gebhart/patrepeval huggingface dataset:
Interventions for preventing oral candidiasis for patients with cancer receiving treatment (2002)

There is strong evidence, from randomised controlled trials, that drugs absorbed or partially absorbed from the GI tract prevent oral candidiasis in patient receiving treatment for cancer. There is also evidence that these drugs are significantly better at preventing oral candidiasis than drugs not absorbed from the GI.
Speaker verification based on the orthogonalisation technique (1995)

This paper describes an investigation into text-dependent speaker verification using orthogonal feature parameters of speech. The study is based on the use of a subset of the BT Millar speech database, consisting of repetitions of digit utterances 1 to 9 and zero spoken by 20 male speakers. Sets of orthogonal parameters are obtained through a linear transformation of linear prediction, parcor, and cepstrum coefficients. It is demonstrated that amongst these, orthogonal cepstrum parameters possess the highest speaker discrimination ability. Based on the experimental results it is shown that for single-digit inputs, a minimum equal error rate of about 4% in verification can be achieved. This error rate is found to reach 0.95% when a sequence of five digits is used as the input. The experiments are discussed in detail, and an analysis of the results is presented.
<i>K</i>α X-Ray Emission Spectra and<i>K</i>X-RayAbsorption-Edge Structures of Fluorinein 3<i>d</i>Transition-Metal Difluorides (1991)

The fluorine K α emission spectra in fluorescence from a series of 3 d transition-metal difluorides MF 2 (M=Mn, Fe, Co, Ni, Cu and Zn) have been measured with a high-resolution two-crystal vacuum spectrometer. It is shown that the observed FWHM of the K α 1,2 emission band is closely related to the difference in the electronegativity between the metal and fluorine atoms. The measured emission spectra are presented along with the UPS or XPS spectra of the valence bands and the fluorine K absorption spectra of the metal difluorides, reported previously. The structures at the fluorine K absorption edges are interpreted in terms of a molecular orbital (MO) model.
Efficacy of two calcium phosphate pastes on the remineralization of artificial caries: a randomized controlled double-blind in situ study (2013)

To test the efficacy of two calcium phosphate pastes compared to that of fluoride toothpaste on remineralizing artificial caries in situ, this study had a double-blind crossover in situ design, involving three experimental phases of 14 days each, with an 8-day washout period between phases. Nine healthy subjects participated in the study. The subjects wore removable palatal appliances mounted with six human enamel slabs with artificial caries lesions, and in each of the experimental phases, used one of the following methods two times/day: group A, brushing with 1.0 g of Colgate Regular Flavor, followed by applying 0.25 g of Tooth Mousse Plus; group B, brushing with 0.25 g of Clinpro Tooth Crème; and group C, brushing with 1.0 g of Colgate Regular Flavor. After 14 days, the enamel slabs (54 slabs/group) were embedded in resin, sectioned and examined with a polarized-light microscope, and the lesion areas were quantified using Image-Pro Plus. All experimental groups showed a significant reduction in lesion area compared to the initial lesion area (paired t-test, P<0.001). The mean reduction in lesion area of Groups A, B and C were (0.029±0.010), (0.030±0.009) and (0.027±0.009) mm(2), respectively. There were no statistical differences between groups (Kruskal-Wallis test, P>0.05). All three groups remineralized the enamel slab lesions, indicating model sensitivity to fluoride. Given the differences in usage amounts and treated regimens, Clinpro Tooth Crème provided similar benefits to the fluoride toothpaste; however, no additional benefit of Tooth Mousse Plus was observed when used in conjunction with the fluoride toothpaste.
Polarization Diversity Pulse-Pair Technique for Millimeter-WaveDoppler Radar Measurements of Severe Storm Features (1999)

The Polarization Diversity Pulse-Pair (PDPP) technique can extend simultaneously the maximum unambiguous range and the maximum unambiguous velocity of a Doppler weather radar. This technique has been applied using a high-resolution 95-GHz radar to study the reflectivity and velocity structure in severe thunderstorms. This paper documents the technique, presents an analysis of the first two moments of the estimated mean velocity, and provides a comparison of the results with experimental data, including PDPP images of high-vorticity regions in supercell storms.
Method for the Synthesis of Multi-Epitopic<i>Streptococcus</i><i>pyogenes</i>Lipopeptide Vaccines Using Native Chemical Ligation (2006)

The aim of this study was to investigate methods for the synthesis of highly pure, well-characterized analogues of the lipid core peptide (LCP) system. Difficulties synthesizing and purifying conventional LCP systems have led to the requirement for a technique to produce highly pure, LCP-based vaccines for potential use in human clinical trials. The current study describes methods for the attachment of lipophilic adjuvants onto multi-epitopic peptide vaccines. Described is the synthesis, using native chemical ligation, of a highly pure, tri-epitopic, group A streptococcal (GAS) lipopeptide vaccine candidate. Intranasal immunization of the described tri-epitopic GAS lipopeptide with the mucosal adjuvant cholera toxin B subunit induced high serum IgG antibody titers specific for each of the incorporated peptide epitopes.
The Dielectric Constant of Lubrication Oils (1998)

The purpose of the present study was to evaluate the ability of panoramic radiographs to demonstrate facial fractures. Radiographs of eighty-two patients were analyzed retrospectively in cases in which both panoramic and conventional skull radiographs were available. One hundred thirty fractures within the middle third of the facial skeleton were identified, excluding nasal and mandibular fractures. In 64 per cent of the cases structural alterations suggesting fracture were detectable on panoramic radiographs; however, the interpretation of fractures on panoramic radiographs was much less certain than on conventional skull radiographs. The use of panoramic radiographs alone was often inadequate for diagnosis of many fractures outside the mandible.
Michael adducts of vinyl sulfones — source for thiadiazoles, oxadiazoles and triazoles (2008)

Abstract magnified image A new and novel five membered heterocycles thiadiazoles, oxadiazoles and triazoles were prepared from methyl 4‐arylsulfonyl‐3‐arylbutyrate and methyl 4‐arylmethanesulfonyl‐3‐arylbutyrate.
Prying open the space for social work in the new millennium (2012)

Social work in the United Kingdom faces all manner of woes. Critical public inquiries, disgruntled users of the service, the bureaucratisation of practice, problems with recruitment, and the overhaul of training, all continue to reinforce a culture of pessimism. It has been suggested that social work in the United Kingdom stands at the crossroads where a decision must be made either to accept these depressing conditions as they are, or to challenge them by asserting a new future for a reinvigorated profession. The latter option is supported by the authors of this article because we share the view that as social workers we have available to us discursive freedom with which to analyse the profession’s contemporary ailments and to find a way through them based on a discourse of social justice. The idea and practice of discursive freedom can be captured in the heuristic notion of ‘space’ which the authors use here as a shared focus for analysing contemporary social work from four different critical perspectives. In this way a dialogue is promoted between theory and practice and within critical theory. In its method and its results this inquiry is still very much work-in-progress. This provisional quality sits comfortably with the notion of ‘space’ and gives rein to its recursive qualities. These qualities, it is argued, must lie at the heart of transformative social work.
The role of genetic variants in angiotensin I converting enzyme, angiotensinogen and the angiotensin II type-1 receptor in the pathophysiology of heart muscle disease (1995)

The cardiac vasculature and myocardium contain components of the renin-angiotensin system (RAS), which may regulate local growth and cellular function. Alterations in the expression or action of these components, which include angiotensin converting enzyme (ACE), angiotensinogen, and angiotensin II type-1 receptors, may contribute to the development of disease, such as hypertension, left ventricular hypertrophy, myocardial infarction, and end-stage heart failure. ACE is one RAS component found to have genetic variants associated with cardiovascular disease. Molecular variants in any of the RAS components may affect signalling pathways, possibly increasing the risk of heart failure. In addition, variants may exacerbate the deleterious effects of altered RAS expression on cardiac function. Genetic variation in RAS components may affect therapy with ACE inhibitors and receptor-blocking agents. Although at present there is no compelling reason to target molecular variations for treatment, a new era in selective pharmacological therapy for cardiovascular disease may be imminent.
LazyPIM: An Efficient Cache Coherence Mechanism for Processing-in-Memory (2016)

Processing-in-memory (PIM) architectures cannot use traditional approaches to cache coherence due to the high off-chip traffic consumed by coherence messages. We propose LazyPIM, a new hardware cache coherence mechanism designed specifically for PIM. LazyPIM uses a combination of speculative cache coherence and compressed coherence signatures to greatly reduce the overhead of keeping PIM coherent with the processor. We find that LazyPIM improves average performance across a range of PIM applications by 49.1 percent over the best prior approach, coming within 5.5 percent of an ideal PIM mechanism.
Sublingual Drug Delivery (2008)

The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation. Attempts have been made to deliver various pharmacologically active agents, such as cardiovascular drugs, analgesics, and peptides, across the sublingual mucosa. In this review, the anatomical structure, blood supply, biochemical composition, transport pathways, permeation enhancement strategies, in vitro/in vivo models, and clinical investigations for the sublingual route of drug delivery is discussed.
Military Social Influence in the Global Information Environment: A Civilian Primer (2010)

This article provides an overview of the role of social influence in modern U.S. military affairs. Many military strategists are now convinced that modern warfare is centered on a battle for public opinion, rather than a battle for physical terrain. As a result, new military periodic literature, texts, doctrine, and initiatives are increasingly likely to place social influence at the core of military operations. Unfortunately, this literature and doctrine is developing in a conversation that is almost completely independent of civilian university-based scholarly consideration. The goal of this civilian “primer” is to help bridge the gap between civilian and military scholarship by providing (1) an introduction to competing conceptions of the role of influence in modern war, (2) a brief description of current military initiatives using information operations, and (3) examples of influence tactics employed in recent U.S. military action. The article concludes by considering questions that modern military information operations raise about the intersection of social science, democracy, and war.
Sterols. XXIX. Urane Derivatives (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSterols. XXIX. Urane DerivativesRussell E. Marker, Oliver Kamm, Thomas S. Oakwood, Eugene L. Wittle, and Elmer J. LawsonCite this: J. Am. Chem. Soc. 1938, 60, 5, 1061–1066Publication Date (Print):May 1, 1938Publication History Published online1 May 2002Published inissue 1 May 1938https://pubs.acs.org/doi/10.1021/ja01272a022https://doi.org/10.1021/ja01272a022research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Combined Markov and Noise Clustering Modeling Method for Cell Phase Classification (2006)

Abstract: This paper proposes a classification method of cell nuclei in different mitotic phases using a combined Markov and noise clustering modeling technique. The method was tested with the data set containing 379519 cells in 892 cell sequences for 5 phases extracted from real image sequences recorded at every fifteen minutes with a time-lapse fluorescence microscopy. Experimental results showed that the proposed method performed better than the k-means modeling method.
Single-frame image processing techniques for low-SNR infrared imagery (2008)

Polaris Sensor Technologies, Inc. is identifying target pixels in IR imagery at signal to noise (SNR) ranges from 1.25 to 3 with a mixed set of algorithms that are candidates for next generation focal planes. Some of these yield less than 50 false targets and a 95% probability of detection in this low SNR range. What has been discovered is that single frame imagery combined with IMU data can be input into a host of algorithms like Neural Networks and filters to isolate signals and cull noise. Solutions for nonlinear thresholding approaches can be solved using both genetic algorithms and neural networks. What is being addressed is how to implement these approaches and apply them to point target detection scenarios. The large format focal planes will flood the down stream image processing pipelines used in real time systems, and this team wonders if data can be thinned near the FPA using one of these techniques. Delivering all the target pixels with a minimum of false positives is the goal addressed by the group. Algorithms that can be digitally implemented in a ROIC are discussed as are the performance statistics Probability of Detection and False Alarm Rate. Results from multiple focal planes for varied scenarios will be presented.
Enhancement of bacteriocin production and antimicrobial activity of Pediococcus acidilactici HA-6111-2 (2017)

The effect of sequential treatments of pressure (50–150 MPa, 10 ºC, 5 min) and temperature (57 ºC, 15 min) on the survival and bacteriocin production of Pediococcus acidilactici HA-6111-2 cells in the exponential growth phase was assessed. The growth curves were fitted with the modified Gompertz model, and the estimated maximum specific growth rate was considered to be pressure dependent. A delay in the maximum value of bacteriocin production was registered for more severe pressure conditions, but it was found more notorious for pressure followed by temperature treatments. At lower pressure intensity treatment, regardless of the application order, there was an enhancement of bacteriocin production per cell when compared to the control while maintaining the maximum production value. Bacteriocin production after the treatments can be described by an exponential model.
POMIRENJE I NEPOMIRLJIVOST U PRIČAMA PREŽIVJELIH POSLIJE RATA U BOSNI I HERCEGOVINI / RECONCILIATION AND IMPLACABILITY IN NARRATIVES OF SURVIVORS AFTER THE WAR IN BOSNIA AND HERZEGOVINA (2015)

Reason(s) for writing and research problem(s): Previous research on post-war society emphasized structural violence with subsequent reconciliation processes. Aims of the paper (scientific and/or social): Researchers have focused on the importance of narratives, but they have neither highlighted narratives about reconciliation nor analyzed conditions for reconciliation in post-war interviews. One aim of the article is analyzing markers for reconciliation and implacability, the second is describing conditions for reconciliation which are actualized in those stories. Methodology/Design: This article analyzes retold experiences of 27 survivors from the war in Bosnia and Herzegovina between 1992 and 1995. The material for the study was gathered through qualitative interviews with 27 individuals who survived the war in north-western Bosnia and Herzegovina. Research/paper limitations: Interactive dynamics which prevailed during the war associate post-war reconciliation with the war time. Results/Findings: These stories of reconciliation, implacability and conditions for reconciliation, are not created in relation to the war as a whole only but also in relation to one’s own and other’s personal actions during the war. General conclusion: These stories on reconciliation become a forum for confrontation between us and them – not least through dissociation from others war actions. In the interviewees stories implacability is predominant however reconciliation is said to be possible if certain conditions are met. These conditions are, among others, justice for war victims, that the perpetrators’ recognize their crimes and display strong emotions (for example remorse and shame).
Agonist-induced association of tropomyosin with protein kinase Cα in colonic smooth muscle (2004)

Smooth muscle contraction regulated by myosin light chain phosphorylation is also regulated at the thin-filament level. Tropomyosin, a thin-filament regulatory protein, regulates contraction by modulating actin-myosin interactions. Present investigation shows that acetylcholine induces PKC-mediated and calcium-dependent phosphorylation of tropomyosin in colonic smooth muscle cells. Our data also shows that acetylcholine induces a significant and sustained increase in PKC-mediated association of tropomyosin with PKCalpha in the particulate fraction of colonic smooth muscle cells. Immunoblotting studies revealed that in colonic smooth muscle cells, there is no significant change in the amount of tropomyosin or actin in particulate fraction in response to acetylcholine, indicating that the increased association of tropomyosin with PKCalpha in the particulate fraction may be due to acetylcholine-induced translocation of PKCalpha to the particulate fraction. To investigate whether the association of PKCalpha with tropomyosin was due to a direct interaction, we performed in vitro direct binding assay. Tropomyosin cDNA amplified from colonic smooth muscle mRNA was expressed as GST-tropomyosin fusion protein. In vitro binding experiments using GST-tropomyosin and recombinant PKCalpha indicated direct interaction of tropomyosin with PKCalpha. PKC-mediated phosphorylation of tropomyosin and direct interaction of PKCalpha with tropomyosin suggest that tropomyosin could be a substrate for PKC. Phosphorylation of tropomyosin may aid in holding the slided tropomyosin away from myosin binding sites on actin, resulting in actomyosin interaction and sustained contraction.
Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson^|^rsquo;s disease mouse model (2013)

Active oxygen has been implicated in the pathogenesis of Parkinson's disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural triterpene and an intermediate in the biosynthesis of cholesterol, is known to have active oxygen scavenging activities. Squalane, synthesized by complete hydrogenation of squalene, does not have active oxygen scavenging activities. We examined the effects of oral administration of squalene or squalane on a PD mouse model, which was developed by intracerebroventricular injection of 6-hydroxydopamine (6-OHDA). Squalene administration 7 days before and 7 days after one 6-OHDA injection prevented a reduction in striatal dopamine (DA) levels, while the same administration of squalane enhanced the levels. Neither squalene nor squalane administration for 7 days changed the levels of catalase, glutathione peroxidase, or superoxide dismutase activities in the striatum. Squalane increased thiobarbituric acid reactive substances, a marker of lipid peroxidation, in the striatum. Both squalane and squalene increased the ratio of linoleic acid/linolenic acid in the striatum. These results suggest that the administration of squalene or squalane induces similar changes in the composition of fatty acids and has no effect on the activities of active oxygen scavenging enzymes in the striatum. However, squalane increases oxidative damage in the striatum and exacerbates the toxicity of 6-OHDA, while squalene prevents it. The effects of squalene or squalane treatment in this model suggest their possible uses and risks in the treatment of PD.
A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes (2016)

Abstract Oral tongue squamous cell carcinomas (OTSCC) are a homogenous group of aggressive tumors in the head and neck region that spread early to lymph nodes and have a higher incidence of regional failure. In addition, there is a rising incidence of oral tongue cancer in younger populations. Studies on functional DNA methylation changes linked with altered gene expression are critical for understanding the mechanisms underlying tumor development and metastasis. Such studies also provide important insight into biomarkers linked with viral infection, tumor metastasis, and patient survival in OTSCC. Therefore, we performed genome-wide methylation analysis of tumors (N = 52) and correlated altered methylation with differential gene expression. The minimal tumor-specific DNA 5-methylcytosine signature identified genes near 16 different differentially methylated regions, which were validated using genomic data from The Cancer Genome Atlas cohort. In our cohort, hypermethylation of MIR10B was significantly associated with the differential expression of its target genes NR4A3 and BCL2L11 (P = 0.0125 and P = 0.014, respectively), which was inversely correlated with disease-free survival (P = 9E−15 and P = 2E−15, respectively) in patients. Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and epidemiologic parameters. Implications: This study reveals a functional minimal methylation profile in oral tongue tumors with associated risk habits, clinical, and epidemiologic outcomes. In addition, NR4A3 downregulation and correlation with patient survival suggests a potential target for therapeutic intervention in oral tongue tumors. Data from the current study are deposited in the NCBI Geo database (accession number GSE75540). Mol Cancer Res; 14(9); 805–19. ©2016 AACR.