gebhart/patrepeval huggingface dataset:
A COMPARISON OF THE USE OF TWO IMMUNOMAGNETIC MICROSPHERES FOR SECONDARY PURIFICATION OF PANCREATIC ISLETS1 (1996)

Immunomagnetic cell separation has been shown to be a highly attractive alternative to density-dependent methods for islet purification. There are two types of beads, magnetic inducible microspheres (MIMS) and Dynabeads, in this context. The aim of this study was to compare the two beads and ligands using the same method of purification. Two batches of collagenase were used. Using either monoclonal antibodies or lectins with a specificity for rat acinar tissue, the beads were used to immunomagnetically label pancreatic digest before magnetic separation. The results showed that both MIMS coated with a lectin and Dynabeads coated with an antibody removed 80% of the acinar contamination with a 70% islet yield. However, the MIMS were significantly less effective with the second enzyme, which produced larger acinar particles. In this study, although the MIMS produced the least nonspecific islet trapping, the Dynabeads coated with Leicester Department of Surgery no. 10 antibody were found to be the most efficient particle for immunomagnetic islet purification.
Fluorine containing bioactive heterocycles. Part<b>II</b>. Synthesis of some new fluorine containing arylglyoxals, their hydrates and 1,5‐disubstituted hydantoins (1981)

Abstract Eight new fluorine containing arylglyoxals have been synthesized by the oxidation of the active methyl group of fluorinated acetophenones by selenium dioxide in dioxan‐water medium. The corresponding hydrates were obtained by dissolving arylglyoxals in minimum amounts of benzene and adding hot water. Seventeen new fluorine containing 1,5‐disubstituted hydantoins were subsequently prepared by the condensation of these arylglyoxals with arylureas in ethanol and characterized by ir, pmr and mass spectral studies. Representative compounds have been screened for their possible anticonvulsant and analgesic activities. None of the compounds show significant analgesic acitivity.
Ingenol Mebutate Gel for Actinic Keratosis (2012)

Ingenol mebutate gel applied topically for 2 to 3 days is effective for field treatment of actinic keratoses. (Funded by LEO Pharma; ClinicalTrials.gov numbers, NCT00742391, NCT00916006, NCT00915551, and NCT00942604.).
Bisphosphonates in the Prevention of Disease Recurrence: Current Results and Ongoing Trials (2009)

Bisphosphonates are the standard of care for preventing skeletal morbidity and treating hypercalcemia of malignancy in patients with bone metastases. Zoledronic acid (intravenous; 4 mg monthly) is approved to prevent skeletal-related events (SREs) in patients with bone metastases from several tumor types, and can improve survival in some subsets of patients with skeletal metastases and high baseline bone turnover. In the adjuvant setting, bisphosphonates have shown clinical efficacy for preventing cancer treatment-induced bone loss and promise for reducing disease recurrence. For example, early studies of clodronate showed the potential for bisphosphonates to prevent bone metastases and prolong survival, but results with clodronate have been inconsistent. Recently, the more active bisphosphonate zoledronic acid (4 mg every 6 months) prevented bone loss and significantly reduced the risk of disease-free survival events by 36% (P = .01) compared with adjuvant endocrine therapy alone in a large phase III trial (N = 1,803) in premenopausal women with early breast cancer. Notably, these benefits were not limited to bone, because the addition of zoledronic acid reduced disease recurrence at all sites. Similarly, twice-yearly zoledronic acid has reduced disease recurrence in large phase III trials in more than 1,600 postmenopausal women with early breast cancer. Several ongoing trials (involving more than 20,000 patients altogether) are evaluating the efficacy of bisphosphonates for prevention of metastases in breast, prostate, and lung cancers; and multiple myeloma. Results from these studies are likely to expand the role of bisphosphonates, especially zoledronic acid, in the adjuvant therapy setting.
Modulation of P‐glycoprotein but not MRP1‐ or BCRP‐mediated drug resistance by LY335979 (2002)

Our study examines the ability of LY335979 (Zosuquidar trihydrochloride) to modulate 3 distinct ABC transporters that are mechanisms of drug resistance: P-glycoprotein (Pgp, ABCB1), multidrug resistance associated protein (MRP1, ABCC2) and breast cancer resistance protein (BCRP, ABCG2). Pgp-mediated resistance can be modulated by coadministration with the highly potent, selective inhibitor, LY335979. Modulation of resistance by mitoxantrone and vinorelbine, 2 drugs used to treat certain solid tumors, was examined in a 3-day cytotoxicity assay using a panel of HL60 leukemia cell lines or MCF-7 breast cancer transfectants. LY335979, at 0.5 microM, substantially reversed mitoxantrone resistance and fully reversed vinorelbine resistance of Pgp-expressing HL60/Vinc cells. However, LY335979 did not modulate drug resistance in the MRP1-expressing HL60/ADR or drug-sensitive parental HL60 cells. To ascertain if LY335979 modulates BCRP-mediated drug resistance, the sensitivity of 26-fold mitoxantrone resistant, BCRP-transfected MCF-7 cells was evaluated. Addition of 5 microM LY335979, a concentration approximately 100-fold higher than the affinity of Pgp, had little to no effect on the BCRP transfectant. [(125)I]Iodomycin photolabeled Pgp in CEM/VLB(100) membranes and was inhibited by 5 microM LY335979 and GF120918. No photolabeling of MRP or BCRP occurred in H69AR or MCF-7/BCRP membranes, respectively. These results further demonstrate that LY335979 is highly specific for Pgp and does not modulate MRP1- or BCRP-mediated resistance and can be used in combination with mitoxantrone and vinorelbine in tumor cells.
A Comparison of High-Level Approaches for Speeding Up Pathfinding (2010)

Most games being shipped today use some form of high-level abstraction such as a navmesh or waypoint graph for path planning. These structures can generally be represented in a form which is compact enough to meet the tight memory constraints in a game. But, when such a graph grows too large, finding paths can still be a complex task. This challenge was faced in Dragon Age: Origins and solved by adding an additional level of abstraction.In the last few years a variety of novel approaches have been developed for finding optimal paths through graphs with specific design applications for road networks. Currently these techniques cannot be feasibly applied to the lowest detail of movement possible in a game map, but can be applied to the high-level abstractions which are commonly found in games.In this paper we describe the pathfinding challenge faced before shipping the title Dragon Age: Origins and perform a postmortem analysis on the extended abstraction that was used in comparison to building more advanced heuristics or the use of contraction hierarchies. We show that contraction hierarchies and abstractions have similar overhead and performance and are both useful approaches for high-level planning in games.
Functional gold nanoparticles for sensing applications (2013)

Abstract Nanoparticle-based technologies have played important roles in providing opportunities for the development of a new generation of sensing tools. Because of their unique optical, chemical, electrical, and catalytic properties, gold nanoparticles (AuNPs) have been extensively studied for biological and chemical detections as well as analytical applications. AuNP-based sensors are expected to change the foundations of sensing and detecting biomolecules and metal ions. The ease of surface functionalization of AuNPs allows chemists to create the desired functionalities for specific applications. In this review, we will discuss the use of surface-functionalized AuNPs for fabricating smart sensors that are capable of detecting heavy metal ions, glucose, and specific biomolecules such as protein and DNA.
Case 35-2002 (2002)

Presentation of CaseA nine-year-old right-handed girl was admitted to the hospital because of a suprasellar mass.The girl had been well, with normal development, until about six months earlier, when her mother observed that she reported “feeling cold” with increasing frequency. During the four months before admission, she reported having impaired vision. Several optometric and ophthalmologic examinations failed to reveal a cause, in great part because the girl was frightened and unable to cooperate fully. At about the same time, her performance at school began to deteriorate dramatically; she reported having severe fatigue and was noted to sleep for . . .
Desktop multimedia communications-breaking the chains (2002)

It is noted that desktop multimedia is achievable today only if it is confined to a single personal computer using direct connections to laser disks, CD-ROMS, and other multimedia data sources. It is suggested that, in order to make multimedia data and services available to individuals connected via local and wide-area networks, special operating system hardware and software are needed. Special network management and services will be required to support bandwidth allocation, time (latency and synchronization) control, and data format conversion. The large bandwidths and real-time characteristics of multimedia affect network requirements. In addition, support in operating system software, dedicated hardware, application interfaces, and new internal buses are required to extend media off of the desktop and into the network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Alkyd-acrylic composite emulsions : polymerization and morphology (1997)

Psychiatric patients given lithium carbonate (LC) commonly develop granulocytosis of the peripheral blood. This is an important observation with several potential applications in clinical hematology and oncology. In order to study further this phenomenon, we have developed an animal model of LC-induced granulocytosis. Four mongrel dogs weighing 23--28 kg were given commercially available LC in 300 mg capsules by mouth twice daily. Peripheral blood was examined twice weekly and marrow granylocyte-committed colony forming units (CFU-c) were studied weekly. Significant increments of peripheral granulocytes (P = 0.003) and of marrow CFU-c (P =0.001) were noted. An increased number of marrow CFU-c has not been previously reported but is consistent with other knowledge about this phenomenon. We conclude that this convenient animal model may be of value in further studies of LC-induced granulocytosis and its possible applications.
An RpoS (σ<sup>S</sup>) homologue regulates acylhomoserine lactone‐dependent autoinduction in <i>Ralstonia solanacearum</i> (1998)

Many bacteria sense an appropriate growth condition or a critical population density for gene expression by producing acylhomoserine lactones (acyl-HSLs) that act as intercellular autoinduction signals. We recently showed that, in Ralstonia (Pseudomonas) solanacearum, a phytopathogenic bacterium, acyl-HSL production requires soll, which encodes a putative acyl-HSL synthase, and that its expression is positively regulated by the acyl-HSL-responsive SolR transcriptional regulator. This acyl-HSL-dependent autoinduction system is noteworthy because (i) it is regulated by a 'higher level' autoinducer system (responsive to 3-hydroxypalmitic acid methyl ester) via PhcA, a LysR-type transcriptional regulator and (ii) acyl-HSL production requires two additional unlinked loci. As reported here, cloning and sequencing of one of these other loci revealed that it encodes a homologue of RpoS, an alternative sigma factor (sigmaS) that in other bacteria activates gene expression during stationary phase or in response to stress conditions. R. solanacearum RpoS (RpoS(Rso)) was demonstrated to function as a sigma factor because when introduced in trans into an Escherichia coli rpoS mutant it largely restored expression of the RpoS-dependent bolAp1 gene. Mutation of rpoS(Rso) in R. solanacearum reduced survival during starvation and low pH conditions, but did not affect survival during exposure to hydrogen peroxide, high osmolarity or high temperature. This mutant was also altered in its production of several virulence factors and wilted tomato plants several days more slowly than the wild-type parent. Transcription of solR and soll were decreased in an rpoS(Rso) background (thereby reducing acyl-HSL production), but neither mutations in solR, soll or phcA nor addition of acyl-HSLs affected rpoS(Rso) expression. Therefore, in R. solanacearum the acyl-HSL-dependent autoinduction system is controlled both by a second autoinduction system and by the RpoS(Rso) sigma factor.
Mechanisms of thyroid hormone action (2012)

Our understanding of thyroid hormone action has been substantially altered by recent clinical observations of thyroid signaling defects in syndromes of hormone resistance and in a broad range of conditions, including profound mental retardation, obesity, metabolic disorders, and a number of cancers. The mechanism of thyroid hormone action has been informed by these clinical observations as well as by animal models and has influenced the way we view the role of local ligand availability; tissue and cell-specific thyroid hormone transporters, corepressors, and coactivators; thyroid hormone receptor (TR) isoform-specific action; and cross-talk in metabolic regulation and neural development. In some cases, our new understanding has already been translated into therapeutic strategies, especially for treating hyperlipidemia and obesity, and other drugs are in development to treat cardiac disease and cancer and to improve cognitive function.
Synthetic peptide-based immunoassay for amino-terminal propeptide of type I procollagen: application for evaluation of bone formation (1993)

Serum biochemical markers are powerful tools for the evaluation of bone turnover. In this study, we developed a radioimmunoassay, using a synthetic peptide for the N-terminal fragment of human type I [alpha 1(I)] procollagen (N-PCP). A 14-amino acid peptide was synthesized from the amino terminus and used to generate antibodies in rabbits. The synthetic peptide was used as standard and tracer in the assay. Both native type I amino procollagen (PINP), which was purified from skin fibroblasts, and human serum displaced tracer binding in parallel with the synthetic peptide. The range for measurement of N-PCP in serum was 0.7 to 30 micrograms/L (0.21-9.18 nmol/L). In a sample of 17 normal adults and 13 children (ages 9-16 years) there was a strong correlation between serum N-PCP determined by this assay and both skeletal alkaline phosphatase isoenzyme and osteocalcin, markers of bone formation. Serum concentrations of N-PCP in a group of normal children were eightfold higher than concentrations in normal adults, with no overlap between the two groups. N-PCP also correlated with C-terminal type I procollagen determined with a commercially available kit (r = 0.92).
Short Overview of Early Developments of the Hardy Cross Type Methods for Computation of Flow Distribution in Pipe Networks (2019)

Hardy Cross originally proposed a method for analysis of flow in networks of conduits or conductors in 1936. His method was the first really useful engineering method in the field of pipe network calculation. Only electrical analogs of hydraulic networks were used before the Hardy Cross method. A problem with flow resistance versus electrical resistance makes these electrical analog methods obsolete. The method by Hardy Cross is taught extensively at faculties, and it remains an important tool for the analysis of looped pipe systems. Engineers today mostly use a modified Hardy Cross method that considers the whole looped network of pipes simultaneously (use of these methods without computers is practically impossible). A method from a Russian practice published during the 1930s, which is similar to the Hardy Cross method, is described, too. Some notes from the work of Hardy Cross are also presented. Finally, an improved version of the Hardy Cross method, which significantly reduces the number of iterations, is presented and discussed. We also tested multi-point iterative methods, which can be used as a substitution for the Newton–Raphson approach used by Hardy Cross, but in this case this approach did not reduce the number of iterations. Although many new models have been developed since the time of Hardy Cross, the main purpose of this paper is to illustrate the very beginning of modeling of gas and water pipe networks and ventilation systems. As a novelty, a new multi-point iterative solver is introduced and compared with the standard Newton–Raphson iterative method.
Robust license plate detection in the wild (2017)

License Plate Detection (LPD) is the pivotal step for License Plate Recognition. In this work, we explore and customize state-of-the-art detection approaches for exclusively handling the LPD in the wild. In-the-wild LPD considers license plates captured in challenging conditions caused by bad weathers, lighting, traffics, and other factors. As conventional methods failed to handle these inevitable conditions, we explore the latest deep learning based detectors, namely YOLO (You-Only-Look-Once) and its variant YOLO-9000 (referred here as YOLO-2), and customize them for effectively handling the LPD. The prime customizations include modification of the grid size and of the bounding box parameter estimation, and the composition of a more challenging AOLPE (Application-Oriented License Plate Extended) database for performance evaluation. The AOLPE database is an extended version of the AOLP database [1] with additional images taken under extreme but frequently-encountered conditions. As the original YOLO and YOLO-2 are not designed for the LPD, they failed to handle the LPD on the AOLPE without the customizations. This study can be one of the pioneering works that revise state-of-the-art real-time deep networks for handling the LPD. It also serves as a case study for those who wish to customize existing deep networks for detecting specific objects. In addition to a pioneering explorations of deep networks for handling the in-the-wild LPD, our contribution also includes the release of the AOLPE database and evaluation protocol for a novel benchmark for the LPD.
Effects of short‐term endurance exercise on gut microbiota in elderly men (2018)

Regular exercise reduces the risks for cardiovascular diseases. Although the gut microbiota has been associated with fitness level and cardiometabolic risk factors, the effects of exercise-induced gut microbiota changes in elderly individuals are unclear. This study evaluated whether endurance exercise modulates the gut microbiota in elderly subjects, and whether these changes are associated with host cardiometabolic phenotypes. In a randomized crossover trial, 33 elderly Japanese men participated in a 5-week endurance exercise program. 16S rRNA gene-based metagenomic analyses revealed that the effect of endurance exercise on gut microbiota diversity was not greater than interindividual differences, whereas changes in α-diversity indices during intervention were negatively correlated with changes in systolic and diastolic blood pressure, especially during exercise. Microbial composition analyses showed that the relative abundance of Clostridium difficile significantly decreased, whereas that of Oscillospira significantly increased during exercise as compared to the control period. The changes in these taxa were correlated with the changes in several cardiometabolic risk factors. The findings indicate that short-term endurance exercise has little effect on gut microbiota in elderly individuals, and that the changes in gut microbiota were associated with cardiometabolic risk factors, such as systolic and diastolic blood pressure, providing preliminary insight into the associations between the gut microbiota and cardiometabolic phenotypes.
Immunization with a Lentiviral Vector Stimulates both CD4 and CD8 T Cell Responses to an Ovalbumin Transgene (2005)

Lentiviral vectors encoding antigens are promising vaccine candidates because they transduce dendritic cells (DC) in vivo and prime CTL responses. Here we examine their stimulation of antigen-specific CD4(+) T cells, critical for protective immunity against tumors or infectious disease. We constructed lentiviral vectors (lentivectors) expressing ovalbumin, which was secreted (OVA), cytoplasmic (OVAcyt), or fused to either invariant chain (Ii-OVA) or transferrin receptor (TfR-OVA) sequences, targeting the MHC class II presentation pathway. Murine DC infected with the various lentivectors could stimulate OT-I (CD8(+), OVA TCR transgenic) T cells and all except OVAcyt could also stimulate OT-II (CD4(+), OVA TCR transgenic) T cells in vitro. Direct injection of the OVA-, Ii-OVA-, or TfR-OVA-expressing vectors into mice resulted in a CD4(+) T cell response, as shown by expansion of adoptively transferred OT-II T cells and upregulation of CD44 on these cells. The Ii-OVA vector was the most potent inducer of IFN-gamma-secreting CD4(+) and CD8(+) T cells and was the only vector to protect mice completely from challenge with OVA-expressing tumor cells. Therefore directly injected lentivectors can stimulate CD4(+) T cells; both CD4(+) and CD8(+) responses can be enhanced by targeting the antigen to the MHC class II pathway.
Finite element analysis of static and dynamic properties of the masonry chimney (2010)

With the help of the ANSYS software,a finite element model is established for a kind of masonry chimney in this paper.Taken into full considerations of the actual conditions of masonry structure bearing,the representative volume element method is applied in the analyses of masonry chimney's static and dynamic characteristics.The model then is compared with the theoretical calculation results,which provides theoretical basis for the reinforcement of the existing masonry chimney.
Hatchablility of Broiler Breeder Eggs Sanitized with a Combination of Ultraviolet Light and Hydrogen Peroxide* (2011)

Research has shown that exterior eggshell Aerobic Plate Counts (APC) are greatly decreased using a combination of Ultraviolet Light (UV) and hydrogen peroxide (H2O2). However, it is unknown how this treatment process would impact hatchability. Therefore, the objective of this experiment was to determine if spraying eggs with 1.5% H2O2 followed by UV irradiation for 8 min to reduce eggshell APC would affect hatchability. Eggs from 3 commercial houses (57 wk-old broiler breeders) were collected over 2 d (n = 1,944 eggs). Half were treated with 1.5% H2O2 and UV and the other half served as untreated controls (18 eggs/ tray). At time of treatment, 1 egg was randomly selected from each of 108 trays (n = 54 per treatment) for eggshell APC enumeration on TSA. Remaining eggs were stored at 18.3 C. Prior to set, 1 egg per tray from o d 1 of collection was sampled for APC enumeration. The 16 remaining eggs/tray were weighed prior to incubation and at 18 d to determine egg weight loss. At hatch (21.5 d), chick weights were obtained, meconium samples were collected from 18 chicks per incubator and samples were plated on TSA to determine the presence of intestinal microorganisms. A 3 log10CFU/egg reduction in eggshell APC was found for treated eggs when compared to control eggs. At hatch, no differences in chick weight, egg weight loss, positive meconium samples, or hatchability were observed between treatments. In conclusion, UV irradiation for 8 min with 1.5% H2O2 reduced eggshell APC on broiler breeder eggs with no affect on hatchability.