gebhart/patrepeval huggingface dataset:
Differentially Painting Human Chromosome Arms with Combined Binary Ratio-labeling Fluorescence In Situ Hybridization (2000)

Recently we developed a novel strategy for differentially painting all 24 human chromosomes. It is termed COBRA-FISH, short for combined binary ratio labeling-fluorescence in situ hybridization. COBRA-FISH is distinct from the pure combinatorial approach in that only 4 instead of 5 fluorophores are needed to achieve color discrimination of 24 targets. Furthermore, multiplicity can be increased to 48 by introduction of a fifth fluorophore. Here we show that color identification by COBRA-FISH of all of the p and q arms of human chromosomes is feasible, and we apply the technique for detecting and elucidating intra- and interchromosomal rearrangements. Compared with 24-color whole chromosome painting FISH, PQ-COBRA-FISH considerably enhances the ability to determine the composition of rearranged chromosomes as demonstrated by the identification of pericentric inversions and isochromosomes as well as the elucidation of the arm identity of chromosomal material involved in complex translocations that occur in solid tumors.
High Rate X-Ray Fluorescence Analysis by Pulsed Excitation (1972)

We describe the application of pulsed X-ray excitation to X-ray fluorescence spectrometry as a method for increasing the output counting rate of the system by a substantial factor. Using a pulsed X-ray tube that is immediately turned off when a signal is detected, and held off during the pulse processing time, it is possible to eliminate the need for a pulse pile-up rejection. We have achieved output counting rates significantly greater than with conventional operation for equivalent shaping networks. No significant degradation in spectrometer resolution was observed at the increased counting rates.
Orbit and coset analysis of the Golay and related codes (1990)

Let b be a code of length n over a field F, with automorphism group G; b/sub w/ denotes the subset of codewords of weight w. The goal is to classify the vectors of F/sup n/ into orbits under G and to determine their distances from the various subcodes b/sub w/. This is done for the first-order Reed-Muller, Nordstrom-Robinson, and Hamming codes of length 16, the Golay and shortened Golay codes of lengths 22, 23, 24, and the ternary Golay code of length 12.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The subunit structure of methylmalonyl-CoA mutase from <i>Propionibacterium shermanii</i> (1986)

5'-Deoxyadenosylcobalamin-dependent methylmalonyl-CoA mutase was purified to homogeneity from Propionibacterium shermanii by a simplified procedure. The native enzyme has an apparent Mr of 165,000, similar to the enzyme from other sources but larger than previously reported. It consists of two non-identical subunits, of Mr 79,000 and 67,000 respectively. The smaller subunit is apparently not a proteolytic fragment of the larger one. The final preparation usually contained some inactive mutase, bearing a tenaciously bound cobalamin species. This protein proved to be readily separable from apoenzyme by fast protein liquid chromatography on anion-exchange columns.
A non-resonant, frequency up-converted electromagnetic energy harvester from human-body-induced vibration for hand-held smart system applications (2014)

We present a non-resonant, frequency up-converted electromagnetic energy harvester that generates significant power from human-body-induced vibration, e.g., hand-shaking. Upon excitation, a freely movable non-magnetic ball within a cylinder periodically hits two magnets suspended on two helical compression springs located at either ends of the cylinder, allowing those to vibrate with higher frequencies. The device parameters have been designed based on the characteristics of human hand-shaking vibration. A prototype has been developed and tested both by vibration exciter (for non-resonance test) and by manual hand-shaking. The fabricated device generated 110 μW average power with 15.4 μW cm−3 average power density, while the energy harvester was mounted on a smart phone and was hand-shaken, indicating its ability in powering portable hand-held smart devices from low frequency (&lt;5 Hz) vibrations.
Gallium 67 citrate scanning and serum angiotensin converting enzyme levels in sarcoidosis. (1982)

Gallium 67 citrate scans and serum angiotensin converting enzyme (ACE) levels were obtained in 54 patients with sarcoidosis and analyzed in relation to clinical manifestations. 67Ga scans were abnormal in 97% of patients with clinically active disease (n = 30) and in 71% of patients with inactive disease (n = 24). Serum ACE levels were abnormally high (2 standard deviations above the control mean) in 73% of patients with clinically active disease and in 54% of patients with inactive disease. Serum ACE levels correlated significantly with 67Ga uptake score (r =.436; p less than .005). The frequency of abnormal 67Ga scans and elevated serum ACE levels suggests that inflammatory activity with little or no clinical expression is common in sarcoidosis. Abnormal 67Ga scans were highly sensitive (97%) but had poor specificity (29%) to clinical disease activity. The accuracy of negative prediction of clinical activity by normal scans (87%) was better than the accuracy of positive prediction of clinical activity by abnormal scans (63%). 67Ga scans can be used to support the clinical identification of inactive sarcoidosis.
Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2018)

Bill & Melinda Gates Foundation.
Robust precoding for orthogonal space-time block coded MIMO cognitive radio networks (2009)

We consider a spectrum sharing based cognitive radio wireless communications system which consists of a secondary transmitter (ST) and a secondary receiver (SR), both equipped with multiple antennas, and a single-antenna primary user (PU). ST is composed of an orthogonal space-time block code (OSTBC) followed by a linear precoder which acts as a multimode beamformer. Given a fixed OSTBC, our goal is to design a robust linear precoder, where the robustness assumes addressing the problem of imperfect channel state information (CSI) of ST to SR (ST-SR) MIMO link at ST. Channel correlation information of ST to PU (ST-PU) link is also available at ST. The imperfect channel knowledge of the ST-SR link is described by a specified uncertainty region, known to ST. The robust precoding design criterion is the maximization of the signal-to-noise ratio (SNR) for the worst-case Frobeneus norm-bounded CSI mismatch subject to the transmit-power constraint of ST and interference-power constraint of PU. The original robust precoder design problem is non-convex and does not have any close-form solution. Using a semidefinite relaxation (SDR) approach, we transform it to a convex form and find the approximate solution using standard numerical methods. Simulation results are presented to show the performance of the robust precoding scheme.
[Structural organization of DNA complexes with proteins HMGB1 and HMGB1-(A+B)]. (2008)

The interaction between DNA and the nonhistone proteins HMGB1 and HMGB1-(A+B) has been studied using circular dichroism and scanning force microscopy. The recombinant protein HMGB1-(A+B) has no negatively charged C-terminal domain characteristic for HMGB1. Our earlier suggestion about the structural interaction of tandem HMGB1-domains of the recombinant protein with DNA was confirmed. It was shown that the C-terminal part modulates the interactions of HMGB1-domains with DNA. Without the C-terminal sequence, the HMGB1-(A+B) protein forms DNA-protein complexes with the ordered supramolecular structure.
Robust optical coating design with evolutionary strategies (1996)

The optical performance of interference filters depends on systematic and statistical variations of the thicknesses and indices of refraction of the layers that occur during production and use. Assuming that their distributions are known, the expected performance can be optimized as a function of the nominal layer thicknesses with the help of strategies that mimic biological evolution. This results in filter designs that are easier to manufacture and more robust to use. The method is illustrated for color shifts that are rather sensitive to layer thickness variations. Its scope is entirely general, and it could be applied to other tolerancing problems that arise in optical design.
Rational unsharp masking technique (1998)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
The Bis(tricyclohexylstannyl) Sulfide Thionation of 3<i>H</i>-1,2,4- Triazol-3-ones (1987)

5-Aryl-2,4-dialkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones may be converted in 55-74% yield to the corresponding 3H-1,2,4-triazole-3-thiones by using the combination bis(tricyclohexylstannyl) sulfide/boron trichloride.
Use of formamide to improve amplification of HLA DQ alpha sequences. (1991)

Dot-blot analysis of DNA amplified by the polymerase chain reaction (PCR) using allele-specific oligonucleotide (ASO) probes promises to be a useful assay for identity and disease association studies. This laboratory is examining the amplification and typing of the HLA DQα gene as a possible means of forensic analysis. A kit for typing the DQα gene is now commercially available
A novel human interface of an omni-directional wheelchair (2005)

We propose a human interface of an omni-directional wheelchair based on "universal design". It aims convenient, flexible, simple and intuitive human interface without physical burdens for all users. We developed a novel human interface with touch panel display indicated the image which has an omni-directional seen from vision sensor attached on the center-top of the wheel chair. In our system, users can automatically move anywhere by only pushing the omni-view image. Our wheelchair also has the function of autonomous obstacle detection. Then, we compared the proposed system with a joystick, and questionnaire-based verification was conducted from some experiments.
Mechanical influence of cyclic stretch on vascular endothelial cells (2004)

See article by Von Offenberg Sweeney et al. [3] (pages 625–634) in this issue .

Most of the biological phenomena acting on arterial vessels are non-linear. The biological response of cells to mechanical stimuli differs substantially depending on whether they are exposed to static or pulsatile stress [1]. Since the first work by Glagov and his group [2], the role of cyclic hemodynamic forces has been emphasized. In the present issue, Von Offenberg Sweeney et al. [3] have studied the role of cyclic strain on the endothelial matrix metalloproteinase-2 expression and activity. They have also shown the importance of metalloproteinases within the frame of vascular remodeling and its consequences in clinical situations.

Endothelial cells (ECs) are mainly exposed to blood shear stress in the direction of blood flow but are also submitted to cyclical circumferential stretch that is tangential to the direction of blood flow. Pulsatile pressure is a major determinant of vessel stretch. Although the effects of cyclical mechanical stretch on vascular smooth muscle cells (SMCs) have been widely studied [4], its effects on ECs have received less attention and are the main focus of the work of Von Offenberg Sweeney et al. [3].

The authors used a Flexercell Stress Unit (Flexercell, USA) that mimics the effects of cyclic strain on cultured SMCs or ECs. This method permits the measurement of cellular elongation in response to deformation of the elastomere base of the culture plates. Other studies have used long-term organ cultures for arterial segments, which permits the application of physiological … 

*Tel.: +33 1 44 07 90 38; fax: +33 1 44 07 90 40. Email address: lacolley{at}ccr.jussieu.fr
Structure of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster (1987)

A 10.5-kilobase PstI endonuclease fragment encoding the entire Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster was cloned in Escherichia coli by transformation of a carB strain to uracil-independent growth. The cloned fragment also complemented E. coli pyrB, pyrC, pyrD, pyrE, and pyrF mutants. From the ability of subclones to complement E. coli pyr mutants, the gene order was deduced to be pyrBCADFE. The B. subtilis pyrB gene was shown to be expressed in E. coli, but synthesis of the enzyme was not repressible by the addition of uracil to the growth medium. The approximate molecular weights of the polypeptides encoded by B. subtilis pyrA, pyrB, pyrC, pyrD, pyrE, and pyrF were found to be 110,000, 36,000, 46,000, 34,000, 25,000, and 27,000, respectively.
Reproducibility of physiologic parameters obtained using functional computed tomography in mice (2004)

High-speed X-ray computed tomography (CT) has the potential to observe the transport of iodinated radio-opaque contrast agent (CA) through tissue enabling the quantification of tissue physiology in organs and tumors. The concentration of Iodine in the tissue and in the left ventricle is extracted as a function of time and is fit to a compartmental model for physiologic parameter estimation. The reproducibility of the physiologic parameters depend on the (1) The image-sampling rate. According to our simulations 5-second sampling is required for CA injection rates of 1.0ml/min (2) the compartmental model should reflect the real tissue function to give meaning results. In order to verify these limits a functional CT study was carried out in a group of 3 mice. Dynamic CT scans were performed on all the mice with 0.5ml/min, 1ml/min and 2ml/min CA injection rates. The physiologic parameters were extracted using 4 parameter and 6 parameter two compartmental models (2CM). Single factor ANOVA did not indicate a significant difference in the perfusion, in the kidneys for the different injection rates. The physiologic parameter obtained using the 6-parameter 2CM model was in line with literature values and the 6-parameter significantly improves chi-square goodness of fits for two cases.
Progression in Acute Stroke (1999)

This study suggests that the early clinical course of the neurological deficit after acute stroke is dependent on the initial stroke severity and that a dichotomy in early outcome exists surrounding an initial NIHSS score of 7. These findings may have significant implications for the design and patient stratification in treatment protocols with respect to primary clinical outcome.
Enhanced spontaneous emission from GaAs quantum wells in monolithic microcavities (1990)

Enhanced spontaneous emission has been observed with wavelength-sized monolithic Fabry–Perot cavities containing GaAs quantum wells. With an on-resonance cavity structure, the photoluminescence intensity increases in the cavity axis direction, and the spontaneous emission lifetime is experimentally found to decrease.
Therapeutic Inhibition of Angiogenesis (2003)

The idea of antiangiogenesis as a therapeutic strategy has been around for several decades (1). Vigorously pursued as a novel anticancer strategy (reviewed in (2-6), it is now widely considered to be a promising approach to the treatment of a range of pathologies of which uncontrolled vascular proliferation is a component (see Table 1). To date, therapeutic benefit has been achieved with antiangiogenic therapy in the treatment of life-threatening infantile hemangioma, pulmonary hemangiomatosis, and in the treatment of some vascular tumors (7,8). Table 1 Table 1 Pathologies Likely to Benefit from Therapeutic Intervention in Angiogenesis Excess angiogenesis Insufficient angiogenesis Arthritis Angiology Inflammatory, Vascular malformation Rheumatoid, Hemifacial micromia Kaposi's sarcoma Bone fracture nonunion Leukemia, lymphoma, and myeloma Chronic wounds Macular degeneration Ischemia/infarction Paget's disease Cerebral Psoriasis Intestinal Retinopathy (and its vascular complications) Myocardial Proliferative Peripheral Of prematurity Pyrogenic granuloma Solid carcinomas Ulcer Primary Duodenal Secondary (metastasis) Gastric Vascular tumors Hemangioma Capillary Juvenile (infantile) Hemangiomatosis Hemagioblastoma Other benign vascular proliferations.
Subsets of human CD4<sup>+</sup> regulatory T cells express the peripheral homing receptor CXCR3 (2011)

Regulatory T cells (Tregs) migrate into peripheral sites of inflammation such as allografts undergoing rejection, where they serve to suppress the immune response. In this study, we find that ∼30-40% of human CD25(hi) FOXP3(+) CD4(+) Tregs express the peripheral CXC chemokine receptor 3 (CXCR3) and that this subset has potent immunoregulatory properties. Consistently, we observed that proliferative responses as well as IFN-γ production were significantly higher using CXCR3-depleted versus undepleted responders in the mixed lymphocyte reaction, as well as following mitogen-dependent activation of T cells. Using microfluidics, we also found that CXCR3 was functional on CXCR3(pos) Tregs, in as much as chemotaxis and directional persistence towards interferon-γ-inducible protein of 10 kDa (IP-10) was significantly greater for CXCR3(pos) than CXCR3(neg) Tregs. Following activation, CXCR3-expressing CD4(+) Tregs were maintained in vitro in cell culture in the presence of the mammalian target of rapamycin (mTOR) inhibitor rapamycin, and we detected higher numbers of circulating CXCR3(+) FOXP3(+) T cells in adult and pediatric recipients of renal transplants who were treated with mTOR-inhibitor immunosuppressive therapy. Collectively, these results demonstrate that the peripheral homing receptor CXCR3 is expressed on subset(s) of circulating human Tregs and suggest a role for CXCR3 in their recruitment into peripheral sites of inflammation.
Evaluating Starches for Textile Purposes (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluating Starches for Textile PurposesWalter Schreiber and William StaffordCite this: Ind. Eng. Chem. Anal. Ed. 1942, 14, 3, 227–231Publication Date (Print):March 1, 1942Publication History Published online1 May 2002Published inissue 1 March 1942https://pubs.acs.org/doi/10.1021/i560103a011https://doi.org/10.1021/i560103a011research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Elastic and fracture properties of the two-dimensional triangular and square lattices (1994)

Lattice models are finding increasing use in modeling the elastic and fracture behaviour of inhomogeneous or multi-phase systems. The elastic and failure properties of a rotationally invariant formulation of the bond-bending model on the two-dimensional triangular (with first-neighbour couplings) and on a novel version of the square lattice (involving first- and second-neighbour couplings) are examined. Expressions for the elastic constants of the bond-bending model on the above mentioned lattices are given in terms of the two- and three-body force constants. The tensile failure surface of the bond-bending model on the triangular and square lattices is calculated, and displays some degree of anisotropy in both cases. The central-force model (with a zero bond-bending constant) on the triangular lattice shows the highest degree of anisotropy, namely 50%. The presence of the bond-bending coupling constant improves the degree of isotropy of the tensile failure surface for both the triangular and square lattices. It is therefore concluded that the role of the bond-bending coupling constant is to provide for a more uniform energy distribution among the bonds, so that preferential bond cleavage does not occur upon the application of stress.
Chromium, molybdenum, and tungsten: thermodynamic properties, chemical equilibriums, and standard potentials (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromium, molybdenum, and tungsten: thermodynamic properties, chemical equilibriums, and standard potentialsIngemar Dellien, F. M. Hall, and Loren G. HeplerCite this: Chem. Rev. 1976, 76, 3, 283–310Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/cr60301a001https://doi.org/10.1021/cr60301a001research-articleACS PublicationsRequest reuse permissionsArticle Views1361Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Characteristics of Adsorption Treatment of Cr(VI)-containing Wastewater using Kudzu as the Adsorbent (2008)

The kudzu has been investigated as an adsorbent for treatment of Cr(VI)-containing wastewater. The specific surface of kudzu was analyzed to be and its major composition were found to be nitrogen and oxygen. It was observed that adsorption reaction for Cr(VI) on kudzu meets 1st order in kinetics and Langmuir Model in equilibrium. As the pH of wastewater was increased, the adsorbed amount of Cr(VI) onto kudzu was increased due to the pre-combination of with adsorbent and the efficiency of adsorption was found to be 60% when real electroplating Cr(VI)-containing wastewater was applied.