gebhart/patrepeval huggingface dataset:
Synthesis and Structural Characterization of Silk-Like Materials Incorporated with an Elastic Motif (2003)

Genetic engineering strategies were applied to synthesize silk-like materials, [(GVPGV)(2)GG(GAGAGS)(3)AS](n). The primary structure of these materials represents the repetitive crystalline region of Bombyx mori silk fibroins incorporated with an elastic motif selected from animal elastin. The oligonucleotides were designed to encode the desired recombinant proteins and then expressed in the Escherichi coli system. The expression and purification conditions for the production of the recombinant proteins were optimized. (13)C CP/MAS NMR was used for structural characterization in the solid state, where the isotope labeling was performed using a modified M9 medium. The secondary structures of these materials are primarily governed by the designated amino acid sequence, where the B. mori silk fibroin block, (GAGAGS)(3), tends to form the crystalline region, which is interrupted by the flexible (GVPGV)(2) block. The CD data suggested that the structure of these materials was length-dependent in the solution state, i.e., a higher molecule weight leads to a higher ordered structure.
Estimating Security Price Derivatives Using Simulation (1996)

Simulation has proved to be a valuable tool for estimating security prices for which simple closed form solutions do not exist. In this paper we present two direct methods, a pathwise method and a likelihood ratio method, for estimating derivatives of security prices using simulation. With the direct methods, the information from a single simulation can be used to estimate multiple derivatives along with a security's price. The main advantage of the direct methods over resimulation is increased computational speed. Another advantage is that the direct methods give unbiased estimates of derivatives, whereas the estimates obtained by resimulation are biased. Computational results are given for both direct methods, and comparisons are made to the standard method of resimulation to estimate derivatives. The methods are illustrated for a path independent model (European options), a path dependent model (Asian options), and a model with multiple state variables (options with stochastic volatility).
A tank fish recognition and tracking system using computer vision techniques (2010)

Aquarium usually provides the visitors with pictures and some description of the fishes in the exhibition tank. In this paper, an intelligent fish recognition system using computer vision is proposed to help aquarium to educate people about the fishes in the tank. The designed system provides a convenient and friendly interface to help the users to retrieve the related fish information they are interested. The system includes three sub-systems: (1) fish object detection system (2) fish object tracking system (3) fish object recognition system. Two types of fish indexing system (offline and real time) have been designed and implemented.
Artefactos paleolíticos de una tumba en Garzón, Huila (1957)

En una tumba del Municipio de Garzón, Departamento del Huila, se hallaron restos de Megaterio y Mastodonte junto con instrumentos de piedra (xilópalo) tallada. Una comisión del Instituto Geológico Nacional completó la excavación de la tumba y constató que estaba llena de una mezcla de arcilla, tierra y piedras, en la cual estaban distribuídos los huesos fósiles y los artefactos. Aparentemente la tumba fue varias veces excavada y rellenada, quitándole, de tal manera, casi todo su valor científico. Sin embargo, a una distancia de ½ - 1 m. de la tumba, las capas están intactas y muestran su posición original. El infrayacente consta de arenisca y greda de la formación Honda (Mioceno). Sobre estos sedimentos reposan depósitos de 1 m. de espesor aproximadamente, pertenecientes a una terraza pleistocena que está colocada a 145 m. sobre el nivel actual del río Magdalena. La base de esta terraza representa una capa cultural, en la cual encontramos in situ otros huesos fósiles y artefactos del mismo tipo de los que se hallaron distribuídos en la tumba. La edad precisa de la terraza y de los vertebrados fósiles se desconoce, pero es probable que pertenezca al Pleistoceno Medio o acaso al Inferior. Por lo tanto no se puede descartar una edad igual para los artefactos de la capa cultural.
Bioceramic Implants in Surgically Produced Infrabony Defects (1975)

Tricalcium phosphate ceramic of hydroxyapatite structure with 50% porosity and 800- to 1000-mum pore diameter was implanted in surgically produced infrabony defects in dogs. The defects were evaluated histologically at different time intervals, 1, 2, 4, 8, 16, and 24 weeks. The results show that the ceramic is well tolerated by the tissue and yields no toxic reactions. Bone ingrowth into the pores and repair of the periodontium are clearly demonstrated. No significant hematological changes were observed.
<title>MSM-photodetectors with corrugated metal-semiconductor-interface based on III-V semiconductors</title> (1997)

The results of investigation for two types of GaAs(InP) based MSM photodetectors are described: 1) on quasiperiodical surfaces as light radiation detectors with enhanced photosensitivity throughout the spectral sensitivity range of device; 2) on holographic gratings as detectors having selective sensitivity respect to wavelength, polarization and incidence angle of light. The electrophysical parameters of Au(Ag)-GaAs(InP) MSM- photodetectors - current transport mechanism, interface recombination velocity, minority carrier diffusion length etc. - the spectral, angular, and polarization characteristics of their photosensitivity have been determined. Surface plasmon polariton excitation is shown to be an additional mechanism of photosensitivity enhancement for MSM photodetectors with corrugated surface. The passivation of corrugated surfaces in aqueous solution of sulfides was used for further improvement of photodetector sensitivity. The optimum regimes of chemical processing of texturation and passivation have been determined.
Improved methods for language model based question classification (2007)

In this paper, we propose a language model based approach to classify user questions in the context of question answering systems. As categorization paradigm, a Bayes classifier is used to determine a corresponding semantic class. We present experiments with state-of-the-art smoothing methods as well as with some improved language models. Our results indicate that the techniques proposed here provide performance superior to the standard methods, including support vector machines.
Modulation of type M <sub>2</sub> pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein (1999)

We report here that the E7 oncoprotein encoded by the oncogenic human papillomavirus (HPV) type 16 binds to the glycolytic enzyme type M2 pyruvate kinase (M2-PK). M2-PK occurs in a tetrameric form with a high affinity to its substrate phosphoenolpyruvate and a dimeric form with a low affinity to phosphoenolpyruvate, and the transition between both conformations regulates the glycolytic flux in tumor cells. The glycolytic intermediate fructose 1, 6-bisphosphate induces the reassociation of the dimeric to the tetrameric form of M2-PK. The expression of E7 in an experimental cell line shifts the equilibrium to the dimeric state despite a significant increase in the fructose 1,6-bisphosphate levels. Investigations of HPV-16 E7 mutants and the nononcogenic HPV-11 subtype suggest that the interaction of HPV-16 E7 with M2-PK may be linked to the transforming potential of the viral oncoprotein.
Effect of substituents on the melting points and spectroscopic characteristics of some popular scintillators (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of substituents on the melting points and spectroscopic characteristics of some popular scintillatorsS. Gershuni, M. Rabinovitz, I. Agranat, and I. B. BerlmanCite this: J. Phys. Chem. 1980, 84, 5, 517–520Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://doi.org/10.1021/j100442a013RIGHTS & PERMISSIONSArticle Views144Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (538 KB) Get e-Alerts
Uprating of a single inline memory module (2002)

Uprating is the process of assessing the ability of a part to meet the functionality and performance requirements for the application in which the part is used outside the manufacturer-specified temperature range. Uprating is considered when there are no electronic parts rated to operate at the required application temperature and other alternatives are found to be technically incompatible or inadequate. This paper presents a case study of an uprating assessment of single inline memory modules. The focus of the study was to determine if the modules could operate at extended temperatures for extended periods of time. The results established the ability of the parts to function at high temperature for extended periods.
Impact of qEEG-Guided Coherence Training for Patients with a Mild Closed Head Injury (2002)

Background. Mild closed head injury (MHI) is a major problem in our society. Traditional methods of treatment such as cognitive rehabilitation or behavioral training are time consuming, expensive, and of questionable effectiveness. Anecdotal reports indicate that neurofeedback can remediate the symptoms of MHI in a rapid and cost effective way. The purpose of this study is to evaluate whether quantitative electroencephalography (qEEG) guided coherence training is effective in remediating residual symptoms of MHI.
Suramin treatment suppresses induction of experimental autoimmune uveoretinitis (EAU) in rodents (1995)

The experimental drug suramin has been shown to possess several immunosuppressive properties. In this study we investigated the effect of suramin on the development of experimental autoimmune uveoretinitis (EAU) in mice and in rats. EAU was induced either by active immunization with a uveitogenic protein or peptide, or by the adoptive transfer of a uveitogenic T cell line. The development of EAU was assessed by clinical evaluation as well as by histopathology. Immunological responses were measured by delayed type hypersensitivity (DTH), lymphocyte proliferation, and serum antibody levels to the immunizing antigen. Suramin treatment was most effective in suppressing EAU when started concurrently with immunization (afferent). Treatment was less effective in suppressing disease when first administered 7 days after immunization or when given to animals that received an adoptive transfer of uveitogenic T cells (efferent). The effect of suramin on DTH and lymphocyte proliferation roughly paralleled its effect on EAU. Aferent treatment of mice with suramin completely suppressed anti-IRBP antibody titers. Interestingly, animals receiving efferent treatment had unreduced IgM levels but little or no IgG, suggesting prevention of the IgM-to-IgG switch. Depressed in vitro lymphocyte proliferative responses in animals treated with suramin during the afferent stage suggested that the suppressive effect on disease was due at least in part to an inhibition of antigen priming. Our results suggest that suramin merits further investigation as a potential treatment for some types of uveitis.
Evidence for Combinatorial Variability of Tenascin-C Isoforms and Developmental Regulation in the Mouse Central Nervous System (1999)

The extracellular matrix glycoprotein tenascin-C (TN-C) displays a restricted and developmentally regulated distribution in the mouse central nervous system. Defined modules of the molecule have been shown to mediate specific functions, such as neuron migration, neurite outgrowth, cell adhesion, and cell proliferation. The smallest TN-C form contains a stretch of eight fibronectin type III (FNIII) domains, which are common to all TN-C isoforms. Unrestricted and independent alternative splicing of six consecutive FNIII cassettes between the fifth and sixth constitutive FNIII domain bears the potential to generate 64 different combinations that might code for TN-C proteins with subtly different functions. To explore TN-C isoform variability in mouse brain, the alternatively spliced region of TN-C mRNAs was examined by the reverse transcription-polymerase chain reaction technique. Polymerase chain reaction products of uniform size were subcloned and analyzed using domain-specific probes to reveal the expression of particular combinations of alternatively spliced FNIII domains. 27 TN-C isoforms were identified to be expressed in mouse central nervous system, of which 22 are novel. Furthermore, during development, specific TN-C isoforms were found to occur in distinct relative frequencies, as demonstrated for isoforms containing two alternatively spliced FNIII domains. We conclude that TN-C is expressed in a complex and regulated pattern in mouse central nervous system. These findings highlight the potential role of TN-C in mediating specific neuron glia interactions.
High energy femtosecond pulse compression (2016)

An original method for retrieving the Kerr nonlinear index was proposed and implemented for TF12 heavy flint glass. Then, a defocusing lens made of this highly nonlinear glass was used to generate an almost constant spectral broadening across a Gaussian beam profile. The lens was designed with spherical curvatures chosen in order to match the laser beam profile, such that the product of the thickness with intensity is constant. This solid-state optics in combination with chirped mirrors was used to decrease the pulse duration at the output of a terawatt-class femtosecond laser. We demonstrated compression of a 33 fs pulse to 16 fs with 170 mJ energy.
A discrete parameter HMM approach to on-line handwriting recognition (2002)

One area where on-line handwriting recognition technology is most critical is the domain of small portable platforms. Because such platforms have limited resources, it is not presently practical to consider a continuous parameterization for the hidden Markov models used in the recognition. On the other hand, discrete parameter techniques such as used in speech recognition are difficult to apply, because there is no well-understood handwriting equivalent to phonological rules. A possible solution is to extract this information directly from the data, by constructing an alphabet of sub-character, elementary handwriting units. The performance of this method is illustrated on a discrete handwriting recognition task with an alphabet of 81 characters.
Hepatitis A infection and primary hepatocellular carcinoma. (1979)

The prevalence of antibody to the hepatitis A antigen (anti-HAV) has been studied in Senegal, among patients suffering from primary hepatocellular carcinoma (PHC) and among healthy blood donors. Anti-HAV was found in 62.5% of 64 cases of PHC as compared to 64% of 50 blood donors. Anti-HAV was as prevalent among PHC patients who evidenced chronic hepatitis B infection as among those without markers of chronic hepatitis B infection. These data suggest that hepatitis A infection is not associated with PHC in Senegal.
Is the immunological noise of abnormal autoimmunity an independent risk factor for premature ovarian aging? (2009)

Even minimal evidence of abnormal autoimmune function ("immunological noise") seems to increase risk toward premature ovarian aging, often manifesting as infertility. Evidence of abnormal autoimmune function, such as increased CGG triple expansion sizes, in young women, therefore, warrants vigilance for development of prematurely diminished ovarian reserve and infertility.
<title>Mechanical reliability of 8-m class ULE glass telescope blanks during manufacturing</title> (1995)

The manufacture of 8m class ULE<SUP>TM</SUP> glass telescope mirror blanks involves multiple steps each of which can induce both stresses and flaws. To ensure the mechanical reliability of such large mirror blanks, both during and post-manufacturing, extreme care is required in the various process steps (including handling, grinding, finishing, and transportation) so as to limit the stress and flaw severity to below the threshold level for the specific surface finish. This paper examines the critical stress/time histories the blanks experience during manufacturing and their ability to initiate slow crack growth from grinding flaws. Two different surface finishes, namely 120 grit and 270/325 grit, with and without acid etching are characterized with respect to strength, flaw, and fatigue behavior. These data show that the 270/325 grit finish with acid etching is appropriate for the sagging step which imposes a static stress of 650 psi in the center region of the mirror blank over a two-week sag period. Similarly, the 120 grit surface finish is adequate for grinding, packaging, and transporting steps which impose a static stress of 435 psi in the support pad region for a three month period. These predictions, based on power law fatigue model, were verified by conducting static fatigue tests (at appropriate stress levels) on a large sample of 6 inch diameter ULE<SUP>TM</SUP> discs (with appropriate surface finish) at 25 degrees C and 100% RH. A comparison of strength distribution of the discs, before versus after static fatigue tests, showed no changes in strength indicating absence of slow crack growth at stresses and environment representative of manufacturing process. Such a verification is imperative for selecting appropriate surface finishes for the mirror blanks to ensure their mechanical reliability during manufacturing.
E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. (1993)

A class of helix-loop-helix (HLH) proteins, including E2A (E12 and E47), E2-2, and HEB, that bind in vitro to DNA sequences present in the immunoglobulin (Ig) enhancers has recently been identified. E12, E47, E2-2, and HEB are each present in B cells. The presence of many different HLH proteins raises the question of which of the HLH proteins actually binds the Ig enhancer elements in B cells. Using monoclonal antibodies specific for both E2A and E2-2, we show that both E2-2 and E2A polypeptides are present in B-cell-specific Ig enhancer-binding complexes. E2-box-binding complexes in pre-B cells contain both E2-2 and E2A HLH subunits, whereas in mature B cells only E2A gene products are present. We show that the difference in E2-box-binding complexes in pre-B and mature B cells may be caused by differential expression of E2A and E2-2.
Distributed Amplifiers: Practical Considerations and Experimental Results (1950)

The principle of distributed amplification has recently been proposed as a means for obtaining amplification with conventional vacuum tubes over very great bandwidths. Unlike conventional circuits, distributed amplifiers have an attainable gain-bandwidth product which is not limited by shunt capacitance associated with the vacuum tubes and circuit wiring. This paper cites experimental results which essentially corroborate the predictions based on first-order theory. It is pointed out that when extreme bandwidths are sought, these predicted characteristics are modified by several factors which are difficult to control in actual practice. Corrective methods are available, however, which permit a limited control over these modifying effects. These methods are discussed and their applications are illustrated by measurements on actual amplifiers with pass-bands on the order of 200 to 300 Mc.
Gian Gualberto Archi, Scritti di diritto romano (1986)

Jones Huguette. Gian Gualberto Archi, Scritti di diritto romano. In: L'antiquité classique, Tome 55, 1986. pp. 543-544.
Human Amniotic Fluid-Derived Mesenchymal Stem Cells As Therapeutic Vehicles: A Novel Approach For the Treatment of Bladder Cancer (2011)

Recent studies support cell-based therapies for cancer treatment. An advantageous cell type for such therapeutic schemes are the mesenchymal stem cells (MSCs) that can be easily propagated in culture, genetically modified to express therapeutic proteins, and exhibit an innate tropism to solid tumors in vivo. Recently, we successfully isolated and expanded MSCs from second-trimester amniotic fluid (AF-MSCs). The main characteristic of AF-MSCs is their efficient and rapid expansion in vitro. Herein, we investigated the AF-MSCs tropism and capability to transport interferon beta (IFNβ) to the region of neoplasia in a bladder tumor model. To this end, we used the T24M bladder cancer cell line, previously generated from our studies, and developed a disease progression model in immunosuppressed mice, that can recapitulate the molecular events of bladder carcinogenesis. Our results documented that AF-MSCs exhibited high motility, when migrated either to T24M cells or to T24M-conditioned medium, and we further identified and studied the secreted factors which may trigger these enhanced migratory properties. Further, lentivirus-transduced AF-MSCs, expressing green fluorescent protein (GFP) or IFNβ, were intravenously administered to T24M tumor-bearing animals at multiple doses to examine their therapeutic effect. GFP- and IFNβ-AF-MSCs successfully migrated and colonized at the tumor site. Notably, significant inhibition of tumor growth as well as prolonged survival of mice were observed in the presence of IFNβ-AF-MSCs. Collectively, these results document the great potential of AF-MSCs as anti-cancer vehicles, implemented by the targeting of the tumor site and further facilitated by their high proliferation rate and expansion efficiency in culture.
Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends. (2013)

Cell based regenerative therapy has emerged as one of the most promising options of treatment for patients suffering from heart failure. Various adult stem cells types have undergone extensive clinical trials with limited success which is believed to be more of a cytokine effect rather than cell therapy. Pluripotent human embryonic stem cells (hESCs) have emerged as an attractive candidate stem cell source for obtaining cardiomyocytes (CMs) because of their tremendous capacity for expansion and unquestioned potential to differentiate into CMs. Studies carried out in animal models indicate that ES-derived CMs can partially remuscularize infarcted hearts and improve contractile function; however, the effect was not sustained over long follow up periods due to their limited capacity of cell division in vivo. Thus, the concept of transplanting multipotent cardiovascular progenitors derived from ES cells has emerged since the progenitors retain robust proliferative ability and multipotent nature enabling repopulation of other myocardial elements also in addition to CMs. Transplantation of CMs (progenitors) seeded in biodegradable scaffold and gel based engineered constructs has met with modest success due to issues like cell penetration, nutrient and oxygen availability and inflammation triggered during scaffold degradation inversely affecting the seeded cells. Recently cell sheet based tissue engineering involving culturing cells on 'intelligent' polymers has been evolved. Generation of a 3-D pulsatile myocardial tissue has been achieved. However, these advances have to be looked at with cautious optimism as many challenges need to be overcome before using these in clinical practice.