gebhart/patrepeval huggingface dataset:
Graph Use to Visualize Web Search Results: MyWish 3.0 (2007)

This work suggests a search tool, MyWISH 3.0, as a solution for common web search results visualization limits. This tool unifies performance standards of a stable tool with the advanced visualization ability of a Java-based, highly configurable component. The data flow of these two modules ends up in an XML interface. Moreover, because of its accurate caching techniques and its set-limited activities tracking, the tool aims to be used by communities sharing the same research objectives, making them manage various contents in a easier way. The paper starts with an overview about literature concerning visualization tools, trying to highlight present features and to suggest the deployment of some aspects. Then, it presents a test-case verified and validated implementation within a web search limited background, like a scientific community looking for information concerning European funding.
Theory and Practice of Bloom Filters for Distributed Systems (2011)

Many network solutions and overlay networks utilize probabilistic techniques to reduce information processing and networking costs. This survey article presents a number of frequently used and useful probabilistic techniques. Bloom filters and their variants are of prime importance, and they are heavily used in various distributed systems. This has been reflected in recent research and many new algorithms have been proposed for distributed systems that are either directly or indirectly based on Bloom filters. In this survey, we give an overview of the basic and advanced techniques, reviewing over 20 variants and discussing their application in distributed systems, in particular for caching, peer-to-peer systems, routing and forwarding, and measurement data summarization.
<title>Deep anisotropic ICP plasma etching designed for high-volume MEMS manufacturing</title> (1999)

ICP plasma etching is gaining widespread acceptance as an enabling micromachining technology for advanced MEMS fabrication. Whereas this technology has shown a capability of delivering multiple novel applications for R and D, its acceptance by industry for high volume production has been limited. This acceptance into production will only occur when the plasma etching equipment with this technology offers the device performance, throughput, reliability, and uptime criteria required by a production facility. The design of the plasma etcher using this technology and the process capability it consequently delivers, has significant implications in making this a reality. Alcatel has been supplying such a technology to this MEMS industry for over 5 years and in the interim has evolved its product and process to make this technology production worthy. Alcatel's next generation etcher, the Alcatel 601E, offers multiple advantages to MEMS manufacturers in realizing their production goals.
An auto-configuration of 4M group management using Wireless Sensor Networks for reconfigurable manufacturing system (2009)

The 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> tier of automotive manufacturers has faced to pressures about move, modify, updating tasks for manufacturing resources in production processes from demand response of production order sequence for motor company and process innovation purpose for productivity. For meets this requirements, it has to require absolutely lead time to re-wiring of physical interface for production equipment, needs for change existing program and test over again. For prepare this constraints, it needs studying an auto-configuration functions that build for both visibility and flexibility based on the 4M (Man, Machine, Material, Method) group management which is supports from WSN (Wireless Sensor Network) of the open embedded device called M2M (Machine to Machine) and major functions of middleware including point manager for real time device communication, real time data management, Standard API (Application Program Interface) and application template management. To be application system to RMS (Reconfigurable Manufacturing System) for rapidly response from various orders and model from motor company that is beginning to establishing the mapping of manufacturing resources of 4M using WSN.
Indoor Localization with Low Complexity in Wireless Sensor Networks (2006)

Autonomous localization of nodes in wireless sensor networks is essential to minimize the complex self organization task consequently enhancing the overall network lifetime. Recently, precise indoor localization is impeded by multi path propagation of signals due to reflections at walls or objects. In this paper we partly overcome some of these problems by methods like frequency diversity and averaging multiple measured data. Received radio signal strength (RSS) in combination with weighted centroid localization, featuring low communication overhead and a low complexity of O(n), is our basis of a localization on the energy constrained sensor nodes. We first analyze the RSS-characteristics on a specific sensor node platform in different rooms. Next, we describe methods to improve these characteristics to reach best localization results at minimized complexity. Finally, in a practice indoor localization we achieve a small localization error of only 14% for 69% of all test-points that was enhanced to at least 8% in average by simple optimizations. For that, no hardware modifications as well as time consuming RSSI-maps or complex signal propagation models are required.
Efficient parameter estimation for RNA secondary structure prediction (2007)

Our CG implementation is available at http://www.rnasoft.ca/CG/.
All Copper Interconnection for Chip-to-Package Bonding (2010)

Abstract not Available.
Activities of Daily Living in Behavioral Variant Frontotemporal Dementia (2009)

Patients with the behavioral variant of frontotemporal dementia have marked impairment in everyday life, yet little is known about factors underlying this impairment. Moreover, a recently identified subgroup with normal brain imaging has an excellent prognosis (phenocopy cases) and their performance on activities of daily living (ADL) tasks is unknown. Eighteen behavioral variant frontotemporal dementia patients were assessed on 2 ADL measures, the Disability Assessment for Dementia, a caregiver-based interview, and the Assessment of Motor and Process Skills, a performance-based instrument. Behavior change, global cognition, executive function, and magnetic resonance imaging brain atrophy were also evaluated. There was no association between the 2 ADL measures. A model combining the Addenbrooke's Cognitive Examination Revised (global cognition) and Frontal Systems Behavior Scale (frontal dysfunction) explained the variance on ADL performance. A qualitative rating distinguished between pathologic and phenocopy patients better than the performance-based assessment. Degree of frontal dysfunction and overall dementia determined the level of ADL impairment. The phenocopy patients were clearly distinguishable when evaluated using a performance-based, and even better with a qualitative rating assessment.
Translesion DNA synthesis: polymerase response to altered nucleotides. (1985)

A system for the determination of the specificity of incorporation opposite lesions during DNA synthesis past damaged bases has been used as a model of mutation. The system, based on the dideoxynucleotide sequence method, uses lesions in the template strand as chain terminators. As a first approximation, such lesions constitute non-instructive sites in the DNA. DNA synthesis catalysed by bacteriophage T4 DNA polymerase terminates one nucleotide 3' to the lesion on the template strand. With other polymerases, synthesis may terminate opposite the lesion. The details of termination site depend on the enzyme, the metal ion (Mg2+ or Mn2+), the lesion and the particular nucleotide sequence. The sequence effect for termination on normal templates has two components, one ascribable to secondary structure, the other intrinsic to the sequence itself. DNA molecules terminated before lesions may be used as substrates in 'second stage' reactions in which elongation can be detected on the addition of particular dNTPs (deoxynucleoside triphosphates) to a reaction mixture. The specificity of elongation depends on the polymerase, on the activity of the 3'--greater than 5' editing nuclease and on the particular lesion. DNA polymerases have a preference for the addition of purines, particularly adenine, opposite non-instructional sites. This preference suggests an explanation for the specificity of base substitution mutations: treatments that produce non-instructional sites from purines will lead to transversions, treatments that affect pyrimidines lead to transitions. Even though a base is added opposite a lesion, further elongation may be rate limiting. Whether or not elongation occurs is dependent on the sequence 5' to the lesion on the template strand. The interactions of the factors affecting bypass: polymerase, lesion and sequence, may well result in an idiosyncratic behaviour for each mutable site.
Optimal Response Time Retrieval of Replicated Data. (1994)

This work deals with the problem of finding efficient access plans for retrieving a set of pages from a multi-disk system with replicated data. The paper contains two results related to this problem: (a) We solve the problem of finding an optimal access path by transforming it into a network flow problem. It’e also indicate how our method may be employed in dynamic environments where some (or all) of the disks have a preexisting load, are heterogeneous, and reside on different servers. (b) We present a lower bound for the worst case response time of a request under all replication schemes, and also discuss the replication scheme that results in this lower bound. We then use simulation to show how this replication scheme can also greatly reduce the average case response time.
Wideband differential antenna in package with superstrate structure at 77GHz (2012)

This paper presents a novel antenna in package solution with superstrate structure at 77 GHz for automotive radar applications. Two edge-coupled patches are driven by a differential signal which supports seamless integration with differential output MMICs in a single package. The antenna has a wide bandwidth (17 GHz) and stable gain. The antenna prototypes are fabricated using Embedded Wafer Level Ball Grid Array (eWLB) packaging technology. The measurement results show that the EIRP of the package (chip + antenna) reaches 11 dBm from 75 GHz to 80 GHz. This concept is suitable for a wide area of millimeter-wave front-end applications.
Gene Therapy in Large Animal Models of Muscular Dystrophy (2009)

The muscular dystrophies are a group of genetically and phenotypically heterogeneously inherited diseases characterized by progressive muscle wasting, which can lead to premature death in severe forms such as Duchenne muscular dystrophy (DMD). In many cases they are caused by the absence of proteins that are critical components of the dystrophin-glycoprotein complex, which links the cytoskeleton and the basal lamina. There is no effective treatment for these disorders at present, but several novel strategies for replacing or repairing the defective gene are in development, with early encouraging results from animal models. We review these strategies, which include the use of stem cells of different tissue origins, gene replacement therapies mediated by various viral vectors, and transcript repair treatments using exon skipping strategies. We comment on their advantages and on limitations that must be overcome before successful application to human patients. Our focus is on studies in a clinically relevant large canine model of DMD. Recent advances in the field suggest that effective therapies for muscular dystrophies are on the horizon. Because of the complex nature of these diseases, it may be necessary to combine multiple approaches to achieve a successful treatment.
Cachexia as a major underestimated and unmet medical need: facts and numbers (2010)

Cachexia is a serious, however underestimated and underrecognised medical consequence of malignant cancer, chronic heart failure (CHF), chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), cystic fibrosis, rheumatoid arthritis, Alzheimer's disease, infectious diseases, and many other chronic illnesses. The prevalence of cachexia is high, ranging from 5% to 15% in CHF or COPD to 60% to 80% in advanced cancer. By population prevalence, the most frequent cachexia subtypes are in order: COPD cachexia, cardiac cachexia (in CHF), cancer cachexia, and CKD cachexia. In industrialized countries (North America, Europe, Japan), the overall prevalence of cachexia (due to any disease) is growing and currently about 1%, i.e., about nine million patients. The relative prevalence of cachexia is somewhat less in Asia, but is a growing problem there as well. In absolute terms, cachexia is, in Asia (due to the larger population), as least as big a problem as in the Western world. Cachexia is also a big medical problem in South America and Africa, but data are scarce. A consensus statement recently proposed to diagnose cachexia in chronic diseases when there is weight loss exceeding 5% within the previous 3-12 months combined with symptoms characteristic for cachexia (e.g., fatigue), loss of skeletal muscle and biochemical abnormalities (e.g., anemia or inflammation). Treatment approaches using anabolics, anti-catabolic therapies, appetite stimulants, and nutritional interventions are under development. A more thorough understanding of the pathophysiology of cachexia development and progression is needed that likely will lead to combination therapies being developed. These efforts are greatly needed as presence of cachexia is always associated with high-mortality and poor-symptom status and dismal quality of life. It is thought that in cancer, more than 30% of patients die due to cachexia and more than 50% of patients with cancer die with cachexia being present. In other chronic illnesses, one can estimate that up to 30% of patients die with some degree of cachexia being present. Mortality rates of patients with cachexia range from 10% to 15% per year (COPD), to 20% to 30% per year (CHF, CKD) to 80% in cancer.
Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells. (1987)

The bryostatins are macrocyclic lactones, extracted from the marine bryozoan Bugula neritina, and have been reported to be potent antineoplastic agents. Results described here demonstrate that the bryostatins may also be useful as stimulators of normal human hematopoietic cells since they can (i) directly stimulate bone marrow progenitor cells to form colonies in vitro and (ii) functionally activate neutrophils. Structure-activity studies with bryostatin congeners indicate that these stimulatory properties may be dependent on the chain length and the unsaturated nature of the acylated group at carbons 20 and 7 of the bryostatin molecule. These stimulatory properties demonstrate that the naturally occurring bryostatins can mimic many of the biological effects of multipotential granulocyte-macrophage colony-stimulating factor. Thus, the coupling of antineoplastic activity with stimulatory growth properties for normal hematopoietic cells makes this agent an excellent probe to dissect the mechanism(s) of normal hematopoiesis. In addition, bryostatin may represent a clinically attractive agent useful for treating bone marrow failure states.
Entangled Photon-Pair Two-Dimensional Fluorescence Spectroscopy (EPP-2DFS) (2013)

We introduce a new method, called entangled photon-pair two-dimensional fluorescence spectroscopy (EPP-2DFS), to sensitively probe the nonlinear electronic response of molecular systems. The method incorporates a separated two-photon ('Franson') interferometer, which generates time-frequency-entangled photon pairs, into the framework of a fluorescence-detected 2D optical spectroscopic experiment. The entangled photons are temporally shaped and phase-modulated in the interferometer, and are used to excite a two-photon-absorbing (TPA) sample, whose excited-state population is selectively detected by simultaneously monitoring the sample fluorescence and the exciting fields. In comparison to 'classical' 2DFS techniques, major advantages of this scheme are the suppression of uncorrelated background signals, the enhancement of simultaneous time-and-frequency resolution, the suppression of diagonal 2D spectral features, and the enhancement and narrowing of off-diagonal spectral cross-peaks that contain information about electronic couplings. These effects are a consequence of the pure-state field properties unique to a parametric down-conversion light source, which must be included in the quantum mechanical description of the composite field-molecule system. We numerically simulate the EPP-2DFS observable for the case of an electronically coupled molecular dimer. The EPP-2DFS spectrum is greatly simplified in comparison to its classical 2D counterpart. Our results indicate that EPP-2DFS can provide previously unattainable resolution to extract model Hamiltonian parameters from electronically coupled molecular dimers.
Murine 86- and 84-kDa Heat Shock Proteins, cDNA Sequences, Chromosome Assignments, and Evolutionary Origins (1989)

The two forms of the approximately 90-kDa murine heat shock protein, referred to as HSP86 and HSP84, are coded for by separate but related genes. A full-length nucleotide sequence of the cDNA coding for HSP86 from a chemically induced tumor, Meth A, was determined. Sequences from a number of peptides from HSP86 were found to be in complete agreement with the nucleotide sequence. The HSP84 sequence from the same tumor was also completed. HSP86 and HSP84 are acidic polypeptides 733 and 724 amino acids long with calculated molecular weights of 84,796 and 83,290, respectively. The two proteins are 86% homologous. HSP86 was found to contain internal peptide repeats of Glu-Lys-Glu within a region of highly charged amino acid residues. The coding regions of the cDNAs were 76% homologous; however, this homology did not extend to the 5'- and 3'-untranslated regions. The 5'-untranslated region of hsp86 cDNA was considerably longer than that of hsp84 cDNA and, unlike that of hsp84, contained extraneous ATG triplets. Hsp86-related sequences were assigned to chromosomes 12, 11, and 3. An evolutionary tree constructed from HSP90-related protein sequences indicated that HSP86 and HSP84 were likely to have diverged more than 500 million years ago. The findings presented herein suggest that HSP86 and HSP84 may have different functions.
Cold Starts Using M-85 (85% Methanol): Coping with Low Fuel Volatility and Spark Plug Wetting (1991)

<div class="htmlview paragraph">Spark ignition engines are shown to have difficulty starting on high methanol-content fuels not only because of low fuel volatility but also because of electrical shorting of the ignition by methanol on the spark plugs. Using a concerted approach in which the fuel and ignition systems are optimized for fuel methanol, we have cold started a 2.5L spark ignition engine with port fuel injection down to -29°C on a 10.5 psi Reid vapor pressure M-85 (85% methanol, 15% gasoline). To minimize the amount of spark plug wetting, an exponential decay fuel algorithm is used which quickly generates flammable vapor mixtures while limiting the cylinder wetting. To overcome the spark plug wetting which does occur, ignition systems are used which have peak delivered currents twice as high as present-day automotive inductive ignitions.</div>
OPEN QUESTIONS IN HIGH ENERGY SPIN PHYSICS (2003)

I describe a few of the most exciting open questions in high energy spin physics. After a brief look at (g - 2) μ and the muon electric dipole moment, I concentrate on QCD spin physics. Pressing questions include the interpretation of new asymmetries seen in semi-inclusive DIS, measuring the polarized gluon and quark transversity distributions in the nucleon, testing the DHGHY Sum Rule, measuring the orbital angular momentum in the nucleon, and many others which go beyond the space and time allotted for this talk.
Automatic Classification of Change Requests for Improved IT Service Quality (2011)

Faulty changes to the IT infrastructure can lead to critical system and application outages, and therefore cause serious economical losses. In this paper, we describe a change planning support tool that aims at assisting the change requesters in leveraging aggregated information associated with the change, like past failure reasons or best implementation practices. The thus gained knowledge can be used in the subsequent planning and implementation steps of the change. Optimal matching of change requests with the aggregated information is achieved through the classification of the change request into about 200 fine-grained activities. We propose to automatically classify the incoming change requests using various information retrieval and machine learning techniques. The cost of building the classifiers is reduced by employing active learning techniques or by leveraging labeled features. Historical tickets from two customers were used to empirically assess and compare the accuracy of the different classification approaches (Lucene index, multinomial logistic regression, and generalized expectation criteria).
Proteomic expression analysis of colorectal cancer by two‐dimensional differential gel electrophoresis (2005)

The identification of specific protein markers for colorectal cancer would provide the basis for early diagnosis and detection, as well as clues for understanding the molecular mechanisms governing cancer progression. In this report, we describe the proteomic analysis of the samples of colorectal cancer corresponding to seven patients. We have used the highly sensitive two-dimensional differential gel electrophoresis (2-D DIGE) coupled with mass spectrometry (MS) for the identification of proteins differentially expressed in tumoral and neighboring normal mucosa. We have detected differences in abundance of 52 proteins with statistical variance of the tumor versus normal spot volume ratio within the 95th confidence level (Student's t-test; p < 0.05). Forty-one out of 52 analyzed proteins were unambiguously identified by matrix-assisted laser desorption/ionization-time of flight MS coupled with database interrogation as being differentially expressed in colorectal cancer. An ontology analysis of these proteins revealed that they were mainly involved in regulation of transcription (synovial sarcoma X5 protein, metastasis-associated protein 1), cellular reorganization and cytoskeleton (cytokeratins, vimentin, beta actin), cell communication and signal transduction (annexins IV and V, relaxin, APC), and protein synthesis and folding (heat shock protein 60, calreticulin, cathepsin D, RSP4) among others. Preliminary studies demonstrated that the differentially expressed proteins found by 2-D DIGE could be confirmed and validated by immunoblotting and immunohistochemistry analyses in those few cases where antibodies were available. We believe that the incorporation of more samples and new datasets will permit the definition of a collection of proteins with a potential interest as biomarkers for colorectal cancer.