gebhart/patrepeval huggingface dataset:
Diversity of cAMP-Dependent Protein Kinase Isoforms and Their Anchoring Proteins in Mouse Ventricular Tissue (2007)

Using a chemical proteomics approach, we efficiently enriched for the generally low abundant cAMP signaling proteins, and their interactors, directly from mouse ventricular tissue. The presence of undesired contaminating (noncyclic) nucleotide-binding proteins was diminished using a tailored sequential elution protocol. Through further optimization of this affinity purification and elution protocol, we were able to detect all known protein kinase A regulatory isoforms (PKA-R). Furthermore, 11 different A-kinase anchoring proteins (AKAPs) were detected. A proposed fusion protein of paralemmin 2 and AKAP2 could be decisively established as a novel AKAP at the protein level in ventricular tissue. When comparing this dataset of cAMP-affinity purified proteins with earlier data obtained with immobilized cGMP from rat ventricular tissue, we observe a large overlap in the retained proteins but also some clear differences. Furthermore, implementation of an in-depth analysis of in vivo phosphorylation sites on PKA-R revealed the presence of several differentially phosphorylated PKA-R isoforms. This illustrates yet another layer of functional regulation in cyclic nucleotide signaling. In general, our improved chemical proteomics screen offers a broad, but detailed, view on nature's complex diversity in cyclic nucleotide signaling mechanisms. Possibly different AKAP-isoforms may direct differentially phosphorylated PKA-R isoforms to different cellular compartments, providing a multifaceted platform for just this kinase.
Characterization of the DNA polymerase loci of the novel porcine lymphotropic herpesviruses 1 and 2 in domestic and feral pigs (1999)

Two novel porcine gammaherpesviruses, porcine lymphotropic herpesviruses 1 and 2 (PLHV-1 and -2), have been detected by amplification of short DNA polymerase (DPOL) sequences from blood and spleen of domestic pigs while searching for unknown herpesviruses in pigs as possible risk factors in xenotransplantation. In the present study, the DPOL genes of the two viruses and the open reading frames (ORFs) that follow in the downstream direction were amplified by PCR-based genome walking from adaptor-ligated restriction fragment libraries of porcine spleen samples. The sequences determined for the two PLHVs exhibited a very low G+C content (37 mol%) and a marked suppression of the CpG dinucleotide frequency. The DPOL proteins encoded were 95% identical and showed a close relationship (60% identity) to the DPOL protein of a ruminant gammaherpesvirus, alcelaphine herpesvirus 1 (AlHV-1). This was confirmed by phylogenetic analyses of the conserved regions of the two PLHV DPOL proteins. The PLHV ORFs downstream of DPOL exhibited 83% identity to each other and >>50% similarity to ORF A5, the position equivalent of AlHV-1. From these data, the PLHVs can be firmly classified to the subfamily Gammaherpesvirinae: To find a natural reservoir for the PLHVs, organs of feral pigs were screened with five different PCR assays, targetting either the DPOL gene or 3'-flanking sequences. In all samples, PLHV sequences were detected that originated predominantly from PLHV-2, suggesting the possibility of virus transfer between feral and domestic pig populations.
One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta (1990)

A cDNA encoding human endothelin 3 (ET-3) precursor was cloned from a cDNA library from the placenta, and its nucleotide and deduced amino acid sequences were determined. This ET-3 cDNA was found to contain 2.3 kb pairs and encode prepro-ET-3 protein consisting of 224 amino acid residues. The putative big-ET-3 seems to consist of 42 amino acid residues. Two of the intron insertion sites were determined with information from nucleotide sequences of the cloned genomic ET-3 gene. This is the first direct evidence that the ET-3 gene is transcribed and expressed in the placenta.
Implementing ICVS regional shared transportation system in Singapore (2003)

Honda has developed a practical new concept in transportation, the intelligent community vehicle system (ICVS), which provides the comfort and freedom of personal transportation while offering a more efficient resource utilization and an improved living environment, by using a system featuring the shared use of environmentally friendly vehicles. Since 1994, Honda has been conducting research and testing of the system in regions around the world. Based on these results and with the support from Singapore's Economic Development Board, Honda is to commence operation of an ICVS In Singapore in 2002. Through a combination of three usage patterns the vehicles are to be used to their maximum potential, and members will be provided with an easy-to-use, pay-per-use service.
Macrophage migration inhibitory factor (2002)

Macrophage migration inhibitory factor (MIF) has been proposed to be the physiologic counter-regulator of glucocorticoid action within the immune system. In this role, MIF’s position within the cytokine cascade is to act in concert with glucocorticoids to control both the “set point” and the magnitude of the inflammatory response. As well as overriding the immunosuppressive effects of glucocorticoids, it is now well established that MIF has a direct proinflammatory role in inflammatory diseases, such as sepsis, rheumatoid arthritis, and glomerulonephritis. The functions of MIF within the immune system are both unique and diverse, and although a unified molecular mechanism of action remains to be elucidated, there have been significant advances in our understanding of how MIF affects cellular processes. This review discusses the pathogenic role of MIF in inflammatory disease and highlights the novel structural, functional, and mechanistic properties of MIF.
Finite Element Analysis Model of High Cycle Fatigue Damage for Metal Structure (2006)

This paper gets some material constants of elastic and plastic fatigue damage evolutionary equations from high and low cycle fatigue experiments of unnotched metal samples on the basis of fundamental principles of damage mechanics. Then, the finite element program ANSYS is used to simulate the development of crack of notched metal samples under high cycles of constant-amplitude stress and the distributions of elastic and plastic areas and so on. The whole variation of stress field, strain field and damage field are completely described. Finally, to compare it with the experimental results, the applicability and practicability of the model is appraised.
Synthesis of (carbyne)metal complexes by oxide abstraction from acyl ligands (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (carbyne)metal complexes by oxide abstraction from acyl ligandsAndreas Mayr, Gregory A. McDermott, and Alison M. DorriesCite this: Organometallics 1985, 4, 3, 608–610Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/om00122a035https://doi.org/10.1021/om00122a035research-articleACS PublicationsRequest reuse permissionsArticle Views538Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties (2012)

Global increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.
Data management issues in cloud integrated computing: A big picture (2017)

Data are of diverse types that are stored and processed in various ways. Data arrive arriving from multiple sources have their own specific attributes and may be static, dynamic or both as time elapse which retains them unique. Data security and data management are the key issues that challenge trusted cloud computing. Security in terms of confidentiality, availability and integrity of data is primary when dealing with voluminous data storage and its transactions. More importantly, cloud data should be protected from malicious attempts that aim at modifying and concealing it even when initiated by malicious service providers themselves. The paper brings out the characteristics of various data forms and their migration to cloud platform. It gives a detail and in-depth literature on taxonomy of data management, issues and approaches to solutions in cloud computing. The paper presents a summary that draws attention to the entities and actors responsible for addressing these issues.
If You Ask Nicely (2018)

Digital home assistants have an increasing influence on our everyday lives. The media now reports how children adapt the consequential, imperious language style when talking to real people. As a response to this behavior, we considered a digital assistant rebuking impolite language. We then investigated how adult users react when being rebuked by the AI. In a between-group study (N = 20), the participants were being rejected by our fictional speech assistant "Eliza" when they made impolite requests. As a result, we observed more polite behavior. Most test subjects accepted the AI's demand and said "please" significantly more often. However, many participants retrospectively denied Eliza the entitlement to politeness and criticized her attitude or refusal of service.
Elevated ras oncogene expression correlates with lymph node metastases in breast cancer patients. (1986)

The protein product of the ras cellular oncogene(s) (p21) was assayed in primary breast carcinomas from two groups of patients who had different axillary lymph node status. Using an immunohistochemical assay, the intensity and percent of neoplastic cells demonstrating ras p21 antigen staining were significantly higher in the primary tumors from patients with lymph nodes positive (LN+) for malignancy (20 patients) compared with the lymph node negative (LNO) group (21 patients). The expression of p21 also correlated with tumor size. Age and estrogen receptor status did not influence p21 staining. The antigen expression of p21 was similar in intensity and distribution in the primary tumor and regional lymph node metastases. Enhanced expression of p21 in primary breast cancers that metastasize to regional nodes indicates that ras p21 may be a determinant of the malignant potential of breast cancer cells and may represent a new class of more biologically relevant tumor markers.
Low-Voltage Highly Linear Floating Gate MOSFET Based Source Degenerated OTA And Its Applications (2018)

The paper proposes a novel low-voltage highly linear floating gate MOSFET based source degenerated OTA. The low voltage operation of the proposed OTA is achieved by using floating gate MOSFETs as input transistors and the linearity is increased by using source degeneration linearization technique. The proposed OTA has low power supply requirement of ±0.6V, rail-to-rail input differential voltage range and wide bandwidth of 1.472 GHz. The applications of the proposed OTA such as active inductor, tunable resistors and filters are also proposed. Finally, the simulation results of the proposed circuits using typical parameters of UMC 0.18μm CMOS technology are depicted to confirm the theoretical analysis.
Junction Temperature Prediction of IGBT Power Module Based on BP Neural Network (2014)

In this paper, the artificial neural network is used to predict the junction temperature of the IGBT power module, by measuring the temperature sensitive electrical parameters (TSEP) of the module. An experiment circuit is built to measure saturation voltage drop and collector current under different temperature. In order to solve the nonlinear problem of TSEP approach as a junction temperature evaluation method, a Back Propagation (BP) neural network prediction model is established by using the Matlab. With the advantages of non-contact, high sensitivity, and without package open, the proposed method is also potentially promising for on-line junction temperature measurement. The Matlab simulation results show that BP neural network gives a more accuracy results, compared with the method of polynomial fitting.
Spin-on Bi4Sr3Ca3Cu4O16+<i>x</i> superconducting thin films from citrate precursors (1988)

Thin films in the Bi-Sr-Ca-Cu-O system have been synthesized from homogeneous liquid citrate precursors by a spin-coating and pyrolysis method. Films prepared on SrTiO3 substrates of [100] orientation show strongly textured orientations with the c axis of the predominant Bi4 Sr3 Ca3 Cu4 O16+x phase normal to the film plane. In a single coating and firing, crack-free films of 0.2–0.5 μm thickness are obtained. For films fired to peak temperatures of 850–875 °C, linearly decreasing resistance with temperature is observed, with ρ (300 K)∼460 μΩ cm and ρ (300 K)/ρ (100 K)∼2.4. Clear onsets of superconductivity are observed at 90–100 K, with occasional films showing smaller resistant drops at 110–120 K. For all films, Tc (R=0) occurs in the range 70–75 K. High critical current densities at 4.2 K of 5–8×105 A/cm2 are measured by direct transport.
Discovering the representative of a search engine (2001)

Given a large number of search engines on the Internet, it is difficult for a person to determine which search engines could serve his/her information needs. A common solution is to construct a metasearch engine on top of the search engines. Upon receiving a user query, the metasearch engine sends it to those underlying search engines which are likely to return the desired documents for the query. The selection algorithm used by a metasearch engine to determine whether a search engine should be sent the query typically makes the decision based on the search-engine representative, which contains characteristic information about the database of a search engine. However, an underlying search engine may not be willing to provide the needed information to the metasearch engine. This paper shows that the needed information can be estimated from an uncooperative search engine with good accuracy. Two pieces of information which permit accurate search engine selection are the number of documents indexed by the search engine and the maximum weight of each term. In this paper, we present techniques for the estimation of these two pieces of information.
Application load imbalance on parallel processors (2002)

This paper addresses the issue of dynamic load imbalance in a class of synchronous iterative applications, and develops a model to represent their workload dynamics. Such models of application load dynamics help in more accurate performance prediction and in the design of efficient load balancing algorithms. Our model captures the workload dynamics across iterations, and predicts the workload distribution at any given iteration as the cumulative effect of workload dynamics during the preceding iterations. The model parameters are derived using empirical data from initial runs of the application. The model development is illustrated using data from a parallel N-body simulation application.
Effect of Gastric Acid on the Pathogenesis of Subglottic Stenosis (1985)

A case of subglottic stenosis, recalcitrant to conventional therapy, was associated with asymptomatic aspiration of gastric acid into the larynx. Once the reflux was controlled by use of an antacid regimen and an H2 blocker, the subglottic stenosis resolved and the patient could be decannulated. This case led to the use of an experimental canine model of subglottic stenosis to examine gastric acid as a pathogenic factor in the development of subglottic stenosis. In control animals, mucosal lesions healed without development of stenosis. In experimental animals with mucosal lesions painted with gastric acid, subglottic stenosis developed. When perichondrium and cartilage were violated and gastric acid applied, stenosis was even more severe and developed more rapidly.
Mesh-based Monte Carlo method using fast ray-tracing in Plücker coordinates (2010)

We describe a fast mesh-based Monte Carlo (MC) photon migration algorithm for static and time-resolved imaging in 3D complex media. Compared with previous works using voxel-based media discretization, a mesh-based approach can be more accurate in modeling targets with curved boundaries or locally refined structures. We implement an efficient ray-tracing technique using Plücker Coordinates. The Barycentric coordinates computed from Plücker-formed ray-tracing enables us to use linear Lagrange basis functions to model both media properties and fluence distribution, leading to further improvement in accuracy. The Plücker-coordinate ray-polygon intersection test can be extended to hexahedral or high-order elements. Excellent agreement is found when comparing mesh-based MC with the analytical diffusion model and 3D voxel-based MC code in both homogeneous and heterogeneous cases. Realistic time-resolved imaging results are observed for a complex human brain anatomy using mesh-based MC. We also include multi-threading support in the software and will port it to a graphics processing unit platform in the near future.
MEASUREMENT OF GLUCOSE TURNOVER IN THE HUMAN NEWBORN WITH GLUCOSE-1-<sup>13</sup>C (1976)

Systemic glucose production rates were measured in 6 normal newborn infants by dilution of glucose-1-13C tracer according to the prime constant-rate infusion technique. Glucose production rates were 4.4 +/- 0.39 mg/kg. min. (Mean +/- S.D.) in 4 infants at 2 hours of age, and were 3.83 and 3.86 mg/kg. min. in 2 infants at 1 day of age. Systemic glucose production accounts for 50% of the substrate utilized for oxidative metabolism in newborn infants.
CAE workstations and semicustom IC vendors offer increased design flexibility (1986)

The advantages of computer-aided engineering (CAE) workstations and a summary of CAE design tasks are reviewed. The incorporation of semicustom integrated circuit (ICs) (gate arrays and standard cells) into the CAE new designs is discussed. To be effective, the design method and the data must be of high quality, and the entire design process must be thoroughly tested. This requires the joint cooperation of the CAE and semicustom VLSI vendors. Because both the design technology and the method are new, designers need a dependable way to learn and use the new tools. The gate array or standard cell design kit is presented as a solution in which the CAE vendor provides the expertise for implementing the design methodology, and the IC vendor provides the expertise for guaranteeing the design data.
Creatine Kinase-MB Elevation After Stroke Is Not Cardiac in Origin (2002)

Troponin T, a more specific biochemical marker of myocardial injury, does not increase after stroke. Normal troponin T along with elevated CK-MB signifies that CK-MB is not the biological marker for myocytolysis. CK-MB elevations in stroke patients are likely to be noncardiac in origin.
COLLEGE OF PHYSICIANS, PHILADELPHIA, SECTION ON OTOLOGY AND LARYNGOLOGY (1925)

<h3>The Practical Value of the Roentgen Ray in Sinus and Mastoid Conditions. Presented by Dr. Fredrick M. Law (by invitation).</h3> By personal contact between the roentgenologist and rhinologist or aurist, much more can be learned from roentgen-ray studies of the sinuses than if a less intimate relation exists. By verbal consultation, the surgeon can make the symptomatology clear in a manner that a written report cannot duplicate. To the interpreter of the roentgen-ray films this information is of extreme value, and only after possessing this knowledge can he properly estimate his findings. Technically perfect films are absolutely essential. A proper reading of such films takes into consideration two main factors: (1) anatomy, and (2) pathology. Of these, the former is the more important; more important because the pathology usually is fairly well understood before films are made, but by an accurate description of anatomic conditions the surgeon will be aided
Transgressive Tapes (1995)

Book Review| January 01 1995 Transgressive Tapes The First Generation: Women and Video, 1970-75 curated by JoAnn Hanley Long, Beach Museum ot Art, Long Beach, CA June 3-August 21, 1994Bad Girls Video, The Wight Gallery UCLA, Los Angeles, CA January 25-March 20, 1994 Jennie Klein Jennie Klein Jennie Klein is finishing her dissertation on feminist video and performance at the University of Southern California. Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1995) 22 (6): 12–13. https://doi.org/10.1525/aft.1995.22.6.12 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jennie Klein; Transgressive Tapes. Afterimage 1 January 1995; 22 (6): 12–13. doi: https://doi.org/10.1525/aft.1995.22.6.12 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1995 by The Regents of the University of California1995 Article PDF first page preview Close Modal You do not currently have access to this content.