gebhart/patrepeval huggingface dataset:
Feeding Tomato and Broccoli Powders Enriched with Bioactives Improves Bioactivity Markers in Rats (2009)

Many studies have evaluated the cancer -preventive potential of individual bioactives from tomatoes and broccoli, but few have examined them within the context of a whole food. Male Copenhagen rats were fed diets containing 10% standard tomato powder, tomato enriched with lycopene or total carotenoids, standard broccoli floret, broccoli sprouts, or broccoli enriched with indole glucosinolates or selenium for 7 days. All broccoli diets increased the activity of colon quinone reductase (NQO1). Indole glucosinolate-enriched broccoli and selenium-enriched broccoli increased hepatic NQO1 and cytochrome P450 1A activity (P < 0.05). Standard broccoli and lycopene-enriched tomato diets down-regulated prostatic glutathione S-transferase P1 mRNA expression. Different tomato diets resulted in altered hepatic accumulation of lycopene, phytofluene, and phytoene. These results demonstrate that the bioactive content of vegetables affects both tissue content of bioactives and activity of detoxification enzymes. Enhancing bioactive content of tomatoes and broccoli may enhance efficacy in the prevention of prostate cancer.
Heat Profiling of Three-Dimensionally Optically Trapped Gold Nanoparticles using Vesicle Cargo Release (2010)

Irradiated metallic nanoparticles hold great promise as heat transducers in photothermal applications such as drug delivery assays or photothermal therapy. We quantify the temperature increase of individual gold nanoparticles trapped in three dimensions near lipid vesicles exhibiting temperature sensitive permeability. The surface temperature can increase by hundreds of degrees Celsius even at moderate laser powers. Also, there are significant differences of the heat profiles in two-dimensional and three-dimensional trapping assays.
Detection of Monocyte Chemotactic and Activating Factor (MCAF) and Interleukin (IL)‐6 in Human Seminal Plasma and Effect of Leukospermia on These Cytokine Levels (1995)

These findings demonstrated the presence of MCAF and IL-6 in the seminal plasma, and that the levels of these cytokines were elevated in the seminal plasma of the infertile patients with leukospermia.
Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro (2011)

The development of immune cytopenias is a well-recognized side effect of many drugs. Quinine- and quinidine-dependent antibodies are classic examples of drug-induced effects that cause severe, life-threatening thrombocytopenia. Whereas the effects of drug-dependent antibodies on platelets have been well documented, their effects on megakaryocyte (Mk) biology are still unclear. We analyzed sera from several quinine-induced thrombocytopenia (QITP) patients on highly pure Mks (98% glycoprotein IIb-positive [GPIIb(+)]; 92% GPIX(+)) derived from human CD34(+) cells cultured with human thrombopoietin. We demonstrate by flow cytometry and confocal microscopy that QITP IgGs bind Mks efficiently in the presence of quinine. Incubation of day-4 Mks with QITP sera or purified IgG resulted in induction of apoptosis, a significant decrease in cell viability, and an increase in cell death. Furthermore, QITP sera preferentially reduced the number of late GPIX(+)/GPIbα(+) Mks and the number of receptors per cell in the surviving population. Ploidy distribution, lobularity, and average cell size of Mks remained unchanged after treatment. In addition, treated Mks showed a marked decrease in their proplatelet production capacity, suggesting that drug-dependent antibodies hinder platelet production. Therefore, QITP antibodies considerably reduce the proplatelet production capabilities of Mks despite undetectable effects on DNA content, morphology, and cell size.
Finance for Small and Medium‐sized Enterprises (1994)

Finance for longer‐term investment continues to be identified as a problem in the small and medium‐sized enterprise market. Recently the finance gap has been attributed to the use of capital gearing as a lending assessment technique. Income gearing, which would take account of the borrower′s expected future income flows may help to close the finance gap. Using a postal questionnaire and in‐depth interviews, information was gathered from companies about their forecasting procedures. The findings show that many companies have the necessary infrastructure to forecast income flows. However practice and culture need to change if lending based on income gearing is to become a reality. Company forecasts lack depth, and the time horizon chosen is too short especially in relation to capital expenditure budgets. In the small and medium sector the relationship between budgets and strategic planning is not yet understood.
Purification and characterization of a unique human interleukin 1 from the tumor cell line U937. (1986)

Interleukin 1 (IL 1) produced by a human tumor cell line was purified to homogeneity by a three-step chromatographic method and was tested in various assays for multiple biologic properties. The purified IL 1 stimulated the proliferative response of the D10.G4.1 cell line, a mouse IL 1 indicator T cell; caused the release of prostaglandin E2 and prostacyclin from cultured human foreskin fibroblasts and from primary human umbilical vein endothelial cells; and elicited characteristic endogenous pyrogen fever in rabbits. To stimulate IL 1 production, the histiocytic lymphoma cell line U937 was incubated with the exotoxin from toxic shock strains of Staphylococcus aureus. Supernatants from stimulated U937 cells were concentrated, and were applied to a reverse-phase HPLC column. IL 1 activity was eluted from the column at high acetonitrile concentration. Subsequent chromatography over hydroxyapatite yielded a single IL 1 species with a pI of 5.5. IL 1 was then purified to homogeneity by gel exclusion HPLC migrating as a 14 kDa species. The molecular size was confirmed by SDS-PAGE and was visualized as a single molecule by silver staining; biologic activity was recovered from the same region of the gel. Limited N-terminal sequence analysis suggested some homology to the pI 7 form of the human blood monocyte IL 1. The pI 5.5 IL 1 produced by U937 cells was only partially neutralized with anti-human monocyte IL 1 antibody, suggesting that U937-derived IL 1 is structurally related to one of the molecularly cloned IL 1 species. IL 1 from stimulated U937 cells possesses the functional characteristics of monocyte IL 1 but may represent a structurally unique IL 1 species, as determined by sequence analysis, size, and antibody reactivity.
SITUACIÓN ACTUAL DE LA CONSERVACIÓN DE LA FLORA CANARIA (2015)

SITUACIÓN ACTUAL DE LA CONSERVACIÓN DE LA FLORA CANARIA
Sap beetles and mycotoxins in maize (1995)

Sap beetles (Coleoptera: Nitidulidae) are important in vectoring mycotoxigenic species of Aspergillus and Fusarium to maize. Species examined are attracted to fungal and maize volatiles, and are resistant to most mycotoxins compared to maize ear-infesting caterpillars. They will invade ears damaged by birds or caterpillars or those ears that have poor husk coverage. An integrated control programme for these insects under development presently includes pheromones and host coattractants for trapping; identification and dispersal of pathogenic nematodes and fungi; identification of maize varieties cross-resistant to mycotoxigenic fungi and other insects, and the potential mechanisms involved; and formulations of insecticides for single treatment, low active ingredient, selective control of insect pests of ears including sap beetles and caterpillars that preserve naturally occurring predators and parasites. Autoinoculative devices are also being tested to use sap beetles to deliver biocompetitors of mycotoxigenic fungi to maize.
Adaptive feedback technique for unmodeled disturbance rejection (1995)

This work presents experimental results of a hybrid control technique that blends traditional fixed feedback control with adaptive feedback techniques. The objective is to provide damping for transient disturbances via the fixed controller and rejection of steady disturbances via the adaptive controller. This technique differs from other control techniques in that it does not require a measurement of an external signal coherent with the disturbance, nor does it require knowledge of how the disturbance enters the system. As with all feedback techniques, stability is an issue. The adaptive controller is implemented to minimize stability problems and in the case of perfect system identification, it is guaranteed stability. The experimental results are from a cantilever beam with piezoceramic actuators and sensors. The fixed feedback controller results are compared to the adaptive feedback control results. The comparison will include results from disturbances resulting from a single harmonic, narrowband signal, and broadband signal.
The Year Book of Pathology and Clinical Pathology (1959-1960 Year Book Series) (1961)

This book continues the fine tradition of summarizing the important publications of the past year that relate to pathology. The editorial comments of the author, as usual, help place the contributions of these papers into proper perspective. After reading this book, one has the feeling that few new techniques are described, and few new areas of interest have been opened up during the past year. The single special article by Dr. Robert Schrek, entitled<i>Fashions in Cancer Research</i>, is an interesting analysis of the trends in cancer research over the years. He explores the controversy over the role of experimental tumors, the furor over genetic or environmental factors in experimental cancers, and the current interest in viral etiology of neoplasia. The possible effects of these fashions in research on the outcome of the quest for solution to the "cancer problems" are considered.
Influence of molecular weight on selective oligomer-assisted dispersion of single-walled carbon nanotubes and subsequent polymer exchange (2012)

A series of oligofluorenes was synthesized and used as a SWNT selecting template to study the chain length effect on SWNTs dispersions in toluene. The octamer exhibits the same selectivity as the corresponding polymer. Nevertheless, SWNT/oligomer complexes are unstable, which allows fast exchange of the oligomer with a coating polymer.
AN IMPROVED SYNTHESIS OF<i>N</i>-BOC PROTECTED ARYL AMINES (2001)

There are several known methods of protecting amines as their Boc derivatives. For less nucleophilic amines such as aryl amines these methods often give poor yields and are generally not satisfactory. Here, Boc aryl amines are obtained by first introducing two Boc groups followed by selective removal of one of them. This procedure works well for a number highly sterically hindered substrates as well as electron deficient and electron rich aryl amines.
Carboxylato-triphenylphosphine complexes of ruthenium, cationic triphenylphosphine complexes derived from them, and their behaviour as homogeneous hydrogenation catalysts for alkenes (1973)

The two-electron reduction of the oxo-centred triangular acetato-complex, Ru3O(CO2Me)6(PPh3)3, in which the metal has mean oxidation state 2⅔, gives a yellow ruthenium(II) species, probably Ru(CO2Me)2PPh3. In methanol containing a non-complexing strong acid and additional triphenylphosphine to give a minimum PPh3 : Ru ratio of 2 : 1, the complex acts as a catalyst for the hydrogenation of alkenes. Similar catalyst solutions in methanol are obtained by the action of acids on the hydrido-acetate, RuH(CO2Me)(PPh3)3, or the dihydride, Ru(H)2(PPh3)4; aqueous fluoroboric acid, p-toluenesulphonic acid hydrate or trifluoromethylsulphonic acid have been used. The initial product is evidently the (solvated) cation [Ru(PPh3)3]2+, but in presence of alkene a bis species, such as [Ru(PPh3)2(alkene)]2+ is formed. On standing, or on treatment with H2 or CO in absence of alkene, the orange-red tris species are converted to catalytically inactive yellow species, this reaction being faster in presence of water. From aged solutions the salt [(Ph3P)2Ru(OH)2Ru(PPh3)2](BF4)2 has been isolated. The yellow solutions of Ru(CO2Me)2PPh3 are oxidised by air to a new type of oxo-bridged ruthenium(III) complex, Ru2O(CO2Me)4(PPh3)2, which is shown to be an intermediate in the preparation of RuH(CO2Me)(PPh3)3 from commercial hydrated ruthenium chloride. The diacetate, Ru(CO2Me)2(PPh3)2 has also been prepared and the reduction of the tetra-µ-acetato-complex [Ru2(CO2Me)4]Cl investigated. Analogues of some of the compounds with other carboxylate groups are described.
Automatic registration of mobile LiDAR and spherical panoramas (2012)

We present an automatic mutual information (MI) registration method for mobile LiDAR and panoramas collected from a driving vehicle. The suitability of MI for registration of aerial LiDAR and aerial oblique images has been demonstrated in [17], under an assumption that minimization of joint entropy (JE) is a sufficient approximation of maximization of MI. In this paper, we show that this assumption is invalid for the ground-level data. The entropy of a LiDAR image can not be regarded as approximately constant for small perturbations. Instead of minimizing the JE, we directly maximize MI to estimate corrections of camera poses. Our method automatically registers mobile LiDAR with spherical panoramas over an approximate 4 kilometer drive, and is the first example we are aware of that tests mutual information registration in large-scale context.
Endogenous serotonin and serotonin<sub>2C</sub>receptors are involved in the ability of M100907 to suppress cortical glutamate release induced by NMDA receptor blockade (2008)

Blockade of NMDA receptors by intracortical infusion of 3-(R)-2-carboxypiperazin-4-propyl-1-phosphonic acid (CPP) increases glutamate (GLU) and serotonin (5-HT) release in the medial prefrontal cortex and impairs attentional performance in the 5-choice serial reaction time task. These effects are prevented by the 5-HT(2A) receptor antagonist, (R)-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol (M100907). We explored the roles of endogenous 5-HT and 5-HT(1A) and 5-HT(2C) receptors in the mechanisms by which M100907 suppresses CPP-induced release of cortical GLU and 5-HT using in vivo microdialysis. CPP raised extracellular GLU and 5-HT by about 250% and 170% respectively. The 5-HT synthesis inhibitor, p-chlorophenylalanine (300 mg/kg), prevented M100907 suppressing CPP-induced GLU release. The effect of M100907 on these rises of GLU and 5-HT and attentional performance deficit was mimicked by the 5-HT(2C) receptor agonist, (S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine fumarate, (Ro60-0175, 30 microg/kg) while intra-mPFC (SB242084, 6-chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline, 0.1 microM), a 5-HT(2C) receptor antagonist, prevented the effect of M100907 on extracellular GLU. The 5-HT(1A) receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexane carboxenide trihydrochloride (100 microM) abolished the effect of M100907 on the CPP-induced 5-HT release. The data show that blockade of 5-HT(2A) receptors is not sufficient to suppress the CPP-induced rise of extracellular GLU and 5-HT and suggest that M100907 suppresses GLU release induced by CPP by enhancing the action of endogenous 5-HT on 5-HT(2C) receptors.
Reading order independent grouping proof for RFID tags (2008)

Using RFID to verify the simultaneous presence of more than one tag has generated interest since the Yoking Proof mechanism was proposed by A. Jues [5]. Various protocols [6], [7], [9] have been proposed ever since. However, all these protocols require that the tags are ordered in a certain way. This article proposes an order-independent protocol which improves the efficiency and reduced failure rates. Privacy is also protected by not sending the identity in plain text.
A novel compact monolithic active regulated self-biased InP HEMT amplifier (1994)

This letter reports on the first results of a monolithic active regulated self-biased HEMT amplifier fabricated in InP technology. The self-bias scheme incorporates an op-amp-based HEMT regulator topology that regulates the bias current to within 6% over a threshold variation of /spl plusmn/0.2 V. The DC yield based on this performance criteria was 75% across a wafer. The InP HEMT amplifier achieves an RF gain of 10-dB and a 3-dB bandwidth of 1-14 GHz. Across a wafer with a total threshold variation of 0.4 V, the gain variation was maintained to less than /spl plusmn/1 db. The compact integrated HEMT regulated amplifier circuit was realized using area-efficient analog design techniques that consumed less than 1.3/spl times/1.1 mm/sup 2/. This demonstration has far-reaching implications to the producibility and reliability of InP HEMT MMIC's.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Isolation of Two Plaque Variants from the Adenovirus Type 2-Simian Virus 40 Hybrid Population Which Differ in Their Efficiency in Yielding Simian Virus 40 (1970)

Studies on the adenovirus type 2-simian virus 40 (SV40) hybrid population demonstrated two genetically stable variants within this population, which were isolated by plaquing in African green monkey kidney cells. These variants were similar in that each induced SV40 T antigen in human embryonic kidney cells and contained similar concentrations of nonhybrid adenovirus type 2 virions and adenovirus-encapsidated particles containing the infectious SV40 genome. These variants differed markedly, however, in their ability to produce SV40 viral antigen in human embryonic kidney cells and the efficiency with which they produce SV40 plaques in monkey cell monolayers. It is postulated that the differences in SV40-yielding efficiency between these variants lie in the nature of the recombinant deoxyribonucleic acid composing the genome of the hybrid particles.
Scalable consistency protocols for distributed services (1999)

A common way to address scalability requirements of distributed services is to employ server replication and client caching of objects that encapsulate the service state. The performance of such a system could depend very much on the protocol implemented by the system to maintain consistency among object copies. We explore scalable consistency protocols that never require synchronization and communication between all nodes that have copies of related objects. We achieve this by developing a novel approach called local consistency (LC). LC based protocols can provide increased flexibility and efficiency by allowing nodes control over how and when they become aware of updates to cached objects. We develop two protocols for implementing strong consistency using this approach and demonstrate that they scale better than a traditional invalidation based consistency protocol along the system load and geographic distribution dimensions of scale.
The effect of second antibody clearance on the distribution and dosimetry of radiolabelled anti‐cea antibody in a human colonic tumor xenograft model (1989)

Radioimmunotherapy in humans is limited by toxicity to normal tissues, caused by circulating radio-antibody. Second antibody directed against the first (anti-tumor) antibody accelerates clearance of first antibody from normal tissues, and may thus improve the therapeutic ratio. The effect of second antibody both on anti-tumor antibody distribution and on tumor and normal tissue radiation doses, has been investigated in nude mice bearing colonic tumor xenografts. Second antibody, given either 6 or 24 hr after the first, rapidly cleared circulating activity and reduced the calculated radiation dose to all tissues except the spleen, where it rose by 11 and 43% respectively. The dose received by the blood fell by 87% and 71%, while that to the tumor was reduced by 81% and 58%, after 6 or 24 hr second antibody. Administration of second antibody therefore improved the tumor to blood ratios. Tumor identification by gamma camera was greatly facilitated by the use of second antibody, and required no background subtraction. Results obtained from this system demonstrate the utility of second antibody in protecting normal tissues from prolonged circulating radioactivity during radioimmunotherapy.
A Stream Habitat Classification System for Beaver (1985)

On developpe et l'on teste deux modeles permettant de predire la densite maximum des colonies actives de Castor canadensis dans les cours d'eau (documentation portant sur 28 ans, dans le Massachusetts) et de classer les habitats
Regulatory Regions in DNA: Promoters, Enhancers, Silencers, and Insulators (2010)

One of the mechanisms through which protein levels in the cell are controlled is through transcriptional regulation. Certain regions, called cis-regulatory elements, on the DNA are footprints for the trans-acting proteins involved in transcription, either for the positioning of the basic transcriptional machinery or for the regulation - in simple terms turn on or turn off - thereof. The basic transcriptional machinery is DNA-dependent RNA polymerase (RNAP) which synthesizes various types of RNA and core promoters on the DNA are used to position the RNAP. Other nearby regions will regulate the transcription: in prokaryotic organisms operators are involved; in eukaryotic organisms, proximal promoter regions, enhancers, silencers, and insulators are present. This chapter will describe the various DNA regions involved in transcription and transcriptional regulation.
Flutter in flow-limited collapsible tubes: a mechanism for generation of wheezes (1989)

We studied flutter in collapsible tubes as a possible mechanism for the generation of respiratory wheezes. The pressure-flow relationships and the wall oscillations of thick-walled [wall thickness (h)-to-lumen radius (r) ratio 1:1.7 to 1.3] self-supporting latex and Silastic tubes mounted between rigid pipes were measured. A high-impedance vacuum pump was connected to the downstream end. Upstream and downstream valves were used to control corresponding resistances. We found loud honking sounds and tube wall oscillations that occurred only when the tubes were buckled and flow limiting, i.e., when the flow became constant and independent of downstream driving pressure. The overall range of oscillatory frequencies was 260-750 Hz for airflow, presenting as sharp peaks of power on the frequency spectrum. The oscillatory frequencies (f) were higher at higher fluid velocities (u) and with narrower distance between opposing flattened walls (2b), resulting from increasing downstream suction pressure and the transmural pressure becoming more negative. The effect of u and b on f for a latex tube (h-to-r ratio 1:1.7) were found to be f = 228 + 0.021 (u/b). These relationships were valid throughout the range of oscillations in this tube (283-720 Hz) and with flow rates of 12-64 l/min. The experimental data were compared with predictions of the fluid dynamic flutter theory and the vortex-induced wall vibrations mechanism. We conclude that viscid flutter in soft tubes is the more probable mechanism for the generation of oscillations in the soft tube model and is a possible mechanism for the generation of respiratory wheezes.