gebhart/patrepeval huggingface dataset:
Metabolism of Glucose in the Human Endometrium with Special Reference to Fertility and Contraception (1973)

On the basis of numerous biopsy specimens of the endometrium, in which substrates and enzymes concerned in the metabolism of glucose were examined in vitro , the following observations were made. Respiration and redox capacity as well as endogenous and exogenous glycolysis of the endometrium are increased maximally during the secretory phase. In this phase also the absolute Pasteur effect is increased to a maximum, while the control of glycolysis by the substrate is decreased. In addition, a Crabtree‐effect appears at the same time. This suggests that the endometrium in the implantation phase endeavours to deliver constant amounts of ATP and to maintain a stable physico‐chemical environment. While, from a gynaecological point of view various endometrium‐associated disorders cause no notable differences in metabolism, the uptake of glucose, or respiration, cytochrome oxidase and succinate dehydrogenase activity in the secretory endometrium decrease with advancing age and thereby presumably diminish the fertility of the elderly woman. The use of oral contraceptives reduces the glucose metabolism from endogenous and from exogenous substrates in the endometrium, despite increasing synthesis of glycogen during the cycle. The reduction of metabolism occurs to such an extent that it must be expected that a contraceptive effect in the endometrium takes place.
A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules (2015)

Podocyte injury and loss mark an early step in the pathogenesis of various glomerular diseases, making these cells excellent targets for therapeutics. However, cell-based high-throughput screening assays for the rational development of podocyte-directed therapeutics are currently lacking. Here, we describe a novel high-content screening-based phenotypic assay that analyzes thousands of podocytes per assay condition in 96-well plates to quantitatively measure dose-dependent changes in multiple cellular features. Our assay consistently produced a Z' value >0.44, making it suitable for compound screening. On screening with >2100 pharmacologically active agents, we identified 24 small molecules that protected podocytes against injury in vitro (1% hit rate). Among the identified hits, we confirmed an β1-integrin agonist, pyrintegrin, as a podocyte-protective agent. Treatment with pyrintegrin prevented damage-induced decreases in F-actin stress fibers, focal adhesions, and active β1-integrin levels in cultured cells. In vivo, administration of pyrintegrin protected mice from LPS-induced podocyte foot process effacement and proteinuria. Analysis of the murine glomeruli showed that LPS administration reduced the levels of active β1 integrin in the podocytes, which was prevented by cotreatment with pyrintegrin. In rats, pyrintegrin reduced peak proteinuria caused by puromycin aminonucleoside-induced nephropathy. Our findings identify pyrintegrin as a potential therapeutic candidate and show the use of podocyte-based screening assays for identifying novel therapeutics for proteinuric kidney diseases.
ChemInform Abstract: A CONVENIENT PREPARATION OF UNSYMMETRICALLY SUBSTITUTED PYRROLES, FURANS, AND THIOPHENES (1975)

Abstract Aus den Heterocyclen, deren Herstellung beschrieben ist, erhält man nach Umsetzung mit Lithium‐bis‐isopropylamid, Phenylselenylbromid und Wasserstoffperoxid die ent= sprechenden unsymmetrisch substituierten Heterocyclen (II).
A new treatment of the recombination term in the current continuity equations of semi‐conductor device models (1985)

An integral identity is derived by the method of Marchuk for the continuity equation of a carrier current in a semi‐conductor device. The coefficients of this identity are then approximated systematically. The terms involving the discretization of the carrier current turn out to be the same as those in the well known finite difference scheme of Scharfetter and Gummel, while those involving the recombination term are different. It is suggested that this new finite difference scheme will perform significantly better than the Scharfetter‐Gummel scheme especially in regions of the device where the net recombination is sharply peaked.
Raising efficiency of organic solar cells with electrotropic additives (2015)

Incorporation of electrotropic additives with large molecular dipole moments into the bulk heterojunction layer of organic photovoltaic devices followed by electric field poling led to an increase of power conversion efficiency up to 7.97% from 7.17% for devices that did not utilize the additives and from 5.18% for devices with additives prior to poling. The improvement is due to more efficient extraction of photogenerated charge carriers, resulting in higher short circuit current density and fill factor. The observed effects are proposed to arise from a re-orientation of additive molecules in the external electric field, i.e., electrotropism, leading to a macroscopic alignment of their dipole moments. This leads to an increased built-in electrostatic potential difference in the device active layer post-poling. The dependence of device performance on the polarity of poling bias and reversibility of the effect are demonstrated, further supporting the proposed mechanism.
Effect of methylation on the stability of cytochrome c of Saccharomyces cerevisiae in vivo. (1981)

The in vivo stability of methylated and unmethylated cytochrome c in Saccharomyces cerevisiae was studied by pulse-labeling the hemoproteins with [methyl-3H]-methionine and/or [2-14C]methionine and following the fate of these proteins under anaerobiosis and in the presence of cycloleucine. These two conditions will respectively block further cytochrome c synthesis and inhibit methylation by lowering the cellular S-adenosyl-L-methionine pool and, thus, permit an unambiguous interpretation of the data. The results showed that the rate of degradation of unmethylated cytochrome c was constant throughout the chase period, while methylated cytochrome c degradation was seen only in the later part of cold chase. At the end of the chase period (40 h), the extent of degradation of the unmethylated species was three times higher than the methylated species. This indicated that the methylation of cytochrome c has a protective effects against the intracellular proteolytic enzyme attack on itself. Furthermore, this protective effect was considerably reduced in the petite mutant, which lacks high affinity cytochrome c binding sites, functional cytochrome c reductase, and oxidase, and possesses a less integrated and organized mitochondrial membrane. These results led us to the conclusion that the mechanism of methylated cytochrome c stabilization is best explained by a higher efficacy of binding to the mitochondria.
Peanut oil: Compositional data (2010)

Abstract The major fatty acids of peanut oil acylglycerols are palmitic (C16:0), oleic (C18:1), and linoleic (C18:2) acids, and only a trace amount of linolenic fatty acid (C18:3) is present. Thus they have a very convenient oxidative stability and have been considered premium cooking and frying oils. This paper provides information about compositional data of peanut oil taking into account major (triacylglycerols and their fatty acids) and minor (free fatty acids, diacylglycerols, phospholipids, sterols, tocopherols, tocotrienols, triterpenic and aliphatic alcohols, waxes, pigments, phenolic compounds, volatiles, and metals) compounds. Moreover, the influence of genotype, seed maturity, climatic conditions, and growth location on peanut oil chemical composition is considered in the present report. In addition, peanut oils from wild species found in South America as well as from peanut lines developed through conventional breeding are also compared.
Variable-Frequency Bridge-Type Frequency-Stabilized Oscillators (1943)

Results are given of a theoretical and experimental investigation into two types of bridge-stabilized oscillators incorporating a thermal device for amplitude control. One circuit employs only resistances and capacitances in the frequency-determining network and consequently is useful for low-frequency operation. The other circuit uses an inductance-capacitance network which is well adapted to the higher-frequency network. Conditions for optimum stability and the variation of the stability with frequency determined experimentally are found to be in general agreement with theoretical results.
Imaging Tumor Burden in the Brain with <sup>89</sup>Zr-Transferrin (2012)

The results from this study suggest that (89)Zr-transferrin could be a broadly applicable tool for identifying and monitoring tumors in the brain, with realistic potential for near-term clinical translation.
Thin film cadmium telluride and zinc phosphide solar cells (1984)

This report describes research performed from June 1982 to October 1983 on the deposition of cadmium telluride films by direct combination of the cadmium and tellurium vapor on foreign substrates. Nearly stoichiometric p-type cadmium telluride films and arsenic-doped p-type films have been prepared reproducibly. Major efforts were directed to the deposition and characterization of heterojunction window materials, indium tin oxide, fluorine-doped tin oxide, cadmium oxide, and zinc oxide. A number of heterojunction solar cells were prepared, and the best thin-film ITO/CdTe solar cells had an AMl efficiency of about 7.2%. Zinc phosphide films were deposited on W/steel substrates by the reaction of zinc and phosphine in a hydrogen flow. Films without intentional doping had an electrical resistivity on the order of 10/sup 6/ ohm-cm, and this resistivity may be reduced to about 5 x 10/sup 4/ ohm-cm by adding hydrogen chloride or hydrogen bromide to the reaction mixture. Lower resistivity films were deposited by adding a controlled amount of silver nitrate solution on to the substrate surface. Major efforts were directed to the deposition of low-resistivity zinc selenide in order to prepare ZnSe/An/sub 3/P/sub 2/ heterojunction thin-film solar cells. However, zinc selenide films deposited by vacuum evaporation and chemical vapor deposition techniques were all of high resistivity.
High-power multiple-emitter AlGaAs superluminescent diodes (1985)

A superluminescent AlGaAs diode emitting 350 mW of cw optical power at room temperature has been demonstrated for the first time. This extraordinarily high power for nonlasing operation was achieved by combining efficient quantum well material with an edge-emitting, multiple-emitter, short (250 μm) Fabry–Perot cavity incorporating one highly reflective mirror. Lasing action is suppressed by applying a ZrO2 coating with an ultralow reflectivity to the laser’s output facet. Suppression of the lasing in this way produces the uniform and incoherent radiation pattern required for many applications.
ECG signal analysis by pattern comparison (2002)

A new technique for the ECG interpretation by waveform recognition is introduced. The basis for the pattern matching algorithm without feature extraction is an ECG waveform database with ECG signals and patient diagnosis information. The recognition takes place by comparing the waveforms of 12 leads of the examined ECG with the same leads of different ECGs from the database. The similarity of the compared ECG beats is calculated with the cross correlation function. By means of the algorithm, we select ECGs of the database which are the most similar to the examined ECG considering all of the individual leads. Using the available database information, the diagnosis which corresponds to the most similar ECGs of the database is then identified as the diagnosis for the examined ECG. The new method has been tested with 249 original ECGs, most of them from patients with myocardial infarction or from healthy persons.
Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer (2009)

The present study aimed at investigating whether the simultaneous evaluation of pharmacokinetic, pharmacogenetic and demographic factors could improve prediction on toxicity and survival in colorectal cancer patients treated with adjuvant 5-fluorouracil (5FU)/leucovorin therapy. One hundred and thirty consecutive, B2 and C Duke's stage colorectal cancer patients were prospectively enrolled. 5FU pharmacokinetics was evaluated at the first cycle. Thymidylate synthase (TYMS) 5'UTR and 3'UTR polymorphisms and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms were assessed in peripheral leukocytes. Univariate and multivariate analyses were applied to evaluate which variables could predict chemotherapy-induced toxicity, disease-free survival (DFS) and overall survival (OS). Multivariate analysis showed that: (a) low 5FU clearance was an independent predictive factor for severe toxicity (OR=7.32; P<0.0001); (b) high-5FU clearance predicted poorer DFS (HR=1.96; P=0.041) and OS (HR=3.37; P=0.011); (c) advanced age was associated with shorter DFS (HR=3.34; P=0.0008) and OS (HR=2.66; P=0.024); (d) the C/C genotype of the MTHFR C677T polymorphism was protective against grade 3-4 toxicity (P=0.040); (e) none of the TYMS polymorphisms could explain 5FU toxicity or clinical outcome.
Clinical validation of a mandibular movement signal based system for the diagnosis of pediatric sleep apnea (2021)

MM automated analysis shows significant promise to diagnose moderate-to-severe pediatric OSA.
La gestión de la calidad en los servicios de marketing telefónico (1998)

For more than 50 years the exchange lists have been one method of meal planning for persons with diabetes as well as for those on weight-loss regimens. Little research has been conducted, however, concerning the methodologic basis of the system or its clinical effectiveness. Justification for specific food inclusions and general food groupings for the 1995 revision of the Exchange Lists for Meal Planning is provided by a database of foods and associated energy and macronutrient values. The mean energy and macronutrient values for each of the lists and sublists (starch, fruit, milk, and vegetables from the carbohydrate group; the meat and meal substitutes group, and the fat group) closely match the mean exchange values; however, the standard deviation and range are large. Interpretation of the database provides a rationale and guidance for decision making in clinical practice when using exchanges for meal planning, recipe, and food label calculations.
Erfelek İlçe Devlet Hastanesi Evde SağlıkBirimi Hizmetlerinin Değerlendirilmesi (2018)

Ama: almamzda evde salk hizmeti alan hastalarn sosyodemografik verilerini, tanlarn, hastalara sunulan salk hizmetlerini ve bu verilerin birbirleriyle olan ili
Reducing coherence in a fifth-harmonic YAG source (213 nm) for use in microlithography (1991)

The fifth harmonic of the YAG laser represents a possible alternative to the line-narrowed KrF excimer laser for use in deep ultraviolet microlithography. Producing useful amounts of radiation at 213 nm, the fifth-harmonic YAG has a spectral linewidth well within the needs of today’s nearly monochromatic microlithography lenses. This extremely narrow spectral width, combined with nearly single transverse-mode operation, leads to challenging levels of coherence and speckle. Initial measurements of far-field speckle patterns produced by illuminating a diffuser confirm that the speckle contrast is nearly 100%. Rotating the diffuser so that each pulse produced a different speckle pattern would require nearly 10 000 pulses to form an integrated average with 1% rms noise. We have investigated a relatively simple scheme for reducing the speckle contrast produced by a single pulse. This scheme consists of two counter rotating diffusers placed close to each other. It will be shown that for modest rotation speeds (15 K rpm for 100-mm-diam plates) a significant reduction in the single-shot speckle contrast can be achieved. A relation is derived between the noise reduction capabilities of a diffuser and its scattering properties. This relation can be used to predict the maximum speckle reduction possible for a given illumination system numerical aperture.
Precise optical measurement of slider dynamics (1986)

A two beam interferometric technique is used to measure the fluctuations in the flying height of an air bearing slider above a quartz disk. Air bearing variations of less than 0.5 nm are measured from 0 to 100 kHz. Mode excitation is only from disk run out and other sources natural to the rigid disk recording environment. The dynamic behavior of the leading and trailing edges of a slider is shown. Both suspension and air bearing resonant modes are observed at the slider and their frequencies measured.
Synthesis of Trimethylplatinum(IV) Complexes with<i>N,N</i>- and<i>N,O</i>-Heterocyclic Carbene Ligands and Their Reductive C−C Elimination Reactions (2009)

Reactions of the platinum(IV) complexes [PtMe(3)(OCMe(2))(3)](BF(4)) (1(BF(4))), [(PtMe(3)I)(4)] (2), and [PtMe(3)I(py)(2)] (3) with the N,N-heterocyclic carbene 1,3-dimethylimidazol-2-ylidene (N,N-hc, 4) resulted in a rapid reductive elimination of ethane, yielding platinum(II) complexes [PtMe(N,N-hc)(3)](+) (7), trans-[PtMeI(N,N-hc)(2)] (8), and cis-[PtMe(py)(N,N-hc)(2)](+) (10), respectively. Subsequent substitution of the iodo ligand in 8 by pyridine resulted in the formation of trans-[PtMe(py)(N,N-hc)(2)](CF(3)COO) (9(CF(3)COO)). 9 and 10 are stereoisomers. In contrast to this, the analogous reaction of [PtMe(3)(OCMe(2))(3)](BF(4)) (1(BF(4))) with the N,O-heterocyclic carbene 3-methyloxazol-2-ylidene (N,O-hc, 5) was found to yield the tris(carbene)trimethylplatinum(IV) compound [PtMe(3)(N,O-hc)(3)](BF(4)) (12(BF(4))), which is thermally stable up to 218 degrees C in the solid state. Furthermore, reactions of [{PtMe(3)(acac)}(2)] (15) with the N,X-heterocyclic carbenes (X = N, O, S; N,S-hc = 3-methylthiazol-2-ylidene, 6) resulted in the formation of monocarbenetrimethylplatinum(IV) complexes [PtMe(3)(acac)(N,X-hc)] (X = N, 16; X = O, 17; X = S, 18), which were found to be stable against reductive C-C elimination at ambient temperature. Reactions of 16 and 17 with 2,2'-bipyridine (bpy) in the presence of stoichiometric amounts of H(BF(4)) yielded cationic monocarbeneplatinum(IV) complexes, which were isolated as tetrafluoroborate salts [PtMe(3)(bpy)(N,X-hc)](BF(4)) (X = N, 19(BF(4)); X = O, 20(BF(4))). The compounds have been fully characterized analytically and NMR spectroscopically, and for the bis(carbene)platinum(II) compound 9(CF(3)COO) as well as the monocarbeneplatinum(IV) compounds 16 and 20(BF(4)) by single-crystal X-ray diffraction analyses. DFT calculations of mono-, bis-, and tris(carbene)trimethylplatinum(IV) complexes and their propensity to reductive eliminate ethane were performed. In accordance with the experimental findings, a much higher stability of the tris(N,O-hc)- compared with the tris(N,N-hc)trimethylplatinum(IV) complexes against reductive ethane elimination was found, which could be ascribed mainly to a higher steric demand of the N,N-hc ligand.
Enantiomerically pure lactones. 2. Approaches to cis or trans multicyclic lactones (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantiomerically pure lactones. 2. Approaches to cis or trans multicyclic lactonesWilliam H. Pirkle and Paul E. AdamsCite this: J. Org. Chem. 1980, 45, 21, 4111–4117Publication Date (Print):October 1, 1980Publication History Published online1 May 2002Published inissue 1 October 1980https://pubs.acs.org/doi/10.1021/jo01309a008https://doi.org/10.1021/jo01309a008research-articleACS PublicationsRequest reuse permissionsArticle Views564Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress (1986)

The activities of the hexose monophosphate pathway enzymes glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were measured at autopsy in control and Alzheimer's disease brains. Enzyme activities did not vary between different areas of brain and were unaltered by age. In Alzheimer's disease, the activities of both enzymes were increased, the glucose-6-phosphate dehydrogenase activity being almost double the activity of normal controls. We propose that this increased enzyme activity is a response to elevated brain peroxide metabolism.
El rompecabezas monetario y financiero cubano (2010)

La crisis de la balanza de pagos en 2008-2009 y un grupo de errores de politica economica han generado nuevas complicaciones monetarias y financieras en la economia cubana, que se anaden a los costes y distorsiones de la dualidad monetaria.

Actualmente la economia cubana opera con dos monedas locales –peso cubano y peso convertible, ambas con problemas de convertibilidad, y con tipos de cambios multiples y sobrevaluados– y desde 2009 sufre una crisis bancaria. Es un verdadero rompecabezas monetario y financiero. Para poder eliminar la doble moneda y superar los desequilibrios financieros, la politica monetaria necesita devaluar las dos monedas domesticas. Los bancos cubanos se encuentran en una crisis de liquidez sistemica sin un prestamista de ultima instancia que les ayude a sobrepasarla. El pais no puede contar con un prestamo de ultima instancia desde el FMI, Banco Mundial o el BID por no ser miembro de estas instituciones. El gobierno viene aplicando una fuerte politica de ajuste que ha permitido reducir el deficit fiscal y disponer de un superavit en la balanza de pagos, con el cual se empezaron a pagar deudas y a descongelar gradualmente cuentas bancarias, aunque todavia el asunto esta lejos de resolverse completamente.
Challenge and conventionality in the fiction of E.M. Forster (1991)

This is a study of plot-structure and characterization in the novels and short stories of E.M. Forster that aims to bring out certain unique and distinctive features of his fiction. It examines recurring patterns of events and personal relationships which, it is argued, are significantly present in all of Forster's major fiction and in most of his survivng short stories. After an introduction that looks particularly at recurring character-types in Forster's stories, the study examines his fictional writings in chronological order of composition. What emerges is not only the repeated use of certain fictional patterns, but also observations on specific ways in which Forster grew and developed as a novelist. In drawing these observations together, the conclusion attempts to place Forster in relation to some of the main traditions of English fiction.