gebhart/patrepeval huggingface dataset:
A Managerial Approach to Advertising Measurement (1965)

This article is based on the findings of a continuing study of advertising measurement that the author is conducting under the auspices of the Planning and Evaluation Committee of the Association of National Advertisers. Since the time that the study started in 1963, data on advertising measurements have been secured from 1,225 individuals in 414 firms in the United States and Canada, and case-history data have been gathered from 50 of these companies. The completed study, to be published in book form, will give case histories of the attempts of national advertisers to measure advertising results — with annual advertising expenditures ranging from under $500,000 to over $50,000,000. One or more case histories from each of the following categories will be included: (1) industrial goods and services, (2) consumer durable goods, (3) consumer nondurable goods, (4) consumer services.
Heterogeneities in vertebrate tRNAs<sup>Trp</sup>Avian retroviruses package only as a primer the tRNA<sup>Trp</sup>lacking modified m2G in positon 7 (1990)

Bovine, rabbit and chicken tRNA(Trp) species and tRNA(Trp) packaged in avian myeloblastosis virus were separated and purified using two-dimensional gel electrophoresis and their primary structures were determined. Two major tRNA(Trp) species (1 and 2) were identified in beef and rabbit, two minor ones (3 and 4) in beef and only one minor in rabbit. Their structures differ by 4 nucleotide substitutions located in the D, S and T loops (positions 16, 47, 57 and 59). Species 3 and 4 differ from one another by only one nucleotide at position 2. Differences between tRNA(Trp) species were also observed in the extent of methylation of some nucleotides. Chicken tRNA(Trp) presents only one species similar to the mammalian type 1 tRNA(Trp). In the case of the three studies animals this tRNA could be separated into two subspecies, which differ by a post-transcriptional modification of nucleotide 7 in the acceptor stem: G or m2G. However only the nonmethylated species is used as the primer of DNA-RNA directed retrotranscription since it is only that form which was found in avian retroviruses. The methylation of G to m2G at position 7 could thus prevent the recognition of tRNA(Trp) by retroviral protein(s) responsible for the selective packaging of the primer tRNA(Trp).
Inactivation of Staphylococcus aureus and Salmonella enteritidis in tryptic soy broth and caviar samples by high pressure processing (2005)

We studied the action of high pressure processing on the inactivation of two foodborne pathogens, Staphylococcus aureus ATCC 6538 and Salmonella enteritidis ATCC 13076, suspended in a culture medium and inoculated into caviar samples. The baroresistance of the two pathogens in a tryptic soy broth suspension at a concentration of 10(8)-10(9) colony-forming units/ml was tested for continuous and cycled pressurization in the 150- to 550-MPa range and for 15-min treatments at room temperature. The increase of cycle number permitted the reduction of the pressure level able to totally inactivate both microorganisms in the tryptic soy broth suspension, whereas the effect of different procedure times on complete inactivation of the microorganisms inoculated into caviar was similar.
Pontomedullary Tears and Other Gross Brainstem Injuries after Vehicular Accidents (1989)

In a series of 988 autopsied victims of road crashes, there were 36 (3.6%) cases of gross primary brainstem injury. These fell into three groups. The first comprised eight cases of pontomedullary tearing without other gross brain injury: in seven of these, there were associated atlanto-occipital dislocations and/or high cervical fracture-dislocations. The usual cause appeared to be facial impact inducing acute hyperextension. Second, there were 17 cases of pontomedullary tearing associated with other brainstem lacerations and/or major damage elsewhere in the brain: in all, there were fractures of the skull base, typically transverse middle fossa fractures. Most of these injuries appeared to be due to facial impacts transmitting force to the anterior skull base, although hyperextension was also a factor in some. There was a third heterogeneous group of 11 cases with brainstem lacerations in sites other than the pontomedullary junction: in some of these it appeared that the impacts had caused skull base fractures by inducing calvarial torsion. In this series, the proportion of motorcyclists (41.7%) was double the expected figure. The use of a helmet modifies the mechanisms of impact head injury; the overall benefits of helmet use are well established, but there is need for more research on helmet design.
Linear Dynamics and Stability Analysis of a Two-Craft Coulomb Tether Formation (2006)

The linearized dynamics and stability of a two-craft Coulomb tether formation is investigated. With a Coulomb tether the relative distance between two satellites is controlled using electrostatic Coulomb forces. A charge feedback law is introduced to stabilize the relative distance between the satellites to a constant value. Compared to previous Coulomb thrusting research, this is the first feedback control law that stabilizes a particular formation shape. The two craft are connected by an electrostatic tether that is capable of both tensile and compressive forces. As a result, the two-craft formation will essentially act as a long, slender near-rigid body. Interspacecraft Coulomb forces cannot influence the inertial angular momentum of this formation. However, the differential gravitational attraction can be exploited to stabilize the attitude of this Coulomb tether formation about an orbit nadir direction. Stabilizing the separation distance will also stabilize the in-plane rotation angle, whereas the out-of-plane rotational motion remains unaffected. The Coulomb tether has been modeled as a massless, elastic component. The elastic strength of this connection is controlled through a spacecraft charge control law.
The effect of heat on beef aroma: Comparisons of chemical composition and sensory properties (1986)

Abstract Aroma volatiles of fresh cooked ground beef subjected to varying degrees of heating were adsorbed on to Tenax TA, and the desorbed aromas analysed sensorially‐and chemically. Cooked meaty character, when present, was being sampled on to the Tenax and desorbed from it under the analytical conditions used. Several of the components identified by combined capillary gas chromatography‐mass spectrometry have not been reported previously from heated beef. Data is presented to support the generalization that the higher the degree of heating, the greater the concentrations of aliphatic aldehydes (especially Strecker aldehydes), benzenoids, aliphatic polysulphides, heterocyclic compounds and lipid‐derived volatiles, whilst smaller contributions to the isolates arise from aliphatic ketones and alcohols (of non‐lipid origin) and aliphatic mono‐sulphur components. By sensory analysis, eight odour qualities were frequently used during gas chromatographic odour port assessment, namely buttery, caramel, burnt, green, fragrant, oily/fatty, nutty and meaty. Components associated with the former seven qualities are aroma modifiers whereas compounds contributing meaty quality are character impact compounds, e.g. 2‐methyl‐3‐(methylthio)furan and 3‐methylcyclopentanone. Additionally, several unsaturated alicyclic ketones were present which resemble the cyclohexenones previously known to be significant in meat aroma.
Preparation of multi-arm star polymers with polylithiated carbosilane dendrimers (1998)

Polyfunctional dendrimers are empolyed for the synthesis of multi-arm star-shaped polymers. Terminal allyl groups of a carbosilane dendrimer have been partly extended by hydrosilylation-addition of didecylmethylsilane and partly lithiated by reaction with butyllithium. Due to the peculiar structure of the dendritic polylithium compounds, the carbanionic sites were screened from intermolecular interaction and did not aggregate. Good solubility and accessibility for different monomers allowed the preparation of new star-branched poly(dimethylsiloxane), polystyrene and poly(ethylene oxide) polymers.
A novel mutation within a transmembrane helix of the bile salt export pump (<scp>BSEP</scp>,<i><scp>ABCB</scp>11</i>) with delayed development of cirrhosis (2013)

The novel mutation p.G374S impairs transport function without disabling membrane localization of BSEP. While all other known BSEP mutations within transmembrane helices are associated with PFIC-2, the new p.G374S mutation causes a transitional phenotype between BRIC-2 and PFIC-2.
Optimization of Cis-Acting Elements for Gene Expression from Nonviral Vectors <i>In Vivo</i> (2003)

While naked DNA gene transfer in vivo usually results in transient gene expression, in some cases long-term transgene expression can be achieved. Here we demonstrate that cis-acting DNA elements flanking the transgene expression cassette and components in the plasmid backbone can significantly influence expression levels from nonviral vectors. To demonstrate this, we administered our most robust human coagulation factor IX (hFIX) expression cassette placed in two different plasmid backbones, into the livers of mice, by hydrodynamic transfection. We found that placing the expression cassette within a minimal plasmid vector pHM5, a modified version of pUC19, resulted in 10 times higher serum hFIX expression levels (up to 20,000 ng/ml, 400% of normal hFIX serum levels), compared to a pBluescript backbone. To optimally increase expression levels from a nonviral vector, we added matrix attachment regions (MARs) as cis-acting DNA elements flanking the hFIX expression cassette. We detected five fold higher hFIX expression levels in vivo for up to 1-year posttransfection from a vector that contained the chicken MAR from the lysozyme locus. Together, the present work demonstrates that in addition to the transgene expression cassette, cis-acting DNA elements within and outside of the plasmid backbone need to be evaluated to achieve optimal expression levels in a nonviral gene therapy approach.
Finite element analysis of three-phase induction motors: comparison of two different approaches (1999)

The paper presents a comparison between two different finite element analysis methods of three-phase induction motors. The first method is based on the equivalent circuit of the motor. The field solutions reproduce the indirect (no load and locked rotor) tests, to determine the parameters of the equivalent circuit. The second method, based only on the field solution, reproduces the direct (load) tests. It combines the field solution with the circuital one, imposing the motor voltage directly. Both approaches work with a two-dimensional discretised domain and are applied to a 4 poles and three-phase induction motor. The results are shown by means of figures and tables. From the comparison useful considerations about the finite element analysis of the induction motor can be obtained.
Neuroendocrine Control of Follicle-Stimulating Hormone (FSH) Secretion. I. Direct Evidence for Separate Episodic and Basal Components of FSH Secretion (1997)

Continuous sampling of hypophyseal portal blood from unrestrained sheep is providing an unprecedented means for measuring and defining the characteristics of the secretory profile of GnRH. With this method, GnRH has been shown to be released in discrete pulses lasting 5-8 min, with the amplitude of some pulses exceeding 50-fold. Although the relationship between these pulses and the accompanying pulses of LH measured in the jugular vein are unambiguous, the relationship of GnRH pulses to the release of FSH has not been well defined due to the longer clearance of FSH. In previous studies we have shown that hypophyseal portal blood, in addition to serving as a source material for hypothalamic secretions, provides a means to define secretory patterns of pituitary hormones. Because of this we hypothesized that the GnRH-FSH secretory relationships would be easier to define in hypophyseal portal than in jugular vein blood before the secretory products are subjected to dispersion and clearance in circulation. To test this possibility, we monitored hormonal patterns in blood collected at 5-min intervals for 6 -12 h from the
Dynamic rheology and foaming behaviour of styrene–ethylene–butylene–styrene/ polystyrene blends (2016)

Styrene–ethylene–butylene–styrene and its blends containing 10, 30 and 50 wt% polystyrene were subjected to batch foaming using physical blowing agent carbon dioxide. At higher foaming temperatures (80–110℃), complex viscosity ( η*) and storage modulus ( E′) were found to control the volume expansion ratio and the shrinkage of foams. For a given composition, optimal volume expansion was achieved at temperatures close to the glass transition temperature ( T g ) of the polystyrene phase of that composition, indicating the presence of a complex viscosity window favourable for the foaming process. Blends with 30% and 50% polystyrene content possessed higher values of E′ and η*, and produced stable foams having higher volume expansion ratio, when foamed within their respective η* windows. At a much lower foaming temperature (35℃), polystyrene was found to have a nucleating effect. However, irrespective of rheological properties, all foams showed prominent shrinkage. A higher polystyrene content resulted in a lower volume expansion ratio, as well as shrinkage over a shorter period of time and a greater extent of shrinkage in the same time span. This can be attributed to the selective foaming of the ethylene–butylene phase, hindered by the stiff polystyrene aggregates.
Assessment of Interlaboratory Variation in the Immunohistochemical Determination of Estrogen Receptor Status Using a Breast Cancer Tissue Microarray (2002)

The determination of tumor cell estrogen receptor (ER) expression status by immunohistochemical analysis has become standard practice, yet assay reproducibility has not been assessed adequately. By using a breast cancer tissue microarray, we examined interlaboratory variability in ER reporting. A 2-fold redundant tissue microarray block was created from 29 breast cancers. Unstained slides were distributed to 5 laboratories, and each laboratory immunostained and scored 1 slide for ER. Interlaboratory agreement ranged from moderate to high (overall kappa = 0.54 for 0-3+ grading; overall kappa = 0.84 for negative vs positive assessment of ER status). When 1 observer scored each of the 5 slides, interlaboratory agreement was slightly better (kappa = 0.63 for 0-3+ scoring; kappa = 0.96 for negative vs positive scoring). One laboratory, which had used an antibody and antigen retrieval method different from the others, demonstrated only fair concordance with the other 4 laboratories, but there was substantial intralaboratory interobserver agreement and excellent agreement with an outside observer reviewing the slide stained in that laboratory. The tissue microarray was an efficient and effective tool for identifying variability in ER reporting and should prove valuable in other external quality assurance programs.
Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management. (2000)

Attention Deficit/Hyperactivity Disorder (ADHD) is the most common behavioral disorder in children. ADHD is characterized by attention deficit, impulsivity, and sometimes overactivity ("hyperactivity"). The diagnosis is empirical, with no objective confirmation available to date from laboratory measures. ADHD begins in childhood and often persists into adulthood. The exact etiology is unknown; genetics plays a role, but major etiologic contributors also include adverse responses to food additives, intolerances to foods, sensitivities to environmental chemicals, molds, and fungi, and exposures to neurodevelopmental toxins such as heavy metals and organohalide pollutants. Thyroid hypofunction may be a common denominator linking toxic insults with ADHD symptomatologies. Abnormalities in the frontostriatal brain circuitry and possible hypofunctioning of dopaminergic pathways are apparent in ADHD, and are consistent with the benefits obtained in some instances by the use of methylphenidate (Ritalin) and other potent psychostimulants. Mounting controversy over the widespread use of methylphenidate and possible life-threatening effects from its long-term use make it imperative that alternative modalities be implemented for ADHD management. Nutrient deficiencies are common in ADHD; supplementation with minerals, the B vitamins (added in singly), omega-3 and omega-6 essential fatty acids, flavonoids, and the essential phospholipid phosphatidylserine (PS) can ameliorate ADHD symptoms. When individually managed with supplementation, dietary modification, detoxification, correction of intestinal dysbiosis, and other features of a wholistic/integrative program of management, the ADHD subject can lead a normal and productive life.
Surface conditioning solutions to reduce resist line roughness (2004)

In this study, surface conditioning solutions were used during post-develop process to enhance the 193 nm lithography performance. These solutions were applied to the wafer surface in a surface treatment step between the DI water rinse and drying steps. Compared to the standard develop process, the formulated surface conditioning solution enabled a 24% reduction in line width roughness, particularly in the high frequency roughness components. The solution also improved the pattern collapse performance by enlarging the non-collapse window and extending the minimum CD feature size by 10 nm. Additional benefits provided by the formulated surface conditioner solution were minimal changes to CD and resist profile.
Transcriptional Induction by Aromatic Amino Acids in <i>Saccharomyces cerevisiae</i> (1999)

Aromatic aminotransferase II, product of the ARO9 gene, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism in Saccharomyces cerevisiae. ARO9 expression is under the dual control of specific induction and nitrogen source regulation. We have here identified UASaro, a 36-bp upstream element necessary and sufficient to promote transcriptional induction of reporter gene expression in response to tryptophan, phenylalanine, or tyrosine. We then isolated mutants in which UASaro-mediated ARO9 transcription is partially or totally impaired. Mutations abolishing ARO9 induction affect a gene called ARO80 (YDR421w), coding for a Zn2Cys6 family transcription factor. A sequence highly similar to UASaro was found upstream from the YDR380w gene encoding a homolog of bacterial indolepyruvate decarboxylase. In yeast, this enzyme is postulated to catalyze the second step of tryptophan catabolism to tryptophol. We show that ARO9 and YDR380w (named ARO10) have similar patterns of transcriptional regulation and are both under the positive control of Aro80p. Nitrogen regulation of ARO9 expression seems not directly to involve the general factor Ure2p, Gln3p, Nil1p, Uga43p, or Gzf3p. ARO9 expression appears, rather, to be mainly regulated by inducer exclusion. Finally, we show that Gap1p, the general amino acid permease, and Wap1p (Ycl025p), a newly discovered inducible amino acid permease with broad specificity, are the main aromatic amino acid transporters for catabolic purposes.
Hydrocracking of Tetralin on Supported Nickel–Tungsten Catalysts (1977)

Abstract The hydrocracking of tetralin was carried out over supported nickel–tungsten (NiO 3%, WO3 20%) on silica–alumina, alumina, and silica catalysts at a hydrogen pressure of 100 atm and in the temperature range from 325 to 375 °C. The total conversion of tetralin and the product composition of hydrocracking were measured for the catalysts. The influence of pretreatment of the catalysts with H2 and H2S on the conversion and product composition was investigated for each catalyst. The hydrocracking of decalin was also carried out under the same conditions. It is found that the hydrocracking of tetralin proceeds along two reaction paths: (A) hydrogenation to decalin followed by conversion to methylperhydroindenes and C10-naphthenes, (B) isomerization to methylindans followed by cracking to butylbenzene. The selectivity of each reaction path and the catalytic properties are discussed.
Immunity to coccidiosis: effect of serum antibodies on cell invasion by sporozoites of<i>Eimeria in vitro</i> (1972)

A method for detecting antibody activity in vitro against the invasive stages of E. tenella and E. maxima is described. Treatment of cultured chick kidney monolayers with serum (or a globulin fraction thereof) from immunized birds caused a reduction in the numbers of intracellular stages 24 or 48 h after inoculation of sporozoites. This reduction was seen when serum was incorporated in the culture medium at the time of sporozoite inoculation and also, but to a lesser extent, when the monolayers had been pretreated with the antibody-containing medium which was washed off prior to infection. The results correlated reasonably well with those obtained when the sera were tested in embryo ( E. tenella ) or in vivo ( E. maxima ). Similar treatment of cultured CAM monolayers in which infection with E. tenella was well established (101 h), did not greatly affect the development of the parasite. This suggests that the anti-coccidial activity is either effective against the sporozoite stages only, or is unable to affect parasites within cells.
Indocyanine Green-Containing Nanostructure as Near Infrared Dual-Functional Targeting Probes for Optical Imaging and Photothermal Therapy (2011)

Indocyanine green (ICG) is a near-infrared (NIR) imaging agent and is also an ideal light absorber for laser-mediated photothermal therapy. This NIR dye could serve as a basis of a dual-functional probe with integrated optical imaging and photothermal therapy capabilities. However, applications of ICG remain limited by its concentration-dependent aggregation, poor aqueous stability, nonspecific binding to proteins and lack of target specificity. To overcome these limitations, a novel ICG-containing nanostructure is designed utilizing the noncovalent self-assembly chemistry between phospholipid-polyethylene glycol (PL-PEG) and ICG. The interactions between both amphiphilic ICG and PL-PEG were studied using absorption and fluorescence spectroscopy. The properties of ICG-PL-PEG nanoprobe, such as absorption and fluorescence spectra, stability, morphology and size distribution, were also investigated. Two representative targeting molecules, namely, a small molecule, folic acid (FA), and a large protein, integrin α(v)β₃ monoclonal antibody (mAb), were conjugated to the surface of ICG-PL-PEG nanoprobe, displaying the diversity of ligand conjugation. The target specificity was confirmed using three cell lines with different levels of available folate receptors (FRs) or integrin α(v)β₃ expression via laser scanning confocal microscope and flow cytometry. This targeting ICG-PL-PEG nanoprobe could be internalized into targeted cells via ligand-receptor mediated endocytosis pathway. Our in vitro experiments showed that internalized ICG-PL-PEG could be used for cell imaging and selective photothermal cell destruction. These results represent the first demonstration of the dual functionality of ICG-containing nanostructure for targeted optical imaging and photothermal therapy of cancerous cells. This novel ICG-PL-PEG nanostructure, when conjugated with other therapeutic and imaging agents, could become a multifunctional probe for cancer diagnosis and treatment.