gebhart/patrepeval huggingface dataset:
The nuclear periphery of embryonic stem cells is a transcriptionally permissive and repressive compartment (2009)

Chromatin adapts a distinct structure and epigenetic state in embryonic stem cells (ESCs), but how chromatin is three-dimensionally organized within the ESC nucleus is poorly understood. Because nuclear location can influence gene expression, we examined the nuclear distributions of chromatin with key epigenetic marks in ESC nuclei. We focused on chromatin at the nuclear periphery, a compartment that represses some but not all associated genes and accumulates facultative heterochromatin in differentiated cells. Using a quantitative, cytological approach, we measured the nuclear distributions of genes in undifferentiated mouse ESCs according to epigenetic state and transcriptional activity. We found that trimethyl histone H3 lysine 27 (H3K27-Me(3)), which marks repressed gene promoters, is enriched at the ESC nuclear periphery. In addition, this compartment contains 10-15% of chromatin with active epigenetic marks and hundreds of transcription sites. Surprisingly, comparisons with differentiated cell types revealed similar nuclear distributions of active chromatin. By contrast, H3K27-Me(3) was less concentrated at the nuclear peripheries of differentiated cells. These findings demonstrate that the nuclear periphery is an epigenetically dynamic compartment that might be distinctly marked in pluripotent ESCs. In addition, our data indicate that the nuclear peripheries of multiple cell types can contain a significant fraction of both active and repressed genes.
[Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]. (2003)

The results indicate that the strong expression of tumor gene c-jun at the early development and mature stages of intestinal epithelial cells at the special region is related to cellular differentiation, and p38 is probable correlate with cellular mitogenesis.
Effect of Clostridium perfringens epsilon toxin on the blood brain barrier of mice. (1975)

It was shown that Clostridium perfringens epsilon toxin has the effect of allowing the passage of 125I polyvinyl-pyrrolidone and 125I human serum albumin into mouse brain. These substances did not enter the brains of normal control mice. The passage of albumin into the brains of mice poisoned with epsilon toxin was extremely rapid. When large doses of toxin (+/-4 000 MLD) were given death ensued within 2-3 min at which stage 1,5% of the injected albumin had already entered the brain. In cases where smaller doses were given and the time interval between injection and death was longer the figure was increased to 2-2 1/2% of the injected plasma albumin.
Prognostic Significance of Arterial Phase CT for Prediction of Response to Transcatheter Arterial Chemoembolization in Unresectable Hepatocellular Carcinoma (2000)

We found that patients who responded to transcatheter arterial chemoembolization had prolonged survival (p < 0.01). Response correlated closely with tumor vascularity as shown on hepatic arterial phase helical CT.
Revisiting [PtCl<sub>2</sub>(<i>cis</i>-1,4-DACH)]: An Underestimated Antitumor Drug with Potential Application to the Treatment of Oxaliplatin-Refractory Colorectal Cancer (2012)

Although the encouraging antitumor activity of [PtCl(2)(cis-1,4-DACH)] (1; DACH = diaminocyclohexane) was shown in early studies almost 20 years ago, the compound has remained nearly neglected. In contrast, oxaliplatin, containing the isomeric 1(R),2(R)-DACH carrier ligand, enjoys worldwide clinic application as a most important therapeutic agent in the treatment of colorectal cancer. By extending the investigation to human chemotherapy-resistant cancer cells, we have demonstrated the real effectiveness of 1 in circumventing cisplatin and oxaliplatin resistance in LoVo colon cancer cells. The uptake of compound 1 by the latter cells was similar to that of sensitive LoVo cells. This is not the case for all other compounds considered in this investigation. Interaction with double-stranded DNA, investigated by a biosensor assay and by quantum mechanical/molecular mechanical geometry optimization of the 1,2-GG intrastrand cross-link, does not show significant differences between 1 and oxaliplatin. However, the DNA adducts of 1 are removed from repair systems with lower efficiency and are more effective in inhibiting DNA and RNA polymerase.
Developing Real-time System based on Model Driven Architecture (2006)

An object-oriented model driven rapid development process for real-time system is presented in this paper. This process adopts iterative development mode including four phases: analysis, design, implementation and testing base on the model driven architecture and each phase has micro-iterative process. The model is built by Unified Modeling Language. Model driven development method centers on software modeling and primary artifacts designing instead of traditional method, which centers on program codes. This can promote the abstract layer from program code level to model level and implement the testing and verification of system function and performance in model level. It can help to solve the disaccord between models and program codes, the disjointed problem between function and performance of real-time system in traditional methods. The application of model driven development method in computer numerical controller is verified
Control of Standard Engine Test Bench System for Dynamic Road Load Tests (2006)

We developed a new engine test bench system available for dynamic road load tests. The mechanical system of the engine test bench system is as same as a standard engine test bench system. To control it, we adoped I-PD-like 3rd order controller, a virtual vehicle model and engine angular velocity estimator. Our engine test bench system enables to do various tests of an engine without a driveline or a vehicle body, but the engine is loaded as if it were mounted in a vehicle
Small-aircraft atmospheric techniques (1996)

Lidar techniques have been demonstrated for remote detection and quantitative measurement of aerosol and gaseous constituents dispersed in the atmosphere. Lidar systems operated on mobile platforms are particularly useful for three-dimensional observation over large regional areas with high spatial and temporal resolution-airborne lidar is especially well-suited for atmospheric measurements over urban, water, and mountainous areas. However, system installations on small aircraft typically used on environmental research programs requires attention to very restrictive limitations of instrumentation size, weight, and power and to maintaining aircraft airworthiness. Small-aircraft lidar techniques are illustrated by presenting data examples collected in the course of supporting atmospheric research programs onboard the SRI Queen Air. Examples include elastic backscatter lidar analysis of downwind plume transport and diffusion and boundary layer dynamic behavior, ultraviolet differential absorption lidar (DIAL) mapping of vertical ozone distributions downwind of urban and industrial areas; mid-infrared-DIAL measurements of the methane plume downwind of a cattle feed lot; far-infrared DIAL observations of the distribution of SF{sub 6} tracer gas downwind of its near surface release site, and fluorescent lidar tracking of tracer particles to long downwind distances from an elevated tracer release point. 8 refs., 8 figs., 2 tabs.
Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction. (1988)

The effect of nitroprusside in limiting myocardial infarct was compared with that of pinacidil, a new antihypertensive agent with potent coronary vasodilator properties, in instrumented awake dogs subjected to 4 hr of left anterior descending coronary artery occlusion and 20 hr of reperfusion. Dogs were randomly assigned to receive intravenous normal saline, nitroprusside, or pinacidil beginning 40 min after the onset of coronary artery occlusion and continuing throughout the occlusion and the first hour of reperfusion. Nitroprusside and pinacidil were titrated to decrease mean aortic pressure by 25 mm Hg; normal saline had no effect on mean aortic pressure. Other systemic hemodynamic variables were not significantly altered by normal saline or nitroprusside, and myocardial blood flow did not change during normal saline infusion in normal and ischemic myocardium. In contrast, nitroprusside increased the blood flow and the endocardial/epicardial flow ratio in ischemic myocardium. This increase in ischemic ...
Evaluation of the relatedness of Brucella spp. and Ochrobactrum anthropi and description of Ochrobactrum intermedium sp. nov., a new species with a closer relationship to Brucella spp. (1998)

The relatedness of Brucella spp. and Ochrobactrum anthropi was studied by protein profiling, Western blot, immunoelectrophoresis and 16S rRNA analysis. Whole-cell and soluble proteins of brucellae and O. anthropi showed serological cross-reactivities quantitatively and qualitatively more intense than those existing with similar extracts of Agrobacterium spp. Numerical analysis of Western blot profiles of whole-cell extracts showed that O. anthropi LMG 3301 was closer to Brucella spp. than to O. anthropi LMG 3331T, a result not obtained by protein profiling. These differences were not observed by Western blot with soluble fractions, and immunoelectrophoretic analyses suggested that this was due to destruction of conformational epitopes in Western blot procedures with the subsequent simplification of antigenic profile. Analysis of the 16S rRNA sequences of strains previously used in the species definition confirmed that strain LMG 3301, and also LMG 3306, were closer to the brucellae, and that LMG 3331T was in a separate cluster. The LMG 3301 and the LMG 3331T clusters could also be separated by their different colistin sensitivity and by PCR with 16S rRNA Brucella primers, and both methods showed strains of both clusters among clinical isolates classified as O. anthropi by conventional tests. These results and those of previous DNA-DNA hybridization studies [Holmes, B., Popoff, M., Kiredjian, M. & Kersters, K. (1988). Int J Syst Bacteriol 38, 406-416] show that the LMG 3301 cluster and related clinical isolates should be given a new species status for which the name Ochrobactrum intermedium sp. nov. is proposed (type strain is LMG 3301T=NCTC 12171T = CNS 2-75T).
Self‐Cleaning and Next Generation Anti‐Fog Surfaces and Coatings (2008)

Abstract Due to their high surface energy, hydrophilic surfaces are susceptible to contaminations which are difficult to remove and often ruin the surface. Traditional anti‐fog coatings are especially limited by contaminants, as the prevention of fogging is enhanced as hydrophilicity increases. Thus, advanced solutions to fogging are required which incorporate some degree of self‐cleaning ability without significant losses in anti‐fog character. Potential next generation anti‐fog surfaces are characterized with particular emphasis on extended lifetime stimuli‐responsive surfaces. Surfactant‐based surfaces exhibited simultaneous hydrophilicity, necessary for anti‐fogging, and oleophobicity, necessary for contamination resistance. The combination of these features rendered the surface as self‐cleaning. magnified image
3,3‘-Dipyridyl BINOL Ligands. Synthesis and Application in Enantioselective Addition of Et<sub>2</sub>Zn to Aldehydes (2007)

3,3'-di(2-pyridyl) BINOLs (4), prepared in three steps from commercial substances by a combined directed ortho metalation-Negishi cross-coupling protocol, constitute new members of the BINOL ligand family. They are among the most selective, general ligands, providing equal or greater stereoselectivities in the Et2Zn addition to benzaldehydes and cinnamaldehydes (Table 3) than any single BINOL ligand reported to date.
Removal of hydrogen sulfide from simulated geothermal brines by reaction with oxygen. Final report, October 6, 1975-February 4, 1977 (1977)

A process for controlling hydrogen sulfide emissions and corrosivity in geothermal systems has been evaluated on a small laboratory pilot plant scale and shown to be technically feasible. The hydrogen sulfide was oxidized by oxygen injected directly into a 11.4-liter-(3-gallon)-per-minute flowing stream of simulated geothermal brine. The oxidation of the sulfide was complete at oxygen:sulfide mole ratios of 1.25:1 to 1.5:1, depending on temperature and total dissolved solids in the brine. The reaction products were free sulfur, sulfite and sulfate. The ratio of these was dependent upon the oxygen:sulfide mole ratios; but, generally, more than 80% of the sulfide was converted to sulfate, approximately 10% to free sulfur and less than 10% to sulfite.
Use of computerized health claims data to monitor compliance with antibiotic prophylaxis in sickle cell disease (1998)

Computerized claims data can be used, potentially by Medicaid programs and managed care organizations, to identify children with sickle cell disease who probably have low compliance with antibiotic prophylaxis.
Energy Transfer from CdSe/CdS Nanorods to Amorphous Carbon (2011)

Semiconductor nanocrystals placed nearby a metal film significantly change their optical properties. In this work, we examine the change in fluorescence intensity, lifetime, and blinking behavior of individual CdSe/CdS nanorods close to a 9 nm thick amorphous carbon film. Energy transfer between the donor and acceptor was investigated in detail yielding a R(-4) distance dependence for the nanorod-carbon system. The Förster critical distance was determined to be R0=24.9 nm, which is nearly identical with the theoretical value of 24.8 nm predicted by the classical approach. Additionally, antibunching measurements were performed in order to prove the presence of single isolated emitters.
56.1: Sunlight Readability of Digital Micro Shutter Based Display Technology (2010)

Abstract The Pixtronix DMS™ (Digital Micro Shutter) display technology intrinsically provides exceptional image quality due to its optical architecture, device construction and device operation. This technology, based on MEMS micro‐shutters formed on active TFT backplanes, has enabled the development of color sequential, time division gray scale, direct‐view displays achieving breakthrough performance in wide color gamut, high brightness, high contrast ratio and wide view angles, all at roughly 1/4 the power consumption of competing TFT‐LCD or AMOLED displays of the same size and luminance. In addition, DMS™ technology also presents very good sunlight readability in transflective color modes. This readability can be attributed to reflective properties of the DMS™ optical architecture. This reflective nature enhances viewing characteristics of transmissive color modes in high ambient lighting conditions. The reflective performance is obtained without compromising transmissive mode performance as is typically the case in some of the existing display technologies. This paper will explain the performance of DMS™ display in reflective and transflective modes under high ambient lighting conditions.
Thermal coagulation-induced changes of the optical properties of normal and adenomatous human colon tissues<i>in vitro</i>in the spectral range 400–1100 nm (2008)

The absorption coefficients, the reduced scattering coefficients and the optical penetration depths for native and coagulated human normal and adenomatous colon tissues in vitro were determined over the range of 400-1,100 nm using a spectrophotometer with an internal integrating sphere system, and the inverse adding-doubling method was applied to calculate the tissue optical properties from diffuse reflectance and total transmittance measurements. The experimental results showed that in the range of 400-1,100 nm there were larger absorption coefficients (P < 0.01) and smaller reduced scattering coefficients (P < 0.01) for adenomatous colon tissues than for normal colon tissues, and there were smaller optical penetration depths for adenomatous colon tissues than for normal colon tissues, especially in the near-infrared wavelength. Thermal coagulation induced significant increase of the absorption coefficients and reduced scattering coefficients for the normal and adenomatous colon tissues, and significantly reduced decrease of the optical penetration depths for the normal and adenomatous colon tissues. The smaller optical penetration depth for coagulated adenomatous colon tissues is a disadvantage for laser-induced thermotherapy (LITT) and photodynamic therapy (PDT). It is necessary to adjust the application parameters of lasers to achieve optimal therapy.
Effective block recovery schemes for ARQ retransmission strategies (2005)

Many data communication applications such as file transfer require an error free transmission of data which cannot be guaranteed by using only a forward error correction technique. Therefore, automatic repeat request (ARQ) schemes must be applied. This paper presents two new ARQ schemes, named XOR selective repeat and Stutter-XOR. These schemes are both based on the use of the binary XOR operation (bitwise modulo-2 addition) to combine several data blocks into a single block, XOR selective repeat is suitable for point-to-multipoint communication over a broadcast link, whereas Stutter-XOR can be applied to point-to-point as well as point-to-multipoint communications. The aim of both strategies is to minimize the number of retransmitted blocks and hence to increase the throughput. This paper presents simulation results of XOR selective repeat and several variants of the Stutter-XOR in comparison with conventional ARQ schemes.
Comparison of USDA quality grade with tendertec for the assessment of beef palatability. (1997)

Carcasses (n = 265) selected to differ in USDA yield grade were evaluated by expert graders and assessed for tenderness with the Tendertec Mark III Beef Grading Instrument. Tendertec measurements were collected on longissimus lumborum muscles in both sides of each carcass. During fabrication of each left carcass side, a rib section (later converted into three steaks) was removed for aging and subsequent sensory panel evaluation at 14 d and for Warner-Bratzler shear force measurements at 14 and 28 d. Correlation coefficients for repeatability of Tendertec output variables, between left and right carcass sides, were .57, .44, .70, and .65 for Area-2, Area-2B, Power-2, and Power-2B, respectively. Correlations between Tendertec output variables and Warner-Bratzler shear force evaluations performed on steaks aged 14 or 28 d were not different from zero. Sensory panel ratings for amount of connective tissue were correlated (P < .01) with Tendertec output variables Area-2 and Area-2B (r = -.168 and -.154, respectively), and ratings for overall tenderness were correlated (P < .05) with the Area-2 output variable (r = -.131) but the coefficients were very low. Segregation analysis, using Tendertec output variables Area-2 and Power-2, significantly (P < .05) stratified sensory panel ratings for connective tissue amount and overall tenderness. Even though the Tendertec probe detected some differences in connective tissue contributions to rib steak tenderness, it was not better than USDA quality grade at segmenting A-maturity carcasses into anticipated tenderness outcomes, and thus its applicability as a grading instrument may be limited to use on more mature beef carcasses.
A Universal Scheme to Convert Aromatic Molecular Monolayers into Functional Carbon Nanomembranes (2013)

Free-standing nanomembranes with molecular or atomic thickness are currently explored for separation technologies, electronics, and sensing. Their engineering with well-defined structural and functional properties is a challenge for materials research. Here we present a broadly applicable scheme to create mechanically stable carbon nanomembranes (CNMs) with a thickness of ~0.5 to ~3 nm. Monolayers of polyaromatic molecules (oligophenyls, hexaphenylbenzene, and polycyclic aromatic hydrocarbons) were assembled and exposed to electrons that cross-link them into CNMs; subsequent pyrolysis converts the CNMs into graphene sheets. In this transformation the thickness, porosity, and surface functionality of the nanomembranes are determined by the monolayers, and structural and functional features are passed on from the molecules through their monolayers to the CNMs and finally on to the graphene. Our procedure is scalable to large areas and allows the engineering of ultrathin nanomembranes by controlling the composition and structure of precursor molecules and their monolayers.
Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons (2001)

Neurotrophic factors exert many effects on the intact and lesioned adult central nervous system (CNS). Among these effects are prevention of neuronal death (neurotrophism) and promotion of axonal growth (neurotropism) after injury. To date, however, it has not been established whether survival and axonal growth functions of neurotrophins can be independently modulated in injured adult neurons in vivo. To address this question, the ability of brain-derived neurotrophic factor (BDNF) to influence corticospinal motor neuronal survival and axonal growth was examined in two injury paradigms. In the first paradigm, a survival assay, adult Fischer 344 rats underwent subcortical lesions followed by grafts to the lesion cavity of syngenic fibroblasts genetically modified to secrete high amounts BDNF or, in control subjects, the reporter gene green fluorescent protein. In control subjects, only 36.2 +/- 7.0% of the retrogradely labeled corticospinal neurons survived the lesion, whereas 89.8 +/- 5.9% (P < 0.001) of the corticospinal neurons survived in animals that received BDNF-secreting grafts. However, in an axonal growth assay, BDNF-secreting cell grafts that were placed into either subcortical lesion sites or sites of thoracic spinal cord injury failed to elicit corticospinal axonal growth. Despite this lack of a neurotropic effect on lesioned corticospinal axons, BDNF-secreting cell grafts placed in the injured spinal cord significantly augmented the growth of other types of axons, including local motor, sensory, and coerulospinal axons. Immunolabeling for tyrosine kinase B (trkB) demonstrated that BDNF receptors were present on corticospinal neuronal somata and apical dendrites but were not detected on their projecting axons. Thus, single classes of neurons in the adult CNS appear to exhibit disparate survival and growth sensitivity to neurotrophic factors, potentially attributable at least in part to differential trafficking of neurotrophin receptors. The possibility of tropic/trophic divergence must be considered when designing strategies to promote CNS recovery from injury.
The SP2 High-Performance Switch (1995)

The heart of an IBM SP2™ system is the HighPerformance Switch, which is a low-latency, highbandwidth switching network that binds together RISC System/6000® processors. The switch incorporates a unique combination of topology and architectural features to scale aggregate bandwidth, enhance reliability, and simplify cabling. It is a bidirectional multistage interconnect subsystem driven by a common oscillator, and delivers both data and service packets over the same links. Switching elements contain a dynamically allocated shared buffer for storing blocked packet flits. The switch is constructed primarily from switching elements (the Vulcan switch chip) and adapters (the SP2 communication adapter). The SP2 communication adapter uses a variety of techniques to improve bandwidth and offload communication tasks from the node processor. This paper examines the switch architecture and presents an overview of its support software.