gebhart/patrepeval huggingface dataset:
Propagation of SIV Vectors by Genetic Complementation with a Heterologous <i>env</i> Gene (1992)

In order to study SIV replication over a single round of replication virus particles were generated that contain a replication-defective vector containing a selectable marker. Genetic complementation between an env-deficient SIV variant and plasmid that expresses the env gene of an amphotropic murine retrovirus resulted in infectious SIV particles containing the vector. These pseudotyped particles exhibited an expanded host range through the use of an alternative receptor. This system should be useful in the genetic analysis of SIV nucleic acid replication. To determine whether the terminal cis acting components of the SIV genome might be sufficient for viral nucleic acid propagation a vector was generated which lack the internally located rev-responsive element. Propagation of this vector was reduced by at least 100-fold.
Iron release and uptake by plant ferritin: effects of pH, reduction and chelation (1993)

Ferritins are iron-storage proteins that accumulate in plastids during seed formation, and also in leaves during senescence or iron overload. Iron release from ferritins occurs during growth of seedlings and greening of plastids. Depending on the concentration of the reducing agent ascorbate, either an overall iron release or uptake by ferritins from iron(III) citrate may occur. We have designed methods to measure these simultaneous and independent uptake and release fluxes. Each individual step of the exchange was studied using different iron chelates and an excess of ligand. It is shown that: (i) the chelated form of iron, and not ionic Fe3+, is the substrate for iron reduction, which controls the subsequent uptake by ferritin; (ii) iron uptake by ferritins is faster at pH 8.4 than at pH 7 or 6 and is inhibited by an excess of strongly binding free ligands; and (iii) strongly binding free ligands are inhibitory during iron release by ascorbate. When reactions are allowed to proceed simultaneously, the iron chelating power is shown to be a key factor in the overall exchange. The interactions of iron chelating power, reducing capacity and pH are discussed with regard to their influence on the biochemical mobilization of iron.
Anti-inflammatory effects of intramammary infusions of glycyrrhizin in lactating cows with mastitis caused by coagulase-negative staphylococci (2003)

Infusion of GL may regulate intramammary inflammation through modulation of inflammatory mediators such as histamine.
Sertindole, a New Atypical Antipsychotic for the Treatment of Schizophrenia (1998)

The introduction of antipsychotics for the management of schizophrenia greatly improved the quality of life of many patients suffering from this debilitating disease. Although typical antipsychotic drugs represent a significant advancement in psychopharmacology, they carry a heavy side effect burden, have little efficacy in the management of negative symptoms, and are ineffective in about one-third of patients with schizophrenia. Atypical antipsychotic agents characterized the next major advancement in pharmacotherapy. They differ from typical antipsychotics in their mechanism of action, side effect profiles, and clinical efficacy. Sertindole is a new atypical antipsychotic.
Large longitudinal electric fields (E_z) in silicon nanowire waveguides (2009)

We demonstrate the presence of strong longitudinal electric fields (E(z)) in silicon nanowire waveguides through numerical computation. These waveguide fields can be engineered through choice of waveguide geometry to exhibit amplitudes as high as 97% that of the dominant transverse field component. We show even larger longitudinal fields created in free space by a terminated waveguide can become the dominant electric field component, and demonstrate E(z) has a large effect on waveguide nonlinearity. We discuss the possibility of controlling the strength and symmetry of E(z) using a dual waveguide design, and show that the resulting longitudinal field is sharply peaked beyond the diffraction limit.
Enhanced CellClassifier: a multi-class classification tool for microscopy images (2010)

Here we describe Enhanced CellClassifier which allows multiple class classification, elucidating complex phenotypes. Our tool is designed for the biologist who wants both, simple and flexible analysis of images without requiring programming skills. This should facilitate the implementation of automated high-content screening.
Effects of water immersion on sympathoadrenal and dopa-dopamine systems in humans (1992)

Water immersion to the neck increases central blood volume and evokes a marked diuresis and natriuresis. The present study examined simultaneously effects of water immersion on activities of three endogenous systems thought to participate in sodium homeostasis: the sympathetic nervous system, the atrial natriuretic peptide system, and the renal dopa-dopamine system. Hourly urine collections and antecubital venous blood samples were obtained from 10 normal subjects before, during, and after sitting in a water-immersion tank for 3 h; four control subjects were studied while seated without immersion. Urine volume was increased by more than threefold after 1 h of immersion (from 1.2 +/- 0.2 ml/min at baseline to 5.9 +/- 0.7 ml/min, P less than 0.001) and peaked during the second hour. Urinary sodium excretion increased by more than twofold (from 103 +/- 17 mu eq/min at baseline to 196 +/- 36 mu eq/min at 1 h, P less than 0.001) and peaked during the third hour. Plasma levels and urinary excretion of norepinephrine (NE) and epinephrine were suppressed consistently during immersion (P less than 0.05). There was a marked, prompt, and sustained increase in plasma levels of immunoreactive atrial natriuretic factor (irANF) from 6.9 +/- 1.9 pg/ml baseline to 17.3 +/- 4.3 pg/ml at 1 h (P less than 0.001). Urinary excretion of dopa, dopamine, and 3,4-dihydroxyphenylglycol, a neuronal metabolite of NE, changed in a triphasic pattern, with decreased excretion during the first hour of immersion (P less than 0.01), small but consistent increases during the next 2 h, and decreased excretion, to below baseline, during recovery (P less than 0.01 for dopa and dopamine).(ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of Synthetic Crossbands for Wood Panels. (1976)

The performance of a five-ply panel is related to the thickness, tensile strength, modulus of elasticity, and dimensional movement with changes in moisture content of the crossband. Knowing these properties of the crossband, core, face, and back, it is possible to predict the dimensional movement of the panels with changes in moisture. Synthetic crossbands have dimensional properties; for optimum performance they, like veneer crossbands, should be placed with the strongest and most stable direction restraining the core, face and back. the gluing process may markedly alter the properties of the synthetic crossband. Consequently, the crossband should be evaluated as a three-ply parallel laminate as well as a single ply. (Author)
Optimal spectral reshaping for resolution improvement in optical coherence tomography (2006)

We analyze the resolution limit that can be achieved by means of spectral reshaping in optical coherence tomography images and demonstrate that the resolution can be improved by means of modelessly reshaping the source spectrum in postprocessing. We show that the optimal spectrum has a priori surprising "crater-like" shape, providing 0.74 micron axial resolution in free space. This represents ~50% improvement compared to resolution using the original spectrum of a white light lamp.
Characterization of laser-SOI double Si active layers by fabricating elementary device structures (1982)

Various active regions in a silicon-on-insulator (SOI) structure, prepared by seeded lateral-epitaxy using a scanned cw-Ar laser, are characterized by fabricating MOSFETs and diodes. The MOSFETs on both sides of the SOI layer exhibit a channel mobility of higher than 600cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /V.s. The p-n diodes in the seeding area show a forward current with an ideality factor of 1.2-1.4 and a reverse current level of 6x 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at 0.1V. A novel device structure is also presented where the diode forward current is controlled by a MOS gate.
Réforme du droit international privé du divorce et de la prévoyance professionnelle (2012)

Loi applicable au divorce d'abord.Pour mesurer la relle nouveaut que propose l'avant-projet de 2009 (qui est le dernier document officiel produit par l'administration fdrale), rappelons l'tat du droit actuel.C'est vers l'art.61 LDIP qu'il faut se tourner.Lequel prsente une structure sinueuse, alambique ont dit certains (dont moi-mme).L'alina 1 pose le principe de la soumission au droit suisse d'une demande en divorce dont a t rgulirement saisi un juge suisse.La saisine du juge suisse est rgulire, sur le plan de la comptence internationale : -ou bien lorsque le domicile de l'poux dfendeur se trouve en Suisse ou bien lorsque le domicile du demandeur se trouve en Suisse et que celui-ci rside en Suisse depuis une anne au moins ou est suisse.Le principe lex fori in foro proprio souffre toutefois d'une exception (formule l'alina 2).Il s'agit du cas des poux qui entretiennent une nationalit trangre commune et dont un seul est domicili en Suisse.C'est alors le droit tranger qui est aujourd'hui dsign.Donnons un exemple, sorti des archives de l'ISDC.Deux poux vnzueliens ont vcu en Suisse pendant un certain nombre d'annes.Monsieur a depuis plusieurs mois abandonn le domicile conjugal.On n'est pas exactement renseign sur son tablissement actuel (il est, comme on dit par un acronyme, PDV : perdu de vue ), mais il semble certain qu'il a quitt la Suisse.Eh bien, le droit vnzulien de la nationalit commune est en principe applicable la demande en divorce.Je dis bien en principe .Notons en effet, d'abord, que le renvoi au premier degr est admis.Et il jouait en effet bel et bien dans l'affaire voque.Car la loi vnzuelienne de 1999 soumet de son ct le divorce au droit de la rsidence du demandeur, en l'espce la Suisse.Autre assouplissement : la clause d'exception de l'art.15, laquelle habilite le juge, encore qu' des conditions restrictivement formulesje vais y revenir -, se replier sur un autre droit, notamment le sien.*** L'art.61 al. 2 ne fait pas de distinction selon que les poux sont d'accord ou non se soumettre au droit suisse.Puisons encore dans les archives de l'ISDC.Deux poux pruviens n'ont vcu ensemble qu'au Prou.Ils ont eu deux enfants.Aprs leur sparation, Monsieur s'est install en Suisse.Le droit pruvien soumet le divorce d'un couple avec enfants une sparation pralable de quatre ans.Monsieur et Madame souhaitent cette fois-ci de commun accord profiter du droit suisse du divorce.L'accs au droit suisse leur semble ferm.
Useful Immunohistochemical Markers of Tumor Differentiation (2009)

Immunohistochemistry (IHC) has been somewhat underutilized in the practice of toxicological pathology but can be a valuable tool for the evaluation of rodent neoplasms, both in a diagnostic and an investigational role. Determining an exact tumor type using standard hematoxylin and eosin (H&E) staining of formalin-fixed tissues can be challenging, especially with metastatic and/or poorly differentiated tumors. Successful IHC is dependent on many factors, including species and tissue type, type and duration of fixation, quality fresh or frozen sectioning, and antibody specificity. The initial approach of most tumor diagnosis IHC applications is distinguishing epithelial from mesenchymal differentiation using vimentin and cytokeratin markers, although false-negative and/or false-positive results may occur. Experimentally, IHC can be employed to investigate the earliest changes in transformed tissues, identifying cellular changes not normally visible with H&E. Individual markers for proliferation, apoptosis, and specific tumor proteins can be used to help distinguish hyperplasia from neoplasia and determine specific tumor origin/type. IHC provides a relatively rapid and simple method to better determine the origin of neoplastic tissue or investigate the behavior or progression of a given neoplasm. Several experimental and diagnostic examples will be presented to illustrate the utility of IHC as a supplement to standard staining techniques.
A Target of Phosphatidylinositol 3,4,5‐Trisphosphate with a Zinc Finger Motif Similar to that of the ADP‐Ribosylation‐Factor GTPase‐Activating Protein and Two Pleckstrin Homology Domains (1997)

We have purified a protein that binds phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] using beads bearing a PtdIns(3,4,5)P3 analogue. This protein, with a molecular mass of 43 kDa, was termed PtdIns(3,4,5)P3-binding protein. The partial amino acid sequences were determined and a full-length cDNA encoding the protein was isolated from bovine brain cDNA library. The clone harbored an open reading frame of 373 amino acids which contained one zinc finger motif similar to that of ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains. The entire sequence was 83% similar to centaurin alpha, another PtdIns(3,4,5)P3-binding protein. The protein bound PtdIns(3,4,5)P3 with a higher affinity than it did inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4-bisphosphate, and phosphatidylinositol 3-phosphate suggesting that the binding to PtdIns(3,4,5)P3 was specific. The binding activity was weaker in the mutants with a point mutation in the conserved sequences in each pleckstrin homology domain. Introduction of both mutations abolished the activity. These results suggest that this new binding protein binds PtdIns(3,4,5)P3 through two pleckstrin domains present in the molecule.
Molecular, cellular, and tissue responses following photodynamic therapy (1988)

Photodynamic therapy (PDT) is being utilized in the treatment of a wide variety of malignant tumors. Results using PDT have been encouraging, and controlled clinical trials are currently being performed. The procedure exploits both the tumor-localizing and -photosensitizing properties of hematoporphyrin derivative or its purified component, Photofrin II. When this porphyrin mixture is administered systemically, it is retained preferentially in tumor tissue as compared to surrounding normal tissue. Localized tumor destruction induced by PDT results from the photochemical generation of cytotoxic oxygen species within the tumor. This review will provide a summary of historical and current research pertaining to molecular, cellular, and tissue responses induced by PDT. Emphasis is placed on information related to the chemistry of current photosensitizers, subcellular targets, preclinical treatment parameters, and clinical responses following PDT.
The smoothed coherence transform (1973)

The smoothed coherence transform (SCOT) is defined and examples of its uses and shortcomings are given. Computation of this function shows promise for measuring time delays between weak broad-band correlated noises received at two sensors.
Implementation and application of first-in first-out buffers (2003)

First-in, first-out (FIFO) buffers load and unload data using separate clocks that may be incoherent. We explore the application of FIFOs to circular shift registers, serial memory, and data re-clocking. We describe two different FIFO implementations in RSFQ. One employs classic handshaking using the Muller C-element. The other employs physical back-pressure based on repulsion of stored single flux quanta in a JTL. Both implementations use seven Josephson junctions, and a single bias resistor, per cell. The bias resistor can be reduced to an arbitrarily low value, thereby eliminating static power dissipation.
Study of Convolvulus pluricaulis for Antioxidant and Anticonvulsant Activity (2012)

Convolvulus pluricaulis Choisy is a perennial wild herb commonly found on sandy & rocky areas under xerophytic conditions in northern India. It is a reputed drug of ayurveda and reported to posses antioxidant, brain tonic, nervine tonic, laxative and has been used in anxiety, neurosis, epilepsy, insomnia, burning sensation, oedema and urinary disorders. In the present study, methanolic extract of whole plant of Convolvulus pluricaulis Choisy was evaluated for antioxidant activity by using 1, 1-diphenyl-2-picryl- hydrazyl (DPPH) free radical scavenging model and anticonvulsant activity by using maximal electroshock seizure model. In antioxidant activity, ascorbic acid was used as standard agent while results of anticonvulsant studies were compared with phenytoin. Results of antioxidant activity have demonstrated significant free radical scavenging effect for methanolic extract of Convolvulus pluricaulis Choisy. IC50 value of methanolic extract was observed as 41.00μg/ml as compared to 2.03μg/ml of ascorbic acid. Methanolic extract of C. pluricaulis was evaluated for anticonvulsant activity at 250, 500 and 1000mg/kg. Experimental results have shown that at the dose of 500 and 1000mg/kg, C. pluricaulis didn't abolish the hind limb extension, but reduced the mean recovery time from convulsion.
INFLUENCE OF ULTRAVIOLET IRRADIATION UPON EXCRETION OF SEX HORMONES IN THE MALE1<sup>1</sup> (1939)

Journal Article INFLUENCE OF ULTRAVIOLET IRRADIATION UPON EXCRETION OF SEX HORMONES IN THE MALE1 Get access ABRAHAM MYERSON, ABRAHAM MYERSON 1From the Division of Psychiatric Research, Boston State Hospital BOSTON, MASSACHUSETTS Search for other works by this author on: Oxford Academic Google Scholar RUDOLPH NEUSTADT RUDOLPH NEUSTADT 1From the Division of Psychiatric Research, Boston State Hospital BOSTON, MASSACHUSETTS Search for other works by this author on: Oxford Academic Google Scholar Endocrinology, Volume 25, Issue 1, 1 July 1939, Pages 7–12, https://doi.org/10.1210/endo-25-1-7 Published: 01 July 1939
Production of Aujeszky vaccine by the microcarrier technology "from the ampoule to the 500 litre fermentor". (1987)

A process for the production of Aujeszky vaccine on microcarrier cultures in large fermentors is described. The NLST cells are routinely produced in fermentors of 150 litres; cell density reaches 0.7-0.8 10(6)/ml. The authors describe the method used to obtain those results. The different parameters used in fermentors are discussed and especially pO2 regulation. A study of subculturing method is being carried out to reach a volume of 500 litres. The comparison between stationary culture and microcarrier cultures shows the advantages of such a technique for the viral antigen produced versus infective and the increase of the bulk capacity. This experience also shows that specific development is required for each cell line.
Lipids of <i>Debaryomyces hansenii</i> (1965)

Merdinger, Emanuel (Roosevelt University, Chicago, Ill.), and Edward M. Devine, Jr. Lipids of Debaryomyces hansenii. J. Bacteriol. 89:1488-1493. 1965.-The separation of neutral lipids and phospholipids from the lipid extract of Debaryomyces hansenii NRRL Y-1448 was accomplished by using a single column packed with silicic acid. The neutral lipids comprised 67%, and the phospholipids 33%, of the total lipid extract. Qualitative and quantitative characterization of the lipids was effected by various analytical procedures. Gas chromatography of the fatty acid methyl esters showed 11 acids, of which 59.7% were unsaturated. The most abundant among the unsaturated acids was the monounsaturated C18 acid (50.1%). Among the saturated acids, palmitic acid (23.5%) prevailed. Ratios of fatty acid to glycerol, phosphorus to glycerol, and phosphorus to fatty acid were ascertained for combined cuts from the neutral lipids and the phospholipids. The presence of ergosterol, stigmasterol, and an unidentified sterol was established by gas chromatography. Also present were saturated hydrocarbons containing 16 to 39 carbon atoms, C22 being the most prevalent.
Test-retest reliability and minimal detectable change of two simplified 3-point balance measures in patients with stroke (2017)

Our findings support the repeated administration of the BBS-3P and PASS-3P to monitor the balance of patients with stroke. The MDC values can help clinicians and researchers interpret the change scores more precisely.
Azoles for allergic bronchopulmonary aspergillosis associated with asthma (2004)

Itraconazole modifies the immunologic activation associated with allergic bronchopulmonary aspergillosis and improves clinical outcome, at least over the period of 16 weeks. Adrenal suppression with inhaled corticosteroids and itraconazole is a potential concern.
SOCS Proteins in Macrophage Polarization and Function (2014)

OPINION article Front. Immunol., 28 July 2014Sec. Molecular Innate Immunity Volume 5 - 2014 | https://doi.org/10.3389/fimmu.2014.00357
CERAMIC GAS- TURBINE ENGINE DEVELOPMENT, (1977)

Justification for the allocation of major resources to develop the ceramic gas turbine engine requires a reasonable prospect of obtaining significant improvements in engine performance, durability, reduction in critical materials use, and cost savings on a comparative basis to current-art metal gas turbine engines. Improved engine durability at existing operating conditions is the Navy's top priority for materials development. Ceramics have much greater resistance to hot-corrosion than metal alloys. Hot-corrosion of hot-section components is life-limiting engines. Ceramic hot-section components would be much more able to withstand hot-streaking, i.e., carbon burning on the vane air foil surface. These corrosion and thermal properties of ceramics would provide a much expanded tolerance for fuel impurities or with the synthetic fuels anticipated in the 1980's.
Peptide functionalized superparamagnetic iron oxide nanoparticles as MRI contrast agents (2011)

Magnetic resonance imaging (MRI) attracts great attention in cellular and molecular imaging due to its non-invasive and multidimensional tomographic capabilities. Development of new contrast agents is necessary to enhance the MRI signal in tissues of interest. Superparamagnetic iron oxide nanoparticles (SPIONs) are used as contrast agents for signal enhancement as they have revealed extraordinary magnetic properties at the nanometre size and their toxicity level is very low compared to other commercial contrast agents. In this study, we developed a new method to functionalize the surface of SPIONs. Peptide amphiphile molecules are used to coat SPIONs non-covalently to provide water solubility and to enhance biocompatibility. Superparamagnetic properties of the peptide–SPION complexes and their ability as contrast agents are demonstrated. In vitrocell culture experiments reveal that the peptide–SPION complexes are biocompatible and are localized around the cells due to their peptide coating.
Electrical properties of inorganic nanowire–polymer composites (2005)

Composites of nanowires of ZnO, RuO2 and Ag with polyaniline (PANI) as well as polypyrrole (PPy) have been prepared, for the first time, by an in-situ process, in order to investigate their electrical properties. Characterization by electron microscopy and IR spectroscopy indicates that there is considerable interaction between the oxide nanowires and the polymer. The room-temperature resistivity of the composites prepared in-situ varies in the 0.01–400 Ω cm range depending on the composition. While the resistivities of the PANI–ZnONW and PPy–ZnONW composites prepared by the in-situ process are generally higher than that of PANI/PPy, those of PANI–RuO2NW and PANI–AgNW are lower. Composites of ZnONW with polyaniline prepared by an ex-situ process exhibit a resistivity close to that of polyaniline.