gebhart/patrepeval huggingface dataset:
Lysine and Arginine Side Chains in Glycosaminoglycan−Protein Complexes Investigated by NMR, Cross-Linking, and Mass Spectrometry: A Case Study of the Factor H−Heparin Interaction (2010)

We have used the interaction between module 7 of complement factor H (CFH approximately 7) and a fully sulfated heparin tetrasaccharide to exemplify a new approach for studying contributions of basic side chains to the formation of glycosaminoglycan (GAG)-protein complexes. We first employed HISQC and H(2)CN NMR experiments to monitor the side-chain resonances of lysines and arginines in (15)N, (13)C-labeled protein during titrations with a fully sulfated heparin tetrasaccharide under physiological conditions. Under identical conditions and using (15)N-labeled protein, we then cross-linked tetrasaccharide to CFH approximately 7 and confirmed the 1:1 stoichiometry by FT-ICR-MS. We subsequently characterized this covalent protein-GAG conjugate by NMR and further MS techniques. MALDI-TOF MS identified protein fragments obtained via trypsin digestion or chemical fragmentation, yielding information concerning the site of GAG attachment. Combining MS and NMR data allowed us to identify the side chain of K405 as the point of attachment of the cross-linked heparin oligosaccharide to CFH approximately 7. On the basis of the analysis of NMR and MS data of the noncovalent and cross-linked CFH approximately 7-tetrasaccharide complexes, we conclude that the K446 side chain is not essential for binding the tetrasaccharide, despite the large chemical shift perturbations of its backbone amide (15)N and (1)H resonances during titrations. We show that R444 provides the most important charge-charge interaction within a C-terminal heparin-binding subsite of CFH approximately 7 whereas side chains of R404, K405, and K388 are the predominant contributors to an N-terminal binding subsite located in the immediate vicinity of residue 402, which is implicated in age-related macular degeneration (AMD).
Genetic Control of Carbon Partitioning in Grasses: Roles of <i>Sucrose Transporters</i> and <i>Tie-dyed</i> Loci in Phloem Loading  (2009)

Plants have specialized organs for distinct functions. Leaves perform photosynthesis and fix carbon, whereas roots absorb water and minerals. To distribute resources between these organs, plants have a vasculature composed of phloem and xylem. The xylem conducts water and minerals from the roots up
Electrical and structural investigation of triangular defects in 4H-SiC junction barrier Schottky devices (2009)

The structure and effects of triangular-shaped defects in 4H-SiC junction barrier Schottky devices were investigated using I-V measurements, infrared microscopy, electron beam induced current, electroluminescence, and transmission electron microscopy. Thermal imaging of devices under reverse bias detected hot spots at the locations of triangular defects. Electroluminescence images determined the position of the leakage currents at the triangular defect sides near the p-n metallurgical junction. The triangular defects consist of macroscopic (1 μm thick) 3C-SiC platelets embedded in the 4H-SiC matrix.
The use of fluorogenic peptide substrates for the detection of coagulation factors II and X after electrophoresis (1982)

Summary The use of synthetic oligopeptides with a fluorescent detector group for the localization of thrombin and activated factor X activity after electrophoresis is described. This new technique provides high specificity and resolution. This approach to the detection of blood coagulation factors II and X can be extended to other factors, where their specific peptide cleavage sequence is known.
Resolution recommendation for event tickets in service management (2015)

In recent years, IT Service Providers have been rapidly transforming to an automated service delivery model. This is due to advances in technology and driven by the unrelenting market pressure to reduce cost and maintain quality. Tremendous progress has been made to date towards attainment of truly automated service delivery; that is, the ability to deliver the same service automatically using the same process with the same quality. However, automating Incident and Problem Management continuous to be a difficult problem, particularly due to the growing complexity of IT environments. Software monitoring systems are designed to actively collect and signal event occurrances and, when necessary, automatically generate incident tickets. Repeating events generate similar tickets, which in turn have a vast number of repeated problem resolutions likely to be found in earlier tickets. In this paper we find an appropriate resolution by making use of similarities between the events and previous resolutions of similar events. Traditional KNN (K Nearest Neighbor) algorithm has been used to recommend resolutions for incoming tickets. However, the effectiveness of recommendation heavily relies on the underlying similarity measure in KNN. In this paper, we significantly improve the similarity measure used in KNN by utilizing both the event and resolution information in historical tickets via a topic-level feature extraction using the LDA (Latent Dirichlet Allocation) model. In addition, when resolution categories are available, we propose to learn a more effective similarity measure using metric learning. Extensive empirical evaluations on three ticket data sets demonstrate the effectiveness and efficiency of our proposed methods.
Simultaneous Optimization of Geometry and Firing Angles for In-Wheel Switched Reluctance Motor Drive (2017)

Interests in using rare-earth free motors such as switched reluctance motors (SRMs) for electric and hybrid electric vehicles continue to gain popularity, owing to their low cost and robustness. Optimal design of an SRM, to meet specific characteristics for an application, should involve simultaneous optimization of the motor geometry and control in order to achieve the highest performance with the lowest cost. This paper presents a constrained multiobjective optimization framework for design and control of an SRM based on a nondominated sorting genetic algorithm II. The proposed methodology optimizes SRM operation for high volume traction applications by considering multiple criteria including efficiency, average torque, and torque ripple. Several constraints are defined by the considered application, such as the motor stack length, outer diameter, minimum operating power, minimum desired efficiency, rated speed, rated current, and supply voltage. The outcome of this optimization includes an optimal geometry, outlining variables such as air gap length, rotor inner diameter, stator pole arc angle, rotor pole arc angle, rotor back iron, stator pole height, and stator inner diameter as well as optimal turn-on and turn-off firing angles. Then the machine is manufactured according to the obtained optimal specifications. Comprehensive finite-element analysis and experimental results are provided to validate the theoretical findings.
Meta-Optics with Mie Resonances (2017)

Optical magnetic responses and subwavelength localization of light, driven by Mie resonances in high-index nanoparticles, could spur new, breakthrough applications for nanoantennas, nanolasers, highly efficient metasurfaces and ultrafast meta­devices.
Social Commerce: A Contingency Framework for Assessing Marketing Potential (2013)

A key issue for marketers resulting from the dramatic rise of social media is how it can be leveraged to generate value for firms. Whereas the importance of social media for brand management and customer relationship management is widely recognized, it is unclear whether social media can also help companies market and sell products. Extant discussions of social commerce present a variety of perspectives, but the core issue remains unresolved. This paper aims to make two contributions. First, to address the lack of clarity in the literature regarding the meaning and domain of social commerce, the paper offers a definition stemming from important research streams in marketing. This definition allows for both a broad (covering all steps of the consumer decision process) and a narrow (focusing on the purchase act itself) construal of social commerce. Second, we build on this definition and develop a contingency framework for assessing the marketing potential that social commerce has to offer to firms. Implications for researchers and managers, based on the proposed definition and framework, are also discussed.
Novel poly(vinyl alcohol)-based amphiphilic nanogels by non-covalent boric acid crosslinking of polymeric micelles (2017)

In this work, we report a new type of poly(vinyl alcohol)-g-poly(N-isopropylacrylamide) (PVA-g-PNiPAAm) amphiphilic nanogel produced by the non-covalent crosslinking of PVA polyol domains in preformed polymeric micelles with boric acid. The nanomaterials showed sizes in the 100-250 nm range (DLS) and a spherical morphology (HR-SEM). We demonstrated that the size of the polymeric micelles could be fine-tuned by changing the concentration (and the aggregation pattern) of the polymeric amphiphile in water. Upon crosslinking, the polymeric micelles turned into physically stable amphiphilic nanogels that displayed both size and size distribution similar to the micellar precursor for up to two weeks, even under disfavored conditions of concentration and temperature that, in the case of non-crosslinked counterparts, resulted in quick disassembly. In addition, we show for the first time the feasibility of spray-drying technology to consolidate the 3D network formed between PVA and boric acid and to produce stable powders that can be reconstituted upon use at any desired concentration. Moreover, the formation of a borated surface conferred the nanogels with good mucoadhesiveness in vitro. Finally, these novel nanomaterials showed optimal cell compatibility in a model of the intestinal epithelium, the Caco2 cell line. Overall results demonstrate the unprecedented versatility of the proposed modular approach and opens completely new horizons in the application of polymeric micelles and other self-assembled polymeric nanomaterials in diagnostics and therapeutics.
D<sup>3</sup>: Abnormal driving behaviors detection and identification using smartphone sensors (2015)

Real-time abnormal driving behaviors monitoring is a corner stone to improving driving safety. Existing works on driving behaviors monitoring using smartphones only provide a coarsegrained result, i.e. distinguishing abnormal driving behaviors from normal ones. To improve drivers' awareness of their driving habits so as to prevent potential car accidents, we need to consider a finegrained monitoring approach, which not only detects abnormal driving behaviors but also identifies specific types of abnormal driving behaviors, i.e. Weaving, Swerving, Sideslipping, Fast U-turn, Turning with a wide radius and Sudden braking. Through empirical studies of the 6-month driving traces collected from real driving environments, we find that all of the six types of driving behaviors have their unique patterns on acceleration and orientation. Recognizing this observation, we further propose a finegrained abnormal Driving behavior Detection and iDentification system, D <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> , to perform real-time high-accurate abnormal driving behaviors monitoring using smartphone sensors. By extracting unique features from readings of smartphones' accelerometer and orientation sensor, we first identify sixteen representative features to capture the patterns of driving behaviors. Then, a machine learning method, Support Vector Machine (SVM), is employed to train the features and output a classifier model which conducts fine-grained identification. From results of extensive experiments with 20 volunteers driving for another 4 months in real driving environments, we show that D <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> achieves an average total accuracy of 95.36%.
Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders (2015)

Research in the genetics of neurodevelopmental disorders such as autism suggests that several hundred genes are likely risk factors for these disorders. This heterogeneity presents a challenge and an opportunity at the same time. Although the exact identity of many of the genes remains to be discovered, genes identified to date encode proteins that play roles in certain conserved pathways: protein synthesis, transcriptional and epigenetic regulation, and synaptic signaling. The next generation of research in neurodevelopmental disorders must address the neural circuitry underlying the behavioral symptoms and comorbidities, the cell types playing critical roles in these circuits, and common intercellular signaling pathways that link diverse genes. Results from clinical trials have been mixed so far. Only when we can leverage the heterogeneity of neurodevelopmental disorders into precision medicine will the mechanism-based therapeutics for these disorders start to unlock success.
A new degradation mode of scaled p/sup +/ polysilicon gate pMOSFETs induced by bias temperature (BT) instability (2002)

A new degradation mode induced by bias temperature (BT) instability is found in short channel p/sup +/ polysilicon gate (p/sup +/-gate) pMOSFETs. This instability, i.e. negative threshold voltage shift, increases significantly by reducing gate length due to the local degradation of gate oxide near the source/drain (S/D) edge, as a result of the electrochemical reaction between holes and oxide defects. This degradation is enhanced by boron penetration through the oxide from the p/sup +/-gate peculiar to p/sup +/-gate MOS structures. These results indicate that it is important to suppress BT instability of p/sup +/-gate pMOSFETs for scaling down CMOS devices.
A Monoclonal Antibody Against Bovine Thrombin Reacting to the C-Terminal Side of Thrombin (2001)

We succeeded in producing a monoclonal antibody (MAb) against bovine thrombin. The MAb belonged to mouse IgG1, and its light chain consisted of κ-chain. The MAb reacted with bovine and human thrombins, which were coated by coupling to poly-lysine-coated wells with glutaraldehyde, but did not react with the thrombin-like enzyme, habutobin. Furthermore, the MAb did not react with thrombin which was coated to plates without poly-lysine and glutaraldehyde. The concentration of thrombin in ovalbumin solution (10 mg/mL) could be measured by means of the enzyme-linked immunosorbent assay (ELISA) double sandwich method using the MAb and polyclonal antibody. Thrombin added to defibrinated plasma could not be detected by means of the ELISA double sandwich method using the present MAb, and this may be due to the AT-III activity in the defibrinated plasma. Postclotting thrombin could be detected by means of the ELISA-double sandwich method using the MAb. It is suggested, from the results of our experiments, that the MAb obtained reacted in a limited fashion to the C-terminal of bovine thrombin.
Modeling of the Oxidation of Primary Reference Fuel in the Presence of Oxygenated Octane Improvers: Ethyl Tert-Butyl Ether and Ethanol (2007)

A detailed chemical kinetic mechanism has been developed for the oxidation of primary reference fuel (PRF, mixture of n-heptane and iso-octane) in the presence of ethyl tert-butyl ether (ETBE) or ethanol. The mechanism was validated by comparison with the existing experimental data from shock tubes, a jet-stirred reactor, and a flow reactor. ETBE and ethanol are known as octane number improvers. Enhancement of research octane number (RON) by the addition of ETBE and ethanol to PRF has been measured using a cooperative fuel research (CFR) engine. Increase in RON was simulated with the present detailed kinetic mechanism by estimating the critical compression ratio (CCR) for autoignition in a motored engine. The correlation curve between CCR and RON was derived by calculating the CCR for PRF whose composition defines the RON. The kinetic model reproduces observed variations in RON by the addition of ETBE and ethanol to PRF. Those additives showed a very similar effect on RON.
<i>O</i>-Carboxymethyl−Chitin Concentration in Granulocytes during Bone Repair (2001)

Peroral and intravenous administrations of (14)C-labeled carboxymethyl-chitin (CM-chitin) revealed that CM-chitin accumulated in bone marrow. Thus, a composite of CM-chitin with hydroxyapatite (HA) was prepared to examine the bone repairing properties by animal and cell line experiments. The new bone formation of CM-chitin.HA composite was superior to that of CM-chitin, HA, and blank. A porous CM-chitin.HA composite is a functional material which could act as a scaffolding of osteoblast-like cells, a barrier to ingrowth of fibrous connective tissues. The cytotoxicity of CM-chitin was evaluated using the MC3T3-E1 cell line, and we found that control of degree of deacetylation is a very important factor in using CM-chitin as bone repairing material.
Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice. (1994)

The strategic location of mast cells at the host-environment interface and their ability to release potent mediators of inflammation have suggested that these cells may play a pivotal role in host defense against bacterial infection. The ability of the opportunistic pathogen, Escherichia coli, to induce degranulation of mast cells obtained from the mouse peritoneum was investigated. We determined that unlike a mutant derivative deficient in the FimH subunit of the fimbriae or nonfimbriated E. coli, type 1 fimbriated E. coli induced mast cell degranulation in vitro. The magnitude of mast cell degranulation was directly proportional to the number of adherent bacteria on the cell surface in the initial period of the interaction. Using a mouse model of bacterial peritonitis, we demonstrated mast cell degranulation and histamine release by type 1 fimbriated bacteria in vivo. Furthermore, beads coated with FimH but not with FimA, the major subunit of type 1 fimbriae, evoked mast cell release of histamine in vivo in amounts comparable to that elicited by type 1 fimbriated E. coli. These studies reveal that mast cells can be degranulated by interaction with type 1 fimbriated E. coli and that FimH, the mannose-binding component of the fimbriae, is a potent mast cell stimulant.
An Implantable Subcutaneous Glucose Sensor Array in Ketosis‐prone Rats: Closed Loop Glycemic Control (2005)

A closed loop system of diabetes control would minimize hyperglycemia and hypoglycemia. We therefore implanted and tested a subcutaneous amperometric glucose sensor array in alloxan-diabetic rats. Each array employed four sensing units, the outputs of which were processed in real time to yield a unified signal. We utilized a gain-scheduled insulin control algorithm which rapidly reduced insulin delivery as glucose concentration declined. Such a system was generally effective in controlling glycemia and the degree of lag between blood glucose and the sensor signal was usually 3-8 min. After prolonged implantation, this lag was sometimes longer, which led to impairment of sensor accuracy. Using a prospective two-point calibration method, sensor accuracy and closed loop control were good. A revised algorithm yielded better glycemic control than the initial algorithm did. Future research needs to further improve calibration methods and reduce foreign body fibrosis in order to avoid a time-related increase in lag duration.
Combustion (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCombustionBernard. Lewis and Guenther Von. ElbeCite this: Ind. Eng. Chem. 1951, 43, 9, 1925–1941Publication Date (Print):September 1, 1951Publication History Published online1 May 2002Published inissue 1 September 1951https://pubs.acs.org/doi/10.1021/ie50501a013https://doi.org/10.1021/ie50501a013research-articleACS PublicationsRequest reuse permissionsArticle Views396Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase (2000)

Angiogenesis, the formation of new capillaries from preexisting blood vessels, is a multistep, highly orchestrated process involving vessel sprouting, endothelial cell migration, proliferation, tube differentiation, and survival. Eicosanoids, arachidonic acid (AA)-derived metabolites, have potent biologic activities on vascular endothelial cells. Endothelial cells can synthesize various eicosanoids, including the 12-lipoxygenase (LOX) product 12(S)-hydroxyeicosatetraenoic acid (HETE). Here we demonstrate that endogenous 12-LOX is involved in endothelial cell angiogenic responses. First, the 12-LOX inhibitor, N-benzyl-N-hydroxy-5-phenylpentanamide (BHPP), reduced endothelial cell proliferation stimulated either by basic fibroblast growth factor (bFGF) or by vascular endothelial growth factor (VEGF). Second, 12-LOX inhibitors blocked VEGF-induced endothelial cell migration, and this blockage could be partially reversed by the addition of 12(S)-HETE. Third, pretreatment of an angiogenic endothelial cell line, RV-ECT, with BHPP significantly inhibited the formation of tubelike/cordlike structures within Matrigel. Fourth, overexpression of 12-LOX in the CD4 endothelial cell line significantly stimulated cell migration and tube differentiation. In agreement with the critical role of 12-LOX in endothelial cell angiogenic responses in vitro, the 12-LOX inhibitor BHPP significantly reduced bFGF-induced angiogenesis in vivo using a Matrigel implantation bioassay. These findings demonstrate that AA metabolism in endothelial cells, especially the 12-LOX pathway, plays a critical role in angiogenesis.
Evidence for temporal processing deficits in children with attention deficit hyperactivity disorder and language impairments on a dichotic listening task (1998)

This study examineci the effeas of language hpairrnents (LI) in children with attention deficit hyperactivity disorder (ADHD) on a dichotic tistening task.A total sample of 53 children, aged 7 to 1 1 years, participated in the study: 20 met diagnostic criteria for ADHD, 18 met the diagnosis for A D W L I , and 15 normai controls.Ail children were required to distinguish between phonetically similar words and emotionai tones.Repeated measures aoalysis of variance were used to adyze the data.The analyses indicated that children with language impainnents had signifiant difliculties discriminating targets compared to ADHD children and controls, who did not Mer.This data suggests that children with ADHD and concurrent language impairments have difEculty processing the acoustic signal required for the perception of speech and tonal patterns.This difEnilty may result f?om more basic temporal processing deficits which interferes with the resolution of brief shdtaneous presentation of stimuli.16 19
Efficient Interferer Cancelation Based On Geometrical Information Of The Reverberant Environment (2008)

Publication in the conference proceedings of EUSIPCO, Lausanne, Switzerland, 2008