gebhart/patrepeval huggingface dataset:
A Metamaterial-inspired Approach to RF Energy Harvesting (2017)

We demonstrate an RF energy harvesting rectenna design based on a metamaterial perfect absorber (MPA). With the embedded Schottky diodes, the rectenna converts captured RF waves to DC power. The Fabry-Perot (FP) cavity resonance of the MPA greatly improves the amount of energy captured. Furthermore, the FP resonance exhibits a high Q-factor and significantly increases the voltage across the Schottky diodes, which improves the rectification efficiency, particularly at low power. This leads to factor of 16 improvement of RF-DC conversion efficiency at ambient intensity level.
Charge trapping in the reductive dissolution of colloidal suspensions of iron(III) oxides (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge trapping in the reductive dissolution of colloidal suspensions of iron(III) oxidesPaul Mulvaney, Ronald Cooper, Franz Grieser, and Dan MeiselCite this: Langmuir 1988, 4, 5, 1206–1211Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September 1988https://pubs.acs.org/doi/10.1021/la00083a028https://doi.org/10.1021/la00083a028research-articleACS PublicationsRequest reuse permissionsArticle Views679Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human chorionic gonadotropin and its subunits in hydatidiform mole and choriocarcinoma. (1977)

Serum human chorionic gonadotropin (hCG) was measured by a radioreceptorassay (RRA) and radioimmunoassay (RIA) and serum hCG-beta and hCG-alpha by RIA in 10 patients with intact mole, 3 patients with choriocarcinoma, and 4 patients with hydatidiform mole during treatment. hCG levels by RRA were higher in 5 of 10 molar pregnancies and ranged from 20,900 to 100,000 ng/ml and from 30,000 to 100,000 ng/ml by RIA. hCG levels by RRA and RIA paralleled one another closely during treatment of hydatidiform mole. hCG-alpha was higher than hCG by RRA and RIA and hCG-beta in molar pregnancies, in the uterine venous blood draining a uterine choriocarcinoma, and during chemotherapy of choriocarcinoma. In 2 of 3 choriocarcinoma patients who eventually developed cerebral metastases, hCG-alpha increased while hCG and hCG-beta were declining or negative. hCG-beta was usually lower than hCG or hCG-alpha in all the cases studied. These results demonstrate the production of free alpha and beta subunits in trophoblastic disease. Further, due to the biospecificity, simplicity, and rapidity, the RRA of hCG is a sueful diagnostic aid during treatment of trophoblastic neoplasia until the levels fall to within the sensitivity range of the assay. Finally, the RIA of hCG, hCG-beta, and hCG-alpha, which requires several days, should be performed until they become negative or fall within normal range.
Introduction (1950)

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Salience and Market-aware Skill Extraction for Job Targeting (2020)

At LinkedIn, we want to create economic opportunity for everyone in the global workforce. To make this happen, LinkedIn offers a reactive Job Search system, and a proactive Jobs You May Be Interested In (JYMBII) system to match the best candidates with their dream jobs. One of the most challenging tasks for developing these systems is to properly extract important skill entities from job postings and then target members with matched attributes. In this work, we show that the commonly used text-based \emph{salience and market-agnostic} skill extraction approach is sub-optimal because it only considers skill mention and ignores the salient level of a skill and its market dynamics, i.e., the market supply and demand influence on the importance of skills. To address the above drawbacks, we present \model, our deployed \emph{salience and market-aware} skill extraction system. The proposed \model ~shows promising results in improving the online performance of job recommendation (JYMBII) ($+1.92\%$ job apply) and skill suggestions for job posters ($-37\%$ suggestion rejection rate). Lastly, we present case studies to show interesting insights that contrast traditional skill recognition method and the proposed \model~from occupation, industry, country, and individual skill levels. Based on the above promising results, we deployed the \model ~online to extract job targeting skills for all $20$M job postings served at LinkedIn.
Nanostructured Carbonized Thin Films Produced by Plasma Immersion Ion Implantation of Block‐Copolymer Assemblies (2007)

Abstract We present a new approach for the fabrication of highly ordered carbonized nanostructured thin films involving the ion beam treatment of self‐assembled block copolymers precursors. 70 nm‐thick porous polystyrene‐ block ‐poly(4‐vinyl pyridine) assemblies were treated by 20 keV nitrogen ions at fluences of 10 15 –10 16 ions · cm −2 . The resulting 35 nm‐thick films are almost completely carbonized, as confirmed by FTIR and micro‐Raman spectra, and retain hexagonal nanomorphology. The films are mechanically robust, stable at high temperatures and well suited for applications as ultrafiltration membranes, quantum dot or single molecule supports, masks for nanolithography. The carbonization of the films due to ion beam exposure occurred at temperatures much lower than required for pyrolytic carbonization. magnified image
Regulation of Phospholipase D2:  Selective Inhibition of Mammalian Phospholipase D Isoenzymes by α- and β-Synucleins (1998)

Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified. Recombinantly expressed PLD2 has high basal activity and is insensitive to GTP-binding protein activators of PLD1 [Colley, W. C., et al. (1997) Curr. Biol. 7, 191-201]. To investigate the regulation of PLD2 we isolated PLD2, from mouse brain by immunoaffinity chromatography. The native and recombinant proteins have indistinguishable properties: PLD2 is potently activated by phosphoinositides with a vicinal 4,5-phosphate pair but is not stimulated by guanosine 5'-O-(3-thio triphosphate)-activated ADP-ribosylation factor-1, Rho family GTP-binding proteins, or protein kinases C-alpha, or -beta1. We used recombinant PLD2 in a reconstitution assay to search for regulators in cell and tissue extracts. Bovine brain contains a heat-stable protein factor that inhibits PLD2 activity in vitro. This factor was purified to homogeneity and identified as a mixture of alpha- and beta-synucleins by microsequencing and Western blotting. Recombinantly expressed alpha- and beta-synucleins inhibit PLD2 activity in vitro (K0.5 10 nM). Inhibition is not overcome by the protein or lipid activators of PLD1. Synucleins have been implicated in Parkinson's and Alzheimer's diseases. Our findings suggest that inhibition of PLD2 may be a function of synucleins. Modulation of PLD2 activity by synucleins may play a role in some aspects of the pathophysiologies that characterize these neurodegenerative diseases.
Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma (1990)

Cytogenetic studies may provide important clues to the molecular pathogenesis of thyroid neoplasia. Thus, the authors attempted cytogenetic studies on 12 thyroid carcinomas: seven papillary, three follicular, and two anaplastic. Successful cytogenetic results were obtained on all 12 tumors; nine (75%) had one or more chromosomally abnormal clones. Four of the papillary carcinomas had a simple clonal karyotype, and three had no apparent chromosome abnormality. All four abnormal papillary tumors contained an anomaly of a chromosome 10q arm. In one instance, an inv(10)(q11.2q21.2) was observed in a Grade 2 papillary carcinoma as the sole acquired abnormality. In another case, an inversion or insertion involving 10q21.2 was found in a Grade 1 papillary tumor. The karyotype of a third tumor, a Grade 1 papillary carcinoma, was 46,XX,der(5)t(5;10)(p15.3;q11),der(9)t(9;?)(q11;?). A fourth abnormal papillary carcinoma, a Grade 1 tumor, had a t(6;10)(q21;q26.1) as the sole abnormality. Each of the five follicular or anaplastic carcinomas had a complex clonal karyotype. The three follicular carcinomas contained an abnormality of 3p25-p21, along with several other chromosome abnormalities.
Multi-Stage Pedestrian Positioning Using Filtered WiFi Scanner Data in an Urban Road Environment (2020)

Since widespread applications of wireless sensors networks, low-speed traffic positioning based on the received signal strength indicator (RSSI) from personal devices with WiFi broadcasts has attracted considerable attention. This study presents a new range-based localization method for outdoor pedestrian positioning by using the combination of offline RSSI distance estimation and real-time continuous position fitting, which can achieve high-position accuracy in the urban road environment. At the offline stage, the piecewise polynomial regression model (PPRM) is proposed to formulate the Euclidean distance between the targets and WiFi scanners by replacing the common propagation model (PM). The online stage includes three procedures. Firstly, a constant velocity Kalman filter (CVKF) is developed to smooth the real-time RSSI time series and estimate the target-detector distance. Then, a least squares Taylor series expansion (LS-TSE) is developed to calculate the actual 2-dimensional coordinate with the replacement of existing trilateral localization. Thirdly, a trajectory-based technique of the unscented Kalman filter (UKF) is introduced to smooth estimated positioning points. In tests that used field scenarios from Guangzhou, China, the experiments demonstrate that the combined CVKF and PPRM can achieve the highly accurate distance estimator of <1.98 m error with the probability of 90% or larger, which outperforms the existing propagation model. In addition, the online method can achieve average positioning error of 1.67 m with the much better than classical methods.
A thiourea additive-based quadruple cation lead halide perovskite with an ultra-large grain size for efficient perovskite solar cells (2019)

Quadruple cation-based perovskite solar cells (PVSCs) have crossed the power conversion efficiency (PCE) of 25.2% because of their effective light harvesting ability. The perovskite materials and type of additives play a crucial role in improving the photovoltaic performance and stability. Therefore, here, we demonstrated a simple approach to reduce the grain boundaries and increase the grain size by adding thiourea (TU) as an additive in mixed halide (FAPbI3)0.85(MAPbBr3)0.15, triple cation Cs0.05[(FAPbI3)0.85(MAPbBr3)0.15]0.95 and quadruple Rb0.05{Cs0.05[(FAPbI3)0.85(MAPbBr3)0.15]0.95}0.95 cation perovskite absorbers. Our results indicate that the TU-added perovskite thin films have positive effects on the grain size, which improved up to 2.6 μm for the quadruple cation. Final optimization with the quadruple cation containing TU additive-based PVSC exhibited a 20.92% PCE, which is higher than additive-free PVSCs. Furthermore, the stability of the additive-modified PVSCs is much higher than that of bare films due to their ultra-large grain size with reduced grain boundaries. In addition, our thermal stress results exhibited that the additive-based PVSC devices display better thermal stability of more than ∼100 h at 60 °C without encapsulation.
Fast imaging of laboratory core floods using 3D compressed sensing RARE MRI (2016)

Three-dimensional (3D) imaging of the fluid distributions within the rock is essential to enable the unambiguous interpretation of core flooding data. Magnetic resonance imaging (MRI) has been widely used to image fluid saturation in rock cores; however, conventional acquisition strategies are typically too slow to capture the dynamic nature of the displacement processes that are of interest. Using Compressed Sensing (CS), it is possible to reconstruct a near-perfect image from significantly fewer measurements than was previously thought necessary, and this can result in a significant reduction in the image acquisition times. In the present study, a method using the Rapid Acquisition with Relaxation Enhancement (RARE) pulse sequence with CS to provide 3D images of the fluid saturation in rock core samples during laboratory core floods is demonstrated. An objective method using image quality metrics for the determination of the most suitable regularisation functional to be used in the CS reconstructions is reported. It is shown that for the present application, Total Variation outperforms the Haar and Daubechies3 wavelet families in terms of the agreement of their respective CS reconstructions with a fully-sampled reference image. Using the CS-RARE approach, 3D images of the fluid saturation in the rock core have been acquired in 16min. The CS-RARE technique has been applied to image the residual water saturation in the rock during a water-water displacement core flood. With a flow rate corresponding to an interstitial velocity of vi=1.89±0.03ftday(-1), 0.1 pore volumes were injected over the course of each image acquisition, a four-fold reduction when compared to a fully-sampled RARE acquisition. Finally, the 3D CS-RARE technique has been used to image the drainage of dodecane into the water-saturated rock in which the dynamics of the coalescence of discrete clusters of the non-wetting phase are clearly observed. The enhancement in the temporal resolution that has been achieved using the CS-RARE approach enables dynamic transport processes pertinent to laboratory core floods to be investigated in 3D on a time-scale and with a spatial resolution that, until now, has not been possible.
Effect of spaceflight on human stem cell hematopoiesis: suppression of erythropoiesis and myelopoiesis (1996)

Humans subjected to periods of microgravity develop anemia, thrombocytopenia, and abnormalities in red blood cell structure. The causes of these abnormalities are complex and unclear. The in vitro effects of spaceflight on hematopoietic cell proliferation and differentiation were investigated during the space shuttle missions STS-63 (Discovery) and STS-69 (Endeavour). CD34+ bone marrow progenitor cells were cultured in liquid suspension culture and on hematopoietic supportive stromal cells using hollow-fiber culture modules. One set of cultures was maintained at microgravity (flight cultures) for the last 8-10 days of culture and a second control was at full gravity (ground control). Over the 11- to 13-test-day period, ground control culture total cell number increased 41.0- to 65.5-fold but flight culture total cell number increased only 10.1- to 17.6-fold (57-84% decrease). Comparing ground control cultures and microgravity cultures, respectively, for progenitor cell content, myeloid progenitor cell numbers expanded 2.6- to 17.5-fold compared with 0.9- to 7.0-fold and erythroid progenitor cell numbers expanded 2.0- to 4.1-fold in ground control cultures but actually declined at microgravity (>83% reduction). Moreover, microgravity cultures demonstrated accelerated maturation/differentiation toward the macrophage lineage. These data indicate that spaceflight has a direct effect on hematopoietic progenitor cell proliferation and differentiation and that specific aspects of in vitro hematopoiesis, particularly erythropoiesis, involve gravity-sensitive components.
Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity (2016)

Increasing evidence demonstrates that berberine (BBR) is beneficial for obesity-associated non-alcoholic fatty liver disease (NAFLD). However, it remains to be elucidated how BBR improves aspects of NAFLD. Here we revealed an AMP-activated protein kinase (AMPK)-independent mechanism for BBR to suppress obesity-associated inflammation and improve hepatic steatosis. In C57BL/6J mice fed a high-fat diet (HFD), treatment with BBR decreased inflammation in both the liver and adipose tissue as indicated by reduction of the phosphorylation state of JNK1 and the mRNA levels of proinflammatory cytokines. BBR treatment also decreased hepatic steatosis, as well as the expression of acetyl-CoA carboxylase and fatty acid synthase. Interestingly, treatment with BBR did not significantly alter the phosphorylation state of AMPK in both the liver and adipose tissue of HFD-fed mice. Consistently, BBR treatment significantly decreased the phosphorylation state of JNK1 in both hepatoma H4IIE cells and mouse primary hepatocytes in both dose-dependent and time-dependent manners, which was independent of AMPK phosphorylation. BBR treatment also caused a decrease in palmitate-induced fat deposition in primary mouse hepatocytes. Taken together, these results suggest that BBR actions on improving aspects of NAFLD are largely attributable to BBR suppression of inflammation, which is independent of AMPK.
Flexible dosing schedules of panitumumab (ABX-EGF) in cancer patients (2005)

3089 Background Panitumumab is a fully human monoclonal antibody directed against the EGFr. In a Phase 1 trial in patients with colorectal, NSCL, renal, prostate, pancreatic, or esophageal cancer, the optimum weekly dose was determined to be 2.5 mg/kg (Roskos et al, ASCO 2002, Abstract 362). To allow for more convenient dosing, every 2 week (Q2W) or every 3 week (Q3W) dosing intervals were evaluated in the same Phase 1 trial. Methods: PK data from weekly doses in the range of 0.1 mg/kg to 5 mg/kg were fitted by a 2-compartment model with elimination of panitumumab occurring simultaneously via a Michaelis-Menten pathway and a first-order linear pathway. This model was used to simulate Q2W and Q3W regimens achieving serum trough panitumumab concentrations around 50 μg/mL, as was measured for the steady-state trough levels at the 2.5 mg/kg weekly dose. The model predicted that the trough concentration after three doses of 6 mg/kg Q2W or 9 mg/kg Q3W would be 53 and 47 μg/mL respectively. Patients were enrolled in 6 mg/kg Q2W (n=17) and 9 mg/kg (n=23) cohorts, with intensive PK sampling after the first and the third doses. Results Preliminary results indicate mean (SE) trough concentrations for 6 mg/kg Q2W and 9 mg/kg Q3W regimens after 3 doses were 49 (4) and 45 (8) μg/mL, respectively, consistent with simulations. The inter-individual variability in PK was low in both cohorts at CV ≤ 20%. After a single dose the mean (SD) Cmax was 147 (25) and 227 (45) μg/mL for the Q2W and the Q3W regimen respectively and the mean (SD) AUClast was 853 (173) and 1627 (293) μg*day/mL for the Q2W and the Q3W regimens respectively. Both regimens were generally well tolerated with a safety profile comparable to 2.5 mg/kg weekly. Conclusion Panitumumab administered at 6 mg/kg Q2W or 9 mg/kg Q3W resulted in exposure and tolerability profiles comparable to 2.5 mg/kg weekly, demonstrating the ability to dose panitumumab flexibly for enhanced patient convenience. Panitumumab exhibited predictable PK, with low inter- and intra-patient variability. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Abgenix, Amgen Abgenix, Amgen
Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne? (2010)

The present data suggest that activators of PPAR, in particular of the δ subset, might have beneficial effects on acne vulgaris by inhibiting the release of lipids in the context of sebocyte apoptosis.
Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function (2004)

Interleukin 7 (IL-7) is critical in maintaining thymic-dependent and thymic-independent pathways of T-cell homeostasis. T-cell receptor (TCR) rearrangement excision circles (TRECs) have been used as markers for recent thymic emigrants (RTEs) in assessing human thymic function. To study the thymic and peripheral effects of IL-7 on RTEs, we measured TREC content and peripheral naive T-cell subsets and turnover in IL-7-treated mice. Short-term administration of IL-7 into thymus-intact mice resulted in increased total TREC numbers, consistent with RTE accumulation. Decreases in TREC frequency were attributable to dilution secondary to increased cell turnover. Significantly, IL-7 administration into thymectomized mice resulted in patterns of decreased TREC frequency and increased total TREC number similar to those in IL-7-treated thymus-intact mice. Distinct patterns of naive cell and RTE distribution among peripheral immune organs and altered expression of CD11a were observed following IL-7 treatment in thymus-intact and thymectomized mice. These results demonstrate (1) that total TREC number and not TREC frequency accurately reflects quantitative changes in RTEs; (2) that short-term IL-7 administration results in preferential accumulations of RTEs among peripheral immune organs, accounting for the increase in TRECs in the total peripheral lymphoid pool; and (3) no evidence for regulation of thymic function by short-term IL-7 administration.
Worst-case manoeuvres for the roll-over and jackknife of articulated vehicles (1998)

The worst-case steering and braking manoeuvres for the roll-over and jackknife of a tractor/trailer vehicle are reported in this paper. The generation of worst-case manoeuvres is formulated as a one-player worst-case evaluation problem. Linear solutions are first solved by using classical optimal control theories. Nonlinear solutions are then obtained numerically. Sensitivity analysis based on the worst-case evaluation method is also performed to identify important variables for vehicle rollovers.
Dietary management reverses grooving and abnormal polarization of hair shafts in argininosuccinase deficiency (1991)

We have observed that the fragile hair of two untreated patients with argininosuccinic aciduria showed abnormal alternating zones of bright and dark banding by polarizing microscopy. Scanning electron microscopy documented discontinuous grooves with a 50 to 100 microns periodicity. Results of amino acid analysis of the hair were essentially normal. After the patients were treated with a low-protein, arginine-supplemented diet, the hair assumed a normal appearance. Five patients already treated with diet showed no hair abnormalities. The pathogenesis of the hair changes in unknown, but our findings suggest that products generated in the disease can adversely affect metabolically active tissue such as hair.