gebhart/patrepeval huggingface dataset:
Binding Affinity and Specificity of the Estrogen Receptor of the Rat Uterus and Anterior Pituitary (1970)

The soluble supernatant fractions of the uterus and anterior pituitary from ovariectomized adult rats contain 3H-17β-estradiolbinding proteins with identical sedimentation coefficients (8.6±0.2S). Using the Clark and Gorski estrogen receptor assay, the uterine estrogen receptor has a dissociation constant of 1.55×1O−9 (±0.07)M for 3H-17β-estradiol, which is essentially identical with the value of 1.40×10−9 (±0.11)M for the estrogen receptor of the anterior pituitary. The 17β-estradiol binding capacities of the uterus and anterior pituitary estrogen receptors are 0.56 and 0.24 pmole/mg of cell protein, respectively. However, on a per cell basis, the number of receptors in the uterine (∼16,000) or anterior pituitary cell (∼12,000) is of a similar order of magnitude. Estrogenic substances or estrogenic antagonists compete with 3H-17β-estradiol for binding to the receptors of both the anterior pituitary and uterus in the same sequence and to the same degree; that is, diethylstil bestrol≥ethynylestradiol>estrone≥estriol>CI-628>clomiphene. The pH optimum for 3H-17β-estradiol binding activity of the estrogen receptor is between 7 and 8. The decrease in binding activity as the pH is lowered or raised from the optimum is irreversible. The pH inactivation curves of the uterine and anterior pituitary estrogen receptor are the same. The similarities of the uterine and anterior pituitary estrogen receptors– molecular properties and their relationship to estrogen action in these tissues are discussed. (Endocrinology87: 987, 1970)
Determination of the Excitation Temperature in a Nonthermodynamic-Equilibrium High-Pressure Helium Microwave Plasma Torch (1997)

This paper analyzes the influence of the departure from thermodynamic equilibrium on three spectroscopic methods for determining the excitation temperature: the classical Boltzmann plot method, the method of absolute intensity measurements, and the method of the ratio of atomic to ionic lines for one element. Use of these methods is illustrated with experiments conducted in a helium microwave plasma in nonthermodynamic equilibrium produced by an axial injection torch at atmospheric pressure. The excitation temperature was determined at a variable microwave power and different positions along the flame. The results are discussed in terms of the atomic-state distribution function (ASDF) calculated for the plasma.
Regulated expression by readthrough translation from a plasmid-encoded beta-galactosidase (1978)

We have characterized expression of beta-galactosidase from a plasmid cloning vehicle, pBGP120, which carries most of the lacZ gene and contains a single EcoRI site near the end of lacZ. In addition, we have examined expression of heterologous DNA inserted at the position of the EcoRI site. The EcoRI site was shown to be within the sequence coding for beta-galactosidase and its precise location and phase were deduced. Insertion of heterologous EcoRI-generated DNA fragments altered the molecular weight of the plasmid-encoded beta-galactosidase polypeptide. Those insertions that were in the correct phase were expressed at a high level as a fused protein. The different forms of beta-galactosidase polypeptides produced by various hybrid plasmids were all stable proteins. The level of expression of the plasmid-encoded beta-galactosidase was several times higher than maximal expression of chromosome-encoded beta-galactosidase, suggesting that expression is proportional to gene copy number. The expression of the plasmid lacZ gene was controlled by cyclic AMP. When grown in a cya strain (DG74), expression was dependent on exogenous cyclic AMP. Although in normal strains there was insufficient lac repressor to inactivate all copies of the plasmid, repressor regulation was restored when the plasmid was grown in a strain (M96) that overproduces the lac repressor.
Influence of hypothalamic and ambient temperatures on sleep in kangaroo rats (1979)

Unanesthetized, unrestrained kangaroo rats (Dipodomys) were studied to examine the changes in the frequency and duration of sleep states caused by long-term manipulations of hypothalamic temperature (Thy) at a thermoneutral (30 degrees C) and a low (20 degrees C) ambient temperature (Ta). A cold stimulus present in either the hypothalamus or the skin decreased both the total sleep time (TST) and the ratio of paradoxical sleep (PS) to TST. At a low Ta, TST, but not the PS-to-TST ratio, was increased by raising Thy, indicating that a cold peripheral stimulus could differentially inhibit PS. At a thermoneutral Ta, cooling Thy decreased both TST and the PS/TST. Changes in the amount of PS were due largely to changes in the frequency, but not the duration, of individual episodes of PS, suggesting that the transition to PS is partially dependent on the thermoregulatory conditions existing during slow-wave sleep (SWS). These results are consistent with the recent findings that the thermoregulatory system is functional during SWS but is inhibited or inactivated during PS.
MM-121: a human monoclonal antibody ErbB3 antagonist (2008)

3974 The role of the EGFR family in cancer is well documented. To date most of the attention has been focused on EGFR and ErbB2. We have taken a systems approach to understanding ErbB signaling and built a comprehensive computational model of the pathway. Simulations revealed ErbB3 as an ultra-sensitive node in the ErbB pathway and suggested it as a better target for therapeutic intervention. Historically, ErbB3 has not been considered as an attractive target because of its impaired kinase activity and low expression in tumors although recent publications suggest a key role in promoting resistance to EGFR and ErbB2 targeted therapeutics.  Human monoclonal IgG2 antibodies against ErbB3 were then developed and tested in multiple orthogonal assays for the ability to modulate ErbB3 activity and one candidate, MM-121, was chosen to move forward into pre-clinical testing. MM-121 demonstrated potent inhibition of heregulin-induced signaling events in human cancer cell lines.  When MM-121 efficacy was assessed in vivo, MM-121 showed a dose-dependent ability to inhibit tumor growth in multiple xenograft models of human cancer, including ovarian, renal cell, pancreatic and prostate cancer. Pharmacodynamic analysis of samples from these studies showed that chronic MM-121 administration resulted in inhibition of ErbB3 activity which correlated with efficacy.  In vitro antibody binding studies suggested that MM-121 binds to ErbB3 receptors from mouse, rat, cynomolgus monkey and human with a similar affinity. In order to design an efficacious and safe dosing regimen, pre-clinical studies were carried out in mouse, rat and cynomolgus monkey. These studies suggest that MM-121 can safely be administered at serum levels that produce in good inhibition of ErbB signaling and efficacy in xenograft models of cancer.  Cumulatively, these data support that MM-121 could have significant clinical benefit for the treatment of cancer and warrant proceeding forward into phase 1 clinical trials.
Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis (2011)

The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD). Evidence suggests that the effect of apoE isoforms on amyloid-β (Aβ) accumulation in the brain plays a critical role in AD pathogenesis. Like in humans, apoE4 expression in animal models that develop Aβ amyloidosis results in greater Aβ and amyloid deposition than with apoE3 expression. However, whether decreasing levels of apoE3 or apoE4 would promote or attenuate Aβ-related pathology has not been directly addressed. To determine the effect of decreasing human apoE levels on Aβ accumulation in vivo, we generated human APOE isoform haploinsufficient mouse models by crossing APPPS1-21 mice with APOE isoform knock-in mice. By genetically manipulating APOE gene dosage, we demonstrate that decreasing human apoE levels, regardless of isoform status, results in significantly decreased amyloid plaque deposition and microglial activation. These differences in amyloid load between apoE3- and apoE4-expressing mice were not due to apoE4 protein being present at lower levels than apoE3. These data suggest that current therapeutic strategies to increase apoE levels without altering its lipidation state may actually worsen Aβ amyloidosis, while increasing apoE degradation or inhibiting its synthesis may be a more effective treatment approach.
PLC-based optical add/drop switch with automatic level control (1999)

A novel switch configuration for an optical add/drop multiplexer is proposed. By utilizing a certain Mach-Zehnder interferometer both as a component of a double-gate switch and as a level equalizer, we reduced the number of Mach-Zehnder interferometers from five in a conventional switch configuration to three. The add/drop switch simultaneously provides high-isolation switching and polarization-independent automatic level control. The use of planar lightwave circuit (PLC) technology enables this switch to be fabricated with three thermooptic switches (TOSWs) and a monitor tap. High isolation of more than 44 dB and automatic level control accuracy of better than 0.3 dB are achieved. Bit error rate (BER) measurements confirmed switch's usability in the optical add/drop multiplexer.
Gravitational Vortices And Clump Formation In Saturn's F ring During An Encounter With Prometheus (2013)

Saturn rings are most beautiful and dynamic places in the solar system, consisting of ice particles in a constant battle between the gravitational forces of Saturn and its many moons. Fan, spiral, propellers, moonlets and streamer-channels observed by CASSINI in the F-ring have been attributed to encounters by Prometheus on the F ring, with investigations of optical thickness revealing large populations of transient moonlets. Taking into account gravitational interaction between particles and a multi-stranded F-ring structure we show that Prometheus' encounters create rotational flows, like atmospheric vortices and the self-gravity enhances the accelerated growth and size of moonlets. Vortex patches form caustics, which is a primary cause of the transient particle density clumps of 20 km width and 100 km length, and they are elongated to cover an area of 1600 km by 150 km, which may eventually combine into a vortex sheet.
Glossing Over Shoplifting: How Thieves Act Normal (2014)

Although criminals are known to put on a façade of normalcy while offending, no study has categorized the various ways they do so in a theoretically informed manner. We address this gap in the literature by drawing on Goffman's notion of body gloss to explore how shoplifters "act normal" as they enter a store, take possession of and conceal a target, and exit. Our data consist of in-depth descriptions and explanations of active shoplifters who simulated shoplifting at retail stores while wearing an eye-tracking device. We find shoplifters' normalcy-generating actions reflect two of the three types of body gloss outlined by Goffman, and that the type used depends on the stage of shoplifting. Implications for theory and research are discussed.
Practical modification of an efficient public-key framework (2004)

J. Zhou proposed a new public-key framework, in which the maximum lifetime of a certificate is divided into short periods and the certificate could expire at the end of any period under the control of the certificate owner (or his manager in a corporate environment). However, Zhou's public-key framework is not suitable on implementation in real world. Therefore, we review some security parameters and change them into more suitable ones for implementation. Moreover, we remove an unnecessary trust party of Zhou's public-key framework and propose an improved scheme for realistic solution.
Home Automation Routing Requirement in Low Power and Lossy Networks (2008)

This document presents home control and automation application
specific requirements for ROuting in Low power and Lossy networks
(ROLL). In a modern home, a high number of wireless devices are used
for a wide set of purposes. Examples include lighting control,
heating control, sensors, leak detectors, healthcare systems and
advanced remote controls. Because such devices only cover a limited
radio range, multi-hop routing is often required. The aim of this
document is to specify the routing requirements for networks
comprising such constrained devices in a home network environment.
De negocios y transparencia (2013)

Un esfuerzo de moralizacion es deseable en Francia, pero no deberia venderse como una panacea
Purification and structural analysis of pyocyanin and 1-hydroxyphenazine (1986)

Pyocyanin and related members of the phenazine family are produced by Pseudomonas aeruginosa and have been associated with events of pathophysiological importance. Pyocyanin and its base hydrolysis product 1-hydroxyphenazine were purified to homogeneity by reverse-phase high-pressure liquid chromatography. Their mass spectrometric behaviour was examined with a view to evaluating the use of high-resolution chromatography/mass spectrometry in studying phenazine-mediated effects in man. The molecular mass of naturally derived pyocyanin was determined as 210 Da by thermospray liquid chromatography/mass spectrometry and confirmed by desorption electron-impact mass spectrometry. Mass spectrometric data could not be obtained by fast-atom bombardment or desorption chemical ionisation, techniques commonly used to determine molecular mass of polar or thermally labile species. The thermal lability of underivatised pyocyanin precluded analysis by gas chromatography/mass spectrometry. In contrast to pyocyanin, mass spectrometric data were readily obtained for 1-hydroxyphenazine, using direct probe analysis as well as with gas and liquid chromatography inlet systems.
Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa<sup>1</sup>-Arg-(pI)DPhe-Xaa<sup>4</sup>-NH<sub>2</sub> (2017)

The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa<sup>1</sup>-Arg-(pI)DPhe-Xaa<sup>4</sup>-NH<sub>2</sub>] is reported. The scaffold was derived from results obtained from a MC3R mixture-based positional scanning campaign. From these results, a set of 48 tetrapeptides were designed and pharmacologically characterized at the mouse melanocortin-1, -3, -4, and -5 receptors. This resulted in the serendipitous discovery of nine compounds that were MC3R agonists (EC<sub>50</sub> < 1000 nM) and MC4R antagonists (5.7 < pA<sub>2</sub> < 7.8). The three most potent MC3R agonists, 18 [Ac-Arg-Arg-(pI)DPhe-Tic-NH<sub>2</sub>], 1 [Ac-His-Arg-(pI)DPhe-Tic-NH<sub>2</sub>], and 41 [Ac-Arg-Arg-(pI)DPhe-DNal(2')-NH<sub>2</sub>] were more potent (EC<sub>50</sub> < 73 nM) than the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH<sub>2</sub>. This template contains a sequentially reversed "Arg-(pI)DPhe" motif with respect to the classical "Phe-Arg" melanocortin signaling motif, which results in pharmacology that is first-in-class for the central melanocortin receptors.
Joint Optimization of Energy Efficiency and Scheduling Strategies for Side-Link Relay System (2017)

Side-link relay system is targeted to provide critical public safety and broadcast services to extended coverage regions. It is also seen as an enabler for future communication systems supporting vehicular communication like V2V, V2X and as a compliment technique to extend 5G coverage. Enhanced system performance in terms of energy efficiency for overall system (both relay amp;amp; remote UEs) and scheduling strategies while enabling end-to-end QoS is of paramount importance in relay system. The paper targets this twin challenge and proposes novel architecture aspects as well as new approaches for discovery and communication scheduling enabling optimum system performance with DRX alignment and meeting varied QoS targets. Congestion handling during system overload situations is also addressed. Simulation results show proposed QoS scheduling algorithms that consider DRX function achieve substantial gains over the standard QoS-aware algorithm. Results provided derive significant insights for side-link relay system design and implementation.
Ranking Entities on the Web using Social Network Mining and Ranking Learning (2008)

Social networks have garnered much attention recently. Several studies have been undertaken to extract social networks among people, companies, and so on automatically from the web. For use in social sciences, social networks enable analyses of the performance and valuation of companies. This paper describes an attempt to learn ranking of entities from a social network that has been mined from the web. In our approach, we first extract different kinds of relational data from the web. We construct social networks using several relevance measures in addition to text analysis. Subsequently, the relations are integrated to maximize the ranking predictability. We also integrate several relations into a combined-relational network and use the latest ranking learning algorithm to obtain the ranking model. Additionally, we propose the use of centrality scores of companies on the network as features for ranking. We conducted two experiments on a social network among companies to learn the ranking of market capitalization, and on a social network among researchers for ranking of researchers ’ productivity. This study specifically examines a new approach to using web information for advanced analysis by integrating multiple relations among named entities.
Molecular structure of a chiral 3,5-bridged pyridine and the effect of structure on circular dichroic spectra (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structure of a chiral 3,5-bridged pyridine and the effect of structure on circular dichroic spectraJohanna C. Speelman, Auke G. Talma, Richard M. Kellogg, A. Meetsma, J. L. De Boer, Paul T. Beurskens, and W. P. BosmanCite this: J. Org. Chem. 1989, 54, 5, 1055–1062Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/jo00266a012https://doi.org/10.1021/jo00266a012research-articleACS PublicationsRequest reuse permissionsArticle Views503Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Speciation Within <i>Anopheles gambiae</i> -- the Glass Is Half Full (2002)

Restrictions to gene flow among molecular forms of the mosquito Anopheles gambiae sensu stricto reveal an ongoing speciation process affecting the epidemiology of malaria in sub-Saharan Africa.
26% efficient magnesium-doped AlGaAs/GaAs solar concentrator cells (1985)

AlGaAs/GaAs heteroface solar concentrator cells which exhibit 26% efficiency at 753 sun (AM1.5, 100 mW/cm2) have been fabricated using metalorganic chemical vapor deposition. Magnesium was used as the dopant in the p-type emitter and selenium was used as the n-type dopant. The design parameters of the solar cell were determined with the aid of a computer program which realistically models the performance of such cells.
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald (2013)

We present an implementation of explicit solvent all atom classical molecular dynamics (MD) within the AMBER program package that runs entirely on CUDA-enabled GPUs. First released publicly in April 2010 as part of version 11 of the AMBER MD package and further improved and optimized over the last two years, this implementation supports the three most widely used statistical mechanical ensembles (NVE, NVT, and NPT), uses particle mesh Ewald (PME) for the long-range electrostatics, and runs entirely on CUDA-enabled NVIDIA graphics processing units (GPUs), providing results that are statistically indistinguishable from the traditional CPU version of the software and with performance that exceeds that achievable by the CPU version of AMBER software running on all conventional CPU-based clusters and supercomputers. We briefly discuss three different precision models developed specifically for this work (SPDP, SPFP, and DPDP) and highlight the technical details of the approach as it extends beyond previously reported work [Götz et al., J. Chem. Theory Comput. 2012, DOI: 10.1021/ct200909j; Le Grand et al., Comp. Phys. Comm. 2013, DOI: 10.1016/j.cpc.2012.09.022].We highlight the substantial improvements in performance that are seen over traditional CPU-only machines and provide validation of our implementation and precision models. We also provide evidence supporting our decision to deprecate the previously described fully single precision (SPSP) model from the latest release of the AMBER software package.
Cell Wall Metabolism in Ripening Fruit (1980)

Mature ;Bartlett' pear (Pyrus communis) fruits were ripened at 20 C. Fruits at different stages of ripeness were homogenized, and extracts of the low speed pellet (crude cell wall) were prepared. These extracts contained polygalacturonase, pectin esterase, and activity against seven p-nitrophenyl glycoside substrates. Polygalacturonase, alpha-galactosidase, and alpha-mannosidase increased in activity as the fruit ripened. Cellulase and activities against pear wall xylan and arabinan were absent from the extracts.
568. The constitution of geodoxin, a metabolic product of Aspergillus terreus Thom (1959)

C. H. Hassall and T. C. McMorris, J. Chem. Soc., 1959, 2831 DOI: 10.1039/JR9590002831
Medical Complications During Stroke Rehabilitation (1995)

The study shows that inpatient stroke rehabilitation is a medically active service. Management on specialist units is associated with earlier detection and management of stroke-related problems and prevention of potentially life-threatening complications.
Atypical Progression of Acute Renal Failure Associated with Cisplatin Chemotherapy (2013)

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