gebhart/patrepeval huggingface dataset:
STRUCTURE AND ACTIVITY RELATIONSHIP OF MONOAMINE OXIDASE INHIBITORS, PHENYLACETYLHYDRAZIDE DERIVATIVES (1963)

Since the introduction of iproniazid, originally synthesized as antitubercular drug, monoamine oxidase (MAO) inhibitors have been applied to the treatment of mental depression and angina pectoris. Most of the MAO inhibitors are chemically hydrazine and hydrazide derivatives. It is suggested by many investigators that pharmacological effects of the inhibitors derive from accumulation of serotonin and catecholamines in the central nervous system and other organs. The socalled side effects of the inhibitors such as liver damage are supposed to be due to unknown direct effects. Efforts to find out less toxic inhibitors have been done, thereupon. The present paper describes the structure-activity relationship of new MAO inhibitors, phenylacetylhydrazide derivatives by use of iproniazid and phenylisopropylhydrazine (JB-516) as control. The chemical structures of the derivatives are shown in Fig. 1.
Bond fixation in annulenes. 12. Effect of vicinal di-tert-butyl substitution on cyclooctatetraene valence isomerization. 7,8-Di-tert-butylbicyclo[4.2.0]octa-2,4,7-triene (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBond fixation in annulenes. 12. Effect of vicinal di-tert-butyl substitution on cyclooctatetraene valence isomerization. 7,8-Di-tert-butylbicyclo[4.2.0]octa-2,4,7-trieneYuji Hanzawa and Leo A. PaquetteCite this: J. Am. Chem. Soc. 1981, 103, 9, 2269–2272Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/ja00399a022https://doi.org/10.1021/ja00399a022research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer (2009)

Selective epigenetic disruption of distinct biological pathways was observed during development of platinum resistance in ovarian cancer. Integrated analysis of DNA methylation and gene expression may allow for the identification of new therapeutic targets and/or biomarkers prognostic of disease response. Finally, our results suggest that epigenetic therapies may facilitate the prevention or reversal of transcriptional repression responsible for chemoresistance and the restoration of sensitivity to platinum-based chemotherapeutics.
Factors regulating the concentrations of 16-androstene steroids in submaxillary salivary glands of pigs. (1996)

The measurement of 16-androstene steroids in submaxillary salivary glands is a potentially good way to estimate boar taint. The objective of this work was to identify factors regulating the concentrations of these steroids in salivary glands. Large White x Pietrain male pigs were divided into four treatments: T-1, intact untreated (n = 18); T-2, intact treated with porcine somatotropin (pST, n = 18); T-3, intact immunized against LHRH (n = 20); and T-4, castrated untreated (n = 19). The pigs were slaughtered at 105 mg of live weight. The mean concentrations of the compounds measured after slaughter for T-1 were as follows: 16-androstene steroid binding protein (pheromaxein) in salivary glands, 2.08 +/- .19 micrograms/g; 16-androstene steroids in salivary glands, 43.3 +/- 2.9 micrograms/g; androstenone in fat, .67 +/- .07 micrograms/g. In all other treatments, the concentrations were reduced (P = .001); T-2 and T-3 had intermediate and T-4 had the least concentrations of the measured compounds. The reduction of 16-androstenes in salivary glands was less than androstenone in fat, probably due to pheromaxein. The overall correlation between androstenone and 16-androstenes was r = .602 (P < .001) and for T-1 was r = .613 (P < .001). The overall correlation between pheromaxein and 16-androstenes was r = .777 (P < .001) and r = .928 (P < .001) for T-1. Only in T-3 was the estimation of the relationship between androstenone and 16-androstenes improved by measuring pheromaxein. These results indicate that pheromaxein is more closely related to the concentration of 16-androstene steroids in salivary glands than in fat. Synthesis of pheromaxein is dependent on mature, functional testes. We conclude that boar taint can be estimated by measuring the concentrations of 16-androstene steroids in salivary glands.
Intake Policies and Procedures at Eighteen Homes for the Aged and Inquirers and Applicants at Four Homes (1951)

This is the report of an inquiry undertaken between September, 1949, and March, 1950, by eighteen homes for the aged in chicago, the Community Project for the Aged of the Welfare Council of Metropolitan Chicago, and a research seminar at the School of Social Service Administration of the University of Chicago. The report is written by one of the participating faculty members; most of the work, however, was performed by others. Board and staff members of the homes devoted much time to providing the necessary facts. The staff of the Community Projects for the Aged encouraged the making of the inquiry, provided counsel at all times and some of the footwork in getting the task under way. Miss Mary Zahrobsky, of the faculty shared responsibility throughout the inquiry, from the day it appeared as a potential research experience for students in social work. The students used both their brains and their brawn in the collecting and processing of data, and from their manuscripts the writer has drawn liberally for this presentation.
High efficiency DC-DC converter (2002)

A family of power converter topologies employing two complementary switches in the primary and two MOSFET synchronous rectifiers in the secondary is presented. The use of two complementary switches in the primary leads to soft transitions across the switching elements, and the complementary square waveforms reflected in the secondary offers a simple and efficient driving waveform for the synchronous rectifiers. Employing one of these topological configurations, a very high efficiency and high power density 150 W converter was implemented. The power converter operates from an input voltage of 35 V to 72 V providing 5 V at 30 A, with an efficiency above 90% at full load. High efficiency combined with the use of a full integrated multilayer PCB magnetic technology has allowed a power density of 51 W/in/sup 3/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Study of Asymmetrical Gating for Phase-Controlled Converters (1972)

The low power factor of phase-controlled converters when the output voltage is less than the maximum is of-concern in high-power equipment. In a converter consisting of two commutating groups in cascade, the usually low power factor can be improved by firing or gating the thyristors in the two groups asymmetrically. One of the groups is fully advanced (or retarded) to minimize its reactive power, while the other group is controlled to give the desired dc Output. The technique is not recommended for single three-phase bridge converters because of third-hannonic output ripple, second-harmonic line current distortion, and danger of commutation failure. These objections are overcome by combining pairs of three-phase bridges. When regeneration is not required, half of the thyristors can be replaced by diodes, reducing the cost. The method should offer substantial improvement in the power factor of cycloconverter ac motor drives as well as dc motor drives.
Preservation techniques for heart transplantation: comparison of hypothermic storage and hypothermic perfusion. (1991)

Preservation of the donor heart is an important and controversial subject in heart transplantation. This study compares simple hypothermic storage and hypothermic perfusion in a swine model of heart transplantation (n = 14). The donor hearts of group A (n = 7) were placed in simple hypothermic storage for 5 hours. The donor hearts of group B (n = 7) were placed onto a perfusion apparatus for 5 hours, with pressure maintained at 28 cm of H2O and a myocardial temperature of 8 to 10 degrees C. In both groups the hearts were initially protected with isosmolar potassium cardioplegic solution. The perfusate in group B contained moderate sodium, mannitol, glucose, insulin, and oxygen. The ischemic interval within both groups was 6 hours including orthotopic transplantation. Investigation was conducted at three time periods: prepreservation, postpreservation, and immediately after loading. For both groups there was nonsignificant depression of myocardial function (cardiac index, stroke index, stroke work index, ejection fraction, and wall stress) at the postpreservation period. After volume loading, for the hypothermic perfusion group there was significant improvement of myocardial function (cardiac index, p less than 0.01; stroke index, p less than 0.01) with no significant change in heart rate, systemic vascular resistance, and systolic blood pressure. There was also significant improvement in myocardial performance (p less than 0.05) for the hypothermic perfusion group after volume loading. Ultrastructural changes were minimal for both groups, and there were no major heart transplantation after 6 hours of ischemia; however, hearts retain their contractile capacity better after hypothermic perfusion than after simple hypothermic storage.(ABSTRACT TRUNCATED AT 250 WORDS)
Advanced 3D Motion Prediction for Video-Based Dynamic Point Cloud Compression (2019)

Point cloud based immersive media representation format has provided many opportunities for extended reality applications and has become widely used in volumetric content capturing scenarios. The high data rate of the point cloud is one of the key problems preventing the adoption of this media format. MPEG Immersive media working group (MPEG-I) aims to create a point cloud compression methodology relying on the existing video coding hardware implementations to solve this problem. However, in the scope of the state-of-the-art video-based dynamic point cloud compression (V-PCC) standard under MPEG-I, the intrinsic 3D object's motion continuity is destroyed by the 2D projections resulting in a significant loss of inter prediction coding efficiency. In this paper, we first propose a general model utilizing the 3D motion and 3D to 2D correspondence to calculate the 2D motion vector (MV). Then under the V-PCC, we propose a geometry-based method using the accurate 3D reconstructed geometry from the 2D geometry video to estimate the 2D MV in the 2D attribute video. In addition, we propose an auxiliary-information-based method using the coarse 3D reconstructed geometry provided by the auxiliary information to estimate the 2D MV in both the 2D geometry and attribute videos. Furthermore, we provide the following two ways to use the estimated 2D MV to improve the coding efficiency. The first one is normative. We propose adding the estimated MV into the advanced motion vector candidate list and find a better motion vector predictor for each prediction unit (PU). The second one is non-normative. We propose applying the estimated MV as an additional candidate of the centers for motion estimation. We implement the proposed algorithms in the V-PCC reference software. The experimental results show that the proposed methods present significant coding gains compared with the current state-of-the-art motion prediction algorithm.
Inactivation of <i>HOXA</i> Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis (2007)

We propose that in addition to the oncogenic role of some HOX family members, other HOX genes are frequent targets for gene inactivation and normally play suppressor roles in leukemia development.
Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells (1997)

The natural product lactacystin exerts its cellular antiproliferative effects through a mechanism involving acylation and inhibition of the proteasome, a cytosolic proteinase complex that is an essential component of the ubiquitin-proteasome pathway for intracellular protein degradation. In vitro, lactacystin does not react with the proteasome; rather, it undergoes a spontaneous conversion (lactonization) to the active proteasome inhibitor, clasto-lactacystin beta-lactone. We show here that when the beta-lactone is added to mammalian cells in culture, it rapidly enters the cells, where it can react with the sulfhydryl of glutathione to form a thioester adduct that is both structurally and functionally analogous to lactacystin. We call this adduct lactathione, and like lactacystin, it does not react with the proteasome, but can undergo lactonization to yield back the active beta-lactone. We have studied the kinetics of this reaction under appropriate in vitro conditions as well as the kinetics of lactathione accumulation and proteasome inhibition in cells treated with lactacystin or beta-lactone. The results indicate that only the beta-lactone (not lactacystin) can enter cells and suggest that the formation of lactathione serves to concentrate the inhibitor inside cells, providing a reservoir for prolonged release of the active beta-lactone.
New Phases of R[sub 3]GaO[sub 6] (R=Rare Earth Elements) and Their Luminescent Properties (2003)

Six new phases with formula earth elements Y, Eu, Tb, Dy, Ho and Er) were prepared and they have iso-structure with orthorhombic The unit cell parameters were refined for all new phases. The ionic radii for 7-coordinated and were obtained by regression analyses, the values of which are 0.1188(2) and 0.1098(1) nm, respectively. In addition, preliminary research was conducted on PL and CL properties of or -doped and Among the phosphors studied in present research, and show bright red, green, and blue luminescence. Further optimizations are necessary to promote their luminescent properties for field emission display applications. © 2003 The Electrochemical Society. All rights reserved.
Capillary HILIC-MS: A New Tool for Sensitive Top-Down Proteomics (2018)

Recent progress in top-down proteomics has driven the demand for chromatographic methods compatible with mass spectrometry (MS) that can separate intact proteins. Hydrophilic interaction liquid chromatography (HILIC) has recently shown good potential for the characterization of glycoforms of intact proteins. In the present study, we demonstrate that HILIC can separate a wide range of proteins exhibiting orthogonal selectivity with respect to reversed-phase LC (RPLC). However, the application of HILIC to the analysis of low abundance proteins (e.g., in proteomics analysis) is hampered by low volume loadability, hindering down-scaling of the method to column diameters below 2.1 mm. Moreover, HILIC-MS sensitivity is decreased due to ion suppression from the trifluoroacetic acid (TFA) often used as the ion-pair agent to improve the selectivity and efficiency in the analysis of glycoproteins. Here, we introduce a capillary-based HILIC-MS method that overcomes these problems. Our method uses RPLC trap-columns to load and inject the sample, circumventing issues of protein solubility and volume loadability in capillary columns (200 μm ID). The low flow rates and use of a dopant gas in the electrospray interface improve protein-ionization efficiencies and reduce suppression by TFA. Overall, this allows the separation and detection of small protein quantities (down to 5 ng injected on column) as indicated by the analysis of a mixture of model proteins. The potential of the new capillary HILIC-MS is demonstrated by the analysis of a complex cell lysate.
Poly(chloropropylmethyl‐dimethylsiloxane)–polyurethane elastomers: Synthesis and properties of segmented copolymers and related zwitterionomers (1986)

Abstract A series of polyurethane block copolymers based on hydroxybutyl terminated poly(chloropropylmethyl‐dimethylsiloxane) and poly(tetramethylene oxide) soft segments of molecular weights 2100 and 2000, respectively, were synthesized. The hard segments consisted of 4,4′‐methylenediphenylene diisocyanate (MDI) that was chain extended with either 1,4‐butanediol (BD) or N‐methyldiethanolamine (MDEA). The materials chain extended with MDEA were ionized using 1,3‐propane sultone. The weight fraction of the hard segments was in the range 0.30–0.45. The effect of mixed soft segments, chain extenders, and zwitterionization on the extent of phase separation and physical properties was studied by utilizing differential scanning calorimetry and dynamic mechanical, stress‐strain, and Fourier Transform Infrared spectroscopy experiments. All of these short segment block copolymers showed nearly complete phase separation. The zwitterionomer materials exhibited ionic aggregation within the hard domains. Although hard segment crystallinity or ionic aggregation did not affect the morphology, hard domain cohesion was important in determining the tensile and viscoelastic properties of these elastomers.
Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering (2015)

The inability to deliver bioactive agents locally in a transient but sustained manner is one of the challenges on the development of bio-functionalized scaffolds for tissue engineering (TE) and regenerative medicine. The mode of release is especially relevant when the bioactive agent is a growth factor (GF), because the dose and the spatiotemporal release of such agents at the site of injury are crucial to achieve a successful outcome. Strategies that combine scaffolds and drug delivery systems have the potential to provide more effective tissue regeneration relative to current therapies. Nanoparticles (NPs) can protect the bioactive agents, control its profile, decrease the occurrence and severity of side effects and deliver the bioactive agent to the target cells maximizing its effect. Scaffolds containing NPs loaded with bioactive agents can be used for their local delivery, enabling site-specific pharmacological effects such as the induction of cell proliferation and differentiation, and, consequently, neo-tissue formation. This review aims to describe the concept of combining NPs with scaffolds, and the current efforts aiming to develop highly multi-functional bioactive agent release systems, with the emphasis on their application in TE of connective tissues.
Toasted soybean flour components with trypsin inhibitor activity (1986)

Abstract Compounds in toasted soybean flour having trypsin inhibitor (TI) activity were isolated and characterized. Sodium hydroxide (0.01N) extracts of toasted soybean flour had an average of 2.59 mg TI/g sample. These extracts, after trichloroacetic acid (TCA) precipitation and dialysis, yielded supernatant and precipitate fractions. Addition of polyvinylpyrrolidone to eliminate free tannins and phenolics in the extracts, which may lead to overestimation of TI activity, was unnecessary. Material balance studies revealed 91% protein recovery and 92% recovery of TI activity in the TCA supernatant (1.1% protein, 2.0% TI) and precipitate (89.8% protein, 90.0% TI) fractions. Column chromatography and electrophoresis showed the TCA supernatant and precipitate fractions to contain proteins, including those having TI activity. Kunitz type TI and Bowman‐Birk type protease inhibitors accounted for most residual TI activity of toasted soybean flour, as verified by column chromatography, isoelectric focusing, sodium dodecyl sulfate polyacrylamide electrophoresis, and size‐exclusion high performance liquid chromatography, using the two similarly treated protease inhibitors as standards. Immunoblotting was also used to detect and identify Kunitz type TI’s in toasted soybean meal extracts. This study established the proteinaceous nature of residual trypsin inhibitor activity in toasted soybean flour and the presence of both Kunitz and Bowman‐Birk inhibitors.
Design of an automated variable configuration die and press for sheet metal forming (1987)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1987.
Transcriptional Activation by a Matrix Associating Region-binding Protein (2001)

Bright (B cell regulator of IgH transcription) is a B cell-specific, matrix associating region-binding protein that transactivates gene expression from the IgH intronic enhancer (E mu). We show here that Bright has multiple contextual requirements to function as a transcriptional activator. Bright cannot transactivate via out of context, concatenated binding sites. Transactivation is maximal on integrated substrates. Two of the three previously identified binding sites in E mu are required for full Bright transactivation. The Bright DNA binding domain defined a new family, which includes SWI1, a component of the SWI.SNF complex shown to have high mobility group-like DNA binding characteristics. Similar to one group of high mobility group box proteins, Bright distorts E mu binding site-containing DNA on binding, supporting the concept that it mediates E mu remodeling. Transfection studies further implicate Bright in facilitating spatially separated promoter-enhancer interactions in both transient and stable assays. Finally, we show that overexpression of Bright leads to enhanced DNase I sensitivity of the endogenous E mu matrix associating regions. These data further suggest that Bright may contribute to increased gene expression by remodeling the immunoglobulin locus during B cell development.