gebhart/patrepeval huggingface dataset:
From the Cloud to Edge and IoT: a Smart Orchestration Architecture for Enabling Osmotic Computing (2018)

The latest technological and conceptual developments have destroyed the centralized Cloud Computing model, moving Cloud services in emerging ICT infrastructures such as Edge, Fog and Internet of Things (IoT) that are closer to end users. Specifically, current Cloud computing programming models and resource orchestration techniques are challenged by the recent evolution of the IoT phenomenon because smart devices are becoming more and more pervasive, powerful and inexpensive. Therefore, services need to be place near such devices. In this regard, the Osmotic Computing aims to provide a new computing paradigm based on the deployment and migration strategies related to the infrastructures and applications requirements across Cloud, Edge, Fog an IoT layers. In this scientific paper, we investigate the Smart Orchestration of a new software abstraction called MicroELement (MEL), that encapsulates resources, services and data necessary to run IoT applications. Several use cases are presented for describing the Artificial Intelligence processes that enables the MELs deployment.
Microchip capillary electrophoresis for frontal analysis of free bilirubin and study of its interaction with human serum albumin (2008)

To meet the need for bedside monitoring of free bilirubin for neonates under critical conditions, a microfluidic chip was fabricated and tested for its coupling with CE/frontal analysis (FA) to determine free bilirubin and study of its binding interaction with HSA, which regulated its concentration in plasma. The poly(methyl methacrylate) (PMMA) multichannel chip was fabricated by CO2 laser ablation and bonded with a fused-silica separation capillary for CE/FA separation with UV detection. The chip was designed to allow a complete assay of four electrophoretic runs using preconditioned channels to speed up the determination of free bilirubin and to deliver quick results for bedside monitoring. Under optimized conditions, the linear working range for free bilirubin was from 10 to 200 micromol with RSDs from 2.1 to 5.0% for n=3, and the LOD at 9 micromol for S/N=3. From a binding study between bilirubin and HSA under FA condition, the second binding constant for bilirubin-HSA was determined as 1.07x10(5) L/mol and the number of binding sites per HSA as 3.46. The results enabled the calculation of free bilirubin for jaundiced infants based on the clinically significant level of total bilirubin, producing a range of 118.3-119.4 micromol/L. The developed method is shown to meet the clinical requirement with additional margin of protection to detect the early rising level of free bilirubin prior to jaundice condition. The low-cost microchip CE/FA device is shown to produce quick results with high potential to deliver a suitable bed-side monitoring method for bilirubin management in neonates.
Designing porous scaffolds for tissue engineering (2005)

Biomaterials are either modified natural or synthetic materials, with an appropriate response in the host tissue, which find application in a wide spectrum of implants and prostheses used in reconstructive medicine. The subsequent integration and longevity of the implanted device depends on the effectiveness of the associated biological repair. Hence, there has been considerable interest in the development of novel, second generation, biomaterials, which are favourably bioactive in terms of promoting the desired cellular response in vivo. Such biomaterials in a porous form can also act as cellular scaffolds and allow in vitro, as well as in vivo incorporation of the appropriate tissue cells, with potential control of the sequence of cell attachment, proliferation and the production of extra-cellular matrix. Such generic tissue engineering depends critically on the porous architecture of the biomaterial scaffold so as to allow both the cellular ingress and vascularization required to create a living tissue. The particular requirements of tissue-engineering scaffolds with respect to macro- and micro-porosity, as well as chemistry, are reviewed.
Synthesis of Tumor-Inhibiting Complex Salts Containing the Aniontrans-Tetrachlorobis(indazole)ruthenate(III) and Crystal Structure of the Tetraphenylphosphonium Salt (1999)

Indazolium trans-tetrachlorobis(indazole)ruthenate(III) exhibits excellent results against different tumor models in vitro and in vivo. To improve the water solubility necessary for the introduction of this tumor-inhibiting compound into clinical trials, we synthesized the corresponding sodium salt in a two-step ion exchange via the tetramethylammonium salt. The sodium salt shows a 35-fold higher solubility in water relative to the indazolium salt. We also synthesized the n-butylammonium, n-octylammonium, and tetraphenylphosphonium salts, all of which showed improved solubility in organic solvents. The X-ray crystal structure of the latter could be solved, proving the trans configuration of the complex anion. In spite of the paramagnetic RuIII center an assignement of the coordinated indazole protons could be made with the help of a COSY experiment.
Drag reduction by polymer–polymer mixtures (1988)

Abstract An extensive study on the turbulent drag reduction caused by the various mixtures of polyacrylamide, purified guargum, xanthangum, and their graft copolymers has been conducted at low concentrations and Re = 14,000 using a turbulent flow rheometer. It has been found in most of the cases that the drag reduction caused by mixtures shows a positive deviation from the linearly additive straight line. This effect is more prominent when the drag reduction caused by both the constituents differ appreciably. In most of the cases, the drag reduction caused by the mixtures is higher than the DR caused by either of the constituent polymers; however, the drag reduction caused by the mixture is less than the sum of the drag reduction caused by both the constituents at their respective concentration in the mixture. It has also been noticed that there is no evidence of synergism in these mixtures at low concentrations.
Cooperative walk control of paraplegia patient and assistive system (2009)

This paper introduces a cooperative control algorithm that designs a stable biped walk satisfying a wearer's intention relating to his/her walk such as a timings to start and stop walking, walking speed and waking direction. Using this algorithm an exoskeletal walking support system could help a paraplegia patient walking comfortablly. At first, a pair of gloves with several DOFs is developed to convey a wearer's intention to the walking support system. He/she swings both his/her index fingers as to simulate foot motions of his/her walking. The amplitude and period of the swing corresponds to a step length and period of the walk, respectively. Pronation/supination of the wrist joint of his/her right arm corresponds to a walk direction. The cooperative control algorithm based on a cart-table model designs trajectories of each joint for stable walking pattern that satisfies the intention expressed by the wearer's hand motion and then the designed walking pattern is executed in realtime by the walking support system. As the first trial, a small humanoid robot ¿HRP-2m¿ is used for safety as a control target that will be a combination of a wearer and the walking support system in the final situation. Through some experiments we confirm that our proposed algorithm enables the humanoid robot to start and stop stable walk with variable step length in the desired walking direction according to operator's intentions.
Ginseng Nanoparticles: A Budding Tool for Cancer Treatment (2017)

Cancer is one of the most incurable diseases and is a major cause of death worldwide. It is estimated that the annual number of deaths due to cancer will be around 13.2 million by 2030 in all over the world Although chemotherapy is one of the mainstays for its treatment, the side effects as well as disadvantages, such as, normal cell cytotoxicity, chemoresistance and the ability to prevent the occurrence of cancers have been considered as important hitches. Thus, the complementary and alternative medicines with the utilization of the medicinal and functional food herbs could be an alternative method to combat the progression of cancers. In this juncture, oriental adaptogenic herbs (i.e., ginseng) could be promising candidates for the treatment of cancer as safe, complementary and alternative medicines as well as medicinal and functional food
Iterative LMMSE Channel Estimation and Decoding Based on Probabilistic Bias (2013)

Iterative channel estimation and decoding based on probabilistic bias is investigated. In order to control the occurrence probability of transmitted symbols, biased convolutional codes (CCs) are proposed. A biased CC is obtained by puncturing the parity bit of a conventional (unbiased) CC and by inserting a fixed bit at the punctured position when the state is contained in a certain subset of all possible states. A priori information about the imposed bias is utilized for the initial linear minimum mean-squared error (LMMSE) channel estimation. This paper focuses on biased turbo codes that are constructed as the parallel concatenation of two biased CCs with interleaving, and proposes an iterative LMMSE channel estimation and decoding scheme based on approximate belief propagation. The convergence property of the iterative LMMSE channel estimation and decoding scheme is analyzed via density evolution (DE). The DE analysis allows one to design the magnitude of the bias according to the coherence time, in terms of the decoding threshold. The proposed scheme is numerically shown to outperform conventional pilot-based schemes in the moderate signal-to-noise ratio (SNR) regime, at the expense of a performance degradation in the high SNR regime.
Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes (2007)

Recently, the ubiquitin proteasome system (UPS) has matured as a drug discovery arena, largely on the strength of the proven clinical activity of the proteasome inhibitor Velcade in multiple myeloma. Ubiquitin ligases tag cellular proteins, such as oncogenes and tumor suppressors, with ubiquitin. Once tagged, these proteins are degraded by the proteasome. The specificity of this degradation system for particular substrates lies with the E3 component of the ubiquitin ligase system (ubiquitin is transferred from an E1 enzyme to an E2 enzyme and finally, thanks to an E3 enzyme, directly to a specific substrate). The clinical effectiveness of Velcade (as it theoretically should inhibit the output of all ubiquitin ligases active in the cell simultaneously) suggests that modulating specific ubiquitin ligases could result in an even better therapeutic ratio. At present, the only ubiquitin ligase leads that have been reported inhibit the degradation of p53 by Mdm2, but these have not yet been developed into clinical therapeutics. In this review, we discuss the biological rationale, assays, genomics, proteomics and three-dimensional structures pertaining to key targets within the UPS (SCFSkp2 and APC/C) in order to assess their drug development potential. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com).
Polyurethanes: A class of modern versatile materials (1992)

The myriad applications of polyurethane coatings, foams, fibers, moldings, and elastomers demonstrate the versatility of urethane chemistry and the creativity of polymer scientists.
Genetic algorithms for simultaneous variable and sample selection in metabonomics (2008)

Abstract Motivation: Metabolic profiles derived from high resolution 1H-NMR data are complex, therefore statistical and machine learning approaches are vital for extracting useful information and biological insights. Focused modelling on targeted subsets of metabolites and samples can improve the predictive ability of models, and techniques such as genetic algorithms (GAs) have a proven utility in feature selection problems. The Consortium for Metabonomic Toxicology (COMET) obtained temporal NMR spectra of urine from rats treated with model toxins and stressors. Here, we develop a GA approach which simultaneously selects sets of samples and spectral regions from the COMET database to build robust, predictive classifiers of liver and kidney toxicity. Results: The results indicate that using simultaneous sample and variable selection improved performance by over 9% compared with either method alone. Simultaneous selection also halved computation time. Successful classifiers repeatedly selected particular variables indicating that this approach can aid defining biomarkers of toxicity. Novel visualizations of the results from multiple computations were developed to aid the interpretability of which samples and variables were frequently selected. This method provides an efficient way to determine the most discriminatory variables and samples for any post-genomic dataset. Availability: GA code available from http://www1.imperial.ac.uk/medicine/people/r.cavill/ Contact: r.cavill@imperial.ac.uk; t.ebbels@imperial.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
Correlation of growth properties and morphology with hormone responsiveness of mammary tumor cells in culture. (1981)

A cell line derived from the androgen-responsive Shionogi 115 mouse mammary carcinoma is being used to investigate the changes in cell function accompanying steroid removal from steroid-responsive breast tumor cells. Shiongi 115 mouse mammary carcinoma cells become androgen unresponsive after two weeks of culture in the absence of testosterone although androgen receptors are still present in the cytoplasm and nucleus. Androgen-responsive cells are fibroblastic in appearance, have a low serum requirement, and can proliferate in suspension culture. Unresponsive cells, however, show a flattened morphology, are serum sensitive, and are anchorage dependent. As the androgen receptor mechanism of the unresponsive cells is intact, loss of sensitivity may be caused by a postreceptor defect. To determine the nature of this defect, the temporal relationships of changes in hormone responsiveness, morphology, serum sensitivity, and growth properties have been examined over a period of seven weeks following removal of testosterone from Shionogi 115 mouse mammary carcinoma cell cultures. Responses to testosterone and anchorage independence are both lost over a period of one to two weeks while serum sensitivity increases more slowly during the same period. The most rapid and least reversible change is seen in morphology. It is suggested that hormone responsiveness is related to properties of the cytoskeleton and cell membrane which influence growth rates and multiple sensitivities of tumor cells.
Codes For Optical Recording (1985)

Codes for optical recordingJordan IsailovicCalifornia State University FullertonFullerton, California 92634AbstractOptical recording systems capable of information storage and retrieval, using a highly focused laser beamas the recording and playback source, have been developed to a point where products are introduced. Many vari-ties of archival write once, or nonalterable, optical storage media have been proposed and developed.Reversible or erasable optical storage media have been the subject of research since the earliest days of op-
Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners (1997)

The effects of dietary hot red pepper on energy metabolism at rest and during exercise were examined in long distance male runners 18-23 yr of age. A standardized meal was given on the evening prior to the experiment. The subjects had a meal (2720 kJ) with or without 10 g of hot red pepper for breakfast. During rest (2.5 h after meal) and exercise (pedaling for 1 h at 150 W, about 60% VO2max, using cycling ergometry), expired gasses and venous blood were collected. The meal with hot red pepper significantly elevated respiratory quotient and blood lactate levels at rest and during exercise. Oxygen consumption at rest was slightly but nonsignificantly higher in the hot red pepper meal at 30 min after the meal. Plasma epinephrine and norepinephrine levels were significantly higher in those who had only hot red pepper at 30 min after the meal. These results suggest that hot red pepper ingestion stimulates carbohydrate oxidation at rest and during exercise.
Docetaxel-associated myalgia&ndash;arthralgia syndrome in patients with breast cancer (2017)

Docetaxel-associated M-AS is an adverse effect causing incomplete drug treatment. Possible risk factors and effectiveness of treatments for the syndrome are presented.
C-WSL: Count-guided Weakly Supervised Localization (2017)

We introduce count-guided weakly supervised localization (C-WSL), an approach that uses per-class object count as a new form of supervision to improve weakly supervised localization (WSL). C-WSL uses a simple count-based region selection algorithm to select high-quality regions, each of which covers a single object instance during training, and improves existing WSL methods by training with the selected regions. To demonstrate the effectiveness of C-WSL, we integrate it into two WSL architectures and conduct extensive experiments on VOC2007 and VOC2012. Experimental results show that C-WSL leads to large improvements in WSL and that the proposed approach significantly outperforms the state-of-the-art methods. The results of annotation experiments on VOC2007 suggest that a modest extra time is needed to obtain per-class object counts compared to labeling only object categories in an image. Furthermore, we reduce the annotation time by more than $2\times$ and $38\times$ compared to center-click and bounding-box annotations.
Three Postulates to Help Identify the Cause of Alzheimer's Disease (2011)

Two centuries ago, the German bacteriologist Robert Koch proposed three postulates to support a causal relationship between a specific microbe and an infectious disease. Similarly, three postulates are formulated here to help evaluate hypothetical proposals attempting to explain the pathogenesis of Alzheimer's disease (AD). The first postulate requires that the cause of AD precedes the cognitive decline and neurodegenerative pathology that characterize AD. This rule identifies a primary event from a neuropathological effect generated by the disease process. The second postulate stipulates that interventions aimed at the proposed causal event should prevent or reverse the cognitive and neurodegenerative pathology associated with AD prior to disease onset. This postulate emphasizes prevention or reversal of emerging neurocognitive pathology considerably before AD onset. If the first and second postulate requirements are met, the third postulate follows that interventions targeting the causal event should significantly lower the incidence of AD. For a causal hypothesis to be considered "likely" pathogenic to AD, support from all three postulates is a requisite. The pragmatic potential of the three postulates was applied to seven proposals using evidence-based meta-analysis mainly from randomized controlled trials. Proposals included the amyloid-β, cell cycle, cholinergic, inflammatory, oxidative stress, tau, and vascular hypotheses. Clinical evidence derived from each proposal formed the basis for an inferential conclusion based on the level of confidence provided by the trial data. The three postulates may challenge or help validate a proposed cause-effect relationship to AD and serve as a useful model for designing more intelligent therapeutic interventions aimed at preventing AD.
Brain microvessel endothelial cells in tissue culture: A model for study of blood‐brain barrier permeability (1983)

Endothelial cells were prepared from bovine microvessels and grown in tissue culture. They contained factor VIII/von Willebrand antigen, the most specific market available for determination of the endothelial origin of cells in culture. The cultured cells formed complex tight junctions and contained few pinocytotic vessels. These properties are responsible for formation of the blood-brain barrier in vivo. When monolayers of the endothelial cells were exposed briefly to a calcium-free solution or treated with 1.6 M arabinose, distinctive morphological changes occurred in the intercellular contacts. In either case, a normal structure was reestablished following return to control medium. To assess the effect of these treatments on transcellular permeability, we measured the movement of sucrose labeled with carbon 14 across a monolayer of endothelial cells cultured on a collagen-coated nylon mesh. Removal of external calcium increased the rate of sucrose movement by 120%; the arabinose treatment increased transcellular flux by 40%.
Random-Forests-Based Network Intrusion Detection Systems (2008)

Prevention of security breaches completely using the existing security technologies is unrealistic. As a result, intrusion detection is an important component in network security. However, many current intrusion detection systems (IDSs) are rule-based systems, which have limitations to detect novel intrusions. Moreover, encoding rules is time-consuming and highly depends on the knowledge of known intrusions. Therefore, we propose new systematic frameworks that apply a data mining algorithm called random forests in misuse, anomaly, and hybrid-network-based IDSs. In misuse detection, patterns of intrusions are built automatically by the random forests algorithm over training data. After that, intrusions are detected by matching network activities against the patterns. In anomaly detection, novel intrusions are detected by the outlier detection mechanism of the random forests algorithm. After building the patterns of network services by the random forests algorithm, outliers related to the patterns are determined by the outlier detection algorithm. The hybrid detection system improves the detection performance by combining the advantages of the misuse and anomaly detection. We evaluate our approaches over the knowledge discovery and data mining 1999 (KDDpsila99) dataset. The experimental results demonstrate that the performance provided by the proposed misuse approach is better than the best KDDpsila99 result; compared to other reported unsupervised anomaly detection approaches, our anomaly detection approach achieves higher detection rate when the false positive rate is low; and the presented hybrid system can improve the overall performance of the aforementioned IDSs.
<title>Comparison of three methods for registration of abdominal/pelvic volume data sets from functional-anatomic scans</title> (2000)

The purpose of this work was to evaluate three volumetric registration methods in terms of technique, user-friendliness and time requirements. CT and SPECT data from 11 patients were interactively registered using: a 3D method involving only affine transformation; a mixed 3D - 2D non-affine (warping) method; and a 3D non-affine (warping) method. In the first method representative isosurfaces are generated from the anatomical images. Registration proceeds through translation, rotation, and scaling in all three space variables. Resulting isosurfaces are fused and quantitative measurements are possible. In the second method, the 3D volumes are rendered co-planar by performing an oblique projection. Corresponding landmark pairs are chosen on matching axial slice sets. A polynomial warp is then applied. This method has undergone extensive validation and was used to evaluate the results. The third method employs visualization tools. The data model allows images to be localized within two separate volumes. Landmarks are chosen on separate slices. Polynomial warping coefficients are generated and data points from one volume are moved to the corresponding new positions. The two landmark methods were the least time consuming (10 to 30 minutes from start to finish), but did demand a good knowledge of anatomy. The affine method was tedious and required a fair understanding of 3D geometry.