gebhart/patrepeval huggingface dataset:
Synthesis of a Flavin Receptor for Regulation of Ion Recognition by Assembling Components Necessary for a Binding Site (1995)

Absh.act -A flavin receptor with two 2,6-diacylaminopyridine moieties as the binding sites was synthesized.Upon complexation between the host and flavins bearing a polyether chain, the complex exhibits higher extractability toward K+ than the host or the guest alone.In host-guest chemistry, regulation of the binding ability has recently attracted much attention.Cooperativity, allosteryl and self-assembling2 have been employed for the regulation strategies in artificial recognition systems.In biological systems specific functions are sometimes induced by assembling several proteins with a protein called molecular chaperone which helps to constitute the assembled protein system but does not contribute the function directly.3This remote controlling methodology must be very important and efficient to regulate diverse functions of artificial molecules.In addition we think that this
Three-level three-phase neutral-point-clamped back-to-back converter applied to a wind emulator (2009)

This paper presents a three-level three-phase neutral-point-clamped back-to-back converter applied to a wind emulator, where a wind power generator is connected to the grid through the back-to-back converter. The converter regulates the power extracted from the generator and controls how this power is injected to the grid with the desired power factor. Two phase locked loops are in charge of synchronizing the generator-side and the grid-side converters, regardless of the rotor speed of the generator. DC-link neutral point voltage balance is performed by the modulation strategy of the back-to-back converter. Simulation and experimental results are provided to verify the correct performance of the system.
Congenital Muscular Dystrophy with Secondary Merosin Deficiency and Normal Brain MRI: A Novel Entity? (2000)

We describe two Scottish siblings affected by a form of congenital muscular dystrophy characterised by a severe clinical phenotype, similar to that observed in the 6q-linked merosin-deficient CMD but in whom brain MRI and cognitive development were normal. The maximal function achieved in the 2 siblings was sitting independently. Serum CK were grossly elevated and the skin and muscle biopsies showed a severe reduction of merosin in both. The normal brain MRI and normal cognitive development distinguish this form from Fukuyama congenital muscular dystrophy, muscle-eye-brain disease or other forms of CMD with secondary partial merosin deficiency and abnormal brain MRI and/or mental retardation. Linkage analysis excluded all the known loci for CMD. We propose that this may represent a novel variant of CMD.
A Novel MEMS Tunable Capacitor (2006)

A novel MEMS tunable capacitor with a high tuning ratio is presented in this paper. The novel tunable capacitor consists of two parallel electrodes, i.e., fixed and moving electrodes and six bi-directional electrostatic actuators, which are able to produce both attractive and repulsive force to drive the moving electrode. So the novel tunable capacitor is able to move in both directions, up and down, away form its static position and therefore achieve a large tuning ratio. Numerical simulations are used to verify the working principle of the novel tunable capacitor and predict that a tuning ratio of 3:1 can be achieved at a driving voltage of 16 volts.
Metal resistance in Candida biofilms (2006)

Yeasts are often successful in metal-polluted environments; therefore, the ability of biofilm and planktonic cell Candida tropicalis to endure metal toxicity was investigated. Fifteen water-soluble metal ions, chosen to represent groups 6A to 6B of the periodic table, were tested against this organism. With in vitro exposures as long as 24 h, biofilms were up to 65 times more tolerant to killing by metals than corresponding planktonic cultures. Of the most toxic heavy metals tested, only very high concentrations of Hg2+, CrO4 (2-) or Cu2+ killed surface-adherent Candida. Metal-chelator precipitates could be formed in biofilms following exposure to the heavy metals Cu2+ and Ni2+. This suggests that Candida biofilms may adsorb metal cations from their surroundings and that sequestration in the extracellular matrix may contribute to resistance. We concluded that biofilm formation may be a strategy for metal resistance and/or tolerance in yeasts.
Fully Homomorphic symmetric scheme without bootstrapping (2014)

Capability of operating over encrypted data makes Fully Homomorphic Encryption(FHE)the Holy Grail for secure data processing applications. Though many applications need only secret keys, FHE has not been achieved properly through symmetric cryptography. Major hurdle is the need to refresh noisy ciphertexts which essentially requires public key and bootstrapping. We introduce a refreshing procedure to make a somewhat homomorphic scheme, fully homomorphic without requiring bootstrapping. Our scheme uses symmetric keys and has performance superior to existing public-key schemes.
Accurate method for fast design of diagnostic oligonucleotide probe sets for DNA microarrays (2004)

We present a method for the automatic generation of oligonucleotide probe sets for DNA microarrays. This approach is well suited particularly for specificity evaluation of designed probes in large data sets. Algorithms for probe preselection, hybridization prediction and probe selection are presented. Combinatorial techniques are introduced for the selection of probe sets of high differentiation capability even from sequence databases of homologous conserved genes. These techniques include the automatic generation of group specific probes and the design of excluding probes. A basic prototype was implemented including a shared memory parallelization and distribution. The principal applicability of our method to a database of very conserved sequence data was shown and the run-time performance estimated.
FIB Fabrication of Metallic Nanostructures on End-faces of Cleaved Optical Fibers for Chemical Sensing Applications (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
An Adaptive Shared/Private NUCA Cache Partitioning Scheme for Chip Multiprocessors (2007)

The significant speed-gap between processor and memory and the limited chip memory bandwidth make last-level cache performance crucial for future chip multiprocessors. To use the capacity of shared last-level caches efficiently and to allow for a short access time, proposed non-uniform cache architectures (NUCAs) are organized into per-core partitions. If a core runs out of cache space, blocks are typically relocated to nearby partitions, thus managing the cache as a shared cache. This uncontrolled sharing of all resources may unfortunately result in pollution that degrades performance. We propose a novel non-uniform cache architecture in which the amount of cache space that can be shared among the cores is controlled dynamically. The adaptive scheme estimates, continuously, the effect of increasing/decreasing the shared partition size on the overall performance. We show that our scheme outperforms a private and shared cache organization as well as a hybrid NUCA organization in which blocks in a local partition can spill over to neighbor core partitions
北京最后的坟墓——法共《人道报》记者访《末代皇帝》影片意大利导演贝托卢奇 (1988)

两年的准备,抉择,加工剧本,6个月拍片。1986年8月14日,贝纳托·贝托卢奇在北京开始拍摄一部使他“最花功夫”的影片。他还要去天津、大连和长春。“如果说《末代皇帝》是部史诗般的电影,并不过分。”该片的意大利导演这样说。它也是,并且尤其是一个“道德与政治的故事”。它自由地汲取了爱新觉罗·溥仪自传中的内容。溥仪3岁的时候,即孙中山1911年建立中华民国的前几年,被慈禧太后扶上皇位。“这是在60多年中国历史的背景下,一个男人的生命历程。——从清朝的末代皇帝变成普通公民。”“这是我搞的最困难的一部影片”,贝托卢奇这样告诉我。他还许诺说电影将装点些“中国风采”。
Selective Templated Complexation of a Cylindrical Macrotricyclic Host with Neutral Guests:  Three Cation-Controlled Switchable Processes (2007)

A novel triptycene-based cylindrical macrotricyclic host 1 containing an anthracene unit and two dibenzo [24]crown-8 moieties was synthesized, and its cation binding properties were studied. It was found that the host could not only form complex with the paraquat derivative 4, but also show selective templated complexation with pyromellitic diimide 2 and anthraquinone 3 in the presence of lithium and potassium ions, respectively. Consequently, two novel cascade complexes with neutral molecules as bridging species were formed in solution and in the solid state, which were structurally studied by NMR, MS spectra, and X-ray methods. Moreover, we also found that the association and dissociation of the complexes could be easily achieved by the addition and removal of lithium or potassium ions, which resulted in three cation-controlled switchable processes.
Role and interaction of connective tissue growth factor with transforming growth factor-? in persistent fibrosis: A mouse fibrosis model (1999)

Skin fibrotic disorders are understood to develop under the influence of some growth factors, such as transforming growth factor-beta (TGF-beta), basic fibroblast growth factor (bFGF), or connective tissue growth factor (CTGF). To establish an appropriate animal model of skin fibrosis by exogenous application of growth factors, we investigated the in vivo effects of growth factors by injecting TGF-beta, CTGF, and bFGF into the subcutaneous tissue of newborn mice. A single application of TGF-beta or bFGF resulted in the formation of transient granulated tissue that disappeared despite 7 days of consecutive injections. A single CTGF injection also caused slight granulation. However, injecting TGF-beta plus CTGF produced long-term fibrotic tissue, which persisted for at least 14 days. Also, fibrotic tissue was observed when CTGF was injected from 4 to 7 days after TGF-beta injections for the first 1-3 days. In situ hybridization analysis revealed the expression of CTGF mRNA in the fibroblasts at least in a few fibrotic conditions. These findings suggest that either CTGF mRNA or an application of exogenous CTGF protein is required for the development of persistent fibrosis. From our study, it appears that interaction of several growth factors is required for persistent fibrotic tissue formation, with TGF-beta causing the induction and CTGF needed for maintenance of skin fibrosis. The animal model on skin fibrosis by exogenous application of growth factors developed in this study may prove useful for future studies on fibrotic disorders.
Investigations of thiol-modified phenol derivatives for the use in thiol–ene photopolymerizations (2014)

Thiol-ene photopolymerizations gain a growing interest in academic research. Coatings and dental restoratives are interesting applications for thiol-ene photopolymerizations due to their unique features. In most studies the relative flexible and hydrophilic ester derivative, namely pentaerythritoltetra(3-mercaptopropionate) (PETMP), is investigated as the thiol component. Thus, in the present study we are encouraged to investigate the performance of more hydrophobic ester-free thiol-modified bis- and trisphenol derivatives in thiol-ene photopolymerizations. For this, six different thiol-modified bis- and trisphenol derivatives exhibiting four to six thiol groups are synthesized via the radical addition of thioacetic acid to suitable allyl-modified precursors and subsequent hydrolysis. Compared to PETMP better flexural strength and modulus of elasticity are achievable in thiol-ene photopolymerizations employing 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione (TATATO) as the ene derivative. Especially, after storage in water, the flexural strength and modulus of elasticity is twice as high compared to the PETMP reference system.
Distal‐less and other homeobox genes in the development of the dentition (1994)

The mammalian tooth develops through an interaction between two tissue layers of different embryologic origin. A number of transcription factors and as well as two members of the Msx class of homeobox genes have been shown to be involved in the histogenesis of the mammalian tooth. This raised the possibility that other homeobox genes might be involved in dental morphogenesis. We have amplified mouse tooth germ cDNA from three different gestational ages by the polymerase chain reaction with degenerate primers for 18 classes of homeobox genes. Members of several classes have been isolated, including the Msx genes, two Dlx genes, and the Dbx, MHox, Mox2A genes. One of the Dlx genes, Dlx-7, had not previously been reported in mammals, and some details are presented of its cDNA sequence. This work plus that of other investigators has shown that at least six Dlx genes are expressed in developing teeth or in first branchial arches, suggesting the possibility that these genes are involved in specifying complexity within or between teeth. The screening approach with degenerate primers is a successful way to identify new as well as previously known regulatory genes expressed in developing tooth embryos.
4.6 kV, 10.5 mOhm×cm<sup>2</sup> Nickel Silicide Schottky Diodes on Commercial 4H-SiC Epitaxial Wafers (2010)

4H-SiC diodes with 0.60 mm2 nickel silicide Schottky contacts were fabricated on commercial epitaxial layers. At room temperature, the diodes have specific on-resistances (RON-SP) down to 10.5 mΩcm2 and blocking voltages (VBL) up to 4.6 kV, which is equal to 93 % of the calculated parallel plane breakdown voltage for used epitaxial structure. The corresponding figure-of-merit, defined as (VBL)2/RON-SP, is equal to 2015 MW/cm2 and is among the highest FOM values reported to date. The diodes demonstrated stable operation at forward current of 1 A and VBL value in excess of 3.3 kV at ambient temperatures up to 200 °C.
Mechanism of trace counterion transport through ion-exchange membranes (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of trace counterion transport through ion-exchange membranesWalter J. Blaedel, Theodore J. Haupert, and Merle A. EvensonCite this: Anal. Chem. 1969, 41, 4, 583–590Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://pubs.acs.org/doi/10.1021/ac60273a006https://doi.org/10.1021/ac60273a006research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deskwork support system based on the estimation of human intentions (2005)

We have proposed a system called an attentive workbench (AWB) that is designed to support desktop work. AWB is the system which estimates a worker's condition using some sensors and assists a worker using movable trays and projectors from both physical and informational viewpoints. A method for estimating an AWB user's intention is proposed and presented. An AWB user expresses his/her intention by pointing a finger at a necessary tray. For estimating which tray a user needs, the system uses dynamic Bayesian network to integrate the sensor data obtained from user's pointing gestures and user's past action sequences. A description of the experimental results are demonstrated the usefulness of the method proposed here.
ChemInform Abstract: PSYCHOACTIVE AGENTS: PART VIII. ISOTHIAZOLES: PART VIII. SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4‐(2‐AMINO‐4‐THIAZOLYL)ISOTHIAZOLES (1978)

Abstract Durch Kondensation von Thioharnstoffen [ wie z.B. den mit den Aminen (I) über die N‐tert.‐butyl‐Derivate (II) erhältlichen Thioharnstoffen (III)] mit den Isothiazolen (IV) dargestellte Thiazolylisothiazole, wie z.B. (V), sowie die ähnlich erhältlichen Iminothiazole (VI) werden auf ihre analgetische Aktivität hin getestet.
Retrofitting Large Refrigeration Systems with R-134a (1992)

This article discusses the major concerns during a conversion. It also provides a case study, in hopes of giving some practical insight into the process of retrofitting existing systems
The role of cholinergic agents in the management of behavioural disturbances in Alzheimer's disease (2000)

Alzheimer's disease (AD) is characterized by progressive cognitive deterioration, neuropsychological or behavioural disturbances, and eventual elementary neurological dysfunction. Changes in these domains lead to a reduced functional ability of the AD patient which results, inevitably, in an increasing dependency of the patient on their carer. Thus, a compromised quality of life for both the patient with AD and the carer ensues. The clinical deterioration in AD is produced by neurochemical deficits (involving cholinergic, noradrenergic and serotonergic systems) and histological changes (neuritic plaques, neurofibrillary tangles and neuronal death) in the brain. The abnormality in cholinergic neurotransmission, by contributing to both the cognitive impairment and possibly the behavioural disturbances of AD patients, has attracted particularly intense scientific attention. Evidence for the involvement of a cholinergic dimension to the behavioural changes of AD includes the following: the induction of AD-like behaviours in normal individuals by administration of anticholinergic drugs; the exaggeration of behavioural disturbances in AD patients by anticholinergic agents; the correlation of the distribution of cholinergic deficits of AD with regions that are relevant to the observed behaviours, i.e. the frontal and temporal regions; and the amelioration of behavioural disturbances in AD patients treated with cholinergic receptor agonists and cholinesterase inhibitors. This article reviews the increasing evidence that, in addition to their effects on the cognitive and functional domains of AD, cholinergic drugs may be considered psychotropic agents and are useful in the treatment of specific disorders with cholinergic deficits such as AD.
Pyrimidine phototetramer (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrimidine phototetramerShih Yi Wang and David F. RhoadesCite this: J. Am. Chem. Soc. 1971, 93, 10, 2554–2556Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/ja00739a044https://doi.org/10.1021/ja00739a044research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Disruption of a Single Allele of the Nerve Growth Factor Gene Results in Atrophy of Basal Forebrain Cholinergic Neurons and Memory Deficits (1997)

Administration of nerve growth factor (NGF) to aged or lesioned animals has been shown to reverse the atrophy of basal forebrain cholinergic neurons and ameliorate behavioral deficits. To examine the importance of endogenous NGF in the survival of basal forebrain cholinergic cells and in spatial memory, mice bearing a disruption mutation in one allele of the NGF gene were studied. Heterozygous mutant mice (ngf+/-) have reduced levels of NGF mRNA and protein within the hippocampus and were found to display significant deficits in memory acquisition and retention in the Morris water maze. The behavioral deficits observed in NGF-deficient mice were accompanied by both shrinkage and loss of septal cells expressing cholinergic markers and by a decrease in cholinergic innervation of the hippocampus. Infusions of NGF into the lateral ventricle of adult ngf+/- mice abolished the deficits on the water maze task. Prolonged exposure to NGF may be required to induce cognitive effects, because reversal of the acquisition deficit was seen after long (5 weeks) but not short (3 d) infusion. Although NGF administration did not result in any improvement in the number of septal cells labeled for choline acetyltransferase, this treatment did effectively correct the deficits in both size of cholinergic neurons and density of cholinergic innervation of the hippocampus. These findings demonstrate the importance of endogenous NGF for survival and function of basal forebrain cholinergic neurons and reveal that partial depletion of this trophic factor is associated with measurable deficits in learning and memory.
Structures and metrics for image storage and interchange (1993)

There are hundreds of different image file specifications in existence. A recent informal suivey recorded almost 100 formats in use by USENET readers alone. Thus, an imaging practitioner is faced with a large and sometimes bewildering range of image file standards to choose from, which, when coupled with the sparsity of studies in the area, makes acquiring a general overview of the field a difficult task. We seek to address this problem by reviewing the overall topic of image formats, describing the most notable standards, proposing a set of related metrics, and providing a source of further information.
Reductions in [ <sup>3</sup> H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease (1988)

In Alzheimer's disease (AD) and Parkinson's disease (PD), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. In the present study, we used receptor autoradiography to map the distribution of nicotinic [3H]acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects. In both diseases, a profound loss of nicotinic receptors occurs in all cortical layers, particularly the deepest layers.