gebhart/patrepeval huggingface dataset:
Acquiring collocations for lexical choice between near-synonyms (2002)

We extend a lexical knowledge-base of near-synonym differences with knowledge about their collocational behaviour. This type of knowledge is useful in the process of lexical choice between near-synonyms. We acquire collocations for the near-synonyms of interest from a corpus (only collocations with the appropriate sense and part-of-speech). For each word that collocates with a near-synonym we use a differential test to learn whether the word forms a less-preferred collocation or an anti-collocation with other near-synonyms in the same cluster. For this task we use a much larger corpus (the Web). We also look at associations (longer-distance co-occurrences) as a possible source of learning more about nuances that the near-synonyms may carry.
Hemorrhage Results in Hepatic Insulin-Sensitizing Substance-Dependent Insulin Resistance Mediated by Somatostatin in Rats (2006)

The adrenergic system is not involved in producing HDIR in response to hemorrhage. Somatostatin appears to be the hormonal regulator of this response and it is suggested that the somatostatin derives from a neural origin within the liver.
Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis (2015)

We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) peptides that bound to DRβ1-Arg74. We hypothesized that blocking the binding of these peptides to DRβ1-Arg74 could block the continuous T-cell activation in thyroiditis needed to maintain the autoimmune response to the thyroid. The aim of the current study was to identify small molecules that can block T-cell activation by Tg peptides presented within DRβ1-Arg74 pockets. We screened a large and diverse library of compounds and identified one compound, cepharanthine that was able to block peptide binding to DRβ1-Arg74. We then showed that Tg.2098 is the dominant peptide when inducing experimental autoimmune thyroiditis (EAT) in NOD mice expressing human DRβ1-Arg74. Furthermore, cepharanthine blocked T-cell activation by thyroglobulin peptides, in particular Tg.2098 in mice that were induced with EAT. For the first time we identified a small molecule that can block Tg peptide binding and presentation to T-cells in autoimmune thyroiditis. If confirmed cepharanthine could potentially have a role in treating human AITD.
Therapeutic Doll Play in the Treatment of a Severely Impaired Psychiatric Inpatient: Dramatic Clinical Improvements With a Nontraditional Nursing Intervention (2015)

Interest has grown in the use of doll therapy, particularly in geropsychiatric and dementia care settings. In a long-term state psychiatric hospital, a dollhouse-play activity was implemented in an effort to engage an acutely disturbed, middle-aged woman undergoing medication trials and whose symptoms had been refractory to conventional treatments. A schedule of nondirective dollhouse-play activities was implemented over an 8-week period. Measures of behavioral change were tracked. Dramatic clinical improvements were seen, including significant reductions in verbal and physical aggression, use of as-needed medications, and need for close one-to-one monitoring. Improvements were seen prior to achievement of therapeutic drug levels. The patient was successfully discharged from the hospital. Doll play has recently been associated with clinical benefits in the care of patients with dementia and has long been deployed in childhood mental health treatment. The current findings suggest doll play may have applications as a time-limited intervention in the treatment of major psychiatric disorders in adults and warrants consideration when achieving therapeutic alliance has proven particularly challenging.
The safety and therapeutic effectiveness of human red cells stored at — 80°C for as long as 21 years (1989)

Human red cells frozen by various methods have been stored in the frozen state at -80 degrees C for as long as 21 years. This report discusses: red cells frozen with 42 percent weight per volume (wt/vol) glycerol in an ionic medium in a polyvinylchloride (PVC) plastic bag using the Cohn method; red cells frozen with 45 percent wt/vol glycerol in a low ionic medium in a PVC plastic bag using the Huggins method; red cells frozen with 40 percent wt/vol glycerol in an ionic medium in a polyolefin plastic bag using the Meryman-Hornblower method; and red cells frozen with 40 percent wt/vol glycerol in an ionic medium in a standard 600-ml or an elongated 800-ml PVC plastic primary collection bag with an adapter port using the Naval Blood Research Laboratory (NBRL) method. After frozen storage for as long as 21 years by the four methods described above, the thawed red cells were deglycerolized with 50 to 150 ml of 12 percent sodium chloride and 1.5 to 2.0 l of sodium chloride-glucose or sodium chloride-glucose-phosphate solution. After washing and storage at 4 degrees C for 24 hour, the red cells had a mean freeze-thaw-wash recovery value of 90 percent, a mean 24-hour posttransfusion survival value of 85 percent, a mean index of therapeutic effectiveness of 75 percent, normal or slightly impaired oxygen transport function, and minimal hemolysis.(ABSTRACT TRUNCATED AT 250 WORDS)
NMR studies of fluorophenylalanine‐containing carbonic anhydrase (1986)

Rabbits ingesting 4-fluorophenylalanine are known to incorporate small amounts of this fluorinated amino acid into their proteins. Carbonic anhydrase I isolated from the erythrocytes of animals so maintained exhibits a well-resolved fluorine NMR signal for each phenylalanine in the sequence. The chemical shifts of most of these signals respond to the binding of inhibitors, suggesting that most if not all of the tertiary structure of the enzyme adjusts to the presence of inhibitors at the active site.
Effect of Moisture on Piezoresistivity of Carbon Fiber-Reinforced Cement Paste (2008)

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High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration (2002)

The objective of this study was to evaluate whether the interleukin (IL)-1 decoy receptor (R), a negative pathway of regulation of IL-1, is correlated with severity of infection in critically ill patients and reflects the activation of anti-inflammatory pathways by glucocorticoid hormones. Plasma samples were obtained from 101 consecutive, critically ill patients admitted to the intensive care unit with different severities of microbial infection, as defined by standardized criteria. Here, we report that the IL-1 type II decoy R(II) is elevated in critically ill patients, especially in severe, systemic infection and culture-positive infections. In patients with a marked systemic inflammatory response syndrome 4, a pronounced, sepsis-induced further increase of circulating IL-1 decoy RII levels was evident. Thirty-six patients treated with glucocorticoid hormones had significantly higher levels of IL-1 decoy RII, but lower IL-6 and C-reactive protein, than 67 untreated subjects. The usefulness of IL-1RII, in particular as a potential marker for the activation of anti-inflammatory pathways or for responsiveness to anti-inflammatory agents such as glucocorticoid hormones, deserves further analysis.
<i>Methanosarcina mazei</i> LYC, a New Methanogenic Isolate Which Produces a Disaggregating Enzyme (1985)

A methanogenic coccoid organism, Methanosarcina mazei LYC, was isolated from alkaline sediment obtained from an oil exploration drilling site. The isolate resembled M. mazei S-6 by exhibiting different morphophases during its normal growth cycle. It differed from M. mazei S-6 by undergoint a spontaneous shift from large, irregular aggregates of cells to small, individual, irregular, coccoid units. In batch cultures at pH 7.0, M. mazei LYC grew as aggregates during the early growth stage. As the batch culture began exponential growth, the cell aggregates spontaneously dispersed: the culture liquid became turbid, and myriads of tiny (diameter, 1 to 3 mum) coccoid units were observed under phase-contrast microscopy. Disaggregation apparently was accomplished by the production of an enzyme which hydrolyzed the heteropolysaccharide component of the cell wall; the enzyme was active on other Methanosarcina strains as well. Although the enzyme was active when tested at pH 6.0, it apparently was not produced at that pH: when strain LYC was grown at pH 6.0, only cell aggregates were present throughout batch growth. Individual coccoid cells of M. mazei LYC were sensitive to sodium dodecyl sulfate, but the large aggregates of cells were not. Strain LYC rapidly used H(2)-CO(2), in addition to methanol, and mono-, di-, and trimethylamine as methanogenic substrates; acetate was used very slowly. Its optimum growth temperature was 40 degrees C, and its optimum pH was 7.2.
Crises and Turning-Points in the Psychotherapy of a Borderline Adolescent: Poetry as a Marker of Progress (1995)

This article is a case-history of the stormy psychotherapy of a young man with borderline syndrome involving powerful self-hatred and self-destructive urges. His progress in therapy was marked by distinct changes in the poetry he wrote for his therapist.
Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction. (1988)

Detection of human papilloma virus (HPV) types 16 and 18 in formalin-fixed, paraffin-embedded tissue by a new in vitro DNA amplification method, the polymerase chain reaction, was compared with detection with genomic DNA probes using in situ hybridization. The polymerase chain reaction replicates exponentially HPV DNA sequences present in a single 5- to 10-micron paraffin-embedded tissue section. The amplified sequences are detected with a DNA hybridization probe in a dot blot assay. The HPV polymerase chain reaction was able to detect on the average less than one HPV genome/cell as determined by tests of paraffin sections of cell pellets with known HPV genomic content. Cervical sections from 21 patients with HPV types 16, 18, or 31 as determined by in situ DNA hybridization were analyzed by the polymerase chain reaction. No disagreements between the two methods were detected. The sections comprising normal and dysplastic epithelium were further analyzed by the HPV polymerase chain reaction. The presence of virus correlated with the presence of dysplasia in the sections, though 3 of 10 normal sections contained HPV, and 1 of 21 sections with dysplasia lacked HPV 16 or 18. The polymerase chain reaction can specifically detect HPV 16 or 18 with high sensitivity from paraffin-embedded tissues.
Fluorescence diffuse optical tomography using upconverting nanoparticles (2009)

Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.
Quality Dimensions of E-Commerce and their Implications (2007)

Abstract E-commerce business managers are under increasing pressure to justify the value and contribution to the productivity and competitiveness of the organization. It is the quality of their products and services that determines survival. Excellence in quality helps firms gain customer loyalty and achieve competitive edge. Previous studies have suggested the need to develop quality capabilities to improve business performance. However, quality is multi-dimensional, and the development of each dimension requires different sets of resources. It is important for a firm to develop quality capabilities with a focus on a particular set of quality dimensions to support its strategic needs. Quality dimensions are not well established and recent studies indicate that more research is needed. In this paper, authors examine the need for assessment of quality in e-business. The existing quality measures are reviewed to include the emerging success dimensions of service quality and work group impact and provide a comprehensive method for organizing the various measures. Further, a comprehensive set of quality assessment measures are presented that will provide managers with the guidance necessary to develop their own assessment systems. These assessment systems have the potential to furnish the feedback required to enhance the competitiveness of the e-business.
Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia rickettsii infection in dogs (1997)

Dogs were experimentally inoculated with Rickettsia rickettsii to determine if anti-inflammatory or immunosuppressive dosages of prednisolone, when administered in conjunction with an antirickettsial antibiotic (doxycycline), induced therapeutically relevant pathophysiological consequences that ultimately influence disease outcome. Although the duration of rickettsemia was prolonged in dogs receiving immunosuppressive, but not anti-inflammatory, corticosteroids, concurrent administration of doxycycline and corticosteroids conferred no other detected detrimental effects. Treatment with doxycycline or doxycycline in conjunction with prednisolone resulted in decreased R. rickettsii-specific antibody titers; however, examination of appropriately timed acute- and convalescent-phase serum samples would have facilitated an accurate diagnosis of Rocky Mountain spotted fever (RMSF) in all 16 dogs. We conclude that the concurrent use of anti-inflammatory or immunosuppressive doses of prednisolone in conjunction with doxycycline, early in the course of experimental RMSF, confers no clinically relevant detrimental effects and that additional studies might be indicated to detect possible beneficial effects in cases of severe or potentially fulminant RMSF. However, because the illness induced in these dogs was of mild to moderate severity, the results of this study should definitely not be construed as supporting the safety or efficacy of prednisolone for treatment of severe canine or human RMSF.
Reducing Foreclosures: No Easy Answers (2010)

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<i>Progranulin</i> genetic variability contributes to amyotrophic lateral sclerosis (2008)

PGRN acts as a modifier of the course of disease in patients with amyotrophic lateral sclerosis, through earlier onset and shorter survival.
A DC distribution demonstrator incorporating Active Impedance Estimation for marine applications (2010)

A small scale laboratory demonstrator has been constructed to represent a zonal DC distribution system as proposed for future naval vessels. This paper describes how the demonstrator has been used to validate a proposed fault location strategy - Active Impedance Estimation (AIE) - under experimental conditions. The practical processing algorithms required to reduce the effect of noise and the background supply harmonics are presented. The experimental results validate the AIE approach and confirm its robustness and accuracy.
Characterization and Purification of a Bacteriocin Produced by a Potential Probiotic Culture, Lactobacillus acidophilus 30SC (2000)

Lactobacillus acidophilus 30SC was tested for its potential as a probiotic culture. The strain exhibited good acid tolerance in an artificial gastric solution as well as bile resistance in media containing 0.3% bile acids. The strain produced a heat-stable antimicrobial compound that was shown to be proteinaceous in nature and, therefore, referred to as a bacteriocin. The bacteriocin was active over a wide pH range and inhibited a number of gram-positive bacteria including Listeria ivanovii and pathogenic strains. The bacteriocin was purified by 50% ammonium sulfate precipitation followed by hydrophobic interaction column chromatography. The SDS-PAGE of the active fractions resulted in a single band with estimated molecular mass of 3.5 kDa. These results demonstrate the potential of L. acidophilus 30SC as a probiotic culture that can be utilized in the manufacturing of dairy foods and dietary supplements.
A distributed memory and control architecture for 2D discrete wavelet transform (2003)

A distributed memory and control architecture for parallel computation of the 2D discrete wavelet transform is proposed. The architecture is systolic and is obtained by performing a thorough data dependence and localization analysis for the 2D discrete wavelet transform. The design is modular, and can easily be scaled for different levels of wavelet decomposition and filter lengths. The derived architecture for an 8/spl times/8 image has been functionally verified and a chip layout has been obtained in Cadence.
In vitro influence of stem surface finish and mantle conformity on pressure generation in cemented hip arthroplasty (2009)

Femoral stems with rotational instability under cyclic torsional loads generate elevated interface fluid pressures and flows independently of stem surface finish. The rough surface finish is only important in creating this instability in tapered stems.
Using the Amazon Mechanical Turk to Transcribe and Annotate Meeting Speech for Extractive Summarization (2010)

Due to its complexity, meeting speech provides a challenge for both transcription and annotation. While Amazon’s Mechanical Turk (MTurk) has been shown to produce good results for some types of speech, its suitability for transcription and annotation of spontaneous speech has not been established. We find that MTurk can be used to produce highquality transcription and describe two techniques for doing so (voting and corrective). We also show that using a similar approach, high quality annotations useful for summarization systems can also be produced. In both cases, accuracy is comparable to that obtained using trained personnel.
Conflict today and its demands on international society (1995)

Assumes acceptance of the argument that, as the world has become a mere village owing to modern communications systems, trading patterns and the like, it is no longer possible for any individual, community or state to seek to pull down the blinds and ignore what is happening in other parts of the world. This is not merely an ethical issue – although believes that the morality of caring is much in need of an uplift, both in British society and elsewhere – it is a pragmatic and political necessity. Confines discussion to looking at conflicts at the levels where they involve communities or whole states, rather than individuals alone.
HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis (2011)

The mechanisms of CD4(+) T-cell count decline, the hallmark of HIV disease progression, and its relationship to elevated levels of immune activation are not fully understood. Massive depletion of CD4(+) T cells occurs during the course of HIV-1 infection, so that maintenance of adequate CD4(+) T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34(+) hematopoietic progenitor cells directly from the blood of a large set of HIV-infected persons compared with uninfected donors, in particular the elderly. Our analyses underline a marked impairment of primary immune resources with the failure to maintain adequate lymphocyte counts. Systemic immune activation emerges as a major correlate of altered lymphopoiesis, which can be partially reversed with prolonged antiretroviral therapy. Importantly, HIV disease progression despite elite control of HIV replication or virologic success on antiretroviral treatment is associated with persistent damage to the lymphopoietic system or exhaustion of lymphopoiesis. These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments.
Photonics integration on silicon (1999)

ASOC<SUP>TM</SUP> developed by Bookham Technology Ltd is based on Silicon on Insulator ridge waveguide technology. Bookham has demonstrated the low cost, high volume manufacturing capability of ASOC<SUP>TM</SUP> by offering a range of transmitter, receiver and transceiver products to the access market. This range was recently complemented by a number of products in the sensor and DWDM markets. Additional products are currently being developed which illustrate the capability of this technology to provide low volume, high functionality, highly integrated components. In this paper, attention will be given to the range of functionality offered by ASOC and their integration potential.