gebhart/patrepeval huggingface dataset:
RESEARCH OF THE APPLICATION OF CLINDAMYCIN PHOSPHATE IN THE SUCCESSIVE LUNG INFECTION WITH ANAEROBIC BACTERIA AFTER RADIOTHERAPY (2000)

目的:探讨克林霉素磷酸酯对恶性肿瘤放疗后继发肺部厌氧菌感染的治疗疗效及不良反应.材料和方法:78例肺部接受过放射治疗的恶性肿瘤患者肺部继发厌氧菌感染随机分为克林霉素磷酸酯治疗组(实验组)41例和甲硝唑治疗组(对照组)37例.克林霉素磷酸酯,每次300～600 mg,每日2～3次,疗程10～14 d.甲硝唑,每次500～750 mg,每日2次或每8 h 1次,疗程10～14 d.结果:(1)实验组痊愈率为68.3%,对照组为45.9%,P<0.05,有效率分别为80.5%,59.5%,P<0.05;(2)实验组致病菌清除率为75.6%,对照组为54.1%,P<0.05,;(3)不良反应发生率实验组为22%,对照组为45.9%,P<0.05.结论:克林霉素磷酸酯对肺部放疗后继发肺部厌氧菌感染的治疗疗效好、副作用低.
Left ventricular length dependent activation in the isovolumetric rat heart (1990)

The results show, as in isolated preparations, that there is length dependent activation in the whole rat heart.
Knowledge acquisition: issues, techniques, and methodology (1990)

Article Free Access Share on Knowledge acquisition: issues, techniques, and methodology Author: Yihwa Irene Liou Information and Quantitative Sciences Department, Merrick School of Business, University of Baltimore, Baltimore, Maryland Information and Quantitative Sciences Department, Merrick School of Business, University of Baltimore, Baltimore, MarylandView Profile Authors Info & Claims SIGBDP '90: Proceedings of the 1990 ACM SIGBDP conference on Trends and directions in expert systemsSeptember 1990 Pages 212–236https://doi.org/10.1145/97709.97726Published:01 September 1990Publication History 18citation3,291DownloadsMetricsTotal Citations18Total Downloads3,291Last 12 Months1,067Last 6 weeks282 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Neurobiology of Non-REM Sleep in Depression: Further Evidence for Hypofrontality and Thalamic Dysregulation (2004)

Patterns of relative regional cerebral glucose metabolism changes from presleep wakefulness to non-REM sleep differ in healthy subjects and depressed patients. Specifically, the transition from wakefulness to non-REM sleep was characterized by the relative persistence of elevated metabolic activity in frontoparietal regions and thalamus in depressed patients compared with healthy subjects. These findings suggest that abnormal thalamocortical network function may underlie sleep anomalies and complaints of nonrestorative sleep in depressed patients.
Type 2C protein phosphatases in plants (2012)

Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg(2+)-/Mn(2+)-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.
<i>De novo</i> designed peptide-based amyloid fibrils (2002)

Identification of therapeutic strategies to prevent or cure diseases associated with amyloid fibril deposition in tissue (Alzheimer's disease, spongiform encephalopathies, etc.) requires a rational understanding of the driving forces involved in the formation of these organized assemblies rich in beta-sheet structure. To this end, we used a computer-designed algorithm to search for hexapeptide sequences with a high propensity to form homopolymeric beta-sheets. Sequences predicted to be highly favorable on this basis were found experimentally to self-associate efficiently into beta-sheets, whereas point mutations predicted to be unfavorable for this structure inhibited polymerization. However, the property to form polymeric beta-sheets is not a sufficient requirement for fibril formation because, under the conditions used here, preformed beta-sheets from these peptides with charged residues form well defined fibrils only if the total net charge of the molecule is +/-1. This finding illustrates the delicate balance of interactions involved in the formation of fibrils relative to more disordered aggregates. The present results, in conjunction with x-ray fiber diffraction, electron microscopy, and Fourier transform infrared measurements, have allowed us to propose a detailed structural model of the fibrils.
Microstructured polymer optical fibre (2001)

The first microstructured polymer optical fibre is described. Both experimental and theoretical evidence is presented to establish that the fibre is effectively single moded at optical wavelengths. Polymer-based microstructured optical fibres offer key advantages over both conventional polymer optical fibres and glass microstructured fibres. The low-cost manufacturability and the chemical flexibility of the polymers provide great potential for applications in data communication networks and for the development of a range of new polymer-based fibre-optic components.
Conformational analysis. XXIV. Effect of dipolar and eclipsing forces on intramolecular hydrogen bonding in 3-hydroxymethyltetrahydropyran and 5-hydroxymethyl-1,3-dioxane (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational analysis. XXIV. Effect of dipolar and eclipsing forces on intramolecular hydrogen bonding in 3-hydroxymethyltetrahydropyran and 5-hydroxymethyl-1,3-dioxaneErnest L. Eliel and Harold D. BanksCite this: J. Am. Chem. Soc. 1972, 94, 1, 171–176Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://doi.org/10.1021/ja00756a029RIGHTS & PERMISSIONSArticle Views359Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (745 KB) Get e-Alerts Get e-Alerts
A possible role for plasmalogens in protecting animal cells against photosensitized killing. (1988)

Chinese hamster ovary (CHO) cells incorporate 12-(1'-pyrene) dodecanoic acid (P12) into membrane lipids. Exposure of P12-labeled cells to long wavelength ultraviolet light causes cell killing, presumably because excitation of the pyrene moiety (a photosensitizer) leads to the generation of reactive oxygen species. Cytotoxicity is dependent upon the concentration of P12 used to label the cells, and time of UV exposure, and the presence of oxygen during irradiation. CHO mutant cells deficient in plasmalogen biosynthesis and peroxisome assembly (Zoeller, R.A., and Raetz, C.R.H. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 5170-5174) are several orders of magnitude more sensitive to P12/UV treatment than wild-type cells, permitting direct selection of one wild-type cell in 1 X 10(4) mutant cells. A major factor responsible for the P12/UV hypersensitivity of these mutants appears to be the absence of plasmalogens. Supplementation of the mutants with 1-O-hexadecyl-sn-glycerol restores plasmalogen levels and nearly normal resistance to P12/UV treatment, whereas the biogenesis of peroxisomes is not restored. The P12/UV hypersensitivity of the plasmalogen-deficient mutants, together with the selective, P12/UV-induced decomposition of plasmalogens in wild-type cells, documented in the accompanying manuscript, suggest that the vinyl ether linkage of plasmalogens plays a direct role in protecting animal cell membranes against certain oxidative stresses.
Mobile IP Network Access Identifier Extension for IPv4 (2000)

AAA servers are in use within the Internet today to provide authentication and authorization services for dial-up computers.Such services are likely to be equally valuable for mobile nodes using Mobile IP when the nodes are attempting to connect to foreign domains with AAA servers.AAA servers today identify clients by using the Network Access Identifier (NAI).Our proposal defines a way for the mobile node to identify itself, by including the NAI along with the Mobile IP Registration Request.This memo also updates RFC 2290 which specifies the Mobile-IPv4 Configuration option for IPCP, by allowing the Mobile Node's Home Address field of this option to be zero.
Cathodic deposition of interlaced nanosheet-like cobalt sulfide films for high-performance supercapacitors (2012)

In this study, an interlaced nanosheet-like cobalt sulfide (CoS) electroactive material was deposited on a Ni foam substrate using a facile and efficient electrochemical route and employed as a high-performance supercapacitor for the first time. An impressive specific capacitance, as high as 1471 F g−1 at 4 A g−1, was achieved for the interlaced nanosheet-like CoS electroactive material in 1.0 M KOH aqueous electrolyte. It delivered a remarkable specific capacitance of up to 1306 F g−1 even at a high charge–discharge current density of 40 A g−1, indicating its excellent energy storage at high rates. Moreover, nearly 100% retention of specific capacitance and >99% Coulombic efficiency were achieved even after consecutive 1000 cycles with a fairly high current density of 8 A g−1.
Effects of growth factors on myogenic differentiation (1989)

It has now been well established that the terminal differentiation of muscle cells in culture is subject to control by hormones and growth factors in the incubation medium. Thus far the most potent and most extensively studied agents are fibroblast growth factor (FGF), the insulinlike growth factors (IGFs), and transforming growth factor-beta (TGF-beta). Independent reports from several laboratories have established that both FGF and TGF-beta are potent inhibitors of differentiation and both appear to act at early stages of commitment to differentiation. Stimulation of differentiation by the IGFs (and by insulin at concentrations in the microgram/ml range) has also been observed and confirmed repeatedly. FGF and IGF are mitogenic for muscle cells, and TGF-beta either has no effect or suppresses cell proliferation, so previous generalizations that mitogens inhibit myogenic differentiation are clearly not valid when results with purified agents in well-defined media are considered. Work with oncogenes and specific toxins is beginning to reveal the mechanisms by which these agents might affect differentiation, and there is reason for optimism that an understanding of the molecular events that control terminal differentiation may be attained in the near future.
The Colour Triangle (2004)

This chapter contains sections titled: Introduction Colour terminology Trichromatic matching Colour-matching functions The colour triangle The centre of gravity law Other colour triangles Additive colour reproduction The Ives-Abney-Yule compromise Colour gamuts of reflecting and transmitting colours Two-colour reproductions
A stochastic model of self‐renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture (1982)

We recently identified a murine hemopoietic stem cell colony which consists of undifferentiated (blast) cells and appears to be more primitive than CFU-GEMM in the stem cell hierarchy. The progenitors for the colony which we termed "stem cell colony" possess an extensive self-renewal capacity and the ability to generate many secondary multipotential hemopoietic colonies in culture. We replated a total of 68 stem cell colonies from cultures of murine spleen cells and analyzed the number of stem cell--and granulocyte(neutrophil)-erythrocyte-macrophage-megakaryocyte (GEMM) colony-forming cells in individual stem cell colonies. Of the 68 stem cell colonies, 35 contained progenitors (abbreviated as "S"-cells) for stem cell colonies. The distributions of S-cells and CFU-GEMM in individual stem cell colonies were extremely heterogeneous. Neither the frequency distributions of S-cells nor CFU-GEMM in stem cell colonies could be fitted well by Poisson distribution. Rather, the frequency distribution of the s-cells could be approximated by a geometric distribution and that of CFU-GEMM by an exponential distribution, both of which are variates of the gamma distribution. Our observations are in agreement with those on the distributions of CFU-S in individual spleen colonies and provided support for a stochastic model for stem cell self-renewal and commitment in culture. Application of the theory of the branching process to the distribution of S-cells revealed a distributional parameter "p" of 0.589 which is also in agreement with the earlier report on the p value for reproduction of CFU-S.
Nuclear Magnetic Resonance Studies of Cancer. V. Appearance and Development of a Tumor Systemic Effect in Serum and Tissues 2 (1974)

Journal Article Nuclear Magnetic Resonance Studies of Cancer. V. Appearance and Development of a Tumor Systemic Effect in Serum and Tissues Get access Donald P. Hollis, Donald P. Hollis 3Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Md. 21205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Leon A. Saryan, Leon A. Saryan 3Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Md. 21205. Search for other works by this author on: Oxford Academic PubMed Google Scholar James S. Economou, James S. Economou 3Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Md. 21205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph C. Eggleston, Joseph C. Eggleston 5Department of Pathology, The Johns Hopkins University School of Medicine. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeffrey L. Czeisler, Jeffrey L. Czeisler 3Department of Physiological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Md. 21205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold P. Morris Harold P. Morris 6Department of Biochemistry, Howard University College of Medicine, Washington, D.C. 20001. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 3, September 1974, Pages 807–815, https://doi.org/10.1093/jnci/53.3.807 Published: 01 September 1974 Article history Received: 26 February 1974 Accepted: 30 May 1974 Published: 01 September 1974
Novel Triglycerides for Special Medical Purposes (1988)

The clinical use of intravenous lipid emulsions have been routine for over 25 years. For most of that time period the use of the vegetable oils, soybean and safflower, were the exclusive lipid source for these emulsions. Recently intravenous medium-chain triglycerides have been commercially available. This review will discuss several important new research developments coming from the laboratory which should prove to enhance the nutritional effectiveness as well as minimize the adverse effects of lipid emulsions. The use of medium-chain triglycerides either enterally or parenterally has shown them to be superior energy sources when compared to long-chain triglycerides. Under experimental conditions of burn injury, their support of certain aspects of protein metabolism is superior to that of the current emulsions. This may be due to their rapid and preferential oxidation and poor storage into adipose tissue, and increased thermogenesis which has been observed from either enteral or parenteral administration in humans. This increased metabolic rate is not accompanied by an increase in temperature. Lipid emulsions have been described as having many different effects on variable aspects of the immunologic system. Some of these could be considered to be beneficial or without harm, and others are considered potentially deleterious. We have focused on the effects of parenteral lipid emulsions, in animals as well as in humans, on the function of the reticuloendothelial system.(ABSTRACT TRUNCATED AT 250 WORDS)
Progressive Coding and Illumination and View Dependent Transmission of 3-D Meshes Using R-D Optimization (2010)

For transmitting complex 3-D models over bandwidth-limited networks, efficient mesh coding and transmission are indispensable. The state-of-the-art 3-D mesh transmission system employs a wavelet-based progressive mesh coder, which converts an irregular mesh into a semi-regular mesh and directly applies the zerotree-like image coders to compress the wavelet vectors, and view-dependent transmission, which saves the transmission bandwidth through only delivering the visible portions of a mesh model. We propose methods to improve both progressive mesh coding and transmission based on thorough rate-distortion analysis. In particular, by noticing that the dependency among the wavelet coefficients generated in remeshing is not being considered in the existing approaches, we propose to introduce a preprocessing step to scale up the wavelets so that the inherent dependency of wavelets can be truly understood by the zerotree-like image compression algorithms. The weights used in the scaling process are carefully designed through thoroughly analyzing the distortions of wavelets at different refinement levels. For the transmission part, we propose to incorporate the illumination effects into the existing view-depend progressive mesh transmission system to further improve the performance. We develop a novel distortion model that considers both illumination distortion and geometry distortion. Based on our proposed distortion model, given the viewing and lighting parameters, we are able to optimally allocate bits among different segments in real time. Simulation results show significant improvements in both progressive compression and transmission.
Reductive Addition of Alkyl Radical to Phenyl Vinyl Sulfone (1992)

Abstract Radicals generated from (diacyloxyiodo)benzene readily added to phenyl vinyl sulfone to give 2-alkylethyl phenyl sulfone in the presence of a hydrogen donor such as 1,4-cyclohexadiene, 1,3-dioxolane, or triethylsilane. Among these donors, 1,4-cyclohexadiene was the most effective.
Handheld System Design for Dual-Eye Multispectral Iris Capture With One Camera (2013)

This paper describes the design and implementation of a dual-eye multispectral iris capture handheld device with one camera, which consists of the following four parts: 1) capture unit; 2) illumination unit; 3) interaction unit; and 4) control unit. A multispectral iris image database is created by the proposed capture device, and then, we use the multispectral score-level fusion to further investigate the effectiveness of the proposed capture device by the 1-D Log-Gabor wavelet filter approach. Experimental results are also presented in this paper.
Cu II laser with a helical hollow cathode discharge (1983)

A novel design of a water-cooled helical hollow cathode device (HCD) is presented. The simple construction, that is conveniently manufactured, offers discharge and laser properties superior to those obtained with conventional HCDs. This is demonstrated for a CW IR Cu II laser.
Fast phase processing in off-axis holography by CUDA including parallel phase unwrapping (2016)

We present parallel processing implementation for rapid extraction of the quantitative phase maps from off-axis holograms on the Graphics Processing Unit (GPU) of the computer using computer unified device architecture (CUDA) programming. To obtain efficient implementation, we parallelized both the wrapped phase map extraction algorithm and the two-dimensional phase unwrapping algorithm. In contrast to previous implementations, we utilized unweighted least squares phase unwrapping algorithm that better suits parallelism. We compared the proposed algorithm run times on the CPU and the GPU of the computer for various sizes of off-axis holograms. Using the GPU implementation, we extracted the unwrapped phase maps from the recorded off-axis holograms at 35 frames per second (fps) for 4 mega pixel holograms, and at 129 fps for 1 mega pixel holograms, which presents the fastest processing framerates obtained so far, to the best of our knowledge. We then used common-path off-axis interferometric imaging to quantitatively capture the phase maps of a micro-organism with rapid flagellum movements.
Estrogen receptor determination in fine needle aspirates of the breast. Correlation with histologic grade and comparison with biochemical analysis. (1987)

Material obtained by fine needle aspiration (FNA) of 25 surgically removed breast carcinomas was tested for the immunocytochemical localization of estrogen receptor (ER) using the peroxidase-antiperoxidase method and a monoclonal antibody developed against human breast cancer ER. The results were compared to those obtained by the conventional biochemical analysis of cytosol protein. A semiquantitative relationship between the immunoperoxidase stain and the biochemical analysis suggests that cases in which greater than 70% of the cells stain and in which intense staining is present are likely to contain ER in a concentration of greater than 250 fmol/mg of cytosol. Less than 15% stained cells and an absence of intense staining is indicative of a concentration of less than 10 fmol/mg. In only one case was there a significant difference in positivity between the two methods, possibly as a result of a functional heterogeneity of the tumor cell population. Intense staining is strongly suggestive of a tumor of low histologic grade and was never seen in tumors with a high histologic grade or nuclear grade. The immunoperoxidase method of ER detection on material obtained by FNA is a semiquantitative means of selecting patients with breast cancer who are likely to respond to hormonal therapy. The method overcomes many important disadvantages of cytosol analysis and provides clinically significant information regarding the ER content and the degree of tumor differentiation.
Direct Cortical Representation of Drawing (1994)

How the intention to act results in movement is a fundamental question of brain organization. Recent work has shown that this operation involves the cooperative interaction of large neuronal populations. A population vector method, by transforming neuronal activity to the spatial domain, was used to visualize the motor cortical representation of the hand's trajectory made by rhesus monkeys as they drew spirals. Hand path was accurately reflected by a series of population vectors calculated throughout the task. A psychophysical rule relating speed to curvature, the "power law," was found in this cortical representation. The relative timing between each population vector and the corresponding portion of the movement was variable. The population vectors only preceded the movement in a predictive manner in portions of the spiral where the radius of curvature was greater than 6 centimeters. These results show that the movement trajectory is an important determinant of motor cortical activity and that this aspect of motor cortical activity may contribute only to discrete portions of the drawing movement.