gebhart/patrepeval huggingface dataset:
A Sub-2 W 39.8–44.6 Gb/s Transmitter and Receiver Chipset With SFI-5.2 Interface in 40 nm CMOS (2013)

A 39.8-44.6 Gb/s transmitter and receiver chipset designed in 40 nm CMOS is presented. The line-side TX implements a 2-tap FIR filter with delay-based pre-emphasis. The line-side RX uses a quarter-rate CDR architecture. The TX output shows 0.9 ps <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> ISI and 0.2 ps <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rms</sub> RJ at 0.87 W. The RX achieves a jitter tolerance of 0.6 UI <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> at 100 MHz and an input sensitivity of 20 mV pp\mathchar"702D diff at 1.05 W. The combined transmitter/receiver equalization enables 44.6 Gb/s data transmission using 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> -1 PRBS at BER 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> over a channel with >21 dB loss at Nyquist frequency.
Accuracy and precision of the three-dimensional assessment of the facial surface using a 3-D laser scanner (2006)

Three-dimensional (3-D) recording of the surface of the human body or anatomical areas has gained importance in many medical specialties. Thus, it is important to determine scanner precision and accuracy in defined medical applications and to establish standards for the recording procedure. Here we evaluated the precision and accuracy of 3-D assessment of the facial area with the Minolta Vivid 910 3D Laser Scanner. We also investigated the influence of factors related to the recording procedure and the processing of scanner data on final results. These factors include lighting, alignment of scanner and object, the examiner, and the software used to convert measurements into virtual images. To assess scanner accuracy, we compared scanner data to those obtained by manual measurements on a dummy. Less than 7% of all results with the scanner method were outside a range of error of 2 mm when compared to corresponding reference measurements. Accuracy, thus, proved to be good enough to satisfy requirements for numerous clinical applications. Moreover, the experiments completed with the dummy yielded valuable information for optimizing recording parameters for best results. Thus, under defined conditions, precision and accuracy of surface models of the human face recorded with the Minolta Vivid 910 3D Scanner presumably can also be enhanced. Future studies will involve verification of our findings using test persons. The current findings indicate that the Minolta Vivid 910 3D Scanner might be used with benefit in medicine when recording the 3-D surface structures of the face.
The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions (2020)

UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.
Local normal vector field formulation for periodic scattering problems formulated in the spectral domain (2017)

We present two adapted formulations, one tailored to isotropic media and one for general anisotropic media, of the normal vector field framework previously introduced to improve convergence near arbitrarily shaped material interfaces in spectral simulation methods for periodic scattering geometries. The adapted formulations enable the definition and generation of the normal vector fields to be confined to a region of prolongation that includes the material interfaces but is otherwise limited. This allows for a more flexible application of geometrical transformations like rotation and translation per scattering object in the unit cell. Moreover, these geometrical transformations enable a cut-and-connect strategy to compose general geometries from elementary building blocks. The entire framework gives rise to continuously parameterized geometries.
Utility of the Blood for Gene Expression Profiling and Biomarker Discovery in Chronic Fatigue Syndrome (2002)

Chronic fatigue syndrome (CFS) is a debilitating illness lacking consistent anatomic lesions and eluding conventional laboratory diagnosis. Demonstration of the utility of the blood for gene expression profiling and biomarker discovery would have implications into the pathophysiology of CFS. The objective of this study was to determine if gene expression profiles of peripheral blood mononuclear cells (PMBCs) could distinguish between subjects with CFS and healthy controls. Total RNA from PBMCs of five CFS cases and seventeen controls was labeled and hybridized to 1764 genes on filter arrays. Gene intensity values were analyzed by various classification algorithms and nonparametric statistical methods. The classification algorithms grouped the majority of the CFS cases together, and distinguished them from the healthy controls. Eight genes were differentially expressed in both an age-matched case-control analysis and when comparing all CFS cases to all controls. Several of the differentially expressed genes are associated with immunologic functions (e.g., CMRF35 antigen, IL-8, HD protein) and implicate immune dysfunction in the pathophysiology of CFS. These results successfully demonstrate the utility of the blood for gene expression profiling to distinguish subjects with CFS from healthy controls and for identifying genes that could serve as CFS biomarkers.
NEAR-INFRARED SPECTROSCOPY MEASUREMENT OF REGIONAL TISSUE OXYHEMOGLOBIN SATURATION DURING HEMORRHAGIC SHOCK (1999)

Adequate resuscitation of patients from shock states depends on restoration of oxygen delivery (DO2) to tissues. Direct measurement of systemic DO2 during shock states requires invasive techniques such as pulmonary artery catheterization. These experiments were performed to examine the ability of near-infrared spectroscopy (NIRS), to measure regional tissue oxygenation in a large-animal model of hemorrhagic shock, and to compare these measures to global measures of oxygen delivery. Splenectomized female pigs (n = 11) were anesthetized, instrumented, and monitored. NIRS probes were placed on the leg, in the stomach via nasogastric tube, and on the liver during laparotomy. Hemorrhagic shock was induced by phlebotomy of 28% of blood volume. After 1 hour, resuscitation was with shed blood and crystalloid until cardiac output plateaued. Measurements of physiologic parameters, blood gases, lactate, intramucosal pH, and NIRS values for regional tissue hemoglobin oxygen saturation (StO2), and cytochrome a,a3 redox state were recorded at intervals throughout the experiment. Tissue oxygenation as measured by oxyhemoglobin saturation and cytochrome a,a3 redox (NIRS) correlated with measures of systemic DO2 throughout the experiment. The liver probe demonstrated blunted changes in tissue oxygenation suggesting relatively protected circulation. Intramucosal pH did not correlate well with DO2. Regional tissue oxygenation as measured by NIRS shows excellent correlation with global oxygen delivery. NIRS may allow estimation of systemic oxygen delivery using rapid non-invasive techniques.
Enhanced Smooth Muscle Cell Coverage of Microvessels Exposed to Increased Hemodynamic Stresses In Vivo (2003)

During vascular remodeling in adult organisms, new capillary growth is often coupled with the adaptation of arterioles and venules, a process that requires the recruitment and differentiation of precursor cells into smooth muscle. We studied the in vivo adaptation of microvessels in the presence of elevated pressure and circumferential wall stress using a ligation strategy for mesenteric microvascular networks. Acute pressure increases of 42.6+/-18% and 17.1+/-2.3% were respectively elicited in the 25- to 30-microm-diameter venules and arterioles supplying the networks. Wall shear rates were not significantly changed; however, diameters were increased in >10-microm-diameter venules and >20-microm-diameter arterioles. Smooth muscle cell contractile phenotype was determined in all microvessels by observing the expression of smooth muscle myosin heavy chain (SM-MHC; a marker of fully differentiated smooth muscle) and smooth muscle alpha-actin (a marker for all smooth muscle, including immature smooth muscle of fibroblast/pericyte lineage). The ratio of SM-MHC positive vessel length to smooth muscle alpha-actin-positive vessel length increased >2-fold after 5 and 10 days of the ligation treatment. Smooth muscle proliferation was studied by bromodeoxyuridine incorporation, and the increase in SM-MHC-labeled microvessel length density was accompanied by no measurable change in proliferation of SM-MHC-labeled cells 5 and 10 days after ligation. These results indicate that after a period of 5 or 10 days, mesenteric microvessels <40 microm in diameter exposed to elevated pressure and wall strain exhibit an enhanced coverage of mature, fully differentiated smooth muscle cells.
Development of a New Tablet Formulation of Theophylline: In Vitro and in Vivo Studies (1983)

AbstractThe preparation of a new scored 250 mg theophylline tablet is described, for which effects of particle size of the active principle, aspects of granulation and changes in tabletting settings were investigated.In vitro studies showed the dissolution rate from tablets prepared from theophylline of commercial quality (50 μm) or of selected particle size (30 μm) to be faster than that from tablets prepared from micronized theophylline (10 μm). In vivo studies in dog showed that only the tablet from theophylline of selected particle size has the same bioavailability as an aqueous solution.The scale up study showed that the characteristics of the tablets, including dissolution rate, are independent of the formulation factors.
Ultrathin broadband nearly perfect absorber with symmetrical coherent illumination (2012)

As highlighted by recent articles [Phys. Rev. Lett. 105, 053901 (2010) and Science 331, 889-892 (2011)], the coherent control of narrowband perfect absorption in intrinsic silicon slab has attracted much attention. In this paper, we demonstrate that broadband coherent perfect absorber (CPA) can be achieved by heavily doping an ultrathin silicon film. Two distinct perfect absorption regimes are derived with extremely broad and moderately narrow bandwidth under symmetrical coherent illumination. The large enhancement of bandwidth may open up new avenues for broadband applications. Subsequently, interferometric method is used to control the absorption coherently with extremely large contrast between the maximum and minimum absorptance. Compared with the results in literatures, the thin film CPAs proposed here show much more flexibility in both operation frequency and bandwidth.
Generalized Serial Search Code Acquisition: The Equivalent Circular State-Diagram Approach (1983)

A simple circular state-diagram method has been recently proposed [2] for the modeling, analysis and optimization of straight serial search code acquisition in spread spectrum systems. Herein, the approach is generalized to arbitrary serial strategies, such as the Z-search, expanding window search etc. The basic idea is the construction of equivalent circular state-diagrams, wherefrom the transform-domain description of the stochastic acquisition process is derived. The method circumvents any complicated time-domain combinatorial arguments, is readily systematized and includes recent results as special cases.
Der Einfluß verschiedener organischer Lösungsmittel auf das Wachstum von Bakterien (1971)

Abstract Es wurden 10 organische Lösungsmittel auf ihre antibakterielle Wirkung untersucht, um ihre Brauchbarkeit als Lösungsvermittler für Resistenzbestimmungen von Bakterien gegenüber in Wasser schwer löslichen Chemotherapeutica zu ermitteln. Aceton, Acetonitril und Diäthylformamid eignen sich nicht. Diacetonalkohol wird von S. aureus bis 2% und 1,4‐Dioxan von Kl. pneumoniae bis 1% toleriert. Die höchsten Toleranzgrenzen erreicht das Diäthylenglykolmonoäthylätheracetat, das bei S. aureus, E. coli, Kl. pneumoniae und Ps. aeruginosa bis 2% keine Wachstumshemmung verursacht. Die Grenzkonzentrationen für Formamid, Dimethylformamid und 1,4‐Dioxan variieren bei den getesteten Keimen von maximal 2% bis unter 1%.
Global microRNA level regulation of EGFR‐driven cell‐cycle protein network in breast cancer (2012)

The EGFR-driven cell-cycle pathway has been extensively studied due to its pivotal role in breast cancer proliferation and pathogenesis. Although several studies reported regulation of individual pathway components by microRNAs (miRNAs), little is known about how miRNAs coordinate the EGFR protein network on a global miRNA (miRNome) level. Here, we combined a large-scale miRNA screening approach with a high-throughput proteomic readout and network-based data analysis to identify which miRNAs are involved, and to uncover potential regulatory patterns. Our results indicated that the regulation of proteins by miRNAs is dominated by the nucleotide matching mechanism between seed sequences of the miRNAs and 3'-UTR of target genes. Furthermore, the novel network-analysis methodology we developed implied the existence of consistent intrinsic regulatory patterns where miRNAs simultaneously co-regulate several proteins acting in the same functional module. Finally, our approach led us to identify and validate three miRNAs (miR-124, miR-147 and miR-193a-3p) as novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer.
EW 101: a first course in electronic warfare (2000)

This popular series of tutorials, featured over a period of years in the Journal of Electronic Defense, is now available in a single volume. Organized into chapters with new introductory and supplementary material from the author, you get clear, concise and well-illustrated examinations of critical topics such as antenna parameters, receiver sensitivity, processing tasks, and search strategies, LPI signals, jamming, communication links, and simulation. The chapters define key terms and explain how and why particular technologies are relevant to electronic defense. Detailed charts, diagrams and
Lesion response of long‐term and recently immigrated resident endoneurial macrophages in peripheral nerve explant cultures from bone marrow chimeric mice (2002)

Resident macrophages of the peripheral nervous system have recently been shown to respond rapidly to Wallerian degeneration before the influx of blood-derived macrophages. Because resident endoneurial macrophages are slowly but incompletely exchanged from the blood within 3 months, they could potentially comprise a heterogenous cell population consisting of long-term resident cells and more mobile cells undergoing turnover. We used bone marrow chimeric mice created by transplanting bone marrow from green fluorescent protein-transgenic mice into irradiated wildtype recipients to selectively analyse the response of these two resident macrophage populations to Wallerian degeneration in sciatic nerve explant cultures. In such nerves, recently immigrated macrophages exhibit green fluorescence whereas long-term resident macrophages do not. Studies in cultures from wildtype controls revealed rapid morphological changes of resident macrophages towards a bloated phenotype, a proliferative response resulting in a 3.7-fold increase of macrophage numbers over 2 weeks, and phagocytosis of myelin basic protein-immunoreactive myelin debris. When chimeric mice were analysed, both populations of resident endoneurial macrophages participated in morphological transformation, proliferation and phagocytosis. Quantitative studies revealed a stronger proliferative and phagocytic response in long-term resident endoneurial macrophages compared with recently immigrated macrophages. Our results point towards subtle, but not principal, differences between the two macrophage populations, which might indicate different stages of macrophage differentiation rather than the existence of entirely distinct endoneurial macrophage populations. The results further underline the versatility of resident endoneurial macrophages following peripheral nerve injury, which is reminiscent of the lesion response of microglial cells within the brain.
Novel Compounds in the Therapy of Breast Cancer: Opportunities for Integration with Docetaxel (2001)

Increasingly, novel agents are being developed specifically at inhibition of growth factor receptors and events within the signal transduction pathway. These agents include the epidermal growth factor tyrosine kinase inhibitors, the farnesyl transferase inhibitors, and bcl-2 antisense oligonucleotides. Along with these new approaches to molecular targeting, it will be necessary to develop new study designs for drug evaluation. Target validation in both normal surrogate tissues and tumor tissue becomes increasingly relevant in early clinical trials. Furthermore, antitumor efficacy may no longer correlate with normal hematological or nonhematological toxicity, and it may be more appropriate in phase I trials to identify the maximum target inhibition dose rather than the maximum tolerated dose. Moreover, measures of cytoreduction, such as complete and partial response, may be less relevant than disease stabilization for some of these novel agents which have limited cytotoxic effects and would be considered cytostatic agents. Assessment of single-agent activity and the future role in conjunction with cytostatic agents represents the single most important challenge facing the clinical development of these molecular targeted therapies.
Objective Evaluation of Skin Pressure Distribution of Graduated Elastic Compression Stockings (2005)

Background The beneficial effects of graduated elastic compression stockings (GCSs) have been demonstrated. However, their pressure performances are variable and unstable in practical applications owing to many influencing factors. Comprehensive assessment of skin pressure profiles may help elucidate the mechanisms of action of compression stockings. Objective The objective of this study was to quantify and objectively evaluate the magnitude and distribution of skin pressure applied by different GCSs and to analyze the possible reasons influencing the stocking pressure performances. Methods Six healthy females were required to wear eight kinds of GCSs with different pressure levels while standing upright. The skin pressures of 16 different positions located in four heights and four directions of the lower limb were measured and recorded by FlexiForce interface pressure sensors (Tekscan, Inc., Boston, MA, USA) and a multichannel measuring system. Results The pressure gradients, pressure levels, and testing locations significantly influenced skin pressure (p < .001). All tested GCSs exerted the highest pressure at the ankle region, and the pressure gradually decreased toward the thigh, which follows the gradient design of GCSs. However, many of them failed to produce the perfect pressure gradients from the ankle region to the calf region. Obviously, reversed pressure gradients occurred in the medial side of the leg, where the pressure at the ankle region was lower than that on the prominent part of the calf by 36% on average. GCSs with higher pressure levels applied higher skin pressure on the lower limb. The pressure at the anterior side was far higher than that in the medial and lateral directions. The distribution patterns of skin pressure at transverse sections were similar to the anatomic outlines of cross sections of the leg. The measured average ankle pressure of all tested GCSs did not reach the pressures specified by the manufacturers. Conclusion Skin pressure distributions and magnitudes applied by GCSs were significantly influenced by the locations of testing points in terms of height and direction, which are determined by the specific anatomic structure and body shape of individual human legs and potentially influenced by the pressure sensor and testing methods.
Learning to Block Undesired Comments in the Blogosphere (2013)

A significant amount of the available information on web sites come from the interaction with users, such as news sites and blogs, where readers can post comments and sometimes develop habits of frequenting them. Some blogs specialize in certain subjects, receive the users credibility and become references in the field. However, the ease of inserting content through text comments makes room for unwanted messages, which affect the user experience, reduce the quality of the information provided by the websites and indirectly causing personal and economic losses. Given this scenario, this paper presents a comprehensive analysis of machine learning techniques applied to automatically detect undesired comments posted on blogs. Experiments carried out with a real and public database indicate that support vector machines and logistic regression, trained with both attributes extracted from the text messages and metadata from the posts, are promising in the task of filtering unwanted comments.
Fibrinogen deposition and macrophage-associated fibrin formation in malignant and nonmalignant lymphoid tissue. (1992)

Nonmalignant lymphoid tissue and tissue from patients with nodular sclerosis, Hodgkin's disease, and large cell lymphocytic lymphoma was examined by immunohistochemical techniques for the occurrence in situ of components of coagulation and fibrinolysis reaction pathways. Staining for material interpreted as fibrinogen was observed in abundance in both malignant and reactive lymphoid tissue. Fibrin also occurred to a variable extent but focally in all tissues. Components of coagulation pathways, including tissue factor, factor VII, factor X, and factor XIII ("a" subunit), were restricted to tissue macrophages. Double-labeling techniques revealed fibrin in direct apposition to tissue macrophages. We conclude that fibrinogen and fibrin occur in both benign and malignant lymphoid tissue and that the transformation of fibrinogen to fibrin is attributable to macrophage-initiated thrombin formation. We postulate that both systemic and local hypercoagulability associated with these disorders may be attributable to macrophage activation resulting in expression of procoagulant activity.
A force control assisted robot path generation system (2008)

This paper presents a force control assisted path generation system that can significantly reduce the time, effort and expertise requirements for programming complex paths in a typical industrial environment. The basic idea is to let the user first teach a few approximate positions along the desired path using a force control lead through method, and then the robot executes a force feedback contour following task with the guidance of the approximate points. The actual tool path is recorded during the contour tracking process. Post processing algorithms are applied to make additional adjustments to the recorded path if needed. Tests using real life applications have demonstrated the robustness and effectiveness of the presented system in industrial settings.