gebhart/patrepeval huggingface dataset:
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics (2016)

The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as multiple host factors involved in endocytosis (RAB5C and RABGEF), heparin sulfation (NDST1 and EXT1), and transmembrane protein processing and maturation, including the endoplasmic reticulum membrane complex (EMC). We find that both flaviviruses require the EMC for their early stages of infection. Together, these studies generate a high-confidence, systems-wide view of human-flavivirus interactions and provide insights into the role of the EMC in flavivirus replication.
Nicotine and Attention in Aduit Attention Deficit Hyperactivity Disorder (ADHD)1 (1996)

Nicotine, like the psychostimulants methylphenidate and dextroamphetamine, acts as an indirect dopamine agonist and improves attention and arousal. Adults and adolescents with attention deficit hyperactivity disorder (ADHD) smoke much more frequently than normal individuals or those with other psychiatric con­ ditions, perhaps as a form of self-medication for ADHD symptoms. Nicotine might therefore have some value as a treatment for ADHD. The present study is an acute double-blind crossover administration of nicotine and placebo with smokers (n=6) and nonsmokers [n= 11) diagnosed with adult ADHD. The drug was delivered via a transdermal patch at a dosage of 7 mg/day for nonsmokers and 21 mg/day for smokers. Results indi­ cate significant clinician-rated global improvement, self-rated vigor and concentration, and improved per­ formance on chronometric measures of attention and timing accuracy. Side effects were minimal. These acute results indicate the need for a longer clinical trial and a comparison with other stimulants in adult ADHD treatment.
Comparative Cardiac Gene Delivery of Adeno‐Associated Virus Serotypes 1–9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart (2010)

Cardiac gene transfer is an attractive tool for developing novel heart disease treatments. Adeno-associated viral (AAV) vectors are widely used to mediate transgene expression in animal models and are being evaluated for human gene therapy. However, it is not clear which serotype displays the best cardiac tropism. Therefore, we curried out this study to directly compare AAV serotypes 1-9 heart transduction efficiency after indirect intracoronary injection. AAV-cytomegalovirus immediate early enhancer promoter (CMV)-luciferase serotypes 1-9 were injected in the left ventricular cavity of adult mice, after cross-clamping the ascending aorta and pulmonary artery. An imaging system was used to visualize luciferase expression at 3, 7, 21, 70, and 140 days postinjection. Echocardiography was performed to evaluate cardiac function on day 140. At the end of the study, luciferase enzyme activity and genome copies of the different AAV serotypes were assessed in several tissues and potential AAV immunogenicity was evaluated on heart sections by staining for macrophage and lymphocyte antigens. Among AAV serotypes 1-9, AAV6 showed the best capability of achieving high transduction levels in the myocardium in a tissue-specific manner, whereas the other serotypes had less cardiac transduction and more extracardiac expression, especially in the liver. Importantly, none of the serotypes tested with this marker gene affected cardiac function nor was associated with inflammation.
Effects of high levels of fatty acids on functional recovery of ischemic hearts from diabetic rats (2006)

In this study we determined the effects of high levels of fatty acids on recovery of heart function when present either during or after ischemia. Isolated working hearts from 6-wk streptozotocin diabetic and control rats perfused with 11 mM glucose were subjected to 25 min of global ischemia followed by 30 min of aerobic reperfusion. Four groups were studied: 1) 1.2 mM palmitate present before, during, and after ischemia; 2) 1.2 mM palmitate present before and during ischemia, followed by reperfusion in the absence of palmitate; 3) no palmitate before and during ischemia, followed by 1.2 mM palmitate during reperfusion; and 4) no palmitate before and during ischemia or during reperfusion. In control hearts, palmitate during reperfusion depressed recovery of function regardless of whether palmitate was present or absent during ischemia. In contrast, palmitate present during reperfusion did not depress recovery of mechanical function in the diabetic rat hearts. However, the presence of palmitate during ischemia itself in diabetic rat hearts was detrimental to recovery of mechanical function. The presence of palmitate during ischemia resulted in an accelerated rate of ATP loss and a decreased rate of lactate accumulation during ischemia, although this effect was similar in control and diabetic rat hearts. Our results demonstrate that high concentrations of fatty acids depress functional recovery of control rat hearts during the reperfusion period but depress recovery of function in diabetic rat hearts when present during ischemia itself.
P4‐300: New exploratory Alzheimer's drug anavex 2‐73 changes in electrophysiological markers in Alzheimer's disease: First patient data from an ongoing phase 2a study in mild‐to‐moderate Alzheimer's patients (2015)

Despite major efforts aimed at finding a treatment for Alzheimer's disease (AD), progress in developing compounds that can relieve cognitive deficits associated with the disease has been slow. ANAVEX 2-73 is a sigma-1 and muscarinic receptor agonist that in preclinical studies has shown memory-preserving and neuroprotective effects. In our ongoing phase 2a clinical study, we are using resting EEG and event related potentials (ERP) to assess cognitive effects and optimize dosing of ANAVEX 2-73 in subjects with mild-to-moderated AD. Thirty-two subjects between 55 and 85 years of age that meet NINCDS-ADRDA criteria for probable AD and have an MMSE of 16 to 28 are being recruited at up to seven clinical sites in Melbourne, Australia. Participants are administered ANAVEX 2-73 in combination with donepezil in an open-label, 2-period, cross-over, adaptive study design lasting up to 36 days for each participant. All subjects are administered an EEG/ERP test at baseline and during the 2 periods of drug administration. The testing protocol consists of a two-deviant auditory oddball paradigm followed by 3min of resting EEG. At the end of each test cognitive measures such as the N200, P3a and P3b components of the ERP wave, and the peak alpha frequency (PAF) of the resting EEG frequency spectrum are analyzed to assess ANAVEX 2-73 efficacy. Analysis of data from the first five subjects shows an increase in P3b amplitude after administration of ANAVEX 2-73. The effect is larger than the one reported in the scientific literature for donepezil, and suggests a significant improvement in short-term memory after treatment. Moreover, data collected so far show that ANAVEX 2-73 increases PAF, an EEG measure that is directly correlated with processing speed and with performance in a number of cognitive tasks. Preliminary results from the clinical trial show that the new exploratory Alzheimer's drug ANAVEX 2-73 can positively affect cognitive performance in subjects with mild-to-moderate AD. Data collected so far suggests that its cognitive enhancing effects might be superior to the current standard of care. A more complete set of results will be available at the time of the conference.
Surgical Treatment of Acute Manifestations of Crohn's Disease during Pregnancy (1997)

When requiring surgery, acute exacerbations of Crohn's disease in pregnancy have been reported to carry high maternal and fetal mortality. We report six cases. The women presented at 30, 28, 12, 11, 31 and 25 weeks' gestation and all proved to have intraperitoneal sepsis. In three, the acute symptoms were the first indication of Crohn's disease. All the women recovered and five had healthy babies; the other had a miscarriage when a colonic anastomosis dehisced. In pregnant women with Crohn's disease, the indications for surgery are the same as in non-pregnant patients. For acute manifestations we recommend removal of the source of the sepsis and exteriorization of the bowel ends.
Providing quality of service in always best connected networks (2003)

The next generation of mobile systems is expected to support multiple radio access technologies, as well as diverse types of terminals, including mobile phones, personal digital assistants, and laptops, as well as personal area, moving, and sensor networks. Thus, future wireless systems will not only continue to break technological barriers in terms of new air interface capabilities, higher bit rates, mobility, security, and QoS management, but will present new end-to-end scenarios in which applications access services over multiple L2 hops and multiple IP networks. The term always best connected refers to the concept of defining a set of access selection criteria and mechanisms that allow users to get connected to various services in a nearly optimal manner. Providing QoS in this type of heterogeneous multihop environment is a challenging task because applications may be completely unaware of them scenario and the underlying layer 2 technologies that can be quite different at different hops. For instance, some wireless links may have scarce resources and highly optimized QoS mechanisms; others may not support explicit QoS handling at all. In this article we consider the use of IP-level QoS signaling as a key component to support the end-to-end QoS for various applications. We propose a small set of application programmer- and wirelesslink-friendly IP QoS parameters (wireless hints) and illustrate the use of these in a specific WLAN-to-cellular handover situation. We conclude that the proposed model, signaling protocol, and wireless information elements can efficiently support QoS in heterogeneous mobile environments.
Modified root locus plots for SISO systems with time delay (1993)

The use of modified root locus plots in the assessment of the robustness of closed-loop systems with respect to phase lag is examined. It is suggested that the use of a pure time delay in series with the nominal open-loop transfer function provides a natural model of an important way in which modeling error arises. A modified root locus plot depicting the variation of closed-loop pole magnitudes and damping factors explicitly as a function of the time delay then provides a transparent means of assessing the effects of such modeling error.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
34‐2: <i>Distinguished Paper:</i> Development of 55inch 8K AMOLED TV by Inkjet Printing Process (2020)

In this paper, we presented 55 inch 8K4K AMOLED TV employing coplanar Oxide TFT backplane, top emissive inkjet‐printing OLED device, Gate Driver on Array(GOA) and compensation technologies. It is so far the largest prototype AMOLED TV fabricated by using inkjet printing process with 8K resolution. It shows the stunning display quality thanks to the high resolution and fast refresh frequency. It proves that the inkjet printing process is not only cost competitive but also can deliver premium display.
The Structure of Isomaltol<sup>1</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure of Isomaltol1B. E. Fisher and J. E. HodgeCite this: J. Org. Chem. 1964, 29, 4, 776–781Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/jo01027a002https://doi.org/10.1021/jo01027a002research-articleACS PublicationsRequest reuse permissionsArticle Views370Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene. (1981)

For the eventual purpose of isolating and studying a single animal cell replicon, we have developed a methotrexate-resistant Chinese hamster ovary cell line that has amplified an early-replicating DNA sequence approximately 500 times; this sequence includes the gene coding for dihydrofolate reductase (DHFR; tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). DHFR composes 30% of the cytoplasmic protein in this cell line, and DHFR mRNA represents 25% of the message translatable in vitro. After digestion of genomic DNA from resistant cells with restriction enzymes, a unique set of highly repetitive restriction fragments can be visualized on agarose gels by ethidium bromide staining. These bands are not present in digests of parental DNA. We estimate the total length of the unit repeated sequence to be 135 +/- 15 kilobase pairs. Regardless of the restriction enzyme utilized, a subset of these repetitive fragments hybridizes to radioactive DHFR cDNA. The homogeneously staining regions on mitotic chromosomes in which these amplified sequences are located are shown to be early-replicating, as are the highly repeated restriction fragments themselves. These data suggest that an early replicon can be isolated from this region, and that this entire, normally unique, genomic segment can be cloned and mapped with respect to origins of DNA synthesis and promoters for transcription, as well as other genetic features of interest.
Privacy Preserving Profiling for Mobile Services (2012)

The many sensors embedded in phones nowadays provide advanced sensing capabilities that make it possible to capture real-time information about the user and his surroundings. There are already examples of apps that use this information to provide highly useful and contextual services to the users. However, users are still reluctant to share their personal data with service providers due to their privacy implications (if misused). In this work, we provide protocols that allow users to store their sensor data on third party (untrusted) cloud servers. The data is stored in encrypted form (so protected from the cloud providers) with access only to service providers explicitly pre-approved by the users. The protocols simultaneously also ensure that the data accessed by service providers is in fact ‘current’ and consistent. This is achieved by integrating transactional and cryptographic primitives, such as atomic uploads, optimistic concurrency control, proxy re-encryption and homomorphic encryption, among others. Finally, experimental results are given to illustrate the practical feasibility and scalability of the proposed protocols.
A fast data collection and augmentation procedure for object recognition (2008)

When building an application that requires object class recognition, having enough data to learn from is critical for good performance, and can easily determine the success or failure of the system. However, it is typically extremely labor-intensive to collect data, as the process usually involves acquiring the image, then manual cropping and hand-labeling. Preparing large training sets for object recognition has already become one of the main bottlenecks for such emerging applications as mobile robotics and object recognition on the web. This paper focuses on a novel and practical solution to the dataset collection problem. Our method is based on using a green screen to rapidly collect example images; we then use a probabilistic model to rapidly synthesize a much larger training set that attempts to capture desired invariants in the object's foreground and background. We demonstrate this procedure on our own mobile robotics platform, where we achieve 135x savings in the time/effort needed to obtain a training set. Our data collection method is agnostic to the learning algorithm being used, and applies to any of a large class of standard object recognition methods. Given these results, we suggest that this method become a standard protocol for developing scalable object recognition systems.

Further, we used our data to build reliable classifiers that enabled our robot to visually recognize an object in an office environment, and thereby fetch an object from an office in response to a verbal request.
Properties of InSb Thin Films Grown by Molecular Beam Epitaxy and Their Applications to Magnetic Field Sensors (2003)

Recent developments in InSb thin film magnetic sensor technology were reviewed. Tin (Sn) doped InSb thin films grown on GaAs substrates by molecular beam epitaxy, showed high electron mobility and sheet resistance with very small temperature dependence. High sensitivity Hall elements and magnetoresistance elements were fabricated using Sn doped InSb thin films and their electrical and magnetic properties were investigated. The potential use of magnetic sensors for non-contact detection of linear motion, rotation and future energy saving in electric power systems was discussed.
Stress effects on gastrointestinal transit in the rat. (1989)

Previous investigations of stress effects on gastric emptying, orocaecal, and colonic transit in rats have produced conflicting results. Here one type of stressor, a 'passive avoidance' situation, was used to investigate its effects on gastric emptying, orocaecal and colonic transit. After the rats had been trained to eat a standard amount of semisolid food, gastric emptying was determined (n = 12) by the food remaining in the stomach after various periods of rest, or stress exposure. Orocaecal transit (n = 14) was determined by breath hydrogen measurements after the food had been labelled with 1 g lactose. Colonic transit (n = 18) was measured as the arrival time of coloured faeces after infusion of a carmine red solution into the caecum through a chronically implanted catheter. The stressor had differential effects on transit through the stomach, small bowel and colon: gastric emptying was delayed (p less than 0.05) after stress (t1/2 = 2.66 h after stress, 1.97 h at rest). Orocaecal transit was accelerated (p less than 0.05) after stress; transit time decreased from 124.3 min at rest to 86.2 min after stress. Colonic transit was accelerated (p less than 0.01) under stress, from 15.5 h to 1.29 h. It is concluded that gastrointestinal transit in different parts of the gastrointestinal tract is differently affected by central nervous stimuli.
A watermarking technique to secure printed QR codes using a statistical test (2017)

The QR (Quick Response) code is a two-dimensional barcode, which was designed for storage information and high-speed reading applications. Being cheap to produce and fast to read, it becomes actually a popular solution for product labeling. Ones try to make QR code a solution against counterfeiting. In this paper, we present a novel technique that permits to create a secure printed QR code which is robust against Scan & Reprint attack. The code is constructed by replacing the background of the standard one by a specific textured pattern which does not affect the normal reading of the encoded message. Scan & Reprint attacks lead to the degradation of the texture and change its statistical characteristics, which can be detected thanks to a statistical hypothesis testing. The experimental results show a good performance of the proposed solution.
Monolithic 40 Gbps Separate Absorption and Modulation Mach-Zehnder Wavelength Converter (2007)

The first 40 Gbps monolithic SAM Mach-Zehnder wavelength converter is demostrated. The device exhibits a bandwidth in excess of 20 GHz and power penalties less than 2.5 dB at 40 Gbps using NRZ data.
Focusing commercial sponsorship on the internal corporate audience (1998)

Sponsorship is an effective means of communicating with corporate audiences, both external and internal (i.e. the sponsor's own workforce). This paper gives a case history of how the Bank of Ireland merchandised to staff its sports sponsorship programme. Research showed how the staff viewed their employer's activities.
Linear superposition of sensory-evoked and ongoing cortical hemodynamics (2010)

Modern non-invasive brain imaging techniques utilize changes in cerebral blood flow, volume and oxygenation that accompany brain activation. However, stimulus-evoked hemodynamic responses display considerable inter-trial variability even when identical stimuli are presented and the sources of this variability are poorly understood. One of the sources of this response variation could be ongoing spontaneous hemodynamic fluctuations. To investigate this issue, 2-dimensional optical imaging spectroscopy was used to measure cortical hemodynamics in response to sensory stimuli in anesthetized rodents. Pre-stimulus cortical hemodynamics displayed spontaneous periodic fluctuations and as such, data from individual stimulus presentation trials were assigned to one of four groups depending on the phase angle of pre-stimulus hemodynamic fluctuations and averaged. This analysis revealed that sensory evoked cortical hemodynamics displayed distinctive response characteristics and magnitudes depending on the phase angle of ongoing fluctuations at stimulus onset. To investigate the origin of this phenomenon, "null-trials" were collected without stimulus presentation. Subtraction of phase averaged "null trials" from their phase averaged stimulus-evoked counterparts resulted in four similar time series that resembled the mean stimulus-evoked response. These analyses suggest that linear superposition of evoked and ongoing cortical hemodynamic changes may be a property of the structure of inter-trial variability.
Effective Medium Theory of Left-Handed Materials (2004)

We analyze the transmission and reflection data obtained through transfer matrix calculations on metamaterials of finite lengths, to determine their effective permittivity epsilon and permeability micro. Our study concerns metamaterial structures composed of periodic arrangements of wires, cut wires, split ring resonators (SRRs), closed SRRs, and both wires and SRRs. We find that the SRRs have a strong electric response, equivalent to that of cut wires, which dominates the behavior of left-handed materials (LHM). Analytical expressions for the effective parameters of the different structures are given, which can be used to explain the transmission characteristics of LHMs. Of particular relevance is the criterion introduced by our studies to identify if an experimental transmission peak is left or right handed.