gebhart/patrepeval huggingface dataset:
In Vivo Retargeting of Adenovirus Type 5 to αvβ6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery (2009)

A key impediment to successful cancer therapy with adenoviral vectors is the inefficient transduction of malignant tissue in vivo. Compounding this problem is the lack of cancer-specific targets, coupled with a shortage of corresponding high-efficiency ligands, permitting selective retargeting. The epithelial cell-specific integrin alphavbeta6 represents an attractive target for directed therapy since it is generally not expressed on normal epithelium but is upregulated in numerous carcinomas, where it plays a role in tumor progression. We previously have characterized a high-affinity, alphavbeta6-selective peptide (A20FMDV2) derived from VP1 of foot-and-mouth disease virus. We generated recombinant adenovirus type 5 (Ad5) fiber knob, incorporating A20FMDV2 in the HI loop, for which we validated the selectivity of binding and functional inhibition of alphavbeta6. The corresponding alphavbeta6-retargeted virus Ad5-EGFP(A20) exhibited up to 50-fold increases in coxsackievirus- and-adenovirus-receptor-independent transduction and up to 480-fold-increased cytotoxicity on a panel of alphavbeta6-positive human carcinoma lines compared with Ad5-EGFP(WT). Using an alphavbeta6-positive (DX3-beta6) xenograft model, we observed a approximately 2-fold enhancement in tumor uptake over Ad5-EGFP(WT) following systemic delivery. Furthermore, approximately 5-fold-fewer Ad5-EGFP(A20) genomes were detected in the liver (P = 0.0002), correlating with reduced serum transaminase levels and E1A expression. Warfarin pretreatment, to deplete coagulation factors, did not improve tumor uptake significantly with either virus but did significantly reduce liver sequestration and hepatic toxicity. The ability of Ad5-EGFP(A20) to improve delivery to alphavbeta6, combined with its reduced hepatic tropism and toxicity, highlights its potential as a prototype virus for future clinical investigation.
POSITION OF THE ENERGY LEVELS OF TRIVALENT RARE-EARTH ACTIVATOR IONS RELATIVE TO THE ELECTRONIC ENERGY BANDS OF LANTHANUM OXYSULFIDE: A NEW PICTURE OF EXCITATION AND RELAXATION (1970)

It is shown that most rare-earth activators in lanthanum oxysulfide show anomalous thermal quenching effects similar to those previously reported for Eu3+. An analysis of the activation energies derivable from regions of unusually rapid thermal quenching indicates, for all ions observed to date, that the quenching processes represent strong interaction between the 4f electron levels of the rare-earth ions and the conduction band of the host. It thus becomes possible to locate experimentally the positions of the rare-earth levels relative to the host-bands. This in turn allows a general explanation of the excitation and relaxation characteristics of the rare-earth oxysulfide phosphor system.
The path of a jet directed at large angles to a subsonic free stream (1968)

An investigation was made in the Langley 300-MPH 7 -by to-foot tunnel to determine the path and general shape of the wake from a single jet exiting at large angles to the free stream through a range of effective velocity ratios (square root of the ratio of the freestream dynamic pressure to the jet dynamic pressure).The jet-exit deflection angles ranged, in 30 0 increments, from 30 0 to 180 0 from the free stream.Photographs taken of the wakf', which was a mixture of compressed air and water vapor, showed that the jet paths were essentially the same when the jet was exiting upward or downward as well as when the jet was located adjacent to a large surface or located away from adjacent surfaces.The primary variables determining the jet path are the deflection angle of the jet exit and the effective velocity ratio.The results were compared with equations for the jet path from other investigations, and the best empirical fit to these data was determined.
재정의 경기대응성과 경기안정 효과성에 대한 실증분석 (2005)

재정정책이 경기변동에 대하여 경기대응적으로 반응하였는지, 그리고 이러한 경기대응적 재정정책이 경기변동을 줄이는데 실제 효과적이었는지를 94개 국가의 광범위한 자료에 기초하여 실증 분석한다. GDP 대비 재정수입ㆍ재정지출ㆍ재정수지의 비율을 재정의 경기 대응지표로 사용하여 분석하였는데, 전체국가 표본, 비OECD 국가 표본,...
Collision Handling in Dynamic Simulation Environments (2005)

This tutorial will discuss collision detection algorithms with a special emphasis on the provided collision information. The potential combination with collision response schemes will be explained which is particular important for using collision detection algorithms in dynamic simulation environments. The tutorial will cover a large variety of relevant techniques. The tutorial starts with basic concepts, such as boundingvolume hierarchies, spatial partitioning, distance fields, and proximity queries. The idea of image-space collision detection is derived as a special case of spatial partitioning and it is illustrated how graphics hardware can be used to accelerate these methods. Based on the provided collision information, the potential combination with collision response schemes will be discussed for all techniques. The tutorial proceeds with further collision detection challenges that are particular important for dynamic simulation environments. Approaches to self-collision detection, as they can occur in deformable modeling, will be discussed. Stochastic methods, that can be used for time-critical collision detection, will be explained. Further, continuous collision detection will be introduced which aims at solving problems related to discrete-time simulations.
Electro-optical circuit boards using thin-glass sheets with integrated optical waveguides (2008)

The following paper presents research on the manufacture of circuit boards with buried optical waveguides using thin-glass sheets (display glass), which represents a further development of earlier research on buried optical waveguide substrates using polymer. An ion-exchange process was developed to manufacture the waveguides in thin-glass sheets, thereby eliminating the necessity of mechanically structuring the layers. The waveguide properties were simulated and experimentally validated. The circuit board assembly and the concept for the optical coupling from the module to the board and from the board to the backplane are presented. The design and assembly of pluggable electro-optical transmitter and receiver modules is described.
Kinetic Studies of Formaldehyde Binding in Tissue (1994)

Specimens of rabbit liver were fixed for various periods up to 6 days in buffered 14C-formaldehyde. Binding of the isotope reached a plateau after fixation for approximately 24 hr; the half-maximal binding level was reached after approximately 100 min. Formaldehyde binding at 37 C was faster than at 25 C, and faster at pH 7.0 than at pH 4.0. During rinsing of the fixed tissue in water for up to 26 days there was a progressive decrease in isotope content to 10-20% of the pre-rinse level, indicating that formaldehyde fixation is a reversible process.
G.fast Technology and the FTTdp Network (2014)

This white paper gives an overview of use cases and applications of G.fast transmission technology that is currently under development. The goal of G.fast is to deliver data at fiber speed to the customers using telephony copper wires. This solution shall provide high speed services at reasonable deployment cost for many subscribers. Low power consumption and ease of use for the customers are the main goals of the technology. Hardware-based simulations shall demonstrate the capabilities of G.fast for different applications. The channel models used to build different network topologies are based on a joint work of Deutsche Telekom and Lantiq. Lantiq has provided solutions for specific core features of G.fast which are presented in this paper.
High Dielectric VDF/TrFE/CTFE Terpolymers Prepared by Hydrogenation of VDF/CTFE Copolymers:  Synthesis and Characterization (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTHigh Dielectric VDF/TrFE/CTFE Terpolymers Prepared by Hydrogenation of VDF/CTFE Copolymers: Synthesis and CharacterizationZhiming Wang, Zhicheng Zhang, and T. C. Mike ChungView Author Information Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802 Cite this: Macromolecules 2006, 39, 13, 4268–4271Publication Date (Web):May 28, 2006Publication History Received2 April 2006Revised13 May 2006Published online28 May 2006Published inissue 1 June 2006https://pubs.acs.org/doi/10.1021/ma060738mhttps://doi.org/10.1021/ma060738mrapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views1152Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymerization,Copolymers,Electrical properties,Hydrogenation,Monomers Get e-Alerts
End to End Performance Modeling of Web Server Architectures (2000)

Web server performance in a distributed Object-Oriented (OO) environment is a complex interplay between a variety of factors (e.g., hardware platform, threading model, object scope model, server operating system, network bandwidth, disk file size, caching). In this paper, we present a model-based approach to Web Server performance evaluation in terms of an end-to-end queueing model implemented in a simulation tool. We have applied this model to Active Server Page (ASP) and Common Object Model (COM) technology in Microsoft's Internet Information Server and to the Java Server Page (JSP) and JavaBean technology in both IIS and Netscape Enterprise Server (NES). Our results indicate that for the ASP Script Engine, performance predictions from the simulation model matched the performance observed in a test environment. However, for the JSP Script Engine, the model predicted higher throughput than laboratory test results at high load. This result suggests that Web Server performance can be severely limited by a software bottleneck that causes requests to be serialized. This may cause a request to wait for some resource (i.e., a lock) as opposed to consuming CPU or memory. Implications of these results for Web Server performance in general are discussed
Resolution of Allergic Airway Inflammation and Airway Hyperreactivity Is Mediated by IL-17–producing γδT Cells (2010)

This unfolds a new perspective for the understanding of gammadeltaT cell function with regard to innate regulation of the adaptive immune responses, emphasizing that resolution of responses are important in determining the outcome of acute inflammatory episodes as well as for maintenance of tissue integrity and homeostasis.
Expression of the capsular K5 polysaccharide of Escherichia coli: biochemical and electron microscopic analyses of mutants with defects in region 1 of the K5 gene cluster (1993)

The gene cluster of the capsular K5 polysaccharide, a representative of group II capsular antigens of Escherichia coli, has been cloned previously, and three regions responsible for polymerization and surface expression have been defined (I.S. Roberts, R. Mountford, R. Hodge, K. B. Jann, and G. J. Boulnois, J. Bacteriol. 170:1305-1330, 1988). Region 1 has now been sequenced, and five open reading frames (kpsEDUCS) have been defined (C. Pazzani, C. Rosenow, G. J. Boulnois, D. Bronner, K. Jann, and I. S. Roberts, J. Bacteriol. 175:5978-5983, 1993). In this study, we characterized region 1 mutants by immunoelectron microscopy, membrane-associated polymerization activity, cytoplasmic CMP-2-keto-3-deoxyoctonate (KDO) synthetase activity, and chemical analysis of their K5 polysaccharides. Certain mutations within region 1 not only effected polysaccharide transport (lack of region 1 gene products) but also impaired the polymerization capacity of the respective membranes, reflected in reduced amounts of polysaccharide but not in its chain length. KDO and phosphatidic acid (phosphatidyl-KDO) substitution was found with extracellular and periplasmic polysaccharide and not with cytoplasmic polysaccharide. This and the fact that the K5 polysaccharide is formed in a kpsU mutant (defective in capsule-specific K-CMP-KDO synthetase) showed that CMP-KDO is engaged not in initiation of polymerization but in translocation of the polysaccharide.
Curved electronic pixel arrays using a cut and bend approach (2009)

Electronics fabricated on a flat flexible substrate can readily be bent into a cylinder or cone but not into a general three-dimensional curved shape. A solution to this problem is described, in which an electronic device is first fabricated on a flat surface and then shaped to a good approximation of any smooth curved shape, using a cut and bend approach, following the design principles of a geodesic dome. A small additional strain allows the surface to conform to an exact spherical cap. The array is fabricated with amorphous silicon thin film transistors and photodiodes on a plastic substrate.
Object-oriented chemical process modeling in Omola (2003)

An object-oriented approach to modeling chemical processes with control systems in the modeling language Omola is discussed. The basic elements in this modeling methodology are modularization, model encapsulation, hierarchical decomposition, parameterization and inheritance. Models have an internal structure of model components, like terminals, parameters and behavior descriptions. The model behavior can be described by equations or as a connected structure of submodels. Models and model components are represented as objects in single inheritance object class hierarchies. Chemical processes and control systems can be described with the same basic concepts. The object-oriented model representation is implemented in the Omola simulation environment, called OmSim. An exothermic tank reactor example is successfully modeled and simulated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Azidiniumsalze, V. Symmetrische Azopyrazolon‐(5)‐Farbstoffe durch Azogruppen‐Übertragung heterocyclischer Azidiniumsalze auf 1‐[X‐Phenyl]‐3‐methyl‐pyrazolone‐(5) (1966)

Abstract Azopyrazolon‐(5)‐Farbstoffe ( 5 ; Tab. 1) wurden durch Azogruppen‐Übertragung heterocyclischer Azidiniumsalze 1 auf 1‐[X‐Phenyl]‐3‐methyl‐pyrazolone‐(5) ( 4 : X = H, CO 2 H, CO 2 C 2 H 5 , Cl, NO 2 , SO 3 Na) synthetisiert. Kinetische Untersuchungen der Farbstoffsynthese sprechen für einen Mehrstufen‐Mechanismus mit intermediärer Bildung von 4‐Diazopyrazolonen‐(5) (z. B. 14 ).
P-GAP-43 Is Enriched in Horizontal Cell Divisions throughout Rat Cortical Development (2006)

Asymmetric cell divisions are correlated to neurogenesis in the mammalian cortex and occur often with a horizontal orientation of cell division. However, the molecular mechanisms of spindle orientation or asymmetric cell divisions are not well understood in the developing mammalian central nervous system. Here we show a new molecular marker for horizontally dividing precursors in the mammalian telencephalon. The antibody 2G12 directed against phosphorylated serine of growth associated protein 43 (GAP-43) labels postmitotic neurons and a subset of cells in mitoses in the developing rat telencephalon. 2G12 immunoreactivity was found at a high frequency in mitotic cells dividing parallel to the ventricular surface throughout neurogenesis (embryonic day 13-17) in the cerebral cortex and ganglionic eminence. Interestingly, we detected the same predominance of 2G12 immunoreactivity in horizontally dividing cells in the subventricular zone, the second proliferative layer that has recently been involved in the generation of neurons. Moreover, 2G12 immunostaining is no longer detectable in mitotic cells of the ventricular zones at E21, the onset of gliogenesis in rat telencephalon. These data imply GAP-43 phosphorylation in the phase of neuronal commitment during M-phase and present to our knowledge the first molecular correlate to horizontally dividing precursors in mammalian neurogenesis.
Observations and Near-Direct Implementations of the Ascending Proxy Auction (2005)

Abstract This chapter presents an analysis of various suggested methods to accelerate the primary and practical implementation of the ascending proxy auction mechanism without compromising on its desired economic properties. Three approaches for accelerating a direct implementation of the ascending proxy algorithm are presented. The first approach, known as safe start, involves working backward from the efficient allocation and starting with the Vickrey prices; the second, increment scaling, provides a solution to the problem by considering bid increments; and the third one, referred as increment scaling with safe start, combines the two approaches previously discussed. The chapter shows how the desired economic properties of the Ausubel-Milgrom ascending proxy auction design can be achieved by implementing the combined safe-start increment-scaling algorithm.
Biological and prognostic role of acid cysteine proteinase inhibitor (ACPI, cystatin A) in non-small-cell lung cancer (2006)

ACPI expression is linked with the malignant transformation of the bronchial epithelium and predicts a risk of tumour recurrence as well as poor rate of survival for the patients. However, ACPI does not have any independent prognostic value in NSCLC.
Optimizing queries on files (1994)

We present a framework which allows the user to access and manipulate data uniformly, regardless of whether it resides in a database or in the file system (or in both). A key issue is the performance of the system. We show that text indexing, combined with newly developed optimization techniques, can be used to provide an efficient high level interface to information stored in files. Furthermore, using these techniques, some queries can be evaluated significantly faster than in standard database implementations. We also study the tradeoff between efficiency and the amount of indexing.
Effectiveness of Cinnamon for Lowering Hemoglobin A1C in Patients with Type 2 Diabetes: A Randomized, Controlled Trial (2009)

Taking cinnamon could be useful for lowering serum HbA1C in type 2 diabetics with HbA1C >7.0 in addition to usual care.
Assessing a population's exposure to heat and humidity: an empirical approach (2010)

Small battery-powered automatic dataloggers proved to be a feasible option for collecting weather data among a rural South African population. These data were consistent with external sources but offered more local detail. Detailed local contemporary data may also allow post hoc modelling of previously unmeasured local weather data in conjunction with global gridded climate models.
Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip (2016)

Cell adhesion processes are of ubiquitous importance for biomedical applications such as optimization of implant materials. Here, not only physiological conditions such as temperature or pH, but also topographical structures play crucial roles, as inflammatory reactions after surgery can diminish osseointegration. In this study, we systematically investigate cell adhesion under static, dynamic and physiologically relevant conditions employing a lab-on-a-chip system. We screen adhesion of the bone osteosarcoma cell line SaOs-2 on a titanium implant material for pH and temperature values in the physiological range and beyond, to explore the limits of cell adhesion, e.g., for feverish and acidic conditions. A detailed study of different surface roughness <i>R<sub>q</sub></i> gives insight into the correlation between the cells' abilities to adhere and withstand shear flow and the topography of the substrates, finding a local optimum at <i>R<sub>q</sub></i> = 22 nm. We use shear stress induced by acoustic streaming to determine a measure for the ability of cell adhesion under an external force for various conditions. We find an optimum of cell adhesion for <i>T</i> = 37 °C and pH = 7.4 with decreasing cell adhesion outside the physiological range, especially for high T and low pH. We find constant detachment rates in the physiological regime, but this behavior tends to collapse at the limits of 41 °C and pH 4.
The Boundary Surface Control Principle and Its Applications (2005)

In order to control a sound field using multiple sources and microphones, we must choose the optimum values of parameters such as the numbers of sources and microphones, the location of the sources and the microphones and the filter tap length. Because there is a huge number of possible combinations of these conditions, the boundary surface control principle can be useful as a basis of a design method of such a system. In this paper, a design method of sound field reproduction and active noise control based on the BSC principle are described and several example of its application are presented.
Gesture recognition in flow based on PCA analysis using multiagent system (2008)

Our context is Virtual Theater. Our aim is to put on a short play featuring a real actor and a virtual actor, who will communicate through movements and choreography with mutual synchronization. We currently work on a system that can recognize key-gestures made by a real actor.
Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain. (2010)

Age-related changes in innate immune function and glial-neuronal communication are early and critical events in brain aging and neurodegenerative disease, and lead to a chronic increase in oxidative stress and inflammation, which initiates neuronal dysfunction and reduced synaptic plasticity, and ultimately disruption in learning and memory in the aged brain. Several lines of evidence suggest a correlation between adult neurogenesis and learning. It has been proposed that a decline in hippocampal neurogenesis contributes to a physiologic decline in brain function. Recently, new and important insights relating to the production of new neurons affecting hippocampal-dependent memory ability have been provided. A multitude of factors have been shown to regulate the production of new neurons in the adult hippocampus, many of which change as a result of aging. Yet, the potential importance of neurogenesis in some affective and cognitive behaviors, as well as endogenous tissue repair mechanisms, makes further investigation of neurogenic regulators warranted. We have recent evidence that key regulators of communication between neurons and microglia are disrupted in the aged brain and may be one of the factors that precedes and initiates the observed increase in chronic inflammatory state. In this review the role of dysfunction in these neuronal-glial communication regulators underlying age-related impairments in cognition and hippocampal neurogenesis will be discussed. An understanding of these mechanisms will lead to the development of preventive or protective therapies.