gebhart/patrepeval huggingface dataset:
Reactions during Vulcanization (1932)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions during VulcanizationHarlan A. DepewCite this: Ind. Eng. Chem. 1932, 24, 5, 565–568Publication Date (Print):May 1, 1932Publication History Published online1 May 2002Published inissue 1 May 1932https://pubs.acs.org/doi/10.1021/ie50269a023https://doi.org/10.1021/ie50269a023research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Ionic conductivity study of LiI-Ga<sub>2</sub>S<sub>3</sub>-GeS<sub>2</sub> chalcogenide glasses using a random-walk approach (2014)

Abstract Electrical properties of a set of lithium-ion conducting sulfide glasses with general formula 20LiI- x Ga 2 S 3 -(80- x )GeS 2 ( x = 10, 15 and 20) is studied in the present article. The experimental data obtained using impedance spectroscopy are analyzed by means of a random-walk ( RW ) model assuming that the conduction takes place by a random motion of Li + ions. The influences of added gallium on the structural network and on the conductivity of prepared glasses are also analyzed using the RW model. The results are further confirmed by Raman spectral analysis. The results obtained by the random-walk model and by a conventional equivalent electric circuit model are in a good agreement. We observed that the addition of Ga 2 S 3 contributed to phase separation in the prepared glassy system and negatively influenced the conductivity of the studied glasses. Factors contributing to the total conductivity with respect to the amount of both LiI and Ga 2 S 3 are also reported.
Incrementally lossless, broad-bandwidth analog fiber-optic link (2002)

Operation of a broadband, incrementally lossless, fiber-optic link is reported. By using a solid-state laser as the CW source, a dynamic range for this externally modulated link was measured and shown to exceed that of a directly modulated link. The modulator was a conventional Mach-Zehnder design. The average optical power on the detector was 20 mW. The modulator input and detector output are resistively terminated with 50 Omega , and the link RF-to-RF insertion loss vs. frequency is measured using an RF network analyzer. The maximum intermodulation-free (IM-free) dynamic range occurs at the optical modulation depth (OMD) for which the output intermodulation power equals the link output noise power. Consequently, the maximum IM-free dynamic range depends not only on the linearity of the modulating device, but also on the sources of noise in the link.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Hardware Approach to Real-Time Program Trace Compression for Embedded Processors (2007)

Collecting the program execution traces at full speed is essential to the analysis and debugging of real-time software behavior of a complex system. However, the generation rate and the size of real-time program traces are so huge such that real-time program tracing is often infeasible without proper hardware support. This paper presents a hardware approach to compress program execution traces in real time in order to reduce the trace size. The approach consists of three modularized phases: 1) branch/target filtering; 2) branch/target address encoding; 3) Lempel-Ziv (LZ)-based data compression. A synthesizable RTL code for the proposed hardware is constructed to analyze the hardware cost and speed and typical multimedia benchmarks are used to measure the compression results. The results show that our hardware is capable of real-time compression and achieving compression ratio of 454:1, far better than 5:1 achieved by typical existing hardware approaches. Furthermore, our modularized approach makes it possible to trade off between the hardware cost (typically from 1 to 50K gates) and the achievable compression ratio (typically from 5:1 to 454:1)
An Optically Controlled Microscale Elevator Using Plasmonic Janus Particles (2015)

In this article, we report how Janus particles, composed of a silica sphere with a gold half-shell, can be not only stably trapped by optical tweezers but also displaced controllably along the axis of the laser beam through a complex interplay between optical and thermal forces. Scattering forces orient the asymmetric particle, while strong absorption on the metal side induces a thermal gradient, resulting in particle motion. An increase in the laser power leads to an upward motion of the particle, while a decrease leads to a downward motion. We study this reversible axial displacement, including a hysteretic jump in the particle position that is a result of the complex pattern of a tightly focused laser beam structure above the focal plane. As a first application we simultaneously trap a spherical gold nanoparticle and show that we can control the distance between the two particles inside the trap. This photonic micron-scale "elevator" is a promising tool for thermal force studies, remote sensing, and optical and thermal micromanipulation experiments.
Space-Time Processing for CDMA Mobile Communications (2000)

List of Figures. List of Tables. Preface. 1. Introduction. 2. Basic Space-Time Aspects. 3. Aspects Influencing Space-Time Performance. 4. Space-Time Channel Models. 5. Smart Antenna Techniques. 6. Smart Antenna Performance. 7. Multiuser Detection. 8. Space-Time Coded Transmit Diversity for CDMA. Appendices. References. Index. About the Authors. Disclaimer.
Modeling and Simulation in Defense and Security: NATO Context (1999)

odeling and Simulation (M&S) are not new phenomena in the world of the military. Military training has always involved certain ways of simulating the reality of the battlefield. Depending on the level at which simulation was done it also involved more or less sophisticated modeling activities. The simulations could cover various aspects such as maneuvers, weapons used, own weapons as well as those the opponent was supposed to use and so on. The possibilities of modeling and simulation in the training area became well known after the Great explosion in the computer technology. Now the second stage in Modeling and Simulation is presented and this is the use of the Net for simulation.
1-[2-Methoxy-5-(3-phenylpropyl)]-2-aminopropane Unexpectedly Shows 5-HT<sub>2A</sub> Serotonin Receptor Affinity and Antagonist Character (2001)

Certain phenylethylamines, such as 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane (DOB; 1a), are high-affinity 5-HT2 agonists. Previous structure−affinity studies have concluded that both the 2,5-dimethoxy substitution pattern and the nature of substituents at the 4-position are important determinants of high affinity. We recently demonstrated that replacement of the bromo group of DOB with a 3-(phenyl)propyl substituent results in retention of affinity and that, counter to established structure−affinity relationships, the 2,5-dimethoxy substitution pattern is no longer a requirement for the binding. The present investigation extends these findings by examining a series of analogues, 3, lacking a 5-methoxy group. It was additionally found that shifting the phenylalkyl substituent from the 4- to the 5-position (e.g., 4i) also results in retention of affinity. For example, 1-(2-methoxy-5-(3-phenylpropyl)-2-aminopropane (6; the α-methyl derivative of 4i) binds at 5-HT2A receptors with high affinity (Ki = 13 nM) and possesses 5-HT2A antagonist character. Thus, not only is the 2,5-dimethoxy substitution pattern not a requirement for the binding of certain phenylethylamines at 5-HT2A receptors, the presence of a 4-position substituent (previously thought to serve as a modulator of affinity of DOB-like agents) is also not required. Striking differences in the 5-HT2A binding requirements of the present compounds as compared to DOB-like agents suggest multiple substituent-dependent modes of binding.
Susceptibility to klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points (2014)

Klebsiella pneumoniae (Kp) is a bacterium causing severe pneumonia in immunocompromised hosts and is often associated with sepsis. With the rise of antibiotic resistant bacteria, there is a need for new effective and affordable control methods; understanding the genetic architecture of susceptibility to Kp will help in their development. We performed the first quantitative trait locus (QTL) mapping study of host susceptibility to Kp infection in immunocompetent Collaborative Cross mice (CC). We challenged 328 mice from 73 CC lines intraperitoneally with 104 colony forming units of Kp strain K2. Survival and body weight were monitored for 15 days post challenge. 48 of the CC lines were genotyped with 170,000 SNPs, with which we mapped QTLs. CC lines differed significantly (P < 0.05) in mean survival time, between 1 to 15 days post infection, and broad sense heritability was 0.45. Distinct QTL were mapped at specific time points during the challenge. A QTL on chromosome 4 was found only on day 2 post infection, and QTL on chromosomes 8 and 18, only on day 8. By using the sequence variations of the eight inbred strain founders of the CC to refine QTL localization we identify several candidate genes. Host susceptibility to Kp is a complex trait, controlled by multiple genetic factors that act sequentially during the course of infection.
The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence (2015)

We identified SR-BI to indicate human prostate cancer formation, suggesting that increased levels of SR-BI may be involved in the generation of a castration-resistant phenotype.
Correction of satellite imagery over mountainous terrain (1998)

A method for the radiometric correction of satellite imagery over mountainous terrain has been developed to remove atmospheric and topographic effects. The algorithm accounts for horizontally varying atmospheric conditions and also includes the height dependence of the atmospheric radiance and transmittance functions to simulate the simplified properties of a three-dimensional atmosphere. A database has been compiled that contains the results of radiative transfer calculations (atmospheric transmittance, path radiance, direct and diffuse solar flux) for a wide range of weather conditions. A digital elevation model is used to obtain information about surface elevation, slope, and orientation. Based on the Lambertian assumption the surface reflectance in rugged terrain is calculated for the specified atmospheric conditions. Regions with extreme illumination geometries sensitive to BRDF effects can be optionally processed separately. The method is restricted to high spatial resolution satellite sensors with a small swath angle such as the Landsat thematic mapper and Systeme pour l'Observation de la Terre high resolution visible, since some simplifying assumptions were made to reduce the required image processing time.
Advanced imaging research and development at DARPA (2012)

Advances in imaging technology have huge impact on our daily lives. Innovations in optics, focal plane arrays (FPA), microelectronics and computation have revolutionized camera design. As a result, new approaches to camera design and low cost manufacturing is now possible. These advances are clearly evident in visible wavelength band due to pixel scaling, improvements in silicon material and CMOS technology. CMOS cameras are available in cell phones and many other consumer products. Advances in infrared imaging technology have been slow due to market volume and many technological barriers in detector materials, optics and fundamental limits imposed by the scaling laws of optics. There is of course much room for improvements in both, visible and infrared imaging technology. This paper highlights various technology development projects at DARPA to advance the imaging technology for both, visible and infrared. Challenges and potentials solutions are highlighted in areas related to wide field-of-view camera design, small pitch pixel, broadband and multiband detectors and focal plane arrays.
Effects of Different Lipid Sources in Total Parenteral Nutrition on Whole Body Protein Kinetics and Tumor Growth (1992)

This study examined the short-term effects of three total parenteral nutrition solutions, each containing a different lipid source, on host and tumor protein metabolism in a rat cancer model. Each diet contained 220 kcal/kg per day, including 2 g of nitrogen/kg per day and 50% of nonprotein calories as either a structured lipid of medium-chain triglycerides and fish oil, a physical mix of medium-chain triglycerides and fish oil, or Liposyn II, a long-chain triglyceride. A 3-day intravenous feeding infusion began on day 7 after tumor implantation. Tumor growth rate, nitrogen balance, energy expenditure, and plasma albumin, glucose, and free fatty acids were measured, and whole body protein kinetics and fractional synthetic rates in liver, muscle, and tumor tissues were assessed using a constant infusion of 14C-leucine. The results revealed that tumor growth rate was slowed in structured lipid-fed animals (p = .06, one-way analysis of variance) with significant increases in rates of tumor protein synthesis and tumor protein breakdown (p < .001, one-way analysis of variance). Although muscle fractional synthetic rates were significantly decreased in tumor-bearing animals (p < .05, two-way analysis of variance), the rates in structured lipid-fed animals were restored. Nitrogen balance improved significantly in structured lipid-fed animals. The results demonstrate that the source of lipid in total parenteral nutrition solutions can influence tumor and host protein metabolism, and that a structured lipid composed of medium-chain triglycerides and fish oil seems to improve protein metabolism in host tissue without stimulating tumor growth.
A robust wheelchair pressure relief monitoring system (2012)

It is essential to prevent pressure ulcers for people with spinal cord injuries (SCI). Pressure ulcer is likely to develop when there is excessive pressure on the body tissue for lengthy durations. Therefore, persons with SCI, who usually spend long time sitting in wheelchairs, are advised to perform regular pressure reliefs in their daily lives. This paper proposes a system for the monitoring of wheelchair users' pressure relief behaviors. The system utilizes piezo resistive sensors beneath a wheelchair cushion to monitor pressure, and employs supervised learning techniques to classify a wheelchair user's pressure relief status. Key features of the system include robustness and not interfering with cushion performance or the daily activities of wheelchair users. The system works well on different types of cushions, and achieves 91% sensitivity and 89% specificity based on tests on different wheelchair users.
Selection of Nanobodies that Target Human Neonatal Fc Receptor (2013)

FcRn is a key player in several immunological and non-immunological processes, as it mediates maternal-fetal transfer of IgG, regulates the serum persistence of IgG and albumin, and transports both ligands between different cellular compartments. In addition, FcRn enhances antigen presentation. Thus, there is an intense interest in studies of how FcRn binds and transports its cargo within and across several types of cells, and FcRn detection reagents are in high demand. Here we report on phage display-selected Nanobodies that target human FcRn. The Nanobodies were obtained from a variable-domain repertoire library isolated from a llama immunized with recombinant human FcRn. One candidate, Nb218-H4, was shown to bind FcRn with high affinity at both acidic and neutral pH, without competing ligand binding and interfering with FcRn functions, such as transcytosis of IgG. Thus, Nb218-H4 can be used as a detection probe and as a tracker for visualization of FcRn-mediated cellular transport.
Regulation of Cutaneous Previtamin D <sub>3</sub> Photosynthesis in Man: Skin Pigment Is Not an Essential Regulator (1981)

When human skin was exposed to simulated solar ultraviolet radiation, epidermal 7-dehydrocholesterol was converted to previtamin D3. During prolonged exposure to simulated solar ultraviolet radiation, the synthesis of previtamin D3 reached a plateau at about 10 to 15 percent of the original 7-dehydrocholesterol content, and previtamin D3 was photoisomerized to two biologically inert isomers, lumisterol3 and tachysterol3. Increases either in skin melanin concentration or in latitude necessitated increases in the exposure time to simulated solar ultraviolet radiation required to maximize the formation, but not the total content, of previtamin D3. In order of importance, the significant determinants limiting the cutaneous production of previtamin D3 are (i) photochemical regulation, (ii) pigmentation, and (iii) latitude.
A study on processing about carbonitriding pinion steel for heavy load (2010)

The technique of smelting and press working of high carbonitriding pinion steel 18CrMnNiMoA for heavy load was introduced and the quality of steel production was analysed.The factors of influencing the property of steel were discussed based on the chemical composition and smelting processing.The measures of adding trace elements and using thermo-mechanical control process(TMCP),which were for refining the grain size of steel,were proposed.
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements (2012)

JAK2 fusion genes are rare but recurrent abnormalities associated with diverse, clinically heterogeneous hematologic malignancies. Here we assess the JAK1/2 inhibitor ruxolitinib as therapy for patients with JAK2-rearrangement associated myeloproliferative neoplasms (MPN). Ruxolitinib-treated Ba/F3 cells transformed to IL3 independence by ETV6-JAK2 showed reduced proliferation and survival (IC(50) = 370 nM) compared with KG1A or Ba/F3 cells transformed by BCR-ABL1, SPBN1-FLT3 and ZMYM2-FGFR1 (IC(50) > 10 μM for all). Inhibition was associated with reduced phosphorylation of ETV6-JAK2, ERK, STAT5 and AKT. Primary cell growth from 2 patients with JAK2 rearrangement and one patient with JAK2 amplification was assessed in methylcellulose assays. Reduced colony growth was seen for all patients in ruxolitinib-treated cultures compared with healthy controls (n=7). Fluorescence in situ hybridization showed reduced growth of JAK2-rearrangement positive colonies compared to JAK2-rearrangement negative colonies. Our data, therefore, provide evidence that ruxolitinib is a promising therapy for treatment of patients with JAK2 fusion genes.
Recovery of Mitral Isthmus Conduction Leads to the Development of Macro-Reentrant Tachycardia After Left Atrial Linear Ablation for Atrial Fibrillation (2011)

Despite using bidirectional conduction block as a procedural end point, recovery of MI conduction is common and may lead to LAT after left atrial linear ablation for AF. The reason for greater recovery of MI versus CTI conduction is unknown but could be due to differences in isthmus anatomy or lower power used for ablation in the left versus right atrium.
HIF1<i>α</i> Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2 (2013)

Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular anabolic requirements, thus potentially inducing cancer-like metabolic transformation. Accordingly, we and others previously showed that somatic mitochondria and bioenergetics are extensively remodeled upon derivation of induced pluripotent stem cells (iPSCs), as the cells transit from oxidative to glycolytic metabolism. In the attempt to identify possible regulatory mechanisms underlying this metabolic restructuring, we investigated the contributing role of hypoxia-inducible factor one alpha (HIF1α), a master regulator of energy metabolism, in the induction and maintenance of pluripotency. We discovered that the ablation of HIF1α function in dermal fibroblasts dramatically hampers reprogramming efficiency, while small molecule-based activation of HIF1α significantly improves cell fate conversion. Transcriptional and bioenergetic analysis during reprogramming initiation indicated that the transduction of the four factors is sufficient to upregulate the HIF1α target pyruvate dehydrogenase kinase (PDK) one and set in motion the glycolytic shift. However, additional HIF1α activation appears critical in the early upregulation of other HIF1α-associated metabolic regulators, including PDK3 and pyruvate kinase (PK) isoform M2 (PKM2), resulting in increased glycolysis and enhanced reprogramming. Accordingly, elevated levels of PDK1, PDK3, and PKM2 and reduced PK activity could be observed in iPSCs and human embryonic stem cells in the undifferentiated state. Overall, the findings suggest that the early induction of HIF1α targets may be instrumental in iPSC derivation via the activation of a glycolytic program. These findings implicate the HIF1α pathway as an enabling regulator of cellular reprogramming.
Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. (1986)

An atrial natriuretic factor (ANF) receptor from rat lung was solubilized with Lubrol-PX and purified by sequential chromatographic steps on GTP-agarose, DEAE-Sephacel, phenyl-agarose, and wheat germ agglutinin-agarose. The ANF receptor was enriched 19,000-fold. The purified receptor has a binding profile and properties that correspond to the affinity and specificity found in membranes and crude detergent extracts. Polyacrylamide gel electrophoresis of the purified preparation in the presence of sodium dodecyl sulfate and dithiothreitol showed the presence of one major protein band with a molecular mass of 120,000 daltons. When purified preparations were incubated with 125I-ANF, then cross-linked with disuccinimidyl suberate, the 120,000-dalton protein was specifically radiolabeled. This high affinity binding site for ANF co-purified with particulate guanylate cyclase. Particulate guanylate cyclase was purified to a specific activity of 19 mumol cyclic GMP produced/min/mg of protein utilizing Mn-GTP as substrate. This represented a 15,000-fold purification compared to the initial lung membrane preparation with Lubrol-PX. Gel permeation high performance liquid chromatography and glycerol density gradient sedimentation studies of the purified preparation also resulted in co-migration of specific ANF binding and guanylate cyclase activities. The co-purification of these activities suggests that both ANF binding and guanylate cyclase activities reside in the same macromolecular complex. Presumably ANF binding occurs at the external membrane surface and cyclic GMP synthesis at the internal membrane surface of this transmembrane glycoprotein.