gebhart/patrepeval huggingface dataset:
A trace-driven simulator for performance evaluation of cache-based multiprocessor systems (1995)

We describe a simulator which emulates the activity of a shared memory, common bus multiprocessor system with private caches. Both kernel and user program activities are considered, thus allowing an accurate analysis and evaluation of coherence protocol performance. The simulator can generate synthetic traces, based on a wide set of input parameters which specify processor, kernel and workload features. Other parameters allow us to detail the multiprocessor architecture for which the analysis has to be carried out. An actual-trace-driven simulation is possible, too, in order to evaluate the performance of a specific multiprocessor with respect to a given workload, if traces concerning this workload are available. In a separate section, we describe how actual traces can also be used to extract a set of input parameters for synthetic trace generation. Finally, we show how the simulator may be successfully employed to carry out a detailed performance analysis of a specific coherence protocol.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Genes of the Cucurbitaceae1 (1976)

Abstract Nomenclature rules are proposed for naming genes of species in the Cucurbitaceae. Genes of cucumber, muskmelon, watermelon, squash, and other cucurbits are reviewed and, when necessary, changes in gene symbols are proposed. The number of known qualitative factors include 68 genes for the cucumber, 37 for muskmelon, 25 for watermelon, and 30 for Cucurbita species.
Phosphorylation of insulin receptor substrate‐1 serine 307 correlates with JNK activity in atrophic skeletal muscle (2003)

c-Jun NH(2)-terminal kinase (JNK) has been shown to negatively regulate insulin signaling through serine phosphorylation of residue 307 within the insulin receptor substrate-1 (IRS-1) in adipose and liver tissue. Using a rat hindlimb suspension model for muscle disuse atrophy, we found that JNK activity was significantly elevated in atrophic soleus muscle and that IRS-1 was phosphorylated on Ser(307) prior to the degradation of the IRS-1 protein. Moreover, we observed a corresponding reduction in Akt activity, providing biochemical evidence for the development of insulin resistance in atrophic skeletal muscle.
Verbal and design fluency in patients with frontal lobe lesions (2001)

The ability to generate items belonging to categories in verbal fluency tasks has been attributed to frontal cortex. Nonverbal fluency (e.g., design fluency) has been assessed separately and found to rely on the right hemisphere or right frontal cortex. The current study assessed both verbal and nonverbal fluency in a single group of patients with focal, frontal lobe lesions and age- and education-matched control participants. In the verbal fluency task, participants generated items belonging to both letter cues (F, A, and S) and category cues (animals and boys' names). In the design fluency task, participants generated novel designs by connecting dot arrays with 4 straight lines. A switching condition was included in both verbal and design fluency tasks and required participants to switch back and forth between different sets (e.g., between naming fruits and furniture). As a group, patients with frontal lobe lesions were impaired, compared to control participants, on both verbal and design fluency tasks. Patients with left frontal lesions performed worse than patients with right frontal lesions on the verbal fluency task, but the 2 groups performed comparably on the design fluency task. Both patients and control participants were impacted similarly by the switching conditions. These results suggest that verbal fluency is more dependent on left frontal cortex, while nonverbal fluency tasks, such as design fluency, recruit both right and left frontal processes.
Joint design of trajectory and RF pulses for parallel excitation (2007)

We propose an alternating optimization framework for the joint design of excitation k-space trajectory and RF pulses for small-tip-angle parallel excitation. Using Bloch simulations, we show that compared with conventional designs with predetermined trajectories, joint designs can often excite target patterns with improved accuracy and reduced total integrated pulse power, particularly at high reduction factors. These benefits come at a modest increase in computational time.
Purification of the Moloney and Rauscher Murine Leukemia Viruses by Use of Zonal Ultracentrifuge Systems (1967)

The B-IV and B-IX zonal ultracentrifuge rotors were applied to the concentration and purification of the Moloney and Rauscher murine leukemia viruses from large volumes of infected tissue culture fluids and animal materials. Potassium tartrate, potassium citrate and sucrose gradients were used to obtain viral concentrates from the density 1.16 to 1.18 zone. Proteolytic enzyme digestion of tissue culture preparations prior to zonal ultracentrifuge processing was effective in releasing virus from cell debris and producing highly purified, though nonleukemogenic, viral concentrates. Infected Rauscher mouse plasma was processed to give highly purified infectious virus fractions. A single centrifugation of crude Rauscher mouse spleen homogenates resulted in partially purified infectious concentrates with high virus particle counts.
Autonomous Guidance and Flight Control on a Partial-Authority Black Hawk Helicopter (2020)

This paper describes an autonomous guidance and flight control system that was integrated and flight-tested on a partial-authority Black Hawk helicopter. This effort was part of the Degraded Visual Environment Mitigation program, whose objective is to provide all weather capability for U.S. Army rotorcraft operations. The guidance and flight-control system software were previously flight tested on a full-authority helicopter, and for this work, was adapted to fly on a partial-authority helicopter. The main autonomy components of the system consist of the Risk Minimizing Obstacle Field Navigation algorithm, Safe Landing Area Determination algorithm, and the Integrated Cueing Environment. These components provide reactive avoidance guidance, landing site selection, and pilot situational awareness for degraded visual environments. To test the system, a LADAR was used as a surrogate-ranging device in lieu of an all-weather sensor system that was concurrently under development for the program. The autonomous partial-authority flight control system provides a fully stabilized path-following capability that is directed with a series of waypoints or flight-path vector commands. This paper describes the control system, its performance, and how it was adapted to a partial-authority system that is typical of current U.S. Army fleet helicopters. The autonomy software and human interface components are also described. Flight test results are presented of the fully integrated system navigating through terrain, selecting landing sites, and autonomously landing. Analysis is presented that compares partial-authority results to previously collected full-authority results.
Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy (2003)

The protein kinase C (PKC) family is implicated in cardiac hypertrophy, contractile failure, and beta-adrenergic receptor (betaAR) dysfunction. Herein, we describe the effects of gain- and loss-of-PKCalpha function using transgenic expression of conventional PKC isoform translocation modifiers. In contrast to previously studied PKC isoforms, activation of PKCalpha failed to induce cardiac hypertrophy, but instead caused betaAR insensitivity and ventricular dysfunction. PKCalpha inhibition had opposite effects. Because PKCalpha is upregulated in human and experimental cardiac hypertrophy and failure, its effects were also assessed in the context of the Galphaq overexpression model (in which PKCalpha is transcriptionally upregulated). Normalization (inhibition) of PKCalpha activity in Galpha(q) hearts improved systolic and diastolic function, whereas further activation of PKCalpha caused a lethal restrictive cardiomyopathy with marked interstitial fibrosis. These results define pathological roles for PKCalpha as a negative regulator of ventricular systolic and diastolic function.
Identification of RFID tags in dynamic framed slotted Aloha (2009)

Passive RFID tags, which have no self-battery and just backscatter the energy from a reader, share a common channel. It causes a tag-to-tag collision problem when at least two or more tags communicate to the reader simultaneously. The dynamic frame slotted Aloha (DFS-Aloha) protocol is one of the well-known anti-collision algorithms to solve this problem. To maximize the system performance and enhance the reading speed of Aloha protocols, we propose a frame-size estimator which is a modified version of Q-algorithm. To maximize the system performance, the maximum system efficiency value is used by mathematical model of DFS-Aloha. Simulation results show that the proposed estimation algorithm enhances the system performance. The proposed estimation algorithm takes less identification time than DFS-Aloha with the existing Q-Algorithm based on EPC Class 1 Generation 2 protocol.
Angiotensin converting enzyme inhibitors: modifications of a tripeptide analog (1982)

Modified nonhydrolyzable tripeptide analogues of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline (1), designed to impart oral angiotensin converting enzyme (ACE) inhibitory activity, were made and evaluated in vivo and in vitro. The N-methyl and C5-methyl analogues of 1 were inactive. Insertion of heteroatoms (O, S, NH) into the C--C chain of 1 gave a series of compounds with high in vitro activity in the guinea pig serum ACE assay. The O-analogue was the most potent with an IC50 = 4.4 x 10(-9) M compared to 1 with an IC50 = 3.2 x 10(-9) M. The structure-activity relationships in this series of compounds lead one to speculate that the heteroatom provides an additional binding site to the surface of the enzyme; however, these compounds were inactive when tested for antihypertensive activity in the renal hypertensive rat at 30 mg/kg by the oral route (captopril is active at 1.0 mg/kg po).
Gender based differences in diabetic peripheral neuropathy (2014)

Diabetic peripheral neuropathy (DPN) is one of the common complications of diabetes mellitus. Aim: To find out gender based differences in frequency of DM, age at diagnosis of DM and subsequent onset of DPN, duration of DM and DPN and electrophysiological patterns. Methodology: On the basis of non-probability purposive sampling, a cross sectional study was conducted at Neurology department, Mayo Hospital, Lahore. Patients fulfilling the ADA criteria for DM, and DPN were included in the study. Data was analyzed using SPSS 16 version. Results: A total of 125 patients were included in the study with 57/125 (45.6%) males and 68/125 (54.4%) females. This difference in gender based frequency was not statistically significant (p<0.324]. Although mean age of females [51.83+10.04 yrs.] was lower than that of males [53.29+9.39 yrs.] but this difference was also not significant (p<0.504). There was no significant difference (p<0.685) in the mean age at onset of DM in men (42.03+9.97yrs) and women (41.24+10.62yrs). Both genders took a mean period of 08 yrs to develop DPN. The mean age of onset of DPN was 50.87+9.43yrs in men and 49.25+10.62yrs in women and this was not statistically significant (p<0.374). Sensory-motor mixed polyneuropathy was the commonest electrophysiological pattern (51%) seen in both the genders. Conclusion: In our study, gender based differences in DPN are statistically not significant with respect to frequency of diabetes, age at diagnosis of diabetes or at onset of DPN, duration of DM before onset of DPN and electrophysiological patterns. More studies are required to settle whether gender based differences in onset and progression of diabetic neuropathy exist.
Biochemical Functions of Selenium (1992)

Abstract The metabolic role of selenium is largely determined by the reactions catalyzed by selenium-dependent enzymes. At present, two Secontaining glutathione peroxidases are known, one of which exclusively reacts with H2O2 and with a large variety of other hydroperoxides, however not with esterified phospholipid hydroperoxides. The second GSH peroxidase is an interfacial enzyme acting on lipid hydroperoxides including phosphatidyl-choline and cholesterol-hydroperoxide. Recently, a 5-deiodinase activity has been identified as a selenoenzyme which is responsible for the production of active thyroid hormone (T3) from its pro-hormone (T4). A plasma selenoprotein P has been isolated and sequenced which contains as many as 10 selenocysteine residues per molecule. Its function is still unknown. In spite of this increasing information, selenium deficiency in animals and man cannot be simply explained on an enzymological basis. Animal experiments showed that selenium is depleted from these proteins with different rates. Upon resupplementation with selenium, enzyme activities are restored with a different kinetics and a different selenium requirement. Also metabolic changes affecting protein turnover, CO2 exhalation and protein processing have been described in animals. The pattern of inflammatory mediators released upon a stimulus is also much greater in selenium-deficient white blood cells than in controls. These observations suggest a delicate network of interactions of selenium-dependent processes in the metabolism of animals which is by far more complex than previously anticipated.
Molecular cloning and expression of salmon prolactin cDNA (1988)

Prolactin was purified from chum salmon pituitaries. It was resolved into two variants by reverse-phase high-performance liquid chromatography. A cDNA library was prepared from Pacific chinook salmon pituitaries. Salmon prolactin gene was screened using a synthetic oligonucleotide based on partial protein sequence. A positive clone (PRL-10) was identified and sequenced. It is a full-size clone containing 1.1 kb and coding for a preprolactin of 211 amino acids. A modified prolactin plasmid (PRL-10A), in which the 5' untranslated sequence and the nucleotide sequence coding for the signal peptide of prolactin were deleted, was reconstructed into an expression vector using the heat-inducible lambda pL promotor. Mature prolactin, a single polypeptide of 22 kDa, was efficiently expressed in the bacteria at an elevated temperature.
Mechanism of the pivot shift (1990)

The mechanism of the pivot shift was investigated by analysing movements under valgus torque in 29 fresh cadaveric knees. The movements were measured in three dimensions, using biplanar photography, when all the ligaments were intact, and then after the ligaments were sequentially divided. When only the anterior cruciate ligament was sectioned, the pivot shift occurred in seven out of 20 knees examined. In the other 13, though the pivot shift was not observed, an abnormal internal rotation occurred at between 10 degrees and 50 degrees of flexion. Division of the iliotibial tract in addition to division of the anterior cruciate ligament stopped the pivot shift, as the tibia remained internally rotated throughout the range of flexion. The axis of rotation of the pivot shift was located at the medial collateral ligament, which was kept tight by the applied valgus torque. The sudden movement in the pivot shift was caused by a complex interaction between the geometry of the knee and the valgus torque applied.
School Difficulties in 20-Year-Olds Who Were Born Small for Gestational Age at Term in a Regional Cohort Study (2001)

Being born SGA at term is associated with poorer school performance at 12 and 18 years. Fetal adaptation to conditions that retard growth during gestation may not be successful in maintaining brain development.
GaAlAs/GaAs metamorphic Bragg mirror for long wavelengthVCSELs (1998)

A high reflectivity GaAs/AlGaAs Bragg mirror (> 99.7%) has been grown for the first time on InP. Dislocations present in the metamorphic material do not propagate to the active layer. The metamorphic mirror offers a promising alternative to wafer fusion for long wavelength surface-emitting lasers.
Effect of treatment on titer, function, and antigen recognition of serum antibodies to Actinobacillus actinomycetemcomitans in patients with rapidly progressive periodontitis (1994)

Although periodontal treatment by scaling and root planing (SCRP) is known to induce bacteremia, the effect of this procedure on the host immune response is not known. We have determined pre- and post-SCRP immunoglobulin G antibody titers to antigens of Actinobacillus actinomycetemcomitans in the sera of 22 patients with rapidly progressive periodontitis. We also assessed the ability of these sera to enhance phagocytosis and killing of A. actinomycetemcomitans by human polymorphonuclear leukocytes by using a polymorphonuclear leukocyte chemiluminescence (CL) assay. Specific anti-A. actinomycetemcomitans antibody titers were significantly increased at 6 and 12 months after beginning treatment, and CL values were significantly increased at 12 months, whereas mean interproximal pocket depths were significantly decreased at 12 months after beginning treatment. When patients were classified as either seropositive (twice the median titer of control subjects; n = 10) or seronegative (n = 12), both median titers and CL values were significantly increased for the seronegative group at 6 and 12 months after treatment. In the seropositive group, only the median titer was significantly increased at 12 months. Western blot (immunoblot) patterns for six seronegative and six seropositive patients differed remarkably at the baseline. Before treatment, all of the seropositive patients recognized high-molecular-mass lipopolysaccharide (LPS) and a large number of protein components. Patterns were virtually unaffected by therapy. Before treatment, only one of the seronegative patients recognized the LPS smear and none reacted strongly with protein components. Following treatment, slight LPS staining was observed for five of six seronegative patients and detection of protein bands was enhanced in all cases. We conclude that treatment by SCRP induces a humoral immune response, especially in seronegative patients, and that response may play a role in the observed beneficial effects of periodontal treatment.
The conversion of imidazo[1,5-a]pyridines into 3-(2-pyridyl)-1,2,4-oxadiazoles (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe conversion of imidazo[1,5-a]pyridines into 3-(2-pyridyl)-1,2,4-oxadiazolesWilliam W. Paudler and James E. KuderCite this: J. Org. Chem. 1967, 32, 8, 2430–2433Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/jo01283a015https://doi.org/10.1021/jo01283a015research-articleACS PublicationsRequest reuse permissionsArticle Views284Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analyzing the Performance of Multilayer Neural Networks for Object Recognition (2014)

In the last two years, convolutional neural networks (CNNs) have achieved an impressive suite of results on standard recognition datasets and tasks. CNN-based features seem poised to quickly replace engineered representations, such as SIFT and HOG. However, compared to SIFT and HOG, we understand much less about the nature of the features learned by large CNNs. In this paper, we experimentally probe several aspects of CNN feature learning in an attempt to help practitioners gain useful, evidence-backed intuitions about how to apply CNNs to computer vision problems.
Water-based synthesis and cleaning methods for high purity ZnO nanoparticles – comparing acetate, chloride, sulphate and nitrate zinc salt precursors (2014)

The effect of using different zinc salts on size, morphology and photoluminescence of ZnO nanoparticles in high-yield aqueous precipitation synthesis.
Simulation processor “SP” (1989)

Abstract The continuing development of large‐scale and complicated computer systems has created an increasing demand for fast logic simulation which can locate errors in the logic design. The authors have devised a new scheme which makes use of memory instead of registers in controlling the pipeline system. This idea formed the basis for developing a new simulation processor, the “SP”. The SP is a system dedicated for simulation which performs parallel processing using up to 64 gate processors (GP). Using a newly devised pipeline control for each processor delivers high‐speed and inexpensive simulation. By combining processors with a high‐speed switch called ET, the degradation of processing speed due to the delay of information transmission in parallel processing can be prevented. The desired goal was achieved with the construction of the SP, a logic circuit with 4 million gates in which 32 Mbytes of memory could be simulated at high speed.
Expression vectors for human adenosine deaminase gene therapy (1989)

Somatic gene transfer offers a possible new approach for treatment of human genetic disease. Defects affecting blood-forming tissues are candidates for therapies involving transfer of genetic information into hematopoietic stem cells. Adenosine deaminase (ADA) deficiency is being used as a model disease for which gene transfer techniques can be developed and evaluated. We describe here the construction and testing of 20 retroviral vectors for their ability to transfer and express human ADA in vitro and in vivo via a mouse bone marrow transplantation model. After infection of primary bone marrow with one fo these vectors (p delta NN2ADA), human ADA was detected in 60-85% of spleen colonies at day 14 and maintained long term in the blood of fully reconstituted mice. This system offers the opportunity to assess methods for increasing efficiency of gene transfer, for regulation of expression of foreign genes in hematopoietic progenitors, and for long-term measurement of the stability of expression in these cells.
Biosynthesis, Remodelling and Functions of Mammalian GPI-anchored Proteins: Recent Progress (2008)

More than 100 mammalian proteins are post-translationally modified by glycosylphosphatidylinositol (GPI) at their C-termini and are anchored to the cell surface membrane via the lipid portion. GPI-anchored proteins (GPI-APs) have various functions, such as hydrolytic enzymes, receptors, adhesion molecules, complement regulatory proteins and other immunologically important proteins. GPI-anchored proteins are mainly associated with membrane microdomains or membrane rafts enriched in sphingolipids and cholesterol. It is thought that association with membrane rafts is important for GPI-APs in signal transduction and other functions. Here, we review recent progress in studies on biosynthesis, remodelling and functions of mammalian GPI-APs.