gebhart/patrepeval huggingface dataset:
Electrochemically Driven Formation of a Molecular Capsule around the Ferrocenium Ion (2002)

Electrochemical experiments were used to show that the oxidation of ferrocene triggers the self-assembly of six molecules of the resocin[4]arene 2 to form a molecular capsule around the oxidized, ferrocenium (+1) form. The nature of the supporting electrolyte anion is crucial for this process of electrochemically driven self-assembly. 1H NMR spectroscopic data obtained with cobaltocenium, a diamagnetic analogue of the paramagnetic ferrocenium ion, verify its encapsulation by six molecules of 2. The encapsulation of cobaltocenium was also observed in voltammetric experiments. Encapsulation of ferrocenium (or cobaltocenium) inside the large 26 capsule led to a dramatic slowing of its usually fast, one-electron electrochemical reduction to ferrocene (or cobaltocene).
The preparation,quality control and clinical application of rongsheng bolus (2011)

Objective To introduce the preparation,quality control and clinical application of Rongsheng bolus.Methods To set up negative control and make qualitative identification by thin layer chromatography(TLC) and to conduct clinical trial without control group.Results Every indicator of Rongsheng bolus conforms to the criterion,and the stability of the bolus is good.The total effective rate of the clinical trial is 81%.Conclusion The methods of the preparation and quality control are simple and convenient with a low price and a reliable therapeutic effect.
Acoustic fall detection using a circular microphone array (2010)

Falling is a common health problem for elderly. It is reported that more than one third of adults 65 and older fall each year in the United States. To address the problem, we are currently developing an acoustic fall detection system, FADE, which automatically detects a fall and reports it to the caregiver. In a previous version, FADE used a 3-microphone linear array to eliminate the false alarms produced by sounds produced well above the floor level. To improve the fall detection in noisy and reverberant environments, we replaced the linear array by an 8-microphone circular array that can provide a better 3-D estimation of the sound location. Preliminary experiments show that the sound location estimation performed by the circular array is reliable and robust to interference. We obtained encouraging classification results on a pilot dataset with 55 falls and 120 non-fall sounds.
<title>Cyber agent on the World Wide Web</title> (1996)

The World Wide Web has brought the information from a distributed environment into a global information universe. As users keep on surfing the Web and adding their bookmarks, it is increasingly difficult for them to find their desired information even though there are many search tools available. In this paper, a smart engineering system called Cyber Agent is proposed to help users search and organize the information. It contains two major subsystems, namely, WebTracer and WebOrganizer. They adapt their behavior dynamically according to the environment and the special preferences of each individual. WebTracer is the wavefront of the Cyber Agent while WebOrganizer is the brain of the Cyber Agent.
Dual-action penems and carbapenems (1992)

Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of <i>Plasmodium falciparum</i> (2007)

Recombinant N-myristoyltransferase of Plasmodium falciparum (termed PfNMT) has been used in the development of a SPA (scintillation proximity assay) suitable for automation and high-throughput screening of inhibitors against this enzyme. The ability to use the SPA has been facilitated by development of an expression and purification system which yields considerably improved quantities of soluble active recombinant PfNMT compared with previous studies. Specifically, yields of pure protein have been increased from 12 microg x l(-1) to >400 microg x l(-1) by use of a synthetic gene with codon usage optimized for expression in an Escherichia coli host. Preliminary small-scale 'piggyback' inhibitor studies using the SPA have identified a family of related molecules containing a core benzothiazole scaffold with IC50 values <50 microM, which demonstrate selectivity over human NMT1. Two of these compounds, when tested against cultured parasites in vitro, reduced parasitaemia by >80% at a concentration of 10 microM.
Effect of multislice acquisition on T<sub>1</sub> and T<sub>2</sub> measurements of articular cartilage at 3T (2007)

This study demonstrated that the adaptation of multislice acquisition technique for T1 measurement using FSE-IR methodology is difficult and its use for clinical evaluation is problematic. In contrast, multislice acquisition for T2 measurement using MSE was clinically applicable if inaccuracies caused by multislice acquisition were taken into account.
FANTASTIC‐5G: flexible air interface for scalable service delivery within wireless communication networks of the 5th generation (2016)

Abstract 5th generation mobile networks will have to cope with a high degree of heterogeneity in terms of services, mobility, number of devices and so on. Thus, diverse and often contradicting key performance indicators need to be supported, but having multiple radio access technologies for multi‐service support below 6 GHz will be too costly. FANTASTIC‐5G will develop a new multi‐service air interface through a modular design. To allow the system to adapt to the anticipated heterogeneity, some properties need to be pursued, like simplicity, flexibility, scalability, versatility, efficiency and future proofness. Based on these properties, a selected set of use cases and link and network design will be presented. The paper will also comprise validation and system level simulations through some indicative results and will conclude with the overall impact to 5G standardisation. Copyright © 2016 John Wiley & Sons, Ltd.
Clinical Experience with Recombinant Factor VIla in Patients with Thrombocytopenia (1996)

Platelets play a central role in primary hemostasis. The role of the coagulation mechanism during early stages of hemostasis is less clear, although increasing evidence is emerging indicating the ultimate importance of the factor VII (FVII)-tissue factor-dependent coagulation system in providing the first thrombin molecules necessary for the platelet activation to occur. Supporting this, early fibrin formation has been reported to occur within the bleeding time wound and infusion of recombinant FVIIa (rFIIa) has been shown to shorten the bleeding time in rabbits. We have investigated whether infusion of rFVIIa would enhance fibrin formation in bleeding time wounds in patients with thrombocytopenia as reflected by a shortening of the bleeding time. A reduction of the bleeding time was found in 55/105 cases (52%). The decrease was significantly more pronounced when the platelet count exceeded 20 x 10(9)/l. With the exception of an anaphylactoid reaction in 1 patient, no major adverse reactions related to the study drug were observed. Nine infusions of rFVIIa were given to 8 thrombocytopenic patients with overt bleeding. One patient received two infusions. Bleeding decreased in all patients and stopped in 6 patients.
Computer Architecture with Associative Processor Replacing Last-Level Cache and SIMD Accelerator (2014)

This study presents a computer architecture, where a last-level cache and a SIMD accelerator are replaced by an associative processor. Associative processor combines data storage and data processing, and functions as a massively parallel SIMD processor and a memory at the same time. An analytic performance model of this computer architecture is introduced. Comparative analysis supported by cycle-accurate simulation and emulation shows that this architecture may outperform a conventional computer architecture comprising a SIMD coprocessor and a shared last-level cache while consuming less power.
Polarized Fluorescence of Dyes Oriented in Room Temperature Nematic Liquid Crystals (1973)

Abstract Pleochroic absorption and polarized fluorescence of guest molecules oriented in nematic liquid crystals were observed in the nematic phase and at the nematic-isotropic phase transition. The order parameters calculated from fluorescence intensities were found to be smaller than those calculated from the absorption coefficients. For some guest-host combinations a change in the quantum yield of the fluorescence was observed at the nematic-isotropic transition point.
Renal mitochondrial impairment is attenuated by AT<sub>1</sub>blockade in experimental Type I diabetes (2007)

To investigate whether ANG II type 1 (AT(1)) receptor blockade could protect kidney mitochondria in streptozotocin-induced Type 1 diabetes, we treated 8-wk-old male Sprague-Dawley rats with a single streptozotocin injection (65 mg/kg ip; STZ group), streptozotocin and drinking water containing either losartan (30 mg.kg(-1).day(-1); STZ+Los group) or amlodipine (3 mg.kg(-1).day(-1); STZ+Amlo group), or saline (intraperitoneally) and pure water (control group). Four-month-long losartan or amlodipine treatments started 30 days before streptozotocin injection to improve the antioxidant defenses. The number of renal lesions, plasma glucose and lipid levels, and proteinuria were higher and creatinine clearance was lower in STZ and STZ+Amlo compared with STZ+Los and control groups. Glycemia was higher in STZ+Los compared with control. Blood pressure, basal mitochondrial membrane potential and mitochondrial pyruvate content, and renal oxidized glutathione levels were higher and NADH/cytochrome c oxidoreductase activity was lower in STZ compared with the other groups. In STZ and STZ+Amlo groups, mitochondrial H(2)O(2) production rate was higher and uncoupling protein-2 content, cytochrome c oxidase activity, and renal glutathione level were lower than in STZ+Los and control groups. Mitochondrial nitric oxide synthase activity was higher in STZ+Amlo compared with the other groups. Mitochondrial pyruvate content and H(2)O(2) production rate negatively contributed to electron transfer capacity and positively contributed to renal lesions. Uncoupling protein-2 content negatively contributed to mitochondrial H(2)O(2) production rate and renal lesions. Renal glutathione reduction potential positively contributed to mitochondria electron transfer capacity. In conclusion, AT(1) blockade protects kidney mitochondria and kidney structure in streptozotocin-induced diabetes independently of blood pressure and glycemia.
Differential scanning calorimetric study of the thermal unfolding of Taka-amylase A from Aspergillus oryzae (1987)

The thermally induced unfolding of Taka-amylase A, isolated from Aspergillus oryzae, was studied by differential scanning calorimetry. The experimental curves of excess apparent specific heat vs. temperature showed a single asymmetric peak. Curve resolution indicated that this asymmetry is due to the two-state unfolding of three domains in the molecule, with dissociation of the single tightly bound Ca2+ ion occurring during the unfolding of the last domain. Further indication of the dissociation of the specifically bound Ca2+ during denaturation is afforded by the fact that the temperature of maximal excess specific heat, tm, increases with increasing protein concentration in the absence of added excess Ca2+ and with increasing Ca2+ concentration in the presence of added Ca2+. Experiments in a variety of buffers with different enthalpies of ionization indicated that 11.8 +/- 1.5 protons are lost from the protein during unfolding at pH 7.0. In apparent contradiction of this result, the value of tm was found to be essentially independent of pH in the range pH 7-8. No explanation of this anomaly is available. The enthalpy of unfolding at pH 7 and 62 degrees C in the absence of added Ca2+, corrected for the change in buffer protonation, is 2250 +/- 40 kJ mol-1 (42.5 J g-1), and the permanent change in apparent heat capacity is 36.4 +/- 4.1 kJ K-1 mol-1 (0.687 J g-1). Both of these quantities are unusually large for a globular protein.
Plasma-ion-assisted coatings for 15 femtosecond laser systems (2014)

Large-aperture deposition of high-laser-damage-threshold, low-dispersion optical coatings for 15 femtosecond pulses have been developed using plasma-ion-assisted electron-beam evaporation. Coatings are demonstrated over 10 in. aperture substrates.
Ultraschallmotoren mit piezoelektrischem Antrieb (1991)

Abstract Für das Auge unsichtbare, mikroskopisch kleine mechanische Schwingungsbewegungen eines Piezoschwingers treiben zwei Zentimeter große Rotoren zu mehreren hundert Umdrehungen pro Minute an. Solche Antriebe stellen eine interessante Alternative zu herkömmlichen Elektromotoren dar. Sie sind besonders trägheitsarm, laufen mit variabler Drehfrequenz von‐ und rückwärts und sind frei von Magnetfeldern.
Beginning iPad Development for iPhone Developers (2010)

It's in magazines and newspapers, it's on television and radio, it's on buses and billboards and pretty much everywhere you look. The iPad is the touchscreen tablet from Apple, representing the next g
Patient, caregiver, and oncologist perceptions of cancer-related fatigue: results of a tripart assessment survey. The Fatigue Coalition. (1997)

Although fatigue is the most common symptom reported by cancer patients and has serious adverse effects on quality of life, it remains poorly understood. A survey was designed to characterize the epidemiology of cancer-related fatigue from the perspectives of the patient, primary caregiver, and oncologist. A telephone survey included 419 cancer patients recruited from 100,000 randomly selected households nationwide. Patients provided access to 200 primary caregivers (usually family members) who were also interviewed by telephone. In a separate mail survey, 197 of 600 randomly sampled oncologists (unrelated to the patients) responded to a questionnaire that assessed perceptions and attitudes concerning fatigue in cancer patients who had received chemotherapy or radiotherapy and their caregivers. The median patient age was 65 years, and the principal cancer diagnoses were breast (females) and genitourinary (males). Fifty-nine percent of the patients had received chemotherapy, 63% radiation therapy, and 24% both; 20% of patients received their last treatment within 6 weeks, 31% within 7 weeks to 1 year, and 49% more than 1 year ago. More than three quarters of patients (78%) experienced fatigue (defined as a general feeling of debilitating tiredness or loss of energy) during the course of their disease and treatment. Thirty-two percent experienced fatigue daily, and 32% reported fatigue significantly affected their daily routines. Caregivers reported observing fatigue in 86% of the index patients, and oncologists perceived that 76% of their patients experienced fatigue. Although oncologists believed that pain adversely affected their patients to a greater degree than fatigue (61% v 37%), patients felt that fatigue adversely affected their daily lives more than pain (61% v 19%). Most oncologists (80%) believed fatigue is overlooked or undertreated, and most patients (74%) considered fatigue a symptom to be endured. Fifty percent of patients did not discuss treatment options with their oncologists, and only 27% reported that their oncologists recommended any treatment for fatigue. When used, treatments for fatigue were generally perceived by patients and caregivers to be successful. These data confirm the high prevalence and adverse impact of cancer-related fatigue, although it is seldom discussed and infrequently treated. For patients and oncologists, improving the quality of life of cancer patients requires a heightened awareness of fatigue, a better understanding of its impact, and improve communication and familiarity with interventions that can reduce its debilitating effects.
Dense heterogeneous integration for InP Bi-CMOS technology (2009)

InP Bi-CMOS technology capable of wafer-scale device-level heterogeneous integration (HI) of InP HBTs and CMOS has been developed. With this technology, full simultaneous utilization of III-V device speed and CMOS circuit complexity is possible. Simple ICs and test structures have been fabricated, showing no significant CMOS or HBT degradation and high heterogeneous interconnect yield. The heterogeneously integrated differential amplifiers with record performance and HBTs with f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> =400 GHz were obtained. Thermal vias to the Si substrate provide sufficient heat path to lower HI HBT thermal resistances close to on-InP values. Resulting circuits maintain maximum CMOS integration density and HBT performance, while keeping the heterogeneous interconnect length below 5 mum.
Carbon diffusion in silicon (1998)

Carbon diffusion in silicon has been investigated by using a superlattice structure of carbon spikes (10 nm-wide, carbon concentration &gt;1019 cm−3, spikes spaced 100 nm apart) grown epitaxially by Si molecular beam epitaxy. Samples were annealed in the range between 680 and 850 °C. The diffusive behavior of carbon was monitored by secondary ion mass spectrometry. Carbon diffusion profiles observed at temperatures above 800 °C show highly nonregular behavior. The diffusion results are interpreted in terms of the kick-out mechanism.
Identification and Analysis of a Functional Human Homolog of the <i>SPT4</i> Gene of <i>Saccharomyces cerevisiae</i> (1996)

Spt4p is a nonhistone protein of Saccharomyces cerevisiae that is believed to be required for normal chromatin structure and transcription. In this work we describe the isolation and analysis of a human gene, SUPT4H, that encodes a predicted protein 42% identical to Spt4p. When expressed in S. cerevisiae, SUPT4H complemented all spt4 mutant phenotypes. In human cells SUPT4H encodes a nuclear protein that is expressed in all tissues tested. In addition, hybridization analyses suggest that an SUPT4H-related gene is also present in mice. SUPT4H was localized to human chromosome 17 by PCR analysis of a human-rodent somatic cell hybrid panel. Thus, like other proteins that are components of or control the structure of chromatin, Spt4p appears to be conserved from S. cerevisiae to mammals.
Limitation of WSix/WN Diffusion Barrier for Tungsten Dual Polymetal Gate Memory Devices (2007)

We compared WSix/WN and Ti/WN diffusion barriers for tungsten dual polymetal gate (W-DPG) application, in terms of device performance and gate oxide reliability. WSix/WN diffusion barrier shows degradation of gate oxide, which is found to be due to the B-N dielectric formation and subsequent breakdown of diffusion barrier. Relatively, Ti/WN diffusion barrier shows excellent device performance in terms of R/O delay and gate oxide reliability.
Pink esthetics in periodontics – Gingival depigmentation: A case series (2012)

Smile expresses a feeling of joy, success, sensuality, affection, and courtesy, and reveals self-confidence and kindness. The harmony of the smile is determined not only by the shape, the position, and the color of the teeth, but also by the gingival tissues. Although melanin pigmentation of the gingiva is completely benign and does not present a medical problem, complaints of "black gums" are common, particularly in patients having a very high smile line. Thus, perio-esthetic treatment modalities strive to achieve a harmonious inter-relationship of the pink with white, which is imperative of all treatment procedures. For depigmentation of gingival, different treatment modalities have been reported, such as bur abrasion, scraping, partial thickness flap, cryotherapy, electrosurgery, and laser. In the present case series, scraping, electrosurgery, and diode laser have been tried for depigmentation, which are simple, effective, and yield good results, along with good patient satisfaction.
Diacetylated Derivatives of Spermine and Spermidine as Novel Promising Tumor Markers (2006)

N1,N12-diacetylspermine (DiAcSpm) and N1,N8-diacetylspermidine (DiAcSpd) are minor components of human urinary polyamine to which little attention has been paid until recently. HPLC analysis of urinary polyamines has revealed that the excretion of these diacetylpolyamines, in particular, into urine was frequently and markedly increased in association with every type of cancer so far examined. Remission was usually accompanied by recovery of urinary diacetylpolyamines to the normal level. DiAcSpm was more sensitive than CEA for detecting colorectal cancer patients, while DiAcSpd was highly specific for malignant conditions in that the excretion of the latter was scarcely elevated in cases of benign urogenital diseases. An ELISA procedure for rapid determination of DiAcSpm was developed to promote the clinical application of these new tumor markers, and subsequent studies indicated that DiAcSpm was elevated in 60% of colorectal cancer patients at early stages (stage 0 + I), whereas only 10% of these patients were CEA-positive. DiAcSpm may also be useful as a follow-up marker that is efficient for detecting recurrence and sensitive to changes in the clinical condition of patients. The evidence accumulated so far indicates that DiAcSpm and DiAcSpd are promising novel tumor markers. They deserve more intensive studies, including studies of their biochemistry and metabolism.
Psychosocial Treatments for Cocaine Dependence: National Institute on Drug Abuse Collaborative Cocaine Treatment Study (1999)

Compared with professional psychotherapy, a manual-guided combination of intensive individual drug counseling and GDC has promise for the treatment of cocaine dependence.
The sinusoidal transform coder at 2400 b/s (2003)

A structure similar to a subband coder, that evolved in an attempt to improve the performance of the sinusoidal transform coder (STC) in the presence of channel errors, is described. Using some new ideas for subband coding, such as vector quantization of the subband energies and adaptive bit allocation based on the decoded energies, a novel quantization algorithm for STC evolved that was not only more robust in channel errors, but led to improved quality, particularly at the 2400 b/s data rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Phase correlation between longitudinal modes in semiconductor self-pulsating DBR lasers (2005)

Phase correlation leading to self-pulsation (SP) in semiconductor distributed Bragg reflector (DBR) lasers is investigated experimentally and theoretically. Under proper biasing conditions, the laser oscillates with three main modes and we observe that each two-modes beating provides SP with identical spectral linewidth. Under the same operating conditions, the measured spectral linewidths of the beating modes are much larger than the linewidth of the self-pulsating signal. These results demonstrate the natural occurrence of passive mode-locking (PML) and phase correlation in semiconductor DBR lasers. A model based on multimode coupled-wave rate equations, including four-wave mixing (FWM), is developed to describe PML and SP in the gain region of the laser cavity. This model demonstrates that the existence of phase correlation between longitudinal modes is due to FWM.