gebhart/patrepeval huggingface dataset:
Unique immunologic patterns in fibromyalgia (2012)

The cytokine responses to mitogenic activators of PBMC isolated from patients with FM were significantly lower than those of healthy individuals, implying that cell-mediated immunity is impaired in FM patients. This novel cytokine assay reveals unique and valuable immunologic traits, which, when combined with clinical patterns, can offer a diagnostic methodology in FM.
Efficient health data compression on mobile devices (2013)

There is an increase rise in the usage of mobile health sensors in wearable devices and smartphones. These embedded systems have tight limits on storage, computation power, network connectivity and battery usage making it important to ensure efficient storage/ communication of sensor readings to centralized node/ server. Frequency Transform or Entropy encoding schemes such as arithmetic or Huffman coding can be used for compression, but they incur high computational cost in some scenarios or are oblivious to the higher level redundancies in signal. To this end, we used the property of periodicity in these naturally occurring signals such as heart rate or gait measurements to design a simple low cost scheme for data compression. First, a modified Chi-square periodogram metric is used to adaptively determine the exact time-varying periodicity of the signal. Next, the time-series signal is folded into Frames of length equal to a pre-determined period value. We have successfully tested the scheme for good compression performance in ECG, motion accelerometer data and Parkinson patients samples, leading to 8-14X compression in large sample sizes (6-8K samples) and 2-3X in small sample sizes (200 samples). The proposed scheme can be used stand-alone or as pre-processing step for existing techniques in literature.
Ultrastructural Aspects of Acetylcholine Receptor Turnover at the Normal End-plate and in Autoimmune Myasthenia Gravis (1982)

Acetylcholine receptor (AChR) deficiency at the myasthenic end-plate has been attributed to complement-mediated lysis of the junctional folds and to increased fractional degradation rate of AChR cross-linked by myasthenic immunoglobulin. This paper addresses the manner in which AChR is internalized and degraded at the normal end-plate and provides morphologic evidence for accelerated AChR degradation at the end-plate of rats with experimental autoimmune myasthenia gravis (EAMG). We sequentially traced the fate of end-plate AChR labeled in vivo with intramuscularly-injected peroxidase-alpha-bungarotoxin (PBGT) in control rats and rats with chronic EAMG. At both control and EAMG end-plates, AChR is internalized by endocytosis. The endocytosed vesicles containing AChR are transferred into the lysosomal compartment which extends from the junctional folds into the junctional sarcoplasm. Regardless of whether the initial intensity of the reaction for AChR at the EAMG end-plate appeared normal or reduced. AChR disappeared more rapidly from the EAMG than from the control end-plates. Despite the accelerated fractional turnover rate of end-plate AChR in EAMG, the postsynaptic membrane surface which could be labeled with PBGT for AChR remained unchanged over a 120-hour period. These data suggest that end-plate AChR is at a steady state in chronic EAMG.
Full Scale Coated Fiber Neutron Detector Measurements (2010)

Radiation portal monitors used for interdiction of illicit materials at borders include highly sensitive neutron detection systems. The main reason for having neutron detection capability is to detect fission neutrons from plutonium. The currently deployed radiation portal monitors (RPMs) from Ludlum and Science Applications International Corporation (SAIC) use neutron detectors based upon 3He-filled gas proportional counters, which are the most common large neutron detector. There is a declining supply of 3He in the world, and thus, methods to reduce the use of this gas in RPMs with minimal changes to the current system designs and sensitivity to cargo-borne neutrons are being investigated. Four technologies have been identified as being currently commercially available, potential alternative neutron detectors to replace the use of 3He in RPMs. These technologies are: 1) Boron trifluoride (BF3)-filled proportional counters, 2) Boron-lined proportional counters, 3) Lithium-loaded glass fibers, and 4) Coated non-scintillating plastic fibers. Reported here are the results of tests of the full-scale 6Li/ZnS(Ag)-coated non-scintillating plastic fibers option. This testing measured the required performance for neutron detection efficiency and gamma ray rejection capabilities of a system manufactured by Innovative American Technology (IAT) and Saint Gobain, and is a follow-up report to an earlier one on a smaller prototype system.
Synthesis and antibacterial activity of a new series of tetracyclic pyridone carboxylic acids (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antibacterial activity of a new series of tetracyclic pyridone carboxylic acidsYoshikazu Jinbo, Hirosato Kondo, Yoshimasa Inoue, Masahiro Taguchi, Hideki Tsujishita, Yasuo Kotera, Fumio Sakamoto, and Goro TsukamotoCite this: J. Med. Chem. 1993, 36, 18, 2621–2626Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jm00070a005https://doi.org/10.1021/jm00070a005research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Water holding capacity characteristic of ground cover and soil under pure Abies fabri forest on the Gongga Mountain (2002)

In order to study the effect of ground cover and forest soil under Abies fabri forest on the Gongga Mountain (29°20^～30°20^N, 101°30^～102°15^E) on soil and water conservation and water source conservation, the authors got hydrological characteristic parameters such as the maximum water holding capacity, water absorption speed of ground cover and physical characteristic parameters such as the total porosity, the capillary porosity of the forest soil through the water holding characteristic experiment of the ground cover and the forest soil experiment under four types of Abies fabri forest (the young stand, the mid-age stand, the mature stand and the overmature stand). The result shows that the maximum water holding capacity of the moss under the mature stand is the maximal, which is 343.5% of its dry weight, that of the moss under the overmature stand is 284.5%, that of the moss under the mid-age stand is 282.5%, that of the moss under the young stand is 250%. The maximum water holding capacity of the litter under the mature stand is 301.8% of its dry weight, that of the litter under the overmature stand is 226.4%, that of the litter under the mid-age stand is 209.4%, that of the litter under the young stand is 205.4%. The equation between the water absorption speed of the ground cover and the immersing time is S = kt~n. The density of the forest soil on the Gongga Mountain is 0.851～1.136 g/cm~3, the saturated capacity is 55.29%～83.96%, the capillary holding capacity is 44.48%～75.41%. The field holding capacity is 39.50%～65.86%.
Plasma Treatment for Painting of Polypropylene Bumper (1985)

<div class="htmlview paragraph">The colour painting of polypropylene bumpers has required development of a new polypropylene surface treatment which provides improved adhesion of the paint film to polypropylene.</div> <div class="htmlview paragraph">According to the results of various improvement studies on the application of plasma treatment, it has been discovered that surface treatment by means of plasma of an oxygen and nitrogen gas mixture activated by microwave (2,450 MHz) provides a remarkable improvement in adhesion.</div> <div class="htmlview paragraph">Furthermore, establishing a technique to diffuse plasma effectively within the treatment chamber has enabled a uniform surface treatment of several polypropylene bumpers formed in large and complicated shapes.</div>
Achieving Extremely Concentrated Aqueous Dispersions of Graphene Flakes and Catalytically Efficient Graphene-Metal Nanoparticle Hybrids with Flavin Mononucleotide as a High-Performance Stabilizer (2015)

The stable dispersion of graphene flakes in an aqueous medium is highly desirable for the development of materials based on this two-dimensional carbon structure, but current production protocols that make use of a number of surfactants typically suffer from limitations regarding graphene concentration or the amount of surfactant required to colloidally stabilize the sheets. Here, we demonstrate that an innocuous and readily available derivative of vitamin B2, namely the sodium salt of flavin mononucleotide (FMNS), is a highly efficient dispersant in the preparation of aqueous dispersions of defect-free, few-layer graphene flakes. Most notably, graphene concentrations in water as high as ∼50 mg mL(-1) using low amounts of FMNS (FMNS/graphene mass ratios of about 0.04) could be attained, which facilitated the formation of free-standing graphene films displaying high electrical conductivity (∼52000 S m(-1)) without the need of carrying out thermal annealing or other types of post-treatment. The excellent performance of FMNS as a graphene dispersant could be attributed to the combined effect of strong adsorption on the sheets through the isoalloxazine moiety of the molecule and efficient colloidal stabilization provided by its negatively charged phosphate group. The FMNS-stabilized graphene sheets could be decorated with nanoparticles of several noble metals (Ag, Pd, and Pt), and the resulting hybrids exhibited a high catalytic activity in the reduction of nitroarenes and electroreduction of oxygen. Overall, the present results should expedite the processing and implementation of graphene in, e.g., conductive inks, composites, and hybrid materials with practical utility in a wide range of applications.
Stress softening in natural rubber vulcanizates. Part III. Carbon black‐filled vulcanizates (1966)

Abstract Stress softening (Mullins effect) occurs in rubber vulcanizates during the first and subsequent deformations. This paper shows the similarity of the degree of stress softening in both unfilled and carbon black‐filled vulcanizates of natural rubber when stressed almost to break. This confirms the earlier investigations which were confined to moderate stresses. A simple interpretation of the tensile stress–strain results for filled rubber is that the strain in the rubber is increased by the presence of the filler, so that the ratio of the average strain in the rubber to the measured overall strain is given by a strain amplification factor. The usefulness of this concept is confirmed by showing the similarity of the stress‐softened curves after normalizing the strains, provided the vulcanizates of both gum and filled vulcanizates were subjected to the same initial stress.
Optical/Electrical Hybrid Switching for Datacenter Communications (2013)

We discuss optical/electrical hybrid switching for datacenters. Our current prototype uses an optical circuit switched architecture based on a wavelength-selective switch (WSS) that has a measured mean host-to-host network reconfiguration time of 11.5 μs.
Safety Factors Relating to Monitored Compactor Operating Parameters (1998)

Abstract Recent NIOSH fatality investigations have shown that workers risk amputation and crush injury while attempting to clear jammed material from the loading chambers and feed chutes of operating baling and compacting equipment. A recent NIOSH study suggests that signals generated by strain gage transducers could be used to warn of impending jams. Strain gages placed at locations on the machine’s frame experiencing large deformations preceding jams would be used to trigger a visual or audible alarm. A system safety analysis using FaultrEASE software was conducted to describe the sources of variation in operating conditions that could confound the transducer response of the proposed safety device. Monitoring will require adequate signal conditioning to adjust for the effects of temperature differentials, vibration, electromagnetic interference, and other factors present in the indoor and outdoor operating environments typical for these machines. An experimental study was also conducted. Readings were collected from strain gages bonded to an integral horizontal compactor container. Readings were taken once a day as the compactor was normally being filled. Independent variables included: gage site; gage length; relative amount of compactor fill; and gage orientation. The dependent variable was strain gage voltage response under normal compactor cycling. The strains that were indicated were clearly biaxial and dynamic. Varying gage length and location produced significantly different responses. Substantial changes in gage response were recorded as material volume increased in the container. Mechanical blocking of the platen and proper lockout/tagout should remain the primary control of hazardous energy to prevent baling-equipment-related amputation and crushing injury.
TICK-BORNE RICKETTSIAE OF THE SPOTTED FEVER GROUP IN WEST PAKISTAN (1973)

Journal Article TICK-BORNE RICKETTSIAE OF THE SPOTTED FEVER GROUP IN WEST PAKISTAN: II. SEROLOGICAL CLASSIFICATION OF ISOLATES FROM WEST PAKISTANAN AND THAILAND: EVIDENCE FOR TWO NEW SPECIES Get access RICHARD G. ROBERTSON, RICHARD G. ROBERTSON 1Research Associate, Institute of International Medicine, University of Maryland Medical SchoolBaltimore Search for other works by this author on: Oxford Academic PubMed Google Scholar CHARLES L. WISSEMAN, JR CHARLES L. WISSEMAN, JR 2 2Requests for reprints should be sent to: Charles L. Wisseman, Jr., MI Department of Micro biology, School of Medicine, University of Mary land, 660 W. Redwood Street, Baltimore, Mary land 21201 Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 97, Issue 1, January 1973, Pages 55–64, https://doi.org/10.1093/oxfordjournals.aje.a121485 Published: 01 January 1973 Article history Received: 03 October 1972 Published: 01 January 1973
Research on Extended Expansion General-Purpose EngineTheoretical Analysis of Multiple Linkage System and Improvement of Thermal Efficiency (2006)

<div class="htmlview paragraph">Research has been conducted on an extended expansion engine, using a multiple linkage system to increase the thermal efficiency of general-purpose engines. A four-jointed linkage was used between the connecting rod and the crank pin of a standard piston-crank system. The end of the linkage rotates at half the speed of the crankshaft, resulting in piston strokes unequal length in each revolution. The length of the expansion stroke is greater than that of the compression stroke, thereby providing an extended expansion cycle. This thermal cycle is just Atkinson cycle, and precisely different from Miller cycle, which often required supercharging or variable valve timing control system.</div> <div class="htmlview paragraph">Theoretical thermal efficiency and numerical simulations were used to determine the increase in thermal efficiency at a compression ratio of 8.5 and an expansion ratio of 12.3. The results show that this extended expansion increases indicated thermal efficiency 4.0% against a conventional engine, from 27.3 to 31.3%. In addition, the new design displayed increases of 2.0 and 2.7% in indicated thermal efficiency against naturally aspirated Miller cycle engines with early valve closure and late valve closure, respectively.</div> <div class="htmlview paragraph">An air-cooled single-cylinder engine equipped with this mechanism was constructed and its thermal efficiency was compared in tests against a conventional engine in the same power class. The results of these tests matched the simulation results almost exactly, with the new engine displaying 4.1% higher indicated thermal efficiency and 5.0% higher break thermal efficiency than in the conventional engine..</div> <div class="htmlview paragraph">Using this system, it can be achieved to improve thermal efficiency without increasing the compression ratio which lead to knocking. This system is well suited to air-cooled general-purpose engines operated under the continuous high loads and may often operated by low-octane fuels in developing country.</div>
Humoral immune responses against Wilms tumor gene WT1product in patients with hematopoietic malignancies (2002)

Wilms tumor gene WT1 is expressed at high levels in hematopoietic malignancies, such as leukemias and myelodysplastic syndromes (MDS), and in various kinds of solid tumors, including lung cancer, and it exerts an oncogenic function in these malignancies. IgM and IgG WT1 antibodies were measured by means of dot blot assay in 73 patients with hematopoietic malignancies (16 acute myeloid leukemia [AML], 11 acute lymphoid leukemia [ALL], 13 chronic myeloid leukemia [CML], and 33 MDS) and 43 healthy volunteers. Immunoglobulin IgM, IgG, and IgM+IgG WT1 antibodies were detected in 40 (54.8%), 40 (54.8%), and 24 (32.8%), respectively, of the 73 patients with hematopoietic malignancies, whereas 7 (16.2%), 2 (4.7%), and none of the 43 healthy volunteers had IgM, IgG, or IgM+IgG WT1 antibodies, respectively. Furthermore, immunoglobulin isotype class switching of WT1 antibodies from IgM to IgG occurred in conjunction with disease progression from refractory anemia (RA) to RA with excess of blasts (RAEB), and further to RAEB in transformation (RAEB-t) in MDS patients. These results showed that humoral immune responses against the WT1 protein could be elicited in patients with WT1-expressing hematopoietic malignancies, and they suggested that the helper T-cell responses needed to induce humoral immune responses and immunoglobulin isotype class switching from IgM to IgG were also generated in these patients. Our findings may provide new insight into the rationale for elicitation of cytotoxic T-cell responses against the WT1 protein in cancer immunotherapy using the WT1 vaccine.
Photothermally Sensitive Poly(<i>N</i>‐isopropylacrylamide)/Graphene Oxide Nanocomposite Hydrogels as Remote Light‐Controlled Liquid Microvalves (2012)

Abstract A photothermally sensitive poly( N ‐isopropylacrylamide)/graphene oxide (PNIPAM/GO) nanocomposite hydrogel can be synthesized by in situ γ‐irradiation‐assisted polymerization of an aqueous solution of N ‐isopropylacrylamide monomer in the presence of graphene oxide (GO). The colors and phase‐transition temperatures of the PNIPAM/GO hydrogels change with different GO doping levels. Due to the high optical absorbance of the GO, the nanocomposite hydrogel shows excellent photothermal properties, where its phase transitions can be controlled remotely by near‐infrared (NIR) laser irradiation, and it is completely reversible via laser exposure or non‐exposure. With a higher GO loading, the NIR‐induced temperature of the nanocomposite hydrogel increases more quickly than with a lower doping level and the temperature can be tuned effectively by the irradiation time. The nanocomposite hydrogel with its excellent photothermal properties will have great applications in the biomedical field, especially as microfluidic devices; this has been demonstrated in our experiments by way of remote microvalves to control fluidic flow. Such an “easy” and “clean” synthetic procedure initiated by γ‐irradiation can be extended for the efficient synthesis of other nanocomposite materials.
Modulation spectroscopy at non-normal incidence with emphasis on the vacuum-uv spectral region (1976)

Expressions are given to analyze modulation spectra taken at non-normal incidence. These expressions are used to determine the optimum angle of incidence to maximize the signal-to-noise ratio. Significant improvements are shown to be obtained in the vacuum-uv spectral region by making measurements at relatively large angles of incidence. We apply these expressions to evaluate the field-induced change in the dielectric function for the 20.5–21.0-eV core-level doublet in GaP from Schottky-barrier electroreflectance data. The line shape obtained is consistent with that of a field-modulated M0 critical point modified by a Coulomb attraction between the core hole and the excited electron.
Expression of neoplasia-related proteins of chemically transformed HuT fibroblasts in human osteosarcoma HOS fibroblasts and modulation of actin expression upon elevation of tumorigenic potential. (1985)

Two sets of abundant cytoplasmic transformation-specific polypeptides, p788/p789 and p219/p220, have been identified by comparing in vitro-transformed human fibroblasts with diploid human fibroblasts. These polypeptides are also expressed by the human fibrosarcoma and osteosarcoma cell lines HT1080 the human fibrosarcoma and osteosarcoma cell lines HT1080 and HOS, respectively. HOS cells, however, synthesize only one of the two electrophoretic forms of each marker set, p789 and p219, at greatly reduced rates compared to the rates of synthesis found for HT1080 cells and the in vitro-transformed cell lines. Induction of expression of these neoplastic marker polypeptides is independent of the activation of a transforming gene that will induce focus formation in confluent mouse 3T3 cell monolayers. Activation of the met oncogene in MNNG-HOS cells and simultaneous elevation of tumorigenic potential did not lead to a significant change in the rate of the 600 most abundant polypeptide species with the exception of one of the two cytoplasmic actin polypeptides. While the normal ratio of beta-to gamma-actin which is approximately 2:1 was expressed in "untransformed" HOS cells, MNNG-HOS cells synthesized 50% less beta-actin resulting in a 1:1 ratio of beta-actin to gamma-actin. Our finding here, together with our previous characterization of the human beta-actin gene, leads us to predict that one of two functional beta-actin genes expressed in HOS cells has been inactivated in MNNG-HOS cells by either a regulatory or structural gene mutation.