gebhart/patrepeval huggingface dataset:
A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling (2009)

In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilizing human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven. Bone formation occurred after eight weeks when a minimum of one million HPDCs was loaded on Collagraft carriers and implanted subcutaneously in NMRI nu/nu mice. De novo bone matrix, mainly secreted by the HPDCs, was found juxta-proximal of the calcium phosphate (CaP) granules suggesting that CaP may have triggered the 'osteoinductive program'. Indeed, removal of the CaP granules by ethylenediaminetetraacetic acid decalcification prior to cell seeding and implantation resulted in loss of bone formation. In addition, inhibition of endogenous bone morphogenetic protein and Wnt signalling by overexpression of the secreted antagonists Noggin and Frzb, respectively, also abrogated osteoinduction. Proliferation of the engrafted HPDCs was strongly reduced in the decalcified scaffolds or when seeded with adenovirus-Noggin/Frzb transduced HPDCs indicating that cell division of the engrafted HPDCs is required for the direct bone formation cascade. These data suggest that this model of bone formation is similar to that observed during physiological intramembranous bone development and may be of importance when investigating tissue engineering strategies.
Challenges in Using of Distributed Wireless Mesh Networks in Emergency Response (2006)

Wireless Mesh Networks (WMNs) are formed by self-organized wireless nodes that use multi-hop wireless relaying. These networks are useable in a variety of situations ranging from fixed residential broadband networking based on rooftop wireless mesh nodes to emergency response networks for handling large scale disasters. Quick deployability, minimal configuration, broadband communication, and easiness of reconfigurability are the major characteristics that make WMNs a suitable choice for emergency applications. There exist several open research issues in using such WMNs for emergency response applications. We, in this paper, present a hybrid distributed wireless networking architecture, Extreme Networking System (ENS), and present large set of performance observations collected from a real distributed hybrid wireless mesh network used for supporting a medical emergency response application. We present the traffic behavior observed in our network when a client server medical emergency response application is employed. The performance observations on real-traffic scenarios for emergency response application underlines the need for focusing further research on topology control, reliability, service availability, and distributed management. We observed that though there are several challenges that need to be solved, a WMN is a favorable choice for emergency response networking.
Development of a Superconducting Helical Undulator for a Polarised Positron Source (2006)

A method of producing a polarised positron beam from e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> pair production in a target by circularly polarised γ-radiation is being investigated. Polarised photons are to be generated by the passage of a high energy electron beam (250 GeV as anticipated in the International Linear Collider - ILC) through a helical undulator. For production of 20 MeV photons, an undulator with a period of 14 mm, a bore of approximately 4 mm and magnetic field on axis of 0.8 T is required. First prototypes have been constructed using both superconducting and permanent magnet technologies which are capable of producing the necessary magnetic field configuration in the undulator. This paper details the design, construction techniques and field measurement results of the first superconducting prototype and compares the results with simulation.
Heart rate variability during the acute phase of myocardial infarction. (1992)

HR variability during the early phase of AMI is decreased and is significantly related to clinical and hemodynamic indexes of severity. The causes for the observed changes in HR variability during AMI may be reduced vagal and/or increased sympathetic outflow to the heart. It is suggested that early measurements of HR variability during AMI may offer important clinical information and contribute to the early risk stratification of patients.
Nanosheet thickness-modulated MoS<sub>2</sub>dielectric property evidenced by field-effect transistor performance (2012)

We report on the nanosheet-thickness effects on the performance of top-gate MoS(2) field-effect transistors (FETs), which is directly related to the MoS(2) dielectric constant. Our top-gate nanosheet FETs with 40 nm thin Al(2)O(3) displayed at least an order of magnitude higher mobility than those of bottom-gate nanosheet FETs with 285 nm thick SiO(2), benefiting from the dielectric screening by high-k Al(2)O(3). Among the top-gate devices, the single-layered FET demonstrated the highest mobility of ∼170 cm(2) V(-1) s(-1) with 90 mV dec(-1) as the smallest subthreshold swing (SS) but the double- and triple-layered FETs showed only ∼25 and ∼15 cm(2) V(-1) s(-1) respectively with the large SS of 0.5 and 1.1 V dec(-1). Such property degradation with MoS(2) thickness is attributed to its dielectric constant increase, which could rather reduce the benefits from the top-gate high-k dielectric.
Intense oxidative DNA damage promoted by <scp>l</scp>‐DOPA and its metabolites implications for neurodegenerative disease (1994)

Oxidative DNA damage can cause mutation and cell death. We show that l ‐DOPA, dopamine and 3‐ O ‐methyl‐DOPA cause extensive oxidative DNA damage in the presence of H 2 O 2 and traces of copper ions. 8‐Hydroxyguanine is the major product. Iron ions were much less effective and manganese ions did not catalyse DNA damage. We propose that copper ion release, in the presence of l ‐DOPA and its metabolites, may be an important mechanism of neurotoxicity, e.g. in Parkinson's disease and amyotrophic lateral sclerosis.
A unified version model for configuration management (1995)

Integration of configuration management (CM) tools into software development environments raises the need for CM models to interoperate through a unified CM model. A possible foundation is the version set model, a unified model for specifying versions and version operations, where versions, components, and aggregates are grouped into sets according to their features, using$eature logic as a formal base to denote sets and operations and deduce consistency. Version sets generalize well-known CM concepts such as components, repositories, workspaces, aggregates, or configurations and allow for unprecedented flexibility in combining these concepts, Arbitrary revisionhwiant combinations of components and aggregates are modeled in a uniform and orthogonal way. We show how the concepts of four central configuration management models-the checlchdcheckout model, the change set model, the composition model, and the long transaction model-are encompassed and combined
Enhanced superchannel transmission using phase conjugation (2015)

We demonstrate polarisation insensitive dual-band optical phase conjugation for multiple 400Gbit/s optical superchannels using a Raman amplified transmission link with a realistic span length of 75km. The resultant increase in transmission distance is confirmed analytically.
A sub-1 mA 1.5-GHz silicon bipolar dual modulus prescaler (1994)

This paper describes a 2.7-V dual modulus (/spl divide/64/65, /spl divide/128/129) prescaler that operates up to 1.5 GHz with a power consumption of 1.97 mW (Vcc=2.3 V, Icc=860 /spl mu/A). The prescaler also incorporates a stand-by mode feature, which reduces its power dissipation to 0.12 mW when enabled. This performance has been achieved on a 0.8-/spl mu/m advanced bipolar technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Optimization of Fluorescence Measurements (1988)

Various components of a conventional fluorometer are discussed. Several approaches to optimization of some of these components are discussed by citing specific research examples. The four areas of research that are described include: stabilization of a xenon arc lamp, improvements in sample chemistry, increased detector selectivity, and development of data reduction strategies for complex data. Improvements in the fluorescence measurement process are cited with each example.
Drive-reinforcement learning: a self-supervised model for adaptive control (1990)

A network of two self-supervised simulated neurons using the drive-reinforcement rule for synaptic modification can learn to balance a pole without experiencing failure. This adaptive controller also responds quickly and automatically to rapidly changing plant parameters. Other aspects of the controller's performance investigated include the controller's response in a noisy environment, the effect of varying the partitioning of the state space of the plant, the effect of increasing the controller's response time, and the consequences of disabling learning at the beginning of a trial and during the progress of a trial. Earlier work with drive-reinforcement learning supports the claim that the theory's neuronal model can account for observed phenomena of classical conditioning; this work constitutes progress toward demonstrating that useful adaptive controllers can be fabricated from networks of classically conditionable elements.
Synergistic Inhibition of Intracellular Hepatitis C Virus Replication by Combination of Ribavirin and Interferon‐α (2004)

Treatment of hepatitis C virus (HCV) infection with interferon (IFN)- alpha and ribavirin combination therapy results in superior clinical antiviral responses than does monotherapy with IFN. To explore the virological basis of the effects of combination therapy, we analyzed the effects of IFN- alpha and ribavirin, singly and in combination, on intracellular HCV replication by use of an HCV replicon system. A new replicon that expressed a selectable chimeric reporter protein comprising firefly luciferase and neomycin phosphotransferase was constructed. The replicon was highly sensitive to IFN-alpha (50% inhibitory concentration [IC(50)], 0.5 U/mL). Therapy with ribavirin showed weak suppression of HCV replication at a lower concentration (IC(50), 126 mu mol/L). The nucleotide sequence diversity of the replicon was increased significantly by therapy with ribavirin, suggesting that error-prone HCV replication was induced by the drug. Importantly, use of a clinically achievable concentration of ribavirin (approximately 10 mu mol/L) in combination with IFN showed strong synergistic inhibitory effects on HCV replication. Our results suggest that the direct effects of ribavirin on the genetic stability of the HCV subgenome and its synergistic action combined, with IFN-alpha, may explain the improved clinical responses to combination therapy.
WDM all-fiber compound devices: bimodal fiber narrowband tap and equal-arm dissimilar-fiber unbalanced Mach-Zehnder interferometer (1990)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text K. O. HILL, F. BILODEAU, B. MALO, and D. C. JOHNSON, "WDM all-fiber compound devices: bimodal fiber narrowband tap and equal-arm dissimilar-fiber unbalanced Mach-Zehnder interferometer," in Optical Fiber Communication, OSA Technical Digest (Optical Society of America, 1990), paper WM2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A scalable multicomputer (2002)

Computer uses are being expanded beyond the capabilities of stand-alone machines to applications requiring high throughput and computational power as well as low cost which can only be found in multicomputers. In this paper we describe a currently developing multicomputer constructed with the interconnections of many computers on a network where each computer performs a task so that the combined efforts of all the computers can be used to solve problems beyond the capability of any single machine to solve. We address four aspects of this multicomputer: hardware, software, applications, and future work efforts.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome (2020)

COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Without ACE2 acting as a guardian to inactivate the ligands of B1R, the lung environment is prone for local vascular leakage leading to angioedema. Here, we hypothesize that a kinin-dependent local lung angioedema via B1R and eventually B2R is an important feature of COVID-19. We propose that blocking the B2R and inhibiting plasma kallikrein activity might have an ameliorating effect on early disease caused by COVID-19 and might prevent acute respiratory distress syndrome (ARDS). In addition, this pathway might indirectly be responsive to anti-inflammatory agents.
Germ line chimera produced by transfer of cultured chick primordial germ cells. (1995)

Intrinsic primordial germ cells (PGCs) from stage 27 (5-day-old) chick embryonic germinal ridges were cultured in vitro for a further 5 days, and shown to proliferate on stroma cells derived from the germinal ridge. To determine whether these cultured PGCs could colonize and contribute to the germ-line, PGCs were isolated by gentle pipetting, labeled with PKH26 fluorescent dye and injected into the blood stream of stage 17 (2.5-day-old) chick embryos. The recipient embryos were incubated until they reached stage 28. Thin sections of these embryos were analysed by fluorescent confocal laser microscopy. These analyses showed that the labeled donor PGCs had migrated into the germinal ridges of the recipient embryos, and transplanted PGCs had undergone at least 3-7 divisions. These results suggest that PGCs that had passed far beyond the migration stage in vivo were still able to migrate, colonize and proliferate in recipient chick embryonic gonads.
Development and mechanization of libraries of the University of California (1965)

カリフォルニア州立大学はアメリカ合衆国において最大の規模を有し，1964年秋における学生数は約7万，1970年には約10万に達する。キャンパスは加州全体にわたり9ヶ所に在り，その蔵書数の合計は700万冊に及ぶ。このような大規模の図書館組織における利用および蔵書構成ならびに事務処理を統制する上で，大学図書館評議会の果す役割は極めて大きい。この評議会は，各キャンパスの図書館長，バークレー及びロスアンジェルスの図書館学校長，および州全般の学事を管掌する大学研究調査部長から構成され，図書館の開発計画を作成した。その内容の要点は，1）大学図書館群は学術コレクションの共同プールと見なされ，2）共同計画を実行に移すことにより増大する利用者へのサービスを確保すると共に，資料購入費の増加をはかり，3）資料の不必要な重複を避けることにある。評議会はこの他にも，各種の共同作業計画を立てたが，その中の重要なものの一つに，二大保存図書館設立の計画がある。北部に散在するキャンパスに対してはリッチモンドに古くからある図書館を改装して利用し，南部に関してはUCLAのキャンパスに新らしく建造の予定である。また，キャンパス間における図書館相互貸借システムの発展も意図され，通信運輸手段の改善だけでなく，相互貸借用図書収集および写真複製機器の設備のための予算獲得も試みられた。キャンパス間の蔵書利用促進のためには，1962年および1963年にUCLA図書館の辞書体目録ならびにバークレー図書館の著者名目録を冊子体に編成して刊行配布したが，1967年刊行予定の補遺第1号は，1962年から1967年までの全大学図書館の全増加図書を包含することになっている。別に，南部三キャンパスのそれぞれに合計7.5万冊に達する学部学生用図書を収集することも，計画の一端として実施に移された。その他建築基準の設置，図書館の地位および給与改善に関する常設委員会も評議会内に設けられ，活躍している。しかし，評議会の最大の成果であり，影響力が甚大であると考えられるものは，1961年に提案され2年後に成立した図書館研究所の設置であろう。この研究所はその支所をバークレーとロスアンジェルスの図書館学校にそれぞれ設置しているが，その活動にはすべての図書館が参画する。諮問機関としては，大学総長に任命された教授よりなる委員会および図書館評議会がある。研究所の目的は，図書館および情報処理に関する問題の解明，両者に関するシステムの改善ならびに図書館学教育の高度化にある。その長期計画の中には，大学図書館の使命，研究方法および研究者の要求の変遷，記録情報の発展と複雑性，多図書館間組織，情報源および情報システムの進化などに関する研究が含まれている。この他，図書館資料およびサービスの価値の経済的分析法，ファイルの効率測定，などの基本的問題および機械語に書誌的データを変換する方法などの調査も計画され，中央のセンターと地方のそれで行われるべき索引深度の決定ならびに作成された索引の集中・交換利用に関わる研究も意図されている。別に，大学図書館に直接的価値を持つ特定の研究も行われるが，その中には，図書館におけるコスト測定法，配本技術―特にキャンパス間に於て電子工学等を利用した印刷資料の内容の送達―，現存の機械化組織の図書館業務に対する応用，冊子体目録の作成と累積などが数えられるが，これらの諸問題の解決に当り，近い将来研究所に実行班が設けられることが希まれている。図書館業務の機械化の実際は，冊子体目録作成の他，貸出業務，逐次刊行物に関する記録に見られるが，近い将来に於て，国立医学図書館のメドラー・システムとの連携作業が行われることになっている。貸出業務の機械化はパンチカードを利用して行われ，ソーターを用いて毎日期限超過の貸出カードを探し出すと共に，当日の貸出冊数を計算する。この方法はデーヴィス・キャンパスで行われているが，ロスアンジェルスのキャンパスでは，IBMのトランザクション・カード・システムを利用し，さらに詳細なデータが得られるようになっている。逐次刊行物の記録作成に関しては，パンチカードと磁気テープが併用される。逐刊物の受入れに関しては，毎月受入れ予定のファイルがパンチカードから作られ，刊行物を毎日受け入れるごとにチェックし，それから受入れ日報を作成し，後にまとめて月報の形にする。その他このシステムを利用し，所蔵逐刊物リスト，受入れリスト，合本リスト，欠号リスト，クレイム・リストなどが作成される。メドラー・システムには，ロスアンジェルスの生物学・医学図書館が参加し，同システムに蓄積された情報を上記キャンパスの機械で利用しうるように変換送付している。この他，既に発注業務にも機械が利用されているが，相互に関連しうる機械化システムを開発することにより，全大学の図書館がより緊密に協調することが期待されている。（M. F.）
Glucose Sensor Characteristics for Miniaturized Portable Closed-Loop Insulin Delivery: A Step Toward Implantation (1982)

An implantable glucose sensor must be free of baseline and sensitivity drift. To our knowledge, a drift-free glucose sensor with fast response time is not currently available. We are therefore proposing a miniature extracorporeal glucose sensor with access to the vascular system as a practical step toward implantation. This sensor could use existing technology to form the basis of a patient-wearable closed-loop system.
Catalytic Molecular Beacons (2001)

We have constructed catalytic molecular beacons from a hammerhead-type deoxyribozyme by a modular design. The deoxyribozyme was engineered to contain a molecular beacon stem-loop module that, when closed, inhibits the deoxyribozyme module and is complementary to a target oligonucleotide. Binding of target oligonucleotides opens the beacon stem-loop and allosterically activates the deoxyribozyme module, which amplifies the recognition event through cleavage of a doubly labeled fluorescent substrate. The customized modular design of catalytic molecular beacons allows for any two single-stranded oligonucleotide sequences to be distinguished in homogenous solution in a single step. Our constructs demonstrate that antisense conformational triggers based on molecular beacons can be used to initiate catalytic events. The selectivity of the system is sufficient for analytical applications and has potential for the construction of deoxyribozyme-based drug delivery tools specifically activated in cells containing somatic mutations.
The Chinese in the United States of America. (1962)

Journal Article The Facts of American Life Get access The Facts of American Life. Ed. by M. B. Schnapper. Washington, Public Affairs Press, 1960. vi+420 pp. Index. $6. E. G. C. E. G. C. Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 38, Issue 1, January 1962, Page 135, https://doi.org/10.2307/2611482 Published: 01 January 1962
Moisture-assisted subcritical debonding of a polymer/metal interface (2002)

Subcritical debonding of polymer/metal interfaces has important implications for the reliability of a range of modern device technologies containing thin layered structures, although the physics of the underlying crack-growth mechanisms are not well understood. This study investigates the effect of moisture on subcritical debonding at the interface between a silica-filled epoxy resin and a copper substrate electroplated with a nickel layer. Subcritical debond-growth rates in the range of 10−5 to 10−11 m/s were characterized as a function of the applied strain energy release rate, GA. Particular attention was given to the relationship between the debond tip strain energy release rate, Gtip, and the measured debond growth rates. The kinetics of interfacial debond growth were rationalized in terms of a stress-dependent chemical reaction and mass transport of the environmental species to the debond tip. The order of the chemical reaction with respect to water was determined and found to be surprisingly high (n∼5). In the transport-controlled region, the rate of debond growth was found to increase linearly with the partial pressure of water vapor. The effects of salient interface parameters including the peak stress in a cohesive zone used to model the fracture mechanism were explored.
Peers-assisted dynamic content distribution networks (2005)

Content distribution networks (CDNs) have been proposed to primarily distribute Web and some limited streaming audio/video content over the Internet. Current CDNs consist of fixed content nodes placed at strategic locations on the Internet to improve the service latency and to reduce server and network load. Although the approach of delivering content with a fixed CDN has enjoyed some successes, it is often difficult to upgrade and extend a CDN to serve more users due to a very high deployment cost. In this paper, we propose that a CDN be agile while delivering content. We make the case for a dynamic CDN architecture in which a CDN leverages local peers to deliver the CDN's content to local users. We define a formal problem for using peers to increase the capacity of a CDN and we propose an algorithm to help a CDN to dynamically recruit local peers to be part of the CDN. The CDN and the recruited local peers cooperate to serve content to other local users. Our performance evaluation shows promising results with the new dynamic CDN architecture. Our simple CDN growing strategies dramatically improve the average service latency in streaming video content
Stress, Aging, and Neurodegenerative Disease (2006)

Molecular pathways that modulate neurotoxicity of the β-amyloid peptide have been delineated; these are controlled by another pathway that modulates aging.
Rate Control (2006)

2] The systemic effects of calcium channel antagonists and -adrenergic receptor antagonists on blood pressure and other adverse effects, however, may limit use of these agents in some patients. In other patients, it may be difficult to achieve adequate rate control with the use of pharmacological agents.
Diode pumping of a blue (473 nm) Nd:YAG/KNbO/sub 3/ microchip laser (1996)

Summary form only given. All-solid-state compact blue and green lasers are required for low-power applications in the medical and reprographics industries. Our group recently reported 13 mW of green and 1 mW of blue radiation generated from diode-pumped composite-material microchip devices. In addition Zarrabi et al. generated 15 mW of blue radiation from a Ti:sapphire laser-pumped Nd:YALO/KNbO/sub 3/ microchip. We report here on a diode-array-pumped Nd:YAG/KNbO/sub 3/ blue microchip laser generating over 25 mW and 5 mW of 473 nm radiation using a 1.2 W and 0.5 W diode array respectively.
Differential Hypomethylation of the c-MYC Protooncogene in Bladder Cancers at Different Stages and Grades (1989)

The 5-methylcytosine content of c-myc proto-oncogene DNA obtained from samples of normal bladders and of bladders with transitional cell carcinoma of different stage and grade was analyzed. Five CCGG sites (from the third coding region to the 3' flanking region of the gene) which showed different methylation in normal and neoplastic samples were identified. The overall c-myc methylation levels were significantly reduced in carcinomas. Furthermore, a significant correlation between disease invasiveness and methylation level was found. Nevertheless, in each group of patients with the same histological grade, heterogeneity has been observed. This might be suggestive of different prognosis of the disease.