gebhart/patrepeval huggingface dataset:
Stimulus-Dependent Regulation of Nuclear Ca2+ Signaling in Cardiomyocytes: A Role of Neuronal Calcium Sensor-1 (2015)

In cardiomyocytes, intracellular calcium (Ca2+) transients are elicited by electrical and receptor stimulations, leading to muscle contraction and gene expression, respectively. Although such elevations of Ca2+levels ([Ca2+]) also occur in the nucleus, the precise mechanism of nuclear [Ca2+] regulation during different kinds of stimuli, and its relationship with cytoplasmic [Ca2+] regulation are not fully understood. To address these issues, we used a new region-specific fluorescent protein-based Ca2+ indicator, GECO, together with the conventional probe Fluo-4 AM. We confirmed that nuclear Ca2+ transients were elicited by both electrical and receptor stimulations in neonatal mouse ventricular myocytes. Kinetic analysis revealed that electrical stimulation-elicited nuclear Ca2+ transients are slower than cytoplasmic Ca2+ transients, and chelating cytoplasmic Ca2+ abolished nuclear Ca2+ transients, suggesting that nuclear Ca2+ are mainly derived from the cytoplasm during electrical stimulation. On the other hand, receptor stimulation such as with insulin-like growth factor-1 (IGF-1) preferentially increased nuclear [Ca2+] compared to cytoplasmic [Ca2+]. Experiments using inhibitors revealed that electrical and receptor stimulation-elicited Ca2+ transients were mainly mediated by ryanodine receptors and inositol 1,4,5-trisphosphate receptors (IP3Rs), respectively, suggesting different mechanisms for the two signals. Furthermore, IGF-1-elicited nuclear Ca2+ transient amplitude was significantly lower in myocytes lacking neuronal Ca2+ sensor-1 (NCS-1), a Ca2+ binding protein implicated in IP3R-mediated pathway in the heart. Moreover, IGF-1 strengthened the interaction between NCS-1 and IP3R. These results suggest a novel mechanism for receptor stimulation-induced nuclear [Ca2+] regulation mediated by IP3R and NCS-1 that may further fine-tune cardiac Ca2+ signal regulation.
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides (2015)

The transient receptor potential (TRP) channel TRPM3 is a calcium-permeable cation channel activated by heat and by the neurosteroid pregnenolone sulfate (PregS). TRPM3 is highly expressed in sensory neurons, where it plays a key role in heat sensing and inflammatory hyperalgesia, and in pancreatic β cells, where its activation enhances glucose-induced insulin release. However, despite its functional importance, little is known about the cellular mechanisms that regulate TRPM3 activity. Here, we provide evidence for a dynamic regulation of TRPM3 by membrane phosphatidylinositol phosphates (PIPs). Phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2) and ATP applied to the intracellular side of excised membrane patches promote recovery of TRPM3 from desensitization. The stimulatory effect of cytosolic ATP on TRPM3 reflects activation of phosphatidylinositol kinases (PI-Ks), leading to resynthesis of PIPs in the plasma membrane. Various PIPs directly enhance TRPM3 activity in cell-free inside-out patches, with a potency order PI(3,4,5)P3 > PI(3,5)P2 > PI(4,5)P2 ≈ PI(3,4)P2 >> PI(4)P. Conversely, TRPM3 activity is rapidly and reversibly inhibited by activation of phosphatases that remove the 5-phosphate from PIPs. Finally, we show that recombinant TRPM3, as well as the endogenous TRPM3 in insuloma cells, is rapidly and reversibly inhibited by activation of phospholipase C-coupled muscarinic acetylcholine receptors. Our results reveal basic cellular mechanisms whereby membrane receptors can regulate TRPM3 activity.
Ischaemic colitis and the contraceptive pill. (1971)

which classes of hyperlipoproteinaemia are best treated with a combination or with clofibrate alone. It is, however, quite clear that its greatest potential use is for the treatment of the type II pattern, which is, in general, affected little by clofibrate alone and only moderately by cholestyramine.
MANAGING ROADWAY SNOW AND ICE CONTROL OPERATIONS (1994)

This synthesis report will be of interest to transportation agency maintenance engineers, managers, and operators and others involved with roadway snow and ice control including safety engineers, traffic engineers, and law enforcement agency personnel. It presents information on the state of the practice in managing roadway snow and ice control considering both rural and urban locations. The document describes the developments that have occurred during the past 20 years to improve winter maintenance. This report of the Transportation Research Board discusses winter maintenance policies and provides examples for state, city, and county agencies. Included in the discussion of winter maintenance policies are issues such as: levels of service, public relations, liability for services, and experimenting with new policies. Additional information is included on estimating winter maintenance benefits and costs; personnel and management issues; weather information systems; and materials, equipment, and facilities for winter maintenance.
Chronobiological aspects of the mammalian pineal gland. (1981)

Pineal melatonin production is highly cyclic and depends on alternating periods of light and darkness. Peak melatonin synthesis occurs during the dark phase of the light: dark cycle. Interruption of the sympathetic nerve supply to the pineal gland, exposure of the animals to continuous light, or the administration of a beta-adenergic antagonist obliterates the daily rise in pineal melatonin levels. At least in hamsters, circulating gonadal steroids seem to have minimal influence on the circadian rhythm in melatonin production.
Management of the Brown Recluse Spider Bite (1981)

Rees, Riley M.D.; Shack, R Bruce M.D.; Withers, Edward M.D.; Madden, James M.D.; Franklin, John M.D.; Lynch, J B M.D. Author Information
Developments in New Optical Materials (1986)

This paper is a review of current developments in new optical materials based on a survey of the recent literature. Rapid advances are taking place in the fields of passive and active optical materials. Among the former are new optical fibers and refractive materials suitable for excimer lasers. Among the latter are electrooptic crystals of many varieties including liquid crystals and molecular non-linear materials. Among the key application areas are optical fibers waveguides, optical storage, and optical data processing devices. Several examples of each of these new areas will be mentioned in the paper.
ChemInform Abstract: BaCo2Si2O7: A New One‐Dimensional Antiferromagnet Based on Chains of Oxide Bridged CoO4 Tetrahedra. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An Ultrasonic Transducer Interface IC With Integrated Push-Pull 40 Vpp, 400 mA Current Output, 8-bit DAC and Integrated HV Multiplexer (2011)

We present an ultrasonic transducer interface IC that includes an 8-bit, 40 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pp</sub> , 400 mA current output DAC for arbitrary waveform transducer excitation and a ±25 V analog multiplexer. The IC was fabricated using a 0.35 μm, 50 V CMOS process. The design eliminates the need for an external power amplifier as the piezoelectric transducer is driven directly from a segmented push-pull current output DAC, which simplifies the overall system design. This approach has the advantage of simple and rapid glitch-free power-up/down, which is especially important in integrated high-output-power drivers. The DAC has been evaluated when operating at a 150 MHz sampling rate with a ±400 mA output current and a 50 Ω load. Measured performance includes 37 dB SNDR and 46 dB SFDR at 10 MHz output frequency. By implementing an additional reference DAC and extending the receiver isolation switch into an analog multiplexer, we enable on-line calibration for the purpose of reducing the driver and receiver signal path uncertainty. Measurements show a greater than ten-fold improvement in delay uncertainty to approximately 20 ps for temperature variations of 0 to 70 degrees Celsius.
Crystallographic Structures and Parasitic Resistances of Self-Aligned Silicide TiSi<sub>2</sub>/Self-Aligned Nitrided Barrier Layer/Selective Chemical Vapor Deposited Aluminum in Fully Self-Aligned Metallization Metal Oxide Semiconductor Field-Effect Transistor (1999)

In deep submicron metal oxide semiconductor field-effect transistor (MOSFET) structures, parasitic resistances of source/drain and gate (S/D&G) regions limit device performance. For the reduction of parasitic resistances, we have previously proposed a fully self-aligned metallization (FSAM) MOSFET using selective aluminum chemical vapor deposition (Al CVD) technology. The features of FSAM-MOSFET are (1) self-aligned silicide (SALICIDE) for low TiSi 2 /n + -Si contact resistances in S/D regions, (2) self-aligned barrier layer on TiSi 2 surface, and (3) selective Al deposition on S/D&G regions for low sheet resistances. In this study, crystallographic structures and parasitic resistances of SALICIDE TiSi 2 /self-aligned nitrided barrier layer/selective CVD Al structures have been investigated. It has been experimentally confirmed that (1) C49-TiSi 2 /n + -Si has lower contact resistance than C54-TiSi 2 /n + -Si, (2) the 10 nm amorphous Ti–Si–N barrier layer has stable thermal endurance and does not increase the contact resistances, and (3) the selective CVD Al layer reduces the sheet resistances of the S/D. Therefore, the combination of SALICIDE TiSi 2 , self-aligned barrier layer and selective CVD Al is promising for the low-temperature FSAM-MOSFET process.
1.5-GHz voltage controlled oscillator with 3% tuning bandwidth using a two-pole DSBAR filter (2011)

First results on a novel voltage controlled oscillator (VCO) in the lower gigahertz range, featuring excellent phase noise and high power efficiency are presented. The heart of the VCO is a recently reported novel miniature two-pole decoupled stacked bulk acoustic resonator (DSBAR) filter. With its single 180° phase transition over the 1 dB bandwidth, linear phase, and maximum 1 dB insertion loss, it provides stable single-mode operation over 45 MHz (≈3%) of tuning bandwidth and has negligible heat dissipation when operated at incident power levels of 100 mW or greater. The 1.55-GHz laboratory VCO prototypes operate at 5 V supply voltage, 50 mA supply current, 15 dBm of output power, and >13% efficiency, demonstrating -84 and < -180 dBc/Hz phase noise suppression at 1 kHz carrier offset and in the thermal noise region, respectively. VCOs with cascaded DSBAR filters for further phase noise reduction are also demonstrated.
Wearable Physiological Sensors Reflect Mental Stress State in Office-Like Situations (2013)

Timely mental stress detection can help to prevent stress-related health problems. The aim of this study was to identify those physiological signals and features suitable for detecting mental stress in office-like situations. Electrocardiogram (ECG), respiration, skin conductance and surface electromyogram (sEMG) of the upper trapezius muscle were measured with a wearable system during three distinctive stress tests. The protocol contained stress tests that were designed to represent office-like situations. Generalized Estimating Equations were used to classify the data into rest and stress conditions. We reached an average classification rate of 74.5%. This approach may be used for continuous stress measurement in daily office life to detect mental stress at an early stage.
Equine subepithelial keratomycosis (2012)

This is the first clinical report of a subtle form of keratomycosis in the horse. Subepithelial keratomycosis may be a distinct clinical entity or represent a continuum in the described forms of equine keratomycosis.
Novel Flexible Transparent Conductive Films with Enhanced Chemical and Electromechanical Sustainability: TiO<sub>2</sub> Nanosheet–Ag Nanowire Hybrid (2017)

Flexible transparent conductive films (TCFs) of TiO<sub>2</sub> nanosheet (TiO<sub>2</sub> NS) and silver nanowire (Ag NW) network hybrid were prepared through a simple and scalable solution-based process. The as-formed TiO<sub>2</sub> NS-Ag NW hybrid TCF shows a high optical transmittance (TT: 97% (90.2% including plastic substrate)) and low sheet resistance (R<sub>s</sub>: 40 Ω/sq). In addition, the TiO<sub>2</sub> NS-Ag NW hybrid TCF exhibits a long-time chemical/aging and electromechanical stability. As for the chemical/aging stability, the hybrid TCF of Ag NW and TiO<sub>2</sub> NS reveals a retained initial conductivity (ΔR<sub>s</sub>/R<sub>s</sub> < 1%) under ambient oxidant gas over a month, superior to that of bare Ag NW (ΔR<sub>s</sub>/R<sub>s</sub> > 4000%) or RuO<sub>2</sub> NS-Ag NW hybrid (ΔR<sub>s</sub>/R<sub>s</sub> > 200%). As corroborated by the density functional theory simulation, the superb chemical stability of TiO<sub>2</sub> NS-Ag NW hybrid is attributable to the unique role of TiO<sub>2</sub> NS as a barrier, which prevents Ag NW's chemical corrosion via the attenuated adsorption of sulfidation molecules (H<sub>2</sub>S) on TiO<sub>2</sub> NS. With respect to the electromechanical stability, in contrast to Ag NWs (ΔR/R<sub>0</sub> ∼ 152.9%), our hybrid TCF shows a limited increment of fractional resistivity (ΔR/R<sub>0</sub> ∼ 14.4%) after 200 000 cycles of the 1R bending test (strain: 6.7%) owing to mechanically welded Ag NW networks by TiO<sub>2</sub> NS. Overall, our unique hybrid of TiO<sub>2</sub> NS and Ag NW exhibits excellent electrical/optical properties and reliable chemical/electromechanical stabilities.
Bayesian correlated clustering to integrate multiple datasets (2012)

Using a set of six artificially constructed time series datasets, we show that MDI is able to integrate a significant number of datasets simultaneously, and that it successfully captures the underlying structural similarity between the datasets. We also analyse a variety of real Saccharomyces cerevisiae datasets. In the two-dataset case, we show that MDI's performance is comparable with the present state-of-the-art. We then move beyond the capabilities of current approaches and integrate gene expression, chromatin immunoprecipitation-chip and protein-protein interaction data, to identify a set of protein complexes for which genes are co-regulated during the cell cycle. Comparisons to other unsupervised data integration techniques-as well as to non-integrative approaches-demonstrate that MDI is competitive, while also providing information that would be difficult or impossible to extract using other methods.
Use of Specific Gravity Gradient Tube for Brewery Control (1948)

(1948). Use of Specific Gravity Gradient Tube for Brewery Control. Proceedings. Annual meeting - American Society of Brewing Chemists: Vol. 6, Proceedings of the Annual Meeting 1948, pp. 36-43.
Crystal Structure of Yeast Thymidylate Kinase Complexed with the Bisubstrate Inhibitor <i>P</i><sup>1</sup>-(5‘-Adenosyl) <i>P</i><sup>5</sup>-(5‘-Thymidyl) Pentaphosphate (TP<sub>5</sub>A) at 2.0 Å Resolution:  Implications for Catalysis and AZT Activation<sup>,</sup> (1998)

The crystal structure of yeast thymidylate kinase (TmpK) complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) was determined at 2.0 A resolution. In this complex, TmpK adopts a closed conformation with a region (LID) of the protein closing upon the substrate and forming a helix. The interactions of TmpK and TP5A strongly suggest that arginine 15, which is located in the phosphate binding loop (P-loop) sequence, plays a catalytic role by interacting with an oxygen atom of the transferred phosphoryl group. Unlike other nucleoside monophosphate kinases where basic residues from the LID region participate in stabilizing the transition state, TmpK lacks such residues in the LID region. We attribute this function to Arg 15 of the P-loop. TmpK plays an important role in the phosphorylation of the AIDS prodrug AZT. The structures of TmpK with dTMP and with AZT-MP [Lavie, A., et al. (1997) Nat. Struct. Biol. 4, 601-604] implicate the movement of Arg15 in response to AZT-MP binding as an important factor in the 200-fold reduced catalytic rate with AZT-MP. TmpK from Escherichia coli lacks this arginine in its P-loop while having basic residues in the LID region. This suggested that, if such a P-loop movement were to occur in the E. coli TmpK upon AZT-MP binding, it should not have such a detrimental effect on catalysis. This hypothesis was tested, and as postulated, E. coli TmpK phosphorylates AZT-MP only 2.5 times slower than dTMP.
THE STRUCTURE AND BINDING CHARACTERISTICS OF SERUM AMYLOID PROTEIN (9.5S α1‐glycoprotein) (1982)

No difference have been observed in the properties of amyloid P-component (AP) and its serum counterpart (SAP) which might account for the deposition of the former in amyloidosis. Purified by nonselective techniques, preparations of AP and SAP were shown to have similar molecular weights and peptide composition, identical morphology in the electron microscope (EM) and to be antigenically indistinguishable. Both proteins were soluble in EDTA but readily precipitated in the presence of calcium ions, forming characteristic two-dimensional arrays in the EM. In serum however, SAP was not aggregated and sedimented at 9.5S in Ca2+ as did the purified protein in EDTA. Precipitation of purified SAP by calcium could be prevented by pretreatment with acid hydrolysates of agarose or SP Sephadex, matrices for which SAP has a calcium-dependent affinity. It is proposed that SAP circulates in combination with a low molecular weight natural ligand which prevents its aggregation. While the identity of natural ligand for SAP is as yet unknown, it is likely to resemble the glycosidic subunits in agarose.
Holographic Gratings in Azobenzene Side-Chain Polymethacrylates (1999)

Optical storage properties of thin unoriented liquid crystalline and amorphous side-chain azobenzene polymethacrylate films are examined by polarization holographic measurements. The investigated materials are free radical copolymers derived from two photochromic monomers, 6-(4-oxy-4‘-cyanoazobenzene)hex-1-yl methacrylate and 8-(4-oxy-4‘-cyanoazobenzene)oct-1-yl methacrylate, and a nonphotochromic optically active comonomer, (−)-menthyl methacrylate. The thermal behavior and phase transitions of the polymers have been investigated in detail through differential scanning calorimetry and polarizing optical microscopy. Atomic force microscopy investigations have been carried out on the polarization holographic gratings recorded in the polymethacrylate films. A surface relief grating has been found to appear in all films after irradiation. The copolymers with 50−75% dye content exhibit the largest surface relief. The stored information seems to be stable up to approximately 70 °C, except in the case of polymers with low dye content.
Review: <i>Primitive Pragmatists: The Modoc Indians of Northern California</i>, by Verne F. Ray (1965)

Book Review| March 01 1965 Review: Primitive Pragmatists: The Modoc Indians of Northern California, by Verne F. Ray Primitive Pragmatists: The Modoc Indians of Northern CaliforniaVerne F. Ray J. Cudd Brown J. Cudd Brown Search for other works by this author on: This Site PubMed Google Scholar California Historical Society Quarterly (1965) 44 (1): 57–59. https://doi.org/10.2307/25155707 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Cudd Brown; Review: Primitive Pragmatists: The Modoc Indians of Northern California, by Verne F. Ray. California Historical Society Quarterly 1 March 1965; 44 (1): 57–59. doi: https://doi.org/10.2307/25155707 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCalifornia History Search This content is only available via PDF. Copyright 1964 The California Historical Society Article PDF first page preview Close Modal You do not currently have access to this content.
Silicon-chip-based mid-infrared dual-comb spectroscopy (2018)

The development of a spectroscopy device on a chip that could realize real-time fingerprinting with label-free and high-throughput detection of trace molecules represents one of the big challenges in sensing. Dual-comb spectroscopy (DCS) in the mid-infrared is a powerful technique offering high acquisition rates and signal-to-noise ratios through use of only a single detector with no moving parts. Here, we present a nanophotonic silicon-on-insulator platform designed for mid-infrared (mid-IR) DCS. A single continuous-wave low-power pump source generates two mutually coherent mode-locked frequency combs spanning from 2.6 to 4.1 μm in two silicon microresonators. A proof-of-principle experiment of vibrational absorption DCS in the liquid phase is achieved acquiring spectra of acetone spanning from 2900 to 3100 nm at 127-GHz (4.2-cm<sup>-1</sup>) resolution. These results represent a significant step towards a broadband, mid-IR spectroscopy instrument on a chip for liquid/condensed matter phase studies.
Long-term follow-up of women with genital lichen sclerosus (2013)

Genital lichen sclerosus (LS) is usually managed with potent topical corticosteroids. There is a small (<5%) increased risk of skin cancer and long-term follow-up is recommended. We audited patients discharged to the care of their general practitioner (GP) from our regional vulval clinic. Only 29% had seen their GP in the last 12 months; 53% self-examined; 48% were unaware of the need to report abnormalities immediately; 24.4% were unaware of the recommended duration of use of their 30 g tube of steroid and only 66.7% were aware of the risk of skin cancer. Further education of both LS patients and their family practitioners is required.
GENERAL PAOLI IN ENGLAND (1949)

AbstractThe experiment in democracy which Filipp' Antonio Pasquale de' Paoli made in Corsica during his administration of the island from 1755–69, deservedly excited the admiration of the civilized world. When one considers the rough and turbulent people with whom he had to deal, his achievement was indeed remarkable. But it is not my present purpose to discuss Paoli at the height of his career, at the head of his countrymen in his own island. More than half of his long life was spent in exile: for the greater part of his boyhood and youth he remained in Naples with his father, Giacinto; and after the French conquest of Corsica in 1769, he lived (except for one brief but eventful interval) upwards of thirty years in England. This article confines itself to his relations with the British Government and his manner of living during his long sojourn in this country.
Reinforcement Learning for Call Admission Control and Routing in Integrated Service Networks (1997)

In integrated service communication networks, an important problem is to exercise call admission control and routing so as to optimally use the network resources. This problem is naturally formulated as a dynamic programming problem, which, however, is too complex to be solved exactly. We use methods of reinforcement learning (RL), together with a decomposition approach, to find call admission control and routing policies. The performance of our policy for a network with approximately 10 45 different feature configurations is compared with a commonly used heuristic policy. 1 Introduction The call admission control and routing problem arises in the context where a telecommunication provider wants to sell its network resources to customers in order to maximize long term revenue. Customers are divided into different classes, called service types. Each Author to whom correspondence should be addressed. service type is characterized by its bandwidth demand, its average call holding...