gebhart/patrepeval huggingface dataset:
Direct sequence CDMA power control, interleaving, and coding (1993)

The authors develop and analyze models of power control that consider other aspects of code-division multiple access (CDMA) systems, such as interleaving and coding on the land mobile radio channel. The orientation is that a power control scheme keeps the received powers at the base station almost equal, and the performance degradation incurred if the powers are not exactly equal will be quantified. In doing so, the authors consider the performance implications of control latency and a maximum speech delay constraint. Because of positive correlations between the fading channel amplitudes, the effectiveness of the combination of interleaving and coding in combating the effects of power variations due to slow Rayleigh fading is reduced. It is shown that power control and interleaving/coding are most effective in complementary parameter regions, thus providing a degree of robustness for both fast and slow Rayleigh fading.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A network-topology independent task allocation strategy for parallel computers (1990)

A network-topology, independent practical task allocation strategy has been designed and implemented for parallel computers. For mapping a task graph to a processor graph, this strategy evaluates several functions that represent some intuitively feasible properties of the graphs. Several strategies are defined to guide the mapping process, utilizing the indicated values.An allocation system has been designed and implemented based on this strategy. The experimental results indicate the following: 1) the system can yield 2.14 times better allocation than an arbitrary allocation, 2) it is difficult to select a single strategy capable of providing the best solutions for a wide range of task-processor combinations, and 3) the computation time of the allocator is reasonable.The effect of task and processor topology combinations on the allocation results is also discussed.
Pharmacology and treatment of neuropathic pains (2009)

Treating neuropathic pain remains a great challenge, and the treatment has to be individualized to the single patient, taking into account side effects, pain type, comorbidities, and drug interactions.
Biomechanical analysis of body mass transfer during stair ascent and descent of healthy subjects. (1993)

The purposes of this study were to: 1) assess whole body center of mass (CM) motion in the frontal, sagittal, and transverse planes; 2) compare CM displacement with center of pressure (CP); and, 3) further define the stance and swing subphases of stair ascent (SA) and stair descent (SD) based on critical CM, CP, and ground reaction force (GRF) events. SA and SD were analyzed on a convenience sample of 11 subjects. Unpaced data were collected from 28 SA trials and 24 SD trials utilizing a bilateral SELSPOT II/TRACK data acquisition system and two Kistler force plates at a sampling frequency of 153 Hz. Twenty-six discrete data points were chosen from each trial for analysis. Each identified point detailed the intersection, separation, maximum or minimum value of CM, CP, or GRF in all three planes. Specific phases of SA and SD are presented and described. The actions of CM, CP, and GRF are presented during each phase. Results further refine the phases originally described by McFayden and Winter. Subtle differences in phases and duration of single and double support are demonstrated between SA and SD. Based on these results, it is apparent that SD is a more dynamic process with greater inherent instability. Knowledge of SA and SD phases and CM/CP dynamics in healthy, normal subjects will permit comparison with patients exhibiting various pathologies. Such comparison should facilitate the development of appropriate intervention strategies.
The memorial pain assessment card. A valid instrument for the evaluation of cancer pain (1987)

Effective evaluation and treatment of cancer pain require valid and independent measurement of pain intensity, pain relief, and psychological distress. The Memorial Pain Assessment Card (MPAC) is a simple instrument designed to provide rapid evaluation of these subjective experiences. On the 8.5 by 11 inch card are printed the eight pain intensity descriptors, and three visual analog scales which measure pain intensity, pain relief, and mood. Experienced patients can complete it in less than 20 seconds. The authors administered the MPAC to 50 hospitalized cancer patients within 48 hours of referral to the Pain Service for inadequate pain control, together with standard measures: The McGill Pain Questionnaire, Profile of Mood States, Hamilton Depression Scale, and Zung Anxiety Scale. Correlational and multiple regression analyses revealed that the MPAC can distinguish pain intensity from pain relief and from general psychological distress, and it can provide multidimensional assessment that is practically equivalent to the full assessment battery. We conclude that the MPAC is valid and effective for clinical use, and recommend it for the assessment of individual patients, and as an outcome measure in clinical trials.
The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. (2005)

Nitric oxide (NO) is a key bioregulatory active molecule in the cardiovascular, immune and nervous systems, synthesized through converting L-arginine to L-citrulline by NO synthase (NOS). Research exploration supports the theory that this molecule appears to be one of the key factors for the disruption of normal brain homeostasis, which causes the development of brain lesions and pathology such as in Alzheimer's disease (AD). Especially the vascular content of NO activity appears to be a major contributor to this pathology before the overexpression of NOS activity in other brain cellullar compartments develop. We theorize that pharmacological intervention using NO donors and/or NO suppressors should delay or minimize brain lesion development and further progression of brain pathology and dementia.
CDC Guidelines on Infection Control (1982)

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Low-Dose Carbon Monoxide Does Not Reduce Vasoconstriction in Isolated Rat Lungs (1996)

Recent studies have demonstrated that nitric oxide (NO) acts as a pulmonary vasodilator when inhaled in low concentrations. Due to the physicochemical similarities between NO and carbon monoxide (CO), it was speculated that low concentrations of CO would have similar effects in the isolated rat lung. The purpose of this study was to determine the role of CO (200 and 1000 ppm) in modulating hypoxia- and angiotensin II (AII)-induced pulmonary vasoconstriction, using isolated salt-perfused lungs of normotensive (CON) or pulmonary hypertensive male rats. Pulmonary hypertensive rats (ALT), induced by simulated altitude exposure (4572 m; 430 mm Hg for 32-48 days), were studied to determine the actions of low-dose CO in a remodeled pulmonary vascular bed. Right ventricular hypertrophy and polycythemia were evident in the ALT rats, suggesting that simulated altitude exposure induced pulmonary hypertension and consequent pulmonary vascular remodeling. CO did not significantly affect pulmonary vascular responses to acute hypoxia (6% CO2, balance N2) in either CON or ALT rats. There were also no significant differences in pulmonary pressor responses to AII injections (0.2 or 0.4 micrograms) in CON or ALT lungs either immediately following or during an acute hypoxia + CO exposure. Therefore, acute low-dose CO exposure (< 1000 ppm) does not appear to attenuate pulmonary vasoconstriction in isolated rat lungs.
UMCC_DLSI: Reinforcing a Ranking Algorithm with Sense Frequencies and Multidimensional Semantic Resources to solve Multilingual Word Sense Disambiguation (2013)

This work introduces a new unsupervised approach to multilingual word sense disambiguation. Its main purpose is to automatically choose the intended sense (meaning) of a word in a particular context for different languages. It does so by selecting the correct Babel synset for the word and the various Wiki Page titles that mention the word. BabelNet contains all the output information that our system needs, in its Babel synset. Through Babel synset, we find all the possible Synsets for the word in WordNet. Using these Synsets, we apply the disambiguation method Ppr+Freq to find what we need. To facilitate the work with WordNet, we use the ISR-WN which offers the integration of different resources to WordNet. Our system, recognized as the best in the competition, obtains results around 69% of Recall.
Epidermal expression of the full‐length extracellular calcium‐sensing receptor is required for normal keratinocyte differentiation (2002)

The importance of the extracellular calcium-sensing receptor (CaR) in the stringent control of extracellular Ca(2+) concentration is well established. However, the presence of CaR in tissues not directly involved in regulating mineral ion homeostasis such as the epidermis suggests a role for CaR in other cellular functions. Although extracellular Ca(2+) regulates the differentiation of epidermal keratinocytes, the role of CaR in this process in the epidermis is not fully understood. In this study we showed using in situ hybridization and immunohistochemistry that CaR is expressed in suprabasal keratinocytes of the mammalian epidermis. We then evaluated the changes in epidermal keratinocyte morphology and differentiation in Casr(-/-) mice lacking the full-length CaR. These mice show increased expression of an alternatively spliced form of CaR which lacks acute Ca(2+)-signaling properties. The absence of the full-length CaR in the epidermis resulted in ultrastructural changes (abnormal keratohyalin granule formation and precocious lamellar body secretion) in the terminally differentiated granular keratinocytes. Furthermore, the expression of both mRNA and protein for the calcium inducible keratinocyte differentiation markers, filaggrin and loricrin, were down-regulated in the epidermis of Casr(-/-) mice, whereas the number of proliferating cells were increased even though the calcium gradient within the epidermis was enhanced. Our results demonstrate that the epidermal expression of the full-length CaR is required for the normal terminal differentiation of keratinocytes.
Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber (2011)

The migration of cells such as leukocytes, tumor cells, and fibroblasts through 3D matrices is critical for regulating homeostasis and immunity and for driving pathogenesis. Interstitial flow through the extracellular matrix, which can substantially increase during inflammation and in the tumor microenvironment, can influence cell migration in multiple ways. Leukocytes and tumor cells are heterogeneous in their migration responses to flow, yet most 3D migration studies use endpoint measurements representing average characteristics. Here we present a robust new microfluidic device for 3D culture with live imaging under well-controlled flow conditions, along with a comparison of analytical methods for describing the migration behavior of heterogeneous cell populations. We then use the model to provide new insight on how interstitial flow affects MDA-MB-231 breast cancer cell invasion, phenomena that are not seen from averaged or endpoint measurements. Specifically, we find that interstitial flow increases the percentage of cells that become migratory, and increases migrational speed in about 20% of the cells. It also increases the migrational persistence of a subpopulation (5-10% of cells) in the positive or negative flow direction. Cells that migrated upstream moved faster but with less directedness, whereas cells that migrated in the direction of flow moved at slower speeds but with higher directedness. These findings demonstrate how fluid flow in the tumor microenvironment can enhance tumor cell invasion by directing a subpopulation of tumor cells in the flow direction; i.e., towards the draining lymphatic vessels, a major route of metastasis.
Multispike train analysis (1977)

Multispike trains are encountered often, either purposely or inadvertently, when one records from neural populations. This paper focuses on techniques for detecting and identifying the spikes in multispike trains. Relatively simple methods are briefly reviewed. Most of these require a high signal-to-noise ratio. A method based on signal detection by template matching, which works well with relativeiy small spikes, is described in detail. Use of this technique is illustrated by an investigation of the biophysical aspects of extracellular recording in sensory cortex. A further application is the analysis of multi-unit records to display relationships between two or three neurons recorded simultaneously.
Measurements of carbon sequestration by long‐term eddy covariance: methods and a critical evaluation of accuracy (1996)

Abstract The turbulent exchanges of CO 2 and water vapour between an aggrading deciduous forest in the north‐eastern United States (Harvard Forest) and the atmosphere were measured from 1990 to 1994 using the eddy covariance technique. We present a detailed description of the methods used and a rigorous evaluation of the precision and accuracy of these measurements. We partition the sources of error into three categories: (1) uniform systematic errors are constant and independent of measurement conditions (2) selective systematic errors result when the accuracy of the exchange measurement varies as a function of the physical environment, and (3) sampling uncertainty results when summing an incomplete data set to calculate long‐term exchange. Analysis of the surface energy budget indicates a uniform systematic error in the turbulent exchange measurements of ‐20 to 0%. A comparison of nocturnal eddy flux with chamber measurements indicates a selective systematic underestimation during calm (friction velocity < 0.17 m s −1 ) nocturnal periods. We describe an approach to correct for this error. The integrated carbon sequestration in 1994 was 2.1 t C ha −1 y −1 with a 90% confidence interval due to sampling uncertainty of ±0.3 t C ha −1 y −1 determined by Monte Carlo simulation. Sampling uncertainty may be reduced by estimating the flux as a function of the physical environment during periods when direct observations are unavailable, and by minimizing the length of intervals without flux data. These analyses lead us to place an overall uncertainty on the annual carbon sequestration in 1994 of ‐0.3 to +0.8 t C ha −1 y −1 .
Variable compliance and geometry regulation of Soft-Bubble grippers with active pressure control (2021)

While compliant grippers have become increasingly commonplace in robot manipulation, finding the right stiffness and geometry for grasping the widest variety of objects remains a key challenge. Adjusting both stiffness and gripper geometry on the fly may provide the versatility needed to manipulate the large range of objects found in domestic environments. We present a system for actively controlling the geometry (inflation level) and compliance of Soft-bubble grippers - air filled, highly compliant parallel gripper fingers incorporating visuotactile sensing. The proposed system enables large, controlled changes in gripper finger geometry and grasp stiffness, as well as simple in-hand manipulation. We also demonstrate, despite these changes, the continued viability of advanced perception capabilities such as dense geometry and shear force measurement - we present a straightforward extension of our previously presented approach for measuring shear induced displacements using the internal imaging sensor and taking into account pressure and geometry changes. We quantify the controlled variation of grasp-free geometry, grasp stiffness and contact patch geometry resulting from pressure regulation and we demonstrate new capabilities for the gripper in the home by grasping in constrained spaces, manipulating tools requiring lower and higher stiffness grasps, as well as contact patch modulation.
Inhibition of Prostaglandin E<sub>2</sub> Production by Anti-inflammatory <i>Hypericum perforatum</i> Extracts and Constituents in RAW264.7 Mouse Macrophage Cells (2007)

Hypericum perforatum (Hp) is commonly known for its antiviral, antidepressant, and cytotoxic properties, but traditionally Hp was also used to treat inflammation. In this study, the anti-inflammatory activity and cytotoxicity of different Hp extractions and accessions and constituents present within Hp extracts were characterized. In contrast to the antiviral activity of Hp, the anti-inflammatory activity observed with all Hp extracts was light-independent. When pure constituents were tested, the flavonoids, amentoflavone, hyperforin, and light-activated pseudohypericin, displayed anti-inflammatory activity, albeit at concentrations generally higher than the amount present in the Hp extracts. Constituents that were present in the Hp extracts at concentrations that inhibited the production of prostaglandin E(2) (PGE(2)) were pseudohypericin and hyperforin, suggesting that they are the primary anti-inflammatory constituents along with the flavonoids, and perhaps the interactions of these constituents and other unidentified compounds are important for the anti-inflammatory activity of the Hp extracts.
Optical Damage Limits to Pulse Energy From Fibers (2009)

The irradiances or fluences encountered in pulsed fiber lasers and amplifiers are sometimes high enough to destroy the fiber. The ultimate limit is set by the intrinsic damage threshold irradiance of doped silica. Other nonlinear processes such as self-focusing and stimulated Brillouin scattering are also important. We present here the results of our measurements of the damage threshold, and of our analysis of how self-focusing and Brillouin scattering influence the power limit.
Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration (2000)

Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide range of cancer cells and plays important roles in cancer progression and metastasis. Recently, the intracellular function of TF has been revealed to be involved in cancer invasion, independent of the blood coagulation pathway. To evaluate the clinical significance of TF expression, we performed an enzyme-linked immunosorbent assay (ELISA) in the plasma of 67 breast cancer patients and immunohistochemistry in 213 breast cancer tissues. In the ELISA study, we showed an up-regulation of plasma TF concentration in breast cancer patients compared with normal controls. Immunohistochemistry demonstrated that TF was expressed in tumour cells and stromal cells and tumour TF expression closely correlated with stromal TF expression (P = 0.0005). The concentration of plasma TF was associated with tissue TF expression in both tumour and stroma. The multivariate analysis demonstrated that tumour TF expression was an independent prognostic indicator for overall survival (P = 0.0452). Our data show that plasma TF concentration reflects tissue TF expression and tumour TF expression can provide some predictive value for prognosis and distant metastasis, which indicates the importance of TF function in tumour progression.
Chromosomal Location of Human T-Cell Receptor Gene T <sub>i</sub> β (1984)

A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.
Mapping and comparing bacterial microbiota in the sinonasal cavity of healthy, allergic rhinitis, and chronic rhinosinusitis subjects (2017)

This study presents the sinonasal microbiome profile in one of the larger populations of non-CRS and CRS subjects, and is the first office-based cohort in the literature. In contrast to healthy, AR, and CRSwNP subjects, CRSsNP MM samples exhibited decreased microbiome diversity and anaerobic enrichment. CRSsNP MM samples had reduced diversity compared to same-subject IM samples, a novel finding.
11,12-Epoxyeicosatrienoic Acid Stimulates Endogenous Mono-ADP-Ribosylation in Bovine Coronary Arterial Smooth Muscle (1999)

The role of endogenous ADP-ribosylation in mediating the activation of the Ca(2+)-activated K(+) channels was determined in bovine coronary arteries. Endogenous ADP-ribosylation was examined by incubating coronary arterial homogenates or lysates of cultured coronary arterial smooth muscle cells with [adenylate-(32)P]NAD. Four (32)P-labeled proteins were observed at 51, 52, 80, and 124 kDa in the homogenates and lysates. This reaction was enhanced by the addition of 11,12-epoxyeicosatrienoic acid (11,12-EET), a cytochrome P450-derived eicosanoid, and GTP to the incubation. By Western blot analysis, 42- and 70-kDa proteins were recognized by specific antibodies against ADP-ribosyltransferase in the coronary arterial homogenates and smooth muscle cell lysate but not in the lysate of endothelial cells. The 52-kDa acceptor protein of endogenous ADP-ribosylation comigrated with a protein ADP-ribosylated by cholera toxin and was recognized and immunoprecipitated by an anti-G(S)alpha antibody. These results suggest that G(S)alpha is one of several acceptors of the ADP-ribose moiety. As shown by the patch-clamp technique, 11,12-EET stimulated the activation of the K(+) channels in the smooth muscle cells, and this activation was completely blocked by novobiocin, vitamin K(1), 3-aminobenzamide, and m-iodobenzylguanidine, inhibitors of endogenous mono-ADP-ribosyltransferases. We conclude that endogenous mono-ADP-ribosyltransferases are present in smooth muscle from bovine coronary arteries. These enzymes transfer ADP-ribose to the cellular proteins such as G(S)alpha and may mediate intracellular signal transduction in coronary vascular smooth muscle. In the coronary circulation, the ADP-ribosylation signaling pathway may play an important role in mediating the activation of the K(+) channels induced by 11,12-EET.
Quantitative structure-activity relationships in acaricidal 4H-1,3,4-oxadiazin-5(6H)-ones (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative structure-activity relationships in acaricidal 4H-1,3,4-oxadiazin-5(6H)-onesMark A. Dekeyser, David M. Borth, Richard C. Moore, and Anupama MishraCite this: J. Agric. Food Chem. 1991, 39, 2, 374–379Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://doi.org/10.1021/jf00002a030RIGHTS & PERMISSIONSArticle Views161Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (713 KB) Get e-Alerts Get e-Alerts