gebhart/patrepeval huggingface dataset:
Habituation and Prepulse Inhibition of Acoustic Startle in Rodents (2011)

The acoustic startle response is a protective response, elicited by a sudden and intense acoustic stimulus. Facial and skeletal muscles are activated within a few milliseconds, leading to a whole body flinch in rodents(1). Although startle responses are reflexive responses that can be reliably elicited, they are not stereotypic. They can be modulated by emotions such as fear (fear potentiated startle) and joy (joy attenuated startle), by non-associative learning processes such as habituation and sensitization, and by other sensory stimuli through sensory gating processes (prepulse inhibition), turning startle responses into an excellent tool for assessing emotions, learning, and sensory gating, for review see( 2, 3). The primary pathway mediating startle responses is very short and well described, qualifying startle also as an excellent model for studying the underlying mechanisms for behavioural plasticity on a cellular/molecular level(3). We here describe a method for assessing short-term habituation, long-term habituation and prepulse inhibition of acoustic startle responses in rodents. Habituation describes the decrease of the startle response magnitude upon repeated presentation of the same stimulus. Habituation within a testing session is called short-term habituation (STH) and is reversible upon a period of several minutes without stimulation. Habituation between testing sessions is called long-term habituation (LTH)(4). Habituation is stimulus specific(5). Prepulse inhibition is the attenuation of a startle response by a preceding non-startling sensory stimulus(6). The interval between prepulse and startle stimulus can vary from 6 to up to 2000 ms. The prepulse can be any modality, however, acoustic prepulses are the most commonly used. Habituation is a form of non-associative learning. It can also be viewed as a form of sensory filtering, since it reduces the organisms' response to a non-threatening stimulus. Prepulse inhibition (PPI) was originally developed in human neuropsychiatric research as an operational measure for sensory gating(7). PPI deficits may represent the interface of "psychosis and cognition" as they seem to predict cognitive impairment(8-10). Both habituation and PPI are disrupted in patients suffering from schizophrenia(11), and PPI disruptions have shown to be, at least in some cases, amenable to treatment with mostly atypical antipsychotics(12, 13). However, other mental and neurodegenerative diseases are also accompanied by disruption in habituation and/or PPI, such as autism spectrum disorders (slower habituation), obsessive compulsive disorder, Tourette's syndrome, Huntington's disease, Parkinson's disease, and Alzheimer's Disease (PPI)(11, 14, 15) Dopamine induced PPI deficits are a commonly used animal model for the screening of antipsychotic drugs(16), but PPI deficits can also be induced by many other psychomimetic drugs, environmental modifications and surgical procedures.
Polκ protects mammalian cells against the lethal and mutagenic effects of benzo[ <i>a</i> ]pyrene (2002)

Several low-fidelity DNA polymerases have recently been discovered that are able to bypass DNA lesions during DNA synthesis in vitro. The efficiency and accuracy of lesion bypass is, however, both polymerase and lesion specific. For example, in vitro studies revealed that human DNA polymerase kappa (Polkappa) is unable to insert a base opposite a cis-syn thymine-thymine dimer or cisplatin adduct, yet can bypass some DNA lesions such as abasic site and acetylaminofluorene-adducted guanine in an error-prone manner. More importantly, Polkappa is able to bypass benzo[a]pyrene (B[a]P)-adducted guanine accurately and efficiently. To investigate the biological function of Polkappa, we have generated mouse embryonic stem (ES) cells deficient in the Polk gene encoding the enzyme. Polk-deficient ES cells grow normally and their sensitivities to UV and x-ray radiation are only slightly affected. In contrast, the mutant cells are highly sensitive to both killing and mutagenesis induced by B[a]P. Furthermore, the spectrum of mutations recovered in the Polk-deficient cells is different from that in the wild-type cells. Thus, our results indicate that Polkappa plays an important role in suppressing mutations at DNA lesions generated by B[a]P.
Efficient Deployment of Multiple Unmanned Aerial Vehicles for Optimal Wireless Coverage (2016)

In this letter, the efficient deployment of multiple unmanned aerial vehicles (UAVs) acting as wireless base stations that provide coverage for ground users is analyzed. First, the downlink coverage probability for UAVs as a function of the altitude and the antenna gain is derived. Next, using circle packing theory, the 3-D locations of the UAVs is determined in a way that the total coverage area is maximized while maximizing the coverage lifetime of the UAVs. Our results show that, in order to mitigate interference, the altitude of the UAVs must be properly adjusted based on the beamwidth of the directional antenna as well as coverage requirements. Furthermore, the minimum number of UAVs needed to guarantee a target coverage probability for a given geographical area is determined. Numerical results evaluate various tradeoffs.
Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine (Eur. J. Org. Chem. 21/2013) (2013)

The cover picture shows the structures of several 7-deazaguanosine (Q, galQ, preQ1, preQ0, gluQ, oQ) and the X-ray structure of tRNAAsp.The tRNA data was obtained from the pbd file of the strcuture published by Briand et al. (J. Mol. Biol. 2000, 299, 1051) containing the hypermodified nucleoside queuosine (Q) in the wobble position (position 34) and the image was created in PyMOL. Prokaryotes can synthesize Q de novo via epoxyqueuosine (oQ) as the direct biosynthesis precursor. The total synthesis of oQ discussed in the Short Communication by I. Thoma and T. Carell on page 4483 ff.. The cover picture shows the structures of several 7-deazaguanosine (Q, galQ, preQ1, preQ0, gluQ, oQ) and the X-ray structure of tRNAAsp.The tRNA data was obtained from the pbd file of the strcuture published by Briand et al. (J. Mol. Biol. 2000, 299, 1051) containing the hypermodified nucleoside queuosine (Q) in the wobble position (position 34) and the image was created in PyMOL. Prokaryotes can synthesize Q de novo via epoxyqueuosine (oQ) as the direct biosynthesis precursor. The total synthesis of oQ discussed in the Short Communication by I. Thoma and T. Carell on page 4483 ff..
Cloning, Expression, and Functional Characterization of the Substrate Binding Subunit of Rat Type II Iodothyronine 5′-Deiodinase (2000)

Type II iodothyronine 5'-deiodinase catalyzes the bioactivation of thyroid hormone in the brain. In astrocytes, this approximately 200-kDa, membrane-bound enzyme is composed of at least one p29 subunit, an approximately 60-kDa, cAMP-induced activation protein, and one or more unidentified catalytic subunit(s). Recently, an artificial type II-like selenodeiodinase was engineered by fusing two independent cDNAs together; however, no native type II selenodeiodinase polypeptide is translated in the brain or brown adipose tissue of rats. These data suggest that the native type II 5'-deiodinase in rat brain is unrelated to this artificial selenoprotein. In this report, we describe the cloning of the 29-kDa subunit (p29) of type II 5'-deiodinase from a lambdazapII cDNA library prepared from cAMP-induced astrocytes. The 3.3-kilobase (kb) cDNA encodes an approximately 30-kDa, 277-amino acid long, hydrophobic protein lacking selenocysteine. Northern blot analysis showed that a 3.5-kb p29 mRNA was present in tissues showing type II 5'-deiodinase activity such as brain and cAMP-stimulated astrocytes. Domain-specific, anti-p29 antibodies specifically immunoprecipitated enzyme activity. Overexpression of exogenous p29 or a green fluorescence protein (GFP)-tagged p29 fusion protein led to a >100-fold increase in deiodinating activity in cAMP-stimulated astrocytes, and the increased activity was specifically immunoprecipitated by anti-GFP antibodies. Steady-state reaction kinetics of the enzyme in GFP-tagged p29-expressing astrocytes are identical to those of the native enzyme in brain. Direct injection of replication-deficient Ad5-p29(GFP) virus particles into the cerebral cortex of neonatal rats leads to a approximately 2-fold increase in brain type II 5'-deiodinating activity. These data show 1) that the 3.3-kb p29 cDNA encodes an essential subunit of rat type II iodothyronine 5'-deiodinase and 2) identify the first non-selenocysteine containing subunit of the deiodinase family of enzymes.
Performance of small animal PET instrument with 1 mm resolution (2003)

A single-plane PET imaging instrument using LSO detectors has been constructed to demonstrate the feasibility of imaging at 1 mm spatial resolution. The performance of this instrument has been evaluated in phantoms and small animals. Measurements presented include spatial resolution, sensitivity, count-rate performance, linearity and field uniformity. Examples of several mouse imaging studies are also presented.
A Pentameric Luminescent-Conjugated Oligothiophene for Optical Imaging of In Vitro-Formed Amyloid Fibrils and Protein Aggregates in Tissue Sections (2012)

Luminescent-conjugated oligo- and polythiophenes (LCOs and LCPs) are valuable tools for optical imaging of a plethora of protein aggregates associated with amyloidoses. Here, we describe the utilization of an anionic pentameric LCO, p-FTAA, for staining of protein aggregates in a variety of platforms, including in vitro-formed amyloid fibrils and tissue sections.
Point mutation detection technology for the new-century laboratory. (2001)

The READIT system represents the newest contribution to point mutation detection technology. Specifically, the system involves hybridizing DNA or RNA probes using phosphorylation chemistry and luciferase as the detection method. The two primary features that distinguish the READIT technology from the competition are its versatility and the ability of users to design its own probes. The automated genotype assignment and statistical analysis simplify the use of this system even more. In the year 2002 more than a million tests will be performed in molecular diagnostics with significant contributions from both research and private laboratories.(1) The most important attributes for laboratorians when reviewing a new technology are cost, accuracy, automation, and ease of use. The advent of unique point mutation detection technologies will certainly assist the role of the laboratory in demonstrating the positive impact of testing on future applications of these technologies. Cost savings, accuracy, simplicity, and flexible throughput are the must-have features of successful point mutation detection technologies for the new-century laboratory.
An Optimal Algorithm for Euclidean Shortest Paths in the Plane (1999)

We propose an optimal-time algorithm for a classical problem in plane computational geometry: computing a shortest path between two points in the presence of polygonal obstacles. Our algorithm runs in worst-case time O(n log n) and requires O(n log n) space, where n is the total number of vertices in the obstacle polygons. The algorithm is based on an efficient implementation of wavefront propagation among polygonal obstacles, and it actually computes a planar map encoding shortest paths from a fixed source point to all other points of the plane; the map can be used to answer single-source shortest path queries in O(log n) time. The time complexity of our algorithm is a significant improvement over all previously published results on the shortest path problem. Finally, we also discuss extensions to more general shortest path problems, involving nonpoint and multiple sources.
I/Q mismatch compensation in a 90nm low-IF CMOS receiver (2005)

An I/Q mismatch compensation circuit for a low-IF GSM receiver implemented in a 90nm CMOS process is presented. A single-tap adaptive decorrelation technique is used with L/sub 1/-norm inverse power measurement and gear-shifting circuits. An image rejection ratio in excess of 50dB is achieved allowing the receiver to use IF frequencies higher than half of the channel bandwidth.
Resolution of Racemic Amino Acids by Gas Chromatography on Optically Active Stationary Phases (1971)

Amino acid enantiomers can be resolved by GC on optically active stationary phases such as N-TFA-L-valyl-L-valine cyclohexyl ester and N-TFA-L-phenylalanyl-L-leucine cyclohexyl ester. TFA-amino acid isopropyl esters have been thus far the most suitable derivatives for this purpose, allowing resolution of higher volatile amino acids. PFP amino acid isopropyl esters have retention times which are up to 47% shorter and give separation of the lower volatile amino acids without a significant loss in the resolution factors. Due to this fact it is now possible to resolve seventeen pairs of the common protein amino acids.
FAS/FAS Ligand Ratio: A Marker of Oxaliplatin-Based Intrinsic and Acquired Resistance in Advanced Colorectal Cancer (2005)

These data strongly indicate that an increment of soluble FAS/soluble FASL ratio after treatment could be an excellent marker of chemosensitivity in colorectal cancer. On the other hand, a decreased ratio after treatment can be a predictor of chemoresistance despite an initial response.
Iron-catalyzed allylic amination (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron-catalyzed allylic aminationMogens Johannsen and Karl Anker JoergensenCite this: J. Org. Chem. 1994, 59, 1, 214–216Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/jo00080a034https://doi.org/10.1021/jo00080a034research-articleACS PublicationsRequest reuse permissionsArticle Views991Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Comparison of the Gastrointestinal Absorption and Bioavailability of Fenofibrate and Fenofibric Acid in Humans (2010)

This study compared the gastrointestinal (GI) absorption characteristics and absolute bioavailability of fenofibric acid and fenofibrate (which is converted to fenofibric acid in vivo) in healthy volunteers. Treatments were delivered to the proximal small bowel, distal small bowel, and colon using a site-specific delivery system (Enterion capsule) and to the stomach by oral administration of equimolar doses. Serial blood samples were collected for 120 hours postdose and assayed for plasma fenofibric acid concentrations. The absolute bioavailability of each treatment was determined relative to 50 mg of fenofibric acid administered intravenously. Plasma exposure to fenofibric acid following fenofibric acid administration was approximately 1.5 times higher than that following fenofibrate administration for delivery to the proximal and distal small bowel and following oral administration, and it was approximately 5 times higher following colon delivery. The absolute bioavailability in the stomach, proximal small bowel, distal small bowel, and colon was approximately 81%, 88%, 84%, and 78%, respectively, for fenofibric acid and 69%, 73%, 66%, and 22%, respectively, for fenofibrate (P < .0001 and P = .033 for fenofibric acid vs fenofibrate in the colon and distal small bowel, respectively). In conclusion, fenofibric acid is well absorbed throughout the GI tract and has greater bioavailability than fenofibrate in all GI regions.
1149.1 scan control transport levels (2002)

1149.1 scan constitutes the most general standard of electronic hardware test control available today. Delivery of an 1149.1 scan service from maintenance processors to system components constitutes a universal challenge to systems designers, and a major opportunity for venders in the chip and scan software business. A largely neglected level of scan transport may rapidly become important to system designers. Offerings in the scan distribution arena can be separated into a number of classes, which can be seen to have a certain hierarchy. In the middle of all of these services is a scan control chip. It is driven by a microprocessor and emits a serial scan string. The author describes the four levels of transport.
Inhibition of metastasis of lewis lung carcinoma by urinary trypsin inhibitor in experimental and spontaneous metastasis models (1995)

A purified human urinary trypsin inhibitor (UTI) and its related synthetic peptides were examined to determine whether they could inhibit production of experimental and spontaneous lung metastases by murine Lewis lung carcinoma (3LL) cells. Three peptides, peptide I, peptide 2 and peptide 3, representing the amino acid sequences within the UTI molecule, were synthesized. UTI and peptide 2 inhibited human leukocyte elastase (HLE). UTI and peptide 3 specifically inhibited human and murine plasmin activity. Peptide I had essentially no inhibitory activity. In an in vivo spontaneous metastasis model, multiple s.c. injections of UTI or peptide 3 for 7 days immediately after s.c. tumor cell inoculation significantly inhibited the formation of lung metastasis in C57BL/6 mice in a dose-dependent manner. UTI reduced lung tumor colonization more effectively than peptide 3. Peptides 1 and 2, however, did not affect the formation of lung metastasis. Inhibition of lung metastasis was not due to direct anti-tumor effects of UTI and peptide 3. In an in vivo experimental metastasis assay, multiple s.c. injections of UTI for 7 days after i.v. tumor cell inoculation inhibited metastatic lung tumor colonization, while peptide 3 did not affect metastasis. Peptides 1 and 2 did not affect the formation of lung metastasis. When examined with an in vitro assay system using a modified Boyden chamber, UTI and peptide 3 suppressed the invasion of tumor cells through Matrigel. UTI and peptide 3 inhibited neither cell proliferation nor the binding of tumor cells to Matrigel and showed no significant suppression of chemotactic migration of tumor cells to fibronectin. Our results suggest that UTI efficiently regulates the mechanism involved in not only the entry into vascular circulation of tumor cells (intravasation, though, at least in part, inhibition of the proteolytic enzyme plasmin) but also the extravasation step of the metastatic process.
A unified and efficient framework for court-net sports video analysis using 3D camera modeling (2007)

The extensive amount of video data stored on available media (hard and optical disks) necessitates video content analysis, which is a cornerstone for different user-friendly applications, such as, smart video retrieval and intelligent video summarization. This paper aims at finding a <i>unified</i> and <i>efficient</i> framework for court-net sports video analysis. We concentrate on techniques that are generally applicable for more than one sports type to come to a unified approach. To this end, our framework employs the concept of multi-level analysis, where a novel 3-D camera modeling is utilized to bridge the gap between the object-level and the scene-level analysis. The new 3-D camera modeling is based on collecting features points from two planes, which are perpendicular to each other, so that a true 3-D reference is obtained. Another important contribution is a new tracking algorithm for the objects (i.e. players). The algorithm can track up to four players simultaneously. The complete system contributes to summarization by various forms of information, of which the most important are the moving trajectory and real-speed of each player, as well as 3-D height information of objects and the semantic event segments in a game. We illustrate the performance of the proposed system by evaluating it for a variety of court-net sports videos containing badminton, tennis and volleyball, and we show that the feature detection performance is above 92% and events detection about 90%.
Glycerol-based mud system resolves hole sloughing problems (1989)

After being tormented by sloughing shales, drilling in Mississippi improved with lower mud cost, longer bit life, less cement consumption, fewer hole troubles and higher drilling speed. The drilling techniques and the glycerol-based mud system made the difference and are discussed in this work.
Ligation of B and T Lymphocyte Attenuator Prevents the Genesis of Experimental Cerebral Malaria (2007)

B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory receptor that is predominantly expressed on T and B cells and dampens T cell activation. In this study, we analyzed the function of BTLA during infection with Plasmodium berghei ANKA. Infection of C57BL/6 mice with this strain leads to sequestration of leukocytes in brain capillaries that is associated with a pathology resembling cerebral malaria in humans. During the course of infection, we found an induction of BTLA in several organs, which was either due to up-regulation of BTLA expression on T cells in the spleen or due to infiltration of BTLA-expressing T cells into the brain. In the brain, we observed a marked induction of BTLA and its ligand herpesvirus entry mediator during cerebral malaria, which was accompanied by an accumulation of predominantly CD8+ T cells, but also CD4+ T cells. Application of an agonistic anti-BTLA mAb caused a significantly reduced incidence of cerebral malaria compared with control mice. Treatment with this Ab also led to a decreased number of T cells that were sequestered in the brain of P. berghei ANKA-infected mice. Our findings indicate that BTLA-herpesvirus entry mediator interactions are functionally involved in T cell regulation during P. berghei ANKA infection of mice and that BTLA is a potential target for therapeutic interventions in severe malaria.
Optimal Driving Efficiency Design for the Single-Phase Brushless DC Fan Motor (2009)

One of the methods to improve efficiency and torque performance of the single-phase brushless DC (BLDC) motor is to find out the optimum commutation angle at each different speed. We used the finite-element method (FEM) to simulate the back-EMF voltage and the coil current for the single-phase BLDC motor, and then adjust the conduction time of switches by detecting the waveform of coil current. The motor can improve its efficiency, noise, and vibration when it obtains the optimal shift angle of each speed. We used PSPICE to verify the exactness of FEM simulation results of the single-phase BLDC motor. We adopted Microchip's dsPIC30F4011 digital signal processor (DSP) to process the Hall signal and the driving signals of switches of the driving system prototype of the single-phase BLDC fan motor. Finally, we used the related experimental results to confirm the feasibility and effectiveness of the proposed driver.