gebhart/patrepeval huggingface dataset:
Perspectives on the mitochondrial multiple conductance channel (1996)

A multiple conductance channel (MCC) with a peak conductance of over 1 nS is recorded from mitoplasts (mitochondria with the inner membrane exposed) using patch-clamp techniques. MCC shares many general characteristics with other intracellular megachannels, many of which are weakly selective, voltage-dependent, and calcium sensitive. A role in protein import is suggested by the transient blockade of MCC by peptides responsible for targeting mitochondrial precursor proteins. MCC is compared with the peptide-sensitive channel of the outer membrane because of similarities in targeting peptide blockade. The pharmacology and regulation of MCC by physiological effectors are reviewed and compared with the properties of the pore hypothesized to be responsible for the mitochondrial inner membrane permeability transition.
Nonreceptor Tyrosine Phosphatases in Cellular Signaling:  Regulation of Mitogen-Activated Protein Kinases (2001)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonreceptor Tyrosine Phosphatases in Cellular Signaling: Regulation of Mitogen-Activated Protein KinasesXiao-Li Zhan, Matthew J. Wishart, and Kun-Liang GuanView Author Information Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, and Department of Biological Chemistry and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109 Cite this: Chem. Rev. 2001, 101, 8, 2477–2496Publication Date (Web):July 17, 2001Publication History Received23 October 2000Published online17 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/cr000245uhttps://doi.org/10.1021/cr000245uresearch-articleACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views393Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cell and molecular biology,Genetics,Monomers,Peptides and proteins,Post-translational modification Get e-Alerts
Mutual Fund Performance and Manager Style (2001)

In this analysis of the relationship between equity mutual fund performance and manager style, two questions are addressed. First, does any investment style generate abnormal returns on average? Second, when funds are grouped by equity style, does any style exhibit performance persistence? The answers from this study are as follows: None of the styles earned positive abnormal returns during the 1965–98 sample period, and value funds realized negative abnormal returns of about 2.75 percentage points a year. Some evidence was found of short-run performance persistence among the best-performing growth funds and among the worst-performing small-cap funds.
Terminal glycosyltransferase activity: a selective role in cell adhesion (1993)

FOR DECADES, knowledge about blood group antigens has constituted the basis for sound transfusion practice. Although blood group serology may seem a research area largely restricted to the surface antigens on human red blood cells (and platelets), many of the known blood group antigens have a far broader tissue expression than generally acknowledged. The ABO blood group system, discovered in 1900 by Karl Landsteiner, is, for instance, also found on other cell types (mainly of epithelial origin) and evolves even earlier in these tissues than on erythrocytes. The specificity of many (histo-)blood group antigens relies on subtle differences in sugar components linked to membrane lipids and/or proteins. Hence, a great deal of biochemical insight in glycosyltransferase function (eg, optimal conditions for enzymatic activity, substrate requirements, and product formation) has been generated in relation to the carbohydrate antigens on erythrocytes. Although sugar determinants resulting from enzymatic transfer of L-fucose residues are of relatively minor importance for transfusion medicine, this review will show that recent discoveries in the adhesion field warrant a better understanding of the fucosyltransferase (FT) (sub)types and their tissue-restricted expression pattern with respect to inflammatory responses and lymphocyte traffic.
Evaluating the energy-consumption reduction in a MANET by dynamically switching-off network interfaces (2002)

The design of energy-efficient routing algorithms is a fundamental problem in a mobile ad-hoc network (MANET) where battery energy is a limited resource. We evaluate a power-conserving algorithm, based on the RTS/CTS dialogue of the IEEE 802.11 standard which dynamically switches off the radio network interface card of nodes when they are neither transmitting nor receiving a packet. We evaluate the algorithm through simulations over four well-known routing algorithms: dynamic source routing (DSR), ad-hoc on demand distance vector (AODV), temporally-ordered routing algorithm (TORA), and destination-sequenced distance-vector routing (DSDV). The obtained results indicate that for all the evaluated routing protocols, the power savings are similar and range between 25 per cent and 60 per cent of the total energy.
An 18-Mb, 12.3-GB/s CMOS pipeline-burst cache SRAM with 1.54 Gb/s/pin (1999)

An 18-Mbit CMOS pipeline-burst cache SRAM achieves a 12.3-Gbyte/s data transfer rate with 1.54-Gbit/s/pin I/O's. The SRAM is fabricated on a 0.18-/spl mu/m CMOS technology. The 14.3/spl times/14.6-mm/sup 2/ SRAM chip uses a 5.59-/spl mu/m/sup 2/, six-transistor cell. Circuit techniques used for achieving high bandwidth include fully self-timed array architecture, segmented hierarchical sensing with separated global read/write bitlines in different metal layers, a high-speed data-capture technique, a reduced-swing output buffer, and a high-sensitivity, high-bandwidth input buffer.
High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma (2015)

High DEPTOR expression is an independent prognostic biomarker indicating a worse prognosis for patients with ESCC.
Compact spectrum splitting photovoltaic module with high efficiency (2010)

Abstract We have designed, fabricated, and tested a small, integrated photovoltaic module comprised of two separately‐contacted, high efficiency, multijunction solar cells and non‐imaging optics that both concentrate and spectrally split the incoming light. This hybrid design allows us to individually optimize the tandem cells and optical elements. The system has a measured module efficiency, including optical and packaging losses but not power combination losses, of 38.5 ± 1.9% under the AM1.5 direct terrestrial spectrum. The internal optics concentrate the light by a factor of approximately 20. We find excellent agreement between the modeled and measured performance. This is the highest confirmed conversion efficiency demonstrated for a photovoltaic module. Copyright © 2010 John Wiley & Sons, Ltd.
Elgar and his publishers (2005)

‘Elgar Brothers’, the music shop at 10 High Street, Worcester, became a mounting embarrassment to Elgar as his composing confidence increased and he aspired to a higher social position. Retail trade might have been acceptable as background to his Helen Weaver engagement. But there were rumours also of a connection with Sarah-Anne Wilkinson Newholme made while staying with Dr Charles Buck in Yorkshire, then of an attempted engagement to Gertrude Walker, musical daughter of the rector and squire at Abbots Norton, with whom Elgar shared many a concert platform, and who went on to breed dogs and become local secretary of the British Shakespeare Society. Above all there was Alice Roberts, a major-general's daughter born in India, whose social concerns in her early writings became rather, after her marriage to Elgar on 8 May 1889, a determination to raise her composer husband out of the sphere he was born in. Occasionally Elgar's mother might visit the home of the couple; occasionally the father would be summoned to tend a piano; but there is no record of the parents being invited together. To anticipate the Gerontius premiere, F. G. Edwards of the Musical Times planned a major article on Elgar. Alice Elgar, in a letter to Edwards of 18 September 1900, put her foot down firmly on certain matters, and notably the ‘shop’; ‘Then as E. has nothing to do with the business in Worcester would you please leave out details which do not affect him&with which he has nothing to do – His interests being quite unconnected with business.’
Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers (2015)

While cross-linked hemoglobin (Hb) tetramers can deliver oxygen as a supplement to red cells, they also cause unacceptable increases in blood pressure, presumably from their penetration of the linings of blood vessels (endothelia) where the internal hemes bind endogenous nitric oxide (NO). This penetration would lower the local concentration of NO that normally induces vasodilation. Enlarging the effective size of the oxygen-carrying protein by coupling two Hbs can prevent their extravasation. Efficient and selective protein-protein coupling to produce those species has been a significant challenge. Introduction of an azide within a protein provides a directionally-oriented reaction site for utilization of the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) in the protein-protein-coupling process based on solubility-directed sequential addition to a bis-alkyne. However, it is known that Hb with an azide-containing cross-link between α-subunits is unreactive in CuAAC. To direct reaction away from the α-subunits of Hb, a specific fumaryl cross-link is installed exclusively between the most reactive sites on those subunits, thereby blocking the α-99 lysyl groups and preventing any further reaction. This modification allows installation of an azide-containing cross-link exclusively between lysine-82 ε-amino groups of the β-subunits of Hb. The multiply interconnected sites establish a geometry that permits initial interfacial interaction of the cross-linked Hb-azide with Cu(i) and a bis-alkyne. After coupling, the protein-linked azide product undergoes CuAAC at the remaining alkyne with a second cross-linked Hb-azide, producing a fully functional cross-linked Hb bis-tetramer whose oxygenation and structural properties include cooperativity and oxygen affinity that should be suitable for testing as an alternative to red cells in transfusions.
Density, Porosity, and Compaction of Sedimentary Rocks (1930)

An efficient laboratory method of obtaining the bulk volume of a chunk sample of rock is explained. The relation between depth of burial and the density, porosity, and compaction of different types of sediment is discussed and data are presented. These relations can be expressed by exponential equations. Compaction as a cause of structure is substantiated by computation and data. A table is given showing the relation in north-central Oklahoma between depth of burial, height of buried hills, and closure resulting from compaction. An approximate idea of the depth of material eroded from a given area may be obtained by density or porosity studies.
Studies on the Volatile Compounds of Roasted Spotted Shrimp (2005)

The aroma of spotted shrimp (Sergia lucence Hansen) was analyzed upon roasting to determine the components that constitute the characteristic roasted shrimp flavor. Our analyses resulted in the identification of ca. 200 volatiles, including high-impact sulfur and nitrogen compounds. In addition, we synthesized all possible stereoisomers of the pyrrolidine derivatives 1 and 4, and of the imine derivatives 16 and 18–20, which are very characteristic for the aroma. The odor evaluation of these chemicals revealed distinct differences, each possessing different aroma characteristics.
An improved palladium-based DMFCs cathode catalyst (2004)

A novel carbon-supported palladium-rich Pd3Pt1/C catalyst prepared by a modified polyol process showed a better cell performance than Pt/C in direct methanol fuel cells, which may be attributed to palladium's inactivity to methanol electro-oxidation while exhibiting good performance to oxygen reduction reaction.
Age-related Changes in Compensatory Stepping in Response to Unpredictable Perturbations (1996)

Given the functional significance of base-of-support changes as a strategy for preserving stability and the age-related differences presently revealed, assessment of the capacity to preserve stability against unpredictable perturbation, and specific measures such as the occurrence or placement of multiple steps, may prove to be a significant predictor of falling risk and an important outcome in evaluating or developing intervention strategies to prevent falls.
Extension of DNA in a Nanochannel as a Rod-to-Coil Transition (2013)

DNA confinement in nanochannels is emerging as an important tool for genomics and an excellent platform for testing the theories of confined wormlike polymers. Using cutting-edge, large scale Monte Carlo simulations of asymptotically long wormlike chains, we show that, in analogy to the rod-to-coil transition for free wormlike polymers, there exists a universal, Gauss-de Gennes regime that connects the classic Odijk and de Gennes regimes of channel-confined chains. For DNA in a nanochannel, this Gauss-de Gennes regime spans practically the entire experimentally relevant range of channel sizes, including the nanochannels used in an incipient genome mapping technology.
Chroniques génomiques (1990)

Chroniques génomiquesOù l'auteur explicite ses intentions.S'agit-il de séquence ou plutôt de carte ?Le point sur les orientations actuelles.
Structuring lectures in massive open online courses (MOOCs) for efficient learning by linking similar sections and predicting prerequisites (2015)

The increasing popularity of Massive Open Online Courses (MOOCs) has resulted in huge number of courses available over the Internet. Typically, a learner can type a search query into the look-up window of a MOOC platform and receive a set of course suggestions. But it is difficult for the learner to select lectures out of those suggested courses and learn the desired information efficiently. In this paper, we propose to structure the lectures of the various suggested courses into a map (graph) for each query entered by the learner, indicating the lectures with very similar content and reasonable sequence order of learning. In this way the learner can define his own learning path on the map based on his interests and backgrounds, and learn the desired information from lectures in different courses without too much difficulties in minimum time. We propose a series of approaches for linking lectures of very similar content and predicting the prerequisites for this purpose. Preliminary results show that the proposed approaches have the potential to achieve the above goal.
Carbon−Carbon Bond Forming Solid-Phase Reactions (1999)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon−Carbon Bond Forming Solid-Phase ReactionsBeth A. Lorsbach and Mark J. KurthView Author Information Department of Chemistry, University of California, Davis, California 95616 Cite this: Chem. Rev. 1999, 99, 6, 1549–1582Publication Date (Web):May 20, 1999Publication History Received3 August 1998Revised23 April 1999Published online20 May 1999Published inissue 9 June 1999https://pubs.acs.org/doi/10.1021/cr970109yhttps://doi.org/10.1021/cr970109yresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views2638Altmetric-Citations194LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Anions,Hydrocarbons,Organic polymers,Reaction products Get e-Alerts
The Bisphenol A Experience: A Primer for the Analysis of Environmental Effects on Mammalian Reproduction1 (2009)

It is increasingly evident that environmental factors are a veritable Pandora's box from which new concerns and complications continue to emerge. Although previously considered the domain of toxicologists, it is now clear that an understanding of the effects of the environment on reproduction requires a far broader range of expertise and that, at least for endocrine-disrupting chemicals, many of the tenets of classical toxicology need to be revisited. Indeed, because of the wide range of reproductive effects induced by these chemicals, interest among reproductive biologists has grown rapidly: in 2000, the program for the annual Society for the Study of Reproduction meeting included a single minisymposium on the fetal origins of adult disease, one platform session on endocrine disruption, and 23 toxicology poster presentations. In contrast, environmental factors featured prominently at the 2009 meeting, with strong representation in the plenary, minisymposia, platform, and poster sessions. Clearly, a lot has happened in a decade, and environmental issues have become an increasingly important research focus for reproductive biologists. In this review, we summarize some of the inherent difficulties in assessing environmental effects on reproductive performance, focusing on the endocrine disruptor bisphenol A (BPA) to illustrate important emerging concerns. In addition, because the BPA experience serves as a prototype for scientific activism, public education, and advocacy, these issues are also discussed.
Physical and electronic properties in multiwalled carbon nanotube–poly(3‐dodecylthiophene) nanocomposites (2009)

Abstract The properties of nanocomposites of dodecyl ester functionalized multiwalled carbon nanotube (FMWNT) and four poly(3‐dodecyl thiophene) (P3DDT) samples with different molecular weight and chain regioregularity are reported here. Uniform dispersion of FMWNT in the composites is evident from TEM study. π–π and CH–π interactions are evident from FTIR spectra in the low molecular weight ( M w = 8 × 10 4 ) and high regiorandom (head‐tail = 69 mol %) P3DDT (ILM) composites; however, such interactions are not so prominent for other P3DDTs. Wide‐angle X‐ray scattering patterns indicate intact interchain lamellar structure of P3DDT in the composites. DSC study shows decrease of main chain melting peak of P3DDT (ILM) with increasing F‐MWNT content but the decrease is lower with higher molecular weight and higher regioregular samples. Dynamic mechanical analyzer study indicates that there is no significant change in the T g , T β , and T γ transition temperature with FMWNT concentration indicating almost ideal mixing of the components. The percent increase of G ′ increases with increasing FMWNT loading and also with temperature showing an 84% increase in storage modulus at –20 °C for ILM12 samples. The UV–vis spectrum indicates a decrease in band gap with FMWNT concentration for ILM composites, however, it is negligible with other P3DDTs. Photoluminescence quenching and multiple emission peaks occur in the composites. dc‐Conductivity of the composites increases by two orders and current‐voltage ( I – V ) curves show memory effect only in ILM‐MWNT composites. The I – V curves of other P3DDT nanocomposites exhibit rectification property. Quantitative explanation of electronic properties has been afforded from the band energy and work function values. So, the electronic properties of the nanocomposite can be tuned by changing the molecular weight, regioregularity, and concentration of FMWNT. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1412–1425, 2009
MOLECULAR DYNAMICS SIMULATION ON HYDROGEN STORAGE IN METALLIC NANOPARTICLES (2009)

Hydrogen storage in a metallic nanoparticle was simulated by classical molecular dynamics. Distribution of hydrogen atoms inside nanoparticle was investigated by changing length and energy parameters of metal– H bonds. Hydrogen atoms diffused into the particle and distributed homogeneously in case of weak metal– H bonds. In case of strong metal– H bonds, a hydrogen-rich surface layer was observed which suppresses the inward diffusion of hydrogen atoms. Structural modification of nanoparticle accompanied by grain boundary formation due to hydrogen loading was also observed. These variations in dynamical and structural features are considered to affect the hydrogen storage properties in nanoparticles.
<title>Thin-film micromirror array (TMA) for high luminance and cost-competitive information display systems</title> (1999)

The thin-film micromirror array (TMA) is a new reflective type spatial light modulator fabricated with the optical microelectromechanical system (MEMS) technology. Micromachined thin-film piezoelectric actuators are used to control the tilt angle of each micromirror, which simply defines the gray scale of the matching screen pixel when it reflects the light for the lamp. The hidden actuator design with the two-sacrificial layer process provides the highest fill factor and flat enough micromirrors resulting the system optical efficiency of 22 percent, which is the highest efficiency among all the reflective and transmissive light modulators in the world at the present time. A working projector prototype of 5,400 true ANSI lumen is realized with three TMA modules and a 1 kW Xenon lamp. TMA projector prototype is brighter than any competing technology projectors in the world at the same lamp power, at least three times or more. The simplicity of the underlying principle and the highest optical efficiency of TMA enables high-brightness and cost competitive projection displays which has been impossible in the past. At the same cost, more brightness can be provided for the high-end large venue projectors. At the same brightness, lower cost products can be provided as desktop projectors for no-more-darkroom digital presentation and affordably priced HDTVs.
Mental health. Right approach. (1997)

The care programme approach for people with long-term mental illness appears to have been a key factor in increasing the average length of stay in psychiatric wards. In one trust the average length of stay has almost doubled since 1991. The need for complex care plans to be in place before patients are discharged, and the need for multidisciplinary meetings, can slow up discharge. A new model drawn up by the trust aims to cut down on delays by involving community services at the time of admission and using a care plan which is common both to the hospital and community.