gebhart/patrepeval huggingface dataset:
p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells (2007)

Recent studies have shown that silibinin induces p21/Cip1 and p27/Kip1 and G1 arrest in different prostate cancer cells irrespective of p53 status; however, biological significance and mechanism of such induction have not been studied. Here, using two different prostate cancer cell lines DU145 and 22Rv1, representing androgen-independent and androgen-dependent stages of malignancy, first we investigated the importance of p21 and p27 induction in silibinin-mediated G1 arrest. Silencing p21 and p27 individually by RNA interference showed marked reversal in G1 arrest; however, their simultaneous ablation showed additional reversal of G1 arrest in 22Rv1 but not DU145 cells. These results suggest that whereas relative importance of these molecules might be cell line specific, their induction by silibinin is essential for its G1 arrest effect. Next, studies were done to examine mechanisms of their induction where cycloheximide-chase experiments showed that silibinin increases p21 and p27 protein half-life. This effect was accompanied by strong reduction in Skp2 level and its binding with p21 and p27 together with strong decrease in phosphorylated Thr(187) p27 without considerable change in proteasomal activity, suggesting a posttranslational mechanism. Skp2 role was further elucidated using Skp2-small interfering RNA-transfected cells, where decreased G1 arrest and attenuated Cip/Kip induction were observed with silibinin treatment. Further, silibinin caused a marked increase in p21 and p27 mRNA levels together with an increase in their promoter activity, also indicating a transcriptional mechanism. Together, our results for the first time identify a central role of p21 and p27 induction and their regulatory mechanism in silibinin-mediated cell cycle arrest.
Human Hepatocyte Transplantation: Worldwide Results (2006)

The conception and animal modeling of hepatocyte transplantation along with a partial listing of human hepatocyte infusions over the last 13 years have been detailed in authoritative reviews. However, to adequately best represent the worldwide effort of moving from highly successful clinical solid liver transplants "back to" isolated hepatocyte therapy requires repeating important concepts with explanations of how or why not animal experimental data translate to human experience. This overview summarizes 78 human clinical hepatocyte transplant experiences authenticated by the authors. The human cell infusion experiences are categorized by liver disease treated (metabolic, chronic, and acute liver failure), and these are accompanied by seminal in vitro and in vivo experimental data.
Asynchronous track fusion revisited (2002)

Recently the authors derived an asynchronous track fusion algorithm that combines tracks provided by different sensors with different sampling rates and communication delays (A.T. Alouani and T.R. Rice, 1996). In that algorithm, its dynamics propagates between updates, then it uses the tracks provided by the local processors (LPs) to update its track. The paper deals with the same problem except that the new fusion algorithm uses only the local tracks. No propagation of dynamics needs to be done by the fusion center.
Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: anti-inflammatory and anticholinesterasic activities (2005)

Combretum leprosum Mart. & Eicher (Combretaceae) leaves and roots ethanolic extracts were investigated by HRGC-MS and showed mono- and oligosaccharides, fatty acids and triterpenes as major compounds after derivatization with BSTFA/ TMCS. Arjunolic acid (1) was quantified on dried roots ethanolic extract (65%) by external standard. Anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities were observed for roots ethanolic extract of C. leprosum and arjunolic acid, suggesting both as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
Pulsed Laser Interference Patterning of Metallic Thin Films (2012)

Pulsed laser interference is applied to metallic and semiconductor thin films in the thickness range of 40-100 nm. At intensities which induce local melting we can observe local retraction of the molten material towards the unmolten areas due to dewetting. Thus micropatterning of surface gets feasible. Although this dewetting induced retraction should be a common behaviour of metals on oxide surfaces, two groups of materials can be distinguished. In the first group the former molten areas get completely blank of metal while in the second group a material droplet remains in the center of the molten area. We show that this behaviour can be attributed to a distinctly different way of liquid movement upon local melting.
The Strength of a Smile: Duchenne Smiles Improve Advertisement and Product Evaluations (2011)

Consumer research recognizes the well-established effect of positive emotions on consumers, i.e. consumers in positive moods tend to give positive evaluations of products and advertisements. Recently, researchers have investigated the use of Duchenne smiles (genuine smiles) in advertisements to evoke positive emotions and lead to positive evaluations. Duchenne smiles are identified by the activation of both the zygomaticus major muscle (which pulls up the corners of the mouth) and the orbicularis oculi muscles (which surround the eye and result in the crow’s feet wrinkles). Peace, Miles, and Johnston (2006) demonstrated that including Duchenne smiles in mock print advertisements affects viewers’ perceptions of the ad and featured product, resulting in more positive evaluations as compared to neutral and non-Duchenne advertisements. The current research expands on Peace et al. and examines the effects of type of smile displayed in mock print advertisements that feature inexpensive and expensive products alike. Participants rated pairs of advertisements created by the researchers. Participants significantly preferred Duchenne smiling advertisements over non Duchenne and also showed significant preference in their likelihood to purchase products in Duchenne advertisements. A potential mimicry association mechanism is discussed, as well as practical implications for advertisers.
Language modeling for content extraction in human-computer dialogues (1998)

In this paper we discuss the role of language modeling in a novel natural language dialogue system designed to automatically route incoming customer calls. We arrive at two significant conclusions: First, standard word error rate measures do not reflect application specific requirements; highly reliable content extraction is possible with relatively high word error rates. Secondly blending human-human data with human-machine data did not improve the performance in language modeling.
Solubility of Carbon Dioxide in Aqueous Mixtures of Alkanolamines (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Carbon Dioxide in Aqueous Mixtures of AlkanolaminesOlukayode Fatai Dawodu and Axel MeisenCite this: J. Chem. Eng. Data 1994, 39, 3, 548–552Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/je00015a034https://doi.org/10.1021/je00015a034research-articleACS PublicationsRequest reuse permissionsArticle Views973Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
“Go With the Flow”: How Krüppel-Like Factor 2 Regulates the Vasoprotective Effects of Shear Stress (2010)

Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Krüppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Krüppel-like factor 2 action in endothelial gene expression and function.
Speed-efficient wide adders for VIRTEX FPGAs (2003)

Recently, reconfigurable hardware based on field programmable gate arrays (FPGAs) has been presented as a promising alternative for implementing cryptographic systems. One of the main limitations of this approach, with respect to ASIC realizations, is the relatively low reachable throughput because of arithmetic operators, such as adders and multipliers, with large operands. In this paper, an efficient addition scheme designed for VIRTEX FPGAs is presented that outperforms the commonly used Macro-generated ripple-carry scheme for the case in which long words have to be added. The proposed method uses appropriately placed by-pass elements to eliminate consistent routing delays from critical paths. A 128 bit adder realized as described here shows a gain in speed of up to 47% with respect to a conventional adder with an increase of just 28% in area occupancy.
Long-time electron spin storage via dynamical suppression of hyperfine-induced decoherence in a quantum dot (2008)

The coherence time of an electron spin decohered by the nuclear spin environment in a quantum dot can be substantially increased by subjecting the electron to suitable dynamical decoupling sequences. We analyze the performance of high-level decoupling protocols by using a combination of analytical and exact numerical methods, and by paying special attention to the regimes of large interpulse delays and long-time dynamics, which are outside the reach of standard average Hamiltonian theory descriptions. We demonstrate that dynamical decoupling can remain efficient far beyond its formal domain of applicability, and find that a protocol exploiting concatenated design provides best performance for this system in the relevant parameter range. In situations where the initial electron state is known, protocols able to completely freeze decoherence at long times are constructed and characterized. The impact of system and control nonidealities is also assessed, including the effect of intrabath dipolar interaction, magnetic field bias and bath polarization, as well as systematic pulse imperfections. While small bias field and small bath polarization degrade the decoupling fidelity, enhanced performance and temporal modulation result from strong applied fields and high polarizations. Overall, we find that if the relative errors of the control pulse flip angles do not exceed 3%, decoupling protocols can still prolong the coherence time by up to 2 orders of magnitude.
Erythroid-restricted expression of homeobox genes of the human HOX 2 locus (1991)

Abstract We have previously reported that certain members of the HOX 1 and HOX 2 clusters of class 1 homeobox-containing genes showed lineage-restricted patterns of expression in a small series of human hematopoietic cell lines. We now report on the expression patterns of the entire HOX 2 cluster, consisting of nine homeobox genes, in a broad survey of leukemic cell lines of different phenotypes. The most striking observation is that all but one of the HOX 2 genes are consistently expressed in cells with erythroid character and/or potential, but, with rare exception, not in cells with myelomonocytic or T- or B-lymphoid phenotype. By contrast, several genes of the HOX 1 and 3 loci are not expressed in erythroid lines. Within erythroid cell lines, many of the HOX 2 genes are expressed as multiple transcripts. Expression of some HOX 2 genes is detectable in normal human marrow. These data show that in human hematopoietic cell lines HOX 2 homeobox gene expression is largely restricted to cells of erythroid phenotype and suggest that these genes play a role in erythropoiesis.
Efficient Detection of Zero-day Android Malware Using Normalized Bernoulli Naive Bayes (2015)

According to a recent F-Secure report, 97% of mobile malware is designed for the Android platform which has a growing number of consumers. In order to protect consumers from downloading malicious applications, there should be an effective system of malware classification that can detect previously unseen viruses. In this paper, we present a scalable and highly accurate method for malware classification based on features extracted from Android application package (APK) files. We explored several techniques for tackling independence assumptions in Naive Bayes and proposed Normalized Bernoulli Naive Bayes classifier that resulted in an improved class separation and higher accuracy. We conducted a set of experiments on an up-to-date large dataset of APKs provided by F-Secure and achieved 0.1% false positive rate with overall accuracy of 91%.
Innovative Color Interpolation Using Fuzzy Logic and Linear Regression (2005)

To reduce the cost of digital cameras, the color filter array (CFA) is usually coated upon a single-chip image sensor. Each pixel of the image sensor can sense only one of the R, G and B colors under CFA. The two missing colors of a pixel are estimated using the CFA interpolation algorithm. The interpolation algorithm may generate color distortion and degrade the quality of interpolated images. In this paper, we propose a new algorithm “fuzzy logic and linear regression method (FLLRM)” to solve this problem.We use fuzzy logic method based on the effect between pixels to avoid color distortion around the edges. The linear regression method is used to process the interaction effect among R, G and B channels. The proposed method can successfully eliminate false color, color moire, aliasing and color shifts in the full color camera output. Finally, we implement our method on the digital camera platform that is designed by Industrial Technology Research Institute (ITRI). The processed image shows a very good quality, which also demonstrates our approach is a better CFA interpolation algorithm than the previous processed methods.
Parabolic pulse generation in comb-like profiled dispersion decreasing fibre (2006)

Parabolic pulse generation around 1550 nm in dispersion decreasing comb-like profiled fibre is experimentally demonstrated. A six-segment comb profile based on two types of highly nonlinear fibre with normal dispersion is used to reshape 190 fs pulses into 540 fs linearly chirped parabolic pulses after a propagation distance of only 1.7 m. Frequency resolved optical gating is used to measure the output pulse intensity and chirp, and the experimental results are in good quantitative agreement with numerical simulations.
<title>Model-based 3-D segmentation of multiple sclerosis lesions in dual-echo MRI data</title> (1992)

This paper describes the development and use of a brain tissue probability model for the segmentation of multiple sclerosis lesions in magnetic resonance (MR) images of the human brain. Based on MR data obtained from a group of healthy volunteers, the model was constructed to provide prior probabilities of grey matter, white matter, ventricular cerebrospinal fluid (CSF), and external CSF distribution per unit voxel in a standardized 3- dimensional `brain space.' In comparison to purely data-driven segmentation, the use of the model to guide the segmentation of multiple sclerosis lesions reduced the volume of false positive lesions by 50%.
Prevention of Stone Migration with the Accordion During Endoscopic Ureteral Lithotripsy (2011)

The Accordion device is effective in preventing the migration of stone fragments during endoscopic ureteral lithotripsy. Our data suggest that this device may also increase efficiency of the fragmentation and clearance of ureteral calculi.
Spectral quality of light modulates emotional brain responses in humans (2010)

Light therapy can be an effective treatment for mood disorders, suggesting that light is able to affect mood state in the long term. As a first step to understand this effect, we hypothesized that light might also acutely influence emotion and tested whether short exposures to light modulate emotional brain responses. During functional magnetic resonance imaging, 17 healthy volunteers listened to emotional and neutral vocal stimuli while being exposed to alternating 40-s periods of blue or green ambient light. Blue (relative to green) light increased responses to emotional stimuli in the voice area of the temporal cortex and in the hippocampus. During emotional processing, the functional connectivity between the voice area, the amygdala, and the hypothalamus was selectively enhanced in the context of blue illumination, which shows that responses to emotional stimulation in the hypothalamus and amygdala are influenced by both the decoding of vocal information in the voice area and the spectral quality of ambient light. These results demonstrate the acute influence of light and its spectral quality on emotional brain processing and identify a unique network merging affective and ambient light information.
A Synthesis of Poly(2,4-Perfluoroalkylene-6-Perfluoroalkyltriazine)S (1966)

Abstract By thermal cyclodeamination reactions, perfluoroalkyleneimidines and perfluoroalkylamidines have been polymerized to give crosslinked triazine compositions. This reaction involves condensation of the reactants with elimination of ammonia and is illustrated in the formation of I. The amidines and imidines were prepared by the facile addition of ammonia to perfluoroalkane nitriles. Where the mono- and difunctional reactants were of comparable reactivity, essentially random condensations occurred so that gelled polymers were obtained. Properties of these gels varied, depending upon the reactant ratios used, from rather weak, gummy material to tougher inelastic polymers. Tensile strengths observed with these polymers generally ranged from 100 to 500 psi at about 100 per cent elongation. The triazine gels exhibited interesting thermal stability, showing no rapid decomposition up to 420° C; it was thought that with the discovery of a synthesis which would give linear, ungelled, triazine polymer that polymers having improved physical properties might be obtained.
A Novel Micro Mobility Solution Based on Media Independent Handover and SIP (2006)

Media Independent Handover (MIH) is a technique proposed by the emerging IEEE 802.21 standard that provides solutions for seamless handover across heterogeneous networks. The IEEE standard provides link layer intelligence information to upper layer to optimize handover between networks of the same type as well as handover between different network types. Session Initiation Protocol (SIP) is becoming the leading protocol for multimedia call control in IP networks and is expected to be widely deployed in the near future. The existing SIP infrastructures and signalling could be optimized to provide a good solution for mobility support. In this paper we introduce the concept of MIH and propose a solution for vertical handover of a multimedia session based on SIP with the triggers being provided by MIH for efficient terminal mobility management in a SIP environment.
Proton NMR chemical shifts and coupling constants for brain metabolites (2000)

Proton NMR chemical shift and J-coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain. Measurements were obtained using high-field NMR spectra of metabolites in solution, under conditions typical for normal physiological temperature and pH. This information is presented with an accuracy that is suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure. This procedure is verified by the analysis of a rat brain extract spectrum, using the measured spectral parameters. In addition, the metabolite structures and example spectra are presented, and clinical applications and MR spectroscopic measurements of these metabolites are reviewed.
Glyceryl trinitrate treatment of chronic fissure in ano: one year's experience with 0.5% GTN paste. (2000)

The use of 0.5% GTN induces rapid healing of chronic anal fissures with a 73% healing rate in this study. Successful treatment may come at the expense of a high incidence of headaches and a lower compliance than found in studies involving a lower concentration of GTN. A balance is required between fissure healing and headache intolerance.
PHOSPHOLIPASE A<sub>2</sub> ACTIVITY OF GUINEA‐PIG ISOLATED PERFUSED LUNGS: STIMULATION, AND INHIBITION BY ANTI‐INFLAMMATORY STEROIDS (1978)

A simple double‐isotope assay for phospholipase A 2 activity of perfused organs is described. Guinea‐pig lungs perfused through the pulmonary circulation exhibit a low background enzyme activity. This activity is blocked by dexamethasone, betamethasone and hydrocortisone, mepacrine, procaine or chlorpromazine. Aspirin and indomethacin are without effect. Mechanical trauma, antigen challenge or injections of bradykinin, rabbit aorta contracting substance‐releasing factor (RCS‐RF) or histamine increase ‘basal’ phospholipase activity. The effect of these agents, except that of bradykinin, is blocked by dexamethasone or mepacrine. The blocking effect of steroids is cumulative and dose‐dependent. They do not work in cell‐free systems. Inhibition by mepacrine is rapid and is effective in cell‐free lung homogenates. It is suggested that agents which liberate prostaglandin endoperoxides and thromboxane A 2 from perfused lungs do so by activating phospholipase A 2 .
INSTRUMENTED FIELD TEST ON LIGHT EXPANDED CLAY AGGREGATE USED IN PAVEMENTS (2002)

Damages due to frost penetration into frost susceptible soil are a severe problem in the Nordic countries. Traditionally road construction materials like gravel and crushed rock have very low insulating capacity and quite thick layers are needed to avoid frost penetration. Light weight expanded clay aggregate (LWA) is a promising alternative because of its good insulating properties. This paper describes a research project initiated to investigate the mechanical and thermal properties of the LWA-material in pavement structures. The material has been studied in a laboratory by several tests, including repeated load triaxial testing. A full scale laboratory test was also performed with a real pavement structure built in the laboratory.
Superior Oxygen Ion Conductivity of Lanthanum Gallate Doped with Strontium and Magnesium (1996)

The solid solution range of the perovskite was investigated and the oxygen ion conductivities of corresponding compositions were measured. The solubility of strontium could be extended by the addition of magnesium ions to establish a balance in the oxygen vacancies associated with A and B sites. In this way, the Sr limit in the solid solution was increased to more than 20% of the La content. Doping with either Sr or Mg enhanced oxygen ion conductivity, but whereas Sr doping yielded decreased activation energy with increasing concentration, Mg produced a higher activation energy with increased Mg content. was found to have the highest conductivity apart from ‐based electrolytes at temperatures below 700°C, while has the highest conductivity except for at temperatures above 700°C.