gebhart/patrepeval huggingface dataset:
The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation (2012)

Anti-inflammatory therapeutic options for the topical treatment of skin diseases with inflammatory or allergic contribution are mostly limited to topical glucocorticoids and calcineurin inhibitors. Both compound classes induce adverse effects. Elevation of intracellular cyclic adenosine monophosphate (cAMP) by inhibition of phosphodiesterase 4 was shown to induce potent anti-inflammatory effects, but the safety profile of currently available compounds is not sufficient. A different approach to increase intracellular cAMP is the substitution of chemically stabilized cAMP analogues. Bucladesine is a stabilized cAMP analogue with an excellent safety profile which had been marketed as topical treatment of impaired wound healing. In the current study, a novel water free emulsion containing bucladesine was evaluated for anti-inflammatory effects. In the arachidonic acid induced ear oedema model in mice, single or multiple administration of an emulsion containing 1.5% was capable of significantly reducing the inflammatory oedema. The data indicate that bucladesine represents an interesting treatment option for skin diseases where an anti-inflammatory activity is indicated. Due to the established clinical safety, this agent may bridge the gap between potent agents such as glucocorticoids or calcineurin inhibitors and emollients without active compounds.
Diffusion of hydrogen in metal membranes deformed in tension (1984)

Three well known electrochemical techniques were used to study the diffusion of hydrogen in tensilely deformed iron and nickel membranes. Constant current permeation tests, current pulse tests and potentiostatic depletion tests were performed to determine which test produced the most reliable and reproduceable data. The bulk lattice diffusivity in annealed nickel at 22°C was found to be 3.24 X 1 cm2/sec while the bulk lattice diffusivity in annealed iron at 21°C was found to be 1.59 X 1”6 cm2/sec.
Active Disturbance Rejection Control for Server Storage System Temperature Regulation (2018)

Reducing the energy consumption for cooling in servers is a major challenge considering data center energy costs today as the power used to cool the servers has become an increasingly large component of the total power consumption. This paper presents an active disturbance rejection control based decoupling control algorithm for flash storage system in a one-unit server to simultaneously improve fan power consumption efficiency and regulate the server SSDs’ temperature to avoid downgraded performance caused by overheating. In the study, a benchmark system is established based on the Samsung Mission Peak server where the thermal characteristics and existing solutions are both systematically evaluated. Good performance of reducing throttling rate and saving fan power were attained in two case studies involving when the drive-zones are partially idle and when they are fully loaded with significant uncertain workload disturbances.
miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway (2015)

The present study identified and characterised a signalling pathway, the miR-367/Smad7-TGF-β pathway, which is involved in the invasion and metastasis of pancreatic cancer cells. Our results suggest that miR-367 may be a promising therapeutic target for the treatment of human pancreatic cancer.
Broadband LEO Constellations for Navigation (2018)

There has been resurgent interest in building low Earth orbiting (LEO) constellations of satellites on a new scale. Their aim is Internet for the world with plans for potentially thousands of satellites. Here, we explore how these LEO constellations can be utilized for navigation. Closer to Earth, LEO offers stronger signals, strengthening us against jamming and aiding in indoor and urban environments. Proximity is also its weakness, where satellites have a small Earth footprint requiring many to provide global coverage. We show that the strength of the Broadband LEO constellations is their numbers, where they offer threefold improvement in satellite geometry compared to navigation core-constellations today. This allows for relaxation of the signal-in-space user range error, while still matching the position accuracy of GPS. Coupled with the more benign radiation environment in LEO compared to GPS in medium Earth orbit, this enables a navigation payload designed using commercial-off-the-shelf components. © 2018 Institute of Navigation
Patterned artificial juxtacrine stimulation of cells by covalently immobilized insulin (1997)

Insulin was immobilized on prescribed areas of poly(ethylene terephthalate) film by photolithography. Chinese hamster ovary cells overexpressing human insulin receptors were cultured on the pattern-immobilized film. Pattern-immobilized insulin did not enhance cell adhesion but transduced a signal to the cells through phosphorylation of tyrosine residues of signal proteins. In addition, only cells on immobilized insulin grew in medium containing no serum. The enhancement of cell growth was considered to be a consequence of signal transduction. This microprocessing technique is useful for investigating the effect of immobilized biosignal molecules and for constructing new tissue engineering materials.
Modulation of the Viral ATPase Activity by the Portal Protein Correlates with DNA Packaging Efficiency (2006)

DNA packaging in tailed bacteriophages and herpesviruses requires assembly of a complex molecular machine at a specific vertex of a preformed procapsid. As in all these viruses, the DNA translocation motor of bacteriophage SPP1 is composed of the portal protein (gp6) that provides a tunnel for DNA entry into the procapsid and of the viral ATPase (gp1-gp2 complex) that fuels DNA translocation. Here we studied the cross-talk between the components of the motor to control its ATP consumption and DNA encapsidation. We showed that gp6 embedded in the procapsid structure stimulated more than 10-fold the gp2 ATPase activity. This stimulation, which was significantly higher than the one conferred by isolated gp6, depended on the presence of gp1. Mutations in different regions of gp6 abolished or decreased the gp6-induced stimulation of the ATPase. This effect on gp2 activity was observed both in the presence and in the absence of DNA and showed a strict correlation with the efficiency of DNA packaging into procapsids containing the mutant portals. Our results demonstrated that the portal protein has an active control over the viral ATPase activity that correlates with the performance of the DNA packaging motor.
Detection of potential fractures and small faults using seismic attributes (2004)

Often it is difficult to map subtle faults and other trace-to-trace discontinuities hidden in 3D seismic data. They may appear as minor changes in the seismic waveform that are not easily correlated using conventional interpretation of seismic cross-sections. To map these changes we have investigated and computed several different seismic attributes sensitive to the existence of small faults and fractures in our target reservoir, the Late Permian Unayzah sandstone of central Saudi Arabia. In addition to the traditional geometric horizon attributes such as dip and azimuth, we found that both coherence and spectral decomposition were useful in imaging seismic discontinuities.
Applications of the 1-D diffusion approximation to the optics of tissues and tissue phantoms (1989)

Optical constants of animal and plant tissues were measured over a wide spectral range using an integrating sphere spectrophotometer. The data were analyzed with two formulations of the 1-D diffusion approximation differing in the phase function. The accuracy of the similarity transformation was examined with tissue phantoms incorporating known chromophores in light scattering media.
Analysis of Frequency Mismatch in Narrowband Active Noise Control (2009)

This paper analyzes the effects of frequency mismatch between the actual frequency of the primary noise and the frequency of the synthesized reference signal in narrowband active noise control (ANC) systems using the filtered-X least-mean-square (FXLMS) algorithm. Two stability conditions are derived in terms of the frequency mismatch and the phase error of the estimated secondary-path model. Conditions to guarantee that ANC systems can achieve noise reduction are also developed by considering the overall effect of frequency mismatch and phase error. The optimum step-size to reach the minimum excess mean-square error is obtained and analyzed. Theoretical analysis shows that the noise reduction and convergence rate are functions of frequency mismatch, step size, and phase error in the secondary-path model for the FXLMS algorithm. Computer simulations are conducted to verify the analysis results presented in the paper.
The development of improved ultrasound heaters suitable for superficial tissue heating (1982)

The acoustical fields generated by several ultrasound heaters have been measured to determine their suitability for heating superficial lesions in cancer patients. Three different acoustical sensors were used in the study, and one sensor, consisting of a thermocouple embedded in a sound-absorbing plastic, proved to be the most practical device for routine use. The method employed to mount the piezoelectric crystal in the heater was found to have a profound effect on the acoustical field generated by the heater. Clamping the crystal close to its edge resulted in a field with a prominent acoustical maxima on the crystal axis. A flexible attachment at the very edge of the crystal resulted in a much more uniform field which could be further improved by rapidly sweeping the frequency of the signal used to excite the piezoelectric crystal. A heater in which the rear electrode of the piezoelectric crystal is sectioned into a series of concentric rings has also been developed. This heater can deposit more acoustical energy at the edges of a treatment volume than at the center, and the diameter of the ultrasound beam can also be adjusted. The results demonstrate that (i) the acoustical fields of ultrasound heaters must be accurately measured before using the heaters clinically, and that (ii) by careful design, both uniform or controlled nonuniform acoustical fields can be generated.
Serial measurements of CT attenuation and specific gravity in experimental cerebral edema. (1980)

Vasogenic cerebral edema was induced cryogenically in rhesus monkeys. Serial scans in both axial and coronal planes were used to study the onset, peak, and regression of edema. Progression of edema, predominantly involving the white matter, was analyzed from the postmortem distribution of a blood/brain barrier indicator (Evans blue) injected at surgery. Specific gravity was measured in fresh, unfixed specimens from both the edematous and normal hemispheres and correlated with corresponding CT attenuation values obtained before death. The drop in specific gravity closely corresponded to the decrease in CT attenuation.
Multiprocessor join scheduling (1993)

A practical join processing strategy that allows effective utilization of arbitrary degrees of parallelism in both the I/O subsystem and join processing subsystems is presented. Analytic bounds on the minimum execution time, minimum number of processors, and processor utilization are presented along with bounds on the execution time, given a fixed number of processors. These bounds assume that sufficient buffers are available. An analytic lower bound on buffer requirements as well as a practical heuristic for use in limited buffer environments are also presented. A sampling of corroborative simulation results are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
CALENDAR OF MANUSCRIPTS (<i>continued</i>) (2010)

184. [1586.] “An acte for the restitution of Christian discipline in the Churche of England, and for the abolishing of the Cannon Lawe in that behalfe.”
Substituted Bromoquinolines<sup>1</sup> (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted Bromoquinolines1C. E. Kaslow and William R. LawtonCite this: J. Am. Chem. Soc. 1950, 72, 4, 1723–1724Publication Date (Print):April 1, 1950Publication History Published online1 May 2002Published inissue 1 April 1950https://pubs.acs.org/doi/10.1021/ja01160a083https://doi.org/10.1021/ja01160a083research-articleACS PublicationsRequest reuse permissionsArticle Views265Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Safety checking of machine code (2000)

We show how to determine statically whether it is safe for untrusted machine code to be loaded into a trusted host system. Our safety-checking technique operates directly on the untrusted machine-code program, requiring only that the initial inputs to the untrusted program be annotated with typestate information and linear constraints. This approach opens up the possibility of being able to certify code produced by any compiler from any source language, which gives the code producers more freedom in choosing the language in which they write their programs. It eliminates the dependence of safety on the correctness of the compiler because the final product of the compiler is checked. It leads to the decoupling of the safety policy from the language in which the untrusted code is written, and consequently, makes it possible for safety checking to be performed with respect to an extensible set of safety properties that are specified on the host side. We have implemented a prototype safety checker for SPARC machine-language programs, and applied the safety checker to several examples. The safety checker was able to either prove that an example met the necessary safety conditions, or identify the places where the safety conditions were violated. The checking times ranged from less than a second to 14 seconds on an UltraSPARC machine.
A facile conversion of the phenylthio group to acetoxy by copper reagents for a practical synthesis of 4-acetoxyazetidin-2-one derivatives from (R)-butane-1,3-diol (1991)

(3S,4R,1′R)-4-Acetoxy-3-(1′-tert-butyldimethylsilyloxyethyl)-azetidin-2-one 8, an important intermediate for the synthesis of penem and carbapenem antibiotics, was synthesized from (R)-butane-1,3-diol 1, using chlorosulphonyl isocyanate for the formation of β-lactam ring in which a significant solvent effect on the ratio of diastereoisomers 6a and 6b was observed; copper(II) acetate rather than the poisonous mercury(II) acetate was used to convert the phenylthio group of compound 6a to acetoxy.
A new dawn (2001)

AT times it has seemed like a secret society. During the past few months a small group, including two primary school teachers with a special interest in key stage 1, has been meeting during cold winter evenings to plot and plan the creation of a new magazine aimed specifically at teachers of five-to-sevens. The result is what you see today.
Hormone-induced Recruitment of Sp1 Mediates Estrogen Activation of the Rabbit Uteroglobin Gene in Endometrial Epithelium (1998)

Steroid hormones activate gene expression by interaction of their receptors with hormone-responsive DNA elements and tissue-specific or ubiquitous factors. To monitor the molecular changes on the promoter of the rabbit uteroglobin gene during early pseudopregnancy in vivo, we have applied the genomic footprinting methodology to endometrial tissue. Estrogen induction results in the simultaneous occupancy of an estrogen-responsive element and an adjacent GC/GT box in the promoter. DNA binding assays demonstrate that the corresponding regulatory factors are the ligand-induced estrogen receptor and the ubiquitous transcription factor Sp1. Both factors functionally synergize in primary endometrial cells, showing that the GC/GT box is an essential part of a composite estrogen-responsive unit. However, the estrogen receptor and Sp1 do not bind cooperatively to their sites in vitro, suggesting that other mechanisms might be responsible for the hormone-dependent binding of Sp1 in vivo. Since hormone treatment leads to the appearance of a distinct DNase I-hypersensitive site over the promoter chromatin, an estrogen-induced change in the local chromatin structure could facilitate binding of Sp1 in vivo.
Cover Image (2020)

The cover image is based on the Original Contribution A multi-center, open-label, pilot study of allograft adipose matrix for the correction of atrophic temples by Michael H. Gold et al., https://doi.org/10.1111/jocd.13363.
Vernier-cascade label-free biosensor with integrated arrayed waveguide grating for wavelength interrogation with low-cost broadband source (2011)

Recently, cheap silicon-on-insulator label-free biosensors have been demonstrated that allow fast and accurate quantitative detection of biologically relevant molecules for applications in medical diagnostics and drug development. However, whereas the sensor chip can be made cheaply, an expensive tunable laser is typically required to accurately monitor spectral shifts in the sensor's transmission spectrum (wavelength interrogation). To address this issue, we integrated a very sensitive Vernier-cascade sensor with an arrayed waveguide grating spectral filter that divides the sensor's transmission spectrum in multiple wavelength channels and transmits them to spatially separated output ports, allowing wavelength interrogation with a much cheaper broadband light source. Experiments show that this sensor can monitor refractive index changes of watery solutions in real time with a detection limit (1.6·10(-5) RIU) competitive with more expensive interrogation schemes, indicating its applicability in low-cost label-free biosensing. The relaxation on the complexity of the source, moreover, offers the prospect to integrate the source and detectors to further reduce the device cost and to increase its portability.
Curcumin Enhances the Effect of Cisplatin in Suppression of Head and Neck Squamous Cell Carcinoma via Inhibition of IKKβ Protein of the NFκB Pathway (2010)

Previous experiments have shown that curcumin or cisplatin treatment suppresses growth of head and neck squamous cell carcinoma (HNSCC). To study the potential cooperative effect of both agents, two HNSCC cell lines were treated with curcumin or cisplatin alone or in combination. In vivo studies consisted of intravenous tail vein injection of liposomal curcumin, with intraperitoneal cisplatin, into nude mice growing xenograft HNSCC tumors. Introduction of curcumin and suboptimal concentrations of cisplatin showed a significant suppressive effect compared with treatment with either agent alone. Reduced expression of cyclin D1, IκBα, phospho-IκBα, and IKKβ occurred in cisplatin- and curcumin-treated cell lines. Confocal microscopy showed expression of IKKβ in the nucleus of the cell lines. Chromatin immunoprecipitation assay on DNA isolated from IKKβ immunoprecipitated samples showed PCR amplification of interleukin-8 promoter sequences, a binding site of NFκB, indicating an interaction between IKKβ and NFκB. Curcumin inhibited IKKβ in the cytoplasm and nucleus, leading to reduced NFκB activity, with no effect on phospho-AKT. In vivo studies showed significant growth inhibition of xenograft tumors treated with a combination of liposomal curcumin and cisplatin. The suppressive effect of curcumin was mediated through inhibition of cytoplasmic and nuclear IKKβ, resulting in inhibition of NFκB activity. Cisplatin treatment led to cellular senescence, indicating an effect mediated by p53 activation. The mechanisms of the two agents through different growth signaling pathways suggest potential for the clinical use of subtherapeutic doses of cisplatin in combination with curcumin, which will allow effective suppression of tumor growth while minimizing the toxic side effects of cisplatin.
Investigations of the Effects of Gender, Diurnal Variation, and Age in Human Urinary Metabolomic Profiles (2007)

Metabolomics may have the capacity to revolutionize disease diagnosis through the identification of scores of metabolites that vary during environmental, pathogenic, or toxicological insult. NMR spectroscopy has become one of the main tools for measuring these changes since an NMR spectrum can accurately identify metabolites and their concentrations. The predominant approach in analyzing NMR data has been through the technique of spectral binning. However, identification of spectral areas in an NMR spectrum is insufficient for diagnostic evaluation, since it is unknown whether areas of interest are strictly caused by metabolic changes or are simply artifacts. In this paper, we explore differences in gender, diurnal variation, and age in a human population. We use the example of gender differences to compare traditional spectral binning techniques (NMR spectral areas) to novel targeted profiling techniques (metabolites and their concentrations). We show that targeted profiling produces robust models, generates accurate metabolite concentration data, and provides data that can be used to help understand metabolic differences in a healthy population. Metabolites relating to mitochondrial energy metabolism were found to differentiate gender and age. Dietary components and some metabolites related to circadian rhythms were found to differentiate time of day urine collection. The mechanisms by which these differences arise will be key to the discovery of new diagnostic tests and new understandings of the mechanism of disease.
Synthesis and Antimycobacterial Activity of Pyridylmethylsulfanyl and Naphthylmethylsulfanyl Derivatives of Benzazoles, 1,2,4‐Triazole, and Pyridine‐2‐carbothioamide/‐2‐carbonitrile. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.