gebhart/patrepeval huggingface dataset:
A Phase I/II Study of Xcellerated T Cells™ after Autologous Peripheral Blood Stem Cell Transplantation in Patients with Multiple Myeloma. (2004)

Abstract Background: Previous studies have demonstrated a correlation between survival and lymphocyte recovery following autologous transplantation in subjects with multiple myeloma and other malignancies (Porrata et al., Blood 2001). We initiated a trial in the transplant setting to evaluate the activity of T cells activated and expanded ex vivo with the Xcellerate™ Process, which uses anti-CD3 and anti-CD28 antibody-coated magnetic beads (Xcyte™ -Dynabeads®). Methods: Following induction therapy, patients underwent leukapheresis to collect peripheral blood mononuclear cells for the Xcellerate Process. Patients then underwent stem cell mobilization and collection, followed by high dose melphalan (200 mg/m2). Three days following peripheral blood stem cell infusion, subjects received 50–100 x 109 Xcellerated T Cells. Results: 36 subjects were treated. The median last f/u visit is 180 days post-transplant (range 90–450). A WaveBioreactor-based Xcellerate III Process, which was instituted in the last 18 subjects, resulted in 249 ± 90 fold (mean ± SD) T cell expansion. There were 93.6 ± 0.8 x 109 cells infused, which were 97.6 + 4.0% T cells. There were no Grade 3 or 4 acute infusional toxicities. Days of neutropenia and thrombocytopenia were 5 (3–43) and 4.5 (0–128) respectively [median (range)]. There were a median of 2 (range 0–14) units of packed red blood cell transfusions in 18/31 (58%) of subjects and a median of 0 (range 0–22) platelet transfusions in 15/31 (48%) of subjects. There were serious or Grade 3 infections in 5/29 (17%) of subjects, and mucositis in 5/29 (17%) of subjects (all ≤ Grade 2). Median days of hospitalization were 16 (range 10–70). Lymphocyte recovery was rapid, with counts reaching > 500/mm3 generally within 1–2 days following T cell infusion. Historically, lymphocyte recovery to > 500/mm3 usually does not occur for 3 or more weeks post-transplant. The rapid lymphocyte recovery included both CD4+ and CD8+ T cells. The mean (± SEM) CD4+ T cell count at 90 days post-transplant was 1,210 ± 80/mm3, significantly higher than that for historical controls receiving the same treatment regimen without Xcellerated T Cells (198 ± 72). The T cell receptor repertoire measured 25 days after the Xcellerated T Cell infusion demonstrated a normal pattern (n = 4/5). This is in contrast to the severe skewing of T cell receptor diversity observed in myeloma subjects following standard autologous stem cell transplantation (Mariani et al, BJH 2001). In 35 evaluable patients, preliminary results demonstrated 6% CRs, 46% VGPRs, 34% PRs, and 11% with PD, using the M-protein at diagnosis as reference. There have been no reported deaths to date. Conclusions: In multiple myeloma subjects, administration of Xcellerated T Cells following high-dose chemotherapy and autologous stem cell transplantation leads to rapid lymphocyte recovery and appears to restore a normal T cell receptor repertoire. The majority of subjects achieve clinical responses in the autologous transplant setting.
Application of nanojunction-based RRAM to reconfigurable IC (2008)

A novel reconfigurable architecture, rFPGA, is developed by utilising high-density resistive memory (RRAM) circuits as FPGA components. Different from the existing CMOS-nano hybrid FPGAs that use crossbars, the rFPGA mainly consists of 1T1R RRAM structures (one CMOS transistor is integrated with a two-terminal resistive nanojunction) that can be fabricated using an efficient CMOS-compatible process. These 1T1R structures can significantly improve the FPGA memory and routing circuits, and enable the rFPGA to achieve at least a 2× density enhancement along with a 10% reduction of delay and power, compared with the corresponding CMOS FPGA.
Fast Inhibition Alters First Spike Timing in Auditory Brainstem Neurons (2004)

Within the first processing site of the central auditory pathway, inhibitory neurons (D stellate cells) broadly tuned to tonal frequency project on narrowly tuned, excitatory output neurons (T stellate cells). The latter is thought to provide a topographic representation of sound spectrum, whereas the former is thought to provide lateral inhibition that improves spectral contrast, particularly in noise. In response to pure tones, the overall discharge rate in T stellate cells is unlikely to be suppressed dramatically by D stellate cells because they respond primarily to stimulus onset and provide fast, short-duration inhibition. In vivo intracellular recordings from the ventral cochlear nucleus (VCN) showed that, when tones were presented above or below the characteristic frequency (CF) of a T stellate neuron, they were inhibited during depolarization. This resulted in a delay in the initial action potential produced by T stellate cells. This ability of fast inhibition to alter the first spike timing of a T stellate neuron was confirmed by electrically activating the D stellate cell pathway that arises in the contralateral cochlear nucleus. Delay was also induced when two tones were presented: one at CF and one outside the frequency response area of the T stellate neuron. These findings suggest that the traditional view of lateral inhibition within the VCN should incorporate delay as one of its principle outcomes.
Human T-cell lymphoblastic lymphoma expressing the T-cell receptor gamma/delta established in immune-deficient (bg/nu/xid) mice. (1993)

A small subgroup of human CD3-positive T-cell lymphoblastic lymphoma (T-LL) has been recently identified to express the T-cell receptor (TCR) gamma/delta heterodimer. Moreover peculiar clinical and histologic patterns of spleen and liver involvement have been associated with the TCR gamma/delta phenotype of tumor cells. In this paper we describe a human T-LL cell line (LL-DP) established in beige-nude-xid (BNX) mice, that by immunophenotype, molecular, and karyotype analyses, maintained most of the features of the patient. After serial transplants in BNX mice, LL-DP acquired quite a stable phenotype, producing a visible tumor in about 5 weeks in all the intravenously injected animals. The minimum number of transplanted cells that produce a tumor in all mice is 1 x 10(6). BNX mice bearing LL-DP lymphoma cells presented marked abdominal distension and splenomegaly. Diffuse lymphadenopathy with large tumor deposits in various lymph nodes that produce architectural effacement with a diffuse growth pattern was documented. The bone marrow was completely replaced, and spleen, liver, and kidneys were involved. Invasion of the central nervous system was leptomeningeal and perivascular. Overall this model might be useful for understanding mechanisms supporting lymphoma growth and progression as well as for testing new therapeutic strategies.
Developing spatially-aware content management systems for dynamic, location-specific information in mobile environments (2005)

Current location-aware information systems lack an effective method of maintaining and updating dynamic, location-specific content. We have developed a design for representing location-specific content that balances flexibility and comprehensibility. We have developed a web-based content management system that implements this design. The system provides an easy-to-use interface to tie any form of media-such as text, pictures, audio, or video-to a location.This work is directly applicable to various forms of location-aware systems, such as tourist information, campus guides, and vehicular on-board navigation. Our work enhances these systems by providing a greater range of content and a more dynamic information base than is currently available in extant systems. We describe how our design allows end-users to easily contribute spatial data to these systems, while simultaneously providing structure to their contributions. Mobile users, utilizing WLAN hotspots in common, real-world environments, can greatly benefit from and easily contribute to location-aware information systems driven by spatially-aware content management systems.
Optimal Levels of Arginine in Maintenance Intravenous Hyperalimentation (1984)

The optimal levels of arginine (Arg) for growth and immunity were studied in mildly depleted, noninjured rats maintained on intravenous hyperalimentation. Three groups of S-D rats (eight/group, weighing 275-300 g) underwent catheter insertion, 1 day of fasting, and then 7 days of intravenous hyperalimentation consisting of 20% dextrose, adequate minerals and vitamins, and three amino acid regimens: (1) FreAmine II (1.55 g Arg/liter); (2) FreAmine III (4.05 g Arg/liter); (3) experimental (7.5 g Arg/liter). The increase in arginine levels was achieved by lowering the glycine levels. There were no differences among the groups in terms of body weight gain (6.9 vs 8.3 vs 10.0 g) or in cumulative N balance (574 vs 660 vs 642 mg). Liver, spleen, and adrenal weights did not differ. Thymus weight was greater in groups B and C: (A) 345 +/- 27 mg vs (B) 445 +/- 34 mg, p less than 0.05, vs (C) 438 +/- 26 mg, p less than 0.05) as were the total number of lymphocytes/thymus (X 10(-9) (A) 0.93 +/- 0.12 vs (B) 1.37 +/- 0.18, p less than 0.05, vs (C) 1.46 +/- 0.15, p less than 0.05). Mitogen-induced thymocyte blastogenesis (cpm) was greatest in group C in response to phytohemagglutinin: (A) 9.558 +/- 3,799 vs (B) 20,088 +/- 5,890, NS, vs (C) 37,234 +/- 6,209, p less than 0.01 vs A and p less than 0.05 vs B) and Concanavalin A: (A) 71,035 +/- 15,228 vs (B) 111,734 +/- 15,021, NS, vs (C) 172,967 +/- 19,861, p less than 0.01 vs A and p less than 0.05 vs B). In the intravenous hyperalimentation-maintained noninjured rat ARG concentrations more than 1.55 g/liter do not enhance N retention or growth. Larger doses of ARG have strong thymic immunostimulatory effects without any toxicity or growth reduction.
Impact of Nodal Metastases on Prognosis in Patients With Well-Differentiated Thyroid Cancer (2002)

When treated with total thyroidectomy and routine postoperative iodine 131 ablation, patients with well-differentiated thyroid carcinoma who present with neck node metastases outside the central compartment of the neck have an approximately 6-fold risk of developing recurrences, most of which occur in the neck.
Synthetic Applications of the β-Lithiation of β-Aryl Secondary Amides:  Diastereoselective and Enantioselective Substitutions (1996)

The sequence of beta-lithiation and electrophilic substitution of beta-aryl secondary amides is reported. The lithiations occur regioselectively at the beta-position, and the resulting lithiated intermediates can be reacted with a wide range of electrophiles to give substituted products. Reactions of beta-lithiated amides bearing an alpha-substituent provide substituted products with high diastereoselectivity. Electrophilic substitutions of beta-lithiated N-methylamides in the presence of the chiral diamine (-)-sparteine provide highly enantioenriched products. The methodology is used to synthesize enantioenriched beta-aryl beta-substituted amides, acids, and lactones.
RESPARC: A Reconfigurable and Energy-Efficient Architecture with Memristive Crossbars for Deep Spiking Neural Networks (2017)

Neuromorphic computing using post-CMOS technologies is gaining immense popularity due to its promising abilities to address the memory and power bottlenecks in von-Neumann computing systems. In this paper, we propose RESPARC - a reconfigurable and energy efficient architecture built-on Memristive Crossbar Arrays (MCA) for deep Spiking Neural Networks (SNNs). Prior works were primarily focused on device and circuit implementations of SNNs on crossbars. RESPARC advances this by proposing a complete system for SNN acceleration and its subsequent analysis. RESPARC utilizes the energy-efficiency of MCAs for inner-product computation and realizes a hierarchical reconfigurable design to incorporate the data-flow patterns in an SNN in a scalable fashion. We evaluate the proposed architecture on different SNNs ranging in complexity from 2k-230k neurons and 1.2M-5.5M synapses. Simulation results on these networks show that compared to the baseline digital CMOS architecture, RESPARC achieves 500X (15X) efficiency in energy benefits at 300X (60X) higher throughput for multi-layer perceptrons (deep convolutional networks). Furthermore, RESPARC is a technology-aware architecture that maps a given SNN topology to the most optimized MCA size for the given crossbar technology.
Sensor fusion method using GPS/IMU data for fast UAV surveillance video frame registration (2009)

This paper proposes an innovative framework for fast image registration of UAV surveillance video frames by fusing the data from a GPS receiver high-frequency IMU sensor (Piccolo autopilot) and a feature-domain registration method through a non-linear filter. The high-frequency imprecise data from the Piccolo autopilot is refined by the low-frequency precise data from our feature-domain based random M least squares (RMLS) method. The projective transformation model is chosen to achieve high precision. The state and measurement models are non-linear to approximate the real-world imaging dynamics. A periodic hybrid particle filter (PHPF), composed of extended Kalman filter (EKF) and unscented Kalman filter (UKF), is proposed to minimize running time while maintaining accuracy. Both the efficiency and effectiveness of the proposed algorithm will be evaluated through our experiments.
Two-dimensional conductometric detection in ion chromatography. Postsuppressor conversion of eluite acids to a salt (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-dimensional conductometric detection in ion chromatography. Postsuppressor conversion of eluite acids to a saltIngemar. Berglund and Purnendu K. DasguptaCite this: Anal. Chem. 1992, 64, 23, 3007–3012Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ac00047a023https://doi.org/10.1021/ac00047a023research-articleACS PublicationsRequest reuse permissionsArticle Views76Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Down at the Court House: A Photographic Essay (1980)

Florida's court houses are much like those found elsewhere throughout the United States.They are halls of justice, meeting and bargaining places, political headquarters, centers where human events take place officially.
DSA‐Mesh: a distributed security architecture for wireless mesh networks (2010)

Abstract Wireless Mesh Networks (WMNs) have emerged recently as a technology for next‐generation wireless networking. They consist of mesh routers and clients, where mesh routers are almost static and form the backbone of WMNs. WMNs provide network access for both mesh and conventional clients. In this paper, we propose DSA‐Mesh, a fully distributed security architecture that provides access control for mesh routers as well as a key distribution scheme that supports layer‐2 encryption to ensure security and data confidentiality of all communications that occur in the backbone of the WMN. DSA‐Mesh exploits the routing capabilities of mesh routers: after connecting to the access network as generic wireless clients, new mesh routers authenticate to a key management service (consisting of several servers) implemented using threshold cryptography, and obtain a temporary key that is used both to prove their credentials to neighbor nodes and to encrypt all the traffic transmitted on wireless backbone links. A key feature in the design of DSA‐Mesh is its independence from the underlying wireless technology used by network nodes to form the backbone. Furthermore, DSA‐Mesh enables seamless mobility of mesh routers. Since it is completely distributed, DSA‐Mesh permits to deploy automatically and incrementally large WMNs, while increasing, at the same time, the robustness of the system by eliminating the single point of failure typical of centralized architectures. DSA‐Mesh has been implemented in Network Simulator, and extensive simulations have been performed in large‐scale network scenarios, comparing it to a static key approach and to a centralized architecture where a single key server is deployed. Numerical results show that our proposed architecture considerably increases the WMN security and reliability, with a negligible impact on the network performance, thus representing an effective solution for wireless mesh networking. Copyright © 2010 John Wiley & Sons, Ltd.
Incidence and Treatment of Complications of Bacillus Calmette-Guerin Intravesical Therapy in Superficial Bladder Cancer (1992)

Intravesical therapy with bacillus Calmette-Guerin (BCG) has proved to be more effective in the prophylaxis and treatment of superficial bladder tumors and carcinoma in situ than most chemotherapeutic agents. Compared to intravesical chemotherapy, instillations with BCG provoke more local and systemic reactions. In addition to the commonly induced granulomatous inflammatory changes in the bladder, which produce irritative symptoms, this therapy may cause systemic side effects varying from mild malaise and fever to, in rare instances, life-threatening or fatal sepsis. We report the incidence and varieties of toxicities in 2,602 patients treated with intravesical BCG. Side effects are classified according to local and systemic toxicity. Treatment options vary according to the severity of toxicity from delaying or withholding instillations to treatment with antituberculous drugs for up to 6 months. In general, 95% of the patients have no serious side effects. Recognition of risk factors, particularly traumatic catheterization or concurrent cystitis, that result in systemic BCG absorption, as well as the prompt and appropriate treatment of early side effects should significantly decrease the incidence of severe toxicity.
The EC Domains of Human Fibrinogen420Contain Calcium Binding Sites But Lack Polymerization Pockets (1998)

Abstract The extended  (E) isoform unique to Fibrinogen420 (Fib420) is distinguished from the conventional  chain of Fibrinogen340 by the presence of an additional 236-residue carboxyl terminus globular domain (EC). A recombinant form of EC (rEC), having a predicted mass of 27,653 Daltons, was expressed in yeast (Pichia pastoris) and purified by anion exchange column chromatography. Purified rEC appears to be predominantly intact, as judged by N-terminal sequence analysis, mass spectral analysis of the C-terminal cyanogen bromide (CNBr) fragment, and comparison of recognition by epitope-specific monoclonal antibodies. Carbohydrate determination, coupled with analysis of CNBr digestion fragments, confirms N-linked glycosylation at Asn667, the site at which sugar is attached in E. Analysis of CNBr digestion fragments confirms that two disulfide bridges exist at cysteine pairs E613/644 and E780/793. In the presence of 5 mmol/L EDTA, rEC is highly susceptible to plasmic degradation, but Ca2+ (5 mmol/L) renders rEC resistant. No protective effect from plasmic degradation was conferred to rEC by the peptides GPRPamide or GHRP, nor did rEC bind to a GPR peptide column. These results suggest that the EC domain contains a calcium-binding site, but lacks a polymerization pocket. By analogy with the site elucidated in the γC domain, we predict that the EC calcium binding site involves residues E772-778: DADQWEE.
Mark Yourself: Road Marking Segmentation via Weakly-Supervised Annotations from Multimodal Data (2018)

This paper presents a weakly-supervised learning system for real-time road marking detection using images of complex urban environments obtained from a monocular camera. We avoid expensive manual labelling by exploiting additional sensor modalities to generate large quantities of annotated images in a weakly-supervised way, which are then used to train a deep semantic segmentation network. At run time, the road markings in the scene are detected in real time in a variety of traffic situations and under different lighting and weather conditions without relying on any preprocessing steps or predefined models. We achieve reliable qualitative performance on the Oxford RobotCar dataset, and demonstrate quantitatively on the CamVid dataset that exploiting these annotations significantly reduces the required labelling effort and improves performance.
On the Design and the Implementation of Secure Xenix Workstations (1986)

Secure Xenix * is an experimental system designed to run on IBM PC/AT workstations. Like Xenix, it is a Unix implementation on the PC/AT workstation; unlike Xenix, it eliminates the Unix security deficiencies and it enhances security policies. In this paper, we present the design features of Secure Xenix, their integration within Xenix, and some of the lessons learned from this experiment to date. In addition, we address some of the problems specific to workstations in the security management area. The major design differences between Secure Xenix and other experiments with Unix security enhancements, such as LINUS IV, are also presented. In a companion paper, we present the important problems that arise in the testing of Secure Xenix and their solutions.
[Expression and clinical significance of chemokine CXCL10 and its receptor CXCR3 in hepatocellular carcinoma]. (2019)

Expression of CXCL10 was up-regulated in HCC tissues, expression of CXCR3 was down-regulated in HBV-related HCC tissues, and the higher expression of both genes was correlated with better overall survival in HCC patients.
Application of photodecomposable base concept to two-component deep-UV chemically amplified resists (1996)

The use of photodecomposable bases (PDB) offers distinct benefits to the general lithographic performance, and in particular, to the stability of the latent image in positive tone chemically amplified deep UV resists (CAR). The PDB concept utilizes radiation sensitive basic compounds, such as triphenylsulfonium hydroxide (TPSOH), which are coformulated as additives to the resist formulation. In the exposed resist sectors the PDB is decomposed into neutral fragments, which do not interfere with the simultaneously produced acid from the photolyzed photoacid generator (PAG). In the unexposed regions the PDB remains active and effectively neutralizes acid molecules diffusing into these areas. The successful integration of the PDB concept into acetal-based three component systems has been described previously. Its usefulness for standard two component materials, consisting of a polymer partly reacted with acid-labile protective groups, such s t-BOC or acteal/ketal protected ploy-4-hydroxystyrene (PHS), and a PAG is investigated in this paper. The effects of the PDB on the latent image stability, and additional resist properties, such as transparency, sensitivity, contrast, standing waves, etc. are discussed in detail. Finally, a new high performance deep UV CAR material incorporating the PDB concept is presented.