gebhart/patrepeval huggingface dataset:
Modification of Amino Groups in Inhibitors of Proteolytic Enzymes<sup>*</sup> (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModification of Amino Groups in Inhibitors of Proteolytic Enzymes*Royce Haynes, David T. Osuga, and Robert E. FeeneyCite this: Biochemistry 1967, 6, 2, 541–547Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://doi.org/10.1021/bi00854a023RIGHTS & PERMISSIONSArticle Views361Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (587 KB) Get e-Alerts Get e-Alerts
Sirolimus, a New, Potent Immunosuppressive Agent (1997)

Sirolimus (SRL), a potent immunosuppressant, is currently being investigated in phase III trials for prophylaxis of renal transplant rejection. The mechanism of action of SRL is a blockade of the response of T and B cells to cytokines, thereby preventing cell cycle progression in G1 and consequently cell proliferation. There seems to be a good correlation between SRL concentrations, estimated as exposure by the area under the concentration versus time curve, and trough whole blood concentration, so that therapeutic monitoring may be done by trough levels only. Because of the low frequency of allograft rejection, there has been no documented correlation between trough concentrations and efficacy. Trough SRL concentrations of 15 ng/ml or higher seem to be associated with an increased frequency of adverse effects. Drug-associated toxicities include thrombocytopenia, leukopenia, and increases in cholesterol and triglyceride levels. The drug has synergy with cyclosporine (CsA) in vitro as well as in animal and clinical studies. In phase II trials the combination of SRL-CsA therapy reduced the frequency of acute rejection episodes, permit withdrawal of concomitant corticosteroid therapy, and allowed reduction of CsA dosages in nonblack patients.
Mutations in the RAS‐MAPK, PI(3)K (phosphatidylinositol‐3‐OH kinase) signaling network correlate with poor survival in a population‐based series of colon cancers (2008)

The RAS-MAPK, PI (3)K signaling pathways form a network that play a central role in tumorigenesis. The BRAF, KRAS and PI3KCA genes code 3 partners of this network and have been found to be activated by mutation in colorectal cancer; these mutations lead to unrestricted cell growth. We evaluated the clinicopathological features and the prognosis of patients with activated-network colon cancers in a population-based study. A total of 586 colon adenocarcinomas were evaluated using sequencing for mutations of KRAS and PI3KCA, and allelic discrimination for mutation of BRAF. Clinicopathological characteristics were correlated to the risk of bearing a mutation of the network using logistic regression. Three-year survival rates were compared with the Log rank test. A multivariate survival analysis using the Cox model was performed. After adjustment for age and microsatellite instability, activation of the network by mutation of at least 1 of the 3 genes was significantly associated with female sex (p = 0.02) and proximal location (p < 0.001). Lower levels of 3-year survival were associated with activation of the network by mutation of at least 1 of the 3 genes (59.4 and 69.4%, respectively; p = 0.009). These results remained significant in a multivariate analysis adjusted for sex, age, location, stage and microsatellite instability (HR = 1.48; CI CI(95%) = [1.07-2.04]). Our study is the first report to underline the potential role of RAS-MAPK, PI (3)K network mutations on survival in colon cancers. Because of the role of this signaling network on anticancer agents, the evaluation of its mutations could have clinical implications.
Dominant Sets and Pairwise Clustering (2006)

We develop a new graph-theoretic approach for pairwise data clustering which is motivated by the analogies between the intuitive concept of a cluster and that of a dominant set of vertices, a notion introduced here which generalizes that of a maximal complete subgraph to edge-weighted graphs. We establish a correspondence between dominant sets and the extrema of a quadratic form over the standard simplex, thereby allowing the use of straightforward and easily implementable continuous optimization techniques from evolutionary game theory. Numerical examples on various point-set and image segmentation problems confirm the potential of the proposed approach.
A novel approach to intelligent scheduling based on fuzzy feature selection and fuzzy classifier (2003)

Intelligent scheduling policy is needed for dynamic manufacturing systems, which tailors the dispatching rule adaptively depending on the prevailing state of the system. In this kind of system-features-oriented intelligent scheduling method, appropriately choosing the group of system features is very critical to scheduling performance. However, research efforts on this topic are limited. In this article, based on general fuzzy model and heuristic searching tree, a new quantitative method is proposed to evaluate and reduce the system features. Then, an intelligent scheduler using fuzzy classifier is created, which can present fuzzy or uncertainty cases. The fuzzy classifier is constructed by fuzzy neural network. Tests of simulation and contrast show that, through applying fuzzy logic in intelligent scheduling framework, the learning performance of classifier and scheduling performance of scheduler are both improved. In conclusion, the fuzzy feature selection and fuzzy pattern classifier methods have great potential in improving the performance of intelligent scheduler.
Impact of Hierarchical Memory Systems On Linear Algebra Algorithm Design (1988)

Linear algebra algorithms based on the BLAS or ex tended BLAS do not achieve high performance on mul tivector processors with a hierarchical memory system because of a lack of data locality. For such machines, block linear algebra algorithms must be implemented in terms of matrix-matrix primitives (BLAS3). Designing ef ficient linear algebra algorithms for these architectures requires analysis of the behavior of the matrix-matrix primitives and the resulting block algorithms as a func tion of certain system parameters. The analysis must identify the limits of performance improvement possible via blocking and any contradictory trends that require trade-off consideration. We propose a methodology that facilitates such an analysis and use it to analyze the per formance of the BLAS3 primitives used in block methods. A similar analysis of the block size-perfor mance relationship is also performed at the algorithm level for block versions of the LU decomposition and the Gram-Schmidt orthogonalization procedures.
Real-time dsp for reflected power cancellation in FMCW radars (2005)

A novel real-time DSP scheme is proposed for leakage cancellation in monostatic frequency modulated continuous wave (FMCW) radars. With the digital implementation, the proposed scheme shows a much more precise control of the leakage cancellation, compared to conventional analog implementation. Other advantages also include that the DC offset existing in analog mixers, affecting the cancellation performance, are eliminated. A radar test bed at 26 GHz has been built. The measurement results show more than 40 dB suppression in transmitter leakage, which proves the effectiveness of the proposed approach.
Human seminal clusterin (SP-40,40). Isolation and characterization. (1990)

Molecular cloning of the human complement inhibitor SP-40,40, has revealed strong homology to a major rat and ram Sertoli cell product, sulfated glycoprotein-2, known also as clusterin. This study reports the purification and characterization of human seminal clusterin. Two-dimensional gel electrophoresis revealed charge differences between clusterin purified from semen and the serum-derived material. Both preparations demonstrate comparable hemagglutination (clustering) activity and inhibition of C5b-6 initiated hemolysis. The average clusterin concentration in normal seminal plasma is considerably higher than that found in serum. Mean seminal plasma clusterin concentrations were significantly lower in azoospermia caused by obstruction or seminiferous tubule failure than with oligospermia or normospermia. Only men with vasal agenesis had undetectable seminal clusterin, suggesting that some of the seminal clusterin is produced by the seminal vesicles. Immunofluorescence of human spermatozoa revealed that clusterin was detected on 10% of spermatozoa, predominantly those that were immature or had abnormal morphology. A pilot study of 25 patients suggests that seminal clusterin concentration, together with sperm motility and morphology, is correlated with the fertilization rate in vitro. The function of seminal clusterin is unknown. Its extensive distribution in the male genital tract and its high concentration in seminal plasma suggests an important role in male fertility.
Effects of RP 55778, a tumor necrosis factor alpha synthesis inhibitor, on antiviral activity of dideoxynucleosides (1997)

Tumor necrosis factor alpha (TNF-alpha) is overexpressed during human immunodeficiency virus (HIV) infection. RP 55778, a TNF-alpha synthesis inhibitor, decreases HIV replication in monocytes/macrophages. Therapeutic use of RP 55778 in vivo, like that of other biological response modifiers, would theoretically require association with dideoxynucleosides. We have evaluated here the combinatory effects of zidovudine (AZT) or dideoxyinosine (ddI) and RP 55778. This TNF-alpha inhibitor antagonizes the antiviral effects of both dideoxynucleosides, especially AZT. The more favorable anti-HIV activity of ddI in resting cells may explain these unequal degrees of antagonism.
Piecewise interferometric generation of precision gratings (1977)

A simple interferometer and associated technique, allowing for sequential exposure of small segments in the writing of a large grating, is described. The increased intensity thus afforded greatly aids in overcoming nonlinear and reciprocity effects in the recording medium. Furthermore, the technique eliminates the need for a large collimator and errors introduced by imperfect collimation. Demonstration gratings written with this technique have shown maximum registration errors of +/-35 nm.
Exploiting Background Knowledge for Relation Extraction (2010)

Relation extraction is the task of recog-nizing semantic relations among entities. Given a particular sentence supervised ap-proaches to Relation Extraction employed feature or kernel functions which usu-ally have a single sentence in their scope. The overall aim of this paper is to pro-pose methods for using knowledge and re-sources that are external to the target sen-tence, as a way to improve relation ex-traction. We demonstrate this by exploit-ing background knowledge such as rela-tionships among the target relations, as well as by considering how target rela-tions relate to some existing knowledge resources. Our methods are general and we suggest that some of them could be ap-plied to other NLP tasks. 1
Performance of a Permanent-Magnet Axial-Field d.c. Machine (1979)

The performance of permanent-magnet d.c. disc-armature motors is discussed. Calculation of the field distribution allows this to be accurately predicted, and it also permits study of power losses associated with commutation. It is found that, when several pairs of brushes are used with a wave-wound armarure, and each is located opposite a different pole, then every brush will carry terminal current only intermittently. This effect severely degrades motor performance, and indicates that, whenever possible, only a single brush pair should be used with this winding. If additional current capacity is required, then extra brushes should be added opposite the same two poles.
Organometallic reaction mechanisms. XII. Mechanism of methylmagnesium bromide addition to benzonitrile (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganometallic reaction mechanisms. XII. Mechanism of methylmagnesium bromide addition to benzonitrileE. C. Ashby, Li-Chung. Chao, and H. M. NeumannCite this: J. Am. Chem. Soc. 1973, 95, 15, 4896–4904Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://doi.org/10.1021/ja00796a022RIGHTS & PERMISSIONSArticle Views923Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model (2006)

Iron overload does not appear to affect lesion establishment but may contribute to the further growth of endometriosis by promoting cell proliferation of lesions. Iron chelator treatment could therefore be beneficial in endometriosis to prevent iron overload in the pelvic cavity and decrease cellular proliferation of lesions.
Looking for bugs in all the right places (2006)

We continue investigating the use of a negative binomial regression model to predict which files in a large industrial software system are most likely to contain many faults in the next release. A new empirical study is described whose subject is an automated voice response system. Not only is this system's functionality substantially different from that of the earlier systems we studied (an inventory system and a service provisioning system), it also uses a significantly different software development process. Instead of having regularly scheduled releases as both of the earlier systems did, this system has what are referred to as "continuous releases." We explore the use of three versions of the negative binomial regression model, as well as a simple lines-of-code based model, to make predictions for this system and discuss the differences observed from the earlier studies. Despite the different development process, the best version of the prediction model was able to identify, over the lifetime of the project, 20% of the system's files that contained, on average, nearly three quarters of the faults that were detected in the system's next releases.
Enterocin 96, a Novel Class II Bacteriocin Produced by <i>Enterococcus faecalis</i> WHE 96, Isolated from Munster Cheese (2009)

Enterococcus faecalis WHE 96, a strain isolated from soft cheese based on its anti-Listeria activity, produced a 5,494-Da bacteriocin that was purified to homogeneity by ultrafiltration and cation-exchange and reversed-phase chromatographies. The amino acid sequence of this bacteriocin, named enterocin 96, was determined by Edman degradation, and its structural gene was sequenced, revealing a double-glycine leader peptide. After a comparison with other bacteriocins, it was shown that enterocin 96 was a new class II bacteriocin that showed very little similarity with known structures. Enterocin 96 was indeed a new bacteriocin belonging to class II bacteriocins. The activity spectrum of enterocin 96 covered a wide range of bacteria, with strong activity against most gram-positive strains but very little or no activity against gram-negative strains.
Functionally based augmented sculpting (2005)

In this paper we describe an approach to computer-aided sculpting concerned with the creation and modification of digital models based on physical abstract sculptures. We begin by presenting a survey of current methods for the creation of computer-aided sculptured artefacts. Then we proceed to present some original methods and tools based on the function representation of geometric models. We introduce a specialized computer language, named HyperFun, which facilitates the modelling of complex objects. As well as presenting computer-generated animated models of pre-existing sculptures by Russian artist Igor Seleznev, we also show how some interesting novel shapes can be generated using the HyperFun system. Finally we outline two advanced projects concerned with creating a sculpture-based augmented reality which allows for the interactive participation of the observer. In this paper, we present experimental results, which hopefully have some artistic appeal. These results were produced by an international team of researchers and students collaborating through the Internet. Copyright © 2005 John Wiley & Sons, Ltd.
Application-specific benchmarking (2001)

This thesis introduces a novel approach to performance evaluation, called application-specific benchmarking, and presents techniques for designing and constructing meaningful benchmarks. 
A traditional benchmark usually includes a fixed set of programs that are run on different systems to produce a single figure of merit, which is then used to rank system performance. This approach often overlooks the relevance between the benchmark programs and the real applications they are supposed to represent. When the behavior of the benchmark programs do not match those of the intended application, the benchmark scores are uninformative, and sometimes can be misleading. Furthermore, with the rapid pace of application development, it is impractical to create a new standard benchmark whenever a new “killer” application emerges. 
The application-specific benchmarking approach incorporates characteristics of the application of interest into the benchmarking process, yielding performance metrics that reflect the expected behavior of a particular application across a range of different platforms. It also allows benchmarks to evolve with applications and consequently the benchmarks are always up-to-date. 
This thesis applies the application-specific benchmarking methodology to a variety of domains covering Java Virtual Machines, garbage collection, and operating system. The result is a collection of benchmark suites that comprise the HBench framework, including HBench:Java, HBench:JGC, and HBench:OS. 
This thesis demonstrates HBench's superiority in predicting application performance over a more conventional benchmarking approach. It is shown that HBench:Java is able to correctly predict the rank of running times of three commercial applications on a variety of Java Virtual Machine implementations. In the realm of garbage collection, the predicted garbage collection times for a stop-the-world, mark-sweep garbage collector closely match the actual times. In the domain of operating system, it is demonstrated that HBench:OS can be used to analyze performance bottlenecks and to predict performance gains resulting from a common optimization.
TREATMENT OPTIONS FOR PATIENTS WITH RECURRENT OVARIAN CANCER：A REVIEW OF 54 CASES (2006)

客观：与周期性的卵巢的癌症为病人评估治疗选择的功效。方法：从 1990 ～ 2000，有首先在北京联合医学院医院里治疗的周期性的卵巢的癌症的 54 个病人被选择并且考察。与再发性瘤有关的所有临床的数据是镇定的。为在幸存的差别的二方面的 P 价值被艇长回归模型计算。结果：6 个月和外科由抢救化疗跟随了的没有铂的间隔 > 与周期性的卵巢的癌症延长了病人的生存时间(95% CI = 0.153-0.987， P = 0.047；95% CI = 1.611-10.914， P = 0.003，分别地) 。化疗的增加的数字骑车(> 10 个月) 提供的一些在幸存上受益(95% CI = 0.110-1.090， P = 0.070 ) 。治疗和化疗军团的开始没能在幸存表明改进。结论：为有周期性的卵巢的癌症的病人的治疗选择取决于病人的 platinum-free-interval。抢救化疗跟随的第二等的外科的 cytoreduction 的策略与铂敏感的疾病为病人被建议。
Study and design of stability in GH5 cellulases (2011)

Thermostable enzymes that hydrolyze lignocellulosic materials provide potential advantages in process configuration and enhancement of production efficiency over their mesophilic counterparts in the bioethanol industry. In this study, the dynamics of β-1,4-endoglucanases (EC: 3.2.1.4) from family 5 of glycoside hydrolases (GH5) were investigated computationally. The conformational flexibility of 12 GH5 cellulases, ranging from psychrophilic to hyperthermophilic, was investigated by molecular dynamics (MD) simulations at elevated temperatures. The results indicated that the protein flexibility and optimum activity temperatures are appreciably correlated. Intra-protein interactions, packing density and solvent accessible area were further examined in crystal structures to investigate factors that are possibly involved in higher rigidity of thermostable cellulases. The MD simulations and the rules learned from analyses of stabilizing factors were used in design of mutations toward the thermostabilization of cellulase C, one of the GH5 endoglucanases. This enzyme was successfully stabilized both chemically and thermally by introduction of a new disulfide cross-link to its highly mobile 56-amino acid subdomain.
Benzoylformic Acid from Styrene (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzoylformic Acid from StyreneCharles D. Hurd, R. W. McNamee, and Frank O. GreenCite this: J. Am. Chem. Soc. 1939, 61, 10, 2979–2980Publication Date (Print):October 1, 1939Publication History Published online1 May 2002Published inissue 1 October 1939https://pubs.acs.org/doi/10.1021/ja01265a511https://doi.org/10.1021/ja01265a511research-articleACS PublicationsRequest reuse permissionsArticle Views387Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Remarks on the Method of Paired Comparisons: I. The Least Squares Solution Assuming Equal Standard Deviations and Equal Correlations (1951)

Thurstone's Case V of the method of paired comparisons assumes equal standard deviations of sensations corresponding to stimuli and zero correlations between pairs of stimuli sensations. It is shown that the assumption of zero correlations can be relaxed to an assumption of equal correlations between pairs with no change in method. Further the usual approach to the method of paired comparisons Case V is shown to lead to a least squares estimate of the stimulus positions on the sensation scale.