gebhart/patrepeval huggingface dataset:
Erratum for Martínez-Florensa et al., “Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis” (2017)

Sepsis still constitutes an unmet clinical need, which could benefit from novel adjunctive strategies to conventional antibiotic therapy. The soluble form of the scavenger-like human CD6 lymphocyte receptor (shCD6) binds to key pathogenic components from Gram-positive and -negative bacteria and shows time- and dose-dependent efficacy in mouse models of monobacterial sepsis. The objective of the present work was to demonstrate the effectiveness of infusing mouse and human sCD6 by different systemic routes, either alone or as adjunctive therapy to gold standard antibiotics, in a lethal model of polymicrobial sepsis. To this end, C57BL/6 mice undergoing high-grade septic shock induced by cecal ligation and puncture (CLP; ≥90% lethality) were infused via the intraperitoneal (i.p.) or intravenous (i.v.) route with shCD6 at different doses and time points, either alone or in combination with imipenem/cilastatin (I/C) at a dose of 33 mg/kg of body weight every 8 h. Significantly reduced mortality and proinflammatory cytokine levels were observed by i.p. infusion of a single shCD6 dose (1.25 mg/kg) 1 h pre- or post-CLP. When using the i.v. route, mice survival was significantly extended by starting shCD6 infusion at later time points post-CLP (up to 6 h after CLP). Significant adjunctive effects on mouse survival were observed by i.p. or i.v. infusion of shCD6 in combination with i.p. I/C post-CLP. Similar results were obtained in mice expressing high sustained levels (5 to 10 μg/ml) of mouse sCD6 in serum by means of transduction with hepatotropic adeno-associated virus (AAV). Taken together, the data support the conserved antibacterial effects of human and mouse sCD6 and their use as adjunctive therapy in experimental models of complex and severe polymicrobial sepsis.
Crystallization Elution Fractionation and Thermal Gradient Interaction Chromatography. Techniques Comparison (2012)

Abstract Summary: The chemical composition distribution has been shown to be the most critical and discriminating parameter in understanding the performance of industrial polyolefins with non homogeneous comonomer incorporation. The chemical composition distribution is being analyzed by well known techniques such as temperature rising elution fractionation, TREF, crystallization analysis fractionation, CRYSTAF and crystallization elution fractionation, CEF. These techniques separate according to crystallizability and provide a powerful and predictable separation of components based on the presence of branches, irregularities or tacticity differences, independently of the molar mass. TREF, CRYSTAF and CEF can not be used, however, for the separation of more amorphous resins, and may not always provide the best solution for complex multi‐component resins due to the existence of some co‐crystallization. The application of high temperature interactive HPLC to polyolefins opened a new route to characterize these types of polymers. The use of solvent gradient HPLC for separation of polyethylene and polypropylene and the developments in HPLC on carbon based columns extended further the application of high temperature HPLC in polyolefins. A new approach has been developed recently using the carbon based column but replacing solvent gradient by a thermal gradient which facilitates the analysis of polyethylene copolymers and provides a powerful tool for the analysis of elastomers. Thermal gradient interaction chromatography (TGIC) is being compared with TREF and CEF with the analysis of model samples. The advantages/disadvantages of each technique are being investigated and discussed. The combination of TGIC and TREF/CEF provides an extended range of separation of polyolefins.
p53 suppresses the self-renewal of adult neural stem cells (2005)

There is increasing evidence that tumors are heterogeneous and that a subset of cells act as cancer stem cells. Several proto-oncogenes and tumor suppressors control key aspects of stem cell function, suggesting that similar mechanisms control normal and cancer stem cell properties. We show here that the prototypical tumor suppressor p53, which plays an important role in brain tumor initiation and growth, is expressed in the neural stem cell lineage in the adult brain. p53 negatively regulates proliferation and survival, and thereby self-renewal, of neural stem cells. Analysis of the neural stem cell transcriptome identified the dysregulation of several cell cycle regulators in the absence of p53, most notably a pronounced downregulation of p21 expression. These data implicate p53 as a suppressor of tissue and cancer stem cell self-renewal.
Topotecan inhibits VEGF‐ and bFGF‐induced vascular endothelial cell migration via downregulation of the PI3K‐Akt signaling pathway (2001)

Angiogenesis plays a crucial role in tumor growth and metastases. The extent of angiogenesis correlates with the increased invasion and metastasis in a variety of human neoplasms. Vascular endothelial cell proliferation and migration are critical steps in angiogenesis and are regulated by various growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). The topoisomerase I inhibitor topotecan (10-hydroxy-9-dimethylaminomethyl-(S)-camptothecin) is a water-soluble camptothecin analogue and possesses an indirect in vivo antitumor effect mediated through the inhibition of angiogenesis. We found that topotecan inhibited VEGF- and bFGF-induced migration of human umbilical vein endothelial cells (HUVECs) in vitro. The migration of HUVECs was also inhibited by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002. Thus, we investigated the possibility that topotecan's antiangiogenic property might be mediated by its inhibitory effect on VEGF- and bFGF-induced activation of the PI3K-Akt signaling pathway. We found that topotecan treatment decreased the amount of the phosphorylated (activated) form of Akt, but not the amount of Akt protein, in HUVECs. Moreover, transient transfection of constitutive active akt cDNA into HUVECs reversed the topotecan-mediated decrease in HUVEC migration. These results suggest that the antiangiogenic activity of topotecan is mediated in part by downregulating the PI3K-Akt signaling pathway.
The State‐Business Relations in the Era of Globalization: The Case of Russia* (2003)

This article examines the potential prospects of change in the state‐business relationship in Russia with an emphasis on the effects of globalization. The establishment of an efficient relationship between the state and private business has been one of the key challenges in post‐communist era development. Globalization compels the rapid adjustment in state‐business relations in new democracies in former communist countries. This paper analyzes the main features of Russia's “oligarchic capitalism” and plausible sources of change in its state‐business relationship. However, it concludes that in view of the current stage of development in both economic globalization and social activism, it will take time to see any profound changes in the state‐business relationship in Russia.
Metal gate work function tuning by Al incorporation in TiN (2014)

Titanium nitride (TiN) films have been used as gate electrode on metal-oxide-semiconductor (MOS) devices. TiN effective work function (EWF) values have been often reported as suitable for pMOS. For nMOS devices, a gate electrode with sufficient low EWF value with a similar robustness as TiN is a challenge. Thus, in this work, aluminum (Al) is incorporated into the TiN layer to reduce the EWF values, which allows the use of this electrode in nMOS devices. Titanium aluminum (TiAl), Al, and aluminum nitride (AlN) layers were introduced between the high-k (HfO2) dielectric and TiN electrode as Al diffusion sources. Pt/TiN (with Al diffusion) and Pt/TiN/TiAl/TiN structures were obtained and TiN EWF values were reduced of 0.37 eV and 1.09 eV, respectively. The study of TiN/AlN/HfO2/SiO2/Si/Al structures demonstrated that AlN layer can be used as an alternative film for TiN EWF tuning. A decrease of 0.26 eV and 0.45 eV on TiN EWF values were extracted from AlN/TiN stack and AlN/TiN laminate stack, respectively. AlN/TiN laminate structures have been shown to be more effective to reduce the TiN work function than just increasing the AlN thickness.
Biochemical Defects in 11-cis-Retinol Dehydrogenase Mutants Associated with Fundus Albipunctatus (2001)

Mutations in the gene encoding 11-cis-retinol dehydrogenase (RDH5; EC ) are associated with fundus albipunctatus, an autosomal recessive eye disease characterized by stationary night blindness and accumulation of white spots in the retina. In addition, some mutated alleles are associated with development of cone dystrophy, especially in elderly patients. The numbers of identified RDH5 mutations linked to fundus albipunctatus have increased considerably during recent years. In this work, we have characterized the biochemical and cell biological properties of 11 mutants of RDH5 to understand the molecular pathology of the disease. All RDH5 mutants showed decreased protein stability and subcellular mislocalization and, in most cases, loss of enzymatic activity in vitro and in vivo. Surprisingly, mutant A294P displays significant enzymatic activity. Cross-linking studies and molecular modeling showed that RDH5 is dimeric, and co-expression analyses of wild-type and mutated alleles showed that the mutated enzymes, in a trans-dominant-negative manner, influenced the in vivo enzymatic properties of functional variants of the enzyme, particularly the A294P mutant. Thus, under certain conditions, nonfunctional alleles act in a dominant-negative way on functional but relatively unstable mutated alleles. However, in heterozygous individuals carrying one wild-type allele, the disease is recessive, probably due to the stability of the wild-type enzyme.
Machine learning-based prefetch optimization for data center applications (2009)

Performance tuning for data centers is essential and complicated. It is important since a data center comprises thousands of machines and thus a single-digit performance improvement can significantly reduce cost and power consumption. Unfortunately, it is extremely difficult as data centers are dynamic environments where applications are frequently released and servers are continually upgraded.
The in Vitro and in Vivo Antitumor Activities of Tetracyclic Triterpenoids Compounds Actein and 26-Deoxyactein Isolated from Rhizome of Cimicifuga foetida L. (2016)

Both actein and 26-deoxyactein have low toxicities. Importantly, both these two tetracyclic triterpenoids compounds isolated from rhizome of Cimicifuga foetida L. have significant antitumor activities in vitro and in vivo, which is associated with cell cycle arrest and angiogenesis inhibition.
Intracerebroventricular Injection of Tumor Necrosis Factor-αInduces Thermal Hyperalgesia in Rats (1996)

To investigate the role of tumor necrosis factor-alpha (TNF-alpha) in the brain in nociception, we injected recombinant human TNF-alpha (rhTNF-alpha; 1 pg-10 ng/rat) into the lateral cerebroventricle (LVC) in rats and observed the changes in paw withdrawal latency to radiant heat by using the plantar test for 90 min after injection. LCV injections of TNF-alpha at doses of 10 pg, 100 pg and 1 ng reduced paw withdrawal latency, showing a maximal response at a dose of 10 pg which peaked 60 min after injection. TNF-alpha at doses of 1 pg and 10 ng had no effect on nociception during the test period. The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng). LCV injection of neither diclofenac (1 ng) nor IL-1 ra (10 ng) had any effect on nociception by itself. The results suggest that TNF-alpha in the brain induces thermal hyperalgesia and that the brain TNF-alpha-induced hyperalgesia is mediated by the central action of interleukin-1 and activation of the cyclooxygenase pathway of the arachidonate.
Peace Metaphor : A Rhetoric of Occupation in Postwar Okinawa (2005)

After reviewing the litertature on conceptual methaphors and presenting an analytical model of political discourse, this paper examines some U.S.-Okinawa postwar public discourese that centers on the notion of peace. If first identifies some dominant conceptual metaphors of peace(I.e.,PEACE IS JOURNEY; PEACE IS WAR) in American public discourse on postwar Okinawa. Then, along the dimensions of space, time, and modality, it deictically represents the ongnitive semantic sphere of conceptual metaphors. The analysis of metaphors reveals how peace justifies war, and how the JOURNEY-WAR metaphor is embodied in the everyday public activities of American political actors.
Dose titration of <scp>BAF</scp>312 attenuates the initial heart rate reducing effect in healthy subjects (2012)

Both titration regimens effectively attenuated the initial bradyarrhythmia observed on day 1 of treatment with BAF312 10 mg.
Characterization and evolution of a single-copy sequence from the human Y chromosome. (1985)

To study the evolution and organization of DNA from the human Y chromosome, we constructed a recombinant library of human Y DNA by using a somatic cell hybrid in which the only cytologically detectable human chromosome is the Y. One recombinant (4B2) contained a 3.3-kilobase EcoRI single-copy fragment which was localized to the proximal portion of the Y long arm. Sequences homologous to this human DNA are present in male gorilla, chimpanzee, and orangutan DNAs but not in female ape DNAs. Under stringent hybridization conditions, the homologous sequence is either a single-copy or a low-order repeat in humans and in the apes. With relaxed hybridization conditions, this human Y probe detected several homologous DNA fragments which are all derived from the Y in that they occur in male DNAs from humans and the apes but not in female DNAs. In contrast, this probe hybridized to highly repeated sequences in both male and female DNAs from old world monkeys. Thus, sequences homologous to this probe underwent a change in copy number and chromosomal distribution during primate evolution.
Oil Core and Silica Shell Nanocapsules:  Toward Controlling the Size and the Ability To Sequester Hydrophobic Compounds (2005)

Nanocapsules were synthesized using the droplets of an oil-in-water microemulsion as a template. Ethyl butyrate was solubilized in normal saline using Tween-80, lecithin, and n-octadecyltrimethoxysilane as surfactants. A polysiloxane/silicate shell was formed at the surface of the mixed surfactant layer by cross-linking n-octadecyltrimethoxysilane and tetramethoxysilane. The shell stabilized the oil droplets against coalescence as seen by transmission electron microscopy (TEM) of the samples immediately following the synthesis and months afterward. The diameter of nanocapsules can be controlled by using different component ratios, as measured by quasi-elastic light scattering (QELS) and TEM. The efficacy of nanocapsules to sequester hydrophobic compounds made by using different formulations was studied by UV−visible spectrometry. The results showed that nanocapsules with smaller diameters are generally more efficient in the uptake process than larger ones.
A review on lithium recovery using electrochemical capturing systems (2020)

Resource recovery from natural reserves is appealing and Li extraction from different brines is in the forefront. Li extraction by membranes is reviewed in the literature much more than electrochemical processes. However, a very recent review thoroughly discussed Li recovery by electrochemically switchable ion exchange (ESIX). This paper reviews Li recovery by both charge transfer processes, namely electrodialysis (ED), and electro-sorption processes, namely capacitive deionization (CDI). It also reviews ESIX with a focus on performance matrices and includes comments on the technology readiness of each separation technique. These processes exhibit promising perspectives on the separation and recovery of Li both selectively and non-selectively from simulated brine solutions and Li salt solutions. Readers are provided with guidelines to choose between the processes, depending on the applied voltage, current density, specific energy consumption and purity of recovered Li. Most electrochemical lithium capturing systems (ELiCSs) have been tested at the lab scale. Therefore, future research should be directed toward pilot-scale development and parameter optimization. Furthermore, we urge the ELiCSs research community to report information in a standard form that allows meaningful comparisons and insights into the systems.
Production and Performance of Hybrid Soybeans<sup>1</sup> (1984)

The quest for hybrid cultivars in self‐pollinated crops has been encouraged by the great success achieved in hybrid corn ( Zea mays L.). However, because past research has relied on hand pollinations to produce hybrid seeds in soybeans [ Glycine max (L.) Merr.] very little is known about the performance of hybrid soybeans. The objectives of this study were to look for heterosis in seed yield of soybean hybrids and to compare other characteristics in the hybrids with those of the parents. All hybrid seeds in this study were produced using genetic male sterility and insect pollination. The experiments were grown at Urbana, III. in a Flanagan silt loam (Aquicarguidoll) and Belleville, 111. in an Ebert silt loam (Argiaquicargialdoll), in 1977 and 1978. Agronomic data were collected from 27 hybrid combinations grown in replicated, bordered plots. Five hybrids yielded significantly more (13 to 19%) than their better parent in at least one season. Only one hybrid exceeded the yield of the best pure‐line cultivar in the test. The yield performance of the hybrids could not be predicted from their pedigrees. Several hybrids significantly exceeded the height of the taller parent, but, with few exceptions, no high‐parent heterosis was observed for maturity date, lodging score, harvest index, seed quality, seed weight, oil percentage, or protein percentage. Significant heterosis was observed even though relatively few hybrids were tested and the parents were unselected for combining ability. The inability to produce large quantities of hybrid seeds economically is the major barrier to the use of commercial hybrid soybean cultivars.
Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity (2011)

One-third of all splenic marginal zone lymphomas (SMZL) use the IgH VH1-02 gene. These cases are usually not associated with hepatitis C virus infection. Of interest, the rearranged VH1-02 genes display similar complementarity determining regions 3, a finding confirmed by our study. The latter suggests that these SMZL may produce antibodies with similar reactivity. We produced recombinant antibodies from 5 SMZL cases with VH1-02 gene rearrangement to study the binding reactivity of these antibodies. Surprisingly, the recombinant antibodies demonstrated poly- and self-reactivity as demonstrated by their reactivity with nuclear, cytoplasmic, as well as membranous antigens expressed by human cells and by reactivity with human serum. This polyreactivity was specific as demonstrated by ELISA. The antibodies did not react with proteins on the cell surface that are induced by apoptosis as shown for antibodies produced by chronic lymphatic leukemia with VH1-02 gene rearrangement. The results indicate that a common subset of SMZL arises from polyreactive B cells, a subset of marginal zone B cells that are important in the immunologic defense against infection.
Twenty‐six years of meniscal allograft transplantation: is it still experimental? A meta‐analysis of 44 trials (2010)

IV.
Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules (2013)

Effective drug discovery and optimization can be accelerated by techniques capable of deconvoluting the complexities often present in targeted biological systems. We report a single-molecule approach to study the binding of an alternative splicing regulator, muscleblind-like 1 protein (MBNL1), to (CUG)n = 4,6 and the effect of small molecules on this interaction. Expanded CUG repeats (CUG(exp)) are the causative agent of myotonic dystrophy type 1 by sequestering MBNL1. MBNL1 is able to bind to the (CUG)n-inhibitor complex, indicating that the inhibition is not a straightforward competitive process. A simple ligand, highly selective for CUG(exp), was used to design a new dimeric ligand that binds to (CUG)n almost 50-fold more tightly and is more effective in destabilizing MBNL1-(CUG)4. The single-molecule method and the analysis framework might be extended to the study of other biomolecular interactions.
A comparison of robust methods and detection of outliers techniques when estimating a location parameter (1984)

Although the poor performance of the mean as a location estimate when outliers are present in the data is well-known, there has b.een no clear consensus as to whether robust estimation or outlier detection Is the appropriate corrective procedure. In this paper, the estimation accuracy of the sample mean and 27 robust estimation and outlier detection techniques are compared by computer simulation. Both symmetric and asymmetric contamination are considered, It Is shown that the proper class of estimates depends on the degree of contaminations whether the contamination is symmetric or asymmetric, and the sample size. Several data sets considered previously by Rocke et.al. (1982) are also examined.
Biological modification of oil composition (1985)

Abstract Prospects for modification of palm oil composition through oil palm breeding, tissue culture and enzyme‐catalyzed transesterification are reviewed. Present emphasis in oil modification is toward greater unsaturation. The greatest prospect for this area lies in the interspecific hybridization of E. oleifera and E. guineensis . The target recommended is for a hybrid oil of iodine value above 72 having a palmitic acid content below 25% and an oleic acid content above 60%. It is noted that the variability of linoleic acid in the oil palm is limited regardless of species. The greatest contribution towards unsaturation, therefore, lies mainly in oleic acid. Tissue culture is seen as a potential propagating tool for selecting progenies of important crosses from the hybridization of E. oleifera and E. guineensis , while enzyme‐catalyzed transesterification using a 1,3 specific lipase offers the possibility of enhancing the level of linoleic acid in palm oil. Besides breeding for unsaturation, production of palms giving oils of specific fatty acid or triglyceride types also may be possible ultimately.