gebhart/patrepeval huggingface dataset:
PENGARUH CORPORATE GOVERNANCE (CG) TERHADAP KUALITAS LABA DENGAN MANAJEMEN LABA SEBAGAI VARIABEL INTERVENING (STUDI PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI BARANG KONSUMSI DI BURSA EFEK INDONESIA TAHUN 2017-2020) (2023)

Penelitian ini bertujuan untuk memberikan bukti empiris pengaruh Corporate Governanceterhadap Kualitas Laba dengan Manajemen Laba sebagai Variabel Intervening pada perusahaan Manufaktur Sektor Industri Barang Konsumsi di Bursa Efek Indonesia (BEI) tahun 2017-2020. Sampel dalam penelitian ini adalah perusahaan Manufaktur Sektor Industri Barang Konsumsi yang terdaftar di Bursa Efek Indonesia (BEI) untuk tahun 2022 yang menerbitkan laporan tahunan periode 2017-2020. Proses pemilihan sampel dalam penelitian ini menggunakan metode Proportionate stratified random sampling. Analisis data yang digunakan dalam penelitian ini adalah path analysis menggunakan alat analisis SmartPLS 3.0. Hasil penelitian menunjukkan bahwa Corporate Governance berpengaruh terhadap kualitas laba. Corporate Governance berpengaruh terhadap manajemen laba. Manajemen laba tidak berpengaruh secara negatif terhadap kualitas laba. Corporate Governance terhadap kualitas laba dengan manajemen laba sebagai variabel Intervening tidak berpengaruh.
Complete sequence of human cardiac α‐myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences (1991)

We have obtained the 5820 nucleotide sequence encoding all 1939 amino acids of the human cardiac alpha-myosin heavy chain (alpha-MHC), as established by dideoxy sequencing of cloned cDNA, genomic DNA and polymerase chain reaction (PCR) amplification products. This sequence represents overlapping fragments of the entire coding sequence. Amino acid sequence comparison of the human cardiac alpha-MHC with the published human cardiac beta-MHC have demonstrated that there are, at least, 7 isoform-specific divergent regions, including functionally important binding protein-related sites such as ATP, actin and myosin light chain. It has been reported that in the rat, there are 8 isoform-specific divergent regions. The 7th divergent area (residue area 1633-1657, which is thought to mediate thick filament formation) in the light meromyosin region in the rat is not apparent in the human. The amino acid compositions of cardiac alpha- and beta-MHCs in the human and the rat, and human embryonic skeletal muscle and chicken gizzard smooth muscles were compared. Amino acid sequences in cardiac alpha- and beta-MHCs in the human and the rat are well conserved. In the head portion, the amino acid composition divergence of human cardiac alpha-MHC is ranked between rat cardiac alpha-MHC and human cardiac beta- or rat cardiac beta-MHC; human skeletal muscle MHC is the most divergent of the myosin isoform examined. These data predict that human cardiac alpha-MHC may have undergone evolutionary changes toward obtaining the biochemical and physiological properties of cardiac beta-MHC.
Q-decomposition for reinforcement learning agents (2003)

The paper explores a very simple agent design method called Q-decomposition, wherein a complex agent is built from simpler subagents. Each subagent has its own reward function and runs its own reinforcement learning process. It supplies to a central arbitrator the Q-values (according to its own reward function) for each possible action. The arbitrator selects an action maximizing the sum of Q-values from all the subagents. This approach has advantages over designs in which subagents recommend actions. It also has the property that if each subagent runs the Sarsa reinforcement learning algorithm to learn its local Q-function, then a globally optimal policy is achieved. (On the other hand, local Q-learning leads to globally suboptimal behavior.) In some cases, this form of agent decomposition allows the local Q-functions to be expressed by much-reduced state and action spaces. These results are illustrated in two domains that require effective coordination of behaviors.
Anti-<i>Trypanosoma cruzi</i>effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins (2007)

Cyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported the in vitro anti-Trypanosoma cruzi activity of H-7-94 and F-7-62 non-immunosuppressive CsA analogues. In this work, we continue the study of the parasiticidal effect of H-7-94 and F-7-62 CsA analogues in vitro and in vivo and we analyse 3 new CsA derivatives: MeIle-4-CsA (NIM 811), MeVal-4-CsA (MeVal-4) and D-MeAla-3-EtVal-4-CsA, (EtVal-4). The most efficient anti-T. cruzi effect was observed with H-7-94, F-7-62 and MeVal-4 CsA analogues evidenced as inhibition of epimastigote proliferation, trypomastigote penetration, intracellular amastigote development and in vivo T. cruzi infection. This trypanocidal activity could be due to inhibition of the peptidyl prolyl cis-trans isomerase activity on the T. cruzi recombinant cyclophilins tested. Furthermore, CsA and F-7-62 derivative inhibited the efflux of rhodamine 123 from T. cruzi epimastigotes, suggesting an interference with a P-glycoprotein activity. Moreover, H-7-94 and F-7-62 CsA analogues were not toxic as shown by cell viability and by aminopyrine-N-demethylase activity on mammalian cells. Our results show that H-7-94, F-7-62 and MeVal-4 CsA analogues expressed the highest inhibiting effects on T. cruzi, being promissory parasiticidal drugs worthy of further studies.
Separation of the Metals in Precious Lead by Vacuum Distillation Process (2014)

Availability of vacuum distillation for the separation of lead, silver, copper, bismuth and stibium in precious lead was studied by both theoretical analysis and experiments. Experimental results demonstrate that the evaporation rate of Pb and Bi is close to 100% when the temperature is above 800℃, holding time is more than 2 h and system pressure is 10 to 20 Pa. Meanwhile, the evaporation rate of Ag and Sb increase with the temperature and holding time being increased. When the temperature is 850℃and holding time is 2 h, the contents of Pb, Ag, Cu, Bi and Sb in the residue are 0.21%, 45.31%, 13.24%, 0.0001% and 33.6%, respectively. Besides, the contents of Pb, Ag, Cu, Bi and Sb in the volatile are 46.15%, 0.236%, 0.022%, 8.87% and 35.4%, respectively.
Synthesis of new arylidencycloalkylpyrazoles of potential biological interest (2003)

Abstract Indazoles and pyrazoles are known to be pharmaceutically relevant molecules. In particular their application as both analgesic and antitumoral drugs has been reported. In order to investigate the properties of compounds belonging to these families, we have synthesised new cycloalkylpyrazoles bearing an arylidene group on the cycloalkyl ring, with the aim of modifying the biological profile of these molecules.
Stratified adaptive cluster sampling (1991)

Stratified adaptive cluster sampling refers to designs in which, following an initial stratified sample, additional units are added to the sample from the neighbourhood of any selected unit with an observed value that satisfies a condition of interest. If any of the added units in turn satisfies the condition, still more units are added to the sample. Estimation of the population mean or total with the stratified adaptive cluster designs is complicated by the possibility that a selection in one stratum may result in the addition of units from other strata to the sample, so that observations in separate strata are not independent. Since conventional estimators such as the stratified sample mean are biased with the adaptive designs of this paper, several types of estimators are developed which are unbiased for the population mean or total with stratified adaptive cluster sampling.
Structure and optical properties of Ge-Si ordered superlattices (1987)

We report the synthesis, structural characterization, and optical studies of ultrathin Ge-Si superlattices, grown by molecular beam epitaxy, on (001) silicon substrates. Structures consist of alternating layers of pure Ge and Si, with layer thicknesses of 1, 2, 4, and 6 monolayers. Using high-resolution transmission electron microscopy, we provide direct observation of order in these pseudomorphic layered films. Systematic study of optical transitions by means of Schottky barrier electroreflectance reveals that each of the ordered structures displays a unique set of optical transitions. Of particular interest is the 4×4 structure which shows new, well defined optical transitions at 0.76, 1.25, and 2.31 eV. These transitions constitute the first observation of structurally induced optical transitions in Ge-Si and may make the 4×4 structure suitable for optoelectronic devices.
Real-time recognition of broadcast radio speech (2002)

This paper presents a real-time speech recognition system used to transcribe broadcast radio speech. The system is based on ABBOT, the hybrid connectionist-HMM large vocabulary continuous speech recognition system developed at the Cambridge University Engineering Department. Developments designed to make the system more robust to acoustic variability and to improve performance when decoding spontaneous speech are described. Modifications necessary to increase the speed of the system so that it operates in real-time are also described. Recognition results and latency figures are presented for speech collected from broadcast news segments on BBC Radio 4.
Digital Compatible HDTV Using Upconverted NTSC Video (1993)

The purpose of this article is to show that broadcasters and television post-production houses can economically make the transition to simulcasting high-definition television (HDTV) by upconverting NTSC video to digital spectrum-compatible (DSC) HDTV. All NTSC video source equipment, studios, cameras, tape equipment, telecines, and current libraries can be used in connection with an NTSC DSC-HDTV upconverter, described here.
Effect of indomethacin on bone destruction during experimental periodontal disease in the hamster (1983)

A major event in periodontitis is the destruction of alveolar processes. It is demonstrated that indomethacin (IND), an inhibitor of prostaglandin synthesis, can inhibit bone resorption in vitro . The aim of this study was to test the effect of IND on bone destruction in hamster periodontal disease. Its action was compared to calcitonin (CT), an inhibitor of osteoclastic resorption. IND decreased the macroscopic bone loss by 28% and the number of osteoclasts per mm by 55% in diseased animals but not significantly. Conversely CT reduced significantly bone loss (p<0.05) and decreased the number of osteoclasts to the control level (p<0.01). The combination of the two drugs had the same effect than CT alone on the two parameters. These results show an effect of IND on bone destruction but an inhibitory action on prostaglandin synthesis can only be hypothesized. In this model of periodontitis CT appears more effective than IND.
Modern Techniques in Applied Molecular Spectroscopy (1998)

Transmission Infrared Spectroscopy (R. Duerst, et al). Specular Reflection Spectroscopy (R. Lippert, et al.). Attenuated Total Reflection Spectroscopy (F. Mirabella). Diffuse Reflectance Spectroscopy (J. Blitz). Photoacoustic Spectroscopy (J. McClelland, et al.). Infrared Microspectroscopy (J. Katon). Raman Microspectroscopy (A. Sommer). Emission Spectroscopy (S. Zhang, et al.). Fiber Optics in Molecular Spectroscopy (C. Brown). References. Index.
FINE-a feature design environment (for intelligent networks) (1989)

The introduction of intelligent networks will cause a dramatic increase in the number of new features demanded by the telecom market. In order to fulfil these demands, the current software design cycle must be shortened. Simultaneously the software engineering community is trying to handle the software crisis by introducing IPSEs (Integrated Project Support Environments) as the glue for the application tools. FINE (Feature INteractive Environment) is a prototype system, to support the design of feature programs, based on the IPSE architecture. A feature program (e.g. some subscriber service) is implemented as an addition to POTS. The architecture is composed of three main subsystems-UIMS (User Interface Management System), a set of tools and a database. >
A Prospective Multicenter Registry on the Accuracy of Pedicle Screw Placement in the Thoracic, Lumbar, and Sacral Levels With the Use of the O-arm Imaging System and StealthStation Navigation (2012)

The use of the O-arm in combination with a navigation system increases the accuracy of pedicle screw placement. The accuracy of the surgeon's perception and the need to limit the radiation dose for the patient justify an additional CT scan only after careful assessment of the potential additional value.
Particle Concentration in Exhaled Breath (1987)

Measurements were made of the number concentrations of particles in exhaled breath under various conditions of exercise. A laser light scattering particle spectrometer was used to count particles exhaled by test subjects wearing respirators in a challenge environment of clean, dry air. Precautions were taken to ensure that particles were not generated by the the respirators and that no extraneous water or other particles were produced in the humid exhaled air. The number of particles detected in exhaled air varied over a range from less than 0.1 to about 4 particles per cm3 depending upon the test subject and his activity. Subjects at rest exhaled the lowest concentration of particles, whereas exercises producing a faster respiration rate caused increased exhalation of particles. Exhaled particle concentrations can limit the usefulness of nondiscriminating, ambient challenge aerosols for the fit testing of highly protective respirators.
Efficient construction of fixed-stride multibit tries for IP lookup (2002)

Srinivasan and Varghese (1999) have proposed the use of multibit tries to represent routing tables used for Internet (IP) address lookups. They propose an O(k*W/sup 2/) time dynamic programming algorithm to determine the strides of an optimal k-level multibit fixed-stride trie when the longest prefix in the routing table has length W. The authors improve on this algorithm by providing an alternative dynamic programming formulation. While the asymptotic complexity of the resulting algorithm for fixed-stride tries is the same as that of the algorithm of Srinivasan and Varghese, experiments using real IPv4 routing table data indicate that their algorithm runs 2 to 4 times as fast.
The disulfide bond connecting the chains of ricin. (1978)

Studies on the disulfide bond connecting the two polypeptide chains of ricin are reported. Reduction of this bond in the native protein requires approximately 50-fold more mercaptoethanol than the reduction of the bond in the protein denatured by sodium dodecyl sulfate. An improved procedure for the formation of this disulfide bond from recombined chains is reported. A and B chains spontaneously and rapidly reassociate into a stable complex with a sedimentation velocity similar to that of native oxidized ricin before the disulfide bond reforms. The mixture of both chains also behaves on Bio-Gel P-100 like native oxidized ricin. However, the complex formed by the two chains, assayed before the disulfide bond can reform, and reduced ricin, carboxymethylated to prevent reoxidation, shows a significant decrease in toxicity to mice and a decrease in ability to inhibit protein synthesis in HeLa cells in culture.
GABA and affective disorders. (1987)

Recently sufficient evidence has accumulated to propose that a central GABAergic dysfunction may be primarily related to the pathology of affective disorders and that antidepressant mechanisms (pharmacological or electroconvulsive therapy, ECT) have an intrinsic GABAergic component. In depressed patients GABA levels are reported to be low in the CSF and plasma, and GABA synthesis is decreased in some brain areas, including the frontal cortex. GABAmimetics such as progabide and fengabine exert a therapeutic effect in depression. In behavioural laboratory models GABAmimetics exhibit antidepressant-like actions in the olfactory bulbectomized rat and in rats submitted to an inescapable shock (learned helplessness). Furthermore, antidepressant GABAmimetics decrease paradoxical sleep. In the olfactory bulbectomized rat, GABAB receptors are downregulated in the frontal cortex and in the learned helplessness model, GABA release is diminished in the hippocampus. These decreases are reversed by antidepressants in parallel with their behavioural activities. An intrinsic activity of widely varied antidepressants and ECT is the upregulation of GABAB receptors in the frontal cortex. This, together with the downregulation of beta-adrenergic receptors induced by these compounds, and the GABAB modulation of the beta-adrenergic second messenger system, strongly suggest that both GABAergic and beta-adrenergic responses are inherent to an antidepressant effect.
Monocular Semantic Occupancy Grid Mapping With Convolutional Variational Encoder–Decoder Networks (2019)

In this letter, we research and evaluate end-to-end learning of monocular semantic-metric occupancy grid mapping from weak binocular ground truth. The network learns to predict four classes, as well as a camera to bird's eye view mapping. At the core, it utilizes a variational encoder–decoder network that encodes the front-view visual information of the driving scene and subsequently decodes it into a two-dimensional top-view Cartesian coordinate system. The evaluations on Cityscapes show that the end-to-end learning of semantic-metric occupancy grids outperforms the deterministic mapping approach with flat-plane assumption by more than 12% mean intersection-over-union. Furthermore, we show that the variational sampling with a relatively small embedding vector brings robustness against vehicle dynamic perturbations, and generalizability for unseen KITTI data. Our network achieves real-time inference rates of approx. 35 Hz for an input image with a resolution of 256 × 512 pixels and an output map with 64 × 64 occupancy grid cells using a Titan V GPU.
Pretreatment of Steel Racetracks by using a Sand-Blasting Technique with a Special Emphasis on Si<sub>3</sub>N<sub>4</sub>Powder—Part One (2008)

A fresh concept of using cavity-saturated racetracks to improve the bearing fatigue life is being explored in this work. Three different types of sand-blasted steel races, with 120-mesh and 220-mesh Al 2 O 3 powders and an ultrafine Si 3 N 4 powder as the blasting medium, respectively, have been tested in both “all-metal” and “hybrid” bearings. Preliminary results of the fatigue life and SEM/AES analyses reveal some preferable tribological traits for the Si 3 N 4 sand-blasted 52100 steel race.
Using Selection to Identify and Chemical Microarray to Study the RNA Internal Loops Recognized by 6′‐<i>N</i>‐Acylated Kanamycin A (2007)

Herein, we describe our initial steps towards identifying the RNA secondary structure motifs that are recognized by small molecules. We selected members of an RNA 3x3 internal loop motif library that bind kanamycin A, an RNA-binding aminoglycoside antibiotic, by using only one round of selection. A small internal-loop library was chosen because members are likely to be present in other larger, biologically relevant RNAs. We have identified several internal loops of various size and base composition that kanamycin A prefers to bind. The highest affinity structures are two 5'-UU/3'-CU 2x2 internal loops closed by AU pairs. Binding is specific for the selected internal loops with the highest affinities, since binding to the RNA cassette used to display the library or to DNA is >150-fold weaker. Enzymatic mapping experiments also confirm binding of kanamycin A to the internal loops. This method lays the foundation for finding RNA secondary structure elements that bind small molecules and for interrogating factors affecting RNA-ligand interactions. Information from these and subsequent studies will: 1) facilitate the rational and modular design of drugs or probes that bind target RNAs with high affinity, provided the secondary structure of the target is known and 2) give insight into the potential bystander RNAs that aminoglycosides bind.
Angiotensin-Converting Enzyme in the Human Nasal Mucosa (1994)

Angiotensin-converting enzyme (ACE; EC 3.4.15.1) may participate in respiratory inflammatory diseases by regulating levels of inflammatory peptides such as bradykinin. The presence of ACE in the human nasal mucosa and in nasal secretions was determined by immunohistochemistry, measures of enzyme activity, and immunoblot. ACE activity was significantly more abundant in the membrane-rich fraction than in the soluble cytosolic fraction of nasal mucosal extracts (74.18 +/- 24.50 versus 3.99 +/- 1.83 pmol/min/mg protein, respectively, P < 0.01 by an enkephalin degradation assay; 89.16 +/- 16.17 versus 2.30 +/- 0.89 mU/mg protein, P < 0.01 by colorimetric assessment of Bz-Gly-Gly-Gly degradation). Topical application of histamine stimulated secretion of ACE activity into nasal lavage fluid (2.90 +/- 0.88 versus 1.53 +/- 0.45 U/liter after saline provocation, P < 0.05 by Bz-Gly-Gly-Gly assay). Allergen challenge also induced nasal secretion of ACE. In both histamine and allergen challenges, ACE release correlated closely with that of the vascular proteins IgG and albumin. Methacholine, a stimulant of glandular secretions, failed to augment ACE levels above baseline. ACE-immunoreactive material was localized by the immunogold technique with silver enhancement to the glycocalyx, between epithelial cells, and to interstitial, extracellular sites in the superficial lamina propria, with the highest intensity of staining immediately beneath the basement membrane. Some ACE was detectable in the mucus material of gland and duct lumens but not in gland cells themselves. Endothelial cells and some interstitial mononuclear cells also stained for ACE. ACE was identified by immunoblotting as a 150 kD band on SDS-PAGE.(ABSTRACT TRUNCATED AT 250 WORDS)
Stereomutation of Axially Chiral Aryl Coumarins (2010)

Coumarins substituted by an aryl group in position 4 display restricted rotation about the Ar-C4 bond, giving rise to conformational or configurational enantiomers (atropisomers) when such a restricted motion leads to a C(1) symmetry. The dynamics of the stereomutation processes of these axial enantiomers was monitored by dynamic NMR, dynamic enantioselective HPLC, or racemization kinetics, depending on the activation energies involved. These results were further supported by DFT computations. In the two cases where the enantiomers were sufficiently long living as to be physically separated at ambient temperature, the absolute configuration was determined by means of a theoretical simulation of their electronic circular dichroism spectra (ECD).