gebhart/patrepeval huggingface dataset:
Insulin and insulin-like growth factor II permit nerve growth factor binding and the neurite formation response in cultured human neuroblastoma cells. (1984)

In serum-free medium, SH-SY5Y human neuroblastoma cells specifically and reversibly lost the capacity to bind 125I-labeled nerve growth factor (NGF) to the high-affinity sites (slow sites) and to respond by neurite outgrowth, unless physiological concentrations of insulin or insulin-like growth factor II were present. In serum-containing medium, anti-insulin antiserum decreased the neurite formation response to NGF, and insulin supplementation increased the number of available NGF slow sites. The low-affinity NGF fast sites are absent from SH-SY5Y cells and did not emerge on treatment with insulin. Insulin potentiated the induction of neurites by NGF in rat pheochromocytoma PC12 cells also. These results implicate a wider role for insulin and its homologs in the nervous system.
Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate (2009)

Oct4 exerts a dose-dependent dual action, as both a gatekeeper for stem cell pluripotency and in driving cells toward specific lineages. Here, we identify the molecular mechanism underlying this dual function. BMP2- or transgene-induced Oct4 up-regulation drives human embryonic and induced pluripotent stem cells to become cardiac progenitors. When embryonic stem cell pluripotency is achieved, Oct4 switches from the Sox2 to the Sox17 promoter. This switch allows the cells to turn off the pluripotency Oct4-Sox2 loop and to turn on the Sox17 promoter. This powerful process generates a subset of endoderm-expressing Sox17 and Hex, both regulators of paracrine signals for cardiogenesis (i.e., Wnt, BMP2) released into the medium surrounding colonies of embryonic stem cells. Our data thus reveal a novel molecular Oct4- and Sox17-mediated mechanism that disrupts the stem cell microenvironment favoring pluripotency to provide a novel paracrine endodermal environment in which cell lineage is determined and commits the cells to a cardiogenic fate.
The First Draft of the Endostatin Interaction Network (2009)

Endostatin is a C-terminal proteolytic fragment of collagen XVIII that is localized in vascular basement membrane zones in various organs. It binds to heparin/heparan sulfate and to a number of proteins, but its molecular mechanisms of action are not fully elucidated. We have used surface plasmon resonance (SPR) arrays to identify new partners of endostatin, and to give further insights on its molecular mechanism of action. New partners of endostatin include glycosaminoglycans (chondroitin and dermatan sulfate), matricellular proteins (thrombospondin-1 and SPARC), collagens (I, IV, and VI), the amyloid peptide Abeta-(1-42), and transglutaminase-2. The biological functions of the endostatin network involve a number of extracellular proteins containing epidermal growth factor and epidermal growth factor-like domains, and able to bind calcium. Depending on the trigger event, and on the availability of its members in a given tissue at a given time, the endostatin network might be involved either in the control of angiogenesis, and tumor growth, or in neurogenesis and neurodegenerative diseases.
Scalable NIDS via Negative Pattern Matching and Exclusive Pattern Matching (2010)

In this paper, we identify the unique challenges in deploying parallelism on TCAM-based pattern matching for Network Intrusion Detection Systems (NIDSes). We resolve two critical issues when designing scalable parallelism specifically for pattern matching modules: 1) how to enable fine-grained parallelism in pursuit of effective load balancing and desirable speedup simultaneously; and 2) how to reconcile the tension between parallel processing speedup and prohibitive TCAM power consumption. To this end, we first propose the novel concept of Negative Pattern Matching to partition flows, by which the number of TCAM lookups can be significantly reduced, and the resulting (fine-grained) flow segments can be inspected in parallel without incurring false negatives. Then we propose the notion of Exclusive Pattern Matching to divide the entire pattern set into multiple subsets which can later be matched against selectively and independently without affecting the correctness. We show that Exclusive Pattern Matching enables the adoption of smaller and faster TCAM blocks and improves both the pattern matching speed and scalability. Finally, our theoretical and experimental results validate that the above two concepts are inherently complementary, enabling our integrated scheme to provide performance gain in any scenario (with either clean or dirty traffic).
Modeling and design of a normal stress electromagnetic actuator with linear characteristics for fast steering mirror (2014)

A new rotary normal stress electromagnetic actuator for fast steering mirror (FSM) is presented. The study includes concept design, actuating torque modeling, actuator design, and validation with numerical simulation. To achieve an FSM with compact structure and high bandwidth, the actuator is designed with a cross armature magnetic topology. By introducing bias flux generated by four permanent magnets (PMs), the actuator has high-force density similar to a solenoid but also has essentially linear characteristics similar to a voice coil actuator, leading to a simply control algorithm. The actuating torque output is a linear function of both driving current and rotation angle and is formulated with equivalent magnetic circuit method. To improve modeling accuracy, both the PM flux and coil flux leakages are taken into consideration through finite element simulation. Based on the established actuator model, optimal design of the actuator is presented to meet the requirement of our FSM. Numerical simulation is then presented to validate the concept design, established actuator model, and designed actuator. It is shown that the calculated results are in a good agreement with the simulation results.
Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channels (1996)

The alpha-subunit encoding for voltage-gated sodium channels rSkM1 (rat skeletal muscle subtype 1) and hH1 (human heart subtype 1) has been cloned and expressed by various groups under various conditions in Xenopus oocytes and the tsA201 (HEK 293) mammalian cell line derived from human embryonic kidney cells. In this study, we have expressed hH1 and rSkM1 in tsA201 cells for comparison under the same conditions using patch-clamp methods. Our results show significant differences in the current-voltage (I-V) relationship, kinetics of current decay, voltage dependence of steady-state inactivation, and the time constant for recovery from inactivation. We studied several rSkM1/hH1 chimeric sodium channels to identify the structural regions responsible for the different biophysical behavior of the two channel subtypes. Exchanging the interdomain (ID3-4) loops, thought to contain the inactivation particle, between rSkM1 and hH1 had no effect on the electrophysiological behaviors, including inactivation, indicating that the differences in channel subtype characteristics are determined by parts of the channel other than the ID3-4 segment. The data on a chimeric channel in which D1 and D4 are derived from hH1 while D2 and D3 and the ID1-2, ID2-3, and ID3-4 loops are from rSkM1 show that D1 and/or D4 seem to be responsible for the slower kinetics of inactivation of hH1 while D2 and/or D3 appear to contain the determinants for the differences in the I-V relationship, steady-state inactivation (h infinity) curve, and the kinetics of the recovery from inactivation.
Real time full-duplex H.263 video codec system (2002)

A real-time H.263 video codec system is presented is this paper. The TMS320C80 which consists of four parallel DSPs is used in the system. A few strategies are used to reduce the computation complexity and hence increase the frame rate. The parallel implementation of the H.263 algorithm on the parallel DSPs is described and the performance of the real-time codec is discussed.
Characterisation of cure distribution in surface initiated redox polymerisations by dynamic mechanical and dielectric thermal analyses (1991)

Dymanic mechanical and dielectric thermal analyses (DMTA and DETA) have been used to study heterogeneous cure in surface initiated bulk polymerisations at room temperature. Surfaces have been modified by copper salt based or purely organic activators and the effects of the thus modified substrates have been compared with the behaviour on untrearted surfaces
蒂莫西·斯波 长风破浪会有时 (2014)

他身形硕大,并非英俊。如果在人群中看到他一定不会觉得有多与众不同,但就是这样,蒂莫西·斯波凭借几近无声的付出最终擒获戛纳影帝头衔。他代表着好莱坞的一大批老戏骨,他们演技精湛、锦上添花。
Simple water flow control for the Coulson electrolytic conductivity detector (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple water flow control for the Coulson electrolytic conductivity detectorJ. F. Lawrence and N. P. SenCite this: Anal. Chem. 1975, 47, 2, 367–368Publication Date (Print):February 1, 1975Publication History Published online1 May 2002Published inissue 1 February 1975https://pubs.acs.org/doi/10.1021/ac60352a035https://doi.org/10.1021/ac60352a035research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiwavelength erbium-doped fiber lasers with active overlapping linear cavities (2003)

Multiwavelength oscillations in erbium-doped fiber (EDF) lasers with active overlapping linear cavities are investigated in detail. The laser can be designed to produce multiwavelength oscillations in the C-band and in the L-band. With a C-band three-wavelength laser, experiments show that the output powers of the lasing lines increase linearly or piecewise linearly with pump input. Any one lasing wavelength can be tuned over several nanometers depending on the gain tilt in the vicinity of the lasing wavelength while multiwavelength oscillation is still being maintained. The output power of any specific lasing line can be adjusted by suitably designing the EDF sections. This property also allows the laser to operate in multiwavelength switching mode. The laser exhibits a novel multiwavelength optical bistable behavior in the L-band. With an L-band dual-wavelength laser, the bistable input-output hysteresis behaviors of the two L-band wavelengths evolve in antiphase with respect to each other. The width of the bistable region has been increased to several tens of mW. It can be controlled and adjusted by the cavity loss and the EDF length. It is found that simultaneous L-band dual-wavelength oscillations can be obtained when part of the EDF, which functions as a saturable absorber, has been bleached. Moreover, simultaneous multiwavelength oscillations in both C-band and L-band have also been successfully demonstrated with the laser.
<b>Insulin Peptides. IX. The Synthesis of the A-Chain of Insulin and its Combination with Natural B-Chain to Generate Insulin Activity</b> (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInsulin Peptides. IX. The Synthesis of the A-Chain of Insulin and its Combination with Natural B-Chain to Generate Insulin ActivityPanayotis G. Katsoyannis, Andrew. Tometsko, and Kouhei. FukudaCite this: J. Am. Chem. Soc. 1963, 85, 18, 2863–2865Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://pubs.acs.org/doi/10.1021/ja00901a052https://doi.org/10.1021/ja00901a052research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Characterization of Monodisperse Hollow Fe<sub>3</sub>O<sub>4</sub> Nanoparticles (2007)

Controlled oxidation of amorphous core–shell Fe–Fe3O4 nanoparticles in a simple solution-phase process affords monodisperse hollow Fe3O4 nanoparticles. Self-assembly of the monodisperse hollow Fe3O4 nanoparticles leads to superlattice arrays (see TEM image). The synthesis offers a general approach to hollow iron oxide and core–shell–void Fe–Fe3O4 nanoparticles that may have potential applications in catalysis and high-frequency electromagnetic devices. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700677_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Mifepristone Induces Growth Arrest, Caspase Activation, and Apoptosis of Estrogen Receptor-Expressing, Antiestrogen-Resistant Breast Cancer Cells (2004)

We demonstrate that: (a) estrogen receptor(+)progesterone receptor(+), 4-OHT-resistant clonal variants can be isolated from an MCF-7 cell line in the absence of antiestrogen selection; and (b) MIF and MIF plus 4-OHT combination therapy induces growth arrest and active cell death of the antiestrogen-resistant breast cancer cells. These preclinical findings show potential for a combined hormonal regimen of an antiestrogen and an antiprogestin to combat the emergence of antiestrogen-resistant breast cancer cells and, ultimately, improve the therapeutic index of antiestrogen therapy.
Dielectrically Isolated High Voltage IC Using Complementary Gated MOS Thyristors (1989)

A novel monolithic semiconductor switch, which is electrically isolated between input and output and can be turned on and turned off under a floating bias condition, has been developed. This high voltage switch is achieved by using antiparallel COGMOS (Complementary Gated MOS) thyristors whose structure incorporates two MOS gate electrodes formed over the p base and n base of a pnpn thyristor, and several driver circuits fabricated by a dielectric isolation process.
Pressure Sore and Skin Tear Prevention and Treatment During a 10-Month Program (2005)

This article reports the results of a 10-month skin care program for 30 clients on a residential Alzheimer's disease unit. The majority (n = 26) of the clients were free of pressure sores and skin tears through preventive care during this study. Four clients with Stage I pressure sores and/or skin tears were successfully identified by consistent assessment and healed quickly due to rapidly initiated treatments. This skin care program's success was attributed to consistent education, preventive care, assessment, documentation, and treatment executed by the entire care team under the leadership of nurse practitioners, one of whom was certified as a rehabilitation nurse.
Automatic summarization for text simplification (2008)

In this paper we present experiments on summarization and text simplification for poor readers, more specifically, functional illiteracy readers. We test several summarizers and use summaries as the basis of simplification strategies. We show that each simplification approach has different effects on readers of varied levels of literacy, but that all of them do improve text understanding at some level.
황련해독탕(黃連解毒湯)이 외열 스트레스(火邪)에 의한 동물모델에서 c-fos 발현에 미치는 영향 연구 (2014)

Objectives: Hwangryunhaedok-tang (HH) is a representative heat clearing multiherb prescription. We evaluated the protective effect of HH against heat stress exposure in mice. Methods: Six weeks old ICR mice were used for this study. After 43℃ heat stressfor 15 minutes, we evaluated the changes of motor activity and c-fos expression level to determine the proper heat stress and evaluation time. The subjects were divided into 4 groups (1. control group, 2. heat stress group with normal saline, 3. heat stress group with administration of 100 mg/kg, and 4. heat stress group with administration of 1000 mg/kg). After oral administration of HH once a day for 3 days,2, 3, 4 groups were exposed to 43℃ heat stress for 15 minutes. Then, we evaluated the motor activity for 120 minutes and analyzed the c-fos expression using western blot. We investigated the effect of HH and its ingredients on c-fos expressions afterheat stress. The mice were administrated HH, Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, and Gardeniae Fructus for 3 days. After one hour of last treatment, the mice were exposed to heat stress at 43℃ for 15 min. After two hours, the hypothalamus was dissociated and lysed to measure c-fos expression. Results: After oral administration of HH for 3 days, motor activity was recovered insignificantly. 100 mg/kg HH treatment reduced the c-fos expression after heat stress but insignificantly. Among the ingredients of HH, Coptidis Rhizoma and Scutellariae Radix treatment groups significantly reduced the c-fos after stress. Conclusions: These results show that Hwangryunhaedok-tang may be effective to reduce the heat stress response.
A programmable instrumentation amplifier for 12-bit resolution systems (1982)

Describes the design of and experimental results obtained from a monolithic gain-programmable instrumentation amplifier that attains performance compatible with 12-bit or higher resolution data acquisition systems. Nonlinearity is held to a 0.01 percent worst-case level over the -25 to 85/spl deg/C temperature range for gains of 1-1000, independent of process variations. Input and output voltage noise and offset drift are also reduced to low levels. A novel input overvoltage protection scheme is also described. The amplifier is fabricated on a standard-beta junction isolated bipolar process that has in addition process-compatible ion implanted JFETs and silicon-chromium thin-film resistors.
Facile and Sustainable Synthesis of Shaped Iron Oxide Nanoparticles: Effect of Iron Precursor Salts on the Shapes of Iron Oxides (2015)

A facile and sustainable protocol for synthesis of six different shaped iron oxides is developed. Notably, all the six shapes of iron oxides can be synthesised using exactly same synthetic protocol, by simply changing the precursor iron salts. Several of the synthesised shapes are not reported before. This novel protocol is relatively easy to implement and could contribute to overcome the challenge of obtaining various shaped iron oxides in economical and sustainable manner.
Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis (2013)

We suggest that reduction of oxidative stress may play a role in this anti-inflammatory effect.
Novel effect of carbon dioxide on catalyst properties. Dimerization of butadiene (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel effect of carbon dioxide on catalyst properties. Dimerization of butadieneJosef F. Kohnle, Lynn H. Slaugh, and K. L. NakamayeCite this: J. Am. Chem. Soc. 1969, 91, 21, 5904–5905Publication Date (Print):October 1, 1969Publication History Published online1 May 2002Published inissue 1 October 1969https://pubs.acs.org/doi/10.1021/ja01049a052https://doi.org/10.1021/ja01049a052research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The <i>ripX</i> Locus of <i>Bacillus subtilis</i> Encodes a Site-Specific Recombinase Involved in Proper Chromosome Partitioning (1999)

The Bacillus subtilis ripX gene encodes a protein that has 37 and 44% identity with the XerC and XerD site-specific recombinases of Escherichia coli. XerC and XerD are hypothesized to act in concert at the dif site to resolve dimeric chromosomes formed by recombination during replication. Cultures of ripX mutants contained a subpopulation of unequal-size cells held together in long chains. The chains included anucleate cells and cells with aberrantly dense or diffuse nucleoids, indicating a chromosome partitioning failure. This result is consistent with RipX having a role in the resolution of chromosome dimers in B. subtilis. Spores contain a single uninitiated chromosome, and analysis of germinated, outgrowing spores showed that the placement of FtsZ rings and septa is affected in ripX strains by the first division after the initiation of germination. The introduction of a recA mutation into ripX strains resulted in only slight modifications of the ripX phenotype, suggesting that chromosome dimers can form in a RecA-independent manner in B. subtilis. In addition to RipX, the CodV protein of B. subtilis shows extensive similarity to XerC and XerD. The RipX and CodV proteins were shown to bind in vitro to DNA containing the E. coli dif site. Together they functioned efficiently in vitro to catalyze site-specific cleavage of an artificial Holliday junction containing a dif site. Inactivation of codV alone did not cause a discernible change in phenotype, and it is speculated that RipX can substitute for CodV in vivo.