gebhart/patrepeval huggingface dataset:
Effect of clonidine, quipazine, and LY 53857 on the prolactin-suppressant action of bromocriptine in rats. (1986)

The alpha 2-adrenergic agonist clonidine hydrochloride, the serotonin agonist quipazine maleate, and the serotonin (5-HT2) antagonist LY 53857 were tested alone and in various combinations for their capabilities to increase mean serum prolactin (MSP) concentrations in rats given the synthetic ergot alkaloid CB-154 (2-bromo-alpha-ergocriptine), a known prolactin suppressor. The LY 53857 and the combination of clonidine, quipazine, and LY 53857 significantly decreased MSP concentrations. Quipazine given alone (10 mg/kg of body weight) was best able to increase MSP concentration and has potential to antagonize prolactin-depressant effects of ergot alkaloids.
Extensions of a semilattice by an inverse semigroup (1973)

The structure of inverse semigroup extensions of one inverse semigroup R by any other is analyzed in the case where R is a semilattice. Both a representation and method of construction are given. A brief preliminary examination is made of a certain class of congruences, on inverse semigroups, which are intimately related to such extensions.
Theoretical study of the electronic and magnetic structures of the Heusler alloys<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mi mathvariant="normal">Co</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">Cr</mml:mi><mml:mrow><mml:mn>1</mml:mn><mml:mo>−</mml:mo><mml:mi>x</mml:mi></mml:mrow></mml:msub><mml:msub><mml:mi mathvariant="normal">Fe</mml:mi><mml:mi>x</mml:mi></mml:msub><mml:mi mathvariant="normal">Al</mml:mi></mml:mrow></mml:math> (2005)

The electronic structure, x-ray absorption (XAS), x-ray magnetic circular dichroism (XMCD), and magneto-optical spectra of the doped Heusler alloys ${\mathrm{Co}}_{2}{\mathrm{Cr}}_{1\ensuremath{-}x}{\mathrm{Fe}}_{x}\mathrm{Al}$ ($x=0$, 0.125, 0.25, 0.375, 0.5, 0.625, 0.75, and 1) were investigated theoretically from first principles, using the fully relativistic Dirac linear-muffin-tin-orbital band structure method. It was shown that the concentration and arrangement of Fe atoms in the lattice play the leading role in the formation of the magnetic properties of the compounds, determining to a considerable extent the magnetic states of Co and Cr atoms. The spin polarization of electron states at the Fermi energy is quite high (about 95%) for the compositions between $x=0$ and $x=0.4$, owing to the presence of high peaks of majority-spin Cr and Co $d$ density of states at the Fermi energy. Further increasing of Fe content leads to the abrupt decreasing of the spin polarization of carriers. The band structure calculations in the LSDA approximation reproduce quite well the shape of the XAS and XMCD spectra at the Co, Fe, and Cr ${L}_{2,3}$ edges. The energy dependence of the matrix elements affects strongly the values of both the spin and the orbital magnetic moments derived from the calculated XAS and XMCD spectra using the sum rules. Our calculations show that the magneto-optical measurements are sensitive to changes in the structure of compounds (doping, disorder, etc.) accompanied by changes of the magnetic states of atoms.
Polarization imaging sensor for cell and tissue imaging and diagnostics (2006)

Based on high performance fast tunable phase retarder and novel algorithm, an innovative polarization imaging solution is proposed. It allows very fast recording the polarization images at the speed limit of a CCD. It contains no moving parts and can accommodate to most of the existing CCD cameras. The unique measurement procedure allows efficient, accurate sensing of the polarization imaging. A computer-aided diagnosis software has been developed for the proposed polarization imaging system.
Augmentation of meniscal repairs with cyanoacrylate glue (1995)

Cyanoacrylate glues are biodegradable, bacteriostatic, hemostatic adhesives which have been used experimentally in surgical procedures on many tissues. This study evaluates the efficacy of cyanoacrylate glues used for in vitro bovine meniscus repair. Our hypothesis was that a local adhesive might improve fixation of meniscus tears reapproximated with suture, or obviate the need for suture. Three high-viscosity flexible cyanoacrylate glues were tested and their tensile strengths compared to those of suture alone and suture augmented with glue. The flexible formulation enables the glue to deform with the meniscus during movement of the knee joint. Bovine meniscus tissue was used as the model to compare the tensile strength at the meniscus repair site using the 300 cps glue in combination with 3-0 prolene suture, 300 cps cyanoacrylate glue alone, and suture alone. Twenty specimens were included in each repair group, and the peak load to failure was normalized for surface area and subjected to analysis of variance. Results of the analysis showed that the peak load to failure of the combination of cyanoacrylate glue plus suture was significantly higher than that of glue alone (P < .0001), but not significantly higher than that of suture alone (P = .18). However, in tissues repaired with suture, tissue separation at the tear site was noted almost immediately after distraction started, as a result of the elasticity of the suture. The combination of cyanoacrylate glue plus suture provided the maximum tensile strength before tissue separation. Because tissue separation may interfere with the meniscal healing process, glue used in combination with suture appears to offer some advantage mechanically.(ABSTRACT TRUNCATED AT 250 WORDS)
Vinyl Aromatic Compounds. I. The Vapor Phase Dehydration of Arylmethylcarbinols (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVinyl Aromatic Compounds. I. The Vapor Phase Dehydration of ArylmethylcarbinolsDavid T. Mowry, Mary Renoll, and W. Frederick HuberCite this: J. Am. Chem. Soc. 1946, 68, 6, 1105–1109Publication Date (Print):June 1, 1946Publication History Published online1 May 2002Published inissue 1 June 1946https://pubs.acs.org/doi/10.1021/ja01210a059https://doi.org/10.1021/ja01210a059research-articleACS PublicationsRequest reuse permissionsArticle Views530Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Continuous wave operation of InAs/InAs<i>x</i>Sb1−<i>x</i> midinfrared lasers (1995)

Effective band gaps of type-II superlattices (SLs) can cover a wide infrared wavelength range, even beyond the narrowest band gap of any natural antimonide semiconductor alloys. This letter reports the first InAs/InAsxSb1−x type-II SL lasers with cw, optically pumped operation up to 95 K. The stimulated emission results from spatially indirect transitions of relatively extended electron states in the InAs/InAsxSb1−x SL conduction band to the hole states that are localized in the InAsx Sb1−x layers. The lasing wavelength is around 3.3–3.4 μm. Equivalent threshold current densities are estimated to be 3.3 and 56 A/cm2 at sample temperatures of 5 and 95 K, respectively. The characteristic temperature (T0) is approximately 32 K. These results demonstrate that the InAs/InAsxSb1−x type-II SL clad by AlAs0.16Sb0.84 ordered-alloy layers is a promising material system for midwave infrared semiconductor lasers.
Topical cyclosporin induces hair growth in human split skin grafted onto nude mice. (1991)

Previously we observed that systemic CyA induces hair growth in an experimental model of human scalp skin graft transplanted onto nude mice. In the present study we investigated the role of topical CyA in the murine transplantation model, using human split-thickness skin grafts (HSTSG). Ten mice grafted with 1-mm-thick skin and another 10 mice grafted with 0.4-mm-thick skin were treated topically with CyA in olive oil. Ten other mice, treated with olive oil only, served as a control group. At the end of the study we observed hair growth only on the grafted skin of the CyA-treated group. Four out of 10 grafts showed hair growth in each of the groups. Quantitative analysis of transverse sections of cylindrical punch biopsy specimens of HSTSG before transplantation revealed anagen follicles, including small ones and telogen/catagen follicles, whereas specimens after skin transplantation showed terminal follicles mostly in the anagen phase. The present study provides further support to previous observations regarding the beneficial effect of CyA on hair growth.
Localization of mobile equipment in radio environments with no line-of-sight path (2013)

In recent years, radio positioning has received increasing attention and found many applications in various areas. However, the existence of non-line-of-sight (NLOS) paths introduces considerable positioning errors. In this paper, we propose a two-step approach in order to deal with pure NLOS scenarios based on a simple assumption regarding the propagation environment. A nonlinear least squares (NLS) method is proposed for the initial estimation, followed by a Kalman filter-based method to track subsequent movements. Compared with previous studies, fewer measurements are required to be made. Simulation results are provided to show the performance of both methods.
Angina Bolhosa Hemorrágica – Caso Clínico (1995)

Os autores relatam um caso de angina bolhosa hemorragica, um disturbio no qual aparecem bolhas de sangue na cavidade oral, que deve se incluido no diagnostico diferencial de outras afeccoes.
Fine-tune BERT with Sparse Self-Attention Mechanism (2019)

Baiyun Cui, Yingming Li, Ming Chen, Zhongfei Zhang. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP). 2019.
Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception. (1992)

Mifepristone was effective in reducing expected pregnancy rates and the Yuzpe method also had a clinical effect. Danazol had little or no effect. A further multicentre trial is needed.
A study of profiled handoff for Diffserv‐based mobile nodes (2002)

Abstract There is a growing interest in providing Internet services to the mobile nodes. When mobile nodes travel from one router's service area to another, the time‐sensitive applications may see degradation in service. We investigate into the effects of handoff on service quality of mobile nodes. Several experiments are conducted using various packet metering and marking schemes with or without transferring profiles to the new router. Results indicate the relative instability period following handoff, loss of packets and delay encountered by packets in profiled or un‐profiled handoffs, leading to determining suitable mix of metering and marking schemes with or without context transfer. Copyright © 2002 John Wiley & Sons, Ltd.
Expression of Purinergic Receptor Channels and Their Role in Calcium Signaling and Hormone Release in Pituitary Gonadotrophs (1996)

The role of ATP as a positive feedback element in Ca2+ signaling and secretion was examined in female rat pituitary gonadotrophs. ATP and ADP, but not AMP or adenosine, induced a dose- and extracellular Ca2+-dependent rise in [Ca2+]i in identified gonadotrophs in a Mg2+- and suramin-sensitive manner. ATP, adenosine-5'-O-(3-thiotriphosphate), adenosine-5'-O-(1-thiotriphosphate), 2-methylthio-ATP, and 3'-O-(4-benzoyl)benzoyl-ATP were roughly equipotent in rising [Ca2+]i in gonadotrophs, while ADP was effective only at submillimolar concentration range, and none of these compounds permeabilized the cells. On the other hand, alpha,beta-methylene-ATP, beta,gamma-methylene-ATP, and UTP were unable to induce any rise in [Ca2+]i. This pharmacological profile is consistent with expression of P2X2 and/or P2X5 purinergic receptor channels. Patch-clamp experiments showed that ATP induced an inward depolarizing current in gonadotrophs clamped at -90 mV, associated with an increase in [Ca2+]i. The ATP-induced [Ca2+]i response was partially inhibited by nifedipine, a blocker of voltage-sensitive Ca2+ channels (VSCC), but was not affected by tetrodotoxin, a blocker of voltage-sensitive Na+ channels. Thus, the P2-depolarizing current itself drives Ca2+ into the cell, but also activates Ca2+ entry through VSCC. In accord with this, low [ATP] induced plasma membrane-dependent [Ca2+]i oscillations in quiescent cells, and increased the frequency of spiking in spontaneously active cells. ATP-induced Ca2+ influx also affected agonist-induced and InsP3-dependent [Ca2+]i oscillations by increasing the frequency, base line, and duration of Ca2+ spiking. In addition, ATP stimulated gonadotropin secretion and enhanced agonist-induced gonadotropin release. ATP was found to be secreted by pituitary cells during agonist stimulation and was promptly degraded by ectonucleotidase to adenosine. These observations indicate that ATP represents a paracrine/autocrine factor in the regulation of Ca2+ signaling and secretion in gonadotrophs, and that these actions are mediated by P2 receptor channels.
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment (2004)

Nitric oxide (NO) production by the vascular endothelium maintains an essential antiinflammatory, cytoprotective influence on the blood vessel wall. A key component of this activity is attributed to prevention of leukocyte-endothelial cell interactions, yet the underlying mechanisms remain unclear. The NO receptor, soluble guanylate cyclase (sGC), is expressed in endothelial cells but fulfils an unknown function. Therefore, we used intravital microscopy in mesenteric postcapillary venules from WT and endothelial nitric oxide synthase (eNOS) knockout (eNOS(-/-)) mice, and an sGC activator (BAY 41-2272), to investigate a potential role for sGC in the regulation of adhesion molecule expression and leukocyte recruitment. Leukocyte rolling and adhesion was 6-fold greater in eNOS(-/-) than WT animals. BAY 41-2272 and the NO-donor, diethylamine-NONOate, reduced leukocyte rolling and adhesion in eNOS(-/-) mice to levels observed in WT animals. These effects were blocked by the sGC inhibitor ODQ [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one], which itself caused a 6-fold increase in leukocyte rolling and adhesion in WT mice. Increased leukocyte rolling and adhesion in IL-1beta-treated mice was also inhibited by BAY 41-2272. Fluorescence-activated cell sorting analysis in vitro and a specific P-selectin neutralizing antibody in vivo revealed that selective down-regulation of P-selectin expression accounted for the antiadhesive effects of sGC activation. These data demonstrate that sGC plays a key antiinflammatory role by inhibiting P-selectin expression and leukocyte recruitment.
ATMOSPHERICS/WEATHER WORKS: A MULTI-CHANNEL STORM SONIFICATION PROJECT (2004)

Atmospherics/Weather Works is an interdisciplinary project in the sonification of storms and other meteorological events generated directly from data produced by a highly detailed and physically accurate model of weather systems used for research and forecasting. This paper discusses the background, conception, and execution of a series of sonifications of a historical hurricane and winter snowstorm that resulted in several performances, stereo recordings, a public multi-channel spatialized sound installation, and an online interactive sound listening environment. 1.
A 256K CMOS SRAM with variable impedance data-line loads (1985)

A 256K (32K/spl times/8) CMOS SRAM utilizing variable impedance loads and a pulsed word-line (PWL) technique is described. In the WRITE cycle, the variable impedance loads of the data lines enter a high impedance state and reduce the operating power. During the READ cycle, the PWL technique is used to achieve high-speed operation and low power dissipation. The internal clocks generated by the address transition detectors activate word-line and sense amplifiers for READ operation and disable them after the data are sent to D/SUB out/ buffers. This PWL technique eliminates the precharge time of 20 ns, which corresponds to 30% of the access time. The RAM offers 45-ns address access time and 40-mW operating power in the WRITE cycle of 1 MHz.
Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy (2011)

ATP7A is a P-type ATPase that regulates cellular copper homeostasis by activity at the trans-Golgi network (TGN) and plasma membrane (PM), with the location normally governed by intracellular copper concentration. Defects in ATP7A lead to Menkes disease or its milder variant, occipital horn syndrome or to a newly discovered condition, ATP7A-related distal motor neuropathy (DMN), for which the precise pathophysiology has been obscure. We investigated two ATP7A motor neuropathy mutations (T994I, P1386S) previously associated with abnormal intracellular trafficking. In the patients' fibroblasts, total internal reflection fluorescence microscopy indicated a shift in steady-state equilibrium of ATP7A(T994I) and ATP7A(P1386S), with exaggerated PM localization. Transfection of Hek293T cells and NSC-34 motor neurons with the mutant alleles tagged with the Venus fluorescent protein also revealed excess PM localization. Endocytic retrieval of the mutant alleles from the PM to the TGN was impaired. Immunoprecipitation assays revealed an abnormal interaction between ATP7A(T994I) and p97/VCP, an ubiquitin-selective chaperone which is mutated in two autosomal dominant forms of motor neuron disease: amyotrophic lateral sclerosis and inclusion body myopathy with early-onset Paget disease and fronto-temporal dementia. Small-interfering RNA (SiRNA) knockdown of p97/VCP corrected ATP7A(T994I) mislocalization. Flow cytometry documented that non-permeabilized ATP7A(P1386S) fibroblasts bound a carboxyl-terminal ATP7A antibody, consistent with relocation of the ATP7A di-leucine endocytic retrieval signal to the extracellular surface and partially destabilized insertion of the eighth transmembrane helix. Our findings illuminate the mechanisms underlying ATP7A-related DMN and establish a link between p97/VCP and genetically distinct forms of motor neuron degeneration.
Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean (2010)

A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to inhibit the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.
A New Look at the Easy-Hard-Easy Pattern of Combinatorial Search Difficulty (1997)

The easy-hard-easy pattern in the difficulty of combinatorial search problems as constraints are added has been explained as due to a competition between the decrease in number of solutions and increased pruning. We test the generality of this explanation by examining one of its predictions: if the number of solutions is held fixed by the choice of problems, then increased pruning should lead to a monotonic decrease in search cost. Instead, we find the easy-hard-easy pattern in median search cost even when the number of solutions is held constant, for some search methods. This generalizes previous observations of this pattern and shows that the existing theory does not explain the full range of the peak in search cost. In these cases the pattern appears to be due to changes in the size of the minimal unsolvable subproblems, rather than changing numbers of solutions.
Dynamic Partial FPGA Reconfiguration in a Prototype Microprocessor System (2007)

Modern FPGAs' parallel computing capability and their ability to be reconfigured make them an ideal platform to build accelerators for supercomputing systems. As a multi-core processor, the recently announced Cell Broadband EngineTM1 offers tremendous computing power. In this paper, we introduce a prototype system that combines these two types of computing devices together in a reconfigurable blade and we describe its architecture, memory system and abundant interfaces. On the reconfigurable blade it is desirable that the FPGA devices can be partially reconfigured at run-time. This paper presents the dynamic partial reconfiguration (DPR) technique and its design flow for the reconfigurable blade. We report our experimental results of the blade doing partial reconfiguration. DPR allows the reconfigurable blade to be a powerful, run-time changeable computing engine. A sample application is presented that was both simulated for the Cell processor and dynamically loaded to run on the FPGA.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs (2015)

The emergence of drug resistance is a major limitation of current antimalarials. The discovery of new druggable targets and pathways including those that are critical for multiple life cycle stages of the malaria parasite is a major goal for developing next-generation antimalarial drugs. Using an integrated chemogenomics approach that combined drug resistance selection, whole-genome sequencing, and an orthogonal yeast model, we demonstrate that the cytoplasmic prolyl-tRNA (transfer RNA) synthetase (PfcPRS) of the malaria parasite Plasmodium falciparum is a biochemical and functional target of febrifugine and its synthetic derivative halofuginone. Febrifugine is the active principle of a traditional Chinese herbal remedy for malaria. We show that treatment with febrifugine derivatives activated the amino acid starvation response in both P. falciparum and a transgenic yeast strain expressing PfcPRS. We further demonstrate in the Plasmodium berghei mouse model of malaria that halofuginol, a new halofuginone analog that we developed, is active against both liver and asexual blood stages of the malaria parasite. Halofuginol, unlike halofuginone and febrifugine, is well tolerated at efficacious doses and represents a promising lead for the development of dual-stage next-generation antimalarials.