gebhart/patrepeval huggingface dataset:
A real-index guided InGaAlP visible laser diode with a small beam astigmatism (1990)

The objective of this work is to realize a low-astigmatism InGaAP visible laser diode by using a self-aligned real-index guided structure.
A distributed image processing environment VIOS III and it's performance evaluation (2002)

We proposed a distributed image processing environment VIOS. In this paper, the third version, VIOS III is proposed. In VIOS III, a new parallel processing language VPE-p which has flexible syntax for describing parallel algorithms has been developed. The new programmable buffer for accessing global variables through a local area network is also proposed. The description ability for parallel image processing algorithms and processing performance using workstation clusters and a multi processor system are investigated by several image processing and recognition algorithms.
Dynamic behavior of twisted nematic liquid-crystal layers in switched fields (1975)

The Ericksen-Leslie equations, describing the dynamic behavior of nematic liquid crystals, have been applied to a twisted nematic layer and have been numerically solved for a number of cases. The results account well for the observed dynamic behavior of displays using a twisted nematic layer. In particular, an explanation is given for the ’’bounce’’ in the optical transmission of a twisted nematic cell between polarizers after switching off the applied field. Materials having a frequency dependence of the sign of the dielectric anisotropy show a reversal of twist after the frequency of the applied field has been switched. This can also be explained. It is shown that fluid motion is essential to the occurrence of these phenomena.
Solvent Interactions Stabilize the Polyproline II Conformation of Glycosylated Oligoprolines (2013)

In nature, proline residues carry several post-translational modifications (PTMs), including 4R hydroxylation and glycosylation. A recent study synthesized contiguously hydroxylated and glycosylated nonaproline peptides and revealed that both PTMs lead to a significant increase in the thermal stability of PPII relative to the unmodified oligoproline. The increased stability of the hydroxylated peptide can be explained by increased stability of the trans isomer due to stereoelectronic effects. However, the effects of glycosylation cannot be completely explained by stereoelectronics since previous experimental results indicate that 4R-glycosylation does not produce observable changes in the trans preference compared to 4R-hydroxylation. We therefore used sophisticated molecular modeling techniques to determine the reason for the further increase in thermal stability upon glycosylation. Free energy estimates obtained from adaptively biased molecular dynamics calculations in implicit (explicit) solvent are -9 kcal mol(-1) (-20 kcal mol(-1)) for the hydroxylated compound and -9 kcal mol(-1) (-46 kcal mol(-1)) for the glycosylated compound, indicating that direct solvent-peptide interactions are vital for explaining the glycosylation effects on PPII stability. Our data reveals for the first time that interactions between the hydroxyl groups in the glycosylated compound and water act in a complementary fashion with stereoelectronic effects to stabilize the PPII conformation in these substituted oligoproline peptides.
A Comparison of Two Emergency Cricothyroidotomy Kits in Human Cadavers (2008)

In this model, despite a shorter insertion time, the NT produced more lesions and more failures than the ST.
Molecular Recognition Studies Based on Imprinting Technology (1998)

In this thesis, I have focused on five main research areas: 1). A new type of imprinted polymer has been developed, namely the amide MIP. The amide functional monomers showed better hydrogen bonding capabilities in polar organic solvents and the resulting polymers exhibited good enantiomeric recognition properties in organic media. Furthermore, by using the amide monomers instead of the carboxyl monomers, imprinted polymers could be prepared without the excess of charged groups which often leads to the problem of swelling and non-specific interactions. 2). By using the amide MIPs, the recognition mechanism of imprinted polymers has been studied in detail. It was found that the shape, size and the nature and distribution of the functional groups of the sample molecule all had a marked influence on the selectivity. 3). The solvent effect was also studied, it was found that the recognition properties of imprinted polymers could be dramatically influenced by the assay solvent system used. By using a simply optimized solvent system, our results showed that the imprinted polymers? recognition performances could be greatly improved compared with the results obtained previously. 4). The amide MIPs were also found to be capable of selective recognition in aqueous media. Our results showed that the selective binding in organic media by imprinted polymers was mainly determined by the polar interactions between the sample molecules and the recognition sites, whereas in aqueous media, hydrophobic interactions played a major role. 5). Attempts have also been made to use imprinted polymers to separate chiral compounds, as enzyme and receptor mimics and to make imprinted polymer beads in aqueous media.
Development and field testing of a novel patient-reported outcome measure of dysphagia in patients with eosinophilic esophagitis (2013)

The DSQ, a three-question patient-reported outcome, was successfully developed and field tested. The DSQ had content validity and the score accurately measured dysphagia frequency and intensity. The Dysphagia Symptom Questionnaire is suitable for use in clinical trials of EoE patients with dysphagia.
Pharmacokinetics and bioavailability of three different galenic nifedipine preparations. (1986)

In a randomized three-way crossover study with twelve volunteers the bioavailability and main pharmacokinetic parameters of three different galenic formulations of nifedipine (hard gelatine capsule with pellets = preparation A, soft gelatine capsule with liquid nifedipine = preparation B, retard-tablet = preparation C) were determined. Plasma concentrations of nifedipine were measured by capillary gas-liquid chromatography up to 24 h after single dosing as well as up to 48 h after multiple doses of the drugs (steady state). Statistically significant differences between the preparations were found for AUC, Cmax, and Tmax. In all respects preparation A was intermediate to the other preparations. Plasma levels of 40 ng/ml or more were reached for most subjects within the first half hour after application of a single dose of preparation A and under steady state conditions plasma concentrations of 25 ng/ml or more could be upheld with this preparation for a longer time than with the reference retard tablet (preparation C). No accumulation of nifedipine in plasma occurred following multiple dosing.
FaceTube (2012)

The advances in automatic facial expression recognition make possible to mine and characterize large amounts of data, opening a wide research domain on behavioral understanding. In this paper, we leverage the use of a state-of-the-art facial expression recognition technology to characterize users of a popular type of online social video, conversational vlogs. First, we propose the use of several activity cues to characterize vloggers based on frame-by-frame estimates of facial expressions of emotion. Then, we present results for the task of automatically predicting vloggers' personality impressions using facial expressions and the Big-Five traits. Our results are promising, specially for the case of the Extraversion impression, and in addition our work poses interesting questions regarding the representation of multiple natural facial expressions occurring in conversational video.
Responsiveness and minimal clinically important difference for pain and disability instruments in low back pain patients (2006)

RMQ is suitable for measuring change in LBP only patients and both ODI and RMQ are suitable for leg pain patients irrespectively of patient entry point. The MCID is baseline score dependent but only in certain subpopulations. Relative change measured using the ODI and RMQ was not affected by baseline score when patients quantified an important improvement.
Efficient quasi-phase-matched frequency doubling of a high power, unpolarized fiber laser source (1998)

Summary form only given. The combination of sum frequency generation (SFG) and SHG processes has generated 590 mW of green light from a planar periodically poled lithium niobate (PPLN) waveguide, which, to the best of our knowledge, is the highest power ever reported from such a device. In this experiment, combining the SFG and SHG processes within the planar waveguide produced 35% more green power than would be obtained by frequency doubling the two infrared polarizations separately.
Detection ofABH Tissue Isoantigens by Immunoperoxidase Methods in Normal and Neoplastic Urothelium: Comparison with the Erythrocyte Adherence Method (1981)

The expression of the ABH blood group antigens (BGAg) by carcinomas of the urinary bladder at the time of initial biopsy heralds a relatively benign clinical course, whereas antigen deletion in histologically similar tumors is often predictive of tumor recurrences and invasion. The use of BGAg as a tumor marker in the clinical setting has been limited by difficulties in demonstrating BGAg in tissue sections with the erythrocyte adherence test, especially for antigen H. In this study, immunoperoxidase methods were used to detect BGAg in deparaffinized tissue sections of normal and malignant human urothelium, and the results were compared with those of the erythrocyte adherence test performed on adjacent sections. Results with the two methods were similar for antigens A and B; however, a novel lectin-antilectin immunoperoxidase method was clearly superior for detecting antigen H. The immunoperoxidase method significantly reduced false-positive test results for antigen deletion in normal urothelium and more accurately predicted the subsequent clinical course in patients having urinary bladder cancer.
Investigating two features of aesthetic perception in consumer photographic images: clutter and center (2011)

A key aspect of image effectiveness is how well the image visually communicates the main subject. In consumer images, two important features that impact viewer appreciation of the main subject are the amount of clutter and the main subject placement within the image. Two subjective experiments were conducted to assess the relationship between aesthetic and technical quality and perception of clutter and image center. For each experiment, 30 participants evaluated the same 70 images, on 0 to 100-point scales for aesthetic and technical quality. For the clutter experiment, participants also evaluated the images, on 0 to 100-point scales for amount of clutter and main subject emphasis. For the center experiment, participants pointed directly onto the image to mark the center of interest. Results indicate that aesthetic quality, technical quality, amount of clutter, and main subject emphasis are strongly correlated. Based on 95% confidence ellipses and mean-shift clustering, expert main subject maps are consistent with observer identification of main subject location. Further, the distribution of the observer identification of the center of interest is related to the object class (e.g., person, scenery). Additional features related to image composition can be used to explain clusters formed by patterns of mean ratings.
Cardiac Mechanical Assistance Beyond Balloon Pumping (1992)

Appropriate for both students and professional nurses, this book addresses all types of cardiac mechanical assist devices and their associated patient care. The book addresses every aspect of cardiac mechanical assistance; provides thorough coverage of the ventricular assist device team approach, including perfusionists and clinical bioengineers as well as critical care and cardiovascular nurses; and includes a section addressing the ethical issues surrounding ventricular assist devices and the psychosocial aspects affecting both the patient and the patient's family.
Reliability Improvement of Wire Bonds Subjected to Fatigue Stresses (1972)

The failure of wire bonds due to repeated flexure when semiconductor devices are operated in an on-off mode has been investigated. An accelerated fatigue testing apparatus was constructed and the major fatigue variables, aluminum alloy composition and bonding mechanism, were tested. The data showed Al-1% Mg wires to exhibit superior fatigue characteristics compared to Al-1% Cu or Al-1% Si and ultrasonic bonding to be better than thermo-compression bonding for fatigue resistance. Based on these results highly reliable devices were fabricated using Al-l% Mg wire with u1-trasonic bonding which withstood 1.2 × 105 power cycles with no failures.
Localization of Heparin Binding Activity in Recombinant Laminin G Domain (1997)

Basement membrane laminin (laminin-1) is a multidomain glycoprotein that interacts with itself, heparin and cells. The interaction with heparin/heparan sulfate proteglycans is thought to be important for the architectural formation of basement membranes and adhesion to cells. The major heparin binding site has been known to reside in the long arm globular domain (G domain). The G domain is in turn subdivided into five subdomains (G1-G5). In order to localize the heparin binding regions further, recombinant G domains (rG and rG5) were expressed in Sf9 insect cells using baculovirus expression vector. By the limited proteolysis of recombinant G domains followed by either heparin affinity HPLC or overlay with radiolabeled heparin, the relative affinity of each subdomain to heparin was assigned as G1>G2 = G4>G5>G3, such that G1 bound strongly and G3 not at all. Since the activity in G1-G3 is cryptic in intact laminin long arm [Sung, U., O'Rear, J. J. & Yurchenco, P. D. (1993) J. Cell Biol. 123, 1255-1268], the active heparin binding site of G domain appears to be located in G4 and proximal G5.
<title>Design Review Of Three Reflectance Scatterometers</title> (1983)

Design considerations for three scatterometers are presented. The first instrument, a total integrated scatter device, is currently used to make scatter measurements on flat reflectors in an optical finishing lab. The second scatterometer is a small research oriented system, nearly complete, which measures scattering intensity from relatively small diameter reflectors (a few inches) as a function of angle in the incident plane. The third system, which is still undergoing final design, also measures scattering intensity as a function of angle but will be able to do so in a nearly complete hemisphere in front of the sample. In addition, this third system will have variable angle of incidence capability and be able to measure scatter from any spot on flat reflectors up to 14 inches in diameter. Each of these systems is controlled by a small digital computer which, after initial system alignment, directs the measurement procedure, records data and analyzes results. This paper examines the problems associated with the mechanical motions of the systems, sample holding and orientation, system alignment, data compression and measurement of optical intensities that vary by as much as eight orders of magnitude. A short review of some applications for the data generated by these types of scatterometers is also given.
Finite element prediction of wave motion in structural waveguides (2005)

A method is presented by which the wavenumbers for a one-dimensional waveguide can be predicted from a finite element (FE) model. The method involves postprocessing a conventional, but low order, FE model, the mass and stiffness matrices of which are typically found using a conventional FE package. This is in contrast to the most popular previous waveguide/FE approach, sometimes termed the spectral finite element approach, which requires new spectral element matrices to be developed. In the approach described here, a section of the waveguide is modeled using conventional FE software and the dynamic stiffness matrix formed. A periodicity condition is applied, the wavenumbers following from the eigensolution of the resulting transfer matrix. The method is described, estimation of wavenumbers, energy, and group velocity discussed, and numerical examples presented. These concern wave propagation in a beam and a simply supported plate strip, for which analytical solutions exist, and the more complex case of a viscoelastic laminate, which involves postprocessing an ANSYS FE model. The method is seen to yield accurate results for the wavenumbers and group velocities of both propagating and evanescent waves.
Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes (1997)

We have previously identified three mammalian Sec1/Munc-18 homologues in adipocytes (Tellam, J. T., McIntosh, S., and James, D. E. (1995) J. Biol. Chem. 270, 5857-5863). These proteins are thought to modulate the interaction between vesicle membrane and target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and thus regulate intracellular vesicular transport. This study aimed to further characterize these Munc-18 isoforms and to define their potential role in the trafficking of GLUT-4 in adipocytes, a process reported to involve the vesicle membrane SNARE, VAMP-2. Using an in vitro binding assay with recombinant fusion proteins, we show that Munc-18a and Munc-18b bind to syntaxin-1A, -2, and -3, while Munc-18c binds only to syntaxin-2 and -4. The specific interaction between Munc-18c and syntaxin-4 is of interest because aside from syntaxin-1A, which is not expressed in adipocytes, syntaxin-4 is the only syntaxin that binds to VAMP-2. Using a three-way binding assay, it was shown that Munc-18c inhibits the binding of syntaxin-4 to VAMP-2. The subcellular distribution of syntaxin-4 and Munc-18c was almost identical, both being enriched in the plasma membrane, and both exhibiting an insulin-dependent movement out of an intracellular membrane fraction similar to that observed for GLUT-4. Munc-18b had a similar distribution to Munc-18c and so may also be involved in vesicle transport to the cell surface, whereas Munc-18a was undetectable by immunoblotting in adipocytes. Microinjection of a syntaxin-4 antibody into 3T3-L1 adipocytes blocked the insulin-dependent recruitment of GLUT-4 to the cell surface. These data suggest that syntaxin-4/Munc-18c/VAMP-2 may play a role in the docking/fusion of intracellular GLUT-4-containing vesicles with the cell surface in adipocytes.
Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury. (1987)

Reperfusion of ischemic myocardium has been postulated to result in a specific oxygen radical-mediated component of tissue injury. In a previous study we demonstrated improved recovery of ventricular function and metabolism when the superoxide radical scavenger superoxide dismutase was administered at the time of postischemic reflow. Studies in vitro, have suggested that superoxide toxicity might be mediated via the generation of more reactive hydroxyl radicals in an iron-catalyzed reaction. The present study was designed to test the hypothesis that myocardial reperfusion injury might be reduced by administration of the iron chelator deferoxamine at the time of reflow, most likely by preventing hydroxyl radical formation. Sixteen isolated Langendorff rabbit hearts, perfused within the bore of a superconducting magnet, were subjected to 30 min of normothermic (37 degrees C) total global ischemia followed by 45 min of reperfusion. At reflow eight treated hearts received a 10 ml bolus containing 50 mumol of deferoxamine followed by an infusion of 11 mumol/min for the first 15 min of reflow. The hearts were then perfused with standard perfusate for an additional 30 min. Eight untreated control hearts received a similar bolus of perfusate followed by 45 min of standard reperfusion. Serial 5 min 31P nuclear magnetic resonance spectra were recorded. Myocardial phosphocreatine (PCr) content fell to 5% to 7% of control during ischemia in both groups of hearts. Deferoxamine-treated hearts recovered 99 +/- 10% of control PCr content, while untreated hearts recovered 60 +/- 16% (p less than .05). Intracellular pH fell to 5.9 during ischemia in both groups, before showing more rapid and complete recovery in treated hearts (p less than .01). Recovery of developed pressure reached 70 +/- 6% of control in treated hearts compared with 35 +/- 10% in untreated hearts (p less than .05). Iron content of the perfusate was 7 microM, and by electron paramagnetic resonance spectroscopy was in the form of Fe3+-EDTA complexes. In the effluent of treated hearts iron was in the form of Fe3+-deferoxamine chelates. In summary, administration of the iron chelator deferoxamine at the time of postischemic reflow results in greater recovery of myocardial function and energy metabolism, which supports the hypothesis that iron plays an important role in the pathogenesis of reperfusion injury.
Liquid Metal Lithium Jet Experiment for IFMIF Target (2008)

The present paper reports experimental study on the liquid lithium (Li) target flow for the International Fusion Materials Irradiation Facility (IFMIF). Experiments on the Li flow were conducted with a liquid lithium circulation facility, with producing a 10 mm thick and 70 mm wide flat plane jet flow along a 70 mm wide horizontal straight channel at velocity of up to 15 m/s. The nozzle has a cross section of 1/2.5 scale of the IFMIF design. Free surface of the Li jet was photographed with using a CCD camera of wide dynamic range, and a stroboscopic light source. Variation of surface shape against velocity was revealed. In order to investigate the effect of the free surface wake generated at the nozzle corner on the surface shape, measurement of the thickness distribution and numerical calculation were attempted. Comparison between experimenral results, numerical calculation and a simplified model based on a ship wake showed that the surface wake generated at the nozzle corner had an insignificant effect on the surface shape of the D+ beam irradiation region in IFMIF.
Rh(0) colloids supported on TiO2: a highly active and pertinent tandem in neat water for the hydrogenation of aromatics (2011)

TiO2-supported Rh(0) nanoparticles were easily prepared in one step without calcination by a room temperature impregnation of the inorganic support with a prestabilized colloidal Rh(0) suspension. They are highly active and reusable catalysts for the hydrogenation of aromatics and chloroanisole derivatives in neat water with TOFs up to 33000 h−1. The comparison with the analogous silica system Rh@SiO2 was discussed showing higher catalytic selectivities and activities with Rh(0) colloids supported on TiO2.
Pharmacodynamic and pharmacokinetic comparison of two formulations of lorazepam and placebo (1988)

Abstract Nine healthy male volunteers took part in a comparison of the pharmacokinetic profiles and effects on psychomotor performance and memory following single dosing with an experimental sustained release (SR) and a conventional release (CR) formulation of lorazepam. There was evidence of a sustained release profile for the SR formulation which had a later t max (median 8 h) and significantly lower peak serum concentration (mean 12·1 ng ml −1 ) compared with CR lorazepam (2 h and 21.8 ng ml −1 respectively). The effect of SR lorazepam on pharmacodynamic variables occurred later and was less intense than with CR lorazepam. Good correlations were obtained between most of the pharmacodynamic parameters measured and the logarithm of the serum concentration for both formulations, with the exception of the choice reaction time test for SR lorazepam. However, both formulations produced a similar degree of impairment of 24h recall.
Editorial (1980)

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