gebhart/patrepeval huggingface dataset:
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis (2001)

The open environment of the eye is continuously subject to an influx of foreign agents that can activate complement. Decay-accelerating factor (DAF), membrane cofactor protein (MCP) and CD59 are regulators that protect self-cells from autologous complement activation on their surfaces. They are expressed in the eye at unusually high levels but their physiological importance in this site is unstudied. In the rat, a structural analogue termed 5I2 antigen (5I2 Ag) has actions overlapping DAF and MCP. In this investigation, we injected F(ab')2 fragments of 5I2 mAb into the conjunctiva and aqueous humor, in the latter case with and without concomitant blockage of CD59. Massive neutrophilic infiltration of the stroma and iris resulted upon blocking 5I2 Ag activity. Frank necrosis of the iris occurred upon concomitant intraocular blockage of CD59. C3b was identified immunohistochemically, and minimal effects were seen in complement-depleted animals and in those treated with non-relevant antibody. The finding that blockage of 5I2 Ag function in periocular tissues and within the eye causes intense conjunctival inflammation and iritis demonstrates the importance of intrinsic complement regulators in protecting ocular tissues from spontaneous or bystander attack by autologous complement.
Involvement of a cGMP-dependent Pathway in the Natriuretic Peptide-mediated Hormone-sensitive Lipase Phosphorylation in Human Adipocytes (2003)

Our previous studies have demonstrated that natriuretic peptides (NPs), peptide hormones with natriuretic, diuretic, and vasodilating properties, exert a potent control on the lipolysis in human adipocytes via the activation of the type A guanylyl cyclase receptor (1, 2). In the current study we investigated the intracellular mechanisms involved in the NP-stimulated lipolytic effect in human preadipocytes and adipocytes. We demonstrate that the atrial NP (ANP)-induced lipolysis in human adipocytes was associated with an enhanced serine phosphorylation of the hormone-sensitive lipase (HSL). Both ANP-mediated lipolysis and HSL phosphorylation were inhibited in the presence of increasing concentrations of the guanylyl cyclase inhibitor LY-83583. ANP did not modulate the activity of the cAMP-dependent protein kinase (PKA). Moreover, H-89, a PKA inhibitor, did not affect the ANP-induced lipolysis. On primary cultures of human preadipocytes, the ANP-mediated lipolytic effect was dependent on the differentiation process. On differentiated human preadipocytes, ANP-mediated lipolysis, associated with an increased phosphorylation of HSL and of perilipin A, was strongly decreased by treatment with the inhibitor of the cGMP-dependent protein kinase I (cGKI), Rp-8-pCPT-cGMPS. Thus, ANP-induced lipolysis in human adipocytes is a cGMP-dependent pathway that induces the phosphorylation of HSL and perilipin A via the activation of cGKI. The present study shows that lipolysis in human adipocytes can be controlled by an independent cGKI-mediated signaling as well as by the classical cAMP/PKA pathway.
Stability of Milk Gangliosides and Formation of G<sub>D3</sub>Lactone under Natural Acidic Conditions (1994)

Journal Article Stability of Milk Gangliosides and Formation of GD3 Lactone under Natural Acidic Conditions Get access Hiroshi Kawakami, Hiroshi Kawakami Technical Research Institute, Snow Brand Milk Products Co., Ltd., 1–1–2 Minamidai, Kawagoe, Saitama 350–11, Japan Search for other works by this author on: Oxford Academic Google Scholar Yumiko Ishiyama, Yumiko Ishiyama Technical Research Institute, Snow Brand Milk Products Co., Ltd., 1–1–2 Minamidai, Kawagoe, Saitama 350–11, Japan Search for other works by this author on: Oxford Academic Google Scholar Tadashi Idota Tadashi Idota Technical Research Institute, Snow Brand Milk Products Co., Ltd., 1–1–2 Minamidai, Kawagoe, Saitama 350–11, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 58, Issue 7, 1 January 1994, Pages 1314–1315, https://doi.org/10.1271/bbb.58.1314 Published: 01 January 1994 Article history Received: 01 November 1993 Published: 01 January 1994
Full-scale mixing, pumping and surface spreading trials of rock paste for filling mines (1988)

Abstract A stage in the development of a new, cheap and environmentally beneficial method of filling potentially dangerous abandoned mines with large voids in the West Midlands to prevent their collapse is outlined. The filling material, known as rock paste, consists of colliery spoil from tips mixed with water, prepared near the mine to be filled, pumped through long surface pipelines and down boreholes into the mine. It then spreads laterally long distances through the mines. Some details are given on the selection of suitable spoil, its processing into paste and its pumping behaviour through instrumented pipelines, up to 260 mm diameter and 220 m long, at high pressures and rates up to 80 m 3 /h. Some 1000 tonnes of spoil were pumped. Observations on the spreading performance of large heaps of paste pumped out on to a level surface, and one sloping at about 4°, demonstrate the capacity for paste to spread long distances through mines as a heavy plastic yielding material. The basic plastic spreading theory and its application to the design for a mine filling operation is outlined in the Appendix. Despite some shortcomings and recommendations for their improvement, the results of the trials were sufficiently encouraging for them to be applied to the trial filling of part of Castlefields Mine at Dudley.
Compression mode diagnosis enables high volume monitoring diagnosis flow (2006)

Diagnosis of scan test fail data plays a crucial role in enhancing ramp up of new CMOS technology generations. To enable faster feedback it is preferable to establish a monitoring diagnosis methodology on the production test floor. This paper reports result of a study on using test time optimized compressed scan technology and associated new algorithms for fault diagnosis. Data is based on a system-on-a-chip (SoC) product that is manufactured using Infineon Technologies' 130 nm process. A comparison with uncompressed scan test and diagnosis shows feasibility of implementing a monitoring diagnosis flow with compressed scan test serving the high throughput test flow.
Multicomponent Elastic Kirchoff Migration in TIV Media (1999)

Abstract With multicomponent seismic data acquisition, both compressional and shear waves can be measured directly.
Influence of<i>IL6R</i>rs8192284 Polymorphism Status in Disease Activity in Rheumatoid Arthritis (2010)

The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity.
A Review of Environmental Management Solutions for an Old, Unlined Landfill in Sydney, Australia (2003)

The decommissioned Astrolabe Park landfill, located in a suburb of Sydney, had an intermittent history of waste disposal dating back to 1938. The lack of an engineered barrier system to isolate the waste from the aquifer environment has resulted in the development of a leachate plume beneath and downgradient from the site. Starting shortly after waste disposal activities commenced, the leachate plume has been migrating from the landfill towards a shallow groundwater-fed pond (Lachlan Pond NO.5), into which the contaminated groundwater discharges. Beginning in 1990 a number of groundwater investigations have been undertaken at the site to characterise the extent of contamination associated with the landfill and the flux of contaminants between the landfill and the pond. The presence of leachate contamination requires the development of an environmental management strategy, and the sensitivity of the aquatic ecosystem of Lachlan Pond No.5 requires the adoption of a stringent level of protection. Traditional pump-and-treat systems are proven and reliable, but come at a high cost over the long term. Permeable reactive barriers and monitored natural attenuation are innovative new approaches and more cost effective, but both lack a well-documented performance record with respect to leachate plumes. Dredging along the shore of the pond would remove the accumulated silt and decaying organic material, facilitating the dilution of the plume in the pond and the removal of accumulated contaminants in the sediments. However, a risk assessment would be required to determine the impact to the aquatic ecosystem and pond water quality from the infiltrating leachate plume. The degree of risk minimisation will ultimately strike a balance between the funding available to the site owners and the regulatory requirements imposed.
Delay Model for Flooding of Service Prevention in E-Commerce System (2007)

Today's commercial security server systems which provide secrecy, integrity and availability is still be vulnerable to denial-of-service attacks. Authentication systems which use public key cryptography and process RSA encryption are relatively slow. This has become a major security threat specifically in flooding of service attacks caused by authentication requests. The service flooding attacks render the server incapable of providing its service to legitimate users. In this paper, we propose a delay protocol which applies to the authentication model. Our gradually strengthening authentication model improves the availability and continuity of services and prevents denial of service attacks. We implemented a flooding of service tolerance system to verify the efficiency of our model. This system will greatly increase the reliability.
Real-time knowledge-based support for air traffic management (1994)

Swissair, in collaboration with IBM, has developed a knowledge-based client/server system called Swissair Advanced Logical Tarmac Occupation (Salto). Salto is a real-time knowledge-based support system which is used at several airports to allocate aircraft to tarmac stands based on almost continuous updates from an existing host computer. The system alerts users to conflicts, proposes solutions, and plans for adjustments to flight schedules or special circumstances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Innovative Biomechanics for Directional Hearing in Small Flies (2001)

In humans and animals alike, the localization of sound constitutes a fundamental processing task of the auditory system. Directional hearing relies on acoustic cues such as the interaural amplitude and time differences and also, sometimes, the signal spectral composition. In small animals, such as insects, the auditory receptors are forcibly set close together, a design constraint imposing very short interaural distances. Due to the physics of sound propagation, the close proximity of the sound receivers results in vanishingly small amplitude and time cues. Yet, because of their directionality, small auditory systems embed original and innovative solutions that can be of inspirational value to some acute problems of technological miniaturization. Such ears are found in a parasitoid fly that acoustically locates its singing cricket host. Anatomically rather unconventional, the fly’s auditory system is endowed with a directional sensitivity that is based on the mechanical coupling between its two hemilateral tympanal membranes. The functional principle permitting this directionality may be of particular relevance for technological applications necessitating sensors that are low cost, low weight, and low energy. Based on silicon-etching technology, early prototypes of sub-millimeter acoustic sensors provide evidence for directional mechanical responses. Further developments hold the promise of applications in hearing aid technology, vibration sensors, and miniature video-acoustic surveillance systems.
Scalable Arbiters and Multiplexers for On-FGPA Interconnection Networks (2011)

Soft on-FGPA interconnection networks are gaining increasing importance since they simplify the integration of heterogeneous components and offer, at the same time, a modular solution to the complex system-wide communication issues. The switches are the basic building blocks of such interconnection networks and their design critically affects the performance of the whole network. The way data traverse each switch is governed by the operation of the arbiter and the crossbar's multiplexers that need to be efficiently mapped on the FPGA fabric under tight area and delay constraints. This paper explores the design space of an arbiter and a multiplexer as a unified entity and proposes two new circuit alternatives that allow the design of scalable soft FPGA switches.
Preparation and characterization of waterborne polyurethane/clay nanocomposite: Effect on water vapor permeability (2008)

Abstract A series of waterborne polyurethane (WBPU)/clay nanocomposite coating materials were prepared by prepolymer process with different clay contents (0–2 wt %). The study investigated surface structure as well as water resistance, thermal, mechanical, and water vapor permeability (WVP) of composite materials as a function of clay contents. The glass transition temperature of composite materials was higher than pristine WBPU and also increased with increasing clay contents. Thermal stability, and water resistance of the nanocomposite films also increased, when compared with pristine WBPU, and these properties increased with an increase in clay content. The maximum tensile strength was found with optimum clay content (1 wt %) of composite films. The WVP of coated nylon fabrics depend on the clay content and temperatures. The rate (%) of WVP of coated nylon fabrics decreased with increasing clay content at a fixed temperature. However, at a fixed clay content the WVP increased with the increase of temperatures. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
A<sub>2A</sub>antagonists as novel non-dopaminergic therapy for motor dysfunction in PD (2003)

The future management of Parkinson's disease (PD) requires pharmacologic agents that do not lose efficacy with disease progression or induce dyskinesia and that are free of other dopaminergic side effects. A2A receptor antagonists may provide an opportunity to introduce nondopaminergic management of PD. A2A receptors are selectively localized in basal ganglia and to the indirect output pathway where they control GABA and acetylcholine release. The A2A antagonists are effective in rodent models of PD, reversing motor deficits in haloperidol-treated, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated, or reserpinized mice, and potentiating L-dopa-induced rotation in 6-hydroxydopamine-lesioned rats without inducing dyskinesia. Importantly, the selective A2A antagonist KW6002 reverses motor disability and increases locomotor activity in MPTP-treated primates without provoking dyskinesia established by previous exposure to L-dopa. In addition, KW6002 shows additive antiparkinsonian activity with L-dopa and the D2 agonist quinpirole in MPTP-treated primates without enhancing the intensity of dyskinesia. The data available suggest that A2A antagonists, such as KW6002, may be effective as monotherapy for the management of PD and that they will also produce additional benefit when administered in combination with L-dopa or dopamine agonist therapy.
Immunoglobulin Prophylaxis in Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analysis (2008)

Because there is no advantage in terms of survival or infection prevention, IVIG does not have a role in HSCT.
Biomedical magnetic resonance technology (1989)

Part 1 Magnetic resonance fundamentals: historical concepts precession and alignment resonance and the rotating frame relaxation and chemical shift phase sensitive detection mathematical treatment problems. Part 2 Biomedical magnetic resonance: history of biomedical NMR the Fourier transform and spectroscopy projection-reconstruction imaging Fourier imaging methods echoes spatial localization mathematical treatment problems. Part 3 Magnets and magnetic fields: concerning magnets homogeneity concerning magnetic fields spherical harmonics and field plotting field correction imperfections and switched gradients further mathematics problems. Part 4 Signal and noise: Basic electronics - passive the principle of reciprocity body noise and power deposition matching and interference probe design practical points concepts - advanced and mathematical problem. Part 5 The transmitter and receiver: basic electronics - active the receiver the transmitter more advanced concepts problems. Part 6 Digital electronics and the computer: binary basics data transmission memory microprocessors the pulse programmer data conversion other peripherals problems. Part 7 Software and performance inprovements: languages and translators operating system user software drivers performance improvement advanced user software problems. Appendices: SI units constants resistance conventions bus standards codes answer to problems.
A new formulation for the design of Chebyshev arrays (1994)

A new formulation for the design of Chebyshev arrays is presented which makes no direct use of Chebyshev polynomials. The array factor is expressed in terms of cosine/cosine-hyperbolic functions based on which all analysis and design steps are carried out. Zeros of the array factor are used to obtain a system of equations for excitation currents. Solving this system of equations, current magnitudes are determined in terms of the current of one element chosen as the independent variable. A general formulation for an even or odd but otherwise arbitrary number of elements is presented. The minimum number of elements required to achieve the desired beamwidth and side lobe level is obtained in a single step without resorting to an iterative process. The optimum spacing between elements for broadside and end fire arrays is also addressed. Numerical results for example cases are provided.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Pelvic ring disruptions: effective classification system and treatment protocols. (1990)

From January 1, 1985, to September 10, 1988, 210 consecutive patients with high-energy pelvic ring disruptions (exclusive of acetabular fractures) were admitted to a statewide referral center for adult multiple trauma. They were treated by one of four attending orthopaedic traumatologists per protocol as determined by their injury classification and hemodynamic status; the injury classification system was based on the vector of force involved and the quantification of disruption from that force, i.e., lateral compression, anteroposterior compression, vertical shear, and combined mechanical injury. Of the 210 patients, 162 had complete charts: 126 (78.0%) were admitted directly from the scene, 110 (67.9%) were injured in motor vehicle or motorcycle accidents, 25 (15.0%) were admitted in shock (blood pressure less than 90 mm Hg), the average Glasgow Coma Score was 13.2, and the average Injury Severity Score was 25.8. Treatment of the pelvic fracture included the following methods (alone or in combination): acute external fixation (45.0; 28.0%), open reduction/internal fixation (22; 13.5%), acute arterial embolization (11; 7.0%), and bedrest (68; 42.0%). Overall blood replacement averaged 5.9 units (lateral compression, 3.6 units; anteroposterior compression, 14.8 units; vertical shear, 9.2 units; combined mechanical, 8.5 units). Overall mortality was 8.6% (lateral compression, 7.0%; anteroposterior, 20.0%, vertical shear, 0%; combined mechanical, 18.0%). The cause of death was associated with the pelvic fracture in less than 50%; no patient with an isolated or vertical shear pelvic injury died. We conclude that the predictive value of our classification system (incorporating appreciation of the causative forces and resulting injury patterns) and our classification-based treatment protocols reduce the morbidity and mortality related to pelvic ring disruption.
The Dietary Flavonoid Quercetin Increases VO2max and Endurance Capacity (2010)

Quercetin, a natural polyphenolic flavonoid substance present in a variety of food plants, has been shown in vitro and in animal studies to have widespread health and performance benefits resulting from a combination of biological properties, including antioxidant and anti-inflammatory activity, as well as the ability to increase mitochondrial biogenesis. Little is known about these effects in humans, however, especially with respect to exercise performance. The authors determined whether quercetin ingestion would enhance maximal aerobic capacity and delay fatigue during prolonged exercise in healthy but untrained participants. Twelve volunteers were randomly assigned to 1 of 2 treatments: (a) 500 mg of quercetin twice daily dissolved in vitamin-enriched Tang or (b) a nondistinguishable placebo (Tang). Baseline VO2max and bike-ride times to fatigue were established. Treatments were administered for a period of 7 days using a randomized, double-blind, placebo-controlled, crossover study design. After treatment both VO2max and ride time to fatigue were determined. Seven days of quercetin feedings were associated with a modest increase in VO2max (3.9% vs. placebo; p < .05) along with a substantial (13.2%) increase in ride time to fatigue (p < .05). These data suggest that as little as 7 days of quercetin supplementation can increase endurance without exercise training in untrained participants. These benefits of quercetin may have important implications for enhancement of athletic and military performance. This apparent increase in fitness without exercise training may have implications beyond that of performance enhancement to health promotion and disease prevention.
The Relative Proper Motion of G 167-29 in the Constellation Boötes (2012)

G 167-29 is a high proper motion star in the constellation Bootes. The study of the relative proper motion is pictured over an epoch of 97 years. Different sources will be used for recalculation the proper motion. The result of recalculation shows an improvement of proper motion which is given by μx = 0.100 / year for right ascension and μy = 0.337 / year for declination.
Generalized minimum aberration for asymmetrical fractional factorial designs (2001)

By studying treatment contrasts and ANOVA models, we propose a generalized minimum aberration criterion for comparing asymmetrical fractional factorial designs. The criterion is independent of the choice of treatment contrasts and thus model-free. It works for symmetrical and asymmetrical designs, regular and nonregular designs. In particular,it reduces to the minimum aberration criterion for regular designs and the minimum $G_2$-aberration criterion for two-level nonregular designs. In addition, by exploring the connection between factorial design theory and coding theory, we develop a complementary design theory for general symmetrical designs,which covers many existing results as special cases.