gebhart/patrepeval huggingface dataset:
Monoclonal anti‐D specificity and Rh D structure: criteria for selection of monoclonal anti‐D reagents for routine typing of patients and donors (1995)

The Rh blood group system is the next most important to the ABO system in terms of its clinical significance in blood transfusion. It is vital to the safe, efficient practice of transfusion medicine that Rh D phenotyping tests are selected, executed and interpreted correctly. However, the Rh D blood group antigen has been shown to be subject to many phenotypic variations, and different reagents and typing techniques vary in their ability to detect these variants. The range of D-positive phenotypes are reviewed in terms of their reactivity with monoclonal antibody reagents and their clinical significance. In view of the available evidence, it is suggested that patient typing can be safely achieved by the duplicate use of one high-avidity or two very similar IgM monoclonal anti-D reagents that detect most variants except category DVI in simple tube or microplate saline tests. Antiglobulin testing for weak D should not be carried out on patient samples. Donor typing can be safely achieved by the use of the same monoclonal, used in parallel with a polyclonal anti-D reagent that detects DVI on sensitive automated equipment.
The Pharmacological Actions of Certain Aromatic Diamidines Possessing Trypanocidal Activity (1943)

(1943). The Pharmacological Actions of Certain Aromatic Diamidines Possessing Trypanocidal Activity. Annals of Tropical Medicine & Parasitology: Vol. 37, No. 1, pp. 1-18.
Dynamic Tensile Properties of Human Skin (2012)

IRCOBI Conference 2012, 12 - 14 September 2012, Dublin (Ireland)
A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome (2014)

This study establishes the feasibility of IGF-1 treatment in PMS and contributes pilot data from the first controlled treatment trial in the syndrome. Results also provide proof of concept to advance knowledge about developing targeted treatments for additional causes of ASD associated with impaired synaptic development and function.
COMPARING THE ACHIEVEMENT OF STUDENTS TAUGHT BY PART‐TIME VERSUS FULL‐TIME FACULTY (1986)

This study compares the instructional effectiveness of full‐time with part‐time faculty by assessing the subsequent achievement of their students. The 1,075 students under study enrolled in English 1101 at Miami‐Dade Community College where half of the 38 sections they comprised were taught by part‐time faculty. Using grades in the next English course and scores on a competency‐based exit exam as measures of subsequent achievement, the study found no differences between students of part‐time and full‐time faculty
Canyon lithography (1983)

We describe a simple resist structure for implementing brushfire lithography (BFL) in electron-beam writing. The outlines of the pattern features are written as narrow deep openings formed in a single layer of positive electron resist. An oblique evaporation of a metal film onto the surface yields outlined electrically isolated metal copies of the features. These can be toned by selective electrically controlled etching. Transfer of the metal pattern to the underlying resist completes the structure.
Feature Generating Networks for Zero-Shot Learning (2017)

Suffering from the extreme training data imbalance between seen and unseen classes, most of existing state-of-the-art approaches fail to achieve satisfactory results for the challenging generalized zero-shot learning task. To circumvent the need for labeled examples of unseen classes, we propose a novel generative adversarial network (GAN) that synthesizes CNN features conditioned on class-level semantic information, offering a shortcut directly from a semantic descriptor of a class to a class-conditional feature distribution. Our proposed approach, pairing a Wasserstein GAN with a classification loss, is able to generate sufficiently discriminative CNN features to train softmax classifiers or any multimodal embedding method. Our experimental results demonstrate a significant boost in accuracy over the state of the art on five challenging datasets -- CUB, FLO, SUN, AWA and ImageNet -- in both the zero-shot learning and generalized zero-shot learning settings.
Structure Activity Relationship Study and Recent Advances in the Design and Synthesis about Linear Antimicrobial Peptides (2002)

Numerous defense peptides (cationic antimicrobial peptides) were isolated from eukaryotic systems and their functions were studied. In spite of size, primary sequences, and structures, most of them shared common features. They preferentially bind to lipid membranes of microbes and increase permeability of lipid membranes as a primary mode of action. The characteristics of cationic antimicrobial peptide different from conventional antibiotics make themselves a candidate for novel antimicrobial agents. In this review, we will provide a general overview of linear antimicrobial peptides with emphasis on aspects such as structure, biological mode, and structural parameters for activity and selectivity in vitro. And this review will focus on recent design and synthesis of novel peptide analogs with enhanced stability and selectivity. Keywords: antimicrobial peptide, cationic antimicrobial peptide, linear antimicrobial, cationic antimicrobial
Application study of 1,2-α-<scp>l</scp>-fucosynthase: introduction of Fucα1-2Gal disaccharide structures on <i>N</i>-glycan, ganglioside, and xyloglucan oligosaccharide (2016)

We have recently generated a highly efficient 1,2-α-l-fucosynthase (BbAfcA N423H mutant) by protein engineering of 1,2-α-l-fucosidase from Bifidobacterium bifidum JCM 1254. This synthase could specifically introduce H-antigens (Fucα1-2Gal) into the non-reducing ends of oligosaccharides and in O-linked glycans in mucin glycoprotein. In the present study, we show an extended application of the engineered 1,2-α-l-fucosynthase by demonstrating its ability to insert Fuc residues into N- and O-glycans in fetuin glycoproteins, GM1 ganglioside, and a plant-derived xyloglucan nonasaccharide. This application study broadens the feasibility of this novel H-antigen synthesis technique in functional glycomics.
Removal of Fermentation Inhibitors Formed during Pretreatment of Biomass by Polymeric Adsorbents (2002)

The production of aldehydes that are microbial inhibitors may occur when hexoses and pentoses in an aqueous solution are exposed to temperatures above 150 °C under acidic conditions common to acid-catalyzed lignocellulose biomass pretreatment. Concentrations greater than 0.1% of the degradation product, furfural, strongly inhibit fermentation, as was confirmed for hydrolysate that contained 0.5% (w/o) furfural. Methods of furfural removal that have been reported include sulfite or alkali addition to achieve chemical reduction, ion exchange, hydrophobic adsorption, and irreversible adsorption on activated carbon. This paper reports the removal of furfural from biomass hydrolysate by a polymeric adsorbent, XAD-4, and desorption of the furfural to regenerate the adsorbent using ethanol. Liquid chromatographic analysis showed that furfural concentrations were less than 0.01 g/L compared to the initial concentrations that were in the range of 1−5 g/L. Fermentation of the resulting biomass hydrolysate with recombinant Escherichia coli ethanologenic strain K011 confirmed that the concentration of furfural in the hydrolysate caused negligible inhibition. Fermentation of XAD-4-treated hydrolysate with E. coli K011 was nearly as rapid as the control medium that was formulated with reagent-grade sugars of the same concentration. Ethanol yields for both fermentations were 90% of theoretical. Modeling of the adsorptive properties of this styrene-based adsorbent indicates that it is suitable for on−off chromatography and could be useful in a continuous processing system for removing small amounts of aldehydes that might otherwise inhibit fermentation.
Elastic Kirchhoff migration for vertical seismic profiles (1987)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1987Elastic Kirchhoff migration for vertical seismic profilesAuthors: Timothy H. KehoRu‐Shan WuTimothy H. KehoARCO Oil and Gas Co. and Ru‐Shan WuUniversity of California at Santa Cruzhttps://doi.org/10.1190/1.1891961 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1891961FiguresReferencesRelatedDetailsCited byElastic Gaussian-Beam Migration for PP and PS Imaging Using Single-Component Seismic DataIEEE Geoscience and Remote Sensing Letters, Vol. 20The Usage of Grid-Characteristic Method in Seismic Migration Problems9 January 2019Isotropic elastic reverse time migration using the phase- and amplitude-corrected vector P- and S-wavefieldsJidong Yang, Hejun Zhu, Wenlong Wang, Yang Zhao, and Houzhu Zhang1 October 2018 | GEOPHYSICS, Vol. 83, No. 6Migration of Elastic Wavefield Using Adjoint Operator and Born Approximation17 February 2018Migration of Elastic Fields Based on Kirchhoff and Rayleigh Integrals17 February 2018Reverse time migration with elastodynamic Gaussian beams23 March 2016 | Journal of Earth Science, Vol. 28, No. 4References24 May 2016Multicomponent joint migration velocity analysis in the angle domain for PP-waves and PS-wavesQizhen Du, Fang Li, Jing Ba, Yitong Zhu, and Bo Hou15 February 2012 | GEOPHYSICS, Vol. 77, No. 1Elastic Kirchhoff migration of vectorial wave-fields8 January 2009 | Applied Geophysics, Vol. 5, No. 4Parsimonious migration of 3-C 3D VSP dataYogesh Agnihotri and George A. McMechan13 September 2007 | GEOPHYSICS, Vol. 72, No. 6MIGRATION OF MIXED-MODE VSP WAVEFIELDS1Geophysical Prospecting, Vol. 36, No. 8 SEG Technical Program Expanded Abstracts 1987 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1987 Pages: 923 publication data© 1987 Copyright © 1987 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 07 Mar 2005 CITATION INFORMATION Timothy H. Keho and Ru‐Shan Wu, (1987), "Elastic Kirchhoff migration for vertical seismic profiles," SEG Technical Program Expanded Abstracts : 774-776. https://doi.org/10.1190/1.1891961 Plain-Language Summary PDF DownloadLoading ...
Securing XML data (2004)

XML is becoming one of the most important and widely used data formats. XML data in transit over the Internet as well as the data residing on servers must be assessed for XML associated security vulnerabilities and be properly secured from malicious XML specific attacks. There are several options in implementing XML security devices such as firewalls. Users need to understand how XML relates and interacts with Internet applications.
Surgical Glove Powders Bind Latex Antigens (1992)

Latex surgical gloves have recently been identified as a potential source of allergens. Much of the current information suggests that the soluble proteins in latex may cause significant reactions in sensitive individuals. The starch powders used as a lubricant on some latex gloves have also been identified as potential allergens in some patients. In this study, we determined these powders to act as potential carriers of latex allergens. We have produced a polyclonal antiserum to be used as a reagent to study latex proteins. By Western blot analysis, we identified a significant interaction between latex proteins and starch powders. The binding of latex proteins to starch particles results in a glove particle that may have an increased potential to act as an allergen. The latex protein-starch particles represent a potential mechanism for exposure and sensitization of health care workers to latex allergens. Elimination of these particles from the operating room should reduce the route of sensitization and the potential for adverse reactions to latex.
Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach. (1989)

Patients with serious inflammatory Graves' ophthalmopathy should be treated with anti-inflammatory drugs or radiotherapy to prevent complications like fibrosis, while those with non-inflammatory ophthalmopathy may be treated by surgery immediately. It is often difficult, however, to distinguish inflammatory from non-inflammatory Graves' disease. We therefore present a simple clinical classification here to differentiate between these two conditions. This classification is based on the classical signs of inflammation--pain, redness, swelling, and impaired function. After two consecutive clinical examinations an 'activity score' can be determined, ranging from 0 to 10 points. In a retrospective study testing the efficacy of this classification we found that patients with an activity score of 3 or more at the beginning of therapy responded well to anti-inflammatory drugs, while those with a lower activity score mostly did not. Comparing the pretreatment activity score with the degree of enlargement of the extraocular muscles on the CT scan, we found a significant correlation between these two parameters: the higher the activity score, the more the enlargement of the muscles. We conclude that this classification facilitates the proper selection of patients for treatment.
Activity of chimeric RNAs of U6 snRNA and (-)sTRSV in the cleavage of a substrate RNA (1992)

U6 small nuclear RNA is one of the spliceosomal RNAs essential for pre-mRNA splicing. Discovery of mRNA-type introns in the highly conserved region of the U6 snRNA genes led to the hypothesis that U6 snRNA functions as a catalytic element during pre-mRNA splicing. The highly conserved region of U6 snRNA has a structural similarity with the catalytic domain of the negative strand of the satellite RNA of tobacco ring spot virus [(-)sTRSV], suggesting that the highly conserved region of U6 snRNA forms the catalytic center. We examined whether synthetic RNAs consisting of the sequence of the highly conserved region of U6 snRNA or various chimeric RNAs between the U6 region and the catalytic RNA of (-)sTRSV could cleave a substrate RNA that can partially base-pair with them and have a GU sequence. Chimeric RNAs with 70 to 83% sequence identity with the conserved region of S. pombe U6 snRNA cleaved the substrate RNA at the 5' side of the GU sequence, which is shared by the 5' end of an intron in a pre-mRNA. We found that the highly conserved region of U6 snRNA and the catalytic domain of (-)sTRSV are strikingly similar in structure to the catalytic core region of the group I self-splicing intron in cyanobacteria. These results suggest that U6 snRNA, (-)sTRSV and the group I self-splicing intron originated from a common ancestral RNA, and support the hypothesis that U6 snRNA catalyzes pre-mRNA splicing reaction.
Cannabinoid Receptor Antagonist-Induced Striated Muscle Toxicity and Ethylmalonic-Adipic Aciduria in Beagle Dogs (2012)

Ibipinabant (IBI), a potent cannabinoid-1 receptor (CB1R) antagonist, previously in development for the treatment of obesity, causes skeletal and cardiac myopathy in beagle dogs. This toxicity was characterized by increases in muscle-derived enzyme activity in serum and microscopic striated muscle degeneration and accumulation of lipid droplets in myofibers. Additional changes in serum chemistry included decreases in glucose and increases in non-esterified fatty acids and cholesterol, and metabolic acidosis, consistent with disturbances in lipid and carbohydrate metabolism. No evidence of CB1R expression was detected in dog striated muscle as assessed by polymerase chain reaction, immunohistochemistry, Western blot analysis, and competitive radioligand binding. Investigative studies utilized metabonomic technology and demonstrated changes in several intermediates and metabolites of fatty acid metabolism including plasma acylcarnitines and urinary ethylmalonate, methylsuccinate, adipate, suberate, hexanoylglycine, sarcosine, dimethylglycine, isovalerylglycine, and 2-hydroxyglutarate. These results indicated that the toxic effect of IBI on striated muscle in beagle dogs is consistent with an inhibition of the mitochondrial flavin-containing enzymes including dimethyl glycine, sarcosine, isovaleryl-CoA, 2-hydroxyglutarate, and multiple acyl-CoA (short, medium, long, and very long chain) dehydrogenases. All of these enzymes converge at the level of electron transfer flavoprotein (ETF) and ETF oxidoreductase. Urinary ethylmalonate was shown to be a biomarker of IBI-induced striated muscle toxicity in dogs and could provide the ability to monitor potential IBI-induced toxic myopathy in humans. We propose that IBI-induced toxic myopathy in beagle dogs is not caused by direct antagonism of CB1R and could represent a model of ethylmalonic-adipic aciduria in humans.
Sequence comparison of the 5' end of mRNA 3 from transmissible gastroenteritis virus and porcine respiratory coronavirus (1991)

Analysis of porcine transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) mRNA species indicated a deletion in mRNA 3 of PRCV. Polymerase chain reaction (PCR) was used to clone the 5' end of mRNA 3 from PRCV for comparison with the equivalent region in TGEV. Small deletions were observed within and around the PRCV sequence equivalent to the putative open reading frame (ORF) ORF-3a identified in TGEV. The potential RNA polymerase-leader complex binding site (leader RNA binding site), ACTAAAC, found upstream of ORF-3a in TGEV, was absent from the PRCV genome but a potential site was found in the PRCV genome upstream of a gene equivalent to TGEV ORF-3b. PCR analysis, using primers corresponding to sequences within the ORF-3b gene and the leader RNA sequence, confirmed that the leader RNA binding site was upstream of a gene equivalent to TGEV ORF-3b on PRCV mRNA 3 but upstream of ORF-3a on TGEV mRNA 3. The presence of the new leader RNA binding site would be responsible for generating the smaller mRNA 3 species found in PRCV-infected cells.
Detection of three separate DNA polymorphisms in the human lipoprotein lipase gene by gene amplification and restriction endonuclease digestion. (1992)

A rapid detection method was developed for DNA polymorphisms in the human lipoprotein lipase (LPL) gene. The examined polymorphisms include an A-C transversion in the 5'-region of intron 3, a T-G transversion that occurs within a Hind III site of intron 8, and the previously described C-T transition that causes a Pvu II polymorphism in intron 6. Gene fragments encompassing each polymorphic site were amplified by the polymerase chain reaction (PCR) and digested with an appropriate restriction enzyme whose recognition site was either naturally affected by the polymorphism or artificially created with a mismatched PCR-primer. According to the digestion profiles, genotypes were unambiguously distinguished. With this method, respective allelic frequencies were determined for 50 or 70 normal subjects. The procedure will facilitate LPL genotyping in the large population.
Improved strain precision with high spatial resolution using nanobeam precession electron diffraction (2013)

NanoBeam Electron Diffraction is a simple and efficient technique to measure strain in nanostructures. Here, we show that improved results can be obtained by precessing the electron beam while maintaining a few nanometer probe size, i.e., by doing Nanobeam Precession Electron Diffraction (N-PED). The precession of the beam makes the diffraction spots more uniform and numerous, making N-PED more robust and precise. In N-PED, smaller probe size and better precision are achieved by having diffraction disks instead of diffraction dots. Precision in the strain measurement better than 2 × 10−4 is obtained with a probe size approaching 1 nm in diameter.
Effects of salicylic acid on growth and ornamental characteristics of Persian petunia (Petunia hybrida) under salt stress. (2012)

Abstract Application of salicylic acid (SA) as a phytohormone has been increased due to resistance to stresses such as salt stress. To evaluate the effects of SA on growth and ornamental characteristics of Persian petunia under salt stress, a factorial experiment, based on completely randomized design, was conducted with 3 levels of SA (0, 1 and 2 mM) and 3 levels of NaCl (0, 150 and 300 mM) with 4 replications under controlled greenhouse conditions. Salicylic acid was applied via foliar spray once every two weeks. NaCl was also applied as drench (200 ml per pot) at flowering stage in 3-day intervals. The results showed that salinity of 300 mM NaCl decreased plant height, biomass, number of flowers and chlorophyll index by 52, 59, 100 and 61 percent as compared to control, respectively. Under non-saline conditions, foliar application of SA (2 mM) increased number of flowers, flower diameter, plant height and chlorophyll index by 100, 35, 40 and 39 percent as compared to control, respectively. Plants treated with 1.0 mM SA had the highest leaf area, shoot and root dry weight and biomass at 150 mM salinity. Based on the results of this experiment, foliar application of SA improved growth and ornamental characteristics of Persian petunia under saline and non-saline conditions.
Water photolysis with a cross-linked titanium dioxidenanowire anode (2010)

We report efficient water photolysis using a cross-linked TiO2 nanowire anode containing mixed anatase and rutile phases. Under simulated AM 1.5 G illumination, the peak solar energy conversion efficiency is measured to be 1.05%, a new record for TiO2 photoanodes. A photocurrent density as high as 2.6 mA cm−2 is observed when the film thickness is 22 μm. These observations indicate that the high surface area architecture afforded by the cross-linked TiO2 nanowires enables both long optical path lengths and high photon-to-electron conversion efficiency. We also report photocurrent in the visible range due to sub-band gap absorptions, which is enhanced by up to a factor of 10 when the TiO2 nanowires are coated with gold or silver nanoparticles. This enhancement is observed only in thinner (up to 1 μm) TiO2 nanowire films, however, indicating that the effect stems from enhanced light retention by nanoparticle scattering.
Partial discharge pulse pattern recognition using an inductive inference algorithm (2005)

This paper presents a novel approach in the area of time dependent partial discharge (PD) pulse pattern recognition, to applications based on the inductive learning (decision tree) approach. Different attributes based on pulse shape analysis are used as representative feature vectors that can accurately capture the unique and salient characteristics of the PD pulse shape. In the training phase, a decision tree is developed to relate the pulse shape with the cavity size by using inductive machine learning. The C4.5 machine learning algorithm is deployed to realize the tree using the training data, since it has the capability of inferring the rules and to produce the tree in terms of continuous features. During testing, the cavity size is recognized by means of the rules extracted from the decision tree. The dependency between the features and the classes are examined using the mutual information approach. The proposed algorithm possesses the inherent advantage of explaining the result via the self-created rule base as demonstrated by the results obtained. Those self-created rules can be employed as the basis for applying a fuzzy expert system for the classification of void sizes in an easily interpreted fashion.