gebhart/patrepeval huggingface dataset:
A large-scale contents distribution architecture based on reliable multicast (2003)

Communication networks have matured to realize on-line distribution of digital contents. This paper proposes a contents distribution architecture which makes a large-scale contents delivery available using multicast and emerging broadcast networks. Multicast is a promising network technology to provide large-scale efficient delivery. However, the issues of reliable and restricted data delivery using multicast need to be solved to realize a practical contents distribution. A reliable multicast tool is proposed for error free and confirmed delivery to thousands of users. A contents distribution procedure including service access control and delivery charge is also proposed for commercial distribution services.
NVIDIA cuda software and gpu parallel computing architecture (2007)

In the past, graphics processors were special purpose hardwired application accelerators, suitable only for conventional rasterization-style graphics applications. Modern GPUs are now fully programmable, massively parallel floating point processors. This talk will describe NVIDIA's massively multithreaded computing architecture and CUDA software for GPU computing. The architecture is a scalable, highly parallel architecture that delivers high throughput for data-intensive processing. Although not truly general-purpose processors, GPUs can now be used for a wide variety of compute-intensive applications beyond graphic.
El rondallari aguiló: transcripció, catalogació i estudi introductori (2006)

Ni disponemos del resumen de esta tesis doctoral. EL RONDALLARI AGUILO: TRANSCRIPCIO, CATALOGACIO I ESTUDI INTRODUCTORI
[Adsorption kinetic study of the interaction between human salivary alpha-amylase and the polyphenoles from the black/green tea]. (2011)

The sorely oral astringency is much easily produced by TF from the black tea rather than EGCG from the green tea. The driving force of the oral astringency is attributed to the hydrogen bonds of hydroxyl groups and hydrophobic interaction of galloyl groups in polyphenolic structures.
Effect of Water Concentration on the Properties of Commercial Soda‐Lime‐Silica Glasses (1990)

The effect of water concentration on the properties of three commercial soda‐lime‐silica glasses has been measured. Water (H 2 O) concentration varied from 50 to 550 ppm‐wt. Properties measured include glass transformation temperature, transformation range viscosity, thermal expansion coefficient, electrical conductivity, and refractive index. The viscosity, T g , and electrical conductivity decreased with increasing water content, while the thermal expansion coefficient and refractive index were unaffected by changes in water concentration.
Lipids in infant nutrition and their impact on later development (1996)

Numerous studies on infant nutrition show that breast-feeding has a beneficial effect on growth, morbidity, and neurological and cognitive functioning later in life. Moreover, there are indications that a relationship exists between the diet consumed during early childhood and morbidity in adulthood, such as atherosclerosis and insulin-dependent diabetes mellitus. The mechanism causing this advantageous effect of breast-feeding might be found in the fatty acid composition of human milk. The fatty acid content of formula milk is associated with biochemical parameters, cognitive development, and growth. Further research concentrating on randomized trials of 'fatty acid-enriched' formula milks is needed for the sake of children of mothers who opt for bottle-feeding.
Une histoire sociale à l'italienne ? (2008)

Résumé L’article est divisé en trois parties : la première dresse un tableau de la situation de l’histoire sociale depuis la fin de la seconde guerre mondiale, soit depuis la fin du fascisme et de son hostilité radicale à l’égard des sciences sociales. Dans les années 1940-1950, la reprise des études sur la société se fait sous le signe du marxisme et du parti communiste. Cependant, en dehors des partis et des universités, des travaux originaux sont menés par des écrivains et des sociologues, qui s’engagent dans une recherche sur la société se voulant être aussi un rendez-vous civil. La deuxième partie, consacrée aux années 1970, suit le débat sur l’histoire sociale, dans ses deux versions, labour history et microstoria . La troisième partie fait rapidement le tour de la production en histoire sociale dans les années 1980-1990, tant sur le versant de la microstoria que sur celui de la labour history , soulignant une sorte d’influence réciproque pour la période contemporaine, influence jamais admise mais évidente vu le déplacement des centres d’intérêts vers les territoires et vers le rôle de la société dans l’histoire des institutions. Même si les tendances internationales prédominent aujourd’hui, le territoire et la microstoria restent les traits particuliers de l’histoire sociale italienne, car ils sont très proches de ses spécificités géographiques et historiques.
Magnetic nanostructures for advanced technologies: fabrication, metrology and challenges (2011)

Magnetic nanostructures are an integral part to many state-of-the-art and emerging technologies. However, the complete path from parts (the nanostructures) to the manufacturing of the end products is not always obvious to students of magnetism. The paper follows this path of the magnetic nanostructure, and explains some of the steps along the way: What are the technologies that employ magnetic nanostructures? How are these nanostructures made? What is the physics behind the functional parts? How are the magnetic properties measured? Finally, we present, in our view, a list of challenges hindering progress in these technologies.
Effect of Malalignment and Friction on Contact Pressure in the Polyethylene Component in the Total Knee Replacement (2002)

The articulation of the femoral and tibial component contact surface is influenced by the alignment of these components. Malalignment of the total knee is perceived to increase the contact pressure and reduces the life of the polyethylene component. In this paper the contact pressure obtained from a experimental results [2] are used as the loading condition for a normal TKA alignment. In the case of a malalignment, we assumed that the loads at the interface do not change and the malalignment is to the femur component rotation. The results show that the pressure distribution is higher in the malaligned fit, which implies a reduced lifetime for the TKA. In the analysis, the experimental loads derived from cadaver knee testing are increased by a scale factor of 5, 10, 20, 50 to predict a more realistic loading condition of the knee. The effect of malrotation on the pressure distribution under these condition shows that the percentage change in the pressure distribution is slightly larger than that from the experimental loads.
Hyperbook Tools, an authoring tool (2002)

There are today many authoring tools available for every computer environment, In this paper a classification of authoring tools is made. One authoring tool is thoroughly discussed and examined. The different possibilities are compared with the problems they may give the author and the user of the complete system. What might there be ahead in the future?.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
N-Acylphenylalanines and related compounds. A new class of oral hypoglycemic agents (1988)

N-Benzoyl-DL-phenylalanine (1) was found to possess hypoglycemic activity. A series of the analogues of compound 1 were prepared and evaluated for their blood glucose lowering activity. Both the steric effects of the phenylalanine moiety and the effects of variations in the acyl moiety were investigated. This study elucidated some of the structure-activity relationships and led to the development of N-(4-ethylbenzoyl)-D-phenylalanine (34), which was 50 times more potent than the initial compound 1.
Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway (2008)

Infection with feline infectious peritonitis virus (FIPV), a feline coronavirus, frequently leads to death in spite of a strong humoral immune response. In previous work, we reported that infected monocytes, the in vivo target cells of FIPV, express viral proteins in their plasma membranes. These proteins are quickly internalized upon binding of antibodies. As the cell surface is cleared from viral proteins, internalization might offer protection against antibody-dependent cell lysis. Here, the internalization and subsequent trafficking of the antigen-antibody complexes were characterized using biochemical, cell biological and genetic approaches. Internalization occurred through a clathrin- and caveolae-independent pathway that did not require dynamin, rafts, actin or rho-GTPases. These findings indicate that the viral antigen-antibody complexes were not internalized through any of the previously described pathways. Further characterization showed that this internalization process was independent from phosphatases and tyrosine kinases but did depend on serine/threonine kinases. After internalization, the viral antigen-antibody complexes passed through the early endosomes, where they resided only briefly, and accumulated in the late endosomes. Between 30 and 60 min after antibody addition, the complexes left the late endosomes but were not degraded in the lysosomes. This study reveals what is probably a new internalization pathway into primary monocytes, confirming once more the complexity of endocytic processes.
Conscious perception of errors and its relation to the anterior insula (2010)

To detect erroneous action outcomes is necessary for flexible adjustments and therefore a prerequisite of adaptive, goal-directed behavior. While performance monitoring has been studied intensively over two decades and a vast amount of knowledge on its functional neuroanatomy has been gathered, much less is known about conscious error perception, often referred to as error awareness. Here, we review and discuss the conditions under which error awareness occurs, its neural correlates and underlying functional neuroanatomy. We focus specifically on the anterior insula, which has been shown to be (a) reliably activated during performance monitoring and (b) modulated by error awareness. Anterior insular activity appears to be closely related to autonomic responses associated with consciously perceived errors, although the causality and directions of these relationships still needs to be unraveled. We discuss the role of the anterior insula in generating versus perceiving autonomic responses and as a key player in balancing effortful task-related and resting-state activity. We suggest that errors elicit reactions highly reminiscent of an orienting response and may thus induce the autonomic arousal needed to recruit the required mental and physical resources. We discuss the role of norepinephrine activity in eliciting sufficiently strong central and autonomic nervous responses enabling the necessary adaptation as well as conscious error perception.
A VHDL-based simulation methodology for estimating switching activity in static CMOS circuits (2002)

Recently, power dissipation has become a major design constraint for complex VLSI circuits. Designers need tools that rapidly, but accurately, estimate power dissipation in a given design. Two categories of tools are useful for this purpose: (1) power optimization tools and algorithms tightly integrated with logic optimization, and (2) an analysis tool for estimating the power consumption in an existing netlist. This work addresses the latter issue by employing a VHDL-based approach for analysis of power consumption in static CMOS combinational logic designs. The circuits under test will be either the result of logic synthesis with various optimization constraints or hand designs done through schematic capture. The proposed approach will also be used to analyze various known architectures of the same network for power consumption, such as various forms of adders. The work presented in this article consists of three phases: (1) designing smart VHDL simulation models that first measure transition activity at each node of the netlist and then estimate the power based on this activity and on fanout at each node, (2) the generation of smart input stimuli that achieve an upper bound on transition activity and hence power consumption, and (3) analysis of different topologies of the same circuit. The estimates produced by this analysis may provide useful feedback to designers or synthesis tools, allowing for better exploration of the design space.
Chemically modified carbon paste electrodes in voltammetric analysis (1990)

Abstract A review of chemically modified carbon paste electrodes (CMCPEs) and their use in voltammetric analysis is presented. The different methods of modification as well as the types of interaction between substrate and modifier are discussed. In addition to a survey of the literature (173 references), the scope of and prospects in this field of electroanalysis are discussed briefly.
Cartesian oval representation of freeform optics in illumination systems (2011)

The geometrical method for constructing optical surfaces for illumination purpose developed by Oliker and co-workers [Trends in Nonlinear Analysis (Springer, 2003)] is generalized in order to obtain freeform designs in arbitrary optical systems. The freeform is created by a set of primitive surface elements, which are generalized Cartesian ovals adapted to the given optical system. Those primitives are determined by Hamiltonian theory of ray optics. The potential of this approach is demonstrated by some examples, e.g., freeform lenses with collimating front elements.
Legendre Fit to the Reflection Coefficient of a Radiating Rectangular Waveguide Aperture (2012)

We accurately calculate the reflection coefficient and normalized admittance of radiating open-ended rectangular waveguides and fit our results with a linear combination of Legendre polynomials. We verify the expression to an accuracy of 0.005 with other calculations and examine the impact of flanges and burrs on the accuracy to which the reflection coefficient can be approximated in practice.
A New Hashing Package for UNIX. (1991)

UNIX support of disk oriented hashing was originally provided by dbm [ATT79] and subsequently improved upon in ndbm [BSD86]. In AT&amp;T System V, in-memory hashed storage and access support was added in the hsearch library routines [ATT85]. The result is a system with two incompatible hashing schemes, each with its own set of shortcomings. This paper presents the design and performance characteristics of a new hashing package providing a superset of the functionality provided by dbm and hsearch. The new package uses linear hashing to provide efficient support of both memory based and disk based hash tables with performance superior to both dbm and hsearch under most conditions. Introduction Current UNIX systems offer two forms of hashed data access. Dbm and its derivatives provide keyed access to disk resident data while hsearch provides access for memory resident data. These two access methods are incompatible in that memory resident hash tables may not be stored on disk and disk resid...
Answering XPath Queries in Virtual XML Data Integration System (2008)

When data sources are virtually integrated, there is no materialized global instance available. In this paper, we consider the problem of computing answers when queries are posed to virtual XML data integration systems, which are specified following the local-as-view approach. In the view definition, edge-path mapping and data-value binding are supported. Given an XPath query on the global system, we provide a method to compute query answers based on the underlying data sources by reversing rules in the view definition.
Enzymic hydrolysis of glucosinolates in a low water system (1990)

Abstract The hydrolysis of glucosinolates by a co‐occurring thioglucosidase, myrosinase, produces a range of physiologically active compounds including organic isothiocyanates and nitriles. Myrosinase is known to be a membrane‐bound enzyme, thus the reaction with glucosinolates is likely to occur in vivo at an interface. Glucosinolates were hydrolysed in a low water system both with and without surfactant. In the former case, more rapid hydrolysis was observed than occurs in buffered aqueous solution. Desulphoglucosinolates were found to inhibit glucosinolate hydrolysis in this system.
Investigating Country Differences in Mobile App User Behavior and Challenges for Software Engineering (2014)

Mobile applications (apps) are software developed for use on mobile devices and made available through app stores. App stores are highly competitive markets where developers need to cater to a large number of users spanning multiple countries. This work hypothesizes that there exist country differences in mobile app user behavior and conducts one of the largest surveys to date of app users across the world, in order to identify the precise nature of those differences. The survey investigated user adoption of the app store concept, app needs, and rationale for selecting or abandoning an app. We collected data from more than 15 countries, including USA, China, Japan, Germany, France, Brazil, United Kingdom, Italy, Russia, India, Canada, Spain, Australia, Mexico, and South Korea. Analysis of data provided by 4,824 participants showed significant differences in app user behaviors across countries, for example users from USA are more likely to download medical apps, users from the United Kingdom and Canada are more likely to be influenced by price, users from Japan and Australia are less likely to rate apps. Analysis of the results revealed new challenges to market-driven software engineering related to packaging requirements, feature space, quality expectations, app store dependency, price sensitivity, and ecosystem effect.
Oxygenated allylic silanes: useful homoenolate equivalents for the stereoselective C-glycosidation of pyranoside derivatives (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygenated allylic silanes: useful homoenolate equivalents for the stereoselective C-glycosidation of pyranoside derivativesJames S. Panek and Michelle A. SparksCite this: J. Org. Chem. 1989, 54, 9, 2034–2038Publication Date (Print):April 28, 1989Publication History Published online1 May 2002Published inissue 28 April 1989https://pubs.acs.org/doi/10.1021/jo00270a005https://doi.org/10.1021/jo00270a005research-articleACS PublicationsRequest reuse permissionsArticle Views421Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells (2014)

Signaling lymphocytic activation molecule F7 (SLAMF7) is a receptor present on immune cells, including natural killer (NK) cells. It is also expressed on multiple myeloma (MM) cells. This led to development of an anti-SLAMF7 antibody, elotuzumab, showing efficacy against MM. SLAMF7 mediates activating or inhibitory effects in NK cells, depending on whether cells express or do not express the adaptor EAT-2. Since MM cells lack EAT-2, we elucidated the inhibitory effectors of SLAMF7 in EAT-2-negative NK cells and tested whether these effectors were triggered in MM cells. SLAMF7-mediated inhibition in NK cells lacking EAT-2 was mediated by SH2 domain-containing inositol phosphatase 1 (SHIP-1), which was recruited via tyrosine 261 of SLAMF7. Coupling of SLAMF7 to SHIP-1 required Src kinases, which phosphorylated SLAMF7. Although MM cells lack EAT-2, elotuzumab did not induce inhibitory signals in these cells. This was at least partly due to a lack of CD45, a phosphatase required for Src kinase activation. A defect in SLAMF7 function was also observed in CD45-deficient NK cells. Hence, SLAMF7-triggered inhibition is mediated by a mechanism involving Src kinases, CD45, and SHIP-1 that is defective in MM cells. This defect might explain why elotuzumab eliminates MM cells by an indirect mechanism involving the activation of NK cells.
Safety and exceptional immunogenicity of novel 5T4 viral vectored vaccination regimes in early stage prostate cancer: a phase I clinical trial (2020)

Abstract Prostate cancer (PCa) has been under investigation as a target for antigen-specific immunotherapies in metastatic disease settings for a decade. However, neither of the two clinically most developed prostate cancer vaccines, Sipuleucel-T and ProstVac, induce strong T cell immunity. In this first-in-man study, VANCE, we evaluated a novel vaccination platform based on two replication-deficient viruses, chimpanzee adenovirus (ChAd) and MVA (Modified Vaccinia Ankara), targeting the oncofetal self-antigen 5T4 in early stage PCa. Forty patients, either newly diagnosed with early stage prostate cancer and scheduled for radical prostatectomy or patients with stable disease on an active surveillance protocol, were recruited to the study to assess the vaccine safety and T cell immunogenicity. Secondary and exploratory endpoints included immune infiltration into the prostate, prostate specific antigen (PSA) change and assessment of phenotype and functionality of antigen-specific T cells. The vaccine had an excellent safety profile. Vaccination-induced 5T4-specific T cell responses were measured in blood by ex vivo IFN-γ ELISpot and were detected in the majority of patients with a mean level in responders of 198 spot-forming cells (SFC) per million peripheral blood mononuclear cells (PBMCs). Flow cytometry analysis demonstrated the presence of both CD8+ and CD4+ polyfunctional 5T4-specific T cells in the circulation. 5T4-reactive tumour infiltrating lymphocytes (TILs) were isolated from post-treatment prostate tissue. Some of the patients had a transient PSA rise 2-8 weeks following vaccination, possibly indicating an inflammatory response in the target organ. The potent T cell responses elicited support the evaluation of these vectored vaccine in efficacy trials.
A Double-Blind, Placebo-Controlled Trial Combining Sertraline and Naltrexone for Treating Co-Occurring Depression and Alcohol Dependence (2010)

More depressed alcohol-dependent patients receiving the sertraline plus naltrexone combination achieved abstinence from alcohol, had delayed relapse to heavy drinking, reported fewer serious adverse events, and tended to not be depressed by the end of treatment.