gebhart/patrepeval huggingface dataset:
Automated Lipid Identification and Quantification by Multidimensional Mass Spectrometry-Based Shotgun Lipidomics (2009)

This article presents the strategies underlying the automated identification and quantification of individual lipid molecular species through array analysis of multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) data, which are acquired directly from lipid extracts after direct infusion and intrasource separation. The automated analyses of individual lipid molecular species in the program employ a strategy in which MDMS-SL data from building block analyses using precursor ion scans, neutral loss scans, or both are used to identify individual molecular species, followed by quantitation. Through this strategy, the program screens and identifies species in a high-throughput fashion from a built-in database of over 36,000 potential lipid molecular species constructed employing known building blocks. The program then uses a two-step procedure for quantitation of the identified species possessing a linear dynamic range over 3 orders of magnitude and reverifies the results when necessary through redundant quantification of multidimensional mass spectra. This program is designed to be easily adaptable for other shotgun lipidomics approaches that are currently used for mass spectrometric analysis of lipids. Accordingly, the development of this program should greatly accelerate high-throughput analysis of lipids using MDMS-based shotgun lipidomics.
Concept and Application of Three Dimension Virtual Study Technology for Academic e-Learning (2008)

The modality of expression for today’s higher education system has been greatly enriched by the development and application of 3D virtual study technology. First introduce the concepts and effecting factors of constructive theory, and then give out a virtual study target description. Mainly discuss the research and application of a virtual three dimensional study technology, including user interface and interactive technology, database access technology and virtual avatar technology. Finally present a built dynamic interactive Chinese Abacus teaching system, its model and realization methods.
Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir. (2002)

The crystalline ammonium salt of HDP-P-GCV may be a very useful local therapy for herpes family viral retinitis.
HMM-Based speech recognition using multi-dimensional multi-labeling (2005)

This paper describes a new vector quantization (VQ; so-called labeling) method of a speech recognition system based on hidden Markov model (HMM). For improving the VQ accuracy in a simple manner, "multi-labeling" which generates multiple labels at each frame was introduced while keeping a conventional HMM formulation. Furthermore, in order to represent characteristics of speech accurately and effectively, "multi-dimensional labeling" was also introduced which quantizes multiple features such as spectral dynamics and spectrum independently. This labeling method was tested in an isolated word recognition task using 150 Japanese confusable words. The recognition error rate was roughly reduced to 1/2 or less compared with the conventional method.
Probiotics: Growth-Promoting Factors Produced by Microorganisms (1965)

Several species of protozoa, during their logarithmic phases of growth, produce substances that prolong the logarithmic phase in other species. The effect is not as striking as the inhibition of growth caused by antibiotics, but a consistent 50-percent increase in growth has been obtained with Tetrahymena pyriformis in response to a factor produced by Colpidium campylum.
Efecto cicatrizante del gel elaborado del látex de Croton lechleri "Sangre de Drago" (2015)

The aim of this study was to determine the effect of scar gel prepared Croton lechleri latex Sangre de Drago at different concentrations (0.5%, 1% and 2%);...
Increased risk of Parkinson's disease in parents and siblings of patients (1994)

We studied the incidence of Parkinson's disease in 586 first-degree relatives (parents and siblings) of 114 randomly ascertained white patients with idiopathic Parkinson's disease and in 522 first-degree relatives of 114 age-matched unrelated white control subjects. Sixteen percent of patients had a family history as compared to 4% of control subjects (p < 0.01). The age-specific cumulative incidence was higher in the first-degree relatives of patients than in the first-degree relatives of control subjects (p = 0.007). The age-adjusted odds ratio was 3.5 (95% confidence interval: 1.3-9.4; p = 0.014). These results suggest that genes contribute to the etiology of Parkinson's disease.
Real-Time Ball Position Measurement for Football Games Based on Ball's Appearance and Motion Features (2015)

A novel ball tracking system that can be used for actual football games is developed. It measures the positions of a ball from multiple video sequences in real time. The positions can be used for calculating various statistical data and making visual effects for a broadcast program. Although a number of methods for visual object tracking have been proposed, tracking a small ball is still a challenging task. We focused on the motion features of a ball object, adding to its appearance features. We created two discriminate models for tracking a ball in the manner of supervised machine learning. The appearance classifier was trained with visual features of ball images, and the motion classifier was trained with ball trajectories. Tracking results from multiple cameras are integrated in consideration of their reliabilities, and the final ball position is robustly measured. The system was evaluated with two professional football games. The results showed that the proposed system is effective for practical use at football games.
Systematic control of mesh size in hydrogels by initiated chemical vapor deposition (2012)

This investigation has been focused on the development of a cylindrical-shape hydrogel microtube to be used as a biosensor for medical applications. 2-Hydroxyethyl methacrylate copolymerized with ethylene glycol diacrylate p(HEMA-co-EGDA) has been synthesized by initiated chemical vapor deposition (iCVD) using an anodic aluminum oxide (AAO) membrane as a template. Fourier transform infrared spectroscopy (FTIR) was used to determine the reactivity ratio of the copolymerization. Spectroscopy ellipsometry and UV-vis spectrophotometry were performed to study the swelling and mesh size of the polymer layer. Results showed that the polymer mesh size can be tuned by systematic control of cross-linking density to achieve selective diffusion of species through its network.
Observation of a second bulk compressional wave in a porous medium at ultrasonic frequencies (1980)

A second bulk compressional wave has been observed in a water-saturated porous solid composed of sintered glass spheres using an ultrasonic mode conversion technique. The speed of this second compressional wave was measured to be 1040 m/sec in a sample with 18.5% porosity. The theory of Biot, which predicts two bulk compressional waves in porous media, provides a qualitative explanation of the observations. To the author’s knowledge, this type of bulk wave has not been observed at ultrasonic frequencies.
Water Hammer (2004)

Abstract Water hammer refers to fluctuations caused by a sudden increase or decrease in flow velocity. These pressure fluctuations can be severe enough to rupture a water main. Potential water hammer problems should be considered when pipeline design is evaluated, and a thorough surge analysis should be undertaken, in many instances, to avoid costly malfunctions in a distribution system. Every major system design change or operation change—such as the demand for higher flow rates—should include consideration of potential water hammer problems. This phenomenon and its significance to both the design and operation of water systems is not widely understood, as evidenced by the number and frequency of failures caused by water hammer.
Self-collimating photonic crystal polarization beam splitter (2007)

We present theoretical and experimental results of a polarization splitter device that consists of a photonic crystal (PhC) slab, which exhibits a large reflection coefficient for TE and a high transmission coefficient for TM polarization. The slab is embedded in a PhC tile operating in the self-collimation mode. Embedding the polarization-discriminating slab in a PhC with identical lattice symmetry suppresses the in-plane diffraction losses at the PhC-non-PhC interface. The optimization of the PhC-non-PhC interface is thereby decoupled from the optimization of the polarizing function. Transmissions as high as 35% for TM- and 30% for TE-polarized light are reported.
Inhibitory Effects of Green Tea Polyphenols on Growth and Cellular Adherence of an Oral Bacterium,<i>Porphyromonas gingivalis</i> (1996)

Effects of polyphenolic compounds isolated from green tea (Camellia sinensis) on the growth and adherence of Porphyromonas gingivalis onto human buccal epithelial cells were investigated. Green tea polyphenols, especially (-)-epigallocatechin gallate (EGCg) which is a dominant component of tea polyphenols, completely inhibited the growth and adherence of P. gingivalis onto the buccal epithelial cells at concentrations of 250-500 micrograms/ml. Among the polyphenolic compounds, (-)-epicatechin gallate (ECg) and (-)-gallocatechin gallate (GCg) were effective next to EGCg in these activities. On the other hand, (+)-catechin (C(+)), (-)-epicatechin (EC), (+)-gallocatechin (GC), and (-)-epigallocatechin (EGC) had very much less activity. These results indicate that the inhibitory effect on the adherence of P. gingivalis onto the buccal epithelial cells is attributed to the presence of the galloyl moiety, which is ester-linked with the 3-OH of the catechin moiety in the polyphenolic compounds.
Synthesis of Artificially Layered Bi-Sr-Ca-Cu Oxide Films and Their Thermal Stability (1989)

Bi-O/Sr-Ca-Cu-O multilayered films have been synthesized using two target reactive magnetron sputtering. It is shown that the modulation wavelength \varLambda (c/2 for the crystals) can be simply controlled by varying the deposition time for a one layer unit of Sr-Ca-Cu-O while keeping that for Bi-O constant. The films thus obtained have smooth surfaces and have \varLambda's ranging from 12 to 26 Å, i.e., almost equal to those of the crystalline or intergrowth phases o bserved in the Bi-Sr-Ca-Cu-O system. The thermal stability of these artificially layered films is also reported.
One-pot synthesis of dibenzo[b,h][1,6]naphthyridines from 2-acetylaminobenzaldehyde: application to a fluorescent DNA-binding compound (2014)

Dibenzo[b,h][1,6]naphthyridines were synthesized in one pot by reacting 2-acetylaminobenzaldehyde with methyl ketones under basic conditions via four sequential condensation reactions. This method was also applied to the synthesis of 1,2-dihydroquinolines. 6-Methyl-1,6-dibenzonaphthyridinium triflates showed strong fluorescence, and the fluorescence intensities were changed upon intercalation into double-stranded DNA.
Productivity in High Performance Computing (2004)

HPC (high performance computing) has been a popular acronym for decades, and has been applied to many types of architectures, software and applications. The “P” has recently been overloaded to mean both performance and productivity. We present a survey of today’s performance and productivity situation relative to the constituent HPC hardware and software components, and provide some analysis of current controversies and open issues. Since “HPC” will continue to be applied to whatever is happening at the leading edge of computer architecture, system and development software, and algorithms and applications, there is no hope or need to define or clean up terminology (this paper uses HPC to denote hiperc and hiproc, with context determining meaning). Instead, it is important to clarify the whys and wherefores of the state of the art, in order to focus on new work that will maximize future benefits. This paper gives a broad discussion of HPC productivity in terms of effective architectures, run-time system software, and applications development tools. There are costs and trade-offs associated with each of these, and in fact multiple marketplaces consume these products. The range of demands placed on HPC, by owners and users of systems ranging from public research laboratories to private scientific and engineering companies, enrich the topic with many competing technologies and approaches. Rather than expecting to eliminate each other in the short run, these HPC competitors should be learning from one another in order to stay in the race. It seems clear that the dynamics between “commodity” and “custom” building blocks will remain at the center of HPC debates for some time, and indeed these competing forces form the engine of improvement for overall HPC cost/effectiveness.
The Strategic Electronic Day Trader (2000)

The Dream and the Reality. Electronic Trading. Trading Strategies. A Picture is Worth a Thousand Words. High--Probability Shorting. Electronic Trading Tactics. The Biomechanical Trader. Seize the Day. Index.
Changes of Soybean Quality during Storage As Related to Soymilk and Tofu Making (2008)

Soybeans are stored and transported under various humidity and temperature conditions. Soymilk and tofu are two of the most important foods made from whole soybeans. The objective of this study was to investigate the influence of storage conditions on soybean quality as related to soymilk and tofu-making properties. Soybeans of 3 different genotypes (Proto, IA2032, and Vinton 81) were stored in varying conditions: temperature ranging from 4 to 50 degrees C, relative humidity from 55% to 80%, initial moisture content from 6% to 14%, and storage time up to 15 mo depending upon storage conditions. The effects of different storage conditions on soybean color, solids and protein extractability, soymilk pH, tofu yield, tofu solids and protein contents, tofu color, and texture were investigated. While no significant changes occurred for the soybeans stored at 4 degrees C, the soybeans stored at high temperatures (30 to 50 degrees C) exhibited significant quality loss (P < 0.05). The degradation of soybean lightness (Hunter L), color difference (Delta E), and solid extractability exhibited a linear relationship with time. Soak weight decreased at high temperature and relative humidity, but increased at mild storage conditions. Several combinations of storage conditions at temperatures exceeding 30 degrees C produced a drastic loss in tofu yield. Storage also affected the tofu making process by reducing optimum mixing time to produce the highest tofu yield. Varietal difference in soybean storability was observed. The results provided useful information for the soybean processing industry to store soybeans using the optimal storage conditions and to estimate soybean quality after storage.
Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate (1990)

3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was an efficient substrate for the human immunodeficiency virus 1 reverse transcriptase. It was incorporated into both homopolymer and defined sequence DNA-primed RNA templates and DNA-primed DNA templates. The substrate and inhibitor kinetics of both AZTTP and dTTP were dependent on the template-primer and reaction conditions used. dTMP was incorporated into poly(rA).oligo(dT) and into a defined sequence DNA-primed RNA template (when the other three 2'-deoxynucleoside 5'-triphosphates were present) as a conventional substrate, with steady-state Km values of 5-10 microM. The results suggest that the reverse transcriptase was capable of processive DNA polymerization on these DNA-primed RNA templates. In contrast, in the absence of the other three 2'-deoxynucleoside 5'-triphosphates, the time course for incorporation of dTMP into the same defined sequence DNA-primed RNA template was biphasic. A burst of product formation was observed followed by a slow steady-state rate with a Km value of 0.082 microM. AZTMP incorporation into poly(rA).oligo(dT) and into the defined sequence DNA-primed RNA template produced similar biphasic time courses and steady-state Km values. These results were consistent with rate-limiting dissociation of the polymerase.template-primer complex after "forced" termination of polymerization. AZTMP and dTMP were both incorporated into the homopolymer DNA-primed DNA template, poly(dA).oligo(dT), and a defined sequence DNA-primed DNA template as conventional substrates. Their Km values were similar (2-10 microM). The absence of biphasic time courses suggested that dissociation of the DNA-primed DNA templates from the enzyme, after forced termination, was not rate-limiting. This was consistent with a more distributive mode of DNA polymerization. With the defined sequence template-primers and poly(dA).oligo(dT), Ki values for both dTTP and AZTTP were comparable to their Km values. Thus, AZTTP appeared to be a simple competitive substrate-inhibitor with respect to dTTP. AZTTP inhibition of dTMP incorporation into poly(rA).oligo(dT) was linear competitive at low concentrations (0-100 nM) of AZTTP (Ki = 35 nM) but became hyperbolic (decreasing potency) at concentrations of AZTTP above this range. A mechanism for this nonlinear inhibition is discussed.
Automatic Determination of Compatibility in Evolving Services (2011)

A major advantage of Service-Oriented Architectures (SOA) is composition and coordination of loosely coupled services. Because the development lifecycles of services and clients are de-coupled, multiple service versions must be maintained to support older clients. Typically versions are managed within the SOA by updating service descriptions using conventions on version numbers and namespaces. In all cases, the compatibility among services descriptions must be evaluated, which can be hard, error-prone and costly if performed manually, particularly for complex descriptions. In this paper, the authors describe a method to automatically determine when two service descriptions are backward compatible. The authors describe a case study to illustrate version compatibility information in a SOA environment and present initial performance overheads. By automatically exploring compatibility information, a) service developers can assess the impact of proposed changes; b) proper versioning requirements can be put in client implementations guaranteeing that incompatibilities will not occur during run-time; and c) messages exchanged in the SOA can be validated to ensure that only expected messages or compatible ones are exchanged.
Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate (1992)

This study characterizes a congenital hemorrhagic disorder caused by a platelet function defect with the following features: (1) severely impaired platelet aggregation and fibrinogen or von Willebrand factor (vWF) binding induced by adenosine diphosphate (ADP); (2) defective aggregation, release reaction, and fibrinogen or vWF binding induced by other agonists; (3) normal aggregation and release reaction induced by high concentrations of thrombin or collagen; (4) no further inhibition by ADP scavengers of aggregation, release reaction, and fibrinogen or vWF binding, comparable with those observed for normal platelets in the presence of ADP scavengers; (5) normal membrane glycoprotein (GP) composition and normal binding of the anti-GP IIb/IIIa monoclonal antibody 10E5; (6) no acceleration by ADP of binding of the anti-GP IIb/IIIa monoclonal antibody 7E3; (7) normal platelet-fibrin clot retraction if induced by thrombin or reptilase plus epinephrine, absent if induced by reptilase plus ADP; (8) no inhibition by ADP of the prostaglandin E1-induced increase in platelet cyclic adenosine monophosphate, but normal inhibition by epinephrine; (9) defective mobilization of cytoplasmic Ca2+ by ADP; (10) normal binding of 14C-ADP to fresh platelets, but defective binding of [2–3H]-ADP to formalin- fixed platelets. This congenital platelet function defect is characterized by selective impairment of platelet responses to ADP, caused by either decreased number of platelet ADP receptors or abnormalities of the signal-transduction pathway of platelet activation by ADP.
SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads (2018)

Our findings support <i>SLC46A3</i> as a potential patient selection biomarker with immediate relevance to clinical trials involving these ADCs.
Novel 2-Phenylimidazo[1,2-<i>a</i>]pyridine Derivatives as Potent and Selective Ligands for Peripheral Benzodiazepine Receptors:  Synthesis, Binding Affinity, and in Vivo Studies (1999)

The substituent effects at positions 6 and 8 (compounds 17-31) as well as at the amide nitrogen (compounds 32-40) of a series of 2-phenylimidazo[1,2-a]pyridineacetamides were evaluated at both central (CBR) and peripheral (PBR) benzodiazepine receptors. The structure-activity relationship studies detailed herein indicate the key structural features required for high affinity and selectivity for PBR. Substitution on the imidazopyridine nucleus at position 8 with lipophilic substituents and the presence of one chlorine atom at the para position of the phenyl ring at C(2) are crucial features for high binding affinity and selectivity toward PBR. A small subset of active ligands (i.e., 17, 20, 26, 34, and 35) were evaluated in vitro in Xenopus oocytes expressing cloned human GABA(A) receptors for their effects at CBR and in vivo for their ability to stimulate the synthesis of neurosteroids such as pregnenolone, progesterone, allopregnanolone, and allotetrahydrodeoxycorticosterone (THDOC). Compounds 17, 20, 26, and 34 markedly increased the levels of neuroactive steroids in plasma and cerebral cortex, unlike compound 35.
The cholesterol lowering effect of antimalarial drugs is enhanced in patients with lupus taking corticosteroid drugs. (1999)

Antimalarials lower total cholesterol in patients receiving steroids and may minimize steroid induced hypercholesterolemia.
Assessment of tumor microcirculation: A new role of dynamic contrast MR imaging (1997)

With the advances in MR techniques, information related to tumor microcirculation now can be obtained in the clinical setting. This information can be valuable in the assessment of tumor blood supply/oxygenation status and tumor response to therapy. In this article, we review the tracer-kinetic modeling for tumor microcirculatory parameters derived from dynamic contrast MR imaging and report several preliminary results from both an animal model and early experience with human tumors. Despite the application of different MR protocols and tracer-kinetic models, the initial results of these pioneer studies consistently support the role of MR-derived microcirculatory tumor parameters, in providing prognostic information to assess and predict the response of cancers to cytotoxic therapy.