gebhart/patrepeval huggingface dataset:
Angiotensin II mediates systemic rebound hypertension after cessation of prostacyclin infusion in sheep (1998)

Prostacyclin (or epoprostenol), an arachidonic acid metabolite, is an effective treatment for patients with primary pulmonary hypertension. Interruption of chronic prostacyclin infusion can result in recurrent symptoms of dyspnea and fatigue. The etiology of this phenomenon is unknown. We hypothesized that sympathoadrenal activation could lead to increased vascular tone after abrupt termination of the infusion. To evaluate this effect, we monitored six chronically instrumented, awake sheep during and after infusion of prostacyclin. Prostacyclin decreased mean arterial pressure (MAP) by 14% and increased cardiac output by 33%. After the infusion ceased, MAP rebounded 23% above baseline, and cardiac output decreased by 28% from peak values within 10 min. We were unable to demonstrate an increase in norepinephrine levels after cessation of prostacyclin, nor did alpha-adrenergic blockade affect postinfusion hemodynamics. However, plasma renin activity increased >10-fold at peak infusion and remained elevated for up to 2 h after discontinuation of prostacyclin. Coinfusion of the angiotensin II-receptor antagonist L-158,809 resulted in complete abrogation of the postcessation rise in MAP. We conclude that renin-angiotensin system activation is primarily responsible for systemic hypertension occurring after abrupt cessation of prostacyclin infusion in sheep and that angiotensin II receptor blockade prevents this response. Our data do not support a role for sympathetic nervous system activation in the systemic pressor response after prostacyclin infusion.
Commercially available fluorometers, luminometers and imaging devices for low‐light level measurements and allied kits and reagents: survey update 6 (1999)

This survey was compiled in May and June 1999 and includes products not covered in the previous six surveys since 1992. See Update 5 completed in July 1997 for references to previous surveys (Stanley PE, J Biolumin Chemilumin 1997; 12:61–78). Technical details are provided together with company address and contact information including email and website where known. Products include: Luminometers, radiometers, fluorometers (sometimes spelled fluorimeters), low-light imaging CCD cameras, kits and allied reagents and kits. Copyright © 1999 John Wiley & Sons, Ltd.
Circumferential propagation of acoustic boundary waves in boreholes (1982)

Dispersion equations are derived to describe the circumferential propagation of elastic boundary waves along an empty and a fluid-filled borehole. These equations are solved for various Poisson ratios to yield velocity and attenuation curves as a function of the ratio of wavelength to borehole diameter. Theoretical data agree closely with data obtained in an actual borehole.
Class-Selective Drug Detection:  Fluorescently-Labeled Calmodulin as the Biorecognition Element for Phenothiazines and Tricyclic Antidepressants (2002)

A small-scale, homogeneous, rapid sensing system for phenothiazines and tricyclic antidepressants (TCAs) has been developed by employing fluorescently labeled mutant calmodulin (CaM) as the recognition element. A calmodulin mutant containing a unique cysteine residue at position 109 on the protein was expressed in Escherichia coli. Following purification, the environment-sensitive, thiol-specific fluorophores N-[2-(1-maleimidyl)ethyl]-7-(diethylamino)coumarin-3-carboxamide (MDCC), 6-acryloyl-2-dimethylaminonaphthalene (acrylodan), and 4-[N-(2-(iodoacetoxy)ethyl)-N-methylamino]-7-nitrobenz-2-oxa-1,3-diazole (IANBD ester) were coupled to the C109 site of the mutant protein. The response of labeled CaM in the presence of calcium to increasing concentrations of chlorpromazine hydrochloride (CPZ), as well as other phenothiazines and structurally related antipsychotics and antidepressants, was investigated. Fluorescence measurements were performed on benchtop and microtiter plate fluorometers. The responses were characterized as a change in the signal intensity of the labeled protein upon ligand binding, and the stability of the system was monitored over a nine-month period. The assay showed specificity for the phenothiazine and TCA classes of drugs, with limits of detection in the micromolar range. Selectivity studies indicated negligible response of the biosensing system to structurally unrelated compounds. This work represents a proof-of-concept assay for rapid, homogeneous detection of drugs employing binding proteins as the biorecognition element.
Feasibility of Standardization of Serum C-Peptide Immunoassays with Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry (2006)

The ID-LC/tandem MS procedure is suitable for specific and accurate measurement of basal and stimulated serum concentrations of proinsulin C-peptide fragment 33-63 and is suitable for use in standardization of C-peptide immunoassays.
Thermally Active Hybridization Drives the Crystallization of DNA-Functionalized Nanoparticles (2013)

The selectivity of DNA recognition inspires an elegant protocol for designing versatile nanoparticle (NP) assemblies. We use molecular dynamics simulations to analyze dynamic aspects of the assembly process and identify ingredients that are key to a successful assembly of NP superlattices through DNA hybridization. A scale-accurate coarse-grained model faithfully captures the relevant contributions to the kinetics of the DNA hybridization process and is able to recover all experimentally reported to date binary superlattices (BCC, CsCl, AlB2, Cr3Si, and Cs6C60). We study the assembly mechanism in systems with up to 10(6) degrees of freedom and find that the crystallization process is accompanied with a slight decrease of enthalpy. Furthermore, we find that the optimal range of the DNA linker interaction strengths for a successful assembly is 12-16kBT, and the optimal mean lifetime of a DNA hybridization event is 10(-4)-10(-3) of the total time it takes to form a crystal. We also obtain the optimal percentage of hybridized DNA pairs for different binary systems. On the basis of these results, we propose suitable linker sequences for future nanomaterials design.
Simulation of Ultrasonic and Electromagnetic Nondestructive Evaluation of Corrosion (2003)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. Spies, A. Yashan, C. V. Kropas‐Hughes; Simulation of Ultrasonic and Electromagnetic Nondestructive Evaluation of Corrosion. AIP Conf. Proc. 27 March 2003; 657 (1): 367–374. https://doi.org/10.1063/1.1570159 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
An Evaluation of Organizational Due Process in the Resolution of Employee/Employer Conflict (1981)

John D. Aram, Paul F. Salipante, Jr., An Evaluation of Organizational Due Process in the Resolution of Employee/Employer Conflict, The Academy of Management Review, Vol. 6, No. 2 (Apr., 1981), pp. 197-204
Differential lung ventilation after unilateral hydrochloric acid aspiration in the dog (1983)

Differential lung ventilation (DLV) may be necessary in the supportive care of patients with severe unilateral or asymmetrical lung disease. The best method for allocating tidal volume between the 2 lungs is unknown. Eighteen mongrel dogs were given a unilateral hydrochloric acid (HCI) aspiration injury. A computer-controlled differential lung ventilation system was used to ventilate 6 dogs with equal volumes in each lung, 6 dogs with equal end-inspiratory pressure in each lung, and 6 dogs with equal end-tidal CO2 fraction in each lung. The computer allocated volume between the 2 lungs by these 3 schemes on a breath-by-breath basis and maintained PaCO2 at 35 torr and total tidal volume at 15 ml/kg. Oxygen tension fell and pulmonary venous admixture increased after aspiration. There were no differences in gas exchange among the groups. Without PEEP, differential partitioning of tidal volume is of little consequence in differential lung ventilation of asymmetrical injuries.
Anaerobic Aryl Reductive Dehalogenation of Halobenzoates by Cell Extracts of “ <i>Desulfomonile tiedjei</i> ” (1990)

We studied the transformation of halogenated benzoates by cell extracts of a dehalogenating anaerobe, "Desulfomonile tiedjei." We found that cell extracts possessed aryl reductive dehalogenation activity. The activity was heat labile and dependent on the addition of reduced methyl viologen, but not on that of reduced NAD, NADP, flavin mononucleotide, flavin adenine dinucleotide, desulfoviridin, cytochrome c(3), or benzyl viologen. Dehalogenation activity in extracts was stimulated by formate, CO, or H(2), but not by pyruvate plus coenzyme A or by dithionite. The pH and temperature optima for aryl dehalogenation were 8.2 and 35 degrees C, respectively. The rate of dehalogenation was proportional to the amount of protein in the assay mixture. The substrate specificity of aryl dehalogenation activity for various aromatic compounds in "D. tiedjei" cell extracts was identical to that of whole cells, except differences were observed in the relative rates of halobenzoate transformation. Dehalogenation was 10-fold greater in "D. tiedjei" extracts prepared from cells cultured in the presence of 3-chlorobenzoate, suggesting that the activity was inducible. Aryl reductive dehalogenation in extracts was inhibited by sulfite, sulfide, and thiosulfate, but not sulfate. Experiments with combinations of substrates suggested that cell extracts dehalogenated 3-iodobenzoate more readily than either 3,5-dichlorobenzoate or 3-chlorobenzoate. Dehalogenation activity was found to be membrane associated. This is the first report characterizing aryl dehalogenation activity in cell extracts of an obligate anaerobe.
Functional connectivity changes with concentration of sevoflurane anesthesia (2005)

Low-frequency oscillations (<0.08 Hz) have been detected in functional magnetic resonance imaging studies, and appear to be synchronized between functionally related areas. The effect of anesthetic agents on cortical activity is not completely characterized. This study assessed the effect of anesthesia on the temporal relations in activity in the motor cortices. Resting-state magnetic resonance data were acquired on six volunteers under different anesthetic states (using 0.0%, 2.0% and 1.0% stable end-tidal sevoflurane). Across all volunteers, the number of significant voxels (p<2.5 x 10) in the functional connectivity maps was reduced by 78% for light anesthesia and by 98% for deep anesthesia, compared with the awake state. Additionally, significant correlations in the connectivity maps were bilateral in the awake state but unilateral in the light anesthesia state.
High Performance Computing, an open textbook (2010)

The purpose of this book is to teach new programmers and scientists about the basics of High Performance Computing. Too many parallel and high performance computing books focus on the architecture, theory and computer science surrounding HPC. This book speaks to the practicing chemistry student, physicist, or biologist who need to write and run their programs as part of their research. ¶ High Performance Computing, originally published by O’Reilly–but out of print since 2003, has been republished on Connexions. Book author Severance, Charles;, with his editor Mike Loukides, worked with O’Reilly to release the book under a CC-BY license, then coordinated with the Connexions staff to republish it.
Deep Cauchy Hashing for Hamming Space Retrieval (2018)

Due to its computation efficiency and retrieval quality, hashing has been widely applied to approximate nearest neighbor search for large-scale image retrieval, while deep hashing further improves the retrieval quality by end-to-end representation learning and hash coding. With compact hash codes, Hamming space retrieval enables the most efficient constant-time search that returns data points within a given Hamming radius to each query, by hash table lookups instead of linear scan. However, subject to the weak capability of concentrating relevant images to be within a small Hamming ball due to mis-specified loss functions, existing deep hashing methods may underperform for Hamming space retrieval. This work presents Deep Cauchy Hashing (DCH), a novel deep hashing model that generates compact and concentrated binary hash codes to enable efficient and effective Hamming space retrieval. The main idea is to design a pairwise cross-entropy loss based on Cauchy distribution, which penalizes significantly on similar image pairs with Hamming distance larger than the given Hamming radius threshold. Comprehensive experiments demonstrate that DCH can generate highly concentrated hash codes and yield state-of-the-art Hamming space retrieval performance on three datasets, NUS-WIDE, CIFAR-10, and MS-COCO.
Automatic Slip Status and Stand Detection in Real-Time Drilling (2019)

Abstract The drilling process can be broken down into various activities from top-level activities (e.g., drilling and tripping) to lower-level activities (e.g., in-slip, out-of-slip, making connection, and circulation). The detection of the fundamental drilling unit, a stand, is necessary and essential for recognizing and inferring drilling activities. A new method is proposed to detect slip status, pipe change, and drilling/tripping stands based on real-time streaming data. The slip status is a critical element because it indicates a connection is made before drilling or tripping a stand. The proposed method is designed to infer the slip status with hookload, standpipe pressure (SPPA), and surface torque (STOR) sensor data. Specifically, the logic using hookload includes two criteria, a hookload standard deviation criterion and a dynamic hookload threshold criterion. This allows addressing the limitations of prior methods at shallow depth and using a manual threshold, which prevents the full automation of slip detection. In addition, the slip status can be confirmed or corrected with a logic using a combination of SPPA and STOR data. Then, a check is performed on whether a stand is added or removed during in-slip period. If needed, the stand detection can also be run to detect where a stand begins and ends. The method has been extensively tested and validated on many land and deepwater wells with drilling/tripping operations. Without human intervention, the dynamic hookload threshold can be determined automatically and adaptively after one or two drilling or tripping stands. Moreover, the hookload standard deviation criterion works well to detect the change of slip status at shallow depth. It is shown that high accuracy of detection can be achieved when the streaming data have a proper range of sampling rate. The new method addresses two limitations of the existing methods: (1) it automatically determines the dynamic hookload thresholds and eliminates the need of setting up the hookload threshold manually, and (2) it improves the accuracy of slip status and stand detection at shallow depth. This innovative work enables the automation of the slip status and stand detection process in batch runs or in real time without operator input.
Identification of angiotensin II receptor subtypes in human brain (1991)

The present study assessed the binding characteristics of [125I]angiotensin II to slices of human cerebellum adhered to glass slides using quantitative receptor autoradiography. Specific [125I]angiotensin II binding, defined by the inclusion of unlabelled angiotensin II (1.0 microM), was detected in the molecular layer of the cerebellum (0.09 +/- 0.02 fmol/mg tissue equivalent, mean +/- s.e.m., n = 3). The angiotensin II-2 receptor subtype selective ligand, PD123177, competed for approximately 65% of the specific binding in the molecular layer whilst the remainder of the specific binding was displaced by the angiotensin II-1 receptor subtype selective ligand, DuP753. It is concluded that angiotensin II receptor subtypes exist in human brain tissue and provide potential therapeutic sites of action.
Bradykinin stimulates Ca2+ entry via nitrendipine-sensitive Ca2+ channels in cultured human fibroblasts. (1992)

Bradykinin stimulates Ca2+ entry in cultured human fibroblasts via nitrendipine-sensitive Ca2+ channels in cultured human fibroblasts. The Ca2+ entering via this pathway does not contribute directly to the elevation of cytosolic Ca2+, but rather appears to be specifically taken up into an internal Ca2+ pool.
Predictions of RNA-binding ability and aggregation propensity of proteins (2014)

RNA-binding proteins (RBPs) control the fate of a multitude of coding and non-coding transcripts. Formation of ribonucleoprotein (RNP) complexes fine-tunes regulation of post-transcriptional events and influences gene expression. Recently, it has been observed that non-canonical proteins with RNA-binding ability are enriched in structurally disordered and low-complexity regions that are generally involved in functional and dysfunctional associations. Therefore, it is possible that interactions with RNA protect unstructured protein domains from aberrant associations or aggregation. Nevertheless, the mechanisms that prevent protein aggregation and the role of RNA in such processes are not well understood. In this work, I will describe algorithms that I have developed to predict protein solubility and to estimate the ability of proteins and transcripts to interact. I will illustrate applications of computational methods and show how they can be integrated with high throughput approaches. The overarching goal of my work is to provide experimentalists with tools that facilitate the investigation of regulatory mechanisms controlling protein homeostasis.
Study and simulation of CMOS LC oscillator phase noise and jitter (2003)

In this work we review the processes of phase noise and jitter in electronic oscillators and the relationship between the two. Frequency and time domain simulation techniques and results are presented through the study of performance enhancement for a CMOS LC oscillator. The studied enhancements significantly reduce flicker noise upconversion, while the results demonstrate good agreement between time and frequency domain design approaches.
A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3 (2008)

The T1DGC 6K SNP scan and follow-up studies reported here confirm previously reported type 1 diabetes associations at INS, IFIH1, and KIAA0350 and identify an additional disease association on chromosome 21q22.3 in the UBASH3A locus (OR 1.10 [95% CI 1.07-1.13]; P = 4.4 x 10(-12)). This gene and its flanking regions are now validated targets for further resequencing, genotyping, and functional studies in type 1 diabetes.
Support Vector Machine Learning for Region-Based Image Retrieval with Relevance Feedback (2007)

ABSTRACTWe present a relevance feedback approach based on multi-class support vector machine (SVM) learning and cluster-merging which can significantly improve the retrieval performance in region-based image retrieval. Semantically relevant images may exhibit various visual characteristics and may be scattered in several classes in the feature space due to the semantic gap between low-level features and high-level semantics in the user's mind. To find the semantic classes through relevance feedback, the proposed method reduces the burden of completely re-clustering the classes at iterations and classifies multiple classes. Experimental results show that the proposed method is more effective and efficient than the two-class SVM and multi-class relevance feedback methods.
GraphDice: A System for Exploring Multivariate Social Networks (2010)

Abstract Social networks collected by historians or sociologists typically have a large number of actors and edge attributes. Applying social network analysis (SNA) algorithms to these networks produces additional attributes such as degree, centrality, and clustering coefficients. Understanding the effects of this plethora of attributes is one of the main challenges of multivariate SNA. We present the design of GraphDice, a multivariate network visualization system for exploring the attribute space of edges and actors. GraphDice builds upon the ScatterDice system for its main multidimensional navigation paradigm, and extends it with novel mechanisms to support network exploration in general and SNA tasks in particular. Novel mechanisms include visualization of attributes of interval type and projection of numerical edge attributes to node attributes. We show how these extensions to the original ScatterDice system allow to support complex visual analysis tasks on networks with hundreds of actors and up to 30 attributes, while providing a simple and consistent interface for interacting with network data.
THE P<i>y</i> SCALE OF SOLVENT POLARITIES. SOLVENT EFFECTS ON THE VIBRONIC FINE STRUCTURE OF PYRENE FLUORESCENCE and EMPIRICAL CORRELATIONS WITH <i>E</i><sub>T</sub> and <i>Y</i> VALUES (1982)

Abstract— Pyrene fluorescence spectra have been run in 62 solvents of widely differing solvent polarity. As has been noted previously, the intensity ratio of the first (the 0–0 band) and third bands in vibronic fine structure of these spectra are very sensitive to solvent polarity. These I 1 / I 3 values, however, are not sensitive to hydrogen bonding aspects of solvent‐solute interactions. Correlations are reported with Winstein's Y values and with Dimrotb's E T values. On this basis the I 1 / I 3 values for pyrene fluorescence are suggested as the basis for a new empirical scale of solvent polarity, called the Py scale, which offers certain conveniences over other scales of solvent polarity.
Verschleißbeständige Fe‐Basislegierungen mit Niobkarbid (2004)

Abstract Martensitische Fe‐Basislegierungen des Systems Fe‐Cr‐C finden heute als Hartguss und Werkzeugstahl vielfältige Anwendung. Da ihre FeCr‐Karbide über eine relativ geringe Härte verfügen, wird in diesem Beitrag über neue Legierungen mit primär ausgeschiedenen härteren Niobkarbiden berichtet. Im Mittelpunkt stehen eine sekundär härtende, rissfrei aufschweißbare Hartlegierung, eine warmfester Schichtwerkstoff für Verbundguss, ein weißes Gusseisen und ein korrosionsbeständiger Kaltarbeitsstahl, die hinsichtlich ihrer herstellungsbedingten Gefüge analysiert und bezüglich Furchungsverschleiß untersucht wurden.
A 55ns CMOS EEPROM (1984)

A 32,768 (4K×8) CMOS EEPROM with a 55ns address access time will be discussed. Access time through the memory array was accomplished by using two memory cells per bit. A differential signal is generated on complementary bit lines to reduce the voltage swing necessary for sensing.
Glycopeptide Antibiotic Resistance (2002)

Glycopeptide antibiotics are integral components of the current antibiotic arsenal that is under strong pressures as a result of the emergence of a variety of resistance mechanisms over the past 15 years. Resistance has manifested itself largely through the expression of genes that encode proteins that reprogram cell wall biosynthesis and thus evade the action of the antibiotic in the enterococci, though recently new mechanisms have appeared that afford resistance and tolerance in the more virulent staphylococci and streptococci. Overcoming glycopeptide resistance will require innovative approaches to generate new antibiotics or otherwise to inhibit the action of resistance elements in various bacteria. The chemical complexity of the glycopeptides, the challenges of discovering and successfully exploiting new targets, and the growing number of distinct resistance types all increase the difficulty of the current problem we face as a result of the emergence of glycopeptide resistance.
A route to ethyl α-pentafluorobenzoyl-β-oxobutanoate via its copper(II) chelate (2001)

Ethyl 2-pentafluorobenzoyl-3-oxobutanoate has been prepared by the acylation of ethyl acetoacetate with pentafluorobenzoyl chloride via a copper(II) chelate.