gebhart/patrepeval huggingface dataset:
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure (1992)

Diuretic activities of xanthine or nonxanthine adenosine antagonists and their ameliorative effects against glycerol-induced acute renal failure in rats were investigated in order to clarify the physiological and pathological function of adenosine receptors in the kidney. Diuretic and natriuretic activities of a variety of adenosine antagonists clarified systematically for the first time that the blockade of A1 receptors is more important than that of A2 receptors in sodium and water excretion and support the hypothesis that endogenous intrarenal levels of adenosine directly enhance tubular sodium readsorption. Studies of structure-activity relationships of 8-substituted xanthines in the acute renal failure demonstrated that the activation of adenosine A1 receptor was an important factor in developing such a renal failure. A series of 8-(3-noradamantyl)xanthines exhibited the extremely potent diuretic and natriuretic activities (24; 2.5 micrograms/kg, po, the ratio of urinary excretion value in treated rats to urinary excretion value in control rats = 1.69, the ratio of Na+/K+ in treated rats to Na+/K+ in control rats = 1.76) and potent ameliorative effects against glycerol-induced acute renal failure (24; 10 micrograms/kg, ip, 55% inhibition). From our detailed studies of structure-activity relationships, we can speculate that some tissue differences of the adenosine A1 receptor might exist between kidney and brain and sites of action for adenosine antagonists could be different between two renal pharmacological assays. 1,3-Dipropyl-8-(3-noradamantyl)xanthine, KW-3902 (24), was chosen for further studies and is under development as a drug for treating the acute renal failure.
Challenging times ahead (2008)

The global economic challenges will not only affect the banks but also healthcare staff and their patients. Indeed, no-one will be unaffected. At this moment community nurses are not being properly reimbursed for the cost of using their cars to deliver care in the home as the price of petrol rises ever higher and older people are counting the cost of ever rising energy and food costs. Additionally there will be less extra money available to fund public services as the government attempts to balance its expenditure against tax receipts without further increasing government debt.
Lightweight, high-resolution monitoring for troubleshooting production systems (2008)

Production systems are commonly plagued by intermittent problems that are difficult to diagnose. This paper describes a new diagnostic tool, called Chopstix, that continuously collects profiles of low-level OS events (e.g., scheduling, L2 cache misses, CPU utilization, I/O operations, page allocation, locking) at the granularity of executables, procedures and instructions. Chopstix then reconstructs these events offline for analysis. We have used Chopstix to diagnose several elusive problems in a largescale production system, thereby reducing these intermittent problems to reproducible bugs that can be debugged using standard techniques. The key to Chopstix is an approximate data collection strategy that incurs very low overhead. An evaluation shows Chopstix requires under 1% of the CPU, under 256KB of RAM, and under 16MB of disk space per day to collect a rich set of system-wide data.
Effect of magnetic treatment of irrigation water and seed on some vegetative characteristics and production of black seed "Nigella sativa (2012)

Seeds of Nigella sativa were sown in containers containing 15kg Loamy soil. The seeds were divided before sewing into two groups. The first group was soaked with ordinary tap water end the second group was treated with magnetized water for 24hrs. The irrigation process was completed until 75% of capacity field with two types of water (tap water of magnetized water with three replications).The magnetized water was obtained from special electric device designed for this purposeRecorded measurements (plants height, the number of branches/ plant, dry weight ofplant, number of flowers, 1000 seed weight) during the harvest period.Results indicated that the seed group which was treated with magnetized water was more significant than the one which was treated with the normal water in all the studied characteristics.
Differential Roles of Two Tandem E2F Sites in Repression of the Human p107 Promoter by Retinoblastoma and p107 Proteins (1995)

Although many lines of evidence indicate that the cellular protein p107 is closely related to the retinoblastoma protein, the exact function of the p107 gene and its regulation are presently not known. To investigate the molecular mechanism controlling expression of the human p107 gene, a 5' flanking sequence of this gene was isolated and shown to promote high-level expression of a luciferase reporter gene in cycling human 293 and Saos-2 cells. Sequencing and transcription mapping analyses showed that the human p107 promoter is TATA-less and contains a tandem, direct repeat of E2F-binding sites, with the 3' copy overlapping the major transcription initiation site. Deletion analysis of the p107 promoter showed that a promoter DNA fragment containing only the two E2F sites together with the leader sequence could direct relatively efficient expression in 293 cells. Site-directed mutagenesis of these E2F sites revealed that although both sites were important for p107 promoter activity, mutation on the proximal, initiation site copy of the E2F site showed a stronger effect. The human p107 promoter could be repressed by the retinoblastoma protein and its own gene product. Interestingly, the repression was found to be mediated through the 5' copy of the E2F site. These studies demonstrate for the first time differential roles of two tandem E2F sites in promoter regulation.
Introduction to the Physics of Organic Semiconductors (2005)

This chapter contains sections titled: History Materials Basic Properties of Organic Semiconductors Optical Properties Charge Carrier Transport Device Structures and Properties Outline of this Book
Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin. (1990)

Streptonigrin, a nonintercalative antitumor antibiotic, induced mammalian topoisomerase II dependent DNA cleavage in vitro. The cleavage activity of streptonigrin was comparable to that of demethylepipodophyllotoxin ethylidene-beta-D-glucoside at a low concentration (less than or equal to 10 microM) but one-third lower at a higher concentration (greater than 250 microM). Exposure of a reaction mixture containing streptonigrin, DNA, and topoisomerase II to an elevated temperature (65 degrees C) resulted in substantial reduction in DNA cleavage, suggesting that the mechanism of the topoisomerase II dependent DNA cleavage induced by streptonigrin was through the formation of a cleavage complex previously reported for topoisomerase II poisons such as 4'-(9-acridinylamino) methanesulfon-m-anisidide and epipodophyllotoxins.
Die-to-Wafer Bonding of Thin Dies using a 2-Step Approach; High Accuracy Placement, then Gang Bonding (2010)

25 um thick dies, mounted on thick carrier die, were placed on a 300mm landing wafer using the High Accuracy Die Bonder SET-FC300. The bonding process was either Cu/Cu or Cu/Sn with respective pitch of 10μm and 40μm. A special test structure was designed on the landing die to electrically determine the alignment accuracy after bonding - both with respect to the X-Y alignment and the rotation. Stacks were then assembled by collective hybrid bonding process. The top die is aligned and placed on the landing wafer coverer by a patterned polymer acting as a temporary alignment holder, and then the populated wafer is moved to a wafer bonder where all the dies are collectively bonded. Electrical measurements on the alignment structures indicate that maximum misalignment of the TSV to the landing pad is in the range of 1.5–1.75 um and the maximum rotation of the die is 0.03 degrees.
Fault Diagnosis of Aeroengine Sensor Based on Support Vector Machine (2011)

In view of the aero engine sensor fault phenomena, combined with sparse support vector machines and robustness, aero engine sensor fault diagnosis is designed by using SVM. SVM is trained out of line, and used on line. Compared the output results with the actual system output, it can produce high precision fault residuals by the simulation system's dynamic characteristics which was having been trained in accordance with SVM as the core, through the residuals to determine sensor failure. The simulation results show that the method in the aviation engine sensor fault diagnosis can be better to simulate the dynamic characteristics of the tested system, and can timely and accurately locate faults.
Surgical management of malignant melanoma (1995)

Wide and mutilating surgical excision is contraindicated for primary malignant melanoma. Tumours less than 1 mm thick require only 1 cm excision margins while those 1-4 mm thick need only 2 cm margins. Primary closure without skin grafting should always be attempted. Axillary and inguinal block dissection remain standard treatment for established lymphatic metastases but elective block dissection is still controversial and should only be performed in the context of a clinical trial. Selective lymphadenectomy based on intraoperative lymphatic mapping is being evaluated. Isolated limb perfusion plays an important role in palliation, and perfusion with a combination of cytotoxic agents and cytokines is an exciting therapeutic advance. Laser vapourization under local or general anaesthesia is an alternative way of treating multiple small cutaneous and subcutaneous lesions and is much better tolerated.
Numerical calculations of the pH of maximal protein stability (2003)

A large number of proteins, found experimentally to have different optimum pH of maximal stability, were studied to reveal the basic principles of their preference for a particular pH. The pH-dependent free energy of folding was modeled numerically as a function of pH as well as the net charge of the protein. The optimum pH was determined in the numerical calculations as the pH of the minimum free energy of folding. The experimental data for the pH of maximal stability (experimental optimum pH) was reproducible (rmsd = 0.73). It was shown that the optimum pH results from two factors - amino acid composition and the organization of the titratable groups with the 3D structure. It was demonstrated that the optimum pH and isoelectric point could be quite different. In many cases, the optimum pH was found at a pH corresponding to a large net charge of the protein. At the same time, there was a tendency for proteins having acidic optimum pHs to have a base/acid ratio smaller than one and vice versa. The correlation between the optimum pH and base/acid ratio is significant if only buried groups are taken into account. It was shown that a protein that provides a favorable electrostatic environment for acids and disfavors the bases tends to have high optimum pH and vice versa.
Edge Analytics in the Internet of Things (2015)

High-data-rate sensors, such as video cameras, are becoming ubiquitous in the Internet of Things. This article describes GigaSight, an Internet-scale repository of crowd-sourced video content, with strong enforcement of privacy preferences and access controls. The GigaSight architecture is a federated system of VM-based cloudlets that perform video analytics at the edge of the Internet, thus reducing the demand for ingress bandwidth into the cloud. Denaturing, which is an owner-specific reduction in fidelity of video content to preserve privacy, is one form of analytics on cloudlets. Content-based indexing for search is another form of cloudlet-based analytics. This article is part of a special issue on smart spaces.
Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy (2011)

Topical glucocorticoids are highly anti-inflammatory effective but limited by their side effect potential, with skin atrophy being the most prominent one. Thus, determining the atrophogenic potential of novel compounds targeting the glucocorticoid receptor is important. Significant progress in the understanding of glucocorticoid receptor mediated molecular action has been made providing the basis for novel glucocorticoid receptor ligands with a potentially superior effect/side effect profile. Such compounds, however, need to be tested. The present gold standard for the reliable prediction of glucocorticoid induced skin atrophy are still in vivo models, however, in vitro models may replace them to some extent in the future. Indeed, advances in technologies to determine the atrophogenic potential of compounds in vitro has been made recently and promising novel test models like the human full thickness skin models are emerging. Their full predictive value, however, needs to be further evaluated. Currently, a screening approach starting with a combination of several in vitro test systems followed by subsequent testing of the most promising compounds in rodent models is recommended prior entering clinical studies with selected development compounds.
Building script-based tacit knowledge in call centre trainees (2010)

An exploratory case study on a technical support call centre in China is presented, which investigates a new paradigm that script-based tacit knowledge for action is built in the brains of learners, rather than transferred. Twelve techniques used by the case study organization to build tacit knowledge scripts in the minds of the trainees are discussed. It was found that one type of script-based tacit knowledge execution can be represented by a set of steps in action-taking that include awareness, attention, diagnosis, action alternative analysis, action taking, and outcome evaluation. The case findings show that the notion of building, rather than transferring tacit knowledge is helpful in understanding the organizational processes used to bring new employees up to working skill levels, and suggest that similar processes and training methods for building tacit knowledge scripts can be used by other organizations to transform a new recruit to an experienced and valued employee.
Fast image synthesis of virtual objects in a real scene with natural shadings (2005)

We propose a new method for superimposing synthetic objects with natural shadings and cast shadows onto a real scene whose illumination condition is dynamically changing in this paper. In general, high computational cost for rendering virtual objects with convincing shading and shadows, such as interreflections or shadows under area light sources, prohibits real-time synthesis of such composite images with superimposed virtual objects. To overcome this limitation, we take advantage of the linearity of the relationship between brightness changes observed on an object surface and change of illumination radiance in a scene and introduce an efficient rendering technique based on a linear combination of pre-rendered reference images of the scene. We have successfully tested the proposed method in a natural illumination condition of an indoor environment to demonstrate how fast the method could superimpose a virtual object onto the scene with highly realistic shadings and shadows. © 2005 Wiley Periodicals, Inc. Syst Comp Jpn, 36(14): 102–111, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/scj.10155
Acute Decompensated Heart Failure (2012)

Acute decompensated heart failure (ADHF) is a major public health problem throughout the world and its importance is continuing to grow. This article reviews the epidemiology of ADHF and the profile of patients suffering from this condition. It describes factors used in assessing prognosis and presents treatment options. Although no currently available treatments have been shown to favorably affect long-term outcomes, there are a variety of strategies and approaches to management that are expected to reduce morbidity and mortality following discharge after ADHF hospitalization. In particular, the clinician is alerted to the need to identify factors that trigger decompensation as well as to optimize treatments for chronic heart failure. The importance of the transition from hospital to the outpatient setting is described. Particular attention should be focused on providing health education to the patient and their family at an appropriate level of medical literacy as well as ensuring early follow-up evaluation after hospital discharge.
Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis (2014)

The original definition of atypical antipsychotic drugs (APD) was drugs that are effective against positive symptoms in schizophrenia with no or little extrapyramidal symptoms (EPS). However, atypical APD have been reported to be more effective for cognitive dysfunction and negative symptoms in schizophrenia than typical APD, which expands the definition of 'atypicality'. This article provides a critical review of the pharmacology of atypical APD, especially from the viewpoint of receptor binding profiles and neurotransmitter regulations as well as neuroprotection and neurogenesis. A variety of serotonin (5-HT) receptors, such as 5-HT2A / 2C , 5-HT1A , 5-HT6 and 5-HT7 receptors, may contribute to the mechanisms of action of 'atypicality'. The dopaminergic modulations, including a low affinity for dopamine D2 receptors and a partial D2 receptor agonistic action, and glutamatergic regulations may also be involved in the pharmacological backgrounds of 'atypicality'. Atypical APD, but not typical APD, may facilitate cortical neuroprotection and hippocampal neurogenesis, which might be a part of the action mechanisms of atypical APD. The facilitation of cortical neuroprotection and hippocampal neurogenesis induced by atypical APD might be mediated by an increase in the Ser9 phosphorylation of glycogen synthase kinase-3β (GSK-3β). The stimulation of 5-HT1A receptors and/or the blockade of 5-HT2 receptors, which is characteristic of atypical APD, might increase Ser9 phosphorylation of GSK-3β. Moreover, atypical APD increase brain-derived neurotrophic factor (BDNF) levels. BDNF increases Ser9 phosphorylation of GSK-3β and has neuroprotective and neurogenic effects, as in the case of atypical APD. These findings suggest that GSK-3β might play a role in the action mechanisms of atypical APD, in both the 5-HT-dependent and BDNF-dependent mechanisms.
Broadband optical equalizer using fault tolerant digital micromirrors (2003)

For the first time, the design and demonstration of a near continuous spectral processing mode broadband equalizer is described using the earlier proposed macro-pixel spatial approach for multiwavelength fiber-optic attenuation in combination with a high spectral resolution broadband transmissive volume Bragg grating. The demonstrated design features low loss and low polarization dependent loss with broadband operation. Such an analog mode spectral processor can impact optical applications ranging from test and instrumentation to dynamic alloptical networks.
Lambda-Display: A Powerful Tool for Antigen Discovery (2011)

Since its introduction in 1985, phage display technology has been successfully used in projects aimed at deciphering biological processes and isolating molecules of practical value in several applications. Bacteriophage lambda, representing a classical molecular cloning and expression system has also been exploited for generating large combinatorial libraries of small peptides and protein domains exposed on its capsid. More recently, lambda display has been consistently and successfully employed for domain mapping, antigen discovery and protein interaction studies or, more generally, in functional genomics. We show here the results obtained by the use of large libraries of cDNA and genomic DNA for the molecular dissection of the human B-cell response against complex pathogens, including protozoan parasites, bacteria and viruses. Moreover, by reviewing the experimental work performed in recent investigations we illustrate the potential of lambda display in the diagnostics field and for identifying antigens useful as targets for vaccine development.
The AUV positioning using ranges from one transponder LBL (2002)

An autonomous underwater vehicle (AUV) positioning method using the range data from one transponder of a long base line acoustic positioning system and the yaw and relative velocity information from an on board autonomous navigation system is described in the paper. The localization algorithm is based on the least squares root method. The algorithm allows one to calculate the AUV position and current velocity estimations. The simulation results of the method are supplemented.
AldehydeAmine Chemistry Enables Tissue Adhesive Materials to Respond to Physiologic Variation and Pathologic States (2013)

Abstract Biomaterials science represents the next frontier in medical therapeutics. Innovations in materials design and formulation have helped create previously unimaginable interventions and composite devices with materials whose structure and function evolve with time. Yet, materials development has outstripped our ability to explain why, when, and how these materials work. Current characterization means are limited, especially for dynamic erodible materials that are specifically designed to fade away. This complexity and dynamism of emerging materials and the impact they have on tissue make it challenging to understand and predict material interactions with local tissues. Because tissuebiomaterials interactions are determined not only by the innate properties of the materials, but also by the local microenvironment at the implantation site, we must now examine the impact of target tissue site, state, and incidence of a disease on material performance, efficacy, and biocompatibility. This issue becomes increasingly important when considering surface interacting materials, whose intimate interactions with tissues are dictated by local mechanical forces, tissue target site, and the modulation of tissue surface properties manifested by specific disease types and states. The mechanisms involved and the extent to which these parameters affect the in vivo performance of materials are mostly unknown. These open questions motivated us to explore the determinant factors that affect the efficacy of materials, using adhesive materials whose surface interactions with tissues make them an ideal material class for the assessment of tissuematerial interactions. As an example of this paradigm, we determined how tissue amines served as a natural binding site for material aldehydes, enabling tissue‐specific binding that varied with natural changes in amine density from tissue to tissue and the physiologic environment, as well as with disease. The introduction of amines within the material also provides greater control over binding and material cohesion. This general mode will provide new tissue adhesives that can sense local tissue states and provide mechanical interactions titrated to context and need to enhance the desired effect and minimize local toxicity.
Factors that degrade the match distribution in iris biometrics (2009)

We consider three “accepted truths” about iris biometrics, involving pupil dilation, contact lenses and template aging. We also consider a relatively ignored issue that may arise in system interoperability. Experimental results from our laboratory demonstrate that the three accepted truths are not entirely true, and also that interoperability can involve subtle performance degradation. All four of these problems affect primarily the stability of the match, or authentic, distribution of template comparison scores rather than the non-match, or imposter, distribution of scores. In this sense, these results confirm the security of iris biometrics in an identity verification scenario. We consider how these problems affect the usability and security of iris biometrics in large-scale applications, and suggest possible remedies.