gebhart/patrepeval huggingface dataset:
Functional involvement of P‐selectin and MAdCAM‐1 in the recruitment of α4β7‐integrin‐expressing monocyte‐like cells to the pregnant mouse uterus (2004)

Leukocyte recruitment to the pregnant mouse uterus has been suggested to be associated with highly regulated expression of distinct patterns of vascular adhesion receptors. One of the most striking observations is the combined expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and P-selectin by maternal vessels of the vascular zone during the critical period of initial placenta development. The predominant cell population within these vessels is of the monocyte/macrophage lineage and expresses the mucosal integrin alpha4beta7, which represents the ligand for MAdCAM-1; neutrophils and lymphocytes are rare. To directly assess the importance of identified adhesion receptors, we undertook long-term in vivo inhibition studies using monoclonal antibodies to inhibit the contribution of MAdCAM-1 in leukocyte trafficking to the decidua or to deplete alpha4beta7(+) leukocytes. In addition, implantation sites of mouse strains genetically deficient in specific adhesion receptors were investigated. Our results underline the importance of predicted adhesion pathways in the recruitment of monocyte-like cells, especially those expressing alpha4beta7. Interestingly, maternal/fetal units with inhibited recruitment of alpha4beta7(+) leukocytes or the absence of these cells are characterized by reduced size and frequency of uterine NK cells.
Reaction of anti-HLA-B monoclonal antibodies with envelope proteins of <i>Shigella</i> species. Evidence for molecular mimicry in the spondyloarthropathies. (1988)

Immunologic cross-reactivity between enteric bacteria and the HLA-B27 protein may play a role in the etiology of Reiter's syndrome and reactive arthritis. The reactivity of two anti-B27 mAb (B27M1 and B27M2) with envelope proteins of Shigella flexneri isolated from Reiter's syndrome patients was studied by Western blot analysis. Proteins with an apparent Mr of approximately 36 and 23 kDa reacted with both mAb in ascites. mAb against related HLA class I Ag B7 and B40 did not react with the 23 kDa protein. Relatively high concentrations of antibody were required for reactivity, suggesting a low affinity interaction. Additional evidence for cross-reactive epitopes was obtained by ELISA against whole envelope and by using unsolubilized envelope to inhibit binding of M1 and M2 to B27-positive cell lines, as measured by quantitative flow microfluorimetry. The presence of cross-reactive proteins was not related to the presence of the intact virulence-associated plasmid or the invasive phenotype. Two Shigella sonnei isolates not implicated as causative agents of Reiter's syndrome or reactive arthritis showed a similar pattern of cross-reactivity. These results indicate that cross-reactive epitopes may be present on "arthritogenic" bacteria, but their presence is not a unique feature of such strains and is not the sole factor in induction of arthritis in B27-positive individuals.
On the performance of hierarchical distributed correspondence graphs for efficient symbol grounding of robot instructions (2015)

Natural language interfaces are powerful tools that enables humans and robots to convey information without the need for extensive training or complex graphical interfaces. Statistical techniques that employ probabilistic graphical models have proven effective at interpreting symbols that represent commands and observations for robot direction-following and object manipulation. A limitation of these approaches is their inefficiency in dealing with larger and more complex symbolic representations. Herein, we present a model for language understanding that uses parse trees and environment models both to learn the structure of probabilistic graphical models and to perform inference over this learned structure for symbol grounding. This model, called the Hierarchical Distributed Correspondence Graph (HDCG), exploits information about symbols that are expressed in the corpus to construct minimalist graphical models that are more efficient to search. In a series of comparative experiments, we demonstrate a significant improvement in efficiency without loss in accuracy over contemporary approaches for human-robot interaction.
Enzymatic activity of soluble phospholipase A<sub>2</sub> does not affect the specific IgE, IgG4 and cytokine responses in bee sting allergy (1998)

The enzymatic activity of PLA does not influence the specific activation and cytokine production by T cells from bee venom-sensitized or hyperimmune individuals, or the IgE/IgG4 antibodies synthesis by B cells in vitro.
Anterior fiber-reinforced composite resin bridge: a case report. (2005)

A variety of therapeutic modalities, from implants to conventional Maryland bridges, can be used for the replacement of a traumatically missing anterior tooth. The reinforcement of composite resins by fibers improves their fracture toughness and resistance. Fiber-reinforced composite (FRC) bridges can be a good alternative to conventional prosthetic techniques. The purpose of this article was to present a clinical case of a single tooth replacement by means of a polyethylene FRC bridge. A semi-direct technique was used to fabricate a Maryland-like composite bridge for the replacement of a missing central permanent incisor. The bridge fabrication was done in the dental office using a fast-setting polyvinylsiloxane die material and a state-of-art restorative composite resin. This technique offers a conservative, esthetic, and noninvasive treatment. Moreover, this technique is economically more acceptable, nonirritating, and noniatrogenic. Polyethylene FRC bridges can be considered as a permanent treatment or, in the case of implant placement after the end of the growth period, as a long-lasting reversible provisional treatment.
Stress and obesity: the role of the hypothalamic–pituitary–adrenal axis in metabolic disease (2009)

The present review provides evidence for the relationship between chronic stress, alterations in HPA activity, and obesity. Understanding these associations and its interactions with other factors will be important in developing effective treatments for obesity and related metabolic diseases.
CORN (2011)

Machine learning techniques have been adopted to select portfolios from financial markets in some emerging intelligent business applications. In this article, we propose a novel learning-to-trade algorithm termed COR relation-driven N onparametric learning strategy (CORN) for actively trading stocks. CORN effectively exploits statistical relations between stock market windows via a nonparametric learning approach. We evaluate the empirical performance of our algorithm extensively on several large historical and latest real stock markets, and show that it can easily beat both the market index and the best stock in the market substantially (without or with small transaction costs), and also surpass a variety of state-of-the-art techniques significantly.
Fluorescence and Near-Field Scanning Optical Microscopy for Investigating Initiation of Localized Corrosion of Al 2024 (2000)

The localized corrosion behavior of Al 2024 was investigated by using a fluorescent dye in combination with conventional fluorescence microscopy and near‐field scanning optical microscopy. The fluorescent rings that mark the first steps of corrosion attack were associated with topographic features. The topographic rings were also observed in the absence of the dye, demonstrating that the observed rings are not artifacts. Anodic polarization in the absence of oxygen yielded fluorescent and topographic features similar to those observed under open‐circuit conditions, indicating that the dye marks anodic sites. © 2000 The Electrochemical Society. All rights reserved.
Online Analytical Mining of Path Traversal Patterns for Web Measurement (2002)

The WWW and its associated distributed information services provide rich world-wide online information services, where objects are linked together to facilitate interactive access. Users seeking information of Internet traverse from one object via links to another. It is important to analyze user access patterns which will help improve Web page design by providing an efficient access between highly correlated objects, and also assist in better marketing decisions by placing advertisements in frequently visited document. We need to study the user surfing behavior by examining the Web access log, browsing frequency of Web pages and computing the average duration time of visit. This paper offers an architecture to store the derived web user access paths in a data warehouse, and facilitates its view maintainability by use of a metadata. The system will update the user access paths pattern with the data warehouse by the data operation functions in the metadata. Whenever a new user access path occurs, the view maintainability is triggered by a constraint class in the metadata. The data warehouse can be analyzed on the frequent pattern tree of user access paths on the Website within a period and duration. The result is an online analytical mining path traversal pattern. Our experimental and performance studies have demonstrated the effectiveness and efficiency of our system with the following contributions: an architecture of online analytical mining (OLAM) using frame model metadata, a methodology (stepwise procedure) of implementing OLAM and the resultant cluster of web pages frequently visited by users for marketing use.
New solderless connection technology using light-setting insulation resin (2002)

A new solderless connection technology using light-setting insulation resin has been developed. This makes possible fine-pitch and short length connection between the FPC (Flexible Printed Circuit) and the electrodes of an electronic device. An FPC is attached by the adhesive force of the light-setting insulation resin. This technology has been applied to a thin-film magnetic head, and realized ultra fine connection, i.e. a connection pitch of 75 /spl mu/m (present ratio 1/2) and a connection length of 250 /spl mu/m (present ratio 1/10).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
March Tests Improvements for Address Decoder Open and Resistive Open Fault Detection (2004)

International audience
Low Cost Fuel Cell Converter System for Residential Power Generation (2004)

The high installation cost is the major obstacle of the commercialization of the solid oxide fuel cell for distributed power generation. This paper presents a new low cost 10-kW converter system to overcome this obstacle. The proposed system consists of an isolated dc-dc converter to boost the fuel cell voltage to 400 V dc and a pulse-width modulated inverter with filter to convert the dc voltage to two split-phase 120-V ac. The dc-dc converter uses phase shifting to control power flow through a transformer with a metal oxide semiconductor field effect transistor full bridge on the low voltage side and a voltage doubler on the high voltage side. One IPM is used to realize the voltage doubler and the dc-ac inverter. Compared to the existing fuel cell converter systems, the proposed circuit has low cost, less component count, smaller size, and reduced dc-dc converter peak current. Simulation and experimental results are demonstrated.
Towards Best Region Search for Data Exploration (2016)

The increasing popularity and growth of mobile devices and location-based services enable us to utilize large-scale geo-tagged data to support novel location-based applications. This paper introduces a novel problem called the best region search (BRS) problem and provides efficient solutions to it. Given a set O of spatial objects, a submodular monotone aggregate score function, and the size a x b of a query rectangle, the BRS problem aims to find a x b rectangular region such that the aggregate score of the spatial objects inside the region is maximized. This problem is fundamental to support several real-world applications such as most influential region search (eg. the best location for a signage to attract most audience) and most diversified region search (eg. region with most diverse facilities). We propose an efficient algorithm called SliceBRS to find the exact answer to the BRS problem. Furthermore, we propose an approximate solution called CoverBRS and prove that the answer found by it is bounded by a constant. Our experimental study with real-world datasets and applications demonstrates the effectiveness and superiority of our proposed algorithms.
On-demand preparation of quantum dot-encoded microparticles using a droplet microfluidic system (2011)

Optical barcoding technology based on quantum dot (QD)-encoded microparticles has attracted increasing attention in high-throughput multiplexed biological assays, which is realized by embedding different-sized QDs into polymeric matrixes at precisely controlled ratios. Considering the advantage of droplet-based microfluidics, producing monodisperse particles with precise control over the size, shape and composition, we present a proof-of-concept approach for on-demand preparation of QD-encoded microparticles based on this versatile new strategy. Combining a flow-focusing microchannel with a double T-junction in a microfluidic chip, biocompatible QD-doped microparticles were constructed by shearing sodium alginate solution into microdroplets and on-chip gelating these droplets into a hydrogel matrix to encapsulate CdSe/ZnS QDs. Size-controllable QD-doped hydrogel microparticles were produced under the optimum flow conditions, and their fluorescent properties were investigated. A novel multiplex optical encoding strategy was realized by loading different sized QDs into a single droplet (and thus a hydrogel microparticle) with different concentrations, which was triggered by tuning the flow rates of the sodium alginate solutions entrapped with different-colored QDs. A series of QD-encoded microparticles were controllably, and continuously, produced in a single step with the present approach. Their application in a model immunoassay demonstrated the potential practicability of QD-encoded hydrogel microparticles in multiplexed biomolecular detection. This simple and robust strategy should be further improved and practically used in making barcode microparticles with various polymer matrixes.
A Model for the Prediction of Thermal, Prompt, and Fuel NOx Emissions From Combustion Turbines (1986)

A model has been developed for the prediction of NOx emissions from combustion turbines. Thermal, prompt, and fuel NO are all treated and are all assumed to be formed at a stoichiometric equivalence ratio. Prompt and fuel NO are assumed to be fast with respect to thermal NO and establish a finite concentration of NO at the beginning of the thermal NO formation process. Thermal NO is calculated via the extended Zeldovich mechanism; a thermal NO formation time is determined from the ratio of flame length to convective velocity within the combustor. Prompt NO is assumed to be formed from the hydrocarbon chemistry and is related to the equilibrium concentration of NO rather than to O-atom overshoot. Fuel NO is calculated assuming an indispensible intermediate in the formation mechanism and a constant Fenimore α parameter for combustion turbine flames. The model employs equilibrium hydrocarbon chemistry; the flame temperature and concentrations of key species are determined in an equilibrium subroutine. The effects of water or steam injection and ambient humidity are included through their impact on the flame temperature and species concentrations. The model has been applied to can-type combustors and its accuracy has been verified by data on high and low nitrogen fuels with and without water injection, and on combustors of different geometry. The treatment of all three mechanisms of NO formation is unique to this model and permits prediction of emissions for the range of conventional and alternative fuels encountered in industrial combustion turbines.
Cruciform-extruding regulatory element controls cell-specific activity of the tyrosine hydroxylase gene promoter (1998)

Tyrosine hydroxylase (TH) is expressed specifically in catecholaminergic cells. We have identified a novel regulatory sequence in the upstream region of the bovine TH gene promoter formed by a dyad symmetry element (DSE1;-352/-307 bp). DSE1 supports TH promoter activity in TH-expressing bovine adrenal medulla chromaffin (BAMC) cells and inhibits promoter activity in non-expressing TE671 cells. DNase I footprinting of relaxed TH promoter DNA showed weak binding of nuclear BAMC cell proteins to a short sequence in the right DSE1 arm. In BAMC cells, deletion of the right arm markedly reduced the expression of luciferase from the TH promoter. However, deletion of the left DSE1 arm or its reversed orientation (RevL) also inactivated the TH promoter. In supercoiled TH promoter, DSE1 assumes a cruciform-like conformation i.e., it binds cruciform-specific 2D3 antibody, and S1 nuclease-cleavage and OsO4-modification assays have identified an imperfect cruciform extruded by the DSE1. DNase I footprinting of supercoiled plasmid showed that cruciformed DSE1 is targeted by nuclear proteins more efficiently than the linear duplex isomer and that the protected site encompasses the left arm and center of DSE1. Our results suggest that the disruption of intrastrand base-pairing preventing cruciform formation and protein binding to DSE1 is responsible for its inactivation in DSE1 mutants. DSE1 cruciform may act as a target site for activator (BAMC cells) and repressor (TE671) proteins. Its extrusion emerges as a novel mechanism that controls cell-specific promoter activity.
Lyapunov exponents from observed time series (1990)

We examine the question of accurately determining Lyapunov exponents for a time series. We find that it is advantageous to use local mappings with higher-order Taylor series, rather than linear maps as done earlier. We demonstrate this procedure for the Ikeda map and the Lorenz system. We present methods for identifying spurious exponents by analyzing data-set singularities and by determining the Lyapunov direction vectors. The behavior of spurious exponents in the presence of noise is also investigated, and found to be different from that of the true exponents.
Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease (2014)

While these data must still not be interpreted as evidence of neuroprotection, they nevertheless provide strong encouragement for the further study of this drug as a potential disease modifying agent in Parkinson's disease.
RANDOMIZATION BY CLUSTER (1981)

Sample size requirements are given for intervention trials in which the unit of randomization is the cluster. Cases dealt with include the comparison of two means and the comparison of two proportions. Required modifications to the standard statistical analyses are also discussed.
Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV) (2013)

JapicCTI-121902 for Phase II study, JapicCTI-101075 for Phase III study (http://www.clinicaltrials.jp/user/cte_main.jsp).
Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from <i>Caenorhabditis elegans</i> (2000)

Using a combination of database-mining and functional characterization, we have identified a component of the polyunsaturated fatty acid (PUFA) elongase. Co-expression of this elongating activity with fatty acid desaturases has allowed us to heterologously reconstitute the PUFA biosynthetic pathway. Both these enzymes (desaturases and elongase components) have undergone gene-duplication events which provide a paradigm for the diverged nature of PUFA biosynthetic activities.
Salinity stress adaptation competence in the extremophile <i>Thellungiella halophila</i> in comparison with its relative <i>Arabidopsis thaliana</i> (2005)

In stark contrast to Arabidopsis, a related species, Thellungiella halophila (Thellungiella salsuginea; salt cress), displays extreme tolerance to high salinity, low humidity and freezing. High nucleotide sequence identity permits the use of tools developed for Arabidopsis for Thellungiella transcript profiling, for which a microarray platform with >25,000 DNA elements (70-mer oligonucleotides) was used. Microarray transcript profiling and intensity analysis, quantitative RT-PCR, and metabolite profiles define genes and pathways that showed shared and divergent responses to salinity stress in the two species. Shared responses are exemplified by 40% of the regulated genes functioning in confining ribosomal functions, photosynthesis and cell growth, as well as activating osmolyte production, transport activities and abscisic acid-dependent pathways. An additional 60% of regulated genes distinguished Thellungiella from Arabidopsis. Analysis of the differences showed that Arabidopsis exhibited a global defense strategy that required bulk protein synthesis, while Thellungiella induced genes functioning in protein folding, post-translational modification and protein redistribution. At 150 mm NaCl, Thellungiella maintained unimpeded growth. Transcript intensity analyses and metabolite profiles supported the microarray results, pointing towards a stress-anticipatory preparedness in Thellungiella.
CEREBRAL CONCUSSION AND TRAUMATIC UNCONSCIOUSNESS (1974)

Journal Article CEREBRAL CONCUSSION AND TRAUMATIC UNCONSCIOUSNESS: CORRELATION OF EXPERIMENTAL AND CLINICAL OBSERVATIONS ON BLUNT HEAD INJURIES Get access AYUB K. OMMAYA, AYUB K. OMMAYA Search for other works by this author on: Oxford Academic PubMed Google Scholar T. A. GENNARELLI T. A. GENNARELLI Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 97, Issue 1, 1974, Pages 633–654, https://doi.org/10.1093/brain/97.1.633 Published: 01 January 1974 Article history Published: 01 January 1974 Received: 17 April 1974
Spinning-disk laser interferometers for immuno-assays and proteomics: the BioCD (2004)

Spinning-disk self-referencing laser interferometers are being developed as high-speed high-sensitivity platforms for immunoassay and proteomics applications. Their compact disc (CD) formats have the potential for ultra-high-throughput multianalyte assays as well as for binding kinetics and quantitative analysis. Self-referencing interferometers are immune to mechanical variations, enabling interferometric sensitivities and speeds that are several orders of magnitude larger than for their counterpart fluorometric techniques. This paper defines for the first time three classes of the BioCD that differ in their method of self-referencing and reviews their relative merits and sensitivities. Each uses a near-field probe with far-field detection. The three classes are: microdiffraction, adaptive optical, and photonic cavity.
The Ionization of Helium, Neon, and Argon by Electron Impact (1930)

Quantitative measurements have been made of the total number of positive charges produced per electron per cm path at a definite pressure, in helium, neon, and argon, as a function of the energy of the impacting electrons out to 4500 volts. In helium the maximum efficiency 1.256 occurs at 110 volts, in neon 3.008 at 170 volts, and in argon 13.01 at 88 volts.An empirical relation has been found which expresses the efficiency of ionization of helium within the experimental error for energies greater than 60 volts.The data obtained differ considerably from that found by previous investigations, but because of the more precise length of path from which the positive ions were measured and the more accurate knowledge of the energy of the electrons as well as the elimination of secondary electrons, it is believed that the results presented here are the most accurate thus far obtained.