gebhart/patrepeval huggingface dataset:
3D long offset non‐hyperbolic velocity analysis (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19973D long offset non‐hyperbolic velocity analysisAuthors: David H. CarlsonDavid H. CarlsonPGS Tensorhttps://doi.org/10.1190/1.1885754 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885754FiguresReferencesRelatedDetailsCited byAnisotropic velocity analysis and moveout: a practical approachLee Lu, Jeffery Chen, and Wei‐Dong Chen6 January 2005 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION David H. Carlson, (1997), "3D long offset non‐hyperbolic velocity analysis," SEG Technical Program Expanded Abstracts : 1693-1694. https://doi.org/10.1190/1.1885754 Plain-Language Summary PDF DownloadLoading ...
REVIEWS OF BOOKS (1959)

Journal Article REVIEWS OF BOOKS Get access Fress Fief to Indenture: the Transition from Feudal to Non-feudal Contract in Western Europe. By BRYCE D. LYON. Harvard Historical Studies,lxviii.(Cambridge, Mass. : Harvard University Press; London: o. u. P., 1957.) EDWARD MILLER EDWARD MILLER St.John's CollegeCambridge Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXIV, Issue 291, April 1959, Pages 286–287, https://doi.org/10.1093/ehr/LXXIV.291.286 Published: 01 April 1959
Endothelin‐1 and the kidney – beyond BP (2012)

Since its discovery over 20 years ago endothelin-1 (ET-1) has been implicated in a number of physiological and pathophysiological processes. Its role in the development and progression of chronic kidney disease (CKD) is well established and is an area of ongoing intense research. There are now available a number of ET receptor antagonists many of which have been used in trials with CKD patients and shown to reduce BP and proteinuria. However, ET-1 has a number of BP-independent effects. Importantly, and in relation to the kidney, ET-1 has clear roles to play in cell proliferation, podocyte dysfunction, inflammation and fibrosis, and arguably, these actions of ET-1 may be more significant in the progression of CKD than its prohypertensive actions. This review will focus on the potential role of ET-1 in renal disease with an emphasis on its BP-independent actions.
Principles of process research and chemical development in the pharmaceutical industry (1998)

The Ideal. Impure Thoughts. Going All the Way. Resolutions. Mirrors. Au Naturel. Radiant. License. The Future. Index.
Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells (2000)

Tumors produce a number of immunosuppressive factors that block the maturation of CD34+ stem cells into dendritic cells (DC). We hypothesized that tumors might also interfere with the maturation and/or function of human monocyte-derived DC. In contrast to stem cells, we found that CD14+ cells responded to tumor culture supernatant (TSN) by increasing expression of APC surface markers, up-regulating nuclear translocation of RelB, and developing allostimulatory activity. Although displaying these characteristics of mature DC, TSN-exposed DC lacked the capacity to produce IL-12, did not acquire full allostimulatory activity, and rapidly underwent apoptosis. The effects of TSN appeared to be specific for maturing DC, and were not reversed by Abs against known DC regulatory factors including IL-10, vascular endothelial growth factor, TGF-beta, or PGE2. Supernatants collected from nonmalignant cell sources had no effect on DC maturation. The altered maturation and early apoptosis of monocyte-derived DC may represent another mechanism by which tumors evade immune detection.
Pianola - Visualization of Multivariate Time-Series Security Event Data (2013)

Monitoring log files for network intrusions is unwieldy. To build a mental model of the log, an analyst is required to recognise continuous timelines and attack patterns from a dataset that is essentially limited to an ordered list of events. Information Visualization techniques arrange data into directly perceivable visual patterns that may alleviate some overheads associated with interpreting these datasets and improve the ability of users, especially those in resource-stretched Small and Medium sized Businesses (SMBs), to make sense of activity patterns in Intrusion Detection System (IDS) event logs. To this end, we discuss existing network security visualizations for IDS logs and after examining the strengths and drawbacks of those applications we have prototyped a visualization tool, Pianola, that arranges events on multiple timelines to reveal patterns both in time and across a network. The tool was evaluated against the traditional use of command-line interface (CLI)-based tools for analyzing network security events and displayed significant improvements in both recognition and detection of attacks and reduction in the users' subjective workload, measured using the NASA Task Load index (TLX).
A Major Role for a Set of Non-Active Site Mutations in the Development of HIV-1 Protease Drug Resistance (2003)

A major problem in the chemotherapy of HIV-1 infection is the appearance of drug resistance. In the case of HIV-1 protease inhibitors, resistance originates from mutations in the protease molecule that lower the affinity of inhibitors while still maintaining a viable enzymatic profile. Drug resistance mutations can be classified as active site or non-active site mutations depending on their location within the protease molecule. Active site mutations directly affect drug/target interactions, and their action can be readily understood in structural terms. Non-active site mutations influence binding from distal locations, and their mechanism of action is not immediately apparent. In this paper, we have characterized a mutant form of the HIV-1 protease, ANAM-11, identified in clinical isolates from HIV-1 infected patients treated with protease inhibitors. This mutant protease contains 11 mutations, 10 of which are located outside the active site (L10I/M36I/S37D/M46I/R57K/L63P/A71V/G73S/L90M/I93L) and 1 within the active site (I84V). ANAM-11 lowers the binding affinity of indinavir, nelfinavir, saquinavir, and ritonavir by factors of 4000, 3300, 5800, and 80000, respectively. Surprisingly, most of the loss in inhibitor affinity is due to the non-active site mutations as demonstrated by additional experiments performed with a protease containing only the 10 non-active site mutations (NAM-10) and another containing only the active site mutation (A-1). Kinetic analysis with two different substrates yielded comparable catalytic efficiencies for A-1, ANAM-11, NAM-10, and the wild-type protease. These studies demonstrate that non-active site mutations can be the primary source of resistance and that their role is not necessarily limited to compensate deleterious effects of active site mutations. Analysis of the structural stability of the proteases by differential scanning calorimetry reveals that ANAM-11 and NAM-10 are structurally more stable than the wild-type protease while A-1 is less stable. Together, the binding and structural thermodynamic results suggest that the non-active site mutants affect inhibitor binding by altering the geometry of the binding site cavity through the accumulation of mutations within the core of the protease molecule.
Differential responses of germinating<i>Venturia inaequalis</i>conidia to kresoxim-methyl (1998)

A new class of agricultural fungicides derived from strobilurins act as respiration inhibitors by binding to mitochondrial cytochrome b. The effects of the strobilurin, kresoxim-methyl, on conidia germination, mycelial growth and the protection of apple leaves from scab development were investigated for two isolates of Venturia inaequalis randomly selected from a culture collection. Inhibition of mycelial growth required relatively high doses of kresoxim-methyl (ED50=1 μg ml-1) for both isolates. In comparison, germination of conidia was highly sensitive for one of the isolates (ED50=0·005 μg ml-1), while the level of inhibition achieved for the second isolate was 60-fold less (ED50=0·3 μg ml-1). As deduced from identical sequences of cytochrome b cDNAs prepared from both isolates, the different responses of germinating conidia to kresoxim-methyl were not caused by differences in the sequence of cytochrome b as the target site for strobilurin action. Strong synergistic effects of salicylhydroxamic acid on kresoxim-methyl inhibitory potency suggested that the reduced kresoxim-methyl sensitivity observed for germinating conidia was caused by interference of the alternative respiratory pathway with inhibitor action. However, this mechanism of target site circumvention in germinating conidia had no adverse effects on the protection of apple leaves from scab infection by kresoxim-methyl. © 1998 Society of Chemical Industry
Autoantibodies to Islet Amyloid Polypeptide in Diabetes (1991)

Islet amyloid polypeptide (IAPP) is the constituent peptide of amyloid in pancreatic islets of Type 2 diabetic patients and in insulinomas. Amyloid formation in Type 2 diabetes is associated with islet cell destruction which may promote formation of autoantibodies to IAPP. An ELISA method has been developed to detect IAPP autoantibodies and used to assay serum from 80 non-diabetic subjects, 49 Type 1 and 228 Type 2 diabetic patients, and 10 patients with insulinomas. Microtitre plates coated with IAPP 1-37 were used to detect antibody binding followed by an alkaline phosphatase conjugated anti-human IgG. ELISA binding decreased with sample dilution and with pre-incubation of the samples with IAPP. The optical density of the substrate reaction was compared with results from a standard serum from a non-diabetic subject (OD ratio). Elevated OD ratios were detected in some subjects from each patient group but the Type 2 diabetic group had significantly higher titres than the non-diabetic subjects (p less than 0.001). The OD ratio was elevated (greater than mean + 2SD non-diabetic group) in 15% of Type 2 and 18% of Type 1 diabetic patients and in 20% with insulinomas. IAPP antibody levels did not correlate with age or gender of subjects, or duration of diabetes. IAPP autoantibodies could be an additional marker for B-cell damage in diabetes.
Animal and plant mitochondria contain specific thioredoxins (1989)

Thioredoxins have been purified from pig heart and potato tuber mitochondria which differ in chromatographic behaviour, enzyme activating capacity, and slightly higher molecular mass (Mr = 12,500) from the major thioredoxin(s) present in mitochondria-free fractions of the same tissue. Both mt-thioredoxins can serve as hydrogen donor for E. coli ribonucleotide reductase but only the plant protein activates spinach chloroplast NADP malate dehydrogenase in vitro. Mitochondrial target enzymes specifically activated by thioredoxin have not as yet been identified.
SoCECT: System on Chip Embedded Core Test (2008)

This paper presents SoCECT (system on chip embedded core test), a novel test controller architecture that allows multiple IEEE 1500 wrapped cores within a SoC to be tested concurrently. SoCECT makes use of the IEEE 1149.1 JTAG state machine to operate the test controller and also to allow for future integration with an IEEE P1687 interface. SoCECT also includes a test access mechanism (TAM) methodology(distributed architecture) that reuses the physical connections of the SoC system bus to provide an efficient transport medium for structural and functional test vectors between the embedded test controller and IEEE 1500 wrapped cores.
A Large-Scale Reconfigurable Analog Signal Processor (RASP) IC (2006)

The reconfigurable analog signal processor (RASP), one of the first large-scale field-programmable analog arrays (FPAAs), is composed of 56 computational analog blocks (CABs). Each CAB contains various levels of analog computational granularity utilizing over 50,000 programmable analog elements. Bias currents are programmable to within 0.2% from 100 pA to greater than 3 muA. Internal bandwidths are greater than 50 MHz, and the kT/C noise can be adjusted using the drawn capacitances and routing network parasitics. A range of compiled circuits and resulting signal processing systems are presented
Immunohistochemical demonstration of immunoglobulins and albumin in human brain tumors. (1989)

Routinely processed biopsy material, including 56 gliomas of varying malignancy, 10 meningiomas, 10 brain metastases and 12 brain abscesses, was examined for the presence and distribution of IgG, IgA, IgM, IgD and albumin using the unlabeled antibody peroxidase-antiperoxidase technique. In all specimens the deposition of stained immunoglobulins (Ig) was strictly associated with that of albumin even on cell surfaces. Thus there was no evidence for specific membrane binding or cytotoxicity. The interstitial proteins demonstrated are most likely derived from the plasma by blood-brain barrier breakdown which occurs in nearly all tumors and abscesses. Obvious intracellular staining for Ig and albumin was seen in glioma cells and astrocytes only. This is suggested to be due to active protein uptake as a specific feature of astrocyte differentiation which decreases with malignancy and is lost in glioblastomas. Evidence for local Ig production was found in 8 out of 10 metastases with striking IgG- and IgA-positive plasma cells within lymphocytic infiltrations and in one meningioma showing conspicuous plasma cells components. No glioma contained Ig-bearing plasma cells, though round cell infiltrations were present in 64% of the unselected cases. The significance of these findings regarding the immunological situation in brain tumors is briefly discussed.
Probabilistic Forecasting (2014)

A probabilistic forecast takes the form of a predictive probability distribution over future quantities or events of interest. Probabilistic forecasting aims to maximize the sharpness of the predictive distributions, subject to calibration, on the basis of the available information set. We formalize and study notions of calibration in a prediction space setting. In practice, probabilistic calibration can be checked by examining probability integral transform (PIT) histograms. Proper scoring rules such as the logarithmic score and the continuous ranked probability score serve to assess calibration and sharpness simultaneously. As a special case, consistent scoring functions provide decision-theoretically coherent tools for evaluating point forecasts. We emphasize methodological links to parametric and nonparametric distributional regression techniques, which attempt to model and to estimate conditional distribution functions; we use the context of statistically postprocessed ensemble forecasts in numerical weather prediction as an example. Throughout, we illustrate concepts and methodologies in data examples.
H.264-based Hierarchical Lossless Coding System with New Intra Prediction Method (2011)

Loss less coding is an important technique that it will efficiently compress valuable information without any loss. This technique plays an important role for the medical applications that the content cannot allow any distortions. Recently, the advance video coding (H.264/AVC), which is well known to provide high compression ratio has been applied to loss less coding system. In this paper, we proposed a hierarchical loss less video coding structure based on H.264/AVC to improve the compression ratio. The base layer is the H.264/AVC lossy coding system, and the enhancement layer is the loss less entropy coding system used to encode the error that made by DCT and quantization. Moreover, to improve the coding efficiency we also proposed a new intra prediction process to replace the sample-by-sample DPCM concept. The simulation results show that the proposed methods have better performance than DPCM-Based H.264/AVC loss less coding system.
A heuristic planner and an executive for mobile robot control (1985)

A path planner and an execution system are proposed for automatic indoor guidance. The planner creates a route plan in two levels of hierarchy. The first level selects doors to pass through, minimizing the total number of doors, and the other generates a near shortest trajectory inside a room. In order to reduce search space and computation time for the planning, heuristic pruning strategies are used in a path search procedure. The execution system performs hierarchical plan repair with regard to the plan levels against unexpected events by detecting obstacles. Simulation tests are conducted to evaluate its execution behaviour with various representations of terrain, unknown obstacles, and an omnidirectional vehicle robot equipped with a sonic range finder for obstacle detection. The results exhibit the effectiveness of simple heuristics in combination with a sonic range finder that provides an adequate amount of data from multiple viewpoints.
Experimental Endoscopic Endovascular Cannulation: A Novel Approach to Thrombolysis in Retinal Vessel Occlusion (2011)

Endoscopically guided puncture of retinal microvessels is feasible and can be performed through a pars plana entry without additional micromanipulation devices. This novel technique may be a safe and effective approach to catheter-directed endovascular thrombolysis in retinal vascular occlusive diseases.
10-Year Experience with Extracorporeal Shockwave Lithotripsy in the State of Colorado (2000)

Over the 10 years since the introduction of WSL in Colorado, there has been a gradual increase in its utilization. This higher utilization is probably multifactorial. Patients undergoing SWL have a strong desire to prevent future stone episodes and are very interested in medical prophylaxis of their stone disease.
Both Sides of the Green Line (1990)

Orientation at a small, cozy hotel in Foggy Bottom, not far from the State Department.Fourteen academics from around the country, all with some experience in the Middle East, make up our group.In preparation for our study tour to Israel and the Occupied Territories, U.S. officials, Palestinian and Israeli representatives present a series of excellent briefings.A former adviser to Henry Kissinger, now a private consultant, reports that the United States has neglected and abused Jordan because of its close ties to Iraq.King Hussein is "turning back to his people."Anti-Americanism in Amman is more blatant than ever before.The United States does not have a Middle East policy but rather a domestic American policy about the Middle East, with little concern
Analog VLSI current mode implementation of artificial neural networks (2002)

In this paper we examine all current-mode building blocks for implementation of artificial neural networks. The building blocks proposed include a current dependent pulse generator, a pulse frequency modulator used to multiply incoming pulses with variable weights, and a current in/current out sigmoid function circuit. The circuits can be easily implemented in a standard CMOS VLSI process. Simulations are presented to confirm the validity of the proposed circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Emerging drugs for respiratory syncytial virus infection (2009)

Although respiratory syncytial virus (RSV) was discovered > 40 years ago, treatment remains largely supportive. There are no safe and effective vaccines or specific treatments other than prophylaxis with passive antibody therapy (palivizumab). However, there are good reasons to think that the scene may soon change. As the pace of development of anti-viral drugs accelerates and optimism over vaccines increases, novel therapies are set to make a major impact in the management of this very common infection. The use and effect of such interventions are not easy to anticipate, but could ultimately include the interruption of RSV's transmission resulting in profound changes to the impact of RSV on human health.
Copper-Catalyzed Aerobic Oxidative Synthesis of Primary Amides from (Aryl)methanamines (2012)

A copper-catalyzed aerobic oxidative method for the synthesis of primary aryl amides has been developed, and the direct oxygenation of (aryl)methanamines to primary aryl amides by molecular oxygen showed convenient, practical, and environment-friendly advantages. This method will find wide application in chemistry and biology.
TADDOLe, ihre Derivate und Analoga – vielseitige chirale Hilfsstoffe (2001)

TADDOLe – aus Acetalen oder Ketalen von Weinsäureestern und aromatischen Grignard-Verbindungen in großer Vielfalt herstellbare Diole mit (Diarylhydroxymethyl)-Gruppen in trans-Stellung an einem 1,3-Dioxolanring – sind vielseitig anwendbare chirale Hilfsstoffe. Dieser Aufsatz behandelt nach einer historischen Rückschau die Herstellung von TADDOLen und strukturellen Analoga, darunter TADDOLe als N-, P-, O- und S-Liganden für Metalle. Kristallstrukturanalysen zufolge stehen die Heteroatome an den Diarylmethyl-Gruppen fast immer nah beieinander, sie sind durch H-Brücken verknüpft und prädisponiert für die Bildung von Chelatkomplexen, in denen sich das Metallzentrum in einer propellerartigen chiralen Umgebung befindet. Anwendungen für TADDOL-Derivate in der enantioselektiven Synthese erstrecken sich vom Einsatz als stöchiometrische chirale Reagentien über Lewis-Säure-vermittelte Reaktionen bis hin zu katalytischen Hydrierungen und stereoregulär polymerisierenden Metathesen, wobei bisher Derivate und Komplexe folgender Metalle genutzt wurden: Li, B, Mg, Al, Si, Cu, Zn, Ce, Ti, Zr, Mo, Rh, Ir, Pd, Pt. Entsprechend groß ist die Zahl der mit TADDOLen stereoselektiv durchgeführten Reaktionen. Auch konnten leicht polymerisierbare und aufpfropfbare TADDOL-Derivate hergestellt und in festphasengebundene Katalysatoren überführt werden. Es ergaben sich einfach oder dendritisch an Polystyrol oder poröses Silicagel gebundene Katalysatoren mit hoher Standfestigkeit bei der Vielfachanwendung in Ti-TADDOLat-vermittelten Reaktionen. TADDOLe zeigen ferner ungewöhnliche Eigenschaften, die sie für Anwendungen in den Materialwissenschaften und in der supramolekularen Chemie nutzbar machen; so sind sie die bisher effektivsten Dotierstoffe zur Phasenumwandlung achiraler (nematischer) in chirale (cholesterische) Flüssigkristalle. Die nicht an der intramolekularen H-Brücke beteiligte OH-Gruppe der TADDOLe neigt dazu, intermolekulare H-Brückenacceptoren zu binden. Dadurch bilden sich beim Kristallisieren enantioselektiv Einschlussverbindungen, die zur äußerst vielseitigen Trennung von racemischen Gemischen dienen, welche sich nicht für die klassische Kristallisation diastereomerer Salze eignen. Der hohe Schmelzpunkt der TADDOLe ermöglicht sogar destillative Racematspaltungen! Wirt-Gast-Verbindungen von TADDOLen mit achiralen Partnern schließlich können für enantioselektive Photoreaktionen verwendet werden.