gebhart/patrepeval huggingface dataset:
Spatial data cube: provides better support for spatial data mining (2005)

Spatial data mining is a promising technique that deals with extraction of implicit knowledge or other interesting patterns from large amount of spatial data. Though most data mining systems work with data stored in flat files or operational database, it has been recognized that mining in a data warehouse usually result in better information. Because data are usually cleansed before they are stored into data warehouse. Furthermore, data warehouse provides data with different levels of summarization for the clients, which will lead to fruitful data mining. However, current techniques of data warehouse can not handle spatial data well. Both dimensions and measures in the data model of data warehouse are nonspatial data. In this paper, we propose a new data model called spatial data cube for data warehouse. Spatial data cube supports both spatial and nonspatial data. We also introduce how to construct a spatial data cube that can answer queries efficiently by selective materialization. We believe that the spatial data cube can provide better support for spatial data mining.
Expression of Mast Cell Tryptase in the Chronic Otitis Media with Effusion (2002)

Mast cells are localized in the middle ear and Eustachian tube. They play a prominent role in the inflammatory and allergic conditions. The purpose of this study is to investigate if different inflammatory reactions depend on whether patients are allergic or not by measuring concentration of the mast cell tryptase that reflects the mast cell activity. Materials and Method：Twenty-five patients with chronic otitis media with effusion (COME) were studied. Thirteen patients were confirmed allergy positive by multiallergosorbent test. Mast cell tryptase in the middle ear effusions was measured using western blotting. Results：Mast cell tryptase was more strongly expressed in the effusions with allergy positive than in the allergy negative (p
Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation (2013)

Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes β-catenin (CTNNB1). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of β-catenin and E-cadherin was specifically observed in the tumor cells. Further, the tumor cells were shown to harbor a missense mutation in exon 3 of CTNNB1. We also present a review of the literature describing the clustering of CTNNB1 mutations in patients with SPN.
L'analyse krigeante pour le classement d'observations spatiales et multivariées (2001)

Lorsque l'ingénieur, le chercheur ... désire classer des observations multivariées, un certain nombre de méthodes statistiques sont mises à sa disposition. Lorsque, en outre, les observations sont disposées dans un espace géographique et que l'information spatiale est riche de sens et doit donc être prise en compte, les méthodes adéquates sont beaucoup moins nombreuses. L'article propose une méthodologie d'analyse pour obtenir des groupes de sites ayant les mêmes caractéristiques. Basée sur les techniques d'analyses de données et de géostatistique elle permet également à l'utilisateur de choisir le niveau de perception (échelle) pour le classement.
Arthropod Silks: The Problem of Fibrous Proteins in Animal Tissues (1971)

With a growing world population and increasingly demanding consumers, the production of sufficient protein from livestock, poultry, and fish represents a serious challenge for the future. Approximately 1,900 insect species are eaten worldwide, mainly in ...Read More
Arrayed hybrid filter/coupler device for inservice fibre line testing (1993)

An arrayed hybrid filter/coupler consisting of four waveguide-type wavelength-insensitive couplers and a thin dielectric filter has been developed for application to an in-service optical fibre testing system. The device was designed to combine a 1.31 μm communication light and a 1.55 μm test light with a ratio of 80:20%. The measured performance of a prototype device exhibited an excess loss of 0.6 dB, a return loss attenuation of >45dB and a crosstalk attenuation for the test light of >60dB.
Patient Rating of Wrist Pain and Disability: A Reliable and Valid Measurement Tool (1998)

The PRWE provides a brief, reliable, and valid measure of patient-rated pain and disability.
A Grouped Fast Fourier Transform Algorithm Design For Selective Transformed Outputs (2006)

In this paper, the grouped scheme is specially applied to compute the fast Fourier transform (FFT) when the portions of transformed outputs are calculated selectively. The grouped FFT algorithm applies the scheme of the grouped frequency indices to accelerate the computation of selected DFT outputs. The advantage of the grouped FFT algorithm is that it is more cost-effective than the convenient FFT algorithms when the authors need to compute parts of the transformed outputs, not all outputs. For computing all transformed outputs of the DFT, the computational complexity of the proposed FFT method is less than that of the radix-2 method. Meanwhile, the computational complexity of the proposed fast method approximates to that of the radix-4 FFT algorithm. By sharing coefficients of the twiddle factors in the same frequency group, the grouped FFT can be implemented with hardware sharing VLSI architectures
Pharmacogenetics of Warfarin (2009)

Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability in dose requirement. Because it is difficult to predict an accurate dose for an individual, patients starting the drug are at risk of thromboembolism or bleeding associated with underdosing or overdosing, respectively. Single nucleotide polymorphisms in the cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKOR) genes have been shown to have a significant effect on warfarin dose requirement. Other genes mediating the action of warfarin make either little or no contribution to dose requirement. Although the polymorphisms in CYP2C9 and VKORC1 explain a significant proportion of the interindividual variability in warfarin dose requirement, currently available evidence based on a few small studies relating to the use of pharmacogenetics-guided dosing in the initiation of warfarin therapy has not shown improved outcomes in either safety or efficacy of therapy. Better clinical evidence of beneficial effects on patient outcome, particularly at the extremes of the dose requirements in geographically and ethnically diverse patient populations, is needed before the role of a pharmacogenomic approach to oral anticoagulation therapy in clinical practice can be established.
Mixed-membership models of scientific publications (2004)

PNAS is one of world's most cited multidisciplinary scientific journals. The PNAS official classification structure of subjects is reflected in topic labels submitted by the authors of articles, largely related to traditionally established disciplines. These include broad field classifications into physical sciences, biological sciences, social sciences, and further subtopic classifications within the fields. Focusing on biological sciences, we explore an internal soft-classification structure of articles based only on semantic decompositions of abstracts and bibliographies and compare it with the formal discipline classifications. Our model assumes that there is a fixed number of internal categories, each characterized by multinomial distributions over words (in abstracts) and references (in bibliographies). Soft classification for each article is based on proportions of the article's content coming from each category. We discuss the appropriateness of the model for the PNAS database as well as other features of the data relevant to soft classification.
Receptor dimerization: a key step in chemokine signaling. (2001)

Chemokines exert their effects through their interaction with seven transmembrane domain receptors coupled to G-proteins, GPCRs. Such receptor ligation leads to the regulation of numerous activities where chemokines play a key role, including hematopoiesis, T-cell activation, angiogenesis, inflammatory diseases or HIV-1 infection. Here we discuss the molecular mechanisms that underlie chemokine receptor activation. As occurs with other GPCRs, chemokines initiate the signaling cascades by inducing receptor dimerization. This dimerization enables the activation of the JAK/STAT pathway which allows the subsequent triggering of G-protein dependent signaling events. This mechanism provides a new context to explain some of the activities exerted by chemokines and introduces new targets for the development of drugs to fight those diseases were chemokines are implicated, such as inflammation and AIDS.
Mono(fluoro-olefin) complexes of pentacarbonyliron (1967)

R. Fields, M. M. Germain, R. N. Haszeldine and P. W. Wiggans, Chem. Commun. (London), 1967, 243 DOI: 10.1039/C19670000243
Hyperglycemia during the Immediate Period after Kidney Transplantation (2009)

Investigators have historically attempted to identify hyperglycemia after hospital discharge. Our data indicate that a substantial number of patients without pretransplantation diabetes develop hyperglycemia and require insulin during the hospital phase of their care immediately after kidney transplantation. Prospective studies are needed to delineate factors that contribute to development of new-onset diabetes after transplantation among patients with transient hyperglycemia.
Pyrazole/imidazole and pyrazolato/imidazolato complexes of pentacyanoferrate(II/III) and pentaammineruthenium(II/III). LMCT transitions of low-spin d5 complexes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazole/imidazole and pyrazolato/imidazolato complexes of pentacyanoferrate(II/III) and pentaammineruthenium(II/III). LMCT transitions of low-spin d5 complexesCraig R. Johnson, Wayne W. Henderson, and Rex E. ShepherdCite this: Inorg. Chem. 1984, 23, 18, 2754–2763Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ic00186a009https://doi.org/10.1021/ic00186a009research-articleACS PublicationsRequest reuse permissionsArticle Views794Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complete nucleotide sequence coding for rat liver 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase derived from a cDNA clone (1987)

cDNA clones for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase were isolated from rat liver expression libraries in lambda gt11 by antibody, oligonucleotide, and cDNA screening. One 1860 bp long clone contained a full-length nucleotide sequence coding for the 470 amino acids of each of the two identical subunits of the bifunctional enzyme. This clone also contained untranslated sequences, one 173 bp long upstream from the ATG start codon and one 271 bp long downstream from the TGA stop codon. The clone was terminated by a poly(A) tail of 29 nucleotides.
Life-Cycle Saving and Bequest Behavior (1978)

The motive of saving to finance a stable level of future consumption expenditures has been given virtually exclusive emphasis in recent life-cycle and permanent income models of saving behavior. The present article argues that Fisherian models of optimal consumption and saving do not provide a good description of actual aggregate, private saving behavior. While life-cycle motives may characterize the savings behavior of the overwhelming majority of the working population, they do not provide a satisfactory explanation of the behavior of the top wealth holders, who account for a preponderant share of total private saving. Neoclassical models, which treat saving behavior as homogeneous, neglect the important systematic relationships observed in differential saving targets for bequest purposes out of labor and property income. In addition, the evidence suggests that assets themselves belong in the utility function of wealth owners. The quantitative significance of bequests indicates that a large part of wealth accumulation in capitalist economies is the result of motives other than the desire to defer present consumption to the future. The implications of the argument lead toward the rejection, or at least a fundamental reappraisal, of neoclassical rationality models based on intertemporal utility optimization as an explanation of aggregate saving behavior. Economists must look elsewhere if they are to account successfully for the observed saving behavior of the very wealthy.
Pre-analytical Conditions Affecting the Determination of the Plasma Homocysteine Concentration (2001)

In the past decade, moderately elevated homocysteine concentration has achieved wide-spread recognition as an independent risk factor for vascular diseases, such as stroke and peripheral vascular disease, as well as for an impaired nutritional status. In general, EDTA plasma is used for the determination of homocysteine. However, from the pre-analytical point of view it is important, that, when plasma is not separated from blood cells within 30 minutes, homocysteine levels increase in samples significantly by about 10% per hour. This 10% increase is very important, because the normal range is between 5 and 15 micromol/l and moderately elevated homocysteine concentrations above 15 micromol/l may signify an increased risk of vascular disease. These preliminary cut-off points show that there is only a small difference between normal and moderately elevated homocysteine concentrations. Most blood samples are obtained outside the hospital, and in these cases homocysteine concentrations will be falsely elevated, if no precautions are taken, such as immediate centrifugation and separation of plasma and cells. This aspect is critical both for clinical studies and in patient care outside the hospital. But even in the hospital it is difficult to separate plasma and cells within 30 minutes. In the past, different approaches were adopted to solve this problem. Potential stabilisers were sodium fluoride (4 g/l) and 3-deazaadenosine (100 micromol/l). Sodium fluoride initially increased the homocysteine concentration, which dropped below the initial values after 72 h. On the other hand, 3-deazaadenosine stabilised homocysteine concentrations for 24 h, but increased it within 72 h by roughly 10%. However, this stabiliser is restricted to HPLC technology but does not work reliably with immunoassays. Lysis of blood stabilised homocysteine, but homocysteine concentrations were systematically lower requiring totally new reference ranges. In addition, acidic citrate (0.5 mol/l) was evaluated, which seems to stabilise plasma homocysteine concentrations at ambient temperatures for several hours. However, small but systematic deviations at baseline are observed. This stabilisation procedure does not interfere with immunoassays. Because immunoassays will be the future method of choice for robust and easy to perform homocysteine measurements, because they easily allow the analyses of high sample numbers, homocysteine stabilisation in whole blood is still an important matter. It must be solved before homocysteine determinations are introduced as a general screening for vascular risk factors in non-specialist laboratories.
The Recognition of Handwritten Numerals by Contour Analysis (1963)

A character recognition system has been developed for the recognition of handwritten numerals. This system uses a logically controlled cathode ray tube scanner to generate basic measurements that characterize significant features of the numeral shapes. A contour-follower procedure is used to control the scanner. In addition, special scanner subroutines initiated by feedback from the recognition logic are utilized. Character shape data are generated in a sequential form, which can be analyzed for recognition with an easily realizable logic. An experimental model has been built that recognized 99.3% of numerals written by 45 subjects after 30 minutes of training. The error rate for these characters was 0.11%. The rejected character rate was 0.59%.
Side-Chain Jacketed Liquid Crystalline Polymer Forming Double-Chain Supramolecular Column and Hexagonal Superlattice (2018)

We synthesized a series of poly(dialkyl 1-viny-3,5-isophthalate) (P3,5-n, n is the number of carbons on alkyl group, n = 4–18), wherein the polyethylene backbone is jacketed by the isophthalate side chains. The phase behaviors of P3,5-n were investigated by using various techniques including thermal analysis, polarized light microscopy, and X-ray diffraction. It is identified that with n ≥ 8 the P3,5-n samples form the hexagonal columnar phase (ΦH). Furthermore, P3,5-16 and P3,5-18 can exhibit a four-column hexagonal superlattice (ΦHS), wherein one column is frustrated. After the alkyl tails are fully melted or crystallized, the ΦHS degrades into the conventional ΦH phase. For the ΦH of P3,5-n observed, the cross section area of the column (S) increases linearly with n, S = 1.97 + 0.52n (nm2). The number of repeating units (Zrep) required to be packed in the 0.44 nm thick column stratum is 4. Compared with poly(dialkyl 1-vinyl-2,5-terephthalate) (P2,5-n), which is the isomer of P3,5-n and can form the ΦH phase based on the parallel packing of a “single-chain column”, P3,5-n possesses the intercept and slope of the linear function of S vs n and the Zrep value nearly twice that found for P2,5-n. We propose that P3,5-n can self-organize into the column containing two chains laterally associated together. Namely, P3,5-n takes the “double-chain column” rather than the “single-chain column” as the building block for the ΦH phase.
A rolling circle replication initiator protein with a nucleotidyl‐transferase activity encoded by the plasmid pGT5 from the hyperthermophilic archaeon <i>Pyrococcus abyssi</i> (1998)

The plasmid pGT5 from the hyperthermophilic archaeon Pyrococcus abyssi presents similarities to plasmids from the pC194 family that replicate by the rolling circle mechanism. These plasmids encode a replication initiator protein, which activates the replication origin by nicking one of the two DNA strands. The gene encoding the putative Rep protein of pGT5 (Rep75) has been cloned and overexpressed in Escherichia coli, and the recombinant protein has been purified to homogeneity. Rep75 exhibits a highly thermophilic nicking-closing activity in vitro on single-stranded oligonucleotides containing the putative double-stranded replication origin sequence of pGT5. Gel shift analyses on single-stranded oligonucleotides indicate that Rep75 recognizes the single-stranded DNA region upstream of the nicking site via non-covalent interaction and remains covalently linked to the 5'-phosphate of the downstream fragment after nicking. Besides these expected activities, Rep75 contains a dATP (and ATP) terminal transferase activity at the 3'-OH extremity of the nicking site, which had not been reported previously for proteins of this type. Rep75, which is the first replication initiator protein characterized in an archaeon, offers an attractive new model for the study of rolling circle replication.
UAV 3D mapping with RGB-D camera (2017)

In this article, we focus on how to fuse two systems between SLAM and UAV. The main contribution is that using the UAV attitude controller provides a reliable initial value for the SLAM system, which makes the direct method of SLAM more quickly and effective converge. The UAV position controller increases the stability by receiving the exact local information from SLAM. That allows two independent systems to promote each other. Finally, we design relevant experiments to verify the feasibility of this method. We verify the idea with a good response to the rapid rotation of the camera.
Phase-locked loop with neurocontroller (2002)

For a large phase difference between carrier input and the output of VCO (voltage controlled oscillator) of PLL (phase lock loop), highly nonlinear and periodic characteristics are imposed on the phase detector. Loss tracking arises. A method using an energy detector and a back-propagation neural network as controller in PLL is proposed to solve the problem. In this approach, the frequencies of the carrier input and VCO are acquired by energy detector, and the frequency-tracking is achieved by the neurocontroller. When the frequencies are tracked, the phase error will be eliminated by PLL. According to the result of simulation, this approach can not only track varying frequencies of carrier input, but also can quickly lock the phase.
Fast, local signal transduction between the mu opioid receptor and Ca2+ channels (1995)

We used patch-clamp methods to describe signal transduction between the mu opioid receptor, the binding site for morphine, and high-threshold Ca2+ channels in dorsal root ganglion (DRG) sensory neurons from adult rats. Opioid signaling persists in excised membrane patches, and an activated opioid receptor can only inhibit nearby Ca2+ channels; thus, no readily diffusible second-messenger molecule mediates between the mu receptor and Ca2+ channels. Inhibition of Ca2+ channels begins several hundred msec after application of opioid and it is maximal by 5 sec; this is faster than typical phosphorylation cascades. Blockade of the known serine-threonine kinases and phosphatases does not affect this opioid signaling and, as shown previously by Seward et al. (1991) and Moises et al. (1994a), pertussis toxin eliminates virtually all of the effect. Inhibited channels can open, but their half-activation voltage is unphysiologically positive. The link between the mu receptor and Ca2+ channels is clearly unlike the protein kinase C-dependent paths that couple mu receptors to NMDA channels in dorsal horn neurons (Chen and Huang, 1991) and alpha-adrenergic receptors to Ca2+ channels in DRG neurons (Diversé-Pierluissi and Dunlap, 1993). The rapid kinetics and tight localization of the signaling path are properties expected if receptor and channel are linked directly by a G-protein, but these properties do not constitute proof of such a pathway.