gebhart/patrepeval huggingface dataset:
House debates waste export control bill (1989)

RETURN TO ISSUEPREVNewsNEXTHouse debates waste export control billDAVID HANSONCite this: Chem. Eng. News 1989, 67, 35, 23Publication Date (Print):August 28, 1989Publication History Published online10 November 2010Published inissue 28 August 1989https://pubs.acs.org/doi/10.1021/cen-v067n035.p023https://doi.org/10.1021/cen-v067n035.p023newsACS PublicationsCopyright © 1989 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Wastes Get e-Alerts
Vasculogenic impotence evaluated by high-resolution ultrasonography and pulsed Doppler spectrum analysis. (1985)

Vasculogenic impotence was evaluated by high-resolution sonography and quantitative Doppler spectrum analysis in 21 patients and two normal volunteers. Erection was induced by intracorporeal injection of papaverine, and B-scan imaging and Doppler analysis were performed with the penis flaccid and erect. The corpora cavernosa and its deep arteries, median septum, and corpus spongiosum were clearly displayed in every subject, with the dorsal vein and dorsal artery seen ventral to the corpora cavernosa. In the flaccid state, in all subjects, Doppler analysis demonstrated flow in the dorsal arteries but not in the deep arteries. During erection, the B-mode image showed varying degrees of enlargement of the corpora cavernosa, with increased tissue echogenicity, as well as a hypoechoic area in the peri-arterial region. The diameter of the penile arteries and flow within them also increased by varying degrees. Quantification of blood flow through all deep and dorsal arteries is feasible with this technique.
Electronic absorption spectroscopy and colour of chromium-doped solids (2002)

Twenty-one chromium-containing compounds and solid solutions belonging to ten structural types were obtained by either solid-state reactions or the Pechini method and studied from the point of view of the relationship between structure, composition and colour. Formation of single-phase products was assured by heating on several high-temperature stages and monitoring phase transformations by X-ray diffraction. Electronic absorption spectra and colour coordinates of the samples were obtained and analysed paying special attention to the dependence of the colour on the structural characteristics and the presence of chromium in oxidation states other than Cr(III).
ChemInform Abstract: Synthesis of Novel Substituted Pyridine Derivatives from 3,5‐Diacetyl‐2,6‐dimethylpyridine. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Novel Antithrombotic Role for High Molecular Weight Kininogen as Inhibitor of Plasminogen Activator Inhibitor-1 Function (2002)

The adhesive glycoprotein vitronectin (VN) forms a function-stabilizing complex with plasminogen activator inhibitor-1 (PAI-1), the major fibrinolysis inhibitor in both plasma and vessel wall connective tissue. VN also interacts with two-chain high molecular weight kininogen (HKa), particularly its His-Gly-Lys-rich domain 5, and both HKa and PAI-1 are antiadhesive factors that have been shown to compete for binding to VN. In this study the influence of HKa and domain 5 on the antifibrinolytic function of PAI-1 was investigated. In a purified system, HKa and particularly domain 5 inhibited the binding of PAI-1 to VN and promoted PAI-1 displacement from both isolated VN as well as subendothelial extracellular matrix-associated VN. The sequence Gly(486)-Lys(502) of HKa domain 5 was identified as responsible for this inhibition. Although having no direct effect on PAI-1 activity itself, HKa domain 5 or the peptide Gly(486)-Lys(502) markedly destabilized the VN.PAI-1 complex interaction, resulting in a significant reduction of PAI-1 inhibitory function on plasminogen activators, resembling the effect of VN antibodies that prevent stabilization of PAI-1. Furthermore, high affinity fibrin binding of PAI-1 in the presence of VN as well as the VN-dependent fibrin clot stabilization by the inhibitor were abrogated in the presence of the kininogen forms mentioned. Taken together, our data indicate that the peptide Gly(486)-Lys(502) derived from domain 5 of HKa serves to interfere with PAI-1 function. Based on these observations potential low molecular weight PAI-1 inhibitors could be designed for the use in therapeutic interventions against thromboembolic complications.
N-Heterocyclic Carbene Transfer from Gold(I) to Palladium(II) (2009)

N-Heterocyclic carbene gold(I) complexes [(L)AuCl] [L = 1,3-diethyl-4,5-dihydroimidazol-2-ylidene (3a); 1,3-dibenzyl-4,5-dihydroimidazol-2-ylidene (3c); 1,3-dipicolyl-4,5-dihydroimidazol-2-ylidene (3d); 1,3-diethylimidazol-2-ylidene (5a); and 1-methylthiomethyl-3-mesitylimidazol-2-ylidene (10)] react with [(PhCN)2PdCl2] to give the corresponding palladium complexes, and the reactions are promoted by the addition of triphenylphosphine. This study demonstrates that the carbene moiety can be transferred from Au(I) to Pd(II) for the first time.
Chemiluminescence in Autoxidation of Phosphonate Carbanions. Phospha-1,2-dioxetanes as the Most Likely High-Energy Intermediates (2003)

Autoxidation of the phosphonate carbanions derived from 9-phosphono-10-hydroacridanes provided chemiluminescence ascribed to the excited acridone anion. The intramolecular CIEEL (chemically initiated electron exchange luminescence) mechanism can be applied to this chemiluminescence because of the much higher emission efficiency compared to that of 9-phosphono-10-methylacridanes. The effect of the phosphonate substituents on the emission efficiency and especially on the rates of the chemiluminescence decay can be interpreted to originate from the valence deviation of the phosphorus atoms, which is connected with the substituent effect on the geometrical selectivity in the olefination reaction of the phosphonate carbanions. The enhanced chemiluminescence in the presence of the fluorophores was also detected in autoxidation of the carbanions of diethyl diphenylmethylphosphonate and fluorenylphosphonate. Although the evidence is circumstantial, these results strongly support the belief that phospha-1,2-dioxetane is the most likely high-energy intermediate generating the excited molecules.
Overexpression of p53 protein in a high-risk population of patients with superficial bladder cancer before and after bacillus Calmette-Guérin therapy: correlation to clinical outcome. (1996)

In this high-risk population of patients with superficial bladder tumors, patients who have p53 nuclear overexpression in the tumor and stage T1 disease before BCG therapy are at high risk of disease progression. Furthermore, in the group of patients with residual disease after BCG therapy, p53 status is a better predictor of disease progression than post-BCG stage.
Two-Pass End-to-End Speech Recognition (2019)

The requirements for many applications of state-of-the-art speech recognition systems include not only low word error rate (WER) but also low latency. Specifically, for many use-cases, the system must be able to decode utterances in a streaming fashion and faster than real-time. Recently, a streaming recurrent neural network transducer (RNN-T) end-to-end (E2E) model has shown to be a good candidate for on-device speech recognition, with improved WER and latency metrics compared to conventional on-device models [1]. However, this model still lags behind a large state-of-the-art conventional model in quality [2]. On the other hand, a non-streaming E2E Listen, Attend and Spell (LAS) model has shown comparable quality to large conventional models [3]. This work aims to bring the quality of an E2E streaming model closer to that of a conventional system by incorporating a LAS network as a second-pass component, while still abiding by latency constraints. Our proposed two-pass model achieves a 17%-22% relative reduction in WER compared to RNN-T alone and increases latency by a small fraction over RNN-T.
The Ultrastructural Organization and Architecture of Basement Membranes (1984)

Basement membranes are ubiquitous complex, multicomponent structures having diverse functions. They are morphologically distinct and exhibit specific structural details including the lamina rara and lamina densa. In addition, the interstitial stroma abutting the lamina densa has a unique organization. While the composition of basement membranes is still incompletely known, several components have been identified, including collagen types IV and V, laminin and heparan sulphate proteoglycan. High resolution immunoelectron microscopic studies have allowed the development of various models of the organization and architecture of the basement membrane, suggesting specific localizations of the various collagen types and specific domains of the collagen molecules, laminin and other components. In addition, high resolution metal shadow casting techniques have allowed the development of molecular models of specific components of the basement membrane and methods of studying the domain structure and interactions of these components.
ALEXITHYMIA COULD MASK DEPRESSION IN OBESE PATIENTS (2014)

Objective: This study aimed to evaluate the relationship between obesity, alexithymia (primary and secondary) and depression in a sample of obese outpatients. Methods: Among the patients referred to the outpatients’ clinic for obesity in a University Hospital, we consecutively enrolled 100 overweight/obese (BMI > 27 kg/m 2) subjects (35 males and 65 females) over a period of 20 months. Socio-demographic and clinical data were collected; all patients underwent the Toronto Alexithymia Scale (TAS-20) and the Center for Epidemiological Studies Depression Scale (CES-D) in order to measure alexithymia and depression. \nResults: The prevalence of alexithymia was 18% (25% including borderline values). TAS-20 mean score was 49.17 ± 12.38. Considering CES-D scores, 33% of the sample was possibly or probably depressed. CES-D score was significantly correlated to TAS-20 score (r = 0.393, p < 0.001), in particular with DIF (r = 0.524, p < 0.001) and DDF (r = 0.204, p < 0.05) subscales. BMI was not associated with alexithymia nor with depression. \nConclusion: Obesity determines a vulnerability in developing depression, therefore alexithymia in obese depressed patients could be an adaptive response (secondary alexithymia). Moreover alexithymia could lead the subjects to an underestimation of depression and to not seek a correct treatment.From our results, the multidisciplinary approach in treating obese subjects should include the evaluation of emotional aspects whose diagnosis can influence the course of treatment.
An Orthotopic Model for the Study of Growth Factors in the Ventral Prostate of the Rat: Effects of Epidermal Growth Factor and Basic Fibroblast Growth Factor (1994)

In order to determine if epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF) are capable of stimulating prostatic growth in situ, we complexed EGF and bFGF to a Matrigel (MG) vehicle that was subsequently injected orthotopically into the ventral prostate of adult rats. Three weeks following a single injection of 0.1 ng of EGF or bFGF, the wet weight of the growth factor-injected lobes of the ventral prostate was increased (P < or = 0.025) 144 +/- 14% and 138 +/- 8%, respectively compared to contralateral lobes injected with MG only. Total DNA and protein per lobe (P < or = 0.025) and the incorporation of bromodeoxyuridini (BrdUrd; P < or 0.01) were all significantly increased in lobes injected with EGF or bFGF compared to MG-injected lobes. Thus, EGF and bFGF were stimulating true growth of the rat ventral prostate in situ. The induced prostatic growth was ligand specific, because co-injection with neutralizing antibodies abolished EGF and bFGF stimulation of prostatic wet weight. The effect of a single injection of 0.1 ng of growth factor was long-lasting and elevated prostatic wet weight for 4 (P < or = 0.05; bFGF) to 6 (P < or = 0.05; EGF) weeks. Histologic evaluation did not reveal any gross changes in the ratio of stroma to epithelium in either EGF- or bFGF-injected lobes at the 0.1 ng/lobe dose. A slight hyperplasia of the prostatic epithelium was detected in lobes injected with 10 ng of EGF. Of note, the incorporation of BrdUrd was primarily localized in the luminal and basal epithelial cells, whereas incorporation into the prostatic stroma was scanty in lobes injected with either EGF or bFGF. In summary, we have developed an orthotopic model enabling the study of the roles of growth factors in prostatic physiology, function, and disease in situ. Additionally, we have demonstrated that when injected orthotopically into the rat ventral prostate, EGF and bFGF stimulate the growth of the prostatic epithelium to similar degrees.
Ubiquitination and Downregulation of BRCA1 by Ubiquitin-Conjugating Enzyme E2T Overexpression in Human Breast Cancer Cells (2009)

Breast cancer is generated through a multistep genetic and epigenetic process including activations of oncogenes and inactivations of tumor suppressor genes. Here, we report a critical role of ubiquitin-conjugating enzyme E2T (UBE2T), an E2 ubiquitin-conjugating enzyme, in mammary carcinogenesis. Immunocytochemical staining and in vitro binding assay revealed that UBE2T interacted and colocalized with the BRCA1/BRCA1-associated RING domain protein (BARD1) complex. Knocking down of UBE2T expression with small interfering RNA drastically suppressed the growth of breast cancer cells. Interestingly, in vivo ubiquitination assay indicated BRCA1 to be polyubiquitinated by incubation with wild-type UBE2T protein, but not with C86A-UBE2T protein, an E2 activity-dead mutant, in which the 86th residue of cysteine was replaced with alanine. Furthermore, knocking down of UBE2T protein induced upregulation of BRCA1 protein in breast cancer cells, whereas its overexpression caused the decrease of the BRCA1 protein. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex.
Hydrogen‐producing <scp><i>E</i></scp><i>scherichia coli</i> strains overexpressing lactose permease: <scp>FT</scp>‐<scp>IR</scp> analysis of the lactose‐induced stress (2013)

The lactose permease gene (lacY) was overexpressed in the septuple knockout mutant of Escherichia coli, previously engineered for hydrogen production from glucose. It was expected that raising the lactose transporter activity would elevate the intracellular lactose concentration, inactivate the lactose repressor, induce the lactose operon, and as a result stimulate overall lactose consumption and conversion. However, overexpression of the lactose transporter caused a considerable growth delay in the recombinant strain on lactose, resembling to some extent the "lactose killing" phenomenon. Therefore, the recombinant strain was subjected to selection on lactose-containing media. Selection on plates with 3% lactose yielded a strain with a decreased content of the recombinant plasmid but with an improved ability to grow and produce hydrogen on lactose. Macromolecular analysis of its biomass by means of Fourier transform-infrared spectroscopy demonstrated that increase of the cellular polysaccharide content might contribute to the adaptation of E. coli to lactose stress.
Fluorescence detection in Lab-on-a-chip systems using ultrafast nucleic acid amplification methods (2014)

Today, nucleic amplification plays a key role in modern molecular biology allowing fast and specific laboratory diagnostics testing. An ultrafast microfluidic module (allowing 30 polymeric chain reaction (PCR) cycles in 6 minutes) based on an oscillating fluid plug concept was previously developed[1]. This system allows the amplification of native genomic deoxyribonucleic acid molecules (DNA) even from whole blood samples but still lacks some functionality compared to commercial bench top systems. This work presents the actual status of the renewed and advanced system, permitting the automated optical detection of not only the fluid plug position but also fluorescence detection. The system uses light emitting diodes (LED) for illumination and a low cost CMOS web-camera for optical detection. Image data processing allows the automated process control of the overall system components. Therefore, the system enables the performance of rapid and robust nucleic acid amplifications together with the integration of real time measurement technology. This allows the amplification and simultaneous quantification of the DNA molecules. The possibility to integrate swift nucleic amplification and optical detection into complex sample-to-answer analysis platforms opens up new pathways towards fast and transportable low-cost point of care devices.
Three-Component Coupling of Arynes, Aminosilanes, and Aldehydes (2007)

A three-component coupling of arynes, aminosilanes, and aldehydes enables diverse amino and hydroxymethyl groups to be incorporated directly into 1,2-positions of aromatic rings.
Nonlinear ΔR effects in perfusion quantification using bolus‐tracking MRI (2009)

Dynamic susceptibility contrast MRI involves injection of a contrast agent, whose concentration is estimated from DeltaR*2 changes. However, measurement of contrast-agent concentration is prone to various sources of error; in particular, the commonly assumed linear relationship between contrast agent concentration and DeltaR*2 in arterial blood is known to be invalid. In this study, we characterized the associated perfusion errors. Large errors were found when the linear assumption is used; these errors were highly dependent on the choice of tissue relaxivity. The errors were greatly reduced when using the quadratic model, and were further reduced when quantifying perfusion as a relative measure. This study suggests the linear assumption should be abandoned in favor of the quadratic model. Thus, the errors are minimized leading to improved quantification that will enable perfusion MRI to continue to play an important role in quantifying perfusion in brain diseases (e.g., acute stroke).
Measurement of a health index for Li-Ion batteries (2013)

Energy independence, reduction of CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> emissions and increasing oil prices are the key drivers for the development of new transportation technologies, among which the Battery Electric Vehicles. Instead of representing merely a load, they can provide ancillary services to the power grid: such integration of vehicles into the grid is known as V2G. The continuous charging and discharging of the batteries to provide services to the grid tends to degrade the vehicle batteries, decreasing their maximum life. Therefore it is of interest developing a management strategy that tends to maximize the life of the batteries. To this end it is of fundamental importance being able to assess the state of health of a battery. In this paper a methodology for the measurement of the health is described, and the first experimental results are provided.
Titanium complexes with imidazolin-2-iminato ligands (2004)

The reaction of 1,3-di-tert-butylimidazolin-2-ylidene with trimethylsilyl azide furnishes the corresponding N-silylated 2-iminoimidazoline which reacts with titanium(IV) chlorides to yield imidazolin-2-iminato titanium complexes.
Expression of the C‐<i>erb</i>B‐3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1 (1993)

We have examined the expression of the c-erbB-3 protein in a wide range of tumours of the gastrointestinal (GI) tract using immunocytochemical staining. Two antibodies were employed, a polyclonal antibody, 49.3, and a new monoclonal antibody, RTJ1, both raised to a synthetic peptide from the cytoplasmic domain of the human c-erbB-3 protein. The antibodies recognize c-erbB-3 by immunoprecipitation and Western blotting of lysate prepared from a cell line engineered to overexpress the protein. Both antibodies also detect expression of the protein in formalin-fixed, paraffin-embedded human tissues. The RTJ1 monoclonal antibody gave superior staining, showing lower background and more pronounced cell surface immunoreactivity. The c-erbB-3 protein was found in normal epithelial cells throughout the GI tract, in squamous epithelium of the oropharanyx and oesophagus, in the parietal cells of the stomach, and in the surface enterocytes of the small and large bowel. Seventy-six tumours arising at these sites were examined for c-erbB-3 protein expression. Widely varying levels of expression were seen, from absent to intense staining with cell membrane accentuation.
Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs (1997)

Resistant virus was isolated from virus propagated in cell culture in the presence of the human immunodeficiency virus type 1 (HIV-1) proteinase inhibitor DMP 323, Ro 31-8959, or A-75925. The proteinase gene of resistant virus was sequenced, and key mutations (G48V, V82A, I84V, L90M, and G48V/L90M) were introduced into clones used for the expression, purification, and further characterization of the enzyme. The mutant enzymes were all less active than the wild-type enzyme, as judged by k(cat) and k(cat)/Km values. L90M had a lower Km than the wild type, whereas the G48V/L90M double mutant had an increased Km compared with that of the wild type, contributing to a 10-fold reduction in the k(cat)/Km. Vitality values were used to show that the enzyme of the I84V mutant is the enzyme most resistant to the two cyclic urea inhibitors DMP 323 and AHA 008. Virus with the same mutation is also resistant, although the double mutation L10F/I84V confers even greater resistance. All of these mutants are more resistant to DMP 323 than to AHA 008. The resistance of the I84V mutant may be attributed to a loss of van der Waals interactions with the inhibitor, since the larger amino acid side chain involved in the interaction is replaced by a smaller side chain. This is supported by the lower level of resistance to AHA 008 that was observed. The phenyl groups of AHA 008 should protrude deeper into the S1 and S1' subsites than those of the smaller compound DMP 323, reducing the loss of interaction energy. These results reveal that small structural modifications of inhibitors that do not affect the inhibitory effect on wild-type virus can influence the inhibition of resistant strains. This is of importance for optimizing drugs with respect to their potency and resistance.