gebhart/patrepeval huggingface dataset:
An historical review of quality control in hematology. (1983)

As the use of laboratory techniques in diagnostic medicine increase, it became obvious that standardized reference methods and stable controls were essential in order for results obtained in different laboratories to be comparable. Certain procedures and standards have been adopted to provide QC in hematology. Currently procedures include the following: cyanmethemoglobin for HGB determinations; particle counter for RBC and WBC counts; phase microscopy for PLT counts; and packed cell volume for HCT determinations. These serve as acceptable reference methods for multichannel hematology instruments. Instruments that are used must be carefully calibrated. Calibration of the spectrophotometer should be performed using an acceptable standard for hemoglobin. Calibration of the particle counter to determine RBC and WBC counts should be performed using a fresh sample of anticoagulated (EDTA) blood. PLT counting by phase hemacytometry should be used to obtain reference values for automated PLT counters. Centrifuges that are used to obtain microhematocrit values should be calibrated for maximum packing times and times checked against an electric clock. After the instruments have been calibrated, fresh whole blood is measured to determine a target value for each determination. Primary calibration of multichannel instruments is performed by calibrating each parameter to the target value. This is performed initially and then once each week. Two techniques that are commonly used to monitor instrument performance are: 1) the use of at least two levels of commercially prepared control samples to prepare either Levey-Jennings charts or the simple Cusum charts, which detect presymptomatic instrument problems; and/or 2) the use of 500-1,000 patient indices and mean WBC counts analyzed by the XB statistic to establish limits for monitoring instrument performance.
Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding (2010)

Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To explore the evolution of gene regulation, we used chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) to determine experimentally the genome-wide occupancy of two TFs, CCAAT/enhancer-binding protein alpha and hepatocyte nuclear factor 4 alpha, in the livers of five vertebrates. Although each TF displays highly conserved DNA binding preferences, most binding is species-specific, and aligned binding events present in all five species are rare. Regions near genes with expression levels that are dependent on a TF are often bound by the TF in multiple species yet show no enhanced DNA sequence constraint. Binding divergence between species can be largely explained by sequence changes to the bound motifs. Among the binding events lost in one lineage, only half are recovered by another binding event within 10 kilobases. Our results reveal large interspecies differences in transcriptional regulation and provide insight into regulatory evolution.
Theoretical study of the conformations and electronic structures of phenylene-pyrrole and phenylene-furan copolymers (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical study of the conformations and electronic structures of phenylene-pyrrole and phenylene-furan copolymersSung Y. Hong and Dennis S. MarynickCite this: Macromolecules 1992, 25, 13, 3591–3595Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ma00039a045https://doi.org/10.1021/ma00039a045research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Description of Portsmouth (1959)

Journal Article Description of Portsmouth Get access Maurice Line Maurice Line 1The University Library, Southampton Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 6, Issue 10, 1 November 1959, Page 419, https://doi.org/10.1093/nq/6.10.419b Published: 01 November 1959
Security for Wireless Sensor Networks using Identity-Based Cryptography (2012)

Security for Wireless Sensor Networks using Identity-Based Cryptography introduces identity-based cryptographic schemes for wireless sensor networks. It starts with an exhaustive survey of the existing layered approach to WSN security-detailing its pros and cons. Next, it examines new attack vectors that exploit the layered approach to security.Aft
Light and Scanning Electron Microscopy of Exfoliated Bladder Epithelial Cells in Rats Fed N -[ 4-(5-Nitro-2-furyl)-2-thiazolyl]formamide 2 3 (1976)

Urine specimens obtained periodically from weanling male F344 rats fed 0.2% N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) for 25 weeks followed by control diet for an additional 35 weeks, were examined by light microscopy (LM) and scanning electron microscopy (SEM). LM revealed red blood cells and atypical transitional cells in the urine at 25 and 43 weeks, when microinvasive transitional cell carcinoma was present. Malignant transitional cells were seen in the urine by LM at 60 weeks, when muscle invasion was present in histologic sections. However, SEM showed pleomorphic microvilli on exfoliated urothelial cells as early as 10 weeks after the beginning of FANFT administration, and the microvilli became increasingly pleomorphic as the bladder lesions progressed to muscle invasion at 60 weeks. Noninvasive tumors were present in histologic sections of rat bladders examined at the end of 10 weeks of FANFT administration. The numerous microvilli on exfoliated bladder tumor cells were in sharp contrast to the peaked microridges of normal exfoliated superficial cells.
Mechanical properties of transparent funcional thin films for flexible displays (2003)

The present work investigates the mechanical integrity of multilayer films developed for flexible displays. The layers comprise tin-doped indium oxide (ITO) conductive coatings and alumina barrier coatings sputtered onto high temperature aromatic polyesters. The onset strain for tensile failure and related cohesive strength of the coatings, and their adhesion to the polymer substrate, are analyzed by means of bending tests and fragmentation tests. The former test enables accurate electrical resistivity measurements during bending of film specimens, and correlates the failure of the ITO coating to the abrupt increase of resistivity. In the fragmentation test, the progressive failure of the thin coating is examined in situ in an optical microscope as a function of tensile strain, with simultaneous measurement of the electrical resistance, for the ITO coatings. The results and their analysis enable to determine the influence of internal stresses and layer thickness on the failure mechanisms of the multilayer composite films, despite the occurrence of coupled failure processes between adjacent layers.
Recent Advances in Bifunctional Catalysts for the Fischer–Tropsch Process: One-Stage Production of Liquid Hydrocarbons from Syngas (2019)

Fischer–Tropsch (FT) synthesis is an important reaction for the alternative production of high-quality liquid fuels, which promote sustainable development by enabling economical decarbonization. The one-stage FT process involves both hydrocarbon growth and hydrocracking/isomerization in a single step and is more energy and cost efficient than the two-stage process. Bifunctional catalysts, composed of acid and metal sites, are needed in order to achieve one-step synthesis. In this review, we discuss the state of the art concerning the use of bifunctional catalysts for the one-stage FT process, focusing on the effect of metal and acid sites on the catalytic performance. Several supports with potential utility for the one-stage FT process were analyzed, including zeolites, clays, alumina, silica, aluminosilicates, and carbons, and the advantages and disadvantages of each are evaluated.
Suramin binds to platelet‐derived growth factor and inhibits its biological activity (1985)

The polyanion suramin was recently found to inhibit binding of 125I-PDGF (platelet-derived growth factor) to Balb/c 3T3 cell membranes. Cultured Swiss 3T3 cells were used to investigate the mode of action of suramin and to monitor its effect on the biological activity of PDGF. Evidence is presented that suramin inhibits cellular binding of PDGF by binding to PDGF itself, thereby preventing it from binding to its cell surface receptor: First, while suramin inhibited 125I-PDGF binding with a half maximum inhibition concentration of approximately 60 microM or 90 micrograms/ml in a simultaneous competition assay, it was inactive in a sequential radioreceptor assay, in which an inhibitor is expected to be active if it interacts with the receptor (even with relatively low affinity) but to be inactive if it interacts with PDGF. Second, suramin prevented immunoprecipitation of 125I-PDGF in a dose-dependent manner, with a half maximum effective concentration of approximately 50 microM. Furthermore, suramin efficiently dissociated 125I-PDGF bound to its cell surface receptor, whereas unlabeled PDGF even in large excess was virtually inactive. This is also in line with the proposed direct interaction between PDGF and suramin, since such an interaction can be envisaged to induce a conformational change in the PDGF-receptor complex, resulting in an increased off-rate of the complex. Reduced 125I-PDGF binding in the presence of suramin correlated directly with a suramin dose-dependent inhibition of PDGF-induced incorporation of 3H-thymidine into quiescent Swiss 3T3 cells and of the proliferation of these cells.(ABSTRACT TRUNCATED AT 250 WORDS)
A study of over 35,000 women with breast cancer tested with a 25‐gene panel of hereditary cancer genes (2017)

These results demonstrate that panel testing increased the number of women identified as carrying a PV in this cohort compared with BRCA testing alone. Furthermore, the proportion of women identified who carried a PV in this cohort did not decrease between ages 40 and 59 years. Cancer 2017;123:1721-1730. © 2017 American Cancer Society.
Preliminary Field Results on a New Transient Induction System Employing Pseudo-Noise Signals (1974)

An experimental system is described which utilizes pseudo-noise (PN) and cross-correlation techniques to characterize subsurface conducting bodies such as those pertaining to natural resources. The system is essentially an extension of the loop-loop, transient-electromagnetic, induction systems used in ore prospecting. In lieu of a low duty-cycle pulse, this system transmits a wide-bandwidth PN digital waveform. The mapping signature is obtained by cross-correlation of the received signal with a replica of the sounding PN waveform. The receiver also averages several signatures to improve the signal-to-noise ratio. This type of system has the potential advantages over previous transient systems of using smaller antennas and requiring less transmitter power for more portable operation. Preliminary field data is shown and discussed for a high conductivity dike of ilmenite magnetite and for the surrounding low conductivity anorthosite. Frequency response data is obtained digitally via the Discrete Fourier Transform operation on the time domain signatures. Interpretations are given for both time and frequency domain representations.
<title>Arthroscopic knee surgery using the advanced flat panel high-resolution color head-mounted display</title> (1997)

The first ever deployed arthroscopic knee surgeries have been performed using a high resolution color head-mounted display (HMD) developed under the DARPA Advanced Flat Panel HMD program. THese procedures and several fixed hospital procedures have allowed both the system designers and surgeons to gain new insight into the use of a HMD for medical procedures in both community and combat support hospitals scenarios. The surgeons demonstrated and reported improved head-body orientation and awareness while using the HMD and reported several advantages and disadvantages of the HMD as compared to traditional CRT monitor viewing of the arthroscopic video images. The surgeries, the surgeon's comments, and a human factors overview of HMDs for Army surgical applications are discussed here.
Studies on the Mechanism of B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>‐Catalyzed Hydrostannylation of Propargylic Alcohol Derivatives (2012)

Doppelter H-Verlust: Die Lewis-Säure B(C6F5)3 katalysiert die regio- und stereoselektive Hydrostannylierung von Propargylalkoholen (siehe Schema). Zunächst abstrahiert sie ein Hydrid vom Stannan unter Bildung eines Borhydrid/Stannylkation-Paars, dessen Stabilität von Solvens und Liganden abhängt. Deuteriummarkierung zeigt, dass das Alkenylkation sein Hydrid im nächsten Schritt nicht vom Borhydrid, sondern von einem zweiten Stannanmolekül erhält. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Nonpharmacological Intervention to Improve Sleep in Nursing Home Patients: Results of a Controlled Clinical Trial (2005)

This multicomponent, nonpharmacological intervention conducted by trained research staff had no effect on nighttime sleep in this sample of nursing home patients. Enhanced nonpharmacological interventions should be developed and tested and combined with environmental interventions to mitigate noise when feasible. Adjunctive drug therapy may be needed to improve sleep in a substantial proportion of this population and should be tested in addition to nonpharmacological interventions in rigorous clinical trials.
Expression of myosin isozymes during the developmental stage and their redistribution induced by pressure overload. (1986)

Cardiac muscles contain at least two isozymes--referred to as alpha(HC alpha) and beta(HC beta)--of the myosin heavy chain. The proportional ratio of these isozymes varies depending upon the developmental stage and the physiological and/or the hormonal milieu of the cell. Using monoclonal antibodies (MoAb) specific for human cardiac HC alpha and HC beta, we have examined the expression of these isozymes in fetal through adult cardiac tissues and investigated whether isozymic redistribution occurs in pressure overloaded human ventricles. We found that although HC alpha was expressed in the atrium from the early embryonic stage, in embryonic ventricular myofibers, only HC beta was expressed without expression of HC alpha, but some myofibers replace HC beta by HC alpha after birth, and these HC alpha containing ventricular myofibers were found to be decreased by pressure overload, which suggested that isozymic redistribution from HC alpha to HC beta also occurred in the ventricles, as well as the atrium. In addition, we also found two subtypes of HC beta (beta 1, beta 2) in the human heart. In the ventricle, both beta 1 and beta 2 was present in all myofibers; in contrast, some myofibers contained beta 1 or beta 2 or both with or without expression of HC alpha in the atrium. beta 1 and beta 2 were distinctive in their expression during the developmental stage, since beta 1 was present in the embryonic heart from the early developmental stage, whereas beta 2 was not present in the early embryonic heart, but began to be expressed in the late embryonic stage.(ABSTRACT TRUNCATED AT 250 WORDS)
Regional brain responses associated with drinking water during thirst and after its satiation (2014)

The instinct of thirst was a cardinal element in the successful colonization by vertebrates of the dry land of the planet, which began in the Ordovician period about 400 million y ago. It is a commonplace experience in humans that drinking water in response to thirst following fluid loss is a pleasant experience. However, continuing to drink water once thirst has been satiated becomes unpleasant and, eventually, quite aversive. Functional MRI experiments reported here show pleasantness of drinking is associated with activation in the anterior cingulate cortex (Brodmann area 32) and the orbitofrontal cortex. The unpleasantness and aversion of overdrinking is associated with activation in the midcingulate cortex, insula, amygdala, and periaqueductal gray. Drinking activations in the putamen and cerebellum also correlated with the unpleasantness of water, and the motor cortex showed increased activation during overdrinking compared with drinking during thirst. These activations in motor regions may possibly reflect volitional effort to conduct compliant drinking in the face of regulatory mechanisms inhibiting intake. The results suggestive of a specific inhibitory system in the control of drinking are unique.
Lipid Composition of Brewer's Yeast (2001)

The lipid fraction of the Saccharamyces uvarum yeast obtained as a by-product of industrial beer production was analyzed in order to evaluate nutritive and potential pharmacological properties of the yeast biomass. Total lipids accounted for 4.4 % of dry biomass, 58 % of which were neutral lipids. Mono-, di- and tri triacylglycerols, squalene, lanosterol, ergosterol, steryl esters and free fatty acids were identified in the neutral lipid fraction. Squalene was by far the most abundant one making up 56 % of neutral lipids and 33 % of total lipids, respectively. The main phospholipid component was phosphatidylcholine. Saturated fatty acids predominated in the compositon of total and neutral lipids, while in the polar lipid fraction the contents of saturated and unsaturated fatty acids were almost the same. In all three fractions palmitic acid was present in the highest amount. Fatty acid composition of phospholipid classes differed significantly. Although brewer's yeast does not belong to the so-called lipid yeasts, the high content of squalene gives reason for additional exploitation of this by-product of the brewing industry.
Polymer Doping for High‐Efficiency Perovskite Solar Cells with Improved Moisture Stability (2017)

Abstract Each component layer in a perovskite solar cell plays an important role in the cell performance. Here, a few types of polymers including representative p‐type and n‐type semiconductors, and a classical insulator, are chosen to dope into a perovskite film. The long‐chain polymer helps to form a network among the perovskite crystalline grains, as witnessed by the improved film morphology and device stability. The dewetting process is greatly suppressed by the cross‐linking effect of the polymer chains, thereby resulting in uniform perovskite films with large grain sizes. Moreover, it is found that the polymer‐doped perovskite shows a reduced trap‐state density, likely due to the polymer effectively passivating the perovskite grain surface. Meanwhile the doped polymer formed a bridge between grains for efficient charge transport. Using this approach, the solar cell efficiency is improved from 17.43% to as high as 19.19%, with a much improved stability. As it is not required for the polymer to have a strict energy level matching with the perovskite, in principle, one may use a variety of polymers for this type of device design.
Can Big Companies Become Successful Venture Capitalists (1998)

Maybe, but first they need to understand what makes the model work Four good reasons to try... pick only one It's hardly surprising that big companies are attracted to the venture capital (VC) model for new business development.(*) Its track record is enviable: the industry as a whole outperformed the SP to look for business concepts that will excel if the industry evolves as they believe it will; and, most important, to insist on the presence of a strong management team. Although corporate managers often have just as clear a strategic focus in their core business, they typically run into greater ambiguity with venture programs. Their biggest challenge is to establish clear, prioritized objectives. Simply making a good financial return is unlikely to be sufficient, while other objectives - acquiring new technologies, entering new markets, reenergizing corporate culture - often compete for attention. Moreover, corporate managers are unlikely to receive the regular exposure to new ideas that VC firms enjoy, and the criteria they use to evaluate ideas are often intolerant of the risks inherent in launching a new type of business. Willingness to weed out the losers... Venture capital firms view each funding decision not as a project approval but as an option on future decisions. They reduce their exposure by investing in small increments until the key risk factors are resolved. With only one in ten ventures becoming a hit, VC firms manage their portfolios ruthlessly, weeding out likely losers early. …
The Structure and Properties of the Dialkyl Phosphonates. (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure and Properties of the Dialkyl Phosphonates.G. O. Doak and Leon D. FreedmanCite this: Chem. Rev. 1961, 61, 1, 31–44Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://doi.org/10.1021/cr60209a002Request reuse permissionsArticle Views1184Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts