gebhart/patrepeval huggingface dataset:
Pancreas development in health and disease (2010)

Diabetes is the most frequent endocrine disease in the pediatric population. The prevalence of both, type 1 and type 2 diabetes is increasing worldwide every year. The prevalence under age 15 years is predicted to rise in Europe by 70% between 2005 and 2020. Diabetes type 2, most often associated with obesity, is increasing rapidly as well and represents today between 8 and 43% of new-onset diabetes cases in children depending on geographic location. While in type 1 diabetes insulin-producing beta cells are destroyed, insulin resistance, followed by beta cell failure, characterizes diabetes type 2. Type 2 diabetes is associated with several environmental factors, the most important being obesity. Both, type 1 and type 2 diabetes are of polygenic origin. Over 40 distinct genomic locations have been associated with diabetes type 1. Recently, monogenic forms of diabetes, caused by a single gene defect in the beta cell machinery, are more often diagnosed due to new molecular insights into beta cell function and the possibility of genetic analyses, indispensable for diagnosis. Of all diabetic patients, 2% to 5% are thought to have a monogenic origin, affecting approximately 9,000 to 15,000 persons in Switzerland alone and four to ten millions worldwide. The fraction of underdiagnosed cases of monogenic diabetes is even higher in children and could represent up to 10% children with diabetes. Today the majority of these cases are missed, and there is an urgent need for better diagnostic tools. Understanding the complexity of transcriptional regulation in pancreas development constitutes the basis for the comprehension of beta cell physiology and several monogenic forms of diabetes. Mouse models provide insight into the underlying mechanisms of the development of diabetes. These transcription factors may also be promising candidates in future therapeutic approaches with the ultimate goal to cure diabetes. The identification of the genes involved is of outmost importance for the patient, since it will determine the choice of treatment and will allow for a more precise estimate of the risk for long-term complications. As several forms of monogenic diabetes can be treated with oral drugs, and multiple daily insulin injections are no longer needed, the accurate diagnosis may significantly improve metabolic control and the patient's quality of life.
A robust audio fingerprinting method using spectrograms saliency maps (2014)

Audio fingerprinting is widely used for audio identification, indexing, searching, navigation, monitoring and other monetization purposes, as well as support to other areas such as watermarking, music information retrieval and video identification. Because the ease of distorting intentionally or unintentionally an audio signal, the robustness and accuracy are very important characteristics in audio fingerprinting to avoid false alarm errors. In this paper, an audio fingerprinting method is proposed, it uses the spectrogram representation of an audio signal, combined with a global fingerprint extraction. The fingerprint extraction is based on the saliency maps of the spectrogram of the audio signal. The proposed method is robust against common signal processing attacks, colored noise addition and severe temporal desynchronization attacks, e.g. time shifting, pitch shifting and speed change.
Avatrel dielectric polymers for HDP applications (1999)

In order to realize the performance advancements in silicon technology, complementary advances in packaging technology are necessary. Advance materials must be developed to achieve the full potential of advance packaging processes. A family of dielectric polymers based on polynorbornene is under development to address the broad needs of high density packaging (HDP). Properties common to this family of materials include a low dielectric constant, low loss tangent, low moisture absorption, good adhesion, and isotropic properties. This family's tailorability allows materials to be developed for a number of applications including wafer redistribution, passivation, sequential, and parallel build-up processes.
Pengaruh Brand Images dan Kualitas Produk Sepatu Adidas NMD Terhadap Keputusan Pembelian (2017)

Penelitian ini membahas tentang pengaruh brand images dan kualitas produk terhadap keputusan pembelian mahasiswa/mahasiswi di Universitas Tarumanagara dan Universitas Kwik Kian Gie. Penulis memilih produk sepatu Adidas Nmd karena sepatu ini menjadi Brand images bagi remaja sekarang dan kualitas yang tidak diragukan lagi dan menjadi sepatu memenuhi gaya hidup remaja pada masa kini. Penulis memilih Universitas Tarumanagara dan Universitas Kwik Kian Gie dikarenakan kedua Universitas ini merupakan Universitas yang mahasiswa ataupun mahasiswinya memperhatikan fashion era modern. Penelitian ini menggunakan metode penelitian kuantitatif. Teknik pengumpulan data melalui penyebaran kuesioner melalui nonprobability sampling . Hasil penelitian ini pengaruh tinggi terhadap ketiga variabel, diperoleh hasil  R (0.718) bahwa terdapat pengaruh yang kuat dalam ketiga variabel karena berada pada interval 0,6-0,79. maka dapat dikatakan bahwa terdapat  pengaruh brand images dan kualitas produk sepatu Adidas Nmd terhadap ( studi keputusan pembelian mahasiswa  Universitas Tarumangara dan Universitas Kwik Kian Gie).
Trends in Alternative Medicine Use in the United States, 1990-1997 (1999)

Eisenberg, David M.; Davis, Roger B.; Ettner, Susan L.; Appel, Scott; Wilkey, Sonja; Van Rompay, Maria; Kessler, Ronald C. Author Information
Targeting Multiple Signaling Pathways by Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate (2006)

Cell signaling pathways, responsible for maintaining a balance between cell proliferation and death, have emerged as rational targets for the management of cancer. Emerging data amassed from various laboratories around the world suggests that green tea, particularly its major polyphenolic constituent (-)-epigallocatechin-3-gallate (EGCG), possesses remarkable cancer chemopreventive and therapeutic potential against various cancer sites in animal tumor bioassay systems and in some human epidemiologic studies. EGCG has been shown to modulate multiple signal transduction pathways in a fashion that controls the unwanted proliferation of cells, thereby imparting strong cancer chemopreventive as well as therapeutic effects. This review discusses the modulations of important signaling events by EGCG and their implications in cancer management.
An Overview of Immunologic Adjuvants - A Review (2012)

With the onset of antigen production using biosynthetic and rDNA techniques, the need to administer adjuvants along with vaccines has increased remarkably. This search for accompanying adjuvants has resulted in a multitude of molecules from mineral salts to bacterial polysaccharides and Immuno stimulatory complexes that range considerably in efficacy. Moreover, the adjuvant molecule is specific to its antigen molecule and hence has to be tailored suitably to maximise efficacy and safety, maintaining the cost at a minimum. This paper explores the characteristics of these molecules, their mode of action and the advancements in the field.
<i>n</i>→π* Interactions of Amides and Thioamides: Implications for Protein Stability (2013)

Carbonyl-carbonyl interactions between adjacent backbone amides have been implicated in the conformational stability of proteins. By combining experimental and computational approaches, we show that relevant amidic carbonyl groups associate through an n→π* donor-acceptor interaction with an energy of at least 0.27 kcal/mol. The n→π* interaction between two thioamides is 3-fold stronger than between two oxoamides due to increased overlap and reduced energy difference between the donor and acceptor orbitals. This result suggests that backbone thioamide incorporation could stabilize protein structures. Finally, we demonstrate that intimate carbonyl interactions are described more completely as donor-acceptor orbital interactions rather than dipole-dipole interactions.
Blood Contamination of Anesthesia Equipment and Monitoring Equipment (1994)

This study was conducted to determine the extent of blood contamination of anesthesia equipment and monitoring equipment in clinical use in operating rooms. The study employed a catalytic-test method, which is used in forensic medicine, to detect blood contamination of anesthesia equipment and monitoring equipment. Nineteen definable surfaces were sampled in 22 operating rooms. Thirty-three percent of surfaces were contaminated with blood. Contaminated equipment included surfaces that are in continuous contact with patients, e.g., blood pressure cuffs and pulse oximeter probes. Visual inspection was not a reliable means of detecting blood contamination. Whether this blood contamination represents an infection risk was not determined. Nevertheless, improved cleaning and disinfection procedures are probably needed. Equipment design needs to focus on reducing the potential for blood contamination and enhancing capability for cleaning and disinfection.
Étude expérimentale du mode de repliement β dans quelques molécules tripeptidiques modèles. Interprétation des spectres d’absorption infrarouge (1974)

Par spectrométrie infrarouge, on a étudié les conformations prises, dans un milieu inerte comme le tétrachlorure de carbone, par des molécules modèles tripeptidiques de formule générale R — CO — Pro — Y — NH — R’ associant un segment proline à un second résidu amino-acide Y asymétrique (alanine) ou achiral (glycine ou acide α-amino-isobutyrique).
Image Prediction for Limited-angle Tomography via Deep Learning with Convolutional Neural Network (2016)

Limited angle problem is a challenging issue in x-ray computed tomography (CT) field. Iterative reconstruction methods that utilize the additional prior can suppress artifacts and improve image quality, but unfortunately require increased computation time. An interesting way is to restrain the artifacts in the images reconstructed from the practical filtered back projection (FBP) method. Frikel and Quinto have proved that the streak artifacts in FBP results could be characterized. It indicates that the artifacts created by FBP method have specific and similar characteristics in a stationary limited-angle scanning configuration. Based on this understanding, this work aims at developing a method to extract and suppress specific artifacts of FBP reconstructions for limited-angle tomography. A data-driven learning-based method is proposed based on a deep convolutional neural network. An end-to-end mapping between the FBP and artifact-free images is learned and the implicit features involving artifacts will be extracted and suppressed via nonlinear mapping. The qualitative and quantitative evaluations of experimental results indicate that the proposed method show a stable and prospective performance on artifacts reduction and detail recovery for limited angle tomography. The presented strategy provides a simple and efficient approach for improving image quality of the reconstruction results from limited projection data.
Interactions between drugs and plastic intravenous fluid bags, part ii: leaching of chemicals from bags containing various solvent media (1974)

The UV absorption spectra of various solvent media stored in commercial polyvinyl chloride (PVC) intravenous fluid bags were scanned to study the leaching of chemicals from the plastic bags. Absorbances of media such as distilled water, normal saline, 5% dextrose solution, 5% alcohol solution, and aqueous buffer solutions with pH ranging from 3.5 to 9.5 were all quite low within 48 hours of study, indicating insignificant leaching of UV-absorbing materials. Ahsorbances from 0.01 to 0.04% of Tween 20 and 80 solutions were quite high, indicating leaching of a significant amount of chemical(s) from the bags. Effects of surfactant concentration and storage time on the leaching were also studied. The preliminary study indicated that the plasticizer, di-2-ethylhexyl phthalate, or other type of phthalate plasticizer may he a major leached chemical.
Sensor-Based Physiologic Control Strategy for Biventricular Support with Rotary Blood Pumps (2017)

Rotary biventricular assist devices (BiVAD) are becoming a clinically accepted treatment option for end-stage biventricular failure. To improve BiVAD efficacy and safety, we propose a control algorithm to achieve the clinical objectives of maintaining left-right-sided balance, restoring physiologic flows, and preventing ventricular suction. The control algorithm consists of two proportional-integral (PI) controllers for left and right ventricular assist devices (LVAD and RVAD) to maintain differential pump pressure across LVAD (ΔPL) and RVAD (ΔPR) to provide left-right balance and physiologic flow. To prevent ventricular suction, LVAD and RVAD pump speed differentials (ΔRPML, ΔRPMR) were maintained above user-defined thresholds. Efficacy and robustness of the proposed algorithm were tested in silico for axial and centrifugal flow BiVAD using 1) normal and excessive ΔPL and/or ΔPR setpoints, 2) rapid threefold increase in pulmonary vascular or vena caval resistances, 3) transient responses from exercise to rest, and 4) ventricular fibrillation. The study successfully demonstrated that the proposed BiVAD algorithm achieved the clinical objectives but required pressure sensors to continuously measure ΔPL and ΔPR. The proposed control algorithm is device independent, should not require any modifications to the pump or inflow/outflow cannulae/grafts, and may be directly applied to current rotary blood pumps for biventricular support.
Long‐term effects of systemic gene therapy in a canine model of myotubular myopathy (2017)

AAV-mediated gene transfer of MTM1 in young XLMTM dogs results in long-term expression of myotubularin transgene with normal muscular performance and neurological function in the absence of muscle pathology. These findings support a clinical trial in patients. Muscle Nerve 56: 943-953, 2017.
Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease (2013)

The present study shows that patients with mild AD evidenced marked alterations in eye movement behavior during reading, even at early stages of the disease. Hence, evaluation of eye movement behavior during reading might provide a useful tool for a more precise early diagnosis of AD and for dynamical monitoring of the pathology.
CI.—Researches on the constitution of physostigmine. Part I (1912)

A. H. Salway, J. Chem. Soc., Trans., 1912, 101, 978 DOI: 10.1039/CT9120100978
Wireless ATM LAN with and without infrastructure (1998)

We consider wireless ATM concepts for small LANs, especially for SOHO and future consumer applications. We describe a wireless ATM LAN framework architecture that supports wireless ATM communications in environments with and without fixed ATM infrastructure. For the configuration with an ATM infrastructure, a distributed ATM switched backbone is proposed, which enables a smart ATM switching element to be embedded in every wireless and fixed access point. For bandwidth efficiency and ease of operation (place-and-play), we also propose an ad hoc wireless ATM LAN concept based on the same 5 GHz wireless ATM air interface as is currently under standardization in the ETSI/BRAN and ATM Forum. Unlike CSMA-based ad hoc systems such as HIPERLAN and IEEE802.11, our ad hoc wireless ATM system makes QoS management feasible in an infrastructureless environment by using resource reservation and scheduled medium access protocol. Since cost scalability is essential throughout our system design, we consider forwarding between ad hoc subnets and interworking with the fixed network as important but optional features.
Modeling of Emergency Diesel Generator and Governor Transient Response Using MATLAB/SIMULINK (1995)

<div class="htmlview paragraph">The use of graphical dynamic system simulation software is becoming more popular as economic demands require reducing time and cost of development and troubleshooting equipment. Nuclear power plants pose unique problems in this regard because installed equipment must be available to support the plant safety function, so it is not available to support qualification testing of new designs or troubleshooting in the case of equipment malfunction. Commercial design processes have similar constraints due to the high cost of prototype development.</div> <div class="htmlview paragraph">This paper discusses recent successes in using modular system simulation software to support the implementation of improved speed control governors installed on emergency diesel generators. The original governors are to be replaced as part of an overall control system upgrade. However, the engine operator needed to demonstrate that the replacement governors would provide adequate transient performance and no degradation in engine or generator response during fast loading and full load rejection per United States Nuclear Regulatory Commission (USNRC) Regulatory Guide 1.9. A dynamic system model was developed using MATLAB/SIMULINK software, which the authors have used in other similar modeling tasks. The system model includes a torque-predictive engine model (including sub-models of the turbocharger and fuel injection system), speed control governor, and plant emergency electrical loads. This model was validated using the engine vendor's qualification test stand data and results from periodic utility surveillance tests.</div> <div class="htmlview paragraph">Through use of the model, the performance of the EDGs with replacement governors was predicted to be the same as with the original governors. In addition, it was shown that the performance could be enhanced to comply with the intent of the regulatory guide. Further, by using the model, stability and tuning analyses were accomplished to predict the system adjustments required prior to installation, thus reducing the time to implement the modification. Finally, a modified governor system design was analyzed to determine if improved system response could be attained.</div>
Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut (1998)

Indirect fluorescent-antibody (IFA) staining methods with Ehrlichia equi (MRK or BDS strains) and Western blot analyses containing a human granulocytic ehrlichiosis (HGE) agent (NCH-1 strain) were used to confirm probable human cases of infection in Connecticut during 1995 and 1996. Also included were other tests for Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis (HME), Babesia microti, and Borrelia burgdorferi. Thirty-three (8.8%) of 375 patients who had fever accompanied by marked leukopenia or thrombocytopenia were serologically confirmed as having HGE. Western blot analyses of a subset of positive sera confirmed the results of the IFA staining methods for 15 (78.9%) of 19 seropositive specimens obtained from different persons. There was frequent detection of antibodies to a 44-kDa protein of the HGE agent. Serologic testing also revealed possible cases of Lyme borreliosis (n = 142), babesiosis (n = 41), and HME (n = 21). Forty-seven (26.1%) of 180 patients had antibodies to two or more tick-borne agents. Therefore, when one of these diseases is clinically suspected or diagnosed, clinicians should consider the possibility of other current or past tick-borne infections.
Phosphodiesterase 5 inhibition restores impaired ACh relaxation in hypertensive conduit pulmonary arteries (2001)

Responses to acetylcholine (ACh) and sodium nitroprusside (SNP) were compared in large (LPA) and small pulmonary artery (SPA) rings from normoxic and chronically hypoxic (CH) rats. In addition, the effects of a selective phosphodiesterase (PDE) 5 inhibitor, E-4021, on ACh-induced relaxation were evaluated. Chronic hypoxia markedly decreased both ACh- and SNP-induced relaxations in LPA but not in SPA rings. Pretreatment with E-4021 caused a much greater leftward shift of the concentration-response curve for ACh in hypoxic than in normoxic LPA rings, eliminating the difference in response to ACh between these two vessels. These results suggest that cGMP-dependent relaxation is impaired in the proximal but not in the distal pulmonary artery of CH rats and that increased PDE5 activity could be a mechanism responsible for this impaired responsiveness.
Implementation and Analysis of a Parallel Collection Query Language (1996)

We study implementation techniques for a parallel query language for nested collections. The language handles collections of three kinds (sets, bags, and sequences), and its expressive power is essentially that of OQL (ODMG93). From the perspective of parallel evaluation, the novelty of such a query language is that it can express nested parallelism, which is naturally associated to nested collections. The first implementation step is a translation into a specially designed algebra for flat sequences, having only flat parallelism: the translation &quot;flattens&quot; the nested parallelism, and we prove that it preserves the asymptotic parallel complexity. The second step consists in an implementation of the sequence algebra on a shared nothing architecture. Here we show that all data communications needed by the sequence algebra operators (with one exception) have a particular communication pattern, called monotone communication. We give a provably optimal algorithm for monotone communications ...
Nonlinear processing of auditory brainstem response (2005)

Auditory brainstem response potentials (ABR) are signals calculated from the EEG signals registered as responses to an acoustic activation of the auditory system. The ABR signals provide an objective, diagnostic method, widely applied in examinations of hearing organs. The shape of the time-dependent signal, and its possible distortion, and particularly the presence or absence of characteristic waves are of great diagnostic importance. In the present work methods of automated identification of wave V are presented, using multilayer perceptron type networks. Classification methods are also proposed, based on cascade architecture of the neural networks used for recognition of the context information.
Fluorescence and EPR Characteristics of Mn<sup>2+</sup>-Doped ZnS Nanocrystals Prepared by Aqueous Colloidal Method (1999)

Fluorescence properties have been studied for Mn:ZnS crystallites with average diameter of 4 nm prepared by an aqueous colloidal method under 266 nm light excitation. The intensity ratio of the blue band at ∼430 nm to the orange band at ∼590 nm has decreased after the preparation on a time scale of hours in aqueous solution. On the other hand, hyperfine structures of Mn2+ in the electron paramagnetic resonance spectrum have increased markedly on the same time scale in solution samples. These phenomena are attributed to the redistribution of defect centers in nanocrystals. Such phenomena have not been observed in samples incorporated into poly(vinyl alcohol). The orange emission is mainly due to the 6A1 ← 4T1 transition of Mn2+, while the blue emission is tentatively assigned to the donor−acceptor pair transition in which the acceptor is related to the Zn2+ vacancy. Fluorescence decay times of the blue and orange bands have been found to be ∼10 ns and ∼1 ms, respectively, the latter being the same as in the bulk samples. A weak fluorescent component with fast kinetics observed in the orange region has been identified as a tail of the blue band. No lifetime shortening of the Mn2+ emission due to quantum confinement has been observed, contrary to reports in the literature.