gebhart/patrepeval huggingface dataset:
Optimizing parameters of an open-source airway segmentation algorithm using different CT images (2015)

The system represents the first open-source airway segmentation platform. The quantitative evaluation approach presented represents the first repeatable system evaluation tool for like-for-like comparison between different airway segmentation platforms. Results suggest that the algorithm can be considered stable across multiple CT platforms and acquisition parameters and can be considered as a starting point for the development of a complete airway segmentation algorithm.
Spline Fusion: A continuous-time representation for visual-inertial fusion with application to rolling shutter cameras (2013)

This paper describes a general continuous-time framework for visual-inertial simultaneous localization and mapping and calibration. We show how to use a spline parameterization that closely matches the torque-minimal motion of the sensor. Compared to traditional discrete-time solutions, the continuous-time formulation is particularly useful for solving problems with high-frame rate sensors and multiple unsynchronized devices. We demonstrate the applicability of the method for multi-sensor visual-inertial SLAM and calibration by accurately establishing the relative pose and internal parameters of multiple unsynchronized devices. We also show the advantages of the approach through evaluation and uniform treatment of both global and rolling shutter cameras within visual and visual-inertial SLAM systems.
Diffusion in oscillatory pipe flow (1983)

The rate of mass transfer of a diffusing substance along a pipe is augmented by an oscillatory motion of the ambient fluid in the pipe. The increase of the flux is evaluated for the cases of a circular pipe and of a two-dimensional channel. Results are given for a general cross-section in the limiting cases of slow and fast oscillations of the flow.
Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. (1993)

Three of the ets oncogene superfamily members v-ets, Spi-1/PU.1 and Fli-1, have been shown to be directly involved in retroviral-mediated acute erythroleukemias. The Fli-1 gene was found to be rearranged in 75% of the erythroleukemias induced by Friend murine leukemia virus (F-MuLV), suggesting that it could play a key role in cellular transformation. We have previously isolated and characterized the human Fli-1 gene and have found it to be highly homologous (80%) to the human erg-2 gene. Human Fli-1 was also shown to be rearranged in Ewing's sarcoma cases, in which the amino-terminal region of the Fli-1 gene was replaced with a novel coding region of a putative RNA-binding protein, EWS. In this report, we show that the recombinant Fli-1 protein expressed in bacteria binds to DNA in a sequence-specific manner. It appears that Fli-1 and erg proteins fall into the category of ets proteins that recognize limited ets target sequences, unlike c-ets-1, ets-2 and Elk-1. The Fli-1 gene was found to activate the transcription of the reporter gene that was linked to Fli-1 target sequences, suggesting that Fli-1 is a sequence-specific transcriptional activator. Deletion analysis revealed the presence of two autonomous transcriptional activation domains, one at the amino-terminal region (amino-terminal transcriptional activation domain, ATA) and the other at the carboxy-terminal region (carboxy-terminal transcriptional activation domain, CTA). Secondary structural analysis of ATA and CTA domains revealed the presence of helix-loop-helix (H-L-H) and/or turn-loop-turn (T-L-T) regions. From these results it appears that a portion of the Fli-1 ATA domain (H-L-H region) was replaced by the amino-terminal domain of EWS gene in Ewing's sarcoma cases. Therefore alteration in the transcriptional activation function of Fli-1 may be responsible for human malignancies such as sarcomas, leukemias and lymphomas in which this gene is rearranged.
Vinyl carbamates via interaction of alkylidenecarbenes with isocyanates (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyl carbamates via interaction of alkylidenecarbenes with isocyanatesPeter J. Stang and Gary H. AndersonCite this: J. Org. Chem. 1981, 46, 22, 4585–4586Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://pubs.acs.org/doi/10.1021/jo00335a059https://doi.org/10.1021/jo00335a059research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2.5D Glass Panel Embedded (GPE) Packages with Better I/O Density, Performance, Cost and Reliability than Current Silicon Interposers and High-Density Fan-Out Packages (2018)

This paper demonstrates for the first time a next generation high-bandwidth 2.5D glass panel embedding (GPE) architecture with better I/O density, performance, cost and reliability than silicon interposers and high density fan-out packages for heterogeneous integration. Silicon interposers were the first 2.5D technology to enter volume manufacturing, first with TSVs as CoWoS by TSMC and later as embedded bridge EMIB by Intel. High density fan-out packages by chip-first, such as InFO by TSMC, and RDL-first were recently developed. However, all current approaches face challenges in meeting future 2.5D I/O, performance, cost and reliability needs. This paper presents the first demonstration of a revolutionary new concept in scaling power-efficient bandwidth, cost, large package size and board-level reliability, called 2.5D glass panel embedding (GPE). High temperature and low CTE glass reduces die shifts from tens of microns in current molded fan-out to less than 2 microns in GPE. RDL connecting to embedded ICs with 1-2 micron lines and vias overcomes the solder thermo-compression bonding limitations. RDL with much lower resistance and capacitance than BEOL RDL continues power-efficient bandwidth scaling. Ultra-thin glass is readily available in large panels for lower cost. The tailorable CTE of glass allows for reliable direct SMT attach to board of large GPE packages. With a total package thickness of less than 200 microns, this paper describes the fabrication process for an ultra-thin 2.5D GPE, and a systematic parametric process optimization to reduce die shifts to less than 2 microns, leading to the first known demonstration of side-by-side embedding of HBM test chips with all-Cu interconnections at 40 micron I/O pitch.
Try a Hydroponic Garden (1953)

Research Article| January 01 1953 Try a Hydroponic Garden Charles A. Goddard Charles A. Goddard Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1953) 15 (1): 12–14. https://doi.org/10.2307/4438450 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Charles A. Goddard; Try a Hydroponic Garden. The American Biology Teacher 1 January 1953; 15 (1): 12–14. doi: https://doi.org/10.2307/4438450 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Article PDF first page preview Close Modal You do not currently have access to this content.
Cell Cycle-Dependent Expression of Cyclin D1 and a 45 kD Protein in Human A549 Lung Carcinoma Cells (1994)

Cyclin D1, which is suggested to have a role in G1 control during the cell cycle, is genetically linked to BCL-1 and is widely overexpressed in parathyroid, breast, and squamous cancer cells. We postulated that cyclin D1 regulation may also be important in lung cancer. Therefore, we characterized the cell cycle-dependent expression of cyclin D1 at both mRNA and protein levels in synchronized human A549 lung carcinoma cells. Monospecific anti-cyclin D1 C-terminal peptide antibodies recognized both p36cyclinD1 and an as-yet uncharacterized 45 kD protein (p45). A549 cells were synchronized with well-studied drugs. Cyclin D1 mRNA expression remained relatively constant, with less than a twofold fluctuation during the cell cycle and with a minor peak at M phase. However, the p36cyclinD1 protein fluctuated during the A549 cell cycle and was expressed at very low levels in late G1 and at the G1/S boundary, but then increased in S phase and peaked at M phase. In contrast, p45 protein was expressed at relatively high levels in late G1 and reached maximal levels at the G1/S boundary, was expressed at decreased levels in S phase, and then had disappeared by M phase. Moreover, p45 was highly expressed only in transformed alveolar epithelial cells, but not in normal rat alveolar epithelial cells or fetal rat lung fibroblasts in primary cultures. In mink Mv1Lu cells, the expression of p45 was totally blocked by transforming growth factor-beta 1 treatment or contact inhibition. p45 protein was phosphorylated on serine, threonine, and tyrosine residues in A549 cells in culture. The phosphorylation of the p45 protein was cell cycle-regulated and reached its maximal levels at G2/M phase. The p45 protein had a different peptide map from p36cyclinD1 after cleavage with N-chlorosuccinimide. Immunoprecipitation studies showed that p45 was also anti-ubiquitin immunoreactive during the cell cycle. We conclude that p36cyclinD1 and the p45 protein are differentially regulated in a cell cycle-dependent manner in A549 cells. Although p45 is antigenically related to p36cyclinD1, it is probably not a closely cyclin-related protein. We speculate that p45 may be associated with malignant transformation and may play a distinct role from p36cyclinD1 in regulation of the cell cycle in A549 cells.
Role of Mesenchymal Cell Populations in Porcine Serum–Induced Rat Liver Fibrosis (1992)

The role of liver mesenchymal cell populations in porcine serum-induced rat liver fibrosis were studied morphologically and immunohistochemically. Five-week-old rats were intraperitoneally injected with porcine serum twice a week and examined at various intervals between 3 and 24 wk after the initial injection. At an early phase, numbers of fibroblasts and extracellular matrix increased in the walls of central veins and in portal and capsular connective tissues. In the walls of central veins, the number of "second-layer cells" (i.e., the fibroblasts located at the second layer of the wall) increased. Connective tissue septa, accompanying some fibroblasts, extended from these interstitial tissues into the hepatic parenchyma, and their foremost edges came into direct contact with the perisinusoidal stellate cells. The sinusoids adjacent to the newly formed septa collapsed and later disappeared; this process resulted in the formation of hepatic limiting plates along the septa. At a more advanced stage, the interstitial fibroblasts and septal cells-which were derived from interstitial fibroblasts and the stellate cells-increased and became multilayered, constructing three-dimensional cell networks. These networks, together with increased collagen fibrils and elastic fibers, constitute the fibrotic dense connective tissue. In the control rat, smooth muscle cells were positive on vimentin, desmin and smooth muscle-alpha-actin staining. The stellate cells, second-layer cells, capsular and portal fibroblasts were shown to be vimentin and desmin positive and smooth muscle-alpha-actin negative. In the fibrotic liver, septal(fibroblastic) cells were vimentin and desmin positive and smooth muscle-alpha-actin negative. We conclude that not only the perisinusoidal stellate cells but also the interstitial fibroblasts, including the second-layer cells, play substantial role in the development of porcine serum-induced septal fibrosis in rat liver.
Scattering of carbon monoxide molecular ion (CO+) from magnesium surfaces: molecular ion survival and scattered positive and negative ion fractions (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTScattering of carbon monoxide molecular ion (CO+) from magnesium surfaces: molecular ion survival and scattered positive and negative ion fractionsYang Sun Jo, J. Albert Schultz, Thomas R. Schuler, and J. Wayne RabalaisCite this: J. Phys. Chem. 1985, 89, 10, 2113–2118Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 May 1985https://pubs.acs.org/doi/10.1021/j100256a062https://doi.org/10.1021/j100256a062research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Ultrasonic Intensity and Phase Imaging at 3.6 MHz Using Liquid Crystal Conversion (1987)

Absfracf-A new development of the ultrasonic holography technique, using a nematic liquid crystal convertor, is presented, where an image hologram is formed on the convertor with an acoustic lens. It is shown that digital image processing of the fringed pattern, taking a few tens of seconds by an SOSq microcomputer, can provide high-resolution intensity or phase images of various internal material structures, demonstrating applications to nondestructive testing. Highquality intensity images can be made using only an economical analog processing technique if phase images are not required. Imaging delaminations smaller than 1 mm in graphite-epoxy composites is achieved at 3.6 MHz. With this new system a particular form of phase imaging and ultrasonic interferometric holography may become a practical technique.
FLAVOR SENSITIVITY OF SELECTED ANIMAL PROTEIN FOODS TO GAMMA RADIATION (1972)

Raw protein foods derived from 20 different species of animals of different biological classifications were irradiated with gamma irradiation over a range of doses. The intensity of irradiated flavor developed in each case was determined by an expert panel. Relative flavor sensitivities and threshold doses were estimated.
Molecular cloning and expression of rabbit antithrombin III (1992)

A cDNA containing the complete open-reading frame encoding rabbit antithrombin III (AT-III) was isolated from a rabbit liver cDNA expression library, using a specific antibody as a probe. Sequence analysis showed 84% identity between the deduced amino acid sequences of the rabbit and human proteins. A previously described cell-free expression system was used to verify the identity of the clone. The full-length cDNA was inserted into an expression vector, and messenger RNA (mRNA) transcripts generated. In vitro translation of these transcripts, in the presence of [35S]methionine, in an mRNA-dependent rabbit reticulocyte lysate system resulted in the synthesis of a 51-Kd polypeptide, as shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). This nonglycosylated protein was capable of forming SDS-stable complexes with human alpha-thrombin. Complex formation was significantly enhanced following the deletion of nucleotides encoding the signal peptide, and the resultant generation of a 47-Kd nonglycosylated mature protein product. When the template DNA giving rise to this product was internally truncated, two rabbit AT- III deletion mutants were generated that lacked the ability to interact with thrombin, but retained the ability to bind heparin. Cell-free expression plasmids encoding the human and rabbit AT-III mature molecules were manipulated to produce two interspecies fusion proteins. For the first, human codons were used to replace rabbit codons from residue 369–433, while in the second human codons replaced rabbit codons from residue 217–433. Both fusion proteins exhibited less efficient thrombin-complexing ability than the original cell-free- derived mature rabbit AT-III. Thus, portions of AT-III molecules from the two species, despite their high degree of homology, are not interchangeable. Knowledge of the structure of rabbit AT-III, combined with the availability of the rabbit cDNA, will permit defined experimentation aimed at understanding antithrombin III structure relative to its function in vivo.
<title>Low-coherence imaging of cerebral structures in vivo</title> (1997)

We present the results of detailed optical coherence tomographic (OCT) observations of both normal and abnormal rat neocortices obtained in vivo. A compact fast-scanning OCT device employing simultaneously two superluminescent sources of radiation at different wavelengths (0.83 and 1.28 micron) has recorded three dimensional images and performed two-color comparative analysis of the tomograms. We are able to obtain image information at 2.5 mm depths, enabling imaging through the entire rat cerebral cortex. Structures inside and at the surface of the brain have been optically detected, including the dura matter, blood vessels, and the hippocampal/cortical boundary. From these, we have recorded and stored the first OCT album of the cortex. Subsequent histologic analysis shows a good correlation with the OCT tomograms, particularly within the cortical surface layers and the boundary between gray and white matter. We are also able to detect differences between normal and abnormal cerebral structure using OCT.
Experimental demonstration of bipolar optical CDMA system using a balanced transmitter and complementary spectral encoding (1998)

We demonstrate a novel balanced differential optical transmitter for spectrally encoded optical code-division multiple-access (CDMA) systems. The proposed structure is suitable for making optical signaling bipolar using complementary spectral encoding. An optical CDMA link with a pair of programmable transmitter and receiver is tested at the OC-3 transmission speed (155 Mb/s) for single-channel transmission. Unmatched code rejection is also demonstrated.
Immunomodulation of Experimental Autoimmune Encephalomyelitis with Ordered Peptides Based on MHC-TCR Binding Motifs (2001)

T cell-mediated destruction of the myelin sheath causes inflammatory damage of the CNS in multiple sclerosis (MS). The major T and B cell responses in MS patients who are HLA-DR2 (about two-thirds of MS patients) react to a region between residues 84 and 103 of myelin basic protein (1 ). The crystal structure of HLA-DR2 complexed with myelin basic protein(84-102) confirmed that Lys(91) is the major TCR contact site, whereas Phe(90) is a major anchor to MHC and binds the hydrophobic P4 pocket (2 ). We have tested peptides containing repetitive 4-aa sequences designed to bind critical MHC pockets and to interfere with T cell activation. One such sequence, EYYKEYYKEYYK, ameliorates experimental autoimmune encephalomyelitis in Lewis rats, an animal model of MS.
Terahertz time-domain spectroscopy of submonolayer water adsorption in hydrophilic silica aerogel (2004)

We report a terahertz time-domain spectroscopy study of the adsorption of water in hydrophilic silica aerogel. The adsorbed water is in submonolayer form and shows properties of index of refraction similar to those of bulk water but different absorption properties.
Synthesis and manipulation of carbon nanotubes (2003)

This paper reviews recent results in the field of carbon nanotube (CNT) research obtained at our institute at EPFL. We show in particular that CNTs can be synthesized by the catalytic vapour deposition (CVD) technique with high efficiency and purity. Furthermore, we present recent examples of advances in the large-scale production of CNTs as well as in the chemical and mechanical manipulation of CNTs. The chemical manipulation involves covalent and non-covalent sidewall functionalization of single-wall CNTs and preparation of inorganic coatings on CVD-grown nanotubes for the realization of fibres and CNT-reinforced composites. Mechanical manipulation aims at the application of CNTs as tips for scanning probe microscopy.
Low molecular weight chitosan–protamine conjugate for siRNA delivery with enhanced stability and transfection efficiency (2016)

Chitosan is among the few polymers with high biocompatibility and low cytotoxicity.
Measurements of the dielectric relaxation spectra of nine liquids and binary mixtures at 20°C and microwave frequencies (2002)

New measurements of the dielectric permittivity of nine liquids and binary mixtures have been made in the range 1 to 12 GHz. The measurements are combined with data from the literature and Debye type relaxation equations are fitted. Conclusions are formed about the number of relaxation processes for each liquid.
Very wide range tunable CMOS/bipolar current mirrors with voltage clamped input (1999)

In low power current mode signal processing circuits it is often necessary to use current mirrors to replicate and amplify/attenuate current signals and clamp the voltage of nodes with high parasitic capacitances so that the smallest currents do not introduce unacceptable delays. The use of tunable active-input current mirrors would meet both requirements. In conventional active-input current mirrors, stability compensation is required. Furthermore, once stabilized, the input current cannot be made arbitrarily small. In this paper we introduce two new active-input current mirrors that clamp their input node to a given voltage. One of them does not require compensation, while the other may under some circumstances. However, for both, the input current may take any value. The mirrors can operate with their transistors biased in strong inversion, weak inversion, or even as CMOS compatible lateral bipolar devices. If it is biased in weak inversion or as lateral bipolars, the current mirror gain can be tuned over a very wide range. According to the experimental measurements provided in this paper, the input current may spawn beyond nine decades and the current mirror gain can be tuned over 11 decades. As an application example, a sinusoidal g/sub m/-C-based VCO has been fabricated, whose oscillation frequency could be tuned for over seven decades, between 73 mHz and 1 MHz.