gebhart/patrepeval huggingface dataset:
Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production (1994)

Conference Article| February 01 1994 Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production Irene C. Green; Irene C. Green § *School of Biological Sciences, University of Sussex, Brighton, Sussex U.K. §To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar James M. Cunningham; James M. Cunningham *School of Biological Sciences, University of Sussex, Brighton, Sussex U.K. Search for other works by this author on: This Site PubMed Google Scholar Carol A. Delaney; Carol A. Delaney *School of Biological Sciences, University of Sussex, Brighton, Sussex U.K. Search for other works by this author on: This Site PubMed Google Scholar Maurice R. Elphick; Maurice R. Elphick †Sussex Centre for Neuroscience, University of Sussex, Brighton, Sussex U.K. Search for other works by this author on: This Site PubMed Google Scholar Jon G. Mabley; Jon G. Mabley *School of Biological Sciences, University of Sussex, Brighton, Sussex U.K. Search for other works by this author on: This Site PubMed Google Scholar Michael H. L. Green Michael H. L. Green ‡Medical Research Council Cell Mutation Unit, University of Sussex, Brighton, Sussex U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (1): 30–37. https://doi.org/10.1042/bst0220030 Article history Received: October 11 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Irene C. Green, James M. Cunningham, Carol A. Delaney, Maurice R. Elphick, Jon G. Mabley, Michael H. L. Green; Effects of cytokines and nitric oxide donors on insulin secretion, cyclic GMP and DNA damage: relation to nitric oxide production. Biochem Soc Trans 1 February 1994; 22 (1): 30–37. doi: https://doi.org/10.1042/bst0220030 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: IL-1β, interleukin-1β, TNF α, tumour necrosis factor α, l-NAME, Nω-nitro-l-arginine methyl ester, l-NMMA, Nω-monomethyl-l-arginine, SNAP, S-nitroso penicillamine, SIN-1, 3-morpholino-sydnonimine, SOD, superoxide dismutase, GSNO, S-nitrosoglutathione This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Molecular and functional analysis of the type III secretion signal of the <i>Salmonella enterica</i> InvJ protein (2002)

Central to the pathogenicity of Salmonella enterica is the function of a type III secretion system (TTSS) encoded within a pathogenicity island at centisome 63 (SPI-1). An essential component of this system is a supramolecular structure termed the needle complex. Proteins to be delivered into host cells possess specific signals that route them to the type III secretion pathway. In addition, some bacterial proteins have signals that deliver them to the secretion complex to either become their structural components or exert their function at that location. One of these proteins is InvJ, which controls the length of the needle substructure of the needle complex. In this study, we have analysed the signal that targets InvJ to the TTSS. We found that amino acid residues 4 to 7 of InvJ are necessary and sufficient to mediate secretion of InvJ or a reporter protein in a TTSS-dependent manner. InvJ secretion was found to be essential for its function in needle length determination, effector protein secretion and bacterial invasion of epithelial cells. Frameshift mutagenesis analysis indicated that the InvJ type III secretion signal sequence tolerates significant alterations in its amino acid sequence without affecting InvJ secretion. Introduction of silent mutations in the secretion signal coding sequence that result in drastically different predicted mRNA folds had no effect on InvJ secretion or expression.
A motion computation and interpretation framework for oceanographic satellite images (2002)

We present a motion computation and interpretation framework for oceanographic satellite images. This framework is based on the use of a non quadratic regularization technique in optical flow computation which preserves flow discontinuities. We also show that using an appropriate tessellation of the image according to an estimate of the motion field can improve optical flow accuracy and yields more reliable flows. A new formulation for the approximation of an oriented flow field is described. This allows us to consider an arbitrary polynomial phase portrait model for characterizing flow salient features. This new framework is used for processing oceanographic image sequences and presents an alternative to the very complex physical modelling techniques for ocean surface circulation computation.
Progress in the development of Helicobacter pylori strain typing methods. (1998)

Helicobacter pylori is very different from other Gram negative bacteria that inhabit the human gastroduodenal tract. Its success in adapting to colonise and persist in the stomach is reflected in key features such as unique chemical structure and architecture of lipopolysaccharide, sheathed flagella, genomic diversity, and potent urease activity. Strain diversity within the species is well established and so the challenge is to exploit variations in these features for developing relevant epidemiological typing methods.
Parlay X Web Services for Policy and Charging Control in Multimedia Networks (2012)

The paper investigates the capabilities of Parlay X Web Services for Policy and Charging Control (PCC) in managing all Internet-protocol-based multimedia networks (IMSs). PCC is one of the core features of evolved packet networks. It comprises flow-based charging including charging control and online credit control, gating control, and Quality of Service (QoS) control. Based on the analysis of requirements for PCC, the functionality for open access to QoS management and advanced charging is identified. Parlay X Web Services are evaluated for the support of PCC, and some enhancements are suggested. Implementation aspects are discussed, and Parlay X interfaces are mapped onto IMS control protocols. Use cases of Parlay X Web Services for PCC are presented.
Primary Hyperparathyroidism Surgical Management Since the Introduction of Minimally Invasive Parathyroidectomy (2005)

With high-quality localization and intraoperative parathyroid hormone level monitoring, MIP can be performed with equal cure rates as standard cervical exploration, with no present evidence of delayed recurrence.
Plasma chromatography of phosphorus esters (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlasma chromatography of phosphorus estersJ. M. Preston, F. W. Karasek, and S. H. KimCite this: Anal. Chem. 1977, 49, 12, 1746–1750Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/ac50020a029https://doi.org/10.1021/ac50020a029research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure (2016)

Genome-wide 3C technologies (Hi-C) are being increasingly employed to study three-dimensional (3D) genome conformations. Existing computational approaches are unable to integrate accumulating data to facilitate studying 3D chromatin structure and function. We present HSA ( http://ouyanglab.jax.org/hsa/ ), a flexible tool that jointly analyzes multiple contact maps to infer 3D chromatin structure at the genome scale. HSA globally searches the latent structure underlying different cleavage footprints. Its robustness and accuracy outperform or rival existing tools on extensive simulations and orthogonal experiment validations. Applying HSA to recent in situ Hi-C data, we found the 3D chromatin structures are highly conserved across various human cell types.
Vision-based Ego-motion Computing for Intelligent Vehicles (2007)

Accurate estimation of the vehicle ego-motion with regard to the road is a key element for computer vision-based assisted driving systems. In this method, we propose the use of a single camera onboard a road vehicle in order to provide an estimation of its longitudinal velocity by computational means. There are some clear benefits derived from the use of computer vision for ego-motion computation. On the one hand, vision is not subject to slippery, contrary to odometry-based systems. This permits to reduce cumulative errors to some extent. On the other hand, it allows the integration of ego-motion data into other vision-based algorithms for intelligent vehicles, avoiding thus the need for maintaining calibration between different sensors. Some drawbacks must nonetheless be mentioned, such as the small number of feature points normally present in typical road scenes. Conversely, the problem becomes quite the opposite in urban scenes, where really cluttered images must be handled. In this case, the number of feature points increases although most of the information contained in the image is due to outliers. We propose to obtain couples of road features, mainly composed of road markings, as the main source of information for computing vehicle ego-motion. Road markings are normally found in highways and country side roads, where the estimation of vehicle velocity is most useful. Additionally, the use of lane markings allows avoiding the use of complex direct methods [1], [2], [3] for motion estimation. Instead, motion stereo techniques are considered. Motion stereo has great practical advantages as a means for a vehicle to determine its precise distance from external objects. This technique has previously been deployed in the field of indoor robotics [4]. The method is based on sampling a dynamic scene rapidly (e.g., 25 images per second) and measuring the displacements of features relative to each other in the image sequence. Accuracy is another advantage of the method. While the vehicle continues to approach the detected features the accuracy of the measurement improves quickly as the distance decreases. In the sequel an extension of the method for road vehicles and some experimental results will be presented.
Streptomycin Resistant Variants Obtained from Recently Isolated Cultures of Tubercle Bacilli. (1948)

Streptomycin resistant variants were obtained from 25 out of 57 (43.5%) recently isolated strains of tubercle bacilli.
3-D extraction techniques for signal integrity analysis (2002)

In this survey paper we describe recently developed techniques for 3-D extraction of complicated interconnect structures which are both fast and sufficiently accurate to perform signal integrity analysis.
開發適用於鑑別不同地理來源水稻品種之SSR DNA 分子標誌 (2009)

Molecular markers are potentially useful for crop variety identification. International Seed Testing Association is currently developing DNA-based markers system of variety identification for four major crops including Zea mays (maize), Oryza sativa (rice), Triticum durum and Triticum aestivum (wheat), and Glycine max L Mer. (soybean). Previous researches conducted on rice variety identification focused on particular regions or countries. The object of this study was to select simple sequence repeat (SSR) markers from 54 fluorescently-labeled SSR markers in 11 multiplex panels for rice, using 192 lines originated from geographically diverse regions. After excluding 6 markers which were poorly amplified or difficult to score due to strong stutter with incomplete effect of adding terminal adenine, a group of 12 unlinked makers were selected based on their easiness to score, absent of null alleles, and polymorphic information content (PIC) value. Numbers of alleles per locus of the selected markers ranged from 5 to 26, with an average of 12.8. PIC values ranged from 0.64 to 0.9, with an average of 0.79. Principal coordinate analysis (PCoA) result of the 192 rice lines showed that there were two groups. All Taiwan japonica varieties and four Italian varieties were assigned to the smaller group, which consist of 56 lines. The larger group contained the other 136 lines, including three Taiwan indica varieties. The first three dimensions account for 17.7%, 6.44% and 5.41% of total variability respectively. The larger group was more diverse on the third dimension, indicating its higher genetic diversity. Cluster analysis result was similar to PCoA result. There were 27 unresolved pairs, including 39 lines, by using these 12 selected markers. The best combination analysis indicated that if choose properly, the number of markers may be further reduced to 9 with no effect on the resolution
Modes in chirowaveguides (1989)

We introduce here a new class of waveguides, chirowaveguides, which exhibit some novel and unique properties owing to electromagnetic chirality. These waveguides consist of cylindrical waveguides containing chiral, or optically active, materials. Owing to the optical activity of the material inside the waveguide, several unique and novel features are associated with this type of guided-wave structure. It is shown that these waveguides cannot support individual TE, TM, or TEM modes and that they exhibit mode bifurcation in hybrid modes. As an illustrative example the parallel-plate chirowaveguide is analyzed, and the corresponding dispersion relations and Brillouin diagrams are obtained. Some of the novel applications of chirowaveguides to integrated-optical devices and optical communications systems are presented.
Practices for Scaling Lean & Agile Development: Large, Multisite, and Offshore Product Development with Large-Scale Scrum (2010)

Lean and Agile Development for Large-Scale Products: Key Practices for Sustainable Competitive Success Increasingly, large product-development organizations are turning to lean thinking, agile principles and practices, and large-scale Scrum to sustainably and quickly deliver value and innovation. Drawing on their long experience leading and guiding lean and agile adoptions for large, multisite, and offshore product development, internationally recognized consultant and best-selling author Craig Larman and former leader of the agile transformation at Nokia Networks Bas Vodde share the key action tools needed for success. Coverage includes Frameworks for large-scale Scrum for multihundred-person product groupsTesting and building quality inProduct management and the end of the contract game between business and R&DEnvisioning a large release, and planning for multiteam developmentLow-quality legacy code: why its created, and how to stop itContinuous integration in a large multisite contextAgile architectingMultisite or offshore developmentContracts and outsourced development In a competitive environment that demands ever-faster cycle times and greater innovation, the practices inspired by lean thinking and agile principles are ever-more relevant. Practices for Scaling Lean & Agile Development will help people realize a lean enterpriseand deliver on the significant benefits of agility. In addition to the action tools in this text, see the companion book Scaling Lean & Agile Development: Thinking and Organizational Tools for Large-Scale Scrumfor complementary foundation tools.
Superconducting-cavity-stabilised oscillator of high stability (1972)

Superconducting Nb cavities of high Q factor have been used to stabilise Gunn-effect oscillators. These stabilised oscillators have given an r.m.s. frequency deviation σ(N = 2, r = 1.004, τ = 10) of (1.2±0.1)×10−13 for an averaging time of 10s.
<title>Transmission error detection, resynchronization, and error concealment for MPEG video decoder</title> (1993)

In this paper, we propose an error detection and a resynchronization algorithm in the decoding process of VLC and an error concealment technique for MPEG video decoder. A transmission error causes an error propagation in compressed video data, which in turn leads to objectionable degradation in picture quality. In order to minimize the effect of error propagation, we should resynchronize and recover the differentially coded symbols as fast as possible. The proposed algorithm is capable of resynchronizing the VLC until at least the next macroblock. Concerning the error concealment algorithm, more emphasis is laid upon the concealment of erroneous intra mode MBs. The proposed technique shows better performance than any other previous techniques especially in I-pictures and scene change pictures.
The microbiological oxidation of insect moulting hormones (1974)

Crustecdysone (I) is degraded by a lysed mycelium of the micro-organisms Rhizopus arrhizus, Rhizopus nigricans and Curvularia lunata to give poststerone (VI) which is then transformed into rubrosterone (VIII); makisterone A (II) behaves similarly, muristerone A (III) gives a new product, identified as 5β,11α-dihydroxy-poststerone (VII), and ecdysone (IV) is not affected by these micro-organisms.
Reactions during Vulcanization I—Influence of Zinc and Lead on Rate of Cure of Stocks Accelerated with Tetramethylthiuram Monosulfide<sup>1</sup> (1931)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions during Vulcanization I—Influence of Zinc and Lead on Rate of Cure of Stocks Accelerated with Tetramethylthiuram Monosulfide1H. C. Jones and Harlan A. DepewCite this: Ind. Eng. Chem. 1931, 23, 12, 1467–1471Publication Date (Print):December 1, 1931Publication History Published online1 May 2002Published inissue 1 December 1931https://pubs.acs.org/doi/10.1021/ie50264a042https://doi.org/10.1021/ie50264a042research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Development of High-specificity Antibodies against Renal Urate Transporters Using Genetic Immunization (2006)

Recently three proteins, playing central roles in the bidirectional transport of urate in renal proximal tubules, were identified: two members of the organic anion transporter (OAT) family, OAT1 and OAT3, and a protein that designated renal urate-anion exchanger (URAT1). Antibodies against these transporters are very important for investigating their expressions and functions. With the cytokine gene as a molecular adjuvant, genetic immunization-based antibody production offers several advantages including high specificity and high recognition to the native protein compared with current methods. We fused high antigenicity fragments of the three transporters to the plasmids pBQAP-TT containing T-cell epitopes and flanking regions from tetanus toxin, respectively. Gene gun immunization with these recombinant plasmids and two other adjuvant plasmids, which express granulocyte/ macrophage colony-stimulating factor and FMS-like tyrosine kinase 3 ligand, induced high level immunoglobulin G antibodies, respectively. The native corresponding proteins of URAT1, OAT1 and OAT3, in human kidney can be recognized by their specific antibodies, respectively, with Western blot analysis and immunohistochemistry. Besides, URAT1 expression in Xenopus oocytes can also be recognized by its corresponding antibody with immuno-fluorescence. The successful production of the antibodies has provided an important tool for the study of UA transporters.
DNA replication in cell-free extracts from <i>Xenopus</i> eggs is prevented by disrupting nuclear envelope function (1992)

The lectin, wheat germ agglutinin (WGA), has previously been shown to prevent transport into the cell nucleus. This paper shows that WGA also inhibits nuclear DNA replication, under the same conditions that prevent transport. Although WGA eliminates sperm nuclear DNA replication in a cell-free extract of Xenopus eggs, DNA synthesis on a single-stranded template proceeds normally. Inhibition of nuclear DNA replication is partially reversed by addition of N-acetylglucosamine, and completely reversed by triacetylchitotriose. Sensitivity to inhibition by WGA is greatest during the nuclear assembly phase, and nuclear formation on sperm chromatin is blocked. DNA replication in preformed nuclear templates is also sensitive to WGA inhibition. I propose that WGA blocks DNA replication by preventing nuclear transport. The data presented here also indicate that, under certain circumstances, the elongation stage of DNA replication does not proceed in the absence of an intact nuclear envelope. The roles of the nuclear envelope and active nuclear transport in DNA replication are discussed.
Resistance in Pepper (Capsicum annuum L.) to Western Flower Thrips [Frankliniella occidentalis (Pergande)] (1991)

A replicated greenhouse study was conducted to confirm the availability of resistance to western Rower thrips in pepper germplasm. Host-plant resistance ratings confirmed earlier observations that there is a considerable amount of variability within pepper germplasm for reaction to F. occidentalis. Plants of `Keystone Resistant Giant', `Yolo Wonder L', `Mississippi Nemaheart', `Sweet Banana', and `California Wonder' were resistant to the insect and exhibited only mild symptoms of damage. Plants of `Carolina Cayenne', `Santaka', and `Bohemian Chili', however, exhibited the symptoms of severe thrips damage, i.e., poorly expanded, deformed, and distorted leaves; greatly shortened internodes; and severe chlorosis. The resistance to F. occidentalis in pepper appears to be due to tolerance mechanisms, not antixenosis (nonpreference) or antibiosis mechanisms. Thrips-resistant cultivars could be used as a cornerstone in an integrated pest management program for greenhouse pepper production.