gebhart/patrepeval huggingface dataset:
Genetic Aspects of Alzheimer Disease (2009)

New research in the genetics of AD have implicated novel genes as having a role in the disease, but these findings have not been replicated nor have specific disease causing mutations been identified. To date, clinical genetic testing is limited to familial early-onset disease for symptomatic individuals and asymptomatic relatives and, although not recommended, amyloid precursor protein apolipoprotein E testing as an adjunct to diagnosis of symptomatic individuals.
Classification spanning private databases (2006)

In this paper, we study the classification problem involving information spanning multiple private databases. The privacy challenges lie in the facts that data cannot be collected in one place and the classifier itself may disclose private information. We present a novel solution that builds the same decision tree classifier as if data are collected in a central place, but preserves the privacy of participating sites.
Metabolic requirements for cancer cell proliferation (2016)

Our analysis clarifies the differential needs for central carbon metabolism precursors, glutamine-derived nitrogen, and cofactors such as ATP, NADPH, and NAD(+), while also providing justification for various extracellular nutrient uptake behaviors observed in tumors. Collectively, these results demonstrate how stoichiometric considerations alone can successfully predict empirically observed phenotypes and provide insight into biochemical dynamics that underlie responses to metabolic perturbations.
On the performance of Time Varying Step-size Least Mean Squares(TVS-LMS) adaptive filter for MA reduction from PPG signals (2011)

Clinical Investigation of hypoxic status of the patients requires accurate information about the heart rate and oxygen saturation of arterial blood. Pulse oximeters are widely used for monitoring these parameters by recording the raw pulse oximeter signal, namely Photoplethysmogram (PPG). The recorded PPG Signal acquired using PPG sensors are usually corrupted with Motion Artifacts (MA) due to the voluntary or involuntary movements of patient. Reduction of MA has received much attention in the literature over recent years. In this paper, we present an efficient adaptive filtering technique based on Time Varying Step-size Least Mean Squares (TVS-LMS) algorithm for MA reduction. The novelty of the method lies in the fact that a synthetic noise reference signal for adaptive filtering, representing MA noise, is generated internally from the MA corrupted PPG signal itself instead of using any additional hardware such as accelerometer or source-detector pair for noise reference signal generation. Convergence analysis, SNR calculations and Statistical analysis revealed that the proposed TVS-LMS method has a clear edge over the Constant Step-size LMS (CS-LMS) based adaptive filtering technique. Test results, on the PPG data recorded with different MAs, demonstrated the efficacy of the proposed TVS-LMS algorithm in MA reduction and thus making it best suitable for real-time pulse oximetry applications.
Transport and related properties of (Ga, Al)As/GaAs double heterostructure bipolar junction transistors (1987)

This paper presents a study of the transport and related properties of GaAs double heterostructure bipolar junction transistors with GaAlAs emitters and collectors utilizing both graded and abrupt junctions. By studying the temperature dependence of current-voltage characteristics, the recombination mechanisms in the transition regions associated with the base-emitter, the base-collector junction, and the quasi-neutral base region have been quantitatively separated. The junction corresponding to growth of GaAs on GaAlAs is found to have higher nonradiative recombination. For abrupt junctions, it also shows a lower barrier for electron injection than does the GaAlAs/GaAs junction. At mid-10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> base doping, the junctions show ideal emission/ diffusion transport at high currents, recombination-dominated transport in a medium current range, and transport with a characteristic energy greater than twice the thermal energy at very low currents. Due to excess recombination current in the devices, the offset voltage is shown to be sensitive to the ratio of emitter and collector junction areas. At low temperatures, transport across the injecting interface of abrupt devices is dominated by tunneling and in the quasi-neutral base by diffusion. The devices exhibit gain at temperatures as low as 4.2 K. The current gain below 77 K appears to be limited by radiative recombination lifetime, and at higher temperatures by nonradiative recombination and injection efficiency. Transistors with current gains of 300 to 500 have been achieved at small emitter dimensions of 1.6 µm × 4.0 µm and at current densities exceeding 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> A . cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . At current densities of 100 A . cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , some of the transistors exhibited gains approaching 100. These devices had an offset voltage of less than 100 mV. Self-aligned devices have also been fabricated and show current gains of 20 to 50 at similar dimensions. In the inverted configuration, gains of up to 50 were observed for non-self-aligned transistors. The dependence of device Characteristics upon the structure indicates that surface effects are minimal. The negative resistance exhibited by these devices at high currents is shown to be due to temperature effects resuiting from the 10-µs or lower thermal time constants.
21.3: <i>Invited Paper:</i> Latest Development of “System‐on‐Glass” Display with Low Temperature Poly‐Si TFT (2004)

Abstract A 2.3‐inch diagonal, QVGA formatted “System‐on‐glass” display has been developed by low temperature poly‐Si TFT LCD technology. This display fully integrates 6‐bit RGB digital interface drivers as well as all the power‐supply circuitry to drive the LCD, which requires neither external ICs nor power supply ICs. This paper discusses the newly developed TFT circuit technologies used in this LCD. The development trend in the “System‐on‐glass” display is also reviewed.
Use and Maintenance of Projector (2008)

Along with the development of technology,the projector is widely used in classroom teaching and enterprise management. As a valuable equipment,the administrator should be fully aware of its maintenance and operate proficiently. This article introduces the maintenance and the overhauling methods of the educational projectors.
A multilevel-voltage source rectifier with a three-phase diode bridge circuit as a main power circuit (2003)

A novel system obtaining very low distorted waveforms of input AC currents of three-phase rectifier circuits is proposed. This rectifier system consists of a three-phase diode bridge circuit as a main power circuit, AC reactors, and an additional circuit which serves as an active filter with low switching frequencies and a forced commutation circuit for the diodes. The authors describe the operation principle, analysis of the waveforms of input voltage and current, multiple phase-shifted systems, and experimental results. The proposed system gives excellent input current waveforms and has many advantages over conventional systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neoadjuvant Docetaxel and Capecitabine and the Use of Thymidine Phosphorylase as a Predictive Biomarker in Breast Cancer (2007)

DC chemotherapy exhibited a similar pCR rate compared with standard taxane regimens, with increased toxicity. TP expression was not up-regulated after docetaxel and did not correlate with therapeutic response. Core breast biopsy after neoadjuvant chemotherapy accurately predicted pathologic response.
Spinal Loading Patterns From Biomechanical Modeling Explain the High Incidence of Vertebral Fractures in the Thoracolumbar Region (2017)

Vertebral fractures occur most frequently in the mid-thoracic and thoracolumbar regions of the spine, yet the reasons for this site-specific occurrence are not known. Our working hypothesis is that the locations of vertebral fracture may be explained by the pattern of spine loading, such that during daily activities the mid-thoracic and thoracolumbar regions experience preferentially higher mechanical loading compared to other spine regions. To test this hypothesis, we used a female musculoskeletal model of the full thoracolumbar spine and rib cage to estimate the variation in vertebral compressive loads and associated factor-of-risk (load-to-strength ratio) throughout the spine for 119 activities of daily living, while also parametrically varying spine curvature (high, average, low, and zero thoracic kyphosis models). We found that nearly all activities produced loading peaks in the thoracolumbar and lower lumbar regions of the spine, but that the highest factor-of-risk values generally occurred in the thoracolumbar region of the spine because these vertebrae had lower compressive strength than vertebrae in the lumbar spine. The peaks in compressive loading and factor-of-risk in the thoracolumbar region were accentuated by increasing thoracic kyphosis. Activation of the multifidus muscle fascicles selectively in the thoracolumbar region appeared to be the main contributor to the relatively high vertebral compressive loading in the thoracolumbar spine. In summary, by using advanced musculoskeletal modeling to estimate vertebral loading throughout the spine, this study provides a biomechanical mechanism for the higher incidence of fractures in thoracolumbar vertebrae compared to other spinal regions. © 2017 American Society for Bone and Mineral Research.
Acetylenic bond participation in biogenetic-like olefinic cyclizations in nitroalkane solvents. Facile total synthesis of dl-testosterone benzoate (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcetylenic bond participation in biogenetic-like olefinic cyclizations in nitroalkane solvents. Facile total synthesis of dl-testosterone benzoateDouglas R. Morton and William S. JohnsonCite this: J. Am. Chem. Soc. 1973, 95, 13, 4419–4420Publication Date (Print):June 27, 1973Publication History Published online1 May 2002Published inissue 27 June 1973https://doi.org/10.1021/ja00794a047Request reuse permissionsArticle Views126Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (277 KB) Get e-Alertsclose Get e-Alerts
Petroleum refining. Technology and economics. Volume 5 (1975)

This book presents the basic aspects of current petroleum refining technology and economics in a systematic manner. The physical and chemical properties of petroleum and petroleum products are described, along with major modern refining processes. Data for determination of product yields, investment, and operating costs are presented for all major refining processes. Similar data also are given for supporting processes, such as hydrogen generation and elemental sulfur recovery. Ecological problems of petroleum refining operations are described in general terms. Reaction chemistry is described in basic terms with reference to desirable thermodynamic conditions. Capital cost data have been updated to 1973 and are presented on a consistent basis with respect to location, utilities, offsites, and other items. A simplified procedure for developing reasonably accurate investment and operating cost data is given. The yield data for reaction processes have been extended to allow complete material balances to be made from physical properties. Insofar as possible, data for catalytic reactions represent average yields from competing proprietary catalysts and processes. The yield data combined with the cost data will serve the practicing engineer and refinery management as a convenient tool for developing preliminary economic feasibility studies. Examples of such calculations are given as anmore » aid to students.« less
Antibodies to Prothrombin, Factor V, and β2-Glycoprotein I and Vascular Access Thrombosis (2001)

We studied 88 hemodialysis patients for the presence of antibodies to human factor II (hFII), bovine factor V (bFV), and human beta2-glycoprotein 1 (beta2GPI). Forty-one patients had elevated anti-hFII antibodies, 17 had elevated anti-bFV antibodies, and 9 had elevated anti-beta2GPI antibodies. Fifty-two patients had elevated antibodies to one or more protein. Patients with PTFE grafts had elevated antibodies most frequently (21 [75%] vs. 20 fistulas [45%; p = 0.016 compared with PTFE] and 11 tunneled catheters [68.8%]). Twelve of 13 patients (92.3%) with PTFE grafts and thrombosis had elevated antibody levels, compared with 9 of 15 without thrombosis (60%; p = 0.049). The number of thromboses and mean thrombosis rates were significantly higher in PTFE patients with antibodies (1.24 vs. 0.14 thromboses, p < 0.01; 42.67 vs. 6.44 thromboses/100 patient years, p < 0.05). When analyzed individually, thrombotic complications occurred more frequently in patients with PTFE grafts and elevated anti-bFV antibodies (p = 0.016), but did not correlate with anti-hFII or anti-beta2GPI antibodies. Thrombotic complications did not correlate with elevated antibody levels in patients with AV fistulas or cuffed catheters. In conclusion, hemodialysis patients with PTFE grafts frequently have elevated antibodies to FII, FV, and beta2GPI, and the presence of elevated antibody levels to one or more of these proteins is associated with an increased thrombotic risk. Further studies are necessary to determine whether limiting exposure to bovine thrombin preparations will decrease the incidence of these antibodies and PTFE graft thrombosis.
Comparison of Radiation Element Method and Discrete Ordinates Interpolation Method Applied to Three-Dimensional Radiative Heat Transfer (2005)

This paper compares and scrutinizes the characteristics of radiation element method by ray emission model (REM2) and discrete ordinates interpolation method (DOIM). A three-dimensional radiative heat transfer problem is solved within a rectangular enclosure containing absorbing, emitting, nonscattering medium with temperatures given as a sine function. The calculation results are validated with the zonal results and the analytical solution. Generally, the calculation results agree well with the exact solution. However, when the optically thickness is much larger than unity, the zonal and REM2 results overestimate the heat source strength and wall heat flux, and when it is small, DOIM results underestimate them. The reasons and remedies are carefully discussed.
Hydrographical and Biological Conditions in the North Sea as Indicated by Plankton Organisms (1939)

Journal Article Hydrographical and Biological Conditions in the North Sea as Indicated by Plankton Organisms Get access F. S. Russell F. S. Russell Search for other works by this author on: Oxford Academic Google Scholar ICES Journal of Marine Science, Volume 14, Issue 2, August 1939, Pages 171–192, https://doi.org/10.1093/icesjms/14.2.171 Published: 01 August 1939
Main Campus: Summer 2012 (2012)

1:00-4:00 1:00-4:00 1:00-4:00 1:00-4:00 1:00-4:00 MATH 030(E) 9:00-4:00 9:00-4:00 9:00-4:00 9:00-4:00 1:00-4:00 MATH 060 9:00-4:00 9:00-4:00 9:00-4:00 9:00-4:00 1:00-4:00 MATH 090(E) 9:00-4:00 9:00-4:00 9:00-4:00 9:00-4:00 1:00-4:00 MATH 091(E) 9:00-4:00 9:00-4:00 9:00-4:00 9:00-4:00 1:00-4:00 MATH 110 9:00-4:00 9:00-4:00 9:00-4:00 9:00-4:00 1:00-4:00 PHIL 110 11:30-1:30 11:30-1:30 11:30-1:30 11:30-1:30 SPCH 102 11:30-1:30 11:30-1:30 11:30-1:30 11:30-1:30 STAT 200 11:30-2:30 11:30-2:30 11:30-2:30 11:30-2:30
Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells (2002)

T helper 2 (Th2) cytokines interleukin (IL)-4 and IL-13, which activate signal transducer and activator of transcription 6 (STAT6) are expressed in the muscularis externa during nematode infection and are candidate mediators of the associated hypercontractility. To determine the locus of action of these cytokines, we examined the IL-4- and IL-13-induced hypercontractility of the isolated muscle cells from STAT6 +/+ and STAT6 -/- mice. We compared the results with cells isolated from Trichinella spiralis-infected STAT6 +/+ and STAT6 -/- mice. Carbamylcholine chloride (Carbachol) induced the contraction of jejunal muscle cells in a concentration-dependent manner maximal contraction (R(max) 26.7 +/- 1.9%). Cells from T. spiralis-infected STAT6 -/- mice showed the hypertrophy (cell lengths 41.4 +/- 0.8 to 89.0 +/- 8.7 microm) and hypercontractility (R(max) 37.5 +/- 1.3%) induced by infection. IL-4Ralpha mRNA was detected in dispersed smooth muscle cells. Incubation of longitudinal muscle-myenteric plexus (LMMP) with IL-4 and IL-13 enhanced Carbachol-induced muscle contraction (R(max) 35.5 +/- 1.9 and 32.4 +/- 2.9%, respectively). Incubation of LMMP from STAT6 -/- mice with IL-4 did not enhance the contraction. The hypercontractility in T. spiralis-infected mice was attenuated in STAT6 -/- mice (P < 0.02). These results indicate both IL-4 and IL-13 induce hypercontractility of muscle cells via the STAT6 pathway, and this is the basis for hypercontractility observed in T. spiralis-infected mice.
Nuclear Magnetic Resonance in Beryllium (1967)

NMR of $^{9}\mathrm{Be}$ in beryllium metal powder has been measured from 5 to 20 kG at 295\ifmmode^\circ\else\textdegree\fi{}K. The isotropic Knight shift is measured as (-0.0027\ifmmode\pm\else\textpm\fi{}0.0006)%; the anisotropic Knight shift $|a|<0.0003%$; and the quadrupole coupling $\frac{{e}^{2}\mathrm{qQ}}{h}$ is measured as 56.4\ifmmode\pm\else\textpm\fi{}0.3 kc/sec.
Case Analysis of Auction Market in Brisbane Housing System (2006)

Only recently, the average Australian residential property market was experiencing negative growth caused by the decrease of average housing prices in the major capital cities, in particular, Sydney and Melbourne. However, other cities were registering positive growth. In a decade, the average house price in Brisbane has increased by more than 150 per cent. In 1994, the highest average house price in Brisbane was around $310,000 but in 2004 it reached $780,000. The high appreciation expectation has also influenced the choice of housing transaction method. In a boom market, auction in Sydney and Melbourne contribute a certain level of residential property market share. In Sydney, there was 50 per cent of all real estate sold by auction marketing. During the same boom period, the Brisbane auction market only had 20 to 30 per cent market share. This initial study aims to explore Brisbane housing auction market and the risk/benefit analysis to stakeholders in the auction mechanism. This study analyses the results from in-depth interview of representative of stakeholders and recent sales data (mid August to early October 2005). It was also found that vendors gain more benefits than buyers in the auction market. However, the strict terms of conditions that apply in auction transactions relative to the private treaty sales have discouraged buyers from utilising the auction process.
[Surgical pathology in the era of molecular medicine]. (2009)

20世纪70年代初,分子生物学、细胞和分子遗传学的发展,已将这些新知识、新理论和新技术应用到人类疾病的研究,从而诞生了病理学的一个新的分支--分子病理学.核酸分子杂交、比较基因组杂交(CGH)、荧光原位杂交(FISH)、聚合酶链反应(PCR)及其衍生技术(如RT-PCR、定量PCR等)和DNA测序等技术逐渐渗入到外科病理学,并已应用于肿瘤的诊断和分型、肿瘤治疗选择和预后评估、遗传性疾病的诊断、感染性疾病的病原体证实等方面。
A Quantitative Comparison of the Antileukemic Effectiveness of Two Folic Acid Antagonists in Mice (1955)

A Quantitative Comparison of the Antileukemic Effectiveness of Two Folic Acid Antagonists in Mice Get access Abraham Goldin, Abraham Goldin Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar John M. Venditti, John M. Venditti Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Stewart R. Humphreys, Stewart R. Humphreys Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Don Dennis, Don Dennis Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nathan Mantel, Nathan Mantel Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Samuel W. Greenhouse Samuel W. Greenhouse Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 6, June 1955, Pages 1657–1664, https://doi.org/10.1093/jnci/15.6.1657 Published: 01 June 1955 Article history Received: 29 October 1954 Published: 01 June 1955
Complete inhibition of food-stimulated gastric acid secretion by combined application of pirenzepine and ranitidine. (1981)

In a double-blind, placebo controlled and randomised secretory study the effectiveness of pirenzepine, ranitidine, and their combination was compared intraindividually in eight healthy subjects receiving intravenous bolus injections. Pirenzepine (0.15 mg/kg) plus ranitidine (0.6 mg/kg) suppressed peptone-stimulated gastric acid secretion from 69 +/- 11 to 2 +/- 0.4 mmol H+/3 h; the mean percentage inhibition was 97%. Postprandial gastrin was unaffected. There were only minor side-effects in a few experiments (reduction of salivation, brief blurring of vision), but no prolactin stimulation after ranitidine or ranitidine plus pirenzepine. The combined application of ranitidine and pirenzepine inhibited meal-stimulated acid secretion more effectively and produced fewer side-effects than the combination of cimetidine plus pirenzepine studied previously.