gebhart/patrepeval huggingface dataset:
Effect of Qindan Capsule on arterial adventitial fibroblasts (2010)

Objective To investigate the effect and mechanism of the Qindan Capsule-containing serum on adventitial fibroblasts(AFs). Methods AFs were cultured by tissue explant in vitro and induced by TGF-β1. The proliferation of AFs affected by the Qindan Capsule-containing serum with high[750 mg /(kg·d)]or low[150 mg /(kg·d)]dose was detected by MTT. Protein and mRNA expressions of α-SM actin and Smad3 were observed by Western-blot and Real-time PCR respectively. Results Both high and low doses of the Qindan Capsule-containing serum could reduce proliferation of AFs induced by TGF-β1(P 0. 05) and inhibit expressions of mRNA and protein of α-SM actin and Smad3(P 0. 05). Conclusion The Qindan Capsule-containing serum has significant improved and reverse effect on aortic vascular remodeling. The mechanism may be related to inhibiting proliferation and differentiation of AFs through the TGF-β1 /Smad signaling pathway.
Performance monitoring in a Myrinet-connected SHRIMP cluster (1998)

Article Free Access Share on Performance monitoring in a Myrinet-connected SHRIMP cluster Authors: Cheng Liao Depts. of Computer Science and Electrical Engineering, Princeton University, Princeton, NJ Depts. of Computer Science and Electrical Engineering, Princeton University, Princeton, NJView Profile , Margaret Martonosi Depts. of Computer Science and Electrical Engineering, Princeton University, Princeton, NJ Depts. of Computer Science and Electrical Engineering, Princeton University, Princeton, NJView Profile , Douglas W. Clark Depts. of Computer Science and Electrical Engineering, Princeton University, Princeton, NJ Depts. of Computer Science and Electrical Engineering, Princeton University, Princeton, NJView Profile Authors Info & Claims SPDT '98: Proceedings of the SIGMETRICS symposium on Parallel and distributed toolsAugust 1998 Pages 21–29https://doi.org/10.1145/281035.281038Online:01 August 1998Publication History 19citation223DownloadsMetricsTotal Citations19Total Downloads223Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Exploiting Bacterial Glycosylation Machineries for the Synthesis of a Lewis Antigen-containing Glycoprotein (2011)

Glycoproteins constitute a class of compounds of increasing importance for pharmaceutical applications. The manipulation of bacterial protein glycosylation systems from Gram-negative bacteria for the synthesis of recombinant glycoproteins is a promising alternative to the current production methods. Proteins carrying Lewis antigens have been shown to have potential applications for the treatment of diverse autoimmune diseases. In this work, we developed a mixed approach consisting of in vivo and in vitro steps for the synthesis of glycoproteins containing the Lewis x antigen. Using glycosyltransferases from Haemophilus influenzae, we engineered Escherichia coli to assemble a tetrasaccharide on the lipid carrier undecaprenylphosphate. This glycan was transferred in vivo from the lipid to a carrier protein by the Campylobacter jejuni oligosaccharyltransferase PglB. The glycoprotein was then fucosylated in vitro by a truncated fucosyltransferase from Helicobacter pylori. Diverse mass spectrometry techniques were used to confirm the structure of the glycan. The strategy presented here could be adapted in the future for the synthesis of diverse glycoproteins. Our experiments demonstrate that bacterial enzymes can be exploited for the production of glycoproteins carrying glycans present in human cells for potential therapeutic applications.
A Comparison of Ropivacaine 0.5% and Bupivacaine 0.5% for Brachial Plexus Block (1991)

This study compared the effectiveness of 0.5% ropivacaine and 0.5% bupivacaine for brachial plexus block. Forty-eight patients received a subclavian perivascular brachial plexus block for upper-extremity surgery. One group (n = 24) received ropivacaine 0.5% (175 mg) and a second group (n = 24) received bupivacaine 0.5% (175 mg), both without epinephrine. Onset times for analgesia and anesthesia in each of the C5 through T1 brachial plexus dermatomes did not differ significantly between groups. Duration of analgesia and anesthesia was long (mean duration of analgesia, 13-14 h; mean duration of anesthesia, 9-11 h) and also did not differ significantly between groups. Motor block was profound, with shoulder paralysis as well as hand paresis developing in all of the patients in both groups. Two patients in each group required supplemental blocks before surgery. Ropivacaine 0.5% and bupivacaine 0.5% appeared equally effective in providing brachial plexus anesthesia.
Plasma Pro‐C3 (N‐terminal type <scp>III</scp> collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C (2014)

Pro-C3 is a useful test to predict fibrogenesis and monitor disease progression. Moreover, it could differentiate mild from moderate disease. Pro-C3 may become a promising blood parameter be included in future studies for monitoring disease progression and eventually for evaluation of potential antifibrotic therapies.
Theoretical π‐π* absorption, circular dichroic, and linear dichroic spectra of collagen triple helices (1984)

Abstract Absorption, CD, and LD spectra of the π‐π* transition near 200 nm are calculated for poly(Gly‐X‐Y) (X,Y = Gly, Ala, Pro) in four conformations proposed for collagen like triple helices in the recent literature. A dipole interaction model is used with the same optical paramenters as in previous studies of polypeptide spectra. The CD spectra are sensitive to backbone structure and amino acid composition, although the experimentally observed negative peak near 200 nm is a general feature of most the calculated spectra. Interchain interactions significantly affect the CD spectra in most cases. Calculations for (Gly‐Pro‐Ala) 3 and (Gly‐Ala‐Pro) 3 in the triple helical structure of Fraser, MacRae, and Suzuki [(1979) J. Mol. Biol. 129 , 463–481] show absorption, CD, and LD spectra in fairly good agreement with experiment. The characteristics of the π‐π* normal modes responsible for the calculated spectra are compared with those of the component bands resolved from the experimental spectra of collagen by Mandel and Holzwarth [(1973) Biopolymers 12 , 655–674].
Full-color illumination that needs no electric power (2007)

Red, green, and blue phosphorescent resins were developed to realize full-color illuminators that shine without the need for electric power. Red phosphorescence, which used to be weak with conventional red phosphors, was enhanced notably with dye-doped resins in which green or blue phosphors were dispersed uniformly; i.e., brightness increased by seven times and afterglow duration extended by two times. Full-color phosphorescence from violet to red was attained by selecting suitable mixing ratios of the phosphors and dyes.
295. Interaction of boron trichloride with catechol, quinol, resorcinol, and pyrogallol (1959)

W. Gerrard, M. F. Lappert and B. A. Mountfield, J. Chem. Soc., 1959, 1529 DOI: 10.1039/JR9590001529
Controlled oxidation of tantalum and aluminium in a radio-frequency-excited glow discharge (1967)

A controlled method of oxidizing thin films of tantalum and aluminium in a radio-frequency-excited glow discharge is described. The oxide films have been assessed as the dielectric in metal-metal-oxide-metal capacitor structures. Reciprocal capacitance varies linearly with the voltage applied to the metal film in the discharge over the range 0 to 48 v. The process is similar to but less efficient than anodization in a liquid electrolyte. Compared with oxide films formed by liquid anodization the electrical properties are poor, probably because of the more energetic conditions in the discharge.
BIGH3 is overexpressed in clear cell renal cell carcinoma (2008)

To identify new target marker genes in renal cell carcinoma (RCC), we compared the gene expression profiles of clear cell RCC (cc-RCC) and normal kidney tissue using serial analysis of gene expression. Our results revealed that the transforming growth factor beta induced 68 kDa protein (TGF-betaI: beta ig-h3 (BIGH3), plasminogen activator inhibitor-1 (PAI-1) and transforming growth factor beta1 (TGF-beta1) genes are up-regulated in cc-RCC. To further assess the role of BIGH3 in RCC, we investigated the mRNA expression levels of BIGH3, TGFbeta1, PAI-1 and also of TGF-beta1 related genes in 53 RCC and 30 normal kidney tissues by quantitative real-time RT-PCR (QRT-PCR). We further determined the BIGH3 protein levels in 52 cc-RCC paraffin-embedded tissue samples by immunohistochemistry. BIGH3 mRNA was found to be highly overexpressed in cc-RCC compared with normal tissues with an average ratio of 27. The mRNA levels of TGF-beta1 and PAI-1 were also detected at significantly elevated levels in these cancers. Immunohistochemical analysis of BIGH3 also revealed strong staining in the majority of the cc-RCC samples. In addition, the up-regulation of BIGH3 and PAI-1 was found to correlate with the clinicopathological parameters associated with a poorer patient outcome, whereas TGF-beta1 expression was determined to be unrelated to cancer progression. Strong BIGH3 staining thus tended to be associated with a poor prognosis. BIGH3 was also induced in some RCC cell lines by TGF-beta1 stimulation and this correlated well with PAI-1 up-regulation, suggesting that these enhancements are regulated by a similar mechanism in these tumors.
Detection of nuclear quadrupole resonance via induced longitudinal magnetization (1976)

The first measurement of pure nuclear quadrupole splitting energies by monitoring the induced longitudinal magnetic moment has been carried out on a crystal of sapphire at 4.2 °K. Adiabatic fast passage was used to invert the populations of levels split by the quadrupole interaction. A small magnetic field removed the degeneracy of the nuclear states, allowing measurement of the linewidth and spin-lattice relaxation time. Unlike conventional techniques of adiabatic passage, this method, utilizing a SQUID magnetometer, allows determination of the widths of nuclear quadrupole lines without a sacrifice in signal level.
Quantum key distribution model using quantum gates (2012)

In this work, a quantum computing based secret key distribution system is proposed. Quantum gates based encryption and decryption circuits are designed and can be used along with conventional encryption schemes such as the Data Encryption Standards (DES), XoR Cipher and Substitution Cipher etc., in the presentation layer. The quantum communication model is implemented and analyzed for both ideal and noisy channel. Using this model if the channel is eaves dropped, the sender and receiver will detect the eavesdropping attempt, the key will be discarded and another key is retransmitted.
Nearly non-roll-off high efficiency fluorescent yellow organic light-emitting diodes (2011)

This paper demonstrates the employment of a multi-emissive-layer device architecture with smooth cascading energy levels to improve markedly the efficiency, roll-off, and color-stability of a fluorescent yellow organic light-emitting diode. As a tri-emissive layer structure was used in lieu of neat film, for example, the resultant external quantum efficiency was increased from 2.2 and 1.8% to 8.2 and 8.6% between 100 and 1000 cd m−2, while current efficiency increased from 5.8 and 4.6 cd A−1 to 26.5 and 27.2 cd A−1 and efficacy from 4 and 2.4 lm W−1 to 20.6 and 18.3 lm W−1. Moreover, the color stability of the tri-emissive layer structure has become of even higher quality than the neat film counterpart has. The reason why the multi-emissive-layer device exhibits both high efficacy and high color-stability may be attributed to the stepwise energy levels that enable a significant reduction in injection barriers, a wider recombination zone, and a more effective carrier confinement. Additionally, the paired host and guest energy-levels in two of the emissive layers allow excitons to generate on the host to facilitate the occurrence of host-to-guest energy transfer and, thus, high device efficiency. The little roll-off may be due to the different paired host and guest energy-levels in the third emissive layer allowing excitons to generate predominantly on the guest at low voltage, but with increasing excitons generating on the host as the voltage increases, fully utilizing all the possible recombination sites.
An Attenuated aroA Salmonella typhimurium Vaccine Elicits Humoral and Cellular Immunity to Cloned  -Galactosidase in Mice (1987)

beta-Galactosidase (GZ) is an intracellular protein that is frequently used to express cloned antigens as fusion proteins in Escherichia coli. Salmonella typhimurium strain SL3261, an attenuated aroA vaccine strain, was used as a carrier for the plasmid pXY411, which directs the expression of GZ in salmonellae (which do not normally produce this protein). The resulting strain--SL3261(pXY411)--expressed GZ as an intracellular antigen. The plasmid was stable in vitro and in vivo and did not significantly alter the behavior of strain SL3261 in mice. Animals intravenously vaccinated with this construct developed circulating antibodies to GZ, as measured by ELISA, and delayed hypersensitivity to the antigen injected in the footpad. These results indicate that attenuated salmonellae may be expected to elicit both humoral and cellular responses to intracellular cloned antigens.
Hydrogen-Bonded Supramolecular Architectures of Organic Salts Based on Aromatic Tetracarboxylic Acids and Amines (2006)

Crystallizations of two aromatic tetracarboxylic acids, 1,4,5,8-naphthalenetetracarboxylic acid (H4NTA) and 3,4,9,10-perylenetetracarboxylic acid (H4PTA), with amines (triethylamine, TEA; ethylenediamine, EDA) in H2O give four H-bonded organic salts, [HTEA]2·[H2NTA]·2H2O (1), [HTEA]2·[H2PTA] (2), [H2EDA]2·[NTA]·3H2O (3), and [H2EDA]2·[PTA]·8H2O (4), which were structurally characterized by X-ray diffraction. In the TEA salts (1 and 2), two protons of each acid are transferred and the supramolecular H-bonded entities are generated by only acid anions (or together with H2O), whereas in 3 and 4 all four protons are transferred and both H2EDA2+ and acid anions contribute to the final framework formation, probably due to the differences in basicities of the two amines. Salt 1 has a layer structure stabilized by O−H···O H-bonds between H2O and H2NTA2- and contains a normal graph set of R24(8) (formed by two H2O and two carboxyl O atoms). Different from 1, 2 contains a 1-D structure with an R22(16) ring formed by O−H···O H-bonds between H2PTA2-. Both 3 and 4 have 3-D framework structures with well-defined 1-D channels, assembled by complicated N−H···O and O−H···O H-bonds. All the O and amino H atoms in H2EDA2+ and NTA4- or PTA4- participate in the H-bonding linkages; however both salts have great structural differences with different numbers of cocrystallized H2O. It is interesting that the 1-D channels in 3 are circular and occupied by single H2O line but those in 4 are rectangular and filled by H2O tapes with a T4(2)6(2) pattern. Herein, TEA with a larger volume and simple H-bonding manner is considered as a terminal H-bonding moiety to form low-dimensional networks, whereas EDA with favorable flexibility and various H-bonding modes is adopted to link the acid components to give higher dimensional frameworks. In addition, H4PTA seems to be proven as an interesting H-bonding molecular tecton with great potential in crystal engineering, especially for preparing materials with large cavities/channels. The stability and luminescent property of 4 have also been studied preliminarily.
<i>Borrelia burgdorferi</i>Complement Regulator-Acquiring Surface Protein 2 (CspZ) as a Serological Marker of Human Lyme Disease (2007)

Serological diagnosis of Lyme disease may be complicated by antigenic differences between infecting organisms and those used as test references. Accordingly, it would be helpful to include antigens whose sequences are well conserved by a broad range of Lyme disease spirochetes. In the present study, line blot analyses were performed using recombinant complement regulator-acquiring surface protein 2 (BbCRASP-2) from Borrelia burgdorferi sensu stricto strain B31 and serum samples from human Lyme disease patients from throughout the United States and Germany. The results indicated that a large proportion of the patients had produced antibodies recognizing recombinant BbCRASP-2. In addition, Lyme disease spirochetes isolated from across North America and Europe were found to contain genes encoding proteins with high degrees of similarity to the B. burgdorferi type strain B31 BbCRASP-2, consistent with the high percentage of serologically positive patients. These data indicate that BbCRASP-2 may be valuable for use in a widely effective serological assay.
Iron-Catalyzed Suzuki−Miyaura Coupling of Alkyl Halides (2010)

In the presence of novel iron(II) chloride-diphosphine complexes and magnesium bromide, lithium arylborates react with primary and secondary alkyl halides to give the corresponding coupling products in good to excellent yields. High functional group compatibility is also demonstrated in the reactions of substrates possessing reactive substituents, such as alkoxycarbonyl, cyano, and carbonyl groups.
Embedded hybrid LDO topologies for digital load circuits (2016)

Digital low dropout voltage regulators provide digital process synthesizability, fast transient response and performance adaptation but lack steady state voltage regulation performance. To overcome this lack of steady state accuracy due to limit cycle oscillations, a hybrid low dropout voltage regulator topology designed in 130 nm CMOS process is presented. In the proposed topology, the operational discrete dynamics of a digital regulator are augmented with continuous dynamics of an analog regulator in a parallel controller configuration to achieve better steady state performance. It has been shown that a higher gain bandwidth product of the analog LDO achieves greater reduction of limit cycle oscillations but uneven controller strengths and power consumption limits its use for wide operational range of digital load circuits.
Effect of Delays on TCP Performance (2005)

This paper has several contributions. First, we report that long sudden delays during data transfers are not uncommon in the GPRS wireless WAN. Long sudden delays can lead to spurious TCP timeouts and unnecessary retransmissions. Second, we show that the New Reno algorithm increases the penalty of spurious TCP timeouts and that an aggressive TCP retransmission timer may trigger a chain of spurious retransmissions. Third, we test how four widely deployed TCP implementations recover from a spurious timeout and notice that two of them have severe problems to recover. Finally, we discuss several existing ways to alleviate the problems.
Dielectric ring based metamaterial perfect reflector (2019)

In this work a novel design of an all-dielectric metamaterial perfect reflector has been proposed which exhibits 100% reflectance at a particular frequency and high reflectance in a broad range of wavelengths. This design is purely dielectric, hence, is free from resistive losses which are intrinsic to metallic thin film type reflectors. The design is compatible to on-chip fabrication techniques and can be realised by using well known methods such as optical lithography or electron beam lithography. The proposed structure can augment the performance of low loss cavity resonators, frequency selective filters, sensing, directive emission of radiation, etc.
The impact of If-conversion and branch prediction on program execution on the Intel/sup R/ Itanium/sup TM/ processor (2001)

The research community has studied if-conversion for many years. However, due to the lack of existing hardware, studies were conducted by simulating code generated by experimental compilers. This paper presents the first comprehensive study of the use of predication to implement if-conversion on production hardware with a near-production compiler. To better understand trends in the measurements, we generated binaries at three increasing levels of if-conversion aggressiveness. For each level, we gathered data regarding the global runtime effects of if-conversion on overall execution time, register pressure, code size, and branch behavior. Furthermore, we studied the inherent characteristics of program control-flow structure related to branching to help determine fundamental limits of if-conversion. Our results show that on the Itanium™ processor if-conversion could potentially remove 29% of the branch mispredictions in SPEC2OOOCINT but that this accounts for a substantially smaller overall program speedup than previously reported.
Hand shape estimation using sequence of multiple viewpoint images based on transition network (2004)

Abstract In this paper, the authors use gesture images obtained from multiple cameras to estimate hand shapes. First, for the entered multiple viewpoint images, they use the outline in each separate image to extract features, create feature vectors, and calculate the difference between the image and each model image in the database. Next, they calculate the shape complexity as a value indicating the degree to which the image of each viewpoint is distinctive and use these values to integrate the individual differences to obtain the overall difference. They select the model image having the minimum integrated difference and let it be the estimation result. The authors also use a transition network to reduce the amount of searching during hand shape estimation. During the training stage, the authors used training image sequences to automatically register model images and possible transitions between model images to create a transition network. During the estimation stage, they used the transition network to perform matching more efficiently by limiting the candidates to only model images that can transition from the corresponding model image in the preceding frame. The authors performed experiments using binocular images to estimate hand shapes and showed the results of matching using the transition network. © 2004 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 87(8): 33–42, 2004; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecjc.20089
Comparison of lidless &#x00026; overmold flip chip package with 40nm ultra low-k Silicon Technology (2010)

Current portable electronic products are driving component packaging towards Flip Chip Packaging Technologies for integrating multiple electrical functionalities. The driver for flip chip continues to be performance and small form factor. This paper evaluates the lidless and molded flip chip packages with 40nm ultra low K (ULK) Silicon Technology. A comparative study on the two package types is carried out showing the effect of substrate core thickness and die thickness on the package coplanarity. Second level solder fatigue life between the two packages are also discussed. Finite Element Method (FEM) is done using various packaging design parameters and material properties for two packages types to study their effect on the key output parameters like stress in ULK Silicon, component and board level reliability.