gebhart/patrepeval huggingface dataset:
Millimeter wave mobile access system with intelligent antenna and radio on fiber (2005)

For any wireless network based on mm-wave radio systems to be viable, the cost of the infrastructure must be much lower than is currently the case. One approach that promises this cost reduction is the radio over fiber, where radio signals at the carrier frequency are delivered over an optical network to the radio access point. Benefits of this centralized approach are that expensive and delicate pieces of equipment can be located in a beginning environment and costs can be shared between a number of radio access point. However, the integration of such systems is conditioned by the development of low cost radio components, antennas, the packaging as well as the optic/radio transductors. The paper explores therefore the areas of strategic importance in integration of new antenna array topologies, which are appropriated for use as a building block for the millimeter wave fiber wireless system that employs an intelligent multi-beam antenna where the direction of each sharp beam can be adoptively controlled. Thereby, the objective of truly monolithic array with integrated planar antennas and phase shifters was the driving force behind the development of the aperture coupled patch element, which is especially relevant for these systems. The effectiveness of this antenna array has been experimentally confirmed. Finally, it is worthy to note that the small wavelengths allow miniaturize of the size of components such as antennas which are very important for portable sets as well as base station (BS) facilities, which need to be readily installed.
Ion assisted deposition of oxynitrides of aluminum and silicon (1989)

Optical thin films of nitrides, oxynitrides, and oxides of aluminum and silicon were deposited using ion assisted deposition. Coatings were deposited by evaporation of either AlN or Si with simultaneous bombardment with 300-eV ions of nitrogen, oxygen, or a mixture of oxygen and nitrogen. The chemical composition of the coatings was varied by varying the gas mixture in the ion beam, making it possible to vary the index of refraction of the coatings during deposition from 1.44 to 2.1 in the case of silicon oxynitrides, and 1.62 to 2.1 in the case of aluminum oxynitrides. Optical properties and environmental stability of the coatings were examined. Coatings are stable under severe conditions of humidity and temperature.
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs (2003)

The mitochondrial pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid (FA) synthesis. Knowledge of the mechanisms that regulate PDC activity is important, because PDC inactivation is crucial for glucose conservation when glucose is scarce, whereas adequate PDC activity is required to allow both ATP and FA production from glucose. The mechanisms that control mammalian PDC activity include its phosphorylation (inactivation) by a family of pyruvate dehydrogenase kinases (PDKs 1-4) and its dephosphorylation (activation, reactivation) by the pyruvate dehydrogenase phosphate phosphatases (PDPs 1 and 2). Isoform-specific differences in kinetic parameters, regulation, and phosphorylation site specificity of the PDKs introduce variations in the regulation of PDC activity in differing endocrine and metabolic states. In this review, we summarize recent significant advances in our knowledge of the mechanisms regulating PDC with emphasis on the PDKs, in particular PDK4, whose expression is linked with sustained changes in tissue lipid handling and which may represent an attractive target for pharmacological interventions aimed at modulating whole body glucose, lipid, and lactate homeostasis in disease states.
Effects of Antioxidants on the Oxidative Susceptibility of Low-Density Lipoprotein. (1997)

An important event in the pathogenesis of atherosclerosis is believed to be the oxidative modification of low-density lipoprotein (LDL) initiated by a free radical-driven lipid peroxidation process. Vitamin E acts as a lipophilic chain-breaking antioxidant, while water-soluble chain-breaking antioxidants such as vitamin C or uric acid suppress the oxidation of LDL initiated by aqueous radicals. In this study, we established a new method of measuring the lag time of inhibited lipid peroxidation using the lipophilic azo radical initiator V-70:2-2'-azobis(4-methoxy-2,4-dimethylvaleronitrile) and investigated in vitro the susceptibility of LDL to oxidation using this method when lipid- and water-soluble antioxidants were added. When the lipid-soluble antioxidant, vitamin E, was added to LDL, the lag time was extended whereas a higher dose of vitamin E led to a shortened lag time of V-70-induced lipid peroxidation in LDL. These results suggest that vitamin E radicals (tocopheroxyl radicals) act as prooxidants during the autoxidation of LDL. It was also shown that the shortened lag time induced by higher doses of vitamin E was restored when lipid- and water-soluble antioxidants were added simultaneously, which suggests that vitamin E radicals derived from vitamin E are subsequently reduced by vitamin C to regenerate vitamin E. Thus, the interaction between lipid- and water-soluble antioxidants provides an important function in maintaining LDL resistance to oxidation.
Role for Amino Acids <sub>212</sub> KLR <sub>214</sub> of Ebola Virus VP40 in Assembly and Budding (2007)

Ebola virus VP40 is able to produce virus-like particles (VLPs) in the absence of other viral proteins. At least three domains within VP40 are thought to be required for efficient VLP release: the late domain (L-domain), membrane association domain (M-domain), and self-interaction domain (I-domain). While the L-domain of Ebola VP40 has been well characterized, the exact mechanism by which VP40 mediates budding through the M- and I-domains remains unclear. To identify additional domains important for VP40 assembly/budding, amino acids (212)KLR(214) were targeted for mutagenesis based on the published crystal structure of VP40. These residues are part of a loop connecting two beta sheets in the C-terminal region and thus are potentially important for overall structure and/or oligomerization of VP40. A series of alanine substitutions were generated in the KLR region of VP40, and these mutants were examined for VLP budding, intracellular localization, and oligomerization. Our results indicated that (i) (212)KLR(214) residues of VP40 are important for efficient release of VP40 VLPs, with Leu213 being the most critical; (ii) VP40 KLR mutants displayed altered patterns of cellular localization compared to that of wild-type VP40 (VP40-WT); and (iii) self-assembly of VP40 KLR mutants into oligomers was altered compared to that of VP40-WT. These results suggest that (12)KLR(214) residues of VP40 are important for proper assembly/oligomerization of VP40 which subsequently leads to efficient budding of VLPs.
Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation. (1997)

Here we report on investigation of the role of the POU domain genes Skin-1a/i (Skn-1a/i/Epoc/Oct-11) and Testes-1 (Tst-1/Oct-6/SCIP) in epidermis where proliferating basal keratinocytes withdraw from the cell cycle, migrate suprabasally, and terminally differentiate to form a multilayered, stratified epithelium. The expression of the Skn-1a/i and Tst-1 genes is linked to keratinocyte differentiation in vivo and in vitro, whereas the ubiquitous POU domain factor Oct-1 is expressed highly in both proliferating and post-mitotic keratinocytes. Analysis of Skn-1a/i gene-deleted mice reveals that the Skn-1a/i gene modulates the pattern of expression of the terminal differentiation marker loricrin and inhibits expression of genes encoding markers of the epidermal keratinocyte wounding response. Although epidermis from Tst-1 gene-deleted mice develops normally, epidermis from mice deleted for both Skn-1a/i and Tst-1 is hyperplastic and fails to suppress expression of K14 and Spr-1 in suprabasal cells when transplanted onto athymic mice. This suggests that Skn-1a/i and Tst-1 serve redundant functions in epidermis. Therefore, at least two POU domain genes, Skn-1a/i and Tst-1, serve both distinct and overlapping functions to regulate differentiation of epidermal keratinocytes during normal development and wound healing.
Composition of Partially Observable Services Exporting their Behaviour (2009)

In this paper we look at the problem of composing services that export their behavior in terms of a transition system, characterizing the choices of actions given to a client at each point in time. The composition consists of synthesizing an orchestrator that coordinates the available services so as to mimic the desired target service asked by the client. Specifically, in this paper we study the "conformant form" of the problem, where available services are partially controllable and partially observable, and hence, the orchestrator has to make its decisions exploiting the observations made so far only. We give a sound and complete procedure to synthesize the orchestrator in such case, and characterize the computational complexity of the problem. The procedure is based on working with belief (or knowledge) states, a standard technique to tackle conformant planning. Moreover we show that, although in general unavoidable, the powerset construction at the base of the belief state approach can be delegated to the symbolic manipulations of the game-structure model checking tool (TLV), which can be used to efficiently implement the orchestrator synthesis procedure.
Effect of Cholesterol Depletion on Exocytosis of Alveolar Type II Cells (2006)

Alveolar epithelial type II cells secrete lung surfactant via exocytosis. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) are implicated in this process. Lipid rafts, the cholesterol- and sphingolipid-rich microdomains, may offer a platform for protein organization on the cell membrane. We tested the hypothesis that lipid rafts organize exocytotic proteins in type II cells and are essential for the fusion of lamellar bodies, the secretory granules of type II cells, with the plasma membrane. The lipid rafts, isolated from type II cells using 1% Triton X-100 and a sucrose gradient centrifugation, contained the lipid raft markers, flotillin-1 and -2, whereas they excluded the nonraft marker, Na+-K+ ATPase. SNAP-23, syntaxin 2, and VAMP-2 were enriched in lipid rafts. When type II cells were depleted of cholesterol, the association of SNAREs with the lipid rafts was disrupted and the formation of fusion pore was inhibited. Furthermore, the cholesterol-depleted plasma membrane had less ability to fuse with lamellar bodies, a process mediated by annexin A2. The secretagogue-stimulated secretion of lung surfactant from type II cells was also reduced by methyl-beta-cyclodextrin. When the raft-associated cell surface protein, CD44, was cross-linked using anti-CD44 antibodies, the CD44 clusters were observed. Syntaxin 2, SNAP-23, and annexin A2 co-localized with the CD44 clusters, which were cholesterol dependent. Our results suggested that lipid rafts may form a functional platform for surfactant secretion in alveolar type II cells, and raft integrity was essential for the fusion between lamellar bodies with the plasma membrane.
[Endoventricular patch-plasty for reconstruction of ventricular geometry and pump function in myocardial aneurysm]. (1996)

This report deals with the first experience with endoventricular patch plasty in patients suffering from left ventricular aneurysm. The early postoperative results in 18 patients operated upon during January and May 1995 are encouraging. All patients survived the procedure. In contrast to patients operated on according to a linear resection technique the postoperative outcome and the early results are much better with this technique. We recommend the endoventricular patch plasty on a beating heart.
Fabrication of Patterned Concave Microstructures by Inkjet Imprinting (2015)

Concave microstructures such as microwells and microgrooves are widely utilized in fields such as biochips, microfluidics, and functional devices. Previously, concave microstructure fabrication was mostly based on laser etching or lithography which is either costly or of multisteps. The inkjet etching method is a direct structuring technique, but limited by its inherent transverse ink diffusion that leads to low feature resolution. Nanoimprint lithography can reach submicro and even nano ranges, whereas an elaborate template is needed. Thus, it is still a challenge to realize controllable fabrication of concave microstructures in large areas with high efficiency and resolution. Here, a template‐free strategy to fabricate concave microstructures with high resolution by inkjet imprinting is provided. In this method, a sacrificial ink is inkjet‐printed onto a precured viscoelastic surface and imprints its shapes to construct concave microstructures. The morphology of the microstructures could be adjusted by controlling the interaction between the two immiscible phases. The microwells/microgrooves could be used to pattern single cells and functional materials such as optical, electronic, and magnetic nanoparticles. These results will open a new pathway to fabricate concave microstructures and broaden their applications in various functional devices.
No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers (2009)

Lacosamide is a new antiepileptic drug for adjunctive treatment of adult partial-onset seizures. Two open-label, multiple-dose clinical trials were conducted to evaluate the potential for pharmacokinetic interaction between lacosamide and carbamazepine. The influence of carbamazepine on lacosamide pharmacokinetics (trial A) and lacosamide on carbamazepine pharmacokinetics (trial B) was investigated in 19 (trial A) and 18 (trial B) healthy male participants. Trial A participants received lacosamide 200 mg bid alone and with carbamazepine 200 mg bid. Trial B participants received carbamazepine 200 mg bid alone and with lacosamide 200 mg bid. Pharmacokinetic parameters, area under the concentration-time curve during a dosage interval at steady state (AUC(tau,ss)), and maximum steady-state plasma drug concentration during a dosage interval (C(max,ss)) of lacosamide, carbamazepine, and carbamazepine-10,11-epoxide were measured and compared for each drug alone and together. The AUC(tau,ss) and C(max,ss) point estimates (combined vs sole treatment) showed relative bioavailability of approximately 100% for both drugs. All 90% confidence intervals of AUC(tau,ss) and C(max,ss) were within the generally accepted bioequivalence ranges of 80% to 125%. No changes in rate or extent of absorption or terminal half-life were observed. These results suggest that lacosamide and carbamazepine have a low potential for pharmacokinetic drug-drug interaction in clinical use.
Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomib (2009)

This clinical trial was conducted to determine the safety and efficacy of bortezomib retreatment in patients with multiple myeloma (MM) who had previously responded to bortezomib. Patients with progressive MM who had previously tolerated bortezomib as a single agent or in combination with other drugs, with a minimum of partial response (PR; >or=50% M-protein reduction) for >or=4 months, who had not received intervening MM therapy, were retreated with bortezomib (days 1, 4, 8, and 11 of a 21-day cycle) with a starting dose being the dose at which the patient ended the initial treatment. Patients were allowed to receive bortezomib on retreatment in combination with dexamethasone, thalidomide, or doxorubicin. Thirty-two patients received bortezomib retreatment (most with added dexamethasone). The median treatment-free interval (last dose of initial bortezomib treatment to first dose of retreatment) was 9.9 (range 2.5-34.0) months. The median duration of retreatment was 2.8 (<1-7.9) months; median total duration of bortezomib treatment was 6.7 (2.5-19.8) months. Based on the investigators' assessment of best response, the overall response rate (complete plus PR) was 50%. The median time from start of retreatment to progressive disease (PD) was 6.6 (95% confidence interval: 5.1-9.6) months. Thirteen patients (41%) experienced PN; bortezomib-related SAEs were reported in four patients. Retreatment with bortezomib alone or in combination is effective and well tolerated in patients with MM who have responded to their initial bortezomib treatment.
LTE/LTE-A Random Access for Massive Machine-Type Communications in Smart Cities (2017)

Massive MTC over cellular networks is expected to be an integral part of wireless smart city applications. The LTE/LTE-A technology is a major candidate for provisioning of MTC applications. However, due to the diverse characteristics of payload size, transmission periodicity, power efficiency, and QoS requirement, MTC poses huge challenges to LTE/LTE-A technologies. In particular, efficient management of massive random access is one of the most critical challenges. In the case of massive random access attempts, the probability of preamble collision drastically increases, and thus the performance of LTE/LTE-A random access degrades sharply. In this context, this article reviews the current state-of-the-art proposals to control massive random access of MTC devices in LTE/LTE-A networks. The proposals are compared in terms of five major metrics: access delay, access success rate, power efficiency, QoS guarantee, and the effect on HTC. To this end, we propose a novel collision resolution random access model for massive MTC over LTE/LTE-A. Our proposed model basically resolves the preamble collisions instead of avoidance and targets the management of massive and bursty access attempts. Simulations of our proposed model show huge improvements in random access success rate compared to the standard slotted-Aloha- based models. The new model can also coexist with existing LTE/LTE-A MAC protocol and ensure high reliability and time-efficient network access.
REMARKS ON TERMINATION OF TEN YEARS OF SERVICE ON THE AMERICAN BOARD OF PLASTIC SURGERY, MAY 1957 (1958)

Plastic and Reconstructive Surgery and the Transplantation Bulletin: February 1958 - Volume 21 - Issue 2 - p 150-151
Hydrophobic as Well as Charged Residues in Both MEK1 and ERK2 Are Important for Their Proper Docking (2001)

Docking between MEK1 and ERK2 is required for their stable interaction and efficient signal transmission. The MEK1 N terminus contains the ERK docking or D domain that consists of conserved hydrophobic and basic residues. We mutated the hydrophobic and basic residues individually and found that loss of either type reduced MEK1 phosphorylation of ERK2 in vitro and its ability to bind to ERK2 in vivo. Moreover, ERK2 was localized in both the cytoplasm and the nucleus when co-expressed with MEK1 that had mutations in either the hydrophobic or the basic residues. We then identified two conserved hydrophobic residues on ERK2 that play roles in docking with MEK1. Mutating these residues to alanine reduced the interaction of ERK2 with MEK1 in cells. These mutations also reduced the phosphorylation of MEK1 by ERK2 but had little effect on phosphorylation of MBP by ERK2. Finally, we generated docking site mutants in ERK2-MEK1 fusion proteins. Although the mutation of the MEK1 D domain significantly reduced ERK2-MEK1 activity, mutations of the putatively complementary acidic residues and hydrophobic residues on ERK2 did not change its activity. However, both types of mutations decreased the phosphorylation of Elk-1 caused by ERK2-MEK1 fusion proteins. These findings suggest complex interactions of MEK1 D domains with ERK2 that influence its activation and its effects on substrates.
Effect of Addition of Bories on Hot-pressin of Coke (1979)

コークス粉末に11種類のホウ化物を添加し, 圧力200kg/cm2, 温度2100℃, 保持時間30分の条件で加圧焼成した. そして, それらのホウ化物がコークスの焼結及び黒鉛化に与える影響について調べた. その結果, すべてのホウ化物はコークスの焼結及び黒鉛化に効果を与えていることが分った. 焼結効果の大なホウ化物はVB2, CrB2, CrB, Mo2B5, ZrB12及びLaB6であり, コークスの黒鉛化効果の大なものはCrB2及びZrB12であった. コークスの黒鉛化促進作用はホウ化物中の一部のホウ素のコークスへの拡散によるものと考えられた. その際, IVa及びVa族のニホウ化物は一部のホウ素を失い炭化物を, またVIa族のニホウ化物は低ホウ素含有化合物を生成することが分った.
A self-organizing reasoning neural network (2002)

In this paper, the design of the feedforward neural network is formulated as a Bayesian-Gaussian reasoning problem. The output of the network is an optimal solution of the a posteriori probability density function. The parameters of the network can be set immediately when the training data are known. The self-organizing ability of the network can also be easily designed based on the reasoning model, thus even when the training samples become increasingly large, the network is able to optimize its parameters in an optimal way. Simulation shows that the reasoning neural network is comparable to or better than the well-known BP network in nonlinear stochastic prediction problems, and the self-organizing neural network is superior to the fixed parameter network in performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Potential Protective Effect of Long-Term Therapy with <i>Xuezhikang</i> on Left Ventricular Diastolic Function in Patients with Essential Hypertension (2009)

Long-term therapy with Xuezhikang improved LV diastolic function, probably mediated through antifibrotic and anti-inflammatory effects and independent of blood pressure and lipid profiles in patients with essential hypertension.
Compliant MEMS and their use in optical components (2002)

We have developed a new branch of MEMS devices that use a very compliant material for the bending/twisting member. This use of an elastomer suspension system significantly widens the design and performance spaces for MEMS devices. We have designed several new microoptical devices based on this new MEMS platform and have gone through prototype development on the first of these new designs, a tunable Fabry-Perot. This new MEMS tunable filter establishes a new state of the art performance level for tunability and finesse.
Regulation of groE expression in Bacillus subtilis: the involvement of the sigma A-like promoter and the roles of the inverted repeat sequence (CIRCE) (1995)

To study the regulatory mechanism controlling the heat-inducible expression of Bacillus subtilis groE, two regulatory elements, the sigma A-like promoter and the inverted repeat (IR [CIRCE]) in the control region, were characterized. The groE promoter was shown to be transcribed by the major RNA polymerase under both heat shock and non-heat shock conditions. The IR was found to have two functions. (i) It ensures the fast turnover of the groE transcript, and (ii) it serves as an operator. This IR acts as a negative heat shock regulatory element, since deletion of this sequence resulted in high-level expression of groE even at 37 degrees C. Although this IR is present in the 5' untranslated region of the groE transcript, groE transcripts under heat shock and non-heat shock conditions showed similar in vivo half-lives of 5 min. This rapid turnover at 37 degrees C requires the presence of the IR. Without the IR, the groE transcript showed a longer half-life of 17 min. Increasing the distance between the groE transcription start site and the IR systematically by inserting nucleotide sequences from 5 to 21 bp in length resulted in a gradual abolition of the negative regulatory effect mediated by the IR. This effect was not due to a significant change in transcript stability or the transcription start site and is consistent with the model that this IR serves as an operator.