gebhart/patrepeval huggingface dataset:
Post-translational processing of <i>ras</i> proteins (1989)

Conference Article| October 01 1989 Post-translational processing of ras proteins A. I. MAGEE A. I. MAGEE 1Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, The Ridgewav, Mill Hill, London NW7 1AA, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (5): 875–876. https://doi.org/10.1042/bst0170875 Article history Received: May 08 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation A. I. MAGEE; Post-translational processing of ras proteins. Biochem Soc Trans 1 October 1989; 17 (5): 875–876. doi: https://doi.org/10.1042/bst0170875 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: Pal, palmitic acid, Far, farnesol © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Non-caveolar caveolins – duties outside the caves (2020)

Caveolae are invaginations of the plasma membrane that are remarkably abundant in adipocytes, endothelial cells and muscle. Caveolae provide cells with resources for mechanoprotection, can undergo fission from the plasma membrane and can regulate a variety of signaling pathways. Caveolins are fundamental components of caveolae, but many cells, such as hepatocytes and many neurons, express caveolins without forming distinguishable caveolae. Thus, the function of caveolins goes beyond their roles as caveolar components. The membrane-organizing and -sculpting capacities of caveolins, in combination with their complex intracellular trafficking, might contribute to these additional roles. Furthermore, non-caveolar caveolins can potentially interact with proteins normally excluded from caveolae. Here, we revisit the non-canonical roles of caveolins in a variety of cellular contexts including liver, brain, lymphocytes, cilia and cancer cells, as well as consider insights from invertebrate systems. Non-caveolar caveolins can determine the intracellular fluxes of active lipids, including cholesterol and sphingolipids. Accordingly, caveolins directly or remotely control a plethora of lipid-dependent processes such as the endocytosis of specific cargoes, sorting and transport in endocytic compartments, or different signaling pathways. Indeed, loss-of-function of non-caveolar caveolins might contribute to the common phenotypes and pathologies of caveolin-deficient cells and animals.
Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer (2012)

Ovarian cancer is the leading cause of death from gynecologic cancer. Improvement in the clinical outcome of patients is likely to be achieved by the identification of molecular events that underlie the oncogenesis of ovarian cancer. Here we show that the anaplastic lymphoma kinase (ALK) is aberrantly activated in ovarian cancer. Using an unbiased and global phosphoproteomic approach, we profiled 69 Chinese primary ovarian tumor tissues and found ALK to be aberrantly expressed and phosphorylated in 4 tumors. Genetic characterization of these ALK-positive tumors indicated that full-length ALK expression in two serous carcinoma patients is consistent with ALK gene copy number gain, whereas a stromal sarcoma patient carries a novel transmembrane ALK fusion gene: FN1-ALK. Biochemical and functional analysis showed that both full-length ALK and FN1-ALK are oncogenic, and tumors expressing ALK or FN1-ALK are sensitive to ALK kinase inhibitors. Furthermore, immunohistochemical analysis of ovarian tumor tissue microarray detected aberrant ALK expression in 2% to 4% serous carcinoma patients. Our findings provide new insights into the pathogenesis of ovarian cancer and identify ALK as a potential therapeutic target in a subset of serous ovarian carcinoma and stromal sarcoma patients.
Switched, Fast, and Gigabit Ethernet, Third Edition (1998)

From the Publisher:
Switched, Fast, and Gigabit Ethernet, Third Edition is the one and only solution needed to understand and fully implement this entire range of Ethernet innovations. Acting both as an overview of current technologies and hardware requirements as well as a hands-on, comprehensive tutorial for deploying and managing Switched, Fast, and Gigabit Ethernets, this guide covers the most prominent present and future challenges network administrators face.
SHORT NOTICES (1964)

Journal Article SHORT NOTICES Get access The Problem of ‘Curse’ in the Hebrew Bible. By HERBERT CHANAN BRICHTO. Pp. x+232. (Journal of Biblical Literature Monograph Series, vol. XIII.) Philadelphia: Society of Biblical Literature and Exegesis, 1963. $2. A. S. HERBERT A. S. HERBERT Search for other works by this author on: Oxford Academic Google Scholar The Journal of Theological Studies, Volume XV, Issue 2, October 1964, Pages 497-b–497, https://doi.org/10.1093/jts/XV.2.497-b Published: 01 October 1964
Behavioral changes of adolescents in drug abuse intervention programs (1988)

Reduction of problem behaviors (drug and alcohol use, school problems, and legal involvement) by Mexican-American youth (N = 326) during their first 3 months in drug abuse intervention programs was related negatively to peer drug use during the program and was related positively to the amount of family support available during the program, participation in program activities, and a background of religious involvement. These findings support previous research that has shown the importance of peer influences and commitment to conventional structures of family and religion in relation to adolescent problem behaviors. These findings suggest that two goals that adolescent drug abuse programs should stress are working heavily on developing positive peer relations and family support while they encourage disassociation from deviant friends.
Effects of Tamoxifen on Hepatic Fat Content and the Development of Hepatic Steatosis in Patients with Breast Cancer: High Frequency of Involvement and Rapid Reversal After Completion of Tamoxifen Therapy (2003)

Tamoxifen had a statistically significant influence on hepatic fat content and was associated with frequent development of hepatic steatosis. Radiologists should be aware of this phenomenon and the possible occurrence of hepatic dysfunction and should differentiate steatosis from metastasis in postoperative patients with breast cancer.
A Low-Voltage High-Performance Differential Static Logic (LVDSL) family (2003)

A new logic family, Low-Voltage Differential Static Logic (LVDSL), is proposed for portable digital signal processing (DSP) applications. This circuit technique is capable of operating at a supply voltage lower than the minimum of complementary CMOS logic. It achieves low-power consumption by an aggressively reduced supply voltage, while maintaining speeds suitable for most portable DSP applications. At a supply of 1.2 V, a LVDSL full-adder consumes 6.52/spl times/ less energy and is 5/spl times/ faster than DCVS. It also consumes 2/spl times/ less energy and is 2.2/spl times/ faster than any of the established pass-logic families.
Assessment of Vertically Integrated Liquid (VIL) Water Content Radar Measurement (2003)

Vertically integrated liquid (VIL) water content is a parameter obtained from a radar performing voluminal scanning. This parameter has proven useful in the detection of severe storms and may be a worthwhile indicator for very short-term rainfall forecasting methods. Unfortunately, no information is available on the accuracy of VIL radar measurements. The present paper addresses this issue by means of simulation. Reference VILs are defined from vertical profiles of drop size distributions (DSD). These profiles make it possible to simulate the corresponding vertical profiles of reflectivity as well as the radar measurements used to deduce the VIL, as estimated classically (i.e., application of a classical relationship between equivalent radar reflectivity factor Ze and liquid water content M adapted to raindrops). A comparison of the reference VIL to the corresponding estimate then allows estimating radar measurement error. The VIL measurement error is first studied from two hypothetical, yet realistic, vertical profiles of DSD: one typical of stratiform rain and the other typical of a convective situation. A sensitivity analysis with respect to both meteorological conditions and radar operating conditions is also performed on these two profiles. For the convective case, use of a classical Ze–M relationship adapted to liquid water results in a significant underestimation of the reference VIL value. The same effect applies to the stratiform profile, even though brightband phenomena can compensate for this underestimation and lend the impression of smaller measurement error. A simple alternative method is proposed in order to reduce measurement errors. Both conventional and alternative VIL measurement methods are tested on the two theoretical profiles as well as on a series of actual vertical profiles of reflectivity. Better measurements are obtained with the alternative method, provided the altitude of the 0°C isotherm and the density of ice particles can be determined with reasonable precision. This alternative method for estimating VIL from radar data could serve to improve VIL measurement accuracy and would be worth applying to a longer series of observed data.
Viewsphere: A GIS-Based 3D Visibility Analysis for Urban Design Evaluation (2007)

Previously, GIS-based visibility analysis has been conducted mainly in two dimensions, based on the concept of an isovist in the built environment or the concept of a viewshed in terrain and landscape analysis. The Viewsphere, a GIS approach towards 3D visibility analysis is proposed for measuring visible urban space quantitatively in a way that is different from its predecessors, the isovist and the viewshed. A test case of Singapore's urban space was conducted by evaluating the visibility of three alternative urban design scenarios and their potential impacts on the visual quality of open space. Both directional and nondirectional approaches were applied to the mapping of visibility based on the 2D and 3D indices. The proposition that 3D visibility indices are more effective than 2D indices was verified. The findings show that the 3D indices are sensitive to the changes of z-dimension.
Tumor‐specific antigens in cutaneous T‐cell lymphoma: Expression and sero‐reactivity (2003)

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of extra-nodal non-Hodgkin lymphomas with primary manifestation in the skin with poor treatment options in the advanced stages. As basis for future immune-therapeutic strategies we have investigated the possible expression of tumor-specific targets in CTCL focusing mainly on so-called cancer-germline genes. cDNAs derived from 20 CTCL tissues and 4 CTCL cell lines were tested with 15 gene-specific and 4 gene family-specific primers by RT-PCR and confirmative Northern blotting. The most frequently detected mRNAs were LAGE-1 (55% with only partial coexpression of the splicing variants), cTAGE-1 (35%), MAGE-A9 (27%) and the GAGE-3-7 group (35%). Furthermore, we could detect NY-ESO-1 (21%) and a MAGE-A subgroup (15%), whereas sub-specification of the latter proved absence of MAGE-A1, -A2, -A3, -A6 and -A12. SCP-1 was found in only one specimen and a several antigens could not been detected in any tumor tissue or cell line (MAGE-B, GAGE-1,2,8 and all 4 RAGE genes). 90% of all CTCL samples were positive for at least 1 of the frequent mRNAs in RT-PCR (LAGE-1, NY-ESO-1, cTAGE-1, MAGE-A9, or GAGE-3to7). Using a secondary SEREX approach we could detect sero-reactivity in sera of CTCL patients against recombinant cTAGE-1 (10/29), GAGE (3/19), MAGE-A1 (1/18), -A3 (1/18), -A6 (2/18) and -A9 (4/18) protein, but not against LAGE-1a, MAGE-A4b or MAGE-A12 protein (n = 19). We conclude, that certain cancer-germline genes can be detected frequently in CTCL and are able to elicit a systemic immune response. These candidate genes might therefore be promising targets for immunotherapeutic interventions in CTCL.
Determination of Clausius–Mossotti factors and surface capacitances for colloidal particles (2011)

We propose a method to experimentally determine the Clausius–Mossotti factors and surface capacitances of colloidal particles. This two-step method is based on the following: (i) a precise positioning of particles on activated electrodes according to the applied frequency of an electric field and (ii) particles velocities measurements from a pure dielectrophoretic regime to build the Clausius–Mossotti factor. It confirms previous literature methods and measures the surface capacitance values for a wide range of particles such as polystyrene, silica, and gold whose diameters are at least 200 nm.
PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus (2014)

Sensitive molecular techniques are needed for rapid detection of the R292K oseltamivir-resistant mutant of influenza A(H7/N9) virus strain to monitor its transmission and guide antiviral treatment. We developed a real-time reverse transcription PCR and single nucleotide polymorphism probes to differentiate this mutant strain in mixed virus populations in human specimens.
pH-Dependent isotope exchange and hydrogenation catalysed by water-soluble NiRu complexes as functional models for [NiFe]hydrogenases (2008)

The pH-dependent hydrogen isotope exchange reaction between gaseous isotopes and medium isotopes and hydrogenation of the carbonyl compounds have been investigated with water-soluble bis(mu-thiolate)(mu-hydride)NiRu complexes, Ni(II)(mu-SR)(2)(mu-H)Ru(II) {(mu-SR)(2) = N,N'-dimethyl-N,N'-bis(2-mercaptoethyl)-1,3-propanediamine}, as functional models for [NiFe]hydrogenases. In acidic media (at pH 4-6), the mu-H ligand of the Ni(II)(mu-SR)(2)(mu-H)Ru(II) complexes has H(+) properties, and the complexes catalyse the hydrogen isotope exchange reaction between gaseous isotopes and medium isotopes. A mechanism of the hydrogen isotope exchange reaction between gaseous isotopes and medium isotopes through a low-valent Ni(I)(mu-SR)(2)Ru(I) complex is proposed. In contrast, in neutral-basic media (at pH 7-10), the mu-H ligand of the Ni(II)(mu-SR)(2)(mu-H)Ru(II) complexes acts as H(-), and the complexes catalyse the hydrogenation of carbonyl compounds.
Comparison of fault currents in multiterminal HVDC grids with different grounding schemes (2014)

The requirements of dc circuit breakers used to protect multiterminal HVDC networks are specified by the prospective fault current. The fault current, however, strongly depends on the grounding scheme of the network. Low-ohmic and high-impedance earthing practices with different grounding points are presented and compared with each other in terms of fault currents and overvoltages during a pole-to-ground fault. To do so, monopolar and bipolar configurations of a multiterminal HVDC cable network are implemented in PSCAD and simulations are performed.
Integration testing based on software couplings (2002)

Integration testing is an important part of the testing process, but few integration testing techniques have been systematically studied or defined. This paper presents an integration testing technique based on couplings between software components. The coupling-based testing technique is described, and 12 coverage criteria are defined. The coupling-based technique is also compared with the category-partition method on a case study, which found that the coupling-based technique detected more faults with fewer test cases than category-partition. This modest result indicates that the coupling-based testing approach can benefit practitioners who are performing integration testing on software. While it is our intention to develop algorithms to fully automate this technique, it is relatively easy to apply by hand.
Enantioselective Addition of Diethylzinc to Aldehydes in the Presence of Chiral Titanium Reagent Modified with<i>N</i>-Sulfonylated Amino Alcohol (1992)

Titanium(IV) isopropoxide modified with (1S,2R)-2-(p-methoxyphenylsulfonylamino)-1-phenylpropanol (9), was found to be an effective catalyst for enantioselective addition of diethylzinc to aldehydes. For example, benzaldehyde was converted into (S)-1-phenylpropanol in 97% enantiomeric excess.
Genome Wide Analysis Indicates Genes for Basement Membrane and Cartilage Matrix Proteins as Candidates for Hip Dysplasia in Labrador Retrievers (2014)

Hip dysplasia, an abnormal laxity of the hip joint, is seen in humans as well as dogs and is one of the most common skeletal disorders in dogs. Canine hip dysplasia is considered multifactorial and polygenic, and a variety of chromosomal regions have been associated with the disorder. We performed a genome-wide association study in Dutch Labrador Retrievers, comparing data of nearly 18,000 single nucleotide polymorphisms (SNPs) in 48 cases and 30 controls using two different statistical methods. An individual SNP analysis based on comparison of allele frequencies with a χ(2) statistic was used, as well as a simultaneous SNP analysis based on Bayesian variable selection. Significant association with canine hip dysplasia was observed on chromosome 8, as well as suggestive association on chromosomes 1, 5, 15, 20, 25 and 32. Next-generation DNA sequencing of the exons of genes of seven regions identified multiple associated alleles on chromosome 1, 5, 8, 20, 25 and 32 (p<0.001). Candidate genes located in the associated regions on chromosomes 1, 8 and 25 included LAMA2, LRR1 and COL6A3, respectively. The associated region on CFA20 contained candidate genes GDF15, COMP and CILP2. In conclusion, our study identified candidate genes that might affect susceptibility to canine hip dysplasia. These genes are involved in hypertrophic differentiation of chondrocytes and extracellular matrix integrity of basement membrane and cartilage. The functions of the genes are in agreement with the notion that disruptions in endochondral bone formation in combination with soft tissue defects are involved in the etiology of hip dysplasia.
Bier block with methylprednisolone and lidocaine in CRPS type I: a randomized, double-blinded, placebo-controlled study. (2005)

Bier block with methylprednisolone and lidocaine in CRPS type I does not provide long-term benefit in CRPS, and its short-term benefit is not superior to placebo.
Epitaxial growth and phase formation of austenitic stainless steel weld metals near fusion boundaries: Study of solidification and transformation of Cr-Ni stainless steel weld metals (3rd Report) (1998)

Summary This paper describes an investigation of the solidification behaviour of austenitic stainless steel weld metals at fusion boundaries, focusing particularly on epitaxial growth and primary phase selection. In the AF solidification mode, the planar austenite grows epitaxially from the austenite grains in the base metal. Ferrite subsequently forms at the dendrite boundaries of the primary austenite after the austenite changes from planar to dendritic. In the FA solidification mode, the planar austenite grows epitaxially from the austenite grains in the base metal as a result of competition between ferrite nucleation and austenite growth. Ferrite nucleation then ensues through enrichment of Cr in the liquid and ferrite subsequently continues to grow as the primary phase. The ferrite establishes the Kurdjumov-Sachs crystallographic orientation relationship (K-S relationship) with the planar austenite. At the stage of primary ferrite solidification, austenite solidifies as the second phase at the dendrite boundaries and has the same crystallographic orientation as the original planar austenite. During FA mode solidification of the sample with the lowest Cr-Ni ratio, it is also possible for the austenite to solidify as the primary phase because of solute fluctuations in the liquid and sub-cooling changes due to local changes in the temperature gradient in the liquid.
Development of a feedback stimulation for drowsy driver using heartbeat rhythms (2011)

We investigated the physiological response of a vibratory stimulation, which has the rhythm of heartbeats, and examined whether it is useful for the feedback stimulation for drowsy driving. We evaluated the efficiency of 4 types of vibratory rhythms for stimulation by using the sleepiness level estimated by the multiple linear regression model made from the indices of ECG and respiration. As the result, the vibratory rhythm, which has the real time heartbeats of subjects themselves, had an effect of inducing their physiological condition closer to the condition when they were struggling against the drowsiness. We concluded that the stimulation might be useful to prevent a drowsy driving if we could give it to the driver before he or she gets the severe drowsiness.
cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis (2020)

Endometriosis is a major cause of infertility and pelvic pain, affecting more than 10% of reproductive-aged women. Progesterone resistance has been observed in the endometrium of women with this disease, as evidenced by alterations in progesterone-responsive gene and protein expression. cAMP-Response Element-Binding 3-like protein 1 (Creb3l1) has previously been identified as a progesterone receptor (PR) target gene in mouse uterus via high density DNA microarray analysis. However, CREB3L1 function has not been studied in the context of endometriosis and uterine biology. In this study, we validated progesterone (P4) regulation of Creb3l1 in the uteri of wild-type and progesterone receptor knockout (PRKO) mice. Furthermore, we observed that CREB3L1 expression was significantly higher in secretory phase human endometrium compared to proliferative phase and that CREB3L1 expression was significantly decreased in the endometrium of women with endometriosis. Lastly, by transfecting CREB3L1 siRNA into cultured human endometrial stromal cells (hESCs) prior to hormonal induction of in vitro decidualization, we showed that CREB3L1 is required for the decidualization process. Interestingly, phosphorylation of ERK1/2, critical factor for decidualization, was also significantly reduced in CREB3L1-silenced hESCs. It is known that hESCs from patients with endometriosis show impaired decidualization and that dysregulation of the P4-PR signaling axis is linked to a variety of endometrial diseases including infertility and endometriosis. Therefore, these results suggest that CREB3L1 is required for decidualization in mice and humans and may be linked to the pathogenesis of endometriosis in a P4-dependent manner.
STUDIES OF POLYAZAPENTALENES. III. ELECTROPHILIC REACTIONS OF 8-SUBSTITUTED DIBENZO[<i>b</i>,<i>e</i>]-1,3<i>a</i>,6<i>a</i>-TRIAZAPENTALENE (1973)

Abstract It has been found that the substitution occurs at 7-position of 8-substituted dibenzo-1,3a,6a-triazapentalene in the electrophilic reactions. This is compatible with the results of HMO and SCF-MO calculations.