gebhart/patrepeval huggingface dataset:
The Decreased Susceptibility of Bcr/Abl Targets to NK Cell-Mediated Lysis in Response to Imatinib Mesylate Involves Modulation of NKG2D Ligands, GM1 Expression, and Synapse Formation (2006)

Chronic myeloid leukemia is a clonal multilineage myeloproliferative disease of stem cell origin characterized by the presence of the Bcr/Abl oncoprotein, a constitutively active tyrosine kinase. In previous studies, we have provided evidence that Bcr/Abl overexpression in leukemic cells increased their susceptibility to NK-mediated lysis by different mechanisms. In the present study, using UT-7/9 cells, a high level Bcr/Abl transfectant of UT-7 cells, we show that the treatment of Bcr/Abl target by imatinib mesylate (IM), a specific Abl tyrosine kinase inhibitor, hampers the formation of the NK/target immunological synapse. The main effect of IM involves an induction of surface GM1 ganglioside on Bcr/Abl transfectants that prevents the redistribution of MHC-related Ag molecules in lipid rafts upon interaction with NK cells. IM also affects cell surface glycosylation of targets, as assessed by binding of specific lectins resulting in the subsequent modulation of their binding to lectin type NK receptor, particularly NKG2D. In addition, we demonstrate that the tyrosine kinase activity repression results in a decrease of MHC-related Ags-A/B and UL-16-binding protein expression on Bcr/Abl transfectants UT-7/9. We show that NKG2D controls the NK-mediated lysis of UT-7/9 cells, and IM treatment inhibits this activating pathway. Taken together, our results show that the high expression of Bcr/Abl in leukemic cells controls the expression of NKG2D receptor ligands and membrane GM1 via a tyrosine kinase-dependent mechanism and that the modulation of these molecules by IM interferes with NK cell recognition and cytolysis of the transfectants.
Transmission loss of coated single-mode fiber at low temperatures (1980)

Coated single-mode fibers with various coating thicknesses were manufactured, and loss increases due to cooling were measured. It was found that the excess loss increases steeply in the small V-value region at low temperatures. A simple model for fiber bends in the coating was introduced, and the increases in loss were related to the strain resulting from use of the model. It would appear that the axial compressive strain has a serious influence on the loss increases. A suitable silicone buffer layer for preventing loss increases has been determined. The selected silicone layer diameter is 0.45 mm for a 0.9-mm nylon outer layer diam.
MOCVD for PZT thin films by using novel metalorganic sources (2002)

The authors describe an MOCVD (metal-organic chemical vapor deposition) method for forming PZT thin films using novel metal-organic source materials. Bisdipivaloylmethanato lead, zirconium-t-butoxide, and titanium tetra-i-propoxide were used as source materials. PZT thin films were formed by the thermal oxidation of the vapor of these source materials with oxygen, at a temperature ranging from 600 to 700 degrees C under a reduced pressure ranging from 1 to 2 Torr. Perovskite structures with well-developed crystalline grains were obtained on Pt
On the uniform strong approximation of Marcinkiewicz type for multivariable continuous functions (2005)

The rate of uniform strong approximation of Marcinkiewicz type for multivariable continuous functions is obtained in this paper as follows: $$\parallel \frac{1}{{k + 1}}\sum\limits_{j = 0}^k {|S_j (f) - f|^q } \parallel \leqslant \frac{C}{{k + 1}}\sum\limits_{j = 0}^k {E_j^q (f),} $$ where Sj(f) denotes the square partial Fourier sum of f and Ej(f) denotes the square best approximation of f by trigonometric polynomials of degree (j,j,…,j), j=0,1,2,…
Positive inotropic effect of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1 -piperazinyl]-2(1H)-quinolinone (OPC-8212) and mechanism of action in guinea pig ventricular myocardium. (1984)

Effects of 3,4-dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- qu inolinone ( OPC -8212) on the isolated guinea-pig ventricular myocardium was studied measuring the force of contraction and action potential under various experimental conditions. The positive inotropic effect (PIE) of OPC -8212 was observed at a concentration higher than 10(-5) mol/l. The following circumstantial evidence led to the conclusion that OPC -8212 caused an elevated cyclic AMP level in myocardial cells thereby producing the positive inotropic effect. The positive inotropic effect of OPC -8212 was unaffected by reserpinization, propranolol and cimetidine treatments. OPC -8212 strengthened the slow response of partially depolarized papillary muscle. This suggested an increased calcium influx across myocardial cell membrane. Carbachol inhibited the positive inotropic effect of OPC -8212 on ventricular myocardium. Concentration-effect curves for isoprenaline (isoproterenol) and histamine were shifted to the left but that for dihydro-ouabain was not affected at all by OPC -8212. Rested-state contraction of guinea-pig papillary muscle was strengthened by OPC -8212 the same as dibutyryl cyclic AMP and beta-agonists.
The variability of dynamic coefficient of friction material in flexible packaging (2018)

Appropriate labeling and flexible packaging plays an important role on the today`s demands. There is diverse possibilities especially related to polymeric materials. Flexible packaging means to consider options such as OPP (Oriented Polypropylene), PVC (Polyvinyl Chloride), OPS (Oriented Polystyrene), PET (Polyethylene Terephthalate) or all kind of self-adhensive paper and foil types. Special highlight are the "Shrink Sleeve" labels that meet the most demanding market challenges. Its capabilities are beneficial. Laminated packaging materials are functional. Both constitute protection and packaging capacity. Coefficient of friction is the value that serves to meet the standard of how the flexible packaging material will glide and move on the packaging machine. This research is focused on the optimum quality of the packaging production process to meet all the preconditions for implementation of the semifinished product packaging and to avoid difficulties and possible stoppages on the packaging machine itself.
<b>Dexamethasone suppresses cochlear Hes1 expression after noise exposure</b> (2012)

Noise exposure for 3 h induced auditory brainstem response (ABR) threshold elevations, outer hair cell losses, and increase of Hes1 expression. Dexamethasone pretreatment prevented the NIHL with decreased Hes1 expression, which could be blocked by GR antagonist RU38,486.
XSLT template design for generating the web presentation layer (2004)

In Web-based information systems, separating business process logic from data and presentation logic creates a wide range of advantages. However, this separation is not easily achieved; even the data logic may be not separated from the presentation layer. Therefore it is necessary to define an abstract model for business processes, and then to map the model into a user's dynamic interface using the logic separating strategy. We present a stylesheet method for recognizing the process by extending the XSLT (Extensible Stylesheet Language Transformations) in order to achieve logic separation. This discussion provides an abstract specification of the business process and a scheme that extracts business model factors and their interactions using a Petri-net notation to show the business model from the process point of view. This is an attempt to separate the user interaction from the business process, that is, the separating of the dynamic components of the interaction Web document from the process structure of the Web applications. As a result, the development of service-oriented Web sites is made very easy and can be changed without affecting the other modules by virtue of the modularization concept. This facilitates development and maintenance of Web applications in independent manner.
An 11 GHz FPGA with test applications (2005)

FPGAs have been a popular topic among electrical engineers for over a decade. Modern FPGAs are denser, faster and use less power compared to PLD and CPLD. This paper presents a high speed FPGA that operates in the gigahertz range. An improved reconfigurable circuit is described. State-of-the-art IBM SiGe BiCMOS technology is used to realize this high speed FPGA. A measurement on a fabricated chip proves that this FPGA is capable of operating at 11 GHz, a SONET OC-192 standard, for optical applications.
Model-Assisted POD for Ultrasonic Detection of Cracks at Fastener Holes (2006)

To reduce the cost of conducting experimental probability of detection (POD) trials, methods which utilize models to account for factors that influence the inspection reliability are being developed. This paper reports the application of POD modeling to ultrasonic detection of cracks emanating from fastener holes. The differences between ultrasonic responses from EDM notches compared to fatigue cracks are examined, including the effects of natural variation in fatigue cracks and crack closure due to residual stresses.
A Hybrid Control Policy for Semi‐Active Vehicle Suspensions (2002)

Various control policies, such as skyhook and groundhook control, have often been considered for semi‐active vehicle suspensions. Past studies have shown the performance limitations of these policies, as well as others that have been considered for vehicle applications. This study will provide a look into an alternative control technique called "hybrid control", which attempts to merge the performance benefits of skyhook and groundhook control. The results of this study are based on an experimental evaluation of hybrid control using a quarter‐car rig and a magneto‐rheological damper. The control policy is employed and evaluated under a steady‐state or pure tone input, and a transient or step input. Peak‐to‐peak displacement and peak‐to‐peak acceleration are used to evaluate performance. The results indicate that hybrid control can offer benefits to both the sprung mass and the unsprung mass. The steady‐state results reveal that hybrid control can be used to reduce the peak‐to‐ peak displacements and accelerations of both bodies. The transient evaluation shows that hybrid control can be effective at reducing the peak‐to‐peak displacement of the sprung mass.
A theoretical study of resonant cavity-enhanced photodectectors with Ge and Si active regions (1992)

An integration of Ge or Si with compound semiconductors is considered for optical detectors at wavelengths ranging from the visible to 1.55 μm. Both Ge and Si are indirect band gap materials with relatively small absorption coefficients but very long carrier lifetimes. Using a resonant cavity formed by large band gap compound semiconductor mirrors surrounding Ge and Si active layers, high photosensitivity for thin (&lt;0.5 μm) absorbing layers can be achieved. Two different methods are discussed and compared for the calculation of the photosensitivity of resonant cavity enhanced detectors. The standing wave effect and its dependence on cavity parameters are analyzed. Design rules for such resonant cavity enhanced photodetectors are presented. The spectral response of some device designs to achieve high quantum efficiency and wavelength selectivity has also been theoretically investigated.
Near surface defects: Cause of deficit between internal and external open‐circuit voltage in solar cells (2021)

Abstract Interface recombination in a complex multilayered thin‐film solar structure causes a disparity between the internal open‐circuit voltage ( V OC,in ), measured by photoluminescence, and the external open‐circuit voltage ( V OC,ex ), that is, a V OC deficit. Aspirations to reach higher V OC,ex values require a comprehensive knowledge of the connection between V OC deficit and interface recombination. Here, a near‐surface defect model is developed for copper indium di‐selenide solar cells grown under Cu‐excess conditions. These cell show the typical signatures of interface recombination: a strong disparity between V OC,in and V OC,ex , and extrapolation of the temperature dependent q · V OC,ex to a value below the bandgap energy. Yet, these cells do not suffer from reduced interface bandgap or from Fermi‐level pinning. The model presented is based on experimental analysis of admittance and deep‐level transient spectroscopy, which show the signature of an acceptor defect. Numerical simulations using the near‐surface defects model show the signatures of interface recombination without the need for a reduced interface bandgap or Fermi‐level pinning. These findings demonstrate that the V OC,in measurements alone can be inconclusive and might conceal the information on interface recombination pathways, establishing the need for complementary techniques like temperature dependent current–voltage measurements to identify the cause of interface recombination in the devices.
Automating Efficient RAM-Model Secure Computation (2014)

RAM-model secure computation addresses the inherent limitations of circuit-model secure computation considered in almost all previous work. Here, we describe the first automated approach for RAM-model secure computation in the semi-honest model. We define an intermediate representation called SCVM and a corresponding type system suited for RAM-model secure computation. Leveraging compile-time optimizations, our approach achieves order-of-magnitude speedups compared to both circuit-model secure computation and the state-of-art RAM-model secure computation.
An optimal variable voltage scheduling (2003)

With the development of mobile and portable devices, there is a strong need for reducing the energy in integrated circuit chips. Dynamic voltage scaling (DVS) techniques reduce energy consumption by changing the operating speed and voltage in real-time, based on the workload of the operation. In this paper, we address the optimal variable voltage scheduling problem for different workloads to save the maximum energy. Both static DVS and real-time DVS methods are investigated.
1440 /spl times/ 1080 pixel, 30 frames per second motion-JPEG 2000 codec for HD-movie transmission (2005)

This paper describes techniques and approaches capable of achieving real-time motion-JPEG2000 encoding/decoding of high definition images with low power consumption. We propose a highly efficient VLSI implementation of procedure of two-dimensional wavelet transform that uses intermediate results through wavelet calculation. Double data-BUS and double encoder architecture with cross data flow is also introduced in order to make an improvement in coding performance and power consumption. The processor performs compression of 1440 /spl times/ 1080 pixels images with the speed of 30 frames per second (fps) at a required operating frequency as low as 54 MHz. A test chip of this implementation has been fabricated in a 0.18-/spl mu/m 5-layer CMOS process. The chip is 9.2 /spl times/ 9.2 mm/sup 2/ in size and consumes 0.9 W when supplied with 1.8 V and 54 MHz.
Expression of CCL17 and CCL22 by latent membrane protein 1‐positive tumor cells in age‐related Epstein–Barr virus‐associated B‐cell lymphoproliferative disorder (2008)

Age‐related Epstein–Barr virus‐positive (EBV + ) B‐cell lymphoproliferative disorder (ALPD) is a disease entity identified from a large‐scale re‐survey of cases diagnosed as diffuse large B‐cell lymphoma. ALPD is a group of EBV + polymorphic B‐cell lymphoma typically seen in elderly patients. An age‐associated decline in host immunity against EBV might be partly responsible for the pathogenesis of ALPD. Histologically, ALPD is often characterized by a minor proportion of EBV‐encoded RNA‐positive tumor cells in a background of extensive cellular infiltration, similar to that of classical Hodgkin's lymphoma. In contrast to Hodgkin and Reed–Sternberg cells, ALPD tumor cells are clearly positive for B cell markers CD20 and/or CD79a. Hodgkin and Reed–Sternberg cells produce various chemokines, including CCL17 and CCL22, that attract chemokine receptor CCR4‐expressing Th2 cells and regulatory T cells. Previously, we have shown that EBV‐immortalized B cells also produce CCL17 and CCL22 through latent membrane protein 1 (LMP1)‐mediated activation of nuclear factor κB. Here we examined expression of CCL17 and CCL22 in ALPD. ALPD tumor cells were often heterogeneous in size in accordance with the differential expression of EBV latent genes at the single cell level. LMP1‐expressing tumor cells were typically large in size and selectively positive for CCL17 and CCL22. CCR4 + cells and forkhead box protein 3 + regulatory T cells were abundantly present, and the majority of forkhead box protein 3 + cells were CCR4 + . Collectively, our data show production of CCL17 and CCL22 by LMP1 + large‐sized tumor cells and accumulation of CCR4‐expressing cells including regulatory T cells in ALPD. ( Cancer Sci 2008; 99: 296–302)
毛泽东与安娜·路易斯·斯特朗的三次会谈(节选) (1995)

安娜·路易斯·斯特朗是美国进步女作家和记者,中国人民的朋友,从1925年起她6次访华。1958年来中国定居,1970年3月在北京逝世。她多次与毛泽东主席会谈。本文节选了她建国后第二次1964年与毛泽东主席谈话的部分内容,以飨读者。
Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice (1998)

Charcot-Marie-Tooth disease type 1A is most commonly caused by a duplication of a 1.5 Mb region of chromosome 17 which includes the peripheral myelin protein 22 gene (PMP22). Over-expression of this gene leads to a hypomyelinating/demyelinating neuropathy and to severely reduced nerve conduction velocity. Previous mouse and rat models have had relatively high levels of expression of the mouse or human PMP22 gene leading to severe demyelination. Here we describe five lines of transgenic mice carrying increasing copies of the human PMP22 gene (one to seven) and expressing increasing levels of the transgene. From histological and electrophysiological observations there appears to be a threshold below which expression of PMP22 has virtually no effect; below a ratio of human/mouse mRNA expression of approximately 0.8, little effect is observed. Between a ratio of 0.8 and 1.5, histological and nerve conduction velocity abnormalities are observed, but there are no behavioural signs of neuropathy. An expression ratio >1.5 leads to a severe neuropathy. A second observation concerns the histology of the different lines; the level of expression does not affect the type of demyelination, but influences the severity of involvement.
ChemInform Abstract: Highly Enantioselective Hydrogenation of β‐Keto Esters under Mild Conditions. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Building Applications with iBeacon: Proximity and Location Services with Bluetooth Low Energy (2014)

High-precision location information is increasingly useful for mobile application developers, since it allows devices to interact with the world around them. This practical book shows you how to achieve arms reach accuracy with iBeacons, simple transmitters that enable your applications to react to nearby surroundings and then deliver timely, relevant informationespecially indoors, where GPS and cell service are inaccurate.Whether youre enabling a map, giving users directions, creating a game, recommending purchases, letting users check in, or creating an immersive experience, youll learn how iBeacons provide precise location information, empowering your applications to engage and interact with users nearby.Get examples of several application types you can build with iBeaconsLearn how iBeacons provide applications with proximity informationSet up, activate, and test iBeacons on both specialized and general-purpose hardwareExplore the APIs and tools you need to develop location-aware mobile applicationsUse built-in iOS features to interact with iBeacons, including PassbookBuild networks to help shoppers, travelers, conference attendees, and others find what theyre looking for
Supporting Collaborative Task Management in E-mail (2005)

-mail is one of the most successful computer applications ever developed. Despite its success, it is now dogged by numerous problems. Users complain about feeling overwhelmed by the volume of messages they receive, they have difficulties too in organizing and managing their e-mail data but, most importantly, they have problems in using e-mail to manage collaborative tasks (Bellotti, Ducheneaut, Howard, & Smith, 2003; Balter, 1998, 2000; Mackay, 1988; Whittaker, Jones, & Terveen, 2002a; Whittaker & Sidner, 1996). These require extended interaction with others for their definition and execution (Bellotti et al., 2003; Venolia, Gupta, Cadiz, & Dabbish, 2001; Whittaker & Sidner, 1996). As a result, users are often concurrently working on multiple outstanding tasks as they await responses from others concerning these tasks. This requires users to (a) create reminders, (b) identify messages that relate to the same task, and (c) combine information from these related messages. Currently, people try to use the email inbox to do this but our data indicate it is ineffective for these purposes. Other recent approaches attempt to tackle Collaborative Task Management but we show that these offer at best only partial solutions. In contrast, we present two systems, TeleNotes and ContactMap, that directly address Collaborative Task Management. These are motivated by empirical research into paper-based and people-based task management strategies. We describe how our systems implement these different strategies and present evaluation data for each system in use. We contrast the success of these two approaches with earlier work and discuss outstanding design and theory problems arising from our research.
Terahertz Sources Based on Intracavity Parametric Down-Conversion in Quasi-Phase-Matched Gallium Arsenide (2008)

We have efficiently generated tunable terahertz (THz) radiation using intracavity parametric down-conversion in gallium arsenide (GaAs). We used three types of microstructured GaAs to quasi-phase-match the interaction: optically contacted, orientation-patterned, and diffusion-bonded GaAs. The GaAs was placed in an optical parametric oscillator (OPO) cavity, and the THz wave was generated by difference-frequency mixing between the OPO signal and idler waves. The OPO used type-II phase-matched periodically poled lithium niobate as a gain medium and was synchronously pumped by a mode-locked laser at 1064 nm (7 ps and 200 nJ at 50 MHz). With center frequencies spanning 0.4-3.5 THz, 250-GHz bandwidth radiation was generated. We measured two orders of optical cascading generated by the mixing of optical and THz waves. In a doubly resonant oscillator (DRO) configuration, the efficiency increased by 21times over the singly resonant oscillator performance with an optical-to-THz efficiency of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-4</sup> and average THz power of 1 mW. The GaAs stabilized the DRO by a thermooptic feedback mechanism that created a quasi- continuous-wave train of THz pulses.
Differences in the Availability of<i>d</i>- and<i>l</i>-Enantiomers after Administration of Racemic Amphetamine to Rats (1978)

1. Rats were treated with racemic amphetamine or separately with the single enantiomers. The two optical isomers were determined in several brain areas, in plasma and urine. 2. The concentration of d-enantiomer significantly exceeds that of the l-enantiomer in brain and plasma but not in urine, following administration of racemic amphetamine. In contrast, when the two isomers are given separately, their brain concentrations are similar. 3. Such a difference does not appear in the brain of mice treated with racemic amphetamine or in the brain of rats pre-treated with SKF 525-A, an inhibitor of amphetamine hydroxylation. 4. The possibility that the l-isomer can interfere with hydroxylation of d-amphetamine is discussed.