gebhart/patrepeval huggingface dataset:
Progesterone supplementation and the prevention of preterm birth. (2011)

Preterm birth is currently the most important problem in maternal-child health in the United States and possibly throughout the world. It complicates one in eight US deliveries, and accounts for over 85% of all perinatal morbidity and mortality. Although survival of preterm infants has increased steadily over the past four decades-due in large part to the use of antenatal corticosteroids, improvements in neonatal resuscitation, and the introduction of neonatal intensive care units-efforts to prevent preterm birth have been largely unsuccessful. On February 3, 2011, the US Food and Drug Administration (FDA) approved the use of progesterone supplementation (hydroxyprogesterone caproate) during pregnancy to reduce the risk of recurrent preterm birth in women with a history of at least one prior spontaneous preterm delivery. This is the first time that the FDA has approved a medication for the prevention of preterm birth, and represents the first approval of a drug specifically for use in pregnancy in almost 15 years. This article reviews the evidence behind the use of progesterone for the prevention of preterm birth, and provides guidelines for the use of progesterone supplementation in clinical practice. A number of areas of ongoing controversy are addressed, including the optimal formulation and route of administration, the safety of progesterone supplementation in pregnancy, and its proposed mode of action.
Hausa translation, cross-cultural adaptation, and assessment of psychometric properties of the motor activity log (2019)

Hausa version of MAL is valid and reliable at assessing real world arm use in stroke survivors.Implications for rehabilitationThe world is shifting towards Evidence Based Practice in the rehabilitation of conditions such as stroke.This entails selecting research backed treatment modalities, and tracking their efficacy using reputable outcome measures.However, these measures need to be valid for the particular population, culture or context.Consequently, the Hausa version of Motor activity log (MAL) can be used to assess real world arm use in stroke survivors who speak Hausa language.
Gas-Liquid Two Phase Flow Phenomenon In Near Horizontal Upward And Downward Inclined Pipe Orientations (2014)

The main purpose of this work is to experimentally investigate the effect of pipe orientation on two phase flow phenomenon. Flow pattern, void fraction and two phase pressure drop is measured in a polycarbonate pipe with an inside diameter of 12.7mm for inclination angles ranging from -20<sup>o</sup> to +20<sup>o</sup> using air-water fluid combination. The experimental data covers all flow patterns and the entire range of void fraction typically observed in two phase flow. The effect of pipe orientation on void fraction and two phase pressure drop is justified with reference to the change in flow structure and two phase flow behavior. In addition to this, the top performing void fraction and two phase pressure drop correlations available in the literature are presented and their performance is assessed against the experimental data in the present study and that available in the literature.
Clinical development of Taxol. (1993)

Taxol is the first of a novel class of anticancer drugs, the taxanes. Taxol's unique effects include its ability to polymerize tubulin into stable microtubules in the absence of cofactors and to induce the formation of stable microtubule bundles. During its development, formidable challenges were overcome: a suitable formulation was developed, an adequate supply was ensured, severe hypersensitivity reactions were diminished in incidence and severity, and clinical efficacy was demonstrated. Phase II evaluation is still underway; to date, clinical efficacy has been demonstrated in ovarian, breast, non-small-cell lung, and head and neck cancer. Response rates were low in early studies in melanoma, prostate, colon, cervix, and renal cancer, but for these tumors, additional evaluation is ongoing with a higher Taxol dose or different schedule. In December 1992, Food and Drug Administration approval was granted for use of Taxol as second-line therapy in ovarian cancer patients. Nevertheless, important questions regarding optimal use of this important new drug remain. These include determination of optimal dose and schedule and development of suitable combination chemotherapy regimens. The clinical development of Taxol and current status of phase I, II, and III clinical trials are reviewed.
MOO methods for multidisciplinary design using parallel evolutionary algorithms, game theory and hierarchical topology: theoretical aspects (part 1) (2012)

Two lecture notes describe recent developments of evolutionary multi objective optimization (MO) techniques in detail and their advantages and drawbacks compared to traditional deterministic optimisers. The role of Game Strategies (GS), such as Pareto, Nash or Stackelberg games as companions or pre-conditioners of Multi objective Optimizers is presented and discussed on simple mathematical functions in Part I , as well as their implementations on simple aeronautical model optimisation problems on the computer using a friendly design framework in Part II. Real life (robust) design applications dealing with UAVs systems or Civil Aircraft and using the EAs and Game Strategies combined material of Part I &amp; Part II are solved and discussed in Part III providing the designer new compromised solutions useful to digital aircraft design and manufacturing. Many details related to Lectures notes Part I, Part II and Part III can be found by the reader in [68].
Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating <i>Mycobacterium tuberculosis</i> (2007)

Screening for new antimicrobial agents is routinely conducted only against actively replicating bacteria. However, it is now widely accepted that a physiological state of nonreplicating persistence (NRP) is responsible for antimicrobial tolerance in many bacterial infections. In tuberculosis, the key to shortening the 6-month regimen lies in targeting this NRP subpopulation. Therefore, a high-throughput, luminescence-based low-oxygen-recovery assay (LORA) was developed to screen antimicrobial agents against NRP Mycobacterium tuberculosis. M. tuberculosis H37Rv containing a plasmid with an acetamidase promoter driving a bacterial luciferase gene was adapted to low oxygen conditions by extended culture in a fermentor with a 0.5 headspace ratio. The MICs of 31 established antimicrobial agents were determined in microplate cultures maintained under anaerobic conditions for 10 days and, for comparative purposes, under aerobic conditions for 7 days. Cultures exposed to drugs under anaerobic conditions followed by 28 h of "recovery" under ambient oxygen produced a luminescent signal that was, for most compounds, proportional to the number of CFU determined prior to the recovery phase. No agents targeting the cell wall were active against NRP M. tuberculosis, whereas drugs hitting other cellular targets had a range of activities. The calculated Z' factor was in the range of 0.58 to 0.84, indicating the suitability of the use of LORA for high-throughput assays. This LORA is sufficiently robust for use for primary high-throughput screening of compounds against NRP M. tuberculosis.
iSCAPS - Innovative Smart Car Park System integrated with NFC technology and e-Valet function (2013)

Innovative Smart Car Parking System (iSCAPS) integrated with e-Valet technology is proposed in this paper. The e-Valet function works just like how a valet parking would function. It ensures parking lot availability for the incoming customer. Beforehand, the smart phone is installed with the android apps to fully enjoy the functions of iSCAPS. By using the mobile apps, customer may reserve parking lot in advance, to enable the customer to park at a later time. Instead of using the conventional “Season Pass” or ticket, iSCAPS uses the Near Field Communication (NFC) function of smart phone as parking ticket. With the mobile apps, communication will occur when the smart phone is placed near the NFC reader. Therefore, customer only needs to tap the smart phone on the designated reader to enter the car park and tap again on the way out to complete payment. Arduino microcontroller is used as the brain of the system and control the input output of the system. Furthermore, vehicle searching function is included, which helps customers to locate their vehicle when forgotten. With the proposed iSCAPS the usage of RFID (Radio Frequency Identification) cards and paper tickets will be eliminated resulting lower cost, more convenience and eco-friendly.
Developing Cisco IP Phone Services : A Cisco AVVID Solution (2002)

Create applications that deliver interactive content to Cisco IP Phones Learn information and techniques vital to building and integrating third-party services for Cisco IP Phones Understand the development process using XML and HTTP client and server applications to successfully build a service Discover advanced services information about objects, advanced runtime generation, and other XML development tools Utilize the provided CallManager Simulator to support an IP phone for development purposesGet the most out of your IP phone systems with strategies and solutions direct from the Cisco teamServices on Cisco IP Phones help you enhance productivity, gain the competitive advantage, and even help generate revenue. Services are simply applications that run on the phone rather than on a PC or a web browser. By developing services tailored to your particular needs, you can achieve unlimited goals.Cisco AVVID IP Telephony provides an end-to-end voice-over-IP solution for enterprises. Part of that solution are Cisco IP Phones, a family of IP-based phones. Cisco IP Phones feature a large display, an XML micro browser capable of retrieving content from web servers, and the ability to deploy custom services tailored to your organization's or enterprise's needs.Developing Cisco IP Phone Services uses detailed code samples to explain the tools and processes used to develop custom phone services. You'll learn about XML, CallManager, Cisco IP Phones, and the history behind why Cisco chose XML to deploy phone services. You'll find detailed information to help you learn how to build a service, how to build a directory, and how to integrate your service with Cisco CallManager.This book complements and expands on the information provided in the Cisco IP Phone Services Software Developer's Kit (SDK). With the information in this book, you can maximize your productivity using the tools provided in the SDK and the custom tools provided on the companion CD-ROM. Beginner and advanced service developers alike benefit from the information in this book. Developing Cisco IP Phone Services represents the most comprehensive resource available for developing services for Cisco IP Phones.This book is part of the Cisco Press Networking Technologies Series, which offers networking professionals valuable information for constructing efficient networks, understanding new technologies, and building successful careers.
Development of Pop-Up Hood System for Pedestrian Protection (2013)

Pop-up hood systems have been developed as a pedestrian protection technology for vehicles that have a narrow space between the inside surface of the hood and the rigid parts in the engine compartment. The aim of these systems is to help reduce the head injury criterion (HIC) by lifting up the hood and creating a greater distance to the rigid parts in the engine compartment. However, various issues have yet to be resolved in the adoption of these systems. The first category of issues is sensing-related, such as the method of distinguishing between collisions with pedestrians and roadside objects, and ensuring stable detection regardless of the location of the collision at the front of the vehicle. The second category is actuator-related, particularly the method of keeping the hood held up while ensuring that the impact energy of the collision with the head is absorbed. This paper describes the development of a pressure chamber type sensing system and push-rod type actuator that were designed to address these issues.
Fundamental limits in chirped laser dispersion spectroscopy (2015)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Plant, A. Hangauer, and G. Wysocki, "Fundamental limits in chirped laser dispersion spectroscopy," in CLEO: 2015, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper SM1O.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
2009 Pandemic H1N1 Influenza Virus Replicates in Human Lung Tissues (2010)

The replication activity of 2009 pandemic H1N1 influenza virus in human lung cells was evaluated in this study. Twenty-two surgically removed human lung tissue samples were infected ex vivo with pandemic H1N1 influenza virus (A/California/04/2009), seasonal human H1N1 influenza virus (A/Shantou/92/09), or a highly pathogenic H5N1 influenza virus (A/Vietnam/1194/04). Examination of nucleoprotein expression and viral RNA replication in the infected human lung tissue samples showed that whereas the replication of pandemic H1N1 influenza virus varied between tissue samples, overall this virus replicated more efficiently than seasonal H1N1 influenza virus but less efficiently than H5N1 influenza virus. Double-immunostaining for viral antigens and cellular markers indicated that pandemic H1N1 influenza virus replicates in type 2 alveolar epithelial cells.
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO (2007)

The 8;21 translocation is a major contributor to acute myeloid leukemia (AML) of the M2 classification occurring in approximately 40% of these cases. Multiple mouse models using this fusion protein demonstrate that AML1-ETO requires secondary mutagenic events to promote leukemogenesis. Here, we show that the negative cell cycle regulator p21(WAF1) gene is up-regulated by AML1-ETO at the protein, RNA, and promoter levels. Retroviral transduction and hematopoietic cell transplantation experiments with p21(WAF1)-deficient cells show that AML1-ETO is able to promote leukemogenesis in the absence of p21(WAF1). Thus, loss of p21(WAF1) facilitates AML1-ETO-induced leukemogenesis, suggesting that mutagenic events in the p21(WAF1) pathway to bypass the growth inhibitory effect from AML1-ETO-induced p21(WAF1) expression can be a significant factor in AML1-ETO-associated acute myeloid leukemia.
Rapid large-scale preparation of recombinant Erwinia chrysanthemi L-asparaginase. (1992)

L-asparaginase from Erwinia provides an alternative to the enzyme from E. coli for the effective treatment of acute lymphoblastic leukaemia. A procedure was required for the large-scale partial purification of the recombinant Erwinia enzyme cloned and expressed in Erwinia. Enzyme was extracted from Erwinia at high pH and extraneous protein precipitated at low pH. S-Sepharose FF was selected as the medium of choice for the chromatography step since it was adequate for the high flow rates required (linear flow rate 315 cm h-1) and the methylsulphonate functional groups exploited the high pI of the enzyme by allowing binding of L-asparaginase at pH 4.8 while most of the other proteins passed through the column. The useful capacity of the matrix was up to 34 mg enzyme/ml matrix at a linear flow rate of 95 cm h-1 and 15.4 mg enzyme/ml matrix at a linear flow rate of 315 cm h-1. Weakly bound protein was removed by a wash at pH 6.0. The L-asparaginase was eluted by a wash at pH 6.8 (linear flow rate 95 cm h-1) and was substantially pure, only requiring polishing steps to be suitable for use as a parenteral agent. The purity of the protein was complemented by a 92% recovery of active enzyme from this cation-exchange matrix.
Iterative reconstruction of SPECT data with adaptive regularization (2002)

A nonlinear regularizing least-square reconstruction criterion is proposed for simultaneously estimating a single-photon emission computed tomography (SPECT) emission distribution corrected for attenuation together with its degree of regularization. Only a regularization trend has to be defined and tuned once for all on a reference study. Given this regularization trend, the precise regularization weight, which is usually fixed a priori, is automatically computed for each data set to adapt to the noise content of the data. We demonstrate that this adaptive process yields better results when the noise conditions change than when the regularization weight is kept constant. This adaptation is illustrated on simulated cardiac data for noise variations due to changes in the acquisition duration, background intensity, and attenuation map.
A simple ultrasonic ranging system (1983)

There are many instances in robot design where an inexpensive compact ranging system can be of great benefit. The system developed by a well-known camera company to automatically focus cameras is ideally suited to such applications. This system is composed of an electrostatic transducer and a single electronic module containing the drive, receiving, and processing circuitry. It can be used effectively to measure distance or detect the presence of objects within a range of 0.9–35 ft, operating at four discrete frequencies between 50 and 60 kHz. The system exhibits an acceptance angle of approximately 20°. To determine the distance to an object, the time interval between the transmit signal and the received echo must be externally determined. With an appropriate clock, a resolution of 0.25 in. can be obtained. Correction for changes in air temperature must be made to attain good resolution and accuracy throughout a wide temperature range. The system can therefore be used to map a robot's environment, or simply provide an effective means of collision avoidance.
A graph-based approach to skin mole matching incorporating template-normalized coordinates (2009)

Density of moles is a strong predictor of malignant melanoma. Some dermatologists advocate periodic full-body scan for high-risk patients. In current practice, physicians compare images taken at different time instances to recognize changes. There is an important clinical need to follow changes in the number of moles and their appearance (size, color, texture, shape) in images from two different times. In this paper, we propose a method for finding corresponding moles in patient's skin back images at different scanning times. At first, a template is defined for the human back to calculate the moles' normalized spatial coordinates. Next, matching moles across images is modeled as a graph matching problem and algebraic relations between nodes and edges in the graphs are induced in the matching cost function, which contains terms reflecting proximity regularization, angular agreement between mole pairs, and agreement between the moles' normalized coordinates calculated in the unwarped back template. We propose and discuss alternative approaches for evaluating the goodness of matching. We evaluate our method on a large set of synthetic data (hundreds of pairs) as well as 56 pairs of real dermatological images. Our proposed method compares favorably with the state-of-the-art.
Graphene/Polyaniline Nanocomposite for Hydrogen Sensing (2010)

Here we report on the synthesis of a graphene/polyaniline (PANI) nanocomposite and its application in the development of a hydrogen (H2) gas sensor. Using a chemical synthetic route, graphene was prepared and ultrasonicated with a mixture of aniline monomer and ammonium persulfate to form PANI on its surface. The developed material was characterized by scanning electron microscopy (SEM), transmission electron microscopy, Raman spectroscopy, and X-ray photoemission spectroscopy. The SEM study revealed that the PANI in the composite has a nanofibrillar morphology. We investigated the H2 gas sensing performance of this material and compare it with that of the sensors based on only graphene sheets and PANI nanofibers. We found that the graphene/PANI nanocomposite-based device sensitivity is 16.57% toward 1% of H2 gas, which is much larger than the sensitivities of sensors based on only graphene sheets and PANI nanofibers.
Degos disease associated with protein S deficiency (2005)

Journal Article Degos disease associated with protein S deficiency Get access Y. Gilaberte, Y. Gilaberte Departments of Dermatology, Haematology Search for other works by this author on: Oxford Academic Google Scholar C. Coscojuela, C. Coscojuela Departments of Dermatology, Haematology Search for other works by this author on: Oxford Academic Google Scholar A. Lezaún, A. Lezaún Departments of Dermatology, Haematology Search for other works by this author on: Oxford Academic Google Scholar M.A. Marigil M.A. Marigil Pathology, Hospital San Jorge, Avenue Martínez de Velasco 34, 22004 Huesca, Spain E‐mail: ygilaberte@salud.aragob.es Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 3, 1 September 2005, Pages 666–667, https://doi.org/10.1111/j.1365-2133.2005.06764.x Published: 01 September 2005
Multilayered vesicles prepared by reverse-phase evaporation: liposome structure and optimum solute entrapment (1987)

Liposome structure and solute entrapment in multilayered vesicles (MLVs) prepared by reverse-phase evaporation (REV) were studied. MLV-REV vesicles prepared from ether/water emulsions have high entrapment. Entrapment depends on drug, drug concentration, lipid, lipid concentration, and the container used to prepare the vesicles. By use of 300 microL of aqueous phase and 100 mg of phosphatidylcholine (PC), vesicles prepared in a test tube 25 mm X 175 mm have higher entrapment than vesicles prepared in a 100-mL round-bottom or pear-shaped flask. By use of a test tube, 100 mg of PC, and 300 microL of aqueous phase containing sucrose (1-50 mg/mL), greater than 90% sucrose entrapment was obtained. Increasing lipid content to 150 mg of PC decreased entrapment to approximately 80%. Neutral PC MLV-REV vesicles have optimum entrapment. Mixing negatively charged lipids or cholesterol (CH) with PC to make MLV-REV vesicles results in decreased entrapment compared to using only PC. Preparing vesicles with the solid lipid dipalmitoylphosphatidylcholine (DPPC) or DPPC/CH mixtures (0 less than or equal to mol % CH less than or equal to 50) results in approximately 30-40% entrapment when diethyl ether is used to make the MLV-REV emulsion. Substituting diisopropyl ether for diethyl ether and heating the MLV-REV emulsion during vesicle formation generate DPPC/CH vesicles that entrap 60% of added solutes. The high entrapment found for MLV vesicles prepared from water/organic solvent emulsions depends on maintaining a core during the process of liposome formation. A method to calculate the fraction of water residing in the liposomes' core is presented and used to compare multilayered vesicles prepared by different processes. X-ray diffraction data demonstrate that a heterogeneous distribution of lipid may exist in multilayered vesicles prepared by the REV process.