gebhart/patrepeval huggingface dataset:
A Study of Serum Immunoglobulin Levels in Elderly Persons That Provides New Insights into B Cell Immunosenescence (2006)

The literature on immunosenescence has focused mainly on T cell impairment. With the aim of gaining insight into B cell immunosenescence, we investigated the serum immunoglobulin levels in a cohort of 166 subjects (20-106 years). Serum IgG (and IgG subclasses) were quantified by the nephelometric technique, IgE by CAP system fluorescence enzyme immunoassay, and IgD by radial immunodiffusion (RID). There was an age-related increase of IgG and IgA; the IgG age-related increase was significant only in men, but IgG1 levels showed an age-related increase both in men and women, whereas IgG3 showed an age-related increase only in men. IgE levels remain unchanged, whereas IgD and IgM serum levels decreased with age; the IgM age-related decrease was significant only in women, likely due to the relatively small sample of aged men. Thus, in the elderly the B cell repertoire available to respond to new antigenic challenge is decreased. A lot of memory IgD- B cells are filling immunological space and the amount of naïve IgD+ B cells is dramatically decreased. This shift away from a population of predominantly naïve B cells obviously reflects the influences of cumulative exposure to foreign pathogens over time. These age-dependent B cell changes indicate that advanced age is a condition characterized by lack of clonotypic immune response to new extracellular pathogens. In any event, the increase of memory B cells and the loss of naïve B cells, as measured by serum IgD levels, could represent hallmarks of immunosenescence and could provide useful biomarkers possibly related to the life span of humans.
<title>Wrapping 3D scanning data</title> (1998)

Geomagic Wrap<SUP>TM</SUP> is a commercially available software for reconstructing shapes and surfaces from 3D scanning data. The data can be any arbitrary finite point set in 3D, and there are no requirements on local density or organization in slices, etc. The software contains components for surface reconstruction, improvement, and analysis, and it supports a variety of input and output formats that make it compatible with scanning hardware and CAD and graphics software.
Prost (Antoine). — L'enseignement en France, 1800-1967 (1969)

Vial Jean. Prost (Antoine). — L'enseignement en France, 1800-1967. In: Revue française de pédagogie, volume 7, 1969. pp. 67-70.
Search-based automatic image annotation via Flickr photos using tag expansion (2010)

Exponentially growing photo collections motivate the needs for automatic image annotation for effective manipulations (e.g., search, browsing). Most of the prior works rely on supervised learning approaches and are not practical due to poor performance, out-ofvocabulary problem, and being time-consuming in acquiring training data and learning. In this work, we argue automatic image annotation by search over user-contributed photo sites (e.g., Flickr), which have accumulated rich human knowledge and billions of photos. The intuition is to leverage surrounding tags from those visually similar Flickr photos for the unlabeled image. However, the tags are generally few and noisy. To tackle such challenges, we propose a novel solution in three folds: (1) a tag expansion method to solve the sparsity of user-contributed tags; (2) improving tag relevance estimation by visual consistency between candidate annotations and the unlabeled image, and (3) the semantic tag consistence among candidate tags. Experimenting over Flickr photo benchmarks and requiring no additional keywords, we show that the proposed method significantly outperforms prior works and even provide more diverse annotations.
Weekly MLN9708, an investigational oral proteasome inhibitor (PI), in relapsed/refractory multiple myeloma (MM): Results from a phase I study after full enrollment. (2013)

8514 Background: MLN9708 is an investigational, orally bioavailable, potent, reversible, specific inhibitor of the 20S proteasome that has demonstrated antitumor activity in in vivo models of MM. We report safety, activity and pharmacokinetics (PK) of weekly oral MLN9708 in a phase 1 trial in patients (pts) with relapsed and/or refractory MM after full enrollment (NCT00963820). Methods: Pts received MLN9708 (days 1, 8, 15; 28-day cycles) at 0.24–3.95 mg/m 2 (dose-escalation phase) and at the MTD, 2.97 mg/m 2 , in relapsed and refractory (RR), bortezomib (btz)-relapsed, PI-naïve, and prior carfilzomib (CZ) expansion cohorts. Adverse events (AEs) were graded by NCI-CTCAE v3.0. Response was assessed by IMWG uniform criteria. Results: 60 pts (33 male, median age 64 yrs [40–79]) were enrolled, 32 in the dose-escalation phase and 31 to the expansion cohorts (11 RR, 10 btz-relapsed, 6 PI-naïve, 4 CZ; 2 RR and 1 btz-relapsed pts included from MTD dose-escalation cohort). Median time from MM diagnosis was 4.9 yrs (1.5–18.8). Median number of prior regimens was 6 (2–18), including btz, lenalidomide, thalidomide, and CZ in 83%, 95%, 52%, and 13%, respectively; 76% were refractory to last therapy (17% btz-refractory). At data cut-off (Nov 29, 2012) pts had received a median of 2 cycles (1–11); 5 pts remained on treatment. All-grade/grade ≥3 drug-related AEs were seen in 83%/52% of pts; common drug-related grade ≥3 AEs were thrombocytopenia (33%), diarrhea, neutropenia (17%), decreased appetite, fatigue, and lymphopenia (8%). 6 pts (10%) had drug-related PN (no grade ≥3). 5 pts discontinued due to drug-related AEs; 1 pt died on study due to an unrelated AE. By investigator assessment in 41 evaluable pts, responses included1 VGPR, 5 PR, 1 MR, and 15 with SD. MLN9708 was rapidly absorbed, with a terminal half-life of 4–12 days (supporting weekly dosing) and a proportional increase in plasma AUC with dose (0.8–3.95 mg/m 2 ). PK data were similar across expansion cohorts. Conclusions: Current data suggest weekly oral MLN9708 is generally well tolerated with infrequent PN, and shows activity in this heavily pretreated population with prior exposure to immunomodulatory drugs and btz. Clinical trial information: NCT00963820.
An autocompensating fiber-optic quantum cryptography system (2000)

Summary form only given. Quantum cryptography, or quantum key distribution (QKD), invented by Bennett and Brassard is a method for creating shared, assuredly secret, cryptographic key data over unsecured optical links. Security is guaranteed by the fundamental quantum properties of light. We describe our system in great detail, and report recent improvements and results obtained in generating error-corrected, privacy-amplified photographic key data over a 10-km single-mode fiber link. Bob transmits two orthogonally-polarized phase coherent pulses.
Underground storage systems (1986)

This study conducted a two-condition between-subjects laboratory experiment (<i>N</i> = 147) to examine the effects of textual disaster news combined with a 360° video in different modes (virtual reality [VR] vs. two dimensional screen) on cognitive/affective empathy and fear. Additionally, the mediating role of presence (social and spatial presence) was considered. Results indicated that the news article presented through an immersive VR mode directly led to greater levels of presence and cognitive empathy but not affective empathy and fear. The effects on social presence further resulted in greater cognitive and affective empathy, not fear. Meanwhile, spatial presence enhanced by VR led to greater levels of emotions (affective empathy and fear) but not cognitive empathy. These findings suggest the dynamic mechanisms of how an immersive VR modality can function as a complementary tool for traditional news to improve audience engagement, which centers on emotion-related outcomes in tandem with cognitive responses.
Compressed sensing of ultrasound images: Sampling of spatial and frequency domains (2010)

This paper proposes a comparison between an established (used in magnetic resonance imaging) and a innovative compressed sensing (CS) approach, both adapted to ultrasound (US) imaging. Two undersampling patterns suited to US imaging were investigated in each approach on simulated and in vivo radio-frequency US images. Reconstructions of simulated and in vivo US images using CS show minimal information loss. The best strategy (minimising the errors of reconstruction) was a uniform random sampling in the two directions of the spatial RF US image associated with the reconstruction of its k-space.
The Ammonium Carbomate Equilibrium (1924)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThe Ammonium Carbomate EquilibriumT. R. BriggsT. R. BriggsMore by T. R. Briggs and V. MigrdichianV. MigrdichianMore by V. MigrdichianCite this: J. Phys. Chem. 1924, 28, 11, 1121–1135Publication Date (Print):November 1, 1924Publication History Published online1 May 2002Published inissue 1 November 1924https://doi.org/10.1021/j150245a001RIGHTS & PERMISSIONSArticle Views578Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (723 KB) Get e-Alerts
Integration of polyelectrolyte enhanced ultrafiltration and chemical reduction for metal-containing wastewater treatment and metal recovery (2015)

Chemical reduction was firstly employed to treat synthetic wastewaters of various compositions prepared to simulate the retentate stream of polyelectrolyte enhanced ultrafiltration (PEUF). With fixed Cu:polyethylenimine (PEI) monomer:dithionite molar ratio, increasing copper concentration increases copper removal efficiency. Under fixed Cu:dithionite molar ratio and fixed Cu concentration, increasing PEI monomer:copper molar ratio decreases copper removal efficiency. The formation of nano-sized copper particles, which readily pass through 0.45 μm filter used for sample pretreatment before residual copper analysis, might be the reason behind the decreasing copper removal efficiency observed. Particle size analysis shows that the size of copper particles, which are formed through reduction reaction, increases with decreasing pH value and increasing reaction time. As ultrafiltration is capable of removing these nano-sized particles, integration of chemical reduction and PEUF is proposed to simultaneously achieve regeneration of polyelectrolyte and recovery of copper in one process. Results show that the proposed process could achieve almost complete copper removal without being affected by reaction pH.
Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils (1996)

The critical role of the liver in the resolution of systemic bacterial infections is well documented. In the case of Listeria monocytogenes, approximately 60% of bacteria inoculated i.v. into mice are recovered in the liver at 10 min after infection. Here we report that the Listeria recovered at 10 min were distributed equally among the hepatocyte and nonparenchymal liver cell populations. The majority (>/= 75%) of these organisms were bound extracellularly as judged by their sensitivity to gentamicin. In contrast, >/= 93% of Listeria recovered in the liver at 6 h were located within hepatocytes. The listerial burden of the liver decreased 0.5 to 1.0 log, between 10 min and 6 h after infection. This decrease correlated with a sevenfold increase in the percentage of neutrophils that constituted the nonparenchymal cell population. Mice rendered neutrophil deficient by pretreatment with anti-granulocyte (RB6-8C5) mAb exhibited a significant increase (>300%) rather than a decrease in liver Listeria and a marked increase in hepatocyte damage. Similarly, neutrophil-deficient mice exhibited a reduced capacity to eliminate Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus that were cleared by the liver and bound extracellularly to hepatocytes and nonparenchymal cells. These findings document the crucial role of immigrating neutrophils in nonspecific host defenses to systemic bacterial infections expressed within the liver.
Influence of aging and wetting on dynamic mechanical properties of multi-functional epoxy resins filled with pitch-based carbon short fibers (1998)

Pitch-based carbon and graphite short fibers (PCF and PGF) as functional filler materials were filled in multi-functional epoxy resin (EP) using five types of hardeners with 22.2 wt%. Influence of aging and wetting on dynamic mechanical properties of these materials was measured by the use of the nonresonant forced vibration method. Aging of the specimens were carried out at 130°C for 5000 h and wetting was carried out at 21°C in distilled water for 5000 h. The longer the aging time, the less the weight of the specimens which reached a maximum was 5.3 wt% after 5000 h. The glass transition temperature (Tg) for all the specimens increased. The storage moduli (E') for the aged specimens did not change much at low and room temperatures compared with those for the unaged specimens (UA) but they increased at high temperatures. The maximum wetting rate of the specimens was 5.1 wt% and the values of Tg decreased for all the specimens. The values of E' increased in the range from a low temperature (-140°C) to a room temperature (25°C) but they decreased at a high temperature (200°C). This tendency was more significantly observed in specimens cured with diamine hardeners than specimens cured with acid anhydrous hardeners.
Private Header (P-Header) Extensions to the Session Initiation Protocol (SIP) for the Open Mobile Alliance (OMA) Push to talk over Cellular (PoC) (2005)

This document describes a set of private Session Initiation
Protocol(SIP) headers (P-headers) used by the Open Mobile Alliance
(OMA),For Push to talk over Cellular (PoC) along with their
applicability, which is limited to the OMA PoC application. The
P-headers are used for requesting and indicating the alerting mode of
the handset which is particular to the PoC application.
Organocatalytic Asymmetric Mannich Cyclization of Hydroxylactams with Acetals: Total Syntheses of (−)‐Epilupinine, (−)‐Tashiromine, and (−)‐Trachelanthamidine (2014)

An asymmetric, organocatalytic, one-pot Mannich cyclization between a hydroxylactam and acetal is described to provide fused, bicyclic alkaloids bearing a bridgehead N atom. Both aliphatic and aromatic substrates were used in this transformation to furnish chiral pyrrolizidinone, indolizidinone, and quinolizidinone derivatives in up to 89% yield and 97% ee. The total syntheses of (-)-epilupinine, (-)-tashiromine, and (-)-trachelanthamidine also achieved to demonstrate the generality of the process.
A parallel-programming process model (1989)

A process model is presented for constructing and executing parallel programs on a shared-memory multiprocessor running under Unix. The model involves some simple extensions to the standard Unix process model, a set of language extensions, runtime library support, and additional operating-system support. The model is easy to use, and it supports several higher-level parallel programming constructs in several languages, including microtasking in C and Fortran and multitasking in Ada and C++. It frees programmers to concentrate on parallel algorithms instead of low-level implementation details, and it yields good performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
DEVELOPMENT AND OPERATION OF BURIED CHANNEL CHARGE COUPLED DEVICES IN 6H SILICON CARBIDE (1996)

Silicon carbide is a wide bandgap semiconductor that is well suited for high power, high temperature electronic devices due to its remarkable electronic and thermal properties. Photosensitive devices in the 6H polytype of SiC have also been demonstrated, showing high sensitivity in ultraviolet wavelengths near 270 nm. Furthermore, the native oxide on SiC is silicon dioxide, meaning that SiC can be thermally oxidized to form a high quality gate dielectric, making metal-oxide-semiconductor (MOS) devices possible. These qualities make silicon carbide ideal for constructing UV sensitive CCD imagers. This work investigates the feasibility for developing imagers in SiC through the fabrication and demonstration of a buried channel CCD linear shift array. Several elements of the MOS field effect family were studied. With careful surface preparation and device processing techniques, SiC/silicon-dioxide interfaces have been ameliorated to achieve surface state densities below 2e11 per-centimeters-squared and electron surface mobilities above 40 centimeters-squared-per-volt-second. Buried channel MOSFETs were fabricated with ion implantation of nitrogen at elevated temperatures and have functioned with electron mobilities in excess of 180 centimeters-squared-per-volt-second, which shows an advantage of using the buried channel structure. Studies of capacitance characteristics of the buried channel devices hold good agreement with a general one-dimensional depletion model. A double polysilicon level, overlapping gate process was adapted to the SiC/MOS system. A four phase buried channel CCD shift register was built and operated in the pseudo-two phase configuration at room temperature. Device clocking frequencies were limited to 30 kHz by slow charge readout techniques, but higher speeds have been estimated. In this frequency range, charge transfer efficiencies were probably dominated by carrier trapping in bulk states, which may be present due to ion implantation. Recommendations for improvement of device performance and methods of integrating the CCD with UV photodetectors are given.
The subclass distribution of human IgG rheumatoid factor. (1987)

The subclass distribution of IgG rheumatoid factor (RF) was determined by a sensitive ELISA assay in sera from patients with rheumatoid arthritis and from normal controls. In both instances, the most important subclasses were IgG1 and IgG4. The IgG4 RF was directed against the Fc region of IgG, and recognized human as well as rabbit IgG. Although human IgG4 myeloma proteins bound to rabbit IgG better than did myelomas of other IgG subclasses, the IgG4 RF activity in rheumatoid sera showed an additional specificity, because the fraction of IgG4 RF/total IgG4 for rheumatoid arthritis sera was far greater than for myelomas. This inference was supported by the observation that there was persistent, albeit diminished, IgG RF activity in pepsin-digested, RF-containing sera (but not myeloma proteins), indicating that a critical component of IgG4 RF activity was contained within the Fab region of the IgG4 molecule. The finding of large quantities of IgG4 RF was not due to a bias of the assay, because the preponderance of IgG4 did not extend to the subclass distribution of antibodies directed against other antigens. The demonstration of an important role for IgG4 as a RF is of special interest because of the relative inability of this subclass to fix complement or to bind to Fc receptors, and because of its potential role as a mediator of increased vascular permeability.
Robot mechanism synthesis and genetic algorithms (2002)

We propose to explore the problem of mechanism synthesis with an approach using genetic algorithms. We intend to study the case where there exist geometric constraints (as avoiding obstacles). More precisely, we are interested in the choice of robots (morphology and position) which has to follow a given trajectory among obstacles.
Singular beams in metrology and nanotechnology (2011)

Optical singularities are localized regions in a light field where one or more of the field parameters, such as phase or polarization, become singular with associated zero intensity. Focused to a small spot, the electromagnetic field around the singularity has interesting characteristics, in particular when it interacts with matter. The light scattered by a material object within the strongly varying optical field around the singularity is extremely sensitive to changes and can be exploited for metrology with high sensitivity and the study of physical processes on a nanometer scale.
The Chemistry of Selenium, Tellurium, and Polonium. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe Chemistry of Selenium, Tellurium, and Polonium.Robert C. LangeCite this: J. Am. Chem. Soc. 1966, 88, 19, 4548Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/ja00971a073https://doi.org/10.1021/ja00971a073research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Physical Demands of Daily Life (1945)

(An Objective Scale for Rating the Orthopedically Exceptional) By George G. Deaver, M.D., and Mary Eleanor Brown, M.A. 36 pages. Illustrated. Institute for the Crippled and Disabled, New York to, New York. 1945. Price, 10 cents.
What you see is what you need (2003)

We studied the role of attention and task demands for implicit change detection. Subjects engaged in an object sorting task performed in a virtual reality environment, where we changed the properties of an object while the subject was manipulating it. The task assures that subjects are looking at the changed object immediately before and after the change. Our results demonstrate that in this situation subjects' ability to notice changes to the object strongly depends on momentary task demands. Surprisingly, frequent noticing is not guaranteed by task relevance of the changed object attribute per se, but the changed object attribute needs to be task relevant at exactly the right times. Also, the simplicity of the used objects indicates that change blindness occurs in situations where the visual short term memory load is minimal, suggesting a potential dissociation between short term memory limitations and change blindness. Finally, we found that changes may even go unnoticed if subjects are visually tracking the object at the moment of change. Our experiments suggest a highly purposive and task specific nature of human vision, where information extracted from the fixation point is used for certain computations only "just in time" when needed to solve the current goal.
Graphene Based Materials for Biosensing and Imaging (2012)

Abstract not Available.