gebhart/patrepeval huggingface dataset:
Tolerability and efficacy of N-chlorotaurine in comparison with chloramine T for the treatment of chronic leg ulcers with a purulent coating: a randomized phase II study (2003)

Both active chlorine compounds were helpful in reducing purulent coatings. Because of its lower toxicity and better tolerability, NCT is of advantage in the treatment of leg ulcers.
Design Considerations in Drill Cuttings Re-Injection Through Downhole Fracturing (2001)

Abstract Upstream environmental policies require the use of best available and economically sound technology to continually reduce discharge of mud and cuttings waste resulting from drilling operations. Downhole disposal of mud and cuttings waste through hydraulic fracturing provides a zero discharge solution and eliminates future cleanup liabilities when the loop is closed. This downhole disposal technology has shown success in both onshore and offshore drilling operations and is becoming a routine disposal option of complying with environmental legislation concerning discharges of drilling waste. It also offers favorable economics. Careful job planning, proper operation design, strict quality assurance and systematic monitoring and analysis are the key to the success of waste disposal operations. Important drill cuttings re-injection engineering design and assurance process are presented in this paper. These include job planning, data required for subsurface geology or formation description and logging analysis, criteria for disposal well and injection zone selection and requirement for slurry rheology quality control. Also presented in this paper are design guidelines for injection strategy selection and injection parameters such as injection rate, batch size, shut-in time required for fracture to close on cuttings, injection equipment requirements, and disposal capacity estimates. Issues related to risk management and commingling of drilling waste injection and produced water injection in the same well are also briefly touched.
A comparison between spiking and signature deconvolution (1984)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1984A comparison between spiking and signature deconvolutionAuthors: Bob Godfrey'Jim MontalbettiBob Godfrey'Digital Exploration Ltd., England and Jim MontalbettiPulsonic Geophysical Ltd., Canadahttps://doi.org/10.1190/1.1894160 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1894160FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1984ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1984 Pages: 856 publication data© 1984 Copyright © 1984 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 24 Mar 2005 CITATION INFORMATION Bob Godfrey' and Jim Montalbetti, (1984), "A comparison between spiking and signature deconvolution," SEG Technical Program Expanded Abstracts : 608-611. https://doi.org/10.1190/1.1894160 Plain-Language Summary PDF DownloadLoading ...
Synthesis of a Fluorophore with Improved Optical Brightness (2013)

The synthesis and characterization of a novel fluorophore(<b>1</b>), with potential application as an optical brightener are reported. This compound was prepared by reacting 4,4-diaminostilbene-2,2-disulfonic acid with cyanuric chloride in the presence of Na<sub>2</sub>CO<sub>3</sub> followed by the addition of trityl aniline. Solution and solid state fluorescence demonstrated a strong blue/purple emission centered at 450 nm. <sup>1</sup>H-NMR spectroscopy, mass spectrometry analysis, elemental analysis, and DOSY-NMR were used for the characterization of the fluorophore.
Synthesis of a novel cytokine and its gene (LD78) expressions in hematopoietic fresh tumor cells and cell lines. (1989)

The gene coding for the protein LD78 was isolated from stimulated human tonsillar lymphocytes by differential hybridization. The gene product consisted of 92 amino acids with characteristics of cytokines. LD78 gene transcripts were detected in eight of eight fresh samples of cells from patients with acute nonlymphocytic leukemia (ANLL) by Northern blot analysis. ANLL cells with monocytic features gave the strongest bands. RNA transcripts were found in two of three samples of cells from patients with adult T cell leukemia (ATL), eight of nine samples from patients with acute lymphocytic leukemia (ALL) of B cell lineage, and one of the three samples from patients with T cell ALL. KG-1, HL-60, HUT 102, MT-2, and MJ cell lines expressed the LD78 gene constitutively. The LD78 protein was detected in culture supernatants and cell lysates of HUT 102, MT-2, MJ, and fresh ATL cells by Western blot analysis. This protein was not found in culture supernatants or cell lysates of monocytic leukemia cells and HL-60 cells, although LD78 transcripts were found in those cells. The discrepancy between gene and protein expression might be explained by the stability of the mRNA. Thus, the protein may be involved in the neoplastic transformation of hematopoietic cells.
Design of a Piezoelectric Sensor-Based Controller for Mitigation of Torque Ripple in a Brushless DC Machine (2002)

<div class="htmlview paragraph">Brushless dc machines with non-sinusoidal back-emf are often characterized by significant torque ripple that occurs as a result of the interaction of back-emf and stator current harmonics, as well as cogging torque. In this paper, a method of mitigating the torque ripple is described that utilizes closed-loop feedback control. Specifically, the torque ripple produced by a machine is measured using a piezoelectric sensor. The sensor is constructed from polyvinylidene fluoride (PVDF) film, which produces a voltage in response to subtle strains in the motor housing. The sensed torque ripple provides a feedback that is used to determine stator current harmonics utilizing a controller that is based upon cost function minimization. Simulation and experimental results are used to demonstrate the effectiveness of the control technique.</div>
Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant (2011)

This report describes the behavioral and electrophysiological analysis of regulatable transgenic mice expressing mutant repeat domains of human Tau (Tau(RD)). Mice were generated to express Tau(RD) in two forms, differing in their propensity for β-structure and thus in their tendency for aggregation ("pro-aggregant" or "anti-aggregant") (Mocanu et al., 2008). Only pro-aggregant mice show pronounced changes typical for Tau pathology in Alzheimer's disease (aggregation, missorting, hyperphosphorylation, synaptic and neuronal loss), indicating that the β-propensity and hence the ability to aggregate is a key factor in the disease. We now tested the mice with regard to neuromotor parameters, behavior, learning and memory, and synaptic plasticity and correlated this with histological and biochemical parameters in different stages of switching Tau(RD) on or off. The mice are normal in neuromotor tests. However, pro-aggregant Tau(RD) mice are strongly impaired in memory and show pronounced loss of long-term potentiation (LTP), suggesting that Tau aggregation specifically perturbs these brain functions. Remarkably, when the expression of human pro-aggregant Tau(RD) is switched on for ∼ 10 months and off for ∼ 4 months, memory and LTP recover, whereas aggregates decrease moderately and change their composition from mixed human plus mouse Tau to mouse Tau only. Neuronal loss persists, but synapses are partially rescued. This argues that continuous presence of amyloidogenic pro-aggregant Tau(RD) constitutes the main toxic insult for memory and LTP, rather than the aggregates as such.
In situ assembly of linked geometrically coupled microdevices (2008)

Complex systems require their distinct components to function in a dynamic, integrated, and cooperative fashion. To accomplish this in current microfluidic networks, individual valves are often switched and pumps separately powered by using macroscopic methods such as applied external pressure. Direct manipulation and control at the single-device level, however, limits scalability, restricts portability, and hinders the development of massively parallel architectures that would take best advantage of microscale systems. In this article, we demonstrate that local geometry combined with a simple global field can not only reversibly drive component assembly but also power distinct devices in a parallel, locally uncoupled, and integrated fashion. By employing this single approach, we assemble and demonstrate the operation of check valves, mixers, and pistons within specially designed microfluidic environments. In addition, we show that by linking these individual components together, more complex devices such as pumps can be both fabricated and powered in situ.
HMM-Based Deception Recognition from Visual Cues (2005)

Behavioral indicators of deception and behavioral state are extremely difficult for humans to analyze. This research effort attempts to leverage automated systems to augment humans in detecting deception by analyzing nonverbal behavior on video. By tracking faces and hands of an individual, it is anticipated that objective behavioral indicators of deception can be isolated, extracted and synthesized to create a more accurate means for detecting human deception. Blob analysis, a method for analyzing the movement of the head and hands based on the identification of skin color is presented. A proof-of-concept study is presented that uses Blob analysis to extract visual cues and events, throughout the examined videos. The integration of these cues is done using a hierarchical hidden Markov model to explore behavioral state identification in the detection of deception, mainly involving the detection of agitated and over-controlled behaviors
Fast identification of optimal fascicle configurations from standard clinical diffusion MRI using Akaike information criterion (2014)

Analytic multi-compartment models have gained a tremendous popularity in the recent literature for studying the brain white matter microstructure from diffusion MRI. This class of models require the number of compartments to be known in advance. In the white matter however, several non-collinear bundles of axons, termed fascicles, often coexist in a same voxel. Determining the optimal fascicle configuration is a model selection problem. In this paper, we aim at proposing a novel approach to identify such a configuration from clinical diffusion MRI where only few diffusion images can be acquired and time is of the essence. Starting from a set of fitted models with increasing number of fascicles, we use Akaike information criterion to estimate the probability of each candidate model to be the best Kullback-Leibler model. These probabilities are then used to average the different candidate models and output an MCM with optimal fascicle configuration. This strategy is fast and can be adapted to any multi-compartment model. We illustrate its implementation with the ball-and-stick model and show that we obtain better results on single-shell low angular resolution diffusion MRI, compared to the state-of-the-art automatic relevance detection method, in a shorter processing time.
An Automated Pipeline for High-Throughput Label-Free Quantitative Proteomics (2013)

We present a computational pipeline for the quantification of peptides and proteins in label-free LC–MS/MS data sets. The pipeline is composed of tools from the OpenMS software framework and is applicable to the processing of large experiments (50+ samples). We describe several enhancements that we have introduced to OpenMS to realize the implementation of this pipeline. They include new algorithms for centroiding of raw data, for feature detection, for the alignment of multiple related measurements, and a new tool for the calculation of peptide and protein abundances. Where possible, we compare the performance of the new algorithms to that of their established counterparts in OpenMS. We validate the pipeline on the basis of two small data sets that provide ground truths for the quantification. There, we also compare our results to those of MaxQuant and Progenesis LC–MS, two popular alternatives for the analysis of label-free data. We then show how our software can be applied to a large heterogeneous data set of 58 LC–MS/MS runs.
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone (2002)

Midzone microtubules of mammalian cells play an essential role in the induction of cell cleavage, serving as a platform for a number of proteins that play a part in cytokinesis. We demonstrate that PRC1, a mitotic spindle-associated Cdk substrate that is essential to cell cleavage, is a microtubule binding and bundling protein both in vivo and in vitro. Overexpression of PRC1 extensively bundles interphase microtubules, but does not affect early mitotic spindle organization. PRC1 contains two Cdk phosphorylation motifs, and phosphorylation is possibly important to mitotic suppression of bundling, as a Cdk phosphorylation-null mutant causes extensive bundling of the prometaphase spindle. Complete suppression of PRC1 by siRNA causes failure of microtubule interdigitation between half spindles and the absence of a spindle midzone. Truncation mutants demonstrate that the NH2-terminal region of PRC1, rich in alpha-helical sequence, is important for localization to the cleavage furrow and to the center of the midbody, whereas the central region, with the highest sequence homology between species, is required for microtubule binding and bundling activity. We conclude that PRC1 is a microtubule-associated protein required to maintain the spindle midzone, and that distinct functions are associated with modular elements of the primary sequence.
Femtosecond Beam Combination Using Diffractive Optic Pairs (2017)

A new, scalable method of ultrashort pulse, coherent beam combination is modeled numerically and demonstrated experimentally. 110fs, 1040nm pulses in a 1×4 array are combined using two diffractive optics, preserving pulse duration and spectral width.
Radio imaging of geologic structure in coal seams (1990)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1990Radio imaging of geologic structure in coal seamsAuthors: Larry G. StolarczykLarry G. StolarczykStolar Inc.https://doi.org/10.1190/1.1890311 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1890311FiguresReferencesRelatedDetailsCited byOverview on the application of geophysics in coal miningInternational Journal of Coal Geology, Vol. 114 SEG Technical Program Expanded Abstracts 1990ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1990 Pages: 1779 publication data© 1990 Copyright © 1990 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Larry G. Stolarczyk, (1990), "Radio imaging of geologic structure in coal seams," SEG Technical Program Expanded Abstracts : 721-725. https://doi.org/10.1190/1.1890311 Plain-Language Summary PDF DownloadLoading ...
Noise Impairment In Coded Video Signals And Possible Reduction Philosophy (1984)

The author analyses the fundamental aspects of noise degradation due to the coding/decoding process in a colour video chain. The effects of noise spectra, filter bandwidths, and gamma correction may be seen in terms of their relative significance.
A facile and highly sensitive probe for Hg(ii) based on metal-induced aggregation of ZnSe/ZnS quantum dots (2012)

Sensitive and selective detection strategies for toxic heavy metal ions, which are rapid, cheap and applicable to environmental and biological fields, are of significant importance. As a result of specific interaction between thiol(s) used as ligands and heavy metal ions, the photoluminescence intensity of quantum dots (QDs) in PBS buffer solution was quenched and the aggregation of QDs was formed at the same time. Herein, we present water-soluble, low toxic QDs, ZnSe/ZnS, which were applied for ultrasensitive Hg(2+) ion detection with a low detection limit (2.5 nM). In addition, a model has been proposed to explain the aggregation of QDs in the presence of heavy metal ions such as Hg(2+) ions.
Multistage joint detection with decision feedback for CDMA mobile radio applications (2002)

This paper focuses on the performance of a multistage joint detection (MJD) scheme for CDMA mobile radio applications, which combines the relatively low complexity of a linear estimation with low bit error rates. Minimum-mean-square-error linear block estimation (MMSE-LBE) is applied in combination with decision feedback. Due to relatively low computational complexity of the LBE algorithm a large number of transmitted symbols can be reliably and cost effectively estimated simultaneously in a first detection stage. Since in the second stage the number of 'unknown' symbols is significantly reduced, the performance of MMSE-LBE is noticeable increased. Monte-Carlo simulations, which include mobile radio channel models, show that significant SNR gains of more than 25 dB can be achieved due to a second detection stage.
Fine structural study of the red seaweed Gymnogongrus torulosus (Phyllophoraceae, Rhodophyta) (2003)

The present study analyzed several characters of the red seaweed Gymnogongrus torulosus, such as cellular structure of the thallus, cuticle, pit plug and cell wall ultrastructure, and morphology of some organelles like plastids, Golgi bodies and mitochondria. Also, anomalous chloroplasts with thylakoid disorganization were found in medullary cells. The significance of this thylakoid disposition is still unclear. This is one of the first studies focused on the fine structure of a red alga recorded in Argentina.
Technosphere <sup>®</sup> Insulin Technology (2007)

The ideal prandial insulin would possess characteristics of the insulin response profile seen in healthy individuals without diabetes. Approximating the early-phase insulin response that is lost in diabetes is challenging for injected insulins, especially achieving rapid insulin absorption and a favorable duration of metabolic effect. Technosphere (MannKind Corp., Valencia, CA) inhalation powder is a novel delivery platform that enables large peptides to be delivered via the pulmonary route. Technosphere Insulin (TI), a formulation of regular human insulin, has been specifically designed to facilitate efficient transport via the inhaled route. TI is rapidly absorbed (time to maximum effect of approximately 15 min) and has a rapid onset of action. The metabolic effect of TI peaks approximately 1 h after administration, substantially earlier than what has been reported for other insulins. The majority of the glucose-lowering activity of TI is delivered in the first 3 h. In preliminary studies, TI was well tolerated. Phase 3 studies are under way to evaluate the long-term efficacy and safety of TI in patients with type 1 and type 2 diabetes.
Studies on the Possible Central and Peripheral Effects in Man of a Cholinesterase Inhibitor (Pyridostigmine) (1985)

The effect of a reversible cholinesterase inhibitor (pyridostigmine: 30 mg, 8-hourly for 3 days) on psychomotor performance and visual function and on the electrical activity of the brain was studied in healthy man. It was not possible to detect any change during the six individual experimental sessions over the 3 days, but with pooling of the data there was a drug effect. The threshold for detection of a flickering light was increased and less responses were missed on a dynamic visual-acuity task. Visuo-motor coordination was impaired. The observations were consistent with the known activity of the drug and suggest an increase in central arousal and minimal alteration in motor coordination.
<title>Synthesis and characterization of cyanine dyes as contrast agents for near-infrared imaging</title> (1996)

The diagnostic potential of the near-infrared imaging method can be enhanced using fluorescent dyes as contrast agents. In the pool of fluorescent dyes (e.g. tetrapyrroles, polymethines) the cyanine dyes are the most promising ones because of their high molar absorption between 700 and 1000 nm, minimal phototoxicity and convenient synthetic availability. The potential of indocyanine green (ICG) as a contrast agent for optical mammography has been investigated. The major drawbacks of this compound are a rapid liver uptake after intravenous injection, a low fluorescence quantum yield and low stability in aqueous solutions. Our purpose was to generate indotricarbocyanine derivatives structurally related to ICG with improved photophysical and pharmacological properties. Several dyes more hydrophilic than ICG and covering a wide polarity range were synthesized. The dyes were characterized photophysically (absorption and fluorescence spectra, molar absorptivities and fluorescence quantum yields in different physiological media) and physicochemically (partition coefficients, plasma protein binding).
Expansion of Metallic Cylinders under Explosive Loading (1992)

The behaviour of expanding metallic cylinders under explosive loading was studied. Using ultra high speed photography, the expansion characteristics of aluminium and copper metallic cylinders have been evaluated with different c/m ratio, and by changing the nature of high explosive. The results obtained are comparable to those predicted by the Gurney's energy and momentum balance equations. A cylinder test has been established for comparative to the metal by octol, TNT, PEK-1, baratol and composition B are calculated. The results are in close agreement with those calculated by Kury et al.
A pencil beam algorithm for proton dose calculations (1996)

The sharp lateral penumbra and the rapid fall-off of dose at the end of range of a proton beam are among the major advantages of proton radiation therapy. These beam characteristics depend on the position and characteristics of upstream beam-modifying devices such as apertures and compensating boluses. The extent of separation, if any, between these beam-modifying devices and the patient is particularly critical in this respect. We have developed a pencil beam algorithm for proton dose calculations which takes accurate account of the effects of materials upstream of the patient and of the air gap between them and the patient. The model includes a new approach to picking the locations of the pencil beams so as to more accurately model the penumbra and to more effectively account for the multiple-scattering effects of the media around the point of interest. We also present a faster broad-beam version of the algorithm which gives a reasonably accurate penumbra. Predictions of the algorithm and results from experiments performed in a large-field proton beam are presented. In general the algorithm agrees well with the measurements.
Biodegradation of mixtures of chlorophenoxyalkanoic acid herbicides by Alcaligenes denitrificans (2000)

An Alcaligenes denitrificans strain able to degrade ( R ) -2 -( 2 -methyl -4 -chlorophenoxy ) propionic acid [ ( R ) -MCPP, mecoprop ] was assessed for its ability to utilise a range of chlorophenoxyalkanoic acid herbicides in single, binary, tertiary and quaternary combinations in batch culture. Degradation rates were rapid with single growth substrates; complete degradation occurred within 29 h for 2,4 -dichlorophenoxyacetic acid ( 2,4 -D ) , 43 h for 4 -chloro -2methylphenoxyacetic acid ( MCPA ) and 50 h for ( R ) -MCPP, respectively. After 20 h, the degradation of ( RS ) -2-( 2,4 -dichlorophenoxy ) propionic acid [ ( RS ) -2,4 -DP ] had ceased, with only the ( R ) -enantiomer being degraded. In binary combination, 2,4 -D and MCPP degraded within 55 h. Degradation rates decreased when herbicides were added in tertiary and quaternary combinations. Thus, at the whole cell level, catalysis of closely related herbicides is likely to be facilitated by diverse enzymatic activity in A. denitrificans.