gebhart/patrepeval huggingface dataset:
Advancing Treatment for Metastatic Bone Cancer: Consensus Recommendations from the Second Cambridge Conference (2008)

Priorities for research in bone biology include characterizing components of the stem cell niche in bone, developing oncogenic immunocompetent animal models of bone metastasis, and investigating the unique contribution of the bone microenvironment to tumor growth and dormancy. Priorities for research in preserving normal bone health include developing methods to measure and characterize disseminating tumor cells, assessing outcomes from the major prevention trials currently in progress, and improving methodologies to assess risks and benefits of treatment. Priorities for optimizing bone-targeted therapies include advancing studies of serum proteomics and genomics to reliably identify patients who will develop bone metastases, enhancing imaging for early detection of bone metastases and early response evaluation, and developing new tests to evaluate response to bone-directed treatments.
Acute Generalized Exanthematous Pustulosis due to Doxycycline (1993)

Sterile epidermal neutrophilic pustulation can be observed in a variety of diseases. Though drug hypersensitivity is an uncommon cause, it is yet a known entity to be considered in the differential diagnosis of generalized pustulosis. In a 40-year-old woman, who developed a generalized pustular eruption after starting on doxycycline therapy of bronchitis, the rash was concluded to be drug induced after exclusion of other pustular dermatoses. Sensitization to doxycycline was demonstrated by in vitro lymphocyte testing and correlated with clinical drug hypersensitivity after recurrence of the pustular eruption on nonintentional rechallenge with doxycycline.
The Kyushu University reconfigurable parallel processor (1989)

The reconfigurable parallel processor system under development at Kyushu University is an MIMD-type multiprocessor which consists of N processing-elements (currently N is 128) fully connected by S N × N crossbar networks (currently S is 1). Each PE (Processing Element) employs a Fujitsu SPARC MB86900/10 chip-set, a Weitek WTL1164/65 chip-set, an MMU (Memory Management Unit) with 64K bytes of cache, 4M bytes of memory, and an MCU (Message Communication Unit). The modular 128 × 128 crossbar network is implemented by arranging 256 identical 8 × 8 crossbar LSI-modules in a 16 × 16 matrix form. The full 128-PE configuration achieves supercomputer levels of performance by providing 1.28 GIPS and 205 MFLOPS of computing power, 512M bytes of memory, and 2.56G bytes/s of inter-PE communication bandwidth. At the same time, it exploits unique reconfigurability in the memory and intercommunication architectures. By utilizing these two types of reconfigurability, we believe that the system can be effectively tailored to a wide spectrum of applications such as numerical computation, image processing, computer graphics, artificial intelligence, neurocomputing, and so on.
First Synthesis of 2,3,6,7-Tetrabromonaphthalene Diimide (2007)

N,N'-Bis(n-octyl)-2,3,6,7-tetrabromonaphthalene diimide (TBNDI) was synthesized by a new imidization reaction and characterized by HRMS, (1)H NMR, (13)C NMR, elemental analyses, FT-IR, UV-vis, and single-crystal X-ray analysis. The TBNDIs are the key precursors for the synthesis of core-tetrasubstituted-naphthalene diimides.
Bubble Characteristics as They Pertain to Compressive Strength and Freeze-Thaw Durability (1988)

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Design and implementation of a pipelined 8 bit-serial single-flux-quantum microprocessor with cache memories (2007)

A pipelined 8 bit-serial single-flux-quantum microprocessor integrating cache memories, called CORE1γ, has been designed and implemented. The CORE1γ has 16 byte and 8 byte shift-register-based cache memories for instructions and for data, respectively. The microprocessor overlaps four instructions in pipeline executions. The pipeline stages are optimized to control the cache memories and a new circuit component is developed to manage the pipeline execution according to whether each cache hits or misses. Advanced passive transmission line techniques with use of the cell library of the 2.5 kA cm−2 niobium standard process are utilized to implement the CORE1γ accompanied by extremely complex interconnects. The CORE1γ is made up of 295 passive interconnects, and 22302 Josephson junctions are integrated on a 6.36 × 6.36 mm2 area. The logic simulation shows that the peak performance is estimated at 1000 million operations per second, and it is kept even during memory access as long as the cache memories hit.
A Fast-Switching Frequency Synthesizer for UWB Applications (2005)

A fast-switching frequency synthesizer is presented for ultra-wideband MB-OFDM applications. This synthesizer generates three frequency tones with 528 MHz spacing. By using single-sideband mixers with Q-enhancement bandpass filters and switched-cascode multiplexers, the sideband rejection is less than -30dB at least and the frequency switching time is less than 7ns. The chip has been fabricated in 0.18mum CMOS process and the area is 1.32mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . It consumed 70mW from a 1.8V supply
Evaluation of copper sulphate, formalin and peracetic acid in footbaths for the treatment of digital dermatitis in cattle (2002)

The efficacy of three non-antibiotic products (copper sulphate, formalin and peracetic acid) was compared with the efficacy of erythromycin, when the four substances were applied in footbaths for the treatment of cows with digital dermatitis. The cows were divided into four groups on the basis of their current housing and randomly allocated to one of the four treatments. Cattle allocated to the non-antibiotic treatments were footbathed daily for seven days, but the cattle treated with erythromycin were footbathed for two days only. Complete records were obtained for 252 lesions from 169 cows. There were significant reductions in the lesion scores of all four groups, but there was no significant effect of treatment and no significant interaction between treatment and time.
The preparation of methionine from caseinogen (1932)

Research Article| January 01 1932 The preparation of methionine from caseinogen Norman Wingate Pirie Norman Wingate Pirie 1The Biochemical Laboratory, Cambridge Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd © 1932 LONDON: CAMBRIDGE UNIVERSITY PRESS1932 Biochem J (1932) 26 (4): 1270–1274. https://doi.org/10.1042/bj0261270 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Norman Wingate Pirie; The preparation of methionine from caseinogen. Biochem J 1 January 1932; 26 (4): 1270–1274. doi: https://doi.org/10.1042/bj0261270 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1932 LONDON: CAMBRIDGE UNIVERSITY PRESS1932 Article PDF first page preview Close Modal You do not currently have access to this content.
Accelerated transplant coronary artery disease. (1990)

H eart transplantation has become a clinically accepted procedure for the treatment of patients with end-stage heart disease. Since the first successful orthotopic transplantation of the canine heart, described by Lower and Shumway in 1960,’ and the first human heart transplant, performed by Barnard in 1967,’ there has been a gradual increase in the annual number of procedures performed worldwide, reaching 2,450 during the calendar year 1988.3 This increase, particularly marked since the introduction of cyclosporine-based immunosuppression in 1980, reflects increasing acceptance of the procedure because of improving survival rates. The l-year and 5-year survival rates, which for the period 1968-1974 were 48% and 18%, have risen to 81% and 55%, respectively, in the Stanford program.4 Infection and acute allograft rejection remain the most common early causes of death in transplant recipients, accounting for 38% and 25% respectively of deaths in the International Heart Transplant Registry.3 Improvements in the management of these complications are felt to account for the increasing survival rates. The development in many patients of a very diffuse and often rapidly progressive type of occlusive coronary artery disease (CAD), termed accelerated transplant coronary artery disease (TxCAD), is emerging as a major cause of morbidity and mortality among the increasing numbers of long-term heart transplant survivors. 5-7 In the Stanford series, 11% of patients who have died suffered fatal myocardial infarcts, congestive heart failure, or arrhythmias attributed to TxCAD,* and 19 patients underwent repeat cardiac transplantation because of advanced TxCAD.’ In this article, we will discuss the current status of knowledge about the prevalence of this disease, its angiographic and pathologic characteris-
Lineation in Complex Fold Systems (1957)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
My portal viewer for content fusion based on user's preferences (2005)

A novel Web application called "my portal viewer (MPV)" has been developed to provide Web users with higher quality content, which is needed due to a rapidly growing amount of content on the Web. It provides fused news to the user, based on two viewpoints, through a user friendly interface and the user's preferences. MPV automatically selects and merges content from many news pages, based on the user's interest and knowledge, after gathering these pages from various news Web sites. Our unique approach is that the layout of the MPV page is applied to the users' favorite news portal page and a part of the original content is replaced by the fused content. Whenever a user accesses an MPV page after browsing other news pages, he/she can acquire the desired content efficiently because MPV presents a refreshed page, based on the user's behavior, which reflects his/her interests and knowledge. In addition to the MPV framework, methods that are based on user reference for replacing and selecting have been developed using an HTML table model.
Characteristics of the New Station-Type Autovalve Lightning Arrester (1937)

Discussion and author's closure of a paper by W. G. Roman published on pages 819–22 of volume 56, 1937, AIEE TRANSACTIONS (July 1937 issue of ELECTRICAL ENGINEERING) and presented for oral discussion at the lightning protection session of the winter convention, New York, N. Y., January 25, 1938.
Rehabilitation of the Packers Falls Bridge (2001)

The Packers Falls Bridge was constructed in 1912 and consists of a 42' (12.8m) single span, reinforced concrete arch structure. This bridge was constructed using a unique forming system for its day, consisting of precast concrete rib sections that supported wood forms. The rib sections were ultimately cast-in and became an integral part of the concrete arch. This bridge is historically significant, in that it is the oldest surviving concrete ribbed arch in the state of New Hampshire. It is believed to have been designed by the faculty and students at the University of New Hampshire as one of the earliest concrete design courses offered by an engineering school in the country. The bridge remained unaltered until 1950, when the New Hampshire Department of Transportation (NHDOT) widened the bridge by adding rigid concrete frames on the upstream and downstream fascias. In the mid 1990's, significant concrete deterioration was observed on the underside of the arch and the load capacity of the structure was in question. A thorough field investigation, testing program, and structural analysis were performed. Field testing consisted of visual observations, sounding of concrete, and obtaining concrete cores to determine in-situ compression strength and density.
Stereology of arbitrary particles* (1986)

SUMMARY This paper deals with isolated, countable items, often termed particles, in three‐dimensional space. Its substance is the unbiased stereological estimation of the number, height, surface and volume of such particles without any assumptions about their shape . The full range of estimators is described, some of them for the first time, some in an improved form, several in more than one version, and all of them under the single, absolute requirement that one can in fact identify what one is quantifying on sections. In terms of the minimal number of sections for the analysis, the estimators may be classified as follows: On a single section it is possible to estimate v̄ V , the mean volume of particles in the volume‐weighted or ‘sieving’‐distribution. On two parallel sections, separated by a known distance, estimators exist of particle number and of all mean sizes (height, surface and volume) in the ordinary number distribution, as well as of SD N (v) , the standard deviation in the number distribution of particle volumes. If the containing space is relatively transparent the sections may be two optical sections within one thick physical section. On a stack of parallel sections, at least as high as the largest particle, and separated by known distances, one can get twelve mean sizes and twelve distributions of individual sizes: all combinations of three sizes: height, surface and volume in four different types of distributions: number, height, surface and volume. Fulfilling the sampling requirements of the above two estimation principles it has been shown very recently that by combining them one may even estimate mean sizes and number of arbitrary particles in a stack of sections with constant but unknown separation. Finally, a unique, unbiased estimator of the total number of items in a specimen is described for the use of which one need not measure the distance between sections, nor their thickness, nor the volume of the specimen, nor assume anything about shrinkage/swelling, sectioning compression or lost caps. It is the fractionator.
Osteoporosis in celiac disease and in endocrine and reproductive disorders (2008)

As the increase in lifespan brings to light diseases that were previously not clinically detectable, osteoporosis has become an issue of worldwide significance. The disease is marked by a loss of bone mass; the bones become less dense, fragile and more prone to fracturing. Because it is regulated by endocrine and environmental factors, osteoporosis presents a multifactorial etiopathogenesis, with the genetic component accounting for 70% of an individual variation in bone mass density (BMD), the principal determinant, with age, of fracture risk. Pathological conditions such as celiac disease (CD) exacerbate the process of bone loss, so that the occurrence of osteoporosis in celiac subjects is of particular note: indeed, the screening of osteoporosis patients for this disease is advisable, since it may be the only sign of undiagnosed CD. An increase in interleukin IL-1beta, of the IL-1 system, in the relatives of celiac patients confirms the genetic predisposition to osteoporosis and its presence is evidence of an association between the two conditions. The direct effect on the bones of CD is secondary to poor absorption of calcium and vitamin D. In women osteoporosis is indirectly associated with early menopause and amenorrhea, and it may follow prolonged breast-feeding and frequent pregnancies, while in men it is associated with hypogonadism and GH deficit. These endocrine and non-endocrine factors exert their effects on bones by modulating the RANK/RANK-L/OPG system. An appropriate lifestyle from adolescence onwards, together with early diagnosis of and treatment for CD and primary and secondary endocrine pathologies are important for the prevention of damage to the bones.
Isolated Microvessels from Human Brain (1987)

We evaluated activities of 5'-nucleotidase (5'-N), 3'-5'-phosphodiesterase (3'-5'-PDE), AchE, and ChAT on intraparenchymal blood vessels of a human brain. Brain vessels were isolated using the method which we developed. Fragments of human brain weighed 2 or 3g were minced and passed through 250μm nylon mesh. The material on the mesh was resuspended in buffer, after mild homogenization, passed through 73μm mesh. The mesh was washed, then the fluid was passed through 150μm mesh. Two vessel fractions were separated on the mesh and in the filtrate. The fraction on the mesh consisted primarily of larger vessels greater than arterioles, and that in the filtrate consisted predominantly of microvessels, which were purified by passing through a column of glass beads and centrifuged on sucrose density gradient. We evaluated the degree of contamination of isolated vessels using cerebroside as an indicator. The cerebroside level in these fractions was less than 5 percent of that in the brain homogenate.The activity of γGTP was significantly higher than that in the brain homogenate. These results indicate that enzyme activities are preserved well during the isolation procedure. 5'-N level was significantly lower in these fractions. 3'-5'-PDE level was significantly higher in the large vessel than in the small vessel fraction. Changes of these enzyme activities in the vessels may affect micro-circulation and blood brain barrier function via change in the concentration of adenosine and cyclic AMP. ChAT activity was very low in vessel fractions. AchE activity was significantly higher in both vessel fractions than in the brain homogenate, and in small vessel fraction than in the large vessel fraction. The discrepancy of these two enzyme activities in isolated vessels will provide a new tool and scope in studies on brain microvessels.
Interaction of the Postsynaptic Density-95/Guanylate Kinase Domain-Associated Protein Complex with a Light Chain of Myosin-V and Dynein (2000)

NMDA receptors interact directly with postsynaptic density-95 (PSD-95), a scaffold protein that organizes a cytoskeletal- signaling complex at the postsynaptic membrane. The molecular mechanism by which the PSD-95-based protein complex is trafficked to the postsynaptic site is unknown but presumably involves specific motor proteins. Here we demonstrate a direct interaction between the PSD-95-associated protein guanylate kinase domain-associated protein (GKAP) and dynein light chain (DLC), a light chain subunit shared by myosin-V (an actin-based motor) and cytoplasmic dynein (a microtubule-based motor). A yeast two-hybrid screen with GKAP isolated DLC2, a novel protein 93% identical to the previously cloned 8 kDa dynein light chain (DLC1). A complex containing PSD-95, GKAP, DLC, and myosin-V can be immunoprecipitated from rat brain extracts. DLC colocalizes with PSD-95 and F-actin in dendritic spines of cultured neurons and is enriched in biochemical purifications of PSD. Immunogold electron microscopy reveals a concentration of DLC in the postsynaptic compartment of asymmetric synapses of brain in which it is associated with the PSD and the spine apparatus. We discuss the possibility that the GKAP/DLC interaction may be involved in trafficking of the PSD-95 complex by motor proteins.
Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides (2002)

We have discovered two receptors for two different guests from a single dynamic combinatorial library. Each of the two guests amplifies the formation of a tightly binding host at the expense of unfit library members. Small differences in host-guest binding translate into useful differences in amplification. The selected hosts could be readily synthesized using biased dynamic libraries that contain only the right ratio of those building blocks that were selected by the guests. These results establish dynamic combinatorial chemistry as a practical method not only for the discovery but also for the synthesis of new receptors.
Protecting software code by guards (2013)

Abstract. Protection of software code against illegitimate modifications by its users is a pressing issue to many software developers. Many software-based mechanisms for protecting program code are too weak (e.g., they have single points of failure) or too expensive to apply (e.g., they incur heavy runtime performance penalty to the protected programs). In this paper, we present and explore a methodology that we believe can protect program integrity in a more tamper-resilient and flexible manner. Our approach is based on a distributed scheme, in which protection and tamper-resistance of program code is achieved, not by a single security module, but by a network of (smaller) security units that work together in the program. These security units, or guards, canbe programmed to do certain tasks (checksumming the program code is one example) and a network of them can reinforce the protection of each other by creating mutual-protection. We have implemented a system for automating the process of installing guards into Win32 executables 1. It is because our system operates on binaries that we are able to apply our protection mechanism to EXEs and DLLs. Experimental results show that memory space and runtime performance impacts incurred by guards can be kept very low (as explained later in the paper). 1
Analysis of inter- and intrafraction accuracy of a commercial thermoplastic mask system used for image-guided particle radiation therapy (2013)

The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of intrafraction time on positioning displacements. A total of 41 patients treated between January and July 2011 represented the study population. All the patients were immobilized with a tailored commercial thermoplastic head mask with standard head-neck rest (HeadSTEP(®), IT-V). Patient treatment position was verified by two orthogonal kilovoltage images acquired through a ceiling imaging robot (Siemens, Erlangen, Germany). The analysis of the applied daily corrections during the first treatment week before and after treatment delivery allowed the evaluation of the interfraction and intrafraction reproducibility of the thermoplastic mask, respectively. Concerning interfraction reproducibility, translational and rotational systematic errors (Σs) were ≤ 2.2 mm and 0.9º, respectively; translational and rotational random errors (σs) were ≤ 1.6 mm and 0.6º, respectively. Regarding the intrafraction accuracy translational and rotational Σs were ≤ 0.4 mm and 0.4º, respectively; translational and rotational σs were ≤ 0.5 mm and 0.3º, respectively. Concerning the time-intrafraction displacements correlation Pearson coefficient was 0.5 for treatment fractions with time between position checks less than or equal to median value, and 0.2 for those with time between position controls longer than the median figure. These results suggest that intrafractional patient motion is smaller than interfractional patient motion. Moreover, we can state that application of different imaging verification protocols translate into a relevant difference of accuracy for the same immobilization device. The magnitude of intrafraction displacements correlates with the time for short treatment sessions or during the early phase of long treatment delivery.