gebhart/patrepeval huggingface dataset:
Trusting Anomaly and Intrusion Claims for Cooperative Distributed Intrusion Detection Schemes of Wireless Sensor Networks (2008)

Any unidentified malicious nodes in the network could send faulty anomaly and intrusion claims about the legitimate nodes to the other nodes. Verifying the validity of such claims is a critical and challenging issue that is not considered in existing cooperative-based distributed anomaly and intrusion detection schemes of wireless sensor networks. In this paper, we propose a validation algorithm that addresses this problem. This algorithm utilizes the concept of intrusion-aware reliability that helps to provide adequate reliability at the modest communication cost.
Broadband 300 MHz IF Amplifier Design (1969)

Short hop radio systems of the type described in this issue require broadband intermediate frequency amplifiers in the range of a few hundred MHz which have a large gain control range and stable characteristics with respect to temperature; they must also make efficient use of bias power and have well behaved noise properties. This paper describes the design of such amplifiers. We give extensive measurements for an amplifier with a 1 dB bandwidth of 120 MHz centered at 300 MHz and an automatic gain control range of 43 dB.
Comparison of gamma-ray-induced chromosome ring and inversion frequencies. (1995)

A method was used to detect chromosome inversions as apparent or false sister chromatid exchanges (SCEs) in the first mitosis after gamma irradiation of human G0 cells. Dose-response relationships for small inversions have not been measured and reported previously, but it has been assumed that these are induced with a frequency equal to that of their easily measured asymmetrical counterpart, the interstitial deletion. Our experiments confirm this expectation. The results also demonstrate, as others have suggested, that in protocols where SCEs have been reported in the first postirradiation mitosis after incorporation of BrdU in the previous cell cycle, the X- or gamma-ray treatment of G0- or G1-phase cells produces virtually no true SCEs.
A TCP-friendly rate adjustment protocol for continuous media flows over best effort networks (1999)

No abstract available.
Chemotaxis of <i>Silicibacter</i> sp. Strain TM1040 toward Dinoflagellate Products (2004)

The alpha-proteobacteria phylogenetically related to the Roseobacter clade are predominantly responsible for the degradation of organosulfur compounds, including the algal osmolyte dimethylsulfoniopropionate (DMSP). Silicibacter sp. strain TM1040, isolated from a DMSP-producing Pfiesteria piscicida dinoflagellate culture, degrades DMSP, producing 3-methylmercaptopropionate. TM1040 possesses three lophotrichous flagella and is highly motile, leading to a hypothesis that TM1040 interacts with P. piscicida through a chemotactic response to compounds produced by its dinoflagellate host. A combination of a rapid chemotaxis screening assay and a quantitative capillary assay were used to measure chemotaxis of TM1040. These bacteria are highly attracted to dinoflagellate homogenates; however, the response decreases when homogenates are preheated to 80 degrees C. To help identify the essential attractant molecules within the homogenates, a series of pure compounds were tested for their ability to serve as attractants. The results show that TM1040 is strongly attracted to amino acids and DMSP metabolites, while being only mildly responsive to sugars and the tricarboxylic acid cycle intermediates. Adding pure DMSP, methionine, or valine to the chemotaxis buffer resulted in a decreased response to the homogenates, indicating that exogenous addition of these chemicals blocks chemotaxis and suggesting that DMSP and amino acids are essential attractant molecules in the dinoflagellate homogenates. The implication of Silicibacter sp. strain TM1040 chemotaxis in establishing and maintaining its interaction with P. piscicida is discussed.
Morphological Alterations of the Fission Yeast Schizosaccharomyces pombe in the Presence of Aculeacin A: Spherical Wall Formation (1985)

The fission yeast Schizosaccharomyces pombe, grown in the presence of aculeacin A (Acu), an antifungal antibiotic, forms spherical rather than cylindrical walls. This aberrant morphogenesis was studied in the presence of Acu at 1 μg ml–1 under conditions in which over 90% of the cells continued to grow but with altered morphology. Microscopic observations and chemical analyses revealed that the spherical walls had a looser structure than the cylindrical wall and that their syntheses of alkali-insoluble glucan and mannan were reduced whereas the synthesis of alkali-soluble glucan was enhanced. Spherical walls of glutaraldehyde-fixed cells were hardly digested by Zymolyase 60000 [a (1→3)-β-glucanase] but were digested by Novozym 234 [a (1→3)-α-glucanase]. From these results the components and morphology of the spherical walls are discussed in comparison with the cylindrical walls.
Purification and characterization of 6‐pyruvoyl tetrahydropterin synthase from salmon liver (1989)

Salmon liver was chosen for the isolation of 6‐pyruvoyl tetrahydropterin synthase, one of the enzymes involved in tetrahydrobiopterin biosynthesis. A 9500‐fold purification was obtained and the purified enzyme showed two single bands of 16 and 17 kDa on SDS/PAGE. The native enzyme (68 kDa) consists of four subunits and needs free thiol groups for enzymatic activity as was shown by reacting the enzyme with the fluorescent thiol reagent N ‐(7‐dimethylamino‐4‐methylcoumarinyl)‐maleimide. The enzyme is heat‐stable up to 80°C, has an isoelectric point of 6.0–6.3, and a pH optimum at 7.5. The enzyme is Mg 2+ ‐dependent and has a Michaelis constant for its substrate dihydroneopterin triphosphate of 2.2 μ. The turnover number of the purified salmon liver enzyme is about 50 times as high as that of the enzyme purified from human liver. It does not bind to the lectin concanavalin A, indicating that it is free of mannose and glucose residues. Polyclonal antibodies raised against the purified enzyme in Balb/c mice were able to immunoprecipitate enzyme activity. The same polyclonal serum was not able to immunoprecipitate enzyme activity of human liver 6‐pyruvoyl tetrahydropterin synthase, nor was any cross‐reaction in ELISA tests seen.
Nonuniqueness in the inverse scattering problem (1978)

The inverse scattering problem consists of determining the functional form of a scattering potential given the scattering matrix A (k0s, k0s0) for all scattering directions s and one or more values of the wave vector k0s0. In this paper it is shown that within the framework of the first Born approximation the inverse scattering problem as defined above does not possess a unique solution. It is also shown that within the framework of exact (potential) scattering theory the problem does not admit a unique solution given only the scattering matrix for a single fixed value of the wave vector k0s0 as data. The final section in the paper considers scattering experiments using incident fields other than plane waves and where knowledge of the scattered field at all points exterior to the scattering volume is available as data. It is found that, within the framework of exact scattering theory, the data generated by any single such experiment is not sufficient to uniquely specify the scattering potential while, within the framework of the first Born approximation, the data generated by any finite number of such experiments is not sufficient to uniquely specify the potential.
Lignan contents in sesame seeds and products (2007)

Abstract Sesame seed ( Sesamum indicum L.) is a rich source of furofuran lignans with a wide range of potential biological activities. The major lignans in sesame seeds are the oil‐soluble sesamin and sesamolin, as well as glucosides of sesaminol and sesamolinol that reside in the defatted sesame flour. Upon refining of sesame oil, acid‐catalyzed transformation of sesamin to episesamin and of sesamolin to epimeric sesaminols takes place, making the profile of refined sesame oils different from that of virgin oils. In this study, the total lignan content of 14 sesame seeds ranged between 405 and 1178 mg/100 g and the total lignan content in 14 different products, including tahini, ranged between 11 and 763 mg/100 g. The content of sesamin and sesamolin in ten commercial virgin and roasted sesame oils was in the range of 444–1601 mg/100 g oil. In five refined sesame oils, sesamin ranged between 118 and 401 mg/100 g seed, episesamin between 12 and 206 mg/100 g seed, and the total contents of sesaminol epimers between 5 and 35 mg/100 g seed, and no sesamolin was found. Thus, there is a great variation in the types and amounts of lignans in sesame seeds, seed products and oils. This knowledge is important for nutritionists working on resolving the connection between diet and health. Since the consumption of sesame seed products is increasing steadily in Europe and USA, it is important to include sesame seed lignans in databases and studies pertinent to the nutritional significance of antioxidants and phytoestrogens. It is also important to differentiate between virgin, roasted and refined sesame oils.
Coverage comparison of short range radar networks vs. conventional weather radars: Case study in the northwestern United States (2009)

The West Coast of Washington and the NE and SW comers of Wyoming are regions of the contiguous United States where NEXRAD coverage is incomplete. One approach to addressing these gaps is to install additional NEXRAD-class radars. Another potential approach is to install small radar networks of the type being investigated in the CASA project. This paper compares these two approaches. We provide a meteorological and user-need assessment of present radar coverage in these regions (based on a recent feasibility study led by J. Brotzge) as well as an objective assessment of the radar-coverage that would be achieved using the large radar and small radar approaches. For this evaluation we consider two classes of radar: long-range radars having similar attributes to the WSR-88D (i.e., 10 cm wavelength, >250 km maximum range, 1 degree beamwidth, -500 kW peak power); and short-range radars having attributes similar to those operating in CASA's Oklahoma prototype network (i.e., 3 cm wavelength, 40 km maximum range, 2 degree beamwidth). We first establish the number of both types of radar that would be needed to provide coverage over a given rectangular ground-domain. Next, we quantify the coverage-versus-altitude for both weather-event detection and precipitation estimation over these regions, considering the blockage caused by both the curved earth and the local terrain.
The partial silicon-on-insulator technology for RF power LDMOSFET devices and on-chip microinductors (2002)

A new partial silicon-on-insulator (SOI) formation technology and the associated RF LDMOSFET device structure on a silicon bulk substrate are proposed in this paper. The same technology can also be applied to enhance the quality factor of the integrated on-chip microinductors. The proposed technology is able to reduce both drain/substrate parasitics and leakage current for devices fabricated on bulk substrates. At the same time, the approach overcomes the thermal problem encountered by devices fabricated on full-SOI substrates. To demonstrate the technology, both partial-SOI LDMOSFET and microinductor devices were fabricated on a bulk wafer with their RF performance verified by laboratory measurements.
Chemonucleolysis: advantages and disadvantages. (1990)

The authors report their experience with 60 patients treated for lumbar disc herniation by chemonucleolysis with chymopapain and followed-up 1 to 3 years after treatment. Long-term results were as follows: excellent: 50%; good: 40%; fair: 8.2%; poor: 1.8%. The high percentage of positive results is attributed to the rigid criteria for patient selection used, which resulted in treatment by chemonucleolysis in only 18.6% of the surgical cases of lumbar disc pathology observed. 27.2% of the patients treated complained of disorders which resulted in postoperative complications and/or prolonged convalescence: prolonged low back pain and vertebral stiffness in 20%, persistent contralateral sciatic pain in 5.4%; intense but transitory worsening of the sciatica in 1.8%. The most feared complication of chemonucleolysis is paraplegia occurring after the inadverted injection of the enzyme into the spinal fluid. This risk overshadows the positive attributes of the method. The most important advantage of chemonucleolysis, as compared with surgery, is that it avoids epidural scarring and permanent postoperative anatomical changes. Patients may benefit from these advantages, but they must be willing to accept the negative aspects of the method, as well.
Phenotypic modulation of human hair matrix cells (trichocytes) by environmental influence in vitro and in vivo. (1993)

Trichocytes, i.e. precursor cells of the hair cortex and medulla, isolated from plucked human scalp hair follicles (HF) were propagated on feeder layers of post-mitotic human dermal fibroblasts (HDF). Cell isolates from five HF routinely yielded about 0.5-1 x 10(5) cells within 3 weeks. When grown as 'surface epithelia' in vitro (on dermal equivalents exposed to air), trichocytes organized into stratified epithelia largely reminiscent of epidermis with regard to both tissue architecture and localization of epidermal differentiation products (keratins K1 and K10, involucrin, filaggrin). However, when HDF in the collagen matrix were replaced by dermal papilla cells (DPC) epidermoid differentiation was largely prevented while still allowing growth and stratification. Epidermal differentiation (keratinization) was virtually complete when trichocytes grown on collagen gels with HDF were transplanted onto nude mice; this was apparent by tissue organization, expression of K1 and K10 and the nearly regular epidermal localization of involucrin. In addition, the deposition of basement membrane components (laminin, type IV collagen, bullous pemphigoid antigen) at the epithelium-collagen interface further increased and was more regular in transplants than in vitro. Cells embedded in Matrigel together with HDF developed large spheroidal structures with inward-directed differentiation and all the epidermal markers found in 'surface' cultures, while only small keratinizing spheroids formed without HDF. In this system co-culture of trichocytes with DPC suppressed almost completely epidermal keratinization. Although typical hair proteins were not detectable, our data clearly demonstrate that: (1) bona fide trichocytes inherit the options for alternative directions of differentiation, and (2) external (in part mesenchymal cell-mediated) influences play a pivotal role in this determination.
Immunization with <i>Salmonella enterica</i> Serovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge with <i>Streptococcus pneumoniae</i> (2010)

Gram-negative bacteria produce outer membrane vesicles (OMVs) that serve a variety of functions related to survival and pathogenicity. Periplasmic and outer membrane proteins are naturally captured during vesicle formation. This property has been exploited as a method to derive immunogenic vesicle preparations for use as vaccines. In this work, we constructed a Salmonella enterica serovar Typhimurium strain that synthesized a derivative of the pneumococcal protein PspA engineered to be secreted into the periplasmic space. Vesicles isolated from this strain contained PspA in the lumen. Mice intranasally immunized with the vesicle preparation developed serum antibody responses against vesicle components that included PspA and Salmonella-derived lipopolysaccharide and outer membrane proteins, while no detectable responses developed in mice immunized with an equivalent dose of purified PspA. Mucosal IgA responses developed against the Salmonella components, while the response to PspA was less apparent in most mice. Mice immunized with the vesicle preparation were completely protected against a 10× 50% lethal dose (LD₅₀) challenge of Streptococcus pneumoniae and significantly protected against a 200× LD₅₀ challenge, while control mice immunized with purified PspA or empty vesicles were not protected. These results establish that vesicles can be used to mucosally deliver an antigen from a Gram-positive organism and induce a protective immune response.
Aluminium foil as a potential substrate for ATR-FTIR, transflection FTIR or Raman spectrochemical analysis of biological specimens (2015)

Aluminium foil is a potential low-cost alternative substrate for spectrochemical analyses: facilitating translation to a routine clinical or laboratory setting.
Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer (2012)

Twenty-five patients with chemotherapy refractory cancer were treated with a fully serotype 3-based oncolytic adenovirus Ad3-hTERT-E1A. In mice, Ad3 induced higher amounts of cytokines but less liver damage than Ad5 or Ad5/3. In humans, the only grade 3 adverse reactions were self-limiting cytopenias and generally the safety profile resembled Ad5-based oncolytic viruses. Patients that had been previously treated with Ad5 viruses presented longer lasting lymphocytopenia but no median increase in Ad3-specific T-cells in blood, suggesting immunological activity against antigens other than Ad3 hexon. Frequent alterations in antitumor T-cells in blood were seen regardless of previous virus exposure. Neutralizing antibodies against Ad3 increased in all patients, whereas Ad5 neutralizing antibodies remained stable. Treatment with Ad3-hTERT-E1A resulted in re-emergence of Ad5 viruses from previous treatments into blood and vice versa. Signs of possible efficacy were seen in 11/15 (73%) patients evaluable for tumor markers, four of which were treated only intravenously. Particularly promising results were seen in breast cancer patients and especially those receiving concomitant trastuzumab. Taken together, Ad3-hTERT-E1A seems safe for further clinical testing or development of armed versions. It offers an immunologically attractive alternative, with possible pharmacodynamic differences and a different receptor compared to Ad5.
Methods for Maintaining Insect Cell Cultures (2002)

Insect cell cultures are now commonly used in insect physiology, developmental biology, pathology, and molecular biology. As the field has advanced from methods development to a standard procedure, so has the diversity of scientists using the technique. This paper describes methods that are effective for maintaining various insect cell lines. The procedures are differentiated between loosely or non-attached cell strains, attached cell strains, and strongly adherent cell strains.
Energetic-multiple-charged-ion sources on short-laser-pulse irradiated foils (2000)

The emission of multi-MeV multiple-charged ions from a thin metallic target irradiated by a short pulse laser in the range of intensity 1016–20 W/cm2 is investigated via a full kinetic particle-in-cell simulations including transient plasma ionization. Ions over MeV energy are accelerated from non-low-Z matter with up to a 10% conversion from laser energy. The anisotropy of the electron velocity distribution is found to enhance the ion energy and improve the emittance.
Immersion defect reduction, part I: analysis of water leaks in an immersion scanner (2007)

This paper reports the water-leakage mechanism of the immersion hood in an immersion scanner. The proposed static analysis reveals the immersion hood design performance in defect distribution. A dynamic water-leakage model traces the leaked water and identifies its position on the wafer, during exposure. Comparing simulation to experimental results on bare-silicon and resist-coated wafers, the defect type, source of residuals, and critical settings on the immersion system were clearly identified.
Fractal network dimension and viscoelastic powerlaw behavior: I. A modeling approach based on a coarse-graining procedure combined with shear oscillatory rheometry (2012)

Recent advances in dynamic elastography and biorheology have revealed that the complex shear modulus, G*, of various biological soft tissues obeys a frequency-dependent powerlaw. This viscoelastic powerlaw behavior implies that mechanical properties are communicated in tissue across the continuum of scales from microscopic to macroscopic. For deriving constitutive constants from the dispersion of G* in a biological tissue, a hierarchical fractal model is introduced that accounts for multiscale networks. Effective-media powerlaw constants are derived by a constitutive law based on cross-linked viscoelastic clusters embedded in a rigid environment. The spatial variation of G* is considered at each level of hierarchy by an iterative coarse-graining procedure. The establishment of cross-links in this model network is associated with an increasing fractal dimension and an increasing viscoelastic powerlaw exponent. This fundamental relationship between shear modulus dynamics and fractal dimension of the mechanical network in tissue is experimentally reproduced in phantoms by applying shear oscillatory rheometry to layers of tangled paper strips embedded in agarose gel. Both model and experiments demonstrate the sensitivity of G* to the density of the mechanical network in tissue, corroborating disease-related alterations of the viscoelastic powerlaw exponent in human parenchyma demonstrated by in vivo elastography.
Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management (2010)

There is wide individual variability in the pharmacokinetics, pharmacodynamics, and tolerance to anticancer drugs within the same ethnic group and even greater variability among different ethnicities. Pharmacogenomics (PG) has the potential to provide personalized therapy based on individual genetic variability in an effort to maximize efficacy and reduce adverse effects. The benefits of PG include improved therapeutic index, improved dose regimen, and selection of optimal types of drug for an individual or set of individuals. Advanced or metastatic breast cancer is typically treated with single or multiple combinations of chemotherapy regimens including anthracyclines, taxanes, antimetabolites, alkylating agents, platinum drugs, vinca alkaloids, and others. In this review, the PG of breast cancer therapeutics, including tamoxifen, which is the most widely used therapeutic for the treatment of hormone-dependent breast cancer, is reviewed. The pharmacological activity of tamoxifen depends on its conversion by cytochrome P450 2D6 (CYP2D6) to its abundant active metabolite, endoxifen. Patients with reduced CYP2D6 activity, as a result of either their genotype or induction by the coadministration of other drugs that inhibit CYP2D6 function, produce little endoxifen and hence derive limited therapeutic benefit from tamoxifen; the same can be said about the different classes of therapeutics in breast cancer. PG studies of breast cancer therapeutics should provide patients with breast cancer with optimal and personalized therapy.
The Research and Implementation of the Mid-Frequency Power (2014)

This paper discusses the research and implementation of the mid-frequency power (MFP). The paper analyzes the present research situation and the existence question of 400Hz mid-frequency power supply. Then the research of full digital control realization process of mid-frequency power supply with high power factor and multiple closed-loop feedback (MCLF) is given. The principle and characteristic of the closed-loop control system are provided. Finally the experimental prototype taking DSP of TMS320F2812 type as control device is developed. The experimental results verify the rationality .