gebhart/patrepeval huggingface dataset:
Charged Aerosol Detection in Pharmaceutical Analysis (2017)

This chapter examines the operation and use of charged aerosol detection (CAD) in a regulated pharmaceutical environment, addresses method development, validation, and transfer, and highlights a few examples illustrating some advantages of using CAD in the pharmaceutical laboratory. Analytical method validation (AMV) is one part of the overall validation process that also includes software qualification, analytical instrumentation qualification (AIQ), and system suitability. During AMV, several analytical performance characteristics are potentially evaluated, including limits of detection (LOD) and limits of quantitation (LOQ), depending upon the requirements of the method. With a CAD dynamic range of four orders of magnitude, determining the LOQ and LOD does not prove to be an issue for most compounds at the 0.1 and 0.05% concentration levels. The ion analysis method selected for the formulation process is typically used in downstream processes when the active pharmaceutical ingredient (API) is monitored to ensure its safety, quality, strength, and purity.
Prostacyclin Prevents Pericyte Loss and Demyelination Induced by Lysophosphatidylcholine in the Central Nervous System (2015)

Pericytes play pivotal roles in physiological and pathophysiological conditions in the central nervous system. As pericytes prevent vascular leakage, they can halt neuronal damage stemming from a compromised blood-brain barrier. Therefore, pericytes may be a good target for the treatment of neurodegenerative disorders, although evidence is lacking. In this study, we show that prostacyclin attenuates lysophosphatidylcholine (LPC)-mediated vascular dysfunction through pericyte protection in the adult mouse spinal cord. LPC decreased the number of pericytes in an in vitro blood-brain barrier model, and this decrease was prevented by iloprost treatment, a prostacyclin analog. Intrathecal administration of iloprost attenuated vascular barrier disruption after LPC injection in the mouse spinal cord. Furthermore, iloprost treatment diminished demyelination and motor function deficits in mice injected with LPC. These results support the notion that prostacyclin acts on pericytes to maintain vascular barrier integrity.
Heat‐ and water‐proof quantum dot/siloxane composite film: Effect of quantum dot–siloxane linkage (2017)

Abstract We report on the effect of linkage between quantum dot (QD) and siloxane matrix by preparing two different QD/siloxane films. One has chemical linkages between QD and siloxane matrix, and the other has no chemical linkages between QD and siloxane matrix. The QD/siloxane (methacryl) film, which has the chemical linkages, exhibits no degradation of photoluminescence (PL) quantum yield (QY) under heat or moisture condition for over 1 month, while the QD/siloxane (epoxy) film, which has no linkages, shows drastic decreased of PL QY. The chemical linkages between QD and siloxane matrix that makes effective siloxane passivation layer intact on the surface of QDs in QD/siloxane (methacryl) film. Given its exceptional stability with the help of linkages between QD and siloxane matrix, we expect that the QD/siloxane (methacryl) film is best fitted in PL‐type down‐conversion layer for display applications.
Variation in the Biochemical/Biophysical Properties of Mutant Superoxide Dismutase 1 Enzymes and the Rate of Disease Progression in Familial Amyotrophic Lateral Sclerosis Kindreds (1999)

Mutations in superoxide dismutase 1 (SOD1) polypeptides cause a form of familial amyotrophic lateral sclerosis (FALS). In different kindreds, harboring different mutations, the duration of illness tends to be similar for a given mutation. For example, patients inheriting a substitution of valine for alanine at position four (A4V) average a 1.5 year life expectancy after the onset of symptoms, whereas patients harboring a substitution of arginine for histidine at position 46 (H46R) average an 18 year life expectancy after disease onset. Here, we examine a number of biochemical and biophysical properties of nine different FALS variants of SOD1 polypeptides, including enzymatic activity (which relates indirectly to the affinity of the enzyme for copper), polypeptide half-life, resistance to proteolytic degradation and solubility, in an effort to determine whether a specific property of these enzymes correlates with clinical progression. We find that although all the mutants tested appear to be soluble, the different mutants show a remarkable degree of variation with respect to activity, polypeptide half-life and resistance to proteolysis. However, these variables do not stratify in a manner that correlates with clinical progression. We conclude that the basis for the different life expectancies of patients in different kindreds of sod1-linked FALS may result from an as yet unidentified property of these mutant enzymes.
OFDM-IDMA with User Grouping (2013)

A generalized version of orthogonal frequency division multiplexing interleave division multiple access (OFDM-IDMA) referred to as grouped OFDM-IDMA (G-OFDM-IDMA) is introduced in this paper. By dividing users into groups and transmitting each group's data only on some (as opposed to all) subcarriers, G-OFDM-IDMA can have much lower decoding complexity compared with conventional OFDM-IDMA while preserving the bit error probability (BEP) performance and the bandwidth efficiency. The user grouping problem is formulated into an integer linear programming problem whose suboptimal solution is proposed and compared with the lower bound. The optimization complexity issue is also addressed. Simulations are carried out to test the performance of G-OFDM-IDMA under various system configurations. It is observed that up to 80% complexity could be saved when the conventional OFDM-IDMA is substituted by G-OFDM-IDMA configured according to the suboptimal grouping solution.
Large-area low-temperature ultrananocrystalline diamond (UNCD) films and integration with CMOS devices for monolithically integrated diamond MEMS/NEMS-CMOS systems (2009)

Because of exceptional mechanical, chemical, and tribological properties, diamond has a great potential to be used as a material for the development of high-performance MEMS and NEMS such as resonators and switches compatible with harsh environments, which involve mechanical motion and intermittent contact. Integration of such MEMS/NEMS devices with complementary metal oxide semiconductor (CMOS) microelectronics will provide a unique platform for CMOS-driven commercial MEMS/NEMS. The main hurdle to achieve diamond-CMOS integration is the relatively high substrate temperatures (600-800°C) required for depositing conventional diamond thin films, which are well above the CMOS operating thermal budget (400 °C). Additionally, a materials integration strategy has to be developed to enable diamond-CMOS integration. Ultrananocrystalline diamond (UNCD), a novel material developed in thin film form at Argonne, is currently the only microwave plasma chemical vapor deposition (MPCVD) grown diamond film that can be grown at 400 °C, and still retain exceptional mechanical, chemical, and tribological properties comparable to that of single crystal diamond. We have developed a process based on MPCVD to synthesize UNCD films on up to 200 mm in diameter CMOS wafers, which will open new avenues for the fabrication of monolithically integrated CMOS-driven MEMS/NEMS based on UNCD. UNCD films were grown successfully on individual Si-based CMOS chips and on 200 mm CMOS wafers at 400 °C in a MPCVD system, using Ar-rich/CH4 gas mixture. The CMOS devices on the wafers were characterized before and after UNCD deposition. All devices were performing to specifications with very small degradation after UNCD deposition and processing. A threshold voltage degradation in the range of 0.08-0.44V and transconductance degradation in the range of 1.5-9% were observed.
Three-dimensional stability analysis of DC power electronics based systems (2002)

Power electronics based power distribution systems are becoming increasingly common, particularly in marine and aerospace applications. Stability analysis of this class of systems is crucial due to the potential for negative impedance instability. Existing techniques of stability analysis introduce artificial conservativeness, are sensitive to component grouping, and at the same time do not explicitly address uncertainties and variations in operating point. Recently, a new stability criterion which reduces artificial conservativeness and is also insensitive to component grouping has been set forth along with a means of readily establishing design specifications from an arbitrary stability criterion which specifically includes a provision to incorporate uncertainty, parameter variation, and nonlinearities. Therein, the method is used to develop a load admittance constraint based on a generalized source impedance. In this paper, that work is further explained and the converse problem, that of generating a constraint on the source impedance from the load admittance, is also illustrated.
Introduction (1990)

In the age of glasnost', many of the "truths" of the past are being reexamined and found false. One of the casualties of the new openness has been the reporting of statistics on a wide range of topics, and in this month's lead article Denisova provides startling insight into the sorry state of statistics on the schools. This is not the first exposé of the falsity of earlier figures, but seeing the data arrayed together as they are here has a greater impact. The physical conditions in which many children are obliged to spend their schooldays range from inadequate to dangerous, with more than a million pupils still studying in buildings that should be demolished. Rural schools, as the articles in our February issue this year showed, are in especially bad condition. This not only harms the future prospects of the children who go to village schools, it also discourages people from moving to, or remaining in, rural areas where their labor is sorely needed. The size of the problem is illustrated by Denisova's comment that nine out of ten of the schools attended by sixteen million pupils do not have a sewage system, while four thousand village schools do not even have electricity.
Ecology of Plant Pathogens (1994)

1: Ecological Determinants of Plant Pathogen Populations 2: All creatures unitary and modular, J.H. Andrews 3: The biological environment and pathogen population dynamics: Uncertainty, coexistance and competition, M.W. Shaw and J.C. Peters 4: The microchemistry of plant/micro-organism interactions, T. Shepherd 5: Evaluation of plant pathogens in complex ecosystems, J.M. Lenne, D.M. Teverson and M.J. Jeger 6: Humidity and fungal diseases of plants - problems, J.G. Harrison, R. Lowe and N.A. Williams 7: Methodology 8: Interaction of Bacillus species with phytopathogenic fungi - Methods of analysis and manipulation for biocontrol purposes, S.G. Edwards, T. McKay and B. Seddon 9: Methods for detecting Armillaria mellea, R.T.V. Fox, H.M. Manley, A. Culham, K. Hahne and A.I. Tiffin 10: Identification of colonizing forms of Trichoderma species isolated from mushroom compost, P.R. Mills and S. Muthumeenakshi 11: Use of the polymerase chain reaction for identifying plant pathogens, E.Ward 12: Quantifying Polymyxa betae and BNYVV in soil, G. Tuitert 13: Aspects of Autecology 14: Spore dispersal: Environmental and biological factors, H.A. McCartney 15: Latency and quiescence in survival and success of fungal plant pathogens, B. Williamson 16: Aspects of the autecology of the take-all fungus, D. Hornby 17: Autecology of foliar pseudomonads, S.S. Hirano and C.D. Upper 18: Autecology and evolution of the Witches' Broom (Crinipellis perniciosa) Pathogen of Cocoa, G.W. Griffith, E. Bravo-Velasquez, F.J. Wilson and J.N. Hedger 19: The ecology of african cassava mosaic geminivirus, D. Fargette and J.M. Thresh 20: Microbial Interactions 21: Straw disposal and cereal diseases, J.F. Jenkyn, R.J. Gutteridge and M. Jalaluddin 22: The cereal Fusarium complex, D.W. Parry, T.R. Pettit, P. Jenkinson and A.K. Lees 23: Fungal interactions on living and necrotic leaves, J. Kohl and N.J. Fokkema 24: Biological control of Erwinia amylovora with Erwinia herbicola, H.A.S. Epton, M. Wilson, S.L. Nicholson and D.C. Sigee
Evaluation of a dialogue manager for a mobile robot (2013)

This paper presents an evaluation of the dialogue manager (DM) used on Carl, a prototype of an intelligent service robot, designed and developed having in mind hosting tasks in a building or event. The developed DM, based on the “Information State” approach, is described. In an experimental evaluation, in which 10 participants attempted to complete several interaction tasks with the robot, 81% of tasks were performed successfully. The results of an usability evaluation are also presented and discussed.
Inversion of nonhyperbolic moveout in transversely isotropic media (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Inversion of nonhyperbolic moveout in transversely isotropic mediaAuthors: Vladimir GrechkaIlya TsvankinVladimir GrechkaCenter for Wave Phenomena, Colomdo School of Mines, Golden, CO 80401 and Ilya TsvankinCenter for Wave Phenomena, Colomdo School of Mines, Golden, CO 80401https://doi.org/10.1190/1.1885752 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885752FiguresReferencesRelatedDetailsCited byMachine-learning based prediction of phase velocities and phase angles from group velocities and group angles in an anisotropic elastic medium — A feasibility studySubhashis Mallick, Prayas Rath, Mingliang Liu, Scott A. Darhower, Chau Duc Minh Ha, Anthony Manuel Moraes, Rodrigo Correa Rangel, and Mohit Ayani10 August 2019References2 October 2014Numerical modeling of PP- and PS-wave azimuthal anisotropy in HTI media30 December 2012 | Applied Geophysics, Vol. 9, No. 4Anisotropic prestack depth migration in practice21 February 2019 | ASEG Extended Abstracts, Vol. 2003, No. 211. Reservoir Geophysics21 March 2012Transverse isotropy versus lateral heterogeneity in the inversion of P-wave reflection traveltimesVladimir Y. Grechka7 February 2012 | GEOPHYSICS, Vol. 63, No. 1 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Vladimir Grechka and Ilya Tsvankin, (1997), "Inversion of nonhyperbolic moveout in transversely isotropic media," SEG Technical Program Expanded Abstracts : 1685-1688. https://doi.org/10.1190/1.1885752 Plain-Language Summary PDF DownloadLoading ...
IPFIX Implementation Guidelines (2006)

The IP Flow Information eXport (IPFIX) protocol defines how IP Flow
information can be exported from routers, measurement probes or other
devices. This document provides guidelines for the implementation and
use of the IPFIX protocol. A set of these guidelines refers to the
implementation on middleboxes, such as firewalls, network address
translators, tunnel endpoints, packet classifiers, etc.
Detection of West Nile Virus Infection in Birds in the United States by Blocking ELISA and Immunohistochemistry (2003)

A blocking ELISA targeting an immunodominant West Nile epitope on the West Nile Virus NS1 protein was assessed for the detection of West Nile-specific antibodies in blood samples collected from 584 sentinel chickens and 238 wild birds collected in New Jersey from May-December 2000. Ten mallard ducks (Anas platyrhynchos) experimentally infected with West Nile virus and six uninfected controls were also tested. The ELISA proved specific in detecting WNV antibodies in 9/10 chickens and 4/4 wild birds previously confirmed as positive by Plaque Reduction Neutralization test (PRNT) at the Center for Disease Control, Division of Vector Borne Diseases, Fort Collins, CO, USA (CDC). Nine out of the ten experimentally infected mallard ducks also tested positive for WN antibodies in the blocking ELISA, while 6/6 uninfected controls did not. Additionally, 1705 wild birds, collected in New Jersey from December 2000-November 2001 and Long Island, New York between November 1999 and August 2001 were also tested for WN antibodies by the blocking ELISA. These tests identified 30 positive specimens, 12 of which had formalin-fixed tissues available to allow detection of WN specific viral antigen in various tissues by WNV-specific immunohistochemistry. Our results indicate that rapid and specific detection of antibodies to WN virus in sera from a range of avian species by blocking ELISA is an effective strategy for WN Virus surveillance in avian hosts. In combination with detection of WN-specific antigens in tissues by immunohistochemistry (IHC) the blocking ELISA will also be useful for confirming WN infection in diseased birds.
The impact of chronic stress on the rat brain lipidome (2015)

Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision making and emotional responses, and may even predispose for pathological processes, such as Alzheimer's disease and depression. Lipids are a major constituent of the brain and specifically signaling lipids have been shown to regulate brain function. Here, we used a mass spectrometry-based lipidomic approach to evaluate the impact of a chronic unpredictable stress (CUS) paradigm on the rat brain in a region-specific manner. We found that the prefrontal cortex (PFC) was the area with the highest degree of changes induced by chronic stress. Although the hippocampus presented relevant lipidomic changes, the amygdala and, to a greater extent, the cerebellum presented few lipid changes upon chronic stress exposure. The sphingolipid and phospholipid metabolism were profoundly affected, showing an increase in ceramide (Cer) and a decrease in sphingomyelin (SM) and dihydrosphingomyelin (dhSM) levels, and a decrease in phosphatidylethanolamine (PE) and ether phosphatidylcholine (PCe) and increase in lysophosphatidylethanolamine (LPE) levels, respectively. Furthermore, the fatty-acyl profile of phospholipids and diacylglycerol revealed that chronic stressed rats had higher 38 carbon(38C)-lipid levels in the hippocampus and reduced 36C-lipid levels in the PFC. Finally, lysophosphatidylcholine (LPC) levels in the PFC were found to be correlated with blood corticosterone (CORT) levels. In summary, lipidomic profiling of the effect of chronic stress allowed the identification of dysregulated lipid pathways, revealing putative targets for pharmacological intervention that may potentially be used to modulate stress-induced deficits.
A Photoprotein in Mouse Embryonic Stem Cells Measures Ca2+ Mobilization in Cells and in Animals (2010)

Exogenous expression of pharmacological targets in transformed cell lines has been the traditional platform for high throughput screening of small molecules. However, exogenous expression in these cells is limited by aberrant dosage, or its toxicity, the potential lack of interaction partners, and alterations to physiology due to transformation itself. Instead, primary cells or cells differentiated from precursors are more physiological, but less amenable to exogenous expression of reporter systems. To overcome this challenge, we stably expressed c-Photina, a Ca(2+)-sensitive photoprotein, driven by a ubiquitous promoter in a mouse embryonic stem (mES) cell line. The same embryonic stem cell line was also used to generate a transgenic mouse that expresses c-Photina in most tissues. We show here that these cells and mice provide an efficient source of primary cells, cells differentiated from mES cells, including cardiomyocytes, neurons, astrocytes, macrophages, endothelial cells, pancreatic islet cells, stably and robustly expressing c-Photina, and may be exploited for miniaturized high throughput screening. Moreover, we provide evidence that the transgenic mice may be suitable for ex-vivo bioimaging studies in both cells and tissues.
Arms control: theory and practice (1988)

Journal Article Arms control: theory and practice Get access Arms control: theory and practice. By Michael J. Sheehan. New York, Oxford: Blackwell. 1988. 188pp. Index. £27.50; ISBN 0631 14164 2. Pb.: £9.95; ISBN 631 16059 0. Trevor Taylor Trevor Taylor 1Staffordshire Polytechnic Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 65, Issue 1, January 1988, Page 124, https://doi.org/10.2307/2620998 Published: 01 January 1988
Properties of the Optokinetic Motor Fibres in the Rock Lobster: Build-Up, Flipback, Afterdischarge and Memory, Shown by Their Firing Patterns (1972)

ABSTRACT The properties of sets of motor fibres responding to both clockwise and anticlockwise rotation have been studied in the oculomotor nerve of the rock lobster. There are probably three, but perhaps four, units in each set. None of these fibres has statocyst input, but there is weak input onto the tonio fibres from the antennal joints such that the eye turns in the direction toward which e antenna points. Many preparations show bilateral visual input onto all fibres but the degree of coupling between the eyes is very variable, and at times can be nearly totally absent. Depending on the speed of rotation the fibres show a gradual build-up in frequency, during rotation in the preferred direction, interrupted by flipbacks. During the fast stage of the resulting nystagmic movements all agonistic fibres can be completely inhibited and all antagonistic ones can be activated, usually for a period of about 0·5 sec. Fibre activity is demonstrated which appears to underlie an ‘optokinetic memory’ of contrasting target position in the visual field. It consists of (a) very prolonged afterdischarges for a stationary striped pattern (b) resumption of discharges at an appropriate frequency after dark periods up to 2 min, and (c) adjustment of such frequencies to changes in stripe position during the dark period. The fibres show habituation to repeated stripe movement but the response can be dishabituated by passive rotation of the animal. The largest visual responses were obtained to intermediate speeds of stripe rotation (about 2°/sec).
Amorphous Hydrogenated Silicon Nitride Deposited by Mercury Photosensitization Chemical Vapour Deposition for Optoelectronic Applications (1995)

In this work we focus on the properties of amorphous hydrogenated silicon nitride (a-SiN:H) films deposited by mercury sensitization Photo-Chemical Vapour Deposition (Photo-CVD) utilizing SiH4 and NH3 and their suitability for the realization of III-V semiconductor optoelectronic devices (dielectric insulation, protection of reverse junctions, process mask, selective regrowth, antireflection coating). Using proper deposition conditions we have obtained a-SiN:H films with breakdown field of 8.9 MV/cm, good spatial uniformity of the dielectric properties, refractive index of 1.85 at 1535 nm, quasi-stoichiometric composition (Si/N=0.8), energy gap of 4.22 eV and density of 2.51 g/cm3, absence of pores and bubbles. We can reproduce film thickness, refractive index and energy gap within ±3%, ±0.005 and 0.05 eV respectively. SiN/InP structures similar to the actual optoelectronic devices have been employed in order to test mechanical adhesion and thickness of the a-SiN:H film grown on vertical facets. A-SiN:H films deposited in the optimized conditions have been successfully used in the previously mentioned applications.