gebhart/patrepeval huggingface dataset:
[Review of] Roberto V. Vallangca. Pinoy: The First Wave (1979)

The importance of documenting “oral histories” in print has to be emphasized among all Pacific Asian American groups. Dr. Roberto Vallangca has done a superb job and should be rewarded greatly as an encouragement to others to document the personal histories of the “old timers” who immigrated to Hawaii and mainland United States before the war.
Pulmonary fungal infections in HIV-infected persons. (1993)

Fungal infections account for a large number of AIDS-index diagnoses and complicate the course of most patients with HIV disease. Infection with Cryptococcus neoformans is the most commonly encountered deep-seated fungal infection in AIDS and represents a major threat to HIV-infected people worldwide. Although most patients with cryptococcosis present with meningitis, pulmonary disease may occasionally dominate the clinical picture. Treatment of symptomatic pulmonary cryptococcosis remains amphotericin-B with or without 5-flucytosine. The toxicity and difficulty of administration of amphotericin-B has engendered interest in treatment alternatives with the new triazoles. As HIV infection has become more common in the American heartland, it has overlapped areas endemic for Histoplasma capsulatum, Coccidioides immitis, and Blastomycosis dermatitidis. Disease from these deep-seated fungal pathogens, whether from de novo exposure or reactivation, has protean manifestations. Common to all is a protracted, febrile, wasting illness, with or without respiratory symptoms. Treatment of choice for all these infections remains amphotericin-B, followed by lifelong-maintenance therapy with a triazole. In this article I review the microbiology, epidemiology, presentation, diagnosis, and treatment of AIDS-associated deep-seated fungal infections.
Detecting physical shock by a mobile phone and its applications in security and emergency (2009)

In this paper, we propose a method for detecting physical shock by a mobile phone and its applications in security and emergency scenarios. We use acceleration signal provided by accelerometers integrated in a mobile phone to detect shocks. The shock is identified by analysis of acceleration pattern using statistical signal processing methods. We propose to use such a shock detection application for increasing security of data access in a mobile phone, as well as identifying scenarios which user of mobile phone experiences risky emergency events.
Noble Gas Scintillation-Based Radiation Portal Monitors and Active Interrogation Systems (2006)

Noble gas scintillation detectors (NGSD) combine good scintillation properties such as high light yields and good energy resolution with cost-effective scalability to large detector masses. A unique capability of noble gas scintillators is outstanding discrimination between electron recoils (gamma-like events) and nuclear recoils (n-like events) down to low energy deposits of the order of tens of keVs. This capability allows the construction of fast neutron detectors with good timing capability. This work points out the potential advantages of using NGSDs for Homeland Security applications such as portal monitoring or active interrogation.
Purification of testicular transglutaminase by hydrophobic chromatography on phenyl-sepharose. (1992)

We developed a procedure for purification to homogeneity of cytosolic transglutaminase from bovine testes, by means of anion exchange, size exclusion and hydrophobic chromatography. The crucial step is chromatography on Phenyl sepharose, with specific elution by the inhibitor GTP. The enzyme displays the properties of type 2 transglutaminases.
Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2 (2010)

As a clinical medication for the treatment of hyperkinetic movement disorders, in conditions such as Huntington's disease, tetrabenazine (TBZ) has been always used in its racemic form. To establish whether or not its beneficial therapeutic actions are enantiospecific, a practical total synthetic route was developed to yield each enantiomeric form to allow their chemical and pharmacological characterization. We briefly summarize the total synthesis of TBZ and report a detailed procedure for resolution of TBZ into its enantiomers, (+)-TBZ and (-)-TBZ. This allowed determination of the optical rotation and absolute configurations of each TBZ enantiomer, based on X-ray crystallographic analysis, together with characterization of their inhibitory action at the vesicular monoamine transporter 2, where (+)-TBZ proved three-fold more active than (-)-TBZ.
Application of information technologies in building design decisions (1999)

Abstract Research and development of a new sophisticated software environment to support building design decisions are presented. This new software, the Building Design Advisor (BDA), is intended as a research tool, teaching aid and, eventually, as a practical professional tool to facilitate both strategic and detailed decision-making throughout the design process from the early schematic phases of building design through to the detailed specification of building components and systems. BDA supports the integrated, concurrent use of multiple simulation tools and databases, while allowing output to support multicriterion judgement. BDA's ultimate aims are to address the data needs of whole building life cycle analysis: design, construction, commissioning, operation, performance and demolition. Cette communication présente les travaux de recherche et de développement portant sur un nouvel environnement logiciel sophistiqué destine a faciliter la prise de décisions en matieèe de concepts de construction. Ce nouveau ligiciel, dénommé Building Design Advisor (BDA), est à la fois un outil de recherche, une aide pèdagogique et, finalement, un outil professionnel pratique qui facilite le processus décisionnel stratégique et détaillé tout au long de la procédure de conception, dès la première phase d'esquisse de conception d'un bâtiment jusqu'à la spécification détaillée des composants et des systèmes de ce bâtiment. Le BDA est compatible avec l'utilisation intégrée et simultanée de multiples outils de simulation et de bases de données et ses résultats sont compatibles avec des jugements multi-critères. Les objectifs ultimes du BDA sont d'étudier les besoins en données du processus d'analyse du cycle de vie complet d'un bâtiment: conception, construction, mise en service, exploitation/performances et démolition. Keywords: Design ProcessLife Cycle AnalysisBuilding PerformanceInformation ManagementDataModels
38-43 GHz quadrature VCO on 90 nm VLSI CMOS with feedback frequency tuning (2005)

A 40 GHz voltage controlled oscillator with quadrature phase outputs is presented in this paper. Feedback is applied for frequency tuning. Thus, no varactors are required. The fully integrated circuit is fabricated in 90 nm VLSI SOI CMOS technology. A large tuning range of 5 GHz, an output power per channel of -4.7 to -7.4 dBm and a phase noise of -80 to -87 dBc/Hz at 3 MHz offset were measured.
Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats (2019)

Behavioral modulatory effects of Xe are probably related to its generalized action on excitatory/inhibitory balance within the CNS. Our data suggest that subanesthetic short-term exposures to Xe have beneficial effect on several behavioral modalities and deserves further investigation.
Helical Ribbons for Molecular Electronics (2014)

We describe the design and synthesis of a new graphene ribbon architecture that consists of perylenediimide (PDI) subunits fused together by ethylene bridges. We created a prototype series of oligomers consisting of the dimer, trimer, and tetramer. The steric congestion at the fusion point between the PDI units creates helical junctions, and longer oligomers form helical ribbons. Thin films of these oligomers form the active layer in n-type field effect transistors. UV-vis spectroscopy reveals the emergence of an intense long-wavelength transition in the tetramer. From DFT calculations, we find that the HOMO-2 to LUMO transition is isoenergetic with the HOMO to LUMO transition in the tetramer. We probe these transitions directly using femtosecond transient absorption spectroscopy. The HOMO-2 to LUMO transition electronically connects the PDI subunits with the ethylene bridges, and its energy depends on the length of the oligomer.
Chrysin regulates NAD(P)H:quinoneoxidoreductase 1 and inflammatory mediators in rats exposed to smoking and thioacetamide (2018)

Tobacco smoking and hepatic damage causes oxidative stress in humans and underlay numerous chronic degenerative diseases. Heavy smoking yields toxins which induce necroinflammation and increase the severity of hepatic lesions. Accordingly, the main object of this study to investigate the effect of chrysin against thioacetamide (TAA)-induced liver injury in rats exposed to tobacco smoke in combination. The study was carried out by investigating the oxidative stress biomarkers (glutathione peroxidase, SOD, catalase, paroxynase-1 and NAD (P) H: quinoneoxidoreductase 1 activities), inflammatory markers (IL-6 and IL-8 levels and gene expressions of NF-κB and VEGF) as well as histopathogical examination. It was found a significant reduction in activities of antioxidant enzymes concomitant with cytokines elevation; (IL-6 and IL-8) in rats exposed to tobacco smoke in combination with (TAA) treatment compared with normal control. Additionally, the transcript levels of (NF-κB and VEGF) genes were significantly higher in the rats exposed to tobacco smoke in combination with (TAA) treatment compared with normal control. However, treatment with chrysin, the levels of these parameters were significantly decreased which demonstrates the ameliorative effect of chrysin against (TAA) induced liver injury in rats exposed to tobacco smoke in combination. Histological investigations revealed that chrysin gave more preventive effect against thioacetamide (TAA)-induced liver injury in rats exposed to tobacco smoke. In conclusion, chrysin modulated the damage induced by exposure to tobacco smoking and hepatic disease
Thrombin Activates NF‐κB through Thrombin Receptor and Results in Proliferation of Vascular Smooth Muscle Cells: Role of Thrombin in Atherosclerosis and Restenosis (1997)

We investigated the role of thrombin in the pathogenesis in atherosclerosis and restenosis. First we examined the effect of thrombin on cultured human vascular smooth muscle cells (VSMC). We showed that thrombin acts as a mitogen on VSMC through thrombin receptor. The expression of thrombin receptor was increased in the cell lines of VSMC established from directional coronary atherectomy (DCA). This is more pronounced in the cells from patients with restenosis after PTCA. Next we investigated the signaling pathway from thrombin/thrombin receptor. Thrombin activates thrombin receptor resulting in the exposing of the agonist peptide domain (thrombin receptor agonist peptide, TRAP). The signal from thrombin/thrombin receptor activated protein C kinase, tyrosine kinase, and MAP kinase and resulted in NF-kappa B activation. Furthermore, treatment of the cells with antisense p65 oligodeoxynucleotides of NF-kappa B inhibited the thrombin-stimulated growth of VSMC in vitro. These results suggest that thrombin may have a role in the pathogenesis of atherosclerosis and restenosis after PTCA through the thrombin receptor.
Controlled Delivery of DNA Origami on Patterned Surfaces (2009)

DNA origami structures are selectively immobilized onto lithographically patterned features with nanometer-scale precision, and these pre-positioned origami scaffolds are subsequently utilized as a template to deterministically deliver gold nanoparticles to specific locations within the origami.
Automated registration of coronary arterial trees from multiple phases in coronary CT angiography (cCTA) (2013)

We are developing an automated registration method for coronary arterial trees from multiple-phase cCTA to build a best-quality tree to facilitate detection of stenotic plaques. Cubic B-spline with fast localized optimization (CBSO) is designed to register the initially segmented left and right coronary arterial trees (LCA or RCA) separately in adjacent phase pairs where displacements are small. First, the corresponding trees in phase 1 and 2 are registered. The phase 3 tree is then registered to the combined tree. Similarly the trees in phases 4, 5, and 6 are registered. An affine transform with quadratic terms and nonlinear simplex optimization (AQSO) is designed to register the trees between phases with large displacements, namely, registering the combined tree from phases 1, 2, and 3 to that from phases 4, 5, and 6. Finally, CBSO is again applied to the AQSO registered volumes for final refinement. The costs determined by the distances between the vessel centerlines, bifurcation points and voxels of the trees are minimized to guide both CBSO and AQSO registration. The registration performance was evaluated on 22 LCA and 22 RCA trees on 22 CTA scans with 6 phases from 22 patients. The average distance between the centerlines of the registered trees was used as a registration quality index. The average distances for LCA and RCA registration for 6 phases and 22 patients were 1.49 and 1.43 pixels, respectively. This study demonstrates the feasibility of using automated method for registration of coronary arterial trees from multiple cCTA phases.
A Study of the Reaction of Hydroxide Ion with B<sub>20</sub>H<sub>18</sub><sup>-2</sup> (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Study of the Reaction of Hydroxide Ion with B20H18-2M. Frederick Hawthorne, Richard L. Philling, and Philip M. GarrettCite this: J. Am. Chem. Soc. 1965, 87, 21, 4740–4746Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/ja00949a013https://doi.org/10.1021/ja00949a013research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease. (2001)

Treatment with donepezil for 1 y appears to reduce the decline in rCBF, suggesting preservation of functional brain activity.
Towards the control of the reactivity in high temperature anionic polymerization of styrene: retarded anionic polymerization. 3– influence of triisobutylaluminum on the reactivity of polystyryllithium species (2000)

The addition of triisobutylaluminum to a lithiated-based anionic polymerization of styrene leads to the formation of aluminate complexes and provokes a drastic reduction of the styrene polymerizability in relation with the Al/Li ratio used. The reaction is first order in monomer and active species and is stopped for iBu3Al/PSLi > 1. From U.V. spectrometry, kinetic studies and viscometric measurements, it was possible to suggest the presence of various mixed complexes of different stoichiometries. The strong increase in the thermal stability of the new propagating species together with their much lower reactivity permits the controlled bulk polymerization of styrene at high temperature.
Circuit design for built-in current testing (2002)

Built-in current (BIC) testing has proven to be useful through a number of IC fabrication experiments. The experience gained from these experiments is summarized. From the information presented, a set of required rules is derived for the design of circuits employing BIC sensors. It is indicated that the system partition is the key design element affecting both the area overhead needed for BIC sensors and the testing clock rate. It is shown that special design rules must be observed during the design in order to avoid abnormally high I/sub ddq/ currents. It is concluded that by using BIC sensors it is possible to build small area overhead, self-testing ICs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Inactivation of the Intrinsic Activity of Pro-urokinase by Diisopropyl Fluorophosphate Is Reversible (1995)

Single chain urokinase-type plasminogen activator or pro-urokinase (pro-UK) has been reported to have a significant intrinsic amidolytic and plasminogen activator activity, estimated to be about 0.2-0.6% that of two-chain urokinase (UK). However, it has also been suggested that this reported activity is related entirely to trace UK contaminants generated during the analytic procedures. In an attempt to resolve this controversy, it was decided to measure the incorporation of diisopropyl fluorophosphate (DFP) by pro-UK and UK. Surprisingly, it was found that although > 98% of the apparent intrinsic activity of pro-UK was inhibited by 5 mM DFP, > 97% of this activity was recoverable after exhaustive dialysis of the preparation. This finding could not be explained by UK generation, which was excluded. Instead, the findings indicated that DFP inhibition of pro-UK, in contrast to UK and other serine proteases, was largely reversible. The reaction rate of the reversible inhibition was significantly slower than that of irreversible inhibition by DFP. When the hydrolysis of DFP (2 mM) during incubation (37 degrees C) with or without pro-UK (20 microM) was compared, a > 5-fold acceleration of DFP hydrolysis in the presence of pro-UK was found, whereas little loss of DFP occurred in the presence of UK (20 microM), consistent with 1:1 stoichiometry. This suggested that pro-UK acted as a slow DFPase in the reaction, a finding consistent with a reversible DFP-enzyme reaction. It was concluded that pro-UK has a distinct and measurable intrinsic catalytic activity, which is qualitatively unique and thereby distinguishable from that of UK as well as other serine proteases.
Interaction of β-Lactoglobulin with Resveratrol and its Biological Implications (2007)

Beta-lactoglobulin (beta-LG), the major whey protein in the milk of ruminants, has a high affinity for a wide range of compounds. Resveratrol (3,5,4'-trihydroxystilbene), a natural polyphenolic compound found in grapes and red wine, exhibits many physiological effects associated with health benefits. In this study, the interaction of resveratrol with beta-LG was investigated using circular dichroism, fluorescence and UV-vis absorbance. Self-association of resveratrol possibly occurs at high concentrations. Resveratrol interacts with beta-LG to form 1:1 complexes. Resveratrol is bound to the surface of the protein because beta-LG-bound polyphenol is in a weaker hydrophobic environment relative to 75% ethanol. The binding constant for the resveratrol-beta-LG interaction is between 10(4) and 10(6) M (-1), as determined by protein or polyphenol fluorescence. The beta-LG-resveratrol interaction may compete with self-association of both the polyphenol and the protein. It has no apparent influence on beta-LG secondary structure but partially disrupts tertiary structure. Complexing with beta-LG provides a slight increase in the photostability of resveratrol and a significant increase in its hydrosolubility.
Presence of Finger Extension and Shoulder Abduction Within 72 Hours After Stroke Predicts Functional Recovery (2010)

Based on 2 simple bedside tests, finger extension and shoulder abduction, functional recovery of the hemiplegic arm at 6 months can be predicted early in a hospital stroke unit within 72 hours after stroke onset.
Scaling Machine Learning for Target Prediction in Drug Discovery using Apache Spark (2015)

In the context of drug discovery, a key problem is the identification of candidate molecules that affect proteins associated with diseases. Inside Janssen Pharmaceutical, the Chemo genomics project aims to derive new candidates from existing experiments through a set of machine learning predictor programs, written in single-node C++. These programs take a long time to run and are inherently parallel, but do not use multiple nodes. We show how we reimplementation the pipeline using Apache Spark, which enabled us to lift the existing programs to a multi-node cluster without making changes to the predictors. We have benchmarked our Spark pipeline against the original, which shows almost linear speedup up to 8 nodes. In addition, our pipeline generates fewer intermediate files while allowing easier check pointing and monitoring.
Synthesis of polysulfonates for enhanced oil recovery by chemical flooding. Final report, 20 August 1979-14 August 1980 (1980)

Synthetic studies have been conducted on di- and trisulfonates of diphenylalkanes which may be the enhanced oil recovery (EOR) agents in commercial alkylbenzenesulfonates. Nine di- and trisulfonates of diphenylalkanes have been made and none has much EOR activity as the active fractions of commercial alkylbenzenesulfonates. Texas 2 (sulfonate of 5-(p-ethylphenyl) dodecane) has good EOR activity but Texas 2 has low solubility in brine. Structure modifications of Texas 2 led to compounds with less EOR activity than Texas 2 has. Removal of the para ethyl group from Texas gave a compound with no EOR activity as did the shortening of the longer alkyl group from 12 to 8 carbons. Replacing the ethyl group of Texas 2 with hydroxy and subsequent sulfonation yielded a sparingly brine soluble product with low EOR activity. Preliminary infrared and nuclear magnetic resonance studies of the methyl esters of EOR activity fractions of commercial alkylbenzenesulfonates (NBS and N5B) indicate that the active fractions are mixtures of p-alkylbenzenesulfonates.
4-Vinylproline (2018)

Enantiomerically pure 4-vinylproline (Vyp) was synthesized by a five-step approach from N-(Boc)iodo-alanine (2) featuring copper-catalyzed S<sub>N</sub>2' substitution of the corresponding zincate onto ( Z)-1,4-dichlorobut-2-ene to prepare methyl 2- N-(Boc)amino-4-(chloromethyl)hexenoate (3). Intra- and intermolecular displacement of the chloride provided respectively Vyp and methyl 2- N-(Boc)amino-4-(azidomethyl)hexenoate (7) suitable for the synthesis of constrained peptide analogs.
A recessed gate LDMOSFET for alleviating HCI effects (2016)

This paper proposes a partially recessed-gate structure which enables to enlarge HCI lifetime of an STI-based LDMOSFET without degrading important static performances such as breakdown voltage (BV) and specific on-resistance (Rsp). This improvement in HCI characteristic is observed regardless of channel types and voltage ratings. The recessed gate is formed in a field-plate region by dry-etching the STI with an extra mask step. Attentive width enlargement and precise depth control of the trench are found to be the keys to maximize the favorable effect on the HCI performance. Measurement data have confirmed that the proposed structure makes HCI lifetime improve by 1-2 orders of magnitude.
Turbulence Control in Wall Flows (1989)

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from experiments, field measurements, and large-scale simulations at multiple spatiotemporal scales. Machine learning (ML) offers a wealth of techniques to extract ...Read More