gebhart/patrepeval huggingface dataset:
Protein C activators in snake venoms. (1986)

Venoms of 32 snake species were tested for protein C (PC) activating potency. As measured with the chromogenic PC substrate D-Pro-L-Pro-L-Arg-pNA, eleven venoms were able to generate amidolytic activity from purified bovine PC. In five venom solutions (Bothrops moojeni, B. pradoi, Cerastes cerastes, Vipera lebetina and V. russellii) the PC activating potency was destroyed during 10 min heating at 70 degrees C at pH 3, whereas in six venom solutions (Agkistrodon contortrix contortrix, A. c. mokasen, A. c. pictigaster, Agkistrodon piscivorus, A. p. leucostoma and A. bilineatus) the PC activator was stable under these conditions. PC activator from A. c. contortrix (Protac) was purified to homogeneity and characterized as a single chain polypeptide with a molecular weight of approx. 39-42,000 Dalton. Protac does not exert proteinase activity and is not inhibited by proteinase inhibitors; PC activation with Protac seems to be a stoichiometric reaction. The use of Protac in quantitative PC determination bears significant advantages over the use of thrombin as an activator. In rabbits, i.v. injection of Protac caused a prolonged APTT and did not provoke acute toxic reactions.
Affinity Assays Using Fluorescence Anisotropy with Capillary Electrophoresis Separation (2004)

A novel approach to detecting affinity interactions that combines fluorescence anisotropy with capillary electrophoresis (FACE) was developed. In the method, sample is injected into a capillary filled with buffer that contains a fluorescent probe that possesses low fluorescence anisotropy. If proteins or other large molecules in the sample bind the fluorescent probe, their migration through the capillary can be detected as a positive anisotropy shift. Thus, the method provides both separation and confirmation of binding to the probe. Calculations based on combining the Perrin equation and dissociation constant were used to predict the effect of conditions on aniostropy detection. These calculations predict that low probe concentrations yield the best sensitivity while higher concentrations increase the dynamic range for detection of binding partner. The assay was applied to detection of G proteins using BODIPY FL GTPgammaS as the fluorescent probe. Experimental measurements exhibited trends in anisotropy with varying probe and protein concentrations that were consistent with the calculations. The limit of detection for G(alphai1) was 3 nM when the electrophoresis buffer contained 250 nM BODIPY FL GTPgammaS. FACE affinity assay is envisioned as a method that can quantify selected binding partners and screen complex samples for compounds that possess affinity for a particular small molecule that is used as a probe.
Optical Harmonic Generation Parametric Devices (1999)

Abstract The sections in this article are Nonlinear Optics: an Actual and Wide Field Of Optics Research Main Applications of Parametric Devices Induced Macroscopic Polarization Electromagnetic Energy Exchange Nonlinear Materials Propagation of the Waves in the Nonlinear Medium Second Harmonic Generation Optical Parametric Generators and Amplifiers Optical Parametric Oscillators Recent Advances in Frequency Conversion
Adaptive Joint Source-Channel Coding Using Multilevel codes for Unequal Error Protection and Hierarchical Modulation for SPIHT Image Transmission (2019)

A highly reliable and efficient wireless communication system for compressed images delivery is required in emerging multimedia applications. However, the transmission of the image can be attenuated by different factors mainly involved by the wireless communication multimedia systems. In the past decades, various source and channel coding schemes have been developed separately. In this paper, we investigate a joint source-channel coding scheme to improve the image transmission performance. Our main target is to reach a good tradeoff in terms of rate-distortion for Set Partitioning in Hierarchical Trees (SPIHT) image transmission. For the wireless communication part, we consider the Audio Visual PHY Ultra Wide Band IEEE 802.15.3c system. The proposed strategies rely on adaptive process applied for error protection and the modulation operations. Thus, error correcting codes for unequal error protection (UEP) of the compressed bit streams is included. Then, Hierarchical Modulation (HM) is applied to the different bits according to their importance levels. Full of simulations are performed and our results show image quality improvements at the receiver using multilevel UEP and Hierarchical Modulation compared to the ordinary joint source-channel coding system without introducing any extra bandwidth usage.
Oxidation Behavior of Intermetallic Compounds TiAl at High Temperatures (1989)

The oxidation behavior of the intermetallic compounds TiAl containing 34-38 mass%Al has been investigated in a temperature range between 1073 and 1223 K under an atmospheric pressure. The oxidation products have been examined by X-ray diffraction, scanning electron microscopy, and electron probe microanalysis. They are composed of four layers, i.e., TiO2, Al2O3, TiO2+Al2O3 and Ti3Al from the outer side.The mass gains during the oxidation obey the parabolic law, which increase rapidly at temperatures above 1073 K. An increase of Al content in TiAl does not change the oxidation resistance but decreases the quantity of spollation of the oxide scales during the cooling. As the oxidation rate of TiAl is lower than that of pure Ti, the existence of the Al2O3 layer have improved the oxidation resistance of TiAl. This Al2O3 layer, however, is not enough dense so as to prevent the oxidation above 1073 K.
Low postnatal serum IGF‐I levels are associated with bronchopulmonary dysplasia (BPD) (2012)

Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD.
New Products (2007)

In this issue, editors Eyal de Lara and Maria Ebling cover a mobile firewall with a USB form factor, a smart parking meter that can detect when a vehicle pulls in and out of a parking stall, and an initiative by the British government to outfit police officers with head-mounted cameras. They also present a Web-based voice communications service that lets users manage all their phones with a single virtual phone number and a service that turns the isolation of surfing the Web into a social networking opportunity.
A Low-level Simulation Study of Prioritization in IEEE 802.11e Contention-based Networks (2006)

This work deals with the performance evaluation of the IEEE 802.11e EDCA proposal for service prioritization in wireless LANs. A large amount of study has been carried out in the scientific community to evaluate the performance of the EDCA proposal, mainly in terms of throughput and access delay differentiation. However, we argue that further performance insights are needed in order to fully understand the principles behind the EDCA prioritization mechanisms. To this purpose, rather than limit our investigation on throughput and delay performance figures, we take a closer look to their operation also in terms of low-level performance metrics (such as probability of accessing specific channel slots). The paper contribution is threefold: first, we specify a detailed NS2 simulation model by enlightening the typical mis-configuration and errors that may occur when NS2 is used as simulation platform for WLANs and we cross-validate the simulation results with our custom-made C++ simulation tool; second, we describe some performance figures related to the different forms of prioritization provided by the EDCA mechanisms; finally, we verify some assumptions commonly used in the EDCA analytical models
Studies in sigmatropic rearrangements of N-prenylindole derivatives ? a formal enantiomerically pure synthesis of tryprostatin B (2006)

Rearrangement of Na-prenyl-Nb-acetyltryptamine, induced by BF3·Et2O at low temperature, leads to a 2-prenyl derivative, and thence to the tricyclic tryptamine 7 and the indoline 8. Similarly, Na-prenyl-Nb-phthaloyl-L-tryptophan methyl ester furnished the corresponding 2-prenyl derivative 16, a known advanced precursor of tryprostatin B. Density functional (B3LYP) calculations for the putative rearrangement transition state for N-prenylskatole show that prior coordination of BF3 to the indolic nitrogen changes the character of the subsequent sigmatropic pericyclic shifts from being entirely covalent to acquiring a significant degree of ionic character. The shifting prenyl group favours the endo over the exo mode of the transition state by 4.1 kcal mol−1.
5q-: pathogenetic importance of the common deleted region and clinical consequences of the entire deleted segment. (1994)

Partial deletion of chromosome 5q (5q-) is a frequent aberration in myelodysplasias and acute nonlymphocytic leukemias. It causes clinical and hematological symptoms termed the 5q-syndrome. Although more than 30 different 5q deletions are described, recent studies have demonstrated 5q31 as the common deleted region and have mapped a tumor suppressor (IRF-1) and a cluster of interleukin genes to 5q31. Furthermore, del(5)(q13q33) is associated with longer survival, which means that 5q segments other than 5q31 also are of importance. These data suggest that loss of the suppressor releases the malignancy, interleukin losses determine the hematology and deletion of other 5q segments affect survival.
Rational design of novel red‐shifted BRET pairs: Platforms for real‐time single‐chain protease biosensors (2009)

Bioluminescence resonance energy transfer (BRET) systems to date have been dominated by use of blue-green Renilla luciferase (Rluc) as the energy donor. Although effective in many cases, the expense and unfavorable biochemical attributes of the substrate (phenylcoelenterazine) limit utility of Rluc-based BRET systems. Herein we report a series of novel BRET pairs based on luciferases that utilize D-luciferin, resulting in red-shifted photonic outputs, favorable biochemical attributes, and increased efficacy. We developed a modified Förster equation to predict optimal BRET luciferase donor-fluorophore pairs and identified tdTomato as the optimal red fluorophore acceptor for click beetle green luciferase (CBG). A prototypical single-chain protease biosensor, capable of reporting on executioner caspase activity in live cells and in real-time, was generated by inserting a DEVD linker between CBG and tdTomato and validated in vitro with recombinant caspases and in cellulo with apoptosis-sensitive and -resistant cell lines. High signal-to-noise ratios ( approximately 33) and Z' factors (0.85) were observed in live cell longitudinal studies, sufficient for high-throughput screening. Thus, we illustrate a general methodology for the rational design of new BRET systems and provide a novel single-chain BRET protease biosensor that is long lived, red-shifted, and utilizes D-luciferin.
Famciclovir for the Treatment of Acute Herpes Zoster: Effects on Acute Disease and Postherpetic Neuralgia: A Randomized, Double-Blind, Placebo-Controlled Trial (1995)

Oral famciclovir, 500 mg or 750 mg three times daily for 7 days, is an effective and well-tolerated therapy for herpes zoster that decreases the duration of the disease's most debilitating complication, postherpetic neuralgia.
Development of gene-specific double-stranded RNA drugs (2004)

A relatively recent entrant into molecular biology--double-stranded RNA (dsRNA)--as a class exhibits a unique set of properties: relative stability, affinity for specific proteins and enzymes, ability to activate the interferon pathway and finally, RNA interference (RNAi). In RNAi, unique double-stranded short interfering RNA molecules (siRNA) destroy the corresponding target RNA with exquisite potency and selectivity, thus causing post-transcriptional gene silencing (PTGS). An understanding of the design of gene-specific dsRNA and development of techniques to deliver dsRNA in the cell and in live animals has heralded a new age of gene therapy without gene knockout. This review first summarizes the biological synthesis, metabolism and effect of the dsRNA with special emphasis on siRNA and RNAi. This is followed by the clinical, pharmacological and pharmaceutical prospects of the development of the dsRNA as a drug. It is clear that the dsRNA holds an enormous promise in the treatment of a large number of metabolic and infectious diseases including but not limited to cancer, macular degeneration, diabetic retinopathy, Alzheimer's and other neural disorders, autoimmune diseases, and all viral infections including AIDS (acquired immune deficiency syndrome), hepatitis and respiratory syncytial virus (RSV).
EEG Characteristics in Males at Risk for Alcoholism (1991)

Baseline EEG activity was recorded with eyes closed in 15 males, aged 19 to 24 at risk (HR = high risk) for the development of alcoholism and 15 matched controls (LR = low risk). Four EEG frequency bands were examined: slow alpha (7.5-10 Hz), fast alpha (10.25-12.75 Hz), slow beta (13-19.5 Hz) and fast beta (19.75-26 Hz). The HR and LR groups were compared on four measures of EEG activity for each frequency band: band power, absolute and relative area and laterality differences. Statistical analysis of the data via ANOVA revealed no significant difference between the HR and LR groups for any comparison. The results indicate that EEG measures prior to alcohol administration do not effectively discriminate between individuals at high and low risk for alcoholism.
SIPping from the data firehose (1997)

When mining large databases, the data extraction problem and the interface between the database and data mining algorithm become important issues. Rather than giving a mining algorithm full access to a database (by extracting to a flat file or other directly-accessible data structure), we propose the SQL Inter-face Protocol (SIP), which is a framework for inter-action between a mining algorithm and a database. The data continues to reside entirely within the data-base management system (DBMS), but the query in-terface to the database gives the data mining algorithm sufficient information to discover the same patterns it would have found with direct access to the data. This model of interaction brines several advantages; for ex-----ample, it allows a mining algorithm to be parallelized automatically just by using a parallelized DBMS to answer queries. We show how two families of mining algorithms may be implemented as “SIPpers, ” and we discuss related work in databases that should further enhance performance in the future.
Investigation of Intermodulation Distortion Reduction Technique for Multi-Channel Fiber-Radio Transmission in Heterogeneous Access Networks (2006)

We have analyzed a linearization scheme for optical single sideband with carrier (OSSB+C) modulated signals for fiber-radio applications that supports simultaneous baseband transmission for other wired access networks. Experimental results showed >9 dB improvement in the carrier-to-interference ratio (CIR) of the three-tone RF signals with simultaneous error-free 2.5 Gb/s baseband transmission. The carrier re-use scheme was quantified as a function of total RF channels, amplitude and channel spacing. It was found that as the number of RF channels increases at a fixed total input RF power, the baseband performance improves with RF channel spacing
Accumulation of an <i>E</i>,<i>E</i>,<i>E</i>‐Triene by the Monensin‐Producing Polyketide Synthase when Oxidative Cyclization is Blocked (2005)

Hinweise auf das Intermediat der Polyether-Biosynthese des ionophoren Antibiotikums Monensin A wurden erhalten: Die Verwendung von Streptomyces-cinnamonensis-Mutantenstämmen lieferte ein Tridecaketid-E,E,E-trien (siehe Formel), dessen Charakterisierung es ermöglicht, den wahrscheinlichen Biosyntheseweg zu Monensin zu bestimmen. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z501757_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Estimation of Acoustic Particle Motion and Source Bearing Using a Drifting Hydrophone Array Near a River Current Turbine to Assess Disturbances to Fish (2015)

Thesis (Master's)--University of Washington, 2015
Impairment of paravascular clearance pathways in the aging brain (2014)

We propose that impaired glymphatic clearance contributes to cognitive decline among the elderly and may represent a novel therapeutic target for the treatment of neurodegenerative diseases associated with accumulation of misfolded protein aggregates.
Re-encoding for low power state assignment of FSMs (1995)

Article Re-encoding for low power state assignment of FSMs Share on Authors: Vamshi Veeramachaneni Iowa State University, Ames, IA Iowa State University, Ames, IAView Profile , Akhilesh Tyagi Iowa State University, Ames, IA Iowa State University, Ames, IAView Profile , Suresh Rajgopal Intel Corp., Santa Clara, CA Intel Corp., Santa Clara, CAView Profile Authors Info & Claims ISLPED '95: Proceedings of the 1995 international symposium on Low power designApril 1995 Pages 173–178https://doi.org/10.1145/224081.224112Published:23 April 1995 9citation273DownloadsMetricsTotal Citations9Total Downloads273Last 12 Months8Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
OPTIMUM UTILIZATION AND SELECTION OF MOWERS FOR HIGHWAY R.O.W.S. (1965)

A STUDY OF ROADSIDE MOWING OPERATIONS WAS CONDUCTED IN LOUISIANA. THE OBJECTIVE OF THE STUDY WAS TO DETERMINE THE OPTIMUM SIZE AND COMBINATION OF MOWERS FOR ROADSIDE MOWING. AFTER STUDYING OPTIMIZATION PROCEDURES USED IN INDUSTRY, IT WAS CONCLUDED THAT LINEAR PROGRAMMING METHODS COULD BE APPLIED TO THE PROBLEM OF UTILIZING AND SELECTING ROADSIDE MOWING EQUIPMENT. THE BRITTANY MAINTENANCE UNIT, LOCATED IN THE LOUISIANA DEPARTMENT OF HIGHWAYS DISTRICT 61, WAS SELECTED AS A MODEL. THE ROADSIDES IN THE MODEL WERE SURVEYED TO DETERMINE THE AREA, PHYSICAL DIMENSIONS AND THE NUMBER AND TYPES OF OBSTRUCTIONS WITHIN EACH CONTROL SECTION. ROADSIDES WERE RATED AS TO EASE OF MOWING INTO SIX CLASSES. TIME AND MOTION STUDIES WERE CONDUCTED TO DETERMINE THE WORK DAY LENGTH AND FIELD CAPACITIES OF FOUR DIFFERENT TYPES OF MOWERS AS THEY OPERATED ON THE DIFFERENT CLASSES. THIS INFORMATION WAS THEN USED TO DETERMINE THE MOWING COSTS PER ACRE. A PROGRAMMED MOWING CYCLE WAS SET UP BY USING FIELD TEST DATA IN CONJUNCTION WITH LINEAR PROGRAMMING METHODS TO ASSIGN THE VARIOUS TYPES OF MOWERS TO DIFFERENT CLASSES OF ROADSIDES. THE ENTIRE MODEL WAS MOWED AS PROGRAMMED AND THE SOLUTION WAS FOUND TO BE FEASIBLE. THE ACTUAL OVERALL EQUIPMENT TIME REQUIRED TO MOW 1290 ACRES VARIED FROM THE PREDICTED EQUIPMENT TIME BY APPROXIMATELY 1 HOUR. HOWEVER, THE PREDICTED TIME OF MOWERS ON INDIVIDUAL ASSIGNMENTS VARIED CONSIDERABLY MORE. THE ASSIGNMENT PROCEDURE CAN BE ADAPTED TO ANY NUMBER OF RIGHT-OF-WAY CLASSES AND ANY NUMBER OF MOWERS. IT MAXIMIZES PRODUCTION OF AN EXISTING COMBINATION OF MOWERS WHILE MINIMIZING THE COST OF COMPLETING A MOWING CYCLE. THE PROCEDURE CAN ALSO BE USED TO SELECT OPTIMUM REPLACEMENT MOWERS. RECOMMENDATIONS WERE MADE FOR IMPLEMENTING THE PROCEDURE ON A STATE- OR DISTRICT-WIDE BASIS. /AUTHORS/
Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice (1992)

Nucleotide changes at both codons 317 and 321 in the VP2 capsid gene of the immunosuppressive strain of the murine parvovirus minute virus of mice, MVM(i), are required to create a virus capable of growing in A9 fibroblasts. This double mutant virus, ILB1, has growth characteristics very similar to those of the prototype fibrotropic strain MVM(p) in both single- and multiple-round infections of fibroblasts and is about 100-fold better at infecting fibroblasts than MVM(i). When only one nucleotide position is changed, either in codon 317 (as in ILB2) or in codon 321 (as in ILB3), the resulting viruses are less than twice as efficient as their parent MVM(i) at infecting fibroblasts. In the restrictive infection of A9 cells by the single mutants and MVM(i), gene expression and DNA replication were markedly reduced compared with ILB1 infection of the same cells or compared with infections of permissive hybrid cells by each of the viruses. This suggests that restriction acts predominantly at an early step in the infection. Since the phenotypes of ILB2 and ILB3 are essentially indistinguishable in restrictive infections, it is most likely that the individual loci affect the same step in the viral life cycle. The dramatic increase in fibroblast infectivity shown by ILB1 indicates a synergistic interaction between these two amino acid residues in the same rate-limiting process in fibroblast infection.
Nanoimprinted Polymer Solar Cell (2012)

Among the various organic photovoltaic devices, the conjugated polymer/fullerene approach has drawn the most research interest. The performance of these types of solar cells is greatly determined by the nanoscale morphology of the two components (donor/acceptor) and the molecular orientation/crystallinity in the photoactive layer. A vertically bicontinuous and interdigitized heterojunction between donor and acceptor has been regarded as one of the ideal structures to enable both efficient charge separation and transport. Synergistic control of polymer orientation in the nanostructured heterojunction is also critical to improve the performance of polymer solar cells. Nanoimprint lithography has emerged as a new approach to simultaneously control both the heterojunction morphology and polymer chains in organic photovoltaics. Currently, in the area of nanoimprinted polymer solar cells, much progress has been achieved in the fabrication of nanostructured morphology, control of molecular orientation/crystallinity, deposition of acceptor materials, patterned electrodes, understanding of structure-property correlations, and device performance. This review article summarizes the recent studies on nanoimprinted polymer solar cells and discusses the outstanding challenges and opportunities for future work.
On the optimal placement of web proxies in the Internet (1999)

Web caching or web proxy has been considered as the prime vehicle of coping with the ever-increasing demand for information retrieval over the Internet, the WWW being a typical example. Existing work on web proxy has primarily focused on content based caching; relatively less attention has been given to the development of proper placement strategies for the potential web proxies in the Internet. In this paper, we argue that the placement of web proxies is critical to the performance and further investigates the optimal placement policy of web proxies for a target web server in the Internet. The objective is to optimize a given performance measure for the target web server subject to system resources and traffic pattern. Specifically, we are interested in finding the optimal placement of multiple web proxies (M) among potential sites (N) under a given traffic pattern. We show this can be modeled a dynamic programming problem. We further obtain the optimal solution for the tree topology using O(N/sup 3/M/sup 2/) time.
Screening of soybean (Glycine max (L.) Merrill) genotypes for somatic embryo production from immature embryo. (1990)

Somatic embryo production was screened on 290 Glycine max (L.) MERRILL and 5 Glycine gracilis genotypes. Among them, we identified a G. max genotype which produced an outstanding number of somatic embryos.