gebhart/patrepeval huggingface dataset:
Circulating transcripts in maternal blood reflect a molecular signature of early-onset preeclampsia (2020)

Circulating RNA (C-RNA) is continually released into the bloodstream from tissues throughout the body, offering an opportunity to noninvasively monitor all aspects of pregnancy health from conception to birth. We asked whether C-RNA analysis could robustly detect aberrations in patients diagnosed with preeclampsia (PE), a prevalent and potentially fatal pregnancy complication. As an initial examination, we sequenced the circulating transcriptome from 40 pregnancies at the time of severe, early-onset PE diagnosis and 73 gestational age-matched controls. Differential expression analysis identified 30 transcripts with gene ontology annotations and tissue expression patterns consistent with the placental dysfunction, impaired fetal development, and maternal immune and cardiovascular system dysregulation characteristic of PE. Furthermore, machine learning identified combinations of 49 C-RNA transcripts that classified an independent cohort of patients (early-onset PE, <i>n</i> = 12; control, <i>n</i> = 12) with 85 to 89% accuracy. C-RNA may thus hold promise for improving the diagnosis and identification of at-risk pregnancies.
EVIDENCE THAT LS-2616 (LINOMIDE) CAUSES ACUTE REJECTION OF RAT ALLOGRAFTS PROTECTED BY CYCLOSPORINE BUT NOT OF LONG-TERM SURVIVING ALLOGRAFTS (1991)

The immunomodulator LS-2616 (Linomide) induces rejection of cyclosporine-protected rat cardiac allografts. The aim of this study was to characterize this rejection in the presence of CsA and to test LS-2616 in other models of permanent graft acceptance in the rat. PVG rat hearts were transplanted heterotopically to Wistar/Kyoto (Wi/Ky) rat recipients on day 0. The recipients were treated orally on days 0-9 with CsA (10-40 mg/kg) and/or with LS-2616 (2.5-160 mg/kg) starting at different times (day -7 -+5) until the day of complete rejection. The addition of LS-2616 (day -1--stop) to CsA (10 mg/kg) resulted in a dose-dependent antagonism of the immunosuppressive effect of CsA with daily doses of 2.5-160 mg/kg. Furthermore, the results were similar, irrespective of whether LS-2616 treatment (160 mg/kg) was started on day -7, -1, +1, +3, or +5. LS-2616 (160 mg/kg) pretreatment of the recipient for 7 days before transplantation was considerably less effective. CsA (20 mg/kg) for 14 days after a PVG to DA transplantation resulted in permanent graft survival. This was not abrogated by LS-2616. Neither was rejection induced in long-term surviving grafts of RT1.C incompatible Lewis recipients. Our data suggest that LS-2616 activates already stimulated and sensitized T cells that are otherwise controlled by CsA.
ACTH Receptors in the Adrenal: Specific Binding of ACTH- <sup>125</sup> I and Its Relation to Adenyl Cyclase (1970)

Pure monoiodo ACTH-(125)I was prepared that was biologically active and free of unlabeled ACTH. Extracts of adrenal cortex that contained ACTH-sensitive adenyl cyclase, bound ACTH-(125)I; extracts that lacked the ACTH-sensitive cyclase did not bind ACTH-(125)I. Unlabeled ACTH inhibited the binding of ACTH-(125)I. Five ACTH derivatives which varied widely in biological activity were tested. All inhibited the binding of ACTH-(125)I in direct proportion to their biological activity. Albumin, insulin, and four unrelated iodinated hormones were inert. The addition of excess hormone or acetic acid produced rapid dissociation of bound ACTH-(125)I. This study demonstrates directly the binding of ACTH to its biologically significant site.
Capacitive pressure sensing with suspended graphene–polymer heterostructure membranes (2017)

We describe the fabrication and characterisation of a capacitive pressure sensor formed by an ultra-thin graphene-polymer heterostructure membrane spanning a large array of micro-cavities each up to 30 μm in diameter with 100% yield. Sensors covering an area of just 1 mm<sup>2</sup> show reproducible pressure transduction under static and dynamic loading up to pressures of 250 kPa. The measured capacitance change in response to pressure is in good agreement with calculations. Further, we demonstrate high-sensitivity pressure sensors by applying a novel strained membrane transfer and optimising the sensor architecture. This method enables suspended structures with less than 50 nm of air dielectric gap, giving a pressure sensitivity of 123 aF Pa<sup>-1</sup> mm<sup>-2</sup> over a pressure range of 0 to 100 kPa.
Fault-Tolerant Microprocessor-Based Systems (1984)

How do computers go wrong and what can we do about it? This tutorial outlines the causes of faults and the basic techniques for dealing with them.
Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical Reality (2006)

The identification of activated oncogenes, such as the bcl-2, in several types of cancer has made it possible to consider such genes as targets for antitumor therapy. Bcl-2 is an anti-apoptotic protein, whose overexpression is associated with chemotherapy resistant cancer, aggressive clinical course and poor survival. The development of novel targeted gene-silencing strategies, such as those based on the use of antisense oligonucleotides, represents a renewed hope in the treatment of cancer. Within this scope, this review covers the main pre-clinical aspects and the most recent clinical data obtained with Oblimersen sodium (Genta Inc.). Oblimersen is a 18-mer phosphorothioate antisense oligonucleotide designed to bind to the first six codons of the human bcl-2 mRNA. Phase I/II trials indicate that infusion of Oblimersen provides biologically relevant plasma levels that lead to downregulation of target Bcl-2 protein. Moreover, the use of Oblimersen in combination with chemotherapy in a variety of cancers has shown promising response rates with good tolerability. Randomized phase III trials are currently underway to evaluate whether the combined use of Oblimersen with standard treatment is superior to standard treatment alone in chronic lymphocytic leukaemia, malignant melanoma and multiple myeloma. Overall, the enhanced efficacy of anticancer treatments of this bcl-2-targeted antisense therapy represents a promising new apoptosis-modulating strategy.
PRELIMINARY MISSION RESULTS AND PROJECT EVALUATION OF THE DELFI-C 3 NANO-SATELLITE (2008)

This paper discusses preliminary mission results of Delfi-C 3 up till the early operations phase. The first section will discuss the design philosophy of Delfi -C 3 . To reduce operational risks, Delfi-C 3 followed the KISS principle and is designed to be Single-Point-of-Fai lurefree. A balance is made between adoption of professional space engineering customs and standard s on one hand and the limitations of small satellites , financial budgets and limited human resources on th e other hand. The second section of the paper discuss es the project planning and management of Delfi-C 3 . Addressed are reasonable timelines for the development of a nano-satellite, how to deal with a launch slip and the occasional conflicts between the interest of th e students and the interest of the project. The third section of the paper will present the results of the early operations of Delfi-C 3 . Discussed are the performance of the payloads, the bus and the ground network of the satellite. Finally, an early statement of the missi on success will be given.
Geometric and Electronic Structures of Nickel(II) Complexes of Redox Noninnocent Tetradentate Phenylenediamine Ligands (2015)

Five tetradentate ligands based on the N,N'-bis(2-amino-3,5-di-tert-butylphenyl)-o-phenylenediamine backbone were prepared, with different substituents at positions 4 and 5 (CH3 (3a), p-CH3O-C6H4 (3b), H (3c), Cl (3d), F (3e)). Their reaction with a nickel(II) salt in air affords the neutral species 4(a-e), which were isolated as single crystals. 4(a-e) feature two antiferromagnetically exchange-coupled diiminosemiquinonate moieties, both located on peripheral rings, and a diamidobenzene bridging unit. Oxidation of 4(a-e) with 1 equiv of AgSbF6 yields the cations 4(a-e)(+), which harbor a single diiminosemiquinonate radical. Significant structural differences were observed within the series. 4b(+) is mononuclear and contains a localized diiminosemiquinonate moiety. In contrast, 4c(+) is a dimer wherein the diiminosemiquinonate radical is rather delocalized over both peripheral rings. 4d(+) represents an intermediate case where the complex is mononuclear, but the radical is fully delocalized. Oxidation of 4(a-e) with 2 equiv of AgSbF6 produces the corresponding mononuclear dications. X-ray diffraction data on 4(b-d)(2+) reveals that the bridging ring retains its diamidobenzene character, whereas both peripheral rings have been oxidized into diiminobenzoquinone moieties. All the complexes were characterized by electrochemistry, EPR, and UV-vis-NIR spectroscopy. Remarkably, the electronic structures of the complexes differ from those reported by Wieghardt et al. for copper and zinc complexes of a related ligand involving a mixed N2O2 donor set (J. Am. Chem. Soc. 1999, 121, 9599). The easier oxidation of phenylenediamine moieties in comparison to aminophenols is proposed to account for the difference.
Structural and electrical properties of transparent conductor SrVO3 thin films grown using radio frequency sputtering deposition (2019)

Transparent conductor SrVO3 thin films were grown on (LaAlO3)0.3(Sr2AlTaO6)0.7 (LSAT), SiO2/Si, LaAlO3, and sapphire substrates using RF magnetron sputtering deposition with commercial SrVO3 targets at temperatures as low as 400 °C. Considering the complex phases of SrVO3 material systems, the growth temperature and sputtering gases were optimized and precisely controlled to yield a transparent and conductive SrVO3 phase. The authors used a mixed gas atmosphere of Ar and H2 during growth for reduction. Structural and morphological properties of all SrVO3 films were investigated using x-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), and scanning electron microscopy. XRD and HRTEM showed a highly crystalline cubic phase of SrVO3 films. In addition, HRTEM showed that a superstructure along the [100] direction could be formed due to Jahn-Teller distortion in the cubic phase of SrVO3 films. The authors obtained a resistivity of 0.2 × 10−3 Ω cm, mobility of 1.82 cm2/(V s), and carrier concentration of 1.57 × 1022 cm−3 for SrVO3/LSAT films. Optical transmittance was measured as 88% at a photon wavelength of 633 nm for 39-nm-thick SrVO3 films. Using x-ray photoemission spectroscopy (XPS) and its depth profile analysis, the authors investigated chemical compositions and binding energies of Sr, V, and O atoms in SrVO3 films, and their depth profiles. The authors found a correlation between the resistivities and XPS binding energy spectra for SrVO3 films as functions of film thickness and substrates.
Elder Abuse: The Role of the Orthopaedic Surgeon in Diagnosis and Management (2002)

Increased awareness of elder abuse has led to the recognition that mistreatment of individuals over the age of 65 years is a widespread public health problem. It is estimated that the prevalence of elder abuse is 32 cases per 1,000 persons and is increasing with the growing elderly population. Elder abuse is suspected to be a major source of morbidity and mortality, representing a high economic burden to society. The diagnosis of elder abuse is seldom straightforward due to social issues, cognitive impairment, and comorbid conditions, and requires careful correlation of historical and clinical findings. Comprehensive evaluation, including a detailed history, systematic physical examination, and appropriate laboratory and radiographic assessment, is essential. The orthopaedic surgeon consulted to evaluate an elderly individual with musculoskeletal injuries must be cognizant of the potential for elder abuse, especially when circumstances are suspect. The role of the orthopaedic surgeon is often fundamental to establishing whether musculoskeletal injuries are consistent with the stated mechanism of injury. Due to the variety of presentations, there are no fracture patterns considered pathognomonic of elder abuse. Rather, the nature and pattern of injury must be viewed in the context of the general health and psychosocial environment of the patient to determine whether abuse has occurred. Once the diagnosis of elder abuse has been made, a comprehensive, multidisciplinary long-term care plan must be formulated to ensure patient safety while respecting the autonomy of a competent individual. Physicians have an ethical and legal responsibility to protect patients from suspected abuse, and most states mandate reporting by health-care personnel.
Hierarchical block-motion estimation using linear model-based postprocessing (1993)

A two-hierarchy block-motion estimation method is proposed which uses a postprocessor based on a linear model of the blockmotion vector field. Postprocessing in each hierarchy uses the linear model to correct false motion vectors estimated by blockmatching. By depending on a weighting parameter and window size for the correction, the global or local motion is effectively generated at each hierarchy.
New Zeiss interferometer (1991)

A new Zeiss interferometer, the Direct 100, is described. This interferometer contains important improvements that are especially applicable to measurements in the presence of vibrations, measurements requiring the highest spatial resolution, integration of testing into manufacturing, use of interferometry for optimum assembly of complex systems, high-precision measurements in air with sub-nm accuracies, absolute calibration of residual errors, testing of aspheres with partial compensation and electronic hologram, measurement of fast processes, and temporally resolved measurements. The measurement and evaluation principle of the Direct 100 are described along with its optics, mechanics, and electronics.
A theoretical analysis of etched grating couplers for integrated optics (1973)

Grating couplers provide an attractive method for the excitation of optical thin-film waveguides. We present here a perturbation analysis of etched or deposited grating couplers based upon both the transmission line and the Green's Function approaches, which predict the coupling efficiency, the output radiation beamwidth, the angular dependence of excitation, and the intensities of the other orders of the diffracted beams as functions of the grating periodicity, grating groove depth, and excitation direction. It is found that the maximum excitation efficiency is 81 percent, that high efficiency can be achieved by excitation from the substrate, and that higher efficiency is obtained when the radiation leakage to the side orders is minimized.
Targeting CXCR1/2 Significantly Reduces Breast Cancer Stem Cell Activity and Increases the Efficacy of Inhibiting HER2 via HER2-Dependent and -Independent Mechanisms (2012)

These studies establish a role for IL-8 in the regulation of patient-derived breast CSC activity and show that IL-8/CXCR1/2 signaling is partly mediated via a novel SRC and EGFR/HER2-dependent pathway. Combining CXCR1/2 inhibitors with current HER2-targeted therapies has potential as an effective therapeutic strategy to reduce CSC activity in breast cancer and improve the survival of HER2-positive patients.
ChemInform Abstract: Preparation of (.+‐.)‐1‐Allyl‐4‐deoxy Mannose Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antiallodynia and antihyperalgesia effects of ceftriaxone in treatment of chronic neuropathic pain in rats (2012)

The results suggest that ceftriaxone as a modulator of glutamate uptake could provide beneficial effects in the treatment of chronic neuropathic pain, especially allodynia that is less sensitive to the most available drugs.
Phase staggering control of a series-resonant dc-dc converter with paralleled power modules (1987)

A method of decreasing the ripple on the output voltage of high power ac-dc or dc-dc series resonant converters without increasing the internal converter frequency or the capacity of the energy storage elements is discussed. This improvement is accomplished by subdividing the converter into two or more series resonant power modules. The power modules are operated with a constant relative phase shift (phase-staggering control). The method of eliminating the harmonic components in the input and output currents of the conversion system, without increasing the internal pulse frequency, is justified by Fourier analysis of the current waveforms. The frequency spectra of the source and output waveforms for the continuous and discontinuous resonant current mode are shifted to higher frequency ranges as computations show for both one single module and paralleled modules. Inadequacies in the phase-staggering control method applied to series-resonant converters are indicated in relation to the dominant harmonic component, in particular for two modules. The presentation is supported by experimentally acquired waveforms. The control method decreases the rms current through the input and output capacitors of the converter and the losses in the indicated components, which is especially advantageous for low-voltage, high-current applications. High-frequency current components to the source and to the load are reduced, resulting in smaller input and output filters. The resolution of the control of the flow of energy from the source to the load is improved, resulting in a faster system response.
Planarized self-aligned double-polysilicon bipolar technology (2003)

The combination of self-aligned double-polysilicon bipolar technology with the trench isolation technique and planarized field oxide and polysilicon regions results in a high-performance bipolar VLSI process, planarized at all mask levels. The planarization approach simplifies photolithography. It also eliminates deformation and discontinuities of polysilicon lines over severe topography and problems with polysilicon residue after RIE steps. A SWAMI process is used to define and isolate both polysilicon layers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
[Am]Mn(H<sub>2</sub>POO)<sub>3</sub>: A New Family of Hybrid Perovskites Based on the Hypophosphite Ligand (2017)

A family of five hybrid ABX<sub>3</sub> perovskites has been synthesized using hypophosphite (H<sub>2</sub>POO)<sup>-</sup> as the X-site ion. These compounds adopt the general formula [Am]Mn(H<sub>2</sub>POO)<sub>3</sub>, where Am = guanidinium (GUA), formamidinium (FA), imidazolium, triazolium, and dabconium. We explore the diverse structural and phase transition behavior of these materials through single-crystal diffraction measurements and demonstrate contrasting magnetism in two of the phases, Am = GUA and FA, that arises from structural distortions. The results show that hypophosphite perovskites offer a promising platform for generating new functional materials.
Rationale for transdermal drug administration in Alzheimer disease (2007)

Transdermal patches are used for the treatment of various diseases including neurologic and psychiatric disorders such as Parkinson disease (PD), major depression, and attention deficit hyperactivity disorder. They are believed to offer many advantages over conventional oral therapies. By providing smoother, continuous drug delivery and steadier plasma levels, patches may reduce the incidence of side effects, thus making optimal therapeutic doses easier to attain and potentially improving treatment efficacy and compliance. Drug delivery systems such as patches that are more patient- and caregiver-friendly may enable patients to continue treatment for longer periods and to attain greater, more sustained treatment benefits. To date, approved therapies for Alzheimer disease (AD), including cholinesterase inhibitors and memantine, are orally administered. Potential advantages associated with patches provide a therapeutic rationale to offer additional benefits in AD patients. Rivastigmine is well suited to patch administration because it is a small, potent molecule that is both lipophilic and hydrophilic. A rivastigmine patch has been developed and may provide a promising new approach to dementia therapy.
Hi-cites (1998)

Article Free Access Share on Hi-cites: dynamically created citations with active highlighting Authors: Michelle Q. Wang Baldonado Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CA Xerox Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Terry Winograd Gates 3B, Stanford University, Stanford, CA Gates 3B, Stanford University, Stanford, CAView Profile Authors Info & Claims CHI '98: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsJanuary 1998 Pages 408–415https://doi.org/10.1145/274644.274700Published:01 January 1998Publication History 6citation329DownloadsMetricsTotal Citations6Total Downloads329Last 12 Months10Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Design of tightly-coupled multiprocessing programming (1974)

Programming support of tightly-coupled multiprocessing hardware has been discussed, particularly the OS/VS2 Release 2 components: locking, service management, CPU affinity, dispatching, and alternate CPU recovery. These facilities improve the control program utilization of the two-cpu environment in that it can now run parallel disable functions. Alsos, pin time on locks is reduced, and the new dispatchable unit allows more parallelism in new system functions. Furthermore, the system is able to recover from the loss of one of the two CPUS.
Impact of an Intensive Care Unit Telemedicine Program on a Rural Health Care System (2009)

We evaluated the impact of a 15-hospital, rural, multi-state intensive care unit (ICU) telemedicine program. Acute Physiology, Age, and Chronic Health Evaluation (APACHE III) scores, raw mortality rates, and actual-to-predicted length of stay (LOS) ratios and mortality ratios were used. Surveys evaluated program impact in smaller facilities and satisfaction of the physicians staffing the remote center. Smaller facilities' staff reported improvements in the quality of critical care services and reduced transfers. In regional hospitals, acuity scores increased (retention of sicker patients) while raw mortality was the same or lower. Length of stay ratios were reduced in these hospitals. In the tertiary hospital, actual-to-predicted ICU and hospital mortality and LOS ratios decreased.
Optical phase-locking of 160 GHz optical beat to 40 GHz optical pulse train using a three-electrode DFB-LD and a Si avalanche photodiode (2005)

We successfully phase-locked 160 GHz optical beat to 40 GHz optical pulse train with RMS timing jitter 291 fs, using a three-electrode DFB-LD as optical VCO and a Si-APD as optical phase detector. (2 pages)