gebhart/patrepeval huggingface dataset:
Role of the Stress-activated/c-Jun NH2-terminal Protein Kinase Pathway in the Cellular Response to Adriamycin and Other Chemotherapeutic Drugs (1996)

c-Jun NH2-terminal protein kinase (JNK), a member of the mitogen-activated protein kinase family, is activated in response to many stressful stimuli including heat shock, UV irradiation, protein synthesis inhibitors, and inflammatory cytokines. In this study, we investigated whether JNK plays a role in the cellular response to different drugs commonly used in cancer chemotherapy. Treatment of human KB-3 carcinoma cells with Adriamycin resulted in a time- and dose-dependent activation of JNK of up to 40-fold. Treatment with vinblastine or etoposide (VP-16) also activated JNK, with maximum increases of 6.5- and 4.3-fold, respectively. Consistent with these findings, increased c-Jun phosphorylation was observed after drug treatment of cells. In contrast, none of the drugs significantly activated the extracellular response kinase/mitogen-activated protein kinase pathway. Since these drugs are transport substrates for the MDR1 gene product, P-glycoprotein, JNK was assayed in two multidrug-resistant (MDR) KB cell lines, KB-A1 and KB-V1, selected for resistance to Adriamycin and vinblastine, respectively. Relative to KB-3 cells, basal JNK activity was increased 7-fold in KB-A1 cells and 4-fold in KB-V1 cells, with no change in JNK protein expression, indicating that JNK is present in a more highly activated form in the MDR cell lines. Under conditions optimal for JNK activation, Adriamycin, vinblastine, and VP-16 all induced MDR1 mRNA expression in KB-3 cells. Our findings suggest that JNK activation is an important component of the cellular response to several structurally and functionally distinct anticancer drugs and may also play a role in the MDR phenotype.
Spritely NFS: experiments with cache-consistency protocols (1989)

File caching is essential to good performance in a distributed system, especially as processor speeds and memory sizes continue to improve rapidly while disk latencies do not. Stateless-server systems, such as NFS, cannot properly manage client file caches. Stateful systems, such as Sprite, can use explicit cache consistency protocols to improve both cache consistency and overall performance.
[Sleep disturbances in Smith-Magenis syndrome: treatment with melatonin and beta-adrenergic antagonists]. (2010)

Smith-Magenis syndrome is a generic disorder, characterised by physical, neurological and behavioural features and caused by a 17p11.2 deletion. Patients with this syndrome typically display an inversion of the sleep-wake cycle. In this article we describe clinical developments in a two-year-old girl with Smith-Magenis syndrome whose sleep problems were successfully treated with melatonin and beta-adrenergic blockers. We also mention relevant data obtained in our literature search.
Minimum Requirements for Digital Radiography Equipment and Meas- urement Procedures by Different Industries and Standard Organizations (2014)

The digital photography has almost completely substituted the film photography. The film replacement is also fast progressing in medical X-ray radiography. This process is slower in NDT and especially in Europe. Reasons for the hesitating change to digital radiography (RT-D) in NDT are the necessary time for adoption of standards and the conservative request for film RT by auditors and NDT managers for applications in large plants and at construction areas. The fast serial inspection for small castings is already almost completely dominated by RT-D due to the cost effective short exposure and interpretation times. Standards were developed in parallel at CEN, ISO, ASTM and ASME. Unfortunately, the standard practices are different and the requirements on image quality and useable hardware are different too. The first standard series on Computed Radiography were developed and published by CEN and ASTM in 2005. Harmonized classification and qualification standards are available but the published practices are different. ASTM has developed the first standards for application of Digital Detector Arrays (DDA) in 2010. The first digital RT ISO standard practice is ISO 17636-2 (2013), which describes the practice for application of DDAs and Imaging Plates for weld inspection. At the first time this standard provides requirements for the selection of suitable hardware. Minimum image quality requirements are specified in analogy to film radiography and 3 Compensation Principles are defined to enable the application of a wider range of digital detectors. A comparison of the different international digital RT standards is given and first experiences with ISO 17636-2 are discussed. New standards on RT wall thickness and corrosion measurements (EN 16407, film and digital) have been developed recently.
Database research opportunities in computer games (2007)

In this paper, we outline several ways in which the database community can contribute to the development of technology for computer games. We outline the architecture of different types of computer games, and show how database technology plays a role in their design. From this, we identify several new research directions to improve the utilization of this technology in computer games.
Program/Erase Characteristics of Amorphous Gallium Indium Zinc Oxide Nonvolatile Memory (2008)

Currently, both high-density 3-D stacking nonvolatile (NV) memory and embedded NV memory in advanced systems on panel (SOPs) urgently demand the assistance of new and functional transition metal-oxide materials. This is to overcome serious fabrication issues encountered in the use of conventional Si or poly-crystalline Si materials, as well as to increase storage density with lower process cost. This paper reports the fully functional NV memory structure operated by an ionic amorphous oxide semiconductor with a wide energy band gap (> 3.0 eV) in a Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> -ZnO (GIZO) system under low process temperature (< 400degC) while being combined with various metal-oxide materials of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , GIZO, and Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> as the electron charge's tunneling, storage, and blocking layers, respectively. The different methods of memory programs and, especially, the unique erase characteristics caused by a much wider band gap than Si were intensively being investigated, and as a result, excellent electrical results of a large program/erase window over 3.8 V at a pulse time of 10 ms are achieved.
Periodic noise in very low frequency power-line communications (2011)

Very low frequency (VLF) power line communications (PLC) presently has widespread use in AMR/AMI deployments and may also be useful for smart grid applications, largely due to its excellent propagative properties. However, noise within the VLF band is more energetic than at higher frequencies and without effective mitigation algorithms degrades channel capacity, possibly to the point of making the band impractical. Recent work has demonstrated that PLC noise in the low frequency band (LF) and above is effectively modeled as a cyclostationary random process. We present measurements of actual power line noise and argue that the cyclostationary model is unnecessarily restrictive and that VLF PLC channel may be modeled as having a non-trivial wide-sense periodic component. We demonstrate the preponderance of periodic noise in this band by means of constrained covariance estimation from power line noise measurements. This has important ramifications for receiver design and when employed appropriately will increase the post-processed SNR, making VLF PLC a more attractive prospect for smart grid communications.
Black Public Intellectuals: From du Bois to the Present (2005)

Black public intellectuals have unprecedented access to the media, but many no longer have daily contact with African-American communities. A few (mostly men) have become academic and media superstars, which helps sustain the illusion that American society is “color blind.”
The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling (2012)

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structural characteristics and are primarily located in bone and dentin. Accumulating evidence has implicated the SIBLING proteins in matrix mineralisation. Therefore, in this review, we discuss the individual role that each of the SIBLING proteins has in this highly orchestrated process. In particular, we emphasise how the nature and extent of their proteolytic processing and post-translational modification affect their functional role. Finally, we describe the likely roles of the SIBLING proteins in clinical disorders of hypophosphataemia and their potential therapeutic use.
Radial Artery and Ulnar Artery Occlusions Following Coronary Procedures and the Impact of Anticoagulation: <i>ARTEMIS</i> (Radial and Ulnar <i>ARTE</i> ry Occlusion <i>M</i> eta‐Analys <i>IS</i> ) Systematic Review and Meta‐Analysis (2017)

RAO and UAO occur with similar frequency and in the order of 7% to 8% when evaluated early by vascular ultrasonography following coronary procedures. More-intensive anticoagulation is protective. Late recanalization occurs in a substantial minority of patients.
Production of nanocrystalline powders by high-energy ball milling: model and experiment (2008)

A model of high-energy ball milling of powders has been proposed. It is demonstrated that part of the energy is consumed for initiation of microstrains ε during milling and, hence, the process of the powder grinding is decelerated. An analytical expression has been deduced describing the size of nanocrystalline powder particles as a function of the milling time. The model and the experiment have been compared, using a powder of tungsten carbide (WC). The average size of the particles and the value of the microstrains in the ball-milled powder were determined by an x-ray method from broadening of diffraction reflections. The size of the particles was also evaluated using scanning electron microscopy and the sedimentation method.
Comparative Metabolomics Reveals Biogenesis of Ascarosides, a Modular Library of Small-Molecule Signals in <i>C. elegans</i> (2012)

In the model organism Caenorhabditis elegans, a family of endogenous small molecules, the ascarosides function as key regulators of developmental timing and behavior that act upstream of conserved signaling pathways. The ascarosides are based on the dideoxysugar ascarylose, which is linked to fatty-acid-like side chains of varying lengths derived from peroxisomal β-oxidation. Despite the importance of ascarosides for many aspects of C. elegans biology, knowledge of their structures, biosynthesis, and homeostasis remains incomplete. We used an MS/MS-based screen to profile ascarosides in C. elegans wild-type and mutant metabolomes, which revealed a much greater structural diversity of ascaroside derivatives than previously reported. Comparison of the metabolomes from wild-type and a series of peroxisomal β-oxidation mutants showed that the enoyl CoA-hydratase MAOC-1 serves an important role in ascaroside biosynthesis and clarified the functions of two other enzymes, ACOX-1 and DHS-28. We show that, following peroxisomal β-oxidation, the ascarosides are selectively derivatized with moieties of varied biogenetic origin and that such modifications can dramatically affect biological activity, producing signaling molecules active at low femtomolar concentrations. Based on these results, the ascarosides appear as a modular library of small-molecule signals, integrating building blocks from three major metabolic pathways: carbohydrate metabolism, peroxisomal β-oxidation of fatty acids, and amino acid catabolism. Our screen further demonstrates that ascaroside biosynthesis is directly affected by nutritional status and that excretion of the final products is highly selective.
Ion‐beam‐sputter modification of the surface morphology of biological implants (1977)

The surface chemistry and texture of materials used for biologial implants may significantly influence their performance and biocompatibility. Recent interest in the microscopic control of implant surface texture has led to the evaluation of ion beam sputtering as a potentially useful surface roughening technique. Ion sources, similar to electron bombardment ion thrusters designed for propulsive applications, are used to roughen the surfaces of various biocompatible alloys or polymer materials. These materials are typically used for dental implants, orthopedic protheses, vascular prostheses, and artificial heart components. Masking techniques and resulting surface textures are described along with progress concerning evaluation of the biological response to the ion‐beam‐sputtered surfaces.
Vector Field SLAM—Localization by Learning the Spatial Variation of Continuous Signals (2012)

Localization in unknown environments using low-cost sensors on embedded hardware is challenging. Yet, it is a requirement for consumer robots if systematic navigation is desired. In this paper, we present a localization approach that learns the spatial variation of an observed continuous signal over the environment. We model the signal as a piecewise linear function and estimate its parameters using a simultaneous localization and mapping (SLAM) approach. By applying the concepts of the exactly sparse extended information filter (ESEIF) , a constant-time, linear-space algorithm is obtained under certain approximations. We apply our framework to a sensor measuring bearing to active beacons, where measurements are distorted because of occlusion and signal reflections. Experimental results from running GraphSLAM, extended Kalman filter SLAM, and ESEIF-SLAM on manually collected sensor measurements, as well as on data recorded on a vacuum-cleaner robot, validate our model. The ESEIF-SLAM solution is evaluated on an ARM 7 embedded board with 64-kB RAM connected to a Roomba 510 vacuum cleaner. The presented methods are also used in Evolution Robotics ' Mint Cleaner product for autonomous floor cleaning.
Dynamic metabolic engineering: New strategies for developing responsive cell factories (2015)

Metabolic engineering strategies have enabled improvements in yield and titer for a variety of valuable small molecules produced naturally in microorganisms, as well as those produced via heterologous pathways. Typically, the approaches have been focused on up- and downregulation of genes to redistribute steady-state pathway fluxes, but more recently a number of groups have developed strategies for dynamic regulation, which allows rebalancing of fluxes according to changing conditions in the cell or the fermentation medium. This review highlights some of the recently published work related to dynamic metabolic engineering strategies and explores how advances in high-throughput screening and synthetic biology can support development of new dynamic systems. Dynamic gene expression profiles allow trade-offs between growth and production to be better managed and can help avoid build-up of undesired intermediates. The implementation is more complex relative to static control, but advances in screening techniques and DNA synthesis will continue to drive innovation in this field.
Hidden Markov models for speech and signal recognition. (1996)

Hidden Markov methods have become the most widely accepted techniques for speech recognition and modeling. They are based on parametric statistical models which have two components. The first is a Markov chain which produces a sequence of states. This sequence of states characterizes the evolution of a non-stationary process like speech through a set of "short-time" stationary events. The sequence of states is "hidden" from the observer by the second component of the model, a set of output distributions, which governs the manner in which the sequence of states is converted into a sequence of speech observations. The purpose of this paper is first, to describe hidden Markov models (HMMs) as a general signal modeling procedure, second, to describe the application of HMMs to speech recognition and modeling, and, third, to describe other problems to which HMMs have been successfully applied. It is hoped that this discussion will inspire other applications, especially in the area of modeling biological processes represented as continuous waveforms, such as the electroencephalogram (EEG).
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE (2009)

Translational control is widely used to adjust gene expression levels. During the stringent response in bacteria, mRNA is degraded on the ribosome by the ribosome-dependent endonuclease, RelE. The molecular basis for recognition of the ribosome and mRNA by RelE and the mechanism of cleavage are unknown. Here, we present crystal structures of E. coli RelE in isolation (2.5 A) and bound to programmed Thermus thermophilus 70S ribosomes before (3.3 A) and after (3.6 A) cleavage. RelE occupies the A site and causes cleavage of mRNA after the second nucleotide of the codon by reorienting and activating the mRNA for 2'-OH-induced hydrolysis. Stacking of A site codon bases with conserved residues in RelE and 16S rRNA explains the requirement for the ribosome in catalysis and the subtle sequence specificity of the reaction. These structures provide detailed insight into the translational regulation on the bacterial ribosome by mRNA cleavage.
Texas A&M University anarchistic Key authorization (AKA) (1996)

At the Fourth USENIX Security Conference, we presented a paper on SRA Telnet, which was a simple Diffie-Hellman based system to defeat standard password sniffing, without requiring externally validated keys. Since that time, several projects, such as Secure Telnet (stel), have worked to extend this simple Diffie-Hellman model to add data encryption, larger keys, and resistance to man-in-the-middle attack. Other projects, such as SSL and SSH use validated RSA keys for full authentication. This project uses standard PGP keys as the basis of unified authentication, authorization, and encryption, combining both perfect forward secrecy and strong RSA authentication.
29 CCAAT/Enhancer Binding Protein (1992)

OVERVIEW In this chapter, I review the biochemical and regulatory properties of CCAAT/enhancer binding protein (C/EBP). The active form of C/EBP is composed of two polypeptide chains held together by short amphipathic α helices. The dimer interface, termed the “leucine zipper,” mimics the intertwining of α helices in coiled-coil proteins such as keratins and lamins. A polypeptide segment immediately amino-terminal to the leucine zipper is rich in basic amino acids. Dimerization brings two such “basic regions” into close apposition, forming a bivalent DNA contact surface. The basic regions are structurally disordered in the absence of DNA but become α helical once bound. At least five distinct C/EBP-related proteins have been described; all bind DNA in a manner similar to C/EBP and can form mixed dimers in vitro. The amino acid sequences of the C/EBP-related proteins are strikingly similar in the basic and leucine zipper regions, yet differ markedly outside the DNA-binding domain. Various lines of evidence have indicated that the originally defined form of C/EBP, now termed C/EBPcα, may play a key role in terminal cell differentiation. Its temporal pattern of expression is tightly correlated to the conversion of 3T3-L1 fibroblasts into nondividing, fat-laden adipocytes. Antisense inhibition of C/EBPα expression blocks adipocyte conversion. Moreover, premature expression of C/EBPα stimulates the terminal differentiation of adipocytes and causes arrest of mitotic growth in a variety of cultured cell types. INTRODUCTION Studies on C/EBP began in 1984, when Peter Johnson and Barbara Graves were searching independently for proteins in rat liver nuclear extracts...
Relationship of the expression of the S20 and L34 ribosomal proteins to polyamine biosynthesis in Escherichia coli (1995)

Polyamine biosynthesis in Escherichia coli is regulated transcriptionally and post-translationally. Antizyme and ribosomal proteins S20 and L34 participate in post-translational inhibition of the polyamine biosynthetic enzymes ornithine and arginine decarboxylase. The aim of the present study was to investigate the significance of S20 and L34 in polyamine regulation in vivo. In vivo overexpression of S20 and L34 lowered the activities of ornithine and arginine decarboxylases and decreased total polyamine production. The levels of cadaverine, a related diamine whose synthesis is not regulated by S20 and L34, did not decrease but increased. The diminished ornithine and arginine decarboxylase activities are shown to result from reversible post-translational inhibition since the enzymes could be reactivated to normal levels upon titration of the inhibitors. The effects were specific as overexpression of eight other ribosomal proteins had no influence. Overexpression of ornithine decarboxylase results in elevated polyamine production and it increases S20 and L34 levels but not those of other ribosomal proteins. Ornithine depletion decreases S20 and L34 to normal levels in the ornithine decarboxylase overproducing cells. Immunoprecipitation experiments coupled with immunoblots indicated that ornithine and arginine decarboxylases physically interact with S20 and L34. This study shows that ribosomal proteins S20 and L34 can inhibit ornithine and arginine decarboxylases and polyamine biosynthesis in vivo. It is concluded that, unlike other basic ribosomal proteins and polycationic compounds which inhibit the activities of these enzymes only in vitro, S20 and L34 are biologically relevant in the regulation of the polyamine biosynthetic pathway.