gebhart/patrepeval huggingface dataset:
Phase-guided thread-to-core assignment for improved utilization of performance-asymmetric multi-core processors (2009)

CPU vendors are starting to explore trade offs between die size, number of cores on a die, and power consumption leading to performance asymmetry among cores on a single chip. For efficient utilization of these performance-asymmetric multi-core processors, application threads must be assigned to cores such that the resource needs of a thread closely matches resource availability at the assigned core. This significantly complicates the task of an average programmer. The contribution of this work is a technique for automatically determining the mapping between threads and performance-asymmetric cores of a processor. Our approach, which we call phase-guided thread-to-core assignment, builds on a well-known insight that programs exhibit phase behavior. We first take code sections and group them into clusters such that each section in a cluster is likely to exhibit similar runtime characteristics. The key idea is that with this clustering, characteristics of a small number of representative sections in a cluster give insight into the behavior of the entire cluster. Thus the exhibited characteristics of the representative sections on different types of cores can be used for automating thread-to-core assignment at a lower runtime cost. Variations of our technique show up to an average 150% improvement in throughput over the stock Linux scheduler for systems with a constant feed of jobs, while maintaining comparable fairness and efficiency.
Wrist driven flexor hinge orthosis: linkage design improvements. (1983)

Wrist driven flexor hinge orthosis (WDFHO) linkage movements were analyzed graphically for existing kit form orthoses and modified orthoses. The graphical analysis indicated improved function by increased torque and resultant pinch force in modified orthoses. A geometric solution to pivot point location which will allow clinicians and orthotists to properly locate the linkage pivot points for WDFHOs was developed. Improved function was documented in 5 orthoses converted from kit form linkages to modified linkages.
Optical Beam Control Testbeds (2008)

The article of record as published may be found at http://dx.doi.org/10.2514/6.2008-6639
Shakespeare in His Time. (1961)

Journal Article Ivor Brown: Shakespeare in His Time Get access Shakespeare in His Time. By Ivor Brown. Edinburgh: Thomas Nelson and Sons, 1960. Pp. viii + 238, 52 illustrations. $4.50. A. H. R. Fairchild A. H. R. Fairchild La Jolla, California Search for other works by this author on: Oxford Academic Google Scholar Shakespeare Quarterly, Volume 12, Issue 3, Summer 1961, Pages 329–332, https://doi.org/10.2307/2867072 Published: 01 July 1961
Distributed Representations in Memory: Insights from Functional Brain Imaging (2011)

Forging new memories for facts and events, holding critical details in mind on a moment-to-moment basis, and retrieving knowledge in the service of current goals all depend on a complex interplay between neural ensembles throughout the brain. Over the past decade, researchers have increasingly utilized powerful analytical tools (e.g., multivoxel pattern analysis) to decode the information represented within distributed functional magnetic resonance imaging activity patterns. In this review, we discuss how these methods can sensitively index neural representations of perceptual and semantic content and how leverage on the engagement of distributed representations provides unique insights into distinct aspects of memory-guided behavior. We emphasize that, in addition to characterizing the contents of memories, analyses of distributed patterns shed light on the processes that influence how information is encoded, maintained, or retrieved, and thus inform memory theory. We conclude by highlighting open questions about memory that can be addressed through distributed pattern analyses.
<i>B<sub>1</sub></i> estimation using adiabatic refocusing: BEAR (2013)

This method's high dynamic range, ability to make fast projection measurements, and linear quantitative relationship between phase and B1 make it an ideal candidate for use in robust transmitter gain calibration.
Biostimulation of PCB-degrading bacteria by compounds released from plant roots (1995)

Flavonoid and coumarin compounds produced by plants supported the growth of polychlorinated biphenyl (PCB)-degrading bacteria, and the bacteria retained their PCB-degrading properties. Root leachates and washings from mulberry trees also supported the growth of a PCB-degrading bacterium. These results indicate that chemicals released by some plant roots may serve as cometabolites for PCB-degrading bacteria. Identification of the right plant species and development of appropriate cultivation practices promises to lead to an ecologically sound means to achieve sustained in situ degradation of PCBs at contaminated terrestrial sites.
Renal reduced nicotinamide adenine dinucleotide phosphate:cytochrome c reductase-mediated metabolism of the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide. (1985)

N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) metabolism was examined in vitro using microsomes prepared from rat liver and renal cortex and from rabbit liver and renal cortex and outer and inner medulla. NFTA nitroreduction was observed with each tissue. Three mol of NADPH were used per mol of NFTA reduced. Substrate and inhibitor specificity suggested that the microsomal nitroreduction was due to NADPH:cytochrome c reductase. Metabolite(s) formed bound to protein, RNA, DNA, and synthetic polyribonucleotides. Maximum covalent binding was seen with polyguanylic acid. A guanosine-NFTA adduct was isolated. Binding was inhibited by sulfhydryl compounds and vitamin E. The [14C]NFTA:glutathione or [3H]glutathione:NFTA conjugates obtained from microsomal incubations showed identical chromatographic properties as the product obtained by the reaction of synthetic N-hydroxy-NFTA with [3H]glutathione. Structures of synthetic N-hydroxy-NFTA and the microsomal reduction product 1-[4-(2-acetylaminothiazolyl)]-3-cyano-1-propanone were established by mass spectrometry. The latter reduction product did not bind macromolecules. These results suggest that renal NADPH:cytochrome c reductase reduces NFTA to an N-hydroxy-NFTA intermediate that binds nucleophilic sites on macromolecules.
Business process reengineering: critical success factors in higher education (2007)

Purpose The purpose of this paper is to examine the critical success factors of business process reengineering (BPR) in higher education (HE). Design/methodology/approach Empirical case studies collected from three private higher education institutions in Malaysia, which have embarked on BPR successfully. Findings Seven factors were found to be critical to BPR implementation success. The factors are teamwork and quality culture, quality management system and satisfactory rewards, effective change management, less bureaucratic and participative, information technology/information system, effective project management and adequate financial resources. Research limitations/implications The paper provides a framework for future research to explore organisational development in making BPR happen successfully. Originality/value This research contributes to studies of BPR in HE context, by considering the soft issues in its implementation.
Systemic Lupus Erythematosus: Evolving Concepts (1979)

Systemic lupus erythematosus, a disease of unknown cause and protean manifestations, continues to excite substantial investigational interest. These papers bring together recent advances in concepts of its immunopathogenesis, evidence for a major genetic role in the causation of the process, developing systems for the morphologic assessment of its often fatal nephritis, and data from ongoing trials of cytotoxic drugs in its management.
A Non-Coherent 802.15.4a UWB Impulse Radio (2007)

The new IEEE 802.15.4a standard for Wireless Personal Area Networks (WPAN) extends the capabilities of its popular predecessor IEEE 802.15.4, and enables accurate range/distance estimation between communicating devices. In addition to its ranging capabilities, the new standard also defines several new data rates ranging from 100 kb/s to 27 Mb/s and a variety of options that give IEEE 802.15.4a compliant devices a high degree of flexibility and scalability. In this article we describe our implementation of an UWB impulse radio device, which is compliant with the 802.15.4a standard. Our implementation uses non-coherent energy-detection based receivers both to demodulate data and to detect ranges. We will present our prototype system and discuss some implementation details (energy detection, sampling rates, acquisition/synchronization) specific to non-coherent receivers. The performance of our prototype system is discussed as well. The reported range estimation error is less than 30cm, which agrees well with theoretical predictions.
High infiltration of tumor‐associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer (2015)

Infiltration of TAMs, especially M2 macrophages, is associated with a poor response to chemotherapy and poor prognosis of patients with esophageal cancer.
Neonatal granulocytosis is a postpartum event which is seen in the liver as well as in the blood (1997)

In a recent series of studies, we demonstrated that stress in humans and animals, with resultant sympathetic nerve strain, induces severe granulocytosis, because granulocytes carry adrenergic receptors on the surface. Because activated granulocytes produce free radicals and superoxides, they sometimes induce tissue damage if the stress is too strong or continuous. Human neonates are also known to show high levels of granulocytes in the peripheral blood. In this study, we investigated whether such neonatal granulocytosis are a stress-associated response at birth. Both human and mouse materials, before and after birth, were used. The number of leukocytes in the blood, as well as some other factors in the serum, were measured. Although levels of granulocytes were found to be low in fetal humans and mice, they increased sharply after birth. In parallel with this postpartal granulocytosis, transaminases in sera increased transiently. In reference to results of a transient elevation in the levels of catecholamines at birth in mice, all these phenomena resemble stress-associated responses. Indeed, fatty liver and hematopoietic destruction in the liver were also observed in mice and humans. At this time, the production of inducible nitric oxide synthase (iNOS) by granulocytes in the liver was evident. These results suggest that neonatal granulocytosis is a postpartum event which results from various stresses (e.g., oxygen stress) at birth. This event may be responsible for such well-known neonatal phenomena as the termination of fetal hematopoiesis in the liver and as neonatal jaundice.
Fabrication of Transparent and Flexible Organic Field-Effect Transistors with Solution-Processed Graphene Source–Drain and Gate Electrodes (2011)

Transparent organic field-effect transistors with solution-processed graphene source–drain and gate electrodes were fabricated on flexible substrates. Graphene electrodes were formulated by chemical and thermal reduction of solution-processed graphene oxide films. A graphene gate electrode, a gate dielectric layer, and an organic active layer were coated on a transparent flexible polyimide film. Next, graphene source–drain electrodes, which had been formed on another glass substrate, were peeled off and transferred onto the active layer using a thermal release tape. The transparent and flexible poly(3-hexylthiophene) transistor with graphene electrodes showed p-type characteristics with hole mobility of 2.3×10-2 cm2·V-1·s-1.
Spatially Controlled Cell Adhesion via Micropatterned Surface Modification of Poly(dimethylsiloxane) (2006)

Spatial control of cell growth on surfaces can be achieved by the selective deposition of molecules that influence cell adhesion. The fabrication of such substrates often relies upon photolithography and requires complex surface chemistry to anchor adhesive and inhibitory molecules. The production of simple, cost-effective substrates for cell patterning would benefit numerous areas of bioanalytical research including tissue engineering and biosensor development. Poly(dimethylsiloxane) (PDMS) is routinely used as a biomedical implant material and as a substrate for microfluidic device fabrication; however, the low surface energy and hydrophobic nature of PDMS inhibits its bioactivity. We present a method for the surface modification of PDMS to promote localized cell adhesion and proliferation. Thin metal films are deposited onto PDMS through a physical mask in the presence of a gaseous plasma. This treatment generates topographical and chemical modifications of the polymer surface. Removal of the deposited metal exposes roughened PDMS regions enriched with hydrophilic oxygen-containing species. The morphology and chemical composition of the patterned substrates were assessed by optical and atomic force microscopies as well as X-ray photoelectron spectroscopy. We observed a direct correlation between the surface modification of PDMS and the micropatterned adhesion of fibroblast cells. This simple protocol generates inexpensive, single-component substrates capable of directing cell attachment and growth.
USEFULNESS OF THE HEMAGGLUTINATION TEST USING TREPONEMA PALLIDUM ANTIGEN (TPHA) FOR THE SERODIAGNOSIS OF SYPHILIS (1969)

The passive hemagglutination test for serodiagnosis of syphilis with an antigen derived from pathogenic Treponema pallidum was investigated. The use of an improved reaction medium and the pretreatment of test serum with an antigen derived from a strain of non-pathogenic treponemes eliminated most of non-specific reactions. The method is highly specific and sensitive and is very simple to perform. The lyophilized antigen can be stored for a year without any appreciable change in the antigenicity. Thus, the method will be very useful for routine serodiagnosis of syphilis.
Aroma Evolution during Flower Opening in Rosa damascena Mill (1999)

Abstract The changes of aroma ingredients during the process of flower opening from Bulgarian rose were monitored by head space method and solvent extraction.W e also analyzed contents of glycosidic alcoholic aroma together with activities of the hydrolytic enzymes throughout the flower development and the opening. At flower petal opening time, the total amount of aromas in the head space gas reached the highest level. The concentration of citronellol was abundant in the head space gas at this stage, whereas the concentration o f 2-phenylethanol became higher than that of citronellol 4 hr after the opening stage. In the volatile extracts, higher accumulation was observed in 2-phenylethanol than those of monoterpenoids at this stage, and the content of the former still increased after flower opening. Glycosidic citronellol, geraniol, and other m onoterpenes started their accumulation ju st before flower opening stage and then reached the maximum level. The amount of these glycosidic compounds were less than those in the volatile extracts. In contrast to the monoterpenes, 2-phenylethyl glycosides accumulated in a higher level than in the volatile extracts starting at least 12 hr before the opening stage. The amount of the glycosidic precursors of 2-phenylethanol detected in the rose petals before flower opening always was higher than the amount of 2-phenylethanol which was released later. The decline of glycosidic 2-phenylethanol at flower opening stage may be due to partial enzymatic hydrol­ysis. Thereafter a drastic decline was observed, indicating that rapid enzymatic hydrolysis occurred during these stages.
Purine and pyrimidine metabolism (1982)

The pathways of purine biosynthesis and degradation have been elucidated during the last 30 years; the regulation of the mechanisms involved is not yet fully understood, particularly with respect to quantitative aspects. Research into inborn errors of purine metabolism has provided valuable insights into purine synthesis and salvage pathways. Nutrition experiments using purine-free formula diets and supplements with defined purine sources permit precise descriptions of the influence of various dietary purines on uric acid formation. Supplements of dietary purines produce dose-proportional increases in plasma uric acid concentrations, uric acid pool size and renal uric acid excretion. The magnitude of these increases depends on the type of purine compound administered, which may limit the value of food tables for human dietetics. Purine content of food must be related not only to weight but also to energy and to protein, particularly if new foodstuffs or a vegetarian diet are ingested. Dietary purines appear to influence the biosynthesis of pyrimidines. In contrast to dietary purines, pyrimidines in the diet, if administered as nucleosides or nucleotides, are utilized in animals for the synthesis of nucleic acids. Much further work is necessary for a better understanding of the inter-relationships of purine and pyrimidine metabolism.
Permethyl analog of the pyrrolic antibiotic distamycin A (1981)

The synthesis of an analogue of distamycin A, a pyrrolic oligopeptide possessing antiviral and antibiotic activity, is described in which each of the three pyrrole rings is fully methylated. This structural modification results in pyrrole rings which are extraordinarily electron rich and required the development of a new synthetic approach to these polypyrrolic amides. The key reactions involved development of a general method for the synthesis of 3-aminopyrroles and for formation of an amide bond between a pyrrole-2-carboxylic acid and these 3-aminopyrroles. Since the acid is hindered, a poor electrophile, and acid sensitive, while the amine is unstable and a hindered, weak nucleophile, amide bond formation under the usual conditions was poor. A very efficient method, however, was developed involving the isolation of 1-hydroxybenzotriazole active ester prepared in situ from another active ester. Neither the mono-, di-, nor tripyrrolic permethyl analogues were effective antimalarials, and none showed anticancer activity.
High luminous efficiency thin-film electroluminescent devices with low resistivity insulating materials (1992)

In order to fabricate high brightness and high efficiency thin-film electroluminescent (EL) devices, the emission characteristics of devices employing low resistivity and high dielectric constant materials, such as radio-frequency-sputtered HfO2 films, have been studied. It was found that the EL device with a glass/indium tin oxide/BaTiO3/ZnS:TbF3/HfO2/Ta2O5/HfO2/Al structure exhibited higher brightness and higher efficiency than the other devices. The highest luminous efficiency (η) and brightness of 0.9 lm/W and 1000 cd/m2, respectively, were obtained at 1-kHz sinusoidal wave voltage excitation. This was mainly due to the insulating layers adjacent to the active layer, which have low resistivity and high dielectric constant. So, it has higher density of interface states and deeper interface states at HfO2–ZnS and BaTiO3–ZnS interfaces.
A new electronic controlled suspension using piezo-electric ceramics (2002)

A new electronic controlled suspension system called Piezo TEMS (Toyota electronic modulated suspension) is developed by using piezoelectric ceramics for a sensor, and an actuator. As a result, good drivability and vehicle stability can be obtained with an improved riding comfort.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Terahertz-Pulse Emission Through Laser Excitation of Surface Plasmons in a Metal Grating (2007)

The second-order processes of optical-rectification and photoconduction are well known and widely used to produce ultrafast electromagnetic pulses in the terahertz frequency domain. We present a new form of rectification that relies on the excitation of surface plasmons in metal films deposited on a shallow grating. Multiphoton ionization and ponderomotive acceleration of electrons in the enhanced evanescent field of the surface plasmons results in a femtosecond current surge and emission of terahertz electromagnetic radiation. Using gold, this rectification process is third or higher-order in the incident field.
Chemical JAK inhibitors for the treatment of rheumatoid arthritis (2016)

Considerable advances in the treatment of rheumatoid arthritis (RA) have been made following the advent of biological disease-modifying anti-rheumatic drugs (DMARDs). However, biological DMARDs require intravenous or subcutaneous injection and some patients fail to respond to these drugs or lose their primary response. Currently, Janus kinase (JAK) inhibitors have been developed as a new class of DMARD that inhibits the non-receptor tyrosine kinase family JAK involved in intracellular signaling of various cytokines and growth factors. Areas covered: Several JAK inhibitors such as tofacitinib and baricitinib are oral synthetic DMARD that inhibit JAK1, 2 and 3. Both drugs have shown feasible efficacy and tolerable safety. In this article, efficacy and adverse events from the phase III trials of JAK inhibitors are overviewed. In addition, pharmacokinetics and mechanism of action of JAK inhibitors in relevance to efficacy and adverse events are covered. Expert opinion: JAK inhibitors are novel therapies for RA that inhibit multiple cytokines and signaling pathways. Further studies are needed to determine their risk-benefit ratio and selection of the most appropriate patients for such therapy.
Effects of Carnitine on Peripheral Blood Mitochondrial DNA Copy Number and Liver Function in Non-Alcoholic Fatty Liver Disease (2010)

In NAFLD, the carnitine improved liver profile and peripheral blood mitochondrial DNA copy number. This results suggest that carnitine activate the mitochondria, thereby contributing to the improvement of NAFLD.
Identification of immunogenic antigens using a phage-displayed cDNA library from an invasive ductal breast carcinoma tumour (2001)

The identification of immunogenic antigens for serological testing and vaccine development is a major challenge facing cancer immunology research. To study the humoral immune response in patients with breast cancer, a T7 phage display cDNA library from an invasive ductal breast carcinoma was panned on patient serum IgG antibodies. By monitoring the selection with an immunoscreening technique, positive phage-displayed cDNA products reacting with breast cancer patient IgG antibodies were selected. Sequence analysis identified immunogenic antigens such as the cytochrome oxidase I, sp100 and Ran GTPase activating protein. Additionally, immunogenic uncharacterized gene products were also identified. Both the known and unknown immunoselected gene products should offer an additional source for cancer gene discovery for diagnostic testing and vaccine development.
The microbiome and childhood diseases: Focus on brain‐gut axis (2015)

Many childhood diseases such as autism spectrum disorders, allergic disease, and obesity are on the increase. Although environmental factors are thought to play a role in this increase. The mechanisms at play are unclear but increasing evidence points to an interaction with the gastrointestinal microbiota as being potentially important. Recently this community of bacteria and perturbation of its colonization in early life has been linked to a number of diseases. Many factors are capable of influencing this colonization and ultimately leading to an altered gut microbiota which is known to affect key systems within the body. The impact of the microbial composition of our gastrointestinal tract on systems outside the gut is also becoming apparent. Here we highlight the factors that are capable of impacting on microbiota colonization in early-life and the developing systems that are affected and finally how this may be involved in the manifestation of childhood diseases.