gebhart/patrepeval huggingface dataset:
RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model (2013)

The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6-8 weeks) divided into nine groups (n = 10) were used. Anti-inflammatory activity was assessed at 1, 2, 3, 4, and 6 h after subplantar injection of carrageenan (0.1 ml of a 1 % solution in normal saline). Diclofenac alone was studied at 5 and 20 mg/kg, RAD of diclofenac alone at 7.5 ml/kg and their combination at 5 and 7.5 ml/kg, respectively. Diclofenac reduced (p < 0.05 at least) paw edema at all time points. RAD of diclofenac enhanced (p < 0.05) anti-inflammatory effect of diclofenac (5 mg/kg) at 2, 4, and 6 h on concurrent and at 2 and 4 h on sequential administration. Moreover at 2 h, anti-inflammatory effect of combination treatment reached values comparable to those of diclofenac (20 mg/kg). In conclusion, RAD of diclofenac enhanced anti-inflammatory effect of diclofenac.
Application of polymerase chain reaction (PCR) for diagnosis of equine herpes virus-1 (EHV-1). (1996)

Fifty aborted foetus samples were diagnosed for the presence of equine herpes virus-1 (EHV-1) by polymerase chain reaction (PCR) technique. Specific primer pair for amplification of a particular segment of EHV-1 DNA in gc region having 3 Hae III restriction endonuclease sites was used. A 409 base pair segment obtained as PCR amplification product in 9 samples was digested with Hae III to confirm the presence of EHV-1 as the infectious agent in aborted tissues. It was observed that PCR technique was more sensitive, specific and rapid than the conventional virological diagnostic methods.
Electronic structure changes during the surface-assisted formation of a graphene nanoribbon (2014)

High conductivity and a tunability of the band gap make quasi-one-dimensional graphene nanoribbons (GNRs) highly interesting materials for the use in field effect transistors. Especially bottom-up fabricated GNRs possess well-defined edges which is important for the electronic structure and accordingly the band gap. In this study we investigate the formation of a sub-nanometer wide armchair GNR generated on a Au(111) surface. The on-surface synthesis is thermally activated and involves an intermediate non-aromatic polymer in which the molecular precursor forms polyanthrylene chains. Employing angle-resolved two-photon photoemission in combination with density functional theory calculations we find that the polymer exhibits two dispersing states which we attribute to the valence and the conduction band, respectively. While the band gap of the non-aromatic polymer obtained in this way is relatively large, namely 5.25 ± 0.06 eV, the gap of the corresponding aromatic GNR is strongly reduced which we attribute to the different degree of electron delocalization in the two systems.
Transmembrane Signals Mediating Neural Peptide Secretion: Role of Protein Kinase C Activators and Arachidonic Acid Metabolites in Luteinizing Hormone-Releasing Hormone Secretion (1986)

The present experiments were designed to determine the effects of different activators of protein kinase C on the secretion of LHRH from median eminence nerve terminals incubated in vitro. The release of prostaglandin E2 (PGE2), a metabolite of arachidonic acid intimately involved in the secretion of LHRH, was also evaluated. Synthetic diacylglycerol [1,2-didecanoylglycerol (DiC10)] significantly enhanced PGE2 release in a concentration-dependent manner. Blockade of phospholipase A2 (PLA2) activity nullified this effect. LHRH release, on the other hand, was not increased by DiC10. However, in the presence of a lipoxygenase inhibitor, DiC10 produced a concentration-related increase in LHRH release, which paralleled that in PGE2. Phospholipase C (PLC) increased both PGE2 and LHRH secretion. Again, blockade of the lipoxygenase pathway enhanced the release of LHRH by PLC without affecting the stimulated secretion of PGE2. A phorbol ester, phorbol 12,13-dibutyrate (PDBu), markedly increased LHRH secretion while inducing a modest increase in PGE2 release. Both effects of PDBu were unaffected by lipoxygenase inhibition. DiC10, PDBu, and PLC significantly augmented LHRH secretion from tissues in which metabolism of arachidonic acid had been prevented by inhibition of both cyclooxygenase and lipoxygenase pathways, suggesting that activation of protein kinase C, independent of PLA2 activation, can lead to the secretion of this neural peptide. Some lipoxygenase metabolites had either no effect on [5- and 15-hydroxyeicosatetraenoic (5- and 15-HETE)] or induced a marginal stimulation of (12-HETE) LHRH release. At certain concentrations, 12-HETE enhanced the stimulatory effect of the phorbol ester on LHRH release. Our results suggest that activation of protein kinase C can stimulate LHRH secretion from nerve terminals in vitro and, further, that diacylglycerol may represent an important intracellular messenger participating in the events leading to LHRH secretion. In addition, stimulation with DiC10 and PLC uncovered inhibitory [unknown arachidonic acid metabolite(s) via lipoxygenase] and stimulatory (PGE2 via cyclooxygenase) pathways through with arachidonic acid metabolites may participate in the intracellular transduction of signals modulating neural peptide secretion.
Den lilla berättelsen i den stora följetongen. Att undervisa och skriva om den israelisk-palestinska konflikten (2004)

Den lilla berattelsen i den stora foljetongen : att undervisa och skriva om den israel-palestinska konflikten
An Unprecedented Twist to ODCase Catalytic Activity (2005)

Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.
An integrated project planning environment (1993)

The life-cycle of complex engineering products involves many disciplines, each of which is responsible for a stage, or phase, in the design-to-production process. Concurrent engineering principles are capable of bringing together the traditionally disparate groups involved. However, in order to facilitate the essential sharing of product and process information, there is a need to provide a common environment capable of supporting the various requirements of designers, production workers and managers while ensuring that communication and appropriate support is maintained. This paper describes model-based planning research in the construction industry. At the heart of the system are a central generic computer model of a certain type of construction and a knowledge-based system able to apply engineering knowledge in the constraint satisfaction process, leading to a planned sequence of construction activities. The environment comprises the central representation and reasoning mechanism, a symbolic computer-aided design facility, and a commercial project planning and management system. The paper details our experiences in developing and applying the environment in the planning of ‘real-life’ construction projects.
Characterization of two sheep lymphocyte differentiation antigens, SBU-T1 and SBU-T6. (1985)

The monoclonal antibodies 25.91 and 20.27 define two lymphocyte cell surface antigens of sheep. 25.91 is reactive with 60-80% of lymphocytes and 98% of thymocytes, and only stains surface immunoglobulin-negative peripheral lymphocytes. 25.91 immuno-precipitates a 67,000 MW protein from lymphocyte lysates under both reducing and non-reducing conditions, whereas immunoprecipitation of thymocyte lysates reveals a 67,000, 62,000 MW complex. The tissue distribution and molecular weight analysis reported here for the antigen recognized by 25.91 indicate that this antigen is the sheep homologue of the human T1 and mouse Ly 1 antigens. The monoclonal antibody 20.27 is reactive with 80% of thymocytes and the majority of cell surface immunoglobulin-positive peripheral blood lymphocytes (B cells), but is unreactive with peripheral blood T cells. 20-27 also stains Langerhans cells in skin tissue sections and large dendritic-like cells in the paracortex sections and large dendritic-like cells in the paracortex of lymph node tissue sections. Immunoperoxidase staining of thymus tissue sections with 20.27 shows intense staining of cortical thymocytes and an absence of staining within the medulla. Molecular weight analysis of the 20.27 antigen reveals two major bands of 46,000 and 12,000 MW under both reducing and non-reducing conditions. The 20.27 antigen has properties resembling MHC class I-like antigens such as T6 in the human and TL in the mouse.
Print-n-link (2006)

Citations form the basis for a web of scientific publications. Search engines, embedded hyperlinks and digital libraries all simplify the task of finding publications of interest on the web and navigating to cited publications or web sites. However the actual reading of publications often takes place on paper and frequently on the move. We present a system Print-n-Link that uses technologies for interactive paper to enhance the reading process by enabling users to access digital information and/or searches for cited documents from a printed version of a publication using a digital pen for interaction. A special virtual printer driver automatically generates links from paper to digital services during the printing process based on an analysis of PDF documents. Depending on the user setting and interaction gesture, the system may retrieve metadata about the citation and inform the user through an audio channel or directly display the cited document on the user's screen.
NAMBA explorer: a participative location-based city area information sharing system (2005)

We propose a new location-based service (LBS) concept through development of the participative location based city area information sharing system, called NAMBA explorer. The system provides a platform for sharing informal information inputted by users, so this concept differs from most existing LBS providing simple information prepared by a service provider. We found that the concept can be effective in a practical service.
Blood Use in Head and Neck Tumor Surgery (1990)

<i>To the Editor</i>.—I agree with McCulloch and colleagues' endorsement<sup>1</sup>of the use of autologous blood as a reasonable option for the majority of patients with head and neck tumors, and would like to further emphasize the immunosuppressive considerations. Evidence exists for both clinical and laboratory studies that perioperative allogeneic blood transfusions are immunosuppressive. This may be clinically advantageous in transplantation patients, but is undesirable in nontransplantation patients because it may increase the risk of infectious disease complications and the risk of tumor recurrence in patients undergoing curative resection for cancer. While some studies may suggest that perioperative blood transfusions adversely affect disease-free survival following curative resection for malignancy, the results are equivocal. However, there are several studies that show a strong association of allogeneic blood transfusions and resistance to infections. In a series of recent animal studies, it has been shown that allogeneic blood transfusions can increase a
Reduction of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone by PB-3c cells and biological activity of its hydroquinone. (1991)

2,3,5-Trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (CV-6504) has inhibitory activities on both thromboxane A2 synthase and 5-lipoxygenase as well as scavenging activity against active oxygen species. The latter two activities are closely related to the quinone moiety, which is reduced to a hydroquinone in the living body. Comparison of these two activities for both the quinone and hydroquinone showed that the hydroquinone form had superior activities. Concerning the reduction mechanism by PB-3c cells we can see that superoxide dismutase (SOD) has no influence on the rate of reduction, but dicumarol almost completely inhibits the reduction at a concentration greater than 1 x 10(-6) M. Therefore, it can be concluded that CV-6504 is reduced mainly by two electron donating enzymes without the intermediary of a semiquinone radical and that the resulting hydroquinone inhibits lipid peroxidation as well as 5-lipoxygenase activity.
Shape Constancy in Pictorial Relief (1996)

Pictorial relief was measured for a series of pictures of a smooth solid object. The scene was geometrically identical (ie the perspective of the three-dimensional scene remained the same) for all pictures, the rendering different. Some of the pictures were monochrome full-scale photographs taken under different illumination of the scene. Also included were a silhouette (uniform black on uniform white) and a 'cartoon'-style rendering (visual contour and key linear features rendered in thin black line on a uniform white ground). Two subjects were naive and started with the silhouette, saw the cartoon next, and finally the full-scale photographs. Another subject had seen the object and did the experiment in the opposite sequence. The silhouette rendering is impoverished, but has considerable relief with much of the basic shape. The cartoon rendering yields well-developed pictorial relief, even for the naive subjects. Shading adds only small local details, but different illumination produces significant alterations of relief. It is concluded that shape constancy under changes in illumination is dominant throughout, but that the (small) deviations from true constancy reveal the effect of cues such as shading in a natural setting. Such a ¿perturbation analysis' appears more promising than either stimulus-reduction or cue-conflict paradigms.
Total Synthesis of (±)Variotin and Its Analogs (1978)

Abstract 1-Sorboyl-2-pyrrolidone was prepared from sorbic acid and 2-ethoxy-1-pyrroline using 1-methyl-2-chloropyridinium iodide as a coupling reagent. Variotin and its analogs were similarly synthesized from lactim ethers and (2E,4E,6E)-8-hydroxy-2,4,6-dodecatrienoic acids without protecting the hydroxyl group at C-8. (2E,4E,6E)-8-Hydroxy-6-methyl-2,4,6-dodecatrienal, a precursor of trienoic acid, was synthesized by the elimination of methanol from (2E,6E)-8-acetoxy-5-methoxy-6-methyl-2,6-dodecadienal prepared from the reaction of 1-trimethylsiloxy-1,3-butadiene with (2E)-4-acetoxy-2-methyl-2-octenal dimethyl acetal.
Public key superstructure "it's PKI Jim, but not as we know it!" (2008)

While PKI has had its difficulties (like most new technologies) the unique value of public key authentication in paperless transactions is now widely acknowledged. The naïve early vision of a single all-purpose identity system has given way to a more sophisticated landscape of multiple PKIs, used not for managing identity per se, but rather more subtle memberships, credentials and so on. It is well known that PKI's successes have mostly been in closed schemes. Until now, this fact was often regarded as a compromise; many held out hope that a bigger general purpose PKI would still eventuate. But I argue that the dominance of closed PKI over open is better understood as reflecting the reality of identity plurality, which independently is becoming the norm through the Laws of Identity and related frameworks.
Analysis of double- or quadruple-ridged waveguides by a magnetic surface integral equation approach (2002)

The authors present a unified approach to the analysis of ridged waveguides by a magnetic field integral equation (MFIE) formulation. The MFIE approach allows an accurate and complete solution via a simple numerical implementation of pulse basis functions. The emphasis in the present work is on the design of ridged waveguides for applications in microwave components and systems, rather than on details of numerical algorithms. The proposed theory is verified by comparison with exact closed-form solutions and other published results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Expression of a Gene for a Porin-Like Protein of the OmpA Family from<i>Mycobacterium tuberculosis</i>H37Rv (1998)

An open reading frame in the genomic database of Mycobacterium tuberculosis H37Rv was identified as having homology with an outer membrane protein. We found that the gene specified a protein belonging to the OmpA family, which includes some porins of gram-negative organisms. The gene was amplified by PCR and cloned into Escherichia coli. Overexpression of the gene was toxic to the host, but limited amounts could be purified from cells before growth ceased. A truncated gene devoid of the code for a presumed signal sequence was well expressed, but the protein had no pore-forming activity in the liposome swelling assay. However, the intact protein, OmpATb, behaved as a porin of low specific activity, with a pore diameter of 1.4 to 1.8 nm, and was also active in planar lipid bilayers, showing a single-channel conductance of 700 pS. The protein had a molecular mass of about 38 kDa in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A polyclonal rabbit antiserum raised to the truncated protein recognized a protein of similar molecular mass in detergent extracts of broken M. tuberculosis cells. Reverse transcription-PCR confirmed that the gene for OmpATb was expressed in M. tuberculosis cells growing in culture. Comparison of the purified protein with that in the detergent-extracted preparation using liposomes and planar lipid bilayers showed that the two materials had similar pore-forming properties. OmpATb is different from either of the mycobacterial porins described so far. This is the first report of a porin-like molecule from M. tuberculosis; the porin is likely to be important in controlling the access of hydrophilic molecules to the bacterial cell.
Capacity measurements for a 16/spl times/16 element BLAST array over a conducting ground plane (2002)

The paper presents channel transfer function measurements using a 16/spl times/16 "Bell Laboratories layered space-time" (BLAST) antenna array and a wideband measurement system. The capacity of a BLAST system is computed using the H matrix, comprised of the complex transfer functions between each transmitter and receiver element. Measurements were made over a metallic ground plane to allow comparison with an analytical calculation of the H matrix. Using this comparison, it was determined how accurately the H matrix can be measured using a wideband system and hence how accurately the capacity of the BLAST system can be predicted. It was found that the predicted capacities, based on measurements using the 16/spl times/16 system, were within 5% of the theoretical calculations.
Effects of Bienzyme Complex Formation of Cysteine Synthetase from<i>Escherichia coli</i>on Some Properties and Kinetics (2000)

Some properties and kinetics of the free and bound serine acetyltransferases (SATs) and O-acetylserine sulfhydrylase-As (OASS-As) from Escherichia coli were investigated. In some cases, SATdeltaC20, deleting 20 amino acid residues from the C-terminus of the wild-type SAT (Biosci. Biotechnol. Biochem., 63, 168-179 (1999)) was tested for comparison. The optimum pH and stability against some reagents for the free and bound wild-type SATs were similar except for the resistance to cold inactivation. The kinetics for the wild-type SAT and SATdeltaC20 followed a Ping-Pong Bi Bi mechanism with a mixed-type inhibition by L-cysteine. The kinetics and kinetic constants for the wild-type SAT were not changed by the complex formation with OASS-A. The optimum pH for OASS-A was shifted towards an alkaline pH by the complex formation. Thermal stability and stability against some reagents for the free and bound OASS-As were almost the same. On the other hand, the maximum velocity for OASS-A was lowered and dissociation constants for the substrates and products were increased by forming the complex with the wild-type SAT, although the kinetics for the free and bound enzymes followed the same Ping-Pong Bi Bi mechanism. From comparisons of computed courses of L-cysteine formation from L-serine using SAT (wild-type SAT and SATdeltaC20) and OASS-A with the experimental results and changes in the stability of the wild-type SAT by the complex formation, we discuss the role and significance of a complex formation for the cysteine synthetase.
Plasma process-induced damage in SOI devices (2003)

In this work, we show that no plasma damage is induced in Silicon-On-Insulator (SOI) devices with classical antenna test structures. We then study new antenna configurations, and we find out some cases in which low damage does occur in SOI transistors. We explain the results by considering the possible current paths and carrier concentrations in devices, and by using a simple analytical model for electron shading.
Stabilization of single frequency operation of coupled-cavity lasers (1984)

We present a theoretical analysis of cleaved coupled-cavity lasers. Mode selectivity arises from two mechanisms. The first is diffraction loss in the gap between the cleaved sections. The second is based on one section acting as a resonant reflector. Our analysis includes the change of refractive index with carrier density which shifts the cavity resonances and causes mode switching. Above threshold the gains g <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> and g <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> of the two cavities are not pinned, but are related for each mode in the form of a curve in the ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g_{1}, g_{2}</tex> ) plane. The separation of mode curves along a 45° line determines the ratio of mode intensities. Single mode operation above threshold is described by zones in the ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C_{1}, C_{2}</tex> ) plane where C <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> and C <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> are the currents driving the two cavities. Cases of stable, unstable, and bistable operation are discussed.