gebhart/patrepeval huggingface dataset:
CB1 Agonist ACEA Protects Neurons and Reduces the Cognitive Impairment of AβPP/PS1 Mice (2012)

The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, reduces the cognitive impairment observed in double AβPP(swe)/PS1(1dE9) transgenic mice from 6 months of age onwards. ACEA has no effect on amyloid-β (Aβ) production, aggregation, or clearance. However, ACEA reduces the cytotoxic effect of Aβ42 oligomers in primary cultures of cortical neurons, and reverses Aβ-induced dephosphorylation of glycogen synthase kinase-3β (GSK3β) in vitro and in vivo. Reduced activity of GSK3β in ACEA-treated mice is further supported by the reduced amount of phospho-tau (Thr181) in neuritic processes around Aβ plaques. In addition, ACEA-treated mice show decreased astroglial response in the vicinity of Aβ plaques and decreased expression of the pro-inflammatory cytokine interferon-γ in astrocytes when compared with age-matched vehicle-treated transgenic mice. Our present results show a beneficial effect of ACEA at both the neuronal, mediated at least in part by GSK3β inhibition, and glial levels, resulting in a reduction of reactive astrocytes and lower expression of interferon-γ. As a consequence, targeting the CB1 receptor could offer a versatile approach for the treatment of Alzheimer's disease.
Monolithic tunable active inductor with independent Q control (2000)

A 1.1-GHz fully integrated GaAs MESFET active inductor is presented in this paper. Both the inductance and loss resistance are tunable with the inductance independent of series loss tuning. The measured loss resistance is tunable over a -10- to +15-/spl Omega/ range with a corresponding change in inductance of less than 10% at 100 MHz and less than 4% for frequencies above 500 MHz. The inductance is tunable from 65 to 90 nH. Considerably larger bandwidths can be achieved depending on the fabrication technology employed and the intended application of the circuit.
An immortalized cell line with features of human follicular dendritic cells. Antigen and cytokine expression analysis (1994)

Follicular dendritic cells (FDC) are specialized cells residing primarily within lymphoid follicles. They bind immunocomplexes and play an important role in the presentation of antigen to follicular B cells. Isolation of FDC for in vitro studies, however, is difficult because they constitute only about 1% of the cells in lymphoid tissue and form tight clusters entrapping lymphocytes within their dendritic processes. The monoclonal antibody (mAb) Ki-M4, which is highly restricted in its binding to FDC, is used to identify these cells. In order to establish a new immortalized cell line with features of FDC, we applied a modified procedure to isolate and enrich FDC from human tonsils and fused them with the myeloma cell line SP2/0-Ag14. The new hybrid cell line, designated FDC-H1, is of both mouse lymphoid and human FDC origin. FDC-H1 was found to have unlimited growth potential and to consistently express the Ki-M4 antigen and other surface antigens of human FDC. Semiquantitative reverse-transcribed polymerase chain reaction (RT-PCR) of enriched FDC and FDC-H1 revealed the same highly restricted cytokine/mRNA profile for both, with detectable levels of interleukin (IL)-1 alpha and surface CD23 and a lack of mRNA for IL-1 beta, IL-2, IL-3, IL-4, IL-7, IL-9, IL-10, interferon-gamma, tumor necrosis factor-alpha, transforming growth factor-beta and granulocyte/macrophage-colony-stimulating factor. Additionally a weak but constant IL-6 mRNA expression was found in the cell line FDC-H1 by RT-PCR. In situ hybridization experiments in tonsils revealed IL-6 transcripts in cells with a staining pattern characteristic of a dendritic cell only in a few germinal centers. To our knowledge, FDC-H1 is the first cell line that constantly expresses surface antigens and a cytokine profile characteristic of FDC. It is, therefore, well suited for studying the biology of FDC and the functional relationship between FDC and normal or neoplastic lymphatic cells.
Stereoselectivity in chiral iron(III) and gallium(III) tris(catecholate) complexes effected by nonbonded weakly polar interactions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselectivity in chiral iron(III) and gallium(III) tris(catecholate) complexes effected by nonbonded weakly polar interactionsTimothy B. Karpishin, T. D. P. Stack, and Kenneth N. RaymondCite this: J. Am. Chem. Soc. 1993, 115, 14, 6115–6125Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/ja00067a029https://doi.org/10.1021/ja00067a029research-articleACS PublicationsRequest reuse permissionsArticle Views708Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
A Study of Computer-Assisted Tomography (1984)

In order to study the type and number of CAT scan abnormalities of the lumbar spine that occur in asymptomatic people, 52 studies from a control population with no history of back trouble were mixed randomly with six scans from patients with surgically proven spinal disease, and all were interpreted by three neuroradiologists in a blinded fashion. Irrespective of age, 35.4% (26.6%, 51.0%, and 31.3%) were found to be abnormal. Spinal disease was identified in an average of 19.5% (23.8%, 22.7%, and 12.5%) of the under 40-year-olds, and it was a herniated nucleus pulposus in every instance. In the over 40-year-old age group, there was an average of 50% (29.2%, 81.5%, and 48.1%) abnormal findings, with diagnoses of herniated disc, facet degeneration, and stenosis occurring most frequently.
Dielectric constants of BaO and melilites and the oxide additivity rule (1992)

The constant-stress free dielectric constants and dissipation factors of BaO and a series of X_2YZ_2O_7
melilites were measured at 1 MHz using a two-terminal method and empirically determined edge corrections. The
results are: 
BaO K = 31.1
Ca_2MgSi_2O_7 K^T_a = 11.83 K^T_c = 7.97
Ca_2CoSi_2O_7 K^T_a = 12.44 K^T_c = 9.00
Ca_2ZnSi_2O_7 K^T_a = 12.03 K^T_c = 8.21
Sr_2CoSi_2O_7 K^T_a = 8.93 K^T_c = 6.87
Ba_2MgGe_2O_7:Nd,Ce = K^T_a = K^T_c= 7.51.

The discrepancies between measured dielectric polarizabilities as determined from the Clausius-Mosotti equation and those calculated from the sum of oxide polarizabilities according to ɑ_D(X_2YZ_2O_7) = 2 ɑ_D(XO) + ɑ_D(YO) + 2 α_D(Z0_2) are + 13.6 to + 16.0% for Ca-containing melilites, + 6.1% for Sr_2CoSi_2O_7 and + 1.0% for Ba_(1.92)Nd_(0.04)Ce_(0.04)MgGe_2O_7. The deviations from additivity in the Ca- and Sr-melilites are believed to result from structural misfit between the alkaline earth X ion and the YZ_2O_7 layers which leads to rattling X ions.
Modulated precursor flow epitaxial growth of AlN layers on native AlN substrates by metal-organic chemical vapor deposition (2008)

We have investigated the growth of AlN layers on bulk AlN substrates by modulated precursor flow epitaxial growth using metal-organic and hydride precursors as well as by conventional metal-organic chemical vapor deposition growth. A nanopit-containing morphology was observed for an AlN layer grown by conventional growth, while atomically smooth and pit-free surface was achieved for an AlN layer created by modulated precursor flow epitaxial growth. For similar growth set-point temperatures, nanopit-free surfaces were observed for AlN layers created by conventional growth on sapphire substrates. This is believed to be due to the difference in the temperature of the growing surface, as evidenced by finite element method thermal profiling and the morphology change of the AlN layer with decreasing temperature observed for growth of AlN on sapphire substrates. The AlN layers grown by modulated precursor flow epitaxial growth on the AlN bulk substrates also have excellent crystalline qualities with narrow x-ray rocking curve peak linewidths of 36 and 61arcsec for the (002) and (102) diffraction conditions, respectively.
Selective Blockade of Endothelin-B Receptors Exacerbates Ischemic Brain Damage in the Rat (2002)

Our results suggest that the ET(B) antagonist BQ-788 induces deleterious effects that are mediated by the reduction of residual blood flow after ischemia and argue that the optimal therapeutic strategy in stroke would be to target the use of selective ET(A) antagonists and not mixed ET(A)/ET(B) antagonists.
A high throughout assay for human papillomavirus genotypes with fluorescence polarization. (2003)

The proposed method allowed a high throughout, special, simple, rapid, automatic and economical detection of HPV-DNA genotyping without a use of labeling probes. It can detect multiple HPV genotype infection and will be and useful tool in HPV genotype screening.
Anti-angiogenic Activity of the Recombinant Kringle Domain of Urokinase and Its Specific Entry into Endothelial Cells (2003)

Urokinase plasminogen activator (uPA) belongs to a family of proteins that contains kringle domain and plays an important role in inflammation, tissue remodeling, angiogenesis, and tumor metastasis by pericellular plasminogen activation. Kringle domains of plasminogen have been shown to demonstrate anti-angiogenic and anti-tumor activities. Here, we report our investigation of the kringle domain of uPA for anti-angiogenic activity and a possible cellular mechanism of action. The recombinant kringle domain of uPA (Asp(45)-Lys(135)) (UK1) inhibited endothelial cell proliferation stimulated by basic fibroblast growth factor, vascular endothelial growth factor (VEGF), or epidermal growth factor. It also inhibited migration of endothelial cells induced by VEGF or uPA, and in vivo angiogenesis on the chick chorioallantoic membrane. It did not block plasminogen activation by activated uPA in clot lysis and chromogenic substrate assays. Neither binding of UK1 to immobilized uPA receptor nor competitive inhibition of uPA binding were confirmed by real-time interaction analysis. However, internalization of UK1 followed by translocation from cytosol to nucleus was determined to be specific to endothelial cells. It also elicited a transient increase of Ca(2+) flux of more than 2-fold within 2 min of exposure in an endothelial cell-specific manner. These results suggest that the kringle domain of uPA exhibits anti-angiogenic activity and that its anti-angiogenic activity may occur through a different mechanism from inhibition of uPA-uPA receptor interaction or uPA proteolytic activity and may be associated with endothelial-cell specific internalization not mediated by the uPA receptor.
Experimental Demonstration of Shaken-Lattice Interferometry (2018)

We experimentally demonstrate a shaken-lattice interferometer. Atoms are trapped in the ground Bloch state of a red-detuned optical lattice. Using a closed-loop optimization protocol based on the dcrab algorithm, we phase-modulate (shake) the lattice to transform the atom momentum state. In this way, we implement an atom beam splitter and build five interferometers of varying interrogation times T_{I}. The sensitivity of shaken-lattice interferometry is shown to scale as T_{I}^{2}, consistent with simulation (2C. A. Weidner, H. Yu, R. Kosloff, and D. Z. Anderson, Phys. Rev. A 95, 043624 (2017).PLRAAN2469-992610.1103/PhysRevA.95.043624). Finally, we show that we can measure the sign of an applied signal and optimize the interferometer in the presence of a bias signal.
From Field and Study (1931)

Caught in Spiders' Webs.-Responding to the hurry call of one of my children about 7 a. m. on April 22, 1931, I found a live Coast Bush-tit (Psaltripwus minimus minimus) securely enmeshed in a spider% web close under the eaves of my two-story home ' in San Diego. Feebly struggling in the taut strands of the net, and silhouetted against the sky with one wing extended, the little bird's size, in this unusual situation, seemed magnified when viewed from a near-by window.
The synthesis and characterization of new polymerizable pyrimidines: Immobilization of the monomers onto hydrophilic graft copolymeric supports through radiation-induced copolymerization-grafting (1998)

Polymerizable quaternary allyl-pyrimidinium salts, that is, 1-allyl-4- amino-5-phenyl-pyrimidine (IV), 1-allyl-4-acetamido-5-phenyl-pyrimidine (V), 1-allyl-5-hydroxymethylamino-5-phenyl-pyrimidine (VI), and 1-allyl-pyrimidine (VIII) bromides, as well as 4-acrylamido-5-phenyl-pyrimidines II` and IV`, were synthesized and characterized. Three of the activated pyrimidine derivatives, the two acrylamido and one allyl pyrimidine, were immobilized onto (Agar-g-co-HEMA)-X-TMPTA via graft copolymerization. Each copolymer system, based on 2-hydroxyethyl methacrylate (HEMA) grafted onto Agar followed by crosslinking with trimethyllopropane triacrylate (TMPTA), was prepared by radiation-induced copolymerization carried out in the simultaneous mode. The release properties of the immobilized pyrimidines were assessed in various aqueous media over a period of approximately 22 days. © 1998 John Wiley & Sons, Inc. J. Appl. Polym. Sci. 70: 211–218, 1998
Studies of nerve-muscle interactions in Xenopus cell culture: analysis of early synaptic currents (1989)

We have studied the spontaneous and nerve-evoked synaptic currents during the initial period of nerve-muscle contact in Xenopus cell cultures. The precise timing of the contact was achieved by physically manipulating embryonic muscle cells into contact with co-cultured spinal neurons. Previous studies have shown that physical contact of the muscle membrane induces pulsatile release of acetylcholine (ACh) from the growth cone of these neurons, resulting in spontaneous synaptic currents (SSCs) in the muscle cell within seconds following the contact. In the present work, we first showed that these SSCs at the manipulated nerve-muscle contacts are similar to those observed at naturally occurring synapses. We then examined the possible cellular mechanisms responsible for the marked variation in SSC amplitude and showed that it most likely results from differences in either the amount of ACh contained in each release event or the extent of close membrane apposition near the release sites. During the first 20 min following the nerve-muscle contact, there was an increase in the frequency and mean amplitude of the SSCs. During a similar period, the evoked synaptic currents (ESCs), which were induced by suprathreshold electrical stimulation of the neuronal soma, also showed an increase in the mean amplitude and a reduction in the delay of onset following the stimulus. These postcontact changes in the efficacy of synaptic transmission may be related to an increase in the total area of close membrane apposition between the nerve and muscle cells. This was suggested by the finding that neurite-muscle adhesion increases over a similar postcontact period. The transition from low- to high-efficacy transmission during the early phase of contact may reflect the process of selective adhesion between the cells, and thus signify the formation of specific synapse. Analysis of the fluctuation in the ESC amplitude at the early nerve-muscle contact suggests that evoked release of ACh occurs as multiples of a quantal unit. However, this unit is apparently related to only a small subpopulation of SSCs of relatively high amplitudes.(ABSTRACT TRUNCATED AT 400 WORDS)
A system for retrieving images by content (1994)

Image Retrieval problem is concerned with retrieving images that are relevant to users' requests from a large collection of images, referred to as the image database. A software system that facilitates image retrieval is referred to as the Image Retrieval System. Though conventional database management systems are not suitable for efficiently storing and flexibly retrieving images, by far, the most popular approach has been to use them for realizing image retrieval systems.

In this paper, we provide an overview of earlier approaches to image retrieval systems and describe their limitations. We then briefly describe a novel framework for image retrieval that has been proposed in [1]. Based on this framework, we have developed an image retrieval system that can be easily adapted to the retrieval needs of a class of image retrieval applications. The versatility and the effectiveness of this system is demonstrated by configuring it two image retrieval applications. The first application is a Realtors Information System designed for Real Estate marketing. The intended users of this system are Realtors. The second application is a Face Information Retrieval System designed for use in law enforcement and criminal investigation.
Applied Chemistry at Protein Interfaces (1975)

Some of the areas where interfacial protein layers dominate the boundary chemistry are reviewed, and we introduce some nondestructive analytical methods which can be used simultaneously and/or sequentially to detect and characterize the microscopic amounts of matter at protein or other substrates which spontaneously acquire protein conditioning films. Examples include collagen and gelatin, synthetic polypeptides, nylons, and the biomedically important surfaces of vessel grafts, skin, tissue, and blood. The importance of prerequisite adsorbed films of proteins during thrombus formation, cell adhesion, use of intrauterine contraceptives, development of dental adhesives, and prevention of maritime fouling is discussed. Specifics of protein adsorption at solid/liquid and gas/liquid interfaces are compared.
Anonymity and Transferability for an Electronic Bank Check Scheme (2012)

The advances in electronic commerce are replacing many of the paper processes involved in commercial transactions, from the contracting process to the electronic payment process. When we are dealing with payments of high value, bank transfers are preferred. But this kind of payments does not allow the anonymity of the parties involved in the commercial transaction. Electronic checks is a useful payment system for this kind of scenario, but the proposed solutions do not allow an anonymous transference as in paper-based checks. In this paper, we propose a new electronic bearer bank check scheme. The system allows the e-check to be transferred to any person by its owner without depositing it, and remaining anonymous in front of the bank.
Estimation of Software Code Size Based on Quantitative Aspects of Function (With Application of Expert System Technology) (1984)

(1984). Estimation of Software Code Size Based on Quantitative Aspects of Function (With Application of Expert System Technology) Journal of Parametrics: Vol. 4, No. 3, pp. 23-34.
Enhancement Of Commercially-available Thermal Grease By Multi-walled Carbon nanotubes For Electronic Device Applications  (2013)

Thermal grease is generally used as a thermal interface material for improved conduction between a heat source and heat sink. Here, we report the enhancement of thermal conductivity of commercially available off-the-shelf thermal grease (thermal compound LS6006) used in cooling of electronic devices, by the addition of multiwalled carbon nanotubes (MWCNTs). The thermal conductivity of the MWCNT mats and MWCNT modified thermal grease was measured relative to the thermal conductivity of the grease, which was taken as the benchmark. The thermal conductivity improves and the optimum thermal management is observed for aligned MWCNT arrays glued through the thermal grease.
Multichannel ECG Analysis Using VPW-FRI (2013)

In this paper, we present an application of Variable Pulse Width Finite Rate of Innovation (VPW-FRI) in dealing with multichannel Electrocardiogram (ECG) data using a common annihilator. By extending the conventional FRI model to include additional parameters such as pulse width and asymmetry, VPWFRI has been able to deal with a more general class of pulses. The common annihilator, which is introduced in the annihilating filter step, shows a common support in multichannel ECG data, which provides interesting possibilities in compression. A model based de-noising method will be presented which is fast and noniterative. Also, an application to detect QRS complexes in ECG signals will be demonstrated. The results will show the robustness of the common annihilator and the QRS detection even in the presence of noise.
Developmental Responses of Resistance to Magnaporthe grisea and Xanthomonas campestris pv. oryzae in Lesion-mimic Mutants of Rice (2003)

We characterized five lesion-mimic mutants of rice (Oryza sativa L.), spotted leaf 5-2 (spl5-2), Spl12, spl13, spl14 and Spl15, all of which have broad-spectrum resistance to the rice blast fungus Magnaporthe grisea and the bacterial blight pathogen Xanthomonas campestris pv. oryzae. First, we analyzed the influence of gene dosage on disease resistance and lesion-mimicry. Although the frequency of lesion-mimicry was lower in heterozygous Spl12 plants than in homozygous plants, the heterozygotes had almost the same levels of resistance to rice blast and bacterial blight as the homozygotes. Second, we analyzed whether developmental regulation of disease resistance differed in dominant and recessive mutants. We inoculated leaves at different leaf positions at the heading stage with bacterial blight, and found that spl5-2 and Spl12 mutants displayed enhanced resistance in lower and upper leaves but the level of resistance was higher in the upper leaves. Furthermore, we clarified the disease resistance and lesion-mimicry by inoculating the top expanded leaves at various developmental stages with bacterial blight. The dominant mutants (Spl12 and Spl15) showed lesion-mimicry from an earlier stage than did the recessive mutants (spl5-2, spl13 and spl14); the lesion-mimicry was more severe, and their resistance was rather greater, than in the recessive mutants. Finally, we studied the phenotypes of the progeny of crosses between the spl mutants. Although the lesion-mimicry of the Spl12 spl14 double mutant was additive, the resistance phenotype of the double mutant equaled that of spl14. These results demonstrate that the mechanism by which SPL genes activate cell death and defense differs among dominant and recessive mutants.
FUZZY FILTERS ON THE RESIDUATED LATTICES (2006)

In this paper, the lattice operations and the adjoint pair on the fuzzy filters set on residuated lattices are defined, the conclusion that the fuzzy filters lattice defined as such is a distributive residuated lattice is obtained. An order-reversing involution on the fuzzy strong-prime filters sublattice is introduced. It is proved that the fuzzy strong-prime filters sublattice is a quasi-Boolean algebra.
Studies on positive inotropic agents. V. Synthesis of 1-heteroaroylpiperazine derivatives. (1988)

A series of 1-heteroaroylpiperazines (V-VII, XI) was synthesized and examined for positive inotropic activities on the canine heart. The key intermediates, heteroarenecarboxylic acids (III, X), were prepared by two different methods, and were condensed with substituted piperazines to give 1-heteroaroylpiperazines V-VII and XI. Among them, quinazoline derivatives (XI) were found to have potent positive inotropic activities.