gebhart/patrepeval huggingface dataset:
Self-Adaptive Step Counting on Smartphones under Unrestricted Stepping Modes (2016)

Pedometer apps on smartphones and wearable electronics are increasingly popular nowadays, as they are widely used for health monitoring and location-based systems. Most pedometer apps are based on inertial sensors and each step counting algorithm works precisely under restricted stepping modes because steps are detected and validated after comparing their parameters to pre-determined optimal values related to particular conditions. In this paper, we propose self-adaptive step counting in order to improve step counting accuracy under unrestricted stepping modes on smartphones. Based on our human stepping model, we propose self-adaptive method that can detect new steps by monitoring vertical acceleration and validate new steps by comparing to self-adaptive values, which are adjusted dynamically after each step occurs. We show the flexibility of the proposed approach by incorporating it into two existing step counting algorithms WPD and DTW. We also propose a new stepping cycle recognition (SCR) algorithm that is self-adaptive and performs the best under variant stepping modes. With experiments under different stepping modes including fixed and variant modes, we show that self-adaptive methods perform significantly better compared to original methods using fixed optimal values.
8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells. (1997)

TMB is an effective agent for blocking the [Ca2+]i increase caused by NE and BHQ and for enhancing the [Ca2+]i reduction caused by ryanodine.
The Human Component (2021)

This contribution is written from the perspective of a trial attorney with more than 20 years of experience representing clients in the California criminal justice system. Proper representation of the accused often requires a multidisciplinary approach in which legal care, medical care and mental health care work in conjunction with one another. Often, a client is laboring through layers of physical pain, fear, grief, and a possible myriad of mental health issues when his or her liberty is dependent on the ability to provide an accurate picture of their lives. In order to assist the client in providing the most comprehensive description of himself or herself, the defense team requires an empathic approach; one that is respectful of boundaries; and one willing to explore the context of the information uncovered during the course of investigation and representation. This contribution will detail the case of Marissa B , and how her investigation and advocacy wed her data to the context and circumstances surrounding her case to reveal information behind the human being in need of representation.
The effects of processing on the mechanical properties of a polyolefin blend (1992)

Abstract The procedure employed to prepare blends plays a significant role on the ultimate morphological and mechanical properties of the blend. This was demonstrated through the use of a styrene‐ethylene/butylene‐styrene (SEBS) triblock copolymer as a compatibilizer for isotactic polypropylene and linear lowdensity polyethylene. The considerable increases in impact strength for the blends containing the higher percentages of SEBS are related to the magnitude of plastic deformation observed in the matrix and to the size of the occlusions.
Enhanced Efficacy of Melanoma Vaccines in the Absence of B Lymphocytes (2004)

Provoking a specific cellular immune response against tumor-associated antigens is a promising therapeutic strategy to treat cancers with defined antigens such as melanoma. In recent clinical trials, however, immune responses against melanoma antigens have been elicited without consistent clinical responses, suggesting the need for approaches that potentiate the specific cellular immune response. Since B lymphocytes have been reported to exert a negative effect on the cellular arm of the immune response in certain model systems, the authors compared the protective immunity elicited by melanoma antigens in B cell-deficient microMT mice to that obtained in fully immunocompetent C57BL/6 mice. Immunization with melanoma-associated antigens was accomplished using recombinant adenovirus (Ad) vectors encoding human gp100 (Ad2/gp100) or murine TRP-2 (Ad2/mTRP-2). A single dose of Ad2/gp100 or Ad2/mTRP-2 inhibited the growth of established subcutaneous B16 melanoma tumors in B cell-deficient but not wild-type C57BL/6 mice. The enhanced tumor protection observed in B cell-deficient mice appeared to be associated with potentiation of the magnitude and longevity of the specific cellular immune response. Natural killer (NK) cells were also found to be essential to the protective immune response in microMT mice because NK cell depletion with anti-asialo-GM1 antibody resulted in both the loss of tumor growth suppression and attenuation of the specific cellular immune response. The authors conclude that the protective cell-mediated immunity provoked by Ad-based cancer vaccines is enhanced in the absence of B cells, suggesting that a therapeutic regimen that includes depletion of B lymphocytes may be beneficial to cancer vaccine therapy.
Engineering nitrogen use efficiency in Oryza sativa by the developmental over-expression of barley alanine aminotransferase using a novel rice promoter (2011)

Nitrogen is the main limiting component to plant growth and development. With increasing cost of food production the development of nitrogen use efficient (NUE) crop plants has become of interest. In our group, the over-expression of barley alanine aminotransferase (HvAlaAT) cDNA by the btg26 and OsANT1 promoters has yielded NUE plants. Through a detailed bioinformatic analysis, the PBpr1 promoter was selected, cloned, and coupled to HvAlaAT for over-expression in rice (Oryza sativa cv. Nipponbare). Overall, rice lines carrying PBpr1::HvAlaAT resulted in higher seed yield, biomass and tillering compared to non-transformed Nipponbare. Molecular analysis of these lines showed high levels of HvAlaAT mRNA and alanine aminotransferase (AlaAT) protein. Transgenic shoots exhibits high levels of AlaAT activity at all times while root activity increased only after active tillering, indicating developmental regulation of the gene in roots. Analysis of PBpr1 pattern expression, however, showed no definitive staining despite the observed over-expression of HvAlaAT at the transcript and enzyme activity level.
Synthesis of SiC/BN nanocomposite powders by carbothermal reduction and nitridation of borosilicate glass, and the properties of their sintered composites (2008)

A new synthetic method for the fabrication of SiC/BN nanocomposites was devised to attain strong machinable ceramics. SiC/BN nanocomposites that contained 10, 20, and 30 vol% hexagonal BN (h-BN) were successfully fabricated by sintering SiC-BN nanocomposite powders by carbothermal reduction and nitridation of borosilicate glass powders. Homogeneous mixtures of silica (SiO(2)), boric acid (H(3)BO(3)), and carbon powder were heated in a nitrogen atmosphere to synthesize SiC-BN nanocomposite powders. Borosilicate glass was obtained by reacting SiO(2) and B(2)O(3) above 800 °C, and SiC and turbostratic BN (t-BN) were obtained by reacting borosilicate glass with carbon powder and nitrogen gas at 1500 °C. Carbothermal reduction followed by nitridation yielded SiC-BN nanocomposite powder composed of nanosized SiC and t-BN. By hot-pressing nanocomposite SiC-BN powders containing 7 wt% Al(2)O(3) and 2 wt% Y(2)O(3), machinable SiC/BN nanocomposites were obtained without a significant decrease in their fracture strength.
Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer (2019)

The identified biomarkers underwent experimental testing on an independent set of blood samples from patients with colorectal cancer. As a result, using advanced methods of statistics and machine learning, a minimum set of 6 biomarkers was selected, which together achieve the best cancer detection potential. The markers include hypermethylated positions in regulatory regions of the following genes: CALCA, ENO1, MYC, PDX1, TCF7, ZNF43.
The binding of sodium dodecyl sulphate to various proteins (1968)

1. The binding of sodium dodecyl sulphate to proteins by equilibrium dialysis was investigated. 2. Most of the proteins studied bound 90-100% of their weight of sodium dodecyl sulphate. 3. The glycoproteins studied bound 70-100% of their weight of sodium dodecyl sulphate, calculated in terms of the polypeptide moiety of the molecule. 4. Proteins not containing S.S groups bound about 140% of their weight of sodium dodecyl sulphate. 5. Reduction of four proteins containing S.S groups caused a rise in sodium dodecyl sulphate binding to 140% of the weight of protein. 6. The apparent micellar molecular weights of the protein-sodium dodecyl sulphate complexes were measured by the dye-solubilization method; they were all found to have approximately the same micellar molecular weight (34000-41000) irrespective of the molecular weight of the protein to which they were attached.
Two‐Dimensional X‐Ray Diffraction (2009)

Preface. 1. Introduction. 1.1 X-Ray Technology and Its Brief History. 1.2 Geometry of Crystals. 1.3 Principles of X-Ray Diffraction. 1.4 Reciprocal Space and Diffraction. 1.5 Two-Dimensional X-Ray Diffraction. 2. Geometry Conventions. 2.1 Introduction. 2.2 Diffraction Space and Laboratory Coordinates. 2.3 Detector Space and Detector Geometry. 2.4 Sample Space and Goniometer Geometry. 2.5 Transformation from Diffraction Space to Sample Space. 2.6 Summary of XRD2 Geometry. References. 3. X-Ray Source and Optics. 3.1 X-Ray Generation and Characteristics. 3.2 X-Ray Optics. References. 4. X-Ray Detectors. 4.1 History of X-Ray Detection Technology. 4.2 Point Detectors in Conventional Diffractometers. 4.3 Characteristics of Point Detectors. 4.4 Line Detectors. 4.5 Characteristics of Area Detectors. 4.6 Types of Area Detectors. 5. Goniometer and Sample Stages. 5.1 Goniometer and Sample Position. 5.2 Goniometer Accuracy. 5.3 Sample Alignment and Visualization Systems. 5.4 Environment Stages. References. 6. Data Treatment. 6.1 Introduction. 6.2 Nonuniform Response Correction. 6.3 Spatial Correction. 6.4 Detector Position Accuracy and Calibration. 6.5 Frame Integration. 6.6 Lorentz, Polarization, and Absorption Corrections. 7. Phase Identification. 7.1 Introduction. 7.2 Relative Intensity. 7.3 Geometry and Resolution. 7.4 Sampling Statistics. 7.5 Preferred Orientation Effect. References. 8. Texture Analysis. 8.1 Introduction. 8.2 Pole Density and Pole Figure. 8.3 Fundamental Equations. 8.4 Data Collection Strategy. 8.5 Texture Data Process. 8.6 Orientation Distribution Function. 8.7 Fiber Texture. 8.8 Other Advantages of XRD2 for Texture. References. 9. Stress Measurement. 9.1 Introduction. 9.2 Principle of X-Ray Stress Analysis. 9.3 Theory of Stress Analysis with XRD2. 9.4 Process of Stress Measurement with XRD2. 9.5 Experimental Examples. Appendix 9.A Calculation of Principal Stresses from the General Stress Tensor. Appendix 9.B Parameters for Stress Measurement. References. 10. Small-Angle X-Ray Scattering. 10.1 Introduction. 10.2 2D SAXS Systems. 10.3 Application Examples. 10.4 Some Innovations in 2D SAXS. References. 11. Combinatorial Screening. 11.1 Introduction. 11.2 XRD2 Systems for Combinatorial Screening. 11.3 Combined Screening with XRD2 and Raman. 12. Quantitative Analysis. 12.1 Percent Crystallinity. 12.2 Crystal Size. 12.3 Retained Austenite. References. 13. Innovation and Future Development. 13.1 Introduction. 13.2 Scanning Line Detector for XRD2. 13.3 Three-Dimensional Detector. 13.4 Pixel Direct Diffraction Analysis. References. Appendix A. Values of Commonly Used Parameters. Appendix B. Symbols. Index.
An Interleaved AC–DC Converter Based on Current Tracking (2008)

In this paper, an interleaved AC-DC converter based on current tracking without any current sharing required is presented and applied to a two-phase flyback converter. This is realized using two critical-conduction-mode (CRM) pulsewidth-modulated chips, together with a field-programmable gate array technique. By doing so, not only are the total harmonic distortion and the power factor improved but the output power is also upgraded. In this paper, the circuit operation is described in detail, with some experimental results given to verify the proposed control scheme.
Detecting defects in software requirements specification (2014)

This research is concerned with detecting defects in software requirements specification. Motivated by both the problem of producing reliable requirements and the limitations of existing taxonomies to provide a satisfactory level of information about defects in the requirements phase, we focus on providing a better tool for requirements analysts. Only few attempts have been made to classify defects and defect detection techniques. Scattered knowledge about defects and defect detection techniques needs compilation and re-evaluation in order to enhance the ability to discover defects in the requirements phase. Toward this end, this work presents a taxonomy of requirements defects and the causes of their occurrences. The purpose is to reach a comprehensive understanding of both the sources of the problem and the solutions of possible defects and defect detection techniques. The taxonomy’s design is based on the analysis of each defect and its sources. In addition, this paper proposes a combined-reading technique for defects in requirements. The proposed technique avoids the shortcomings of other reading techniques. The result of applying the recommendations of this work specifically improves the quality of the requirements specification and generally software quality.
Ibrutinib Resistance Mechanisms and Treatment Strategies for B-Cell Lymphomas (2020)

Chronic activation of B-cell receptor (BCR) signaling via Bruton tyrosine kinase (BTK) is largely considered to be one of the primary mechanisms driving disease progression in B-Cell lymphomas. Although the BTK-targeting agent ibrutinib has shown promising clinical responses, the presence of primary or acquired resistance is common and often leads to dismal clinical outcomes. Resistance to ibrutinib therapy can be mediated through genetic mutations, up-regulation of alternative survival pathways, or other unknown factors that are not targeted by ibrutinib therapy. Understanding the key determinants, including tumor heterogeneity and rewiring of the molecular networks during disease progression and therapy, will assist exploration of alternative therapeutic strategies. Towards the goal of overcoming ibrutinib resistance, multiple alternative therapeutic agents, including second- and third-generation BTK inhibitors and immunomodulatory drugs, have been discovered and tested in both pre-clinical and clinical settings. Although these agents have shown high response rates alone or in combination with ibrutinib in ibrutinib-treated relapsed/refractory(R/R) lymphoma patients, overall clinical outcomes have not been satisfactory due to drug-associated toxicities and incomplete remission. In this review, we discuss the mechanisms of ibrutinib resistance development in B-cell lymphoma including complexities associated with genomic alterations, non-genetic acquired resistance, cancer stem cells, and the tumor microenvironment. Furthermore, we focus our discussion on more comprehensive views of recent developments in therapeutic strategies to overcome ibrutinib resistance, including novel BTK inhibitors, clinical therapeutic agents, proteolysis-targeting chimeras and immunotherapy regimens.
Geometrical technique to determine the influence of monochromatic aberrations on retinoscopy (1996)

A geometrical-optical analysis is developed to predict the reflex observed in retinoscopy. The analysis can be expanded to explain the reflex for an eye with aberrations. The succession of reflexes across the pupil for each position of the retinoscope is represented in a contour plot. The plots demonstrate that retinoscopy can be considered a measure of the transverse ray aberration of the eye. For an eye with simple defocus this causes the typical with and against motions observed with hyperopic and myopic refractive errors. For an eye with aberrations we predict more-complex retinoscopic reflexes. This theory is confirmed by actual measurements on a human eye with known aberrations.
Conjugation of soybean oil by decomposition of its iron tricarbonyl complex with carbon monoxide (1967)

Abstract Soybean and other vegetable oils are conjugated by decomposing their iron tricarbonyl complexes with carbon monoxide at elevated pressures. This procedure converts the iron tricarbonyl moiety of the complex into iron pentacarbonyl, which is recovered for reuse. When iron carbonyl‐complexed soybean oil is heated at 180‐200C at CO pressures of 1090‐3750 psi, 90‐97% of the complex is decomposed into Fe(CO) 5 and conjugated soybean oil. At 180C and 3600 psi CO, 84% of the Fe(CO) 5 is recovered, and 82% of the polyunsaturates in the oil is conjugated. At 200C and 1090 psi CO, 98% of the Fe(CO) 5 is recovered, but the oil is less conjugated (75%). The studies point the way to a possibly economical process for conjugating vegetable oils by consecutive reactions with Fe(CO) 5 and CO.
Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin. (1989)

The functional affinity and heterogeneity of autoantibodies to thyroglobulin (Tg) were measured by an IgG subclass-specific solid-phase competition ELISA in patients with autoimmune thyroid disease. High-affinity IgG1 and IgG4 antibodies formed the major anti-Tg response. Both titre and affinity of IgG3 and IgG2 anti-Tg were generally low but in some Hashimoto's disease patients high-affinity IgG2 anti-Tg were found and IgG2 anti-Tg, unlike those of other subclasses, showed very restricted heterogeneity. The affinity of IgG4 anti-Tg was similar in patients with thyroid disease and their clinically euthyroid (normal) relatives. In contrast, a progressive increase in IgG1 anti-Tg affinity was seen in clinically euthyroid individuals compared with their relatives with thyroid disease and high titred Hashimoto's disease patients, suggesting that either rising titres of high affinity IgG1 anti-Tg or affinity maturation of IgG1 anti-Tg may be indicative of impending hypothyroidism.
Characterization of Long-Chain Branching in Polyethylenes Using High-Field Carbon-13 NMR (1980)

The simplest polymer molecule examined for both its dynamic and structural characteristics utilizing carbon-13 nuclear magnetic resonance has been polyethylene. At first sight, a polymer molecule which is essentially a "polymethylene" would not seem to possess enough different structural characteristics to warrant more than a casual investigation. However, there are a variety of different polyethylenes available commercially that have substantially different physical properties and, subsequently, different end use applications. The fact that catalysts are sought to produce polyethylenes with desirable properties and that post treatments may be used to alter certain physical characteristics imply that there is a direct link between physical properties and molecular structure. This link between structure and properties and the commercial importance of polyethylene have brought about a need for a thorough structural characterization. Polyethylenes produced commercially via high pressure, free radical processes have densities around 0.92 g/cc and are referred to simply as "low density"
Structural Requirements for the BARD1 Tumor Suppressor in Chromosomal Stability and Homology-directed DNA Repair (2007)

The BRCA1 tumor suppressor exists as a heterodimeric complex with BARD1, and this complex is thought to mediate many of the functions ascribed to BRCA1, including its role in tumor suppression. The two proteins share a common structural organization that features an N-terminal RING domain and two C-terminal BRCT motifs, whereas BARD1 alone also contains three tandem ankyrin repeats. In normal cells, the BRCA1/BARD1 heterodimer is believed to enhance chromosome stability by promoting homology-directed repair (HDR) of double strand DNA breaks. Here we have investigated the structural requirements for BARD1 in this process by complementation of Bard1-null mouse mammary carcinoma cells. Our results demonstrate that the ankyrin and BRCT motifs of BARD1 are each essential for both chromosome stability and HDR. Tandem BRCT motifs, including those found at the C terminus of BARD1, are known to form a phosphoprotein recognition module. Nonetheless, the HDR function of BARD1 was not perturbed by synthetic mutations predicted to ablate the phospho-recognition activity of its BRCT sequences, suggesting that some functions of the BRCT domains are not dependent on their ability to bind phosphorylated ligands. Also, cancer-associated missense mutations in the BRCT domains of BARD1 (e.g. C557S, Q564H, V695L, and S761N) have been observed in patients with breast, ovarian, and endometrial tumors. However, none of these was found to affect the HDR activity of BARD1, suggesting that any increased cancer risk conferred by these mutations is not because of defects in this repair mechanism.
On prediction of bursty traffic in broadband satcom systems (2002)

For the purpose of traffic control in broadband satcom systems, it is required to predict the traffic descriptor for the next two round trip delay. The predicted traffic descriptor is used by earth-stations to shape their traffic in order to minimize traffic loss in the downlink queue and maximize the uplink utility. The paper investigates the application of neural networks or adaptive neuro fuzzy inference systems (ANFIS) in the prediction of bursty traffic and also application of neural networks in deriving the traffic descriptor. The result shows that the neural network approach is adequate for real time prediction of the traffic descriptor.
Efficient use of local edge histogram descriptor (2000)

The purpose of this paper is to show how the edge histogram descriptor for MPEG-7 can be efficiently utilized for image matching. Since the edge histogram descriptor recommended for the MPEG-7 standard represents only local edge distribution in an image, the matching performance for image retrieval may not be satisfactory. In this paper, to increase the matching performance, we propose to use the global and semi-local edge histograms generated directly from the local histogram bins. Then, the global, semi-global, and local histograms of two images are compared to evaluate the similarity measure. Since we exploit the absolute locations of edge in the image as well as its global composition, the proposed matching method is considered to be a more image content-based retrieval. Experimental results support this claim. Experiments on test images for MPEG-7 core experiment show that the proposed method yields better retrieval performance especially for semantic similarity.