gebhart/patrepeval huggingface dataset:
Electric Properties of Wet Whole Bone (1987)

Although clinical applications of electrical stimulation of bone growth are of value in the treatment of nonunion and several other bony defects, the mechanism involved is still not fully understood. Knowledge of the electric properties of bone is helpful in this regard because it facilitates analysis of current flow in bone during electrical stimulation, In this study, the frequency dependence of the impedance and phase-angle in wet whole bovine bone were determined using a modified four-point technique. The measurements were made in both circumferential and longitudinal directions. In general, impedance in the circumferential direction was higher than in the longitudinal direction. Large differences in impedance were found between cortical bone and marrow. Bone resistance and capacitance were measured at 1 KHz, and the values were used to calculate impedance employing a parallel-model equivalent circuit. The calculated impedance values compared well with those obtained experimentally.
Trazodone for the treatment of fibromyalgia: an open-label, 12-week study (2010)

This trial has been registered with ClinicalTrials.gov number NCT-00791739.
The Countervailing Actions of Myeloid and Plasmacytoid Dendritic Cells Control Autoimmune Diabetes in the Nonobese Diabetic Mouse (2007)

Islet Ag-specific CD4(+) T cells receive antigenic stimulation from MHC class II-expressing APCs. Herein, we delineate the direct in vivo necessity for distinct subsets of macrophages and dendritic cells (DC) in type 1 diabetes mellitus of the NOD mouse by using diphtheria toxin-mediated cell ablation. The ablation of macrophages had no impact on islet Ag presentation or on the induction of insulitis or diabetes in either transfer or spontaneous models. However, the ablation of CD11b(+)CD11c(+) DC led to the loss of T cell activation, insulitis, and diabetes mediated by CD4(+) T cells. When the specific myeloid DC subset was "added-back" to mice lacking total DC, insulitis and diabetes were restored. Interestingly, when NOD mice were allowed to progress to the insulitis phase, the ablation of DC led to accelerated insulitis. This accelerated insulitis was mediated by the loss of plasmacytoid DC (pDC). When pDC were returned to depleted mice, the localized regulation of insulitis was restored. The loss of pDC in the pancreas itself was accompanied by the localized loss of IDO and the acceleration of insulitis. Thus, CD11c(+)CD11b(+) DC and pDC have countervailing actions in NOD diabetes, with myeloid DC providing critical antigenic stimulation to naive CD4(+) T cells and pDC providing regulatory control of CD4(+) T cell function in the target tissue.
Depletion of CD34+ CD4+ cells in bone marrow from HIV-1-infected individuals (1999)

Pancytopenia as a consequence of bone marrow abnormalities is commonly seen in HIV-infected individuals. To examine the effect that HIV-1 has on hematopoietic cells, we compared hematopoietic properties of bone marrow samples from HTV+ patients at various stages of disease with bone marrow samples from uninfected donors. While the absolute number of recovered CD34+ cells and the cloning efficiency of these cells did not differ significantly in HIV+ donors, the percentage of CD34+ CD4+ cells was significantly depleted in late-stage HIV+ patients. We observed a direct correlation between the numbers of CD34+ CD4+ cells in the bone marrow and the peripheral CD4 count. Further characterization of the CD34+ CD4+ subpopulation demonstrated that these cells expressed lower levels of HLA-DR on their surface compared with CD34+ CD4- cells, suggesting an immature phenotype. We also found evidence for expression of HIV-1 coreceptors CXCR-4 and CKR-5 message and protein in CD34+ bone marrow cells. While this finding suggested that hematopoietic cells might be susceptible to HIV infection at an early stage of maturation, thus affecting different cell lineages as they matured, we did not find any evidence for infection of HIV in these cells. These data suggest that HIV affects early hematopoietic progenitor cells either directly or indirectly, and in particular CD34+ CD4+ cells. This finding has important implications for disease pathogenesis and for application of gene therapy approaches that use CD34+ hematopoietic cells.
Investigation of thermally induced .alpha.-deoxysilylation of organosilylated hydroxylamine derivatives as a general method for nitrene production (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of thermally induced .alpha.-deoxysilylation of organosilylated hydroxylamine derivatives as a general method for nitrene productionYoung Hwan Chang, Fang-Ting Chiu, and Gerald ZonCite this: J. Org. Chem. 1981, 46, 2, 342–354Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/jo00315a024https://doi.org/10.1021/jo00315a024research-articleACS PublicationsRequest reuse permissionsArticle Views1600Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prosthetic replacement of the rabbit medial meniscus (1993)

Implants of polyurethane-coated polyester (Dacron), polyurethane-coated PTFE (Teflon), or uncoated PTFE were used to substitute the medial rabbit meniscus, and were observed over a 3-month period. Joint mechanics were similar for sham-operation, meniscectomy, or substitution with a coated implant. Joints with an uncoated PTFE prosthesis tended to be less compliant and to show greater load dissipation during relaxation. Cartilage indentation showed softening with all alternatives compared to sham-operation. Ingrowth into the prosthesis periphery was best with the PTFE implants. Both types of coated prosthesis retained their original shape, in contrast to the uncoated prostheses. To the naked eye the cartilage appeared unaffected only after sham-operation or implantation of a coated PTFE prosthesis. Osteophyte formation was common with all alternatives except sham-operation. We conclude that replacement of the medial meniscus with coated prostheses, especially the PTFE, was better than meniscectomy or using the uncoated prosthesis. However, cartilage softening and osteophyte formation indicate that joint mechanics were not restored to normal.
Recovery protocols for shared memory database systems (1995)

Significant performance advantages can be gained by implementing a database system on a cache-coherent shared memory multiprocessor. However, problems arise when failures occur. A single node (where a node refers to a processor/memory pair) crash may require a reboot of the entire shared memory system. Fortunately, shared memory multiprocessors that isolate individual node failures are currently being developed. Even with these, because of the side effects of the cache coherency protocol, a transaction executing strictly on a single node may become dependent on the validity of the memory of many nodes thereby inducing unnecessary transaction aborts. This happens when database objects, such as records, and database support structures, such as index structures and shared lock tables, are stored in shared memory.In this paper, we propose crash recovery protocols for shared memory database systems which avoid the unnecessary transaction aborts induced by the effects of using shared physical memory. Our recovery protocols guarantee that if one or more nodes crash, all the effects of active transactions running on the crashed nodes will be undone, and no effects of transactions running on nodes which did not crash will be undone. In order to show the practicality of our protocols, we discuss how existing features of cache-coherent multiprocessors can be utilized to implement these recovery protocols. Specifically, we demonstrate that (1) for many types of database objects and support structures, volatile (in-memory) logging is sufficient to avoid unnecessary transaction aborts, and (2) a very low overhead implementation of this strategy can be achieved with existing multiprocessor features.
Mapping Interactions of Escherichia coli GreB with RNA Polymerase and Ternary Elongation Complexes (1999)

Escherichia coli GreA and GreB modulate transcription elongation by interacting with the ternary elongation complex (containing RNA polymerase, DNA template, and RNA transcript) to induce hydrolytic cleavage of the transcript and release of the 3'-terminal fragment. Hydroxyl radical protein footprinting and alanine-scanning mutagenesis were used to investigate the interactions of GreB with RNA polymerase alone and in a ternary elongation complex. A major determinant for binding GreB to both RNA polymerase and the ternary elongation complex was identified. In addition, the hydroxyl radical footprinting indicated major conformational changes of GreB, in terms of reorientations of the N- and C-terminal domains with respect to each other, particularly upon interactions with the ternary elongation complex.
Scholarship as Contribution to World Peace (2011)

Eric Stein was clearly one of the important legal scholars of our time. I enjoyed him as a colleague for more than three decades, and remained a friend afterward although we were separated by distance. Eric was truly dedicated to his scholarship, which was broadly concerned with international law and how it operates, but perhaps most significant to his legacy was his deep interest and personal involvement in the extraordinary beginnings and ongoing evolution of the European Union.
Low‐level laser irradiation modulates matrix metalloproteinase activity and gene expression in porcine aortic smooth muscle cells (2006)

LLLI stimulates SMC proliferation, stimulates collagen synthesis, modulates the equilibrium between regulatory matrix remodeling enzymes, and inhibits pro-inflammatory IL-1-beta gene expression. These findings may be of therapeutic relevance for arterial diseases such as aneurysm where SMC depletion, weakened extracellular matrix, and an increase in pro-inflammatory markers are major pathologic components.
B cell regulation in cancer and anti-tumor immunity (2017)

The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described. A significant contribution of immune regulatory cells, including regulatory T cells, to tumor progression has been widely reported. An emerging body of evidence has recently recognized a role for B cells in modulating the immune response to tumors and lymphoid malignancies. Regulatory B cells (Bregs) are a newly designated subset of B cells that have been shown to play a pivotal role in regulating immune responses involved in inflammation, autoimmunity and, more recently, cancer. Bregs can suppress diverse cell subtypes, including T cells, through the secretion of anti-inflammatory mediators, such as IL-10, and can facilitate the conversion of T cells to regulatory T cells, thus attenuating anti-tumor immune responses. Similar B-cell subpopulations have been reported to be recruited to the tumor but to acquire their immunosuppressive properties within the tumor bed and thereby attenuate anti-tumor immune responses. However, despite a pivotal role for Bregs in promoting inflammation and carcinogenesis, the phenotypic diversity of the cell surface markers that are unique to Bregs remains unclear in mice and humans. In this review, we summarize the characteristics of Bregs and review our current knowledge of Bregs and their inhibition of anti-tumor immune responses in murine tumor models and cancer patients.
Parametric stereo coder with only MDCT domain computations (2009)

A parametric stereo coder in the MDCT domain is introduced in this work. Psychoacoustic modeling, parameter estimation and stereo synthesis are implemented in the MDCT domain. The encoder requires only MDCT domain computations and hence results in lower computational complexity. In addition, a low-complexity bit allocation algorithm is used for adaptive quantization of the MDCT coefficients. Perceptual evaluation shows that the proposed audio coder performance is comparable with that of MPEG-2 AAC coder with lower complexity.
DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression (2008)

Modifications at the N-terminal tails of nucleosomal histones are required for efficient transcription in vivo. We analyzed how H3 histone methylation and demethylation control expression of estrogen-responsive genes and show that a DNA-bound estrogen receptor directs transcription by participating in bending chromatin to contact the RNA polymerase II recruited to the promoter. This process is driven by receptor-targeted demethylation of H3 lysine 9 at both enhancer and promoter sites and is achieved by activation of resident LSD1 demethylase. Localized demethylation produces hydrogen peroxide, which modifies the surrounding DNA and recruits 8-oxoguanine-DNA glycosylase 1 and topoisomeraseIIbeta, triggering chromatin and DNA conformational changes that are essential for estrogen-induced transcription. Our data show a strategy that uses controlled DNA damage and repair to guide productive transcription.
Anti-spoofing for display and print attacks on palmprint verification systems (2015)

A number of approaches for personal authentication using palmprint features have been proposed in the literature, majority of which focus on improving the matching performance. However, of late, preventing potential attacks on biometric systems has become a major concern as more and more biometric systems get deployed for wide range of applications. Among various types of attacks, sensor level attack, commonly known as spoof attack, has emerged as the most common attack due to simplicity in its execution. In this paper, we present an approach for detection of display and print based spoof attacks on palmprint verifcation systems. The approach is based on the analysis of acquired hand images for estimating surface re ectance. First and higher order statistical features computed from the distributions of pixel intensities and sub-band wavelet coeefficients form the feature set. A trained binary classifier utilizes the discriminating information to determine if the acquired image is of real hand or a fake one. Experiments are performed on a publicly available hand image dataset, containing 1300 images corresponding to 230 subjects. Experimental results show that the real hand biometrics samples can be substituted by the fake digital or print copies with an alarming spoof acceptance rate as high as 79.8%. Experimental results also show that the proposed spoof detection approach is very effective for discriminating between real and fake palmprint images. The proposed approach consistently achieves over 99% average 10-fold cross validation classification accuracy in our experiments.
ELECTRON HOLOGRAPHY: RECENT DEVELOPMENTS (1997)

With the ever increasing speed of modern computers, computing-power hungry applications as electron holography can become more interactive and user friendly and be available for live-time application. New phase unwrapping algorithms and improved reconstruction techniques are discussed together with new approaches to improve the signal/noise ratio in reconstructed phase and amplitude images. While the simplification (from the users point of view) of most routines relays on fast computers and speedy algorithms, the routines for improved signal to noise ratios require not only intensive image processing but automated instrument control as well.
Pet Ownership and Cardiovascular Risk (2013)

C ardiovascular disease (CVD) is the leading cause of death in the United States. 1 Despite efforts promoting primary and secondary CVD prevention, 2-8 obesity and physical inactivity remain at epidemic proportions, with >60% of Americans adults overweight or obese and >50% not performing recommended levels of physical activity. 9 Similarly, hypertension, hypercholesterolemia, and other CVD risk factors remain poorly controlled in many Americans. Despite numerous pharmacological and device-based advances in the management of patients with established CVD, morbidity and mortality associated with this condition remain substantial. Hence, a critical need exists for novel strategies and interventions that can potentially reduce the risk of CVD and its attendant morbidity and mortality.
Bin1, a Myc-interacting protein, functions as a tumor suppressor by engaging a novel cell death program (1999)

Bin1 is a ubiquitous nucleocytoplasmic adaptor protein that was identified through its ability to interact with c-Myc. Bin1 expression was lost in 50% of carcinoma cell lines and breast tumors analyzed, suggesting Bin1 may function as a tumor suppressor. To investigate this hypothesis, Bin1 was ectopically expressed in tumor cells. Bin1 prevented cell outgrowth in colony formation assays performed in a panel of tumor cells. Bin1 also prevented c-Myc-mediated malignant cell transformation through a mechanism dependent upon interaction between Bin1 and c-Myc. These effects were specific and not due to toxicity. Bin1 was also discovered to suppress the oncogenic activities of E1A and mutant p53 through a different mechanism which did not require the Myc-Binding-Domain (MBD) of Bin1. Bin1 mutants lacking the MBD could also suppress tumor cell growth, suggesting that Bin1 could act through c-Myc-independent mechanisms. To define the basis for the tumor suppressor properties of Bin1, tumor cells were infected with a recombinant Bin1 adenovirus and subjected to morphological and molecular analyses. Ectopic expression of Bin1 induced rapid loss of viability which had several features of apoptosis. However, caspase activation did not accompany cellular demise. This study characterized tumor suppressor properties of Bin1 and defined a role for Bin1 in a novel form of programmed cell death.
Enterprise application integration with XML and Java (2000)

High-value solutions for integrating enterprise and legacy systems XML, Enterprise JavaAPIs, and much more Techniques for building flexible, extensible EIA solutions Easy-to-read, fully-documented code throughout CD-ROM includes leading-edge software and code library for XML/Java integration! is the amazing new web standard for universal data interchange. With this book and XML you can integrate your applications without converting the code! -Charles F. GoldfarbIntegrate your enterprise with XML and Java!Enterprise Application Integration (EAI) links diverse applications, platforms, and operating systems so they work as one-and deliver powerful business results seamlessly. Platform-independent Java is one powerful tool for building EAI applications, and XML adds the missing link: robust mechanisms to exchange data with non-Java applications. Now there's a complete, step-by-step guide to using Java and XML together to deliver enterprise integration solutions that work! Enterprise Application Integration With XML and Java covers all this, and more: Demonstrating why XML is such a powerful EAI infrastructure solution Identifying your key requirements for sharing and exchanging data Building robust, high-performance Java applications for parsing and processing XML documents Moving data between Java and non-Java applications Integrating XML with relational databases Serializing Java objects into XML, and asynchronous messaging with XML Providing convenient references to XML 1.0 grammar and the W3C Document Object ModelWhether you're a technical manager planning for enterprise application integration, or a Java developer tasked with delivering it, Enterprise Application Integration With XML and Java delivers the in-depth solutions and real-world expertise you need.CD-ROM INCLUDEDThe CD-ROM contains extensive source code from the book, plus a remarkable library of leading-edge software and trialware, including: Bluestone Visual-XML desktop XML development environment; IBM XML4J Java-based parser; and Push-technologies SpiritWAVE2 implementation of the Java Messaging Service!
Capacity and Performance of Adaptive MIMO System Based on Beam-Nulling (2008)

In this paper, we propose a scheme called "beam-nulling" for MIMO adaptation. In the beam-nulling scheme, the eigenvector of the weakest subchannel is fed back and then signals are sent over a generated subspace orthogonal to the weakest subchannel. Theoretical analysis and numerical results show that the capacity of beam-nulling is closed to the optimal water-filling at medium SNR. Additionally, signal-to-interference-plus-noise ratio (SINR) of MMSE receiver is derived for beam-nulling. Then the paper presents the associated average bit-error rate (BER) of beam-nulling numerically which is verified by simulation. Simulation results are also provided to compare beam-nulling with beamforming. To improve performance further, beam-nulling is concatenated with linear dispersion code. Simulation results are also provided to compare the concatenated beam-nulling scheme with the beamforming scheme at the same data rate. Additionally, the existing beamforming and new proposed beam-nulling can be extended if more than one eigenvector is available at the transmitter. The new extended schemes are called multi-dimensional (MD) beamforming and MD beam-nulling. Theoretical analysis and numerical results in terms of capacity are also provided to evaluate the new extended schemes. Simulation results show that the MD scheme with LDC can outperform the MD scheme with STBC significantly when the data rate is high.
The phylogenetic structure of the genus Acinetobacter (1994)

16S rDNA sequence analysis was performed on the type strains of all validly described Acinetobacter species and five unnamed Acinetobacter strains. The phylogenetic analyses confirm that Acinetobacter is a coherent genus within the gamma subclass of Proteobacteria and that the species are phylogenetically well defined. A. calcoaceticus, A. lwoffii, A. johnsonii and A. haemolyticus form one cluster of closely related species, the pair A. junii and A. baumannii forms a second cluster. A. radioresistens stands phylogenetically isolated. The study reveals that three undescribed strains can be assigned to individually described species, while strains DSM 30009 and DSM 590 may represent two novel Acinetobacter species.