gebhart/patrepeval huggingface dataset:
Ultrasound in phosphine preparation. Simple preparations of some bis(alkylphenylphosphino)alkanes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltrasound in phosphine preparation. Simple preparations of some bis(alkylphenylphosphino)alkanesTashue Chou, Chunghuang Tsao, and Su Chun HungCite this: J. Org. Chem. 1985, 50, 22, 4329–4332Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://doi.org/10.1021/jo00222a025RIGHTS & PERMISSIONSArticle Views296Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (482 KB) Get e-Alertsclose Get e-Alerts
The implementation of a natural admittance controller on an industrial manipulator (2002)

This research focuses on the implementation of a natural admittance controller on an industrial manipulator. Natural admittance control is a particular type of interaction controller which guarantees stability with any passive environment. The admittance criterion is presented along with methods of control. A robot model is proposed and the model parameters are found experimentally. A controller is designed which takes into consideration the aforementioned model. Also, a convenient technique that allows "on the fly" modification of controller gains and desired dynamics has been developed. The controller was designed and implemented on an industrial robot and performance results are presented. The implemented scheme is shown to offer high performance and guaranteed stability with good friction rejection.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection (2012)

SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist. It is efficacious in multiple preclinical disease models. These results demonstrate that therapy with CXCR3 antagonists may serve as a new strategy for treatment of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, and to prevent transplant rejection.
Visualising sequences of queries: a new tool for information retrieval (2002)

This paper describes a system that uses visualisation to assist a user in dealing with the information returned from a search engine. The user's queries, and the documents they return, are represented by a 3D spatial structure that shows their relationships and provides a way of accessing and exploring the documents retrieved. It is implemented to work with the New Zealand Digital Library, a set of large document collections that is available over the Web. The visualisation scheme is a Java applet that is updated dynamically whenever the user makes a new search, and can be browsed alongside the search engine.
Helminths in moose of Alberta (1976)

Sixteen species of helminths (five cestodes, eight nematodes, and three trematodes) were found during examination of 215 moose from Alberta. Different helminth faunas occurred in moose from the major population in the west and north, and from isolated populations in central (Elk Island National Park) and southeastern (Cypress Hills Provincial Park) Alberta; only Moniezia sp., Taenia hydatigena, and Nematodirella longispiculata were found in all three populations. Thysanosoma actinioides, Protostrongylus macrotis, Setaria labiatopapillosa, Fascioloides magna, and Zygocotyle lunata were found in only one of the three populations; their presence was most likely due to cohabitation by moose and other infected vertebrates. The presence of wolves probably accounted for the high prevalence of Echinococcus granulosus, T. hydatigena, and Taenia krabbei in the west and north, while coyotes were of local importance in maintenance of E. granulosus and T. hydatigena in the park populations. Wehrdikmansia cervipedis was not found in park populations probably because of absence or scarcity of the intermediate host. Moniezia expansa, P. macrotis, S. labiatopapillosa, and Z. lunata are reported for the first time from moose in North America.
Novel Gate-Protection Devices for MOSFET's (1983)

Novel gate-protection devices for vertical-type power MOSFET's are developed utilizing a poly-Si film on an insulator. It is shown experimentally that, a breakdown voltage higher than 20 V, a leakage current of about 0.1 A/cm 2 , and a destructive breaking strength more than 300 V satisfy specifications for gate-protection devices. Power MOSFET's with the gate-protection device show remarkably reduced gate short characteristics against a simulated static discharge. These latch-up free, gate-protection devices should prove very useful for every type of MOS device.
Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of<i>Plasmodium falciparum</i>merozoites (2003)

Apical membrane antigen 1 (AMA-1) is a promising vaccine candidate for Plasmodium falciparum malaria. Antibodies against AMA-1 of P. falciparum (PfAMA-1) interrupt merozoite invasion into RBCs. Initially localized within the apical complex, PfAMA-1 is proteolytically processed and redistributed circumferentially on merozoites at about the time of their release and invasion into RBCs. An 83-kDa precursor form of PfAMA-1 is processed to 66-kDa and then to 48- and 44-kDa products. We show that, even at low concentrations, IgG antibodies against correctly folded recombinant PfAMA-1 cross-linked and trapped the 52-, 48-, and 44-kDa proteolytic products on merozoites. These products are normally shed into the culture medium. At higher concentrations antibodies inhibited invasion into RBCs and caused a reduction in the amount of 44- and 48-kDa products, both on merozoites and in the culture medium. A corresponding increase also occurred in the amount of the 66- and 52-kDa forms detected on the merozoites. These antibodies also prevented circumferential redistribution of AMA-1. In contrast, monovalent invasion-inhibitory Fab fragments caused accumulation of 66- and 52-kDa forms, with no cross-linking, trapping, or prevention of redistribution. Antibodies at low concentrations can be used as trapping agents for intermediate and soluble forms of AMA-1 and are useful for studying proteolytic processing of AMA-1. With this technique, it was confirmed that protease inhibitor chymostatin and Ca2+ chelators can inhibit the breakdown of the 66-kDa form. We propose that antibodies to AMA-1 capable of inhibiting erythrocyte invasion act by disrupting proteolytic processing of AMA-1.
Strong measurement and quantum feedback for persistent Rabi oscillations in circuit QED experiments (2012)

We investigate the stabilization of the dynamical state of a superconducting qubit. In a series of papers, A. Korotkov and his co-workers suggested that continuous weak measurement of the state of a qubit and applying an appropriate feedback on the amplitude of a Rabi drive, should maintain the coherence of the Rabi oscillations for arbitrary time. Here, in the aim of addressing a metrological application of these persistent Rabi oscillations, we explore a new variant of such strategies. This variant is based on performing strong measurements in a discrete manner and using the measurement record to correct the phase of the Rabi oscillations. Noting that such persistent Rabi oscillations can be viewed as an amplitude-to-frequency convertor (converting the amplitude of the Rabi microwave drive to a precise frequency), we propose another feedback layer consisting of a simple analog phase locked loop to compensate the low frequency deviations in the amplitude of the Rabi drive.
Co-stimulation of T cells results in distinct IL-10 and TNF-α cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3 (1999)

The LFA-1 adhesion molecule is involved in cell adhesion events of leukocytes through binding to ICAM-1, ICAM-2 and ICAM-3. Whether binding to either of these ligands similarly affects co-stimulation of T cells and cytokine secretion is unknown. We demonstrated that LFA-1 co-stimulation under suboptimal concentrations of anti-CD3 monoclonal antibodies resulted in high, intermediate and weak proliferation of T cells on ICAM-1, -2, and -3, respectively, which correlates with the distinct affinities of LFA-1 for these ligands. Furthermore, we investigated whether binding to ICAM-1, -2 or -3 induced different cytokine profiles, thus regulating T helper cell function. Granulocyte-macrophage colony-stimulating factor and IFN-gamma were secreted in high amounts, whereas IL-2, IL-4 and IL-5 could not be detected. Interestingly, we observed that LFA-1/ICAM-1 co-stimulation of T cells resulted in high production of the Th2 cytokine IL-10 compared to ICAM-2 or ICAM-3 co-stimulation. In contrast, ICAM-2 and ICAM-3 induced a much stronger secretion of the Th1 cytokine TNF-alpha compared to LFA-1/ICAM-1 induced co-stimulation, despite the lower proliferation rate. These results demonstrate that besides facilitating cell adhesion, LFA-1 serves as a potent co-stimulatory molecule by inducing different cytokine patterns depending on the ligand bound.
USE OF THE NANODIAMONDS IN BIOMEDICINE (2015)

The aim of this work is to summarize the literature data concerning the strategy of creating of methods of efficient nanotherapy and targeted drug delivery. It was shown that the developed methods of post-refining, control surface cleanliness and creating different types of hydrophilic surface of nanodiamonds provide ample opportunities for high-quality surface functionalization of organic compounds. Modern direction of nanomedicine is creation of complex biocompatible nanomaterials with antitumor activity that promote the targeted drug transport in the place of localization of pathological process. To provide targeted drug delivery C60-fullerens, nanoporous silica, carbon nanotubes and nanodiamonds are widely used. The combination of nanodiamonds with other nanoparticles and their association with drugs can be considered as a promising strategy to overcome tumor resistance to the drug action. It can be suggested that nanodiamonds coated with polyethylene glycol is the way to create the stable and selective carriers of new types. They have to be biocompatible, stable, possess higher dispersion in biological media and avoid recognition by the immune system. Such composites effectively enter the cell cytoplasm via clathrin –mediated endocytosis. Hybrid nanocarriers will become the basis for the targeted and controlled release of high concentrations of antineoplastic chemoterapeutic agents within the cytosol of the cancer cells with minimal non-specific binding and toxicity towards normal cells.
Analysis and development of Java Grande benchmarks (1999)

Understanding the performance behaviour of Java Virtual Machines is important to Java systems developers and to applications developers. We review a range of Java benchmark programs, including those collected by the Java Grande Forum as useful performance indicators for large-scale scientific applications, or “Java Grande applications”. We systematically analyse these benchmarks on a collection of compute platforms including Pentium II, UltraSPARC II, Silicon Graphics, iMac and Alpha, and operating systems including Windows NT, Solaris, and Linux, and consider differences in performance between benchmarks running on the Java Development Kit (JDK) versions 1.1.6 and 1.2. We also analyse some benchmark programs we have developed to augment existing collections. We observe some general trends in the performance of Java on various platforms and also conduct some comparisons between benchmarks written in Java and in traditional languages such as C and Fortran. We discuss performance variations across systems and the implications of Java systems performance for those developing scientific applications.
Curation accuracy of model organism databases (2014)

Manual extraction of information from the biomedical literature-or biocuration-is the central methodology used to construct many biological databases. For example, the UniProt protein database, the EcoCyc Escherichia coli database and the Candida Genome Database (CGD) are all based on biocuration. Biological databases are used extensively by life science researchers, as online encyclopedias, as aids in the interpretation of new experimental data and as golden standards for the development of new bioinformatics algorithms. Although manual curation has been assumed to be highly accurate, we are aware of only one previous study of biocuration accuracy. We assessed the accuracy of EcoCyc and CGD by manually selecting curated assertions within randomly chosen EcoCyc and CGD gene pages and by then validating that the data found in the referenced publications supported those assertions. A database assertion is considered to be in error if that assertion could not be found in the publication cited for that assertion. We identified 10 errors in the 633 facts that we validated across the two databases, for an overall error rate of 1.58%, and individual error rates of 1.82% for CGD and 1.40% for EcoCyc. These data suggest that manual curation of the experimental literature by Ph.D-level scientists is highly accurate. Database URL: http://ecocyc.org/, http://www.candidagenome.org//
Suggestive evidence that the highly metastatic variant ESB of the T‐cell lymphoma eb is derived from spontaneous fusion with a host macrophage (1984)

Two lines of evidence are reported which suggest that the highly metastatic variant ESb of the T-cell lymphoma Eb is derived from spontaneous fusion with a host macrophage. Firstly, ESb cells are shown to express the macrophage differentiation antigen Mac-1 which was not found on Eb cells or on any other tumor cells tested except the macrophage tumor line Pu5. Secondly, the progression from low to high metastatic capacity could be reproduced in vitro following hybridization of thioguanine-resistant Eb cells (EbTGR) with syngeneic bone-marrow-derived macrophages. Two HAT medium-selected hybrid tumor lines (Eb-F1 and Eb-F2) could be established. They were found to express cell surface markers of both parental lines: T lymphoid differentiation antigens from T-lymphoma and macrophage antigens (Mac-1, class II MHC antigens) from the normal cell fusion partner. The antigens were identified on the hybrids and subclones thereof by means of monoclonal antibodies and 3 different detection assays: cytofluorography, complement-dependent cytotoxicity and immunoprecipitation followed by gel electrophoresis. Animals inoculated s.c. with the parental line EbTGR developed local tumors but not metastases and survived for more than 40 days. In contrast, animals inoculated similarly with Eb-F1 or Eb-F2 cells quickly developed metastases in visceral organs and died as early as 10-14 days following inoculation. In many but not all respects, the in vitro-derived T-lymphoma-macrophage hybrids resembled the spontaneous in vivo-derived variant ESb. These findings, together with the presence of Mac-1 antigen on ESb cells, suggest (1) that ESb variant cells may be derived from spontaneous fusion with a host cell, most likely a macrophage and (2) that somatic cell fusion may be an important mechanism of genetic rearrangements leading to metastatic variants. The new highly metastatic tumor lines which were developed under well-defined in vitro conditions, and their subclones, may become very useful tools for studying the contribution of specific genetic traits and of membrane-related structures to various steps of the metastatic process.
A Critical Revision of Host Records of Palearctic Tachinidae (Diptera) until 1937 (2017)

<i>Integrative Systematics: Stuttgart Contributions to Natural History</i>, which continues <i>Stuttgarter Beiträge zur Naturkunde Serie A (Biologie)</i>, is issued by the Stuttgart State Museum of Natural History and publishes articles of general biological interest with a focus on morphological systematics.
Directed synthesis of a segmental chromosomal transposition: an approach to the study of chromosomes lethal to the gametophyte generation of maize. (1991)

Because of the haploid nature of the gametophyte generation of plants, most mutations that are lethal or detrimental to the gametophytes cannot be recovered. Our laboratory is currently developing several techniques to overcome this situation. In this paper, a procedure is described to generate directed segmental chromosomal transpositions. The method involves recovery of recombinants between reciprocal translocation overlaps such that one region of the genome is inserted into a nonhomologous chromosome in a predetermined and directed manner. This duplicated segment then could serve to cover deficiencies or mutations, lethal to the gametophytes, in the region from whence it originated. The manipulation of segmental chromosomal transpositions for analyzing mutants lethal or detrimental to the gametophyte generation is discussed. The procedure to generate transpositions, the translocations between normal A and supernumerary B chromosomes that generate deficiencies in the male gametes, the r-X1 chromosome that generates deficiencies in the female gametes and other techniques available in maize form a system to analyze gametophyte lethal mutations.
A framework for visible-light water splitting (2010)

This review article reports the most significant advances made in H2 production via water-splitting and the challenges that need to be addressed over the coming years to verify the feasibility of H2 production by both inorganic semiconductors and living microorganisms as a competitive process in the hydrogen economy.
ADA Mediation After Sutton, Murphy and Albertson (1999)

Judith Cohen's summary of the Interim ADA Mediation Standards in the last issue of The Journal of Alternative Dispute Resolution in Employment acknowledges the "skyrocketing" number of cases mediated under the Americans With Disabilities Act (ADA). The United States Supreme Court's recent opinions in Sutton v. United Airlines, Inc., Murphy v. United Parcel Service, Inc., and Albertson, Inc. v. Kirkingberg surprised many in the disability community by explicitly excluding an individual from ADA coverage if she mitigates her mental or physical impairment and the impairment as mitigated no longer substantially limits a major life activity. Will the Supreme Court's narrowing interpretation of the definition of "disability" ground the "skyrockets," or, as I suggest below, will the number of mediations in ADA cases continue to soar?
High Temperature Aerospace Materials Prepared by Powder Metallurgy (1982)

This article reviews published data on the mechanical properties of additively manufactured metallic materials. The additive manufacturing techniques utilized to generate samples covered in this review include powder bed fusion (e.g., EBM, SLM, DMLS) and ...Read More
Synthetic manganese–calcium oxides mimic the water-oxidizing complex of photosynthesis functionally and structurally (2011)

In the worldwide search for sustainable energy technologies, water oxidation by abundant low-cost materials is of key importance. In nature, this process is efficiently catalyzed by an intricate manganese–calcium (Mn4Ca) complex bound to the proteins of photosystem II (PSII). Recently synthetic manganese–calcium oxides were found to be active catalysts of water oxidation but at the atomic level their structure has remained elusive. To investigate these amorphous catalysts, extended-range X-ray absorption spectroscopy (XAS) at the K-edges of both manganese and calcium was performed. The XAS results reveal striking similarities between the synthetic material and the natural Mn4Ca complex. The oxidation state of manganese in the active oxides was found to be close to +4, but MnIII ions are present as well at a level of about 20%. Neighboring Mn ions are extensively interconnected by two bridging oxygens, a characteristic feature of layered manganese oxides. However, the oxides do not exhibit long-range order, as opposed to canonical, but catalytically inactive MnIII- or MnIV-oxides. Two different Ca-containing motifs were identified. One of them results in the formation of Mn3CaO4 cubes, as also proposed for the natural paragon in PSII. Other calcium ions likely interconnect oxide-layer fragments. We conclude that these readily synthesized manganese–calcium oxides are the closest structural and functional analogs to the native PSII catalyst found so far. Evolutionary implications are considered. From the differences to inactive manganese oxides, we infer structural features facilitating the catalysis of water oxidation in both the protein-bound Mn4Ca complex of PSII and in the synthetic oxides.
Synthesis of Hollandite‐Type Manganese Dioxide with H+ Form for Lithium Rechargeable Battery (1994)

A hollandite‐type manganese dioxide (HolMO), without foreign metal cations (K+, , Na+ in the tunnel, was prepared directly by reacting with in an acidic solution. The HolMO belonged to a body‐centered tetragonal system (space group l4/m) and could be expressed by the formula . A preliminary electrochemical study suggested that the HolMO is promising as the cathode for a lithium rechargeable battery.
Tapered buffers for gate array and standard cell circuits (2002)

Tapered buffer systems are often used in CMOS circuits to drive large capacitive loads. Well accepted tapered buffer design practices neglect the effects of local interconnect capacitance between the buffer stages. However in many design methodologies, particularly semi-custom ASICs based on gate array or standard cell circuits, buffer stages may not be physically abutted, and therefore significant stage-to-stage local interconnect capacitance may exist. This paper presents a design methodology and analytic relationships for the optimal tapering of cascaded buffers which consider the effects of local interconnect capacitance. The method, constant capacitance-to-current ratio tapering (C/sup 3/RT), is based on maintaining the capacitive load to current drive ratio constant, and therefore the propagation delay of each buffer stage also remains constant. Significant reductions in power dissipation and active area, as well as reduced propagation delay, are exhibited as compared with tapered buffers which neglect local interconnect capacitance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Dual Polarized Microstrip Antenna Array in Polarization-Agile System (2006)

A dual polarization microstrip antenna array with 16 elements is presented in this paper. The array together with the feeding network is analyzed with IE3D software, the S parameter, VSWR, isolation, and radiation pattern of the array are obtained. Numerical results are given, which demonstrate that the dual-polarization array can work well in polarization-agile system.
The magnetochemistry of adsorption of ions from solution (1956)

C. M. French and J. P. Howard, Trans. Faraday Soc., 1956, 52, 996 DOI: 10.1039/TF9565200996