gebhart/patrepeval huggingface dataset:
Distinct Hippocampal Expression Profiles of Long Non-coding RNAs in an Alzheimer’s Disease Model (2016)

Alzheimer's disease (AD), the most prevalent form of dementia worldwide, is a complex neurodegenerative disease characterized by the progressive loss of memory and other cognitive functions. The pathogenesis of AD is not yet completely understood. Although long non-coding RNAs (lncRNAs) have recently been shown to play a role in AD pathogenesis, the specific influences of lncRNAs in AD remain largely unknown; in particular, hippocampal lncRNA expression profiles in AD rats are lacking. In this study, microarray analysis was performed to investigate the hippocampal expression patterns of dysregulated lncRNAs in a rat model of AD. A total of 315 lncRNAs and 311 mRNAs were found to be significantly dysregulated in the AD model (≥2.0 fold, p < 0.05). Then, quantitative real-time PCR was used to validate the expression of selected lncRNAs and mRNAs. Bioinformatics tools and databases were employed to explore the potential lncRNA functions. This is the first study to comprehensively identify dysregulated hippocampal lncRNAs in AD and to demonstrate the involvement of different lncRNA expression patterns in the hippocampal pathogenesis of AD. This information will enable further research on the pathogenesis of AD and facilitate the development of novel AD therapeutics targeting lncRNAs.
Service sector – A pillar of Indian economy (2011)

India's growth performance over the past decade has been the strength of its services sector. The emergence of services as the most dynamic sector of the Indian economy has in many ways been a revolution. This paper considers the recent growth of India's services sector. The high growth of services output in the 1990s was mostly due to the rapid expansion of communication, banking, business services (including the IT sector) and community services. While factors such as a high income elasticity of demand for services, increasing input usage of services by other sectors, and rising exports, were important in boosting services growth in the 1990s, supply side factors including reforms and technological advances also played significant roles. Going forward, the growth potential of Indian services exports is well known, but the paper also finds considerable scope for growth in the Indian service economy provided that deregulation continues. In addition, the paper shows that service sectors contribution to GDP growth in India and problems of service sector in India.
Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics (2016)

Mitochondria influence cardiac electrophysiology through energy- and redox-sensitive ion channels in the sarcolemma, with the collapse of energetics believed to be centrally involved in arrhythmogenesis. This study was conducted to determine if preservation of mitochondrial membrane potential (ΔΨm) contributes to the antiarrhythmic effect of exercise. We utilized perfused hearts, isolated myocytes, and isolated mitochondria exposed to metabolic challenge to determine the effects of exercise on cardiac mitochondria. Hearts from sedentary (Sed) and exercised (Ex; 10 days of treadmill running) Sprague-Dawley rats were perfused on a two-photon microscope stage for simultaneous measurement of ΔΨm and ECG. After ischemia-reperfusion, the collapse of ΔΨm was commensurate with the onset of arrhythmia. Exercise preserved ΔΨm and decreased the incidence of fibrillation/tachycardia (P < 0.05). Our findings in intact hearts were corroborated in isolated myocytes exposed to in vitro hypoxia-reoxygenation, with Ex rats demonstrating enhanced redox control and sustained ΔΨm during reoxygenation. Finally, we induced anoxia-reoxygenation in isolated mitochondria using high-resolution respirometry with simultaneous measurement of respiration and H2O2 Mitochondria from Ex rats sustained respiration with lower rates of H2O2 emission than Sed rats. Exercise helps sustain postischemic mitochondrial bioenergetics and redox homeostasis, which is associated with preserved ΔΨm and protection against reperfusion arrhythmia. The reduction of fatal ventricular arrhythmias through exercise-induced mitochondrial adaptations indicates that mitochondrial therapeutics may be an effective target for the treatment of heart disease.
Construction of gene libraries for each human chromosome (1990)

We describe the construction of two complete sets of small insert, complete digest DNA libraries for each of the 24 human chromosomal types by the National Laboratory Gene Library Project. Flow sorting was used to purify the chromosomes which provided the DNA for cloning. One set of libraries was cloned into the HindIII site of the lambda vector Charon 21A, and the other set was cloned into the EcoRI site of the same vector. Characterization information from both in-house experiments and user feedback is presented. These chromosome-specific libraries are available to the general scientific community from a repository at the American Type Culture Collection, Rockville, MD. The second phase of the project, the construction of large insert, partial digest libraries in both lambda and cosmid vectors, is underway.
Catalysis by di-n-butyltin oxide of a tertiary ketol rearrangement: synthesis of intermediates and analogues of valine and isoleucine biosynthesis (1987)

Di-n-butyltin oxide efficiently catalyses the rearrangement of 3-hydroxy-2-oxocarboxylic acid esters into the corresponding 2-hydroxy-3-oxo-esters, in a reaction that simulates the reversible rearrangement catalysed by the enzyme reductiosomerase.
OFDM Blind Parameter Identification in Cognitive Radios (2006)

In this paper we introduce a blind parameter identification algorithm for Orthogonal Frequency Division Multiplexing (OFDM) signals. The algorithm correlation-based processes automatically estimate all parameters of OFDM signals with a blind process that works from a limited amount of data without any prior information. We also derive novel identification performances of algorithms under various conditions, assuming actual conditions in feasible systems: data offset, AWGN, frequency offset, and fading channels. The algorithm is essential for two systems: first, Cognitive Radios, one of the most exciting being radios that change fundamental parameters frequently to provide high throughput and high quality of services; and, second, Radio Monitoring Systems that detect illegal signals transmitted by unlicensed devices.
Self-Assembly and Disassembly of Regioregular, Water Soluble Polythiophenes:  Chemoselective Ionchromatic Sensing in Water (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationSelf-Assembly and Disassembly of Regioregular, Water Soluble Polythiophenes: Chemoselective Ionchromatic Sensing in WaterRichard D. McCullough, Paul C. Ewbank, and Robert S. LoeweView Author Information Department of Chemistry, Carnegie Mellon University Pittsburgh, Pennsylvania 15213 Cite this: J. Am. Chem. Soc. 1997, 119, 3, 633–634Publication Date (Web):January 22, 1997Publication History Received24 October 1996Revised22 November 1996Published online22 January 1997Published inissue 1 January 1997https://pubs.acs.org/doi/10.1021/ja963713jhttps://doi.org/10.1021/ja963713jrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views2567Altmetric-Citations261LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cations,Organic polymers,Phase transitions,Plastics,Polymers Get e-Alerts
Perceived control, depressive symptomatology, and professional burnout: A review of the evidence (1996)

Abstract The term “burnout” refers to a syndrome of emotional exhaustion, depersonalization, and reduced personal accomplishment that can occur in human service professionals. There are now over 2,000 publications on the topic. This paper reviews a subset of the literature concerned with burnout, depressive symptomatology, and perceptions of job control. It appears that the first two constructs share appreciable variance but are not isomorphic. Research also indicates that the development of burnout has a modest association with perceptions of job uncontrollability (i.e., perceived lack of autonomy and little decisional latitude). A conceptual model proposing that perceived uncontrollability induces depression indirectly. by operating through differences in the magnitude of burnout received only equivocal support in longitudinal studies. Prospective designs were proposed as a high priority for future burnout research. Other recommendations for future research included rests of a model that hypothesizes frustrated achievement striving as a key etiological factor in the development of burnout and depressive affect.
Complete genome sequencing of <i>Anaplasma marginale</i> reveals that the surface is skewed to two superfamilies of outer membrane proteins (2004)

The rickettsia Anaplasma marginale is the most prevalent tick-borne livestock pathogen worldwide and is a severe constraint to animal health. A. marginale establishes lifelong persistence in infected ruminants and these animals serve as a reservoir for ticks to acquire and transmit the pathogen. Within the mammalian host, A. marginale generates antigenic variants by changing a surface coat composed of numerous proteins. By sequencing and annotating the complete 1,197,687-bp genome of the St. Maries strain of A. marginale, we show that this surface coat is dominated by two families containing immunodominant proteins: the msp2 superfamily and the msp1 superfamily. Of the 949 annotated coding sequences, just 62 are predicted to be outer membrane proteins, and of these, 49 belong to one of these two superfamilies. The genome contains unusual functional pseudogenes that belong to the msp2 superfamily and play an integral role in surface coat antigenic variation, and are thus distinctly different from pseudogenes described as byproducts of reductive evolution in other Rickettsiales.
Generating Realistic Camera Shake for Virtual Scenes (2014)

JVRB, 10(2013), no. 7. - When depicting both virtual and physical worlds, the viewer's impression of presence in these worlds
is strongly linked to camera motion. Plausible and artist-controlled camera movement can substantially
increase scene immersion. While physical camera motion exhibits subtle details of position, rotation,
and acceleration, these details are often missing for virtual camera motion. In this work, we analyze camera movement using signal theory. Our system allows us to stylize a smooth user-defined virtual base camera motion
 by enriching it with plausible details. A key component of our system is a database of videos filmed by physical
 cameras. These videos are analyzed with a camera-motion estimation algorithm (structure-from-motion) and labeled
 manually with a specific style. By considering spectral properties of location, orientation and acceleration, our
 solution learns camera motion details. Consequently, an arbitrary virtual base motion, defined in any conventional
 animation package, can be automatically modified according to a user-selected style. In an animation package
 the camera motion base path is typically defined by the user via function curves. Another possibility is to obtain
 the camera path by using a mixed reality camera in motion capturing studio. As shown in our experiments, the
 resulting shots are still fully artist-controlled, but appear richer and more physically plausible.
Available transfer capability assessment of the Malaysian power system (2003)

In the deregulated power system, it is important to accurately and rapidly quantify the available transfer capability (ATC) of the transmission system. This paper presents a case study of the ATC assessment on the Malaysian power system. The ATC is evaluated using both the proposed quadratic sensitivity method and the AC power flow method. The ATC are evaluated by considering both the point-to-point transfer and the area-to-area transfer. Initially, contingency screening and ranking techniques are used to define the critical lines in the system and these lines are considered in the ATC assessment. Numerous simulations have been carried out to calculate the ATCs by considering voltage and line security limits as well as voltage stability limits. Simulation results are analyzed with regard to the effectiveness and accuracy of the proposed quadratic sensitivity and the AC power flow methods.
Calculation of laser absorption by metal powders in additive manufacturing (2015)

We have calculated the absorption of laser light by a powder of metal spheres, typical of the powder employed in laser powder-bed fusion additive manufacturing. Using ray-trace simulations, we show that the absorption is significantly larger than its value for normal incidence on a flat surface, due to multiple scattering. We investigate the dependence of absorption on powder content (material, size distribution, and geometry) and on beam size.
Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet (2016)

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic treatment for people with epilepsy, but not all patients become free of seizures. The ketogenic diet is one treatment option for drug-resistant patients. Both types of therapy exert their clinical effects through interactions with one or more of a diverse set of molecular targets in the brain. ASDs act by modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; by enhancement of γ-aminobutyric acid (GABA)-mediated inhibition through effects on GABAA receptors, the GABA transporter 1 (GAT1) GABA uptake transporter, or GABA transaminase; through interactions with elements of the synaptic release machinery, including synaptic vesicle 2A (SV2A) and α2δ; or by blockade of ionotropic glutamate receptors, including α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors. The ketogenic diet leads to increases in circulating ketones, which may contribute to the efficacy in treating pharmacoresistant seizures. Production in the brain of inhibitory mediators, such as adenosine, or ion channel modulators, such as polyunsaturated fatty acids, may also play a role. Metabolic effects, including diversion from glycolysis, are a further postulated mechanism. For some ASDs and the ketogenic diet, effects on multiple targets may contribute to activity. Better understanding of the ketogenic diet will inform the development of improved drug therapies to treat refractory seizures.
Single-crystal barium titanate thin films by ion slicing (2003)

Thin barium titanate films, 0.5–8 μm thick, are obtained from a single-crystal bulk sample using ion slicing. The process, based on ion implantation and anodic bonding, separates thin films having areas of ∼1×1 cm2, from bulk crystals. The quality of the film is characterized by measurement of surface roughness and dielectric properties. The film permittivity retains its single-crystal value.
Patterned optical ribbon fibre with fibre physicalcontact connector for optical fibre interconnection (1997)

The authors propose a novel optical fibre interconnection component for use with printed circuit boards. The component consists of fibre ribbon which is moulded into a wiring pattern and terminated with a newly developed multiple fibre physical contact (FPC) connector. A patterned 32 fibre ribbon with 8-fibre FPC connectors is described which has a low insertion loss of 0.22 dB and a high return loss of 61.7 dB.
A 1.1-GHz CMOS fractional-N frequency synthesizer with a 3-b third-order /spl Delta//spl Sigma/ modulator (2000)

A 1.1-GHz fractional-N frequency synthesizer is implemented in 0.5-/spl mu/m CMOS employing a 3-b third-order /spl Delta//spl Sigma/ modulator. The in-band phase noise of -92 dBc/Hz at 10-kHz offset with a spur of less than -95 dBc is measured at 900.03 MHz with a phase detector frequency of 7.994 MHz and a loop bandwidth of 40 kHz. Having less than 1-Hz frequency resolution and agile switching speed, the proposed system meets the requirements of most RF applications including multislot GSM, AMPS, IS-95, and PDC.
MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine (2021)

Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired. Repair of injury to the cell membrane is an important aspect of physiology. Inadequate membrane repair function is implicated in the pathophysiology of many human disorders. Recent studies show that Mitsugumin 53 (MG53), a TRIM family protein, plays a key role in repairing cell membrane damage and facilitating tissue regeneration. Clarifying the role of MG53 and its molecular mechanism are important for the application of MG53 in regenerative medicine. In this review, we analyze current research dissecting MG53's function in cell membrane repair and tissue regeneration, and highlight the development of recombinant human MG53 protein as a potential therapeutic agent to repair multiple-organ injuries.
HYDROPHOBIC ADSORPTION CHROMATOGRAPHY OF PEACH POLYPHENOL OXIDASE (1980)

ABSTRACT Peach fruit polyphenol oxidase, both crude and pure preparations, were found to adsorb to Phenyl Sepharose, 4‐phenylbutylamine Sepharose, CBZ‐phenylalanine‐TETA‐alkyl Sepharose, octyl‐ and decyl‐agarose columns. The enzyme showed no affinity to amino‐alkyl agaroses, hydrophobic media with terminal phenol, amino, or carboxyl groups on the ligands. The enzyme is weakly hydrophobic and can be purified and characterized with hydrophobic chromatography. Phenyl Sepharose CL‐4B columns gave the best separation of isoenzyme forms of the enzyme probably due to biospecitic effect in addition to the hydrophobic interactions.
An RFLP map for 2q33‐q37 from multicase mycobacterial and leishmanial disease families: no evidence for an <i>Lsh/Ity/Bcg</i> gene homologue influencing susceptibility to leprosy (1993)

The mycobacterial diseases leprosy and tuberculosis (TB) and the leishmaniases are characterized by a wide spectrum of disease phenotypes, and by the fact that the majority of individuals exposed to the causative organisms Mycobacterium leprae, M. tuberculosis and Leishmania sp. become infected but do not present with clinical disease. In order to determine whether a human homologue to the murine macrophage resistance gene Lsh/Ity/Bcg influences susceptibility to human disease, multicase families for all three diseases have been collected, and linkage analysis performed using a panel of markers in the region of human chromosome 2q33-q37 known to be conserved with the Lsh/Ity/Bcg-containing region of murine chromosome 1. Because of the paucity of available polymorphic markers/linkage information for 2q33-q37, data from 35 multicase leprosy, TB and visceral leishmaniasis families (310 individuals) were first pooled to produce a detailed RFLP map of the region. Peak LOD scores well in excess of 3 were observed for linkage between adjacent pairs of a more proximal (2q33-q35) set of markers CRYGP1, MAP2, FN1, TNP1, VIL1 and DES, and between adjacent pairs of a more distal (2q35-q37) set COL6A3, D2S55 and D2S3. These peak LOD scores and the corresponding values for theta were used in the MAP92 program to generate a multiple two-point map with gene order/map intervals (cM) of: CRYGP1-4.65-MAP2-3.45-FN1-5.95-TNP1-3.41-VIL1-3. 01- DES-20.14-COL6A-10.91-D2S55-3.67-D2S3. Although local support for the placement of loci in this order was weak (LOD < 2, except for DES-COL6A3 where LOD = 6.02), the map is consistent with the gene order for those loci (Cryg, Fn-1, Tp-1, Vil, Des, Col6a3) previously mapped in the mouse. Data from 17 multicase leprosy families (149 individuals) were further analysed for linkage between a putative disease susceptibility locus (DSL) controlling susceptibility to leprosy per se and each of the marker loci. Assuming 100% penetrance for the susceptibility allele, no positive LOD score was obtained for linkage between the DSL and any of the marker genes. Instead, the data provide convincing evidence (LOD scores < -2) that a DSL does not fall within 10-20 cM of CRYGP1, MAP2, TNP1, VIL1, DES or D2S55, or within 5-10 cM of FN1, COL6A3 or D2S3. This effectively excludes a putative DSL controlling susceptibility to leprosy per se from the entire region 2q33-q37.(ABSTRACT TRUNCATED AT 400 WORDS)
Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues (2010)

Foetal stem cells (FSCs) can be isolated during gestation from many different tissues such as blood, liver and bone marrow as well as from a variety of extraembryonic tissues such as amniotic fluid and placenta. Strong evidence suggests that these cells differ on many biological aspects such as growth kinetics, morphology, immunophenotype, differentiation potential and engraftment capacity in vivo. Despite these differences, FSCs appear to be more primitive and have greater multi-potentiality than their adult counterparts. For example, foetal blood haemopoietic stem cells proliferate more rapidly than those found in cord blood or adult bone marrow. These features have led to FSCs being investigated for pre- and post-natal cell therapy and regenerative medicine applications. The cells have been used in pre-clinical studies to treat a wide range of diseases such as skeletal dysplasia, diaphragmatic hernia and respiratory failure, white matter damage, renal pathologies as well as cancers. Their intermediate state between adult and embryonic stem cells also makes them an ideal candidate for reprogramming to the pluripotent status.
Water Photolysis by a Photoeleetrochemical Cell Using an Immobilized Chloroplasts-Methyl Viologen System (1984)

An immobilized chloroplast film, prepared by immobilizing spinach chloroplasts in 2 wt% agar gel, was attached to a SnO2 optically transparent electrode to obtain the immobilized chloroplast film electrode. The immobilized chloroplast film electrode worked as a photoanode under illumination in the presence of methyl viologen, which was an electron carrier from chloroplasts to the SnO2 optically transparent electrode. Water photolysis for producing hydrogen by a photoelectrochemical cell using the immobilized chloroplasts film electrode was successfully achieved. A smooth platinum electrode was used as a cathode to produce hydrogen. The pH and temperature of the anolyte were kept at 7.8 and 25°C. Optimizations of the concentrations of methyl viologen and chlorophyll in the immobilized chloroplast film were studied. The optimum thickness for the immobilized chloroplast film was about 0.8 mm. The immobilized chloroplasts had higher storage stability than that of isolated chloroplasts and they retained more than 50% of the initial activities of photosystem I and photosystem II after 10 days when they were stored at 4°C in the dark. It was conceived from the relationship between the photocurrent and the photosystem I and II activities that the main cause for the decrease in the photocurrent was the photochemical inactivation of photosystem II.