gebhart/patrepeval huggingface dataset:
Business and Management Challenges for End-To-End Reconfiguration (2005)

Reconfiguration technologies have an increasing role in the evolution of mobile system towards heterogeneous ubiquitous infrastructures. The present contribution initially discusses business model aspects for reconfigurable systems and services. Furthermore, it elaborates on advanced reconfigurability functionality, in the form of an innovative Reconfigurability Management Plane, which addresses the coordination of the end-to-end reconfiguration process in next generation wireless networks.
Generation of a unique fibroblast-activating factor by human monocytes. (1984)

Purified human monocytes incubated with phytohemagglutinin (PHA), bacterial lipopolysaccharide (LPS), or serum-opsonized zymosan particles (OZ) generate human dermal fibroblast-activating activity, as assessed by increased fibroblast incorporation of [3H]-thymidine. A maximum concentration of fibroblast-activating activity was attained within 4 hr with OZ, whereas similar maximum levels required 12 hr with LPS and PHA. Sonicates of unstimulated monocytes had only minimal activity and the protein synthesis inhibitor cycloheximide suppressed significantly the appearance of fibroblast-activating activity, suggesting that the factors are generated prior to release. Filtration of supernates from OZ-stimulated monocytes on Sephadex G-75 yielded polydisperse fibroblast-activating activities, of which the major factors exhibited a mol. wt. of approximately 60,000 and 10,000. The supernates from PHA-stimulated monocytes had one predominant factor, termed fibroblast-activating factor of monocytes (FAF-M), with an apparent mol. wt. of 38,000 and a minor activity with a mol. wt. of 10,000. FAF-M was composed of two principles with isoelectric points of 5.1-5.2 and 4.0-4.2 and was free of interleukin-1, as determined by the absence of thymocyte-activating activity. FAF-M and other fibroblast-activating factors may contribute to wound healing and fibrosis in lesions characterized by mononuclear phagocyte infiltrates.
Reduction of respiratory motion artifacts for free-breathing whole-heart coronary MRA by weighted iterative reconstruction (2014)

Self-navigated coronary magnetic resonance angiography was successfully combined with weighted iterative reconstruction to reduce the total acquisition time and efficiently suppress respiratory motion artifacts. The simplicity of the experimental setup and the promising image quality are encouraging toward future clinical evaluation.
Three Confinement Systems—Spherical Tokamak, Standard Tokamak, and Stellarator: A Comparison of Key Component Cost Elements (2018)

Since the 1950s “next-step” fusion devices and power plant studies have been developed for a number of magnetic confinement systems but an open question remains: can a magnetic fusion device be simplified to the point where it will be cost competitive and operate with high availability? Concept designs based on the ARIES advanced tokamak, spherical tokamak (ST), and the quasi-axisymmetric (QAS) stellarator option have progressed in recent years through a series of Princeton Plasma Physics Laboratory (PPPL) studies with an underlying intent to improve the engineering feasibility of each, giving special attention to concepts that simplify the device configuration and improve maintenance features. For the ST option, design details centered on a 3-m Fusion Nuclear Science Facility that evolved to incorporate vertical maintenance, high temperature superconductor magnets, a small inboard duel coolant lead lithium blanket, and a liquid metal divertor. In collaboration with the Korean fusion demonstration reactor (K-DEMO) and CFETR concept study teams the tokamak design has evolved to increase plasma component access within a vertical maintenance approach using enlarged toroidal field coils incorporating a low- and high-field Nb3Sn winding pack that provide a peak field of 16 T. A recent PPPL stellarator study focused on simplifying the stellarator winding topology to improve access to in-vessel components; combining coil optimization with winding surfaces that incorporated geometry constraints specified by engineering. This paper centered on a 1000-MW power plant design with a tokamak like vertical maintenance scheme that allows access to remove large internal blanket sectors. Results of three confinement studies (PPPL developed ST, K-DEMO, and QAS stellarator) will be presented to highlight concepts that simplify each device configuration and improved their maintenance features. Scaling each option to a common 1000-MW net electric power plant mission allows comparisons to be made of key cost elements such as the size of major core components, sizing of the reactor hall, or external facilities needed to handle and store activated in-vessel components.
Verified Models and Reference Implementations for the TLS 1.3 Standard Candidate (2017)

TLS 1.3 is the next version of the Transport Layer Security (TLS) protocol. Its clean-slate design is a reaction both to the increasing demand for low-latency HTTPS connections and to a series of recent high-profile attacks on TLS. The hope is that a fresh protocol with modern cryptography will prevent legacy problems, the danger is that it will expose new kinds of attacks, or reintroduce old flaws that were fixed in previous versions of TLS. After 18 drafts, the protocol is nearing completion, and the working group has appealed to researchers to analyze the protocol before publication. This paper responds by presenting a comprehensive analysis of the TLS 1.3 Draft-18 protocol. We seek to answer three questions that have not been fully addressed in previous work on TLS 1.3: (1) Does TLS 1.3 prevent well-known attacks on TLS 1.2, such as Logjam or the Triple Handshake, even if it is run in parallel with TLS 1.2? (2) Can we mechanically verify the computational security of TLS 1.3 under standard (strong) assumptions on its cryptographic primitives? (3) How can we extend the guarantees of the TLS 1.3 protocol to the details of its implementations? To answer these questions, we propose a methodology for developing verified symbolic and computational models of TLS 1.3 hand-in-hand with a high-assurance reference implementation of the protocol. We present symbolic ProVerif models for various intermediate versions of TLS 1.3 and evaluate them against a rich class of attacks to reconstruct both known and previously unpublished vulnerabilities that influenced the current design of the protocol. We present a computational CryptoVerif model for TLS 1.3 Draft-18 and prove its security. We present RefTLS, an interoperable implementation of TLS 1.0-1.3 and automatically analyze its protocol core by extracting a ProVerif model from its typed JavaScript code.
Progress with, and prospects for, metal complexes in cell imaging (2013)

This article summarises the state of the art of metal complexes in cell imaging, particularly fluorescence microscopy, and presents prospects for the future development of this area. This article combines discussion of, and examples from, both the d- and f-block which have traditionally been considered separately, presenting the important classes of agents in each case, with a general description of their photophysical and cellular behaviour, and comparing and contrasting their properties and applications.
Induction of CTL and Nonpolarized Th Cell Responses by CD8α+ and CD8α− Dendritic Cells (2001)

Two distinct dendritic cell (DC) subpopulations have been evidenced in mice on the basis of their differential CD8alpha expression and their localization in lymphoid organs. Several reports suggest that CD8alpha(+) and CD8alpha(-) DC subsets could be functionally different. In this study, using a panel of MHC class I- and/or class II-restricted peptides, we analyzed CD4(+) and CD8(+) T cell responses obtained after i.v. injection of freshly purified peptide-pulsed DC subsets. First, we showed that both DC subsets efficiently induce specific CTL responses and Th1 cytokine production in the absence of CD4(+) T cell priming. Second, we showed that in vivo activation of CD4(+) T cells by CD8alpha(+) or CD8alpha(-) DC, injected i.v., leads to a nonpolarized Th response with production of both Th1 and Th2 cytokines. The CD8alpha(-) subset induced a higher production of Th2 cytokines such as IL-4 and IL-10 than the CD8alpha(+) subset. However, IL-5 was produced by CD4(+) T cells activated by both DC subsets. When both CD4(+) and CD8(+) T cells were primed by DC injected i.v., a similar pattern of cytokines was observed, but, under these conditions, Th1 cytokines were mainly produced by CD8(+) T cells, while Th2 cytokines were produced by CD4(+) T cells. Thus, this study clearly shows that CD4(+) T cell responses do not influence the development of specific CD8(+) T cell cytotoxic responses induced either by CD8alpha(+) or CD8alpha(-) DC subsets.
Group testing and sparse signal recovery (2008)

Traditionally, group testing is a design problem. The goal is to design an optimally efficient set of tests of items such that the test results contain enough information to determine a small subset of items of interest. It has its roots in the statistics community and was originally designed for the selective service during World War II to remove men with syphilis from the draft. It appears in many forms, including coin-weighing problems, experimental designs, and public health. We are interested in both the design of tests and the design of an efficient algorithm that works with the tests to determine the group of interest because many of the same techniques that are useful for designing tests are also used to solve algorithmic problems in compressive sensing, as well as to analyze and recover statistical quantities from streaming data. This article is an expository article, with the purpose of examining the relationship between group testing and compressive sensing, along with their applications and connections to sparse function learning.
Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra. (2001)

The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra Sieb. et Zucc., Myricaceae) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.
Thermal response of integral, multicomponent composite thermal protection systems (1986)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Pharmacotherapy of attention-deficit/hyperactivity disorder in adults. (1998)

A history of childhood attention-deficit/hyperactivity disorder (ADHD) is a mandatory prerequisite for the diagnosis of adult type ADHD, for which no DSM criteria exists. Since the diagnosis must be made retroactively, tentative criteria have been designed to establish the presence of the childhood disorder. In the 1970s, I advanced the hypothesis that "minimal brain dysfunction" (as ADHD was called) might be produced by decreased catecholaminergic function. A total of over 300 ADHD patients have been included in treatment studies, including 224 patients who received stimulants in four double-blind, placebo-controlled trials: three of methylphenidate (N = 176) and one of pemoline (N = 48). An additional 79 patients have been included in open-label trials of pargyline, selegiline, bupropion, levodopa, phenylalanine, and tyrosine. Altogether, these studies have demonstrated the efficacy of methylphenidate, pemoline, and monoamine oxidase-B (MAO-B) inhibitors when administered to adult ADHD patients; a robust response was produced in 60% of the patients. Bupropion and selegiline were effective in the open-label studies and should be systematically evaluated. A long-term study is being conducted with methylphenidate maintenance; patients have been followed for as long as 5 years, and little, if any, drug tolerance has been observed. Treatment of adult patients who have ADHD is symptomatic, not curative, but the combination of medication and psychotherapy may offer life-changing opportunities to individuals who suffer from the disorder.
Eye movements and their role in visual and cognitive processes. (1990)

Preface. 1. The role of visual and cognitive processes in the control of eye movement (E. Kowler). 2. Predictive control of eye movement (M. Pavel). 3. The role of eye movement in the detection of contrast and spatial detail (R.M. Steinman and J.Z. Levinson). 4. Binocular eye movements and the perception of depth (H. Collewijn and C.J. Erkelens). 5. Eye movement and visual localization of objects in space (A.A. Skavenski). 6. The role of eye movements in the perception of motion and shape (H. Wallach). 7. Comparison of perception in the moving and stationary eye (G. Sperling). 8. Eye movements in visual search: cognitive, perceptual and motor control aspects (P. Viviani). 9. Eye movements and reading (J.K. O'Regan). 10. Eye-movement models for arithmetic and reading performance (P. Suppes). Subject index. Imprint: Elsevier Amsterdam
The Role of Human Rights in Setting the Boundaries of Sovereignty and the Autonomy of the EU Legal Order (2017)

Amsterdam Law Forum (ALF) is the student-run 'International Law Journal' of VU University. Every year ALF publishes a winter, spring, and summer issue. The journal consists of three sections; scientific articles, opinion articles, and commentaries. As of this year, ALF also creates a section for inaugural speeches. In addition, ALF hosts a conference in spring with a relevant legal theme, where renowned speakers are invited to share their perspectives. Overall, ALF is a topical journal that provides a platform for established scholars and young academics to share knowledge, opinions and experiences and to make contributions to the international law discourse. Staff, PhD students and master students who have written a very good thesis are invited to submit an article to ALF. What is learned in the cradle is carried to the tomb: we are looking forward to sharing your articles on our website!
Floating-gate devices: they are not just for digital memories any more (2003)

Since the first reported floating-gate structure in 1967, floating-gate transistors have been used widely to store digital information for long periods in structures such as EPROMs and EEPROMs. Recently floating-gate devices have found applications as analog memories, analog and digital circuit elements, and adaptive processing elements. Floating-gate devices have found commerical applications, e.g. ISD, for long-term non-volatile information storage devices for analog applications. The focus of floating-gate devices has been towards fabrication in standard CMOS processes, as opposed to the specialized processes for fabricating digital non-volatile memories. Floating-gate circuits can be designed at any or all of three levels: analog memory elements, capacitive-based circuit elements, and adaptive circuit elements.
Improved Surface Quality in 3D Printing by Optimizing the Printing Direction (2016)

Abstract We present a pipeline of algorithms that decomposes a given polygon model into parts such that each part can be 3D printed with high (outer) surface quality. For this we exploit the fact that most 3D printing technologies have an anisotropic resolution and hence the surface smoothness varies significantly with the orientation of the surface. Our pipeline starts by segmenting the input surface into patches such that their normals can be aligned perpendicularly to the printing direction. A 3D Voronoi diagram is computed such that the intersections of the Voronoi cells with the surface approximate these surface patches. The intersections of the Voronoi cells with the input model's volume then provide an initial decomposition. We further present an algorithm to compute an assembly order for the parts and generate connectors between them. A post processing step further optimizes the seams between segments to improve the visual quality. We run our pipeline on a wide range of 3D models and experimentally evaluate the obtained improvements in terms of numerical, visual, and haptic quality.
User-generated content (UGC) revolution? (2010)

This dissertation concerns the relationship between the liberating potential of an individuals’ use of new media and the various institutional constraints on that. While I aim to explore the emancipatory potential of YouTube, I seek not to lose sight of the cultural, historical and political forces that limit individual use of it. This dissertation examines YouTube from agent, institution and text perspectives, the triangle of media studies. Each perspective illustrates tensions and conflicts between the personal and the public, amateurism and professionalism, narrowcasting and broadcasting, and User-Generated Content (UGC) and ProfessionallyGenerated Content (PGC). Technological development promises the expansion of the human being, the empowerment of individuals and widening opportunities of communication through personalized media. Amateur users take advantage of the convenience and accessibility in YouTube, and consequently they have a chance to deeply engage in the media content production-distributionconsumption-feedback system. With its encouragement of amateur video production, this new medium seems to have the capability to change the nature of media users, from passive audiences to active creators. However, the myth of the active user is inseparable from celebrity culture. Self-expression on the web is often imbued with the fascination with fame, but is not the same as user empowerment. Amateurism in UGC came to be compromised when the line between UGC and PGC started to blur. From a techno futuristic perspective, YouTube seems to make the audience into interactive users, but that interactivity is close to active consumption in the realm of disposable celebrity. The development of mass media always involves a tension between mass communication and interpersonal communication. Historically, YouTube is positioned within the development of
Non-Invasive Monitoring of Metabolites Using Near Infrared Spectroscopy: State of the Art (1996)

Non-invasive instrumentation for metabolite monitoring can be based on near-infrared spectroscopy. The main research emphasis is on the development of glucose assays, which could be used for patient self-monitoring. Some histological and physiological variability during in-vivo measurements with integral tissue probing is discussed. The state of non-invasive monitoring is presented and compared with other competing methodologies. Different techniques have been proposed so far, which include transmission and diffuse reflectance measurements. Other methods employ photoacoustic laser spectroscopy or the measurement of changes in radiation scattering due to variations in glucose concentration. Currently available technology requires further improvements, in particular for the normal and hypoglycemic ranges, if it is to be used for devices for self- and bedside-monitoring or during surgery. The necessary selectivity for reliable glucose concentration prediction may only be gained by multivariate data analysis exploiting information from broad spectral ranges because of overlapping spectral features from several other biocomponents in the body tissue under investigation.
The distributed interoperable object model and its application to large-scale interoperable database systems (1995)

Article Free Access Share on The distributed interoperable object model and its application to large-scale interoperable database systems Authors: Ling Liu Department of Computing Science, University of Alberta, GSB 615, Edmonton, Alberta, T6G 2H1 Canada Department of Computing Science, University of Alberta, GSB 615, Edmonton, Alberta, T6G 2H1 CanadaView Profile , Calton Pu Dept. of Computer Science and Engineering, Oregon Graduate Institute, P. O. Box 91000 Portland, Oregon Dept. of Computer Science and Engineering, Oregon Graduate Institute, P. O. Box 91000 Portland, OregonView Profile Authors Info & Claims CIKM '95: Proceedings of the fourth international conference on Information and knowledge managementDecember 1995 Pages 105–112https://doi.org/10.1145/221270.221340Published:02 December 1995Publication History 19citation382DownloadsMetricsTotal Citations19Total Downloads382Last 12 Months10Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Polyethylenimine-based micro/nanoparticles as vaccine adjuvants (2017)

Vaccines have shown great success in treating and preventing tumors and infections, while adjuvants are always demanded to ensure potent immune responses. Polyethylenimine (PEI), as one of the well-studied cationic polymers, has been used as a transfection reagent for decades. However, increasing evidence has shown that PEI-based particles are also capable of acting as adjuvants. In this paper, we briefly review the physicochemical properties and the broad applications of PEI in different fields, and elaborate on the intracellular processes of PEI-based vaccines. In addition, we sum up the proof of their in vivo and clinical applications. We also highlight some mechanisms proposed for the intrinsic immunoactivation function of PEI, followed by the challenges and future perspectives of the applications of PEI in the vaccines, as well as some strategies to elicit the desirable immune responses.
Signal Processing for Metagenomics: Extracting Information from the Soup (2009)

Traditionally, studies in microbial genomics have focused on single-genomes from cultured species, thereby limiting their focus to the small percentage of species that can be cultured outside their natural environment. Fortunately, recent advances in high-throughput sequencing and computational analyses have ushered in the new field of metagenomics, which aims to decode the genomes of microbes from natural communities without the need for cultivation. Although metagenomic studies have shed a great deal of insight into bacterial diversity and coding capacity, several computational challenges remain due to the massive size and complexity of metagenomic sequence data. Current tools and techniques are reviewed in this paper which address challenges in 1) genomic fragment annotation, 2) phylogenetic reconstruction, 3) functional classification of samples, and 4) interpreting complementary metaproteomics and metametabolomics data. Also surveyed are important applications of metagenomic studies, including microbial forensics and the roles of microbial communities in shaping human health and soil ecology.