gebhart/patrepeval huggingface dataset:
Molecular asymmetry. IX. Partial resolution and asymmetric synthesis of 1,2-cyclononadiene (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular asymmetry. IX. Partial resolution and asymmetric synthesis of 1,2-cyclononadieneArthur C. Cope, William Robert Moore, Robert D. Bach, and Hans J. S. WinklerCite this: J. Am. Chem. Soc. 1970, 92, 5, 1243–1247Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ja00708a023https://doi.org/10.1021/ja00708a023research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biosynthesis of intestinal microvillar proteins. Characterization of intestinal explants in organ culture and evidence for the existence of pro-forms of the microvillar enzymes (1982)

Explants of pig small intestine were maintained at 37 degrees C in organ culture for periods up to 24 h in a system using Trowell T-8 medium supplemented with 10% foetal-calf serum. The mucosal morphology was well preserved during culture, as judged by light and electron microscopy. The explant contents of protein and two brush-border enzymes, microvillus aminopeptidase (EC 3.4.11.2) and dipeptidyl peptidase IV (EC 3.4.14.5), were not significantly modified during culture compared with controls, but a moderate, continuous release of both protein and enzyme activities into the medium was observed. Continuous labelling with [35S]methionine resulted in an even incorporation of radioactivity in the protein components, and the rate of labelling only moderately decreased over the 24 h period. The polypeptide compositions of sucrase (EC 3.2.1.48)--isomaltase (EC 3.2.1.10), maltase--glucoamylase (EC 3.2.1.20) lactase (EC 3.2.1.23)--phlorizin hydrolase (EC 3.2.1.62), microvillus aminopeptidase and aspartate aminopeptidase (EC 3.4.11.7) synthesized during culture were studied, and some were found to be similar to those of the pro-forms of the enzymes isolated from animals that had had their pancreatic duct disconnected 3 days before being killed. These results confirmed earlier findings of the existence of pro-forms of some of the microvillar enzymes and thus indicate a low activity of pancreatic proteinases in the culture system.
Non-invasive estimation of blood glucose a feasibility study (2013)

The present work demonstrates the feasibility of estimating blood glucose level using a microstrip antenna strapped on a patient's arm. Some promising success has been shown by the RIT ETA Lab research group that an antenna's resonant frequency can track, in real time, changes in glucose concentration. However, these changes in antenna response are unique to an individual. An equivalent circuit model has been developed to represent the input impedance with changing glucose levels. From a first set of measurements of input impedance in real time on a patient, the circuit elements are determined by curve fitting, in terms of the change in glucose level and incorporated into the expression for input impedance of the equivalent circuit The glucose level is estimated iteratively from subsequent measurements of the input impedance on the same patient The estimates, represented in the Clarke's Error Grid, compare well with the measurements made by a traditional blood glucose meter.
Acute Effects of Antileukotrienes on Sinonasal Polyposis and Sinusitis (2000)

Recently, leukotrienes have been implicated in the mediation of bronchoconstriction and inflammatory changes in asthma. Leukotriene levels have also been shown to be elevated in patients with asthma as well as in those with sinonasal polyposis and sinusitis. The leukotriene synthesis inhibitor zileuton and the leukotriene receptor antagonist zafirlukast have been shown to produce subjective and objective improvements in patients with mild to moderate asthma. Given these findings, we evaluated the efficacy of these two medications in controlling sinonasal polyposis and their associated symptoms. We treated 40 patients diagnosed with sinonasal polyposis and sinusitis with either zileuton or zafirlukast. No other change was made in their standard therapy. Outcome measures included subjective interviews and questionnaire responses, as well as office endoscopic examinations and chart reviews. At study's end, 36 patients were available for evaluation. Twenty-six had taken zafirlukast, five had taken zileuton, and five others had switched from zafirlukast to zileuton. Overall, 26 patients (72%) experienced subjective improvement in their symptomatology after starting their medication. Statistically significant improvement was noted with respect to headache, facial pain and pressure, ear discomfort, dentalgia, purulent nasal discharge, postnasal drip, nasal congestion and obstruction, olfaction, and fever. An objective alleviation, or at least stabilization, of sinonasal polyposis was seen in 50% of the patients. Four patients (11%) discontinued their medication because of side effects. We conclude that antileukotrienes might play a significant role in controlling polyposis and symptoms secondary to sinonasal disease, and they might be a viable alternative to long-term oral steroid therapy and repeated surgical debridement.
Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. (1995)

A novel immunoglobulin-type protein expressed in blood vessels has been identified. The cDNA for AAMP (angio-associated, migratory cell protein) was first isolated from a human melanoma cell line during a search for motility-associated cell surface proteins. Upon analysis of the tissue distribution of AAMP, it was found to be expressed strongly in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics. The sequence of AAMP predicts a protein (M(r) 49,000) with distant identity (25%) to known proteins. It contains immunoglobulin-like domains [one with multiple homologies to deleted in colon carcinoma (DCC) protein], the WD40 repeat motif, and a heparin-binding consensus sequence. A 1.6-kilobase mRNA transcript of AAMP is detected in tissue culture cell lines and tissues. Affinity-purified polyclonal antibodies, anti-recombinant AAMP, and anti-peptide 189 (AAMP derived) recognize a M(r) 52,000 protein in human tissue and cellular extracts. The protein size is in keeping with the mRNA and predicted sequence. The AAMP-derived peptide, P189, contains a heparin-binding domain (dissociation constant, 14 pmol) and mediates heparin-sensitive cell adhesion. The shared expression of AAMP in endothelial cells, trophoblasts, and tumor cells implies a common function in migrating cells.
Mechanism of Water Splitting and Oxygen−Oxygen Bond Formation by a Mononuclear Ruthenium Complex (2009)

Density functional theory (DFT) predicts a detailed mechanism for the reported potential photocatalytic system for solar hydrogen production from water, (P-da-PNN)RuH(CO) (1, P-da = dearomatized at the phosphorus side arm, PNN = (2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine) (Science 2009, 324, 74). In the initial thermal reaction, the coordination of a water molecule is followed by cleavage of an O-H bond and aromatization of the PNN ligand to form (PNN)RuH(CO)(OH) (3'), the most stable complex in the reaction. This low-barrier step is followed by the rate-determining dearomatization and formation of H(2). Next, a second water molecule is activated, resulting in the formation of the cis-dihydroxo complex (PNN)Ru(CO)(OH)(2) (7), which photolytically eliminates H(2)O(2). Time-dependent DFT calculations predict that the breaking of the two strong Ru-O bonds and the formation of the O-O bond in this photolytic reaction involve low-energy triplet states and singlet-triplet crossings. Rather than regeneration of initial complex 1 after the light-induced H(2)O(2) evolution in the catalytic cycle, the DFT calculations predict a new route with a lower energy barrier via the regeneration of 1', an isomer of 1 with the unsaturated carbon at the nitrogen side arm of the PNN ligand. This new route involves hydride transfer from the methylene group at the nitrogen side, rather than the previously proposed regeneration of 1 through hydride transfer from the phosphorus side arm of the PNN ligand.
General method for site-directed mutagenesis in Escherichia coli O18ac:K1:H7: deletion of the inducible superoxide dismutase gene, sodA, does not diminish bacteremia in neonatal rats (1989)

A defined deletion in the Escherichia coli K-12 sodA gene (encoding manganese-superoxide dismutase) linked to a nontransposable selectable marker was generated by transposon Tn5 insertion in combination with in vitro mutagenesis. This mutant allele was used to replace the wild-type sodA gene in an E. coli clinical isolate of serotype O18ac:K1:H7 by bacteriophage P1 transduction. The O18ac:K1:H7 sodA mutant contained no manganese-superoxide dismutase and no hybrid manganese-iron-superoxide dismutase. The sodA mutant was more sensitive to paraquat toxicity than were the parental strain and an isogenic mutant bearing an analogously constructed sodA+ Tn5 insertion allele. In a suckling rat model for bacteremia following oral inoculation of E. coli K1, the sodA mutant was undiminished in its capabilities both to colonize the gastrointestinal tract and, surprisingly, to cause bacteremia. In conjunction with the rat model for E. coli K1 pathogenesis, the method for site-directed mutagenesis described in this paper permits determination of the role played in colonization and bacteremia by any K1 gene which either has a homolog in E. coli K-12 or can be cloned and manipulated therein.
Visualization of Metadata (1999)

Many cases of NAT in the pediatric population are initially missed. Orthopedic providers must maintain a high index of suspicion for NAT as many of these patients will present with musculoskeletal injuries. The authors report a rare case of NAT in a male child resulting in bilateral femoral diaphyseal fractures. The patient was successfully treated through Pavlik harness placement. Orthopedic providers should consider Pavlik harness placement as a viable option even for young children >6 months of age presenting with femoral shaft fractures if spica casting or open reduction internal fixation is not appropriate.
In vitro Evaluation of the Antimicrobial Efficacy and Biocompatibility of a Silver-Coated Central Venous Catheter (1994)

Central venous catheter infection presents an important problem in modern medicine, leading sometimes to a life-threatening situation for the patient as well as contributing to prolonged hospital stay and to an increase in costs. We have evaluated the in vitro biocompatibility and antimicrobial activity of a silver-coated polyurethane catheter designed for use as a colonization-resistant, antiinfective catheter. Due to a comparatively low silver release, the catheter performed well in cell toxicity and blood compatibility tests as well as in acute toxicity tests done with mice. The antimicrobial activity was tested in stationary and dynamic bacterial adherence experiments using S. epidermidis, E. coli and P. aeruginosa as test strains. The silver-coated polyurethane catheter showed good ability to prevent microbial colonization of the catheter surface. Currently a clinical trial of the silver-coated catheter is under investigation.
Color-coded visualization of magnetic resonance imaging multiparametric maps (2017)

Multiparametric magnetic resonance imaging (mpMRI) data are emergingly used in the clinic e.g. for the diagnosis of prostate cancer. In contrast to conventional MR imaging data, multiparametric data typically include functional measurements such as diffusion and perfusion imaging sequences. Conventionally, these measurements are visualized with a one-dimensional color scale, allowing only for one-dimensional information to be encoded. Yet, human perception places visual information in a three-dimensional color space. In theory, each dimension of this space can be utilized to encode visual information. We addressed this issue and developed a new method for tri-variate color-coded visualization of mpMRI data sets. We showed the usefulness of our method in a preclinical and in a clinical setting: In imaging data of a rat model of acute kidney injury, the method yielded characteristic visual patterns. In a clinical data set of N = 13 prostate cancer mpMRI data, we assessed diagnostic performance in a blinded study with N = 5 observers. Compared to conventional radiological evaluation, color-coded visualization was comparable in terms of positive and negative predictive values. Thus, we showed that human observers can successfully make use of the novel method. This method can be broadly applied to visualize different types of multivariate MRI data.
Description of two hardware convolvers as a part of a general image computer (1981)

The extensive use of images in decision processes makes it necessary to develop new approaches in handling this amount of data. For that purpose, several image computers have been built, among which the UPIC (Universal Picture Computer) was realized at the University of Leuven. In the UPIC , computing power has been decentralized to several modules, each of them performing a single image operation. Convolution can be carried out making use of two alternative methods, which are both described.-from Authors
High‐performance liquid chromatographic enantioseparation of (<i>RS</i>)‐bupropion using isothiocyanate‐based chiral derivatizing reagents (2013)

A high-performance liquid chromatographic (HPLC) method for enantioseparation of bupropion was developed using two isothiocyanate-based chiral derivatizing reagents, (S)-1-(1-naphthyl) ethyl isothiocyanate, (S)-NEIT, and (R)-α-methyl benzyl isothiocyanate, (R)-MBIT. The diastereomers synthesized with (S)-NEIT were enantioseparated by reversed-phase HPLC using gradient elution with mobile phase containing water and acetonitrile, whereas diastereomers synthesized with (R)-MBIT were enantioseparated using triethyl amine phosphate buffer and methanol. Derivatization conditions were optimized and the method was validated for accuracy, precision and limit of detection. The limit of detection was found to be 0.040-0.043 µg/mL for each of the diastereomers prepared with (S)-NEIT.
The design and use of a 2 terabyte optical archival store (1988)

A two-terabyte optical archival store (OAS) has been built and is currently in use with a number of VAX computers. It is intended to hold very large sets of experimental data for a minimum cost, with automatic operation and rapid random access to files. The system has been designed for easy use by scientists. The OAS can be used from a VAX cluster or via an extensive Ethernet and has shown the strong reliability needed for holding valuable data for long periods of time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Unsupervised Monocular Depth Estimation Based on Residual Neural Network of Coarse–Refined Feature Extractions for Drone (2019)

To take full advantage of the information of images captured by drones and given that most existing monocular depth estimation methods based on supervised learning require vast quantities of corresponding ground truth depth data for training, the model of unsupervised monocular depth estimation based on residual neural network of coarse–refined feature extractions for drone is therefore proposed. As a virtual camera is introduced through a deep residual convolution neural network based on coarse–refined feature extractions inspired by the principle of binocular depth estimation, the unsupervised monocular depth estimation has become an image reconstruction problem. To improve the performance of our model for monocular depth estimation, the following innovations are proposed. First, the pyramid processing for input image is proposed to build the topological relationship between the resolution of input image and the depth of input image, which can improve the sensitivity of depth information from a single image and reduce the impact of input image resolution on depth estimation. Second, the residual neural network of coarse–refined feature extractions for corresponding image reconstruction is designed to improve the accuracy of feature extraction and solve the contradiction between the calculation time and the numbers of network layers. In addition, to predict high detail output depth maps, the long skip connections between corresponding layers in the neural network of coarse feature extractions and deconvolution neural network of refined feature extractions are designed. Third, the loss of corresponding image reconstruction based on the structural similarity index (SSIM), the loss of approximate disparity smoothness and the loss of depth map are united as a novel training loss to better train our model. The experimental results show that our model has superior performance on the KITTI dataset composed by corresponding left view and right view and Make3D dataset composed by image and corresponding ground truth depth map compared to the state-of-the-art monocular depth estimation methods and basically meet the requirements for depth information of images captured by drones when our model is trained on KITTI.
THE HISTORY OF EARTHQUAKE DAMAGE OF THE EAST PAGODA IN YAKUSHI-JI TEMPLE (2010)

In this study,we treated the history of earthquake damage of the east pagoda in the Yakushi-ji temple, built about 1300 years ago.We estimated the peak ground acceleration at the Yakushi-ji temple of historical earthquakes which have damaged this building, and compare this result with old documents about earthquake damage of this building. The east pagoda has damaged several times not only by crustal earthquakes with short source distance, but also by inter-plate earthquakes with long source distance, and especially Shin-hashira, which is pillar built in the center of this pagoda, was damaged frequently.We examined about the damage by Ansei Nara earthquake (1854) and the restoration by reading the diary written by secretary of the Yakushi-ji temple.At this earthquake,Shin-hashira as well as the upper story of this pagoda inclined due to the lack of maintenance.
On motion sensors as source for user input inference in smartphones (2015)

A wealth of sensors on smartphone has greatly enriched people's life, but these sensors also brought potential security problems since they allow third-party applications to monitor the motion changes of smartphones. This paper presents an empirical study of analyzing the characteristics of accelerometer and magnetometer data collected from third-party applications to infer user inputs on smartphone. Specifically, an installed application was run as a background process to monitor the data of motion sensors. Accelerometer data was analyzed to detect the occurrence of touch tap actions. Then the accelerometer data and magnetometer data were combined together to build a model for inferring the tap position on touchscreen. Along with common layouts of keyboard or number pad, one can easily obtain users' inputs. Results indicated that users' inputs could be accurately inferred from the data of motion sensors, with the accuracies of 100% and 80% for tap-action detection and input inference in some cases. We conclude that readings from motion sensor are a powerful side channel for inferring user inputs, and could provide extra avenues for attackers.
The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. (1988)

The heterogeneous nuclear ribonucleoprotein C1 and C2 proteins were preferentially cross-linked by treatment with UV light in nuclear extracts to RNAs containing six different polyadenylation signals. The domain required for the interaction was located downstream of the poly(A) cleavage site, since deletion of this segment from several polyadenylation substrate RNAs greatly reduced cross-linking efficiency. In addition, RNAs containing only downstream sequences were efficiently cross-linked to C proteins, while fully processed, polyadenylated RNAs were not. Analysis of mutated variants of the simian virus 40 late polyadenylation signal showed that uridylate-rich sequences located in the region between 30 and 55 nucleotides downstream of the cleavage site were required for efficient cross-linking of C proteins. This downstream domain of the simian virus 40 late poly(A) addition signal has been shown to influence the efficiency of the polyadenylation reaction. However, there was not a strict correlation between cross-linking of C proteins and the efficiency of polyadenylation.
Ultraviolet generation with passively Q-switched microchip lasers (1996)

First, second, third, fourth, and f ifth harmonics of the output of a f iber-pumped passively Q-switched Nd:YAG microchip laser have been obtained at pulse energies of 8.0, 3.5, 0.3, 0.7, and 0.01 microJ, respectively, in an optical head occupying a volume of less than 3 cm(3). This compact, economical all-solid-state source provides coherent subnanosecond multikilowatt infrared, visible, and ultraviolet pulses at repetition rates in excess of 10 kHz.
Synthesis and biological properties of 1-oxapenems. (1990)

Several 2-substituted oxapenems, 1a, 1b and 1c, bearing the hydroxyethyl side-chain at 6 alpha were synthesized in a highly stereoselective manner starting from the commercially available 3 alpha-hydroxyethyl-4 beta-acetoxyazetidinone (5). The stability, in vitro antibacterial activity, and beta-lactamase inhibitory properties of these oxapenems were examined. The 2-isopropyl penem 1c had considerable stability as shown by its t1/2 of 200 minutes in pH 7.0 buffer solution and at 37 degrees C, while the other two 1a and 1b were labile. Interestingly, the antibacterial activity of these compounds paralleled their stability and thus penem 1c showed appreciable MICs, whereas the other two were virtually inactive. All three penems inhibited certain cephalosporinases strongly, but penicillinases only weakly. Thus, the inhibitory spectrum was similar to that for epi-thienamycin B and not the spectrum for clavulanic acid.
PHENOTYPIC EXPRESSIONS OF THE MAJOR HISTOCOMPATIBILITY LOCUS IN MAN (<i>HL-A</i>): LEUKOCYTE ANTIGENS AND MIXED LEUKOCYTE CULTURE REACTIVITY (1968)

The evidence is reviewed that a single genetic system, the major histocompatibility locus in man, HL-A, determines most of the antigens measured by presently available leukocyte isoantisera, and also controls reactivity in one-way mixed leucocyte culture tests. Studies in 12 families are presented to support this conclusion. Some interesting exceptions to the general typing-MLC tests correlation are presented and discussed.