gebhart/patrepeval huggingface dataset:
Enhancement of tyrosinase activity by macrocycles in the oxidation of p-cresol in organic solvents (1996)

The activity of tyrosinase, suspended in dry halogenated solvents, can be considerably increased upon the addition of macrocycles to the reaction medium.
A new HCBT with a partially etched collector (2005)

A novel horizontal current bipolar transistor (HCBT), suitable for the integration with the pillar-like MOSFETs, is processed with the reduced volume of the parasitic regions, achieved by the partial etching of the collector n-hill region and the self-protection of the p/sup +/ extrinsic base from tetramethyl ammonium hydroxide etch-back. The HCBT fabricated by a low-cost technology exhibits the cutoff frequency (f/sub T/) of 30.4 GHz, the maximum frequency of oscillations (f/sub max/) of 35GHz and the collector-emitter breakdown voltage (BV/sub CEO/) of 4.2 V, which are the highest f/sub T/ and the highest f/sub T/BV/sub CEO/ product among the lateral bipolar transistors (LBTs).
Photochemical Key Steps in the Synthesis of Surfactants from Furfural‐Derived Intermediates (2009)

Furfural is oxidized to 2[5H]-furanone by using hydrogen peroxide or to 5-hydroxy-2[5H]-furanone by using photo-oxygenation. An amine function is introduced by photochemically induced radical addition of tertiairy amines, some of which carry an n-alkyl side chain as hydrophobic moiety. These amines are produced from fatty aldehydes and cyclic secondary amines. The resulting adducts are transformed into amphoteric surfactants possessing an ammonium and a carboxylate function. Amphoteric (pK(N) and isoelectric point) and surfactant properties such as the critical micelle concentration and the adsorption efficiency are determined.
Sobre o papel (histórico) da crítica (2013)

Cristian Borges revê a recepção do filme Viagem ao fim do mundo, de Fernando Coni Campos, a partir de comentários de Jean-Claude Bernardet.
Context awareness by analysing accelerometer data (2002)

In this paper we describe continuing work being carried out as part of the Bristol Wearable Computing Initiative. We are researching processing techniques for data from accelerometers which enable the wearable computer to determine the user's activity. Techniques already employed by others have been explored and we propose new methods for analysing the data delivered by these devices. We try to minimise the number of devices needed by using a single X-Y accelerometer device. Using our techniques we have adapted our GPS based Tourist Guide application to vary its multimedia presentation according to the user's activity as well as location.
Herbicide-resistant crops as weeds in North America. (2007)

Abstract Growers have rapidly adopted transgenic herbicide-resistant (HR) crops, such as canola ( Brassica napus L.), soyabean [ Glycine max (L.) Merr.], maize ( Zea mays L.) and cotton ( Gossypium hirsutum L.), across North America (USA and Canada) since their commercial introduction in the 1990s. With their widespread cultivation, increasing attention is focused on management of HR volunteers in crops that follow in rotation. In this review, we describe the impact and management of HR crop volunteers in different agroecosystems in North America. The relative risks of planting HR crops and subsequent potential for volunteerism of these crops are assessed. HR volunteers are common weeds and the relative weediness depends on species, genotype, seed shatter prior to harvest and disbursement of seed at harvest, management practices, and environment. Chemical control options may be more limited if the crop volunteers are HR. There are generally no marked changes in volunteer weed problems associated with these crops, except in no-tillage systems when glyphosate (GLY) is used alone to control volunteers. The increasing use of GLY in North American cropping systems, spurred by increasing area and frequency in rotation of GLY - HR crops, may require increased alternative herbicide use or other novel tactics to control GLY-HR crop volunteers.
Cell cycle-regulated histone acetylation required for expression of the yeast HO gene (1999)

Expression of the yeast HO gene in late G1 of the cell cycle requires the SWI/SNF chromatin remodeling complex, the Gcn5p histone acetyltransferase, and two different sequence-specific transcriptional activators, Swi5p and Swi4p/Swi6p. We have used chromatin immunoprecipitation assays to investigate the role of each of these trans-acting factors in establishing a cell cycle-regulated domain of histone acetylation surrounding the HO upstream regulatory region. We detect a approximately 1-kb domain of H3 and H4 acetylation that is established in mid-G1, prior to and independent of HO transcription, which then declines with kinetics similar to inactivation of HO. This cell cycle burst of histone acetylation requires Gcn5p, SWI/SNF, and the Swi5p activator, but occurs in the absence of the Swi4p activator. We also find that inactivation of the Sin3p/Rpd3p deacetylase complex leads to a high level of acetylation at the HO locus throughout the cell cycle. We propose a sequential model for activation of HO in which the Swi5p-dependent recruitment of the Gcn5p acetyltransferase requires chromatin remodeling events by the SWI/SNF complex.
Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like‐1 (TLL‐1) proteinase (2009)

Bone morphogenetic protein-1 (BMP-1)/tolloid proteinases are fundamental to regulating dorsal ventral patterning and extracellular matrix deposition. In mammals there are four proteinases, the splice variants BMP-1 and mammalian tolloid (mTLD), and tolloid like-1 and -2 (TLL-1/2). BMP-1 has the highest catalytic activity and lacks three non-catalytic domains. We demonstrate that TLL-1, which has intermediate activity, forms a calcium-ion dependent dimer with monomers stacked side-by-side. In contrast, truncated TLL-1 molecules having the same shorter structure as BMP-1 are monomers and have improved activity towards their substrate chordin. The increased activity exceeds not only that of full-length TLL-1 but also BMP-1.
Cytochrome bd-typQ quinol oxidase in a mutant of Bacillus stearothermophilus deficient in caa3-type cytochrome c oxidase (1996)

Gram-positive thermophilic Bacillus species contain cytochrome caa3-type cytochrome c oxidase as a terminal oxidase in the respiratory chain. To identify alternative oxidases, we isolated B. stearothermophilus mutants defective in the caa3-type oxidase activity. One mutant contained little cytochrome a and had low cytochrome c oxidase activity. However, growth and the respiratory activity of membranes in the presence of NADH were close to normal, suggesting that the mutant contains an alternative electron transfer pathway. A novel oxidase was isolated from the membrane fraction of the mutant. The enzyme is a cytochrome bd-type quinol oxidase composed of two subunits of 52 and 40 kDa, whose N-terminal regions show sequence similarity to polypeptides of the bd-type oxidase from Escherichia coli and Azotobacter vinelandii. This is the first report of a bd-type terminal oxidase purified from a Gram-positive bacterium.
Pulsed laser technique application to liquid and gaseous flows and the scattering power of seed materials (1985)

Mie scattering computations have been performed for light scattered by small particles from a pulsed sheet of laser illumination and collected and imaged by a camera lens. From these computations the smallest particles that can be photographed in various fluid measurement situations, including air and water, have been determined in terms of system parameters such as laser power, light sheet geometry, f/No., and photographic film properties. The particle scattering requirements of the individual particle image mode and the speckle mode are compared.
Desmitis of the Accessory Ligament of the Equine Deep Digital Flexor Tendon: A Regenerative Approach (2013)

Background: Desmitis of the accessory ligament of the deep digital flexor tendon (ALDDFT) is a very common problem in different breeds of sport horses, with an inability to heal adequately after conservative therapy in many cases. However, the treatment of different kinds of tendon lesions with platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), or even tenogenic induced MSCs have been reported with promising results.
Multivariable and multirate self-tuning control: a distillation column case study (1991)

This paper is concerned with the evaluation of self-tuning control algorithms for the multivariable control of distillation columns. Effective distillation control remains a key concern of industry because of the high energy consumption associated with distillation processes. The results presented here are taken from a continuing programme of investigations aimed at improving distillation column control performance. The performance of several multi-variable self-tuning strategies is evaluated by online application to a pilot-scale binary distillation column which is subjected to disturbances of ±25% step changes in feed flow rate. The performance of the multivariable algorithms is compared with that achieved using conventional digital multiloop PI/PID control. The results have demonstrated that use of multivariable self-tuning control, in particular multirate-multivariable self-tuning control, can provide better regulatory performance for feed flow rate disturbances than can be achieved using a multiloop PI/PID strategy.
Consumer Holographic ROM Reader with Mastering and Replication Technology (2006)

A novel holographic ROM design allows a compact low-cost consumer drive with lensless readout in a 10 mm drive height. A two-step mastering method enables high-efficiency holographic masters for fast replication using planewave illuminations
Arabidopsis Phospholipase Dα1 Interacts with the Heterotrimeric G-protein α-Subunit through a Motif Analogous to the DRY Motif in G-protein-coupled Receptors (2004)

Phospholipase D (PLD) and heterotrimeric G-protein both play important, diverse roles in cellular regulation and signal transduction. Here we have determined the physical interaction between plant PLD and the only canonical alpha-subunit (Galpha) of the G-protein in Arabidopsis thaliana and the molecular basis for the interaction. PLDalpha1 expressed in either Escherichia coli or Arabidopsis was co-precipitated with Galpha. PLDalpha1 contains a sequence motif analogous to the G alpha-interacting DRY motif normally conserved in G-protein-coupled receptors. Mutation of the central Lys residue PLD(K564A) of this motif abolished the PLDalpha1-Galpha binding, whereas mutation of the two flanking residues PLD(E563A) and PLD(F565A) decreased the binding. Addition of Galpha to PLDalpha1 inhibited PLDalpha1 activity, whereas the PLD(K564A) mutation that disrupted the Galpha-PLDalpha1 binding abolished the inhibition. GTP relieved the Galpha inhibition of PLDalpha1 activity and also inhibited the binding between PLDalpha1 and Galpha. Meanwhile, the PLDalpha1-Galpha interaction stimulated the intrinsic GTPase activity of Galpha. Therefore, these results have demonstrated the direct binding between Galpha and PLDalpha1, identified the DRY motif on PLDalpha1 as the site for the interaction, and indicated that the interaction modulates reciprocally the activities of PLDalpha1 and Galpha.
Solution Phase Combinatorial Synthesis and Screening of Mini Libraries of Arylchalcones for Antibacterial Activity (2008)

The solution-phase combinatorial synthesis of aryl chalcones was studied by synthesizing a 6x4 array mini library. The mini libraries of chalcones were synthesized by condensation of 4-substituted acetophenones and various aryl/heteroaryl carbaldehydes. All the synthesized mini libraries were screened for antibacterial activity using serial dilution method. The mini-libraries 3{1a,2a–d}, 3{1b,2a–d}, 3{1a–f,2a} and 3{1a–f,2c}were found to be most active of the synthesized mini libraries. The common elements present in the identified pool of interest were used to individually synthesize four compounds which were individually subjected to antibacterial activity evaluation. The compound 3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one exhibited significant activity that was better than that of the other three compounds synthesized. The anti-bacterial activity of the identified hit was also found to be better than all mini-libraries, indicating utility of combinatorial synthesis and the assumption there in for lead identification.
국민의 노후생활에 대한 전망과 대책에 관한 연구 (1992)

본 연구는 비노인층 국민률이 예상하는 노후생활의 전망과 노후생활상의 욕구와 문제점 및 이에 대한 개인적인 대비책을 알아보기 위하여 국민연금 보험 가입자(18세-59세) 1,000명으로부터 회수된 질문지를 분석하였다. 비노인층의 대부분온 자신들의 노후에 적어도 의식주의 생계유지는 가능할 것으로 예상하고 자녀에게 의존하지 않으려는 경향을 보였다. 건강보호는...
Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors (2000)

Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse drug reaction characterized by a massive destruction of the epidermis. Immunohistological studies of skin biopsies of TEN showed infiltrates of predominantly CD8+ T lymphocytes even though other authors reported a prominent involvement of cells of the monocyte-macrophage lineage. The aim of this study was to characterize phenotypically and functionally the cells present in the cutaneous blister fluid of four patients with TEN. We first determined that lymphocytes were predominant in blister fluid obtained early, while monocytes/macrophages later became the most important population. We then showed that this lymphocyte population, mainly CD3+CD8+, corresponded to a peculiar cell subset as they expressed cutaneous leucocyte antigen, killer inhibitory receptors KIR/KAR and failed to express CD28 molecule. Functionally, we determined that blister T lymphocytes had a cytotoxic T lymphocyte (CTL)- and NK-like cytotoxicity. The role of this cytotoxic lymphocyte population present at the site of lesions during TEN remains to be understood.
Into the Manuscript Matrix: Middle Letters for Readers of a Middle Sort (2007)

If the architectural motifs in manuscripts such as the Sherborne Missal, Hours of Mary of Burgundy, and the Beaufort or Beauchamp Hours intimate that for medieval readers a book may bring forth an imaginary dimension—a productive cell I term the manuscript matrix—then the elementary building blocks of that quasi-verbal, quasi-visual realm would have to be the assembled letters of the alphabet. The notion that these elements of writing might constitute the essential components of a liminal realm is implicit in their use in the ceremony for consecrating churches, for there they found truly architectural spaces as otherworldly domains. Directions for the "alphabet ceremony" portion of the consecration service, which survive in many English pontificals dating from the tenth century onward, instruct the officiating bishop to trace two alphabets along intersecting diagonal paths of sand or ashes spread on the church floor.1 While the origins of this ceremony remain a mystery, the significance it held for medieval Christians is clear from surviving commentaries; for instance, in his Tractatus de dedicatione ecclesiae, Remigius of Auxerre (d. 908) acknowledges that the ritual looks like a childish game at first glance—"Quae res puerilis ludus videretur"—but then goes on to ask, "Quid autem per alphabetum, nisi initia et rudimenta doctrinae sacrae intelligi convenit?" [What is properly understood through the alphabet if not the beginnings and rudiments of the sacred teachings convenit?].2KeywordsImaginary WorldMiddle LetterNovice ReaderSuccessive LetterAlphabetical CharacterThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Regiospecific Synthesis of 2,3-Bisnaphthopyranyl Quinones Related to Conocurvone. Effect of Substituents on Palladium-Catalyzed Cross-Coupling of Organostannanes to Naphthopyranyl Hydroxyquinone Triflates (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTRegiospecific Synthesis of 2,3-Bisnaphthopyranyl Quinones Related to Conocurvone. Effect of Substituents on Palladium-Catalyzed Cross-Coupling of Organostannanes to Naphthopyranyl Hydroxyquinone TriflatesKenneth W. Stagliano and Helena C. MalinakovaView Author Information Department of Biological, Chemical and Physical Sciences, Illinois Institute of Technology, Chicago, Illinois 60616 Cite this: J. Org. Chem. 1999, 64, 21, 8034–8040Publication Date (Web):September 25, 1999Publication History Received12 May 1999Published online25 September 1999Published inissue 1 October 1999https://pubs.acs.org/doi/10.1021/jo990785vhttps://doi.org/10.1021/jo990785vbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views549Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Cross coupling reaction,Group 14 compounds,Organic reactions,Quinones,Substituents Get e-Alerts
Bimodal Imaging Probes for Combined PET and OI: Recent Developments and Future Directions for Hybrid Agent Development (2014)

Molecular imaging--and especially positron emission tomography (PET)--has gained increasing importance for diagnosis of various diseases and thus experiences an increasing dissemination. Therefore, there is also a growing demand for highly affine PET tracers specifically accumulating and visualizing target structures in the human body. Beyond the development of agents suitable for PET alone, recent tendencies aim at the synthesis of bimodal imaging probes applicable in PET as well as optical imaging (OI), as this combination of modalities can provide clinical advantages. PET, due to the high tissue penetration of the γ-radiation emitted by PET nuclides, allows a quantitative imaging able to identify and visualize tumors and metastases in the whole body. OI on the contrary visualizes photons exhibiting only a limited tissue penetration but enables the identification of tumor margins and infected lymph nodes during surgery without bearing a radiation burden for the surgeon. Thus, there is an emerging interest in bimodal agents for PET and OI in order to exploit the potential of both imaging techniques for the imaging and treatment of tumor diseases. This short review summarizes the available hybrid probes developed for dual PET and OI and discusses future directions for hybrid agent development.
<i>Plasmodium vivax</i> : Recent world expansion and genetic identity to <i>Plasmodium simium</i> (2005)

Plasmodium vivax causes the most geographically widespread human malaria, accounting annually for 70-80 million clinical cases throughout the tropical and subtropical regions of the world's continents. We have analyzed the DNA sequences of the Csp (circumsporozoite protein) gene in 24 geographically representative strains of P. vivax and 2 of P. simium, which parasitizes several species of New World monkeys. The Csp sequences are of two types, VK210 and VK247, which differ by three diagnostic amino acid replacements, one in each of the 5' and 3' terminal regions [5' nonrepeat (NR) and 3' NR] of the gene and in an insertion sequence that precedes the 3' NR region. The central region of the gene consists of approximately 38 repetitive "motifs," which are alternatively four and five amino acids long, which also are diagnostically different between the VK210 and VK247 types. There are very few synonymous substitutions within and between the two types of strains, which we hypothesize reflects that the worldwide spread of P. vivax is very recent. The two P. simium Csp sequences belong one to each of the two VK types and are genetically indistinguishable from the corresponding P. vivax strains, suggesting that at least two host transfers have occurred between humans and New World monkeys. We exclude as unlikely the possibility that the two types of sequences could have independently arisen in humans and platyrrhines by natural selection. There are reasons favoring each of the two possible directions of host transfer between humans and monkeys.
The first total synthesis of saurufuran B (2006)

First total synthesis of saurufuran B 1, a furanoditerpene, from (E, E)-famesol 2 and citraconic anhydride 3 through thirteen steps is described. Our work involves two key steps: (1) High regioselective alkylation of 2-(tert-butyldimethylsiloxy)-4-methylfuran 6 with allylic iodides 5 in the presence of silver trifluoroacetate and (2) Conversion of substituted gamma-lactone 7 into furan derivative 8(2).
Prediction Study on Anti-Slide Control of Railway Vehicle Based on RBF Neural Networks (2012)

While railway vehicle braking, Anti-slide control system will detect operating status of each wheel-sets e.g. speed difference and deceleration etc. Once the detected value on some wheel-set is over pre-defined threshold, brake effort on such wheel-set will be adjusted automatically to avoid blocking. Such method takes effect on guarantee safety operation of vehicle and avoid wheel-set flatness, however it cannot adapt itself to the rail adhesion variation. While wheel-sets slide, the operating status is chaotic time series with certain law, and can be predicted with the law and experiment data in certain time. The predicted values can be used as the input reference signals of vehicle anti-slide control system, to judge and control the slide status of wheel-sets. In this article, the RBF neural networks is taken to predict wheel-set slide status in multi-step with weight vector adjusted based on online self-adaptive algorithm, and the center & normalizing parameters of active function of the hidden unit of RBF neural networks’ hidden layer computed with K-means clustering algorithm. With multi-step prediction simulation, the predicted signal with appropriate precision can be used by anti-slide system to trace actively and adjust wheel-set slide tendency, so as to adapt to wheel-rail adhesion variation and reduce the risk of wheel-set blocking.
Optimizing Parameterized CAD Geometries Using Sensitivities Based on Adjoint Functions (2012)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.