gebhart/patrepeval huggingface dataset:
Human Flicker Fusion Correlates With Physiological Measures of Magnocellular Neural Efficiency (2018)

The rapidity with which the visual system can recover from stimulation in order to respond again has important implications for efficiently processing environmental stimuli in real time. To date, there has been little integration of the human psychophysical and physiological research underlying the neural mechanisms contributing to temporal limits on human visual perception. Hence, we investigated the relationship between achromatic flicker fusion frequency and temporal analysis of the magnocellular (M) and parvocellular (P) contributions to the achromatic non-linear multifocal Visual Evoked Potential (mfVEP) responses recorded from occipital scalp (Oz). It was hypothesized, on the basis of higher temporal cut-off frequencies reported for primate M vs. P neurons, that sinusoidal flicker fusion frequencies would negatively correlate with the amplitude of M- but not P-generated non-linearities of the mfVEP. This hypothesis was borne out in 72 typically developing young adults using a four-way forced choice sinusoidal flicker fusion task: amplitudes of all non-linearities that demonstrated a clear M-generated component correlated negatively with flicker thresholds. The strongest of these correlations were demonstrated by the main M non-linearity component (K2.1<sub>N70-P100</sub>) for both high contrast (<i>r</i> = -0.415, <i>n</i> = 64, <i>p</i> < 0.0005) and low contrast (<i>r</i> = -0.345 <i>n</i> = 63, <i>p</i> < 0.002) conditions, indicating that higher achromatic flicker fusion threshold is linked to a more efficient (smaller second order kernels) M system. None of the peaks related to P activity showed significant correlations. These results establish flicker thresholds as a functional correlate of M-pathway function as can be observed in the non-linear analysis of mfVEP.
A new screening test for antimitotic compounds using the universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates. (1992)

A universal intracellular factor, the "M phase-Promoting Factor" (MPF), triggers the G2/M transition of the cell cycle in all organisms. This factor displays an easily assayable histone H1 kinase (H1K) activity and is composed of at least two subunits, p34cdc2 (catalytic) and cyclin Bcdc13 (regulatory). We describe here a microtitration plate assay using affinity-immobilized H1K-MPF as a cell cycle-specific target to screen for antimitotic compounds. First, meiotic starfish oocytes were selected as the most convenient and abundant source of M phase extracts containing high levels of H1K. Second, we used the strong and specific interaction between p34cdc2 and p13suc1 to affinity-immobilize H1K-MPF on p13suc1-coated microtitration plates. p13suc1-coated wells specifically retain the M phase kinase, the activity of which is assayed with histone H1 and gamma-32P-ATP. Among 10 microtitration plates, Maxisorp plates (Nunc) proved to be the most efficient at retaining H1K through p13suc1. Experimental conditions to coat the plates with p13suc1, to immobilize and to measure p34cdc2/cyclin Bcdc13 kinase activity, as well as to store p13suc1-precoated plates, have been optimized. Using this system we tested 18 currently used anticancer drugs and S or G2 inhibitors; none of them displayed any inhibitory activity. The microtitration assay has allowed the detection of two H1K inhibitors, isopentenyladenine (I50: 40 microM) and staurosporine (I50: 3.2 nM). This affinity-immobilized H1K-MPF can thus now be used as a simple screening system to detect inhibitors of a major cell cycle-regulating component. This method may prove useful to screen for antimitotic compounds of potential anticancer interest.
Folded U-shaped micro-wire technology for GaAs IC interconnections (2003)

A novel microwire structure with folded U-shape cross section has been developed for application in GaAs IC interconnections. The structure enhances the mechanical strength and makes it possible to form an air-bridge with a 3-mm-long reach. Evaluations of the high-frequency characteristics of the wire in a transmission line reveal that this technology can be applied in microwave circuits. This technology makes it possible to transmit a microwave efficiently with a miniaturized coplanar type transmission line. This technology should prove very attractive for developing high-speed GaAs LSIs and compact monolithic microwave integrated circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
46.2: System Architecture and FPGA‐Implementation of the SSC Local Dimming Processor for an Edge‐Lit Serial TV (2011)

Abstract We present an efficient hardware implementation of our local dimming processor which consists of a preprocessor (Condenser), the Sorted Sector Covering (SSC) algorithm and a postprocessor (Pixel Compensation) in a low‐cost FPGA. The system runs in a typical 40″ Full‐HD TV set with edge‐ LED. An equivalent visual quality like the undimmed version has been achieved, while the power consumption for the BLU with four LED units is reduced by 21%. In case of tolerating limited clipping artifacts, the power consumption can even be reduced by 46%.
Chemopreventive Effects of Pomegranate Seed Oil on Skin Tumor Development in CD <sub>1</sub> Mice (2003)

Pomegranate seed oil was investigated for possible skin cancer chemopreventive efficacy in mice. In the main experiment, two groups consisting each of 30, 4-5-week-old, female CD(1) mice were used. Both groups had skin cancer initiated with an initial topical exposure of 7,12-dimethylbenzanthracene and with biweekly promotion using 12-O-tetradecanoylphorbol 13-acetate (TPA). The experimental group was pretreated with 5% pomegranate seed oil prior to each TPA application. Tumor incidence, the number of mice containing at least one tumor, was 100% and 93%, and multiplicity, the average number of tumors per mouse, was 20.8 and 16.3 per mouse after 20 weeks of promotion in the control and pomegranate seed oil-treated groups, respectively (P <.05). In a second experiment, two groups each consisting of three CD(1) mice were used to assess the effect of pomegranate seed oil on TPA-stimulated ornithine decarboxylase (ODC) activity, an important event in skin cancer promotion. Each group received a single topical application of TPA, with the experimental group receiving a topical treatment 1 h prior with 5% pomegranate seed oil. The mice were killed 5 h later, and ODC activity was assessed by radiometric method. The experimental group showed a 17% reduction in ODC activity. Pomegranate seed oil (5%) significantly decreased (P <.05) tumor incidence, multiplicity, and TPA-induced ODC activity. Overall, the results highlight the potential of pomegranate seed oil as a safe and effective chemopreventive agent against skin cancer.
Curcumin for Radiation Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Thirty Breast Cancer Patients (2013)

Radiation dermatitis occurs in approximately 95% of patients receiving radiotherapy (RT) for breast cancer. We conducted a randomized, double-blind, placebo-controlled clinical trial to assess the ability of curcumin to reduce radiation dermatitis severity in 30 breast cancer patients. Eligible patients were adult females with noninflammatory breast cancer or carcinoma in situ prescribed RT without concurrent chemotherapy. Randomized patients took 2.0 grams of curcumin or placebo orally three times per day (i.e., 6.0 grams daily) throughout their course of RT. Weekly assessments included Radiation Dermatitis Severity (RDS) score, presence of moist desquamation, redness measurement, McGill Pain Questionnaire-Short Form and Symptom Inventory questionnaire. The 30 evaluable patients were primarily white (90%) and had a mean age of 58.1 years. Standard pooled variances t test showed that curcumin reduced RDS at end of treatment compared to placebo (mean RDS = 2.6 vs. 3.4; P = 0.008). Fisher's exact test revealed that fewer curcumin-treated patients had moist desquamation (28.6% vs. 87.5%; P = 0.002). No significant differences were observed between arms for demographics, compliance, radiation skin dose, redness, pain or symptoms. In conclusion, oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients.
On GPU bus power reduction with 3D IC technologies (2014)

The complex buses consume significant power in graphics processing units (GPUs). In this paper, we demonstrate how the power consumption of buses in GPUs can be reduced with 3D IC technologies. Based on layout simulations, we found that partitioning and floorplanning of 3D ICs affect the power benefit amount, as well as the technology setup, target clock frequency, and circuit switching activity. For 3D IC technologies using two dies, we achieved the total power reductions of up to 21.5% over a baseline 2D design.
Dilithium initiators based on 1,3‐bis(1‐ phenylethenyl)benzene. Tetrahydrofuran and lithium <i>sec</i> ‐butoxide effects (1991)

Abstract The adduct (3) from 2 moles of sec ‐butyllithium with 1,3‐bis(1‐phenyl‐ethenyl)benzene has been prepared and evaluated as a hydrocarbon‐soluble, dilithium initiator for butadiene and styrene polymerization in cyclohexane or benzene solution. Under high vacuum conditions with purified reagents, bimodal molecular weight distributions are observed for polybutadienes with M n < 150 × 10 3 g/mol and for polystyrenes with M n < 50 × 10 3 g/mol; monomodal distributions are observed only for higher molecular weights. Addition of tetrahydrofuran ([THF]/[Li] = 14 to 32) or preformed lithium sec ‐butoxide ([LiOBu]/[3] = 1·1) produces narrow, monomodal molecular weight distributions even at M n = 26·2 × 10 3 g/mol polybutadiene and at M n = 10 × 10 3 g/mol for polystyrene. Added lithium sec ‐butoxide is the preferred additive since high 1,4‐polybutadienes are obtained. These results provide an explanation for the contradictory results reported previously; under less rigorous experimental conditions, oxygen and hydroxylic impurities can form lithium alkoxides in situ .
Isolation and Characterization of Streptomyces venezuelae Mutants Blocked in Chloramphenicol Biosynthesis (1985)

Twelve Streptomyces venezuelae mutants blocked in chloramphenicol biosynthesis were isolated. Two of these (Cm1-1 and Cm1-12) were apparently blocked in the conversion of chorismic acid to p-aminophenylalanine and three (Cm1-4, Cm1-5 and Cm1-8) accumulated p-aminophenylalanine and may have been blocked in the hydroxylation reaction that converted this intermediate to p-aminophenylserine. One mutant (Cm1-2) accumulated D-threo-1-p-nitrophenyl-2-propionamido-1,3-propanediol and D-threo-1-p-nitrophenyl-2-isobutyramido-1,3-propanediol, indicating that chlorination of the alpha-N-acyl group of chloramphenicol was blocked. The remaining six strains did not excrete any detectable chloramphenicol pathway intermediates.
Stem cell antigen‐1<sup>+</sup> cell‐based bone morphogenetic protein‐4 gene transfer strategy in mice failed to promote endosteal bone formation (2009)

Sca-1+ cell-based BMP4 ex vivo strategy did not promote robust endosteal bone formation, raising the possibility of intrinsic differences between FGF2- and BMP4-based strategies in their ability to promote endosteal bone formation. It emphasizes the importance of choosing an appropriate bone growth factor gene for delivery by this Sca-1+ cell-based ex vivo systemic gene transfer strategy to promote bone formation.
G-CSF Induces Membrane Expression of a Myeloperoxidase Glycovariant that Operates as an E-selectin Ligand on Human Myeloid Cells (2014)

The host defense response critically depends on the production of leukocytes by the marrow and the controlled delivery of these cells to relevant sites of inflammation/infection. The cytokine granulocyte-colony stimulating factor (G-CSF) is commonly used therapeutically to augment neutrophil recovery following chemo/radiation therapy for malignancy, thereby decreasing infection risk. Although best known as a potent inducer of myelopoiesis, we previously reported that G-CSF also promotes the delivery of leukocytes to sites of inflammation by stimulating expression of potent E-selectin ligands, including an uncharacterized ∼65-kDa glycoprotein. To identify this ligand, we performed integrated biochemical analysis and mass spectrometry studies of G-CSF-treated primary human myeloid cells. Our studies show that this novel E-selectin ligand is a glycoform of the heavy chain component of the enzyme myeloperoxidase (MPO), a well-known lysosomal peroxidase. This specialized MPO glycovariant, referred to as "MPO-E-selectin ligand" (MPO-EL), is expressed on circulating G-CSF-mobilized leukocytes and is naturally expressed on blood myeloid cells in patients with febrile leukocytosis. In vitro biochemical studies show that G-CSF programs MPO-EL expression on human blood leukocytes and marrow myeloid cells via induction of N-linked sialofucosylations on MPO, with concomitant cell surface display of the molecule. MPO-EL is catalytically active and mediates angiotoxicity on human endothelial cells that express E-selectin. These findings thus define a G-CSF effect on MPO chemical biology that endows unsuspected functional versatility upon this enzyme, unveiling new perspectives on the biology of G-CSF and MPO, and on the role of E-selectin receptor/ligand interactions in leukocyte migration and vascular pathology.
Spin-coupled theory applied to organic molecules and chemical reactions (1998)

El Objeto de esta Tesis es la aplicacion de la teoria de spin acoplado (spin-coupled theory) al enlace, estados excitados y reacciones quimicas en moleculas organicas. Se ha estudiado la estructura electronica de tres isomeros del benzeno con grupos metilenos exociclicos, los estados excitados del radical alilo, asi como dos reacciones periciclicas: la isomerizacion del ciclobuteno a cis-butadieno y el reagrupamiento de Cope en el 1,5-hexadieno.
Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival (2019)

This is the first report demonstrating durable macrochimerism beyond 8 weeks, as well as evidence for B cell tolerance in large animal xenotransplantation. Using hCD47Tg pigs as both IBBMTx and lung donors prolongs lung xenograft survival. However, additional strategies are required to control the acute loss of lung xenografts.
A Continuous Model for the Dynamical Analysis of Mistuned Bladed Rotors (2012)

Ideal bladed rotors are rotationally symmetric, as a consequence they exhibit couples of degenerate eigenmodes at coinciding frequencies. When even small imperfections are present destroying the periodicity of the structure (disorder or mistuning), each couple of degenerate eigenfrequencies splits into two distinct values (frequency split) and the corresponding modal shapes exhibit vibration amplitude peaks concentrated around few blades (localization phenomenon). In this paper a continuous model describing the in-plane vibrations of a mistuned bladed rotor is derived via the homogenization theory. Imperfections are accounted for as deviations of the mass and/or stiffness of some blades from the design value; a perturbation approach is adopted in order to investigate the frequency split and localization phenomena arising in the imperfect structure. Numerical simulations show the effectiveness of the proposed model, requiring much lower computational effort than classical finite element schemes.
Release of Anti-inflammatory Mediators after Mechanical Trauma Correlates with Severity of Injury and Clinical Outcome (1995)

Excessive synthesis of proinflammatory cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta] after trauma has been correlated with poor outcome. Recently, naturally occurring inhibitors of TNF-alpha and IL-1 beta have been characterized such as soluble TNF receptors (sTNFRs) and IL-1 receptor antagonist (IL-1ra). The present study was undertaken to determine whether injury results in a rise of circulating sTNFRs and IL-1ra. If so, whether plasma levels of these anti-inflammatory mediators correlate with severity of injury and clinical outcome of these patients. Injured patients (n = 213) showed significantly increased sTNFR and IL-1ra plasma levels throughout the observation period of 14 days, compared with healthy volunteers (n = 127). Patients with severe injury (Injury Severity Score > 16 points) revealed higher levels (p < 0.05) of sTNFRs and IL-1ra than patients with minor trauma (Injury Severity Score < or = 16 points). Patients who died from injury demonstrated increased (p < 0.05) sTNFR p55 and IL-1ra plasma levels, compared with survivors. Thus, anti-inflammatory mechanisms are activated after trauma dependent on severity of injury. Because increased plasma levels of anti-inflammatory reacting proteins portended poorly for patient survival, these mediators may contribute to prediction of outcome after severe injury.
Effects of antenatal magnesium sulfate therapy on cerebral and systemic hemodynamics in preterm newborns (2010)

Antenatal MgSO(4) exposure before preterm birth has potent systemic vascular effects in the preterm offspring, which is reflected in decreased neonatal cerebral perfusion during the critical first few days of life. This is associated with an increased incidence of patent ductus arteriosus, which may require operative intervention.
VI.—NEW BOOKS (1927)

Journal Article VI.—NEW BOOKS Get access Personality and Reality : A Proof of the Reality of a Supreme Self in the Universe. By J. E. TURNERLondon: George Allen & Uniwin, Ltd., 1926. Pp. 190. L. S. S. L. S. S. Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume XXXVI, Issue 141, January 1927, Pages 109-b–113, https://doi.org/10.1093/mind/XXXVI.141.109-b Published: 01 January 1927
QUANTUM YIELDS FOR LASER PHOTOCYCLIZATION OF BILIRUBIN IN THE PRESENCE OF HUMAN SERUM ALBUMIN. DEPENDENCE OF QUANTUM YIELD ON EXCITATION WAVELENGTH (1989)

The quantum yield for laser photocyclization of bilirubin to lumirubin in the presence of human serum albumin (phi LR) was measured at five monochromatic excitation wavelengths in the range 450-530 nm. Solutions used were optically thin throughout the wavelength range and precautions were taken to exclude contributions from photocyclization of bilirubin XIII alpha impurities. The values obtained (7.2-18 x 10(-4] were lower than those previously reported and showed the following wavelength dependence: 457.9 less than 488.0 less than 501.7 less than 514.5 approximately equal to 528.7. However, the rate of lumirubin formation, normalized to constant fluence, decreased with wavelength over the same wavelength range and no evidence was found that photoisomerization of bilirubin to lumirubin is faster with green (514.5 or 528.7 nm) than with blue (457.9 or 488.0 nm) light. The stereoselectivity of the configurational isomerization of bilirubin to 4Z,15E and 4E,15Z isomers also was studied. This reaction became less regioselective for the 4Z,15E isomer with increasing wavelength. The observed wavelength dependence of phi LR and of the [4E,15Z]: [4Z,15E] ratio at photoequilibrium are consistent with an exciton coupling model in which intramolecular energy transfer can occur between the two pyrromethenone chromophores of the bilirubin molecule in the excited state. Relative rates of lumirubin formation in vivo at different excitation wavelengths and constant fluence were estimated for different optical thicknesses and for different skin thicknesses. These estimates suggest that the recently reported clinical equivalence of blue and green phototherapy lights probably reflects the marked variation of skin transmittance with wavelength more than wavelength-dependent photochemistry. The calculations also indicated that the optimal wavelength for phototherapy is probably on the long wavelength side of the bilirubin absorption maximum.
PDI Improves Secretion of Redox‐Inactive β‐Glucosidase (2007)

Although manipulation of the endoplasmic reticulum (ER) folding environment in the yeast Saccharomyces cerevisiae has been shown to increase the secretory productivity of recombinant proteins, the cellular interactions and processes of native enzymes and chaperones such as protein disulfide isomerase (PDI) are still unclear. Previously, we reported that overexpression of the ER chaperone PDI enabled up to a 3-fold increase in secretion levels of the Pyrococcus furiosus beta-glucosidase in the yeast S. cerevisiae. This result was surprising since beta-glucosidase contains only one cysteine per monomer and no disulfide bonds. Two possible mechanisms were proposed: PDI either forms a transient disulfide bond with the lone cysteine residue of the nascent beta-glucosidase during the folding and assembly process or acts as a chaperone to aid in proper folding. To discern between the two mechanisms, the single cysteine residue was mutated to serine, and the secretion of the two protein variants was determined. The serine mutant still showed increased secretion in vivo when PDI levels were elevated. When the folding bottleneck is removed by increasing expression temperatures to 37 degrees C rather than 30 degrees C, PDI no longer has an improvement on secretion. These results suggest that, unexpectedly, PDI acts in a chaperone-like capacity or possibly cooperates with the cell's folding or degradation mechanisms regardless of whether the protein is redox-active.
Field trial of space-time equalizer and delay diversity transmission in uplink for TDMA mobile communication (2005)

Space-time (ST) equalizer and delay diversity transmission (DDT) were field tested in uplink for a time-division multiple-access mobile communication system. The ST equalizer used a cascade connection of constrained array processors and branch-metric-combining (BMC) maximum-likelihood sequence estimation which was designed to provide both space- and path-diversity gains from first-arrival and one-symbol-delay paths while suppressing excessive intersymbol interference. DDT with two antennas was used for the mobile transmitter to ensure sufficient path diversity at the ST equalizer in a small-delay-spread environment. Test results showed that the ST equalizer bit error rate (BER) was significantly better than an ST equalizer without BMC and a single array processor for both micro- and macrocell environments. Furthermore, the ST equalizer BER with DDT was better than that without DDT for the microcell environment.
Characteristics of a cell multiplexer for bursty ATM traffic (2003)

The performance of a cell multiplexer handling bursty input traffic is analyzed to evaluate the relation between cell loss rate or delay time and input traffic burstiness. A buffer design guideline is introduced for determining the queue size that satisfies service quality, such as permissible loss rate and delay time, on the condition that input traffic characteristics are given. Input traffic management and a congestion control scheme with a marking method are also discussed. Simulation results show that the marking method can improve service quality and network throughput.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A general algorithm for distributing information in a graph (2002)

We present a general "message-passing" algorithm for distributing information in a graph. This algorithm may help us to understand the approximate correctness of both the Gallager-Tanner-Wiberg algorithm, and the turbo-decoding algorithm.