gebhart/patrepeval huggingface dataset:
Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase (1997)

Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly elutriated human monocytes, we examined the effect on PGHS-2 expression of certain cytokine-suppressive anti-inflammatory drugs such as SK&F 86002. Incubation with serum-treated zymosan (STZ) stimulated the expression of PGHS-2 in a time- and dose-dependent manner. SK&F 86002 dose-dependently inhibited this STZ-induced expression of PGHS-2 protein, which correlated with a decrease in prostaglandin E2 and thromboxane A2 production. However, suppression of PGHS-2 expression is not the result of suppressed cytokine production, because SK&F 86002 suppressed PGHS-2 expression initiated by IL-1beta and TNF-alpha, in addition to other stimuli. Moreover, this effect was selective in that the protein expression of two other important enzymes involved in the metabolism of arachidonic acid, cytosolic phospholipase A2 and 5-lipoxygenase, was not affected. Stimulation with STZ caused a time-dependent increase in levels of PGHS-2 mRNA; incubation with cytokine-suppressive agents caused a decrease of these levels, suggesting the involvement of transcription and/or mRNA stability events in the inhibition of PGHS-2. These results indicate a new and potentially important anti-inflammatory property of SK&F 86002, namely the specific suppression of PGHS-2 induction.
Analysis of effective power budget in optical bus and star networks using erbium-doped fiber amplifiers (1993)

The use of erbium-doped fiber optical amplifiers (EDFAs) in bus and star networks is studied. The number of stations that can be supported with and without amplifiers in a single folded bus, a double bus, and a star is determined. For a typical case, when only one station on the bus is allowed to transmit at a time, as is the case in a time-division multiplexed network, the number of stations that can be supported with amplifiers is on the order of several thousands. This number drops to less than a thousand when all stations are allowed to transmit simultaneously on different channels in a wavelength-division multiplexed network, because of amplifier gain saturation. In the former case, the bus has the potential to outperform the star, but in the latter case, the star topology is still better.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
In Situ Assessment of Pitting Corrosion and Its Inhibition Using a Localized Corrosion Monitoring Technique (2010)

Pitting corrosion of pipelines remains a serious concern to operators in the oil and gas industry. Pitting is a particularly insidious and extremely rapid form of attack of a metal structure that can lead to unexpected system failures. The pipe wall can be perforated within a relatively short space of time with no appreciable metal loss on the pipeline as a whole. Corrosion inhibitors are widely used by operators to maintain asset integrity, and their effect on controlling general corrosion to acceptable levels is easily demonstrated by the use of weight-loss coupons or techniques such as linear polarization resistance (LPR). However, up to 80% of pipeline failures are ascribed to pitting, but very few monitoring methods are capable to show this outcome. This paper discusses a localized corrosion monitoring (LCM) technique, which has been utilized to provide in situ quantitative assessment of pitting corrosion under laboratory-simulated wet sour gas operating conditions. The predicted pitting damage by LCM was subsequently verified using a calibrated white light interferometer (WLI). Examples of the assessment of corrosion inhibitors in terms of their pitting inhibition performance using LCM and the WLI are provided. It should be noted that the primary purpose of this paper is not to evaluate the performance of corrosion inhibitors per se but the selected examples in this paper are to illustrate the capability of LCM in providing qualitative and quantitative information of pitting corrosion under laboratory testing conditions.
Prediction-Based QoS Management for Real-Time Data Streams (2006)

With the emergence of large wired and wireless sensor networks, many real-time applications need to operate on continuous unbounded data streams. At the same time, many of these systems have inherent timing constraints. Providing deadline guarantees for queries over dynamic data streams is a challenging problem due to bursty data stream arrival rates and time-varying stream contents. In this paper, we propose a prediction-based quality-of-service (QoS) management scheme for periodic queries over dynamic data streams. Our QoS management scheme features novel query workload estimators, which predict the query workload using execution time profiling and input data sampling, and adjusts the query QoS levels based on online query execution time prediction. We implement our QoS management algorithm on a real-time data stream query system prototype called RTStream. Our experimental evaluation of the scheme shows that our query workload estimator performs very well even with workload fluctuations and our QoS management scheme yields better overall system utility than the existing approaches for QoS management
Analysis of slot coupling in a radial line slot antenna for DBS reception (1990)

A radial line slot antenna (RLSA) is a nonresonant multimode waveguide slotted array. The slot coupling to the radial waveguide in this antenna is analysed. A parallel plate waveguide with a periodic boundary condition is used to simulate a sectral region of the circular aperture in a RLSA. A set of integral equations for the fields in the slot is derived, based on the field equivalence theorem, and is solved numerically by Galerkin's method. Theoretical results effectively express the measured effects of the various antenna design parameters on the slot coupling.
SPATIAL DIMENSION OF RELIGIOUS EXPERIENCE (2018)

This article discusses the spatial dimension of the religious experience between candomblecistas and evangelicals, which involves these agents' spatial practices and equally, their representations of space. This is done by establishing a parallel between Mythical Geography and Prophetic Geography with Candombl (Terreiro do Cobre) and Neo-Pentecostalism (Universal Church of the Kingdom of God), respectively. These geographies (Mythical and Prophetic) were described by Dardel ( It is these modes of relationship with space -synthesized in the concept of geographicity -that are discussed based on distinct creeds in which different ways of perceiving, representing and acting in reality are presented through two symbolic forms (CASSIRER, 1994), that of myth -which substantiates a Mythical Geography -and that of religion -which in turn gives rise to a Prophetic Geography.
PARP inhibitor olaparib increases the oncolytic activity of dl922‐947 in in vitro and in vivo model of anaplastic thyroid carcinoma (2014)

PARP inhibitors are mostly effective as anticancer drugs in association with DNA damaging agents. We have previously shown that the oncolytic adenovirus dl922-947 induces extensive DNA damage, therefore we hypothesized a synergistic antitumoral effect of the PARP inhibitor olaparib in association with dl922-947. Anaplastic thyroid carcinoma was chosen as model since it is a particularly aggressive tumor and, because of its localized growth, it is suitable for intratumoral treatment with oncolytic viruses. Here, we show that dl922-947 infection induces PARP activation, and we confirm in vitro and in vivo that PARP inhibition increases dl922-947 replication and oncolytic activity. In vitro, the combination with olaparib exacerbates the appearance of cell death markers, such as Annexin V positivity, caspase 3 cleavage, cytochrome C release and propidium iodide permeability. In vivo, we also observed a better viral distribution upon PARP inhibition. Changes in CD31 levels suggest a direct effect of olaparib on tumor vascularization and on the viral distribution within the tumor mass. The observation that PARP inhibition enhances the effects of dl922-947 is highly promising not only for the treatment of anaplastic thyroid carcinoma but, in general, for the treatment of other tumors that could benefit from the use of oncolytic viruses.
A facile in situ generation of dithiocarbamate ligands for stable gold nanoparticle–oligonucleotide conjugates (2008)

Here we demonstrate a facile strategy of preparing gold nanoparticle (AuNP) and DNA conjugates by in situ generation of strong metal affinity capping ligands, dithiocarbamates (DTC) modified oligonucleotides; the conjugates produced are stable at elevated temperature, resistant to ligand displacement and preserve the functionality of the conjugated oligonucleotides.
Run-time support for distributed sharing in safe languages (2003)

We present a new run-time system that supports object sharing in a distributed system. The key insight in this system is that a handle-based implementation of such a system enables efficient and transparent sharing of data with both fine- and coarse-grained access patterns. In addition, it supports efficient execution of garbage-collected programs. In contrast, conventional distributed shared memory (DSM) systems are limited to providing only one granularity with good performance, and have experienced difficulty in efficiently supporting garbage collection. A safe language, in which no pointer arithmetic is allowed, can transparently be compiled into a handle-based system and constitutes its preferred mode of use. A programmer can also directly use a handle-based programming model that avoids pointer arithmetic on the handles, and achieve the same performance but without the programming benefits of a safe programming language. This new run-time system, DOSA (Distributed Object Sharing Architecture), provides a shared object space abstraction rather than a shared address space abstraction. The key to its efficiency is the observation that a handle-based distributed implementation permits VM-based access and modification detection without suffering false sharing for fine-grained access patterns. We compare DOSA to TreadMarks, a conventional DSM system that is efficient at handling coarse-grained sharing. The performance of fine-grained applications and garbage-collected applications is considerably better than in TreadMarks, and the performance of coarse-grained applications is nearly as good as in TreadMarks. Inasmuch as the performance of such applications is already good in TreadMarks, we consider this an acceptable performance penalty.
Virtual Screening Identifies Novel Sulfonamide Inhibitors of <i>ecto</i>-5′-Nucleotidase (2012)

We aimed to identify inhibitors of ecto-5'-nucleotidase (ecto-5'-NT, CD73), a membrane-bound metallophosphoesterase that is implicated in the control of purinergic receptor signaling and a number of associated therapeutically relevant effects. Currently, only very few compounds, including ADP, its more stable analogue α,β-methylene-ADP, ATP, and anthraquinone derivatives are known to inhibit this enzyme. In the search for inhibitors with more drug-like properties, we applied a model structure-based virtual screening approach augmented by chemical similarity searching. On the basis of this analysis, 51 candidate compounds were finally selected for experimental evaluation. A total of 13 of these molecules were confirmed to have competitive inhibitory activity. The most potent inhibitor, 6-chloro-2-oxo-N-(4-sulfamoylphenyl)-2H-chromene-3-carboxylic acid amide (17), showed an IC(50) value of 1.90 μM. In contrast to the nucleotide- and anthraquinone-derived antagonists, the newly identified competitive inhibitors are uncharged at physiological pH values, possess a drug-like structure, and are structurally distinct from known active compounds.
Efficient Continuous Production of Cellobiose by Hydrolysis of Crystalline Cellulose with Cellulase. (2000)

Trichoderma viride起源のセルラーゼ標品より1段階のカラムクロマトグラフィーで, ほぼ完全にβ-glucosidase活性の除去されたセルラーゼ活性画分 (PEAK I) が得られた. PEAK IをMCCの連続加水分解実験に供した. PEAK I (3.0g/l) を槽内に保持できる反応槽内へ, MCC懸濁液 (55.0g/l) を連続的に供給 (12.8mg MCC/h) しながら, MCCの加水分解を行った. その結果, 反応168～576時間の間で定常状態が得られ, セロビオース濃度は約3.5～3.0g/l, セロビオース含有率は75%, およびセロビオース/グルコースは3.0であった. その上, セロビオース収率は60%であった. これらの値は既往の実験値と比較して, いずれも相当に高い値であった. 本実験におけるMCCの連続加水分解系は生成物が連続的に反応槽外に取り出されるのでセロビオースのグルコースへの分解が抑えられること, および, 反応中の酵素の失活がほとんどないので, 酵素の損失が少ないことなどの利点を有する.
Processing fruits : science and technology (2005)

PART I: BIOLOGY, PRINCIPLES AND APPLICATIONS. Classification, Composition of Fruits, and Postharvest Maintenance of Quality. Refrigerated and Controlled Modified Atmosphere Storage. Fresh-Cut Fruit. Juice Processing. Enzymes in the Fruit Juice and Wine Industry. Fruit Preserves and Jams. Drying of Fruits. Fruit Freezing. Thermal Processing of Fruits: I. Non-Thermal Processing of Fruits: II. Ionizing Radiation for Preservation of Fruits. Microbiology of Fruit Products. Direct Food Additives in Fruit Processing. Quality Assurance, Quality Control, Inspection, and Sanitation. Packaging of Fruits and Vegetables. Grades, Standards, and Food Labeling. Residual Management in Fruit Processing Plants. PART II: MAJOR PROCESSED PRODUCTS. Apples and Apple Processing. Apricots and Peaches. Cherry and Sour Cherry Processing. Plums and Prunes. Strawberries and Raspberries. Processing in Cranberry, Blueberry, Currant, and Gooseberry. Grape Juice: Factors that Influence Quality, Processing Technology, and Economics. Raisin Production and Processing. Oranges and Tangerines. Grapefruits, Lemons, and Limes. Pineapples. Bananas (Processed). Tropical Fruits. Coconuts. Avocados. Olives. Nuts.
Selective Complexation of <i>N‐</i>Alkylpyridinium Salts: Binding of NAD<sup>+</sup> in Water (2004)

A new class of receptor molecules is presented that is highly selective for N-alkylpyridinium ions and electron-poor aromatics. Its key feature is the combination of a well-preorganized molecular clip with an electron-rich inner cavity and strategically placed, flanking bis-phosphonate monoester anions. This shape and arrangement of binding sites attracts predominantly flat electron-poor aromatics in water, binds them mainly by pi-cation, pi-pi, CH-pi, and hydrophobic interactions, and leads to their highly efficient desolvation. NAD(+) and NADP, the important cofactors of many redox enzymes, are recognized by the new receptor molecule, which embraces the catalytically active nicotinamide site and the adenine unit. Even nucleosides such as adenosine are likewise drawn into the clip's cavity. Complex formation and structures were examined by one- and two-dimensional NMR spectroscopy, Job plot analyses, and isothermal titration microcalorimetric (ITC) measurements, as well as quantum chemical calculations of (1)H NMR shifts. The new receptor molecule is a promising tool for controlling enzymatic oxidation processes and for DNA chemistry.
Optimal sequential linear interpolation applied to nonlinear color transformations (2002)

Introduces a new approach which we call sequential linear interpolation (SLI) for interpolating multidimensional nonlinear functions. SLI grid points can be nonuniformly placed. By applying asymptotic analysis, we obtain optimal conditions for placing the interpolation grid points in the SLI grid structure to minimize the interpolation error. Thus, we use the grid points more efficiently. We apply this technique to the color printer calibration problem where highly nonlinear functions must be efficiently implemented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Identification of Essential Amino Acid Residues of the NorM Na <sup>+</sup> /Multidrug Antiporter in <i>Vibrio parahaemolyticus</i> (2005)

NorM is a member of the multidrug and toxic compound extrusion (MATE) family and functions as a Na+/multidrug antiporter in Vibrio parahaemolyticus, although the underlying mechanism of the Na+/multidrug antiport is unknown. Acidic amino acid residues Asp32, Glu251, and Asp367 in the transmembrane region of NorM are conserved in one of the clusters of the MATE family. In this study, we investigated the role(s) of acidic amino acid residues Asp32, Glu251, and Asp367 in the transmembrane region of NorM by site-directed mutagenesis. Wild-type NorM and mutant proteins with amino acid replacements D32E (D32 to E), D32N, D32K, E251D, E251Q, D367A, D367E, D367N, and D367K were expressed and localized in the inner membrane of Escherichia coli KAM32 cells, while the mutant proteins with D32A, E251A, and E251K were not. Compared to cells with wild-type NorM, cells with the mutant NorM protein exhibited reduced resistance to kanamycin, norfloxacin, and ethidium bromide, but the NorM D367E mutant was more resistant to ethidium bromide. The NorM mutant D32E, D32N, D32K, D367A, and D367K cells lost the ability to extrude ethidium ions, which was Na+ dependent, and the ability to move Na+, which was evoked by ethidium bromide. Both E251D and D367N mutants decreased Na+-dependent extrusion of ethidium ions, but ethidium bromide-evoked movement of Na+ was retained. In contrast, D367E caused increased transport of ethidium ions and Na+. These results suggest that Asp32, Glu251, and Asp367 are involved in the Na+-dependent drug transport process.
RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells (2007)

Retinoids are used for treatment of acute promyelocytic leukemia (APL). Am-80, Tamibarotene, binds to retinoic acid receptor alpha (RARalpha) more specifically than all-trans retinoic acid. We studied the tumor cell suppressive effects of Am-80, with respect to cytotoxicity and growth inhibition using eight myeloid and lymphoid malignant cells in culture (HL-60, HL-60R, K-562, Kasumi-1, MEG01, Raji, U266B1, and U937). The effects of Am-80 were examined during 9 days of incubation with 10(-7)-10(-5) M of Am-80 in culture medium, which was changed every 3 days. HL-60 were the only cells sensitive to Am-80-induced cytotoxicity; the latter reached more than 95% after 9 days of incubation, and death was primarily through apoptosis. The total mass of RARalpha in HL-60 was significantly greater (p<0.006) than in ATRA-resistant HL-60 (HL-60R) as well as all of other cells tested. However, in all cells excluding HL-60, Am-80 induced time- and dose-dependent cell growth inhibition without noticeable cytotoxicity. TGF-beta2 was released into the media containing cells incubated with Am-80 for 3 days. A dose-dependent increment of phosphorylation of Smad-2 was also detected. The relative amount of secreted TGF-beta2 correlated with the growth inhibition rates in all cells tested excluding HL-60, and with the total mass of RARalpha in the cells (p=0.0137). Our results indicate that Am-80-induced cell-type non-specific growth inhibition is mediated by TGF-beta2, where the total mass of RARalpha could be an important regulatory factor in hematologic malignant cells.
Separation of Blended Data by Iterative Denoising (2012)

Seismic acquisition is a trade-off between economic and quality. Conventional acquisition surveys are designed such that the time intervals between shots are sufficiently large to avoid the interference of different source response. Recently a great change of mindset in seismic acquisition has occurred and much attention has been drawn to blended acquisition, where different sources are shot in an overlapping fashion, so that both efficiency and image quality can be significantly improved. Deblending is the procedure of recovering data as if they were acquired in the conventional way. A simple least-squares procedure is only able to get pseudodeblend results, which cannot removed the blending noise. We already know that this noise is coherent in the common source domain, but incoherent in other domains. For this character, deblending using coherence-pass filter was proposed. However while dealing with high source density ratio blended data, separation results are usually not satisfactory. Based on the previous research, a new method to separate blended data by iterative denoising is introduced. When applied to a numerically blend field dataset of high source density ratio, both separation results and calculation efficiency are largely improved.
An accelerated convergent ordered subsets algorithm for emission tomography (2004)

We propose an algorithm, E-COSEM (enhanced complete-data ordered subsets expectation-maximization), for fast maximum likelihood (ML) reconstruction in emission tomography. E-COSEM is founded on an incremental EM approach. Unlike the familiar OSEM (ordered subsets EM) algorithm which is not convergent, we show that E-COSEM converges to the ML solution. Alternatives to the OSEM include RAMLA, and for the related maximum a posteriori (MAP) problem, the BSREM and OS-SPS algorithms. These are fast and convergent, but require ajudicious choice of a user-specified relaxation schedule. E-COSEM itself uses a sequence of iteration-dependent parameters (very roughly akin to relaxation parameters) to control a tradeoff between a greedy, fast but non-convergent update and a slower but convergent update. These parameters are computed automatically at each iteration and require no user specification. For the ML case, our simulations show that E-COSEM is nearly as fast as RAMLA.
Tapered 47 μm quantum cascade lasers with highly strained active region composition delivering over 45 watts of continuous wave optical power (2012)

A strain-balanced, Al0.7In0.22As/In0.72Ga0.28As/InP quantum cascade laser structure, designed for light emission at 4.7µm using the non-resonant extraction design approach, was grown by molecular beam epitaxy. Laser devices were processed in tapered buried heterostructure geometry and then mounted on AlN/SiC composite submounts using hard solder. A 10 mm long laser with 7.5µm-wide central section tapered up to 20µm at laser facets generated over 4.5W of single-ended CW/RT optical power at 283K. Maximum wallplug efficiency of 16.3% for this laser was reached at 4W level. Reliability of over 2,000h has been demonstrated for an air-cooled system delivering optical power of 3W in a collimated beam with overall system efficiency exceeding 10%.