gebhart/patrepeval huggingface dataset:
Quantitative and Temporal Proteome Analysis of Butyrate-treated Colorectal Cancer Cells (2008)

Colorectal cancer is one of the most common cancers in developed countries, and its incidence is negatively associated with high dietary fiber intake. Butyrate, a short-chain fatty acid fermentation by-product of fiber induces cell maturation with the promotion of growth arrest, differentiation, and/or apoptosis of cancer cells. The stimulation of cell maturation by butyrate in colonic cancer cells follows a temporal progression from the early phase of growth arrest to the activation of apoptotic cascades. Previously we performed two-dimensional DIGE to identify differentially expressed proteins induced by 24-h butyrate treatment of HCT-116 colorectal cancer cells. Herein we used quantitative proteomics approaches using iTRAQ (isobaric tags for relative and absolute quantitation), a stable isotope labeling methodology that enables multiplexing of four samples, for a temporal study of HCT-116 cells treated with butyrate. In addition, cleavable ICAT, which selectively tags cysteine-containing proteins, was also used, and the results complemented those obtained from the iTRAQ strategy. Selected protein targets were validated by real time PCR and Western blotting. A model is proposed to illustrate our findings from this temporal analysis of the butyrate-responsive proteome that uncovered several integrated cellular processes and pathways involved in growth arrest, apoptosis, and metastasis. These signature clusters of butyrate-regulated pathways are potential targets for novel chemopreventive and therapeutic drugs for treatment of colorectal cancer.
Fabrication and Properties of Lithium Ceramics (1989)

This book reports on the fabrication and properties of lithium ceramics. The book focuses on features of lithium ceramics which are necessary to support such applications as fusion blankets.
IFN-producing Killer Dendritic Cells Contribute to the Inhibitory Effect of Poly I:C on the Progression of Murine Melanoma (2008)

Toll-like receptor 3 agonist polyinosinic-polycytidilic acid (poly I:C) has been widely used as a potent adjuvant in tumor immunotherapy. In the present study, it was demonstrated that intraperitoneal injection of poly I:C could inhibit lung and liver metastasis of B16 melanoma cells in C57BL/6 mice in natural killer (NK) cells and interferon (IFN)-gamma dependent manner, leading to prolonged survival of the mice. B220 CD11c NK1.1 cells, recently defined as IFN-producing killer dendritic cells (IKDCs) were markedly increased in the spleen, lung, and liver of poly I:C-treated tumor bearing mice, compared with the control group. IFN-gamma induction by poly I:C in this unique NK cell subset indicated its critical contribution in tumor suppression in this model. Meanwhile, results of in vitro culture assay showed that poly I:C synergized with B16 cells could significantly promote IKDCs expansion in lymphocytes from different organs along with IFN-gamma production. Moreover, these ex vivo expanded IKDCs also exerted cytolytic activities against B16 cells and YAC-1 cells as conventional NK cells did. In conclusion, the findings of this study provide new insights into the role of IFN-gamma and IKDCs in the antitumor effect of poly I:C, and will possibly be helpful to explain why poly I:C may work as an adjucant to improve the antitumor effects of innate cells.
Design of an artificial intelligence controller for effective control of engine speed and pump flow according to working condition of an excavator (2002)

This paper explores advanced controller design concepts by combining the fields of artificial intelligence (AI) and automatic control. To accomplish this, the effective AI controller for the working mode control of excavator is designed. The knowledge bases for the controller are established from the human operator's experience and basic engineering knowledge and the operating curves of the engine and pump. And a new gain self-tuning algorithm is proposed for closed loop gain control. The excavator with the controller shows to drive more effectively and efficiently in each working mode.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Les ministres non gaullistes dans les gouvernements de Gaulle et Debré (juin 1958-avril 1962) : techniciens et politiques (2010)

Le dernier gouvernement de la IV e République dirigé par le général de Gaulle en juin 1958 et le premier gouvernement de la V e République de Michel Debré de janvier 1959 comprennent des ministres non gaullistes qui sont soit des politiques soit des techniciens en majorité des hauts fonctionnaires. Dans cette phase de transition, le général de Gaulle a estimé utile d’avoir l’appui des anciens ténors de la IV e République et d’attirer un corps de hauts fonctionnaires soucieux d’efficacité. La cohabitation entre ministres gaullistes et non gaullistes ne fut pas facile. Si les techniciens semblent mieux s’adapter au nouveau régime, se pose la question d’une marginalisation progressive des ministres non gaullistes politiques.
Physical Assessment (1986)

'We (have) emphasised the importance of carrying out a detailed assessment of the needs of each individual resident: this applies with even greater force to the profoundly handicapped.'.
Online enhanced problem-based learning: assessing a blended learning framework (2010)

Learning Management Systems (LMSs) provide learning and teaching technological tools and are employed in many education institutions in Australia and internationally. This paper describes a project in which a generic, institutionally adopted, online LMS was adapted to a postgraduate professional legal education course to blend the online elements with other existing methods of delivery. The rationale of the project was to add to the existing flexible learning mode and create an enhanced student-centred learning environment as well as improved learning outcomes. It explores some of the potential advantages of incorporating online components within a flexibly delivered course which relies heavily on a problem-based learning format. These include opportunities to create “real-life” learning experiences and promote student collaboration while they acquire and strengthen skills of independence, self-reliance and self-management – among the skills students need for lifelong learning which they can apply across disciplines and global legal environments.
Shape of a twin as related to the inelastic forces acting on twinning dislocations in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">YBa</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>7</mml:mn><mml:mi>−</mml:mi><mml:mi>δ</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> (2001)

We investigated with electron microscopy the twin shape in ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{7\ensuremath{-}\ensuremath{\delta}}$ matrix of melt-textured pellets that contained dispersed particles of ${\mathrm{Y}}_{2}{\mathrm{BaCuO}}_{5}$ (Y211). We compared the recorded images with the shape predicted from the thin twin-dislocation theory for three regions (twin tip, root, and intermediate regions). These twin-shape investigations yielded twin-boundary energies ${\ensuremath{\gamma}}_{\mathrm{tw}}=(60.0\ifmmode\pm\else\textpm\fi{}21.0) {\mathrm{m}\mathrm{J}/\mathrm{m}}^{2}$ that agree with values $46.5 {\mathrm{m}\mathrm{J}/\mathrm{m}}^{2}$ obtained by relating twin spacing with local twin-colony size, determined by spacing between $\mathrm{Y}211$ particles for the same samples. Addition of $\mathrm{Pt}$ proves to decrease twin boundary energy to $(26.8\ifmmode\pm\else\textpm\fi{}9.5) {\mathrm{m}\mathrm{J}/\mathrm{m}}^{2}$ as evaluated by the twin shape method and to $18.3 {\mathrm{m}\mathrm{J}/\mathrm{m}}^{2}$ by the interparticle twin-spacing method. The lattice frictional force ${S}_{\mathrm{fr}}$ resisting twining dislocation motion was also estimated from the minimum twin thickness ${h}_{c}$ and twin shape. The estimated frictional force agrees with the limit set by the reported detwinning stress. Both the frictional force and detwinning stress are expected to increase sharply as temperature falls. We then estimated the critical length scale around $250 \mathrm{nm}$ when it will be still energetic to create twins instead of remaining elastically strained and twinless.
High-power singlemode AlGaAs distributed Bragg reflectorlaser diodes operating at 856 nm (1994)

Data are presented describing AlGaAs distributed Bragg reflector (DBR) laser diodes operating at 856 nm with single transverse and longitudinal mode behaviour beyond 270 mW CW. The threshold current of these lasers is 35 mA, with a differential quantum efficiency of 58%. Preliminary lifetest data are presented.
Treatment of Post-Prostatectomy Stress Urinary Incontinence with Periurethral Polytetrafluoroethylene Paste Injection (1994)

Periurethral injection of polytetrafluoroethylene (Teflon) paste was performed to treat moderate to severe stress urinary incontinence following prostatectomy. A total of 20 procedures was performed in 13 men, of whom 8 had previously undergone radical prostatectomy for prostate cancer and 5 had undergone transurethral electrocautery resection of the prostate for bladder outlet obstruction due to benign prostatic hyperplasia. All patients had significant stress urinary incontinence requiring a minimum of 2 pads wet daily. Between 16 and 20 cc polytetrafluoroethylene paste were injected initially transurethrally into the periurethral tissues in the region of the external sphincter. Of the 13 patients 7 underwent a second injection procedure with an additional 12 to 23 cc paste. Three men (23%) experienced a noticeable improvement in continence status, including 1 of 5 patients after transurethral electrocautery resection and 2 of 8 after radical prostatectomy. However, none of these men became completely dry or was able to eliminate completely the use of pads. Of the 13 patients 10 (77%) experienced no detectable improvement in continence status. Seven patients have now successfully undergone implantation of an artificial urinary sphincter without complication. With a minimum followup of 11 months in all patients and a maximum followup of 3 years, none has experienced any clinically detectable long-term side effects related to the polytetrafluoroethylene injection or evidence of particulate migration.
Advances in PET-MRI technology (2011)

Multimodality imaging is the general trend of clinical imaging.PET-CT is one of the most classic and mature multimodality imaging methods and is widely used today.MRI is another kind of conventional imaging method, in contrast to CT, MRI can not only yield images with higher soft-tissue contrast and better spatial resolution but also provide some functional information by special imaging techniques such as MRS.The combination of PET and MRI for simultaneous data acquisition should have far-reaching consequences for clinical and scientific study.This review describes the progress to date and talks about the problems met in the development of PET-MRI and look forward to its potential application.

Key words: 
Positron-emission tomography;  Magnetic resonance imaging;  Tomography, X-ray computed;  Image processing, computer-assisted
Impact of Immunizations with Porcine Reproductive and Respiratory Syndrome Virus on Lymphoproliferative Recall Responses of CD8 <sup>+</sup> T Cells (2004)

The objective of this study was to investigate the immune responses elicited by either a modified-live (MLV) or a killed virus (KV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. Specifically, we investigated the effects of multiple vaccinations on antigen-specific cellular and antibody responses against PRRSV. Twelve sows were obtained from herds with either a history of repeated MLV or KV PRRSV vaccination and a non-vaccinated, PRRSV-negative herd. Within herd, sows were divided into three groups and vaccinated with MLV, KV, or injected with saline. On day 0, 27, and 38, recall responses of peripheral blood mononuclear cells (PBMC) to the parent strains of the vaccines (e.g., MLV-VR2332 or KV-ISUP) were examined. The concentrations of total PRRSV-specific and virus-neutralizing serum antibodies were determined by ELISA and serum neutralization assays. Following immunization, the antigen-specific proliferation of CD8alphabeta(+), CD4(+)CD8alphaalpha(+) T cells in the naive sows was greater than in sows repeatedly vaccinated with KV or MLV. This diminished lymphoproliferative responses of CD8alphabeta(+) and CD4(+)CD8alphaalpha(+) T cells could be partially overcome by heterologous immunization. However, B cell proliferation, PRRSV antibody concentrations and virus neutralizing antibody titers were not enhanced by heterologous immunization and only KV vaccination increased antibody levels in previously immunized (MLV or KV) sows.
Estradiol-17β reduces blood pressure and restores the normal amplitude of the circadian blood pressure rhythm in postmenopausal hypertension (1998)

After menopause, both systolic (SBP) and diastolic (DBP) blood pressure (BP) become higher in women than in men of the same age, suggesting that estrogen deficiency may influence the age-related increase in BP. We studied 30 postmenopausal women (mean age, 55 +/- 5.7 years; time from menopause, 2-5 years) affected by mild hypertension with no target-organ complications by means of 24-h BP monitoring. None of the group were undergoing estrogen replacement therapy or taking antihypertensive drugs. According to a randomized, double-blind protocol, subjects received patches of transdermal estradiol-17beta (E2) or a matched placebo, with crossover after a 7-day washout period. In 12 patients the 24-h peak-to-trough variation in SBP and DBP amounted to less than 10% (nondippers). Administration of E2 significantly decreased 24-h SBP and DBP in the whole cohort (P < .05). Furthermore, E2 restored the expected reduction in BP during nighttime in the nondipper subgroup. It is well known that estrogen replacement therapy protects against the development of both cardiovascular diseases and stroke. Our data suggest that this activity could be attributed, at least in part, to the activity of E2 in preserving physiologic circadian fluctuation of BP.
A Comparison of Signal-to-Noise Ratios for Near-Infrared Detectors (1984)

Five detectors sensitive in the near-Infrared, including two photomultiplier tubes, a silicon photodiode, a silicon photodiode array, and a lead-sulfide photoconductor, are evaluated in terms of signal-to-noise ratios. Theoretical noise and signal calculations are compared to measured noise values and relative responses. The spectral response of the detectors between 700 and 1200 nm is also reported. The relative merits of a particular detector are a function of wavelength, photon flux, and other criteria.
IBM Research TREC 2002 Video Retrieval System. (2002)

In this paper, we describe the IBM Research system for analysis, indexing, and retrieval of video, which was applied to the TREC-2002 video retrieval benchmark. The system explores methods for fully-automatic content analysis, shot boundary detection, multi-modal feature extraction, statistical modeling for semantic concept detection, and speech recognition and indexing. The system supports querying based on automatically extracted features, models, and speech information. Additional interactive methods for querying include multiple-example and relevance feedback searching, cluster, concept, and storyboard browsing, and iterative fusion based on user-selected aggregation and combination functions. The system was applied to all four of the tasks of the video retrieval benchmark including shot boundary detection, concept detection, concept exchange, and search. In this paper, we describe the approaches for each of the tasks and discuss some of the results. 1
Molecularly Protected Bismuth Telluride Nanoparticles: Microemulsion Synthesis and Thermoelectric Transport Properties (2006)

A room-temperature microemulsion synthesis of molecularly capped bismuth telluride nanoparticles with small (average ca. 2.5 nm) diameters is reported (see figure). The use of thioglycolic acid ligands inhibits nanoparticle agglomeration and surface oxidation. Annealing the nanoparticle films to 350 ° C yields a Seebeck coefficient of – 107 μV K–1. The findings are attractive for realizing of high figure of merit thermoelectric materials via nanostructuring control over surface chemistry. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c0495_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Efficacy of LY303366 against Amphotericin B-Susceptible and -Resistant <i>Aspergillus fumigatus</i> in a Murine Model of Invasive Aspergillosis (1998)

LY303366 is a novel antifungal echinocandin with excellent in vitro activity against Aspergillus spp. We compared four doses (1, 2.5, 10, and 25 mg/kg of body weight) of LY303366 with amphotericin B (0.5 to 5 mg/kg) in a temporarily neutropenic murine model of invasive aspergillosis against an amphotericin B-susceptible (AF210) and an amphotericin B-resistant (AF65) Aspergillus fumigatus isolate based on in vivo response. Mice were immunosuppressed with cyclophosphamide (200 mg/kg) and infected 3 days later. Treatment started 18 h after infection and lasted for 10 days. LY303366 was given once daily intravenously for 10 days, and amphotericin B (at 0.5, 2, and 5 mg/kg) was given once daily intraperitoneally for 10 days, or only on days 1, 2, 4, and 7 (at 5 mg/kg). Kidneys and lungs from survivors were cultured on day 11. Control mice in both experiments had 90 to 100% mortality. Amphotericin B at 0.5 mg/kg and LY303366 at 1 mg/kg yielded 10 to 20% survival rates for mice infected with either AF210 or AF65. Amphotericin B at 2 and 5 (both regimens) mg/kg yielded a 70 to 100% survival rate for mice infected with AF210 but a 10 to 30% survival rate for mice infected with AF65 (P = 0.01 to 0.04 compared with AF210). Against AF210 and AF65, LY303366 at 2.5, 10, and 25 mg/kg produced a survival rate of 70 to 80%, which was as effective as amphotericin B for AF210, but superior to amphotericin B for AF65 (P < 0.03 to 0.0006). For AF65, LY303366 at 10 and 25 mg/kg/day was superior to amphotericin B at 2 and 5 mg/kg/day in reducing tissue colony counts (P = 0.01 to 0.003), and for AF210, amphotericin B at 5 mg/kg/day and at 5 mg/kg in four doses was more effective than all four regimens of LY303366 in reducing renal culture counts (P = 0.01 to 0.0001). The present study shows, for the first time, that in vivo resistance of A. fumigatus to amphotericin B exists, although this could not be detected by in vitro susceptibility assays. Furthermore, LY303366 appears to be effective against amphotericin B-susceptible and -resistant A. fumigatus infection in this model and should be further evaluated clinically.
Application of molecular chaperone to increase the expression of soluble human-like collagen in Escherichia coli (2013)

Human-like collagen (HLC) is a soluble recombinant protein expressed in Escherichia coli BL21, but the over-expression of recombinant proteins in host cells often leads tomisfolding and aggregation. In order to increase percent of soluble HLC in total HLC, chaperone was introduced. GroEL system cooperated with GroES was found to be beneficial for the enhancement of HLC solubility, and electrophoresis results showed that chaperone was coordinately co-overproduced with recombinant humanlike collagen to optimize de novo folding.When 2.0 g/L of arabinose was added at the start of cultivation, the production of soluble HLC was increased by 55% in Escherichia coli BL21 3.7 pGro7 compared to its parent strain without carrying chaperone plasmid.
Construction of the General Electric Recording Spectrophotometer* (1938)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. L. Michaelson, "Construction of the General Electric Recording Spectrophotometer*," J. Opt. Soc. Am. 28, 365-371 (1938) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC) (2018)

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for over 85% of all cases. Until recently, chemotherapy - characterized by some benefit but only rare durable responses - was the only treatment option for patients with NSCLC whose tumors lacked targetable mutations. By contrast, immune checkpoint inhibitors have demonstrated distinctly durable responses and represent the advent of a new treatment approach for patients with NSCLC. Three immune checkpoint inhibitors, pembrolizumab, nivolumab and atezolizumab, are now approved for use in first- and/or second-line settings for selected patients with advanced NSCLC, with promising benefit also seen in patients with stage III NSCLC. Additionally, durvalumab following chemoradiation has been approved for use in patients with locally advanced disease. Due to the distinct features of cancer immunotherapy, and rapid progress in the field, clinical guidance is needed on the use of these agents, including appropriate patient selection, sequencing of therapies, response monitoring, adverse event management, and biomarker testing. The Society for Immunotherapy of Cancer (SITC) convened an expert Task Force charged with developing consensus recommendations on these key issues. Following a systematic process as outlined by the National Academy of Medicine, a literature search and panel voting were used to rate the strength of evidence for each recommendation. This consensus statement provides evidence-based recommendations to help clinicians integrate immune checkpoint inhibitors into the treatment plan for patients with NSCLC. This guidance will be updated following relevant advances in the field.
Integrating Process-Oriented and Event-Based Systems (Dagstuhl Seminar 16341) (2017)

This report documents the programme and the outcomes of Dagstuhl Seminar 16341 on "Integrating Process-Oriented and Event-Based Systems", which took place August 21--26, 2016, at Schloss Dagstuhl -- Leibniz Center for Informatics. The seminar brought together researchers and practitioners from the communities that have been established for research on process-oriented information systems on the one hand, and event-based systems on the other hand. By exploring the use of processes in event handling (from the distribution of event processing to the assessment of event data quality), the use of events in processes (from rich event semantics in processes to support for flexible BPM), and the role of events in process choreographies, the seminar identified the diverse connections between the scientific fields. This report summarises the outcomes of the seminar by reviewing the state-of-the-art and outlining research challenges on the intersection of process-oriented and event-based systems.