gebhart/patrepeval huggingface dataset:
Anticardiolipin antibodies in NZW x BXSB F1 mice. A model of antiphospholipid syndrome (1992)

NZW x BXSB F1 (W/B F1) male mice develop systemic lupus-like disease, and several autoantibodies, circulating immune complexes, and lupus nephritis become apparent. The abnormally high incidence of degenerative coronary vascular disease with myocardial infarction and thrombocytopenia due to the presence of both platelet-associated antibodies and circulating antiplatelet antibodies in this animal has been reported. We found that W/B F1 male mice produced autoantibodies against cardiolipin (aCL) and that the titer of aCL increases with age. aCL from W/B F1 male mice were mainly IgG and binding activity to cardiolipin was aCL-cofactor (beta 2-glycoprotein I (beta 2-GPI)) dependent. We developed monoclonal aCL from these animals and examined specificity of the autoantibodies. All the mAb used reacted with the negatively charged phospholipids, cardiolipin, phosphatidylserine, and phosphatidylinositol, and some reacted with platelets and DNA. The addition of human or mouse beta 2-GPI enhanced the titer for monoclonal aCL from the W/B F1 mice. From the results of competitive inhibition enzyme immunoassay with monoclonal aCL and purified beta 2-GPI, aCL from the W/B F1 mice recognized the complex of CL and beta 2-GPI. The W/B F1 male mouse may be an appropriate model for use in studies on the pathologic significance of aCL in patients with antiphospholipid syndrome.
Tugs, Stevedores, and the Warranty of Workmanlike Performance (1969)

And they had a knack of dying interesting deaths and uttering memorable last words."'The law of admiralty has developed more than its share of memorable words.Part of this results from status as a restricted specialty; for with a specialized bar, a knowledgable body of litigants, large amounts of money often at stake, concentration in a limited number of courts, and the special patronage of the United States Supreme Court, admiralty has proven to be a laboratory for judicial experimentation and innovation.Furthermore, admiralty cases present dramatic fact situations.It is a rare case that does not bring out just a little of the Joseph Conrad in the attorney writing the brief or the judge writing his opinion.Occasionally, these words develop a momentum of their own that outstrips the ideas that underlie them.This paper will be a study of a particular subspecialty of admiralty law-the liability relationship between a tug and its tow-in which momentum of the words "ex delicto" and that of "warranty of workmanlike performance" have recently led in two opposite directions.In one case the progression has been toward what is for admiralty a very conventional three-possibility tort-collision division of damages, and in the other, toward a more radical and artificial twopossibility contractual standard of indemnification for damage.Perhaps the root of the divergence lies in the fact that a tug-tow accident has elements of both contract and tort.The tug and tow owners begin with an implied or actual contractual relationship, while the tug tMember of the Ohio and Michigan Bars, associated with the firm of Arter, Hadden, Van Duzer, and Wycoff, Cleveland, Ohio; Visiting Professor of Law, Indiana University School of Law, (summer 1968).The opinions expressed in this article are not necessarily those of the author's firm or its clients.1. P. BLOOMFmLD, UNcommON PEOPLE 31 (1955), concerning the descendants of one Sir Henry Sidney, "[m]any of [whom] lived cultivated and full lives, even when these were somewhat abruptly brought to an end," but who, the writer admits, were to his knowledge otherwise unconnected with the towing business.
Determination of Drying Characteristics and Effective Diffusivity for Sugar Cubes (2004)

Abstract In this study, the drying characteristics of sugar cubes have been investigated. Drying experiments with sugar cubes were conducted in a laboratory‐type tray dryer at temperatures ranging from 45 to 95 °C and different air velocities (0.43, 0.56, and 0.7 m/s). Drying rates increased with the increase in temperature and air velocity. At high temperatures, the moisture content of the solid reached equilibrium moisture value in short time periods. Experimental data were analyzed by using the analytical solution of the unsteady‐state diffusion equation to determine the effective diffusivity in sugar cubes.
Discotic Twin and Triple Molecules with Charge-Transfer Interactions in Langmuir−Blodgett Films (1996)

X-ray and atomic force microscopy observations reveal features of the surface morphology of Langmuir−Blodgett (LB) films from discotic donor−acceptor molecules with strong core-to-core interactions caused by a charge-transfer (CT) complexation. The compounds are designed to be twin and triple molecules composed of chemically connected donor (triphenylene) and acceptor (trinitrofluorenone) fragments which display liquid crystalline structure in the bulk state. The LB films from these compounds possess edge-on orientation of molecules within monolayers with a smooth surface on a submicron scale but with substantial macroscopic imperfections. These imperfections are represented by the micron size fractures and ruptures apparently caused by local deformations and tensions during transfer of the discotic monolayers from the air−water interface to a solid substrate. It is suggested that this is due to the excessive rigidity of the monolayers caused by the stiffness of the columns with positional intracolumnar ordering enhanced by the strong intracolumnar CT interactions.
50. Some bromine-substituted derivatives of 8-hydroxyquinoline (1957)

H. Irving and A. R. Pinnington, J. Chem. Soc., 1957, 290 DOI: 10.1039/JR9570000290
Blockage of Tubular Epithelial to Myofibroblast Transition by Hepatocyte Growth Factor Prevents Renal Interstitial Fibrosis (2002)

Activation of alpha-smooth muscle actin-positive myofibroblast cells is a key event in the progression of chronic renal diseases that leads to end-stage renal failure. Although the origin of these myofibroblasts in the kidney remains uncertain, emerging evidence suggests that renal myofibroblasts may derive from tubular epithelial cells by a process of epithelial to mesenchymal transition. It was demonstrated that hepatocyte growth factor (HGF) exhibited a remarkable ability to block this phenotypic transition both in vitro and in vivo. HGF abrogated the alpha-smooth muscle actin expression and E-cadherin depression triggered by transforming growth factor-beta1 in tubular epithelial cells in a dose-dependent manner. HGF also blocked morphologic transformation of tubular epithelial cells and inhibited the expression and extracellular deposition of fibronectin. In a mouse model of renal fibrosis disease induced by unilateral ureteral obstruction, transforming growth factor-beta type I receptor expression was specifically increased in renal tubules, and myofibroblastically phenotypic transition of the tubules was evident in vivo. Remarkably, injections of exogenous HGF blocked myofibroblast activation and drastically prevented renal interstitial fibrosis in the obstructed kidneys. These results suggest that tubular epithelial to myofibroblast conversion may play an important role in the pathogenesis of renal fibrosis and that blocking this phenotypic transition could provide a novel therapeutic strategy for the treatment of fibrotic diseases.
Einfluß der Morphologie bei Polypropylen mit Propylen/Ethylen‐Copolymerisaten auf Tieftemperaturschlagzähigkeit und Weißbruch (1991)

Abstract Die reduzierte Schlagzähigkeit von Polypropylen unterhalb dessen Glasübergangstempertur kann durch Einmischen einer dispersen Phase verbessert werden. Mit dieser Zähigkeitsverbesserung geht aber durch die so erhöhte Craze‐Verformung die Bildung von Hohlräumen einher, an denen Licht gestreut wird; der aus optischen Gründen unerwünschte Weißbruch entsteht. Der Einfluß der Größe der dispergierten Teilchen auf die Tieftemperaturzähigkeit und die parallel laufende unerwünschte Neigung zum Weißbruch wird aufgezeigt.
Plane wave scattering from frequency-selective surfaces by the finite-element method (2002)

This paper presents the application of the finite-element method (FEM) to the analysis of reflection and transmission coefficients, effective permittivity, and permeability of periodic structures to incident plane waves. The problem domain is reduced to a unit cell by using linked boundary conditions (LBCs) and the accuracy and efficiency of the procedure is improved by using the scattered field formulation and perfectly matched layers (PMLs). Examples of the analysis of frequency-selective surfaces (FSSs) derived from photonic bandgap materials (PBGs) and composite materials with negative effective permeability and permittivity are presented.
Scaffold-Free <i>In Vitro</i> Arterial Mimetics: The Importance of Smooth Muscle–Endothelium Contact (2010)

We have developed an in vitro endothelial cell (EC)-smooth muscle cell (SMC) coculture platform that can mimic either the healthy or diseased state of blood vessels. Transforming growth factor-beta1 (TGF-beta1) and heparin were introduced to the SMC cultures to upregulate the SMC differentiation markers, alpha-smooth muscle actin (alpha-SMA) and calponin (homotypic model). Interestingly, seeding of near-confluent concentrations of ECs on the SMCs (heterotypic model) induced higher levels of alpha-SMA and calponin expression in the SMC cultures than did the addition of heparin and TGF-beta1 alone. The expression levels increased further on pretreating the SMCs with TGF-beta1 and heparin before adding a near-confluent monolayer of ECs. In contrast, seeding of sparse concentrations of ECs forced the SMCs into a more hyperplastic state as determined by alpha-SMA and calponin expression. This study highlights the importance of both soluble factors and EC seeding densities when considering culture conditions; in vivo SMCs are in close proximity with and interact with a monolayer of ECs. Our study suggests that this architecture is important for healthy vascular tissue function. In addition, it shows that disruption of this architecture can be used to mimic diseased states. As the EC-SMC coculture model can mimic either a diseased or a healthy blood vessel it may be useful as a test bed for evaluating cardiovascular therapeutics.
Trinocular stereo matching with composite disparity space image (2009)

In this paper we propose a method that smartly improves occlusion handling in stereo matching using trinocular stereo. The main idea is based on the assumption that any occluded region in a matched stereo pair (middle-left images) in general is not occluded in the opposite matched pair (middle-right images). Then two disparity space images (DSI) are merged in one composite DSI. The proposed integration differs from the known approach that uses a cumulative cost. The experimental results are evaluated on the Middlebury data set, showing high performance of the proposed algorithm especially in the occluded regions. Our method solves the problem on the base of a real matching cost, in such a way a global optimization problem is solved just once, and the resultant solution does not have to be corrected in the occluded regions. In contrast, the traditional methods that use two images approach have to complicate a lot their algorithms by additional add hog or heuristic techniques to reach competitive results in occluded regions.
Abstract 578: Hex is Essential for Cardiac Myogenesis in Differentiating Embryonic Stem Cells (2007)

Background: We previously demonstrated that Sox17, an Sry-box-containing transcription factor that interacts with the Wnt/ β-catenin pathway, is essential for cardiac myogenesis in differentiating embryonic stem (ES) cells. Sox17 shRNA blocks cardiac myogenesis and selectively impairs the induction of Hex, a member of the homeobox family of transcription factors, many of which are involved in developmental processes. However, whether Hex is a direct target of Sox17 or not and the function of Hex in mouse ES cell differentiation to cardiomyocytes have not been defined. Hypothesis: Hex is a direct target of Sox17, and Hex is essential for cardiac myogenesis in ES cells. Methods: Cells were subjected to lentiviral transduction for a chimeric protein, contains Sox17 fused to protein A, using a protocol that reconstructs the native Sox17 expression pattern. Protein A-TEV-tagged Chromatin Immuno-precipitation (PAT-ChIP) technology was used to purify the DNA fragments bound to Sox17. Chromatin-immunoprecipitated DNA was subjected to PCR for promoter regions of Hex that contain putative Sox-binding motifs. Lentiviral vectors encoding shRNAs that knock down Hex were transduced into AB2.2 cells. Transduced cells, distinguished by expression of EGFP, were flow-sorted and subjected to embryonic body (EB) culture. Total RNA was extracted from EBs at 10 time points. Real-time QRT-PCR was carried out for representative genes related to mesoderm formation, mesoderm patterning, and cardiac myogenesis. Spontaneously beating EBs were scored. Results: Several Hex promoter regions containing predicted Sox17 binding sites were confirmed as potential direct targets of Sox17. The prevalence of beating EBs and the expression of cardiogenic transcription factors (Nkx2.5, Tbx5, Mef2c, Gata4 and myocardin) and cardiac structural genes (Ryr2 and α-MHC) both were suppressed by Hex shRNA. Hex shRNA did not impair the progressive down-regulation of Sox2 and Oct4 (master regulators of pluripotency) or the induction of Brachyury/T and Mesp1/2 (markers of primitive and precardiac mesoderm, respectively). Conclusion: Hex is potentially a direct target of Sox17, and is essential for cardiac myogenesis in differentiating ES cells at the stage of cardiac specification.
Study of the Sintering of Glass (1949)

It has been shown experimentally that the mechanism of sintering of spherical glass particles is that of viscous flow. The viscosities of the investigated glass were determined for a range of temperatures from 575°C to 744°C. These viscosities remain in good agreement with those obtained by other methods.
Association of Gln222Arg polymorphism in the deoxyribonuclease I (DNase I) gene with myocardial infarction in Japanese patients (2006)

Our data demonstrate that Gln222Arg polymorphism in the DNase I gene is associated with MI in the Japanese patients.
Secretory production of human leptin inEscherichia coli (2000)

Human leptin is a 16 kDa (146 amino acids) protein secreted from adipocytes and influences body weight homeostasis. In this study, human leptin was produced and secreted efficiently in Escherichia coli using a novel Bacillus sp. endoxylanase signal peptide. The endoxylanase signal sequence consisted of 28 amino acids (84 bp) was fused to the leptin structural gene. The fused gene was expressed using an inducible promoter (T7 or Trc) by adding 1 mM IPTG. Using T7 promoter in E. coli BL21(DE3), most of protein produced was in a premature form. Using the Trc promoter, which is weaker than T7, leptin was efficiently produced and secreted as a mature form (40% of total proteins) at 37 degrees C. However, most of leptin (about 90%) formed the inclusion bodies in the periplasmic space of E. coli. At 30 degrees C, ca. 90% of leptin was produced in a soluble form, but the total amount of leptin produced was 40% less than that obtained at 37 degrees C. When the periplasmic oxidoreductase of E. coli, DsbA, was co-expressed, 69% of the secreted leptin (26% of total proteins) was produced as soluble form at 37 degrees C without the decrease of the amount of leptin produced.
Compressed air energy storage: Thermodynamic and economic review (2014)

Compressed air energy storage (CAES) is one of the most promising mature electrical energy storage (EES) technologies. In this paper, recent technological and thermodynamic advances in CAES are examined. This review includes an examination of the three major thermodynamic approaches to CAES, an overview of air and thermal storage systems, and an examination of CAES in a distributed application. An economic analysis is then offered in order to determine the commercial viability of this technology.
JOVENS INDÍGENAS DA ETNIA KANELA DO ARAGUAIA NA UNIVERSIDADE FEDERAL DE GOIÁS (UFG) (2022)

No Brasil existe um grande número de grupos étnicos de povos indígenas, apesar de o processo de colonização ter exterminado várias outras etnias. A etnia Kanela do Araguaia apresenta características distintas de outras etnias, devido ao seu contexto histórico de expulsão de suas terras e o seu deslocamento para outra região. Diante disso, esse artigo tem como objetivo compreender a inserção de jovens indígenas da etnia Kanela do Araguaia na Universidade Federal de Goiás (UFG), visando identificar as dificuldades enfrentadas por esses jovens no cenário acadêmico. Foram realizadas entrevistas com três acadêmicos indígenas da UFG dos Cursos de Enfermagem, Agronomia e Engenharia Elétrica. A pesquisa possibilitou dar voz aos acadêmicos indígenas que expressaram os seus anseios enquanto portadores do direito ao acesso a uma educação pública e de qualidade. Foi possível compreender através dos relatos que os entrevistados consideram uma grande conquista ingressar em uma universidade pública, no entanto ainda é um grande desafio para os indígenas tanto o ingresso quanto a permanência em uma instituição de ensino superior, dado o contexto de preconceito com esses povos e a dificuldade de inserção no meio, principalmente em relação à língua.
CloudAdvisor: A Recommendation-as-a-Service Platform for Cloud Configuration and Pricing (2013)

The proliferation of cloud computing can imply a barrier to cloud users. When deploying their complex workloads into clouds, cloud users are typically overwhelmed by too many technical choices. Moreover, underlying technologies and pricing mechanisms of clouds vary and are not transparent to them. Consequently, it is hard for cloud users to capture the monetary and performance implications of their workload deployments. This paper introduces a cloud recommendation platform, referred to as Cloud Advisor. It allows cloud users to explore various cloud configurations recommended based on user preferences such as budget, performance expectation, and energy saving for given workload. Then, it allows cloud users to compare offered price and performance with other clouds' offerings for the workload. By providing transparent comparisons, it can also support cloud provider to develop a competitive pricing strategy such as price reduction driven by energy efficiency. We have applied the proposed platform for recommendation from a real data center and some external clouds.
Multiple Order Diffractive Fresnel Lens (MOD-DFL) for Atmospheric Transit Surveying of Earthlike Exoplanets (2017)

A MOD-DFL is designed in the format of a large deployable space-based telescope for characterization of atmospheric content of potentially habitable exoplanets. Performance and function over a 1-2µm wavelength range is described.
Deuterium isotope effect in chloramphenicol action (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeuterium isotope effect in chloramphenicol actionEberhard Kutter and Hans MachleidtCite this: J. Med. Chem. 1971, 14, 10, 931–934Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jm00292a010https://doi.org/10.1021/jm00292a010research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Melanoma in black patients. (1982)

Melanoma in black patients is uncommon but not rare. This paper reports six cases seen in one general surgeon's practice in Arkansas during a 14-year period. A review of the current literature regarding melanoma in blacks is given.Characteristically, melanoma in blacks is found on the soles of the feet, palms of the hands, or mucous membranes. The tumor has a deadly potential unless it is treated at an early stage; four of the patients reported have died of metastatic disease. A public health program is needed to make physicians and the public aware of the incidence and location of this tumor.
Co‐expression of cytokeratin and vimentin intermediate filament proteins in benign and neoplastic breast epithelium (1989)

This paper identifies another neoplasm of epithelial origin which may express vimentin in addition to cytokeratins, thereby adding to the expanding list of tumours which demonstrate intermediate filaments (IFs) other than those of their reputed cell of origin. Twenty examples of benign breast disease and 66 carcinomas were examined for vimentin and cytokeratin IFs using an avidin-biotin-peroxidase complex technique. Co-expression of these IF proteins was found in 35 per cent of cases of benign breast tissue and in 60 per cent of the carcinomas. In 8 (16 per cent) of 50 cases of infiltrating ductal carcinoma, vimentin and cytokeratin immunostaining was observed in more than 60 per cent of the tumour cells. These carcinomas were predominantly of a high histological grade. In benign breast disease and well-differentiated carcinoma, vimentin was distributed in the basal and perinuclear regions of the cells, with sparing of the apical portions. In those cases in which large numbers of tumour cells expressed vimentin, cytoplasmic staining was diffuse, and often exhibited distinctive perinuclear and subplasmalemmal accentuation. We propose that a knowledge of the list of carcinomas which may co-express vimentin and cytokeratin IFs might be helpful in the assessment of undifferentiated tumours and metastatic deposits.
GroupCap: Group-Based Image Captioning with Structured Relevance and Diversity Constraints (2018)

Most image captioning models focus on one-line (single image) captioning, where the correlations like relevance and diversity among group images (e.g., within the same album or event) are simply neglected, resulting in less accurate and diverse captions. Recent works mainly consider imposing the diversity during the online inference only, which neglect the correlation among visual structures in offline training. In this paper, we propose a novel group-based image captioning scheme (termed GroupCap), which jointly models the structured relevance and diversity among group images towards an optimal collaborative captioning. In particular, we first propose a visual tree parser (VP-Tree) to construct the structured semantic correlations within individual images. Then, the relevance and diversity among images are well modeled by exploiting the correlations among their tree structures. Finally, such correlations are modeled as constraints and sent into the LSTM-based captioning generator. We adopt an end-to-end formulation to train the visual tree parser, the structured relevance and diversity constraints, as well as the LSTM based captioning model jointly. To facilitate quantitative evaluation, we further release two group captioning datasets derived from the MS-COCO benchmark, serving as the first of their kind. Quantitative results show that the proposed GroupCap model outperforms the state-of-the-art and alternative approaches.