gebhart/patrepeval huggingface dataset:
Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy (2016)

Preterm labor and infections are the leading causes of neonatal deaths worldwide. During pregnancy, immunological cross talk between the mother and her fetus is critical for the maintenance of pregnancy and the delivery of an immunocompetent neonate. A precise understanding of healthy fetomaternal immunity is the important first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal outcomes. This study combined single-cell mass cytometry of paired peripheral and umbilical cord blood samples from mothers and their neonates with a graphical approach developed for the visualization of high-dimensional data to provide a high-resolution reference map of the cellular composition and functional organization of the healthy fetal and maternal immune systems at birth. The approach enabled mapping of known phenotypical and functional characteristics of fetal immunity (including the functional hyperresponsiveness of CD4<sup>+</sup> and CD8<sup>+</sup> T cells and the global blunting of innate immune responses). It also allowed discovery of new properties that distinguish the fetal and maternal immune systems. For example, examination of paired samples revealed differences in endogenous signaling tone that are unique to a mother and her offspring, including increased ERK1/2, MAPK-activated protein kinase 2, rpS6, and CREB phosphorylation in fetal Tbet<sup>+</sup>CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, B cells, and CD56<sup>lo</sup>CD16<sup>+</sup> NK cells and decreased ERK1/2, MAPK-activated protein kinase 2, and STAT1 phosphorylation in fetal intermediate and nonclassical monocytes. This highly interactive functional map of healthy fetomaternal immunity builds the core reference for a growing data repository that will allow inferring deviations from normal associated with adverse maternal and neonatal outcomes.
Humoral Antibody Responses in Periodontal Disease (1992)

Several forms of periodontal disease are considered to be infectious diseases with associated specific bacteria. This study examined the humoral antibody levels as assayed by ELISA to Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia in adult periodontitis (AP), localized juvenile periodontitis (LJP), rapidly progressive periodontitis (RPP), and in periodontally healthy subjects (HS). Sixty-two of the 64 (96.9%) patients had significantly elevated antibody levels to at least one of the three organisms. Elevated levels of antibodies to P. gingivalis occurred in 82.8% of the RPP, LJP, and AP patients with all 3 disease groups showing greater responses than HS controls. Antibodies to A. actinomycetemcomitans were found in 59.4% of the RPP, LJP, and AP patients and were significantly higher in both LJP and RPP patients. Only 21.9% of the RPP, LJP, and AP patients showed elevated levels to P. intermedia with only significantly higher levels in the RPP and LJP groups. Antibodies to A. actinomycetemcomitans and P. intermedia were rarely found alone (only 5.1% and 2.6% of the patients respectively) but were usually accompanied by P. gingivalis. These results suggest that one or more combinations of these 3 bacteria may play a role in the pathogenesis of these forms of periodontal disease.
An implicit delay fault simulation method with approximate detection threshold calculation (2002)

Existing methodologies for determining delay fault coverages or for building up a delay fault dictionary are sometimes accurate, but rarely fast and easy to implement. Therefore, with the aim of removing these deficiencies, a new and more efficient fault simulation strategy for gate delay faults in combinational or scan-based circuits is presented. This method is based on a critical path tracing algorithm, thus avoiding the explicit simulation of each delay fault in the circuit. The novelty of the solution proposed to compute the detection threshold of a detectable delay fault increases the interest of the method, although it is computed approximately. Simulation results obtained for the ISCAS85 combinational benchmark circuits show the efficiency of the proposed method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Electrostatic analysis and design of a cable-free body area network of sensor nodes using 2D communication over conductive fabric sheets (2005)

In recent years, wearable sensing networks have been the focus of the biotechnology industry. A continuing the question is how best to integrate electronic components with the human body. The authors have devised a body area network that relies on two innovations; the use of conductive fabrics, and the use of DC powerline communication. By combining these innovations, we have created a truly wearable network that allows full generality of sensor location, spatial distribution of the medium to reduce overall bulk, and maintains sufficiently low line impedance for simultaneous power and data delivery over a single conductor. We have created a method for analysis of the transmission properties of conductive fabric garments. In addition, we evaluate the basic transmission line characteristics of the garment. Finally, we present a verification of our model and initial experimental results.
Advances in the management of macular degeneration (2014)

Current management of age-related macular degeneration (AMD) can be divided into two categories: first, anti-vasoendothelial growth factor (anti-VEGF) injection for wet macular degeneration; second, anti-oxidant vitamins for dry macular degeneration. New therapies are being developed for both of these diseases using novel technologies and different modes of administration. The hope is that some of these therapies will achieve significant improvement to current management and prevent future loss of vision in this devastating eye condition.
Secure Boot for Reconfigurable Architectures (2020)

Reconfigurable computing is becoming ubiquitous in the form of consumer-based Internet of Things (IoT) devices. Reconfigurable computing architectures have found their place in safety-critical infrastructures such as the automotive industry. As the target architecture evolves, it also needs to be updated remotely on the target platform. This process is susceptible to remote hijacking, where the attacker can maliciously update the reconfigurable hardware target with tainted hardware configuration. This paper proposes an architecture of establishing Root of Trust at the hardware level using cryptographic co-processors and Trusted Platform Modules (TPMs) and enable over the air updates. The proposed framework implements a secure boot protocol on Xilinx based FPGAs. The project demonstrates the configuration of the bitstream, boot process integration with TPM and secure over-the-air updates for the hardware reconfiguration.
Phase behaviour of argon and krypton adsorbed in mesoporous Vycor glass (2003)

The phase behaviour of Ar and Kr adsorbed in Vycor glass at pressures and temperatures above the bulk triple point and below the bulk critical point has been investigated. Ar is found to condense in the pores ∼2 K above the bulk transition and freeze ∼10 K below the bulk transition. In contrast the condensation transition for Kr is shifted up by 4 K and freezing shifted down by 15 K. There is a pronounced hysteresis (4–6 K) at the liquid/solid phase boundary and a lesser amount (∼2 K) at the gas/liquid boundary. We find clear differences between the pore filling and emptying processes at the gas/liquid phase boundary and evidence of pore blocking on desorption. In addition microbubbles or large gas–liquid interfaces are thought to occur when Kr condenses in the pores but this effect is absent in Ar. Finally, solid Ar in the pores melts in a more continuous way than Kr.
Conditions for a Low-Salinity Enhanced Oil Recovery (EOR) Effect in Carbonate Oil Reservoirs (2011)

Low-salinity enhanced oil recovery (EOR) effects have for a long time been associated with sandstone reservoirs containing clay minerals. Recently, a laboratory study showing low-salinity EOR effects from composite carbonate core material was reported. In the present paper, the results of oil recovery by low-salinity water flooding from core material sampled from the aqueous zone of a limestone reservoir are reported. Tertiary low-salinity effects, 2–5% of original oil in place (OOIP), were observed by first flooding the cores with high-saline formation water (208 940 ppm) and then with 100× diluted formation water or 10× diluted Gulf seawater at 110 °C. It was verified by flooding the core material with distilled water that the core samples contained small amounts of anhydrite, CaSO4(s). The oil recovery was tested under forced displacement using different injection brines and oils with different acid numbers, 0.08, 0.34, and 0.70 mg of KOH/g. The low-salinity effect depended upon mixed wet conditions, and the effect increased as the acid number of the oil increased. No low-salinity effect was observed using a chalk core free from anhydrite. The chemical mechanism for the low-salinity effect is discussed, and in principle, it is similar to the wettability modification taking place by seawater described previously. In field developments, the oil reservoir is normally flooded with the most available water source. For offshore reservoirs, this means seawater or modified seawater. Thus, a relevant question addressed in this paper is can diluted seawater act as a low-saline EOR fluid after a secondary flood with seawater? Previous experiments have shown that both spontaneous imbibition and forced displacement tests using chalk cores, which were free from sulfate, did not show a low-salinity EOR effect when exposed to diluted seawater. This paper shows that, if anhydrite is present in the rock formation, diluted seawater or diluted produced water can act as an EOR injectant to improve recovery over that achieved with high-salinity brines.
Aptamer-Mediated Cancer Gene Therapy (2015)

Cancer as a genetic disorder is one of the leading causes of death worldwide. Conventional anticancer options such as chemo- and/or radio-therapy have their own drawbacks and could not provide a cure in most cases at present. More effective therapeutic strategies with less side effects are urgently needed. Aptamers, also known as chemical antibodies, are single strand DNA or RNA molecules that can bind to their target molecules with high affinity and specificity. Such site-specific binding ability of aptamers facilitates the delivery and interaction of exogenous nucleic acids with diseased genes. Thus, aptamer-guided gene therapy has emerged as a promising anticancer strategy in addition to the classic treatment regimen. Aptamers can directly deliver anti-cancer nucleic acids, e.g. small interfering RNA, micro RNA, antimicroRNA and small hairpin RNA, to cancer cells or function as a targeting ligand to guide nanoparticles containing therapeutic nucleic acids. This review focuses on recent progress in aptamer-mediated gene therapy for the treatment of hepatocellular carcinoma and other types of cancers, shedding light on the potential of this novel approach of targeted cancer gene therapy. Keywords: Aptamer, gene therapy, miRNA, RNAi, cancer, hepatocellular carcinoma.
Quantum Random Number Generator with Programmable Probability Distributions (2018)

We present a method of generating quantum random numbers with arbitrarily defined probability distributions featuring high dimensionality and post-processing free, for significantly improved Monte-Carlo simulations and data analyses.
Long-pulse laser emission from rhodamine 6G (1970)

The properties of the rhodamine 6G flashlamp-pumped circulating dye laser with cyclooctatetraene and cycloheptatriene as triplet-state quenchers are described. Particular attention is given to such observables as pulse duration, frequency sweep, and early termination of the laser pulse. From the experimental results and the theory of dye lasers, it is concluded that the thermal effects may not play a dominant role in such lasers.
Spiro-linked organic small molecules as hole-transport materials for perovskite solar cells (2018)

Organic–inorganic halide perovskite solar cells (PSCs) have attracted great attention as an alternative renewable photovoltaic technology with a power conversion efficiency (PCE) > 22%, which is on par with established technologies.
Sub‐millimeter isotropic MRI for segmentation of subcortical brain regions and brain visualization (2010)

Compared with SPGR-IR, nonselective SPGR allows for consistent segmentation results for basal ganglia regions and improved clarity for visualization of the brain.
Paclitaxel-coated balloon dilation for central airway obstruction (2018)

PCB dilation in benign CAO produced a modest effect in this cohort of challenging airways. Larger prospective studies are needed to assess how a PCB would perform when compared to a non-drug coated balloon.
Sub-Balanced Data and the Mixed Analysis of Variance (1983)

Abstract In the mixed model, it is well known that balanced data are a sufficient condition for an ANOVA with terms that are independent multiples of chi-squared variables (called a proper ANOVA). In this article a weaker condition, which is both necessary and sufficient, is determined and shown to be equivalent to what is defined here as sub-balanced random effects, a condition easily checked in practice. The usual method of generating an ANOVA by fitting sums of squares for a given ordering of the effects in the model is sometimes inadequate with sub-balanced data, requiring instead a spectral decomposition of the covariance matrix. An example is given.
Analysis of current crowding effects in multiturn spiral inductors (2001)

The effective trace resistance of a multiturn spiral inductor operating at high frequencies is known to increase dramatically above its dc value, due to proximity effect or current crowding. This phenomenon, which dominates resistance increases due to skin effect, is difficult to analyze precisely and has generally required electromagnetic simulation for quantitative assessment. Current crowding is studied in this paper through approximate analytical modeling, and first-order expressions are derived for predicting resistance as a function of frequency. The results are validated through comparisons with electromagnetic simulations and compared with measured data taken from a spiral inductor implemented in a silicon-on-sapphire process.
The Effect of Mechanical Excitation on Ionic Conductivity and Related Properties of Polymer Electrolytes (1993)

A recent work1 reported a theoretical basis for enhancement of ionic conductivity in polymer electrolytes under the influence of external mechanical excitation. This paper presents an experimental evidence for the conductivity enhancement. The conductivity of a Li/polymer/Li half cell was increased by a factor of three as the frequency of external mechanical excitation was varied from 0 to 10 kHz. The mechanism of conductivity enhancement has been explained on the basis of absorption of mechanical energy by polymer chains that in turn assist the transport of conducting ions. The enhanced conductivity may subsequently affect the performance of electrochemical devices. Discharge rates of some primary polymer batteries as a function of mechanical excitation were measured, and the results suggest that they are excitation dependent.
Volitional control of single cortical neurons in a brain–machine interface (2011)

Volitional control of cortical activity is relevant for optimizing control signals for neuroprosthetic devices. We explored the control of firing rates of single cortical cells in two Macaca nemestrina monkeys by providing visual feedback of neural activity and rewarding changes in cell rates. During 'brain-control' sessions, the monkeys modulated the activity of each of 246 cells to acquire targets requiring high or low discharge rates. Cell control improved more than two-fold from the beginning of practice to peak performance. Cell activity was modulated substantially more during brain control than during wrist movements. When recording stability permitted, the monkeys practiced controlling activity of the same cells across multiple days. The performance improved substantially for 27 of 36 cells when practicing brain control across days. The monkeys maintained discharge rates within each target for 1 s, but could maintain rates for up to 3 s for some cells, and performed the brain-control task equally well using cells recorded from the pre-central cortex compared to cells in the post-central cortex, and independently of any directional tuning. These findings demonstrate that arbitrary single cortical neurons, regardless of the strength of directional tuning, are capable of controlling cursor movements in a one-dimensional brain-machine interface. It is possible that direct conversion of activity from single cortical cells to control signals for neuroprosthetic devices may be a useful complementary strategy to population decoding of the intended movement direction.
Synthesis of Natural Product Inspired Compound Collections (2009)

Natural products, their derivatives, and their analogues are among the most important sources for new drug candidates and tools for chemical biology and medicinal chemistry research. Therefore, there is a need for the development of efficient synthesis methods which give access to natural product derived and inspired compound collections. To meet this challenge, the requirements of multistep stereoselective syntheses, and the logic and methodology of natural product total synthesis need to be translated and adapted to the methods and formats for the synthesis of compound collections. Recent developments in the synthesis of natural product inspired compound collections having carbocyclic and heterocyclic scaffolds highlight the fact that this goal can be successfully attained. The progress made has paved the way for the integration of natural product inspired compound collections into medicinal chemistry and chemical biology research.
A new Golay code system for ultrasonic pulse echo measurements (1990)

Many measurements involving ultrasonic pulse echo techniques are limited by poor signal-to-noise ratios. It is well known that random or pseudorandom codes in conjunction with cross correlation can enhance signal-to-noise ratio and it has been shown that a form of pseudo-random sequence known as a Golay code enables the signal-to-noise ratio improvement to be obtained whilst requiring only two sequences of the code to overcome problems of self noise. A significant parameter associated with a system employing this technique is the amplitude of the coded signal applied to the transducer. The authors describe the development and application of a system having a transmitter capable of delivering peak-to-peak signals of 100 V. Measurements show that this instrument provides considerable signal-to-noise improvements when compared with conventional equipment.
Botulinum Toxin and Human Serum Albumin—Reply (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal
Ultrastructural Damage to the Organ of Corti during Acute Experimental Escherichia coli and Pneumococcal Meningitis in Guinea Pigs (1996)

Experimental meningitis was induced in 16 pigmented guinea pigs by subarachnoid inoculation of mid log-phase 1 x 10(9) E. coli K-12 (n = 8) or 5 x 10(7) Streptococcus pneumoniae type 2 (n = 8). Animals were killed at various times between 3 and 12 h after inoculation and the ultrastructure of the organ of Corti (including the basilar membrane) was examined with high resolution scanning electron microscopy. Both E. coli and S. pneumoniae induced meningitis and invaded scala tympani. In both types of meningitis the apical surface of inner supporting cells developed craters. inner hair cell stereocilia were also disrupted. In pneumococcal meningitis both these lesions were more pronounced but in addition there were breaks in the junctions between inner hair cells and their adjacent supporting cells and there was ballooning and rupture of the apical surface of outer hair cells. Damage to the organ of Corti after bacterial invasion of the inner ear may be one of the mechanisms by which bacterial meningitis can cause deafness. The more severe cochlear lesions induced by S.pneumoniae may explain the higher incidence of deafness after pneumococcal meningitis.
EFFECT OF CYCLOSPORINE AND TACROLIMUS ON THE GROWTH OF EPSTEIN-BARR VIRUS-TRANSFORMED B-CELL LINES1,2 (1998)

CsA and TAC enhance the survival of EBV-transformed B-cell lines. CsA and TAC promote or augment SLCL growth through protection from cell death but do not affect cell division. The inhibition of cell death by CsA and TAC may contribute to the expansion of EBV-infected cells in immunosuppressed individuals.
GeoMesa: a distributed architecture for spatio-temporal fusion (2015)

Recent advances in distributed databases and computing have transformed the landscape of spatio-temporal machine learning. This paper presents GeoMesa, a distributed spatio-temporal database built on top of Hadoop and column-family databases such as Accumulo and HBase, that includes a suite of tools for indexing, managing and analyzing both vector and raster data. The indexing techniques use space filling curves to map multi-dimensional data to the single lexicographic list managed by the underlying distributed database. In contrast to traditional non-distributed RDBMS, GeoMesa is capable of scaling horizontally by adding more resources at runtime; the index rebalances across the additional resources. In the raster domain, GeoMesa leverages Accumulo's server-side iterators and aggregators to perform raster interpolation and associative map algebra operations in parallel at query time. The paper concludes with two geo-time data fusion examples: using GeoMesa to aggregate Twitter data by keywords; and georegistration to drape full-motion video (FMV) over terrain.
Truth, Sojourner (ca. 1797–1883) (2009)

Born around 1797 in Hurly, New York, and given the name Isabella, Sojourner Truth, who later in life earned fame as an evangelist, abolitionist, and women's rights advocate, remained a slave until 1827 when, on July 4, African Americans born before July 4, 1799 were freed in accordance with New York's 1817 emancipation statute. Her owners during her first 30 years included Johannes Hardenbergh and his son Charles Hardenbergh, who sold her to John Neely in 1806. Martinus Schryver bought her in 1808, and two years later she was sold to John Dumont.