gebhart/patrepeval huggingface dataset:
High-resolution airborne imaging spectrometer (1998)

Spectral radiometers and imaging radiometers have been used for decades to provide detailed information about the infrared properties of remote objects. Both of these senors provide complementary information. Even more information can be obtained using a fusion of these two instruments. A spectral imaging radiometer provides data absolutely registered in the spatial, spectral and temporal domain. In this paper we present SARIS, a new spectral imaging radiometer that will operate both from airborne and ground-based platform. SARIS will provide high speed, highly accurate, 16 X 16 spatial radiometric measurements with 1 cm<SUP>-1</SUP> spectral resolution in the 2 to 5 micrometer spectral band. SARIS will measure up to 150 datacubes (a datacube is a complete spatial/spectral measurement) at a spectral resolution of 8 cm<SUP>-1</SUP> and covering the spectral range from 3.5 to 5 micrometer. In this paper we present the mission, technical requirements and conceptual design of SARIS.
Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02) (2010)

The objective of this phase II single-arm study was to evaluate the efficacy and safety of pazopanib, a multi-targeted tyrosine kinase inhibitor, against vascular endothelial growth factor receptor (VEGFR)-1, -2, and -3, platelet-derived growth factor receptor-alpha and -beta, and c-Kit, in recurrent glioblastoma. Patients with < or =2 relapses and no prior anti-VEGF/VEGFR therapy were treated with pazopanib 800 mg daily on 4-week cycles without planned interruptions. Brain magnetic resonance imaging and clinical reassessment were made every 8 weeks. The primary endpoint was efficacy as measured by 6-month progression-free survival (PFS6). Thirty-five GBM patients with a median age of 53 years and median Karnofsky performance scale of 90 were accrued. Grade 3/4 toxicities included leukopenia (n = 1), lymphopenia (n = 2), thrombocytopenia (n = 1), ALT elevation (n = 3), AST elevation (n = 1), CNS hemorrhage (n = 1), fatigue (n = 1), and thrombotic/embolic events (n = 3); 8 patients required dose reduction. Two patients had a partial radiographic response by standard bidimensional measurements, whereas 9 patients (6 at the 8-week point and 3 only within the first month of treatment) had decreased contrast enhancement, vasogenic edema, and mass effect but <50% reduction in tumor. The median PFS was 12 weeks (95% confidence interval [CI]: 8-14 weeks) and only 1 patient had a PFS time > or =6 months (PFS6 = 3%). Thirty patients (86%) had died and median survival was 35 weeks (95% CI: 24-47 weeks). Pazopanib was reasonably well tolerated with a spectrum of toxicities similar to other anti-VEGF/VEGFR agents. Single-agent pazopanib did not prolong PFS in this patient population but showed in situ biological activity as demonstrated by radiographic responses. ClinicalTrials.gov identifier: NCT00459381.
Investigation of the potency of cells from the postimplantation mouse embryo by blastocyst injection: a preliminary report (1978)

Chimaeric conceptuses have been produced by injection of 5 1/2-and 6 1/2-day extra-embryonic ectoderm and 5 1/2-day embryonic and extra-embryonic endoderm into 3 1/2-day mouse blastocysts. Extra-embryonic ectoderm cells contributed only to the ectoplacental cone and/or trophoblast giant cell fractions, reflecting the probable trophectoderm origin of these cells. Proximal (visceral) endoderm cells overlying both the embryonic and extra-embryonic ectoderm contributed cells only to the endoderm of the visceral yolk sac, indicating that the definitive embryonic endoderm has not formed by 5 1/2 days p.c.
A compact and low-loss silicon waveguide crossing for O-band optical interconnect (2014)

Silicon photonics has attracted extensive attention in recent years as a promising solution for next generation high-speed, low energy consumption, and low cost data transmission systems. Although a few experiments indicated board-level and long haul communication capability, major and near-future application of silicon photonics is commonly seen as Ethernet at 100Gb/s and beyond, such as interconnects in data centers, where O-Band (near 1310 nm wavelength) has been standardized for its low fiber dispersion. However, almost all silicon photonics devices demonstrated up to date operate at C-Band (1530 nm to 1560 nm), the fiber loss and erbium amplification window, probably due to the wider availability of lasers and testing apparatus at this wavelength. Typical C-Band devices cannot operate at O-Band, thus the whole device library needs to be redesigned and recalibrated for O-Band applications. In this paper, we present an ultra compact, low loss, and low crosstalk waveguide crossing operating at O-Band. It is designed using the finite difference time domain method coupled with a particle swarm optimization. Device footprint is only 6 μm × 6 μm. The measured insertion loss is 0.19±0.02 dB across an 8-inch wafer. Cross talk is lower than -35 dB. We also report a second waveguide crossing with a 9 μm × 9 μm footprint with 0.017±0.005 dB insertion loss. Finally we summarize the performance of our overall O-Band device library, including low-loss waveguides, high-speed modulators, and photodetectors.
Alternating Ring‐Opening Metathesis Copolymerization by Grubbs‐Type Initiators with Unsymmetrical N‐Heterocyclic Carbenes (2009)

A series of Ru(IV)-alkylidenes based on unsymmetrical imidazolin-2-ylidenes, that is, [RuCl(2){1-(2,4,6-trimethylphenyl)-3-R-4,5-dihydro-(3H)-imidazol-1-ylidene}(CHPh)(pyridin)] (R = CH(2)Ph (5), Ph (6), ethyl (7), methyl (8)), have been synthesized. These and the parent initiators [RuCl(2)(PCy(3)){1-(2,4,6-trimethylphenyl)-3-R-4,5-dihydro-(3H)-imidazol-1-ylidene}(CHC(6)H(5))] (R = CH(2)C(6)H(5) (1), C(6)H(5) (2), ethyl (3)) were used for the alternating copolymerization of norborn-2-ene (NBE) with cis-cyclooctene (COE) and cyclopentene (CPE), respectively. Alternating copolymers, that is, poly(NBE-alt-COE)(n) and poly(NBE-alt-CPE)(n) containing up to 97 and 91% alternating diads, respectively, were obtained. The copolymerization parameters of the alternating copolymerization of NBE with CPE under the action of initiators 1-3 and 5-8 were determined by using both a zero- and first-order Markov model. Finally, kinetic investigations using initiators 1-3, 6, and 7 were carried out. These revealed that in contrast to the 2nd-generation Grubbs-type initiators 1-3 the corresponding pyridine derivatives 6 and 7 represent fast and quantitative initiating systems. Hydrogenation of poly(NBE-alt-COE)(n) yielded a fully saturated, hydrocarbon-based polymer. Its backbone can formally be derived by 1-olefin polymerization of CPE (1,3-insertion) followed by five ethylene units and thus serves as an excellent model compound for 1-olefin polymerization-derived copolymers.
Sucrose analogs: an attractive (bio)source for glycodiversification (2012)

Sucrose is a widespread carbohydrate in nature and is involved in many biological processes. Its natural abundance makes it a very appealing renewable raw material for the synthetic production of high-valued molecules. To further diversify the structure and the inherent properties of these molecules, the access to sucrose analogs is of utmost interest and has historically been widely explored through chemical means. Nature also offers a large panel of sucrose-scaffold derivatives, including phosphorylated or highly substituted phenylpropanoid esters amenable to transformation. Additionally, the use of microorganisms or enzymes could provide an alternative ecologically-compatible manner to diversify sucrose-scaffold derivatives to enable the synthesis of oligo- or polysaccharides, glycoconjugates or polymers that could exhibit original properties for biotechnological applications. This review covers the main biological routes to sucrose derivatives or analogs that are prevalent in nature, that can be obtained via enzymatic processes and the potential applications of such sucrose derivatives in sugar bioconversion, in particular through the engineering of substrates, enzymes or microorganisms.
Comparative cardiovascular actions of verapamil and its major metabolites in the anaesthetised dog (1978)

After intracoronary administration in 12 dogs verapamil exhibited considerably greater vasodilator efficacy than the metabolites nor-verapamil (D 591, N-demethylated form of verapamil), D 617 (N-dealkylated form by removal of the dimethoxyphenylethyl moiety), and D 620 (the N-demethylated analogue of D 617), relative potencies being 1, 0.22, 0.03, and 0.04 respectively. According to their coronary activity equipotent doses of the drugs were administered i.v. in another group of 24 animals and haemodynamic variables were measured. Verapamil exhibited significant effects on LVSP (−17%), systolic, mean and diastolic blood pressures (−18, −20, −24%), cardiac output (+66%), stroke volume (+ 18%), heart rate (+40%), peripheral (−51%), and coronary resistance (−60%), coronary flow (+98%), and P-Q interval (+ 15%, P-Qc+56%). Contractility was not influenced as judged from mean values. D 591 produced significant but smaller haemodynamic effects on coronary flow (+42%), cardiac output (+25%), stroke volume (+ 18%), peripheral (−20%), and coronary resistance (−31%). Heart rate and consequently left ventricular contractility increased gradually with a time effect course different from the other variables. The only significant effects after D 617 were a reduction in contractility (−20%) and an increase in coronary resistance (+ 18%). D 620 exhibited no statistically significant haemodynamic changes. It is concluded that of the metabolites investigated D 591 may partly contribute to the haemodynamic actions of verapamil, whereas D 617 and 620 appear to play no role. None of the metabolites seems to contribute to verapamil's prolongation of nodal conduction.
INDOCYANINE GREEN AND TRYPAN BLUE (2007)

ICG is bound and taken up by RPE cells at concentrations lower than clinically used, and TB is not. Understanding the effects of dyes on ocular tissues leads to more effective and safer dye-assisted vitrectomy protocols, although the experimental setting is different from the clinical situation.
Anticancer Properties of Distinct Antimalarial Drug Classes (2013)

We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductase) inhibitors effected potent inhibition of proliferation with IC50s in the nM- low µM range, whereas a DHODH (dihydroorotate dehydrogenase) and a putative kinase inhibitor displayed no activity. Furthermore, significant synergies were identified with erlotinib, imatinib, cisplatin, dasatinib and vincristine. Cluster analysis of the antimalarials based on their differential inhibition of the various cancer lines clearly segregated the synthetic peroxides OZ277 and OZ439 from the artemisinin cluster that included artesunate, dihydroartemisinin and artemisone, and from the DHFR inhibitors pyrimethamine and P218 (a parasite DHFR inhibitor), emphasizing their shared mode of action. In order to further understand the basis of the selectivity of these compounds against different cancers, microarray-based gene expression data for 85 of the used cell lines were generated. For each compound, distinct sets of genes were identified whose expression significantly correlated with compound sensitivity. Several of the antimalarials tested in this study have well-established and excellent safety profiles with a plasma exposure, when conservatively used in malaria, that is well above the IC50s that we identified in this study. Given their unique mode of action and potential for unique synergies with established anticancer drugs, our results provide a strong basis to further explore the potential application of these compounds in cancer in pre-clinical or and clinical settings.
Molecular Characterization of Genetic Loci Required for Secretion of Exoproducts in <i>Burkholderia pseudomallei</i> (1999)

Previous studies have demonstrated that Burkholderia pseudomallei secretes protease, lipase, and phospholipase C (PLC) into the extracellular milieu, but their mechanisms of secretion and roles in pathogenesis have not been elucidated. In this study, we isolated and characterized 29 transposon mutants unable to secrete protease, lipase, and PLC.
Studies on Hydroxyproline (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on HydroxyprolineArthur A. Patchett and Bernhard WitkopCite this: J. Am. Chem. Soc. 1957, 79, 1, 185–192Publication Date (Print):January 1, 1957Publication History Published online1 May 2002Published inissue 1 January 1957https://pubs.acs.org/doi/10.1021/ja01558a050https://doi.org/10.1021/ja01558a050research-articleACS PublicationsRequest reuse permissionsArticle Views791Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Dynamic Software Product Line Architecture for Prepackaged Expert Analytics: Enabling Efficient Capture, Reuse and Adaptation of Operational Knowledge (2014)

Advanced asset health management solutions blend business intelligence with analytics that incorporate expert operational knowledge of industrial equipment and systems. Key challenges in developing these solutions include: streamlining the capture and prepackaging of operational experts' knowledge as analytic modules, efficiently evolving the modules as knowledge grows, adapting the analytics in the field for diverse operating circumstances and industries, and executing the analytics with high performance in industrial and enterprise software systems. A Quality Attribute Workshop (QAW) was used to elicit and analyze variability at development time and runtime for creating, integrating, evolving, and tailoring reusable analytic modules for ABB/Ventyx asset health solution offerings. Dynamic software product line (DSPL) architecture approaches were then applied in designing an analytics plug in architecture for asset health solutions. This paper describes our approach and experiences in designing the analytics product line architecture and its SME Workbench toolset, and how we achieved significant improvements in speed and flexibility of deploying industrial analytics.
EMG Pattern Analysis and Classification for a Prosthetic Arm (1982)

This paper deals with the statistical analysis and pattern classification of electromyographic signals from the biceps and triceps of a below-the-humerus amputated or paralyzed person. Such signals collected from a simulated amputee are synergistically generated to produce discrete lower arm movements. The purpose of this study is to utilize these signals to control an electrically driven prosthetic or orthotic arm with minimum extra mental effort on the part of the subject. The results show very good separability of classes of movements when a learning pattern classification scheme is used, and a superposition principle seems to hold which may provide a means of decomposition of any composite motion to the six basic primitive motions, e.g., humeral rotation in and out, elbow flexion and extension, and wrist pronation and supination. Since no synergy was detected for the hand movements, different inputs have to be provided for a grip. The method described is not limited by the location of the electrodes. For amputees with shorter stumps, synergistic signals could be obtained from the shoulder muscles. However, the presentation in this paper is limited to bicep-tricep signal classification only.
DEBE PROMOVERSE EL DESARROLLO EMPRENDEDOR EN LOS PROFESIONALES (1990)

EN TODOS LOS NIVELES DE LA SOCIEDAD MEXICANA DEBE REORIENTARSE LA ACTITUD DE LOS PROFESIONALES, QUIENES DEBEN INCURSIONAR EN EL MERCADO DE TRABAJO NO SOLO CON LA IDEA DE SER BUSCADORES DE EMPLEO SINO DE SER PARTICIPES EN LA VIDA PRODUCTIVA COMO GENERADORES DE FUENTES DE TRABAJO, AFIRMO EL DIRECTOR DE LA FACULTAD DE INGENIERIA DE LA UNAM, DANIEL RESENDIZ NUNEZ, DURANTE LA CONFERENCIA FORMACION DE EMPRENDEDORES, DICTADA POR EL DOCTOR RAMON DE LA PENA, RECTOR DEL INSTITUTO TECNOLOGICO DE MONTERREY (ITESM), EN ESTA FACULTAD.
Modification of radiation‐induced acute oral mucositis in the rat (2004)

Curcumin and other components of compound A appeared to be effective in the prevention of radiation-induced oral mucositis. However, the overall effect observed with the combination drug (compound A) appeared greater than additive.
Verzuiling: een eigentijds systeem van sociale controle (1956)

Verzuiling - a typical Dutch word untranslatable in one word - is defined as 'the process in which various ideological groups in one society are included in predominantly organizational systems of social control with a tendency of the ideational values to be dominated by the org and of the org'al domination to be ideologically justified'. On the basis of this definition the verzuiling of the socialist, the Roman-Cath, and the Calvinist groups in Holland are analyzed. Socialist verzuiling is on the decline since WWII. Verzuiling is one of the newer forms of social control in which domination by rational org and domination by traditional ideological control are integrated. In totalitarian systems this tendency has reached an extreme form in which the political party becomes identical with the state bur'tic system. During this process intellectuals have the strongest feeling of the loss of their freedom, as e.g. objectivity in scientific research is thought to be a doubtful or not a value at all. 'Neutral' research in sociology is more and more being rejected by Roman-Cath's and Calvinists in Holland. Verzuiling may also be seen as a shifting of the accent in the relation between means and ends of religious groups. As a process, verzuiling is of such growing importance in Dutch social life that in the Universities there ought to be a possibility to study 'columnology', as etymologically verzuiling means splitting up into zuilen (pillars or columns). L. Turksma.
Q-band high isolation GaAs HEMT switches (2002)

In this paper, we present on-wafer measured results of Q-band GaAs HEMT switches. This work benchmarks the state-of-the-art performance of a SPDT switch with 1.6 dB insertion loss and 50 dB isolation at 44 GHz; a SPQT switch with 3 dB insertion loss and 42 dB isolation at 44 GHz. The SPDT switch has isolation of 30-50 dB over a 41-49 GHz bandwidth. The SPQT switch has isolation of 30-48 dB over a 42-47 GHz bandwidth. This is a 20 dB improvement in isolation over reported Q-band FET switches.
Studies on the Melamine-Formaldehyde Resins (1963)

ブチルエーテル化メラミン樹脂中のメチロール基を定量する目的で研究を行なった。ジオキサンを溶剤に用いてヨード法で行なうと樹脂の析出を防いで定量できることがわかったので, その適用条件を検討しブタノール比色定量法およびリン酸加熱分解法と併用して樹脂の組成を求めた。
Laser-assisted ultrathin bare die packaging: a route to a new class of microelectronic devices (2013)

Ultrathin flip-chip semiconductor die packaging on paper substrates is an enabling technology for a variety of extremely low-cost electronic devices with huge market potential such as RFID smart forms, smart labels, smart tickets, banknotes, security documents, etc. Highly flexible and imperceptible dice are possible only at a thickness of less than 50 μm, preferably down to 10-20 μm or less. Several cents per die cost is achievable only if the die size is ≤ 500 μm/side. Such ultrathin, ultra-small dice provide the flexibility and low cost required, but no conventional technology today can package such die onto a flexible substrate at low cost and high rate. The laser-enabled advanced packaging (LEAP) technology has been developed at the Center for Nanoscale Science and Engineering, North Dakota State University in Fargo, North Dakota, to accomplish this objective. Presented are results using LEAP to assemble dice with various thicknesses, including 350 μm/side dice as thin as 20 μm and less. To the best of our knowledge, this is the first report of using a laser to package conventional silicon dice with such small size and thickness. LEAP-packaged RFID-enabled paper for financial and security applications is also demonstrated. The cost of packaging using LEAP is lower compared to the conventional pick-and-place methods while the rate of packaging is much higher and independent of the die size.
On-the-fly Composition of FPGA-Based SQL Query Accelerators Using a Partially Reconfigurable Module Library (2012)

In this paper, we introduce a novel FPGA-based methodology for accelerating SQL queries using dynamic partial reconfiguration. Query acceleration is of utmost importance in large database systems to achieve a very high throughput. Although common FPGA-based accelerators are suitable to achieve such a high throughput, their design is hard to extend for new operations. Using partial dynamic reconfiguration, we are able to build more flexible architectures which can be extended to new operations or SQL constructs with a very low area overhead on the FPGA. Furthermore, the reconfiguration of a few FPGA frames can be used to switch very fast from one query to the next. In our approach, an SQL query is transformed into a hardware pipeline consisting of partially reconfigurable modules. The assembly of the (FPGA) data path is done at run-time using a static system providing the stream-based communication interfaces to the partial modules and the database management system. More specifically, each incoming SQL query is analyzed and divided into single operations which are subsequently mapped onto library modules and the composed data path loaded on the FPGA. We show that our approach is able to achieve a substantially higher throughput compared to a software-only solution.
Condition monitoring for helicopter data (2002)

In this paper the classical Westland set of empirical accelerometer helicopter data is analyzed with the aim of condition monitoring for diagnostic purposes. The goal is to determine features for failure events from these data, via a proprietary signal processing toolbox, and to weigh these according to a variety of classification algorithms. As regards signal processing, it appears that the autoregressive (AR) coefficients from a simple linear model encapsulate a great deal of information in a relatively few measurements; it has also been found that augmentation of these by harmonic and other parameters can improve classification significantly. As regards classification, several techniques have been explored, among these restricted Coulomb energy (RCE) networks, learning vector quantization (LVQ), Gaussian mixture classifiers and decision trees. A problem with these approaches, and in common with many classification paradigms, is that augmentation of the feature dimension can degrade classification ability. Thus, we also introduce the Bayesian data reduction algorithm (BDRA), which imposes a Dirichlet prior on training data and is thus able to quantify probability of error in an exact manner, such that features may be discarded or coarsened appropriately.