gebhart/patrepeval huggingface dataset:
CNS INDUCED NEUROGENIC CYSTITIS IS ASSOCIATED WITH BLADDER MAST CELL DEGRANULATION IN THE RAT (2000)

To determine if bladder mast cell degranulation is involved in the genesis of neurogenic cystitis induced by pseudorabies virus (PRV) invasion of the central nervous system (CNS).Rats received a total of 4 x 106 plaque forming units (pfu) of PRV-Bartha in the abductor caudalis dorsalis (ACD) muscle. Granulated bladder mast cells per mm2 of bladder tissue and urine histamine content were monitored as the cystitis developed over the next few days. In a subgroup of rats, intravesical resiniferatoxin was used to remove capsaicin-sensitive sensory bladder afferents, while another subgroup was pretreated with a mast cell degranulator.PRV injection into the ACD muscle leads to neurogenic cystitis. Histamine levels were elevated in the urine of virus injected rats before any behavioral or microscopical signs of cystitis were present. When the cystitis became clinically manifest, urine histamine returned to control levels, and the number of granulated mast cells dropped significantly. Rats in which capsaicin-sensitive afferents had been removed did not show any signs of cystitis, or increase in urine histamine, or change in the number of granulated mast cells. Pretreatment of animals with a mast cell degranulator completely prevented the appearance of cystitis without altering the CNS disease.These results provide further evidence that mast cells are involved in neurogenic cystitis induced by changes in CNS activity.
Trainable Visual Models for Object Class Recognition. (2004)

Recognizing object classes, such as cars, planes or elephants, in an image or a video remains one of the most challenging problems in Computer Vision. However, recently a number of successes have been achieved by using ideas and algorithms from statistical learning theory, where visual models are trained using positive and negative examples of the class.
A Combination of Tandem Amine-Exchange/Heterocyclization and Biaryl Coupling Reactions for the Straightforward Preparation of Phenanthro[9,10-<i>d</i>]pyrazoles (2000)

The tandem amine-exchange/heterocyclization of enaminoketones is successfully applied to the regioselective preparation of a series of new 4,5-diarylpyrazoles by reaction of phenylhydrazine and several 3-N,N-(dimethylamino)-1,2-diarylpropenones. The comparison of a vast array of biaryl coupling procedures provides general, complementary approaches to new phenanthro[9,10-d]pyrazoles. The most efficient procedures for this final step in the construction of the tetracyclic system are based on a Stille-type tandem stannylation-biaryl coupling of o,o'-dihalogenated diarylpyrazoles and an hypervalent iodine-mediated nonphenolic oxidative coupling of nonhalogenated precursors.
Interleukin 1α and tissue-lytic matrix metalloproteinase-1 are elevated in ectopic endometrium of patients with endometriosis (2005)

The increased expression of both matrix-degrading MMP-1 and its major stimulatory cytokine IL-1alpha in endometriotic lesions and the selective co-expression in the stroma of endometriotic foci clearly suggests their involvement in the pathogenic mechanisms leading to local invasion and tissue destruction.
Generating Voltmeter for Pressure-Insulated High Voltage Sources (1940)

A description is given of a generating voltmeter suitable for a voltage source insulated by compressed gas. The calibration is linear and the design simple in that neither amplification nor mechanical commutation is required. The paper discusses the principle of operation, the construction, calibration, and sensitivity, and tests indicating that the influence of corona on the voltage readings is negligible.
Suppression of laser spiking by intracavity second harmonic generation (1991)

Laser spiking in a long pulse Nd:YAG laser has been substantially suppressed by intracavity second harmonic generation with very little loss of laser pulse energy.
Programs in industrial countries to promote foreign direct investment in developing countries (1992)

For many years industrial countries have encouraged domestic firms to make direct investments in developing countries. These direct promotion programs, some of which have existed for several decades, provide the focus of this paper. However, support by industrial country governments has sometimes been ambiguous, many governments have faced serious opposition from domestic interest groups. Many developing countries also have been ambivalent about encouraging inflows of foreign direct investment. These attitudes are now changing on both sides. In this changing environment, this paper surveys the existing bilateral programs of fourteen member countries of the Organization for Economic Cooperation and Development (OECD) and the programs of several multilateral institutions. Chapter 2 gives an overview of the organizations involved in investment promotion, while Chapter 3 outlines the trends of several of the most important bilateral and multilateral investment promotion programs. The underlying principles and practices of both bilateral and multilateral programs are evaluated in Chapter 4 in light of the changing environment, and also of what is now known about effective investment promotion tecniques. Changes in both content and organization of present programs would improve their effectiveness; some of these changes are outlined in Chapter 5.
A key risk indicator approach to central statistical monitoring in multicentre clinical trials: method development in the context of an ongoing large-scale randomized trial (2011)

Background Monitoring in randomized trials is recommended as part of International Conference on Harmonisation Good Clinical Practice standards. On-site monitoring in multicentre trials is common but is costly and can be inefficient. Central statistical monitoring can be used to detect unusual data patterns, identify intentional or unintentional trial misconduct, and to prioritise on-site visits and additional training. Motivated by an ongoing international multicentre clinical trial of over 25,000 randomized participants with electronic data capture, we developed key risk indicator (KRI) methods for central statistical monitoring in multicentre trials.
Programmed neuronal death in insect development (1992)

Programmed death in the developing nervous system of insects serves to remove obsolete neurons, generate segmental specializations and sexual dimorphism, as well as adjust neuronal number. This diversity is also reflected in the mechanisms which control the death of these neurons. In general, but not without exception, these deaths occur independent of target fate, while endocrine cues, segmental identity, and neural signalling often play critical roles. In addition, the programmed death of at least some neurons can be delayed by behavioral feedback. The study of neuronal death in Drosophila and the cloning of an ecdysteroid receptor bring the promise of understanding the genetic factors and molecular events that regulate this phenomenon.
Real-time Scalable Dense Surfel Mapping (2019)

In this paper, we propose a novel dense surfel mapping system that scales well in different environments with only CPU computation. Using a sparse SLAM system to estimate camera poses, the proposed mapping system can fuse intensity images and depth images into a globally consistent model. The system is carefully designed so that it can build from room-scale environments to urban-scale environments using depth images from RGB-D cameras, stereo cameras or even a monocular camera. First, superpixels extracted from both intensity and depth images are used to model surfels in the system. superpixel-based surfels make our method both runtime efficient and memory efficient. Second, surfels are further organized according to the pose graph of the SLAM system to achieve O(1) fusion time regardless of the scale of reconstructed models. Third, a fast map deformation using the optimized pose graph enables the map to achieve global consistency in real-time. The proposed surfel mapping system is compared with other state-of-the-art methods on synthetic datasets. The performances of urban-scale and room-scale reconstruction are demonstrated using the KITTI dataset [1] and autonomous aggressive flights, respectively. The code is available for the benefit of the community.
Formation of repressor-inducer-operator ternary complex: negative cooperativity of d-camphor binding to CamR (2011)

A repressor composed of homodimeric subunits, as is often found in bacteria, possesses two effector-binding sites per molecule, enabling sophisticated regulation by the cooperative binding of two effector molecules. Positive cooperativity generates a narrower region of effector concentration for switching, but little is known about the role of negative cooperativity. d-camphor, an inducer for Pseudomonas putida cytochrome P450cam hydroxylase operon (camDCAB), binds to the homodimeric cam repressor (CamR). Here, we report solid evidence that the complex of CamR and an operator DNA is not dissociated by the first binding of d-camphor but, at a higher concentration, is dissociated by the second binding. d-camphor thus binds to the CamR in two steps with negative cooperativity, yielding two distinct dissociation constants of K(d1 ) =( ) 0.064 ± 0.030 and K(d2 ) =( ) 14 ± 0.3 μm, as well as the Hill coefficient of 0.56 ± 0.05 (<1). The first binding guarantees the high specificity of the inducer by the high affinity, although the second binding turns on the gene expression at a 200-fold higher concentration, a more suitable switching point for the catabolism of d-camphor.
Charge configurations in oncogene products and transforming proteins. (1990)

Statistically significant charge clusters are of infrequent occurrence in all kinds of proteins. In the six standard classes of proto-oncogene products, all of the nuclear class contain a significant charge cluster and several, but not all, of the transmembrane class do, whereas significant charge clusters or patterns are not found in protooncogenes of primarily cytoplasmic location, nor in membrane-bound (src-like) proto-oncogenes, nor in those of the ras family. Among nuclear oncogene families, such as myc, jun, fos, myb, or ets-related, and among homologous proteins across species, the significant charge clusters are part of the most conserved region. These gene families generally have similar charge distributions embodying a significant charge cluster, not of an invariant sign, preceded by a substantial uncharged stretch of predominantly polar residues. The nuclear transforming proteins p53 and p68 also contain significant charge clusters together with long uncharged segments, suggestive of a modular structure of these proteins. The transmembrane oncogene c-mas contains a mixed charge cluster and c-fms displays an unusual (0, +)7 pattern, in both cases positioned within their intracellular activating domain. Distinctive charge configurations for excreted proto-oncogenes are of a mixed character. Possible functions, mechanisms, and associated experimental procedures for studying proteins with anomalous charge distributions are discussed.
Peptides: A Package for Data Mining of Antimicrobial Peptides (2015)

Antimicrobial peptides (AMP) are a promising source of antibiotics with a broad spectrum activity against bacteria and low incidence of developing resistance. The mechanism by which an AMP executes its function depends on a set of computable physicochemical properties from the amino acid sequence. The Peptides package was designed to allow the quick and easy computation of ten structural characteristics own of the antimicrobial peptides, with the aim of generating data to increase the accuracy in classification and design of new amino acid sequences. Moreover, the options to read and plot XVG output files from GROMACS molecular dynamics package are included.
HishiMochi (2000)

We propose a novel browser, HishiMochi, for searching and browsing hierarchically clustered documents. HishiMochi visualizes a hierarchy of clusters and documents as nested rectangles with multi-focus distortion views and animation. It provides suitable views for various search phases, by dynamically changing the DOI (Degree of Interest) function. Using HishiMochi, the user can easily search multiple target documents scattered in the hierarchy, and seamlessly browse their contents in a few operations.
Effect of pH and lactic or acetic acid on ethanol productivity by Saccharomyces cerevisiae in corn mash (2006)

The effects of lactic and acetic acids on ethanol production by Saccharomyces cerevisiae in corn mash, as influenced by pH and dissolved solids concentration, were examined. The lactic and acetic acid concentrations utilized were 0, 0.5, 1.0, 2.0, 3.0 and 4.0% w/v, and 0, 0.1, 0.2, 0.4, 0.8 and 1.6% w/v, respectively. Corn mashes (20, 25 and 30% dry solids) were adjusted to the following pH levels after lactic or acetic acid addition: 4.0, 4.5, 5.0 or 5.5 prior to yeast inoculation. Lactic acid did not completely inhibit ethanol production by the yeast. However, lactic acid at 4% w/v decreased (P<0.05) final ethanol concentration in all mashes at all pH levels. In 30% solids mash set at pH < or =5, lactic acid at 3% w/v reduced (P<0.05) ethanol production. In contrast, inhibition by acetic acid increased as the concentration of solids in the mash increased and the pH of the medium declined. Ethanol production was completely inhibited in all mashes set at pH 4 in the presence of acetic acid at concentrations > or =0.8% w/v. In 30% solids mash set at pH 4, final ethanol levels decreased (P<0.01) with only 0.1% w/v acetic acid. These results suggest that the inhibitory effects of lactic acid and acetic acid on ethanol production in corn mash fermentation when set at a pH of 5.0-5.5 are not as great as that reported thus far using laboratory media.
Degradation of Corticosteroids. V. Preparation and Certain Reactions of 11-Oxygenated-3,5-seco-4-nor-5β-hydroxy-3-oic Acid 3,5-Lactones<sup>1a,b,2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDegradation of Corticosteroids. V. Preparation and Certain Reactions of 11-Oxygenated-3,5-seco-4-nor-5β-hydroxy-3-oic Acid 3,5-Lactones1a,b,2ELIAHU CASPI, WALTER SCHMID, and (Mrs.) BADAR TAQUI KHANCite this: J. Org. Chem. 1961, 26, 10, 3898–3903Publication Date (Print):October 1, 1961Publication History Published online1 May 2002Published inissue 1 October 1961https://pubs.acs.org/doi/10.1021/jo01068a065https://doi.org/10.1021/jo01068a065research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Substrate specificity of the insulin receptor tyrosine kinase domain (1993)

Conference Article| August 01 1993 Substrate specificity of the insulin receptor tyrosine kinase domain Noeleen E. Keane; Noeleen E. Keane 1School of Biochemistry, University of Birmingham, Birmingham B15 2TT U.K. Search for other works by this author on: This Site PubMed Google Scholar Barry A. Levine; Barry A. Levine 1School of Biochemistry, University of Birmingham, Birmingham B15 2TT U.K. Search for other works by this author on: This Site PubMed Google Scholar Philip Quirk; Philip Quirk 1School of Biochemistry, University of Birmingham, Birmingham B15 2TT U.K. Search for other works by this author on: This Site PubMed Google Scholar Bernard Calas; Bernard Calas 2CRNS, Montpellier, France Search for other works by this author on: This Site PubMed Google Scholar Alain Chavanieu; Alain Chavanieu 2CRNS, Montpellier, France Search for other works by this author on: This Site PubMed Google Scholar Florin Grigorescu; Florin Grigorescu 2CRNS, Montpellier, France Search for other works by this author on: This Site PubMed Google Scholar Leland Ellis Leland Ellis 3Institute of Biosciences and Technology, Texas A. & M. University, Houston, Texas, USA Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (3): 266S. https://doi.org/10.1042/bst021266s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Noeleen E. Keane, Barry A. Levine, Philip Quirk, Bernard Calas, Alain Chavanieu, Florin Grigorescu, Leland Ellis; Substrate specificity of the insulin receptor tyrosine kinase domain. Biochem Soc Trans 1 August 1993; 21 (3): 266S. doi: https://doi.org/10.1042/bst021266s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Resonantly Coupled Accelerating Structures for High-Current Proton Linacs (1965)

The results of model studies and an equivalent circuit analysis of the operation of a chain of cavities in the /g=P//2 mode is given. Various /g=p//2 mode structures are described and the performance of models of these structures is discussed. Results of numerical solutions to an equivalent circuit applicable to the problem are also given, which include frequency error tolerances and coupling tolerances, for typical cases of interest. Multiple drive of a long resonator chain is also discussed.
Passive Pitch Control of Small Horizontal Axis Wind Turbines (2004)

Abstract Small wind turbines utilize various mechanisms to regulate power. One concept is to pitch the blades to feather as wind speeds increase. This paper presents the development and application of an analysis tool to a conceptual passive pitch control of a 1 kW hori-zontal axis wind turbine that is based upon the rotor blades and generator characteristics of the Southwest Windpower’s Whisper H40 wind turbine. The current analysis and concept machine is constrained to only two-degrees of freedom (rotor spin about the main shaft and pitch-link motion about its pivot point) at 0 o yaw error with respect to the main wind direction. The current analysis tool is the starting point of a more complete methodology that will include addi-tional degrees of freedom. A simple strip theory model provides the aerodynamics as a function of the relative wind vector’s magnitude and local angle of attack. The second order dynamics equations of mo-tion for the two-degree of freedom system were solved using forth-order Runge-Kutta time integra-tion tools in MATLAB. Calculations for static and turbulent winds including IEC standard extreme wind conditions have been performed for the concept ma-chine. In summary, this paper presents the develop-ment and application of a new design/analysis tool specifically implemented for small wind turbines.
<i>c</i>‐<i>fos</i> and estrogen receptor gene expression pattern in the rat uterine epithelium during the estrous cycle (2003)

Different studies in ovariectomized estrogen treated animals support the idea that c-fos plays a role in the proliferation of uterine epithelial cells. However, these studies invite us to reassess the role played by c-fos in epithelial cell types of the endometrium during the estrous cycle. The present study was undertaken to determine the c-fos and estrogen receptor (ER) gene expression pattern in the rat uterine epithelium during the estrous cycle in which natural and cyclic changes of steroid hormones occur, and correlate these changes with the proliferation status of this cellular types. Proliferation was assessed during the estrous cycle using bromodeoxyuridine incorporation to DNA. ERalpha and beta proteins were assessed by immunohistochemistry. The regulation of c-fos gene expression in the uterus of intact animals during the estrous cycle was evaluated using both in situ hybridization and immunohistochemistry. Estradiol (E(2)) and progesterone (P(4)) plasma levels were assessed by radioimmunoassay. The results indicated that luminal (LE) and glandular epithelia (GE) presented maximal proliferation during the metestrus (M) and the diestrus (D) days. However, during the proestrus (P) day only LE presented proliferation, and during the estrus (E) day only the stromal cells proliferated. A marked immunostaining for ERalpha was detected in both LE and GE cells during the early phases of the cycle but diminished on the P and the E day. In contrast, ERbeta was undetectable in both epithelia during all stages of the cycle. The highest c-fos mRNA level was detected in both epithelia on the M day, followed by a significant reduction during the other days of the cycle. The highest protein content was observed on the M and D days, and the minimal value was detected on the E day. The c-Fos protein level in LE was increased during M and D days, presenting a high correlation with the cellular proliferation pattern of this cell type. In conclusion, the overall results indicate that c-Fos protein presented a good correlation with uterine epithelial cell proliferation of LE. In the case of GE, the same tendency was observed, although no significant correlation was found. Both in LE and GE, c-fos mRNA did not strictly correlate with its protein levels. c-fos seems to have a postranscriptional regulation in uterine epithelial cells during the rat's estrous cycle.
Multisensor fusion based tracking of coalescing objects in urban environment for an autonomous vehicle navigation (2008)

This article addresses detection, association and tracking of coalescing objects in urban environment for autonomous navigation using multiple sensors. The stress is put on providing description of surroundings for the task of local navigation and collision avoidance. An Oriented Bounding Box representation is proposed for dynamic obstacles, as well as data association technique suitable for the used representation. Fusion of multiple sensors is used in order to increase the accuracy and the robustness of the tracking system. The sensors configuration consists of two laser range finders and a LIDAR.
Nondestructive Testing for Shallow Defect of Ferromagnetic Objects Based on Magnetic Probe Structure (2018)

The magnetic flux leakage (MFL) technology is one of the most widely used electromagnetic nondestructive testing techniques. To magnetize the detected object near to saturated flux density, the excitation mechanism is heavy and large in the MFL technology. A simple and portable magnetic detector device for shallow defect of ferromagnetic objects based on the magnetic probe structure is designed in this paper. The proposed magnetic detector is very light, cheap, and easy to design and manufacture. The magnetic detector can make the qualitative and quantitative evaluation for shallow defect of ferromagnetic objects. In steel ribbon test, the maximum relative error of quantitative test results is less than 5% by the proposed magnetic detector device. In this paper, the application of the magnetic detection method for wire rope is proposed. By the proposed method, qualitative and positional detection of the wire rope defects can be easily achieved.