gebhart/patrepeval huggingface dataset:
Morphing Soft Magnetic Composites (2012)

Magnet filler-polymer matrix composites (Magpol) are an emerging class of morphing materials. Applications of Magpol can include artificial muscles, drug delivery, adaptive optics and self healing structures. Advantages of Magpol include remote contactless actuation, several actuation modes, high actuation strain and strain rate, self-sensing and quick response. The actuation modes of Magpol, its dynamic properties, work output and transduction characteristics are described. Analogies between Magpol actuation and phase transformations are presented. As an illustration of Magpol actuation, a proof of concept artificial muscle is presented. Current applications and future prospects are described.
Efficacy and safety of low-dose submicron diclofenac for the treatment of osteoarthritis pain: a 12 week, phase 3 study (2014)

Low-dose submicron diclofenac is an effective therapeutic option for the treatment of OA pain.
Kinetic Differences in Cardiac Myosins with Identical Loop 1 Sequences (2001)

The kinetics of nucleotide turnover vary considerably among isoforms of vertebrate type II myosin, possibly due to differences in the rate of ADP release from the nucleotide binding pocket. Current ideas about likely mechanisms by which ADP release is regulated have focused on the hyperflexible surface loops of myosin, i.e. loop 1 (ATPase loop) and loop 2 (actin binding loop). In the present study, we investigated the kinetic properties of rat and pig beta-myosin heavy chains (beta-MHC) in which we have found the sequences of loop 1 (residues 204-216) to be virtually identical, i.e. DQSKKDSQTPKG, with a single conservative substitution (rat E210D pig). Pig myocardium normally expresses 100% beta-MHC, whereas rat myocardium was induced to express 100% beta-MHC by surgical thyroidectomy and subsequent treatment with propylthiouracil. Slack test measurements at 15 degrees C yielded unloaded shortening velocities of 1.1 +/- 0.8 muscle lengths/s in rat skinned ventricular myocytes and 0.35 +/- 0.05 muscle lengths/s in pig skinned myocytes. Similarly, solution measurements at the same temperature showed that actin-activated ATPase activity was 2.9-fold greater for rat beta-myosin than for pig beta-myosin. Stopped-flow methods were then used to assess the rates of acto-myosin dissociation by MgATP both in the presence and absence of MgADP. Although the rates of MgATP-induced dissociation of acto-heavy meromyosin (acto-HMM) were virtually identical for the two myosins, the rate of ADP dissociation was approximately 3.8-fold faster for rat beta-myosin (135 s(-)(1)) than for pig beta-myosin (35 s(-)(1)). ATP cleavage rates were nearly 30% faster for rat beta-myosin. Thus, whereas loop 1 appears from other studies to be involved in nucleotide turnover in the pocket, our results show that loop 1 does not account for large differences in turnover kinetics in these two myosin isoforms. Instead, the differences appear to be due to sequence differences in other parts of the MHC backbone.
Concise Total Synthesis of the Potent Translation and Cell Migration Inhibitor Lactimidomycin (2010)

An efficient total synthesis of the antiproliferative macrolide and cell migration inhibitor lactimidomycin (3) is reported, which relies on the performance of ring closing alkyne metathesis (RCAM). The strained 12-membered 1,3-enyne 21 as the key intermediate was forged with the aid of [(Ph(3)SiO)(3)Mo≡CPh]·OEt(2) (27) as the most effective member of a new generation of powerful alkyne metathesis catalysts. 21 was elaborated to the target by a ruthenium catalyzed trans-hydrosilylation/proto-desilylation sequence and a highly diastereoselective Mukaiyama aldol reaction controlled by oxazaborolidinone 29 as strategic operations.
Reinforcement Learning Applications (2019)

We start with a brief introduction to reinforcement learning (RL), about its successful stories, basics, an example, issues, the ICML 2019 Workshop on RL for Real Life, how to use it, study material and an outlook. Then we discuss a selection of RL applications, including recommender systems, computer systems, energy, finance, healthcare, robotics, and transportation.
Existence and uniqueness of strong solutions to nonlinear nonlocal functional differential equations (2004)

In the present work we consider a nonlinear nonlocal functional differential equations in a real reflexive Banach space. We apply the method of lines to establish the existence and uniqueness of a strong solution. We consider also some applications of the abstract results.
Study on sensing characteristics of three-core photonic crystal fibers (2014)

Total-internal-reflection (TIR) typed fiber sensors based on photonic crystal fibers (PCFs) are made by filling samples into PCF cladding holes, where the interaction of light wave occurs between the evanescent wave of fiber core and the filled samples. This can avoid common transmission losses caused by fiber surface roughness. The interaction region of the evanescent wave in a PCF and the filled samples are almost coincident, so increasing fiber length can enhance the light-matter interaction and enable accurate detection of tiny changes of samples. However, it is difficult to inject sample materials into stomatal cladding of TIR-typed PCF sensors due to small volume of pores. In addition, the energy utilization rates of TIR-typed sensors are relatively low, only about 6%. A main influencing factor on the sensitivity of TIR-typed PCF sensors is the power fraction of pores in the whole cross section. In order to improve the sensitivity, one can elevate the power fraction of PCF pores. Based on the above considerations, a novel three-core double-clad PCF is designed, where samples are injected into the middle hole and two Yd-doped cores are arranged on its two sides for active excitation. Our theoretical calculation and experimental test show that this kind of structure can not only increase the coupling efficiency of the evanescent wave into the air holes effectively, but also gain higher detection sensitivity of trace samples.
Phase behavior of SEBS triblock copolymer gels (2011)

Abstract Dynamic density functional theory calculations were performed for thermoplastic elastomer gels composed of an ABA triblock copolymer immersed in a B‐attractive solvent. The triblock copolymer model was parameterized for poly[styrene‐ b ‐(ethylene‐ co ‐butylene)‐ b ‐styrene] (SEBS), while the solvent model was parameterized for the hydrocarbon oil tetradecane. The effect of the solvent concentration and S‐EB interaction on the morphology was investigated, where complementary experimental data was used to validate results at χ AB N ≈ 100. Agreement was observed at solvent volume fractions of 0.2, 0.4, and 0.6, which correspond to the cylindrical, spherical, and spherical phases, respectively. Qualitative agreement was observed for 0.8 volume fraction solvent, where a core‐shell spherical micelle morphology was found. For a 50/50 vol % mixture of polymer/solvent, the effect of solvent molecular weight on the morphology was considered, where a transition between micro and macrophase separation was predicted at a critical solvent molecular weight. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 1479–1491, 2011
LOCOMOTIVE TRACTION PERFORMANCE MEASUREMENT (1975)

The tonnage rating of a modern locomotive, the maximum train weight it is capable of hauling over a given line without undue risk of stalling, is primarily limited by track adhesion considerations rather than by limitations in the locomotive itself. The maximum tonnage ratings of two locomotives are thus in direct proportion to their maximum tractive efforts when operating on identical track adhesion conditions. Establishing this tractive effort ratio by direct measurement has proven difficult due to unpredictable track adhesion variations. These introduce a great deal of scatter in the tractive effort measurements. A test and analysis method which takes track adhesion variation into account is presented. This method allows the relative hauling capability of two different locomotive types to be evaluated quickly and accurately. Typical test results are presented. Correlation of results with recent operating experience is outlined.
166. The preparation of some stilbene derivatives. Part III (1944)

H. J. Barber and R. Slack, J. Chem. Soc., 1944, 612 DOI: 10.1039/JR9440000612
Parallel field alignment for cross media retrieval (2013)

Cross media retrieval systems have received increasing interest in recent years. Due to the semantic gap between low-level features and high-level semantic concepts of multimedia data, many researchers have explored joint-model techniques in cross media retrieval systems. Previous joint-model approaches usually focus on two traditional ways to design cross media retrieval systems: (a) fusing features from different media data; (b) learning different models for different media data and fusing their outputs. However, the process of fusing features or outputs will lose both low- and high-level abstraction information of media data. Hence, both ways do not really reveal the semantic correlations among the heterogeneous multimedia data. In this paper, we introduce a novel method for the cross media retrieval task, named Parallel Field Alignment Retrieval (PFAR), which integrates a manifold alignment framework from the perspective of vector fields. Instead of fusing original features or outputs, we consider the cross media retrieval as a manifold alignment problem using parallel fields. The proposed manifold alignment algorithm can effectively preserve the metric of data manifolds, model heterogeneous media data and project their relationship into intermediate latent semantic spaces during the process of manifold alignment. After the alignment, the semantic correlations are also determined. In this way, the cross media retrieval task can be resolved by the determined semantic correlations. Comprehensive experimental results have demonstrated the effectiveness of our approach.
Pay Grade Determination Using Cluster Analysis (1995)

This paper applied the cluster analysis technique to group jobs with similarvalue to the organization into pay grades. The cophenetic correlation was usedto select the clustering algorithm that was most similar to the original datamatrix. A modification of the total sum of squares within groups was used todetermine the statistically optimal number of pay grades based on the selectedcluster hierarchy. Applications and limitations of the approaches were discussed to guide practitioners.
Bone Metastases Studied in Experimental Animals (1981)

Professor of Orthopaedic Surgery, University of Manchester, Hope Hospital, Eccles Old Road, Salford M6 8HD, England. Received: April 23, 1980.
Intestinal fistula complicating pancreatic abscess. (1975)

Intestinal fistulization following acute pancreatitis is a complication of abscess formation and may occur after initial surgical drainage. It should be suspected in anyone with protracted pancreatitis in whom an abdominal mass suddenly disappears or in whom gastrointestinal bleeding develops. Although transient improvement may occur, decompression will often be incomplete and will usually be followed by recurrent sepsis or severe life threatening hemorrhage. For this reason, spontaneous fistulization into the intestine does not eliminate the need for adequate surgical drainage. With fistulas into the colon, drainage should be combined with proximal diverting colostomy. Some duodenal fistulas may respond to abscess drainage and intravenously administered hyperalimentation, while others may require drainage plus conversion from a side to an end fistula.
Vibration-induced drop atomization and bursting (2003)

A liquid drop placed on a vibrating diaphragm will burst into a fine spray of smaller secondary droplets if it is driven at the proper frequency and amplitude. The process begins when capillary waves appear on the free surface of the drop and then grow in amplitude and complexity as the acceleration amplitude of the diaphragm is slowly increased from zero. When the acceleration of the diaphragm rises above a well-defined critical value, small secondary droplets begin to be ejected from the free-surface wave crests. Then, quite suddenly, the entire volume of the drop is ejected from the vibrating diaphragm in the form of a spray. This event is the result of an interaction between the fluid dynamical process of droplet ejection and the vibrational dynamics of the diaphragm. During droplet ejection, the effective mass of the drop–diaphragm system decreases and the resonance frequency of the system increases. If the initial forcing frequency is above the resonance frequency of the system, droplet ejection causes the system to move closer to resonance, which in turn causes more vigorous vibration and faster droplet ejection. This ultimately leads to drop bursting. In this paper, the basic phenomenon of vibration-induced drop atomization and drop bursting will be introduced, demonstrated, and characterized. Experimental results and a simple mathematical model of the process will be presented and used to explain the basic physics of the system.
Measuring the power-law exponent of an atmospheric turbulence phase power spectrum with a Shack–Hartmann wave-front sensor (1999)

For non-Kolmogorov turbulence we develop a differential angle-of-arrival fluctuation coefficient, which is the ratio between the transverse and longitudinal differential angle-of-arrival variances, and a slope structure-correlation coefficient, which is the ratio between the transverse and longitudinal differences of the slope correlation function and the slope structure function, to measure the power-law exponent of a phase power spectrum with a Shack–Hartmann wave-front sensor:?The differential arrival-of-angle fluctuation coefficient and the slope structure-correlation coefficient are both related to power-law exponent ? and are independent of strength parameter ?0 of the turbulence. We compare the methods developed and use them to evaluate ? in recently completed horizontal atmospheric experiments for 1000-m laser beam propagation.
Prolonged relief of pain by brief, intense transcutaneous somatic stimulation (1975)

The purpose of this study was to examine the effects of brief, intense transcutaneous electrical stimulations at trigger points or acupuncture points on severe clinical pain. The McGill Pain Questionnaire was used to measure the change in pain quality and intensity produced by stimulation. The data indicate that the procedure provides a powerful method for the control of some forms of severe pathological pain. The average pain decrease during stimulation sessions was 75% for pain due to peripheral nerve injury, 66% for phantom limb pain, 62% for shoulder-arm pain, and 60% for low-back pain. The duration of relief frequently outlasted the period of stimulation by several hours, occasionally for days or weeks. Different patterns of the amount and duration of pain relief were observed. Daily stimulation carried out at home by the patient sometimes provided gradually increasing relief over periods of weeks or months. Control experiments, which included two forms of placebo stimulation, showed that brief, intense electrical stimulation is significantly more effective than placebo contributions. Possible neural mechanisms that underlie these patterns of pain relief by brief, intense stimulation are discussed.
BIOCOMPATIBLE SOLID PHASE MICROEXTRACTION (2006)

Today’s solid phase microextraction (SPME) is a well known technique that combines knowledge from different fields in an attractive, efficient, and economic way. The development of SPME has seen huge growth since its introduction as a new approach to sample preparation in the early 1990s. The applications of SPME are continuously expanding, and one of the most interesting current aspects consists of applying SPME for fast analysis of biological fluids, both in vitro and in vivo.\nIn spite of this great potential, development of new bio-applications is considerably hindered by the lack of suitable SPME products. The goal of this study is to find SPME coatings that can be utilized for in vivo and in vitro extractions, in direct contact with a biological matrix such as blood or tissue. This thesis presents several effective ways of preparing SPME coatings based on biocompatible polymers and silica-based extractive phases, focusing on their biocompatibility as a must. After fabrication, the proposed coatings are tested for biocompatibility and analytical utility.\nFinally, some practical applications of the new coatings are presented, such as fast drug analysis and determination of drug plasma protein binding. Six test drugs with different physico-chemical properties are chosen for the investigation: diazepam, verapamil, lorazepam, warfarin, nordiazepam, and loperamide. It is shown that the application of these new SPME fibers for biological sample analysis greatly reduces the time required for sample preparation and limits the exposure of the analytical personnel to potentially infectious biofluids.
Requirement for Reactive Oxygen Species in Serum-induced and Platelet-derived Growth Factor-induced Growth of Airway Smooth Muscle (1999)

Reactive oxygen species have been recently identified as important mediators of mitogenic signaling in a number of cell types. We therefore explored their role in mediating mitogenesis of airway smooth muscle. The antioxidants catalase, N-acetylcysteine, and probucol significantly reduced proliferation in primary cultures of rat tracheal smooth muscle stimulated with fetal bovine serum or platelet-derived growth factor, without affecting cell viability or inducing apoptosis. N-Acetylcysteine also significantly reduced serum-stimulated elevation of c-Fos but did not prevent the normal mitogen-induced increase in c-fos mRNA. Fractionation of ribosomes by sucrose density centrifugation and subsequent dot-blot Northern analysis revealed that antioxidants reduced incorporation of c-fos mRNA into the heaviest polyribosomes, suggesting redox regulation of c-fos mRNA translation. Serum treatment of monolayers produced a small but reproducibly significant rise in superoxide dismutase-inhibitable reduction of ferricytochrome c by myocyte monolayers. Serum-induced ferricytochrome c reduction, cellular proliferation, and c-Fos elevation were decreased by the flavoprotein-dependent enzyme inhibitor dipheyleneiodonium. Growth responses to fetal bovine serum and superoxide dismutase-inhibitable reduction of ferricytochrome c were not different between cultured tracheal myocytes from wild-type versus gp91 phagocyte oxidase null mice. These results suggest that mitogen stimulation of airway smooth muscle induces signal transduction of cell proliferation that is in part dependent on generation of partially reduced oxygen species, generated by an NADH or NADPH oxidoreductase that is different from the oxidase in phagocytic cells.
Triazines as anti-inflammatory agents. (1994)

5,6-Diphenyl 1,2,4-triazine-3-thiol (III) was synthesized from alpha-diketone benzyl (II); II in turn was synthesized from benzoin (I). III on reaction with 1-chloro-2,3-epoxy propane yielded 3-[(oxiranyl methyl)thio]-5,6-diphenyl 1,2,4-triazine (IV). IV was converted to 3-[5,6-diphenyl-1,2,4-triazine-3-yl thio]-3-substituted propanols (V) on reaction with aryl amines. These compounds were screened for their anti-inflammatory activity in albino rats with carrageenin induced paw oedema. Two compounds, Ve and Vl, exhibited significant anti-inflammatory activity compared to the standard, phenylbutazone, with high ALD50 values.
Polyion Complex Micelles with Protein-Modified Corona for Receptor-Mediated Delivery of Oligonucleotides into Cells (1999)

Graft-copolymers, containing poly(ethylene glycol) (PEG) and polyethyleneimine (PEI) chains have been proposed as carriers for delivery of phosphorothioate oligonucleotides (SODNs). Complexes of such copolymers with SODN self-assemble into particles having a core of neutralized PEI and SODN and a corona of PEG. Transferrin molecules are attached to the PEG corona using avidin/biotin construct. For this purpose, biotin moieties are covalently linked to the free ends of the PEG chains in the PEG-g-PEI copolymer. SODNs are reacted with mixtures of biotinylated and biotin-free PEG-g-PEI copolymers of various compositions to adjust the number of the biotin moieties in the complex. Resulting complexes have small size (ca. 40 nm) and do not aggregate in aqueous solutions for at least several days. To attach transferrin, they are supplemented first with avidin and then with biotin-transferrin conjugate. This increases the effective diameter of the particles to ca. 75-103 nm, depending on the composition of the complex. Cellular accumulation and fluorescence microscopy studies characterize the effects of these modifications on interaction of fluorescently labeled SODNs with KBv cell monolayers. The data suggest significant enhancement of SODN association with cells resulting from modification of the complex with transferrin. SODN complimentary to the site 546-565 of human mdr 1-mRNA was used to inhibit expression of the drug efflux transporter, P-glycoprotein (P-gp), in multiple drug resistant (MDR) cancer cells (KBv, MCF-7 ADR). Accumulation of a P-gp specific probe, rhodamine 123, in the cell monolayers is used to characterize the effects on P-gp efflux system following the treatment of the cells with antisense SODN or its complexes. This study suggests that antisense SODN incorporated in the complexes retain the ability to inhibit P-gp efflux system, while complexes of the randomized control SODN are inactive. Therefore, the antisense SODN is released from the complex and interacts with its intracellular target upon interaction of the complexes with the cells. Furthermore, modification of the complexes with transferrin leads to a significant increase of the effects of the antisense SODN on the P-gp efflux system in the cells. Overall, this study suggests that polyion complex micelles with protein-modified corona are promising tools for the delivery of antisense SODN.
Remote ischaemic conditioning: cardiac protection from afar (2015)

For patients with ischaemic heart disease, remote ischaemic conditioning may offer an innovative, non-invasive and virtually cost-free therapy for protecting the myocardium against the detrimental effects of acute ischaemia-reperfusion injury, preserving cardiac function and improving clinical outcomes. The intriguing phenomenon of remote ischaemic conditioning was first discovered over 20 years ago, when it was shown that the heart could be rendered resistant to acute ischaemia-reperfusion injury by applying one or more cycles of brief ischaemia and reperfusion to an organ or tissue away from the heart - initially termed 'cardioprotection at a distance'. Subsequent pre-clinical and then clinical studies made the important discovery that remote ischaemic conditioning could be elicited non-invasively, by inducing brief ischaemia and reperfusion to the upper or lower limb using a cuff. The actual mechanism underlying remote ischaemic conditioning cardioprotection remains unclear, although a neuro-hormonal pathway has been implicated. Since its initial discovery in 1993, the first proof-of-concept clinical studies of remote ischaemic conditioning followed in 2006, and now multicentre clinical outcome studies are underway. In this review article, we explore the potential mechanisms underlying this academic curiosity, and assess the success of its application in the clinical setting.