gebhart/patrepeval huggingface dataset:
CIS AND TRANS β-AROYLACRYLIC ACIDS AND SOME DERIVATIVES<sup>1</sup> (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCIS AND TRANS β-AROYLACRYLIC ACIDS AND SOME DERIVATIVES1ROBERT E. LUTZ and GEORGE W. SCOTTCite this: J. Org. Chem. 1948, 13, 2, 284–296Publication Date (Print):March 1, 1948Publication History Published online1 May 2002Published inissue 1 March 1948https://pubs.acs.org/doi/10.1021/jo01160a018https://doi.org/10.1021/jo01160a018research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Apoptotic Activities of Wild-Type and Alzheimer's Disease-Related Mutant Presenilins in <i>Drosophila melanogaster</i> (1999)

Mutant human presenilins cause early-onset familial Alzheimer's disease and render cells susceptible to apoptosis in cultured cell models. We show that loss of presenilin function in Drosophila melanogaster increases levels of apoptosis in developing tissues. Moreover, overexpression of presenilin causes apoptotic and neurogenic phenotypes resembling those of Presenilin loss-of-function mutants, suggesting that presenilin exerts a dominant negative effect when expressed at high levels. In Drosophila S2 cells, Psn overexpression leads to reduced Notch receptor synthesis affecting levels of the intact approximately 300-kD precursor and its approximately 120-kD processed COOH-terminal derivatives. Presenilin-induced apoptosis is cell autonomous and can be blocked by constitutive Notch activation, suggesting that the increased cell death is due to a developmental mechanism that eliminates improperly specified cell types. We describe a genetic model in which the apoptotic activities of wild-type and mutant presenilins can be assessed, and we find that Alzheimer's disease-linked mutant presenilins are less effective at inducing apoptosis than wild-type presenilin.
Reducing the Activity and Secretion of Microbial Antioxidants Enhances the Immunogenicity of BCG (2009)

We conclude that antioxidants produced by BCG suppress host immune responses. These findings challenge the hypothesis that the failure of extensively cultivated BCG vaccines to prevent pulmonary tuberculosis is due to over-attenuation and suggest instead a new model in which BCG evolved to produce more immunity-suppressing antioxidants. By targeting these antioxidants it may be possible to restore BCG's ability to protect against pulmonary TB.
Achieving Secure Transmission with Equivalent Multiplicative Noise in MISO Wiretap Channels (2013)

In this letter, we verify that equivalent multiplicative noise, which is generally introduced by random beamforming security scheme, can also guarantee available secrecy rate in MISO wiretap channels. The multiplicative noise is transformed into additive one via a logarithmic operation which is further demonstrated to be information preserving. Then the achievable secrecy rate is quantitatively characterized when the amplitude and phase of the multiplicative noise are independently generated and follow lognormal and uniform distributions, respectively. Finally, power allocation between the multiplicative noise and the desired signal is optimized and discussed by numerical simulation when the eavesdropping channel is known.
Practical learning from one-sided feedback (2007)

In many data mining applications, online labeling feedback is only available for examples which were predicted to belong to the positive class. Such applications includespam filtering in the case where users never checkemails marked "spam", document retrieval where users cannotgive relevance feedback on unretrieved documents,and online advertising where user behavior cannot beobserved for unshown advertisements. One-sided feedback can cripple the performance of classical mistake-driven online learners such as Perceptron. Previous work under the Apple Tasting framework showed how to transform standard online learners into successful learners from one sided feedback. However, we find in practice that this transformation may request more labels than necessary to achieve strong performance. In this paper,we employ two active learning methods which reduce the number of labels requested in practice. One method is the use of Label Efficient active learning. The other method,somewhat surprisingly, is the use of margin-based learners without modification, which we show combines implicit active learning and a greedy strategy to managing the exploration exploitation tradeoff. Experimental results show that these methods can be significantly more effective in practice than those using the Apple Tasting transformation, even on minority class problems.
Bright light therapy decreases winter binge frequency in women with bulimia nervosa: A double-blind, placebo-controlled study (1999)

The study objective was to determine the effect of winter bright light therapy on binge and purge frequencies and depressive symptoms in subjects with bulimia nervosa. Thirty-four female bulimic outpatients were treated with either 10,000 lux bright white light or 50 lux dim red light (placebo control) during the winter months. In this double-blind study, the placebo group (n = 18) and the bright light group (n = 16) were matched for age, degree of seasonality (measured by the Seasonal Patterns Assessment Questionnaire [SPAQ]), and concurrent depression (measured by Structured Clinical Interview for DSM-IV [SCID]). Three weeks of baseline data collection were followed by 3 weeks of half-hour daily morning light treatment and 2 weeks of follow-up evaluation. There was a significant light-treatment by time interaction (Wilks' lambda = .81, F(2,28) = 3.31, P = .05). The mean binge frequency decreased significantly more from baseline to the end of treatment for the bright light group (F(1,29) = 6.41, P = .017) than for the placebo group. The level of depression (measured by daily Beck Depression Inventory [BDI] scores) did not significantly differ between the groups during any phase, and neither depression nor seasonality affected the response to light treatment. In this double-blind study, bulimic women who received 3 weeks of winter bright light treatment reported a reduced binge frequency between baseline and the active treatment period in comparison to subjects receiving dim red light.
Effect of Carvedilol on Ambulatory Blood Pressure, Renal Hemodynamics, and Cardiac Function in Essential Hypertension (1987)

A randomized, double-blind, placebo-controlled study was set up to study the effects of acute and chronic administration of carvedilol, a vasodilatory beta-blocker in essential hypertension. Acute administration of a single dose of 50 mg of carvedilol reduced systolic and diastolic blood pressure, without inducing reflex tachycardia. Renal blood flow was preserved; accordingly renal vascular resistance was significantly reduced. A significant reduction of glomerular filtration rate and filtration fraction was observed. Plasma renin activity (PRA) and plasma aldosterone were not changed. Chronic carvedilol treatment produced a significant fall in systolic and diastolic office and ambulatory blood pressure, heart rate, cardiac output, PRA and plasma aldosterone. Blood pressure variability was not changed. Renal blood flow, glomerular filtration rate and filtration fraction also remained unchanged; renal vascular resistance decreased significantly. It is concluded that carvedilol possesses definite antihypertensive and renal vasodilating properties, both acutely and after chronic treatment.
Pharmacogenomics and Acquired Long QT Syndrome (2005)

During the past decade pharmaceutical companies have been faced with the withdrawal of some of their marketed drugs because of rare, yet lethal, postmarketing reports associated with ventricular arrhythmias. The implicated drugs include antiarrhythmics, but also non-cardiac drugs, such as histamine blockers, antipsychotics, and antibiotics. These undesired effects involve prolongation of the QT interval, which may lead to characteristic ventricular tachyarrhythmias, known as torsades de pointes. These clinical symptoms of the acquired long QT syndrome (LQTS) are also found in an inherited form of the disease, called congenital LQTS. Nowadays, a number of environmental (non-genetic) and genetic risk factors for acquired LQTS have been described. Non-genetic factors include female gender, hypokalemia, and other heart diseases. The knowledge of genetic risk factors is emerging rapidly. During the last decade, mutations in several genes encoding ion channels have been shown to cause congenital LQTS. In acquired LQTS, a number of 'silent' mutation carriers in these LQTS genes have been identified, and functional polymorphisms in the same genes have been found that are associated with an increased vulnerability for the disease. Furthermore, there is also evidence that interindividual differences in drug metabolism, caused by functional polymorphisms in drug-metabolizing enzyme genes, may be a risk factor for acquired LQTS, especially if multiple drugs are involved. This review evaluates the current knowledge on these risk factors for acquired LQTS, with an emphasis on the genetic risk factors. It also assesses the potential to develop pharmacogenetic tests that will enable clinicians and pharmaceutical companies to identify at an early stage patients or individuals in the general population who are at risk of acquired LQTS.
State-of-the-Art of Soil and Water Conservation Soil and Water Conservation for Production and Environmental Protection Frederick R. Troeh J. Arthur Hobbs Roy L. Donahue (1981)

State-of-the-Art of Soil and Water Conservation Soil and Water Conservation for Production and Environmental Protection, by Troeh Frederick R. Hobbs J. Arthur Donahue Roy L.. Prentice-Hall, Englewood Cliffs, NJ, 1980, 718 p., illus., $24.95 (80-364). David E. Hill David E. Hill Department of Forestry & Horticulture Connecticut Agricultural Experiment StationNew Haven, CT Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 31, Issue 2, February 1981, Page 171, https://doi.org/10.2307/1308283 Published: 01 February 1981
Sound Speed Estimation From Time Of Arrivals: Derivation And Comparison With Tdoa-Based Estimation (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
[Vaccination against the human immunodeficiency virus]. (1995)

Much progress has been made in recent years in the development of anti-VIH vaccines. Nearly 20 such vaccines have reached phase 1 clinical study in seronegative volunteers. The responses invoked by these vaccines are, however, mediocre, both in quality (lack of cross over neutralisation in isolated "wild" viruses) and in their levels and length of action. New formulations of vaccines are under study, but their development is long and difficult, and researchers are still disarmed by the problem of the variability of the virus. Several years of study, both clinical and fundamental, will be necessary before an effective vaccine against HIV-1 is available.
Feedback effects in erbium-doped fiber amplifier/source for open-loop fiber-optic gyroscope (1997)

We have investigated rotation-dependent feedback effects in an erbium-doped fiber source for an open-loop fiber-optic gyroscope with fiber amplifier/source configuration. Average power and optical spectrum of the source output as well as of the amplified signal output were found to vary depending on the rotation rate, resulting in the distortion of the gyroscope output. The distorted gyroscope output could be quantitatively explained by a theoretical model with the assumption that the source power and the gain variation due to feedback depends primarily on the average feedback signal power. It was found that the distortion in gyroscope output due to rotation-dependent feedback can be minimized when the phase difference is modulated with an amplitude of 2.405 rad where the average feedback signal power becomes independent of the rotation rate.
Laser Radar Range Imaging Sensor For Commercial Applications (1987)

Advanced, three-dimensional laser ranging systems have taken robotic applications such as bin picking, robotic guidance, manipulative tasks, and inspection processes to a new level of technological sophistication. This optical radar provides three-dimensional vision for a robotic system. This then allows tasks to be completed that were not previously possible.
A Longitudinal Twin Study of Personality and Major Depression in Women (1993)

In women, the relationship between neuroticism and the liability to major depression is substantial and largely the result of genetic factors that predispose to both neuroticism and major depression.
Functional Characterization of Flagellin Glycosylation in <i>Campylobacter jejuni</i> 81-176 (2009)

The major flagellin of Campylobacter jejuni strain 81-176, FlaA, has been shown to be glycosylated at 19 serine or threonine sites, and this glycosylation is required for flagellar filament formation. Some enzymatic components of the glycosylation machinery of C. jejuni 81-176 are localized to the poles of the cell in an FlhF-independent manner. Flagellin glycosylation could be detected in flagellar mutants at multiple levels of the regulatory hierarchy, indicating that glycosylation occurs independently of the flagellar regulon. Mutants were constructed in which each of the 19 serine or threonines that are glycosylated in FlaA was converted to an alanine. Eleven of the 19 mutants displayed no observable phenotype, but the remaining 8 mutants had two distinct phenotypes. Five mutants (mutations S417A, S436A, S440A, S457A, and T481A) were fully motile but defective in autoagglutination (AAG). Three other mutants (mutations S425A, S454A, and S460A) were reduced in motility and synthesized truncated flagellar filaments. The data implicate certain glycans in mediating filament-filament interactions resulting in AAG and other glycans appear to be critical for structural subunit-subunit interactions within the filament.
An Optical Sensor for Spark-Ignition Engine Combustion Analysis and Control (1989)

<div class="htmlview paragraph">An in-cylinder optical sensor has been developed and tested for use in spark-ignition engine combustion analysis and control, This sensor measures the luminous emission in the near infrared region. Results of these tests show good correlation between the measured luminosity and traditional combustion parameters, such as location and magnitude of maximum cylinder pressure, and location and magnitude of maximum heat release. Engine performance indicators, such as the indicated mean effective pressure (IMEP), also can be determined accurately with the measured luminosity combined with other engine operating parameters, e.g. intake manifold pressure. In-cylinder air-fuel ratio can be determined with accuracy over an ensemble of 100 cycles.</div>
Pathogenetic Role for Early Focal Macrophage Infiltration in a Pig Model of Arteriovenous Fistula (AVF) Stenosis (2013)

Purpose Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.
Electronic Analysis of Electrostatic Pulse to Detect Imminent Jet Engine Gas-Path Failure. (1977)

A jet engine gas-path wear rate monitor has been designed and tested. The monitor observes gas-path component rubbing, chaffing, burning, or erosion by measuring the electrostatic charge in the engine exhaust. This system continuously monitors the exhaust during engine operation, and periodically checks the total metal content in the exhaust to determine the deterioration rate of gas-path components. The design of the monitor is based on 4000 hours of early TF41 electrostatic count data and on 2000 hours of recent analog tape recorded data produced by TF41 engines undergoing severe distresses. This thesis describes the theory and operation of the wear rate monitor. First the design and installation of the optimized probes is presented. Next the theory and operation of the analog and digital circuits in the wear rate monitor is discussed. Circuit diagrams are given for all of the electronic components of the monitor. Then the techniques for adapting the monitor to engines other than the TF41 turbofan engine are presented.
PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression (2017)

Our data shows that pure LCIS and LCIS co-existing with ILC have very similar SCNA profiles, supporting the hypothesis that LCIS is a true precursor lesion. We have provided evidence that over-expression of CCND1 may identify a subgroup of patients with pure LCIS who are more likely to develop invasive disease, in contrast to PIK3CA mutations, which occur too early in lobular tumorigenesis to be informative.
The LDL Receptor: Oligonucleotide‐Directed Mutagenesis of the Cytoplasmic Domain (2007)

Mutations at many different sites in the gene for the low density lipoprotein (LDL) receptor can cause the disease familial hypercholesterolaemia. A particularly interesting class of mutations includes those producing 'internalization-defective' receptors-receptors which are expressed on the cell surface and which bind LDL normally, but which fail to cluster in coated pits. This defect was first observed in fibroblasts from patient J.D. Cloning and sequencing of the terminal exons of J.D.'s internalization-defective LDL receptor gene revealed a single point mutation which caused the substitution of cysteine for tyrosine at residue 807. On the basis of this observation, we have used techniques of oligonucleotide-directed mutagenesis to make an extensive series of mutations in the full-length LDL receptor cDNA. Stable cell-lines expressing these mutant receptors have been analysed for receptor function. Of 13 different amino acids expressed at residue 807, only the aromatics tyrosine, phenylalanine and tryptophan allowed rapid internalization. Position 807 seems to be a particularly sensitive site, since neither substitution of a cysteine for residue 806 or 808 nor deletion of two triplets downstream had any effect on receptor internalization. In addition, a series of truncations localize the signals for internalization to the membrane-proximal 22 amino acid residues.
Inner Composition Alignment for Inferring Directed Networks from Short Time Series (2011)

Identifying causal links (couplings) is a fundamental problem that facilitates the understanding of emerging structures in complex networks. We propose and analyze inner composition alignment-a novel, permutation-based asymmetric association measure to detect regulatory links from very short time series, currently applied to gene expression. The measure can be used to infer the direction of couplings, detect indirect (superfluous) links, and account for autoregulation. Applications to the gene regulatory network of E. coli are presented.
Reaction of 3-phenylglycidic esters. Part 1. Stereoselective opening of the oxirane ring of trans-3-phenylglycidic esters with 2-nitrothiophenols and the effect of various catalysts thereon (1984)

In the reaction of 2-nitrothiophenol (2) with trans-3-phenylglycidic esters carrying various substituents on the benzene ring, both reactivity and stereoselectivity of the oxirane ring-opening of the glycidates were markedly influenced by the electronic nature of the substituents. The presence of electron-donating groups was favourable for both reactivity and the preferential formation of cis-opening products, while the reverse was true for electron-withdrawing groups. As a result of our investigation on the catalytic effect of various Lewis acids in the reaction of the 4-methoxy derivative (1) with (2), tin compounds were found to be effective catalysts for cis-opening and readily produced the threo-nitro ester (3a), a key intermediate for the synthesis of diltiazem (5).Isolation of the crystalline complex (adduct A) from the reaction of (2) with SnCl4 and its efficient catalytic activity similar to that of SnCl4 suggest that the transition state involves co-ordination of tin derivatives both with (2) and the epoxy oxygen of (1) to cause highly specific cis-opening.
A novel driving technology for a passive gate on a Lateral-IGBT (2009)

This paper presents a novel technology for automatic driving of the passive PMOS to improve a Lateral-IGBT switching performance. Though the former technology, which we had introduced, has very simple driving circuitry, it still needs some additional process or structural change. The novel technology eliminates these remained problems without decrease in device performance. Simulation results indicate advantage of the novel technology in total performance compared with results of the former technology. Besides, experimental results of the prototype IPD with the novel technology have indicated improved switching performance distinctly.
Model based CAOPC flow for memory chips to improve performance and consistency of RET solutions (2020)

Key factors for maximizing yield in a modern semiconductor fab for Memory device manufacturing include wafer critical dimension uniformity and accuracy control. Resolution Enhancement Techniques (RET) solutions for the highly repetitive arrayed memory devices have been driven by the need for perfect geometric consistency without compromising the lithographic quality. Traditionally, both optical proximity correction (OPC) and sub-resolution assist features (SRAFs) insertion for these repetitive cell-array structures have been dealt by applying manual hand-crafted or rule-based methods. But these can be prone to iterative human intervention, long runtimes and sub-par lithographic quality. This work adopts a pattern/property aware approach (PA)2 and cell-array OPC technology that leverage the inherent repetitive and hierarchical structure of the cell-array to ensure the lithographic quality and perfect geometric consistency and symmetry down to the level of feature edges with model-based OPC and rule-based SRAF solutions. The flow also demonstrates a drastic reduction in runtime and turn-around-time to mask tapeouts for the full chip (core and periphery).