gebhart/patrepeval huggingface dataset:
Development of New HPLC Chiral Stationary Phases Based on Native and Derivatized Cyclofructans (2009)

An unusual class of chiral selectors, cyclofructans, is introduced for the first time as bonded chiral stationary phases. Compared to native cyclofructans (CFs), which have rather limited capabilities as chiral selectors, aliphatic- and aromatic-functionalized CF6s possess unique and very different enantiomeric selectivities. Indeed, they are shown to separate a very broad range of racemic compounds. In particular, aliphatic-derivatized CF6s with a low substitution degree baseline separate all tested chiral primary amines. It appears that partial derivatization on the CF6 molecule disrupts the molecular internal hydrogen bonding, thereby making the core of the molecule more accessible. In contrast, highly aromatic-functionalized CF6 stationary phases lose most of the enantioselective capabilities toward primary amines, however they gain broad selectivity for most other types of analytes. This class of stationary phases also demonstrates high "loadability" and therefore has great potential for preparative separations. The variations in enantiomeric selectivity often can be correlated with distinct structural features of the selector. The separations occur predominantly in the presence of organic solvents.
Four-dimensional fuel-optimal guidance in the presence of winds (1985)

The generation of optimal trajectories from cruise altitude to 10,000 ft for a typical commercial jet transport shows that the optimal absorption of delay in arrival time requires speed reduction in conjunction with altitude excursion (the latter not attempted before). Multiple regression methods are used to develop drag and fuel flow models which are smoother and more compact than those of any previous investigation. The concept of optimal cruise descent is introduced and optimal results are compared with suboptimal strategies of constant Mach number/Calibrated Airspeed (CAS) descent and constant flight path angle descent. Finally, wind effects are analyzed, and the cost of delay as a function of wind condition is presented, followed by the effects of wind on the constant flight path angle descent.
Serovar Determination and Molecular Taxonomic Correlation in Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum: A Cooperative Study of the International Working Group on Mycobacterial Taxonomy (1993)

A cooperative study was conducted by the International Working Group on Mycobacterial Taxonomy to correlate the agglutination serovar designations of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum strains with the species ascriptions of these organisms according to molecular criteria and cultural properties and to assess the reproducibility of serovar determinations for a set of 63 reference strains of these species. Among the molecular criteria, the level of agreement between results obtained with nucleic acid probes and T-catalase serology results was 94% for strains of M. avium and M. intracellulare. Nucleic acid probes were not available for M. scrofulaceum, but none of the 10 strains ascribed to this species on the basis of catalase serology data reacted with a nucleic acid probe for M. avium or M. intracellulare. Ascription to a species on the basis of mycolic acid high-performance liquid chromatography patterns was in agreement with catalase serology results in 86% of the cases examined. Most strains belonging to serovars 1 through 6 and 8 through 11 were identified by molecular criteria as M. avium, most strains belonging to serovars 7, 12 through 20, 23, and 25 were identified as M. intracellulare, and most strains belonging to serovars 41 through 43 were identified as M. scrofulaceum, in agreement with common current practice. Evidence for assigning serovar 27 to M. scrofulaceum was obtained. However, two strains of a given serovar may, on occasion, be placed in different species. The dominant species assignments for strains belonging to serovars 21, 24, 26, and 28 remain unresolved.(ABSTRACT TRUNCATED AT 250 WORDS)
Numerical modeling of self-propagating polymerization fronts: The role of kinetics on front stability (1997)

Frontal propagation of a highly exothermic polymerization reaction in a liquid is studied with the goal of developing a mathematical model of the process. As a model case we consider monomers such as methacrylic acid and n-butyl acrylate with peroxide initiators, although the model is not limited to these reactants and can be applied to any system with the similar basic polymerization mechanism. A three-step reaction mechanism, including initiation, propagation and termination steps, as well as a more simple one-step mechanism, were considered. For the one-step mechanism the loss of stability of propagating front was observed as a sequence of period doubling bifurcations of the front velocity. It was shown that the one-step model cannot account for less than 100% conversion and product inhomogeneities as a result of front instability, therefore the three-step mechanism was exploited. The phenomenon of superadiabatic combustion temperature was observed beyond the Hopf bifurcation point for both kinetic schemes and supported by the experimental measurements. One- and two-dimensional numerical simulations were performed to observe various planar and nonplanar periodic modes, and the results for different kinetic schemes were compared. It was found that stability of the frontal mode for a one-step reaction mechanism does not differ for 1-D and 2-D cases. For the three-step reaction mechanism 2-D solutions turned out to be more stable with respect to the appearance of nonplanar periodic modes than corresponding 1-D solutions. Higher Zeldovich numbers (i.e., higher effective activation energies or lower initial temperatures) are necessary for the existence of planar and nonplanar periodic modes in the 2-D reactor with walls than in the 1-D case. (c) 1997 American Institute of Physics.
Detection of masked anti-DNA antibodies in lupus sera by a monoclonal anti-idiotype. (1984)

We report here the use of a monoclonal anti-idiotype 3I to human anti-DNA antibodies to detect in serum idiotype-positive antigen-binding antibodies lacking DNA-binding activity as measured by conventional antigen binding assays. We studied paired serum samples from 13 patients with systemic lupus obtained at two times in the course of their disease: in each patient, one serum sample has anti-DNA activity and the second serum sample has no anti-dsDNA activity detectable by Millipore filter, ELISA, or Crithidia assay. Reactivity with 3I as detected with a radioimmunoassay (RIA) was present in all 13 sera with anti-dsDNA activity. Six patients showed a decrease in 3I reactivity to normal levels in the second serum sample, in which anti-dsDNA antibodies were not detectable by conventional antigen-binding assays. The other seven patients' second serum sample continued to show elevated 3I reactivity by RIA even though no anti-dsDNA activity was apparent. When the 3I-reactive antibodies from these latter patients' sera were eluted from a 3I affinity column, they revealed DNA-binding activity. Furthermore, dsDNA binding by these sera was apparent when they were displayed on Western blots of isoelectric focusing gels run in 8 M urea and incubated with radiolabeled dsDNA. These results indicate that the 3I anti-idiotype can detect anti-DNA antibodies in some sera of SLE patients that lack anti-DNA activity by ordinary assays. These antibodies may be inhibited in binding dsDNA by excess antigen or autologous anti-idiotype, and their DNA binding activity can be unmasked by procedures promoting immune complex dissociation.
Autoantibodies to thyroid peroxidase in patients with chronic thyroiditis: effect of antibody binding on enzyme activities. (1986)

Using thyroid peroxidase (TPO), which was purified from the thyroid of patients with Graves' disease, we attempted to determine whether sera from patients with chronic thyroiditis contained antibodies to the enzyme. When the binding was tested by ELISA, sera from patients with chronic thyroiditis revealed high binding activities to TPO. When TPO was incubated with IgG from sera followed by treatment with protein A-Sepharose and centrifugation, the remaining TPO activities in the supernatant fraction were lower in most of the patients, as compared to normal controls. Moreover, IgG purified by DEAE-cellulose chromatography from sera in patients interfered with the TPO activities. Titres of anti-TPO antibodies correlated well with those of anti-microsome antibodies. These results indicate the presence of autoantibodies to TPO in sera of most patients with chronic thyroiditis and that TPO may be one component of microsome antigen complexes recognized by the autoantibodies. Studies on the inhibition of TPO by IgG isolated from sera of patients using guaiacol and iodide assays revealed that at least three epitopes of TPO molecule were recognized by autoantibodies and that the antigenic determinants on TPO molecule recognized by autoantibodies could be heterogeneous in patients.
Polariton Wave Packet Propagation in the Exciton Resonance of a Semiconductor (1979)

This paper reports the first experimental observation of "slow" pulse propagation in the exciton-polariton resonance of a direct-gap semiconductor. The propagation delay of short light pulses transmitted through a 3.7-\ensuremath{\mu}m-thick GaAs crystal was measured directly with a cross-correlation technique. Polariton group velocities from $\frac{{c}_{\mathrm{vac}}}{3.6}$ down to $\frac{{c}_{\mathrm{vac}}}{2000}$ were found when the wave-packet center frequency was tuned through the $n=1$ exciton resonance.
Microfabricated atomic magnetometers (2013)

In this chapter, we discuss miniaturized atomic magnetometers, and the technology and applications relevant to this somewhat unusual direction in magnetometer research and development [1]. By “miniaturized,” we mean, in addition to their small size, magnetometers that have associated desirable qualities such as low power consumption, low cost, high reliability, and the potential for mass fabrication. Together with the high sensitivity usually obtained from the use of atoms, these properties result in magnetic sensors that fill a unique application space and may in fact enable new applications for which atomic magnetometers have not before been used.
Simultaneous saccharification and fermentation of cellulose to lactic acid (1991)

Recent interest in the industrial manufacture of ethanol and other organic chemicals from biomass has led to the utilization of surplus grain and cane juice as a fermentation feedstock. Since those starting materials are also foods, they are expensive. As an alternative, cellulosic substances-the most abundant renewable resources on earth(1)-have long been considered for conversion to readily utilizable hydrolyzates.(2, 3)For the production of ethanol from cellulose, we have proposed the simultaneous saccharification and fermentation (SSF) process.(4) In SSF, enzymatic cellulose hydrolysis and glucose fermentation to ethanol by yeast proceed simultaneously within one vessel. The process advantages-reduced reactor volume and faster saccharification rates-have been confirmed by many researchers.(5-8) During SSF, the faster saccharification rates result because the glucose product is immediately removed, considerably diminishing its inhibitory effect on the cellulase system.(9)To effectively apply the SSF method to produce substances fermented from glucose, several conditions should be satisfied. One is coincident enzymatic hydrolysis and fermentation conditions, such as pH and temperature. The other is that cellulase inhibition by the final product is less than that by glucose and/or cellobiose. One of us has reported that acetic acid, citric acid, itaconic acid, alpha-ketoglutaric acid, lactic acid, and succinic acid scarcely inhibit cellulase.(10) This suggests that if the microorganisms which produce these organic acids were compatible with cellulase reaction conditions, the organic acids could be produced efficiently from cellulosic substrates by SSF.In this article, the successful application of SSF to lactic acid production from cellulose is reported. Though there have been several reports of direct cellulose conversion to organic acids by anaerobes such as Clostridium, only trace amounts of lactic acid were detected in the fermentation medium among the low-molecular-weight fatty acid components.(11-13) Lactic acid is one of the most important organic acids and has a wide range of food-related and industrial applications.
Stages of separation (1996)

While family lawyers dealing with personal traumas of separation have developed an intuitive understanding of human nature, the transformation of this understanding into effective client management can be significantly enhanced by better familiarity with the nature and process of separation through divorce. Furthermore, as much of the behaviour of separating couples can be understood in bereavement terms, a familiarity with these concepts can assist in understanding events occurring after separation. Similarly, the separation experienced in divorce bears a close relationship to other separations in people's lives so that seeing it in a "life stage" framework can help lawyers place client behaviour in perspective. In helping people through the process of separation, family lawyers may benefit from [*2] a consideration of the origin and dynamics of the conflicting and ambivalent emotions experienced by some of their clients. Understanding these change processes can help lawyers allow clients to take control of their lives as they choose among options for the future with the support of a competent professional who is safeguarding their interests.
YTTRIUM-90 CHIMERIC L6 THERAPY IN NUDE MICE WITH HUMAN BREAST TUMORS (1994)

s: Fifth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer: Session VI: Experimental Radioimmunotherapy: PDF Only
Deuterium dilution as a method for determining total body water: effect of test protocol and sampling time (1994)

Deuterium dilution for the measurement of total body water (TBW) has been conducted using varying protocols for equilibration. We measured TBW from deuterium dilution in urine samples in twenty-eight subjects using three protocols: (1) early morning dosage without breakfast, measuring deuterium in a second voiding at 4 h and 6 h; (2) early morning dosage with breakfast with the same measurement times; (3) dosage as last consumption before overnight sleep, measuring deuterium in a second voiding at 10 h. Results were compared with TBW estimates from underwater weighing (UWW). Because UWW is an indirect measure of TBW, it is used as an independent reference method in order to compare only relative discrepancies between the two methods. TBW values in the fasted state were not significantly different from those obtained in the fed state. The urinary deuterium enrichment was higher at 4 h than at 6 h (resulting TBW differences: 0.6 (SD 0.4) l). At 4 h and 6 h, differences in TBW measurements from deuterium and densitometry were positively related to the amount of TBW, indicating incomplete equilibration in larger water compartments. At 10 h no such relationship existed, indicating complete mixing of deuterium. It is concluded that 10 h equilibration is preferable to the shorter 4 h and 6 h, for the determination of TBW.
Learning time-dependent noise to reduce logical errors: real time error rate estimation in quantum error correction (2017)

Quantum error correction is important to quantum information processing, which allows us to reliably process information encoded in quantum error correction codes. Efficient quantum error correction benefits from the knowledge of error rates. We propose a protocol for monitoring error rates in real time without interrupting the quantum error correction. Any adaptation of the quantum error correction code or its implementation circuit is not required. The protocol can be directly applied to the most advanced quantum error correction techniques, e.g. surface code. A Gaussian processes algorithm is used to estimate and predict error rates based on error correction data in the past. We find that using these estimated error rates, the probability of error correction failures can be significantly reduced by a factor increasing with the code distance.
Incubation Time Measurements in Thin‐Film Deposition (1997)

Studies on the initial growth or nucleation of materials and research on selective deposition often mention an incubation time. Many techniques exist to determine the incubation time. The outcome can be very different for each technique when the same nucleation process is considered. For the first time we have given a simple model which shows that several incubation times can be expected if different methods are used. One of the most popular methods, plotting the mass or thickness as a function of time and defining the incubation time as the intercept on the x-axis, is not a good method. In particular, a meaningful incubation time is found only if a layer-by-layer growth mechanism occurs right from the start. Ellipsometry can be used in situ and is a much more sensitive method, but this technique needs more research to correlate the nucleation process with the data obtained using this technique. The determination of the nucleus density using scanning electron microscopy or atomic force microscope is the most accurate method, yet needs a lot of experiments. Without a detailed description of the measurement method the incubation time is a meaningless quantity.
YN2 monolayer: Novel p-state Dirac half metal for high-speed spintronics (2017)

In spintronics, it is highly desirable to find new materials that can simultaneously possess complete spin-polarization, high-speed conduction electrons, large Curie temperature, and robust ferromagnetic ground states. Using first-principles calculations, we demonstrate that the stable YN2 monolayer with octahedral coordination is a novel p-state Dirac half metal (DHM), which not only has a fully spin-polarized Dirac state, but also the highest Fermi velocity (3.74 × 105 m/s) of the DHMs reported to date. In addition, its half-metallic gap of 1.53 eV is large enough to prevent the spin-flip transition. Because of the strong nonlocal p orbitals of N atoms (N-p) direct exchange interaction, the Curie temperature reaches over 332 K. Moreover, its ferromagnetic ground state can be well preserved under carrier doping or external strain. Therefore, the YN2 monolayer is a promising DHM for high-speed spintronic devices and would lead to new opportunities in designing other p-state DHMs.
Reduction of CO2 Emissions from Steel Plants by Using Steelmaking Slags for Production of Marketable Calcium Carbonate (2009)

By carbon dioxide mineralization, CO<sub>2</sub> can be stored safely and leakage-free for very long times. Owing to their high calcium content, steelmaking slags are suitable for mineral carbonatlon. In a country like Finland, where no suitable geological formations for CO<sub>2</sub> storage seem to exist, steelmaking slag carbonation offers an important CO<sub>2</sub> emissions reduction option for steel plants. If calcium could be extracted selectively from the slags prior to carbonation, a pure, and possibly marketable, calcium carbonate may be produced. This could replace some of the natural and synthetic CaCO<sub>3</sub> used in industry, combining savings in natural resources with CO<sub>2</sub> emissions reduction. Development work on the production of pure calcium carbonate from steelmaking slags by carbonation Is presented in this study. Selective extraction of calcium from steelmaking slags was investigated using various solvents. Precipitation of CaCO<sub>3</sub> from dissolved calcium at atmospheric pressure was also investigated. Amongst the various tested solvents ammonium salt solutions (NH<sub>4</sub>Cl, CH <sub>3</sub>COONH<sub>4</sub>, NH<sub>4</sub>NO<sub>3</sub>) were found to be the most promising for selectively extracting calcium from steel converter slag. These solvents dissolved calcium efficiently also from desulphurization slag, while extraction of calcium from two other types of slag was poor. CaCO <sub>3</sub> was successfully precipitated from the solution containing ammonium salt and dissolved steel converter slag.
A novel subtilase with NaCl-activated and oxidant-stable activity from Virgibacillussp. SK37 (2011)

The stability towards H2O2 and moderately halo- and thermo-tolerant properties of the AprX-SK37 enzyme are attractive for various biotechnological applications.
Motion-based recognition of pedestrians (2002)

In this paper we present an algorithm for recognizing walking pedestrians in sequences of color images taken from a moving camera. The recognition is based on the characteristic motion of the legs of a pedestrian walking parallel to the image plane. Each image is segmented into region-like image parts by clustering pixels in a combined color/position feature space. The proposed clustering technique implies matching of corresponding clusters in consecutive frames and therefore allows clusters to be tracked over a sequence of images. Based on the observation of clusters over time a two-stage classifier extracts those clusters which most likely represent the legs of pedestrians. A fast polynomial classifier performs a rough preselection of clusters by evaluating temporal changes of a shape-dependent clusters feature. The final classification is done by a time delay neural network (TDNN) with spatio-temporal receptive fields.
In control-regelingen in Nederland en de Verenigde Staten: een vergelijkende analyse (2021)

In control-regelingen in Nederland en de Verenigde Staten: een vergelijkende analyse In dit artikel onderzoeken de auteurs de nu al bestaande in control-regelingen in Nederland en vergelijken die met de bestaande wettelijke regeling van de in control-verklaring in de Verenigde Staten. Ook beantwoorden zij de vraag in hoeverre er verschillen tussen beide rechtsstelsels op dit terrein bestaan.
Purification and characterization of proteinase In, a trypsin‐like proteinase, in <i>Escherichia coli</i> (1992)

We previously found a trypsin-like proteinase which momentarily appears immediately before DNA synthesis in the cell cycle of Escherichia coli synchronized by phosphate starvation and which is closely related to the initiation of DNA replication (Kato, M., Irisawa, T., Morimoto, Y. and Muramatu, M., unpublished results). The proteinase was named proteinase In. It was purified approximately 2880-fold with a recovery of 15%. The isolated enzyme appeared homogeneous by gel filtration and electrophoresis. Its molecular mass was estimated by analytical gel filtration and SDS/PAGE as approximately 66 kDa. The isoelectric point of proteinase In is 4.9 and its optimal pH is approximately 9. Although protein In hydrolyzes fluorogenic substrate for trypsin, its hydrolytic activity seems markedly affected by amino-acid sequence lying towards the N-terminal from the P1 (lysine, arginine) residue. The proteinase does not hydrolyze N2-benzoyl-D,L-arginine-4-nitronanilide and fluorogenic substrates for chymotrypsin and elastase. The proteinase activity is inhibited by leupeptin, antipain and 4-nitrophenyl 4-guanidinobenzoate, but the effects of tosyl-L-lysine chloromethane, diisopropylfluorophosphate, benzamidine and pentamidine isethionate on the proteinase activity are weak or not inhibitory. Its activity is strongly affected in the presence of NaCl and KCl, and at a concentration of 1.5 M, these increase the activity 14-fold and 13-fold, respectively, above that without salt. Proteinase In was strongly inhibited by various esters of trans-4-guanidinomethylcyclohexanecarboxylic acid, and their inhibitory effects were roughly correlated with those on growth of E. coli. Proteinase activity was found in the cytoplasmic fraction.