gebhart/patrepeval huggingface dataset:
Studies on the Structure of the G-Protein-Coupled Receptor Rhodopsin Including the Putative G-Protein Binding Site in Unactivated and Activated Forms (2001)

Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.
Transmission Corridor Location Modeling (1985)

The location of corridor rights‐of‐way has been approached by a number of investigators dealing with problems of transmission power lines, pipelines, highways, and other transport systems. A commonly used three step approach in computerized approaches for locating a transmission corridor is reviewed. This three step methodology is widely accepted and employed in virtually all computerized corridor models. Unfortunately there can be significant geometric errors in the actual application of these techniques due to the underlying network representation. The sources of error are discussed and an approach is presented that can measurably reduce such errors. Applications to a hypothetical data set and to a statewide geo‐based inforniation system data base are presented.
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy (2017)

The median overall survival for children with diffuse intrinsic pontine glioma (DIPG) is less than one year. The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3.3). From a CD8<sup>+</sup> T cell clone established by stimulation of HLA-A2<sup>+</sup> CD8<sup>+</sup> T cells with synthetic peptide encompassing the H3.3K27M mutation, complementary DNA for T cell receptor (TCR) α- and β-chains were cloned into a retroviral vector. TCR-transduced HLA-A2<sup>+</sup> T cells efficiently killed HLA-A2<sup>+</sup>H3.3K27M<sup>+</sup> glioma cells in an antigen- and HLA-specific manner. Adoptive transfer of TCR-transduced T cells significantly suppressed the progression of glioma xenografts in mice. Alanine-scanning assays suggested the absence of known human proteins sharing the key amino acid residues required for recognition by the TCR, suggesting that the TCR could be safely used in patients. These data provide us with a strong basis for developing T cell-based therapy targeting this shared neoepitope.
Organic Vapor Sensing with Ionic Liquids Entrapped in Alumina Nanopores on Quartz Crystal Resonators (2004)

We report on a concept for vapor sensing with the quartz crystal microbalance where the vapor phase is absorbed into small droplets of an ionic liquid. The liquid is contained in the pores of a nanoporous alumina layer, created on the front electrode of the quartz crystal by anodization. Ionic liquids are attractive for vapor sensing because--being liquids--they equilibrate very fast, while at the same time having negligible vapor pressure. Containing the ionic liquids inside cylindrical cavities of a solid matrix removes all problems related to the liquid's softness as well as the possibility of dewetting and flow. The absence of viscoelastic effects is evidenced by the fact that the bandwidth of the resonance remains unchanged during the uptake of solvent vapor. The Henry constants for a number of solvents have been measured.
Voice based Internet Browser (2013)

Websites are accessible only through devices equipped with a screen and a Graphical User Interface (GUI).This requires physical interaction with devices. We present a system which allows browsing the Internet by using a standard voice only, with the development of a Vocal User Interface (VUI). The system accepts vocal commands as input from the user, translates those commands into HTTP requests, sends them to the web server which processes it and finally returns the HTTP response translated back to the user in a vocally manner. To reach this goal the system implements Content Extraction (CE) algorithms over web content in order to analyze, classify and return relevant parts of web pages to the user. The Microsoft speech SDK allows applets transmitted over the Internet or intranets to access speech capabilities on the user's machine. This provides the ability to enhance World Wide Web sites with speech and support new ways of browsing. Speech recognition can be used to control browsers, fill out forms, control applets and enhance the WWW/Internet experience in many other ways. Speech synthesis can be used to bring web pages alive, inform users of the progress of applets, and dramatically improve browsing time by reducing the amount of audio sent across the Internet. Its applications are numerous: for example helping the blind access the internet through speech and hearing, helping disabled people or young children unable to use a keyboard to “speak” their commands into the web, or, simply enabling any person to interface the web contents via oral commands, instead of a keyboard. Keyword: Content extraction, Voice reorganization
Call Me Back! (2016)

Android is the most commonly used mobile device operation system. The core of Android, the System Server (SS), is a multi-threaded process that provides most of the system services. Based on a new understanding of the security risks introduced by the callback mechanism in system services, we have discovered a general type of design flaw. A vulnerability detection tool has been designed and implemented based on static taint analysis. We applied the tool on all the 80 system services in the SS of Android 5.1.0. With its help, we have discovered six previously unknown vulnerabilities, which are further confirmed on Android 2.3.7-6.0.1. According to our analysis, about 97.3% of the entire 1.4 billion real-world Android devices are vulnerable. Our proof-of-concept attack proves that the vulnerabilities can enable a malicious app to freeze critical system functionalities or soft-reboot the system immediately. It is a neat type of denial-of-service at-tack. We also proved that the attacks can be conducted at mission critical moments to achieve meaningful goals, such as anti anti-virus, anti process-killer, hindering app updates or system patching. After being informed, Google confirmed our findings promptly. Several suggestions on how to use callbacks safely are also proposed to Google.
Prevention of meningococcal disease (1998)

Meningococcal infections are an important health care problem in underdeveloped areas, and their incidence is growing in developed countries. Despite the great advances in the treatment of bacterial infections, mortality due to meningitis and meningococcaemia is high, about 10%, morbidity also being important. Meningococcal diseases can be prevented in close contacts of cases by using chemoprophylaxis, to eliminate the carrier state, or vaccination. Those vaccines which are actually approved are made from purified capsular polysaccharides and are effective only for meningococcal serogroups A and C (also Y and W135 in some cases), but they present some important problems - particularly their ineffectivity in children under 2 years and their inability to induce immunological memory. The most promising alternatives are the vaccines based on outer membrane proteins; these vaccines can induce memory, can be effective at all ages and can act against all serogroups, particularly serogroup B, the serogroup which causes most of the cases in developed countries.
Multiframe error concealment for MPEG-coded video delivery over error-prone networks (2002)

Compressed video sequences are very vulnerable to channel disturbances when they are transmitted through an unreliable medium such as a wireless channel. Transmission errors not only corrupt the current decoded frame, but they may also propagate to succeeding frames. A number of post-processing error concealment (ECN) methods that exploit the spatial and/or temporal redundancy in the video signal have been proposed to combat channel disturbances. Although these approaches can effectively conceal lost or erroneous macroblocks (MBs), all of them only consider spatial and/or temporal correlation in a single frame (the corrupted one), which limits their ability to obtain an optimal recovery. Since the error propagates to the next few motion-compensated frames in the presence of lost MBs in an I or P frame, error concealment should simultaneously minimize the errors not only in the current decoded frame but also in the succeeding B and P frames that depend on the corrupted frame. We propose a novel multiframe recovery principle which analyzes the propagation of a lost MB into succeeding frames. Then, MPEG-compatible spatial and temporal error concealment approaches using this multiframe recovery principle are proposed, where the lost MBs are recovered in such a way that the error propagation is minimized.
IL-12 induces T helper 1-directed antitumor response (1997)

Although IL-12 possesses the most potent single-cytokine antitumor efficacy, the mechanism by which IL-12 exerts its antitumor activities remains unclear. Using a complete tumor regression model induced by IL-12 treatment, we demonstrate that the antitumor response induced by IL-12 is mediated by a Th1 cell-directed process, with the macrophage as the effector cell and nitric oxide produced by the activated macrophage as the effector molecule. The induction of the Th1 response by IL-12 depends on the existence of a host T cell response to the tumor before IL-12 administration. IL-12 treatment causes the complete regression of 10-day established s.c. tumors (4-8 mm). Associated with the induction of tumor necrosis, activated macrophages expressing high levels of inducible nitric oxide synthase were found surrounding the tumor. The importance of nitric oxide as the effector molecule was further confirmed by the delay and loss of tumor regression in the presence of a nitric oxide synthase inhibitor in vivo. Examination of tumor-associated T cells indicates that IL-12 induces production of the Th1 cytokine IFN-gamma and suppresses production of IL-2, IL-4, and IL-10 at the tumor site, where these are found to be the predominant cytokines produced by tumor-associated T cells before IL-12 treatment. These findings demonstrate that IL-12 plays an essential role in the induction of an effective Th1 type of cell-mediated immune response against established tumors.
On HTLC-Based Protocols for Multi-Party Cross-Chain Swaps (2024)

In his 2018 paper, Herlihy introduced an atomic protocol for multi-party asset swaps across different blockchains. Practical implementation of this protocol is hampered by its intricacy and computational complexity, as it relies on elaborate smart contracts for asset transfers, and specifying the protocol’s steps on a given digraph requires solving an NP-hard problem of computing longest paths. Herlihy left open the question whether there is a simple and efficient protocol for cross-chain asset swaps in arbitrary digraphs. Addressing this, we study HTLC-based protocols, in which all asset transfers are implemented with standard hashed time-lock smart contracts (HTLCs). Our main contribution is a full characterization of swap digraphs that have such protocols, in terms of so-called reuniclus graphs. We give an atomic HTLC-based protocol for reuniclus graphs. Our protocol is simple and efficient. We then prove that non-reuniclus graphs do not have atomic HTLC-based swap protocols.
Measurements of acute cerebral infarction: a clinical examination scale. (1989)

We designed a 15-item neurologic examination stroke scale for use in acute stroke therapy trials. In a study of 24 stroke patients, interrater reliability for the scale was found to be high (mean kappa = 0.69), and test-retest reliability was also high (mean kappa = 0.66-0.77). Test-retest reliability did not differ significantly among a neurologist, a neurology house officer, a neurology nurse, or an emergency department nurse. The stroke scale validity was assessed by comparing the scale scores obtained prospectively on 65 acute stroke patients to the patients' infarction size as measured by computed tomography scan at 1 week and to the patients' clinical outcome as determined at 3 months. These correlations (scale-lesion size r = 0.68, scale-outcome r = 0.79) suggested acceptable examination and scale validity. Of the 15 test items, the most interrater reliable item (pupillary response) had low validity. Less reliable items such as upper or lower extremity motor function were more valid. We discuss methods for improving the reliability and validity of brief examination scales to be used in stroke therapy trials.
Identification of the <i>Escherichia coli</i> K-12 <i>ybhE</i> Gene as <i>pgl</i> , Encoding 6-Phosphogluconolactonase (2004)

We report identification of the Escherichia coli ybhE gene as the pgl gene that encodes 6-phosphogluconolactonase. A tentative identification was first made based on the known approximate location of the pgl gene and the similarity of the presumptive ybhE-encoded protein sequence to a known Pgl enzyme. To test this notion, the ybhE gene was deleted and replaced with a drug marker. Like previously characterized pgl mutants, the ybhE deletion mutant had a Blu- phenotype (dark-blue staining with iodine due to accumulation of starch after growth on minimal maltose) and demonstrated impaired growth on minimal glucose medium when combined with a pgi mutation. Biochemical assay of crude extracts for 6-phosphogluconolactonase enzymatic activity showed that ybhE encodes this activity. The ybhE gene was transferred from the E. coli chromosome to an expression vector. This ybhE clone complemented both the precise deletion of the ybhE gene and a larger deletion, pglDelta8, for the Blu- phenotype and for phosphogluconolactonase activity, confirming that ybhE is the pgl gene. A newly observed phenotype of pgl strains is a lowered frequency of appearance of Bgl+ mutants that can utilize the beta-glucoside salicin. This is likely due to poor growth of Bgl+ pgl strains on salicin due to the accumulation of 6-phosphogluconolactone.
Olefinic-Lactone Cyclizations to Macrocycles (2008)

Olefinic-lactone cyclization reactions that result in the generation of macrocycles are described.
P‐171: High‐Efficiency Low‐Voltage Phosphorescent OLED Devices with Mixed Host (2007)

Abstract We demonstrate high‐efficiency, low‐voltage phosphorescent OLED devices (PHOLEDs) using mixed host materials in the light‐emitting layer (LEL) and novel formulations in the electrontransporting/ electron‐injecting layers (ETL/EIL). The LEL architecture offers significant improvement in efficiency and voltage compared to conventional phosphorescent OLEDs with carbazole‐based hosts. Further voltage reduction in our PHOLEDs is achieved through use of a novel material formulation in the ETL and EIL.
[Central serotonin administration and post-stress damage of the gastric mucosa in inbred mice during various seasons]. (1989)

The severity of neurogenic damage to the gastric mucosa (GM) induced by emotional stress (ES) in administration of serotonin or its precursor in biosynthesis--5-hydroxytryptophan into the lateral ventricle of the brain was studied in experiments on mice of inbred strains. The development of lesions in the GM in the form of erosions and hemorrhages proved to be dependent on many factors, first of all on the time of administration of the preparations--before or after ES. The effect of 5-hydroxytryptophan on the formation of GM stress damage was less marked than that of serotonin. The intensifying effect of exogenous serotonin on post-stress GM damage was mainly manifested in the spring, which is associated with ES induced activation of the brain serotonergic system. The effect of exogenous serotonin on the degree of the neurogenous damage to the GM caused by ES is determined to a great measure by the genotype differences in the sensitivity of the central serotonergic mechanisms to the stimulating effect.
Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog (2011)

The capsaicin receptor TRPV1 is the principal transduction channel for nociception. Excessive TRPV1 activation causes pathological pain. Ideal pain mangement requires selective inhibition of hyperactive pain-sensing neurons, but sparing normal nociception. We sought to determine whether it is possible to use activity-dependent TRPV1 agonists to identify nerves with excessive TRPV1 activity, as well as exploit the TRPV1 pore to deliver charged anesthetics for neuronal silencing. We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents. Cap-ET-induced YO-PRO-1 transport required permeation of both the agonist and the dye through the TRPV1 pore and could be enhanced by kinase activation or oxidative covalent modification. Moreover, cap-ET reduced capsaicin-induced currents by a voltage-dependent block of the pore. A low dose of cap-ET elicited entry of permanently charged Na(+) channel blockers to effectively suppress Na(+) currents in sensory neurons presensitized with oxidative chemicals. These results implicate therapeutic potential of these unique TRPV1 agonists exhibiting activity-dependent ion transport but of minimal pain-producing risks.
Web search garage (2004)

Best-selling author and research expert Tara Calishain offers her insider tips and tricks for web searching in this title from Prentice Hall PTR's Garage Series. The book begins with an in-depth look at search engines and other online tools such as browsers. It describes several principles of web searching to help you leverage the scope of the Internet to discover information. The book also covers specific topic areas of Internet searching, both domestically and internationally. Finally, Web Search Garage includes a special technical support section to teach you how to find the support solutions you need on the Internet.Specific topics covered include Search engines Browsers The principles of web searching Searching for news, jobs, and local information Finding images and audio on the web Searching for people Genealogy research Consumer help Drugs and medical information Kid-safe searchingWhether you're a newbie or an Internet search guru, Web Search Garage is a valuable resource for using the Internet wisely to find the information you're looking for. Calishain's thorough explanations and examples, combined with her entertaining wit will help you fine-tune your skills and search the Internet to find convenient solutions.
Non-Linear Learning Factor Control for Statistical Adaptive Background Subtraction Algorithm (2005)

The background subtraction algorithm has been proven to be a very effective technique for automated video surveillance applications. In statistical approach, background model is usually estimated using Gaussian model and is adaptively updated to deal with changes in dynamic scene environment. However, most algorithms update background parameters linearly. As a result, the classification results are erroneous when performing background convergence process. In this paper, we present a novel learning factor control for adaptive background subtraction algorithm. The method adaptively adjusts the rate of adaptation in background model corresponding to events in video sequence. Experimental results show the algorithm improves classification accuracy compared to other known methods.
Real-time virtual humans (2002)

The last few years have seen great maturation in the computation speed and control methods needed to portray 3D virtual humans that are suitable for real interactive applications. We first describe the state of the art, then focus on the particular approach taken at the University of Pennsylvania with the Jack system. Various aspects of real-time virtual humans are considered, such as their appearance and motion, interactive control, autonomous actions, gestures, attention, locomotion and multiple individuals. The underlying architecture consists of a sense-control-act structure that permits reactive behaviors to be locally adaptive to the environment, and a PaT-Net (parallel transition network) parallel-finite-state machine controller that can be used to drive virtual humans through complex tasks. We then argue for a deep connection between language and animation and describe current efforts in linking them through two systems: the Jack Presenter and the JackMOO extension to lambdaMOO. Finally, we outline a parameterized action representation for mediating between language instructions and animated actions.
Maculate conceptions (1987)

Margaret Homans: Bearing the Word: Languaye and Female Experience in Nineteenth‐Century Women's Writing. (University of Chicago Press) Chicago and London, 1986.
Fault tolerant parallel processor architecture overview (2003)

The authors address issues central to the design and operation of a Byzantine resilient parallel computer. Interprocessor connectivity requirements are met by treating connectivity as a resource which is shared among many processing elements, allowing flexibility in their configuration and reducing complexity. Reliability analysis results are presented which demonstrate the reduced failure probability of such a system. Redundant groups are synchronized solely by message transmissions and receptions, which also provide input data consistency and output voting. Performance analysis results are presented which quantify the temporal overhead involved in executing such fault tolerance-specific operations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
3.0 W blue light generation by frequency doubling of broad area semiconductor amplifier emission (1993)

Broad area GaAlAs amplifier emission is frequency doubled in a single pass through a 2 cm long KNbO3 crystal. A maximum peak power of 3.0 W at 432 nm is achieved with 15.6 W of incident fundamental power and 0.3 μs long pulses, corresponding to a 190% nonlinear conversion efficiency.
Development of a recombinase-aided amplification assay for rapid detection of human norovirus GII.4 (2021)

This RT-RAA assay provides a rapid, specific, and sensitive assay for human norovirus detection and is suitable for clinical testing.