gebhart/patrepeval huggingface dataset:
[Relationship between serum cholesterol content, arterial blood pressure and the ABO blood group phenotype in middle-aged men]. (1977)

The diagnosis of arterial hypertension among male volunteers, aged 40 to 49 years, depended to a great extent on the ABO group phenotype. Among those with AB phenotype the chances to have arterial hypertension are 46% higher than among those with the remaining 3 groups of blood. The ABO phenotype appeared to produce no significant effect upon the level of hypercholesterolemia. Males with A and AB phenotypes tended to have hypercholesterolemia more often than others. The obtained data may serve as an additional criterion for early detection of the most vulnerable contingents of individuals so that preventive measures against ischaemic heart disease and arterial hypertension could be taken.
On the development and shape of uriniferous tubules of certain of the higher mammals (1905)

No Abstract. Peer Reviewed http://deepblue.lib.umich.edu/bitstream/2027.42/49593/1/1000040408_ftp.pdf
Photooxidation of methionine and related compounds (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotooxidation of methionine and related compoundsSaul G. Cohen and Salme OjanperaCite this: J. Am. Chem. Soc. 1975, 97, 19, 5633–5634Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://doi.org/10.1021/ja00852a079RIGHTS & PERMISSIONSArticle Views184Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (240 KB) Get e-Alertsclose Get e-Alerts
Über den Mechanismus der dreiphasigen Emulgierung bei der Perlpolymerisation (1956)

Abstract Wasserunlösliche, monomere Kohlenwasserstoffe können in wäßriger Dispersion polymerisiert werden. Die dabei angewandten „Suspensionsstabilisatoren”︁ sind wasserlösliche Kolloide wie Gelatine oder unlösliche, pulverförmige Stoffe wie Bariumsulfat. Im ersten Fall werden Zwei‐Phasen‐, im letzteren Fall Drei‐Phasen‐Emulsionen gebildet. Die Gesetzmäßigkeiten der Drei‐Phasen‐Emulsionen werden mitgeteilt und die Möglichkeiten ihrer Beeinflussung diskutiert. Eine Beeinflussung kann vom Randwinkel her erfolgen, der sich an der Grenzfläche des „Suspensions‐Stabilisators”︁ zwischen zwei flüssigen Phasen ausbildet. Dabei wird in übereinstimmung mit der Theorie eine Phasen‐Umkehr der Drei‐Phasen‐Emulsion erzielt, wenn der „feste Emulgator”︁ nach völliger Bedeckung mit amphipatischen Molekülen von Wasser mit stumpfem Randwinkel benetzt wird. Die Gesamt‐Oberfläche des Perlpolymerisates, die sich nach bekannten Methoden aus der Sieb‐Analyse errechnen läßt, stimmt mit der Fläche des „Suspensions‐Stabilisators”︁ überein, die die Perl‐Oberfläche während des Polymerisations‐Prozesses bedeckt. Das Verhältnis der wäßrigen Phase zu der organischen Phase wird eingehend untersucht. Es ist von größter Bedeutung für die Stabilität der Drei‐Phasen‐Emulsionen. Ausnahmslos können die an der Emulsion gewonnenen Erkenntnisse bei der Herstellung von Perlpolymerisaten bestätigt werden.
When and How to Treat Essential Thrombocythemia (2005)

Essential thrombocythemia is one of the chronic myeloproliferative disorders, a heterogeneous group of diseases involving clonal hematopoietic stem cells that also includes polycythemia vera, idiopathic myelofibrosis, and chronic myelogenous leukemia.1 Among these disorders, essential thrombocythemia has the most favorable outcome: patients with this disease have a life span that nearly rivals that of a healthy population matched by age and sex.2 The principal causes of death in patients with essential thrombocythemia are thrombosis, hemorrhage, and progression to myelofibrosis or acute myelogenous leukemia. The myelosuppressive therapy that prevents vascular events in essential thrombocythemia may itself increase the risk of transformation to . . .
The role of bone morphogenetic proteins in ovarian function. (2003)

Bone morphogenetic proteins (BMPs) represent the largest subclass of growth factors in the transforming growth factor beta (TGF-beta) superfamily. BMPs have proven to be multifunctional regulators of a wide variety of biological processes in numerous types of cell and tissue. The role of inhibins, activins and TGF-betas (which also belong to the TGF-beta superfamily) in reproduction has been studied extensively over the last 15 years. However, there were no reports on the role of BMPs in the mammalian ovary until 1999 when we reported an intrinsic ovarian BMP system replete with BMP ligands, receptors and novel biological functions. Since this report it has become clear that the BMP system plays an important role in the regulation of ovarian function, evidenced by the ability of BMPs to control granulosa cell proliferation and cytodifferentiation, as well as oocyte development. The physiological relevance of the BMP system has recently been highlighted by the discovery that genetic mutations in the BMP-15 ligand or the BMP type IB receptor lead to critical aberrations in folliculogenesis and ovulation. This review provides a current overview of the rapidly emerging field of the BMP system in mammalian ovarian function.
N-version disassembly (2010)

The output of a disassembler is used for many different purposes (e.g., debugging and reverse engineering). Therefore, disassemblers represent the first link of a long chain of stages on which any high-level analysis of machine code depends upon. In this paper we demonstrate that many disassemblers fail to decode certain instructions and thus that the first link of the chain is very weak. We present a methodology, called N-version disassembly, to verify the correctness of disassemblers, based on differential analysis. Given a set of n - 1 disassemblers, we use them to decode fragments of machine code and we compare their output against each other. To further corroborate the output of these disassemblers, we developed a special instruction decoder, the nth, that delegates the decoding to the CPU, the ideal decoder. We tested eight of the most popular disassemblers for Intel x86, and found bugs in each of them.
Incorporation of rat histocompatibility (AgB) antigens into liposomes, and their susceptibility to immune lysis (1978)

Abstract The purification of detergent‐solubilized rat histocompatibility antigens is described. The antigen may readily be incorporated into synthetic vesicles (liposomes) which appear to be unilamellar and between 0.1 μm and 0.2 μm in diameter. The addition of specific antibody leads to the agglutination and precipitation of the liposomes. An enzyme, horseradish peroxidase, may be incorporated into the trapped aqueous phase of the liposome, and its release by antibody and complement can be detected.
The Jitter Tolerance of Fiber Optic Regenerators (1987)

In this paper, we will analyze the effect accumulated jitter has on the decision making process inside the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> th fiber optic regenerator of a long chain of fiber optic regenerators. The criteria for a correct bit decision in the presence of receiver noise, static phase offset, and accumulated input jitter will be derived, and calculations of the bit error rate penalties caused by the presence of known distributions of accumulated input jitter will be made. We will then define the jitter tolerance of a fiber optic regenerator as an effective measure of the regenerator's capability to tolerate incoming accumulated jitter. We will show that excessive bit error rate penalties will not occur if the accumulated input jitter does not exceed the regenerator's measured jitter tolerance template. Finally, the jitter tolerance measurement technique will be used to find the optimum sampling time inside a fiber optic regenerator resulting in a regenerator that is optimized for use in long-haul systems.
Anthelmintic and pesticidal activity of <i>Acorus gramineus</i> (Araceae) is associated with phenylpropanoid asarones (1995)

Abstract The hexane extract of the Chinese medicinal plant Acorus gramineus (Araceae) has previously been shown to possess significant bioactivity towards a range of organisms in in vitro bioassays including digenean, nematode and arthropod targets. In the present study the principal active components in A. gramineus were identified as the phenylpropanoids α‐ and β‐asarone by comparing TLC, HPLC, UV and bioassay data obtained using the hexane extract with those derived with commercially available pure compounds. The known mammalian toxicity and carcinogenicity of asarones means that they are unlikely to have any utility as lead compounds for the development of practical anthelmintics and insecticides.
Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition (2004)

Leptin is a 16-kDa-hormone product of the obese gene synthesized and expressed predominantly by adipose tissues, which has been shown to play major roles in the regulation of body weight, feed intake, energy balance, fertility, and immune system functions. We report an investigation into the association of a previously identified cytosine to thymine missense mutation in exon 2 of the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition in five genetic selection lines of a commercial population of beef cattle. Differences among genotypes in growth, feed intake and feed efficiency were not significant (P > 0.10) though steers homozygous for the thymine allele had positive residual feed intake (i.e., consumed more feed than expected) (+ 0.19 kg d -1 ) whilst steers homozygous for the cytosine allele had negative residual feed intake (-0.18 kg d -1 ). Steers carrying the thymine allele had a higher rate of gain in ultrasound backfat (P = 0.02), ultrasound backfat thickness (P = 0. 06), higher carcass grade fat (backfat) (P = 0.005), lower yield grade (P = 0.01) and lower lean meat yield (P = 0.007). The thymine allele also tended to be associated with higher loin subcutaneous fat (P = 0.07) and was associated with higher brisket subcutaneous fat (P = 0.01), and brisket body cavity fat (P = 0.0001). No associations were found among the different genotypes and real-time ultrasound marbling, ultrasound longissimus thoracis area, carcass marbling and carcass longissimus thoracis area (P > 0.10). Our results show that animals carrying the thymine allele versus the cytosine allele may produce carcasses with poorer grades and lower lean meat yields but do not differ in carcass marbling or other fat depots. Key words: Beef cattle, leptin, feed intake, carcass merit
Unsupervised Feature Ranking and Selection Based on Autoencoders (2019)

Feature selection is one of the most important and widely-used dimension reduction techniques due to its efficiency and intractability of the results. In this paper, we propose a simple but efficient unsupervised feature ranking and selection method by exploiting the geometry of the original feature space using AutoEncoders. Average reconstruction error of training samples by ignoring features, one at time, and the contribution of feature in the latent space (bottleneck of the auto-encoder) are proposed as two useful measures for ranking the features. The proposed method is evaluated for three different tasks: (1) feature selection, (2) discovering image interest points, and (3) extracting important blocks of an images Result on standard benchmarks confirm that the performance of our method is better than state-of-the-art methods.
Comparison of PSP and BSIM4 MOSFET model across various parameters (2010)

In this paper, the standard compact MOSFET models, the BSIM4 and the PSP, are compared up to 40 GHz. Based on the measurement results, the DC, small signal and large signal performance of these models are studied. Although both of these models show good agreements with the measurement, for cases where the gate-source voltage is slightly larger than the threshold voltage, the BSIM4 model shows accurate small signal performance. For the drain source voltage close to zero, the linearity of the PSP model is more reliable.
Measured Impedances of Helical Beam Antennas (1948)

Experimentally determined impedance characteristics are presented for helical antennas. At frequencies too low for the axial or beam mode, the terminal impedance changes greatly with small variations in frequency. However, in the frequency range of the fundamental axial mode, the impedance is relatively constant, especially if the number of turns and the pitch angle of the helix are not too small. This characteristic is an advantage in wide frequency-band applications. For example, the resistance variation of a 5-turn, 18-degree helix over a frequency band of about 1.7 to 1 is only 105 to 145 ohms, and the reactance variation only 0±15 ohms. The effect of the pitch angle and number of turns is discussed.
Detection of Early Anti-p24 HIV Responses in EIA- andImmunoblot-Negative Individuals (1987)

A sensitive and specific radioimmunoprécipitation assay was developed for the detection and analysis of anti-HIV antibody response in human sera with the use of 125I-labelled purified HIV proteins with subsequent sodium-dodecylsulfate gel electrophoresis (125I-RIPA). The 125I-RIPA was shown to be as specific but at least 1 log more sensitive with respect to the detection of gp41^env and p24^gag than the immunoblot analysis as tested in serum samples from several risk groups. Sequential sera were obtained from 9 individuals who seroconverted for HIV antibodies. In 4 individuals, antibody to p24^gag was detected in earlier serum samples by the 125I-RIPA than by EIA or immunoblot; in the other 5 individuals, the detection of p24^gag concorded in enzyme-linked immunosorbent assay (EIA), immunoblot and 125I-RIPA. Moreover, in one of 78 randomly chosen EIA-negative sera from individuals at high risk, antibodies to p24^gag could be detected by the l25I-RIPA. This early seroconversion was confirmed 3 months later by means of immunoblotting and EIA. The specificity of the 125I-RIPA was further demonstrated by analyzing sequential EIA-negative serum samples from 10 individuals at risk for AIDS, collected during 2 years at 3-monthly intervals. All 80 serum samples were found to be negative in the 125I-RIPA and the individuals revealed no signs of HIV infection. The 125I-RIPA technique may be a valuable confirmatory assay in the serology of HIV infections. The sensitivity of this test provides a reliable measure of effective sensitivity when new-generation screening tests are evaluated. In addition, this technique appears to be a specific and sensitive assay to detect antibodies to p24^gag at very early stages of HIV infection.
Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production (2000)

Lactate and ammonia are the two major waste products formed during mammalian cell growth. Accumulation of these side products can have a negative effect on cell growth, and has drawn recent attention because of their inhibitory effects on the specific product synthesis rate. Our aim is to reduce lactate formation in the cell culture by genetically manipulating of the pathway of lactate synthesis with an aim to achieve high monoclonal antibody production. We have partially disrupted the LDH-A gene by homologous recombination in hybridoma cells (ATCC-CRL-1606). The cells that received the newly introduced DNA were selected by G418, and an LDH-deficient cell was identified by a screening method based on medium color changing in 96-well plates. A variant cell, LDH-neo21, was identified through this screening method and was characterized. The specific productivity of lactate by LDH-neo21 cells was 50% lower than that of parental cells. Intracellular LDH enzyme activity was significantly reduced. The cell growth was improved both in terms of cell density and cell viability. Total cell density potentially reached 5 x 10(6) cells/mL while the parental hybridoma cells had a cell density of 3.5 x 10(6) cells/mL, which represented a 30% increase. The antibody production of LDH-neo21 cells was threefold greater than that of parental cells during 5-day batch culture. Polymerase chain reaction (PCR) results showed that at least one copy of the LDH-A gene was disrupted in the LDH-neo21 cells. The variant of the hybridoma cell exhibited a significant advantage of reduced lactate formation in the cell culture with a high concentration of glucose, which led to a higher production of monoclonal antibody. 2001 John Wiley & Sons, Inc.
Three-dimensional point spread functions of an optical heterodyne scanning image processor (2003)

We study the three-dimensional (3-D) imaging properties of an optical heterodyne scanning image processor. The image processor is a two-pupil optical system capable of 3-D imaging coherently or incoherently, depending on the detection scheme used. We derive the imaging properties in terms of the two pupils and then show an important 3-D imaging application in scanning holography by deriving its 3-D point spread functions and compare them with conventional 3-D imaging systems.
Intimate learning: a novel approach for combining labelled and unlabelled data (2005)

This paper introduces a new bootstrapping method closely related to co-training and scoped-learning. The method is tested on a Web information extraction task of learning course names from web pages in which we use very few labelled items as seed data (10 web pages) and combine with an unlabelled set (174 web pages). The overall performance improved the precision/recall from 3.11%/0.31 % for a baseline EM-based method to 44.7%/44.1 % for intimate learning. 1 Intimate learning The expensive nature of labelling data for machine learning methods and the lack of success in using purely unsupervised methods have motivated the study of learning methods
Bistable metamaterial for switching and cascading elastic vibrations (2017)

The realization of acoustic devices analogous to electronic systems, like diodes, transistors, and logic elements, suggests the potential use of elastic vibrations (i.e., phonons) in information processing, for example, in advanced computational systems, smart actuators, and programmable materials. Previous experimental realizations of acoustic diodes and mechanical switches have used nonlinearities to break transmission symmetry. However, existing solutions require operation at different frequencies or involve signal conversion in the electronic or optical domains. Here, we show an experimental realization of a phononic transistor-like device using geometric nonlinearities to switch and amplify elastic vibrations, via magnetic coupling, operating at a single frequency. By cascading this device in a tunable mechanical circuit board, we realize the complete set of mechanical logic elements and interconnect selected ones to execute simple calculations.
Effect of a novel thromboxane A2 synthetase inhibitor on ischemia-induced mitochondrial dysfunction in canine hearts. (1988)

This study was designed to determine the effect of sodium 6-(2-[1-(1H)-imidazolyl]methyl-4,5-dihydrobenzo[b] thiophene)carboxylate (RS-5186), a new thromboxane A2 (TXA2) synthetase inhibitor, on mitochondrial function and lysosomal integrity in ischemic myocardium. 17 anesthetized mongrel dogs were divided into 2 groups. In the control group (n = 11), the left anterior descending arteries (LAD) of the dogs were occluded for 2 h and physiological saline was infused until the end of the experiment. In the RS-5186 treated group (n = 6), 25 min prior to LAD occlusion, RS-5186, 10 mg/kg, was injected for 10 min. 2 h after occlusion, mitochondria were prepared from both ischemic and non-ischemic areas, which were confirmed by Evans' blue dye, and mitochondrial function (respiratory control index: RCI, and the rate of oxygen consumption in state III respiration: St.III O2) was measured polarographically with succinate as substrate. Fractionation of myocardial tissue from both ischemic and non-ischemic areas was also performed, and the activities of lysosomal enzymes (N-acetyl-beta-glucosaminidase: NAG, beta-glucuronidase: beta-gluc) of each fraction were measured. 2-h LAD occlusion induced a significant greater decrease in mitochondrial function from the ischemic area of the control group (RCI: 2.80 +/- 0.45, St.III O2: 133.5 +/- 35.6 natoms/mg protein/min) compared with those from the non-ischemic area (RCI: 4.49 +/- 0.46, St.III O2: 344.0 +/- 31.9).(ABSTRACT TRUNCATED AT 250 WORDS)
Application of Transition State Theory for Thermal Stability Prediction (2003)

Estimations of thermal hazards based on calorimetric experiments can be resource consuming. Therefore, reactive hazard predictions using computational techniques are an attractive option. Typically, prior to detailed experimentation, a screening test is performed on the set of potential reactive chemicals using a differential scanning calorimeter (DSC). The screening tests help to focus the resources on the more reactive systems. The onset temperature (To) and the energy of reaction (−ΔHrxn) are two important parameters obtained from a DSC run. Prediction of thermal stability requires the knowledge of both the thermodynamics and kinetics for the given system. In this paper, the energy of reaction (−ΔHrxn) is approximated by the maximum enthalpy of decomposition (as calculated by the CHETAH program) and transition state theory is employed to estimate the decomposition kinetics of aromatic nitro compounds. The activation energy is approximated as a fraction of the bond dissociation energy (BDE), calculated for the C−NO2 bond, at the B3P86 level of theory with the cc-pVDZ basis set. BDE values are also reported from the semiempirical AM1 theory. These quantum mechanical calculations are combined with an unsteady-state model for a batch reactor to predict onset temperatures for nineteen nitro compounds, which are compared with experimental values.
Transformation of intensities and phases of light beams by a transient "undisplaced" holographic grating (1977)

A description is given of a mechanism of the transient transformation of energies and phases of light beams in recording of dynamic holographic gratings in weakly absorbing media. Simultaneous solution of a nonlinear system of permittivity and Maxwell equations for the transient case gives the parameters of the transformation of light beams used in the recording of such holographic gratings. The calculated parameters of energy exchange are compared with the experimental data for thermal holographic gratings in a solution of cryptocyanine.