gebhart/patrepeval huggingface dataset:
Extracellular deposition of eosinophil and neutrophil granule proteins in the IgE-mediated cutaneous late phase reaction. (1990)

Intradermal injection of allergens in sensitive subjects produces an IgE-dependent prolonged inflammatory reaction, the late phase reaction (LPR). Histologically, eosinophils are present in the LPR but are not as numerous as neutrophils or mononuclear cells. We determined whether extracellular deposition of eosinophil and neutrophil granule proteins occurs in the LPR by immunofluorescent localization of eosinophil granule major basic protein (MBP), eosinophil-derived neurotoxin (EDN), and neutrophil elastase. Before intradermal challenge, eosinophils and neutrophils were present only in blood vessels, and MBP, EDN, and elastase were localized to cells. At 15 minutes, small amounts of MBP, EDN and elastase were found outside of cells in focal areas. By 1 to 3 hours, MBP, EDN and elastase were extensively deposited throughout the dermis in a granular and diffuse manner; these deposits persisted up to 56 hours. Both actively and passively sensitized subjects showed similar MBP and elastase deposition. Skin sites passively sensitized by sera depleted of IgE showed essentially no MBP or elastase deposition. Electron microscopy showed degenerating eosinophils and free eosinophil granules in the dermis. Mast cell numbers diminished during the LPR when extracellular eosinophil and neutrophil granule protein deposition was maximal. These results demonstrate that striking dermal eosinophil and neutrophil granule protein deposits are prominent features of the cutaneous LPR, are IgE-dependent and precede the maximal clinical expression of the LPR. The possible significance of these findings in the pathophysiology of the LPR is discussed.
SAINT-Simulation Assistant for Analog Simulation (1998)

S.183-187
Myxobacteria: Cell Interactions, Genetics, and Development (1979)

Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly pathogenic HCoVs: severe acute respiratory syndrome coronavirus (SARS-CoV) and ...Read More
The binding of hepatitis A virus to cell surfaces shows evidence of positive co-operativity (1994)

Radio-iodinated hepatitis A virus binds to cultured mammalian cells in a saturable manner, with about 1.4 × 103 sites/cell and a S0.5 of about 1.4 × 10−11 M for FRhK-4 cells. This binding to FRhK-4 cells shows evidence of positive co-operativity, with a Hill coefficient of 2.1 (±0.1). This implies that the cellular receptor for the virus may have multiple binding sites and that the affinity of HAV for its receptor is increased if one of the binding sites is occupied by virus. Binding is completely blocked by two neutralising monoclonal antibodies, which also inhibit viral haemagglutination. A non-neutralising monoclonal antibody partially inhibits binding to FRhK-4 cells, but has no effect on haemagglutination.
Effect of trace mineral (mineral capsule) supplementation on nutrient utilization and rumen fermentation pattern in Sahiwal cows (Bos indicus). (2000)

The effect of supplementation of trace minerals, viz. Cu, Co, Mn and Zn on the utilization of nutrients and rumen fermentation pattern was studied in 16 Sahiwal cows. They were divided at random into 2 groups of 8 animals each. All the animals were individually offered green berseem and para grass (Brachiaria mutiea) ad lib. and standard concentrate mixture 3 kg/day. An additional amount of 1 kg crushed maize grain/day per animal was offered in both the groups. Group 1 was kept as control while group 2 was supplemented with Cu, Co, Mn and Zn in the form of gelatinised capsule (3.34,0.442, 7.62 and 125.73 mg/day) respectively. The experiment lasted for 120 days. Digestion trial was conducted on 8 cows of 4 in each group. The intake of DCP and TDN in groups 1 and 2 were 0.913, 0.903 and 6.33, 5.58 kg/day which were statistically nonsignificant (P<0.05). However, the intake of DM and DCP (kg/100 kg bwt) was significantly (P<0.05) higher in mineral supplemented group' as compared to control group. Similarly digestibilities of OM, NFE and hemicellulose were significantly higher in group 2 than that of group 1. The concentration of TCA ppt-N in SRL was also significantly higher (P<0.05) in group 2 as compared to group I, whereas NH3-N concentration was significantly (P<0.05) higher in group I than that in group 2, suggesting an enhanced activity ofNH3 utilization by rumen microbes. Mineral supplementation, however, had increased the blood sugar to almost double Le. from 32.90 to 65.53 mg/100ml, and TVF A concentration from 134 to 140 meq/litre. The other rumen parameters, viz. pH and NPN, total Nand TCA-ppt N were not affected. The Hb concentration was significantly higher in trace mineral supplemented group compared to control suggesting better utilization of related minerals and protein for the synthesis of Hb. It may be concluded that supplementation of Cu, Co, Mn and Zn at 1.75,0.058, 1 and 16.5ppm, respectively, in the ration of Sahiwal cows appears to be adequate for better nutrient utilization, rumen fermentation pattern and microbial activity in mature cows.
Hollow Rotating Detonation Combustor (2016)

A continuous, azimuthally rotating, detonation wave propagating between the confines of a narrow annulus has been the essence of the Rotating Detonation Combustor (RDC) mechanics, till date. This research, however, focuses on the incipient RDC concept that utilizes a hollow combustor for the sustained rotating detonation, instead of the conventional annular combustor. Hydrogen-Air operation is demonstrated in a hollow RDC (H-RDC). The concomitant detonation wave speeds are upwards of 90% of the ideal Chapman-Jouguet speed at rich conditions of operation. While the H-RDC is prone to two wave operation for all the air flow rates tested, highly rich conditions produce solely single wave operation. High-speed video imaging of the H-RDC exit highlights the presence of a complex detonation structure comprising a relatively faster detonation wave that moves along the combustor wall, and a sectoral region of intense combustion that rotates with the same angular velocity. The pressure profile of the operating points is analyzed to reveal three different waveform shapes which are further analyzed using ensemble averaging. A peculiar instability observed for select operating conditions is discussed.
The design framework of the civil court case management system in Thailand (2007)

This paper proposes a design framework of an IT development for the judiciary system in Thailand. The initial framework focuses on supporting the work flow of the Central Intellectual Property and International Trade Court (CIPITC). The research methodology includes an extensive survey on information technology adoption in judiciary system of other countries. The initial design is drawn based on two important concepts which are Case Management System (CMS) and Web Service (WS). Software and system architectures are presented. After the detailed design has been concluded, a part of the framework will be developed and evaluated.
Transparent cubic Fd3m mesoporous silica monoliths with highly controllable pore architectures (2005)

Ordered cubic Fd3m mesoporous silica monoliths (HOM-11) were fabricated by using lyotropic and microemulsion phases of block copolymers (EOm–POn–EOm) as templates. Aromatic and aliphatic hydrocarbon molecules were used in the formation of true microemulsion liquid crystal phases, in the expansion of pore sizes, and in the changes in the phase geometrical shape. Large cylinder-like pores in the range of 6–11 nm with uniform constrictions and bimodal mesopore sizes can be easily produced (within minutes) by adopting this simple and reproducible strategy. The degree of solubilization of the hydrocarbons crucially influenced the generation of the more open-pore systems with cylindrical cubic Fd3m channels. Our results also show that enlargement of pore sizes of cubic Fd3m monoliths was achieved with the use of a high concentration of copolymers in the composition phase domains, a high degree of swelling and a large size of PO–EO blocks (core–corona) of the copolymer templates. In addition, this synthetic approach is also efficient in designing cubic Fd3m silica monoliths with large-sized glass, thick-walled frameworks up to 30 nm thick and high mesopore/micropore volumes. Although XRD patterns show well-defined Bragg diffraction peaks indicative of highly ordered cubic Fd3m structures, TEM micrographs reveal that worm-like mesopore channels in large domains were observed with samples synthesized from copolymers with small EO–PO block ratios. This finding indicates that the molecular nature (i.e. the flexibility of the corona- and core-blocks) of the copolymer templates not only led to disordered pore channels but also reduced the ability to design more mesostructured phases.
What is the ensemble Kalman filter and how well does it work? (2006)

In this paper we described the ensemble Kalman filter algorithm. This approach to nonlinear Kalman filtering is a Monte Carlo procedure, which has been widely used in weather forecasting applications. Our goal was to apply the ensemble Kalman filter to representative examples to quantify the tradeoff between estimation accuracy and ensemble size. For all of the linear and nonlinear examples that we considered, the ensemble Kalman filter worked successfully once a threshold ensemble size was reached. In future work we will investigate the factors that determine this threshold value.
Automating transition from use-cases to class model (2004)

To identify objects from the requirements and to model the problem in classes are critical in object-oriented analysis and design (OOAD). Unfortunately, this is recognized as a hard task for most software engineers, because both domain experience and expertise are needed, since there is no crisp guideline. We present an approach with a set of artifacts and methodologies, and to automate the transition from requirement to detail design. Use cases are applied as the method to capture and record requirements. All the use cases are formalized by a use case template. A glossary that contains the domain vocabulary is used throughout the OOAD process to reduce the vagueness of natural language. Some language patterns are introduced to make the automatic processing of use cases possible. We apply robustness analysis to bridge the gap between a use case and its realization, i. e. between a use case and the corresponding collaboration diagram in UML. Some rules are summarized and adopted to automate the object/class identification and behavior distribution among the classes. The implementation of the tool is described.
Age-Dependent Associations Between Chronic Periodontitis/Edentulism and Risk of Coronary Heart Disease (2008)

Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.
Characterization of Multilayer Anti-Fog Coatings (2011)

Fog formation on transparent substrates constitutes a major challenge in several optical applications requiring excellent light transmission characteristics. Anti-fog coatings are hydrophilic, enabling water to spread uniformly on the surface rather than form dispersed droplets. Despite the development of several anti-fog coating strategies, the long-term stability, adherence to the underlying substrate, and resistance to cleaning procedures are not yet optimal. We report on a polymer-based anti-fog coating covalently grafted onto glass surfaces by means of a multistep process. Glass substrates were first activated by plasma functionalization to provide amino groups on the surface, resulting in the subsequent covalent bonding of the polymeric layers. The anti-fog coating was then created by the successive spin coating of (poly(ethylene-maleic anhydride) (PEMA) and poly(vinyl alcohol) (PVA) layers. PEMA acted as an interface by covalently reacting with both the glass surface amino functionalities and the PVA hydroxyl groups, while PVA added the necessary surface hydrophilicity to provide anti-fog properties. Each step of the procedure was monitored by XPS, which confirmed the successful grafting of the coating. Coating thickness was evaluated by profilometry, nanoindentation, and UV visible light transmission. The hydrophilic nature of the anti-fog coating was assessed by water contact angle (CA), and its anti-fog efficiency was determined visually and tested quantitatively for the first time using an ASTM standard protocol. Results show that the PEMA/PVA coating not only delayed the initial period required for fog formation but also decreased the rate of light transmission decay. Finally, following a 24 hour immersion in water, these PEMA/PVA coatings remained stable and preserved their anti-fog properties.
High-level synthesis assisted rapid prototyping for digital signal processing (2005)

The increasing needs of higher data rates associated with mobility constraints motivate the development of digital satellite news gathering (DSNG) and digital video broadcasting applications by satellite (DVB/spl I.bar/S). Error control codes like Reed-Solomon and Viterbi codes are widely used in these communication systems against channel noise. Traditional methods for rapid prototyping of hardware cores for this kind of applications are based on RTL specifications. However, they suffer from heavy limitations that prevent them from efficiently addressing both the algorithmic complexity and the high flexibility required by the various application profiles in fast implementation and prototyping issues. For this reasons, we propose to reduce hardware IP core development time by benefiting from the emerging high-level synthesis (HLS) tools in a platform-based approach dedicated to rapid prototyping. This technique has been successfully applied to the design of Reed-Solomon (RS) and Viterbi decoder IP cores for the DVB-DSNG standard and can be easily extended to many DSP dataflow applications.
Experimental Analysis of Plantar Fascia Mechanical Properties in Subjects with Foot Pathologies (2021)

Plantar Fascia (PF) is a fibrous tissue that plays a key role in supporting the foot arch; it can be affected by several pathologies that can alter foot biomechanics. The present study aims at investigating the mechanical behavior of PF and evaluating possible correlations between mechanical properties and specific pathologies, namely diabetes and plantar fibromatosis (Ledderhose syndrome). PF samples were obtained from 14 human subjects, including patients with Ledderhose syndrome, patients affected by diabetes and healthy subjects. Mechanical properties of PF tissues were evaluated on three samples from each subject, by cyclic uniaxial tensile tests up to 10% of maximum strain and stress relaxation tests for 300 s, in hydrated conditions at room temperature. In tensile tests, PF exhibits non-linear stress–strain behavior, with a higher elastic modulus (up to 25–30 MPa) in patients affected by Ledderhose syndrome and diabetes with respect to healthy subjects (elastic modulus 10 ÷ 14 MPa). Stress-relaxation tests show that PF of patients affected by Ledderhose syndrome and diabetes develop more intense viscous phenomena. The results presented in this work represent the first experimental data on the tensile mechanical propertied of PF in subjects with foot diseases and can provide an insight on foot biomechanics in pathological conditions.
N‐terminal methionine removal and methionine metabolism in <i>Saccharomyces cerevisiae</i> (2003)

Methionine aminopeptidase (MetAP) catalyzes removal of the initiator methionine from nascent polypeptides. In eukaryotes, there are two forms of MetAP, type 1 and type 2, whose combined activities are essential, but whose relative intracellular roles are unclear. Methionine metabolism is an important aspect of cellular physiology, involved in oxidative stress, methylation, and cell cycle. Due to the potential of MetAP activity to provide a methionine salvage pathway, we evaluated the relationship between methionine metabolism and MetAP activity in Saccharomyces cerevisiae. We provide the first demonstration that yeast MetAP1 plays a significant role in methionine metabolism, namely, preventing premature activation of MET genes through MetAP function in methionine salvage. Interestingly, in cells lacking MetAP1, excess methionine dramatically inhibits cell growth. Growth inhibition is independent of the ability of methionine to repress MET genes and does not result from inhibition of synthesis of another metabolite, rather it results from product inhibition of MetAP2. Inhibition by methionine is selective for MetAP2 over MetAP1. These results provide an explanation for the previously observed dominance of MetAP1 in terms of N-terminal processing and cell growth in yeast. Additionally, differential regulation of the two isoforms may be indicative of different intracellular roles for the two enzymes.
<title>Audit of a road bridge superstructure using ground penetrating radar</title> (2000)

This paper describes a new application of Ground Penetrating Radar (GPR) in non-destructively assessing the delivered quality of bridge superstructure beams. A case history is described where GPR was used to assess the quality of 180 prestressed concrete beams in relation to the requirements specified in the engineering design. The beams analyzed in this project represent a standard design used in Queensland where several large polystyrene blocks (called 'voids') are cast internally within the deck beams to reduce the mass of the beams. GPR was used effectively to determine the finished location of these voids within the beams and identify any defects associated with the movement of the voids during manufacture of the beams. It was concluded that at least 90% of the beams were out of tolerance due to significant void movement in a vertical direction and there were significant associated defects of air cavities within the concrete, thin top and bottom flanges and longitudinal soffit cracking. Predominantly the voids had moved downwards during the concrete placement process. The accuracy of the GPR survey was determined to be +/- 5 mm where good calibration was obtained and +/- 10 mm for the global set of results of 4860 measurement points.
A chorus section detection method for musical audio signals and its application to a music listening station (2006)

This paper describes a method for obtaining a list of repeated chorus ("hook") sections in compact-disc recordings of popular music. The detection of chorus sections is essential for the computational modeling of music understanding and is useful in various applications, such as automatic chorus-preview/search functions in music listening stations, music browsers, or music retrieval systems. Most previous methods detected as a chorus a repeated section of a given length and had difficulty identifying both ends of a chorus section and dealing with modulations (key changes). By analyzing relationships between various repeated sections, our method, called RefraiD, can detect all the chorus sections in a song and estimate both ends of each section. It can also detect modulated chorus sections by introducing a perceptually motivated acoustic feature and a similarity that enable detection of a repeated chorus section even after modulation. Experimental results with a popular music database showed that this method correctly detected the chorus sections in 80 of 100 songs. This paper also describes an application of our method, a new music-playback interface for trial listening called SmartMusicKIOSK , which enables a listener to directly jump to and listen to the chorus section while viewing a graphical overview of the entire song structure. The results of implementing this application have demonstrated its usefulness
Sn-Cu Solder Bump Formation from Acid Sulfate Baths Using Electroplating Method (2003)

The purpose of this investigation was to form Sn-Cu solder bumps for flip-chip bonding from acid sulfate bath (2M H2SO4+0.2M SnSO4+0.008 M CuSO4) containing N,N-bis(polyoxyethylene)octadecylamine (POOA-10) using electroplating method. Compact and relatively smooth Sn-Cu alloy electrodeposits were obtained from acid sulfate baths containing POOA-10. Cu contents in electrodeposits were approximately constant in the range of current densities from 1.0 to 7.0 A/dm2. The solidus temperature of Sn-Cu alloy electrodeposits was 227℃. Sn-Cu alloy bumps of straightwall and mushroom types with homogeneous composition were obtained from acid sulfate baths containing POOA-10 under galvanostatic condition.
Real-Time Diesel Particulate Measurement Using A Tapered Element Oscillating Microbalance (1982)

<div class="htmlview paragraph">A Tapered Element Oscillating Micro-balance (TEOM), consisting of a tapered tube fixed at the wide end with a filter element attached to the narrow end which is free to oscillate, can monitor diesel exhaust particulate by drawing a sample through the filter element. As particulate mass accumulates on the filter, a small change in the frequency of oscillation, directly related to mass, is detected in real-time. As described in this study TEOM sensitivity on the order of 5×10<sup>−8</sup> g-sec<sup>−1</sup> may be achieved over sample periods of 8-15 seconds. Two light duty diesel vehicles were tested using FTP-Bag III and NYCC driving schedules. For 29 vehicle tests, the mean ratio of total TEOM mass to simultaneously collected 47 mm filter samples was 0.96 (C.V. = 13%). Real-time TEOM data should prove valuable to particulate control technology efforts and environmental impact assessment.</div>
Automated Partitioning of Tonal Music (2000)

Most research related to automated analysis of music presupposes human partitioning of the input into segments corresponding to significant harmonic or melodic chunks. In this paper, we describe HarmAn, a system that partitions tonal music into harmonically significant segments corresponding to single chords and labels these segments with the proper chord labels. Segment labels are determined through template matching in the space of pitch class with conflict resolution between equally scoring templates resolved through simple preference roles. Our system’s results are compared with published results.
Characterization of Susceptibility and Resistance Responses to Potato Cyst Nematode (<i>Globodera</i> spp.) Infection of Tomato Lines in the Absence and Presence of the Broad-Spectrum Nematode Resistance <i>Hero</i> Gene (2005)

The tomato Hero A gene is the only member of a multigene family that confers a high level (>80%) of resistance to all the economically important pathotypes of potato cyst nematode (PCN) species Globodera rostochiensis and G. pallida. Although the resistance levels of transgenic tomato lines were similar to those of the tomato line LA1792 containing the introgressed Hero multigene family, transgenic potato plants expressing the tomato Hero A gene are not resistant to PCNs. Comparative microscopy studies of in vitro infected roots of PCN-susceptible tomato cv. Money Maker, the resistant breeding line LA1792, and transgenic line L10 with Ro1 pathotype have revealed no statistically significant difference in the number of juveniles invading roots. However, syncytia (specialized feeding cells) induced in LA1792 and L10 roots mostly were found to have degenerated a few days after their induction, and a few surviving syncytia were able to support only the development of males rather than females. Thus, the ratio between males and females was biased towards males on LA1792 and L10 roots. A series of changes occur in resistant plants leading to formation of a layer of necrotic cells separating the syncytium from stellar conductive tissues and this is followed by degradation of the syncytium. Although the Hero A gene is expressed in all tissues, including roots, stems, leaves, and flower buds, its expression is upregulated in roots in response to PCN infection. Moreover, the expression profiles of the Hero A correlates with the timing of death of the syncytium.