gebhart/patrepeval huggingface dataset:
Content of α‐tocopherol in blood serum of human<i>papillomavirus‐infected</i>women with cervical dysplasias (1997)

The studies were carried out in a group of 228 female patients with normal cytological smear and 324 patients with cervical intraepithelial neoplasia. The applied method of identification, i.e., the human Papillomavirus (HPV) digene hybrid capture system, made it possible to select a control group consisting of 168 HPV-negative patients with normal Pap smear, as well as a group of 228 HPV-positive patients with cervical intraepithelial neoplasia. The high-performance liquid chromatography method was employed to evaluate the level of alpha-tocopherol in the blood serum of the patients who were examined. A statistically significantly lower level of alpha-tocopherol was observed in the blood serum of HPV-positive patients with cervical intraepithelial neoplasia. The risk of dysplasia was four times higher for an alpha-tocopherol level < 7.95 mumol/l.
The virulence factors of Bordetella pertussis: a matter of control (2001)

Bordetella pertussis is the causative agent of whooping cough, a contagious childhood respiratory disease. Increasing public concern over the safety of whole-cell vaccines led to decreased immunisation rates and a subsequent increase in the incidence of the disease. Research into the development of safer, more efficacious, less reactogenic vaccine preparations was concentrated on the production and purification of detoxified B. pertussis virulence factors. These virulence factors include adhesins such as filamentous haemagglutinin, fimbriae and pertactin, which allow B. pertussis to bind to ciliated epithelial cells in the upper respiratory tract. Once attachment is initiated, toxins produced by the bacterium enable colonisation to proceed by interfering with host clearance mechanisms. B. pertussis co-ordinately regulates the expression of virulence factors via the Bordetella virulence gene (bvg) locus, which encodes a response regulator responsible for signal-mediated activation and repression. This strict regulation mechanism allows the bacterium to express different gene subsets in different environmental niches within the host, according to the stage of disease progression.
(+)-Germacrene A Biosynthesis (1998)

The leaves and especially the roots of chicory (Cichorium intybus L. ) contain high concentrations of bitter sesquiterpene lactones such as the guianolides lactupicrin, lactucin, and 8-deoxylactucin. Eudesmanolides and germacranolides are present in smaller amounts. Their postulated biosynthesis through the mevalonate-farnesyl diphosphate-germacradiene pathway has now been confirmed by the isolation of a (+)-germacrene A synthase from chicory roots. This sesquiterpene cyclase was purified 200-fold using a combination of anion-exchange and dye-ligand chromatography. It has a Km value of 6. 6 &mgr;M, an estimated molecular mass of 54 kD, and a (broad) pH optimum around 6.7. Germacrene A, the enzymatic product, proved to be much more stable than reported in literature. Its heat-induced Cope rearrangement into (-)-beta-elemene was utilized to determine its absolute configuration on an enantioselective gas chromatography column. To our knowledge, until now in sesquiterpene biosynthesis, germacrene A has only been reported as an (postulated) enzyme-bound intermediate, which, instead of being released, is subjected to additional cyclization(s) by the same enzyme that generated it from farnesyl diphosphate. However, in chicory germacrene A is released from the sesquiterpene cyclase. Apparently, subsequent oxidations and/or glucosylation of the germacrane skeleton, together with a germacrene cyclase, determine whether guaiane- or eudesmane-type sesquiterpene lactones are produced.
Using LSTMs for Predicting Patient's Expenditure on Medications (2017)

Managing expenditure on medications is a serious challenge faced by patients, in particular for those who cannot afford costly health care. Predicting patient's spending on medications becomes crucial for efficient planning, budgeting, and decision-making. However, little attention has been given to predicting patient expenditure using deep time-series forecasting methods. The primary objective of this paper is the time-series forecasting of patient expenditures on medications using both traditional and deep time-series forecasting methods. A traditional Auto Regressive Integrated Moving Average (ARIMA) model; and, two deep models, a standard Long Short-Term Memory (LSTM) model and a stacked LSTM model were calibrated to predict the monthly expenditure on medication for 50,000+ patients in the US between 2011 and 2015. The first 48 months were used for training the models and the remaining 12 months were used for testing the models. Results revealed that the stacked LSTM model performed better than both the standard LSTM and ARIMA models during test conditions. Overall, both the deep time-series models performed better than the traditional time-series ARIMA model. We highlight the implications of our results for forecasting time-series data involving patient journeys.
Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate. (1993)

Deoxyuridine triphosphate (dUTP) misincorporation and uracil misrepair have long been implicated in fluoropyrimidine-induced DNA damage; however, the enzymatic activities responsible for these lesions have not been previously identified as critical determinants of overall sensitivity to the antitumor effects of these agents. The purpose of this study was to determine whether differences in uracil misincorporation/misrepair could account for the difference in sensitivity to fluorodeoxyuridine (FdUrd)-induced cytotoxicity and DNA damage in 2 human colorectal tumor cell lines having identical sensitivities to FdUrd-induced thymidylate synthase inhibition. Compared to HT29 cells, SW620 cells were resistant to both cytotoxicity and induction of DNA double-strand breaks, as assessed by pulse field gel electrophoresis. Alkaline elution experiments demonstrated that this resistance coincided with delayed induction of DNA single-strand breaks on parental DNA and, to a lesser extent, on nascent DNA. Following treatment with FdUrd for 24 h, HT29 cells accumulated 904 +/- 273 pmol deoxyuridine triphosphate (dUTP)/10(7) cells, whereas SW620 cells accumulated 20 +/- 7 pmol dUTP. Consistent with this difference in extent of dUTP accumulation was the observation that deoxyuridine triphosphatase levels in SW620 cellular extracts were 4.4-fold higher than in HT29 extracts. The ability to accumulate dUTP, intracellular deoxyuridine triphosphatase activity, and extent of DNA damage appear to be important determinants for predicting the response to FdUrd treatment in these cell lines.
A rectangular area filling display system architecture (1982)

A display system architecture which has rectangular area filling as its primitive operation is presented. It is shown that lines can be drawn significantly faster with this architecture than with a pixel display system. The rendition of filled boxes is also faster showing an O(n2) speed improvement. Furthermore filled polygons can be rendered with an O(n) speed improvement.
Oberhauswahl in Japan: frisches Mandat für die Regierung oder politischer Stillstand? (2010)

Gut zehn Monate nach dem historischen Machtwechsel in Tokyo entscheiden Japans Wahler in der Oberhauswahl am 11. Juli daruber, ob die Demokratische Partei Japans (DPJ) ihren Reformkurs in den kommenden Jahren fortsetzen kann. Wahrend die angeschlagene DPJ unter ihrem neuen Fuhrer Naoto Kan auf ein frisches Mandat hofft, will die oppositionelle Liberaldemokratische Partei (LDP) ihrem Niedergang bei der Wahl ein Ende setzen. Die Grundung einiger neuer Parteien hat allerdings das Feld der Bewerber deutlich unubersichtlicher gemacht.
Q-Learning for Driving on Infinite Road (2018)

The autonomous vehicles will consume large amounts of streaming data from nearby vehicles, infrastructure, and cloud to make decisions. The goal of the project is to adaptively change the velocity of a connected autonomous vehicle to minimize the fuel consumption of the vehicle. The vehicle will make real time decisions based on real-time information from V2X and V2V connectivity keeping in mind the constraints imposed by the powertrain of the vehicle. We aim at solving this problem using reinforcement learning algorithm. The ultimate goal of the project is to design and run very large scale reinforcement learning algorithm for devising fuel efficient driving strategies.
Computer-aided vision engineering (CAVE)-quantification of wear particle morphology (1994)

Microscopic wear particles transported by the lubricant from wear sites carry with them important information relating to the condition of machinery. Quantitative methods for determining the morphological attributes of particles have been established in terms of their size, shape, and surface texture. This paper reviews some of the developments that have taken place and describes the stages involved in processing the particles, including the use of a neural network system to classify particles in relation to different wear regimes. The development of a new interactive control system, CAVE, is described which is utilized in conjunction with image processing procedures. It is designed for use by researchers engaged in the study of wear processes and also for engineers involved in routine monitoring of wear processes in operating machinery. 30 refs., 3 figs., 3 tabs.
TIMER: Tumor IMmune Estimation Resource (2016)

TIMER is a resource for systematical evaluations of the clinical impact of different immune cells in diverse cancer types. The abundance of six immune cell types: B cell, CD4 T cell, CD8 T cell, neutrphil, macrophage and dendritic cell in the tumor microenvironment is estimated using a novel statistical method we have developed. The outcome of this method has been validated using pathological estimations.
608. The thermal decomposition of acetic acid (1949)

C. H. Bamford and M. J. S. Dewar, J. Chem. Soc., 1949, 2877 DOI: 10.1039/JR9490002877
Interferon-γ and Granulocyte/Monocyte Colony-stimulating Factor Production by Natural Killer Cells Involves Different Signaling Pathways and the Adaptor Stimulator of Interferon Genes (STING) (2013)

Natural killer (NK) cells are important for innate immunity in particular through the production of IFN-γ and GM-CSF. Both cytokines are important in restoration of immune function of tolerized leukocytes under inflammatory events. The expression of TLRs in NK cells has been widely studied by analyzing the mRNA of these receptors, rarely seeking their protein expression. We previously showed that murine spleen NK cells express TLR9 intracellularly and respond to CpG oligodeoxynucleotide (CpG-ODN) by producing IFN-γ and GM-CSF. However, to get such production the presence of accessory cytokines (such as IL-15 and IL-18) was required, whereas CpG-ODN or accessory cytokines alone did not induce IFN-γ or GM-CSF. We show here that TLR9 overlaps with the Golgi apparatus in NK cells. Furthermore, CpG-ODN stimulation in the presence of accessory cytokines induces the phosphorylation of c-Jun, STAT3, and IκBα. IFN-γ and GM-CSF production requires NF-κB and STAT3 activation as well as Erk-dependent mechanisms for IFN-γ and p38 signaling for GM-CSF. Using knock-out-mice, we show that UNC93b1 and IL-12 (produced by NK cells themselves) are also necessary for IFN-γ and GM-CSF production. IFN-γ production was found to be MyD88- and TLR9-dependent, whereas GM-CSF was TLR9-independent but dependent on STING (stimulator of interferon genes), a cytosolic adaptor recently described for DNA sensing. Our study thereby allows us to gain insight into the mechanisms of synergy between accessory cytokines and CpG-ODN in NK cells. It also identifies a new and alternative signaling pathway for CpG-ODN in murine NK cells.
Condensed Cyclobutane Aromatic Compounds. VIII. The Mechanism of Formation of 1,2-Dibromobenzocyclobutene; A New Diels-Alder Synthesis (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensed Cyclobutane Aromatic Compounds. VIII. The Mechanism of Formation of 1,2-Dibromobenzocyclobutene; A New Diels-Alder SynthesisM. P. Cava, A. A. Deana, and K. MuthCite this: J. Am. Chem. Soc. 1959, 81, 24, 6458–6460Publication Date (Print):December 1, 1959Publication History Published online1 May 2002Published inissue 1 December 1959https://pubs.acs.org/doi/10.1021/ja01533a032https://doi.org/10.1021/ja01533a032research-articleACS PublicationsRequest reuse permissionsArticle Views1167Altmetric-Citations104LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recombinant, tumour-derived idiotype vaccination for indolent B cell non-Hodgkin’s lymphomas: a focus on FavId™ (2005)

FavId (Favrille, Inc., San Diego, CA, USA) is a personalized therapeutic vaccine product for B cell non-Hodgkin's lymphoma, custom-manufactured from individual patient's tumour cells. This investigational agent consists of recombinant tumour-specific immunoglobulin (idiotype [Id]) chemically conjugated to the highly immunogenic carrier protein keyhole limpet haemocyanin (Id-KLH). The vaccine product is administered by subcutaneous co-injection with the cytokine adjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF) with the goal of stimulating tumour-specific T cell and humoral immunity. Therapeutic Id vaccines have shown promising results in early phase clinical trials in follicular lymphoma, and several Phase III trials are ongoing. FavId's advantages over other Id vaccine formulations include its rapid and efficient manufacturing technology utilising recombinant baculovirus, with a production time of only 8-12 weeks. In Phase II studies, FavId Id-KLH plus GM-CSF vaccines have been found to be safe, immunogenic and clinically active in follicular lymphoma. At present, FavId is being tested in a randomised, placebo-controlled Phase III trial in follicular lymphoma, aimed at improving the time to disease progression when administered following cytoreduction with rituximab. If found to be efficacious in this pivotal trial, FavId would represent a tumour-selective immunotherapy for lymphoma with little toxicity and a novel mechanism of action.
<i>Campylobacter jejuni</i>in broilers: the role of vertical transmission (1986)

The role of broiler eggs in the transmission of Campylobacter jejuni to broiler grow-out flocks was investigated. Six breeder flocks supplying broiler eggs to hatcheries were examined for cloacal carriage of C. jejuni. Of 240 birds tested, 178 (74%) were C. jejuni-positive. Eggs from these birds examined for C. jejuni penetration of the egg shell indicated that 185 of 187 were campylobacter-free. Eggs from breeder flocks of unknown C. jejuni status were also examined for C. jejuni shell penetration. C. jejuni was not isolated from 142 eggs examined. A further 193 hatchery eggs incubated and hatched in the laboratory were campylobacter-free. Six farms containing the progeny of C. jejuni-positive breeder flocks were monitored. Eight hundred and forty birds from 14 flocks in these grow-out farms were campylobacter-free during their 6-week grow-out period. Experimental egg-penetration studies indicated that C. jejuni transmission via the egg is not easily effected. Of 257 eggs surface-challenged with C. jejuni, 162 hatched; all were campylobacter-free. Of 167 eggs injected with C. jejuni, 12 hatched; 2 of these were colonized with C. jejuni. Our data do not support a role for vertical transmission of C. jejuni in commercial broiler production.
Supercoils in prokaryotic DNA restrained in vivo. (1980)

Cells of Escherichia coli containing the plasmid F were gamma-irradiated with various doses to introduce determined numbers of single-strand breaks in the F DNA. The cells were then incubated to permit repair of the breaks while DNA gyrase was inhibited with coumermycin to limit restoration of any relaxed supercoil. Repaired, covalently continuous F DNA was isolated and its superhelical density was measured by two different methods. Both indicated that a major part (50-60%) of the negative superhelical turns were maintained in the repaired molecules, suggesting that the supercoils are restrained in vivo.
Low-complexity subspace selection for partial adaptivity (2002)

This paper introduces low-complexity frequency domain approximations of optimal partially adaptive sensor array processors for space communications. Space-segment sensor arrays, for military and other critical communications links, require adaptivity to provide ECCM and mitigate interference. The size, weight, and power restrictions of such platforms, however, prohibit full adaptivity. The design of low-complexity reduced-rank processors are investigated in this paper. It is demonstrated that the performance of full-rank adaptive arrays is obtainable by low-rank processors through the use of frequency domain implementations of a cross-spectral metric.
A Biologic Velcro Patch (2015)

Mutated COL7A1 causes epidermolysis bullosa. Genetically corrected, patient-specific stem cells secreted nonmutant type VII collagen and generated stratified epithelium in a mouse model.
The beta‐carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells (2009)

Multidrug resistance (MDR), mediated by highly expressed ABC transporters, is one of the most important mechanisms in tumor cells. Breast cancer resistance protein (BCRP) is a member of the ABC transporter family. This transporter expels different kinds of lipophilic anticancer drugs, which have diffused into the cells. In this study, 96-well plate based assays and flow cytometry analysis were employed to screen natural products for BCRP inhibition. The beta-carboline alkaloid harmine inhibited BCRP in a BCRP overexpressing breast cancer cell line (MDA-MB-231). Harmine reduced resistance to the anticancer drugs mitoxantrone and camptothecin mediated by BCRP and might be an interesting new reversal agent. Harmine did not inhibit P-glycoprotein (P-gp) mediated drug efflux.
Spatially distributed p-n heterojunction based on nanoporous TiO2 and CuSCN (1999)

Directed semiconductor growth in nanoporous ceramic films is reported. A p-n heterojunction with an interface that is spatially distributed across the complete thickness of the ceramic film is established. The interface area is estimated to be several 100 times larger than its geometric projection. The p-n junction shows excellent rectification and may serve as the basic building block for photovoltaic devices.
Effects of Hypertonic Saline Hydroxyethyl Starch Solution and Mannitol in Patients With Increased Intracranial Pressure After Stroke (1998)

Infusion of 40 g mannitol and 100 mL HS-HES decreases increased ICP after stroke. The maximum effect occurs after the end of infusion and is visible over 4 hours. HS-HES seems to lower ICP more effectively but does not increase CPP as much as does mannitol.
Investigation of a Tuneable Mode-Locked Fiber Laser for Application to Multipoint Gas Spectroscopy (2004)

This paper reports on an initial investigation into the operation of a mode-locked fiber laser system for application in gas spectroscopy as a multipoint multigas sensor. Wavelength selection is performed by use of multiple chirped gratings and fine tuning by using the dispersion properties of the chirped gratings. A tuning rate of /spl sim/0.014 nm per kHz change in mode-lock frequency (at the third harmonic) has been demonstrated, which is suitable for scanning across gas absorption lines. Key issues that have an important bearing on the tuning are discussed, including gain flattening and polarization drift. This paper investigates a method of multiplexing the sensor cells with the mode-locked system. Preliminary results for a two cavity system are presented to verify the principles of the technique.
Detector channel design for a computerised tomograph (1984)

The electronic circuit associated with each X-ray detector in the front end of a computerised tomograph must fulfil very stringent requirements concerning its dynamic range, accuracy and noise contribution. Starting from input signal considerations under extreme conditions, those requirements are analysed and the use of a scintillator followed by a Si photodiode is considered. A novel circuit approach using an optocoupler for range switching between two integrators is adopted, that meets all the requirements. A prototype, with a built-in calibration circuit and associated logic, was built and tested for dynamic range and noise performance. The results were compared with those expected from the design calculations and found to be satisfactory.
Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolines and quinazolinethiones (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolines and quinazolinethionesR. V. Coombs, R. P. Danna, M. Denzer, G. E. Hardtmann, B. Huegi, G. Koletar, J. Koletar, H. Ott, E. Jukniewicz, and Cite this: J. Med. Chem. 1973, 16, 11, 1237–1245Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/jm00269a006https://doi.org/10.1021/jm00269a006research-articleACS PublicationsRequest reuse permissionsArticle Views341Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts