gebhart/patrepeval huggingface dataset:
A Review of Secure and Privacy-Preserving Medical Data Sharing (2019)

In the digital healthcare era, it is of the utmost importance to harness medical information scattered across healthcare institutions to support in-depth data analysis and achieve personalized healthcare. However, the cyberinfrastructure boundaries of healthcare organizations and privacy leakage threats place obstacles on the sharing of medical records. Blockchain, as a public ledger characterized by its transparency, tamper-evidence, trustlessness, and decentralization, can help build a secure medical data exchange network. This paper surveys the state-of-the-art schemes on secure and privacy-preserving medical data sharing of the past decade with a focus on blockchain-based approaches. We classify them into permissionless blockchain-based approaches and permissioned blockchain-based approaches and analyze their advantages and disadvantages. We also discuss potential research topics on blockchain-based medical data sharing.
Evaluation of the bistatic equivalence theorem for the near and far-field radar cross section of complex targets (1989)

This research examined the applicability of the monostatic-bistatic equivalence theorem (MBET) and associated extensions in determining the extent to which correlation exists between monostatic and bistatic data for both the near and far-field. A secondary objective was to determine whether reliable bistatic near-field radar cross section (RCS) data could be collected on a range originally designed to take monostatic far-field measurements. Dr. David Falconer developed two extensions of the MBET in an effort to estimate the bistatic RCS pattern in both the near and far-field by measuring the monostatic RCS pattern at one-half the bistatic angle, at a reduced frequency, and, for the near-field case, at an adjusted target-to-receiver separation range. The pattern representation and accuracy of these two extensions were examined by measuring the RCS of an ogive, a circular flat plate, and two circular cylinders of different lengths. Theses.
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis (2011)

We conclude that videographic gait analysis is an objective, sensitive and reproducible means of monitoring joint pathology in experimental murine OA, since stance time appears to correlate directly with OA severity. A single injection of HA prevents acute and prolonged gait changes and ameliorates the cartilage erosion and periarticular fibrosis normally seen in this model. We speculate that the capacity of HA to prevent cartilage erosion results from its normalization of joint biomechanics and its inhibitory effects on periarticular cells, which are involved in tissue hyperplasia and fibrosis. This effect of exogenous HA appears to mimic the protective effects of ablation of Adamts5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) on experimental murine OA, and we speculate that a common mechanism is involved.
A coherent Ising machine for 2000-node optimization problems (2016)

The analysis and optimization of complex systems can be reduced to mathematical problems collectively known as combinatorial optimization. Many such problems can be mapped onto ground-state search problems of the Ising model, and various artificial spin systems are now emerging as promising approaches. However, physical Ising machines have suffered from limited numbers of spin-spin couplings because of implementations based on localized spins, resulting in severe scalability problems. We report a 2000-spin network with all-to-all spin-spin couplings. Using a measurement and feedback scheme, we coupled time-multiplexed degenerate optical parametric oscillators to implement maximum cut problems on arbitrary graph topologies with up to 2000 nodes. Our coherent Ising machine outperformed simulated annealing in terms of accuracy and computation time for a 2000-node complete graph.
Contracts for System Design (2018)

Recently, contract-based design has been proposed as an “orthogonal” approach that complements system design methodologies proposed so far to cope with the complexity of system design. Contract-based design provides a rigorous scaffolding for verification, analysis, abstraction/refinement, and even synthesis. A number of results have been obtained in this domain but a unified treatment of the topic that can help put contract-based design in perspective was missing. This monograph intends to provide such a treatment where contracts are precisely defined and characterized so that they can be used in design methodologies with no ambiguity. In particular, this monograph identifies the essence of complex system design using contracts through a mathematical “meta-theory”, where all the properties of the methodology are derived from a very abstract and generic notion of contract. We show that the meta-theory provides deep and illuminating links with existing contract and interface theories, as well as guidelines for designing new theories. Our study encompasses contracts for both software and systems, with emphasis on the latter. We illustrate the use of contracts with two examples: requirement engineering for a parking garage management, and the development of contracts for timing and scheduling in the context of the Autosar methodology in use in the automotive sector.
Oestrogen induced suppression of collagen arthritis: I. Long term oestradiol treatment of DBA/1 mice reduces severity and incidence of arthritis and decreases the anti type II collagen immune response. (1987)

Experimental animal models can be used to help understand how oestrogen modulates autoimmune arthritis. We have previously shown that castration of female DBA/1 mice exaggerates arthritis induced with type II collagen. This report shows that treatment of castrated DBA/1 mice with low doses (0.2 micrograms twice a week) of beta-oestradiol reduces the incidence (37% vs 78% in controls) and severity (3.9 vs 5.6 mean scores) of arthritis. Levels of IgG anti type II collagen antibodies are decreased whereas levels of IgM antibodies are increased in the beta-oestradiol treated mice. The T cell response, as measured by a 3H-thymidine assay, is reduced in the beta-oestradiol treated mice. The results suggest that treatment with low doses of beta-oestradiol exerts a suppressive effect on both development of collagen arthritis as well as T cell dependent immune reactivity towards type II collagen.
A hybrid spatial–temporal deep learning architecture for lane detection (2022)

Accurate and reliable lane detection is vital for the safe performance of lane-keeping assistance and lane departure warning systems. However, under certain challenging circumstances, it is difficult to get satisfactory performance in accurately detecting the lanes from one single image as mostly done in current literature. Since lane markings are continuous lines, the lanes that are difficult to be accurately detected in the current single image can potentially be better deduced if information from previous frames is incorporated. This study proposes a novel hybrid spatial–temporal (ST) sequence-to-one deep learning architecture. This architecture makes full use of the ST information in multiple continuous image frames to detect the lane markings in the very last frame. Specifically, the hybrid model integrates the following aspects: (a) the single image feature extraction module equipped with the spatial convolutional neural network; (b) the ST feature integration module constructed by ST recurrent neural network; (c) the encoder–decoder structure, which makes this image segmentation problem work in an end-to-end supervised learning format. Extensive experiments reveal that the proposed model architecture can effectively handle challenging driving scenes and outperforms available state-of-the-art methods.
A stratification-based approach for handling conflicts in access control (2003)

In the health care sector, access to medical information is more and more electronically achieved. Therefore, it is very important to define security policies which restrict access to pieces of information in order to guarantee security properties like confidentiality or integrity properties. These security policies are not always free of conflicts, in particular in the presence of exceptional situations.This paper proposes tools for access control, based on the notion of roles, in the possibilistic logic framework. We first show how to formalize basic concepts of security policies. Then we present two approaches for dealing with conflicts based on a stratification of security policy's rules. Finally, an example of health care is presented.
Neutral Proteinases I and II of Aspergillus sojae (1972)

Some enzymatic properties of purified neutral proteinases I and II from Aspergillus sojae were investigated. Neutra_??_ proteinase I: The optimum pH for casein digestion was around 7 at 30°C for 10min and the optimum temperature was 55°C at pH 7.3 for 10min in the presence of Ca2-. The enzyme activity was almost completely lost at 55°C, pH 7.3, within 10min, but was stabilized by Ca2+ to some extent. At low temperature, the enzyme was highly stable at the range of pH 3 to 11, and at 49°C the most stable pH was 6 to 7. Neutral proteinase II: The optimum pH for casein digestion was around 6 at 30°C for 10min and the optimum temperature was 65°C at pH 7.3 for 10min. At low temperature, the enzyme was highly stable at the range of pH 4 to 11 and relatively stable at pH 1 to 2, but unstable at around pH 3. Though the enzyme was remarkably thermostable showing the remaining activity of ca. 80% even by the treatment at 99°C for 10min at pH 7.3, it was very unstable at 75°C. This unstability was considered to be resulted from the autolysis of the enzyme, which was conspicuously observed at pH 3 and pH 9. The presence of Ca2+ accelerated the inactivation of the enzyme. None of metallic salts tested promoted activities of the both enzymes, but Cu2+, Cd2-, Hg2-, Pb2+ and Sn4+ inhibited markedly neutral proteinase I even at low concentrations. EDTA, iodine and NBS inactivated the both enzymes, whereas sulfhydryl reagents, DFP and potato inhibitor did not affect their activities. Sodium thioglycolate, L-cysteine, KCN, 2-mercaptoethanol and phosphate ions inactivated neutral proteinase I to some extent, but did not neutral proteinase II.
La prueba en el delito de blanqueo de capitales: aspectos prácticos (1) (2009)

En las breves lineas que siguen se pretende dar resumida cuenta de las especiales dificultades que en la practica diaria, tanto de los organos jurisdiccionales de instruccion como de enjuiciamiento, se plantean a la hora de la obtencion de fuentes y luego de valoracion de la prueba incriminatoria esgrimida por las acusaciones en contra de los inculpados por el denominado delito de blanqueo de capitales, y como el recurso a la llamada prueba circunstancial o indiciaria resulta en casi todas las ocasiones imprescindible; trasladando al efecto los mas significados y recientes pronunciamientos jurisprudenciales de la Sala Segunda del Tribunal Supremo en dicha materia.
Ultrafast-laser inscription of a three dimensional fan-out device for multicore fiber coupling applications (2007)

A fan-out device has been fabricated using ultrafast-laser waveguide-inscription that enables each core of a multicore optical fiber (MCF) to be addressed by a single mode fiber held in a fiber V-groove array (FVA). By utilizing the unique three-dimensional fabrication capability of this technique we demonstrate coupling between an FVA consisting of a one-dimensional array of fibers and an MCF consisting of a two-dimensional array of cores. When coupled to all cores of the MCF simultaneously, the average insertion loss per core was 5.0 dB in the 1.55 mum spectral region. Furthermore, the fan-out exhibited low cross-talk and low polarization dependent loss.
Protein secondary structure prediction with a neural network. (1989)

A method is presented for protein secondary structure prediction based on a neural network. A training phase was used to teach the network to recognize the relation between secondary structure and amino acid sequences on a sample set of 48 proteins of known structure. On a separate test set of 14 proteins of known structure, the method achieved a maximum overall predictive accuracy of 63% for three states: helix, sheet, and coil. A numerical measure of helix and sheet tendency for each residue was obtained from the calculations. When predictions were filtered to include only the strongest 31% of predictions, the predictive accuracy rose to 79%.
Effectiveness of Information Technology Aided Relapse Prevention Programme in Schizophrenia excluding the effect of user adherence: A randomized controlled trial (2013)

The relapse prevention effectiveness of the ITAREPS was high, and we confirmed that the ITAREPS, i.e., detecting signs of relapse and increasing medication during the warning state, is an effective intervention during the early stages of relapse.
A multistep model for ovarian tumorigenesis: the value of mutation analysis in the <i>KRAS</i> and <i>BRAF</i> genes (2004)

Epithelial ovarian tumours represent a complex group of histological subtypes and there has long been controversy over the question of a precursor lesion for these neoplasms. The application of mutation analysis of the KRAS and BRAF genes (members of the RAS-RAF-MEK-ERK-MAP kinase pathway) is consistent with the model for progression of mucinous carcinomas and a subset of serous carcinomas (the so-called low-grade serous carcinomas) through benign and borderline lesions. The relatively high incidence of BRAF and KRAS mutations in serous borderline tumours and low-grade serous carcinomas, and their extremely low incidence/absence in high-grade serous carcinomas, provide strong evidence that high-grade carcinomas do not arise through this intermediate step.
Recruitment of Oct4 Protein to UV-Damaged Chromatin in Embryonic Stem Cells (2011)

Our studies demonstrate pluripotency-specific events that accompany DNA damage responses. Here, we discuss how ESCs might respond to DNA damage caused by genotoxic injury that might lead to unwanted genomic instability.
New Compounds. 5-Mercaptomethylfuroic Acid (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Compounds. 5-Mercaptomethylfuroic AcidFrank. Kipnis, Isidore. Levy, and John. OrnfeltCite this: J. Am. Chem. Soc. 1949, 71, 6, 2270–2271Publication Date (Print):June 1, 1949Publication History Published online25 October 2002Published inissue 1 June 1949https://pubs.acs.org/doi/10.1021/ja01174a600https://doi.org/10.1021/ja01174a600research-articleACS PublicationsRequest reuse permissionsArticle Views31Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Leaky surface-plasmon theory for dramatically enhanced transmission through a subwavelength aperture, Part I: Basic features (2004)

About three years ago, several groups in the physics community working collaboratively found experimentally a very interesting and initially puzzling effect. For a couple of years before that they had been studying a periodic array of sub wavelength holes in a metal plate at optical wavelengths. They reported that under the right conditions, transmission through the holes increased dramatically. More recently, they have been investigating the transmission through a single subwavelength-sized hole in a metal plate. When this tiny hole is made in a smooth metal plate, transmission through the hole was extremely small, as expected from small-aperture theory. Then, they found experimentally that when a periodic array of dimples or grooves is imposed on the initially smooth surface surrounding the hole the transmission of power through the hole is enhanced by "up to several orders of magnitude" (H.J. Lezec et al, PIERS 2002, p. 649, 2002). This astonishing increase in the transmission was difficult to believe at first, but measurements at optical frequencies were made at several laboratories and they have been reported in many papers. There is general agreement that surface plasmons (a class of surface waves) play a key role in this enhancement in transmission, but, to quote one recent paper (T. Thio, ibid., p. 648, 2002), "Although surface plasmons clearly play an important role in the transmission enhancement, the details of the enhancement mechanism are not yet understood." We believe that this interesting effect can be fully explained in terms of leaky waves, and we present here, in Part 1, the main features of the appropriate leaky-wave theory.
Differential effects of ethanol and the <i>rpsL1</i> (<i>strA1</i>) ribosomal mutation on the synthesis of an unusual protein coded by bacteriophages R17 and MS2 RNA (1981)

During translation of R17 and MS2 RNA, ethanol stimulates the synthesis of a coat-related protein which has identical electrophoretic mobility to that of polypeptide 7 studied by Atkins and his colleagues. Streptomycin stimulates the synthesis of this polypeptide and broadens the protein band. In contrast the ribosomal protein S12 mutation rpsL1 (strA1) has no detectable effect on its synthesis.
Human gingival proteases. I: Extraction and preliminary characterization of trypsin‐like and elastase‐like enzymes (1987)

In order to characterize neutral proteases in gingiva, tissue specimens from periodontitis patients were subjected to different extraction procedures. In addition to collagenase and gelatinase, serine proteases having trypsin‐like and elastase‐like properties were detected by utilizing synthetic aminoacid substrates. High salt concentration was required for the optimal extraction of these enzymes. They also needed a certain ionic strength for their activity. The pH optimum for the trypsin‐like activity was 7.5 and for the elastase‐like activity 8.0. A synthetic plasmin substrate was also degraded by the extracts but no activity against native fibrin was found. These neutral proteases may play a significant part in the extracellular protein degradation in periodontium during inflammation.
Phase I/II trial of continuous infusion vinorelbine for advanced breast cancer. (1994)

This trial, while confirming VRL activity in ABC, shows the feasability of a CIV administration schedule. A decrease of the administrated total dose per 3- to 4-week cycle to less than the weekly schedule with the same therapeutic activity suggests a better therapeutic index. The data are also suggestive of a dose-response relationship and a dose-intensity/activity correlation.
THE EFFECT OF FULLER'S EARTH ON PINENE AND OTHER TERPENES (1923)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE EFFECT OF FULLER'S EARTH ON PINENE AND OTHER TERPENESCharles S. VenableCite this: J. Am. Chem. Soc. 1923, 45, 3, 728–734Publication Date (Print):March 1, 1923Publication History Published online1 May 2002Published inissue 1 March 1923https://pubs.acs.org/doi/10.1021/ja01656a026https://doi.org/10.1021/ja01656a026research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prediction of the Solubility of Recovery Boiler Precipitator Ash (2009)

The solubility of recovery boiler precipitator ash in water is important in the design and operation of ash treatment systems used to control chloride (Cl) and potassium (K) accumulation in the kraft recovery cycle. We determined the solubility of mixtures of alkali salts that constitute precipitator ash and several precipitator ash sam-ples, through laboratory experiments and theoretical simulation using a commercially available thermodynamic pro- gram. The solubility of precipitator ash in water at 85°C varies widely, from 400–550 g/L H2O, depending on ash composition. The composition of the liquid portion of an ash-water slurry changes significantly with an increase in ash concentration: the Cl concentration increases, the sulfate (SO4) concentration decreases, and the K and carbon-ate (CO3) concentration remain the same. Between 30ºC–100ºC, temperature has little effect on the solubility of pre-cipitator ash and on the composition of the liquid portion of the slurry.
Query Languages for Bags (1993)

In this paper we study theoretical foundations for programming with bags. We fully determine the strength of many polynomial bag operators relative to an ambient query language. Then picking the strongest combination of these operators we obtain the yardstick nested bag query language NBL(monus, unique). The relationship between nested relational algebra and various fragments of NBL(monus, unique) is investigated. The precise amount of extra power that NBL(monus, unique) possesses over the nested relational algebra is determined. An ordering for dealing with partial information in bags is proposed and a technique for lifting a linear order at base types to linear order at all types is presented. This linear order is used to prove the conservative extension property for several bag languages. Using this property, we prove some inexpressibility results for NBL(monus, unique). In particular, it can not test for a property that is simultaneously infinite and co-infinite (for example, parity). Then non-polynomial primitives such as powerbag, structural recursion and bounded loop are studied. Structural recursion on bags is shown to be strictly more powerful than the powerbag primitive and it is equivalent to the bounded loop operator. Finally, we show that the numerical functions expressible in NBL(monus, unique) augmented by structural recursion are precisely the primitive recursive functions.