gebhart/patrepeval huggingface dataset:
ELECTROCARDIOGRAPHIC FINDINGS IN ADOLESCENTS AT REST AND AT MAXIMAL EXERTION (1969)

The electrocardiographic patterns of 152 adolescents at rest and at maximal exercise were obtained. This included both sexes in approximately equal numbers. At rest, most exhibited sinus arrhythmia, a mean QRS frontal plane vector from 0 to +90°, and a resting rate from 80 to 90 per minute. The response to exercise was consistently that of tachycardia, reaching a rate from 180 to 220 per minute. All subjects did not attain a rate of 200 per minute, but several exceeded this. Changes in the T wave morphology with exercise were common and consisted of an increase in amplitude with peaking. Sex differences were noted in that girls had a slightly faster resting rate, required a shorter time to reach maximal exercise, had more rapid duration of exercise, and had faster recovery rates. Also, more girls than boys had an electrical axis of greater than 90°.
Viral Double-Stranded RNA, Cytokines, and the Flu (2000)

The symptoms of the flu, such as fever, drowsiness, and malaise, are the sole means by which this common clinical syndrome is defined. The syndrome is usually the first clinical manifestation of both acute bacterial and viral infections. In the case of acute bacterial infections, several proinflammatory cytokines induced by bacterial products have been implicated as the causative agents of the flu syndrome. Viruses induce similar cytokines to bacteria, plus substantial amounts of interferon-alpha (IFN-alpha), although the direct association of these cytokines with the viral flu syndrome is less clear. Furthermore, the viral inducer(s) of cytokines has not been defined. The best candidate cytokine inducer associated with a majority of viral infections is virus-associated double-stranded RNA (dsRNA). This review examines the essential physical properties of toxic dsRNA, the cytokines induced by it, its viral and cellular sources, evidence for its presence in infected cells, its quantities in normal and infected cells, its cytotoxic mechanisms, and its cell-penetration properties. Toxic effects of viruses and dsRNA are compared. Energetics and extraction artifact issues are also discussed. Whereas most research on dsRNA toxicity has employed synthetic dsRNA, studies with virus-associated dsRNA are featured when available. Finally, a model for how viral dsRNA might initiate systemic disease is presented.
Treatment of chronic pain: the Center for Pain Studies, Rehabilitation Institute of Chicago. (1981)

The Center for Pain Studies of the Rehabilitation Institute of Chicago (formerly known as the Low Back and Pain Clinic) has developed a multidisciplinary program for the management of chronic pain. Typically patients present a variety of chronic pain syndromes, most frequently low back pain, which have not responded to previous treatment including surgery, physical therapy, medication, vogue therapies, and other pain management programs. Patient capability to engage in normal daily activities such as standing, walking, sitting, lifting, etc. is often limited; most are unable to work or carry on pre-injury activities. Psychological ramifications of chronic pain appear frequently as a retreat from responsibility by the patient for his own welfare, manifested by distinct behaviour patterns (measurable on the MMPI); however, the ability of the patient to cope with chronic pain is largely a function of his ability to cope with other stresses prior to onset of pain. The patient's physical and psychological status alters his relationships with spouse and children, straining family well-being. Economic factors often occasion additional alteration in personal and family relations. Frequently a spouse not employed outside the home goes to work. Compensation programs and aid from public agencies may provide insufficient support or, conversely, compensation practices may establish perverse incentives toward recovery by providing the patient with net income equal to or greater than normally received.
Evaluation of Dose and Safety of AAV7m8 and AAV8BP2 in the Non-Human Primate Retina (2016)

Within the next decade, we will see many gene therapy clinical trials for eye diseases, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recombinant adeno-associated virus (AAV) serotypes have been generated and used successfully in preclinical mouse studies. Because there are numerous anatomic and physiologic differences between the eyes of mice and "men" and because surgical delivery approaches and immunologic responses also differ between these species, this study evaluated the transduction characteristics of two promising new serotypes, AAV7m8 and AAV8BP2, in the retinas of animals that are most similar to those of humans: non-human primates (NHPs). We report that while AAV7m8 efficiently targets a variety of cell types by subretinal injection in NHPs, transduction after intravitreal delivery was mostly restricted to the inner retina at lower doses that did not induce an immune response. AAV8BP2 targets the cone photoreceptors efficiently but bipolar cells inefficiently by subretinal injection. Additionally, transduction by both serotypes in the anterior chamber of the eye and the optic pathway of the brain was observed post-intravitreal delivery. Finally, we assessed immunogenicity, keeping in mind that these AAV capsids may be used in future clinical trials. We found that AAV8BP2 had a better safety profile compared with AAV7m8, even at the highest doses administered. These studies underscore the differences in AAV transduction between mice and primates, highlighting the importance of careful evaluation of therapeutic vectors in NHPs prior to moving to clinical trials.
A proton-antiproton version of the Large Hadron Collider in the LEP tunnel (1987)

Hereditary angioedema (HAE) is a disease caused by defects in the C1 inhibitor gene (SERPING1/C1NH). We screened the entire C1NH gene for mutations in a large series of 87 Spanish families (77 with type I, and 10 with type II HAE) by SSCP, sequencing, Southern blotting, and quantitative multiplex PCR of short fluorescent fragments (QMPSF), and we characterized several defects at the mRNA level. We found large rearrangements in 13 families, and point mutations or microdeletions/insertions in 74 families. The 13 large rearrangements included nine exon deletions, of which at least eight were distinct, two were distinct exon duplications, and two were rearrangements whose precise nature could not be determined. We confirmed that exon 4 is particularly prone to rearrangements. Thirty-six mutations were unreported, and included 10 microdeletions/insertions, 10 missense, five nonsense, eight splicing, and three splicing or missense mutations. Moreover, we detected six novel uncharacterized sequence variants (USV). RT-PCR studies showed that in addition to several intronic splice site mutations tested, the exonic mutations c.882C>G and c.884T>G, located near the 3' end of exon 5, also produced exon skipping. This is the first evidence of SERPING1/C1NH mutations in coding regions that differ from the canonical splice sites that affect splicing, which suggests the presence of an exonic splicing enhancer (ESE) in exon 5.
Self-association of herpes simplex virus type 1 ICP35 is via coiled-coil interactions and promotes stable interaction with the major capsid protein (1997)

The ordered copolymerization of viral proteins to form the herpes simplex virus (HSV) capsid occurs within the nucleus of the infected cell and is a complex process involving the products of at least six viral genes. In common with capsid assembly in double-stranded DNA bacteriophages, HSV capsid assembly proceeds via the assembly of an outer capsid shell around an interior scaffold. This capsid intermediate matures through loss of the scaffold and packaging of the viral genomic DNA. The interior of the HSV capsid intermediate contains the viral protease and assembly protein which compose the scaffold. Proteolytic processing of these proteins is essential for and accompanies capsid maturation. The assembly protein (ICP35) is the primary component of the scaffold, and previous studies have demonstrated it to be capable of intermolecular association with itself and with the major capsid protein, VP5. We have defined structural elements within ICP35 which are responsible for intermolecular self-association and for interaction with VP5. Yeast (Saccharomyces cerevisiae) two-hybrid assays and far-Western studies with purified recombinant ICP35 mapped a core self-association domain between Ser165 and His219. Site-directed mutations in this domain implicate a putative coiled coil in ICP35 self-association. This coiled-coil motif is highly conserved within the assembly proteins of other alpha herpesviruses. In the two-hybrid assay the core self-association domain was sufficient to mediate stable self-association only in the presence of additional structural elements in either N- or C-terminal flanking regions. These regions also contain conserved sequences which exhibit a high propensity for alpha helicity and may contribute to self-association by forming additional short coiled coils. Our data supports a model in which ICP35 molecules have an extended conformation and associate in parallel orientation through homomeric coiled-coil interactions. In additional two-hybrid experiments we evaluated ICP35 mutants for association with VP5. We discovered that in addition to the C-terminal 25 amino acids of ICP35, previously shown to be required for VP5 binding, an additional upstream region was required. This region is between Ser165 and His234 and contains the core self-association domain. Site-directed mutations and construction of chimeric molecules in which the self-association domain of ICP35 was replaced by the GCN4 leucine zipper indicated that this region contributes to VP5 binding through mediating self-association of ICP35 and not through direct binding interactions. Our results suggest that self-association of ICP35 strongly promotes stable association with VP5 in vivo and are consistent with capsid formation proceeding via formation of stable subassemblies of ICP35 and VP5 which subsequently assemble into capsid intermediates in the nucleus.
Backpack carrier Patent (1970)

Backpack carrier with retractable legs suitable for lunar exploration and convertible to rescue vehicle
Structured multiprogramming (1972)

This paper presents a proposal for structured representation of multiprogramming in a high level language. The notation used explicitly associates a data structure shared by concurrent processes with operations defined on it. This clarifies the meaning of programs and permits a large class of time-dependent errors to be caught at compile time. A combination of critical regions and event variables enables the programmer to control scheduling of resources among competing processes to any degree desired. These concepts are sufficiently safe to use not only within operating systems but also within user programs.
A Control Strategy for a Distributed Power Generation Microgrid Application With Voltage- and Current-Controlled Source Converter (2010)

This paper presents a pseudodroop control structure integrated within a microgrid system through distributed power generation (DPG) modules capable to function in off-grid islanded, genset-connected, and grid-connected modes of operation. System efficiency has an important role in order to harvest the maximum available renewable energy from dc or ac sources while providing power backup capability. A control strategy is proposed in off-grid islanded mode method based on the microgrid line-frequency control as agent of communication for energy control between the DPG modules. A critical case is where the ac load demand could be lower than the available power from the photovoltaic solar array, where the battery bank can be overcharged with unrecoverable damage consequences. The DPG voltage-forming module controls the battery charge algorithm with a frequency-generator function, and the DPG current source module controls its output current through a frequency-detection function. The physical installation between DPG modules is independent, since no additional communication wiring is needed between power modules, which represent another integration advantage within the microgrid-type application.
Compact Modeling of Data Using Independent Variable Group Analysis (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this paper, we introduce a modeling approach called independent variable group analysis (IVGA) which can be used for finding an efficient structural representation for a given data set. The basic idea is to determine such a grouping for the variables of the data set that mutually dependent variables are grouped together whereas mutually independent or weakly dependent variables end up in separate groups. Computation of an IVGA model requires a combinatorial algorithm for grouping of the variables and a modeling algorithm for the groups. In order to be able to compare different groupings, a cost function which reflects the quality of a grouping is also required. Such a cost function can be derived, for example, using the variational Bayesian approach, which is employed in our study. This approach is also shown to be approximately equivalent to minimizing the mutual information between the groups. The modeling task is computationally demanding. We describe an efficient heuristic grouping algorithm for the variables and derive a computationally light nonlinear mixture model for modeling of the dependencies within the groups. Finally, we carry out a set of experiments which indicate that IVGA may turn out to be beneficial in many different applications. </para>
Addressing the weight problem (2007)

Obesity has been identified as a major public health problem affecting all age groups. There is accumulating evidence that obesity is associated with serious health problems which include cardiovascular disease, type 2 diabetes and some cancers (WHO, 2000), in addition to reduced quality of life with obesity having a negative impact on psychological and social wellbeing (Blissmer et al, 2006).
Qualitative work overload and other risk factors related to hypertension risk among Indonesian Police Mobile Brigade (Brimob) (2008)

Members of the Police Mobile Brigade (Brimob) can suffer from hypertension which is related to work stressors and other risk factors. This study aimed to identify the relationship between work stressors and other hypertensive risk factors. The subjects of this cross-sectional study were members of the Brimob undergoing their periodic medical check-up during July-October 2007. A subject was hypertensive if systolic blood pressure (SBP) was 140 mmHg or higher, or diastolic (DBD) 90 mmHg, or higher or taking antihypertensive drugs. Normal subjects were those who had SBP less than 120 mmHg and DBP less than 80 mmHg, and have never been diagnosed with hypertension. A number of 336 Brimobs aged 21 to 51 years participated in this study, 111 had high blood pressure and 79 had normal blood pressure. Hypertension was found to be related to excessive body weight and qualitative work overload. Age, work, lifestyle, history of diabetes, hypertension in the family, and other work stressors were not found to increase the risk of hypertension. Medium to high level qualitative work overload had a two-fold risk for hypertension [relative risk adjusted (RRa) = 2.00; 95% confidence interval (CI) = 0.97-4.14; p = 0.060]. Overweight subjects had 48% increased risk to hypertension (RRa = 1.48; 95% CI = 0.98-2.22). Obese subjects had a two-fold risk of being hypertensive (RRa = 2.21; 95%CI = 1.51 - 3.14). Qualitative work overload and obesity increased the risk of hypertension. These risk factors should therefore be controlled. (Med J Indones 2008; 17: 188-96)
Parcellation of human mesial area 6: cytoarchitectonic evidence for three separate areas (1998)

The mesial sector of primate area 6 is usually described as consisting of two distinct areas: the supplementary motor area (SMA or SMA proper) and the pre-SMA. Recent human brain imaging studies showed, however, that this subdivision is not completely satisfactory and that, most likely, SMA proper consists of two functionally distinct parts. In order to elucidate whether this hypothesis has an anatomical counterpart, we examined the cytoarchitectonic organization of human mesial area 6 in three brains of subjects deceased without any previous sign of neurological disorders. The data showed that human mesial area 6 consists of three separate cytoarchitectonic areas. Two of them are located mostly caudal to the vertical line transversing the anterior commissure (VCA line), the third one is located rostral to it. Given the location and some architectonic similarities between the two caudal areas, we named them caudal SMA (SMAc) and rostral SMA (SMAr). The area rostral to the VCA line is referred to as pre-SMA. The possible functional role of the three areas is discussed.
La progression des Francs en Gaule du Nord au Ve siècle. Histoire et archéologie (2011)

D. Geuenich
Remote Sensing Parameterization of Regional Net Radiation over the Heterogeneous Land Surface of GAME-Tibet, HEIFE and AECMP'95 (Session 6: Large Scale Energy and Water Balances studies) (2001)

departmental bulletin paper
Rapid Analytical Method for the Determination of Aflatoxins in Plant-Derived Dietary Supplement and Cosmetic Oils (2010)

Consumption of edible oils derived from conventional crop plants is increasing because they are generally regarded as healthier alternatives to animal-based fats and oils. More recently, there has been increased interest in the use of alternative specialty plant-derived oils, including those from tree nuts (almonds, pistachios, and walnuts) and botanicals (borage, evening primrose, and perilla) both for direct human consumption (e.g., as salad dressings) and for the preparation of cosmetics, soaps, and fragrance oils. This has raised the issue as to whether or not exposure to aflatoxins can result from such oils. Although most crops are subject to analysis and control, it has generally been assumed that plant oils do not retain aflatoxins due to the high polarity and lipophobicity of these compounds. There is virtually no scientific evidence to support this supposition, and available information is conflicting. To improve the safety and consistency of botanicals and dietary supplements, research is needed to establish whether or not oils used directly, or in the formulation of products, contain aflatoxins. A validated analytical method for the analysis of aflatoxins in plant-derived oils is essential to establish the safety of dietary supplements for consumption or cosmetic use that contain such oils. The aim of this research was therefore to develop an HPLC method applicable to a wide variety of oils from different plant sources spiked with aflatoxins, thereby providing a basis for a comprehensive project to establish an intra- and interlaboratory validated analytical method for the analysis of aflatoxins in dietary supplements and cosmetics formulated with plant oils.
Contactless Measurement of Substation Busbars Voltages and Waveforms Reconstruction Using Electric Field Sensors and Artificial Neural Network (2014)

This paper presents a method for contactless measurement of instantaneous voltage and waveform reconstruction for use in a medium voltage (MV) indoor substation. Voltage waveforms are reconstructed by artificial neural network (ANN) using the signals originating from electric field sensors located under MV bus. The method is validated by the experiment in a typical indoor MV substation. Depending on the selection of ANN architecture and data used for training the root mean squared error of waveforms, reconstruction as low as 0.3% to 2.1% can be achieved in a steady state. The practical advice on the application of the proposed measurement method in a production environment is also given.
Cache Portal: Technology for Accelerating Database-driven e-commerce Web Sites (2001)

Response time is one key point of di erentiation among electronic commerce (e-commerce) Web sites. Snafu and slow-downs at major Web sites during special events or peak times demonstrate the diAEculty of scaling up ecommerce sites. Such slow response times and down times can be devastating for e-commerce sites as indicated in a recent study by Zona Research[1] on the relationship between Web page download time and user abandonment rate. The study shows that only 2% of users will leave a Web site (i.e. abandonment rate) if the download time is less than 7 seconds. However, The abandonment rate goes up to 70% when the download time is around 12 seconds. This study clearly establishes the importance of fast response times to an e-commerce Web site to retain its customers.
Re-embedding words (2013)

We present a fast method for re-purposing existing semantic word vectors to improve performance in a supervised task. Recently, with an increase in computing resources, it became possible to learn rich word embeddings from massive amounts of unlabeled data. However, some methods take days or weeks to learn good embeddings, and some are notoriously difficult to train. We propose a method that takes as input an existing embedding, some labeled data, and produces an embedding in the same space, but with a better predictive performance in the supervised task. We show improvement on the task of sentiment classification with respect to several baselines, and observe that the approach is most useful when the training set is sufficiently small.
Immune Complex-induced Integrin Activation and L-plastin Phosphorylation Require Protein Kinase A (1999)

Integrins in resting leukocytes are poorly adhesive, and cell activation is required to induce integrin-mediated adhesion. We recently demonstrated a close correlation between phosphorylation of Ser(5) in L-plastin (LPL), a leukocyte-specific 67-kDa actin bundling protein, and activation of alpha(M)beta(2)-mediated adhesion in polymorphonuclear neutrophils (PMN) (Jones, S. L., Wang, J., Turck, C. W., and Brown, E. J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9331-9336). However, the kinase that phosphorylates LPL Ser(5) has not been identified. We found that cAMP-dependent protein kinase (PKA), but not a variety of other serine kinases, can specifically phosphorylate LPL and LPL-derived peptides on Ser(5) in vitro. The cell-permeable cAMP analog 8-bromo-cAMP and the adenylate cyclase activator forskolin both induce LPL phosphorylation in cells. Two PKA inhibitors, H89 and KT5720, inhibited immune complex (IC)-stimulated LPL phosphorylation as well as IC-induced activation of alpha(M)beta(2)-mediated adhesion in PMN. The dose response of H89 inhibition of PMN adhesion correlated with its inhibition of LPL phosphorylation in response to IC. IC stimulation also transiently increased intracellular cAMP concentration in PMN. Thus, PKA functions in an integrin activation pathway initiated by IC binding to Fcgamma receptors in addition to its better known role as a negative regulator of cell activation by G protein-coupled receptors. In contrast, LPL Ser(5) phosphorylation and PMN adhesion induced by formylmethionyl-leucylphenylalanine or phorbol myristate acetate were not affected by PKA inhibitors, suggesting that a different kinase(s) is responsible for LPL phosphorylation in response to these agonists. Phosphoinositidyl 3-kinase also is required for FcgammaR but not formylmethionyl-leucylphenylalanine- or phorbol myristate acetate-induced LPL phosphorylation and activation of alpha(M)beta(2). Two phosphoinositidyl 3-kinase inhibitors blocked FcgammaR-induced cAMP accumulation, demonstrating that this kinase acts upstream of PKA. These data demonstrate a necessary role for PKA in IC-induced integrin activation and LPL phosphorylation.