gebhart/patrepeval huggingface dataset:
Stress Relaxation via Addition–Fragmentation Chain Transfer in High <i>T</i><sub>g</sub>, High Conversion Methacrylate-Based Systems (2012)

To reduce shrinkage stress which arises during the polymerization of crosslinked polymers, allyl sulfide functional groups were incorporated into methacrylate polymerizations to determine their effect on stress relaxation via addition-fragmentation chain transfer (AFCT). Additionally, stoichiometrically balanced thiol and allyl sulfide-containing norbornene monomers were incorporated into the methacrylate resin to maximize the overall functional group conversion and promote AFCT while also enhancing the polymer's mechanical properties. Shrinkage stress and reaction kinetics for each of the various functional groups were measured by tensometry and Fourier-transform infrared (FTIR) spectroscopy, respectively. The glass transition temperature (T(g)) and elastic moduli (E') were measured using dynamic mechanical analysis. When the allyl sulfide functional group was incorporated into dimethacrylates, the polymerization-induced shrinkage stress was not relieved as compared with analogous propyl sulfide-containing resins. These analogous propyl sulfide containing monomers are incapable of undergoing AFCT while having similar chemical structure and crosslink density to the allyl sulfide containing methacrylates. Here, a monomethacrylate monomer that also contains a cyclic allyl sulfide (PAS) was found to increase the crosslinking density nearly 20 times as compared to an analogous monomethacrylate in which the allyl sulfide was replaced with an ethyl sulfide. Despite the much higher crosslink density, the PAS formulation exhibited no concomitant increase in stress. Thiol-norbornene resins were copolymerized in PAS to promote AFCT as well as to synergistically combine the ring opening benefits associated with the thiol-ene reaction. AFCT resulted in a 63% reduction of polymerization stress and a 45°C enhancement of the glass transition temperature in the allyl sulfide-containing thiol-norbornene-methacrylate system compared with rubbery dimethacrylates. When compared with conventional glassy dimethacrylates, this combined system has less than 10% of the typical shrinkage stress level while having similarly excellent mechanical properties.
Haematopoietic stem cell transplantation for the treatment of systemic sclerosis and other autoimmune disorders (2003)

Systemic sclerosis (SSc) with involvement of vital organs has up to 50% 5-year mortality and no treatment is known which changes the natural history. Although components of vascular, immunological and fibrotic processes are involved, drugs such as cyclophosphamide (CY), an alkylating agent and a potent immunosuppressive, have been partially effective in uncontrolled studies. The dose of such agents is limited by the inevitable toxicity on the bone marrow, but this threshold may be superseded by first removing the patient's own haematopoietic stem cells, followed by reconstitution of the marrow after high-dose myeloablative CY or other therapy. This autologous haematopoietic stem cell transplantation (HSCT) technique has been applied to approximately 650 patients with severe autoimmune diseases worldwide, > 100 of whom had SSc. Of these, 75 are included in the Basle registry. Around 70% of patients responded with a significant (> 25%) improvement of the thickened skin and stabilisation of vital organ involvement. Approximately a third achieved a durable remission. The treatment-related mortality was 8.5%. Based on these encouraging Phase I/II study results, several multi-centre, international, prospective randomised Phase III trials are running or being planned. The preliminary data suggest that through such a jolt of heavy immunosuppression, the dysregulated autoaggressive immune system may be re-regulated. It is hypothesised that this results in fewer autoinflammatory and unwanted stimulatory signals to other systems such as vascular endothelium and fibroblasts, and these mechanisms are currently under study.
Structural study of the sugar chains of human leukocyte common antigen CD45 (1993)

The leukocyte cell surface glycoprotein CD45 is a protein tyrosine phosphatase and is involved in signal transduction mediated by the T cell antigen receptor. The asparagine-linked sugar chains were released as oligosaccharides from purified CD45 by hydrazinolysis. Approximately 6 mol of sugar chains was released from 1 mol of CD45. These sugar chains were converted to radioactive oligosaccharides by reduction with NaB3H4 and separated into neutral and acidic fractions by paper electrophoresis. All of the acidic oligosaccharides were converted to neutral ones by digestion with sialidase, indicating that they are sialyl derivatives. Binding of the sialylated oligosaccharides to an SNA-agarose column as well as methylation analysis revealed that the oligosaccharides have only alpha-2,6-linked sialic acid residues. The neutral and sialidase-treated acidic oligosaccharides were fractionated by serial lectin column chromatography followed by Bio-Gel P-4 column chromatography. Structural studies of each oligosaccharide by sequential exo- and endoglycosidase digestion and by methylation analysis revealed that CD45 contains mainly bi-, tri-, and tetraantennary complex-type sugar chains. About 46% of the tetraantennary complex-type sugar chains had the poly(N-acetyllactosamine) groups and 18% of the 2,4-branched triantennary complex-type sugar chains had the fucosyl N-acetyllactosamine group. A portion of the bi- and 2,4-branched triantennary complex-type sugar chains were bisected. In addition to these sugar chains, a small amount of high mannose-type and hybrid-type sugar chains were detected.
Light‐Controlled Propulsion of Catalytic Microengines (2011)

Turn off the light: A white-light source is used to control the propulsion of catalytic microengines powered by the local decomposition of hydrogen peroxide into oxygen and water. The influence of the wavelength of the light and intensity on the fuel conditions provides a remote control over the power of the self-propelled microengines (see picture).
Optical frequency comb spectroscopy (2011)

Optical frequency combs offer enormous potential in the detection and control of atoms and molecules by combining their vast spectral coverage with the extremely high spectral resolution of each individual comb component. Sensitive and multiplexed trace gas detection via cavity-enhanced direct frequency comb spectroscopy has been demonstrated for various molecules and applications; however, previous demonstrations have been confined to the visible and near-infrared wavelength range. Future spectroscopic capabilities are created by developing comb sources and spectrometers for the deep ultraviolet and mid-infrared spectral regions. Here we present a broadband high resolution mid-infrared frequency comb-based Fourier transform spectrometer operating in the important molecular fingerprint spectral region of 2100-3600 cm(-1) (2.8-4.8 microm). The spectrometer, employing a multipass cell, allows simultaneous acquisition of broadband, high resolution spectra (down to 0.0035 cm(-1) of many molecular species at concentrations in the part-per-billion range in less than 1 min acquisition time. The system enables precise measurements of concentration even in gas mixtures that exhibit continuous absorption bands. The current sensitivity, 2 x 10(-8) cm(-1) Hz-1/2 per spectral element, is expected to improve by two orders of magnitude with an external enhancement cavity. We have demonstrated this sensitivity increase by combining cavity-enhanced frequency comb spectroscopy with a scanning Fourier transform spectrometer in the near-infrared region and achieving a sensitivity of 4.7 x 10(-10) cm(-1) Hz(-1/2). A cavity-enhanced mid-infrared comb spectrometer will provide a near real-time, high sensitivity, high resolution, precisely frequency calibrated, broad bandwidth system for many applications.
HNF-1beta mutation affects PKD2 and SOCS3 expression causing renal cysts and diabetes in MODY5 kindred (2012)

We demonstrated that this novel HNF-1β mutation strongly influences the expression of both PKD2, responsible for the formation of the renal cysts, and SOCS3, which is associated with early diabetes onset.
NUMERICAL SIMULATION OF THE TURBULENT FLOW PAST UPWIND YACHT SAILS (2015)

Abstract. The ßow past upwind yacht sails is simulated using the commercial computational ßuids dynamics software FLUENT. The high Reynolds number of the ßows dictates the use of turbulence models. The twoequation models available in FLUENT at the time of this work (k−&quot;, RNG k − &quot; and realizable k − &quot;) are tested thoroughly using the backward facing step problem prior to their application to sail ßows. The backward facing step problem is suitable as the ßow involves complex turbulent behavior that is similar in nature to the ßow past upwind sails. Two nearwall modelling options (wall functions and nearwall zonal model) are included in the tests. The realizable k − &quot; model with wall functions is shown to be the best available method in the pack-age. Simulations of ßow past twodimensional sail sections conÞrm this result. Computations were also carried out for two different mast designs. Solutions of threedimensional ßows past Americas Cup upwind sails were found to be useful for qualitative comparisons. Both 2D and 3D viscous ßow results com-pare favorably to the results calculated by panel methods traditionally used in the sailing industry. 1.
Critical issues in the design and assessment of wind turbine arrays (1982)

Array interference is an important consideration in the design of wind farms. The wake interference model discussed here is essential for the rational design of array geometry and analysis of array performance. Key factors in the design of arrays include wind characteristics and physical characteristics of the site, machine characteristics and wind farm economics. Typical array performance calculations show that for a 36-unit array with 10-diameter downwind and 3-diameter crosswind spacing, the array efficiency is approximately 90% for a site with a 10% turbulence level and with an omnidirectional wind distribution. The economics of the wind farm are directly related to the array efficiency and are discussed for wind farms financed by utilities and by private developers. It is concluded that the optimum array maximizes the cost effectiveness of the wind farm and requires a trade-off between array performance and additional land and site development costs.
Regulation of α7 Integrin Expression during Muscle Differentiation (2003)

Expression of the laminin-binding alpha7 integrin is tightly regulated during myogenic differentiation, reflecting required functions that range from cell motility to formation of stable myotendinous junctions. However, the exact mechanism controlling alpha7 expression in a tissue- and differentiation-specific manner is poorly understood. This report provides evidence that alpha7 gene expression during muscle differentiation is regulated by the c-Myc transcription factor. In myoblasts, alpha7 is expressed at basal levels, but following conversion to myotubes the expression of the integrin is strongly elevated. The increased alpha7 mRNA and protein levels following myogenic differentiation are inversely correlated with c-Myc expression. Transfection of myoblasts with the c-Myc transcription factor down-regulated alpha7 expression, whereas overexpression of Madmyc, a dominant-negative c-Myc chimera, induced elevated alpha7 expression. Functional analysis with site-specific deletions identified a specific double E-box sequence in the upstream promoter region (-2.0 to -2.6 kb) that is responsible for c-Myc-induced suppression of alpha7 expression. DNA-protein binding assays and supershift analysis revealed that c-Myc forms a complex with this double E-box sequence. Our results suggest that the interaction of c-Myc with this promoter region is an important regulatory element controlling alpha7 integrin expression during muscle development and myotendinous junction formation.
Design of Distributed Antenna SystemDeployment for 2100 Mhz (2014)

A lot of schemes are proposed to exploit the transmit diversity. Distributed antenna systems (DAS) constitute one of the most attractive schemes to efficiently achieve the stringent quality of service demands of next generation wireless networks. In this project, it is investigated MISO assisted different transmission techniques used in DAS and the performance of downlink multi-cell DAS in terms of capacity improvement using SINR for different transmission scheme. A system level simulation tool is used to analyze the performance [1]. The aim of this paper is to assess the applicability of a Repeater connected to a Distributed Antenna System (DAS) for improving indoor capacity in UMTS radio network (2100 MHz). A guarantee of sufficient coverage and capacity for In-building areas constitutes a considerable issue in topology planning, because in both links, indoor users produce high interference to the outdoor network due to significant indoor propagation losses. Presented configuration effectively exploits effectively a Repeater system that amplifies the signal from the outdoor network and delivers it for indoor locations through distributed antenna system. Implementation of the analyzed Repeater system is straightforward as it does not require usage of separate carrier. Moreover, any separate scrambling codes do not have to be dedicated either. Conducted measurement campaigns reveal improvement of radio conditions due to Repeater implementation that results in 35% gain of downlink capacity for indoor locations.
Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage (2013)

The association of vitamin D deficiency with higher prevalence, relapse rate and progression of multiple sclerosis (MS) has stimulated great interest in using vitamin D supplementation as a preventative measure and even a therapy for established MS. However, there is a considerable lack of evidence when it comes to an age/developmental stage-dependent efficacy of vitamin D action and a time-window for the most effective prophylactic treatment remains unclear. We studied the effect of vitamin D supplementation in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of MS, at three different developmental stages in rats. Supplementation treatment was initiated: i) prior to gestation and maintained throughout pre- and early postnatal development (gestation and lactation); ii) after weaning, throughout juvenile/adolescence period and iii) in adult age. We observed a marked attenuation of EAE in juvenile/adolescent rats reflected in a less severe CNS inflammation and demyelination, accompanied by a lower amount of IFN-γ producing MOG-specific T cells. Moreover, the cytokine expression pattern in these rats reflected a more anti-inflammatory phenotype of their peripheral immune response. However, the same supplementation regimen failed to improve the disease outcome both in adult rats and in rats treated during pre- and early post-natal development. Our data demonstrate a developmental stage-dependent efficiency of vitamin D to ameliorate neuroinflammation, suggesting that childhood and adolescence should be the target for the most effective preventive treatment.
Frequency domain analysis of nonlinear systems: general theory (1979)

A unified study of the applications of Volterra functional series to nonlinear-system analysis is presented with special emphasis on frequency-domain results which either have not been published before, or where rigour had been lacking. In particular, an in-depth analysis of the harmonic and intermodulation frequency components due to each Volterra kernel of a given order will be presented and explicit formulas which complement those already published will be given. The effects of manipulating various kernels, which need not be symmetric, on the overall response, as well as on the composite kernels will be investigated. These results are then applied to the analysis of dynamical systems described by a system of nonlinear state equations and a read-out map
DNA Binding and Photocleavage in Vitro by New Dirhodium(II) dppz Complexes:  Correlation to Cytotoxicity and Photocytotoxicity (2004)

Two new dirhodium(II) complexes possessing the intercalating dppz ligand (dppz = dipyrido[3,2-a:2',3'-c]phenazine), cis-[Rh(2)(mu-O(2)CCH(3))(2)(dppz)(eta(1)-O(2)CCH(3))(CH(3)OH)](+) (1) and cis-[Rh(2)(mu-O(2)CCH(3))(2)(dppz)(2)](2+) (2), were synthesized and characterized as potential agents for photochemotherapy. Various techniques show that 1 binds to DNA through intercalation, although some aggregation of the complex on the DNA surface is also present. In contrast, 2 does not intercalate between the DNA bases; however, strong hypochromic behavior is observed in the presence of DNA, which can be attributed to intermolecular pi-stacking of 2 enhanced by the polyanion. The apparent DNA binding constants determined using optical titrations are compared to those from dialysis experiments. Both complexes photocleave pUC18 plasmid in vitro under irradiation with visible light (lambda(irr) >or= 395 nm, 15 min), resulting in the nicked, circular form. Greater photocleavage is observed for 1 relative to 2, which may be due to the ability of 1 to intercalate between the DNA bases. The cytotoxicity toward human skin cells (Hs-27) measured as the concentration at which 50% cell death is recorded, LC(50), was found to be 135 +/- 8 microM for 2 in the dark (30 min), which is significantly lower than those of 1 (LC(50) = 27 +/- 2 microM) and Rh(2)(O(2)CCH(3))(4) (LC(50) = 15 +/- 2 microM). Irradiation of cell cultures containing 1 and Rh(2)(O(2)CCH(3))(4) with visible light (400-700 nm, 30 min) has little effect on their cytotoxicity, with LC(50) values of 21 +/- 3 and 13 +/- 2 microM, respectively. Interestingly, a 3.4-fold increase in the toxicity of 2 is observed when the cell cultures are irradiated (400-700 nm, 30 min), resulting in LC(50) = 39 +/- 1 microM. The greater toxicity of 1 compared to 2 in the dark may be related to the ability of the former compound to intercalate between the DNA bases. The lower cytotoxicity of 2, together with its significantly greater photocytotoxicity, makes this complex a potential agent for photodynamic therapy (PDT). These results suggest that intercalation or strong DNA binding may not be a desirable property of a potential PDT agent.
Identification of <i>Colletotrichum</i> Species Responsible for Anthracnose and Root Necrosis of Strawberry in Israel (1997)

ABSTRACT Strawberry anthracnose was observed for the first time in Israel in 1995. The disease reached epidemic proportions in Israeli nurseries and production fields in 1995 and 1996. Using morphological and cultural characteristics, the species responsible for anthracnose was identified as Colletotrichum acutatum. A reliable semi-selective medium, amended with iprodione and lactic acid, was used to isolate the fungus from infected tissues. In addition, C. acutatum was subsequently isolated from necrotic roots of stunted, chlorotic plants that exhibited no symptoms of anthracnose. High levels of the pathogen from naturally infested field soil and perlite growth substrate were quantified from the rhizosphere of diseased plants on the iprodione-amended medium. Both foliar- and rootinfecting isolates were equally pathogenic to strawberry, causing 95 to 100% plant mortality, when inoculated on roots and foliage. In complementation (heterokaryon) tests using nitrate nonutilizing mutants, 113 out of 115 isolates from different plant parts and locations belonged to a single vegetative compatibility group. Arbitrarily primed polymerase chain reaction of genomic DNA using four repetitive-motif primers produced nearly uniform amplified DNA banding patterns for 141 of the Israeli strawberry isolates from different sites, plots, plant tissues, and cultivars. When compared to reference isolates from the US, these band patterns suggested that a single introduction of C. acutatum was responsible for strawberry anthracnose on foliage and necrosis of roots in Israel.
Spectral domain optical coherence tomography with balanced detection using single line-scan camera and optical delay line (2015)

We propose a spectral domain optical coherence tomography (SD-OCT) system that uses a single line-scan detection scheme for balanced detection. Two phase-opposed spectra, generated by two optical fiber couplers, were detected by using a spectrometer with fast optical switching. A 2.69 km optical fiber was introduced to provide a proper time delay to prevent phase errors caused by the difference in measurement time between the two opposing spectra and unstable output voltages for controlling the galvano-scanner. Hence, a phase difference of π was obtained between the spectra over the sample depth without a phase error, which improved sensitivity by approximately 6 dB compared to that of conventional SD-OCT. We directly showed and compared the OCT images before and after applying the proposed balanced detection method in a phantom and in vivo sample.
Quantification of the Detrimental Effect of a Single Primer-Template Mismatch by Real-Time PCR Using the 16S rRNA Gene as an Example (2008)

We investigated the effects of internal primer-template mismatches on the efficiency of PCR amplification using the 16S rRNA gene as the model template DNA. We observed that the presence of a single mismatch in the second half of the primer extension sequence can result in an underestimation of up to 1,000-fold of the gene copy number, depending on the primer and position of the mismatch.
[Multicystic renal oncocytoma]. (1991)

The cystic variant of renal oncocytoma was defined by Ogden et al. (1986), who described a single case. A further case is described in the present communication, with notes on the clinical presentation, aspiration cytology, and histology of the surgical specimen. Follow-up over 3 years has been uneventful.
The Utility of Flexible Endoscopy During Advanced Laparoscopy (2003)

Advanced laparoscopic techniques have continued to grow in prevalence for the treatment of gastrointestinal surgical conditions. The field of flexible endoscopy has also continued to increase the boundaries of its capabilities with the advent of purely flexible endoscopic techniques, such as in the treatment of gastrointestinal reflux disease. This article illustrates how flexible endoscopy can be used in combination with laparoscopy in a diverse number of operations in the human foregut and hindgut, such as reflux operations, esophageal myotomies, gastric resections, peptic ulcer operations, colon resections, and pancreatic pseudocyst operations. These examples of the utility of flexible endoscopy during laparoscopy show the marriage of these two disciplines. To be able to adequately use flexible endoscopy during laparoscopy, the surgeon will need to be skilled in flexible endoscopy, and the best way to maintain those skills is to use the flexible endoscopy in one's daily practice.