gebhart/patrepeval huggingface dataset:
Supporting M-QAM Hierarchical Constellations in HSDPA for MBMS Transmissions (2007)

Tn this paper we consider the use of hierarchical QAM constellations (quadrature amplitude modulation) for multimedia broadcast/multicast service (MBMS) within WCDMA-based systems (wideband code division multiple access). The constellations are incorporated into HS-DSCH (high speed downlink shared channel) of UMTS (universal mobile telecommunications system). They are employed so as to increase transmission efficiency due to their ability to provide unequal error protection to different information bit streams. Nevertheless, these constellations are very sensitive to inter-symbolic interference introduced by multipath propagation, especially for large constellations, and have also high channel estimation requirements. For these reasons, we propose the use of an iterative receiver based on the turbo principle for joint detection and channel estimation. The proposed transmitter/receiver scheme is evaluated considering the presence of other parallel UMTS transmissions.
Urban Narrative: Computational Linguistic Interpretation of Large Format Public Participation for Urban Infrastructure (2020)

Urban Narrative works at the interface between public participation and participatory design to support collaboration processes for urban planning and design. It applies computational linguistics to interpret large format public consultation by identifying shared interests and desired qualities for urban infrastructure services and utilities. As a proof of concept, data was used from the Christchurch public engagement initiative called ‘Share an Idea,’ where public thoughts, ideas, and opinions were expressed about the future redevelopment of Christchurch after the 2011 earthquakes. The data set was analysed to identify shared interests and desired connections between institutional, communal, or personal infrastructures with the physical urban infrastructures in terms of buildings, public places, and utilities. The data has been visualised using chord charts from the D3 JavaScript open source library to illustrate the existence of connections between soft and hard urban infrastructures along with individual contributions or stories. Lastly, the analysis was used to create an infographic design brief that compares and contrasts qualitative information from public consultation with quantitative municipal statistical data on well-being.
Genetically Selected Cyclic‐Peptide Inhibitors of AICAR Transformylase Homodimerization (2005)

Finding the needle in a haystack need not be as troublesome as once thought. By coupling disruption of protein–protein (X–X) interactions to host-cell survival (see figure), inhibitors of ATIC (a key enzyme in the de novo purine biosynthetic pathway) were readily identified from a biosynthesized library of 107 small molecules. The activity and selectivity of nine cyclic peptides selected by this method were demonstrated in vivo and in vitro. AICAR=aminoimidazole-4-carboxamide ribonucleotide. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500417_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Organic Phosphates. I. Synthesis of 1, 2-Diol Cyclic Phosphates. (1957)

Barium salts of glycerol 1, 2-cyclic phosphate (GCP), 1, 2-propanediol cyclic phosphate (PCP), ethyleneglycol cyclic phosphate (ECP), and 2, 3-butanediol cyclic phosphate (BCP) were synthesized and Rf values of the pure products on paper chromatograms were given.
Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury (2008)

Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and cytoprotective properties, the latter via modulation of protease-activated receptor-1 (PAR-1) signaling. We generated APC variants to study the relative importance of the two functions of APC in a model of LPS-induced renal microvascular dysfunction. Compared with wild-type APC, the K193E variant exhibited impaired anticoagulant activity but retained the ability to mediate PAR-1-dependent signaling. In contrast, the L8W variant retained anticoagulant activity but lost its ability to modulate PAR-1. By administering wild-type APC or these mutants in a rat model of LPS-induced injury, we found that the PAR-1 agonism, but not the anticoagulant function of APC, reversed LPS-induced systemic hypotension. In contrast, both functions of APC played a role in reversing LPS-induced decreases in renal blood flow and volume, although the effects on PAR-1-dependent signaling were more potent. Regarding potential mechanisms for these findings, APC-mediated PAR-1 agonism suppressed LPS-induced increases in the vasoactive peptide adrenomedullin and infiltration of iNOS-positive leukocytes into renal tissue. However, the anticoagulant function of APC was responsible for suppressing LPS-induced stimulation of the proinflammatory mediators ACE-1, IL-6, and IL-18, perhaps accounting for its ability to modulate renal hemodynamics. Both variants reduced active caspase-3 and abrogated LPS-induced renal dysfunction and pathology. We conclude that although PAR-1 agonism is solely responsible for APC-mediated improvement in systemic hemodynamics, both functions of APC play distinct roles in attenuating the response to injury in the kidney.
Population-Based Molecular Prognosis of Breast Cancer by Transcriptional Profiling (2007)

This study has established a population-based approach to predicting breast cancer outcomes at the individual level exclusively based on gene expression patterns. The 28-gene recurrence signature has been validated as quantifying the probability of recurrence and metastases in patients with heterogeneous histology and disease stage.
Managing Your Competitor's Strategy (1990)

Competing on a product‐by‐product basis no longer works. Rather, take a broad view of potential competitors; then manage the overall strategies of key players.
Thin-Layer Chromatography Based on the Molecular Imprinting Technique (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThin-Layer Chromatography Based on the Molecular Imprinting TechniqueDario. Kriz, Christine Berggren. Kriz, Lars I. Andersson, and K. H. MosbachCite this: Anal. Chem. 1994, 66, 17, 2636–2639Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ac00089a008https://doi.org/10.1021/ac00089a008research-articleACS PublicationsRequest reuse permissionsArticle Views744Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ads-portal domains (2010)

An ads-portal domain refers to a Web domain that shows only advertisements, served by a third-party advertisement syndication service, in the form of ads listing. We develop a machine-learning-based classifier to identify ads-portal domains, which has 96% accuracy. We use this classifier to measure the prevalence of ads-portal domains on the Internet. Surprisingly, 28.3/25% of the (two-level) *. com /*. net web domains are ads-portal domains. Also, 41/39.8% of *. com /*. net ads-portal domains are typos of well-known domains, also known as typo-squatting domains. In addition, we use the classifier along with DNS trace files to estimate how often Internet users visit ads-portal domains. It turns out that ∼5% of the two-level *. com , *. net , *. org , *. biz and *. info web domains on the traces are ads-portal domains and ∼50% of these accessed ads-portal domains are typos. These numbers show that ads-portal domains and typo-squatting ads-portal domains are prevalent on the Internet and successful in attracting many visits. Our classifier represents a step towards better categorizing the web documents. It can also be helpful to search engines ranking algorithms, helpful in identifying web spams that redirects to ads-portal domains, and used to discourage access to typo-squatting ads-portal domains.
<i>Lactococcus lactis,</i> an Efficient Cell Factory for Recombinant Protein Production and Secretion (2007)

The use of Gram-positive bacteria for heterologous protein production proves to be a useful choice due to easy protein secretion and purification. The lactic acid bacterium Lactococcus lactis emerges as an attractive alternative to the Gram-positive model Bacillus subtilis. Here, we review recent work on the expression and secretion systems available for heterologous protein secretion in L. lactis, including promoters, signal peptides and mutant host strains known to overcome some bottlenecks of the process. Among the tools developed in our laboratory, inactivation of HtrA, the unique housekeeping protease at the cell surface, or complementation of the Sec machinery with B. subtilis SecDF accessory protein each result in the increase in heterologous protein yield. Furthermore, our lactococcal expression/secretion system, using both P(Zn)zitR, an expression cassette tightly controlled by environmental zinc, and a consensus signal peptide, SP(Exp4), allows efficient production and secretion of the staphylococcal nuclease, as evidenced by protein yields (protein amount/biomass) comparable to those obtained using NICE or P170 expression systems under similar laboratory conditions. Finally, the toolbox we are developing should contribute to enlarge the use of L. lactis as a protein cell factory.
YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes (2010)

In bacteria, ribosomes often become stalled and are released by a trans-translation process mediated by transfer-messenger RNA (tmRNA). In the absence of tmRNA, however, there is evidence that stalled ribosomes are released from non-stop mRNAs. Here, we show a novel ribosome rescue system mediated by a small basic protein, YaeJ, from Escherichia coli, which is similar in sequence and structure to the catalytic domain 3 of polypeptide chain release factor (RF). In vitro translation experiments using the E. coli-based reconstituted cell-free protein synthesis system revealed that YaeJ can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs containing rare codon clusters that extend downstream from the P-site and prevent Ala-tmRNA•SmpB from entering the empty A-site. In addition, YaeJ had no effect on translation of a normal mRNA with a stop codon. These results suggested a novel tmRNA-independent rescue system for stalled ribosomes in E. coli. YaeJ was almost exclusively found in the 70S ribosome and polysome fractions after sucrose density gradient sedimentation, but was virtually undetectable in soluble fractions. The C-terminal basic residue-rich extension was also found to be required for ribosome binding. These findings suggest that YaeJ functions as a ribosome-attached rescue device for stalled ribosomes.
Nanoporous alumina as a dielectric for microcavity plasma devices: Multilayer Al/Al2O3 structures (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation S.-J. Park, K. S. Kim, J. G. Eden; Nanoporous alumina as a dielectric for microcavity plasma devices: Multilayer Al/Al2O3 structures. Appl. Phys. Lett. 30 May 2005; 86 (22): 221501. https://doi.org/10.1063/1.1923747 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Sodium dialkyl phosphates: Surfactant properties and use in heavy duty detergents (1964)

Abstract A study of the physical and surface active properties of the sodium salts of dialkyl phosphates has been made. These compounds have been evaluated for use as surfactants in built detergents and their performance has been compared with commercial surfactants. The dialkyl hydrogen phosphates contained from 16舑26 carbon atoms per molecule and were prepared from both straight chain alcohols and commercially available branched chain alcohols. In general, the surface active properties of the branched chain compounds are better than their corresponding straight chain compounds. Good detergency performance is obtained when the number of carbon atoms per molecule is between 17 and 23. Optimum performance is obtained with the symmetrical didecyl hydrogen phosphate salts made from commercial decyl alcohol produced by the oxo‐process.
Monitoring cellular movement<i>in vivo</i>with photoconvertible fluorescence protein “Kaede” transgenic mice (2008)

Kaede is a photoconvertible fluorescence protein that changes from green to red upon exposure to violet light. The photoconversion of intracellular Kaede has no effect on cellular function. Using transgenic mice expressing the Kaede protein, we demonstrated that movement of cells with the photoconverted Kaede protein could be monitored from lymphoid organs to other tissues as well as from skin to the draining lymph node. Analysis of the kinetics of cellular movement revealed that each subset of cells in the lymph node, such as CD4(+) T, CD8(+) T, B, and dendritic cells, has a distinct migration pattern in vivo. Thus, the Kaede transgenic mouse system would be an ideal tool to monitor precise cellular movement in vivo at different stages of immune response to pathogens as well as in autoimmune diseases.
Exchanging online narratives for leisure: A legitimate learning space (2009)

Abstract: The Story Exchange section of the Sims 2 website offers Sims 2 players a forum to read and review other players' original stories which they have written while playing The Sims 2. This article draws on interview data from Sarah, a 15-year-old female involved in reading and evaluating these online stories. Analysis of Sarah's experiences in playing The Sims 2 and using the Story Exchange website suggest that players who engage with these particular online narratives determine quality indicators of the stories, without guidance or instruction from external structures or authorities. Following this point, this Story Exchange is presented not only as an avenue of leisure, pleasure and informal learning, but one that is out of alignment with structures and institutions of formal schooling. This article argues that sites such as these should be read as legitimate learning spaces.
Bacterial Degradation of Diphenylmethane, a DDT Model Substrate (1970)

A strain of Hydrogenomonas was isolated by elective culture in a solution with diphenylmethane, an analogue of DDT, as the sole carbon source. Constitutive enzymes effected the oxidation and fission of one of the benzene rings of diphenylmethane, and phenylacetic acid was found as a major degradation product. Small amounts of phenylglyoxylic and benzoic acids were also generated from diphenylmethane by the bacterium. Phenylacetic acid, which contains the second benzene ring of diphenylmethane, was metabolized by inducible enzymes.
Effective Passivation With High-Density Positive Fixed Charges for GaN MIS-HEMTs (2017)

An effective passivation with high-density positive fixed charges was demonstrated on GaN MIS-HEMTs. The positive fixed charges at the interface between passivation and AlGaN surface can reduce the surface potential and expand the quantum well under Fermi level. Besides, to satisfy charge balance, the net charge density at the AlGaN surface must equal to the 2DEG carrier density. Thus, the positive fixed charges passivation can increase the 2DEG carrier density and improve the switching performance of GaN MIS-HEMTs. In this paper, we demonstrated a high-density positive fixed charges <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$(\sim 2.71 \times 10^{13} e/cm^{-2})$ </tex-math></inline-formula> passivation using SiON for GaN MIS-HEMTs. The device with SiON passivation exhibits significant improvements in <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$I$ </tex-math></inline-formula> – <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$V$ </tex-math></inline-formula> characteristics and dynamic RON compared to the conventional SiN passivated device.
Gleaning after the European Headache Federation consensus statement on refractory chronic migraine (2014)

Correspondence/Findings We appreciated the Comment Letter from the Austrian colleagues referring to the recently published Consensus Statement on clinical definition of refractory Chronic Migraine (rCM), authored by the European Headache Federation (EHF) Expert Group [1,2]. In this Comment Letter [3] the authors present Chronische Migrane: Therapie, Therapieresistenz und Neuromodulation – Ein Konsensus-Statement, a consensus statement on CM with and without medication overuse, therapeutic options, with particular focus on patients selection for Occipital Nerve Stimulation (ONS). This article was published in a non-indexed national journal, supported by the device manufacturer [4]. We would like to underline the structural difference existing between the EHF paper and the Austrian one: the first one is finalized to the clinical definition of rCM and the proposal of criteria to be evaluated for a future inclusion of rCM as 3-digit diagnosis of CM in the next ICHD-3 (1.3.1 Refractory Chronic Migraine). The latter mostly targets to patients selection for ONS: “Diagnostic criteria for rCM and guidelines for managing targets patients with rCM and selecting candidates for invasive neuromodulation are crucial issues [4]”. In contrast, the EHF Consensus clearly states “The European Headache Federation felt to develop new consensus criteria that define rCM, particularly for the purposes of controlled clinical trials that involve experimental medication and neuromodulation independently from the non-invasive therapies or the implantable devices [1,5]”. In particular four points should be addressed:
Langasite for high-temperature bulk acoustic wave applications (2001)

Langasite (La3Ga5SiO14) and related compounds are promising candidates for high-temperature piezoelectric applications. To determine the stable operation of langasite as a high-temperature bulk acoustic wave (BAW) resonator, we characterized electrical conductivity [σel=1.56×exp(−1.07 eV/kT)S/cm] and oxygen diffusivity [DoxT=5×10−5 exp(−1.45 eV/kT)cm2/s] up to elevated temperatures. Langasite was successfully operated up to 900 °C as a BAW resonator with an average mass sensitivity of about 0.17 μg Hz−1 cm−2. This enables, in principle, high-temperature monitoring of deposition rates and thermogravimetry with high sensitivity.
Swimming Droplets (2015)

Swimming droplets are artificial microswimmers based on liquid droplets that show self-propelled motion when immersed in a second liquid. These systems are of tremendous interest as experimental models for the study of collective dynamics far from thermal equilibrium. For biological systems, such as bacterial colonies, plankton, or fish swarms, swimming droplets can provide a vital link between simulations and real life. We review the experimental systems and discuss the mechanisms of self-propulsion. Most systems are based on surfactant-stabilized droplets, the surfactant layer of which is modified in a way that leads to a steady Marangoni stress resulting in an autonomous motion of the droplet. The modification of the surfactant layer is caused either by the advection of a chemical reactant or by a solubilization process. Some types of swimming droplets possess a very simple design and long active periods, rendering them promising model systems for future studies of collective behavior.
Primary structure of rat liver D-.beta.-hydroxybutyrate dehydrogenase from cDNA and protein analyses: a short-chain alcohol dehydrogenase (1992)

The amino acid sequence of D-beta-hydroxybutyrate dehydrogenase (BDH), a phosphatidyl-choline-dependent enzyme, has been determined for the enzyme from rat liver by a combination of nucleotide sequencing of cDNA clones and amino acid sequencing of the purified protein. This represents the first report of the primary structure of this enzyme. The largest clone contained 1435 base pairs and encoded the entire amino acid sequence of mature BDH and the leader peptide of precursor BDH. Hybridization of poly(A+) rat liver mRNA revealed two bands with estimated sizes of 3.2 and 1.7 kb. A computer-based comparison of the amino acid sequence of BDH with other reported sequences reveals a homology with the superfamily of short-chain alcohol dehydrogenases, which are distinct from the classical zinc-dependent alcohol dehydrogenases. This protein family, initially discerned from Drosophila alcohol dehydrogenase and bacterial ribitol dehydrogenase, is now known to include at least 20 enzymes catalyzing oxidations of distinct substrates.
In differentiated CD4<sup>+</sup>T Cells, interleukin 4 production is cytokine-autonomous, whereas interferon γ production is cytokine-dependent (1997)

CD4+ T cells from T cell receptor transgenic mice that have been vigorously primed to be interleukin (IL)-4 producers (T(H2) cells) are capable of producing IL-4 even if restimulated in the absence of IL-4 and in the presence of IL-12. T cells vigorously primed in the absence of IL-4 (T(H1) cells) fail to produce IL-4 even if restimulated under conditions that would cause a naive T cell to produce IL-4. In contrast, interferon gamma (IFN-gamma) production is highly cytokine-regulated. T cells primed in the presence of IL-4 develop into IFN-gamma producers if IFN-gamma is included in the priming culture and if the cells are challenged in the presence of IL-12, presumably reflecting the role of IFN-gamma in inducing responsiveness to IL-12. Cells primed in the absence of IL-4 become highly responsive to IL-12 if IFN-gamma is included in the priming culture, and these cells are excellent IFN-gamma producers upon challenge; IL-12 considerably enhances their production of IFN-gamma. If cells are primed in the absence of IL-4 and IFN-gamma, they show very weak responsiveness to IL-12 as determined by STAT-4 activation. However, these cells acquire IL-12 responsiveness if cultured with IFN-gamma for a period as short as 4 hr. Thereafter, they produce large amounts of IFN-gamma upon challenge with antigen in the presence of IL-12. These results indicate that in primed CD4+ T cells, IL-4 production is largely cytokine-autonomous, whereas IFN-gamma production is highly cytokine-regulated.