gebhart/patrepeval huggingface dataset:
Intestinal Absorption of Dipeptides and Corresponding Free Amino Acids in Hartnup Disease (1970)

Conference Abstract| July 01 1970 Intestinal Absorption of Dipeptides and Corresponding Free Amino Acids in Hartnup Disease A. M. Asatoor; A. M. Asatoor 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar B. Cheng; B. Cheng 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar K. D. G. Edwards; K. D. G. Edwards 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar A. F. Lant; A. F. Lant 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar D. M. Matthews; D. M. Matthews 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar M. D. Milne; M. D. Milne 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar F. Navab; F. Navab 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar A. J. Richards A. J. Richards 1Westminster Hospital and Medical School, London Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (1970) 39 (1): 1P. https://doi.org/10.1042/cs039001Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A. M. Asatoor, B. Cheng, K. D. G. Edwards, A. F. Lant, D. M. Matthews, M. D. Milne, F. Navab, A. J. Richards; Intestinal Absorption of Dipeptides and Corresponding Free Amino Acids in Hartnup Disease. Clin Sci 1 July 1970; 39 (1): 1P. doi: https://doi.org/10.1042/cs039001Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1970 The Biochemical Society and the Medical Research Society1970 Article PDF first page preview Close Modal You do not currently have access to this content.
Modular Synthesis of Heterocyclic Carbene Precursors (2006)

A series of N-heterocyclic carbene precursors, containing an imidazoline or tetrahydropyrimidine framework, were prepared from omega-chloroalkanoyl chlorides. The sequential attachment of nitrogen nucleophiles and subsequent ring closure gave, depending on the reagents used, either the desired dihydroimidazolium and tetrahydropyrimidinium salts or their parent heterocycles. In this latter case, the second substituent was introduced in an alkylation step. The preparation of carbene precursors bearing chiral or bulky substituents was acieved with comparable efficiency.
Capacitive Deionization of NaCl and NaNO3 Solutions with Carbon Aerogel Electrodes (1996)

A process for the capacitive deionization of water with a stack of carbon aerogel electrodes has been developed by Lawrence Livermore National Laboratory. Unlike ion exchange, one of the more conventional deionization processes, no chemicals are required for regeneration of the system. Electricity is used instead. Water with various anions and cations is pumped through the electrochemical cell. After polarization, ions are electrostatically removed from the water and held in the electric double layers formed at the surfaces of electrodes. The water leaving the cell is purified, as desired. The effects of cell voltage and cycling on the electrosorption capacities for NaCl and have been investigated and are reported here.
An Improved Biometrics-Based Remote User Authentication Scheme with User Anonymity (2013)

The authors review the biometrics-based user authentication scheme proposed by An in 2012. The authors show that there exist loopholes in the scheme which are detrimental for its security. Therefore the authors propose an improved scheme eradicating the flaws of An's scheme. Then a detailed security analysis of the proposed scheme is presented followed by its efficiency comparison. The proposed scheme not only withstands security problems found in An's scheme but also provides some extra features with mere addition of only two hash operations. The proposed scheme allows user to freely change his password and also provides user anonymity with untraceability.
Private API Access and Functional Mocking in Automated Unit Test Generation (2017)

Not all object oriented code is easily testable: Dependency objects might be difficult or even impossible to instantiate, and object-oriented encapsulation makes testing potentially simple code difficult if it cannot easily be accessed. When this happens, then developers can resort to mock objects that simulate the complex dependencies, or circumvent object-oriented encapsulation and access private APIs directly through the use of, for example, Java reflection. Can automated unit test generation benefit from these techniques as well? In this paper we investigate this question by extending the EvoSuite unit test generation tool with the ability to directly access private APIs and to create mock objects using the popular Mockito framework. However, care needs to be taken that this does not impact the usefulness of the generated tests: For example, a test accessing a private field could later fail if that field is renamed, even if that renaming is part of a semantics-preserving refactoring. Such a failure would not be revealing a true regression bug, but is a false positive, which wastes the developer's time for investigating and fixing the test. Our experiments on the SF110 and Defects4J benchmarks confirm the anticipated improvements in terms of code coverage and bug finding, but also confirm the existence of false positives. However, by ensuring the test generator only uses mocking and reflection if there is no other way to reach some part of the code, their number remains small.
640 Gb/s WDM transmission over 400 km of dispersion-shifted fiber using 1.58 μm band and initial chirp optimization (2002)

Thirty-two 20-Gb/s channels spaced by 100-GHz were transmitted over 400-km of DSF with 80-km repeater spacing. Nonlinear effects in low local dispersion were successfully suppressed by using the 1.58-/spl mu/m band and optimizing the dispersion map and the initial chirp.
Joining NbTi superconductors by ultrasonic welding (1977)

An important consideration in the design and construction of large, high-field, superconducting magnets is the capability to fabricate reliable, high-strength, low-resistance joints. A process for joining NbTi, copper stabilized, superconducting composites by ultrasonic welding is described. This process yields a joint strength comparable to that of the superconducting composite and a resistivity significantly lower than achieved by conventional soft soldering. The superconducting properties of the composite are not affected by the joining process. Scarfing the joint to maintain a constant conductor cross section does not degrade its electrical or mechanical properties. The application of the ultrasonic joining process, including process control, scarfing, and NDT procedures, in the construction of the superconducting magnet (U. S. SCMS) for the joint U. S.-Soviet MHD program is described.
A sparse sampling algorithm for self-optimisation of coverage in LTE networks (2012)

Coverage optimisation is an important self-organising capability that operators would like to have in LTE networks. This paper applies a Reinforcement Learning (RL) based Sparse Sampling algorithm for the self-optimisation of coverage through antenna tilting. This algorithm is better than supervised learning and Q-learning based algorithms as it has the ability to adapt to network environments without prior knowledge, handle large state spaces, perform self-healing and potentially focus on multiple coverage problems.
Pirfenidone in idiopathic pulmonary fibrosis: Figure 1– (2010)

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without proven effective therapy. A multicentre, double-blind, placebo-controlled, randomised phase III clinical trial was conducted in Japanese patients with well-defined IPF to determine the efficacy and safety of pirfenidone, a novel antifibrotic oral agent, over 52 weeks. Of 275 patients randomised (high-dose, 1,800 mg x day(-1); low-dose, 1,200 mg x day(-1); or placebo groups in the ratio 2:1:2), 267 patients were evaluated for the efficacy of pirfenidone. Prior to unblinding, the primary end-point was revised; the change in vital capacity (VC) was assessed at week 52. Secondary end-points included the progression-free survival (PFS) time. Significant differences were observed in VC decline (primary end-point) between the placebo group (-0.16 L) and the high-dose group (-0.09 L) (p = 0.0416); differences between the two groups (p = 0.0280) were also observed in the PFS (the secondary end-point). Although photosensitivity, a well-established side-effect of pirfenidone, was the major adverse event in this study, it was mild in severity in most of the patients. Pirfenidone was relatively well tolerated in patients with IPF. Treatment with pirfenidone may decrease the rate of decline in VC and may increase the PFS time over 52 weeks. Additional studies are needed to confirm these findings.
Repressing the repressor: A new mode of MYC action in lymphomagenesis (2009)

The MYC oncogene is often mutated or amplified in human tumors resulting in increased activity of the transcription factor. Recent evidence suggested that MYC not only regulates expression of protein-coding genes directly, but also controls expression of miRNAs thereby using a second mode to impact on gene expression programs. The importance of miRNAs in MYC-driven tumorigenesis has been enlightened by studying cell line and murine lymphoma models with conditional expression of MYC. The application of microarray technology revealed both MYC-induced and MYC-repressed miRNAs. A miRNA consistently repressed by MYC in multiple tumors was miR-26a indicating that this miRNA might have strong tumor suppressor function for MYC-induced lymphomas. Indeed, ectopic miR-26a expression in MYC-dependent cells resulted in attenuated proliferation and impaired cell cycle progression. When the effector pathway for miR-26a was elucidated, the Polycomb complex protein EZH2, a global regulator of gene expression, was identified as a direct target. The suppression of miR-26a mediated attenuation of EZH2 expression by MYC was shown to play a critical role in lymphomagenesis. Thus, MYC-induced oncogenesis does not only depend on direct targeting of protein-coding genes, but also on modulating them via deregulation of their targeting miRNAs, thereby significantly impacting lymphomagenesis.
Comparative Study between DNA Copy Number Aberrations Determined by Quantitative Microsatellite Analysis and Clinical Outcome in Patients with Stomach Cancer (2004)

RCN aberrations in tumor tissues determined by quantitative microsatellite analysis enable identification of the prognostic factors that correlate with clinical outcome of the patients with stomach cancer.
Context‐Aware Recommender Systems (2011)

Context‐aware recommender systems (CARS) generate more relevant recommendations by adapting them to the specific contextual situation of the user. This article explores how contextual information can be used to create intelligent and useful recommender systems. It provides an overview of the multifaceted notion of context, discusses several approaches for incorporating contextual information in the recommendation process, and illustrates the usage of such approaches in several application areas where different types of contexts are exploited. The article concludes by discussing the challenges and future research directions for context‐aware recommender systems.
Neutrophil activation and acute lung injury (2001)

Neutrophils are considered to be central to the pathogenesis of most forms of acute lung injury (ALI). For the sake of clarity, neutrophil involvement in ALI can be conceptualized as consisting of sequential stages, beginning with their sequestration in the pulmonary microvasculature, followed by adhesion and activation, and culminating in the production of a microbicidal or "effector" response, such as the generation of reactive oxygen species or release of proteolytic enzymes. Great strides have been made in elucidating these various stages of neutrophil involvement. Recent studies have focused on the intracellular signaling pathways that govern neutrophil activation and have elucidated complex cascades of kinases and other intracellular signaling molecules that allow for amplication of the neutrophil response, yet simultaneously confer specificity of a response. We believe that the inflammatory response in ALI may initially be adaptive, such as the pivotal role played by neutrophils in a bacterial or fungal infection. Ultimately, it is the persistence or the dysregulation of neutrophil activation that may lead to ALI. An increased understanding of how neutrophils function will facilitate the design of therapeutic strategies that retain the beneficial aspects of the inflammatory response, while avoiding unnecessary tissue damage.
Structure and Expression of Osteonectin Mrna in Human Tissue (1990)

A cDNA encoding osteonectin was isolated from a human bone cell cDNA library and used to examine osteonectin protein structure, mRNA structure and expression in human tissue. The deduced protein sequence shows complete identity with a recently isolated placental form and extensive homology to mouse and bovine counterparts. The protein is rich in cysteine residues, which are conserved between species except for cys 194 which is only present in the bovine. In the human, osteonectin mRNA is of two sizes, 2.3 and 3.0 kb, the former being dominant in all tissues studied. Human mRNA was detected in the Ewing sarcoma and in non-bone cell and tissue sources. The potential folded structure of osteonectin mRNA was estimated, based on computer predictions, and indicates the presence of a bulge at the 5' end of the message which includes the start of translation. Southern analysis of human genomic DNA using radiolabeled osteonectin cDNA as probe demonstrates a simple banding pattern confirming earlier studies that the osteonectin gene is present in one copy per haploid human genome.
Oxide-nitride-oxide antifuse reliability (2002)

Compact, low-resistance oxide-nitride-oxide (ONO) antifuses are studied for time-dependent dielectric breakdown (TDDB), program disturb, programmed antifuse resistance stability, and effective screen. ONO antifuses are superior to oxide antifuses. No ONO antifuse failures were observed in 1.8 million accelerated burn-in device-hours accumulated on 1108 product units. This is in agreement with the 1/E field acceleration model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Aminohydroxyphosphine Ligand for the Copper-Catalyzed Enantioselective Conjugate Addition of Organozinc Reagents (2006)

An alanine-derived aminohydroxyphosphine ligand was developed for copper-catalyzed asymmetric conjugate addition of organozinc reagents to alpha,beta-unsaturated carbonyl compounds. This new tridentate ligand induces consistently high enantioselectivity in reactions of a variety of acyclic substrates. Theoretical mechanistic analysis suggests that the C-C bond formation takes place through a highly ordered transition state by the coordination of the phosphorus and nitrogen atoms to the copper(III) and zinc(II) atoms, respectively, and of the oxygen anion to both the metal centers.
Full-Duplex Millimeter-Wave Communication (2017)

The potential of doubling the spectrum efficiency of FD transmission motivates us to investigate FD-mmWave communication. To realize FD transmission in the mmWave band, we first introduce possible antenna configurations for FD-mmWave transmission. It is shown that, different from the cases in microwave band FD communications, the configuration with separate Tx/Rx antenna arrays appears more flexible in SI suppression while it may increase some cost and area versus that with the same array. We then model the mmWave SI channel with separate Tx/Rx arrays, where a near-field propagation model is adopted for the LOS path, and it is found that the established LOS-SI channel with separate Tx/Rx arrays also shows spatial sparsity. Based on the SI channel, we further explore approaches to mitigate SI by signal processing, and we focus on a new cancellation approach in FD-mmWave communication, that is, beamforming cancellation. Centered on the CA constraint of the beamforming vectors, we propose several candidate solutions. Lastly, we consider an FD-mmWave multi-user scenario, and show that even if there are no FD users in an FD-mmWave cellular system, the FD benefit can still be exploited in the FD base station. Candidate solutions are also discussed to mitigate both SI and MUI simultaneously.
Smart layers and dumb result (2012)

In this paper, we offer an in-depth IO characterization of the Android-based smartphone. We analyze the IO behaviors of a total of 14 Android applications from six different categories. We examine the correlations among seven IO attributes: originating application, file type, IO size, IO type (read/write), random/sequential, block semantics (Data/Metadata/Journal), and session type (buffered vs. synchronous IO). For the purposes of our study, we develop Mobile Storage Analyzer (MOST), a framework for collecting IO attributes across layers. Let us summarize our findings briefly. SQLite, which is the most popular tool for maintaining persistent data in Android, puts too much burden on the storage. For example, a single SQLite operation (update or insert) results in at least 11 write operations being sent to the storage. These are for creating short-lived files, updating database tables, and accessing EXT4 Journal. From the storage point of view, more than 50% of writes are for EXT4 Journal updating. Excluding Metadata and Journal accesses, 60-80% of the writes are random. More than 50% of the writes are synchronous. 4KB IO accounts for 70% of all writes. In the Android platform, each SQLite and EXT4 filesystem requires a great amount of effort to ensure reliability in supporting transactions and journaling, respectively. When they are combined, the results are rather dumb. The operations of SQLite and EXT4, when combined, generate unnecessarily excessive write operations to the NAND-based storage. This not only degrades IO performance but also significantly reduces the lifetime of the underlying NAND flash storage. The results of this study clearly suggest that SQLite, EXT4, and the underlying NAND-based storage need to be completely overhauled and vertically integrated so as to properly and effectively incorporate their respective characteristics.
One-Step Synthesis of Large-Scale Graphene Film Doped with Gold Nanoparticles at Liquid–Air Interface for Electrochemistry and Raman Detection Applications (2014)

We demonstrated a facile one-step synthesis strategy for the preparation of a large-scale reduced graphene oxide multilayered film doped with gold nanoparticles (RGO/AuNP film) and applied this film as functional nanomaterials for electrochemistry and Raman detection applications. The related applications of the fabricated RGO/AuNP film in electrochemical nonenzymatic H2O2 biosensor, electrochemical oxygen reduction reaction (ORR), and surface-enhanced Raman scattering (SERS) detection were investigated. Electrochemical data indicate that the H2O2 biosensor fabricated by RGO/AuNP film shows a wide linear range, low limitation of detection, high selectivity, and long-term stability. In addition, it was proved that the created RGO/AuNP film also exhibits excellent ORR electrochemical catalysis performance. The created RGO/AuNP film, when serving as SERS biodetection platform, presents outstanding performances in detecting 4-aminothiophenol with an enhancement factor of approximately 5.6 × 10(5) as well as 2-thiouracil sensing with a low concentration to 1 μM. It is expected that this facile strategy for fabricating large-scale graphene film doped with metallic nanoparticles will spark inspirations in preparing functional nanomaterials and further extend their applications in drug delivery, wastewater purification, and bioenergy.
Surface Plasmon Resonance of a Few Particles Linear Arrays (2011)

We present a study of the enhancement of the electric field due to localized surface plasmons in a short chain of metallic nanoparticles with different shapes: spheres, cylinders and spheroids. We calculate numerically the external radiation effect on these chains and analyze besides the shape, also the influence on size, interparticle distances and number of nanoparticles, corroborating that each one plays a definitive role for the enhancement of the electric field. Particularly, we focus on the main features of the electric field in the inter-particle regions, where an enormous increasing is expected due to the longitudinal localized plasmons. The electric field distribution along the chain shows a maximum in the middle of the chain. This fact could be related to a hybridization effect as the gap between particles decreases below 2 nm, we also observe a strong enhancement with the number of nanoparticles. Also regarding the shape we find agreement with reported results on spheroids, moreover we show that lateral coupled cylinders are more flexible to tune the enhancement factor than all other.
The Social Construction of Reality: A Treatise in the Sociology of Knowledge (1967)

Journal Article The Social Construction of Reality: A Treatise in the Sociology of Knowledge. By Peter L. Berger and Thomas Luckmann. New York: Doubleday, 1966. Pp. 199. $5.95 Get access Donald W. Light, Jr. Donald W. Light, Jr. Brandeis University Search for other works by this author on: Oxford Academic Google Scholar Sociology of Religion, Volume 28, Issue 1, Spring 1967, Pages 55–56, https://doi.org/10.2307/3710424 Published: 01 March 1967
Desktop Encyclopedia of Voice and Data Networking (1999)

From the Publisher:
This reference provides the broad, up-to-date coverage needed by both communications professionals and beginners in this fast-moving, acronym-riddled field. More than a quick reference, this sourcebook offers full explanations of important developments and technologies in clear, nontechnical language.. The Desktop Encyclopedia of Voice and Data Networking gives you: the popular format of Muller's Desktop Encyclopedia of Telecommunications, featuring alphabetical listings; 150 illustrations; quick-reference lists of all acronyms and illustrations; coverage of high-speed network backbones such as ATM, Gigabit Ethernet, and FDDI; explanations of the full range of wireless network technologies, including spread spectrum; clear discussions of wide-area solutions such as SONET, ISDN, and Frame Relay; integrated coverage of related issues; and crossreferences to Muller's Desktop Encyclopedia of Telecommunications.
Biotransformation of (–)-Verbenone by Some Fungi (2011)

Biotransformation of (–)-verbenone by Aspergillus niger NRRL 330, Aspergillus wentii MRC 200316 and Penicillium digitatum MRC 500787 afforded (–)-10-hydroxyverbenone. Incubation with A. niger NRRL 330 resulted in with the highest yield.
BRASIL: the Braunschweig mixed-mode-simulator for integrated circuits (1996)

BRASIL consists of a timing simulator for digital MOS circuits coupled with an algorithm for circuit simulation. The timing simulation is based upon a fast macromodelling approach and the calculation of time-variant RC networks. The circuit simulator takes advantage out of structuring the system of nodal equations. With BRASIL a fast simulation of large circuits, with special regards to systems with the need of higher accuracy, is possible.