gebhart/patrepeval huggingface dataset:
Two Nuclear Dot‐Associated Proteins, PML and SplOO, are Often Co‐Autoimmunogenic in Patients with Primary Biliary Cirrhosis (1995)

The nucleoproteins Sp100 and PML, the first an autoantigen predominant in patients with primary biliary cirrhosis (PBC) and the second a transformation and cell growth suppressing protein aberrantly expressed in promyelocytic leukaemia cells, were recently shown to colocalize in dot-like nuclear domains. Here we analysed whether PML, like Sp100, is also an autoantigen in patients with PBC and other autoimmune diseases, and wether both proteins interact directly. Testing sera from autoimmune patients using an immunoprecipitation assay with radiolabelled PML and an immunofluorescence assay based on a cell line overexpressing PML, autoantibodies (Aabs) against PML were found in the majority o anti-Sp100 Aab positive patients. Only very few patients with PBC or other autoimmune diseases contained anti-PML or anti-Sp100 Aabs exclusively. In contrast to Sp100, immunoreactivity of recombinant PML in immunoblots was only weak and was directed to one region. This suggests that anti-PML Aabs recognize fewer and preferentially conformation-dependent epitopes. In an immunoprecipitation assay using in vitro synthesized Sp100 and PML proteins and Abs to recombinant proteins, no direct interaction was observed. Taken together, these data indicate that Aabs against PML are as highly prevalent and specific for patients with PBC as those against Sp100. The colocalization of these autoantigens and the frequent co-occurrence of the corresponding Aabs might reflect an association of both proteins mediated by one or several other proteins.
Ulcerative vulvitis and balanitis in sheep flocks (Veterinary Record (2008) 163, (86-89)) (2008)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Natural graphite modified with nitrophenyl multilayers as anode materials for lithium ion batteries (2006)

Nitrophenyl multilayers of a few nanometers thickness were covalently attached to the surface of natural graphite via diazonium chemistry. The as-prepared graphite showed great improvements in the initial coulombic efficiency, specific capacity and cyclability as anode materials for lithium ion batteries. Scanning electron microscope and electrochemical impedance measurements revealed that a compact, stable, and uniform solid electrolyte interface (SEI) film formed on the graphite surface. This study may provide a new strategy to modify conventional anode or even cathode materials by molecular design.
Ions and RNA Folding (2005)

The problem of how ions influence the folding of RNA into specific tertiary structures is being addressed from both thermodynamic (by how much do different salts affect the free energy change of folding) and structural (how are ions arranged on or near an RNA and what kinds of environments do they occupy) points of view. The challenge is to link these different approaches in a theoretical framework that relates the energetics of ion-RNA interactions to the spatial distribution of ions. This review distinguishes three different kinds of ion environments that differ in the extent of direct ion-RNA contacts and the degree to which the ion hydration is perturbed, and summarizes the current understanding of the way each environment relates to the overall energetics of RNA folding.
Recyclability and reutilization of carbon fiber fabric/epoxy composites (2011)

Solid carbon fiber/epoxy laminates manufactured by liquid resin infusion of twill fabric reinforcement are recycled in a bath of boiling sulfuric acid to separate the fibers from the matrix. The recycled reinforcement consists of long fibers arranged in a random, entangled mat. Using the same epoxy matrix and infusion materials and process, the recycled fibers are reutilized to manufacture solid laminates. The physical properties of the recycled laminates are evaluated by means of pulse-echo ultrasound, visual microscopy, and fiber volume content. The average fiber volume content of the recycled laminates is 33%, compared to the 62% of the twill laminates. The mechanical properties of the recycled composite include tension modulus and strength, compression modulus and strength, three-point bend flexure strength, and short beam shear strength. The properties are compared against the values of the twill reinforcement with quasi-isotropic stacking sequence. Results show that the recycled material offers promising elastic properties and strength values, similar to those of advanced carbon fiber sheet molding compounds, and therefore can be used as structural material.
A Novel Class of Highly Potent and Selective A<sub>1</sub> Adenosine Antagonists:  Structure−Affinity Profile of a Series of 1,8-Naphthyridine Derivatives (2000)

A series of 1,8-naphthyridine derivatives (12-36), bearing a phenyl group in position 2 and various substituents in positions 4 and 7, were synthesized in an attempt to obtain potent, selective antagonists for the A1 adenosine receptor subtype. The compounds were tested to evaluate their affinity for A1 compared with A2A and A3 adenosine receptor subtypes. In binding studies in bovine brain cortical membranes, most of the compounds showed an affinity for A1 receptors in the low nanomolar range and two in the subnanomolar range with an interesting degree of A1 versus A2A and A3 selectivity. Comparison of the 4-substituted derivatives indicated that 4-OH substitution, with a 4-quinoid structure, causes an increase in the A1 and A2A affinity and generally also in A1 selectivity. The kind of substitution in position 7 can greatly modulate the affinity: the most interesting substituents in this position seemed to be electron-withdrawing groups; in particular the 7-chloronaphthyridine 25d showed a remarkable selectivity (A2A/A1 ratio of 670, A3/A1 ratio of 14,000) associated with a higher A1 affinity (Ki = 0.15 nM). NMR studies on these compounds 12-36 indicated that the 4-OH-substituted ones prefer the tautomer in which the oxygen in position 4 is in the quinoid form and the nitrogen in position 1 is protonated. Theoretical calculations are in agreement with the NMR data.
Generation speed and reconstructed image quality enhancement of a long-depth object using double wavefront recording planes and a GPU (2014)

A method for fast computer hologram generation for long-depth objects using double wavefront recording planes (WRPs) and a graphics-processing unit (GPU) is presented. The WRPs are placed between the object and the hologram plane. Each WRP records the wavefront from a section of the object. Double WRPs can provide a shorter calculation time and enhanced reconstructed image quality compared with a single WRP, especially for long-depth objects. The average generation speed of two WRPs is 2.5 times that of one WRP. The correlation efficiency of the reconstructed layer relative to the original is 94% for two WRPs and 88.3% for one WRP at the close depth layer.
Service agents and virtual enterprises: a survey (2003)

Implementing specific principles of academic software agents could help us build on Web service standards and finally realize the promise of a virtual enterprise.
Enhanced Rates of Photocatalytic Degradation of an Azo Dye Using SnO2/TiO2 Coupled Semiconductor Thin Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnhanced Rates of Photocatalytic Degradation of an Azo Dye Using SnO2/TiO2 Coupled Semiconductor Thin FilmsK. Vinodgopal and Prashant V. KamatCite this: Environ. Sci. Technol. 1995, 29, 3, 841–845Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/es00003a037https://doi.org/10.1021/es00003a037research-articleACS PublicationsRequest reuse permissionsArticle Views3434Altmetric-Citations498LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assembly of laminin isoforms by triple- and double-stranded coiled-coil structures (1991)

Conference Article| November 01 1991 Assembly of laminin isoforms by triple- and double-stranded coiled-coil structures Jürgen Engel; Jürgen Engel *Department of Biophysical Chemistry, Biozentrum of the University of Basel, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Irene Hunter; Irene Hunter *Department of Biophysical Chemistry, Biozentrum of the University of Basel, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Therese Schulthess; Therese Schulthess *Department of Biophysical Chemistry, Biozentrum of the University of Basel, CH-4056 Basel, Switzerland Search for other works by this author on: This Site PubMed Google Scholar Konrad Beck; Konrad Beck †Institute for Biophysics, University of Linz, A-4040 Linz, Austria Search for other works by this author on: This Site PubMed Google Scholar Tony W. Dixon; Tony W. Dixon ‡Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand Search for other works by this author on: This Site PubMed Google Scholar David A. D. Parry David A. D. Parry ‡Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1991) 19 (4): 839–843. https://doi.org/10.1042/bst0190839 Article history Received: July 25 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Jürgen Engel, Irene Hunter, Therese Schulthess, Konrad Beck, Tony W. Dixon, David A. D. Parry; Assembly of laminin isoforms by triple- and double-stranded coiled-coil structures. Biochem Soc Trans 1 November 1991; 19 (4): 839–843. doi: https://doi.org/10.1042/bst0190839 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ECM, extracellular matrix, EHS, Engelbreth-Holm-Swarm © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
The Strain Index: A Proposed Method to Analyze Jobs For Risk of Distal Upper Extremity Disorders (1995)

Based on existing knowledge and theory of the physiology, biomechanics, and epidemiology of distal upper extremity disorders, a semiquantitative job analysis methodology was developed. The methodology involves the measurement or estimation of six task variables (intensity of exertion, duration of exertion per cycle, efforts per minute, wrist posture, speed of exertion, and duration of task per day); assignment of an ordinal rating for each variable according to exposure data; then assignment of a multiplier value for each variable. The Strain Index is the product of these six multipliers. Preliminary testing suggests that the methodology accurately identifies jobs associated with distal upper extremity disorders versus jobs that are not; however, large-scale studies are needed to validate and update the proposed methodology.
Use of vancomycin silica stationary phase in packed capillary electrochromatography: III. Enantiomeric separation of basic compounds with the polar organic mobile phase (2002)

The separation of basic compounds into their enantiomers was achieved using capillary electrochromatography in 50 or 75 microm inner diameter (ID) fused-silica capillaries packed with silica a stationary phase derivatized with vancomycin and mobile phases composed of mixtures of polar organic solvents containing 13 mM ammonium acetate. Enantiomer resolution, electroosmotic flow, and the number of theoretical plates were strongly influenced by the type and concentration of the organic solvent. Mobile phases composed of 13 mM ammonium acetate dissolved in mixtures of acetonitrile/methanol, ethanol, n-propanol, or isopropanol were tested and the highest enantioresolutions were achieved using the first mobile phase, allowing the separation of almost all investigated enantiomers (9 from 11 basic compounds). The use of capillaries with different ID (50 and 75 microm ID) packed with the same chiral stationary phase revealed that a higher number of theoretical plates and higher enantioresolution was achieved with the tube with lowest ID.
The Growth Physiology of Pinguiococcus pyrenoidosus With an Emphasis on Fatty Acids (2002)

The Pinguiophyceae are a new class of photosynthetic stramenopiles consisting of five monotypic genera. These chromophyte microalgae have an unusually high percentage of polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA), though the function of these compounds within the cell is unknown. This high PUFA content and composition make these algae favorable candidates for mariculture and for the nutraceutical industry. Chosen for this study was one member of this class, Pinguiococcus pyrenoidosus, which has been observed to possess lipid-like, electron-transparent vacuoles during late stationary phase growth. This study investigated the physiological ecology and fatty acid chemistry of Pinguioco. pyrenoidosus grown in batch and continuous culture. The results revealed that Pinguioco. pyrenoidosus appears to be an obligate phototroph, uses ammonium as a nitrogen source, and can tolerate a wide range of salinity. This alga contains a high concentration of EPA and other PUFAs including docosapentaenoic acid (DPA), which was previously undetected in this species. PUFA content and composition increase at lower temperatures and in late stationary phase growth. These data suggest that Pinguioco. pyrenoidosus utilizes PUFAs as both storage compounds and regulators of membrane fluidity. Maximum PUFA concentration was found in batch culture during late stationary phase growth whereas maximum PUFA production rates were found in continuous culture and reached a plateau at a growth rate of ~50% umax.
Plasma Transforming Growth Factor α and Amphiregulin Protein Levels in NCIC Clinical Trials Group BR.21 (2010)

High baseline amphiregulin is a poor prognostic factor, whereas high baseline TGF-α predicts for lack of benefit from erlotinib in advanced NSCLC.
Vascular update: Morphogenesis, tumors, malformations, and molecular dimensions (2006)

This vascular review is organized under the following headings: vasculogenesis and angiogenesis; vascular endothelial growth factors, their receptors, TIE receptors, and angiopoietins; other factors in blood vessel formation; parallel patterning in blood vessels and nerves; physiological and pathological neovascularization; the role of VEGF receptors in metastasis; anti-angiogenic therapy for tumors; association of blood vessels with fat; vascular malformations and vascular tumors; infantile hemangiomas; congenital hemangiomas; lymphatic malformations; molecular characteristics of some disorders with vascular malformations; Kasabach-Merritt phenomenon; Sturge-Weber syndrome, Klippel-Trenaunay syndrome, and Parkes Weber syndrome; diagnostic and laboratory studies; and future perspectives.
Inhibition of Erythrocyte Cation Channels by Erythropoietin (2003)

Recombinant human erythropoietin therapy is used to counteract anemia that is the result of renal insufficiency. It stimulates the formation of peripheral blood erythrocytes by inhibiting apoptosis of erythrocyte precursor cells. Mature erythrocytes have similarly been shown to undergo apoptosis. Hyperosmotic shock and Cl(-) removal activate a Ca(2+)-permeable, ethylisopropylamiloride-inhibitable cation channel. The subsequent increase of cytosolic Ca(2+) activates a scramblase that breaks down cell membrane phosphatidylserine asymmetry, leading to annexin binding. Studied was whether channel activity and erythrocyte cell death are regulated by erythropoietin. Scatchard plot analysis disclosed low-abundance, high-affinity binding of (125)I-erythropoietin to erythrocytes. Whole cell patch clamp experiments revealed significant inhibition of the ethylisopropylamiloride-sensitive current by 1 U/ml erythropoietin. Cl(-) removal triggered annexin binding, an effect abrogated by erythropoietin (1 U/ml) but not by GM-CSF (10 ng/ml). Osmotic shock (700 mOsm) stimulated annexin binding within 24 h in the majority of the erythrocytes, an effect blunted by erythropoietin (1 U/ml) but not by GM-CSF (10 ng/ml). In the nominal absence of Ca(2+), the effect of osmotic shock was blunted and the effect of erythropoietin abolished. In hemodialysis patients, intravenous administration of erythropoietin (50 IU/kg) within 4 h decreased the number of annexin binding circulating erythrocytes. Erythropoietin binds to erythrocytes and inhibits volume-sensitive erythrocyte cation channels and thus the breakdown of phosphatidylserine asymmetry after activation of this channel. The effect could prolong the erythrocyte lifespan and may contribute to the enhancement of the erythrocyte number during erythropoietin therapy in dialysis patients.
Reliability prediction for service-oriented computing environments (2006)

A key issue in the development of service-oriented computing applications is the dynamic and efficient prediction of their overall quality to appropriately drive the selection and assembly of services. This article focuses on the reliability quality measure and presents an implementation of a reliability prediction methodology that respects SOC's decentralization and autonomy principles. Despite the focus on reliability, you can extend the architecture to the prediction of other quality measures
Laser‐irradiation effect on poly(vinyl alcohol) films doped with nanometer‐sized CdS particles: Ablation and third‐harmonic generation (1993)

Abstract Ultrasmall CdS particles, whose average size was controlled by thiols to range from 2 to 4 nm, were embedded in poly(vinyl alcohol) films. Shift of the fluorescence peak associates with the shift of the absorption threshold of the films, and the fluorescence intensity increases with the decrease in the size of CdS. Laser ablation at 308 nm was investigated by monitoring the emission spectra. Third‐harmonic generation was measured for various sizes of CdS particles, and the optical nonlinearity in the nonresonance region was found to remain almost constant in the diameter range studied. © 1993 John Wiley & Sons, Inc.
Techniques of CT Colonography (Virtual Colonoscopy) (1999)

Colorectal cancer is a leading cause of death in older adults, which usually involves a long-term progressive change of normal mucosa into adenomatous polyps and then cancer. The detection and treatment of this disease in an early stage can lead to a cure in most cases by simply removing the polyp. Computed tomographic colonography (CTC), also referred to as virtual colonoscopy (VC), is a recent advance that gives an intraluminal visualization of the colon that is similar to endoscopy. VC requires fast 3D display (at least 10 frames/sec) of the colon's mucosal surface on a computer screen. Spiral/helical computer tomography is used to gather 3D volume data prior to display. CTC has been demonstrated to be promising for colorectal cancer screening. Studies on unraveling of the colon are underway to map the convoluted tubular structure into a straightened and flattened image volume for global visualization. In this article, we review the current status of CTC with an emphasis on image processing and visualization algorithms. Clinical assessment results of existing techniques are summarized. Practical issues and future perspectives are also discussed.
The Beneficial Effects α‐Cyclodextrin on Blood Lipids and Weight Loss in Healthy Humans (2010)

α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. It has previously been reported that early intervention with Mirafit fbcx, a trademarked name for α-CD, has beneficial effects on weight management in obese individuals with type 2 diabetes, and that it preferentially reduces blood levels of saturated and trans fats in the LDL receptor knockout mice. The current investigation involves overweight but not obese nondiabetic individuals and was intended to confirm the effects of α-CD on both weight management and improving blood lipid levels. Forty-one healthy adults (age: 41.4 ± 13.6 years) participated in this 2-month, double-blinded, crossover study. In 28 compliant participants (8 males and 20 females), when the active phase was compared to the control phase, there were significant decreases in body weight (-0.4 ± 0.2 kg, P < 0.05), serum total cholesterol (mean ± s.e.m., -0.295 ± 0.10 mmol/l, 5.3%, P < 0.02) and low-density lipoprotein (LDL) cholesterol (-0.23 ± 0.11 mmol/l, -6.7%, P < 0.05). Apolipoprotein B (Apo B) (-0.0404 ± 0.02 g/l, -5.6%, P = 0.06) and insulin levels also decreased by 9.5% (-0.16 ± 0.08 pmol/l, P = 0.06) while blood glucose and leptin levels did not change. These results suggest that α-CD exerts its beneficial health effects on body weight and blood lipid profile in healthy nonobese individuals, as previously reported in obese individuals with type 2 diabetes.
Sweat Rates, Sweat Sodium Concentrations, and Sodium Losses in 3 Groups of Professional Football Players (2010)

The BK sweated at lower rates than did the midsized LB/QB and large LM, but LB/QB sweated similarly to LM. Sweat sodium concentration and daily sodium losses ranged considerably. Heavy, salty sweaters require increased dietary consumption of sodium during preseason.
Expression of AT(1a) mRNA in rat hepatic stellate cells and its effects on cell growth collagen production. (2004)

Activated hepatic stellate cells (HSCs) play important roles in hepatic fibrosis. Studies on HSCs activation in vitro have shown that this process is regulated by a wide variety of growth factors and cytokines. 1 Recent data indicate that Ang II is responsible for the mechanisms of myocardial fibrosis and kidney fibrosis; but there are only few reports on hepatic fibrosis. 2 - 8 In this study we hypothesized that angiotensin II (Ang II) could play a role in liver fibrosis and that AT 1 a antagonist might prevent liver fibrosis by attenuating the number and/or fibrogenetic potential of extracellular matrix-producing HSCs. To investigate these hypotheses, we confirmed that AT 1 a mRNA was expressed in rat HSCs and its effects on cell growth and collagen production.