gebhart/patrepeval huggingface dataset:
Let‐7a elevates p21<sup>WAF1</sup> levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells (2009)

Down-regulation of let-7 microRNA (miRNA) is a key event in lung cancer. Despite recent advances in survival signaling, the roles of let-7 in the context of lung cancer are not fully clear. In this study, we showed that let-7a, a member of let-7 family, negatively regulated the expression of NIRF through NIRF 3' UTR. We also showed that NIRF was required for the let-7a-mediated elevation of p21(WAF1). These findings suggest that growth-inhibitory effect of let-7a on the A549 cells in vitro and in vivo may be explained in part by le-7a-induced suppression of NIRF and elevation of p21(WAF1). This work reveals a novel regulatory mechanism for let-7a in the control of cellular proliferation and lung carcinogenesis.
Phenomenological separation in a three-phase hydrocyclone. (1997)

Recent developments in liquid-liquid and solid-liquid separation reveal that the conventional two-phase hydrocyclone is an indispensable tool in petroleum and allied industries. This is attributable to its simplicity of operation and numerous diverse applications. In spite of the many advantages it offers, the hydrocyclone suffers a major drawback in the separation of multiple-phase immiscible mixtures. Occurrence of these mixtures, as dispersions of oil and solids within liquids, can be epidemic and environmentally undesirable. In resolving this impediment, the author developed a three-phase liquid-solid-liquid separation hydrocyclone by hydrodynamically incorporating a transverse aperture into a two-phase design.
Improving the Modulation Bandwidth in Semiconductor Lasers by Passive Feedback (2007)

We explore the concept of passive-feedback lasers (PFLs) for direct signal modulation at 40 Gb/s. Based on numerical simulation and bifurcation analysis, we explain the main mechanisms in these devices that are crucial for modulation at high speed. The predicted effects are demonstrated experimentally by means of correspondingly designed devices. In particular, a significant improvement of the modulation bandwidth at low-injection currents can be demonstrated
Stored Value Cards: Challenges and Opportunities for Reaching Emerging Markets* (2005)

This paper presents preliminary findings and is being distributed to interested readers solely to stimulate discussion and to elicit comments. The views expressed in the paper are those of the authors and are not necessarily reflective of views at the Federal Reserve Bank of New York or
Schizophrenia and the myth of intellectual decline (1997)

The deficit in intellectual function observed in these patients, and reported in the literature, is lifelong and predates the onset of schizophrenia.
Discrimination of Gastrointestinal Nematode Eggs from Crude Fecal Egg Preparations by Inhibitor-Resistant Conventional and Real-Time PCR (2013)

<div><p>Diagnosis of gastrointestinal nematodes relies predominantly on coproscopic methods such as flotation, Kato-Katz, McMaster or FLOTAC. Although FLOTAC allows accurate quantification, many nematode eggs can only be differentiated to genus or family level. Several molecular diagnostic tools discriminating closely related species suffer from high costs for DNA isolation from feces and limited sensitivity since most kits use only small amounts of feces (<1 g). A direct PCR from crude egg preparations was designed for full compatibility with FLOTAC to accurately quantify eggs per gram feces (epg) and determine species composition. Eggs were recovered from the flotation solution and concentrated by sieving. Lysis was achieved by repeated boiling and freezing cycles – only <i>Trichuris</i> eggs required additional mechanic disruption. Egg lysates were directly used as template for PCR with Phusion DNA polymerase which is particularly resistant to PCR inhibitors. Qualitative results were obtained with feces of goats, cattle, horses, swine, cats, dogs and mice. The finally established protocol was also compatible with quantitative real-time PCR in the presence of EvaGreen and no PCR inhibition was detectable when extracts were diluted at least fourfold. Sensitivity was comparable to DNA isolation protocols and spiked samples with five epg were reliably detected. For <i>Toxocara cati</i> a detection limit below one epg was demonstrated. It was possible to distinguish <i>T. cati</i> and <i>Toxocara canis</i> using high resolution melt (HRM) analysis, a rapid tool for species identification. In human samples, restriction fragment length polymorphism (RFLP) and HRM analysis were used to discriminate <i>Necator americanus</i> and <i>Ancylostoma duodenale</i>. The method is able to significantly improve molecular diagnosis of gastrointestinal nematodes by increasing speed and sensitivity while decreasing overall costs. For identification of species or resistance alleles, analysis of PCR products with many different post PCR methods can be used such as RFLP, reverse-line-blot, Sanger sequencing and HRM.</p> </div>
Protein tyrosine phosphorylation in synaptic vesicles. (1988)

Protein tyrosine phosphorylation in purified synaptic vesicles from rat forebrain has been studied in the presence of Mn2+ and orthovanadate. High levels of endogenous protein tyrosine phosphorylation were observed. Four major phosphoproteins, with apparent molecular masses of 105, 94, 38, and 30 kDa, were shown to contain phosphotyrosine. The 38-kDa phosphoprotein was identified as synaptophysin (p38), a well-characterized integral membrane protein of synaptic vesicles. The three other phosphotyrosine-containing proteins distributed in the same manner as synaptophysin in all subcellular fractions. Like synaptophysin, the two high molecular weight phosphotyrosine proteins (105 and 94 kDa) were found to be glycoproteins by lectin chromatography. Tyrosine phosphorylation of synaptophysin was an intravesicular reaction and reached 50% of maximal level within 3 min. Triton X-100, a nonionic detergent, inhibited tyrosine phosphorylation of endogenous protein substrates but not the phosphorylation of an exogenous substrate, poly(Glu80,-Tyr20). Tyrosine phosphorylation of synaptophysin was also demonstrated in synaptosomes, indicating that tyrosine phosphorylation of synaptic vesicle proteins occurs in intact nerve terminals.
Dose‐Escalation Study of ICA‐17043 in Patients with Sickle Cell Disease (2006)

Total systemic exposure of ICA-17043 after a single oral dose, as measured by AUC(0-infinity), increased nearly proportionally with the dose. The rate of absorption, however, appeared to be delayed at doses greater than 100 mg. With the long half-life of ICA-17043 demonstrated in this study, once-daily dosing is probably adequate to maintain steady-state plasma concentrations. In addition, single doses of ICA-17043 were well tolerated.
Passive‐matrix‐driven field‐sequential‐color displays (2008)

Abstract— Passive‐matrix‐driven field‐sequential‐color (FSC) displays were successfully fabricated. It makes use of a new multiplex driving scheme that does not depend on voltage averaging. Instead, a transient response of the liquid crystal is employed. An addressing and response time of less than 70 μsec and 2.0 msec, respectively, are used. Scanning time compensation is also introduced to improve the brightness uniformity of the display.
Physiological and biochemical studies on psychrotolerance in Listeria monocytogenes (1997)

Studies were undertaken to explain the ability of Listeria monocytogenes to grow at low temperatures in a chemostat. It was found that when grown in continuous culture at a dilution rate of 0.02 h-1 L. monocytogenes had a lower proportion of anteiso-17:0, and a higher proportion of anteiso-15:0, and smaller chain fatty acids when grown at 10 degrees C compared to 30 degrees C. A previously unreported glycolipid was only seen after growth at low temperature. Growth temperature had no effect on the rate of glucose uptake.
Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of<i>Clostridium perfringens</i>alpha-toxin and a non-toxic NetB variant (2016)

Necrotic enteritis toxin B (NetB) is a pore-forming toxin produced by Clostridium perfringens and has been shown to play a key role in avian necrotic enteritis, a disease causing significant costs to the poultry production industry worldwide. The aim of this work was to determine whether immunization with a non-toxic variant of NetB (NetB W262A) and the C-terminal fragment of C. perfringens alpha-toxin (CPA247-370) would provide protection against experimental necrotic enteritis. Immunized birds with either antigen or a combination of antigens developed serum antibody levels against NetB and CPA. When CPA247-370 and NetB W262A were used in combination as immunogens, an increased protection was observed after oral challenge by individual dosing, but not after in-feed-challenge.
Surface plasmon microscopic characterization of external surfaces (1989)

Surface plasmon microscopy (SPM) is used, for the first time, to image external samples with a surface relief structure. This is demonstrated in an experimental coupling setup which combines elements of both the Otto and the Kretschmann configuration. The contrast is shown to be generated between areas of different surface plasmon excitation efficiencies. It is shown that periodic surface structures also can be read-out in Fourier-space by surface plasmon diffraction. Finally, Fresnel calculations are presented that demonstrate the contrast improvement achievable by immersion SPM using a suitable liquid.
Magnetics in Doppler signal data extraction (1961)

The purpose of this paper is to describe a solid-state approach to the Doppler radar data extraction problem using nonlinear magnetic techniques. The mechanization details will therefore be preceded by sufficient radar system background pertinent to this application.
Delaying Transmissions in Data Communication Networks to Improve Transport-Layer Performance (2011)

Packet losses in the network have a considerable performance impact on transport-layer throughput. For reliable data transfer, lost packets require retransmissions and thus cause very long delays. This tail of the packet delay distribution causes performance problems. There are several approaches to trading off networking resources up-front to reduce long delays for some packets (e.g., forward error correction, network coding). We propose packet pacing as an alternative that changes traffic characteristics favorably by adding intentional delay in packet transmissions. This intentional delay counters the principle of best effort but can reduce the burstiness of traffic and improve overall network operation - in particular in network with small packet buffers. As a result, pacing improves transport-layer performance, providing a tradeoff example where small amounts of additional delay can significantly increase connection bandwidth. We present a Queue Length Based Pacing (QLBP) algorithm that paces network traffic using a single queue and that can be implemented with small computational and memory overhead. We present a detailed analysis on delay bounds and the quantitative impact of QLBP pacing on network traffic. Through simulation, we show how the proposed pacing technique can improve connection throughput in small-buffer networks.
A simple method for the preparation of horseradish peroxidase (1954)

Research Article| June 01 1954 A simple method for the preparation of horseradish peroxidase R. H. Kenten; R. H. Kenten 1Biochemistry Department, Rothamsted Experimental Station, Harpenden, Herts Search for other works by this author on: This Site PubMed Google Scholar P. J. G. Mann P. J. G. Mann 1Biochemistry Department, Rothamsted Experimental Station, Harpenden, Herts Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1954) 57 (2): 347–348. https://doi.org/10.1042/bj0570347 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation R. H. Kenten, P. J. G. Mann; A simple method for the preparation of horseradish peroxidase. Biochem J 1 June 1954; 57 (2): 347–348. doi: https://doi.org/10.1042/bj0570347 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1954 CAMBRIDGE UNIVERSITY PRESS1954 Article PDF first page preview Close Modal You do not currently have access to this content.
Hebrew Union College Annual, Vol. XXII, Cincinnati, 1949 (1950)

Jacob Edmond. Hebrew Union College Annual, Vol. XXII, Cincinnati, 1949. In: Revue d'histoire et de philosophie religieuses, 30e année n°3,1950. pp. 267-268.
The Telecommunications Handbook: Engineering Guidelines for Fixed, Mobile and Satellite Systems (2015)

This practical handbook and reference provides a complete understanding of the telecommunications field supported by descriptions and case examples throughout Taking a practical approach, The Telecommunications Handbook examines the principles and details of all of the major and modern telecommunications systems currently available to industry and to end-users. It gives essential information about usage, architectures, functioning, planning, construction, measurements and optimisation. The structure of the book is modular, giving both overall descriptions of the architectures and functionali
A hybrid acoustic/electromagnetic technique for locating land mines (1998)

A hybrid technique is presented that simultaneously uses both electromagnetic and acoustic waves in a synergistic manner to detect buried land mines. The system consists of an electromagnetic radar and an acoustic source. The acoustic source causes both the mine and the surface of the earth to be displaced. The electromagnetic radar is used to detect these displacements and, thus, the mine. An experimental and numerical model for the system has been developed.
ChemInform Abstract: Cyclisation of Alkynecarboxylic Acids: Synthesis and Reactions of 6‐Methylene‐1,4‐oxathian‐2‐ones and Their 4,4‐Dioxides. (1990)

Abstract The synthesis of the title compounds (II) and (IV) is described.
Forced degradation studies: an essential tool for the formulation development of vaccines (2013)

Abstract: Forced degradation studies are typically conducted during the early development phase of vaccine candidates to obtain information on potential degradation pathways, support analytical methods development, and identify potential vaccine stabilizers and optimal conditions for long-term storage. The regulatory guidelines for forced degradation regarding biologics have few to no procedural instructions on how to approach forced degradation studies. In this review, we provide an overview of methods used to study forced degradation in vaccines, mechanisms of degradation, analytical methodology, forced degradation examples conducted for vaccine products, and a summary of stabilizers that are used to influence the results of new vaccine candidates. Keywords: vaccine, formulation, stability, pathways of degradation, stabilizers
Adaptive video coding for mobile wireless networks (2002)

Wireless video transmission over a dynamic network requires adaptation to changes in bandwidth, network traffic, and channel characteristics. New computing hardware and algorithms are needed that enable low-power, flexible, adaptive, and robust video communication in hostile environments with no access to an installed communications infrastructure. The coding algorithms we are developing are based on subband decomposition using integer-coefficient filters, and adaptively deliver video at rates between 60 kbits/sec and 600 kbits/sec in accordance with the available bandwidth. Robustness in the variable length coder is obtained by using low-overhead Reed-Solomon block codes, by performing intra-frame coding only, and by using end-of-frame and end-of-subband symbols to maintain both inter- and intra-frame synchronization.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Utilizing battery electric and plug-in hybrids for smart grid operation techniques (2011)

E-Mobility provides a wide potential for diversification of traffic sectors primary energy source. Until now petrol could be seen as the dominating one. The rollout of battery electric vehicles — plug-in-hybrids included — can be supplied by wind, solar, water, and coal and nuclear as the primary energy source. Obviously the rollout is strictly connected to the issue of grid capability to the additional electric load. First investigations show a concentration of charging in the noon and evening hours, which is coincident with common grid load. As a matter of fact there will be an overload on distribution grid devices and voltage dip, especially on low voltages cables, transformers and mid voltage cables. The rate of overload and voltage dip is hardly connected to the amount of supplied electric vehicles as well as to grid topology and galvanic distance between charge points. The following work deals in modeling and optimization basics of the expected electric load “EV” for simulation purposes. An especial architecture for managing EV's with special respect to the German liberalized market will be shown.
Construction of constrained multi-bit flip-flops for clock power reduction (2010)

Based on the elimination feature of redundant inverters in merging 1-bit flip-flops into multi-bit flip-flops, given the congested constraint of unallocated bins and the length constraints of the input and output signals of all the 1-bit flip-flops, an efficient two-phase approach is proposed to obtain the final multi-bit flip-flops. Compared with the original design in the numbers of inverters for two tested examples, the experimental results show that our proposed approach eliminates 68% of inverters to maintain the synchronous designs and saves 19.75% of the clock power on the average for two tested examples in reasonable CPU time.
Production of nanocellulose from native cellulose – Various options utilizing ultrasound (2011)

In this study three different ways of applying ultrasound for the production of nanocellulose from native cellulose were explored. In the first option bleached hardwood kraft pulp was oxidized with the ultrasound (US) assisted TEMPO/NaBr/NaOCl-system (US-TEMPO-system) followed by mechanical separation of nanocellulose. The pulp oxidized by the US-TEMPO-system had higher carboxyls content and ca. 10% increase in nanocellulose yield when compared to the TEMPO-system without sono catalysis. In the second option ultrasound pretreated pulp was oxidized using the TEMPO-system. Although there was no gain in carboxyls content in this process versus the oxidation with TEMPO-system without ultrasound treatment, a higher degree of fibrillation was obtained after ultrasound treatment. In the third case the TEMPO oxidized pulp was subjected to mechanical and ultrasound treatments for nanocellulose production. Under similar treatment time the subsequent ultrasound treatment achieved higher nanocellulose yield than the subsequent mechanical treatment. However, in comparison, the ultrasound treated nanocellulose had lower Rheometer Stresstech viscosity. Furthermore, it was observed that cellulose nanofibrils produced by ultrasound treatment were slightly thinner compared to those produced using the mechanical method.
Plan Based Parallel Complex Event Detection over RFID Streams (2009)

RFID technology holds the promise of real-time identifying, locating and monitoring physical objects. Event detection is the key part of the RFID middleware. In comparison with traditional events, RFID events have the following characteristics: large volume, temporal and spatial, inaccurate etc. In this paper, a high performance hierarchical complex event detecting method is proposed to overcome the drawback of the current RFID complex event detecting methods. Based on query plan, this method uses parallel algorithm at different level to improve the performance. Traditional query language for complex event detection is extended to support hierarchical complex event detection. The experimental study shows that the new method has better performance and flexibility than traditional complex event detection methods.
Flying emplacement of an underwater glider (2017)

An unmanned vehicle is envisioned for multi-modal operation, first as an aircraft, then as an underwater glider. The benefits of a “Flying Sea Glider” are for high-speed flying ingress above the water and then maneuvering in an area of interest as a low-speed, long-endurance underwater glider. This development builds on previous NRL research in multi-modal designs and bio-inspired propulsion systems, with a new emphasis on reducing power required in both air and underwater. Considerations for flying and underwater gliding vehicles are vastly different, despite the aero/hydrodynamic overlap. This paper explores design trades and analysis for a vehicle designed to operate in these two media. To explore the concept, NRL Test Sub 3 was developed and tested. The resulting vehicle demonstrated flight, splashdown, and gliding performance in one vehicle, validating the multimodal flying and gliding design concept. Taken together with an analysis, the demonstration shows the viability of an unmanned “Flying Sea Glider” vehicle.
Morphological and biochemical characteristics in the experimentally treated rats with indigenous synthetical products used as pesticides. (1992)

In acute experimental intoxication with 3 indigenous pesticides (Tripinacloraz, Lemax and Maleic Hydrazide-Na salt) the changes of some biochemical parameters, reflecting the degree of hepatic structural alterations, were studied. The pesticides were administered by gastric gavage in a single dose close to DL50 to Wistar male rats. The morphological alterations were in good correlation with a different hepatocellular levels localization. Reversible morphological lesions (granulovascuolar like dystrophy and circulatory disorders) without any pathological significance on dose-effect correlation induced a progressive response especially on serum ceruloplasmine, leucinaminopeptidase and lactatdehydrogenase.
Mechanical Strength of Durable Press Finished Cotton Fabric. Part IV: Abrasion Resistance (2001)

Durable press (DP) finishing, a process widely used by the textile industry to produce wrinkle-resistant cotton fabrics, causes considerable loss of fabric abrasion resistance. N-methylol compounds such as dimethyloldihydroxylethyleneurea (DMDHEU) are traditional durable press finishing agents. In recent years, multifunctional carboxylic acids such as 1,2,3,4-butanetetracarboxylic acid (BTCA) have been used as nonformaldehyde alternatives. In this research, we investigate the loss in fabric abrasion resistance caused by degradation and crosslinking of cellulose. Treatment of cotton by a polycarboxylic acid or a catalyst for DMDHEU results in a significant loss of its abrasion resistance. The lost abrasion resistance of cotton treated with BTCA is attributed to irreversible acid-catalyzed depolymerization and reversible crosslinking of cellulose molecules. We have removed the crosslinking of BTCA-treated cotton fabric with alkaline hydrolysis, thus determining separately the magnitude of lost fabric abrasion resistance due to the two different factors. For a warp-faced twill weave cotton, the reduced abrasion resistance in the warp direction is more severe than in the filling direction.