gebhart/patrepeval huggingface dataset:
Metabolic Pathways of Type 2 Diabetes Intersection of Genetics, Transcriptomics, and Metabolite Profiling (2008)

<p>Type 2 diabetes is characterized by insufficient insulin secretion to maintain euglycemia in the setting of peripheral insulin resistance. The majority of insulin-resistant diabetics are obese, yet not all insulin-resistant obese individuals develop diabetes. This obesity/diabetes dichotomy suggests that genetic factors play a pivotal role in disease pathogenesis.</p><p>Gene mapping has identified genetic quantitative trait loci (QTL) influencing disease-related phenotypes. To uncover molecular pathways leading from genotype to clinical trait, we classify phenotypes in greater depth and identify QTL that influence combinations of physiological traits, mRNA levels, and metabolite abundance. A major challenge then becomes deciphering the causal interrelationships among correlated phenotypes. </p><p>In this dissertation, we develop methods for building causal direction into an undirected network by including QTLs for each phenotype. We then apply and validate these methods in an F2 intercross between the diabetes-resistant C57BL/6 leptinob/ob (B6ob/ob) and the diabetes-susceptible BTBR leptinob/ob (BTBRob/ob) mouse strains. We show that genomic analysis can be integrated with liver transcriptional and metabolite profiling data to construct causal networks for specific metabolic processes in liver. This causal network construction led to the discovery of a pathway by which glutamine induces Phosphoenolpyruvate carboxykinase (Pck1) expression.</p><p>To investigate glutamine induction of Pck1 in the context of diabetes, we perform mRNA expression analysis and metabolic profiling in liver of the parental strains. We find glutamine is decreased with obesity in both strains; in the diabetes-resistant B6 strain, liver Pck1 expression parallels glutamine abundance, but in the diabetes-susceptible BTBR strain, Pck1 is elevated with obesity. Follow-up in vitro studies indicate that α-ketoglutarate, which is elevated nearly two fold in the livers of BTBR relative to B6 mice in vivo, may mediate the glutamine effect. We hypothesize that hepatic Pck1 is regulated by glutamine abundance in the liver of B6 animals, but in the presence of high α-ketoglutarate, Pck1 becomes uncoupled from glutamine regulation in the livers of diabetes-susceptible BTBR mice.</p><p>Our method of causal network construction led to the discovery of glutamine induction of a key hepatic gluconeogenic enzyme, a pathway potentially disrupted in the diabetes-susceptible BTBR mouse. Future studies will include identifying hepatic mediators of the glutamine effect, and applying QTL-directed networks to multiple organs to ultimately define causal relationships between tissues involved in diabetes progression.</p>
Über die Geschwindigkeit der Sauerstoffentwickelung aus Chlorkalklösungen bei Gegenwart kleiner Mengen von Kobaltnitrat, und über den Einfluß verschiedener Verbindungen auf diese. Ein Beitrag zum Studium der Katalyse (1913)

Abstract 1. Kleine Mengen Co(NO 3 ) 2 beschleunigen sehr stark die Sauerstoffentwickelungsgeschwindigkeit aus Chlorkalklösungen, und die Beziehung zwischen Geschwindigkeit und Konzentration wurde gemessen.
From Identification to Identity Theft: Public Perceptions of Biometric Privacy Harms (2019)

Central to understanding biometric privacy is the question of biometric privacy harms. How much do people value biometric privacy, and what evils should biometric privacy laws seek to avert? This Article addresses these questions by surveying two nationally representative samples to determine what does, and does not, worry people in the context of biometrics. The results show that many people are deeply concerned about biometric privacy in the consumer context, that they are willing to sacrifice real benefits to preserve biometric privacy, and that those who are concerned with biometric privacy attribute their concern to many factors that are not directly related to data security, particularly public tracking. Further, people’s level of comfort with biometric data collection differs sharply depending on the uses to which the data will be put and not just on the type of data collected. These nuanced attitudes about biometric privacy are in sharp conflict with a purely data security approach to biometric harms, and therefore have substantial implications both for future legislative consideration as well as current standing litigation.
Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27 (2000)

Overexpression and activation of HER-2/neu, a proto-oncogene, play a pivotal role in cancer formation. Strong expression of HER-2/neu in cancers has been associated with poor prognosis. Reduced expression of p27(Kip1), a cyclin-dependent kinase inhibitor, correlates with poor clinical outcome in many types of carcinomas. Because many cancers with the overexpression of HER-2/neu overlap with those affected by reduced p27 expression, we studied the link between HER-2/neu oncogenic signals and p27 regulation. We found that down-regulation of p27 correlates with HER-2/neu overexpression. To address the molecular mechanism of this inverse correlation, we found that reduction of p27 is caused by enhanced ubiquitin-mediated degradation, and the HER-2/Grb2/MAPK pathway is involved in the decrease of p27 stability. Also, HER-2/neu activity causes mislocation of p27 and Jun activation domain-binding protein 1 (JAB1), an exporter of p27, into the cytoplasm, thereby facilitating p27 degradation. These results reveal that HER-2/neu signals reduce p27 stability and thus present potential points for therapeutic intervention in HER-2/neu-associated cancers.
Two-wavelength Talbot effect and its application for three-dimensional step-height measurement (2006)

The phenomenon of Talbot self-image shift by changing the wavelength of the illuminating light is described and demonstrated experimentally. A periodic grating is illuminated by light with wavelengths lambda1 and lambda2 generated by two lasers, and the Talbot self-images are recorded along the longitudinal direction at individual wavelengths. The Talbot self-image shift due to the change in the wavelength of light is implemented for the measurement of the three-dimensional step height of a large discontinuous object without any phase ambiguity problem. Fourier-transform fringe analysis was used to determine the maximum contrast of the high-visibility bands for the measurement of the step height of the object. The main advantages of the proposed system are nonmechanical scanning, high stability because of its common path geometry, compactness, and a wide range of measurement as compared to interferometric three- dimensional profilers.
Meteorological factors and Asian soybean rust epidemics: a systems approach and implications for risk assessment (2008)

Favorable meteorological and environmental conditions are critical components that affect Asian soybean rust (ASR), caused by Phakopsora pachyrhizi, the most damaging fungal disease of soybean. In this review, we used available knowledge on the effect of meteorological factors affecting the disease to construct a systems-based approach to understand the risk of ASR epidemics. The systems approach is based on a hierarchical framework where relevant environmental factors that affect the key stages of the ASR disease cycle are identified and this included both aerobiological and epidemiological components. The formal framework we used examined the following epidemic characteristics: spore release, spore dispersal, spore deposition, infection efficiency, latent period and spore production. It provided the ability to identify the most important meteorological-related factors along with relevant knowledge gaps from which the implications for disease forecasting were described. This is new information that can be used as a guide for further epidemiological research and especially to develop and improve upon both local and regional risk models.
A Comparison of Force Sensing Techniques for Planetary Manipulation (2006)

Five techniques for sensing forces with a manipulator are compared analytically and experimentally. The techniques compared are: a six-axis wrist force/torque sensor, joint torque sensors, link strain gauges, motor current sensors, and flexibility modeling. The accuracy and repeatability of each technique is quantified and compared. The relative complexity and the impact on flight design of each technique are also compared. The results presented can be used in a trade study for missions requiring manipulator force sensing capabilities
Enhanced Solubility of Hydrogen in CO<sub>2</sub>-Expanded Liquids (2007)

Vapor−liquid equilibrium (VLE) data for the systems CO2/H2/acetonitrile, CO2/H2/acetone, and CO2/H2/methanol were determined at 40 °C and 25, 60, and 90 bar. A variable volume view cell was used coupled with an online gas chromatograph. The solubility of H2 in expanded solvents was improved by the presence of CO2 but not significantly; the solubility is less than one can achieve with pure H2 at the same total pressure. Nevertheless, CO2 does improve H2 solubility in all three solvents at the conditions studied, even though the H2 solubility enhancement by CO2 is very modest. The Peng−Robinson equation of state predicted the ternary VLE remarkably well using only binary interaction parameters.
QSGD: Communication-Optimal Stochastic Gradient Descent, with Applications to Training Neural Networks (2016)

Parallel implementations of stochastic gradient descent (SGD) have received significant research attention, thanks to excellent scalability properties of this algorithm, and to its efficiency in the context of training deep neural networks. A fundamental barrier for parallelizing large-scale SGD is the fact that the cost of communicating the gradient updates between nodes can be very large. Consequently, lossy compression heuristics have been proposed, by which nodes only communicate quantized gradients. Although effective in practice, these heuristics do not always provably converge, and it is not clear whether they are optimal. In this paper, we propose Quantized SGD (QSGD), a family of compression schemes which allow the compression of gradient updates at each node, while guaranteeing convergence under standard assumptions. QSGD allows the user to trade off compression and convergence time: it can communicate a sublinear number of bits per iteration in the model dimension, and can achieve asymptotically optimal communication cost. We complement our theoretical results with empirical data, showing that QSGD can significantly reduce communication cost, while being competitive with standard uncompressed techniques on a variety of real tasks. In particular, experiments show that gradient quantization applied to training of deep neural networks for image classification and automated speech recognition can lead to significant reductions in communication cost, and end-to-end training time. For instance, on 16 GPUs, we are able to train a ResNet-152 network on ImageNet 1.8x faster to full accuracy. Of note, we show that there exist generic parameter settings under which all known network architectures preserve or slightly improve their full accuracy when using quantization.
Biochemical Studies on the Mechanism of Chemical and Physical Inactivation of Reovirus (1982)

SUMMARY We have examined the effects of heat and several chemical inactivating agents on the buoyant density, particle-associated polypeptides and ultrastructure of reovirus particles. Treatment at pH 11 removed polypeptide σl from the outer capsid of reovirus type 2 but not from type 1; resultant particles were unchanged in their buoyant density and morphology. Treatment of reovirus types 2 and 3 with 2.5 M-guanidine-HCl produced particles with unchanged polypeptide content but an increased buoyant density, and caused aggregation of type 3 but not type 2. Treatment with 1 % SDS removed polypeptide σ3 from both types 1 and 2 and increased the buoyant density of the virus particles. The outer capsid of SDS-treated virions was greatly altered and often indistinct. Treatment of type 3 with either 1% phenol or 33% ethanol produced particles that had a full complement of polypeptides, were unaltered in buoyant density, but were greatly aggregated. Thus, these inactivating agents affect reovirus particles in specific and distinct ways. The differential effects of such treatments can thus be used to study the structure and function of the reovirus capsid components.
Diagnosis of Transistor Shorts in Logic Test Environment (2006)

For deep-sub micron technology based LSIs, conventional stuck-at fault model is no longer sufficient for fault test and diagnosis. This paper presents a method of fault diagnosis for transistor shorts in combinational and full-scan circuits under logic test environment. Description of a short requires a very large number of physical parameters, and hence it is difficult, if not impossible, to describe precisely the behavior of transistor shorts. Therefore, two types of transistor short models were defined and algorithms to address the diagnostic problem were developed. The novelty of the algorithms is that they use conventional stuck-at fault simulation methodologies to diagnose transistor level shorts. Experiments were conducted on benchmark circuits to demonstrate the effectiveness of the method
Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in <i>Arabidopsis</i> (2014)

The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas (CRISPR-associated) system has emerged as a powerful tool for targeted gene editing in many organisms, including plants. However, all of the reported studies in plants focused on either transient systems or the first generation after the CRISPR/Cas system was stably transformed into plants. In this study we examined several plant generations with seven genes at 12 different target sites to determine the patterns, efficiency, specificity, and heritability of CRISPR/Cas-induced gene mutations or corrections in Arabidopsis. The proportion of plants bearing any mutations (chimeric, heterozygous, biallelic, or homozygous) was 71.2% at T1, 58.3% at T2, and 79.4% at T3 generations. CRISPR/Cas-induced mutations were predominantly 1 bp insertion and short deletions. Gene modifications detected in T1 plants occurred mostly in somatic cells, and consequently there were no T1 plants that were homozygous for a gene modification event. In contrast, ∼22% of T2 plants were found to be homozygous for a modified gene. All homozygotes were stable to the next generation, without any new modifications at the target sites. There was no indication of any off-target mutations by examining the target sites and sequences highly homologous to the target sites and by in-depth whole-genome sequencing. Together our results show that the CRISPR/Cas system is a useful tool for generating versatile and heritable modifications specifically at target genes in plants.
Comparison of Wireless Standards-Setting --United States Versus Europe (2001)

When decisions about developing standards are left to individual firms, there are many advantages including a flexible response to market evolution, accommodation to rapid technology change, and avoidance of costly coordination. However, the market process does not necessarily lead to compatible standards, especially when there is no clear market dominator. Standards Institutions generally facilitate better communication among market participants, which may discourage early and/or primitive incompatible standards to emerge in the market. However, expenditures on institutional standards-setting can lead to diminishing returns, or even be counter-productive because institutional standards usually take longer to produce and are slower to respond to technology development. Government agencies can specify compulsory standards to avoid incompatibility. In addition, governments can tie their policy on standardization closely with their industrial, trade, and/or regulatory policies. However, many exogenous factors handicap a government's effective involvement. Government often fails to respond to the dynamics of technology development and consumer demand, and to pick up the "right technology". This study first discusses why two different models have emerged in the two regions. It then examines outcomes and implications of the two models, including impacts on domestic service deployment, global trade competition, technology innovations, and strategies of multinational corporations. The goal is to conduct an empirical comparison between the two contrasting models.
Cerebellar cortex: its simulation and the relevance of Marr’s theory (1992)

Marr's theory of the cerebellar cortex as an associative learning device is one of the best examples of a theory that directly relates the function of a neural system to its neural structure. However, although he assigned a precise function to each of the identified cell types of the cerebellar cortex, many of the crucial aspects of the implementation of his theory remained unspecified. We attempted to resolve these difficulties by constructing a computer simulation which contained a direct representation of the 13,000 mossy fibres and the 200,000 granule cells associated with a single Purkinje cell of the cerebellar cortex, together with the supporting Golgi, basket and stellate cells. In this paper we present a detailed explanation of Marr's theory based upon an analogy between Marr's cerebellar model and an abstract model called the associative net. Although some of Marr's assumptions contravene neuroanatomical findings, we found that in general terms his conclusion that each Purkinje cell can learn to respond to a large number of different patterns of activity in the mossy fibres is substantially correct. However, we found that this system has a lower capacity and acts more stochastically than he envisaged. The biologically realistic simulated structure that we designed can be used to assess the computational capabilities of other network theories of the cerebellum.
(Advances in inorganic membranes) (1989)

The conference was an excellent initial forum for coordinating international communication about the rapidly emerging field of inorganic membranes. It was well organized and held in an excellent new conference facility. There were about 300 conferees representing 26 countries, including most of the best known researchers in the field. The quality of the papers was excellent. Many of then presented very new and sophisticated work at the cutting edge of the technology. In Europe and Japan there is a broad awareness of these technologies and techniques for fabricating membranes with a broad range of properties and potential commercial uses. In his opening plenary paper, J. Charpin, with the Commissariat a L'Energie Atomic (CEA) at Saclay, gave the CEA credit for creating the new generation of inorganic membranes through its technology transfer from their nuclear energy programs. I met and talked with most of the best known people in the field. Our paper was extremely well received. Jacques Gillot hardly spoke to me before the paper. After presenting the paper, he approached me everywhere I went. The visits to the two best known membrane laboratories in Europe were worth the trip alone. Professor Cot's lab in Montpellier is rather modest, but doing some interesting and sophisticated work. Professor Burggraaf's lab in Enschede, Netherlands is extremely well equipped and staffed (63 people), and I believe this lab is doing the most advanced work.
Effect of low intensity pulsed ultrasound (LIPUS) on bone healing around a titanium implant in the tibia of osteoporosis-induced rats (2011)

Osteoporosis is a major health problem in the elderly that involves changes in the properties of bone as well as impaired bone healing around a titanium implant in both humans and animals. This study examined effect of low intensity pulsed ultrasound (LIPUS) on the bone healing process around a titanium implant in osteoporosis-induced rats. Materials and Methods: Sixteen rats were divided into two groups. A control group with osteoporosis induced by removing both ovaries and an experimental group of rats that were applied with LIPUS after osteoporosis had been induced. A screw type titanium implant (diameter, 2.0 mm: length, 3.5 mm, Cowell-Medi, KOREA) was placed into the tibias of 16 rats. The control and experimental group contained 8 rats each. The rats were sacrificed at 1, 2, 4, and 8 weeks after implantation to examine the histopathology and immunochemistry. Results: The histopathology examination revealed earlier new bone formation in the experimental group than the control group. In particular, at 1 week after implantation, more new bone matrix and collagen were observed around the implant of the experimental group compared to the control group. Immunochemistry analysis showed that the level of OPG expression of the experimental group was higher in the early stages than in the control group. After 8 weeks, the levels of OPG expression were similar in both groups. The expression level of receptor activator of nuclear factor kB ligand (RANKL) was stronger in the experimental group than the control group. After 4 weeks, the level of RANKL expression was similar in both groups. Conclusion: These results suggest that the application of LIPUS to implantation can promote bone healing around titanium in osteoporosis animals.
Ethylene regulation of gene expression in carrots (1982)

The respiration of carrot (Daucus carota L.) roots is stimulated by ethylene. Polyribosomes were shown to proliferate concomitantly with the increase in respiration, and the extent of polyribosome augmentation was closely correlated to the amount of respiratory stimulation. In addition to the increase in quantity, ethylene caused a 2-fold increase in the average polyribosome size, suggesting tighter packing of ribosomes on RNA. In vitro translation of carrot polyadenylylated RNA with the rabbit reticulocyte lysate system followed by electrophoresis of the resulting translation products showed that ethylene treatment results in the appearance of new mRNAs.
THE JACOBSEN REACTION. V<sup>*</sup> (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE JACOBSEN REACTION. V*CLARENCE L. MOYLE and LEE IRVIN SMITHCite this: J. Org. Chem. 1937, 02, 1, 112–137Publication Date (Print):March 1, 1937Publication History Published online1 May 2002Published inissue 1 March 1937https://pubs.acs.org/doi/10.1021/jo01224a012https://doi.org/10.1021/jo01224a012research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts