gebhart/patrepeval huggingface dataset:
Effects of Prostaglandin Analogues on Human Ciliary Muscle and Trabecular Meshwork Cells (2003)

Both analogues changed gene expression similarly in either HCM or HTM cells, but the changes appeared to be cell specific, perhaps indicating that other transcription factors are influential. Outflow of aqueous humor may be increased by the prostaglandin analogues by alterations in the extracellular matrix. Other changes may influence cellular metabolism, such as the increases in IGF1, tumor necrosis factor superfamily-10 and promelanosome-concentrating hormone.
Increasing the accuracy of untaught robot positions by means of a multi-camera system (2010)

We aim to improve the absolute in line positional accuracy of a robot-guided effector to better than 1 mm. We do so using photogrammetric techniques and by relying heavily on simulations to fine tune each parameter and avoid weak configurations. We also use simulations to design an LED calibration object adapted to this application. A test procedure enables us to validate both the simulated results as well as the calibration procedure. The test results exceed expectations by improving the absolute positioning of a robot effector by a factor of 20.
Collusion-Traceable Secure Multimedia Distribution Based on Controllable Modulation (2008)

In this paper, a secure multimedia distribution scheme resistant to collusion attacks is proposed. In this scheme, the multimedia content is modulated by <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</i> pseudorandom sequences at the server side, which generates the unintelligible multimedia content, and then demodulated under the control of the fingerprint code at the customer side, which produces the multimedia content contains a unique code. The demodulation process adopts collusion-resistant fingerprint codes to determine which sequences will be removed from the received multimedia content. Since the collusion-resistant fingerprint code is used, the colluders who combine different copies together can be detected. Compared with existing schemes, the collusion-resistant code is used in the proposed scheme, which confirms the robustness against collusion attacks. This scheme provides a good choice for secure multimedia content distribution.
Moment tensor solutions for small and moderate earthquakes in the Ibero‐Maghreb region (2003)

We applied time domain moment tensor inversion of local and regional waveforms to small and moderate ( M w = 3.5–5.7) shallow earthquakes from the Iberian Peninsula, northern Morocco, and northern Algeria. For the 6+ years period from November 1995 to March 2002 and the previous Network of Autonomously Recording Seismograms (NARS) experiment, moment tensor solutions were obtained for 58 events, considerably increasing the total number of available solutions in the study area. For each event we performed a moment tensor inversion and a double‐couple grid search. For simple faulting events the grid search is valuable as a quality test for its ability to reveal potential ambiguities of the solutions and to assess confidence limits of fault plane parameters or principal axes orientation. The computed mechanisms show regional consistency: A large part of the Iberian Peninsula is characterized by normal faulting mechanisms with SW‐NE oriented T axes. Thrusting and SE‐NW compression is dominant in Algeria. In the Alboran Sea, the westernmost part of the Mediterranean, and the transition between both regimes, strike‐slip mechanisms dominate with approximately N‐S oriented P axes. This pattern suggests a regional anomaly characterized by clockwise rotation of the principal horizontal stress orientations.
A triplet spike-timing–dependent plasticity model generalizes the Bienenstock–Cooper–Munro rule to higher-order spatiotemporal correlations (2011)

Synaptic strength depresses for low and potentiates for high activation of the postsynaptic neuron. This feature is a key property of the Bienenstock-Cooper-Munro (BCM) synaptic learning rule, which has been shown to maximize the selectivity of the postsynaptic neuron, and thereby offers a possible explanation for experience-dependent cortical plasticity such as orientation selectivity. However, the BCM framework is rate-based and a significant amount of recent work has shown that synaptic plasticity also depends on the precise timing of presynaptic and postsynaptic spikes. Here we consider a triplet model of spike-timing-dependent plasticity (STDP) that depends on the interactions of three precisely timed spikes. Triplet STDP has been shown to describe plasticity experiments that the classical STDP rule, based on pairs of spikes, has failed to capture. In the case of rate-based patterns, we show a tight correspondence between the triplet STDP rule and the BCM rule. We analytically demonstrate the selectivity property of the triplet STDP rule for orthogonal inputs and perform numerical simulations for nonorthogonal inputs. Moreover, in contrast to BCM, we show that triplet STDP can also induce selectivity for input patterns consisting of higher-order spatiotemporal correlations, which exist in natural stimuli and have been measured in the brain. We show that this sensitivity to higher-order correlations can be used to develop direction and speed selectivity.
Control of solid state laser dynamics by semiconductor devices (1995)

We have successfully demonstrated that an appropriately designed semiconductor saturable absorber device, the antiresonant Fabry-Perot saturable absorber, can reliably start and sustain stable mode locking of solid state lasers such as Nd:YAG, Nd:YLF, Nd:Glass, Cr:LiSAF, and Ti:sapphire lasers. Especially for solid state lasers with long upper-state lifetimes, previous attempts to produce self-starting passive mode locking with saturable absorbers was always accompanied by self-<i>Q</i>-switching. We derive criteria that characterize the dynamic behavior of solid state lasers in the important regimes of <i>Q</i>-switching, mode-locked <i>Q</i>-switching, and continuous-wave mode locking in the picosecond and femtosecond range for the pulsewidth. We demonstrate that semiconductor absorbers can be designed to predetermine the dynamic behavior of a laser for a given solid state laser material and present an experimental verification. This allows for the development and design of robust, compact pico- and femtosecond solid state laser sources for scientific and industrial applications.
CCCIX.—Substitution products of 4-nitro- and 4-acetamido-diphenyl ether (1929)

H. A. Scarborough, J. Chem. Soc., 1929, 2361 DOI: 10.1039/JR9290002361
1,25-Dihydroxyvitamin D3 Enhances the Apoptotic Activity of MDM2 Antagonist Nutlin-3a in Acute Myeloid Leukemia Cells Expressing Wild-type p53 (2010)

The tumor suppressor p53 is often referred to as "the guardian of the genome" because of its central role in the cellular response to oncogenic stress and prevention of tumor development. Mutations of p53 in acute myeloid leukemia (AML) are rare but resistance to chemotherapy has been reported because of the deregulation of the p53 signaling and differentiation pathways. It is known that the interaction of the vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25D) with its functional vitamin D receptor leads to differentiation, G(1) arrest, and increased cell survival in p53-null AML cells. However, there are no reports on the effect of 1,25D in leukemia cells expressing wild-type p53. Here, we examine vitamin D signaling in AML cells MOLM-13 and OCI-AML3 expressing wild-type p53 in the presence and absence of the MDM2 antagonist nutlin-3. We find that 1,25D alone induces monocytic differentiation in these cell lines similar to that seen in p53-null AML cells, suggesting that the presence of wild-type p53 is compatible with activation of vitamin D signaling. Combination of nutlin-3a with 1,25D accelerated programmed cell death, likely because of enhanced nutlin-induced upregulation of the proapoptotic PIG-6 protein and downregulation of antiapoptotic BCL-2, MDMX, human kinase suppressor of Ras 2, and phosphorylated extracellular signal-regulated kinase 2.
Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database (2002)

No evidence was found that children with autism were more likely than children without autism to have had defined gastrointestinal disorders at any time before their diagnosis of autism.
Sm/sub 2/(Co,Fe,Cu,Zr)/sub 17/ magnets with higher Fe content (1989)

The magnetic properties of Sm/sub 2/(Co,Fe,Cu,Zr)/sub 17/ magnets were improved by increasing the Fe content without raising the Zr content. With increasing Fe content, the remanence rises monotonically while the intrinsic coercive force drops sharply for 0.27<v<0.29 and then increases for 0.30<v<0.33 in Sm(Co/sub bal/Fe/sub v/Cu/sub 0.056/Zr/sub 0.02/)/sub 7.546/. For the nominal composition Sm(Co/sub 0.612/Fe/sub 0.316/Cu/sub 0.052/Zr/sub 0.02/)/sub 7.73/, most magnets developed (BH)/sub max/=31-33 MGOe while some reached 33-34 MGOe. Still higher Fe contents may result in further improvement of Sm/sub 2/TM/sub 17/ magnets.<<ETX>>
NASA/MSFC prediction techniques (1987)

The NASA/MSFC method of forecasting is more formal than NOAA's. The data is smoothed by the Lagrangian method and linear regression prediction techniques are used. The solar activity period is fixed at 11 years--the mean period of all previous cycles. Interestingly, the present prediction for the time of the next solar minimum is February or March of 1987, which, within the uncertainties of two methods, can be taken to be the same as the NOAA result.
Rapid isolation of mycoviral double-stranded RNA from Botrytis cinerea and Saccharomyces cerevisiae (2011)

The method yields high quality dsRNA, free from DNA and ssRNA. The use of nucleases to degrade the DNA or the ssRNA is not required, and it can be used to isolate dsRNA from any type of fungi or any biological sample that contains dsRNA.
Surveillance of feral cats for influenza A virus in North Central Florida (2011)

No virus was isolated from any of 927 cats examined using MDCK cell or embryonated chicken egg culture methods, nor was viral RNA detected by RT-PCR in 200 samples tested. However, 0.43% of cats tested antibody positive for influenza A by commercial ELISA. These results suggest feral cats in this region are at minimal risk for influenza A virus infection.
Expression of Somatomedin/Insulin-Like Growth Factor Messenger Ribonucleic Acids in the Human Fetus: Identification, Characterization, and Tissue Distribution* (1988)

Several lines of evidence indicate that multiple human fetal tissues synthesize somatomedins/insulin-like growth factors (Sm/IGFs). To investigate the synthesis of Sm/IGFs in vivo, we isolated polyadenylated RNAs from multiple human fetal tissues of 16-20 weeks gestation and performed Northern and dot-blot analyses using 32P-labeled cDNAs and oligodeoxyribonucleotide (oligomer) probes complementary to human Sm-C/IGF-I and IGF-II mRNAs. Sm-C/IGF-I mRNAs were present in all tissues studied. IGF-II mRNAs were detectable in all tissues except the cerebral cortex and hypothalamus. IGF-II mRNA levels were consistently higher than Sm-C/IGF-I mRNAs in all tissues where IGF-II mRNAs were detectable (varying from 2-fold higher in spleen and thymus to 650-fold higher in liver), suggesting that IGF-II is synthesized in greater quantities than Sm-C/IGF-I in most tissues during early fetal life. Liver, adrenal, and skeletal muscle had the highest levels of IGF-II mRNAs, while placenta and stomach had the highest level of Sm-C/IGF-I mRNAs. Multiple Sm-C/IGF-I and IGF-II transcripts were identified with estimated sizes 0.7, 5.3, and 8.0 kilobases (kb) for Sm-C/IGF-I and 1.8, 2.0, 2.8, 3.0, 4.0, 4.8, and 6.2 kb for IGF-II. The 5.3-kb species was the most abundant Sm-C/IGF-I mRNA. The largest Sm-C/IGF-I transcript (8.0 kb) was identified in the intestine, muscle, kidney, placenta, stomach, heart, skin, pancreas, hypothalamus, and brain stem and was most abundant in the hypothalamus and muscle. The smallest transcript (0.7 kb) was detectable only in spleen, adrenal, placenta, and stomach. On the other hand, nearly all species of IGF-II mRNAs were found in tissues with detectable mRNAs, with the 6.2-kb mRNA being the most abundant. The variation in abundance and species of Sm-C/IGF-I and IGF-II mRNAs among different human fetal tissues suggests tissue-specific differences in Sm-C/IGF-I and IGF-II gene expression, mRNA precursor processing, and/or mRNA stability. Such differences may have significance for the roles of Sm-C/IGF-I and IGF-II during human fetal development. The finding of Sm/IGF mRNAs in many human fetal tissues also supports a local role for Sm/IGFs in human fetal development.
PDGF Receptor-α Does Not Promote HCMV Entry into Epithelial and Endothelial Cells but Increased Quantities Stimulate Entry by an Abnormal Pathway (2012)

Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor-α (PDGFRα) were reported to mediate entry of HCMV, including HCMV lab strain AD169. AD169 cannot assemble gH/gL/UL128-131, a glycoprotein complex that is essential for HCMV entry into biologically important epithelial cells, endothelial cells, and monocyte-macrophages. Given this, it appeared incongruous that EGFR and PDGFRα play widespread roles in HCMV entry. Thus, we investigated whether PDGFRα and EGFR could promote entry of wild type HCMV strain TR. EGFR did not promote HCMV entry into any cell type. PDGFRα-transduction of epithelial and endothelial cells and several non-permissive cells markedly enhanced HCMV TR entry and surprisingly, promoted entry of HCMV mutants lacking gH/gL/UL128-131 into epithelial and endothelial cells. Entry of HCMV was not blocked by a panel of PDGFRα antibodies or the PDGFR ligand in fibroblasts, epithelial, or endothelial cells or by shRNA silencing of PDGFRα in epithelial cells. Moreover, HCMV glycoprotein induced cell-cell fusion was not increased when PDGFRα was expressed in cells. Together these results suggested that HCMV does not interact directly with PDGFRα. Instead, the enhanced entry produced by PDGFRα resulted from a novel entry pathway involving clathrin-independent, dynamin-dependent endocytosis of HCMV followed by low pH-independent fusion. When PDGFRα was expressed in cells, an HCMV lab strain escaped endosomes and tegument proteins reached the nucleus, but without PDGFRα virions were degraded. By contrast, wild type HCMV uses another pathway to enter epithelial cells involving macropinocytosis and low pH-dependent fusion, a pathway that lab strains (lacking gH/gL/UL128-131) cannot follow. Thus, PDGFRα does not act as a receptor for HCMV but increased PDGFRα alters cells, facilitating virus entry by an abnormal pathway. Given that PDGFRα increased infection of some cells to 90%, PDGFRα may be very useful in overcoming inefficient HCMV entry (even of lab strains) into the many difficult-to-infect cell types.
The Immune Response in Adenoids and Tonsils (2000)

The adenoid and tonsils are lymphoid tissues located in the pharynx that play an important role in host defense against invading antigens of the upper respiratory tract. Histologically, these structures consist of four well-defined microcompartments which all participate in the immune response: the cryptepithelium, the follicular germinal center with the mantle zone and interfollicular area. With the uptake of antigen by M-cells present in the cryptepithelium a process is initiated which ultimately results in the generation and dissemination of antigen-specific memory and mainly dimeric IgA-producing effector B-lymphocytes. This process requires successful cognate interactions between antigen-presenting cells and lymphocytes and mutually between lymphocytes, which depend not only on antigen-specific signals but also on the expression of various complementary adhesion and costimulatory molecules.
A Review on Gravity Power Generation (2014)

Conserving energy has become the biggest issue in present scenario. Due to the development and modernization the electricity demand is increasing at high extent. To fulfil this demand globally which is without any harmful effect on environment is possible by using gravity power generation. The reason behind generating power by using gravity is that it is available all over the earth. Comparing to the other sources like chemical, thermal and other sources gravity is weak, is scalable. This weakness is due to uniformity, or steady state of our interactions with gravity. As gravity is weak as compared to the other sources, it cannot be efficiently converted into electrical energy or in the other form. The concept of gravity power generation is simple. The basic concept of gravity power generation mechanism is, when a body moves down from higher altitude to lower one its potential energy is converted into kinetic energy. This motion is converted into circular motion and that circular motion is converted into electricity by using a Mini DC generator.
Effects of solvents on electrospun polymeric fibers: preliminary study on polystyrene (2004)

Abstract Six solvents [acetic acid, acetonitrile, m ‐cresol, toluene, tetrahydrofuran (THF) and dimethylformamide (DMF)] with different properties (eg density, boiling point, solubility parameter, dipole moment and dielectric constant) were used to prepare electrospun polystyrene (PS) fibers. Fiber diameters were found to decrease with increasing density and boiling point of the solvents. A large difference between the solubility parameters of PS and the solvent was responsible for the bead‐on‐string morphology observed. Productivity of the fibers (the numbers of fiber webs per unit area per unit time) increased with increasing dielectric constant and dipole moment of the solvents. Among the solvents studied, DMF was the best solvent that provided PS fibers with highest productivity and optimal morphological characteristics. The beadless, well‐aligned PS fibers with a diameter of ca 0.7 µm were produced from the solution of 10 % (w/v) of PS in DMF at an applied electrostatic field of 15 kV/10 cm, a nitrogen flow rate of 101 ml min −1 and a rotational speed of the collector of 1500 rev min −1 . Copyright © 2004 Society of Chemical Industry
Teratogenic effects of methamphetamine in mice and rabbits (1971)

Abstract Pregnant CFI mice and New Zealand White rabbits were given methamphetamine hydrochloride intravenously during days 9–15 and 12–30 of gestation, respectively. Offspring of mice given 5.0 mg/kg on days 9–15 of gestation had less than 2% anomalies. When 10.0 mg/kg were given on days 9–15, a 13.6% incidence of anomalies was observed. Offspring of rabbits receiving 1.5 mg/kg of methamphetamine on days 12–15, 15–20, and 12–30 of gestation showed an incidence of fetal anomalies of 12, 4, and 15.5% respectively. Offspring sired by treated males showed no significant weight change and had no increased anomaly rate.
Dreams of Precision Manufacturing: Beavers Dental of Morrisburg, Ontario (2009)

In 1946 George Beavers went to Germany and convinced Rudolf Funke to bring his superior dental bur technology to Canada. What resulted in Beaver's small factory in Morrisburg, Ontario was an amalgam of European and North American manufacturing technologies. This has enabled Beavers Dental to become the world's largest producer of dental burs.
Combining Shape-Changing Interfaces and Spatial Augmented Reality Enables Extended Object Appearance (2016)

We propose combining shape-changing interfaces and spatial augmented reality for extending the space of appearances and interactions of actuated interfaces. While shape-changing interfaces can dynamically alter the physical appearance of objects, the integration of spatial augmented reality additionally allows for dynamically changing objects' optical appearance with high detail. This way, devices can render currently challenging features such as high frequency texture or fast motion. We frame this combination in the context of computer graphics with analogies to established techniques for increasing the realism of 3D objects such as bump mapping. This extensible framework helps us identify challenges of the two techniques and benefits of their combination. We utilize our prototype shape-changing device enriched with spatial augmented reality through projection mapping to demonstrate the concept. We present a novel mechanical distance-fields algorithm for real-time fitting of mechanically constrained shape-changing devices to arbitrary 3D graphics. Furthermore, we present a technique for increasing effective screen real estate for spatial augmented reality through view-dependent shape change.
Urban distribution of Phlebotominae in a cutaneous leishmaniasis focus, Argentina (2008)

Urbanization and vector domestication are currently proposed as factors that contributed to the recent increase of American cutaneous leishmaniasis (ACL). Is likely also urban transmission? Oran is the main city in the Argentinean hyper-endemic area of ACL, and human cases in urban residences are usually reported. In order to assess the spatial distribution of risk, phlebotomine traps were located in different environments of Oran. A total of 7,787 sand flies were captured: Lutzomyia neivai (98.1%), Lutzomyia migonei (1.2%), Lutzomyia cortelezzii (0.7%), and one Lutzomyia shannoni. During the season of transmission (April-May) a single sand fly was obtained in one out of five urban sites, while a trap in a peri-urban pigsty captured up to 2,985 Lu. neivai/night. Captures performed in the other season of vector activity (September-October) revealed that small-scale changes in the pigsty environment resulted in noticeable changes in the abundance of Lu. neivai. In addition, in a new neighbourhood, on the fringe of the city, 1,073 Lu. neivai/site were captured in the forested edge but one in the yard of the houses. Therefore, in this urban ACL focus the human-vector effective contact risk is still associated with peri-urban vegetation and ecotone modifications despite the urban residence of the cases.
Field and Impedance of an Oscillating Sphere in a Viscoelastic Medium with an Application to Biophysics (1951)

With an application to human tissue in view, a theoretical analysis of the behavior of mechanical vibrations in a medium with elastic, viscous, and relaxational properties is made. For this purpose, the equations of wave motion in a viscoelastic medium are discussed in general and solved for two problems, which are significant for the propagation and the transfer of vibrational energy: (1) energy propagation and absorption in plane waves, (2) field and impedance of an oscillating sphere. The results show that the energy is propagated in two kinds of waves, the relative intensities of which change strongly with frequency: transverse waves, owing to the shear elasticity and viscosity, and compression (acoustical) waves, owing to the volume compressibility of the medium. A more detailed treatment is then accomplished for human muscle tissue by inserting the approximate values of its elastic constants into the general formulas, thus explaining the behavior in a frequency range from 0 up to several hundred kc.