gebhart/patrepeval huggingface dataset:
A Unified Approach to Adjusting Association Tests for Population Admixture with Arbitrary Pedigree Structure and Arbitrary Missing Marker Information (2000)

A general approach to family-based examinations of association between marker alleles and traits is proposed. The approach is based on computing p values by comparing test statistics for association to their conditional distributions given the minimal sufficient statistic under the null hypothesis for the genetic model, sampling plan and population admixture. The approach can be applied with any test statistic, so any kind of phenotype and multi-allelic markers may be examined, and covariates may be included in analyses. By virtue of the conditioning, the approach results in correct type I error probabilities regardless of population admixture, the true genetic model and the sampling strategy. An algorithm for computing the conditional distributions is described, and the results of the algorithm for configurations of nuclear families are presented. The algorithm is applicable with all pedigree structures and all patterns of missing marker allele information.
Screening of freeze-dried protective agents for the formulation of biocontrol strains, Bacillus cereus AR156, Burkholderia vietnamiensis B418 and Pantoea agglomerans 2Re40 (2011)

This study showed that freeze-drying could be used to stabilize cells of these three biocontrol strains. Further studies should focus on the scale-up possibilities and formulation development.
Mitigation of fast ions from laser-produced Sn plasma for an extreme ultraviolet lithography source (2006)

The authors present evidence of the reduction of fast ion energy from laser-produced Sn plasma by introducing a low energy prepulse. The energy of Sn ions was reduced from more than 5keV to less than 150eV nearly without loss of the in-band conversion from laser to 13.5nm extreme ultraviolet (EUV) emission as compared with that of a single pulse. The reason may come from the interaction of the main pulse with preplasma instead of the full density solid surface. This makes it possible to use the full density Sn target in the practical EUV lithography source.
Impact of Fluorination and Side-Chain Length on Poly(methylpropenoxyalkylsiloxane) and Poly(alkyl methacrylate) Solubility in Supercritical Carbon Dioxide (2002)

ADVERTISEMENT RETURN TO ISSUECommunication to the...Communication to the EditorNEXTImpact of Fluorination and Side-Chain Length on Poly(methylpropenoxyalkylsiloxane) and Poly(alkyl methacrylate) Solubility in Supercritical Carbon DioxideMark A. McHugh, Alberto Garach-Domech, Il-Hyun Park, Dan Li, Eugen Barbu, Paul Graham, and John TsibouklisView Author Information Department of Chemical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284; Department of Polymer Science & Engineering, Kumoh National University of Technology, Kyungbuk, Korea; Chemistry Department, University of Ploiesti, Bd. Bucuresti 39, RO-2000, Ploiesti, Romania; and School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, U.K. Cite this: Macromolecules 2002, 35, 17, 6479–6482Publication Date (Web):July 18, 2002Publication History Received14 December 2001Revised24 June 2002Published online18 July 2002Published inissue 1 August 2002https://pubs.acs.org/doi/10.1021/ma012169ihttps://doi.org/10.1021/ma012169irapid-communicationACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views412Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Organic compounds,Polymers,Siloxanes,Solubility Get e-Alerts
Mechanism of Gases Transfer through Polymer Membranes and Membrane Module Calculation Model to Separate Gases (2012)

Abstract The given work considers gas separation process using non-porous polymer membranes. Here membrane separation of gas mixtures is based on employment of permeation-selective membranes and gases transfer mechanism through non-porous membranes has been considered. Approximate method of membrane module calculation to separate gases considering binary gas mixture, which consists of two components, has been suggested as well. As a result of the suggested methods membrane surface necessary to separate gas mixture has been found.
Strategies for multi-rate recording for a consumer digital VCR (1994)

This paper explores strategies for varying data rates while maintaining tape data density in low-cost digital VCRs by using sequential head-switching techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Addition Polymerization of Aliphatic Dlthlols with Diene Monomers (1991)

Abstract The photoinitiated free radical polymerization of triethylene-glycoldithiol and hydrochinonebisallylether or ethyleneglycoldivi-nylether leads to poly (the ethers) having anti-Markovnikov structure M n: 14,000, 12,000 (VPO), respectively. The chain propagation is limited by a cyclic product (nearly 4%). Telechelics may be obtained by the use of nonequivalent molar ratio of the thioVenemonomers. They are useful in preparation of block copol-ymers and networks, respectively. By means of ESR-spectroscopic investigations, it is shown that in dithiole/diene mixtures, which are free of daylight and oxygen, radicals are formed spontaneously. Using the spin-trapping technique, the existence of sulfur and carbon radicals could be proved unambiguously.
Diagnostic Techniques in Hematological Malignancies (2010)

The diagnosis and monitoring of hematological malignancies is complex and requires a systematic approach. Morphology, cell phenotyping, cytogenetics and molecular genetics are essential, and the results must be integrated. Diagnostic Techniques in Hematological Malignancies details the principles and applications of each of these test types in the diagnosis of hematological malignancies in blood and bone marrow. The first section describes the test modalities – including methodological principles, data interpretation and limitations – and is illustrated by clinical examples. The second section focuses on the clinical entities, detailing the most appropriate tests for diagnosis, staging and monitoring of different hematological malignancies and includes test utilization to identify prognostic markers and potential therapeutic targets. With contributions from multiple international experts, this illustrated book is an essential resource for qualified and trainee hematologists, oncologists, and pathologists. It's a practical and useful guide, providing a rational and structured approach to the laboratory assessment of hematological malignancies.
Function, Structure, and Evolution of the RubisCO-Like Proteins and Their RubisCO Homologs (2007)

About 30 years have now passed since it was discovered that microbes synthesize RubisCO molecules that differ from the typical plant paradigm. RubisCOs of forms I, II, and III catalyze CO(2) fixation reactions, albeit for potentially different physiological purposes, while the RubisCO-like protein (RLP) (form IV RubisCO) has evolved, thus far at least, to catalyze reactions that are important for sulfur metabolism. RubisCO is the major global CO(2) fixation catalyst, and RLP is a somewhat related protein, exemplified by the fact that some of the latter proteins, along with RubisCO, catalyze similar enolization reactions as a part of their respective catalytic mechanisms. RLP in some organisms catalyzes a key reaction of a methionine salvage pathway, while in green sulfur bacteria, RLP plays a role in oxidative thiosulfate metabolism. In many organisms, the function of RLP is unknown. Indeed, there now appear to be at least six different clades of RLP molecules found in nature. Consideration of the many RubisCO (forms I, II, and III) and RLP (form IV) sequences in the database has subsequently led to a coherent picture of how these proteins may have evolved, with a form III RubisCO arising from the Methanomicrobia as the most likely ultimate source of all RubisCO and RLP lineages. In addition, structure-function analyses of RLP and RubisCO have provided information as to how the active sites of these proteins have evolved for their specific functions.
IMGT, the International ImMunoGeneTics Information System <sup>®</sup> , http://imgt.cines.fr (2003)

IMGT, the international ImMunoGeneTics information system® (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complexes (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989 by LIGM at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, and 2D and 3D structures. IMGT includes five databases (IMGT/LIGM-DB, IMGT/3Dstructure-DB, IMGT/MHC-DB, IMGT/PRIMER-DB, IMGT/GENE-DB) Web resources (‘IMGT Marie-Paule page’) and interactive tools (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/LocusView, IMGT/GeneView, IMGT/GeneSearch, IMGT/StructureQuery). IMGT data are expertly annotated according to the rules of the IMGT Scientific chart based on IMGT-ONTOLOGY. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in physiological normal and pathological situations. IMGT has important applications in medical research (autoimmune diseases, AIDS, leukaemias, lymphomas, myelomas), biotechnology related to antibody engineering (phage displays, combinatorial libraries) and therapeutic approaches (graft, immunotherapy). IMGT is freely available at http://imgt.cines.fr.
Synergistic Enhancement of Nuclear Receptor Function by p160 Coactivators and Two Coactivators with Protein Methyltransferase Activities (2001)

Nuclear receptors (NRs) activate gene transcription by binding to specific enhancer elements and recruiting coactivators of the p160 family to promoters of target genes. The p160 coactivators in turn enhance transcription by recruiting secondary coactivators, including histone acetyltransferases such as CREB-binding protein (CBP) and p300/CBP-associated factor (p/CAF), as well as the recently identified protein methyltransferase, coactivator-associated arginine methyltransferase 1 (CARM1). In the current study, protein arginine methyltransferase 1 (PRMT1), another arginine-specific protein methyltransferase that shares a region of high homology with CARM1, was also found to act as a coactivator for NRs. PRMT1, like CARM1, bound to the C-terminal AD2 activation domain of p160 coactivators and thereby enhanced the activity of NRs in transient transfection assays. The shape of the graphs of reporter gene activity versus the amounts of CARM1 or PRMT1 expression vector indicated a cooperative relationship between coactivator concentration and activity. Moreover, CARM1 and PRMT1 acted in a synergistic manner to enhance reporter gene activation by both hormone-dependent and orphan NRs. The synergy was most evident at low levels of transfected NR expression vectors, where activation of reporter genes was almost completely dependent on the presence of NR and all three exogenously supplied coactivators, i.e. GRIP1, CARM1, and PRMT1. In contrast, with the higher levels of NR expression vectors typically used in transient transfection assays, NR activity was much less dependent on the combination of coactivators, suggesting that target gene activation occurs by different mechanisms at high versus low cellular concentrations of NR. Because multiple coactivators are presumably required to mediate transcriptional activation of native genes in vivo, the low-NR conditions may provide a more physiologically relevant assay for coactivator function.
Evaluation of bitter apple (Citrullus colocynthis (L.) Schrad) as potential rootstock for watermelon (2017)

Selecting appropriate rootstocks in grafting is an important aspect to increase yield and fruit quality of vegetables. Interspecific hybrids and gourd are the most frequently used rootstocks for watermelon (Citrullus lanatus var. (Thunb.) Matsum. & Nakai) grafting. However, other Citrullus species such as bitter apple (Citrullus colocynthis (L.) Schrad) have not been completely exploited and can be a source of interesting traits. The present study aimed to evaluate bitter apple as potential rootstock for watermelon (cv. Crimson Sweet) in comparison to the commercial rootstock Shintosa (Cucurbita maxima Duch. Cucurbita moschata Duch.), and non-grafted plants. An experimental design of Randomized Complete Blocks was applied with treatments replicated three times. Grafted and non-grafted watermelon plants were compared in terms of yield, yield components, morphometric and textural characteristics, sweetness, acidity and mineral composition. The effect of Shintosa rootstock on total yield and mean fruit weight resulted in 20.2% and 14.0% increase over the non-grafted and Crimson Sweet/bitter apple combination, respectively. Flesh firmness and fruit mineral composition (Ca, P and Zn) increased by grafting Crimson Sweet on Shintosa over the other grafting combinations. The most valued fruit quality traits for consumer satisfaction: fruit dry matter (DM) and total soluble solids (TSS) were significantly higher with bitter apple rootstock. The fruit DM and TSS contents recorded for Crimson Sweet grafted on bitter apple were significantly higher than those grafted on Shintosa by 11.7% and 8.4%, respectively. Though grafting watermelon on bitter apple slightly decreased yield characteristics than Shintosa, on the other hand it improved flavor compounds with no serious detrimental effects on other quality attributes, thus it could be proposed as potential germplasm for watermelon rootstock breeding.
Synthesis of 2,5-dihydroxy-2,5-dihydrofurans by anodic oxidation of furans (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2,5-dihydroxy-2,5-dihydrofurans by anodic oxidation of furansJan Froborg, Goran Magnusson, and Svante ThorenCite this: J. Org. Chem. 1975, 40, 1, 122–123Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/jo00889a031https://doi.org/10.1021/jo00889a031research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A self-recovery scheme for service function chaining (2015)

Service function chaining provides a new service deployment model that delivers the traffic along the predefined logical paths of service functions with no regard of network topologies or transport mechanisms. The traffic path of service functions needs to be recovered at failure of the service functions but it may incur a signaling delay among control-plane and data-plane components. In order to shorten the delay of the path recovery at the failure, we propose a self-recovery scheme that temporally recovers the traffic path from the failure by shifting the responsibility of a service function in failure to another service function with data-plane signaling.
Mechanisms of otoconia and otolith development (2014)

This review will summarize recent findings as well as compare otoconia and otolith development. It will provide an updated brief review of otoconial proteins along with an overview of the cells and cellular processes involved. While continued efforts are needed to thoroughly understand the molecular mechanisms underlying otoconia and otolith development, it is clear that the process involves a series of temporally and spatially specific events that are tightly coordinated by numerous proteins. Such knowledge will serve as the foundation to uncover the molecular causes of human otoconia-related disorders.
Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway (2017)

HDAC6 expression is altered during lung fibrogenesis. Tubastatin represses TGF-β1-induced collagen expression, by diminishing Akt phosphorylation and regulating downstream targets such as HIF-1α-VEGF axis and autophagy. Tubastatin-treated WT mice are protected against bleomycin-induced fibrosis, but HDAC6 KO mice are not. Our data suggest that Tubastatin ameliorates pulmonary fibrosis, by targeting the TGFβ-PI3K-Akt pathway, likely via an HDAC6-independent mechanism.
Relationship between the Quantity of Progesterone Receptor and the Antagonism of Estrogen-Induced Uterotropic Response* (1979)

The ability of the uterus to respond to progesterone was examined as a function of cytosol progesterone receptor levels. The response was assessed by measuring the capacity of progesterone to antagonize estradiol-induced uterine fluid accumulation in uteri containing either high or low levels of progesterone receptor. High receptor levels (4-12 pmol/uterus) were induced by estradiol treatment (1.0 μg/rat/day for 2 days) in ovariectomized rats. Low levels (≤2 pmol/uterus) were obtained by injecting estrogen-primed rats with 0.5 mg progesterone and waiting 24 h before subsequent treatment. Progesterone (0.5 mg) was very effective in inhibiting estradiol-induced uterine fluid accumulation in uteri with high levels of receptor, whereas the same dose of progesterone was without effect in uteri with low levels of receptor. These data demonstrate that the level of cytosol progesterone receptors is correlated with the ability of the uterus to respond to progesterone. The reduction in progesterone receptors observed 24 h after an injection of 0.5 mg progesterone was not due to a shift in ligand specificity, a change in dissociation constant, or increased in vitro Ca++-dependent proteolysis of receptor. Instead, we conclude that the reduction is due to an actual decrease in the number of progesterone receptor sites. This receptor reduction after progesterone treatment is preceded by complete replenishment of uterine cytosol receptor within 12 h of injection in the adrenalectomized-ovariectomized rat. Therefore, the mechanism by which cytosol progesterone receptors are decreased at 24 h must operate between 12–24 h. In conclusion, the reduction of progesterone receptors in uterine cytosol 24 h after progesterone treatment results from an actual decrease in receptor numbers which occurs during the period 12–24 h after injection. This loss of receptors reduces the ability of the uterus to respond to subsequent progesterone administration.
Polyelectrolyte multilayer assembly bearing ketoprofen for transdermal delivery (2009)

Abstract A novel microencapsulation technology based on layer-by-layer assembly has been extensively studied and used for controlled delivery of drug microcrystal having poor aqueous solubility and low bioavailability. A non-steroidal anti-inflammatory drug ketoprofen (KF)was selected for encapsulation using biodegradable and biocompatible polyions and synergistically the fabricated system was embedded in gel matrix for topical application. Topical application of the drugs at the pathological sites offer potential advantages of delivering the drug directly to the site of action and thus producing high tissue concentrations of the drug.
Experimental realization of chaos control by thresholding (2003)

We report the experimental verification of thresholding as a versatile tool for efficient and flexible chaos control. The strategy here simply involves monitoring a single state variable and resetting it when it exceeds a threshold. We demonstrate the success of the technique in rapidly controlling different chaotic electrical circuits, including a hyperchaotic circuit, onto stable fixed points and limit cycles of different periods, by thresholding just one variable. The simplicity of this controller entailing no run-time computation, and the ease and rapidity of switching between different targets it offers, suggests a potent tool for chaos based applications.
Asymptotic sampling distribution of inverse coefficient-of-variation and its applications (1994)

This paper develops the asymptotic sampling distribution of the inverse of the coefficient of variation (InvCV). This distribution is used for making statistical inference about the population CV (coefficient of variation) or InvCV without making an assumption about the population distribution. It applies to making inferences (point and interval estimation, and hypothesis-testing) about the shape parameter of some popular lifetime distributions like the Gamma, Weibull, and log-normal, when the scale parameter is unknown. The test procedure is used to test exponentiality against a Gamma or a Weibull alternative. The results are compared with those in the literature.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Position control of a two-link satellite tracker manipulator using optical flow (2009)

In this work, the objective was to implement visual servo control based on the optical flow method to move a robotic manipulator end-effector in order to provide on-orbit servicing of space satellites. The visual servo system is made up of a single monocular camera mounted on the end-effector, and is to be used by the robot for autonomous location of the satellite. Firstly, using the pyramidal Lucas-Kanade method, optical flow field is extracted from image sequences captured by the camera. The pixel coordinates corresponding to the targeted location in the image frame is marked and registered into the system. The marked pixel coordinates is then converted into the robotic manipulator workspace coordinates. These coordinates are then used to compute the manipulator joint angles. Using the camera to send visual feedback information in closed loop control, the task is repeated until the target is reached.