gebhart/patrepeval huggingface dataset:
Synthesis and reactions of cyclic amidines (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and reactions of cyclic amidinesEmil J. Moriconi and Albert A. CevascoCite this: J. Org. Chem. 1968, 33, 5, 2109–2111Publication Date (Print):May 1, 1968Publication History Published online1 May 2002Published inissue 1 May 1968https://pubs.acs.org/doi/10.1021/jo01269a091https://doi.org/10.1021/jo01269a091research-articleACS PublicationsRequest reuse permissionsArticle Views684Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Secretory phospholipase A<sub>2</sub> induces delayed neuronal COX‐2 expression compared with glutamate (2002)

Agonists of the binding site for secretory phospholipase A(2) (sPLA(2)) potentiate glutamate-induced neuronal cell death in primary cell cultures and in vivo (Kolko et al. [1996] J. Biol. Chem. 271:32722; Kolko et al. [1999] Neurosci. Lett. 274:167]. Here, we tested the hypothesis that COX-2 expression participates in the brain response to sPLA(2). sPLA(2)-OS(2), a selective ligand of a neuronal sPLA(2)-binding site, was injected into the rat striatum, and early-response gene expression was monitored by in situ hybridization using (35)S-radiolabeled oligonucleotide probes and immunohistochemistry. An up-regulation of COX-2, c-fos, and c-jun, but not COX-1, was observed around the lesion as well as in the neocortex 4 hr after the injection. Hippocampal up-regulation of COX-2 was seen in dentate gyrus 8 hr after injection. When glutamate was injected, up-regulation of the early-response genes peaked after 2 hr. Our studies showed 1) that sPLA(2) selectively induced neuronal COX-2; 2) that this induction was delayed (4 hr after injection of sPLA(2)) compared with that elicited by glutamate (2 hr after injection), suggesting different signaling; and 3) that c-fos and c-jun were induced around the infarct area as soon as 2 hr after injection, but in other aspects followed a time course similar to that of COX-2. We conclude that sPLA(2) may modulate neuronal COX-2 expression through mechanisms that differ from those of glutamate-induced COX-2 expression.
Piles of objects (2010)

We present a method for directly modeling piles of objects in multi-body simulations. Piles of objects represent some of the more interesting, but also most time-consuming portion of simulation. We propose a method for reducing computation in many of these situations by explicitly modeling the piles that the objects may form into. By modeling pile behavior rather than the behavior of all individual objects, we can achieve realistic results in less time, and without directly modeling the frictional component that leads to desired pile shapes. Our method is simple to implement and can be easily integrated with existing rigid body simulations. We observe notable speedups in several rigid body examples, and generate a wider variety of piled structures than possible with strict impulse-based simulation.
Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers. (1996)

The blood-contacting properties of polyethylene coated with a lubricious hydrophilic coating; an uncoated polyethylene; or a photoheparin-treated polyethylene-negative control sample were compared by measuring fibrinogen adsorption, antifibrinogen binding, and platelet attachment from human plasma. The polyethylene surfaces coated with a hydrophilic polymer were found to be similar to surfaces coated with heparin. Fibrinogen adsorption on the hydrophilic coating was 60% lower than adsorption on either the uncoated or heparin-coated polyethylene samples. Antifibrinogen binding from buffer to the hydrophilic coating was also reduced more than 85% from binding to uncoated polyethylene samples. Both the hydrophilic coating and heparin coating showed a reduction in platelet attachment by a factor of 100 over the uncoated sample as well as significantly reduced platelet activation.
Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease (2004)

The change in threshold did not seem to correlate with dysfunction of inhibitory intracortical cholinergic and GABAergic circuits, nor with the central cholinergic activity. We propose that the hyperexcitability of the motor cortex is caused by an abnormality of intracortical excitatory circuits.
The natural combination of full and image-based waveform inversion (2015)

Integrating migration velocity analysis and full waveform inversion can help reduce the high non-linearity of the classic full waveform inversion objective function. The combination of inverting for the long and short wavelength components of the velocity model using a dual objective function that is sensitive to both components is still very expensive and have produced mixed results. We develop an approach that includes both components integrated to complement each other. We specifically utilize the image to generate reflections in our synthetic data only when the velocity model is not capable of producing such reflections. As a result, we get the migration velocity analysis working when we need it, and we mitigate its influence when the velocity model produces accurate reflections (possibly first for the low frequencies). This is achieved using a novel objective function that includes both objectives. Applications to a layered model and the Marmousi model demonstrate the main features of the approach.
Multivariate approach to quality control in clinical chemistry. (1998)

When monitoring analyzer performance in the clinical setting, laboratories are required to test multiple concentrations of control material on a daily basis. Because of the nature of laboratory testing, there is the potential for correlation between the concentrations of control material being monitored. Although traditional clinical quality-control approaches make an underlying assumption of independence with respect to the control concentrations, this will not always be the case. The presence of correlation in some circumstances suggests the use of a new approach for evaluating clinical laboratory monitoring data: the multivariate control chart. Such a chart (the chi2 chart) is evaluated and compared with traditional quality-control approaches used in the laboratory setting. Results indicate that the multivariate approach provides an attractive alternative to many traditional methods of quality assurance when control concentrations are correlated.
Adversarial vulnerability for any classifier (2018)

Despite achieving impressive performance, state-of-the-art classifiers remain\nhighly vulnerable to small, imperceptible, adversarial perturbations. This\nvulnerability has proven empirically to be very intricate to address. In this\npaper, we study the phenomenon of adversarial perturbations under the\nassumption that the data is generated with a smooth generative model. We derive\nfundamental upper bounds on the robustness to perturbations of any\nclassification function, and prove the existence of adversarial perturbations\nthat transfer well across different classifiers with small risk. Our analysis\nof the robustness also provides insights onto key properties of generative\nmodels, such as their smoothness and dimensionality of latent space. We\nconclude with numerical experimental results showing that our bounds provide\ninformative baselines to the maximal achievable robustness on several datasets.\n
Influence of Insemination on the Implantation of Transferred Rat Blastocysts (1984)

Embryo transfer probably produces a lower incidence of implantation than the physiological incidence despite all other factors seeming similar. The only factor known to be present physiologically and absent in embryo transfer is the presence of sperm in the uterine cavity. Implantation and decidualization are often considered a modified form of inflammatory reaction. Semen contains factors which excite an inflammatory response. This project attempted to determine whether insemination would affect the implantation rate of transferred blastocysts in the rat. The figures showed a significantly increased implantation rate after insemination at day 4 of pseudopregnancy as compared to controls.
Improved adenoma detection with Endocuff Vision: the ADENOMA randomised controlled trial (2018)

NCT02552017, Results; ISRCTN11821044, Results.
<title>Integrated portable system for suspect identification and tracking</title> (1997)

Recent advances in information technology offer excellent potential for law enforcement personnel to enhance their surveillance and assessment capabilities. These personnel, regardless of their location, will be able to rapidly access critical information both from the scene of an incident and from archived records in a central database. Gathering information quickly from remote locations enables decision makers to accurately assess the seriousness of an incident, and in turn, provide the responders at the scene with the supporting information they need to do their jobs safely and effectively.
AnaConDa?? Reflection Filter: Bench and Patient Evaluation of Safety and Volatile Anesthetic Conservation (2006)

This study shows that the device is generally reliable, but that there are several conditions under which it might deliver more anesthetic than intended.
A Full On-Chip CMOS Clock-and-Data Recovery IC for OC-192 Applications (2008)

In this paper, a fully integrated OC-192 clock-and-data recovery (CDR) architecture in standard 0.18-mum CMOS is described. The proposed architecture integrates the typically large off-chip filter capacitor by using two feed-forward paths configuration to generate zero and pole and satisfies SONET jitter requirements with a total power dissipation (including the buffers) of 290 mW. The measured RMS jitter of the recovered data is 0.74 ps with a bit-error rate less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> when the input pseudorandom bit sequence (PRBS) data pattern has a pattern length of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> - 1 and a total horizontal eye closure of 0.54 peak-to-peak unit interval (Ul <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> ) due to the added intersymbol interference distortion by passing data through 9-in FR4 printed circuit board trace. The chip exceeds SONET OC-192 jitter tolerance mask, and high-frequency jitter tolerance is over 0.31 Ul <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> by applying PRBS data with a pattern length of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> - 1.
Locking of hormone in the beta-adrenergic receptor by attack on a sulfhydryl in an associated component. (1982)

Isoproterenol incubated with turkey erythrocyte membranes causes exposure of a specific --SH in a component associated with the beta-adrenergic receptor, presumably in the guanyl nucleotide binding protein. Addition of a reagent which interacts with that specific --SH results in trapping of the hormone in the receptor. As a consequence, the number of hormone binding sites and the function of the receptor are both drastically reduced. Extended incubation at alkaline pH or addition of GDP or GTP at high concentration reactivate the beta-adrenergic receptor. Labeled antagonist binding as well as function of the receptor in activating an adenylate cyclase system are restored. The findings suggest that the normal interaction of the hormone-receptor complex with the guanyl nucleotide binding protein involves a conformational change which transiently locks the hormone in the receptor. GTP releases the tight interaction while addition of an --SH reagent traps the ternary complex of hormone-receptor-guanyl nucleotide binding protein in the locked conformation. Since the components of different hormone-activated adenylate cyclase systems were shown to be interchangeable, it seems likely that the hormone-receptor interaction with the guanyl nucleotide binding protein, as revealed in the present study, is not limited to beta-adrenergic receptor systems.
Electrochemical treatment of wastewater containing organic pollutants (1990)

A simple method is presented which allows to est. the facility of the electrochem. oxidn. of org. species using the electrochem. oxidizability index (EOI) and the degree of oxidn. using the electrochem. oxygen demand (EOD). At platinum anode only benzene derivs. of which one of the substituents is electron donating are effectively oxidized giving maleic acid as the principle final product. EOI values for oxidn. of phenol are independent of c.d. and temp. but increase with phenol concn. and pH. EOI values are strongly dependent on the type of anode material used; Ti/SnO2 anodes give the highest EOI values. At Ti/IrO2 anode, the EOI values strongly increase in the presence of NaCl and decrease in the presence of NaBr in the electrolyte. A decrease of toxicity is obsd. during the electrochem. treatment of phenol. [on SciFinder (R)]
Potato growing in Iowa (1950)

Iowa does not grow enough potatoes to supply its own needs. The average yield is about 100 bushels per acre. Because of high summer temperatures and uneven distribution of rainfall during the growing season, the climate is not ideal for the production of potatoes. However, yields in farm and home gardens could easily be doubled by following the practices outlined here. Several large commercial growers in Iowa average 400 to 500 bushels per acre of marketable potatoes each year.\nAn ideal potato soil should be high in fertility, friable, deep, high in organic matter, and should have an acid to slightly acid reaction. Soil type definitely influences the shape of the tuber. Light, well-aerated soils produce better shaped tubers than heavy soils. Sandy soils are excellent for early potatoes, but in dry seasons the crop may suffer from lack of moisture. Heavy clays fail to produce tubers of good quality or shape. Sandy loams and medium loams are the most satisfactory upland soils. Much of the commercial acreage in Iowa is on peat and muck. They are excellent potato soils when they have adequate drainage. Because of their high percentage of organic matter and lower temperature, they yield more heavily than mineral or upland soils, when properly managed.
Species Specificity of Monoclonal Antibodies to Human Tartrate-Resistant Acid Phosphatase (1998)

Tartrate-resistant acid phosphatase (TRAP) is expressed abundantly by osteoclasts and is required for bone resorption. This enzyme is emerging as an important biomarker in bone pathology, both for histochemical identification of osteoclasts and as a serum marker of osteoclast activity and increased bone turnover. Rat and mouse models are becoming popular systems for studying osteoclast development, bone physiology and morphogenesis, and bone diseases such as osteoporosis. We have developed two unique antibodies to human TRAP purified from hairy cell leukemia spleen. Both antibodies (9C5 and 14G6) are suitable for immunohistochemistry of osteoclasts and macrophages. Only one (14G6) is capable of immunoprecipitating active TRAP from human cell lysates. Antibody 9C5 reacts with a denatured epitope of TRAP while antibody 14G6 probably reacts with a native, conformational determinant. The high degree of homology among TRAPs of various species predicts that these antibodies should be suitable for work in experimental animals as well as humans. Immunohistochemical staining, electrophoretic analyses, immunoprecipitation and immunoblotting assays of human rat and mouse TRAP were carried out to test the validity of these antibodies as cell markers in rodents. Both antibodies were suitable for immunohistochemistry in all species. Antibody 9C5 was suitable for immunoblotting of denatured TRAP of all species tested. Antibody 14G6 reacted with the native TRAP of humans only and failed to immunoprecipitate mouse or rat TRAP activity. Although TRAP is a phylogenetically conserved protein, subtle, species-specific determinants exist. Care should be exercised when anti-TRAP antibodies are used for immunoassay in experimental animals.
Electron transfer between metallointercalators bound to DNA: Spectral identification of the transient intermediate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron transfer between metallointercalators bound to DNA: Spectral identification of the transient intermediateEric D. A. Stemp, Michelle R. Arkin, and Jacqueline K. BartonCite this: J. Am. Chem. Soc. 1995, 117, 8, 2375–2376Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ja00113a037https://doi.org/10.1021/ja00113a037research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Printing Tablets with Fully Customizable Release Profiles for Personalized Medicine (2015)

Personalizing the release profiles of drugs is important for different people with different medical and biological conditions. A technically simple and low-cost method to fabricate fully customizable tablets that can deliver drugs with any type of release profile is described. The customization is intuitively straightforward: the desired profile can simply be "drawn" and printed by a 3D printer.
A Unified pH Scale for All Phases (2010)

One for all! On the basis of the absolute chemical potential of the proton, a unified absolute pH scale is introduced that is universally applicable in the gas phase, in solution, and in the solid state. With this scale, it is possible to directly compare acidities in different media, and to give a thermodynamically meaningful definition of superacidity. This scale can be used in all areas with variable proton activity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
CERAMENT treatment of fracture defects (CERTiFy): protocol for a prospective, multicenter, randomized study investigating the use of CERAMENT™ BONE VOID FILLER in tibial plateau fractures (2014)

ClinicalTrials.gov: NCT01828905.
Comparative Analysis of Shift Variance and Cyclostationarity in Multirate Filter Banks (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Multirate filter banks introduce periodic time-varying phenomena into their subband signals. The nature of these effects depends on whether the signals are regarded as deterministic or as random signals. We analyze the behavior of deterministic and wide-sense stationary (WSS) random signals in multirate filter banks in a comparative manner. While aliasing in the decimation stage causes subband energy spectra of deterministic signals to become shift-variant, imaging in the interpolation stage causes WSS random signals to become WS cyclostationary (WSCS). We provide criteria to quantify both shift variance and cyclic nonstationarity. For shift variance, these criteria separately assess the shift dependence of energy and of energy spectra. Similarly for nonstationarity, they separately assess the nonstationary behavior of signal power and of power spectra. We show that, under aliasing cancellation and perfect reconstruction constraints of paraunitary and biorthogonal filter banks, these criteria evaluate the behavior of deterministic and WSS random signals in a consistent, dual way. We apply our criteria to paraunitary and biorthogonal filter banks as well as to orthogonal block transforms, and show that, for critical signals such as lines or edges in image data, the biorthogonal <formula formulatype="inline"><tex>$9/7$</tex></formula> filters perform best among these. </para>