gebhart/patrepeval huggingface dataset:
The domain structure of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides (1998)

Protoporphyrinogen oxidase (EC 1-3-3-4), the 60-kDa membrane-bound flavoenzyme that catalyzes the final reaction of the common branch of the heme and chlorophyll biosynthesis pathways in plants, is the molecular target of diphenyl ether-type herbicides. It is highly resistant to proteases (trypsin, endoproteinase Glu-C, or carboxypeptidases A, B, and Y), because the protein is folded into an extremely compact form. Trypsin maps of the native purified and membrane-bound yeast protoporphyrinogen oxidase show that this basic enzyme (pI > 8.5) was cleaved at a single site under nondenaturing conditions, generating two peptides with relative molecular masses of 30,000 and 35,000. The endoproteinase Glu-C also cleaved the protein into two peptides with similar masses, and there was no additional cleavage site under mild denaturing conditions. N-terminal peptide sequence analysis of the proteolytic (trypsin and endoproteinase Glu-C) peptides showed that both cleavage sites were located in putative connecting loop between the N-terminal domain (25 kDa) with the betaalphabeta ADP-binding fold and the C-terminal domain (35 kDa), which possibly is involved in the binding of the isoalloxazine moiety of the FAD cofactor. The peptides remained strongly associated and fully active with the Km for protoporphyrinogen and the Ki for various inhibitors, diphenyl-ethers, or diphenyleneiodonium derivatives, identical to those measured for the native enzyme. However, the enzyme activity of the peptides was much more susceptible to thermal denaturation than that of the native protein. Only the C-terminal domain of protoporphyrinogen oxidase was labeled specifically in active site-directed photoaffinity-labeling experiments. Trypsin may have caused intramolecular transfer of the labeled group to reactive components of the N-terminal domain, resulting in nonspecific labeling. We suggest that the active site of protoporphyrinogen oxidase is in the C-terminal domain of the protein, at the interface between the C- and N-terminal domains.
Development of an intracutaneous depot for drugs. Binding, drug accumulation and retention studies, and mechanism of depot. (1991)

In previous studies we reported that the permeation of dexamethasone and hydrocortisone across the skin was decreased and penetration into the skin was increased in the presence of Transcutol (TC) when compared to water as a solvent. The objective of this investigation was to study the effect of TC on the binding of dexamethasone and hydrocortisone to the skin, and on the accumulation and retention in the skin. Adsorption and desorption studies were conducted for dexamethasone and hydrocortisone with full thickness skin (FTS), and epidermis. The amount of dexamethasone and hydrocortisone adsorbed and desorbed with FTS and epidermis was essentially the same. In the presence of TC the amount of dexamethasone and hydrocortisone adsorbed was increased by 100% with both FTS and epidermis, whereas there was no difference in the amount of dexamethasone and hydrocortisone desorbed. A topical delivery system was developed with and without TC and was evaluated in vivo using the rat as an animal model for hydrocortisone accumulation after multiple dosing. The systemic body burden was reduced by 70% and skin retention of hydrocortisone was increased by 100% in all the layers of the skin. The detection of hydrocortisone accumulation and retention were studied by autoradiography and electron microscopy, and the results support the hydrocortisone depot in the skin due to TC.
Magnetic Resonance Imaging of Articular Cartilage (1998)

MR imaging is the best noninvasive method for the evaluation of articular cartilage. Recent studies have clarified the MR appearance of normal articular cartilage and proven that MR imaging can detect chondral lesions with high accuracy. Quantitative imaging holds promise for the accurate determination of cartilage volumes and thickness measurements, as well as the ability to detect early chondral degeneration and biochemical changes before gross morphologic changes occur.
HELIPLAT: Design, Aerodynamic, Structural Analysis of Long- Endurance Solar-Powered Stratospheric Platform (2004)

This paper presents the design and manufacture of the first European Very Long-Endurance Stratospheric Unmanned Air Vehicle, HeliPlat® (HELIos PLATform). This vehicle is a monoplane with eight brushless motors, a twin-boom tail type and two rudders. A computer program has been developed to carry out the platform design. To minimize airframe weight, high modulus carbon fibre composite material has been used extensively. Airfoil coordinates and wing planform have been optimized in order to achieve the best possible aerodynamic efficiency by using integral panel/boundary-layer methods and also to obtain the minimum possible induced drag with respect to local Reynolds airfoil. To this effect, several wind-tunnel tests were carried out so as to compare the analytically predicted airfoil performances. After an initial configuration had been worked out, a scale technological demonstrator (wing span 24 m) was designed, manufactured, and tested under shear, bending, and torsion loads. Finite element analysis was also carried out in order to predict the static and dynamic behaviour of both the full-size and scale model versions of the HeliPlat structure. The preliminary static test resulted in a high correspondence.
Comparison of striatal <sup>18</sup> F‐dopa uptake in adult‐onset dystonia‐parkinsonism, Parkinson's disease, and dopa‐responsive dystonia (1993)

We studied six patients with adult-onset dystonia-parkinsonism (DYS-P) with 18F-6-fluoro-dopa (18F-dopa) positron emission tomography and compared their influx constants (Ki values) with those of six patients with classical childhood-onset dopa-responsive dystonia (DRD), 12 age-matched Parkinson's disease (PD) patients without dystonia, and 21 normal controls. The DYS-P group had significantly reduced mean caudate (67% of normal) and putamen (45% of normal) 18F-dopa uptake. These Ki values were similar to mean caudate and putamen Ki values obtained for the PD group. In contrast, the DRD group showed minor reductions in mean caudate (9%) and putamen (18%) 18F-dopa uptake when compared with normals. The mean caudate:putamen Ki ratio was 1.7 in the DYS-P group and 2.1 in the PD group. In the DRD and normal groups, the caudate:putamen ratios were close to unity. The findings of this study are that adult-onset DYS-P targets the nigrostriatal dopaminergic projections in a pattern similar to PD, with the putamen being more affected. This provides support for the hypothesis that DYS-P may be a phenotypic variant of Lewy body disease. DYS-P seems distinct from childhood-onset DRD, in which striatal 18F-dopa uptake is either normal or only mildly reduced.
Improvement of anther culture technique: Activated charcoal bound in agar medium in combination with liquid medium and elevated CO<sub>2</sub> concentration (1982)

Anthers of different species of the genera Anemone, Clematis, Papaver and Nicotiana were cultured by floating on a liquid medium which overlay an agarified charcoal medium . This technique proved to be superior to conventional methods i.e. culture on either solid or liquid media. Cold treatment of Anemone anthers for 7 days after inoculation on the double layer medium gave about the same frequency of embryos per anther as corresponding cultures cold treated before inoculation. An elevation of the CO 2 concentration to 2% stimulated embryogenesis in anther cultures of Anemone canadensis, Anemone vitifolia, Papaver setigerum and Papaver radicatum . Cold treatment of cultures of Anemone canadensis inhibited embryogenesis if the ensuing culture was performed in 2% CO 2. On the other hand, cold treatment was stimulating, with an optimum of about 20 days, if the cultures were maintained in normal air. Chemical analysis of untreated anthers of Anemone canadensis showed the presence of abscisic acid (2.2 × 10 −6 g/g anthers). Cold treatment reduced the concentration of abscisic acid to 0.6 × 10 −6 g/g anthers. By use of assays with Lemna gibba as test organism, activated charcoal was shown to adsorb abscisic acid that was added to the medium. Medium treated with charcoal before inoculation of anthers of Anemone canadensis provided to inhibit embryo production.
TISSUE DISTRIBUTION OF THE PK ANTIGEN AS DETERMINED BY A MONOCLONAL ANTIBODY (1985)

Using an anti-Pk monoclonal antibody (mAb) designated CPK-1, the expression of the Pk antigen was assessed on normal human tissue from non-Pk individuals. Although the Pk antigen was detected on fibroblasts and blood vessels as previously reported, it was also found on smooth muscle cells of the digestive tract and the urogenital system. Pk was also found on glandular cells of the stomach, oesophagus and prostate. Additionally, CPK-1 reacted weakly with oesophagus squamous cells, and a small number of glomeruli and tubules in the kidney. The mechanism of expression of the Pk determinant in non-Pk individuals is discussed.
Non-linear phase apodisation techniques for arrayed-waveguide grating passband control (1998)

The authors have presented a series of novel techniques for improving the passband flatness of arrayed-waveguide gratings (AWGs). Either phase or complex amplitude functions are used to produce the required broadening without excessive compromise on the intrinsic wavelength selectivity. Minimum passband variance parameters for both the phase and complex techniques have been shown, the latter producing a near-ideal trapezoidal passband characteristic. (5 pages)
1.5 V Sub-mW CMOS Interface Circuit for Capacitive Sensor Applications in Ubiquitous Sensor Networks (2008)

In this paper, a low-power CMOS interface circuit is designed and demonstrated for capacitive sensor applications, which is implemented using a standard 0.35-m CMOS logic technology. To achieve low-power performance, the low-voltage capacitance-to-pulse-width converter based on a self-reset operation at a supply voltage of 1.5 V is designed and incorporated into a new interface circuit. Moreover, the external pulse signal for the reset operation is made unnecessary by the employment of the self-reset operation. At a low supply voltage of 1.5 V, the new circuit requires a total power consumption of 0.47 mW with ultra-low power dissipation of 157 W of the interfacecircuit core. These results demonstrate that the new interface circuit with self-reset operation successfully reduces power consumption. In addition, a prototype wireless sensor-module with the proposed circuit is successfully implemented for practical applications. Consequently, the new CMOS interface circuit can be used for the sensor applications in ubiquitous sensor networks, where low-power performance is essential.
Large-scale Classification of Fine-Art Paintings: Learning The Right Metric on The Right Feature (2015)

In the past few years, the number of fine-art collections that are digitized and publicly available has been growing rapidly. With the availability of such large collections of digitized artworks comes the need to develop multimedia systems to archive and retrieve this pool of data. Measuring the visual similarity between artistic items is an essential step for such multimedia systems, which can benefit more high-level multimedia tasks. In order to model this similarity between paintings, we should extract the appropriate visual features for paintings and find out the best approach to learn the similarity metric based on these features. We investigate a comprehensive list of visual features and metric learning approaches to learn an optimized similarity measure between paintings. We develop a machine that is able to make aesthetic-related semantic-level judgments, such as predicting a painting's style, genre, and artist, as well as providing similarity measures optimized based on the knowledge available in the domain of art historical interpretation. Our experiments show the value of using this similarity measure for the aforementioned prediction tasks.
Decreased renal mRNA expression of TRPM6 is associated with hypomagnesemia in C57BL/6 asthmatic mice. (2010)

This study indicates that the consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
Synthesis of 2,4-Difluoroaniline and 1,3-Difluorobenzene from 1,2,4-Trichlorbenzene (1994)

Abstract Nitration of inexpensive 1,2,4-trichlorobenzene gave 2,4,5-trichloronitrobenzene (90%) which was treated with KF to form 2,4-difluoro-5-chloronitrobenzene (70%). This was selectively hydrogenated over Pd/C to give 2,4-difluoroaniline (80%). Deamination afforded 1,3-difluorobenzene. The sequence avoids the need for costly 1,3-dichlorobenzene.
Structural characterization of bis(L-methionato)zinc(II), Zn(L-met)2 (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural characterization of bis(L-methionato)zinc(II), Zn(L-met)2Roxy Bream. Wilson, Patrice. De Meester, and Derek J. HodgsonCite this: Inorg. Chem. 1977, 16, 6, 1498–1502Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/ic50172a052https://doi.org/10.1021/ic50172a052research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Measurement and diagnosis of address misconfigured P2P traffic (2011)

Through measurement study, we discover an interesting phenomenon, P2P address misconfiguration, in which a large number of peers send P2P file downloading requests to a "random" target on the Internet. Through measuring three large datasets spanning four years and across five different /8 networks, we find address-misconfigured P2P traffic on average contributes 38.9 percent of Internet background radiation, increasing by more than 100 percent every year. To detect and diagnose such unwanted traffic, we design the P2PScope, a measurement tool. After analyzing about 2 Tbytes of data and tracking millions of peers, we found that in all the P2P systems, address misconfiguration is caused by resource mapping contamination: the sources returned for a given file ID through P2P indexing are not valid. Different P2P systems have different reasons for such contamination. For eMule, we find that the root cause is mainly a network byte-order problem in the eMule Source Exchange protocol. For BitTorrent misconfiguration, one reason is that anti-P2P companies actively inject bogus peers into the P2P system. Another reason is that the KTorrent implementation has a byte-order problem.
The Effect of Influenza Vaccination on IL2 Production in Healthy Elderly: Implications for Current Vaccination Practices (1992)

Age-related senescence of T-cell mediated responses is well recognized. This study was designed to determine how aging affects the T-cell mediated Interleukin 2 (IL2) response to influenza vaccination. A group of healthy elderly individuals were compared to a control group of healthy young adults for their response to the 1990 influenza vaccine. Cultures of peripheral blood mononuclear cells (PBMC) were prepared from venous blood samples taken prevaccination (pre) and 8 and 12 weeks post-vaccination (post). PBMC cultures stimulated with inactivated A/Shanghai/16/89 (contained in the 1990 vaccine) and A/Philippine/2/82 (not contained in the vaccine) were assayed for peak IL2 activity. We find that after influenza vaccination, there was an insignificant increase in IL2 activity when PBMC from the young control group were stimulated with A/Shanghai/16/89 (pre, 5.14 U/mL/10(6) PBMC; post, 6.64 U/mL/10(6) PBMC) but there was a significant increase in IL2 activity when stimulated with A/Phillippine/2/82 (pre, 1.5 U/mL/10(6) PBMC; post, 8.3 U/mL/10(6) PBMC). In similar cultures of PBMC from the elderly group, there was a significant increase in IL2 response to both A/Shanghai/16/89 (pre, 1.6 U/mL/10(6) PBMC; post, 3.5 U/mL/10(6) PBMC) and A/Philippine/2/82 (pre, 0.86 U/mL/10(6) PBMC; post, 8.3 U/mL/10(6) PBMC). Measurements of CD4+/CD8+ populations were not affected by vaccination and were not significantly different in the two groups. Subgroup analysis of the elderly group revealed that previous influenza vaccination in 1989 did not significantly affect IL2 levels measured in the present study. This study shows that in healthy elderly, influenza vaccination effectively restores IL2 activity to normal. There appears to be an age-related decrease in the duration of T-cell memory.(ABSTRACT TRUNCATED AT 250 WORDS)
Hair Damage and Wave Efficiency according to the Degree of Alkalinity in Permanent Wave (2012)

Diversification and individualization are pursued to fulfill the increasing human desire for beauty. There are many methods to change human appearances; of these, a permanent wave is often applied to improve beauty. A permanent wave uses physical and chemical methods to break and reform the bonds of natural hair. Thus, research into the optimized conditions for permanent waves is necessary to minimize hair damage and improve the efficiency of the treatment. The object of this study is to examine the effect of varying the alkalinity (8%, 12%, and 16%) of the permanent wave treatment on the wave efficiency, degree of hair damage via tensile strength, and degree of hair protein release. The results indicate that the treatment with the highest alkalinity (16%) is more effective than that with 8% alkalinity; however, the degree of hair damage when treated with the 16% alkalinity wave is higher than with the 8% alkalinity wave. Additionally, hair proteins increasingly dissolve with increasing alkalinity of the permanent wave.
Simultaneous subordinate microthreading (SSMT) (1999)

Current work in Simultaneous Multithreading provides little benefit to programs that aren't partitioned into threads. We propose Simultaneous Subordinate Microthreading (SSMT) to correct this by spawning subordinate threads that perform optimizations on behalf of the single primary thread. These threads, written in microcode, are issued and executed concurrently with the primary thread. They directly manipulate the microarchitecture to improve the primary thread's branch prediction accuracy, cache hit rate, and prefetch effectiveness. All contribute to the performance of the primary thread. This paper introduces SSMT and discusses its potential to increase performance. We illustrate its usefulness with an SSMT machine that executes subordinate microthreads to improve the branch prediction of the primary thread. We show simulation results for the SPECint95 benchmarks.
Accessing multimedia network services (1992)

An experiment in architecture design for multimedia network services is described. The results obtained suggest that reference models for generalized hypertext systems, commonly called hypermedia systems, may be more readily formulated within the object-oriented system paradigm than other approaches currently under consideration for hypertext alone. The development of the software architecture for Libernet.91, a system for remote access and control of multimedia source material, is discussed. Concepts of object-oriented database management systems are outlined. The underlying architecture of the implemented system is compared to the Dexter hypertext reference model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The Bibliographical Study on Development of Yackwa (1987)

The cooking processes of Yackwa writen in 27 Korean books were reviewed. The changes of the names, shapes, materials and methods of dough, and the methods of frying, the materials and methods of soaking, garnishes were reviewed based on the historical literatures. 1. The changes of names of Yackwa were Yackwa, Kwajul, Chokwa and the shapes were bird, animal, round or cubic. The diameter was about 3.5cm, and thickness was from 0.5cm to 1.5cm. 2. The major ingredients of Yackwa were flour, honey, sesame oil and alcohol beverages. Sometimes, soybean powder and rice powder were used instead of flour, and chochung, sugar water, sugar syrup were used instead of honey. Sesame oil was usually used but salad oil were used occasionally. Usually pure liquor, distilled spirits, rice wine, cloudy and coarse rice wine, whisky were used as alcoholic ingredient and water was used at boiling state. Sesame and sesame salt, ginger and ginger juice, pepper powder, pine nuts powder, salt were used as minor ingredients. 3. Though the flour was kneaded extensively or gently, the latter was peculier since 1940. 4. The dough was fried in oil at for minutes. at that time, The shape will be broken if temperature of oil is too low and too harden if temperature is too high. 5. Fried dough was soaked in honey before 1940, but thereafter other sweeteners, such as chochung, syrup were also used. Ginger juice, dried ginger, citron juice were used for flavor. 6. For enhancing the flavor and softening excess oil was removed from the fried Yackwa, and then it was soaked in honey. 7. The garnishes of Yackwa were pine nuts powder, cinnamon powder, sugar, etc.
Addition of a Functionalized Isoprene Unit to an Allyl Alcohol. III. The reaction with optically active <i>cis</i>‐carveol (1970)

Abstract Provided the temperature is kept under 150°, diene ethers of allyl alcohols rearrange in the double Claisen ‐ Cope reaction largely by a sigmatropic process in both stages. This was demonstrated by using the 2‐methylbutadienyl ether of (−)‐ cis ‐carveol, when the product obtained after the two rearrangements was optically active. To check the extent of chirality loss, the same product was synthesized by a route involving only one sigmatropic reaction instead of two. When the reaction occurs at higher temperature, much more chirality is lost, corresponding to the intervention of a diradical process.