gebhart/patrepeval huggingface dataset:
iOS Hacker's Handbook (2012)

Discover all the security risks and exploits that can threaten iOS-based mobile devicesiOS is Apple's mobile operating system for the iPhone and iPad. With the introduction of iOS5, many security issues have come to light. This book explains and discusses them all. The award-winning author team, experts in Mac and iOS security, examines the vulnerabilities and the internals of iOS to show how attacks can be mitigated. The book explains how the operating system works, its overall security architecture, and the security risks associated with it, as well as exploits, rootkits, and other payloads developed for it. Covers iOS security architecture, vulnerability hunting, exploit writing, and how iOS jailbreaks workExplores iOS enterprise and encryption, code signing and memory protection, sandboxing, iPhone fuzzing, exploitation, ROP payloads, and baseband attacksAlso examines kernel debugging and exploitation Companion website includes source code and tools to facilitate your effortsiOS Hacker's Handbook arms you with the tools needed to identify, understand, and foil iOS attacks.
Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogs: potent angiotensin converting enzyme inhibitors (1981)

A new approach was developed for the synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline (1) and 23 analogues. The delta-(acylamino)-gamma-keto acid intermediates were obtained by a modified Dakin--West reaction using 3-carbomethoxypropionyl chloride. Acylation of L-proline and recrystallization of the mixture of diastereomers gave the optically pure title compound in three reaction steps. The in vitro angiotensin converting enzyme (ACE) inhibitory activity of 1 was confirmed. Some of the novel analogues (6, 11, 13, and 17) were also found to be potent inhibitors of ACE in vitro with an IC50 of 1.4-8.8 x 10(-9) M (IC50 for captopril = 0.9 x 10(-8) M). In vivo these compounds (6, 11, 17, and 18) were much less active than captopril, especially by the oral route. Against angiotensin I (AI) challenge in normotensive conscious rats, 1 and 6 produced less than 50% inhibition at 30 mg/kg po but 57 to 82% inhibition at 3 mg/kg iv. Inhibition by both routes lasted less than 1 h. In renal hypertensive rats, 1 and 15 of its analogues failed to produce significant blood pressure lowering effects, in contrast to the marked effects of captopril. Near maximum inhibition of AI was achieved by continuous intravenous infusions of 1 and 20, suggesting that limited oral activity may by due to degradation and/or clearance.
Valproic acid‐induced changes in gene expression during neurulation in a mouse model (1996)

The teratogenic potential of valproic acid has been well established both in experimental models and in human clinical studies. As with all human teratogens, there are genetically determined differences in individual susceptibility to the induction of congenital defects. Using a mouse model of valproate-induced neural tube defects, a study was undertaken to examine differential changes in gene expression for selected transcription factor (Pax-3, Emx-1, Emx-2, c-fos, c-jun, creb) and cell cycle checkpoint genes (bcl-2, p53, wee-1) during neural tube closure. In general, exposure to teratogenic concentrations of valproic acid elicited GD 9:12 control levels of transcription factor mRNA expression in GD 9:0 embryos of both strains. This accelerated developmental profile is marked by significant elevation of Emx-1, Emx-2, c-fos, c-jun, and creb expression. There was also a significant overexpression of the cell cycle genes p53 and bcl-2 in the LM/Bc embryos in response to the teratogenic insult. Examination of the ratio of expression of these genes clearly favored bcl-2, which supports the hypothesis that altered neuroepithelial cell proliferation rates, rather than increased apoptosis, is the underlying mechanism by which valproic acid alters normal neural tube morphogenesis. An investigation into interactive effects of these genes on the molecular profile of GD 9:0 embryos further validated this observation. That is, the overall proliferative state among the control embryos was prematurely modified into a more differentiated state following teratogenic insult. These results suggest that alterations in the expression of multiple genes are most likely responsible for valproic acid-induced neural tube defects. Teratology 54:284–297, 1996. © 1997 Wiley-Liss, Inc.
Internalization of interleukin 2 (IL-2) by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines. (1987)

Abstract During the growth of interleukin 2 (IL-2)-dependent T cells IL-2 binding is followed by internalization of the complex between IL-2 and the high affinity IL-2 receptor (HA-IL-2R). The respective role of IL-2 binding to HA-IL-2R and internalization of the complex has been examined. Monoclonal antibody 7D4 (IgM) blocks IL-2-dependent T cell growth although it does not affect IL-2 binding to HA-IL-2R. We show here that 7D4 inhibits T cell growth by blocking IL-2 internalization by HA-IL-2R. In contrast, Fab fragments prepared from 7D4 neither block IL-2 internalization nor inhibit T cell growth. Monoclonal 5A2, that recognizes an epitope related to the IL-2 binding site as well as its Fab fragment, inhibits T cell growth and IL-2 internalization. Monoclonal antibody 7D4, because of its pentameric structure, probably aggregates the IL-2R at the T cell surface and therefore prevents it internalization. The data presented in this paper suggest that simple occupancy of HA-IL-2R by IL-2 is not sufficient to transduce the T cell growth signal; this signal is transmitted only after internalization of the IL-2/HA-IL-2R complex.
Expression of<scp>CD</scp>163, interleukin‐10, and interferon‐gamma in oral squamous cell carcinoma: mutual relationships and prognostic implications (2014)

Tumor-associated macrophages (TAMs) and their associated inflammatory cytokines represent the major inflammatory component of the stroma of many tumors and can affect prognosis in the case of neoplasms. The objective of this study was to determine the prognostic significance of CD163(+) cells, interleukin-10 (IL-10), and interferon-gamma (IFN-γ) in oral lesions associated with oral squamous cell carcinoma (OSCC). The levels of CD163, IFN-γ, and IL-10 in the tissue samples of 240 patients with OSCC and 58 patients with other oral lesions were assessed by immunohistochemistry. Individuals with low IFN-γ levels, high IL-10 levels, and low CD163 levels were of special concern with respect to OSCC progression. We found that high levels of CD163, or a combination of low IFN-γ levels, high IL-10 levels, and low CD163 levels, were associated with poorer overall survival (OS). CD163(+) cells provide better predictive power for OS in comparison with traditional markers, such as clinical stage and lymph node metastasis. Therefore, CD163(+) cells may be effective prognostic predictors of OSCC. IL-10 may also indicate poor outcomes when IFN-γ secretion is low and the cells are CD163(-) .
GMM-based speaker age and gender classification in Czech and Slovak (2017)

Abstract The paper describes an experiment with using the Gaussian mixture models (GMM) for automatic classification of the speaker age and gender. It analyses and compares the influence of different number of mixtures and different types of speech features used for GMM gender/age classification. Dependence of the computational complexity on the number of used mixtures is also analysed. Finally, the GMM classification accuracy is compared with the output of the conventional listening tests. The results of these objective and subjective evaluations are in correspondence.
A Specialized Citric Acid Cycle Requiring Succinyl-Coenzyme A (CoA):Acetate CoA-Transferase (AarC) Confers Acetic Acid Resistance on the Acidophile <i>Acetobacter aceti</i> (2008)

Microbes tailor macromolecules and metabolism to overcome specific environmental challenges. Acetic acid bacteria perform the aerobic oxidation of ethanol to acetic acid and are generally resistant to high levels of these two membrane-permeable poisons. The citric acid cycle (CAC) is linked to acetic acid resistance in Acetobacter aceti by several observations, among them the oxidation of acetate to CO2 by highly resistant acetic acid bacteria and the previously unexplained role of A. aceti citrate synthase (AarA) in acetic acid resistance at a low pH. Here we assign specific biochemical roles to the other components of the A. aceti strain 1023 aarABC region. AarC is succinyl-coenzyme A (CoA):acetate CoA-transferase, which replaces succinyl-CoA synthetase in a variant CAC. This new bypass appears to reduce metabolic demand for free CoA, reliance upon nucleotide pools, and the likely effect of variable cytoplasmic pH upon CAC flux. The putative aarB gene is reassigned to SixA, a known activator of CAC flux. Carbon overflow pathways are triggered in many bacteria during metabolic limitation, which typically leads to the production and diffusive loss of acetate. Since acetate overflow is not feasible for A. aceti, a CO(2) loss strategy that allows acetic acid removal without substrate-level (de)phosphorylation may instead be employed. All three aar genes, therefore, support flux through a complete but unorthodox CAC that is needed to lower cytoplasmic acetate levels.
ATM for military communications (2002)

The objective of using asynchronous transfer mode (ATM) as the basic transfer mode in the new generation of NATO tactical communication systems is the creation of a unified network architecture able to support both bursty (e.g. data) and synchronous (e.g. voice) services in a flexible and organic way. Although military operational conditions may be significantly different from those of commercial networks, the future military ATM systems should benefit maximally from the massive R&D effort spent on commercial ATM systems. The paper evaluates the basic operating requirements for an ATM network against those typical for conventional military tactical communication networks. The throughput and delay performance for respectively data services and low bit-rate voice services are assessed for a network of worst case size incorporating low bit-rate, high error rate trunks. A number of techniques are suggested to enhance the network performance for these services. Addition of forward error correction (FEC), possibly in combination with cell header compression at the link level, is recommended to enhance radio link performance. Prioritisation of connections is recommended for delay sensitive services. It is shown that with a combined use of these techniques ATM can be used in the tactical environment as a unifying technology to meet all of the future service requirements. Further a recommendation is made for the development of tactical quality of service (QOS) requirements.
The making of fetal surgery (2010)

Fetal diagnosis prompts the question for fetal therapy in highly selected cases. Some conditions are suitable for in utero surgical intervention. This paper reviews historically important steps in the development of fetal surgery. The first invasive fetal intervention in 1963 was an intra-uterine blood transfusion. It took another 20 years to understand the pathophysiology of other candidate fetal conditions and to develop safe anaesthetic and surgical techniques before the team at the University of California at San Francisco performed its first urinary diversion through hysterotomy. This procedure would be abandoned as renal and pulmonary function could be just as effectively salvaged by ultrasound-guided insertion of a bladder shunt. Fetoscopy is another method for direct access to the feto-placental unit. It was historically used for fetal visualisation to guide biopsies or for vascular access but was also abandoned following the introduction of high-resolution ultrasound. Miniaturisation revived fetoscopy in the 1990 s, since when it has been successfully used to operate on the placenta and umbilical cord. Today, it is also used in fetuses with congenital diaphragmatic hernia (CDH), in whom lung growth is triggered by percutaneous tracheal occlusion. It can also be used to diagnose and treat urinary obstruction. Many fetal interventions remain investigational but for a number of conditions randomised trials have established the role of in utero surgery, making fetal surgery a clinical reality in a number of fetal therapy programmes. The safety of fetal surgery is such that even non-lethal conditions, such as myelomeningocoele repair, are at this moment considered a potential indication. This, as well as fetal intervention for CDH, is currently being investigated in randomised trials.
A Broadband Quasi-Optical Terahertz Detector Utilizing a Zero Bias Schottky Diode (2010)

A quasi-optical broadband terahertz detector using a zero bias Schottky diode mounted on a self-complimentary sinuous antenna has been developed. Design and characterization of this detector are described. Measurements show that a responsivity of 300-1000 V/W covering the frequency range of 150-440 GHz has been achieved. The detector performance has been compared to waveguide detectors covering four frequency bands up to 600 GHz. A recent measurement at 600-900 GHz yielded the same output voltage as a waveguide detector. The noise equivalent power level of this detector is estimated to be 5-20 pW/√(Hz) based on the measurements of similar detectors.
Optical self-switching of unidirectional distributively coupled waves (1995)

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Oxidative stress and apoptosis (2000)

Apoptosis or programmed cell death, is essential for the normal functioning and survival of most multi-cellular organisms. The morphological and biochemical characteristics of apoptosis, however, are highly conserved during the evolution. It is currently believed that apoptosis can be divided into at least three functionally distinct phases, i.e. induction, effector and execution phase. Recent studies have demonstrated that reactive oxygen species (ROS) and the resulting oxidative stress play a pivotal role in apoptosis. Antioxidants and thiol reductants, such as N-acetylcysteine, and overexpression of manganese superoxide (MnSOD) can block or delay apoptosis. Bcl-2, an endogenously produced protein, has been shown to prevent cells from dying of apoptosis apparently by an antioxidative mechanism. Taken together ROS, and the resulting cellular redox change, can be part of signal transduction pathway during apoptosis. It is now established that mitochondria play a prominent role in apoptosis. During mitochondrial dysfunction, several essential players of apoptosis, including pro-caspases, cytochrome C, apoptosis-inducing factor (AIF), and apoptotic protease-activating factor-1 (APAF-1) are released into the cytosol. The multimeric complex formation of cytochrome C, APAF-1 and caspase 9 activates downstream caspases leading to apoptotic cell death. All the three functional phases of apoptosis are under the influence of regulatory controls. Thus, increasing evidences provide support that oxidative stress and apoptosis are closely linked physiological phenomena and are implicated in pathophysiology of some of the chronic diseases including AIDS, autoimmunity, cancer, diabetes mellitus, Alzheimer's and Parkinson's and ischemia of heart and brain.
Dual Mechanisms of Pestiviral Superinfection Exclusion at Entry and RNA Replication (2005)

For many viruses, primary infection has been shown to prevent superinfection by a homologous second virus. In this study, we investigated superinfection exclusion of bovine viral diarrhea virus (BVDV), a positive-sense RNA pestivirus. Cells acutely infected with BVDV were protected from superinfection by homologous BVDV but not with heterologous vesicular stomatitis virus. Superinfection exclusion was established within 30 to 60 min but was lost upon passaging of persistently infected cells. Superinfecting BVDV failed to deliver a translatable genome into acutely infected cells, indicating a block in viral entry. Deletion of structural protein E2 from primary infecting BVDV abolished this exclusion. Bypassing the entry block by RNA transfection revealed a second block at the level of replication but not translation. This exclusion did not require structural protein expression and was inversely correlated with the level of primary BVDV RNA replication. These findings suggest dual mechanisms of pestivirus superinfection exclusion, one at the level of viral entry that requires viral glycoprotein E2 and a second at the level of viral RNA replication.
Marriage Money: The Social Shaping of Money in Marriage and Banking (1999)

FiguresTablesAcknowledgmentsIntroduction1 The study of money as a social and cultural phenomenon2 Studying marriage money3 The boundaries of marriage money4 The meanings of marriage money5 Managing and controlling money in marriage6 Banking separates multiple monies7 Banking money8 The gender of money9 ConclusionAppendixesNotesBibliographyIndex
ChemInform Abstract: Prediction of Aqueous Solubility of Heteroatom‐Containing Organic Compounds from Molecular Structure. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An energy saving based on task migration for mobile edge computing (2019)

Mobile edge computing (MEC), as the key technology to improve user experience in a 5G network, can effectively reduce network transmission delay. Task migration can migrate complex tasks to remote edge servers through wireless networks, solving the problems of insufficient computing capacity and limited battery capacity of mobile terminals. Therefore, in order to solve the problem of “how to realize low-energy migration of complex dependent applications,” a subtask partitioning model with minimum energy consumption is constructed based on the relationship between the subtasks. Aiming at the problem of execution time constraints, the genetic algorithm is used to find the optimal solution, and the migration decision results of each subtask are obtained. In addition, an improved algorithm based on a genetic algorithm is proposed to dynamically adjust the optimal solution obtained by genetic algorithm by determining the proportion of task energy consumption and mobile phone residual power. According to the experimental results, it can be concluded that the fine-grained task migration strategy combines the advantages of mobile edge computing, not only satisfies the smooth execution of tasks, but also reduces the energy consumption of terminal mobile devices. In addition, experiments show that the improved algorithm is more in line with users’ expectations. When the residual power of mobile devices is reduced to a certain value, tasks are migrated to MEC server to prolong standby time.
A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane (1996)

Caveolin is a 22-kDa membrane protein found associated with a coat material decorating the inner membrane surface of caveolae. A remarkable feature of this protein is its ability to migrate from caveolae directly to the endoplasmic reticulum (ER) when membrane cholesterol is oxidized. We now present evidence caveolin is involved in transporting newly synthesized cholesterol from the ER directly to caveolae. MA104 cells and normal human fibroblasts transported new cholesterol to caveolae with a half-time of approximately 10 min. The cholesterol then rapidly flowed from caveolae to non-caveolae membrane. Cholesterol moved out of caveolae even when the supply of fresh cholesterol from the ER was interrupted. Treatment of cells with 10 microg/ml progesterone blocked cholesterol movement from ER to caveolae. Simultaneously, caveolin accumulated in the lumen of the ER, suggesting cholesterol transport is linked to caveolin movement. Caveolae fractions from cells expressing caveolin were enriched in cholesterol 3-4-fold, while the same fractions from cells lacking caveolin were not enriched. Cholesterol transport to the cell surface was nearly 4 times more rapid in cells expressing caveolin than in matched cells lacking caveolin.
Nematicidal Activity of the Volatilome of <i>Eruca sativa</i> on <i>Meloidogyne incognita</i> (2015)

Research on new pesticides based on plant extracts, aimed at the development of nontoxic formulates, has recently gained increased interest. This study investigated the use of the volatilome of rucola (Eruca sativa) as a powerful natural nematicidal agent against the root-knot nematode, Meloidogyne incognita. Analysis of the composition of the volatilome, using GC-MS-SPME, showed that the compound (Z)-3-hexenyl acetate was the most abundant, followed by (Z)-3-hexen-1-ol and erucin, with relative percentages of 22.7 ± 1.6, 15.9 ± 2.3, and 8.6 ± 1.3, respectively. Testing of the nematicidal activity of rucola volatile compounds revealed that erucin, pentyl isothiocyanate, hexyl isothiocyanate, (E)-2-hexenal, 2-ethylfuran, and methyl thiocyanate were the most active with EC50 values of 3.2 ± 1.7, 11.1 ± 5.0, 11.3 ± 2.6, 15.0 ± 3.3, 16.0 ± 5.0, and 18.1 ± 0.6 mg/L, respectively, after 24 h of incubation. Moreover, the nematicidal activity of fresh rucola used as soil amendant in a containerized culture of tomato decreased the nematode infection in a dose-response manner (EC50 = 20.03 mg/g) and plant growth was improved. On the basis of these results, E. sativa can be considered as a promising companion plant in intercropping strategies for tomato growers to control root-knot nematodes.
The International Labour Code 1951 (1953)

The International Labour Code 1951 Get access The International Labour Code 1951. Geneva: International Labour Office, 1952. Vol. I, II. Pp. clv, 1181; xxxix, 1220. William G. Rice William G. Rice *Professor of Law, University of Wisconsin Search for other works by this author on: Oxford Academic Google Scholar The American Journal of Comparative Law, Volume 2, Issue 3, Summer 1953, Pages 404–406, https://doi.org/10.2307/837490 Published: 01 July 1953
Bimodal Method of Determining Fat and Salt Content in Beef Products by Microwave Techniques (2009)

A bimodal microwave technique is presented as a rapid analytical method of estimating the fat and salt content of beef products. The dielectric properties of lean meat, fat, salt, and other nonmeat ingredients (dry and aqueous solutions) and meat blends of typical ingredients used in meat product manufacture are all separately investigated. A broadband coaxial probe technique is used to select frequencies of maximum sensitivity. The optimum frequency for fat determination lies between 8 and 20 GHz, and the optimum frequency for salt determination lies below 4 GHz. For example, by using a WR-90 cell, either the real or imaginary part of the complex permittivity can effectively resolve fat content, whereas the imaginary part of the permittivity correlates well with salt content when using a WR-284 cell. The technique is sufficiently robust to ensure that the dielectric effects of other nonmeat ingredients, temperature, and density do not adversely affect this measurement approach.