gebhart/patrepeval huggingface dataset:
Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a (2011)

The sarcoplasmic reticulum calcium ATPase (SERCA) plays a central role in regulating intracellular Ca(2+) homeostasis and myocardial contractility. Several studies show that improving Ca(2+) handling in hypertrophied rodent hearts by increasing SERCA activity results in enhanced contractile function. This suggests that SERCA is a potential target for gene therapy in cardiac hypertrophy and failure. However, it raises the issue of increased energy cost resulting from a higher ATPase activity. In this study, we determined whether SERCA overexpression alters the energy cost of increasing myocardial contraction in mouse hearts with pressure-overload hypertrophy using (31)P NMR spectroscopy. We isolated and perfused mouse hearts from wild-type (WT) and transgenic (TG) mice overexpressing the cardiac isoform of SERCA (SERCA2a) 8 weeks after ascending aortic constriction (left ventricular hypertrophy (LVH)) or sham operation. We found that overexpressing SERCA2a enhances myocardial contraction and relaxation in normal mouse hearts during inotropic stimulation with isoproterenol. Energy consumption was proportionate to the increase in contractile function. Thus, increasing SERCA2a expression in the normal heart allows an enhanced inotropic response with no compromise in energy supply and demand. However, this advantage was not sustained in LVH hearts in which the energetic status was compromised. Although the overexpression of SERCA2a prevented the down-regulation of SERCA protein in LVH hearts, TG-LVH hearts showed no increase in inotropic response when compared with WT-LVH hearts. Our results suggest that energy supply may be a limiting factor for the benefit of SERCA overexpression in hypertrophied hearts. Thus, strategies combining energetic support with increasing SERCA activity may improve the therapeutic effectiveness for heart failure.
Deep Learning for Network Traffic Monitoring and Analysis (NTMA): A Survey (2021)

Modern communication systems and networks, e.g., Internet of Things (IoT) and cellular networks, generate a massive and heterogeneous amount of traffic data. In such networks, the traditional network management techniques for monitoring and data analytics face some challenges and issues, e.g., accuracy, and effective processing of big data in a real-time fashion. Moreover, the pattern of network traffic, especially in cellular networks, shows very complex behavior because of various factors, such as device mobility and network heterogeneity. Deep learning has been efficiently employed to facilitate analytics and knowledge discovery in big data systems to recognize hidden and complex patterns. Motivated by these successes, researchers in the field of networking apply deep learning models for Network Traffic Monitoring and Analysis (NTMA) applications, e.g., traffic classification and prediction. This paper provides a comprehensive review on applications of deep learning in NTMA. We first provide fundamental background relevant to our review. Then, we give an insight into the confluence of deep learning and NTMA, and review deep learning techniques proposed for NTMA applications. Finally, we discuss key challenges, open issues, and future research directions for using deep learning in NTMA applications.
The relationship of interacting immunological components in dengue pathogenesis (2009)

The World Health Organization (WHO) estimates that there are over 50 million cases of dengue fever reported annually and approximately 2.5 billion people are at risk. Mild dengue fever presents with headache, fever, rash, myalgia, osteogenic pain, and lethargy. Severe disease can manifest as dengue shock syndrome (DSS) or dengue hemorrhagic fever (DHF). Symptoms of DSS/DHF are leukopenia, low blood volume and pressure encephalitis, cold and sweaty skin, gastrointestinal bleeding, and spontaneous bleeding from gums and nose. Currently, there are no therapeutics available beyond supportive care and untreated complicated dengue fever can have a 50% mortality rate. According to WHO DSS/DHF is the leading cause of childhood mortality in some Asian countries. Dendritic cells are professional antigen presenting cells that are primary targets in a dengue infection. Dengue binds to Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN). DC-SIGN has a high affinity for ICAM3 which is expressed in activating T-cells. Previous studies have demonstrated an altered T-cell phenotype expressed in dengue infected patients that could be potentially mediated by dengue-infected DCs.Dengue is enhanced by three interacting components of the immune system. Dengue begins by infecting dendritic cells which in immature dendritic cells is mediated by DC-SIGN. In mature dendritic cells, antibodies can enhance dengue infection via Fc receptors. Downstream of dendritic cells T-cells become activated and generate the very cytokines implicated in vascular leak and shock in addition to activating effector cells. Both the virus and the antibodies are involved in release of complement and anaphylatoxins which can cause or exacerbate DHF/DSS. These systems are inextricable and strongly associated with dengue pathogenesis.
<i>Q</i>-SWITCHED LASER WITH CONTROLLABLE PULSE LENGTH (1971)

Experimental results of a recently proposed technique for obtaining Q-switched laser pulses of controllable length are presented. A lithium iodate doubling crystal inside the cavity of a Nd: YAG laser running at 0.946 μ is used to provide both output coupling and an easily adjustable, nonlinear loss mechanism. Controllable pulse lengths in the range of 200 nsec to 1 μ at 0.473 μ have been achieved at nominally constant energy.
O ensino-aprendizagem de espanhol na terceira idade (2015)

The extension project UNATI - Open University for Senior Citizens- aims together with the students of campus UNESP/Assis to offer the elderly community from the city of Assis courses that provide the inclusion of this audience in the social coexistence. In this way, the course of Spanish language, ministered by two students of Letters course, expands the cultural manifestations that this language cover and highlight the importance of learning a foreign language. After all, the knowledge of a language enriches and contributes to the construction of the personal knowledge and it favors the elderly to understand new values under a linguistic-cultural perspective. At the same time, are concretized acquaintanceship and stories.
<b>The Absolute Configuration of Pentadiendioic Acid</b> (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Absolute Configuration of Pentadiendioic AcidWilliam C. AgostaCite this: J. Am. Chem. Soc. 1962, 84, 1, 110–111Publication Date (Print):January 1, 1962Publication History Published online1 May 2002Published inissue 1 January 1962https://pubs.acs.org/doi/10.1021/ja00860a026https://doi.org/10.1021/ja00860a026research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Distributed Parallel Processing Based on Master/Worker Model in Heterogeneous Computing Environment (2012)

Due to the complexity and varying requirements of the applications to utilize large-scale computing resources, there are several issues such as aggregating heterogeneous computing resources, easy-touse programming model and fault-tolerant mechanism that need to be addressed. This paper presents a general distributed parallel processing architecture based on master/worker model, and it can aggregate various heterogeneous computing resources without coupling to any specific hardware and architecture. On this basis, we implement a general framework based on TSpaces for large-scale distributed computation of problems that feature coarse-grained parallelization. Furthermore, we present a dynamic managing mechanism of voluntary computing resources in unreliable environment. The experiment results indicate that our implementation has preferable performance, and can achieve high availability and reliability in the environment of dynamic changing resources and unreliable loose-coupling networks.
Terahertz parametric generation photonic band gap structure with negligible structural dispersion in the optical range (2006)

We present a photonic band gap (PBG) structure (or nonlinear photonic crystal) design for terahertz (THz) wave parametric generation, whose component materials have a small refractive index difference in the near infrared and a large index difference for THz waves. The structural dispersion of such a PBG structure is strong in the THz range but negligible in the optical range. The former allows the phase-matched pump wavelength to be placed in the near infrared to eliminate two-photon absorption of the pump and signal beams. The latter leads to a crystal layer fabrication tolerances of a few micrometers and traditional polishing methods are suitable for device fabrication. The added design flexibility also allows the use of the most efficient crystal orientations.
1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture (1972)

1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated 45 Ca from fetal rat bones in organ culture, at concentrations of 10 -10 to 10 -8 M . The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.
ChemInform Abstract: Hydroxyiminoisoquinolin‐3(2H)‐ones. Part 5. Synthesis of 4‐Amino‐1,2,3,4‐tetrahydroisoquinolines. (1987)

Abstract Reductive acylation of the iminodihydroisoquinolinones (I) yields theacetylamino compounds (III), which are converted to the aminotetrahydroisoquinolines (V).
Müllerʼs Superior Tarsal Muscle: Anatomy, Physiology, and Clinical Significance (1985)

Müller's superior tarsal muscle has been extensively studied by anatomists and physiologists but has been largely ignored by surgeons. This muscle is considered from the standpoint of both gross and finer anatomy. Concepts regarding the uncertain course of its sympathetic nerve supply fibers are reviewed, and "semi-conclusions" are given. The physiology of the muscle, both normal and pathological, is considered in view of both accepted and controversial concepts. Methods of weakening an overactive Müller's muscle medically and surgically are discussed. Some methods that have attempted to utilize the lid-elevating power of Müller's muscle are described, and the muscle's potential in this regard is considered. This small muscle is deserving of more appreciation and of a higher surgical status than it has received in the past.
Application of Visual Servoing to an X-ray Based Welding Inspection Robot (2005)

The paper presents a control system structure for an X-ray based welding inspection and image recording, and studies a new method to realize the synchronous movement between the inner and outer robots. The paper provides a new design to sense the relative movement of robots and utilizes it to synchronize the movement of dual robots. Based on the theory of image-based visual servo control, the paper studies its application to the welding scam tracking and cooperation control of dual robot, and implements the control algorithms. A time delay and white noises are introduced to simulate the lag due to image feature recognition and the mechanical vibration in the system. The simulation results show that the outer robot tracks the movement of inner robot very well. The experiments of the visual servo control algorithms are realized on the welding inspection and image recording system.
Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant (2018)

Patients with high-grade serous ovarian carcinoma (HGSC) exhibit poor 5-year survival rates, which may be significantly improved by early-stage detection. The U.S. Food and Drug Administration-approved biomarkers for HGSC-CA-125 (cancer antigen 125) and HE4 (human epididymis protein 4)-do not generally appear at detectable levels in the serum until advanced stages of the disease. An implantable device placed proximal to disease sites, such as in or near the fallopian tube, ovary, uterine cavity, or peritoneal cavity, may constitute a feasible strategy to improve detection of HGSC. We engineered a prototype optical sensor composed of an antibody-functionalized carbon nanotube complex, which responds quantitatively to HE4 via modulation of the nanotube optical bandgap. The complexes measured HE4 with nanomolar sensitivity to differentiate disease from benign patient biofluids. The sensors were implanted into four models of ovarian cancer, within a semipermeable membrane, enabling the optical detection of HE4 within the live animals. We present the first in vivo optical nanosensor capable of noninvasive cancer biomarker detection in orthotopic models of disease.
An improved allele-specific PCR primer design method for SNP marker analysis and its application (2012)

The method provided in this study can generate primers more effectively for every SNP site compared to other AS-PCR primer design methods. The high allele-specific efficiency of the SNP primer allows the feasibility for low- to moderate- throughput SNP analyses and is much suitable for gene mapping, map-based cloning, and marker-assisted selection in crops.
Pulsed holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation of fibrocartilage and articular cartilage (1990)

A new, near-infrared, pulsed holmium laser (wavelength, 2.1 microns; pulse duration, 400 microseconds) was used to ablate bovine articular cartilage and meniscal fibrocartilage. Microscopic examination revealed zones of thermal damage extending 550 microns from ablation sites. Ablation rates were measured with a mass loss technique. Above threshold, mass removal rates were proportional to laser radiant exposure. Threshold radiant exposure for ablation was 50 J/cm2 for articular cartilage and 11 J/cm2 for meniscal fibrocartilage. Because the holmium laser can precisely and rapidly resect cartilaginous tissues with only moderate necrosis, function in a saline environment in direct contact with tissue, and be transmitted through conventional optical fibers, it has the potential to become a useful tool for the precise arthroscopic removal of intraarticular tissue.
CULTURE OF FETAL ERYTHROID PROGENITOR CELLS FROM MATERNAL BLOOD FOR NON-INVASIVE PRENATAL GENETIC DIAGNOSIS (1996)

Fetal committed erythroid progenitors CFU-E and M-BFU-E released into the maternal circulation during pregnancy are ideal candidates for in vitro proliferation since their lifespan is short and they can form colonies of 100-1000 cells in a semi-solid medium. In order to propagate these cells with a high rate of purity, a strategy was devised based on their prior enrichment with biotin-labelled human erythropoietin ligand and magnetic sorting before culturing in a suitable medium. Eight euploid pregnancies investigated in order to address this issue produced fetal clones in cultures with 18 per cent purity as assessed by polymerase chain reaction (PCR) analysis for Y-specific sequences, immunocytochemical staining for fetal gamma-globin, and fluorescence in situ hybridization (FISH) study. The CFU-E-type colony was the most represented progenitor, followed by M-BFU-E, and only occasionally was the detection of CFU-GEMM recorded. The retrospective diagnosis of two cases of fetal Down's syndrome by culturing fetal cells from maternal blood was accomplished for the first time. FISH analysis disclosed a strong presence of fetal trisomic cells (70 per cent and 40 per cent in the two cases). This strong presence would suggest a preferential leakage into maternal blood. The overall results of this study demonstrate that fetal cells can be cultured in vitro with reliable reproducibility, thus making the prospect of a non-invasive prenatal genetic diagnosis realistic.
Should thiazide diuretics be first-line therapy for high-risk hypertensive patients? (2004)

VOL 50: MAY • MAI 2004 d Canadian Family Physician • Le Medecin de famille canadien 713 ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. Th e Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981-97.
Conversion of Furfuryl Alcohol into Ethyl Levulinate using Solid Acid Catalysts (2009)

Furfural, a potential coproduct of levulinic acid, can be converted into levulinic acid via hydrogenation to furfuryl alcohol and subsequent ethanolysis to ethyl levulinate. The ethanolysis reaction is known to proceed in the presence of H(2)SO(4). We show here that several strongly acidic resins are comparably effective catalysts for this reaction. Optimal performance is achieved by balancing the number of acid sites with their accessibility in the resin. Acidic zeolites such as H-ZSM-5 also catalyze this reaction, although with a lower activity and a higher co-production of diethyl ether.
Swine mycoplasmoses (1996)

Mycoplasma hyopneumoniae is the primary agent of enzootic pneumonia in pigs. The lung lesions, generally observed in young pigs, are characterised by a hyperplasia of the epithelial cells and an increased perivascular and peribronchiolar accumulation of mononuclear cells. Following M. hyopneumoniae infection, immune reactions are observed and resistance is induced in pigs. Laboratory diagnosis is generally performed by an immunofluorescent test and by enzyme-linked immunosorbent assay. Antibiotics are useful but the development of resistance has been described. Vaccination seems to be an effective method of controlling the disease. M. hyorhinis, generally transmitted by sows to piglets through nasal secretions, exists in a high percentage in the respiratory tract of healthy pigs. But some strains can induce serofibrinous to fibrinopurulent polyserositis and arthritis. M. hyorhinis is isolated from acute and subacute phase lesions and serum antibodies are detectable. M. hyosynoviae has a special affinity for joint tissue and may cause arthritic disease, leading to economic losses. This mycoplasma is generally located in the tonsils. Piglets are infected by sows after four to six weeks of life. Evidence of disease occurs in animals of between 30 to 40 kg and 100 kg, and bursae and joints are affected. A non-suppurative viscous fluid of a serofibrinous/serosanguineous nature is reported. In chronic cases, the synovial membrane is affected. M. hyosynoviae is isolated from the joints and pharyngeal/tonsillar samples and can induce antibodies in blood and joint fluid. Predisposing factors play an important role. M. flocculare is widely distributed in swine, in normal and pneumonic lungs and in nasal cavities, but no pathogenic capability has been described. There is great interest in this mycoplasma because of the great similarity to M. hyopneumoniae.
Local Anesthetics. I. β-Monoalkylaminoethyl Esters of Alkoxybenzoic Acids<sup>1</sup> (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLocal Anesthetics. I. β-Monoalkylaminoethyl Esters of Alkoxybenzoic Acids1J. Stanton Pierce, J. M. Salsbury, and J. M. FredericksenCite this: J. Am. Chem. Soc. 1942, 64, 7, 1691–1694Publication Date (Print):July 1, 1942Publication History Published online1 May 2002Published inissue 1 July 1942https://pubs.acs.org/doi/10.1021/ja01259a062https://doi.org/10.1021/ja01259a062research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lessons from Mouse Mutants of Epithelial Sodium Channel and Its Regulatory Proteins (2005)

The use of gene-modified mouse models allows the experimental in vivo analysis of specific gene defects at the level of target cells. With respect to the epithelial sodium channel and some of its regulatory proteins, gene-modified models that control gene defects in a time- and tissue-dependent conditional or constitutive manner have been generated. The combination of molecular and physiologic approaches in these mouse models increases the understanding of the complex regulation and the cell signaling cascades involved in Na(+) transport in target cells and may ultimately provide new insights into the pathophysiology of renal Na(+) retention and BP regulation. This review summarizes and discusses the gene-targeting approaches that have been applied to the epithelial sodium channel and its regulatory proteins.