gebhart/patrepeval huggingface dataset:
Numerical Analysis of Warpage and Reliability of Fan-out Wafer Level Package (2014)

최근 모바일 응용 제품에 사용되는 반도체 패키지는 고밀도, 초소형 및 다기능을 요구하고 있다. 기존의 웨이퍼 레벨 패키지(wafer level package, WLP)는 fan-in 형태로, I/O 단자가 많은 칩에 사용하기에는 한계가 있다. 따라서 팬 아웃 웨이퍼 레벨 패키지(fan-out wafer level package, FOWLP)가 새로운 기술로 부각되고 있다. FOWLP에서 가장 심각한 문제 중의 하나는 휨(warpage)의 발생으로, 이는 FOWLP의 두께가 기존 패키지에 비하여 얇고, 다이 레벨 패키지 보다 휨의 크기가 매우 크기 때문이다. 휨의 발생은 후속 공정의 수율 및 웨이퍼 핸들링에 영향을 미친다. 본 연구에서는 FOWLP의 휨의 특성과 휨에 영향을 미치는 주요 인자에 대해서 수치해석을 이용하여 분석하였다. 휨을 최소화하기 위하여 여러 종류의 epoxy mold compound (EMC) 및 캐리어 재질을 사용하였을 경우에 대해서 휨의 크기를 비교하였다. 또한 FOWLP의 주요 공정인 EMC 몰딩 후, 그리고 캐리어 분리(detachment) 공정 후의 휨의 크기를 각각 해석하였다. 해석 결과, EMC 몰딩 후에 발생한 휨에 가장 영향을 미치는 인자는 EMC의 CTE이며, EMC의 CTE를 낮추거나 Tg(유리천이온도)를 높임으로서 휨을 감소시킬 수 있다. 캐리어 재질로는 Alloy42 재질이 가장 낮은 휨을 보였으며, 따라서 가격, 산화 문제, 열전달 문제를 고려하여 볼 때 Alloy 42 혹은 SUS 재질이 캐리어로서 적합할 것으로 판단된다. For mobile application, semiconductor packages are increasingly moving toward high density, miniaturization, lighter and multi-functions. Typical wafer level packages (WLP) is fan-in design, it can not meet high I/O requirement. The fan-out wafer level packages (FOWLPs) with reconfiguration technology have recently emerged as a new WLP technology. In FOWLP, warpage is one of the most critical issues since the thickness of FOWLP is thinner than traditional IC package and warpage of WLP is much larger than the die level package. Warpage affects the throughput and yield of the next manufacturing process as well as wafer handling and fabrication processability. In this study, we investigated the characteristics of warpage and main parameters which affect the warpage deformation of FOWLP using the finite element numerical simulation. In order to minimize the warpage, the characteristics of warpage for various epoxy mold compounds (EMCs) and carrier materials are investigated, and DOE optimization is also performed. In particular, warpage after EMC molding and after carrier detachment process were analyzed respectively. The simulation results indicate that the most influential factor on warpage is CTE of EMC after molding process. EMC material of low CTE and high Tg (glass transition temperature) will reduce the warpage. For carrier material, Alloy42 shows the lowest warpage. Therefore, considering the cost, oxidation and thermal conductivity, Alloy42 or SUS304 is recommend for a carrier material.
Phosphorylation of the β-Amyloid Precursor Protein at the Cell Surface by Ectocasein Kinases 1 and 2 (2000)

The beta-amyloid precursor protein (betaAPP) is one of the rare proteins known to be phosphorylated within its ectodomain. We have shown previously that betaAPP can be phosphorylated within secretory vesicles and at the cell surface (Walter, J., Capell, A., Hung, A. Y. , Langen, H., Schnölzer, M., Thinakaran, G., Sisodia, S. S., Selkoe, D. J., and Haass, C. (1997) J. Biol. Chem. 272, 1896-1903). We have now specifically characterized the phosphorylation of cell surface-located betaAPP and identified two ectoprotein kinases that phosphorylate betaAPP at the outer face of the plasma membrane. By using selective protein kinase inhibitors and by investigating the usage of ATP and GTP as cosubstrates, we demonstrate that membrane-bound betaAPP as well as secreted forms of betaAPP can be phosphorylated by casein kinase (CK) 1- and CK2-like ectoprotein kinases. The ectodomain of betaAPP was also phosphorylated by purified CK1 and CK2 in vitro, but not by protein kinases A and C. Phosphorylation of betaAPP by ectoprotein kinases and by purified CK1 and CK2 occurred within an acidic domain in the N-terminal half of the protein. Heparin strongly inhibited the phosphorylation of cell-surface betaAPP by ecto-CK1 and ecto-CK2, indicating a regulatory role of this extracellular matrix component in betaAPP phosphorylation.
Variable Selection via Gibbs Sampling (1993)

Abstract A crucial problem in building a multiple regression model is the selection of predictors to include. The main thrust of this article is to propose and develop a procedure that uses probabilistic considerations for selecting promising subsets. This procedure entails embedding the regression setup in a hierarchical normal mixture model where latent variables are used to identify subset choices. In this framework the promising subsets of predictors can be identified as those with higher posterior probability. The computational burden is then alleviated by using the Gibbs sampler to indirectly sample from this multinomial posterior distribution on the set of possible subset choices. Those subsets with higher probability—the promising ones—can then be identified by their more frequent appearance in the Gibbs sample.
Spectroscopic and Structural Studies on Polyfluorophenyl Tellurides and Tellurium(IV) Dihalides (2001)

Bis(fluorophenyl) tellurides R2Te (R = C6F2H3 (1), CF3C6F4 (2), CF3C6F4OC6F4 (3), and C6F5 (4)) are synthesized by the facile reaction of Na2Te with bromo-fluorobenzenes, RBr. The corresponding bis(fluorophenyl)tellurium(IV) dihalides, R2TeHal2 (Hal = F, Cl, and Br) (5-16), are obtained by the oxidation of 1-4 with mild halogenating agents (XeF2, SO2Cl2, and Br2). The dihalides show temperature-dependent NMR spectra. On the basis of the 19F NMR spectra of the two series, (C6F2H3)2TeHal2 (Hal = F (5), Cl (9), and Br (13)) and R2TeCl2 (R = C6F2H3 (9), CF3C6F4 (10), CF3C6F4OC6F4 (11), and C6F5 (12)), the coalescence temperatures, T(c), and free enthalpies, DeltaG, of rotation of the TeC bonds are determined. The activation enthalpies for the dichlorides/dibromide 9-13 are in the range of 14.4-15.2 kcal mol(-1) and that for the difluoride 5 is considerably lower at 10.7 kcal mol(-1). In addition to thorough spectroscopic characterization of 1-16, the crystal structures of the monotellurides 2 and 4 as well as of the tellurium(IV) dihalides 5, 6, 9, 10, and 13 were determined. The dihalides show interesting intermolecular Te...Hal contacts, significantly shorter than the sum of the van der Waals radii, leading to different networks of association.
Real-time telephone-based speech recognition in the Jupiter domain (1999)

This paper describes our experiences with developing a real-time telephone-based speech recognizer as part of a conversational system in the weather information domain. This system has been used to collect spontaneous speech data which has proven to be extremely valuable for research in a number of different areas. After describing the corpus we have collected, we describe the development of the recognizer vocabulary, pronunciations, language and acoustic models for this system, the new weighted finite-state transducer-based lexical access component, and report on the current performance of the recognizer under several different conditions. We also analyze recognition latency to verify that the system performs in real-time.
Quantitative Digital Radiography Image Processing (2013)

This chapter contains sections titled: Introduction to flat-panel sensors Relation between physical quantities and radiographic acquisition Access to linear attenuation coefficients from the attenuation image Access to physical dimensions by combining several X-rays of a flat sensor Conclusion Bibliography
Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines (2015)

Recent clinical trials investigating receptor tyrosine kinase (RTK) inhibitors showed a limited clinical response in medulloblastoma. The present study investigated the role of micro-environmental growth factors expressed in the brain, such as HGF and EGF, in relation to the effects of hepatocyte growth factor receptor (MET) and epidermal growth factor receptor family (ErbB1-4) inhibition in medulloblastoma cell lines. Medulloblastoma cell lines were treated with tyrosine kinase inhibitors crizotinib or canertinib, targeting MET and ErbB1-4, respectively. Upon treatment, cells were stimulated with VEGF-A, PDGF-AB, HGF, FGF-2 or EGF. Subsequently, we measured cell viability and expression levels of growth factors and downstream signaling proteins. Addition of HGF or EGF phosphorylated MET or EGFR, respectively, and demonstrated phosphorylation of Akt and ERK1/2 as well as increased tumor cell viability. Crizotinib and canertinib both inhibited cell viability and phosphorylation of Akt and ERK1/2. Specifically targeting MET using shRNA's resulted in decreased cell viability. Interestingly, addition of HGF to canertinib significantly enhanced cell viability as well as phosphorylation of Akt and ERK1/2. The HGF-induced bypass of canertinib was reversed by addition of crizotinib. HGF protein was hardly released by medulloblastoma cells itself. Addition of canertinib did not affect RTK cell surface or growth factor expression levels. This manuscript points to the bypassing capacity of exogenous HGF in medulloblastoma cell lines. It might be of great interest to anticipate on these results in developing novel clinical trials with a combination of MET and EGFR inhibitors in medulloblastoma.
31.4: A Practical Method for Evaluating Viewing Angle Characteristics Based on CIECAM02 (2006)

Abstract We propose a practical method of evaluating viewing angle characteristics, which comprises CIECAM02 based index and CIECAM02 based hardcopy set. The method is tested over visual experiments and its accuracy and applicability are successfully confirmed.
The thermoelectric power of a semiconductor p-n heterojunction (2003)

Extended Ge-GaAs p-n heterojunctions were fabricated and studied. The thermoelectric power of the heterojunction was measured as a function of the temperature difference at the structure ends, which was varied from 10 to 180 K, while the average temperature was maintained constant at 300 K. It is found that experimental data obtained at a large temperature gradient are consistent with theoretical predictions that take into account the emergence of minority charge carriers due to thermal emission.
The small GTP-binding protein rab6 functions in intra-Golgi transport. (1994)

Rab6 is a ubiquitous ras-like GTP-binding protein associated with the membranes of the Golgi complex (Goud, B., A. Zahraoui, A. Tavitian, and J. Saraste. 1990. Nature (Lond.). 345:553-556; Antony, C., C. Cibert, G. Géraud, A. Santa Maria, B. Maro, V. Mayau, and B. Goud. 1992. J. Cell Sci. 103: 785-796). We have transiently overexpressed in mouse L cells and human HeLa cells wild-type rab6, GTP (rab6 Q72L), and GDP (rab6 T27N) -bound mutants of rab6 and analyzed the intracellular transport of a soluble secreted form of alkaline phosphatase (SEAP) and of a plasma membrane protein, the hemagglutinin protein (HA) of influenza virus. Over-expression of wild-type rab6 and rab6 Q72L greatly reduced transport of both markers between cis/medial (alpha-mannosidase II positive) and late (sialyl-transferase positive) Golgi compartments, without affecting transport from the endoplasmic reticulum (ER) to cis/medial-Golgi or from the trans-Golgi network (TGN) to the plasma membrane. Whereas overexpression of rab6 T27N did not affect the individual steps of transport between ER and the plasma membrane, it caused an apparent delay in secretion, most likely due to the accumulation of the transport markers in late Golgi compartments. Overexpression of both rab6 Q72L and rab6 T27N altered the morphology of the Golgi apparatus as well as that of the TGN, as assessed at the immunofluorescence level with several markers. We interpret these results as indicating that rab6 controls intra-Golgi transport, either acting as an inhibitor in anterograde transport or as a positive regulator of retrograde transport.
Distribution of receptors for granulocyte-macrophage colony-stimulating factor on immature CD34+ bone marrow cells, differentiating monomyeloid progenitors, and mature blood cell subsets (1994)

Biotin-labeled granulocyte-macrophage colony-stimulating factor (GM- CSF), in combination with phycoerythrin-conjugated streptavidin, enabled flow cytometric analysis of specific cell-surface GM-CSF receptors on rhesus monkey bone marrow (BM) and peripheral blood (PB) cells. GM-CSF receptors were readily detected on PB monocytes and neutrophils, but not on lymphocytes. In BM, GM-CSF receptors were identified on monocyte and neutrophil precursors and on subsets of cells that expressed the CD34 antigen. CD34+ cells with high GM-CSF- receptor expression coexpressed high levels of the class II major histocompatibility antigen RhLA-DR, whereas CD34+/RhLA-DRlow cells, which represent developmentally earlier cells, were either GM-CSF- receptor negative or expressed GM-CSF receptors at very low levels. The fluorescence histogram of CD34bright/RhLA-DRdull cells stained with biotin-GM-CSF showed that at least a fraction of these cells expressed low levels of GM-CSF receptors. CD34+ cells with high GM-CSF-receptor expression, purified by cell sorting, did not form colonies in culture or proliferate in response to GM-CSF. Instead, GM-CSF stimulation resulted in terminal differentiation into adherent cells, showing that these cells represented monocyte precursors. A distinct subset of CD34+ cells expressed GM-CSF receptors at low-to-intermediate levels and proliferated strongly in the presence of GM-CSF during short-term culture, but produced very few erythroid or monomyeloid colonies after longer culture periods. Most colony-forming cells, also those responsive to GM-CSF alone, were recovered in the subset of CD34+ cells on which GM-CSF receptors were virtually undetectable. These cells showed weaker proliferation in short-term proliferation assays than the CD34+/GM-CSF-receptor-intermediate cells, consistent with an immature phenotype. The results show that GM-CSF-receptor expression is initiated in a subset of immature, CD34bright/RhLA-DRdull cells and is progressively increased during differentiation into mature granulocytes and monocytes. The method used provides a new way to deplete developmentally early CD34+ cell of differentiating granulocyte and monocyte precursor cells.
Effect of Submicrometer Transducer Spacing on the Readback Signal in Saturation Recording (1975)

Experimental results for frequency response and halfpulse width of digital recording signals have been obtained for submicrometer transducer spacings, for the case of a flexible disk flying in close proximity to a rigidly mounted conventional ferrite recording head. Using optical flying heights rather than an “effective spacing,” together with a modification of the Williams-Comstock write-process slope criterion, we have obtained excellent agreement between experimental results and theoretical predictions. This suggests that the notion of effective spacing can be avoided.
Immunogenicity of Subcutaneous Versus Intramuscular Oka/Merck Varicella Vaccination in Healthy Children (1991)

To compare the immunogenicity and safety of varicella vaccine by either subcutaneous or intramuscular injection, 166 healthy children aged 12 months to 10 years old who had no prior history of varicella were enrolled from two pediatric practices and randomly assigned to receive 0.5 mL of a single lot of varicella vaccine. Sera from the day of and 6 weeks postvaccination were tested for varicella antibody by gpELISA. Parents recorded clinical events occurring in the 6 weeks following vaccination. In the 132 evaluable children, the mean prevaccination titer was 0.3 gpELISA units for both groups. Sixty-three (97%) of the 65 receiving varicella vaccine by the subcutaneous route seroconverted compared with 67 (100%) of 67 immunized intramuscularly. Postvaccination geometric mean titer in the subcutaneous group was 6.9 +/- 7.0 gpELISA units and did not differ significantly from the geometric mean titer of 10.5 +/- 4.4 in the intramuscular group. Varicella vaccine was generally well tolerated by either route; 21% of both groups complained of reactions at the injection site and 7% had a varicella-like rash. Although varicella vaccine is recommended to be given subcutaneously, the results of this study indicate that inadvertent intramuscular administration of varicella vaccine is not reason for revaccination.
Tibiotalocalcaneal arthrodesis for arthritis and deformity of the hind part of the foot. (1988)

We devised a method for tibiotalocalcaneal arthrodesis to treat deformities or degenerative arthritis, or both, that involve the tibiotalar and talocalcaneal joints. Satisfactory results were obtained in approximately 75 per cent of twenty-one patients; osseous union was radiographically evident in all but three patients. Secondary degenerative changes in the adjacent joints were not evident radiographically during a period of follow-up that ranged from 2.5 to seven years.
Dynamic focus in optical coherence tomography for retinal imaging (2006)

Imaging the human retina still represents the main field of application of optical coherence tomography (OCT). A major advantage of OCT is the decoupling of depth resolution (given by the coherence length of the light source) and transverse resolution (given by the focal spot size). This enables images of the retina with high depth resolution. On the other hand, in most OCT systems, a limited transverse resolution has been accepted to provide a sufficiently large (approximately 1 mm) depth of focus. However, to obtain images with high transverse resolution throughout the whole depth of the retina (especially in the nerve head region) a tracking of coherence gate and focus position (dynamic focus) is essential. This study realizes a dynamic focus in a time domain transversal (en face) scanning system for retinal imaging. We show that maintenance of a transverse resolution of approximately 4.4 microm can be achieved over an optical depth of 1 mm in a model eye and apply our method to imaging the human retina in vivo.
Distributed Second-Order Optimization using Kronecker-Factored Approximations (2017)

As more computational resources become available, machine learning researchers train ever larger neural networks on millions of data points using stochastic gradient descent (SGD). Although SGD scales well in terms of both the size of dataset and the number of parameters of the model, it has rapidly diminishing returns as parallel computing resources increase. Second-order optimization methods have an affinity for well-estimated gradients and large mini-batches, and can therefore benefit much more from parallel computation in principle. Unfortunately, they often employ severe approximations to the curvature matrix in order to scale to large models with millions of parameters, limiting their effectiveness in practice versus well-tuned SGD with momentum. The recently proposed K-FAC method(Martens and Grosse, 2015) uses a stronger and more sophisticated curvature approximation, and has been shown to make much more per-iteration progress than SGD, while only introducing a modest overhead. In this paper, we develop a version of K-FAC that distributes the computation of gradients and additional quantities required by K-FAC across multiple machines, thereby taking advantage of method’s superior scaling to large mini-batches and mitigating its additional overheads. We provide a Tensorflow implementation of our approach which is easy to use and can be applied to many existing codebases without modification. Additionally, we develop several algorithmic enhancements to K-FAC which can improve its computational performance for very large models. Finally, we show that our distributed K-FAC method speeds up training of various state-of-the-art ImageNet classification models by a factor of two compared to Batch Normalization(Ioffe and Szegedy, 2015).
Distress and Quality of Life Concerns of Family Caregivers of Patients Undergoing Palliative Surgery (2008)

There has been limited research in the field of palliative care and even far less focus on the area of palliative surgery. Although patient needs are paramount, family caregivers require information and support at the time surrounding surgery for advanced disease. The aim of this prospective cohort study of family caregivers of patients with advanced malignancies was to measure the impact of palliative surgery on dimensions of quality of life (QOL) for these family members. Family caregivers completed assessment tools preoperatively and at approximately 3 weeks and 2 and 3 months postoperatively. Parameters of physical, psychological, social, and spiritual QOL were measured on a scale of 0 (poor) to 10 (good) using the City of Hope QOL-Family instrument. Caregivers recorded their general distress on the Distress Thermometer using a scale of 0 (none) to 10 (severe). Analysis of the data revealed that family caregivers had disruptions similar to patients in physical, psychological, social, and spiritual dimensions of QOL. Findings suggest that caregivers should be assessed for distress and QOL concerns both before and after surgery for patients with advanced malignancies. Although caregiver concerns cannot always be eradicated, resources and interventions to support family caregivers are vital to improving QOL.
Robust speed control of DC servomotors using modern two degrees-of-freedom controller design (1991)

The authors propose a robust speed control system for DC servomotors based on the parametrization of two-degree-of-freedom controllers. The servosystems can dramatically improve the characteristics of the closed loop systems, i.e. the disturbance torque suppression performance and the robustness to system parameter variations, without changing the command input response. The excellent control performances obtained during laboratory experiments by using a microprocessor-based controller are shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Summer School Remedial Biology: An Innovative Approach (1991)

Research Article| March 01 1991 Summer School Remedial Biology: An Innovative Approach Stanford R. Hill, Jr., Stanford R. Hill, Jr. Search for other works by this author on: This Site PubMed Google Scholar Paul B. Hounshell Paul B. Hounshell Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1991) 53 (3): 176–178. https://doi.org/10.2307/4449255 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Stanford R. Hill, Jr., Paul B. Hounshell; Summer School Remedial Biology: An Innovative Approach. The American Biology Teacher 1 March 1991; 53 (3): 176–178. doi: https://doi.org/10.2307/4449255 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright 1990 National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
An <i>in Vitro</i> Assay for Cellular Hypersensitivity in Man (1970)

Abstract A reproducible in vitro assay for delayed hypersensitivity in man is described. Human blood lymphocytes from subjects exhibiting delayed hypersensitivity can be stimulated by specific antigen in vitro to produce a soluble factor which inhibits the migration of normal guinea pig peritoneal exudate cells from capillary tubes. The production by lymphocytes of this migration inhibitory factor (MIF) is immunologically specific. Nonsensitive lymphocytes are not sensitized by plasma factors to produce MIF. Some clinical applications of this in vitro assay are discussed.