gebhart/patrepeval huggingface dataset:
Ultrasound Measurement of the Fibrous Cap in Symptomatic and Asymptomatic Atheromatous Carotid Plaques (2005)

FCT measurement of carotid atheroma with ultrasound is feasible. Discrimination of symptomatic from asymptomatic plaques with mean FCT values is good. Prospective studies should determine whether this ultrasound marker is reliable.
beta(3)-Integrin cytoplasmic binding proteins. (2004)

Integrins are cell-surface adhesion receptors that play an important role in mediating numerous physiological processes,including inflammation, migration, adhesion, and proliferation. Integrin regulation by events within the cell has been termed "inside-out " signaling; this is a capacity that is unique to integrin receptors. As is typical of other cell-surface receptors, integrins can also transduce signals from outside the cell into the cytoplasm on binding extracellular ligands ("outside-in signaling "). Integrins are composed of an alpha and a beta subunit, which form a heterodimer. The beta(3)-integrin family consists of alpha(IIb)beta(3)-found on platelets and megakaryocytes, and the more widely distributed alpha(v)beta(3). beta Subunits consist of a large extracellular domain, a single transmembrane segment, and a relatively short cytoplasmic tail. The cytoplasmic domains do not contain intrinsic tyrosine kinase activity, and therefore signaling occurs primarily via recruitment of intracellular signaling molecules. Integrins form transmembrane connections, and the interactions between integrin cytoplasmic domains, intracellular factors (cytoplasmic proteins and intracellular signaling pathways), and membrane-anchored proteins play an important role in integrin-mediated events. There are at least 21 proteins that associate with integrin beta tails to regulate cell motility, proliferation, differentiation, and apoptosis. In this review, we will focus on 10 of these proteins and their function in integrin-mediated events.
Incorporation and Exclusion of Long Chain Alkyl Halides in Fatty Acid Monolayers at the Air−Water Interface (2010)

Mixed monolayers of deuterated palmitic acid C(15)D(31)COOH (dPA) and deuterated stearic acid C(17)D(35)COOH (dSA) with 1-bromoalkanes of different alkyl chain length (C(4) to C(16)) at the air-water interface were investigated. Alkanes and 1-chlorohexadecane ClC(16)H(33) (ClHex) were also studied to compare the effects of the halogen on the mixed monolayers. Surface pressure-area isotherms and Brewster angle microscopy (BAM) were used to obtain the organization and phase behavior, providing a macroscopic view of the mixed monolayers. A molecular-level understanding of the interfacial molecular organization and intermolecular interactions was obtained by using vibrational sum frequency generation (SFG) spectroscopy and infrared reflection-absorption spectroscopy (IRRAS). It was found that from the alkyl halide molecules investigated 1-bromopentadecane, BrC(15)H(31) (BrPent), 1-bromohexadecane, BrC(16)H(33) (BrHex), and ClHex incorporate into the fatty acid monolayers. Alkanes of 15- and 16-carbon chain length do not incorporate into the fatty acid monolayer, which suggests that the halogen is needed for incorporation. Isotherms and spectra suggest that BrHex molecules are squeezed out, or excluded, from the fatty acid monolayer as the surface pressure is increased, while BAM images confirm this. Additionally, SFG spectra reveal that the alkyl chains of both fatty acids (dPA and dSA) retain an all-trans conformation after the incorporation of alkyl halide molecules. BAM images show that at low surface pressures BrHex does not affect the two-dimensional morphology of the dPA and dSA domains and that BrHex is miscible with dPA and dSA. We also present for the first time BAM images of BrHex deposited on a water surface, which reveal the formation of aggregates while the surface pressure remains unchanged from that of neat water.
Inspection focus: A SEF to success (2011)

Sarah Neville gives some guidance on completing your self-evaluation form and explains why doing so can be a stepping stone towards obtaining that coveted ‘outstanding’.
Improved neuron MOS-transistor structures for integrated neural network circuits (2001)

The neuron MOS transistor is a recently discovered device which is capable of executing a weighted sum calculation of multiple input signals and threshold operation based on the result of summation, thereby simulating the function of biological neurons. A comprehensive set of neuron test transistors has been designed, where a number of input gates are coupled capacitively to a floating gate, which controls the channel current. Integrated circuits for neural network applications have also been designed, based on the neuron MOS transistors. These circuits include neuron CMOS inverters and A/D and D/A converters. To increase the accuracy of the neuron MOSFET structures, calibration techniques are proposed and tested. All the test structures and circuits are implemented by using a standard 0.8 µm double-polysilicon CMOS technology. Attention was paid to saving of the layout area and reducing power consumption.
Liposomes and Blood Cells: A Flow Cytometric Study (2003)

To clarify the interactions of liposomes with blood cells, this study examined the behaviour of liposomes of a range of compositions in the presence of purified human blood cells in buffer or plasma; or in whole blood, or in mice in vivo. Liposomes, labeled with the hydrophilic fluorochrome, carboxy fluorescein (CF), or with membrane-sequestering R18 or FITC-labeled phospholipids, were mixed with blood cells and the appearance of the fluorochromes in the blood cell population was monitored by flow cytometry. Irrespective of composition, with or without poly(ethylene glycol), all types of liposomes were found to interact rapidly and dose-dependently with red cells, leukocytes and platelets, both in vitro and in vivo. This took place equally in the presence and the absence of plasma proteins and functional enzyme cascades, suggesting that the prime facie interaction is opsonization-independent and is consistent with liposome-blood cell fusion.
Collagen synthesis in atherosclerosis: too much and not enough (1999)

Fibrillar collagen is a critical component of atherosclerotic lesions. Uncontrolled collagen accumulation leads to arterial stenosis, while excessive collagen breakdown combined with inadequate synthesis weakens plaques thereby making them prone to rupture. This review discusses cellular sources of collagen synthesis in atherosclerosis, local and systemic factors modulating collagen gene expression, as well as temporal and spatial patterns of collagen production in human and experimental atherosclerotic lesions.
Optical plankton analyser: A flow cytometer for plankton analysis, II: Specifications (1989)

An analysing flow cytometer, the optical plankton analyser (OPA), is presented. The instrument is designed for phytoplankton analysis, having a sensitivity comparable with commercially available flow cytometers, but a significantly extended particle size range. Particles of 500 microns in width and over 1,000 microns in length can be analysed. Sample flow rates of up to 55 microliters/s can be used. Also, the dynamic range of the instrument is significantly increased for particles larger than about 5 microns. The optics, hydraulics, and electronics of the instrument are described, including the best form for a low fluid shear cuvette. The new pulse quantification technique we call digital integration is presented. This technique is essential for the instrument to handle both short and very long particles with a large dynamic range. Test measurements demonstrating particle size range and dynamic range are presented. Dynamic ranges of 10,000 and 100,000 were typically observed, measuring field samples with Microcystis aeruginosa colonies, whereas one sample showed a dynamic range of 10(6). A simple method for interpretation of time of flight (TOF) data in terms of particle morphology is presented. The specifications of the instrument are given.
A doctor's cash book: The economy of general practice in the 1830s (1983)

from Edinburgh) who identified themselves as a new and distinct group, quite separate from the physicians and the "pure" surgeons who practised surgery only.
Biological foundation for periodontitis as a potential risk factor for atherosclerosis (2004)

An emerging concept suggests that a pathogenic burden from different sources might overcome an individual threshold culminating in clinical sequela. P. gingivalis contributes directly and indirectly to atherosclerosis.
Divergence of Quaternary Structures Among Bacterial Flagellar Filaments (2008)

It has been widely assumed that the atomic structure of the flagellar filament from Salmonella typhimurium serves as a model for all bacterial flagellar filaments given the sequence conservation in the coiled-coil regions responsible for polymerization. On the basis of electron microscopic images, we show that the flagellar filaments from Campylobacter jejuni have seven protofilaments rather than the 11 in S. typhimurium. The vertebrate Toll-like receptor 5 (TLR5) recognizes a region of bacterial flagellin that is involved in subunit-subunit assembly in Salmonella and many other pathogenic bacteria, and this short region has diverged in Campylobacter and related bacteria, such as Helicobacter pylori, which are not recognized by TLR5. The driving force in the change of quaternary structure between Salmonella and Campylobacter may have been the evasion of TLR5.
Effect of Resonator Axis Skew on Normal Incidence Impedance (2003)

High by-pass turbofan engines have fewer fan blades and lower rotation speeds than their predecessors. Consequently, the noise suppression at the low frequency end of the noise spectra has become an increasing concern. This has led to a renewed emphasis on improving noise suppression efficiency of passive, duct liner treatments at the lower frequencies. For a variety of reasons, passive liners are comprised of locally-reacting, resonant absorbers. One reason for this design choice is to satisfy operational and economic requirements. The simplest liner design consists of a single layer of honeycomb core sandwiched between a porous facesheet and an impervious backing plate. These resonant absorbing structures are integrated into the nacelle wall and are very ef- ficient over a limited bandwidth centered on their resonance frequency. Increased noise suppression bandwidth and greater suppression at lower frequencies is typically achieved for conventional liners by increasing the liner depth and incorporating thin porous septa into the honeycomb core. However, constraints on liner depth in modern high by-pass engine nacelles severely limit the suppression bandwidth extension to lower frequencies. Also, current honeycomb core liners may not be suitable for irregular geometric volumes heretofore not considered. It is of interest, therefore, to find ways to circumvent liner depth restrictions and resonator cavity shape constraints. One way to increase effective liner depth is to skew the honeycomb core axis relative to the porous facesheet surface. Other possibilities are to alter resonator cavity shape, e.g. high aspect ratio, narrow channels that possibly include right angle bends, 180. channel fold-backs, and splayed channel walls to conform to irregular geometric constraints. These possibilities constitute the practical motivation for expanding impedance modeling capability to include unconventional resonator orientations and shapes. The work reported in this paper is in the nature of a progress report and is limited to examining the implications of resonator axis skew on the composite normal incidence impedance of an array of resonator channels. Specifically, experimental results are compared with a modified impedance prediction model for highaspect- ratio, rectangular, resonator channels with varying amounts of skew relative to the incident particle velocity. It is shown that for resonator channel widths of 1 to 2 mm, aspect ratios of 25 to 50, and skew angles of zero to sixty degrees, the surface impedance of test models can be predicted with good accuracy. Predicted resistances and reactances are particularly well correlated through the first resonance and first anti-resonance for all six test models investigated. Beyond the first anti-resonance, the impedance prediction model loses the ability to predict details of resistance and reactance but still predicts the mean trends very well.
Proper tail recursion and space efficiency (1998)

The IEEE/ANSI standard for Scheme requires implementations to be properly tail recursive . This ensures that portable code can rely upon the space efficiency of continuation-passing style and other idioms. On its face, proper tail recursion concerns the efficiency of procedure calls that occur within a tail context. When examined closely, proper tail recursion also depends upon the fact that garbage collection can be asymptotically more space-efficient than Algol-like stack allocation.Proper tail recursion is not the same as ad hoc tail call optimization in stack-based languages. Proper tail recursion often precludes stack allocation of variables, but yields a well-defined asymptotic space complexity that can be relied upon by portable programs.This paper offers a formal and implementation-independent definition of proper tail recursion for Scheme. It also shows how an entire family of reference implementations can be used to characterize related safe-for-space properties, and proves the asymptotic inequalities that hold between them.
Comparison of SVM and neural network classifiers in automatic detection of clustered microcalcifications in digitized mammograms (2008)

This paper presents a computer-aided diagnosis (CAD) system for automatic detection of clustered microcalcifications (MCs) in digitized mammograms. The proposed system consists of two main steps. First, potential microcalcification pixels in the mammograms are segmented out by using 4 mixed features consisting of two wavelet features and two gray level statistical features and then the potential microcalcification pixels are labeled into potential individual microcalcification objects by their spatial connectivity. Second, MCs are detected by using a set of 17 features extracted from the potential individual microcalcification objects. The classifier which is used in the first step is a multilayer feedforward neural network (NN) classifier but for the second step we have used three different classifier which are multilayer feedforward neural network (NN), SVM with polynomial kernel and SVM with Gaussian RBF kernel and the result of each classifier is obtained separately. The method is applied to a database of 40 mammograms (Nijmegen database) containing 105 clusters of MCs. A free-response operating characteristics (FROC) curve is used to evaluate the performance of CAD system with each classifier. Results show that the proposed system gives quite satisfactory detection performance. In particular, 89.55% mean true positive detection rate is achieved at the cost of 0.782, 1 and 0.95 false positive per image for neural network, support vector machine (SVM) with polynomial kernel and SVM with Gaussian RBF kernel classifiers, respectively.
PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity (2004)

Pst1p was previously identified as a protein secreted by yeast regenerating protoplasts, which suggests a role in cell wall construction. ECM33 encodes a protein homologous to Pst1p, and both of them display typical features of GPI-anchored proteins and a characteristic receptor L-domain. Pst1p and Ecm33p are both localized to the cell surface, Pst1p being at the cell membrane and possibly also in the periplasmic space. Here, the characterization of pst1Delta, ecm33Delta and pst1Delta ecm33Delta mutants is described. Deletion of ECM33 leads to a weakened cell wall, and this defect is further aggravated by simultaneous deletion of PST1. As a result, the ecm33Delta mutant displays increased levels of activated Slt2p, the MAP kinase of the cell integrity pathway, and relies on a functional Slt2-mediated cell integrity pathway to ensure viability. Analyses of model glycosylated proteins show glycosylation defects in the ecm33Delta mutant. Ecm33p is also important for proper cell wall ultrastructure organization and, furthermore, for the correct assembly of the mannoprotein outer layer of the cell wall. Pst1p seems to act in the compensatory mechanism activated upon cell wall damage and, in these conditions, may partially substitute for Ecm33p.
Effect of forphenicinol on the production of lipopolysaccharide-induced interferon and tumor necrosis factor and on the growth of Meth A fibrosarcoma in mice. (1987)

Oral administration of forphenicinol stimulated the production of lipopolysaccharide (LPS)-induced interferon (IFN) in mice up to 21-fold over control when given more than 10 days before the elicitation. The IFN production in mice sensitized with bacillus Calmette-Guerin (BCG) 14 days before LPS injection was further augmented by forphenicinol given after BCG. In addition to the IFN production, forphenicinol increased production of LPS-induced tumor necrosis factor (TNF) in mice sensitized with BCG, and the dose of LPS required to induce TNF was reduced by the drug. Furthermore, forphenicinol augmented the antitumor effect of BCG and LPS on Meth A fibrosarcoma.
ELECTRIC PROPERTIES OF BORIDES OF RARE-EARTH METALS (1959)

The electric and thermoelectric properties of borides of several rare earth metals were investigated. It is shown that in the region from room temperature to 700 to 800 deg C the materials are metallic conductors with hole conductivity. Methods were developed to obtain pseudobinary alloys of hexaborides with high electric resistance and small work-function of electrons. (auth)
Laboratory and Field Evaluation of the Role of Drill Solids in Formation Damage and Reduced Horizontal Well Productivity (1996)

Abstract This paper examines the role of drill solids in causing formation and completion damage in horizontal openhole completions. Drill solids are routinely kept to a minimum in drilling fluids, mainly to improve drilling properties. However, these drill solids, even at low concentrations, represent a significant source of insoluble particulates that become incorporated in the drill-in fluid filtercake. Not only is the potential for formation damage greater, but these filtercakes laden with insoluble drill solids can be deposited on screens resulting in reduced productivity through screen plugging. The objective of this paper is to illustrate the effect of drill solids contained in drill-in fluids on formation damage and well screen plugging and to emphasize the importance of minimizing solids, not only to maintain the desired drill fluid rheology, but also to effect better filtercake cleanup. New laboratory test methods have been used to study formation damage in a 2-foot long horizontal wellbore model incorporating dynamic filtercake deposition on natural and synthetic core material. The model measures formation damage in radial flow. Formation damage tests with drill solids were performed for both water based and synthetic based drill-in fluids. Testing was also performed to simulate prepacked screen damage using a variety of commercially available drill-in fluids and common resin-coated gravel sizes. Results of these tests with laboratory-prepared fluids have been compared against the performance of field fluids and will eventually be correlated with field well performance. Background The use of horizontal wells to maximize recovery of oil and gas has become commonplace. However, operators frequently find horizontal wells do not provide the expected productivity after completion. While cased hole completions exploit perforation techniques to bypass the zone of formation damage caused by drilling, the openhole completions commonly used in horizontal wells do not provide a means of bypassing this damage. Previous work has discussed formation damage caused by drill-in fluids. Often, these studies have concluded that formation damage is caused by solids invasion into the rock or from damage caused by incompatible fluid filtrate. Some investigators have presented evidence that DIF filtercakes did not penetrate into rock matrices. Fraser's study showed ESEM photo images of different types of DIF filtercakes tightly compacted onto formation rock surfaces. He found very little filtercake invasion in the rock matrix. Burnham and Browne have discussed the concept of "lift off" pressure that can be used characterize the behavior of DIF filtercake on formation rock. Their studies suggest that "formation damage" can be caused by too "tight" a filtercake on rock surface. P. 749
The Body in the Mind (1987)

There are books-few and far between-which carefully, delightfully, and genuinely turn your head inside out. This is one of them. It ranges over some central issues in Western philosophy and begins the long overdue job of giving us a radically new account of meaning, rationality, and objectivity.-Yaakov Garb, San Francisco Chronicle
Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation (2001)

NaF, a potent G protein activator and Ser/Thr phosphatase inhibitor, significantly increased albumin permeability and decreased transcellular electrical resistance (TER), indicating endothelial cell (EC) barrier impairment. EC barrier dysfunction induced by NaF was accompanied by the development of actin stress fibers, intercellular gap formation, and significant time-dependent increases in myosin light chain (MLC) phosphorylation. However, despite rapid, albeit transient, activation of Ca(2+)/calmodulin-dependent MLC kinase (MLCK), the specific MLCK inhibitor ML-7 failed to affect NaF-induced MLC phosphorylation, actin cytoskeletal rearrangement, and reductions in TER, suggesting a limited role of MLCK in NaF-induced EC activation. In contrast, strategies to reduce Rho (C3 exoenzyme or toxin B) or to inhibit Rho-associated kinase (Y-27632 or dominant/negative RhoK) dramatically reduced MLC phosphorylation and actin stress fiber formation and significantly attenuated NaF-induced EC barrier dysfunction. Consistent with this role for RhoK activity, NaF selectively inhibited myosin-specific phosphatase activity, whereas the total Ser/Thr phosphatase activity remained unchanged. These data strongly suggest that MLC phosphorylation, mediated primarily by RhoK, and not MLCK, participates in NaF-induced EC actin cytoskeletal changes and barrier dysfunction.