gebhart/patrepeval huggingface dataset:
Rarefaction of Skin Capillaries in Borderline Essential Hypertension Suggests an Early Structural Abnormality (1999)

We recently showed that rarefaction of skin capillaries in the dorsum of the fingers of patients with essential hypertension is due to the structural (anatomic) absence of capillaries rather than functional nonperfusion. It is not known whether this rarefaction is primary (ie, antedates the onset of hypertension) or secondary (ie, as a consequence of sustained and prolonged elevation of blood pressure [BP]). The aim of the present investigation was to study skin capillary density in a group of patients with mild borderline hypertension to assess whether rarefaction antedates the onset of sustained elevation of BP. The study group included 18 patients with mild borderline hypertension (mean supine BP, 136/83 mm Hg), 32 normotensive controls (mean BP, 126/77 mm Hg), and 45 patients with established essential hypertension (mean BP, 156/98 mm Hg). The skin of the dorsum of the fingers was examined by intravital capillary videomicroscopy before and after venous congestion at 60 mm Hg for 2 minutes. Patients with borderline essential hypertension had the lowest resting capillary density when compared with normotensive controls and patients with established hypertension. Maximal capillary density with venous congestion in the borderline group remained the lowest. The study confirmed that patients with borderline essential hypertension have skin capillary densities that are equally low as or even lower than patients with established hypertension. Both groups had significantly lower capillary densities than normal controls. One explanation for the results is that capillary rarefaction may be due to an early structural abnormality in essential hypertension.
Analysis of acid yield generated in chemically amplified electron beam resist (2006)

Acid-related matters are a critical issue in a chemically amplified resist, in which photo- or radiation (ionizing radiation)-generated acids drive pattern formation reactions in exposed areas. The photosensitization of resist materials has been formulated by Dill et al. [IEEE Trans. Electron. Dev. 22, 445 (1975)]. The applicability of the formulation by Dill et al. to acid generation in chemically amplified photoresists has been proven by many researchers. The acid yields in photoresists are predicted well by the formulation of Dill et al. However, the formulation of Dill et al. cannot be applied to chemically amplified resists for ionizing radiation such as electron beams and extreme ultraviolet rays because polymer ionization significantly contributes to acid generation in these resists. In this study, the authors formulated acid generation in a chemically amplified resist for ionizing radiation. By the analysis of the dependence of acid yield on acid generator concentration, the details of acid generation paths were clarified.
Polylactic acid: synthesis and biomedical applications (2019)

Social and economic development has driven considerable scientific and engineering efforts on the discovery, development and utilization of polymers. Polylactic acid (PLA) is one of the most promising biopolymers as it can be produced from nontoxic renewable feedstock. PLA has emerged as an important polymeric material for biomedical applications on account of its properties such as biocompatibility, biodegradability, mechanical strength and process ability. Lactic acid (LA) can be obtained by fermentation of sugars derived from renewable resources such as corn and sugarcane. PLA is thus an eco-friendly nontoxic polymer with features that permit use in the human body. Although PLA has a wide spectrum of applications, there are certain limitations such as slow degradation rate, hydrophobicity and low impact toughness associated with its use. Blending PLA with other polymers offers convenient options to improve associated properties or to generate novel PLA polymers/blends for target applications. A variety of PLA blends have been explored for various biomedical applications such as drug delivery, implants, sutures and tissue engineering. PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues due to their excellent biocompatibility and mechanical properties. The relationship between PLA material properties, manufacturing processes and development of products with desirable characteristics is described in this article. LA production, PLA synthesis and their applications in the biomedical field are also discussed.
Polymer Directed Self-Assembly of pH-Responsive Antioxidant Nanoparticles (2015)

We have developed pH-responsive, multifunctional nanoparticles based on encapsulation of an antioxidant, tannic acid (TA), using flash nanoprecipitation, a polymer directed self-assembly method. Formation of insoluble coordination complexes of tannic acid and iron during mixing drives nanoparticle assembly. Tuning the core material to polymer ratio, the size of the nanoparticles can be readily tuned between 50 and 265 nm. The resulting nanoparticle is pH-responsive, i.e., stable at pH 7.4 and soluble under acidic conditions due to the nature of the coordination complex. Further, the coordination complex can be coprecipitated with other hydrophobic materials such as therapeutics or imaging agents. For example, coprecipitation with a hydrophobic fluorescent dye creates fluorescent nanoparticles. In vitro, the nanoparticles have low cytotoxicity and show antioxidant activity. Therefore, these particles may facilitate intracellular delivery of antioxidants.
DNA Electrochemical Behaviors, Recognition and Sensing by Combining with PCR Technique (2003)

The electrochemical studies on the behaviors and recognition of DNA have attracted cosiderable attention. DNA biosensors based on a nucleic acid hybridization process are rapidly being developed towards the goal of rapid and inexpensive diagnosis of genetic andinfectious deseases. This brief review focuses on the current state of the DNA electrochemical sensors with emphasis on recent advances, challanges and trends. The works on DNA electrochemical behaviors, recognition and detection in our group in the last three years are also introduced.
HIV‐Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4<sup>+</sup>T Cells in Relation to HIV RNA Load (2004)

The average time between infection with human immunodeficiency virus (HIV) and development of acquired immune deficiency syndrome is approximately 8 years. However, progression rates vary widely, depending on several determinants, including HIV-specific immunity, host genetic factors, and virulence of the infecting strain. In untreated HIV-infected patients with different progression rates, we examined HIV-specific T cell responses in combination with host genetic markers, such as chemokine/chemokine-receptor (CCR) polymorphisms and human leukocyte antigen (HLA) genotypes. HIV-specific CD4(+) T cell responses and, to a lesser extent, HIV-specific CD8(+) T cell responses were inversely correlated with progression rate. Slower progression was not related to polymorphisms in CCR genes, HLA genotype, or GB virus C coinfection. These data suggest that HIV-specific T cell responses are involved in protecting the host from disease progression.
Design, Synthesis, and Biological Evaluation of New 5-HT<sub>4</sub> Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease (2009)

Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). However, despite the range of 5-HT(4)R agonists synthesized to date, potent and selective 5-HT(4)R agonists are still lacking. In the present study, two libraries of molecules based on the scaffold of ML10302, a highly specific and partial 5-HT(4)R agonist, were efficiently prepared by parallel supported synthesis and their binding affinities and agonist activities evaluated. Furthermore, we showed that, in vivo, the two best candidates exhibited neuroprotective activity by increasing the level of the soluble form of the amyloid precursor protein (sAPPalpha) in the cortex and hippocampus of mice. Interestingly, one of these compounds could also inhibit Abeta fibril formation in vitro.
Analytical model for a tunnel field-effect transistor (2008)

The tunnel field-effect transistor (TFET) is a promising candidate for the succession of the MOSFET at nanometer dimensions. Due to the absence of a simple analytical model for the TFET, the working principle is generally not well understood. In this paper a new TFET structure is introduced and using Kanepsilas model, an analytical expression for the current through the TFET is derived. Furthermore, a compact expression for the TFET current is derived and conclusions concerning TFET design are drawn. The obtained analytical expressions are compared with results from a 2D device simulator and good agreement at low gate voltages is demonstrated.
The Ethnic and Cultural Pluralism Award (1978)

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LOCKING OF He–Ne LASER MODES BY INTRACAVITY ACOUSTIC MODULATION IN COUPLED INTERFEROMETERS (1965)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. DiDomenico, V. Czarniewski; LOCKING OF He–Ne LASER MODES BY INTRACAVITY ACOUSTIC MODULATION IN COUPLED INTERFEROMETERS. Appl. Phys. Lett. 15 April 1965; 6 (8): 150–152. https://doi.org/10.1063/1.1754210 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle (1988)

Dietary intake of cholesterol has been linked to coronary heart disease. The effect of grapefruit pectin (Citrus paradisi) on plasma cholesterol, triglycerides, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and the low-density lipoprotein:high-density lipoprotein cholesterol ratio was studied. The study design was a 16-week double-blind, crossover (placebo or pectin) using 27 human volunteers screened to be at medium to high risk for coronary heart disease due to hypercholesterolemia. The study did not interfere with the subjects' current diet or lifestyle. Grapefruit pectin supplementation decreased plasma cholesterol 7.6%, low-density lipoprotein cholesterol 10.8%, and the low-density lipoprotein:high-density lipoprotein cholesterol ratio 9.8%. The other plasma lipid fractions studied showed no significant differences. We conclude that a grapefruit pectin-supplemented diet, without change in lifestyle, can significantly reduce plasma cholesterol.
Integrins in Kidney Disease (2013)

A major hallmark of chronic kidney injury is fibrosis, which is characterized by increased accumulation of extracellular matrix components that replace the damaged tissue. Normally, the synthesis and degradation of extracellular matrix components are finely regulated; however, when matrix replacement goes unchecked, there is unwanted and irreversible tissue scarring with consequent organ damage, organ failure, and, in certain cases, death. Many factors, including cell-matrix interactions, play a role in the development of renal fibrosis. Cell-matrix interactions are made possible by integrins, a family of transmembrane receptors that, upon binding to the extracellular matrix, activate intracellular signaling. Thus, they control various cell functions, including survival, proliferation, migration, and matrix homeostasis. Genetic mutations in humans and the development of animal models lacking integrins in selective parts of the kidney have improved our understanding of molecular mechanisms and pathways controlling matrix remodeling in kidney disease. Here we outline the major integrins involved in kidney disease and some of the major molecular mechanisms whereby integrins contribute to kidney fibrosis.
Complete Nucleotide Sequence of <i>Saccharomyces cerevisiae</i> Chromosome VIII (1994)

The complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII reveals that it contains 269 predicted or known genes (300 base pairs or larger). Fifty-nine of these genes (22 percent) were previously identified. Of the 210 novel genes, 65 are predicted to encode proteins that are similar to other proteins of known or predicted function. Sixteen genes appear to be relatively recently duplicated. On average, there is one gene approximately every 2 kilobases. Although the coding density and base composition across the chromosome are not uniform, no regular pattern of variation is apparent.
A simple and inexpensive culture device for cell growth, quantitative microscopy and autoradiography (1978)

SUMMARY An inexpensive culture chamber suitable for subsequent preparations for cyto‐chemical or radiographic work is demonstrated. The chamber consists of two glass microscope slides suitably prepared for cell growth and a gasket of silicone rubber. The slides and gasket are sealed and held together with two ordinary spring letter clips or clothes‐pins. Cells may be inoculated by piercing the gasket with a hypodermic needle, or by removing the top slide and adding cells directly. Long‐term cultivation with medium replacement is easy and efficient and addition of isotopes or other materials may be done aseptically.
AISI Direct Steelmaking Program. Annual technical report for year ending November 30, 1991 (1992)

The Direct Steelmaking Program has completed the third year of research and development since cost-share funding was provided by the Department of Energy. The physical chemistry programs conducted by Carnegie Mellon University (CMU) and the Massachusetts Institute of Technology (MIT) have been completed. A pilot plant has been constructed and successfully operated at Universal, Pennsylvania, and construction of a new, two-zone vessel pilot plant has been completed and trial operation is underway. The success of the pilot plant operation coupled with the development of process models involving reaction rates, heat-transfer and fluid-flow rates, and mass and energy balances has led to a basic study of a 350,000 tonne per year demonstration plant that gives promise of being a low capital and operating cost alternative for ironmaking as compared to the coke oven, blast furnace process. It has the further advantages of ease of startup and shutdown, lower energy consumption, and modularity so that capacity can be adapted to need. The physical chemistry programs at CMU and MIT studied fundamental reactions among ore, coal, flux, slag, metal droplets, and the liquid metal bath. Work at CMU centered on slag foaming studies, coal devolatilization, dissolution of hematite and wustite pellets in bath smelting slags, reduction of FeO in slag by char, extent of reverse or depostcombustion reactions in postcombustion gases, and developing an overall smelting model.
Stereoselectivity and generality of the palladium-catalysed cyclopropanation of α,β-unsaturated carboxylic acids derivatized with Oppolzer's sultam (1994)

A series of α,β-unsaturated carboxylic acids derivatized with camphorsultam 1 as a chiral auxiliary has been stereoselectively cyclopropanated. The selectivity of the reaction produces cyclopropanated products with the 1R, 2R absolute configuration as indicated by the optical rotations as well as by an X-ray structure determination. The temperature dependence of the reaction was studied with three substrates. The highest stereoselectivity was obtained at temperatures above 25 °C. Branching at the α- or β-carbons disfavours complete conversion, and electron-withdrawing substituents at these positions seem to prevent the reaction. The auxiliary was removed by using titanium(IV) isopropoxide in benzyl alcohol followed by alkaline hydrolysis of the intermediate ester. The potent 5-HT1A receptor agonist (1R,2S)-2-(2-hydroxyphenyl)-N,N-dipropylcyclopropylamine 13 was synthesized by this method.
A Conductive Additive for Positive Electrodes of Alkaline Batteries (2005)

For the first time, materials were synthesized at a very low temperature, below . The influence of synthesis parameters, such as temperature and time of reaction, on the structure and conductivity of the material was investigated. It was shown that these materials contain structural defects, such as stacking faults and lithium vacancies, which lead to a good electronic conductivity of these materials as compared to classical high-temperature materials. The time and temperature of reaction decrease the amounts of stacking faults in the materials. However, lithium intercalation can occur during a long-time synthesis, leading to a decrease in conductivity of the material. If process parameters are conveniently chosen, a material with a conductivity of around can be obtained and used with success as a conductive additive in positive electrodes of alkaline batteries. The major advantage of this new additive is that prevents the loss of capacity of alkaline cells at low voltage, in the whole potential window of the positive electrode in alkaline batteries.
A phase I study of 90Y-2IT-BAD-Lym-1 in patients with non-Hodgkin's lymphoma. (2001)

The safety and toxicity of 90Y-2IT-BAD-Lym-1 were determined and the MTD was 0.370 GBq/m2, a dose used in 4 patients. 90Y-2IT-BAD-Lym-1 may be useful for future clinical trials because 90Y is readily available and can deliver potent beta emissions to NHL. Bone marrow support however, will be required for further dose escalation.
DIGESTIBILITY OF PHYTIN PHOSPHORUS AND INTESTINAL PHYTASE IN DAIRY COWS AND SHEEP (1960)

The experiments described in the previous paper17) showed that the feeding of turnip roots or raw beet-tops produces a severe hypophosphataemia in dairy cows. In these cases, however, supplements of rice bran or wheat bran, which are concentrates containing phytin phosphorus in abundance, prevented the disorders caused by the hypophosphorosis. HARRISON et aI., HOFF-J0RGENSEN et ap,q,lO) and other authors 11,25) reported that phytic acid phosphorus is poorly utilized by animals; the feeding of concentrates containing phytate in abundance produces metabolic disorders of bone caused by the decrease of calcium retention, because the acid forms insoluble salts of calcium, magnesium, iron and other metals in the small intestine. On the contrary, FINGERLING, MATHUR, and TILLMAN and BRETHOUR have reported that phytic acid phosphorus is absorbed from the intestinal canal according to the dietary conditions in ruminants. The most reliable determination of the digestibility of phytin phosphorus can be obtained from dietary experinients with labelled phytate24) and from the
Oxidation of .alpha.-ketoacyl derivatives. Rearrangement of pyruvates to malonates (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation of .alpha.-ketoacyl derivatives. Rearrangement of pyruvates to malonatesMelvin L. Rueppel and Henry RapoportCite this: J. Am. Chem. Soc. 1972, 94, 11, 3877–3883Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 May 1972https://pubs.acs.org/doi/10.1021/ja00766a036https://doi.org/10.1021/ja00766a036research-articleACS PublicationsRequest reuse permissionsArticle Views578Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on Clot-induced Coagulation in Human Plasma (1998)

Recent studies have suggested that clot-bound thrombin plays an important role in thrombus growth. In this study, we examined the effects of recombinant human soluble thrombomodulin (rhsTM) on clot-induced coagulation. rhsTM enhanced the activation of protein C by clots, and attenuated clot-induced thrombin generation and fibrinopeptide A (FPA) production in a dose-dependent manner. The inhibitory effect of rhsTM was abolished by anti-protein C antibody. The inhibitory effect of rhsTM on clot-induced thrombin generation continued for over 60 min after the addition of the clot, while an active site-directed thrombin inhibitor, argatroban, produced a more transient inhibition. rhsTM also inhibited the regrowth of the clot in (125)I-fibrinogen-supplemented plasma. We also examined the effect of rhsTM by thromboelastography, rhsTM reduced the growth of the clot but had little effect on the time to begin clotting, while heparin and Fragmin (low molecular weight heparin) had effects opposite to those of rhsTM. These findings suggest that rhs-TM attenuates the growth of the clot by activating protein C and inhibiting further thrombin generation in the clot.