gebhart/patrepeval huggingface dataset:
Characterization and Expression of a Novel Alternatively Spliced Human Angiopoietin-2 (2000)

Angiopoietin-2 (Ang2) is a naturally occurring antagonist of angiopoietin-1 (Ang1) that competes for binding to the Tie2 receptor and blocks Ang1-induced Tie2 autophosphorylation during vasculogenesis. Using the polymerase chain reaction, we isolated a cDNA encoding a novel shorter form of Ang2 from human umbilical vein endothelial cell cDNA and have designated it angiopoietin-2(443) (Ang2(443)), because it contains 443 amino acids. Part of the coiled-coil domain (amino acids 96-148) is absent in Ang2(443) because of alternative splicing of the gene. Like Ang2, recombinant Ang2(443) expressed in COS-7 cells is secreted as a glycosylated homodimeric protein. Recombinant Ang2(443) binds to the Tie2 receptor but does not induce Tie2 phosphorylation. Pre-occupation of Ang2(443) on Tie2 inhibits Ang1 or Ang2 binding and inhibits Ang1-induced phosphorylation. Expression of Ang2(443) mRNA is detectable in primary endothelial cells, several nonendothelial tumor cell lines, and primary tumor tissues. Interestingly, two cervical carcinoma cell lines express relatively moderate levels of Ang2(443) mRNA and protein. Macrophages express mainly Ang2 mRNA, but the expression of Ang2(443) mRNA is temporarily up-regulated during macrophage differentiation. These results suggest that Ang2(443) is a functional antagonist of Ang1 and could be an important regulator of angiogenesis during some tumorigenic and inflammatory processes.
Vehicular Messaging In IOT Using Epidemic Routing (2016)

Now a days there are lots of inventions done in vehicles and some may in progress, these inventions help to resolve the challenges caused by the increasing transportation issues. These modern vehicles equipped with a large amount of sensors, actuators and communication devices e.g. GPS. New vehicles have possessed powerful sensing, networking, communication and data processing capabilities and can communicate with other vehicles or exchange information with the external environments over various protocols. This can be done with the help of Vehicular communication systems; these are the networks in which vehicle and roadside units are the communicating node, with each other provide the information, such as safety warnings and traffic information. They can be effective in avoiding accidents and traffic congestion. To solve these issue sending and receiving messages is an important factor. All this things are good when the number of vehicles are less, system must be able to handle traffic spike or sudden demands caused by special events or situations such as sport games or emergencies. This is nothing but a scalability challenge which is going to overcome in this paper using routing protocol called Epidemic routing protocol.
Automatic Web Content Extraction by Combination of Learning and Grouping (2015)

Web pages consist of not only actual content, but also other elements such as branding banners, navigational elements, advertisements, copyright etc. This noisy content is typically not related to the main subjects of the webpages. Identifying the part of actual content, or clipping web pages, has many applications, such as high quality web printing, e-reading on mobile devices and data mining. Although there are many existing methods attempting to address this task, most of them can either work only on certain types of Web pages, e.g. article pages, or has to develop different models for different websites. We formulate the actual content identifying problem as a DOM tree node selection problem. We develop multiple features by utilizing the DOM tree node properties to train a machine learning model. Then candidate nodes are selected based on the learning model. Based on the observation that the actual content is usually located in a spatially continuous block, we develop a grouping technology to further filter out noisy data and pick missing data for the candidate nodes. We conduct extensive experiments on a real dataset and demonstrate our solution has high quality outputs and outperforms several baseline methods.
In Vivo and In Vitro Anaerobic Mating in <i>Candida albicans</i> (2007)

Candida albicans cells of opposite mating types are thought to conjugate during infection in mammalian hosts, but paradoxically, the mating-competent opaque state is not stable at mammalian body temperatures. We found that anaerobic conditions stabilize the opaque state at 37 degrees C, block production of farnesol, and permit in vitro mating at 37 degrees C at efficiencies of up to 84%. Aerobically, farnesol prevents mating because it kills the opaque cells necessary for mating, and as a corollary, farnesol production is turned off in opaque cells. These in vitro observations suggest that naturally anaerobic sites, such as the efficiently colonized gastrointestinal (GI) tract, could serve as niches for C. albicans mating. In a direct test of mating in the mouse GI tract, prototrophic cells were obtained from auxotrophic parent cells, confirming that mating will occur in this organ. These cells were true mating products because they were tetraploid, mononuclear, and prototrophic, and they contained the heterologous hisG marker from one of the parental strains.
Characterization of the Diversity and Temporal Stability of Bacterial Communities in Human Milk (2011)

Recent investigations have demonstrated that human milk contains a variety of bacterial genera; however, as of yet very little work has been done to characterize the full diversity of these milk bacterial communities and their relative stability over time. To more thoroughly investigate the human milk microbiome, we utilized microbial identification techniques based on pyrosequencing of the 16S ribosomal RNA gene. Specifically, we characterized the bacterial communities present in milk samples collected from 16 women at three time-points over four weeks. Results indicated that milk bacterial communities were generally complex; several genera represented greater than 5% of the relative community abundance, and the community was often, yet not always, stable over time within an individual. These results support the conclusion that human milk, which is recommended as the optimal nutrition source for almost all healthy infants, contains a collection of bacteria more diverse than previously reported. This finding begs the question as to what role this community plays in colonization of the infant gastrointestinal tract and maintaining mammary health.
Introduction to genetic programming (2007)

Article Share on Introduction to genetic programming Author: John R. Koza Stanford University, Stanford, CA Stanford University, Stanford, CAView Profile Authors Info & Claims GECCO '07: Proceedings of the 9th annual conference companion on Genetic and evolutionary computationJuly 2007Pages 3323–3365https://doi.org/10.1145/1274000.1274116Published:07 July 2007Publication History 10citation1,518DownloadsMetricsTotal Citations10Total Downloads1,518Last 12 Months24Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Publisher SiteGet Access
150  m/280  Gbps WDM/SDM FSO link based on OEO-based BLS and afocal telescopes (2016)

A 150 m/280 Gbps free-space optical (FSO) link based on an optoelectronic oscillator (OEO)-based broadband light source (BLS), afocal telescopes, and wavelength-division-multiplexing (WDM)/space-division-multiplexing (SDM) convergence is proposed. Experimental results show that the transmission distance of FSO links is significantly increased by afocal telescopes, and the transmission rate of FSO links is greatly enhanced by WDM and SDM convergence. With the aid of a low noise amplifier and clock/data recovery, good bit error rate performance and a clear eye diagram are achieved at 150 m/280 Gbps operation. This proposed 150 m/280 Gbps WDM/SDM FSO link is shown to be a prominent alternative not only because of its advancement of indoor FSO communications but also because of the advantages of optical wireless communications for a long transmission distance and high transmission rate.
CXC Chemokine Ligand 2 Induced by Receptor Activator of NF-κB Ligand Enhances Osteoclastogenesis (2010)

CXCL2 has been known to regulate immune functions mainly by chemo-attracting neutrophils. In this study, we show that CXCL2 can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. Moreover, the formation of OCs from BMMs was significantly increased on treatment with CXCL2. Conversely, the CXCL2 antagonist repertaxin and a CXCL2 neutralizing Ab potently reduced receptor activator of NF-kappaB ligand-induced osteoclastogenesis. Furthermore, CXCL2 evoked fulminant bone erosion in the in vivo mouse experiments. Finally, prominent upregulation of CXCL2 was detected in synovial fluids and sera from rheumatoid arthritis patients, suggesting a potential involvement of CXCL2-mediated osteoclastogenesis in rheumatoid arthritis-associated bone destruction. Thus, CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
Clustering relations of large databases for parallel querying (1994)

We discuss a technique for clustering relations for parallel querying in a distributed computing environment. Under the scheme, relations of relational database systems are grouped into clusters. Each cluster contains relations which are interrelated based on their primary-secondary key characteristics or commonality of their attributes/fields. Once grouped, the clusters are then distributed across a network of Sun SPARCstations, running the Parallel Virtual Machine (PVM) environment for parallel querying. The PVM system allows the total computing power of a collection of heterogeneous or homogeneous, computing processors to be harnessed for solving large problems. We have carried out parallel execution of SQL relational database queries using about 100 relations of a commercial application.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Human antimicrobial peptide histatin 5 is a cell‐ penetrating peptide targeting mitochondrial ATP synthesis in <i>Leishmania</i> (2008)

Histatin 5 (Hst5) is a human salivary antimicrobial peptide that targets fungal mitochondria. In the human parasitic protozoa Leishmania, the mitochondrial ATP production is essential, as it lacks the bioenergetic switch between glycolysis and oxidative phosphorylation described in some yeasts. On these premises, Hst5 activity was assayed on both stages of its life cycle, promastigotes and amastigotes (LC(50)=7.3 and 14.4 microM, respectively). In a further step, its lethal mechanism was studied. The main conclusions drawn were as follows: 1) Hst5 causes limited and temporary damage to the plasma membrane of the parasites, as assessed by electron microscopy, depolarization, and entrance of the vital dye SYTOX Green; 2) Hst5 translocates into the cytoplasm of Leishmania in an achiral receptor-independent manner with accumulation into the mitochondrion, as shown by confocal microscopy; and 3) Hst5 produces a bioenergetic collapse of the parasite, caused essentially by the decrease of mitochondrial ATP synthesis through inhibition of F(1)F(0)-ATPase, with subsequent fast ATP exhaustion. By using the Hst5 enantiomer, it was found that the key steps of its lethal mechanism involved no chiral recognition. Hst5 thus constitutes the first leishmanicidal peptide with a defined nonstereospecific intracellular target. The prospects of its development, by its own or as a carrier molecule for other leishmanicidal molecules, into a novel anti-Leishmania drug with a preferential subcellular accumulation are discussed.
Utility based data mining for time series analysis (2005)

In corporate data mining applications, cost-sensitive learning is firmly established for predictive classification algorithms. Conversely, data mining methods for regression and time series analysis generally disregard economic utility and apply simple accuracy measures. Methods from statistics and computational intelligence alike minimise a symmetric statistical error, such as the sum of squared errors, to model ordinary least squares predictors. However, applications in business elucidate that real forecasting problems contain non-symmetric errors. The costs arising from over- versus underprediction are dissimilar for errors of identical magnitude, requiring an ex-post correction of the prediction to derive valid decisions. To reflect this, an asymmetric cost function is developed and employed as the objective function for neural network training, deriving superior forecasts and a cost efficient decision. Experimental results for a business scenario of inventory-levels are computed using a multilayer perceptron trained with different objective functions, evaluating the performance in competition to statistical forecasting methods.
Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. (1998)

Atherogenic lipoproteins such as oxidized LDL are implicated in the pathogenesis of atherosclerosis and renal disease. Fatty acid hydroperoxides and phospholipids such as linoleyl hydroperoxide (LAox or 13-HPODE) and lysophosphatidylcholine (lyso-PC), abundant components of oxidized LDL, mediate the effects of atherogenic lipids. Oxidized LDL has been shown to induce heme oxygenase-1 (HO-1), a microsomal enzyme that is involved in heme detoxification and is a major endogenous source of carbon monoxide. HO-1 is also induced by many other stimuli that shift cellular redox. To identify the constituents and molecular mechanisms of oxidized LDL-mediated HO-1 induction, human renal epithelial cells and aortic endothelial cells were exposed to LAox and lyso-PC. Exposure to LAox (25 microM) showed an approximately 16-fold induction of HO-1 mRNA, whereas exposure to lyso-PC (25 microM) showed only an approximate 2.6-fold increase. Treatment with actinomycin-D (4 microM), a transcriptional inhibitor, as well as nuclear run-on assays, demonstrated that LAox-mediated HO-1 gene induction is dependent on de novo transcription. Cycloheximide did not affect LAox-mediated HO-1 mRNA induction, suggesting that new protein synthesis is not required for transcriptional induction. Transfection of a human HO-1 promoter-reporter gene construct showed that LAox upregulation of HO-1 occurs via mechanisms different from those of known inducers, heme and cadmium. These studies are the first demonstration that LAox induces HO-1 by transcriptional mechanisms and may have implications in the pathogenesis of cell injury in atherosclerosis and progressive renal disease.
Quantitative Analysis of Mycobacterial and Propionibacterial DNA in Lymph Nodes of Japanese and European Patients with Sarcoidosis (2002)

The cause(s) of sarcoidosis is unknown. Mycobacterium spp. are suspected in Europe and Propionibacterium spp. are suspected in Japan. The present international collaboration evaluated the possible etiological links between sarcoidosis and the suspected bacterial species. Formalin-fixed and paraffin-embedded sections of biopsy samples of lymph nodes, one from each of 108 patients with sarcoidosis and 65 patients with tuberculosis, together with 86 control samples, were collected from two institutes in Japan and three institutes in Italy, Germany, and England. Genomes of Propionibacterium acnes, Propionibacterium granulosum, Mycobacterium tuberculosis, Mycobacterium avium subsp. paratuberculosis, and Escherichia coli (as the control) were counted by quantitative real-time PCR. Either P. acnes or P. granulosum was found in all but two of the sarcoid samples. M. avium subsp. paratuberculosis was found in no sarcoid sample. M. tuberculosis was found in 0 to 9% of the sarcoid samples but in 65 to 100% of the tuberculosis samples. In sarcoid lymph nodes, the total numbers of genomes of P. acnes or P. granulosum were far more than those of M. tuberculosis. P. acnes or P. granulosum was found in 0 to 60% of the tuberculosis and control samples, but the total numbers of genomes of P. acnes or P. granulosum in such samples were less than those in sarcoid samples. Propionibacterium spp. are more likely than Mycobacteria spp. to be involved in the etiology of sarcoidosis, not only in Japanese but also in European patients with sarcoidosis.
Calcium-channel blockers and cognitive function in elderly people: results from the Canadian Study of Health and Aging. (1999)

Older people taking CCBs were significantly more likely than those using other agents to experience cognitive decline. These findings are consistent with the results of previous cross-sectional research and emphasize the need for further trials to examine the associations between CCB use, blood pressure and cognitive impairment in elderly patients.
Highly Conformable Conducting Polymer Electrodes for In Vivo Recordings (2011)

A photolithographic process was used to integrate the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) with parylene C, yielding highly conformable electrode arrays that were only four micrometers thick (shown here to conform to the midrib of a small leaf). The arrays were sufficiently self-supporting to allow in vivo evaluation in rats, yielding high-quality electrocorticography recordings.
Metal particle-free inks for printed flexible electronics (2019)

The development of metal particle-free inks is reviewed, with particular attention on their formulation, patterning and post-processing techniques.
Application of Fluorocarbon Emulsions as Components of Cosmetics and Medical Ointments (1994)

Localization and accumulation of perfluorochemicals (PFCs) in the skin and internal organs of rats after prolonged surface application of the concentrated PFC emulsion, fluorogel, have been studied by electron microscopy and gas-chromatography. The PFC concentration in skin was about 0.03-0.04 mg per 1 g of tissue. Few aggregates of emulsion particles were detected in derma. The oxygen-dependent favorable effect of fluorogel treatment of thermic burned skin and wound surface was found.
Stigmatic high throughput monochromator for soft x rays (1986)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Michael C. Hettrick and James H. Underwood, "Stigmatic high throughput monochromator for soft x rays," Appl. Opt. 25, 4228-4231 (1986) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Retrospective report on the effectiveness of a polyurethane football helmet cover on the repeated occurrence of cerebral concussions. (1999)

This report reviews the literature and unpublished data and presents survey results related to the use of a polyurethane football helmet cover. Two hundred forty-five individuals, identified by the helmet manufacturer as having purchased at least one device, were sent a survey after the 1992, 1993, and 1994 football seasons; 155 (63.3%) of the surveys were returned. The questionnaire, designed to be completed by the athlete, required a detailed history of concussions occurring both prior to and during the period the device was used. Individuals used the device as a result of having incurred at least one concussion. Rates of concussion reoccurrence while the device was worn were grouped by the number of previous concussions (1, 2, 3, or 4+) that occurred over a 4year period prior to use of the device. The rate of concussion reoccurrence was 2.4%, 7.3%, 15.8%, and 33.3%, respectively, over a 4-year period. The range appeared to reflect a parallel relationship between pre- and post-device concussion experiences: the more concussions experienced prior to adopting the device, the higher the rate of concussion reoccurrence while using the device. The natural history of repeated occurrences of concussive events may not be affected by the use of a polyurethane football helmet cover. We suggest that such a device not be routinely used prophylactically, but instead be reserved for individuals with 1 to 2 prior concussion injuries. However, at this time, we neither recommend nor discommend the device.
Principles of fractional delay filters (2002)

In numerous applications, such as communications, audio and music technology, speech coding and synthesis, antenna and transducer arrays, and time delay estimation, not only the sampling frequency but the actual sampling instants are of crucial importance. Digital fractional delay (FD) filters provide a useful building block that can be used for fine-tuning the sampling instants, i.e., implement the required bandlimited interpolation. In this paper an overview of design techniques and applications is given.
Vapor Pressure of Liquid Bismuth (1963)

The vapor pressure of liquid bismuth in the temperature range 800°—1050°K has been measured by the torsion-effusion method. The values obtained are represented by the equation: log10p (mm Hg) = 8.579— (10 108/T). A few separate Knudsen measurements have been performed in the same temperature range and the results used to calculate the molecular weight of bismuth vapor, and thus the heat of dissociation for the reaction ½ Bi2→Bi.
β‐cyclodextrin‐conjugated hyaluronan hydrogel as a potential drug sustained delivery carrier for wound healing (2015)

ABSTRACT In order to develop a potential drug sustained delivery carrier suitable for wound healing, a series of β‐cyclodextrin conjugated hyaluronan hydrogels (β‐CD‐HA) with adjustable crosslink densities were synthesized and characterized, meanwhile the delivery kinetics and mechanism of diclofenac as a model anti‐inflammatory drug from these hydrogels were investigated. By controlling the feeding molar ratio of β‐CD/HA, a β‐CD substitution degree of 4.65% was obtained by 1 H‐NMR analysis. The incorporation of β‐CD modification had little effect on the internal porous structure, water swelling ratio, and rheological property of HA hydrogel, which however were influenced by the crosslink density. Although the crosslink density had an influence on the drug loading and release profile by altering the water swelling property, the interaction between β‐CD and drug was the primary factor for the high loading capacity and long‐term sustained delivery of diclofenac. The semiempirical equation fit showed that the release of diclofenac from HA‐based hydrogels followed a pseudo‐Fickian diffusion mechanism. By the aid of β‐CD and controlled crosslink density, a β‐CD‐HA hydrogel with a diclofenac sustained delivery period of over 28 days and desirable physicochemical properties was achieved, which will be a promising drug sustained delivery carrier for wound healing. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43072.