gebhart/patrepeval huggingface dataset:
Selective Cytoprotection with Amifostine: A New Strategy in Supportive Care of Head and Neck Malignancies (1997)

<i>Objectives:</i> On the basis of the results of three phase II or phase III studies, we describe the possible role of the new selective cytoprotectant amifostine in the supportive treatment of patients with head and neck cancer. <i>Patients and Methods:</i> In 101 patients we investigated amifostine’s influence on the toxicity of a simultaneous radiochemotherapy (RCT) combined with carboplatin between May 1995 and April 1997. A first step was a pilot study (n = 14) during which amifostine was given prior to the second carboplatin cycle. This was followed by a randomized trial with 39 patients who received amifostine prior to every carboplatin infusion. A further 25 patients took part in an investigation about the intensification of a combined treatment (carboplatin plus 5-fluorouracil plus 70 Gy local radiation) under the protection of amifostine. In an ongoing phase III study, we included 37 patients. <i>Results:</i> Amifostine’s integration into the simultaneous RCT in head and neck cancer patients was very easy and led to a significant reduction of mucositis, dysphagia, and xerostomia as the main nonhe-matological side effects of the combined treatment. The hematological toxicities were also reduced. As a result of the reduced toxicity, we need less other supportive medications (thrombocyte transfusions, colony-stimulating factor, immunoglobulin). According to the first results, it should be possible with amifostine to intensify the RCT (increased local radiation dose, polychemotherapy) without significantly increased toxicity. Our data have not shown any sign of tumor protection due to amifostine. <i>Conclusions:</i> Amifostine offers the possibility to reduce the toxicity of RCT in head and neck cancer patients and to increase the acceptance of the combined regimen in this patient subgroup. The intensification of RCT should be the topic of future trials.
GENETICS AND REGULATION OF BACTERIAL LIPID METABOLISM (1989)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
SPARLS: A Low Complexity Recursive $\mathcal{L}_1$-Regularized Least Squares Algorithm (2009)

We develop a Recursive $\mathcal{L}_1$-Regularized Least Squares (SPARLS) algorithm for the estimation of a sparse tap-weight vector in the adaptive filtering setting. The SPARLS algorithm exploits noisy observations of the tap-weight vector output stream and produces its estimate using an Expectation-Maximization type algorithm. Simulation studies in the context of channel estimation, employing multi-path wireless channels, show that the SPARLS algorithm has significant improvement over the conventional widely-used Recursive Least Squares (RLS) algorithm, in terms of both mean squared error (MSE) and computational complexity.
Lower Mississippi. By Hodding Carter. The Rivers of America. Edited by Stephen Vincent Benet and Carl Carmer. (New York, Farrar & Rinehart, Inc., 1942. x + 437 pp. Bibliography and index. $2.50.) (1943)

Lower Mississippi. By Hodding Carter. The Rivers of America. Edited by Stephen Vincent Benét and Carl Carmer. (New York, Farrar & Rinehart, Inc., 1942. x + 437 pp. Bibliography and index. $2.50.) Get access Edwin Adams Davis Edwin Adams Davis Department of Archives, Louisiana State University Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 29, Issue 4, March 1943, Pages 634–635, https://doi.org/10.1093/jahist/29.4.634-a Published: 01 March 1943
Fault tolerant robust flight control using surface actuator hinge moments (2008)

A robust, flight control law is investigated to provide fault tolerance for air vehicles experiencing inertial state measurement sensor degradation. The method is particularly useful on low cost, precision weapons pursuing dynamic targets. Observation techniques are facilitated by representing the surface actuator aerodynamic induced hinge moment by a function that is Lipschitz within the actuator sweep angle. A stable output feedback flight control law, requiring only actuator angular position and current measurements, is designed to handle the hinge moment effects and track a predetermined angle-of-attack reference trajectory. Benefits include improved effectiveness, improved reliability without additional hardware, and a cost and weight savings. Simulations are conducted on a tactical missile interceptor to evaluate the controller at various operating conditions in the flight envelope.
Learning a Gaussian Process Prior for Automatically Generating Music Playlists (2001)

This paper presents AutoDJ: a system for automatically generating music playlists based on one or more seed songs selected by a user. AutoDJ uses Gaussian Process Regression to learn a user preference function over songs. This function takes music metadata as inputs. This paper further introduces Kernel Meta-Training, which is a method of learning a Gaussian Process kernel from a distribution of functions that generates the learned function. For playlist generation, AutoDJ learns a kernel from a large set of albums. This learned kernel is shown to be more effective at predicting users&apos; playlists than a reasonable hand-designed kernel.
THE INFLUENCE OF GROUPS IN THE MOLECULE OF 2: 3‐DIHYDRO‐3‐KETOBENZO‐1: 4‐THIAZINE ON ITS EFFECT ON LIVER FLUKE <i>(FASCIOLA HEPATICA) IN VITRO</i> (1952)

The parent compound chosen for the investigation described in this paper was 2 3-dihydro-3-ketobenzo-1: 4-thiazine (I), as it contains in its molecule certain features present in substances which possess anthelmintic properties, e.g. pheno- thiazine (II). It also contains a -CHCO-unit, which is a characteristic feature in filicic acid (III), the most important of the organic acids present in the anthelmintic Filix mas. 1 CO 6 0/2>H \N/',/C cHo 5
Adenauer or Schumacher? (1952)

Essay| February 01 1952 Adenauer or Schumacher? Felix E. Hirsch Felix E. Hirsch Professor of History and Librarian, Bard College Search for other works by this author on: This Site PubMed Google Scholar Current History (1952) 22 (126): 70–74. https://doi.org/10.1525/curh.1952.22.126.70 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Felix E. Hirsch; Adenauer or Schumacher?. Current History 1 February 1952; 22 (126): 70–74. doi: https://doi.org/10.1525/curh.1952.22.126.70 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1952 by The Regents of the University of California1952 Article PDF first page preview Close Modal You do not currently have access to this content.
Nonalcoholic Fatty Liver Disease for Identification of Preclinical Carotid Atherosclerosis (2016)

Nonalcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease, yet whether identification of NAFLD in asymptomatic individuals is helpful over established risk factors remains unknown. A total of 37,799 asymptomatic adults aged 20 years or older who underwent comprehensive health check-up examination, including abdominal and carotid artery duplex ultrasonography (US) were included in the analysis. Nonalcoholic fatty liver disease was diagnosed with US and exclusion of secondary causes of fat accumulation or other causes of chronic liver disease, and graded as mild or moderate to severe fatty liver. Individuals with carotid plaque identified on carotid artery US were considered at risk for cardiovascular disease. Metabolic syndrome (MetS) was defined by the adult treatment panel III criteria. Nonalcoholic fatty liver disease was an independent factor associated with carotid plaque in a dose-dependent manner (odds ratio [OR]; 95% confidence interval [CI]: 1.09 [1.03-1.16] and 1.13 [1.06-1.21] for mild and ≥ moderate degree of NAFLD). Among clinically-relevant subgroups, NAFLD was more closely associated with carotid plaque in young adults (aged < 60 years) without MetS (OR [95% CI]: 1.13 [1.03-1.19] and 1.16 [1.06-1.27] for mild and ≥ moderate degree of NAFLD) than old adults (aged ≥ 60 years) or with MetS (OR [95% CI]: 1.06 [0.97-1.17] and 1.07 [0.97-1.19] for mild and ≥ moderate degree NAFLD). In young adults without MetS, the prevalence of carotid plaques was 32.8% and the sensitivity and specificity of NAFLD for carotid plaque was 0.38 and 0.67, respectively. In conclusion, NAFLD is associated with carotid plaque independent of traditional risk factors, especially in young adults without MetS. Nonalcoholic fatty liver disease could help identify additional individuals with preclinical atherosclerosis in asymptomatic young adults without MetS, yet, showed suboptimal performance as a screening tool.
How the integration of traditional birth attendants with formal health systems can increase skilled birth attendance (2011)

The integration of TBAs with formal health systems increases skilled birth attendance. The greatest impact is seen when TBA integration is combined with complementary actions to overcome context-specific barriers to contact among SBAs, TBAs, and women.
Development and characterization of a human articular cartilage‐derived chondrocyte cell line that retains chondrocyte phenotype (2009)

Chondrocytes, the only cell type present in articular cartilage, regulate tissue homeostasis by a fine balance of metabolism that includes both anabolic and catabolic activities. Therefore, the biology of chondrocytes is critical for understanding cartilage metabolism. One major limitation when studying primary chondrocytes in culture is their loss of phenotype. To overcome this hurdle, limited attempts have been made to develop human chondrocyte cell lines that retain the phenotype for use as a good surrogate model. In this study, we report a novel approach to the establishment and characterization of human articular cartilage-derived chondrocyte cell lines. Adenoviral infection followed by culture of chondrocytes in 3-dimensional matrix within 48 h post-infection maintained the phenotype prior to clonal selection. Cells were then placed in culture either as monolayer, or in 3-dimensional matrix of alginate or agarose. The clones were characterized by their basal gene expression profile of chondrocyte markers. Based on type II collagen expression, 21 clones were analyzed for gene expression following treatment with IL-1 or BMP-7 and compared to similarly stimulated primary chondrocytes. This resulted in selection of two clones that retained the chondrocyte phenotype as evidenced by expression of type II collagen and other extra-cellular matrix molecules. In addition, one clone (AL-4-17) showed similar responses as primary chondrocytes when treated with IL-1 or BMP-7. In summary, this report provides a novel procedure to develop human articular cartilage-derived chondrocyte cell lines, which preserve important characteristics of articular chondrocytes and represent a useful model to study chondrocyte biology.
Comparison of a Performance-Based Test Results with Two Self-Reported Questionnaires in Determining the Rate of Disability in Patients with Chronic Low Back Pain (2011)

Objective: self-reported questionnaires and performance-based tests are the two methods of measuring the rate of disability in patients with chronic low back pain. The goal of this research was study of the influence of pain on these patients’ disability rate by comparing the findings of Roland-Morris Disability questionnaire (RMDQ) and Oswestry Disability Index (ODI) self-reported questionnaires with a performance-based test named Back Performance Scale (BPS). Methods and materials: This research is a cross sectional study and the study population were patients with nonspecific chronic low back pain. 75 patients 18 to 60 year-old age were enrolled through a convenient sampling. Back Performance Scale and the RMDQ and ODI questionnaires used to assess disability and the pain intensity was measured with VAS. Spearman correlation coefficient used for determining the correlation between pain and disability, and Pearson correlation coefficient used to determine the correlation between different modes of disability instruments. T-test used to compare the differences in disability rate between two groups of mild to moderate pain and severe pain. Results: The correlation coefficients between VAS and BPS, RMDQ and ODI were 0.37, 0.55 and 0.54 respectively (P<0.01), and correlation coefficients between BPS and RMDQ and ODI were 0.41 and 0.52 (P<0.001). Back Performance Scale showed no significant difference between two pain groups (P=0.139) but this difference was significant in the questionnaire results (P<0.01). Conclusion: Dissidence and the moderate correlation between the results of the self-reported questionnaires and Back Performance Scale showed that two methods of measures could represent different aspects in producing disability. Hence, making use of both instruments simultaneously is recommended to draw a holistic outline of the patients’ functional status.
I 2 NC: intra- and inter-session network coding for unicast flows in wireless networks (2013)

Abstract—In this work, we are interested in improving the performance of constructive network coding schemes in lossy wireless environments. We propose I 2 NC- an approach that combines inter-session and intra-session network coding and has two strengths. First, the error-correcting capabilities of intra-session network coding make our scheme resilient to loss. Second, redundancy allows intermediate nodes to operate without knowledge of the decoding buffers of their neighbors. Based only on the knowledge of the loss rates on the direct and overhearing links, intermediate nodes can make decisions for both intra-session (i.e., how much redundancy to add in each flow) and inter-session (i.e., what percentage of flows to code together) coding. Our approach is grounded on a network utility maximization (NUM) formulation of the problem. We propose two practical schemes, I 2 NC-state and I 2 NC-stateless, which mimic the structure of the NUM optimal solution. We also address the interaction of our approach with the transport layer. We demonstrate the benefits of our schemes through simulation in GloMoSim. Index Terms—Network coding, wireless networks, error correction, cross-layer optimization. I.
Sleep Deprivation Attack Detection in Wireless Sensor Network (2012)

Deployment of sensor network in hostile environment makes it mainly vulnerable to battery drainage attacks because it is impossible to recharge or replace the battery power of sensor nodes. Among different types of security threats, low power sensor nodes are immensely affected by the attacks which cause random drainage of the energy level of sensors, leading to death of the nodes. The most dangerous type of attack in this category is sleep deprivation, where target of the intruder is to maximize the power consumption of sensor nodes, so that their lifetime is minimized. Most of the existing works on sleep deprivation attack detection involve a lot of overhead, leading to poor throughput. The need of the day is to design a model for detecting intrusions accurately in an energy efficient manner. This paper proposes a hierarchical framework based on distributed collaborative mechanism for detecting sleep deprivation torture in wireless sensor network efficiently. Proposed model uses anomaly detection technique in two steps to reduce the probability of false intrusion.
The Isomerization of Alkyl Thiocyanates to Isothiocyanates (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Isomerization of Alkyl Thiocyanates to IsothiocyanatesPeter A. S. Smith and David W. EmersonCite this: J. Am. Chem. Soc. 1960, 82, 12, 3076–3082Publication Date (Print):June 1, 1960Publication History Published online1 May 2002Published inissue 1 June 1960https://pubs.acs.org/doi/10.1021/ja01497a025https://doi.org/10.1021/ja01497a025research-articleACS PublicationsRequest reuse permissionsArticle Views954Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Number of Interstitial Capillary Cross-Sections Assessed by Monoclonal Antibodies: Relation to Interstitial Damage (1990)

Using thin Plexiglass sections stained with silver, the peritubular capillary area and number of capillary cross-sections can predict both interstitial damage and plasma creatinine concentrations. This technique is both difficult to perform and time-consuming. We have restudied this topic using conventional cryostat sections from 46 biopsies with chronic glomerulonephritis and tubulointerstitial nephritis and two monoclonal antibodies (MoAb) recognising capillary endothelium. Seven pretransplant biopsies acted as controls. The number of capillary cross-sections/mm2 was counted, and the degree of tubular atrophy, interstitial fibrosis and cell infiltration of the interstitium independently assessed on a semiquantitative scale using paraffin sections. These results were correlated with the plasma creatinine or 51Cr-EDTA glomerular filtration rate. Mean number of capillary cross-sections in normal interstitium was 373 +/- 50/mm2, and in the 46 biopsies studied 242 +/- 57/mm2. The number of capillary cross-sections reflected the plasma creatinine (r = 0.82, P less than or equal to 0.0001) and the glomerular filtration rate (r = 0.64, P less than or equal to 0.0001) at the time of biopsy with greater accuracy than any of the conventional gradings of interstitial damage on paraffin sections. We conclude that the use of anti-endothelial cell monoclonal antibodies makes counting capillary cross-sections easy and reliable, and that this technique can be employed to assess the extent of interstitial damage in conventional cryostat sections.
ChiralC2-Symmetric CuII Complexes as Catalysts for Enantioselective Hetero-Diels-Alder Reactions (1998)

Air-stable and recyclable, the Cu<sup>II</sup> -(bis)oxazoline complex 1 efficiently catalyzes diastereo- and enantioselective hetero-Diels-Alder reactions between β,γ-unsaturated α-keto acid derivatives 2 and vinyl ethers for the synthesis of substituted dihydropyrans 3 [Eq. (1)]. Results of the crystal structure analysis of 1 in combination with calculations on model compounds indicate the formation of a reactive intermediate through replacement of the two H<sub>2</sub> O ligands with a chelating substrate. X=OEt, N(OMe)Me; R=alkyl, aryl, alkoxy, thiobenzyl.
Orientational diffusion reflects fiber structure within a voxel (2002)

Several new MR techniques have been introduced to infer direction through diffusion in multiple nerve fiber bundles within a voxel. To date, however, there has been no physical model reported to evaluate these methodologies and their ability to determine fiber orientation. In this article a model of diffusion analogous to nerve fibers is presented. Diffusion measurements at multiple closely spaced angles of 15 degrees in samples with different fiber orientations are compared with theoretical calculations for restricted diffusion in cylindrical geometry. Orientational diffusion measurements are shown to reflect fiber geometry and theoretical predictions to within 10%. Simulations of fiber crossings within a voxel suggest fiber orientation does not correspond to the direction of the largest measured diffusion coefficient, but theoretical knowledge of signal decay curves can predict the shape of these diffusion coefficient contours for given fiber orientation probabilities.
Data privacy (2004)

There is increasing need to build information systems that protect the privacy and ownership of data without impeding the flow of information. We will present some of our current work to demonstrate the technical feasibility of building such systems.
Synthesis of 2-pyridinecarboxylic acid by oxidation of potassium dichromate (2007)

The reaction conditions on oxidation of 2-methylpyridine to 2-pyridinecarboxylic acid by oxidation of potassium dichromate were studied.Effect of temperature,concentration,and ratio of reactants,sulfuric acid concentration and reaction time on the yield,the conversion and the selectivity were explored.The obtained product was characterized by IR,elemental analysis and melting point.The experiments showed that the optimum conditions are:the reaction temperature 105 ℃,the concentration of 2-methylpyridine 0.075 mol/L,the concentration ratio of K2Cr2O7 to 2-methylpyridine 2∶1,the concentration of sulfuric acid was 9 mol/L,the reaction time was 2 h.The highest yield was 87.7%,the conversion was 97.6%,and the selectivity was 89.8%.
Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories (1991)

The present document is the second of three parts in a review that focuses on recent data from clinical and animal research concerning the biochemical bases of depressive disorders, diagnosis, and treatment. Various receptor/transmitter theories of depressive disorders are discussed in this section. Specifically, data supporting noradrenergic, serotonergic, cholinergic, dopaminergic, GABAergic, and peptidergic theories, as well as interactions between noradrenergic and serotonergic, or cholinergic and catecholaminergic systems are presented. Problems with the data and future directions for research are also discussed. A previous publication, Part I of this review, dealt with the classification of depressive disorders and research techniques for studying the biochemical mechanisms of these disorders. A future publication, Part III of this review, discusses treatments for depression and some of the controversies in this field.