gebhart/patrepeval huggingface dataset:
Fluconazole resistance in AIDS patients (1991)

Journal Article Fluconazole resistance in AIDS patients Get access LORNA WILLOCKS, LORNA WILLOCKS Regional Infections Diseases Unit, City HospitalGreenbank Drive, Edinburgh EH10 5SB, and Mycology UnitCentral Microbiological Laboratories, Western General HospitalEdinburgh EH4 2XU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar C. L. S. LEEN, C. L. S. LEEN Regional Infections Diseases Unit, City HospitalGreenbank Drive, Edinburgh EH10 5SB, and Mycology UnitCentral Microbiological Laboratories, Western General HospitalEdinburgh EH4 2XU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar R. P. BRETTLE, R. P. BRETTLE Regional Infections Diseases Unit, City HospitalGreenbank Drive, Edinburgh EH10 5SB, and Mycology UnitCentral Microbiological Laboratories, Western General HospitalEdinburgh EH4 2XU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar D. URQUHART, D. URQUHART Regional Infections Diseases Unit, City HospitalGreenbank Drive, Edinburgh EH10 5SB, and Mycology UnitCentral Microbiological Laboratories, Western General HospitalEdinburgh EH4 2XU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar T. B. RUSSELL, T. B. RUSSELL Regional Infections Diseases Unit, City HospitalGreenbank Drive, Edinburgh EH10 5SB, and Mycology UnitCentral Microbiological Laboratories, Western General HospitalEdinburgh EH4 2XU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar L. J. R. MILNE L. J. R. MILNE Regional Infections Diseases Unit, City HospitalGreenbank Drive, Edinburgh EH10 5SB, and Mycology UnitCentral Microbiological Laboratories, Western General HospitalEdinburgh EH4 2XU, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 28, Issue 6, December 1991, Pages 937–939, https://doi.org/10.1093/jac/28.6.937 Published: 01 December 1991
Update 1 of: Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure (2010)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTUpdate 1 of: Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn StructureGloria Ruiz-Gómez, Joel D. A. Tyndall†, Bernhard Pfeiffer†, Giovanni Abbenante, and David P. Fairlie*View Author Information Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane Qld 4072, Australia* Corresponding author: fax, +61-733462990; e-mail, [email protected]†Current mailing addresses: J. Tyndall, National School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand; B.Pfeiffer, Institute of Pharmaceutical Science D-CHAB, ETH Hoenggerberg HCI H492.4, Wolfang-Pauli-Str. 10, CH-8093 Zurich, Switzerland.Cite this: Chem. Rev. 2010, 110, 4, PR1–PR41Publication Date (Web):March 2, 2010Publication History Received19 October 2009Published online31 March 2010Published inissue 14 April 2010https://pubs.acs.org/doi/10.1021/cr900344whttps://doi.org/10.1021/cr900344wreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views3449Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antagonists,Chemical structure,Conformation,Peptides and proteins,Receptors Get e-Alerts
[New systemic therapies of psoriasis]. (1985)

The metabolic-pathophysiological pathways are of prime importance when considering psoriasis therapy. Present-day concepts recognize that central growth hormone controls the metabolic route and that the peripheral pathway is under the control of several growth factors. Both the central and peripheral pathways induce pathological proliferation. A selection of six routine drugs, all with specific biochemical properties, induced part to total remission in about 75% of the 442 psoriasis patients.
Nanoparticle Contrast in Magneto-Motive Optical Doppler Tomography (2006)

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter <TEX>${\sim}100nm$</TEX>) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength (<TEX>$B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$</TEX>) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.
Packet delay and packet loss in the Internet (2003)

The distribution characteristic of RTT (round-trip time) is an important part of Internet end-to-end behavior characteristics. People have made lots of studies of it, but many conclusions only adapt to the cases of small packet loss rate. We study the RTT characteristics on nearly 40 end-to-end paths in CSTNET and CERNET in China, and draw the following conclusions: (1) the distribution characteristics of RTT and loss rate are dependable; (2) when loss rate is small, RTT distribution is usually unimodal, but with the increase of loss rate, RTT distribution is no longer unimodal and it becomes more and more decentralized; (3) with the increase of loss rate, the occurring times of inherent RTT tend to decrease.
Cytokine regulation of lung fibroblast proliferation. Pulmonary and systemic changes in asbestos-induced pulmonary fibrosis. (1986)

A complex series of interactions between immunocompetent cells and fibroblasts exists. Because pulmonary fibrosis may result from an increased number of collagen-producing fibroblasts, we studied the production of fibroblast growth factors derived from alveolar macrophages (AM) and peripheral blood mononuclear leukocytes (PBML) during the development of asbestos-induced fibrosis. Three groups of rats received, respectively, a single intratracheal injection of saline (control), 5 mg of asbestos, and 10 mg of asbestos. Bronchoalveolar lavage (BAL) and PBML isolation were performed on each animal 1, 3, and 6 months after instillation. Differential cell analyses revealed no significant change in the BAL cell populations except for a small but significant increase in the proportion of lymphocytes in the 10-mg group at 1 month and in both asbestos groups at 3 months. Similar analyses of PBML revealed only a small reduction in total PBML in the 10-mg group at 6 months. Bronchoalveolar cells (98% AM) from control rats spontaneously released a fibroblast growth factor (FGF), whereas Con-A-stimulated PBML of the same animals produced fibroblast growth inhibitory activity (FGIF). One month after asbestos exposure, when fibrotic lesions were apparent, AM production of FGF was significantly enhanced, and such increase persisted for as long as 6 months. By contrast, no significant change in FGIF production by Con-A-stimulated PBML was seen at the 1-month interval. However, 3 months after exposure, there was a significant suppression of FGIF production by PBML from rats in the 10-mg group and at 6 months by PBML from rats in both asbestos groups.(ABSTRACT TRUNCATED AT 250 WORDS)
PML bodies associate specifically with the MHC gene cluster in interphase nuclei (2001)

Promyelocytic leukemia (PML) bodies are nuclear multi-protein domains. The observations that viruses transcribe their genomes adjacent to PML bodies and that nascent RNA accumulates at their periphery suggest that PML bodies function in transcription. We have used immuno-FISH in primary human fibroblasts to determine the 3D spatial organisation of gene-rich and gene-poor chromosomal regions relative to PML bodies. We find a highly non-random association of the gene-rich major histocompatibilty complex (MHC) on chromosome 6 with PML bodies. This association is specific for the centromeric end of the MHC and extends over a genomic region of at least 1.6 megabases. We also show that PML association is maintained when a subsection of this region is integrated into another chromosomal location. This is the first demonstration that PML bodies have specific chromosomal associations and supports a model for PML bodies as part of a functional nuclear compartment.
Kinetics of Ribosomal Pausing during Programmed −1 Translational Frameshifting (2000)

In the Saccharomyces cerevisiae double-stranded RNA virus, programmed -1 ribosomal frameshifting is responsible for translation of the second open reading frame of the essential viral RNA. A typical slippery site and downstream pseudoknot are necessary for this frameshifting event, and previous work has demonstrated that ribosomes pause over the slippery site. The translational intermediate associated with a ribosome paused at this position is detected, and, using in vitro translation and quantitative heelprinting, the rates of synthesis, the ribosomal pause time, the proportion of ribosomes paused at the slippery site, and the fraction of paused ribosomes that frameshift are estimated. About 10% of ribosomes pause at the slippery site in vitro, and some 60% of these continue in the -1 frame. Ribosomes that continue in the -1 frame pause about 10 times longer than it takes to complete a peptide bond in vitro. Altering the rate of translational initiation alters the rate of frameshifting in vivo. Our in vitro and in vivo experiments can best be interpreted to mean that there are three methods by which ribosomes pass the frameshift site, only one of which results in frameshifting.
Attitudes toward prevention of mtDNA-related diseases through oocyte mitochondrial replacement therapy (2016)

Not applicable.
Towards workload-aware self-management: Predicting significant workload shifts (2010)

The workloads of enterprise DBS often show periodic patterns, e.g. because there are mainly OLTP transactions during day-time and analysis operations at night. However, current DBS self-management functions do not consider these periodic patterns in their analysis. Instead, they either adapt the DBS configuration to an overall ¿average¿ workload, or they reactively try to adapt the DBS configuration after every periodic change as if the workload had never been observed before. In this paper we propose a periodicity detection approach, which allows the prediction of workload changes for DBS self-management functions. For this purpose, we first describe how recurring DBS workloads, i.e. workloads that are similar to workloads that have been observed in the past, can be identified. We then propose two different approaches for detecting periodic patterns in the history of recurring DBS workloads. Finally we show how this knowledge on periodic patterns can be used to predict workload changes, and how it can be adapted to changes in the periodic patterns over time.
Text categorization (2005)

Welcome to the WIT Press eLibrary - the home of the Transactions of the Wessex Institute collection, providing on-line access to papers presented at the Institute's prestigious international conferences and from its State-of-the-Art in Science & Engineering publications.
Solar wireless power transfer using inductive coupling for mobile phone charger (2014)

A wireless power transfer (WPT) using inductive coupling for mobile phone charger is studied. The project is offer to study and fabricate solar WPT using inductive coupling for mobile phone charger that will give more information about distance is effect for WPT performance and WPT is not much influenced by the presence of hands, books and types of plastics. The components used to build wireless power transfer can be divided into 3 parts components, the transceiver for power transmission, the inductive coils in this case as the antenna, receiver and the rectifier which act convert AC to DC. Experiments have been conducted and the wireless power transfer using inductive coupling is suitable to be implemented for mobile phone charger.
Theoretical and Experimental Vibrational Characterizations of Amine-Coated Silver Nanoparticles (2008)

Vibrational spectra of neutral and cationic amines on a silver surface were studied by using experimental and theoretical methods in combination. This work provides a prescription for identifying the charged state of amine on silver nanoparticles. In regards to the experiment, the infrared (IR) spectrum of silver nanoparticles (Ag-NPs) coated by neutral octylamine was measured by Fourier transformed IR. In regards to the calculations, vibrational spectra of neutral and cationic octylamine, adsorbed on a silver surface, were obtained by density-functional BPW91 calculations. The calculations show that amines of different charged states, i.e., neutral or cationic, can clearly be distinguished by the characteristic frequencies of N−H stretching and wagging modes. A comparison between the calculated and experimentally measured spectra of the Ag-NPs revealed that the amine in the synthesized Ag-NPs actually takes the neutral form. In addition, the synthesized Ag-NPs are shown to contain a non-negligible amount of residual ascorbic acid as well as some oxidized amines. In one of the IR spectra of amine-coated Ag-NPs measured prior to this study, the amine was found to be likely to take the cationic form. The current study demonstrates that a combination of theoretical calculations and experiments will help in characterizing the structure and constitution of organic species adsorbed on a metal surface.
Local Mosquito-Borne Transmission of Zika Virus — Miami-Dade and Broward Counties, Florida, June–August 2016 (2016)

During the first 6 months of 2016, large outbreaks of Zika virus disease caused by local mosquito-borne transmission occurred in Puerto Rico and other U.S. territories, but local mosquito-borne transmission was not identified in the continental United States (1,2). As of July 22, 2016, the Florida Department of Health had identified 321 Zika virus disease cases among Florida residents and visitors, all occurring in either travelers from other countries or territories with ongoing Zika virus transmission or sexual contacts of recent travelers.* During standard case investigation of persons with compatible illness and laboratory evidence of recent Zika virus infection (i.e., a specimen positive by real-time reverse transcription-polymerase chain reaction [rRT-PCR], or positive Zika immunoglobulin M [IgM] with supporting dengue serology [negative for dengue IgM antibodies and positive for dengue IgG antibodies], or confirmation of Zika virus neutralizing antibodies by plaque reduction neutralization testing [PRNT]) (3), four persons were identified in Broward and Miami-Dade counties whose infections were attributed to likely local mosquito-borne transmission. Two of these persons worked within 120 meters (131 yards) of each other but had no other epidemiologic connections, suggesting the possibility of a local community-based outbreak. Further epidemiologic and laboratory investigations of the worksites and surrounding neighborhood identified a total of 29 persons with laboratory evidence of recent Zika virus infection and likely exposure during late June to early August, most within an approximate 6-block area. In response to limited impact on the population of Aedes aegypti mosquito vectors from initial ground-based mosquito control efforts, aerial ultralow volume spraying with the organophosphate insecticide naled was applied over a 10 square-mile area beginning in early August and alternated with aerial larviciding with Bacillus thuringiensis subspecies israelensis (Bti), a group biologic control agent, in a central 2 square-mile area. No additional cases were identified after implementation of this mosquito control strategy. No increases in emergency department (ED) patient visits associated with aerial spraying were reported, including visits for asthma, reactive airway disease, wheezing, shortness of breath, nausea, vomiting, or diarrhea. Local and state health departments serving communities where Ae. aegypti, the primary vector of Zika virus, is found should continue to actively monitor for local transmission of the virus.(†).
Feasibility Investigation and Modeling Analysis of CO2 Sequestration in Arbuckle Formation Utilizing Salt Water Disposal Wells (2009)

The rate of CO2 production in many states, primarily from coal-fired power plants, is such that it only takes a few years to fill up any depleted oil and gas reservoirs. In order to reduce the level of CO2 in the atmosphere and to minimize the cost of sequestration, the injection of CO2 into aquifers utilizing disposal wells has been targeted. In this paper, an analysis of one particular case, namely, the Arbuckle formation in Oklahoma, was carried out to demonstrate its feasibility for CO2 sequestration. First, a general review for CO2 sequestration into aquifers utilizing existing disposal wells is presented. The limiting criteria for CO2 sequestration in terms of the geology of the aquifer, lithology of the host rock, cost of operation, impact on reservoir properties, depth of the completed interval to maintain supercritical conditions for CO2, injection pressure and rate to minimize gravity segregation, mobility ratio to prevent viscous fingering, and chemical interaction of aqueous and solid phases are discussed. Then, the existence of residual oil in the aquifer and its effect on reaction chemistry concerning the potential CO2 sequestration applications in the Arbuckle formation are evaluated. This investigation was conducted by means of simulation of the prevailing processes. The cutoff points from dissolution to precipitation for each constituent in terms of different CO2 injection rates were obtained by utilizing the simulation models GEM-GHG and PHREEQC and were supported by a database of 150 disposal wells from which 25 wells were completed in the Arbuckle formation. We critically evaluate the current state of knowledge, identify areas needing research, and offer practical approaches for the evaluation of potential CO2 sequestration sites using commercial disposal wells.
Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity (2009)

Helminths are masterful immunoregulators. A characteristic feature of helminth infection is a Th2-dominated immune response, but stimulation of immunoregulatory cell populations, such as regulatory T cells and alternatively activated macrophages, is equally common. Typically, Th1/17 immunity is blocked and productive effector responses are muted, allowing survival of the parasite in a "modified Th2" environment. Drug treatment to clear the worms reverses the immunoregulatory effects, indicating that a state of active suppression is maintained by the parasite. Hence, research has focussed on "excretory-secretory" products released by live parasites, which can interfere with every aspect of host immunity from initial recognition to end-stage effector mechanisms. In this review, we survey our knowledge of helminth secreted molecules, and summarise current understanding of the growing number of individual helminth mediators that have been shown to target key receptors or pathways in the mammalian immune system.
Dendron-Controlled Nucleation and Growth of Gold Nanoparticles (2001)

Passivation of the metal surface by dendrons bearing a focal 4-pyridone functionality (the second-generation dendron is shown; C: gray, N: blue, O: red) allows controlled nucleation and growth of gold nanoclusters. The particle size is a direct function of the generation number of the dendritic ligands, with higher generation dendron producing larger particles.
Establishment of a patterned GAL4‐VP16 transactivation system for discovering gene function in rice (2006)

A binary GAL4-VP16-UAS transactivation system has been established in rice (Oryza sativa L.) in this study for the discovery of gene functions. This binary system consists of two types of transgenic lines, pattern lines and target lines. The pattern lines were produced by transformation of Zhonghua 11, a japonica cultivar, with a construct consisting of the transactivator gene GAL4-VP16 controlled by a minimal promoter and the GUSplus reporter controlled by the upstream activation sequence (UAS; cis-element to GAL4). Target lines were generated by transformation of Zhonghua 11 with constructs carrying the EGFP reporter and target genes of interest, both controlled by the UAS but in opposite directions. Hybrid plants were obtained by crossing target lines of 10 putative transcription factor genes from rice with six pattern lines showing expression in anther, stigma, palea, lemma and leaves. The EGFP and target genes perfectly co-expressed in hybrid plants with the same expression patterns as in the pattern lines. Various phenotypic changes, such as delayed flowering, multiple pistils, dwarfism, narrow and droopy leaves, reduced tillers, growth retardation and sterility, were induced as a result of the expression of the target genes. It is concluded that this transactivation system can provide a useful tool in rice to unveil latent functions of unknown or known genes.
Parameter Variation Tolerance and Error Resiliency: New Design Paradigm for the Nanoscale Era (2010)

Variations in process parameters affect the operation of integrated circuits (ICs) and pose a significant threat to the continued scaling of transistor dimensions. Such parameter variations, however, tend to affect logic and memory circuits in different ways. In logic, this fluctuation in device geometries might prevent them from meeting timing and power constraints and degrade the parametric yield. Memories, on the other hand, experience stability failures on account of such variations. Process limitations are not exhibited as physical disparities only; transistors experience temporal device degradation as well. Such issues are expected to further worsen with technology scaling. Resolving the problems of traditional Si-based technologies by employing non-Si alternatives may not present a viable solution; the non-Si miniature devices are expected to suffer the ill-effects of process/temporal variations as well. To circumvent these nonidealities, there is a need to design ICs that can adapt themselves to operate correctly under the presence of such inconsistencies. In this paper, we first provide an overview of the process variations and time-dependent degradation mechanisms. Next, we discuss the emerging paradigm of variation-tolerant adaptive design for both logic and memories. Interestingly, these resiliency techniques transcend several design abstraction levels-we present circuit and microarchitectural techniques to perform reliable computations in an unreliable environment.