gebhart/patrepeval huggingface dataset:
Simple reception techniques for coordinated two-pair digital transmission (2002)

Simple coordinated transmission schemes are proposed and analyzed, in which independent but identically PAM (pulse-amplitude-modulation) coded data are transmitted over two subscriber loop pairs in the presence of near-end crosstalk from other pairs' transmitters. A maximum-likelihood detection scheme utilizing noise variance and correlation between the two pairs is shown to yield significant improvement in performance, especially if there is an unbalance in the channel signal-to-noise ratios on the two pairs, or if there is significant noise correlation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Calculation of Pressure Gradients from MR Velocity Data in a Laminar Flow Model (1991)

The MR velocity data obtained in a simple geometry and low Reynolds number are employed to calculate pressure gradients using the known solution of the Navier-Stokes equation. Calculations compare favorably with measured results for the simple model presented. The potential usefulness of noninvasive pressure gradient determination from quantitative analysis of imaging-derived velocity distributions is suggested.
REDUCTION OF MORBIDITY AND CYTOKINE RELEASE IN ANTI-CD3 MoAb-TREATED MICE BY CORTICOSTEROIDS (1990)

In keeping with the in vitro mitogenic properties of anti-CD3 MoAbs, the first injections of anti-CD3 are invariably responsible for an in vivo cellular activation. This activation induces a massive cytokine release in the circulation (TNF, IFN gamma, IL-2, IL-6, and IL-3). Paralleling this release, a severe clinical reaction occurs in OKT3-treated patients and in 145 2C11-treated mice. Corticosteroids both in vitro and in vivo inhibit the production of several cytokines involved in the anti-CD3 reaction. A single 1 mg hydrocortisone dose was administered to 145 2C11-treated mice according to different kinetics schedules. When given 1 hr prior to the anti-CD3 MoAb, hydrocortisone exerted a beneficial effect on the mouse physical reaction. Hypothermia was totally abrogated at the 4-hr time point. Diarrhea decreased by 50%. Hypomotility improved although not significantly. This improvement correlated with a major modification in the anti-CD3 pattern of cytokine release. At the 90-min blood withdrawal time point cytokine serum levels showed a 100% decrease for IFN gamma, an 88% decrease for IL-6, and 85% decrease for IL-2, and a 75% decrease for TNF. At 4 hr IL-2 serum levels were diminished by 65%; IL-6, IL-3, and IFN gamma serum levels were comparable to controls; and, interestingly, TNF was still detected, whereas it has already disappeared when 145 2C11 was administered alone. Importantly, when given more than 1 hr prior to anti-CD3 injection, corticosteroids were ineffective. To conclude, high doses of corticosteroids must be given with a precise kinetics--i.e. 1 hr prior to anti-CD3 MoAb--to achieve their maximal beneficial effect in the prevention of the anti-CD3 reaction.
A fault-tolerant protocol for providing the exactly-once property of mobile agents (2002)

Mobile agent technology has been proposed for various fault-sensitive application areas, including electronic commerce, systems management and active messaging. Due to the autonomy of mobile agents, there is no natural instance that monitors the progress of an agent's execution. As a result, agents may be lost or blocked due to node crashes or network partitioning even if there are other nodes available that could continue processing. In this paper, we describe a protocol that provides exactly-once semantics of agent execution and additionally reduces the blocking probability of agents by introducing observer nodes for monitoring the progress of agents. This protocol is based on conventional transactional technology such as defined by X/Open DTP or CORBA OTS. It is being implemented in Mole, a mobile agent system developed at Stuttgart University.
Shale Stability: Drilling Fluid Interaction and Shale Strength (1999)

Abstract This paper presents main results of a shale stability study, related to the understanding of shale/fluid interaction mechanisms, and discusses shale strength correlation. The major shale/fluid interaction mechanisms: Capillary, osmosis, hydraulic, swelling and pressure diffusion, and recent experimental results are discussed. Factors affecting the shale strength are discussed, and a sonic compressional velocity-log based correlation for strength is proposed. Recommendations for modeling and improving shale stability are described, based on the current understanding of shale stability.
Effects of low molecular chitosan on pH changes in human dental plaque. (1994)

Effects of six kinds of low molecular chitosan (LMCS) on pH changes in dental plaque were compared in vitro and in vivo in order to clarify the relationship between their characteristics and effectiveness. Six LMCS with different molecular weights (MW) (500-3,000) and degrees of deacetylation (DAC) (50-95%) were prepared for this study. Evaluations using S. mutans cell suspensions in vitro showed that all samples had almost equal abilities to reduce pH fall in dental plaque. They were found to have no influence on the glycolytic activity of S. mutans. However, clinical evaluations of pH fall in dental plaque using an ion-sensitive field-effect transistor (ISFET) electrode showed unexpected results as follows; The most reduction in pH fall was obtained with the LMCS with a MW of 3,000 and a DAC of 50%, which had been presumed to be the most ineffective sample. The second ranked LMCS in this experiment had a MW of 500 and a DAC of 95%; it had been expected to be the most effective one. The findings indicated that LMCS has a high ability to inhibit pH fall in dental plaque and suggested that such properties as molecular weight and degree of deacetylation can have great influences upon its activity in clinical application.
Phosphorylation of Caveolin by Src Tyrosine Kinases (1996)

Caveolae are flask-shaped plasma membrane specializations that are thought to exist in most cell types. A 22-kDa protein, caveolin, is an integral membrane component of caveolae membranes in vivo. Previous studies have demonstrated that caveolin is phosphorylated on tyrosine by oncogenic viral Src (v-Src) and that caveolin is physically associated as a hetero-oligomeric complex with normal cellular Src (c-Src) and other Src family tyrosine kinases. Caveolin contains eight conserved tyrosine residues that may serve as potential substrates for Src. Here, we have begun to study the phosphorylation of caveolin by Src family tyrosine kinases both in vitro and in vivo. Using purified recombinant components, we first reconstituted the phosphorylation of caveolin by Src kinase in vitro. Microsequencing of Src-phosphorylated caveolin revealed that phosphorylation occurs within the extreme N-terminal region of full-length caveolin between residues 6 and 26. This region contains three tyrosine residues at positions 6, 14, and 25. Deletion mutagenesis demonstrates that caveolin residues 1-21 are sufficient to support this phosphorylation event, implicating tyrosine 6 and/or 14. In vitro phosphorylation of caveolin-derived synthetic peptides and site-directed mutagenesis directly show that tyrosine 14 is the principal substrate for Src kinase. In support of these observations, tyrosine 14 is the only tyrosine residue within caveolin that bears any resemblance to the known recognition motifs for Src family tyrosine kinases. In order to confirm or refute the relevance of these in vitro studies, we next analyzed the tyrosine phosphorylation of endogenous caveolin in v-Src transformed NIH 3T3 cells. In vivo, two isoforms of caveolin are known to exist: alpha-caveolin contains residues 1-178 and beta-caveolin contains residues 32-178. Only alpha-caveolin underwent tyrosine phosphorylation in v-Src transformed NIH 3T3 cells, although beta-caveolin is well expressed in these cells. As beta-caveolin lacks residues 1-31 (and therefore tyrosine 14), these in vivo studies directly demonstrate the validity of our in vitro studies. Because alpha- and beta-caveolin are known to assume a distinct but overlapping subcellular distribution within a single cell, v-Src phosphorylation of alpha-caveolin may only affect a subpopulation of caveolae that contain alpha-caveolin.
LEVELS OF P53 ANTIGEN IN THE SERUM OF NONSMALL CELL LUNG-CANCER PATIENTS CORRELATE WITH POSITIVE P53 IMMUNOHISTOCHEMISTRY ON TUMOR SECTIONS, TUMOR NECROSIS AND NODAL INVOLVEMENT (1994)

We examined 50 non-small cell lung cancers and the matching serum from the same patients for the levels of p53 antigen. Histological sections of the tumor specimens were stained with anti-p53 specific antibodies, and the sera were tested by ELISA. We observed a correlation between the expression of the p53 protein in the tumors and the presence of circulating p53 antigen, using either a wild type-(P=0.024) or a mutant specific (P=0.007) ELISA test. The p53 serum levels were also significantly associated (P=0.019) with the extent of tumor necrosis, suggesting that circulating p53 may be derived by shedding from dead tumor cells. The levels of mutant p53 detected in the serum were significantly higher in patients with lymph node involvement (P=0.012) and with late-staged disease. (P=0.05). No association was found with tumor size and extent. Testing for serum levels of mutant p53 could provide additional prognostic information and could be used as as novel molecular diagnostic tool in the management of non-small cell lung cancer.
Robotic ultrasound‐guided prostate intervention device: system description and results from phantom studies (2009)

Our device demonstrates safety in a defined boundary with a repeatable accuracy of < 1 mm. It can be used for accurate prostate biopsy and treatment delivery.
Nanowires Enabling Signal‐Enhanced Nanoscale Raman Spectroscopy (2008)

Silicon nanowires grown by the vapor-liquid-solid (VLS) mechanism catalyzed by gold show gold caps (droplets) approximately 20-500 nm in diameter with a half spherical towards almost spherical shape. These gold droplets are well suited to exploit the surface-enhanced Raman scattering (SERS) effect and could be used for tip-enhanced Raman spectroscopy (TERS). The gold droplet of a nanowire attached to an atomic force microscopy (AFM) tip could locally enhance the Raman signal and increase the spatial resolution. Used as a SERS template, an ensemble of self-organizing nanowires grown bottom up on a silicon substrate could allow highly sensitive signal-enhanced Raman spectroscopy of materials that show a characteristic Raman signature. A combination of a nanowire-based TERS probe and a nanowire-based SERS substrate promises optimized signal enhancement so that the detection of highly dilute species, even single molecules or single bacteria or DNA strands, and other soft matter is within reach. Potential applications of this novel nanowire-based SERS and TERS solution lie in the fields of biomedical and life sciences, as well as security and solid-state research such as silicon technology.
Histone Deacetylase Inhibitors Suppress the Inducibility of Nuclear Factor-κB by Tumor Necrosis Factor-α Receptor-1 Down-regulation (2006)

Recently, the inhibition of histone deacetylase (HDAC) enzymes has attracted attention in the oncologic community as a new therapeutic opportunity for hematologic and solid tumors including non-small cell lung cancer (NSCLC). In hematologic malignancies, such as diffuse large B-cell lymphoma, the HDAC inhibitor (HDI), suberoylanilide hydroxamic acid (SAHA), has recently entered phase II and III clinical trials. To further advance our understanding of their action on tumor cells, we investigated the possible effect of HDI treatment on the functionality of the nuclear factor-kappaB (NF-kappaB) pathway in NSCLC. We found that in the NSCLC cell lines, A549 and NCI-H460, the NF-kappaB pathway was strongly inducible, for example, by stimulation with tumor necrosis factor-alpha (TNF-alpha). Incubation of several NSCLC cell lines with HDIs resulted in greatly reduced gene expression of TNF-alpha receptor-1. HDI-treated A549 and NCI-H460 cells down-regulated TNF-alpha receptor-1 mRNA and protein levels as well as surface exposure, and consequently responded to TNF-alpha treatment with reduced IKK phosphorylation and activation, delayed IkappaB-alpha phosphorylation, and attenuated NF-kappaB nuclear translocation and DNA binding. Accordingly, stimulation of NF-kappaB target gene expression by TNF-alpha was strongly decreased. In addition, we observed that SAHA displayed antitumor efficacy in vivo against A549 xenografts grown on nude mice. HDIs, therefore, might beneficially contribute to tumor treatment, possibly by reducing the responsiveness of tumor cells to the TNF-alpha-mediated activation of the NF-kappaB pathway. These findings also hint at a possible use of HDIs in inflammatory diseases, which are associated with the overproduction of TNF-alpha, such as rheumatoid arthritis or Crohn's disease.
Is hypoglycaemia associated with cognitive impairment in type 2 diabetes? : original article (2015)

It is well recognised that both type 1 and type 2 diabetes may be associated with cognitive dysfunction and that the incidence of dementia is higher in people with diabetes than among those without. 
In a general population, cognitive impairment exists along a spectrum, ranging from mild deficits that may not be clinically detectable, to the severe disability associated with dementia. The most common forms of dementia are late onset Alzheimer's disease (LOAD), accounting for 70 to 90 % of all cases, vascular dementia and mixed dementia. Mixed dementia bears clinical features of both the LAOD and vascular forms. Alzheimer's disease, although primarily considered a neurodegenerative condition, frequently occurs with concurrent cerebrovascular lesions, which may play a role in the clinical evolution of the illness.
Heavy Meromyosin: Evidence for a Refractory State Unable to Bind to Actin in the Presence of ATP (1972)

The binding of actin to heavy meromyosin (HMM) in the presence of ATP was studied by analytical ultracentrifuge and ATPase studies. At 0 degrees C, at very low ionic strength, the double-reciprocal plot of HMM ATPase against actin concentration is linear. If one assumes that all of the HMM is bound to actin when the ATPase activity equals V(max), then, at an actin concentration where the actin-HMM ATPase is 85% of V(max), all but 15% of the HMM should be complexed with actin. However, when the binding of HMM to actin in the presence of ATP was measured with the analytical ultracentrifuge, more than 60% of the HMM was not bound to actin. From experiments with EDTA- and Ca-ATPases it seemed unlikely that the unbound HMM was denatured. It is thus possible that during the steady-state hydrolysis of ATP, HMM spends more than 50% of its cycle of interaction with actin and ATP in a "refractory state," unable to bind to actin, i.e., while an HMM molecule goes through one cycle of interaction with actin and ATP, an actin monomer could bind and release several HMM molecules so that the turnover rate per mole of added actin would be considerably greater than that per mole of added HMM. Comparison of the rate of ATPase activity at very high actin concentration with that at very high HMM concentration shows that this is indeed so. Therefore, both kinetic and ultracentrifuge studies suggest that the HMM exists in a refractory state during a large part of its cycle of interaction with actin and ATP.
Extension of a DNA Molecule by Local Heating with a Laser (2007)

Thermal convection and thermophoresis induced by mum-scale local heating are shown to elongate a single DNA molecule. An infrared laser used as a point heat source is converged into a dispersion solution of DNA molecules, which is observed under a fluorescent microscope. The thermal convection around the laser focus manifests as extensional flow for the long DNA chain. A simulation of thermal convection that reproduces the experimental condition provides numerical support for the stretching caused by thermal convection. This DNA elongation technique is a novel method for manipulating the intact single DNA molecules, and it can be applied to a "lab on a chip".
Some new quinoline-based mono and dicarboxylic acids. (1993)

Some quinoline-based mono- and dicarboxylic acids structurally related to kynurenic acid have been synthesized and screened as antagonists of neurotransmission of NMDA, AMPA and KA excitatory amino acid receptors. Higher affinity for NMDA receptor was pointed out in the short series, but all the compounds, even those with key structural features of glutamic acid showed no significant activity.
The Communication Process (1967)

(1967). The Communication Process. Journal of the Institute of Health Education: Vol. 5, No. 3, pp. 2-7.
Multiple myeloma–related deregulation of bone marrow–derived CD34+ hematopoietic stem and progenitor cells (2012)

Multiple myeloma (MM) is a clonal plasma cell disorder frequently accompanied by hematopoietic impairment. We show that hematopoietic stem and progenitor cells (HSPCs), in particular megakaryocyte-erythrocyte progenitors, are diminished in the BM of MM patients. Genomic profiling of HSPC subsets revealed deregulations of signaling cascades, most notably TGFβ signaling, and pathways involved in cytoskeletal organization, migration, adhesion, and cell-cycle regulation in the patients. Functionally, proliferation, colony formation, and long-term self-renewal were impaired as a consequence of activated TGFβ signaling. In accordance, TGFβ levels in the BM extracellular fluid were elevated and mesenchymal stromal cells (MSCs) had a reduced capacity to support long-term hematopoiesis of HSPCs that completely recovered on blockade of TGFβ signaling. Furthermore, we found defective actin assembly and down-regulation of the adhesion receptor CD44 in MM HSPCs functionally reflected by impaired migration and adhesion. Still, transplantation into myeloma-free NOG mice revealed even enhanced engraftment and normal differentiation capacities of MM HSPCs, which underlines that functional impairment of HSPCs depends on MM-related microenvironmental cues and is reversible. Taken together, these data implicate that hematopoietic suppression in MM emerges from the HSPCs as a result of MM-related microenvironmental alterations.
Beneficial Role of Pancreatic Microenvironment for Angiogenesis in Transplanted Pancreatic Islets (2009)

Pancreatic islets implanted heterotopically (i.e., into the kidney, spleen, or liver) become poorly revascularized following transplantation. We hypothesized that islets implanted into the pancreas would become better revascularized. Islets isolated from transgenic mice expressing enhanced yellow fluorescent protein (EYFP) in all somatic cells were cultured before they were implanted into the pancreas or beneath the renal capsule of athymic mice. Vascular density was evaluated in histological sections 1 month posttransplantation. EYFP was used as reporter for the transgene to identify the transplanted islets. Islet endothelial cells were visualized by staining with the lectin Bandeiraea simplicifolia (BS-1). Capillary numbers in intrapancreatically implanted islets were only slightly lower than those counted in endogenous islets, whereas islets implanted beneath the renal capsule had a markedly lower vascular density. In order to determine if this high graft vascular density at the intrapancreatic site reflected expansion of remnant donor endothelial cells or increased ingrowth of blood vessels from the host, also islets from Tie2-green fluorescent protein (GFP) mice (i.e., islets with fluorescent endothelial cells) were transplanted into the pancreas or beneath the renal capsule of athymic mice. These islet grafts revealed that the new vascular structures formed in the islet grafts contained very few GFP-positive cells, and thus mainly were of recipient origin. The reason(s) for the much better ingrowth of blood vessels at the intrapancreatic site merits further studies, because this may help us form strategies to overcome the barrier for ingrowth of host vessels also into islets in heterotopic implantation sites.
A comparative study of the structure of evaporated and glow discharge silicon (1977)

The structure of evaporated amorphous silicon and amorphous silicon prepared by glow discharge technique is investigated using phase contrast electron microscopy and electron diffraction. While evaporated Si shows a supernetwork of density fluctuations commonly observed in evaporated amorphous tetrahedrally bonded semiconductors, glow discharge Si shows no such quasiperiodic heterogeneous density fluctuation. Electron diffraction patterns are obtained using a translation detector, which directly measures the electron intensity in the image plane of the electron microscope. From the resulting RDF it is concluded, that there is a higher degree of local order in glow discharge Si. Mit Hilfe von Phasenkontrast-Elektronenmikroskopie und Elektronenbeugung wird die Struktur von aufgedampftem amorphem Silizium und von amorphem Silizium, das mit der “glow discharge” -Technik gewonnen wurde, untersucht. Während aufgedampftes Si das Supernetzwerk von Dichtefluktuationen zeigt, wie es üblicherweise in aufgedampften tetraedrisch gebundenen amorphen Halbleitern gefunden wird, hat “glow discharge”-Si keine solche heterogene, quasiperiodische Dichtefluktuation. Mit Hilfe eines Translationsdetektors, der die Elektronenintensität direkt in der Bildebene des Elektronenmikroskops mißt, wird das Elektronenbeugungsspektrum aufgenommen. Aus der resultierenden RDF wird geschlossen, daß der Grad der lokalen Ordnung in “glow discharge”-Si größer ist.
An ANN's evolved by a new evolutionary system and its application (2002)

The paper presents a new evolutionary system for evolving artificial neural networks (ANN). In the process of evolution, the network architecture and the node weights of ANN are evolved alternately, and the evolution value of network architecture is related to the error value of ANN evolved by node weights. An evolved ANN has been used in modelling product quality estimator for a fractionator of the hydrocracking unit in the oil refining industry. The results show that it has good accuracy and generalisation ability.
Homoepitaxy of GaN on polished bulk single crystals by metalorganic chemical vapor deposition (1996)

Bulk single crystals of GaN were used for epitaxial growth of GaN by metalorganic chemical vapor deposition. Photoluminescence (at 2 K) from polished substrates yields a broad near-band-edge emission band centered at 3.32 eV and the commonly observed yellow luminescence band. In contrast, the epitaxial layer displays a strong, sharp bound exciton line at 3.458 eV and a weak yellow band. Transmission electron microscopy reveals a sharp, planar interface between substrate and epilayer: The substrate contains small Ga inclusions, and the epilayer consists of less than 108 dislocations per cm2, mostly in the form of dislocation loops, which originate at the interface.