gebhart/patrepeval huggingface dataset:
Bioinspired Peptide-Decorated Tannic Acid for in Situ Remineralization of Tooth Enamel: In Vitro and in Vivo Evaluation (2017)

Tooth enamel can be eroded by the local cariogenic bacteria in plaque or nonbacterial factors in the oral environment. The damage is irreversible in most situations. For the etched human tooth enamel to be restored in situ, a salivary-acquired pellicle (SAP) bioinspired tannic acid (SAP-TA) is synthesized. Statherin is one of the SAP proteins that can selectively adsorb onto enamel surface. Peptide sequence DDDEEKC is a bioinspired sequence of statherin and has the adsorption capacity of hydroxyapatite (HAP). TA has abundant polyphenol groups that can grasp Ca<sup>2+</sup> in saliva to induce the regeneration of HAP crystal. Hence, SAP-TA not only enhances the binding force at the interface of remineralization but also mimics the biomineralization process of tooth enamel. Moreover, ferric ion can coordinate with SAP-TA to form a compact coating that increases the adsorbed amounts of SAP-TA on tooth enamel. Compared with SAP-TA alone, the etched enamels treated with SAP-TA/Fe(III) have a better remineralization effect and mechanical properties (surface microhardness recovery >80% and binding force of 64.85 N) when being incubated in artificial saliva for 2 weeks. In vivo remineralization performance is evaluated in a classical rat caries model. The polarizing microscope and micro-CT results show that SAP-TA/Fe(III) has a good effect on the remineralization process in a real oral environment, indicating that it is a promising repair material for in situ remineralization of enamel.
Automatic scoliosis detection based on local centroids evaluation on moire topographic images of human backs (2001)

This paper presents a technique for automating human scoliosis detection by computer based on moiré topographic images of human backs. Scoliosis is a serious disease often suffered by teenagers. For prevention, screening is performed at schools in Japan employing a moiré method in which doctors inspect moiré images of subjects' backs visually. The inspection of a large number of moiré images collected by the school screening causes exhaustion of doctors and leads to misjudgment. Computer-aided diagnosis of scoliosis has, therefore, been requested eagerly by orthopedists. To automate the inspection process, unlike existent three-dimensional techniques, displacement of local centroids is evaluated two-dimensionally between the left-hand side and the right-hand side of the moiré images in the present technique. The technique was applied to real moiré images to draw a distinction between normal and abnormal cases. According to the leave-out method, the entire 120 image data (60 normal and 60 abnormal) were separated into three data sets. The linear discriminant function based on Mahalanobis distance was defined on the two-dimensional feature space employing one of the data sets containing 40 moiré images and classified 80 images in the remaining two sets. The technique finally achieved the average classification rate of 88.3%.
Fiber optic sensor for chlorinated hydrocarbons in water based on infrared fibers and tunable diode lasers (1993)

A novel fiber optic evanescent wave spectroscopy (FEWS) system is based on a tunable diode laser (TDL) source, on a polymer-coated AgClBr infrared transmitting fiber, and on a mercury cadmium telluride detector. This system was used for sensing low levels of chlorinated hydrocarbons in water. The detection limit was 100 μg/ℓ (100 ppb), which is an improvement by a factor of 50 in comparison to a similar system that is based on a Fourier transform infrared spectrometer, and the measurement time was reduced by a factor of 3. The TDL-FEWS system shows significant potential for in situ monitoring of ground water.
Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells. (1977)

Human peripheral blood mononuclear cells (lymphocyte-monocyte) in culture release a solube factor which can stimulate, up to 200-fold, production of prostaglandin E2 by isolated, adherent, rheumatoid synovial cells. Production of the factor by the mononuclear cells is enhanced by phytohemagglutinin. This factor is similar in apparent mol vt (10,000-20,000) to that which also stimulates collagenase production by the same cells.
Computational Gene Prediction Using Multiple Sources of Evidence (2004)

This article describes a computational method to construct gene models by using evidence generated from a diverse set of sources, including those typical of a genome annotation pipeline. The program, called Combiner, takes as input a genomic sequence and the locations of gene predictions from ab initio gene finders, protein sequence alignments, expressed sequence tag and cDNA alignments, splice site predictions, and other evidence. Three different algorithms for combining evidence in the Combiner were implemented and tested on 1783 confirmed genes in Arabidopsis thaliana. Our results show that combining gene prediction evidence consistently outperforms even the best individual gene finder and, in some cases, can produce dramatic improvements in sensitivity and specificity.
A 0.115 μm/sup 2/ 8F/sup 2/ DRAM working cell with LPRD (low parasitic resistance device) and poly metal gate technology for gigabit DRAM (2002)

An 8F/sup 2/ stack DRAM cell, 0.115 /spl mu/m/sup 2/ in size, has been successfully integrated using a selective epitaxial plug scheme for landing plug contacts and poly metal gates and MIM COB capacitors, by which cell working has been proven under easy function check mode. The cell transistor exhibits sufficient saturation current (I/sub OP/) of >40 /spl mu/A with threshold voltage (V/sub tsat/) of 1.0 V.
Managing full waveform LiDAR data: A challenging task for the forthcoming years (2008)

6 pages
Artificial feeding and patients' rights: recent developments and recommendations. (1988)

The rejection of technologically supplied nutrition and hydration (artificial feeding) has emerged in the last five years as one of the most controversial aspects of the right to refuse treatment. This article summarizes the trends in the legal and medical literature recognizing that individuals have the right to reject artificial feeding as to refuse any other medical treatment. It also addresses non-legal concerns and offers recommendations for effective implementation of patient preferences.
Odour concentration affects odour identity in honeybees (2005)

The fact that most types of sensory stimuli occur naturally over a large range of intensities is a challenge to early sensory processing. Sensory mechanisms appear to be optimized to extract perceptually significant stimulus fluctuations that can be analysed in a manner largely independent of the absolute stimulus intensity. This general principle may not, however, extend to olfaction; many studies have suggested that olfactory stimuli are not perceptually invariant with respect to odour intensity. For many animals, absolute odour intensity may be a feature in itself, such that it forms a part of odour identity and thus plays an important role in discrimination alongside other odour properties such as the molecular identity of the odorant. The experiments with honeybees reported here show a departure from odour-concentration invariance and are consistent with a lower-concentration regime in which odour concentration contributes to overall odour identity and a higher-concentration regime in which it may not. We argue that this could be a natural consequence of odour coding and suggest how an 'intensity feature' might be useful to the honeybee in natural odour detection and discrimination.
Shortcut Mining: Exploiting Cross-Layer Shortcut Reuse in DCNN Accelerators (2019)

Off-chip memory traffic has been a major performance bottleneck in deep learning accelerators. While reusing on-chip data is a promising way to reduce off-chip traffic, the opportunity on reusing shortcut connection data in deep networks (e.g., residual networks) have been largely neglected. Those shortcut data accounts for nearly 40% of the total feature map data. In this paper, we propose Shortcut Mining, a novel approach that “mines” the unexploited opportunity of on-chip data reusing. We introduce the abstraction of logical buffers to address the lack of flexibility in existing buffer architecture, and then propose a sequence of procedures which, collectively, can effectively reuse both shortcut and non-shortcut feature maps. The proposed procedures are also able to reuse shortcut data across any number of intermediate layers without using additional buffer resources. Experiment results from prototyping on FPGAs show that, the proposed Shortcut Mining achieves 53.3%, 58%, and 43% reduction in off-chip feature map traffic for SqueezeNet, ResNet-34, and ResNet152, respectively and a 1.93X increase in throughput compared with a state-of-the-art accelerator.
Device for Projecting Image of Reading Scale (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevice for Projecting Image of Reading ScaleClifton. Tuttle and F M. BrownCite this: Ind. Eng. Chem. Anal. Ed. 1944, 16, 10, 645Publication Date (Print):October 1, 1944Publication History Published online1 May 2002Published inissue 1 October 1944https://pubs.acs.org/doi/10.1021/i560134a023https://doi.org/10.1021/i560134a023research-articleACS PublicationsRequest reuse permissionsArticle Views16Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Total Synthesis of Guanacastepene A: A Route to Enantiomeric Control (2005)

[reaction: see text] The goal of the total synthesis of guanacastepene A served as a focus to bring together several chemical inquiries. One involved the synthesis of fused 5,7-hydrazulenones (see structure 20). Another issue had to do with the mechanistic intermediates in reductive cyclizations (see 17 to 18 and 19). The total synthesis required a mastery of an intramolecular Knoevenagel condensation of a beta,gamma-unsaturated ketone (see compound 41). Actually, cyclization was best accomplished when the terminal double bond of 41 was first converted to an epoxide. Further issues related to the stereochemistry at C5 and, rather surprisingly, the propensity for beta-face acetoxylation at C13. Crystallographic verification of the assigned beta-stereochemistry at C13 is provided. Finally, a route to optically active material is provided (see compound 20). A key element in this construction was an enantioselective addition of isopropenyl cuprate to 2-methylcyclopentenone (see compound 99).
Heterogeneity in interleukin (IL)-1 receptors expressed on human B cell lines. Differences in the molecular properties of IL-1 alpha and IL-1 beta binding sites. (1990)

IL-1 alpha and IL-1 beta although distantly related at the primary sequence level, bind to the same Mr 80,000 IL-1 receptor on various cell types. Several lines of evidence indicate, however, that the IL-1 receptor on B cells and T cells differ. By binding experiments with 125I-IL-1, marked heterogeneity in IL-1 receptor binding was observed in 13 of 24 B cell lines studied. This was classified into three categories: (I) in nine cell lines, 125I-IL-1 alpha binding revealed high (kD = 10(-10) M) and low affinity (kD = 10(-8) M) IL-1 alpha receptors, whereas 125I-IL-1 beta binding showed one class only with intermediate affinity (kD = 10(-9) M); (II) in three cell lines selective binding with 125I-IL-1 beta was observed; (III) in one cell line only, 125IL-1 alpha and 125I-IL-1 beta bind to a single class of IL-1 receptors as has been described for most cell types. Cross-linking with 125I-IL-1 alpha or 125I-IL-1 beta demonstrated their specific binding to Mr 80,000 and to Mr 68,000 in cell lines in categories I and III, whereas for those in category II, binding to the IL-1 receptor was confined to 125I-IL-1 beta. The expression of two subsets of IL-1 alpha receptors but only one class of IL-1 beta receptors was further confirmed in kinetic studies. Internalization at 37 degrees C demonstrated that only 19% of IL-1 beta was internalized and that binding with IL-1 alpha was entirely cell surface. Flow cytometry studies showed that IL-1 alpha and IL-1 beta do not influence B cell surface antigen expression, suggesting that the ability of IL-1 to influence B cell proliferation is not mediated via direct binding to the IL-1 receptor only.
Overhead infrared vehicle sensor for traffic control (2002)

An experimental infrared optical system has been designed to detect and monitor vehicular road traffic. The system was developed and tested in the laboratory using infrared laser sources and detectors in conjunction with computerized signal processing and correlation techniques. Preliminary road tests confirm the system's capability to detect and monitor vehicular road traffic. The test results indicate that a product based on the technology developed may be cost effective, weather resistant, and have the potential for more sophisticated applications, including vehicle speed measurement and length classification.
Non‐alcoholic steatohepatitis: What is it, and why is it important in the Asia–Pacific region? (2003)

Non-alcoholic steatohepatitis (NASH), is a critical link in the chain of metabolic fatty liver disorders that spans steatosis to cryptogenic cirrhosis. It is the hepatic manifestation of the insulin resistance (or metabolic) syndrome, and provides a clue to understanding fibrotic progression of other chronic liver diseases, particularly hepatitis C. Non-alcoholic steatohepatitis is often the first clinical indication of insulin resistance, with its complications of high blood pressure, coronary heart disease and type 2 diabetes. Among those with risk factors, NASH is common: present in at least 20% of obese adults or children with or without type 2 diabetes, and at least 5% of those overweight. With emerging urbanization, increasing affluence and behavioral changes of physical inactivity and high fat/energy-excessive diet, type 2 diabetes has become common in Asia and the western Pacific rim. The rates range from 7-40%, which in countries like Japan represents a 3-20-fold increase (depending on age) over the last 20 years. The increase is associated with central adiposity, insulin resistance, hepatic steatosis and NASH. After cancer, cirrhosis from NASH is now the second most common age-related cause of death in type 2 diabetes. Reversing these trends must become a public health priority; the first awakenings were evident in Taiwan at the time of this meeting. In order to stimulate clinicians to think more about the importance of metabolic liver disease for development of cirrhosis, this review will cover clinical and laboratory features, natural history and an approach to diagnosis and management of NASH. Some emerging concepts on pathogenesis will be mentioned briefly, but the emphasis will be on the potency of lifestyle adjustments (physical activity and diet) to prevent or reverse fatty liver disorders.
Spontaneous hydrolysis of sulfonyl fluorides (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpontaneous hydrolysis of sulfonyl fluoridesMary E. Aberlin and Clifford A. BuntonCite this: J. Org. Chem. 1970, 35, 6, 1825–1828Publication Date (Print):June 1, 1970Publication History Published online1 May 2002Published inissue 1 June 1970https://pubs.acs.org/doi/10.1021/jo00831a024https://doi.org/10.1021/jo00831a024research-articleACS PublicationsRequest reuse permissionsArticle Views692Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analog Beamforming With Low Resolution Phase Shifters (2017)

In this letter, we consider analog beamforming using low resolution phase shifters for millimeter waves communications. We propose a hierarchical codebook design, where the beamforming vectors in the codebook are grouped into multiple levels and the preferred beamforming vector at each level is constructed to approximate an amplitude beamforming gain mask by using a low complexity local search algorithm. We show, by simulations, that the proposed codebook using low resolution phase shifters outperforms the existing schemes using high resolution phase shifters.
Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions <i>in vivo</i> (2008)

Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as schizophrenia, and they also can be induced by the use or abuse of certain drugs. The heptahelical serotonin 2A receptors (5-HT2ARs) are molecular targets for drug-induced hallucinations. However, the cellular mechanisms by which the 5-HT2AR mediates these effects are not well understood. Drugs acting at the 5-HT2AR can trigger diverse signaling pathways that may be directed by the chemical properties of the drug. beta-arrestins are intracellular proteins that bind to heptahelical receptors and represent a point where such divergences in ligand-directed functional signaling could occur. Here we compare the endogenous agonist, serotonin, to a synthetic 5-HT2AR hallucinogenic agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), in mice lacking beta-arrestin-2, as well as in cells lacking beta-arrestins. In mice, we find that serotonin induces a head twitch response by a beta-arrestin-2-dependent mechanism. However, DOI invokes the behavior independent of beta-arrestin-2. The two structurally distinct agonists elicit different signal transduction and trafficking patterns upon activation of 5-HT2AR, which hinge on the presence of beta-arrestins. Our study suggests that the 5-HT2AR-beta-arrestin interaction may be particularly important in receptor function in response to endogenous serotonin levels, which could have major implications in drug development for treating neuropsychiatric disorders such as depression and schizophrenia.
The Church Times.' (1913)

Journal Article The Church Times.' Get access John Collins Francis John Collins Francis Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s11-VII, Issue 165, 22 February 1913, Pages 141–143, https://doi.org/10.1093/nq/s11-VII.165.141 Published: 22 February 1913
Zinc regulates the ability of Cdc25C to activate MPF/cdk1 (2007)

Zn(2+) is an essential micronutrient for the growth and development of multicellular organisms, as Zn(2+) deficiencies lead to growth retardation and congenital malformations (Vallee, BL, Falchuk, KH. 1993. Physiol Rev., 73:79-118). At the cellular level Zn(2+) depravation results in proliferation defects in many cell types (Vallee, BL, Falchuk, KH. 1993. Physiol Rev., 73:79-118), however the molecular pathways involved remain poorly defined. Here we show that the transition metal chelator TPEN (N,N,N',N'-tetrakis(2-pyridylmethyl) ethylene diamine) blocks the G2/M transition of the meiotic cell cycle by inhibiting Cdc25C-cdk1 activation. ICP-MS analyses reveal that Cdc25C is a Zn(2+)-binding metalloprotein, and that TPEN effectively strips Zn(2+) away from the enzyme. Interestingly, although apo-Cdc25C (Zn(2+)-deficient) remains fully catalytically active, it is compromised in its ability to dephosphorylate and activate MPF/cdk1. Thus, Zn(2+) is an important regulator of Cdc25C function in vivo. Because of the conserved essential role of the Cdc25C-cdk1 module in the eukaryotic cell cycle, these studies provide fundamental insights into cell cycle regulation.
Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation (2007)

Coupling with fibroblasts affects the myocyte resting potential and the impulse propagation, but microstructural changes and myocyte decoupling are needed to explain slow conduction in fibrotic tissue.
VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN IS CAPABLE OF PROTECTING XENOENDOTHELIAL CELLS FROM ANTIBODY BINDING AND KILLING BY HUMAN COMPLEMENT AND CYTOTOXIC CELLS1 (2001)

VCP is a novel protein amongst the complement control protein family and can, not only block xenorejection by inhibiting complement but also by blocking killing by cytotoxic cells.
Structural Concepts and Aerodynamic Analysis for Low Radar Cross Section (LRCS) Fuselage Configurations (1978)

Abstract : The objectives of this study were: (1) to develop structural concepts for three low radar cross section (LRCS) fuselage configurations constructed of conventional materials; (2) to determine the effects of these concepts on the weight, cost, fail-safety, and maintainability of the three configurations; (3) to compare these findings with those of a baseline UH-60A helicopter, and thus select the structural concept that is the lowest in weight and cost and the easiest to maintain; (4) to assess the application of advanced materials for each configuration; (5) to identify high technical risk areas; (6) to develop overall design tranding data for helicopters, using the three fuselage configurations of conventional and advanced materials; (7) to conduct an analytical investigation of the aerodynamic loads, vertical drag and mission performance of the three low radar cross section (LRCS) configurations; and (8) to compare these findings with those of the baseline UH-60 helicopter. Structural concepts developed for the three LRCS configurations showed that extensive reshaping, as exemplified by Configuration 2, would increase fuselage weight from that of the baseline UH-60A fuselage by 223 pounds and cost by 3.65 percent. When advanced materials were used, Configuration 2 decreased from the baseline fuselage weight and cost by 118 pounds and 3.98 percent respectively.