gebhart/patrepeval huggingface dataset:
Silicon-functional 1,2,5-oxadisilacyclopentane heterocyclics (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilicon-functional 1,2,5-oxadisilacyclopentane heterocyclicsCecil L. Frye and Ward T. CollinsCite this: J. Org. Chem. 1970, 35, 9, 2964–2966Publication Date (Print):September 1, 1970Publication History Published online1 May 2002Published inissue 1 September 1970https://pubs.acs.org/doi/10.1021/jo00834a024https://doi.org/10.1021/jo00834a024research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Automating production of run-time reconfigurable designs (2002)

This paper describes a method that automates a key step in producing run-time reconfigurable designs: the identification and mapping of reconfigurable regions. In this method, two successive circuit configurations are matched to locate the components common to them, so that reconfiguration time can be minimized. The circuit configurations are represented as a weighted bipartite graph, to which an efficient matching algorithm is applied. Our method, which supports hierarchical and library-based design, is device-independent and has been tested using Xilinx 6200 FPGAs. A number of examples in arithmetic, pattern matching and image processing are selected to illustrate our approach.
Dynamic Long-Term Anticipation of Chaotic States (2001)

Introducing a short time delay into the coupling of two synchronizing chaotic systems, it was shown recently that the driven system may anticipate the driving system in real time. Augmenting the phase space of the driven system, we accomplish anticipation times that are multiples of the coupling delay time and exceed characteristic time scales of the chaotic dynamics. The stability properties of the associated anticipatory synchronization manifold in certain cases turn out to be the same as for identically synchronizing oscillators.
Direct quantitative determination of peptides and proteins in PVDF transfer membrane using a computing densitometer. (1993)

In this paper we describe a method that makes it possible to quantify bands or spots directly on membranes using a computing densitometer. The method is based on the fact that polyvinylidene difluoride (PVDF) membrane is translucent when immersed in solutions containing > 50% methanol. Peptide markers (2.512-16.949 kDa), as well as purified Neuropeptide Y, have been used to optimize direct densitometry of PVDF membrane. For all peptides and proteins analyzed, the optical response of the instrument to peptide and protein bands in PVDF membrane wetted in 50% methanol was linear and highly reproducible. The method described here is useful for a rapid quantification of peptides and proteins on PVDF membrane and is an alternative to RIA, ELISA or bioassay.
Experimental Characterization of Inverse Dynamics Guidance in Docking with a Rotating Target (2016)

The performance of an inverse dynamics guidance and control strategy is experimentally evaluated for the planar maneuver of a “chaser” spacecraft docking with a rotating “target.” The experiments were conducted on an air-bearing proximity maneuver testbed. The chaser spacecraft simulator consists of a three-degree-of-freedom autonomous vehicle floating via air pads on a granite table and actuated by thrusters. The target consists of a docking interface mounted on a rotational stage with the rotation axis perpendicular to the plane of motion. Given a preassigned trajectory, the guidance and control strategy computes the required maneuver control forces and torque via an inverse dynamics operation. The recorded data of 150 experimental test runs were analyzed using two-way analysis of variance and post hoc Tukey tests. The metrics were maneuver success, vehicle mass change, maneuver duration, thruster duty cycle, and maneuver work. The results showed that the guidance and control algorithm provided robust performance over a range of target rotation rates from 1 to . The effects of the rate estimation errors are measurable but not dominant.
Association of HLA-G 3’ Untranslated Region Polymorphisms with Systemic Lupus Erythematosus in a Japanese Population: A Case-Control Association Study (2016)

HLA-G plays a role in fetal-maternal tolerance as well as immunoregulation, and has been suggested to be involved in autoimmune diseases and cancers. HLA-G encodes two potentially functional polymorphisms in the 3' untranslated region, 14bp insertion/deletion (14bp indel, rs371194629) and a single nucleotide polymorphism rs1063320, previously reported to affect HLA-G expression level or splicing isoform and to be associated with susceptibility to systemic lupus erythematosus (SLE). However, the results of SLE association studies are inconsistent, probably due to the small sample size of each study and lack of consideration of linkage disequilibrium (LD) with HLA-class II haplotypes in each population. In this study, we performed association studies of these polymorphisms on 843 patients with SLE and 778 healthy controls in a Japanese population, in many of whom HLA-DRB1 alleles have been genotyped at the four-digit level. LD was detected between DRB1*13:02, protective against multiple autoimmune diseases in the Japanese, and the rs1063320 G (D' = 0.86, r2 = 0.02) and with 14bp del (D' = 0.62, r2 = 0.01), but not between SLE-susceptible DRB1*15:01 and HLA-G. Although significant association with overall SLE was not detected, 14bp ins allele was significantly associated with SLE with the age of onset <20 years, when compared with healthy controls (P = 0.0067, PFDR = 0.039, OR 1.44, additive model) or with SLE patients with the age of onset ≥20 (P = 0.033, PFDR = 0.0495, OR 2.09, additive model). This association remained significant after conditioning on DRB1*13:02 or DRB1*15:01. On the other hand, significant association was detected between rs1063320 C and anti-RNP antibody and anti-Sm antibody positive SLE, which was dependent on negative LD with DRB1*13:02. eQTL analysis showed reduced HLA-G mRNA level in 14bp ins/ins individuals. In conclusion, our observations showed that HLA-G 14bp ins allele represents a genetic contribution on early-onset SLE independent of DRB1.
Modulation Classification Based on Signal Constellation Diagrams and Deep Learning (2018)

Deep learning (DL) is a new machine learning (ML) methodology that has found successful implementations in many application domains. However, its usage in communications systems has not been well explored. This paper investigates the use of the DL in modulation classification, which is a major task in many communications systems. The DL relies on a massive amount of data and, for research and applications, this can be easily available in communications systems. Furthermore, unlike the ML, the DL has the advantage of not requiring manual feature selections, which significantly reduces the task complexity in modulation classification. In this paper, we use two convolutional neural network (CNN)-based DL models, AlexNet and GoogLeNet. Specifically, we develop several methods to represent modulated signals in data formats with gridlike topologies for the CNN. The impacts of representation on classification performance are also analyzed. In addition, comparisons with traditional cumulant and ML-based algorithms are presented. Experimental results demonstrate the significant performance advantage and application feasibility of the DL-based approach for modulation classification.
Control and stability of power inverters feeding renewable power to weak AC grids with no or low mechanical inertia (2009)

The number of power inverter installations feeding renewable energy to AC grids is worldwide increasing. The type of inverter used depends on the power level and on the AC system conditions at the terminal connection point. Line-commutated inverters need sufficient short circuit power. Self-commutated inverters can even operate without an existing grid. In both the cases the mechanical inertia decreases in proportion to the installation of static generation. The main question to be answered is therefore: can inverters be equipped with electrical inertia so that the existing load-frequency controls will be maintained? This work combines an analytical approach using MATLAB with transient simulations using PSCAD/EMTDC. The results demonstrate that stability is achievable with no or low mechanical inertia. The results are relevant for distributed generation as well as for remote off-shore wind farms supplying bulk power via HVDC transmission systems into coastal areas.
The manifold backpropagation algorithm (1994)

This paper introduces a generalization of the concept of neural network by allowing the activation functions to be defined from a C/sup k/-manifold to a C/sup k/-manifold. Real-valued neural networks (RNN), complex-valued neural networks (CNN) as well as the recently introduced vector neural networks (VNN) can be seen as special cases of manifold neural networks (MNN). The classical back-propagation algorithm can be extended to manifolds, assuming some hypothesis on the order of differentiability and on some global properties of the manifold, The case of analytic manifolds are briefly discussed as well as the case of manifolds with boundaries.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Use of fire in land clearing: Controlled burns by planned application and confinement of fire to preselected wildland area a tool of many uses (1951)

The first of five articles reporting the findings in investigations in the effectiveness, the safety and the cost of the use of controlled burning as a tool for land clearing. No attempt is made to provide one formula for prescribed burning in California; each fire is an individual case to be planned on the ground.
Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients (2019)

Impaired TRPM3 activity was validated in NK cells isolated from CFS/ME patients using different pharmacological tools and whole-cell patch-clamp technique as the gold standard for ion channel research. This investigation further helps to establish TRPM3 channels as a prognostic marker and/ or a potential therapeutic target for CFS/ME.
Speech compression using pitch synchronous interpolation (2002)

This paper presents a new time-domain algorithm for compressing speech signals. Using a novel tool which we will refer to as time weighted average (TWA), a periodically extendable pitch cycle is extracted from the voiced regions in the speech signal. This procedure is carried out every x/sup th/ pitch period. The discarded x-1 pitch periods are recovered using pitch synchronous interpolation (PSI). The computational complexity of the resulting decoder is surprisingly modest and shows reasonable potential of implementation on hardware as primitive as the Intel 8088 /spl mu/-processor. Simulation results show that the reconstruction quality is comparable to G.721.
A proposed structure for collector transit-time reduction in AlGaAs/GaAs bipolar transistors (1986)

The impact of velocity overshoot in the collector space-charge region on carrier transport is explored. The effects of overshoot on transit time for conventional collector structures are found to be minor. A new collector structure which exhibits extended velocity overshoot is proposed. This structure promises both simple fabrication and significant improvements (≃ 25 percent) in carrier transit time over conventional collector structures as demonstrated by Monte Carlo simulation.
Treatment Effects in Patients with Squamous Cell Carcinoma of the Oral Cavity (2002)

A total of 221 patients (155 males, 66 females; stage I, n = 55: stage II, n = 58; stage III, n = 57; stage IV, n = 51) with squamous cell carcinoma of the oral cavity were studied. Tumor localization was as follows: cancer of the tongue, n = 161; cancer of the oral floor, n = 28; cancer of the hard palate, n = 12; cancer of the buccal mucosa, n = 11; and cancer of the gingiva, n = 9. In order to compare the effect of different treatments, three major treatment groups were defined, namely a surgery group, a radiotherapy group and a combination treatment group. Five-year cumulative survival rates showed significant differences between stage classifications (stage I = 91%, stage II = 73%, stage III = 63%, stage IV = 47%; p < 0.01) but not between tumor sites. The 5-year cumulative survival rate was highest for oral floor cancer (80%). In the early-cancer group, the 5-year cumulative survival rate for the surgery group (92%) was significantly higher (p < 0.05) than those for both the radiation (69%) and combination (71%) groups. In the advanced-cancer group, the 5-year cumulative survival rate for the surgery group (74%) was significantly higher (p < 0.05) than those for both the radiation (37%) and combination (51%) groups. No significant difference in regional control rates was observed between the treatment groups. Five-year regional control rates were 86% for cervical untreated patients with T1N0 tumors and 60% for cervical untreated patients with T2N0 tumors. Fourteen N0 cases were treated with neck dissection. Cervical metastasis was found pathologically in 2/14 (14%) of these cases. The 5-year survival rate for patients with cervical recurrences after primary tumor resection was 70% (n = 15). In contrast, the 5-year survival rate for patients with both primary tumor resection and neck dissection was 74% (n = 14) but no significant difference was observed between these 2 groups.
Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. (1995)

Altered membrane polarity has been proposed as an important pathogenetic factor in the development of renal cysts in polycystic kidney disease. To determine whether this alteration in epithelial phenotype is a primary or secondary phenomenon, we examined the epithelial membrane polarity of SBM transgenic mice, in which epithelial proliferation mediated by the c-myc oncogene is an established primary event. Kidneys from 32 transgenic mice and 10 age-matched controls from fetal to adult age were immunostained with antibodies to Na,K-ATPase, fodrin, ankyrin, E-cadherin, and tubule segment-specific lectins. In normal control mice, Na,K-ATPase localization was apical in fetal kidneys but became translocated to the basolateral membrane at maturity. Early microcysts in fetal transgenic kidneys displayed similar (95 to 100%) apical Na,K-ATPase. In young and newborn transgenic mice (1 to 8 days of age), Na,K-ATPase localization was extremely heterogeneous. Noncystic tubules demonstrated either apical (mean 23 to 28%), basolateral (mean 48 to 58%), mixed (mean 4 to 15%), or absent (mean 10 to 13%) staining for Na,K-ATPase. Apical Na,K-ATPase was more frequently observed in early cysts (mean 55%) in young transgenic mice but became less prevalent in adult mice (mean 22%), where 30% of cysts had basolateral staining, 39% mixed patterns, and 9% absent staining. Macrocysts typically lost all Na,K-ATPase reactivity. At all ages, Na,K-ATPase colocalized well with cytoskeletal proteins ankyrin and fodrin. These heterogeneous patterns of Na,K-ATPase staining indicate that although altered cell polarity is frequent in early cystic epithelium of SBM mice, it is not a prerequisite to cystogenesis or progressive cyst enlargement. In conclusion, our results support the view that altered cystic membrane polarity is not a primary process, but represents the persistence of an immature epithelial phenotype characteristic of proliferative polycystic kidney disease epithelia.
Etching of low loss mirrors for photonic ICs (2002)

The requirements for etching low loss mirrors and the dry etching techniques used for realizing these mirrors in photonic devices are reviewed. The effect of carbon dioxide and nitrous oxide additions to CH/sub 4//H/sub 2/ on the etch characteristics of double heterostructure layers is discussed. Vertical mirror profiles were obtained by using a CO/sub 2/ based etch process. Parabolic mirror elements having 1.2 dB loss were etched in an integrated InGaAsP/InP demultiplexer by using a CH/sub 4//H/sub 2//CO/sub 2/ reactive ion etching process. Loading effects were found to be dominant in methane/hydrogen based processes and were found to affect verticality of the quaternary layers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A COMPLEX PROCESS OF THE DEVELOPMENT OF NEW ACETYLCHOLINESTERASE REACTIVATORS- FROM PREDICTION TO IN VIVO EVALUATION (2014)

The mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the irreversible inhibition of acetylcholinesterase that is followed by an accumulation of acetylcholine at peripheral and central cholinergic synapses, which in turn leads to the clinical manifestation of various signs and symptoms summarized as acute cholinergic crisis. Nerve agent poisoning is commonly treated using a combination of a cholinolytic drug to counteract the accumulation of acetylcholine at muscarinic receptors and acetylcholinesterase reactivators (pralidoxime or obidoxime) to reactivate nerve agent-inhibited acetylcholinesterase. There is a strong interest in developing new, more potent acetylcholinesterase reactivators. The development of acetylcholinesterase reactivators consists of several steps: description of nerve agent intoxication mechanism on molecular basis (molecular design), prediction of biologically active structure of acetylcholinesterase reactivators (artificial neural networks), their synthesis, in vitro and in vivo evaluation of their potency to counteract acute toxicity of nerve agents.
Canography (Canon NP process) in electrophotography (1972)

A new system of electrophotography--the Canon NP process--is discussed. A photosensitive member comprising an insulating layer, a photoconductive layer, and a conductive layer is used in this process. The procedure for the formation of latent images consists of three steps: 1) primary charging, 2) image exposure with ac corona discharging, and 3) blanket exposure. The principle of image formation can be explained by a simple RC equivalent circuit representing the insulating layer, the photoconductive layer, and the air gap, etc. The influence of the thickness of the insulating layer on image quality can be represented by the response function of the NP plate. Sharpness and resolution calculated from the response function agree with the measured values. The NP plate has higher sensitivity than the conventional plate. This is explained by the fact that the electrostatic contrast required for development is obtained by a smaller amount of charge and that photoconductive layers of low resistance can be used. Since the NP process utilizes the injecting and rectifying properties of the photoreceptor, CdS or Se-Te alloys that are well known as one carrier photoreceptors can be used.
Neural Information Bottleneck Decoding (2020)

Receiver-sided channel decoding is a crucial, but computationally very demanding task. Recently, information-bottleneck-based decoding received considerable attention in the literature, as it achieves very good performance with coarse quantization and low complexity. Information bottleneck de-coders replace the conventional node operations in the channel decoders with relevant-information-preserving mappings. In the literature, these mappings are typically represented as lookup tables. Unfortunately, the lookup tables are fairly large and the logic circuits needed to implement the lookup tables occupy significant chip area. This paper proposes a novel approach to overcome these impairments, which is based on a trainable function, i.e., a neural network. We show that a trained neural network can represent the mappings more compactly than the frequently used lookup tables. Moreover, our results show that even multiple-input-multiple-output mappings can be learned to replace lookup tables with prohibitive complexity. We investigate a coarsely quantized low-density parity-check decoder that realizes the relevant-information-preserving mappings for all decoding iterations with a single neural network to illustrate the practical benefits of the proposed concept.
Advances in the understanding and treatment of obesity (1999)

The epidemic of obesity in the United States has major consequences for society. Healthcare providers need to have an appreciation for obesity's complexity and related multiple comorbid medical problems. This article reviews the epidemiology, definitions, and assessment of obesity with emphasis on its clinical consequences. In addition, current techniques in evaluating and treating the obese patient are also described.
Development of a bioengineered tissue model and its application in the investigation of the depth selectivity of polarization gating (2005)

Understanding the propagation of polarized light in tissue is crucial for a number of biomedical optics applications. Here we report the development of a bioengineered connective tissue model fabricated by the combination of scaffolding and cross-linking techniques to study light transport in biological tissue. It demonstrates great similarity to real connective tissue in its optical properties as well as microarchitecture. Moreover, the optical properties of the model can be reproducibly controlled. As an example, we report the utilization of this model to study the effect of epithelium and the underlying connective tissue on the depth selectivity of polarization gating.
A Non-Ouabain Na/K Atpase Inhibitor Isolated from Bovine Hypothalamus. Its Relation to Hypothalamic Ouabain (1998)

We have isolated from bovine hypothalamic and pituitary tissue the sodium pump inhibitor HHIF that is structurally different from ouabain. By mass spectrometric analysis this purified factor revealed a single unique molecular ion with an accurate mass of 412.277 and a mass spectra different from ouabain. It has been previously shown that HHIF inhibits the Ca2+-ATPase of the plasma membrane of synaptosomes. HHIF increases free calcium levels in cultured rat mesangial cells as well as mesangial cell contraction and proliferation. With the same purification procedure we have isolated in parallel HHIF and Ouabain from central nervous tissue. Ouabain elutes prior to HHIF in the final purification HPLC systems. This endogenous Ouabain has, in all the systems tested, the same chromatographic behavior that synthetic cold or [3H] Ouabain.
Measuring Phase Synchronization of Superimposed Signals (2005)

Phase synchronization is an important phenomenon that occurs in a wide variety of complex oscillatory processes. Measuring phase synchronization can therefore help to gain fundamental insight into nature. In this Letter we point out that synchronization analysis techniques can detect spurious synchronization, if they are fed with a superposition of signals such as in electroencephalography or magnetoencephalography data. We show how techniques from blind source separation can help to nevertheless measure the true synchronization and avoid such pitfalls.