gebhart/patrepeval huggingface dataset:
Lock-free data structure for multi-core processors (2010)

Real time control applications are very demanding in terms of closed loop system response. The challenge is to execute an operation in a predictable amount of time. As more control functions are needed, faster computing speed is preferred to achieve the desired control responses. The major processor manufacturers have given up trying to make processors run faster, at least for the time being. Instead, manufacturers are turning to multi-core architectures in which multiple processors (cores) communicate directly through shared hardware caches. Multi-core chips make computing more efficient by exploiting parallelism. This new paradigm is widely available and provides a new way of solving control problems. At the same time, the multi-core architecture poses a challenge because modern control systems are asynchronous: activities can be halted or delayed without warning by interrupts, preemption, and other events. In this paper, a lock-free linked-list queue is described and implemented on a multi-core ARM processor. The lock-free algorithm ensures threads that are competing for access to the queue do not have their execution indefinitely postponed by mutual exclusion; also system-wide progress is guaranteed.
Stem Cell Therapy for the Heart (2004)

Cellular cardiomyoplasty is an expanding field of research that involves numerous types of immature cells administered via several modes of delivery. The purpose of this review is to investigate the benefits of different types of cells used in stem cell research as well as the most efficient mode of delivery. The authors also present data showing that stem cells isolated from bone marrow are present at both 2 weeks and 3 months after engraftment in a myocardial infarction. These cells express muscle markers at both time points, which suggests that they have begun to differentiate into cardiomyocytes. Several questions must be answered, however, before stem cells can be used routinely in the clinic. Once these questions have been addressed, the use of stem cells in clinical practice can be realized.
DETERMINISTIC STORAGE OF LIQUID PLUGS IN MICROFLUIDIC CHANNELS USING PASSIVE VALVES (2008)

This work describes a microfluidic device that is capable of sorting liquid plugs and storing them into pockets without actuators (active valves). We programmed the deterministic fluid flow using burst-valves with different geometries.
Schedulability analysis of applications with stochastic task execution times (2004)

In the past decade, the limitations of models considering fixed (worst-case) task execution times have been acknowledged for large application classes within soft real-time systems. A more realistic model considers the tasks having varying execution times with given probability distributions. Considering such a model with specified task execution time probability distribution functions, an important performance indicator of the system is the expected deadline miss ratio of the tasks and of the task graphs. This article presents an approach for obtaining this indicator in an analytic way. Our goal is to keep the analysis cost low, in terms of required analysis time and memory, while considering as general classes of target application models as possible. The following main assumptions have been made on the applications that are modeled as sets of task graphs: the tasks are periodic, the task execution times have given generalized probability distribution functions, the task execution deadlines are given and arbitrary, the scheduling policy can belong to practically any class of non-preemptive scheduling policies, and a designer supplied maximum number of concurrent instantiations of the same task graph is tolerated in the system. Experiments show the efficiency of the proposed technique for monoprocessor systems.
Parameter estimation for text analysis (2009)

Abstract. Presents parameter estimation methods common with discrete probability distributions, which is of particular interest in text modeling. Starting with maximum likelihood, a posteriori and Bayesian estimation, central concepts like conjugate distributions and Bayesian networks are reviewed. As an application, the model of latent Dirichlet allocation (LDA) is explained in detail with a full derivation of an approximate inference algorithm based on Gibbs sampling, including a discussion of Dirichlet hyperparameter estimation. Finally, analysis methods of LDA models are discussed.
Neuroendocrinology of the Skin1 (2000)

The classical observations of the skin as a target for melanotropins have been complemented by the discovery of their actual production at the local level. In fact, all of the elements controlling the activity of the hypothalamus-pituitary-adrenal axis are expressed in the skin including CRH, urocortin, and POMC, with its products ACTH, alpha-MSH, and beta-endorphin. Demonstration of the corresponding receptors in the same cells suggests para- or autocrine mechanisms of action. These findings, together with the demonstration of cutaneous production of numerous other hormones including vitamin D3, PTH-related protein (PTHrP), catecholamines, and acetylcholine that share regulation by environmental stressors such as UV light, underlie a role for these agents in the skin response to stress. The endocrine mediators with their receptors are organized into dermal and epidermal units that allow precise control of their activity in a field-restricted manner. The skin neuroendocrine system communicates with itself and with the systemic level through humoral and neural pathways to induce vascular, immune, or pigmentary changes, to directly buffer noxious agents or neutralize the elicited local reactions. Therefore, we suggest that the skin neuroendocrine system acts by preserving and maintaining the skin structural and functional integrity and, by inference, systemic homeostasis.
Fatigue testing of short-link chain under line-loading conditions (1970)

Theory predicts that the position of maximum stress in short-link chain loaded elastically in tension is the crown, and this suggests that fatigue failures should occur there. In contrast, recent experimental work has shown that fatigue failures in these links occur at the junctions of intrados with straight sides, and photoelastic studies have confirmed that this is the position of maximum stress. This discrepancy is thought to be due to the fact that the theory assumes point loading between adjacent links and takes no account of ‘bedding down’ of the links. In the present work, bedding down has been minimized by the use of line loading, and crown failures have been obtained during fatigue cycling below the elastic limit.
Structural MRI correlates of recognition memory in Alzheimer's disease (1998)

Neuroimaging and lesion studies have demonstrated that hippocampal volume correlates with memory performance, but material-specific lateralization of this structure-function relationship has been inconsistent. This MRI study examined the relative contributions of left and right temporal lobe volumes to verbal and nonverbal recognition memory in a group of 20 Alzheimer's disease (AD) patients. There was a significant relationship between extent of right hippocampal and right temporal gray matter tissue volume deficit and performance on the face recognition subtest of the Warrington Recognition Memory Test. The face recognition test correlated with right hemisphere volume but not to left, indicating a material-specific relationship between brain structure and function in this patient group. Right temporal horn volume did not account for a significant proportion of variance in face recognition memory. Although word recognition was not significantly correlated with either left or right hippocampal volume in the total group, there was a strong correlation between left hippocampal volume and word recognition memory in the female AD patients. Thus, face recognition shows a material specific relationship with select lateralized hippocampal and temporal cortical volumes in AD patients, regardless of gender, whereas the verbal recognition-left-hippocampal volume relationship may be mediated by gender.
[Relationship of the CDKAL1 and KCNQ1 gene polymorphisms to the age at diagnosis of type 2 diabetes in the Slovakian population]. (2011)

In the present study, no relationship of CDKAL1 and KCNQ1 polymorphisms to the earlier onset of type 2 diabetes was observed.
Biofilm Formation in <i>Pseudomonas aeruginosa</i> : Fimbrial <i>cup</i> Gene Clusters Are Controlled by the Transcriptional Regulator MvaT (2004)

Pseudomonas aeruginosa is an opportunistic bacterial pathogen which poses a major threat to long-term-hospitalized patients and individuals with cystic fibrosis. The capacity of P. aeruginosa to form biofilms is an important requirement for chronic colonization of human tissues and for persistence in implanted medical devices. Various stages of biofilm formation by this organism are mediated by extracellular appendages, such as type IV pili and flagella. Recently, we identified three P. aeruginosa gene clusters that were termed cup (chaperone-usher pathway) based on their sequence relatedness to the chaperone-usher fimbrial assembly pathway in other bacteria. The cupA gene cluster, but not the cupB or cupC cluster, is required for biofilm formation on abiotic surfaces. In this study, we identified a gene (mvaT) encoding a negative regulator of cupA expression. Such regulatory control was confirmed by several approaches, including lacZ transcriptional fusions, Northern blotting, and transcriptional profiling using DNA microarrays. MvaT also represses the expression of the cupB and cupC genes, although the extent of the regulatory effect is not as pronounced as with cupA. Consistent with this finding, mvaT mutants exhibit enhanced biofilm formation. Although the P. aeruginosa genome contains a highly homologous gene, mvaU, the repression of cupA genes is MvaT specific. Thus, MvaT appears to be an important regulatory component within a complex network that controls biofilm formation and maturation in P. aeruginosa.
TRANSIENT ENCODING OF AUDIO SIGNALS USING DYADIC APPROXIMATIONS (2007)

In this paper, we present a frame based approach for transient detection and encoding of audio signals. The transient detection procedure, as presented here, uses linear prediction within a signal frame followed by an envelope estimation to build an adaptive threshold. Detected transients will automatically be separated and the gaps left by the removed transient are filled with samples from forward and backward extrapolation. To encode detected transients, dyadic approximation approaches are discussed. Results of the application to different audio signals are also presented. 1.
LSTM-Based Deep Learning Model for Civil Aircraft Position and Attitude Prediction Approach (2019)

With the rapid development of civil aviation, the contradiction between limited airspace resources and increasing traffic flow is intensifying, which raises the development request of modern air traffic management system apparently. Meanwhile, as one of the core parts of modern air traffic management system, aircraft trajectory prediction subsystem is becoming more and more important. Long Short-Term Memory (LSTM), is a sort of recurrent neural networks (RNN). It possesses the advantages of high accuracy, easy to implement and suitable for solving the problem of time series data prediction. In this paper, the prediction approach of civil aircraft trajectory based on LSTM Deep Neural Network is proposed aiming at the requirements of accuracy and real-time of aircraft trajectory prediction under the character of multi-dimensional. Via this method, we can get the prediction of the aircraft position and attitude at the same time. The experimental results show that the prediction based on LSTM model is superior to the traditional method in prediction of aircraft trajectory.
Fast, reconfigurable InP digital optical switches (1993)

Digital optical switches (DOS’s),1 initially demonstrated in LiNbO3 (Ref. 2) and more recently in InP (Ref. 3), show great potential for photonic-switching applications thanks mainly to extended optical bandwidth (>50 nm), polarization insensitivity, and ease of control because of their digital response. Routing applications are already foreseen and have motivated the fabrication of both LiNbO3 (Ref. 4) and InP (Ref. 5) polarization-insensitive 4×4 matrix switches. However, high-speed operation, which would enlarge the potential use of these devices towards synchronous packet and ATM switching, has not been demonstrated. We report, for the first time to our knowledge, InP DOS devices that, depending on the control mode, exhibit switching times ranging from a few nanoseconds down to 300 ps.
Isolation of a normal B cell subset with a Burkitt‐like phenotype and transformation <i>in vitro</i> with Epstein‐Barr virus (1988)

Epstein-Barr virus (EBV) is causally linked with endemic Burkitt's lymphoma (BL), a tumor whose homogeneous cell surface phenotype suggests derivation from a particular subset of activated germinal centre B cells in vivo. Endemic BL also shows an unusual form of EBV infection with down-regulation of certain of the virus latent proteins which are constitutively expressed when EBV infects and transforms normal resting B cells in vitro. Here we question whether this virus:cell interaction is unique to malignant BL cells or whether it might be reproduced by in vitro infection of those particular germinal centre cells displaying the BL-like phenotype. Firstly, we show by biochemical means that a subset of normal tonsillar B cells does indeed express the globotriaosylceramide glycolipid BLA and the common acute lymphoblastic leukaemia antigen CALLA, 2 important markers of the BL phenotype. Secondly, using 2-colour immunofluorescence labelling with anti-BLA and anti-CALLA monoclonal antibodies (MAbs), 4 subsets of low buoyant density tonsillar B cells (BLA+ CALLA+, BLA+ CALLA-, BLA- CALLA+, BLA- CALLA-) have been separated by means of a FACS and tested for their susceptibility to EBV-induced growth transformation in a limiting dilution assay. The BLA+ CALLA+ (i.e., BL-like) subset contained the highest proportion of cells already actively in cycle in vivo and gave the lowest yield of transformants, perhaps reflecting the greater efficiency with which EBV transforms resting target cells. Of the cell lines established from the BLA+ CALLA+ population, a significant number retained BLA expression but CALLA was always lost. In 2 further respects, these lines resembled conventional in vitro transformants rather than lines of BL type; thus the cells expressed cellular "activation" antigens (CD23, CD39, CD30, Ki-24) characteristic of the lymphoblastoid phenotype and contained the full spectrum of EBV latent proteins.
<title>Application of lasers in endodontics</title> (1997)

Root canal treatment is still a problem in dentistry. Very often the conventional treatment fails and several treatment sessions are necessary to save the tooth from root resection or extraction. Application of lasers may help in this situation. Bacteria reduction has been demonstrated both in vitro and clinically and is either based on laser induced thermal effects or by using an ultraviolet light source. Root canal cleansing is possible by Er:YAG/YSGG-Lasers, using the hydrodynamic motion of a fluid filled in the canals. However root canal shaping using lasers is still a problem. Via falsas and fiber breakage are points of research.
Bile Acid Synthetic Defects and Liver Disease: A Comprehensive Review (2002)

Annular elastolytic giant cell granuloma is a granulomatous process that presents as slowly growing annular papules and plaques on sun-exposed skin. It was first described in patients in the fourth and fifth decades of life. These lesions are primarily distributed on the head and neck. A review of the literature shows a preponderance of cases in adults. We report two cases of annular elastolytic giant cell granuloma developing in children under the age of 11 years.
A 110-Kilodalton Subunit of Translation Initiation Factor eIF3 and an Associated 135-kilodalton Protein Are Encoded by theSaccharomyces cerevisiae TIF32 and TIF31Genes (1999)

Translation initiation factor eIF3 is a multisubunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. In the yeast Saccharomyces cerevisiae eIF3 comprises up to 8 subunits. Using partial peptide sequences generated from proteins in purified eIF3, we cloned the TIF31 and TIF32 genes encoding 135- (p135) and 110-kDa (p110) proteins. Deletion/disruption of TIF31 results in no change in growth rate, whereas deletion of TIF32 is lethal. Depletion of p110 causes a severe reduction in cell growth and protein synthesis rates as well as runoff of ribosomes from polysomes, indicative of inhibition of the initiation phase. In addition, p110 depletion leads to p90 co-depletion, whereas other eIF3 subunit levels are not affected. Immunoprecipitation or nickel affinity chromatography from strains expressing (His)6-tagged p110 or p33 results in the co-purification of the well characterized p39 and p90 subunits of eIF3 as well as p110 and p33. This establishes p110 as an authentic subunit of eIF3. In similar experiments, p135 and other eIF3 subunits sometimes, but not always, co-purify, making assignment of p135 as an eIF3 subunit uncertain. Far Western blotting and two-hybrid analyses detect a direct interaction of p110 with p90, p135 with p33, and p33 with eIF4B. Our results, together with those from other laboratories, complete the cloning and characterization of all of the yeast eIF3 subunits.
Filtering of seismic data in 1‐D using a wavelet packet transform (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Filtering of seismic data in 1‐D using a wavelet packet transformAuthors: Andrew J. DeighanDoyle R. WattsAndrew J. DeighanDepartment of Geology and Applied Geology, University of Glasgow, UK and Doyle R. WattsDepartment of Geology and Applied Geology, University of Glasgow, UKhttps://doi.org/10.1190/1.1885648 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885648FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Andrew J. Deighan and Doyle R. Watts, (1997), "Filtering of seismic data in 1‐D using a wavelet packet transform," SEG Technical Program Expanded Abstracts : 1322-1325. https://doi.org/10.1190/1.1885648 Plain-Language Summary PDF DownloadLoading ...
Geometric energy based analysis and controller design of hydraulic actuators applied in rolling mills (2003)

The two main goals of this contribution are to demonstrate the integration of hydraulic actuator systems with PCH systems and to discuss a modification of the well known input-output linearization in connection with PCH systems. We will show that this approach is closely related to the existence of so called Casimir functions in the PCH context. Finally, industrial measurements demonstrating the implemented control law will be presented.
Multi-Criteria Evaluation in User-Centric Distributed Scheduling Agents. (2006)

This position paper discusses the problem of locally evaluating and comparing candidate schedules, in the context of a distributed scheduling task operating in unbounded environments in which each agent selfishly
Thermic effect of food in lean and obese men. (1988)

A systemic reappraisal of the thermic effect of food was done in lean and obese males randomly fed mixed meals containing 0, 8, 16, 24, and 32 kcal/kg fat-free mass. Densitometric analysis was used to measure body composition. Preprandial and postprandial energy expenditures were measured by indirect calorimetry. The data show that the thermic effect of food was linearly correlated with caloric intake, and that the magnitude and duration of augmented postprandial thermogenesis increased linearly with caloric consumption. Postprandial energy expenditures over resting metabolic requirements were indistinguishable when comparing lean and obese men for a given caloric intake. Individuals, however, had distinct and consistent thermic responses to progressively greater caloric challenges. These unique thermic profiles to food ingestion were also independent of leanness or obesity. We conclude that the thermic effect of food increases linearly with caloric intake, and is independent of leanness and obesity.
Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases (2014)

Tissue inflammation results in the production of numerous reactive oxygen, nitrogen and chlorine species, in addition to the products of lipid and sugar oxidation. Some of these products are capable of chemically modifying amino acids. This in turn results in changes to the structure and function of proteins. Increasing evidence demonstrates that such oxidative post-translational modifications result in the generation of neo-epitopes capable of eliciting both innate and adaptive immune responses. In this paper, we focus on how free radicals and related chemical species generated in inflammatory environments modulate the antigenicity of self-proteins, resulting in immune responses which involve the generation of autoantibodies against key autoantigens in autoimmune diseases. As examples, we will focus on Ro-60 and C1q in systemic lupus erythematosus, along with type-II collagen in rheumatoid arthritis. This review also covers some of the emerging literature which demonstrates that neo-epitopes generated by oxidation are conserved, as exemplified by the evolutionarily conserved pathogen-associated molecular patterns (PAMPs). We discuss how these observations relate to the pathogenesis of both human autoimmune diseases and inflammatory disease, such as atherosclerosis. The potential for these neo-epitopes and the immune responses against them to act as biomarkers or therapeutic targets is also discussed.
Implicit Object Space Partitioning: The No-Memory BVH (2011)

We present a new ray tracing algorithm that requires no explicit acceleration data structure and therefore no memory. It is represented in a completely implicit way by triangle reordering. This new implicit data structure is simple to build, efficient to traverse and has a fast total time to image. The implicit acceleration data structure must be constructed only once and can be reused for arbitrary numbers of rays or ray batches without the need to rebuild the hierarchy. Due to the fast build times it is very well suitable for dynamic and animated scenes. We compare it to classic acceleration data structures, like a Bounding Volume Hierarchy, and analyze its effciency.
The immunogenicity, safety, and efficacy of etanercept liquid administered once weekly in patients with rheumatoid arthritis. (2007)

The 50 mg/mL liquid etanercept formulation administered once weekly was well tolerated. The incidence of anti-etanercept antibodies, the nature and frequency of adverse events, and improvements in signs and symptoms of RA and patient physical function were similar to those in previous etanercept studies.