gebhart/patrepeval huggingface dataset:
Transport of Metallic Ions through Polyaniline-Containing Composite Membranes (2010)

The extraction of Na+, Ni2+, and Cr3+ using six different membranes made of polyaniline composited with high-impact polystyrene, which differ in the doping agent and/or the preparation method, has been investigated. The swelling and ion-exchange capacities of the six polyaniline composited with high-impact polysterene (HIPS/PAni) membranes have been determined and compared with that of the commercial Selemion membrane. Electrodialysis tests using a five-compartment cell evidenced that the extraction of ions depends on the electronic structure of the SO3− groups, which is modulated by the doping agent, and on both microstructure and electrical resistance of the membrane, which are regulated by the preparation method. The transport of ions through HIPS/PAni and Selemion membranes was found to be comparable. Quantum mechanical calculations on model complexes have been performed to characterize the electronic structure of the dopants. Results indicate that the strength of the interaction between the different doping agents and the polyaniline is inversely proportional to the concentration of negative charge in the SO3− group of the former. Moreover, both the binding energy and the distribution of charges calculated for dopant···PAni complexes have been compared with those predicted for dopant···metallic ion complexes.
Elevated Levels of Thioredoxin 1 in the Lungs and Sera of Idiopathic Pulmonary Fibrosis, Non-Specific Interstitial Pneumonia and Cryptogenic Organizing Pneumonia (2010)

Overproduction of TRX1 in the lungs and sera may play an important role in the pathogenesis of IIPs.
Carbon nano-onions for supercapacitor electrodes: recent developments and applications (2013)

This critical review covers the use of carbon nano-onion (CNO) based materials for electrochemical capacitor (EC) electrodes. The performance of CNO capacitors is reviewed in detail and compared to the results obtained using different carbon nanostructures. The physico-chemical vs. electrochemical properties of CNOs are discussed. Their advantages, challenges and applications, especially in EC electrodes, are discussed in detail through an extensive analysis of the literature. Exohedral carbon nano-onions are much less limited by mass transfer kinetics; they show low resistance and can operate over a wide voltage and temperature window, at very high charge–discharge rates with almost unlimited cyclabilities. Although carbon nano-onions make excellent supercapacitor electrode materials, many challenges still remain, particularly to characterize and understand the physical, chemical, and electrochemical interactions within multicomponent systems that contain CNOs. The full potential of carbon nano-onions as electrochemical power sources has not been realized yet, but as outlined in this review, the future looks very promising.
Computing with DNA (1995)

We consider molecular models for computing and derive a DNA-based mechanism for solving intractable problems through massive parallelism. In principle, such methods might reduce the effort needed to solve otherwise difficult tasks, such as factoring large numbers, a computationally intensive task whose intractability forms the basis for much of modern cryptography.
Annotating the semantic web using natural language (2002)

Because the ultimate purpose of the Semantic Web is to help users better locate, organize, and process content, we believe that it should be grounded in the information access method humans are most comfortable with---natural language. However, the Resource Description Framework (RDF), the foundation of the Semantic Web, was designed to be easily processed by computers, not humans. To render RDF more friendly to humans, we propose to augment it with natural language annotations, or metadata written in everyday language. We argue that natural language annotations, parsed into computer-readable representations, are not only intuitive and effective, but can also accelerate the pace with which the Semantic Web is being adopted. We believe that our technology can facilitate a happy marriage between natural language technology and the Semantic Web vision.
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana (2009)

H3K4me plays widespread roles in regulating gene expression in plants. Although many aspects of the mechanisms and functions of H3K4me appear to be conserved among all three kingdoms, we observed significant differences in the relationship between H3K4me and transcription or other epigenetic pathways in plants and mammals.
Building detection in very high resolution multispectral data with deep learning features (2015)

The automated man-made object detection and building extraction from single satellite images is, still, one of the most challenging tasks for various urban planning and monitoring engineering applications. To this end, in this paper we propose an automated building detection framework from very high resolution remote sensing data based on deep convolutional neural networks. The core of the developed method is based on a supervised classification procedure employing a very large training dataset. An MRF model is then responsible for obtaining the optimal labels regarding the detection of scene buildings. The experimental results and the performed quantitative validation indicate the quite promising potentials of the developed approach.
Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity (1996)

Clinical and pathological features of 52 infants and children with atypical teratoid/rhabdoid tumor (ATT/RhT) of the central nervous system are defined. This tumor is typically misdiagnosed as a primitive neuroectodermal tumor (PNET) primarily because 70% of ATT/RhTs contain fields indistinguishable from classic PNETs. Separation of these two tumor types is crucial because the prognosis for ATT/RhT is given even when treatment includes surgery with or without radio and/or chemotherapy. These tumors are most common in infants less than 2 years of age. The cases described in this study arose in intracranially in all but one instance, although one-third had already spread throughout the subarachnoid space at presentation. Clinical signs and symptoms and radiological features do not distinguish ATT/RhTs from PNETs. The tumors are composed entirely (13%) or partly (77%) or rhabdoid cells. Seventy percent contains fields of typical PNET alone or in combinations with mesenchymal and/r epithelial elements. The immunohistochemical profile is unique: epithelial membrane antigen, vimentin, and smooth-muscle actin are positive in the majority of tumors and markers for germ-cell tumors are consistently negative. Abnormalities of chromosome 22 distinguish ATT/RhTs from PNETs, which typically display an i(17q) abnormality.
Basic c.c.d. logic gates (1980)

The basic logic elements of AND, OR and INVERTER gates as implemented in c.c.d. logic are described and experimentally evaluated. The AND and OR gates are incorporated in one simple structure using the mechanism of charge spillage over a d.c. control gate from a common input well. Design equations are presented for the floating-gate master-slave sensing structure which is the basis of the inverter and are shown to be in good agreement with practical results. The problems associated with the devices, namely speed of operation and chargetorage under the slave, are discussed in detail.
Basidiomatal formation of Antrodia cinnamomea on artificial agar media (2005)

Basidiomes of Antrodia cinnamomea are used as a traditional medicine in Taiwan. Because fungal basidiomes are so rare and attempts to cultivate them have failed, the price they command in the marketplace is exorbitant. Here, one dikaryotic isolate from a pairing between two compatible monokaryons obtained from two different basidiomes was able to produce basidiomes on PDA and MEA media at temperatures of 20-28°C within 45 days of incubation. The basidia and basidiospores produced on the hymenial layer were microscopically observed.
Streptoquin and Septazole: Antibiotic Drugs as CorrosionInhibitors for Copper in Aqueous Solutions (2014)

The inhibiting effect of streptoquin and septazole towards the corrosion of the copper in 0.1M of HCl solution has been studied by potentiodynamic polarization measurements, electrochemical impedance spectroscopy (EIS) and Electrochemical frequency modulation technique (EFM). Potentiodynamic polarization curves indicted that these compounds behave as mixed-type inhibitors. These drugs were adsorbed on copper surface follow Langmuir adsorption isotherm. The results obtained from EIS and EFM are in good agreement with potentiodynamic polarization measurements. Some quantum chemical parameters were calculated and compared with the experimental data.
Bioactive Polyketides from <i>Peperomia </i><i>duclouxii</i> (2007)

Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii. The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A and oleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 values that ranged from 4.4 to 9.6 microg/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calcein accumulation than verapamil at 2.5 and 25 microg/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderate to weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1alpha or TNF-alpha.
Dynamic model of micropipettes in piezo-assisted ICSI (2012)

In this paper, the full nonlinear equations of motion of an immersed glass micropipette driven longitudinally by a piezoelectric actuator are derived, based on Kane's method. The Morison equation is adopted to model the hydrodynamic forces in which the drag force is approximated with a viscous damping force. The model presented shows that the longitudinal vibration of a micropipette results in excitation of its out-of-plane, lateral eigenmodes. The nonlinear dynamic model is in good agreement with experimental observations in the literature. Furthermore, an immersed glass micropipette with imbedded mercury is also considered. Simulation results show that the lateral deflection of a micropipette tip increases by adding mercury. This result, however, is inconsistent with the experimental results. The discrepancy is possibly attributed to the assumption of zero relative motion between the mercury contained in the glass micropipette and the glass micropipette. Consequently, it is suggested that a more general nonlinear dynamic model should include the dynamic coupling effects of mercury due to its motion within the micropipette, as it vibrates longitudinally.
Augmented Curation of Clinical Notes from a Massive EHR System Reveals Symptoms of Impending COVID-19 Diagnosis (2020)

Understanding temporal dynamics of COVID-19 patient symptoms could provide fine-grained resolution to guide clinical decision-making. Here, we use deep neural networks over an institution-wide platform for the augmented curation of clinical notes from 77,167 patients subjected to COVID-19 PCR testing. By contrasting Electronic Health Record (EHR)-derived symptoms of COVID-19-positive (COVID pos ; n=2,317) versus COVID-19-negative (COVID neg ; n=74,850) patients for the week preceding the PCR testing date, we identify anosmia/dysgeusia (27.1-fold), fever/chills (2.6-fold), respiratory difficulty (2.2-fold), cough (2.2-fold), myalgia/arthralgia (2-fold), and diarrhea (1.4-fold) as significantly amplified in COVID pos over COVID neg patients. The combination of cough and fever/chills has 4.2-fold amplification in COVID pos patients during the week prior to PCR testing, and along with anosmia/dysgeusia, constitutes the earliest EHR-derived signature of COVID-19. This study introduces an Augmented Intelligence platform for the real-time synthesis of institutional biomedical knowledge. The platform holds tremendous potential for scaling up curation throughput, thus enabling EHR-powered early disease diagnosis.
A Systematic Approach on Data Pre-processing In Data Mining (2013)

Data pre-processing is an important and critical step in the data mining process and it has a huge impact on the success of a data mining Soil classification. Data pre-processing is a first step of the Knowledge discovery in databases (KDD) process that reduces the complexity of the data and offers better analysis and ANN training. Based on the collected data from the field as well soil testing laboratory, data analysis is performed more accurately and efficiently. Data pre-processing is challenging and tedious task as it involves extensive manual effort and time in developing the data operation scripts. There are a number of different tools and methods used for pre-processing, including: sampling, which selects a representative subset from a large population of data; transformation, which manipulates raw data to produce a single input; denoising, which removes noise from data; normalization, which organizes data for more efficient access; and feature extraction, which pulls out specified data that is significant in some particular context. Pre-processing technique for soil data sets are also useful for classification in data mining.
A new polysilicon process for a bipolar device&#8212;PSA technology (1979)

A new polysilicon process has been developed to obtain high packing density, high speed, and low-power LSI's. The new process, called the polysilicon self-aligned (PSA) method is based on a new fabrication concept for dimensional reduction and does not require fine patterning and accurate mask alignment. For an application example of this new method, an emitter-coupled logic (ECL) gate with 0.6 ns delay time, 0.5 pJ power-delay product, and 6400 µm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> gate area has been achieved. Futhermore, by introducing a polysilicon diode (PSD) and Schottky barrier diode (SBD) to the PSA method, a low-power Schottky-diode-transistor-logic (SDTL) gate with 1.6 ns delay time, 0.8 pJ power-delay product, and 2000-µm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> gate area has been successfully developed.
Formal Verification of Abstract System and Protocol Specifications (2006)

Formal methods such as automated model checking are used commercially for digital circuit design verification. These techniques find errors early in the product cycle, which improves development time and cost. By contrast, the current practice in complex system design is to specify system functions and protocol details in natural language. Some errors are found early by manual inspections, but others are only revealed during implementation testing or by costly field failures. We describe our application of formal specification and model checking to real telecom product development, and enumerate the classes of specification errors that these formal techniques revealed at an early stage of the development cycle
Tumor promoters induce a specific morphological signature in the nuclear matrix-intermediate filament scaffold of Madin-Darby canine kidney (MDCK) cell colonies. (1984)

Tumor promoters such as phorbol 12-tetradecanoate 13-acetate (TPA), mezerein, teleocidin, aplysiatoxin, and benzoyl peroxide, although structurally unrelated, induce similar, profound changes in morphology in differentiated epithelial Madin-Darby canine kidney (MDCK) cell colonies. The alteration is evident in the organization of intermediate filaments in intact cells and in whole mounts of the nuclear matrix-intermediate filament (NM-IF) scaffold of the epithelial sheet. This substructure, obtained by salt extraction of the cytoskeletal framework, represents only 5% of the total cell protein but contains all of the intermediate filaments, nuclear matrix, and desmosomal core proteins arranged essentially as in the intact cell. The NM-IF is profoundly reorganized after exposure to TPA and retains the morphological changes observed in intact cells. These include bundling of the intermediate filaments, disruption of cell-cell borders, and marked deformation of the polygonal geometry of epithelia. Thus, TPA and all other complete or second-stage tumor promoters examined have a characteristic morphological signature that is not induced by mitogens, metabolic inhibitors, or agents known to disrupt microtubules or microfilaments. This signature, characteristic of tumor promoters, occurs in the absence of both protein and RNA synthesis. These results suggest that this response is prior to and independent of other biochemical markers for tumor promoters. Of the major filament systems, the cytokeratin network is implicated as an early or possibly primary site of tumor-promoter action because characteristics of the promoted cytoskeletal signature are observed in epithelial colonies after prior exposure to colchicine or cytochalasin D. Despite the massive reorganization of cytoskeletal morphology induced by TPA, the distribution of prelabeled proteins into structural fractions (i.e., cytoskeletal, chromatin, and the NM-IF) remains essentially unchanged. The sensitivity and specificity of the epithelial cell response suggest its possible use as a screen for promoting compounds.
A theoretical and experimental investigation of explicit force control strategies for manipulators (1993)

This paper presents a complete overview of basic strategies that have been proposed for force control of robot manipulators. First, the model of the plant to be controlled is reviewed. Next, the strategies are divided into force-based and position-based categories, according to previously reported implementations. Each of the controller types within these categories is analyzed, and predictions of stability and efficacy are made. Then it is shown that these two categories are actually the same, and this recognition leads to the concept of a novel second order low pass filter controller. Finally, all of the controllers are experimentally tested on the CMU DD Arm II, confirming the theoretical predictions. Among the important results presented is the conclusive demonstration for the first time that integral gain control is the best basic strategy for force control of manipulators.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Variation of Acceptability of. Colour Prints with Spectral Sensitivities of Colour Negative Film and Colour Temperature of the Exposing Source (1992)

Two daylight-balanced colour negative films, one professional and one amateur product, have been exposed to a standard subject using approximately Planckian light sources with a wide range of colour temperatures. Prints have been made to achieve a standard grey reproduction from each negative and have also been prepared using a commercial automatic printer calibrated with the negative, in each set, exposed using professional electronic flash. Subjective investigations of print acceptability are used to investigate the influence of the different spectral sensitivity distributions of the two negative films. Print acceptability is also related to a Colour Reproduction Index calculated from the standard subject, using the Hunt colour appearance model. Conclusions are drawn concerning the applicability of different subjective techniques in determining print acceptability, the effect of negative sensitivities and the applicability of the Hunt colour appearance model to problems of print acceptability.
<i>In Vivo</i> Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice (2017)

PC945 is a novel triazole optimized for lung delivery, and the objective of this study is to determine the effects of intranasally dosed PC945 on <i>Aspergillus fumigatus</i> infection and associated biomarkers in immunocompromised mice. PC945, posaconazole, or voriconazole was administered intranasally once daily on days 0 to 3 (early intervention) or days 1 to 3 (late intervention) postinfection in temporarily neutropenic A/J mice infected intranasally with <i>A. fumigatus</i>, and bronchoalveolar lavage fluid (BALF) and serum were collected on day 3. The effects of extended prophylaxis treatment (daily from days -7 to +3 or days -7 to 0) were also compared with those of the shorter treatment regimens (days -1 to +3 or days -1 and 0). Early and late interventions with PC945 (2.8 to 350 μg/mouse; approximately 0.11 to ∼14 mg/kg of body weight) were found to inhibit lung fungal loads and to decrease the concentrations of galactomannan (GM) in both BALF and serum as well as several biomarkers in BALF (interferon gamma [IFN-γ], interleukin-17 [IL-17], and malondialdehyde) and serum (tumor necrosis factor alpha [TNF-α] and IL-6) in a dose-dependent manner and were >3- and >47-fold more potent than intranasally dosed posaconazole and voriconazole, respectively. Furthermore, extended prophylaxis with low-dose PC945 (0.56 μg/mouse; 0.022 mg/kg) was found to inhibit fungal loads and to decrease the concentrations biomarkers more potently than did the shorter treatment regimens. Thus, PC945 dosed intranasally once daily showed potent antifungal effects, and the effects of PC945 accumulated upon repeat dosing and were persistent. Therefore, PC945 has the potential to be a novel inhaled therapy for the treatment of <i>A. fumigatus</i> infection in humans.
The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the Epidermal Growth Factor Receptor (2013)

Activation of the epidermal growth factor receptor (EGFR) results in internalization and ubiquitin-dependent endosomal sorting, leading to lysosomal degradation. Here we describe the role of the RING-finger-domain-containing protein RNF126 and the related protein, Rabring7 in EGFR endosomal sorting. We demonstrate that RNF126 specifies K48-linked chains with UbcH5b and also functions with Ubc13/Uev1a to form K63-linked chains in vitro. RNF126 and Rabring7 associate with the EGFR through a ubiquitin-binding zinc finger domain and both E3 ubiquitin ligases promote ubiquitylation of EGFR. In the absence of c-Cbl or in cells expressing Cbl-70Z, the binding of RNF126 and Rabring7 to the EGFR is reduced, suggesting that RNF126 and Rabring7 function downstream of c-Cbl. In HeLa cells depleted of either RNF126 or Rabring7 the EGFR is retained in a late endocytic compartment and is inefficiently degraded. In addition, depletion of RNF126 or Rabring7 destabilizes ESCRT-II and reduces the number of multivesicular bodies formed after EGF stimulation. We also show that the depletion of Rabring7 attenuates the degradation of MET and that both RNF126 and Rabring7 regulate the sorting of CXCR4 from an early endocytic compartment. Together these data suggest that RNF126 and Rabring7 play a role in the ubiquitin-dependent sorting and downregulation of membrane receptors.
ChemInform Abstract: The Formation of Black Patina on Copper in Humid Air Containing Traces of SO2. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.