gebhart/patrepeval huggingface dataset:
Safety of Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Animals and Humans (2011)

Adipose tissue-derived mesenchymal stem cells (AdMSCs) represent an attractive and ethical cell source for stem cell therapy. With the recent demonstration of MSC homing properties, intravenous applications of MSCs to cell-damaged diseases have increased. In the present study, the toxicity and tumorigenicity of human AdMSCs (hAdMSCs) were investigated for clinical application. Culture-expanded hAdMSCs showed the typical appearance, immunophenotype, and differentiation capacity of MSCs, and were genetically stable at least 12 passages in culture. Cells suspended in physiological saline maintained their MSC properties in a cold storage condition for at least 3 days. To test the toxicity of hAdMSCs, different doses of hAdMSCs were injected intravenously into immunodeficient mice, and the mice were observed for 13 weeks. Even at the highest cell dose (2.5×10(8) cells/kg body weight), the SCID mice were viable and had no side effects. A tumorigenicity test was performed in Balb/c-nu nude mice for 26 weeks. Even at the highest cell dose (2×10(8) MSCs/kg), no evidence of tumor development was found. In a human clinical trial, 8 male patients who had suffered a spinal cord injury >12 months previous were intravenously administered autologous hAdMSCs (4×10(8) cells) one time. None of the patients developed any serious adverse events related to hAdMSC transplantation during the 3-month follow-up. In conclusion, the systemic transplantation of hAdMSCs appears to be safe and does not induce tumor development.
Classifying and Aggregating Context Attributes for Business Service Requests - No 'One-Size-Fits-All' (2014)

When building decision-making models from disparate observations, there are no set rules to guide the designer on how to organize available information, how to classify vital aspects, how to emphasize important ones in the aggregation process, and how to deal with conflict and uncertainty in the aggregation procedures. This paper draws on the experience of structuring a business and risk model that evaluates service requests, which requires not only dynamic context-based decisions, but also situational and behavioral perspectives, with high uncertainty and wide variations of attribute styles. This study focuses on design issues that affect classification and aggregation options, such as corroboration, primacy and discord, and provides examples of classified key-factors that demonstrate the design issues. The paper suggests procedures and algorithms to fit the design, but shows that there is no universal method - there is no 'one-size-fits-all'.
Genome Sequence of Strain IMCC3088, a Proteorhodopsin-Containing Marine Bacterium Belonging to the OM60/NOR5 Clade (2011)

Strain IMCC3088, cultivated from the Yellow Sea, is a novel isolate belonging to the OM60/NOR5 clade and is closely related to clone OM241, Congregibacter litoralis, and strain HTCC2080. Here, the genome sequence of strain IMCC3088 is presented, showing the absence of photosynthetic gene clusters and the presence of proteorhodopsin.
Aquaporin Deletion in Mice Reduces Corneal Water Permeability and Delays Restoration of Transparency after Swelling (2002)

Two aquaporin (AQP)-type water channels are expressed in mammalian cornea, AQP1 in endothelial cells and AQP5 in epithelial cells. To test whether these aquaporins are involved in corneal fluid transport and transparency, we compared corneal thickness, water permeability, and response to experimental swelling in wild type mice and transgenic null mice lacking AQP1 and AQP5. Corneal thickness in fixed sections was remarkably reduced in AQP1 null mice and increased in AQP5 null mice. By z-scanning confocal microscopy, corneal thickness in vivo was (in microm, mean +/- S.E., n = 5 mice) 123 +/- 1 (wild type), 101 +/- 2 (AQP1 null), and 144 +/- 2 (AQP5 null). After exposure of the external corneal surface to hypotonic saline (100 mosm), the rate of corneal swelling (5.0 +/- 0.3 microm/min, wild type) was reduced by AQP5 deletion (2.7 +/- 0.1 microm/min). After exposure of the endothelial surface to hypotonic saline by anterior chamber perfusion, the rate of corneal swelling (7.1 +/- 1.0 microm/min, wild type) was reduced by AQP1 deletion (1.6 +/- 0.4 microm/min). Base-line corneal transparency was not impaired by AQP1 or AQP5 deletion. However, the recovery of corneal transparency and thickness after hypotonic swelling (10-min exposure of corneal surface to hypotonic saline) was remarkably delayed in AQP1 null mice with approximately 75% recovery at 7 min in wild type mice compared with 5% recovery in AQP1 null mice. Our data indicate that AQP1 and AQP5 provide the principal routes for corneal water transport across the endothelial and epithelial barriers, respectively. The impaired recovery of corneal transparency in AQP1 null mice provides evidence for the involvement of AQP1 in active extrusion of fluid from the corneal stroma across the corneal endothelium. The up-regulation of AQP1 expression and/or function in corneal endothelium may reduce corneal swelling and opacification following injury.
Stereoscopic 3D View Synthesis From Unsynchronized Multi-View Video (2011)

Publication in the conference proceedings of EUSIPCO, Barcelona, Spain, 2011
Full Factorial Design in Formulation of Lamotrigine Suspension using Locust Bean Gum (2013)

Lamotrigine, a weakly basic, anticonvulsant drug have high permeability but poor solubility belonging to BCS Class II. The aim of this work was to formulate suspension in order to improve the bioavailability and patient compliance. In the present investigation, a perfect suspension was made using Locust bean gum, sodium alginate as viscosity enhancers and sodium citrate as anti-flocculant. Using 2 level 3 factor full factorial design, amount of ingredients were selected as independent variables while viscosity and sedimentation volume as response or dependent variables. The responses of data were recorded and analyzed for ANOVA, the individual parameters were evaluated by polynomial equation for each response generated using multiple linear regression analysis. The relationship between dependent and independent variables was further elucidated using contour plots finally optimized for desired response. From the results the eight formulations were made by factorial design, later optimized batch was prepared after desirability analysis and validated the obtained value with predicted showing good reliability of the design, highest r 2 and lowest sum of squares of residual was observed for the responses. Thus the prepared suspension showed high sedimentation volume, high redispersibility and optimum viscosity following non-Newtonian type behavior.
Noise elimination processing of seismic signals based on wavelet transform (2009)

Priority should be put on improving the signal-to-noise ratio in the digital processing of the seismic signals. The writers studied the application of some commonly used wavelet noise elimination methods to remove the random noise,and respectively analyzed their characteristics and improved the calculating methods. The simulation results of MATLAB show that the noise elimination processing of seismic signals based on wavelet transform is apparently better than the traditional Fourier method.
Laser-driven fusion etching process (2023)

The surfaces of solid ionic substrates are etched by a radiation-driven chemical reaction. The process involves exposing an ionic substrate coated with a layer of a reactant material on its surface to radiation, e.g. a laser, to induce localized melting of the substrate which results in the occurrance of a fusion reaction between the substrate and coating material. The resultant reaction product and excess reactant salt are then removed from the surface of the substrate with a solvent which is relatively inert towards the substrate. The laser-driven chemical etching process is especially suitable for etching ionic salt substrates, e.g., a solid inorganic salt such as LiNbO.sub.3, such as used in electro-optical/acousto-optic devices. It is also suitable for applications wherein the etching process is required to produce an etched ionic substrate having a smooth surface morphology or when a very rapid etching rate is desired.
Cameras and display systems (1995)

We first discuss the position of cameras and displays in digital television systems. It is difficult to realize these devices in digital form so cameras and displays will remain analog for some time, even after television signal processing is implemented digitally. Nevertheless, the importance of camera and display in television systems will not diminish. These devices will always be key elements in the human interface. Second, we describe the current state of the art and future trends in camera and display technology. In addition to providing an overview of the charge coupled device (CCD), we discuss the digital technologies used in a CCD camera. We also provide an overview of currently available displays-CRT's, flat panel displays, projection displays, and head-mounted displays (HMD's)-and discuss future possible lines of research. Finally, we discuss camera and display technology as applied to digital television systems, including the use of these devices in a multimedia environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Twincore erbium-doped fibre amplifier with passive spectral gain equalisation (1993)

Automatic spectral gain equalisation is demonstrated using controlled spatial hole-burning in an erbium-doped twincore fibre. Gain equalisation rates up to 0.11 dB difference between input signal levels are demonstrated and should increase the useful bandwidth of cascaded amplifiers.
Efficient clustering and visibility calculation for global illumination (2003)

Using a radiosity method to estimate light inter-reflections within large scenes still remains a difficult task. The two main reasons are: (i) the computations entailed by the radiosity method are time consuming and (ii) the large amount of memory needed is very large. In this paper, we address this problem by proposing a new clustering technique as well as a new method of visibility computation for complex indoor scenes. Our clustering algorithm groups polygons that are close to each other in each room (or corridor) of the building. It relies on a classification method of k-mean type and allows the use of several kinds of distance functions. For each group of polygons (or cluster), we estimate the set of potentially visible clusters with the help of openings such as doors or windows. This computation results in a graph in which the nodes correspond to clusters and the edges express visibility relationships between the corresponding clusters. We use this graph for computing radiosity in complex buildings while reducing both the amount of memory needed and the computing time. Our global illumination method is a MWRA (multi-wavelet radiosity algorithm). Unlike cluster-based radiosity methods, our MWRA does not approximate (but computes accurately) the light energy impinging or leaving a cluster after multiple reflections. We provide results for 3 different test scenes containing a high number of polygons.
Cross‐Linked g‐C<sub>3</sub>N<sub>4</sub>/rGO Nanocomposites with Tunable Band Structure and Enhanced Visible Light Photocatalytic Activity (2013)

Cross-linked rather than non-covalently bonded graphitic carbon nitride (g-C3 N4 )/reduced graphene oxide (rGO) nanocomposites with tunable band structures have been successfully fabricated by thermal treatment of a mixture of cyanamide and graphene oxide with different weight ratios. The experimental results indicate that compared to pure g-C3 N4 , the fabricated CN/rGO nanocomposites show narrowed bandgaps with an increased in the rGO ratio. Furthermore, the band structure of the CN/rGO nanocomposites can be readily tuned by simply controlling the weight ratio of the rGO. It is found that an appropriate rGO ratio in nanocomposite leads to a noticeable positively shifted valence band edge potential, meaning an increased oxidation power. The tunable band structure of the CN/rGO nanocomposites can be ascribed to the formation of C-O-C covalent bonding between the rGO and g-C3 N4 layers, which is experimentally confirmed by Fourier transform infrared (FT-IR) and X-ray photoelectron (XPS) data. The resulting nanocomposites are evaluated as photocatalysts by photocatalytic degradation of rhodamine B (RhB) and 4-nitrophenol under visible light irradiation (λ > 400 nm). The results demonstrate that the photocatalytic activities of the CN/rGO nanocomposites are strongly influenced by rGO ratio. With a rGO ratio of 2.5%, the CN/rGO-2.5% nanocomposite exhibits the highest photocatalytic efficiency, which is almost 3.0 and 2.7 times that of pure g-C3 N4 toward photocatalytic degradation of RhB and 4-nitrophenol, respectively. This improved photocatalytic activity could be attributed to the improved visible light utilization, oxidation power, and electron transport property, due to the significantly narrowed bandgap, positively shifted valence band-edge potential, and enhanced electronic conductivity.
Quantum dots as single-photon sources for quantum information processing (2005)

Semiconductor pillar microcavities containing quantum dots have shown promise as efficient sources of single and correlated pairs of photons, which may find applications in quantum information processing. In this paper we discuss the use of these sources to generate single photons and the use of pillars with elliptical cross-section to enhance and select a particular photon state. Single-photon interference measurements are also performed and show coherence times of up to 180 ps for quasi-resonantly pumped dots. Hong–Ou–Mandel-type two-photon interference measurements using a fibre interferometer indicate that individually created photons display a large degree of indistinguishability.
Near-field-magnetic-tweezer manipulation of single DNA molecules (2004)

We have developed an instrument for micromanipulation of single DNA molecules end labeled with 3-microm-diameter paramagnetic particles. A small, permanent magnet that can be moved as close as 10 microm to the particle being manipulated can generate forces in excess of 200 pN, significantly larger than obtained in other recent "magnetic-tweezer" studies. Our instrument generates these forces in the focal plane of a microscope objective, allowing straightforward real-time observation of molecule extension with a position resolution of approximately 30 nm. We show how our magnetic manipulation system can be combined with manipulation and force measurement using glass micropipettes to allow rapid switching between measurements in fixed-force and fixed-extension ensembles. We demonstrate the use of our system to study formation of DNA loops by an enzyme which strongly binds two copies of a specific 6-base-pair sequence.
Occupational asthma and IgE sensitization in a pharmaceutical company processing psyllium. (1987)

We assessed the prevalence of occupational asthma and IgE sensitization to psyllium in a pharmaceutical company producing psyllium hydrophilic mucilloid, which is used as a laxative. Workers were intermittently exposed, approximately 5 times/yr, for periods of less than 10 days. Of the 140 employees, 130 (93%) were studied before a processing period via a questionnaire spirometry (n = 125), blood sampling (n = 118), and skin prick tests (n = 120) with 7 common inhaled allergens as well as plantain and psyllium. Thirty-nine workers had a history suggestive of occupational asthma. Twenty-three of 120 (19%) showed a skin wheal diameter greater than or equal to 3 mm to psyllium and 31 of 118 (26%) had increased specific IgE antibodies; 39 (32%) workers had at least 1 of these 2 features. Subjects with a questionnaire suggestive of asthma or occupational asthma were further investigated by serial monitoring of peak expiratory flow rates and PC20 methacholine before and during the psyllium processing period. All workers had spirometry repeated during the processing period. Twenty-one subjects who had a PC20 less than or equal to 16 mg/ml (n = 10) and/or decreased their PC20 by a greater than or equal to 3.2-fold difference (n = 4) and/or changed their FEV1 by greater than or equal to 10% (n = 13) during the processing period were referred for inhalation challenges to psyllium in the laboratory. Five of the 18 workers for whom these tests were feasible gave an immediate bronchoconstrictive reaction.(ABSTRACT TRUNCATED AT 250 WORDS)
Cs+- Doped Poly-Perfluorosulfonate Membranes for Application in Direct Methanol Fuel Cells (1998)

Poly-perfluorosulfonic acid membranes were doped with cesium ions to several degrees. These, along with the H+- form membrane, were investigated in relation to methanol permeability as well as to hydrogen ion conductivity at room temperature. While retaining considerable conductivity, the cesium doped membranes are highly impermeable to methanol. We found that methanol permeability in the membrane reduced by almost two orders of magnitude, owing to the presence of cesium ions. These findings are discussed on the ground of the alterations produced by cesium in membrane micro-structure. Also presented are some preliminary results relative to the permeability and conductivity in these membranes at temperatures up to 60 °C.
Levels of Expression of <b> <i>CYR61</i> </b> and <b> <i>CTGF</i> </b> Are Prognostic for Tumor Progression and Survival of Individuals with Gliomas (2004)

The biological properties of CCN proteins include stimulation of cell proliferation, migration, and adhesion, as well as angiogenesis and tumorigenesis. We quantified CYR61, CTGF, WISP-1, and NOV mRNA expression levels in samples from sixty-six primary gliomas and five normal brain samples using quantitative real-time PCR assay. Statistical analysis was performed to explore the links between expression of the CCN genes and clinical and pathological parameters. Overexpression of CYR61, CTGF, WISP-1, and NOV occurred in 48% (32 of 66), 58% (38 of 66), 36% (24 of 66), and 15% (10 of 66) of primary gliomas, respectively. Interestingly, significant associations were found between CYR61 expression versus tumor grade, pathology, gender, and age at diagnosis. Also, a significant correlation existed between CTGF mRNA levels versus tumor grade, gender, and pathology. In contrast to CYR61 and CTGF, no significant association was found between expression of either WISP-1 or NOV versus any of the pathological features. Furthermore, Cox regression analysis showed that CYR61 and CTGF expression had a significant correlation with patient survival. These results suggest that CYR61 and CTGF may play a role in the progression of gliomas; their levels at diagnosis may have prognostic significance; and these proteins might serve as valuable targets for therapeutic intervention.
Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV (2017)

Human respiratory syncytial virus (hRSV) is responsible for serious lower respiratory tract disease in infants and in older adults, and remains an important vaccine need. RSV fusion (F) glycoprotein is a key target for neutralizing antibodies. RSV F stabilized in its pre-fusion conformation (DS-Cav1 F) induces high neutralizing antibody titers in naïve animals, but it remains unknown to what extent pre-fusion F can boost pre-existing neutralizing responses in RSV seropositive adults. We here assess DS-Cav1 F immunogenicity in seropositive cattle pre-exposed to bovine RSV, a virus closely related to hRSV. A single immunization with non-adjuvanted DS-Cav1 F strongly boosts RSV neutralizing responses, directed towards pre-fusion F-specific epitopes, whereas a post-fusion F is unable to do so. Vaccination with pre-fusion F thus represents a promising strategy for maternal immunization and for other RSV vaccine target populations such as older adults.
Large second harmonic generation in electrically ordered p-nitroaniline–poly(oxyethylene)‘Guest–Host’ systems (1988)

T. Watanabe, K. Yoshinaga, D. Fichou and S. Miyata, J. Chem. Soc., Chem. Commun., 1988, 250 DOI: 10.1039/C39880000250
Dual X-ray absorptiometry: a comparison between fan beam and pencil beam scans (1993)

The recent introduction of dual X-ray absorptiometry (DXA) systems with fan beam instead of conventional pencil beam scanning geometry represents a significant technical advance in bone densitometry. This report describes phantom and in-vivo studies of the effect of the change in beam configuration on DXA measurements. Fan beam and pencil beam measurements acquired on one of the new generation scanners, the Hologic QDR-2000, were compared with scans performed on an earlier pencil beam model, the Hologic QDR-1000. The variation with height above the scanning table of fan beam measurements of an anthropomorphic spine phantom were: bone mineral content (BMC): -3.1% cm-1; projected area (AREA): -2.8% cm-1; bone mineral density (BMD): -0.2% cm-1. For pencil beam scans the magnitude of height variation was less than 0.1% cm-1. QDR-2000 fan and pencil beam scan results for 20 volunteers correlated closely with QDR-1000 pencil beam data (r = 0.966-0.998). For BMD measurements on the spine and hip, differences between fan and pencil beam data were consistent with the errors expected from measurement precision. For AREA and BMC data, however, larger differences were observed with individual deviations which correlated with body habitus of the subjects. Although the change from pencil to fan beam geometry significantly affected AREA and BMC data, the effect on the clinically more important BMD measurements was negligibly small.
CORRELATIONS BETWEEN HEAVY METALS AND SUSPENDED SOLIDS IN HIGHWAY RUNOFF: IMPLICATIONS FOR CONTROL STRATEGIES (1995)

Cholesterol is an important component for cell physiology. It regulates the fluidity of cell membranes and determines the physical and biochemical properties of proteins. In the central nervous system, cholesterol controls synapse formation and function and supports the saltatory conduction of action potential. In recent years, the role of cholesterol in the brain has caught the attention of several research groups since a breakdown of cholesterol metabolism has been associated with different neurodevelopmental and neurodegenerative diseases, and interestingly also with psychiatric conditions. The aim of this review is to summarize the current knowledge about the connection between cholesterol dysregulation and various neurologic and psychiatric disorders based on clinical and preclinical studies. J. Cell. Physiol. 232: 281-286, 2017. © 2016 Wiley Periodicals, Inc.