gebhart/patrepeval huggingface dataset:
Calcyclin Mediates Serum Response Element (SRE) Activation by an Osteoblastic Extracellular Cation-Sensing Mechanism (2003)

We identified calcyclin (S100A6), a calcium-binding protein of the EF-hand type belonging to the S100 family, as being responsible for transferring a cation-sensing response from osteoblasts to COS-7 cells. Transfection of the calcyclin cDNA into COS-7 and HEK-293 cells confirmed that the overexpression of calcylin caused these cells to gain the ability to sense extracellular cations, including aluminum, gadolinium, calcium, and magnesium. Conversely, we found that an antisense calcyclin construct reduced calcyclin expression and partially inhibited the cation-sensing response in MC3T3-E1 osteoblasts. These results implicate calcyclin in the activation of SRE and establish a role for calcyclin as an accessory protein involved in the cation-sensing pathway in osteoblasts.
Glow discharge mass spectrometry: a current assessment (1988)

Glow discharge mass spectrometry has reached a general stage of acceptance in numerous analytical laboratories. It has proved to be fairly sensitive for direct solids elemental analysis, exhibits a broad dynamic range and is relatively free from matrix effects. As a result, it is rapidly replacing other methods for the analysis of solids. However, serious problems may result from spectral interferences if the analyst is not alert to such possibilities. These interferences can be minimised or removed by any one of several approaches, depending upon the type and extent of the problem. In this overview of glow discharge mass spectrometry, the original hopes and expectations of the technique are compared with its current level of maturity and the available projections for its possible future role in trace element analysis.
Control of the Transformation Temperatures of TiNi Shape Memory Alloys by Ternary Additions (1990)

TiNi can successfully be used as a shape memory alloy in various applications. In specific cases, special demands are made on the transformation temperatures. In medical sciences, very well defined transformation temperatures are required. Branches like automobile industry require high transformation temperatures, i.e. 160°C or higher. To meet with those requirements, many investigations need still to be done. Since the transformation temperatures are extremely sensitive to thermomechanical treatment and variations in concentrations of the constituting elements and of impurities, it is difficult to control those temperatures without the basic understanding of the mechanisms involved. The purpose of the current investigation is to understand the influence of ternary additions to the TiNi alloy. A model will be proposed, on basis of which it will be possible to make TiNi shape memory alloys with pre-established transformation temperatures by choosing the right combinations of elements, thereby taking into account the price, shape memory properties and the workability of the resulting alloys. It may also be possible that this understanding leads to alloys that are less sensitive to thermomechanical treatment and concentration variations so that alloys with well defined transformation temperatures are easier to prepare.
RFID 기반의 모바일 의료정보시스템의 설계 및 구현 (2005)

최근의 의료정책과 정보기술의 발달은 병원이 주변 환경에 맞춰 비용을 줄이고 의료의 질을 향상시킬 필요를 가지게 한다. 즉, 정책과 기술의 변화로 병원 업무가 단순한 진료비 계산과 보험청구중심에서 벗어나 경영정보시스템(MIS), 의료영상저장전송시스템(PACS), 처방전달시스템(OCS), 자의무기록시스템(EMR), 의사결정지원시스템(DSS) 등이 개발되고...
ChemInform Abstract: 2‐Fluoro‐4‐pyridinylmethyl Analogues of Linopirdine as Orally Active Acetylcholine Release‐Enhancing Agents with Good Efficacy and Duration of Action. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Three Cases of Invasive Meningococcal Disease Caused by a Capsule Null Locus Strain Circulating among Healthy Carriers in Burkina Faso (2007)

During reinforced surveillance of acute bacterial meningitis in Burkina Faso, meningococcal strains of phenotype NG:NT:NST were isolated from cerebrospinal fluid samples from 3 patients. The strains were negative for the ctrA gene but were positive for the crgA gene. Molecular typing revealed that the strains harbored the capsule null locus (cnl) and belonged to the multilocus sequence type (ST)-192. PorA sequencing showed that all strains were either P1.18-11,42; P1.18,42-1; P1.18-11,42-1; P1.18-11,42-3; or P1.18-12,42-1. Sequencing also showed that all strains were negative for the FetA receptor gene. Serum killing assays showed these strains to be resistant, with the resistance comparable with that of a fully capsular serogroup B strain, MC58. The same strains were found in 14 healthy carriers in the general population of Bobo-Dioulasso (100% of ST-192 isolates tested for cnl). The presence of cnl meningococci that can escape serum killing and cause invasive disease is of concern for future vaccination strategies and should promote rigorous surveillance of cnl meningococcal disease.
Novel Agents in the Therapy of Hodgkin Lymphoma (2015)

Hodgkin lymphoma (HL) is a B-cell malignancy that typically has a favorable prognosis when treated with chemotherapy, often in combination with radiation therapy. The prognosis for patients whose disease relapses or is refractory, however, is far less favorable and novel therapies are needed for these patients. The unique cellular composition of HL provides a number of opportunities to target either the malignant Reed-Sternberg cell or the inflammatory tumor microenvironment. Antibody-drug conjugates targeting CD30, small molecule inhibitors of cell signaling, and antibodies that inhibit immune checkpoints, have all demonstrated activity in HL. Current and future trials are exploring the use of these agents in combination with each other and with standard chemotherapy.
Novel sorting network-based architectures for rank order filters (1994)

This paper presents two novel sorting network-based architectures for computing high sample rate nonrecursive rank order filters. The proposed architectures consist of significantly fewer comparators than existing sorting network-based architectures that are based on bubble-sort and Batcher's odd-even merge sort. The reduction in the number of comparators is obtained by sorting the columns of the window only once, and by merging the sorted columns in a way such that the number of candidate elements for the output is very small. The number of comparators per output is reduced even further by processing a block of outputs at a time. Block processing procedures that exploit the computational overlap between consecutive windows are developed for both the proposed networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Heterogeneous Decomposition of Silane in a Fixed Bed Reactor (1982)

Heterogeneous decomposition of silane in a fluidized bed offers an attractive route for the low‐cost production of silicon for photovoltaic application. To obtain design data for a fluid bed silane pyrolysis reactor, deposition experiments were conducted in a small‐scale fixed bed apparatus. Data on the decomposition mode, plating rate, and deposition morphology were obtained in the temperature range 600°–900°C. Conditions favorable for heterogeneous decomposition with good deposition morphology were identified. The kinetic rate data showed the reaction to be first order with an activation energy of 38.8 kcal/mol, which agrees well with work done by others. The results are promising for the development of an economically attractive fluid bed process.
Artificial Molecular Machines (2015)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTArtificial Molecular MachinesSundus Erbas-Cakmak, David A. Leigh*, Charlie T. McTernan, and Alina L. NussbaumerView Author Information School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 18, 10081–10206Publication Date (Web):September 8, 2015Publication History Received29 March 2015Published online8 September 2015Published inissue 23 September 2015https://doi.org/10.1021/acs.chemrev.5b00146Copyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoicewith CC-BYlicenseArticle Views68275Altmetric-Citations1351LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (62 MB) Get e-AlertsSUBJECTS:Macrocycles,Molecular structure,Molecules,Potential energy,Rotaxanes Get e-Alerts
Gene Structure of the Murine Calcium Channel β3 Subunit, cDNA and Characterization of Alternative Splicing and Transcription Products (1996)

The beta3 subunit of high-voltage-gated calcium channels is a peripheral membrane protein that copurifies with neural N-type calcium channels. Murine genomic clones containing the full coding sequence of beta3 were isolated and the exons were mapped and sequenced. The murine calcium channel beta3 subunit is encoded by a unique gene composed of 13 translated exons that spread over approximately 8 kb of genomic sequence. Alternatively spliced transcripts of the beta3 gene were identified and characterized. The primary structure of beta3 is highly conserved between the murine, human, rabbit and rat proteins (98% identity). The intron placement within that primary structure correlates with the previously postulated exon positions in transcripts encoding the members of the calcium channel beta subunit family and confirm a close evolutionary relationship of the beta3, beta1, beta2 and beta4 subunit genes.
Properties of arsenic sulfide glass (1957)

Samples of ar~e n i c s ulfid e glaHS " -ere investigated to clc>lerll1ine the ir che m ical a nd phys ical properties. Amon g the proper ties r eported a re t ile hygros co pici t.I', chemi cal durability, hydroge n e lec trod e fUllc t ioll, ex pansivi ty , clastic nlOduli, modulus of rnpture', hardn ess, transmittance, and indices of re fraction .
Outer membrane protein profiles of Edwardsiella ictaluri from fish. (1990)

Outer membrane proteins (OMP) prepared with sodium N-lauroyl sarcocinate (SLS) from 33 Edwardsiella ictaluri isolates from fish were examined by electrophoresis. Twenty-eight isolates from channel catfish (Ictalurus punctatus) had similar OMP profiles. Ten bands (71 kilodaltons [kD] to 19.5 kD) were identified in all isolates from channel catfish. One major 35-kD protein comprised most of the protein content of the outer membrane of isolates from channel catfish. Differences existed among isolates in the amount of protein within minor OMP bands. Edwardsiella ictaluri ATCC 33202 contained larger quantities of the 38.5- and 37-kD proteins than did the other isolates. Outer membrane protein profiles of E ictaluri derived from Bengal danio (Danio devario) and walking catfish (Clarias batrachus) were identical to OMP profiles of isolates from channel catfish. In contrast, OMP profiles from single isolates from green knife fish (Eigemannia virescens) and white catfish (Ictalurus catus) were different. Variations in incubation time, SLS extraction time, SLS extraction number, and in vivo and in vitro passage had no effect on the OMP profile of E ictaluri ATCC 33202. An increase in duration of sample solubilization did affect the OMP profile of E ictaluri ATCC 33202 by decreasing the amount of protein in 52-, 46-, and 43.5-kD bands. Accompanying the decrease were increased staining intensity in the 31.5- and 28.5-kD bands and the appearance of 4 new bands (34, 33, 25.5, and 22.5 kD). Edwardsiella ictaluri, a gram-negative bacterium in the family Enterobacteriaceae, is the cause of enteric septicemia of catfish.(ABSTRACT TRUNCATED AT 250 WORDS)
Tonometry, Arterial (2006)

Abstract Arterial tonometry is a technique that permits the noninvasive monitoring of the pressure within a superficial artery, such as the radial artery at the wrist. The technique is based on an analysis showing that—under the proper conditions—the artery wall does not influence the transmission of arterial pressure to a sensor applied to the skin. Tonometer sensors have been devised that employ various transduction techniques. Perhaps the most advanced sensors include a multiplicity of independent pressure sensors, and are fabricated from silicon. Tonometric measurements have been used to monitor blood pressure during surgery and similar procedures. They have also been used to determine arterial elasticity and pulse wave velocity. Under favorable conditions, the accuracy of tonometric measurements can be described by standard deviations of ∼ 5 mmHg (0.66 kPa).
Weight Loss May Reverse Blunted Sympathetic Neural Responsiveness to Glucose Ingestion in Obese Subjects With Metabolic Syndrome (2009)

Weight loss reverses blunted sympathetic responsiveness to glucose ingestion in insulin-resistant subjects with metabolic syndrome, which is relevant to postprandial energy utilization and body weight homeostasis.
Structural organization of the human neuronal nitric oxide synthase gene (NOS1) (1994)

Neuronal nitric oxide (NO) synthase, localized to human chromosome 12, uniquely participates in diverse biologic processes; neurotransmission, the regulation of body fluid homeostasis, neuroendocrine physiology, control of smooth muscle motility, sexual function, and myocyte/myoblast biology, among others. Restriction enzyme mapping, subcloning, and DNA sequence analysis of bacteriophage- and yeast artificial chromosome-derived human genomic DNA indicated that the mRNA for neuronal NO synthase is dispersed over a minimum of 160 kilobases of human genomic DNA. Analysis of intron-exon splice junctions predicted that the open reading frame is encoded by 28 exons, with translation initiation and termination in exon 2 and exon 29, respectively. Determination of transcription initiation sites in brain poly(A) RNA with primer extension analysis and RNase protection revealed a major start site 28 nucleotides downstream from a TATA box. Sequence inspection of 5'-flanking regions revealed potential cis-acting DNA elements: AP-2, TEF-1/MCBF, CREB/ATF/c-Fos, NRF-1, Ets, NF-1, and NF-kappa B-like sequences. Diversity appears to represent a major theme apparent upon analysis of human neuronal NO synthase mRNA transcripts. A microsatellite of the dinucleotide variety was detected within the 3'-untranslated region of exon 29. Multiple alleles were evident in normal individuals indicating the existence of allelic mRNA sequence variation. Characterization of variant human neuronal NO synthase cDNAs indicated the existence of casette exon 9/10 and exon 10 deletions as examples of structural mRNA diversity due to alternative splicing. The latter deletion of a 175-nucleotide exon introduces a frame-shift and premature stop codon indicating the potential existence of a novel NH2 terminus protein. In summary, analysis of the human neuronal NO synthase locus reveals a complex genomic organization and mRNA diversity that is both allelic and structural.
Actigraphy to measure day structure as a therapeutic variable in the treatment of schizophrenic patients (2000)

Actigraphy could serve as a tool to investigate activity levels and circadian rest-activity phases, even in schizophrenia. There may be some further benefit of actigraphy as a tool in psychosocial treatments.
Intrathecal Spinal Progenitor Cell Transplantation for the Treatment of Neuropathic Pain (2002)

Injury to, or dysfunction of, the nervous system can lead to spontaneous pain, hyperalgesia, and/or allodynia. It is believed that the number and activity of GABAergic neurons gradually decreases over the dorsal horn. Glutamic acid decarboxylase (GAD) immunocompetence has been demonstrated on spinal progenitor cells (SPCs) cultivated in vitro. The intrathecal implantation of these cultivated progenitor cells may provide a means of alleviating neuropathic pain. Chronic constriction injury (CCI) of the sciatic nerve was used to induce chronic neuropathic pain in the hind paw of rats. SPCs (1 x 10(6)) were implanted intrathecally on the third day after the CCI surgery. The behavioral response to thermal hyperalgesia was observed and recorded during the 14 days postsurgery. Various techniques were utilized to trace the progenitor cells, confirm the differentiation, and identify the neurotransmitters involved. GAD immunoactivity was revealed for 65% of the cultivated spinal progenitor cells in our study. We also determined that transplanted cells could survive more than 3 weeks postintrathecal implantation. Significant reductions were demonstrated for responses to thermal stimuli for the CCI rats that had received intrathecal SPC transplantation. A novel intrathecal delivery with SPCs reduced CCI-induced neuropathic pain.
Advanced High Frequency AC Microgrid with integrated power quality conditioning capability (2009)

This paper presents a high frequency AC (HFAC) microgrid with power quality conditioning capacity, as an alternative energy conversion for integration of renewable energy sources in a distributed generation system. It is shown that successful implementation of any HFAC microgrid relies on the best utilization of the source and integrating bus, which can be accomplished by using a unified power quality conditioner (UQPC). The UPQC can simultaneously compensate for current and voltage harmonics and also for reactive power. Its controller is based on the modified instantaneous p-q theory and the results obtained show that this conditioner can be effectively used to improve the quality of power systems.
Magnetic poly (styrene/divinylbenzene/acrylic acid)-based hybrid microspheres for bio-molecular recognition (2011)

Polymer-iron hybrid magnetic microspheres with different carboxyl functionalisation for biomedical applications, thanks to suitable bio-recognition of the carcinoembryonic antigen (CEA), were prepared by the precipitation polymerisation of styrene-divinylbenzene-acrylic acid embedding iron oxide magnetic nanoparticles (∼10 nm). The influence of the acrylic acid concentration in the final size of copolymer and, consequently, in the efficiency of the antibody coupling between the primary amino group (–NH2) and the carboxyl functional groups (–COOH) in the polymeric surface were evaluated by varying monomers ratio with fixed content of magnetite nanoparticles. Particle size and morphology were investigated by scanning electronic microscopy and transmission electronic microscopy, as well as the saturation magnetisation values were measured in an electromagnet. The –COOH functionalisation and the covalent bounding of the antibodies, via detecting amino and carbonyl groups, were characterised by Fourier transform infrared spectroscopy. Regarding possible applications in molecular/cellular recognition and solid supports for immunoassays, efficient immobilisation of antibodies against CEA on particles surface via covalent bonding of the antibody and surface –COOH groups was demonstrated by immunochemistry techniques.
Food Additives from an Organic Chemistry Perspective (2017)

Food additives are an essential part of the contemporary food system, providing definite advantages in terms of people's way of life. Food additives have been used, investigated, regulated, and controlled all through history. Although many reports, books, monographs, articles, etc. are available on this topic, but only a few of them focus on catering primarily to an organic chemistry audience who has little or no prior exposure to systematic food additive chemistry. This report gives a brief historical and regulatory background followed by an overview of different types of food additives along with their properties and structures. The paper is roughly subdivided into the following categories: (a) introduction to food additives, (b) their brief historical background, (c) short introduction to the numbering and the approval process for additives, (d) a discussion of the categories of food additives from an organic chemists' perspective which forms the main bulk of the paper including, for example, categories such as acids, acidity regulators, antifoaming and anticaking agents, emulsifiers, flavors, etc., (e) comparison of organic vs synthetic foods and food safety issues, and (f) conclusion and future prospects.
Opportunistic Frequency Stability Transfer for Extending the Coherence Time of GNSS Receiver Clocks (2018)

A framework is presented for exploiting the frequency stability\nof non-GNSS signals to extend the coherence time\nof inexpensive GNSS receiver clocks. This is accomplished\nby leveraging stable ambient radio frequency signals, called\n“signals of opportunity,” to compensate for the frequency\ninstability of the reference oscillators typically used in inexpensive\nhandheld GNSS receivers. Adequate compensation\nfor this frequency instability permits the long coherent\nintegration intervals required to acquire and track GNSS\nsignals with low carrier-to-noise ratios. The goal of this\nwork is to push the use of GNSS deeper indoors or into\nenvironments where GNSS may be subject to interference.
4-Mb MOSFET-selected /spl mu/trench phase-change memory experimental chip (2005)

A /spl mu/trench Phase-Change Memory (PCM) cell with MOSFET selector and its integration in a 4-Mb experimental chip fabricated in 0.18-/spl mu/m CMOS technology are presented. A cascode bitline biasing scheme allows read and write voltages to be fed to the addressed storage elements with the required accuracy. The high-performance capabilities of PCM cells were experimentally investigated. A read access time of 45 ns was measured together with a write throughput of 5 MB/s, which represents an improved performance as compared to NOR Flash memories. Programmed cell current distributions on the 4-Mb array demonstrate an adequate working window and, together with first endurance measurements, assess the feasibility of PCMs in standard CMOS technology with few additional process modules.