gebhart/patrepeval huggingface dataset:
Atmospheric pressure barrier discharge deposition of silica-like films on polymeric substrates (2006)

Silica-like coatings were deposited on polymer foils in APG discharge in a roll-to-roll configuration. The dependence of film structure and chemical composition on the conditions during deposition process was studied by means of SEM, ATR-FTIR, and XPS analysis. The influence of oxidant concentration on the deposited film properties is analyzed and discussed. It was observed that pulsing of the APG discharge suppresses dust formation in atmospheric plasma and, therefore, provides uniform coatings.
Implantation failure: molecular mechanisms and clinical treatment (2010)

Optimizing endometrial receptivity in fertility treatment will improve success rates. Evaluation of implantation markers may help to predict pregnancy outcome and detect occult implantation deficiency. Treating the underlying gynecological disease with medical or surgical interventions is the optimal current therapy. Manipulating the expression of key endometrial genes with gene or stem cell-based therapies may some day be used to further improve implantation rates.
Evidence that photoactivated pheophorbide a causes in human cancer cells a photodynamic effect involving lipid peroxidation (2009)

Photodynamic therapy (PDT) is a treatment modality that uses a combination of a photosensitizer and light to induce a photokilling process in the tumor tissue. Recently we re-considered pheophorbide a (Pba), a second-generation photosensitizer that has not yet been thoroughly investigated. Here, we report that Pba irradiated at 14 J/cm(2) induces a strong photodynamic effect in four tumor cell lines, with IC(50) values ranging between 70 and 250 nM. The mechanism of phototoxicity has been investigated in HeLa (IC(50) = 150 nM) and HepG2 (IC(50) = 95 nM) cells. In both cell lines Pba induces lipid peroxidation, as indicated by a marked increase of malonyldialdehyde and oxidized C11 BODIPY(581/591). At high doses (>IC(50)), Pba arrests cell growth completely by activating apoptosis and/or necrosis, while at low doses (<IC(50)), the photosensitizer causes a temporary growth arrest. In the presence of Pba photodamage, the cells activate a protective mechanism against oxidative stress mediated by a strong increase of heme oxygenase-1 expression (up to 12-fold in HepG2 and 25-fold in HeLa). Moreover, considering that GSTA1-1 is a response gene to lipid peroxidation, we treated with Pba a genetically modified HepG2 clone, in which GSTA1-1 was constitutively silenced by siRNA, observing a 25% increase of lipid peroxidation as compared to HepG2 clone expressing GSTA1-1. These data suggest that combine treatments in which Pba is used with gene-silencing molecules against HO-1 and GSTA1-1 should potentiate PDT.
The Solar System (2000)

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Epigenetic Silencing of Tumor Necrosis Factor α during Endotoxin Tolerance (2007)

Sustained silencing of potentially autotoxic acute proinflammatory genes like tumor necrosis factor alpha (TNFalpha) occurs in circulating leukocytes following the early phase of severe systemic inflammation. Aspects of this gene reprogramming suggest the involvement of epigenetic processes. We used THP-1 human promonocytes, which mimic gene silencing when rendered endotoxin-tolerant in vitro, to test whether TNFalpha proximal promoter nucleosomes and transcription factors adapt to an activation-specific profile by developing characteristic chromatin-based silencing marks. We found increased TNFalpha mRNA levels in endotoxin-responsive cells that was preceded by dissociation of heterochromatin-binding protein 1alpha, demethylation of nucleosomal histone H3 lysine 9 (H3(Lys(9))), increased phosphorylation of the adjacent serine 10 (H3(Ser(10))), and recruitment of NF-kappaB RelA/p65 to the TNFalpha promoter. In contrast, endotoxin-tolerant cells repressed production of TNFalpha mRNA, retained binding of heterochromatin-binding protein 1alpha, sustained methylation of H3(Lys(9)), reduced phosphorylation of H3(Ser(10)), and showed diminished binding of NF-kappaB RelA/p65 to the TNFalpha promoter. Similar levels of NF-kappaB p50 occurred at the TNFalpha promoter in the basal state, during active transcription, and in the silenced phenotype. RelB, which acts as a repressor of TNFalpha transcription, remained bound to the promoter during silencing. These results support an immunodeficiency paradigm where epigenetic changes at the promoter of acute proinflammatory genes mediate their repression during the late phase of severe systemic inflammation.
Learning to analyze binary computer code (2008)

We present a novel application of structured classification: identifying function entry points (FEPs, the starting byte of each function) in program binaries. Such identification is the crucial first step in analyzing many malicious, commercial and legacy software, which lack full symbol information that specifies FEPs. Existing pattern-matching FEP detection techniques are insufficient due to variable instruction sequences introduced by compiler and link-time optimizations. We formulate the FEP identification problem as structured classification using Conditional Random Fields. Our Conditional Random Fields incorporate both idiom features to represent the sequence of instructions surrounding FEPs, and control flow structure features to represent the interaction among FEPs. These features allow us to jointly label all FEPs in the binary. We perform feature selection and present an approximate inference method for massive program binaries. We evaluate our models on a large set of real-world test binaries, showing that our models dramatically outperform two existing, standard disassemblers.
Selection-Driven Immune Escape Is Not A Significant Factor in the Failure of Cd4 T Cell Responses in Persistent Hepatitis C Virus Infection (2009)

Apparent mutational escape can occur in MHC class II-restricted epitopes, but this is uncommon when compared with class I-restricted epitopes in the same individual. This indicates that other mechanisms for silencing CD4 T cells are dominant in persistent HCV infections.
Explaining the increasing incidence of differentiated thyroid cancer (2007)

The thyroid is the largest of the endocrine glands and by far the most common site of all primary endocrine cancers. However, thyroid cancer is relatively rare, accounting for only 1% of all cancers. The number of new cases diagnosed each year is comparable to that of leukemia, pancreatic cancer and
Restoration of fibroblast growth factor receptor2 suppresses growth and tumorigenicity of malignant human prostate carcinoma PC‐3 cells (2004)

The results indicate that restoration of FGFR2IIIb to the malignant human prostate epithelial cell prototype PC-3 restores properties associated with nonmalignant tumors and normal cells. This further suggests that epithelial cell resident, homeostasis-promoting FGFR2 may be involved in suppression of malignancy and that restoration may be a candidate for gene therapy of hormone-refractory prostate cancer.
Molecular cloning and sequence analysis of human preprocathepsin C (1995)

A cDNA clone (C1) coding for human preprocathepsin C was isolated from a human ileum cDNA library using a rat kidney-derived RT-PCR probe and its complete nucleotide sequence determined. The full-length 1857 bp sequence codes for a protein of 463 amino acid residues with a calculated molecular mass of 51848 Da. Comparison of the deduced amino acid sequence with that of rat preprocathepsin C indicates an 87.5% identity. A multiple alignment of the deduced cathepsin C sequence of 233 residues which, by analogy to other cystein proteinases, corresponds to the mature protein, confirms that human cathepsin C belongs to the papain superfamily.
Adaptive communication filtering (1962)

This paper reports the results of a study of adaptive communication filtering. It is assumed that either the noise or the signal is completely unknown and only the spectrum or autocorrelation function of the other is known. it is desired to filter according to a mean-square error criteria. Several adaptive filters were investigated, and the two found practical are described here in detail. Both may be realized pnysically by the use of tapped delay lines, or they may be constructed as part of a digital computer program. On the computer they are capable of real-time filtering of many types of signals. Measurements taken of signal and noise give the information needed to adJust-- ia a straightforward manner--the filter parameters. The parameters will converge with time to give the optimum filter. Also described is a technique external to the adaptive filter for greatly increasing the useable frequency range when filtering a narrow-band signal.
Evaluation of epoxy resin formulations for SF6 cable spacer materials (1978)

Research is underway at IREQ on the insulation performance of compressed SF <sub>6</sub> insulated cables for power transmission at system voltages up to 800 kV. The work reported here is concerned with the choice of materials for the design and testing of model size and full size spacers for 138 kV and 800 kV system voltage respectively. Five epoxy resin formulations were considered together with the effect of the filler. The electrical evaluation of the materials included the study of surface properties such as dry are resistance and tracking and erosion resistance and volume properties such as dielectric losses, permittivity and dielectric strength with point to plane geometry. The mechanical impact resistance was measured. Thermal measurements consisted in the evaluation of the heat distorsion temperature and the coefficient of thermal expansion. The test results and the usefulness of the tests with respect to the judicious choice of spacer dielectric materials are discussed.
Innovations in Gastro-Intestinal Endoscopy: Endoscopic Antireflux Therapies for Gastro-Oesophageal Reflux Disease (2002)

Endoscopic antireflux therapies have the potential to treat patients with GORD. However, further studies are necessary to determine what modifications to these techniques are required in order to produce the maximum clinical efficacy and durability.
Moldable clay-like unit for synthesis of highly elastic polydimethylsiloxane sponge with nanofiller modification (2017)

A clay-like unit is beneficial for the moldable synthesis of a superelastic polydimethylsiloxane sponge with nanofiller modification <italic>via</italic> an ultrasound-assisted <italic>in situ</italic> polymerization approach.
The diagnosis of hypertrophic cardiomyopathy by cardiovascular magnetic resonance (2012)

Hypertrophic cardiomyopathy (HCM) is the most common genetic disease of the heart. HCM is characterized by a wide range of clinical expression, ranging from asymptomatic mutation carriers to sudden cardiac death as the first manifestation of the disease. Over 1000 mutations have been identified, classically in genes encoding sarcomeric proteins. Noninvasive imaging is central to the diagnosis of HCM and cardiovascular magnetic resonance (CMR) is increasingly used to characterize morphologic, functional and tissue abnormalities associated with HCM. The purpose of this review is to provide an overview of the clinical, pathological and imaging features relevant to understanding the diagnosis of HCM. The early and overt phenotypic expression of disease that may be identified by CMR is reviewed. Diastolic dysfunction may be an early marker of the disease, present in mutation carriers prior to the development of left ventricular hypertrophy (LVH). Late gadolinium enhancement by CMR is present in approximately 60% of HCM patients with LVH and may provide novel information regarding risk stratification in HCM. It is likely that integrating genetic advances with enhanced phenotypic characterization of HCM with novel CMR techniques will importantly improve our understanding of this complex disease.
Codrugs (2007)

INTRODUCTION Topical analgesic and anti-inflammatory therapy aims to (1) relieve pain; (2) reduce the clinical signs of inflammation (edema, loss of function, etc.) whether local (e.g., dermatitis) or distal (e.g., synovitis); and (3) facilitate healing. A drug (or placebo) is accepted as useful if symptoms are controlled without impairing healing or inducing other toxicities.
An Enzyme Cascade Synthesis of Vanillin (2019)

A novel approach for the synthesis of vanillin employing a three-step two-enzymatic cascade sequence is reported. Cytochrome P450 monooxygenases are known to catalyse the selective hydroxylation of aromatic compounds, which is one of the most challenging chemical reactions. A set of rationally designed variants of CYP102A1 (P450 BM3) from Bacillus megaterium at the amino acid positions 47, 51, 87, 328 and 437 was screened for conversion of the substrate 3-methylanisole to vanillyl alcohol via the intermediate product 4-methylguaiacol. Furthermore, a vanillyl alcohol oxidase (VAO) variant (F454Y) was selected as an alternative enzyme for the transformation of one of the intermediate compounds via vanillyl alcohol to vanillin. As a proof of concept, the bi-enzymatic three-step cascade conversion of 3-methylanisole to vanillin was successfully evaluated both in vitro and in vivo.
Mechanism of the Ocular Hypotensive Action of Ketanserin (1985)

Ketanserin has been characterized as a relatively selective antagonist for serotonin (5-HT2) receptors. However, recent evidence suggests that ketanserin can also antagonize activity at alpha 1-adrenoceptors. Topically applied ketanserin lowered intraocular pressure (IOP) in rabbits, cats, and monkeys. Ketanserin also suppressed ocular hypertension induced by waterloading and the IOP recovery rate in response to hypertonic saline. In contrast, the ocular hypotensive activity of ketanserin was markedly attenuated in sympathectomized (SX) rabbits. In the cat nictitating membrane, ketanserin produced dose-related inhibition of contractions elicited by neuronal stimulation and by intra-arterial injection of norepinephrine. These data demonstrate that ketanserin: 1) lowers IOP more effectively in eyes with intact sympathetic innervation than in SX eyes, 2) appears to lower IOP by suppressing aqueous inflow, and 3) acts primarily by antagonizing the action of norepinephrine on alpha 1-adrenoceptors.
SMTP-4D, -5D, -6D, -7D and -8D, a New Series of the Non-lysine-analog Plasminogen Modulators with a D-Amino Acid Moiety (2003)

Staplabin and SMTPs, triprenyl phenol metabolites of the fungus Stachybotrys microspora, are a family of non-lysine-analog plasminogen modulators that enhance both activation and fibrin binding of plasminogen by modulating plasminogen conformation. These compounds, including SMTP-4, -5, -6, -7 and -8, have an amino acid or an amino alcohol moiety in their structure, and precursor amine feeding greatly increases the biosynthesis of a metabolite of interest. In the present study, we have isolated five novel SMTPs (designated SMTP-4D, -5D, -6D, -7D and -8D) from precursor D-amino acid-fed cultures. Physico-chemical properties as well as chromatographic behavior were distinct from those of the corresponding L-amino acid analogs, which are selectively accumulated in L-amino acid-fed cultures and share common properties with corresponding natural products. The D-series SMTPs enhanced urokinase-catalyzed plasminogen activation by 10-fold at 80 approximately 180 microM.
Predictably irrational: the hidden forces that shape our decisions (2008)

Why do smart people make irrational decisions every day? The answers will surprise you. Predictably Irrational is an intriguing, witty and utterly original look at why we all make illogical decisions. Why can a 50p aspirin do what a 5p aspirin can't? If an item is free it must be a bargain, right? Why is everything relative, even when it shouldn't be? How do our expectations influence our actual opinions and decisions? In this astounding book, behavioural economist Dan Ariely cuts to the heart of our strange behaviour, demonstrating how irrationality often supplants rational thought and that the reason for this is embedded in the very structure of our minds. Predicatably Irrational brilliantly blends everyday experiences with a series of illuminating and often surprising experiments, that will change your understanding of human behaviour. And, by recognising these patterns, Ariely shows that we can make better decisions in business, in matters of collective welfare, and in our everyday lives from drinking coffee to losing weight, buying a car to choosing a romantic partner.
Bayesian adaptive user profiling with explicit & implicit feedback (2006)

Research in information retrieval is now moving into a personalized scenario where a retrieval or filtering system maintains a separate user profile for each user. In this framework, information delivered to the user can be automatically personalized and catered to individual user's information needs. However, a practical concern for such a personalized system is the "cold start problem": any user new to the system must endure poor initial performance until sufficient feedback from that user is provided.To solve this problem, we use both explicit and implicit feedback to build a user's profile and use Bayesian hierarchical methods to borrow information from existing users. We analyze the usefulness of implicit feedback and the adaptive performance of the model on two data sets gathered from user studies where users' interaction with a document, or implicit feedback, were recorded along with explicit feedback. Our results are two-fold: first, we demonstrate that the Bayesian modeling approach effectively trades off between shared and user-specific information, alleviating poor initial performance for each user. Second, we find that implicit feedback has very limited unstable predictive value by itself and only marginal value when combined with explicit feedback.
test(드론 택배 도입을 위한 각국의 정책과 발전방안에 대한 연구) (2016)

드론(Drone)은 비행기나 헬리콥터와 유사한 형태로 제작된 소형 무인 비행체를 지칭한다. 최근 드론 기술이 발전을 거듭하면서 경찰의 도난 차량 추적이나 마약 수사, 재난 지역의 실종자 수색, 미디어 업계의 항공 촬영 등 활용 범위가 확산되는 추세이다. 또한 2015년 5억 달러 규모로 예상되는 민간용(civilian) 드론 시장 규모가 2023년 22억...
Bénard Cells and Taylor Vortices (1993)

Part I. Benard Convection and Rayleigh-Benard Convection: 1. Benard's experiments 2. Linear theory of Rayleigh-Benard convection 3. Theory of surface tension driven Benard convection 4. Surface tension driven Benard convection experiments 5. Linear Rayleigh-Benard convection experiments 6. Supercritical Rayleigh-Benard convection experiments 7. Nonlinear theory of Rayleigh-Benard convection 8. Miscellaneous topics Part II. Taylor Vortex Flow: 9. Circular Couette flow 10. Rayleigh's stability criterion 11. G. I. Taylor's work 12. Other early experiments 13. Supercritical Taylor vortex experiments 14. Experiments with two independently rotating cylinders 15. Nonlinear theory of Taylor vortices 16. Miscellaneous topics.
Genome properties of beet virus Q, a new furo-like virus from sugarbeet, determined from unpurified virus. (1998)

Based solely on the information that beet virus Q (BVQ) contains tubular particles, the entire nucleotide sequence of its tripartite genome was determined from unpurified virus in ca. 40 ml crude sap from locally infected Chenopodium quinoa. A starting sequence for RNA 1 was generated using primers corresponding to highly conserved helicase domains in the respective RNAs of furo-, pomo-, peclu-, hordei- and tobraviruses, and was extended by a walking random-primed cDNA approach. The similarity of the 3' ends of furoviral RNAs allowed starting sequences for BVQ RNAs 2 and 3 to be obtained once the 3' end of RNA 1 was known. BVQ RNA 1 encodes a protein with a methyltransferase-like, a variable and a helicase-like region, and for a readthrough protein which, in addition, contains an RNA-dependent RNA polymerase region. RNA 2 carries the coat protein gene, a coat protein read-through protein gene and two additional ORFs which may have arisen by deletions from an originally larger readthrough domain. RNA 3 carries a triple gene block resembling that of several other rod-shaped viruses. The 5' UTRs of the three RNAs have the potential to form a series of hairpins with C-A and C-C mismatches resembling those found in tymoviral RNAs. The 3' ends can be folded into tRNA-like structures which are preceded by a long hairpin-like structure and an upstream pseudoknot domain. BVQ belongs to the recently proposed genus Pomovirus; it shows evolutionary relationships to furoviruses in sensu stricto, peclu-, hordei-, tobra-, tymo-, tobamo-, carla- and potexviruses.
Reaction mechanism from structure-energy relations. 1. Base-catalyzed addition of alcohols to formaldehyde (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction mechanism from structure-energy relations. 1. Base-catalyzed addition of alcohols to formaldehydeErnest GrunwaldCite this: J. Am. Chem. Soc. 1985, 107, 16, 4710–4715Publication Date (Print):August 1, 1985Publication History Published online1 May 2002Published inissue 1 August 1985https://pubs.acs.org/doi/10.1021/ja00302a018https://doi.org/10.1021/ja00302a018research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Design notes for Electric's network consistency checker (2006)

This technical report is a collection of the memos written by members of the VLSI Research Group in 2004 and 2005 about Electric's Network Consistency Checker, NCC. Be warned that these memos are unrefined design notes, not polished papers. For the most part, these memos were written to help us think through problems; as such, they may contain errors and conjectures that have not been fully proven. Despite that, we've created this report so that we can share our ideas and collaborate with people outside of Sun.
Darstellung und stereoselektive Reaktionen von (<i>R</i>)‐α‐Sulfonyloxynitrilen (1991)

Die Sulfonylierung von ( R )‐Cyanhydrinen ( R )‐ 1 zu ( R )‐ 2 verläuft racemisierungsfrei. Die Umsetzung von ( R )‐ 2 mit Nucleophilen liefert ‐ ebenfalls racemisierungsfrei ‐ unter Konfigurationsumkehr Cyanhydrine ( S )‐ 3 (Nu = OAc, N 3 , N ‐Phthaloyl), die als Synthesezwischenstufen interessant sind. magnified image