gebhart/patrepeval huggingface dataset:
Cleavage of Ig-Hepta at a “SEA” Module and at a Conserved G Protein-coupled Receptor Proteolytic Site (2002)

Ig-Hepta is a member of a new subfamily of the heptahelical receptors and has an unusually long N terminus extending toward the extracellular side of the plasma membrane. Pulse-chase experiments in 293T cells using antisera specifically recognizing its N- and C-terminal regions demonstrated that Ig-Hepta is core-glycosylated cotranslationally and proteolytically processed into a two-chain form in the endoplasmic reticulum, followed by maturation of oligosaccharide chains and dimerization. The cleavage occurs at two highly conserved sites: one in a "SEA" module (a module first identified in sperm protein, enterokinase, and agrin) near the N terminus and the other in the stalk region preceding the first transmembrane span, generating approximately 20-, 130-, and 32-kDa fragments. The latter two remain tightly associated non-covalently even after cleavage as revealed by immunoprecipitation of native and myc-tagged Ig-Hepta constructs that were transiently expressed in 293T cells. The dimer consisting of four chains, (130 kDa + 32 kDa)(2), is linked by disulfide bonds. A fusion protein of the extracellular domain of Ig-Hepta and the Fc domain of immunoglobulin was found to be a good substrate of the processing enzymes and used for determining the exact cleavage sites in the SEA module and juxtamembrane stalk region.
골프 스트로크중 칩샷의 운동학적 분석 (2002)

본 연구의 목적은 8번 아이언으로 30M 거리를 칩 샷을 통한 3차원적 운동학적 분석을 통해서 칩 샷의 원리와 근거를 제시하여 골퍼들의 기초 자료를 제공하고자 하는데 그 목적을 두었다.
1. 선운동의 변인
스윙 소요시간에서는 숙련자가 1.083±0202sec.로 비숙련자는 1.217sec. 유의한 차이를 보였다(p<.05). event별로는 event 1에서만 유의하게 숙련자가 빠르게 나타났지만(p<.05), event 2,3에서는 차이를 보이지 않았다. 클럽헤드 속도에서는 event 3(p<.001), 4(p<.01)에서 비숙련자가 숙련자보다 빠르게 나타나 통계적으로 유의한 차이를 보였지만, event 1, 2에서는 차이를 보이지 않았다. 신체중심변위에서는 event 3에서만 숙련자가 비숙련자보다 중심이 낮게 형성되었고(p<.05). 나머지는 event 1, 2, 4에서는 차이를 보이지 않았다.
2. 관절운동의 변인
코킹각 변위에서는 event 2(p<.05), 3(p<.01)애소 통계적으로 유의한 차이를 보였고, event 1, 4에서는 차이를 보이지 않았다. 양 슬관절 각 변위에서는 오른쪽 슬관절의 event 1을 제외하고는 통계적으로 유의한 차이가 없었다. 고관절의 각 변위에서는 집단간의 통계적으로 유의한 차이가 없었다.
112. The course of autoxidation reactions in polyisoprenes and allied compounds. Part IX. The primary thermal oxidation product of ethyl linoleate (1945)

J. L. Bolland and H. P. Koch, J. Chem. Soc., 1945, 445 DOI: 10.1039/JR9450000445
Psicología deportiva: técnicas para mejorar la concentración (final) (2003)

Segunda parte del articulo sobre la concentracion deportiva. El articulo incluye dos ejercicios, uno para la relajacion y otro de repaso teorico sobre los diferentes aspectos del enfoque.
Ultrafast all-optical NOR gate based on intersubband and interband transitions (2005)

An architecture for ultrafast all-optical digital processing, particularly NOR gates, based on intersubband and interband transitions in semiconductor quantum wells is proposed. Proof-of-principle experimental results and their analysis are also shown using InGaAs-AlAsSb coupled double-quantum-well structures that allow operation at communication wavelengths.
Sublethal Effects of Chlorantraniliprole on Spodoptera litura (Lepidoptera: Noctuidae) Moth: Implication for Attract-And-Kill Strategy (2021)

The integrated use of plant-derived volatile attractants and synthetic insecticides in attract-and-kill programs is a useful tool for integrated pest management programs reducing pesticide input. Efficient alternative insecticides are critically needed to replace methomyl, which has been banned on cruciferous vegetables in China because it is also highly toxic to nontarget organisms. In the present study, among 15 commonly used insecticides were screened for toxicity against <i>S. litura</i> moths, where chlorantraniliprole, flubendiamide, and emamectin benzoate was found to have the highest levels of toxicity (LC<sub>50</sub> of 0.56, 3.85, and 6.03 mg a.i. L<sup>-1</sup> respectively). After exposure to the low lethal concentration LC<sub>50</sub> of chlorantraniliprole, fecundity of the moths was substantially reduced. Egg-hatching was lower for LC<sub>20</sub>- and LC<sub>50</sub>-treated moth pairs than for untreated control pairs. Net reproductive rate (<i>R</i><sub>0</sub>), intrinsic rate of increase (<i>r</i>), and finite rate of increase (<i>λ</i>) were significantly reduced in LC<sub>50</sub>♀ × LC<sub>50</sub>♂ cohorts. Larval mortality was significantly higher in subsequent generations in pairs of LC<sub>50</sub>-treated moths. Chlorantraniliprole, which was most toxic and had significant sublethal effects on moths, can be used as an alternative insecticide to methomyl in the attracticide for controlling <i>S. litura</i> moths, and the LC<sub>50</sub> indicated a high potential for efficacy in the control <i>S. litura</i> through attract-and-kill schemes.
Placebo-Controlled Trial of Cyclosporin-A in HIV-1 Disease: Implications for Solid Organ Transplantation (2002)

Objective: Earlier open-label clinical trials have provided conflicting data on the effects of cyclosporin-A (CsA) on the clinical course and immune status of patients with HIV disease. With the prospects for wider use of CsA in the setting of solid organ transplantation in HIV-infected persons, data on the safety and immunologic activity of this agent are needed. We report here the results of a randomized, double-blind, placebo-controlled trial to assess the safety and immunologic activity of CsA administration in early HIV disease. Methods: Twenty-eight patients with confirmed HIV infection, CD4 cell counts greater than 500 × 106/L, and plasma HIV RNA >600 copies/mL were randomized to receive 2 mg/kg of CsA (Neoral) twice daily or identical placebo for 12 weeks. Subjects were stratified for the presence or absence of stable concomitant antiviral therapy. The primary end point was the effect of therapy on immune activation as assessed by the levels of soluble interleukin-2 receptors. Secondary end points included safety and effects of treatment on plasma HIV RNA, CD4 cell count, and other markers of immune activation and function. Results: The low dose of CsA used in this study did not suppress immune activation or increase circulating CD4 cell counts. Delayed-type hypersensitivity responses were not affected; however, lymphocyte proliferative responses tended to decrease. CsA-treated patients experienced a small but significant rise in plasma HIV RNA levels. Conclusions: Low-dose CsA has no benefit in patients with stable early HIV disease, and its administration may be associated with an increase in plasma HIV RNA. The use of CsA in HIV-infected patients undergoing organ transplantation should be undertaken with caution
Primary Human T-Lymphotropic Virus Type III Infection (1985)

Primary infection with the human T-lymphotropic virus type III (HTLV-III) was documented in three patients by virus isolation during acute illness and concurrent or subsequent HTLV-III seroconversion. All patients had fevers, rigors, arthralgias, and myalgias. Additional symptoms included truncal maculopapular rash, urticaria, abdominal cramps, and diarrhea. Lymphocytic meningitis accompanied the febrile illness in two patients. The estimated incubation period was 4 to 6 weeks, and the symptoms lasted 2 to 3 weeks. Seroconversion occurred 8 to 12 weeks after presumed exposure and was manifested by a characteristic antibody response pattern. Physicians should consider the possibility of primary HTLV-III infection when evaluating patients who belong to one of the risk groups for the acquired immunodeficiency syndrome and who have prolonged febrile illnesses.
Nosocomial Infection by Gentamicin-Resistant <i>Streptococcus faecalis</i> (1987)

Enterococci with high-level resistance to gentamicin account for 55% of clinical isolates of enterococci found in patients at the Ann Arbor Veterans Administration Medical Center. We prospectively studied cultures obtained from all 100 patients hospitalized from 1 December 1985 through 23 January 1986 on the surgical and thoracic intensive care units and a general medical floor. Ten patients' cultures grew colonies of gentamicin-resistant enterococci--six after admission to the intensive care units and four after hospitalization on the medical ward. The initial sites of colonization were the rectal and perineal areas in seven patients, sternal wound in one, urine in one, and the rectal and perineal areas as well as urine after Foley catheter insertion in one. Nine patients died and three of the deaths were associated with enterococcal infection. The acquisition of resistant strains was associated with previous and more frequent exposure to antimicrobial agents, and with geographic clustering of patients. Resistant enterococci were isolated from the hands of hospital personnel and were frequently isolated from environmental surfaces. Nosocomial acquisition and interhospital spread of gentamicin-resistant enterococci was shown to have occurred when plasmid content was used as an epidemiologic marker.
Transmit/receive beamforming for MIMO radar with colocated antennas (2009)

We propose a new technique for multiple-input multiple-output (MIMO) radar with colocated antennas. The essence of the proposed technique is to partition the transmitting array into a number of subarrays that are allowed to overlap. Each subarray is used to coherently transmit a waveform which is orthogonal to the waveforms transmitted by other subarrays. Coherent processing gain can be achieved by designing a weight vector for each subarray to form a beam towards a certain direction in space. Moreover, the subarrays are combined jointly to form a MIMO radar resulting in higher resolution capabilities. Simulation results show the substantial improvements offered by the proposed technique as compared to previous techniques that validate its effectiveness.
pp125 <sup>FAK</sup> -Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk (1995)

Paxillin, a focal-adhesion-associated protein, becomes phosphorylated in response to a number of stimuli which also induce the tyrosine phosphorylation of the focal-adhesion-associated protein tyrosine kinase pp125FAK. On the basis of their colocalization and coordinate phosphorylation, paxillin is a candidate for a substrate of pp125FAK. We describe here conditions under which the phosphorylation of paxillin on tyrosine is pp125FAK dependent, supporting the hypothesis that paxillin phosphorylation is regulated by pp125FAK. pp125FAK must localize to focal adhesions and become autophosphorylated to induce paxillin phosphorylation. Phosphorylation of paxillin on tyrosine creates binding sites for the SH2 domains of Crk, Csk, and Src. We identify two sites of phosphorylation as tyrosine residues 31 and 118, each of which conforms to the Crk SH2 domain binding motif, (P)YXXP. These observations suggest that paxillin serves as an adapter protein, similar to insulin receptor substrate 1, and that pp125FAK may regulate the formation of signaling complexes by directing the phosphorylation of paxillin on tyrosine.
Inhibition of Bordetella pertussis and Bacillus anthracis adenylyl cyclases by polyadenylate and “P”-site agonists. (1990)

Inhibition of adenylyl cyclases from Bacillus anthrasis and Bordetella pertussis by polyadenylate and by the most potent "P"-site agonists was investigated. These bacterial adenylyl cyclases differed in their sensitivity to inhibition by nominal "P"-site agents and in the effect of divalent cations on this inhibition. The enzyme from Bordetella pertussis was relatively insensitive to inhibition by "P"-site agonists, exhibiting a rank order of potency of 2'd3'AMP greater than 3'-AMP greater than 2',5'-ddAdo approximately Ado approximately 2'-dAdo, with IC50 values for 2'd3'AMP and 3'-AMP of 1-3 mM. Inhibition by 2'd3'AMP, however, was not affected by divalent cation, making it distinct from "P"-site-mediated inhibition of most mammalian adenylyl cyclases. The sensitivity to these nucleosides was comparable with potency for inhibition of bovine sperm adenylyl cyclase but was 3 orders of magnitude less potent than for activated enzyme from bovine or rat brain. The Bordetella pertussis enzyme was similarly insensitive to inhibition by polyadenylate, with 16 microM inhibiting less than 20%. By comparison, Bacillus anthrasis adenylyl cyclase was more potently inhibited by 2'd3'AMP (IC50 approximately 85 microM) but not by the other nucleosides (less than 15% inhibition at 1 mM), and inhibition by 2'd3'AMP was optimally enhanced by 5-10 mM Mg2+ or Mn2+, as is typical for inhibition by "P"-site agonists. The Bacillus anthrasis enzyme was potently inhibited by polyadenylate (IC50 approximately 0.3 microM), comparable to inhibition of brain adenylyl cyclases. Sensitivity of Bacillus anthrasis adenylyl cyclase to poly(A) was diminished somewhat by Ca2+/calmodulin (to IC50 approximately 1 microM) although Ca2+/calmodulin was without effect on inhibition by 2'd3'AMP. In contrast to inhibition of mammalian adenylyl cyclases via the "P"-site, inhibition of both bacterial adenylyl cyclases by 2'd3'AMP was competitive with respect to substrate MgATP. The data indicate basic differences in susceptibilities of these bacterial adenylyl cyclases to inhibition by poly(A), by adenosine analogs, and the effects of divalent cations. Although the potency of 2'd3'AMP and the metal-dependent nature of inhibition of Bacillus anthrasis adenylyl cyclase shared characteristics of "P"-site-mediated inhibition, the fact that inhibition of both bacterial adenylyl cyclases was competitive with respect to substrate strongly suggests that this inhibition was at the catalytic site and that these bacterial enzymes do not contain a distinct "P"-site.
Self-Supervised Classification for Planetary Rover Terrain Sensing (2007)

Autonomous mobility in rough terrain is key to enabling increased science data return from planetary rover missions. Current terrain sensing and path planning approaches can be used to avoid geometric hazards, such as rocks and steep slopes, but are unable to remotely identify and avoid non-geometric hazards, such as loose sand in which a rover may become entrenched. This paper proposes a self-supervised classification approach to learning the visual appearance of terrain classes which relies on vibration-based sensing of wheel-terrain interaction to identify these terrain classes. Experimental results from a four-wheeled rover in Mars analog terrain demonstrate the potential for this approach.
Improvements to the Sequence Memoizer (2010)

The sequence memoizer is a model for sequence data with state-of-the-art performance on language modeling and compression. We propose a number of improvements to the model and inference algorithm, including an enlarged range of hyperparameters, a memory-efficient representation, and inference algorithms operating on the new representation. Our derivations are based on precise definitions of the various processes that will also allow us to provide an elementary proof of the "mysterious" coagulation and fragmentation properties used in the original paper on the sequence memoizer by Wood et al. (2009). We present some experimental results supporting our improvements.
A Study for Implementation of HMIPv6 in all-IP WDM-PON (2008)

In this paper, we propose the next-generation broadband wireless access network architecture, which is based on the wavelength division multiplexing-passive optical network(WDM-PON), and efficient mobility management scheme to support quality-of-service(QoS) of multimedia services in the next-generation wireless network. By adapting WDM-PON technology to wireless access network, the proposed scheme can realize broadband wireless access network. In addition, We utilize newly proposed local channels between optical network units(ONUs) or subnets in order to support the fast and efficient local data and handoff data transmission. We evaluate the performance of the proposed scheme in terms of handoff delay and packet loss thru computer simulation. Thru various computer simulation results, we verified the superior performance of the proposed scheme by comparing with the results of other schemes.
Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells. (1992)

alpha-Thrombin, a G-protein-coupled receptor agonist, is mitogenic for neonatal vascular smooth muscle (VSM) cells, but it also causes secretion of the tyrosine kinase-coupled receptor agonist platelet-derived growth factor (PDGF). In order to determine the role of growth factors with tyrosine kinase-coupled receptors in thrombin's mitogenic signal transduction cascade, the synergistic effect of basic fibroblast growth factor (bFGF) in this system was examined. While bFGF itself is a growth factor for VSM cells, it causes a 1.7-fold synergistic effect when added together with thrombin. Herbimycin A, a specific tyrosine kinase inhibitor, both decreases thrombin-induced mitogenesis by greater than 90% and abolishes tyrosine phosphorylation of phospholipase C (PLC)-gamma-1. The magnitude and time course of the increase in intracellular free calcium concentration in response to thrombin is comparable in both the presence and absence of herbimycin A. These results provide evidence that herbimycin A specifically inhibits PLC-gamma-1 tyrosine phosphorylation without affecting VSM cell viability or calcium release. Furthermore, tyrosine phosphorylation is a necessary step in thrombin's mitogenic signal transduction cascade, but it is not essential for thrombin-induced release of calcium from intracellular stores. These data suggest that a tyrosine kinase, possibly supplied by the bFGF receptor, plays an essential role in thrombin-induced mitogenesis.
Tunable triple-wavelength mode-locked fiber laser with topological insulator Bi<sub>2</sub>Se<sub>3</sub>solution (2016)

We experimentally demonstrated a tunable triple-wavelength mode-locked erbium-doped fiber laser with few-layer topological insulator: Bi2Se3/polyvinyl alcohol solution. By properly adjusting the pump power and the polarization state, the single-, dual-, and triple-wavelength mode-locking operation could be stably initiated with a wavelength-tunable range (∼1 nm) and a variable wavelength spacing (1.7 or 2 nm). Meanwhile, it exhibits the maximum output power of 10 mW and pulse energy of 1.12 nJ at the pump power of 175 mW. The simple, low-cost triple-wavelength mode-locked fiber laser might be applied in various potential fields, such as optical communication, biomedical research, and sensing system.
The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments (1998)

The Arp2/3 complex is a stable assembly of seven protein subunits including two actin-related proteins (Arp2 and Arp3) and five novel proteins. Previous work showed that this complex binds to the sides of actin filaments and is concentrated at the leading edges of motile cells. Here, we show that Arp2/3 complex purified from Acanthamoeba caps the pointed ends of actin filaments with high affinity. Arp2/3 complex inhibits both monomer addition and dissociation at the pointed ends of actin filaments with apparent nanomolar affinity and increases the critical concentration for polymerization at the pointed end from 0.6 to 1.0 microM. The high affinity of Arp2/3 complex for pointed ends and its abundance in amoebae suggest that in vivo all actin filament pointed ends are capped by Arp2/3 complex. Arp2/3 complex also nucleates formation of actin filaments that elongate only from their barbed ends. From kinetic analysis, the nucleation mechanism appears to involve stabilization of polymerization intermediates (probably actin dimers). In electron micrographs of quick-frozen, deep-etched samples, we see Arp2/3 bound to sides and pointed ends of actin filaments and examples of Arp2/3 complex attaching pointed ends of filaments to sides of other filaments. In these cases, the angle of attachment is a remarkably constant 70 +/- 7 degrees. From these in vitro biochemical properties, we propose a model for how Arp2/3 complex controls the assembly of a branching network of actin filaments at the leading edge of motile cells.
Colecistectomía con un trócar asistida por imanes de neodimio. Reporte de un caso (2007)

Antecedentes: Los beneficios de la cirugia videolaparoscopica tradicional pueden ser mejorados con tecnicas cada vez menos invasivas que reducen la agresion parietal y el riesgo de complicaciones por trocares. Objetivo: Comunicar un caso de colecistectomia laparoscopica con trocar unico a nivel umbilical y asistencia de dispositivos quirurgicos magneticos en el tratamiento de litiasis vesicular. Lugar de aplicacion: Sanatorio de la Trinidad Mitre. Ciudad Autonoma de Buenos Aires, Argentina. Poblacion: Reporte de un caso. Resultado: Se realizo esta tecnica en una paciente, con diagnostico de litiasis vesicular sintomatica. Morbilidad 0%. Mortalidad 0%. Internacion 24 h. Optimo resultado estetico. Seguimiento a un mes. Conclusion: Con la asistencia de los dispositivos quirurgicos magneticos, hemos logrado realizar traccion y contratraccion de la vesicula, para la colecistectomia con un solo trocar, reproduciendo los pasos de la colecistectomia laparoscopica tradicional. Creemos que estos dispositivos, seran de gran utilidad al tiempo de realizar «cirugias sin cicatriz»
Dynamic Shortest Paths Containers (2004)

Using a set of geometric containers to speed up shortest path queries in a weighted graph has been proven a useful tool for dealing with large sparse graphs. Given a layout of a graph G=(V,E), we store, for each edge (u,v)∈E, the bounding box of all nodes t∈V for which a shortest u-t-path starts with (u,v). Shortest path queries can then be answered by Dijkstraś restricted to edges where the corresponding bounding box contains the target. In this paper, we present new algorithms as well as an empirical study for the dynamic case of this problem, where edge weights are subject to change and the bounding boxes have to be updated. We evaluate the quality and the time for different update strategies that guarantee correct shortest paths in an interesting application to railway information systems, using real-world data from six European countries.
Characterization and Functional Activity of Murine Monoclonal Antibodies Specific for α1,6-Glucan Chain of Helicobacter pylori Lipopolysaccharide (2011)

Anti-α1,6-glucan mAbs could have potential application in typing and surveillance of H. pylori isolates as well as offer insights into structural requirements for the development of LPS-based vaccine against H. pylori infections.