gebhart/patrepeval huggingface dataset:
Regulation of the Natural Killer Cell Receptor Repertoire (2001)

Natural killer cells express inhibitory receptors specific for MHC class I proteins and stimulatory receptors with diverse specificities. The MHC-specific receptors discriminate among different MHC class I alleles and are expressed in a variegated, overlapping fashion, such that each NK cell expresses several inhibitory and stimulatory receptors. Evidence suggests that individual developing NK cells initiate expression of inhibitory receptor genes in a sequential, cumulative, and stochastic fashion. Superimposed on the receptor acquisition process are multiple education mechanisms, which act to coordinate the stimulatory and inhibitory specificities of developing NK cells. One process influences the complement of receptors expressed by individual NK cells. Other mechanisms may prevent NK cell autoaggression even when the developing NK cell fails to express self-MHC-specific inhibitory receptors. Together, these mechanisms ensure a self-tolerant and maximally discriminating NK cell population. Like NK cells, a fraction of memory phenotype CD8(+) T cells, as well as other T cell subsets, express inhibitory class I--specific receptors in a variegated, overlapping fashion. The characteristics of these cells suggest that inhibitory receptor expression may be a response to prior antigenic stimulation as well as to poorly defined additional signals. A unifying hypothesis is that both NK cells and certain T cell subsets initiate expression of inhibitory receptors in response to stimulation.
Seed protein, fat and fatty acid profile of <i>Amaranthus</i> species (1992)

Abstract The protein, fat and fatty acid composition in the seeds of 41 lines of amaranth Amaranthus spp including both the grain and vegetable types were analysed. Protein varied from 103 to 183 g kg −1 and fat from 8 to 68 g kg −1 . Hexadecanoic, octadecenoic and octadecadienoic acids were the major fatty acids of the oil.
STF behaviour in a CT ΔΣ modulator (2005)

In this paper we propose a topology for continuous time SigmaDelta modulators. Unlike the modulators presented until now, they exhibit no peaking in their signal transfer function. Instead it achieves a 'flat' STF with the desired anti-aliasing properties and with small internal nodes signal levels. Now, a simple filter, e.g. a first-order low-pass filter can precede the modulator to prevent out of band signals corrupting the correct operation of the modulator.
Sex Pheromone of the Moth,Pandemis pyrusana12 (1977)

The sex pheromone components of Pandemis pyrusana Kearfott (Lepidoptera: Tortricidae) were identified as ( Z )-11-tetradecenyl acetate and ( Z )-9-tetradecenyl acetate in a 94:6 ratio. They are the same pheromone components (91:9) found in the allopatric species Pandemis limitata (Robinson).
High-Throughput Detection of Clinically Relevant Mutations in Archived Tumor Samples by Multiplexed PCR and Next-Generation Sequencing (2014)

MMP-seq provides a robust solution for comprehensive, reliable, and high-throughput genetic profiling of clinical tumor samples, paving the way for the incorporation of genomic-based testing into clinical investigation and practice.
Hammett Correlations of Carbonyl 13C Chemical Shifts in a Series of N-(4-Substituted Phenyl)-6-Chloro-5-Fluoronicotinamides (1995)

A series of nine N-(4-substituted phenyl)-6-chloro-5- fluoronicotinamides exhibited excellent correlations of their carbonyl 13C shifts (5CO,ppm as measured in DMSO) with the standard Hammett substituent constants (c?R) of the substituent inthe 4-position. The linear relationship was defined by the equation 8CO ¦ 1.22
Simulation Study of Implantation Angle Variation and Its Impact on Device Performance (2016)

A simulation platform was established to evaluate device performance affected by ion implantation angle variation. Modeling of a one-dimensional wafer scanning system was performed to estimate the angle variation. Process simulation for fin field effect transistors (FinFET) revealed that twist angle affects dopant dose retention in the fin structure. However, the fin structure twists as the arm holding the wafer rotates during scanning. This causes twist angle variation which depends on the length of the rotation arm and the tilt angle. Maximum variation in twist angle occurs near the bottom edge of the wafer. Such variation may increase device driving and leakage current when more twist angle results in more dopant retention in the source/drain extension regions.
Direct Instrumental Conditioning of Neural Activity Using Functional Magnetic Resonance Imaging-Derived Reward Feedback (2007)

Successful learning is often contingent on feedback. In instrumental conditioning, an animal or human learns to perform specific responses to obtain reward. Instrumental conditioning is often used by behavioral psychologists to train an animal (or human) to produce a desired behavior. Shaping involves reinforcing those behaviors, which in a stepwise manner are successively closer to the desired behavior until the desired behavior is reached. Here, we aimed to extend this traditional approach to directly shape neural activity instead of overt behavior. To achieve this, we scanned 22 human subjects with functional magnetic resonance imaging and performed image processing in parallel with acquisition. We delineated regions of interest (ROIs) in finger and toe motor/somatosensory regions and used an instrumental shaping procedure to induce a regionally specific increase in activity by providing an explicit monetary reward to reinforce neural activity in the target areas. After training, we found a significant and regionally specific increase in activity in the ROI being rewarded (finger or toe) and a decrease in activity in the nonrewarded region. This demonstrates that instrumental conditioning procedures can be used to directly shape neural activity, even without the production of an overt behavioral response. This procedure offers an important alternative to traditional biofeedback-based approaches and may be useful in the development of future therapies for stroke and other brain disorders.
Automating Component Dependency Analysis for Enterprise Business Intelligence (2014)

We address common problems in the field of Business Intelligence, Data Warehousing and Decision Support Systems: the complexity to manage, track and understand data lineage and system component dependencies in long series of data transformation chains. The paper presents practical methods to calculate meaningful data transformation and component dependency paths, based on program parsing, heuristic impact analysis, probabilistic rules and semantic technologies. Case studies are employed to explain further data aggregation and visualization of the results to address different planning and decision support problems for various groups of technical and business users.
Solution-processed inorganic semiconductors (2004)

The search for semiconductors that can be solution-processed into thin-film form at low temperature, while simultaneously providing quality device characteristics, represents a significant challenge for materials chemists. Continuous thin films with field-effect mobilities of 10 cm2 V−1 s−1 or greater are particularly desirable for high-speed microelectronic applications. Attainment of this goal should provide important opportunities for electronic devices, including potentially low-cost, large-area and flexible computing devices, displays, sensors and solar cells. While the majority of work toward this goal has focused on organic semiconductors (both molecular and polymeric), with highest reported mobilties in the range of 1 cm2 V−1 s−1, this review will address recent developments in the search for semiconductors with extended inorganic frameworks (offering the potential for higher mobility) that can be processed from solution using high-throughput, low-cost and low-temperature techniques such as spin-coating, printing or stamping. Two areas of recent interest will be highlighted – tin(II) iodide based organic–inorganic hybrids and soluble chalcogenide semiconductors. Application of the resulting thin films in devices will primarily be discussed in terms of thin-film field-effect transistors (TFTs), although other device applications can be envisioned.
Combination of ring-opening polymerization and “click” chemistry towards functionalization of aliphatic polyesters (2005)

Azide pendent groups of aliphatic polyesters have been derivatized into tertiary amines, ammonium salts and poly(ethylene oxide) grafts. The experimental conditions have been optimized (organic solvent, 35 degrees C), such that the aliphatic polyesters are not degraded, including even poly(lactide) which is very sensitive to attack by weak nucleophiles.
Forebody Flow Visualization on the F-18 HARV With Actuated Forebody Strakes (1998)

Off-surface smoke flow visualization and extensive pressure measurements were obtained on the forebody of the NASA F-18 High Alpha Research Vehicle equipped with actuated forebody strakes. Test points at alpha = 50 deg. were examined in which only one strake was deflected or in which both strakes were deflected differentially. The forebody pressures were integrated to obtain forebody yawing moments. Results showed that small single strake deflections can cause an undesirable yawing moment reversal. At alpha = 50 deg., this reversal was corrected by deploying both strakes at 20 deg. initially, then differentially from 20 deg. to create a yawing moment. The off-surface flow visualization showed that in the case of the small single strake deflection, the resulting forebody/strake vortex remained close to the surface and caused accelerated flow and increased suction pressures on the deflected side. When both strakes were deflected differentially, two forebody/strake vortices were present. The forebody/strake vortex from the larger deflection would lift from the surface while the other would remain close to the surface. The nearer forebody/strake vortex would cause greater flow acceleration, higher suction pressures and a yawing moment on that side of the forebody. Flow visualization provided a clear description of the strake vortices fluid mechanics.
<i>Debaryomyces hansenii</i> — an extremophilic yeast with biotechnological potential (2006)

We illuminate the ecological, physiological and genetic characteristics of the yeast Debaryomyces hansenii in the view of our belief that this metabolically versatile, non-pathogenic, osmotolerant and oleaginous microorganism represents an attractive target for fundamental and applied biotechnological research. To this end, we give a broad overview of extant biotechnological procedures using D. hansenii, e.g. in the manufacture of various foods, and propose research into the heterologous synthesis of a range of fine chemicals.
Surfaces Forces between Silica Surfaces in Cationic Surfactant Solutions: Adsorption and Bilayer Formation at Normal and High pH (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurfaces Forces between Silica Surfaces in Cationic Surfactant Solutions: Adsorption and Bilayer Formation at Normal and High pHMark W. Rutland and John L. ParkerCite this: Langmuir 1994, 10, 4, 1110–1121Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/la00016a024https://doi.org/10.1021/la00016a024research-articleACS PublicationsRequest reuse permissionsArticle Views735Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aberrant NF-κB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor (2008)

Focal necrosis is a key pathologic feature that distinguishes glioblastoma from lower grade glioma. The presence of necrosis in a glioblastoma could promote its rapid growth and clinical progression. Focal necrosis of glioblastoma seems to be associated with thrombosis that result from hyper-coagulability. In the present study, we found that glioblastoma cells had a high level of constitutive nuclear factor (NF)-kappaB activity, which was directly correlated with necrosis in glioblastomas. We also found a direct correlation between NF-kappaB activity and the expression of tissue factor (TF), a potent procoagulant factor in gliomas. Inhibition of TF by an inhibitory antibody prevented the procoagulant activity of glioblastoma cells, indicating a TF-dependent mechanism. Blockade of NF-kappaB activation significantly inhibited TF expression and the procoagulant activity of glioblastoma cells in vitro. Blockade of NF-kappaB activation also significantly inhibited in vivo expression of TF, which was directly correlated with decreased necrosis formation and tumor growth of glioblastoma cells in nude mice. Collectively, these results suggest that elevated NF-kappaB activity in glioblastomas cells plays a critical role in necrosis formation of glioblastoma and that inhibition of NF-kappaB activity in glioblastoma can suppress necrosis formation and progressive growth.
用1,3—双（柠康酰亚氨基亚甲基）—苯改善胎面磨耗性和生热性 (1999)

硫黄硫化的硫化胶,特别是NR和IR硫化胶的硫化返原现象是广为人知的。如果交联网络中多数是多硫交联键,则该网络在经受了长时间高温作用之后就会变性,即产生硫化返原。硫化返原致使各种交联键的分布产生变化,交联密度降低,结果是力学性能受损。
Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure. (1998)

It is concluded that exogenous GLP-1 effectively lowers plasma glucose concentrations in advanced type 2 diabetes long after sulfonylurea secondary failure. These findings may broaden the applicability of GLP-1-derived drugs as a new treatment to nearly all type 2 diabetic patients.
The USTC-NEL Speech Translation system at IWSLT 2018 (2018)

This paper describes the USTC-NEL system to the speech translation task of the IWSLT Evaluation 2018. The system is a conventional pipeline system which contains 3 modules: speech recognition, post-processing and machine translation. We train a group of hybrid-HMM models for our speech recognition, and for machine translation we train transformer based neural machine translation models with speech recognition output style text as input. Experiments conducted on the IWSLT 2018 task indicate that, compared to baseline system from KIT, our system achieved 14.9 BLEU improvement.
PEGASIS: Power-efficient gathering in sensor information systems (2003)

Sensor webs consisting of nodes with limited battery power and wireless communications are deployed to collect useful information from the field. Gathering sensed information in an energy efficient manner is critical to operate the sensor network for a long period of time. In W. Heinzelman et al. (Proc. Hawaii Conf. on System Sci., 2000), a data collection problem is defined where, in a round of communication, each sensor node has a packet to be sent to the distant base station. If each node transmits its sensed data directly to the base station then it will deplete its power quickly. The LEACH protocol presented by W. Heinzelman et al. is an elegant solution where clusters are formed to fuse data before transmitting to the base station. By randomizing the cluster heads chosen to transmit to the base station, LEACH achieves a factor of 8 improvement compared to direct transmissions, as measured in terms of when nodes die. In this paper, we propose PEGASIS (power-efficient gathering in sensor information systems), a near optimal chain-based protocol that is an improvement over LEACH. In PEGASIS, each node communicates only with a close neighbor and takes turns transmitting to the base station, thus reducing the amount of energy spent per round. Simulation results show that PEGASIS performs better than LEACH by about 100 to 300% when 1%, 20%, 50%, and 100% of nodes die for different network sizes and topologies.
Ubiquitin-Specific Proteases 25 Negatively Regulates Virus-Induced Type I Interferon Signaling (2013)

Ubiquitination and deubiquitination have emerged as critical regulatory processes in the virus-triggered type I interferon (IFN) induction pathway. In this study, we carried out a targeted siRNA screen of 54 ubiquitin-specific proteases (USPs) and identified USP25 as a negative regulator of the virus-triggered type I IFN signaling pathway. Overexpression of USP25 inhibited virus-induced activation of IFN-β, interferon regulation factor 3 (IRF3) and nuclear factor-kappa B (NF-κB), as well as the phosphorylation of IRF3 and NF-κB subunit p65. Furthermore, Knockdown of USP25 potentiated virus-induced induction of the IFN-β. In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607). USP25 mutants lacking DUB activity lost the ability to block virus-induced type I IFN to some degree. Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling. Our findings suggest that USP25 is a novel DUB negatively regulating virus-induced type I IFN production.
A Beam Corrected Estimation of the Frequency Dependent Attenuation of Biological Tissues from Backscattered Ultrasound (1983)

A practical and highly accurate method of estimation of the frequency-dependent slope of the acoustic attenuation coefficient, alpha 1, using backscattered ultrasound energy is presented. The influence of the focused ultrasound beam is experimentally measured and a simple method for incorporating the field effects in the estimate of alpha 1 is described. The accuracy of the estimate of alpha 1 in vitro which appears to be of the order of 10 percent, demonstrates the feasibility of in vivo applications of the technique.
Materials, design and manufacturing for lightweight vehicles (2010)

Introduction. Part 1 Materials for lightweight automotive structures: Advanced steels for lightweight automotive structures Aluminium alloys for lightweight automotive structures Magnesium alloys for lightweight powertrains and automotive structures Thermoplastics and thermoplastic-matrix composites for lightweight automotive structures Thermoset-matrix composites for lightweight automotive structures. Part 2 Manufacturing and design of lightweight automotive structures: Manufacturing processes for light alloys Joining for lightweight vehicles Recycling and lifecycle issues for lightweight vehicles Crashworthiness design issues for lightweight vehicles.
Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling. (1992)

We labeled rat adipocyte cell surface glucose transporters with an impermeable, photoreactive glucose analogue, 1,3-bis-(3-deoxy-D-glucopyranose-3-yloxy)-2-propyl 4-benzoylbenzoate (B3GL) and its radioactive tracer [3H]B3GL. The labeling did not affect glucose transporter subcellular distribution in basal and insulin-stimulated adipocytes. When basal or insulin-stimulated adipocytes were labeled with [3H]B3GL and incubated at 37 degrees C in steady state, labeled GLUT4 was rapidly reduced at the cell surface and stoichiometrically recovered in microsomes without any change in GLUT4 protein levels in either pool. The labeled GLUT4 equilibrium exchange was found to be a simple first order process describable by two first order rate constants, one for internalization (k(in)) and the other for externalization (kex). Insulin affected both rate constants, reducing k(in) by 2.8-fold and increasing kex by 3.3-fold. It is concluded that GLUT4 constantly and rapidly recycles in adipocytes between the cell surface and its storage pool, and insulin increases the cell surface GLUT4 level in rat adipocytes by modulating both the internalization and the externalization steps of constitutively recycling GLUT4.
Solar Cell Efficiency Improvement by New Metallization Techniques - the Day4 Electrode Concept (2006)

The standard module cell interconnection technique requires printed Ag front side busbars and rear side Ag/Al pads. From the standpoint of cell performance these contacts reduce cell efficiency strongly as a result of large cell shading and reduced surface passivations. Cells without busbars and pads would show a cell current and voltage increase and simplify the printing procedure. In this paper we introduce a new cell metallization technique which could be directly applied to standard industrial cells eliminating the need for rear pads and front busbars. Experiments were carried out to study the current and voltage gain of modified cells with the proviso that the cell fill factor will maintain at high level. Optimization experiments showed up to 0.8% higher cell efficiency for modified cells if compared to reference cells. Technique was furthermore successfully applied to 8 inch cells which showed fill factors of 77.9%
Ward level evaluation of the "One Touch" glucose meter. (1988)

Journal Article Ward level evaluation of the "One Touch" glucose meter. Get access M L Leroux, M L Leroux Dept. of Clin. Chem., Health Sciences Centre, Winnipeg, Manitoba, Canada Search for other works by this author on: Oxford Academic Google Scholar P R Desjardins P R Desjardins Dept. of Clin. Chem., Health Sciences Centre, Winnipeg, Manitoba, Canada Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 34, Issue 9, 1 September 1988, Page 1928, https://doi.org/10.1093/clinchem/34.9.1928a Published: 01 September 1988
LATENT ADENOVIRUS INFECTIONS OF THE HUMAN RESPIRATORY TRACT1 (1958)

Journal Article LATENT ADENOVIRUS INFECTIONS OF THE HUMAN RESPIRATORY TRACT Get access ALFRED S. EVANS, ALFRED S. EVANS Search for other works by this author on: Oxford Academic PubMed Google Scholar B. EVANS, B. EVANS Search for other works by this author on: Oxford Academic PubMed Google Scholar G. GOGAT G. GOGAT Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 67, Issue 3, May 1958, Pages 256–266, https://doi.org/10.1093/oxfordjournals.aje.a119932 Published: 01 May 1958 Article history Received: 29 January 1958 Published: 01 May 1958