gebhart/patrepeval huggingface dataset:
Improved cadaverine production from mutant <i>Klebsiella oxytoca</i> lysine decarboxylase (2015)

Cadaverine has the potential to become an important platform chemical for the production of nylon. Previously, a system that overexpresses the Klebsiella oxytoca lysine decarboxylase in Escherichia coli was engineered. The system was optimized by codon optimization, and tuning the expression level of the gene by testing various promoters and inducer concentrations. Here, we further improved the system by optimizing the sequence located in the region of the ribosome‐binding site in order to enhance translation efficiency. We also identified mutant lysine decarboxylase enzymes that demonstrated enhanced cadaverine‐production ability. Together, these modifications increased cadaverine production in the system by 50%, and the system has a yield of 80% from lysine‐HCl under the conditions we tested. This is the first time that a system to produce cadaverine using the lysine decarboxylase from K. oxytoca performed at a level that is competitive with the traditional systems using the E. coli lysine decarboxylases in both lab‐scale and batch fermentation conditions.
High Field Effect Mobility in 6H-SiC MOSFET with Gate Oxides Grown in Alumina Environment (2005)

Lateral inversion channel metal-oxide-semiconductor field-effect transistors (MOSFETs) were manufactured on 6H-SiC and two gate oxidation recipes were compared. In one case the gate oxide was grown in N2O using quartz environment. The resulting peak field-effect mobility was µFE=43 cm2/Vs. In the other case the gate oxide was grown in oxygen using alumina environment and the resulting peak field-effect mobility was µFE=130 cm2/Vs. Oxidizing in an environment made from sintered alumina introduces contaminants into the oxide that effect the oxidation in several^ways. The oxidation rate is increased and the resulting SiC/SiO2 interface allows higher inversion channel mobility.
SELF-STARTING, INTRINSICALLY CONTROLLED STIRLING ENGINE (1976)

The engine is a four-displacer, four-power piston, horizontally opposed, offset (gamma type) machine uses four hypocycloid gear sets to couple the two oscillating displacer shafts and the two oscillating power piston shafts with the rotating output shaft. A spur gear phase changer is used at any time to change the phase angle between the displacers and the power pistons to control torque. This engine appears to be ideal for powering vehicle since it self-starts and has built-in torque control, reverse, and regenerative braking. It can be permanently connected to a thermal energy storage (TES) reservoir because of its very low heat leak when not in used. An engine and TES conceptual design and performance prediction is given for a small car power plant.
Seed desiccation tolerance and storability: Dependence on flatulence-producing oligosaccharides and cyclitols—review and survey (1994)

Abstract Stachyose, raffinose and related flatulence-producing oligosaccharides (α-galactosyl derivatives of sucrose) are associated with desiccation tolerance and storability of seed germplasm. Orthodox seeds of species with a sucrose-to-oligosaccharide ratio of <1.0 have storability half-viability periods >10 years while those >1.0 have a storability half-viability period <10 years. Seeds vary in their composition of oligosaccharides and some accumulate α-galactosyl derivatives of cyclitols. Known and proposed pathways for biosynthesis of soluble oligosaccharides, cyclitols and galactosyl derivatives of cyclitols are presented. Axes, cotyledons, embryos or seeds of 19 species in 7 families (all orthodox seeds) were analysed for sucrose, galactosyl derivatives of sucrose, cyclitols and galactosyl derivatives of cyclitols by high resolution gas chromatography. Sucrose and myo -inositol are universally present and galactinol is present in seeds accumulating stachyose series oligosaccharides. Seeds of some species of Leguminosae accumulate mostly stachyose series oligosaccharides, whereas seeds of other species accumulate varying levels of galactosyl derivatives of cyclitols in addition. Castor bean (Euphorbiaceae) seeds accumulate galactinol and buckwheat (Polygonaceae) embryos accumulate galacto- chiro -inositol instead of the stachyose series oligosaccharides. The mass ratio of sucrose:non-sucrose is related to storability and is applicable to seeds accumulating cyclitol derivatives. Galactinol and galacto- chiro -inositol are proposed to function in the same role as raffinose and stachyose in facilitating desiccation tolerance and storability.
MR diffusion-weighted imaging in a case of West Nile virus encephalitis (2003)

<b>573</b> <h3><b>Objectives</b></h3> HCC patients meeting Milan criteria (MC) have a good 5-year disease-free survival (DFS). We investigate whether MC assessed by dual-tracer (<sup>11</sup>C-acetate: ACT & <sup>18</sup>F-FDG) PET/CT could predict 5-year DFS for liver transplant (LT) candidates with HCC. <h3><b>Methods</b></h3> From year 2008, LT candidates with pre/post-operative dual-tracer PET/CT and contrast CT were recruited. They underwent either hepatectomy or LT post imaging evaluation and were followed for 5 years or till HCC recurrence. Preoperative dual-tracer PET/CT and contrast CT were reviewed independently based on the parameters (tumor size and extent, vascular invasion and metastasis) specified by MC with postoperative pathology as the gold standard. For prediction of HCC recurrence within 5 years, KM univariate analysis was performed on the following parameters: age, assessment of MC individually by CT and by dual-tracer PET/CT, primary HCC purely-avid-for-ACT, surgical treatment with hepatectomy or LT. The independent predictors for 5-year DFS were further analyzed by multivariate Cox regression. <h3><b>Results</b></h3> 22 LT candidates (M:18, F:4; mean age=56±9.3y; 21 HBV, 1 HCV) were included (lesion size:1.4~7 cm, ≤3 lesions/patient). Pathological assessment classified 14 patients within and 8 beyond MC. The assessment of MC by dual-tracer PET/CT was significantly better than contrast CT in correlation with pathology (correlation=0.904 vs 0.174). 9/22 patients had recurrent HCC within 5 years. Univariate analysis identified 2 significant predictors for a better 5-year DFS: 1. assessed by dual-tracer PET/CT as meeting MC (median DFS>5 y vs 22 mo for those beyond MC); 2. primary HCC being purely ACT-avid (median DFS>5 y vs 26 mo for those with <sup>18</sup>F-FDG-avidity, both P<0.05). Both parameters were also independent predictors for 5-year DFS by multivariate analysis. <h3><b>Conclusions</b></h3> Preoperative dual-tracer PET/CT is more accurate than contrast CT for evaluation of MC for LT candidates. HCC patients satisfying MC based on dual-tracer PET/CT assessment and with pure ACT-avidity have a better 5-year DFS.
On the overestimation of early wall thickening at the carotid bulb by black blood MRI, with implications for coronary and vulnerable plaque imaging (2008)

Black blood MRI is an attractive tool for monitoring normal and pathological wall thickening; however, limited spatial resolutions can conspire with complex vascular geometries to distort the appearance of the wall in ways hitherto unclear. To elucidate this, a thin-walled cylinder model was developed to predict the composite effects of obliqueness, in-plane resolution and voxel anisotropy on the accuracy of MRI-derived wall thickness measurements. These predictions were validated by means of imaging of a thin-walled carotid bifurcation phantom. Typical thick-slice axial acquisitions were found to result in artifactual wall thickening at the carotid bulb, owing to its obliqueness to the nominal imaging plane. Obliqueness was less problematic for near-isotropic resolutions; however, the obligatory reduction of in-plane resolution served to inflate wall thicknesses uniformly by up to 50%. Moreover, the nonlinear relationship between wall thickness and its overestimation served to mask genuine differences in wall thickness, an effect predicted to be worse for thinner coronary artery walls and plaque caps. Therefore, care must be taken when interpreting black blood MRI wall thickness measurements in the presence-or absence-of observed differences within or between individuals.
A comparison of sensors for minimizing the primary signal in planar-array magnetic induction tomography (2005)

In magnetic induction tomography reducing the influence of the primary excitation field on the sensors can provide a significant improvement in SNR and/or allow the operating frequency to be reduced. For the purposes of imaging, it would be valuable if all, or a useful subset, of the detection coils could be rendered insensitive to the primary field for any excitation coil activated. Suitable schemes which have been previously suggested include the use of axial gradiometers and coil-orientation methods (Bx sensors). This paper examines the relative performance of each method through computer simulation of the sensitivity profiles produced by a single sensor, and comparison of reconstructed images produced by sensor arrays. A finite-difference model was used to determine the sensitivity profiles obtained with each type of sensor arrangement. The modelled volume was a cuboid of dimensions 50 cmx50 cmx12 cm with a uniform conductivity of 1 S m-1. The excitation coils were of 5 cm diameter and the detection coils of 5 mm diameter. The Bx sensors provided greater sensitivity than the axial gradiometers at all depths, other than on the surface layer of the volume. Images produced using a single-planar array were found to contain distortion which was reduced by the addition of a second array.
Reactions of Nitrones with Free Radicals. II. Formation of Nitroxides (1970)

Abstract Reactions of N-t-butylaldonitrones with free radicals gave stable nitroxides, one of which was isolated in pure state. The stability of the nitroxides was explained by the steric effect around the nitrogen and α-carbon atoms. In the reaction of 5,5-dimethyl-Δ1-pyrroline N-oxide with AIBN, nitroxide was detected by ESR technique, and 1,3-adduct and ketonitrone were isolated from the reaction mixture. From the results, it was confirmed that nitroxide is the intermediate of the 1,3-adduct formation and that a radical first adds to the carbon atom and then adds to the oxygen atom of the nitrones.
C1-Methylated 5-hydroxy-2-(dipropylamino)tetralins: central dopamine-receptor stimulating activity (1984)

C1-Methylated derivatives of the potent dopaminergic agonist 5-hydroxy-2-(di-n-propylamino)tetralin (6) have been synthesized and tested for central dopamine (DA) receptor stimulating activity, by using biochemical and behavioral tests in rats. Both cis- and trans-5-hydroxy-1-methyl-2-(di-n-propylamino) tetralin (4 and 3) may be classified as central DA-receptor agonists, albeit of lower potency than 6. The results obtained indicate that both 4 and 3 display DA-autoreceptor stimulation capacity. However, only one of the isomers, trans-3, is able to elicit clear-cut postsynaptic DA receptor agonist actions at larger doses. 5-Hydroxy-1,1-dimethyl-2-(n-propylamino) tetralin (5) was found to be inactive.
Liquid Chromatographic Determination of Sulfentrazone in Soil (1999)

Abstract A rapid method for the determination of sulfentrazone in soils is described. The method consists of extraction of soil samples with methanol, filtration, liquid chromatographic separation of methanol-soluble components through a C18 column, and ultraviolet detection at 220 nm. Recoveries from fortified surface soils were &gt;85% for sulfentrazone. Average relative standard deviations over the soils examined was 7.7%. A conservative lower limit of quantitation for sulfentrazone was 40 ng/g soil.
Contents (2018)

This book critically examines the range of policies and programmes that attempt to manage economic activity that contributes to political violence. Beginning with an overview of over a dozen policies aimed at transforming these activities into economic relationships which support peace, not war, the book then offers a sustained critique of the reasons for limited success in this policy field. The inability of the range of international actors involved in this policy area, the Development-Security Industry (DSI), to bring about more peaceful political-economic relationships is shown to be a result of liberal biases, resulting conceptual lenses and operational tendencies within this industry. A detailed case study of responses to organised crime in Kosovo offers an in-depth exploration of these problems, but also highlights opportunities for policy innovation. This book offers a new framework for understanding both the problem of economic activity that accompanies and sometimes facilitates violence and programmes aimed at managing these forms of economic activity. Summaries of key arguments and frameworks, found within each chapter, provide accessible templates for both students and aid practitioners seeking to understand war economies and policy reactions in a range of other contexts. It also offers insight into how to alter and improve policy responses in other cases. As such, the book is accessible to a range of readers, including students interested in peace, conflict and international development as well as policy makers and practitioners seeking new ways of understanding war economies and improving responses to them.
Effect of inclusion level of linseed on the nutrient utilisation of diets for growing broiler chickens (2001)

1. Diets containing linseed at inclusions of 0, 80, 120 and 160 g/kg were evaluated for digestibility of nutrients and AMEn content with male broiler chickens. 2. Increasing the concentration of linseed decreased the retention of nitrogen and the digestibility of amino acids, crude fat and fatty acids of diets. 3. Dietary AMEn (MJ/kg) was also affected by the rate of inclusion of linseed, values decreasing from 14.39 to 12.49. 4. In general, a linear regression model explained the relationship between dietary linseed content and nutritive parameters. However, the quadratic response found for the digestibility of several amino acids and fatty acids indicated a non-additive change in their digestibility. 5. Viscosity ofjejunal digesta was markedly increased by each increment of linseed in the diets. This is attributable to the presence of mucilage in linseed and it might explain many of the results obtained in this study.
Supply concept in input powered two channel switch (2010)

This paper presents a supply concept for a two channel low side switch. The circuit is supplied from the input pins, each input supplying the corresponding channel. The topology presented in this paper selects the highest input voltage to supply common blocks. Simulations are used to observe the behavior of the switch.
Condensations by Sodium. VIII. Solvent Exchange Reactions, Preparation of Phenylmalonic Acid, and Comments on Some Mechanisms of Reactions which Employ Sodium (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensations by Sodium. VIII. Solvent Exchange Reactions, Preparation of Phenylmalonic Acid, and Comments on Some Mechanisms of Reactions which Employ SodiumAvery A. Morton and Ingenuin HechenbleiknerCite this: J. Am. Chem. Soc. 1936, 58, 12, 2599–2605Publication Date (Print):December 1, 1936Publication History Published online1 May 2002Published inissue 1 December 1936https://pubs.acs.org/doi/10.1021/ja01303a063https://doi.org/10.1021/ja01303a063research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Polymorphism of SSR markers in several wheat cultivars with high resistance to pre-harvest sprouting (2003)

To selected parents in constructing mapping population,32 SSR markers were used to analyze 10 wheat cultivars,which included 7 pre-harvests sprouting resistant cultivars and 3 pre-harvest sprouting cultivars.The results showed 75?% polymorphism were tested.The cluster analysis indicated that there was highly genetic similarity among the pre-harvest sprouting resistant wheat cultivars except SK2.Three cross,SK2×SFY2,CANK×SFY3,AUSK×SFY3,were selected to construct genetic map.
Complementation by <i>BCL2</i> and C-HA-<i>RAS</i> Oncogenes in Malignant Transformation of Rat Embryo Fibroblasts (1990)

The BCL2 (B cell lymphoma/leukemia-2) and C-HA-RAS oncogenes encode membrane-associated proteins of 26 and 21 kilodaltons, respectively. Although RAS proteins have long been known for their ability to bind and hydrolyze GTP, recent investigations suggest that BCL2 encodes a novel GTP-binding protein (S. Haldar, C. Beatty, Y. Tsujimoto, and C. M. Croce, Nature [London] 342:195-198, 1989). Cotransfection of BCL2 and HA-RAS oncogenes resulted in morphological transformation of early-passage rodent fibroblasts, rendering these cells tumorigenic in animals and enabling them to grow in semisolid medium. In contrast, cotransfection of BCL2 with oncogenes that encode nuclear proteins (E1A and C-MYC) did not produce malignant transformation, whereas HA-RAS did complement with these genes. These findings suggest that proteins encoded by oncogenes such as BCL2 and HA-RAS, although having similar subcellular locations and perhaps similar biochemical properties, can regulate distinct complementary pathways involved in cellular transformation.
On the use of look-up tables in the microprocessor implementation of digital filters (1983)

Abstract A simple method is proposed, which results in a 60% reduction in the time taken to obtain a product from a look-up table. This corresponds to increased bandwidths of digital filters implemented using a microprocessor.
The biocleavage of alkyl glyceryl ethers in Morris hepatomas and other transplantable neoplasms. (1970)

This study compares the ether-cleaving ability of normal rat liver homogenate with various transplantable tumor homogenates. The results show that the cleavage system is the most active in normal rat liver and Morris Hepatoma 7794A, much less active in Hepatoma 7777, and very low or absent in the other tumors tested. These data demonstrate that neoplasms that contain high levels of O -alkyl-diacylglycerols do not have an active alkyl ether cleavage system.
Review: <i>Netherlands India: A Study of Plural Economy</i>, by J. S. Furnivall (1940)

Book Review| March 01 1940 Review: Netherlands India: A Study of Plural Economy, by J. S. Furnivall Netherlands India: A Study of Plural EconomyJ. S. Furnivall John L. Christian John L. Christian Search for other works by this author on: This Site PubMed Google Scholar Pacific Historical Review (1940) 9 (1): 91–93. https://doi.org/10.2307/3634143 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation John L. Christian; Review: Netherlands India: A Study of Plural Economy, by J. S. Furnivall. Pacific Historical Review 1 March 1940; 9 (1): 91–93. doi: https://doi.org/10.2307/3634143 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentPacific Historical Review Search This content is only available via PDF. Copyright 1940 The Pacific Coast Branch, American Historical Association Article PDF first page preview Close Modal You do not currently have access to this content.
Program window of doped Sb2Te phase change line cells (2007)

The magnitude of the reset current of doped Sb2Te line cells is determined. The lowest measured reset current is 280μA. It is shown that the larger part of the program energy flows into the surrounding dielectric of the line. Extrapolation of the results in a scaling scenario reveals that a minimum reset current of 50μA can be achieved using a supply voltage of 1.2V. The set voltage is shown to be limited by the threshold voltage. Finally, it is observed that the threshold switching event has a voltage dependent delay time.
Multiple Metamagnetic Transitions in the Magnetic Refrigerant<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>La</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>Fe</mml:mi><mml:mo>,</mml:mo><mml:mi>Si</mml:mi><mml:msub><mml:mo stretchy="false">)</mml:mo><mml:mn>13</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">H</mml:mi><mml:mi>x</mml:mi></mml:msub></mml:math> (2008)

The effect of hydrostatic pressure on thermally and field-induced first-order magnetic phase transitions is studied in the La(Fe,Si)_(13)-type compounds. A peculiar series of consecutive field-induced transitions is realized using a distinct combination of hydrostatic pressure and negative pressure created by the interstitial insertion of hydrogen. The pressure-induced discontinuous magnetization jumps result in an enhanced cooling power, thus opening up the possibility to exploit in full the magnetocaloric potential of this compound class.
Cross-resistance between cisplatin and antimony in a human ovarian carcinoma cell line. (1994)

The metal compound cisplatin (DDP) is a widely used anticancer agent but naturally occurring and acquired resistance to DDP limits its effectiveness. Resistance is associated with a decreased accumulation of DDP and increased levels of glutathione and metallothioneins. Such changes also serve as protective and detoxification mechanisms for other metal salts in prokaryotes and lower eukaryotes. The aim of this study was to find metal salts for which the cross-resistance profile was the same as for DDP in sublines of the parental 2008 human ovarian carcinoma cells selected with either DDP (2008/C13*5.25) or CdCl2 and ZnCl2 (2008/MT). Among the metal salts tested the resistance profile of trivalent antimony most closely resembled that of DDP. DDP-selected cells were 15-fold resistant to DDP and 4.4-fold cross-resistant to antimony potassium tartrate, whereas of the cations tested (Cd2+, Zn2+, Ni2+ and Co2+) cross-resistance was observed only for Cd2+ (2.4-fold). When 2008 cells were selected for resistance to antimony (6.6-fold) they were found to be 16-fold cross-resistant to DDP. Accumulation of the DDP analogue cis-[3H]dichloro(ethylenediamine)platinum(II) was 59% lower in the DDP-selected subline and 48% lower in the antimony-selected variant than in the parental cell line. We conclude from the mutual cross-resistance to DDP and antimony potassium tartrate and from the impaired uptake of [3H]DEP in both the DDP and antimony-selected variants that DDP and antimony share a common mechanism of resistance. The significance of this observation lies in the fact that several evolutionarily conserved mechanisms for antimony detoxification are already known in lower organisms which may point the way to identification of additional DDP resistance mechanisms in mammalian cells.