gebhart/patrepeval huggingface dataset:
When Point Process Meets RNNs: Predicting Fine-Grained User Interests with Mutual Behavioral Infectivity (2017)

Predicting fine-grained interests of users with temporal behavior is important to personalization and information filtering applications. However, existing interest prediction methods are incapable of capturing the subtle degreed user interests towards particular items, and the internal time-varying drifting attention of individuals is not studied yet. Moreover, the prediction process can also be affected by inter-personal influence, known as behavioral mutual infectivity. Inspired by point process in modeling temporal point process, in this paper we present a deep prediction method based on two recurrent neural networks (RNNs) to jointly model each user's continuous browsing history and asynchronous event sequences in the context of inter-user behavioral mutual infectivity. Our model is able to predict the fine-grained interest from a user regarding a particular item and corresponding timestamps when an occurrence of event takes place. The proposed approach is more flexible to capture the dynamic characteristic of event sequences by using the temporal point process to model event data and timely update its intensity function by RNNs. Furthermore, to improve the interpretability of the model, the attention mechanism is introduced to emphasize both intra-personal and inter-personal behavior influence over time. Experiments on real datasets demonstrate that our model outperforms the state-of-the-art methods in fine-grained user interest prediction.
The <i>kit</i>-ligand (steel factor) and its receptor <i>c-kit/W:</i> pleiotropic roles in gametogenesis and melanogenesis (1993)

The c-kit receptor tyrosine kinase belongs to the PDGF/CSF-1/c-kit receptor subfamily. The kit-ligand, KL, also called steel factor, is synthesized from two alternatively spliced mRNAs as transmembrane proteins that can either be proteolytically cleaved to produce soluble forms of KL or can function as cell-associated molecules. The c-kit receptor kinase and KL are encoded at the white spotting (W) and steel (Sl) loci of the mouse, respectively. Mutations at both the W and the Sl locus cause deficiencies in gametogenesis, melanogenesis and hematopoiesis. The c-kit receptor is expressed in the cellular targets of W and Sl mutations, while KL is expressed in their microenvironment. In melanogenesis, c-kit is expressed in melanoblasts from the time they leave the neural crest and expression continues during embryonic development and in the melanocytes of postnatal animals. In gametogenesis c-kit is expressed in primordial germ cells, in spermatogonia, and in primordial and growing oocytes, implying a role at three distinct stages of gametogenesis. Many mutant alleles are known at W and Sl loci and their phenotypes vary in the degree of severity in the different cellular targets of the mutations. While many W and Sl alleles severely affect primordial germ cells (PGC), several mild Sl alleles have weak effects on PGCs and exhibit differential male or female sterility. Steel Panda (Sl(pan)) is a KL expression mutation in which KL RNA transcript levels are reduced in most tissues analyzed. In female Sl(pan)/Sl(pan) mice, ovarian follicle development is arrested at the one layered cuboidal stage as a result of reduced KL expression in follicle cells, indicating a role for c-kit in oocyte growth. Wsh is a c-kit expression mutation, which affects mast cells and melanogenesis. While the mast cell defect results from lack of c-kit expression, the pigmentation deficiency appears to stem from ectopic c-kit receptor expression in the somitic dermatome at the time of migration of melanoblasts from the neural crest to the periphery. It is proposed that the ectopic c-kit expression in Wsh mice affects early melanogenesis in a dominant fashion. The "sash" or white belt of Wsh/+ animals and some other mutant mice is explained by the varying density of melanoblasts along the body axis of wild-type embryos.
S-band all-Raman amplifiers for 40 /spl times/ 10 Gb/s transmission over 6 /spl times/ 100 km of non-zero dispersion fiber (2001)

We present S-band Raman amplifiers that compensate both dispersion and span loss using distributed and discrete amplification over 1488/1518 nm. We transmitted 40 /spl times/ 10 Gb/s over 6 /spl times/ 100 km of a prototype TrueWave/sup AE/ fiber.
Novel N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]pyrid-2(1H)-ones with diversified 5-HT1A receptor activity. (2003)

Novel omega-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl derivatives 1-6 containing 4-, 5- and/or 6-arylsubstituted pyrid-2(1H)-one moiety were synthesized. All the new compounds were examined in vitro to assess their 5-HT1A and 5-HT2A receptor affinities. Compounds 3 and 4 with a 5- or a 6-phenylsubstituted pyridone ring demonstrated high 5-HT1A receptor affinity (Ki = 17 and 38 nM, respectively) and were tested in behavioral functional models. Derivative 3 can be regarded as a weak 5-HT1A postsynaptic antagonist, whereas 4 showed features of a weak partial agonist of 5-HT1A receptors (an agonist of pre- and an antagonist of postsynaptic ones). Binding affinities and in vivo results were discussed in comparison with those for the previously described tetramethylene analogs. The obtained results showed that the shortening of the aliphatic chain to two methylene groups exposed the intrinsic activity of the ligand 4 at 5-HT1A receptor sites.
Automatic Recognition of Diverse 3-D Objects and Analysis of Large Urban Scenes Using Ground and Aerial LIDAR Sensors (2010)

We describe a learning-based 3D object recognition pipeline developed under the DARPA URGENT program for analyzing a large LIDAR dataset collected by both airborne and ground platforms for an extended urban area. Our approach utilizes a novel strip-based cueing approach that incorporates the properties and context of urban objects. Strip-based cueing segments potential objects and assigns them to appropriate classification stages. Our learning-based recognition pipeline successfully recognized 17 3D object classes in LIDAR data collected in and over Ottawa, Canada with high efficiency and average accuracy of 70%.
Modeling of NBTI-Induced PMOS Degradation under Arbitrary Dynamic Temperature Variation (2008)

Negative bias temperature instability (NBTI) is one of the primary limiters of reliability lifetime in nano-scale integrated circuits. NBTI manifests itself in a gradual increase in the magnitude of PMOS threshold voltage, resulting in the degradation of circuit performance over time. NBTI is highly sensitive to operating temperature, making the amount of degradation strongly dependent on the thermal history of the chip. In order to accurately predict the amount of threshold voltage increase, the precise temperature profile must be utilized. The existing models are based on the simplified analysis which assumes that the temperature takes up to two possible fixed values over time. These models are inaccurate when predicting the impact of continuously-changing temperature that spans a large range. Our experiments show that proposed model accounting for temperature variation provides a significantly tighter bound for the simulation than that from the model that ignores the temperature variation and assumes a constant (worst-case) temperature. In our experiment, the amount of degradation predicted by the proposed dynamic temperature model is on average 46% less conservative compared to the model based on the worst-case temperature.
Temporal patterns of cytokine and apoptosis‐related gene expression in spinal cords of the G93A‐SOD1 mouse model of amyotrophic lateral sclerosis (2002)

Familial amyotrophic lateral sclerosis (FALS) is often caused by gain-of-function mutations in Cu,Zn-superoxide dismutase (SOD1). Multiprobe ribonuclease protection assays (RPAs) were used to investigate expression of 36 different cytokines and apoptosis-related genes in spinal cords of mice that ubiquitously express human SOD1 bearing a glycine (r) alanine substitution at residue 93 (G93A-SOD1). Mice were studied at late presymptomatic stage (80 days), and at 120 days when the animals experience severe hindlimb paralysis and accumulation of oxidatively modified proteins. Spinal cord tissue from G93A-SOD1 mice expressed a selective subset of macrophage-typical cytokines (monokines) including interleukin (IL)1alpha, IL1beta and IL1RA at 80 days increasing by 120 days. Contrastingly, T-cell derived cytokines (lymphokines) including IL2, IL3 and IL4 were detected at low levels in non-transgenic mice but these were not elevated in G93A-SOD1 mice even at 120 days. Apoptosis-related genes were generally unaffected at 80 days but multiple caspases and death receptor components were up-regulated at 120 days; the only exceptions being FADD and the tumor necrosis factor (TNF)alpha receptor p55 which was up-regulated at 80 days and increased further at 120 days. These data indicate that in the G93A-SOD1 mouse: (i) cytokine expression changes precede bulk protein oxidation and apoptosis gene expression; (ii) lymphocyte contributions to cytokine expression in FALS are likely minor; and (iii) TNFalpha and its receptors may link inflammation to apoptosis in ALS.
Leadership and Quality of Working Life in Home Health Care (1994)

Home health care has undergone startling changes in the past decade and, in the process, become a strategically important ingredient of health care delivery. However, the question remains whether home health care organizations can deliver the benefits anticipated for integrated care delivery systems. The answer to this question depends to a great extent on whether home health care organizations build vibrant, visionary leadership capable of transforming organizations and motivating staff to deliver high quality and low cost services. This paper examines a case study of transformational leadership as it relates to the quality of working life for nurses, homemakers, and staff. The findings indicate that leader behaviour is strongly associated with homemakers', and to a lesser extent staff members', job satisfaction, job involvement, and propensity to remain with the organization. These job attitudes have been shown to be related to higher job performance. The implications for leadership in home health agencies are discussed.
Ethanol: Modifications of Acute Intoxication by Divalent Cations (1978)

Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.
SCHLECHTER, R., Die Orchideen/hrsg. von F. G. BRIEGER; P. MAATSCH; G. SENGHAS, 3. völlig neubearb. Aufl. Bd. I, 16–18. Lfg. S. 945–1128. Verlag Paul Parey, Berlin, Hamburg, 1983, 1985 (1992)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Development and Cell Biology of the Blood-Brain Barrier (2019)

The vertebrate vasculature displays high organotypic specialization, with the structure and function of blood vessels catering to the specific needs of each tissue. A unique feature of the central nervous system (CNS) vasculature is the blood-brain barrier (BBB). The BBB regulates substance influx and efflux to maintain a homeostatic environment for proper brain function. Here, we review the development and cell biology of the BBB, focusing on the cellular and molecular regulation of barrier formation and the maintenance of the BBB through adulthood. We summarize unique features of CNS endothelial cells and highlight recent progress in and general principles of barrier regulation. Finally, we illustrate why a mechanistic understanding of the development and maintenance of the BBB could provide novel therapeutic opportunities for CNS drug delivery.
Single-electron memory (1993)

A single-electron memory cell, in which one bit of information is represented by +n and −n electron number states, is described. An experimental memory circuit for n ≃100 was fabricated and the basic operation was confirmed at a temperature of 30 mK. This structure can be modified to operate with n = 1.
Binding energy of parallel carbon nanotubes (2003)

We study the interaction between two separate carbon nanotubes that bond together by examing their geometry in transmission electron microscopy (TEM). The TEM image, in conjunction with a continuum mechanics model interpretation, provides an estimate of 0.36 nN binding energy between the two parallel carbon nanotubes. This result agrees well with the calculated binding energy using an atomistic model.
Geometric Manipulation of Trapped Ions for Quantum Computation (2001)

We propose an experimentally feasible scheme to achieve quantum computation based solely on geometric manipulations of a quantum system. The desired geometric operations are obtained by driving the quantum system to undergo appropriate adiabatic cyclic evolutions. Our implementation of the all-geometric quantum computation is based on laser manipulation of a set of trapped ions. An all-geometric approach, apart from its fundamental interest, offers a possible method for robust quantum computation.
A novel beamforming method for wireless ultrasound smart probe (2014)

Recently, in the field of medical ultrasound systems, the wireless smart probe is attracting attention mainly due to its benefits such as improved mobility, ease of use, and effective infection control. This probe has a constraint that all or part of the system beamformer should be integrated inside the probe handle to reduce the data transmission rate of the echo signals that should be transmitted from the probe to the main system. In this case, we should minimize the space of the integrated beamformer, as well as the power dissipation of the hardware in order not to violate the safety regulation, degrade the performance, or make the user uncomfortable due to the generated heat, while maintaining its proper performance. In this paper, we propose a novel beamforming method for wireless smart probe which combines sub-aperture beamforming with phase rotation, digital beamforming, and synthetic aperture sequential beamforming altogether in order to design a probe that meets these constraints effectively and is affordably implementable. The proposed method is verified by the Field II simulation, and the results show that the overall performance of the proposed method is comparable to that of the conventional delay-and-sum beamformer.
Can the import of mRNA into chloroplasts be mediated by a secondary structure of a small non-coding RNA? (2010)

The import of diverse nucleus-encoded proteins into chloroplasts is crucial for plant life. Although this crosstalk is mainly dependent on specific transit peptides, it has been recently reported that a non protein-coding RNA (ncRNA) based on a viroid-derived sequence (vdRNA) and acting as a 5´UTR-end mediates the functional import of GFP-mRNA into chloroplasts. This observation unearths a novel plant cell signaling pathway able to control the accumulation of the nuclear-encoded proteins in this organelle. The mechanisms regulating this chloroplast-specific localization remain yet unclear. To unravel the functional nature of this chloroplastic signal, here we dissect the 5´UTR-end responsible for the chloroplast targeting. A confocal microcopy analysis in Nicotiana benthamiana leaves of the transcripts expression carrying partial deletions of the 5`UTR-end indicate that an internal 110 nucleotides-length fragment is sufficient to mediate the traffic of functional GFP-mRNA into chloroplasts. However, the capability of this motif to act as a chloroplastic localization signal was enhanced when fused to either the 5` or the 3`region of the vd-5´UTR sequence. These findings suggest that the chloroplast-specific RNA targeting is dependent on a structural motif rather than on the RNA sequence.
Association of Quinone-Induced Platelet Anti-Aggregation with Cytotoxicity (2001)

Various anti-platelet drugs, including quinones, are being investigated as potential treatments for cardiovascular disease because of their ability to prevent excessive platelet aggregation. In the present investigation 3 naphthoquinones (2,3-dimethoxy-1,4-naphthoquinone [DMNQ], menadione, and 1,4-naphthoquinone [4-NQ]) were compared for their abilities to inhibit platelet aggregation, deplete glutathione (GSH) and protein thiols, and cause cytotoxicity. Platelet-rich plasma, isolated from Sprague-Dawley rats, was used for all experiments. The relative potency of the 3 quinones to inhibit platelet aggregation, deplete intracellular GSH and protein thiols, and cause cytotoxicity was 1,4-NQ > menadione >> DMNQ. Experiments using 2 thiol-modifying agents, dithiothreitol (DTT) and 1-chloro-2,4-dintrobenzene (CDNB), confirmed the key roles for GSH in quinone-induced platelet anti-aggregation and for protein thiols in quinone-induced cytotoxicity. Furthermore, the anti-aggregative effects of a group of 12 additional quinone derivatives were positively correlated with their ability to cause platelet cytotoxicity. Quinones that had a weak anti-aggregative effect did not induce cytotoxicity (measured as LDH leakage), whereas quinones that had a potent anti-aggregative effect resulted in significant LDH leakage (84-96%). In one instance, however, p-chloranil demonstrated a potent anti-aggregative effect, but did not induce significant LDH leakage. This can be explained by the inability of p-chloranil to deplete protein thiols, even though intracellular GSH levels decreased rapidly. These results suggest that quinones that deplete GSH in platelets demonstrate a marked anti-aggregative effect. If this anti-aggregative effect is subsequently followed by depletion of protein thiols, cytotoxicity results.
Method for the detection of tissue metabolite (H217O) in brain by proton magnetic resonance imaging (1989)

ARAI, TOSHIYUKI MD; GUPTE, PRADEEP M. MSBME; LASKER, SIGMUND E. PHD; DEL GUERCIO, LOUIS R. M. MD; MORI, KENJIRO MD Author Information
Epitope Mapping of the Outer Membrane Protein P5-Homologous Fimbrin Adhesin of Nontypeable <i>Haemophilus influenzae</i> (2000)

To identify potential immunodominant and/or adhesin binding domains of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae (NTHI), three sets of synthetic peptides were synthesized and assayed in an adherence inhibition assay, by Western blotting, and in a biomolecular interaction analysis (BIA) system. The first series of 34 8- to 10-mer peptides represented the entire mature protein sequentially. The second set of four peptides (each 19 to 28 residues) represented the four predicted major surface-exposed regions (or loops) of this adhesin. The third series of seven peptides (each 27 to 34 residues) were specifically designed to map the third surface-exposed region. Data obtained by BIA indicated limited reactivity of a panel of high-titered immune chinchilla sera to the 8- to 10-mer peptides representing the mature protein, likely because these linear peptides did not represent continuous epitopes. However, several of these short peptides did inhibit adherence of multiple NTHI strains to a human respiratory epithelial cell. Overall, greatest relative reactivity in both BIA and adherence inhibition assays was demonstrated against, or shown by, peptides mapping to the third and fourth predicted surface-exposed regions of this adhesin, thereby indicating the presence of immunodominant and adhesin binding domains at these sites. Middle ear fluids sequentially recovered from a chinchilla with an ongoing NTHI-induced otitis media (OM) as well as sera from children with OM due to NTHI also reacted exclusively with peptides representing the third and fourth surface-exposed regions of the P5-fimbrin adhesin, indicating a similarity in immune recognition of this bacterial protein by these two hosts. Collectively, these data together with the previously demonstrated protective efficacy of immunogens derived from this adhesin in chinchilla models support the continued development of P5-fimbrin based vaccine components.
Intuitive virtual grasping for non haptic environments (2002)

This paper presents an approach for grasping virtual objects in virtual environments with a data glove. Our focus lies on developing new methods that allow sensible realistic grasping gestures which correspond to human grasping behavior. To meet the demands of industrial applications, users must be able to grasp an object in an intuitive way with one or two hands and, beyond that, manipulate grasped objects between their fingers. To avoid the use of expensive force or touch feedback hardware, but also to ensure a safe grip on virtual objects, several forms of visual feedback are provided. First, we describe the basic algorithm for grasping with one or two hands and finally, we present a method to precisely manipulate the grasped objects between the virtual fingers.
The isolation and characterisation of human atrial natriuretic factor produced as a fusion protein in <i>Escherichia coli</i> (1988)

Human atrial natriuretic factor [ANF(1–28)] has been isolated from a fusion protein produced in Escherichia coli. ANF(1–28) was linked to a naturally occurring E. coli protein, chloramphenicol acetyltransferase, via unique cleavage sequences susceptible to either human thrombin digestion, or the chemical action of 2‐(2‐nitrophenylsulphenyl)‐3‐methyl‐3′‐bromoindolenine (BNPS‐skatole). The linker sequences were Gly‐Val‐Arg‐Gly‐Pro‐Arg and Trp respectively. The liberated ANF was purified by reversed‐phase HPLC. Optimised cleavage conditions released 5–10% (by mass) of the maximal yield of ANF(1–28) from the fusion protein with the thrombin‐susceptible linker, whilst a 2–5% (by mass) yield was observed from the fusion protein with the tryptophan linker after BNPS‐skatole treatment. The purified cleavage products were biologically active and shown to comprise intact ANF(1–28). Fast‐atom‐bombardment mass spectrometry confirmed [MH] 4 of 3079 m/z , consistent with ANF(1–28).