gebhart/patrepeval huggingface dataset:
Cytochemical demonstration of increased phospholipid content in cell membranes in chlorphentermine-induced phospholipidosis. (1989)

We recently introduced a novel cytochemical approach to high-resolution cytochemistry of phospholipids in biological tissues. The technique consists of adsorption of bee venom phospholipase A2 to colloidal gold particles (PLA2-gold complex) and subsequent application of this complex for localization of the enzyme substrate, i.e., glycerophospholipids. In the present study, this technique was applied at the post-embedding level, in both light (LM) and transmission electron microscopy (TEM), to investigate drug-induced phospholipidosis, an experimental disorder in which the lysosomal catabolism of phospholipids is inhibited. Rats received one week of daily treatment (40 mg IP/kg) with chlorphentermine (CP), a cationic amphiphilic drug known to induce phospholipidosis in several tissues. Glutaraldehyde- and osmium-fixed lung and kidney tissues from both treated and control animals, were embedded in Epon and sections processed for labeling by PLA2-gold. In CP-treated specimens the presence of large osmiophilic inclusions in several cell types of lung parenchyma and kidney cortex confirmed the onset of phospholipidosis. These inclusions were densely labeled by PLA2-gold at both LM and TEM levels. Two general types of abnormal inclusions were distinguished on the basis of their ultrastructure and labeling pattern by PLA2-gold, suggesting different content or configuration of phospholipids. Moreover, quantitative evaluation of labeling density over various membrane compartments in lung alveolar cells evidenced significantly increased phospholipid content after CP treatment. In type II pneumocytes, such increases were measured in membranes of the RER, Golgi complex, outer and inner nuclear envelope, and the basolateral and apical domains of the plasma membrane. In capillary endothelial cells, the basal and luminal domains of the plasma membrane also showed an increase in labeling density. These results further demonstrate the potential usefulness of the PLA2-gold technique for in situ ultrastructural localization of phospholipids in normal and pathological tissues.
40Ar/39Ar ages of the high-P/T metamorphic rocks of the Heilongjiang Complex in the Jiamusi Massif, northeastern China (2009)

The Heilongjiang Complex in northeastern China is composed mainly of alternating blueschists and pelitic schists which underwent high-P/T type metamorphism of the epidote blueschist facies. Phengites in the pelitic schists from two areas in the Heilongjiang Complex yielded 40Ar/39Ar plateau ages of 165 ± 0.8 Ma (Mudanjiang area) and 171 ± 0.7 Ma (Yilan area). Phengites in blueschists from the Yilan area give 40Ar/39Ar isochron ages of 145 ± 0.9 Ma and 146 ± 1.3 Ma. The previously reported peak metamorphic temperature of 350-450 °C for the Heilongjiang Complex is close to the Ar retention temperatures of white mica, suggesting that the ages reported here closely date the metamorphic culmination in this complex. These ages indicate that a widespread high-P/T metamorphism occurred in the Heilongjiang Complex at 165-171 Ma. Subsequent to this period, a similar type of metamorphism continued at least until 145-146 Ma in the Yilian area.
The minimal cost distribution tree problem for recursive expiration-based consistency management (2004)

The expiration-based scheme is widely used to manage the consistency of cached and replicated contents such as Web objects. In this approach, each replica is associated with an expiration time beyond which the replica has to be validated. While the expiration-based scheme has been investigated in the context of a single replica, not much work has been done on its behaviors with respect to multiple replicas. To allow for efficient consistency management, it is desirable to organize the replicas into a distribution tree where a lower level replica seeks validation with a higher level replica when its lifetime expires. This paper investigates the construction of a distribution tree for a given set of replicas with the objective of minimizing the total communication cost of consistency management. This is formulated as an optimization problem and is proven to be NP-complete. The optimal distribution tree is identified in some special cases and several heuristic algorithms are proposed for the general problem. The performance of the heuristic algorithms is experimentally evaluated against two classical graph-theoretic algorithms of tree construction: the shortest-paths tree and the minimum spanning tree.
Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. (2010)

Inhibition of LAT1 may be a new rationale to the effective therapy of NSCLC without EGFR mutation.
<i>In vitro</i> generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation (2006)

This study instituted a unique approach to bone tissue engineering by combining effects of mechanical stimulation in the form of fluid shear stresses and the presence of bone-like extracellular matrix (ECM) on osteodifferentiation. Rat marrow stromal cells (MSCs) harvested from bone marrow were cultured on titanium (Ti) fiber mesh discs for 12 days in a flow perfusion system to generate constructs containing bone-like ECM. To observe osteodifferentiation and bone-like matrix deposition, these decellularized constructs and plain Ti fiber meshes were seeded with MSCs (Ti/ECM and Ti, respectively) and cultured in the presence of fluid shear stresses either with or without the osteogenic culture supplement dexamethasone. The calcium content, alkaline phosphatase activity, and osteopontin secretion were monitored as indicators of MSC differentiation. Ti/ECM constructs demonstrated a 75-fold increase in calcium content compared with their Ti counterparts after 16 days of culture. After 16 days, the presence of dexamethasone enhanced the effects of fluid shear stress and the bone-like ECM by increasing mineralization 50-fold for Ti/ECM constructs; even in the absence of dexamethasone, the Ti/ECM constructs exhibited approximately a 40-fold increase in mineralization compared with their Ti counterparts. Additionally, denatured Ti/ECM* constructs demonstrated a 60-fold decrease in calcium content compared with Ti/ECM constructs after 4 days of culture. These results indicate that the inherent osteoinductive potential of bone-like ECM along with fluid shear stresses synergistically enhance the osteodifferentiation of MSCs with profound implications on bone-tissue-engineering applications.
A new monitoring system to measure metals dissolved in water by means of room-temperature phosphorescence optical fiber sensors (2002)

In this paper a relatively simple, low-cost industrial prototype for measuring concentrations of metals dissolved in water is presented. The operation of this system is based on the measuring of the light emission intensity of the chemical sensors. This kind of system provides simultaneous on-line multiple measurements and it has major advantages over other present techniques, such as excellent sensitivity and stability, high precision and selectivity, good time response and low maintenance cost.
A survey of fast packet switches (1989)

With the advent of optical fiber and its large bandwidth, many services, such as packetized data, voice, and video, are now becoming available on physical transmission lines. The high data rates, however, have created a demand for high speed switching. Included among the different strategies which have been proposed are fully- and non-fully-connected switches, intelligent and non-intelligent switching nodes, broadcast capability, input and output queueing, input concentration and output reentry, and path preallocation. Most switches have a modular design. This paper compares the Knockout Switch [1], a switch designed by Jonathan Turner [2, 3], a switch designed by Joseph Hui and Edward Arthurs [4], and the Starlite Switch [5] based on the strategies listed above. Advantages and disadvantages are cited and conclusions have been made about the tradeoffs involved with operating conditions. Finally, future issues affecting fast packet switching are described.
Capacitive floating level shifter: Modeling and design (2015)

This paper introduces the failure operation principle of the capacitive floating level shifter, as well as its simplified circuit model. Based on the model, the mathematical equations for analyzing the level shifter's characteristics and its respective performances are also derived. Design criteria for the capacitive floating level shifter are proposed derived from the model and corresponding MATLAB simulation results. Furthermore, transistor-level simulations using 65-nm CMOS technology verify the deduced simplified circuit model and the proposed design criteria, following which, overdesign can be avoided to guarantee the proper operation of the floating capacitive level shifter, thus saving chip area and reducing cost.
Switching behavior of plasma polymer films containing silver nanoparticles (2003)

A reversible electronic switching effect has been observed in plasma polymer films with embedded silver nanoparticles. The electrical and nanostructural properties of the films have been investigated, and three different structure types were observed: metallic, percolation, and dielectric. While for the metallic and dielectric types, respectively, metallic conduction and thermally activated tunneling can be identified as the dominant electronic conduction mechanisms, switching appears only in percolation structures. These drastic, abrupt changes of up to six orders of magnitude in the current–voltage behavior are highly reversible for these nanocomposite materials, and are defined as threshold switching.
An Adaptive Parallel Tempering Algorithm (2013)

Abstract Parallel tempering is a generic Markov chain Monte Carlo sampling method which allows good mixing with multimodal target distributions, where conventional Metropolis-Hastings algorithms often fail. The mixing properties of the sampler depend strongly on the choice of tuning parameters, such as the temperature schedule and the proposal distribution used for local exploration. We propose an adaptive algorithm with fixed number of temperatures which tunes both the temperature schedule and the parameters of the random-walk Metropolis kernel automatically. We prove the convergence of the adaptation and a strong law of large numbers for the algorithm under general conditions. We also prove as a side result the geometric ergodicity of the parallel tempering algorithm. We illustrate the performance of our method with examples. Our empirical findings indicate that the algorithm can cope well with different kinds of scenarios without prior tuning. Supplementary materials including the proofs and the Matlab implementation are available online. Key Words: Adaptive MCMCLaw of large numbersMultimodality SUPPLEMENTARY MATERIALS Proofs: The proofs of all the results in this article are given in the supplementary document (supplemental-pt.tex, LaTeX file) Matlab implementation: Matlab implementation of the adaptive parallel tempering algorithm. (apt-codes.zip, Zip file) ACKNOWLEDGMENTS The first two authors were supported by the French National Research Agency under the contract ANR-08-BLAN-0218 "BigMC." The third author was supported by the Academy of Finland (project 250575) and by the Finnish Academy of Science and Letters, Vilho, Yrjö and Kalle Väisälä Foundation. Notes The Matlab-implementation is available at http://iki.fi/mvihola/apt-codes.zip.
Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia (2009)

Overall these results suggest that interleukin-10 and type 1 regulatory cells are associated with persistent mixed chimerism and may play an important role in sustaining long-term tolerance in vivo. These data provide new insights into the mechanisms of peripheral tolerance in chimeric patients and support the use of cellular therapy with regulatory T cells following hematopoietic stem cell transplantation.
Control modulation technique for client independent optical performance monitoring and transport of channel overhead (2003)

A new subcarrier technique for optical performance monitoring and transport of channel overhead independent of the client data and without optoelectronic conversion in the client data path has been verified experimentally performing loop tests with PRBS bit error measurements for the example of a 10 Gb/s client channel and a 50 Mb/s control channel converted to an RF subcarrier above the client modulation spectrum. Strict correlation between the client channel the ASE noise of optical amplifiers and nonlinear distortion due to self phase modulation (SPM). An early warning function of the control channel is realised by proper choice of the modulation depth. A pronounced BER degradation in the control channel indicates a beginning degradation in the client channel. This feature enables preemptive performance management, i.e. management can take measures in good time to prevent the network from outages and maintain the quality of service. It was shown for the measurement example that the control signal together with the client signal can be transmitted error free over distances up to 1653 km. This enables transport of channel overhead or labelling for optical burst and packet networks. The overhead or label maybe protected against degradation of optical transmission by implementing a forward error correction (FEC) in the control channel. The activity of the error correction algorithm can be used as a quality measure instead of a direct BER measurement.
Determination of Shallow Acceptor Concentration in  SI  ‐ GaAs from Steady‐State and Transient Microwave Photoconductivity Measurements (1990)

A non‐destructive characterization method using microwaves has been employed to determine the shallow acceptor concentration in undoped LEC semi‐insulating gallium arsenide wafers. Both the above‐bandgap steady‐state and the below‐bandgap transient photoconductivities of wafers are measured using a Ka‐band reflection‐type microwave setup in which there is no need to fabricate electrical contacts on wafers. A photoconductivity model adopted from the two‐energy‐level defect model for undoped LEC semi‐insulating is used to derive the relationship between the photoinduced microwave response and the concentration of shallow acceptors, mainly carbon. In the above‐ bandgap photoconductivity measurement, it is found that the steady‐state microwave response is inversely proportional to the square root of the shallow acceptor concentration. In the below‐bandgap photoconductivity measurement, the transient microwave response shows an initial fast decay and a second slower decay which has a Na‐related decay time constant. More than 30 undoped LEC bulk wafers were used in our measurements to establish the correlation. These wafers have a carbon concentration ranging from to , determined by LVM infrared absorption. Good agreements have been found between the shallow acceptor concentration obtained from the microwave photoconductivity measurements and the LVM carbon concentration.
Estimating the Health Risks of Radon in Drinking Water (1987)

By combining information about the occurrence, transport, exposure, and health effects of radon in drinking water, it has been estimated that over a period of 70 years (the average lifetime in the United States), between 2000 and 40 000 lung cancer fatalities are caused by inhalation of natural radon released from US public water supplies. The average concentration of radon in these water supplies generates a lifetime risk of about 1 in 10 000, the highest level of risk allowed for any contaminant currently regulated under the Safe Drinking Water Act. Reducing the levels of radon in drinking water, which would significantly lessen the risks to health, has been found to be feasible by either aeration or treatment with granular activated carbon.
20‐(<i>S</i>)‐Camptothecin Analogues as DNA Topoisomerase I Inhibitors: A QSAR Study (2007)

The interest in the application of the quantitative structure-activity relationships (QSAR) has steadily increased in recent decades because it has repeatedly proven itself to be a low-cost, high-return investment. Potential use of QSAR models for screening of chemical databases or virtual libraries before their synthesis appears equally attractive to chemical manufacturers, pharmaceutical companies, and government agencies. We hope it may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. In this paper, two series of camptothecin derivatives were undertaken to correlate DNA topo I inhibition with their hydrophobic and steric properties, to understand their chemical-biological interactions. The resulting QSAR have shown that the inhibitory activity of camptothecin analogues 4 toward DNA topo I is mainly dependent on their hydrophobic and steric descriptors, whereas the same activity of 10,11-methylenedioxy- camptothecin analogues 5 is largely dependent on their hydrophobicity at position-7. Using internal [cross-validation, quality factor (Q), Fischer statistics (F), and Y-randomization tests] and external validation tests both of these QSAR models have been validated. Both series of these camptothecin derivatives are also filtered by Lipinski's rule of five to check their oral bioavailability. On the basis of these QSAR models, five compounds (4-35, 4-36, 5-20, 5-21, and 5-22) have been predicted that may be the next synthetic target. These molecules also fulfill the conditions of Lipinski's rule of five.
Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees (2007)

Recombinant hepatitis C virus (HCV)-like particles (HCV-LPs) containing HCV structural proteins (core, E1, and E2) produced in insect cells resemble the putative HCV virions and are capable of inducing strong and broad humoral and cellular immune responses in mice and baboons. Here, we present evidence on the immunogenicity and induction of protective immunity by HCV-LPs in chimpanzees. Chimpanzees (two in each group), were immunized with HCV-LPs or HCV-LPs plus AS01B adjuvant. After immunizations, all animals developed an HCV-specific immune response including IFN-gamma(+), IL-2(+), CD4(+), and CD8(+) T cell and proliferative lymphocyte responses against core, E1, and E2. Upon challenge with an infectious HCV inoculum, one chimpanzee developed transient viremia with low HCV RNA titers (10(3) to 10(4) copies per ml) in the third and fourth weeks after the challenge. The three other chimpanzees became infected with higher levels of viremia (10(4) to 10(5) copies per ml), but their viral levels became unquantifiable (<10(3) copies per ml) 10 weeks after the challenge. After the HCV challenge, all four chimpanzees demonstrated a significant increase in peripheral and intrahepatic T cell and proliferative responses against the HCV structural proteins. These T cell responses coincided with the fall in HCV RNA levels. Four naïve chimpanzees were infected with the same HCV inoculum, and three developed persistent infection with higher viremia in the range of 10(5) to 10(6) copies per ml. Our study suggests that HCV-LP immunization induces HCV-specific cellular immune responses that can control HCV challenge in the chimpanzee model.
WHO model formulary (2003)

WHO Model Formulary. M. R. Couper & D. K. Mehta (editors). Geneva: World Health Organization, 2002. vi + 517pp. Price Sw.fr.40/US$36 (in developing countries Sw.fr.28). ISBN 92-4-154449-3 WHO Model Formulary. Couper M.R.Mehta D.K.. Geneva: World Health Organization, 2002. vi + 517pp. Price Sw.fr.40/US$36 (in developing countries Sw.fr.28). ISBN 92-4-154449-3. R.H. Behrens R.H. Behrens Senior Lecturer, Travel Medicine Clinical Research Unit Infectious and Tropical Disease Department London School of Hygiene and Tropical Medicine Keppel Street London WC1 E 7HT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 97, Issue 1, January-February 2003, Page 15, https://doi.org/10.1016/S0035-9203(03)90006-X Published: 01 January 2003
Studies of antitumor activity of the culture filtrate of Hohenbuehelia geogenius (D.C. ex Fr.) Sing (basidiomycete). (1981)

The antitumor activity of the culture filtrate of the fungus Hohenbuehelia geogenius (basidiomycete) was investigated on two rapidly growing grafted tumors: Ehrlich's ascites carcinoma and L1210 lymphoid leukemia and also on a slow growing spontaneous mammary tumor in PS strain mice. The mycelial culture filtrate inhibited the growth of these three tumors. An active substance was isolated from the mycelial culture filtrate by solid-liquid extraction and column chromatography. Its chemical structure was elucidated with ultraviolet and infrared spectra, mass spectrum, nuclear magnetic resonance, and X-ray diffraction.
PVT measurements of hydrogen/methane mixtures at high pressures (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPVT measurements of hydrogen/methane mixtures at high pressuresJose R. S. Machado, William B. Streett, and Ulrich DietersCite this: J. Chem. Eng. Data 1988, 33, 2, 148–152Publication Date (Print):April 1, 1988Publication History Published online1 May 2002Published inissue 1 April 1988https://pubs.acs.org/doi/10.1021/je00052a027https://doi.org/10.1021/je00052a027research-articleACS PublicationsRequest reuse permissionsArticle Views249Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts