gebhart/patrepeval huggingface dataset:
Three-dimensional eye motion correction by Lissajous scan optical coherence tomography (2017)

A three-dimensional optical coherence tomography imaging method based on Lissajous scanning is presented. This method was designed to correct eye motion in OCT images. A Lissajous scanning pattern, which has a trajectory that frequently overlaps with itself, is adopted as the OCT scanning protocol to obtain measurement data. Eye motion artifacts are then corrected automatically by software. By comparing the images without and with motion correction, we show the effectiveness of our method. We performed an experiment and compared the results obtained by our method with the ground truths to verify its validity. The experimental results showed that our method effectively corrects eye motion artifacts. Furthermore, the sufficient repeatability of our method was confirmed.
The Star Coupler: A Unique Interconnection Component for Multimode Optical Waveguide Communications Systems (1974)

The use of optical waveguides in communications systems may require the interconnection of many interactive terminals. The preferred configuration for passive interconnection in optical waveguide systems is shown to be a configuration termed the Star system. The central interconnecting component, the Star coupler, is described, and the performance of a system incorporating it is compared to that of an equivalent system using a common optical bus and Tee couplers. The Star system is shown to have lower terminal-to-terminal loss, easier upgradability, enhanced reliability and survivability, inherent bidirectionality, and inherent equivalence of all terminals. Construction of two Star couplers is described, and measurements of their performance characteristics are reported.
Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1 (2010)

Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis. Beginning in early 2005, a number of novel mutations involving Janus kinase 2 (JAK2), Myeloproliferative Leukemia Virus (MPL), TET oncogene family member 2 (TET2), Additional Sex Combs-Like 1 (ASXL1), Casitas B-lineage lymphoma proto-oncogene (CBL), Isocitrate dehydrogenase (IDH) and IKAROS family zinc finger 1 (IKZF1) have been described in BCR-ABL1-negative MPNs. However, none of these mutations were MPN specific, displayed mutual exclusivity or could be traced back to a common ancestral clone. JAK2 and MPL mutations appear to exert a phenotype-modifying effect and are distinctly associated with polycythemia vera, essential thrombocythemia and primary myelofibrosis; the corresponding mutational frequencies are approximately 99, 55 and 65% for JAK2 and 0, 3 and 10% for MPL mutations. The incidence of TET2, ASXL1, CBL, IDH or IKZF1 mutations in these disorders ranges from 0 to 17%; these latter mutations are more common in chronic (TET2, ASXL1, CBL) or juvenile (CBL) myelomonocytic leukemias, mastocytosis (TET2), myelodysplastic syndromes (TET2, ASXL1) and secondary acute myeloid leukemia, including blast-phase MPN (IDH, ASXL1, IKZF1). The functional consequences of MPN-associated mutations include unregulated JAK-STAT (Janus kinase/signal transducer and activator of transcription) signaling, epigenetic modulation of transcription and abnormal accumulation of oncoproteins. However, it is not clear as to whether and how these abnormalities contribute to disease initiation, clonal evolution or blastic transformation.
Exploiting multi-level parallelism for low-latency activity recognition in streaming video (2010)

Video understanding is a computationally challenging task that is critical not only for traditionally throughput-oriented applications such as search but also latency-sensitive interactive applications such as surveillance, gaming, videoconferencing, and vision-based user interfaces. Enabling these types of video processing applications will require not only new algorithms and techniques, but new runtime systems that optimize latency as well as throughput. In this paper, we present a runtime system called Sprout that achieves low latency by exploiting the parallelism inherent in video understanding applications. We demonstrate the utility of our system on an activity recognition application that employs a robust new descriptor called MoSIFT, which explicitly augments appearance features with motion information. MoSIFT outperforms previous recognition techniques, but like other state-of-the-art techniques, it is computationally expensive -- a sequential implementation runs 100 times slower than real time. We describe the implementation of the activity recognition application on Sprout, and show that it can accurately recognize activities at full frame rate (25 fps) and low latency on a challenging airport surveillance video corpus.
Color Active Contour Models Based Tongue Segmentation in Traditional Chinese Medicine (2007)

Automated tongue image segmentation in tongue diagnosis system of traditional Chinese medicine is difficult due to two factors: There are lots of pathological details on the surface of tongue, and the shapes of tongue bodies are quite different. By adequately considering color information of tongue images, knowledge-based initial tongue body boundary detection and a color gradient are introduced into the gradient vector flow snake. The roughly detected tongue body boundary is employed to lead the usage of color gradient and the convergence of snake. The experiments results show robustness and accuracy of the algorithm. This work establishes a solid foundation for feature analysis of tongue diagnosis.
F-461, 3-diethylamino-2,2-dimethylpropyl 5-(p-nitrophenyl)-2-furoate hydrochloride, a new non-anticholinergic spasmolytic and gastric acid inhibitor. (1976)

Compound F-461, 3-diethylamino-2,2-dimethylpropyl 5-(p-nitrophenyl)-2-furoate hydrochloride, was evaluated pharmacologically and was found to exert non-anticholinergic smooth muscle spasmolytic activity along the gastrointestinal tract of animals. F-461 was additionally discovered to inhibit gastric acid secretion and to prevent cold + restraint stress-induced ulcers. Local anesthesia, both surface and infiltration, was also elicited by F-461. The pharmacologic properties of F-461, as revealed in this study, are indicative of potential usefulness of this drug in the therapy of spastic colon and/or peptic ulcers.
Role of the CC-1065 and Duocarmycin N2 Substituent: Validation of a Direct Relationship between Solvolysis Chemical Stability and in vitro Biological Potency (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRole of the CC-1065 and Duocarmycin N2 Substituent: Validation of a Direct Relationship between Solvolysis Chemical Stability and in vitro Biological PotencyDale L. Boger and Weiya YunCite this: J. Am. Chem. Soc. 1994, 116, 12, 5523–5524Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/ja00091a088https://doi.org/10.1021/ja00091a088research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
On the aging of avalanche light emission from silicon junctions (1999)

The evolution of photon emission from the emitter-base junctions of bipolar transistors during electrical aging is monitored for the first time. Both electrical and optical characteristics are analyzed. Local variations of light emission intensity are observed for junctions biased at avalanche breakdown. During aging, regions of emission coalesce into small, bright regions; the total emission for the entire junction remains stable and relatively high. Changes in transistor current gain and breakdown voltage correlate with changes in light emission, and are consistent with a hydrogen migration model.
Utilizing student data within the course management system to determine undergraduate student academic success: An exploratory study (2007)

For nearly six decades, researchers have been studying the issues of student persistence and retention in higher education. Despite the decades of research and projects to improve retention, overall retention figures have remained between 45% and 50%. With the contentious debates over the Higher Education Reauthorization Act in 2005 and increasingly constrained federal and state budgets, the demand for increased accountability from the students, families, and the legislature has required higher education institutions to renew their focus on issues of academic quality, cost effectiveness, student retention, and graduation rates. This research expands traditional retention and academic success studies by introducing additional student behavioral data from the course management system (CMS). By examining more than 70,000 records from the CMS, the researcher sought to determine which information, if any, was the strongest indicators of student success. The initial portion of this study reduced the twenty CMS variables into five factors. Subsequent portions of the study utilized regression techniques to identify the key variables necessary to predict academic success. The reduced main model accurately predicted nearly sixty-six percent of the students needing help. A more focused freshmen-only model was able to accurately predict nearly eighty percent of the students needing help. All of the models were validated through the use of an additional sample. While much work remains in the use of analytics to predict student success, this study provides an initial validation that institutions can become more effective by utilizing the course management system as a predictor of academic success. Through the use of academic data, students, faculty members, and academic advisors can be better equipped with additional information to improve the effectiveness of their portion of the academic environment. While additional work remains to develop this research study into a scalable, institutional solution, the framework has been set for utilizing academic information to improve the institution’s academic success and retention efforts. Considering the growing interest in retention within higher education, it is hoped that additional research will conducted to enhance the model within this study, providing academic decision-makers access to a more comprehensive set of tools and information.
Electrically Tunable Plasmonic Behavior of Nanocube–Polymer Nanomaterials Induced by a Redox-Active Electrochromic Polymer (2014)

We present a plasmon-active hybrid nanomaterial design with electrochemical tunability of the localized surface plasmon resonances. The plasmonic-active nanostructures are composed of silver nanocube aggregates embedded into an electrochromic polymer coating on an indium tin oxide electrode with the nanocube aggregation controlled by the surface pressure. Such polymer-nanocube hybrid nanomaterials demonstrated unique tunable plasmonic behavior under an applied electrochemical potential. A significant reversible experimental peak shift of 22 nm at an electrical potential of 200 mV has been achieved in these measurements. Finite-difference time-domain (FDTD) simulations show that, under full oxidation potential, a maximal spectral shift of ca. 80 nm can be potentially achieved, which corresponds to a high sensitivity of 178 nm per refractive index unit. Furthermore, FDTD modeling suggests that the electrochemically controlled tunability of plasmonic peaks is caused by reversible changes in the refractive index of the electrochromic polymer coating caused by oxidation or reduction reactions under external electrical potential. Consequently, we define the orthogonal plasmonic resonance shift as a shift that is orthogonal to the redox process responsible for the refractive index change. On the basis of these results, we suggest that the combination of anisotropic nanostructures and electrochromic matrix has the potential to reversibly electrically tune plasmonic resonances over the full visible spectrum.
Proteomic Parsimony through Bipartite Graph Analysis Improves Accuracy and Transparency (2007)

Assembling peptides identified from LC-MS/MS spectra into a list of proteins is a critical step in analyzing shotgun proteomics data. As one peptide sequence can be mapped to multiple proteins in a database, naïve protein assembly can substantially overstate the number of proteins found in samples. We model the peptide-protein relationships in a bipartite graph and use efficient graph algorithms to identify protein clusters with shared peptides and to derive the minimal list of proteins. We test the effects of this parsimony analysis approach using MS/MS data sets generated from a defined human protein mixture, a yeast whole cell extract, and a human serum proteome after MARS column depletion. The results demonstrate that the bipartite parsimony technique not only simplifies protein lists but also improves the accuracy of protein identification. We use bipartite graphs for the visualization of the protein assembly results to render the parsimony analysis process transparent to users. Our approach also groups functionally related proteins together and improves the comprehensibility of the results. We have implemented the tool in the IDPicker package. The source code and binaries for this protein assembly pipeline are available under Mozilla Public License at the following URL: http://www.mc.vanderbilt.edu/msrc/bioinformatics/.
Long-Term Efficacy and Safety of Repeated Intravescial OnabotulinumtoxinA Injections Plus Hydrodistention in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome (2015)

Intravesical onabotulinumtoxinA (BoNT-A) injection can relieve symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS), but lacks sustainability. Repeated injections have been shown to provide a superior outcome to a single injection, but data on long-term efficacy and safety is limited. In this prospective study, we enrolled patients with refractory IC/BPS, and treated them with 100 U of BoNT-A injection plus hydrodistention followed by repeated injections every six months for up to two years or until the patient wished to discontinue. A "top-up" dose was offered after the fourth injection. Of these 104 participants, 56.7% completed four BoNT-A injections and 34% voluntarily received the fifth injection due to exacerbated IC symptoms. With a follow-up period of up to 79 months, O'Leary-Sant symptom and problem indexes (ICSI, ICPI, OSS), pain visual analogue scale (VAS) functional bladder capacity, frequency episodes, and global response assessment (GRA) all showed significant improvement (p < 0.0001). Those who received repeated injections had a better success rate during the long-term follow-up period. The incidence of adverse events did not rise with the increasing number of BoNT-A injections. A higher pre-treatment ICSI and ICPI score was predictive for successful response to repeated intravesical BoNT-A injections plus hydrodistention.
Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus (1985)

Various commonly used antiseptics were tested against three strains of methicillin-resistant Staphylococcus aureus (MRSA) at stock strength and in serial 10-fold dilutions. The stock solutions of 4% chlorhexidine gluconate-alcohol (Hibiclens), 1% p-chloro-m-xylenol (Acute-Kare), and 3% hexachlorophene (Phisohex) produced 2-log reductions of MRSA after a 15-s exposure, but even after 240 s, these solutions failed to kill all the MRSA. Povidone-iodine (Betadine) solution was maximally effective at the 1:100 dilution, killing all the MRSA within 15 s; other dilutions were less effective, though each killed the MRSA within 120 s. Similar results were obtained with three different strains of methicillin-susceptible S. aureus. Thus, of the four most commonly used antiseptics, povidone-iodine, when diluted 1:100, was the most rapidly bactericidal against both MRSA and methicillin-susceptible S. aureus.
Erichrome Stain for Myelin on Osmicated Tissue Embedded in Glycol Methacrylate Plastic (1989)

This paper describes the modification of the Lieb erichrome technique for staining myelin sheaths' embedded in glycol methacrylate plastic. The technique permits excellent morphologic detail of myelinated and demyelinated axons in the central nervous system and the characterization of pathologic abnormalities in the spinal cord of mice persistently infected with a demyelinating strain of Theiler's virus. It is a simple, rapid technique that allows 25–30 spinal cord cross-sections to be embedded, sectioned and stained at one time. (The J Histotechnol 12:35, 1989).
Verifiable resource accounting for cloud computing services (2011)

Cloud computing offers users the potential to reduce operating and capital expenses by leveraging the amortization benefits offered by large, managed infrastructures. However, the black-box and dynamic nature of the cloud infrastructure makes it difficult for them to reason about the expenses that their applications incur. At the same time, the profitability of cloud providers depends on their ability to multiplex several customer applications to maintain high utilization levels. However, this multiplexing may cause providers to incorrectly attribute resource consumption to customers or implicitly bear additional costs thereby reducing their cost-effectiveness. Our position in this paper is that for cloud computing as a paradigm to be sustainable in the long term, we need a systematic approach for verifiable resource accounting. Verifiability here means that cloud customers can be assured that (a) their applications indeed physically consumed the resources they were charged for and (b) that this consumption was justified based on an agreed policy. As a first step toward this vision, in this paper we articulate the challenges and opportunities for realizing such a framework.
A directory service for a federation of CIM databases with migrating objects (2002)

We propose a novel directory scheme for a large federation of databases where object migration is in response to manufacturing events. In our directory scheme, objects report their location to a directory server instead of the traditional method of the directory servers polling sites in the network. The directory is distributed among multiple servers to avoid bottlenecks during query processing. A distributed linear hashing algorithm is proposed for efficiently determining an appropriate server for an object. Finally, a stochastic dynamic programming model is proposed for minimizing the number of database transactions.
GaN MMIC PAs for E-Band (71 GHz - 95 GHz) Radio (2008)

High data rate E-band (71 GHz- 76 GHz, 81 GHz - 86 GHz, 92 GHz - 95 GHz) communication systems will benefit from power amplifiers that are more than twice as powerful than commercially available GaAs pHEMT MMICs. We report development of three stage GaN MMIC power amplifiers for E-band radio applications that produce 500 mW of saturated output power in CW mode and have > 12 dB of associated power gain. The output power density from 300 mum output gate width GaN MMICs is seven times higher than the power density of commercially available GaAs pHEMT MMICs in this frequency range.
Dynamic load balancing for distributed search (2005)

This paper examines how computation can be mapped across the nodes of a distributed search system to effectively utilize available resources. We specifically address computationally intensive search of complex data, such as content-based retrieval of digital images or sounds, where sophisticated algorithms must be evaluated on the objects of interest. Since these problems require significant computation, we distribute the search over a collection of compute nodes, such as active storage devices, intermediate processors and host computers. A key challenge with mapping the desired computation to the available resources is that the most efficient distribution depends on several factors: relative power and number of compute nodes; network bandwidth between the compute nodes; the cost of evaluating query predicates; and the selectivity of the given query. This wide range of variables renders manual partitioning of the computation infeasible, particularly since some of the parameters (e.g., available network bandwidth) can change during the course of a search. This paper proposes several techniques for dynamic partitioning of computation, and demonstrates that they can significantly improve efficiency for distributed search applications.
Wiener model identification based on adaptive particle swarm optimization (2008)

A novel approach for nonlinear system identification is proposed based on adaptive particle swarm optimization in this paper. Particle swarm optimization is demonstrated as efficient global search method for complex surfaces, and in order to quick the convergence speed, an adaptive particle swarm optimization strategy was introduced. The proposed method formulates the nonlinear system identification as an optimization problem in parameter space, and then adaptive particle swarm optimization are used in the optimization process to find the estimation values of the parameters respectively. Application to Wiener model, in which the nonlinear static subsystems and linear dynamic are separated in different order, is studied and compared with other methods and the simulation results show the identification by adaptive particle swarm optimization is very effective and superior accuracy.
Vom Umgang mit Leben – und seiner Erschaffung (2002)

The insane creator game: A dream reported by a PhD student in my seminar "Dreams on environmental problems" at ETH is discussed ,,Party participants sculpted little human plasticine figures, which might become alive when put into the fridge. Suddenly the dreamer was horrified: She was creating inhuman cripples. Later she hear that in a similar game in Japan a suffering cripple fish had become alive…