gebhart/patrepeval huggingface dataset:
Topographic Organization of Baboon Primary Motor Cortex: Face, Hand, Forelimb, and Shoulder Representation (1990)

(1) The fine details of the motor organization of the forelimb, face, and tongue representation of the baboon (Papio h. anubis) primary motor cortex were studied in four adult animals, using intracortical microstimulation (ICMS). (2) A total of 293 electrode penetrations were made. ICMS was delivered to 10,052 sites, and of these, 6,186 sites were verified to have been located within the grey matter. Motor effects were evoked from 30% of these sites. (3) The baboon motor cortex is confined, in large part, to the cortical tissue lying along the anterior bank of the central sulcus. When the electrode penetrations were confined to the precentral gyrus, few sites were capable of evoking movement when stimulated by currents of 40 microA or less. (4) The details of the motor maps varied among the four animals; nonetheless, a general topographic organization existed, with the tongue musculature being represented most laterally, followed by a medial progression of the face, digits, wrist, forearm, and shoulder. Within the representation of a given body part, the muscles were organized as a mosaic, wherein the same muscle was multiply represented. (5) A zone of unresponsive cortex was observed to lie consistently between the face and forelimb representation in all four animals. Repeated electrode penetrations within the unresponsive zone failed to elicit muscle contractions even with stimulating currents as high as 80 microA. (6) Our results suggest that the baboon motor cortex is topographically organized; however, embedded within this overall pattern lies a fine-grained mosaic incorporating multiple representations of the same muscle.
Overview of high performance fibre-optic sensing (2004)

An overview of fibre-optic interferometry based sensing is given, particularly as it applies to high-performance sensing applications. The operation of a fibre-optic interferometer as a sensor is reviewed. The sensitivity limitations of a fibre-optic sensor are derived, and the system impact of multiplexing many sensors together is explored. A review of the development of the fibre-optic acoustic transducer is presented, as well as system applications and future trends in fibre-optic interferometric sensing.
How RISCy is DSP? (1992)

The characteristics of benchmark digital signal processing (DSP) algorithms are examined. These characteristics are used to suggest the features of an ideal DSP architecture, which is compared to current DSP and reduced instruction set computer (RISC) architectures. Timing comparisons taken from data books and research show that several on-the-market RISCs have a DSP performance close to or better than some DSP chips. Analysis of these DSP and RISC architectures leads to the suggestion of an ideal low-cost RISC DSP chip.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Why code complexity metrics fail on the C++ standard template library ∗ (2007)

Since McCabe’s cyclometric measure, structural complexity have been playing an important role measuring the complexity of programs. Complexity metrics are used to achieve more maintainable code with the least bugs possible. C++ Standard Template Library (STL) is the most popular library based on the generic programming paradigm. This paradigm allows implementation of algorithms and containers in an abstract way to ensure the configurability and collaboration of the abstract components. STL is widely used in industrial softwares because STL’s appropriate application decreases the complexity of the code significantly. Many new potential errors arise by the usage of the generic programming paradigm, including invalid iterators, notation of functors, etc. In this paper we present many complexity inconsistencies in the application of STL that a precise metric must take into account, but the existing measures ignore the characteristics of STL.
Axial-mode selectivities for various types of integrated twin-guide lasers (1977)

Wavelength dependencies of the gains, namely the axial-mode selectivities, of various types of integrated twin-guide (ITG) injection lasers are given theoretically. The double-resonator type, the distributed Bragg reflector (DBR), and the two tandem-connection types of ITG lasers are considered. The axial-mode selectivities are also discussed briefly in relation to the efficiencies.
Flywheel charging module for energy storage used in electromagnetic aircraft launch system (2005)

Optimal energy systems is currently designing and manufacturing flywheel based energy storage systems that are being used to provide pulses of energy for charging high voltage capacitors in a mobile military system. These systems receive their energy from low voltage vehicle bus power (<480 VDC) and provide output power at over 10,000 VDC without the need for DC-DC voltage conversion electronics. This energy conversion is accomplished through the use of OES patented ultra high-speed flywheel power module (FPoM) technology. In this paper, adaptation of the OES FPoM technology to energy storage for electromagnetic aircraft launch system (EMALS) applications is described. Physical system design parameters are summarized for the FPoM. Transient PSPICE electrical and MSC/Nastran FEA thermal analyses characterize operation and response in a conceptual EMALS energy storage environment.
New advances in ovarian cancer. (2010)

Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy in the United States, with approximately 15,000 deaths per year. Platinum/taxane doublets have long been considered the standard treatment regimen for advanced-stage disease; however, recent studies have sought to improve on the outcome from this therapy. Intraperitoneal (IP) chemotherapy has been shown to yield superior progression-free survival (PFS) and overall survival (OS); however, logistical problems and toxicities have limited more widespread adoption. Recent studies have also suggested that a "dose-dense" schedule of paclitaxel in combination with carboplatin may result in improved outcomes, and the impact of biological therapies in the first-line setting is under active investigation. In the setting of recurrent disease, preliminary results suggest that novel doublet regimens such as carboplatin and pegylated liposomal doxorubicin may have similar activity to standard platinum/taxane doublets while carrying a reduced risk of allergic reactions. Additionally, targeted therapy remains an active area of investigation, with evidence of activity from agents such as PARP inhibitors, anti-angiogenics, and PI3 kinase inhibitors. Here, we review recent advances in our understanding of ovarian cancer and its treatment in both the newly diagnosed and recurrent settings.
First Report of the Teleomorph of an <i>Oidium</i> sp. Causing Powdery Mildew on Flowering Dogwood in South Carolina (1999)

Prior to 1994, powdery mildew had rarely been reported on flowering dogwood (Cornus florida) in the southeastern U.S. That year, and every year since, epiphytotics of powdery mildew have occurred. Leaf symptoms include distortion and necrotic areas on young leaves and an increase in red pigmentation surrounding infection sites. Young seedlings may be stunted by this disease and growth of older trees may be slowed (2). In early November, 1996, dogwood (C. florida) trees at 10 locations each in Anderson, Oconee, and Pickens counties in northwestern South Carolina were surveyed for the presence of powdery mildew. Leaves with signs of powdery mildew (white, powdery patches of mycelium, conidiophores, and conidia) were examined with a ×10 hand lens and leaves with cleistothecia were collected and taken back to the laboratory. Numerous leaves from each site were first examined at ×50 on a dissecting microscope to observe gross morphological features of cleistothecia. Then, approximately 10 cleistothecia from each of two sites were examined on a compound microscope at ×100 or higher to make further observations and measurements. Cleistothecial diameter ranged from 75.0 to 92.5 μm (average 81.8 μm). Appendages, which averaged 6 to 11 per cleistothecium, were 110 to 140 μm long (average 125.7 μm) or 1.54 times the cleistothecial diameter. The apices of appendages were dichotomously branched 2 to 3 times and the tips were distinctly re-curved. The stalks were aseptate and hyaline. Cleistothecia contained 3 to 5 asci. Each ascus contained 2 to 6 ascospores measuring 18 to 28 × 13 to 15 μm. Based on these characteristics, the teleomorph was tentatively identified as Microsphaera pulchra. Cleistothecia were found to be slightly smaller and the number of appendages fewer than Braun's lectotype (1), but these differences were judged to be of minor importance. Therefore, we conclude that the teleomorph of the Oidium sp., herein reported on flowering dogwood for the first time in South Carolina, is Microsphaera pulchra References: (1) U. Braun. Nova Hedwigia 89:1, 1987. (2) L. A. Klein et al. Plant Dis. 82:383, 1998.
A Semantic Platform for Information Retrieval from E-Health Records. (2011)

Electronic patient health records encompass valuable information about patient’s medical problems, diagnoses, and treatments offered including their outcomes. However, a problem for medical professionals is an ability to efficiently access the information that are documented in the form of free-text. Therefore, the work presented here exhibits an information retrieval platform for efficient processing of e-health records. The system offers facilities for keyword searches, semantic searches, and ontological searches. An open evaluation during the TRECMED 2011 demonstrated competitive results.
Production and Characterization of Murine mAbs to the Extracellular Domain of Human Neu Oncogene Product GP185 <sup>HER2</sup> (1992)

The oncogene HER-2/neu encodes a transmembrane glycoprotein of 185 kDa (gp185HER-2) with tyrosine-kinase activity. Gene amplification and high levels of expression of gp185HER-2 have been found to correlate with poor clinical outcome in breast and ovarian carcinomas. Employing a somatic cell hybrid fusion protocol, which yields a high frequency production of hybridomas, we have analyzed the extent of the murine immune response to the gp 185 extracellular domain. In a single fusion experiment, using as immunogen NIH 3T3 cells expressing high levels of a transfected human HER-2 gene, we have generated mAbs, mainly of IgG1 isotype, displaying high affinity (10(7)-10(10) mol/L) to gp 185. Analysis of the epitope specificity has allowed the identification of five distinct groups of spatially related epitopes, each provided with different immunodominancy, and all resistant to formalin fixation. The use of inhibitor of N-linked glycosylation tunicamicyn has demonstrated that the mAbs bind to epitopes localized in the protein core of gp185HER-2. Because recent reports have shown that gp185HER-2 has a restricted expression in normal tissues and is homogenously detectable in metastatic foci of gp 185 + primary tumors, antibodies to this macromolecule, in addition to their prognostic value, may represent reagents for in vitro and in vivo diagnostic applications, as well as for the development of therapeutic strategies.
<i>Bacillus subtilis</i>Operon Encoding a Membrane Receptor for Bacteriophage SPP1 (2004)

The results reported here have identified yueB as the essential gene involved in irreversible binding of bacteriophage SPP1 to Bacillus subtilis. First, a deletion in an SPP1-resistant (pha-2) strain, covering most of the yueB gene, could be complemented by a xylose-inducible copy of yueB inserted at amyE. Second, disruption of yueB by insertion of a pMutin4 derivative resulted in a phage resistance phenotype regardless of the presence or absence of IPTG (isopropyl-beta-D-thiogalactopyranoside). YueB homologues are widely distributed in gram-positive bacteria. The protein Pip, which also serves as a phage receptor in Lactococcus lactis, belongs to the same family. yueB encodes a membrane protein of approximately 120 kDa, detected in immunoblots together with smaller forms that may be processed products arising from cleavage of its long extracellular domain. Insertional inactivation of yueB and the surrounding genes indicated that yueB is part of an operon which includes at least the upstream genes yukE, yukD, yukC, and yukBA. Disruption of each of the genes in the operon allowed efficient irreversible adsorption, provided that yueB expression was retained. Under these conditions, however, smaller plaques were produced, a phenotype which was particularly noticeable in yukE mutant strains. Interestingly, such reduction in plaque size was not correlated with a decreased adsorption rate. Overall, these results provide the first demonstration of a membrane-bound protein acting as a phage receptor in B. subtilis and suggest an additional involvement of the yukE operon in a step subsequent to irreversible adsorption.
Cyclic RGD‐Containing Functionalized Azabicycloalkane Peptides as Potent Integrin Antagonists for Tumor Targeting (2009)

Cyclic RGD-containing functionalized azabicycloalkane peptides were synthesized with the aim of developing high-affinity selective integrin ligands as carriers for therapeutic and diagnostic purposes. Herein we describe the synthesis and in vitro screening of these RGD derivatives, as well as the determination of their conformational properties in solution by spectroscopic and computational methods. Docking studies with the X-ray crystal structure of the extracellular domain of integrin alpha(v)beta(3) were also performed to elucidate the structural binding requirements and to rationalize the biological results. One compound in particular was found to be the best alpha(v)beta(3) integrin binder (IC(50)=53.7 nM) among the new functionalized RGD cyclic peptides, thus emerging as a promising candidate for covalent bonding and selective homing of useful functional units.
Nephron segment-specific gene expression using AAV vectors (2018)

AAV9 vector provides efficient gene transfer in all segments of the renal nephron, with minimum expression in non-renal cells, when administered retrogradely via the ureter. It is important to restrict the transgene expression to the desired cell type within the kidney, so that the physiological endpoints represent the function of the transgene expressed in that specific cell type within kidney. We hypothesized that segment-specific gene expression within the kidney can be accomplished using the highly efficient AAV9 vectors carrying the promoters of genes that are expressed exclusively in the desired segment of the nephron in combination with administration by retrograde infusion into the kidney via the ureter. We constructed AAV vectors carrying eGFP under the control of: kidney-specific cadherin (KSPC) gene promoter for expression in the entire nephron; Na<sup>+</sup>/glucose co-transporter (SGLT2) gene promoter for expression in the S1 and S2 segments of the proximal tubule; sodium, potassium, 2 chloride co-transporter (NKCC2) gene promoter for expression in the thick ascending limb of Henle's loop (TALH); E-cadherin (ECAD) gene promoter for expression in the collecting duct (CD); and cytomegalovirus (CMV) early promoter that provides expression in most of the mammalian cells, as control. We tested the specificity of the promoter constructs in vitro for cell type-specific expression in mouse kidney cells in primary culture, followed by retrograde infusion of the AAV vectors via the ureter in the mouse. Our data show that AAV9 vector, in combination with the segment-specific promoters administered by retrograde infusion via the ureter, provides renal nephron segment-specific gene expression.
Vertical cavity surface emitting lasers with InAs-InGaAs quantum dot active regions on GaAs substrates emitting at 1.3 μm (2002)

Pulsed lasing at 1.3 /spl mu/m via the exciton ground state is demonstrated for vertical cavity surface emitting lasers containing three uncoupled sheets of InAs quantum dot active layers. The dots lie within InGaAs quantum wells separated by GaAs barrier layers. The structures are grown on GaAs substrates and when fabricated include selectively oxidized AlO current apertures and AlO/GaAs distributed Bragg reflectors. Experimental devices operate pulsed at 20/spl deg/C with threshold currents below 2 mA and differential slope efficiencies of 40%.
Bayesian Model Selection in Social Research (1995)

It is argued that P-values and the tests based upon them give unsatisfactory results, especially in large samples. It is shown that, in regression, when there are many candidate independent variables, standard variable selection procedures can give very misleading results. Also, by selecting a single model, they ignore model uncertainty and so underestimate the uncertainty about quantities of interest. The Bayesian approach to hypothesis testing, model selection, and accounting for model uncertainty is presented. Implementing this is straightforward through the use of the simple and accurate BIC approximation, and it can be done using the output from standard software. Specific results are presented for most of the types of model commonly used in sociology. It is shown that this approach overcomes the difficulties with P-values and standard model selection procedures based on them. It also allows easy comparison of nonnested models, and permits the quantification of the evidence for a null hypothesis of interest, such as a convergence theory or a hypothesis about societal norms.
INTERROGATORIES (1987)

The suggestions included in this manuscript are my opinion and are submitted to stimulate thought. Since there is a difference in law and nurse practice acts from state to state, any particularity should be discussed with the institution's legal counsel.
Theory of Magnetic Effects on the Noise in a Germanium Filament (1953)

A magnetic field will influence the current noise in a germanium filament. This fact bears out the hypothesis that at least part of the noise arises from minority carriers emitted in random bursts and recombining at the surfaces. A quantitative theory of this effect is given.
Absorption spectra, electrochemical behavior, luminescence spectra, and excited-state lifetimes of mixed-ligand ortho-metalated rhodium(III) complexes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbsorption spectra, electrochemical behavior, luminescence spectra, and excited-state lifetimes of mixed-ligand ortho-metalated rhodium(III) complexesMauro Maestri, Diana Sandrini, Vincenzo Balzani, Urs Maeder, and Alex Von ZelewskyCite this: Inorg. Chem. 1987, 26, 8, 1323–1327Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ic00255a025https://doi.org/10.1021/ic00255a025research-articleACS PublicationsRequest reuse permissionsArticle Views400Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Concurrent downregulation of a glutamate transporter and receptor in glaucoma. (2000)

The loss of EAAT1 in glaucoma may account for the elevated level of glutamate found in glaucomatous vitreous and lead to a compensatory downregulation of NMDAR1. Inasmuch as GDNF can increase levels of both EAAT1 and NMDAR1, it may be a useful therapeutic approach to restore homeostatic levels of these in glaucoma.
The congruity principle and television commercials (1962)

A point that is often overlooked is that “who” says something, or “how” it is said, is as important as “what” is being said—and vice versa. Some years ago, Tannenbaum and Osgood (at the University of Illinois) developed what was called the “congruity principle” to provide a predictive model for linking these factors. The field of attitude measurement in which they worked is closely allied to the persuasive purposes of advertising. The following use of relatively sophisticated research techniques should be of particular interest to those in the field of mass consumer persuasion who have heretofore considered “attitudes” or “images” and the various techniques of advertising as separate concepts, whose possible interrelationships need not be considered.
Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins (1996)

A major physiological role of insulin is the regulation of glucose uptake into skeletal and cardiac muscle and adipose tissue, mediated by an insulin-stimulated translocation of GLUT4 glucose transporters from an intracellular vesicular pool to the plasma membrane. This process is similar to the regulated docking and fusion of vesicles in neuroendocrine cells, a process that involves SNARE-complex proteins. Recently, several SNARE proteins were found in adipocytes: vesicle-associated membrane protein (VAMP-2), its related homologue cellubrevin, and syntaxin-4. In this report we show that treatment of permeabilized 3T3-L1 adipocytes with botulinum neurotoxin D, which selectively cleaves VAMP-2 and cellubrevin, inhibited the ability of insulin to stimulate translocation of GLUT4 vesicles to the plasma membrane. Furthermore, treatment of the permeabilized adipocytes with glutathione S-transferase fusion proteins encoding soluble forms of VAMP-2 or syntaxin-4 also effectively blocked insulin-regulated GLUT4 translocation. These results provide evidence of a functional role for SNARE-complex proteins in insulin-stimulated glucose uptake and suggest that adipocytes utilize a mechanism of regulating vesicle docking and fusion analogous to that found in neuroendocrine tissues.