gebhart/patrepeval huggingface dataset:
Seraphic Companions: The Friendship between Elizabeth Gauden and Simon Patrick (2014)

This essay explores the friendship between Simon Patrick, future bishop of Ely, and Elizabeth Gauden, one of his parishioners, as an example of Neo-Platonic, chaste, yet impassioned friendship, between the sexes: Based on a combination of Neo-Platonic metaphysics of love, Aristotelian notions of philia , and legitimised by the ideal of Christian charity, the friendship’s spiritual aim is the two ‘soul mates’’ mutual intellectual and emotional refinement in order to be united with the heavenly community and the divine. The ideal of their seraphic companionship is to be achieved through the every-day practice of their friendship, that is, in their actual meetings and through their correspondence (Cambridge University Library Add. MS 19). Patrick and Gauden act as friends by discussing questions of theological and philosophical import, by advising each other on matters spiritual and mundane, and by sharing in social and devotional practices. Through Simon Patrick, the two friends are connected to a ‘this-worldly’ intellectual and religious community the philosophical and theological origins of which can be located within the most important school of seventeenth-century Platonic philosophy, Cambridge Platonism. Patrick, too, counts as a Cambridge Platonists, whose theological views and emphasis on matters of practical divinity characterise him as a prominent figure of post-Restoration liberal Anglicanism. Simon Patrick and Elizabeth Gauden are a virtually unknown example of the seventeenth century trend for intellectual friendships between men and women as Ruth Perry has identified it (1985) . The friendship between Patrick and Gauden is presented as a form of sociability that offered women a dynamic role within the learned community and furthered their active religious participation. With a close focus on the literary performance of friendship, my discussion explores how the two companions conformed to the protocols of private correspondence, but also shows how far they transformed these rules to suit their own spiritualising ends. The letter was a genre available to early modern men and women alike, and its particular communicative structure, its dialogic nature and its status as disembodied communication are presented as ideally suited for the practice of an idealised friendship between the sexes, since these features allow for intellectual intimacy, spiritual union, and affectionate excess on the letter’s page. The essay analyses the dynamics of Patrick and Gauden’s correspondence as the performance of their friendship and as the textualisation of central Neo-Platonic notions of the loving relations between the human and the divine. The focus is on Patrick’s rhetoric of unlimited and unconfined affection that questions contemporaneous norms of passionate involvement, and on Patrick’s epistolary idealisations of himself and his friend as philosophical companions. Both discursive strategies are meant to transport the seraphic friends beyond the earthly and into the heavenly community.
The changing pattern of infant mortality in the US: The role of prenatal factors and their obstetrical implications (1993)

Infant mortality is one of the leading public health problems in the United States today. During the first half of this century the decline in infant mortality resulted largely from a reduction in postneonatal deaths (2-11 months after birth). Since 1950, two-thirds of all infant deaths have occurred in the neonatal period (1st month after birth). Since 1981, the rate of decline in the infant mortality rate has slowed due to a deterioration in the distribution of birthweights and a slowed improvement in birthweight-specific mortality rates. The role of birthweight is central to this issue, because low birthweight (LBW, < 2500 g) is a major determinant of death in the first year of life, particularly during the neonatal period. Stated another way, less than 0.5% of infants with birthweights > 2500 g die during the first year of life compared to 10.2% of infants with birthweights < 2500 g and 45.3% with birthweights < 1500 g (very low birthweight, VLBW). These effects are magnified when evaluated on a race-specific basis: the rate of LBW is twice as high and the rate of VLBW is three times as high for black infants compared to white infants. Reducing the rates of VLBW and LBW, particularly among blacks, holds the greatest potential for future reductions in infant mortality in the United States. The important role of maternal factors in the antecedents of infant mortality (VLBW, LBW, intrauterine growth retardation, preterm birth) have been clearly and repeatedly demonstrated. Some of these factors, such as maternal race, adverse obstetrical history and low level of education, are not amenable to change during pregnancy. Other factors, such as cessation of smoking, higher maternal weight gain and the initiation of early prenatal care have been shown to improve the course and outcome of pregnancy and subsequently result in reduced infant mortality.
7-Hydroxy-benzopyran-4-one Derivatives: A Novel Pharmacophore of Peroxisome Proliferator-Activated Receptor α and -γ (PPARα and γ) Dual Agonists (2009)

Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARalpha and gamma agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavones) is the key pharmacophore of these novel molecules, exhibiting similarity to the core structure of both fibrates and thiazolidinediones. New lead PPAR ligands were identified from "natraceuticals" and synthetic analogues. In total, 77 molecules, including chalcones, flavones, flavanones, isoflavones, and pyrazole derivatives, were screened and structure-activity relationship studies of the dual agonists undertaken. Compounds 68, 70, 72, and 76 were identified as novel and potent dual PPARalpha and gamma agonists. These novel molecules may have the potential to be the future leads in PPAR-related disorders, including type II diabetes mellitus and metabolic syndrome.
Genetics and Physiology of Acinetobacter (1978)

INTRODUCTION 350 TAXONOMY 350 ECOLOGY 352 GENETICS 353 Trans/ormation 353 Transduction 353 Conjugation 354 Mapping Studies 354 PHYSIOLOGY ..... 354 Growth and Nutrition 354 Pathways for Glucose and Pentose Dissimilation 355 Enzymes of the Tricarboxylic Acid and Glyoxylate Cycles 356 Malic Enzymes and Metabolism of C4Dicarboxylic Acids 357 Dissimilatory Pathways 358 Aromatic compounds 358 Hydrocarbons 360 Alicyclic compounds 361 2,3-Butanediol 361 Electron Transport Pathways ...... 362 Extracellular Hydrolytic Enzymes 363 BIOSYNTHESIS ........ ........ ..... ....... 363 Gluconeogenesis ..... 363 Nitrogen Assimilation and Utilization 364 Amino Acid Biosynthesis 365 Tryptophan 365 Branched-chain amino acids 365 Nucleic Acid Metabolism 366 Cell Envelopes and Surface Structures 366 CONCLUDING REMARKS 367
Quantitative trait loci underlying resistance to sudden death syndrome (SDS) in MD96-5722 by ‘Spencer’ recombinant inbred line population of soybean (2014)

The best way to protect yield loss of soybean [Glycine max (L.) Merr.] due to sudden death syndrome (SDS), caused by Fusarium virguliforme (Aoki, O'Donnel, Homma & Lattanzi), is the development and use of resistant lines. Mapping quantitative trait loci (QTL) linked to SDS help developing resistant soybean germplasm through molecular marker-assisted selection strategy. QTL for SDS presented herein are from a high-density SNP-based genetic linkage map of MD 96-5722 (a.k.a 'Monocacy') by 'Spencer' recombinant inbred line using SoySNP6K Illumina Infinium BeadChip genotyping array. Ninety-four F<sub>5:7</sub> lines were evaluated for 2 years (2010 and 2011) at two locations (Carbondale and Valmeyer) in southern Illinois, USA to identify QTL controlling SDS resistance using disease index (DX). Composite interval mapping identified 19 SDS controlling QTL which were mapped on 11 separate linkage group (LG) or chromosomes (Chr) out of 20 LG or Chr of soybean genome. Many of these significant QTL identified in one environment/year were confirmed in another year or environment, which suggests a common genetic effects and modes of the pathogen. These new QTL are useful sources for SDS resistance studies in soybean breeding, complementing previously reported loci.
Activated Farnesoid X Receptor inhibits growth of tamoxifen‐resistant breast cancer cells. (2010)

Background Farnesoid X Receptor (FXR) is mainly expressed in enterohepatic district where regulates lipids metabolism and glucose homeostasis. Recently, new functions of FXR were discovered including its capability to induces apoptosis in breast cancer cells, but the role of FXR in modulating growth of these cells are not fully elucidated. Results In this study we evaluated the effects of chenodeoxycholic acid (CDCA), natural ligand of FXR, on growth of breast cancer cell lines sensitive (MCF‐7) and resistant to tamoxifen (MCF‐7TR). Using MTT assay we found that CDCA as well as GW4064, a specific synthetic FXR agonist, reduced cell viability in MCF‐7 and in a higher extent in MCF‐7TR cells. Furthermore, results from anchorage independent growth assay (soft agar) demonstrated that CDCA inhibited tamoxifen‐resistant colonies formation as well as Epidermal Growth Factor (EGF) induced growth in MCF‐7TR cells. Western blot analysis and real‐time RT‐PCR revealed that FXR activation determined a reduction of HER2 expression and consequently an inhibition of EGF‐mediated HER2 and p42/44 MAPK phosphorylation in MCF‐7 TR cells. Conclusion These data suggest that FXR ligand‐dependent activity, blocking HER2/MAPK signaling, may reverse antiestrogen resistance in human breast cancer cells and could represent a new therapeutic tool to treat breast cancer patients that develop hormonal resistance.
XXII.—studies on sulphonic acids. No. I. On the hydrolysis of sulphonic acids and on the recovery of the benzenes from their sulphonic acids (1884)

H. E. Armstrong and A. K. Miller, J. Chem. Soc., Trans., 1884, 45, 148 DOI: 10.1039/CT8844500148
Relationship among Current Fluctuations during Forming, Cell-To-Cell Variability and Reliability in RRAM Arrays (2015)

In this work, cells behavior during forming is monitored through an incremental pulse and verify algorithm on 4kbit RRAM arrays. This technique allows recognising different cell behaviors in terms of read-verify current oscillation: the impact of these oscillations on reliability and cell-to-cell variability has been investigated during 1k endurance cycles and 100k pulse stress under a variety of cycling conditions. Conductance histograms for the post-forming current reveal the nanosized nature of the filamentary paths across the dielectric film.
Outcomes following intra-amniotic instillation with indigo carmine to diagnose prelabor rupture of membranes in singleton pregnancies: a single center experience (2015)

Equivocal diagnosis of PPROM should warrant an amniodye test to avoid iatrogenic intervention in women with intact amniotic membranes. AF analysis should be performed in amniodye test-negative women.
Microfluidic free-flow electrophoresis for proteomics-on-a-chip (2008)

A new free-flow electrophoresis microchip with integrated permeable membranes was developed, and different substances were separated by free-flow zone electrophoresis, free-flow isoelectric focusing and free-flow field step electrophoresis. This chip contained a new type of membranes enabling a stable carrier flow with a perpendicular electrical current. Due to this chip configuration, the device performance and efficiency were superior to recently published alternative systems in terms of separation resolution and sample capacity. The results furthermore indicate that even better results are possible. Analytes were separated and focused within hundreds of milliseconds whereby only nanoliters of samples were consumed. In addition, a new sample steering method was demonstrated during free-flow zone electrophoresis, allowing the specific sorting of various components. As an alternative, a free-flow electrophoresis chip was developed with integrated platinum electrodes, whereby the generation of gas bubbles caused by electrolysis was successfully suppressed by chemical means. Gas bubbles generated by electrolysis are major concern in free-flow electrophoresis systems in general leading to distorted separation. Based on the results, a fourth free-flow chip was developed with an integrated surface plasmon resonance gold detection region. Although fabrication was successful, certain hurdles, in particular surface chemistry issues still remain to be overcome to perform separation and real-time detection of biological samples within this hyphenated micro device. A strategy for proteomics-on-a-chip was developed aiming at the separation of antigens that play a role in autoimmune diseases. In addition two new continuous flow microfluidic chips were developed allowing for continuous biochemical reactions of surface patterning applications. These devices could be of further interest in future, in particular in more complex analytical systems related to proteomics-on-a-chip.
808-nm diode-pumped continuous-wave Tm:GdVO_4 laser at room temperature (2005)

A high-quality gadolinium vanadate (GdVO4) crystal with 7-at. % thulium as the starting material was grown by the Czochralski technique. The measured absorption spectra exhibited sufficient absorption coefficients for laser diodes (LDs) for neodymium laser pumping: 6.0 cm(-1) for pi polarization and 6.2 cm(-1) for sigma polarization at 808 nm. Laser oscillation was carried out with single-stripe 808-nm LDs in an end-pumping configuration. A slope efficiency of 28% and a threshold of 750 mW were exhibited with respect to the absorbed pump power. An output power of 420 mW was achieved at an absorbed power of 2.4 W. It was demonstrated that Tm:GdVO4 is a useful material for 2-microm lasers, particularly in a compact LD-pumped system.
An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer (2006)

Animal viruses (e.g., lentiviruses and herpesviruses) use transcriptional positive feedback (i.e., transactivation) to regulate their gene expression. But positive-feedback circuits are inherently unstable when turned off, which presents a particular dilemma for latent viruses that lack transcriptional repressor motifs. Here we show that a dissipative feedback resistor, composed of enzymatic interconversion of the transactivator, converts transactivation circuits into excitable systems that generate transient pulses of expression, which decay to zero. We use HIV-1 as a model system and analyze single-cell expression kinetics to explore whether the HIV-1 transactivator of transcription (Tat) uses a resistor to shut off transactivation. The Tat feedback circuit was found to lack bi-stability and Tat self-cooperativity but exhibited a pulse of activity upon transactivation, all in agreement with the feedback resistor model. Guided by a mathematical model, biochemical and genetic perturbation of the suspected Tat feedback resistor altered the circuit's stability and reduced susceptibility to molecular noise, in agreement with model predictions. We propose that the feedback resistor is a necessary, but possibly not sufficient, condition for turning off noisy transactivation circuits lacking a repressor motif (e.g., HIV-1 Tat). Feedback resistors may be a paradigm for examining other auto-regulatory circuits and may inform upon how viral latency is established, maintained, and broken.
Architectures with pictures (1992)

Wired and wireless models of software architecture are proposed as unifying models spanning a wide range of software, including object-oriented and real-time software. The models are defined and explained from a common conceptual viewpoint, with the aid of pictures, including concepts such as contracts, roles, wirings, and timethreads. Wired architectures have fixed point-to-point communication paths between components. Wireless architectures have no fixed point-to-point communication paths, but allow temporary, communication paths to be established dynamically. The paper uses a vanilla visual notation to communicate the concepts that is compatible with a wide variety of richer notations. Our central objective is to contribute to reconciling apparently-different ways of conceptualizing software architectures.
Effects of a dietary Aspergillus oryzae extract containing α-amylase activity on performance and carcass characteristics of finishing beef cattle (2007)

Three experiments were conducted to examine the effects of an Aspergillus oryzae extract containing alpha-amylase activity on performance and carcass characteristics of finishing beef cattle. In Exp. 1, 120 crossbred steers were used in a randomized complete block design to evaluate the effects of roughage source (alfalfa hay vs. cottonseed hulls) and supplemental alpha-amylase at 950 dextrinizing units (DU)/kg of DM. Significant roughage source x alpha-amylase interactions (P < 0.05) were observed for performance. In steers fed cottonseed hulls, supplemental alpha-amylase increased ADG through d 28 and 112 and tended (P < 0.15) to increase ADG in all other periods. The increases in ADG were related to increased DMI and efficiency of gain during the initial 28-d period but were primarily related to increased DMI as the feeding period progressed. Supplemental alpha-amylase increased (P = 0.02) the LM area across both roughage sources. In Exp. 2, 96 crossbred heifers were used in a randomized complete block design with a 2 x 3 factorial arrangement of treatments to evaluate the effects of corn processing (dry cracked vs. high moisture) and supplemental alpha-amylase concentration (0, 580, or 1,160 DU/kg of DM). Alpha-amylase supplementation increased DMI (P = 0.05) and ADG (P = 0.03) during the initial 28 d on feed and carcass-adjusted ADG (P = 0.04) across corn processing methods. Longissimus muscle area was greatest (quadratic effect, P = 0.04), and yield grade was least (quadratic effect, P = 0.02) in heifers fed 580 DU of alpha-amylase/kg of DM across corn processing methods. In Exp. 3, 56 crossbred steers were used in a randomized complete block design to evaluate the effects of supplemental alpha-amylase (930 DU/kg of DM) on performance when DMI was restricted to yield a programmed ADG. Alpha-amylase supplementation did not affect performance when DMI was restricted. We conclude that dietary alpha-amylase supplementation of finishing beef diets may result in increased ADG through increased DMI under certain dietary conditions and that further research is warranted to explain its mode of action and interactions with dietary ingredients.
Alectinib versus Crizotinib in Untreated <i>ALK</i>-Positive Non–Small-Cell Lung Cancer (2017)

As compared with crizotinib, alectinib showed superior efficacy and lower toxicity in primary treatment of ALK-positive NSCLC. (Funded by F. Hoffmann-La Roche; ALEX ClinicalTrials.gov number, NCT02075840 .).
3D integration of ultra-thin functional devices inside standard multilayer flex laminates (2009)

Nowadays, more and more wearable electronic systems are being realized on flexible substrates. Main limiting factor for the mechanical flexibility of those wearable systems are typically the rigid components - especially the relatively large active components - mounted on top and bottom of the flex substrates. Integration of these active devices inside the flex multilayers will not only enable for a high degree of miniaturization but can also improve the total flexibility of the system. This paper now presents a technology for the 3D embedding of ultra-thin active components inside standard flex laminates. \nActive components are first thinned down to 20-25 mu m, and packaged as an Ultra-Thin Chip Pack-age (UTCP). These UTCP packages will serve as flexible interposer: all layers are so thin, that the whole package is even bendable. The limited total pack-age thickness of only 60 mu m makes them also suitable for lamination in between commercial flex panels, replacing for example the direct die integration. A fan-out metallization on the package facilitates easy testing before integration, solving the KGD issue, and can also relax the chip contact pitch, excluding the need for very precise placement and the use of expensive, fine-pitch flex substrates. \nThe technology is successfully demonstrated for the 3D-integration of a Texas Instrument MSP430 low-power microcontroller, inside the conventional double sided flex laminate of a wireless ECG system. The microcontrollers are first thinned down and UTCP pack-aged These pack-ages are then laminated in between the large panels of the flex multilayer stack and finally connected to the different layers of the flex board by metallized through-hole interconnects. \nThe thinning down, the UTCP pack-aging and the 3D-integration inside the commercial flex panels did not have any affect on the functionality of the TI microcontroller. Smaller SMD's were finally mounted on top and bottom of the integrated device.
Kinetics of Nucleation, Growth, and Stabilization of Cobalt Oxide Nanoclusters (2003)

Metallic fragments, or metallomers (similar to the “mer”-based nomenclature for polymers), formed via the decomposition of organometallic complexes, are highly reactive, generating a nucleation and growth process that culminates in the formation of nanocrystals. In the absence of stabilizing molecules, the aggregation process is self-restricting mainly because of the decreasing mobility of the particles and their declining diffusional rates as a function of their increasing size. On the other hand, in the presence of a polymer in the reaction medium, the growing metallic particles are stabilized by the adsorption of the polymer chains onto their surfaces, thus lowering their surface energy and creating a barrier to further aggregation. Studies of the nucleation and aggregation kinetics of metallic particles formed from the decomposition of organometallic precursors have been used to shed light on the mechanism of their formation. In these studies, the rate of decomposition of the precursor organometallic complexes used has been deemed representative of the overall rate of the process. Moreover, it has implicitly been assumed that the formation kinetics of the metal nanoclusters directly mirrors the decomposition kinetics of the precursors. In this study, we attempt to decouple the kinetic characteristics of the various steps that comprise the overall nucleation and aggregation process for cobalt oxide nanoclusters. A combination of infrared and X-ray photoelectron spectroscopies, transmission electron microscopy, and dynamic light scattering is used to identify the individual contribution of each step to the overall mechanism of metal nanocluster formation.
Alternative Assessments for Sensory Integration Dysfunction (2000)

This article describes research designed to compare the results that were obtained from assessing 14 boys aged 5–11 years using two batteries of tests for the identification of sensory integration dysfunction. The results of tests commonly used in the United Kingdom were statistically and graphically compared with the results from the Southern California Sensory Integration Tests (SCSIT), which were used as a standard measure. The research indicated that both assessment protocols provide similar diagnostic information, except for the motor domain. The Movement Assessment Battery for Children provides information on the child's level of motor function, but does not provide information on motor planning and bilateral and sequencing ability that is equivalent to that provided by the SCSIT. Further areas of research are suggested.