gebhart/patrepeval huggingface dataset:
Ballooned neurons in several neurodegenerative diseases and stroke contain αB crystallin (1992)

alpha B crystallin is a protein which has homology with the small cell stress proteins. A characterized antibody to residues 1-10 of alpha B crystallin was used to immunostain tissues containing ballooned (chromatolytic, achromasic) neurons. The tissues included two cases of classical Pick's disease, one case of dementia with swollen achromasic neurons in the cortex, two cases of Alzheimer's disease with large numbers of ballooned neurons, two cases of motor neuron disease, four cases of cortico-basal degeneration, and four cases with areas of brain showing swollen neurons adjacent to recent cerebral infarcts. The anti-alpha B crystallin showed strong diffuse cytoplasmic immunoreactivity of swollen cortical neurons in all the diseases. Astrocytes and oligodendroglial cells were also stained in normal tissues as previously described. Weak diffuse immunoreactivity with an antibody to ubiquitin-conjugates was also seen in the swollen neurons from cases of neurodegenerative disease but not following infarction. Ballooned neurons have been shown to contain phosphorylated neurofilament epitopes not normally present in the perikaryonal region. The presence of alpha B crystallin in ballooned neurons, together with previous data which also indicate its close association with intermediate filaments, suggest that alpha B crystallin may be involved in aggregation and remodelling of neurofilaments in disease. The presence of alpha B crystallin in neurons at the edge of areas of cerebral infarction is likely to reflect cells which are regenerating following damage; its detection may therefore be a marker for such cells. On a practical level, the antibody greatly facilitates the localization of such abnormal neurons in diagnostic histology.
Preamble-less demodulator for Inmarsat standard-C coast earth station (2003)

The authors propose a new preambleless demodulator method for mobile satellite communications systems. It was realized by a switch-back method with real-time processing carrier recovery to track carrier variations caused by multipath fading and carrier frequency changes. The ACE-DEMO concept, which is carrier recovery using an adaptive filtering technique, was employed because of its wide pull-in frequency range. A preambleless demodulator for the Inmarsat standard-C signaling channel using the proposed method was developed. In the performance evaluation, the first generation preambleless demodulator satisfied the 2.2% burst error probability for the 4.7-dB E/sub b//N/sub 0/, 7-dB carrier-power-to-multipath-power ratio multipath fading, and 65-Hz/s carrier frequency change environments to satisfy the Inmarsat standard-C specification.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Scheduling threads for constructive cache sharing on CMPs (2007)

In chip multiprocessors (CMPs), limiting the number of offchip cache misses is crucial for good performance. Many multithreaded programs provide opportunities for constructive cache sharing, in which concurrently scheduled threads share a largely overlapping working set. In this paper, we compare the performance of two state-of-the-art schedulers proposed for fine-grained multithreaded programs: Parallel Depth First (PDF), which is specifically designed for constructive cache sharing, and Work Stealing (WS), which is a more traditional design. Our experimental results indicate that PDF scheduling yields a 1.3--1.6X performance improvement relative to WS for several fine-grain parallel benchmarks on projected future CMP configurations; we also report several issues that may limit the advantage of PDF in certain applications. These results also indicate that PDF more effectively utilizes off-chip bandwidth, making it possible to trade-off on-chip cache for a larger number of cores. Moreover, we find that task granularity plays a key role in cache performance. Therefore, we present an automatic approach for selecting effective grain sizes, based on a new working set profiling algorithm that is an order of magnitude faster than previous approaches. This is the first paper demonstrating the effectiveness of PDF on real benchmarks, providing a direct comparison between PDF and WS, revealing the limiting factors for PDF in practice, and presenting an approach for overcoming these factors.
<title>Building solid models from serial contour images</title> (1995)

To create solid models of irregularly shaped objects, a mesh of curves consisting of two orthogonal sets of planar contours that define both transverse and longitudinal cross sections is usually required. By interpolating the in-slice contour-point list one can fairly easily obtain one set of such planar contours, but the question arises of how to produce the other orthogonal set of contours. In the approach reported here, the object contour data in slice images are first processed by an optimal triangulation algorithm of a surface modeler, and the output triangles are used as the initial guess of possible inter-slice point matches. Local contour features are computed and the prominent points of each 2D contour line are identified and classified (e.g. local curvature maxima or inflections). This information will guide our optimal vertical path search algorithm, and in the searching process the dominant points are given priorities for possible connections. This approach aims at retaining structures with rotational displacement, which are commonly seen in bone anatomy. A 2D bicubic spline interpolation is then employed to produce an isotropic mesh of curves. From the mesh of curves so obtained, an isotropic three dimensional (3D) bone object is created by an automatic filling and labeling algorithm developed by the author to permit volume rendering. Initial results of the visualization of bone solid models have been encouraging using AVS (Advanced Visual Systems Inc., Waltham, MA) as well as our own GUI. The results also showed advantages of our system over surface modeling techniques when used to visualize certain geometrical properties with fine resolution, such as proximity map, and to make more accurate volume and distance measurements.
Regions of Human Immunodeficiency Virus Type 1 <i>nef</i> Required for Function In Vivo (1998)

In vivo studies in monkeys and humans have indicated that immunodeficiency viruses with Nef deleted are nonpathogenic in immunocompetent hosts, and this has motivated a search for live attenuated vaccine candidates. However, the mechanisms of action of Nef remain elusive. To define the regions of human immunodeficiency virus type 1 (HIV-1) Nef which mediate in vivo pathogenicity, a series of mutated isogenic viruses were inoculated into human thymic implants in SCID-hu mice. Mutation of several regions, including the myristoylation site at the second glycine and a region encompassing amino acids 41 through 49 of Nef, profoundly affected pathogenicity. Surprisingly, mutations of prolines in either of the two distant PXXP SH3 binding domains did not affect pathogenicity, indicating that these regions are not required for Nef activity in developing T-lineage cells. These data suggest that some functions of Nef described in vitro may not be relevant for in vivo pathogenicity.
A Fully Integrated Quad-Band GSM/GPRS CMOS Power Amplifier (2008)

The presented PA proves the viability of CMOS technology for watt-level fully integrated power generation for wireless applications and serves as another step toward a single-chip cell-phone.
<u>Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface of lung pulmonary endothelial cells</u> (1995)

Conference Article| May 01 1995 Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface of lung pulmonary endothelial cells ISABELLE MAHIEU; ISABELLE MAHIEU 1Medical Genetics Unit, St George's Hospital Medical School, London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar AUDRA BENJAMIN; AUDRA BENJAMIN 2Department of Child Health, St George's Hospital Medical School, London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar RICHARD STEPHENS; RICHARD STEPHENS 2Department of Child Health, St George's Hospital Medical School, London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar DAFYDD WALTERS; DAFYDD WALTERS 2Department of Child Health, St George's Hospital Medical School, London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar NICK CARTER NICK CARTER 1Medical Genetics Unit, St George's Hospital Medical School, London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (2): 320S. https://doi.org/10.1042/bst023320s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation ISABELLE MAHIEU, AUDRA BENJAMIN, RICHARD STEPHENS, DAFYDD WALTERS, NICK CARTER; Characterization of membrane bound carbonic anhydrase IV (CA IV) located on the external surface of lung pulmonary endothelial cells. Biochem Soc Trans 1 May 1995; 23 (2): 320S. doi: https://doi.org/10.1042/bst023320s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Changes of chromatin condensation in one patient with ataxia telangiectasia disorder: A structural study (1999)

Differential scanning calorimetry and quantitative fluorescence microscopy have been employed to characterize the structure and organization of in situ chromatin in lymphoblastoid cells obtained from one ataxia telangiectasia (A-T) patient and one healthy family member. The proven capability of these biophysical techniques to measure changes of chromatin condensation directly inside the cells makes them very powerful in studying the eventual structural changes associated with the appearance of a pleiotropic genetic disorder such as ataxia telangiectasia. A-T syndrome is genetically heterogeneous and can be induced by different mutations of a single gene. The aim of this work is to determine whether the genetic mutation exhibited by the A-T patient of this study may be associated with modifications of chromatin structure and organization. Both the calorimetric and the fluorescence microscopy results acquired on cells from the A-T patient show that the structure and distribution of nuclear chromatin in situ change considerably with respect to the control. A significant decondensation of the nuclear chromatin is in fact associated with the appearance of the A-T disorder in the A-T patient under analysis, together with a rearrangement of the chromatin domains inside the nucleus.
Security services in telecommunications networks (2003)

The issues that are relevant to computer security and communications security are reviewed, including security architecture and cryptography. Possible solutions for security management functions that are compatible with present and future telecommunications networks standardized by CCITT are described. European cooperation is briefly considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Photophysics of BODIPY Dyes as Readily-Designable Photosensitisers in Light-Driven Proton Reduction (2017)

A series of boron dipyrromethene (BODIPY) dyes was tested as photosensitisers for light-driven hydrogen evolution in combination with the complex [Pd(PPh3)Cl2]2 as a source for catalytically-active Pd nanoparticles and triethylamine as a sacrificial electron donor. In line with earlier reports, halogenated dyes showed significantly higher hydrogen production activity. All BODIPYs were fully characterised using stationary absorption and emission spectroscopy. Time-resolved spectroscopic investigations on meso-mesityl substituted compounds revealed that reduction of the photo-excited BODIPY by the sacrificial agent occurs from an excited singlet state, while, in halogenated species, long-lived triplet states are present, determining electron transfer processes from the sacrificial agent. Quantum chemical calculations performed at the time-dependent density functional level of theory indicate that the differences in the photocatalytic performance of the present series of dyes can be correlated to the varying efficiency of intersystem crossing in non-halogenated and halogenated species and not to alterations in the energy levels introduced upon substitution.
Precise pose graph localization with sparse point and lane features (2017)

We introduce a novel pose graph-based localization technique for autonomous driving that incorporates both sparse point features as well as lane markings on the road. Unlike many commonly used filter methods, our graph-based localization takes a much larger history of the trajectory into account. In addition, we utilize a multiple-hypothesis approach for data association for increased robustness against the presence of outliers. By incorporating both sparse point features and lane markings, we are able to take advantage of both kinds of features widely available in urban environments as well as highways. Furthermore, by using high level features, we avoid having to store and match against large amounts of data such as dense 3D point clouds. Finally, we evaluate our approach on real driving sequences on city roads.
Insulin-Dependent Leptin Expression in Breast Cancer Cells (2008)

Pathologic conditions associated with hyperinsulinemia, such as obesity, metabolic syndrome, and diabetes, seem to increase the risk of breast cancer. Here, we studied molecular mechanisms by which insulin activates the expression of leptin, an obesity hormone that has been shown to promote breast cancer progression in an autocrine or paracrine way. Using MDA-MB-231 breast cancer cells, we found that (a) insulin stimulated leptin mRNA and protein expression, which was associated with increased activation of the leptin gene promoter; (b) insulin increased nuclear accumulation of transcription factors hypoxia inducible factor (HIF)-1alpha and Sp1 and their loading on the leptin promoter; (c) small interfering RNA (siRNA)-mediated knockdown of either HIF-1alpha or Sp1 significantly down-regulated insulin-induced leptin mRNA and protein expression; further inhibition of leptin expression was observed under the combined HIF-1alpha and Sp1 siRNA treatment; (d) inhibition of extracellular signal-regulated kinase (ERK)1/2 and phosphatidylinositol-3-OH kinase (PI-3K) pathways significantly, albeit partially, decreased insulin-dependent leptin mRNA and protein expression, which coincided with reduced association of HIF-1alpha and/or Sp1 with specific leptin promoter regions; and (e) inhibition of ERK1/2 reduced recruitment of both HIF-1alpha and Sp1 to the leptin promoter, whereas down-regulation of PI-3K influenced only HIF-1alpha binding. In summary, our data suggest that hyperinsulinemia could induce breast cancer progression through leptin-dependent mechanisms. In MDA-MB-231 cells, this process requires Sp1- and HIF-1alpha-mediated leptin gene transcription and is partially regulated by the PI-3K and ERK1/2 pathways.
Allogeneic hematopoietic stem cell transplantation in a patient with HIV-negative recurrent plasmablastic lymphoma (2021)

The survival of recurrent PBL after autologous hematopoietic stem cell transplantation is very poor. Salvage allogeneic hematopoietic stem cell transplantation may bring long-term survival opportunities for those patients. Further clinical studies are needed to explore the role of allogeneic hematopoietic stem cell transplantation in refractory and recurrent PBL.
OCS Leasing and Auctions: Incentives and the Performance of Alternative Bidding Institutions (1983)

In Watt v. Energy Action Educational Foundation, the Supreme Court rebutted a challenge to the federal government's mix of "nontraditional" outer continental shelf lease-auction mechanisms authorized under the 1978 OCS Amendments. The issues of this case addressed here include: the economic intent of the congressional language; incentive properties of various of the authorized auction processes; methodological shortcomings inherent in the implicit congressional directive for field experimentation; and, the usefulness of laboratory experimental economics in answering relevant auction-policy questions. The discussion of experimental economics includes evidence already gained from laboratory experiments relating to hypotheses about auction-market performance.
Kinetics of the coupling reactions of the nitroxyl radical 1,1,3,3-tetramethylisoindoline-2-oxyl with carbon-centered radicals (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the coupling reactions of the nitroxyl radical 1,1,3,3-tetramethylisoindoline-2-oxyl with carbon-centered radicalsAthelstan L. J. Beckwith, Vincent W. Bowry, and Graeme MoadCite this: J. Org. Chem. 1988, 53, 8, 1632–1641Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/jo00243a008https://doi.org/10.1021/jo00243a008research-articleACS PublicationsRequest reuse permissionsArticle Views1051Altmetric-Citations130LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ontology Graph Based Query Expansion for Biomedical Information Retrieval (2011)

Query expansion based biomedical information retrieval has been studied for over two decades; most of the studies focus only on taking advantage of one vocabulary: MeSH. We propose a completely different approach utilizing an arbitrary number of controlled vocabularies from Metathesaurus. Experiment shows that our ontology based query expansion scheme achieves 8.2% and 17.7% improvement compared with schemes using pseudo relevance feedback query expansion and using no query expansion respectively. The average improvement is 24.8% in comparison to all other existing strategies. Furthermore, we identify that generalized biomedical concepts are the reason for performance degradation.
SMT-based scheduling for multiprocessor real-time systems (2016)

Real-time system is playing an important role in our society. For such a system, sensitivity to timing is the central feature of system behaviors, which means tasks in the system are required to be completed before their deadlines. Currently, almost all the practical real-time systems are equipped within multiple processors, for which the schedule synthesis to make sure that all the tasks can be completed before their deadlines is known to be an NP complete problem. In this paper, to solve the scheduling problem, we propose a scheduling method based on satisfiability modulo theories (SMT). In the method, the problem of scheduling is treated as a satisfiability problem. The key work is to formalize the satisfiability problem using first-order language. After the formalization, a SMT solver (e.g., Z3, Yices) is employed to solve such a satisfiability problem. An optimal schedule can be generated based on a solution model returned by the SMT solver. Moreover, in the SMT-based scheduling method, we define the scheduling constraints as system constraints and target constraints. Such design makes the proposed method apply more widely compared with existing methods.
Iron and colorectal cancer: evidence from in vitro and animal studies (2015)

Iron is a vital trace element essential for mammalian life. It is involved in numerous biological and cellular processes such as oxygen transport, oxidative phosphorylation, and DNA synthesis, as well as cell cycle progression and growth. Normal and neoplastic cells have similar qualitative requirements for iron. In addition, research shows that iron promotes cancer cell growth. An adequate balance of iron is, therefore, critical for health. In states of iron deficiency, anemia can develop, whereas iron excess increases oxidative stress in body tissues, leading to lipid, protein, and DNA damage via the Fenton reaction, which results in the synthesis of hydroxyl radicals and other oxidants. It is thought that some of these processes are implicated in the pathogenesis of colorectal cancer. This review provides the clinician with an up-to-date summary of the recent advances in this field using established in vitro and animal models.
Photochemical Genetics. II. The Kinetic Role of Water in the Photohydration of Uracil and 1,3-Dimethyluracil (1968)

The rate of photohydration of uracil with light of 265 n.m. in mixtures of acetonitrile and water is a linear function of the water content of the mixture; the deuterium isotope effect, RH2O/RD2O, is 1.18. These observations are shown to be consistent with the mechanism for uracil photohydrate formation proposed to explain the pH dependence of the rates. The rate of photohydrate formation for 1,3-dimethyuracil is approximately proportional to the square of the water concentration in acetonitrile-H2O mixtures, acetonitrile-D2O, and in dioxane-water mixtures, RH2o/RD2o = 2.84. These data are also interpretable in terms of a common photohydration mechanism.
Studies on Chitin from the Standpoints of Polymer Chemistry (1958)

キチンを水溶性誘導体に変える一つの方法としてそのCM化を試み目的を達することができた.そこで一般多糖類のCM化にも適用できるような合理的な反応条件を確立する目的で,キチンに分散(均一)状態でClAcONaを作用させ, CM化の模様を動力学的に研究し,それをClAcONaの苛性ソーダによる分解反応のそれと比較考察した.その結果,均一系でのCM化には次のような反応条件が適当であることを実証した. (1) 苛性ソーダ濃度はCM化に最も大きい影響を及ぼし,その影響はClAcONaの分解に及ぼすそれよりも顕著である.従ってその濃度は反応系が不均一にならない限りではできるだけ濃い方が良く,約15%位が適当である. (2) CM化の活性化エネルギーは22.4Calで, ClAcONaの分解反応のそれと全く一致する.従って温度を調節してClAcONaの分解のみをおさえることは不可能で,反応時間を短縮する意味では温度はできるだけ高くする方が良い. (3) CM化の反応速度はClAcONaの分解速度の約20倍で,極めて急速である. なお,以上の事柄は苛性ソーダ濃度が濃い(約20%)か或いは温度が高くて(約30°),反応系が不均一になるとそのままでは適用できない.このようにして得られるCMCはキチンの第2級水酸基のみが選択的にCM化されると同時にそのアミノアセチル基が鹸化されたものと考えられ,同じ分子内にカルボキシル基とアミノ基とを併有する両性高分子電解質である.