gebhart/patrepeval huggingface dataset:
Low‐dose anti‐<scp>CD</scp>20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study (2013)

Low doses of the humanized anti-CD20 monoclonal antibody, veltuzumab, were evaluated in 41 patients with immune thrombocytopenia (ITP), including 9 with ITP ≤1 year duration previously treated with steroids and/or immunoglobulins, and 32 with ITP >1 year and additional prior therapies. They received two doses of 80-320 mg veltuzumab 2 weeks apart, initially by intravenous (IV) infusion (N = 7), or later by subcutaneous (SC) injections (N = 34), with only one Grade 3 infusion reaction and no other safety issues. Thirty-eight response-assessable patients had 21 (55%) objective responses (platelet count ≥30 × 10(9) /l and ≥2 × baseline), including 11 (29%) complete responses (CRs) (platelet count ≥100 × 10(9) /l). Responses (including CRs) occurred with both IV and SC administration, at all veltuzumab dose levels, and regardless of ITP duration. Responders with ITP ≤1 year had a longer median time to relapse (14·4 months) than those with ITP >1 year (5·8 months). Three patients have maintained a response for up to 4·3 years. SC injections resulted in delayed and lower peak serum levels of veltuzumab, but B-cell depletion occurred after first administration even at the lowest doses. Eight patients, including 6 responders, developed anti-veltuzumab antibodies following treatment (human anti-veltuzumab antibody, 19·5%). Low-dose SC veltuzumab appears convenient, well-tolerated, and with promising clinical activity in relapsed ITP.(Clinicaltrials.gov identifier: NCT00547066.).
A Visual Reporter System for Virus-Induced Gene Silencing in Tomato Fruit Based on Anthocyanin Accumulation     (2009)

Virus-induced gene silencing (VIGS) is a powerful tool for reverse genetics in tomato (Solanum lycopersicum). However, the irregular distribution of the effects of VIGS hampers the identification and quantification of nonvisual phenotypes. To overcome this limitation, a visually traceable VIGS system was developed for fruit, comprising two elements: (1) a transgenic tomato line (Del/Ros1) expressing Antirrhinum majus Delila and Rosea1 transcription factors under the control of the fruit-specific E8 promoter, showing a purple-fruited, anthocyanin-rich phenotype; and (2) a modified tobacco rattle virus VIGS vector incorporating partial Rosea1 and Delila sequences, which was shown to restore the red-fruited phenotype upon agroinjection in Del/Ros1 plants. Dissection of silenced areas for subsequent chemometric analysis successfully identified the relevant metabolites underlying gene function for three tomato genes, phytoene desaturase, TomloxC, and SlODO1, used for proof of concept. The C-6 aldehydes derived from lipid 13-hydroperoxidation were found to be the volatile compounds most severely affected by TomloxC silencing, whereas geranial and 6-methyl-5-hepten-2-one were identified as the volatiles most severely reduced by phytoene desaturase silencing in ripening fruit. In a third example, silencing of SlODO1, a tomato homolog of the ODORANT1 gene encoding a myb transcription factor, which regulates benzenoid metabolism in petunia (Petunia hybrida) flowers, resulted in a sharp accumulation of benzaldehyde in tomato fruit. Together, these results indicate that fruit VIGS, enhanced by anthocyanin monitoring, can be a powerful tool for reverse genetics in the study of the metabolic networks operating during fruit ripening.
Automatic Adaption of the Sampling Frequency for Detailed Performance Analysis (2017)

One of the most urgent challenges in event based performance analysis is the enormous amount of collected data. Combining event tracing and periodic sampling has been a successful approach to allow a detailed event-based recording of MPI communication and a coarse recording of the remaining application with periodic sampling. In this paper, we present a novel approach to automatically adapt the sampling frequency during runtime to the given amount of buffer space, releasing users to find an appropriate sampling frequency themselves. This way, the entire measurement can be kept within a single memory buffer, which avoids disruptive intermediate memory buffer flushes, excessive data volumes, and measurement delays due to slow file system interaction. We describe our approach to sort and store samples based on their order of occurrence in an hierarchical array based on powers of two. Furthermore, we evaluate the feasibility as well as the overhead of the approach with the prototype implementation OTFX based on the Open Trace Format 2, a state-of-the-art Open Source event trace library used by the performance analysis tools Vampir, Scalasca, and Tau.
Virus templated metallic nanoparticles (2010)

Plant viruses are considered as nanobuilding blocks that can be used as synthons or templates for novel materials. Cowpea mosaic virus (CPMV) particles have been shown to template the fabrication of metallic nanoparticles by an electroless deposition metallization process. Palladium ions were electrostatically bound to the virus capsid and, when reduced, acted as nucleation sites for the subsequent metal deposition from solution. The method, although simple, produced highly monodisperse metallic nanoparticles with a diameter of ca. ≤35 nm. CPMV-templated particles were prepared with cobalt, nickel, iron, platinum, cobalt-platinum and nickel-iron.
Progress in Polycrystalline Thin-Film Cu(In,Ga)<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mtext>Se</mml:mtext><mml:mtext>2</mml:mtext></mml:msub></mml:mrow></mml:math>Solar Cells (2010)

For some time, the chalcopyrite semiconductor CuInSe 2 and its alloy with Ga and/or S [Cu(InGa)Se 2 or Cu(InGa)(Se,S) 2 ], commonly referred as CIGS, have been leading thin-film material candidates for incorporation in high-efficiency photovoltaic devices. CuInSe 2 -based solar cells have shown long-term stability and the highest conversion efficiencies among all thin-film solar cells, reaching 20%. A variety of methods have been reported to prepare CIGS thin film. Efficiency of solar cells depends upon the various deposition methods as they control optoelectronic properties of the layers and interfaces. CIGS thin film grown on glass or flexible (metal foil, polyimide) substrates require p-type absorber layers of optimum optoelectronic properties and n-type wideband gap partner layers to form the p-n junction. Transparent conducting oxide and specific metal layers are used for front and back contacts. Progress made in the field of CIGS solar cell in recent years has been reviewed.
Conselho Superior de Censura - Composição por lei - Representação de classe (1984)

Tribunal Federal de Recursos
Associations Between Indoor CO<sub>2</sub> Concentrations and Sick Building Syndrome Symptoms in U.S. Office Buildings: An Analysis of the 1994-1996 BASE Study Data (2000)

Higher indoor concentrations of air pollutants due, in part, to lower ventilation rates are a potential cause of sick building syndrome (SBS) symptoms in office workers. The indoor carbon dioxide (CO2) concentration is an approximate surrogate for indoor concentrations of other occupant-generated pollutants and for ventilation rate per occupant. Using multivariate logistic regression (MLR) analyses, we evaluated the relationship between indoor CO2 concentrations and SBS symptoms in occupants from a probability sample of 41 U.S. office buildings. Two CO2 metrics were constructed: average workday indoor minus average outdoor CO2 (dCO2, range 6-418 ppm), and maximum indoor 1-h moving average CO2 minus outdoor CO2 concentrations (dCO2MAX). MLR analyses quantified dCO2/SBS symptom associations, adjusting for personal and environmental factors. A dose-response relationship (p < 0.05) with odds ratios per 100 ppm dCO2 ranging from 1.2 to 1.5 for sore throat, nose/sinus, tight chest, and wheezing was observed. The dCO2MAX/SBS regression results were similar.
One Judge for One Family: Differentiated Case Management for Families in Continuing Conflict (2010)

Understanding the differences between family cases and other types of litigation is essential for an appropriate response to family disputes. Judges have a role in family cases that markedly differs from the traditional judicial role. The authors argue that an effective and accessible family justice system requires pre-trial and post-trial case management by a single judge, an approach to family justice reflected in the slogan: "One judge for one family." Judges should have the necessary knowledge, skills, and training needed to resolve family disputes and to help effect changes in parental behaviours and attitudes, as well as the willingness to collaborate effectively with non"legal professionals. A differentiated approach to the way each family case is managed is required, varying with the nature of the case, the nature and level of the conflict, and the stage of the litigation process. The paper includes consideration of Canadian approaches to judicial case management, including analysis of the small body of reported case law on the reasons for judicial managing and monitoring family cases before and after trial, and on recusal—when to stop case management.
Novel peptides as potential treatment of systemic lupus erythematosus (2011)

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a loss of immunologic tolerance, production of auto-antibodies, and inflammatory damage in multiple organs. We have tested the effect of anti-inflammatory peptide, a H2A histone fragment, termed IIIM1, on MRL/lpr mice, animal model of SLE. Oral administration of IIIM1 at early stage of disease caused reduction in proteinuria and serum anti-dsDNA antibodies. Starting the treatment at advanced stage of disease resulted in prolonged animal survival, decreased lymphadenosis and reduced levels of pathogenic or abnormal double negative CD4(-)CD8(-) cells and B220(+) cells in lymph nodes and spleen. We discovered that IIIM1 induces the production of an additional peptide, a fragment of alpha-1-antitrypsin, termed UBE. A relatively low dose (1 µg/kg) of UBE reduced proteinuria and hematuria in MRL/lpr mice. The beneficial effect of the peptide was corroborated by histological examination. Furthermore a significant reduction in serum IL17, IL12 and anti dsDNA antibodies was observed in the UBE-treated mice. Isolated CD4 cells incubated with the peptide showed a similar cytokine profile. Decreased levels of double negative CD4(-)CD8(-) and B220(+) cells were determined in lymph organs of UBE-treated animals. The beneficial effects of both UBE and IIIM1 suggest these peptides as potential drugs for SLE.
Recycling kinetics and transcytosis of transferrin in primary cultures of bovine brain microvessel endothelial cells (1991)

Primary cultures of bovine brain microvessel endothelial cells (BMECs) were used to examine the cycling kinetics of ferrotransferrin (Tf) and to provide evidence for a transcytotic pathway in vitro. Binding of 125I-Tf to BMECs grown on matrix-coated plastic was measured in the presence of saponin to calculate the total number of transferrin receptors (TfRs). Nonlinear regression analysis of the binding isotherm showed that there were 100,000 high-affinity receptors per cell and that expression was maximum at cell confluence. Binding of Tf at 4 degrees C indicated that there was a large intracellular receptor pool comprising 85-90% of the total cellular receptors. Accumulation of Tf at 37 degrees C, inhibited at low temperature and in the presence of metabolic poisons, occurred with an initial rate coefficient of 0.030 min-1 and this decreased by 83% after 60 min. Concomitant accumulation of 59Fe from Tf-59Fe was linear. In the absence of externally added ligand, 80% of the accumulated 125I-Tf was released into the medium with a rate coefficient of 0.017 min-1 and this was inhibited at low temperature. In the presence of the weak base primaquine, the accumulation of Tf and 59Fe and the efflux of Tf were decreased. Moreover, phorbol myristate acetate (PMA) caused a 30% increase in surface TfRs and an 82% increase in Tf accumulation, although the size of the recycling pool remained unchanged. Despite the low numbers of TfR expressed by post-confluent cells, filter-grown BMEC monolayers were used to measure transcytosis of Tf. A small portion of the Tf that was accumulated from the apical side entered a transcytotic pathway. Most of the Tf and all of an accumulated fluid-phase tracer were recycled towards the apical side. These results showed that cultured BMECs cycle Tf-TfR complexes slowly and vectorially and suggested that the large intracellular receptor pool may facilitate steady state accumulation and regulate transcellular transport of iron.
Plant performance and water use of peppermint treated with methanol and glycine (1994)

Abstract Methanol applied to foliage has been reported to reduce water use of C3 crops. Two field experiments on peppermint measured both plant performance and soil water depletion for methanol, glycine, and an untreated control. No differences were found in dry matter yield, oil yield, plant height, leaf weight, or water use. Preliminary phytotoxicity studies showed no toxicity or necrosis at concentrations up to 99 percent methanol applied at a rate of 187 L/ha in the field.
Multi-Group Signature Scheme for Simultaneous Verification by Neighbor Services (2017)

We focus on the construction of the digital signature scheme for local broadcast, which allows the devices with limited resources to securely transmit broadcast message. A multi-group authentication scheme that enables a node to authenticate its membership in multi verifiers by the sum of the secret keys has been proposed for limited resources. This paper presents a transformation which converts a multi-group authentication into a multi-group signature scheme. We show that the multi-group signature scheme converted by our transformation is existentially unforgeable against chosen message attacks (EUF-CMA secure) in the random oracle model if the multi-group authentication scheme is secure against impersonation under passive attacks (IMP-PA secure). In the multi-group signature scheme, a sender can sign a message by the secret keys which multiple certification authorities issue and the signature can validate the authenticity and integrity of the message to multiple verifiers. As a specific configuration example, we show the example in which the multi-group signature scheme by converting an error correcting code-based multi-group authentication scheme.
Quantification of epithelial volume by image processing applied to ovarian tumors (1987)

This paper describes an image analysis technique for automated estimation of the percentages of epithelium and stroma in (tumor) tissue. The program is evaluated on ovarian tumors of the serous, mucinous, and endometrioid type. From standard paraffin sections, stained with pararosanilin Feulgen and naphthol yellow, a blue-yellow image pair was recorded. The blue image was used for the determination of the total tissue area and the yellow image for the epithelial area. For the latter the image processing method is based on the fact that epithelial nuclei are generally more tightly packed than stromal nuclei. A structural approach was applied, in which the segmentation of the nuclei was based on the image contrast range in the density domain. The method has been tested with 78 image pairs from 19 ovarian tumors with varying degrees of malignancy. The area percentages, as assessed with image processing, were strongly correlated to control percentages, established by interactive morphometry (r = 0.98).
Medical Treatment of Alcohol Dependence: A Systematic Review (2011)

Although treatment effects are modest, medications for alcohol dependence, in conjunction with either brief support or more extensive psychosocial therapy, can be effective in primary and specialty care medical settings.
A distributed colouring algorithm for control hazards in asynchronous pipelines (2004)

Synchronous VLSI design is approaching a critical point, with clock distribution becoming an increasingly costly and complicated issue and power consumption rapidly emerging as a major concern. Hence, recently, there has been a resurgence of interest in asynchronous digital design techniques as they promise to liberate VLSI systems from clock skew problems, offer the potential for low power and high performance and encourage a modular design philosophy which makes incremental technological migration a much easier task. In a pipelined architecture, if a control hazard occurs, the prefetched instructions following a hazard must be discarded and removed from the pipeline before instructions from the new stream are executed. In an asynchronous microprocessor the exact number of the prefetched instructions is nondeterministic and unpredictable. The processor must be able to distinguish between instructions originating from the branch or the exception target, which may thus be executed, and instructions already prefetched when the hazard took place, which must therefore be thrown away. This paper discusses a distributed, asynchronous technique for dealing with control hazards in asynchronous pipelines where control hazards may potentially occur in more than one stage.
L1 Adaptive Control for Flexible Space Launch Vehicle and Proposed Plan for Flight Validation (2008)

This paper explores application of the L1 adaptive control architecture to a generic flexible Crew Launch Vehicle (CLV). Adaptive control has the potential to improve performance and enhance safety of space vehicles that often operate in very unforgiving and occasionally highly uncertain environments. NASA s development of the next generation space launch vehicles presents an opportunity for adaptive control to contribute to improved performance of this statically unstable vehicle with low damping and low bending frequency flexible dynamics. In this paper, we consider the L1 adaptive output feedback controller to control the low frequency structural modes and propose steps to validate the adaptive controller performance utilizing one of the experimental test flights for the CLV Ares-I Program.
Age-related production of new granule cells in the adult dentate gyrus (1995)

Unlike most neurones, the dentate granule cells continue to be produced in adults. Recently our study has demonstrated that a highly polysialylated neural cell adhesion molecule (NCAM-H) is a reliable molecular marker for newly generated and developing dentate granule cells. Here we examined age-related changes in the number of newly generated and developing granule cells. In rats injected with 5-bromo-2'-deoxyuridine (BrdU), a thymidine analogue, at 35 days to 18 months of age, double immunohistochemistry for BrdU and NCAM-H showed that the numbers of NCAM-H-positive and BrdU-/NCAM-H-positive granule cells gradually decreased over more than one year, but they were still detected in 18-month-old rats. These findings indicate that newly formed and developing granule cells occur in the dentate gyrus of young and aged rats, but the number of these cells decreases with age.
MARTENSITE IN TITANIUM ALLOYS (1959)

The formation of martensite by deformation and aging at --70 deg C as well as its re-solution and regeneration were studied with the alloy TiV16Al3. The effect of the martensite upon age hardening and the influence of nonstable preparatory modifications of the alpha phase upon martensite formation and mechanical properties were investigated. The dependence of Young's modulus of martensitic titanium--molybdenum alloys on internal stresses and the effect of hydrogen and deformation upon Young's modulus of TiV16Al3 were also studied. The results are discussed. (auth)
Multiple metal-carbon bonds. 13. Preparation and characterization of monocyclopentadienyl mononeopentylidene complexes of niobium and tantalum including the first details of an .alpha.-abstraction process (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 13. Preparation and characterization of monocyclopentadienyl mononeopentylidene complexes of niobium and tantalum including the first details of an .alpha.-abstraction processC. D. Wood, S. J. McLain, and R. R. SchrockCite this: J. Am. Chem. Soc. 1979, 101, 12, 3210–3222Publication Date (Print):June 1, 1979Publication History Published online1 May 2002Published inissue 1 June 1979https://pubs.acs.org/doi/10.1021/ja00506a014https://doi.org/10.1021/ja00506a014research-articleACS PublicationsRequest reuse permissionsArticle Views607Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Management truck tire information in logistic industry using RFID technology (2008)

Logistics plays pivotal role in the supply chain as well as in developing countrypsilas competitive edge. According to Thailand Department of Land Transportation report in 2006, there were 848,843 registered trucks which are key driver of cargo transportation. It is apparent that business sector becomes very competitive, and thus, fleet operators have to minimize their operating cost in order to edge at its competitor. Other thing being equal, two variables affect operating cost. First is fuel expenses, which is world commodity and market fluctuation is inevitable. Truck tires are another contribution to the operating cost. Unlike the fuel, the truck tires can be retreaded and, hence, the operating cost can be reduced. Effective tire management can prolong its life span significantly before renewal. Software, addressing tire pressure, temperature and tire types, would provide tire management solution. In this paper, we present the effectiveness of deploying the RFID system in acquiring information for tire management via testing RFID systems in one tire re-treading company. We analyze the trade off between operating time and system implementation cost. The performance of RFID on the different tire types is also studied. Last but not least, we propose a RFID system configuration to minimize data acquisition time.
Preparation of Pure Silicon by the Hydrogen Reduction of Silicon Tetraiodide (1957)

The reduction of silicon tetraiodide by hydrogen to form pure silicon and hydrogen iodide has been investigated. The reaction is heterogeneous, taking place on a hot surface. Dense silicon layers as well as crystals can be deposited. The reaction gives a chemical yield as high as 96%, but the over‐all best conditions found resulted in a rate of deposition of 4.4 g Si/dm2/hr at a chemical yield of 55%. Data on the purity of the silicon obtained are presented.
An “Electronic Fluorescent Pictograph” Browser for Exploring and Analyzing Large-Scale Biological Data Sets (2007)

The eFP Browser software is easily adaptable to microarray or other large-scale data sets from any organism and thus should prove useful to a wide community for visualizing and interpreting these data sets for hypothesis generation.