gebhart/patrepeval huggingface dataset:
A data-driven VLSI array for arbitrary algorithms (1988)

The design of specialized processing array architectures, capable of executing any given arbitrary algorithm, is proposed. An approach is adopted in which the algorithm is first represented in the form of a dataflow graph and then mapped onto the specialized processor array. The processors in this array execute the operations included in the corresponding nodes (or subsets of nodes) of the dataflow graph, while regular interconnections of these elements serve as edges of the graph. To speed up the execution, the proposed array allows the generation of computation fronts and their cancellation at a later time, depending on the arriving data operands; thus it is called a data-driven array. The structure of the basic cell and its programming are examined. Some design details are presented for two selected blocks, the instruction memory and the flag array. A scheme for mapping a dataflow graph (program) onto a hexagonally connected array is described and analyzed. Two distinct performance measures-mapping efficiency and array utilization-and some performance results are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Object‐Oriented Development (2002)

Abstract The object‐oriented model for software development has become exceedingly attractive as the best answer to the increasingly complex needs of the software development community. What was first viewed by many as a research curiosity and an impractical approach to industrial strength software is now being enthusiastically embraced. Object‐oriented versions of most languages have been or are being developed. Numerous object‐oriented methodologies have been proposed. Conferences, seminars, and courses on object‐oriented topics are extremely popular. New journals and countless special issues of both academic and professional journals have been devoted to the subject. Contracts for software development that specify object‐oriented techniques and languages currently have a competitive edge. Object‐oriented development is to the 1990s what structured development was to the 1970s, and the object‐oriented movement is still accelerating. The object‐oriented model is more than a collection of new languages; it is a new way of thinking about what it means to compute and about how information can be structured. In the object‐oriented model, systems are viewed as cooperating objects that encapsulate structure and behavior and that belong to classes which are hierarchically constructed. All functionality is achieved by messages that are passed to and from objects. The object‐oriented model can be viewed as a conceptual framework with the following elements: abstraction, encapsulation, modularity, hierarchy, typing, concurrence, persistence, reusability, and extensibility. Programming and the use of object‐oriented language are discussed. Object‐oriented transition and the future and also discussed.
Monoclonal antibody production in dialyzed continuous suspension culture (1992)

Hybridoma cell growth and monoclonal antibody production in dialyzed continuous suspension culture were investigated using a 1.5-L Celligen bioreactor. Medium supplemented with 1.5% fetal bovine serum was fed directly into the reactor at a dilution rate of 0.45 d(-1). Dailysis tubing with a molecular weight cut-off (MWCO) of 1000 was coiled inside the bioreactor. Fresh medium containing no serum or serum substitutes passed through the dialysis tubing at flow rates of 2 to 5 L/d. The objective was to remove low molecular weight inhibitors, such as lactic acid and ammonia, by diffusion through the tubing, while continuously replenishing essential nutrients by the same mechanism. Due to the low MWCO of the dialysis tubing high molecular weight components such as growth factors and antibody were not removed by the dialyzing stream. In the batch start-up phase, the monoclonal antibody (MAb) titer was almost 3 times that achieved in typical batch cultures (i.e., 170 to 180 mg/L). During dialyzed continuous operation, a substantial increase (up to 40%) in cell density, monoclonal antibody (MAb) titer, and reactor MAb productivity was observed, as compared with a conventional continuous suspension culture. The cell viability and the specific MAb productivity remained practically constant at different dialysis rates. This finding suggests that the steady state growth and death rate in continuous suspension hybridoma cultures are not direct functions of the nutrient or inhibitor concentrations.
Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells (2004)

The activity of the de novo pyrimidine biosynthetic pathway in the MCF7 breast cancer cells was 4.4-fold higher than that in normal MCF10A breast cells. Moreover, while pyrimidine biosynthesis in MCF10A was tightly regulated, increasing as the culture matured and subsequently down-regulated in confluency, the biosynthetic rate in MCF7 cells remained elevated and invariant in all growth phases. The flux through the pathway is regulated by carbamoyl phosphate synthetase, a component of the multifunctional protein, CAD. The intracellular CAD concentration was 3.5- to 4-fold higher in MCF7 cells, an observation that explains the high rate of pyrimidine biosynthesis but cannot account for the lack of growth-dependent regulation. In MCF10A cells, up-regulation of the pathway in the exponential growth phase resulted from MAP kinase phosphorylation of CAD Thr456. The pathway was subsequently down-regulated by dephosphorylation of P approximately Thr456 and the phosphorylation of CAD by PKA. In contrast, the CAD P approximately Thr456 was persistently phosphorylated in MCF7 cells, while the PKA site remained unphosphorylated and consequently the activity of the pathway was elevated in all growth phases. In support of this interpretation, inhibition of MAP kinase in MCF7 cells decreased CAD P approximately Thr456, increased PKA phosphorylation and decreased pyrimidine biosynthesis. Conversely, transfection of MCF10A with constructs that elevated MAP kinase activity increased CAD P approximately Thr456 and the pyrimidine biosynthetic rate. The differences in the CAD phosphorylation state responsible for unregulated pyrimidine biosynthesis in MCF7 cells are likely to be a consequence of the elevated MAP kinase activity and the antagonism between MAP kinase- and PKA-mediated phosphorylations.
Reform and opportunity : the changing role and patterns of trade in South Africa and SADC (2001)

In this paper, we examine the changing role of trade in South Africa and SADC from different vantage points. We first review progress in liberalizing South Africa's trade regime, and conclude that, while signs of progress are clear, the levels and complexity of protection continue to pose barriers to the evolution of efficient trading patterns and a constraint to growth. We also find that trade liberalization has not led to de-industrialization of the South African economy: while import penetration has risen, exports have grown as well, so that the net impact from expanding trade is positive. But the net numbers remain small, and the limited employment creation is biased towards skilled workers, suggesting that the full potential from expanding trade has not been realized. We turn our focus next to the SADC region, and examine the fiscal implications of the proposed SADC FTA, highlighting both the administrative complexity of harmonizing tariff regimes among the diverse SADC economies, and the differential fiscal costs of the proposed arrangements for the participating economies. Finally, we look at the economic impact of alternative free trade areas (FTAs) for the region, using a multi-region simulation model. We find that these FTA initiatives are beneficial for the region, not only for participants, but even (in the case of the EU-South Africa FTA) for non-participants, since the rest of southern Africa benefits as well from the EU-South Africa agreement. But it is also clear that South Africa alone is not large enough to serve as the growth pole for the entire sub-region. Authors' Affiliation and Sponsorship Jeffrey D. Lewis, Lead Economist, AFTMI, The World Bank e-mail: jlewis4@worldbank.org THE WORKING PAPER SERIES The Africa Region Working Paper Series expedites dissemination of applied research and policy studies with potential for improving economic performance and social conditions in Sub-Saharan Africa. The Series publishes papers at preliminary stages to stimulate timely discussion within the Region and among client countries, donors, and the policy research community. The editorial board for the Series consists of representatives from professional Families appointed by the Region's Sector Directors. Editor in charge of the series: Antoine Waldburger, AFTM3, Email: awaldburger@worldbank.org, who may be contacted for hard copies. For additional information visit the Web site http://www.worldbank.org/afr/wps/index.htm, where copies are available in pdf format. The findings, interpretations, and conclusions expressed in this paper are entirely those of the author(s). They do not necessarily represent the views of the World Bank Group, its Executive Directors, or the countries that they represent and should not be attributed to them. Reform and Opportunity: The Changing Role and Patterns of Trade in South Africa and SADC Jeffrey D. Lewis Lead Economist, AFTM1, The World Bank e-mail: jlewis4gworldbank.org
1480 nm pumped erbium doped fibre amplifier withall optical automatic gain control (1994)

A 15 dB, gain controlled, 1480 nm pumped, erbium doped silica fibre amplifier is demonstrated with < 0.2 dB of gain variation for signal input levels up to –5 dBm. Gain control is effected by concomitant lasing at 1520 nm using Bragg grating reflectors. No error rate penalty is observed for a signal modulated at 2.5 Gbit/s.
Reduced-Rate OFDM Transmission for Inter-Subchannel Interference Self-Cancellation over High-Mobility Fading Channels (2012)

In this paper, we develop a general reduced-rate orthogonal frequency division multiplexing (OFDM) transmission scheme for inter-subchannel interference (ICI) self-cancellation over high-mobility fading channels. Via transmit and receive processing, we transform the original OFDM system into an equivalent one with fewer subcarriers. By reducing transmission rate, we are able to design a transmitted signal structure with inherent ICI self-cancellation capability without requiring the instantaneous channel state information. We develop a general structure of transmit and receive processing matrices so that all equivalent subchannels in the transformed OFDM system have the same average signal-to-interference ratio (SIR). For the developed structure, we further optimize the transmit and the receive processing coefficients to maximize the SIR based on channel statistics. Numerical and simulation results demonstrate that the developed reduced-rate OFDM transmission achieves an SIR gain of around 5 dB over the existing ICI self-cancellation schemes and significantly reduces the error floor at the receiver.
A two-colour near-infrared sensor for sorting recycled plastic waste (1995)

This paper describes a simple device for automated sorting of post-consumer plastic waste. It is shown that rapid and reliable identification of certain polymers can be achieved by using a simple two-colour fixed filter near-infrared spectrometer in conjunction with a simple ratio circuit. The effectiveness of the proposed method is demonstrated in sorting of polyethylene terephthalate and polyvinyl chloride. A sensor based on this identification method is inexpensive to build and provides the necessary speed and performance required by the recycling industry.
High power linear AC Electronic Load for testing UPS Systems (2007)

Concept of a series bipolar transistor array for AC power control is already developed. However non-linearity issues, high power capability with load sharing at high voltages and digital control with better transient performance were not adequately adopted in early-developed stages.\n\nThis thesis is a description of the design approach of digitally controllable linear 230V/50 Hz AC line voltage capable electronic load with predictable characteristics based on spice simulation. The BJT array used in this project provides high power dissipation capability and uniform voltage and power distribution across the individual transistors. A set of optoisolators are used to have electrical isolation between power stage and digital control circuits. A Zilog Z8Encore! 64K series development kit is used in controlling the circuit.
A New Aggregation Method for Determining Composite Load Characteristics (1982)

A new aggregation method for deteining load characteristics for representation in computer simulations is proposed. In support of the new method, a mathematical derivation is presented. Also, results are compared with models obtained by using the EPRI/University of Texas at Arlington method and field tests. The application of the proposed method is simpler than existing methods in that it does not require field tests or the use of curve fitting techniques. The procedure should be of primary interest to transmission system planners involved in load flow and dynamic stability simulations of power systems.
Armature current locus based estimation method of rotor position of permanent magnet synchronous motor without mechanical sensor (1995)

This paper describes a new method of estimating the initial rotor position of a permanent magnet (PM) motor without turning the rotor. At the stand still, the saliency of the PM motor makes the locus of the armature current-vector an oval when the armature voltage is a 3-phase balanced sine wave applied by a PWM inverter. The major diameter direction of the current-vector locus gives information on the rotor direction. The shift of the current-vector locus caused by magnetic saturation makes it possible to identify the direction of the rotor magnet N-pole. The proposed method to estimate the rotor position was verified by experimental results of a 100 W PM motor.
The Molecular Basis of Salivary Gland Involvement in Graft-<i>vs.</i>-Host Disease (2004)

During the past two decades, the involvement of salivary glands in graft vs. host disease (GVHD) had been intensively researched and published. GVHD occurs in 40-70% of patients treated with bone marrow and peripheral blood stem cell transplantation (PBSCT), and improved survival rates have led to a continuously increasing number of GVHD patients suffering from induced salivary insult. Limited studies suggest that a large percentage of GVHD patients is affected and that the induced salivary dysfunction occurs rapidly following the transplantation. It affects both major and minor salivary glands and reflects the severity of the disease. Moreover, profound sialochemical alterations may be diagnostic of GVHD. An additional reason for this vast research is that GVHD, as an autoimmune-like disease, seemed to be an appropriate model for studying a much more prevalent and well-known and well-studied autoimmune disease involving salivary glands: Sjögren's syndrome. The purpose of the current review-which is, to the best of our knowledge, the first of its kind-is to describe the GVHD-related sialometric and sialochemical data published in the past two decades for both major and minor salivary glands and to discuss the pathogenesis and molecular basis of the disease.
Detailed design and evaluation of redundant multi-threading alternatives (2003)

Exponential growth in the number of on-chip transistors, coupled. with reductions in. voltage levels, makes each generation of microprocessors increasingly vulnerable to transient faults. In a multi-threaded environment, we can detect these faults by running two copies of the same program as separate threads, feeding them identical inputs, and comparing their outputs, a technique we call redundant multi-threading (RMT). This paper studies RMT techniques in the context of both single- and dual-processor simultaneous multi-threaded (SMT) single-chip devices. Using a detailed, commercial-grade, SMT processor design we uncover subtle RMT implementation complexities, and find that RMT can be a more significant burden for single-processor devices than prior studies indicate. However, a novel application of RMT techniques in a dual-processor device, which we term chip-level redundant threading, shows higher performance than lock-stepping the two cores, especially on multi-threaded workloads.
Lattice-based flow field modeling (2004)

We present an approach for simulating the natural dynamics that emerge from the interaction between a flow field and immersed objects. We model the flow field using the Lattice Boltzmann Model (LBM) with boundary conditions appropriate for moving objects and accelerate the computation on commodity graphics hardware (GPU) to achieve real-time performance. The boundary conditions mediate the exchange of momentum between the flow field and the moving objects resulting in forces exerted by the flow on the objects as well as the back-coupling on the flow. We demonstrate our approach using soap bubbles and a feather. The soap bubbles illustrate Fresnel reflection, reveal the dynamics of the unseen flow field in which they travel, and display spherical harmonics in their undulations. Our simulation allows the user to directly interact with the flow field to influence the dynamics in real time. The free feather flutters and gyrates in response to lift and drag forces created by its motion relative to the flow. Vortices are created as the free feather falls in an otherwise quiescent flow.
The use of the QR factorization in the partial realization problem (1987)

The use of the QR factorization of the Hankel matrix in solving the partial realization problem is analyzed. Straightforward use of the QR factorization results in a realization scheme that possesses all of the computational advantages of Rissanen's realization scheme. These latter properties are computational efficiency, recursiveness, use of limited computer memory, and the realization of a system triplet having a condensed structure. Moreover, this scheme is robust when the order of the system corresponds to the rank of the Hankel matrix. When this latter condition is violated, an approximate realization could be determined via the QR factorization. In this second scheme, the given Hankel matrix is approximated by a low-rank non-Hankel matrix. Furthermore, it is demonstrated that column pivoting might be incorporated in this second scheme. The results presented are derived for a single input/single output system, but this does not seem to be a restriction.
ChemInform Abstract: THE ADDITION OF ALKYLLITHIUM REAGENTS TO TRANS‐CYCLOOCTENE, THE FACILE ELIMINATION OF LITHIUM HYDRIDE IN THE CYCLOOCTYL RING (1974)

Abstract F′! trans‐Cycloocten (I) reagiert im Gegensatz zu cis‐Cycloocten mit tert.‐bzw. sek.‐ Butyllithium (II) in einer syn‐Addition zu den Verbindungen (III), die unter Verlust von LiH zu den Butylcyclooctenen (IV) und (V) und unter Aufnahme von HÜ′) zu Butylcyclooctanen (VI) umgesetzt werden.
Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. (1984)

A base substitution (C----T) at position -88 relative to the cap site was identified in the beta-globin gene cloned from an individual with a mild form of beta-thalassemia. This nucleotide change lies in the sequence ACACCC proposed as a distal promoter element. Transient expression of the mutant gene in HeLa cells revealed a modest deficit in beta-globin mRNA production. RNA processing was normal. The -88 beta-thalassemia mutation lends further support for the in vivo role of the distal element in transcription.
Critical role of Rho in cell transformation by oncogenic Ras. (1995)

We demonstrate that Rho, a regulator of cytoskeletal actin, is necessary for Ras transformation. A dominant inhibitory Rho gene (RhoBN19) specifically suppressed Rat1 cell focus formation induced by oncogenic Ras but not by Raf. An activated Rho gene (RhoBV14) lacked focus formation activity but augmented the focus formation activity of both oncogenes. NIH3T3 cell lines expressing RhoBV14 grew to higher saturation density and displayed reduced serum and anchorage requirements for growth. We concluded that Rho played a role in cell growth regulation and was required for transformation by oncogenic Ras but not Raf. A model for Ras signal transduction proposing separate Rho-dependent and Raf-dependent pathways is discussed.
Seasonal Variation of <i>Ralstonia solanacearum</i> Biovar 2 Populations in a Spanish River: Recovery of Stressed Cells at Low Temperatures (2005)

The presence of Ralstonia solanacearum biovar 2 in the watercourses of European countries is increasing, but little is known about its ecology in aquatic habitats. The detection of this pathogen in 2000 in one Spanish river led us to study its population density at different locations on the river over a period of 3 years. During 2000 and 2001, the pathogen was recovered at low densities (10 to 80 CFU/ml) by direct plating on modified SMSA agar from water samples at 14 degrees C or higher, but its isolation was usually unsuccessful at temperatures below 9 degrees C. To monitor the pathogen's abundance in winter, we used two liquid selective media for enrichment (at 29 and 35 degrees C) and compared them by using spiked river water samples: modified Wilbrink broth (MWB) was more efficient than modified SMSA broth for double-antibody-sandwich indirect enzyme-linked immunosorbent assay (DASI-ELISA) detection of R. solanacearum. Enrichment in MWB at both temperatures allowed us to recover R. solanacearum cells that were nonculturable on solid media up to 25 days after their entry into the viable but nonculturable state. When we applied this technique to water samples during the cold months of 2001 and 2002, we obtained the best detection results by the most-probable-number method after enrichment at 35 degrees C with MWB. The enrichment protocol was combined with DASI-ELISA and validated by Co-PCR to detect both naturally and artificially starved and cold-stressed cells in water, which were still infective. Overall, the data from this study demonstrate the effects of temperature variation on the population and culturability of R. solanacearum cells on solid media and their survival at low temperatures.
The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat (2003)

The objective of the research was to determine the effect of the type, dose, and volume of anti-fibrinolytic agents (tranexamic acid, aprotinin) added to fibrin formulations, on adhesion development. Adhesions were induced in 228 male rats by creating apposing parietal and visceral peritoneal defects. Animals were randomized to receive no treatment or a fibrin formulation containing aprotinin or tranexamic acid. Seven days later the incidence of adhesions, and the force and energy required to detach them, were determined. Adhesions developed in 13/13 rats in the control and aprotinin groups. Treatment with fibrin (100 mg/ml tranexamic acid) resulted in adhesions in 4/14 rats (as strips, p < or = 0.0005), 4/10 rats (as spray, p < or = 0.0036), and 12/15 rats (by drip). The reduction of adhesions was dependent on the concentration of tranexamic acid with strip and spray application. Using commercial formulations, tranexamic-acid-containing fibrin (10/15, p = 0.042), but not aprotinin-containing fibrin (13/15), reduced the incidence of side-wall adhesions from 15/15 in controls. Fibrin containing either tranexamic or aprotinin reduced the incidence and severity of adhesions. This effect was greater when tranexamic acid was used and was dependent on the mode of administration, the volume, and to a degree, the concentration of tranexamic acid.