gebhart/patrepeval huggingface dataset:
Solubilisation and Molecular Characterisation of the P2X Purinoceptor (1993)

Conference Article| May 01 1993 Solubilisation and Molecular Characterisation of the P2X Purinoceptor JOSEPH SIMON; JOSEPH SIMON 1Molecular Neurobiology Unit, Division of Basic Medical Sciences, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK Search for other works by this author on: This Site PubMed Google Scholar XUENONG BO; XUENONG BO *Department of Anatomy and Developmental Biology and the Centre for Neuroscience, University College London, London WC1E 6BT, UK Search for other works by this author on: This Site PubMed Google Scholar GEOFFREY BURNSTOCK; GEOFFREY BURNSTOCK *Department of Anatomy and Developmental Biology and the Centre for Neuroscience, University College London, London WC1E 6BT, UK Search for other works by this author on: This Site PubMed Google Scholar ERIC A. BARNARD ERIC A. BARNARD 1Molecular Neurobiology Unit, Division of Basic Medical Sciences, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (2): 200S. https://doi.org/10.1042/bst021200s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation JOSEPH SIMON, XUENONG BO, GEOFFREY BURNSTOCK, ERIC A. BARNARD; Solubilisation and Molecular Characterisation of the P2X Purinoceptor. Biochem Soc Trans 1 May 1993; 21 (2): 200S. doi: https://doi.org/10.1042/bst021200s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Low-Temperature Si Epitaxy by Photochemical Vapor Deposition with SiH<sub>2</sub>Cl<sub>2</sub> (1994)

Epitaxial Si films were successfully grown by the mercury-sensitized photochemical vapor deposition (photo-CVD) method with SiH 2 Cl 2 at a substrate temperature of as low as 200° C. The electrical and optical properties of the obtained films were characterized by Hall measurement, IR and Raman spectroscopy and transmission electron microscopy. Furthermore, the n-type doping was carried out by the addition of PH 3 gas, and the electron concentration was varied from 10 16 cm -3 to 10 18 cm -3 by varying the PH 3 /SiH 4 gas ratio. It was found from the experiments that there was a strong correlation between the SiH 2 Cl 2 and H 2 flow rates for obtaining the epitaxial Si films at a low temperature.
A Writable Polypeptide–DNA Hydrogel with Rationally Designed Multi‐modification Sites (2014)

A polypeptide-DNA hydrogel is prepared by employing the “X”-shaped DNA assembling structure as crosslinker. The hydrogel can be modified with multifunctional components (here fluorescent molecules as a model) and possesses excellent self-healing and thixotropic properties, enabling the direct-writing of arbitrary 3D structures. This study provides a simple, universal strategy for the assembly of functionalized hydrogels.
Fampridine-SR in multiple sclerosis: a randomized, double-blind, placebo-controlled, dose-ranging study (2007)

Future studies should employ doses up to 20 mg twice daily with lower extremity strength and walking speed as potential outcome measures.
Self-sandwich Method. An Improved Immunoperoxidase Technic for the Detection of Small Amounts of Antigens (1980)

The unlabeled antibody peroxidase-antiperoxidase (PAP) sequence has been widely accepted as the most sensitive method for demonstrating antigens in paraffin sections. However, the results have been unpredictable in routine surgical specimens, with frequent false-negative stains. In order to amplify the staining reactions a self-sandwich method was used. The amplifier (antigen itself) was added after the application of specific antibody. The procedure may be repeated several times before the application of the bridge antiserum followed by PAP complexes. The method was designed to increase the number of antigen-antibody layers without increasing the number of heteroantisera in the system. Specimens derived from routine tonsillectomy were studied semi-quantitatively. Based on the number of positively stained Ig-containing cells in germinal centers, the sensitivity of the self-sandwich method was estimated to be 20 to 50 times that of the PAP method. In addition, extracellular Ig (reticular staining) and surface Ig were also stained positively in the germinal centers and lymphocytic mantles, respectively, but were not demonstrated by the PAP method. The enhancement of the sensitivity was achieved without compromising the specificity.
The Lanczos Method for Parameterized Symmetric Linear Systems with Multiple Right-Hand Sides (2010)

The solution of linear systems with a parameter is an important problem in engineering applications, including structural dynamics, acoustics, and electronic circuit simulations, and in related model order reduction methods such as Padé via Lanczos. In this paper, we present a Lanczos-based method for solving parameterized symmetric linear systems with multiple right-hand sides. We show that for this class of applications, a simple deflation method can be used.
Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation (2006)

Hepatitis C virus (HCV) infection is frequently associated with the development of hepatocellular carcinomas and non-Hodgkin's B-cell lymphomas. Previously, we reported that HCV infection causes cellular DNA damage and mutations, which are mediated by nitric oxide (NO). NO often damages mitochondria, leading to induction of double-stranded DNA breaks (DSBs) and accumulation of oxidative DNA damage. Here we report that HCV infection causes production of reactive oxygen species (ROS) and lowering of mitochondrial transmembrane potential (DeltaPsi(m)) in in vitro HCV-infected cell cultures. The changes in membrane potential could be inhibited by BCL-2. Furthermore, an inhibitor of ROS production, antioxidant N-acetyl-L-cysteine (NAC), or an inhibitor of NO, 1,400W, prevented the alterations of DeltaPsi(m). The HCV-induced DSB was also abolished by a combination of NO and ROS inhibitors. These results indicated that the mitochondrial damage and DSBs in HCV-infected cells were mediated by both NO and ROS. Among the HCV proteins, core, E1, and NS3 are potent ROS inducers: their expression led to DNA damage and activation of STAT3. Correspondingly, core-protein-transgenic mice showed elevated levels of lipid peroxidation and oxidatively damaged DNA. These HCV studies thus identified ROS, along with the previously identified NO, as the primary inducers of DSBs and mitochondrial damage in HCV-infected cells.
Two contrasting roles for Notch activity in chick inner ear development:specification of prosensory patches and lateral inhibition of hair-cell differentiation (2005)

Lateral inhibition mediated by Notch is thought to generate the mosaic of hair cells and supporting cells in the inner ear, but the effects of the activated Notch protein itself have never been directly tested. We have explored the role of Notch signalling by transiently overexpressing activated Notch (NICD) in the chick otocyst. We saw two contrasting consequences, depending on the time and site of gene misexpression: (1) inhibition of hair-cell differentiation within a sensory patch; and (2) induction of ectopic sensory patches. We infer that Notch signalling has at least two functions during inner ear development. Initially, Notch activity can drive cells to adopt a prosensory character, defining future sensory patches. Subsequently, Notch signalling within each such patch mediates lateral inhibition, restricting the proportion of cells that differentiate as hair cells so as to generate the fine-grained mixture of hair cells and supporting cells.
Single-user and multiuser adaptive maximal ratio transmission for Rayleigh channels (2000)

In maximal ratio transmission, the base station adjusts the complex weights of its transmit antennas to compensate for downlink channel gains in order to produce signal reinforcement-diversity-at a desired mobile that may have only a single antenna. To make the method adaptive, the complex weights are obtained from the instantaneous complex gains in the uplink; however, delay and frequency offset between uplink measurements and downlink transmission reduce the correlation between the gains in the two directions. This paper provides an analysis of the effects of gain decorrelation and of the number of antennas, and an assessment of the effect of fading when the method supports multiple users. It demonstrates that large reductions in downlink transmit power are achievable, and it examines simple transmission models to see how well they support the technique.
Integrin Inhibitor Suppresses Bevacizumab-Induced Glioma Invasion (2014)

Glioblastoma is known to secrete high levels of vascular endothelial growth factor (VEGF), and clinical studies with bevacizumab, a monoclonal antibody to VEGF, have demonstrated convincing therapeutic benefits in glioblastoma patients. However, its induction of invasive proliferation has also been reported. We examined the effects of treatment with cilengitide, an integrin inhibitor, on bevacizumab-induced invasive changes in glioma. U87ΔEGFR cells were stereotactically injected into the brain of nude mice or rats. Five days after tumor implantation, cilengitide and bevacizumab were administered intraperitoneally three times a week. At 18 days after tumor implantation, the brains were removed and observed histopathologically. Next, the bevacizumab and cilengitide combination group was compared to the bevacizumab monotherapy group using microarray analysis. Bevacizumab treatment led to increased cell invasion in spite of decreased angiogenesis. When the rats were treated with a combination of bevacizumab and cilengitide, the depth of tumor invasion was significantly less than with only bevacizumab. Pathway analysis demonstrated the inhibition of invasion-associated genes such as the integrin-mediated cell adhesion pathway in the combination group. This study showed that the combination of bevacizumab with cilengitide exerted its anti-invasive effect. The elucidation of this mechanism might contribute to the treatment of bevacizumab-refractory glioma.
MEMS scanning micromirror for optical coherence tomography (2014)

This paper describes an endoscopic-inspired imaging system employing a micro-electromechanical system (MEMS) micromirror scanner to achieve beam scanning for optical coherence tomography (OCT) imaging. Miniaturization of a scanning mirror using MEMS technology can allow a fully functional imaging probe to be contained in a package sufficiently small for utilization in a working channel of a standard gastroesophageal endoscope. This work employs advanced image processing techniques to enhance the images acquired using the MEMS scanner to correct non-idealities in mirror performance. The experimental results demonstrate the effectiveness of the proposed technique.
Foldable Textile Electronic Devices Using All‐Organic Conductive Fibers (2014)

Abstract Scalable conductive multifilament of poly(3,4‐ethylenedioxythiophene) doped with poly(4‐styrene sulfonate) (PEDOT:PSS) and poly(vinyl alcohol) (PVA) was fabricated by a coagulation of spinning dope solution in cold methanol. The multifilament was composed of uniform circular fibers with an average diameter of 60 ± 5 μm and showed good enough mechanical properties for textile processes while maintaining electronic conductivity. The PEDOT:PSS/PVA blended fibers displayed an actuation response when a voltage was applied in air and the foldable textiles based on the PEDOT:PSS/PVA blended fibers worked as flexible electrodes to detect human heartbeats. The organic conductive fibers can be a platform for lightweight wearable electronics.
On the approximability of the maximum feasible subsystem problem with 0/1-coefficients (2009)

Given a system of constraints li ≤ aTix ≤ ui, where ai ∈ {0, 1}n, and li, ui ∈ R+, for i = 1,..., m, we consider the problem Mrfs of finding the largest subsystem for which there exists a feasible solution x ≥ 0. We present approximation algorithms and inapproximability results for this problem, and study some important special cases. Our main contributions are:1. In the general case, where ai e {0, 1}n, a sharp separation in the approximability between the case when L = max{l1, ..., lm} is bounded above by a polynomial in n and m, and the case when it is not.2. In the case where A is an interval matrix, a sharp separation in approximability between the case where we allow a violation of the upper bounds by at most a (1 + e) factor, for any fixed e > 0 and the case where no violations are allowed.Along the way, we prove that the induced matching problem on bipartite graphs is inapproximable beyond a factor of Ω(n1/3-e), for any e > 0 unless NP=ZPP. Finally, we also show applications of Mrfs to some recently studied pricing problems.
Size and shape of nonionic amphiphile micelles: NMR self-diffusion and static and quasi-elastic light-scattering measurements on C12E5, C12E7, and C12E8 in aqueous solution (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSize and shape of nonionic amphiphile micelles: NMR self-diffusion and static and quasi-elastic light-scattering measurements on C12E5, C12E7, and C12E8 in aqueous solutionWyn Brown, Zhou Pu, and Roger RymdenCite this: J. Phys. Chem. 1988, 92, 21, 6086–6094Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/j100332a048https://doi.org/10.1021/j100332a048research-articleACS PublicationsRequest reuse permissionsArticle Views730Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Formal verification of a pipelined microprocessor (1990)

The application of modern functional languages and supporting verification technology to a scaled-down but realistic microprocessor is described. The model is of an infinite stream of machine instructions consuming an infinite stream of interrupt signals and is specified at two levels: instruction and hardware design. A correctness criterion is stated for an appropriate sense of equivalent behavior of these levels and proved using a mechanically supported induction argument. The functional-language-based verification system Clio and the Mini Cayuga microprocessor are described. The formal specification and verification process are examined in detail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Pilot Study of Focused Ultrasound Thalamotomy for Essential Tremor (2013)

In this pilot study, essential tremor improved in 15 patients treated with MRI-guided focused ultrasound thalamotomy. Large, randomized, controlled trials will be required to assess the procedure's efficacy and safety. (Funded by the Focused Ultrasound Surgery Foundation; ClinicalTrials.gov number, NCT01304758.).
Shear wave polarization survey using converted waves (1987)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1987Shear wave polarization survey using converted wavesAuthors: Robert J. GarottaPierre MarechalRobert J. GarottaCGG, France and Pierre MarechalCGG Canada Ltd.https://doi.org/10.1190/1.1892020 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1892020FiguresReferencesRelatedDetailsCited ByAdvances in the detection and compensation of birefringenceRobert Garotta, Pierre‐Yves Granger, and Halim Dariu7 December 2005A review of shear wave splitting in the crack-critical crustGeophysical Journal International, Vol. 155, No. 1COMPARISON OF SIGNAL PROCESSING TECHNIQUES FOR ESTIMATING THE EFFECTS OF ANISOTROPY1Geophysical Prospecting, Vol. 39, No. 3 SEG Technical Program Expanded Abstracts 1987ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1987 Pages: 923 publication data© 1987 Copyright © 1987 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 07 Mar 2005 CITATION INFORMATION Robert J. Garotta and Pierre Marechal, (1987), "Shear wave polarization survey using converted waves," SEG Technical Program Expanded Abstracts : 657-658. https://doi.org/10.1190/1.1892020 Plain-Language Summary PDF DownloadLoading ...
Gold Nanoparticle Embedded, Self-Sustained Chitosan Films as Substrates for Surface-Enhanced Raman Scattering (2004)

In this work, self-sustained, biocompatible, biodegradable films containing gold nanostructures have been fabricated for potential application in nanobioscience and ultrasensitive chemical and biochemical analysis. We report a novel synthesis of gold nanoparticles mediated by the biopolymer chitosan. Self-supporting thin films are formed from the resultant gold-chitosan nanocomposite solutions and characterized by UV-visible surface plasmon absorption, transmission electron microscopy, atomic force microscopy, infrared absorption, and Raman scattering measurements. Results demonstrate control over the size and distribution of the nanoparticles produced, which is promising for several applications, including the development of biosensors. As a proof of principle, we demonstrate that gold-chitosan films can be employed in trace analysis using surface-enhanced Raman scattering.
Data signaling functions for a cellular mobile telephone system (1977)

The Bell System is proposing to provide high capacity mobile telephone service in the 850-MHz band via a cellular system that employs frequency reuse within a geographic area. In this system, mobile units respond to orders received from base station sites, which are in turn controlled by data links from a telephone central office. Since all phases of the mobile telephone call, including call setup, handoff between base stations, and disconnect require extensive data signaling, a reliable data transmission facility must exist between the central office and the mobile units. The transmission facility consists of a land link and a radio link. The reliability of the radio transmission path is relatively low, and therefore error control techniques are necessarily more elaborate for the radio link than for the land link. Descriptions are given of the signaling requirements and of the signaling schemes devised for both the switching office-to-base station land path and base station-to-mobile unit radio path. The anticipated performance of the error control procedures for these paths is also presented.
A shape memory alloy-based tendon-driven actuation system for biomimetic artificial fingers, part I: design and evaluation (2008)

SUMMARY In this paper, a new biomimetic tendon-driven actuation system for prosthetic and wearable robotic hand applications is presented. It is based on the combination of compliant tendon cables and one-way shape memory alloy (SMA) wires that form a set of agonist–antagonist artificial muscle pairs for the required flexion/extension or abduction/adduction of the finger joints. The performance of the proposed actuation system is demonstrated using a 4 degree-of-freedom (three active and one passive) artificial finger testbed, also developed based on a biomimetic design approach. A microcontroller-based pulse-width-modulated proportional-derivation (PWM-PD) feedback controller and a minimum jerk trajectory feedforward controller are implemented and tested in an ad hoc fashion to evaluate the performance of the finger system in emulating natural joint motions. Part II describes the dynamic modeling of the above nonlinear system, and the model-based controller design.
The <i>N</i>1→<i>N</i>2 Migration of the <i>s</i>-Triazinyl Group of 4-Substituted <i>N</i>1,<i>N</i>1-Bis-(<i>s</i>-triazinyl)-<i>o</i>-phenylenediamines (1972)

Abstract Several 4-substituted N1-[bis-(diethylamino)-s-triazinyl]-N1-(dimethoxy-s-triazinyl)-o-phenylenediamines were synthesized, and the migrations of the s-triazinyl group were investigated in these compounds. In methanol, every 4-substituted N1,N1-bis(s-triazinyl)-o-phenylenediamine gave only 4-substituted N1-[bis-(diethylamino)-s-triazinyl]-N2-(dimethoxy-s-triazinyl)-o-phenylenediamine by the migration of the dimethoxy-s-triazinyl group; the rearrangement was assumed to proceed through an intramolecular nucleophilic attack by the ortho amino group upon the ring carbon of the dimethoxy-s-triazinyl group. However, in the presence of a small amount of acid, the N1→N2 migration of the bis(diethylamino)-s-triazinyl group occurred preferentially, and two kinds of rearranged products were obtained. The kinetics of the rearrangement have also been studied spectrophotometrically in methanol, and the effects of the substituents on the rearrangement have been discussed.