gebhart/patrepeval huggingface dataset:
A substituent constant analysis of the interaction of substituted naphthalene monoimides with DNA (1984)

In a continuing analysis of substituent effects in intercalator-DNA interactions, an unsubstituted naphthalene monoimide, with a 3-(dimethylamino)propyl group on the imide nitrogen has been prepared along with 3- and 4-nitro- and 3- and 4-amino-substituted derivatives. These derivatives allow an evaluation of the importance of the Hammett substituent constant and of the substituent position on the binding of naphthalene monoimides to DNA. Viscosity and spectrophotometric analyses indicate that all five compounds bind to DNA by intercalation. The 4-nitro compound gives a smaller viscosity increase and binds only approximately one-third as strongly as the 3-nitro derivative. It is postulated that this difference is due to the significant angle that the 4-nitro group makes with the intercalated monoimide ring system. The 3-NO2 group can assume a coplanar configuration with the monoimide ring system, allowing more favorable interactions with DNA base pairs, larger viscosity increases, and stronger binding to DNA. The binding constants of the 3-substituted monoimides are in the order 2 greater than 4 greater than 1 and, thus, do not follow a substituent constant pattern. The Tm values from thermal melting of DNA, on the other hand, are in the order 2 greater than 1 greater than 4, suggesting that the enthalpy contributions are significantly different for the binding of the three compounds to DNA. van't Hoff plots support this finding and indicate that both enthalpy and entropy contribute significantly to the binding free energy of 1 and 2 while the binding of 4 is primarily an enthalpic process. Plots of Tm and 65 degrees C log K values as a function of substituent constant for 1, 2, and 4 are linear. CPK model building studies suggest that 4 can form a hydrogen bond with the 5' diester oxygen of the sugar-phosphate backbone of DNA in an intercalation complex. This would lead to more favorable energetics of binding but a loss of mobility and/or available binding configurations with a resulting enthalpy-entropy compensation in the binding free energy of 4. This series of compounds dramatically illustrates the steric and hydrogen bonding complexity that can arise in attempts to design drugs to favorably interact with a DNA intercalation site as a potential bioreceptor.
Asynchronous operations in distributed concurrency control (2003)

Distributed locking is commonly adopted for performing concurrency control in distributed systems. It incorporates additional steps for handling deadlocks. This activity is carried out by methods based on wait-for-graphs or probes. The present study examines detection of conflicts based on enhanced local processing for distributed concurrency control. In the proposed "edge detection" approach, a graph-based resolution of access conflicts has been adopted. The technique generates a uniform wait-for precedence order at distributed sites for transactions to execute. The earlier methods based on serialization graph testing are difficult to implement in a distributed environment. The edge detection approach is a fully distributed approach. It presents a unified technique for locking and deadlock detection exercises. The technique eliminates many deadlocks without incurring message overheads.
Tannins in black-plum (<i>Syzygium cumini</i> L.) seeds (1972)

Research Article| June 01 1972 Tannins in black-plum (Syzygium cumini L.) seeds I S Bhatia; I S Bhatia Search for other works by this author on: This Site PubMed Google Scholar K L Bajaj K L Bajaj Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 128 (1): 56P. https://doi.org/10.1042/bj1280056Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation I S Bhatia, K L Bajaj; Tannins in black-plum (Syzygium cumini L.) seeds. Biochem J 1 June 1972; 128 (1): 56P. doi: https://doi.org/10.1042/bj1280056Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 London: The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
Influence of time, temperature, moisture, ingredients, and processing conditions on starch gelatinization (1984)

Starch gelatinization phenomena is extremely important in many food systems. This review focuses on factors affecting gelatinization characteristics of starch. Important variables which must be considered in design of processes in which starch undergoes gelatinization are heat of gelatinization and temperature of gelatinization. Major interactions are reviewed for the effects of lipids, moisture content, nonionic constituents and electrolytes on these characteristics. Furthermore, treatment of starch-containing systems prior to heating into the gelatinization temperature range can have a significant effect on ultimate gelatinization characteristics.
A comparison of linear FBMC and circularly shaped waveforms (2016)

This paper presents a comparison of the conventional filter bank multicarrier (FBMC) with the generalized frequency division multiplexing (GFDM) and cyclic FBMC (C-FBMC) that have recently been proposed as waveforms candidates for 5G. We identify situations where FBMC outperforms GFDM/C-FBMC, as well as the cases where GFDM/C-FBMC provide more flexibility than FBMC.
Novel frequency-selective twist polariser (1991)

A new type of twist polariser that has a frequency selective property is investigated. The polariser consists of two sheets of photoetched dipole array FSSs, spaced about one-quarter wavelength apart. Such a polariser reflects waves at the desired frequency band in the usual manner, but lets the other frequency waves pass through.
Chemical durability of Y<sub>2</sub>O<sub>3</sub>‐Al<sub>2</sub>O<sub>3</sub>‐SiO<sub>2</sub> glasses for the <i>in vivo</i> delivery of beta radiation (1993)

Microspheres made from Y2O3-Al2O3-SiO2 (YAS) glasses, which contain radioactive Y-90, are currently being used to treat liver cancer in humans, where their chemical durability is of prime importance. In deionized water or saline at 37 degrees C, the weight percent Yttrium (Y) dissolved from eight different YAS glasses ranged from only 0.02-0.13% of the total Y present and their dissolution rate was barely measurable, < or = 1.0 x 10(-9) g/cm2-min. The most chemically durable YAS glass was 17Y2O3-19Al2O3-64SiO2, mol%. The small amount of Y released from microspheres, 25-35 microns diameter, of this glass after corrosion in saline or deionized water at 37 degrees C was essentially the same as for bulk glass samples. Based on their excellent chemical durability, it is concluded that YAS glass microspheres are suitable for in vivo use.
Computer description of textured surfaces (1973)

This work deals with computer analysis of textured surfaces. Descriptions of textures are formalized from natural language descriptions. Local texture descriptions are obtained from the directional and non-directional components of the Fourier transform power spectrum. Analytic expressions are derived for orientation, contrast, size, spacing, and in periodic cases, the locations of texture elements. The local descriptions are defined over windows of varying sizes.
DUB-3, a Cytokine-inducible Deubiquitinating Enzyme That Blocks Proliferation (2004)

Previous studies have identified the DUB family of cytokine-regulated murine deubiquitinating enzymes, which play a role in the control of cell proliferation and survival. Through data base analyses and cloning, we have identified a human cDNA (DUB-3) that shows significant homology to the known murine DUB family members. Northern blotting has shown expression of this gene in a number of tissues including brain, liver, and muscle, with two transcripts being apparent (1.6 and 1.7 kb). In addition, expression was observed in cell lines including those derived from a number of hematopoietic tumors such as the Burkitt's lymphoma cell line RAJI. We have also demonstrated that DUB-3, which was shown to be an active deubiquitinating enzyme, is induced in response to interleukin-4 and interleukin-6 stimulation. Finally, we have demonstrated that constitutive expression of DUB-3 blocks proliferation and can initiate apoptosis in both IL-3-dependent Ba/F3 cells and NIH3T3 fibroblasts. These findings suggest that human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation.
Catalytic Stereoselective Glycosidation with Glycosyl Diphenyl Phosphates: Rapid Construction of 1,2‐<i>cis</i>‐α‐Glycosidic Linkages (2008)

A commercially available 0.1 M solution of HClO(4) in dioxane has been shown to catalyze the glycosidation of glycosyl diphenyl phosphates. The per-O-benzyl-protected glucosyl and galactosyl donors and the 3,4,6-tri-O-acetyl-2-azido-2-deoxygalactosyl donor each react with a range of acceptor alcohols in the presence of 0.05-0.2 equiv of HClO(4) in dioxane/Et(2)O (1:1) to afford glycosides in good yields with good to excellent alpha selectivities. The synthetic utility of this glycosidation method was demonstrated by a stereoselective synthesis of the alpha-galactosylceramide KRN7000, an activator of natural killer (NK) T cells through CD1d molecules.
GUIdock: Using Docker Containers with a Common Graphics User Interface to Address the Reproducibility of Research (2016)

Reproducibility is vital in science. For complex computational methods, it is often necessary, not just to recreate the code, but also the software and hardware environment to reproduce results. Virtual machines, and container software such as Docker, make it possible to reproduce the exact environment regardless of the underlying hardware and operating system. However, workflows that use Graphical User Interfaces (GUIs) remain difficult to replicate on different host systems as there is no high level graphical software layer common to all platforms. GUIdock allows for the facile distribution of a systems biology application along with its graphics environment. Complex graphics based workflows, ubiquitous in systems biology, can now be easily exported and reproduced on many different platforms. GUIdock uses Docker, an open source project that provides a container with only the absolutely necessary software dependencies and configures a common X Windows (X11) graphic interface on Linux, Macintosh and Windows platforms. As proof of concept, we present a Docker package that contains a Bioconductor application written in R and C++ called networkBMA for gene network inference. Our package also includes Cytoscape, a java-based platform with a graphical user interface for visualizing and analyzing gene networks, and the CyNetworkBMA app, a Cytoscape app that allows the use of networkBMA via the user-friendly Cytoscape interface.
Management (1993)

Who's the Boss? Leigh G. Anderson, MA, RN. is co-owner of The Centre for Plastic Surgery in San Bernardino, CA. Plastic Surgical Nursing welcomes Leigh G. Anderson, MA, RN, as its newest department editor. She comes to the position with an extensive background in the area of management, and has previously been published in the journal. She and her plastic surgeon husband own and operate The Centre for Plastic Surgery in San Bernardino. CA. The Centre is JCAHO. Medicare, and AAAPSF certified.
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus (1998)

Cowden disease, a dominantly inherited syndrome characterized by a variety of proliferative lesions and predisposition to breast and thyroid cancer, has recently been linked to the polymorphic marker D10S215 on chromosome segment 10q23. Loss of heterozygosity in prostate cancer is linked to the same marker, whereas loss of heterozygosity in glioblastoma, endometrial cancer, and other malignancies also localizes to this region. Most recently, a putative tumor suppressor gene (PTEN/MMAC1) has been identified in the region between D10S215 and an adjacent, more telomeric marker (D10S541) and was found to be altered in breast cancers, prostate cancers, and glioblastomas. We examined 22 invasive breast cancers for loss of heterozygosity in the 10q23 region and found loss in 41% (9/22). There were two distinct regions of loss, including one near the D10S541 marker, with an approximately equal frequency of deletion in each. The observed pattern of deletion is consistent with the presence of a tumor suppressor gene between D10S215 and D10S541. Most of the poorly differentiated carcinomas in the case collection showed loss of heterozygosity in the region near D10S215, suggesting that this loss correlates with a poor prognosis.
Eine neue Methode zur reduktiven Entfernung phenolischer Hydroxygruppen (1974)

Abstract Phenole können in einem zweistufigen Verfahren über ihre Isoharnstoffderivate dehydroxyliert werden. Die Phenole werden zunächst an Carbodiimide addiert und die dabei gebildeten O ‐Arylisoharnstoffe sodann bei Raumtemperatur hydrogenolytisch in die aromatischen Kohlenwasserstoffe und disubstituierte Harnstoffe gespalten. Die reduktive Spaltung ist gegen sterische Faktoren empfindlich. Der Prozeß kann auch in einem Eintopfverfahren durchgeführt werden.
Low Power, Biologically Benign NIR Light Triggers Polymer Disassembly (2011)

Near infrared (NIR) irradiation can penetrate up to 10 cm deep into tissues and be remotely applied with high spatial and temporal precision. Despite its potential for various medical and biological applications, there is a dearth of biomaterials that are responsive at this wavelength region. Herein we report a polymeric material that is able to disassemble in response to biologically benign levels of NIR irradiation upon two-photon absorption. The design relies on the photolysis of the multiple pendant 4-bromo7-hydroxycoumarin protecting groups to trigger a cascade of cyclization and rearrangement reactions leading to the degradation of the polymer backbone. The new material undergoes a 50% Mw loss after 25 sec of ultraviolet (UV) irradiation by single photon absorption and 21 min of NIR irradiation via two-photon absorption. Most importantly, even NIR irradiation at biologically benign laser power is sufficient to cause significant polymer disassembly. Furthermore, this material is well tolerated by cells both before and after degradation. These results demonstrate for the first time a NIR sensitive material with potential to be used for in vivo applications.
Observation of the Talbot Effect at Beamline 6C Bio Medical Imaging of the Pohang Light Source-II (2019)

The Talbot effect is used in novel contrast imaging techniques that measure X-ray refractions and scattering. We examined formation of periodic fringes by the Talbot effect at beamline 6C Bio Medical Imaging of the Pohang Light Source-II, a facility for synchrotron radiation X-ray imaging. Talbot fringes were not observable under a normal illumination condition at the beamline, but appeared when we made a narrow opening of a slit next to the synchrotron radiation source that should have improved the transverse coherency of the beam. The Talbot fringes were identified by comparison with a numerical simulation, and also measuring the fringe visibility at fractional Talbot distances using grating interferometry.
Vascular endothelial growth factor, a specific regulator of angiogenesis (1996)

Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells. Recent studies point to vascular endothelial growth factor as a major regulator of physiological angiogenesis, such as developmental and reproductive angiogenesis. In addition vascular endothelial growth factor appears to be a crucial mediator of blood vessel growth associated with tumors and proliferative retinopathies. Antivascular endothelial growth factor antibodies have the ability to suppress the growth of a variety of tumor cell lines in nude mice and can also inhibit angiogenesis in animal models of intra-ocular neovascularization. Furthermore vascular endothelial growth factor administration promotes collateral vessel growth and results in functional improvement in animal models of coronary or limb ischemia.
Automatically building research reading lists (2010)

All new researchers face the daunting task of familiarizing themselves with the existing body of research literature in their respective fields. Recommender algorithms could aid in preparing these lists, but most current algorithms do not understand how to rate the importance of a paper within the literature, which might limit their effectiveness in this domain. We explore several methods for augmenting existing collaborative and content-based filtering algorithms with measures of the influence of a paper within the web of citations. We measure influence using well-known algorithms, such as HITS and PageRank, for measuring a node's importance in a graph. Among these augmentation methods is a novel method for using importance scores to influence collaborative filtering. We present a task-centered evaluation, including both an offline analysis and a user study, of the performance of the algorithms. Results from these studies indicate that collaborative filtering outperforms content-based approaches for generating introductory reading lists.
Immune response during tumor therapy with antibody-superantigen fusion proteins (1996)

To engineer superantigens (SAg) to express tumor reactivity, we genetically fused the Fab-part of the tumor-reactive MAb C215 and the bacterial SAg staphylococcal enterotoxin A (SEA). Treatment of mice carrying established lung micrometastases of the C215-transfected syngeneic B16 melanoma with 3-4 daily injections of C215Fab-SEA resulted in strong antitumor effects, while only moderate effects were seen when treatment was given every 4th day (intermittent treatment). High serum levels of IL-2, TNF-alpha, IFN-gamma and strong induction of CTLs (cytotoxic T lymphocytes) were noted after priming with the fusion protein. T cells responded well to 3 daily injections of C215Fab-SEA and then gradually entered a hyporesponsive state, characterized by a reduced ability to produce IL-2, TNF-alpha and IFN-gamma and failure to mediate cytotoxicity in vitro. Intermittent treatment was characterized by increased levels of IL-10, concomitant with accentuated loss of IL-2, TNF-alpha and IFN-gamma production. A 10-fold increase in SEA-reactive TCR V(beta)3+ CD4+ cells was observed in the spleen, while a loss of TCR V(beta)3+ CD8+ and V(beta)11+ CD8+ cells was noted. This is in striking contrast to injections of native SEA which induced a marked deletion of TCR V(beta)3+ CD4+ T cells, but not of CD8+ cells. Recovery of the TH1 cytokine profile occurred within 1-2 weeks, while restoration of cytotoxicity required several months and correlated with recovery of TCR V(beta)3+ CD8+ and TCR V(beta)11+ CD8+ T cells. These results show that the temporal relationship of SAg stimulations dictates the cytokine profile. Moreover, different mechanisms appear to regulate hyporesponsiveness in CD4+ and CD8+ T cells.
Robust Steering Control for Active Rollover Avoidance of Vehicles with Elevated Center of Gravity (1998)

Active safety technologies for reduction of rollover risk are dealing until now primarily with active suspension systems. In this paper a new vehicle dynamics approach is investigated, in which robust steering control is applied to avoid rollovers of vehicles with a high center of gravity. In addition to the driver&apos;s steering angle a small auxiliary steering angle is set by an actuator. The control law is based on proportional feedback of the roll rate and the roll acceleration. The parameter space approach helps to design a controller robust w.r.t. the vehicle&apos;s velocity and the uncertain height of the center of gravity. The closed loop system is analysed in time and frequency domain by step responses and sensitivity functions and compared with the conventional system. 1 Introduction Accident analysis [1, 2] of vehicles with an elevated center of gravity (CG) suggest a distinction between two major rollover categories. These are rollovers caused by maneuvers on plane surface and trip...
Light-growth responses of coastal Douglas-fir and western redcedar saplings under different regimes of soil moisture and nutrients (2001)

We characterized the radial and height growth response to light for coastal Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco var. menziesii) and western redcedar (Thuja plicata Donn ex D. Don) saplings growing in sites of different regimes of soil moisture and nutrients on the east coast of Vancouver Island, British Columbia. We determined that at low light levels, site quality has little effect on the growth response of Douglas-fir saplings. At light levels above approximately 40 and 60% full sun, Douglas-fir saplings show statistically significant differences in height and radial growth, respectively, that reflect the differences in soil moisture and nutrient regimes of the sites we examined. Western redcedar approaches its maximum radial and height growth rates at about 30% full sun. Our data suggest that partial-cutting treatments need to create light environments greater than about 40% full sun to achieve growth that represents a high proportion of the site growing potential for Douglas-fir at full sun, while the high shade tolerance of western redcedar allows silvicultural treatments that retain a high amount of forest structure without compromising growth rates of young trees.
The importance of filamentous cyanobacteria in the development of oxygenic photogranules (2017)

Microorganisms often respond to their environment by growing as densely packed communities in biofilms, flocs or granules. One major advantage of life in these aggregates is the retention of its community in an ecosystem despite flowing water. We describe here a novel type of granule dominated by filamentous and motile cyanobacteria of the order Oscillatoriales. These bacteria form a mat-like photoactive outer layer around an otherwise unconsolidated core. The spatial organization of the phototrophic layer resembles microbial mats growing on sediments but is spherical. We describe the production of these oxygenic photogranules under static batch conditions, as well as in turbulently mixed bioreactors. Photogranulation defies typically postulated requirements for granulation in biotechnology, i.e., the need for hydrodynamic shear and selective washout. Photogranulation as described here is a robust phenomenon with respect to inoculum characteristics and environmental parameters like carbon sources. A bioprocess using oxygenic photogranules is an attractive candidate for energy-positive wastewater treatment as it biologically couples CO<sub>2</sub> and O<sub>2</sub> fluxes. As a result, the external supply of oxygen may become obsolete and otherwise released CO<sub>2</sub> is fixed by photosynthesis for the production of an organic-rich biofeedstock as a renewable energy source.
My mental health (2008)

Alex Williams has worked hard to overcome her mental health problems, and with the support of a community psychiatric nurse she is now looking forward to making up for the lost years