gebhart/patrepeval huggingface dataset:
Direct measure of the low-density fractions of serum cholesterol (1991)

Data on total cholesterol (TC) and its distribution among the three solubilizing lipid fractions in human serum have been obtained from three independent laboratories, and binary linear correlations between TC and each of the various fractions are compared. Two sources used the approved double-enzymatic multistep Allain-Trinder reaction with absorption detection. In the third method, which is entirely new, a nonenzymatic chromogenic reaction and circular dichroism (CD) detection were used. TC results from all three sources are in excellent agreement. HDL-C values measured by both enzymatic methods also agree in their correlations with TC but these are quite different from the correlation observed between HDL-C and TC values obtained by the new nonenzymatic procedure. Reasons are given which suggest that the nonenzymatic method is more accurate for the measurement of the low-density lipid fractions and why health risk determinations that are based upon calculated values for this variable should be deemphasized until a more dependable procedure is approved for use.
Model transformation for object-relational database development (2007)

In this paper we define and formalize the model transformations that complete the methodological approach for the development of Object-Relational (OR) Databases (DB) proposed in MIDAS, a model driven methodology for the development of Web Information Systems. In this proposal the Platform Independent Model is the conceptual data model while the Platform Specific Model is the Object-Relational model that represents the OR DB schema. Since both of them will be represented in UML, we also summarize an UML profile for OR DB modeling. In this work we focus on the formalization of the mappings needed to get the OR DB schema from the conceptual data model. We have first specified them with natural language to later formalize them with graph transformation rules.
Alternative Splicing of Cyclooxygenase-1 mRNA in the Human Iris (2003)

In homogenates of the human iris, the nonsteroidal anti-inflammatory drug (NSAID) S(+)flurbiprofen has been reported to inhibit cyclooxygenase-1 (COX-1) 70-fold more potently than in human whole blood. We hypothesized that this difference may be due to alternative splicing of COX-1 mRNA in the human iris or in whole blood. In this study, we have identified a similar COX-1 splice variant (COX-1SV) in both tissues with comparable COX-1/COX-1SV expression ratios. Therefore, we conclude that the difference in IC(50) values of S(+)flurbiprofen towards COX-1 in the human iris and human whole blood is not related to differences in the occurrence of spliced COX-1.
Therapeutic targeting of mTOR in tuberous sclerosis (2009)

Failure in the regulation of mTOR (mammalian target of rapamycin) appears to be critical to the pathogenesis of the inherited disorder tuberous sclerosis and the related lung disease LAM (lymphangioleiomyomatosis). Both diseases are caused by mutations of TSC1 or TSC2 (TSC is tuberous sclerosis complex) that impair GAP (GTPase-activating protein) activity of the TSC1-TSC2 complex for Rheb, leading to inappropriate activity of signalling downstream of mTORC1 (mTOR complex 1). mTOR inhibitors are already used in a variety of clinical settings including as immunosuppressants, anticancer agents and antiproliferative agents in drug-eluting coronary artery stents. They also represent candidate therapies directed to the underlying molecular pathology in tuberous sclerosis and LAM. Phase I/II clinical trials of the mTORC1 inhibitor rapamycin have demonstrated reduction in size of tuberous-sclerosis- and LAM-associated renal tumours (angiomyolipomas) and some evidence for reversible improvement in lung function in patients with LAM. A case series of tuberous-sclerosis-associated brain tumours were also reported to shrink during rapamycin therapy. An important, although variable, feature of the tuberous sclerosis phenotype is learning difficulty. Recent studies in mouse models carrying heterozygous Tsc2 mutations demonstrated improvement in memory and learning deficits following treatment with rapamycin. These promising pre-clinical and early human trials are being followed by larger-scale randomized control trials of mTOR inhibitors for treatment of renal, lung and brain manifestations of TSC1- and TSC2-associated disease.
Regulation of O‐antigen chain length is required for <i>Shigella flexneri</i> virulence (1997)

It is shown that Shigella flexneri maintains genetic control over the modal chain length of the O-antigen polysaccharide chains of its lipopolysaccharide (LPS) molecules because such a distribution is required for virulence. The effect of altering O-antigen chain length on S. flexneri virulence was investigated by inserting a kanamycin (Km)-resistance cassette into the rol gene (controlling the modal O-antigen chain length distribution), and into the rfbD gene, whose product is needed for synthesis of dTDP-rhamnose (the precursor of rhamnose in the O-antigen). The mutations had the expected effect on LPS structure. The rol::Km mutation was impaired in the ability to elicit keratoconjunctivitis, as determined by the Serény test. The rol::Km and rfbD::Km mutations prevented plaque formation on HeLa cells, but neither mutation affected the ability of S. flexneri to invade and replicate in HeLa cells. Microscopy of bacteria-infected HeLa cells stained with fluorescein isothiocyanate (FITC)-phalloidin demonstrated that both the rol::Km and rfbD::Km mutants were defective in F-actin tall formation: the latter mutant showed distorted F-actin tails. Plasma-membrane protrusions were occasionally observed. Investigation of the location of IcsA (required for F-actin tail formation) on the cell surface by immunofluorescence and immunogold electron microscopy showed that while most rol mutant bacteria produced little or no cell-surface IcsA, 10% resembled the parental bacterial cell (which had IcsA at one cell pole; the rfbD mutant had IcsA located over its entire cell surface although it was more concentrated at one end of the cell). That the O-antigen chains of the rol::Km mutant did not mask the IcsA protein was demonstrated by using the endorhamnosidase activity of Sf6c phage to digest the O-antigen chains, and comparing untreated and Sf6c-treated cells by immunofluorescence with anti-IcsA serum.
Erythromycin. I. Properties and Degradation Studies<sup>1</sup> (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTErythromycin. I. Properties and Degradation Studies1Edwin H. Flynn, Max V. Sigal Jr., Paul F. Wiley, and Koert GerzonCite this: J. Am. Chem. Soc. 1954, 76, 12, 3121–3131Publication Date (Print):June 1, 1954Publication History Published online1 May 2002Published inissue 1 June 1954https://pubs.acs.org/doi/10.1021/ja01641a005https://doi.org/10.1021/ja01641a005research-articleACS PublicationsRequest reuse permissionsArticle Views1207Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fire Engines (1909)

Fire Engines Get access A. E. A. A. E. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s10-XI, Issue 264, 16 January 1909, Page 57, https://doi.org/10.1093/nq/s10-XI.264.57a Published: 16 January 1909
Willingness to pay for traceable pork: evidence from Beijing, China (2012)

Purpose The purpose of this paper is to discuss the evolution of the food traceability system in China, examine factors that affect consumers' perception of a food traceability system, and determine their willingness to pay for having the system. Design/methodology/approach Beijing, one of the largest pork markets in urban China, was chosen and 400 consumers were randomly interviewed using questionnaires and finally a logistic model was employed to analyze consumers' willingness to pay for traceable pork. Findings The authors found that consumers' perception of pork traceability system is subject to a comparatively low level. Purchasing of traceable pork is affected by gender, self‐evaluation of health, awareness of the traceability system, concern about food safety, and the stochastic price willing to pay. Originality/value The paper is the first to quantify Chinese consumers' valuation for traceable pork and it helps pork producers and marketers understand consumers' willingness to pay a small premium of 4.5 RMB/kg (0.7 USD) for traceable pork. This finding has imperative policy implications that could help the government deal with the high cost associated with the use of a pork traceability system.
The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification (2000)

The dHAND basic helix-loop-helix transcription factor is expressed in neurons of sympathetic ganglia and has previously been shown to induce the differentiation of catecholaminergic neurons in avian neural crest cultures. We now demonstrate that dHAND expression is sufficient to elicit the generation of ectopic sympathetic neurons in vivo. The expression of the dHAND gene is controlled by bone morphogenetic proteins (BMPs), as suggested by BMP4 overexpression in vivo and in vitro, and by noggin-mediated inhibition of BMP function in vivo. The timing of dHAND expression in sympathetic ganglion primordia, together with the induction of dHAND expression in response to Phox2b implicate a role for dHAND as transcriptional regulator downstream of Phox2b in BMP-induced sympathetic neuron differentiation.
Prevulcanization inhibitor of sulfur‐free thiuram vulcanization (1972)

Abstract On the basis of Mooney scorch measurements at 120°C and of continuous measurements of vulcanization in a Vuremo curemeter at 145°C, sulfenamides which function as inhibitors of the sulfur‐free thiuram vulcanization have been investigated. It was found that the actual prevulcanization inhibitor is 2‐mercaptobenzothiazole. Its formation from sulfenamides is activated by zinc dimethyldithiocarbamate since the vulcanization of rubber by thiuram disulfides in the presence of zinc oxide is always accompanied by the formation of zinc dithiocarbamate. It seems probable that the inhibition effect of 2‐mercaptobenzothiazole is attributable to the formation of a complex with zinc dimethyldithiocarbamate which decreases the reaction rate in the initial steps of the sulfur‐free thiuram vulcanization and thus causes the scorch delay.
A Robust Method for Airborne Video Registration Using Prediction Model (2008)

In order to generate high precision registration for airborne video with or without GPS data, this paper presents a new robust method to remove matching failures fast. Rather than registering each frame of the video sequence individually, which is popular in existing applications, our Predicted Progressive Sample Consensus (P-PROSAC) algorithm firstly predicts a movement model of camera from previous registering results and/or GPS data, and then use it to construct a set of ranked candidate correspondences, from which our P-PROSAC algorithm draws samples. Previous robust estimator-PROSAC has improved the efficiency of RANSAC estimator. However, it is under the assumption that the similarity measure predicts correctness of a match, which is strongly challenged by moving targets, repetitive patterns and noises. Our P-PROSAC uses a prediction model of camera movement which can best describe the character of inliers so as to find solutions much earlier. Experiments on real-world aerial video demonstrate that our approach can significantly reduce the calculation time.
Sensitivity and Chemical Sensitization of Silver Bromide Grain Faces of Different Crystallographic Index (1975)

It has been observed that unsensitized silver bromide grains of cubo-oclahedral shape form latent-image specks preferentially on the cubic faces for all levels and intensities of exposure. Sulphur sen itization of such grains leads to an increase in number of latent-image specks and to a shift in the preferred sites of lalent-image formation to octahedral faces. Reduction sensitization increases the number of latent-image specks on cubic faces but has no influence on speck location. The reduction centres are located on the edges of grains and can be bleached by heavy exposures. Latent-image specks are formed on all faces when unsensitized grains are exposed in halogen acceptor. If exposure of the grains is continued with the acceptor removed there is preferential bleaching of those specks formed on octahedl al faces during the first exposure.Broad interpretations of these observations are offered based on consideration of the surface structures of silver bromide and sensitization mechanisms.
A 40-Gb/s optical transceiver front-end in 45nm SOI CMOS technology (2010)

A low-power, 40-Gb/s optical transceiver front-end is demonstrated in a 45 nm silicon on insulator (SOI) CMOS technology. A modulator driver uses floating body devices to realize voltage swing of 2 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">PP</sub> with a small-signal gain of 7.6 dB over 33 GHz. The optical receiver consists of a transimpedance amplifier (TIA) and post-amplifier with 55-dB·Ω of transimpedance over 30 GHz. The group-delay variation is ±3.9 ps over the 3-dB bandwidth and the average input-referred noise density is 20.47 pA/√Hz. The TIA consumes 9 mW from a 1 V supply for a transimpedance figure of merit of 1874.5 Ω/pJ. To the author's knowledge, this represents the lowest power consumption for a transmitter and receiver operating at 40-Gb/s in a CMOS process.
Bathophenanthroline‐ruthenium(II) complexes as non‐radioactive labels for oligonucleotides which can be measured by time‐resolved fluorescence techniques (1988)

Abstract The specific attachment of bathophenanthroline‐ruthenium(II) complexes as non‐radioactive label molecules to synthetically 5′‐NH 2 ‐modified oligonucleotides is described. After excitation by light pulses, the fluorescence of these labels can be measured by a time‐resolved mode woth high sensitivity. No quenching takes place due to coupling of the Ru complexes to the DNA. Ru‐complex‐labelled oligonucleotides still hybridize specifically to complementary DNA sequences, and no quenching is observed in the course of the hybridization process.
Long‐Term Stability of Defibrillation Thresholds with Intrapericardial Defibrillator Patches (1993)

From March 1982 to May 1, 1992, 105 consecutive patients underwent initial implant of cardioverter defibrillators (ICD) at our institution. Twenty-nine patients (23 male and 6 female, average ejection fraction 32.24%) with ICD systems implanted via thoracotomy and either intra- or extrapericardial patches, had one or more revisions including 56 generator changes or staged implant procedures, three patch revisions, one patch lead fracture without revision, and one sensing lead revision. The time between pulse generator revisions averaged 19.5 months. Initial defibrillation threshold mean was 12.8 joules (n = 25); at first revision, 14.46 joules (n = 29), (P = NS); by fifth revision, 15.0 joules (n = 2), (P = NS). One patch was noted to be crinkled at 70 months; one patch had migrated by 39 months, and two patch leads had fractured at the costal margin by 69 and 90 months. One patient with marginal defibrillation thresholds had an additional patch placed at revision to an upgraded ICD unit. Once acceptable defibrillation threshold (DFT) is obtained, the long-term intrapericardial DFT remains stable unless a specific problem occurs. As a small, nonstatistically significant increase in DFT may occur, caution must be exercised in patients with marginal DFTs.
Distinguishing illness behaviour from physical pathology in patients with chronic low back pain (1985)

Principal Clinical Psychologist, Salford Health Authority, Salford, UK Consultant Orthopaedic Surgeon, Western Infirmary, Glasgow, UK
Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment (1994)

Commercial polychlorinated biphenyls (PCBs) and environmental extracts contain complex mixtures of congeners that can be unequivocally identified and quantitated. Some PCB mixtures elicit a spectrum of biochemical and toxic responses in humans and laboratory animals and many of these effects resemble those caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatic hydrocarbons, which act through the aryl hydrocarbon (Ah)-receptor signal transduction pathway. Structure-activity relationships developed for PCB congeners and metabolites have demonstrated that several structural classes of compounds exhibit diverse biochemical and toxic responses. Structure-toxicity studies suggest that the coplanar PCBs, namely, 3,3',4,4'-tetrachlorobiphenyl (tetraCB), 3,3',4,4',5-pentaCB, 3,3',4,4',5,5'-hexaCB, and their monoortho analogs are Ah-receptor agonists and contribute significantly to the toxicity of the PCB mixtures. Previous studies with TCDD and structurally related compounds have utilized a toxic equivalency factor (TEF) approach for the hazard and risk assessment of polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) congeners in which the TCDD or toxic TEQ = sigma([PCDFi x TEFi]n)+sigma([PCDDi x TEFi]n) equivalent (TEQ) of a mixture is related to the TEFs and concentrations of the individual (i) congeners as indicated in the equation (note: n = the number of congeners). Based on the results of quantitative structure-activity studies, the following TEF values have been estimated by making use of the data available for the coplanar and monoortho coplanar PCBs: 3,3',4,4',5-pentaCB, 0.1; 3,3',4,4',5,5'-hexaCB, 0.05; 3,3',4,4'-tetraCB, 0.01; 2,3,3',4,4'-pentaCB, 0.001; 2,3',4,4',5-pentaCB, 0.0001; 2,3,3',4,4',5-hexaCB, 0.0003; 2,3,3',4,4',5'-hexaCB, 0.0003; 2',3,4,4',5-pentaCB, 0.00005; and 2,3,4,4',5-pentaCB, 0.0002. Application of the TEF approach for the risk assessment of PCBs must be used with considerable caution. Analysis of the results of laboratory animal and wildlife studies suggests that the predictive value of TEQs for PCBs may be both species- and response-dependent because both additive and nonadditive (antagonistic) interactions have been observed with PCB mixtures. In the latter case, the TEF approach would significantly overestimate the toxicity of a PCB mixture. Analysis of the rodent carcinogenicity data for Aroclor 1260 using the TEF approach suggests that this response is primarily Ah-receptor-independent. Thus, risk assessment of PCB mixtures that uses cancer as the endpoint cannot solely utilize a TEF approach and requires more quantitative information on the individual congeners contributing to the tumor-promoter activity of PCB mixtures.
Vocationalism and Liberal Education: exploring the tensions (1994)

Vocationalism is distinguished from vocational education and distinctions are drawn between the various senses in which vocationalism or the pursuit of vocational 'relevance' can be understood. The burden of the argument of the essay is that vocationalism, understood as teaching skills in virtue of their putative vocational usefulness or relevance, is misguided both on prudential and educational grounds. A basis for some reconciliation between liberal and vocational learning is found in the fact that learning for its own sake and learning for vocational purposes need not be conceived as mutually exclusive activities.
Non‐steroidal anti‐inflammatory drugs and prostate cancer progression (1998)

Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prostate cancer has remained unclear. In particular, the potential for prostate cancer chemoprevention using non-steroidal anti-inflammatory drugs (cyclo-oxygenase inhibitors; NSAIDs) has received little attention. The purpose of our study was to investigate associations between prostate cancer risk and use of NSAIDs. A population-based case-control study was carried out over 13 months from 1996 in metropolitan Auckland, New Zealand. A total of 317 newly diagnosed prostate cancer cases (including 192 “advanced” cases) representative of all cancer cases in the study population were identified from urology clinic referrals and histology reports. A total of 480 age-matched controls were recruited following random selection from the study population using electoral rolls as the sampling frame. After adjusting for potential confounding by socio-economic status and dietary fat consumption, there was a trend toward reduced risks of advanced prostate cancer associated with regular use of total NSAIDs (RR = 0.73; 95% CI 0.50–1.07) and total aspirin (RR = 0.71; 95% CI 0.47–1.08). However, these associations failed to reach statistical significance at the usually accepted levels. Weaker inverse associations were found for total prostate cancers, which included a number of small, low-grade tumours of less clinical significance. These findings lend support to proposed underlying aetiological hypotheses which imply a role for cyclo-oxygenase activity in prostate cancer progression. Int. J. Cancer 77:511–515, 1998. © 1998 Wiley-Liss, Inc.
Synthesis and activity of Helicobacter pylori urease and catalase at low pH. (1997)

Low surrounding pH reduces activity of urease and synthesis of nascent urease, catalase, and presumably of most other proteins. This suggests that H pylori is not acidophilic although it tolerates short-term exposure to low pH.
On-Line Sorting of Wood Treated with Chromated Copper Arsenate Using Laser-Induced Breakdown Spectroscopy (2002)

This paper details the design, implementation, and field evaluation of an online detector system using laser-induced breakdown spectroscopy (LIBS) for the analysis of copper chromated arsenate (CCA) treated wood products. The LIBS-based instrument functioned by creating the laser-induced plasma directly on the sample surface while wood was translated under the detector system, and was successful in discriminating between CCA treated wood and untreated wood products based on the atomic emission signal of chromium. The system was optimized for plasma emission collection both in and out of the laser focal plane and temporally optimized for chromium analysis using a compact, non-intensified charge-coupled device (CCD)/spectrometer unit. Using either single laser pulse spectra or 5-shot and 10-shot spectral averages, the accuracy of LIBS-based analysis ranged from 92 to 100% for identifying both CCA treated and untreated wood samples from the waste stream at a construction and demolition debris recycling center. Additional implementation issues are discussed in the context of LIBS-based on-line sorting of construction and demolition wood debris.