gebhart/patrepeval huggingface dataset:
Novel Tracers and Their Development for the Imaging of Metastatic Prostate Cancer (2008)

There are presently no accurate methods of imaging prostate cancer metastases to bone. An unprecedented number of novel imaging agents, based on the biology of the disease, are now available for testing. We reviewed contemporary molecular imaging modalities that have been tested in humans with metastatic prostate cancer, with consideration of the studies' adherence to current prostate cancer clinical trial designs. Articles from the years 2002 to 2008 on PET using (18)F-FDG, (11)C-choline, (18)F-choline, (18)F-flouride, (11)C-acetate, (11)C-methionine, and (18)F-fluoro-5alpha-dihydrotestosterone in patients with metastatic prostate cancer were reviewed. Although these studies are encouraging, most focus on the rising population with prostate-specific antigen, and many involve small numbers of patients and do not adhere to consensus criteria for clinical trial designs in prostate cancer. Hence, although many promising agents are available for testing, such studies would benefit from closer collaboration between those in the fields of medical oncology and nuclear medicine.
The 5th Generation Mobile Wireless Networks- Key Concepts, Network Architecture and Challenges (2015)

The process of learning, our way of working, thinking and interaction has all changed due to the internet supported by world wide mobile revolution. Currently the 4G’s concept is marching towards the standardization phase. So time has come to introduce a new technology in which we can connect to multiple wireless technologies, networks, terminals and applications, all simultaneously and can also switch between them. This latest technology is named as 5G. 5G (5th generation mobile networks or 5th generation wireless systems) is a term used in some research papers and projects to denote the next major phase of mobile telecommunications standards beyond the current 4G/IMT- Advanced standards. 5G is considered as beyond 2020 mobile communications technologies. This upcoming technology will support IPv6 and flat IP. This paper addresses an overall description of the 5G systems and its architecture, standard, benefits, challenges in deployment, Security issues and scope of 5G technologies. This paper will also focus the researches being made on worldwide wireless web (WWWW), Dynamic Adhoc Wireless Network (DAWN) and real wireless world.
Books (1983)

Journal Article Books Get access The Book on the Art of Dancing Edited by ANTONIO CORNAZANO Translated by Madeleine Inglehearn Dance Books, London, 1981 £4.95 HOWARD MAYER BROWN HOWARD MAYER BROWN Search for other works by this author on: Oxford Academic Google Scholar Early Music, Volume 11, Issue 3, July 1983, Pages 369–371, https://doi.org/10.1093/earlyj/11.3.369 Published: 01 July 1983
Virtual coordinates for ad hoc and sensor networks (2004)

In many applications of wireless ad hoc and sensor networks, position-awareness is of great importance. Often, as in the case of geometric routing, it is sufficient to have virtual coordinates, rather than real coordinates. In this paper, we address the problem of obtaining virtual coordinates based on connectivity information. In particular, we propose the first approximation algorithm for this problem and discuss implementational aspects.
Temporal and Spatial Changes in Cartilage-Matrix-Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression (2011)

Various forms of mechanical stimulation have been shown to enhance chondrogenesis of mesenchymal stem cells (MSCs). However, the response of MSCs undergoing chondrogenesis to such signals has been shown to depend on the temporal application of loading. The objective of this study was to determine the effect of dynamic compression on cartilage-matrix-specific gene expression and to relate this response to the local biochemical environment and cell phenotype at the time of loading. At 0, 7, 14, and 21 days extracellular matrix (ECM) deposition within MSC-seeded agarose hydrogels due to transforming growth factor-β3 stimulation was determined biochemically and histologically, and then reverse transcription-polymerase chain reaction was used to examine the effects of dynamic compression on cartilage-matrix-specific gene expression. The results of these experiments show that the local environment in the core of the constructs is more favorable for chondrogenesis in comparison to the annulus, as evident from both ECM synthesis and gene expression. Additionally, we found that the response of the cells to mechanical stimulus varied with both the spatial region within the constructs and the temporal application of loading. Dynamic compression applied at day 21 was found to enhance levels of cartilage matrix gene expression following a peak in expression levels at day 14 in free swelling constructs, suggesting that mechanical signals play a key role in the maintenance of a chondrogenic phenotype. The application of mechanical stimulus to enhance cartilage ECM synthesis may be an important tool in regenerative medicine-based cartilage repair. The results of this study suggest that a chondrogenic phenotype and/or a well-developed pericellular matrix must first be established before dynamic compression can have a positive effect on cartilage-matrix-specific gene expression.
Application of optimal transport and the quadratic Wasserstein metric to full-waveform inversion (2017)

Conventional full-waveform inversion (FWI) using the least-squares norm as a misfit function is known to suffer from cycle-skipping issues that increase the risk of computing a local rather than the global minimum of the misfit. The quadratic Wasserstein metric has proven to have many ideal properties with regard to convexity and insensitivity to noise. When the observed and predicted seismic data are considered to be two density functions, the quadratic Wasserstein metric corresponds to the optimal cost of rearranging one density into the other, in which the transportation cost is quadratic in distance. Unlike the least-squares norm, the quadratic Wasserstein metric measures not only amplitude differences but also global phase shifts, which helps to avoid cycle-skipping issues. We have developed a new way of using the quadratic Wasserstein metric trace by trace in FWI and compare it with the global quadratic Wasserstein metric via the solution of the Monge-Ampère equation. We incorporate the quadratic Wasserstein metric technique into the framework of the adjoint-state method and apply it to several 2D examples. With the corresponding adjoint source, the velocity model can be updated using a quasi-Newton method. Numerical results indicate the effectiveness of the quadratic Wasserstein metric in alleviating cycle-skipping issues and sensitivity to noise. The mathematical theory and numerical examples demonstrate that the quadratic Wasserstein metric is a good candidate for a misfit function in seismic inversion.
Effect of atmosphere on spectral emission from plasmas generated by the laser microprobe (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of atmosphere on spectral emission from plasmas generated by the laser microprobeWilliam J. Treytl, Kenneth W. Marich, James B. Orenberg, Peter W. Carr, D. Craig. Miller, and David. GlickCite this: Anal. Chem. 1971, 43, 11, 1452–1456Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/ac60305a020https://doi.org/10.1021/ac60305a020research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene <i>Ube3a</i> (2010)

A defect in the maternal copy of a ubiqutin ligase gene Ube3a can produce a neurodevelopmental defect in human children known as Angelman syndrome. We investigated the role of the maternally expressed Ube3a gene in experience-dependent development and plasticity of the mouse visual system. As demonstrated by optical imaging, rapid ocular dominance (OD) plasticity after brief monocular deprivation (MD) was severely impaired during the critical period (CP) in the visual cortex (VC) of Ube3a maternal-deficient (m-/p+) mice. Prolonged MD elicited significant plasticity in m-/p+ mice that never matched the level seen in control animals. In older animals after the CP, 7-day MD elicited mild OD shifts in both control and m-/p+ mice; however, the OD shifts in m-/p+ mice lacked the strengthening of visual responses to the two eyes characteristic of normal adult plasticity. Anatomic effects of the maternal deficiency include reduced spine density on basal, but not apical, dendrites of pyramidal neurons in the binocular region of the VC. Imprinting of Ube3a expression was not fully established in the early postnatal period, consistent with the normal development of cortical retinotopy and visual acuity that we observed in m-/p+ mice, but was fully established by the onset of the CP. These results demonstrate that paternal and maternal genomes are not functionally equivalent for cortical plasticity, and that maternally expressed Ube3a is required for normal experience-dependent modification of cortical circuits during and after the CP.
Long-term survival and outcome of patients originally given<i>Mycobacterium vaccae</i>for metastatic malignant melanoma (2013)

Given this remarkable outcome in stage IV metastatic melanoma and its lack of toxicity we propose that this would make a promising candidate for randomized trials for stage III fully resected melanoma.
The Structure and Function of <i>Francisella</i> Lipopolysaccharide (2007)

A key factor in the biology of Francisella spp. is lipopolysaccharide (LPS). Francisella LPS has many unique structural properties and poorly activates proinflammatory responses due to its lack of interaction with toll-like receptor 4 (TLR4). The LPS of this organism can be modified by various carbohydrates including glucose, mannose and galactosamine, which affect various aspects of virulence. Spontaneously occurring colony variants of F. tularensis have altered LPS. This altered LPS may account for the novel phenotypes of these variants that include effects on susceptibility to killing by normal human serum, intracellular survival and animal virulence. Mutants devoid of O-antigen (directed mutants in O-antigen biosynthetic genes) show reduced intracellular survival and mouse virulence. Thus, this surface component is important in F. tularensis pathogenesis, and the inability of the LPS to alarm the immune system coupled with its frequent modification/alteration likely aid the success of this pathogen during human infection.
IL-6 Signaling Promotes Tumor Growth in Colorectal Cancer (2004)

Recent investigations support an important role for TGF-beta in the development of colorectal cancer. However, the molecular consequences of TGF-beta signaling in the colon remains incompletely understood. In a recent study in Immunity, we analyzed the role of TGF-beta in a murine model of colon cancer. Using transgenic mice overexpressing TGF-beta or a dominant negative TGF-beta receptor II under control of the CD2 minigene, we show that TGF-beta signaling in tumor infiltrating T lymphocytes regulates the growth of dysplastic colon epithelial cells, as determined by histology and a novel system for high resolution chromoendoscopy in vivo. At the molecular level, TGF-beta signaling in T cells regulated STAT-3 activation in tumor cells via IL-6. IL-6 signaling required tumor cell derived soluble IL-6R rather than membrane bound IL-6R and suppression of such TGF-beta-dependent IL-6 trans-signaling prevented tumor progression in vivo. Similar to these observations in mice, here we show that human colon cancer tissue expressed only low amounts of membrane bound IL-6R. In contrast, expression and activity of the matrix metalloproteinase TACE were increased. In summary, our data provide novel insights into the role of TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on an inhibition of TGF-beta-dependent IL-6 trans-signaling.
Coplanar Silicon-Coupled Josephson Junctions with Recessed Electrode Structure (1987)

On fabrique des jonctions Josephson coplanaires de type couple par pont de silicium avec une structure d'electrodes de niobium en retrait par une nouvelle technique de planarisation et on observe le courant Josephson pour la distance 50 nm des electrodes. Cette structure a une possibilite d'application comme dispositif a 3 bornes (FET) controle par une grille isolee
Human Leukocyte Elastase Inhibitors: Analog Based Studies to Design Novel Lead Compounds for the Treatment of COPD (2010)

Human Leukocyte Elastase is a serine protease that is released from leukocytes upon inflammatory stimulus. HLE is thought to aid in the migration of neutrophils to extra vascular compartments through degradation of a number of structural proteins including elastin. Normally this enzyme is kept in check by indigenous inhibitors, most notably alpha-1 proteinase. However alpha-1 p1 may be damaged by cigarette smoking, or because of genetic defect, produced in insufficient quantities. in either case , the balance between HLE and alpha -1 p1 is upset which can lead to tissue damage which manifests itself in diseases such as chronic obstructive pulmonary diseases, asthma, emphysema ,cystic fibrosis, and adult respiratory distress syndrome. Consequently there has been concerted effort to develop low molecular weight inhibitors of HLE to treat these disease states.We have performed Pharmacophore and 3D-QSAR studies for developing novel HLE inhibitors using the Catalyst 4.7 and Cerius2 program suite respectively. QSAR equations has been generated for 58 HLE inhibitors employing Molecular Field Analysis (MFA) as well as Receptor surface Analysis (RSA) using Genetic function approximation (GFA) as regression method. The best equations with training set consisting 40 molecules, produced r2 value of 0.845 and r2cv value of 0.839 in MFA-model and r2 value of 0.880 & r2cv of 0.856 in the RSA-model. For the 18 test set molecules predicted activities have correlation of 0.845 and 0.880 for MFA and RSA with observed activities.Pharmacophore models were generated using 21 molecules as training set. The best quantitative pharmacophore model consists of hydrogen bond acceptor, hydrophobic aliphatic and hydrophobic aromatic feature. For the training set the accuracy in predicting active and inactive compounds was 80%. The best pharmacophore hypothesis yielded a RMS deviation of 1.06 and a Correlation coefficient of 0.943 with a Cost difference (Null cost minus Total cost) of 79.02. The obtained pharmacophore models were validated on 50 test molecules to give correlation value of 0.846.
Microbial disinfection capacity of municipal solid waste (MSW) composting (1998)

The disinfection capacity of a municipal solid waste (MSW) composting plant (Siloda) has been evaluated. In spring and summer, MSW was followed during the composting process from raw material to mature compost and long-term storage (1 year). Ascaris eggs, Salmonella, Shigella, total streptococci, faecal streptococci, total coliforms, faecal coliforms and Escherichia coli were studied. Disinfection was successful in terms of a decrease in faecal contamination indicators and disappearance of faecal pathogens. Faecal coliform concentration in raw waste reached 2.1 x 10(8) cfu g-1 dry weight in spring (CI 95%:5.2 x 10(7)-3.4 x 10(8)) and 7.2 x 10(8) cfu g-1 dry weight (1 x 10(8)-1.7 x 10(9)) in summer, and fell to less than 100 cfu g-1 dry weight within 20 d. Faecal streptococci concentrations reached 8.7 x 10(8) cfu g-1 dry weight (3.7 x 10(8)-1.3 x 10(9)) in spring and 2.0 x 10(9)cfu g-1 dry weight (5.6 x 10(8)-3.4 x 10(9)) in summer, and fell to 8.7 x 10(4) cfu g-1 dry weight (6.9 x 10(4)-1.0 x 10(5)). No seasonal pattern of contamination, mainly of animal origin, was observed. Microbiological quality of finished compost depends on the storage conditions. Therefore, the storage stage should be viewed as part of the composting process. Monitoring disinfection capacity of MSW composting needs to combine several microbial populations.
Capacity evaluation of the EDGE concept for enhanced data rates in GSM and TDMA/136 (2003)

This paper evaluates the capacity of the EDGE concept. To vouch for a high simulation accuracy, a novel interface between link and system simulations is used, where multipath fading is included on a system level. This allows detailed performance analyses with and without frequency hopping, as well as for different channel types. The presented results show that spectral efficiencies exceeding 0.45 bps/Hz/site and user data rates exceeding 384 kbps are achievable with EDGE. Compared to standard General Packet Radio Service (GPRS), these figures are more than doubled.
[Posterior semicircular canal occlusion with microwave assisted technique in guinea pigs]. (2001)

Posterior semicircular occlusion with microwave technique is suggested as an effective and safe treatment for the benign paroxysmal positional vertigo.
Il progetto Strada: un caso di formazione a distanza in ambito universitario (2002)

Analisi di un progetto di formazione misto distanza/presenza e degli studi di validita' su di esso applicati.
Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels (2012)

Change of chirality is a useful tool to manipulate the aqueous self-assembly behaviour of uncapped, hydrophobic tripeptides. In contrast with other short peptides, these tripeptides form hydrogels at a physiological pH without the aid of organic solvents or end-capping groups (e.g. Fmoc). The novel hydrogel forming peptide (D)Leu-Phe-Phe ((D)LFF) and its epimer Leu-Phe-Phe (LFF) exemplify dramatic supramolecular effects induced by subtle changes to stereochemistry. Only the d-amino acid-containing peptide instantly forms a hydrogel in aqueous solution following a pH switch, generating long fibres (>100 μm) that entangle into a 3D network. However, unexpected nanostructures are observed for both peptides and they are particularly heterogeneous for LFF. Structural analyses using CD, FT-IR and fluorescent amyloid staining reveal anti-parallel beta-sheets for both peptides. XRD analysis also identifies key distances consistent with beta-sheet formation in both peptides, but suggests additional high molecular order and extended molecular length for (D)LFF only. Molecular modelling of the two peptides highlights the key interactions responsible for self-assembly; in particular, rapid self-assembly of (D)LFF is promoted by a phenylalanine zipper, which is not possible because of steric factors for LFF. In conclusion, this study elucidates for the first time the molecular basis for how chirality can dramatically influence supramolecular organisation in very short peptide sequences.
Density Functional Studies on the Pauson−Khand Reaction (2001)

The Pauson--Khand reaction represents a one-step Co(2)(CO)(8)-catalyzed synthesis of cyclopentenone through [2 + 2 + 1] assembly of one molecule each of alkene, alkyne, and carbon monoxide. Density functional studies (B3LYP/631LAN) on the reaction pathway of the Pauson--Khand (PK) reaction reported here for the first time provides valuable information on the structures and energetics of various intermediates and transition states. The PK reaction consists of olefin insertion, CO insertion, and reductive elimination steps. The olefin insertion step was found to be an irreversible step that determines the stereo- and regiochemistry of the overall reaction. The following steps are low activation energy processes and reversible. The bond-forming events occur only on one of the two metal atoms, while the second metal atom not only acts as an anchor that fixes the metal cluster to the organic substrate but also exerts electronic influences on the reaction at the first atom.
Multiobjective design optimization of air-core linear permanent-magnet synchronous motors for improved thrust and low magnet consumption (2006)

Although air-core linear permanent-magnet (PM) synchronous motors are widely used in precision applications because of their advantages such as fast dynamics, lack of detent force, and negligible iron loss, they basically suffer from low developed thrust, thrust ripple, and excessive use of permanent-magnet materials, all of which lead to undesirable performance and high production cost. In this paper, we analyze performance characteristics of an air-core linear PM synchronous motor by varying motor design parameters in a layer model and a d-q model of the machine. We propose a multiobjective design optimization to improve thrust, thrust ripple, and consumed magnet volume independently and simultaneously by defining a flexible objective function. A genetic algorithm is employed to search for optimal designs. The results confirm that desirable thrust mean and substantial reduction in magnet volume and thrust ripple can be achieved. We draw several design conclusions from the motor analysis and design optimization. Finally, we carry out a time-stepping finite-element analysis to evaluate the effectiveness of the machine models and the optimization method.
A Naturally Occurring Mutation in FcγRIIA: A Q to K127 Change Confers Unique IgG Binding Properties to the R131 Allelic Form of the Receptor (1998)

FcγRIIa is widely expressed on hematopoietic cells. There are two known allelic polymorphic forms of FcγRIIa, FcγRIIa-R131 and FcγRIIa-H131, which differ in the amino acid at position 131 in the second Ig-like domain. In contrast to FcγRIIa-R131, FcγRIIa-H131binds hIgG2 but not mIgG1, and this differential binding has clinical implications for host defense, autoimmune disease, immunohematologic disease, and response to therapeutic monoclonal antibodies. We identified a novel FcγRIIA genotype in a healthy individual homozygous for FcγRIIA R/R131 in whom a C to A substitution at codon 127 changes glutamine (Q) to lysine (K) in one of the two FcγRIIA genes. This individual's homozygosity for FcγRIIA-R/R131 leads to the prediction that the receptors on her cells would not bind hIgG2. Monocyte and neutrophil phagocytosis of hIgG2-opsonized erythrocytes was significantly higher (P < .05) for cells from this K/Q127, R/R131 individual than for Q/Q127, R/R131 donors. Platelet aggregation stimulated by an mIgG1 anti-CD9 antibody in this individual was significantly different (P < .05) from Q/Q127, H/R131 and Q/Q127, H/H131 donors and similar to Q/Q127, R/R131. Our data show that the K127/R131 receptors have a unique phenotype, binding both hIgG2 and mIgG1. Further functionally significant mutations in human Fcγ receptors and possible novel mechanisms for inherited differences in disease susceptibility should be sought with unbiased screening methods.