gebhart/patrepeval huggingface dataset:
The accuracy and precision of curvature estimation methods (2003)

Deals with the estimation of curvature from digital image data, especially the selection of a curvature estimation procedure based on its accuracy and precision. The authors establish that almost all curvature estimation techniques from literature suffer from a severe directional inaccuracy and/or poor precision (errors depend on the method, orientation and scale ranging from 1% to more than 200%). A practical solution to the curvature estimation problem is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Solubilization and Characterization of Striatal Dopamine Receptors (1984)

Dopamine receptor binding proteins were solubilized with the detergent 3-(3-cholamidopropyl) dimethylammonio-2-hydroxy-1-propanesulfonate (CHAPSO) from bovine and rat striatal membranes. The binding of the dopamine antagonist [3H]spiroperidol [( 3H]Spi) to the solubilized dopamine receptors was determined by the polyethyleneglycol method. The CHAPSO-solubilized dopamine receptor binding proteins remain in the supernatant fraction following centrifugation at 100,000 X g for 2 h. The CHAPSO-solubilized dopamine receptor proteins, as well as the prelabeled [3H]Spi-receptor protein complex, bind specifically to wheat germ agglutinin (WGA)-agarose columns, which is consistent with an identification as glycoproteins, HPLC analysis of the CHAPSO-solubilized, prelabeled [3H]Spi-receptor protein complex (CHAPSO preparation) reveals association with a high molecular weight form, indicating the formation of aggregates and/or micelles. Treatment of the WGA-agarose-bound [3H]Spi-receptor protein complex with digitonin (CHAPSO-digitonin preparation) results in dissociation of the high molecular weight form into lower molecular weight forms. The HPLC profile of the prelabeled [3H]Spi-receptor complex in the CHAPSO-digitonin preparation reveals two radioactive peaks. The major peak had a retention time of 16 min, corresponding to an apparent MW of 175,000, whereas the minor peak had a retention time of 21 min, corresponding to an apparent MW of 49,000. The CHAPSO-solubilized dopamine receptor binding proteins are sensitive to modulation by GTP, indicating that the association with the GTP binding component is preserved in the "soluble" state. The potencies of dopamine antagonists and agonists for inhibiting the binding of [3H]Spi to CHAPSO-solubilized dopamine receptor proteins are similar to those for membrane-bound proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
Hilbert-Huang Transform-based Local Regions Descriptors (2007)

This paper presents a new interest local regions descriptors method based on Hilbert-Huang Transform. The neighborhood of the interest local region is decomposed adaptively into oscillatory components called intrinsic mode functions (IMFs). Then the Hilbert transform is applied to each component and get the phase and amplitude information. The proposed descriptors samples the phase angles information and amalgamates them into 10 overlap squares with 8-bin orientation histograms. The experiments show that the proposed descriptors are better than SIFT and other standard descriptors. Essentially, the Hilbert-Huang Transform based descriptors can belong to the class of phase-based descriptors. So it can provides a better way to overcome the illumination changes. Additionally, the Hilbert-Huang transform is a new tool for analyzing signals and the proposed descriptors is a new attempt to the Hilbert-Huang transform.
Preparation and evaluation of in situ gelling ophthalmic drug delivery system for methazolamide (2010)

These results suggested that in situ gelling ophthalmic drug delivery system may hold some promise in ocular MTA delivery.
Traducir del inglés y sus varias dificultades (1995)

Debo empezar por senalar que, a diferencia de mis companeros de mesa, en este momento no formo parte de un proyecto de traduccion ni tampoco estoy en vias de traducir algo. De hecho, mi ultima traduccion tiene ya dos anos en espera de ser publicada. Pero esto no quiere decir que no tenga yo experiencia como traductora y si he de decir la verdad he traducido mucho. Pero tambien aqui el camino seguido es distinto al de mis colegas. Ahora hay escuelas de traductores y cuando yo empece no las habia. Aprendi los idiomas que manejo por la sencilla razon de que formaban parte de los estudios en el Colegio Aleman donde me eduque, sin que nunca se me ocurriera que algun dia pudieran servirme para algo mas que leer un libro en provecho o para placer propio. Las cosas cambiaron al ingresar al seminario del doctor Jose Gaos. Como solo aceptaba a los alumnos despues de una larga entrevista y en ella salieran a relucir mis posibilidades como traductora, poco tiempo despues me recomendo como tal al Fondo de Cultura Economica. Alli, tras hacer una breve prueba en cada uno de los idiomas que, a mi parecer, podia traducir (pruebas que fueron corregidas por el propio Gaos), empece a trabajar. Pero no como traductora, sino—para mi gran sorpresa—como revisora de las traducciones de libros de filosofia, historia y religion hechas por otros. Puedo decir, en consecuencia, que soy una de las pocas personas que han experimentado en cabeza ajena. A partir de los errores cometidos por otros, aprendi lo que no hay que hacer. En primer lugar, nunca intentar traducir un tema que no se conoce. Si nuestros cono cimientos se limitan a la fisica, pongamos por caso, nunca debe aceptarse traducir un texto de historia del arte. Esto, que parece una verdad de Perogrullo, es basico. Por bien que se conozcan dos idiomas, debe tenerse conciencia de que cada rama del saber humano tiene su propia terminologia que, en la mayoria de
A Review of Flavoxate Hydrochloride in the Treatment of Urge Incontinence (1988)

This article provides a review of the use of flavoxate hydrochloride in the treatment of urge incontinence. It outlines the pharmacology, mode of action, toxicology and pharmacokinetic studies which have been carried out, and then reviews the clinical studies, including those involving patients with benign prostatic hypertrophy. The effects of dosages of 600-1200 mg/day are compared, particularly regarding safety and tolerability factors. Finally, alternative therapies to flavoxate hydrochloride (alpha-adrenergic receptor blockers, oxybutinin chloride, terodiline hydrochloride, emepronium bromide and imipramine) are summarized. The article is written in the knowledge of recent evidence which indicates that flavoxate hydrochloride exhibits only weak anticholinergic activity on receptors involved in the control of the lower urinary tract.
Deaths Resulting From Hypocalcemia After Administration of Edetate Disodium: 2003-2005 (2006)

From 2003 to 2005, deaths of 3 individuals as a result of cardiac arrest caused by hypocalcemia during chelation therapy were reported to the Centers for Disease Control and Prevention. Two were children, both of whom were treated with edetate disodium. At the time of this writing, the adult case was still under investigation. No previous cases of death resulting from hypocalcemia during chelation have been reported. From our experience and review of the literature, we suggest that health care providers who are unfamiliar with chelation consult an expert before undertaking treatment and that hospital formularies evaluate whether stocking edetate disodium is necessary, given the risk for hypocalcemia and the availability of less toxic alternatives.
Manipulating Interfaces through Surface Confinement of Poly(glycidyl methacrylate)-<i>block</i>-poly(vinyldimethylazlactone), a Dually Reactive Block Copolymer (2012)

The assembly of dually reactive, well-defined diblock copolymers incorporating the chemoselective/functional monomer, 4,4-dimethyl-2-vinylazlactone (VDMA) and the surface-reactive monomer glycidyl methacrylate (GMA) is examined to understand how competition between surface attachment and microphase segregation influences interfacial structure. Reaction of the PGMA block with surface hydroxyl groups not only anchors the copolymer to the surface, but limits chain mobility, creating brush-like structures comprising PVDMA blocks, which contain reactive azlactone groups. The block copolymers are spin coated at various solution concentrations and annealed at elevated temperature to optimize film deposition to achieve a molecularly uniform layer. The thickness and structure of the polymer thin films are investigated by ellipsometry, infrared spectroscopy, and neutron reflectometry. The results show that deposition of PGMA-b-PVDMA provides a useful route to control film thickness while preserving azlactone groups that can be further modified with biotin–poly(ethylene glycol)amine to generate designer surfaces. The method described herein offers guidance for creating highly functional surfaces, films, or coatings through the use of dually reactive block copolymers and postpolymerization modification.
Cyanogen-Oxygen Flame (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyanogen-Oxygen FlameB. L. Vallee and A. F. BartholomayCite this: Anal. Chem. 1956, 28, 11, 1753–1755Publication Date (Print):November 1, 1956Publication History Published online1 May 2002Published inissue 1 November 1956https://pubs.acs.org/doi/10.1021/ac60119a032https://doi.org/10.1021/ac60119a032research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simulating Human Cardiac Electrophysiology on Clinical Time-Scales (2011)

In this study, the feasibility of conducting in silico experiments in near-realtime with anatomically realistic, biophysically detailed models of human cardiac electrophysiology is demonstrated using a current national high-performance computing facility. The required performance is achieved by integrating and optimizing load balancing and parallel I/O, which lead to strongly scalable simulations up to 16,384 compute cores. This degree of parallelization enables computer simulations of human cardiac electrophysiology at 240 times slower than real time and activation times can be simulated in approximately 1 min. This unprecedented speed suffices requirements for introducing in silico experimentation into a clinical workflow.
Linearized tomographic inversion of first-arrival times (1992)

Abstract A linearized tomographic-inversion algorithm estimates the near-surface slowness anomalies present in a conventional, shallow-marine seismic reflection data set. First-arrival time residuals are the data to be inverted. The anomalies are treated as perturbations relative to a known, laterally-invariant reference velocity model. Below the sea floor the reference model varies smoothly with depth; consequently the first arrivals are considered to be diving waves. In the offset-midpoint domain the geometric patterns of traveltime perturbations produced by the anomalies resemble hyperbolas. Based on simple ray theory, these geometric patterns are predictable and can be used to relate the unknown model to the data. The assumption of a laterally-invariant reference model permits an efficient solution in the offset-wavenumber domain which is obtained in a single step using conventional least squares. The tomographic image shows the vertical-traveltime perturbations associated with the anomalies as a function of midpoint at a number of depths. As implemented, the inverse problem is inherently stable.The first arrivals sample the subsurface to a maximum depth of roughly 500 m ( nearly equal one-fifth of the spread length). The model is parameterized to consist of fifteen 20-m thick layers spanning a depth range of 80-380 m. One-way vertical-traveltime delays as large as 10 ms are estimated. Assuming that these time delays are distributed over the entire 20-m thick layers, velocities much slower than water velocity are implied for the anomalies. Maps of the tomographic images show the spatial location and orientation of the anomalies throughout the prospect for the upper 400 m. Each line is processed independently, and the results are corroborated to a high degree at the line intersections.
Textbook of Canine and Feline Cardiology: Principles and Clinical Practice (1999)

The Normal Heart: Cardiovascular Structure, Function and Physiology. Examination of the Patient with Cardiovascular Disease. Diagnostic Methods. Abnormal Cardiovascular Function and Principles of Therapy. Diseases of the Heart and Circulation. Effects of Systemic and Metabolic Disorders on the Heart. Cardiovascular Pathology. Cardiovascular Surgery and Procedures.
Interregional synaptic maps among engram cells underlie memory formation (2018)

Memory resides in engram cells distributed across the brain. However, the site-specific substrate within these engram cells remains theoretical, even though it is generally accepted that synaptic plasticity encodes memories. We developed the dual-eGRASP (green fluorescent protein reconstitution across synaptic partners) technique to examine synapses between engram cells to identify the specific neuronal site for memory storage. We found an increased number and size of spines on CA1 engram cells receiving input from CA3 engram cells. In contextual fear conditioning, this enhanced connectivity between engram cells encoded memory strength. CA3 engram to CA1 engram projections strongly occluded long-term potentiation. These results indicate that enhanced structural and functional connectivity between engram cells across two directly connected brain regions forms the synaptic correlate for memory formation.
Dopant channeling as a function of implant angle for low energy applications (2003)

The formation of ultra-shallow junctions requires that channeling of the dopant beam by the silicon lattice be avoided to minimize junction depth. This can be accomplished by techniques such as pre-amorphization of the silicon substrate, thereby adding an extra process step in the device fabrication process. A simpler approach is to extend the use of the implant angle of the silicon lattice relative to the beam. At high energies, the use of a 7 degree implant angle is typical to avoid channeling. As the implant energy is reduced, the acceptance angle for channeling grows, thus larger implant angles may be required. Unfortunately, the capability of most high current machines is limited to implant angles of about 10 degrees or less. In this paper, the effect of tilt angle on channeling for low energies is investigated on the Varian VIISta 80 serial high current implanter, which allows the use of implant angles up to 60 degrees.
Effect of RF interference on characteristics of DC SQUID system (1993)

The effects of RF interference on the characteristics of DC superconducting quantum interference devices (SQUIDs) are investigated. The noise of a DC SQUID gradiometer radiating an RF field with a frequency between 100 kHz and 80 MHz was measured. As the RF field strength intensified, the white noise level increased and the cut-off frequency was lowered. The flux-voltage transfer function (dV/d Phi ) of the DC SQUID was influenced strongly by the RF field. dV/d Phi decreased as the RF field intensified. Based on these results, the level of the electromagnetic environment at which the operation of the SQUID system would not be affected was found. The effect of high-frequency magnetic field on the flux to voltage transfer function was investigated by computer simulation using a simple resistively shunted junction (RSJ) model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Serpens flexibilis gen. nov., sp. nov., an Unusually Flexible, Lactate-Oxidizing Bacterium (1977)

An extremely flexible, motile, rod-shaped bacterium (0.3 to 0.35 by 8 to 12 μm) was isolated from samples of pond mud. The organism can readily move through media containing 1% (wt/vol) agar. Only subsurface, spreading growth occurs on media containing less than 1.5% (wt/vol) agar. In agar media, cells displayed serpentine-like motility and rapidly coiled and uncoiled into a variety of knot forms. The organism possesses a gram-negative type of cell envelope with a peptidoglycan layer containing muramic acid, glucosamine, glutamic acid, diaminopimelic acid, and alanine in a ratio of 1.0/1.0/1.0/1.0/2.0, respectively. The cells possess bacterial flagella which occur both in bipolar tufts (4 to 10 flagella per tuft) and, to a lesser extent, singly over the surface of the cell. The organism only grew aerobically. Among the substrates tested, lactate was the only major energy and carbon source used. Carbohydrates, fatty acids, and amino acids did not support growth. Casein hydrolysate, peptone, and NH4Cl were used as nitrogen sources. Although both vitamin mixtures and yeast extract stimulated growth, no vitamins were required for growth. Cell extracts contain high levels of tricarboxylic acid cycle enzyme activities but only trace levels of glycolytic enzyme activities. The guanine-plus-cytosine content of the deoxyribonucleic acid of the organism is 65.8 mol% (strain PFR-1, buoyant density). For this organism, apparently previously undescribed, the name Serpens flexibilis gen. nov., sp. nov. is proposed. The type strain of S. flexibilis is PFR-1 (=ATCC 29606).
Activation of mouse lymphocytes inhibits induction of rapid cell death by x-irradiation. (1985)

A distinctive property of the resting lymphocyte is its ability to die rapidly in interphase after x-irradiation. Suspensions of thymocytes and peripheral lymphocytes from BALB/c mice were irradiated with doses ranging from 10 to 10,000 rad (0.1 to 100 Grays), and their viability was measured by eosin dye exclusion at intervals through 3 days of culture. After an initial latent period of a few hours, viability declined exponentially in a dose-dependent fashion. Doses as low as 20 rad caused some lymphocytes to die rapidly. After 1000 rad, 90% of the cells became nonviable in 15 to 20 hr and 99% in 25 to 35 hr. Peripheral lymphocytes showed a somewhat earlier loss of viability than did thymocytes, and were killed especially rapidly by 10,000 rad. Enriched T cells and B cells were killed by irradiation at equal rates, and medullary thymocytes were killed at the same rate as the whole thymocyte population. In contrast with resting cells, T and B lymphocytes activated by mitogens were not subject to such rapid induction of cell death. Irradiation with 1000 rad reduced the viability of activated cells by only 50% at a time when less than 1% of nonstimulated lymphocytes remained alive. Similarly, cloned lines of antigen-specific helper and cytotoxic T cells showed only a delayed and slow loss of viability after receiving 1000 rad. The state of activation can therefore be a significant determinant of the immunologic consequences of irradiation.
Serum KL‐6 levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis (2009)

To evaluate whether KL-6 concentration is a useful biomarker of the severity of respiratory syncytial virus (RSV) bronchiolitis, we determined KL-6 concentrations in patients with RSV bronchiolitis with or without chronic heart disease (CHD). We enrolled 52 patients who had been diagnosed with RSV bronchiolitis and required admission to the hospital at the Department of Pediatrics of Fukushima Medical University School of Medicine from 2004 to 2005. These patients were divided into two groups: Group 1 consisted of patients without any underlying disease, and Group 2 consisted of patients with CHD. These patients were assigned to three categories. Stage A consisted of patients without oxygen dosage, stage B of patients who required oxygen dosage, and stage C of patients required artificial respiration. We evaluated baseline characteristics, clinical features, and serum KL-6 concentration in Group 1, Group 2, and a control group (healthy infants without infection). Mean serum KL-6 concentrations in patients with RSV bronchiolitis were higher than those in the control group (471.8 +/- 236.9 and 127.1 +/- 69.1 U/ml, respectively). Mean serum KL-6 concentration was higher in Group 2 than in Group 1 (692.8 +/- 313.1 and 390.4 +/- 132.7 U/ml, respectively). Mean serum KL-6 concentrations were higher in stage C than in stages A and B, and mean serum KL-6 concentrations were higher in stage B than in stage A. These findings suggest that serum KL-6 is associated with the severity of RSV bronchiolitis and that it may be a useful biomarker for the severity of RSV bronchiolitis.
Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses. (2001)

Earlier, we have detected antiviral activity in an extract from Ribes nigrum L. fruits ("Kurokarin", name of the one species of black currant in Japanese) against influenza A and B viruses, and herpes simplex virus 1 (Knox et al., Food Processing 33, 21-23, 1998). In the present study, the antiviral activity of constituents of a Kurokarin extract and the mechanism of its antiviral action were examined. Kurokarin extracts were separated to fractions A to D by column chromatography. The major constituents of the fraction D were estimated as anthocyanins. The fraction D was further fractionated by thin-layer chromatography (TLC) to fractions A' to G'. The fraction E' consisted of 3-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyl-cyanidin and 3-O-beta-D-glucopyranosyl-cyanidin, and the fraction F' consisted of 3-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyl-delphinidin and 3-O-beta-D-glucopyranosyl-delphinidin, identified by high performance liquid chromatography (HPLC) with standards and by high resolution mass spectrometry. The fractions D' to G' showed potent antiviral activity against influenza viruses A and B. The additive antiviral effect of a combination of the fractions E' and F' was assessed. Anthocyanins in the fraction F' did not directly inactivate influenza viruses A and B, but they inhibited virus adsorption to cells and also virus release from infected cells.
Metabolic Actions of Adipocyte Hormones: Focus on Adiponectin (2006)

The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin-sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity-related diseases and a potential therapeutic target.
Visual performance effects and user acceptance of the M43A1 aviation protective mask frontserts. (1995)

Within the range of flight conditions and profiles examined, the M43A1 frontsert system meets U.S. Army aviation needs for optical correction when mission requirements dictate flying with chemical-biological protective masks.