gebhart/patrepeval huggingface dataset:
Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProbing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptidesDonald J. Kyle, Jennifer A. Martin, Ronald M. Burch, John P. Carter, Songfeng Lu, Sonya Meeker, Judith C. Prosser, James P. Sullivan, James Togo, and Cite this: J. Med. Chem. 1991, 34, 8, 2649–2653Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/jm00112a047https://doi.org/10.1021/jm00112a047research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Calculation and Measurement of Helmholtz Coil Fields (1994)

Abstract : Helmholtz coils are used to develop uniform magnetic fields for a variety of research applications. Helmholtz coils can be easily constructed, and the fields easily calculated. This makes them especially useful in calibrating sensors and numerous other low frequency magnetic field testing applications. This particular report will discuss the calculation and measurement of Helmholtz coil fields to be used for testing of composite materials to low frequency magnetic fields. Testing, Helmholtz coils, Composite, Magnetic field
The Interactive Marketplace (2000)

Most e-commerce experts agree that click-and-buy shopping cart sites are fast becoming a thing of the past. Soon, the only e-businesses that will matter will be those which allow customers to custom design the products they buy. At Ford, the Ford-Oracle AutoExchange site transformed Ford's supply chain from one based on forecasts and building for inventory to a real-time, build-to-order model. In this practical guide to the future of e-business. BuildNet, Inc. Chairman Keith T. Brown clearly explains why the most successful business-to-consumer e-businesses, now and in the years ahead, are those built on interactive business-to-business platforms that integrate Internet technology into all phases of business operations. And he arms readers with the knowledge and skills needed to create solid interactive business plans.
Compact binary logic circuits design using negative differential resistance devices (2006)

A novel logic design style for negative differential resistance (NDR) device based MOBILE circuits is introduced. Enjoying a reduced number of NDR devices, it eases circuit design, brings essential power savings, and should improve circuit manufacturability.
Crystal defects observed by the etch-pit method and their effects on Schottky-barrier-diode characteristics on $(\bar{2}01)$ β-Ga<sub>2</sub>O<sub>3</sub> (2017)

A pixel array of vertical Schottky-barrier diodes (SBDs) was fabricated and measured on the surface of a β-Ga2O3 single crystal. Subsequently, etch pits and patterns were observed on the same surface. Three types of etch pits were discovered: (1) a line-shaped etch pattern originating from a void and extending toward the [010] direction, (2) an arrow-shaped etch pit whose arrow's head faces toward the [102] direction and, (3) a gourd-shaped etch pit whose point head faces toward the [102] direction. Their average densities were estimated to be 5 × 102, 7 × 104, and 9 × 104 cm−2, respectively. We confirmed no clear relationship between the leakage current in SBDs and these crystalline defects. Such results are obtained because threading dislocations run mainly in the [010] growth direction and do not go through the sample plate.
Iridium(I) and Iridium(III) Complexes Supported by a Diphenolate Imidazolyl-Carbene Ligand (2009)

Deprotonation of 1,3-di(2-hydroxy-5-tert-butylphenyl)imidazolium chloride (1a) followed by reaction with chloro-1,5-cyclooctadiene Ir(I) dimer affords the anionic Ir(I) complex [K][{OCO}Ir(cod)] (2: OCO = 1,3-di(2-hydroxy-5-tert-butylphenyl)imidazolyl; cod = 1,5-cyclooctadiene), the first Ir complex stabilized by a diphenolate imidazolyl-carbene ligand. In the solid state 2 exhibits square-planar geometry, with only one of the phenoxides bound to the metal center. Oxidation of 2 with 2 equiv of [FeCp2][PF6] generates the Ir(III) complex [{OCO}Ir(cod)(MeCN)][PF6] (3). Reaction of 3 with H2 results in the liberation of cyclooctane and a species capable of catalyzing the hydrogenation of cyclohexene to cyclohexane. Displacement of cyclooctadiene from 3 can be achieved by heating in acetonitrile to form [{OCO}Ir(MeCN)3][PF6] (4) or by reaction with either PMe3 or PCy3 to generate [{OCO}Ir(PMe3)3][PF6] (5) or [{OCO}Ir(PCy3)2(MeCN)][PF6] (6), respectively. 6 reacts with CO in acetonitrile to give an equilibrium mixture of 6 and [{OCO}Ir(PCy3)2(CO)][PF6] (7) and with chloride to generate [{OCO}Ir(PCy3)2Cl] (8). The solid-state structure of 8 shows that the diphenolate imidazolyl-carbene ligand is distorted from planarity; DFT calculations suggest this is due to an antibonding interaction between the phenolates and the metal center in the highest occupied molecular orbital (HOMO) of the complex. 8 undergoes two successive reversible one-electron oxidations in CH2Cl2 at −0.22 and at 0.58 V (vs ferrocene/ferrocenium); EPR spectra, mass spectroscopy, and DFT calculations suggest that the product of the first oxidation is [{OCO}Ir(PCy3)2Cl]+ (8+), with the unpaired electron occupying a molecular orbital that is delocalized over both the metal center and the diphenolate imidazolyl-carbene ligand.
Lasers incorporating 2D photonic bandgap mirrors (1996)

Semiconductor lasers incorporating a 2D photonic lattice as a one end mirror in a Fabry-Perot cavity are demonstrated. The photonic lattice is a 2D hexagonal close-packed array with a lattice constant of 220 nm. Pulsed threshold currents of 110 mA were observed from a 180 µm laser.
Do different conditioning regimens really make a difference? (2012)

Abstract Over the past 15 years, the use of reduced-intensity/nonmyeloablative conditioning regimens before allogeneic hematopoietic stem cell transplantation has been increasing. Despite major disparities in the level of myeloablation, intensity of immunosuppression (including great diversity of in vivo T-cell depletion), and postgraft immunomodulation, the different approaches have contributed jointly to a modification of the stage of allogeneic stem cell transplantation: transplantation-related procedure mortality has been decreased dramatically, allowing allogeneic immunotherapy to be used in previously excluded populations, including elderly patients, young but clinically unsuitable patients, patients with lymphoid malignancies or solid tumors, and patients without an HLA-identical related or unrelated donor. Together, these diverse regimens have provided one of the biggest breakthroughs since the birth of allogeneic BM transplantation. However, consensus on how to reach the optimal goal of minimal transplantation-related mortality with maximum graft-versus-tumor effect is far from being reached, and further studies are needed to define optimal conditioning and immunomodulatory regimens that can be integrated to reach this goal. These developments, which will most likely vary according to different clinical situations, have to be compared continuously with advances achieved in traditional allogeneic transplantation and nontransplantation treatments. However, the lack of prospective comparative trials is and will continue to make this task challenging.
Detection of anomalies from user profiles generated from system logs (2011)

We describe research into the identification of anomalous events and event patterns as manifested in computer system logs. Prototype software has been developed with a capability that identifies anomalous events based on usage patterns or user profiles, and alerts administrators when such events are identified. To reduce the number of false positive alerts we have investigated the use of different user profile training techniques and introduce the use of abstractions to group together applications which are related. Our results suggest that the number of false alerts that are generated is significantly reduced when a growing time window is used for user profile training and when abstraction into groups of applications is used.
Image segmentation by region integration using initial dependence of the K-means algorithm (1998)

An image needs to be segmented before object-based coding can be performed. This paper proposes a practical method of doing this by region integration. Clustering based on the K-means algorithm is widely used, but this tends to segment the image into too many small regions. Further, since the shape of initial clusters has a lasting influence, region segmentation sometimes takes place in areas other than the original contour of an object in the image. To overcome these problems, we propose a three-step region integration based on the K-means algorithm. We applied this new method to several different natural images. The results show that we can extract the contours of regions from different images even with the same parameters, and even after varying the number of initial clusters. © 1998 Scripta Technica, Syst Comp Jpn, 29(14): 68–80, 1998
Studies on the Monoamine Oxidase (MAO)-Catalyzed Oxidation of Phenyl-Substituted 1-Methyl-4-phenoxy-1,2,3,6-tetrahydropyridine Derivatives: Factors Contributing to MAO-A and MAO-B Selectivity (1995)

The structural parameters responsible for the substrate and inhibitor selectivities of the monoamine oxidases (MAO) A and B remain poorly understood. This situation has improved somewhat with structure-activity studies that have been performed on nuclear-substituted pargyline derivatives and 4-substituted 1-methyl-1,2,3,6-tetrahydropyridine derivatives. The results of these studies suggest that the active site of MAO-A is sterically more accommodating than the active site of MAO-B. In the present work we have undertaken a more systematic structure-substrate activity analysis with the aid of a series of 4-phenoxytetrahydropyridine analogs substituted at the para, meta, and ortho positions of the phenyl ring with chloro, methoxy, methyl, nitro, and phenyl groups. All of the compounds proved to be good substrates for both MAO-A and MAO-B, and all were better MAO-A substrates than MAO-B substrates. The best defined structural parameter relating to selectivity again was the relatively better MAO-A substrate properties of tetrahydropyridine derivatives bearing bulky C-4 substituents. Attempts to identify stereoelectronic effects related to substrate properties and selectivity with this series of compounds were not successful. Although some structural correlates with substrate activity can be made, overall the present state of knowledge is inadequate to provide good descriptors of structural features that characterize MAO-A and MAO-B substrates.
Preparation and Characterization of Novel Hybrid Materials Formed from (Ti,Sn)O<sub>2</sub> Nanoparticles and Polyaniline (2003)

This paper describes the synthesis and characterization of new organic/inorganic hybrid materials formed from the mixed oxide (Ti,Sn)O2 nanoparticles and polyaniline (PANI). The preparation method is based on a sol−gel technique using titanium tetra-isopropoxide and tin tetrachloride as oxide precursors, and two synthetic routes to the hybrids formation were employed, based on the addition of aniline after or before the sol formation. Different amounts of aniline were used to verify this effect on the characteristics of the formed materials. Samples were characterized by thermal analysis, X-ray diffractometry, Raman, UV−vis, and FT-IR spectroscopy, transmission electron microscopy, cyclic voltammetry, and conductivity measurements. Results show that the different experimental routes are successful in producing hybrids formed by oxide nanoparticles or nanotubes and polyaniline in its conducting form, the emeraldine salt. There is little difference between the samples obtained by the two synthetic routes employed, except by the amount of polymer in the final material. The hybrids that contain approximately 10% weight of polyaniline are formed as a core/shell mixed oxide/polyaniline material.
Virus in Water (1971)

A preliminary study was carried out on evaluating a flow-through gauze sampler for its efficiency in recovering virus from both fresh and seawater. An attenuated type 1 poliovirus was used as the working model. When tap water was sampled, the amounts of virus adsorbed by the gauze pads were very small, about 2% of the total number of virus particles flowing through the device. The virus adsorption and recovery increased to 15 to 19% when seawater was sampled. Addition of NaCl to tap water produced a much better effect on virus adsorption and recovery by this device, i.e., 47% of the total virus particles in each sample. The best viral elution from the pads was obtained by using buffer solution of pH 8.0 to 9.0 containing a small amount of animal serum. Repeated elutions from the pads were necessary to recover the most virus although the first eluate contained approximately 50% of the adsorbed virus. Further development of this device appears warranted, because of (i) the simplicity of the procedure, (ii) its capability of sampling large volume of water, (iii) the low cost of collecting samples, and (iv) the feasibility of obtaining a rough quantitative assessment of viral pollutants in water examined.
ChemInform Abstract: Synthesis and Evaluation of the Catalytic Properties of Homo‐ and Hetero‐Bimetallic Complexes Containing Bridging Diphenylphosphido Ligands. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Assessment of coronary flow reserve with fast cine phase contrast magnetic resonance imaging: Comparison with measurement by Doppler guide wire (1999)

Fast cine phase contrast magnetic resonance imaging (fast cine phase contrast MRI) can measure phasic coronary flow velocity in humans.The purpose of this study was to compare the coronary flow velocity reserves measured by MR IMAGING with those obtained by Doppler guide wire.Nineteen patients with ischemic or valvular heart disease were studied.Fast cine phase contrast MR images of the left anterior descending (LAD) artery were acquired during breath-hold time in the basal state and after administration of dipyridamole.Flow velocity in the LAD artery was also measured with Doppler guide wire before and after venous injection of dipyridamole in all subjects.Flow velocity in the coronary artery measured with MR IMAG-ING in the basal state (12.5 ؎ 4.9 cm/sec) was significantly lower than that obtained with Doppler guide wire (32.4 ؎ 12.1 cm/sec, P F 0.01).However, MR assessments of coronary flow velocity reserve showed a good linear correlation with those measured by Doppler guide wire (r ‫؍‬ 0.91).In conclusion, fast cine phase contrast MR imaging is a useful technique, which can provide a noninvasive assessment of flow reserve ratios in patients with coronary artery disease.
Computational and synthetic approaches for the discovery of HIV-1 integrase inhibitors (2006)

In recent years our research group has been engaged in the structure-function study of IN enzyme and in the development of new HIV-1 IN-inhibitors. We first developed threedimensional hypothetical pharmacophore models for the binding of IN inhibitors to the enzyme. In particular we focused our attention on -diketo acid (DKA) derivatives which represent the major leads in the development of anti-HIV-1 IN drugs, considering that the only two IN inhibitors undergoing clinical trials belong to this family.
Wireless device identification using oscillator control voltage as RF fingerprint (2017)

Device identification has been considered as a main trend to maintain security in wireless communications. Specific characteristics of different components of transmitters have been recently exploited as their RF fingerprints. In this paper, a new method is presented to uniquely identify a transmitter using a phase locking mechanism. In the proposed method, a Phase-Locked Loop is used to lock on the transmitter to observe the control voltage of the oscillator. The steady state value of the control voltage is used as fingerprint to identify a transmitter.
The archival history of the Cinque Ports (1965)

(1965). The archival history of the Cinque Ports. Journal of the Society of Archivists: Vol. 3, No. 1, pp. 15-19.
MPEG-4 based stereoscopic video sequences encoder (2004)

In this paper, we propose an object-based MPEG-4 compatible stereoscopic video sequence encoder. We aim at efficient stereoscopic video compression for videoconferencing and 3D telepresence systems. The stereoscopic video sequence includes one main view and one auxiliary view. The main view is encoded using an MPEG-4 encoder and the auxiliary view is encoded by joint motion and disparity compensation. After the input sequences are balanced to compensate for lighting conditions and camera differences, the joint disparity and motion regularization is performed on a VOP basis. The output of the encoder contains two bitstreams, a main bitstream, which can be decoded by a standard MPEG-4 decoder, and an auxiliary bitstream. Simulation results show that the joint estimation and regularization of disparity and motion fields provide more accurate vector fields and efficient compression for the auxiliary stream. The proposed system achieves high image quality at lower bitrate than existing stereoscopic video encoders.
Enhanced Authentication Mechanism Using Multilevel Security Model (2009)

This paper presents a proposed multilevel authentication method which is implemented especially in sensitive applications where they contain multilevel secure and confidential data. The proposed method divides the system into multiple sensitive levels and tests users against different authentication methods for each level. Most levels are subdivided further into secure sublevels. Each sublevel contains its own privileges and data types which are managed by an Identity Manager (IM) whose responsibility is to transit users to other higher sublevels. The transition's decision is done by assigning different weights to each authentication method .After a series of tests, the IM must generate a status report describing the results and the decision made to each user's activity. This technique permits granting only the required privileges for a selected group of users and limits the configuration functions of those that users in a particular user group can perform.
Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells (1997)

This manuscript reviews the low-dose survival work using the DMIPS cell analyser that has been carried out at the Gray Laboratory in the U.K. and the British Columbia Cancer Research Centre in Canada. It describes low dose hyper-radiosensitivity (HRS) detected after single doses of X-rays less than approximately 0.3 Gy and the subsequent increased radioresistant response (IRR) seen as the dose increases up to 1 Gy. Work is summarized from studies in V79 cells, normal human and human tumour cell lines and mutant cell lines deficient in DNA repair. The data are considered in light of the hypothesis that hyper-radiosensitivity and increased radioresistance reflect the existence of an inducible protective mechanism, possibly triggered by DNA damage.
Novel Red Electroluminescent Polymers Derived from Carbazole and 3,6-Bis(2-thienyl)-1,2,7-benzothiadiazole (2002)

A series of novel carbazole-based soluble copolymers of different composition was synthesized by Suzuki coupling reaction. Efficient energy transfer from the wide-band-gap segment polycarbazole due to exciton trapping on narrow-band-gap benzothiadiazole sites has been observed. Maximum electroluminescence wavelengths of the copolymers varied between 668 nm and 716 nm, and the external quantum efficiency for copolymer devices is 0.3% for copolymers with 20% benzothiadiazole content.
Isolation and Structure Elucidation of New Taxoids from Taxus brevifolia (1994)

An investigation of Taxus brevifolia extracts afforded two taxoids characterized by the A-nortaxol ring system. These were identified as 7,13-dideacetyl-9,10- debenzoyltaxchinin C [1] and 9-deacetyl-9-benzoyl-10-debenzoylbrevifoliol [4]. Structures were elucidated by spectroscopic methods, and in particular by comparison of nmr data with those of taxchinin C and brevifoliol.
The Human Immunodeficiency Virus Type 1 Ribosomal Frameshifting Site Is an Invariant Sequence Determinant and an Important Target for Antiviral Therapy (2004)

Human immunodeficiency virus type 1 (HIV-1) utilizes a distinctive form of gene regulation as part of its life cycle, termed programmed -1 ribosomal frameshifting, to produce the required ratio of the Gag and Gag-Pol polyproteins. We carried out a sequence comparison of 1,000 HIV-1 sequences at the slippery site (UUUUUUA) and found that the site is invariant, which is somewhat surprising for a virus known for its variability. This prompted us to prepare a series of mutations to examine their effect upon frameshifting and viral infectivity. Among the series of mutations were changes of the HIV-1 slippery site to those effectively utilized by other viruses, because such mutations would be anticipated to have a relatively mild effect upon frameshifting. The results demonstrate that any change to the slippery site reduced frameshifting levels and also dramatically inhibited infectivity. Because ribosomal frameshifting is essential for HIV-1 replication and it is surprisingly resistant to mutation, modulation of HIV-1 frameshifting efficiency potentially represents an important target for the development of novel antiviral therapeutics.
Memory channel network for PCI (1996)

A memory-based networking approach provides clusters of computers up to 1,000 times the communication performance of conventional networks, with no compromise in cost or reliability. The memory channel for PCI's performance gains are the result of a system design approach that exploits natural cluster constraints to define a memory-based network. MC implements a form of virtual shared memory that permits applications to completely bypass the operating system and perform cluster communication directly from the user level. The hardware's simple and powerful communication model supports error handling at almost no cost or complexity to the application; guaranteed ordering under errors is the key innovation. The end result: Real-world cluster communication latency dropped by up to two orders of magnitude, and overhead by up to three orders of magnitude. These improvements elevate a lowly set of standard PCI computers running Unix into an impressive, highly available, parallel computing system.