gebhart/patrepeval huggingface dataset:
Measurement of Viscoelastic Properties of Arteries in the Living Dog (1968)

Dynamic elastic moduli (E dyn ) and viscous moduli (ηω) of the arterial wall were obtained at a number of sites of the systemic vascular tree of living dogs anesthetized with pentobarbital. Constants were calculated using the first harmonics of pressure and diameter obtained from a Fourier analysis of simultaneously recorded pulse waves. The means and standard errors of E dyn , in dynes cm -2 x 10 6 , obtained at mean blood pressures ranging from 87 to 130 mm Hg and pulse frequencies from 1.1 to 2.8 cps were: 3.0±0.33 (9 midthoracic aortas), 9.8±1.2 (7 midabdominal aortas), 11.0 (4 iliac arteries), and 12.3±1.2 (11 femoral arteries). The viscous modulus was approximately 9% of E dyn in the midthoracic aorta and approximately 12% of E dyn in the abdominal and femoral arteries. Pulse wave velocities calculated from values of E dyn and relative wall thickness by the Moens-Korteweg equation agreed with accepted values. A Fourier analysis of pressure and diameter waves was shown to be unsatisfactory for determining the frequency dependence of viscoelastic constants because of anomalous behavior of the viscoelastic parameters. In the midthoracic aorta this behavior may have been partly attributable to artefact; however, there was strong evidence that elsewhere nonlinear pressure and diameter relationships interfered with the accurate determination of the relatively small, higher-order harmonic components.
Energy management and dynamic control in Composite Energy Storage System for micro-grid applications (2010)

Micro-grids that are infrastructure for implementation and utilization of renewable energy sources require high-power-density, high-energy-density storage. Composite Energy Storage System (CESS) is a combination of various energy storage technologies that offers not only above performance but also high efficiency and long life. For system management of CESS, problems of energy management and dynamic control are questioned. In this paper, we propose the Energy Manager that support both short-term and long-term requirements of the CESS. Dynamic control of specific Dual-Active-Bridge (DAB) converters in order to provide compatibility with commands from Energy Manager is presented.
Characterization of phototrophic biofilms deteriorating Indian stone monuments, their response to heat stress and development of a non-invasive remediation strategy (2014)

The Eastern India is a valuable cultural heritage site rich of monuments that represent the past Indian art. These monuments are made up by sandstone or limestone or mortar and are interested by an extensive cover of phototrophic biofilms on the exposed surfaces that caused their disfiguration and biodeterioration (Samad & Adhikary 2008). The biofilms are composed mainly by cyanobacteria in association with bacteria, fungi and some microalgae (Gaylarde et al. 2001, Crispim et al. 2003). The biofilm-forming cyanobacteria are of particular scientific interest due to their survival ability to withstand a variety of stresses like high temperature, high light intensity coupled with extreme dryness. However, they occurred as dried and consequently inactive biofilms on exterior of stone structures during summer but can recover quickly if water is suddenly available after rain events. The dominating stress tolerant cyanobacteria upon these stone monuments of the tropics are filamentous and heterocystous one with thick sheaths that presents UV sunscreen/sun blocking pigments fundamental at these extreme conditions (Adhikary & Sahu 1998, Gupta & Agrawal 2008,tion to which the stone monuments are exposed represent selective factors for the growth of microorganisms and only these stress tolerant cyanobacteria are able to survive, although in a vegetative state (Samad & Adhikary 2008, Keshari & Adhikary 2013). Stress tolerance is the series of alteration in the organisms at the morphological and molecular levels, due to their adaptation to a changed environment. In order to better understand the biodeterioration process of the stone monuments studies were carried out to characterize the microorganisms present in biofilms collected from a statue and from an Indian Temple. Due to the fact that sometimes temperature exceeds 65°C during summer months, the cyanobacterial response to heat stress has been investigated. In order to develop new non-invasive methodologies for the remediation of these valuable stone monuments a carbon based nanomaterial, the graphene oxide, was tested on the biofilms in order to investigate the potentiality as biocide to be used for the restoration of the valuable surfaces.
First-Principles Determination of Ultrahigh Thermal Conductivity of Boron Arsenide: A Competitor for Diamond? (2013)

We have calculated the thermal conductivities (κ) of cubic III-V boron compounds using a predictive first principles approach. Boron arsenide is found to have a remarkable room temperature κ over 2000 W m(-1) K(-1); this is comparable to those in diamond and graphite, which are the highest bulk values known. We trace this behavior in boron arsenide to an interplay of certain basic vibrational properties that lie outside of the conventional guidelines in searching for high κ materials, and to relatively weak phonon-isotope scattering. We also find that cubic boron nitride and boron antimonide will have high κ with isotopic purification. This work provides new insight into the nature of thermal transport at a quantitative level and predicts a new ultrahigh κ material of potential interest for passive cooling applications.
Membrane potential‐dependent calcium transport in right‐side‐out plasma membrane vesicles from <i>Zea mays</i> L. roots (1994)

Summary Right‐side‐out plasma membrane vesicles isolated from Zea mays roots were used to study membrane potential (ΔΨ)‐dependent Ca 2+ transport. Membrane potentials were imposed on the vesicles using either K + concentration gradients and valinomycin or SCN concentration gradients, and the size of the imposed ΔΨ was measured with [ 14 C]tetraphenylphosphonium. Uptake of 45 Ca 2+ into the vesicles was stimulated by inside‐negative ΔΨ. The rate of transport increased to a maximum at a ΔΨ of about ‐80 mV and then declined at more negative ΔΨ. When extravesicular Ca 2+ concentration was varied, uptake was maximal in the range 100–200 μM Ca 2+ . Neither dihydropyridine nor phenylalkylamine Ca 2+ channel blockers had any effect on Ca 2+ uptake but 30 μM ruthenium red was completely inhibitory with half maximal inhibition at 10–15 μM ruthenium red. Calcium transport was also inhibited by inorganic cations. Zn 2+ , Gd 3+ and Mg 2+ inhibited by a maximum of 30% while La 3+ , Nd 3+ and Mn 2+ inhibited by 70%. The inhibitory effects of La 3+ and Gd 3+ were additive. Lanthanum‐insensitive Ca 2+ five Ca 2+ transport was totally inhibited by 80 μM Gd 3+ and showed maximum activity at a ΔΨ of ‐60 mV, with less uptake at both higher and lower ΔΨ. Lanthanum and Gd 3+ also inhibited Ca 2+ uptake into protoplasts isolated from Zea roots and their individual and combined effects were similar in extent to those observed with plasma membrane vesicles. It is concluded that maize root plasma membrane contains two Ca 2+ ‐permeable channels that can be distinguished by their susceptibility to inhibition by La 3+ and Gd 3+ . Both are inhibited by ruthenium red but not by other organic Ca 2+ channel blockers.
Association of polo-like kinase with α-, β- and γ-tubulins in a stable complex (1999)

The polo-like kinase (Plk) family has been shown to have an important role in the regulation of the cell-division cycle, especially in organization of the spindle structure, in species from fungi to humans. Recent reports have demonstrated that in mammalian cells Plk is associated with components of the anaphase-promoting complex and a peptidyl-prolyl isomerase, Pin1. To characterize a putative Plk-containing complex, we fractionated mitotic cell lysates on a gel-filtration column. The Plk complex was eluted from the column at molecular sizes ranging from 669 to 2500 kDa in the presence of detergent and high concentrations of salt. Specific associations of Plk with alpha-, beta- and gamma-tubulins in both interphase and mitotic cells were shown by reciprocal immunoprecipitations and immunoblottings and were independent of the microtubule polymerization state, whereas binding assays in vitro indicated that Plk interacts with alpha- and beta-tubulins directly. In addition, mitotic Plk was able to phosphorylate associated tubulins in vitro. Finally, we show that the kinase domain of the Plk molecule is both required and sufficient for its binding to tubulins in vivo. The specific interaction between Plk and tubulins might provide a molecular basis for the physiological functions of Plk in regulating the cell cycle, particularly in establishing the normal bipolar spindle.
Kansei Engineering Analysis of Purple-clay Teapot Based on Online Comment Data (2020)

Product form has become an important communication medium between designers and consumers. Therefore, the collection and analysis of consumer evaluation of products can provide an important reference index for product form design. In this paper, purple-clay teapot was taken as an example and comments of Tmall consumers were collected through web crawler, and the product image vocabulary was extracted to analyze the needs of users. Using the research method of Kansei Engineering, the semantic space of the modeling and image of purple-clay teapot was established, and the relationship between the modeling elements and the image of purple-clay teapot was searched, which could provide valuable reference for the modeling design of purple-clay teapot.
An analytic solution for the perspective 4-point problem (2003)

The perspective n-point (PnP) problem is the problem of finding the position and orientation of a camera with respect to a scene object from n correspondence points. The authors propose an analytic solution for the perspective 4-point problem. The solution is found by replacing the four points with a pencil of three lines and by exploring the geometric constraints available with the perspective camera model. The P4P problem is cast into the problem of solving a biquadratic polynomial equation in one unknown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modeling litho-constrained design layout (2007)

This paper derived a method of modeling litho-constrained layout in design stage. The model applies directly on design layout and does not require mask-synthesis steps. Results show we can capture design-relevant litho "hot-spots" within a matter of an hour on a large full-chip data. This method proves that the hot-spot information is embedded in original design layout and can be extracted with strong signal. This method enables a designer to correct real hot-spots before tape-out. It provides a mechanism to quantify the sensitivity of layout configuration to lithography printability and to guide OPC to focus on litho-sensitive regions.
Nalmefene: Safety and Kinetics After Single and Multiple Oral Doses of a New Opioid Antagonist (1987)

The aim of these two studies was to evaluate the safety and pharmacokinetics of oral nalmefene, a new orally effective opioid antagonist. In the first study, single ascending doses of 50, 100, 200, and 300 mg of nalmefene HCl were administered in double-blind fashion to four groups of healthy men. There were six subjects in each group; four received nalmefene and two received placebo. The drug was well tolerated at all dose levels with only mild and transient side effects, such as lightheadedness, at the higher doses. Model-independent pharmacokinetic analysis of the plasma concentration-time data showed that nalmefene was rapidly absorbed and had an elimination half-life that ranged from seven to 15 hours (mean, 10.7 hr). There was a good linear relationship (r = .97) between administered dose and total area under the curve at each dose level. Only about 4% of the dose was excreted in the urine as unchanged nalmefene, whereas up to 60% was excreted as a beta-glucuronidase/sulfatase hydrolysable conjugate(s) of nalmefene. In the second study, six healthy men were initially administered a single 50-mg dose of drug, and plasma samples were obtained at selected time intervals for 48 hours. A dosing schedule of 20 mg q12h was then started and continued for seven days. Plasma samples were collected immediately before each dose and at selected times for up to 48 hours after the last dose. The drug was well tolerated by all subjects, and no clinically significant adverse effects were observed during the seven-day administration period.(ABSTRACT TRUNCATED AT 250 WORDS)
Noms et métaphores dans l’historiographie métisse (2007)

Cet article porte sur les questions relatives aux noms attribués aux personnes d’ascendance mixte et à l’histoire de ces termes, utilisés par différents groupes, autochtones ou non, à travers le temps. Les mots sont révélateurs en eux-mêmes des perceptions, variées et en perpétuel mouvement, que l’on peut avoir des personnes métisses, de leur statut et de leurs caractéristiques. Le lexique du métissage continuera à évoluer et à être l’objet de discussions, au fur et à mesure que de nouvelles perspectives historiques sur le sujet verront le jour.
Field-effect transistors based on cubic indium nitride (2014)

Although the demand for high-speed telecommunications has increased in recent years, the performance of transistors fabricated with traditional semiconductors such as silicon, gallium arsenide, and gallium nitride have reached their physical performance limits. Therefore, new materials with high carrier velocities should be sought for the fabrication of next-generation, ultra-high-speed transistors. Indium nitride (InN) has attracted much attention for this purpose because of its high electron drift velocity under a high electric field. Thick InN films have been applied to the fabrication of field-effect transistors (FETs), but the performance of the thick InN transistors was discouraging, with no clear linear-saturation output characteristics and poor on/off current ratios. Here, we report the epitaxial deposition of ultrathin cubic InN on insulating oxide yttria-stabilized zirconia substrates and the first demonstration of ultrathin-InN-based FETs. The devices exhibit high on/off ratios and low off-current densities because of the high quality top and bottom interfaces between the ultrathin cubic InN and oxide insulators. This first demonstration of FETs using a ultrathin cubic indium nitride semiconductor will thus pave the way for the development of next-generation high-speed electronics.
Expert assessment of the top platform independent cybersecurity skills for non-IT professionals (2015)

Cybersecurity threats are causing substantial financial losses for individuals, organizations, and governments. Information technology (IT) users' mistakes, due to poor cybersecurity skills, represent about 72% to 95% of cybersecurity threats to organizations. As opposed to IT professionals, computer end-users are one of the weakest links in the cybersecurity chain, due to their limited cybersecurity skills. Skills are defined as the combination of knowledge, experience, and ability to do something well. Cybersecurity skills are the skills one possess to prevent damage to IT via the Internet. However, the current measures of end-user cybersecurity skills are based on self-reported surveys. This study is the first phase of a larger research project that is aimed to develop a scenario-based iPad application to measure cybersecurity skills based on actual scenarios with hands-on tasks that the participants complete in demonstrating their skills. To design a measure that has both high validity and reliability, the first phase of the study was set forth to follow the Delphi method in seeking subject matter experts' opinion on the top platform independent cybersecurity skills for non-IT professionals. A total of 18 experts from the Florida chapter of the InfraGard, a public-private partnership between the United States Federal Bureau of Investigation (FBI)'s cyber division and private sector that focus on cybersecurity, along with subject matter experts from other federal agencies such as the United States Secret Services' (USSS) Electronic Crimes Task Force team and industry, took part in our Delphi expert panel process. The exploratory expert panel data was recorded and categorized into similar groups of comments for improvements, along with quantitative rankings. Comments were then solicited again for expert consensus, to derive the rankings of the top nine platform independent cybersecurity skills. The paper ends with some discussion on the next phase of this ongoing research along with some initial implications of the findings to practice and research.
A study of FM threshold extension techniques (1972)

The characteristics of three postdetection threshold extension techniques are evaluated with respect to the ability of such techniques to improve the performance of a phase lock loop demodulator. These techniques include impulse-noise elimination, signal correlation for the detection of impulse noise, and delta modulation signal processing. Experimental results from signal to noise ratio data and bit error rate data indicate that a 2- to 3-decibel threshold extension is readily achievable by using the various techniques. This threshold improvement is in addition to the threshold extension that is usually achieved through the use of a phase lock loop demodulator.
Alterations of the Immunologic Co-Stimulator B7 and TNFR Families Correlate with Hepatocellular Carcinoma Prognosis and Metastasis by Inactivating STAT3 (2019)

Blockade of the immunosuppressive checkpoint receptors cytotoxic T-lymphocyte-associated protein 4 (CTLA4) or programmed death 1 (PD-1) and its cognate ligand, programmed death 1 ligand (PD-L1), has altered the landscape of anti-tumor immunotherapy. B7 family and tumor necrosis factor receptor (TNFR) superfamily play a crucial role in T cell activation, tolerance, and anergy through co-stimulatory and inhibitory signal transduction. Investigating the immune molecular landscapes of the B7 and TNFR families is critical in defining the promising responsive candidates. Herein, we performed comprehensive alteration analysis of the B7 and TNFR family genes across six hepatocellular carcinoma (HCC) datasets with over 1000 patients using cBioPortal TCGA data. About 16% of patients had both B7 and TNFR gene alterations. TNFR gene amplifications were relatively more common (1.73⁻8.82%) than B7 gene amplifications (1.61⁻2.94%). Analysis of 371 sequenced samples revealed that all genes were upregulated: B7 and TNFR mRNA were upregulated in 23% of cases (86/371) and 28% of cases (105/371), respectively. Promoter methylation analysis indicated an epigenetic basis for B7 and TNFR gene regulation. The mRNA levels of B7 and TNFR genes were inversely correlated with promoter methylation status. B7-H6 expression was significantly associated with worse overall survival, and B7-H6 mRNA was increased gradually in cases with gene copy number alterations. B7-H6 overexpression was associated with aggressive clinicopathologic features and poor prognosis in HCC. Downregulation of B7-H6 in HCC cells significantly inhibited cell adhesion, proliferation, migration, and invasion. Knockdown of B7-H6 in HCC cells inhibited tumor growth and metastasis in vivo. B7-H6 promoted HCC metastasis via induction of MMP-9 expression and STAT3 activation. B7-H6 and STAT3 performed functional overlapping roles on enhancing the MMP-9 promoter activity in HCC cells. These results suggest that alterations of the immunologic co-stimulator B7 and TNFR families correlate with HCC metastasis and prognosis, and especially B7-H6 plays a critical role in promoting metastasis of HCC.
Correlation between viral load measurements and outcome in clinical trials of antiviral drugs. (1995)

Viral load monitoring, particularly when combined with other laboratory markers, can be correlated with clinical outcome. In routine clinical practice, viral load monitoring may be used to assess the need for changes in antiretroviral therapy, allowing individualized therapy. Viral load monitoring may also reduce the time needed for the clinical development of new therapeutic approaches, allowing earlier patient access to promising anti-HIV therapies.
Enzymatic Oxidation of Bilirubin (1969)

The following agents were found to oxidize bilirubin in vitro: hemoglobin and horse-radish peroxidase (both with hydrogen peroxide), cytochrome c, xanthine oxidase, and an insoluble oxidase, present in brain and other tissues. Kinetic constants were determined. The process with hemoglobin was inhibited competitively by two product molecules. The insoluble oxidase from brain was present in mitochondria. The supernatant fraction contained an inhibitor. The oxidase was inactive in the absence of salt and was unspecifically activated by a number of salts, the activity depending upon ionic strength, irrespective of which ions were present. Reaction products included biliverdin and a yellow, diazo-negative, polar pigment with the same oxidation level as bilirubin.
Genetic Studies of Drug Response and Side Effects in the STAR*D Study, Part 2 (2009)

Article Abstract ASCP Corner: Genetic Studies of Drug Response and Side Effects in the STAR*D Study, Part 2
Characterization of a DNA binding activity in DNAse I hypersensitive site 4 of the human globin locus control region (1991)

A portion of the beta-globin Locus Control Region (LCR), which included DNAse I hypersensitive site 4 (HS4), was analyzed for its interactions with nuclear extracts and its contribution to LCR activity in a functional assay. In gel retardation assays, a short fragment from HS4 formed complexes with nuclear extracts from both erythroid and nonerythroid cells, and a core protected sequence 5'GACTGGC3' was revealed by DNAse I protection and methylation interference studies. This sequence resembles the binding sites of CCAAT-family members. Purified CP-2 but not CP-1 was shown to bind this HS4 sequence in a gel shift reaction, suggesting that the HS4 binding activity shares some sequence specificity with the CCAAT-factor family. Utilizing a transient expression assay in murine erythroleukemia cells, steady-state RNA levels were measured from pairs of LCR constructs linked to distinguishable beta-globin reporter genes. A short DNA fragment from HS4 which included the binding site for this novel binding activity accounted for most of the contribution to high level expression made by the entire HS4 region.
Cytological Effects of Gestagen or Danazol on Dysplasia and Carcinoma in situ of the Cervix (1981)

子宮頸部境界病変の診断は組織学的に行われているが, 形態学だけでこれらの病変のもつ良性, 悪性などの生物学的性質のすべてを知ることはできない. そこで子宮内膜症を合併する異形成や上皮内癌において, EP合剤による偽妊娠療法やdanazol療法で内膜症を治療するとともに, 頸部病変の変化を剥離細胞診によって観察し, 組織学的異形度と各病変の生物学的性質との関係をhormone反応性の面から検討した. さらに異常上皮における鑑別診断や治療法としての可能性について考察した.その結果, 異形成や上皮内癌は外因性steroid hormoneの影響により形態的変化を示した. danazol療法では変化は少ないが, 偽妊娠療法では中等度異形成以下の病変と一部の高度異形成ではregress, 大部分の高度異形成と上皮内癌ではstable, 一部の上皮内癌ではprogressする傾向を認めた. このように偽妊娠療法を行って治療前後の変化を観察することは単に組織形態観察では知りえない各境界病変の良性, 悪性などの性質をhormone反応性に基づいて比較的短期間に判定することができ, したがって, これらの鑑別手段や軽度～中等度異形成の治療法としての可能性があると思われた。
Speech Production During Mechanical Ventilation in Tracheostomized Individuals (1994)

This investigation provides the first detailed description of speech production during mechanical ventilation. Seven adults with tracheostomies served as subjects. Recordings were made of chest wall motions, neck muscle activity, tracheal pressure, air flow at the nose and mouth, estimated blood-gas levels, and the acoustic speech signal during performance of a variety of speech tasks. Results indicated that subjects spoke for short durations that spanned all phases of the ventilator cycle, altered laryngeal opposing pressures in response to the continually changing tracheal pressure wave, and expended relatively small volumes of gas for speech production. Speech was improved by making selected ventilator adjustments. Suggestions for clinical interventions are offered.