gebhart/patrepeval huggingface dataset:
Multi-platform user interface construction (2006)

The popular view of software engineering focuses on managing teams of people to produce large systems. This paper addresses a different angle of software engineering, that of development for re-use and portability. We consider how an essential part of most software products - the user interface - can be successfully engineered so that it can be portable across multiple platforms and on multiple devices. Our research has identified the structure of the problem domain, and we have filled in some of the answers. We investigate promising solutions from the model-driven frameworks of the 1990s, to modern XML-based specification notations (Views, XUL, XIML, XAML), multi-platform toolkits (Qt and Gtk), and our new work, Mirrors which pioneers reflective libraries. The methodology on which Views and Mirrors is based enables existing GUI libraries to be transported to new operating systems. The paper also identifies cross-cutting challenges related to education, standardization and the impact of mobile and tangible devices on the future design of UIs. This paper seeks to position user interface construction as an important challenge in software engineering, worthy of ongoing research.
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia (2011)

MIM/MTSS1 is a tissue-specific regulator of plasma membrane dynamics, whose altered expression levels have been linked to cancer metastasis. MIM deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. Here, we generated MIM mutant mice and found that full-length MIM protein is dispensable for embryonic development. However, MIM-deficient mice displayed a severe urinary concentration defect caused by compromised integrity of kidney epithelia intercellular junctions, which led to bone abnormalities and end-stage renal failure. In cultured kidney epithelial (MDCK) cells, MIM displayed dynamic localization to adherens junctions, where it promoted Arp2/3-mediated actin filament assembly. This activity was dependent on the ability of MIM to interact with both membranes and actin monomers. Furthermore, results from the mouse model and cell culture experiments suggest that full-length MIM is not crucial for Shh signaling, at least during embryogenesis. Collectively, these data demonstrate that MIM modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia.
A comparative study of electricity price variations with wind energy penetration (2015)

This paper aims to compare the effect of wind energy penetration on electricity prices by considering different levels of installed wind capacities. The market clearing problem is formulated as a two stage stochastic optimization problem, where the first stage represents the clearing of the market with scheduled wind production and the second stage models the balancing market operations with different possible wind energy scenarios. A comparison is made between the size of the system and the price variations by taking three different test systems.
A perceptually lossless, model-based, texture compression technique (2000)

In natural scenes, still images as well as sequences, backgrounds, and objects' surfaces usually have a textural structure. Therefore, in order to efficiently code images it is crucial to investigate the texture compression problem. In this paper, a perceptually lossless, synthesis-by-analysis texture coding method is presented. The proposed approach is model based; the parameters of the model consist of a binary excitation signal and the parsimonious representation of the reconstruction filter. The estimated parameters, which allow to one synthesize, at the decoder site, a texture that is perceptually indistinguishable from the original one, are then compressed using a lossless strategy, which is based on a fast binary wavelet transformation specifically tailored to binary images. The proposed method leads to very good perceptual results superior to those of existing techniques.
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells (2002)

Similar to its role in secretory cells, calcium triggers exocytosis in nonsecretory cells. This calcium-dependent exocytosis is essential for repair of membrane ruptures. Using total internal reflection fluorescence microscopy, we observed that many organelles implicated in this process, including ER, post-Golgi vesicles, late endosomes, early endosomes, and lysosomes, were within 100 nm of the plasma membrane (in the evanescent field). However, an increase in cytosolic calcium led to exocytosis of only the lysosomes. The lysosomes that fused were predominantly predocked at the plasma membrane, indicating that calcium is primarily responsible for fusion and not recruitment of lysosomes to the cell surface.
Automated design evaluation on layout of Piping and Instrumentation Diagram using Histogram of Connectivity (2016)

An autonomous framework to evaluate layout of a Piping and Instrumentation Diagram (also known as P&ID or piping design) according to a set of standards of marine and offshore industry is proposed. The method starts with transforming layout of a P&ID into a vector x in R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">d</sup> . Transformation is done based on a novel concept developed for piping design known as Histogram of Connectivity (HoC). The proposed descriptor captures two essential properties of piping design: attributes of each component and connectivity among the components. Next, linear Support Vector Machine (SVM) is used to learn from existing compliant and non-compliant designs. Subsequently, the linear classifier can be used to check if an unseen design complies with the standards, hence achieving the aim of checking compliance of layout of a piping design. The method has demonstrated state of the art performance in a challenging dataset of designs created with advices from experienced engineers in marine and offshore industry, based on International Convention for the Prevention of Pollution from Ships (MARPOL).
Randomized controlled pilot trial of naloxone-on-release to prevent post-prison opioid overdose deaths (2016)

Large randomized trials are feasible with prison populations. Provision of take-home emergency naloxone prior to prison release may be a life-saving interim measure to prevent heroin overdose deaths among ex-prisoners and the wider population.
Why is my internet slow? (2011)

With widespread broadband adoption, more households report experiencing sub-optimal speeds. Not only are slow speeds frustrating, they may indicate consumers are not receiving the services they are paying for from their internet service providers. Yet, determining the speed and source of slow-downs is difficult because few tools exist for broadband management. We report on results of a field trial with 10 households using a visual network probe designed to address these problems. We describe the results of the study and provide design implications for future tools. More importantly, we argue that tools like this can educate and empower consumers by making broadband speeds and sources of slow-downs more visible.
Particle velocity fluctuations and correlation lengths in dilute sedimenting suspensions (2002)

We measure the instantaneous velocity of particles sedimenting in a three-dimensional container at low particulate Reynolds numbers. We aim at characterizing the main specificities of the particle velocity fluctuations. We obtain the local and instantaneous Eulerian velocity field from particle image velocimetry: a thin Yag laser light sheet (about two diameters thick) illuminates the particles from one side of the cell to the other. Our measurements are therefore spatially localized and, together with the squared cross sections of the cells, these are the two main originalities of our instrumentation. Four different cells and three different particle sizes give access to aspect ratios (cell width W over particle radius a) ranging from about 50 up to 800. We confirm the existence of eddy-like structures for the velocity fluctuations. The structure size is found to be almost independent of the volume fraction Φ for 6.25×10−4&lt;Φ&lt;5×10−2 for a fixed aspect ratio W/a, in seeming contradiction with the results of Segrè et al. [Phys. Rev. Lett. 79, 2574 (1997)]. The velocity fluctuations’ profiles are close to parabolic for the smallest aspect ratios but display a plateau value in the central part of the cell for higher aspect ratios. The unexpected result of our experiments is the large distance of influence of the boundaries: in fact, the plateau values are observed to saturate for aspect ratios larger than a few hundreds for Φ=1×10−2, for example. Moreover, the saturated plateau values scale as φ0.45±0.05, in contrast with the φ1/3 scaling observed in most previous works.
Effects of antihypertensive agents on endothelium‐dependent and endothelium‐independent relaxations. (1989)

1. Antihypertensive agents normalize blood pressure and restore depressed endothelium-dependent relaxations in experimental models of hypertension, but little is known regarding whether antihypertensive agents themselves can directly modulate responses to agonists of endothelium-dependent or independent relaxations, or contractions. 2. Normal rats were treated with either tap water, captopril, hydralazine or enalapril in their drinking water for 2 weeks, following which endothelium-dependent and endothelium-independent relaxations were tested with acetylcholine and sodium nitroprusside, respectively, in aortic rings suspended in organ chambers. 3. All antihypertensive agents caused slight but similar potentiation of sodium nitroprusside-induced relaxations. However, their effects on acetylcholine-induced relaxations were quite different: captopril had a marked potentiating effect, hydrazaline a slight potentiating effect, and enalapril had no significant effect on these relaxations. 4. The relaxations induced by acetylcholine and potentiated by captopril were not altered when indomethacin was included in the tissue bath. However, pyrogallol, an inhibitor of endothelium-derived relaxing factor (EDRF), markedly inhibited these relaxations suggesting that captopril's effect may involve EDRF. 5. SQ 14,534, a stereoisomer of captopril which is 100 fold less potent in inhibiting angiotensin converting enzyme, also significantly enhanced acetylcholine induced relaxations. Thus the effects of both captopril and SQ 14,534 upon EDRF appear independent of the effects of these compounds on the angiotensin converting enzyme. 6. We conclude that certain antihypertensive agents may modulate endothelium-dependent relaxations in response to agonists, and that these properties may be of therapeutic importance in cardiovascular diseases.
A high-speed built-in-self-test design for DRAMs (2003)

A high-speed Built-In Self-Test (BIST) design for Dynamic Random Access Memories (DRAMs) is proposed. The circuit automatically generates a sequence of pre-defined test patterns for on-chip DRAM testing. The innovation herein is mainly an architecture consisting of two finite state machines, instead of the conventional single finite state machine. Based upon this novel architecture, the pipeline technique can then be applied to divide the pattern generation process into stages, leading to a higher-speed design. In addition to pipelining, a technique referred to as protocol-based relaxation is also incorporated. This technique, imposing a certain protocol on the two communicating finite state machines, further relaxes the timing criticality of the design. Synthesis results show that the proposed BIST circuit can operate at the speed of as high as 400 MHz using 0.35 um CMOS technology.
Association of olfactory dysfunction with incidental Lewy bodies (2006)

Olfactory dysfunction is found in early Parkinson's disease (PD) and in asymptomatic relatives of PD patients. Incidental Lewy bodies (ILB), the presence of Lewy bodies in the brains of deceased individuals without a history of PD or dementia during life, are thought to represent a presymptomatic stage of PD. If olfactory dysfunction were associated with the presence of ILB, this would suggest that olfactory deficits may precede clinical PD. The purpose of this study was to determine the association of olfactory dysfunction during late life with ILB in the substantia nigra or locus ceruleus. Olfaction was assessed during the 1991-1994 and 1994-1996 examinations of elderly Japanese-American men participating in the longitudinal Honolulu-Asia Aging Study. Among those who later died and underwent a standardized postmortem examination, brains were examined for Lewy bodies in the substantia nigra and the locus ceruleus with hematoxylin and eosin stain. Lewy bodies in the brains of individuals without clinical PD or dementia were classified as ILB. There were 164 autopsied men without clinical PD or dementia who had olfaction testing during one of the examinations. Seventeen had ILB. The age-adjusted percent of brains with ILB increased from 1.8% in the highest tertile of odor identification to 11.9% in the mid-tertile to 17.4% in the lowest tertile (P = 0.019 in test for trend). Age-adjusted relative odds of ILB for the lowest versus the highest tertile was 11.0 (P = 0.02). Olfactory dysfunction is associated with ILB. If incidental Lewy bodies represent presymptomatic stage of PD, olfactory testing may be a useful screening tool to identify those at high risk for developing PD.
Hyperspectral image analysis techniques for the detection and classification of the early onset of plant disease and stress (2017)

This review explores how imaging techniques are being developed with a focus on deployment for crop monitoring methods. Imaging applications are discussed in relation to both field and glasshouse-based plants, and techniques are sectioned into 'healthy and diseased plant classification' with an emphasis on classification accuracy, early detection of stress, and disease severity. A central focus of the review is the use of hyperspectral imaging and how this is being utilised to find additional information about plant health, and the ability to predict onset of disease. A summary of techniques used to detect biotic and abiotic stress in plants is presented, including the level of accuracy associated with each method.
Cultivation of the Paddy Straw Mushroom, Volvariella volvacea (Bull, ex Fr.) Sing.1 (1972)

Abstract The paddy straw mushroom was grown on the type of compost commonly used to produce the cultivated mushroom, Agaricus bisporus (Lange) Sing. An appreciable quantity of light (15 min full sunlight) is required for initiation of fruit bodies. The average yield of paddy straw mushroom was 84 g mushrooms fresh wt/kg dry wt of compost at spawning time. Such production is in the range reported for straw mushroom production on rice straw in Asia but only 20% of the yield of the cultivated mushroom or champignon, A. bisporus .
Notes on books (1873)

Notes on books Get access Edward Peacock Edward Peacock 1Bottesford Manor, Brigg. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s4-XII, Issue 298, 13 September 1873, Pages 219–220, https://doi.org/10.1093/nq/s4-XII.298.219f Published: 13 September 1873
Comparison of analysis techniques for the dynamic behaviour of an integrated drivetrain in a wind turbine (2002)

In recent years wind energy has been the world's fastest growing source of energy. The wind turbine industry is booming and is spending a lot on research for improving the performance of its present machines and increasing their capacity. However, upscaling of the classical drivetrain concept is no longer economically feasible for machine power of 2 MW and higher. This paper presents the preliminary results of dynamic studies on a new design concept for the drivetrain of a multi megawatt wind turbine. At first, a rather coarse finite element model is used to analyse the dynamic behaviour of the entire system. Then, a more detailed multibody model of the drivetrain is built for the analysis of torsional vibrations. Eigenmodes and eigenfrequencies obtained in this analysis using two different software packages are compared.
Phase Transition of Contact-Electrified Negative Charges on a Thin Silicon Oxide in Air (1996)

We investigated the dense contact-electrified negative charges on a thin silicon oxide surface by the reproducible and controllable contact electrification technique using an atomic force microscope (AFM). Time evolution of the contact-electrified negative charges, which was observed as electrostatic force, showed three dissipation processes. First, the contact-electrified negative charges dissipate slowly, then rapidly and finally, slowly again. It was found by comparison between attractive and repulsive force measurements that the first dissipation process was stable for the applied electric field, whereas the second one was unstable. Analysis of contact voltage dependence and time evolution of the spatial integral of the contact-electrified negative charges revealed the charge sites of silicon oxide for the negative charge. Furthermore, it was found that the time evolution from the first stable dissipation process to the second unstable one was a phase transition from a solid phase to a liquid or gas phase of the contact-electrified negative charges, which was investigated in terms of the nondimensional parameter Γ. By comparison between the spatial distributions of the electrostatic forces measured repulsively and attractively, it was found that the contact-electrified negative charges were very dense and stable in the central region (i.e., solid phase), whereas they were sparse and unstable in the surrounding region (i.e., liquid or gas phase).
Characterization of β-Lactamase Enzyme Activity in Bacterial Lysates using MALDI-Mass Spectrometry (2011)

Plasmid-encoded β-lactamases are a major reason for antibiotic resistance in gram negative bacteria. These enzymes hydrolyze the β-lactam ring structure of certain β-lactam antibiotics, consequently leading to their inactivation. The clinical situation demands for specific first-line antibiotic therapy combined with a quick identification of bacterial strains and their antimicrobial susceptibility. Strategies for the identification of β-lactamase activity are often cumbersome and usually lack sensitivity and specificity. The current work demonstrates that matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an ideal tool for these analytical investigations. Herein, we describe a fast and specific assay to determine β-lactamase activity in bacterial lysates. The feasibility of the analytical read-out was demonstrated on a MALDI-triple quadrupole (QqQ) and a MALDI time-of-flight (TOF) instrument, and the results allow the comparison of both approaches. The assay specifically measures enzyme-mediated, time-dependent hydrolysis of the β-lactam ring structure of penicillin G and ampicillin and inhibition of hydrolysis by clavulanic acid for clavulanic acid susceptible β-lactamases. The assay is reproducible and builds the basis for future in-depth investigations of β-lactamase activity in various bacterial strains by mass spectrometry.
A Proposed Experiment in Automated Serials Accessioning (1971)

Loughborough University of Technology Library is exploring the possibility of automating accessions as part of the collaboration with BLCMP (Birmingham Libraries Co‐operative Mechanisation Project) on MASS (MARC‐based Automated Serials System). The automation of serials accessions was specifically excluded from the work reported in references 1 and 2 in order to allow time for the study of existing systems and arrive at new proposals. Until recently, the exploration has been purely theoretical, but a proposal for practical experimentation has now been formulated.
Hunger in Humans Induced by 2-Deoxy-D-Glucose: Glucoprivic Control of Taste Preference and Food Intake (1977)

Intracellular glucopenia induced by 2-deoxy-D-glucose (2DG) administration in man produces increased hunger ratings and magnitude estimates of pleasantness for sucrose solutions. Augmented food intake substantiates these changes in affective behavior and relieves experimentally induced hunger. Intracellular glucopenia activates counterregulatory mechanisms to raise plasma glucose concentrations. Inducing hunger experimentally with 2DG provides a useful method for studying appetitive behavior in humans. The neurohumoral control of pituitary hormone release and other hypothalamic functions may be examined after 2DG infusion.
Ultrastructural alterations in hippocampal mossy fiber synapses in schizophrenia: A postmortem morphometric study (2005)

Synapses formed between mossy fibers, the axons of hippocampal dentate granular cells, and the dendrites of CA3 pyramidal neurons are important links within the trisynaptic circuitry. Abnormalities in this circuitry are associated with the failure of schizophrenics to integrate affective experience with higher cognitive function, and with disturbances in memory and spatial learning processes. The abnormalities include reduced size and altered dendritic arborization of CA3 pyramidal neurons. In addition, decreased expression and binding activity of glutamate receptors have been reported, predominantly in the CA3 region of the hippocampus. These findings suggest that there are disturbed neuronal processes and connections in the hippocampus of schizophrenics. An electron microscope morphometric study of synaptic contacts between mossy fiber axon terminals (MFT) and branched dendritic spines of pyramidal neurons in stratum lucidum of the CA3 region of the hippocampus was performed in 10 normal controls and 9 age-matched chronic schizophrenics (postmortem delay 3-9 h). Schizophrenic cases with predominantly positive symptoms had a significantly reduced volume fraction of spines (-35%, P < 0.05), total number of invaginated spines (-47%, P < 0.01), and number of spines forming synapses (-32%, P < 0.05) per MFT compared with the control group. No effects of postmortem delay, age, duration of disease, or neuroleptic exposure were found. These data may reflect decreased efficacy of mossy fiber synapses in the CA3 hippocampal region in schizophrenics with predominantly positive symptoms. These data are in line with the neurodevelopmental hypothesis of schizophrenia.
Measuring Support for Organizational Innovation: A Validity Study (1990)

A 30-item version of the Perceived Support for Innovation scale was completed by 30 employees from an engineering firm judged to be ‘innovative’ by local businesspersons and 30 from a similar firm judged to be ‘noninnovative’ by these persons. Employees from the innovative firm obtained significantly higher mean scores than those from the noninnovative firm on each of the five subscales. Factor analysis of the responses of the two groups of employees both yielded a single general factor, rather than the five separate factors posited by the scale developers. Significant positive relationships were found between the scores on Perceived Support for Innovation and, respectively, job satisfaction, work motivation, and job involvement. These results are interpreted as providing some support for the validity of the inventory, beyond the school setting in which it was developed.