gebhart/patrepeval huggingface dataset:
Dispersion in segmented flow through glass tubing in continuous-flow analysis: the ideal model (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDispersion in segmented flow through glass tubing in continuous-flow analysis: the ideal modelL. R. Snyder and H. J. AdlerCite this: Anal. Chem. 1976, 48, 7, 1017–1022Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/ac60371a013https://doi.org/10.1021/ac60371a013research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
STIMULANT PROPERTIES OF BROMOCRIPTINE ON CENTRAL DOPAMINE RECEPTORS IN COMPARISON TO APOMORPHINE, (+)‐AMPHETAMINE AND <scp>l</scp>‐DOPA (1976)

1. The activity of bromocriptine has been investigated in tests for the stimulation of central dopaminergic mechanisms. The results obtained have been compared with those of apomorphine, (+)-amphetamine and L-DOPA. 2. Bromocriptine (2.5 to 10 mg/kg) induced stereotyped sniffing and licking in rats. The stereotypy was more intense than that induced by L-DOPA and less intense than that of apomorphine and (+)-amphetamine over the dose ranges studied. 3. In rats lesioned unilaterally in the substantia nigra by local injection of 6-hydroxydopamine, bromocriptine, like apomorphine and L-DOPA, induced turning contralateral to the side of the lesion. The smallest dose of bromocriptine to induce turning was 0.5 mg/kg. 4. Reserpine-induced catalepsy in mice was antagonized by bromocriptine, with an ED50 of 1.8 mg/kg. It was intermediate in potency to apomorphine and L-DOPA. 5. Spontaneous locomotor activity in mice was stimulated by bromocriptine in a dose-dependent manner from 2.5 to 10 mg/kg after an initial suppression of activity. 6. In all experiments, bromocriptine was characterized by a prolonged duration of activity after a delay in the onset of effect. 7. The stereotyped behaviour induced by bromocriptine was inhibited by prior administration of pimozide, reserpine or alpha-methyl-p-tyrosine. 8. Bromocriptine-induced turning behaviour was abolished by pretreatment with pimozide, and reduced after alpha-methyl-p-tyrosine treatment. 9. The results obtained support the conclusion that bromocriptine acts by stimulating dopamine receptors in the central nervous system and that intact catecholamine synthesis and granular amine storage mechanisms are necessary for it to bring about its effects.
Simple surface engineering of polydimethylsiloxane with polydopamine for stabilized mesenchymal stem cell adhesion and multipotency (2015)

Polydimethylsiloxane (PDMS) has been extensively exploited to study stem cell physiology in the field of mechanobiology and microfluidic chips due to their transparency, low cost and ease of fabrication. However, its intrinsic high hydrophobicity renders a surface incompatible for prolonged cell adhesion and proliferation. Plasma-treated or protein-coated PDMS shows some improvement but these strategies are often short-lived with either cell aggregates formation or cell sheet dissociation. Recently, chemical functionalization of PDMS surfaces has proved to be able to stabilize long-term culture but the chemicals and procedures involved are not user- and eco-friendly. Herein, we aim to tailor greener and biocompatible PDMS surfaces by developing a one-step bio-inspired polydopamine coating strategy to stabilize long-term bone marrow stromal cell culture on PDMS substrates. Characterization of the polydopamine-coated PDMS surfaces has revealed changes in surface wettability and presence of hydroxyl and secondary amines as compared to uncoated surfaces. These changes in PDMS surface profile contribute to the stability in BMSCs adhesion, proliferation and multipotency. This simple methodology can significantly enhance the biocompatibility of PDMS-based microfluidic devices for long-term cell analysis or mechanobiological studies.
Low-Temperature Approach to Highly Emissive Copper Indium Sulfide Colloidal Nanocrystals and Their Bioimaging Applications (2013)

We report our newly developed low-temperature synthesis of colloidal photoluminescent (PL) CuInS2 nanocrystals (NCs) and their in vitro and in vivo imaging applications. With diphenylphosphine sulphide (SDPP) as a S precursor made from elemental S and diphenylphosphine, this is a noninjection based approach in 1-dodecanethiol (DDT) with excellent synthetic reproducibility and large-scale capability. For a typical synthesis with copper iodide (CuI) as a Cu source and indium acetate (In(OAc)3) as an In source, the growth temperature was as low as 160 °C and the feed molar ratios were 1Cu-to-1In-to-4S. Amazingly, the resulting CuInS2 NCs in toluene exhibit quantum yield (QY) of ~23% with photoemission peaking at ~760 nm and full width at half maximum (FWHM) of ~140 nm. With a mean size of ~3.4 nm (measured from the vertices to the bases of the pyramids), they are pyramidal in shape with a crystal structure of tetragonal chalcopyrite. In situ (31)P NMR (monitored from 30 °C to 100 °C) and in situ absorption at 80 °C suggested that the Cu precursor should be less reactive toward SDPP than the In precursor. For our in vitro and in vivo imaging applications, CuInS2/ZnS core-shell QDs were synthesized; afterwards, dihydrolipoic acid (DHLA) or 11-mercaptoundecanoic acid (MUA) were used for ligand exchange and then bio-conjugation was performed. Two single-domain antibodies (sdAbs) were used. One was 2A3 for in vitro imaging of BxPC3 pancreatic cancer cells. The other was EG2 for in vivo imaging of a Glioblastoma U87MG brain tumour model. The bioimaging data illustrate that the CuInS2 NCs from our SDPP-based low-temperature noninjection approach are good quality.
Deblurring by Realistic Blurring (2020)

Existing deep learning methods for image deblurring typically train models using pairs of sharp images and their blurred counterparts. However, synthetically blurring images do not necessarily model the genuine blurring process in real-world scenarios with sufficient accuracy. To address this problem, we propose a new method which combines two GAN models, i.e., a learning-to-Blur GAN (BGAN) and learning-to-DeBlur GAN (DBGAN), in order to learn a better model for image deblurring by primarily learning how to blur images. The first model, BGAN, learns how to blur sharp images with unpaired sharp and blurry image sets, and then guides the second model, DBGAN, to learn how to correctly deblur such images. In order to reduce the discrepancy between real blur and synthesized blur, a relativistic blur loss is leveraged. As an additional contribution, this paper also introduces a Real-World Blurred Image (RWBI) dataset including diverse blurry images. Our experiments show that the proposed method achieves consistently superior quantitative performance as well as higher perceptual quality on both the newly proposed dataset and the public GOPRO dataset.
Bis-indenyl molybdenum(iv) halide complexes: synthesis and X-ray studies (2002)

A stepwise route to bis-indenyl halide derivatives of molybdenum is reported. Treatment of [Ind2Mo(CO)2][BF4]2 with one equivalent of Bu4NBr in CH2Cl2 yielded [Ind2Mo(CO)Br][BF4] (1). When 1 was refluxed in NCMe and irradiated with a 60 W tungsten bulb [Ind2Mo(NCMe)Br][BF4] (2) was isolated. The reaction of [Ind2Mo(CO)Br][BF4] with LiBr afforded Ind2MoBr2 (3). The Ind2MoCl2 (4) analogue has been prepared directly by reaction of [Ind2Mo(CO)2][BF4]2 with LiCl.
A layered framework strategy for deploying high assurance VPNs (2002)

Deploying VPNs (Virtual Private Networks), especially in a large-scale environment, requires much planning. Based on actual implementation experience, we propose a layered framework that can be used to distribute VPN deliverables among different workgroups. Despite the perception that a VPN is not a customizable solution, we conclude there is a broad range of VPN options available with corresponding trade-offs. This framework supports advanced planning to maximize trade-offs depending on individualized requirements.
Loss of cell polarity causes severe brain dysplasia in <i>Lgl1</i> knockout mice (2004)

Disruption of cell polarity is seen in many cancers; however, it is generally considered a late event in tumor progression. Lethal giant larvae (Lgl) has been implicated in maintenance of cell polarity in Drosophila and cultured mammalian cells. We now show that loss of Lgl1 in mice results in formation of neuroepithelial rosette-like structures, similar to the neuroblastic rosettes in human primitive neuroectodermal tumors. The newborn Lgl1(-/-) pups develop severe hydrocephalus and die neonatally. A large proportion of Lgl1(-/-) neural progenitor cells fail to exit the cell cycle and differentiate, and, instead, continue to proliferate and die by apoptosis. Dividing Lgl1(-/-) cells are unable to asymmetrically localize the Notch inhibitor Numb, and the resulting failure of asymmetric cell divisions may be responsible for the hyperproliferation and the lack of differentiation. These results reveal a critical role for mammalian Lgl1 in regulating of proliferation, differentiation, and tissue organization and demonstrate a potential causative role of disruption of cell polarity in neoplastic transformation of neuroepithelial cells.
Assisted assembly: how to improve a de novo genome assembly by using related species (2009)

We describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.
Genotyping of <i>Enterococcus faecalis</i> and <i>Enterococcus faecium</i> Isolates by Use of a Set of Eight Single Nucleotide Polymorphisms (2010)

A single nucleotide polymorphism (SNP) genotyping method for Enterococcus faecalis and Enterococcus faecium was developed using the "Minimum SNPs" program. SNP sets were interrogated using allele-specific real-time PCR. SNP typing subdivided clonal complexes 2 and 9 of E. faecalis and 17 of E. faecium, members of which cause the majority of nosocomial infections globally.
Alexa, Siri, Cortana, and More: An Introduction to Voice Assistants (2018)

Voice assistants are software agents that can interpret human speech and respond via synthesized voices. Apple's Siri, Amazon's Alexa, Microsoft's Cortana, and Google's Assistant are the most popular voice assistants and are embedded in smartphones or dedicated home speakers. Users can ask their assistants questions, control home automation devices and media playback via voice, and manage other basic tasks such as email, to-do lists, and calendars with verbal commands. This column will explore the basic workings and common features of today's voice assistants. It will also discuss some of the privacy and security issues inherent to voice assistants and some potential future uses for these devices. As voice assistants become more widely used, librarians will want to be familiar with their operation and perhaps consider them as a means to deliver library services and materials.
Paramagnetic Lanthanide(III) complexes as pH‐sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications (2002)

The recently introduced new class of contrast agents (CAs) based on chemical exchange saturation transfer (CEST) may have a huge potential for the development of novel applications in the field of MRI. In this work we explored the CEST properties of a series of Lanthanide(III) complexes (Ln = Eu, Dy, Ho, Er, Tm, Yb) with the macrocyclic DOTAM-Gly ligand, which is the tetraglycineamide derivative of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). These complexes possess two pools of exchangeable protons represented by the coordinated water and the amide protons. Yb-DOTAM-Gly displays the most interesting CEST properties when its amide N-H resonance (16 ppm upfield H2O signal) is irradiated. Up to 70% suppression of the water signal is obtained at pH 8. As the exchange rate of amide protons is base-catalyzed, Yb-DOTAM-Gly results to be an efficient pH-responsive probe in the 5.5-8.1 pH range. Moreover, a ratiometric method has been set up in order to remove the dependence of the observed pH responsiveness from the absolute concentration of the paramagnetic agent. In fact, the use of a mixture of Eu-DOTAM-Gly and Yb-DOTAM-Gly, whose exchangeable proton pools are represented by the coordinated water (ca. 40 ppm downfield H2O signal at 312K) and amide protons, respectively, produces a pH-dependent CEST effect which is the function of the concentration ratio of the two complexes.
Expert database systems (1987)

Abstract Expert database systems represent a new class of system architectures that support knowledge-based applications requiring access to large, shared databases. This paper explores the concepts, took, techniques and architectures that comprise this new and dynamic field. Expert database systems allow the specification, prototyping and implementation of knowledge-based information systems that represent a vertical extension beyond the well-defined, predictable, transaction-oriented systems to those with knowledge-directed reasoning and interpretation under conditions of uncertainty.
Arrhythmias in Primary Pulmonary Hypertension (1979)

Through the examination of 171 electrocardiograms (ECG) of 101 patients with primary pulmonary hypertension (PPH), the following conclusions were obtained. Arrhythmias were found in 27 (26.7%) of the 101 patients. Among the surviving cases, arrhythmias were found in 8 (17.8%) out of 45 patients, but among the decreased cases, the figure was higher, 19 (33.9%) out of 56. There were instances of more than one kind of arrhythmias in the same patient and a total of 34 types of arrhythmias were noted. The main types of arrhythmias were sinus tachycardia (13 cases), sinus bradycardia (6 cases), and first degree A-V block (5 cases), which accounted for 70% of the total. Sinus tachycardia was observed in only 2 of the survivors but in 11 of the decreased cases, which showed a significant difference (p less than 0.05). First A-V block were all induced by digitalis. Wenckebach type of second degree A-V block was noted in only 1 case and it was also induced by digitalis. Since severe attacks of ventricular arrhythmias were very rare in these cases with PPH, it is difficult to consider the Adams-Stokes syndrome as the cause of syncopal attacks or sudden death. However, it is necessary to further investigate nodal functions by means of continuous ECG monitoring, the overdrive suppression test and His bundle ECGs.
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy (2014)

Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and mantle cell lymphoma. However, proteasome inhibitors have not proved effective in treating other cancers, and this has called into question the general applicability of this approach. Here, I consider possible explanations for this apparently limited applicability, and discuss whether inhibiting other broadly acting components of the ubiquitin-proteasome system - including ubiquitin-activating enzyme and the AAA-ATPase p97/VCP - might be more generally effective in cancer therapy.
Bump in the Ether: Mobile Phones as Proxies for Sensitive Input (2018)

User-space malware such as keyboard sniffers, spyware, and Trojans represent a significant threat to today’s desktop computing environment. Users have little assurance that such malware cannot observe their input to a particular application. In this paper, we present Bump in the Ether (BitE), an approach for preventing malware from accessing sensitive user input and providing the user with additional confidence that her input is being processed as desired. Rather than preventing malware from running or detecting already-running malware, we facilitate user input that bypasses common avenues of attack. User input traverses a trusted tunnel from the input device to the application. This trusted tunnel is implemented using a trusted user device working in tandem with a TCG-compliant host platform. The user device verifies the integrity of the host platform and application, provides a trusted display through which the user selects the application to which her inputs should be directed, and encrypts those inputs so that only the application can decrypt them. We describe the design and implementation of BitE, with emphasis on both usability and security issues.
Efficient techniques for secure multiparty computation on mobile devices (2015)

Smartphones are rapidly becoming a widespread computation platform, with many users relying on their mobile devices as their primary computing device. This popularity has brought about a plethora of mobile applications and services which are designed to efficiently make these limited devices a viable source of entertainment and productivity. This is commonly accomplished by moving the critical application computation to a Cloud or application server managed by the application developer. Unfortunately, the significant number of breaches experienced by mobile application infrastructure and the accompanying loss of private user data indicates the need for stronger security and privacy guarantees before this model of computation can become ubiquitous.\nThe cryptographic community has developed the field of secure multiparty computation (SMC) to allow applications to perform computation over encrypted data. Such a protocol would allow mobile users to keep their private information encrypted while still enjoying the convenience of their Cloud based applications. However, while SMC protocols have seen significant advances in efficiency on desktop and server class machines, they currently require more computation power and memory than is available on commodity smartphones. Furthermore, even as smartphone computational power increases, the mobile-specific limitations of network bandwidth and power usage will always stand as barriers to efficiently executing SMC protocols.\nThis dissertation develops techniques for outsourcing the costly operations in garbled circuit SMC protocols to an untrusted Cloud to allow resource-constrained devices to use this cryptographic primitive. By providing the mobile device with a third party Cloud provider, we show that it is possible for a mobile device to execute a garbled circuit with an application server at approximately the same efficiency as the same computation run between two server class machines. We first show two protocols for outsourcing the garbled circuit evaluation and generation. We develop a novel outsourced oblivious transfer (OOT) protocol to make this type of outsourcing possible. Second, we develop a black box technique for outsourcing any two-party SMC protocol, and show that the overhead incurred by outsourcing is minimal. Finally, we develop a protocol for outsourcing SMC that pro- vides both input privacy and circuit privacy, preventing the assisting Cloud from learning anything about the computation besides the fact that it took place. Through the protocols and the empirical evaluations in this dissertation, we show that executing SMC protocols on mobile devices can be done with comparable efficiency to the desktop platform, and provide techniques to allow for such computation using the latest developments in secure computation.
The effects of long‐term elevation of air temperature and CO on the frost hardiness of Scots pine (1996)

ABSTRACT The frost hardiness of 20 to 25‐year‐old Scots pine ( Pinus sylvestris L.) saplings was followed for 2 years in an experiment that attempted to simulate the predicted climatic conditions of the future, i.e. increased atmospheric CO 2 concentration and/or elevated air temperature. Frost hardiness was determined by an electrolyte leakage method and visual damage scoring on needles. Elevated temperatures caused needles to harden later and deharden earlier than the controls. In the first year, elevated CO 2 enhanced hardening at elevated temperatures, but this effect disappeared the next year. Dehardening was hastened by elevating CO 2 in both springs. The frost hardiness was high (<−40 °C), even at elevated temperatures, in midwinter, at which time the electrolyte leakage method underestimated the frost hardiness compared with the visual scoring. In addition to the significant differences between treatments, there was also significant variation between trees in frost hardiness within treatments. These results suggest that the risks of frost damage are marked in the predicted climatic conditions in Finland, and, more specifically, they depend on how the occurrence of the frost episodes changes with respect to climatic warming during the annual cycle, especially in the autumn and spring. We also conclude that the conditions in midwinter are not critical for frost injury to trees in the future.
A Randomized Study of Low-Dose Interleukin-2 Subcutaneous Immunotherapy versus Interleukin-2 plus Interferon-Alpha as First Line Therapy for Metastatic Renal Cell Carcinoma (1993)

The present results, which require confirmation in a larger series, indicate that combination with IFN does not increase the efficacy of IL-2 subcutaneous immunotherapy in metastatic RCC but only the toxicity of treatment.
Numerical propagation of spatially distributed acoustic sources using the exterior Helmholtz integral equation (2003)

A finite difference approximation of the Helmholtz equation numerically integrated over a measurement surface can determine the acoustic field throughout an entire volume of a homogeneous region outside. This approach has been developed and implemented to study acoustic fields radiating from large immersed structures from pressure data measured over a generalized cylindrical measurement surface. The numerical algorithm is described, and simulation examples are presented. The results show pressure, velocity, and intensity distributions both in the evanescent wave region of the geometric nearfield and in the acoustic farfield.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>