie the strict glycopeptide specificity of some isoforms (ppGalNAcT-7 and -10). Using a set of synthetic peptides and glycopeptides based upon the sequence of the mucin, MUC5AC, we have examined the activity and glycosylation site preference of lectin domain deletion and exchange constructs of the peptide/glycopeptide transferase ppGalNAcT-2 (hT2) and the glycopeptide transferase ppGalNAcT-10 (hT10). We demonstrate that the lectin domain of hT2 directs glycosylation site selection for glycopeptide substrates. Pre-steady-state kinetic measurements show that this effect is attributable to two mechanisms, either lectin domain-aided substrate binding or lectin domain-aided product release following glycosylation. We find that glycosylation of peptide substrates by hT10 requires binding of existing GalNAcs on the substrate to either its catalytic or lectin domain, thereby resulting in its apparent strict glycopeptide specificity. These results highlight the existence of two modes of site selection used by these ppGalNAcTs: local sequence recognition by the catalytic domain and the concerted recognition of distal sites of prior glycosylation together with local sequence binding mediated, respectively, by the lectin and catalytic domains. The latter mode may facilitate the glycosylation of serine or threonine residues, which occur in sequence contexts that would not be efficiently glycosylated by the catalytic domain alone. Local sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not.
Only Two Residues Are Responsible for the Dramatic Difference in Receptor Binding between Swine and New Pandemic H1 Hemagglutinin (2010)

In view of its critical role in influenza A virus (IAV) tropism and pathogenesis, we evaluated the receptor binding properties of HA proteins of the closely related swine and new pandemic human IAVs. We generated recombinant soluble trimeric H1 ectodomains of several IAVs and analyzed their sialic acid binding properties using fetuin-binding and glycan array analysis. The results show that closely related swine and new pandemic H1 proteins differ dramatically in their ability to bind these receptors. Although new pandemic H1 protein exhibited hardly any binding, swine H1 bound efficiently to a number of α2-6-linked sialyl glycans. The responsible amino acids were identified by analyzing chimeric H1 proteins and by performing systematic site-directed mutagenesis of swine and new pandemic human H1 proteins. The difference was found to map to residues at positions 200 and 227. Although substitution of either residue significantly affected the binding phenotype, substitution of both was found to act synergistically and reverse the phenotype almost completely. Modeling of the T200A and E227A substitutions into the crystal structure of the new pandemic human H1 protein revealed the loss of potential hydrogen bond formation with Gln(191), which is part of the 190-loop of the receptor binding site, and with the penultimate galactose, respectively. Thus, a residue not belonging to the receptor binding site may affect the interaction of HA with its receptor. Interestingly, whereas alanine at position 200 is found in most new pandemic human viruses, the residue at position 227 in these viruses is invariably a glutamic acid.
Superconductivity in YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-δ</sub> Thick Films by the Atmospheric Plasma Powder Spraying (1988)

Thick films composed of Y-Ba-Cu-O ( e.g. 70 µm thick) were prepared on Ni alloy substrates at various temperatures by the atmospheric plasma powder spraying method. By increasing the substrate temperature during the spraying, the amount of unknown structure in the film sprayed was lowered and the structure of the film sprayed on 600°C substrate was tetragonal in phase. After the postannealing at 600°C, this film revealed superconducting temperatures for onset and zero resistance of 92 K and 86 K, respectively.
Nonlinear decoupled motion-stiffness control and collision detection/reaction for the VSA-II variable stiffness device (2009)

Variable stiffness actuation (VSA) devices are being used to jointly address the issues of safety and performance in physical human-robot interaction. With reference to the VSA-II prototype, we present a feedback linearization approach that allows the simultaneous decoupling and accurate tracking of motion and stiffness reference profiles. The operative condition that avoids control singularities is characterized. Moreover, a momentum-based collision detection scheme is introduced, which does not require joint torque sensing nor information on the time-varying stiffness of the device. Based on the residual signal, a collision reaction strategy is presented that takes advantage of the proposed nonlinear control to rapidly let the arm bounce away after detecting the impact, while limiting contact forces through a sudden reduction of the stiffness. Simulations results are reported to illustrate the performance and robustness of the overall approach. Extensions to the multidof case of robot manipulators equipped with VSA-II devices are also considered.
Comparison of spectral feature algorithms for remote sensing of chlorophyll in eutrophic lakes (2002)

Algorithms to calculate chlorophyll (chl) concentrations of phytoplankton were tested over a range from 0.9 to 47 /spl mu/g chl L/sup -1/ in Mono Lake, California. During four surveys on the lake, samples for determination of chlorophyll were collected and continuous spectra from 400 to 800 nm were obtained with a hand-held spectroradiometer. Remote sensing reflectances were calculated from these spectra. The reflectance peak at 689 nm and the reflectance maximum around 689 mm ratioed to the reflectance maximum around 560 nm predicted chlorophyll concentrations well (r/sup 2/, 0.94 for both).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phosphorylation states of the (Na+ + K+)-transporting ATPase in preparations from lamb kidney and electric-eel (<i>Electophorus electricus</i>) electric organ (1984)

Phosphorylation states of the (Na+ + K+)-transporting ATPase were studied in highly purified preparations isolated from electric-eel electric organ and from lamb kidney. The steady-state level of phosphorylated lamb kidney enzyme, obtained by reaction with [gamma-32P]ATP, was not appreciably reduced in the presence of ADP unless oligomycin was present. The phosphorylated form of the electric-eel electric-organ enzyme was reduced by at least 95% under the same conditions, suggesting that the E1P state in the kidney enzyme is more transitory than that in electric organ. The level of phosphorylation from [32P]Pi was higher in the lamb kidney preparation than in the electric-organ preparation, and the difference in stimulation of phosphorylation by ouabain in the two preparations was striking. Ouabain increased the level of phosphorylation by 35% in the kidney preparation and 734% in the electric-organ preparation. The E2P state seems to be stabilized by ouabain in the latter preparation. These findings, as well as the different reactivities of the thiol groups to blocking reagents in these preparations, suggest that the tertiary structure in the enzyme isolated from these two sources is different.
Rapid isothermal anneal of 75As implanted silicon (1982)

Silicon wafers implanted with 75As have been annealed with a Varian IA-200 isothermal annealer. The anneal occurs in vacuum using radiation from a resistively heated sheet of graphite. The anneal quality depends on the graphite heater temperature and exposure time. If the anneal time is too short implantation damage remains and if the time is too long measurable losses of As occur causing the sheet resistance to increase. The loss of As can be prevented by depositing 0.05 μm of SiO2 on the wafer before annealing.
Bone formation and resorption in patients after implantation of β‐tricalcium phosphate blocks with 60% and 75% porosity in opening‐wedge high tibial osteotomy (2008)

Most of the implanted porous beta-tricalcium phosphate (beta-TCP) can be resorbed. However, beta-TCP block with 75% porosity is inadequate for weight-bearing sites until bone incorporation occurs. Thus, the authors have recently developed beta-TCP block with 60% porosity, which is approximately sevenfold greater in terms of compressive strength than that of beta-TCP with 75% porosity. The authors investigated bone formation and resorption of beta-TCP after implantation in patients of beta-TCP blocks with two different porosities. From May 2003 to November 2004, medial opening high tibial osteotomy was performed in 25 patients with a mean age of 66 years. The opened defect was fixed with a Puddu plate. Then 6-8 cm(3) of beta-TCP block with 75% porosity was used to fill the cancellous bone defect, except on the medial side where 2.83-3.18 cm(3) of wedge-shaped beta-TCP block with 60% porosity was implanted. At least 2 years after surgery, the 25 patients had no correction loss, and bone formation was noted in all cases. Complete or nearly complete resorption of beta-TCP with 60 and 75% porosity was obtained within 3.5 years. Thirteen biopsy samples obtained from the 60% porosity implantation sites showed good lamellar bone formation, and the percentage of beta-TCP remaining relative to the newly formed bone plus beta-TCP ranged from 0.3 to 14.5%, with a mean of 6.7%. The authors suspect that mechanical stress loading to the medial side of the tibia facilitated bone formation and resorption of beta-TCP with 60% porosity.
Magnetic Cell Sorting Is a Fast and Effective Method of Enriching Viable Spermatogonia from Djungarian Hamster, Mouse, and Marmoset Monkey Testes1 (1999)

Germ cell transplantation, which offers promising new approaches for research and clinical applications, has focused interest on spermatogonia. This paper describes a procedure that permits the isolation of large quantities of viable spermatogonia. The immunomagnetic isolation procedure was applied to testicular cell suspensions from photoinhibited and photostimulated Djungarian hamsters, mice, and marmoset monkeys. The cells were incubated with a polyclonal rabbit anti-c-kit IgG, binding of which was characterized by immunohistochemical staining. For magnetic labeling, a secondary anti-rabbit IgG conjugated to ferromagnetic microbeads was used. Separation columns allowed the retention of magnetically labeled cells within the matrix. The magnetic fractions were eluted after removal of the column from the magnetic field. All fractions were analyzed for cellular morphology and by flow cytometry. The final enrichment of c-kit-positive cells in the magnetic fraction using fully active testes was in the range of 25-55% with a viability rate of 80-90%. The magnetic fractions of all three species were characterized by high numbers of diploid cells. Cytological analysis revealed a strong enrichment of spermatogonia. No haploid cells were retained in the magnetic fraction. In comparison to conventional procedures, magnetic cell separation is an efficient and fast approach for isolation of spermatogonia.
Development of a novel direct-drive tubular linear brushless permanent-magnet motor (2004)

This paper presents a novel design for a tubular linear brushless permanent-magnet motor. In this design, the magnets in the moving part are oriented in an NS-NS-SN-SN fashion which leads to higher magnetic force near the like-pole region. An analytical methodology to calculate the motor force and to size the actuator was developed. The linear motor is operated in conjunction with a position sensor, three power amplifiers, and a controller to form a complete solution for controlled precision actuation. Real-time digital controllers enhanced the dynamic performance of the motor, and; gain scheduling reduced the effects of a nonlinear dead band. In its current state, the motor has a rise time of 30 ms, a settling time of 60 ms, and 25% overshoot to a 5-mm step command.. The motor has a maximum speed of 1.5 m/s and acceleration up to 10 g. It has a 10-cm travel range and 26-N maximum pull-out force. The compact size of the motor suggests it could be used in robotic applications requiring moderate force and precision, such as robotic-gripper positioning or actuation. The moving part of the motor can extend significantly beyond its fixed support base. This reaching ability makes it useful in applications requiring a small, direct-drive actuator, which is required to extend into a spatially constrained environment.