gebhart/patrepeval huggingface dataset:
Stereospecific binding of rac-iron(III) N,N'-ethylenebis[(5-bromo-2-hydroxyphenyl)glycinate] to the bilirubin site on human serum albumin (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific binding of rac-iron(III) N,N'-ethylenebis[(5-bromo-2-hydroxyphenyl)glycinate] to the bilirubin site on human serum albuminRandall B. Lauffer, Alice C. Vincent, Sreenivasan Padmanabhan, and Thomas J. MeadeCite this: J. Am. Chem. Soc. 1987, 109, 7, 2216–2218Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00241a068https://doi.org/10.1021/ja00241a068research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Time From Treatment to Subsequent Diagnosis of Brain Metastases in Stage III Non–Small-Cell Lung Cancer: A Retrospective Review by the Southwest Oncology Group (2005)

PURPOSE A retrospective review of the Southwest Oncology Group (SWOG) database was undertaken to review the incidence and timing of diagnosis of brain metastases in patients undergoing combined-modality therapy for stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Four hundred twenty-two eligible, assessable patients with stage IIIA/B NSCLC were treated on four SWOG protocols. Treatment varied with protocol but consisted of concurrent cisplatin-etoposide and radiation in all patients, with a surgery arm in two of the four protocols. Results Of the 422 total patients, 268 (64%) have experienced disease progression; 54 relapses (20%) were in brain only, 17 (6.5%) were in brain and other sites simultaneously, and 197 (63.5%) were in sites other than brain. Of the 268 patients with disease progression, progression in the brain only, in the brain and other sites, and not in the brain occurred in 20%, 6%, and 74% of patients, respectively. Time from treatment to diagnosis of disease progression in the brain in 71 patients was as follows: during treatment, 16 relapses (22.5%); 0 to 16 weeks after treatment, 17 relapses (24%); 16 weeks to 6 months after treatment, 10 relapses (14%); 6 to 12 months after treatment, 16 relapses (22.5%); and more than 12 months after treatment, 12 relapses (17%). Nonsquamous histology and young patient age were the only significant predictors for increased risk of early relapse with brain metastases. CONCLUSION Brain metastases often develop early in the course of treatment for stage IIIA/B NSCLC. The statistical designs of ongoing trials of prophylactic cranial irradiation in stage III NSCLC have taken this into account.
On board data fusion and decision system used for obstacle detection: 2D vision versus 1D sensor fusion (2005)

This paper describes an obstacle detection system based on multi-sensorial data fusion. Classically, a vision system is proposed to solve this problem, but the authors want to test another way by using binary scanning sensors as the basic modality of an incremental fusion system. The authors compute a 2-D representation of the smart vehicle environment by combining basic reconstruction and additional incremental information under the assumption of a co-operative environment between vehicles and infrastructure.
An inexpensive microprocessor‐based lighting control for simulating natural photoenvironments in the laboratory (1985)

Abstract A lighting control system interfaced with the inexpensive VIC‐20 microcomputer is described which can automatically vary light intensity and photoperiod in the laboratory to simulate natural intensity curves throughout the day, and daylengths throughout the changing seasons. Adjustments to compensate for differing latitudes and habitat types are easily accomplished through modifications of the controlling software. The system enables the study of effects of crepuscular lighting and circannual periodicities of physiology and behavior which were previously infeasible. Circuit diagrams, details of construction for simultaneous control of three sets of lights, and a menu‐driven BASIC program for accurately simulating the annual light cycle for any point between the equator and 60 degrees north latitude are presented. The importance of photoenvironment in laboratory studies of physiology and behavior is discussed.
Compression of digital hologram for 3D object using wavelet-bandelets transform (2011)

In the transformation based compression algorithms of digital hologram for three-dimensional object, the balance between compression ratio and normalized root mean square (NRMS) error is always the core of algorithm development. The wavelet transform method is efficient to achieve high compression ratio but NRMS error is also high. In order to solve this issue, we propose a hologram compression method using Wavelet-Bandelets transform. Our simulation and experimental results show that the Wavelet-Bandelets method has a higher compression ratio than Wavelet methods and all the other methods investigated in this paper, while it still maintains low NRMS error.
Phase Relationship between 3C‐ and 6H‐Silicon Carbide at High Pressure and High Temperature (2001)

The phase relationship between 3C‐ and 6H‐SiC is investigated in the pressure range 2.5–6.5 GPa and the temperature range 400°–2500°C, by analyzing recovered samples, using X‐ray diffractometry and Raman‐scattering techniques. The phase transition from 3C‐ to 6H‐SiC occurs at 2200°C and 2.5 GPa. In the pressure range >4.5 GPa, 6H‐SiC transforms to 3C‐SiC at 2500°C, via an intermediate state, as indicated by broadening peaks in the X‐ray diffraction profile. Thermodynamically, 3C‐SiC appears to be the low‐temperature stable form, and the temperature of transition to 6H‐SiC, which is stable at high temperature, appears to increase with pressure.
The effect of circuit topology on radiation-induced latchup (1989)

Topological factors that affect latchup were investigated using test structures fabricated in two different CMOS foundries. The geometry of isolation well contacts was found to have a large effect on photocurrent responses because of the effect of the lateral resistance of the well. Experiments that delayed the application of bias until time periods long after the radiation pulse subsided showed that latchup would still occur, with relatively small increases in the radiation intensity required to induce latchup until the delays exceeded several microseconds. This shows that the fast transition of the radiation pulse is not required to trigger latchup, and it also shows how latchup can occur at high intensities after internal voltages collapse to near zero at short times. Latchup tests of a 64K SRAM (static random-access memory) revealed a latchup window that was caused by the presence of two different internal latchup paths with different radiation triggering levels and holding voltages. Data on this device and several MSI devices show how the power-supply current-surge characteristics can be used to select radiation test levels to minimize interference from latchup windows.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Macromolecular crystallography at synchrotron radiation sources: current status and future developments (2010)

X-ray diffraction with synchrotron radiation (SR) has revealed the atomic structures of numerous biological macromolecules including proteins and protein complexes, nucleic acids and their protein complexes, viruses, membrane proteins and drug targets. The bright SR X-ray beam with its small divergence has made the study of weakly diffracting crystals of large biological molecules possible. The ability to tune the wavelength of the SR beam to the absorption edge of certain elements has allowed anomalous scattering to be exploited for phase determination. We review the developments at synchrotron sources and beamlines from the early days to the present time, and discuss the significance of the results in providing a deeper understanding of the biological function, the design of new therapeutic molecules and time-resolved studies of dynamic events using pump–probe techniques. Radiation damage, a problem with bright X-ray sources, has been partially alleviated by collecting data at low temperature (100 K) but work is ongoing. In the most recent development, free electron laser sources can offer a peak brightness of hard X-rays approximately 10 8 times brighter than that achieved at SR sources. We describe briefly how early experiments at FLASH and Linear Coherent Light Source have shown exciting possibilities for the future.
<p>Prefilled syringes for intravitreal drug delivery</p> (2019)

Intravitreal injections of anti-vascular endothelial growth factor (VEGF) medications play an increasingly critical role in numerous retinal vascular diseases. Initially, anti-VEGF medications came in vials that had to be drawn up by the physician into a syringe for administration. In 2018, the US Food and Drug Administration (US FDA) approved the ranibizumab 0.3 mg prefilled syringe (PFS), and in October 2016, the US FDA approved the ranibizumab 0.5 mg PFS. This article discusses the advantages of the PFS, including reduced injection time, possible reduced risk of endophthalmitis, reduction in intraocular air bubbles and silicone oil droplets, and improved precision in the volume and dose of intravitreal ranibizumab administered, along with possible disadvantages. Implications of the innovation of the PFS on intravitreal injection technique and clinical practice pattern are discussed and reviewed.
Maximizing Security Management Performance and Decisions with the MFC Cyber Security Model: e- learning case study (2017)

The Mean failure Cost (MFC) is a cascade of linear models that quantify security threats by taking into consideration the system’s stakeholders, security requirements, architectural components and threats. This quantitative cyber security model monetizes system’s security in terms of cost which may be lost due to security failure. The lack of quantitative security models in security decision making is a way to discover strengths and uniqueness of the MFC cyber security model. This paper intends to extend this measure into a security risk management model for ultra large systems and to exploit the previously presented MFC model’s characteristics in security decision making relying on a rigorous and quantifiable analysis of financial returns. In fact, we intend to provide a possible solution to security problems using the MFC model in order to set the highest security priorities and choose the suitable countermeasures as well as computing the profitability of the proposed security countermeasures through the Return on Investment (ROI) based on the MFC’s values for each stakeholder. This will lead to monitoring the effectiveness of the proposed security countermeasures, ensuring the best solution choice by saving both time and money and providing a security decision maker with adequate justification to perform his security choice. The practical investigation is to be conducted thought the context of e-learning platforms.
On the Role of Human Chorionic Gonadotropin (hCG) in the Embryo-Endometrial Microenvironment: Implications for Differentiation and Implantation (2001)

Recent evidence suggests that human chorionic gonadotropin (hCG), in addition to its well-known endocrine effects on the corpus luteum, may act as a growth and differentiation factor during pregnancy. According to experimental results, its mode of action may be divided into three sequential phases. During the first phase, which begins at the blastocyst stage and lasts until the occurrence in the serum, hCG acts preferentially in a juxtacrine manner. We have used an intrauterine microdialysis system developed in our laboratory to administer low concentrations of hCG to the endometrium of women in the luteal phase of the menstrual cycle. HCG administration provoked profound effects on paracrine parameters of differentiation (IGFBP-1, prolactin) and implantation (LIF, M-CSF). VEGF, a cytokine important for neoangiogenesis, was significantly stimulated by hCG (P < .01), suggesting a role for hCG in the control of endometrial vascularization and placentation. The investigation of endometrial parameters of tissue remodeling revealed a significant increase of MMP-9 (P < .05) but not of TIMP-1 following hCG infusion. The second, endocrine, phase of hCG action is marked by the appearance of hCG in the maternal serum. Rising systemic hCG levels cause a very rapid elevation of serum progesterone reflecting the rescue of the corpus luteum. Other endocrine functions of hCG include its intrinsic thyrotropic activity as well as modulation of fetal testicular, ovarian, and adrenal function. The third phase may be characterized by the expression of full-length hCG/LH receptors on the trophoblasts themselves. Before the ninth week of gestation, human villous trophoblasts express a truncated hCG/LH receptor isoform (50 kDa) and are probably not responsive to hCG. Later, the expression pattern is switched to the full-length receptor (80 kDa), allowing hCG also to modulate the differentiation of the trophoblasts themselves. A special feature is the self-regulation of hCG biosynthesis that may in part explain the unique secretion profile of the hormone with peak levels during the first trimester followed by a rapid decline after the tenth week of gestation. In summary, hCG seems to have a variety of local and systemic functions in and outside the embryo-endometrial microenvironment.
Jogging and Coronary Heart Disease (1974)

We very much appreciate Dr. Chatterjee's response to our article and confess that we overlooked his previously published data when reviewing the medical literature for our own manuscript.The average values for the mean nor- malized systolic ejection rate in his normal and cardiomyopathy groups are remarkably similar to the values in our patients with normal and depressed ventricular func- tion, respectively.It is of interest that the values he derived from single plane cineangiograms are in close accord with those which we calculated from biplane studies.It should be noted, however, that our methodology is somewhat different; we estimate the ejection time from the cine fram- ing rate assuming an arbitrary 50 millisecond duration for the preejection period, whereas Chatterjee derived the ejec- tion rate by "drawing a tangent on the ejection portion of the volume curve."'Dr. Chatterjee's data, we believe, further validate the use of ejection phase indices, and in par- ticular the mean normalized systolic ejection rate, to assess myocardial performance in man.
Improvement of JC Properties through Control of Nanorod Morphology (2013)

BaHfO3 nanorod doped SmBa2Cu3Oy films were deposited on LaAlO3 (001) substrates using pulsed-laser deposition (PLD). An alternating target (ALT) technique was used as the BaHfO3 supply method. Two films were grown at 910 and 830ºC using a conventional PLD technique. One film was grown at 750ºC (an upper layer) on a seed layer using a low temperature growth (LTG) technique. Nanorod morphologies were analyzed using a scanning transmission electron microscopy (STEM) with an energy dispersive X-ray spectroscopy. It was found that the nanorod morphology varied by changing the growth temperature and the underlying structure. It was found that the critical current properties qualitatively corresponded to the nanorod morphology. In the case of straight, continuous nanorods, a magnetic field for the maximum value of global pinning force and the matching field estimated by a plan-view STEM analysis were consistent. We discussed the parameters for the control of nanorod morphology including the growth temperature and the underlying structure which were confirmed as the parameters in this experiment.
Swelling studies of copolymeric acrylamide/crotonic acid hydrogels as carriers for agricultural uses (2000)

In this study, highly swollen acrylamide/crotonic acid hydrogels (in a rod form) containing some inorganic salts such as ammonium nitrate, potassium nitrate and ammonium sulphate used as fertilizer, an agricultural drug such as Dalapon (sodium 2,2-dichloropropionate) and two crosslinkers such as ethylene glycol dimethacrylate and 1,4-butandiol dimethacrylate were prepared by copolymerization of acrylamide and crotonic acid with γ-radiation. As a result of swelling tests, the influence of γ-ray dose and relative content of crotonic acid on the swelling properties, the diffusional behavior of water, diffusion coefficients and network properties of the hydrogel systems were examined. Acrylamide/crotonic acid hydrogels containing these salts and agricultural drug were swollen in the range 2045–400% in water, while polyacrylamide hydrogels swelled in the range 660–700%. Water intake of hydrogels followed a nonFickian-type diffusion. Copyright © 2000 John Wiley & Sons, Ltd.
Toward the Mastery of Resiliency (2008)

This article provides an analysis on the articles published in this special issue focusing on resiliency. A synthesis of these articles, arguing for the importance of resiliency in promoting psychological well-being, is presented in the commentary section.
Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice. (1992)

The preproenkephalin A gene is a neurotransmitter gene whose expression can be modulated "trans-synaptically" by changes in neuronal activity. DNA sequences lying within 200 base pairs of this gene's transcription start site resemble consensus binding sites for several transcription factor families. In nonneuronal cell cultures, this promoter region is sufficient to mediate gene responses to depolarization, phorbol esters, adenylate cyclase, and calcium fluxes. To assess the role that these cis-acting elements could play in preproenkephalin expression and regulation in vivo, the expression of a construct containing this 200-base-pair region fused to the chloramphenicol acetyltransferase gene was examined in transgenic mice. This promoter confers modest expression in brain, adrenal, and small intestine, with substantially higher levels in testis. These elements confer trans-synaptic regulation in two well-studied models of trans-synaptic preproenkephalin upregulation but not in a third system, underscoring the specificity of the regulatory sequence elements implicated in the synaptic regulation of neuronal genes.
Model Systems for Examining Effects of Leukemia Associated Oncogenes in Primary Human CD34+ Cells via Retroviral Transduction (2009)

The use of primary human cells to model cancer initiation and progression is now within the grasp of investigators. It has been nearly a decade since the first defined genetic elements were introduced into primary human epithelial and fibroblast cells to model oncogenesis. This approach has now been extended to the hematopoietic system, with the first described experimental transformation of primary human hematopoietic cells. Human cell model systems will lead to a better understanding of the species and cell type specific signals necessary for oncogenic initiation and progression, and will allow investigators to interrogate the cancer stem cell hypothesis using a well-defined hierarchical system that has been studied for decades. The molecular and biochemical link between self-renewal and differentiation can now be experimentally approached using primary human cells. In addition, the models that result from these experiments are likely to generate highly relevant systems for use in identification and validation of potential therapeutic targets as well as testing of small molecule therapeutics. We describe here the methodologies and reagents that are used to examine the effects of leukemia fusion protein expression on primary human hematopoietic cells, both in vitro and in vivo.
Squalene content and neutral lipis composition of Livers from Deep-sea sharks caught in Tasmanian waters (1990)

Deep-sea sharks (mainly dogfish) are a significant by-catch of trawls for the deep-water fish orange roughy (Hoplostethus atlanticus). To test whether the livers of these sharks might be a source of commerically valuable squalene and other lipids, 16 sharks of 8 species were collected from Tasmanian waters at depths of 700-1200 m during research cruise S02/88 of FRV Soela. The sharks were Centroscyrnnus crepidater (longnose velvet dogfish), Centroscyrnnus owstoni (Owston's dogfish), Centroscyrnnus coelolepis (Portuguese dogfish), Deania calcea (shovelnose dogfish), Etmopterus baxteri (Baxter's dogfish), Etmopterus sp. nov. (unnamed dwarf dogfish), Dalatias licha (kitefin or seal shark) and Centrophorus squarnosus (leafscale gulper shark). Squalene content, triacylglycerols, diacylglyceryl ethers, total fatty acids, pristane and other lipids were analysed by capillary gas chromatography and thin-layer chromatography-flame ionization detection. The livers contained high levels of squalene (15-69% by weight), except for the liver of C. squarnosus (I%), which had an unusually high amount of diacylglyceryl ethers (79%). Triacylglycerol and diacylglyceryl ether contents in the livers ranged from 1 to 26% and from 7 to 79% by weight respectively. The C19 isoprenoid alkane pristane was a minor constituent in all samples (0.01-0.56% by weight of liver). The three major esterified fatty acids in all samples were palmitic (16:0), oleic [18: 1 (n - 9)] and eicosa-11-enoic [20: 1 (n - 9)] fatty acids. Polyunsaturated fatty acids were minor constituents. These data indicate that shark livers could provide a profitable by-catch from deep-water trawls, but it is unlikely that shark could form the basis for a target fishery due to their susceptibility to overfishing.
Melodic Similarity: Looking For A Good Abstraction Level. (2004)

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