gebhart/patrepeval huggingface dataset:
Verapamil and cyclosporin a sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration (1990)

Vincristine (Vcr) dose dependently inhibited growth of the kidney adenocarcinoma cell line ACHN during 4 days of culture. Verapamil (Ver) at 10 microM and cyclosporin A (CsA) at 1 microgram/ml had no effect on cell growth but significantly potentiated the action of Vcr, despite the absence of the multidrug resistance associated membrane P-glycoprotein (P-gp). Neither Ver nor CsA had any acute or long term effects on cytoplasmic free Ca2+ concentration (Ca2+i), except for a small Ver induced increase after 36 h of incubation. The results indicate that Ver and CsA may have a sensitizing effect on chemotherapeutic drug sensitivity also in absence of P-gp. However, these effects are probably not mediated by changes in Ca2+i.
Happy Eyeballs: Trending Towards Success with Dual-Stack Hosts (2010)

People like their computers to work quickly. During the transition to
new technology, both old and new technologies have to peacefully co-
exist. However, if users experience connection delays attributed to
the new technology the new technology will be shunned. HTTP (The
Web) is one of the most visible and time-critical applications that
is used by nearly every Internet user. It is critical that new
technologies which improve HTTP not impair or delay the display of
HTTP content. It is also important that users retain the ability to
share URIs amongst friends and colleagues, even if the other users
have not upgraded to the new technology. This draft makes several
recommendations to ensure user satisfaction and a smooth transition
from IPv4 to IPv6 with dual-stack hosts. The audience for this draft
is application developers and content providers. This draft is
discussed on the v6oops mailing list,
https://www.ietf.org/mailman/listinfo/v6ops.
Effect of pH, Fluorination, and Number of Layers on the Inhibition of Electrochemical Reactions by Grafted, Hyperbranched Poly(acrylic acid) Films (1997)

Abstract We report the electrode‐passivation properties of both fluorinated and unmodified hyperbranched poly(acrylic acid) (PAA) films as a function of pH and the number of PAA layers. Both cyclic voltammetry and ac‐impedance spectroscopy show that the extent of blocking increases with the number of layers, regardless of the solution pH. However, passivation resulting from unfluorinated PAA films decreases with increasing pH, while passivation due to fluorinated films increases with increasing pH. Three‐layer fluorinated films can increase the charge transfer resistance of the electrode by up to a factor of 6 × 10 4 . Although Randles' equivalent circuit can be used to model the electrochemistry of electrodes covered with unfluorinated PAA, fluorinated PAA‐coated electrodes often require additional circuit elements due to the high resistance of these hydrophobic films.
Regulation of nitric oxide production in health and disease (2009)

Both lack and excess of nitric oxide production in diseases can have various important implications in which dietary factors can play a modulating role. Future research is needed to expand our understanding of the regulation and adequate measurement of nitric oxide production at the organ level and by the different nitric oxide synthase isoforms, also in relation to clinical nutrition.
Age-Related Prognostic Impact of Different Types of <i>DNMT3A</i> Mutations in Adults With Primary Cytogenetically Normal Acute Myeloid Leukemia (2012)

DNMT3A mutations are frequent in CN-AML, and their clinical significance seems to be age dependent. DNMT3A-R882 mutations are associated with adverse prognosis in older patients, and non-R882-DNMT3A mutations are associated with adverse prognosis in younger patients. Low accuracy of gene- and microRNA-expression signatures in predicting DNMT3A mutation status suggested that the role of these mutations in AML remains to be elucidated.
Theory and practice of flash memory mobile forensics (2009)

This paper is an introduction to flash memory forensics with a special focus on completeness of evidence acquired from mobile phones. Moving through academic papers and industrial documents will be introduced the particular nature of non-volatile memories present in nowadays mobile phones; how they really work and which challenges they pose to forensic investigators. Then will be presented an advanced test in which some brand new flash memories have been used to hide data in man-made bad blocks: the aim is to verify if forensic software tools are able to acquire data from such blocks, and to evaluate the possibility to hide data at analysts’ eyes.
Art-Centered Approach to Diversity Education in Teaching and Learning. (2002)

We found that various ubiquinone analogs regulate PTP in different ways depending on the cell studied. We took advantage of this unique property to develop a PTP opening-targeted strategy that leads to cell death specifically in cells where the ubiquinone analog used induces PTP opening, while sparing the cells in which it does not induce PTP opening.
A kinetic study of the disproportionation of potassium benzoate (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA kinetic study of the disproportionation of potassium benzoateV. V. S. Revankar and L. K. DoraiswamyCite this: Ind. Eng. Chem. Res. 1987, 26, 8, 1691–1695Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/ie00068a034https://doi.org/10.1021/ie00068a034research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation (2021)

AI-based analysis of 12-lead ECGs has similar predictive usefulness to a clinical risk factor model for incident AF and the approaches are complementary. ECG-AI may enable efficient quantification of future AF risk.
High power and widely tunable Si hybrid external-cavity laser for power efficient Si photonics WDM links (2014)

A highly efficient silicon (Si) hybrid external cavity laser with a wavelength tunable ring reflector is fabricated on a complementary metal-oxide semiconductor (CMOS)-compatible Si-on-insulator (SOI) platform and experimental results with high output power are demonstrated. A III-V semiconductor gain chip is edge-coupled into a SOI cavity chip through a SiN(x) spot size converter and Si grating couplers are incorporated to enable wafer-scale characterization. The laser output power reaches 20 mW and the highest wall-plug efficiency of 7.8% is measured at 17.3 mW in un-cooled condition. The laser wavelength tuning ranges are 8 nm for the single ring reflector cavity and 35 nm for the vernier ring reflector cavity, respectively. The Si hybrid laser is a promising light source for energy-efficient Si CMOS photonic links.
Wide-sense nonblocking Clos networks under packing strategy (2002)

In this paper, we study wide-sense nonblocking conditions under packing strategy for the three-stage Clos network, or v(m, n, r) network. Wide-sense nonblocking networks are generally believed to have lower network cost than strictly nonblocking networks. However, the analysis for the wide-sense nonblocking conditions is usually more difficult. Moore proved that a v(m, n, 2) network is nonblocking under packing strategy if the number of middle stage switches m/spl ges/[/sup 3///sub 2/n]. This result has been widely cited in the literature, and is even considered as the wide-sense nonblocking condition under packing strategy for the general v(m, n, r) networks in some papers. In fact, it is still not known that whether the condition m/spl ges/[/sup 3///sub 2/n] holds for v(m, n, r) networks when r/spl ges/3. In this paper, we introduce a systematic approach to the analysis of wide-sense nonblocking conditions under packing strategy for general v(m, n, r) networks with any r values. We first translate the problem of finding the necessary and sufficient nonblocking conditions for v(m, n, r) networks to a set of linear programming problems. We then solve this special type of linear programming problems and obtain an elegant dosed form optimum solution. We prove that the necessary and sufficient condition for a v(m, n, r) network to be nonblocking under packing strategy is m/spl ges/[(2-1/F/sub 2r-1/)n] where F/sub 2r-1/ is the Fibonaaci number. We believe that the systematic approach developed in this paper can be used for analyzing other wide-sense nonblocking control strategies as well.
The Special Challenges of Offering High Quality Experience for VR Video (2016)

The recent invasion of Virtual Reality (VR) headsets on the consumer market leaves little doubt that the media & entertainment industry sees VR as a promising experience for users. Nevertheless, there is still very little VR video content available and the gaming industry remains the foremost user of VR headsets. VR video content available today is often produced and delivered through traditional video workflows and while it offers an interesting user experience, video quality is significantly lower than with traditional video. The lack of interoperable formats and adapted delivery solutions for VR video content is for no doubt a first obstacle for the media industry. Fortunately, Standards Development Organizations and Industry Forums have now embraced the VR topic. The present paper aims at presenting these new technical challenges for offering high quality VR video content. More specifically, focus will be put on format, compression and delivery of VR video content.
Skorpion Zinc : optimization and innovation (2007)

The Skorpion process comprises three processing steps-atmospheric leaching in sulfuric acid, zinc solvent extraction and electrowinning to produce special high grade zinc. The major mode of impurity transfer was attributed to crud runs in the solvent extraction circuit. Crud may be descriptionbed as a heterogeneous, partly inorganic, partly organic mass of material which accumulates predominantly at the interface between organic and aqueous solutions. The paper descriptionbes the root causes of the crud formation in the solvent extraction circuit and optimization strategies which are being followed to prevent impurity excursions in electrowinning. Keywords: zinc oxide, solvent extraction, crud formation, colloidal silica.
Highly reliable A/D converter using analog voting (2008)

Analog and digital circuits are both prone to failure due to transient upsets, variations, etc. Redundancy techniques, such as N-tuple Modular Redundancy, has been widely used to correct faulty behavior of components and achieve high reliability for digital circuits, whereas, not much has been done on the analog side. In this paper, we propose a redundancy based fault-tolerant methodology to design a highly reliable analog to digital converters (ADC). Our methodology employs redundant analog blocks and chooses the best result using an innovative analog voter. Experimental results are reported to verify the concepts, measure the systempsilas reliability and tradeoff reliability versus cost and power.
A harmonic bandwidth extension based on Gaussian mixture model (2010)

For conventional bandwidth extension, the spectral patching methods, such as spectral folding, spectral translation and non-linear processing, are employed to reconstruct high frequency signal, yet it leads to the spectral shifting between reconstructed and original signal, and does not retain the original harmonic relations. In this paper, a blind harmonic bandwidth extension method from wideband to super-wideband was proposed by estimating the energy of high frequency spectral envelope with Gaussian mixture model (GMM). Both the objective and subjective test results show that proposed algorithm performs better than conventional blind bandwidth extension algorithms.
Bipolar redox behaviour, field-effect mobility and transistor switching of the low-molecular azo glass AZOPD (2010)

We present electrochemical and spectroelectrochemical data for the bipolar azo compound N,N'-diphenyl-N,N'-bis[4-(phenylazo)phenyl]-4,4'diaminobiphenyl (AZOPD) demonstrating reversible bipolar redox behaviour with a bandgap of 2.1 eV. The reduced species formed upon two-electron transfer can be described as bis(radical anion) as was confirmed by comparison with a reference compound with only one azo chromophore. Hole and electron transport behaviour in amorphous films was demonstrated by the fabrication of organic field-effect transistors using gold and magnesium contacts, respectively. The transistors are sensitive to light due to E-Z photoisomerization.
A Protocol to 2-Aminobenzimidazoles via Copper-Catalyzed Cascade Addition and Cyclization of <i>o</i>-Haloanilines and Carbodiimides (2011)

An efficient strategy for the synthesis of a variety of 2-animobenzimidazole derivatives has been developed. The reaction proceeded from o-haloanilines and carbodiimides via copper(I)-catalyzed domino reaction in the presence of tert-butoxide to afford the corresponding 2-animobenzimidazole derivatives in good to excellent yields. o-Haloanilines could be o-iodoaniline, o-bromoaniline, and o-chloroaniline derivatives. Carbodiimides could be symmetrical and unsymmetrical substrates with aryl or alkyl substituents. The reaction exhibited a good regioselectivity when unsymmetrical carbodiimides were employed.
TLR-Induced Inflammation in Cystic Fibrosis and Non-Cystic Fibrosis Airway Epithelial Cells (2005)

Cystic fibrosis (CF) is a genetic disease characterized by severe neutrophil-dominated airway inflammation. An important cause of inflammation in CF is Pseudomonas aeruginosa infection. We have evaluated the importance of a number of P. aeruginosa components, namely lipopeptides, LPS, and unmethylated CpG DNA, as proinflammatory stimuli in CF by characterizing the expression and functional activity of their cognate receptors, TLR2/6 or TLR2/1, TLR4, and TLR9, respectively, in a human tracheal epithelial line, CFTE29o(-), which is homozygous for the DeltaF508 CF transmembrane conductance regulator mutation. We also characterized TLR expression and function in a non-CF airway epithelial cell line 16HBE14o(-). Using RT-PCR, we demonstrated TLR mRNA expression. TLR cell surface expression was assessed by fluorescence microscopy. Lipopeptides, LPS, and unmethylated CpG DNA induced IL-8 and IL-6 protein production in a time- and dose-dependent manner. The CF and non-CF cell lines were largely similar in their TLR expression and relative TLR responses. ICAM-1 expression was also up-regulated in CFTE29o(-) cells following stimulation with each agonist. CF bronchoalveolar lavage fluid, which contains LPS, bacterial DNA, and neutrophil elastase (a neutrophil-derived protease that can activate TLR4), up-regulated an NF-kappaB-linked reporter gene and increased IL-8 protein production in CFTE29o(-) cells. This effect was abrogated by expression of dominant-negative versions of MyD88 or Mal, key signal transducers for TLRs, thereby implicating them as potential anti-inflammatory agents for CF.
Improved Dynamic ID-Based Remote User Authentication Scheme Using Smart cards (2008)

In 2004, Das presented a dynamic ID-based remote user authentication scheme using smart cards. Then in 2005, Liao showed that Das et al.'s scheme has some attacks and proposed a slight modification to their scheme to improve the weaknesses of it. This paper, however, will demonstrate that Liao et al.'s scheme has also some security flaws. Therefore, we propose an improved scheme to conquer their weaknesses. The improved scheme can enhance the security of Liao et al.'s scheme and is also efficient.
Overview of IEEE 1857 video coding standard (2013)

IEEE 1857 is a multi-part standard for multimedia data compression and transmission in a highly efficient way under constraints, which include limited complexity and bandwidth. IEEE 1857 video part is organized in an application-oriented way that suitable tools are chosen to get a high compression ratio. This paper will give an overview of its six profiles (Main, Broadcasting, Enhanced, Portable, Surveillance Baseline, and Surveillance) which are designed respectively for normal video, high-definition video broadcasting, digital cinema, video communication among portable devices and surveillance video. In the paper, the background of application requirement and the key coding tools of IEEE 1857 video coding standards are introduced, and the performance comparison between IEEE 1857 and the state-of-the art coding standards are provided.
Moisture effects on Protein—Excipient Interactions in Spray-dried Powders. Nature of Destabilizing effects of Sucrose (1999)

The preparation of stable solid protein formulations presents significant challenges. Ultimately, the interactions between incorporated excipients and the pharmaceutical protein determine the formulation stability. In this study, moisture was utilized to probe the interactions between a model protein, trypsinogen, and sucrose in the solid state, following spray drying. Through investigation of the physical properties of the spray-dried formulations, we attempted to elucidate the mechanisms underlying the previously observed stabilizing and destabilizing effects of the carbohydrate during spray drying. Both dynamic and equilibrium moisture uptake studies indicated the presence of an optimal protein-sugar hydrogen bonding network. At low sucrose contents, a preferential protein-sucrose hydrogen bonding interaction was dominant, resulting in protein stabilization. However, at high carbohydrate concentrations, preferential sugar-sugar interactions prevailed, resulting in a phase separation within the formulation matrix. The preferential incorporation of the sucrose molecules in a sugar-rich phase reduced the actual amount of the carbohydrate available to interact with the protein and thereby decreased the number of effective protein-sucrose contacts. As a consequence, the protein could not be effectively protected during spray drying. We hypothesize that the observed phase separation at this sucrose concentration regime originates from its exclusion from the protein in solution before spray drying, further accompanied by preferential clustering of the sucrose molecules.
A distributed approach to GIS systems and location-based service for Internet-enabled handheld mobile devices (2008)

Geographical information systems for PCs and mobile devices are rapidly gaining popularity. This paper presents a new server-based GIS architecture which is unique in that it is a totally WAP browser based application with user interface in HTML or WML and J2ME and relying entirely on Internet in mobile devices via wireless LANs or GPRS for accessibility. Wireless Internet-based distributed GIS (WIEOS) is a distributed two tier location information system This distributed GIS architecture is based on a system of Java Servlets deployed in a system with fixed global IP address that regulates the flow of information to clients requesting service from it. The data can be textual or in the form of a map showing the relevant location information A J2ME application, running at the client's handset, is capable of tracking GPS signals, downloading maps and indicating the user's exact position on the downloaded map, thus tracing out his movements. Also, it is possible to simulate a particular client's movements using a JAVA Swing application deployed in the server.
Understanding, evaluating, and supporting self-regulated learning using learning analytics (2015)

Self-regulated learning is an ongoing process rather than a single snapshot in time. Naturally, the field of learning analytics, focusing on interactions and learning trajectories, offers exciting opportunities for analyzing and supporting self-regulated learning. This special section highlights the current state of research in the intersect of self-regulated learning and learning analytics, bridging communities, disciplines, and schools of thoughts. In this editorial, we introduce the papers and identify themes and challenges in understanding and support self-regulated learning in interactive learning environments.
RFID for road tolling, road-use pricing and vehicle access control (1999)

This paper provides an insight into the use of in-vehicle tags and transponders to facilitate roadside to vehicle data-communications for electronic tolling and road-use pricing systems. In particular the devices which adhere to the new European standard on dedicated road to vehicle communications (DSRC) are described and discussed.
Mechanisms of Action of New Immunosuppressive Drugs (1995)

More immunosuppressive drugs than ever have recently graduated from the laboratory to extensive clinical trials of their safety and efficacy in transplant patients. None of these drugs is perfect, but they control different forms of rejection in stringent animal models more effectively than other immunosuppressants, and these novel molecules suppress the immune system far more specifically than steroids and regimens that cause lymphopenia. Cyclosporin A and FK506 are the only drugs that selectively inhibit T-cell proliferation by blocking cytokine synthesis. The primary action of rapamycin appears to be inhibition of the actions of cytokines and growth factors on T, B, and some nonimmune cells. T and B cells are more sensitive than nonimmune cells to the depletion of purines and pyrimidines caused by mizoribine, mycophenolate mofetil, brequinar sodium, and leflunomide. Nucleotide depletion causes interruption of DNA synthesis and glycosylation of adhesion molecules in immune cells. Further differentiation of T and B cells after proliferation into fully functional immune cells is inhibited by unknown mechanisms of brequinar and deoxyspergualin. On the basis of preclinical studies, these drugs may effectively suppress clinical rejection that is acute (all), chronic (rapamycin, leflunomide, mycophenolate mofetil), or antibody mediated (brequinar, deoxyspergualin, mycophenolate mofetil, rapamycin, leflunomide). Some drugs (FK506, deoxyspergualin, mycophenolate mofetil, rapamycin, leflunomide) may reverse acute rejection refractory to conventional immunosuppression. Not only do these new drugs block different biochemical steps that normally lead to fully functional T and B cells after stimulation by alloantigen, but their toxicity profiles also differ. Results from preclinical studies predict that use of selected combinations of these drugs will be more effective, less nephrotoxic, less myelotoxic, and less broadly immunosuppressive than current regimens based on cyclosporine, T-cell depletion, steroids, and azathioprine.