gebhart/patrepeval huggingface dataset:
Continuous scanning laser doppler vibrometry for synchronized array measurements: applications to non-contact sensing of human body vibrations (2012)

Laser Doppler Vibrometry (LDV) is a non-contact technique for sensing surface vibrations. Traditionally, LDV uses one or more fixed beams to measure the vibrational velocity of specific points and orientations. In order to measure an angular velocity at least two laser beams are required. Instead, this research proposes to develop a Continuous Scanning Laser Doppler Vibrometer (CSLDV) technique, based on a single laser beam continuously sweeping the area of interest using a scanning mirror. Linear scans allow the measurement of normal and angular velocity while circular scans allow the measurement of normal velocity and two angular velocities. The first part of the study analyzes the performance of rigid body models of both the short line and circular scans (< 1 cm) for measuring low broadband frequency vibrations of gel samples. This thesis focused on low frequency broadband vibration since natural human body vibrations (such as tremor or breathing) are typically below a few hundred hertz. Results for normal and angular velocity measurements are validated against conventional method of using two fixed LDVs. The second part of this research investigates the CSLDV technique for longer scans (< 5 cm). These long scans will be used to act as an array of virtual transducers at multiple points along the scanning path of the single laser beam; thus yielding similar information obtained using an array of several real fixed LDVs. A practical challenge encountered when using CSLDV is speckle noise, that is generated when a coherent light source is reflected back from an optically rough surface. The effect of speckle noise will be quantified by varying different parameters such as scan lengths, scanning frequency, target to sensor distance and the amplitude of excitation. These parameters will be optimized in order to reduce the error of vibration measurements obtained from the CSLDV. Such systems will be used to monitor multiple degrees of freedom of human skeletal muscle vibrations for elastography purposes. The forced vibration of human muscles will be analyzed using these CSLDV techniques.\nOverall contributions of this work include: (1) Validation of rigid body models of both short line and circular scans CSLDV for broadband low frequency linear and angular velocity measurements; (2) application to sensing natural human body vibrations (e.g., hand tremors); (3) replacement of an array of vibration sensors by a single long line scan CSLDV. (4) development of a dynamic elastography technique for skeletal muscles using CSLDV.
Drone were me: Flying drone as avatar by aligned stereo view and head pose (2016)

In this paper, we present a natural interface between a drone, i.e., a miniature aerial vehicle (MAV), and a human, in which a stereo-vision-MAV is flied via a HMD (Head Mounted Display) with inertial sensors. A stereo camera is mounted on a MAV and the stereo images are transmitted to a remote PC. Then, a user controls the motion of the MAV by his/her head pose, which is measured from the inertial sensor of the HMD, while looking at the stereo images via the HMD as if the MAV is an avatar of the user. Thanks to a stereo-vision camera, it makes it possible that not only a user can sense the distance information between the MAV and obstacles from the HMD, but also a MAV can avoid collisions using the measured 3D information even if human error occurs during the operation.
Regulation of<i>Staphylococcus aureus</i>α‐Toxin Gene<i>(hla)</i>Expression by<i>agr, sarA,</i>and<i>sae</i>In Vitro and in Experimental Infective Endocarditis (2006)

These results indicate that, although several distinct regulatory circuits can affect hla expression in vitro and in vivo, sae appears to play a crucial role in this context.
Square-planar transitioin metal complexes with tetradentate thioiminato Schiff base ligands (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSquare-planar transitioin metal complexes with tetradentate thioiminato Schiff base ligandsPatricia R. Blum, Richard M. C. Wei, and Sue C. CummingsCite this: Inorg. Chem. 1974, 13, 2, 450–456Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://pubs.acs.org/doi/10.1021/ic50132a044https://doi.org/10.1021/ic50132a044research-articleACS PublicationsRequest reuse permissionsArticle Views593Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photoreactions of succinimides with an N-acyl group in the side chain. Synthesis and stereochemistry of tricyclic pyrrolo(1,2-a)pyrazine ring systems. (1986)

Photocyclization of succinimides with an N-acyl group in the side chain gave bi- and tricyclic phyrrolo[1, 2-a]pyrazines, some of which were converted to tricyclic amines by reduction. The stereochemistry of pyrrolo[1, 2-a]pyrazine derivatives is discussed on the basis of the results of X-ray analysis and carbon-13 nuclear magnetic resonance spectroscopy.
Early Detection of Pseudomonas Burn Infection (1969)

After more than three years experience with improved topical therapy for major thermal wounds,<sup>1,2</sup>it is apparent that wound infection remains a significant threat to burned man. Although the frequency of burn wound sepsis and death therefrom has been much reduced and survival significantly improved, infection by<i>Pseudomonas aeruginosa</i>continues to cause more deaths than any other complication when careful bacteriologic and autopsy examinations are regularly done.<sup>3</sup> The careful studies of Brentano et al<sup>4</sup>indicated that increasing numbers of bacteria were elaborated from the burn wound concomitant with clinical invasive sepsis. Studies undertaken with a simpler technique for serial quantitative bacteriologic assay of the burn wound indicated that significant increases in bacterial wound density preceded invasive infection as well as all clinical signs thereof.<sup>5</sup>It was surmised and subsequently confirmed, that prompt detection of such increased bacterial density might allow earlier diagnosis of burn wound infection,
Beat estimation on the beat (2004)

The paper presents a novel method for the estimation of beat interval, and the exact location of the beats, from audio files. As a first step, a feature extracted from the waveform is used to identify note onsets. The estimated note onsets are used as input to a beat induction algorithm, where the most probable beat intervals are found. The note onsets corresponding to the beat locations are then identified. Several enhancements are proposed, including methods for identifying the optimum audio feature, a novel weighting system in the beat induction algorithm and a simple robust method for identifying the beat locations. The resulting system runs in real-time, and is shown to work well for a wide variety of contemporary and popular rhythmic music.
GeoSTAR: a microwave sounder for geostationary applications (2006)

The Geostationary Synthetic Thinned Aperture Radiometer, GeoSTAR, is a new concept for a microwave atmospheric sounder intended for geostationary satellites such as the GOES weather satellites operated by NOAA. A small but fully functional prototype has recently been developed at the Jet Propulsion Laboratory to demonstrate the feasibility of using aperture synthesis in lieu of the large solid parabolic dish antenna that is required with the conventional approach. Spatial resolution requirements dictate such a large aperture in GEO that the conventional approach has not been feasible, and it is only now, with the GeoSTAR approach, that a GEO microwave sounder can be contemplated. Others have proposed GEO microwave radiometers that would operate at sub-millimeter wavelengths to circumvent the large-aperture problem, but GeoSTAR is the only viable approach that can provide full sounding capabilities equal to or exceeding those of the AMSU systems now operating on LEO weather satellites and which have had tremendous impact on numerical weather forecasting. GeoSTAR will satisfy a number of important measurement objectives, many of them identified by NOAA as unmet needs in their GOES-R pre-planned product improvements (P3I) lists and others by NASA in their research roadmaps and as discussed in a white paper submitted to the NRC Decadal Survey. The performance of the prototype has been outstanding, and this proof of concept represents a major breakthrough in remote sensing capabilities. The GeoSTAR concept is now at a stage of development where an infusion into space systems can be initiated, either on a NASA sponsored research mission or on a NOAA sponsored operational mission. GeoSTAR is an ideal candidate for a joint "research to operations" mission, and that may be the most likely scenario. Additional GeoSTAR related technology development and other risk reduction activities are under way, and a GeoSTAR mission is feasible in the GOES-R/S time frame, 2012-2014.
Learning a Domain-Invariant Embedding for Unsupervised Domain Adaptation Using Class-Conditioned Distribution Alignment (2019)

We address the problem of unsupervised domain adaptation (UDA) by learning a cross-domain agnostic embedding space, where the distance between the probability distributions of the two source and target visual domains is minimized. We use the output space of a shared cross-domain deep encoder to model the embedding space anduse the Sliced-Wasserstein Distance (SWD) to measure and minimize the distance between the embedded distributions of two source and target domains to enforce the embedding to be domain-agnostic.Additionally, we use the source domain labeled data to train a deep classifier from the embedding space to the label space to enforce the embedding space to be discriminative.As a result of this training scheme, we provide an effective solution to train the deep classification network on the source domain such that it will generalize well on the target domain, where only unlabeled training data is accessible. To mitigate the challenge of class matching, we also align corresponding classes in the embedding space by using high confidence pseudo-labels for the target domain, i.e. assigning the class for which the source classifier has a high prediction probability. We provide experimental results on UDA benchmark tasks to demonstrate that our method is effective and leads to state-of-the-art performance.
Multiple photon excited SF6 interaction with silicon surfaces (1981)

Infrared laser induced SF6–silicon interactions have been studied and the surface reaction yields have been determined as a function of the laser frequency, the laser intensity, and the gas pressure in both perpendicular and parallel beam incidences on the solid surfaces. The results clearly show that vibrationally excited SF6 molecules promoted by CO2 laser pulses are very reactive to silicon, particularly when the solid is simultaneously exposed to the intense ir radiation. The laser excitation of the Si substrate alone cannot cause the heterogeneous reaction to occur. The present gas–solid system thus provides an example which clearly establishes the direct correlation between surface reactivity and vibrational activation. Additional experimental measurements also demonstrate that the thermal fluorine atoms generated by SF6 multiple photon dissociation at high laser intensities can react with silicon to form volatile product. The study thus provides further insight into the silicon–fluorine reaction dynamics.
Effect of oxygen fluctuations on recombinant <i>Escherichia coli</i> fermentation (1993)

Escherichia coli DH5alpha, carrying the pUC19 plasmid for the lacZ fragment of beta-galactosidase and ampicillin resistance, was grown in a batch fermentor under conditions of fluctuating oxygen supply. A Monte Carlo method was used to control the on/off supply of air to simulate circulation of cells in a large fermentor. Rapid changes in oxygen supply reduced the rates of oxygen uptake the carbon dioxide release and prolonged the active second growth phase in batch culture, compared to growth with continuous aeration. Amplification of the plasmid was observed during the stationary phase when air supplied continuously, but not during the Monte Carlo experiments.
Maintenance Fluconazole Therapy for Recurrent Vulvovaginal Candidiasis (2004)

Long-term weekly treatment with fluconazole can reduce the rate of recurrence of symptomatic vulvovaginal candidiasis. However, a long-term cure remains difficult to achieve.
Polymethylmethacrylate Microspheres/Collagen as a Tissue Augmenting Agent (2005)

When polymethylmethacrylate microspheres/collagen is introduced to the United States, practitioners will need to learn how to use this exacting agent and will obtain excellent results with careful use.
A novel electroluminescent diode with nanocrystalline silicon quantum dots (2002)

We have developed an electroluminescent (EL) diode with novel active layers of nanocrystalline silicon (Si) quantum dots. The nanocrystalline Si active layer is fabricated by pulsed laser ablation (PLA) in inert gas ambient. The structure of the EL diodes is semitransparent Pt electrode/silicon nanocrystallite layer/p-type Si/Pt electrode. We have observed visible spectra of not only photoluminescence (PL) around 2.10 eV but also EL around 1.65 eV, at room temperature. The EL diodes show a rectifying behavior. Furthermore, we have found that the EL diodes show strong nonlinear dependence of EL intensity on current density. A possible mechanism of this emission is impact ionization by hot electrons injected through the surface oxide layers and successive radiative recombination.
A 2-GHz carrier leakage calibrated direct-conversion WCDMA transmitter in 0.13-/spl mu/m CMOS (2004)

A highly integrated 2-GHz, 0.13-/spl mu/m CMOS direct-conversion transmitter for wide-band code division multiple access (WCDMA) is described. Different circuit and calibration techniques are presented that successfully suppress the carrier leakage and enable the direct-upconversion architecture to meet all WCDMA specifications. The transmitter delivers +2.5 dBm output power while consuming only 45 mA from its nominal 1.5-V supply. The overall gain can be programmed in 1-dB steps over a 100-dB range with 0.4 dB accuracy. The transmitter achieves an OIP3 of +19.3 dBm, an error vector magnitude of 4.3%, and an adjacent channel leakage ratio of -38 dBc. The measured output noise of -146 dBm/Hz in the DCS Rx band and -149 dBm/Hz in the UMTS Rx band is sufficiently low to provide an option to increase the integration level even further by eliminating the external Tx interstage filter between the power amplifier and its driver.
Placenta-derived extracellular vesicles induce preeclampsia in mouse models (2019)

Preeclampsia is a pregnancy-induced condition that impairs the mother's health and results in pregnancy termination or premature delivery. Elevated levels of placenta-derived extracellular vesicles (pcEV) in the circulation have been consistently associated with preeclampsia, but whether these vesicles induce preeclampsia or are the product of preeclampsia is not known. Guided by a small cohort study of preeclamptic patients, we examined the impact of pcEV on the pathogenesis of preeclampsia in mouse models. We detected pcEV in pregnant C56BL/6J mice with a peak level of 3.8±0.9×10<sup>7</sup>/mL at 17-18 days post-coitum. However, these pregnant mice developed hypertension and proteinuria only after being infused with vesicles purified from injured placenta. These extracellular vesicles released from injured placenta disrupted endothelial integrity and induced vasoconstriction. Enhancing the clearance of extracellular vesicles prevented the development of the extracellular vesicle-induced preeclampsia in mice. Our results demonstrate a causal role of pcEV in preeclampsia and identify microvesicle clearance as a new therapeutic strategy for the treatment of this pregnancy-associated complication.
Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment (2009)

Recent evidence shows that a sub-population of Wnt/beta-catenin target genes is specifically induced in different tissue contexts. FZD7 is a putative Wnt/beta-catenin target gene and although it is highly expressed in well-differentiated colorectal cancer tumour cells, its expression is decreased in de-differentiated tumour cells at the invasive front despite elevated Wnt/beta-catenin signalling in this area. This variable expression of FZD7 implicates additional regulation by the microenvironment; however, this has not been investigated. To begin to elucidate the role of extracellular matrix in regulating FZD7 expression, we generated a FZD7 promoter reporter and analysed FZD7 promoter activity in colorectal cancer cells grown on different matrices. We demonstrate that the FZD7 promoter is regulated by beta-catenin in colorectal cancer cells and observed decreased promoter activity in cells grown on fibronectin but not collagen I or collagen IV. Thus, expression of FZD7 in colorectal cancer may be regulated by fibronectin in the microenvironment.
The in vivo role of annexin VII (synexin): characterization of an annexin VII deficient <i>Dictyostelium</i> mutant indicates an involvement in Ca2+-regulated processes (1995)

Dictyostelium discoideum cells harbor two annexin VII isoforms of 47 and 51 kDa which are present throughout development. In immunofluorescence and cell fractionation studies annexin VII was found in the cytoplasm and on the plasma membrane. In gene disruption mutants lacking both annexin VII isoforms growth, pinocytosis, phagocytosis, chemotaxis and motility were not significantly impaired under routine laboratory conditions, and the cells were able to complete the developmental cycle on bacterial plates. On non-nutrient agar plates development was delayed by three to four hours and a significant number of aggregates was no longer able to form fruiting bodies. Exocytosis as determined by measuring extracellular cAMP phosphodiesterase, alpha-fucosidase and alpha-mannosidase activity was unaltered, the total amounts of these enzymes were however lower in the mutant than in the wild type. The mutant cells were markedly impaired when they were exposed to low Ca2+ concentrations by adding EGTA to the nutrient medium. Under these conditions growth, motility and chemotaxis were severely affected. The Ca2+ concentrations were similar in mutant and wild-type cells both under normal and Ca2+ limiting conditions; however, the distribution was altered under low Ca2+ conditions in SYN-cells. The data suggest that annexin VII is not required for membrane fusion events but rather contributes to proper Ca2+ homeostasis in the cell.
A vortex transitional memory cell for 1-Mbit/cm/sup 2/ density Josephson RAMs (1997)

We developed an 8.5 /spl mu/m/spl times/11.5 /spl mu/m vortex transitional (VT) memory cell. The memory cell is the smallest Josephson memory cell ever reported. The cell was fabricated by electron cyclotron resonance plasma etching and bias-sputtering planarization. This is also the first Josephson circuit fabricated with sub-micron minimum feature size. Proper nondestructive read-out operation was verified even after half-selected conditions. An operating margin of /spl plusmn/14% was obtained for control currents I/sub X/ and I/sub Y/. These results are promising for developing a 1-Mbit/cm/sup 2/ density Josephson RAM.
Ego-motion estimation and moving object tracking using multi-layer LIDAR (2009)

This paper presents an approach for the robust recognition of a complex and dynamic driving environment, such as an urban area, using on-vehicle multilayer LIDAR. The multilayer LIDAR alleviates the consequences of occlusion by vertical scanning; it can detect objects with different heights simultaneously, and therefore the influence of occlusion can be curbed. The road environment recognition algorithm proposed in this paper consists of three procedures: ego-motion estimation, construction and updating of a 3-dimensional local grid map, and the detection and tracking of moving objects. The integration of these procedures enables us to estimate ego-motion accurately, along with the positions and states of moving objects, the free area where vehicles and pedestrians can move freely, and the dasiaunknownpsila area, which have never previously been observed in a road environment.
PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat (2014)

Histone deacetylase (HDAC) enzymes have been demonstrated as critical components in maintaining chromatin homeostasis, CNS development, and normal brain function. Evidence in mouse models links HDAC expression to learning, memory, and mood-related behaviors; small molecule HDAC inhibitor tool compounds have been used to demonstrate the importance of specific HDAC subtypes in modulating CNS-disease-related behaviors in rodents. So far, no direct evidence exists to understand the quantitative changes in HDAC target engagement that are necessary to alter biochemistry and behavior in a living animal. Understanding the relationship between target engagement and in vivo effect is essential in refining new ways to alleviate disease. We describe here, using positron emission tomography (PET) imaging of rat brain, the in vivo target engagement of a subset of class I/IIb HDAC enzymes implicated in CNS-disease (HDAC subtypes 1, 2, 3, and 6). We found marked differences in the brain penetrance of tool compounds from the hydroxamate and benzamide HDAC inhibitor classes and resolved a novel, highly brain penetrant benzamide, CN147, chronic treatment with which resulted in an antidepressant-like effect in a rat behavioral test. Our work highlights a new translational path for understanding the molecular and behavioral consequences of HDAC target engagement.
Use of Implantable Pumps for Central Nervous System Drug Infusions to Treat Neurological Disease (1988)

Increasing knowledge of the neurochemical aspects of central nervous system function raises the possibility of treating neurological disease by the appropriate manipulation of neurotransmitters, neuromodulators, and neurohormones. Clinical application of this knowledge has been inhibited, however, by long-standing problems with drug delivery to the central nervous system (CNS). The availability of implantable drug infusion pumps and stereotactic catheter placement techniques may overcome many of these problems. The problems of drug delivery to the brain and the present and potential uses of implantable drug pumps for neurological disease are discussed. In addition, the relationship between CNS drug infusion and neural tissue transplantation is briefly reviewed.