gebhart/patrepeval huggingface dataset:
Fatigue Crack Propagation Behavior of Sn–Ag–Cu Solder Interconnects (2009)

Lead-free solders are replacing traditional lead-rich solders in the electronic industry. In the present study, the fatigue crack growth behavior of Sn-Ag-Cu solder interconnect has been investigated. An approach based on phase transformation theory and fracture mechanics was applied to predict fatigue crack propagation in a Sn-Ag-Cu interconnect, which consists of solder and intermetallic layers. Fatigue experiments were carried out on plastic ball grid array (PBGA) solder interconnects, different fatigue crack growth phases in interconnects were observed in the experiments. Displacement-controlled shear fatigue was done with a simple strain range from 0.01 to 0.1 (0.005 mum to 0.050 mum displacement) and cycle frequency of 0.1 Hz. It is found in the experiment that the majority of the interconnect lifetime is contained at the crack nucleation and early crack growth stage. Since solder alloys operate at high homologous temperatures, usually above 50% of their melting temperatures, combined creep and plasticity effects play important roles in interconnect failure and need to be considered in the analysis. A finite-element analysis was conducted to predict the required energy <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">U</i> to increase the crack by a unit area. Unified creep-plasticity theory was incorporated in the model to predict the creep and hysteresis effects on fatigue crack propagation in solder. The fatigue crack propagation rate in a Sn-Ag-Cu solder was predicted using phase transformation theory. Reasonable agreement between theoretical predictions and experimental results was obtained.
Experience with PACS in an ATM/Ethernet switched network environment (1998)

Legacy local area network (LAN) technologies based on shared media concepts are not adequate for the growth of a large-scale picture archiving and communication system (PACS) in a client-server architecture. First, an asymmetric network load, due to the requests of a large number of PACS clients for only a few main servers, should be compensated by communication links to the servers with a higher bandwidth compared to the clients. Secondly, as the number of PACS nodes increases, the network throughout should not measurably cut production. These requirements can easily be fulfilled using switching technologies. Here asynchronous transfer mode (ATM) is clearly one of the hottest topics in networking because the ATM architecture provides integrated support for a variety of communication services, and it supports virtual networking. On the other hand, most of the imaging modalities are not yet ready for integration into a native ATM network. For a lot of nodes already joining an Ethernet, a cost-effective and pragmatic way to benefit from the switching concept would be a combined ATM/Ethernet switching environment. This incorporates an incremental migration strategy with the immediate benefits of high-speed, high-capacity ATM (for servers and high-sophisticated display workstations), while preserving elements of the existing network technologies. In addition, Ethernet switching instead of shared media Ethernet improves the performance considerably. The LAN emulation (LANE) specification by the ATM forum defines mechanisms that allow ATM networks to coexist with legacy systems using any data networking protocol. This paper points out the suitability of this network architecture in accordance with an appropriate system design.
Conduction Mechanisms at Interface of AlN/SiN Dielectric Stacks with AlGaN/GaN Heterostructures for Normally-off High Electron Mobility Transistors: Correlating Device Behavior with Nanoscale Interfaces Properties (2017)

In this work, the conduction mechanisms at the interface of AlN/SiN dielectric stacks with AlGaN/GaN heterostructures have been studied combining different macroscopic and nanoscale characterizations on bare materials and devices. The AlN/SiN stacks grown on the recessed region of AlGaN/GaN heterostructures have been used as gate dielectric of hybrid metal-insulator-semiconductor high electron mobility transistors (MISHEMTs), showing a normally-off behavior (V<sub>th</sub> = +1.2 V), high channel mobility (204 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>), and very good switching behavior (I<sub>ON</sub>/I<sub>OFF</sub> current ratio of (5-6) × 10<sup>8</sup> and subthreshold swing of 90 mV/dec). However, the transistors were found to suffer from a positive shift of the threshold voltage during subsequent bias sweeps, which indicates electron trapping in the dielectric stack. To get a complete understanding of the conduction mechanisms and of the charge trapping phenomena in AlN/SiN films, nanoscale current and capacitance measurements by conductive atomic force microscopy (C-AFM) and scanning capacitance microscopy (SCM) have been compared with a macroscopic temperature-dependent characterization of gate current in MIS capacitors. The nanoscale electrical analyses showed the presence of a spatially uniform distribution of electrons trapping states in the insulator and the occurrence of a density of 7 × 10<sup>8</sup> cm<sup>-2</sup> of local and isolated current spots at high bias values. These nanoscale conductive paths can be associated with electrically active defects responsible for the trap-assisted current transport mechanism through the dielectric, observed by the temperature-dependent characterization of the gate current. The results of this study can be relevant for future applications of AlN/SiN bilayers in GaN hybrid MISHEMT technology.
Long Double-Stranded RNA-Mediated RNA Interference and Immunostimulation: Long Interfering Double-Stranded RNA as a Potent Anticancer Therapeutics (2011)

In most applications, small interfering RNAs are designed to execute specific gene silencing via RNA interference (RNAi) without triggering nonspecific responses such as immunostimulation. However, in anticancer therapeutics, immunostimulation combined with specific oncogene silencing could be beneficial, resulting in the synergistic inhibition of cancer cell growth. In this study, we report an immunostimulatory long double-stranded RNA (dsRNA) structure with the ability to trigger RNAi-mediated specific target gene silencing, termed as long interfering dsRNA (liRNA). liRNA targeting Survivin mRNA not only efficiently and specifically triggered target gene silencing via RNAi, but also stimulated the protein kinase R pathway to induce the expression of interferon β. As a result, the ability of Survivin-targeting liRNA to inhibit cancer cell growth was superior over conventional small interfering RNA or nontargeting dsRNA structures. Our results thus provide a simple yet efficient dual function immunostimulatory RNAi-triggering structure, which is potentially applicable for the development of anticancer therapeutics.
Glibenclamide-sensitive mechanism is involved in helodermin-produced vasodilatation in rat mesenteric artery. (1997)

Helodermin-caused vascular relaxation was simultaneously measured with intracellular Ca2+ concentration ([Ca2+]i) in rat mesenteric artery. Helodermin caused concentration-dependent relaxation in the mesenteric artery preconstricted with norepinephrine (NE). Helodermin-caused relaxation was accompanied by decrease in [Ca2+]i, D-cis-Diltiazem, a Ca2+ channel blocker, also lowered the [Ca2+]i and tension increased by NE. However, helodermin relaxed the artery more efficiently than D-cis-diltiazem, suggesting that the peptide decreased myofilament Ca2+ sensitivity. The vascular relaxation and the corresponding decrease in [Ca2+]i induced by helodermin were partly, but significantly attenuated by glibenclamide. Helodermin-induced vascular responses were mimicked by vasoactive intestinal polypeptide (VIP) or forskolin. Furthermore, helodermin increased cAMP contents in the mesenteric artery. These findings show that vasodilatation induced by helodermin is attributable to lowered [Ca2+]i of arterial smooth muscle partly through the activation of glibenclamide-sensitive K+ channels, and to decrease in the myofilament Ca2+ sensitivity. The increase in the cellular cAMP content probably plays a key role in the peptide-induced vasorelaxation.
T-DLA: An Open-source Deep Learning Accelerator for Ternarized DNN Models on Embedded FPGA (2019)

Deep Neural Networks (DNNs) have become promising solutions for data analysis especially for raw data processing from sensors. However, using DNN-based approaches can easily introduce huge demands of computation and memory consumption, which may not be feasible for direct deployment onto the Internet of Thing (IoT) devices, since they have strict constraints on hardware resources, power budgets, response latency, and manufacturing cost. To bring DNNs into IoT devices, embedded FPGA can be one of the most suitable candidates by providing better energy efficiency than GPU and CPU based solutions, and higher flexibility than ASICs. In this paper, we propose a systematic solution to deploy DNNs on embedded FPGAs, which includes a ternarized hardware Deep Learning Accelerator (T-DLA), and a framework for ternary neural network (TNN) training. T-DLA is a highly optimized hardware unit in FPGA specializing in accelerating the TNNs, while the proposed framework can significantly compress the DNN parameters down to two bits with little accuracy drop. Results show that our training framework can compress the DNN up to 14.14x while maintaining nearly the same accuracy compared to the floating point version. By illustrating our proposed design techniques, the T-DLA can deliver up to 0.4TOPS with 2.576W power consumption, showing 873.6x and 5.1x higher energy efficiency (fps/W) on ImageNet with Resnet-18 model comparing to Xeon E5-2630 CPU and Nvidia 1080 Ti GPU. To the best of our knowledge, this is the first instruction-based highly efficient ternary DLA design reported from the literature.
Nonlinear filtering applied to single-view backpropagated images of strong scatterers (1996)

In weak scattering diffraction tomography, there is a well-known Fourier relationship between the field scattered by an unknown object and the scattering potential that characterizes the object. For these weakly scattering objects, those that satisfy the Born or Rytov approximation, the scattered field generated from a sequence of different illumination directions complements Fourier data on the unknown scattering potential. A low-pass reconstruction is found by Fourier inversion. A simulation is presented in which the scattered far field from several strongly scattering penetrable two-dimensional cylinders is backpropagated into the object domain. For these more strongly scattering objects, a single wavelength and a single illumination direction are used to provide limited Fourier data on the product of the scattering potential and the total field. A nonlinear filtering technique, known as differential cepstral filtering, is used to isolate the scattering potential and to suppress artifacts introduced by the perturbing field component. Reconstructed images calculated by this technique from exact scattered-field data from cylindrically symmetric objects are shown.
B7 Costimulatory Requirements of T Cells at an Inflammatory Site (1998)

The requirement for T cell costimulation at sites of infection and inflammation is unresolved. Herpes stromal keratitis (HSK) is a CD4+ T cell-regulated inflammatory response to herpes simplex virus type 1 infection of the cornea. Our findings suggest that susceptibility to HSK is determined by the microenvironment of the infected cornea. The cornea is normally devoid of Langerhans cells (LC), but these APC are present in the surrounding conjunctiva, and migrate into the cornea following infection. The costimulatory molecule B7-2 was constitutively expressed on LC in conjunctiva, but B7-1 was not detectable until 3 days postinfection. LC were the only cells in the cornea that expressed B7-1 through 7 days postinfection. B7-1 was expressed on some, but not all, migrating LC, suggesting that LC migration and B7-1 expression can be independently regulated. The early LC migration and B7-1 expression was independent of T cells, but T cells were required for the massive accumulation of B7-1+ LC in the cornea at the onset of inflammation. Local inhibition of B7-1 function within the infected cornea prevented HSK. Locally blocking B7-2 function did not reduce HSK incidence, but markedly reduce HSK severity. This is the first direct demonstration that naturally expressed B7 is required within an inflammatory site.
The mammalian centrosome and its functional significance (2008)

Primarily known for its role as major microtubule organizing center, the centrosome is increasingly being recognized for its functional significance in key cell cycle regulating events. We are now at the beginning of understanding the centrosome's functional complexities and its major impact on directing complex interactions and signal transduction cascades important for cell cycle regulation. The centrosome orchestrates entry into mitosis, anaphase onset, cytokinesis, G1/S transition, and monitors DNA damage. Recently, the centrosome has also been recognized as major docking station where regulatory complexes accumulate including kinases and phosphatases as well as numerous other cell cycle regulators that utilize the centrosome as platform to coordinate multiple cell cycle-specific functions. Vesicles that are translocated along microtubules to and away from centrosomes may also carry enzymes or substrates that use centrosomes as main docking station. The centrosome's role in various diseases has been recognized and a wealth of data has been accumulated linking dysfunctional centrosomes to cancer, Alstrom syndrome, various neurological disorders, and others. Centrosome abnormalities and dysfunctions have been associated with several types of infertility. The present review highlights the centrosome's significant roles in cell cycle events in somatic and reproductive cells and discusses centrosome abnormalities and implications in disease.
Characterization of cellulose aldehyde using Fourier transform infrared spectroscopy (2001)

Abstract Fourier transform infrared spectroscopy has been used to study cellulose aldehyde groups in bleached cotton, unbleached cotton, and in periodate oxidized cotton. Second derivative spectroscopy could reproducibly identify aldehyde bonds in oxidized cotton only if the samples were predried at 110°C for 24 h; the aldehyde band appeared at 1732–1734 cm −1 . Diffuse reflectance spectroscopy in the Environmental Chamber readily detected the above aldehyde absorbances at temperatures above 100°C. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 82: 1195–1202, 2001
The Effect of Alternate Defrost Strategies on the Reverse-Cycle Defrost of an Air-Source Heat Pump (1988)

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to digital@library.tamu.edu, referencing the URI of the item.
Complete Genome Sequence of <i>Pseudomonas denitrificans</i> ATCC 13867 (2013)

Pseudomonas denitrificans ATCC 13867, a Gram-negative facultative anaerobic bacterium, is known to produce vitamin B12 under aerobic conditions. This paper reports the annotated whole-genome sequence of the circular chromosome of this organism.
De Novo Sequencing and Disulfide Mapping of a Bromotryptophan-Containing Conotoxin by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2006)

T-1-family conotoxins belong to the T-superfamily and are composed of 10-17 amino acids. They share a common cysteine framework and disulfide connectivity and exhibit unusual posttranslational modifications, such as tryptophan bromination, glutamic acid carboxylation, and threonine glycosylation. We have isolated and characterized a novel peptide, Mo1274, containing 11 amino acids, that shows the same cysteine pattern, -CC-CC, and disulfide linkage as those of the T-1-family members. The complete sequence, GNWCCSARVCC, in which W denotes bromotryptophan, was derived from MS-based de novo sequencing. The FT-ICR MS/MS techniques of electron capture dissociation (ECD), infrared multiphoton dissociation, and collision-induced dissociation served to detect and localize the tryptophan bromination. The bromine contributes a distinctive isotopic distribution in all fragments that contain bromotryptophan. ECD fragmentation results in the loss of bromine and return to the normal isotopic distribution. Disulfide connectivity of Mo1274, between cysteine pairs 1-3 and 2-4, was determined by mass spectrometry in combination with chemical derivatization employing tris(2-carboxyethyl)phosphine, followed by differential alkylation with N-ethylmaleimide and iodoacetamide. The ECD spectra of the native and partially modified peptide reveal a loss of bromine in a process that requires the presence of a disulfide bond.
High SN ratio and signal-stability in triple layer perpendicular media (1997)

SNR and signal-stability in CoCr Ta/CoZrNb/CoSm triple-layer perpendicular media have been studied. Low medium noise was obtained by (1) uniformity of the magnetic direction in the CoZrNb layer exchange coupled with the CoSm layer (2) optimal saturation magnetization and thickness of the CoCrTa perpendicular layer. Recorded signals were stable under the conditions of RT·15hours and 60°C·5hs. Stray field didn't cause any decay of signals for the medium with a 600nm-thick CoZrNb layer.
Aviation and the Global Atmosphere (1999)

This report presents a comprehensive review and assessment of the global effects of aviation on the global atmosphere. All gases and particulates emitted by aircraft and the role they play in modifying chemical properties in the atmosphere are examined. Also examined are how potential changes in aircraft technology, transport operations and the institutional, regulatory and economic framework of the airline industry might alter emissions in the future.
Mechanical Properties, Microstructure and Durability of Portland Cement-Based Systems Containing Micro-Reinforcement (1994)

Peer reviewed: Yes
Citrulline: pharmacological perspectives and its role as an emerging biomarker in future (2012)

L-Citrulline is a naturally occurring non-essential amino acid, an intermediate in urea cycle and conditionally essential in intestinal pathology. It is a potent hydroxyl radical scavenger and much more effective precursor of arginine and nitric oxide (NO) than arginine itself so exploited in therapeutics. Plasma citrulline concentration is used by clinicians to assess functional enterocyte mass in various chronic and acute small bowel pathologies like short bowel syndrome that has become an indication in clinical practice. Its supplementation is likely to be used in conditions like erectile dysfunction, sickle cell anemia, short bowel syndrome (to restore nitrogen balance), hyperlipidemia, cancer chemotherapy, hypercholestremia, in hyperoxic lung damage, urea cycle disorders, Alzheimers disease, multi-infarct dementia and as an immunomodulator. Its emerging role as a biomarker in intestinal pathology and early diagnosis of Rheumatoid arthritis has spread considerable interest. Antibody detection to Anti-cyclic citrullinated peptide (ACCP) antibodies can be recommended for early detection of RA decreasing joint damage and deformity, because these are detected well before the onset of disease manifestations of RA. The test is highly specific than RF (Rheumatoid factor), with moderate sensitivity, but much useful in differentiating RA from other disorders. Further studies and exploration is required in these areas.
Effect of Energy‐Reduced Diets High in Dairy Products and Fiber on Weight Loss in Obese Adults (2005)

We found no evidence that diets higher than 800 mg of calcium in dairy products or higher in fiber and lower in glycemic index enhance weight reduction beyond what is seen with calorie restriction alone.
The use of antidepressant drugs in dermatology (2001)

This paper provides an updated review of the use of antidepressant drugs in dermatology. Some of the psychiatric disorders that are usually comorbid with dermatological disorders and respond to antidepressants include major depressive disorder, obsessive compulsive disorder, body dysmorphic disorder, social phobia and post-traumatic stress disorder usually secondary to trauma and abuse during early life. Cutaneous symptoms may be the feature of a primary psychiatric disorder, e.g. cutaneous body image problems, dermatitis artefacta, neurotic excoriations and trichotillomania, or psychiatric syndromes may be comorbid with a primary dermatological disorder such as the association of major depressive disorder or social phobia with psoriasis and obsessive compulsive disorder with acne excoriee. Some of the salient pharmacological properties of the tricyclic antidepressants (TCAs) and the selective serotonin reuptake inhibitor (SSRI) antidepressants are reviewed. The review indicates that the SSRI antidepressants are potentially beneficial in the management of all the major psychiatric syndromes that are encountered in dermatological disorders. The generally more favourable side-effect profile of the SSRIs, such as lower cardiotoxicity in contrast to the TCAs, has made them the first-line agents for the treatment of depression. Furthermore, some of the pharmacological properties of the antidepressant agents that are not related to their antidepressant activity, such as the histamine H1 blocking effect of TCAs, such as doxepin, amitriptyline and trimipramine, are of benefit in dermatological conditions such as urticaria and pruritus. This paper reviews the general guidelines for use of antidepressants and salient drug-drug interactions resulting mainly from the inhibition of the cytochrome P450 (CYP) 2D6 and 3A3/4 isoenzymes by some of the SSRI antidepressants. Before prescribing an antidepressant agent, the specific guidelines, side-effect profile, drug-drug interactions and most current indications should always be obtained.
Brequinar sodium. (1996)

The future use of BQR as a component of a treatment regimen for preventing graft rejection is uncertain. The drug exhibits a number of characteristics that are considered desirable for inclusion in a multidrug antirejection protocol. BQR is an effective immunosuppressive agent and can act as a single agent to prevent the rejection of allografts and xenografts. Its immunosuppressive activity is especially useful in those situations for which inhibition of antibody production is an important objective of the treatment protocol. The activity of BQR is substantially improved by including the drug with other immunosuppressive agents, such as CsA, that differ in the mechanisms by which they prevent immune responses. This type of combination therapy provides for effective and safe immunosuppression in rodent models. Additional desirable characteristics include the high level of bioavailability, patient acceptance, and ease of monitoring plasma drug levels. The primary difficulties associated with the application of BQR therapy to humans is the narrow ratio of the level of drug therapy necessary to provide for effective prevention of graft rejection and the appearance of side effects that limit the use of the drug. The principal feature of BQR's pharmacologic activity that appears to be responsible for this narrow therapeutic window may be the extended plasma half-life of the drug. The most effective treatment schedule for preventing graft rejection in rodents is administration of the drug on alternate days. Treating with smaller doses more frequently does not improve graft survival, suggesting that reducing the plasma half-life may allow for more frequent peaks of drug activity without increasing the severity of the side effects. The phase I trials of BQR have been completed and the extension of these studies for a more careful examination of the efficacy of the drug may depend upon biochemical modification of the parent drug.