gebhart/patrepeval huggingface dataset:
안면신경 마비 환자에 있어서의 측두근 및 근막 피판을 이용한 안면근 기능 회복 증례보고 (1994)

Generally, the totally paralyzed face can never be made normal by any of the current methods of reconstruction. Careful selection of patients based on sound judgment of what can and cannot be achieved by the proposed surgical technique is paramount to a successful operation and a satisfied patient. The results are related to time of delayed between injury and repair ; the shorter the delay the better are the results. The objectives in correcting facial paralysis are to achieve normal appearance at rest : symmetry with voluntary motion : control of the ocular, oral, and nasal sphincter: symmetry with involuntary emotion and controlled balance when expressing emotion ; and no significant functional deficit secondary to the reconstructive surgery. It must be employed a number of concepts, for treatment of the paralyzed face by surgeon, depending on the cause, time interval, and wound characteristics, as well as the availability of and necessity for neuromuscular substitution. Nerve grafts, crossovers, muscle transfers, free muscle and nerve-muscle grafts, micronuerovascular muscle transfers, and regional muscle transposition are the principal methods being developed. We applied the temporal muscle transposition for reanimation of unilatrally paralyzed faces for long times on two patients. The results of muscle transposition can be enhanced by the patients learning to activate the transposed muscle by voluntary effort, and are best in patients who are motivated to learn the necessary motor-sensory coordination techniques.
Effect of nominal composition on the superconductivity in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">La</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mi mathvariant="normal">Cu</mml:mi><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>4</mml:mn><mml:mo>−</mml:mo><mml:mi>y</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> (1987)

Samples of ${\mathrm{La}}_{2}$Cu${\mathrm{O}}_{4}$ prepared with a nominal stoichiometry slightly deficient in lanthanum (i.e., ${\mathrm{La}}_{1.9}$Cu${\mathrm{O}}_{4}$) show a greater diamagnetic susceptibility and a sharper resistive transition than samples prepared from stoichiometric amounts of starting materials. The effect of adding ${\mathrm{K}}_{2}$C${\mathrm{O}}_{3}$ to the reaction mixture is also discussed.
The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition (2016)

Multiple glycosyltransferases are essential for the proper modification of alpha-dystroglycan, as mutations in the encoding genes cause congenital/limb-girdle muscular dystrophies. Here we elucidate further the structure of an O-mannose-initiated glycan on alpha-dystroglycan that is required to generate its extracellular matrix-binding polysaccharide. This functional glycan contains a novel ribitol structure that links a phosphotrisaccharide to xylose. ISPD is a CDP-ribitol (ribose) pyrophosphorylase that generates the reduced sugar nucleotide for the insertion of ribitol in a phosphodiester linkage to the glycoprotein. TMEM5 is a UDP-xylosyl transferase that elaborates the structure. We demonstrate in a zebrafish model as well as in a human patient that defects in TMEM5 result in muscular dystrophy in combination with abnormal brain development. Thus, we propose a novel structure-a ribitol in a phosphodiester linkage-for the moiety on which TMEM5, B4GAT1, and LARGE act to generate the functional receptor for ECM proteins having LG domains.
Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons (1997)

Protons have long been recognized as low LET radiation in radiotherapy. However, a detailed account of LET (linear energy transfer) and RBE (relative biological effectiveness) changes with incident beam energy and depth in tissue is still unresolved. This issue is particularly important for treatment planning, where the physical dose prescription is calculated from a RBE using cobalt as the reference radiation. Any significant RBE changes with energy or depth will be important to incorporate in treatment planning. In this paper we present microdosimetry spectra for the proton beam at various energies and depths and compare the results to cell survival studies performed at Loma Linda. An empirically determined biological weighting function that depends on lineal energy is used to correlate the microdosimetry spectra with cell survival data. We conclude that the variations in measured RBE with beam energy and depth are small until the distal edge of the beam is reached. On the distal edge, protons achieve stopping powers as high as 100 keV/micron, which is reflected in the lineal energy spectra taken there. Lineal energy spectra 5 cm beyond the distal edge of the Bragg peak also show a high LET component but at a dose rate 600 times smaller than observed inside the proton field.
A virtual coaching environment for improving golf swing technique (2010)

As a proficient golf swing is a key element of success in golf, many golfers make significant effort improving their stroke mechanics. In order to help enhance golfing performance, it is important to identify the performance determining factors within the full golf swing. In addition, explicit instructions on specific features in stroke technique requiring alterations must be imparted to the player in an unambiguous and intuitive manner. However, these two objectives are difficult to achieve due to the subjective nature of traditional coaching techniques and the predominantly implicit knowledge players have of their movements. In this work, we have developed a set of visualisation and analysis tools for use in a virtual golf coaching environment. In this virtual coaching studio, the analysis tools allow for specific areas require improvement in a player's 3D stroke dynamics to be isolated. An interactive 3D virtual coaching environment then allows detailed and unambiguous coaching information to be visually imparted back to the player via the use of two virtual human avatars; the first mimics the movements performed by the player; the second takes the role of a virtual coach, performing ideal stroke movement dynamics. The potential of the coaching tool is highlighted in its use by sports science researchers in the evaluation of competing approaches for calculating the X-Factor, a significant performance determining factor for hitting distance in a golf swing.
Application of Lectin Array Technology for Biobetter Characterization: Its Correlation with FcγRIII Binding and ADCC (2016)

Lectin microarray technology was applied to compare the glycosylation pattern of the monoclonal antibody MB311 expressed in SP2.0 cells to an antibody-dependent cellular cytotoxic effector function (ADCC)-optimized variant (MB314). MB314 was generated by a plant expression system that uses genetically modified moss protoplasts (<i>Physcomitrella patens</i>) to generate a de-fucosylated version of MB311. In contrast to MB311, no or very low interactions of MB314 with lectins <i>Aspergillus oryzae</i> l-fucose (AOL), <i>Pisum sativum</i> agglutinin (PSA), <i>Lens culinaris</i> agglutinin (LCA), and <i>Aleuria aurantia</i> lectin (AAL) were observed. These lectins are specific for mono-/biantennary N-glycans containing a core fucose residue. Importantly, this fucose indicative lectin-binding pattern correlated with increased MB314 binding to CD16 (FcγRIII; receptor for the constant region of an antibody)-whose affinity is mediated through core fucosylation-and stronger ADCC. In summary, these results demonstrate that lectin microarrays are useful orthogonal methods during antibody development and for characterization.
Book announcement: Introduction to Multi-Armed Bandits (2020)

"Introduction to multi-armed bandits" is a broad and accessible textbook which emphasizes connections to economics and operations research.
Edge effects in pixelated CdZnTe gamma detectors (2004)

Edge effects in pixelated CdZnTe detectors occur due to the high dielectric constant of the CdZnTe detector material, and the tendency of the field lines emanating from the "hole" charge carriers to remain within the detector volume. As a result, spectra for edge and corner pixels tend to exhibit a longer low energy tail at the expense of the number of events in the photo-peak. We focus on a thick pixelated CdZnTe detector, where, the detector thickness is comparable to the lateral size. We develop a theoretical Monte-Carlo simulation that well describes the experimentally observed edge effects. We show that when the same detector is embedded in an array of similar detector at the same HV, the edge effects disappear, and the spectral properties the edge and corner pixels improve markedly.
Hyaluronan forms specific stable tertiary structures in aqueous solution: A <sup>13</sup> C NMR study (1999)

13C NMR spectra of aqueous solutions of hyaluronan (HA) of high molecular mass, before and after digestion with testicular hyaluronidase, and of hyaluronan methyl ester were obtained at 125.8 MHz. Carbonyl peaks were assigned by using selective decoupling techniques. Spectra of digested and undigested HA showed sharp signals, except for that assigned to the acetamido carbonyl carbon in the high polymer, which was much broadened. The decreased mobility of this C==O, thus demonstrated, was caused by restricted rotation. As part of the rigid CO---NH unit, rotation of NH was therefore similarly restricted, probably because of an intermolecular H bond from NH to carboxylate groups on neighbouring HA molecules. This bond was confirmed by comparing esterified HA with unmodified HA. Methyl esterification of carboxylates was accompanied by changes in acetamido C==O resonances consistent with increased mobility of CO---NH groups. Ester C==O resonances were sharp, proving that they did not participate in sterically restricted structures such as the proposed H bonds involving unesterified carboxylate groups. C==O resonances report on the environments and on the interrelationships of amide and carboxylate groups. A detailed structure suggested for high-molecular-mass HA in aqueous solution takes account of NMR and x-ray fiber diffraction data. Antiparallel HA chains overlap in meshworks stabilized by specific H bonds and hydrophobic bonds. This highly cooperative structure, formally equivalent to beta-sheets seen in proteins, is not stable in low-molecular-mass HA solution. The results relate to structures proposed for shape modules in extracellular matrix involving chondroitin and keratan sulfates, which resemble HA in their stereochemistry.
Analysis of the Dihydropyridine Receptor Site ofl-type Calcium Channels by Alanine-scanning Mutagenesis (1997)

The dihydropyridine Ca2+ antagonist drugs used in the therapy of cardiovacular disorders inhibit L-type Ca2+ channels by binding to a single high affinity site. Photoaffinity labeling and analysis of mutant Ca2+ channels implicate the IIIS6 and IVS6 segments in high affinity binding. The amino acid residues that are required for high affinity binding of dihydropyridine Ca2+ channel antagonists were probed by alanine-scanning mutagenesis of the alpha1C subunit, transient expression in mammalian cells, and analysis by measurements of ligand binding and block of Ba2+ currents through expressed Ca2+ channels. Eleven amino acid residues in transmembrane segments IIIS6 and IVS6 were identified whose mutation reduced the affinity for the Ca2+ antagonist PN200-110 by 2-25-fold. Both amino acid residues conserved among Ca2+ channels and those specific to L-type Ca2+ channels were found to be required for high affinity dihydropyridine binding. In addition, mutation F1462A increased the affinity for the dihydropyridine Ca2+ antagonist PN200-110 by 416-fold with no effect on the affinity for the Ca2+ agonist Bay K8644. The residues in transmembrane segments IIIS6 and IVS6 that are required for high affinity binding are primarily aligned on single faces of these two alpha helices, supporting a "domain interface model" of dihydropyridine binding and action in which the IIIS6 and IVS6 interact to form a high affinity dihydropyridine receptor site on L-type Ca2+ channels.
Monoclonal antibody-based therapy of a human tumor xenograft with a 177lutetium-labeled immunoconjugate. (1991)

177Lutetium (177Lu) is a member of the family of elements known as lanthanides or rare earths. Monoclonal antibody (MAb) CC49, a murine IgG1, which is reactive with the tumor-associated antigen, TAG-72, has been shown previously to react with a wide range of human carcinomas; CC49 reacts to a different epitope on the TAG-72 molecule than MAb B72.3 and has a higher binding affinity. We report here the first use of a 177Lu-labeled immunoconjugate, 177Lu-CC49, in an experimental therapy model for human carcinoma. 177Lu-CC49 was shown to delay the growth of established LS-174T human colon carcinomas in athymic mice at a single dose of 50 microCi. Overt toxicity was observed with the administration of approximately 500 microCi of 177Lu-CC49 in which 5 of 9 mice died of apparent marrow toxicity. A single administration of 200 or 350 microCi of 177Lu-CC49, however, was shown to eliminate established tumors through the 77-day observation period after MAb administration. Dose fractionation experiments revealed that at least 750 microCi of 177Lu-CC49 (250 microCi/week for 3 consecutive weeks) was well tolerated in that 9 of 10 mice survived. Moreover, this dose schedule was able to eliminate the growth of relatively large (300 mm3) human colon tumor xenografts in 90% of the animals treated. Single-dose and dose fractionation studies were also carried out with an isotype-matched control MAb, 177Lu-MOPC-21. In all dose schedules, a large differential was seen between the therapeutic effects of the 177Lu-CC49 versus that of the 177Lu-control MAb. The merits and limitations of the use of 177Lu-labeled immunoconjugates (in particular, 177Lu-CC49) are discussed in terms of potential novel therapeutics for human carcinoma.
Physical Properties of High Molecular Weight Alkylbenzenes and Alkylcyclohexanes. (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticlePhysical Properties of High Molecular Weight Alkylbenzenes and Alkylcyclohexanes.J. A. Dixon and S. G. Clark IICite this: J. Chem. Eng. Data 1959, 4, 1, 94–96Publication Date (Print):January 1, 1959Publication History Published online1 May 2002Published inissue 1 January 1959https://pubs.acs.org/doi/10.1021/je60001a014https://doi.org/10.1021/je60001a014research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Skid prevention for EVs based on the emulation of torque characteristics of separately-wound DC motor (2004)

It is well-known that the separately-wound DC motor has effective torque (current) reduction characteristics in response to rapid increase of the rotational speed of the motor. This characteristics has been utilized in adhesion control of electric locomotives with DC motor. In this paper, how to realize a new skid prevention method for EVs utilizing this characteristics is mentioned. In order to compensate for Back-EMF, disturbance observer is introduced. By selecting the time constant or observer gain properly, the torque (current) reduction characteristics can be adjusted freely in some range. The experimental results of the hardware skid simulator utilizing Motor-Generator setup verified the effectiveness of our proposed method.
Structure and dynamics of a constitutively active neurotensin receptor (2016)

Many G protein-coupled receptors show constitutive activity, resulting in the production of a second messenger in the absence of an agonist; and naturally occurring constitutively active mutations in receptors have been implicated in diseases. To gain insight into mechanistic aspects of constitutive activity, we report here the 3.3 Å crystal structure of a constitutively active, agonist-bound neurotensin receptor (NTSR1) and molecular dynamics simulations of agonist-occupied and ligand-free receptor. Comparison with the structure of a NTSR1 variant that has little constitutive activity reveals uncoupling of the ligand-binding domain from conserved connector residues, that effect conformational changes during GPCR activation. Furthermore, molecular dynamics simulations show strong contacts between connector residue side chains and increased flexibility at the intracellular receptor face as features that coincide with robust signalling in cells. The loss of correlation between the binding pocket and conserved connector residues, combined with altered receptor dynamics, possibly explains the reduced neurotensin efficacy in the constitutively active NTSR1 and a facilitated initial engagement with G protein in the absence of agonist.
Preparation and properties of thin amorphous tantalum films formed by small e-beam evaporators (2009)

Large area (A = 6 cm2), thin tantalum films (5 nm < d < 100 nm) are accomplished by evaporation from tantalum rods using small pocket e-beam evaporators. Using a sample to source distance of ≈20 cm, homogeneous amorphous films with a small surface roughness (<1 nm) can be prepared on glass. Films are characterized by scanning electron microscope images, atomic force microscopy, electrochemical oxidation and resistivity measurements as a function of film thickness. The samples show high resistivities of 200–2000 µΩ cm. The temperature coefficient of the resistivity (TCR) is negative, as characteristic for highly disordered metals. A theoretical description of the thickness distribution (evaporation from plane and hemispherical sources on plane targets) is given in the appendix.
Deep Space 2: The Mars Microprobe Mission (1999)

The Mars Microprobe Mission will be the second of the New Millennium Program's technology development missions to planetary bodies. The mission consists of two penetrators that weigh 2.4 kg each and are being carried as a piggyback payload on the Mars Polar Lander cruise ring. The spacecraft arrive at Mars on December 3, 1999. The two identical penetrators will impact the surface at ∼190 m/s and penetrate up to 0.6 m. They will land within 1 to 10 km of each other and ∼50 km from the Polar Lander on the south polar layered terrain. The primary objective of the mission is to demonstrate technologies that will enable future science missions and, in particular, network science missions. A secondary goal is to acquire science data. A subsurface evolved water experiment and a thermal conductivity experiment will estimate the water content and thermal properties of the regolith. The atmospheric density, pressure, and temperature will be derived using descent deceleration data. Impact accelerometer data will be used to determine the depth of penetration, the hardness of the regolith, and the presence or absence of 10 cm scale layers.
Sustained delivery of doxorubicin using biodegradable pH/temperature-sensitive poly(ethylene glycol)-poly(β-amino ester urethane) multiblock copolymer hydrogels (2011)

Polymers containing amino urethane groups have great potential as polymeric hydrogel carriers for the delivery of drugs/proteins because of their non-toxicity and ability to form hydrogen bonds and ionic interactions with biomolecules. However, the reported gels have high molecular weights and/or are non-biodegradable or showed fast degradation. This study examined a series of low molecular weight, biodegradable pH/temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) (PEG) and poly(β-amino ester urethane) (PAEU) and their potential appication for drug sustained release. The copolymers were synthesized and characterized by 1H and 13C NMR, Fourier transform infrared spectroscopy and gel permeation chromatography. Aqueous solutions of the copolymer showed a gel-to-sol phase transition as a function of temperature in the pH range of 6.8–7.6. The gel window covered the physiological conditions (37 °C, pH 7.4). The gel region could be controlled by changing PEG/PAEU ratio, copolymer solution concentration and PEG molecular weight. A gel formed rapidly in situ after injecting the copolymer solution subcutaneously into SD rats. The non-cytotoxicity of this hydrogel was confirmed by in vitro cytotoxicity test and the in vitro release of doxorubicin from this hydrogel was sustained for more than 5 weeks. This novel injectable biodegradable pH/temperature-sensitive hydrogels can be a potential candidate for drugs carrier.
A web-based ETL tool for data integration process (2013)

Extract, Transform and Load (ETL) is a fundamental process used to populate a data warehouse and an important step towards data integration which is a key step for data preprocessing for many data mining projects. The objective of this project is to create a simple web based ETL tool which can be accessed by anyone with internet access. This ETL tool is also supported by a brief on-line tutorial on ETL process. The combination of tool and tutorial makes an ideal self-paced interactive learning tool for a beginning ETL learner. Guests will have limited access to this tool and registered users can have complete access. Using this tool, data can be extracted from text files or MySQL tables, integrated and loaded into target MySQL tables. Before loading the data into target MySQL tables, various transformations can also be applied to them.
Intranasal vaccination with poly(lactide‐<i>co</i>‐glycolide) microparticles containing a peptide T of Ole e 1 prevents mice against sensitization (2008)

These results demonstrate that i.n. immunization with peptide T-PLGA microparticles is effective in preventing subsequent allergic sensitization to Ole e 1. Our data indicate that peptide-PLGA microparticles may be promising candidates for the design of nasal vaccines against allergic diseases in humans.