gebhart/patrepeval huggingface dataset:
Distribution of lymphocytes with interleukin-2 receptors (TAC antigens) in reactive lymphoproliferative processes, Hodgkin's disease, and non-Hodgkin's lymphomas. An immunohistologic study of 300 cases. (1987)

The authors investigated the distribution of interleukin-2 receptors (TAC antigen) in the lymph nodes of 300 patients with lymphoproliferative disorders. They used fresh-frozen sections to evaluate a possible correlation between the immunophenotype of specific lymphoid disorders and the presence or absence of TAC expression and to determine whether the TAC positivity of lymphoid cells contributes to the characterization of lymphoproliferative processes. All of the cases had previously been studied with a large screening panel of monoclonal antibodies and polyclonal antisera. Among 85 patients with a variety of benign reactive processes, the lymph nodes from 47 contained TAC-bearing lymphocytes in various patterns of distribution. Of 41 patients with Hodgkin's disease, 37 had TAC-bearing lymphocytes. Of 26 B-cell, well-differentiated lymphocytic lymphomas (WDL), 14 were diffusely TAC-positive and one had TAC-bearing cells in random distribution. Six cases of intermediate lymphocytic lymphoma were also studied, and three showed randomly distributed TAC-bearing lymphocytes. Of 19 patients with follicular or follicular and diffuse, poorly differentiated lymphocytic (PDL) lymphoma, 14 were TAC-positive. All 3 diffuse PDL lymphomas studied were TAC-negative. Among 23 cases of B-cell and 5 cases of T-cell mixed cell lymphoma, 15 and three, respectively, had TAC-positive lymphocytes. Of 39 large cell lymphomas (B-cell, 33; T-cell, 6), 14 were TAC-positive. All 13 cases of hairy cell leukemia were diffusely positive. Of 23 T-lymphoblastic lymphomas, only 1 showed positive TAC reactivity, which was focal. Of 5 cases of cutaneous T-cell lymphoma, 2 had TAC-bearing lymphocytes. Our study indicates that the TAC antigen is not lineage-specific, and that it may be expressed by lymphoid cells regardless of their phenotype.
Biopolyester Membranes of Plants: Cutin and Suberin (1980)

Cutin, a biopolyester composed of hydroxy and epoxy fatty acids, is the barrier between the aerial parts of higher plants and their environment. Suberin a polymer containing aromatics and polyesters, functions as a barrier in underground parts, wound surfaces, and a variety of internal organs. The composition and probable structure of these polymers are discussed. The biosynthesis of the hydroxy, epoxy, and dicarboxylic acids of the polyesters from the common cellular fatty acids is elucidated. An extracellular enzyme transfers the hydroxy and epoxyacyl moieties from their coenzyme A derivatives to the growing polyester. The enzymes acting in the biodegradation of the polyesters have been isolated from fungi, pollen, and mammals and characterized. The function and possible practical implications of these polyester barriers are briefly discussed.
One-Class SVM assisted accurate tracking (2012)

Recently, tracking is regarded as a binary classification problem by discriminative tracking methods. However, such binary classification may not fully handle the outliers, which may cause drifting. In this paper, we argue that tracking may be regarded as one-class problem, which avoids gathering limited negative samples for background description. Inspired by the fact the positive feature space generated by One-Class SVM is bounded by a closed sphere, we propose a novel tracking method utilizing One-Class SVMs that adopt HOG and 2 bit-BP as features, called One-Class SVM Tracker (OCST). Simultaneously an efficient initialization and online updating scheme is also\nproposed. Extensive experimental results prove that OCST outperforms some state-of-the-art discriminative tracking methods on providing accurate tracking and alleviating serious drifting.
Yoda1 analogue (<scp>D</scp>ooku1) which antagonizes <scp>Y</scp>oda1‐evoked activation of <scp>P</scp>iezo1 and aortic relaxation (2018)

Chemical antagonism of Yoda1-evoked Piezo1 channel activity is possible, and the existence of a specific chemical interaction site is suggested with distinct binding and efficacy domains.
In-situ stress state measurements during chip-on-board assembly (1999)

In this work, die stresses in wire bonded chip-on-board (COB) packages have been measured using special [111] silicon stress test chips. The test die incorporate an array of optimized eight-element dual polarity piezoresistive sensor rosettes, which are uniquely capable of evaluating the complete stress state (six stress components) at points on the surface of the die. Sensor resistance measurements were recorded before packaging, after die attachment, and throughout the encapsulant cure process. Using the appropriate theoretical equations, the stresses at sites on the die surface have been calculated from the raw sensor resistance data. Also, three-dimensional (3-D) nonlinear finite element simulations of the chip-on-board packages were performed, and the stress predictions were correlated with the experimental test chip data.
The effect of fluoride on succinic oxidase system (1952)

Although it has been known since the work of Battelli & Stern (1910) that the intracellular oxidation of succinate is inhibited by fluoride, the mechanism of this inhibition is little understood.
Monolithic, 3D-Printed Microfluidic Platform for Recapitulation of Dynamic Tumor Microenvironments (2018)

We report the development of an entirely 3D-printed, monolithic microfluidic platform that provides a dynamic microenvironment for perfusing and sustaining tumor fragments from a biopsy sample. The finely featured, noncytotoxic, and transparent tumor trap is integrated with threaded connectors for rapid, leak-proof fluid interfacing, an in-line trap for removal of bubbles arising from oxygenated media flow or tumor loading procedures, and a network of microchannels for supplying media (and potentially immune cells) to the trapped tumor fragment. The devices were additively manufactured in Pro3dure GR-10 -a relatively new, high-resolution stereolithographic resin with properties suitable for biomedical applications requiring interrogation via fluorescence microscopy. Overlaid bright-field and fluorescence microscopy images demonstrate trapping of human tumor fragments by the printed microfluidic device, as well as visualization of individual cells within the fragment. A multi-day trapping experiment evidences the ability to sustain a live tumor fragment under dynamic perfusion within the device-a configuration capable of modeling of interactions between tumors and various drug treatments in the presence of circulating immune cells, e.g., for assessment of the efficacy of chemotherapy and immunotherapy treatments.
Noninvasive evaluation of skeletal muscle mitochondrial capacity with near-infrared spectroscopy: correcting for blood volume changes (2012)

Near-infrared spectroscopy (NIRS) is a well-known method used to measure muscle oxygenation and hemodynamics in vivo. The application of arterial occlusions allows for the assessment of muscle oxygen consumption (mVo(2)) using NIRS. The aim of this study was to measure skeletal muscle mitochondrial capacity using blood volume-corrected NIRS signals that represent oxygenated hemoglobin/myoglobin (O(2)Hb) and deoxygenated hemoglobin/myoglobin (HHb). We also assessed the reliability and reproducibility of NIRS measurements of resting oxygen consumption and mitochondrial capacity. Twenty-four subjects, including four with chronic spinal cord injury, were tested using either the vastus lateralis or gastrocnemius muscles. Ten healthy, able-bodied subjects were tested on two occasions within a period of 7 days to assess the reliability and reproducibility. NIRS signals were corrected for blood volume changes using three different methods. Resting oxygen consumption had a mean coefficient of variation (CV) of 2.4% (range 1-32%). The recovery of oxygen consumption (mVo(2)) after electrical stimulation at 4 Hz was fit to an exponential curve, which represents mitochondrial capacity. The time constant for the recovery of mVo(2) was reproducible with a mean CV of 10% (range 1-22%) only when correcting for blood volume changes. We also examined the effects of adipose tissue thickness on measurements of mVo(2). We found the mVo(2) measurements using absolute units to be influenced by adipose tissue thickness (ATT), and this relationship was removed when an ischemic calibration was performed, supporting its use to compare mVo(2) between individuals of varying ATT. In conclusion, in vivo oxidative capacity can be assessed using blood volume-corrected NIRS signals with a high degree of reliability and reproducibility.
The recovery of anaerobic bacteria from swabs (1974)

When a standard sample of simulated exudate containing known numbers of anaerobic bacteria was taken up on a swab and plated on solid medium, the number of colonies subsequently cultured represented a very small proportion of the original sample. Evidence is produced that the apparent loss is not primarily attributable to inactivation on the swab but rather to retention of organisms on the swab. This was demonstrable with Clostridium welchii and with Bacteroides species that have hitherto been regarded as relatively oxygen-sensitive.When stock strains of Bacteroides species were held for some hours on swabs, some progressive loss of viability was demonstrable. A measure of protection was afforded when these organisms were held aerobically on blood agar medium, but a very exacting anaerobe and some wild strains of faecal anaerobes showed gradual inactivation under these conditions.These findings may have important implications in relation to currently employed bacteriological sampling procedures with swabs in clinical practice.
Exchange Coupling Assisted FePtC Perpendicular Recording Media (2008)

Magnetic hard and soft phases FePtC thin films based exchange coupling assisted (ECA) perpendicular recording media were prepared. The coercivity of the FePtC film decreased after introducing a top magnetic soft FePtC layer. The cross-sectional transmission electron microscopy image illustrated that the soft FePt grains were located both on top of the bottom FePt grains and the grain boundaries, where the hard and soft grains were separated by a C layer accumulated on the hard FePtC layer surface. The reduction of coercivity was attributed to the exchange coupling between FePt hard and soft grains. For hard and soft grains separated by the accumulated C layer, the strength of the exchange coupling depended on the carbon layer thickness.
Failed or inadequate bone marrow aspiration: a fast, simple and cost-effective method to produce a cell suspension from a core biopsy specimen (2005)

Failure to aspirate bone marrow (BM) diminishes diagnostic accuracy and efficiency because BM cell suspensions are crucial for modern haematological diagnostic methods such as cytomorphology, flow cytometric immunophenotyping (FCI), cytogenetics or fluorescent in situ hybridization (FISH). We mechanically disaggregated unfixed BM core biopsies with the Dako Medimachine in 65 cases of macroscopically suspected dry taps. Cytospins, three-colour FCI and in some cases karyotyping and FISH were performed successfully. Most cytospins (34 of 50; 68.0%) were of good quality, while a further 18.0% showed moderate but still informative quality. FCI showed good quality in 36 of 60 (60.0%) cases; in 13.3% quality was moderate, but diagnostically useful results were obtained. Surprisingly, all four cases of formerly undiagnosed BM-carcinosis could be clearly detected on cytospins. Finally, five of seven (71.4%) attempts yielded analysable metaphases mostly in cases where no metaphases could be obtained from BM or peripheral blood. The described method of mechanical disaggregation of unfixed BM core biopsies compares favourably with other published approaches, allowing the application of all techniques where BM cell suspensions are needed. Thus, it can help to establish the underlying diagnosis in patients with abnormalities in peripheral blood and unsuccessful marrow aspirations.
Superconductivity in Entirely End-Bonded Multiwalled Carbon Nanotubes (2006)

We report that entirely end-bonded multiwalled carbon nanotubes (MWNTs) can exhibit superconductivity with a transition temperature (T(c)) as high as 12 K, which is approximately 30 times greater than T(c) reported for ropes of single-walled nanotubes. We find that the emergence of this superconductivity is highly sensitive to the junction structures of the Au electrode/MWNTs. This reveals that only MWNTs with optimal numbers of electrically activated shells, which are realized by end bonding, can allow superconductivity due to intershell effects.
The ADP Receptor P2Y<sub>1</sub>is Necessary for Normal Thermal Sensitivity in Cutaneous Polymodal Nociceptors (2011)

These results strongly suggest that P2Y1 is required for normal thermal signaling in cutaneous sensory afferents. Furthermore, they suggest that nucleotides released from peripheral tissues play a critical role in the transduction of thermal stimuli in some fiber types.
On-line man-computer communication (1962)

On-line man-computer communication requires much development before men and computers can work together effectively in formulative thinking and intuitive problem solving. This paper examines some of the directions in which advances can be made and describes on-going programs that seek to improve man-machine interaction in teaching and learning, in planning and design, and in visualizing the internal processes of computers. The paper concludes with a brief discussion of basic problems involved in improving man-computer communication.
Relation Distillation Networks for Video Object Detection (2019)

It has been well recognized that modeling object-to-object relations would be helpful for object detection. Nevertheless, the problem is not trivial especially when exploring the interactions between objects to boost video object detectors. The difficulty originates from the aspect that reliable object relations in a video should depend on not only the objects in the present frame but also all the supportive objects extracted over a long range span of the video. In this paper, we introduce a new design to capture the interactions across the objects in spatio-temporal context. Specifically, we present Relation Distillation Networks (RDN) --- a new architecture that novelly aggregates and propagates object relation to augment object features for detection. Technically, object proposals are first generated via Region Proposal Networks (RPN). RDN then, on one hand, models object relation via multi-stage reasoning, and on the other, progressively distills relation through refining supportive object proposals with high objectness scores in a cascaded manner. The learnt relation verifies the efficacy on both improving object detection in each frame and box linking across frames. Extensive experiments are conducted on ImageNet VID dataset, and superior results are reported when comparing to state-of-the-art methods. More remarkably, our RDN achieves 81.8% and 83.2% mAP with ResNet-101 and ResNeXt-101, respectively. When further equipped with linking and rescoring, we obtain to-date the best reported mAP of 83.8% and 84.7%.
Hemolysis by diphenylsulfones: comparative effects of DDS and hydroxylamine-DDS. (1973)

Abstract A chemical derivative of 4,4′-diaminodiphenylsulfone (DDS) was found to produce methemoglobin in vitro. This drug, hydroxylamine-DDS (DDS-NHOH), also depleted glutathione (GSH) in human erythrocytes with decreased hexosemonophosphate shunt activity due to G6PD deficiency or incubation with galactose. GSH also fell in rat red blood cells incubated with galactose and DDS-NHOH, and the 51 Cr survival of these treated erythrocytes was decreased as compared to appropriate controls. DDS-NHOH inhibited catalase in the presence of aminotriazole, suggesting that intracellular hydrogen peroxide was generated. DDS had none of these effects. These results indicated that this chemical derivative of DDS may be responsible for some of the known side-effects of this antimalarial and antileprosy drug.
InterRett and RettBASE: International Rett Syndrome Association Databases for Rett Syndrome (2003)

In 2001, the International Rett Syndrome Association funded the establishment of a World Wide Web-based database to collect and display the genetic data of children and adults with Rett syndrome from around the world. RettBASE (<http://mecp2.chw.edu.au>) encompasses both published and unpublished data; includes pathogenic mutations, benign polymorphisms, and sequence variations of uncertain significance; and has a range of query capabilities, allowing for simple or complex interrogation of the database. To undertake genotype-phenotype correlations and to identify the likely subtle differences in phenotype, detailed phenotype data on large samples will be provided by the International Rett Syndrome Association International Phenotype database InterRett. InterRett is under development by the Australian Rett syndrome study group at the Telethon Institute for Child Health Research in Perth, Western Australia. It will collect data from clinicians and families and provide deidentified, collated data on the Internet (<http://www.ichr.uwa.edu.au/rett/irsa>). Data records will be linked with RettBASE through a common unique identifier. An international reference panel is advising on the development of the database. Data collection procedures from families and clinicians are currently being piloted. Full data collection from both groups began in the second half of 2003. Concurrently, the output database will be developed to provide deidentified individual records and collated data for clinicians and researchers and collated data for families and the general public. This Web-based database will be an invaluable resource for understanding the nature of the disorder and managing children and adults with Rett syndrome.
Energy for China (2002)

Rarely has the world witnessed the breathtaking economic developments currently ongoing in China. Neither the explosive entry in the international scene by the fresh nation of the United States, following World War Ⅰ, nor the reconstruction frenzy of post-World War Ⅱ Europe and Japan can rival the growth of China in the last decade and the even more intense one expected in the future.
S-100 Serum Levels after Minor and Major Head Injury (1998)

S-100 appears to be a promising marker for the severity of head injury and neuronal damage.
Vapour Phase Oxidation of 4-pyridinemethanol to 4-pyridine carboxaldehyde (1990)

Abstract A versatile and useful preparation of 4-pyridine carboxaldehyde, an important pharmaceutical intermediate, by vapour phase mode of oxidation of 4-pyridinemethanol over V-Mo-O catalyst is developed for the first time. The probable mechanism and experimental procedure are reported.
Rheological Screening of Low-Molecular-Weight Polyacrylamide/Chromium(III) Acetate Water Shutoff Gels (2000)

Abstract Low-molecular-weight polyacrylamides crosslinked with chromium(III) acetate are widely used in the oilfield industry to seal off watered out zones in matricial reservoirs. These products are usually mixed in surface facilities, then pumped downhole through coiled tubing and injected into the formation over a depth of several feet. For the operators, gelation time and gel consistency after well shut-in are the two most important parameters to control. The pumping time cannot exceed the gelation time and the maximum pressure drawdown sustainable by the gel is related to gel consistency (as measured, for instance, by the yield stress). Both are known to depend on temperature, polymer concentration and structure (molecular weight, hydrolysis degree), and crosslinker concentration. A systematic screening of these parameters has been undertaken by means of rheological measurements using a cone-and-plate rheometer. The procedure for determining gelation time consisted in monitoring the viscosity of the polymer and crosslinker solutions mixed at time t=0 and then submitted to shearing at a constant rate. The gelation time, which corresponds to a sudden rise in the viscosity, was observed to be independent of the applied shear rate but to strongly vary with temperature and, to a lesser extent, with polymer hydrolysis degree, concentration and molecular weight and crosslinker concentration. From the set of data obtained, simple correlations or rules of thumb for the gelation time variations are given, which can be used to optimize the formulation for a given field application. To evaluate gel consistency, some yield stress measurements were performed after a resting (shut-in) time of about 10 hours. The yield stress is related to the maximum drawdown sustainable by the gel in a formation through a simple relationship.
A Real-Time Magnetoencephalography Brain-Computer Interface Using Interactive 3D Visualization and the Hadoop Ecosystem (2015)

Ecumenically, the fastest growing segment of Big Data is human biology-related data and the annual data creation is on the order of zetabytes. The implications are global across industries, of which the treatment of brain related illnesses and trauma could see the most significant and immediate effects. The next generation of health care IT and sensory devices are acquiring and storing massive amounts of patient related data. An innovative Brain-Computer Interface (BCI) for interactive 3D visualization is presented utilizing the Hadoop Ecosystem for data analysis and storage. The BCI is an implementation of Bayesian factor analysis algorithms that can distinguish distinct thought actions using magneto encephalographic (MEG) brain signals. We have collected data on five subjects yielding 90% positive performance in MEG mid- and post-movement activity. We describe a driver that substitutes the actions of the BCI as mouse button presses for real-time use in visual simulations. This process has been added into a flight visualization demonstration. By thinking left or right, the user experiences the aircraft turning in the chosen direction. The driver components of the BCI can be compiled into any software and substitute a user's intent for specific keyboard strikes or mouse button presses. The BCI's data analytics OPEN ACCESS Brain. Sci. 2015, 5 420 of a subject's MEG brainwaves and flight visualization performance are stored and analyzed using the Hadoop Ecosystem as a quick retrieval data warehouse.
Formación de posgrado en psicología clínica: una perspectiva europea (1990)

We analysed how replacing cereal concentrates with dehydrated orange pulp (DOP) in the diet of mother goats affects the meat quality of suckling kids. Three experimental diets for mother goats were designed. The DOP-0 diet contained commercial concentrates and alfalfa hay. In the DOP-40 and DOP-80 diets, 40% and 80% (respectively) of the cereal in the concentrate was replaced with pellets of DOP (the alfalfa hay component was unchanged). We evaluated the chemical composition, texture, water holding capacity, colour, fatty acids (FAs) profile, volatile compounds, and sensorial appraisal of the meat from 30 male suckling kids (cold carcass weight 4.74 kg, 4.82 kg, and 4.65 kg for DOP-0, DOP-40, and DOP-80, respectively) of the Payoya breed (n = 10 for each diet). Meat from kids in the DOP-40 and DOP-80 groups exhibited characteristics favourable for human health, including the meat's thrombogenicity index, PUFA/SFA ratio (0.60 index), and n-6 PUFA/n-3 PUFA ratio (approximately 7.50). The meat also exhibited reduced MUFA content (around 460 mg/100 g fresh meat). An increase in ethyl furan, dimethyl disulphide and heptane was observed in grilled meat from goats that were fed using DOP. The inclusion of DOP in goat feed improved consumers' sensory appreciation of the kid's meat.