gebhart/patrepeval huggingface dataset:
The role of septin 7 in physiology and pathological disease: A systematic review of current status (2018)

Septins are a conserved family of cytoskeletal GTPases present in different organisms, including yeast, drosophila, Caenorhabditis elegans and humans. In humans, septins are involved in various cellular processes, including exocytosis, apoptosis, leukemogenesis, carcinogenesis and neurodegeneration. Septin 7 is unique out of 13 human septins. Mammalian septin 6, septin 7, septin 2 and septin 9 coisolate together in complexes to form the core unit for the generation of the septin filaments. Physiological septin filaments are hetero-oligomeric complexes consisting of core septin hexamers and octamers. Furthermore, septin 7 plays a crucial role in cytokinesis and mitosis. Septin 7 is localized to the filopodia and branches of developing hippocampal neurons, and is the most abundant septin in the adult rat forebrain as well as a structural component of the human and mouse sperm annuli. Septin 7 is crucial to the spine morphogenesis and dendrite growth in neurons, and is also a structural constituent of the annulus in human and mouse sperm. It can suppress growth of some tumours such as glioma and papillary thyroid carcinoma. However, the molecular mechanisms of involvement of septin 7 in human disease, especially in the development of cancer, remain unclear. This review focuses on the structure, function and mechanism of septin 7 in vivo, and summarizes the role of septin 7 in cell proliferation, cytokinesis, nervous and reproductive systems, as well as the underlying molecular events linking septin 7 to various diseases, such as Alzheimer's disease, schizophrenia, neuropsychiatric systemic lupus erythematosus, tumour and so on.
The AVO modelling volume (2001)

An AVO modelling scheme is proposed in which we create a 3D volume of modelled CDP gathers by varying two physical parameters, one in the in-line direction, and one in the cross-line direction. This 3D volume is then processed using conventional AVO analysis techniques, and the results are interpreted using time or structure slices. Two examples are presented. The first involves P-wave velocity change in one direction versus S-wave velocity change in the other. In the second, we change porosity in one direction against water saturation in the other, using the Biot-Gassmann equations to perform the modelling. In the first example, an excellent fit is obtained between actual and expected results. In the second example, the fit is encouraging, but far from perfect. This study has therefore motivated future research into the use of multi-attribute statistical methods on this problem.
Influence of molecular weight and spinning conditions on the crystalline morphology of polypropylene fibres (1989)

Abstract In the spinning of polypropylene the “smectic” phase generally appears in the as spun fibres obtained from high fluidity polypropylene (for example M̄ w = 118000) at 200°C and more. The amount of the “smectic” form decreases as the draw down ratio increases. At 200°C and for a draw ratio of 40 the “smectic” form is about 70% of the crystalline phase. At 200°C and for a draw ratio of to 130 or higher, only the monoclinic form is observed. At 180°C, and whatever is the draw ratio, only the monoclinic form is observed. For high‐molecular ‐ weight polypropylene (for example M̄ w = 320000) the “smectic” form has never been observed whatever is the spinning temperature within the range 220–260°C. The fibres with high amount of smectic phase show low orientation factors, whereas the fibres having only monoclinic form show the highest orientation factors. These results, compared with elongational behaviour of the polypropylene, suggest that the smectic form appears in the fibres as the elongation rate on the spinning line is lower than the relaxation rate of polypropylene chains.
Design and Analysis of Low-Density Parity-Check Codes for Block-Fading Channels (2007)

We solve the problem of designing powerful low-density parity-check (LDPC) codes with iterative decoding for the block-fading channel. We present a new family of full-diversity LDPC codes that exhibit near outage limit performance. This family competes with multiplexed parallel turbo codes suitable for non-ergodic channels and recently reported in the literature.
Coronary Heart Disease (1970)

Right atrial pacing was performed in 41 subjects with coronary heart disease. Twenty developed angina pectoris during pacing, while 21 did not. The extent of coronary artery disease, as judged by selective cinearteriography, was similar in the two groups. Both had significant increases in heart rate and pressure-time per minute, but there was no significant difference in either of these parameters between groups. Among the hemodynamic parameters measured, the only statistically significant change was in the cardiac index which fell slightly but significantly in the angina group. There were no differences in myocardial oxygen extraction either within each group or between groups. In the angina group, however, 14 of 20 subjects exhibited abnormal myocardial lactate metabolism during pacing. The mean change was highly significant ( P < 0.01). In the nonangina group, eight of 21 subjects had abnormal lactate metabolism during pacing and the mean change was significant ( P < 0.05). There was no correlation between abnormal lactate metabolism and electrocardiographic evidence of myocardial ischemia in either group. Sublingual nitroglycerin, given to five subjects with angina while pacing was continued, resulted in prompt relief of symptoms, but abnormal lactate metabolism and ST-segment depression were unaffected after 10 min. By contrast, when anginal symptoms were relieved in five subjects by cessation of pacing, symptomatic improvement was accompanied by marked improvement in lactate metabolism after 10 min. Although angina pectoris appears to be related statistically to subnormal left ventricular function and abnormal lactate metabolism, there is significant individual variation.
Polymethoxyflavones Activate Ca<sup>2+</sup>-Dependent Apoptotic Targets in Adipocytes (2009)

Induction of apoptosis is an emerging strategy for the prevention and treatment of obesity because removal of adipocytes via apoptosis will result in reducing body fat and may help to maintain a long-lasting weight loss. Our previous studies have shown that a sustained increase in intracellular Ca(2+) triggers apoptosis in various cell types via activation of Ca(2+)-dependent proteases and that the apoptosis-inducing effect of polymethoxyflavones (PMFs) in cancer cells is mediated through Ca(2+) signaling. This paper reports that PMFs induce apoptosis in mature mouse 3T3-L1 adipocytes via activation of Ca(2+)-dependent calpain and Ca(2+)/calpain-dependent caspase-12. Treatment of adipocytes with PMFs evoked, in a concentration- and time-dependent fashion, sustained increase in the basal level of intracellular Ca(2+). The increase in Ca(2+) was associated with induction of apoptosis and activation of mu-calpain and caspase-12. Apoptosis-inducing activity of hydroxylated PMFs was significantly higher than that of the corresponding nonhydroxylated compounds. These results demonstrate that the apoptotic molecular targets activated by PMFs in adipocytes are Ca(2+)-dependent calpain and caspase-12. The findings obtained provide rationale for evaluating the role of PMFs in the prevention and treatment of obesity.
The Chemopreventive Effect of Mifepristone on Mammary Tumorigenesis Is Associated with an Anti-invasive and Anti-inflammatory Gene Signature (2012)

Progesterone receptor (PR) antagonists are potent antitumor agents in carcinogen and progestin-dependent mammary tumorigenesis models through both PR- and non-PR-mediated mechanisms. The PR antagonist mifepristone/RU486 has been used primarily as an abortifacient possessing high affinity for both the PR and glucocorticoid receptors (GR). To determine whether mifepristone would be effective as a chemopreventive agent, we assessed its effect on progestin/7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis in wild-type (WT) and estrogen receptor-α-positive (ER(+)) transgenic mice expressing the dominant-negative Pax8PPARγ (Pax8) fusion protein. Mifepristone administered at a dose of 2.5 mg significantly delayed mammary tumorigenesis in WT, but not in Pax8 mice, whereas, a three-fold higher dose almost completely blocked tumorigenesis in both WT and Pax8 mice. The sensitivity of WT mice to 2.5 mg mifepristone correlated with an expression profile of 79 genes in tumors, 52 of which exhibited the opposite response in Pax8 mice, and corresponded primarily to the downregulation of genes associated with metabolism, inflammation, and invasion. These results suggest that the chemopreventive activity of mifepristone in WT mice correlates with a specific gene expression signature that is associated with multiple nuclear receptor signaling pathways.
Overexpression of sarcolipin decreases myocyte contractility and calcium transient (2004)

We conclude that SLN may play an important role in regulating the SR calcium ATPase pump, possibly by interacting with phospholamban.
Evaluation of relationships between particle orientation and thermal conductivity in bark insulation board by means of CT and discrete modeling (2016)

Insulation boards made out of larch bark were pressed and scanned with an industrial X-ray computed tomograph (CT) in order to study the structure of the boards and to allow structure-based thermal modeling. The CT images were segmented using a categorization algorithm based on ANOVA. Apart from gaining knowledge about panel porosity, understanding of the inhomogeneous bark boards was enhanced by finding that two main components are prevalent. That knowledge of the board's inner microstructure enabled the application of a numerical model for thermal conductivity based on the finite difference method (FDM). Contrary to simple cut-ups, the application of CT and subsequent modeling enables the evaluation of the effects of particle orientation on a panel's thermal conductivity. Panels with horizontal particles (oriented parallel to the panel plane) proved to have a significantly lower thermal conductivity than panels with vertical particles (oriented orthogonal to the panel plane). This trend could be confirmed by means of the presented modeling approach, which allows further theoretical ex ante optimization in the production process. These findings give the direction for developments of efficient bark insulation panels with well-defined microstructure.
Bacillus azotofixans sp. nov., a Nitrogen-Fixing Species from Brazilian Soils and Grass Roots (1984)

A new species, Bacillus azotofixans, is described. This taxon is based upon 16 soil and root-associated strains that exhibit acetylene-reducing ability and nitrogen-fixing Bacillus sp. strain Hino. B. azotofixans is phenotypically similar to Bacillus polymyxa and Bacillus macerans. However, 13 tests (nitrate reduction; production of acid and gas from xylose, arabinose, lactose, ribose, and glycerol; resistance to lysozyme; liquefaction of gelatin; starch hydrolysis; decomposition of casein and pectin; production of dihydroxyacetone; susceptibility to B. polymyxa phages) differentiate it from B. polymyxa, and 12 characteristics (spore position; Voges-Proskauer test; nitrate reduction; production of acid and gas from xylose, arabinose, lactose, ribose, and glycerol; growth at 45°C; hydrolysis of starch; decomposition of pectin; formation of crystalline dextrins) differentiate it from B. macerans. The guanine-plus-cytosine contents of five strains ranged from 47.9 to 52.5 mol%. All strains reduced acetylene much more efficiently than B.polymyxa or B. macerans. In four strains, nitrogen fixation was confirmed by micro-Kjeldahl analysis of acetylene-reducing cultures. Acetylene reduction was not inhibited by nitrate and was not dependent on yeast extract or thiamin plus biotin. The proposed type strain of B. azotofixans is strain P3L-5 (= ATCC 35681).
Almost All Antipsychotics Result in Weight Gain: A Meta-Analysis (2014)

Given prolonged exposure, virtually all AP are associated with weight gain. The rational of switching AP to achieve weight reduction may be overrated. In AP-naive patients, weight gain is more pronounced.
Effect of Vehicles on Release of Meloxicam from Various Topical Formulations (2009)

This article evaluates the effect of various vehicles (O/W, W/O and two W/O/W emulsions and a hydrogel) on meloxicam release. One of W/O/W emulsions was named W/O/W-C containing Carbopol 934 as a gelling agent in its outer aqueous phase. Release of drug through cellulose acetate membrane was studied by using Franz-type diffusion cells. Hydrogel formulation gave the highest release with a significant difference followed by W/O/W, O/W, W/O/W-C and W/O emulsions. Increase in amount of oil phase resulted in slower drug release strictly indicating importance of lipophility of vehicle on release of lipophilic drugs like MX. Incorporation of MX in hydrogel increased the released amount by up to 20 times when compared with the other formulations. Increase in viscosity of the formulations was also followed the same order. Release study was performed by using UV spectroscopy. Furthermore, the determination method of MX was validated through the following performance criteria: linearity, intra-day and inter-day precision, accuracy, specifity and recovery. This method was proved as precise and accurate determination of MX in multi-component pharmaceutical preparations besides colorimetric methods.
Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. (1998)

Hepsin is a type II transmembrane serine protease highly expressed on the surface of hepatocytes. The physiological function of hepsin is not known, although in vitro studies indicate that hepsin plays a role in the initiation of blood coagulation and in hepatocyte growth. To determine the functional importance of hepsin, we generated hepsin-deficient mice by homologous recombination. Homozygous hepsin-/- mice were viable and fertile, and grew normally. In functional assays including tail bleeding time, plasma clotting times, and tissue factor- or LPS-induced disseminated intravascular coagulation models, no significant difference was found between hepsin-/- and wild-type litter mates. Liver weight and serum concentrations of liver-derived proteins or enzymes were similar in hepsin-/- and wild-type mice. Interestingly, serum concentrations of bone-derived alkaline phosphatase were approximately twofold higher in hepsin-/- mice of both sexes when compared with wild-type litter mates. No obvious abnormalities were found in major organs in hepsin-/- mice in histological examinations. Our results indicate that hepsin is not essential for embryonic development and normal hemostasis. Hepsin-/- mice will help to evaluate the long-term effects of hepsin deficiency in these animals.
Science and technology of ultra clean systems (2003)

The author argues that the semiconductor industry has grown as a result of borrowing a number of basic technologies from other fields. However, it is now time that the industry develop its own technologies for semiconductor manufacturing. In order to integrate a variety of technology fields, where terminologies are so different from one field to the other, into advanced semiconductor technology, a clearly stated leading principle is needed. Ultraclean technology as a leading principle is examined, and ultraclean processing technology is outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. (1994)

We have isolated complementary DNA clones encoding a novel orphan member of the nuclear receptor superfamily, termed BD73. This protein shows strong amino acid sequence similarity to the previously described Rev-ErbA alpha. Unlike Rev-Erb, in which the opposite strand of the C-terminal coding region encodes the C-terminal portion of a variant thyroid hormone receptor isoform, the opposite strand of the C-terminal coding region of BD73 does not have any extensive open reading frames. BD73 messenger RNA is expressed in a wide variety of tissues and cell lines. In quiescent HepG2 cells, BD73 messenger RNA levels are strongly induced by planar aromatic antioxidants. Like Rev-Erb, BD73 binds as a monomer to a DNA sequence which consists of a specific A/T-rich sequence upstream of the consensus hexameric half-site specified by the P box of the DNA-binding domain. Amino acid sequence comparisons suggest that the A box sequence, which has been suggested to mediate monomer binding by other superfamily members, lies closer to the DNA-binding domain in BD73 and Rev-Erb than in other receptors. Under the conditions examined, neither BD73 nor Rev-Erb activated reporters containing multiple copies of their common binding site. Thus, these two orphans may require an as yet unidentified ligand or other signal for such activation. Together, BD73 and Rev-Erb define a subgroup of orphan receptors that bind as monomers to a half-site flanked by a specific and extended A/T-rich sequence.
Acousto-optic Conversion of Laser Beams Into Flat-top Beams (1993)

Abstract We employ computer-optimized synthetic acousto-optic holograms to convert a laser beam (not necessarily Gaussian) into a nearly uniform-intensity partially coherent field in the Fourier plane. The width of the flat-top region can be controlled electronically in real time.
Cost‐effective facilities management: a practical approach (1996)

Investigates the cost effectiveness of facilities management in relation to the contribution which it makes to bottom‐line profits. Concludes that fully cost‐effective facilities can only be achieved where independent benchmarking exists and this leads to a facilities policy.
Design and evaluation of a versatile and efficient receiver-initiated link layer for low-power wireless (2010)

We present A-MAC, a receiver-initiated link layer for low-power wireless networks that supports several services under a unified architecture, and does so more efficiently and scalably than prior approaches. A-MAC's versatility stems from layering unicast, broadcast, wakeup, pollcast, and discovery above a single, flexible synchronization primitive. A-MAC's efficiency stems from optimizing this primitive and with it the most consequential decision that a low-power link makes: whether to stay awake or go to sleep after probing the channel. Today's receiver-initiated protocols require more time and energy to make this decision, and they exhibit worse judgment as well, leading to many false positives and negatives, and lower packet delivery ratios. A-MAC begins to make this decision quickly, and decides more conclusively and correctly in both the negative and affirmative. A-MAC's scalability comes from reserving one channel for the initial handshake and different channels for data transfer. Our results show that: (i) a unified implementation is possible; (ii) A-MAC's idle listening power increases by just 1.12x under interference, compared to 17.3x for LPL and 54.7x for RI-MAC; (iii) A-MAC offers high single-hop delivery ratios, even with multiple contending senders; (iv) network wakeup is faster and far more channel efficient than LPL; and (v) collection routing performance exceeds the state-of-the-art.
A Study of Anodization Process during Pore Formation in Nanoporous Alumina Templates (2006)

We have carried out a systematic investigation of the anodization procedure in order to determine the exact chemical mechanism of the dissolution process responsible for pore formation in nanoporous alumina templates. We measured the anodization current as a function of time and compared it with the thickness of porous aluminum oxide layer obtained from cross-section scanning electron microscopy images. From this, we calculated the number of moles of electrons generated per mole of porous alumina grown. This analysis is consistent with a reaction mechanism in which aluminum is converted to aluminum oxide in addition with the direct transfer of aluminum ions across the thin barrier aluminum oxide into the electrolyte. Hence, experimental evidence is reported that indicate that the dissolution process observed is that ofAl<sup>3</sup><sup>+</sup> ions migrating across the barrier layer and dissolving into the solution. Contrary to the suggestion of some authors, these experiments indicate that at most a negligible amount of oxide dissolves during the anodization of aluminum.
Minimizing reference count updating with deferred and anchored pointers for functional data structures (1994)

article Free Access Share on Minimizing reference count updating with deferred and anchored pointers for functional data structures Author: Henry G. Baker Nimble Computer Corporation, 16231 Meadow Ridge Way, Encino, CA Nimble Computer Corporation, 16231 Meadow Ridge Way, Encino, CAView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 29Issue 9Sept. 1994 pp 38–43https://doi.org/10.1145/185009.185016Published:01 September 1994Publication History 28citation94DownloadsMetricsTotal Citations28Total Downloads94Last 12 Months42Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Monitoring of Milk Quality With Disposable Taste Sensor (2003)

A disposable screen-printed multi channel taste sensor composed of several types of lipid as transducers and a computer as data analyzer could detect taste in a manner similar to human gustatory sensation. The disposable taste sensor was used to measure the electrical potential resulted from the interaction between lipid membranes and taste substances. In the present study, two types of packaged commercial milk, the ultra high temperature (UHT) and the pasteurized milk were tested. It was found that the disposable taste sensor is capable to discriminate reliably between fresh and spoiled milk and to follow the deterioration of the milk quality when it is stored at room temperature based on a pattern recognition principle namely Principle Component Analysis (PCA). This research could provide a new monitoring method ideally for simple and cheap decentralized testing for controlling the quality of milk, which may be of great use in the dairy industries.
The <i>ars</i> Operon in the <i>skin</i> Element of <i>Bacillus subtilis</i> Confers Resistance to Arsenate and Arsenite (1998)

The Bacillus subtilis skin element confers resistance to arsenate and arsenite. The ars operon in the skin element contains four genes in the order arsR, ORF2, arsB, and arsC. Three of these genes are homologous to the arsR, arsB, and arsC genes from the staphylococcal plasmid pI258, while no homologs of ORF2 have been found. Inactivation of arsR, arsB, or arsC results in either constitutive expression of ars, an arsenite- and arsenate-sensitive phenotype, or an arsenate-sensitive phenotype, respectively. These results suggest that ArsR, ArsB, and ArsC function as a negative regulator, a membrane-associated protein need for extrusion of arsenite, and arsenate reductase, respectively. Expression of the ars operon was induced by arsenate, arsenite, and antimonite. Northern hybridization and primer extension analysis showed that synthesis of a full-length ars transcript of about 2.4 kb was induced by arsenate and that the ars promoter contains sequences that resemble the -10 and -35 regions of promoters that are recognized by E sigmaA.