gebhart/patrepeval huggingface dataset:
Dimensional synthesis of a flexible gripper with a high degree of stability (2002)

Since form-closure grasps are a strong condition for stability, they are very useful for applications. Whether form closure can be obtained depends on the design of the end-effector and the geometry of the grasped object. Previously, we proposed a new type of grasping mechanism using closed kinematic chains that can provide form-closure grasps for nearly any geometry of the object. An important design issue is the determination of the link lengths of the closed chain. This paper considers the design with respect to grasp stability. A criterion for evaluating grasp stability is proposed. The link lengths corresponding to an optimal value of the criterion is utilized to obtain a solution for dimensional synthesis. Because the criterion is a nonlinear function of the link lengths, the optimization cannot be obtained by simple computation. To avoid the computational burden in finding the optimal link lengths, we develop a graphical method for determining the link lengths. The grasping of cylindrical objects demonstrates the method.
Rhodium-Catalyzed Regio- and Stereoselective Addition of Diphenylphosphine Oxide to Alkynes (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTRhodium-Catalyzed Regio- and Stereoselective Addition of Diphenylphosphine Oxide to AlkynesLi-Biao Han, Chang-Qiu Zhao, and Masato TanakaView Author Information Research Initiative for Green Chemical Process, National Institute of Advanced Industrial Science and Technology (AIST), AIST Tsukuba Central 5, Tsukuba, Ibaraki 305-8565, Japan %[email protected]Cite this: J. Org. Chem. 2001, 66, 17, 5929–5932Publication Date (Web):July 26, 2001Publication History Received30 March 2001Published online26 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/jo010337zhttps://doi.org/10.1021/jo010337zbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views2041Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Catalysts,Hydrocarbons,Oxides,Rhodium Get e-Alerts
Ueber Aldehyduramide des Acetessigäthers. II (1891)

P. Biginelli: Ueber Aldehgduramide des Acet-essig8thers.11. (Eingegangen am 1. October; mitgetheilt in der Sitzung von Hrn. A. Piuuer.)Eine erste Mittheilung') bezog sich auf das Benzurei'd des Aceteasigathers; in der gegenwartigen zwdten sol1 die Allgrmeingultigkeit der damals besprochenen Reaction dargethan werden.
Cu/Photosensitive-BCB Thin-Film Multilayer Technology for High-Performance Multichip Module (1994)

A new MCM-D technology which enables reliable fabrication of high-performance and low cost MCMs has been developed. The technology is based on Cu/Photosensitive-BCB thin-film multilayer structure. The fabrication process is reduced by using the newly developed Photosensitive-BCB, with a conventional photolythography process. The flexibility on design rules is allowed, because the Cu/BCB structure has the advantages of excellent planarization, and low electrical resistance of signal line. Long-term reliability test was successfully done; thermal cycle(-45/spl deg/C/125/spl deg/), high-temperature aging at 125/spl deg/C, and high-temperature/humidity(85/spl deg/C/85%). A prototype of high-density RISC module fabricated with the developed technology passed all the long-term reliability tests. The excellent electrical performance was also proved through the signal transmission tests with the prototype module.
A Blur Image Blind Identify Algorithm Based on the Edge Feature (2011)

In view of the blur operation in the image tamper, a blur image blind identify algorithm based on the edge feature was proposed. Firstly, the algorithm made the logarithm operation to the image according to the edge feature of out-of-focus blur and artificial blur, and separated image's the incident component and the reflection component. Then it used homomorphism filter to the wavelet region, and obtain the low frequency sub-graph and the high frequency sub-graph under different criterion using wavelet transformation's multi-criteria decompose. Finally, the nature edge of image was corroded by mathematics morphology's corrosion operation, and the blur tamper edge was obtained. The experimental result showed that the algorithm can identify effectively the image that was tampered with blur, and can locate the blur operation trace.
Modification of the Mg/DOBDC MOF with Amines to Enhance CO<sub>2</sub> Adsorption from Ultradilute Gases (2012)

The MOF Mg/DOBDC has one of the highest known CO2 adsorption capacities at the low to moderate CO2 partial pressures relevant for CO2 capture from flue gas but is difficult to regenerate for use in cyclic operation. In this work, Mg/DOBDC is modified by functionalization of its open metal coordination sites with ethylene diamine (ED) to introduce pendent amines into the MOF micropores. DFT calculations and experimental nitrogen physisorption and thermogravimetric analysis suggest that 1 ED molecule is added to each unit cell, on average. This modification both increases the material's CO2 adsorption capacity at ultradilute CO2 partial pressures and increases the regenerability of the material, allowing for cyclic adsorption-desorption cycles with identical adsorption capacities. This is one of the first MOF materials demonstrated to yield significant adsorption capacities from simulated ambient air (400 ppm CO2), and its capacity is competitive with the best-known adsorbents based on amine-oxide composites.
Microbial Stereoselective Hydrolysis of (±)-<i>cis,trans</i>-Ethyl Chrysanthemate for Preparation of (²)-<i>trans</i>-Acid (1991)

Microbial stereoselective hydrolysis of (±)-cis,trans-ethyl chrysanthemate was examined to prepare (+)-trans-chrysanthemic acid. Through the screening of over 228 strains from culture collections, 31 strains were found to have hydrolytic ability. Stereoselective hydrolysis by Arthrobactev (A.) globiformis IFO-12958 gave the optically pure (+)-trans-acid. The composition of cultivation media for production of the hydrolytic activity (the responsible esterase) was optimized. The optimum pH and temperature for hydrolysis of ethyl chrysanthemate were pH 10 and 55°C, respectively. Cells of A. globiformis IFO-12958 were treated with a chemical mutagen and the advantageous mutant SC-6–98–28, the hydrolytic activity of which was enhanced 2.5-fold, was isolated.
Towards Large-Scale Fast Reprogrammable SOA-Based Photonic Integrated Switch Circuits (2017)

Due to the exponentially increasing connectivity and bandwidth demand from the Internet, the most advanced examples of medium-scale fast reconfigurable photonic integrated switch circuits are offered by research carried out for data- and computer-communication applications, where network flexibility at a high speed and high connectivity are provided to suit network demand. Recently we have prototyped optical switching circuits using monolithic integration technology with up to several hundreds of integrated optical components per chip for high connectivity. In this paper, the current status of fast reconfigurable medium-scale indium phosphide (InP) integrated photonic switch matrices based on the use of semiconductor optical amplifier (SOA) gates is reviewed, focusing on broadband and cross-connecting monolithic implementations, granting a connectivity of up to sixteen input ports, sixteen output ports, and sixty-four channels, respectively. The opportunities for increasing connectivity, enabling nanosecond order reconfigurability, and introducing distributed optical power monitoring at the physical layer are highlighted. Complementary architecture based on resonant switching elements on the same material platform are also discussed for power efficient switching. Performance projections related to the physical layer are presented and strategies for improvements are discussed in view of opening a route towards large-scale power efficient fast reprogrammable photonic integrated switching circuits.
Substrate Selectivity of (<sup>t</sup>Bu-Allyl)Co(CO)<sub>3</sub>during Thermal Atomic Layer Deposition of Cobalt (2012)

Tertbutylallylcobalttricarbonyl (tBu-AllylCo(CO)3) is shown to have strong substrate selectivity during atomic layer deposition of metallic cobalt. The interaction of tBu-AllylCo(CO)3 with SiO2 surfaces, where hydroxyl groups would normally provide more active reaction sites for nucleation during typical ALD processes, is thermodynamically disfavored, resulting in no chemical reaction on the surface at a deposition temperature of 140 °C. On the other hand, the precursor reacts strongly with H-terminated Si surfaces (H/Si), depositing ∼1 ML of cobalt after the first pulse by forming Si–Co metallic bonds. This remarkable substrate selectivity of tBu-AllylCo(CO)3 is due to an ALD nucleation reaction process paralleling a catalytic hydrogenation, which requires a coreactant that acts as a hydrogen donor rather than a source of bare protons. The chemical specificity demonstrated in this work suggests a new paradigm for developing selective ALD precursors. Namely, selectivity can be achieved by tailoring the ligands in the coordination sphere to obtain structural analogues to reaction intermediates for catalytic transformations that exhibit the desired chemical discrimination.
Generation of energetic wavelength tunable femtosecond pulses in higher-order-mode fiber (2008)

We demonstrate soliton‐self frequency shift and Cerenkov radiation in higher‐order‐mode solid, silica‐based fibers below 1300 nm. A wavelength shift of 240 nm and pulse energy of 1 nJ were achieved for sub 100‐fs pulses. In addition, a novel wavelength tuning method will be presented.
2,4-Diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-Benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as .alpha.1-adrenoceptor antagonists and antihypertensive agents (1987)

A series of 4-amino-2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1 -yl]-6, 7-dimethoxyquinazoline derivatives was synthesized for evaluation as alpha-antagonists and antihypertensive agents. Most compounds displayed high (nM) binding affinity for alpha 1-adrenoceptors with no significant activity at alpha 2-sites. Selective antagonism of the alpha 1-mediated vasoconstrictor effects of norepinephrine is also characteristic of the series. Structure-activity relationships for alpha 1-adrenoceptor affinity are presented, and structural similarity between the 2,4-diamino-6,7-dimethoxyquinazoline nucleus and norepinephrine is established. An alpha 1-receptor model is presented in which charge-reinforced hydrogen bonding is important for binding of both antagonist and agonist molecules. Antihypertensive activity was evaluated after oral administration (5 mg/kg) to spontaneously hypertensive rats, and several compounds displayed similar efficacy to prazosin when assessed after 6 h. On the basis of alpha 1-adrenoceptor affinity/selectivity in vitro and duration of antihypertensive action in vivo, compound 1 (doxazosin) was selected for further evaluation and is currently progressing through phase III clinical trials.
On Supervised Selection of Bayesian Networks (2013)

Given a set of possible models (e.g., Bayesian network structures) and a data sample, in the unsupervised model selection problem the task is to choose the most accurate model with respect to the domain joint probability distribution. In contrast to this, in supervised model selection it is a priori known that the chosen model will be used in the future for prediction tasks involving more ``focused' predictive distributions. Although focused predictive distributions can be produced from the joint probability distribution by marginalization, in practice the best model in the unsupervised sense does not necessarily perform well in supervised domains. In particular, the standard marginal likelihood score is a criterion for the unsupervised task, and, although frequently used for supervised model selection also, does not perform well in such tasks. In this paper we study the performance of the marginal likelihood score empirically in supervised Bayesian network selection tasks by using a large number of publicly available classification data sets, and compare the results to those obtained by alternative model selection criteria, including empirical crossvalidation methods, an approximation of a supervised marginal likelihood measure, and a supervised version of Dawids prequential(predictive sequential) principle.The results demonstrate that the marginal likelihood score does NOT perform well FOR supervised model selection, WHILE the best results are obtained BY using Dawids prequential r napproach.
Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke (2019)

Ischemic stroke is a predominant cause of disability worldwide, with thrombolytic or mechanical removal of the occlusion being the only therapeutic option. Reperfusion bears the risk of an acute deleterious calcium-dependent breakdown of the blood-brain barrier. Its mechanism, however, is unknown. Here, we identified type 5 NADPH oxidase (NOX5), a calcium-activated, ROS-forming enzyme, as the missing link. Using a humanized knockin (KI) mouse model and in vitro organotypic cultures, we found that reoxygenation or calcium overload increased brain ROS levels in a NOX5-dependent manner. In vivo, postischemic ROS formation, infarct volume, and functional outcomes were worsened in NOX5-KI mice. Of clinical and therapeutic relevance, in a human blood-barrier model, pharmacological NOX inhibition also prevented acute reoxygenation-induced leakage. Our data support further evaluation of poststroke recanalization in the presence of NOX inhibition for limiting stroke-induced damage.
Two-stage unattended object detection method with proposals (2017)

Unattended object detection is a crucial task in visual surveillance systems. However, it is challenging in handling false alarms and miss detection rate. In this paper, a two-stage method for the unattended object detection is proposed where the first stage tries to detect all possible unattended objects and prevent miss detections by considering attributes of objects such as staticness, foregroundness, and abandonment. This stage is called the unattended object proposal stage. In the second stage, our method reduces false alarms with candidates obtaining from the first stage by using a deep learning similarity matching between candidates and the background model. With the capability of reducing false alarms and miss detections, our method can be applied in large-scale deployment systems for unattended object detection.
Attempted Treatment of Scoliosis by Unilateral Vertebral Epiphyseal Arrest (1960)

A series of four cases is reported in which an unsuccessful attempt was made to produce surgically a unilateral growth arrest of the vertebral bodies in an isolated area on the convex side of a lateral curvature of the spine. This surgery was performed on from three to four vertebrae at the level of the maximum thoracic curvature where there was evidence of early lateral wedging. The procedure consisted in excision of a block of bone from the side of convexity, further destruction of the adjacent epiphyseal cartilage by means of a curette, and the insertion of an inlay type of autogenous-bone graft taken from a rib on the convex side of the curve. In three of these patients, the deformity was associated with idiopathic scoliosis. In the fourth, the localized thoracic curvature had occurred in conjuction with an arrested neuroblastoma. Follow-up study of between two and one-half and three years in each patient indicated that the progression of the curve was not altered. Studies of the epiphyseal plates obtained at the time of surgery indicated that there exists a lack of organization and uniformity in the cartilage-cell columns in patients with scoliosis. These changes may be significant in explaining the etiology of idiopathic scoliosis.
ACOUSTIC EMISSION BEHAVIOR OF SAND AS USED IN FOUNDATION BEARING CAPACITY (1976)

The concept of utilizing acoustic emissions to signal the occurrence of deformations and possible failure in geotechnical structures has a long history; for example, miners have long used rock noise as a measure of the safety of a mine, but their interpretations have been largely based on judgment and experiment. In this paper and an extensive series of related papers, an attempt has been made to quantify the intensity of acoustic emissions in soils subjected to various loading conditions and to correlate these measured intensities with the mechanical behavior of the soil. The paper addresses the specific problem of acoustic emissions in sand that is used as a foundation material. It was found that sand with well-distributed particle sizes (rather than particles of predominately one size and angular particles (as opposed to rounded), produce higher levels of acoustic emissions under stress, but the effect of particle size was not significant. This work is a welcome extension and quantification of a well-known concept, and it has the potential for broad application as a procedure for monitoring the stability of building foundations, as well as slopes, dams, tunnels, and a number of other geotechnical works.
Bispyribac-sodium - a new post-emergence herbicide for rice [Oryza sativa L.] (2002)

Bispyribac-sodium e' un nuovo erbicida di post-emergenza, appartenente alla classe chimica dei composti pirimidinil-carbossilici, per il controllo di numerose infestanti delle risaie, con una buona selettivita' nei confronti del riso; in particolare, il prodotto ha evidenziato un'ottima efficacia contro Echinochloa crus-galli con applicazioni a partire dalla 4a foglia fino alla fase di accestimento del riso. L'azione della molecola erbicida si esplica attraverso l'inibizione della sintesi degli aminoacidi a catena ramificata delle infestanti. Bispyribac-sodium presenta inoltre un favorevole profilo ecotossicologico e risulta adatto per l'impiego in risaia, nelle condizioni colturali italiane
Decrease in power output of new light-emitting diode (LED) curing devices with increasing distance to filling surface. (2002)

The blue LED curing devices Elipar FreeLight and GC e-Light showed a significantly higher percentage decrease in power output at a distance of 10 mm from the light guide tip to the radiometer compared to the QTH curing devices. Therefore, although blue LED curing devices might have the same curing potential compared to a QTH device when placed in direct contact to a resin composite, blue LED curing devices may not provide a sufficient cure when placed at a clinically relevant distance of 10 mm to the resin composite surface.
FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone (2011)

The functional interaction between fibroblast growth factor 23 (FGF-23) and Klotho in the control of vitamin D and phosphate homeostasis is manifested by the largely overlapping phenotypes of Fgf23- and Klotho-deficient mouse models. However, to date, targeted inactivation of FGF receptors (FGFRs) has not provided clear evidence for an analogous function of FGFRs in this process. Here, by means of pharmacologic inhibition of FGFRs, we demonstrate their involvement in renal FGF-23/Klotho signaling and elicit their role in the control of phosphate and vitamin D homeostasis. Specifically, FGFR loss of function counteracts renal FGF-23/Klotho signaling, leading to deregulation of Cyp27b1 and Cyp24a1 and the induction of hypervitaminosis D and hyperphosphatemia. In turn, this initiates a feedback response leading to high serum levels of FGF-23. Further, we show that FGFR inhibition blocks Fgf23 transcription in bone and that this is dominant over vitamin D-induced Fgf23 expression, ultimately impinging on systemic FGF-23 protein levels. Additionally, we identify Fgf23 as a specific target gene of FGF signaling in vitro. Thus, in line with Fgf23- and Klotho-deficient mouse models, our study illustrates the essential function of FGFRs in the regulation of vitamin D and phosphate levels. Further, we reveal FGFR signaling as a novel in vivo control mechanism for Fgf23 expression in bone, suggesting a dual function of FGFRs in the FGF-23/Klotho pathway leading to vitamin D and phosphate homeostasis.
The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral hemagglutinin. (1976)

The antigenicity of the hemagglutinins (HA) of five influenza viruses of the A0 and A1 subtypes has been analyzed by means of monoclonal antibodies of murine origin produced in vitro. Secondary monoclonal anti-HA(PR8) antibodies were able to differentiate 14 antigenic determinants (or groups of determinants) on the HA of five influenza virus strains of the A0 and A1 subtypes. Taking into account that certain pairs of determinants delineated on heterologous HA may reflect the heterogeneity of the humoral immune response to a single homologous determinant, the presence of at least eight determinants (host cell-derived determinants not included) on the homologous HA of PR8 and probably on the HA of influenza viruses in general is postulated. Three types of HA-determinants of A0 and A1 influenza virus strains could be distinguished: strain-specific, partially shared, and determinant(s) common to all five virus strains tested. Roughly 40, 55, and 5%, respectively, of the secondary anti-PR8 antibodies of BALB/c mice were directed against determinants belonging to either of the three types.
Optimization of LMP‐specific CTL expansion for potential adoptive immunotherapy in NPC patients (2009)

Nasopharyngeal carcinoma (NPC) is Epstein-Barr virus (EBV) positive in all undifferentiated cases, expressing the latency II phenotype of latent membrane proteins (LMPs) 1 and 2, in addition to EBV nuclear antigen (EBNA) 1. Several studies have attempted to treat NPC with EBV-specific cytotoxic T lymphocyte (CTL) with a partial response. To improve this therapy, there is a need to expand CTL targeted to the latency II antigens of EBV, rather than the immunodominant EBV nuclear antigens 3-6 peptides typically expanded by lymphoblastoid cells. In order to maximize the expansion of LMP-specific CTL in vitro for use in adoptive immunotherapy of nasopharyngeal carcinoma patients, we used lymphoblastoid cell lines coated with synthetic peptides corresponding to CTL determinants from the LMP proteins. We investigated several issues pertaining to the expansion of an immunologically weak CTL response, including peptide and interleukin-2 concentration, and screening assays for selecting the optimal peptide for use in expansion of LMP-specific CTL. Although screening of ex vivo peripheral blood mononuclear cells did not prove to be useful in the selection of an LMP peptide for use in CTL cultures, the peptide and interleukin-2 concentrations were critical for the maximum expansion of CTL. Therefore, it is imperative that stimulation protocols are optimized for the expansion of LMP-specific CTL.