gebhart/patrepeval huggingface dataset:
High-frequency modulation characteristics of redVCSELs (1997)

The authors have measured small- and large-signal modulation response characteristics of a red VCSEL (λ = 670 nm). A small-signal 3 dB bandwidth of 11 GHz was recorded at a bias current of 16 mA. The small-signal response for each bias current was fit to an analytic model to determine the resonance and damping factor. From these data the differential gain coefficient and K-factor were estimated. Large signal digital measurements were conducted showing suitability of this device for data communication applications. An open eye diagram at the receiver output is presented with no pre-bias current applied and the VCSEL modulated at 155 Mbit/s demonstrating the possibility of direct logic-level drive.
Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE (2004)

The effect of HFE inactivation on iron homeostasis during an acute phase response was investigated in mice. HFE knockout, beta2-microglobulin knockout and C57BL/6J mice were injected with Freund's Complete Adjuvant to induce an acute phase response and hepatic hepcidin expression and serum transferrin saturation was determined 16 h later. Hepcidin mRNA increased in all strains in response to an acute phase stimulus when compared with untreated control animals. Hypoferraemia also occurred in all strains, indicating that both the upregulation of hepcidin and the decrease in transferrin saturation associated with an acute phase response is not dependent on HFE function.
A New Temperature Compensating Method for Logarithmic Amplifier (1970)

A new method of temperature compensation for a dc logarithmic amplifier is presented. By this method temperature effect on both parallel shift and slope variance of log I vs. VBE curve can be compensated easily by using only one compensating resistor of copper wire wound type. (hereafter called parallel and slope compensations.) An absolute compensation condition can be determined for each type of logarithmic transistors, like silicon NPN, germanium PNP irrespective of current measuring range. The temperature dependence of the logarithmic amplifier is reduced to 0.01 decade for the temperature range from 0°C to 50°C and the current range from 10-11 to 10-3A.
Learning bilingual translations from comparable corpora to cross-language information retrieval (2003)

Recent years saw an increased interest in the use and the construction of large corpora. With this increased interest and awareness has come an expansion in the application to knowledge acquisition and bilingual terminology extraction. The present paper will seek to present an approach to bilingual lexicon extraction from non-aligned comparable corpora, combination to linguisticsbased pruning and evaluations on Cross-Language Information Retrieval. We propose and explore a two-stages translation model for the acquisition of bilingual terminology from comparable corpora, disambiguation and selection of best translation alternatives on the basis of their morphological knowledge. Evaluations using a large-scale test collection on Japanese-English and different weighting schemes of SMART retrieval system confirmed the effectiveness of the proposed combination of two-stages comparable corpora and linguistics-based pruning on Cross-Language Information Retrieval.
<i>Deqi</i>Sensations of Transcutaneous Electrical Nerve Stimulation on Auricular Points (2013)

Deqi sensation, a psychophysical response characterized by a spectrum of different needling sensations, is essential for Chinese acupuncture clinical efficacy. Previous research works have investigated the component of Deqi response upon acupuncture on acupoints on the trunk and limbs. However, the characteristics of Deqi sensations of transcutaneous electrical nerve stimulation (TENS) on auricular points are seldom reported. In this study, we investigated the individual components of Deqi during TENS on auricular concha area and the superior scapha using quantitative measurements in the healthy subjects and depression patients. The most striking characteristics of Deqi sensations upon TENS on auricular points were tingling, numbness, and fullness. The frequencies of pressure, warmness, heaviness, and soreness were relatively lower. The dull pain and coolness are rare. The characteristics of Deqi were similar for the TENS on concha and on the superior scapha.
DDT, DDD, and DDE Dechlorination by Zero-Valent Iron (1997)

Traditionally, destruction of DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] for environmental remediation required high-energy processes such as incineration. Here, the capability of powdered zero-valent iron to dechlorinate DDT and related compounds at room temperature was investigated. Specifically, DDT, DDD [1,1-dichloro-2,2-bis(p-chlorophenyl)ethane], and DDE [2,2-bis(p-chlorophenyl)-1,1-dichloroethylene] transformation by powdered zero-valent iron in buffered anaerobic aqueous solution was studied at 20 °C, with and without the presence of nonionic surfactant Triton X-114. The iron was successful at dechlorinating DDT, DDD, and DDE. The rates of dechlorination of DDT and DDE were independent of the amount of iron, with or without surfactant. The rates with surfactant present were much higher than without. Initial first-order transformation rates for DDT, DDD, and DDE were determined. For example, the initial first-order rate of DDT dechlorination was 1.7 ± 0.4 and 3.0 ± 0.8 day-1 or, normalized by the specific iron surface area, 0.016 ± 0.004 and 0.029 ± 0.008 L m-2 h-1, without and with surfactant, respectively. A mechanistic model was constructed that qualitatively fit the observed kinetic data, indicating that the rate of dechlorination of the solid-phase (crystalline) reactants was limited by the rate of dissolution into the aqueous phase.
Automatic Detection of Phone-Based Anomalies in Dysarthric Speech (2015)

Perceptual evaluation is still the most common method in clinical practice for diagnosing and following the progression of the condition of people with speech disorders. Although a number of studies have addressed the acoustic analysis of speech productions exhibiting impairments, additional descriptive analysis is required to manage interperson variability, considering speakers with the same condition or across different conditions. In this context, this article investigates automatic speech processing approaches dedicated to the detection and localization of abnormal acoustic phenomena in speech signal produced by people with speech disorders. This automatic process aims at enhancing the manual investigation of human experts while at the same time reducing the extent of their intervention by calling their attention to specific parts of the speech considered as atypical from an acoustical point of view. Two different approaches are proposed in this article. The first approach models only the normal speech, whereas the second models both normal and dysarthric speech. Both approaches are evaluated following two strategies: one consists of a strict phone comparison between a human annotation of abnormal phones and the automatic output, while the other uses a “one-phone delay” for the comparison. The experimental evaluation of both approaches for the task of detecting acoustic anomalies was conducted on two different corpora composed of French dysarthric speakers and control speakers. These approaches obtain very encouraging results and their potential for clinical uses with different types of dysarthria and neurological diseases is quite promising.
Acute Corneal Endothelial Changes After Laser In Situ Keratomileusis (2001)

Qualitative and quantitative changes in endothelial cell morphology (i.e., decreased endothelial cell hexagonality) demonstrate that LASIK does induce an acute effect on the corneal endothelium that may represent transient endothelial cell edema.
The CAPIO 2017 Conversational Speech Recognition System (2017)

In this paper we show how we have achieved the state-of-the-art performance on the industry-standard NIST 2000 Hub5 English evaluation set. We explore densely connected LSTMs, inspired by the densely connected convolutional networks recently introduced for image classification tasks. We also propose an acoustic model adaptation scheme that simply averages the parameters of a seed neural network acoustic model and its adapted version. This method was applied with the CallHome training corpus and improved individual system performances by on average 6.1% (relative) against the CallHome portion of the evaluation set with no performance loss on the Switchboard portion. With RNN-LM rescoring and lattice combination on the 5 systems trained across three different phone sets, our 2017 speech recognition system has obtained 5.0% and 9.1% on Switchboard and CallHome, respectively, both of which are the best word error rates reported thus far. According to IBM in their latest work to compare human and machine transcriptions, our reported Switchboard word error rate can be considered to surpass the human parity (5.1%) of transcribing conversational telephone speech.
A role for microtubules in sorting endocytic vesicles in rat hepatocytes. (1992)

The vectorial nature of hepatocyte receptor-mediated endocytosis (RME) and its susceptibility to cytoskeletal disruptors has suggested that a polarized network of microtubules plays a vital role in directed movement during sorting. Using as markers a well-known ligand, asialoorosomucoid, and its receptor, we have isolated endocytic vesicles that bind directly to and interact with stabilized endogenous hepatocyte microtubules at specific times during a synchronous, experimentally initiated, single wave of RME. Both ligand- and receptor-containing vesicles copelleted with microtubules in the absence of ATP but did not pellet under similar conditions when microtubules were not polymerized. When 5 mM ATP was added to preparations of microtubule-bound vesicles, ligand-containing vesicles were released into the supernatant, while receptor-containing vesicles remained immobilized on the microtubules. Release of ligand-containing vesicles from microtubules was prevented by monensin treatment during the endocytic wave. Several proteins, including the microtubule motor protein cytoplasmic dynein, were present in these preparations and were released from microtubule pellets by ATP addition concomitantly with ligand. These results suggest that receptor domains within the endosome can be immobilized by attachment to microtubules so that, following monensin-sensitive dissociation of ligand from receptor, ligand-containing vesicles can be pulled along microtubules away from the receptor domains by a motor molecule, such as cytoplasmic dynein, thereby delineating sorting.
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception (2011)

Computational methods have led two groups to predict the endogenous presence of a highly conserved, amidated, 14-aa neuropeptide called either spexin or NPQ. NPQ/spexin is part of a larger prohormone that contains 3 sets of RR residues, suggesting that it could yield more than one bioactive peptide; however, no in vivo activity has been demonstrated for any peptide processed from this precursor. Here we demonstrate biological activity for two peptides present within proNPQ/spexin. NPQ/spexin (NWTPQAMLYLKGAQ-NH(2)) and NPQ 53-70 (FISDQSRRKDLSDRPLPE) have differing renal and cardiovascular effects when administered intracerebroventricularly or intravenously into rats. Intracerebroventricular injection of NPQ/spexin produced a 13 ± 2 mmHg increase in mean arterial pressure, a 38 ± 8 bpm decrease in heart rate, and a profound decrease in urine flow rate. Intracerebroventricular administration of NPQ 53-70 produced a 26 ± 9 bpm decrease in heart rate with no change in mean arterial pressure, and a marked increase in urine flow rate. Intraventricular NPQ/spexin and NPQ 53-70 also produced antinociceptive activity in the warm water tail withdrawal assay in mice (ED(50)<30 and 10 nmol for NPQ/spexin and NPQ 53-70, respectively). We conclude that newly identified peptides derived from the NPQ/spexin precursor contribute to CNS-mediated control of arterial blood pressure and salt and water balance and modulate nociceptive responses.
Radiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines (2014)

TAS-102 (trifluorothymidine [TFT] and thymidine phosphorylase inhibitor [TPI] in a molar ratio of 1:0.5) has activity in 5-fluorouracil resistant colon cancer. TPI is added to increase TFT's bioavailability. TFT has a dual mechanism of action by inhibiting thymidylate synthase and by its incorporation into DNA. Interesting radiosensitizing effects of TPI were recently reported. The aim of our study was to determine whether TP expression would affect radiosensitivity and to characterize the effect of TPI. Two bladder cancer cell lines RT112 (TP negative) and RT112/TP (TP overexpression) were tested for drug sensitivity and radiosensitivity (clonogenic assay), with and without TFT and/or TPI. Expression of γ H2AX was used as marker for DNA damage. RT112 cells were not more sensitive to TFT then RT112/TP cells. TPI alone did not inhibit cell growth of RT112 even at 100 μM, but inhibited that of RT112/TP by 27%. In both RT112 and RT112/TP cells 10 μM TPI did not or slightly affect radiosensitivity, but 100 μM TPI alone enhanced the radiation response (p<.05). TFT alone at 1 μM and in combination with 10 μM TPI did not affect the radiation response of both cell lines. TPI alone induced expression of ϒH2AX, which was increased in combination with radiation. In conclusion, TPI enhanced radiosensitivity at high concentrations, independent of TP expression, while TFT and TPI at a low concentration did not affect the radiosensitivity of RT112 and RT112/TP cell lines.
Tenocytes from Ruptured and Tendinopathic Achilles Tendons Produce Greater Quantities of Type III Collagen than Tenocytes from Normal Achilles Tendons: An in Vitro Model of Human Tendon Healing (2000)

Type I collagen is the main collagen in tendons; type III collagen is present in small amounts. Ruptured Achilles tendons contain a significantly greater proportion of type Ill collagen, which predisposes them to rupture. We used an in vitro model to determine whether tenocytes from Achilles tendons that were ruptured (N = 22), nonruptured (N = 7), tendinopathic (N = 12), and fetal (N = 8) show different behavior. Samples of Achilles tendon were digested with collagenase and the released tenocytes were collected. Primary tenocyte cultures were established and subsequently cultured onto glass coverslips. Once a confluent monolayer was obtained, the cell populations were "wounded" by scraping a pipette tip along the surface. The cultures were further incubated for either 1, 4, 8, 12, 16, or 24 hours, and production of types I and II collagen was assessed by immunostaining. In cultures from ruptured and tendinopathic tendons, there was increased production of type Ill collagen. Athletic participation places excess stress on the Achilles tendon, which could potentially lead to areas of microtrauma within the tendon. These areas may heal by the production of type III collagen, which is an abnormal healing response. Accumulation of such episodes of microtrauma could resuit in a critical point where the resistance of the tissue to tensile forces is compromised and tendon rupture occurs.
Biochemistry and rheology of sputum in asthma (1971)

Journal Article Biochemistry and rheology of sputum in asthma Get access E E Keal, M.B., M.R.C.P., D.C.H E E Keal, M.B., M.R.C.P., D.C.H Senior Lecturer Consultant Physician, Brompton Hospital, Department of Experimental Pathology, Institute of Diseases of the Chest Search for other works by this author on: Oxford Academic Google Scholar Postgraduate Medical Journal, Volume 47, Issue 545, March 1971, Pages 171–177, https://doi.org/10.1136/pgmj.47.545.171 Published: 01 March 1971
Electrochemical Photocapacitance Spectroscopy: A New Method for Characterization of Deep Levels in Semiconductors (1982)

Electrochemical photocapacitance spectroscopy (EPS) offers advantages over similar solid-state photocapacitance spectroscopic techniques. In the EPS method, the capacitance of a reverse-biased semiconductor electrode is measured as a function of the wavelength of incident sub-bandgap light. In the present work, EPS is shown to be an extremely sensitive means for characterizing deep levels in semiconductor materials. For horizontal Bridgeman-grown n-GaAs, a hole trap, the chromium phototransition, and two electron traps were detected. The energies and densities of states for these levels correspond well with values reported in the literature for solid-state studies of similar materials. 21 refs.
Fermentations with New Recombinant Organisms (1999)

United States fuel ethanol production in 1998 exceeded the record production of 1.4 billion gallons set in 1995. Most of this ethanol was produced from over 550 million bushels of corn. Expanding fuel ethanol production will require developing lower-cost feedstocks, and only lignocellulosic feedstocks are available in sufficient quantities to substitute for corn starch. Major technical hurdles to converting lignocellulose to ethanol include the lack of low-cost efficient enzymes for saccharification of biomass to fermentable sugars and the development of microorganisms for the fermentation of these mixed sugars. To date, the most successful research approaches to develop novel biocatalysts that will efficiently ferment mixed sugar syrups include isolation of novel yeasts that ferment xylose, genetic engineering of Escherichia coli and other gram negative bacteria for ethanol production, and genetic engineering of Saccharoymces cerevisiae and Zymomonas mobilis for pentose utilization. We have evaluated the fermentation of corn fiber hydrolyzates by the various strains developed. E. coli K011, E. coli SL40, E. coli FBR3, Zymomonas CP4 (pZB5), and Saccharomyces 1400 (pLNH32) fermented corn fiber hydrolyzates to ethanol in the range of 21-34 g/L with yields ranging from 0.41 to 0.50 g of ethanol per gram of sugar consumed. Progress with new recombinant microorganisms has been rapid and will continue with the eventual development of organisms suitable for commercial ethanol production. Each research approach holds considerable promise, with the possibility existing that different "industrially hardened" strains may find separate applications in the fermentation of specific feedstocks.
Three-dimensional DNA image cytometry by confocal scanning laser microscopy in thick tissue blocks of prostatic lesions (1997)

DNA ploidy provides important information for the evaluation of the prognosis of prostate cancer. For the purpose of DNA cytometry and nuclear measurements, we developed an image processing system for the acquisition and processing of three-dimensional (3D) images based on confocal scanning laser microscopy (CSLM). The advantage of the CSLM is the preservation of the tissue architecture and the possibility of multilabeling. It is possible to determine both individual nuclear features and cellular features and the degree of the spatial heterogeneity of several markers. Special attention was paid to the development of the automatic method for the 3D segmentation of cell nuclei. Thick tissue slides (100 microm), stained for DNA with chromomycin A3, from 4 patients (with benign hyperplasia, prostatic intraepithelial neoplasia (PIN), and well-and poorly-differentiated adenocarcinoma of the prostate), were studied in order to test the practicability of the developed methodology. DNA histograms showed a single peak in the diploid range for the hyperplasia and PIN cases. For the case of well-differentiated carcinoma, 2 peaks were observed, 1 in the diploid range and I in the tetraploid range. The case of poorly-differentiated carcinoma was characterized by an aneuploid distribution. For the cases of PIN and carcinomas, we observed a considerable variation of the volume of nuclei.
Regularized image up-sampling (2004)

This thesis addresses the problem of performing image magnification to achieve higher perceived resolution for grey-scale and color images. A new perspective on the problem is introduced through the new concept of a theoretical camera that can acquire an ideal high resolution image. A new formulation of the problem is then introduced using two ingredients: a newly designed observation model and the total-variation regularizer. An observation model, that establishes a generalized relation between the desired magnified image and the measured lower resolution image, has been newly designed based on careful study of the physical acquisition processes that have generated the images. The result is a major contribution of this thesis: a closed-form solution for obtaining the observation model. This closed form has been implemented and observation models were obtained for different typical scenarios, and their performance was shown to outperform observation models used in the literature. Two new theorems for designing the theoretical camera, adapted to the display device used, on arbitrary lattices have been developed. The thesis presents new analysis with a signal processing perspective that justifies the use of the total-variation regularizer as a priori knowledge for the magnified image; this analysis is defined on both the low and the high resolution lattices simultaneously. The resulting objective function has been minimized numerically using the level-set method with two new motions that interact simultaneously, leading to a solution scheme that is not trapped in constant-image solutions and converges to a unique solution regardless of the initial estimate. For color images, the human visual system characteristics were involved in the choice of the color space used in the implementation. It was found that a proper color space such as YCbCr that focuses on magnifying a better luminance channel provided the same result as a vectorial total-variation formulation, but at a reduced computational cost. The quality of the magnified images obtained by the new approaches of this thesis surpassed the quality of state-of-the-art methods from the literature.
Codon usage tabulated from the GenBank Genetic Sequence Data (1988)

Journal Article Codon usage tabulated from the GenBank Genetic Sequence Data Get access Shin-ichi Aota, Shin-ichi Aota National Institute of GeneticsMishmia, 411, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Gojobori, Takashi Gojobori National Institute of GeneticsMishmia, 411, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Fumie Ishibashi, Fumie Ishibashi National Institute of GeneticsMishmia, 411, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Takeo Maruyama, Takeo Maruyama National Institute of GeneticsMishmia, 411, Japan *It is with great sorrow that we have to infom you of Dr. Maruyama's sudden death. He died of a heart attack on December 11 in 1987. Thus, this paper became his posthumous work. We express our condolences to his family. Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshimichi Ikemura Toshimichi Ikemura National Institute of GeneticsMishmia, 411, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue suppl, 1 January 1988, Pages r315–r402, https://doi.org/10.1093/nar/16.suppl.r315 Published: 01 January 1988
Infrared microantennas (1997)

We present results of measurements of the polarization response of asymmetric spiral antennas coupled to Ni-NiO-Ni diodes, over the wavelength range 10.2 to 10.7 tim. The feed structure of the antenna imposes an elliptical polarization signature that is different from the circular polarization expected from a symmetric spiral. We develop a lossy-transmission-line model yielding the measured polarization response. A combination of a balanced and an unbalanced mode is required. Reflected current waves from the arm ends are significant.