gebhart/patrepeval huggingface dataset:
Picotesla magnetometry with coherent dark states (2001)

We investigate the experimental sensitivity limit of a scalar optical magnetometer based on coherent population trapping on the D2 line of a thermal cesium vapor. We find the expected strong dependence on averaging time, with a detection limit below 4 pT for integration times longer than 1 s, limited by slow drifts of the cell temperature and of the applied test magnetic-field itself. A detailed noise analysis shows that for shorter averaging times the demonstrated limit of about 12 pT/√Hz is dominated by the frequency noise of the laser source. The magnetometer can be operated for real-time detection in flux densities up to at least milliteslas and is robust enough for application outside the laser laboratory.
Left atrial appendage closure devices. Their role in 2013. (2013)

Stroke prevention is the major goal in treating patients with atrial fibrillation. Warfarin therapy, if used appropriately, is highly effective in preventing thromboembolic events, but is simultaneously burdened by a narrow therapeutic window, multiple food and drug interactions, and a substantial bleeding risk. New pharmacological agents show only a modest reduction of bleeding complications compared to warfarin. Percutaneous device left atrial appendage (LAA) closure has now been technologically advanced as an additional and potential alternative to pharmacotherapy in patients with AF. Promising randomized data are obtainable with the WATCHMAN® device, while several other devices are in various stages of clinical and preclinical development. In this article we review the current knowledge and status of this technique.
Genotypic Diversity among <i>Bacillus cereus</i> and <i>Bacillus thuringiensis</i> Strains (1994)

Twenty-four strains of Bacillus cereus were analyzed by pulsed-field gel electrophoresis (PFGE) and compared with 12 Bacillus thuringiensis strains. In addition, the 36 strains were examined for variation in 15 chromosomal genes encoding enzymes (by multilocus enzyme electrophoresis [MEE]). The genome of each strain had a distinct NotI restriction enzyme digestion profile by PFGE, and the 36 strains could be assigned to 27 multilocus genotypes by MEE. However, neither PFGE nor MEE analysis could distinguish between the two species. Two of the B. cereus strains contained extrachromosomal DNA that hybridized to a cryIA insecticidal toxin probe, and seven strains contained DNA with homology to a Tn4430 transposon probe derived from B. thuringiensis. The results strongly indicate that B. cereus and B. thuringiensis should be regarded as one species.
Th1 Cytokines Regulate Adenosine Receptors and Their Downstream Signaling Elements in Human Microvascular Endothelial Cells (2003)

We and others have shown that adenosine, acting at its receptors, is a potent modulator of inflammation and angiogenesis. To better understand the regulation of adenosine receptors during these processes we studied the effects of IL-1, TNF-alpha, and IFN-gamma on expression and function of adenosine receptors and select members of their coupling G proteins in human dermal microvascular endothelial cells (HMVEC). HMVEC expressed message and protein for A(2A) and A(2B), but not A(1) or A(3) receptors. IL-1 and TNF-alpha treatment increased message and protein expression of A(2A) and A(2B) receptor. IFN-gamma treatment also increased the expression of A(2B) receptors, but decreased expression of A(2A) receptors. Resting HMVEC and IFN-gamma-treated cells showed minimal cAMP response to the selective A(2A) receptor agonist 2-[2-(4-chlorophenyl)ethoxy]adenosine (MRE0094). In contrast, MRE0094 stimulated a dose-dependent increase in cAMP levels in TNF-alpha-treated cells that was almost completely blocked by the A(2A) receptor antagonist ZM-241385 (4-[2-[7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3-a][1,3,5]triazin-5-ylamino]ethyl]phenol). The nonselective adenosine receptor agonist 5'-(N-ethylcarboxamido)adenosine increased cAMP levels in both TNF-alpha- and IFN-gamma-treated cells, but not control cells, and its effect was only partially reversed by ZM-241385 in TNF-alpha-treated cells and not affected in IFN-gamma-treated cells. HMVEC expressed a higher level of G protein beta1 isoform than beta4 isoform. Although none of the cytokines tested affected G(beta1) expression, both IL-1 and TNF-alpha significantly up-regulated G(beta4) expression. These findings indicate that inflammatory cytokines modulate adenosine receptor expression and function on HMVECs and suggest that the interaction between proinflammatory cytokines and adenosine receptors may affect therapeutic responses to anti-inflammatory drugs that act via adenosine-dependent mechanisms.
High-Sensitivity Charge-Transfer-Type pH Sensor With Quasi-Signal Removal Structure (2014)

Charge-transfer-type pH sensors can be used to improve pH sensitivity with enhanced signal-to-noise ratio by applying the charge-accumulation technique. Theoretically, the pH sensitivity improves directly with the accumulated count. However, in a conventional sensor structure, a quasi-signal resulting from low charge transfer efficiency limits the accumulated count. In this paper, an effective solution to the problem of the quasi-signal and the novel sensor structure are investigated.
General theory of fractal path integrals with applications to many-body theories and statistical physics (1991)

A general scheme of fractal decomposition of exponential operators is presented in any order m. Namely, exp[x(A+B)]=Sm(x)+O(xm+1) for any positive integer m, where Sm(x)=et1A et2B et3A et4B⋅⋅⋅etMA with finite M depending on m. A general recursive scheme of construction of {tj} is given explicitly. It is proven that some of {tj} should be negative for m≥3 and for any finite M (nonexistence theorem of positive decomposition). General systematic decomposition criterions based on a new type of time-ordering are also formulated. The decomposition exp[x(A+B)]=[Sm(x/n)]n +O(xm+1/nm) yields a new efficient approach to quantum Monte Carlo simulations.
Resolution Enhancement of Spectra* (1970)

A numerical method has been developed to correct high-resolution infrared spectra for the distortion introduced by the spectrometer. The method involves, first, an accurate determination of the spectrometer response function and, then, deconvolution by a point-successive over-relaxation procedure. The method is applied to portions of the Q branches N2O and CH4 near 3.3 μ. The spectra are observed at pressures below 1.0 torr with spectrometer response-function half-widths less than 0.02 cm−1. The deconvolved spectra show an improvement of resolution which approaches the limit set by the Doppler widths of the lines. Line separations measured from the deconvolved spectra are within 0.001 cm−1 of the calculated values. The reduction of line overlap in the deconvolved spectra considerably increases the number of lines whose positions may be accurately measured.
Monolithic GaAs Blanking Upconverter (1989)

A wideband GaAs monolithic blanking upconverter is described to upconvert a frequency range of 0.1 - 0.5 GHz to 1.1 - 2.5 GHz. The upconverter consists of a wideband FET double balanced mixer, LO and IF input amplifiers, a novel actively matched 180° phase splitter and an RF amplifier. The upconverter provides a conversion gain of 8 dB, input and output VSWRs of less than 1.6 and a 40 dB on/off blanking capability. The high level of integration utilizing all active matching is realized in a small size of 1.22 × 1.22 mm. A good agreement between the simulated and measured results was obtained.
Research and Application of Data Archiving based on Oracle Dual Database Structure (2012)

For the universities' business system, to realize secure storage of historical data and long-term retention, saving high-end storage, online database backup pressure relief. A record-level data archiving method was proposed based on oracle dual database structure. This method included three aspects: related works, related technologies and strategy on data archive. For universities' business system, analysis of some problems need to concern and solution when the data archive, included four aspects: business analysis, storage analysis, data analysis and technical analysis. Finally, effectiveness of this method was validated by an application example in Tsinghua University. Index Terms—information flow, data management, data archiving, hierarchical storage management
Perception of affective and linguistic prosody: an ALE meta-analysis of neuroimaging studies (2013)

Prosody refers to the melodic and rhythmic aspects of speech. Two forms of prosody are typically distinguished: 'affective prosody' refers to the expression of emotion in speech, whereas 'linguistic prosody' relates to the intonation of sentences, including the specification of focus within sentences and stress within polysyllabic words. While these two processes are united by their use of vocal pitch modulation, they are functionally distinct. In order to examine the localization and lateralization of speech prosody in the brain, we performed two voxel-based meta-analyses of neuroimaging studies of the perception of affective and linguistic prosody. There was substantial sharing of brain activations between analyses, particularly in right-hemisphere auditory areas. However, a major point of divergence was observed in the inferior frontal gyrus: affective prosody was more likely to activate Brodmann area 47, while linguistic prosody was more likely to activate the ventral part of area 44.
Neural networks for blind decorrelation of signals (1997)

We analyze and extend a class of adaptive networks for second-order blind decorrelation of instantaneous signal mixtures. First, we compare the performance of the single-layer neural network employing global knowledge of the adaptive coefficients with a similar structure whose coefficients are adapted via local output connections. Through statistical analyzes, the convergence behaviors and stability bounds for the algorithms' step sizes are studied and derived. Second, we analyze the behaviors of locally adaptive multilayer decorrelation networks and quantify their performances for poorly conditioned signal mixtures. Third, we derive a robust locally adaptive network structure based on a posteriori output signals that remains stable for any step-size value. Finally, we present an extension of the locally adaptive network for linear-phase temporal and spatial whitening of multichannel signals. Simulations verify the analyses and indicate the usefulness of the locally adaptive networks for decorrelating signals in space and time.
Topology and migration-aware energy efficient virtual network embedding for green data centers (2014)

With the rapid proliferation of data centers, their energy consumption and green house gas emissions have significantly increased. Some efforts have been made to control and lower energy consumption of data centers such as proportional energy consuming hardware, dynamic provisioning and virtual-ization machine techniques. However, it is still common that many servers and network resources are often underutilized, and idle servers spend a large portion of their peak power consumption. We first built a novel model of a network virtualization in order to minimize energy usage in data centers for both computing and network resources by taking practical factors into consideration. Due to the NP-hardness of the proposed model, we have developed a heuristic algorithm for virtual network scheduling and mapping, considering expected energy consumption at different times, a data center architecture, and virtual network migration, as well as operation costs. Our evaluation results show that our algorithm could reduce energy consumption up to 40%, and take up to 57% higher number of virtual network requests over other existing virtual mapping schemes.
Analytics for software development (2010)

Despite large volumes of data and many types of metrics, software projects continue to be difficult to predict and risky to conduct. In this paper we propose software analytics which holds out the promise of helping the managers of software projects turn their plentiful information resources, produced readily by current tools, into insights they can act on. We discuss how analytics works, why it's a good fit for software engineering, and the research problems that must be overcome in order to realize its promise.
A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma (2010)

Pancreatic ductal adenocarcinoma is a disease of extremely poor prognosis for which there are no reliable markers of asymptomatic disease. To identify pancreatic cancer biomarkers, we focused on a genomic interval proximal to the most common fragile site in the human genome, chromosome 3p12, which undergoes smoking-related breakage, loss of heterozygosity, and homozygous deletion as an early event in many epithelial tumors, including pancreatic cancers. Using a functional genomic approach, we identified a seven-gene panel (TNC, TFPI, TGFBI, SEL-1L, L1CAM, WWTR1, and CDC42BPA) that was differentially expressed across three different expression platforms, including pancreatic tumor/normal samples. In addition, Ingenuity Pathways Analysis (IPA) and literature searches indicated that this seven-gene panel functions in one network associated with cellular movement/morphology/development, indicative of a "migration signature" of the 3p pathway. We tested whether two secreted proteins from this panel, tenascin C (TNC) and tissue factor pathway inhibitor (TFPI), could serve as plasma biomarkers. Plasma ELISA assays for TFPI/TNC resulted in a combined area under the curve (AUC) of 0.88 and, with addition of CA19-9, a combined AUC for the three-gene panel (TNC/TFPI/CA19-9), of 0.99 with 100% specificity at 90% sensitivity and 97.22% sensitivity at 90% specificity. Validation studies using TFPI only in a blinded sample set increased the performance of CA19-9 from an AUC of 0.84 to 0.94 with the two-gene panel. Results identify a novel 3p pathway-associated migration signature and plasma biomarker panel that has utility for discrimination of pancreatic cancer from normal controls and promise for clinical application.
Closed-loop glucose control in critically Ill patients using continuous glucose monitoring system (CGMS) in real time (2003)

A study was conducted to determine if continuous subcutaneous glucose monitoring (from MiniMed CGMS) could be used in real-time to control blood sugar level (BSL) in patients with critical illness. A closed-loop control system was constructed to use CGMS in a real-time manner, coupled with a proportional integral (PI) control algorithm based on a sliding scale approach, for automatic intravenous infusion of insulin to patients. A total of five subjects with high BSL (> 10 mmol/L) participated in formal studies of the closed-loop control system. Subjects were recruited from critically ill patients in the intensive care unit (ICU) after informed consent was obtained. Error grid analysis showed that 64.6% of the BSL readings as determined in real time using CGMS sensor, when compared to conventional BSL measurements on blood drawn from an arterial line, was clinically accurate (i.e., < 20% deviation from glucometer value). In the five patients who underwent closed-loop control, the controller managed to control only one patient's glycaemia without any manual intervention. Manual intervention was required due to the real-time sensor reading deviating more than 20% from the glucometer value, and also as a safety mechanism. Test on equality of mean and variance for BSL attained prior to, during, and post trial showed that the controller's performance was comparable to manual control. We conclude that the automatic sliding scale approach of closed-loop BSL control is feasible in patients in intensive care. More work is needed in the refinement of the algorithm and the improvement of real-time sensor accuracy.
Analytical method of chondroitin/dermatan sulfates using high performance liquid chromatography/turbo ionspray ionization mass spectrometry: application to analyses of the tumor tissue sections on glass slides (2001)

We established a highly sensitive quantitative analytical method for chondroitin/dermatan sulfates by LC/MS method. By this method, the unsaturated disaccharides produced after the enzymatic digestion of chondroitin/dermatan sulfates can be determined in the amounts as low as 0.5 pmol levels. The use of tetrabutylammonium hydroxide as an ion-pair reagent for LC/MS allowed us to separate unsaturated 4-sulfated disaccharide and unsaturated 6-sulfated disaccharide. Furthermore, the peak areas of unsaturated disaccharides were increased almost 10 times by the postcolumn addition of acetonitrile. We applied this LC/MS method to the analyses of unsaturated disaccharides from chondroitin/dermatan sulfates in the tissues sections on glass slides, which were prepared from MethA tumor-bearing mice. This method brought about considerable reduction in the time distance from sample collection to preparation of analytical results.
Evaluating Precipitable Water Vapor Products From Fengyun-4A Meteorological Satellite Using Radiosonde, GNSS, and ERA5 Data (2022)

Precipitable water vapor (PWV) products from the second generation of China’s geostationary meteorological satellite Fengyun-4A (FY-4A) have the advantage of high spatiotemporal resolution and can play an increasingly important role in the study of atmosphere and climate. Using the radiosonde, the global navigation satellite system (GNSS), and the European Centre for Medium-Range Weather Forecasts (ECMWF) ReAnalysis 5 (ERA5) reanalysis data, this study presented a comprehensive evaluation of PWV products from FY-4A for a one-year period from January 2019 to January 2020. Results indicated that FY-4A PWV data have a good agreement with radiosonde and GNSS measured ones with the same correlation coefficient of 0.976, and the root mean square errors (RMSEs) are 3.95 and 3.73 mm, respectively. Compared with the radiosonde and GNSS, the FY-4A Advanced Geostationary Radiation Imager (AGRI) was found to underestimate the water vapor during humid conditions when the PWV is greater than 50 mm. The magnitude of underestimation increases with the growth in water vapor content. In terms of spatial variability, the RMSE of FY-4A PWV decreases with the increase in latitude, while the relative RMSE (R-RMSE) displays an opposite pattern. RMSE from the comparison between FY-4A and ERA5 PWV varies from 0 to 6 mm depending upon the location. Statistics showed that 55.08%, 59.79%, and 83.13% RMSE values are less than 4 mm in the evaluation by radiosonde, GNSS, and ERA5, respectively. The seasonal and diurnal variations of RMSE showed that: 1) summer exhibited larger RMSE than winter and 2) daytime obtained slightly worse performance than nighttime.
Covalent binding of modified nucleic acids to proteins as a method for investigation of specific protein–nucleic acid interactions (2005)

Methods for specific covalent binding of modified nucleic acids to proteins and enzymes with conservation of their native structures are discussed. Possible applications of synthetic nucleic acids containing reactive (nucleophilic and electrophilic) groups and groups that can be photoactivated for testing protein–nucleic acid contacts and studying protein functioning are considered. The structures of protein–nucleic acid conjugates formed in the enzymatic reactions are described. Methods for the isolation and analysis of covalently bound protein–nucleic acid complexes are generalised. The main attention is given to methods for determination of protein sites attached to nucleic acids.
Automatic Control of Blood Volume Trends during Hemodialysis (1994)

Dialysis induced hypovolemia plays an important role in triggering intradialytic hypotension. The authors developed an automatic system (BVAC) with feedback changes in the ultrafiltration rate (UFR) and dialysate conductivity (DC) to match blood volume (BV) intradialytic profiles with the desired trajectories. The system consists of three subunits: (1) an optical probe to continuously detect the BV changes derived from hemoglobin changes, and (2) a dialysis machine interfaced with (3), a personal computer in which a time-dependent model is implemented. The model is based on a dynamic regulator that can set the actual BV changes against the corresponding desired values. Any discrepancy is offset by changes in UFR and DC. To verify the efficacy of the BVAC system in reducing intradialytic cardiovascular instability, five hypotension-prone patients were studied during a three period protocol (A1-B-A2) that lasted six sessions per period per patient. During periods A1 and A2, the dialysis procedure was conventional hemodialysis (HD) with linear UFR and constant DC. During period B, both UFR and DC were automatically regulated by the BVAC system. Mean BV reduction and its variability were lower during period B than during periods A1 and A2 (-10.2%, -11.3%, and -11.5, respectively). Episodes of hypotension were significantly (P < 0.05) fewer during period B (n = 1) than during periods A1 (n = 8) and A2 (n = 5). The therapeutic interventions defined as infused milliliters of isotonic and hypertonic solution were fewer during period B compared with periods A1 and A2. Total UF and end-dialysis plasma sodium concentrations did not differ in the three study periods. BVAC was effective in improving cardiovascular tolerance to treatment.
ROENTGENOGRAPHIC AIDS IN DIAGNOSIS OF NEOPLASMS OF LIVER AND EXTRAHEPATIC DUCTS (1959)

The histories of 35 patients with primary carcinoma of the gallbladder were reviewed in order to assess the diagnostic value of data obtained by preoperative roentgenography. The customary upper gastrointestinal series of roentgenograms showed signs of extrinsic pressure on the duodenum in 10 of 32 cases in which such a series was made. A plain film of the abdomen revealed a mass in the right upper quadrant in 3 of 24 cases. Oral cholecystography was carried out in 26 cases, 4 of which showed opacification of the biliary system. Newly developed roentgenographic techniques are helpful in selected cases and sometimes furnish decisive information. The diagnosis of polypoid growths within the gallbladder is occasionally settled by the finding of a solitary fixed filling defect on cholecystography and is an indication for cholecystectomy.
Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs (2014)

The major challenges of aging research include absence of the comprehensive set of aging biomarkers, the time it takes to evaluate the effects of various interventions on longevity in humans and the difficulty extrapolating the results from model organisms to humans. To address these challenges we propose the in silico method for screening and ranking the possible geroprotectors followed by the high-throughput in vivo and in vitro validation. The proposed method evaluates the changes in the collection of activated or suppressed signaling pathways involved in aging and longevity, termed signaling pathway cloud, constructed using the gene expression data and epigenetic profiles of young and old patients' tissues. The possible interventions are selected and rated according to their ability to regulate age-related changes and minimize differences in the signaling pathway cloud. While many algorithmic solutions to simulating the induction of the old into young metabolic profiles in silico are possible, this flexible and scalable approach may potentially be used to predict the efficacy of the many drugs that may extend human longevity before conducting pre-clinical work and expensive clinical trials.