gebhart/patrepeval huggingface dataset:
Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities (2012)

Triple-negative breast cancer (TNBC) is characterized by the absence of expression of estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after first-line treatment, and metastatic TNBC (mTNBC) has a poor prognosis with median survival of one year. Here, we present initial analyses of whole genome and transcriptome sequencing data from 14 prospective mTNBC. We have cataloged the collection of somatic genomic alterations in these advanced tumors, particularly those that may inform targeted therapies. Genes mutated in multiple tumors included TP53, LRP1B, HERC1, CDH5, RB1, and NF1. Notable genes involved in focal structural events were CTNNA1, PTEN, FBXW7, BRCA2, WT1, FGFR1, KRAS, HRAS, ARAF, BRAF, and PGCP. Homozygous deletion of CTNNA1 was detected in 2 of 6 African Americans. RNA sequencing revealed consistent overexpression of the FOXM1 gene when tumor gene expression was compared with nonmalignant breast samples. Using an outlier analysis of gene expression comparing one cancer with all the others, we detected expression patterns unique to each patient's tumor. Integrative DNA/RNA analysis provided evidence for deregulation of mutated genes, including the monoallelic expression of TP53 mutations. Finally, molecular alterations in several cancers supported targeted therapeutic intervention on clinical trials with known inhibitors, particularly for alterations in the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. In conclusion, whole genome and transcriptome profiling of mTNBC have provided insights into somatic events occurring in this difficult to treat cancer. These genomic data have guided patients to investigational treatment trials and provide hypotheses for future trials in this irremediable cancer.
Augmented Reality Interface for Electronic Music Performance (2001)

Starting from the days of the Musical Telegraph, the first electronic instrument, the majority of synthesizers today are still equipped with keyboards, often using the traditional layout of acoustic pianos. The question that many researchers attempt to answer is that of improvement. In this paper we present an Augmented Groove, a novel musical instrument that attempts to depart from traditional approaches to musical performance, i.e. use keyboards, dials or simulated traditional musical controllers. It allows novices to play electronic musical compositions, interactively remixing and modulating their elements, by manipulating simple physical objects. 1.
EXPERIMENTAL GLOMERULONEPHRITIS IN MICE AS A MODEL FOR IMMUNOPHARMACOLOGICAL STUDIES (1982)

The experimental glomerulonephritis was caused by the intravenous injection of a subnephrotoxic dose of nephrotoxic serum in the mice which had been previously immunized with rabbit IgG and complete Freund’s adjuvant. The elevation of urinary protein excretion, serum blood urea nitrogen level and cholesterol level and the decrease of serum albumin level were demonstrated in nephritic mice. Hypercellularity in the glomerulus and hyalinosis in tubular system were observed in histopathological studies. The clinical signs in this experimental model were similar to human glomerulonephritis. In a transfer experiment, sensitized lymphocytes against rabbit IgG were necessary for the onset of disease. Clear remission of glomerulonephritis was indicated by the administration of cyclophosphamide or 6-mercaptopurine. Glucocorticoids showed moderate suppression of the development of this nephritis. These evidences suggest that this experimental model is useful for the immunopharmacological research of glomerulonephritis.
RF and Microwave Transistor Oscillator Design (2007)

About the Author. Preface. Acknowledgements. 1 Nonlinear circuit design methods. 1.1 Spectral-domain analysis. 1.2 Time-domain analysis. 1.3 Newton-Raphson algorithm. 1.4 Quasilinear method. 1.5 Van der Pol method. 1.6 Computer-aided analysis and design. References. 2 Oscillator operation and design principles. 2.1 Steady-state operation mode. 2.2 Start-up conditions. 2.3 Oscillator configurations and historical aspects. 2.4 Self-bias condition. 2.5 Oscillator analysis using matrix techniques. 2.6 Dual transistor oscillators. 2.7 Transmission-line oscillator. 2.8 Push-push oscillator. 2.9 Triple-push oscillator. 2.10 Oscillator with delay line. References. 3 Stability of self-oscillations. 3.1 Negative-resistance oscillator circuits. 3.2 General single-frequency stability condition. 3.3 Single-resonant circuit oscillators. 3.4 Double-resonant circuit oscillator. 3.5 Stability of multi-resonant circuits. 3.6 Phase plane method. 3.7 Nyquist stability criterion. 3.8 Start-up and stability. References. 4 Optimum design and circuit technique. 4.1 Empirical optimum design approach. 4.2 Analytic optimum design approach. 4.3 Parallel feedback oscillators. 4.4 Series feedback bipolar oscillators. 4.5 Series feedback MESFET oscillators. 4.6 High-efficiency design technique. 4.7 Practical oscillator schematics. References. 5 Noise in oscillators. 5.1 Noise figure. 5.2 Flicker noise. 5.3 Active device noise modelling. 5.4 Oscillator noise spectrum: linear model. 5.5 Oscillator noise spectrum: nonlinear model. 5.6 Loaded quality factor. 5.7 Amplitude-to-phase conversion. 5.8 Oscillator pulling figure. References. 6 Varactor and oscillator frequency tuning. 6.1 Varactor modelling. 6.2 Varactor nonlinearity. 6.3 Frequency modulation. 6.4 Anti-series varactor pair. 6.5 Tuning linearity. 6.6 Reactance compensation technique. 6.7 Practical VCO schematics. References. 7 CMOS voltage-controlled oscillators. 7.1 MOS varactor. 7.2 Phase noise. 7.3 Flicker noise. 7.4 Tank inductor. 7.5 Circuit design concepts and technique. 7.6 Implementation technology issues. 7.7 Practical schematics of CMOS VCOs. References. 8 Wideband voltage-controlled oscillators. 8.1 Main requirements. 8.2 Single-resonant circuits with lumped elements. 8.3 Double-resonant circuit with lumped elements. 8.4 Transmission line circuit realization. 8.5 VCO circuit design aspects. 8.6 Wideband nonlinear design. 8.7 Dual mode varactor tuning. 8.8 Practical RF and microwave wideband VCOs. References. 9 Noise reduction techniques. 9.1 Resonant circuit design technique. 9.2 Low-frequency loading and feedback optimization. 9.3 Filtering technique. 9.4 Noise-shifting technique. 9.5 Impedance noise matching. 9.6 Nonlinear feedback loop noise suppression. References. Index.
Morphological study on the changes in the kidney of the water-deprived Mongolian gerbil(Meriones unguiculatus) (1997)

Mongolian gerbil (Meriones unguiculatus) has been as an animal model for studing the neurological diseases such as stroke and epilepsy because of the congenital incompleteries in Willis circle, as well as the investigation of water metabolism because of the long time-survival in the condition of water-deprived desert condition, compared with other species animals. In order to accomplish the this research, first of all another divided the laboratory animals 5 groups of which each group include the 5 animals. In this study were investigated the histological structure in the kidney, measured the plasma osmolalities at the time of sacrifice of indivisual animals, and the body weights every day during water-deprived. The results obtained in this study were summarized as followings: 1. The body weights and decreasing rates of the body weight in water-deprived mongolian gerbil groups were continuosly decreased. 2. The plasma osmolalities were increased from the 5th water-deprived day, after then the gradually increasing reached nearly its equilibrium state at the 10th water-deprived day. 3. The urine volumes were abruptly decreased from the 2th water-deprived day, after then the gradually decreasing patterns were reached nearly its equilibrium state at the 10th day, and stopped the 11th day. 4. In the light microscopical observation of the kidney, glomerular capillary loop thickening, mesangial matrix increasing, sclerosis, glomerular cystic atrophy, interstitial fibrosis, tubular dilatation, mononuclear interstitial inflammation, interstitial mineralization, and hyperplasia of the collecting duct epithelium in the cortex area, were observed from the 10th water deprived day, and the lesions were gradually severe changed as the time lapse. 5. In the electron microscopical findings of the kidney, the degenerative changes of endothelial cell, podocyte and mesangial cell in glomeruli were initially observed on the 10th water-deprived day as well as the degeneration of microvilli and intracellular organelle in the renal tubules.
High-Gain Yagi-Uda Antennas for Millimeter-Wave Switched-Beam Systems (2009)

A high-efficiency microstrip-fed Yagi-Uda antenna has been developed for millimeter-wave applications. The antenna is built on both sides of a Teflon substrate (epsiv <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</sub> = 2.2) which results in an integrated balun for the feed dipole. A 7-element design results in a measured gain of 9-11 dB at 22-26 GHz with a cross-polarization level of < - 16 dB. The antenna is matched to 50 Omega (microstrip feed). A mutual coupling of < - 20 dB is measured between two Yagi-Uda antennas with a center-to center spacing of 8.75 mm (0.7 lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> at 24 GHz), and a two-element array results in a measured gain of 11.5-13 dB at 22-25 GHz. The planar Yagi-Uda antenna results in high radiation efficiency ( > 90 % ) and is suitable for mm-wave radars and high data-rate communication systems.
Intramolecular reaction between nitro and carbodi-imide groups; a new synthesis of 2-arylbenzotriazoles (1985)

1-(2-Nitrophenyl)-5-phenyltetrazole (5b) decomposes when heated to give nitrogen, carbon dioxide, and 2-phenylbenzotriazole (6) in high yield. This new molecular rearrangement proceeds via 2-nitrophenyl(phenyl)carbodi-imide (8). Other precursors of this carbodi-imide, i.e. oxadiazolone (10), oxadiazolethione (11), oxathiadiazole 2-oxide (12), and the aminimide (16), and carbodi-imide itself, all give 2-phenylbenzotriazole (6) on thermolysis, the last three in high yield. This reaction is general for diarylcarbodi-imides with an ortho nitro group, and their precursors, and it provides a useful new route to 2-arylbenzotriazoles. A sequence of electrocyclic ring closing and opening reactions (Scheme 5) is proposed as the mechanism of this process. The key intermediate, 2-phenyl-1,2,4-benzotriazin-3-one 1-oxide (19), has been isolated from a careful thermolysis of (12) in toluene; in solution it is in reversible equilibrium with the ring-opened form (20). This new nitro-carbodi-imide group interaction has been extended to the more stable nitrobiphenyl(phenyl)carbodi-imide (25) and nitronaphthyl(phenyl)-carbodi-imide (24) which, on flash vacuum pyrolysis, give benzimidazo[1,2-f]phenanthridine (29) and benz[cd]indazole 1-oxide (32) respectively, in new rearrangements.
The Management of Patients with Intradural Post-Traumatic Mass Lesions: A Multicenter Survey of Current Approaches to Surgical Management in 729 Patients Coordinated by the European Brain Injury Consortium (2005)

The results provide a contemporary picture of neurosurgical surgical approaches to the management of head injured patients with an intradural mass lesion and/or signs of raised intracranial pressure in some Neurosurgical Units across the world. The relative benefits of early versus delayed surgery in patients with intraparenchymal lesions and on the indications, technique and benefits of decompressive craniectomy could be topics for future head injury research.
Dynamic queries for visual information seeking (1994)

Considers how dynamic queries allow users to "fly through" databases by adjusting widgets and viewing the animated results. In studies, users reacted to this approach with an enthusiasm more commonly associated with video games. Adoption requires research into retrieval and display algorithms and user-interface design. The author discusses how experts may benefit from visual interfaces because they will be able to formulate more complex queries and interpret intricate results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Enhancement of amyloid induction by amyloid fibril fragments in hamster. (1987)

An extract (fibril amyloid-enhancing factor) prepared by sonication of a suspension of water-purified hamster AA-amyloid fibrils showed an amyloid-enhancing effect upon intraperitoneal injection into hamsters. The fibril amyloid-enhancing factor was identical to the original fibrils according to the results of infrared spectroscopy, gel filtration, gel electrophoresis, and Western blotting; although lyophilized samples of the extract did not show any green birefringence after staining with Congo red. From these results, it was concluded that fibril amyloid-enhancing factor represents small fragments of amyloid fibrils which enhance in vivo formation of amyloid fibrils.
Charge control model of inverted GaAs–AlGaAs modulation doped FET’s (IMODFET’s) (1984)

Current–voltage characteristics of an inverted GaAs–AlGaAs modulation doped transistor are calculated using a charge control model. Our calculations show that the electron concentration of the two dimensional electron gas for the inverted structure is comparable to those obtained in normal MODFET’s. The optimum design of an inverted device calls for a doped AlGaAs layer thin enough to be fully depleted. The sheet carrier concentration of the two dimensional electron gas will be only slightly less than the maximum possible. For such devices the predicted transconductances are close to those for normal modulation doped transistors.
Theoretical Logic Research on the Protection of the Rights and Interests of University Students in Combination of Work and Study (2020)

At this stage, most colleges and universities (especially higher vocational) personnel training require students to complete the engineering process in the form of “internship”. The combination of work and study involves students’ work time, work environment, work salary, work overtime, etc. This is bound to cause relevant The discussion of the labor rights of engineering students and the risk of labor rights and education rights being violated. According to the frontier legal theory, social law is positioned as a “third jurisdiction” and aims to favor the protection of vulnerable groups. In other words, examining the content of the legal relationship between work and study from the perspective of social law not only accords with the cutting-edge legal theory, but also provides a new perspective for the interpretation of work and study, and provides a new perspective for the integration of industry and education and the protection of student rights in the production management may.
Studies on Nilvadipine. III. Syntheses of Metabolites of Nilvadipine and Their Related Compounds. (1992)

Nilvadipine (I), isopropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-5-carboxylate, has a unique 1, 4-dihydropyridine structure in that the substituents at all five positions of the nucleus differ from one another. It is an excellent calcium antagonist drug in terms of its potency, its duration of action and its selectivity in the blood vascular system.During the development of I, some metabolites were isolated from the urine and bile of both rats and dogs afteroral administration. With data obtained from the metabolism of known 1, 4-dihydropyridines at hand, we proposed the synthesis of a series of compounds (1-11) for comparison with the metabolites isolated from I as a method for structure determination. Indeed, of the compounds synthesized five of them (3-7) were found to coincide with the metabolites from both rat and dog urine and bile isolates.
Optical disc inspection by linear array CCD systems (2002)

AID Inc. has played an active role in the area of optical disc inspection since 1986, and has developed a series of systems for use with audio CD's. With the advent of higher speed requirements in production technology, and the emergence of interest in video, WORM, and MO discs, AID has been developing systems that afford higher speeds, improved resolution, and better defect classification. In addition, AID has designed systems to meet new optical disc requirements, including bar code readers, catalog ID systems, and disc counters. The systems and their capabilities are described, as are the requirements that future systems will have to meet.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Individuals in Context and Contexts in Individuals (1999)

This presentation will explore some ideas about the impact of both external and internal contexts on what we, whether as clients or therapists, do. It will offer a way of thinking about the internal and external as sides of the same coin, and a justification for working directly with one or the other whilst holding both in mind. In reflecting on how the internal and external affect therapists, attention will be given to both the hidden influence of personal experience in our ideas and the influence of radical doubt.
Neutralizing Monoclonal Antibodies against Hepatitis C Virus E2 Protein Bind Discontinuous Epitopes and Inhibit Infection at a Postattachment Step (2011)

The E2 glycoprotein of hepatitis C virus (HCV) mediates viral attachment and entry into target hepatocytes and elicits neutralizing antibodies in infected patients. To characterize the structural and functional basis of HCV neutralization, we generated a novel panel of 78 monoclonal antibodies (MAbs) against E2 proteins from genotype 1a and 2a HCV strains. Using high-throughput focus-forming reduction or luciferase-based neutralization assays with chimeric infectious HCV containing structural proteins from both genotypes, we defined eight MAbs that significantly inhibited infection of the homologous HCV strain in cell culture. Two of these bound E2 proteins from strains representative of HCV genotypes 1 to 6, and one of these MAbs, H77.39, neutralized infection of strains from five of these genotypes. The three most potent neutralizing MAbs in our panel, H77.16, H77.39, and J6.36, inhibited infection at an early postattachment step. Receptor binding studies demonstrated that H77.39 inhibited binding of soluble E2 protein to both CD81 and SR-B1, J6.36 blocked attachment to SR-B1 and modestly reduced binding to CD81, and H77.16 blocked attachment to SR-B1 only. Using yeast surface display, we localized epitopes for the neutralizing MAbs on the E2 protein. Two of the strongly inhibitory MAbs, H77.16 and J6.36, showed markedly reduced binding when amino acids within hypervariable region 1 (HVR1) and at sites ∼100 to 200 residues away were changed, suggesting binding to a discontinuous epitope. Collectively, these studies help to define the structural and functional complexity of antibodies against HCV E2 protein with neutralizing potential.
IPv6 Stateless Address Autoconfiguration (1996)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements.
Cell 생산방식에 의한 다품종소량 생산 시스템의 최적화 (2018)

In order to produce products in response to the orders that require different functions for each customer, Company A seeks to identify and improve the problems of the line-lot production method, which is the production method adopted by the existing company A. Through this study, it was possible to improve production flexibility and productivity by changing to cell production method suitable for small quantity production of various kinds so as to flexibly respond to market and customer‘s demands. Through these improvements, we will be able to respond to diversified customer needs in real time as well as improve productivity and profit generation.
In addition, it acted positively to cultivate the work capacity of the production worker of company A, which served as an opportunity to increase the expectation of the fun of work and the compensation accordingly.
SMART: support management automated reasoning technology for compaq customer service (1992)

Sanchez-Sanchez, J, Raya-González, J, Ramirez-Campillo, R, Chaabene, H, Petisco, C, and Nakamura, FY. The increased effectiveness of resistance training on unstable vs. stable surfaces on selected measures of physical performance in young male soccer players. J Strength Cond Res 36(4): 888-894, 2022-To examine the effects of 10-week (2/wk) resistance training on stable vs. unstable surfaces on selected measures of physical performance in young male soccer players, national-level U19 players participated in this study. They were randomly allocated to an unstable resistance training group (uRT, n = 27) or a stable resistance training group (sRT, n = 28). Before and after the training, horizontal jumping with dominant (Hop D) and nondominant leg (Hop non-D), repeated sprint ability (RSA best time [RSAbest] and RSA mean time [RSAmean]), change-of-direction (COD) speed (Illinois COD test), and aerobic endurance (YoYo Intermittent Recovery Test Level 1 [YoYo IR1]) were assessed. To establish the effects of the interventions on the dependent variables, a 2 (group: uRT and sRT) × 2 (time: pre, post) analysis of variance with repeated measures on time was computed. A significant main effect of time was observed for Hop non-D, RSAbest, and RSAmean (p = 0.003-0.06, effect size [ES] = 0.06-0.15). Furthermore, significant group × time interactions were shown for RSAbest (p = 0.007, ES = 0.13) and RSAmean (p = 0.002, ES = 0.2). Post hoc analysis revealed significant pre- to post-training improvements for RSAbest (p = 0.002, ES = 0.35) and RSAmean (p = 0.0002, ES = 0.36) in the uRT. In the sRT, however, no significant pre-post performance changes were observed in RSAbest and RSAmean. In conclusion, 10 weeks of an in-season resistance training on unstable conditions in addition to regular soccer training was effective in improving repeated-sprint ability performance in youth male elite soccer players including maximal linear sprinting and the ability to perform repeated sprint.
Lung and heart-lung transplantation (2009)

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Genetic susceptibility of lung cancer associated with common variants in the 3′ untranslated regions of the adenosine triphosphate‐binding cassette B1 (<i>ABCB1</i>) and <i>ABCC1</i> candidate transporter genes for carcinogen export (2008)

The current study demonstrated that common polymorphisms in the 3' untranslated region of ABCB1 and ABCC1 may contribute to the etiology of lung cancer, providing further support for the hypothesis that genetic components in the metabolism and the disposition of NNK may modify the risk of lung cancer, especially in lung adenocarcinoma among women. Functional studies are warranted to elucidate whether aberrant expression and dysfunction of ABC transporters for carcinogen export may play a role in the development of lung cancer.