gebhart/patrepeval huggingface dataset:
An Anthracene‐Based Fluorescent Sensor for Transition Metal Ions (1994)

Recognition of cations by fluorescence quenching or enhancement has previously been limited to d0 and d10 cations. The fluorescent sensor 1 recognizes CuII and NiII ions in a pH-controlled complexation, in which the amide groups are deprotonated and the fluorescence of the anthracene group is quenched. ZnII and other divalent ions earlier in the 3d series (e.g. MnII and CoII) are not recognized by 1. Since only CuII is chelated by 1 at pH 7, CuII and NiII can be distinguished.
Photochemical reaction of Fe(CO)2(NO)2 and Co(CO)3NO with 1,3-butadiene in liquid xenon solution: possible intermediates in the catalytic dimerization of dienes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical reaction of Fe(CO)2(NO)2 and Co(CO)3NO with 1,3-butadiene in liquid xenon solution: possible intermediates in the catalytic dimerization of dienesGerard E. Gadd, Martyn Poliakoff, and James J. TurnerCite this: Organometallics 1987, 6, 2, 391–397Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/om00145a025https://doi.org/10.1021/om00145a025research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation, characterization and clinical evaluation of a pancreas cancer-associated antigen (1981)

A pancreas cancer-associated antigen (PCAA) was identified and isolated from ascites fluid of human pancreatic cancer. Purified PCAA was homogeneous as determined by polyacrylamide gel electrophoresis. PCAA was a glycoprotein with a molecular weight of approximately 1,000,000 and consisted of 20% carbohydrates and 80% peptides, had an isoelectric point of 4.7, and migrated to alpha 2-beta region. It possessed a sedimentation coefficient of 14S and appeared to be a fibrous or fibroglobular protein. Immunoreactivity of PCAA was sensitive to proteolytic enzymes, perchloric acid, KSCN, glycine-HCl at pH 2.5, urea and lithium diiodosalicylate; and insensitive to neuraminidase or beta-glucosidase. Immunohistochemical technique revealed that PCAA was located in the cytoplasm of ductal epithelial cells of malignant pancreas. Using heteroantiserum raised against purified PCAA, horseradish peroxidase and CNBr-activated Sepharose 4B, an enzyme-immunoassay (EIA) for circulating PCAA has been developed. From a group of 40 healthy blood donors, an upper limit of 16.2 micrograms of PCAA/ml of serum has been tentatively determined. An elevated PCAA was shown in 67% (29/43) of patients with pancreas cancer, as well as in 30% (11/36) of lung cancer patients, 27% (10/37) of colonic cancer patients, and in 16% (6/36) of breast cancer patients. The reactive antigen in sera of these cancers was shown to be immunologically identical. PCAA also was detected in extracts of various human tissues, particularly pancreatic tumors, colonic tumors, and in a normal colon. Further, PCAA exhibited heterogeneity in molecular weight, isoelectric point, and electrophoretic mobility.
Design of a versatile chemical assembly method for patterning colloidal nanoparticles (2009)

Poly(methyl methacrylate) (PMMA) domains in phase-separated polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA) diblock copolymer thin films were chemically modified for controlled placement of solution synthesized Au nanoparticles having a mean diameter of 24 nm. Colloidal Au nanoparticles functionalized with thioctic acid were immobilized on amine functionalized PMMA domains on the PS-b-PMMA template using 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride linking chemistry and N-hydroxy sulfosuccinimide stabilizer. Atomic force microscopy and scanning electron microscopy images demonstrated immobilization of Au nanoparticles commensurate with PMMA domains. Nanoparticles form into clusters of single particles, dimers, and linear chains as directed by the PMMA domain size and shape. Capillary forces influence the spacing between Au nanoparticles on PMMA domains. Inter-particle spacings below 3 nm were achieved and these assemblies of closely spaced nanoparticle clusters are expected to exhibit strong localized electromagnetic fields. Thus, these processes and material systems provide an experimental platform for studying resonantly enhanced excitations of surface plasmons as a function of material and geometric structure as well as utilization in catalytic applications.
Mac OS X Internals (2006)

Mac OS X was released in March 2001, but many components, such as Mach and BSD, are considerably older. Understanding the design, implementation, and workings of Mac OS X requires examination of several technologies that differ in their age, origins, philosophies, and roles.Mac OS X Internals: A Systems Approach is the first book that dissects the internals of the system, presenting a detailed picture that grows incrementally as you read. For example, you will learn the roles of the firmware, the bootloader, the Mach and BSD kernel components (including the process, virtual memory, IPC, and file system layers), the object-oriented I/O Kit driver framework, user libraries, and other core pieces of software. You will learn how these pieces connect and work internally, where they originated, and how they evolved. The book also covers several key areas of the Intel-based Macintosh computers.A solid understanding of system internals is immensely useful in design, development, and debugging for programmers of various skill levels. System programmers can use the book as a reference and to construct a better picture of how the core system works. Application programmers can gain a deeper understanding of how their applications interact with the system. System administrators and power users can use the book to harness the power of the rich environment offered by Mac OS X. Finally, members of the Windows, Linux, BSD, and other Unix communities will find the book valuable in comparing and contrasting Mac OS X with their respective systems.Mac OS X Internals focuses on the technical aspects of OS X and is so full of extremely useful information and programming examples that it will definitely become a mandatory tool for every Mac OS X programmer.
Effect of High Influent Sulfate on Anaerobic Wastewater Treatment (2005)

A laboratory-scale study was conducted using a completely mixed reactor with a constant influent-total-organic carbon (TOC) of 3750 mg/L to evaluate the effect of increasing influent-sulfate levels on anaerobic-treatment performance. The sulfate levels were increased stepwise from 333 to 666, 1000, 1333 and 1666 mg S/L. The results showed that an elevation of influent sulfate actually increased the TOC removal efficiency as long as the produced sulfide level did not induce toxicity. At 1333 mg S/L influent sulfate, the produced dissolved sulfide was 613 mg S/L (free sulfide = 228 mg S/L), which started to impose toxicity to the methane-producing bacteria (MPB). It was also found that the percent electron flow to the sulfate-reducing pathway increased with the increasing influent sulfate, but the direction toward the methanogenesis was correspondingly reduced. Nevertheless, under the experimental conditions tested, the majority of the influent organics was still degraded through the methanogenic pathway. Through this study, an oxidation-reduction-potential (ORP)-based oxygenation process was developed for online oxidation of sulfide in recirculating biogas. With controlled oxygen injection to raise the reactor's ORP by 25 mV, the residual sulfide in the reactor was almost totally eliminated. In case of over oxygenation, any excess oxygen was quickly consumed by the facultative organisms in the reactor, thereby imposing no toxicity to the MPB.
The Electrochemistry of the Leaching Reactions in the Caron Process. I. Anodic Processes (2006)

The Caron process involves the oxidative dissolution of pre-reduced iron alloys containing nickel, cobalt and copper in ammoniacal carbonate solutions. This study has demonstrated that passivation is exhibited by nickel and cobalt at higher potentials than previously established for iron. It is shown that alloys of iron with nickel and cobalt also undergo passivation at low potentials resulting in inhibition of the dissolution of the valuable metals. The potential regions of active dissolution of each of these metals in ammonia-ammonium carbonate solutions have been established. The effect of thiosulphate and cobaltammine complex ions on the dissolution of iron and nickel was found to be significant in that thiosulphate appears to partially prevent the passivation of nickel while the presence of cobaltammine ions leads to lower apparent anodic current densities. Possible mechanisms for the passivation processes and for the effects of thiosulfate and cobaltammines on the dissolution are presented.
Controlled evaluation of BacT/Alert standard aerobic and FAN aerobic blood culture bottles for detection of bacteremia and fungemia (1995)

A new medium, FAN, designed to enhance the recovery of microorganisms, has been developed for the BacT/Alert blood culture system (Organon Teknika Corp., Durham, N.C.). We compared the yield and speed of detection of microorganisms in 6,847 adequately filled paired aerobic standard and FAN bottles at four university hospitals. Of 499 clinically significant microorganisms isolated from one or both bottles, significantly more Staphylococcus aureus isolates (P < 0.001), coagulase-negative staphylococci (P < 0.001), yeasts (P < 0.01), and all microorganisms combined (P < 0.001) were recovered from the FAN bottles. Overall, the speeds of detection of positive cultures did not differ between the two medium formulations; mean times to detection in the standard and FAN bottles were 16.1 and 16.0 h, respectively. When a subset of patients on antimicrobial therapy was evaluated, significantly enhanced yield from the FAN bottle was evident for staphylococci. Overall, the FAN bottle outperformed the standard aerobic BacT/Alert bottle.
Changes in the synthesis, distribution and sulphation of glycosaminoglycans of cultured human skin fibroblasts upon ascorbate feeding (1983)

The effect of ascorbic acid on the synthesis, distribution and sulphation of glycosaminoglycans by human skin fibroblasts has been examined. Medium was supplemented with ascorbate over several days, and cultures incubated with [3H]glucosamine and Na2(35)SO4 for 48 h, followed by analysis of the glycosaminoglycans in the medium, in collagenase and trypsin extracts, and in cell fractions. Ascorbate feeding resulted in a reduction in hyaluronate synthesis, which was the main 3H-labelled component and was distributed mainly in the medium fractions. Sulphated glycosaminoglycans showed a reduction in incorporation of 3H label, but increased sulphation following ascorbate feeding. In control cultures 53% of 3H-labelled sulphated glycosaminoglycans and 63% of 35S-labelled glycosaminoglycans were present in the medium fraction, while in ascorbate-fed cultures, 41% of 3H label and 38% 35S label were incorporated into medium-sulphated glycosaminoglycans. Ascorbate also caused an increase in cell density and in collagen production and deposition.
From In-Place Updates to In-Place Appends (2017)

Under update intensive workloads (TPC, LinkBench) small updates dominate the write behavior, e.g. 70% of all updates change less than 10 bytes across all TPC OLTP workloads. These are typically performed as in-place updates and result in random writes in page-granularity, causing major write-overhead on Flash storage, a write amplification of several hundred times and lower device longevity.
Interaction between DNA Gyrase and Quinolones: Effects of Alanine Mutations at GyrA Subunit Residues Ser <sup>83</sup> and Asp <sup>87</sup> (2001)

DNA gyrase is a target of quinolone antibacterial agents, but the molecular details of the quinolone-gyrase interaction are not clear. Quinolone resistance mutations frequently occur at residues Ser(83) and Asp(87) of the gyrase A subunit, suggesting that these residues are involved in drug binding. Single and double alanine substitutions were created at these positions (Ala(83), Ala(87), and Ala(83) Ala(87)), and the mutant proteins were assessed for DNA supercoiling, DNA cleavage, and resistance to a number of quinolone drugs. The Ala(83) mutant was fully active in supercoiling, whereas the Ala(87) and the double mutant were 2.5- and 4- to 5-fold less active, respectively; this loss in activity may be partly due to an increased affinity of these mutant proteins for DNA. Supercoiling inhibition and cleavage assays revealed that the double mutant has a high level of resistance to certain quinolones while the mutants with single alanine substitutions show low-level resistance. Using a drug-binding assay we demonstrated that the double-mutant enzyme-DNA complex has a lower affinity for ciprofloxacin than the wild-type complex. Based on the pattern of resistance to a series of quinolones, an interaction between the C-8 group of the quinolone and the double-mutant gyrase in the region of residues 83 and 87 is proposed.
RELATIVE EFFECTIVENESS OF VARIOUS STEROIDS IN AN ANDROGEN ASSAY USING THE EXORBITAL LACRIMAL GLAND OF THE CASTRATED RAT. (1967)

ABSTRACT Morphological studies have shown that the exorbital lacrimal gland of the albino rat is a sexually dimorphic structure highly sensitive to androgens. Testosterone treatment elicits a vesicular-mucous change in the glandular acini which can be quantitated histologically and appears to be closely related to the administered dose. An assay procedure using the vesicular change as the end-point of androgenic activity is described and the relative androgenic activities of twenty-one Δ 4 -3-keto- and Δ 5 -3β-hydroxysteroids are given. The effect of a variety of substitutions in the steroid nucleus on the activities of testosterone, 17α-methyl-testosterone and 19-nortestosterone is described and discussed with reference to previously reported data.
Accelerated arteriosclerosis in heart transplant recipients is associated with a T-lymphocyte-mediated endothelialitis. (1990)

Accelerated arteriosclerosis has emerged as a major life-threatening complication in long-term survivors of heart transplantation. It has been proposed that accelerated arteriosclerosis is an immune-mediated complication of rejection. We observed a striking endothelialitis in the coronary arteries of two explanted hearts obtained from patients with severe transplant-related accelerated arteriosclerosis. This finding prompted us to review the pathologic changes in the coronary arteries of 23 autopsied patients who had received heart transplants. The infiltrate in these vessels was characterized using immunohistochemical stains for lymphocytes (CD45), macrophages (MAC-387), T lymphocytes (CD45RO), B lymphocytes (L-26), and smooth muscle cells (actin). In addition, a full panel of monoclonal antibodies was used on the fresh-frozen tissue available from one of the two explanted hearts. Ten of the eleven recipients with accelerated arteriosclerosis had a moderate to marked lymphocytic endothelialitis compared to 3 of 14 without transplant-related arteriosclerosis (P less than 0.005). Immunohistochemical staining of the paraffin-embedded material demonstrated that most of the lymphocytes in the subendothelial space of these vessels were T lymphocytes and that this infiltrate was associated with an accumulation of macrophages and a proliferation of smooth muscle cells in the intima. In the explanted heart from which fresh-frozen tissue was available for more detailed cell typing, the T cells marked predominantly as cytotoxic T lymphocytes (CD8+, CD2+). These results suggest that accelerated arteriosclerosis may be mediated, in part, by a cytotoxic T-lymphocyte-directed endothelialitis.
Gas-sampling technique for arsenic determination by atomic absorption spectrophotometry (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-sampling technique for arsenic determination by atomic absorption spectrophotometryWalter. HolakCite this: Anal. Chem. 1969, 41, 12, 1712–1713Publication Date (Print):October 1, 1969Publication History Published online1 May 2002Published inissue 1 October 1969https://pubs.acs.org/doi/10.1021/ac60281a025https://doi.org/10.1021/ac60281a025research-articleACS PublicationsRequest reuse permissionsArticle Views834Altmetric-Citations187LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synchrotron infrared imaging of advanced glycation endproducts (AGEs) in cardiac tissue from mice fed high glycemic diets (2013)

Recent research findings correlate an increased risk for dieases such as diabetes, macular degeneration and cardiovascular disease (CVD) with diets that rapidly raise the blood sugar levels; these diets are known as high glycemic index (GI) diets which include white breads, sodas and sweet deserts. Lower glycemia diets are usually rich in fruits, non-starchy vegetables and whole grain products. The goal of our study was to compare and contrast the effects of a low vs. high glycemic diet using the biochemical composition and microstructure of the heart. The improved spatial resolution and signal-to-noise for SR-FTIR obtained through the coupling of the bright synchrotron infrared photon source to an infrared spectral microscope enabled the molecular-level observation of diet-related changes within unfixed fresh frozen histologic sections of mouse cardiac tissue. High and low glycemic index (GI) diets were started at the age of five-months and continued for one year, with the diets only differing in their starch distribution (high GI diet = 100% amylopectin versus low GI diet = 30% amylopectin/70% amylose). Serial cryosections of cardiac tissue for SR-FTIR imaging alternated with adjacent hematoxylin and eosin (H&E) stained sections allowed not only fine-scale chemical analyses of glycogen and glycolipid accumulation along a vein as well as protein glycation hotspots co-localizing with collagen cold spots but also the tracking of morphological differences occurring in tandem with these chemical changes. As a result of the bright synchrotron infrared photon source coupling, we were able to provide significant molecular evidence for a positive correlation between protein glycation and collagen degradation in our mouse model. Our results bring a new insight not only to the effects of long-term GI dietary practices of the public but also to the molecular and chemical foundation behind the cardiovascular disease pathogenesis commonly seen in diabetic patients.
TEST °c R.............. (2000)

ATMER 121. Glycerol oleate, paste is an excellent antifog for PVC food-wrapping film alone or in combination with Atmer 116. It also imparts adhesion properties (cling effect to the film).ATMER 122-129. GMS, solid, excellent for LDPE, imparts antistatic effect.
Disinfection of Sewage Effluent with Peracetic Acid (1989)

Novel products based on peracetic acid (PAA) have recently been developed for the disinfection of sewage and sewage effluents. The efficacy of such products has been assessed under both laboratory and operational conditions. Comparative laboratory studies of the effects of peracetic acid, chlorine dioxide and chlorine on indicator bacteria in secondary sewage effluent have shown peracetic acid to be a viable alternative to these halogen biocides. In a trial carried out at two small rural works, PAA was dosed into secondary effluent from either an activated sludge plant or a percolating filter bed prior to tertiary lagoon treatment. LOW levels of PAA greatly enhanced the natural decline in coliform levels across the lagoon, enabling much lower concentrations of bacteria to be discharged into the receiving streams. In another trial, secondary effluent from an activated sludge plant was treated before discharge into a stream leading to the sea. Coliform concentrations were greatly reduced along the watercourse downstream from the plant.
Cytotoxicity of ICD-85 NPs on Human Cervical Carcinoma HeLa Cells through Caspase-8 Mediated Pathway. (2013)

The biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. The cytotoxicity was evaluated by MTT and LDH assays. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using caspase-8 colorimetric assay. The MTT assay showed that ICD-85 NPs could enhance the in-vitro cytotoxicity against HeLa cells compared to the free ICD-85. The IC50 value at 72 h was reduced from 25 ± 2.9 μg/mL for free ICD-85 to 15.5 ± 2.4 μg/mL for ICD-85 NPs. However, LDH assay demonstrated that ICD-85 has dose-dependent cytotoxicity on HeLa cells while ICD-85 NPs exhibited weaker cytotoxicity on same cells. The results also indicate that ICD-85-induced apoptosis on HeLa cells is associated with the activation of caspase-8. Moreover, caspase-8 assay analysis demonstrated that the ICD- 85 NPs induced a higher apoptotic rate in HeLa cells compared to free ICD-85. Our results demonstrated that the encapsulation of ICD-85 enhances its anti-proliferative effects. Taken together, these results suggest that the delivery of ICD-85 in nanoparticles may be a promising approach for the treatment of the cancer.