gebhart/patrepeval huggingface dataset:
Software Aging Prediction Based on Extreme Learning Machine (2013)

In the research on software aging and rejuvenation, one of the most important questions is when to trigger the rejuvenation action. And it is useful to predict the system resource utilization state efficiently for determining the rejuvenation time. In this paper, we propose software aging prediction model based on extreme learning machine (ELM) for a real VOD system. First, the data on the parameters of system resources and application server are collected. Then, the data is preprocessed by normalization and principal component analysis (PCA). Then, ELMs are constructed to model the extracted data series of systematic parameters. Finally, we get the predicted data of system resource by computing the sum of the outputs of these ELMs. Experiments show that the proposed software aging prediction method based on wavelet transform and ELM is superior to the artificial neural network (ANN) and support vector machine (SVM) in the aspects of prediction precision and efficiency. Based on the models employed here, software rejuvenation policies can be triggered by actual measurements. DOI:  http://dx.doi.org/10.11591/telkomnika.v11i11.3495 Full Text: PDF
Epigallocatechin‐3‐gallate selectively inhibits interleukin‐1 β‐induced activation of mitogen activated protein kinase subgroup c‐<i>Jun N</i>‐terminal kinase in human osteoarthritis chondrocytes (2002)

Activation of mitogen activated protein kinases (MAPK) is a critical event in pro-inflammatory cytokine-induced signaling cascade in synoviocytes and chondrocytes that lead to the production of several mediators of cartilage damage in an arthritic joint. Green tea (Camellia sinensis) is a widely consumed beverage and we earlier showed that polyphenols present in green tea (GTP) inhibit the development of inflammation and cartilage damage in an animal model of arthritis. In this study we evaluated the role of epigallocatechin-3-gallate (EGCG), a green tea polyphenol which mimics its anti-inflammatory effects, in modulating the IL-1beta-induced activation of MAPK's in human chondrocytes. We discovered that EGCG inhibited the IL-1beta-induced phosphorylation of c-Jun N-terminal kinase (JNK) isoforms, accumulation of phospho-c-Jun and DNA binding activity of AP-1 in osteoarthritis (OA) chondrocytes. Also IL-1beta, but not EGCG, induced the expression of JNK p46 without modulating the expression of JNK p54 in OA chondrocytes. In immunecomplex kinase assays, EGCG completely blocked the substrate phosphorylating activity of JNK but not of p38-MAPK. EGCG had no inhibitory effect on the activation of extracellular signal-regulated kinase p44/p42 (ERKp44/p42) or p38-MAPK in OA chondrocytes. EGCG or IL-1beta did not alter the total non-phosphorylated levels of either p38-MAPK or ERKp44/p42 in OA chondrocytes. These are novel findings and indicate that EGCG may be of potential benefit in inhibiting IL-1beta-induced catabolic effects in OA chondrocytes that are dependent on JNK activity.
Decomposed Methanol as a Fuel—A review (1991)

Abstract The use of decomposed methanol, i.e., hydrogen and carbon monoxide, in spark-ignition engines is reviewed. The emphasis is on onboard decomposition and the paper docs not deal with engines fueled by stored hydrogen. The paper concentrates mostly on the experimental work performed using catalytically decomposed methanol, where the methanol is used as a hydrogen carrier. The greatest potential for this type of engine, besides the low energy consumption, lies in the low emissions of nitrogen oxides when running at lean air/fuel ratios. An active and selective catalyst for the decomposition reaction is essential for the utilization of this concept. A literature review on catalyst investigations is included. Neat methanol engines arc not readily started at low ambient temperatures. The possibility of using decomposed methanol as a cold start fuel for methanol engines is reviewed. Decomposed methanol has been proposed as a fuel for gas turbines. A brief review of this subject is also included.
Influence of cephalosporins and iron on surface protein antigens of Klebsiella pneumoniae in vivo (1988)

The outer membrane protein (OMP) profiles of Klebsiella pneumoniae grown in a rabbit peritonitis model in the presence or absence of cephalosporins were investigated. Six high-molecular-weight OMPs (Mr 69,000 to 83,000) were induced under iron-depleted conditions in vitro. Three of these proteins (the 69,000-Mr protein [69K protein] and the 70K and 78K proteins) and trace amounts of the 73K and 75K proteins were induced in the OM of bacteria infecting the peritoneal cavity of rabbits. Addition of iron either to the growth medium in vitro or to the peritoneum in vivo repressed the expression of these proteins. Cephaloridine had no significant effect on the OMP profiles. An additional 56,000-Mr protein was observed in the OM of bacteria cultivated in vivo in the presence of CGP 17520 and also to a lesser extent in vivo under conditions of iron excess. A difference in recognition of OM antigens between cells grown in vitro and in vivo was observed by immunoblotting techniques. The 26K, 27.5K, and 28.5K antigens present in the OM of cells grown in vitro (but not in vivo) were recognized by antibodies raised against bacteria cultivated in vitro under conditions of iron depletion, but were not recognized by antisera raised against bacteria harvested directly from infections. Antisera raised against a nonencapsulated K. pneumoniae strain caused no agglutination of encapsulated K. pneumoniae grown in vivo in the absence of cephalosporins. Rapid agglutination was observed with this antiserum when the same encapsulated strain was grown in vivo in the presence of either cephalosporin, indicating less occlusion of critical antigens by the capsule.
Protection from distributed denial of service attacks using history-based IP filtering (2004)

In this paper, we introduce a practical scheme to defend against distributed denial of service (DDoS) attacks based on IP source address filtering. The edge router keeps a history of all the legitimate IP addresses which have previously appeared in the network. When the edge router is overloaded, this history is used to decide whether to admit an incoming Ip packet. Unlike other proposals to defend against DDoS attacks, our scheme works well during highly-distributed DDoS attacks, i.e., from a large number of sources. We present several heuristic methods to make the IP address database accurate and robust, and we present experimental results that demonstrate the effectiveness of our scheme in defending against highly-distributed DDoS attacks.
Acknowledgements (2018)

This book illuminates the personal experience of being at the centre of a media scandal. The existential level of that experience is highlighted by means of the application of ethnological and phenomenological perspectives to extensive empirical material drawn from a Swedish context. The questions raised and answered in this book include the following: How does the experience of being the protagonist in a media scandal affect a person's everyday life? What happens to routines, trust, and self-confidence? How does it change the basic settings of his or her lifeworld?The analysis also contributes new perspectives on the fusion between interpersonal communication that takes place face to face, such as gossip and rumours, and traditional news media in the course of a scandal. A scandal derives its momentum from the audiences, whose engagement in the moral story determines its dissemination and duration. The nature of that engagement also affects the protagonist in specific ways. Members of the public participate through traditional oral communication, one vital aspect of which is activity in digital, social forums. The author argues that gossip and rumour must be included in the idea of the media system if we are to be able to understand the formation and power of a media scandal, a contention which entails critiques of earlier research. Oral interpersonal communication does not disappear when new communication possibilities arise. Indeed, it may be invigorated by them. The term news legend is introduced, to capture the entanglement between traditional news-media storytelling and oral narrative.
Hole Transport Polymers with Improved Interfacial Contact to the Anode Material (2000)

New hole transport polymers have been prepared through copolymerization of a fluorinated triphenyl diamine derivative and trimethoxyvinylsilane. The modification with trimethoxysilane groups has resulted in materials which can be cross-linked through hydrolysis and are capable of forming covalent chemical bonds to oxidic surfaces. Organic light-emitting diodes containing these polymers show decreased operating voltages and enhanced operational stability due to improved interfacial contact between the hole transport layer and the anode.
Multicentre analytical evaluation of a new point-of-care system for the determination of cardiac and thromboembolic markers. (2010)

Due to its good analytical agreement with the laboratory methods and with its precursor device, the cobas h 232 system can be reliably used to support on-site decision making for cardiovascular patients in acute and non-acute settings.
Domains determining agonist selectivity in chimaeric VIP<sub>2</sub> (VPAC<sub>2</sub>)/PACAP (PAC<sub>1</sub>) receptors (1999)

1 The VPAC2 and PAC1 receptors are closely related members of the Group II G protein-coupled receptor family. At the VPAC2 receptor, VIP is equipotent to PACAP-38 in stimulating cyclic AMP production, whereas at the PAC1 receptor PACAP-38 is many fold more potent than VIP. In this study, domains which confer this selectivity were investigated by constructing four chimaeric receptors in which segments of the VPAC2 receptor were exchanged with the corresponding segment from the PAC1 receptor. 2 When expressed in COS 7 cells all the chimaeric receptors bound the common ligand [125I]PACAP-27 and produced cyclic AMP in response to agonists. 3 Relative selectivity for agonists was determined primarily by the amino terminal extracellular domain of the PAC1 receptor and the VPAC2 receptor. The interchange of other domains had little effect on the potency of PACAP-38 or PACAP-27. 4 For chimaeric constructs with a PAC1 receptor amino terminal domain, the substitution of increasing portions of the VPAC2 receptor decreased the potency of VIP yet increased that of helodermin. 5 This suggests that the interaction of VIP/helodermin but not PACAP with the PAC1 receptor may be influenced (and differentially so) by additional receptor domains.
ENEMIES OF CRITICAL THINKING: LESSONS FROM SOCIAL PSYCHOLOGY RESEARCH (2000)

This article examines changes in definitions of critical thinking. The most frequently cited definition of critical thinking points to the importance of belief, yet there is a dearth of research and theory in the reading arena concerning the construct of belief. Social psychologists have investigated belief, however, and have found evidence for two belief theories which are useful in understanding the complexity and problematic nature of teaching students to think critically. Two strands of social psychology research are explored. One strand provides evidence for the notion that people find it much easier to believe than to disbelieve. Theother strand of research suggests thatonce beliefsare formed, they are extremely resistant to change. How these tendencies are able operate simultaneously in humans, as well as implications for the development of critical thinking are discussed.
Dactyloquinones A and B, New Sesquiterpenoid Quinones from the Okinawan Marine Sponge <i>Dactylospongia</i> <i>e</i><i>legans</i> (2001)

Structurally unique new sesquiterpenoid quinones dactyloquinone A (1) and B (2), each possessing a dihydropyran moiety, were isolated from an Okinawan sponge Dactylospongia elegans, along with known sesquiterpenoid quinones. The structures of these compounds were determined by spectroscopic analysis.
Optimal switch in variable-speed pumping stations (2011)

This paper presents a kind of optimal switch method for variable-speed pumping stations with similar parallel pumps, and gives the minimum total power consumption. The optimal switch method is given for the changing total flow. The conclusion can also be applied to the energy optimization of other general devices.
Clinical detection of human probiotics and human pathogenic bacteria by using a novel high-throughput platform based on next generation sequencing (2014)

The proposed platform provides a relatively easy means of identifying a certain amount of bacteria and their species (including uncultivable pathogens) for clinical microbiology applications. That is, detecting how probiotics and pathogens inhabit humans and how affect their health can significantly contribute to develop a diagnosis and treatment method.
The design, development and performance characteristics of a fibre optic drag-force flow sensor (2000)

We present the design, development and performance characteristics of an optical fibre drag-force flow sensor to measure the speed and direction of fluid flow. Multidirectional fluid flow measurement is made possible by vectorial addition of the orthogonal flow components. The flow sensor comprises a fibre optic strain gauge developed by the authors, a cantilever-deflecting element made of rubber, and a drag element. The fibre optic strain gauge was designed and developed by inserting grooves into a multimode plastic optical fibre. As the fibre bends, the variation in the angle of the grooves causes an intensity modulation of the light transmitted through the fibre. The flow sensor has a repeatability of 0.3%, negligible hysteresis, and measures the wind velocity up to 30 m s-1 with a magnitude resolution of 1.4 m s-1 and a direction resolution of 5.9°. The flow sensor would be ideally suited for industrial and environmental applications.
Distributed topology control for Stable Path routing in multi-hop wireless networks (2010)

In this paper, we introduce the stable path topology control problem for link-state routing in mobile multi-hop networks. We formulate the topology control problem of selective link-state broadcast as a graph pruning problem with restricted local neighborhood information. We develop a multi-agent optimization framework where the decision policies of each agent are restricted to local policies on incident edges and independent of the policies of other agents. We show that under a condition called the positivity condition, these independent local policies preserve the stable routing paths globally. We then provide an efficient algorithm, which we call the Stable Path Topology Control algorithm, to compute this local policy that yields a pruned graph. Using simulations, we demonstrate that this algorithm, when used with the popular ETX metric, outperforms topology control mechanisms commonly used for Mobile Ad Hoc Networks.
Data Transmission over a Self-Contained Error Detection and Retransmission Channel (1964)

Error control of the detection and retransmission type requires an internal storage buffer when the data source cannot be stopped. With finite capacity there will be occasions when this internal buffer is overfilled. This paper investigates the relationships among the error statistics of the channel, the storage capacity of the buffer, the round-trip transmission delay and the bit rate from the source. It is shown that the process can be treated as a Markov chain. The solution algorithm is programmed for machine computation, and representative cases are solved numerically. For typical values selected from the telephone plant, it is found that buffer capacities of a few hundred bits would be adequate. The technique described should be useful for solving other problems in queueing theory.
Differential expression of metallopanstimulin/S27 ribosomal protein in melanocytic lesions of the skin (1997)

We have previously shown that human metallopanstimulin (MPS-1) is a ubiquitous 9.4-kDa multifunctional ribosomal S27/nuclear "zinc finger" protein which is expressed at high levels in a wide variety of cultured proliferating cells and tumor tissues, including melanoma. In the present study, we have examined the expression of the MPS-1 protein in various types of human benign and malignant melanocytic lesions of the skin. The expression of the MPS-1 protein was studied by immunohistochemistry using specific anti-MPS-1 antibodies. We found that in benign nevi, the staining is weak and in a gradient; most often, only type A melanocytes stain positive. The B and particularly the C types are negative. Remarkably, congenital nevi show a similar gradient staining of regular benign nevi, but in addition one example showed intensely positive dermal nodules adjacent to areas of negative melanocytes. In melanomas, the staining patterns for MPS-1 are more complex. While some melanomas stain evenly and intensely positive, others have remarkably variable expression of MPS-1. The scattered melanocytes migrating to the upper layers of the epidermis are usually intensely positive. In summary, benign lesions stain in an orderly pattern with staining gradients that correlate with the cellular differentiation of the nevi. Malignant melanomas have an erratic, often intense staining that also correlates with the disorderly growth of these neoplasms. These differential results indicate that the MPS-1 antigen is a useful marker for melanocytic lesions at the immunohistochemical level.
Telomerase components as a diagnostic tool in human oral lesions (1999)

Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to consist of 3 subunits. We assessed which component of telomerase best correlates with malignancy in order to study the possibilities for developing a new diagnostic marker. Telomerase activity was measured by a telomeric repeat amplification protocol (TRAP) assay, and the telomerase components hTR, hTRT-mRNA and TP1-mRNA were detected by the reverse transcriptase-polymerase chain reaction (RT-PCR). Twenty-five of 26 oral malignant lesions, 9 of 22 benign lesions and none of 19 normal control tissues exhibited distinct telomerase activity. hTR and TP1-mRNA expression levels were detected in all malignant lesions and normal control tissues and had no significant correlation with the telomerase activity results. In contrast, hTRT-mRNA expression was closely associated with telomerase activity. All lesions expressing hTRT were telomerase positive. In addition, some samples of dysplastic lesions, benign tumors, lichen planus and normal mucosa exhibiting poor telomerase activity revealed weak expression of hTRT. Expression levels of hTRT-mRNA positively correlated with clinical and pathological findings. Detection of hTRT-mRNA by RT-PCR appeared to be more sensitive for telomerase than measurement of telomerase activity by the TRAP assay. Detection of hTRT-mRNA may provide information useful in the diagnosis of oral malignancies.
Association of Epstein-Barr virus early antigen diffuse component and virus-specified DNA polymerase activity (1987)

The role of Epstein-Barr virus (EBV) early antigen diffuse component (EA-D) and its relationship with EBV DNA polymerase in EBV genome-carrying cells are unclear, EBV-specified DNA polymerase was purified in a sequential manner from Raji cells treated with phorbol-12,13-dibutyrate and n-butyrate by phosphocellulose, DEAE-cellulose, double-stranded DNA-cellulose, and blue Sepharose column chromatography. Four polypeptides with molecular masses of 110,000, 100,000, 55,000, and 49,000 daltons were found to be associated with EBV-specified DNA polymerase activity. A monoclonal antibody which could neutralize the EBV DNA polymerase activity was prepared and found to recognize 55,000- and 49,000-dalton polypeptides. An EA-D monoclonal antibody, R3 (G. R. Pearson, V. Vorman, B. Chase, T. Sculley, M. Hummel, and E. Kieff, J. Virol. 47:183-201, 1983), was also able to recognize these same two polypeptides associated with EBV DNA polymerase activity. It was concluded that EBV EA-D polypeptides, as identified by R3 monoclonal antibody, are critical components of EBV DNA polymerase.
Gamma irradiation preserves immunosuppressive potential and inhibits clonogenic capacity of human bone marrow‐derived mesenchymal stromal cells (2014)

Mesenchymal stromal cells (MSCs) are promising candidates for the treatment of graft-versus-host and autoimmune diseases. Here, by virtue of their immunosuppressive effects, they are discussed to exhibit inhibitory actions on various immune effector cells, including T lymphocytes that promote the underlying pathology. While it becomes apparent that MSCs exhibit their therapeutic effect in a transient manner, they are usually transplanted from third party donors into heavily immunocompromised patients. However, little is known about potential late complications of persisting third party MSCs in these patients. We therefore analysed the effect of gamma irradiation on the potency and proliferation of MSCs to elucidate an irradiation dose, which would allow inhibition of MSC proliferation while at the same time preserving their immunosuppressive function. Bone marrow-derived MSCs (BM-MSCs) were gamma-irradiated at increasing doses of 5, 10 and 30 Gy and subsequently assessed by colony formation unit (CFU)-assay, Annexin V-staining and in a mixed lymphocyte reaction, to assess colony growth, apoptosis and the immunosuppressive capacity, respectively. Complete loss of proliferative capacity measured by colony formation was observed after irradiation with a dose equal to or greater than 10 Gy. No significant decrease of viable cells was detected, as compared to non-irradiated BM-MSCs. Notably, irradiated BM-MSCs remained highly immunosuppressive in vitro for at least 5 days after irradiation. Gamma irradiation does not impair the immunosuppressive capacity of BM-MSCs in vitro and thus might increase the safety of MSC-based cell products in clinical applications.
Non-invasive EEG-metric based stress detection (2017)

Psychological stress is a vital parameter related to individual's health and cognitive performance which may affect emotions and professional efficiency. Regula stress profile generated can be used as neurofeedback for the clinical as personal assessment. This paper describes a method to detect mental stress level based on physiological parameters. In this method an electroencephalogram (EEG) parameter based binary stress classifier is developed which is validated through probabilistic stress profiler of differential stress inventory questionnaire. A non-invasive 9 channel EEG is used to extract physiological signal and an EEG-metric based cognitive state and workload outputs is generated for 41 healthy volunteers (37 males and 4 females, age; 24±5 years). All subjects were performed three simple tasks of closed eye, focusing vision on a red dot on center of dark screen and focusing on a white screen. Central tendencies (mean, median and mode) are extracted from of EEG-metric (sleep onset, distraction, low engagement, high engagement and cognitive states) as features. Either of the two classes as low stress or high stress are evaluated from probabilistic stress profiler of differential stress inventory and used as training output classes. A supervisory training of multiple layer perceptron based binary support vector machine classifier was used to detect stress class one by one. 40 subject's samples were used for training and interchanging one-by one 41th subject's stress class is determined from the designed classifier. Out of 41 subjects, stress level of 30 subjects is correctly identified.