gebhart/patrepeval huggingface dataset:
Comprehensive Thermodynamic Characterization of the Metal−Hydrogen Bond in a Series of Cobalt-Hydride Complexes (2002)

A detailed structural and thermodynamic study of a series of cobalt-hydride complexes is reported. This includes structural studies of [H(2)Co(dppe)(2)](+), HCo(dppe)(2), [HCo(dppe)(2)(CH(3)CN)](+), and [Co(dppe)(2)(CH(3)CN)](2+), where dppe = bis(diphenylphosphino)ethane. Equilibrium measurements are reported for one hydride- and two proton-transfer reactions. These measurements and the determinations of various electrochemical potentials were used to determine 11 of 12 possible homolytic and heterolytic solution Co-H bond dissociation free energies of [H(2)Co(dppe)(2)](+) and its monohydride derivatives. These values provide a useful framework for understanding observed and potential reactions of these complexes. These reactions include the disproportionation of [HCo(dppe)(2)](+) to form [Co(dppe)(2)](+) and [H(2)Co(dppe)(2)](+), the reaction of [Co(dppe)(2)](+) with H(2), the protonation and deprotonation reactions of the various hydride species, and the relative ability of the hydride complexes to act as hydride donors.
The Human Organization (1997)

The Human Organization is a response to the network morphology. As networks supersede hierarchy as the predominant form of organization, fluid processes and flexible teams need to replace fixed reporting lines and familiar functions. The barriers to achieving this are more often cultural and emotional than they are commercial and technological. This paper proposes that effective knowledge‐based businesses will be built on human network connections. This requires much greater investment in social processes of integration and in our individual ability to connect with each other. Without this human agenda, the openness and learning on which the generative knowledge‐based environment depends will remain beyond our reach, together with our ability to work and transfer knowledge across complex and shifting organizational boundaries.
All-in-one graphene fiber supercapacitor (2014)

A flexible all-in-one single fiber supercapacitor has been fabricated through region-specific reduction of graphene oxide (GO) fiber by laser irradiation, and thus reduced GO layers as electrodes and GO as the separator are integrated into one single fiber. This in-fiber supercapacitor with high mechanical flexibility and high performance could be woven into the textile for wearable electronics and beyond.
Accelerating Adobe Photoshop with reconfigurable logic (2002)

This paper presents the results of a project designed to produce a commercial application for reconfigurable logic. We describe how we took the popular image processing application Adobe Photoshop and used its plug-in technology to devise a set of FPGA-based filters to accelerate colour space conversion and image convolution operations. Some of the barriers that make it difficult to produce portable FPGA-based filters are explored.
Partial nephrectomy for renal cell carcinoma with a normal opposite kidney (1994)

Complete local excision of the small serendipitous renal tumor is feasible and reasonable in the patient with an otherwise normal opposite kidney.
A pyridine nucleotide-independent aldehyde dehydrogenase involved in the alkane oxidation of 'Acetobacter rancens' (1984)

The strain 'Acetobacter rancens' CCM1774 was investigated concerning the occurrence of aldehyde dehydrogenases after growth on different carbon sources.Two constitutive enzyme activities, a NADP+-dependent one and a pyridine nucleotide-independent one, have been detected.The catalytic properties of the latter membrane-bound aldehyde dehydrogenase suggest its participation in the degradation of long-chain n-alkanes.
ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer’s Disease in Mouse Models (2015)

Degeneration of basal forebrain cholinergic neurons (BFCNs) is associated with cognitive impairments of Alzheimer's disease (AD), implying that BFCNs hold potentials in exploring stem cell-based replacement therapy for AD. However, studies on derivation of BFCNs from embryonic stem cells (ESCs) are limited, and the application of ESC-derived BFCNs remains to be determined. Here, we report on differentiation approaches for directing both mouse and human ESCs into mature BFCNs. These ESC-derived BFCNs exhibit features similar to those of their in vivo counterparts and acquire appropriate functional properties. After transplantation into the basal forebrain of AD model mice, ESC-derived BFCN progenitors predominantly differentiate into mature cholinergic neurons that functionally integrate into the endogenous basal forebrain cholinergic projection system. The AD mice grafted with mouse or human BFCNs exhibit improvements in learning and memory performances. Our findings suggest a promising perspective of ESC-derived BFCNs in the development of stem cell-based therapies for treatment of AD.
Critical Thickness for the Si<sub>1-x</sub>Ge<sub>x</sub>/Si Heterostructure (1990)

An energy balance theory for predicting the critical thickness of the Si 1- x Ge x /Si heterostructure is derived based on an experimentally identified dislocation generation mechanism. The theory is in close agreement with experimental results. The critical thickness predicted by this theory is about four times that by the mechanical balance theory of Matthews and Blakeslee.
XIV.—The decomposition of ammonia by heat (1884)

W. Ramsay and S. Young, J. Chem. Soc., Trans., 1884, 45, 88 DOI: 10.1039/CT8844500088
[Metabolic transformations of the trimethyl - 3,5,5, cyclohexene-2, one-1 (isophorone) (author's transl)]. (1978)

In the rabbit, isophorone alpha is partly eliminated, unchanged in the expired air and in the urine and, for another part, metabolized in the organism and excreted in the urine. The metabolites which have been characterized are : dimethyl-5,5, cyclohexen-1, one-3, carboxylic-1 acid, deriving from isophorone by methyloxidation, isophorol (trimethyl-3,5,5 cyclohexen-2, ol-1) formed by the reduction of the ketonic group into a secondary alcohol and eliminated as a glucuronide, dihydroisophorone (trimethyl-3,5,5, cyclohexanone) proceeding from the hydrogenation of the cyclohexen cycle and cis and trans trimethyl-3,5,5, cyclohexanols-1. These latter compounds, found in small quantities, are very likely issued from dihydroisophorone which is transformed in the organism into isophorone alpha and cis and trans trimethyl-3,5,5, cyclohexanols-1, according to a process of dismutation.
Scaling laws for MEMS mirror-rotation optical cross connect switches (2002)

The design of large-scale mirror-rotation free-space optical cross-connect switches based on arrays of microelectromechanical torsion mirrors is considered. The layout of a compact switch is first presented. The parameters of the Gaussian beam that maximizes the port count for a given mirror turn angle is then identified, and the supporting optical system needed to create the desired beam is defined. Scaling laws for the optical path length needed for a given number of ports are then derived. Numerical simulations are used to verify the ideal configuration, and scaling laws are proposed for various departures from the ideal. It is shown that ideal operation can still be maintained when the mirrors are curved, and operating conditions that minimize the effect of mirror curvature are identified.
Ultrasonic characterization of a polymerizing epoxy resin with imbalanced stoichiometry (1996)

The effect of the mixing ratio of curing agent to epoxy prepolymer on the isothermal polymerization of common epoxy systems has been characterized by ultrasonic spectroscopy. During polymerization, changes in longitudinal ultrasonic wave properties (velocity and attenuation) were observed. These changes were related to the glass transition temperature of the resins. The profile of velocity and attenuation clearly depended on the mixing ratio. In all resins, the wave attenuation exhibited a peak in the primary relaxation (α).
ChemInform Abstract: 2‐METHYLENE‐1,3‐INDANDIONES: AZAAROMATIC ANTICOAGULANTS WITHOUT ENOLIZABILE FUNCTIONS (1984)

Abstract Die aus Indandion (I) durch Aldolkondensation mit azaaromatischen Aldehyden (II) hergestellten ungesättigten Diketone (III) werden auf ihre Wirksamkeit als Antikoa ulantien geprüft.
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. (1981)

Mouse thymidine kinase-negative (TK-) L cells were transformed with concatenates of cloned herpes simplex virus 1 TK DNA and different rabbit beta-globin DNAs in which the globin genes were preceded by native flanking sequences of 14, 66, 76, 425, and 1500 nucleotides.l In all cases, selection for TK+ cell lines led to a high yield of lines producing 5-1500 mature rabbit beta-globin-specific RNA strands per cell. The 5' termini of the transcripts mapped to (i) the "cap" nucleotide, (ii) positions 42 to 48 nucleotides downstream from the cap site, or (iii) positions in the vector DNA preceding the gene. In the case of the gene with only 14 base pairs of 5' flanking sequence, a high level of rabbit beta-globin RNA was produced, but none of the transcripts had the correct 5' end; most of them originated in the vector moiety. With 66 base pairs of 5' flanking sequence, 5% of the 5' termini were correct, and with 76 or more base pairs, 30-85% were correct. The region between 14 and 66 base pairs preceding the cap site contains the Hogness box and appears to be essential for correct initiation of transcription. The region between 66 and 76 base pairs before the cap site contains a variant of the canonical sequence G-G-C-T-C-A-A-T-C-T found preceding many other genes at a similar location, and this region may modulate the efficiency of transcription. The sequence of 425 nucleotides preceding the rabbit beta-globin gene is reported.
Seasonal variations in heterotrophic bacterial populations in waters off Sydney (1964)

Viable counts were made of heterotrophic bacteria in seawater samples taken from 0, 25, 50, 75, and 100 m at one station off Sydney over a period of 2 years. Populations, which fell largely within the range of 10-1000/ml, tended to be higher in spring and early summer than at other times. Some evidence was obtained of a negative correlation between bacterial population and chlorinity. There was no evidence of a correlation between bacterial populations and several other variables which were examined. A (presumed) species of Chromobacterium occurred intermittently at the lower depths with some suggestion of a correlation with season and total bacterial count.
1.55-μm Ce,Er:ZBLAN fiber laser operation under 980-nm pumping: experiment and simulation (2002)

Fiber laser operating property at 1.55-μm band in a newly developed Ce,Er:ZBLAN fiber by a continuous-wave laser diode pumping at 980 nm is presented. The output characteristics of the Ce,Er:ZBLAN fiber laser system are analyzed in detail based on the rate equations model by taking into account the energy transfer between Ce/sup 3+/ and Er/sup 3+/ ions, as well as the upconversion mechanisms. The promotion role of the Ce in the erbium-doped ZBLAN for the 1.55-μm band fiber laser operation has been realized.
Enhanced delineation of reservoir compartmentalization from advanced preand post-stack seismic attribute analysis (2014)

Abstract Clark Chahine, Leigh Truelove and Mauricio Herrera Volcan propose a new approach to preconditioning steps designed to avoid degradation of data.
Small interfering RNAs containing full 2′-<i>O</i>-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity (2005)

RNA interference (RNAi) is a process by which short interfering RNAs (siRNAs) direct the degradation of complementary single-strand RNAs. In this study, we investigated the effects of full-strand phosphorothioate (PS) backbone and 2'-O-methyl (2'-OMe) sugar modifications on RNAi-mediated silencing. In contrast to previous reports, we have identified active siRNA duplexes containing full 2'-OMe-modified sense strands that display comparable activity to the unmodified analog of similar sequence. The structure of these modified siRNAs is the predominant determinant of their activity, with sequence and backbone composition being secondary. We further show, by using biotin-tagged siRNAs and affinity-tagged hAgo2/eIF2C2, that activity of siRNA duplexes containing full 2'-OMe substitutions in the sense strand is mediated by the RNA-induced silencing complex (RISC) and that strand-specific loading (or binding) to hAgo2 may be modulated through selective incorporation of these modifications.
Relationship between insulin resistance, insulin secretion and insulin metabolism in simple obesity. (1985)

The study was designed to evaluate whether the correlation occurring in simple obesity between insulin resistance and peripheral hyperinsulinemia corresponds to a relationship between insulin resistance and insulin overproduction by the pancreas. In addition, the study investigated the relation existing in simple obesity between insulin resistance and insulin metabolism. For these purposes, we measured and correlated: (1) insulin sensitivity, estimated by glucose disappearance rate from plasma after intravenous insulin injection; (2) insulin secretion by the pancreas, estimated by fasting C-peptide levels in peripheral blood; (3) insulin metabolism, estimated by means of C-peptide: insulin molar ratio in peripheral blood. Twenty-five subjects (20 females, five males) aged 21 to 59 years were studied. All were obese and had a normal glucose tolerance. Glucose disappearance rate from plasma after i.v. insulin injection averaged 3.65 +/- 0.42 mg/dl/min (mean +/- s.e.m.). Fasting C-peptide was 0.90 +/- 0.09 nmol/l. Fasting C-peptide: insulin molar ratio averaged 5.94 +/- 0.48. Negative correlations were found between glucose disappearance rates after i.v. insulin injection, ie, insulin sensitivity, and fasting concentrations of both insulin (r = -0.806, P less than 0.001) and C-peptide (r = -0.525, P less than 0.01). A positive relationship was found between glucose disappearance rate from plasma after i.v. insulin injection and fasting C-peptide: insulin molar ratio, ie, insulin metabolism (r = 0.707, P less than 0.001). We conclude that in simple obesity insulin overproduction by the pancreas is negatively related to insulin resistance, and insulin resistance and impaired insulin metabolism are strictly related phenomena.
Analog CMOS deterministic Boltzmann circuits (1993)

CMOS circuits implementing an analog neural network (ANN) with on-chip deterministic Boltzmann learning (DBL) and capacitive synaptic weight storage have been designed, fabricated, and tested. Weights are refreshed by periodic repetition of the training data. The circuits were used to build a 12-neuron, 132-synapse ANN that performed well in a variety of learning experiments, including a 36-input to 4-output mapping problem. Adaptive systems such as those described here can compensate for imperfections in the components from which they are constructed and therefore can be built using simple silicon area-efficient analog circuits. The test results indicate that deterministic Boltzmann ANNs can be implemented efficiently using analog CMOS circuitry.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Novel nuclear localization signal between the two DNA‐binding zinc fingers in the human vitamin D receptor (1998)

The human vitamin D receptor (hVDR) possesses a unique array of five basic amino acids positioned between the two DNA-binding zinc fingers that is similar to well-characterized nuclear localization sequences in other proteins. When residues within this region are mutated to nonbasic amino acids, or when this domain is deleted, the receptor is still well expressed, but it no longer associates with the vitamin D-responsive element in DNA, in vitro, and hVDR-mediated transcriptional activation is abolished in transfected cells. Concomitantly, the mutated hVDRs exhibit a significant shift in hVDR cellular distribution favoring cytoplasmic over nuclear retention as assessed by subcellular fractionation and immunoblotting. Independent immunocytochemical studies employing a VDR-specific monoclonal antibody demonstrate that mutation or deletion of this basic domain dramatically attenuates hVDR nuclear localization in transfected COS-7 cells. Although wild-type hVDR is partitioned predominantly to the nucleus in the absence of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) hormone, treatment with ligand further enhances nuclear translocation, as it does to some degree in receptors with the basic region altered. The role of 1,25(OH)2D3may be to facilitate hVDR heterodimerization with retinoid X receptors, stimulating subsequent DNA binding and ultimately enhancing nuclear retention. Taken together, these data reveal that the region of hVDR between Arg-49 and Lys-55 contains a novel constitutive nuclear localization signal, RRSMKRK. J. Cell. Biochem. 70:94-109, 1998. © 1998 Wiley-Liss, Inc.
Hunter−Killer Peptide (HKP) for Targeted Therapy (2008)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Hunter−Killer Peptide (HKP) for Targeted TherapyH. Michael Ellerby†, Dale E. Bredesen‡, Satoshi Fujimura‡, and Varghese John*‡View Author Information College of Pharmacy, Touro University, 1310 Johnson Lane, Mare Island, Vallejo, California 94592, and Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945* To whom correspondence should be addressed. Phone: (415) 493-3651. Fax: (415) 209-2230. E-mail: [email protected]†Touro University.‡Buck Institute for Age Research.Cite this: J. Med. Chem. 2008, 51, 19, 5887–5892Publication Date (Web):August 23, 2008Publication History Received29 April 2008Published online23 August 2008Published inissue 9 October 2008https://pubs.acs.org/doi/10.1021/jm800495uhttps://doi.org/10.1021/jm800495ureview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views1254Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Cells,Membranes,Peptides and proteins,Rodent models Get e-Alerts
Human Bone Marrow Adipocytes Block Granulopoiesis Through Neuropilin-1-Induced Granulocyte Colony-Stimulating Factor Inhibition (2008)

Adipocytes are part of hematopoietic microenvironment, even though up to now in humans, their role in hematopoiesis is still questioned. We have previously shown that accumulation of fat cells in femoral bone marrow (BM) coincides with increased expression of neuropilin-1 (NP-1), while it is weakly expressed in hematopoietic iliac crest BM. Starting from this observation, we postulated that adipocytes might exert a negative effect on hematopoiesis mediated through NP-1. To test this hypothesis, we set up BM adipocytes differentiated into fibroblast-like fat cells (FLFC), which share the major characteristics of primitive unilocular fat cells, as an experimental model. As expected, FLFCs constitutively produced macrophage colony stimulating factor and induced CD34(+) differentiation into macrophages independently of cell-to-cell contact. By contrast, granulopoiesis was hampered by cell-to-cell contact but could be restored in transwell culture conditions, together with granulocyte colony stimulating factor production. Both functions were also recovered when FLFCs cultured in contact with CD34(+) cells were treated with an antibody neutralizing NP-1, which proved its critical implication in contact inhibition. An inflammatory cytokine such as interleukin-1 beta or dexamethasone modulates FLFC properties to restore granulopoiesis. Our data provide the first evidence that primary adipocytes exert regulatory functions during hematopoiesis that might be implicated in some pathological processes. Disclosure of potential conflicts of interest is found at the end of this article.
Low-cost back contact silicon solar cells (1999)

Back-contacted solar cells offer multiple advantages in regard of reducing module assembling costs and avoiding grid shadowing losses. The investigated emitter-wrap-through (EWT) device design has an electrical connection of the front emitter and the rear emitter grid in form of small holes drilled into the crystalline silicon wafer. The obtained cell structure is especially suitable for low-cost base material with small minority carrier diffusion lengths. Different industrially applicable solar cell manufacturing processes for EWT devices are described and compared. The latest experimental results are presented and interpreted; the photocurrent is found to be distinctly increased. The relation between open circuit voltage and rear side passivation is discussed based on two-dimensional (2-D) computer simulations.
Combustion instabilities in liquid-fuelled propulsion systems (1988)

Combustion of reactants in a confined volume favors excitation of unsteady motions over a broad range of\nfrequencies. A relatively small conversion of the energy released will produce both random fluctuations or noise,\nand, under many circumstances, organized oscillations generically called combustion instabilities. Owing to the\nhigh energy densities and low losses in combustion chambers designed for propulsion systems, the likelihood of\ncombustion instabilities is high. The accompanying heat transfer to exposed surfaces, and structural vibrations\nare often unacceptable, causing failure in extreme cases. This paper is a brief review of combustion instabilities in\nliquid-fueled propulsion systems-rockets, ramjets, and thrust augmentors-with emphasis on work accomplished\nduring the past decade. To provide a common framework for discussing the wide range of works, a theory of\ntwo-phase flow is reviewed as the basis for an approximate analysis of combustion instabilities. The analysis is\ndirected primarily to treatment of linear stability; it is sufficiently general to accommodate all processes occurring\nin actual systems. A new result has been obtained for an extended form of Rayleigh's criterion and its relation\nto the growth constant for unstable waves. The chief mechanisms for combustion instabilities in liquid-fueled\nsystems are reviewed, followed by a summary of the common methods of analysis and applications to the three\nclasses of propulsion systems. Control of instabilities by passive and active means is examined briefly.