gebhart/patrepeval huggingface dataset:
Clinical outcomes of patients with non-small cell lung cancer (NSCLC) receiving chemotherapy after immune checkpoint blockade. (2017)

9082 Background: Objective response rates (ORR) to chemotherapy beyond the first-line for advanced NSCLC are low (5-10%). Pre-clinical studies suggest that some chemotherapies may act, in part, through immune mediated mechanisms. Additionally, results from phase I/II studies of chemotherapy combined with immune checkpoint inhibitors (ICIs) suggest high response rates ( > 50%) and potential synergy. It is unknown whether chemotherapy is more efficacious when given after ICIs. Methods: We reviewed demographics, imaging, treatment history, and clinical course for all patients at our institution with a diagnosis of metastatic NSCLC who received at least one dose of nivolumab, pembrolizumab, atezolizumab, or durvalumab prior to December 8, 2016. Patients who received any subsequent chemotherapy were included for analysis. Objective response was determined by RECIST v1.1, and date of progression was determined radiographically or clinically (treatment discontinuation with documented clinical deterioration). Results: 145 patients received at least one dose of any ICI, and 38 patients received subsequent chemotherapy. The median age was 68 years (range 44-88). Six chemotherapy-naïve patients received carboplatin + pemetrexed +/- bevacizumab. There were 3 partial responses (PR) including one exceptional response that is ongoing after 2 years. Among 32 chemotherapy non-naïve patients, the median number of prior chemotherapy regimens was 2 (range 1-6). Post-ICI chemotherapy included docetaxel + ramucirumab (n = 12), vinorelbine (n = 7), gemcitabine-based chemotherapy (n = 6), carboplatin doublets (n = 4), pemetrexed + bevacizumab (n = 2), and paclitaxel (n = 1). Six patients had documented poor performance status and died within 1 month of starting treatment. The ORR was 25% (1CR, 7PR), median time to progression was 116 days, and 9 patients (28%) experienced stable disease (SD) or better lasting > 150 days. Exceptional responses occurred across regimens. Nine patients received a further line of chemotherapy, with 3 ongoing PR or SD lasting > 100 days. Conclusions: For NSCLC, chemotherapy response rates may be higher when administered after an ICI.
Ultra-broadband microwave metamaterial absorber (2012)

A microwave ultra-broadband polarization-independent metamaterial absorber is demonstrated. It is composed of a periodic array of metal-dielectric multilayered quadrangular frustum pyramids. These pyramids possess resonant absorption modes at multi-frequencies, of which the overlapping leads to the total absorption of the incident wave over an ultra-wide spectral band. The experimental absorption at normal incidence is above 90% in the frequency range of 7.8–14.7 GHz, and the absorption is kept large when the incident angle is smaller than 60°. The experimental results agree well with the numerical simulation.
Positional control of rotary servo cart system using generalized dynamic inversion (2018)

This paper presents the design approach of Generalized Dynamic Inversion (GDI) for angular position control of SRV02 rotary servo base system. In GDI, linear first order constraint differential equations are formulated based on the deviation function of angular position and its rate, and its inverse is calculated using Moore-Penrose Generalized Inverse to realize the control law. The singularity problem related to generalized inversion is solved by the inclusion of dynamic scaling factor that will guarantee the boundedness of the elements of the inverted matrix and stable tracking performance. Numerical simulations and real-time experiment are performed to evaluate the tracking performance and robustness capabilities of the proposed control law considering nominal and perturbed model dynamics. For comparative analysis, the results of GDI is compared with conventional PID control. Simulation and experimental results demonstrate better angular position tracking for the square-wave and sinusoidal waveforms, which reveals the superiority, and agility of GDI control over conventional PID.
NİFEDİPİN TEDAVİSİNE BAĞLI ORTAYA ÇIKAN (2006)

Nifedipin, arteriyal hipertansiyon ve angina pektoris tedavisinde s kl kla kullan lan bir ajand r. Nifedipine ba2l oral komplikasyonlar geli ebilir ki, bunlardan di eti büyümesi en önemlilerindendir. Bu çal ma, koronor arterlerin dilatasyonunda kullan lan önemli bir ilaç olan nifedipinin uzun dönem kullan m na ba2l geli en di eti büyümesi ikayetiyle klini2imize ba vuran bir bayan hastan n vaka raporudur. Vakada büyüyen di eti dokular n n cerrahi olarak uzakla t r lmasve dikkatli plak kontrolü ile ilac n kullan m n nkesilmesine gerek duyulmadan yeterli iyile mesa2lanm t r. Bu çal mada nifedipine ba2l geli en di eti büyümesinin klinik özellikleri, etiolojisi, ay r c tan s ve tedavisi, konuyla ili kili kaynaklar 2 nda tart lm t r
Whole body hyperthermia (41-42 degrees C) induces interleukin-1 in vivo. (1988)

The role of endogenous mediated fever and exogenous hyperthermia as modulators of immunological processes against infection and neoplasms remains poorly understood. Hyperthermia appears to modulate the activity of a number of immunological cytokines including Interleukin-1 (IL-1). Using a recently developed Radiant Heat technology for safely producing 41-42 degrees C Whole Body Hyperthermia in mice, we have investigated the effect of 1 hour of 41 +/- 0.5 degrees C WBH on the production of cutaneous IL-1. After a transient fall in IL-1 production 4 hours post WBH, significant elevations (up to twice control levels) were noted with a peak at 16-20 hours post WBH. IL-1 levels remained elevated for 5-6 days post-WBH. The potential clinical significance of this finding is discussed with particular reference to human malignant melanoma.
Spinal Pain Mechanisms (1997)

Pain is an extremely complex process that involves the interaction of an array of neurotransmitters and neuromodulators at all levels of the neuraxis. Identification of the receptors and processes that are involved in the transmission of pain at a spinal level has led to the use of new agents and new techniques in pain management. These include use of preemptive analgesia and use of techniques such as intrathecal drug administration and epidural spinal cord stimulation. This review presents some of the findings from basic research that have led to these developments, particularly those that relate to the changes that occur following inflammation and nerve injury.
Meanders and Frobenius Seaweed Lie Algebras (2011)

The index of a seaweed Lie algebra can be computed from its associated meander\ngraph. We examine this graph in several ways with a goal of determining families\nof Frobenius (index zero) seaweed algebras. Our analysis gives two new families\nof Frobenius seaweed algebras as well as elementary proofs of known families of\nsuch Lie algebras.
Demonstration of the heterogeneity of nucleoside diphosphokinase in rat tissues (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDemonstration of the heterogeneity of nucleoside diphosphokinase in rat tissuesYung-Chi Cheng, Bonnie Robison, and R. E. Parks, Jr.Cite this: Biochemistry 1973, 12, 1, 5–11Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/bi00725a002https://doi.org/10.1021/bi00725a002research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-γ and TRAIL (2004)

The majority of high-risk neuroblastomas lack the expression of caspase-8 due to gene silencing which suggest a mechanism for the selection of tumour cells that are refractory to multiple cytotoxic drugs including tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Inhibitors of DNA methyltransferases and IFN-gamma induce expression of caspase-8, and sensitise some neuroblastoma cells to TRAIL-mediated apoptosis. Here we demonstrate that a combination of cytostatic drugs with IFN-gamma and TRAIL synergistically induces neuroblastoma cell death, which may have implications for future therapy of children with neuroblastoma. Treatment of neuroblastoma cells with IFN-gamma induced caspase-8 expression in all cell lines investigated. In five of the neuroblastoma cell lines (SHEP-1, SK-N-AS, SK-N-FI, SH-SY-5Y and Kelly), IFN-gamma promoted TRAIL-mediated cleavage of caspase-8, initiating a caspase cascade involving caspase-7 and PARP followed by apoptosis. IFN-gamma-mediated facilitation of apoptosis was inhibited by the pan-caspase inhibitor zVAD-fmk and the caspase-8 specific inhibitor zIEDT-fmk, indicating an important role of caspase-8 in mediating sensitation by IFN-gamma in neuroblastoma cells. In three of the cell lines [SK-N-BE(2), SK-N-DZ and IMR-32] caspase-8 expression was induced by IFN-gamma, but the cells were still resistant to TRAIL-mediated apoptosis. The pattern of basal TRAIL receptor expression, decoy receptors, FLIP and FADD could not be correlated with resistance or sensitivity to TRAIL-induced apoptosis. Importantly, treatment of neuroblastoma cell lines with cytostatic drugs increased apoptosis in the TRAIL-sensitive cell lines whereas the resistant cell lines were susceptible to TRAIL-mediated apoptosis in the presence of the anticancer drugs. The mechanism of the increased susceptibility to apoptosis might results from drug-mediated up-regulation of the death receptors DR4 and DR5.
Identification and characterization of a “biomarker of toxicity” from the proteome of the paralytic shellfish toxin‐producing dinoflagellate <b><i>Alexandrium tamarense</i></b> (Dinophyceae) (2005)

The objective of this study was to identify and characterize a "biomarker of toxicity" from the proteome of Alexandrium tamarense, a paralytic shellfish toxin (PST)-producing dinoflagellate. A combination of 2-DE and MS approaches was employed to identify proteins of interest in the vegetative cells of several strains of A. tamarense with different toxin compositions and from different geographical locations. The electrophoretic analysis of the total water-soluble proteins from these toxic strains by 2-DE showed that several abundant proteins, namely AT-T1, AT-T2 and AT-T3, differing slightly in apparent Mr and pIs, were consistently present in all toxic strains of A. tamarense. Further analysis by MALDI-TOF MS and N-terminal amino acid sequencing revealed that they are isoforms of the same protein. Even more intriguing is that these proteins in A. tamarense have similar amino acid sequences and are closely related to a "biomarker of toxicity" previously reported in A. minutum. Unambiguous and highly species-specific identification was later achieved by comparing the PMFs of proteins in these two species. An initial attempt to characterize these proteins by generation of murine polyclonal antibodies against the AT-T1 protein was successful. Western blot analysis using the murine AT-T1-polycolonal antibodies identified all the toxic strains of A. tamarense and A. minutum, but not the nontoxic strain of A. tamarense. These results indicate that these protein characteristics for toxic strains are species-specific and that they are stable properties of the tested algae which are clearly distinguishable irrespective of geographical location and toxin composition. To our knowledge, this is the first study to demonstrate the use of polyclonal antibodies against marker proteins purified from 2-DE gels to distinguish different strains and species of the PST-producing dinoflagellate Alexandrium. It provides the basis for the production of monoclonal antibody probes against the "biomarkers of toxicity" for those dinoflagellates whose genome is incompletely characterized. Potentially, immunoassays could be developed to detect the presence of toxic algae in routine monitoring programs as well as to predict bloom development and movement.
Nonculture Methods for Diagnosing Chlamydial Infection in Patients with Trachoma: A Clue to the Pathogenesis of the Disease? (1988)

We studied five different tests for diagnosing conjunctival Chlamydia trachomatis infection in specimens obtained from 100 children with moderate-to-severe trachoma. The tests were Giemsa stain, isolation in cell culture, direct fluorescein-conjugated monoclonal antibody, enzyme immunoassay, and a DNA probe. The Giemsa stain was least sensitive at 29%. The other tests gave essentially equivalent performances: sensitivity ranged from 73% to 84% and specificity from 93% to 100%. Seven of the 45 positive specimens were only positive in cell culture, whereas 11 of the 45 were negative in culture but positive in at least two nonculture tests. We speculate that these discordant results actually reflect the biologic status of the chlamydial infection. There appears to be a stage in the infection where chlamydial antigens and nucleic acids can be detected in the absence of infectivity. This stage of infection may contribute to the pathogenesis of trachoma by providing a source of sensitizing antigen.
Holographic Optical Head For Compact Disk Applications (1989)

Considerations in using holographic optical elements and a laser/detector hybrid device for optical disk systems are discussed. The process for fabricating the holographic optical elements is briefly reviewed.
Visual resolution and spatial performance: the trade-off between resolution and interactivity (2002)

A series of experiments is reported in which subjects performed a search-and-act spatial task in conditions of reduced resolution and exploratory freedom. Images were produced using miniature cameras, comparing static camera position, passive camera movement, and head-coupled immersive VR/teleoperation conditions. By using cameras and real light, time lags could be avoided. Video processors were used to artificially reduce spatial, and temporal resolutions. Results show that although spatial and intensity resolutions are very important in static viewing conditions, like those of traditional image-producing computer graphics, subjects can complete the puzzle in head-mounted (VR-like) conditions with resolutions as little as 18/spl times/15 pixels. Furthermore results show that animation of the image viewpoint does not always improve spatial performance when the animation is not user-controlled; in some conditions performance actually got worse by adding passive movement.
Innovative Diagnostic and Treatment Options: An Interview with James R. Cowan, Jr., M.D., M.S., and Maryanne Cowan, L.C.S.W., Th.D. (2007)

It is not often that a successful psychiatrist and a social worker team up to use innovative diagnostics and treatments to help their patients, but James R. Cowan, M.D., M.S., and Maryanne Cowan, L.C.S.W., Th.D., are doing just that. What began 25 years ago as a professional association at East Orange General Hospital, (East Orange, New Jersey) has evolved into a marriage, a joint clinical practice, and an ongoing exploration of new technologies and therapies that blend allopathic and meridian-based protocols. Today, this team’s work is unique, successful, and quite unlike any other practice in the United States. Dr. James Cowan, a fourth-generation physician, has been a practicing psychiatrist in Northern New Jersey for 32 years. After graduating from Meharry Medical College (Nashville, Tennessee) in 1970, he completed his psychiatric training at Harlem Hospital and Columbia University Medical School (both in New York City). He also obtained a Master’s degree in community psychiatry from Columbia Medical School. As director of psychiatry at East Orange General Hospital for 27 years, he has built a comprehensive psychiatric program there. Dr. Maryanne Cowan received an L.C.S.W. degree from Rutgers (New Brunswick, New Jersey), and is a licensed clinical social worker. After receiving her degree, she was a social worker at East Orange General Hospital, and worked there for 3 years, and then established her own practice. This past March, she received a Doctor of Theology (Th.D. degree) in integrative health care and spiritual healing from the Holos Graduate Seminary in Fair Grove, Missouri. Dr. Maryanne Cowan has long been interested in complementary and alternative medicine (CAM), as well as in therapies that are nontoxic and noninvasive, and that have fewer side effects than allopathic treatments. It was she who sparked her husband’s interest in CAM protocols, and the team began to attend seminars on new diagnostic and treatment options to better serve their patients. This led to their creation of Advanced Dimensions in Healing, a complementary medicine and wellness center in Ridgewood, New Jersey. A variety of allopathic and CAM services are offered at the center, with such recent protocols as Gas Discharge Visualization (GDV) for real-time energy-field analysis; Bioresonance to provide healing at a cellular level; and SottoPelle,™ a form of bioidentical hormone replacement therapy.
Reduction of magnetic noise in PWM-supplied induction machines - low-noise design rules and multi-objective optimization: Reduction of electromagnetic audible acoustic noise and vibrations in electrical machines (2008)

This thesis focuses on the reduction of the audible magnetic noise radiated by induction machines due to air-gap radial Maxwell forces in variable-speed traction application (e.g. subways and light-rail vehicles). <br /><br />In a first part, an overview of the electrical and vibro-acoustic modelling techniques of induction machines and their associated assumptions is done. A review of the existing low magnetic noise design rules is done, and the influence of the motor and inverter design variables is discussed. Finally, the optimisation works applied to the induction machines are reported.<br /><br />In a second part, a fully analytical model of the vibro-acoustic and electrical behaviour of the induction machine is established. Some simulation results are validated with finite element or boundary element methods, or tests. Saturation, load and pulse-width modulation (PWM) effects are considered. <br /><br />In a third part, an exhaustive analytical description of the main magnetic forces is done. The exciting force harmonics are classified, and their characteristics are validated using experimental sonagrams and operational deflection shapes. On the ground on this analysis and DIVA simulations, some new low-noise design rules are inferred. <br /><br />The model is then coupled to an optimisation algorithm in order to design a new low-noise motor achieving specified traction characteristics. Two rotor prototypes are designed to decrease the noise of a given industrialised motor.<br /><br />Some tests are run on the first prototype, and up to a 15 dB decrease is observed in on-load PWM case. Furthermore, this new prototype successfully reached specified output torque without increasing iron losses neither phase current.
Nerve Growth Factor in Rat Glioma Cells (1974)

We have shown that rat glioma tumors contain a protein that crossreacts with antibody against mouse 2.5S nerve growth factor prepared in rabbit in microcomplement fixation assays and has analogous isoelectric points to all the hybrids of 2.5S nerve growth factor (a dimer). Partially purified protein preparations from gliomas cause chick dorsal root ganglia to extend neurites in the nerve growth factor assay and cause morphological differentiation of mouse neuroblastoma cells. We conclude that the rat glioma protein is homologous to mouse salivary nerve growth factor and suggest the possibility that glial nerve growth factor plays a role in neuronal development and regeneration.
Choline acetyltransferase inhibitors. Styrylpyridine analogs with nitrogen-atom modifications (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCholine acetyltransferase inhibitors. Styrylpyridine analogs with nitrogen-atom modificationsChester J. Cavallito, Hye Sook Yun, Michael Louis Edwards, and Francis F. FoldesCite this: J. Med. Chem. 1971, 14, 2, 130–133Publication Date (Print):February 1, 1971Publication History Published online1 May 2002Published inissue 1 February 1971https://pubs.acs.org/doi/10.1021/jm00284a011https://doi.org/10.1021/jm00284a011research-articleACS PublicationsRequest reuse permissionsArticle Views169Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The best clustering algorithms in data mining (2016)

In data mining, Clustering is the most popular, powerful and commonly used unsupervised learning technique. It is a way of locating similar data objects into clusters based on some similarity. Clustering algorithms can be categorized into seven groups, namely Hierarchical clustering algorithm, Density-based clustering algorithm, Partitioning clustering algorithm, Graph-based algorithm, Grid-based algorithm, Model-based clustering algorithm and Combinational clustering algorithm. These clustering algorithms give different result according to the conditions. Some clustering techniques are better for large data set and some gives good result for finding cluster with arbitrary shapes. This paper is planned to learn and relates various data mining clustering algorithms. Algorithms which are under exploration as follows: K-Means algorithm, K-Medoids, Distributed K-Means clustering algorithm, Hierarchical clustering algorithm, Grid-based Algorithm and Density based clustering algorithm. This paper compared all these clustering algorithms according to the many factors. After comparison of these clustering algorithms I describe that which clustering algorithms should be used in different conditions for getting the best result.