gebhart/patrepeval huggingface dataset:
Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice. (1993)

Cartilage collagen fibrils, which are characterized by their thin, uniform diameters, are formed of a multicomponent system of three collagen types (II, IX, and XI) and interacting proteoglycans. We have used a genetic approach to test whether the proper assembly of this multiprotein structure was altered by overexpression of one of its normal components. Here we show that in transgenic mice in which the normal mouse alpha 1(II) collagen is overexpressed, thick abnormal collagen fibrils are generated. Mice that showed the highest expression of the transgene also displayed a larger proportion of abnormal fibrils and died at birth. We propose that an imbalance among the constituents of the cartilage collagen fibrils disrupts the mechanism that controls their assembly. The results show the applicability of the transgenic mice system to studies of complex multicomponent protein assemblies in intact animals.
New Additives to Improve the First-Cycle Charge–Discharge Performance of a Graphite Anode for Lithium-Ion Cells (2005)

We tested the effect of two new additives, cyclo hexane (CH) and 1-methyl-2-pyrrolidinone (NMP), on the cycling performance of a carbon-coated artificial graphite (AG) anode on a lithium-ion cell to investigate suppression of irreversible capacity loss of the graphite anode during the first-cycle charge. Both CH and NMP additives effectively increased the coulombic efficiency of the graphite anode during the first cycle. We attribute this phenomenon to the dissolution of the poly (vinylidene fluoride) (PVdF) binder of the AG anode due to CH or NMP addition, which improved the PVdF elasticity and reduced the contact area between the AG particles and the electrolyte. Consequently, adding CH or NMP reduced the loss of lithium ions in the first-cycle charge. Cycle-performance testing of the Li/AG half-cell indicated that we could achieve maximum discharge capacity and coulombic efficiency by applying an additive amount ranging from 2 to 5% for both CH and NMP. The cycling performance testing of the half-cell suggested that these two additives also have good oxidation stability and are therefore worth applying in lithium-ion cells with graphite anodes.
Real-Time Monitoring via Patch-Type Piezoelectric Force Sensors for Internet of Things Based Logistics (2017)

We propose the use of simple and low cost piezoelectric patch type force sensors for logistic applications to ensure safety of the package while also detecting damage suffered. The sensors are connected to a prototype readout system that can record the data and transfer it wirelessly via a Bluetooth module. The data can be received by an in-vehicle telematics device which can upload it directly to the cloud database, thus allowing real time monitoring of package condition during transportation. This logistics management model would aid in improving the quality of services provided by the logistics company while also earning consumer credibility. Thus, we believe that these patch type force sensors can be realistically implemented in logistics in the near future.
An Approach to Leak Detection in Pipe Networks Using Analysis of Monitored Pressure Values by Support Vector Machine (2009)

This paper presents a method of mining the data obtained by a collection of pressure sensors monitoring a pipe network to obtain information about the location and size of leaks in the network. This inverse engineering problem is effected by support vector machines (SVMs) which act as pattern recognisers. In this study the SVMs are trained and tested on data obtained from the EPANET hydraulic modelling system. Performance assessment of the SVM showed that leak size and location are both predicted with a reasonable degree of accuracy. The information obtained from this SVM analysis would be invaluable to water authorities in overcoming the ongoing problem of leak detection.
Pegylated Protein Encapsulated Multivesicular Liposomes: A Novel Approach for Sustained Release of Interferon α (2006)

Hepatitis C viral chemotherapy suffers from a relatively short half-life of the interferon alpha-2a (IFN alpha). To address this issue, we investigated the effects of polyethylene glycol modification and their subsequent encapsulation in multivesicular liposomes (MVLs), on the release properties of IFN alpha. In the present study, interferon-alpha was conjugated with methoxy-polyethylene glycol (mPEG, MW 5000). Prepared IFN alpha-mPEG5000 conjugate (IFN alpha-mPEG5000) was purified with size exclusion chromatography. The relative in vitro anti-viral activity of pegylated interferon alpha-2a was found to 87.9% of the unmodified IFN alpha. Pegylated IFN alpha encapsulated multivesicular liposomes were prepared by double emulsification technique followed by evaporation of organic solvents from chloroform ether spherules suspended in water. Prepared MVLs were then characterized for shape, size, vesicle count, encapsulation efficiency, and in vitro release rate. In process stability studies of pegylated IFN alpha protein exhibited better stability when exposed to chloroform: diethyl ether (1:1 ratio) mixture as well as variable vortexing time as compared to native IFN alpha. Relatively high percentage of encapsulation of protein ( approximately 75%) was achieved. In vitro release profile of pegylated IFN alpha-mPEG5000 containing MVLs in the PBS showed lower initial burst release with sustained and incomplete release over a period of 1 week. In contrast, native IFN alpha entrapped MVLs were observed as higher initial burst release, i.e., nearly 35% followed by almost complete release. The results confirmed the possibility of multivesicular liposomes as a long-acting or sustained-release delivery system using a combination of pegylation and encapsulation technique for controlled delivery of interferon alpha.
Inositol Phosphates and Derivatives (1991)

With the intense interest created by the inositol phospholipids a need has arisen for a review of the stereochemistry and nomenclature of their hydrolytic products, the myo-inositol phosphates. From elementary considerations of molecular geometry the concepts of conformation, configuration, chirality, and the meso compound are developed and how these concepts lead to a consistent nomenclature is explained. A new nomenclature applicable mainly to this family of compounds, including the adoption of the symbol Ins, is presented. These principles are examined in the light of enzymatic reactions of myo-inositol leading to chiral products and of published methods for the laboratory synthesis of chiral myo-inositol phosphates involved in second messenger function.
Strukturelle Charakterisierung einer trisagostischen Lanthanoid‐Si‐H‐Wechselwirkung (1996)

Alle tert‐Butylgruppen des (Amido)erbiumkomplexes [Er{N( t Bu)[Si(CH 3 ) 2 (H)]} 3 ] (Strukturbild rechts, zwei Amidoliganden sind weggelassen) befinden sich auf derselben Seite der N 3 ‐Ebene, alle Si‐CH 3 ‐Gruppen sind zur Peripherie der gegenüberliegenden Molekülhemisphäre gerichtet. Dies führt zu Er‐H‐Abständen von 231.7–236.7 pm für die sich zum Metallzentrum orientierenden Si‐H‐Einheiten. magnified image
Radical ions as chain carriers in polymerization reactions (1985)

Certain polymerization reactions show the formation of medium molecular weights at the beginning of the reaction, although they can be considered to be polycondensations. The principle of equal reactivity of the end groups is not given in this case. Intermediates more reactive than the monomer are formed during the reaction. Poly(oxy-2,6-dimethyl-l,4-phenylene), poly(l,4-phenylene sulfide) and poly(l,4-phenylene) are examples of this type of reaction. The formation of radical ions in these reactions is discussed and they are compared to Bunnett's SRN1-reactions.
POCT and Rapid Scale-Up of Centralized Laboratory Services in Zambia (2008)

s: Critical and Point-of-Care Testing: Managing Technology for the Benefit of All Populations: 22nd International Symposium: September 17-20, 2008: Catalonia Barcelona Plaza Hotel|Barcelona, Spain
Use of Antistaphylococcal  -Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding (2011)

We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.).
Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells (2011)

The forkhead box n1 (Foxn1) transcription factor is essential for thymic organogenesis during embryonic development; however, a functional role of Foxn1 in the postnatal thymus is less well understood. We developed Foxn1 transgenic mice (Foxn1Tg), in which overexpression of Foxn1 is driven by the human keratin-14 promoter. Expression of the Foxn1 transgene increased the endogenous Foxn1 levels. In aged mice, overexpression of Foxn1 in the thymus attenuated the decline in thymocyte numbers, prevented the decline in frequency of early thymic progenitors, and generated a higher number of signal joint TCR excised circle. Histologic studies revealed that structural alterations associated with thymic involution were diminished in aged Foxn1 Tg. Total numbers of EpCAM+ MHC II+ and MHC II(hi) thymic epithelial cells were higher in young and old Foxn1Tg and more EpCAM+ MHC II(hi) TEC expressed Ki-67 in aged Foxn1Tg compared with WT. Furthermore, Foxn1Tg displayed a significant reduction in the expansion of splenic CD4+ memory compartments and attenuated the decline in CD4+ and CD8+ naive compartments. Our data indicate that manipulation of Foxn1 expression in the thymus ameliorates thymopoiesis in aged mice and offer a strategy to combat the age-associated decline in naive T-cell production and CD4 naive/memory ratios in the elderly.
Coated wire ion-selective electrodes (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoated wire ion-selective electrodesHelen J. James, Gary. Carmack, and Henry. FreiserCite this: Anal. Chem. 1972, 44, 4, 856–857Publication Date (Print):April 1, 1972Publication History Published online1 May 2002Published inissue 1 April 1972https://pubs.acs.org/doi/10.1021/ac60312a046https://doi.org/10.1021/ac60312a046research-articleACS PublicationsRequest reuse permissionsArticle Views656Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The World Wide Web as a place to work in (2002)

We describe our concept of an active Web, namely how we design the software architecture of interactive cooperative applications based on the WWW. An active Web includes agents able to use the services offered by WWW clients and servers. In an active Web, both users and agents can interoperate using a set of basic services for communication and synchronization. The active Web we describe here is based on coordination technology: we explore two alternative implementations, one based on a platform called Paradise and another fully based on Java.
[Study on metabolism of pyridonecarboxylic acid. I. Isolation and identification of metabolites of (+-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1- (2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate (T-3262) in urine]. (1989)

Metabolism of (+-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4- oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate (T-3262) was studied. Metabolites were isolated from urine of mouse, rat, rabbit, dog and monkey following oral administration of T-3262, and identified using high performance liquid chromatography and mass spectrometry. Two metabolites, other than unchanged (+-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (T-3262 base), in which 3-aminopyrrolidinyl ring of T-3262 was metabolized, were identified as: (+-)-7-(3-acetyl-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro- 1,4- dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid (T-3262A) in all animals: (+-)-1-(2,4-difluorophenyl)-6-fluoro-7-(3-hydroxy-1-pyrrolidinyl)-1,4- dihydro- 4-oxo-1,8-naphthyridine-3-carboxylic acid (T-3262B) in monkey. The glucuronide of T-3262 was detected in mouse, dog and monkey, the glucuronides of T-3262A and T-3262B were detected in monkey. M-I, unidentified metabolite, was detected only in mouse.
NEGATIVE COMPLEMENTATION AT THE NOTCH LOCUS OF <i>DROSOPHILA MELANOGASTER</i> (1975)

Four Abruptex alleles (AxE1, AxE2, Ax9B2, and Ax16172) have been mapped within the Notch locus. Based on their visible phenotypes and their interactions with one another and with N mutations, the Ax alleles can be divided into two groups. Heterozygous combinations of members of the same group are intermediate in phenotype compared to the respective homozygotes, whereas heterozygotes of Ax alleles from different groups exhibit negative heterosis, being much less viable and more extremely mutant than either homozygote. It is suggested that the Notch locus is a multi-functional regulator ("integrator") gene, whose product possesses both "repressor" and "activator" functions for the processes it regulates.
Securing Management and Managing Security (2011)

This conclusion chapter presents a coverage of security systems design with a discussion of management and, more specifically the management of security. It presents an overview of modern network and infrastructure management as a context to the management of deployed security mechanisms. The chapter discusses the need for management to stay involved in security management activities. It also discusses the operational security, necessary mechanisms, including forensics, third-party access reviews, and certification. The chapter examines the treatment of security management with consideration of how to withdraw equipment from service without exposing information to unauthorized access. It considers the need for compliance relative to security policies that must be adhered to by operations and management personnel, and concludes with consideration of activities related to security when developing or purchasing functions, subsystems, or complete solutions. Controlled Vocabulary Terms computer network security
Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: changes in transferrin uptake, iron handling and ferritin mRNA (1993)

We have investigated the effects of the pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) on the iron metabolism of the human monocytic cell line U937. Cells were treated with each cytokine for up to 24 h, and then iron uptake from diferric transferrin was determined. The intracellular distribution of this iron, the expression of the transferrin receptor and levels of mRNA for the two ferritin subunits were also studied. IL-1 beta, TNF alpha and IFN gamma all decreased transferrin-iron uptake into cells, and all three cytokines had effects on the proportion of iron associated with ferritin. With TNF alpha there was a marked enhancement of the fraction incorporated into ferritin. Transferrin-receptor expression was diminished by TNF alpha and IL-1 beta, but not IFN gamma, suggesting different effector mechanisms. Both TNF alpha and IFN gamma increased the amount of cellular mRNA for ferritin H-chain, but not the L-chain; IL-1 beta affected mRNA for neither ferritin. These data demonstrate that cytokines, which can be present at high concentrations in inflammation, have the capacity to affect macrophage iron uptake, transferrin receptor expression, intracellular iron handling and the relative abundance of ferritin-subunit mRNA, and may therefore be important mediators in the observed perturbations of iron metabolism in inflammatory diseases.
Investigation of charge loss mechanisms IN 3D TANOS cylindrical junction-less charge trapping memory (2014)

This paper presents a detailed simulation analysis of the charge loss mechanisms in 3D TANOS cylindrical junction-less charge trapping memory devices. For the programmed state, the role of tunneling through the bottom oxide and top oxide in vertical charge loss were compared, and the latter is found to be the dominant component. It is also found that lateral charge migration shows dependence on the shape of charge trapping layer. And the winding charge trapping layer shows favorable lateral migration performance. Simulation results show that lateral charge migration is more severe rather than vertical charge loss and must be focused with decreasing memory cell size. The result will give an guidance for high density 3D memory design optimization.
Health‐related quality of life assessed before and during chemotherapy predicts for survival in multiple myeloma (1997)

Measurement of health-related quality of life was integrated into a randomized trial (NMSG 4/90) comparing melphalan/prednisone to melphalan/prednisone + interferon alpha-2b in newly diagnosed multiple myeloma. One of the aims of the study was to assess the prognostic significance of quality-of-life scores, using the EORTC QLQ-C30 questionnaire. Univariate analysis showed a highly significant association with survival from the start of therapy for physical functioning as well as role and cognitive functioning, global quality of life, fatigue and pain. In multivariate analysis, physical functioning and W.H.O. performance status were independent prognostic factors (P values = 0.001 for both) when analysed in a Cox regression model with the somatic variables beta-2 microglobulin, skeletal disease and age. The best prediction for survival from the start of therapy was obtained by combining the beta-2 microglobulin and physical functioning scores in a variable consisting of three risk factor levels with an estimated median survival of 17, 29 and 49 months, respectively. At a 12 months landmark analysis, the relative risk for patients with physical functioning score 0-20 v 80-100 was 5.63 (99% CI 2.76-11.49), whereas the relative risk for patients without an objective response to chemotherapy compared to those with at least a minor response was 2.32 (99% CI 1.44-3.74). Quality-of-life assessment may be an independent and valuable addition to the known prognostic factors in multiple myeloma.
Phage display selection can differentiate insecticidal activity of soybean cystatins (1998)

Plant cysteine proteinase inhibitors (phytocystatins) have been implicated as defensive molecules against Coleopteran and Hemipteran insect pests. Two soybean cystatins, soyacystatin N (scN) and soyacystatin L (scL), have 70% sequence identity but scN is a much more potent inhibitor of papain, vicilin peptidohydrolase and insect gut proteinases. When these cystatins were displayed on phage particles, papain-binding affinity and CPI activity of scN were substantially greater than those of scL, in direct correlation with their relative CPI activity as soluble recombinant proteins. Furthermore, scN substantially delayed cowpea weevil (Callosobruchus maculatus (F.)) growth and development in insect feeding bioassays, whereas scL was essentially inactive as an insecticide. Papain biopanning selection of phage-displayed soyacystatins resulted in a 200-1000-fold greater enrichment for scN relative to scL. These results establish that binding affinity of cystatins can be used in phage display biopanning procedures to select variants with greater insecticidal activity, illustrating the potential of phage display and biopanning selection for directed molecular evolution of biological activity of these plant defensive proteins.
Effects of hot spot hopping and drain ballasting in integrated vertical DMOS devices under TLP stress (2004)

The effects of hot spot hopping and drain ballasting are investigated in vertical DMOS devices under ESD stress. The frequency of the hot spot hopping between two neighboring channels of the device is shown to be dependent on the dose of the n-type buried layer (BLN). A correlation between the hopping frequency and the maximum average temperature of the device and hence its robustness under transmission line pulsing (TLP) testing, is found. The devices are analyzed using on-wafer TLP measurements and backside transient interferometric mapping experiments.
Editorial: Prostate Cancer-Educating Ourselves and Our Nonurological Colleagues (1996)

No AccessJournal of UrologyClinical Urology: Editorial1 Feb 1996Editorial: Prostate Cancer-Educating Ourselves and Our Nonurological Colleagues Alan W. Partin Alan W. PartinAlan W. Partin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66465-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial: Prostate Cancer-Educating Ourselves and Our Nonurological Colleagues." The Journal of Urology, 155(2), pp. 610–611 References 1 : Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med.1987; 317: 909. Google Scholar 2 : The clinical usefulness of prostate specific antigen: update 1994. J. Urol.1994; 152: 1358. Link, Google Scholar 3 : Random systemic versus directed ultrasound guided transrectal core biopsies of the prostate. J. Urol.1989; 142: 71. Abstract, Google Scholar 4 : Diagnosis of prostate cancer by transrectal ultrasound. Urol. Clin. N. Amer.1989; 16: 663. Google Scholar 5 : Editorial: perspectives on the problem of prostate cancer. J. Urol.1994; 152: 1680. part 2. Abstract, Google Scholar 6 : Indications for ultrasound guided transition zone biopsies in the detection of prostate cancer. J. Urol.1995; 153: 1000. part 2. Link, Google Scholar Department of Urology, The Johns Horpkins Hospital, Baltimore, Maryland.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 155Issue 2February 1996Page: 610-611 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Alan W. Partin More articles by this author Expand All Advertisement PDF downloadLoading ...