gebhart/patrepeval huggingface dataset:
A comparative study of the oral, intravenous, and subcutaneous administration of 3H-naltrexone to normal male volunteers. (1981)

3H-naltrexone was administered orally, intravenously, and subcutaneously to groups of normal, male, paid volunteers. The doses given were: 50 mg orally (specific activity 4 microCi/mg), 1 mg intravenously (specific activity 200 microCi/mg), and 5 mg subcutaneously (specific activity 30 microCi/mg). At these doses, the subjects did not experience any noticeable effects. Following intravenous injection, plasma levels of radioactivity were immediately high and declined rapidly during the first 30 minutes and declined gradually thereafter. Following oral or subcutaneous administration, maximal plasma levels were observed to occur one hour after dosing, and reached similar levels to those obtained when the drug was intravenously injected. This finding indicates the excellent bioavailability of naltrexone following oral or subcutaneous administration 3H-naltrexone and/or its metabolites were predominately excreted in the urine, and the renal excretion was similar for all three routes of administration. Fecal excretion is a minor pathway of elimination. The urinary and fecal excretion of 3H-naltrexone was studied in one subject for 133 hours after drug ingestion, and it was found that essentially all of the dose administered was excreted in this period.
Key-frame removal method for blendshape-based cartoon lip-sync animation (2006)

No abstract available.
Prostaglandins in the pericardial fluid modulate neural regulation of cardiac electrophysiological properties. (1990)

In response to various stimuli, the pericardium produces prostaglandins that might play a role in neural regulation of cardiac electrophysiological properties by modulating epicardial nerve effects. We determined the effects of various epicardial superfusates on efferent cardiac responses, induced by bilateral efferent ansae subclaviae (SS) and cervical vagal (VS) stimulation, and afferent cardiac reflexes elicited by intracoronary injections of bradykinin (25 micrograms) and nicotine (50 micrograms). Pericardial instillation of arachidonic acid in normal Tyrode's solution (3 micrograms/ml) increased the concentration of pericardial prostacyclin (PGI2), measured by radioimmunoassay as the stable metabolite 6-keto-PGF1 alpha, and of prostaglandin E2 (PGE2). Arachidonic acid superfusion reduced SS-induced shortening of sinus cycle length (SCL), atrio-His interval (AH), and effective refractory period (ERP) of the right and left ventricular myocardium and prevented intra-aortic angiotensin II (30 ng/kg/min) from augmenting SS effects on these variables. Pericardial arachidonic acid plus indomethacin (1 microgram/ml) eliminated the prostaglandin increase and restored the responses of SCL, AH, and ERP to SS and to angiotensin II infusion. Pericardial PGE2 (30 or 50 ng/ml) or PGI2 (50 ng/ml) reversibly suppressed SS-induced shortening of SCL and ERP. Pericardial arachidonic acid or PGI2, however, did not blunt the shortening of ERP induced by intravenous infusion of norepinephrine. Pericardial arachidonic acid did not affect VS-induced lengthening of ERP or the duration of sinus arrest, or arterial blood pressure and heart rate responses to bradykinin or nicotine. We conclude that an increase in the concentration of prostaglandins in the pericardial fluid inhibits efferent sympathetic nerve effects on cardiac electrophysiological variables and antagonizes the facilitatory action of angiotensin II on efferent sympathetic stimulation by acting at presynaptic sites. Increased concentration of pericardial prostaglandins in response to various stimuli may constitute a physiological negative-feedback control mechanism that regulates efferent cardiac sympathetic stimulation.
DR αβ dimers released from complexes with invariant chain fail to stimulate alloreactive T cell clones (1993)

Abstract To demonstrate that DR αβ dimers still complexed to invariant chain (Ii) have not yet acquired peptides recognized by alloreactive T cells, complexes between DR molecules and Ii isolated from Epstein‐Barr‐virus (EBV)‐transformed B cells were analyzed by affinity chromatography and gel filtration. First, it was shown that DR/Ii complexes inserted into artificial planar membranes (PM) failed to stimulate proliferative response of five alloreactive T cell clones and a polyclonal alloreactive Tcell line, while PM bearing mature DR αβ dimers from the same EBV‐B cells were stimulatory for the Tcell clones and the Tcell line. These findings indicate that either Ii inhibits binding of peptides to DR molecules or Ii hinders T cells recognition of peptide/DR complexes. Second, to discriminate between these two possibilities, DR αβ dimers, which were artificially released from complexes between DR molecules and Ii, were inserted into PM. These DR αβ dimers were devoid of alloreactive stimulatory capacity while fully capable of binding and presenting a tetanus toxin synthetic peptide to a specific Tcell clone, indicating that DR molecules released from complexes with Ii are empty. This study, by showing that DR molecules bound to Ii do not bear peptides recognized by alloreactive T cells, supports the notion that association of Ii with class II major histocompatibility complex (MHC) molecules prevents premature peptide loading and hence favors encounter with peptides derived from proteins of the extracellular compartment. Since allogeneic class II MHC molecules released from complexes with Ii were not stimulatory for five out of five alloreactive Tcell clones and a polyclonal alloreactive Tcell line, these data also indicate that, in most cases, alloreactive T cells recognize ligands constituted by complexes between allogeneic class II MHC molecules and specific peptides which derive from the antigen‐presenting cells themselves or serum proteins.
So Much to Learn from One Accident Crash of 737 on 25 February 2009 (2011)

Turkish Airlines Flight 1951 crashed short of its destination runway at Schiphol Airport, Amsterdam, Netherlands on February 25, 2009. Nine people lost their lives, 177 were injured, and the aircraft was a complete loss. There was an equipment failure in the left radio altimeter that caused the auto-throttle system to go into retard flare mode in anticipation of immediate landing when the aircraft was still near 2000 ft above terrain, There were indications and warnings of this condition to the crew but they were ignored. The throttle retardation was also temporarily masked by the aircraft being directed to intercept the localizer from above, a highly unusual procedure. The investigation found numerous instances of low altitude readings on the accident aircraft as well as on others. Also, the accident aircraft had experienced two instances of throttle retardation on recent flights. Poor reporting practices led the manufacturer and the certifying authorities to underestimate the prevalence of this failure pattern. It is concluded that in many instances actions and design decisions were based on the assumption further conditions will be within the normal envelope. This is a dangerous assumption that must be avoided if we want to maintain the fine safety record of commercial aviation.
[Clinical observation on treatment of acupuncture for different stages of Bell's palsy]. (2010)

Acupuncture has a good therapeutic effect for treatment of Bell's palsy, and the therapeutic effect is most obvious with intervention of treatment in the active stage.
The mitochondrial control region of Cervidae: evolutionary patterns and phylogenetic content (1997)

The mitochondrial control region (CR) sequence, also known as the D-loop, has been determined for six Cervidae (Artiodactyla, Ruminantia): the red and fallow deers (subfamily Cervinae), the bracket deer and two roe deers (subfamily Odocoileinae), and the Chinese water deer (Hydropotinae). These new sequences have been aligned with available cervid and bovid orthologues.
The Cholera Toxin A1 <sub>3</sub> Subdomain Is Essential for Interaction with ADP-Ribosylation Factor 6 and Full Toxic Activity but Is Not Required for Translocation from the Endoplasmic Reticulum to the Cytosol (2006)

Cholera toxin (CT) moves from the plasma membrane to the endoplasmic reticulum (ER) by retrograde vesicular traffic. In the ER, the catalytic CTA1 polypeptide dissociates from the rest of the toxin and enters the cytosol by a process that involves the quality control mechanism of ER-associated degradation (ERAD). The cytosolic CTA1 then ADP ribosylates Gsalpha, resulting in adenylate cyclase activation and intoxication of the target cell. It is hypothesized that the C-terminal A1(3) subdomain of CTA1 plays two crucial roles in the intoxication process: (i) it contains a hydrophobic domain that triggers the ERAD mechanism and (ii) it facilitates interaction with the cytosolic ADP-ribosylation factors (ARFs) that serve as allosteric activators of CTA1. In this study, we examined the role(s) of the CTA1(3) subdomain in CT intoxication. Full-length CTA1 constructs and truncated CTA1 constructs lacking the A1(3) subdomain were generated and used to conduct two-hybrid studies of interactions with ARF6, in vitro enzyme assays, in vivo toxicity assays, and in vivo processing/degradation assays. Direct, plasmid-mediated expression of CTA1 constructs in the ER or cytosol of transfected CHO cells was used to perform the in vivo assays. With these methods, we found that the A1(3) subdomain of CTA1 is important both for interaction with ARF6 and for full expression of enzyme activity in vivo. Surprisingly, however, the A1(3) subdomain was not required for ERAD-mediated passage of CTA1 from the ER to the cytosol. A possible alternative trigger for CTA1 to activate the ERAD mechanism is discussed.
Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors (1994)

(1994). Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors. Cancer Investigation: Vol. 12, No. 5, pp. 530-542.
The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2. (1994)

A chimeric (mouse-human) BC2 antibody (cBC2) was produced which may be used in the diagnosis and treatment of breast cancer. The BC2 variable region genes were amplified by polymerase chain reaction (PCR), using oligonucleotide primers homologous to the framework sequences of mouse VH and V kappa genes. The PCR products were used to create cBC2 expression vectors containing the mouse BC2 VH and V kappa and human constant region (IgG1 and K) genes. Chimeric antibody was produced following transfection of these constructs into Sp2/0 myeloma cells. Binding assays in vitro demonstrated that cBC2 had the same specificity for human milk fat globule membrane (HMFGM) and MUC1+ cells as mBC2, and bound antigen with a similar affinity (cBC2, Ka 5.53 +/- 2.09 x 10(8); mBC2, Ka 1.44 +/- 0.98 x 10(9)). Functionally, only cBC2 (5-25 micrograms ml-1), was able to mediate antibody-dependent cellular cytotoxicity (ADCC) with human effector cells, with 25% maximal specific lysis of MUC1+ cells at an E/T ratio of 100:1. Human complement-mediated lysis was minimal (10-15% specific lysis) with both mBC2 and cBC2. Neither cBC2 nor mBC2 was able to inhibit tumour growth in vivo in the absence of covalently coupled anticancer drugs. However, biodistribution studies demonstrated that both antibodies preferentially targeted MUC1+ tumour cells, with 17% of the injected dose of cBC2, as compared to 27% of mBC2, localized to the MUC1+ tumour at 24 h (less than 6% detected in any other tissue).
Synthesis and Screening for Anti-HIV Activity of Some N-Mannich Bases of Isatin Derivatives (1999)

The effect of about 12 new compounds of Mannich bases of isatin against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT. In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.
A 4 : 1 Transmission-Line Impedance Transformer for Broadband Superconducting Circuits (2012)

We present a 4 : 1 superconducting transmission-line impedance transformer for cryogenic applications. The device transforms 25 Ω in the coplanar waveguide to 6.25 Ω in the microstrip and is designed to operate at 20 mK. Calibrated measurements in a dilution refrigerator demonstrate a -3 dB bandwidth from 1.6 to 13 GHz. In a modified Ruthroff design, a small capacitor is integrated at the input as a direct-current block, making it suitable for biasing and matching to low-impedance active circuits, such as superconducting quantum interference device (SQUID) amplifiers.
Diffusion coatings for the protection of iron and steel (1969)

Zinc coatings are applied commercially by hot-dipping, electro-deposition, metal-spraying, cementation and vacuum deposition (see Table 5). Galvanizing (zinc hot-dipping) has been done for more than 200 years now and is undoubtedly the most widely-used form of metal coating. The production and pro-perties of these coatings have received intensive study over the last 10 years; much of this has been reported at the ‘International Conferences on Hot-Dip Galvanizing’.
Tannins of cornaceous plants. I. Cornusiins A, B and C, dimeric monomeric and trimeric hydrolyzable tannins from Cornus officinalis, and orientation of valoneoyl group in related tannins. (1989)

Cornusiin A (1), cornusiin B (2) and cornusiin C (3), new dimeric, monomeric and trimeric hydrolyzable tannins, were isolated from the fruits of Cornus officinalis (Cornaceae). Their structures, including the orientation of the valoneoyl group in 1 and 3, were established on the basis of chemical and spectroscopic data. 2,3-Di-O-galloyl-D-glucose (7), 1,2,3-tri-O-galloyl-beta-D-glucose, 1,2,6-tri-O-galloyl-beta-D-glucose, 1,2,3,6-tetra-O-galloyl-beta-D-glucose, gemin D (5), isoterchebin, tellimagrandin I (6) and tellimagrandin II were also isolated from the fruits. The orientation of the valoneoyl group in camptothin A (14) and that in camptothin B (15), which had been isolated from Camptotheca acuminata (Nyssaceae), were also determined based on that in 1.
Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis (1998)

p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.
OXIDATION OF CERTAIN METHYLPYRIDINES TO PYRIDINE CARBOXYLIC ACIDS (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOXIDATION OF CERTAIN METHYLPYRIDINES TO PYRIDINE CARBOXYLIC ACIDSGORDON BLACK, ELIZABETH DEPP, and B. B. CORSONCite this: J. Org. Chem. 1949, 14, 1, 14–21Publication Date (Print):January 1, 1949Publication History Published online1 May 2002Published inissue 1 January 1949https://pubs.acs.org/doi/10.1021/jo01153a003https://doi.org/10.1021/jo01153a003research-articleACS PublicationsRequest reuse permissionsArticle Views2081Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Adaptive frame selection algorithm for DVB-T (2002)

Orthogonal frequency division multiplexing (OFDM) systems transmit a guard-interval, inserted in front of the effective symbol period, using signals copied from some of the last parts of the effective symbol period. This guard-interval is used to reduce distortions due to multipath conditions. However, conventional OFDM systems produce inter-symbol interference (ISI) under severe multipath or pre-ghost channel conditions even though they accurately estimate the effective symbol period. Accordingly, the paper proposes a frame selection algorithm for a fast Fourier transform (FFT) operation in an OFDM receiver to remove the ISI produced in conventional OFDM systems under multipath conditions. The proposed algorithm replaces some of the rear parts of the effective symbol period with some of the guard-interval as an FFT input frame. The replaced period in the FFT input frame is changed according to the multipath environment. Four estimation methods for determining the replaced period are also described.
The potential of LC-NMR in phytochemical analysis (2001)

The coupling of high performance liquid chromatography with nuclear magnetic resonance spectroscopy (LC-NMR) is one of the most powerful methods for the separation and structural elucidation of unknown compounds in mixtures. The recent progress in pulse field gradients and solvent suppression, the improvement in probe technology, and the construction of high field magnets have given a new stimulus to this technique, which has emerged since the mid 1990s as a very efficient method for the on-line identification of organic molecules. LC-NMR thus represents a potentially interesting complementary technique to LC-UV-MS in phytochemical analysis for the detailed on-line structural analysis of natural products. Recent applications have fully demonstrated the usefulness of this technique. A brief review of the applications of LC-NMR in natural product chemistry is presented in this paper, and a summary of the basic principles and modes of operation of LC-NMR is provided. Selected examples of LC-NMR analyses of plant metabolites in crude extracts or in enriched fractions are outlined and used to illustrate the different strategies for employing the technique. The practical possibilities and limitations of LC-NMR in its application to the analysis of crude plant extracts are discussed by means of several examples. Analytical strategies involving LC multi-coupled (hyphenated) techniques for the chemical screening and dereplication of crude plant extracts are presented. An analysis of the future development of the technique with respect to its application in phytochemical analysis is also given.
Synthesis and utility of fluorogenic acetoxymethyl ethers (2010)

Phenolic fluorophores such as fluorescein, Tokyo Green, resorufin, and their derivatives are workhorses of biological science. Acylating the phenolic hydroxyl group(s) in these fluorophores masks their fluorescence. The ensuing ester is a substrate for cellular esterases, which can restore fluorescence. These esters are, however, notoriously unstable to hydrolysis, severely compromising their utility. The acetoxymethyl (AM) group is an esterase-sensitive motif that can mask polar functionalities in small molecules. Here, we report on the use of AM ether groups to mask phenolic fluorophores. The resulting profluorophores have a desirable combination of low background fluorescence, high chemical stability, and high enzymatic reactivity, both in vitro and in cellulo. These simple phenyl ether-based profluorophores could supplement or supplant the use of phenyl esters for imaging biochemical and biological systems.
An improved Canny edge detector and its realization on FPGA (2008)

Canny edge detector treats edge detection as a signal processing problem to design an optimal edge detector and has been widely used for edge detection. However, the traditional Canny edge detector has two shortcomings. First, the threshold of the algorithm needs to be set by manual. Secondly, the algorithm is very time consuming and can not be implemented in real time. A new self-adapt threshold Canny algorithm is proposed in this paper to solve the first problem. A pipelined implementation on FPGA for this new algorithm is also designed to solve the second problem. Experiment results are also given to show the efficiency of the proposed method.
Improved Tdnns Using Deep Kernels and Frequency Dependent Grid-RNNS (2018)

Time delay neural networks (TDNNs) are an effective acoustic model for large vocabulary speech recognition. The strength of the model can be attributed to its ability to effectively model long temporal contexts. However, current TDNN models are relatively shallow, which limits the modelling capability. This paper proposes a method of increasing the network depth by deepening the kernel used in the TDNN temporal convolutions. The best performing kernel consists of three fully connected layers with a residual (ResNet) connection from the output of the first to the output of the third. The addition of spectro-temporal processing as the input to the TDNN in the form of a convolutional neural network (CNN) and a newly designed Grid-RNN was investigated. The Grid-RNN strongly outperforms a CNN if different sets of parameters for different frequency bands are used and can be further enhanced by using a bi-directional Grid-RNN. Experiments using the multi-genre broadcast (MGB3) English data (275h) show that deep kernel TDNNs reduces the word error rate (WER) by 6% relative and when combined with the frequency dependent Grid-Rnn gives a relative WER reduction of 9%.
Robust Modelling of Soil Diffuse Reflectance Spectra by “Bagging-Partial Least Squares Regression” (2007)

Visible (vis), near infrared (NIR) and mid infrared (mid-IR) diffuse reflectance spectroscopy (DRS) coupled with partial least squares regression (PLSR) are increasingly being used in the agricultural and environmental sciences as an efficient complement to conventional laboratory analysis. The DRS techniques are rapid, relatively cheap and more efficient for obtaining data than conventional analysis, especially when a large number of samples and analyses are required. A single spectrum may be used to predict various physical, chemical and biological soil properties. The robustness of PLSR models and their predictions may be improved by combining the implementation of PLSR with bootstrap aggregation or “bagging”. Bagging aims to reduce the variance of predictions by aggregating a number of models obtained in the course of re-sampling. The aim of this work was to test the implementation of bagging with PLSR (bagging-PLSR) using vis-NIR and mid-IR soil diffuse reflectance spectra to predict soil organic carbon (OC). Bagging-PLSR was shown to: (i) be more robust than PLSR alone, (ii) be less prone to over fitting and improve prediction accuracy and (iii) provide a measure of the uncertainty of the models and their predictions.
"Submicron bipolar technology - new chances for high speed applications" (1986)

The paper demonstrates that bipolar technology is getting new powerful momentum based on: i) improvements in technology synergetically using MOS techniques and ii) new concepts such as self-aligned structures and polysilicon emitters. Exploiting these innovations is shown to drastically reduce parasitics and device dimensions thus considerably extending the domain of bipolar technology towards high speed as well as high complexity circuits. Furthermore the synergetical use of processing knowhow opens up chances to cut down development and production cost and to realize vital BICMOS technologies combining the inherent advantages of CMOS- and BIPOLAR-technologies.