gebhart/patrepeval huggingface dataset:
Multicomponent ocean bottom cable data in gas hydrate investigation offshore of Norway (2003)

A multicomponent seismic ocean bottom cable (OBC) line from the northern flank of the Storegga Slide offshore of Norway is the first OBC line ever acquired over a gas hydrate‐related bottom simulating reflector (BSR). The seismic data are of very good quality, and display strong P ‐ S converted wave reflections for the whole sediment column. All P ‐ S reflections follow the sediment layers and are therefore interpreted to be caused by increased shear modulus and density due to sediment compaction. No P ‐ S reflections are associated with the BSR along this line, indicating that the gas hydrate‐bearing sediments at the base of the hydrate stability zone are not stiff enough to increase the shear modulus of the sediments to produce P ‐ S converted wave reflections. Seismic interpretation and seismic stratigraphic modeling suggest that the BSR in this area is a contrast in compressional wave velocity only, mainly caused by small amounts of free gas confined to dipping sediment layers beneath the BSR. Gas hydrate saturation above the BSR, tentatively estimated to be about 1–1.5% of the sediment pore space, is most likely too low to distinguish between different models for microscale gas hydrate distribution.
Neurological diseases associated with autoantibodies targeting the voltage-gated potassium channel complex: immunobiology and clinical characteristics (2015)

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.
Aromatic Amino Acids Are Critical for Stability of the Bicoid Homeodomain (2001)

The Drosophila Bicoid (Bcd) protein plays a dual role as a transcription and translation factor dependent on the unique DNA and RNA binding properties of the homeodomain (HD). We have used circular dichroism and fluorescence spectroscopy to probe the structure and stability of the Bcd-HD, for which a high resolution structure is not yet available. The fluorescence from the single tryptophan residue in the HD (Trp-48) is strongly quenched in the native state but is dramatically enhanced ( approximately 20-fold) upon denaturation. Similar results were obtained with the Ultrabithorax HD (Ubx-HD), suggesting that the unusual tryptophan fluorescence may be a general phenomenon of HD proteins. We have used site-directed mutagenesis to explore the role of aromatic acids in the structure of the Bcd-HD and to evaluate the proposal that interactions between the strictly conserved Trp residue in HDs and nearby aromatic residues are responsible for the fluorescence quenching in the native state. We determined that both Trp-48 and Phe-8 in the N-terminal region of the HD are individually necessary for structural stability of the Bcd-HD, the latter most likely as a factor coordinating the orientation of the N-terminal helix I and the recognition helix for efficient binding to a DNA target.
Human Visual System Based Adaptive Watermarking in Frequency Domain (2005)

In this paper, we proposed watermarking algorithm based on wavelet transform. Discrete wavelet transform is involved to calculate additive energy strength. Considering imperceptibility, after computing contrast and texture sensitivity in gray-level image, we inserted watermark with variable weight due to the feature of coefficient block. Consequently, applying human visual system, the experimental results showed that the proposed algorithm satisfied the properties of robustness and imperceptibility that are the major conditions of watermarking.
Molecular modification of anticholinergics as probes for muscarinic receptors. 1. Amino esters of .alpha.-substituted phenylacetic acid and related analogs (1987)

Two series of compounds having the general structure of C6H5CRR'COOCH2CH2NEt2 were synthesized and examined for their antispasmodic activities. These compounds were selected as structural probes for exploring the nature of muscarinic cholinergic receptor binding sites that interact with atropine-like anticholinergics. These studies indicate a rather strict size limitation for the hydrophobic region of the receptor and suggest intramolecular hydrogen bonding as a possible means to explain the observed stereoselectivity.
Data mining neocortical high-frequency oscillations in epilepsy and controls (2011)

Transient high-frequency (100-500 Hz) oscillations of the local field potential have been studied extensively in human mesial temporal lobe. Previous studies report that both ripple (100-250 Hz) and fast ripple (250-500 Hz) oscillations are increased in the seizure-onset zone of patients with mesial temporal lobe epilepsy. Comparatively little is known, however, about their spatial distribution with respect to seizure-onset zone in neocortical epilepsy, or their prevalence in normal brain. We present a quantitative analysis of high-frequency oscillations and their rates of occurrence in a group of nine patients with neocortical epilepsy and two control patients with no history of seizures. Oscillations were automatically detected and classified using an unsupervised approach in a data set of unprecedented volume in epilepsy research, over 12 terabytes of continuous long-term micro- and macro-electrode intracranial recordings, without human preprocessing, enabling selection-bias-free estimates of oscillation rates. There are three main results: (i) a cluster of ripple frequency oscillations with median spectral centroid = 137 Hz is increased in the seizure-onset zone more frequently than a cluster of fast ripple frequency oscillations (median spectral centroid = 305 Hz); (ii) we found no difference in the rates of high frequency oscillations in control neocortex and the non-seizure-onset zone neocortex of patients with epilepsy, despite the possibility of different underlying mechanisms of generation; and (iii) while previous studies have demonstrated that oscillations recorded by parenchyma-penetrating micro-electrodes have higher peak 100-500 Hz frequencies than penetrating macro-electrodes, this was not found for the epipial electrodes used here to record from the neocortical surface. We conclude that the relative rate of ripple frequency oscillations is a potential biomarker for epileptic neocortex, but that larger prospective studies correlating high-frequency oscillations rates with seizure-onset zone, resected tissue and surgical outcome are required to determine the true predictive value.
Photochemical versus Thermal Synthesis of Cobalt Oxyhydroxide Nanocrystals (2012)

Photochemical methods facilitate the generation, isolation, and study of metastable nanomaterials having unusual size, composition, and morphology. These harder-to-isolate and highly reactive phases, inaccessible using conventional high-temperature pyrolysis, are likely to possess enhanced and unprecedented chemical, electromagnetic, and catalytic properties. We report a fast, low-temperature and scalable photochemical route to synthesize very small (∼3 nm) monodisperse cobalt oxyhydroxide (Co(O)OH) nanocrystals. This method uses readily and commercially available pentaamminechlorocobalt(III) chloride, [Co(NH3)5Cl]Cl2, under acidic or neutral pH and proceeds under either near-UV (350 nm) or Vis (575 nm) illumination. Control experiments showed that the reaction proceeds at competent rates only in the presence of light, does not involve a free radical mechanism, is insensitive to O2, and proceeds in two steps: (1) Aquation of [Co(NH3)5Cl]2+ to yield [Co(NH3)5(H2O)]3+, followed by (2) slow photoinduced release of NH3 from the aqua complex. This reaction is slow enough for Co(O)OH to form but fast enough so that nanocrystals are small (ca. 3 nm). The alternative dark thermal reaction proceeds much more slowly and produces much larger (∼250 nm) polydisperse Co(O)OH aggregates. UV–Vis absorption measurements and ab initio calculations yield a Co(O)OH band gap of 1.7 eV. Fast thermal annealing of Co(O)OH nanocrystals leads to Co3O4 nanocrystals with overall retention of nanoparticle size and morphology. Thermogravimetric analysis shows that oxyhydroxide to mixed-oxide phase transition occurs at significantly lower temperatures (up to ΔT = 64 °C) for small nanocrystals compared with the bulk.
Energy conservation policies for web servers (2003)

Energy management for servers is now necessary for technical, financial, and environmental reasons. This paper describes three policies designed to reduce energy consumption in Web servers. The policies employ two power management mechanisms: dynamic voltage scaling (DVS), an existing mechanism, and request batching, a new mechanism introduced in this paper. The first policy uses DVS in isolation, except that we extend recently introduced task-based DVS policies for use in server environments with many concurrent tasks. The second policy uses request batching to conserve energy during periods of low workload intensity. The third policy uses both DVS and request batching mechanisms to reduce processor energy usage over a wide range of workload intensities. All the policies trade off system responsiveness to save energy. However, the policies employ the mechanisms in a feedback-driven control framework in order to conserve energy while maintaining a given quality of service level, as defined by a percentile-level response time.

We evaluate the policies using Salsa, a web server simulator that has been extensively validated for both energy and response time against measurements from a commodity web server. Three daylong static web workloads from real web server systems are used to quantify the energy savings: the Nagano Olympics98 web server, a financial services company web site, and a disk intensive web workload. Our results show that when required to maintain a 90th-percentile response time of 50ms, the DVS and request batching policies save from 8.7% to 38% and from 3.1% to 27% respectively of the CPU energy used by the base system. The two polices provide these savings for complementary workload intensities. The combined policy is effective for all three workloads across a broad range of intensities, saving from 17% to 42% of the CPU energy.
Microprocessor-controlled ultrasonic plethysmograph (1981)

Safe, nonintrusive microprocessor system times ultrasonic pulses to measure limb cross-sectional area. Simple instrument requires no calibration and does not confine leg movement, making tests relating limb volume to activity level possible. Program considers more realistic geometries of human limb than circular cross-sections and monitors changes in area with great accuracy. Errors due to body temperature changes and timing roundoff are insignificant.
Removal of clay by stingless bees: load size and moisture selection (2014)

Some organisms disperse energy, associated with the transportation of resource, which is not necessarily food. Stingless bees of Central Amazonia (Melipona flavolineata and M. lateralis) collect clay in banks along streams for nest building. The moisture of the clay varies along the bank, and bees collect clay from specific location, indicating that there is some sort of preference regarding their selection. This study aims at identifying: if larger bees carry more clay; if there is a preference for moisture of substrates; and if bees are less efficient accumulating and transporting clay when it is wet. In order to do so, I measured the size of the bees and of the pellets of clay found in the corbicula. I set up a field experiment to test substrate preferences. The amount of clay transported, increased exponentially in accordance to the size of the bee, and the preferred substrate was the driest clay. The amount and the efficiency of removal of clay were not affected by the moisture of the substrate. Despite the wet clay being denser, it does not reduce the efficiency of exploitation of the resource, but suggests that bees spend more energy to carry the same quantity of wet clay, which may be the underlying mechanism explaining their preference for removing drier clay.
A Riccati Equation Approach to Approximate u-Norm Computation (1992)

The problem of approximating an upper bound for the p-norm with constant D-scaling (SSUB) for LTI systems is considered. A Riccati equation approach, referred as D-P iteration, is developed to compute the SSUB and a complete characterization of this approach is derived. This includes the convexity of the approach and the derivations of verifiable conditions when the SSUB is achieved, when the SSUB is equal to the FDUB and when the SSUB is equal to the -norm.
Microchip electrophoresis of <i>N</i>‐glycans on serpentine separation channels with asymmetrically tapered turns (2011)

We designed and fabricated microfluidic devices with serpentine separation channels and asymmetrically tapered turns, thus allowing high efficiency separations and minimizing band broadening associated with the "racetrack" effect. We evaluated the performance of these devices by measuring the variation in separation efficiency with separation length, electric field strength, taper ratio of the turns, and number of turns. N-Glycans derived from ribonuclease B and labeled with 8-aminopyrene-1,3,6-trisulfonic acid were electrophoretically separated on serpentine channels with separation lengths of 11, 18, 22, and 36 cm at electric field strengths from 750 to 1750 V/cm. Separations on the 36-cm channel produced plate numbers up to 940,000 with an analysis time under 3.1 min, whereas separations on the 22-cm channel had a shorter analysis time (less than 1.25 min), still with respectable efficiencies (up to 600,000 plates). Turn-induced dispersion was minimized with taper ratios 2 and 3, whereas having two or four 180° turns along with the separation length did not impact the overall efficiency. The developed device was used to analyze native and desialylated N-glycans derived from the blood serum of an ovarian cancer patient and a disease-free individual. Separation efficiencies similar to that achieved with the model glycans from ribonuclease B were attained for these biological samples.
Sub-picoliter detection with the sheath flow cuvette (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSub-picoliter detection with the sheath flow cuvetteFahimeh. Zarrin and Norman J. DovichiCite this: Anal. Chem. 1985, 57, 13, 2690–2692Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ac00290a057https://doi.org/10.1021/ac00290a057research-articleACS PublicationsRequest reuse permissionsArticle Views443Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Micro Level Evaluation of Vitamin -A Prophylaxis Programme (1994)

Research Question : what is the extent of Vit A Coverage of Pre-school children in a PHC? 2. What is the impact of the programme on the prevalence of vit. A deficiency? Objective: 1. To conduct a micro level evaluation of Vit. A prophylaxis programme within a selected area of a PHC in term of : (a) programme performances (b) impact on the prevalence of Vit A deficiency. Study Design: Cross sectional Setting: Selected subcentres of PHC Dankaur . Bulandshahr District, U.P. Participants: Pre â€" school children. Sample size : 986 pre school children from 714 households Study Variables: age, doses of Vit- A received. Outcome variables: Extent of coverage Vit-A deficiency signs. Statistical Analysis: Proportions , Regression coefficient, Analysis of Variance. Results: The reported achievement of Vit A prophyxis was 100%. How ever, the actual coverage was 9.8% and none of these had received appropriate doses for their ages. The prevalence of Bitot spot was 5.1% with a statistically significant increase with increasing Age. Medical and para medical personnel were inadequately informed about the Vit A prophylaxis programme and the supply of Vit A had been irregular. Recommendations: Adequate and correct information should be given to all health workers regarding age of children beneficiaries for Vit A, number and interval between doses. Realistic targets should be set which should take into account the actual number of beneficiaries in the community. Vit A supply should be regular and monitoring of the programme should be done at frequent intervals.
Hyperglycemia affects proximal gastric motor and sensory function during small intestinal triglyceride infusion (1996)

Hyperglycemia slows gastric emptying in normal individuals and patients with diabetes mellitus and may affect both somatic and visceral sensation. The effects of hyperglycemia on proximal gastric motility and sensation during intraduodenal infusion of a triglyceride emulsion were evaluated using a barostat in six normal subjects during euglycemia and hyperglycemia (approximately 15 mmol/l). Isobaric distension induced greater bag volumes during hyperglycemia compared with euglycemia at 3 (452 +/- 26 vs. 343 +/- 12 ml, P < 0.05) and 4 mmHg (600 +/- 55 vs. 497 +/- 50 ml, P < 0.05) above basal pressure. During isovolumetric distension, intrabag pressure was less during hyperglycemia at 500 (2.5 +/- 0.3 vs. 3.5 +/- 0.5 mmHg above basal pressure, P < 0.05) and 600 ml (3.0 +/- 0.4 vs. 4.5 +/- 0.5 mmHg above basal pressure, P < 0.05). Perception of nausea (P < 0.05) and fullness (P < 0.05) was increased during hyperglycemia compared with euglycemia. We conclude that hyperglycemia 1) reduces proximal gastric tone during intraduodenal triglyceride infusion, an effect that may contribute to delayed gastric emptying, and 2) increases the intensity of nausea and fullness during intraduodenal triglyceride infusion and proximal gastric distension, indicative of an effect on visceral sensation.
An Availability Model for Distributed Transaction Systems (1985)

A method is proposed for quantitatively evaluating the availability of a distributed transaction system (DTS). The DTS dynamics can be modeled as a Markov process. The problem of formulating the set of linear homogeneous equations is considered, obtaining the related coefficient matrix, that is, the transition rate matrices of the DTS elements. Such operations can be performed according to the rules of Kronecker algebra. The transition rate matrices are used to calculate the probabilities of the different possible states of the DTS. The availability with respect to a transaction T is computed through its representation by means of a structure graph and a structure vector related to the probabilistic state of the DTS element relevant to the transaction T itself.
Populations in the metastable and the resonance levels of argon and stepwise ionization effects in a low-pressure argon positive column (1985)

The contribution of the ionization from the two metastable and the two resonance levels of argon to the total ionization rate in a low-pressure argon positive column is investigated theoretically and experimentally. A simple yet self-consistent discharge model is developed by coupling the balance between the electron total production and loss rates to the steady-state rate balance equations for the excited states. The predictions of this model, i.e., the maintenance field for the positive column and the populations in the individual excited states as a function of the gas pressure and the discharge current are compared with the experiment (0.05&lt;p&lt;1 Torr; 0.2&lt;I&lt;20 mA; φ=2.6-cm-i.d. discharge tube). It is shown that stepwise ionization becomes predominant for pressures larger than a few tenths of a Torr even for the lowest currents of this experiment. The predicted values of the maintenance field are considerably lower than those that would be required to sustain the discharge by ground-state ionization and compare favorably with the measurements. The calculated populations in the metastable states also compare reasonably well with the experiment. The discrepancies are, however, quite large in the case of the resonance levels owing, presumably, to the lack of accuracy of the theoretical escape factors for the resonance radiation.
Synthesis, Thermal Decomposition and Sensitivity Study of CsDNBF (2007)

Abstract CsDNBF (cesium 7‐hydroxy‐4,6‐dinitro‐5,7‐dihydrobenzofuroxanide) was synthesized from the sodium salt of DNBF and cesium nitrate. The thermal decomposition process has been investigated and the results show that the solid residues at 240 °C are RCOOCs, CsNCO, RNO 2 and CsNO 3 . The sensitivity results demonstrate that CsDNBF has better properties than KDNBF, which has been widely used.
Control of Circadian Rhythms and Photoperiodic Flowering by the <i>Arabidopsis GIGANTEA</i> Gene (1999)

Photoperiodic responses in plants include flowering that is day-length-dependent. Mutations in the Arabidopsis thaliana GIGANTEA (GI) gene cause photoperiod-insensitive flowering and alteration of circadian rhythms. The GI gene encodes a protein containing six putative transmembrane domains. Circadian expression patterns of the GI gene and the clock-associated genes, LHY and CCA1, are altered in gi mutants, showing that GI is required for maintaining circadian amplitude and appropriate period length of these genes. The gi-1 mutation also affects light signaling to the clock, which suggests that GI participates in a feedback loop of the plant circadian system.
Role of Carbonyl Modifications on Aging-Associated Protein Aggregation (2016)

Protein aggregation is a common biological phenomenon, observed in different physiological and pathological conditions. Decreased protein solubility and a tendency to aggregate is also observed during physiological aging but the causes are currently unknown. Herein we performed a biophysical separation of aging-related high molecular weight aggregates, isolated from the bone marrow and splenic cells of aging mice and followed by biochemical and mass spectrometric analysis. The analysis indicated that compared to younger mice an increase in protein post-translational carbonylation was observed. The causative role of these modifications in inducing protein misfolding and aggregation was determined by inducing carbonyl stress in young mice, which recapitulated the increased protein aggregation observed in old mice. Altogether our analysis indicates that oxidative stress-related post-translational modifications accumulate in the aging proteome and are responsible for increased protein aggregation and altered cell proteostasis.