gebhart/patrepeval huggingface dataset:
An examination of the transition of the Arjuna distributed transaction processing software from research to products (2002)

The Arjuna transaction system began life in the mid 1980s as an academic project to examine the use of object-oriented techniques in the development of fault-tolerant systems; over 15 years later it is now a Hewlett-Packard product in its own right and is also embedded in several other offerings from HP. In addition, many of the original developers of Arjuna have accompanied the system on its journey and had first hand experience in taking this academic research vehicle into a commercial environment. At times the transition has been neither easy nor smooth but it has been interesting from many different perspectives. In this paper we shall attempt to give an overview of how this occurred and illustrate some of the lessons we have learned over the years.
Toxicity of <i>Nerium oleander</i> in the Monkey (<i>Cebus apella</i>) (1974)

The toxic effects of Nerium oleander were evaluated in capuchin monkeys ( Cebus apella) by examination of clinical signs, hematologic and serum chemical values, and gross and microscopic lesions. Dried and ground oleander leaves were given at intervals of 48 h in doses of 30, 7.5, and 3 mg/kg body weight. The cumulative lethal dose ranged from 30 to 60 mg/kg body weight in monkeys that were given doses of 30 and 7.5 mg/kg body weight. Monkeys that received doses of 3 mg/kg body weight (total cumulative dose: 60 mg/kg) survived. Clinical signs were vomiting, salivation, polyuria, bradycardia, vaginal hemorrhage, abortion, anorexia, constipation, loss of body weight, narcosis, restlessness, weakness, and shallow and rapid respirations. Changes in blood values were leukocytosis; neutrophilia; increased potassium, glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, blood urea nitrogen and α-globulins; reticulo-cytopenia; and decreased calcium, glucose, total serum protein, albumin, γ-globulin levels and albumin-globulin ratios. Hemorrhages, degeneration, or necrosis, or all of these, were observed in the heart, gastrointestinal tract, skeletal muscles, ovaries, adrenal glands, liver, kidneys, and pancreas. The organ weights of the pancreas were significantly reduced. Adrenal weights were significantly increased in monkeys that received the highest dose level.
Sulphation of hirudin in BHK cells (1990)

Hirudin, a thrombin inhibitor of the leech, was expressed in BHK cells; the alpha 1-antitrypsin signal peptide was used to direct secretion into the culture medium. The recombinant hirudin so produced inhibited thrombin and was shown by labelling experiments with [35S]sulphate to have been posttranslationally modified.
A Role for the β Isoform of Protein Kinase C in Fear Conditioning (2000)

The protein kinase C family of enzymes has been implicated in synaptic plasticity and memory in a wide range of animal species, but to date little information has been available concerning specific roles for individual isoforms of this category of kinases. To investigate the role of the beta isoform of PKC in mammalian learning, we characterized mice deficient in the PKC beta gene using anatomical, biochemical, physiological, and behavioral approaches. In our studies we observed that PKC beta was predominantly expressed in the neocortex, in area CA1 of the hippocampus, and in the basolateral nucleus of the amygdala. Mice deficient in PKC beta showed normal brain anatomy and normal hippocampal synaptic transmission, paired pulse facilitation, and long-term potentiation and normal sensory and motor responses. The PKC beta knock-out animals exhibited a loss of learning, however; they suffered deficits in both cued and contextual fear conditioning. The PKC expression pattern and behavioral phenotype in the PKC beta knock-out animals indicate a critical role for the beta isoform of PKC in learning-related signal transduction mechanisms, potentially in the basolateral nucleus of the amygdala.
Electrodeposition of Copper on Ruthenium Oxides and Bimetallic Corrosion of Copper/Ruthenium in Polyphenolic Antioxidants (2007)

Copper (Cu) electrodeposition on ruthenium (Ru) oxides was studied due to important implications in semiconductor industry. Ruthenium, proposed as the copper diffusion barrier/liner material, has higher oxygen affinity to form different oxides. Three different oxides (the native oxide, reversible oxide, and irreversible oxide) were studied. Native oxide can be formed on exposing Ru in atmosphere. The reversible and irreversible oxides can be formed by applying electrochemical potential. Investigation of Cu under potential deposition on these oxides indicates the similarity between native and reversible oxides by its nature of inhibiting Cu deposition. Irreversible oxide formed on Ru surface is rather conductive and interfacial binding between Cu and Ru is greatly enhanced. After deposition, bimetallic corrosion of Cu/Ru in different polyphenols was studied. Polyphenols are widely used as antioxidants in post chemical mechanical planarization (CMP). For this purpose, different trihydroxyl substituted benzenes were used as antioxidants. Ru, with its noble nature enhances bimetallic corrosion of Cu. Gallic acid (3,4,5 - trihydroxybenzoic acid) was chosen as model compound. A mechanism has been proposed and validity of the mechanism was checked with other antioxidants. Results show that understanding the chemical structure of antioxidants is necessary during its course of reaction with Cu.
Thawing of cryopreserved hematopoietic progenitor cells from apheresis with a new dry‐warming device (2012)

Progenitor cell viability and function are preserved with this dry-thawing system. The time to hematopoietic engraftment of patients after transplantation is comparable to those infused with progenitor cells thawed with the water bath technique. Thawing cell products without the use of water and in a dry environment might favor the use of this dry method.
Untersuchungen zur Spektralanalyse hochlegierter Stähle (1961)

Untersuchungen über Anregungsbedingungen bei hochlegierten Stählen mit dem Funkenerzeuger FES 70 der Firma RSV in Verbindung mit einem Gitterspektrometer der Firma Ernst Leitz. Instabilität in der Nähe des kritischen Dämpfungswiderstandes. Die Eignung des Nullstrahls für die Spektralanalyse hochlegierter Stähle. Abfunkkurven. Einflüsse dritter Partner. Probennahme. Statistische Betrachtungen.
Adenosine receptor‐mediated contraction and relaxation of guinea‐pig isolated tracheal smooth muscle: effects of adenosine antagonists (1988)

1. The effects of several adenosine analogues and antagonists on guinea-pig isolated trachea have been examined. 2. 5'-N-ethylcarboxamidoadenosine (NECA), 5'-N-methylcarboxamidoadenosine (MECA) and adenosine (in the presence and absence of dipyridamole) elicited concentration-dependent tracheal relaxation. 3. The R(-)- and S(+)-enantiomers of N6-(2-phenylisopropyl)adenosine (R-PIA and S-PIA respectively), N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (CADO) caused contractions at low concentrations (0.05-2.0 microM), whereas at higher concentrations, relaxation resulted. 4. For tracheal relaxation, the adenosine analogues exhibited the following rank order of potency: NECA greater than CADO greater than R-PIA = MECA greater than S-PIA greater than adenosine. The rank order of potency for inducing contractions was R-PIA greater than CHA greater than CADO greater than S-PIA. These data suggest that relaxation is mediated by adenosine A2-receptors, whereas contraction is the result of activation of A1-receptors. 5. 8-Phenyltheophylline (8-PT), aminophylline, the triazoloquinazoline CGS 15943A and NPC205 (1,3-di-n-propyl-8-(4-hydroxyphenyl)xanthine) each inhibited the R-PIA-induced contractile response, whereas enprofylline was without effect. NPC205, aminophylline and 8-PT were competitive antagonists, but CGS15943A was non-competitive. 6. That the most potent antagonist was the A1-selective agent, NPC205 (pA2 = 7.80), further suggests that the contraction is mediated by A1-receptors. Moreover, NPC205 was 13 times more potent as an antagonist of R-PIA-induced contractions (A1) than of NECA-induced relaxations (A2). 7. The antagonists were also found to relax the trachea by an unknown mechanism. That enprofylline did not antagonize the R-PIA-induced contractions, but was 3-4 times more potent a tracheal relaxant than aminophylline, further suggests that a direct effect on airway smooth muscle, rather than antagonism of endogenous adenosine, is more relevant to the bronchodilator effect of alkylxanthines in the treatment of asthma.
Structure and Function of the Virulence-Associated High-Temperature Requirement A of <i>Mycobacterium tuberculosis</i> (2008)

The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis ( Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 A resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb.
1.5–1.6 µm Wavelength (100) GalnAsP/InP DH Lasers (1980)

Long wavelength (100) GalnAsP/InP DH lasers in the range of 1.45–1.65 µm were obtained by two-phase solution technique using an “anti-meltback” layer which consists of a quaternary crystal and was attached on the active layer. Low normalized threshold current density J th / d of 5–6 KA/cm 2 /µm was obtained. The threshold current density less than 2 KA/cm 2 was obtained. The temperature dependence of lasing wavelength was about 5 Å/deg. at λ=1.55 µm. The spontaneous spectral width of 1.55 µm laser was 1400 Å at room temperature. Lasing thresholds of these laser diodes increased rapidly with the temperature at around 250 K.
Towards quantitative metagenomics of wild viruses and other ultra‐low concentration DNA samples: a rigorous assessment and optimization of the linker amplification method (2012)

Metagenomics generates and tests hypotheses about dynamics and mechanistic drivers in wild populations, yet commonly suffers from insufficient (< 1 ng) starting genomic material for sequencing. Current solutions for amplifying sufficient DNA for metagenomics analyses include linear amplification for deep sequencing (LADS), which requires more DNA than is normally available, linker-amplified shotgun libraries (LASLs), which is prohibitively low throughput, and whole-genome amplification, which is significantly biased and thus non-quantitative. Here, we adapt the LASL approach to next generation sequencing by offering an alternate polymerase for challenging samples, developing a more efficient sizing step, integrating a 'reconditioning PCR' step to increase yield and minimize late-cycle PCR artefacts, and empirically documenting the quantitative capability of the optimized method with both laboratory isolate and wild community viral DNA. Our optimized linker amplification method requires as little as 1 pg of DNA and is the most precise and accurate available, with G + C content amplification biases less than 1.5-fold, even for complex samples as diverse as a wild virus community. While optimized here for 454 sequencing, this linker amplification method can be used to prepare metagenomics libraries for sequencing with next-generation platforms, including Illumina and Ion Torrent, the first of which we tested and present data for here.
Modulation of genomic expression in the central nervous system (1997)

Doctorat en sciences médicales
A novel glutamine–RNA interaction identified by screening libraries in mammalian cells (1998)

The arginine-rich motif provides a versatile framework for RNA recognition in which few amino acids other than arginine are needed to mediate specific binding. Using a mammalian screening system based on transcriptional activation by HIV Tat, we identified novel arginine-rich peptides from combinatorial libraries that bind tightly to the Rev response element of HIV. Remarkably, a single glutamine, but not asparagine, within a stretch of polyarginine can mediate high-affinity binding. These results, together with the structure of a Rev peptide-Rev response element complex, suggest that the carboxamide groups of glutamine or asparagine are well-suited to hydrogen bond to G-A base pairs and begin to establish an RNA recognition code for the arginine-rich motif. The screening approach may provide a relatively general method for screening expression libraries in mammalian cells.
Development and Validation of a Practical Lower-Dose-Simulation Tool for Optimizing Computed Tomography Scan Protocols (2012)

An accurate technique for simulating lower-dose CT images was developed and validated, which can be used to retrospectively optimize CT protocols.
Enzyme Active in Hot Organic Media (1984)

RETURN TO ISSUEPREVNewsNEXTEnzyme Active in Hot Organic MediaRON DAGANIView Author Information WashingtonCite this: Chem. Eng. News 1984, 62, 27, 23Publication Date (Print):July 2, 1984Publication History Published online7 November 2010Published inissue 2 July 1984https://pubs.acs.org/doi/10.1021/cen-v062n027.p023https://doi.org/10.1021/cen-v062n027.p023newsACS PublicationsCopyright © 1984 American Chemical SocietyArticle Views9Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Organic reactions,Peptides and proteins Get e-Alerts
Tentative Classification of Diesel Fuel Oils (1954)

This Tentative Classification has been approved by the sponsoring committee and accepted by the Society in accordance with established procedures, for use pending adoption as standard. Suggestions for revisions should be addressed to the Society at 1916 Race St., Philadelphia 3, Pa.
RNA Encoding the MPT83 Antigen Induces Protective Immune Responses against<i>Mycobacterium tuberculosis</i>Infection (2004)

We have previously demonstrated that vaccination of mice with plasmid DNA vectors expressing immunodominant mycobacterial genes induced cellular immune responses and significant protection against challenge with Mycobacterium tuberculosis. We demonstrate here, using in vitro-synthesized RNA, that vaccination with DNA or RNA constructs expressing the M. tuberculosis MPT83 antigen are capable of inducing specific humoral and T-cell immune responses and confer modest but significant protection against M. tuberculosis challenge in mice. This is the first report of protective immunity conferred against intracellular bacteria by an RNA vaccine. This novel approach avoids some of the drawbacks of DNA vaccines and illustrates the potential for developing new antimycobacterial immunization strategies.
On-Chip Transduction of Nucleic Acid Hybridization Using Spatial Profiles of Immobilized Quantum Dots and Fluorescence Resonance Energy Transfer (2011)

The glass surface of a glass-polydimethylsiloxane (PDMS) microfluidic channel was modified to develop a solid-phase assay for quantitative determination of nucleic acids. Electroosmotic flow (EOF) within channels was used to deliver and immobilize semiconductor quantum dots (QDs), and electrophoresis was used to decorate the QDs with oligonucleotide probe sequences. These processes took only minutes to complete. The QDs served as energy donors in fluorescence resonance energy transfer (FRET) for transduction of nucleic acid hybridization. Electrokinetic injection of fluorescent dye (Cy3) labeled oligonucleotide target into a microfluidic channel and subsequent hybridization (within minutes) provided the proximity for FRET, with emission from Cy3 being the analytical signal. The quantification of target concentration was achieved by measurement of the spatial length of coverage by target along a channel. Detection of femtomole quantities of target was possible with a dynamic range spanning an order of magnitude. The assay provided excellent resistance to nonspecific interactions of DNA. Further selectivity of the assay was achieved using 20% formamide, which allowed discrimination between a fully complementary target and a 3 base pair mismatch target at a contrast ratio of 4:1.
UF Business Library: Business Articles: Articles (2008)

Business & Economics article and journal databases and links to online business news sources
Acute susceptibility of aged mice to infection with Candida albicans (1999)

The effect of aging on host resistance to systemic candidosis was assessed by monitoring the course of infection in 16-month-old CBA/CaH mice (aged non-immune) and in a comparable group that had been infected with a sublethal dose of Candida albicans at 6 weeks of age (aged immune). Aged non-immune mice showed rapid progression of the disease, with a marked increase in the number of mycelia in the brain and kidney, and early morbidity. Foci of myocardial necrosis were evident, but inflammatory cells were sparse. The histological picture in the aged immune mice was similar to that in the aged non-immune group, although fewer mycelial aggregates were seen. Both groups of aged mice showed a significantly lower fungal burden in the brain on day 1 of infection, but on day 4, colony counts increased significantly in the aged non-immune mice. Comparison of cytokine gene expression in the infected brains showed that the relative amount of interferon-gamma and tumour necrosis factor-alpha cDNA were similar in all three groups. Interleukin-6 was elevated in both infected non-immune and uninfected aged mice. Aged immune mice showed no morbidity after challenge, and both colonisation and tissue damage were reduced in comparison with the aged non-immune animals.
Biosynthesis of 5‐Aminopentanoic Acid and 2‐Piperidone from Cadaverine and 1‐Piperideine in Mouse (1984)

1-Piperideine, 5-aminopentanoic acid, and its lactam, 2-piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both metabolites were also found when the cadaverine metabolite 1-piperideine was incubated with the preparation which suggested that 1-piperideine is an intermediate in the formation of 5-aminopentanoic acid and 2-piperidone. Identification of the metabolites was based on gas chromatography-mass spectrometric analysis in comparison to authentic standards. Mouse brain homogenates converted 1-piperideine to 5-aminopentanoic acid. The results suggest that the metabolic fate of cadaverine may provide precursors of pharmacologically active analogues of GABA.
Noise Reduction of Video Sequences Using Detection Method (2009)

A noise reduction method of video sequences using moving and noise detection has been proposed in this paper. The proposed filtering method firstly divides pixels into stationary and large moving deviation. Afterwards, by a further detection, we divide the pixels of large moving deviation into noise causing and moving causing so as to use different filtering algorithm to obtain the desired effect. Experimental results have shown that, compared with the conventional adaptive temporal video denoising method, the proposed method protects the edge and detail part in the image more effective, and also overcomes the trailing phenomenon well. Meanwhile, the proposed method has a small computation load, so can be realized and combined with other spatial noise reduction algorithm easily. In a way, it has a certain application value.
Cyclin-Dependent Kinase Inhibition by the KLF6 Tumor Suppressor Protein through Interaction with Cyclin D1 (2004)

Kruppel-like factor 6 (KLF6) is a tumor suppressor gene inactivated in prostate and colon cancers, as well as in astrocytic gliomas. Here, we establish that KLF6 mediates growth inhibition through an interaction with cyclin D1, leading to reduced phosphorylation of the retinoblastoma protein (Rb) at Ser(795). Furthermore, introduction of KLF6 disrupts cyclin D1-cyclin-dependent kinase (cdk) 4 complexes and forces the redistribution of p21(Cip/Kip) onto cdk2, which promotes G(1) cell cycle arrest. Our data suggest that KLF6 converges with the Rb pathway to inhibit cyclin D1/cdk4 activity, resulting in growth suppression.
Solutions for DVB-T Systems (1999)

The digitisation of terrestrial transmission has arrived. Throughout the world pilot schemes and commercial preparations have started. Digital transmission enables many more programmes to be broadcasted in the same bandwidth, so that there can be a substantial increase in revenues for network providers and a considerable reduction in costs for existing service providers. In addition the prospect of digital transmission brings crystal clear pictures and sound to the consumer. As an added bonus, the digital era opens the gateway to compelling additional services such as electronic programme guides, pay TV, data broadcasting (e.g. transportation of high-speed IP data) and enhanced broadcasting (e.g. home shopping, quiz). — This contribution addresses several key issues that play a key role when constructing digital terrestrial systems based on the DVB-T standard. Various solutions will be presented that enable broadcasters and network operators to achieve their business goals. The following topics will be addressed: • video encoding in conjunction with statistical multiplexing; • primary distribution; • remultiplexing; • splicing; • (joint) bit rate transcoding; • logo insertion; • network management; • SI (re-)generation and distribution; • conditional access and DVB simulcrypt; • enhanced and data broadcasting.