gebhart/patrepeval huggingface dataset:
Challenges and Controversies in Autoantibodies Associated with Systemic Rheumatic Diseases (2007)

Since the first identification of self-reactive antibodies in systemic lupus erythematosus and other systemic autoimmune rheumatic diseases, many autoantibodies have been identified as useful probes in molecular and cell biology and as diagnostic and prognostic biomarkers in clinical immunology. Among the autoantigens, double-stranded desoxoribonucleic acid (dsDNA), the Smith antigen (Sm), ribonucleoproteins (RNP), Scl-70 (topoisomerase I), proliferating cell nuclear antigen (PCNA), and others were described as serologic hallmarks in the diagnosis of systemic autoimmune rheumatic diseases. Despite these advances in identifying autoantibody markers, a number of challenges and controversies persist concerning their origin, clinical usefulness and relevance. These include the association between anti-ribosomal P antibodies and clinical features in systemic lupus erythematosus, the disease specificity of several autoantibodies (i.e. chromatin, Jo-1, alpha-fodrin, topo I and CENP), the relationship between the SS-A/Ro52 and SS-A/Ro60 autoantibody system(s) and the detection of anti-RNP/Sm and anti-fibrillarin antibodies. Keywords: Autoantibody, SLE, dsDNA, systemic rheumatic disease
TUNING CONTROLLERS FOR SET POINT CHANGES. (1970)

Abstract : Optimum settings for disturbance changes are not optimum for changes in set point; and in certain applications set point changes are rather common. It is the purpose of this article to develop controller tuning relationships based on the minimization of error integrals for set point changes. It will also be shown how these relationships may be used to tune both conventional and direct digital control loops. (Author)
Recursive position estimation in sensor networks (2005)

Recursive hierarchy provides a framework for extending position estimation throughout a sensor network. Given imprecise ranging and inter-node communication, nodes scattered throughout a large volume can estimate their physical locations from a small set of reference nodes using only local information. System coverage increases iteratively, as nodes with newly estimated positions join the reference set, capitalizing on the massive scale of sensor networks. The system frames position estimation as a geometric problem solvable through common nonlinear regression techniques and develops methods for gauging the reliability of position estimates. This provides a flexible framework that can use and enhance a variety of technologies and protocols to produce fine-grained position estimates. A specific model provides a simulation environment showing that over 90% of position estimates are correct to within 3% of the ranging distance with only 5% of the system in the initial reference set.
Attenuated <i>Toxoplasma gondii</i> Stimulates Immunity to Pancreatic Cancer by Manipulation of Myeloid Cell Populations (2015)

Suppressive myeloid cells represent a significant barrier to the generation of productive antitumor immune responses to many solid tumors. Eliminating or reprogramming suppressive myeloid cells to abrogate tumor-associated immune suppression is a promising therapeutic approach. We asked whether treatment of established aggressive disseminated pancreatic cancer with the immunotherapeutic attenuated Toxoplasma gondii vaccine strain CPS would trigger tumor-associated myeloid cells to generate therapeutic antitumor immune responses. CPS treatment significantly decreased tumor-associated macrophages and markedly increased dendritic cell infiltration of the pancreatic tumor microenvironment. Tumor-resident macrophages and dendritic cells, particularly cells actively invaded by CPS, increased expression of costimulatory molecules CD80 and CD86 and concomitantly boosted their production of IL12. CPS treatment increased CD4(+) and CD8(+) T-cell infiltration into the tumor microenvironment, activated tumor-resident T cells, and increased IFNγ production by T-cell populations. CPS treatment provided a significant therapeutic benefit in pancreatic tumor-bearing mice. This therapeutic benefit depended on IL12 and IFNγ production, MyD88 signaling, and CD8(+) T-cell populations. Although CD4(+) T cells exhibited activated effector phenotypes and produced IFNγ, CD4(+) T cells as well as natural killer cells were not required for the therapeutic benefit. In addition, CD8(+) T cells isolated from CPS-treated tumor-bearing mice produced IFNγ after re-exposure to pancreatic tumor antigen, suggesting this immunotherapeutic treatment stimulated tumor cell antigen-specific CD8(+) T-cell responses. This work highlights the potency and immunotherapeutic efficacy of CPS treatment and demonstrates the significance of targeting tumor-associated myeloid cells as a mechanism to stimulate more effective immunity to pancreatic cancer.
Innovative through-Si 3D lithography for ultimate self-aligned planar Double-Gate and Gate-All-Around nanowire transistors (2013)

Session 15: Nanowires (#15.1)
Vaccine-Elicited CD8 <sup>+</sup> T Cells Protect against Respiratory Syncytial Virus Strain A2-Line19F-Induced Pathogenesis in BALB/c Mice (2012)

CD8(+) T cells may contribute to vaccines for respiratory syncytial virus (RSV). Compared to CD8(+) T cells responding to RSV infection, vaccine-elicited anti-RSV CD8(+) T cells are less well defined. We used a peptide vaccine to test the hypothesis that vaccine-elicited RSV-specific CD8(+) T cells are protective against RSV pathogenesis. BALB/c mice were treated with a mixture (previously termed TriVax) of an M2(82-90) peptide representing an immunodominant CD8 epitope, the Toll-like receptor (TLR) agonist poly(I·C), and a costimulatory anti-CD40 antibody. TriVax vaccination induced potent effector anti-RSV CD8(+) cytotoxic T lymphocytes (CTL). Mice were challenged with RSV strain A2-line19F, a model of RSV pathogenesis leading to airway mucin expression. Mice were protected against RSV infection and against RSV-induced airway mucin expression and cellular lung inflammation when challenged 6 days after vaccination. Compared to A2-line19F infection alone, TriVax vaccination followed by challenge resulted in effector CD8(+) T cells with greater cytokine expression and the more rapid appearance of RSV-specific CD8(+) T cells in the lung. When challenged 42 days after TriVax vaccination, memory CD8(+) T cells were elicited with RSV-specific tetramer responses equivalent to TriVax-induced effector CD8(+) T cells. These memory CD8(+) T cells had lower cytokine expression than effector CD8(+) T cells, and protection against A2-line19F was partial during the memory phase. We found that vaccine-elicited effector anti-RSV CD8(+) T cells protected mice against RSV infection and pathogenesis, and waning protection correlated with reduced CD8(+) T cell cytokine expression.
Spectral Clustering and Biclustering: Learning Large Graphs and Contingency Tables (2013)

Explores regular structures in graphs and contingency tables by spectral theory and statistical methods This book bridges the gap between graph theory and statistics by giving answers to the demanding questions which arise when statisticians are confronted with large weighted graphs or rectangular arrays. Classical and modern statistical methods applicable to biological, social, communication networks, or microarrays are presented together with the theoretical background and proofs. This book is suitable for a one-semester course for graduate students in data mining, mult
The Role of Cystine Knots in Collagen Folding and Stability, Part II. Conformational Properties of (Pro‐Hyp‐Gly)<sub><i>n</i></sub> Model Trimers with N‐ and C‐Terminal Collagen Type III Cystine Knots (2003)

In mature collagen type III the homotrimer is C-terminally cross-linked by an interchain cystine knot consisting of three disulfide bridges of unknown connectivity. This cystine knot with two adjacent cysteine residues on each of the three alpha chains has recently been used for the synthesis and expression of model homotrimers. To investigate the origin of correct interchain cysteine pairings, (Pro-Hyp-Gly)(n) peptides of increasing triplet number and containing the biscysteinyl sequence C- and N-terminally were synthesised. The possibilities were that this origin may be thermodynamically coupled to the formation of the collagen triple helix as happens in the oxidative folding of proteins, or it could represent a post-folding event. Only with five triplets, which is known to represent the minimum number for self-association of collagenous peptides into a triple helix, air-oxidation produces the homotrimer in good yields (70 %), the rest being intrachain oxidised monomers. Increasing the number of triplets has no effect on yield suggesting the formation of kinetically trapped intermediates, which are not reshuffled by the glutathione redox buffer. N-terminal incorporation of the cystine knot is significantly less efficient in the homotrimerisation step and also in terms of triple-helix stabilisation. Compared to an artificial C-terminal cystine knot consisting of two interchain disulfide bridges, the collagen type III cystine knot produces collagenous homotrimers of remarkably high thermostability, although the concentration-independent refolding rates are not affected by the type of disulfide bridging. Since the natural cystine knot allows ready access to homotrimeric collagenous peptides of significantly enhanced triple-helix thermostability it may well represent a promising approach for the preparation of collagen-like innovative biomaterials. Conversely, the more laborious regioselectively formed artificial cystine knot still represents the only synthetic strategy for heterotrimeric collagenous peptides.
Powered to play: A mixed reality game for people driving powered chairs (2014)

People who drive powered chairs such as scooters and wheelchairs are often excluded from physical play activities because of their mobility differences. Video games that capture body motion such as sports or dancing games also often exclude people with limited mobility. However, combining the advantages of digital environments such as flexible virtualized scenes and controls with the physical advantages of having a powered chair may offer powered mobility device users social entertainment opportunities that are not otherwise available. Powered to Play is developed as a mixed reality capture-the-flag game for people who drive powered mobility devices. It uses a GPS-enabled mobile phone to display and interact with users in combination with the physical environment. Evaluation of the game was carried out with thirteen mobility devices users during two gameplay sessions located in different physical settings. Our findings show that a mixed reality game enabled by mobile phone interfaces in a large outdoor area was usable, feasible, and generally well-received by users.
RNA association and nucleocytoplasmic shuttling by ataxin-1 (2004)

Spinocerebellar ataxia type 1 (SCA1) is a dominant neurodegenerative disease caused by the expression of mutant ataxin-1 containing an expanded polyglutamine tract. Ataxin-1 is a nuclear protein that localizes to punctate inclusions similar to neuronal nuclear inclusions seen in many polyglutamine expansion disease proteins. We demonstrate that ataxin-1 localization to inclusions and inclusion dynamics within the nucleus are RNA and transcription dependent, but not dependent on the polyglutamine tract. Ataxin-1 nuclear inclusions are distinct from other described nuclear bodies but recruit the mRNA export factor, TAP/NXF1, in a manner that is enhanced by cell heat shock. By FRAP protein dynamic studies in live cells, we found that wild-type, but not mutant, ataxin-1 was capable of nuclear export. These results suggest that the normal role of ataxin-1 may be in RNA processing, perhaps nuclear RNA export. Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease.
Feedback control of arm movements using Neuro-Muscular Electrical Stimulation (NMES) combined with a lockable, passive exoskeleton for gravity compensation (2014)

Within the European project MUNDUS, an assistive framework was developed for the support of arm and hand functions during daily life activities in severely impaired people. This contribution aims at designing a feedback control system for Neuro-Muscular Electrical Stimulation (NMES) to enable reaching functions in people with no residual voluntary control of the arm and shoulder due to high level spinal cord injury. NMES is applied to the deltoids and the biceps muscles and integrated with a three degrees of freedom (DoFs) passive exoskeleton, which partially compensates gravitational forces and allows to lock each DOF. The user is able to choose the target hand position and to trigger actions using an eyetracker system. The target position is selected by using the eyetracker and determined by a marker-based tracking system using Microsoft Kinect. A central controller, i.e., a finite state machine, issues a sequence of basic movement commands to the real-time arm controller. The NMES control algorithm sequentially controls each joint angle while locking the other DoFs. Daily activities, such as drinking, brushing hair, pushing an alarm button, etc., can be supported by the system. The robust and easily tunable control approach was evaluated with five healthy subjects during a drinking task. Subjects were asked to remain passive and to allow NMES to induce the movements. In all of them, the controller was able to perform the task, and a mean hand positioning error of less than five centimeters was achieved. The average total time duration for moving the hand from a rest position to a drinking cup, for moving the cup to the mouth and back, and for finally returning the arm to the rest position was 71 s.
Report of the Secretary-Treasurer for the Year 1937-1938 (1938)

Journal Article Report of the Secretary-Treasurer for the Year 1937–1938 Get access C. S. Paine C. S. Paine Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 25, Issue 2, September 1938, Pages 245–250, https://doi.org/10.1093/jahist/25.2.245 Published: 01 September 1938
Synthesis of Chroman Derivatives by the Ring Expansion Reaction of Spirodienones, and an Assessment of Their Plant Growth Inhibition. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy: Impact of Intravitreal Anti-VEGF Treatment (2012)

Although cellular and molecular bases of proliferative diabetic retinopathy are only partially understood, it is evident that this complication of diabetes is characterized by the formation of new vessels inside the retina showing abnormal architecture and permeability. This process, if not controlled by selective laser photocoagulation, leads to irreversible retinal damages and loss of vision. Angiogenesis, that is, the condition characterized by the growth of new blood vessels originated from preexisting ones, was shown to have a major role in the pathogenesis of proliferative retinopathy and, as a consequence, intravitreal antiangiogenic injection was suggested as a feasible treatment for this disease. Here, we describe the different antiangiogenic approaches used to treat this disease along with the respective advantages and limitations when compared to laser treatment. Altogether, even though further and longer studies are still needed to clarify the best possible therapeutic protocol, the antiangiogenic treatment will reasonably have a future role in the therapy and prevention of proliferative diabetic retinopathy.
New local gazetteers from China (2010)

Purpose New (post‐1949) Chinese local gazetteers are one of the major primary resources for contemporary China Studies in the field of history, social sciences, humanities and sciences. Major research libraries in North America have collected them; however, the research value of this series of publications has not yet fully explored. This paper aims at examining how new local gazetteers have been compiled, the scope of their content and research value, and how scholars have used them. Design/methodology/approach The paper explores the scope and importance of the new Chinese local gazetteers collection through reviewing relevant regulations, policies and guidelines regarding compilation of the new local gazetteers, and randomly examining over 30 provincial, city and county gazetteers. Findings The paper provides a detailed account of publishing history of this collection; rich and unique research information available; and approaches to collection development, including utilizing digitized gazetteers by Chinese governments. Originality/value The paper explores the development of new Chinese local gazetteers in a more systematic way and adds to the current literature on the unique research value this collection has to offer.
LEVANTAMENTO E AVALIAÇÃO DA SAÚDE E RISCOS OCUPACIONAIS EM EMPREENDIMENTO DO SETOR DE PANIFICAÇÃO - ESTUDO DE CASO (2018)

Com o aumento dos acidentes de trabalho no setor de panificacao e confeitaria, torna-se essencial a adocao de medidas preventivas e protetivas nas empresas visando a seguranca do trabalhador. Neste sentido, o objetivo deste estudo foi de avaliar os riscos ocupacionais o qual funcionarios estejam submentidos ao longo da jornada de trabalho de 8 horas-dia em uma  industria de bolachas em Santiago, Rio Grande do Sul. Foram realizarados medicoes dos indices de exposicao ao ruido (batedeira e amassadeira industrial) e ao calor (forno eletrico industrial)  no setor de producao .  O levantamento de dados foi feito de forma quantitativa e qualitativa, conforme as Normas Regulamentadoras (NRs) do Ministerio do Trabalho.  A partir do mapeamento dos riscos pode-se sugerir medidas de mitigacao dos riscos identificados.  Todas as medicoes estao dentro dos limites de tolerância estabelecidos pelas NRs, dispensando medidas de controle. Tambem foram identificados riscos de esmagamento (batedeira planetaria) e queimadura (forno eletrico). No setor administrativo e de producao foram identificados riscos ergonomicos. Por fim, foram recomendados pequenos ajustes pontuais no que tange ao treinamento e observância das normas de seguranca pelos funcionarios como estrategia de mitigar os riscos de acidentes de trabalho e aprimorar o servico de seguranca de trabalho desenvolvido pelo empreendimento.
Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background (2003)

To understand the role of the calcium-sensing receptor (CasR) in the skeleton, we used a genetic approach to ablate parathyroid glands and remove the confounding effects of elevated parathyroid hormone (PTH) in CasR-deficient mice. CasR deficiency was transferred onto the glial cells missing 2–deficient (Gcm2-deficient) background by intercrossing CasR- and Gcm2-deficient mice. Superimposed Gcm2 deficiency rescued the perinatal lethality in CasR-deficient mice in association with ablation of the parathyroid glands and correction of the severe hyperparathyroidism. In addition, the double homozygous CasR- and Gcm2-deficient mice demonstrated healing of the abnormal mineralization of cartilage and bone associated with CasR deficiency, indicating that rickets and osteomalacia in CasR-deficient mice are not due to an independent function of CasR in bone and cartilage but to the effect of severe hyperparathyroidism in the neonate. Analysis of the skeleton of 6-week-old homozygous CasR- and Gcm2-deficient mice also failed to identify any essential, nonredundant role for CasR in regulating chondrogenesis or osteogenesis, but further studies are needed to establish the function of CasR in the skeleton. In contrast, concomitant Gcm2 and CasR deficiency failed to rescue the hypocalciuria in CasR-deficient mice, consistent with direct regulation of urinary calcium excretion by CasR in the kidney. Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR.
Traversing Knowledge Graphs in Vector Space (2015)

Path queries on a knowledge graph can be used to answer compositional questions such as "What languages are spoken by people living in Lisbon?". However, knowledge graphs often have missing facts (edges) which disrupts path queries. Recent models for knowledge base completion impute missing facts by embedding knowledge graphs in vector spaces. We show that these models can be recursively applied to answer path queries, but that they suffer from cascading errors. This motivates a new "compositional" training objective, which dramatically improves all models' ability to answer path queries, in some cases more than doubling accuracy. On a standard knowledge base completion task, we also demonstrate that compositional training acts as a novel form of structural regularization, reliably improving performance across all base models (reducing errors by up to 43%) and achieving new state-of-the-art results.
Gram-scale free radical polymerization of an azaborine vinyl monomer (2017)

The gram-scale polymerization of a novel azaborine vinyl monomer is reported. We describe an efficient and high-yielding synthesis of B-vinyl-2,1-borazanaphthalene. Homopolymers and co-polymers with 2-vinylnaphthalene are characterized by heteronuclear NMR and absorbance spectroscopy.
Heterodyne holographic nanometer alignment for a half-micron wafer stepper (1990)

Heterodyne Holographic Nanometer Alignment system has been applied in a halfmicron wafer stepperfor mass production usage to achieve the overlay accuracy within 0. 1 micron. Resultant overlay accuracy was successfully obtained within 63nm/3sigma for die by die alignment sequence and 8Onm/3sigma for multisampling global alignment sequence. A throughput of 50 6inch wafers per one hour was achieved for multi global alignment sequence. Alignment error budget was estimated for this alignment system and it was confirmed that total overlay accuracy of all processed wafers within 0. 1 micron for halfmicron photolithography was realized using Heterodyne Holographic Nanometer Alignmnent method. In addition onaxis TTR (Through The Reticle) alignment system was investigated for a future subhalf micron wafer stepper and the resul tant overlay accuracy was improved to be 55nm/3sigma. 1 .
A CoMP soft handover scheme for LTE systems in high speed railway (2012)

With the development of high-speed railway and public growing demand on data traffic, people pay much more attention to provide high data rate and high reliable services under high mobility circumstance. Due to the higher data rate and lower system latency, long-term evolution (LTE) has been chosen as the next generation's evolution of railway mobile communication system by the International Union of Railways. However, there are still many problems to be solved in the high mobility applications of LTE, especially the higher handover failure probability, which seriously degrades the reliability of railway communication. This article proposes an optimized handover scheme, in which the coordinated multiple point transmission technology and dual vehicle station coordination mechanism are applied to improve the traditional hard handover performance of LTE. The scheme enables the high speed train to receive signals from both adjacent base stations and obtain diversity gain when it moves through the overlapping areas, so it improves the quality of the received signal and provides reliable communication between train and ground eNodeBs. Numerical analysis and simulation results show that the proposed scheme can decrease the outage probability remarkably during handover and guarantee the reliability of train to ground communication.