gebhart/patrepeval huggingface dataset:
The Yeast <i>ULP2</i> (<i>SMT4</i>) Gene Encodes a Novel Protease Specific for the Ubiquitin-Like Smt3 Protein (2000)

Yeast Smt3 and its vertebrate homolog SUMO-1 are ubiquitin-like proteins (Ubls) that are reversibly ligated to other proteins. Like SMT3, SMT4 was first isolated as a high-copy-number suppressor of a defective centromere-binding protein. We show here that SMT4 encodes an Smt3-deconjugating enzyme, Ulp2. In cells lacking Ulp2, specific Smt3-protein conjugates accumulate, and the conjugate pattern is distinct from that observed in a ulp1(ts) strain, which is defective for a distantly related Smt3-specific protease, Ulp1. The ulp2Delta mutant exhibits a pleiotropic phenotype that includes temperature-sensitive growth, abnormal cell morphology, decreased plasmid and chromosome stability, and a severe sporulation defect. The mutant is also hypersensitive to DNA-damaging agents, hydroxyurea, and benomyl. Although cell cycle checkpoint arrest in response to DNA damage, replication inhibition, or spindle defects occurs with normal kinetics, recovery from arrest is impaired. Surprisingly, either introduction of a ulp1(ts) mutation or overproduction of catalytically inactive Ulp1 can substantially overcome the ulp2Delta defects. Inactivation of Ulp2 also suppresses several ulp1(ts) defects, and the double mutant accumulates far fewer Smt3-protein conjugates than either single mutant. Our data suggest the existence of a feedback mechanism that limits Smt3-protein ligation when Smt3 deconjugation by both Ulp1 and Ulp2 is compromised, allowing a partial recovery of cell function.
Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis (2012)

Rheumatoid arthritis is a destructive arthropathy characterized by chronic synovial inflammation that imposes a substantial socioeconomic burden. Under the influence of the proinflammatory milieu, synovial fibroblasts (SFs), the main effector cells in disease pathogenesis, become activated and hyperplastic, releasing proinflammatory factors and tissue-remodeling enzymes. This study shows that activated arthritic SFs from human patients and animal models express significant quantities of autotaxin (ATX; ENPP2), a lysophospholipase D that catalyzes the conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA). ATX expression from SFs was induced by TNF, and LPA induced SF activation and effector functions in synergy with TNF. Conditional genetic ablation of ATX in mesenchymal cells, including SFs, resulted in disease attenuation in animal models of arthritis, establishing the ATX/LPA axis as a novel player in chronic inflammation and the pathogenesis of arthritis and a promising therapeutic target.
Effect of Fiber Length on Mechanical Properties of "Green" Composites Using a Starch-Based Resin and Short Bamboo Fibers (2004)

This paper describes a method to fabricate short bamboo fiber reinforced “green” composites (BFGC) and evaluate their mechanical properties. The composites were prepared by hot-pressing a mixture of starch-based resin and short bamboo fibers. Their tensile strength and flexural strength were characterized. The effects of fiber content and fiber length on the mechanical properties of BFGC were investigated in detail. Both tensile and flexural strengths of BFGC were strongly affected by fiber aspect ratio and fiber content. Bamboo fibers with a small aspect ratio of 20 do not act as reinforcement but as filler.
Robust Eye Region Discrimination and Eye Tracking to the Environmental Changes (2014)

안구 추적은 눈동자의 움직임을 감지하여 안구의 운동 상태나 시선의 위치를 추적하는 인간과 컴퓨터의 상호작용(HCI)분야이다. 안구 추적은 사용자의 시선 추적을 이용한 마케팅 분석이나 의도 인식 등에 적용되고 있으며 다양한 적용을 위한 많은 연구가 진행되고 있다. 안구 추적을 수행하는 방법 중에 영상처리를 이용한 안구 추적 방법이 사용자에게는 편리하지만 조명의 변화와 스케일 변화 그리고 회전이나 가려짐에는 추적의 어려움이 있다. 본 논문에서는 이미지 기반의 안구 추적시 발생되는 조명, 회전, 스케일 변화 등 환경변화에도 강인하게 안구 추적을 수행하기 위하여 두 단계의 추적 방법을 제안한다. 우선 Haar분류기를 이용하여 얼굴과 안구 영역을 추출하고, 추출된 안구 영역으로부터 CAMShift과 템플릿 매칭을 이용하여 강인하게 안구를 추적하는 두 단계의 안구 추적 방법을 제안하였다. 제안한 알고리즘은 조명 변화, 회전, 스케일 등 변화하는 환경 조건하에서 실험을 통하여 강인성을 증명하였다. The eye-tracking [ET] is used on the human computer interaction [HCI] analysing the movement status as well as finding the gaze direction of the eye by tracking pupil's movement on a human face. Nowadays, the ET is widely used not only in market analysis by taking advantage of pupil tracking, but also in grasping intention, and there have been lots of researches on the ET. Although the vision based ET is known as convenient in application point of view, however, not robust in changing environment such as illumination, geometrical rotation, occlusion and scale changes. This paper proposes two steps in the ET, at first, face and eye regions are discriminated by Haar classifier on the face, and then the pupils from the discriminated eye regions are tracked by CAMShift as well as Template matching. We proved the usefulness of the proposed algorithm by lots of real experiments in changing environment such as illumination as well as rotation and scale changes.
Long-term outcomes after reduced-intensity conditioning allogeneic stem cell transplantation for low-grade lymphoma: a survey by the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC) (2007)

Although associated with significant TRM, RIC allogeneic SCT in advanced chemosensitive disease leads to long-term survival.
An instrument for digital matrix photometry. (1981)

A new instrument was conceived and designed for quantitative measurement of chromophoric areas or colored spots such as are produced in (e.g.) thin-layer chromatography. The areas to be measured are subdivided grid-like into small subunits, and the absorbance of each of these is measured. The sum of absorbances for all subunits is directly proportional to the total amount of light-absorbing substances in a spot. The absorbances of the subunits are measured with a photodetector that contains hundreds of microscopically small photodiodes, arranged in a precise geometric array. The photodiode array is interfaced with a computer via an analog-to-digital converter for numerically integrating the individual signals from each photodiode. With this analytical system, quantitation of light-absorbing substance is accurate and precise for areas of different sizes, shapes, and internal irregularity.
Dendritic cell susceptibility to hepatitis C virus genotype 1 infection (2002)

In vitro infection of human monocyte-derived dendritic cells was carried out to study their susceptibility to hepatitis C virus (HCV) infection. Immature dendritic cells and mature dendritic cells were incubated overnight at 37 degrees C with HCV-positive (genotype 1) serum samples; the presence of the viral genome associated with the production of its replicative intermediate was used as evidence of infection. In immature dendritic cells, HCV RNA was detectable from days 1-10 post-infection (p.i.), and de novo synthesis of negative-strand HCV RNA could be demonstrated by a strand-specific rTth reverse transcription-polymerase chain reaction at day 2. In mature dendritic cells, the positive-strand form was detectable from days 1-5 p.i., while the negative-strand HCV RNA appeared at days 1 and 2 p.i. Quasispecies present in the inoculum and 6 days p.i. were analyzed by sequencing hypervariable region 1 of the E2 protein. Only two of seven HVR variants present in the inoculum were found in HCV-infected immature dendritic cells. Another two HVR variants not found in the inoculum were recovered from infected immature dendritic cells, suggesting serum minor variants selection or virus evolution during in vitro replication. Analysis by single-strand conformation polymorphism assay of 5' untranslated region of HCV sequences showed that the patterns obtained from the inoculum and infected immature dendritic cells and mature dendritic cells differed slightly. These findings indicate that both immature dendritic cells and mature dendritic cells are susceptible to HCV genotype 1 infection, supporting at least HCV RNA replication. This model should be a valuable tool for the study of modulation of dendritic cell functions in HCV infection.
Synthesis of 3-tert-butylpyridine. (1978)

3-tert-Butylpyridine (11) has been synthesized from neopentyl alcohol in 16% overall yield through a five-step sequence. Among the steps involved are the cycloaddition of α-tert-butylacrolein (9) to butyl vinyl ether and conversion of the resulting dihydropyran derivative (10) into the pyridine base (11).
Energy-Autonomous Picocell Remote Antenna Unit for Radio-Over-Fiber System Using the Multiservices Concept (2012)

The study reported in this letter deals with the extension of the multiservices concept to radio-over-fiber systems with energy-autonomous picocell remote antenna units. Continuous-power, radio-frequency, and digital signals have been combined in a single multimode fiber for the first time. The results clearly demonstrate no impairment of the optically powered remote antenna unit compared to an electrically powered version. The proposed system complies with the classical baseband Ethernet high-data-rate network (10 GbE bit error rate 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> ). The measured error vector magnitude for the radio-frequency (IEEE802.11g) signal transmission through the designed system stays around 2%, including both the optical transmission over 100-m OM3 multimode fiber and a wireless coverage of 5 m.
Evaluation of Lewis Acidity of “Naked” Lithium Ion through Diels-Alder Reaction Catalyzed by Lithium TFPB in Nonpolar Organic Solvents (2000)

Abstract The Diels-Alder reaction of cyclopentadiene with methyl vinyl ketone was remarkably promoted by anhydrous LiTFPB as a Lewis acid catalyst both in dichloromethane and in toluene. Experimental and computational investigations revealed the effects of solvent, hydrating water molecules, and counter anions on the Lewis acidity of the “naked” lithium ion.
The Performance and Scalability of Parallel Systems (1994)

In this thesis wedevelopananalytical performance model for parallel computer systems. This model is builtonthree abstract performance elements; loading intensity, contention, anddelay.These elements correspondto performance measures that are theoutcome of features of both software andhardware components of a computing system. The pro#le of these components can in turn be derived from an analysis of the performance-related behaviour of theindividual processes that constitute a complete system.
Big Data Analytics Framework for System Health Monitoring (2015)

In this paper, we present our Machine Learning (ML) based big data analytics framework that we tested to improve the quality and performance of Auxiliary Power Units (APU) health monitoring services. We are motivated to develop and apply practical and useful big data analytics technologies for industrial applications in aerospace and aviation. Key contributions of our work include the development and use of our ML algorithms that have been tested and used to analyze multiple data sources and to provide useful insights and increase the ability to predict (1) APU wear from 39%to 56% and (2) APU shutdown events from 19% to 60%. Such system health monitoring can be integrated with the widely used condition based maintenance (CBM) services. Users can use this cloud based analytic toolset and access the big data through any devices (PCs, Tablets, smart phones) anytime and anywhere.
Configurable hardware implementation of triple-DES encryption algorithm for wireless local area network (2002)

This paper presents three implementations of triple data encryption standard (3DES) algorithm on a configurable platform. Implementations are aimed at the medium access control (MAC) protocol of a multimedia-capable wireless local area network (WLAN). For this reason, very strict timing constraints as well as demands for area-efficiency are present. The MAC processing is handled by a digital signal processor (DSP) and a Xilinx Virtex field programmable gate array (FPGA) chip. The latter one is also used for the presented encryption implementations. As a result of the study, 3DES implementations with small area and reasonable throughput and, on the contrary, with large area and very high throughput are realized. Even though 3DES turns out to be quite large and resource-demanding, the implementations still leave enough chip area for the other MAC functions. Consequently, the set requirements are met and the cipher can be integrated into the system.
Capillary zone electrophoresis with indirect photometric detection in the visible range (1994)

Sensitivity and applicability of commonly used indirect photometric detection in the UV region can be adversely affected by the absorption of the UV light by detected solutes and/or by matrix constituents migrating with them. If the visible light is exploited instead of the UV light, both these disadvantages may be for the most part eliminated, and, moreover, the indirect photometric detection will extend its versatility and sensitivity. Prospects as well as main problems of the approach were tested using inorganic ions as analytes. If organic dyes with a molar light absorption coefficient of the order of 10(6) mol-1 L m-1 was selected as the light-absorbing constituents of the background electrolyte, detection sensitivity comparable with the best reported results was reached for anions; for cations, the detection limit was even lower by two orders of magnitude.
Emission and Performance of a Lean-Premixed Gas Fuel Injection System for Aeroderivative Gas Turbine Engines (1996)

A dry-low-NOx, high-airflow-capacity fuel injection system for a lean-premixed combustor has been developed for a moderate pressure ratio (20:1) aeroderivative gas turbine engine. Engine requirements for combustor pressure drop, emissions, and operability have been met. Combustion performance was evaluated at high power conditions in a high-pressure, single-nozzle test facility, which operates at full base-load conditions. Single digit NOx levels and high combustion efficiency were achieved. A wide operability range with no signs of flashback, autoignition, or thermal problems was demonstrated. NOx sensitivities to pressure and residence time were found to be small at flame temperatures below 1850 K (2870°F). Above 1850 K some NOx sensitivity to pressure and residence time was observed and was associated with the increased role of the thermal NOx production mechanism at elevated flame temperatures.
Identification of latent tuberculosis infection-related microRNAs in human U937 macrophages expressing Mycobacterium tuberculosis Hsp16.3 (2014)

The results suggest that miRNA expression may play a considerable role in the pathogenesis of LTBI, and this would increase our understanding of the molecular basis of Hsp16.3-facilitated Mtb survival in macrophages.
An improved digital polymerase chain reaction protocol to capture low‐copy <i><scp>KRAS</scp></i> mutations in plasma cell‐free <scp>DNA</scp> by resolving ‘subsampling’ issues (2017)

Genetic alterations responsible for the initiation of cancer may serve as immediate biomarkers for early diagnosis. Plasma levels of cell-free DNA (cfDNA) in patients with cancer are higher than those in healthy individuals; however, the major technical challenge for the widespread implementation of cfDNA genotyping as a diagnostic tool is the insufficient sensitivity and specificity of detecting early-stage tumors that shed low amounts of cfDNA. To establish a protocol for ultrasensitive droplet digital polymerase chain reaction (ddPCR) for quantification of low-frequency alleles within a limited cfDNA pool, two-step multiplex ddPCR targeting eight clinically relevant mutant KRAS variants was examined. Plasma samples from patients with colorectal (n = 10) and pancreatic cancer (n = 9) were evaluated, and cfDNA from healthy volunteers (n = 50) was utilized to calculate reference intervals. Limited cfDNA yields in patients with resectable colorectal and pancreatic cancers did not meet the requirement for efficient capture and quantification of rate mutant alleles by ddPCR. Eight preamplification cycles followed by a second-run ddPCR were sufficient to obtain approximately 5000-10 000 amplified copies per ng of cfDNA, resolving the subsampling issue. Furthermore, the signal-to-noise ratio for rare mutant alleles against the extensive background presented by the wild-type allele was significantly enhanced. The cutoff limit of reference intervals for mutant KRAS was determined to be ~ 0.09% based on samples from healthy individuals. The modification introduced in the ddPCR protocol facilitated the quantification of low-copy alleles carrying driver mutations, such as oncogenic KRAS, in localized and early-stage cancers using small blood volumes, thus offering a minimally invasive modality for timely diagnosis.
Recovery of zinc from pickling baths with amberlite LA‐2. Influence of modifier on the extraction equilibrium (1994)

Abstract The extraction of zinc chloride by Amberlite LA‐2, a long chain secondary alkylamine, dissolved in Shellsol K, a naphthenic solvent, has been studied at room temperature. Isodecanol was used as modifier. The aqueous phases were chloride solutions of Zn(II) and Fe(II) in the concentration range commonly encountered in pickling baths, viz. about 1 and 1.5 mol/l, respectively. The ionic strength was kept constant at 4 mol/l in all experiments. Measurement of the distribution equilibrium of zinc chloride was carried out over wide concentration ranges of amine, zinc chloride, free chloride and isodecanol. It was assumed that the zinc chloride was extracted according to the following reaction On the basis of this reaction, an easy to use model was developed to describe the extraction behaviour of Zn in typical pickling baths. Prediction and optimization of a solvent extraction plant performance under changing industrial feed conditions is then possible. This model takes account of the influence of isodecanol used as modifier.
The Effects of Cortisone and Anabolic Steroids on the Tensile Strength of Healing Wounds (1969)

From the Department of Surgery, University of California School of Medicine and San Francisco General Hospital *Training Fellow in Biochemistry, National Science Foundation. **Reprint requests: U. C. Surgical Service, 3rd Floor Solarium, San Francisco General Hospital, 22nd & Potrero, San Francisco, California 99410.
Spectroscopy of Dy^3+ in Ge–Ga–S glass and its suitability for 13-μm fiber-optical amplifier applications (1994)

Absorption and emission spectra, along with lifetime measurements, of Dy(3+) in Ge-Ga-S glasses are reported. Fluorescence is observed at 1.3, 1.8, and 2.9 microm. A Judd-Ofelt analysis is performed to determine branching ratios and quantum efficiencies. The hypersensitive transition (6)F(11/2) ? (6)H(15/2) at 1.3 microm has a quantum efficiency of 17%. Its suitability for an optical amplifier at 1.3 microm depends on the excited-state absorption from the (6)H(11/2) and (6)H(13/2) states, which has not yet been measured.
Identification of acetic acid bacteria isolated from fruits collected in Thailand (2004)

Since Thailand is located in a tropical area, we have expected that many species of acetic acid bacteria will be found in this country. This study aims at the isolation and identification of acetic acid bacteria from fruits and other source materials collected in Thailand.
ChemInform Abstract: ASYMMETRIC EPOXIDATION OF HYDROCARBON OLEFINS BY TERT‐BUTYL HYDROPEROXIDE WITH MOLYBDENUM(VI) CATALYSTS IN THE PRESENCE OF OPTICALLY ACTIVE DIOLS. APPLICATION TO THE ASYMMETRIC SYNTHESIS OF (3S)‐2,3‐OXIDOSQUALENE (1979)

Abstract Die Epoxidierung von 1‐Methyl‐cyclohexen (I) zum Epoxid (II) mit tert.‐Butylhydroperoxid unter Zusatz von Molybdän(VI)‐Katalysatoren wird untersucht.
Medical students’ perceptions of video-linked lectures and video-streaming (2010)

Video-linked lectures allow healthcare students across multiple sites, and between university and hospital bases, to come together for the purposes of shared teaching. Recording and streaming video-linked lectures allows students to view them at a later date and provides an additional resource to support student learning. As part of a UK Higher Education Academy-funded Pathfinder project, this study explored medical students’ perceptions of video-linked lectures and video-streaming, and their impact on learning. The methodology involved semi-structured interviews with 20 undergraduate medical students across four sites and five year groups. Several key themes emerged from the analysis. Students generally preferred live lectures at the home site and saw interaction between sites as a major challenge. Students reported that their attendance at live lectures was not affected by the availability of streamed lectures and tended to be influenced more by the topic and speaker than the technical arrangements. These findings will inform other educators interested in employing similar video technologies in their teaching.Keywords: video-linked lecture; video-streaming; student perceptions; decisionmaking; cross-campus teachingDOI: 10.1080/09687761003657622
Studies on microbial chromate reduction by <i>Pseudomonas</i> Sp. In aerobic continuous suspended growth cultures (1994)

Reduction of hexavalent chromium was studied in three bench-scale continuous stirred tank reactors. The inoculum was a culture of Pseudomonas sp., capable of giving 83% to 87% chromate reduction in 72-h batch assays with 60 mg Cr(VI) L(-1) in synthetic medium. The continuous culture studies were conducted for about 100 days using synthetic feed containing different levels of chromate (5 to 124 mg L(-1)) at 28 degrees to 30 degrees C and pH 6.8. The feed rate was varied over the range 0.5 to 1 L d(-1) to obtain hydraulic retention time of 36 to 72 h. Chromate reduction efficiency was 81% to 91% and 100% for influent Cr(VI) concentrations of 15 to 124 and 5 mg L(-1), respectively, with a hydraulic retention time of 72 h. (c) 1994 John Wiley & Sons, Inc.
Drift detection and monitoring in non-stationary environments (2014)

Detecting changes in data streams is an important area of research in many applications. The challenging issue is to know how to monitor, update and diagnose these changes so that the accuracy of the learner will be improved whatever the nature of the encountered drifts. In this paper a new error distance based approach for drift detection and monitoring, namely EDIST, is proposed. In EDIST, a difference in error distance distributions of two data-windows is monitored through a statistical hypothesis test. The proposed approach is tested using synthetic data and well known real world data sets. Encouraging results were found comparing to others similar approaches. EDIST has reached the best accuracies in most cases and shown more robustness to noise and false alarms.
Q-Fan Demonstrator Engine (1975)

Design criteria as well as a general description are provided for the first full-scale variable pitch fan engine tested in this country. The test facility for this 6700 Ib thrust engine is defined, and a summary of the test program is presented. Aerodynamic, acoustic, and structural data from the initial test phase are discussed. A ground adjustable mechanism was used to set fan blade angle for the first series of tests. A second test phase was conducted with a dynamic pitch change capability incorporated in the engine; the significance of reverse transient results are examined.