gebhart/patrepeval huggingface dataset:
Chemotactic cell trapping in controlled alternating gradient fields (2011)

Directed cell migration toward spatio-temporally varying chemotactic stimuli requires rapid cytoskeletal reorganization. Numerous studies provide evidence that actin reorganization is controlled by intracellular redistribution of signaling molecules, such as the PI4,5P2/PI3,4,5P3 gradient. However, exploring underlying mechanisms is difficult and requires careful spatio-temporal control of external chemotactic stimuli. We designed a microfluidic setup to generate alternating chemotactic gradient fields for simultaneous multicell exposure, greatly facilitating statistical analysis. For a quantitative description of intracellular response dynamics, we apply alternating time sequences of spatially homogeneous concentration gradients across 300 μm, reorienting on timescales down to a few seconds. Dictyostelium discoideum amoebae respond to gradient switching rates below 0.02 Hz by readapting their migration direction. For faster switching, cellular repolarization ceases and is completely stalled at 0.1 Hz. In this "chemotactically trapped" cell state, external stimuli alternate faster than intracellular feedback is capable to respond by onset of directed migration. To investigate intracellular actin cortex rearrangement during gradient switching, we correlate migratory cell response with actin repolymerization dynamics, quantified by a fluorescence distribution moment of the GFP fusion protein LimEΔcc. We find two fundamentally different cell polarization types and we could reveal the role of PI3-Kinase for cellular repolarization. In the early aggregation phase, PI3-Kinase enhances the capability of D. discoideum cells to readjust their polarity in response to spatially alternating gradient fields, whereas in aggregation competent cells the effect of PI3-Kinase perturbation becomes less relevant.
Vps27 recruits ESCRT machinery to endosomes during MVB sorting (2003)

Down-regulation (degradation) of cell surface proteins within the lysosomal lumen depends on the function of the multivesicular body (MVB) sorting pathway. The function of this pathway requires the class E vacuolar protein sorting (Vps) proteins. Of the class E Vps proteins, both the ESCRT-I complex (composed of the class E proteins Vps23, 28, and 37) and Vps27 (mammalian hepatocyte receptor tyrosine kinase substrate, Hrs) have been shown to interact with ubiquitin, a signal for entry into the MVB pathway. We demonstrate that activation of the MVB sorting reaction is dictated largely through interactions between Vps27 and the endosomally enriched lipid species phosphatidylinositol 3-phosphate via the FYVE domain (Fab1, YGL023, Vps27, and EEA1) of Vps27. ESCRT-I then physically binds to Vps27 on endosomal membranes via a domain within the COOH terminus of Vps27. A peptide sequence in this domain, PTVP, is involved in the function of Vps27 in the MVB pathway, the efficient endosomal recruitment of ESCRT-I, and is related to a motif in HIV-1 Gag protein that is capable of interacting with Tsg101, the mammalian homologue of Vps23. We propose that compartmental specificity for the MVB sorting reaction is the result of interactions of Vps27 with phosphatidylinositol 3-phosphate and ubiquitin. Vps27 subsequently recruits/activates ESCRT-I on endosomes, thereby facilitating sorting of ubiquitinated MVB cargoes.
ChemInform Abstract: SYNTHESIS OF APPARENTLY COVALENT DOUBLE ALKOXIDES OF RUBIDIUM AND CESIUM (1977)

Abstract Die stöchiometrische Umsetzung entsprechender Metallisopropoxide miteinander in Isopropanol führt zu Produkten der Zusammensetzung (I)‐(III), in denen die Metalle vermutlich über Isopropoxy‐Brücken miteinander verbunden sind.
Perceptual Error Measure for Sampled and Interpolated Images (1997)

Error measures quantify the difference between a reproduced image and the corresponding unprocessed “original” image. Unfortunately, most of the existing error measures such as the mean-square-error (MSE) correlate poorly with the perceived quality of the reproduced images. The reason is that these measures either do not or insufficiently take the properties of the human visual system into account. The distance in a perceptual space spanned by artifacts relevant to the image reproduction techniques is used as a measure of the impairment of the reproduced image relative to the original image. For sampling and interpolation, we show how a two-dimensional perceptual space with the sensorial strengths of periodic structure and blur along the axes can be constructed from the physical parameters. The quantitative perceptual error measure can be used to determine a perceptually optimal combination of sampling and interpolation. The optimization problem is shown to be equivalent to minimizing a cost function known from standard regularization theory. The optimal solution is a compromise between conflicting demands in the perceptual space.
Carboxyl-terminal deletion analysis of the Streptococcus mutans glucosyltransferase-I enzyme (1990)

Sequential deletion of the carboxyl-terminal amino acids (including the six direct repeating units) of the glucosyltransferase-I (GTF-I) enzyme of Streptococcus mutans revealed differential effects on sucrase and GTF activities. Removal of all but one repeating unit resulted in a truncated enzyme with significant sucrase activity but no detectable GTF activity. These results are compatible with the presence of two functional domains in the enzyme.
Lectures for Mobile Devices, Evaluating "iPod/PDA-casting" Technology and Pedagogy (2007)

This paper explores the use of recorded lectures in formats for mobile devices (Video iPod and PDA) in a graduate computer science program using a software system developed at this university. Recordings are converted to formats for mobile devices along with an interface that allows students to subscribe to a course to receive automatic lecture downloads. The technology, pedagogy, student perceptions of the technology, and impact on educational success is explored in this paper. The mobile device lectures are in addition to the existing distance-learning option that allows students to attend live lectures by using a Web browser, and to view recorded lectures. Students self-select whether to attend on-campus in the classroom, attend live over the Internet, or to view the recorded lectures
Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 <i>(Commentary, p. 3026)</i> (2019)

Spring, Maryland, for a 2-day public workshop entitled "Pathogen Reduction Technologies for Blood Safety." The workshop opened with welcome remarks from Dr. Nicole Verdun, Director, Office of
Enhanced resonant tunneling real-space transfer in δ-doped GaAs/InGaAs gated dual-channel transistors grown by MOCVD (1996)

We report the observation of pronounced N-shaped negative differential resistance (NDR) and negative transconductance at high drain and gate fields in /spl delta/-doped GaAs/InGaAs gated dual-channel transistors (DCTs) by tunneling real-space transfer (TRST). By virtue of varying the sheet density of the /spl delta/-doping layer as well as the thickness of the GaAs barrier, pronounced multiple-state NDR characteristics were obtained accompanying the gate current characteristic at room temperature. A peak-to-valley current ratio (PVR) of 15 was obtained which, to our knowledge, is the highest among the reported TRST devices at room temperature. The proposed devices possess potential advantages of ease of growth and fabrication.
Review: <i>When the West Is Gone</i>, by Frederic L. Paxson and <i>The Rediscovery of the Frontier</i>, by Percy Boynton (1932)

Book Review| June 01 1932 Review: When the West Is Gone, by Frederic L. Paxson and The Rediscovery of the Frontier, by Percy Boynton When the West Is GoneFrederic L. PaxsonThe Rediscovery of the FrontierPercy Boynton John C. Parish John C. Parish Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1932) 1 (2): 254–256. https://doi.org/10.2307/3633697 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation John C. Parish; Review: When the West Is Gone, by Frederic L. Paxson and The Rediscovery of the Frontier, by Percy Boynton. Pacific Historical Review 1 June 1932; 1 (2): 254–256. doi: https://doi.org/10.2307/3633697 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1932 The Arthur H. Clark Company Article PDF first page preview Close Modal You do not currently have access to this content.
X-ray-absorption fine structure study on devitrification of ultrafine amorphous Ni-B alloys (2001)

X-ray-absorption fine structure (XAFS), x-ray diffraction, and differential thermal analysis have been combined to investigate the structure of ultrafine amorphous ${\mathrm{Ni}}_{70}{\mathrm{B}}_{30}$ alloy during the crystallization process. The XAFS results demonstrate that a fcc-like nanocrystalline Ni phase with a medium-range order is formed at 573 K where the first exothermic process is observed. We confirmed that the metastable intermediate states consist of the two phases, i.e., nanocrystalline Ni and crystalline ${\mathrm{Ni}}_{3}\mathrm{B}$ alloy. The results support the Riveiro et al.'s scenario [J. Magn. Magn. Mater. 188, 153 (1998)] for the devitrification of NiB alloy, in that crystalline phases of ${\mathrm{Ni}}_{3}\mathrm{B}$ and Ni-rich NiB alloy are formed as the intermediate states. Based on the complementary information obtained by the three techniques, we present a simple mechanism of crystallization process for the ultrafine amorphous ${\mathrm{Ni}}_{70}{\mathrm{B}}_{30}$ alloy.
Systolic array implementation for fuzzy evidential reasoning systems (2002)

This paper suggests a systolic array implementation of fuzzy expert systems based on a fuzzy evidential reasoning methodology. Evidential reasoning systems are compute-bound in general, and fuzzy systems match a larger number of rules than simple symbolic reasoning systems. The fuzzy evidential system proposed, which is a combination of both, needs much more computation than either of these two independently. To speed up processing in such a system the suggested implementation is useful.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Studies on scalability and scaling laws for the plasma focus: similarities and differences in devices from 1 MJ to 0.1 J (2010)

A comprehensive analysis of scaling laws for plasma focus devices producing neutrons is presented. Similarities and differences in plasma focus devices working with stored energies ranging from 1 MJ to 0.1 J are found. First, a brief review listing the most important results achieved by the Thermonuclear Plasma Department of the Chilean Nuclear Energy Commission, CCHEN, is presented. The aim of the work at CCHEN has been to characterize the physics of dense plasma foci and also to carry out the design and construction of smaller devices—in terms of both input energy and size—capable of providing dense hot plasmas. Certain scaling rules have been found from this research. These rules combined with other scaling laws have been applied to design and construct plasma focus devices with storage energy in a region never explored before (tens of joules and less than 1 J). Thus, a comprehensive analysis also including results from other groups is presented. In particular, all the devices, from the largest to the smallest, maintain the same value of ion density, magnetic field, plasma sheath velocity, Alfven speed and the quantity of energy per particle. Therefore, fusion reactions are even possible to obtain in ultraminiature devices (driven by generators of 0.1 J for example), as they are in the larger devices (driven by generators of 1 MJ). However, the stability of the plasma pinch highly depends on the size and energy of the device.
The New Frontier in Heat Transfer: Microscale and Nanoscale Technologies (2006)

Keywords: Microscale technology ; Macroscale technology ; Nanoscale technology ; Macroscale technology Reference LTCM-ARTICLE-2007-007View record in Web of Science Record created on 2007-03-22, modified on 2017-05-10
Triple helix–coil transition of covalently bridged collagenlike peptides (1980)

Abstract The thermal triple helix–coil transition of covalently bridged collagenlike peptides with repeating sequences of (Ala‐Gly‐Pro) n , n = 5–15, was studied optically. The peptides were soluble in water/acetic acid (99:1) and were found to form triple‐helical structures in this solvent system beginning with n = 8. The thermodynamic analysis of the transition equilibrium curves for n = 9–13 yielded the parameters Δ H ° s = −7.0 kJ per tripeptide unit, Δ S ° s = −23.1 J deg −1 mol −1 per tripeptide unit for the coil‐to‐helix transition, and the apparent nucleation parameter σ ≃ 5 × 10 −2 . It was suggested through double‐jump temperature experiments that the rate‐limiting step during refolding is not only influenced by the difficulties of nucleation, but also by cis – trans isomerization of the Gly‐Pro peptide bond.
An Integrated Hardware-Software Approach to Task Graph Management (2014)

Task-based parallel programming models with explicit data dependencies, such as OmpSs, are gaining popularity, due to the ease of describing parallel algorithms with complex and irregular dependency patterns. These advantages, however, come at a steep cost of runtime overhead incurred by dynamic dependency resolution. Hardware support for task management has been proposed in previous work as a possible solution. We present VSs, a runtime library for the OmpSs programming model that integrates the Nexus++ hardware task manager, and evaluate the performance of the VSs-Nexus++ system. Experimental results show that applications with fine-grain tasks can achieve speedups of up to 3.4×, while applications optimized for current runtimes attain 1.3×. Providing support for hardware task managers in runtime libraries is therefore a viable approach to improve the performance of OmpSs applications.
Convenient Synthesis of a Simple Coumarin from Salicylaldehyde and Wittig Reagent. II : Synthesis ofBromo- and Methoxycarbonylcoumarins. (1994)

Reaction of salicylaldehydes (1) with carbethoxymethylenetriphenylphosphorane in diethylaniline under reflux gave coumarins (3) in moderate to high yield except 3-methoxycarbonylsalicyladehyde (1e) as summarized in Table I. The substituent effects are discussed. A substituent at C6 on 1 usually facilitated the formation of the coumarin ring regardless of its electronic character.
Syringopeptins, new phytotoxic lipodepsipeptides of <i>Pseudomonas syringae</i> pv. <i>syringae</i> (1991)

The primary structure of some new lipodepsipeptides named syringopeptins, produced by plant pathogenic strains of Pseudomonas syringae pv. syringae has been determined by a combination of chemical methods, 1H and 13C NMR spectroscopy and FAB mass spectrometry. Two syringomycin-producing strains afforded 3-hydroxydecanoyl-Dhb-Pro-Val-Val-Ala-Ala-Val-Val-Dhb-Ala-Val-Ala- Ala-Dhb-aThr-Ser-Ala-Dhb-Ala-Dab-Dab-Tyr, with Tyr acylating a Thr to form a macrolactone ring, and smaller amounts of the 3-hydroxydodecanoyl homologue. Evidence was obtained that a third syringomycin-producing strain and a syringotoxin-producing strain synthesize 3-hydroxydecanoyl-Dhb-Pro-Val-Ala-Ala-Val-Leu-Ala-Ala-Dhb-Val-Dhb- Ala-Val-Ala-Ala-Dhb-aThr-Ser-Ala-Val-Ala-Dab-Dab-Tyr, with Tyr and aThr forming again the macrolactone ring, and smaller amounts of the 3-hydroxydodecanoyl homologue.
Linear Precoding for Multiuser MIMO-OFDM Systems (2007)

This paper develops linear preceding schemes for the downlink in multiuser multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems with multiple data streams per user. We extend an existing multiuser MIMO algorithm, that jointly optimizes the power allocation and the transmit and receive filters, to MIMO- OFDM systems. One extension is to solve the resulting problem of joint power allocation across OFDM subcarriers. This paper also presents efficient methods to reduce the computational load of the algorithm by interpolating the precoding and decoding matrices corresponding to different OFDM subcarriers. The simulations show that the proposed interpolation scheme outperforms previously known schemes, but requires that the precoder for each subcarrier be tailored to the interpolated receiver.
A pattern-based approach to DSL development (2011)

Tool support for the development of Domain-specific Languages (DSLs) is continuously increasing. This reduces implementation effort for DSLs and enables the development of rather complex languages within reasonable amounts of time. However, the lack of commonly agreed and applied language engineering processes, many times turns DSL development into a set of creative activities, whose outcomes depend on the experience of the developers involved. Consequently, outcomes of language engineering activities are unpredictable with respect to their quality, and are often not maintainable either. We have therefore developed an approach that transfers the concept of architecture and design patterns from software engineering to language development. In this paper, we propose this approach and evaluate its applicability in a case study.
Terminal erythroid differentiation in the K-562 cell line by 1-beta-D-arabinofuranosylcytosine: accompaniment by c-myc messenger RNA decrease. (1986)

Two erythroid markers, acetylcholinesterase and hemoglobin, can be reversibly induced in the K-562 cell line after sodium butyrate treatment. In the present paper we show that 1-beta-D-arabinofuranosylcytosine (ara-C), induces the coordinate, irreversible expression of these two erythroid markers. This induction occurs at an ara-C concentration (0.05 mM) that results in K-562 cytostasis and is accompanied by deep morphological changes of cells. The differentiated phenotype is independent of the K-562 cell clone used [K-562, K-562 (S), K-562 (S)P] and is associated with the loss of cell renewal capacity. Continuous presence of the inducer is not necessary to achieve terminal differentiation. In contrast to what is seen for other inducers (sodium butyrate and hemin), one of the early effects of ara-C treatment is the marked decrease of c-myc mRNA expression after the first 4 hours of induction, whereas N-ras and histone 4 expression remain constant during the first 48 h. Our results suggest that ara-C treatment can irreversibly activate the erythroid differentiative program of K-562 cells.
[Antiseptic properties of essential oil of Lippia sidoides Cham. Application to the cutaneous microflora]. (1996)

Two samples of essential oils of Lippia sidoides Cham. have been tested for their antibacterial and antifungal properties against some microorganisms living on the skin of feet and armpits. The essential oils and also their main components, thymol and carvacrol, show strong antagonistic activities. Corynebacterium xerosis developing axillary odour is specially inhibited. But on the other hand no specific activities have been observed upon the feet microflora.
Channel Estimation for OFDM Systems Based on RLS and Superimposed Training Sequences (2007)

The recursive least squares (RLS) algorithm and the superimposed training sequences are applied to the orthogonal frequency division multiplexing (OFDM) systems to estimate channel state information (CSI). In order to reduce the interference caused by the unknown information data that is added with the superimposed training sequences, we present the following method: first, the information data are detected using the CSI of the previous one block, and then subtracted them from the current received signals. Second, the remainder signals mainly including the training sequence are used to estimate CSI. For decreasing the computation complexity, we use the same training sequence in all OFDM blocks. The computation complexity and the mean square error (MSE) performance of our proposed RLS method are compared with the original RLS method.
Keyword Spotting Framework Using Dynamic Background Model (2012)

An important task in Keyword Spotting in handwritten documents is to separate Keywords from Non Keywords. Very often this is achieved by learning a filler or background model. A common method of building a background model is to allow all possible sequences or transitions of characters. However, due to large variation in handwriting styles, allowing all possible sequences of characters as background might result in an increased false reject. A weak background model could result in high false accept. We propose a novel way of learning the background model dynamically. The approach first used in word spotting in speech uses a feature vector of top K local scores per character and top N global scores of matching hypotheses. A two class classifier is learned on these features to classify between Keyword and Non Keyword.
Targeted sequencing using a 47 gene multiple myeloma mutation panel (M<sup>3</sup>P) in ‐17p high risk disease (2014)

We constructed a multiple myeloma (MM)-specific gene panel for targeted sequencing and investigated 72 untreated high-risk (del17p) MM patients. Mutations were identified in 78% of the patients. While the majority of studied genes were mutated at similar frequency to published literature, the prevalence of TP53 mutation was increased (28%) and no mutations were found in FAM46C. This study provides a comprehensive insight into the mutational landscape of del17p high-risk MM. Additionally, our work demonstrates the practical use of a customized sequencing panel, as an easy, cheap and fast approach to characterize the mutational profile of MM.
Large scale visual recommendations from street fashion images (2014)

We describe a completely automated large scale visual recommendation system for fashion. Our focus is to efficiently harness the availability of large quantities of online fashion images and their rich meta-data. Specifically, we propose two classes of data driven models in the Deterministic Fashion Recommenders (DFR) and Stochastic Fashion Recommenders (SFR) for solving this problem. We analyze relative merits and pitfalls of these algorithms through extensive experimentation on a large-scale data set and baseline them against existing ideas from color science. We also illustrate key fashion insights learned through these experiments and show how they can be employed to design better recommendation systems. The industrial applicability of proposed models is in the context of mobile fashion shopping. Finally, we also outline a large-scale annotated data set of fashion images Fashion-136K) that can be exploited for future research in data driven visual fashion.