gebhart/patrepeval huggingface dataset:
Immunohistochemical Localization of Collagen Type XI α1 and α2 Chains in Human Colon Tissue (2007)

In previous studies, collagen XI mRNA has been detected in colon cancer, but its location in human colon tissue has not been determined. The heterotrimeric collagen XI consists of three alpha chains. While it is known that collagen XI plays a regulatory role in collagen fibril formation, its function in the colon is unknown. The characterization of normal human colon tissue will allow a better understanding of the variance of collagen XI in abnormal tissues. Grossly normal and malignant human colon tissue was obtained from pathology archives. Immunohistochemical staining with a 58K Golgi marker and alpha1(XI) and alpha2(XI) antisera was used to specifically locate their presence in normal colon tissue. A comparative bright field microscopic analysis showed the presence of collagen XI in human colon. The juxtanuclear, dot-like collagen XI staining in the Golgi apparatus of goblet cells in normal tissue paralleled the staining of the 58K Golgi marker. Ultra light microscopy verified these results. Staining was also confirmed in malignant colon tissue. This study is the first to show that collagen XI is present in the Golgi apparatus of normal human colon goblet cells and localizes collagen XI in both normal and malignant tissue. Although the function of collagen XI in the colon is unknown, our immunohistochemical characterization provides the foundation for future immunohistopathology studies of the colon.
Synchronizable error-control coding for railway track circuit data transmission (1987)

Digital transmission of cab signalling and train control data to moving traing using railway track circuits may be achieved with FSK modulation of an audio frequency carrier signal. By transmitting coded data, information concerning train location and system status may be carried in addition to safety commands such as target speeds. The distributed nature of railway control systems using track circuits for train detection and track-train data transmission requires the use of coding schemes that tolerate sudden discontinuities at track circuit boundaries in addition to being able to operate in a high noise environment. With audio frequency jointless track circuits, severe constraints are imposed on the transmission frequencies by the characteristics of the electrical separation joint, resulting in low data rates. The paper describes several coding schemes that may be used to overcome the resulting synchronization and error-control problems.
Fast Channel Establishment for IEEE 802.16 Wireless Mesh Networks (2010)

IEEE 802.16 based wireless mesh networks (WMNs) are a promising broadband access solution to support flexibility, cost effectiveness and fast deployment of the fourth generation infrastructure based wireless networks. Reducing the time for channel establishment is critical for low latency/interactive applications. In this paper, we propose two modifications to the election based transmission timing (EBTT) mechanism used in the coordinated distributed scheduling (CDS) within the IEEE 802.16 standard, which makes use of the standardized signaling messages and formats. Simulation results show that our proposed modifications results in significantly reduced channel establishment delay - up to 75% with low neighborhood densities - over the standard, and at least 10% with high neighborhood densities. Moreover, the proposed mechanisms are also applicable for the three-hop extended neighborhood CDS when required.
Enantioselective Synthesis of α-Hydroxy and α-Amino Phosphonates via Catalytic Asymmetric Hydrogenation (1999)

Cationic rhodium catalysts of the C2 symmetric DuPHOS (1) and BPE (2) ligands have demonstrated the ability to asymmetrically hydrogenate a novel series of enol phosphonates (3) in good to excellent enantiomeric excess under mild conditions. Initial studies toward the catalytic asymmetric hydrogenation of enamido phosphonates (6 and 7) using the DuPHOS−Rh+ catalysts are also reported.
A Randomized Algorithm for Closest-Point Queries (1988)

An algorithm for closest-point queries is given. The problem is this: given a set S of n points in d-dimensional space, build a data structure so that given an arbitrary query point p, a closest point in S to p can be found quickly. The measure of distance is the Euclidean norm. This is sometimes called the post-office problem. The new data structure will be termed an RPO tree, from Randomized Post Office. The expected time required to build an RPO tree is $O(n^{\lceil {{d / 2}} \rceil (1 + \epsilon )} )$, for any fixed $\epsilon > 0$, and a query can be answered in $O(\log n)$ worst-case time. An RPO tree requires $O(n^{\lceil {{d / 2}} \rceil (1 + \epsilon )} )$ space in the worst case. The constant factors in these bounds depend on d and $\epsilon $. The bounds are average-case due to the randomization employed by the algorithm, and hold for any set of input points. This result approaches the $\Omega (n^{\lceil {{d / 2}} \rceil } )$ worst-case time required for any algorithm that constructs the Voronoi diagram of the input points, and is a considerable improvement over previous bounds for $d > 3$. The main step of the construction algorithm is the determination of the Voronoi diagram of a random sample of the sites, and the triangulation of that diagram.
Sur la Russie (1967)

Blanc Simone. Sur la Russie. In: Annales. Economies, sociétés, civilisations. 22ᵉ année, N. 6, 1967. pp. 1344-1349.
A 0.04 mm Buck-Boost DC-DC Converter for Biomedical Implants Using Adaptive Gain and Discrete Frequency Scaling Control (2015)

This paper presents the design of a reconfigurable buck-boost switched-capacitor DC-DC converter suitable for use in a wide range of biomedical implants. The proposed converter has an extremely small footprint and uses a novel control method that allows coarse and fine control of the output voltage. The converter uses adaptive gain control, discrete frequency scaling and pulse-skipping schemes to regulate the power delivered to a range of output voltages and loads. Adaptive gain control is used to implement variable switching gain ratios from a reconfigurable power stage and thereby make coarse steps in output voltage. A discrete frequency scaling controller makes discrete changes in switching frequency to vary the power delivered to the load and perform fine tuning when the output voltage is within 10% of the target output voltage. The control architecture is predominately digital and it has been implemented as part of a fully-integrated switched-capacitor converter design using a standard bulk CMOS 0.18 μm process. Measured results show that the converter has an output voltage range of 1.0 to 2.2 V, can deliver up to 7.5 mW of load power and efficiency up to 75% using an active area of only 0.04 mm (2), which is significantly smaller than that of other designs. This low-area, low-complexity reconfigurable power converter can support low-power circuits in biomedical implant applications.
Thieno [3,2-b] pyridine. I. The Preparation and Properties of an S-Isosteric 8-Hydroxyquinoline<sup>1</sup> (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThieno [3,2-b] pyridine. I. The Preparation and Properties of an S-Isosteric 8-Hydroxyquinoline1John T. Sheehan and George J. LeitnerCite this: J. Am. Chem. Soc. 1952, 74, 21, 5501–5503Publication Date (Print):November 1, 1952Publication History Published online1 May 2002Published inissue 1 November 1952https://pubs.acs.org/doi/10.1021/ja01141a082https://doi.org/10.1021/ja01141a082research-articleACS PublicationsRequest reuse permissionsArticle Views142Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heparin and Low-Molecular Weight Heparins in Thrombosis and Beyond (2010)

Heparin and its improved version, low-molecular weight heparin (LMWH), are known to exert polypharmacological effects at various levels. Early studies focused on the plasma anti-Xa and anti-IIa pharmacodynamics of different LMWHs. Other important pharmacodynamic parameters for heparin and LMWH, including effects on vascular tissue factor pathway inhibitor (TFPI) release, inhibition of inflammation through NFkappaB, inhibition of key matrix-degrading enzymes, selectin modulation, inhibition of platelet-cancer cell interactions, and inflammatory cell adhesion, help explain the diverse clinical impact of this class of agents in thrombosis and beyond.
FK 482, a new orally active cephalosporin. Synthesis and biological properties. (1988)

Recently, we have reported the synthesis and biological properties of a new orally absorbable cephem, cefixime (CFIX, la) and the related compounds1~4). CFIX is the first orally active cephem having an aminothiazolyl side chain in the 7-position like newer parenteral cephalosporins such as ceftizoxime and has a broad spectrum of antibacterial activity and a high stability against various /3-lactamases. However, CFIX shows only low to moderate antibacterial activity against a few Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis. In the course of our
Behavior of the Posterior Semicircular Canal after Dix-Hallpike Maneuver (2016)

The objective of the present study is to analyze the quantitative vestibulo-ocular responses in a group of patients with benign paroxysmal positional vertigo (BPPV) canalolithiasis and compare these data with the data of the tridimensional biomechanical model. This study was conducted on 70 patients that presented idiopathic posterior semicircular canal canalolithiasis. The diagnosis was obtained by Dix-Hallpike maneuvers recorded by videonystagmograph. The present study demonstrates that there is a significant correlation between the intensity of the nystagmus and its latency in cases of BPPV-idiopathic posterior semicircular canal canalolithiasis type. These findings are in agreement with those obtained in a tridimensional biomechanical model and are not related to the patients' age.
Perovskite Solar Cells: From Materials to Devices (2014)

Perovskite solar cells based on organometal halide light absorbers have been considered a promising photovoltaic technology due to their superb power conversion efficiency (PCE) along with very low material costs. Since the first report on a long-term durable solid-state perovskite solar cell with a PCE of 9.7% in 2012, a PCE as high as 19.3% was demonstrated in 2014, and a certified PCE of 17.9% was shown in 2014. Such a high photovoltaic performance is attributed to optically high absorption characteristics and balanced charge transport properties with long diffusion lengths. Nevertheless, there are lots of puzzles to unravel the basis for such high photovoltaic performances. The working principle of perovskite solar cells has not been well established by far, which is the most important thing for understanding perovksite solar cells. In this review, basic fundamentals of perovskite materials including opto-electronic and dielectric properties are described to give a better understanding and insight into high-performing perovskite solar cells. In addition, various fabrication techniques and device structures are described toward the further improvement of perovskite solar cells.
Mining the Minds of Customers from Online Chat Logs (2015)

This study investigates factors that may determine satisfaction in customer service operations. We utilized more than 170,000 online chat sessions between customers and agents to identify characteristics of chat sessions that incurred dissatisfying experience. Quantitative data analysis suggests that sentiments or moods conveyed in online conversation are the most predictive factor of perceived satisfaction. Conversely, other session related meta data (such as that length, time of day, and response time) has a weaker correlation with user satisfaction. Knowing in advance what can predict satisfaction allows customer service staffs to identify potential weaknesses and improve the quality of service for better customer experience.
Metabolism of arginine and its positive effect on growth and revival of<i>Oenococcus oeni</i> (2000)

Oenococcus oeni is the main lactic acid bacteria species which induces malolactic fermentation during wine-making. It is able to break down arginine via the arginine deiminase pathway, a potential source of energy already considered for many bacteria. The production of ATP by starved cells from arginine was quantified with a bioluminescence assay, and efficient coupling of amino acid catabolism and cell growth was monitored. Therefore, molecular growth yield was determined after glucose exhaustion. With colony plate counting and a direct epifluorescence technique, it was shown that addition of arginine to viable but non-culturable cells obtained after nutrient starvation restored their ability to grow during its degradation. Therefore, arginine produced more than maintenance energy. It is concluded that strains which are able to metabolize arginine might take advantage of this additional energy source for growth.
Anti-Idiotype Monoclonal Antibodies as Vaccines for Human Cancer (1991)

The anti-idiotype therapy approach has been tested and has shown to be effective in several animal models including the L1210/GZL tumor system in DBA/2 mice. Very recently, anti-idiotype antibodies (Ab2) have also been used in human trials. In this review, the generation and characterization of Ab2s which can be used as potential vaccine candidates for two human tumor systems--leukemia/lymphona and gastrointestinal carcinoma have been discussed. We have generated syngeneic monoclonal idiotypic cascades for two different human tumor-associated antigens (TAA) gp37 and carcinoembryonic antigen (CEA). In both cascades we have produced TAA mimicking monoclonal Ab2s and monoclonal anti-anti-idiotypes (Ab3) which bind to the original TAA. Modulation of immune responses in cancer patients by Ab2 immunization will be an important consideration in future studies.
Diesel Exhaust Particle Size: Measurement Issues and Trends (1998)

<div class="htmlview paragraph">Exhaust particle number concentrations and size distributions were measured from the exhaust of a 1995 direct injection, Diesel engine. Number concentrations ranged from 1 to 7.5×10<sup>7</sup> particles/cm<sup>3</sup>. The number size distributions were bimodal and log-normal in form with a nuclei mode in the 7-15 nm diameter range and an accumulation mode in the 30-40 nm range. For nearly all operating conditions, more than 50% of the particle number, but less than 1% of the particle mass were found in the nuclei mode. Preliminary indications are that the nuclei mode particles are solid and formed from volatilization and subsequent nucleation of metallic ash from lubricating oil additives. Modern low emission engines produce low concentrations of soot agglomerates. The absence of these agglomerates to act as sites for adsorption or condensation of volatile materials makes nucleation and high number emissions more likely. In the case of the engine and dilution system tested here the volatile materials are ash, in other cases they may be SOF or sulfuric acid. The dilution and sampling system used in these experiments was designed to give very fast dilution of the exhaust with dry air. Conventional dilution tunnel systems have much slower dilution processes making more time available for nucleation and growth. Thus it is likely that if this engine were tested in such a system, more volatile materials would be present in the nuclei mode and its mass, and possibly number, concentrations would be greater.</div>
Determination of steroids in biological samples by micellar electrokinetic chromatography (2007)

The possibility of determining eight adrenocorticotropic steroid hormones (cortisol, cortisone, corticosterone, 11-dehydrocorticosterone, 17-hydroxyprogesterone, 11-deoxycortisol, and progesterone) by micellar electrokinetic chromatography (MEKC) using urea as an organic additive to the working electrolyte (a 25 mM phosphoric acid solution and 10 mM sodium dodecyl sulfate) was demonstrated. The use of online preconcentration (stacking and sweeping) allowed us to lower the detection limit for steroids to ∼3 ng/mL. The total analysis time was 15 min.
Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1–42) compared to Aβ(1–40) (2017)

Intraneuronal accumulation of amyloid-β (Aβ) peptides represent an early pathological feature in Alzheimer's disease. We have therefore utilized flow cytometry and confocal microscopy in combination with endocytosis inhibition to explore the internalisation efficiency and uptake mechanisms of Aβ(1-40) and Aβ(1-42) monomers in cultured SH-SY5Y cells. We find that both variants are constitutively internalised via endocytosis and that their uptake is proportional to cellular endocytic rate. Moreover, SH-SY5Y cells internalise consistently twice the amount of Aβ(1-42) compared to Aβ(1-40); an imaging-based quantification showed that cells treated with 1 µM peptide for 8 h contained 800,000 peptides of Aβ(1-42) and 400,000 of Aβ(1-40). Both variants co-localised to >90% with lysosomes or other acidic compartments. Dynasore and chlorpromazine endocytosis inhibitors were both found to reduce uptake, particularly of Aβ(1-42). Overexpression of the C-terminal of the clathrin-binding domain of AP180, dynamin2 K44A, or Arf6 Q67L did however not reduce uptake of the Aβ variants. By contrast, perturbation of actin polymerisation and inhibition of macropinocytosis reduced Aβ(1-40) and Aβ(1-42) uptake considerably. This study clarifies mechanisms of Aβ(1-40) and Aβ(1-42) uptake, pinpoints differences between the two variants and highlights a common and putative role of macropinocytosis in the early accumulation of intraneuronal Aβ in AD.
Reactions of aryl isocyanates with substituted formamides and formamidines (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of aryl isocyanates with substituted formamides and formamidinesElizabeth Dyer, Theodore E. Majewski, and John D. TravisCite this: J. Org. Chem. 1968, 33, 10, 3931–3932Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://doi.org/10.1021/jo01274a051Request reuse permissionsArticle Views86Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (269 KB) Get e-Alertsclose Get e-Alerts
RODENT MODELS OF ALCOHOLISM: A REVIEW (1989)

Four criteria should be fulfilled when establishing an animal model of alcoholism. (1) The animal should voluntarily and selectively consume a solution of the drug to yield pharmacologically significant blood alcohol concentrations. When ethanol is consumed for several weeks under these conditions, (2) the animals should exhibit tolerance to the acute effects of the drug. Furthermore, (3) abrupt termination of drug administration should result in physical signs of drug withdrawal (e.g. audiogenic seizures). (4) Changes in endocrine and liver function would also be expected to occur following the chronic administration of alcohol, such effects being particularly pronounced if the diet of the animal is nutritionally deficient. A number of self-administration, operant conditioning and forced alcohol administration models are critically assessed. A detailed description of the models in which rodents are forced to consume increasing quantities of alcohol as part of a nutritionally enriched milk diet suggests that this method fulfils most of the above criteria.
Surface Studies by Optical Second-Harmonic Generation: The Adsorption of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>, CO, and Sodium on the Rh(111) Surface (1984)

Optical second-harmonic generation is used to study the adsorption of atomic and diatomic species on a well characterized Rh(111) crystal surface in ultrahigh vacuum. The results correlate well with those obtained by other surface probes.
Vadose Zone Remediation of Carbon Dioxide Leakage from Geologic Carbon Dioxide Sequestration Sites (2004)

In the unlikely event that CO 2 leakage from deep geologic CO 2 sequestration sites reaches the vadose zone, remediation measures for removing the CO 2 gas plume may have to be undertaken. Carbon dioxide leakage plumes are similar in many ways to volatile organic compound (VOC) vapor plumes, and the same remediation approaches are applicable. We present here numerical simulation results of passive and active remediation strategies for CO 2 leakage plumes in the vadose zone. The starting time for the remediation scenarios is assumed to be after a steady‐state CO 2 leakage plume is established in the vadose zone, and the source of this plume has been cut off. We consider first passive remediation, both with and without barometric pumping. Next, we consider active methods involving extraction wells in both vertical and horizontal configurations. To compare the effectiveness of the various remediation strategies, we define a half‐life of the CO 2 plume as a convenient measure of the CO 2 removal rate. For CO 2 removal by passive remediation approaches such as barometric pumping, thicker vadose zones generally require longer remediation times. However, for the case of a thin vadose zone where a significant fraction of the CO 2 plume mass resides within the high liquid saturation region near the water table, the half‐life of the CO 2 plume without barometric pumping is longer than for somewhat thicker vadose zones. As for active strategies, results show that a combination of horizontal and vertical wells is the most effective among the strategies investigated, as the performance of commonly used multiple vertical wells was not investigated.