gebhart/patrepeval huggingface dataset:
Near‐Infrared SERS Nanoprobes with Plasmonic Au/Ag Hollow‐Shell Assemblies for In Vivo Multiplex Detection (2013)

Abstract For the effective application of surface‐enhanced Raman scattering (SERS) nanoprobes for in vivo targeting, the tissue transparency of the probe signals should be as high as it can be in order to increase detection sensitivity and signal reproducibility. Here, near‐infrared (NIR)‐sensitive SERS nanoprobes (NIR SERS dots) are demonstrated for in vivo multiplex detection. The NIR SERS dots consist of plasmonic Au/Ag hollow‐shell (HS) assemblies on the surface of silica nanospheres and simple aromatic Raman labels. The diameter of the HS interior is adjusted from 3 to 11 nm by varying the amount of Au 3+ added, which results in a red‐shift of the plasmonic extinction of the Au/Ag nanoparticles toward the NIR (700–900 nm). The red‐shifted plasmonic extinction of NIR SERS dots causes enhanced SERS signals in the NIR optical window where endogenous tissue absorption coefficients are more than two orders of magnitude lower than those for ultraviolet and visible light. The signals from NIR SERS dots are detectable from 8‐mm deep in animal tissues. Three kinds of NIR SERS dots, which are injected into live animal tissues, produce strong SERS signals from deep tissues without spectral overlap, demonstrating their potential for in vivo multiplex detection of specific target molecules.
OSCAR Testing with Xen (2006)

The development of new OSCAR packages and of new releases is difficult because of the testing required for the ever growing set of supported Linux distributions. Each time, a new cluster has to be setup, including the full installation of the headnode system. At the same time, some paravirtualization software, like Xen, allows one to create a set of virtual machines on a single physical machine. Therefore, the use of Xen for cluster virtualization and OSCAR testing may be interesting. This document presents Xen-OSCAR, a framework based on Xen, which aims at providing a solution to create a virtual OSCAR cluster.
Evaluation of the Pharmacodynamic Effects of MGCD0103 from Preclinical Models to Human Using a Novel HDAC Enzyme Assay (2008)

This study shows that MGCD0103 has sustained pharmacodynamic effects that can be monitored both in vitro and in vivo with a cell-based HDAC enzyme assay.
Fast methods for the Eikonal and related Hamilton– Jacobi equations on unstructured meshes (2000)

The Fast Marching Method is a numerical algorithm for solving the Eikonal equation on a rectangular orthogonal mesh in O(M log M) steps, where M is the total number of grid points. The scheme relies on an upwind finite difference approximation to the gradient and a resulting causality relationship that lends itself to a Dijkstra-like programming approach. In this paper, we discuss several extensions to this technique, including higher order versions on unstructured meshes in Rn and on manifolds and connections to more general static Hamilton-Jacobi equations.
A conceptual modeling approach for web service composition supporting service re-configuration (2010)

Service composition is a recent field that has seen a flurry of different approaches proposed towards the goal of flexible distributed heterogeneous interoperation of software systems, usually based on the expectation that such systems must be derived from higher level models rather than be coded at low level. We propose a conceptual modelling approach for the composition of service processes into a task workflow and its dynamic adaption to changes during runtime. The contribution of the paper is twofold. Firstly, our approach improves on existing approaches by the separation of configuration into service configuration and service instance configuration which reduces the reconfiguration cycles in case of changes and secondly, we describe a comprehensive modelling concept that combines existing dynamic composition techniques in a novel way.
Multiuser Constrained Water-Pouring for Continuous-Time Overloaded Gaussian Multiple-Access Channels (2008)

In this paper, signature waveforms and signal powers are jointly optimized for multiuser communications over strictly bandlimited, continuous-time, overloaded channels corrupted by additive white Gaussian noise (AWGN). The total signal power is minimized subject to general asymmetric signal-to-interference-plus-noise ratio (SINR) constraints at the output of linear minimum mean-squared error (LMMSE) receivers. Using vectorized Fourier transform (VFT) technique, the optimal solutions as well as a necessary and sufficient condition for the existence of a feasible solution are derived in the frequency domain. It turns out that every optimal solution performs the same as the optimal frequency-division multiple-access (FDMA) system. A geometric procedure called multiuser constrained water-pouring is developed to construct every possible optimal solution, of which profiles of signal power and equivalent bandwidth are, respectively, the same as those of signal power and physical bandwidth of the optimal FDMA system. It is shown that orthogonal signature waveforms are assigned to oversized users and continuous-time equivalents of generalized Welch bound equality (CTE-GWBE) sequences are assigned to non-oversized users.
Preparation of .beta.-oxo aldehydes by acylation of aldehyde enamines (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of .beta.-oxo aldehydes by acylation of aldehyde enaminesTakashi Inukai and Ryo YoshizawaCite this: J. Org. Chem. 1967, 32, 2, 404–407Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/jo01288a032https://doi.org/10.1021/jo01288a032research-articleACS PublicationsRequest reuse permissionsArticle Views805Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Directional ringlet intensity feature transform for tracking (2015)

The challenges existing for current intensity-based histogram feature tracking methods in wide area motion imagery include object structural information distortions and background variations, such as different pavement or ground types. All of these challenges need to be met in order to have a robust object tracker, while attaining to be computed at an appropriate speed for real-time processing. To achieve this we propose a novel method, Directional Ringlet Intensity Feature Transform (DRIFT), that employs Kirsch kernel filtering and Gaussian ringlet feature mapping. We evaluated the DRIFT on two challenging datasets, namely Columbus Large Image Format (CLIF) and Large Area Image Recorder (LAIR), to evaluate its robustness and efficiency. Experimental results show that the proposed approach yields the highest accuracy compared to state-of-the-art object tracking methods.
Non-uniform delta modulation for coding of the service channel in optical systems (1993)

A new algorithm for non-uniform delta modulation is presented. It is called statistical delta modulation (SDM) due to the statistical nature of clock instants. SDM is especially suitable for the modulation of the service channel based on the line code redundancy, where no other known delta modulation with uniform clock can be applied. SDM and linear delta modulation (LDM) are compared by computer simulation.
Study on the Standard of Electron Linear Accelerator for Nondestructive Testing (2009)

Through studying the standard of electron linear accelerator for nondestructive testing,some ideas were put forward for referenced.
On the Nature of the Oxidative Heterocoupling of Lithium Enolates (2011)

The coupling of enolates through single-electron oxidation is one of the most direct routes for generating 1,4-dicarbonyls. Recent work on the intermolecular heterocoupling of equimolar amounts of two different enolates through single-electron oxidation has shown that synthetically useful yields beyond those predicted by statistics can be obtained. To determine the underlying basis for the selective formation of heterocoupled products, kinetic, (7)Li NMR, and synthetic studies were performed. The collection of data obtained from these experiments shows that the selective formation of heterocoupled products is a consequence of heteroaggregation of lithium enolates.
Advance Oscilloscope Triggering (2007)

In this paper, we present an advanced triggering method for digital oscilloscopes for measurements involving complex waveforms that are challenging even today. Based on the associative-memory technique and on utilizing a new weighted-hamming-distance parameter, this technique is capable of providing stable oscilloscope triggering, even for complex waveforms where the commonly used voltage level triggering method fails to perform adequately. The proposed technique has been verified by exhaustive software simulations using Matlab and Xilinx foundation series softwares. Furthermore, the technique has been implemented and validated on a XCV300EPQ240 field-programmable gate array device and has given successful initial results using several different kinds of test waveforms
On curvature estimation of ISO surfaces in 3D gray-value images and the computation of shape descriptors (2004)

In this paper, we present a novel method to estimate curvature of iso gray-level surfaces in gray-value images. Our method succeeds where standard isophote curvature estimation methods fail. There is neither a segmentation of the surface needed nor a parametric model assumed. Our estimator works on the orientation field of the surface. This orientation field and a description of local structure is obtained by the Gradient Structure Tensor. The estimated orientation field has discontinuities mod pi. It is mapped via the Knutsson mapping to a continuous representation. The principal curvatures of the surface, a coordinate invariant property, are computed in this mapped representation. From these curvatures, locally the bending energy is computed to describe the surface shape. An extensive evaluation shows that our curvature estimation is robust even in the presence of noise, independent of the scale of the object and furthermore the relative error stays small.
Substrate Recognition by the Collagen-binding Domain ofClostridium histolyticum Class I Collagenase (2001)

Clostridium histolyticum type I collagenase (ColG) has a segmental structure, S1+S2+S3a+S3b. S3a and S3b bound to insoluble collagen, but S2 did not, thus indicating that S3 forms a collagen-binding domain (CBD). Because S3a+S3b showed the most efficient binding to substrate, cooperative binding by both domains was suggested for the enzyme. Monomeric (S3b) and tandem (S3a+S3b) CBDs bound to atelocollagen, which contains only the collagenous region. However, they did not bind to telopeptides immobilized on Sepharose beads. These results suggested that the binding site(s) for the CBD is(are) present in the collagenous region. The CBD bound to immobilized collagenous peptides, (Pro-Hyp-Gly)(n) and (Pro-Pro-Gly)(n), only when n is large enough to allow the peptides to have a triple-helical conformation. They did not bind to various peptides with similar amino acid sequences or to gelatin, which lacks a triple-helical conformation. The CBD did not bind to immobilized Glc-Gal disaccharide, which is attached to the side chains of hydroxylysine residues in the collagenous region. These observations suggested that the CBD specifically recognizes the triple-helical conformation made by three polypeptide chains in the collagenous region.
Online motion planning using incremental construction of medial axis (2004)

This paper deals with the online path planning of mobile robots. We first suggest a systematic method to incrementally construct the Medial Axis of the workspace. This is done by using sensor information for land-marking the nodes of medial axis, which will guide the robot to explore the unknown environment thoroughly. Next, this approach is implemented in an online motion planning algorithm. This method can be generalized to higher spaces, and uses only the line of sight information of sonar sensors. It is much simpler than HGVG method, and is complete. The simulations showed good results for different environments.
EMLA cream for painless skin testing: a preliminary report. (1994)

The purposes of this open study were to evaluate the anesthetic properties of eutectic mixture of local anesthetics (EMLA) prior to intradermal skin testing and to evaluate the possible effect of EMLA on the extent of wheal and flare reaction. Subjects included 40 patients, ranging from 1 to 9 years of age. The eutectic mixture of local anesthetics was applied in a 2-mm thickness to the upper outer arm, covered with a dressing, and allowed to remain in place for one hour. Complete anesthesia was obtained in 36 of the 40 cases (90%), and partial anesthesia occurred in two additional patients. There were no significant differences in wheal or flare reactions between treated and untreated skin. Side effects were minimal. This preliminary report indicates that EMLA cream appears to be a safe and effective means of achieving local anesthesia prior to intradermal skin injection. It does not jeopardize the validity of test results.
The role of the liver and kidneys in the pharmacokinetics of subcutaneously administered teriparatide acetate in rats (2011)

Teriparatide acetate, a synthetic polypeptide fragment consisting of human parathyroid hormone residues 1-34 [hPTH(1-34)], is a bone anabolic agent used to treat osteoporosis. The present study was conducted to characterise the pharmacokinetics of teriparatide acetate in rats after subcutaneous administration. Teriparatide was rapidly absorbed into the circulation and eliminated immediately. No intact teriparatide was detected in the urine. To elucidate the mechanism of teriparatide metabolism, we performed in vivo and in vitro studies using the radiolabelled bioactive analogue, [(125)I]-[Nle(8,18),Tyr(34)]-hPTH(1-34). After subcutaneous administration, the concentration of analogue metabolites increased in the plasma time-dependently. The concentration in the kidneys was more than 3-fold the concentration in the liver. In vitro analyses suggested that kidney radioactivity was associated with degraded bioactive analogue. In model rats, renal failure, but not hepatic failure, affected the pharmacokinetics of teriparatide acetate, which accounted for the decrease in the clearance of teriparatide. In conclusion, our results suggest that after subcutaneous administration of teriparatide acetate, teriparatide is rapidly absorbed and distributed to the liver or kidneys, where it is immediately degraded. The kidneys play a particularly important role in the distribution and metabolism of teriparatide, but not its excretion.
Hypersomnia (2005)

Hypersomnia, a complaint of excessive daytime sleep or sleepiness, affects 4% to 6% of the population, with an impact on the everyday life of the patient Methodological tools to explore sleep and wakefulness (interview, questionnaires, sleep diary, polysomnography Multiple Sleep Latency Test, Maintenance of Wakefulness Test) and psy-chomotor tests (for example, psychomotor vigilance task and Oxford Sleep Resistance or Osier Test) help distinguish between the causes of hypersomnia. In this article, the causes of hypersomnia are detailed following the conventional classification of hypersomnic syndromes: narcolepsy, idiopathic hypersomnia, recurrent hypersomnia, insufficient sleep syndrome, medication- and toxin-dependent sleepiness, hypersomnia associated with psychiatric disorders, hypersomnia associated with neurological disorders, posttraumatic hypersomnia, infection (with a special emphasis on the differences between bacterial and viral diseases compared with parasitic diseases, such as sleeping sickness) and hypersomnia, hypersomnia associated with metabolic or endocrine diseases, breathing-related sleep disorders and sleep apnea syndromes, and periodic limb movements in sleep.
Direct lithiation of hydroxyaromatics (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect lithiation of hydroxyaromaticsGloria Coll, Jeroni Morey, Antoni Costa, and Jose M. SaaCite this: J. Org. Chem. 1988, 53, 22, 5345–5348Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/jo00257a027https://doi.org/10.1021/jo00257a027research-articleACS PublicationsRequest reuse permissionsArticle Views1557Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Weinberger et al (Clin Infect Dis 2014; 58:188-94) (2014)

pneumococcal disease" throughout the text.The publishers regret this error.
New tuberculosis vaccines based on attenuated strains of the <i>Mycobacterium tuberculosis</i> complex (2000)

The world urgently needs a better tuberculosis vaccine. Bacille Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, has been very widely used as a vaccine for many years but has had no major effect on reducing the incidence of tuberculosis. A number of alternative living and non-living vaccines are being investigated. Live vaccine candidates include genetically modified forms of BCG, genetically attenuated strains of the Mycobacterium tuberculosis complex and genetically engineered vaccinia virus and Salmonella strains. Non-living vaccine candidates include killed mycobacterial species, protein subunits and DNA vaccines. One requirement for acceptance of any new vaccine will be a favourable comparison of the protection it induces relative to BCG in a range of animal models, some of which may need further development. Molecular genetic techniques are now available that enable production of live attenuated strains of the M. tuberculosis complex with vaccine potential. In the first of two broadly different approaches that are being used, large numbers of mutants are produced by transposon mutagenesis or illegitimate recombination and are screened for properties that correlate with attenuation. In the second approach, putative genes that may be required for virulence are identified and subsequently inactivated by allelic exchange. In both approaches, mutants that are attenuated need to be identified and subsequently tested for their vaccine efficacy in animal models. Many mutants of the M. tuberculosis complex have now been produced and the vaccine properties of a substantial number will be assessed in the next 3 years.
UV-Assisted Graft Polymerization of <i>N</i>-vinyl-2-pyrrolidinone onto Poly(ether sulfone) Ultrafiltration Membranes:  Comparison of Dip versus Immersion Modification Techniques (2000)

Two different techniques were used to photochemically modify 50 kDa poly(ether sulfone) (PES) membranes with the monomer N-vinyl-2-pyrrolidinone (NVP) to increase surface wettability and decrease adsorptive fouling during the constant volume diafiltration of 0.1 wt % bovine serum albumin (BSA). The filtration performance of the modified membranes was compared to that of a commercially available PES membrane and a regenerated cellulose membrane. Both the dip and immersion modification techniques produced membranes with essentially the same wettability as regenerated cellulose, a wettability increase of 30% over the base PES membrane. There was a substantial decrease in the irreversible adsorptive fouling of the base membrane as measured by the permanent flux drop after water cleaning with respect to the initial buffer flux using either modification (from 0.42 to 0−0.09). The immersion-modified membrane with the best performance exhibited no adsorptive fouling, similar permeability, and higher rejection than the regenerated cellulose membrane. Both modification techniques sharply decreased membrane permeability at high monomer concentrations due to pore blockage by grafted polymer chains. The dip-modified membranes exhibited simultaneous loss of BSA rejection and permeability, which suggested that although radiation cleaved PES bonds and enlarged the pores, the high degree of grafted polymer chains on the surface blocked the pores and decreased the permeability. The immersion- modified membranes retained their rejection because the monomer NVP solution was found to absorb up to 88% of the emitted energy, depending on its concentration, thereby protecting the pore structure from intense irradiation. Thus, the dip and immersion techniques are useful for applications where high protein transmission and retention are desired, respectively.
Tropical Canine Pancytopenia: Clinical, Hematologic, and Serologic Response of Dogs to Ehrlichia canis Infection, Tetracycline Therapy, and Challenge Inoculation (1974)

Journal Article Tropical Canine Pancytopenia: Clinical, Hematologic, and Serologic Response of Dogs to Ehrlichia canis Infection, Tetracycline Therapy, and Challenge Inoculation Get access William C. Buhles, Jr., William C. Buhles, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar David L. Huxsoll, David L. Huxsoll Search for other works by this author on: Oxford Academic PubMed Google Scholar Miodrag Ristic Miodrag Ristic Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 130, Issue 4, October 1974, Pages 357–367, https://doi.org/10.1093/infdis/130.4.357 Published: 01 October 1974 Article history Received: 15 October 1973 Revision received: 24 April 1974 Published: 01 October 1974