gebhart/patrepeval huggingface dataset:
Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results (2006)

Cyclooxygenase-2 (COX-2) is overexpressed in lung cancer, especially in adenocarcinoma (ADC). Our aim was to determine the prognostic value of COX-2 on survival in patients with lung cancer. Studies evaluating the survival impact of COX-2 in lung cancer, published until December 2005, were selected. Data for estimation of individual hazard ratios (HR) for survival were extracted from the publications and combined in a pooled HR. Among 14 eligible papers, all dealing with non-small-cell lung cancer, 10 provided results for meta-analysis of survival data (evaluable studies). Cyclooxygenase-2 positivity was associated with reduced survival, improved survival or no statistically significant impact in six, one and seven studies, respectively. Combined HR for the 10 evaluable studies (1236 patients) was 1.39 (95% confidence intervals (CI): 0.97-1.99). In stage I lung cancer (six evaluable studies, 554 patients), it was 1.64 (95% CI: 1.21-2.24). No significant impact was shown in ADC. A slight detrimental effect on survival in patients with lung cancer is associated with COX-2 expression, but the statistical significance is not reached. This effect is statistically significant in stage I, suggesting that COX-2 expression could be useful at early stages to distinguish those with a worse prognosis.
An Efficient IEEE 802.11 ESS Mesh Network Supporting Quality-of-Service (2006)

IEEE 802.11 infrastructure basic service set (BSS) wireless local area networks (WLANs) are widely used, each comprising an access point (AP) and its associated stations. There is a need to interconnect BSSs wirelessly to create an extended service set (ESS) mesh network. We propose a solution for the architecture and protocols of a mesh distributed coordination function (MDCF) to interconnect a large number of APs in order to form an efficient ESS mesh network under distributed control. MDCF applies time-division multiple access to share the radio medium and is able to run on a single frequency channel on top of the IEEE 802.11a/b/g physical layers, concurrently to legacy stations. MDCF is capable to efficiently exploit channel capacity, fairly distribute bandwidth among the mesh points and support multihop relaying of a large number of concurrent traffic flows strictly observing specific quality-of-service requirements. Example simulation results proof the outstanding performance of the new concept proposed
Acetonobutylic fermentation: Improvement of performances by coupling continuous fermentation and ultrafiltration (1986)

The technology of coupling ultrafiltration and fermentation has been tested with the acetonobutylic fermentation in continuous mode. The device developed was sterilizable by steam and permitted drastic cleaning of the ultrafiltration (UF) membrane without interrupting the continuous fermentation. It has been shown to be an easily operated and reliable experimental tool for studying high-cell-density cultures and inhibition phenomena. With total recycle of biomass, a dry weight concentration of 125 g/L was attained, which greatly enhanced the volumetric solvent productivity of acetonobutylic fermentation in averaging 4. 5 g/L h for significant periods of time (>70 h) and maintaining solvent concentration and yield at acceptable levels.
Experimental diabetic neuropathy: impairment of slow transport with changes in axon cross-sectional area. (1985)

Analysis of slow axonal transport in the sciatic and primary visual systems of rats with streptozotocin-induced diabetes of 4-6 weeks duration showed impairment of the transport of neurofilament subunits, tubulin, actin, and a 30- and a 60-kDa polypeptide in both systems. The degree of impairment was not uniform. Transport of polypeptide constituents of the slow component b, such as the 30- and 60-kDa polypeptides, appeared to be more severely affected than the transport of constituents of the slow component a, such as neurofilaments. Morphometric analysis of sciatic axons revealed a proximal increase and a distal decrease of axonal cross-sectional area. It is proposed that impairment of axoplasmic transport and changes of axonal size are related. Transport impairment results in a larger number of neurofilaments, microtubules, and other polypeptides in the proximal region of the axon, which increases in size, whereas fewer neurofilaments, microtubules, and other polypeptides reach the distal axons that show a size decrease. Such changes in axonal transport and area are likely to occur in other diabetic animal models and in human diabetes.
A Structural Health Monitoring Software Tool for Optimization, Diagnostics and Prognostics (2011)

Development of robust structural health monitoring (SHM) sensors and hardware alone is not sufficient to achieve desired benefits such as improved asset availability and reduced sustainment costs. For SHM systems to be practically deployed as part of an integrated system health management (ISHM), tools must be created for SHM life- cycle management (LCM). To that end, SHM-LCM software has been developed to expedite the adoption of SHM into ISHM. The SHM-LCM software is a flexible application intended to manage the cradle-to-grave life- cycle of an SHM system for generic applications. There are 4 core modules to facilitate critical roles: Optimization, Calibration, Visualization, and Action. The Optimization module seeks to devise optimal sensor placement and excitation parameters in order to achieve probability of detection (POD) coverage requirements. The Calibration module is designed to guide a user through a series of material level tests in order to customize algorithm variables to the system being designed. The Visualization module is dedicated to generating a diagnostic composite picture based on data downloaded from the diagnostic server, which is “stitched” to the original 3D mesh, providing users with a manipulatable GUI to toggle between probability of damage distributions for various calibrated damage modes. Finally, The Action module generates residual performance plots (ultimate load or deflection for example) as a function of probability of damage, so detection confidence can be weighed against impact to the vehicle’s capabilities. SHM- LCM software will enable SHM systems to be incorporated into ISHM by engineers rather than experts, making the technology more accessible, and commercially practical.
Etude de couches de chromatation sur acier revêtu par spectroscopies FTIR et Raman ; application aux propriétés d’adhérence (1995)

Les techniques de micro-spectrométrie FTIR et Raman ont été développées pour l’analyse de couches de chromatation sur acier revêtu. L’objectif a été dans un premier temps de mettre au point tes conditions d’utilisation optimales pour caractériser ces couches, et dans un deuxième temps d’appliquer ces développements à l’étude des corrélations entre la nature locale du film organique ou inorganique après rupture mécanique, et les propriétés d’adhérence.
Capacity analysis of MIMO systems with unknown channel state information (2005)

We consider a mobile wireless communication system composed of M transmit and N receive antennas operating in a fading environment. Assuming channel state information is unavailable to the transmitter and the receiver, a capacity upper bound of the unknown MIMO channel under the assumption of restricted input distributions is provided. By analyzing the proposed capacity upper bounds, we reinforce the advantages of using an orthogonal pilot structure which minimizes the mean square estimation error, in that it also maximizes the capacity upper bounds. Interestingly, the capacity upper bound is shown to be a monotonically decreasing function with respect to the number of pilot symbols, T/sub /spl tau//. Numerical evaluations of the capacity upper bound further demonstrate that the capacity gain is insignificant when T/sub /spl tau// decreases below M, suggesting an optimum training duration of M time slots.
Photoinduced Hydrophilicity of Heteroepitaxially Grown ZnO Thin Films (2005)

Single crystalline ZnO thin films were heteroepitaxially grown on sapphire substrates by rf-magnetron sputtering. The ZnO films on sapphire A and C face were oriented along the (0001) direction, whereas the ZnO film on sapphire R face was oriented along the (11-20) direction. The rate of photoinduced hydrophilic conversion strongly depended on the surface crystal structure. The ZnO film oriented along the (11-20) direction exhibited a higher hydrophilicizing rate than those oriented along the (0001) direction. The high hydrophilicizing rate of the ZnO oriented along the (11-20) direction is due to its surface atomic arrangement. The outermost layer of the ZnO surface of the (11-20) face contains oxygen ions, which are considered to be energetically reactive sites and responsible for the hydrophilic conversion.
Design Parameters for Comfortable and Safe Vehicle Seats (1997)

<div class="htmlview paragraph">This paper discusses design parameters for automotive seats intended to simultaneously meet three design objectives: comfort, safety, and health. (“Health” refers to long-term spinal support and vibration attenuation.)</div> <div class="htmlview paragraph">For comfort, various ergonomic and human factors considerations are discussed ranging from seat dimensions and adjustments to cushioning and occupant perceptions of comfort. For safety, the principal consideration is the effectiveness of the seat in providing spinal support during accidents-particularly in rear-end collisions. An additional safety consideration is the ability of the seat to keep an occupant “in position” during an accident. Finally, for health concerns, the focus is upon maintenance of spinal stability, seat ergonomics, and road induced vibration attenuation.</div> <div class="htmlview paragraph">The paper presents design parameters satisfying these design objectives. These parameters include seat dimensions and their adjustments; cushioning for vibration suppression; fabric design to help maintain occupant position during periods of high acceleration; back rest strength for thoracic and lumbar spine protection; and head rest geometry for cervical spine protection.</div>
Sintering of Lithium Zinc Ferrites with Alkoxide‐Derived Borosilicate Liquid Phase (1991)

Lithium zinc ferrites (Li 0.3 Zn 0.4 Mn 0.05 Fe 2.25 O 4 ) of > 97% theoretical density were prepared with alkoxide‐derived borosilicate sintering additive. A sol‐gel technique was used to incorporate the borosilicate phase prior to sintering. The effects of borosilicate composition and additive quantity on microstructural development and densification are reported. Direct current resistivity, dynamic hysteresis, and microwave property data are discussed in terms of processing parameters and resultant microstructures. The microstructure of the sintered ferrites was analyzed using SEM and TEM. Heterogeneities including regions of liquid‐phase coalescence and intragranularly included glass phase were observed in some cases. These microstructural features were shown to have deleterious effects on microwave magnetic properties when compared to those of commercial ferrites of the same nominal composition sintered with Bi 2 O 3 additive.
<i>E</i>- or<i>Z</i>-Selective Knoevenagel Condensation of Acetoacetic Derivatives:  Effect of Acylated Substituent, that is, TEMPO and Amines, as an Auxiliary, and New Accesses to Trisubstituted<i>E</i>- and<i>Z</i>-2-Alkenals and Furans (2006)

Knoevenagel condensation of O-acetoacetylTEMPOs (2,2,6,6-tetramethylpiperidine-1-oxyl) with aldehydes substituted with an electron-withdrawing group such as aromatic and heteroaromatic ones leads preferentially to E-adducts, while acylacetoamides including Weinreb amides produce Z-adducts, exclusively. These E- and Z-adducts are selectively converted to the corresponding (2E)- and (2Z)-2-hyroxyalkyl-2-alkenals, respectively, by stepwise reductions of the acyl group with DIBALH and then the carboxylic functions after protection of the hydroxy group. Transformation of the Knoevenagel products by taking advantage of the E-geometry to trisubstituted furans is also developed.
Face Presentation Attack with Latex Masks in Multispectral Videos (2017)

Face recognition systems are susceptible to presentation attacks such as printed photo attacks, replay attacks, and 3D mask attacks. These attacks, primarily studied in visible spectrum, aim to obfuscate or impersonate a person's identity. This paper presents a unique multispectral video face database for face presentation attack using latex and paper masks. The proposed Multispectral Latex Mask based Video Face Presentation Attack (MLFP) database contains 1350 videos in visible, near infrared, and thermal spectrums. Since the database consists of videos of subjects without any mask as well as wearing ten different masks, the effect of identity concealment is analyzed in each spectrum using face recognition algorithms. We also present the performance of existing presentation attack detection algorithms on the proposed MLFP database. It is observed that the thermal imaging spectrum is most effective in detecting face presentation attacks.
Algorithm for Estimation of the Specific Differential Phase (2009)

Abstract The specific differential phase Kdp is one of the important parameters measured by dual-polarization radar that is being considered for the upgrade of the current Next Generation Weather Radar (NEXRAD) system. Estimation of the specific differential phase requires computing the derivative of range profiles of the differential propagation phase. The existence of possible phase wrapping, noise, and associated fluctuation in the differential propagation phase makes the evaluation of derivatives an unstable numerical process. In this paper, a robust algorithm is presented to estimate the specific differential phase, which is able to work on wrapped phases and keep up with the spatial gradients of rainfall, to provide a high-resolution specific differential phase.
Anti-Timothy IgE Formation: Suppression with Antigen D-dGl Conjugates (1980)

Antigen D fragments (AgD1 and AgD2) and chemically synthesized quercetin-glutathione were conjugated to the synthetic polypeptide copolymer of D-glutamic acid and D-lysine (dGL). These conjugates were tested at varying epitope densities to determine their ability to suppress a secondary anti-antigen B IgE response. The data showed that all of the conjugates used with epitope densities of 5-20 groups per dGL produced significant dose-dependent suppression of a secondary IgE response. The duration of the observed suppression was short (about 30 days), but could be extended by additional treatment with the conjugate prior to the loss of unresponsiveness.
A Fast-Settling Wideband-IF ASK Baseband Circuit for a Wireless Endoscope Capsule (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A novel automatic-gain-control (AGC) architecture utilizing wideband current feedback is proposed for the baseband circuit of a wireless endoscope capsule. The baseband circuit consists of a fast-settling wideband AGC loop and an amplitude-shift-keying demodulator. Additional integrators in the reverse signal path provide negative feedback, bandpass-filtering effect, attenuating low-frequency noises, and dc offset from the radio-frequency front end. The baseband circuit fabricated in a 180-nm complementary metal–oxide–semiconductor process achieves a wide-intermediate-frequency (IF) carrier frequency in the range of 0.5–40 MHz, a measured settling time of 2 <formula formulatype="inline"><tex Notation="TeX">$\mu\hbox{s}$</tex></formula>, and an input sensitivity of <formula formulatype="inline"><tex Notation="TeX">$-$</tex></formula>57 dBm. The entire baseband demodulator dissipates only 5 mA, with a 1.8-V supply at a data rate of 1.37 Mb/s and an IF carrier frequency of 10 MHz. </para>
Open Science for the Neuroinformatics community (2018)

The Neuroinformatics community in OpenAire-Connect is represented by members of the France Life Imaging (FLI) collaboration. In this context, we aim at leveraging OpenAire-Connect services and give our community members the possibility to easily publish and exchange research artefacts from FLI platforms, such as VIP and Shanoir. This will enable open and reproducible science, since literature, data, and methods can be linked, retrieved, and replayed by all the members of the community.
Differences in oxidative stress markers based on the aetiology of heart failure: Comparison of oxidative stress in patients with and without coronary artery disease (2009)

Various oxidative stress markers have been measured to evaluate the status of heart failure (HF). However, the relationships between these markers and the aetiology of HF have not been fully investigated. This study compared 8-hydroxy-2'-deoxyguanosine (8-OHdG) and biopyrrins levels in patients with ischemic and non-ischemic HF. Study subjects were divided into a coronary artery disease (CAD) group (n=70), a non-CAD group (n=61) and a control group (n=33). In the CAD group, 8-OHdG and biopyrrins levels increased with the severity of the New York Heart Association (NYHA) functional class and log BNP levels correlated with 8-OHdG and biopyrrins levels. However, non-CAD patients with NYHA class III/IV had significantly lower 8-OHdG levels than CAD patients with NYHA class III/IV and the levels did not correlate with log BNP levels. In the CAD group, 8-OHdG levels reflected the severity of atherosclerosis. These results indicate that the properties of oxidative stress markers should be carefully taken into consideration for the assessment of HF status.
Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls (2000)

Cytochrome P4501B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones, including 17beta-oestradiol (E2) and testosterone. We report a significant difference in the allele frequencies of two point mutations in the coding region of the CYP1B1 gene among Caucasian (n = 189), African-American (n = 52) and Chinese (Linxian) (n = 109) populations. A (C to G) transversion at position 1666 in exon 3, which results in an amino acid substitution of Leu432 to Val, was present in African-Americans with an allele frequency for Va1432 of 0.75, in Caucasians of 0.43, and in Chinese of 0.17. A (C to T) transition at position 1719 in exon 3, with no amino acid change (Asp449), appeared to be closely linked with the Val432 variant. Results using human lung microsomal preparations from individuals with the CYP1B1Val/Val and CYP1B1Leu/Leu genotypes indicate that Val432 variant may be a high activity allele and thus may contribute to the interindividual differences in CYP1B1 activity. Because CYP1B1 is involved in hormone and carcinogen metabolism, and given the disparate rates of prostate cancer among ethnic groups, we also evaluated the association of the CYP1B1 Leu432Val polymorphism with prostate cancer risk in a pilot case-control study. Among Caucasians, 34% of men with cancer (n = 50) were homozygous for the Val432 polymorphism, while only 12% of matched control subjects (n = 50) had this genotype. These preliminary data indicate that genetic polymorphisms in CYP1B1 might play an important role in human prostate carcinogenesis.
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model (2003)

Tau protein hyperphosphorylation and aggregation into neurofibrillary tangles are characteristic features of several neurodegenerative disorders referred to as tauopathies. Among them, frontotemporal dementia and Parkinsonism linked to chromosome 17 may be caused by dominant missense mutations in the tau gene. Transgenic mice expressing mutant tau serve as valid model systems to study the ethiopathogenesis of these diseases and assay possible therapeutic interventions. Here we report that chronic lithium treatment of a transgenic mouse strain expressing human tau with three missense mutations results in decreased glycogen synthase kinase-3-dependent-tau phosphorylation and a reduction of filamentous aggregates. These data indicate that lithium, presumably acting through the inhibition of glycogen synthase kinase 3, may be useful to curb neurodegeneration in tauopathies.
The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer (2008)

The significance of the inter-relationship between tumour and host local/systemic inflammatory responses in primary operable invasive breast cancer is limited. The inter-relationship between the systemic inflammatory response (pre-operative white cell count, C-reactive protein and albumin concentrations), standard clinicopathological factors, tumour T-lymphocytic (CD4+ and CD8+) and macrophage (CD68+) infiltration, proliferative (Ki-67) index and microvessel density (CD34+) was examined using immunohistochemistry and slide-counting techniques, and their prognostic values were examined in 168 patients with potentially curative resection of early-stage invasive breast cancer. Increased tumour grade and proliferative activity were associated with greater tumour T-lymphocyte (P<0.05) and macrophage (P<0.05) infiltration and microvessel density (P<0.01). The median follow-up of survivors was 72 months. During this period, 31 patients died; 18 died of their cancer. On univariate analysis, increased lymph-node involvement (P<0.01), negative hormonal receptor (P<0.10), lower albumin concentrations (P<0.01), increased tumour proliferation (P<0.05), increased tumour microvessel density (P<0.05), the extent of locoregional control (P<0.0001) and limited systemic treatment (P<or=0.01) were associated with cancer-specific survival. On multivariate analysis of these significant covariates, albumin (HR 4.77, 95% CI 1.35-16.85, P=0.015), locoregional treatment (HR 3.64, 95% CI 1.04-12.72, P=0.043) and systemic treatment (HR 2.29, 95% CI 1.23-4.27, P=0.009) were significant independent predictors of cancer-specific survival. Among tumour-based inflammatory factors, only tumour microvessel density (P<0.05) was independently associated with poorer cancer-specific survival. The host inflammatory responses are closely associated with poor tumour differentiation, proliferation and malignant disease progression in breast cancer.
Soy Protein in the Management of Hyperlipidemia (2000)

OBJECTIVE:To review the effects of soy on blood lipids and to provide guidance on the clinical relevance of soy's health effects with respect to hyperlipidemia.DATA SOURCES:Clinical literature accessed through MEDLINE and EMBASE (1966–November 1999). Key search terms included soy, isoflavone, phytoestrogen, cholesterol, and blood lipids.DATA SYNTHESIS:A review of studies evaluating the effects of soy protein on blood lipids was undertaken. Soy may be an alternative for patients seeking modest reductions in low-density lipoprotein cholesterol (<10%).CONCLUSIONS:Soy can improve blood lipid parameters in both normocholesterolemic and hypercholesterolemic subjects, although the use of soy alone may not allow patients with hyperlipidemia to achieve target lipid parameters, as indicated by the National Cholesterol Education Program. Further study is warranted for the use of soy in combination with traditional hyperlipidemic medications.