gebhart/patrepeval huggingface dataset:
Characterization of Target mRNA Reduction Through <i>In Situ</i> RNA Hybridization in Multiple Organ Systems Following Systemic Antisense Treatment in Animals (2013)

Advances in the medicinal chemistry of antisense oligonucleotide drugs have been instrumental in achieving and optimizing antisense activity in cell types other than hepatocytes, the cell type that is most sensitive to antisense effects following systemic treatment. To broadly characterize the effects of antisense drugs on target messenger RNA (mRNA) levels in different organs and cell types in animals, we have developed a sensitive RNA in situ hybridization technique using the noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) as a surrogate target. We have used this technique to evaluate the effects of 2'-O-methoxy ethyl (MOE) and constrained ethyl bicyclic nucleic acid (cEt) gapmer antisense oligonucleotides (ASOs). ASO tissue distribution was also characterized using immunohistochemical techniques, and MALAT1 mRNA reductions were confirmed by quantitative real time-polymerase chain reaction. Our findings demonstrate that systemic antisense drug administration in both mice and non-human primates resulted in marked reductions in MALAT1 RNA in many tissues and cell types other than liver including kidney, muscle, lung, adipose, adrenal gland, and peripheral nerve tissue. As expected, ASOs with cEt chemistry were more efficacious than MOE ASO in all tissues examined.
Inactivation of tumours and viruses via effcient photoisomerisation (1989)

J. Davila, K. S. Gulliya and A. Harriman, J. Chem. Soc., Chem. Commun., 1989, 1215 DOI: 10.1039/C39890001215
Colors Change in China (1938)

Essay| February 01 1938 Colors Change in China Randall Gould Randall Gould Search for other works by this author on: This Site PubMed Google Scholar Current History (1935) 48 (2): 22–25. https://doi.org/10.1525/curh.1938.48.2.22 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Randall Gould; Colors Change in China. Current History 1 December 1935; 48 (2): 22–25. doi: https://doi.org/10.1525/curh.1938.48.2.22 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1938 by The Regents of the University of California1938 Article PDF first page preview Close Modal You do not currently have access to this content.
On‐line 2D‐LC‐ESI/MS/MS determination of rifaximin in rat serum (2009)

Abstract A highly sensitive and selective on‐line two‐dimensional reversed‐phase liquid chromatography/electrospray ionization–tandem mass spectrometry (2D‐LC‐ESI/MS/MS) method was developed and validated to determine rifaximin in rat serum by direct injection. The 2D‐LC‐ESI/MS/MS system consisted of a restricted access media column for trapping proteins as the first dimension and a Waters C 18 column as second dimension using 0.1% aqueous acetic acid:acetonitrile as mobile phase in a gradient elution mode. Rifampacin was used as an internal standard. The linear dynamic range was 0.5–10 ng/mL ( r 2 > 0.998). Acceptable precision and accuracy were obtained over the calibration range. The assay was successfully used in analysis of rat serum to support pharmacokinetic studies. Copyright © 2009 John Wiley & Sons, Ltd.
Effective VoIP call routing in WLAN and cellular integration (2005)

In cellular-WLAN integration, a dual-mode mobile station (MS) typically disables the WLAN module for power saving. A major problem is that for an incoming VoIP call (or data session), the MS will not be able to receive this call from the WLAN. It turns out that the call is directed to the cellular network. This letter proposes a simple push solution where an MS can accurately detect a VoIP call from paging signaling of the cellular network. Then the WLAN module of the MS is turned on and the VoIP call is connected to the MS through the relatively inexpensive WLAN.
Iodine(III)-mediated allylation of aromatic compounds and alcohols using allylmetal (group IVb) compounds. (1985)

The reaction of allylmetal (group IVb) compounds with aromatic compounds and iodosylbenzene in the presence of BF3-Et2O afforded the corresponding allylation products. Allylation of alcohols was also carried out to give allyl ethers. The activation of iodosylbenzene by the coordination of BF3-Et2O was assumed to be one of the most important factors for the reaction. The involvement of the reactive allyliodine (III) compounds in these reactions is discussed.
Authentication of Signaling in VoIP Applications (2005)

Session Initiation Protocol known as SIP is currently being preferred to H. 323 protocol due to its simple architecture. In Traditional SIP, security mechanisms are inadequate for assuring the identity of the end user based on cryptography. This is vulnerable in the sense that a third person, an impersonator, may easily duplicate one of the users engaged in the session. This can pose serious threats as it affects secrecy of the user. In order to reduce the threat posed by an eavesdropper, an authentication scheme is required. This paper proposes a scheme for authenticating the end users identities with the outbound proxy server in that domain with the help of the registrar server. The authentication scheme is based on end users public key infrastructure (PKI) certificate and strong one way hash function. The proposed scheme is implemented using JAVA and tested for its validity in a LAN environment. The delay overhead in providing authentication in the proposed scheme is found to be within the allowable limit as per IETF standard.
The duration of response to norgestimate and ethinyl estradiol in the treatment of acne vulgaris. (1999)

A triphasic combination of norgestimate and ethinyl estradiol lengthens the time interval to recurrence of acne lesions.
From Collagen to Gelatine (2007)

This chapter contains sections titled: Basic Chemical/Physical Principles and Technological Properties Basic Chemical/Physical Principles Chemical Composition and Molecular Structure of Collagen The Conditioning Process and its Effects on the Amino Acid Composition of Gelatine The Conditioning Process and its Effect on the Molecular weight Distribution of Gelatine Technologically Important Properties and Characteristics of Gelatine Gel Formation, Viscosity, and Texture Gel Strength/Bloom Value The Kinetics of Gel Formation The Rheology of a Gelatine Solution From Gelatine/Water to Complex Systems Surface Properties Amphoteric Behavior/Isoelectric Point Protective Colloid Function Adhesion Properties Basic Principles for Selecting a Suitable Type of Gelatine Chemically Modified Gelatines Manufacture of Gelatine: Theory and Practice The Raw Material “Ossein” Maceration Pressure Hydrolysis The Raw Material “Hide Split” The Raw Material Pigskin Conditioning Alkaline Pretreatment “Conditioning” for Type B Gelatine Acid Pretreatment for Type A Gelatine Traditional Extraction (Batch Process) Continuous Extraction Production of Fish and Fowl Gelatine Processing the Extracted Gelatine Filtration and Clarification Deionization Concentration Final Sterilization Drying Process for Granulated Gelatine Standardization and Packaging of Granulated Gelatine Manufacture of Leaf Gelatine Instant Gelatine Gelatine Hydrolysate Environmental Aspects of Gelatine Manufacture Quality Control and Certified Product Safety The Quality Assurance Process Raw Materials Production Standard Quality Tests on the Final Product Gel Strength (Bloom Value) Viscosity pH Water Content Color and Clarity Sulfur Dioxide and Peroxides Odor and Taste Inorganic Components Conductivity Microbiological Tests Special Chemical/Technological Tests Gelation Point, Melting Point, Gelation Time Rheology The Foam Test Isoelectric Point Molecular-Weight Distribution Nitrogen Determination using the Kjeldahl Method Determination of Gelatine Protein Hydroxyproline Special Tests for Photographic Applications Characterization of Photographic Properties Hardening Behavior Gold Number
Statistical ranking and combinatorial Hodge theory (2010)

We propose a technique that we call HodgeRank for ranking data that may be incomplete and imbalanced, characteristics common in modern datasets coming from e-commerce and internet applications. We are primarily interested in cardinal data based on scores or ratings though our methods also give specific insights on ordinal data. From raw ranking data, we construct pairwise rankings, represented as edge flows on an appropriate graph. Our statistical ranking method exploits the graph Helmholtzian, which is the graph theoretic analogue of the Helmholtz operator or vector Laplacian, in much the same way the graph Laplacian is an analogue of the Laplace operator or scalar Laplacian. We shall study the graph Helmholtzian using combinatorial Hodge theory, which provides a way to unravel ranking information from edge flows. In particular, we show that every edge flow representing pairwise ranking can be resolved into two orthogonal components, a gradient flow that represents the l 2-optimal global ranking and a divergence-free flow (cyclic) that measures the validity of the global ranking obtained—if this is large, then it indicates that the data does not have a good global ranking. This divergence-free flow can be further decomposed orthogonally into a curl flow (locally cyclic) and a harmonic flow (locally acyclic but globally cyclic); these provides information on whether inconsistency in the ranking data arises locally or globally. When applied to statistical ranking problems, Hodge decomposition sheds light on whether a given dataset may be globally ranked in a meaningful way or if the data is inherently inconsistent and thus could not have any reasonable global ranking; in the latter case it provides information on the nature of the inconsistencies. An obvious advantage over the NP-hardness of Kemeny optimization is that HodgeRank may be easily computed via a linear least squares regression. We also discuss connections with well-known ordinal ranking techniques such as Kemeny optimization and Borda count from social choice theory.
The ACCESS Study (2003)

Although the mechanisms by which angiotensin type 1 (AT1) receptor blockade affects cardiovascular morbidity and mortality are still unresolved, the present study shows that early neurohumoral inhibition has similar beneficial effects in cerebral and in myocardial ischemia. The fact that no cardiovascular or cerebrovascular event occurred as a result of hypotension is of significant clinical importance. When there is need for or no contraindication against early antihypertensive therapy, candesartan cilexetil is a safe therapeutic option according to the ACCESS results.
Cysteine-Scanning Mutagenesis of the Fifth External Loop of Serotonin Transporter (2004)

External loop 5 (EL5) of serotonin transporter was analyzed by mutating each of the residues from Thr-480 to Ala-511, one at a time, with cysteine. Cysteine was well-tolerated at most positions, although G485C, Y495C, and E508C had low transport activities. Replacement with cysteine rendered mutants G484C-P499C sensitive to partial or complete inactivation by [2-(trimethylammonium)ethyl] methanethiosulfonate and (2-sulfonatoethyl) methanethiosulfonate. Within this sensitive region, the rates of reaction varied by over 2 orders of magnitude. Rates of inactivation were not significantly affected by removal of Na(+) or by addition of cocaine or serotonin. These results suggest that modification of EL5 interferes with the transport process but is not sensitive to substrate and ion binding.
Survivable network system analysis: a case study (1999)

The Survivable Network Analysis method permits assessment of survivability at the architecture level. Steps include system mission and architecture definition, essential capability definition, compromisable capability definition, and survivability analysis of architectural soft-spots that are both essential and compromisable. The article summarizes application of the method to a subsystem of a large-scale, distributed health care system.
Application of Tin and Nanometer Tin in Allylation of Carbonyl Compounds in Tap Water (2002)

[reaction: see text] Nanometer tin-mediated allylation of aldehydes or ketones in distilled or tap water gave rise to corresponding homoallyl alcohol in high yield without any other assistance such as heat or supersonic or acidic media.
Selective enrichment of glycopeptides/phosphopeptides using porous titania microspheres (2010)

Titanium dioxide (TiO(2)) microspheres synthesized by sol-gel method showed high affinity to glycopeptides and were successfully used for simultaneous enrichment of glycopeptides and phosphopeptides.
Automatic mixed-signal behavioral model generation environment (2016)

Building the behavioral model for each circuit is an efficient approach for mixed-signal system verification. If an automatic model generator is available to generate the required behavioral model from the given circuit specifications or netlist, it is useful for designers to reduce the extra efforts. In this paper, two automation methodologies are proposed to build the behavioral models for speeding up mixed-signal system verification. For some popular circuit blocks, dedicated behavioral model generators are developed to obtain the corresponding models directly from the given specifications. For generic circuit blocks, a divide and conquer approach is proposed to extract the required behavioral models from the given circuit netlist. Instead of modeling the relationship between circuit inputs and outputs directly, dividing the circuit into several small building blocks can greatly reduce the model construction efforts without losing the generality for different circuits. As shown in the experimental results, the proposed model generation environment does generate the corresponding behavioral models automatically with good accuracy.
Bioelectrical Impedance Techniques in Medicine Part III: Impedance Imaging Third Section: Medical Applications (1996)

In several areas of clinical medicine, electrical impedance tomography could offer significant advantages over existing methods. These advantages have been supported by preliminary studies or by validation studies, which are described. The suggested applications are reviewed in this section. They mainly concern developments in impedance variations on brain, lung (neonatal, edema, emphysema), and heart; changes in blood volume, gastrointestinal system (gastric emptying, gastroesophageal reflux, pharyngeal transit time); pelvis (pelvis congestion); and thermal mapping in hyperthermia and breast (tissue characterization). The conductivity information at one frequency in a pixel is insufficient to take into account the very complex physiological mechanisms that underlie the observed impedance changes. To gain a better understanding of these mechanisms, research is currently being carried out on imaging of the imaginary part, parametric imaging, spectroscopic imaging, and 3D imaging, which are developed at the end of this section.
Control of genes for conjugative transfer of plasmids and other mobile elements (1998)

Conjugative transfer is a primary means of spread of mobile genetic elements (plasmids and transposons) between bacteria.It leads to the dissemination and evolution of the genes (such as those conferring resistance to antibiotics) which are carried by the plasmid. Expression of the plasmid genes needed for conjugative transfer is tightly regulated so as to minimise the burden on the host. For plasmids such as those belonging to the IncP group this results in downregulation of the transfer genes once all bacteria have a functional conjugative apparatus. For F-like plasmids (apart from F itself which is a derepressed mutant) tight control results in very few bacteria having a conjugative apparatus. Chance encounters between the rare transfer-proficient bacteria and a potential recipient initiate a cascade of transfer which can continue until all potential recipients have acquired the plasmid. Other systems express their transfer genes in response to specific stimuli. For the pheromone-responsive plasmids of Enterococcus it is small peptide signals from potential recipients which trigger the conjugative transfer genes. For the Ti plasmids of Agrobacterium it is the presence of wounded plants which are susceptible to infection which stimulates T-DNA transfer to plants. Transfer and integration of T-DNA induces production of opines which the plasmid-positive bacteria can utilise. They multiply and when they reach an appropriate density their plasmid transfer system is switched on to allow transfer of the Ti plasmid to other bacteria. Finally some conjugative transfer systems are induced by the antibiotics to which the elements confer resistance. Understanding these control circuits may help to modify management of microbial communities where plasmid transfer is either desirable or undesirable. z 1998 Published by Elsevier Science B.V.
Aportes a una pedagogía (constructivista) de la motricidad. Un estudio experimental sobre los efectos del juego y el ejercicio en el aprendizaje de habilidades motoras y actitudes en la infancia. Primera parte (2005)

Este estudio analiza, en la perspectiva del constructivismo social, el efecto de diferentes programas de enseñanza de la educación física, sobre la adquisición, retención y transferencia de una habilidad motora y sobre las representaciones de valor que los niños /as asignan a la práctica de la educación física.
The Use of AFP-Complexes to Induce Apoptosis in Cancer Cells (2008)

An anticancer magic bullet should have both efficacy and specificity parts. We have used an effective Apop- tosis I nducer t o t rigger t he apoptosis. A lpha-fetoprotein w as us ed t o de liver A poptosis I nducers s pecifically t o cancer cells. The AFP-AI complex inhibited tumor growth in mice, enlarged mice life survival and has shown a 50% response in patients with metastatic colorectal cancer.
NEW TECHNIQUE FOR METAL COATING OF SUBMICRON PARTICLES. (1968)

Individual monitoring regulations in Switzerland are based on the ICRP60 recommendations. The annual limit of 20 mSv for the effective dose applies to the sum of external and internal radiation. External radiation is monitored monthly or quarterly with TLD, DIS or CR-39 dosemeters by 10 approved external dosimetry services and reported as Hp(10) and Hp(0.07). Internal monitoring is done in two steps. At the workplace, simple screening measurements are done frequently in order to recognise a possible incorporation. If a nuclide dependent activity threshold is exceeded then one of the seven approved dosimetry services for internal radiation does an incorporation measurement to assess the committed effective dose E50. The dosimetry services report all the measured or assessed dose values to the employer and to the National Dose Registry. The employer records the annually accumulated dose values into the individual dose certificate of the occupationally exposed person, both the external dose Hp(10) and the internal dose E50 as well as the total effective dose E=Hp(10)+E50. Based on the national dose registry an annual report on the dosimetry in Switzerland is published which contains the statistics for the total effective dose, as well as separate statistics for external and internal exposure.
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. (2003)

The androgen-regulated enzyme fatty acid synthase (FAS), required for de novo lipogenesis, is overexpressed in several cancers including prostate carcinoma and has been associated with aggressive disease. FAS expression was assessed in 81 prostate carcinomas, both by immunohistochemistry in tissue microarrays and by Affymetrix Hu95Av2 oligonucleotide arrays. Both FAS mRNA and protein were significantly overexpressed in prostate carcinomas compared with the corresponding normal tissue. FAS mRNA and protein expression increased substantially from normal to prostatic intraepithelial neoplasia, to low grade, to high grade, and to androgen-independent bone metastases. A significant correlation between FAS mRNA and protein expression was found in two thirds of the cases. In 17% of the cases, FAS protein levels were high despite low mRNA levels, and these tumors exhibited a distinct molecular signature when compared with tumors that did not express FAS protein. Whereas the latter group of tumors expressed some proapoptotic genes, tumors with high FAS levels overexpressed, among other genes, its transcriptional regulator, steroid regulator binding protein, and apolipoprotein E. These data demonstrate (1) the consistent overexpression of FAS in prostate carcinoma compared with the adjacent normal tissue, (2) a strong association between FAS and prostate tumor initiation and progression, (3) the highest FAS expression occurring in androgen-independent bone metastases, (4) the transcriptional and posttranscriptional regulation of FAS in the majority and in a subset of prostate cancers, respectively, and (5) most importantly, the identification by FAS expression of prostate tumors with unique molecular signatures and potentially diverse biologic behavior.
SLA-Aware Routing Strategy for Multi-Tenant Software-Defined Networks (2020)

A crucial requirement for the network service provider is to satisfy the Service Level Agreements (SLA) that it has made with its customers. Coexisting network tenants may have agreed different SLAs, and thus, the service provider must be able to provide QoS differentiation in order to meet his contractual commitments. Current one-size-fits-all routing models are not appropriate for all network tenants if their individual SLA requirements are to be efficiently met. We propose a SDN-based multi-cost routing approach which allocates network resources based on a portfolio of tenant SLA, which achieves the goal of accommodating multiple tenants, given their SLAs. This routing approach allocates routes based on both the hop count and the probability of link failure. Experimental evaluation demonstrates that the assignment of network paths to tenants is prioritised according to the SLA class of the tenant. Differentiation between tenants who have different SLAs is achieved. Finally, we demonstrate how the routing model operates and how it impacts upon the provision of different levels of service.
Pyroelectric properties of PLT thin films (1995)

Abstract Pyroelectric properties of PLT thin films prepared by MOD method are characterized. Dynamic pyroelectric responses of the films measured with Chynoweth method are presented. Pyroelectric responses of point and quadruple pyroelectric detectors using PLT20 thin films are measured. One-dimensional heat conduction model is used to analyze the properties of the detectors. requirements to the PLT films used for pyroelectric detectors are proposed.