gebhart/patrepeval huggingface dataset:
Rational Transmitting Boundaries for Time-Domain Analysis of Dam-Reservoir Interaction (1994)

Most existing arch dams have been designed for seismic loading by static methods involving the use of seismic coefficients. Although there are no known examples of arch dams which have been seriously damaged by earthquakes, the need for more realistic seismic analyses is now well recognized, not only for new dams but especially in the context of the safety evaluation of existing dams. Fortunately, with the finite element method, engineers have a powerful tool for modeling the complex geometry and the nonlinear material behavior of a dam. However, there is still a major complication in the analysis procedure, namely the interaction of the dam with the reservoir and with the foundation during an earthquake. Interaction is a wave propagation problem involving transmitting boundaries. The State of the Art in engineering practice is to neglect wave propagation by modeling the water as incompressible and the foundation as massless. More advanced analysis methods using compressible water and foundation with mass have been available for some time. However, these methods are restricted to linear models, because they work in the frequency domain. On the other hand, there are also advanced nonlinear models for dams, but they can only be used in the time domain, usually with simple transmitting boundaries. In this report, which is based on an a doctoral thesis, rigorous transmitting boundaries in the time domain are developed which permit combining compressible water with n- linear dam behavior. The new numerical model is based on a systems-theory approach
Location Management Congestion Problem in Wireless Networks (2007)

We propose and study the location management congestion problem arising in the group mobility scenarios. In the hot-spot locations, e.g., supermarket, bus interchange, or public transportation systems, a large number of travelers move into the same area concurrently and trigger the location update (LU) procedure simultaneously to register their new locations. However, due to the limited bandwidth in a base station, only a small part of the LU requests has the opportunity to capture a radio channel and succeeds in refreshing the new information to the corresponding database in the wireless networks. The remaining mobile terminals (MTs) are unable to obtain a radio channel, and consequently, the LU requests are rejected. A significant consequence of a failed LU is the out-of-date location identity in the network databases and, thereafter, the incapability in establishing the valid route for the potential call connection request, which will seriously degrade the network quality-of-service (QoS). We develop a queueing model to characterize the congestion issue and propose a buffer scheme to eliminate this problem. The consequence of the LU failure on the MT's call activity is also investigated. The comparison demonstrates the high efficiency of the proposed approach in decreasing the LU failure as well as the resulting call blocking probability. The analytical model has been validated by the discrete event simulation
Complete Genome Sequence of the Genetically Tractable Hydrogenotrophic Methanogen <i>Methanococcus maripaludis</i> (2004)

The genome sequence of the genetically tractable, mesophilic, hydrogenotrophic methanogen Methanococcus maripaludis contains 1,722 protein-coding genes in a single circular chromosome of 1,661,137 bp. Of the protein-coding genes (open reading frames [ORFs]), 44% were assigned a function, 48% were conserved but had unknown or uncertain functions, and 7.5% (129 ORFs) were unique to M. maripaludis. Of the unique ORFs, 27 were confirmed to encode proteins by the mass spectrometric identification of unique peptides. Genes for most known functions and pathways were identified. For example, a full complement of hydrogenases and methanogenesis enzymes was identified, including eight selenocysteine-containing proteins, with each being paralogous to a cysteine-containing counterpart. At least 59 proteins were predicted to contain iron-sulfur centers, including ferredoxins, polyferredoxins, and subunits of enzymes with various redox functions. Unusual features included the absence of a Cdc6 homolog, implying a variation in replication initiation, and the presence of a bacterial-like RNase HI as well as an RNase HII typical of the Archaea. The presence of alanine dehydrogenase and alanine racemase, which are uniquely present among the Archaea, explained the ability of the organism to use L- and D-alanine as nitrogen sources. Features that contrasted with the related organism Methanocaldococcus jannaschii included the absence of inteins, even though close homologs of most intein-containing proteins were encoded. Although two-thirds of the ORFs had their highest Blastp hits in Methanocaldococcus jannaschii, lateral gene transfer or gene loss has apparently resulted in genes, which are often clustered, with top Blastp hits in more distantly related groups.
Arresting a Corpse (1918)

Arresting a Corpse Get access William F. Andrews William F. Andrews 1Hertford Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-IV, Issue 76, January 1918, Pages 28–29, https://doi.org/10.1093/nq/s12-IV.76.28h Published: 01 January 1918
Biosynthesis of dynemicin A, a 3-ene-1,5-diyne antitumor antibiotic (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of dynemicin A, a 3-ene-1,5-diyne antitumor antibioticYoshiyuki Tokiwa, Megumi Miyoshi-Saitoh, Hisayoshi Kobayashi, Rie Sunaga, Masataka Konishi, Toshikazu Oki, and Shigeo IwasakiCite this: J. Am. Chem. Soc. 1992, 114, 11, 4107–4110Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ja00037a011https://doi.org/10.1021/ja00037a011research-articleACS PublicationsRequest reuse permissionsArticle Views442Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dietary fiber and coronary heart disease (1990)

Facteurs de risques d'atherosclerose (lipides, alimentation, hypertension entre autres). Pathologie: mecanismes proposes de la pathologie de l'atherosclerose. Effets des fibres alimentaires sur les facteurs de risques. Revue des fibres alimentaires: gommes, pectine, fibres de cereales, de fruits, de legumineuse. Mecanismes d'actions des fibres. Applications therapeutiques. Revue bibliographique
Light-in-flight holographic particle image velocimetry for wind-tunnel applications (2004)

Holographic particle imaging techniques for air-flow investigations are mainly limited to small-scale laboratory experiments. The two main reasons are the limited light power available in conjunction with small tracer-particle sizes, which must be in the order of 1 µm to properly probe air flows, and the increased background noise from out-of-focus particles in deep volumes preventing investigations with higher particle densities. To ensure a good accuracy of the velocity measurements by faithful reconstruction geometry, the evaluation of particle images is often conducted in the original recording set-up. The time-consuming scanning process, however, blocks the flow facility during evaluation—a disadvantage for measurements in costly industrial wind tunnels. For an alternative, we have introduced off-site reconstruction and evaluation. In recent papers we have furthermore demonstrated principles to cope with little object light and to suppress background noise. Here we present a successful implementation of theses principles for wind-tunnel measurements.
Immunomodulation in Sepsis: State of the Art and Future Perspective (2010)

Despite advances in supportive care of critically ill patients, sepsis remains an important cause of death worldwide. More than 750,000 individuals develop severe sepsis in North America annually, with a mortality rate varying between 35 and 50%. Over recent years, numerous efforts have been committed to understanding the pathophysiology of septic syndrome, as well as attempts to intervene in the inflammatory cascade with the aim of altering the outcome of the syndrome and to improve survival. Not all of these attempts have been successful. Issued guidelines by the International Sepsis Forum have incorporated only the use of corticosteroids, tight glycemic control and the use of recombinant activated protein C as recommendations for the management of the septic patient along with the initial resuscitation and infection-site control measures. These strategies along, with novel attempts of immunomodulation, are thoroughly reviewed in this article.
Silicon Photonics Design (2015)

From design and simulation through to testing and fabrication, this hands-on introduction to silicon photonics engineering equips students with everything they need to begin creating foundry-ready designs. In-depth discussion of real-world issues and fabrication challenges ensures that students are fully equipped for careers in industry. Step-by-step tutorials, straightforward examples, and illustrative source code fragments guide students through every aspect of the design process, providing a practical framework for developing and refining key skills. Offering industry-ready expertise, the text supports existing PDKs for CMOS UV-lithography foundry services (OpSIS, ePIXfab, imec, LETI, IME and CMC) and the development of new kits for proprietary processes and clean-room based research. Accompanied by additional online resources to support students, this is the perfect learning package for senior undergraduate and graduate students studying silicon photonics design, and academic and industrial researchers involved in the development and manufacture of new silicon photonics systems.
A New Method For Active Noise Control Systems With Online Acoustic-Feedback-Path Modeling (2006)

This paper proposes a new method for online modeling of the acoustic feedback path in active noise control (ANC) systems. The proposed method comprises three adaptive filters: 1) the FxLMS algorithm based noise control filter, 2) a variable step size (VSS) LMS algorithm based feedback path modeling (FBPM) filter, and 3) LMS algorithm based adaptive noise cancellation (ADNC) filter. The ADNC filter removes the disturbance from the desired response of FBPM filter. The disturbance signal in FBPM filter is thus decreasing in nature, (ideally) converging to zero. This gives basic idea for the VSS LMS algorithm for FBPM filter: a small step size is used initially and later its value is increased accordingly. The computer simulations show that the proposed method can reduce FBPM error at a faster convergence rate than the existing methods
Improving the adequacy of Pap smears. (1989)

Several of the risk factors and pathophysiologic mechanisms for cervical carcinoma implicate the transformation zone of the cervix as the most important area for cytologic sampling. Improved screening can be achieved by ensuring that the transformation zone has been sampled, as evidenced by the number of endocervical cells on the smear. Use of the endocervical brush, combined with feedback from the laboratory about inadequate smears, may improve the technique for obtaining Pap smears.
Extremum-Seeking Control of a Mode-Locked Laser (2013)

An adaptive controller is demonstrated that is capable of both obtaining and maintaining high-energy, single-pulse states in a mode-locked fiber laser. In particular, a multi-parameter extremum-seeking control (ESC) algorithm is used on a nonlinear polarization rotation (NPR) based laser using waveplate and polarizer angles to achieve optimal passive mode-locking despite large disturbances to the system. The physically realizable objective function introduced divides the energy output by the kurtosis of the pulse spectrum, thus balancing the total energy with the coherence of the mode-locked solution. In addition, its peaks are high-energy mode-locked states that have a safety margin near parameter regimes where mode-locking breaks down or the multipulsing instability occurs. The ESC is demonstrated by numerical simulations of a single-NPR mode-locked laser and is able to track locally maximal mode-locked states despite significant disturbances to parameters such as the fiber birefringence.
Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12. (1996)

A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma and in hepatocellular carcinoma. In an effort to isolate the BRCA2 gene, we have cloned 73 non overlapping cDNAs from a set of nine YACs spanning 6 cM interval on chromosome 13q12 by using a direct cDNA selection method. One of the selected cDNAs corresponds to a region of the 3' portion of BRCA2 mRNA, the sequence of which was published recently (Wooster et al, 1995). Northern analysis of BRCA2 transcripts from a variety of cell lines showed altered sizes of the mRNA in a breast cancer cell line (MCF7) and a prostate carcinoma cell line (DU145). Furthermore, BRCA2 transcript was present in cDNA libraries from total fetus as well as adult human tissues. Fifteen unique cDNA fragments encode genes/ESTs that are already known, of which only two have been mapped to this region. The other 12 cDNAs include genes for RPL6/mRNA for TAX REB 107, elongation factor-1 delta, 26S protease S4 regulatory subunit, small cytoplasmic 7SL RNA, a full length open reading frame (ORFU), brain thiol specific antioxidant protein, ribosomal protein, L35, and lipoxygenase activating protein. Six cDNAs represent human homologs of genes known in other species, namely, mouse HSPE71, Rat RhoGAP protein, S cerevisiae leucyl tRNA synthetase and S cerevisiae chromosome II ORF YBLO44W. The remaining 52 cDNAs showed either weak similarity or no similarity to sequences in the nucleotide data base and hence would represent novel genes. The plausible functions of some of these genes based on their sequence similarity to other known genes is discussed.
Performance measurements of a superconductive microprobe for eddy current evaluation of subsurface flaws (1993)

First measurements of the performance of the superconductive microprobe show that its depth of field and resolution are far superior to those of conventional eddy-current probes. It is shown that the superconductive microprobe can detect millimeter-size flaws to depths of 5 mm in 2024 aluminum. It also easily detects a 1.4% loss in material owing to corrosion at the bond line of two 2.29-mm-thick, 7075 aluminum plates. The corrosion patch is 15.9 mm in diameter. The prototype shows three main limitations: standoff distance, electronic noise in the feedback circuitry, and interference from fluctuations in tilt while scanning a test surface. Decreasing the size of the pickup loops and source coil can decrease both the standoff distance and interference from tilt. Using digital circuitry can suppress the noise of feedback circuitry.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Performance evaluation of encryption techniques and uploading of encrypted data in cloud (2013)

Cloud computing is one of today's most exciting technologies due to its ability to reduce costs associated with computing while increasing flexibility and scalability for computer processes. Security is a foremost important issue for data in cloud. To look after the data from cloud data storage we store the encrypted data in cloud environment. For encrypting the data we use different types of encryption methods like RSA, SHA1, and MD5. Further we also measure the performance of the different encrypted techniques based on the Key size of each encrypted technique to upload data in to the cloud by providing the best way security to data.
Deduced amino‐acid sequence and possible catalytic residues of a novel pectate lyase from an alkaliphilic strain of <i>Bacillus</i> (2000)

The nucleotide sequence of the gene for a highly alkaline, low-molecular-mass pectate lyase (Pel-15) from an alkaliphilic Bacillus isolate was determined. It harbored an open reading frame of 672 bp encoding the mature enzyme of 197 amino acids with a predicted molecular mass of 20 924 Da. The deduced amino-acid sequence of the mature enzyme showed very low homology (< 20.4% identity) to those of known pectinolytic enzymes in the large pectate lyase superfamily (the polysaccharide lyase family 1). In an integrally conserved region designated the BF domain, Pel-15 showed a high degree of identity (40.5% to 79.4%) with pectate lyases in the polysaccharide lyase family 3, such as PelA, PelB, PelC, and PelD from Fusarium solani f. sp. pisi, PelB from Erwinia carotovora ssp. carotovora, PelI from E. chrysanthemi, and PelA from a Bacillus strain. By site-directed mutagenesis of the Pel-15 gene, we replaced Lys20 in the N-terminal region, Glu38, Lys41, Glu47, Asp63, His66, Trp78, Asp80, Glu83, Asp84, Lys89, Asp106, Lys107, Asp126, Lys129, and Arg132 in the BF domain, and Arg152, Tyr174, Lys182, and Lys185 in the C-terminal region of the enzyme individually with Ala and/or other amino acids. Consequently, some carboxylate and basic residues selected from Glu38, Asp63, Glu83, Asp106, Lys107, Lys129, and Arg132 were suggested to be involved in catalysis and/or calcium binding. We constructed a chimeric enzyme composed of Ala1 to Tyr105 of Pel-15 in the N-terminal regions, Asp133 to Arg159 of FsPelB in the internal regions, and Gln133 to Tyr197 of Pel-15 in the C-terminal regions. The substituted PelB segment could also express beta-elimination activity in the chimeric molecule, confirming that Pel-15 and PelB share a similar active-site topology.
Sodium channels from human brain RNA expressed in Xenopus oocytes. Basic electrophysiologic characteristics and their modification by diphenylhydantoin. (1989)

We describe the expression and characterization of sodium channels from human brain RNA in the Xenopus oocyte. The expressed channel, studied by whole-cell voltage clamp, reveals characteristic selectivity for sodium as the permeant ion, voltage-dependent gating, and block by nanomolar concentrations of tetrodotoxin. Such channels are not seen in control oocytes injected with solvent only. The anticonvulsant diphenylhydantoin (DPH) inhibits the expressed channel in a voltage- and use-dependent manner, much like the effect seen in primary mammalian neuronal preparations. The inhibition of the expressed human sodium channel by DPH can be described by models previously developed to explain block of Na channels by local anesthetics. The preferential block of Na channels during depolarization helps explain the selectivity of DPH for neurons involved in seizure activity.
Missense Mutations and Gene Interruption in <i>PROSIT240</i> , a Novel <i>TRAP240</i> -Like Gene, in Patients With Congenital Heart Defect (Transposition of the Great Arteries) (2003)

Together, these genetic data suggest that PROSIT240 is involved in early heart and brain development.
Intraocular tumor formation of RB reconstituted retinoblastoma cells. (1991)

It has been reported that replacement of a functional retinoblastoma (RB) gene in RB defective WERI-27 retinoblastoma cells results in complete loss of their tumorigenic potential in nude mice following s.c. injection. We have repeated the identical studies and found that although tumors did not develop s.c., the RB reconstituted cells, either soon after RB virus infection or after long term cultivation, consistently produced tumors when injected intraocularly. These tumor cells, when reestablished in culture, were found to retain a normal RB protein as determined by direct Western blotting and immunocytochemical staining. The tumors, however, occurred with a longer average latency period and with less frequency compared to those produced by the parental RB defective cells. Our results suggest that reintroduction of the RB gene into WERI-27 cells reduces but does not completely suppress their tumorigenic potential. Since retinoblastoma is an eye tumor it also provides further documentation that the use of an orthotopic injection site can be critical when determining the tumorigenicity of a given cell type.
Protection against Establishment of Retroviral Persistence by Vaccination with a Live Attenuated Virus (1999)

Many human viruses not only cause acute diseases but also establish persistent infections. Such persistent viruses can cause chronic diseases or can reactivate to cause acute diseases in AIDS patients or patients receiving immunosuppressive therapies. While the prevention of persistent infections is an important consideration in the design of modern vaccines, surprisingly little is known about this aspect of protection. In the current study, we tested the feasibility of vaccine prevention of retroviral persistence by using a Friend virus model that we recently developed. In this model, persistent virus can be detected at very low levels by immunosuppressing the host to reactivate virus or by transferring persistently infected spleen cells into highly susceptible mice. Two vaccines were analyzed, a recombinant vaccinia virus vector expressing Friend virus envelope protein and a live attenuated Friend virus. Both vaccines reduced pathogenic virus loads to levels undetectable by infectious center assays. However, only the live, attenuated vaccine prevented immunosuppression-induced reactivation of persistent virus. Thus, even very low levels of persistent Friend virus posed a significant threat during immunosuppression. Our results demonstrate that vaccine protection against establishment of retroviral persistence is attainable.