gebhart/patrepeval huggingface dataset:
Promising new agents under development by the Division of Cancer Treatment, Diagnosis, and Centers of the National Cancer Institute. (1997)

The Division of Cancer Treatment, Diagnosis and Centers of the National Cancer Institute (NCI) has a large program in clinical cancer therapeutics development. It currently holds investigational new drug applications for nearly 200 agents with which it sponsors clinical trials. In addition, it has a major preclinical development program. With the tremendous advances in our understanding of molecular and tumor biology during the past decade, the NCI's portfolio of agents has expanded beyond classical cytotoxic agents to include a wide variety of new molecular and therapeutic targets. In addition to agents with more conventional mechanisms of action, the NCI has targeted therapeutics programs that focus on tumor vasculature, cell cycle control and cell signaling, mechanisms of apoptosis, invasion and metastasis, and immunological recognition and response. Each of these focused areas includes agents of different classes and modes of action that are all directed at the target of interest. The scope of the NCI's program allows it to respond to incorporate promising new agents or targets as they arise and to prioritize them for use of preclinical and clinical resources. Agents in development through the NCI are derived from a number of diverse sources including its own screening efforts, academia, and numerous collaborations with the pharmaceutical and biotechnology industries. NCI works closely with collaborators to ensure complementary, non-duplicative clinical development and attempts to ensure that the full potential of promising agents is explored. A number of compounds in early clinical development or about to enter the clinic are discussed briefly in this manuscript.
Periodic Mesoporous Organosilica with Large Heterocyclic Bridging Groups (2004)

Periodic mesoporous organosilica with a heterocyclic bridging group of large molecular weight, tris[3-(trimethoxysilyl)propyl]isocyanurate, is reported. Incorporation of an organic moiety into the silica framework afforded material attractive for adsorption of mercury and related heavy metal ions from aqueous solutions.
Mastering Wordperfect (1986)

The revised and expanded version of this definitive guide is now on WordPerfect 5 and covers word processing and basic desktop publishing. No tutorial approaches this one for clarity and depth of treatment. Sorting, line drawing, and laser printing are included.
Face-Down Solid Particle Receiver Using Recirculation (2011)

Solar thermal energy generation needs receiver technologies which can drive highly efficient turbines and decouple the collection of energy from its use by an economic storage technology. High-temperature solid particle receivers for solar tower systems with particle storage are one option. Important issues regarding high-temperature particle receivers are minimization of convective losses, no particle loss due to susceptibility to wind, and high efficiency also in part-load operation. A design approach facing these challenges is the face-down receiver using recirculation of particles. A screening performance analysis studying different recirculation patterns is presented. Using smart recirculation schemes, high receiver efficiencies can be maintained also at part-load operation (100% load ∼90%; 50% load ∼86%; 20% load ∼67%). Simulations of the face-down geometry yield total annual solar-to-electric efficiencies of 24% using a surround field. From the analyses, it can be concluded that solid particle receivers using smart recirculation patterns are a viable receiver option for storage and high-temperature high-efficiency turbine processes.
Enhanced 3-D-reconstruction algorithm for C-arm systems suitable for interventional procedures (2000)

Increasingly, three-dimensional (3-D) imaging technologies are used in medical diagnosis, for therapy planning, and during interventional procedures. We describe the possibilities of fast 3-D-reconstruction of high-contrast objects with high spatial resolution from only a small series of two-dimensional (2-D) planar radiographs. The special problems arising from the intended use of an open, mechanically unstable C-arm system are discussed. For the description of the irregular sampling geometry, homogeneous coordinates are used thoroughly. The well-known Feldkamp algorithm is modified to incorporate corresponding projection matrices without any decomposition into intrinsic and extrinsic parameters. Some approximations to speed up the whole reconstruction procedure and the tradeoff between image quality and computation time are also considered. Using standard hardware the reconstruction of a 256(3) cube is now possible within a few minutes, a time that is acceptable during interventions. Examples for cranial vessel imaging from some clinical test installations will be shown as well as promising results for bone imaging with a laboratory C-arm system.
Forensic DNA typing by the solid-phase minisequencing method (1993)

We describe a method for DNA-typing, in which a panel of biallelic markers are detected by the solid-phase minisequencing method (Syvänen et al., 1990). This method identifies single nucleotide variations in DNA fragments amplified by the PCR. Determination of the panel of 12 markers selected in this study proved to be an efficient and reliable method for forensic identification of individuals. We also introduce a novel approach for rapid determination of allele frequencies by quantitative analysis of pooled DNA samples.
The results of several acoustic telemetry tests in both shallow and deep water (2002)

The US Navy has a requirement for the transfer of data to and from underwater vehicles while submerged during training exercises. The required environments are diverse. Both midrange shallow water and midrange deep water areas will be used for training. In the deep water case, the system must be very cheap and expendable; in the shallow water case, it will be a permanently installed system. One of the goals of the Range Technology Development Program is the design, development, and testing of an acoustic telemetry system that will meet these needs. As a part of the design and development, phases of the program, several experiments in acoustic telemetry were done. A variety of different modulation and synchronization signals have been sent. The location of the testing includes deep water in the Bahamas, shallow water in Cape Cod Bay, Massachusetts, and shallow water off Block Island, Rhode Island. A summary of the results of these tests is presented.
Nickel‐Catalyzed CH Arylation of Azoles with Haloarenes: Scope, Mechanism, and Applications to the Synthesis of Bioactive Molecules (2011)

Novel nickel-based catalytic systems for the C-H arylation of azoles with haloarenes and aryl triflates have been developed. We have established that Ni(OAc)(2)/bipy/LiOtBu serves as a general catalytic system for the coupling with aryl bromides and iodides as aryl electrophiles. For couplings with more challenging electrophiles, such as aryl chlorides and triflates, the Ni(OAc)(2)/dppf (dppf = 1,1'-bis(diphenylphosphino)ferrocene) system was found to be effective. Thiazoles, benzothiazoles, oxazoles, benzoxazoles, and benzimidazoles can be used as the heteroarene coupling partner. Upon further investigation, we discovered a new protocol for the present coupling using Mg(OtBu)(2) as a milder and less expensive alternative to LiOtBu. Attempts to reveal the mechanism of this nickel-catalyzed heterobiaryl coupling are also described. This newly developed methodology has been successfully applied to the syntheses of febuxostat (a xanthine oxidase inhibitor that is effective for the treatment of gout and hyperuricemia), tafamidis (effective for the treatment of TTR amyloid polyneuropathy), and texaline (a natural product having antitubercular activity).
Inactivation of alanine racemase by .beta.-chloro-L-alanine released enzymically from amino acid and peptide C10-esters of deacetylcephalothin (1987)

The reactions of a set of amino acid and peptidyl C10-esters of deacetylcephalothin (1-5) have been examined with purified enzymes in vitro. Each of the compounds examined is a substrate for the Escherichia coli TEM-2 beta-lactamase, and enzyme-catalyzed hydrolysis of the lactam bond gives release of an amino acid or a peptidyl fragment from a cephem nucleus. 7 beta-(2-Thienylacetamido)-3-[[(beta-chloro-L-alanyl)oxy]methyl]-3- cephem-4-carboxylate (4) gives time-dependent inactivation of E. coli JSR-O alanine racemase in a process that requires beta-lactamase for the initial liberation of beta-chloro-L-alanine from the cephalosporin. Alanine racemase is similarly inactivated by 7 beta-(2-thienylacetamido)-3-[[[(beta-chloro-L-alanyl)-beta-chloro- L- alanyl]oxy]methyl]-3-cephem-4-carboxylate (1), but this inhibition requires the sequential action of both beta-lactamase and alanine aminopeptidase. Analysis of the enzymatic transformations of 7 beta-(2-thienylacetamido)-3-[[[(beta-chloro-L-alanyl)-L- alanyl]oxy]methyl]-3-cephem-4-carboxylate (3), monitored by high-field 1H NMR, reveals that (1) beta-lactamase releases the dipeptide beta-chloro-L-alanyl-L-alanine from 3 and (2) leucine aminopeptidase effects stoichiometric hydrolysis of the dipeptide to beta-chloro-L-alanine and L-alanine. These biochemical findings are discussed with reference to the mechanism of antibacterial action of 1 against beta-lactamase-producing, penicillin-resistant microorganisms [Mobashery, S., Lerner, S. A., & Johnston, M. (1986) J. Am. Chem. Soc. 108, 1685].
Sleep and Psychosomatic Medicine (2007)

1. Sleep and gastrointestinal functioning 2. Sleep and respiratory disorders 3. Sleep and coronary artery disease 4. Sleep and genitourinary systems 5. Sleep and depression: A functional neuroimaging perspective 6. Sleep alterations in schizophrenia 7. Sleep and neurological disorders 8. Behavioural interventions for sleep disorders 9. Medication effects on sleep 10. Sleep and personality disorders 11. A review of dreaming by psychiatric patients 12. Sleep and headache disorders 13. Sleep and infection 14. Narcolepsy 15. Sleep and stress 16. Sleep and attachment disorders in children 17. Animal modes of insomnia 18. Sleep deprivation as an antidepressant 19. Fibromyalgia and the neurobiology of sleep
Structural analysis of large digital circuits (1991)

Structural analysis of large circuits is very important for circuit design and test. The paper gives a generic structural model of large circuits and proposes a new concept of separated-cone. An algorithm is given to partition a circuit into separated-cones, and to find all the maximal-supergates in each separated-cone. After partitioning, the circuit fits for the generic structural model. This kind of partition is significant for design for testability, test generation, and fault simulation. It is interesting to explore the principle of hard-faults concentration, which means faults that are hard to detect are concentrated on a few separated-cones. Finally, the partitioning results of the 10 IS-CAS benchmark circuits are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Improved residue contact prediction using support vector machines and a large feature set (2007)

We describe SVMcon, a new contact map predictor that uses SVMs and a large set of informative features. SVMcon yields good performance on medium- to long-range contact predictions and can be modularly incorporated into a structure prediction pipeline.
Probing LaMO<sub>3</sub> Metal and Oxygen Partial Density of States Using X-ray Emission, Absorption, and Photoelectron Spectroscopy (2015)

We examined the electronic structure in LaMO<sub>3</sub> perovskite oxides (M = Cr, Mn, Fe, Co, Ni) by combining information from X-ray emission, absorption, and photoelectron spectroscopy. Through first-principles density functional theory simulations, we identified complementary hybridization features present in the transition metal and oxygen X-ray emission spectra. We then developed a method for the self-consistent alignment of the emission data onto a common energy scale using these features, providing a valuable supplementary technique to photoelectron spectroscopy for studying the partial density of states in perovskites. The combined information from X-ray emission and absorption was used to explore trends in electronic structure characteristics under the Zaanen–Sawatzky–Allen framework—namely the extent of metal–oxygen hybridization, band gap, and charge-transfer gap. We further established a method that allows for the experimental determination of the occupied and unoccupied band positions relative to the oxide Fermi level, as well as on an absolute energy scale.
T cell surface redox levels determine T cell reactivity and arthritis susceptibility (2006)

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to develop severe arthritis. These data suggest that ROS are involved in regulating the immune response. We now show that the lower capacity to produce ROS is associated with an increased number of reduced thiol groups (-SH) on T cell membrane surfaces. Artificially increasing the number of reduced thiols on T cells from animals with arthritis-protective Ncf1 alleles by glutathione treatment lowered the threshold for T cell reactivity and enhanced proliferative responses in vitro and in vivo. Importantly, T cells from immunized congenic rats with an E3-derived Ncf1 allele (DA.Ncf1E3 rats) that cannot transfer arthritis to rats with an arthritis-associated Dark Agouti (DA)-derived mutated Ncf1 allele (DA.Ncf1DA rats) became arthritogenic after increasing cell surface thiol levels. This finding was confirmed by the reverse experiment, in which oxidized T cells from DA.Ncf1DA rats induced less severe arthritis compared with controls. Therefore, we conclude that ROS production as controlled by Ncf1 is important in regulating surface redox levels of T cells and thereby suppresses autoreactivity and arthritis development.
Pinpointing genes underlying the quantitative trait loci for root-knot nematode resistance in palaeopolyploid soybean by whole genome resequencing (2013)

The objective of this study was to use next-generation sequencing technologies to dissect quantitative trait loci (QTL) for southern root-knot nematode (RKN) resistance into individual genes in soybean. Two hundred forty-six recombinant inbred lines (RIL) derived from a cross between Magellan (susceptible) and PI 438489B (resistant) were evaluated for RKN resistance in a greenhouse and sequenced at an average of 0.19× depth. A sequence analysis pipeline was developed to identify and validate single-nucleotide polymorphisms (SNPs), infer the parental source of each SNP allele, and genotype the RIL population. Based on 109,273 phased SNPs, recombination events in RILs were identified, and a total of 3,509 bins and 3,489 recombination intervals were defined. About 50.8% of bins contain 1 to 10 genes. A linkage map was subsequently constructed by using bins as molecular markers. Three QTL for RKN resistance were identified. Of these, one major QTL was mapped to bin 10 of chromosome 10, which is 29.7 kb in size and harbors three true genes and two pseudogenes. Based on sequence variations and gene-expression analysis, the candidate genes underlying the major QTL for RKN resistance were pinpointed. They are Glyma10g02150 and Glyma10g02160, encoding a pectin methylesterase inhibitor and a pectin methylesterase inhibitor -pectin methylesterase, respectively. This QTL mapping approach not only combines SNP discovery, SNP validation, and genotyping, but also solves the issues caused by genome duplication and repetitive sequences. Hence, it can be widely used in crops with a reference genome to enhance QTL mapping accuracy.
Paclitaxel pharmacodynamics: application of a mechanism‐based neutropenia model (2001)

Antineoplastic agents exert adverse effects that impact both dose and scheduling of drug administration. Our objective was to develop a quantitative relationship between paclitaxel (taxol) exposure and pharmacodynamic endpoints, such as neutropenia or body weight loss. Paclitaxel in liposomes or Cremophor EL was administered to rats at doses of 20 or 40 mg/kg. Body weight and absolute neutrophil count were determined daily. The decrease in body weight was greater for paclitaxel in Cremophor EL than for liposomal paclitaxel, but hematological toxicity was similar. The hematological data was fit using a pharmacodynamic model to investigate the temporal delay between drug exposure and neutropenia. From the model, the lifespan of neutrophils (T(N)), of surviving precursor cells in bone marrow (T(P)), and a killing rate constant (K) were determined. The values of T(N), T(P), and K for liposomal paclitaxel were 95 h, 82 h, and 0.735 (microM h)(-1), respectively, and for paclitaxel in Cremophor EL, 86 h, 78 h, and 0.475 (microM h)(-1), respectively. Simulations of various doses indicated a dependency of the neutropenia time course on paclitaxel exposure. The entire time course of changes in neutrophil count is more informative than a single measurement if myelosuppression is prolonged and at a level associated with increased incidence of clinical adverse effects.
A High-Definition Road-Network Model for Self-Driving Vehicles (2018)

High-definition (HD) maps have gained increasing attention in highly automated driving technology and show great significance for self-driving cars. An HD road network (HDRN) is one of the most important parts of an HD map. To date, there have been few studies focusing on road and road-segment extraction in the automatic generation of an HDRN. To improve the precision of an HDRN further and represent the topological relations between road segments and lanes better, in this paper, we propose an HDRN model (HDRNM) for a self-driving car. The HDRNM divides the HDRN into a road-segment network layer and a road-network layer. It includes road segments, attributes and geometric topological relations between lanes, as well as relations between road segments and lanes. We define the place in a road segment where the attribute changes as a linear event point. The road segment serves as a linear benchmark, and the linear event point from the road segment is mapped to its lanes via their relative positions to segment the lanes. Then, the HDRN is automatically generated from road centerlines collected by a mobile mapping vehicle through a multi-directional constraint principal component analysis method. Finally, an experiment proves the effectiveness of this HDRNM.
Cationic Polar Cycloaddition with Anodically Prepared a-Tri- and a-Difluoromethylated N,O-Acetals: Preparation of Fluoromethylated Tetra- and Dihydroquinoline Derivatives (1990)

Anodically prepared a-tri-and a-difluoromethylated Erg-acetals readily underwent [4++21 type polar cycloadditions with styrenes and phenylacetylene in the presence of a Lewis acid to provide the corresponding fluoromethylated tetra-and dihydroquinoline derivatives.In recent year, great interest has been paid to fluoro organic compounds, particularly tri-and difluoromethylated heterocyclic compounds because of their unique biological activities.'However, their synthetic methods are limited in many cases.For example, substitution with carbon-nucleophiles at a to a tri-+
Regulation of endothelial progenitor cell homing after arterial injury (2007)

Adult bone marrow and peripheral blood contain sub-populations of vascular precursor cells, which can differentiate into mature endothelial cells and have therefore been commonly termed endothelial progenitor cells (EPCs). Although EPCs encompass rather heterogeneous cell sub-populations of multiple origins and localization, these cells were basically characterized by expression of progenitor markers and by the development of colony-forming units and late endothelial outgrowth with terminal differentiation into mature endothelial cells. Notably, functional studies in vivo have implied the contribution of EPCs to therapeutic reendothelialization and inhibition of neointimal growth following endothelial injury. In the context of this regenerative arterial remodeling, an adequate homing of EPCs plays a central role. This multi-step process of EPC mobilization, recruitment and firm adhesion is regulated by key angiogenic chemokines (CCL2, CXCL1, CXCL7, CXCL12) and their respective receptors (CCR2, CXCR2, CXCR4). Furthermore, the recruitment of circulating EPCs to sites of arterial injury is synchronized by activated platelets and adhesion molecules of the selectin and integrin family. Thus, translating this molecular knowledge to interventional cardiovascular medicine, such a detailed understanding in the complex regulation of EPC homing may be helpful for more effectively preventing "in-stent" stenosis by facilitating stent endothelialization.
Standards of human comfort: relative and absolute (2009)

Student paper for Sustainable Design Seminar/Studio, Fall 2009. Instructors: Werner Lang and Wilfred Wang.
Annealing effect on laser pulse-induced THz wave emission in Ta/CoFeB/MgO films (2017)

Laser-induced terahertz (THz) emission in Ta/CoFeB/MgO films with various thicknesses of CoFeB and for various annealing temperatures was studied. The THz emission intensity exhibited its maximum value for a CoFeB layer thickness of approximately 1.0 nm, and this maximum value was enhanced by 1.5 times by annealing at 300 °C. A correlation was found in the annealing dependence between saturation magnetization, conductivity, and THz emission intensity. The origin of the enhancement of THz emission intensity due to annealing was discussed in terms of the increase in the mean free path of majority spin hot electrons in the CoFeB layer with crystallization due to the annealing.
High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model. (2003)

High-resolution magnetic resonance (MR) imaging techniques in a liver metastatic mouse model were used to assess CS-682, a novel 2'-deoxycytidine analogue of 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine. The efficacy of CS-682 was visualized in real time by MR imaging of initial seeding and subsequent growth of liver metastases. The relative therapeutic efficacies of CS-682 and two agents used clinically, gemcitabine [2'-deoxy-2',2'-difluorocytidine monohydrochloride (DFDC)] and 5-fluorouracil (5-FU), were compared in this model. CS-682 was found to exhibit superior efficacy by delaying the onset and inhibiting the growth of liver metastasis compared with gemcitabine, 5-FU, and control. The overall occurrence of metastases was decreased 62% by CS-682, 18% by DFDC, and 35% by 5-FU. CS-682 increased the life span of the treated animals significantly, by 28 days above the 29-day median survival without treatment, compared with 11 days by DFDC and 14 days by 5-FU. The increased survival in CS-682-treated animals correlated with the antimetastatic activity of this compound. These preclinical findings support the potential clinical utility of CS-682 in the treatment of liver metastasis.