gebhart/patrepeval huggingface dataset:
A Comparative Analysis of Ash Leaf-Colonizing Bacterial Communities Identifies Putative Antagonists of Hymenoscyphus fraxineus (2020)

In the last few years, the alarming spread of <i>Hymenoscyphus fraxineus</i>, the causal agent of ash dieback, has resulted in a substantial threat to native ash stands in central and northern Europe. Since leaves and leaf petioles are the primary infection sites, phyllosphere microorganisms are presumed to interact with the pathogen and are discussed as a source of biocontrol agents. We studied compound leaves from susceptible and visible infection-free trees in four ash stands with a high likelihood of infection to assess a possible variation in the bacterial microbiota, depending on the health status of the trees. The bacterial community was analyzed by culture-independent 16S rRNA gene amplicon sequencing and through the isolation and taxonomic classification of 2,589 isolates using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The bacterial community structure did not show significant differences. However, a set of amplicon sequence variants (ASVs) and MALDI groups belonging to <i>Luteimonas</i>, <i>Aureimonas</i>, <i>Pseudomonas</i>, <i>Bacillus</i>, and <i>Paenibacillus</i> were distinctly increased in tolerant trees, which may be associated with the ability of the tree to resist the pathogen. The most obvious differences were observed for <i>Luteimonas</i>, a genus that is also exclusively present in the healthy core microbiome. In a first <i>in vitro</i> screen of antagonists, approximately 11% of total isolates suppressed the growth of <i>H. fraxineus</i>, but a statistical test with two different <i>H. fraxineus</i> strains confirmed only the antagonistic activity of 8% of these isolates. The antagonistic isolates were assigned to <i>Bacillus velezensis</i>, <i>Pantoea vagans</i>, and <i>Pseudomonas caspiana.</i> Overall, our study provides a set of isolates or phylogenetic groups that might be involved in the process that prevents the penetration and spread of <i>H. fraxineus.</i> In the next step, <i>in planta</i> experiments are required with a longer period of exposure to <i>H. fraxineus</i> to evaluate effective isolates or consortia of isolates acting through direct antagonism or competition or indirectly by inducing resistance.
Selection Value of Phenotypic Attributes in Soybeans<sup>1</sup> (1966)

The average selection index was used to evaluate the contribution of various phenotypic attributes in selection gain for yield, protein, and oil — individually, and in various combinations. Selection gain for yield was maximum hen all attributes were used and selection was for yield alone. Deleting any attribute other than yield did not affect selection gain. Maximum gain for protein and oil (pounds per acre) was obtained from the indices constructed to advance yield; yield and protein; yield and oil; and yield, protein, and oil. Maximum change in percent protein and percent oil was obtained by selecting for these attributes individually, but the total production of oil and protein expressed as pounds per acre was decreased.
Humility and Literature (1925)

Our modern literature has become so self-conscious, analytic, subjective, conventional, and, invariable concomitant of the last, licentious in the true meaning of that word, that it would be an interesting experiment to see if any of the old accomplishment were still possible to it. Owing to our unfortunate acquisition of ‘temperaments,’ ‘view-points’ (loathsome word) and subjective theories of all sorts we have become singularly skilled in distorting language from its proper use as principally to make it the means of telling various kinds of lies which are no more true because they fall into the artistic heresy of subjective sincerity. (And, O Sincerity, what crimes are committed in thy name.) From a psychological point of view these things are doubtless very interesting; and we ought to be very grateful to most of our modern authors for showing us so very instructively how many things can be used for purposes which their Maker never intended : how the English language can be tortured into a parody of German or Greek, and the fine gold of our verbal heritage transmuted, by a devil’s alchemy, into the base tokens of our common speech. But, in the intervals of our scientific raptures, some of us would like, occasionally, to read a little poetry, and, even more, a little prose. The air is full of neologisms unbeautiful, and twisted syntax inexpressive of thought, and not less opaque of feeling . . . ‘But that large utterance of the early Gods,’ where is it?
Short Notices (1973)

Journal Article Short Notices Get access J.E.O. SCREEN J.E.O. SCREEN Birkbeck CollegeLondon Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXXVIII, Issue CCCXLVII, April 1973, Pages 472-a–472, https://doi.org/10.1093/ehr/LXXXVIII.CCCXLVII.472-a Published: 01 April 1973
Secure Multi-pArty Computation Grid LOgistic REgression (SMAC-GLORE) (2016)

In this study, we developed a circuit-based SMAC-GLORE framework. The proposed framework provides a practical solution for secure distributed logistic regression model learning.
Synchronisation using wireless trigger-broadcast for impedance spectroscopy of battery cells (2015)

In electric vehicles, batteries with many cells are used to supply the high voltages needed for the power train. The battery is controlled by a battery management system (BMS) which needs measurement data from each individual cell. Up to now, wired solutions with specialized measurement controllers for battery modules are in use. Some of these communicate over data bus structures. Our group proposes as an alternative solution the use of wireless communication in the near RF field area. The basics of this solutions have already been published [1]. In this article we present more advanced functionality for the wireless sensors approach. A functional module has been developed for impedance spectroscopy of each individual cell in the battery stack during automotive operation. Electrochemical impedance spectroscopy is a powerful method to determine the battery state beyond common and simple models. This technique needs precise and synchronized measurements of the common current and the voltages of the individual cells. A communication and control protocol has been implemented in hard- and software, including a trigger-broadcast operating mode. This solution has to fulfill the time precision requirements of the distributed measurements in the range of a few μs. Therefore, proprietary protocol solutions have been developed. Additional modules in the sensor system allow other functions such as cell balancing and an energy saving wake-up function for the sensor modules. These sensor modules are designed as tailored hardware for integration inside the individual battery cells.
Isolation of telomeric DNA from the filamentous fungus<i>Podospora anserina</i>and construction of a self-replicating linear plasmid showing high transformation frequency (1993)

It has been previously shown that linear plasmids bearing Tetrahymena telomeric sequences are able to replicate autonomously in the filamentous fungus Podospora anserina (1). However, autonomous replication occurs in only 50-70% of the transformants, suggesting a defect in the recognition of the Tetrahymena telomeric template by the putative P. anserina telomerase so that only a fraction of entering DNA is stabilized into linear extrachromosomal molecules. We have cloned DNA sequences added to the Tetrahymena (T2G4)n ends of the linear plasmid. Nucleotide sequencing showed that these sequences are exclusively composed of T2AG3 repeat units. Hybridization experiments of Bal31 treated DNA showed that T2AG3 repeats are confined within 200 bp in chromosomal P. anserina telomeres. A new plasmid has been constructed so that after linearization, the terminal sequences contain T2AG3 repeats. This linear molecule transforms P. anserina with a high frequency (up to 1.75 x 10(4) transformants/micrograms), autonomous replication occurs in 100% of the transformants and the plasmid copy number is about 2-3 per nucleus. These results underscore the importance of the telomeric repeat nucleotide sequence for efficient recognition as functional telomeric DNA in vivo and provide the first step toward the development of an artificial chromosome cloning system for filamentous fungi.
Grain Growth in Microwave‐Annealed Alumina (1991)

Normal grain growth in dense, fine‐grained, aluminum oxide‐0.1 wt% MgO was studied under both conventional furnace and 28‐GHz microwave furnace annealing conditions. The microstructural changes that occurred were the same for both sets of samples; soap bubble microstructures were observed and the aspect ratios and shape factors did not change during the anneals. The kinetics of grain growth were greatly increased by the 28‐GHz microwave anneals; e.g., the grain growth rate at 1500°C in the microwave furnace was the same as the rate at 1700°C in the conventional furnace. Also, the activation energy for grain growth was reduced by the microwave anneal from 590 kJ/mol (conventional) to 480 kJ/mol (microwave). Finally, these results demonstrate that a “microwave effect” can exist in a dense ceramic body and that no free pore‐solid interfaces are necessary.
New Analysis of Direct Exciton Transitions: Application to GaP (1971)

A new analysis of direct exciton data is presented and applied to the ${E}_{0}$, ${E}_{0}+{\ensuremath{\Delta}}_{0}$ transitions in GaP. A curve-fitting procedure is used to compare both the discrete and continuum structure in the data with theoretical curves. Good agreement is obtained for the binding energies, broadening, strengths, and shapes. It is shown that the binding energy of ${E}_{0}$ is 11 \ifmmode\pm\else\textpm\fi{} 1 meV rather than the 5-6-meV value previously obtained from the conventional analysis.
Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities (2007)

The long-term benefits of nitroglycerin therapy are limited by tolerance development. Understanding the precise nature of mechanisms underlying nitroglycerin-induced endothelial cell dysfunction may provide new strategies to prevent tolerance development. In this line, we tested interventions to prevent endothelial dysfunction in the setting of nitrate tolerance. When bovine aortic endothelial cells (BAECs) were continuously treated with nitric oxide (NO) donors, including nitroglycerin, over 2-3 days, basal production of nitrite and nitrate (NO(x)) was diminished. The diminished basal NO(x) levels were mitigated by intermittent treatment allowing an 8-h daily nitrate-free interval during the 2- to 3-day treatment period. Addition of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor apocynin restored the basal levels of NO(x) that were decreased by continuous nitroglycerin treatment of BAECs. Apocynin caused significant improvement of increased mRNA and protein levels of endothelial nitric oxide synthase (eNOS) in BAECs given nitroglycerin continuously over the treatment period. Apocynin also reduced endothelial production of reactive oxygen species (ROS) after continuous nitroglycerin treatment. These results showed an essential similarity to the effects of a nitrate-free interval. Application of the NOS inhibitor N(omega)-nitro- l-arginine methyl ester caused a recovery effect on basal NO(x) and eNOS expression but was without effect on ROS levels in continuously NO donor-treated BAECs. In conclusion, the present study characterized abnormal features and functions of endothelial cells following continuous NO donor application. We suggest that inhibition of NADPH oxidase, by preventing NO donor-induced endothelial dysfunction, may represent a potential therapeutic strategy that confers protection from nitrate tolerance development.
Mineral Ultrafiltration Membranes in Industry (1985)

The technology and components developed for gas phase separation and, more specifically, for isotopic enrichment of uranium by gaseous diffusion, have been adapted to separations in liquid media by SFEC, with the technical backing of the French Atomic Energy Commission. SFEC manufactures "Carbosep" the first mineral membranes in the world commercially available. The industrial use of the advanced membranes is discussed. The concept of "mineral membranes" and their specific properties and characteristics are summarized, and the corresponding industrial modules and ultrafiltration units are then described. Many industrial facilities based on Carbosep membranes are in operation in France and other European countries, treating a wide variety of compounds. This paper deals in particular with: • the food industries: milk, whey, cheese, fruit juices, alcoholic beverages, vinegar, eggs etc., • the biotechnology industries: membrane fermentation reactors, enzyme reactors etc. In these two fields, the ability of Carbosep units to withstand successive steam sterilizations unaffected is most welcome.
Distance dependence of photoinduced long-range electron transfer in zinc/ruthenium-modified myoglobins (1988)

An experimental investigation of the distance dependence of long-range electron transfer in zinc/ruthenium-modified myoglobins has been performed. The modified proteins were prepared by substitution of zinc mesoporphyrin IX diacid (ZnP) for the heme in each of four previously characterized pentaammineruthenium(III) (a_5Ru;a = NH_3) derivatives of sperm whale myoglobin (Mb): a_5Ru(His-48)Mb, a_5Ru(His-12)Mb, a_5Ru(His-116)Mb, a_5Ru(His-81)Mb. Electron transfer from the ZnP triplet excited state (^3ZnP*) to Ru^3+, ^3ZnP*-Ru^3+ → ZnP^+-Ru^2+ (ΔE° ~ 0.8V) was measured by time-resolved transient absorption spectroscopy: rate constants (k_f) are 7.0 × 10^4 (His-48), 1.0 × 10^2 (His-12), 8.9 × 10^1 (His-116), and 8.5 × 10^1 (His-81) s^-1 at 25 °C. Activation enthalpies calculated from the temperature dependences of the electron-transfer rates over the range 5-40 °C are 1.7 ± 1.6 (His-48), 4.7 ± 0.9 (His-12), 5.4 ± 0.4 (His-116), and 5.6 ± 2.5 (His-81) kcal mol^-1. Electron-transfer distances (d = closest ZnP edge to a_5Ru(His) edge; angstroms) were calculated to fall in the following ranges: His-48, 11.8-16.6; His-12, 21.5-22.3; His-116, 19.8-20.4; His-81, 18.8-19.3. The rate-distance equation is k_f = 7.8 × 10^8 exp[-0.9l(d - 3)] s^-1 . The data indicate that the ^3ZnP*-Ru(His-12)^3+ electronic coupling may be enhanced by an intervening tryptophan (Trp-14).
BinCFP: Efficient Multi-threaded Binary Code Control Flow Profiling (2016)

In many tasks of reverse engineering and binary code analysis (e.g., hybrid disassembly, resolving indirect jump, and decoupled taint analysis), the knowledge of detailed dynamic control flow can be of great value. However, the high runtime overhead beset the complete collection of dynamic control flow. The previous efforts on efficient path profiling cannot be directly applied to the obfuscated binary code in which an accurate control flow graph is typically absent. To address these challenges, we present BinCFP, an efficient multi-threaded binary code control flow profiling tool by taking advantage of pervasive multi-core platforms. BinCFP relies on dynamic binary instrumentation to work with the unmodified binary code. The key of BinCFP is a multi-threaded fast buffering scheme that supports processing trace buffers asynchronously. To achieve better performance gains, we also apply a set of optimizations to reduce control flow profile size and instrumentation overhead. Our design enables the complete dynamic control flow collection for an obfuscated binary execution. We have implemented BinCFP on top of Pin. The comparative experiments on SPEC2006 and obfuscated common utility programs show BinCFP outperforms the previous work in several ways. In addition, BinCFP's control flow profile sizes are only about 49.2% that of the conventional design.
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling (2006)

The antitumor potency of the mTOR inhibitor rapamycin (sirolimus) is the subject of intense investigations. Primary effusion lymphoma (PEL) appears as an AIDS-defining lymphoma and like Kaposi sarcoma has been linked to Kaposi sarcoma-associated herpesvirus (KSHV). We find that (1) rapamycin is efficacious against PEL in culture and in a murine xenograft model; (2) mTOR, its activator Akt, and its target p70S6 kinase are phosphorylated in PEL; (3) rapamycin inhibits mTOR signaling as determined by S6 phosphorylation; (4) KSHV transcription is unaffected; (5) inhibition of IL-10 signaling correlates with drug sensitivity; and (6) addition of exogenous IL-10 or IL-6 can reverse the rapamycin growth arrest. This validates sirolimus as a new treatment option for PEL.
Scanning laser tomography Z profile signal width as an objective index of macular retinal thickening (1998)

The evidence of this study, based upon three selected patients with macular retinal thickening and 14 normal subjects, would suggest that Z profile signal width analysis offers a non-invasive, objective, topographic, and reproducible index of macular retinal thickening. Studies employing larger sample sizes are required to determine the true clinical worth of the technique.
Therapeutic Efficacy of Endostatin Exhibits a Biphasic Dose-Response Curve (2005)

We show here that recombinant endostatin protein has a biphasic effect on the inhibition of endothelial cell migration in vitro. In tumor-bearing animals, there is a similar biphasic effect on the inhibition of tumor growth and on circulating endothelial cells after once-daily s.c. injections. This biphasic effect is revealed as a U-shaped curve in which efficacy is optimal between very low and very high doses depending on the tumor type. This result may be applicable to other inhibitors of endothelial growth and to angiogenesis. Furthermore, these results have important implications for clinicians who administer angiogenesis inhibitors for cancer or other angiogenesis-dependent diseases. When these results are taken together with two previous reports of angiogenesis inhibitors with a U-shaped dose-response, they suggest that other regulators of endothelial growth may display a similar pattern.
Biosensors in Clinical Practice: Focus on Oncohematology (2013)

Biosensors are devices that are capable of detecting specific biological analytes and converting their presence or concentration into some electrical, thermal, optical or other signal that can be easily analysed. The first biosensor was designed by Clark and Lyons in 1962 as a means of measuring glucose. Since then, much progress has been made and the applications of biosensors are today potentially boundless. This review is limited to their clinical applications, particularly in the field of oncohematology. Biosensors have recently been developed in order to improve the diagnosis and treatment of patients affected by hematological malignancies, such as the biosensor for assessing the in vitro pre-treatment efficacy of cytarabine in acute myeloid leukemia, and the fluorescence resonance energy transfer-based biosensor for assessing the efficacy of imatinib in chronic myeloid leukemia. The review also considers the challenges and future perspectives of biosensors in clinical practice.
Random Texture Defect Detection Using 1-D Hidden Markov Models Based on Local Binary Patterns (2008)

In this paper a novel method for the purpose of random texture defect detection using a collection of 1-D HMMs is presented. The sound textural content of a sample of training texture images is first encoded by a compressed LBP histogram and then the local patterns of the input training textures are learned, in a multiscale framework, through a series of HMMs according to the LBP codes which belong to each bin of this compressed LBP histogram. The hidden states of these HMMs at different scales are used as a texture descriptor that can model the normal behavior of the local texture units inside the training images. The optimal number of these HMMs (models) is determined in an unsupervised manner as a model selection problem. Finally, at the testing stage, the local patterns of the input test image are first predicted by the trained HMMs and a prediction error is calculated for each pixel position in order to obtain a defect map at each scale. The detection results are then merged by an inter-scale post fusion method for novelty detection. The proposed method is tested with a database of grayscale ceramic tile images.
Phospholipase A2 engineering. 10. The aspartate...histidine catalytic diad also plays an important structural role (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhospholipase A2 engineering. 10. The aspartate...histidine catalytic diad also plays an important structural roleYishan Li and Ming Daw TsaiCite this: J. Am. Chem. Soc. 1993, 115, 19, 8523–8526Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://doi.org/10.1021/ja00072a001Request reuse permissionsArticle Views168Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (464 KB) Get e-Alertsclose Get e-Alerts
Ion Sampling from the Positive Column of dc Discharges in He–Ar Mixtures (1970)

Measurements have been made of the ion species present in the positive column of dc discharges of 0.05% and 0.5% argon in helium, by sampling through a 35-μ-diam orifice in the wall of the discharge tube. Data for 0.05% argon has been obtained over a current range of 15–90 mA and for pressures from 3 to 30 Torr. The main ion species observed were Ar+, He+, and He2+. Theoretical analysis combined with measurements of the variation of Ar+ with distance from the cathode, enable estimates to be made of the degree of ionization of Ar, and also an upper limit for the helium metastable particle densities present in the discharge. Metastable density values are, in general, an order-of-magnitude larger than the electron densities.