gebhart/patrepeval huggingface dataset:
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer (2010)

Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively. Numerous studies have suggested that increased TS levels are associated closely with resistance to fluoropyrimidine-based chemotherapy. TAS-102 is a novel drug containing trifluorothymidine, which is phosphorylated by TK-1 to its active monophosphated form, that in turn can inhibit TS. TAS-102 has been shown to exhibit antitumor activity in fluoropyrimidine-resistant human cancer cells. TAS-102 is currently undergoing clinical trials for use in gastrointestinal cancers. In the present study, we used immunohistochemistry to investigate the expression of TK-1 and TS in various types of cancer. TK-1 and TS expression was markedly different between cancer types. High TK-1 expression was detected prominently in gastrointestinal adenocarcinomas and esophageal and uterine squamous cell carcinomas. Gastrointestinal adenocarcinomas and squamous cell uterine carcinomas were often accompanied by high TS expression, indicating activation of pyrimidine synthesis through both the salvage and de novo pathways. These results led us to consider that TAS-102 may also be effective for esophageal and uterine squamous cell carcinomas, as well as for gastrointestinal adenocarcinomas, even in fluoropyrimidine-resistant cases with high TS expression. In contrast, thyroid papillary carcinomas, lung adenocarcinomas, hepatocellular carcinomas, pancreatic ductal carcinomas, and renal cell carcinomas, which exhibit low TK-1 expression, may be resistant to TAS-102. In non-small cell lung cancers, high TK-1 expression was demonstrated in squamous cell carcinomas, but not in adenocarcinomas. This result suggests that TAS-102 efficacy and the pyrimidine synthetic pathway may differ depending on histological type. Our results indicate that administration of TAS-102 could be selected on the basis of the immunohistochemical evaluation of TK-1 and TS.
Assembly Design Ontology for Service-Oriented Design Collaboration (2006)

Hair designing is one of crucial components of the hair simulation tasks.The efficiency of hair modeling is very much determined by the interactivity and the ease-to-use the designing tools within an application.This paper presents a unified framework that uses the various key techniques developed for specific tasks in hair simulation and to realize the ultimate goal of 'virtual hairdressing room' that is simple to use but quite effective for generating fast hairstyles.Successful attempts have been made to handle the different challenging issues involved in simulation of hair at interactive rates.Effort has been put in developing methodologies for hair shape modeling, hair dynamics and hair rendering.A user friendly interface controlled by a haptic device facilitates designer's interactivity with the hairstyles.Furthermore, designer's visualization is enhanced by using real time animation and interactive rendering.Animation is done using a modified Free Form Deformation (FFD) technique that has been effectively adapted to various hairstyles.Hair Rendering is performed using an efficient scattering based technique, displaying hair with its various optical effects.
Prophylaxis against Gallstone Formation with Ursodeoxycholic Acid in Patients Participating in a Very-Low-Calorie Diet Program (1995)

Objective: To determine whether prophylactic treatment with ursodeoxycholic acid can prevent gallstone formation in persons participating in a very-low-calorie weight reduction diet program. Design: Multicenter, double-blind, placebo-controlled, multidose clinical trial. Patients were treated with placebo or with 300 mg/d, 600 mg/d, or 1200 mg/d of ursodeoxycholic acid. Setting: 31 Health Management Resources weight management centers. Patients: 1004 patients were initially enrolled in a 16-week, 520-kcal/d, Health Management Resources liquid protein diet program. All patients had a body mass index of 38 kg/m2 or more and a normal gallbladder ultrasonogram before study entry. Bile analysis was done in 32 patients. Measurements: Body weight and body mass index were measured before the diet was started and at 2-week intervals for 16 weeks. Gallbladder ultrasonography was done before enrollment and after 8 and 16 weeks of dieting. Bile was obtained by endoscopy and analyzed for cholesterol crystals and lipid levels. Results: Mean body weight for all patients at the start of dieting was 128.2 kg ±23.2 kg; mean initial body mass index was 44.2 kg/m2 ±6.0 kg/m2. Gallstones developed in 28% (95% CI, 22% to 35%) of patients receiving placebo, in 8% (CI, 5% to 13%) of patients treated with 300 mg/d of ursodeoxycholic acid, in 3% (CI, 1% to 7%) of patients treated with 600 mg/d of ursodeoxycholic acid, and in 2% (CI, 0.5% to 5%) of patients treated with 1200 mg/d of ursodeoxycholic acid. The differences between patients receiving placebo and patients receiving ursodeoxycholic acid were statistically significant. The percentage of ursodeoxycholic acid in bile increased stepwise with increasing doses of ursodeoxycholic acid. Conclusions: Ursodeoxycholic acid, 600 mg/d, is highly effective in preventing gallstone formation in patients having dietary-induced weight reduction. For a listing of additional persons involved in the conduct of this study, see Appendix.
Clinical economics review: medical management of inflammatory bowel disease (1999)

Inflammatory bowel diseases, although they are uncommon and rarely fatal, typically present during the period of economically productive adult life. Patients may require extensive therapeutic intervention as a result of the chronic, relapsing nature of the diseases. Their medical management includes oral and topical 5-amino salicylic acid derivatives and corticosteroids, as well as antibiotics and immunosuppressive therapies. Assessing the cost-effectiveness of rival treatments requires valid, reliable global assessments of outcome which consider quality of life, as well as the usual clinical end-points. Macro-economic studies of the overall impact of inflammatory bowel disease on health care systems have so far been largely confined to North America, where the total annual US costs, both direct and indirect, incurred by the estimated 380 000-480 000 sufferers has been put at around US2bn. Drugs were estimated to account for only 10% of total costs, whereas surgery and hospitalization account for approximately half. Studies from Europe suggest that the proportion of patients with Crohn's disease and ulcerative colitis who are capable of full time work is 75% and 90%, respectively. However, whilst only a minority of inflammatory bowel disease patients suffer chronic ill health and their life expectancy is normal, obtaining life assurance may be problematic, suggesting a misconception that inflammatory bowel disease frequently results in a major impact on an individual's economic productivity.
Performance Analysis of Probabilistic Multipath Transmission of Video Streaming Traffic over Multi-Radio Wireless Devices (2012)

Popular smart wireless devices become equipped with multiple radio interfaces. Multihoming support can be enabled to allow for multiple simultaneous associations with heterogeneous networks. In this study, we focus on video streaming traffic and propose analytical approaches to evaluate the packet-level and call-level performance of a multipath transmission scheme, which sends video traffic bursts over multiple available channels in a probabilistic manner. A probability generation function (PGF) and z-transform method is applied to derive the PGF of packet delay and any arbitrary moment in general. Particularly, we can obtain the average delay, delay jitter, and delay outage probability. The essential characteristics of video traffic are taken into account, such as deterministic burst intervals, highly dynamic burst length, and batch arrivals of transmission packets. The video substream traffic resulting from the probabilistic flow splitting is characterized by means of zero-inflated models. Further, the call-level performance, in terms of flow blocking probability and system throughput, is evaluated with a three-dimensional Markov process and compared with that of an always-best access selection. The numerical and simulations results demonstrate the effectiveness of our analysis framework and the performance gain of multipath transmission.
Infantile haemangioma expresses embryonic stem cell markers (2012)

The novel expression of hESC on two different populations of cells in proliferating IH and their inability to form teratomas in vivo infer the presence of a primitive cellular origin for IH downstream from hESC.
Policies Compatible with an Integrated World Economy (1988)

The analysis in the previous chapter leads to two important conclusions. First, continuous economic progress requires constant adaptation and change in economic organisation as well as in the rules and conventions which guide economic behaviour. This applies to all phases of economic development and to each level of economic activity. Second, with greater international integration and interdependence, the character of the world economic environment has become distinctly oligopolistic in the last quarter of the twentieth century. International economic developments are dominated by the objectives and policies of a relatively small number of large industrial nations and, to a lesser extent, a few oil producers. However, while each of them can have a perceptible influence on the growth and stability of other economies, none is large enough to impose a particular economic order on the rest of the world and manage the international economy accordingly. Equally, no sovereign state is willing to hand over to a supranational authority the right to determine its economic objectives and policies.
Analytical Profiles Of Drug Substances: Volume 13 (1976)

Contents

Aminophylline...1
Ascorbic Acid...45
Captopril...79
Cefotaxime...139
Cefoxitin, Sodium...169
Clofibrate...197
Clotrimazole...225
Dopamine Hydrochloride...257
Ergonovine Maleate...273
Flufenamic Acid...313
Hexestrol...347
Mestranol...375
Noscapine...407
Panicillin-G Benzathine...463
Phenylbutazone...483
Sulfadiazine...523
Model-Transformation Design Patterns (2014)

This paper defines a catalogue of patterns for the specification and design of model transformations, and provides a systematic scheme and classification of these patterns, together with pattern application examples in leading model transformation languages such as ATL, QVT, GrGen.NET, and others. We consider patterns for improving transformation modularization and efficiency and for reducing data storage requirements. We define a metamodel-based formalization of model transformation design patterns, and measurement-based techniques to guide the selection of patterns. We also provide an evaluation of the effectiveness of transformation patterns on a range of different case studies.
On a continuation approach to regularization for crosswell tomography (1999)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1999On a continuation approach to regularization for crosswell tomographyAuthors: Kenneth P. BubeRobert T. LanganKenneth P. BubeUniversity of Washington and Robert T. LanganChevron Petroleum Technology Co.https://doi.org/10.1190/1.1820747 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1820747FiguresReferencesRelatedDetailsCited byDeep learning for velocity model building with common-image gather volumes22 September 2021 | Geophysical Journal International, Vol. 228, No. 2Crosswell seismic imaging for deep gas reservoir characterizationGang Yu, Bruce Marion, Brad Bryans, Pedro Carrillo, Wankui Guo, Yanming Pang, and Fanzhong Kong5 November 2008 | GEOPHYSICS, Vol. 73, No. 6A continuation approach to regularization of ill-posed problems with application to crosswell-traveltime tomographyKenneth P. Bube and Robert T. Langan1 October 2008 | GEOPHYSICS, Vol. 73, No. 5Nonlinear shaping regularization in geophysical inverse problemsSergey Fomel15 December 2008First arrival stochastic tomography: Automatic background velocity estimation using beam semblances and VFSAChaoshun Hu, Paul Stoffa, and Kirk McIntosh15 December 2008Shaping regularization in geophysical-estimation problemsSergey Fomel15 February 2007 | GEOPHYSICS, Vol. 72, No. 2A homotopy method for well-log constraint waveform inversionBo Han, Hongsun Fu, and Hong Liu15 November 2006 | GEOPHYSICS, Vol. 72, No. 1Attenuation coefficient tomogram and Q distribution image from crosswell survey in the Northern Reef Trend of Michigan BasinPedro Carrillo, Milagrosa Aldana, Brad Bryans, and Roger Turpening14 September 2007A homotopy method for nonlinear inverse problemsApplied Mathematics and Computation, Vol. 183, No. 2First-break vertical seismic profiling tomography for Vinton Salt DomeHua-wei Zhou26 May 2006 | GEOPHYSICS, Vol. 71, No. 3Large well‐spacing crosswell seismic imaging for deep gas reservoir mapping and descriptionGuo Wankui, Pang Yanming, Kong Fanzhong, Gang Yu, Brad Bryans, and Bruce Marion6 October 2006A Regularization Homotopy Method for the Inverse Problem of 2-D Wave Equation and Well Log Constraint Inversion31 May 2013 | Chinese Journal of Geophysics, Vol. 48, No. 6Shaping regularization in geophysical estimation problemsSergey Fomel7 December 2005A Homotopy Method for Solving the Impedance Inversion of 1-D Wave Equation31 May 2013 | Chinese Journal of Geophysics, Vol. 47, No. 6 SEG Technical Program Expanded Abstracts 1999ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1999 Pages: 2061 publication data© 1999 Copyright © 1999 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 04 Jan 2005 CITATION INFORMATION Kenneth P. Bube and Robert T. Langan, (1999), "On a continuation approach to regularization for crosswell tomography," SEG Technical Program Expanded Abstracts : 1295-1298. https://doi.org/10.1190/1.1820747 Plain-Language Summary PDF DownloadLoading ...
Demonstration that human B cells respond differently to interleukin 2 and B cell differentiation factor based on their stages of maturation. (1986)

The mechanisms whereby interleukin 2 (IL 2), interferon-gamma (IFN-gamma), and B cell differentiation factor (BCDF) alone or in combination modulate human B cell differentiation are currently under intensive study. To dissect out the effects of individual lymphokines contained in mixed lymphocyte reaction-culture supernatants (MLR-CS) on B cell differentiation, we employed pure factors that possessed the same activity as factors contained in MLR-CS (IL 2: 50 U/ml, IFN-gamma: 7 U/ml, BCDF-Nal: 5 pM/ml, BCDF-YA2: 12.5% v/v) singly and in combination to human B cells. By activating purified human B cells with Staphylococcus aureus Cowan I (SAC) for 3 days, separating B blast cells by the Percoll centrifugation method, and then either using these B blast cells as B cells in the earlier stage after SAC-activation, or further culturing these B blast cells for 4 more days without any stimuli and using these B cells as B cells in the later stage after SAC-activation, we could define two different populations of cells. Disparity in the populations could be demonstrated by the observation that B cells in the earlier stage were 81.2% Tac-antigen+, 23.2% B2+, 68.9% transferrin receptor+, and 90.5% HLR-DR+, whereas B cells in the later stage were observed to be less positive for each surface antigen: 36.1% Tac-Ag+, 8.3% B2+, 45.3% transferrin receptor+, and 58.7% HLR-DR+. By adding each factor to both B cell fractions, we also demonstrated functional differences in the two populations. B cells in the earlier stage of activation only differentiated in response to IL 2 or IL 2 + IFN-gamma but not to BCDF, which was in contrast to B cells in the later stage that did not differentiate in response to IL 2 but did differentiate to BCDF. However, B cells in both stages proliferated in response to IL 2 but not to BCDF. Finally, we separated B cells in the later stage into two populations by the Percoll discontinuous gradient centrifugation. Lower density (larger) B cells were observed to proliferate but not to differentiate in response to IL 2, whereas higher density (smaller) B cells were observed to differentiate in response to BCDF. Therefore, we conclude that activated B cells initially become large and gain Tac-Ag and differentiate in response to IL 2 alone as well as the combination of IL 2 and IFN-gamma, whereas later in the more mature stage they become smaller again and differentiate into Ig-secreting cells only in response to BCDF.
A translated corpus of 30,000 French SMS (2006)

All in-text\treferences\tunderlined\tin\tblue\tare\tlinked\tto\tpublications\ton\tResearchGate, letting you\taccess\tand\tread\tthem\timmediately.
Dynamic Rehabilitation of the Paralyzed Face: III: Balanced Coupling of Oral and Ocular Musculature from the Intact Side in the Canine (1991)

We have recently demonstrated the feasibility of artificial agonist/antagonist coupling between intact facial and reinnervated strap muscles in the rabbit. The present study broadens this principle to involve bi-level cross-facial innervation. After severing the facial innervation unilaterally in four dogs, a nerve pedicle from a cervical motor nerve was implanted into the orbicularis oris and from the deep temporal nerve into the orbicularis oculi. After neurotization (5.6 months), the pedicles were electrically stimulated to verify muscular response. Graded contraction on the intact side was induced by stimulating the ipsilateral facial nerve with currents of various pulse widths. The resulting compression of a strain gauge on the intact face triggered a two-channel, opto-isolated, pulse width-modulated stimulator to produce agonistic graded contraction at one level of the reinnervated side (e.g., oral) and reciprocal relaxation in its reinnervated counterpart (e.g., ocular). The sophistication of the present model--as compared to the original pilot study--brings us one step closer to dynamic human facial rehabilitation.
A Genetic Approach to Idiotypic Vaccination for B Cell Lymphomaa (1995)

Idiotypic immunoglobulin expressed by a B cell tumor presents a clear tumor antigen which could be attacked by vaccination of the host. Vaccination with idiotypic protein has been shown to induce protective immunity against lymphoma, but application to patients is limited by the requirement of "personal" vaccines for each patient. A genetic approach enables V-region sequences encoding idiotypic antigen to be rescued from tumor biopsies, and to be assembled as scFv fragments. These can be expressed in bacteria to produce recombinant protein, or used directly as naked DNA vaccines. Intramuscular injection of idiotypic DNA from a mouse B cell lymphoma induces low levels of syngeneic anti-idiotypic antibody in serum. Response can be stimulated by co-injection of DNA plasmids encoding either IL-2 or GM-CSF, and T cells which proliferate in response to idiotypic IgM are generated. However, protection against tumor appears to be blocked by continuing secretion of idiotypic antigen from the persisting vaccine vector, which forms immune complexes with serum antibody. Methods for regulating the level of scFv to engage the immune system, but not to block the effector arm are being investigated. Similar control will be applicable to the cytokine vectors, which can deliver encoded cytokines designed to activate immune pathways for tumor destruction. Experience gained in lymphoma may be extended to other tumors with defined tumor antigens.
Compact planar inverted‐F patch antenna for triple‐frequency operation (2002)

Abstract A novel compact planar inverted‐F patch antenna with two shorted branch strips for triple‐frequency operation at about 900, 1800, and 2450 MHz is presented. The antenna has compact dimensions of 5.5 mm in height and 7.5 × 24 mm 2 in area. The two shorted branch strips are printed on an FR4 substrate, and supported above a ground plane by plastic posts. In addition, the longer branch strip, which controls the operations at about 900 and 1800 MHz, is printed on both sides of the FR4 substrate, leading to the reduction in antenna dimensions. On the other hand, the shorter branch strip, printed on one side of the FR4 substrate only, controls the operation at about 2450 MHz. Details of the antenna design and experimental results are presented and discussed. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 33: 459–462, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10350
Association of of Atrial Fibrillation Clinical Phenotypes With Treatment Patterns and Outcomes (2017)

Cluster analysis identified 4 clinically relevant phenotypes of AF that each have distinct associations with clinical outcomes, underscoring the heterogeneity of AF and importance of comorbidities and substrates.
An autonomous energy harvesting station-keeping vehicle for Persistent Ocean Surveillance (2011)

The Johns Hopkins University Applied Physics Laboratory developed an autonomous sailing vessel for persistent ocean surveillance. The unmanned autonomous surface vehicle is capable of extracting wind, water turbine, and solar energy from the local environment for long-term station-keeping as part of DARPA's Persistent Ocean Surveillance Program. The vehicle is capable of withstanding a 1 m/s (2-kt) current and varying littoral sea states to maintain a specified watch radius. The unmanned sailing vehicle uses an autonomously controlled sail and auxiliary thruster that are integrated with GPS, an anemometer (wind speed and direction), three-axis accelerometers, and compass to allow for station-keeping. An initial prototype was designed and developed in 2005, culminating in an at-sea station-keeping demonstration in March 2006. The prototype was successful in station-keeping under sail power 91% of the 24 hour demonstration period. A second-generation prototype that incorporates Iridium communications, solar cells, and an acoustic sensor was designed, developed and tested. Results from the testing demonstrations of the initial and the second generation prototypes will be discussed.
Biosignal pattern recognition and interpretation systems. 3. Methods of classification (1994)

The following topics are discussed: Bayes/minimum distance classifiers; maximum likelihood classification estimation; k-nearest neighbor classification; entropy criteria; syntactic techniques; string matching; the Cocke-Younger-Kasami parsing algorithm; syntactic learning; finite-state automata; neural network classification techniques; learning vector quantization; cluster swapping; hierarchial clustering procedures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Justificación socioeconómica y política para invertir en la Agricultura de Conservación (2005)

Measurements were made of the extended x-ray absorption fine structure (EXAFS) of the iron site in photosynthetic reaction centers from the bacterium Rhodopseudomonas sphaeroides. Forms with two quinones, two quinones with added o-phenanthroline, and one quinone were studied. Only the two forms containing two quinones maintained their integrity and were analyzed. The spectra show directly that the added o-phenanthroline does not chelate the iron atom. Further analysis indicates that the iron is octahedrally coordinated by nitrogen and/or oxygen atoms located at various distances, with the average value of about 2.14 A. The analysis suggests that most of the ligands are nitrogens and that three of the nitrogen ligands belong to histidine rings. This interpretation accounts for several unusual features of the EXAFS spectrum. We speculate that the quinones are bound to the histidine rings in some manner. Qualitative features of the absorption edge spectra also are discussed and are related to the Fe-ligand distance.