gebhart/patrepeval huggingface dataset:
Scientists Pinpoint a Protein Critical to the Function of the Ebola Virus (2001)

The paper presents the use of dual energy X-ray absorptiometry for selecting patients with high risk of proximal femur fracture. A group of 63 patients with fracture has been compared with a group of 306 patients who fell down but did not sustain a fracture, all individuals aged over 60. Most significant bone density decrease (p < 0.001) presented as Z indices related to young population was found in all three examined areas of the proximal femur. The difference between the groups ranged between 1.62 to 2.19 SD depending on the area and the sex. Threshold values for ZYA have been established. For the femoral neck it was -1.3 SD, for Ward's triangle -1.5 SD and for trochanteric area -0.4 SD.
Determination of sub-PPM amounts of boron in solutions by means of solid state track detectors (1983)

In the method described, small droplets of the solution to be analysed are applied to the detector. After neutron irradiation and etching, 10B can be determined in concentrations well below 0.1 mu g ml-1 by optoelectronic evaluation of the tracks formed. Less than 0.1 ng 10B is required for analysis. The method meets the demands set by the preparation of B-labelled monoclonal antibodies.
Chronic Urinary Tract Infection Due to <i>Candida utilis</i> (1999)

An elderly male was seen at an outpatient urology clinic over a period of 3 years with repeat urine specimens containing 10(4) to 10(5) CFU of a "Candida species, not C. albicans." The urine specimens were described as infected due to the presence of pyuria, but no antifungal therapy was administered. On two occasions, the patient presented to the emergency room and urine specimens were sent to the clinical microbiology laboratory. On both occasions, a yeast was isolated at concentrations of >10(5) CFU/ml. The organism was identified as the anamorphic yeast Candida utilis (teleomorph: Pichia jadinii) by conventional methods. Molecular methods, including karyotyping and restriction enzyme analysis, confirmed that the isolates were identical and were C. utilis. The patient developed benign prostatic hypertrophy and chronic obstructive pulmonary disease during the 3-year course. This report is the first demonstration of the isolation of the industrially important yeast C. utilis from a urinary tract infection. In the present case, the organism was associated with chronic, symptomatic disease. The significance of this unusual, low-virulence isolate from a case of urinary tract infection is discussed.
Complex Learning in Bio-plausible Memristive Networks (2015)

The emerging memristor-based neuromorphic engineering promises an efficient computing paradigm. However, the lack of both internal dynamics in the previous feedforward memristive networks and efficient learning algorithms in recurrent networks, fundamentally limits the learning ability of existing systems. In this work, we propose a framework to support complex learning functions by introducing dedicated learning algorithms to a bio-plausible recurrent memristive network with internal dynamics. We fabricate iron oxide memristor-based synapses, with well controllable plasticity and a wide dynamic range of excitatory/inhibitory connection weights, to build the network. To adaptively modify the synaptic weights, the comprehensive recursive least-squares (RLS) learning algorithm is introduced. Based on the proposed framework, the learning of various timing patterns and a complex spatiotemporal pattern of human motor is demonstrated. This work paves a new way to explore the brain-inspired complex learning in neuromorphic systems.
Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. (1998)

Seventeen separate mitochondrial hot spot mutations in a 100-bp target sequence (mitochondrial bp 10,030-10,130) were detected and measured in bronchial epithelial cell samples isolated from smokers and nonsmokers. Among the individuals sampled were three pairs of monozygotic twins in which one twin had never smoked and had a nonsmoking spouse, and the other had a smoking history of >10 pack-years. Individual point mutations present at frequencies as low as 10(-6) were detected. Partially denaturing electrophoresis was used to separate mutant from nonmutant sequences on the basis of their melting temperatures, and the target sequence was subsequently amplified via high-fidelity PCR with Pfu DNA polymerase. Tests were performed to determine whether mismatch intermediates or DNA adducts present in the cellular DNA were converted to mutants during PCR. Hot spot mutations were clearly observed in bronchial epithelial cells, and the same hot spots were observed consistently in different samples. Significant numerical variability in the mutant fractions for individual mutants was observed among samples and are ascribed to unequal mitochondrial segregation in stem and transition cells. The mutational spectra in smokers' samples did not differ significantly from the mutational spectra in nonsmokers' samples for this 100 bp of mitochondrial DNA. No smoking-specific hot spots were detected. The overall mutant fractions in smokers' samples were not elevated compared to those of nonsmokers. As much variability was observed between two samples from the same individual's lung as between a sample from a smoker and a sample from a nonsmoker. These findings demonstrate that inhaled tobacco smoke does not induce prominent point mutations in this 100-bp target mitochondrial sequence in smokers' bronchial epithelial cells. Endogenous factors (e.g., DNA replication errors or DNA damage by endogenous reactive chemicals) are suggested to be more likely to represent the most important contributors to mitochondrial mutagenesis.
ChemInform Abstract: Mechanochemistry: the Varied Applications of Mechanical Bond‐breaking (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Robust Joint Image Reconstruction from Color and Monochrome Cameras (2020)

Recent years have seen an explosion of the number of camera modules integrated into individual consumer mobile devices, including configurations that contain multiple different types of image sensors. One popular configuration is to combine an RGB camera for color imaging with a monochrome camera that has improved performance in low-light settings, as well as some sensitivity in the infrared. In this work we introduce a method to combine simultaneously captured images from such a two-camera stereo system to generate a high-quality, noise reduced color image. To do so, pixel-topixel alignment has to be constructed between the two captured monochrome and color images, which however, is prone to artifacts due to parallax. The joint image reconstruction is made robust by introducing a novel artifact-robust optimization formulation. We provide extensive experimental results based on the two-camera configuration of a commercially available cell phone.
Na Conductance Kinetics in the Low-Frequency Impedance of Isolated Snail Neurons (1986)

The complex impedance of isolated single neurons of Helix aspersa (snail) was measured at low frequencies (0.25-100 Hz) with a combination of a suction electrode for applying current and a microelectrode for measuring potential response. A repetitive, Fourier-synthesized signal superposed as a small perturbation (0.2 nA rms) on step current clamps was used in conjunction with Fourier transform techniques to obtain high-resolution impedance data 1 s after a step. The membrane capacitance of an 80 Ωm diameter cell, measured in the frequency range 2.5-1000 Hz after suppression of ion conduction, was 1.8 nF and had a constant phase angle of about -69°. The resting (-50 mV) extrapolated zero-frequency resistance, before suppression of conduction in the same cell, of a predominantly Na-conducting membrane was about 5 MΩ. Linear ion-conduction parameters were estimated directly by fitting an admittance model, based on the linearized Hodgkin-Huxley equations with a constant-phase-angle capacitance, to the reciprocal of the impedance data. The natural frequencies of Na activation and inactivation processes for small depolarizations (10-20 mV from rest potential) were determined to be 23-28 Hz (Tm = 7-5.7 ms) and 2.5-1.8 Hz (Th = 64-88 ms), respectively. These values are more than an order greater than the corresponding relaxation times of Na channels in the squid axon.
Centralized Pan-European Survey on the Undertreatment of Hypercholesterolemia in Patients Using Lipid Lowering Drugs–The CEPHEUS-Greece Survey (2010)

Surveys evaluating plasma lipid goal attainment in patients with coronary heart disease (CHD) show that hypercholesterolemia is inadequately treated. CEPHEUS (CEntralized Pan-European survey on tHE Undertreatment of hypercholeSterolemia)-Greece was part of a European multicenter, cross-sectional survey to evaluate the proportion of patients on lipid-lowering drugs (LLDs) for >or=3 months, without dose modifications for at least 6 weeks, who reach their low-density lipoprotein-cholesterol (LDL-C) target. A total of 1321 Greek patients comprised the full analysis set (FAS); 28% were smokers, while 60.7%, 35.4%, 32.1%, and 25.1% had a history of hypertension, CHD, metabolic syndrome, and diabetes mellitus, respectively; 49.7% of the study population reached the Third Joint European Task Force (TJETF) LDL-C goals and 49.3% achieved the 2004-updated National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) targets. Hypercholesterolemia is suboptimally managed in Greece, with almost 50% of patients on LLDs not reaching the LDL-C target.
Large-area bow-free n<sup>+</sup>GaN templates by HVPE for LEDs (2014)

The economic and energy efficiency promise of solid state lighting drive a continuous need to reduce the cost and improve the efficiency of visible LEDs. Current III-N LED manufacturing is dominated by non-native substrate approaches which result in strained epitaxial films, high dislocation density in the buffer and device active regions, and large epiwafer bow, which together present major limitations in terms of LED device yield, performance, and cost. Large area sapphire substrates (6”, 8”, and beyond) are becoming available and present cost reduction potential yet they are even more vulnerable to strain and bow related issues. We present a novel approach to realizing a zero-bow relativelythick GaN on sapphire template that can be made at essentially any diameter and which bodes well for improved device yield, performance, and cost. The elimination of bow is achieved through a simple cost-effective stress balancing technique involving backside deposition. The result is a large area GaN template which is flat at all temperatures and which has 10× lower dislocation density than current GaN buffers. We report on the properties of these templates and provide device data for LED structures grown thereon.
Neuropathologic changes in Alzheimer's disease. (2003)

Alzheimer's disease is characterized by degenerative changes in a variety of neurotransmitter systems. These include alterations in the function of the monoaminergic neural systems that release glutamate, norepinephrine, and serotonin as well as a few neuropeptide-containing systems. Alzheimer's disease is also characterized by degenerative changes in selected brain regions, including the temporal and parietal lobes and restricted regions within the frontal cortex and cingulate gyrus. The degeneration of these systems may underlie specific aspects of the dementia associated with Alzheimer's disease. A major problem in Alzheimer's disease research today is that none of the current hypothesized mechanisms are able to explain the cellular and regional distribution pattern that characterizes the neuropathology of Alzheimer's disease. This article summarizes the nature and extent of the changes associated with neural systems, possible treatment approaches, and a potential mechanism involving chronic neuroinflammation to explain the pattern of neuropathologic changes in Alzheimer's disease.
The Signaling Effects of the US Food and Drug Administration Fast‐Track Designation (2016)

Pharmaceutical firms are reluctant to disclose proprietary information about a drug's likelihood of approval by the U.S. Food and Drug Administration (FDA) for fear of losing their competitive advantage. Instead, firms may use signals, like the FDA fast‐track designation, to indicate to investors the likelihood of a drug's approval. This analysis uses an event study methodology, with stock and market data from the Center for Research in Security Prices. The results show that the fast‐track designation is a strong, positive signal to investors (1998–2015), but its strength has markedly decreased over time. Results also show that the signal is strongest for the smallest firms. Copyright © 2016 John Wiley & Sons, Ltd.
Adiabatic cycle analysis for the valved thermal compressor (1979)

The performance of Stirling cycle-based heat engines is frequently estimated using an integral analysis. In such an analysis the expressions used for cycle heat interactions and system output generally must assume isothermal processes in the working spaces in order to permit integration. It is shown in this paper that, for the special case of the Stirling cycle-based valved thermal compressor, closed-form expressions for cycle heat interactions and volumetric efficiency can be also derived assuming adiabatic processes. The analysis also provides closed form expressions for gas temperature in the working spaces as a function of position in the cycle. Since real cycle processes lie between the limiting adiabatic and isothermal models, the availability of both adiabatic and isothermal analysis permits the true cycle heat to be either bracketed or conservatively estimated using the integral technique, as opposed to the systematically optimistic prediction obtained when ideal isothermal processes are assumed. The quantitative difference between the predictions of the two models is examined by means of a numerical example.
Changes in the Cellular Energy State Affect the Activity of the Bacterial Phosphotransferase System (1996)

The effect of different cellular free-energy states on the uptake of methyl alpha-D-glucopyranoside, an analogue of glucose, by the Escherichia coli phosphoenolpyruvate:carbohydrate phosphotransferase system was investigated. The intracellular [ATP]/[ADP] ratio was varied by changing the expression of the atp operon, which codes for the H+-ATPase, or by adding an uncoupler of oxidative phosphorylation or an inhibitor of respiration. Corresponding initial phosphotransferase uptake rates were determined using an improved uptake assay that works with growing cells in steady state. The results show that the initial uptake rate was decreased under conditions of lowered intracellular [ATP]/[ADP] ratios, irrespective of which method was used to change the cellular energy state. When either the expression of the atp operon was changed or 2,4-dinitrophenol was added to wild-type cells, the relationship between initial phosphotransferase uptake rate and the logarithm of the [ATP]/[ADP] ratio was approximately linear. These results suggest that the cellular free-energy state, as reflected in the intracellular [ATPI]/[ADP] ratio, plays an important role in regulating the activity of the phosphotransferase system.
Quantifiable Interactivity of Malicious URLs and the Social Media Ecosystem (2020)

Online social network (OSN) users are increasingly interacting with each other via articles, comments, and responses. When access control mechanisms are weak or absent, OSNs are perceived by attackers as rich environments for influencing public opinions via fake news posts or influencing commercial transactions via practices such as phishing. This has led to a body of research looking at potential ways to predict OSN user behavior using social science concepts such as conformity and the bandwagon effect. In this paper, we address the question of how social recommendation systems affect the occurrence of malicious URLs on Facebook, based on the assumption that there are no differences among recommendation systems in terms of delivering either legitimate or harmful information to users. Next, we use temporal features to build a prediction framework with >75% accuracy to predict increases in certain user group behaviors. Our effort involves the demarcation of URL classes, from malicious URLs viewed as causing significant damage to annoying spam messages and advertisements. We offer this analysis to better understand OSN user sensors reactions to various categories of malicious URLs in order to mitigate their effects.
Sensors and actuators based on surface acoustic waves propagating along solid–liquid interfaces (2008)

The propagation of surface acoustic waves (SAWs) along solid?liquid interfaces depends sensitively on the properties of the liquid covering the solid surface and may result in a momentum transfer into the liquid and thus a propulsion effect via acoustic streaming. This review gives an overview of the design of different SAW devices used for the sensing of liquids and the basic mechanisms of the interaction of SAWs with overlaying liquids. In addition, applications of devices based on these phenomena with respect to touch sensing and the measurement of liquid properties such as density, viscosity or the composition of mixed liquids are described, including microfabricated as well as macroscopic devices made from non-piezoelectric materials. With respect to the rapidly growing field of acoustic streaming applications, recent developments in the movement of nanolitre droplets on a single piezoelectric chip, the rather macroscopic approaches to the acoustic pumping of liquids in channels and recent attempts at numerical simulations of acoustic streaming are reported.
Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels (2013)

A chlorinated coumarin-hemicyanine dye with three potential reaction sites was exploited as fluorescent probe for biothiols. The Cys-induced substitution-rearrangement-cyclization, Hcy-induced substitution-rearrangement, and GSH-induced substitution-cyclizatioin cascades lead to the corresponding amino-coumarin, amino-coumarin-hemicyanine, thiol-coumarin with distinct photophysical properties, enabling Cys and GSH to be selectively detected from different emission channels at two different excitation wavelengths.
Influence of Rotor Skew in Induction Type Bearingless Motor (2012)

A prototype induction type bearingless motor has been developed with 4-axis active position regulation. In the developed motor, a problem of serious axial oscillation is observed during high acceleration and deceleration of shaft rotation. In the worst case, the shaft touched down and magnetic suspension was not possible. In this paper, the cause of the axial oscillation is presented. The axial shaft oscillation is shown to be caused by the skew of rotor conductors. One possible solution has been proposed and its effectiveness is verified in a prototype bearingless motor.
ANTIOXIDANT ACTIVITY OF ROSEMARY AND SAGE EXTRACTS IN RAPESEED OIL (2001)

ABSTRACT Rosemary and sage leaves were extracted with hexane, acetone, ethyl acetate and ethanol. Yields of extracts and of carnosic acid contents were higher in solvents of medium polarity. Both carnosic acid and carnosol showed medium activity in deodorized rapeseed oil, about the same as that of butylated hydroxyanisole. Carnosic acid was moderately more active than carnosol, and the resulting oxidative stability of extracts was correlated with the content of carnosic acid, but not with the content of carnosol. The antioxidant activity was about the same in rapeseed oil as in sunflower oil, but substantially lower than that in lard. Antioxidant activities, expressed as protection factors, were higher under Schaal oven test conditions at 40 or 60C than when determined in Oxipres at 100C. The dependence of the concentration of antioxidants and the protection factor showed similar negative exponential relations in all tests.
Protective effects of felbamate against hypoxia in the rat hippocampal slice. (1992)

In this model of hypoxia, felbamate provided neuroprotection against hypoxia at concentrations similar to serum felbamate levels currently being used in human clinical epilepsy trials.
Off-label use of atypical antipsychotics in personality disorders (2011)

There is some evidence that atypical antipsychotics are effective for treating symptom domains in personality disorders, in particular psychotic-like symptoms, impulsivity, aggression and anger. There is no evidence that they improve overall illness severity. Given the high rate of comorbidity between personality disorders and axis I disorders, atypical antipsychotics are best used when these symptom domains are prominent and there is a comorbid axis I condition for which an atypical antipsychotic is indicated.
Apolipoprotein A-IV attenuates oxidant-induced apoptosis in mitotic competent, undifferentiated cells by modulating intracellular glutathione redox balance (2005)

Oxidant-mediated modulation of the intracellular redox state affects the apoptotic cascade by altering the balance between cellular signals for survival and suicide. Apolipoprotein A-IV (Apo A-IV) is known to possess antioxidant-like activity. In the present study, we tested 1) whether Apo A-IV could influence redox-dependent apoptosis and, if so, 2) whether such an effect could be mediated by modulation of intracellular redox balance. Mitotic competent, undifferentiated PC-12 cells were incubated with either tert-butyl hydroperoxide (TBH) or diamide with or without preincubation with human Apo A-IV. Apo A-IV significantly decreased apoptosis produced by both TBH and diamide, and washout of A-IV before incubation with TBH and diamide did not eliminate its protective effect. Apo A-I had no such protective effect. The Apo A-IV effect was not blocked by D,L-buthionine-[S,R]-sulfoximine, but it was reversed by both dehydroisoandrosterone and transfection with an antisense oligodeoxynucleotide to glucose-6-phosphate dehydrogenase (G6PD). Apo A-IV abolished the transient, oxidant-induced rise in glutathione disulfide (GSSG) and cellular redox imbalance previously shown to initiate the apoptotic cascade. Apo A-IV had no effect on GSSG reductase activity, but it stimulated G6PD activity 10-fold. These results suggest a novel role for Apo A-IV in the regulation of intracellular glutathione redox balance and the modulation of redox-dependent apoptosis via stimulation of G6PD activity.
"Democracia y responsabilidad" XXXI Semana Social de España (1967)

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Crítica de Marx y Engels a la religión. II: nivel sociopolítico (1977)

Despues del aspecto economico, tratado en el articulo anterior (PROYECCION no 105), toca la vez a la critica de la religion a nivel politico; es decir, a la funcion social jugada por el cristianismo, por la Iglesia, como poder o como apoyo del poder, segun los primeros analisis del materialismo historico.