gebhart/patrepeval huggingface dataset:
Nonlinear, data-driven modeling of cardiorespiratory control mechanisms (2009)

We present applications of recently developed algorithms for data-driven nonlinear systems identification to the study of cardiovascular and respiratory control mechanisms on an integrated systems level, utilizing experimental data obtained during resting conditions. Specifically, we consider cerebrovascular regulation during normal conditions, orthostatic stress and autonomic blockade in a two-input context, as well as respiratory control during a model opioid drug (remifentanil) infusion in a closed-loop context. The results illustrate the potential of using data-driven modeling approaches, which do not rely on prior assumptions about model structure, for modeling physiological systems, as they are well-suited to their complexity. They also illustrate the potential of utilizing spontaneous physiological variability, which can be monitored noninvasively and does not require experimental interventions, to extract rich information about the function of the underlying mechanisms. We also discuss some important practical issues, such as the presence of nonstationarities and model order selection, related to the application of similar approaches to the analysis of physiological systems.
Update on the Puerto Rico electric power authority's spinning reserve battery system (2002)

The Puerto Rico electric power authority completed start-up testing and began commercial operation of a 20 MW/14 MWh battery energy storage facility in April 1995. The battery system was installed to provide rapid spinning reserve and frequency control for the utility's island electrical system. This paper outlines the needs of an island utility for rapid spinning reserve; identifies Puerto Rico's unique challenges; reviews the technical and economic analyses that justified installation of a battery energy system; describes the storage facility that was installed; and presents preliminary operating results of the facility.
Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients. (1986)

Two patients (brother and sister, 41 and 39 yr of age, respectively) have been shown to have marked elevation of plasma triglycerides and chylomicrons, decreased low density lipoproteins (LDL) and high density lipoproteins (HDL), a type I lipoprotein phenotype, and a deficiency of plasma apolipoprotein C-II (apo C-II). The male patient had a history of recurrent bouts of abdominal pain often accompanied by eruptive xanthomas. The female subject, identified by family screening, was asymptomatic. Hepatosplenomegaly was present in both subjects. Analytical and zonal ultracentrifugation revealed a marked increase in triglyceride-rich lipoproteins including chylomicrons and very low density lipoproteins, a reduction in LDL, and the presence of virtually only the HDL3 subfraction. LDL were heterogeneous with the major subfraction of a higher hydrated density than that observed in plasma lipoproteins of normal subjects. Apo C-II levels, quantitated by radioimmunoassay, were 0.13 mg/dl and 0.12 mg/dl, in the male and female proband, respectively. A variant of apo C-II (apo C-IIPadova) with lower apparent molecular weight and more acidic isoelectric point was identified in both probands by two-dimensional gel electrophoresis. The marked hypertriglyceridemia and elevation of triglyceride-rich lipoproteins were corrected by the infusion of normal plasma or the injection of a biologically active synthesized 44-79 amino acid residue peptide fragment of apo C-II. The reduction in plasma triglycerides after the injection of the synthetic apo C-II peptide persisted for 13-20 d. These results definitively established that the dyslipoproteinemia in this syndrome is due to a deficiency of normal apo C-II. A possible therapeutic role for replacement therapy of apo C-II by synthetic or recombinant apo C-II in those patients with severe hypertriglyceridemia and recurrent pancreatitis may be possible in the future.
System Identification and Control using Diagonal Recurrent Neural Networks (1992)

This paper presents an approach for control and system identification using Diagonal Recurrent Neural Networks (DRNN). An unknown plant is identified by a Diagonal Recurrent Neuroidentifier (DRNI), and provides the sensitivity information of the plant to a Diagonal Recurrent Neurocontroller (DRNC). A dynamic backpropagation (DBP), is developed to train both DRNC and DRNI. The DRNN captures the dynamic nature of a system and since it is not fully connected, training is much faster than a fully connected recurrent neural network. The architecture of DRNN is a modified model of the fully connected recurrent neural network with one hidden layer. The hidden layer is comprised of self-recurrent neurons, each feeding its output only into itself. The dynamic backpropagation algorithm (DBP) is developed to train the recurrent neural networks for dynamic mappings, which are found in applications such as control, speech processing and sequential cognition. The proposed DRNN architecture is applied to numerical problems and the simulation results are included.
Whole body positron emission tomography imaging of simian immunodeficiency virus-infected rhesus macaques. (1996)

Pathogenesis of simian immunodeficiency virus (SIV) infection in rhesus macaques begins with acute viremia and then progresses to a distributed infection in the solid lymphoid tissues, which is followed by a process of cellular destruction leading to terminal disease and death. Blood and tissue specimens show the progress of infection at the cellular level but do not reveal the pattern of infection and host responses occurring throughout the body. The purpose of this investigation was to determine whether positron emission tomography (PET) imaging with intravenous 2-18F-2-deoxyglucose (FDG) could identify activated lymphoid tissues in a living animal and whether this pattern would reflect the extent of SIV infection. PET images from SIV-infected animals were distinguishable from uninfected controls and revealed a pattern consistent with widespread lymphoid tissue activation. Significant FDG accumulation in colon along with mesenteric and ileocaecal lymph nodes was found in SIV infection, especially during terminal disease stages. Areas of elevated FDG uptake in the PET images were correlated with productive SIV infection using in situ hybridization as a test for virus replication. PET-FDG images of SIV-infected animals correlated sites of virus replication with high FDG accumulation. These data show that the method can be used to evaluate the distribution and activity of infected tissues in a living animal without biopsy. Fewer tissues had high FDG uptake in terminal animals than midstage animals, and both were clearly distinguishable from uninfected animal scans.
Microstructure control and extrudability of Al–Mg–Si alloys microalloyed with manganese (1994)

AbstractThe hot deformation of AA 6063 and AA 6005 Al alloys has been related to chemical composition and the microstructural evolution occurring during the various heat treatment procedures before extrusion. It was shown that a small addition of Mn significantly accelerates the homogenising process (transformation of the brittle platelike β-AlFeSi phase to the more rounded α-AlFeSi phase) which results in superior hot formability and ductility. The mechanical behaviour of Al–Mg–Si alloys during hot deformation can be explained in terms of a model of dislocations climbing around particles. Large β phase particles increase initial work hardening rate and flow stress and impair hot ductility. The hot ductility of the material investigated via tensile testing was found to correlate with the density of particles covering grain boundaries. It was also shown that grain refinement in the billet leads to more uniform distribution of intermetallic constituents, which accelerates the homogenising process and improves the hot ductility. Full scale extrusion trials show that the results from hot formability tests in the laboratory correlate closely with the relative extrudability of the investigated alloys.MST/1877
Cellular Fatty Acid profiles of lactobacillus and lactococcus strains in relation to the oleic Acid content of the cultivation medium (1995)

Cellular fatty acids of 10 strains of lactic acid bacteria were analyzed. The purpose of this work was to find lactic acid bacteria with high lactobacillic acid contents. The bacteria studied were unable to synthesize oleic acid. Some strains did not synthesize lactobacillic acid, although all were able to form dihydrosterculic acid. Twenty-one to thirty-four percent of the fatty acid content of Lactobacillus fermentum and L. buchneri was lactobacillic acid, and these species were chosen for future studies of environmental factors affecting cyclopropane fatty acid synthesis.
Recombination lifetime and trap density variations in multicrystalline silicon wafers through the block (2005)

We have studied the variations in recombination lifetime and density of non-recombinative traps between wafers through the entire height of a multicrystalline silicon block. We find that the low lifetime regions in the very bottom and top part of an ingot are described by a relatively high density of non-recombinative traps. It is argued that in the bottom region in-diffused impurities from the crucible, as well as grain boundaries and dislocations, could be the major trap contributors. In the upper region, trapping is believed to be due to high concentrations of metallic impurities, caused by segregation during growth and solid-state diffusion during cooling of the ingot. Moreover, we have investigated the gettering response of wafers from different positions within the block from a 50/spl Omega//sq phosphorus emitter diffusion. The results show that the most notable lifetime enhancements occur in regions of the block where the trap density is high, indicating the relevance of mobile impurities as non-recombinative trapping centers.
<i>Mahonia aquifolium</i>: A new type of topical treatment for psoriasis (1995)

In an open, prospective multicentre trial in 89 dermatological practices in Germany, 433 patients with subacute and chronic forms of psoriasis were treated with Mahonia aquifolium ointment (Rubisan). M. aquifolium ointment is used as a homoeopathic preparation (according to the German Homoeopathic Pharmacopeia). Of 433 patients entered into the study, 375 were treated over the planned period of 12 weeks, or dropped out of the study early because of healing. A modified PASI score fell significantly from 5.5 ± 4.0 to 2.3 ± 2.6. According to an overall evaluation by dermatologists, symptoms improved or disappeared in 81.1% of patients. According to a subjective evaluation by the patients, 79.7% improved or healed completely. The tolerability of M. aquifolium ointment was evaluated as good or very good by 82.4% of patients. There was a significant improvement in the quality of life, which was used as a subjective parameter throughout the study. While 30.1% of patients had significant or severe symptoms at the start, this was the case for only 5.6% after 12 weeks. M. aquifolium ointment is thus a well-tolerated preparation which should find a place in the treatment of psoriasis.
Development and Evaluation of Laser Doppler Techniques for Measurements of Flexural and Longitudinal Structural Intensity (1991)

Based on the hypothesis that both flexural and longitudinal vibrational energy flow can be measured non-intrusively by an optical technique which can be extended to broadband vibrations, a two-channel laser vibrometer system is developed and evaluated for cross-spectral power flow measurements. The cross-spectral power flow results from tests on small resonant beams and rods are verified by comparison with one-dimensional energetics and standing wave power flow results (obtained with a single scanning laser beam of the two- channel vibrometer). Among the contributions of the thesis are: development and validation of the laser technique for measuring flexural power flow in reverberant fields; introduction of a procedure to maximize phase accuracy which eliminates phase bias error and coherent noise error; an investigation into the differential Doppler method for measuring longitudinal power flow including an analytical model of the effects of bending on the longitudinal power flow measurements; studies of the optical parameters which dictate the performance of the reference beam method and differential Doppler method; and a quantification of how physical and measurement parameters affect the accuracy of this nonintrusive two-point vibrational power flow measurement.
SOC 노후화로 인한 도심형 재난 유형 분석 및 대비 방안에 관한 연구 (2016)

최근 들어 SOC(사회간접자본)의 노후화는 전 세계적으로 심각한 문제로 주목받고 있다. SOC 시설물의 노후화 비율은 극적으로 증가하고 있으며 이에 따른 도심형 재난을 초래하고 있다. SOC시설물의 노후화는 도심형 싱크홀, 가스관의 폭발 그리고 지하철과 같은 운송시설의 사고를 초래한다. 그러나 노후 SOC에 대한 예산은 점차 감소하는 추세이기 때문에 노후 SOC의 재건이나 재생이 활발히 이루어져야 한다. 이와 더불어 최신의 과학 기술을 결합해 사용되어야
An extrapolation procedure for band-limited signals (1979)

In this paper, the task of extrapolating a time-truncated version of a band-limited signal shall be considered. It will be shown that the basic extrapolation operation is feasible for only a particular subset of the class of band-limited signals (i.e., the operation is well-posed mathematically). An efficient algorithmic method for achieving the desired extrapolation on this subset is then presented. This algorithm is structured so that all necessary signal manipulations involve signals which are everywhere zero except possibly on a finite "observation time" set. As a consequence, its implementation is straightforward and can be carried out in real time. This is to be contrasted with many existing extrapolation algorithms which theoretically involve operations on signals that are nonzero for almost all values of time. Their numerical implementation thereby necessitates an error producing time-truncation and a resultant deleterious effect on the corresponding extrapolation. Using straightforward algebraic operations, a convenient one-step extrapolation procedure is next developed. This is noteworthy in that this procedure thereby enables one to effectively circumvent any potentially slow convergence rate difficulties which typically characterize extrapolation algorithms. The effectiveness of this one-step procedure is demonstrated by means of two examples.
Mucolipidosis type IV: The importance of functional lysosomes for efficient autophagy (2008)

Mucolipidosis IV (MLIV) is a lysosomal storage disorder characterized by severe neurological and ophthalmologic abnormalities. In contrast with most lysosomal storage disorders, which are attributed to the absence of specific lysosomal hydrolases, accumulation of material in MLIV results from defects in membrane transport along the late endocytic pathway. Mutations in MCOLN1 are the cause of MLIV; however, how the lack of MCOLN1 function ultimately leads to neurodegeneration remains largely unknown. We found that MCOLN1 is required for efficient fusion of both late endosomes and autophagosomes with lysosomes. Impaired autophagosome degradation results in accumulation of autophagosomes in MLIV fibroblasts. In addition, we found increased levels and aggregation of p62, suggesting that abnormal accumulation of ubiquitinated protein inclusions may contribute to the neurodegenerative phenotype observed in MLIV patients. These findings corroborate recent evidence indicating that defects in autophagy may be a common feature of many neurodegenerative disorders.
Reagents for transition metal complex and organometallic syntheses (1990)

Complexes with Weakly Coordinated Ligands Low-Valent Complexes Substitute Metal Carbonyl Complexes Metal Carbonyl Anions Transition Metal Clusters Cyclopentadienyl Clusters Lanthanide and Actinide Complexes Other Complexes and Ligands.
Total parenteral nutrition and enteral nutrition in diabetes (2000)

A quarter or more of critically ill patients are likely to have carbohydrate intolerance or frank diabetes, either pre-existing or secondary to the stress of illness. Those patients who require parenteral nutrition should be treated using regimens similar to those used in nondiabetic patients, along with sufficient insulin (given by separate infusion) to maintain near-normal glycaemia. The role of novel substrates in diabetes remains to be established. In patients who require enteral nutrition, there is accumulating evidence that high-fat (as monounsaturated fatty acid) formulations achieve better overall metabolic control than conventional high-carbohydrate preparations. In view of the fact that macrovascular disease is the major cause of morbidity and mortality in type 2 diabetes in particular, and the fact that the risk of macrovascular complications is relatively unaffected by glycaemic control, the improved lipid and haemostatic profile achieved with preparations that are high in monounsaturated fatty acids is of particular importance in patients on long-term nutritional support.
An improved method for southwestern blotting (1997)

We have developed a modified Southwestern blotting technique which utilizes broad-spectrum protease inhibitors during nuclear protein extraction and a procedure for radiolabelling an oligonucleotide probe to a high specific activity. These modifications have resulted in minimal protein degradation during nuclear protein isolation and have permitted room temperature hybridizations, improving both the facility and sensitivity of the standard Southwestern assay. This technique was used in our laboratory to visualize NFAT-1 consensus sequence binding proteins in nuclear extracts of human promyelocytic HL-60 cells.
Neural network pruning for function approximation (2000)

A simple algorithm for pruning feedforward neural networks with a single hidden layer trained for function approximation is presented. The algorithm assumes that the networks have been trained with more then the necessary number of hidden units and it consists of two stages. In the first stage redundant hidden units are removed, and in the second stage irrelevant input units are removed. Experimental results on seven publicly available data sets show that the proposed algorithm outperforms other methods such as the nearest neighbors, decision trees and regression-based methods.
Advanced mean-field theory of the restricted Boltzmann machine (2015)

Learning in restricted Boltzmann machine is typically hard due to the computation of gradients of log-likelihood function. To describe the network state statistics of the restricted Boltzmann machine, we develop an advanced mean-field theory based on the Bethe approximation. Our theory provides an efficient message-passing-based method that evaluates not only the partition function (free energy) but also its gradients without requiring statistical sampling. The results are compared with those obtained by the computationally expensive sampling-based method.
Halogenation of pyrimidine 6-O-cyclonucleosides (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalogenation of pyrimidine 6-O-cyclonucleosidesTokumi Maruyama, Shuhei Kimura, Yoshiko Sato, and Mikio HonjoCite this: J. Org. Chem. 1983, 48, 16, 2719–2723Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/jo00164a016https://doi.org/10.1021/jo00164a016research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Author Response (1994)

In the commentary, Dr Dean questions the basis for the conclusions reached in our article based on the methodological problems of the source studies used in the meta-analysis, as well as heterogeneity within the analysis. We concur with the view that body positioning and mobilization potentially have much value, and that is why they characterize much of the usual postoperative care and protocol delivered by physical therapists (vide infra) and other health professionals working in the perioperative setting. Quantification of the stimuli that will or may alter ventilation/perfusion patterns in the initial postoperative recovery will provide a substantial challenge for most investigators, given the numerous brief disturbances and events that occur around the patient. The minimal methodological standard acceptable for this analysis was “randomized trials.”…
Flow cytometric monocyte phagocytic assay for predicting platelet transfusion outcome (2002)

FMPA is designed with near in vivo conditions to measure an immune response to transfused platelets, including phagocytosis. This is a useful method for predicting the outcome of platelet transfusion.
[Identification of 2 allelic mutations of the gene of the phosphodiesterase beta subunit in a Spanish family with recessive autosomic retinitis pigmentosa]. (1998)

The nature of the mutations in the PDEB gene and their pattern of inheritance indicate that the lack of activity of the phosphodiesterase (PDE), a key enzyme in the visual phototransduction process, account for the RP phenotype in these patients.
Development of specific nanobodies (VHH) for CD19 immuno-targeting of human B-lymphocytes. (2018)

Specific Nbs possess the potential to be used as novel therapeutic approaches in order to treat autoimmune diseases and B-cell lymphoma.
Capacitive micromachined ultrasonic transducers with integrated optoelectronic readout (2002)

Capacitive detection methods impose several limitations on the performance of capacitive micromachined ultrasound transducers (cMUT) such as low sensitivity below MHz frequencies and low limits on acoustic power output. Optical interferometric detection of cMUT membrane displacement solves these problems by providing a flat frequency response down to DC and electrical isolation between transmitting and receiving electronics. A phase-sensitive optical diffraction grating structure formed by placing a grated electrode under the cMUT membranes enables integration of optoelectronic readout circuitry to cMUT arrays while allowing efficient transmit operation using capacitive actuation. This structure is used to measure membrane displacements down to 10/sup -4/ /spl Aring///spl radic/Hz level in the DC-2MHz range on cMUTs fabricated on quartz substrates. The possibility of enhanced displacement sensitivity for immersion applications by forming a multi-pass interferometer is discussed and an optical analysis of the detection method is described. The feasibility of hybrid optoelectronics integration for phased array operation is also demonstrated by experiments on cMUTs using vertical cavity surface emitting lasers and 1/spl times/8 array of photodetectors with integrated CMOS amplifiers.