gebhart/patrepeval huggingface dataset:
Ferrofluid soft-robot bio-inspired by Amoeba locomotion (2015)

This paper presents a novel application based on the bio-inspired motion of the Amoeba. This research is focused on development a soft micro robot based on the Amoeba locomotion which can be named Whole Skin Locomotion. The robot is created using the fluid filled toroid method that acts as a body shaping feature with ferrofluid material placed within that is delivered to create the driving force. The passive fluid switch acts as an active sensitive liquid when a magnetic field is applied. Therefore, based on this behaviour in order to produce the driving motion external Electromagnetic coils are arranged as a wireless control and actuator. A number of motions and hindrances are currently presented to insure the principal motions of the robot. Some other approaches of ferrofluid soft-robot biomimetic inspired are also presented as well.
Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients (1997)

The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15 APL patients at relapse after all-trans retinoic acid (ATRA) induced and chemotherapy maintained complete remission (CR). As2O3 was administered intravenously at the dose of 10 mg/d. Clinical CR was achieved in nine of 10 (90%) patients treated with As2O3 alone and in the remaining five patients treated by the combination of As2O3 and low-dose chemotherapeutic drugs or ATRA. During the treatment with As2O3, there was no bone marrow depression and only limited side effects were encountered. Pharmacokinetic studies, which were performed in eight patients, showed that after a peak level of 5.54 micromol/L to 7.30 micromol/L, plasma arsenic was rapidly eliminated, and the continuous administration of As2O3 did not alter its pharmacokinetic behaviors. In addition, increased amounts of arsenic appeared in the urine, with a daily excretion accounting for approximately 1% to 8% of the total daily dose administered. Arsenic contents in hair and nail were increased, and the peak content of arsenic could reach 2.5 to 2.7 microg/g tissue at CR. On the other hand, a decline of the arsenic content in hair and nail was observed after withdrawal of the drug. We conclude that As2O3 treatment is an effective and relatively safe drug in APL patients refractory to ATRA and conventional chemotherapy.
A Virtual Socket Framework for Rapid Emulation of Video and Multimedia Designs (2005)

Traditional design and test of complex multimedia systems involves a large number of test vectors and is a difficult and time-consuming task. The simulation times are prohibitively long on current desktop computers. Driving actual design scenarios and timing burst behavior which produce real-time effects is difficult to do with current simulation environments. This paper describes a rapid emulation framework for accessing multiple hardware IP blocks on an FPGA. This solution involves an abstraction of the FPGA platform by having a virtual socket layer that resides between the design and the test vehicles. A rapid prototyping platform is thus created, and its use with complex video and multimedia systems is described
A navigation and reservation based smart parking platform using genetic optimization for smart cities (2017)

With the development of technology, smart devices are becoming more common in everyday life. The development of devices that can connect to the Internet and transmit data has been a source of inspiration for smart city designs. The common problem in our cities is the difficulty of finding free parking slots. The parking problem causes traffic to congest and people who go to work are looking for a place. In this study, a navigation and reservation based parking proposal system was developed for smart cities. The proposed method involves the development of small devices that send data to the internet using the internet of things (IoT) technology. The free parking space closest to the current location is found by genetic algorithm. The proposed method is tested for different scenarios and accurate results are obtained.
Effects of Propranolol and Its Stereoisomers upon Coronary Vascular Resistance (1967)

Responses of the coronary vascular bed to propranolol and its stereoisomers were studied in dogs anesthetized with allobarbital and urethane. The circumflex coronary artery was cannulated and perfused at a constant rate with blood from a femoral artery, coronary perfusion pressure being monitored as an index of coronary vascular resistance. dl -Propranolol (0.5 mg/kg iv) increased coronary vascular resistance and simultaneously reduced myocardial contractile force, heart rate, and systemic blood pressure. Approximately two thirds of the increase in coronary resistance was associated with the negative chronotropic action of propranolol. Intracoronary injections of dl -propranolol and l -propranolol increased coronary vascular resistance; d -propranolol increased resistance after an initial transient coronary dilatation. Intracoronary injections reduced contractile force in the pump-perfused area, but were without effects on heart rate and blood pressure. Reserpine pretreatment reduced, but did not abolish, the coronary vascular response to systemic propranolol; the chronotropic and inotropic responses were abolished. The responses to intracoronary d -propranolol were not altered. It was concluded that the increase in coronary vascular resistance following propranolol is due largely to the negative chronotropic effect of the drug and to an action of the drug which is unrelated to specific β-adrenergic receptor blockade.
Deletion of <i>lolB</i> , Encoding an Outer Membrane Lipoprotein, Is Lethal for <i>Escherichia coli</i> and Causes Accumulation of Lipoprotein Localization Intermediates in the Periplasm (2001)

Outer membrane lipoproteins of Escherichia coli are released from the inner membrane upon the formation of a complex with a periplasmic chaperone, LolA, followed by localization to the outer membrane. In vitro biochemical analyses revealed that the localization of lipoproteins to the outer membrane generally requires an outer membrane lipoprotein, LolB, and occurs via transient formation of a LolB-lipoprotein complex. On the other hand, a mutant carrying the chromosomal lolB gene under the control of the lac promoter-operator grew normally in the absence of LolB induction if the mutant did not possess the major outer membrane lipoprotein Lpp, suggesting that LolB is only important for the localization of Lpp in vivo. To examine the in vivo function of LolB, we constructed a chromosomal lolB null mutant harboring a temperature-sensitive helper plasmid carrying the lolB gene. At a nonpermissive temperature, depletion of the LolB protein due to loss of the lolB gene caused cessation of growth and a decrease in the number of viable cells irrespective of the presence or absence of Lpp. LolB-depleted cells accumulated the LolA-lipoprotein complex in the periplasm and the mature form of lipoproteins in the inner membrane. Taken together, these results indicate that LolB is the first example of an essential lipoprotein for E. coli and that its depletion inhibits the upstream reactions of lipoprotein trafficking.
Effects of Rearing Diet, Age at Freshening, and Lactation Feeding System on Performance (1991)

This two-phase trial involved 83 Holstein heifers. The rearing phase consisted of two diets (alfalfa silage plus corn grain for ad libitum intake vs. corn silage plus urea for ad libitum intake) and two breeding age groups (13 vs. 16 mo). The lactation phase compared the above treatments plus two lactation feeding systems: concentrate fed individually to production versus a TMR. The heifers were assigned randomly to the rearing phase at 7 wk of age and fed their respective diets until 14 d prepartum. They were placed on preassigned lactation diets 14 d prepartum and remained on the lactation phase for 550 consecutive d. Daily gains and height at the withers were similar between forage groups during the first half of the rearing phase; in the second half, the heifers fed alfalfa silage were taller at the withers. Those fed corn silage consumed less DM and CP throughout the rearing phase and gained more BW than the heifers fed alfalfa in the latter half. There were no differences in daily gain or DMI between the breeding age groups. In the lactation phase, the group fed alfalfa for ad libitum intake consumed more DM and gave more milk during the first 90 d of lactation than heifers fed corn silage. However, after 90 d the difference in cumulative milk production was not significant. There were no differences in milk production. FCM, or DMI between breeding age groups. The cows fed concentrate consumed more DM and gave more milk during the first 90 d of lactation. By 550 d, there were no differences. Feeding high levels of corn silage can cause heifers to have lower DMI in early lactation. These differences tend to disappear during the second lactation.
Therapy of vector-borne protozoan infections in nonendemic settings (2011)

Vector-borne protozoan infections are responsible for a wide variety of illnesses (mainly malaria, trypanosomiasis and leishmaniasis) affecting tropical and subtropical areas, but increasingly diagnosed in nonendemic settings. This article summarizes the therapeutic developments for these conditions during the past decade and focuses specifically on treatment recommendations for returning travelers and migrants. The treatment of malaria has known the most spectacular improvements. Progress in the management of leishmaniasis and trypanosomiasis has also been substantial and includes introduction of new drugs into clinical practice, combinations of existing drugs, or new laboratory tools for treatment monitoring as well as extension of treatment indications to new groups of patients. Serious gaps still exist in terms of effectiveness and tolerance. Since the research pipeline is very limited for the coming 5-10 years, optimized combinations of existing drugs need to be urgently explored.
Is National Treatment Still Viable? U.S. Policy in Theory and Practice (1990)

National treatment, which precludes the use of rules that discriminate between foreign and domestic firms, seeks to ensure equality of competitive opportunity for foreign firms entering or operating in a host country. National treatment is a generally accepted principle for international trade in financial services. It is the basis for commitments by the twenty-four countries belonging to the Organization for Economic Cooperation and Development (OECD) and for the current negotiations on trade in services in the Uruguay Round of the General Agreement on Tariffs and Trade (GATT). This paper provides an analysis of national treatment and alternative principles in the context of the banking sector, with the U.S. experience as an example.The first section of the paper presents a conceptual analysis of national treatment and of principles that go beyond national treatment that have been used or proposed to govern domestic market access for foreign firms. The second section discusses the development and application of the U.S. policy of national treatment in the context of the conflicting demands created by the internationalization of banking and a host-country regulatory structure that differs significantly from that of other major industrial countries. The treatment of nonbanking activities and interstate activities of foreign banks that operate banking offices in the United States are used as examples of the U.S. approach. The final section presents the conclusions.
A device for rapid and quantitative measurement of cardiac myocyte contractility (2015)

Cardiac contractility is the hallmark of cardiac function and is a predictor of healthy or diseased cardiac muscle. Despite advancements over the last two decades, the techniques and tools available to cardiovascular scientists are limited in their utility to accurately and reliably measure the amplitude and frequency of cardiomyocyte contractions. Isometric force measurements in the past have entailed cumbersome attachment of isolated and permeabilized cardiomyocytes to a force transducer followed by measurements of sarcomere lengths under conditions of submaximal and maximal Ca(2+) activation. These techniques have the inherent disadvantages of being labor intensive and costly. We have engineered a micro-machined cantilever sensor with an embedded deflection-sensing element that, in preliminary experiments, has demonstrated to reliably measure cardiac cell contractions in real-time. Here, we describe this new bioengineering tool with applicability in the cardiovascular research field to effectively and reliably measure cardiac cell contractility in a quantitative manner. We measured contractility in both primary neonatal rat heart cardiomyocyte monolayers that demonstrated a beat frequency of 3 Hz as well as human embryonic stem cell-derived cardiomyocytes with a contractile frequency of about 1 Hz. We also employed the β-adrenergic agonist isoproterenol (100 nmol l(-1)) and observed that our cantilever demonstrated high sensitivity in detecting subtle changes in both chronotropic and inotropic responses of monolayers. This report describes the utility of our micro-device in both basic cardiovascular research as well as in small molecule drug discovery to monitor cardiac cell contractions.
<title>Recent advances in heavy-metal oxide glass research</title> (1990)

Our laboratory recently has announced the formation of glasses based on the oxides of lead bismuth and gallium. These glasses are unusual in that they contain none of the traditional glass-forming caflons (eg. silicon boron germanium or phosphorous) yet exhibit a remarkable stability. In addition to this stability these compositions exhibit some rather unique properties such as the ability to transmit well into the infrared region (to about 8 microns) and a high nonresonant optical nonlinearity 3 (of 42 xlO 14 esu). To take advantage of this latter property for optical switching applications it is desirable to prepare the glass as an optical waveguide. Silica additions were made to a heavy metal oxide base glass in an effort to derive compositions suitable for core and cladding. The present paper describes the effects of these additions. 1.
Graduated compression stockings (2014)

Compression therapy is a frequently used physical therapy in conditions involving venous and lymphatic insufficiency in the lower limbs, including varicosities, lymphedema, venous eczema and ulceration, deep vein thrombosis and postthrombotic syndrome. The many forms of compression therapy include
Facilitating the online search of experts at NASA using expert seeker people-finder (2000)

People-Finder Systems are knowledge repositories that attempt to manage knowledge by holding pointers to experts who possess specific knowledge within an organization. This paper presents insights from the development of Expert Seeker, an organizational People-Finder KMS that will be used to locate experts at the National Aeronautics and Space Administration (NASA). This paper discusses insights and lessons learned from the development of this system, and the role of technology in automating the maintenance of the expert&apos;s profiles. Expert Seeker represents an important first step towards achieving our objective of automatically and intuitively discovering and identifying intellectual capital within the organization. While several systems in place today rely on self-assessment, we look at the potential of artificial intelligence (AI) technologies, in particular, data mining and clustering techniques, to uncover and map organizational expertise. 1
Triple-shape properties of a thermoresponsive poly(ester urethane) (2009)

Thermo-mechanical investigations on a segmented poly(ester urethane) have shown that the material displays triple-shape functionality: gradual heating of programmed specimens leads first to the transformation from shape (A) to shape (B) and later from shape (B) back to permanent shape (C). In the essential two-step programming process, the first deformation state (B) is stabilized by crystallized soft segments at T<Tc, the second one (A) through the polymer's glassy state at T<Tg. The transition temperatures, as analyzed for the permanent-shaped polymer via DSC, are Tg≈−49 °C and Tm(onset)≈34 °C; the material crystallizes when cooled at Tc(onset)≈4 °C. For the characterization of the material's cyclic thermo-mechanical triple-shape properties, maximum deformations of εm1 = 100% for shape (B) and εm2 = 130% for shape (A) were tested. In cycles N = 2–5 averaged shape fixing abilities of 74% (shape A, −60 °C), 109% (shape B, 23 °C) and shape recoverabilities of 103% (A B) and 96% (B C) could be detected. Values larger than 100% indicate the occurrence of plastic deformation during the second stretching.
THE EFFECT OF HIGH PRESSURE ON CRYSTALLIZATION KINETICS: FUSED SILICA. (1966)

Abstract : A thermodynamic theory is developed for the effect of pressure on the kinetics of phase transformations. The results suggest that application of pressure may have a profound effect in increasing the rate of crystal nucleation, but that its effect on growth rate should generally be a smaller inhibitory one. Observations on SiO2 carried out in a Bridgman-anvil high pressure device demonstrated the occurrence of crystallization under conditions of temperature and pressure where none had been anticipated from the kinetic formalism. A number of hypotheses are suggested to account for the observations, the most satisfactory of which is based on the effect of water, and the possible existence of a water-rich region at the interface at high pressure, in enhancing the extent of crystallization in a given time. (Author)
Functional Characterization of the Promoter Region of the Platelet-activating Factor Receptor Gene. (1995)

To understand the molecular mechanisms that direct the expression of the gene encoding the platelet-activating factor (PAF) receptor, the 5'-flanking region of the human PAF receptor gene was cloned, and its promoter activity in myeloid cell lines was characterized. By the 5'-rapid amplification of cDNA ends method and primer extension, the transcription initiation site was mapped to an adenosine residue 137 bases upstream of the ATG translation initiation codon. The promoter region lacks a typical TATA or CCAAT box. However, the sequence encompassing the transcription initiation site shows high homology to the initiator (Inr) sequence. Transfection of promonocytic U937 cells with recombinant plasmids containing a series of truncated segments of the 5'-flanking region linked to the luciferase reporter gene revealed that the sequence from nucleotides -44 to +27 relative to the transcription initiation site was sufficient to promote a high level of gene expression. The promoter activity was much lower in nonexpressing HeLa cells and promyelocytic HL-60 cells, which express relatively low levels of the PAF receptor. Gel mobility shift analysis demonstrated the binding of nuclear factors extracted from myelocytic cells to the -16/+18 sequence containing the Inr element. No binding activity was detected using the nuclear extracts from the nonmyelocytic HeLa cells. The DNA-protein complexes were sequence-specific since the binding was not significantly affected by the mutated Inr sequences or the Inr sequence of the terminal deoxynucleotidyltransferase gene. Furthermore, point mutations in the Inr element significantly reduced promoter activity in both U937 and THP-1 cell lines. When Me2SO or retinoic acid was used to induce granulocytic differentiation of HL-60 cells, a distinct Inr-protein complex was induced concurrently, but the complex was not observed in 12-O-tetradecanoylphorbol-13-acetate-induced monocytic differentiated HL-60 cells or Me2SO-induced differentiated U937 cells, indicating that the inducible Inr binding activity is granulocyte-specific. These results suggest that distinct nuclear factors interact with the unique Inr element and play a role in the transcriptional regulation of the PAF receptor in various myeloid cells.
4H–SiC Metal–Semiconductor–Metal Ultraviolet Photodetectors in Operation of 450 $^{\circ}\hbox{C}$ (2012)

This work demonstrates the high-temperature operation of metal-semiconductor-metal (MSM) photodetectors (PDs) up to 450 °C using lightly Al-doped epitaxial 4H-SiC thin films. The responsivity of the PDs under 325-nm illumination is 0.0305 A/W at 20-V bias at room temperature. The photocurrentto-dark-current ratio of the SiC MSM PDs is as high as 1.3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> at 25 °C and is 0.62 at 450 °C. The rise/fall time of the PDs is increased slightly from 594 μs/684 μs to 684 μs/786 μs as the temperature increases from room temperature to 400 °C. These results support the use of 4H-SiC PDs in extremely high temperature applications.
Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication (2019)

To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency virus (SIV) Vpx proteins, the direct viral countermeasures against SAMHD1 restriction remain unknown. Using Epstein-Barr virus (EBV) as a primary model, we discover that SAMHD1-mediated anti-viral restriction is antagonized by EBV BGLF4, a member of the conserved viral protein kinases encoded by all herpesviruses. Mechanistically, we find that BGLF4 phosphorylates SAMHD1 and thereby inhibits its deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity. We further demonstrate that the targeting of SAMHD1 for phosphorylation is a common feature shared by beta- and gamma-herpesviruses. Together, our findings uncover an immune evasion mechanism whereby herpesviruses exploit the phosphorylation of SAMHD1 to thwart host defenses.
Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis (2010)

Recognition of FBDS should prompt testing for VGKC-complex/Lgi1 antibodies. AEDs often produce adverse effects; treatment with immunotherapies may prevent the development of LE with its potential for cerebral atrophy and cognitive impairment.
What Makes Training Multi-Modal Classification Networks Hard? (2019)

Consider end-to-end training of a multi-modal vs. a single-modal network on a task with multiple input modalities: the multi-modal network receives more information, so it should match or outperform its single-modal counterpart. In our experiments, however, we observe the opposite: the best single-modal network always outperforms the multi-modal network. This observation is consistent across different combinations of modalities and on different tasks and benchmarks. This paper identifies two main causes for this performance drop: first, multi-modal networks are often prone to overfitting due to increased capacity. Second, different modalities overfit and generalize at different rates, so training them jointly with a single optimization strategy is sub-optimal. We address these two problems with a technique we call Gradient Blending, which computes an optimal blend of modalities based on their overfitting behavior. We demonstrate that Gradient Blending outperforms widely-used baselines for avoiding overfitting and achieves state-of-the-art accuracy on various tasks including human action recognition, ego-centric action recognition, and acoustic event detection.
Ozonized Low Density Lipoprotein (ozLDL) Inhibits NF-κB and IRAK-1–Associated Signaling (2006)

Our study demonstrated that ozLDL inhibited NF-kappaB and IRAK-1-associated signaling which may impair immune function and promote apoptosis.