gebhart/patrepeval huggingface dataset:
An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy (2015)

Abnormal regulation of the complement alternative pathway is associated with C3 glomerulopathy. Complement factor H is the main plasma regulator of the alternative pathway and consists of 20 short consensus repeat (SCR) domains. Although recombinant full-length factor H represents a logical treatment for C3 glomerulopathy, its production has proved challenging. We and others have designed recombinant mini-factor H proteins in which 'non-essential' SCR domains have been removed. Here, we report the in vitro and in vivo effects of a mini-complement factor H protein, FH<sup>1-5^18-20</sup>, using the unique factor H-deficient (Cfh-/-) mouse model of C3 glomerulopathy. FH<sup>1-5^18-20</sup> is comprised of the key complement regulatory domains (SCRs 1-5) linked to the surface recognition domains (SCRs 18-20). Intraperitoneal injection of FH<sup>1-5^18-20</sup> in Cfh-/- mice reduced abnormal glomerular C3 deposition, similar to full-length factor H. Systemic effects on plasma alternative pathway control were comparatively modest, in association with a short half-life. Thus, FH<sup>1-5^18-20</sup> is a potential therapeutic agent for C3 glomerulopathy and other renal conditions with alternative pathway-mediated tissue injury.
Éloge funèbre de M. Stéphane Gsell, membre de l'Académie (1932)

Michon Étienne. Éloge funèbre de M. Stéphane Gsell, membre de l'Académie. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 76ᵉ année, N. 1, 1932. pp. 7-13.
The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis (2001)

Activation of muscle-specific genes by members of the myocyte enhancer factor 2 (MEF2) and MyoD families of transcription factors is coupled to histone acetylation and is inhibited by class II histone deacetylases (HDACs) 4 and 5, which interact with MEF2. The ability of HDAC4 and -5 to inhibit MEF2 is blocked by phosphorylation of these HDACs at two conserved serine residues, which creates docking sites for the intracellular chaperone protein 14-3-3. When bound to 14-3-3, HDACs are released from MEF2 and transported to the cytoplasm, thereby allowing MEF2 to stimulate muscle-specific gene expression. MEF2-interacting transcription repressor (MITR) shares homology with the amino-terminal regions of HDAC4 and -5, but lacks an HDAC catalytic domain. Despite the absence of intrinsic HDAC activity, MITR acts as a potent inhibitor of MEF2-dependent transcription. Paradoxically, however, MITR has minimal inhibitory effects on the skeletal muscle differentiation program. We show that a substitution mutant of MITR containing alanine in place of two serine residues, Ser-218 and Ser-448, acts as a potent repressor of myogenesis. Our findings indicate that promyogenic signals antagonize the inhibitory action of MITR by targeting these serines for phosphorylation. Phosphorylation of Ser-218 and Ser-448 stimulates binding of 14-3-3 to MITR, disrupts MEF2:MITR interactions, and alters the nuclear distribution of MITR. These results reveal a role for MITR as a signal-dependent regulator of muscle differentiation.
Efficient production of [ <i>n</i> ]rotaxanes by using template-directed clipping reactions (2007)

In this article, we report on the efficient synthesis of well defined, homogeneous [n]rotaxanes (n up to 11) by a template-directed thermodynamic clipping approach. By employing dynamic covalent chemistry in the form of reversible imine bond formation, [n]rotaxanes with dialkylammonium ion (-CH(2)NH(2)(+)CH(2)-) recognition sites, encircled by [24]crown-8 rings, were prepared by a thermodynamically controlled, template-directed clipping procedure, that is, by mixing together a dumbbell compound containing a discrete number of CH(2)NH(2)(+)CH(2)- ion centers with appropriate amounts of a dialdehyde and a diamine to facilitate the [n]rotaxane formation. A 21-component self-assembly process is operative during the formation of the [11]rotaxane. The oligomeric dumbbells containing CH(2)NH(2)(+)CH(2)- ion recognition sites were prepared by a stepwise protocol. Several of the dynamic [n]rotaxanes were converted into their kinetically stable counterparts, first by reduction ("fixing") of imine bonds with the BH(3).THF complex, then by protonation of the complex by addition of acid.
Identification and evaluation of quantitative trait loci underlying resistance to multiple HG types of soybean cyst nematode in soybean PI 437655 (2014)

We performed QTL analysis for SCN resistance in PI 437655 in two mapping populations, characterized CNV of Rhg1 through whole-genome resequencing and evaluated the effects of QTL pyramiding to enhance resistance. Soybean cyst nematode (SCN, Heterodera glycines Ichinohe) is one of the most serious pests of soybean worldwide. PI 437655 has broader resistance to SCN HG types than PI 88788. The objectives of this study were to identify quantitative trait loci (QTL) underlying SCN resistance in PI 437655, and to evaluate the QTL for their contribution to SCN resistance. Two F6:7 recombinant inbred line populations, derived from cv. Williams 82 × PI 437655 and cv. Hutcheson × PI 437655 crosses, were evaluated for resistance to SCN HG types 1.2.5.7 (PA2), 0 (PA3), 1.3.5.6.7 (PA14), and 1.2.3.4.5.6.7 (LY2). The 1,536 SNP array was used to genotype the mapping populations and construct genetic linkage maps. Two significant QTL were consistently mapped on chromosomes (Chr.) 18 and 20 in these two populations. One QTL on Chr. 18, which corresponds to the known Rhg1 locus, contributed resistance to SCN HG types 1.2.5.7, 0, 1.3.5.6.7, and 1.2.3.4.5.6.7 (PA2, PA3, PA14, and LY2, respectively). Copy number variation (CNV) analysis by whole-genome resequencing showed that PI 437655 and PI 88788 had similar CNV at the Rhg1 locus. The QTL on Chr. 20 contributed resistance to SCN HG types 1.3.5.6.7 (PA14) and 1.2.3.4.5.6.7 (LY2). Evaluation of both QTL showed that pyramiding of Rhg1 and the QTL on Chr. 20 significantly improved the resistance to SCN HG types 1.3.5.6.7 (PA14) and 1.2.3.4.5.6.7 (LY2) in both populations. Our studies provided useful information for deploying PI 437655 as a donor for SCN resistance in soybean breeding through marker-assisted selection.
Solubility of Sucrose in Aqueous Glycerol and Propylene Glycol (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Sucrose in Aqueous Glycerol and Propylene GlycolMary W. Fey, C. M. Weil, and J. B. SegurCite this: Ind. Eng. Chem. 1951, 43, 6, 1435–1436Publication Date (Print):June 1, 1951Publication History Published online1 May 2002Published inissue 1 June 1951https://pubs.acs.org/doi/10.1021/ie50498a048https://doi.org/10.1021/ie50498a048research-articleACS PublicationsRequest reuse permissionsArticle Views625Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Reactive oxygen species contribute to the development of arrhythmogenic Ca<sup>2+</sup> waves during β‐adrenergic receptor stimulation in rabbit cardiomyocytes (2012)

While β-adrenergic receptor (β-AR) stimulation leads to positive inotropic effects, it can also induce arrhythmogenic Ca2+ waves. β-AR stimulation increases mitochondrial oxygen consumption and, thereby, the production of reactive oxygen species (ROS). We therefore investigated the role of ROS in the generation of Ca2+ waves during β-AR stimulation in rabbit ventricular myocytes. Isoproterenol (ISO) increased Ca2+ transient amplitude during systole, sarcoplasmic reticulum (SR) Ca2+ load and the occurrence of Ca2+ waves during diastole. These effects, however, developed at different time points during ISO application.While SR Ca2+ release and load reached a maximum level after 3 min, Ca2+ waves occurred at the highest frequency only after 6 min of ISO application.Measurement of intra-SR-free Ca2+ concentration ([Ca2+]SR) showed an initial increase of SR Ca2+ load followed by a gradual decline over time during ISO application. This decline of [Ca2+]SR was not due to decreased SR Ca2+ uptake, but instead was the result of increased SRCa2+ leak mainly in the form of Ca2+ waves. ISO application led to significant RyR phosphorylation at the protein kinase A (PKA)-specific site, which remained relatively stable throughout β-AR activation.Moreover, β-AR stimulation significantly increased ROS production after 4–6 min of ISO application. The ROS scavenger Tiron and the superoxide dismutase mimetic MnTBPA abolished the ISO-mediated ROS production. The mitochondria-specific antioxidant Mito-Tempo and an inhibitor of the electron transport chain, rotenone, also effectively prevented the ISO-mediated ROS production. Scavenging ROS during ISO application decreased the occurrence of Ca2+ waves and partially prevented augmentation of SRCa2+ leak, but did not affect the increase of Ca2+ transient amplitude. Treatment of myocytes with ISO for 15 min significantly reduced the free thiol content in RyRs. These data suggest that increased mitochondrial ROS production during β-AR stimulation causes RyR oxidation. Together with RyR phosphorylation, oxidation of RyRs increases diastolic SR Ca2+ leak to a critical level leading to the generation of arrhythmogenic Ca2+ waves.
Liquid-crystal shutter systems for time-multiplexed stereoscopic displays (1993)

Regulated cell death by apoptosis constitutes a primary host defense for counteracting invading viral pathogens. In recent years, advances in the field of apoptosis research have revealed that mitochondria and mitochondria-derived factors play a central role in regulating cellular commitment to apoptosis. Here we explore the role of viral proteins in modulating cell death pathways that are relayed via this mitochondrial checkpoint.
Quinine-induced immune thrombocytopenia associated with hemolytic uremic syndrome: a new clinical entity (1991)

Three patients are described who developed severe thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure after ingestion of quinine. In one patient, the same clinical findings recurred several months later after another exposure to quinine. Serum from one patient contained quinine-dependent IgG antibodies reactive with the platelet glycoprotein (GP) Ib/IX complex. In the second and third cases, serum contained IgG and IgM antibodies reactive with both the GP Ib/IX and IIb/IIIa complexes in the presence of quinine. Quinine appears to have induced both immune thrombocytopenia and the hemolytic uremic syndrome (HUS) in these individuals. Findings made in these cases may have implications for the pathogenesis of some forms of HUS.
Intake of unsaturated fatty acids and HDL cholesterol levels are associated with manifestations of atopy in adults (2003)

There is indication that HDL cholesterol also plays a role in the complex interaction of fat intake, metabolism and the manifestation of atopy in adults. These findings may contribute to the understanding of time trends and regional differences of allergies.
rbcR [correction of rcbR], a gene coding for a member of the LysR family of transcriptional regulators, is located upstream of the expressed set of ribulose 1,5-bisphosphate carboxylase/oxygenase genes in the photosynthetic bacterium Chromatium vinosum (1991)

An open reading frame, rbcR, was identified 226 bp upstream of rbcAB, i.e., the ribulose 1,5-bisphosphate carboxylase genes expressed in the phototrophic purple bacterium Chromatium vinosum. Several features reveal that rbcR encodes a member of the LysR family of transcriptional regulators, in which an anomalous content of lysine and arginine residues (Lys/Arg anomaly) was found. The expression of rbcR in Escherichia coli as a protein fused to the N-terminal region of beta-galactosidase led to reduced expression of rbcAB. Thus, rbcR is likely to encode a trans-acting transcriptional regulator of rbcAB expression in C. vinosum.
Notes - Polynitrogen Systems from the Hydrazinocarbonic Acids. Part IX. The Synthesis and Bromination of Some 5-Tetrazolyl and Related -hydrazones (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Polynitrogen Systems from the Hydrazinocarbonic Acids. Part IX. The Synthesis and Bromination of Some 5-Tetrazolyl and Related -hydrazonesF. Scott, W. Morrish, and J. ReillyCite this: J. Org. Chem. 1957, 22, 6, 692–694Publication Date (Print):June 1, 1957Publication History Published online14 April 2003Published inissue 1 June 1957https://pubs.acs.org/doi/10.1021/jo01357a606https://doi.org/10.1021/jo01357a606research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular chaperones and the cytoskeleton (1997)

Heat shock proteins, first observed because they are preferentially synthesized by organisms exposed to heat or other physiological stress, are also synthesized constitutively. These proteins are divided into several families, namely, HSP100, 90, 70, 60 (chaperonin), and the small heat shock/alpha-crystallin proteins. They enjoy a wide phylogenetic distribution and are important because they function as molecular chaperones, able to mediate many cellular processes through an influence on higher order protein structure. For example, molecular chaperones assist in the transport of proteins into mitochondria and chloroplasts, as well as influencing clathrin lattice dynamics, viral replication and transcriptional activation. Under conditions of stress, some molecular chaperones prevent denaturation of proteins while others may dissociate protein aggregates, refolding monomers derived therefrom or directing their proteolytic destruction. We present in this review an analysis of the emerging literature on the relationship between molecular chaperones and the cytoskeleton, a collection of polymeric structures consisting of microtubules, microfilaments and intermediate filaments. A recent development in this field is identification of the TCP-1 complex as the eukaryotic cytoplasmic chaperonin which directs folding of cytoskeletal proteins such as alpha/beta/gamma-tubulin, actin and centractin. Moreover, the TCP-1 complex is a centrosomal component, apparently involved in the nucleation of microtubules. Other molecular chaperones recognize one or more cytoskeletal elements and in most cases they modulate the assembly of and/or provide protection for their constituent proteins. For example, HSP70 protects the centrosome and perhaps intermediate filaments during heat shock, and like HSP90, it binds to microtubules. Small heat shock proteins interact with microfilaments and intermediate filaments, affect their polymerization and guard them from heat shock by a phosphorylation-dependent mechanism. We conclude that molecular chaperones have different but cooperative roles in the formation and function of the eukaryotic cell cytoskeleton.
A Collaborative Annotation Framework (2005)

This paper describes our system that enables members of a social network to collaboratively annotate a shared media collection. The problem is important since online social networks are emerging as conduits for exchange of everyday experiences. Our collaborative annotation system provides personalized recommendations to each user, based on (a) media features, (b) context, (c) commonsensical relationships and (d) linguistic relationships. We also develop novel concept specificity and abstractness/concreteness measures that further adapt the recommendations to the specific concept. Our preliminary user studies indicate that the system performs well and is more useful as compared to standard web browser recommendation schemes.
Zero Cost Test Point Insertion Technique to Reduce Test Set Size and Test Generation Time for Structured ASICs (2006)

Since structured application specific integrated chip (ASIC) products require very short turn around time, long automatic test pattern generation (ATPG) run time is undesirable. Large structured ASICs often require a large number of test patterns to achieve the desired fault coverage. This paper presents the first test point insertion technique for structured ASICs that can reduce test set sizes and ATPG run time. Only unused flip-flops in the structured ASIC design are used to implement test points, so the proposed technique does not incur any hardware overhead. Since test points are inserted during a post-layout step, considering both timing and layout information, hence test points can be inserted without changing the existing layout or routing. Novel gain functions are defined that specifically quantify the reduction in test volume and test time to select the best signal lines for inserting test points. The gain function described in this paper is also applicable to regular cell based ASICs. The proposed test point insertion technique can be used in conjunction with any compression technique (Jas et al., 2003) to further reduce the test volume. Experimental results clearly demonstrate the effectiveness and scalability of the proposed technique. Using less than 1% of extra flip-flops and very little run time for test point insertion, test generation time was reduced by up 42.9% and test data volume by up to 25.9% while also achieving a near 100% fault efficiency for very large industrial (400K-5M signal lines) designs
Facile Synthesis of Surfactant-Free Au Cluster/Graphene Hybrids for High-Performance Oxygen Reduction Reaction (2012)

Non-Pt noble metal clusters like Au clusters are believed to be promising high performance catalysts for the oxygen reduction reaction (ORR) at the cathode of fuel cells, but they still suffer big problems during the catalysis reactions, such as a large amount of the capping agents being on the surface and easy occurrence of dissolution and aggregation. To overcome these obstacles, here, we present a novel and general strategy to grow ultrafine Au clusters and other metal (Pt, Pd) clusters on the reduced graphene oxide (rGO) sheets without any additional protecting molecule or reductant. Compared with the currently generally adopted nanocatalysts, including commercial Pt/C, rGO sheets, Au nanoparticle/rGO hybrids, and thiol-capped Au clusters of the same sizes, the as-synthesized Au cluster/rGO hybrids display an impressive eletrocatalytic performance toward ORR, for instance, high onset potential, superior methanol tolerance, and excellent stability.
Volleyball: Shoulder Injuries and Rehabilitation (2002)

Volleyball has become one of the world's most popular participatory sports in recent years. There are many dynamic skills and movements needed to play the game. As a result, many acute and overuse injuries to the shoulder may occur. This article addresses the common injuries and rehabilitation recommendations for the shoulder injuries in the volleyball players.
Coherent analysis of argumentative discourse (2003)

R. Cohen (Computational Linguistics, vol.13, no.1-2, p.11-24, 1987) has described a model for the analysis of arguments that includes: (1) a theory of expected coherent structure, which is used to limit analysis to the reconstruction of particular transmission forms; (2) a theory of linguistic clues which assigns a functional interpretation to special words and phrases used by the speaker to indicate the structure of the argument; and (3) a theory of evidence relationships which includes the demand for pragmatic analysis to accommodate beliefs not currently held. The author summarizes the prescriptions for coherent analysis, with a view to their application in the translation of technical material.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Local concentration measurements in electrochemical deposition using a schlieren method (1991)

We report local concentration measurements of electrolyte in electrochemical deposition using a schlieren method. The intensity contrast of schlieren images is used to obtain concentration information. The images reveal active regions of the growth and thus provide excellent records to study the dynamics of electrochemical deposition processes. Quantitative results of local concentration measurements in the early stages of the growth agree well with recent model calculations.
A murine very late activation antigen-like extracellular matrix receptor involved in CD2- and lymphocyte function-associated antigen-1-independent killer-target cell interaction. (1990)

CD2 and lymphocyte function-associated antigen (LFA)-1 are well known as T cell adhesion molecules involved in killer-target cell interactions. However, our recent study revealed that molecule(s) other than CD2 and LFA-1 might be involved in the lymphokine-activated killer (LAK) cell cytotoxicity against certain target cells. In order to characterize such unknown molecules, we established a mAb (RMV-7) which could inhibit CD2/LFA-1-independent LAK cell cytotoxicity and binding to target cells at the effector site. The Ag identified by RMV-7 appeared on splenic T cells late after mitogenic stimulation and was a noncovalently linked heterodimer composed of a 140-kDa alpha-chain and a 95-kDa beta-chain. RMV-7 blocked LAK cell binding to fibronectin (FN), fibrinogen, and vitronectin but not that to laminin or type IV collagen, indicating that the RMV-7-defined molecule is a unique extracellular matrix receptor for FN, fibrinogen, and vitronectin. One of its ligand, FN, was found on the surface of several target cells, and LAK cell cytotoxicity against them was blocked by anti-FN antibody at the target site. Similarly, cytotoxicity of a H-2d-specific CTL clone was inhibited by RMV-7 and anti-FN antibody as well. These results indicate that a unique very late activation Ag-like extracellular matrix receptor on murine CTL and LAK cells contributes to target cell binding and cytotoxicity.