gebhart/patrepeval huggingface dataset:
Development of sanofi pasteur tetravalent dengue vaccine (2010)

The Sanofi Pasteur tetravalent dengue vaccine candidate is composed of 4 recombinant live attenuated vaccines based on a yellow fever vaccine 17D (YFV 17D) backbone, each expressing the prM and envelope genes of one of the four dengue virus serotypes. Pre-clinical studies have demonstrated that the TV dengue vaccine is genetically and phenotypically stable, non-hepatotropic, less neurovirulent than YFV 17D and does not infect mosquitoes by the oral route. In vitro and in vivo preclinical studies also showed that the TV dengue vaccine induced controlled stimulation in human dendritic cells and significant immune responses in monkeys. TV dengue vaccine reactogenicity, viraemia induction and antibody responses were investigated in three Phase I trials in the USA, the Philippines and Mexico, in a two or three-dose regimen over a 12 month period. Results showed that the majority of adverse events were mild to moderate and transient in nature. Viraemia was transient and low, and was not increased after initial dengue TV administration, even in the case of incomplete responses. ϕSeropositivity [≥10 in a PRNT 50 assay] was 100% for all four serotypes in flavivirus-naive adults injected with 3 doses of TV dengue vaccine in the USA. Similarly, seropositivity was 88-100% following three administrations in flavivirus-naive Mexican children aged 2-5 years. Furthermore, the proportion of seropositive subjects increased with each dengue TV injection in the Philippines where baseline flavivirus immunity was high. Responses were also monitored at the cellular level in humans, and their level and nature were in good agreement with the observed safety and the immunogenicity of the vaccine. Finally, the challenges inherent to the development of such TV dengue vaccines will also be discussed in the last part of this review. In conclusion, preclinical and clinical results support the favorable immunogenicity and short-term safety of the dengue TV vaccine. An extensive clinical development program for dengue TV is underway including completion of the enrollment of 4,000 4-11 years old children in an efficacy trial in Thailand, in an area of high dengue incidence. Assuming continued successful outcomes, initial submissions to regulatory authorities are envisaged within a 5-year period.
Kinetic study of lipase catalyzed esterification reactions in water‐in‐oil microemulsions (1993)

The kinetics of the esterification of lauric acid by (-)menthol, catalyzed by Penicillium simplicissimum lipase, was studied in water/bis-(2-ethylhexyl)sulfosuccinate sodium salt (AOT)/isooctane microemulsions. Due to their low water content, microemulsions assist in reversing the direction of lipase activity, favoring synthetic reactions. The kinetics of this synthesis follows a Ping-Pong Bi--Bi mechanism. The values of all apparent kinetic parameters were determined. The theoretical model for the expression of enzymic activity in reverse micelles, proposed by Verhaert et al. (Verhaert, R., Hilhorst, R., Vermüe, M., Schaafsma, T. J., Veeger, C. 1990. Eur. J. Biochem. 187: 59-72) was extended to express the lipase activity in an esterification reaction involving two hydrophobic substrates in microemulsion systems. The model takes into account the partitioning of the substrates between the various phases and allows the calculation of the intrinsic kinetic constants. The experimental results showing the dependence of the initial velocity on the hydration ratio, W(o) = [H(2)O]/[AOT], of the reverse micelles, were in accordance with the theoretically predicted pattern.
A Feasibility Study of an In-the-Wild Experimental Public Access WiFi Network (2014)

Universal Internet access has become critical to modern life, leading to many explorations of approaches to increase its availability. In this paper we report on a study of one such approach, PAWS, that seeks to understand the technical and social constraints of providing Internet access, free at the point of use, by sharing existing broadband subscribers' connections. We elaborate the technical and social context of our deployment, a deprived neighbourhood in a medium-sized British city, and discuss the constraints on and resulting architecture of this system, including the authentication and security mechanisms necessary for a service of this kind. We then report on the use of our deployment over a period of seven months from July 2013 to February 2014, including analyses of the performance and usage of the network. Our data show that PAWS is socially and technically feasible and has the potential to provide Internet access economically to many who are currently digitally disenfranchised. However, doing so requires overcoming numerous challenges, both technical and social.
Perceived discrimination, internalized stigma and well-being in people with mental illness (2016)

La investigacion llevada a cabo en esta tesis tuvo por objeto en primer lugar determinar la relacion entre la percepcion de estigmatizacion y la internalizacion del estigma, y el efecto de estas sobre el bienestar subjetivo de las personas con enfermedad mental, asi como con su satisfaccion con la vida y su bienestar psicologico, entre otras variables. La metodologia empleada fueron estudios transversales con usuarios de distintos centros de rehabilitacion de la red publica de atencion a las personas con enfermedad mental. Los resultados de los dos estudios indican que la discriminacion individual sutil predice una mayor internalizacion del estigma, y esta a su vez predice un menor bienestar psicologico y subjetivo. Los datos tambien son coherentes con la mediacion del bienestar psicologico entre el estigma internalizado y el bienestar subjetivo. No obstante, al analizar los efectos de los distintos componentes del estigma internalizado por separado, se observo que la alienacion era el unico que predecia significativamente ambos tipos de bienestar. Estos hallazgos podrian orientar el diseno de intervenciones que ayuden a los usuarios de los servicios de atencion a las personas con enfermedad mental a combatir la estigmatizacion y a afrontarla de forma que afecte lo menos posible a su bienestar.
Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype. (1994)

GH-3 is an established cell line which, for the production of both PRL and GH, may be related to the bipotential somatomammotroph from which both somatotroph and mammotroph cells derive. In the present study we first report that GH-3 cells express both the gp140trk and the gp75 components of the nerve growth factor (NGF) receptor and that NGF dictates a nonneuronal type of differentiation of this cell line of ectodermal origin. After exposure to NGF, GH-3 cells markedly decreased their proliferation rate. This effect, which was maximal (50% inhibition) 3 days after beginning the treatment and was maintained during the following days of exposure, was paralleled by a change in the hormone production. The secretion of PRL was increased 6-fold, but that of GH was remarkably inhibited. Moreover, GH-3 cells expressed the mammotroph-specific D-2 receptor protein in response to NGF, as shown by binding with the D-2 receptor ligand N-(p-aminophenetyl)spiperone coupled to fluorescein. The present data thus show that NGF induces the differentiation of GH-3 cells into one of their physiological counterparts, the mammotroph cell, and together with the finding that NGF receptors are expressed in the anterior pituitary suggest a physiological role for the neurotrophic factor in pituitary ontogenesis.
Learning K-way D-dimensional Discrete Codes for Compact Embedding Representations (2018)

Conventional embedding methods directly associate each symbol with a continuous embedding vector, which is equivalent to applying a linear transformation based on a "one-hot" encoding of the discrete symbols. Despite its simplicity, such approach yields the number of parameters that grows linearly with the vocabulary size and can lead to overfitting. In this work, we propose a much more compact K-way D-dimensional discrete encoding scheme to replace the "one-hot" encoding. In the proposed "KD encoding", each symbol is represented by a $D$-dimensional code with a cardinality of $K$, and the final symbol embedding vector is generated by composing the code embedding vectors. To end-to-end learn semantically meaningful codes, we derive a relaxed discrete optimization approach based on stochastic gradient descent, which can be generally applied to any differentiable computational graph with an embedding layer. In our experiments with various applications from natural language processing to graph convolutional networks, the total size of the embedding layer can be reduced up to 98\% while achieving similar or better performance.
Threat assessment of malicious code and external attacks (1992)

of Standards and Technology has been tasked with providing an assess- ment of the threats associated with commercial
Inhibitors of cholera toxin-induced adenosine diphosphate ribosylation of membrane-associated proteins block stem cell differentiation (1985)

Two potent inhibitors of mono-adenosine diphosphate (ADP) ribosylation have recently been described and characterized, named p-methoxylbenzylaminodecamethylene guanidine sulfate (MBAMG) and benzylaminododecylguanine hydrochloride (BADGH). We have used these agents to investigate the role of ADP ribosylation in hematopoiesis using long-term marrow cultures. The addition of MBAMG (10(-6) mol/L) or BADGH (5 X 10(-4) mol/L) led to both an inhibition of mature cell production and the development of colony-stimulating factor (CSF-1)-responsive GM-CFC, but had no effect upon spleen colony-forming units (CFU-S) or on progenitor cells which respond to the multilineage stimulating factor present in WEHI-3B cell-conditioned medium. These data indicate that these inhibitors of mono-ADP ribosylation can block the commitment and/or differentiation of stem cells and infers that ADP ribosylation may be of some importance in the hematopoietic process.
A 0.01–26 GHz single-chip SiGe reflectometer for two-port vector network analyzers (2017)

This paper presents a single-chip 0.01-26 GHz reflectometer for two-port vector network analyzers (VNA). The reflectometer consists of a bridge coupler integrated together with two wideband heterodyne receivers. For wideband operation, a resistive bridge coupler is used with a directivity of 33 dB up to 26 GHz. Also, a high-linearity receiver channel is designed so as to accommodate 10 dBm of RF input power to the reflectometer. The SiGe chip is 1.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 640 mW from a 3.3 V supply. The dynamic range of the reflectometer chip is 127±2 dB at 0.01-26 GHz with an IF resolution bandwidth (RBW) of 10 Hz. The chip is placed on a printed circuit board (PCB), and RF, LO and DC bias are connecterized. Measurements of several device-under-test units (DUTs) with a two-port 0.01-26 GHz VNA composed of two reflectometer chips shows excellent agreement with a commercial VNA, with a magnitude and phase difference of <; 0.2 dB and <; 2° respectively for Su. Two-port measurements also show an 821 dynamic range of 80 dB, limited by the measurement setup and not by the chip. To our best knowledge, this is the first demonstration of a VNA operating from 10 MHz to mm-wave frequencies with the capability of measuring -80 dB of S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> as well as minimal magnitude and phase difference compared to state-of-the-art VNA measurements.
Potentiometric and Spectrophotometric Study of Calcium and Alizarin Red S Complexation. (1992)

Equilibria in the system H+, Ca2+ and Alizarin Red S have been studied by means of potentiometric (glass electrode) and spectrophotometric measurements in a 0.1 M NaCl medium at 25-degrees-C. Calci ...
The formation of a p–n junction in a polymer electrolyte top-gated bilayer graphene transistor (2009)

We show simultaneous p- and n-type carrier injection in a bilayer graphene channel by varying the longitudinal bias across the channel and the top-gate voltage. The top gate is applied electrochemically using solid polymer electrolyte and the gate capacitance is measured to be 1.5 microF cm(-2), a value about 125 times higher than the conventional SiO(2) back-gate capacitance. Unlike the single-layer graphene, the drain-source current does not saturate on varying the drain-source bias voltage. The energy gap opened between the valence and conduction bands using top- and back-gate geometry is estimated.
Human mitochondrial propionyl-CoA carboxylase: localization of the N-terminus of the pro- and mature α chains in the deduced primary sequence of a full-length cDNA (1989)

Propionyl-CoA carboxylase [E.C.6.4.1.3] is a mitochondrial enzyme consisting of a and P polypeptides. Inherited deficiency of the enzyme activity leads to propionicacidemia. To further investigate the mutations involved in this metabolic disorder, we have previously cloned partial cDNAs to both subunits (1). We now report a full-length, 2478 nucleolide cDNA (pPCCA32) coding for the a , biotin-containing polypeptide. It contains a 5'-untranslated sequence of 48 nucleotides, an open reading frame of 2106 nucleotides coding for a 702 amino acid pre-a polypeptide with the biotin-binding site at residue 668 (bold in figure) and a 3'-untranslated sequence of 246 nucleotides with the consensus polyadenylation AATAAA (underlined) upstream of a poly(A) tail. A match of twenty-eight amino acids (underlined) with the N-terminal amino acid sequence determined from the mature a polypeptide of purified human liver enzyme, separated from the |$ polypeptide by HPLC , was found in the deduced sequence of the cDNA. Two methionine residues (in bold) are located in the putative mitochondrial leader sequence of 26 amino acids. As typical of such sequences, this region is hydrophobic and arginine rich.
SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling‐mediated tumorigenesis by enhancing β‐catenin biosynthesis (2013)

Wnt/β-catenin signalling is widely implicated in embryogenesis, tissue homeostasis and tumorigenesis. The key event in Wnt signalling activation is β-catenin accumulation, which is controlled by both its production and degradation. However, much more emphasis has been placed on the understanding of its degradation. Here, we show that the synthesis of β-catenin protein, which requires a group of serine/arginine-rich splicing factors (SRSF), also contributes to its tumorigenic activity. Overexpression of SRSF1 and SRSF9 promote β-catenin accumulation via the recruitment of β-catenin mRNA and by enhancing its translation in an mTOR-dependent manner. We further demonstrate that, like SRSF1, SRSF9 is also an oncogene, and is frequently overexpressed in multiple types of human tumours. Finally, our results suggest that promoting degradation and blocking production of β-catenin synergistically reduce β-catenin levels under pathological conditions and that a combinational therapy could be a promising approach for the treatment of cancer patients.
Spectroelectrochemistry of Nanostructured NiO (2001)

Transparent nanostructured NiO electrodes have been prepared by heating Ni(OH)2 sol−gel films at a temperature of 300−320 °C. Nanostructured NiO (bunsenite) behaves as a p-type semiconductor and has an indirect band gap of 3.55 eV. It shows a strong anodic electrochromic effect, as it changes color from transparent to brown-black upon application of positive potentials. This effect is caused by oxidation of Ni atoms located at the NiO/electrolyte interface. Electrochemical oxidation reactions are highly reversible in both aqueous and nonaqueous electrolytes. In aqueous electrolyte, the half-potentials show a Nernstian pH dependence, whereas in nonaqueous electrolytes, the type of cation present determines the shape and position of the cyclic voltammogram.
Fluoxetine Pharmacokinetics in Pediatric Patients (2002)

The objective of this study was to evaluate the pharmacokinetic profile of fluoxetine (FLX) and its major metabolite, norfluoxetine (NORFLX), in children and adolescent patients undergoing psychiatric treatment. Twenty-one pediatric subjects--10 children (6-12 years) and 11 adolescents (13-18 years)--were administered 20 mg FLX for 60 days, with sparse blood samples taken throughout the open-label study. Subjects contributed 168 plasma concentrations. Pharmacokinetic parameters were estimated using a mixed effects nonlinear model. Mean steady-state FLX and NORFLX of 127 ng/mL and 151 ng/mL, respectively, were achieved in children and adolescents after 4 weeks of treatment, with high between-patient variability. FLX was 2-fold higher and NORFLX was 1.7-fold higher in children relative to adolescents; however, when normalized to body weight, FLX and NORFLX were similar for both age groups. Age, body weight, body mass index, and body surface area, modeled independently as continuous variables, significantly improved the population pharmacokinetic model when evaluated as patient factors. Body weight was the covariate retained in the final model. In conclusion, children have 2-fold higher FLX and NORFLX relative to adolescents that appear to be related to indices of body size. The accumulation profile and steady-state concentrations in adolescents appear similar to those in adults.
Attitude orientation of spin-stabilized space vehicles Patent (1965)

Attitude orientation control of spin stabilized final stage space vehicles, using horizon scanners
Fluorescence turn-on probe for homocysteine and cysteine in water (2008)

A simple fluorescent probe based on an ortho-hydroxy aldehyde-functionalized coumarin showed selective responses to homocysteine and cysteine by fluorescence turn-on.
Crítica al tema 1 del programa de Psicología Médica II (2005)

<p align="justify"><span style="font-family: Arial,Helvetica,sans-serif; font-size: small;">Para comenzar el análisis de la asignatura Psicología Médica II, se hace necesario explicar que esta asignatura forma parte de la disciplina Psicología Médica, que se imparte en los semestres 4to. y 5to. de la Carrera de Medicina, en el curso regular diurno. La Psicología, como ciencia aplicada a la salud del Hombre se estudia en todas las carreras de las Ciencias Médicas.</span> <p align="justify"><span style="font-family: Arial,Helvetica,sans-serif; font-size: small;">En Medicina, desde el 1er. año, durante el primer semestre, en este caso vinculada a la Introducción a la Medicina General Integral, módulo interdisciplinario de las Ciencias médico-sociales, se contempla al Hombre desde un modelo sociobiológico y no biomédico.<br /> En el 4to. y 5to. semestres, se estudia estructurada en la disciplina Psicología Médica I y II. En el 6to. semestre, es integrada a Medicina Interna cuando el profesor de Psicología participa en la discusión de los problemas de salud.</span>
Microbubble‐Endothelial Cell Interactions as a Basis for Assessing Endothelial Function (2002)

Clinical signs and symptoms of coronary artery disease are predated in decades by endothelial dysfunction, an aberration in the vascular lining that permits the development and propagation of atherosclerotic lesions and vasomotor dysfunction in the arterial circulation. These ultimately lead to acute and chronic coronary ischemic syndromes. Other pathophysiologic scenarios encountered in clinical cardiology practice, such as cardiac transplant rejection and the period following coronary angioplasty or cardiac surgery, also are associated with endothelial dysfunction. Endothelial dysfunction parallels coronary risk factors and is potentially reversible, rendering early identification of the phenomenon a clinically important endpoint. Current methods for detecting endothelial dysfunction are limited, however. Myocardial contrast echocardiography using microbubbles targeted to bind to cell surface markers uniquely expressed by dysfunctional endothelial cells may offer an approach to the noninvasive detection of endothelial disease using clinical ultrasound imaging techniques. This article will discuss the concept of targeted ultrasound imaging and present preliminary studies in this area as applied to endothelial assessment. Potential applications to other disease states, both diagnostic and therapeutic, also are discussed.
VARACTOR LOADED TUNABLE PRINTED PIFA (2009)

Varactor tuned printed planar inverted-F antennas (PIFA) are investigated. The low-proflle printed antennas are fabricated together with the layouts of its DC control circuits and other RF/base- band circuit footprints. A surface mounted (SMT) varactor is applied as a frequency-tuning element at the middle of the long radiating arm in PIFA. Passive lumped DC bias circuits are implemented with good isolation. Both single and dual-band varactor tuned PIFA antennas are investigated. For a single-band PIFA, prototype designs show the in-band frequency (return loss is <10dB) is tunable from 1.6GHz to 2.3GHz when the bias voltage varies from 0V to 9.5V. Measured results show about 70»75% e-ciency and 2»3dB maximum gain. For a dual band PIFA with two varactor loadings, both the 800»900MHz and 1.7»2.2GHz bands are tuned individually by a varactor. By varying low-band capacitance, the operation frequency is tuned from 780MHz to 1020MHz, with little change on the higher frequency band. By varying high-band capacitance, the operation frequency is tuned from 1700MHz to 2140MHz, with little change on the lower frequency. Measurement shows antenna radiation e-ciencies within operation bands are about 55% at the low band and about 45% at the high band. The proposed frequency reconflgurable antennas could be useful for personal mobile terminal applications.
The concept of partial coherence in optics (1951)

Abstract It is shown that a ‘phase-coherence factor’ may be defined in a manner which leads, without recourse to explicit statistical analysis, to the theorems established by van Cittert (1934) and Zernike (1938) for analogous factors. An invalid approximation made in their calculations of the phase-coherence factor for a plane illuminated directly by a source is corrected. The new treatment is applied to the theory of Young’s experiment, the stellar interferometer, and illumination in the microscope. The phase-coherence factor defined here enables a general theory of the formation of optical images to be formulated. Further, it is shown that the diameter of the area of coherence on a plane illuminated by a source of angular radius α is given by d ═ 0⋅16λ/N sin α, where N is the refractive index of the intervening medium.
Fiber-optic pulsed photothermal radiometry for fast surface-temperature measurements (1998)

Temperature measurement based on pulsed photothermal radiometry is described. In this technique a body is irradiated by a laser pulse and its temperature is inferred from the shape of the emitted photothermal-signal curve. A prototypical system based on a pulsed CO(2) laser, an IR detector, and IR-transmitting silver halide optical fibers was constructed and used to evaluate the feasibility of this technique. An important feature of the technique is that changes in sample emissivity or geometric factors do not introduce errors in the temperature determination. Theory, simulation, and experimental results are given and discussed.
Activation of intestinal peroxisome proliferator-activated receptor-  increases high-density lipoprotein production (2012)

Peroxisome proliferator-activated receptor-α activation reduces cholesterol esterification, suppresses chylomicron, and increases HDL secretion by enterocytes. These results identify the intestine as a target organ of PPAR-α ligands with entero-hepatic tropism to reduce atherogenic dyslipidaemia.
Analysis of thermal relaxation during laser irradiation of tissue (2001)

Relatively simple calculations can be performed to estimate tau(eff) for known values of tau(r), T(peak) and DeltaT(base). The parameter tau(eff) may be a better estimate than tau(r) of tissue thermal relaxation during multiple-pulse laser irradiation.