gebhart/patrepeval huggingface dataset:
Heparin and protamine stimulate the production of nitric oxide. (1996)

Heparin has been shown to decrease total vascular resistance while protamine stimulates endothelium-dependent vasodilation. This study was undertaken to determine whether heparin and/or protamine could enhance endothelium-derived relaxing factor (EDRF), as determined by nitric oxide (NO) production. Porcine carotid artery endothelial cells (PAECs) were seeded on multiwell plates, grown to confluence, and exposed to heparin (1-20 U/ml) or protamine (50-200 microg/ml) for 24 hours. With the addition of the NO synthase inhibitor, N(G)-monomethyl-L-arginine (NMMA), to heparin and/or protamine, the medium samples were collected in one hour. In a parallel clinical study, plasma samples were collected from patients undergoing cardiopulmonary bypass (CPB). The NO production was measured as reflected by the formation of nitrite (NO2-) and nitrate (NO3-), the stable end-metabolites of NO. NO production by PAECs was significantly increased by heparin > or = 5 U/ml or protamine > or = 50 microg/ml in a concentration-dependent manner. The increase of NO production was prevented by the addition of NMMA. In CPB patients, plasma NO2-/NO3- concentration was significantly increased after heparin administration compared to the preoperative value, at which time the mean plasma heparin level was 4.9+/-0.5 U/ml. Following slow protamine infusion, there was no significant difference in plasma NO2-/NO3- concentration compared to preoperative value. In conclusion NO production increases following exposure of PAECs to heparin and/or protamine. In patients, NO concentration significantly increased after heparin administration by IV bolus, but not with a slow infusion of protamine after CPB.
Effect of Sho-saiko-to Extract on Hepatic Inflammation and Fibrosis in Dimethylnitrosamine Induced Liver Injury Rats. (2002)

Sho-saiko-to extract, a Chinese herbal medicine, is widely used for treatment of chronic hepatitis in Japan. However, it is not clear what conditions Sho-saiko-to extract improves hepatic inflammation and fibrosis. We therefore induced various stages of liver injury in model rats and administered Sho-saiko-to extract. We then evaluated the liver inflammation and liver fibrosis-improving effects of Sho-saiko-to extract. The liver injury model rats were produced by administration of various doses of dimethylnitrosamine (DMN) and Sho-saiko-to extract was administered to these rats. Then the liver inflammation and fibrosis-improving effects of Sho-saiko-to extract were evaluated according to L-asparate aminotransferase (AST), L-alanine aminotransferase (ALT), liver retinoid levels, levels of hydroxyproline, Transforming Growth Factor-beta (TGF-beta), and the liver fibrosis area. These indicators depended on the total doses of DMN. The ability of Sho-saiko-to extract to improve liver inflammation and fibrosis was limited to the following levels of the respective parameters: AST levels (234-264 U/l), ALT levels (208-232 U/l), TGF-beta levels (1102-1265 pg/g liver tissue), hydroxyproline levels (633-719 nmol/g liver tissue), and liver fibrosis area (9.7-10.6 times for normal rat). These findings suggested that Sho-saiko-to extract is effective in the treatment of liver inflammation and fibrosis up to a certain degree of severity, but it produces no improvement in more severe cases.
Shear Repair for Reinforced Concrete by Fiberglass Plate Bonding (1994)

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Aspects of combined coding and linear modulation and its application to future personal communication systems (1991)

The possibility of applying MECLCs (M-ary error correcting line codes) in conjunction with SSB transmission and linear modulation schemes is examined. Such schemes are considered to be potentially of interest for future personal communication systems. A new class of error correcting codes with defined spectra was introduced; such codes provide error control as well as a null at DC and suppressed low frequency spectrum. Comparisons with traditional systems that employ line coding and error control coding in cascade reveal that the new schemes not only have better spectral characteristics but also significantly improved error performance without incurring any penalty in increased complexity. Indeed they are generally less complex since the error control power required is significantly reduced. MECLCs therefore offer high efficiency and improved error performance.
Blivande sjuksköterskors syn på sin utbildning och kommande yrkesroll (1999)

The nursing students' knowledge comes from both theoretical and practical education. They have different kinds of support in these knowledge domains. This study's aim was to describe the nursing students'opinions concerning their education which consists of psychological, social, and cultural elements, also their attitudes toward different knowledge domains and prospective professional roles. Seventy-seven students participated in the study, a short time before their graduation in Sweden. They answered a questionnaire based on close-ended and open-ended questions. The study reveals that there is still a gap between the theoretical and practical education. The supervisor in health care seems to be most important for the students learning in the practical education while the teacher's role is not so clear. The usefulness of the literature was greater in the theoretical education than in the practical. The students'opinions of the literature were similar to their opinions about the knowledge domains. Subjects from the medical and natural sciences as well as nursing, ethics and psychology were most important. Subjects such as research methods, pedagogy, sociology, and management were of less importance. The preparation given education for the professional roles in the nursing was better suited for those in nursing than were the other special roles, such as health-information, counselling, and work management. These findings indicate that the students did not acquire a holistic view of their learning for nursing. The results further also show that most of the students planned to work in hospital and especially in medical care. Few planned to work with the elderly or in outpatient care. The study particularly demonstrates the need for both the teachers and the supervisors to be more conscious about the organisation and content of the nursing education with due consideration given to the ongoing changes in the society.
Follow-Up Study on Amyotrophic Lateral Sclerosis in Rochester, Minn., 1925 through 1984 (1986)

The incidence, secular trend and survivorship of amyotrophic lateral sclerosis in the Rochester, Minn., population has been investigated over a 60-year period, 1925 through 1984. The crude average annual incidence rate was 2.0 per 100,000 population. The rate, age- and sex-adjusted to the US 1970 white population, was 2.4 per 100,000 population (3.0 for men and 2.0 for women), with a male to female ratio of 1.5:1. Incidence rates after 1955 showed a small but nonsignificant increase compared to those of the former 30-year period. Median age at onset was 67.5 years; the incidence rates increased significantly with advancing age, but without a peak. Median survivorship was 23.8 months, and younger patients had a better prognosis than patients with an advanced age at onset. No change in duration of survivorship was observed over the period studied. Two of the 44 patients (4.5%) had a family history of amyotrophic lateral sclerosis.
An Automatic Knowledge Graph Creation Framework from Natural Language Text (2017)

Knowledge graphs (KG) play a crucial role in many modern applications. However, constructing a KG from natural language text is challenging due to the complex structure of the text. Recently, many approaches have been proposed to transform natural language text to triples to obtain KGs. Such approaches have not yet provided efficient results for mapping extracted elements of triples, especially the predicate, to their equivalent elements in a KG. Predicate mapping is essential because it can reduce the heterogeneity of the data and increase the searchability over a KG. In this article, we propose T2KG, an automatic KG creation framework for natural language text, to more effectively map natural language text to predicates. In our framework, a hybrid combination of a rule-based approach and a similarity-based approach is presented for mapping a predicate to its corresponding predicate in a KG. Based on experimental results, the hybrid approach can identify more similar predicate pairs than a baseline method in the predicate mapping task. An experiment on KG creation is also conducted to investigate the performance of the T2KG. The experimental results show that the T2KG also outperforms the baseline in KG creation. Although KG creation is conducted in open domains, in which prior knowledge is not provided, the T2KG still achieves an F1 score of approximately 50% when generating triples in the KG creation task. In addition, an empirical study on knowledge population using various text sources is conducted, and the results indicate the T2KG could be used to obtain knowledge that is not currently available from DBpedia.
Copper-Catalyzed Oxidation of Amines with Molecular Oxygen (2003)

Abstract An improved system for selective aerobic oxidation of amines to imines or nitriles is presented. It involves commercially available and inexpensive copper(I) or (II) chloride as catalyst, toluene as solvent, and MS3A as dehydrating agent under an atmospheric pressure of oxygen. A variety of amines can be used as substrates for this oxidation system to give the corresponding nitriles from primary amines (up to 97% yield; TON, up to 60) and the imines from secondary amines (up to 90% yield; TON, up to 45).
Cross-Reactivity of Anti-Digoxin Antibodies with Digitoxin Depends on Tracer Structure (1992)

The most common methods for measuring digoxin concentrations in serum are immunoassays. The prerequisite for exact determination of the digoxin value is an antibody that specifically binds digoxin. Because digitoxin differs from digoxin only in the C-12 hydroxy group, it is difficult to obtain anti-digoxin antibodies that do not cross-react with this compound. During the development of a fluorescence polarization immunoassay (FPIA) for digoxin, we investigated digoxin tracers with different structures. We found that in FPIA the digitoxin cross-reactivity of an antibody could be reduced by varying the structure of the tracer molecule.
Simplified plaque reduction neutralization assay for dengue viruses by semimicro methods in BHK-21 cells: comparison of the BHK suspension test with standard plaque reduction neutralization (1985)

A newly modified semimicro plaque reduction neutralization test (PRNT) in BHK cells was compared with a standard PRNT in bottles with LLC-MK2 monolayers and with an LLC-MK2 PRNT adapted to semimicro methods. The BHK semimicro PRNT compared favorably in terms of sensitivity in detecting dengue antibody (96%), specificity at a screening dilution (95%), and ability to detect seroconversion to dengue viruses of three serotypes (93%). Disagreements between the BHK test and the LLC-MK2 tests were attributed to greater sensitivity of the BHK test in detecting dengue type 2 (DEN-2) antibody in acute-phase sera and to apparent low-level DEN-1/DEN-3 cross-reactions in some sera in all three tests. The BHK PRNT was easier, faster, and more economical than either of the LLC-MK2 tests. Many of the benefits of the BHK PRNT derive from the fact that cells are infected while still in suspension, at the time of cell splitting, hence the term "BHK suspension test."
RETOS A LA PSICOLOGÍA EN EL TRATAMIENTO DE LA CATEGORÍA DE ESTILO DE VIDA EN EL PROCESO SALUD- ENFERMEDAD (2001)

The paper analyses the life style category and Its contribution to the understanding of the health-illness process. It proposes a definition of life style. This category is seen as the conceptual tool that enhances the study of the daily involvement of the persons in their micro and macro social environment, and lets verify hypothesis about psychological regulation of the behavior.
Sub‐10 nm High‐Aspect‐Ratio Patterning of ZnO Using an Electron Beam (2005)

An electron-beam-sensitive zinc naphthenate resist is used to pattern ZnO. Features as small as 7 nm and with an aspect ratio of ∼ 9 can be patterned. Size reduction to ∼ 5 nm is observed when these patterns are heat treated to give crystalline ZnO (see Figure). The functionality of ZnO is confirmed via photoluminescence studies.
Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response (2020)

NETs trigger tumorous inflammatory response and fuel HCC metastasis. Targeting NETs rather than neutrophils themselves can be a practice strategy against HCC metastasis.
On the Security of Multimedia Encryption Schemes Based on Multiple Huffman Table (MHT) (2006)

This paper addresses the security issues of the multimedia encryption schemes based on multiple Huffman table (MHT). A detailed analysis of known-plaintext attack is presented to show that the Huffman tables used for encryption should be carefully selected to avoid the weak keys problem. Further, we propose an efficient chosen-plaintext attack on the basic MHT method as well as the enhanced scheme inserting random bits. We also show that random rotation in partitioned bit stream cannot essentially improve the security.
Linearization of voltage-controlled oscillators using switched capacitor feedback (1987)

The voltage-frequency characteristics of any voltage-controlled oscillator can be linearized using a simple circuit containing a switched capacitor. The oscillation frequency becomes insensitive to power supply or temperature variations, and is determined only by the values of a capacitor, resistor, and the control voltage with respect to a reference voltage.
Linear Systems Approach To Fiber Characterization Using Beam Profile Measurements (1984)

The index profile and core diameter of an optical fiber are often obtained by measuring the irradiance distribution at the output of the fiber. In general, a photodiode with a pinhole aperture is used to scan across the irradiance distribution and thus measure the beam profile. Using linear systems theory, we characterize this measurement process as a convolution operation and present the mathematical formalism used to estimate the achievable measurement accuracy. Experimental data are presented which confirm the theoretical results. As an outgrowth of the linear systems analysis, we suggest the use of a scanning slit rather than a pinhole to measure irradiance distributions. We show that the scanning slit is not only easier to implement than the scanning pinhole since it allows more light to be collected, but it also provides accurate beam profile data. Data collected using both techniques (pinhole and slit scanning) are presented and compared for representative beams.
A Novel Membrane-associated Glycovariant of BEHAB/Brevican Is Up-regulated during Rat Brain Development and in a Rat Model of Invasive Glioma (2003)

BEHAB (brain-enriched hyaluronan-binding protein)/brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult rat brain. BEHAB/brevican expression is up-regulated coincident with glial cell proliferation and/or motility, including during early central nervous system development and in invasive glioma. An understanding of the molecular interactions that mediate BEHAB/brevican function is still in its infancy because of the existence of several BEHAB/brevican isoforms, each of which may mediate different functions. Here, we describe a novel BEHAB/brevican isoform, B/b130, and demonstrate that it is neither the glycosylphosphatidylinositol-linked splice variant of BEHAB/brevican nor a cleavage product of the full-length protein (B/b150). B/b130 is an underglycosylated isoform of BEHAB/brevican, lacking glycosaminoglycan chains as well as most of the sugars that invest B/b150. B/b130 localizes exclusively to the particulate fraction of rat brain and associates with the cell membrane by a previously undescribed calcium-independent mechanism. In addition, B/b130 is the major isoform of BEHAB/brevican that is up-regulated in a rat model of invasive glioma and may therefore contribute to the invasive ability of glioma cells. Further understanding of BEHAB/brevican isoforms will advance our knowledge of the function of this ECM component and may help identify new potential therapeutic targets for primary brain tumors.
Development of a sustained fluoride delivery system (2010)

Abstract Objective: To develop a novel delivery system by which fluoride incorporated into elastomeric rings, such as those used to ligate orthodontic wires, will be released in a controlled and constant manner. Materials and Methods: Polyethylene co-vinyl acetate (PEVA) was used as the model elastomer. Samples (N = 3) were prepared by incorporating 0.02 to 0.4 g of sodium fluoride (NaF) into previously prepared PEVA solution. Another group of samples prepared in the same manner were additionally dip-coated in PEVA to create an overcoat. Fluoride release studies were conducted in vitro using an ion selective electrode over a period of 45 days. The amount of fluoride released was compared to the optimal therapeutic dose of 0.7 µg F − /ring/d. Results: Only coated samples with the highest fluoride content (group D, 0.4 g of NaF) were able to release fluoride at therapeutic levels. When fluoride release from coated and uncoated samples with the same amount of NaF were compared, it was shown that the dip-coating technique resulted in a fluoride release in a controlled manner while eliminating the initial burst effect. Conclusions: This novel fluoride delivery matrix provided fluoride release at a therapeutically effective rate and profile.
Consolidated learning can be susceptible to gradually-developing interference in prolonged motor learning (2013)

When multiple items are learned in sequential order, learning for one item tends to be disrupted by subsequently learned items. Such retrograde interference has been studied with paradigms conducted over a relatively short term. Resistance to interference is generally believed to be a measure of learning or consolidation. Here, we used a finger-tapping motor sequence paradigm to examine interference in prolonged motor learning. Three groups of nine subjects participated in training sessions for 16 days, and practiced three different sequences in different orders and combinations. We found that a well-trained motor sequence was subject to a gradual interference when the subsequent learning was paired in a particular order. The results suggest that a well-learned motor memory is still susceptible to interference, and that resistance to interference in one condition does not necessarily imply full, permanent consolidation.
Antibacterial activity of substances related to <i>p</i>-aminobenzoic acid (1945)

Research Article| January 01 1945 Antibacterial activity of substances related to p-aminobenzoic acid A. R. Martin; A. R. Martin 1Research Department, Imperial Chemical Industries Limited, Blackley, Manchester, 9 Search for other works by this author on: This Site PubMed Google Scholar F. L. Rose F. L. Rose 1Research Department, Imperial Chemical Industries Limited, Blackley, Manchester, 9 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1945) 39 (1): 91–95. https://doi.org/10.1042/bj0390091 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A. R. Martin, F. L. Rose; Antibacterial activity of substances related to p-aminobenzoic acid. Biochem J 1 January 1945; 39 (1): 91–95. doi: https://doi.org/10.1042/bj0390091 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1945 CAMBRIDGE UNIVERSITY PRESS, ENGLAND1945 Article PDF first page preview Close Modal You do not currently have access to this content.
Na+/H+ exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis? (2015)

Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related signalling networks. In this manuscript, we discuss Na(+)/H(+)flux, as mediated by the sodium-hydrogen exchanger isoform 1 (NHE1), a major ion transporter involved in tumourigenesis. Allosteric activation of NHE1 by external stimuli is controlled by phosphorylation of key amino acids on its cytosolic C-terminal tail, which also acts as a signal scaffold for its regulation by intracellular protein and lipid binding partners. In breast cancer cells, pH homeostasis and proton dynamics are disrupted early in transformation. This constitutively activates NHE1, causing a reversal of the plasma membrane pH gradient, resulting in a more alkaline intracellular pH and a more acidic extracellular pH. NHE1-mediated cellular alkalinization potentiates cytoskeletal remodelling, mobilizing cells for directed migration. Concomitant redistribution of NHE1 to invadopodia, where increased proton extrusion promotes proteolytic digestion of the extracellular matrix, primes cells for invasion into the bloodstream. NHE1 hyperactivity therefore heralds an important stage in cancer cell development, critically facilitating the acquisition of the invasive phenotype necessary for metastasis to occur. The potential for targeting NHE1 in the development of novel chemotherapeutic applications is explored.
[IL-15 and autoimmune disease]. (2003)

This review attempts to define the relationship between IL-15 and autoimmune disease (AID) from IL-15's tissue distribution, expression regulation and biologic function. Meanwhile, five IL-15 dysregulation-related AIDs and four IL-15/IL-15R-targeted AID therapies are described.
Diamond Detectors for UV and X-Ray Source Imaging (2011)

This work reports on the realization and test of a compact beam-profiling system for UV and X-ray sources, based on polycrystalline CVD diamond detectors. Multistrip and pixel structures have been used for 1-D and 2-D photodetectors, respectively. A dedicated read-out electronic circuitry has been designed and used to independently sample the signal produced by each strip (or pixel), enabling a real-time beam profile reconstruction.