gebhart/patrepeval huggingface dataset:
Intradermal Vaccination with Influenza Virus-Like Particles by Using Microneedles Induces Protection Superior to That with Intramuscular Immunization (2010)

Influenza virus-like particles (VLPs) are a promising cell culture-based vaccine, and the skin is considered an attractive immunization site. In this study, we examined the immunogenicity and protective efficacy of influenza VLPs (H1N1 A/PR/8/34) after skin vaccination using vaccine dried on solid microneedle arrays. Coating of microneedles with influenza VLPs using an unstabilized formulation was found to decrease hemagglutinin (HA) activity, whereas inclusion of trehalose disaccharide preserved the HA activity of influenza VLP vaccines after microneedles were coated. Microneedle vaccination of mice in the skin with a single dose of stabilized influenza VLPs induced 100% protection against challenge infection with a high lethal dose. In contrast, unstabilized influenza VLPs, as well as intramuscularly injected vaccines, provided inferior immunity and only partial protection (</=40%). The stabilized microneedle vaccination group showed IgG2a levels that were 1 order of magnitude higher than those of other groups and had the lowest lung viral titers after challenge. Also, levels of recall immune responses, including hemagglutination inhibition titers, neutralizing antibodies, and antibody-secreting plasma cells, were significantly higher after skin vaccination with stabilized formulations. Therefore, our results indicate that HA stabilization, combined with vaccination via the skin using a vaccine formulated as a solid microneedle patch, confers protection superior to that with intramuscular injection and enables potential dose-sparing effects which are reflected by pronounced increases in rapid recall immune responses against influenza virus.
Synthetic Inhibitors of Platelet Glycoprotein IIb/IIIa in Clinical Development (2000)

Activation of the platelet glycoprotein (GP IIb/IIIa) receptor on the platelet surface is the final pathway of platelet aggregation, regardless of the initiating stimulus. Inhibitors of GP IIb/IIIa receptors include monoclonal antibodies (abciximab) against this receptor and peptidic and nonpeptidic synthetic specific receptor blockers. Abciximab exchanges between and binds to platelets for as long as 2 weeks, whereas synthetic GP IIb/IIIa inhibitors inhibit ex vivo platelet aggregation for only a few hours after the end of infusion, but some have the advantage of also being orally active. In the secondary prevention of atherothrombosis, large-scale trials were successfully conducted with aspirin, dipyridamole, ticlopidine, and clopidogrel. In the first large-scale trials with GP IIb/IIIa inhibitors, abciximab was investigated. In aggregate, synthetic GP IIb/IIIa inhibitors, combined with aspirin and heparin, were shown to reduce ischemic events in patients with high- and low-risk coronary intervention, stents, unstable angina, and non-Q-wave infarction. With short-term use of synthetic GP IIb/IIIa inhibitors, there is no suppression of clinical evident restenosis 6 months after the end of treatment. With the doses currently used, bleeding occurs more often with the synthetic GP IIb/IIIa inhibitors (used for 3 days) than with abciximab (used for 12 hours), but there are no direct comparisons between these drugs.
Kinetics and mechanism of reversible, base-catalyzed ring closure of 3-(methoxycarbonyl)propionanilide and O-(methoxycarbonylmethyl)-N-phenylcarbamate (1989)

The rate constants of reversible, base-catalyzed ring closure of 3-(methoxycarbonyl)propionanilide ( I ) and O-(methoxycarbonylmethyl)-N-phenylcarbamate ( II ) to 1-phenyl-2,5-pyrrolidinedione ( III ) and 3-phenyl-2,4-oxazolidinedione ( IV ), respectively, and the rates of solvolyses of the cyclization products III and IV in water and methanol have been measured. In both cases, an equilibrium is established between the starting ester and the cyclization product in methoxide solutions which is strongly shifted in favour of the starting ester. In the case of ester II in methoxide solutions, the cyclization is followed by a much slower splitting of the cyclization product to give glycolic acid anilide. The effects of the group X = NH, CH 2 , O, S in the esters RNHCOXCH 2 .COOCH 3 on the rates of the cyclization and solvolysis of the cyclization products is discussed.
Prospects and Problems of Optical Diffuse Wireless Communication for Underwater Wireless Sensor Networks (2010)

The aim of this paper is to highlight the prospects and problems of optical wireless communication for applications in the field of Underwater Wireless Sensor Networks (UWSNs). The necessity of wireless underwater connections, especially in UWSN, has dramatically increased in the last few years for a wide range of applications, from environmental monitoring to surveillance. The problem of wireless underwater communication is a challenging field of investigation since common terrestrial devices, equipped with radio wireless links, cannot be employed underwater and current underwater available technologies, mainly based on acoustical solutions, still pose problems due to low propagation speed of sound in water and low data-rate. In the last years, the interest towards optical wireless communication has increased both for terrestrial (Akella et al., 2005) than for underwater applications (Doniec et al., 2010) since it allows to overcome some of the problems of acoustical communication (Akyildiz et al., 2005). In fact low data rate and low propagation speed require specific solutions and make it difficult the integration of underwater technologies with current available terrestrial modules. Transferring the paradigm of Smart Dust (V. Hsu & Pister, 1998) to UWSNs, largely unaffected byWSN revolution, is a challenge that can open great opportunities since current underwater solutions are still of large dimension, expensive and power-consuming.
Zonisamide reduces obstructive sleep apnoea: a randomised placebo-controlled study (2014)

Carbonic anhydrase inhibition reduces apnoeic events in sleep disordered breathing. Zonisamide inhibits carbonic anhydrase, and induces weight loss in obese patients. This study explored the relative influence of these two properties, which may both alleviate obstructive sleep apnoea (OSA). Continuous positive airway pressure (CPAP) was used as a standard care comparator. 47 patients with moderate-to-severe OSA and a body mass index of 27-35 kg·m(-2) were randomised to receive either zonisamide, placebo or CPAP for 4 weeks. The open extension phase (20 weeks) compared CPAP and zonisamide. Polysomnography, biochemistry and symptoms were evaluated. At 4 weeks, zonisamide reduced apnoea/hypopnoea index (AHI) by a mean±sd 33±39% and oxygen desaturation index by 28±31% (p=0.02 and 0.014, respectively; placebo adjusted). The mean compliance adjusted reduction of AHI after zonisamide and CPAP was 13 and 61%, respectively, (p=0.001) at 24 weeks. Body weight was marginally changed at 4 weeks, but reduced after zonisamide and increased after CPAP at 24 weeks (-2.7±3.0 kg versus 2.3±2.0 kg, p<0.001). Zonisamide decreased bicarbonate at 4 and 24 weeks. Side-effects were more common after zonisamide. Zonisamide reduced OSA independent of body weight potentially by mechanisms related to carbonic anhydrase inhibition. The effect was less pronounced than that obtained by CPAP.
The Design and Implementation of SYBASE Security Agent System (2006)

Now Sybase system has been widely used in China railway information system.To ensure information security of database,regarding the hidden trouble of safety in Sybase and TDS 5.0 protocol system,this paper studies and develops Sybase security agent system that is based on the application of network isolation technology.Based on discussing the design philosophy of agent system,the paper presents the system structure and the interchange process of information as well as the application of this system.
Assembly Requirements and Role of CotH during Spore Coat Formation in <i>Bacillus subtilis</i> (1999)

We report Western blot data showing that the 42.8-kDa product of the previously characterized cotH locus (8) is a structural component of the Bacillus subtilis spore coat. We show that the assembly of CotH requires both CotE and GerE. In agreement with these observations, the ultrastructural analysis of purified spores suggests that CotH is needed for proper formation of both inner and outer layers of the coat.
ISAC XXII International Congress (2004)

Abstract ISAC XXII International Congress (pages 27–73)
The Collision, Coalescence, and Disruption of Water Droplets (1968)

Using free pairs of droplets in the size range from 60 to 500 μ in radius, the effects of charge, velocity, and impact parameter on the collision and the disription of droplets have been examined. The impact parameters for collision and disruption of 300 and 60 μ radius droplets over a charge range from 10−15 to 10−12 C per droplet, and with impact velocity from 1 to 8 m/sec are reported. It is found that for droplets in this size and velocity range, electric charge on the droplets has no appreciable effect on the collision and coalescence process. However, the impact velocity and the impact parameter of the droplets dramatically affect the stability of the coalesced droplet. For 60 μ droplets, all collisions coalesce and form one droplet if the impact velocity is less than 2.2 m/sec. As the impact velocity is increased, the impact parameter for which only one droplet is produced after collision decreases and the all other collisions disrupt into several droplet fragments. For impact velocities greater than 8 m/sec, no collisions are stable.
Long-wavelength (λ≈16 μm), room-temperature, single-frequency quantum-cascade lasers based on a bound-to-continuum transition (2001)

Room-temperature operation of long-wavelength, Fabry–Perot and single-mode quantum-cascade lasers at λ≈16 μm is reported. Multimode emission with pulsed peak power up to 400 mW at −40 °C and 220 mW at 30 °C is demonstrated. Single-mode emission up to 60 mW peak power has been achieved at 30 °C.
Implementing a quantitative-based methodology for project risk assessment DSS (2008)

Project risk assessment is a critical activity adopted in project risk management process to prevent risks and to enhance the success rate of projects. But so far it is a big challenge for project managers and experts to combine their expertise with intelligent technology to evaluate project risks due to insufficient risk related data. Based on this, a novel attempt to integrate analytic hierarchy process (AHP) and support vector regression (SVR) is proposed to build the assessment decision model. A prototype system called project risk assessment decision support system (PRADSS) which consists of risk index system, AHP evaluation model, intelligent evaluation system, knowledge base and man-machine interaction is brought forward to reduce negative risk factors and assist in decision making. Software project risk assessment is conducted to show the efficiency and feasibility of the prototype system.
Raman Lidar (RL) Instrument Handbook (2011)

The Raman lidar at the ARM Climate Research Facility (ACRF) Southern Great Plains (SGP) Central Facility (SGPRL) is an active, ground-based laser remote sensing instrument that measures height and time resolved profiles of water vapor mixing ratio and several cloud- and aerosol-related quantities. The system is a non-commercial custom-built instrument developed by Sandia National Laboratories specifically for the ARM Program. It is fully computer automated, and will run unattended for many days following a brief (~5-minute) startup period. The self-contained system (requiring only external electrical power) is housed in a climate-controlled 8’x8’x20’ standard shipping container.
Regenerative Braking Control for High Level Deceleration on Low Mu Surface (2015)

<div class="section abstract"><div class="htmlview paragraph">Hybrid and electric vehicle (H/EV) technology is already well established in the automotive industry and a great majority of car manufacturers offer vehicles with alternative propulsion systems (hybrid or electric - H/E). This advancement, however, does not mean that all technical aspects of H/E propulsion systems have already been encapsulated or even fully understood. This statement is specifically valid for regenerative braking technology. In order to regenerate the maximum possible energy, which may be limited in real applications (e.g. by the charging ratio of the energy storage device(s)), the interaction of regenerative braking and the active driving safety systems (ADSSs) such as the anti-lock braking system (ABS) needs to be taken in to account. For maximum recaptured energy via electric motor (E-Motor) braking, the use of regenerative braking, which generates decelerations greater than 0.1g, should be deployed. This however, creates the possibility of ADSS intervention which limits the extensive use of regenerative braking for the full breath of the braking period.</div><div class="htmlview paragraph">In this paper, simulation results making use of a vehicle mathematical model are presented to highlight some important issues with regenerative braking control which are directly caused by the configuration of the driveline, namely one E-Motor fitted with an open differential. In the paper a regenerative braking controller based on slip control has been proposed to offer both a high level of restored energy and reduced braking distance, by maximizing on the traction for high deceleration braking maneuvers on a low mu surface.</div></div>
Pervasive Social Computing: Augmenting Five Facets of Human Intelligence (2010)

Pervasive Social Computing is a novel collective paradigm, derived from pervasive computing, social media, social networking, social signal processing, etc. This paper reviews Pervasive Social Computing as an integrated computing environment, which promises to augment five facets of human intelligence in physical environment awareness, behavior awareness, community awareness, interaction awareness, and content awareness. Reviews of related studies are given and their generic architectures are derived. The resulting architecture for Pervasive Social Computing is presented. A prototype is developed and examined in order to investigate the characteristics exhibited by Pervasive Social Computing.
Soft x-ray photoelectron spectroscopy study of the reaction of XeF2 with GaAs (1995)

The room temperature reaction of atomic F (via XeF2 vapor) with GaAs(110) wafers is studied employing synchrotron-based soft x-ray photoelectron spectroscopy. Both film growth and etching occur simultaneously in this reaction, as the GaAs substrate is consumed in forming a GaF3 film while the excess As is liberated. The intermediate reaction products GaF, AsF, and/or elemental As, as well as tricoordinate Ga and As atoms, are present at the GaF3–GaAs interface throughout the various stages of film growth.
Modeling of oxide breakdown from gate charging during resist ashing (1994)

Plasma damage was observed after exposing an antenna capacitor structure to an O/sub 2/ plasma in a single wafer resist asher. The observed early breakdown is well modeled by surface charging caused by plasma nonuniformity. Here, the plasma nonuniformity was induced by gas flow and electrode configuration. The present results agree well with our previous results where magnetic field leads to a nonuniform plasma. In this model, nonuniformity leads to a local imbalance of ion and electron currents which charge up the gate surface and degrade the gate oxide. Using SPICE, a circuit model for the test structure and plasma measurements, the Fowler-Nordheim current through the thin oxide regions at different points on the wafer was calculated and found to agree well with the observed damage. The important implication of this work on oxide reliability is that the modeling gives a clear picture to this breakdown mechanism. The charging model can also be applied to any ashing process in any nonuniform plasma. Moreover, this model provides a physical basis for design rules of device structures for the fabrication of reliable gate oxides in submicron MOS technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Determination of organic acids in foods by liquid chromatography (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of organic acids in foods by liquid chromatographyJames K. Palmer and Dieter M. ListCite this: J. Agric. Food Chem. 1973, 21, 5, 903–906Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/jf60189a019https://doi.org/10.1021/jf60189a019research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nonparametric roughness penalties for probability densities (1971)

Journal Article Nonparametric roughness penalties for probability densities Get access I. J. GOODD, I. J. GOODD Virginia Polytechnic Institute Search for other works by this author on: Oxford Academic Google Scholar R. A. GASKINS R. A. GASKINS Hampden-Sydney College Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 58, Issue 2, August 1971, Pages 255–277, https://doi.org/10.1093/biomet/58.2.255 Published: 01 August 1971 Article history Received: 01 November 1970 Revision received: 01 February 1971 Published: 01 August 1971
A +0.4°C accurate high-speed remote junction temperature sensor with digital Beta correction and series-resistance cancellation in 65nm CMOS (2013)

A true remote junction temperature sensor (RTS) with 3σ accuracy of 0.4 degrees over a temperature range of -40 to 130 degrees is presented. Using a novel digital beta compensation technique and series resistance cancellation (SRC), the sensor is capable of handling parasitic BJTs buried in other SoCs on a PCB located at large distances. The IC is manufactured in a 65nm digital CMOS process.
Computational medical imaging for total knee arthroplasty using visualitzation toolkit (2015)

This project is presented as a Master Thesis in the field of Civil Engineering, Biomedical specialization. As the
project of an Erasmus exchange student, this thesis has been under supervision both the Universite Livre de
Bruxelles and the Universitat Politecnica de Catalunya. The purpose of this thesis to put in practice all the
knowledges acquired during this Master in Industrial Engineering in UPC and to be a support for medical staff
in total knee arthoplasty procedures.
Prof. Emmanuel Thienpont has been working for years as orthopaedic surgeon at the Hospital Sant Luc,
Brussels. His years of work and research have been mainly focused on Total Knee Arthroplasty or TKA. During
one of the most important steps of this procedure, the orthopaedic surgeon has to cut the head of the femur
following two perpendicular cutting planes. Nevertheless, the orientation of these planes are directly dependant
of the femur constitution.
This Master Thesis has been conceived in order to offer the surgeon a tool to determine the proper direction
planes in a previous step before the surgical procedure. This project pretends to give the surgeon an openfree
computational platform to access to patient geometrical and physiological information before involving the
subject in any invasive procedure.
Developmental Regulation of the Cysteine-rich Outer-membrane Proteins of Murine Chlamydia trachomatis (1988)

The developmental cycle of the obligate intracellular prokaryote Chlamydia trachomatis involves the serial alternation of two distinct morphological forms of the organism. To examine the basis of chlamydial differentiation we have searched for developmentally regulated gene products in this species. Chlamydia-infected cells were pulse-labelled with [35S] cysteine at various stages of development and the products of synthesis examined by SDS-PAGE. Our results indicate that the synthesis of the cysteine-rich outer-membrane proteins is developmentally regulated, occurring only late in the cycle during the conversion of reticulate bodies to elementary bodies. Both hydroxyurea and ampicillin block this conversion; as a result of this blockade the cysteine-rich outer-membrane proteins are not produced in the presence of either drug.
The Production and Characterisation of Novel Conducting Redox‐Active Oligomeric Thin Films From Electrooxidised Indolo[3,2,1‐<i>jk</i>]carbazole (2009)

Indolo[3,2,1-jk]carbazole (IC) has been synthesised on a gram scale by flash vacuum pyrolysis. In contrast to a previous suggestion, IC is planar and it is also highly fluorescent, with a solution quantum yield of 0.41. Electro-oxidation of IC at a rotating disc electrode resulted in the passage of steady-state currents and the reproducible formation of conducting, redox-active films with constituent species that are also highly fluorescent. Unusually for coupled electroactive N-heterocyclic systems, electrochemical and spectroscopic characterisation revealed the film to consist exclusively of three redox-active (2,2', 5,5' and 2,5' coupled) IC dimers with no polymeric products. Calculations showed this coupling pattern to be consistent with IC radical-cation coupling through the accessible sites of highest unpaired electron density. The unusual combination of a high dimer second oxidation potential and a negligible dimer-dimer coupling rate explains the lack of further coupling. The identities of the dimeric species were confirmed by independent syntheses involving the Suzuki-Miyaura coupling of IC boronic acids as the key step. Electro-oxidation of the IC system therefore offers a ready route to novel conducting, redox-active molecular films and their redox-active, luminescent dimer constituents.
Glucose sensor based on an electrochemical reduced graphene oxide-poly(l-lysine) composite film modified GC electrode (2012)

A convenient and environmentally friendly method of fabricating glucose biosensors is proposed. Glucose oxidase (GOD) was immobilized on electrochemically reduced graphene oxide (ERGO) which was adsorbed on the poly-L-lysine (PLL) modified glassy carbon electrode after being immersed in GO solution for 4 h. The electrochemical behaviors of GOD/ERGO/PLL/GC electrode have been investigated by cyclic voltammetry. Direct electron transfer between GOD immobilized with ERGO/PLL and GC electrode was observed. Moreover, the GOD/ERGO/PLL/GC electrode exhibited excellent electrocatalytic activity for the detection of glucose with a linear range from 0.25 to 5 mmol L(-1).