gebhart/patrepeval huggingface dataset:
Drug-eluting stents: a reappraisal (2010)

<h3>Background</h3> At 18 weeks duration, University of Limerick — Graduate Entry Medical School (UL–GEMS) has the longest general practice clinical attachment for medical students in Ireland and fulfils the educational criteria for a Longitudinal Integrated Clerkship (LIC).The longer the clinical placement the greater the imperative to see that these practices achieve satisfactory educational standards. <h3>Aim</h3> This project describes a quality assurance initiative of general practices that participate in the education of medical students at GEMS. <h3>Method</h3> A literature review of previous quality assurance initiatives in relation to general practices that teach medical students was performed. Information gained from this process was then compared with UL-GEMS own criteria for teaching general practices. A set of criteria by for assessing teaching general practices was devised. The assessment process included a combination of self-assessment by the GP tutors and practice visits by the UL-GEMS teaching staff. <h3>Results</h3> Nearly 100% of teaching practices had the correct teaching facilities, such as own room for the student or own computer. Suggested teaching methods, such as parallel consulting, as advised by the Department of General Practice were carried by 100% of practices. Use of the two-way feedback form and the GP/Student manual was poor. GP tutors requested more regular visits form the GP teaching staff as well as more guidance on content for formal tutorials so that a consistency teaching approach could be achieved. <h3>Conclusion</h3> This was the first quality assurance initiative on an extended clinical placement. The knowledge gained will lead to a more inclusive standard setting process for teaching medical students in general practice settings.
Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8+ T-cell Responses (2013)

Clinical trials reveal that plasmid DNA (pDNA)-based gene delivery must be improved to realize its potential to treat human disease. Current pDNA platforms suffer from brief transgene expression, primarily due to the spread of transcriptionally repressive chromatin initially deposited on plasmid bacterial backbone sequences. Minicircle (MC) DNA lacks plasmid backbone sequences and correspondingly confers higher levels of sustained transgene expression upon delivery, accounting for its success in preclinical gene therapy models. In this study, we show for the first time that MC DNA also functions as a vaccine platform. We used a luciferase reporter transgene to demonstrate that intradermal delivery of MC DNA, relative to pDNA, resulted in significantly higher and persistent levels of luciferase expression in mouse skin. Next, we immunized mice intradermally with DNA encoding a peptide that, when presented by the appropriate major histocompatibility complex class I molecule, was recognized by endogenous CD8(+) T cells. Finally, immunization with peptide-encoding MC DNA, but not the corresponding full-length (FL) pDNA, conferred significant protection in mice challenged with Listeria monocytogenes expressing the model peptide. Together, our results suggest intradermal delivery of MC DNA may prove more efficacious for prophylaxis than traditional pDNA vaccines.
System in package with mounted capacitor for reduced parasitic inductance in voltage regulators (2008)

A system in package (SiP) on which an input capacitor is mounted has been developed for voltage regulators. The SiP offers the world's lowest power dissipation of 3.8 W at 1 MHz. Its parasitic inductance is 44% lower than SiPs with the input capacitor mounted on the PCB, due to a small loop from the input capacitor to the MOSFETs, which reduces power dissipation by 25% at the same peak voltage. The high-side MOSFET die is flipped so that the drain electrode faces up, facilitating the connection of the MOSFET to the input capacitor. The lead frames and MOSFETs are connected with Cu leads, which reduce the spreading resistance of the MOSFET electrodes.
Kinetics of residual stress evolution in evaporated silicon dioxide films exposed to room air (1996)

Deposition of silicon dioxide thin films on silicon, germanium, and glass substrates has been accomplished by electron gun evaporation under various experimental conditions. The level of compressive residual stresses in evaporated SiO2 films determined just after deposition of films on Si or Ge substrates and the mass density of silica were found to be dependent on the substrate temperature and oxygen partial pressure in the evaporation chamber. Moreover, the intensity of compressive residual stresses decreased linearly as the logarithm of the exposure time of films to room air (aging time) was increased. After a compressive–tensile stress transition observed at a given aging time for films with relatively low densities, the intensity of tensile stresses continued to increase progressively with increasing aging time. The relative variation of residual stresses in SiO2 films was dependent on the mass density of the deposited material. Since the intensity of the absorption band of Si–OH radicals in the infrared spectra of SiO2 films exposed to room air increased with increasing aging time, the evolution of residual stresses was attributed to the effect of the hydration of silica by water vapor contained in room air. A reaction mechanism involving the physical adsorption of water vapor molecules on the SiO2 surface and reaction between adspecies and Si–O–Si species is proposed and discussed to interpret the logarithmic kinetics of residual stress evolution in evaporated SiO2 films exposed to room air.
Electron Microscope Goniometry (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron Microscope GoniometryA. F. Kirkpatrick and E. G. DavisCite this: Anal. Chem. 1948, 20, 10, 965–968Publication Date (Print):October 1, 1948Publication History Published online1 May 2002Published inissue 1 October 1948https://pubs.acs.org/doi/10.1021/ac60022a033https://doi.org/10.1021/ac60022a033research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
European research in rehabilitation (1989)

Professor Miller is at the School of Neurosciences, University of Newcastle upon Tyne; Dr. Cornes is at the Disability Management Research Group, Astley Ainslie Hospital, Edinburgh, United Kingdom.
Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress (2017)

The present study was aimed at investigating the effect of amifostine on myocardial ischemia/reperfusion (I/R) injury of mice and H9c2 cells cultured with TBHP (tert‐butyl hydroperoxide). The results showed that pretreatment with amifostine significantly attenuated cell apoptosis and death, accompanied by decreased reactive oxygen species (ROS) production and lower mitochondrial potential (ΔΨm). In vivo, amifostine pretreatment alleviated I/R injury and decreased myocardial apoptosis and infarct area, which was paralleled by increased superoxide dismutase (SOD) and reduced malondialdehyde (MDA) in myocardial tissues, increased Bcl2 expression, decreased Bax expression, lower cleaved caspase‐3 level, fewer TUNEL positive cells, and fewer DHE‐positive cells in heart. Our results indicate that amifostine pretreatment has a protective effect against myocardial I/R injury via scavenging ROS.
Monodispersity and size control in the synthesis of 20–100 nm quasi-spherical silver nanoparticles by citrate and ascorbic acid reduction in glycerol–water mixtures (2012)

A simple two-step seed-mediated synthesis of monodisperse quasi-spherical silver nanoparticles by citrate and ascorbic acid reduction is presented. Control over monodispersity is achieved by a variety of compounds with hydroxyl groups such as glycerol, ethylene glycol, agarose, or sucrose. The latter can also be used as a matrix for storage.
[Construction and application of retroviral vector carrying green fluorescent protein]. (1998)

The mammalian cell can be efficient gene transfected by retroviral vector carrying GFP. The use of GFP for cell marking represents an important advantage over conventional strategies which typically involve the use of neomycin resistance. GFP, in fact, allows a rapid in vitro selection of transduced cell by FACS. The selection requires only two-day culture with this retroviral vector, compared with 10-14 day culture with a classical retroviral vector.
Aqueous Aldol Catalysis by a Nicotine Metabolite (2002)

Nornicotine, an endogenous tobacco alkaloid and minor nicotine metabolite, can catalyze aldol reactions at physiological pH. Catalysis appears to be due to a covalent enamine mechanism, an unprecedented reaction with small organic molecule catalysts in aqueous buffer. Kinetic parameters for nornicotine as well as other related alkaloids were measured and demonstrate that both the pyrrolidine and pyridine rings are critical for optimal catalysis. Substrate compatibility of this catalyst and its implications in vivo are discussed.
An In Vitro System Recapitulates Chromatin Remodeling at the <i>PHO5</i> Promoter (1999)

The Saccharomyces cerevisiae gene PHO5 is an excellent system with which to study regulated changes in chromatin structure. The PHO5 promoter is packaged into four positioned nucleosomes under repressing conditions; upon induction, the structure of these nucleosomes is altered such that the promoter DNA becomes accessible to nucleases. We report here the development and characterization of an in vitro system in which partially purified PHO5 minichromosomes undergo promoter chromatin remodeling. Several hallmarks of the PHO5 chromatin transition in vivo were reproduced in this system. Chromatin remodeling of PHO5 minichromosomes required the transcription factors Pho4 and Pho2, was localized to the promoter region of PHO5, and was independent of the chromatin-remodeling complex Swi-Snf. In vitro chromatin remodeling also required the addition of fractionated nuclear extract and hydrolyzable ATP. This in vitro system should serve as a useful tool for identifying the components required for this reaction and for elucidating the mechanism by which the PHO5 promoter chromatin structure is changed.
Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells. (1987)

Continuous gastric intubation of mice with the T cell-dependent antigen sheep erythrocytes (SRBC) leads to a state of systemic unresponsiveness to parenteral SRBC challenge, a state termed oral tolerance. The systemic unresponsiveness of mice rendered orally tolerant to SRBC, however, is converted to humoral immune responsiveness by adoptive transfer of effector T contrasuppressor (Tcs) cells. In this study, the authors have isolated and characterized the Tcs cell subset, from the spleens of orally immunized mice, which abrogates oral tolerance. This Tcs cell is a novel cell type, which can be separated from functional T suppressor (Lyt-2+) and T helper (L3T4+) cells, and the effector Tcs cell exhibits a Lyt-1+, 2-, L3T4- phenotype. Furthermore, contrasuppression is not mediated by B cells, including those of the Lyt-1+ phenotype. Adoptive transfer of splenic Lyt-1+, 2-, L3T4- T cells from C3H/HeJ mice given oral SRBC for 21 to 28 days and splenic Lyt-1+, 2-, L3T4- T cells of C3H/HeN mice orally immunized for a shorter interval abrogated oral tolerance. Furthermore, separation of Lyt-1+ T cells into L3T4+ and L3T4- subsets by flow cytometry resulted in Lyt-1+, L3T4+ T cells with helper but not contrasuppressor function, whereas the Lyt-1+, L3T4- T cell fraction abrogated oral tolerance even though it was without helper activity. This Tcs cell subset was also effective when added to cultures of tolerized spleen cells derived from SRBC-fed mice. The effector Tcs cells are antigen-specific, because Tcs cells from SRBC-immunized mice reverse tolerance to SRBC but not to horse erythrocytes (HRBC), and Tcs cells from HRBC-immunized mice reverse tolerance to HRBC but not to SRBC. When splenic T3 (CD3)-positive T cells (Lyt-1+, 2-, and L3T4-) were separated into Vicia villosa-adherent and nonadherent subpopulations, active contrasuppression was associated with the T3-positive and Vicia villosa-adherent T cell fraction. Thus, a distinct Lyt-1+, 2-, L3T4- T cell subset that contains a T3-T cell receptor complex, which can regulate oral tolerance, is present in spleens of orally immunized mice.
Congressional Control of Foreign Assistance (1988)

If not good law, there was worldly wisdom in the maxim attributed to Napoleon that "The tools belong to the man who can use them." We may say that power to legislate for emergencies belongs in the hands of Congress, but only Congress itself can prevent power from slipping through its fingers.
Correlation of physical properties with molecular structure for some dicyclic hydrocarbons having high thermal-energy release per unit volume (1951)

"As part of a program to study the correlation between molecular structure and physical properties of high-density hydrocarbons, the net heats of combustion, melting points, boiling points, densities, and kinematic viscosities of some hydrocarbons in the 2-n-alkylbiphenyl, 1,1-diphenylalkane, diphenylalkane, 1,1-dicyclohexylalkane, and dicyclohexylalkane series are presented" (p. 55).
Prevalencia y grado de parasitación por Myocoptes musculinus en ratones NMRI, C57Bl/6 y Balb/c, en base a cepa, edad y sexo (2015)

espanolA fin de analizar la prevalencia y grado de parasitacion en ratones de laboratorio NMRI, C57B1/6 y Balb/c convencionales producidos en el Bioterio de la Universidad Centroccidental Lisandro Alvarado (UCLA) en Barquisimeto (Venezuela), y su correlacion con la edad y sexo del hospedador, se seleccionaron 50 ratones por cada cepa y sexo, 10 por edad (3, 5, 7, 9 y 14 semanas) (N=300). Se recogieron por duplicado muestras de piel (cuello, dorso-lumbar y ano), mediante tecnica de celofan realizando el recuento del numero de huevos, ninfas y adultos de ectoparasitos por cm2. Solo se identifico la presencia de Myocoptes musculinus localizado preferentemente en dorso independientemente del sexo del animal, con frecuencia superior en ratones C57B1/6 (86%) que en los NMRI (63%) y Balb/c (38%) (P EnglishThe current study was designed to analyze the prevalence and infection intensity by different parasites in conventional NMRI, C57B1/6 and Balb/c laboratory mice produced in the animal research facilities of the Universidad Centroccidental Lisandro Alvarado (UCLA) in Barquisimeto (Venezuela), as well as its correlation with the age and sex of the host. For that purpose, a total of 50 mice for each strain and sex were selected and divided into five age groups of ten each (3, 5, 7, 9 and 14 weeks) (N = 300). Samples of the skin (neck, back-lumbar and anal) were collected by duplicate using the cellophane thick smear technique and the number of eggs, nymphs and adults of ectoparasites per cm2 was estimated. Myocoptes musculinus was the only parasite identified and mostly located in the back at both male and female individual. Infection rates were higher in C57B1/6 (86%) than NMRI (63%) or Balb/c (38%) mice (P
High-Mobility Transport Anisotropy in Few-Layer MoO<sub>3</sub> and Its Origin (2016)

The novel two-dimensional semiconductors with high carrier mobility and excellent stability are essential to the next-generation high-speed and low-power nanoelectronic devices. Because of the natural abundance, intrinsic gap, and chemical stability, metal oxides were also recently suggested as potential candidates for electronic materials. However, their carrier mobilities are typically on the order of tens of square centimeters per volt per second, much lower than that for commonly used silicon. By using first-principles calculations and deformation potential theory, we have predicted few-layer MoO<sub>3</sub> as chemically stable wide-band-gap semiconductors with a considerably high acoustic-phonon-limited carrier mobility above 3000 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, which makes them promising candidates for both electron- and hole-transport applications. Moreover, we also find a large in-plane anisotropy of the carrier mobility with a ratio of about 20-30 in this unusual system. Further analysis indicates that, because of the unique charge density distribution of whole valence electrons and the states near the band edge, both the elastic modulus and deformation potential are strongly directionally dependent. Also, the predicted high-mobility transport anisotropy of few-layer MoO<sub>3</sub> can be attributed to the synergistic effect of the anisotropy of the elastic modulus and deformation potential. Our results not only give an insightful understanding for the high carrier mobility observed in few-layer MoO<sub>3</sub> systems but also reveal the importance of the carrier-transport direction to the device performance.
C-safety: a framework for the anonymization of semantic trajectories (2011)

The increasing abundance of data about the trajectories of personal movement is opening new opportunities for analyzing and mining human mobility. However, new risks emerge since it opens new ways of intruding into personal privacy. Representing the personal movements as sequences of places visited by a person during her/his movements-semantic trajectory-poses great privacy threats. In this paper we propose a privacy model defining the attack model of semantic trajectory linking and a privacy notion, called c-safety based on a generalization of visited places based on a taxonomy. This method provides an upper bound to the probability of inferring that a given person, observed in a sequence of non-sensitive places, has also visited any sensitive location. Coherently with the privacy model, we propose an algorithm for transforming any dataset of semantic trajectories into a c-safe one. We report a study on two real-life GPS trajectory datasets to show how our algorithm preserves interesting quality/utility measures of the original trajectories, when mining semantic trajectories sequential pattern mining results. We also empirically measure how the probability that the attacker's inference succeeds is much lower than the theoretical upper bound established.
The production, properties and selection of ferrosilicon powders for heavy medium separation (1974)

Ferrosilicon of 14 to 16 percent silicon has become widely accepted as the most suitable medium for the heavy-medium separation of ores having a specific gravity in the range of approximately 2. 5 to 4. 0. There are basically two types of ferrosilicon powder available to operators of heavy-medium plants in South Africa: spherical and milled grades. The production processes are described, and the properties of the two types are examined and compared. Guidelines are given for the selection of the correct grade of ferrosilicon for any particular application.
Some Factors Affecting Embryo Storage in Laboratory Animals (1977)

Various factors affect the viability of embryos after freezing and thawing. When mouse embryos are supercooled below -6 degrees C before ice induction (seeding), survival is markedly reduced, apparently by inadequate dehydration of the embryos during subsequent cooling. Immediately after thawing, eight-cell mouse embryos and blastocysts experience a delay before normal embryonic development is resumed. A restorative period in culture combined with a modification of the synchrony between embryo and recipient helps to maximize survival following transfer. No loss of viability was observed in eight-cell mouse embryos after storage at -196 degrees C for four years. The preservation of the embryos of laboratory species other than the mouse and rabbit is limited by our lack of knowledge of the culture requirements for the development of such embryos.
A Case Study of the Supervisory Process: Are We Meeting the Needs of the Marginal and Superior Student? (2005)

No AccessPerspectives on Issues in Higher EducationArticle1 Jun 2005A Case Study of the Supervisory Process: Are We Meeting the Needs of the Marginal and Superior Student? Jennifer Means Jennifer Means West Chester UniversityWest Chester, PA Google Scholar More articles by this author https://doi.org/10.1044/ihe8.1.10 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Anderson, J. L. (1988). The supervisory process. Boston: Little Brown. Google Scholar Bernstein, B., & Lecomte, C. (1979). Supervisory-type feedback effects: Feedback discrepancy level, trainee psychological differentiation and immediate responses.Journal of Counseling Psychology, 26 (4), 295–303. Google Scholar Dowling, S. (2000). Supervision: Strategies for successful outcomes and productivity. Needham Heights, MA: Allyn & Bacon. Google Scholar Larson, L. (1982). Perceived supervisory needs and expectations of experiences vs. inexperienced student clinicians. (Doctoral dissertation, Indiana University, 1981).Dissertation Abstracts International, 42, 475B (University Microfilms No. 82–11, 183). Google Scholar Moses, N., & Shapiro, D. (1996). A developmental conceptualization of clinical problem solving.Journal of Communication Disorders, 29, 199–221. CrossrefGoogle Scholar Powell, T. (1987). A rating scale for measurement of attitudes toward clinical supervision.Supervision, 11, 31–34. Google Scholar Smith, K., & Anderson, J. (1982). Development and validation of an individual supervisory conference rating scale for use in speech-language pathology.Journal of Speech and Hearing Research, 25 (June), 243–251. AbstractGoogle Scholar Stone, D. & Stone, E. (1985). The effects of feedback consistency and feedback favorability on self-perceived tasks competence and perceived feedback accuracy.Organizational Behavior and Human Decision Processes, 36, 167–185. Google Scholar Additional Resources FiguresReferencesRelatedDetailsCited ByPerspectives of the ASHA Special Interest Groups7:2 (445-462)14 Apr 2022Predicting Clinical Skills in Graduate Health Sciences Applicants: A Systematic ReviewNicole Duval Reisfeld and Stacy Lyn Kaplan Volume 8Issue 1June 2005Pages: 10-13 Get Permissions Add to your Mendeley library History Published in issue: Jun 1, 2005 Metrics Downloaded 147 times Topicsasha-topicsasha-article-typesasha-sigsCopyright & Permissions© 2005 American Speech-Language-Hearing AssociationPDF DownloadLoading ...
Physical Prototyping with Smart-Its (2004)

Exploring novel ubiquitous computing systems and applications inevitably requires prototyping physical components. Smart-Its are hardware and software components that augment physical objects with embedded processing and interaction to address this need. Our work, which uses small computing devices called Smart-Its, addresses the need to create embedded interactive systems that disappear from the foreground to become secondary to the physical objects with which people interact during everyday activities. Such systems create new design challenges related to prototyping with embedded technologies and require careful consideration of the physical design context.