gebhart/patrepeval huggingface dataset:
Capstone HRM: dynamics and ambiguity in the workplace (2015)

Capstone HRM: Dynamics in the Workplace provides students, academics and practitioners with an alternative view of activities associated with managing people at work. Assuming readers have a sound understanding of 'best practice' human resource management (HRM) techniques; it seeks to speak to people fascinated by the puzzle posed by the real world of human resource management (HRM). HRM broadly refers to the activities associated with the management of the people who do the work of organizations, while strategic HRM assumes that HRM activities are integrated with strategic objectives, and improve organizational performance. Unfortunately, often HRM policies represent an intent rather than the actual practice of managing people. Capstone HRM: Dynamics in the Workplace grapples with these complexities, adopting a framework which captures the inter-relationships between national and international (macro) factors, organizational (meso) factors, and individual and group dynamics (micro) operating in the workplace.This framework highlights a number of themes common to the modern, dynamic workplace, including: International and national factors Globalization The contradictions and ambiguities of HRM policies and practices The desire to measure outcomes The embedded nature of ethics in HRM and SHRM, and its relationship to CSR The valuing of human and social capital.
Cytokines du système de défense : interleukines et chimiokines (1998)

Les interactions cellulaires au sein du systeme immunitaire se font a la fois par contact direct et par l’intermediaire de mediateurs solubles appeles cytokines. Celles-ci interviennent a tous les stades et dans tous les types de reactions immunitaires, permettant l’amplification, l’orientation puis la regulation des reponses cellulaires et humorales. Elles ont le role de veritables mediateurs paracrines, mais parfois autocrines, de la reaction immunitaire. Ces molecules, aux effets pleiotropiques, s’articulent entre elles au sein d’un reseau complexe ou elles interagissent par des relations de production en cascade, de synergie, d’amplification et de (retro-) inhibition. De nouvelles molecules, les chimiokines et leurs recepteurs, sont recemment venues s’ajouter a ce reseau de mediateurs. Leur connaissance eclaire certaines interactions cellulaires et permet de mieux apprehender l’organisation des systemes de defense dans l’espace et dans le temps. L’objectif de cette revue est de mettre en perspective le role des principales cytokines et chimiokines et de montrer les perspectives d’application clinique et therapeutique que laissent entrevoir les dernieres decouvertes dans ce domaine. Il est possible desormais d’envisager, grâce aux connaissances fondamentales accumulees depuis une dizaine d’annees sur les cytokines, de nouvelles approches diagnostiques et therapeutiques dans de nombreuses pathologies inflammatoires et infectieuses. Il est probable que la fin des annees 90 sera marquee par la validation clinique de methodes de stimulation des reponses immunitaires et, surtout, de reorientation de celles-ci en fonction du but recherche. Il est permis de penser que la prochaine decennie sera marquee, grâce aux connaissances sur les chimiokines et leurs recepteurs, par l’avenement d’outils permettant de modifier la circulation et la distribution dans l’organisme des cellules immunitaires et inflammatoires. Ces techniques permettront d’ameliorer la selectivite de l’immuno-intervention vis-a-vis de certaines reponses immunitaires, voire de certains organes.
Introduction (2002)

“In Progress” provides us with a snapshot of the changing themes in medical education and the creative ways medical school faculty are addressing these events. The title “In Progress” was created for this section of the journal to encourage projects not yet completed, not fully evaluated, and sometimes not even successful. The section is itself a work in progress and continues to evolve and change to reflect the changes facing medical education. When Michael Whitcomb became editor of Academic Medicine he was interested in providing as much information about innovative approaches to medical education as possible. The approach he suggested was to publish the accepted “In Progress” reports several times a year, rather than in a single issue of the journal. This new approach to “In Progress” will allow us to group reports with articles on corresponding themes in the issue of the journal in which both appear. It will allow for a few more reports to be published each year. Perhaps, most importantly, it will give an even better sense of the degree of innovation and change under way in medical education today. We received a record number of submissions for “In Progress” this year. More than 300 reports were sent out to external reviewers. I want to acknowledge the important contributions made by each of the reviewers listed both in shaping the contents of the “In Progress” section and in shaping the direction of the “In Progress.” During the past eight years, the reviewers have provided substantive suggestions for changes in the review process, the review form, and the nature of the “In Progress” section. Without their thoughtful suggestions and their commitment of time and energy to the review process, there would be no feature called, “In Progress.” While I am thanking people, I want to give special mention to the staff of Academic Medicine and to Mike Whitcomb for their support of this section of the journal and their assistance in making it happen. As always, we welcome your comments on “In Progress.”
A constraint-driven solid modeling open environment (1993)

Aprototypa system was designed andimpkmentedto integrate design geometry with the canstraintaimposed by thedeaign pocess in so open geometdc modeling environment. lkign components smrepmemed by objects in anobject-orkntedpogramming (GOP) environment. l%e generation of design models starts liwn the creation of high-level abstractions,i.e. the form features and constraints,to low-level abstractions,i.e. the boundaryrepresentation aolidmodel. Both levels of abstractionsmere.premnteduniformlyby object classes.
Beyond Anaemia Management: Evolving Role of Erythropoietin Therapy in Neurological Disorders, Multiple Myeloma and Tumour Hypoxia Models (2005)

Recombinant human erythropoietin (epoetin) has become the standard of care in the treatment of anaemia resulting from cancer and its treatment, and chronic kidney disease. The discovery that erythropoietin and its receptor are located in regions outside the erythropoietic system has led to interest in the potential role of epoetin in other tissues, such as the central nervous system. Animal studies have shown that systemically applied epoetin can cross the blood-brain barrier, where it reduces tissue injury associated with stroke, blunt trauma and experimental autoimmune encephalomyelitis. Pilot studies in humans have shown that epoetin treatment given within 8 h of stroke reduces infarct size and results in a significantly better outcome when compared with placebo treatment. Studies also suggest that epoetin has the potential to improve cognitive impairment associated with adjuvant chemotherapy in patients with cancer. Anaemia is a major factor causing tumour hypoxia, a condition that can promote changes within neoplastic cells that further tumour survival and malignant progression and also reduces the effectiveness of several anticancer therapies including radiotherapy and oxygen-dependent cytotoxic agents. Use of epoetin to prevent or correct anaemia has the potential to reduce tumour hypoxia and improve treatment outcome. Several therapeutic studies in anaemic animals with experimental tumours have shown a beneficial effect of epoetin on delaying tumour growth. Furthermore, clinical observations in patients with multiple myeloma and animal studies have suggested that epoetin has an antimyeloma effect, mediated via the immune system through activation of CD8+ T cells. Therefore, the role of epoetin may go well beyond that of increasing haemoglobin levels in anaemic patients, although additional studies are required to confirm these promising results.
ChemInform Abstract: PYRAZOLO(5,1‐B)QUINAZOLIN‐9‐ONES: A NEW SERIES OF ANTIALLERGIC AGENTS (1981)

Abstract Die Benzoxazindione (I) reagieren mit dem Dihydropyrazolon (II) unter Ringöffnung zu den Pyrazolochinazolonen (III), die weiter in die Derivate (IV) umgewandelt werden.
More Efficient VLR Group Signature Satisfying Exculpability (2008)

In this letter, we improve NF'07 (Nakanishi and Funabiki) VLR group signature scheme such that it satisfies exculpability and has lower computation costs. In the proposed scheme, a group member generates his own private key together with the group manager in order to realize exculpability while the signature size is not made longer. Also, a new revocation check method is proposed at the step of verifying, and the computation costs of verifying are independent of the number of the revoked members, while they are linear with the number of the revoked members in the original scheme. Thus, the proposed scheme is more efficient than the original scheme and can be applicable to mobile environments such as IEEE 802.1x.
Navigation through Hierarchical Menu Structures: Does it Help to have a Map? (1982)

The human/computer interface for many information retrieval systems is a hierarchical menu structure. Although this type of interface has several advantages for novice users, there is great potential for confusion and disorientation when menu structures are large and complex. This experiment demonstrated that subjects given the opportunity to study a map of the menu organization for a prototype database showed an overall improvement in information retrieval performance across time. Subjects who studied a linear index of correct menu choice sequences showed a general decline in performance as the time between studying the index and new retrieval tasks increased. A control group was slower and made more unnecessary choices than either the map or index group. The results suggest that access to a pictorial representation of a menu structure facilitates the development of a workable, relatively long-lasting mental model of that structure.
Alkaline earth metal-based metal–organic framework: hydrothermal synthesis, X-ray structure and heterogeneously catalyzed Claisen–Schmidt reaction (2014)

Two alkaline earth metal-based carboxylate systems, [Mg(HL)(H2O)2]n (1) and [Ca(H2L)2]n (2) (H3L = chelidamic acid) have been hydrothermally synthesized, and characterized by single-crystal X-ray diffraction, IR, elemental analysis, and thermo-gravimetric analysis. Compound 1 has a 2D structure incorporating two water molecules. The dehydrated species, 1a, generated from 1 by removal of the coordinated water, has been characterized by thermo-gravimetric analysis, IR, elemental analysis and variable temperature powder X-ray diffraction. Both 1 and its dehydrated species 1a catalyze the Claisen-Schmidt reaction under heterogeneous conditions, but 1a is a more effective catalyst under environmentally friendly conditions. The catalyst can readily be recovered and reused in successive cycles without detectable loss of activity. Compound 2 has a 3D structure and is thermally stable up to 540 °C, but is inactive catalytically.
Reactions of carbon monoxide with trimethylsilyl and tris(trimethylsilyl)silyl derivatives of Group 4 metals. Synthesis, characterization, and reactivity of silaacyl complexes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of carbon monoxide with trimethylsilyl and tris(trimethylsilyl)silyl derivatives of Group 4 metals. Synthesis, characterization, and reactivity of silaacyl complexesBrian K. Campion, Jonathan Falk, and T. Don TilleyCite this: J. Am. Chem. Soc. 1987, 109, 7, 2049–2056Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ja00241a023https://doi.org/10.1021/ja00241a023research-articleACS PublicationsRequest reuse permissionsArticle Views558Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Human Nasal Mucosa Contains Tissue-Resident Immunologically Responsive Mesenchymal Stromal Cells (2009)

Multipotent mesenchymal stromal cells (MSC) are present in bone marrow and other tissues such as adipose tissue, muscle, pancreas, liver, and so on. Recent evidence suggests that MSC migrate to sites of infection, inflammation, and cancer, and interact with different immune cell subsets. Here, we report for the first time on the isolation and characterization of multipotent nasal mucosa-derived mesenchymal stromal cells (nm-MSC). nm-MSC showed a plastic adherent and fibroblast-like morphology and were able to form colonies. They expressed the typical bone marrow MSC marker antigens CD29, CD44, CD73, CD90, and CD105 and were able to differentiate along the adipogenic, chondrogenic, and osteogenic pathways. nm-MSC produced a set of inflammatory cytokines, expressed chemokine receptors, and were responsive to stimulation with cytokines, chemokines, and TLR4 ligand LPS. Thus, these cells may serve as an alternative adult stromal cell resource for regenerative tissue repair and may represent important regulators of local mucosal immunity.
Infrequent Occurrence of Natural Mutations in the pp65<sub>495–503</sub>Epitope Sequence Presented by the HLA A∗0201 Allele among Human Cytomegalovirus Isolates (2001)

To determine if mutations of an immunodominant HLA-restricted cytomegalovirus (CMV) peptide sequence occur in nature, the sequence corresponding to the HLA A*0201-specific peptide CMVpp65(495-503) was determined in 50 human CMV isolates. Rare mutations were detected; 6 of 50 were silent mutations at the amino terminus of the peptide, while 3 of 50 were mutations of the native methionine residue to isoleucine (M499I). The observed M499I mutation in three isolates decreased cytolytic targeting.
Identification of a Conserved Interface between PUF and CPEB Proteins (2012)

Members of the PUF (Pumilio and FBF) and CPEB (cytoplasmic polyadenylation element-binding) protein families collaborate to regulate mRNA expression throughout eukaryotes. Here, we focus on the physical interactions between members of these two families, concentrating on Caenorhabditis elegans FBF-2 and CPB-1. To localize the site of interaction on FBF-2, we identified conserved amino acids within C. elegans PUF proteins. Deletion of an extended loop containing several conserved residues abolished binding to CPB-1. We analyzed alanine substitutions at 13 individual amino acids in FBF-2, each identified via its conservation. Multiple single point mutations disrupted binding to CPB-1 but not to RNA. Position Tyr-479 was particularly critical as multiple substitutions to other amino acids at this position did not restore binding. The complex of FBF-2 and CPB-1 repressed translation of an mRNA containing an FBF binding element. Repression required both proteins and was disrupted by FBF-2 alleles that failed to bind CPB-1 or RNA. The equivalent loop in human PUM2 is required for binding to human CPEB3 in vitro, although the primary sequences of the human and C. elegans PUF proteins have diverged in that region. Our findings define a key region in PUF/CPEB interactions and imply a conserved platform through which PUF proteins interact with their protein partners.
Identification of guttation fluid proteins: the presence of pathogenesis‐related proteins in non‐infected barley plants (2003)

The main driving force behind water transport in plants is the air's low water potential. In the presence of high humidity, the transpiration process is halted and water transport is mainly sustained by the root pressure. The surplus of water following the removal of essential components (e.g. salts) is excreted by the plant via guttation through the hydathodes. When guttation occurs, the plant surface is wetted. These are the conditions that will allow epiphytic living, motile bacteria to move and to eventually enter the plant's interior via the hydathodes. The question arose as to whether the plant has developed a protection mechanism against motile bacteria in the vicinity of the hydathodes. Such a protection mechanism could use the well known pathogenesis‐related (PR) proteins. Indeed, an analysis of the guttation fluid using one‐ and two‐dimensional electrophoresis showed a clustering of approximately 200 proteins, primarily with isoelectric points in the acidic pH. Proteins identified using electrospray ionization mass spectroscopic analysis and western blot analysis belong mostly to the family of PR‐proteins suggesting a role in plant protection against invaders. The protein profile of the guttation fluid was remarkably modified by treating plants with methyl jasmonic acid suggesting that the protein composition of the guttation fluid is controlled by internal and/or external stimuli.
Bulk double emulsification for flow cytometric analysis of microfluidic droplets (2017)

Droplet microfluidics is valuable for applications in chemistry and biology, but generates massive numbers of droplets that must be analyzed and sorted. Here, we describe a simple approach to bulk double emulsify microfluidic emulsions for analysis and sorting with commercial flow cytometers. We illustrate the method by using it to identify droplets based on nucleic acid content. Though simple, our method provides a general approach for analyzing and sorting microfluidic droplets without custom microfluidic double emulsifiers or sorters.
Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system (2016)

Dairy Propionibacterium freudenreichii is a candidate non-lactic acid probiotic. However, little information is available on the effect of P. freudenreichii on lifespan extension in humans. The aim of this study was to evaluate the effects of P. freudenreichii on lifespan extension and to elucidate the mechanism of P. freudenreichii-dependent lifespan extension in Caenorhabditis elegans. The results showed that P. freudenreichii significantly (p < 0.05) extended the lifespan of C. elegans compared with Escherichia coli OP50, a standard food for the worm. Analysis of age-related biomarkers showed that P. freudenreichii retards ageing. Moreover, P. freudenreichii increased resistance against a human pathogen, Salmonella typhimurium, through the activation of skn-1, which is involved in pathogen resistance in C. elegans. Furthermore, P. freudenreichii-fed daf-16, jnk-1, skn-1 or daf-7 loss-of-function mutants showed an extended mean lifespan compared with E. coli OP50-fed worms. However, the increase in lifespan was not observed in pmk-1, sek-1, mek-1, dbl-1, daf-12 or daf-2 mutants, which suggests potential roles for these genes in P. freudenreichii-induced longevity in C. elegans. In conclusion, P. freudenreichii extends the lifespan of C. elegans via the p38 MAPK pathway involved in stress response and the TGF-β pathways associated with anti-inflammation processes in the immune system.
Symmetry reduction in group<i>4mm</i>photonic crystals (1997)

The size of absolute band gaps in two-dimensional photonic crystals is often limited by band degeneracies at the lattice symmetry points. By reducing the lattice symmetry, these degeneracies can be lifted to increase the size of existing photonic band gaps, or to create new gaps where none existed for the more symmetric structure. Specifically, symmetry reduction by the addition of different diameter rods into the unit cell of two-dimensional square lattices (Laue group $4mm$) is explored. This approach is especially useful in opening absolute band gaps in structures of dielectric rods in air, which are more easily microfabricated than a crystal of air columns in a dielectric background. Symmetry reduction offers a rational approach for exploring and designing new photonic crystal structures.
Free energy calculations: a breakthrough for modeling organic chemistry in solution (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree energy calculations: a breakthrough for modeling organic chemistry in solutionWilliam L. JorgensenCite this: Acc. Chem. Res. 1989, 22, 5, 184–189Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ar00161a004https://doi.org/10.1021/ar00161a004research-articleACS PublicationsRequest reuse permissionsArticle Views2493Altmetric-Citations558LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Instantaneously Optimized Controller for a Multimode Hybrid Electric Vehicle (2010)

A multimode transmission combines several power-split modes and possibly several fixed gear modes, thanks to complex arrangements of planetary gearsets, clutches and electric motors. Coupled to a battery, it can be used in a highly flexible hybrid configuration, which is especially practical for larger cars. The Chevrolet Tahoe Hybrid is the first light-duty vehicle featuring such a system. This paper introduces the use of a high-level vehicle controller based on instantaneous optimization to select the most appropriate mode for minimizing fuel consumption under a broad range of vehicle operating conditions. The control uses partial optimization: the engine ON/OFF and the battery power demand regulating the battery state-of-charge are decided by a rulebased logic; the transmission mode as well as the operating points are chosen by an instantaneous optimization module that aims at minimizing the fuel consumption at each time step. The controller is then implemented in a Simulink/Stateflow controller that can be used in Argonne's PSAT (Powertrain System Analysis Toolkit), a forward-looking powertrain simulation toolkit with dynamic plant models. As a result, the controller described in this paper is realistically implementable on an actual vehicle. Simulation results show the mode use and describe the practical operations of the system.