gebhart/patrepeval huggingface dataset:
Towards an operational SAR monitoring system for monitoring environmental flows in the Macquarie Marshes (2014)

Multi-frequency synthetic aperture radar (SAR) data was acquired over the Macquarie Marshes Nature Reserve in north central New South Wales (NSW), Australia, to demonstrate the potential of imaging radar for mapping and monitoring wetland extent and inundation patterns in an inland, semi-arid wetland environment. A sequence of ALOS PALSAR and TerraSAR-X images acquired between January 2007 and April 2008 captured the wetlands in three successive phases: dry, wet and transitional. Visual observation of multi-temporal and multi-frequency SAR backscatter data confirmed the capacity of SAR to respond to changes in surface water, soil moisture and biomass. Longer wavelength L-band SAR provides a tool for discriminating wetlands, mapping surface water and detecting below-canopy inundation. Shorter wavelength X-band SAR provides a tool for detecting flushes in growth of vegetation in response to higher soil moisture from flooding. PALSAR data demonstrated a high capacity for discrimination of different wetland classes, while TerraSAR-X data was less suited to discriminating between cover types. The integration of X- and L-band data revealed the extent of floodplain inundation and presence of aquatic vegetation in ponded areas. Given a stable, well-calibrated time-series of SAR data, change analysis provides a mechanism for understanding the hydrological and/or ecological change in an area. In the longer term, it is envisioned that radar will provide a valuable tool within an operational system for monitoring the impact of environmental flows in NSW inland wetlands.
Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III (2017)

Abstract Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene ( CLRN1 ). Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf by P21-P25. Early onset profound hearing loss in KO mice and lack of information about the cochlear cell type that requires Clrn1 expression pose challenges to therapeutic investigation. We generated KO mice harboring a transgene, TgAC1, consisting of Clrn1 -UTR ( Clrn1 cDNA including its 5′ and 3′ UTR) under the control of regulatory elements ( Atoh1 3′ enhancer/β-globin basal promoter) to direct expression of Clrn1 in hair cells during development and down regulate it postnatally. The KO-TgAC1 mice displayed delayed onset progressive hearing loss associated with deterioration of the hair bundle structure, leading to the hypothesis that hair cell expression of Clrn1 is essential for postnatal preservation of hair cell structure and hearing. Consistent with that hypothesis, perinatal transfection of hair cells in KO-TgAC1 mice with a single injection of AAV- Clrn1 -UTR vector showed correlative preservation of the hair bundle structure and hearing through adult life. Further, the efficacy of AAV- Clrn1 vector was significantly attenuated, revealing the potential importance of UTR in gene therapy.
The application of magnetic bead hybridization for the recovery and STR amplification of degraded and inhibited forensic DNA (2011)

A common problem in the analysis of forensic DNA evidence is the presence of environmentally degraded and inhibited DNA. Such samples produce a variety of interpretational problems such as allele imbalance, allele dropout and sequence specific inhibition. In an attempt to develop methods to enhance the recovery of this type of evidence, magnetic bead hybridization has been applied to extract and preconcentrate DNA sequences containing short tandem repeat (STR) alleles of interest. In this work, genomic DNA was fragmented by heating, and sequences associated with STR alleles were selectively hybridized to allele-specific biotinylated probes. Each particular biotinylated probe-DNA complex was bound to streptavidin-coated magnetic beads using enabling enrichment of target DNA sequences. Experiments conducted using degraded DNA samples, as well as samples containing a large concentration of inhibitory substances, showed good specificity and recovery of missing alleles. Based on the favorable results obtained with these specific probes, this method should prove useful as a tool to improve the recovery of alleles from degraded and inhibited DNA samples.
[Screening of differential expression genes of human skin epidermal stem cells at different development stages by cDNA microarray technique]. (2011)

Gene expression profiles of epidermal stem cells cultured in vitro, harvested from fetuses, children, and adult, exhibit obvious difference. This may be closely related to different stages of proliferation and differentiation of human epidermal stem cell and self-repair ability of wound at different developmental stages.
Low-Temperature Confocal Microscopy on Individual Molecules near a Surface (1997)

The spectral behavior of single terrylene molecules at a hexadecane−silica interface structure is studied. Different sample preparation techniques indicate that molecules close to a silica substrate in a hexadecane matrix are subject to additional dephasing or spectral diffusion. The temperature activation of the homogeneous line width of these molecules shows much reduced activation energies as compared to those of molecules in bulk hexadecane. These low-lying activation energies may be attributed to surface phonon states or local phonon modes particular to the interface structure. With the aid of a low-temperature scanning confocal microscope, the distance of single terrylene molecules to the silica surface can be measured with a precision of 60 nm. A drastic increase of the homogeneous line width for molecules with distances less than 150 nm to the silica surface is found.
Traffic flow fundamentals (1989)

Overall, we demonstrate that co-administration of soluble fibres viz. gum acacia, inulin and L. casei NCDC19 fermented milk exhibited the anti-adiposity effects, improved insulin sensitivity and dyslipidemia in mice via modulation of lipid mobilization genes.
Olefin Polymerization by Dinuclear Zirconium Catalysts Based on Rigid Teraryl Frameworks: Effects on Tacticity and Copolymerization Behavior (2017)

Toward gaining insight into the behavior of bimetallic catalysts for olefin polymerization, a series of structurally related binuclear zirconium catalysts with bisamine bisphenolate and pyridine bisphenolate ligands connected by rigid teraryl units were synthesized. Anthracene-9,10-diyl and 2,3,5,6-tetramethylbenzene-1,4-diyl were employed as linkers. Bulky SiiPr3 and SiPh3 substituents were used in the position ortho to the phenolate oxygen. Pseudo-Cs and C2 symmetric isomers are observed for the binuclear complexes of bisamine bisphenolate ligands. In general, binuclear catalysts show higher isotacticity compared to the monozirconium analogues, with some differences between isomers. Amine bisphenolate-supported dizirconium complexes were found to be moderately active (up to 1.5 kg mmolZr–1 h–1) for the polymerization of 1-hexene to isotactically enriched poly-1-hexene (up to 45% mmmm) in the presence of stoichiometric trityl or anilinium borate activators. Moderate activity was observed for the production of isotactically enriched polypropylene (up to 2.8 kg mmolZr–1 h–1 and up to 25.4% mmmm). The previously proposed model for tacticity control based on distal steric effects from the second metal site is consistent with the observed behavior. Both bisamine bisphenolate and pyridine bisphenolate supported complexes are active for the production of polyethylene in the presence of MAO with activities in the range of 1.1–1.6 kg mmolZr–1 h–1 and copolymerize ethylene with α-olefins. Little difference in the level of α-olefin incorporation is observed between mono- and dinuclear catalysts supported with the pyridine bisphenolate catalysts. In contrast, the size of the olefin affects the level of incorporation differently between monometallic and bimetallic catalysts for the bisamine bisphenolate system. The ratio of the incorporation levels with dinuclear vs mononuclear catalysts decreases with increasing comonomer size. This effect is attributed to steric pressure provided by the distal metal center on the larger olefin in dinuclear catalysts.
Minimal architecture zinc–bromine battery for low cost electrochemical energy storage (2016)

A minimal-architecture zinc–bromine battery that eliminates expensive balance-of-plant components is demonstrated with stable performance and low cost.
Analytically and accurately determined quasi-static parameters of coupled microstrip lines (1996)

Using modified conformal mapping technique and magnetic-wall approximation, closed-form expressions for quasi-static parameters of coupled microstrip lines are determined accurately in this paper. They are found to be very accurate when compared with the well-recognized numerical solutions in the literature. Specifically, the present effective permittivities for both modes are accurate to within 0.4%, the even-mode characteristic impedance is accurate to within 1.2%, and the odd-mode impedance is accurate to within 1.8% for w/h/spl ges/0.4 and 3.8% for 0.4>w/h/spl ges/0.1. They are believed to be the most accurate closed-form formulas for coupled microstrip lines and should find applications in microstrip computer-aided design. In addition, two sets of existing equations have been checked against exact values or accurate results. According to the comparisons, they are either unacceptable or partially acceptable. Three data tables instead of figures are given for clarity.
LPP source system development for HVM (2009)

Laser produced plasma (LPP) systems have been developed as a viable approach for the EUV scanner light source for optical imaging of circuit features at sub-32nm and beyond nodes on the ITRS roadmap. This paper provides a review of development progress and productization status for LPP extreme-ultra-violet (EUV) sources with performance goals targeted to meet specific requirements from leading scanner manufacturers. We present the latest results on power generation, stable and efficient collection, and clean transmission of EUV light through the intermediate focus. We report on measurements taken using a 5sr collector optic on a production system. Power transmitted to intermediate focus (IF) is shown. The lifetime of the collector mirror is a critical parameter in the development of extreme ultraviolet LPP lithography sources. Deposition of target material as well as sputtering of the multilayer coating or implantation of incident particles can reduce the reflectivity of the mirror coating during exposure. Debris mitigation techniques are used to inhibit damage from occuring, the results of these techniques are shown. We also report on the fabrication of 5sr collectors and MLM coating reflectivity, and on Sn droplet generators with droplet size down to 30μm diameter.
Detecting field cancerization using a hyperspectral imaging system (2013)

The hyperspectral imaging system offers a new, non-invasive method for early detection of field cancerization. Lasers Surg. Med. 45:410-417, 2013. © 2013 Wiley Periodicals, Inc.
Methylenetetrahydrofolate reductase (MTHFR): The incidence of mutations C677T and A1298C in the Ashkenazi Jewish population (1999)

The polymorphic mutation C677T in the gene of MTHFR is considered a risk mutation for spina bifida and vascular disease. Another common mutation on the MTHFR gene, A1298C, has also been described as another risk mutation. We studied the frequencies of these two mutations on DNA samples from healthy Jewish individuals and compared them to the frequency of these mutations in DNA samples obtained from healthy individuals in South Texas. The presence of the C677T allele was determined by PCR and Hinf I digestion, and mutation A1298C by PCR and Mbo II digestion. A total of 310 alleles was examined for C677T in the Ashkenazi samples and 400 alleles in the non-Jewish samples. The rate of C677T among the Ashkenazi Jewish alleles was 47.7% as compared to 28.7% among the alleles from the non-Jewish population. The difference is statistically significant, P < 0.0005. Mutation A1298C was examined in 298 alleles of Jewish individuals and 374 alleles of non-Jewish counterparts from Texas. The rate of the A1298C mutation in the Jewish samples was 27.2% whereas in the non-Jewish was 35%. This was also statistically significant, P < 0.031. No individuals were homozygous for both mutations or were found to be homozygous for one mutation with heterozygosity of the other mutation, and that the C677T and the A1298C alleles did not occur in cis position. This study shows a unique distribution of C677T and the A1298C alleles among the Ashkenazi Jews. In spite of high frequency of C677T mutation, spina bifida is less common among Ashkenazi Jews. Further studies are needed to establish whether the C677T and the A1298C mutations have an impact on vascular disease in the Ashkenazi Jewish population.
Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells. (1994)

Mineralocorticoids have been suggested to act on blood vessels, leading to increased vasoreactivity and peripheral resistance. However, the site of their production has so far been believed to be only the adrenal cortex. Here, we show direct evidence that vascular cells per se are aldosteronogenic, possessing their own system that responds to the steroid. Using polymerase chain reaction after reverse transcription, the CYP11B2 mRNA encoding the key enzyme for the biosynthesis of aldosterone was detected in both endothelial cells and smooth muscle cells cultivated from human pulmonary artery. The aldosterone receptor (type 1 mineralocorticoid receptor) gene was also found to be expressed in smooth muscle cells and, to a lesser extent, in endothelial cells. CYP11B2 gene expression in smooth muscle cells was stimulated by angiotensin II, the effector peptide of the renin-angiotensin system. Furthermore, the angiotensin II-induced increase in [3H]leucine incorporation in smooth muscle cells was significantly enhanced by aldosterone but inhibited by ZK 91587, a type 1 mineralocorticoid receptor antagonist. This may indicate that vascular aldosterone participates in the angiotensin II-induced hypertrophy of vascular smooth muscle cells. The present study therefore provides the starting point for a novel understanding of the molecular basis of vascular remodeling and hypertension.
[Scintigraphy with 99mTc-HMPAO-marked leukocytes and abdominal tumors: clinical interpretation of scintigraphy results]. (2000)

The 99mTc-HMAPAO-labelled leucocyte scan is a widely employed diagnostic tool in the assessment of inflammatory and infective diseases. Nevertheless, leucocytes accumulation in neoplastic lesions has been reported. In the present study, aimed at the exploration of the abdomen and performed on 62 patients, positive scintigraphic findings were obtained in 66.6% (4/6) of the neoplasms and in 6.45% (4/62) of the studied cases. These scintigraphic results, even if they have to be considered as false positive cases, effectively reflect histopathologic changes present in the neoplastic tissue. On the basis of the obtained results, leucocytes accumulation in abdominal malignancies is probably due to the presence of necrosis and ulceration and to the resulting infection of the tumour.
Self‐Healing Polymers: Self‐Healing Polymer Coatings (Adv. Mater. 6/2009) (2009)

Dramatic reduction in corrosion of a steel plate coated with a self-healing coating (right) as compared to a conventional coating is demonstrated. Two samples were scratched and placed in 5% NaCl for 5 days. The background is an optical image (2× magnification), in the foreground is an SEM image of the scratch. In the self-healing sample, the scratch has almost completely self-healed, while in the control sample, the scratch remains all the way down to the substrate, as reported by Paul Braun and co-workers on p.645.
Automatic Detection of Malignant Melanoma using Macroscopic Images (2014)

In order to distinguish between benign and malignant types of pigmented skin lesions, computerized procedures have been developed for images taken by different equipment that the most available one of them is conventional digital cameras. In this research, a new procedure to detect malignant melanoma from benign pigmented lesions using macroscopic images is presented. The images are taken by conventional digital cameras with spatial resolution higher than one megapixel and by considering no constraints and special conditions during imaging. In the proposed procedure, new methods to weaken the effect of nonuniform illumination, correction of the effect of thick hairs and large glows on the lesion and also, a new threshold-based segmentation algorithm are presented. 187 features representing asymmetry, border irregularity, color variation, diameter and texture are extracted from the lesion area and after reducing the number of features using principal component analysis (PCA), lesions are determined as malignant or benign using support vector machine classifier. According to the dermatologist diagnosis, the proposed processing methods have the ability to detect lesions area with high accuracy. The evaluation measures of classification have indicated that 13 features extracted by PCA method lead to better results than all of the extracted features. These results led to an accuracy of 82.2%, sensitivity of 77% and specificity of 86.93%. The proposed method may help dermatologists to detect the malignant lesions in the primary stages due to the minimum constraints during imaging, the ease of usage by the public and nonexperts, and high accuracy in detection of the lesion type.
Clinical and Biochemical Findings in Progressive Familial Intrahepatic Cholestasis (1994)

The clinical findings in 33 patients with progressive familial intrahepatic cholestasis (PFIC) are presented. Symptoms developed almost invariably before 6 months of age with severe pruritus and moderate jaundice. Other clinical findings included wheezing and nosebleeds, fat-soluble vitamin deficiency states, and cholelithiasis. Lower values for gamma-glutamyl transpeptidase, averaging 15 IU/L before the administration of phenobarbital, and cholesterol, which averaged 156 mg/dl, are helpful in distinguishing PFIC from other pediatric cholestatic liver diseases. Autosomal recessive inheritance is probable. Twenty-six patients are alive at 12.9 +/- 6.7 years of age, all having had successful surgical treatment, either partial biliary diversion (n = 17) or orthotopic liver transplantation (n = 10). Seven patients died at a mean age of 3.9 +/- 2.4 years, as a result of liver failure in two, hepatocellular carcinoma in two, and complications of liver transplantation in three.
A dose-dependent relationship between mercury exposure from dental amalgams and urinary mercury levels: a further assessment of the Casa Pia Children’s Dental Amalgam Trial (2011)

Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings. Our study was designed to determine whether there was a significant dose-dependent correlation between increasing Hg exposure from dental amalgams and urinary Hg levels. Hg exposure depends on the size and number of teeth with dental amalgams. Overall, consistent with the results observed in the parent study, there was a statistically significant dose-dependent correlation between cumulative exposure to Hg from dental amalgams and urinary Hg levels, after covariate adjustment. Further, it was observed that urinary Hg levels increased by 18% to 52% among 8 to 18 year old individuals, respectively, with an average exposure to amalgams, in comparison to study subjects with no exposure to amalgams. The results of our study suggest that dental amalgams contribute to ongoing Hg exposure in a dose-dependent fashion.
Formation of body-centered-cubic tantalum via sputtering on low-κ dielectrics at low temperatures (2006)

Sputtered Ta films (60 nm) were deposited at room temperature onto selected substrates, including silicon, SiO2, porous methyl silsesquioxane (porous MSQ), parylene-N (Pa-N) caulked porous MSQ, benzocyclobutene (BCB), and SiLK layers. It was observed that the Ta structure after deposition mainly depends on the underlayer surface chemistry. β-Ta with a resistivity of ∼130–160μΩcm and an average grain size of ∼20nm was observed after sputter depositing 60-nm-thick Ta films onto the oxygen-rich materials of native oxide of Si, SiO2, and porous MSQ. α-Ta with a much lower resistivity (∼35μΩcm) and an average grain size of ∼16nm was observed after sputter deposition of Ta onto a substrate with a 4-nm-thick hydrocarbon Pa-N film on porous MSQ. α-Ta was also formed when sputter depositing on the hydrocarbon BCB and SiLK low-κ dielectrics. The lattice constants of the α-Ta films were slightly larger (3.310–3.351 Å) than those of the bulk Ta (3.305 Å).
Induction of Prostaglandin Release from Macrophages by Bacterial Endotoxin (1999)

This review summarizes the role of the monocytic responses to lipopolysaccharide as it relates to periodontal disease severity. Data are presented which illustrate that the levels of prostaglandin E2 (PGE2) secreted by systemic peripheral blood monocytes in culture, in the presence of bacterial endotoxins, are highly correlated with the levels observed in the gingival crevicular fluid. Furthermore, the different periodontal diagnostic categories have varying levels of monocytic and crevicular fluid PGE2, in juxtaposition with clinical disease severity. These data are consistent with the concept that there is close synchrony between the systemic responsiveness of peripheral blood monocytes with regard to prostanoid synthesis and the local levels of mediator present within the gingival crevice.
MEASURING SPARSENESS OF NOISY SIGNALS (2003)

Blocking of TNF by etanercept enabled repair of osteochondral defects in rabbit knee. Anti-TNF therapy could be a strategy for the use of tissue engineering for bone and cartilage repair.
Immunological Study of the Heat-Labile Enterotoxins of <i>Escherichia coli</i> and <i>Vibrio cholerae</i> (1974)

Immunodiffusion experiments were conducted to associate a precipitin line with Escherichia coli heat-labile enterotoxin (LT). Wild strains of porcine and of human enteropathogenic E. coli as well as laboratory-derived enterotoxigenic variants of E. coli K-12 were used for LT antigen preparations. These were produced mainly by ultrafiltration and ammonium sulfate precipitation of broth culture supernatants. When antisera with anti-LT activity were reacted with antigen preparations from Ent(+) and Ent(-) variants of E. coli K-12, a line "a" was given by Ent(+) but not by Ent(-) preparations. Line "a" was removed by absorption of anti-LT serum with antigen preparation from an Ent(+)E. coli K-12, but was unaffected when the antigen preparation used to absorb the serum was from an Ent(-)E. coli K-12. A line identical to "a" was given by antigen preparations from wild strains of porcine enteropathogenic E. coli reacted with homologous or heterologous anti-LT sera. One human strain of enteropathogenic E. coli was shown to possess an antigen identical to that which gave rise to line "a." To demonstrate this line it was necessary to use high concentrations of gammaglobulin and high concentrations of the crude antigen preparations. LT preparations reacted with anticholera toxin to give a line "c," which showed a reaction of partial identity with line "b" produced by reaction of pure choleragenoid and anticholera toxin. Lines "a" and "c" gave reactions of identity.