gebhart/patrepeval huggingface dataset:
A Synchronous Fiber Optic Ring Local Area Network for Multigigabit/s Mixed-Traffic Communication (1985)

A synchronous-ring fiber optic local area network is reported that facilitates the simultaneous transmission of packet and real-time traffic at gigabit/s rates, minimizes the amount of high-speed logic, and simplifies the user interface to the network. The novelty of the technique is based on 1) suspending in transit around the ring's circumference an integral number of data frames and 2) achieving this condition by skewing the frame clock rate a small amount ( < 1 percent). Rather than use the whole data frame as one packet destined to a specific user (as in a slotted ring), we instead time multiplex many individual channels into the data frame. This technique only becomes feasible for local networks as data rates approach the Gbit/s range. This departure from other synchronous rings results in several advantages both in terms of system performance and hardware simplicity.
Chapter 5 - Blind Source Separation: Models, Concepts, Algorithms and Performance (2000)

International audience
Polyquinoxalines. II. (1965)

Abstract Five new high molecular weight polyquinoxalines have been prepared by the reactions of combinations of two tetramines, 3,3′‐diaminobenzidine (II) and 3,3′,4,4′‐tetraminodiphenyl ether (IV), with the three bisglyoxals, 1,4‐phenylenediglyoxal (I), 1,3‐phenylenediglyoxal (VI), and 4,4′‐oxydiphenylenediglyoxal (IX). Solution and melt polymerization techniques afford intermediate molecular weight polymers which can be converted to high molecular weight samples (η inh > 1.0) by heating at 375°C. under reduced pressure. All the polyquinoxalines have excellent thermal stability both in nitrogen and in air. Of these polymers, poly[2,2′‐(4,4′‐oxydiphenylene)‐6,6′‐oxydiquinoxaline] (XI) has the highest solubility in hexamethylphosphoramide (HMP), and films can be cast from intermediate molecular weight (η inh = 0.3–0.7) polymer solutions in HMP. Tough, insoluble films can be obtained by heating the cast films in nitrogen or under reduced pressure to 350–400°C.
Naturally occurring antibodies to liposomes. I. Rabbit antibodies to sphingomyelin-containing liposomes before and after immunization with unrelated antigens. (1979)

Liposomes were prepared from a mixture of sphingomyelin, cholesterol, and dicetylphosphate or L-alpha-dimyristoyl phosphatidylcholine, cholesterol, and dicetylphosphate, in the presence of glucose. The amount of trapped glucose released from these liposomes was monitored after incubation with a variety of normal and immune sera in the presence of guinea pig complement. All normal rabbit sera tested were found to release, in the presence of complement, detectable amounts of trapped glucose from sphingomyelin-containing liposomes. After immunization with a variety of unrelated antigens, the anti-sphingomyelin liposome activity increased signficantly and in direct proportion to the number of injections, despite the fact that the liposomes used in the assay did not contain the relevant antigen used for immunization. Liposomes prepared from dimyristoyl phosphatidylcholine showed only marginal release of their trapped marker when assayed with the same rabbit sera and complement. These liposomes, however, were fully reactive when the appropriate antigen was inserted in their bilayer structure. The antiliposome activity was associated mainly with the IgM antibody class. These results raise the interesting possibility that antigenic stimulation may trigger the activation of lymphocyte clones directed against autologous cell-membrane components that cross-react with artificial model membranes containing sphingomyelin.
Topical Review: Encephalopathy Associated With Hashimoto Thyroiditis: Pediatric Perspective (2006)

In recent years, neuropsychiatric symptoms associated with Hashimoto thyroiditis have been increasingly recognized in both adult and pediatric patients. This neurologic complication has been termed "Hashimoto encephalopathy," and it can begin abruptly, in the form of seizures or agitation, with or without other neurologic complaints, or it can develop gradually, in a relapsing-remiting manner, including, among others, cognitive deterioration and psychiatric illness. The occurrence of Hashimoto encephalopathy is unrelated to the patient's thyroid function status. Although the pathogenesis of this encephalopathy is not fully understood, evidence for both autoimmune and vasculitic mechanisms exists. Owing to a low index of suspicion, this encephalopathy is very likely underdiagnosed in children. The diagnosis of Hashimoto encephalopathy is based on detecting antithyroid antibodies in these patients, although there is no correlation between antibody levels and the severity of the illness. Cerebrospinal fluid analysis, electroencephalography, and neuroimaging studies do not show consistent findings to support the diagnosis. Physicians' awareness of this complication is of great importance because most patients respond dramatically to corticosteroid therapy. Moreover, early recognition might also avoid an expensive diagnostic work-up in patients with unexplained encephalopathy (J Child Neurol 2006;21:1-5).
Wire Bonding Challenges in Optoelectronics Packaging (2004)

Wire bonding has been used in integrated circuit (IC) packaging for many years. However, there are many challenges in wire bonding for optoelectronics packaging. These challenges include bonding on sensitive devices, bonding over cavity, bonding over cantilevel leads and bonding temperature limitations. The optoelectronics package design brings another challenge, which requires wire bonding to have deep access capability. In this paper, the wire bonding technologies are reviewed and ball bonding and wedge bonding are compared. The variables that affect the wire bonding process are then discussed. Finally, the challenges of wire bonding in optoelectronics packaging are presented in detail.
Palladium‐Catalyzed Sonogashira Coupling of Aryl Mesylates and Tosylates (2010)

Up to speed: The first general and mild protocol for the Sonogashira coupling of aryl mesylates is presented (see scheme). The coupling intermediate also provides facile access to 2-substituted isoquinolines.
Developing Biologically-Based Assessment Tools for Physical Therapy Management of Neck Pain (2009)

Diagnosis, level 5.
Lessons from <i>LyricTime</i> (1992)

No abstract available.
The influence of prosthetic stem stiffness and of a calcar collar on stresses in the proximal end of the femur with a cemented femoral component. (1984)

Loosening of the femoral stem and calcar resorption are problems that are seen in many long-term clinical series of total hip prostheses. In order to reduce the incidence of these problems, the goal of the designer of a prosthesis is to reduce cement and cement interface stresses around the femoral stem and to create stress distributions in the bone that will prevent resorption.(ABSTRACT TRUNCATED AT 250 WORDS)
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells (2011)

Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-wide profile of 5hmC in mouse embryonic stem (ES) cells. A combined analysis of global 5hmC distribution and gene expression profile in wild-type and Tet1-depleted ES cells suggests that 5hmC is enriched at both gene bodies of actively transcribed genes and extended promoter regions of Polycomb-repressed developmental regulators. Thus, our study reveals the first genome-wide 5hmC distribution in pluripotent stem cells, and supports its dual function in regulating gene expression.
Unifying mesh- and tree-based programmable interconnect (2004)

We examine the traditional, symmetric, Manhattan mesh design for field-programmable gate-array (FPGA) routing along with tree-of-meshes (ToM) and mesh-of-trees (MoT) based designs. All three networks can provide general routing for limited bisection designs (Rent's rule with p<1) and allow locality exploitation. They differ in their detailed topology and use of hierarchy. We show that all three have the same asymptotic wiring requirements. We bound this tightly by providing constructive mappings between routes in one network and routes in another. For example, we show that a (c,p) MoT design can be mapped to a (2c,p) linear population ToM and introduce a corner turn scheme which will make it possible to perform the reverse mapping from any (c,p) linear population ToM to a (2c,p) MoT augmented with a particular set of corner turn switches. One consequence of this latter mapping is a multilayer layout strategy for N-node, linear population ToM designs that requires only /spl Theta/(N) two-dimensional area for any p when given sufficient wiring layers. We further show upper and lower bounds for global mesh routes based on recursive bisection width and show these are within a constant factor of each other and within a constant factor of MoT and ToM layout area. In the process we identify the parameters and characteristics which make the networks different, making it clear there is a unified design continuum in which these networks are simply particular regions.
Internet of things: Toward smart networked systems and societies (2015)

Mark Underwood a, Michael Gruninger b, Leo Obrst c,∗, Ken Baclawski d, Mike Bennett e, Gary Berg-Cross f, Torsten Hahmann g and Ram Sriram h a Krypton Brothers, Port Washington, NY, USA b University of Toronto, Toronto, Canada c The MITRE Corporation, McLean, VA, USA d Northeastern University, Boston, MA, USA e Hypercube Ltd, London, UK f Knowledge Strategies, Washington, DC, USA g University of Maine, Orono, ME, USA h National Institute of Standards and Technology (NIST), Gaithersburg, MD, USA
Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophenDavid C. Dahlin and Sidney D. NelsonCite this: J. Med. Chem. 1982, 25, 8, 885–886Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/jm00350a001https://doi.org/10.1021/jm00350a001research-articleACS PublicationsRequest reuse permissionsArticle Views1431Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Large-Scale Production of Poly(3-Hydroxyoctanoic Acid) by <i>Pseudomonas putida</i> GPo1 and a Simplified Downstream Process (2008)

The suitability of Pseudomonas putida GPo1 for large-scale cultivation and production of poly(3-hydroxyoctanoate) (PHO) was investigated in this study. Three fed-batch cultivations of P. putida GPo1 at the 350- or 400-liter scale in a bioreactor with a capacity of 650 liters were done in mineral salts medium containing initially 20 mM sodium octanoate as the carbon source. The feeding solution included ammonium octanoate, which was fed at a relatively low concentration to promote PHO accumulation under nitrogen-limited conditions. During cultivation, the pH was regulated by addition of NaOH, NH(4)OH, or octanoic acid, which was used as an additional carbon source. Partial O(2) pressure (pO(2)) was adjusted to 20 to 40% by controlling the airflow and stirrer speed. Under the optimized conditions, P. putida GPo1 was able to grow to cell densities as high as 18, 37, and 53 g cells (dry mass) (CDM) per liter containing 49, 55, and 60% (wt/wt) of PHO, respectively. The resulting 40 kg CDM from these three cultivations was used directly for extraction of PHO. Three different methods of extraction of PHO were applied. From these, only acetone extraction showed better performance and resulted in 94% recovery of the PHO contents of cells. A novel mixture of precipitation solvents composed of 70% (vol/vol) methanol and 70% (vol/vol) ethanol was identified in this study. The ratio of PHO concentrate to the mixture was 0.2:1 (vol/vol) and allowed complete precipitation of PHO as white flakes. However, at a ratio of 1:1 (vol/vol) of the solvent mixture to PHO concentrate, a highly purified PHO was obtained. Precipitation yielded a dough-like polymeric material which was cast into thin layers and then shredded into small strips to allow evaporation of the remaining solvents. Gas chromatographic analysis revealed a purity of about 99% +/- 0.2% (wt/wt) of the polymer, which consisted mainly of 3-hydroxyoctanoic acid (96 mol%).
Efficient and scalable query routing for unstructured peer-to-peer networks (2005)

Searching for content in peer-to-peer networks is an interesting and challenging problem. Queries in Gnutella-like unstructured systems that use flooding or random walk to search must visit O(n) nodes in a network of size n, thus consuming significant amounts of bandwidth. In this paper, we propose a query routing protocol that allows low bandwidth consumption during query forwarding using a low cost mechanism to create and maintain information about nearby objects. To achieve this, our protocol maintains a lightweight probabilistic routing table at each node that suggests the location of each object in the network. Following the corresponding routing table entries, a query can reach the destination in a small number of hops with high probability. However, maintaining routing tables in a large and highly dynamic network requires non-traditional mechanisms. We design a novel data structure called an exponentially decaying bloom filter (EDBF) that encodes such probabilistic routing tables in a highly compressed manner, and allows for efficient aggregation and propagation. The search primitives provided by our system can be used to search for single keys or multiple keywords with equal ease. Analytical modeling of our design predicts significant improvements in search efficiency, verified through extensive simulations in which we observed an order of magnitude reduction in query path length over previous proposals.
Bamboo fiber reinforced polypropylene composites and their mechanical, thermal, and morphological properties (2010)

Abstract Short bamboo fiber reinforced polypropylene composites were prepared by incorporation of various loadings of chemically modified bamboo fibers. Maleic anhydride grafted polypropylene (MA‐ g ‐PP) was used as compatibilizer to improve fiber–matrix adhesion. The effects of bamboo fiber loading and modification of the resin on the physical, mechanical, thermal, and morphological properties of the bamboo reinforced modified PP composites were studied. Scanning electron microscopy studies of the composites were carried out on the interface and fractured surfaces. Thermogravimetric analysis and IR spectroscopy were also carried out. At 50% volume fraction of the extracted bamboo fiber in the composites, considerable increase in mechanical properties like impact, flexural, tensile, and thermal behavior like heat deflection temperature were observed. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Axotomized neonatal motoneurons overexpressing the bcl2 proto-oncogene retain functional electrophysiological properties. (1996)

Bcl2 overexpression prevents axotomy-induced neuronal death of neonatal facial motoneurons, as defined by morphological criteria. However, the functional properties of these surviving lesioned transgenic neurons are unknown. Using transgenic mice overexpressing the protein Bcl2, we have investigated the bioelectrical properties of transgenic facial motoneurons from 7 to 20 days after neonatal unilateral axotomy using brain-stem slices and whole cell patch-clamp recording. Nonaxotomized facial motoneurons from wild-type and transgenic mice had similar properties; they had an input resistance of 38 +/- 6 M omega and fired repetitively after injection of positive current pulses. When cells were voltage-clamped at or near their resting membrane potential, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartic acid (NMDA), or vasopressin generated sustained inward currents. In transgenic axotomized mice, facial motoneurons could be found located ipsilaterally to the lesion; they had an input resistance of 150 +/- 30 M omega, indicating that they were smaller in size, fired repetitively, and were also responsive to AMPA, NMDA, and vasopressin. Morphological measurements achieved 1 week after the lesion have shown that application of brain-derived neurotrophic factor prevented the reduction in size of axotomized transgenic motoneurons. These data indicate that Bcl2 not only prevents morphological apoptotic death of axotomized neonatal transgenic motoneurons but also permits motoneurons to conserve functional electrophysiological properties.
An Approach to 3D on the Web using Java OpenGL (2009)

Един подход към 3D в интернет с използване на Java OpenGL: Статията описва един подход за визуализация на тримерни сцени с използване на Java OpenGL и XML. Разгледани са няколко съществуващи технологии и са описани техните предимства и недостатъци. Предложен е формат базиран върху X3D и Open Inventor и е разработено Java приложение за визуализацията му. С негова помощ могат да се създават аплети за визуализация на тримерни обекти. Размерът на приложението е малък и зареждането му става достатъчно бързо. Изисква се на клиетна да е инсталиран единствено Java plugin за съответния браузер.
Induction of lactogenesis in transgenic virgin pigs: evidence for gene and integration site-specific hormonal regulation. (1992)

Five month-old transgenic female pigs from three lines carrying the mouse whey acidic protein (WAP) gene and nontransgenic female littermates were implanted with slow-release estrogen and progesterone pellets. Histological analysis of biopsies taken at the time of implantation and 4 weeks later revealed that mammary alveolar development had occurred upon hormonal stimulation in vivo. beta-Casein and beta-lactoglobulin mRNA was found in all induced animals, and WAP mRNA was detected in two of the three transgenic pigs. Differential hormonal regulation between the transgenes in the three lines and also between endogenous milk protein genes was observed in induced mammary tissue cultured in vitro. In the presence of insulin, hydrocortisone, and PRL, beta-casein and WAP mRNA levels increased in all transgenic pigs. In contrast, beta-lactoglobulin mRNA had reached or exceeded lactational levels in response to the in vivo induction, and no further increase was observed in vitro. This suggests that the regulation of the beta-lactoglobulin gene is distinct from that of beta-casein and WAP. Differences were also observed during pregnancy; whereas beta-lactoglobulin gene expression was induced in early pregnancy, a time when PRL levels are low, WAP mRNA levels increased sharply around parturition. Finally, the observation that hormonal regulation of WAP transgenes greatly differed between the three lines suggests that chromatin surrounding the integration site can modify the response of transcription elements.
Feline immunodeficiency virus can productively infect cultured endothelial cells from cat brain microvessels (1994)

Feline immunodeficiency virus (FIV) provokes a disease in cats characterized by histopathological lesions similar to those observed in AIDS patients. In order to determine whether endothelial cells from brain microvessels are involved in the central nervous system disease to the same extent as macrophages and microglia, cells were isolated from healthy cat brains, cultured and infected in vitro with the FIV Villefranche IFFA 1/88 strain. The isolated cells displayed typical endothelial cell ultrastructural features and were characterized further by von Willebrand factor-labelling and the binding of specific lectins such as Ulex europaeus lectin on their membrane. They were also able to take up acetylated low density lipoproteins. Two weeks after infection, significant amounts of FIV p24 antigen were detected by indirect immunofluorescence in syncytia and single cells. Concomitantly, the same antigen could be detected in the culture medium of the infected cells by an ELISA technique. Numerous viral particles as well as different steps in the process of viral budding were observed under transmission electron microscopy. The synthesis of FIV p24 antigens still occurred in cells in which replication was blocked in the G2 phase with taxol. Our results suggest the possibility of a productive infection of brain microvascular endothelial cells by FIV in vivo, which could lead to important perturbations in the functions of the blood-brain barrier.
Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin (2015)

Antigen-presenting cells have the remarkable capacity to transfer exogenous antigens to the cytosol for processing by proteasomes and subsequent presentation on major histocompatibility complex class-I (MHC-I) molecules, a process termed cross-presentation. This is the target of biomedical approaches that aim to trigger a therapeutic immune response. The receptor-binding B-subunit of Shiga toxin (STxB) has been developed as an antigen delivery tool for such immunotherapy applications. In this study, we have analyzed pathways and trafficking factors that are involved in this process. A covalent conjugate between STxB and saporin was generated to quantitatively sample the membrane translocation step to the cytosol in differentiated monocyte-derived THP-1 cells. We have found that retrograde trafficking to the Golgi complex was not required for STxB-saporin translocation to the cytosol or for STxB-dependent antigen cross-presentation. Depletion of endosomal Rab7 inhibited, and lowering membrane cholesterol levels favored STxB-saporin translocation. Interestingly, experiments with reducible and non-reducible linker-arm-STxB conjugates led to the conclusion that after translocation, STxB remains associated with the cytosolic membrane leaflet. In summary, we report new facets of the endosomal escape process bearing relevance to antigen cross-presentation.
Nanoparticles Secreted from Ivy Rootlets for Surface Climbing (2008)

Using atomic force microscopy, we observed ivy secretes nanoparticles through adhering disks of the ivy aerial rootlets which allow the plant to affix to a surface. We analyzed the organic composition of the secretions using high-performance liquid chromatography/mass spectrometry and were able to determine the formula of 19 compounds. This study suggests that the nanoparticles play a direct and important role for ivy surface "climbing". Weak adhesion and hydrogen bonding seem to be the forces for the climbing mechanism. This ivy secretion mechanism may inspire new methods for synthesizing nanoparticles biologically or new approaches to adhesion mechanisms for engineering applications.