gebhart/patrepeval huggingface dataset:
Transgenic expression of human <i>MGMT</i> protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-<i>ras</i> oncogene of mouse colon (1995)

Transgenic mice over-expressing MGMT, which codes for the human protein O6-alkylguanine-DNA alkyltransferase, are protected from methylating agent-induced thymic lymphomas. In this study we evaluated the ability of transgenic overexpression of MGMT in the colon to protect mice from the development of azoxymethane(AOM)-induced aberrant crypt foci (ACF) and mutations in K-ras. Colonic alkyltransferase in MGMT+ transgenic mice was > 5-fold higher than in nontransgenics: 10.5 +/- 1.1 vs 2.2 +/- 1.1 fmol/micrograms DNA, P = < 0.0001. Mice received 20 mg AOM/kg i.p. at 6 weeks or 15 mg AOM/kg at 6 and 7 weeks of age, and 8 wks later colons were examined for ACF. A significant protective effect of MGMT was seen in mice given single dose of 20 mg AOM/kg. The incidence of ACF/colon was lower in MGMT+ mice (2.0 +/- 1.2) than in nontransgenic mice (3.9 +/- 1.8, P = 0.02). G to A mutations in codon 12 of K-ras were detected by PCR-RFLP in ACF and in random samples of normal appearing mucosa. The incidence of ACF with mutant K-ras in MGMT transgenic mice (0.6 +/- 0.7/colon) was significantly reduced compared to nontransgenic mice (2.3 +/- 1.7/colon, P = 0.02). We propose that AOM induces at least two overlapping but not identical premalignant lesions (aberrant crypt foci and K-ras mutations) which can be prevented by over-expression of MGMT. Thus, MGMT may protect colonic mucosa from carcinogenesis involving methylating agents such as AOM.
Generating non-redundant association rules (2000)

Article Free Access Share on Generating non-redundant association rules Author: Mohammed J. Zaki Computer Science Department, Rensselaer Polytechnic Institute, Troy, NY Computer Science Department, Rensselaer Polytechnic Institute, Troy, NYView Profile Authors Info & Claims KDD '00: Proceedings of the sixth ACM SIGKDD international conference on Knowledge discovery and data miningAugust 2000 Pages 34–43https://doi.org/10.1145/347090.347101Published:01 August 2000Publication History 318citation1,591DownloadsMetricsTotal Citations318Total Downloads1,591Last 12 Months59Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity (2002)

All-trans-retinoic acid is a potent inhibitor of cell proliferation and inducer of differentiation. However, the clinical use of all-trans-retinoic acid in the treatment of cancer is significantly hampered by its toxicity and the prompt emergence of resistance, believed to be caused by increased all-trans-retinoic acid metabolism. Inhibitors of all-trans-retinoic acid metabolism may therefore prove valuable in the treatment of cancer. In this study, we characterize R116010 as a new anticancer drug that is a potent inhibitor of all-trans-retinoic acid metabolism. In vitro, R116010 potently inhibits all-trans-retinoic acid metabolism in intact T47D cells with an IC(50)-value of 8.7 nM. In addition, R116010 is a selective inhibitor as indicated by its inhibition profile for several other cytochrome P450-mediated reactions. In T47D cell proliferation assays, R116010 by itself has no effect on cell proliferation. However, in combination with all-trans-retinoic acid, R116010 enhances the all-trans-retinoic acid-mediated antiproliferative activity in a concentration-dependent manner. In vivo, the growth of murine oestrogen-independent TA3-Ha mammary tumours is significantly inhibited by R116010 at doses as low as 0.16 mg kg(-1). In conclusion, R116010 is a highly potent and selective inhibitor of all-trans-retinoic acid metabolism, which is able to enhance the biological activity of all-trans-retinoic acid, thereby exhibiting antitumour activity. R116010 represents a novel and promising anticancer drug with an unique mechanism of action.
Polymerization of monomers containing functional silyl groups. 6. Anionic polymerization of 2-(trialkoxysilyl)-1,3-butadiene (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymerization of monomers containing functional silyl groups. 6. Anionic polymerization of 2-(trialkoxysilyl)-1,3-butadieneKatsuhiko Takenaka, Takashi Hattori, Akira Hirao, and Seiichi NakahamaCite this: Macromolecules 1989, 22, 4, 1563–1567Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April 1989https://pubs.acs.org/doi/10.1021/ma00194a010https://doi.org/10.1021/ma00194a010research-articleACS PublicationsRequest reuse permissionsArticle Views387Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Extraction of uranium from seawater: chemical process and plant design feasibility study (1979)

A major assessment was made of the uranium resources in seawater. Several concepts for moving seawater to recover the uranium were investigated, including pumping the seawater and using natural ocean currents or tides directly. The optimal site chosen was on the southeastern Puerto Rico coast, with the south U.S. Atlantic coast as an alternate. The various processes for extracting uranium from seawater were reviewed, with the adsorption process being the most promising at the present time. Of the possible adsorbents, hydrous titanium oxide was found to have the best properties. A uranium extraction plant was conceptually designed. Of the possible methods for contacting the seawater with the adsorbent, a continuous fluidized bed concept was chosen as most practical for a pumped system. A plant recovering 500 tonnes of U/sub 3/O/sub 8/ per year requires 5900 cubic meters per second of seawater to be pumped through the adsorbent beds for a 70% overall recovery efficiency. Total cost of the plant was estimated to be about $6.2 billion. A computer model for the process was used for parametric sensitivity studies and economic projections. Several design case variations were developed. Other topics addressed were the impact of co-product recovery, environmental considerations, etc.
Comparison of multilevel inverters for static VAr compensation (2002)

Inverter-based static VAr compensators (SVCs) can benefit from the use of a multilevel invertor structure which allows the elimination of the step-up transformer. The inherent high quality of the multistep waveform allows operation without PWM, thus high switching losses are avoided. This paper discusses the issues affecting the application of multilevel invertor structures as reactive power compensators and compares the device MVA and reactive component MVA requirements of two topologies that have been presented in prior literature. The modulation strategy strongly affects the voltage balancing in the DC bus capacitors as well as their ripple current rating and capacitance value.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Kukkia and Vilkas: Kinetic Electronic Garments (2005)

This paper describes our first experiments in developing kinetic electronic garments, within the context of fashion and personal expression. We have integrated the shape memory alloy Nitinol in textile substrates to create Kukkia and Vilkas, two animated dresses that move or change shape over time, using resistive heating and control electronics. We describe fabrication details, including Nitinol shape setting and felting of the textile substrate. We suggest various models for programming the behavior of such an artifact, including animated, reactive, and interactive models.
Implementation of a Cloud-Assisted REST Service Interface for Policy-Based Data Offloading (2014)

The rapid adoption of the Internet and the ubiquitous coverage of cellular/wireless technologies, all concur to the fusion of networks' physical boundaries. At the same time, the proliferation of mobile and wireless devices changes our expectations as users, forcing enterprises to rethink their network and device management (NDM) approaches. A major driver is the changing role of the end-user, who is now empowered by multiple devices, each with multiple interfaces. In this context, we view Network and Device Management (NDM) as the melting pot for network operations (network management) and system administration (host management), all taking place over user-owned and controlled devices. Our work contributes to the convergence of NDM with the analysis, design, and implementation of a resource-oriented cloud-based NDM service. For interoperability, we use YANG data modeling language to compose new modules and JSON notation to encode policies. Using a proof-of-concept policy example, we present a prototype implementation on a Linux smartphone and demonstrate how policies achieve data offloading for the benefit of users and operators.
Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina (1990)

Video-enhanced differential interference contrast optics was used to determine the number and distribution of photoreceptors across the entire retinal surface of 9 eyes obtained from 7 adult rhesus monkeys. We found that the retina of this primate contains an average of 3,100,000 cones (+/- 130,000) and 61,000,000 rods (+/- 7,500,000). Variation among animals in the number of rods and cones cannot be accounted for by differences in sex, age, or retinal surface area, nor is there a correlation between the number of rods and cones (a retina with a high number of rods does not typically have a high number of cones). Cone density peaks at 141,000 cones/mm2 in the foveola and decreases about 100-fold toward the periphery. Rod density in a central annulus around the fovea is 130,000/mm2 and decreases 6-8-fold toward the periphery. In all 9 retinae, we found that an area 4-5 mm dorsal to the fovea had the highest rod density at 184,000 rods/mm2. The functional significance of this area, which we term the dorsal rod peak (DRP), may be related to high sensitivity vision under scotopic conditions. Outside of the DRP, rod density is symmetrical around the major axes of the retina, whereas cone density is elevated in nasal retina. Among animals, both rods and cones display a 2-fold individual difference in receptor density at any given eccentricity. Although rods and cones differ in absolute number, the location and magnitude of their peak densities, and their central to peripheral density gradients, the ratio of the density of rods to cones (15-30:1) is remarkably stable from 3 mm to 15 mm eccentricity. The relative consistency in the proportion of rods and cones in extrafoveal retina may be related to mechanisms of retinal development and functional interactions between scotopic and photopic systems.
Mechanism of Inhibition of HIV-1 Integrase by G-tetrad-forming Oligonucleotides in Vitro (2000)

The G-tetrad-forming oligonucleotides and have been identified as potent inhibitors of human immunodeficiency virus type 1 integrase (HIV-1 IN) activity (Rando, R. F., Ojwang, J., Elbaggari, A., Reyes, G. R., Tinder, R., McGrath, M. S., and Hogan, M. E. (1995) J. Biol. Chem. 270, 1754-1760; Mazumder, A., Neamati, N., Ojwang, J. O., Sunder, S., Rando, R. F., and Pommier, Y. (1996) Biochemistry 35, 13762-13771; Jing, N., and Hogan, M. E. (1998) J. Biol. Chem. 273, 34992-34999). To understand the inhibition of HIV-1 IN activity by the G-quartet inhibitors, we have designed the oligonucleotides and, composed of three and four G-quartets with stem lengths of 19 and 24 A, respectively. The fact that increasing the G-quartet stem length from 15 to 24 A kept inhibition of HIV-1 IN activity unchanged suggests that the binding interaction occurs between a GTGT loop domain of the G-quartet inhibitors and a catalytic site of HIV-1 IN, referred to as a face-to-face interaction. Docking the NMR structure of (Jing and Hogan (1998)) into the x-ray structure of the core domain of HIV-1 IN, HIV-1 IN-(51-209) (Maignan, S., Guilloteau, J.-P. , Qing, Z.-L., Clement-Mella, C., and Mikol, V. (1998) J. Mol. Biol. 282, 359-368), was performed using the GRAMM program. The statistical distributions of hydrogen bonding between HIV-1 IN and were obtained from the analyses of 1000 random docking structures. The docking results show a high probability of interaction between the GTGT loop residues of the G-quartet inhibitors and the catalytic site of HIV-1 IN, in agreement with the experimental observation.
Patterns of coordination in Improvise visualizations (2007)

Visualization systems have evolved into live-design environments in which users explore information by constructing coordinated multiview visualizations rapidly and interactively. Although these systems provide built-in support for well-known coordinations, they do not allow invention of novel coordinations or customization of existing ones. This paper presents a categorization of 29 coordination patterns that have proven to be broadly useful for visual data analysis. By coupling coordination with visual abstraction, it has been possible to realize 27 of these patterns in Improvise, demonstrated here with five example visualizations.
Attenuating the defibrillation dosage decreases postresuscitation myocardial dysfunction in a swine model of pediatric ventricular fibrillation (2008)

Unattenuated adult-dose defibrillation results in a greater frequency of myocardial damage and worse postresuscitation myocardial function than pediatric doses in a swine model of prolonged out-of-hospital pediatric ventricular fibrillation cardiac arrest. These data support the use of pediatric attenuating electrodes with adult biphasic automated external defibrillators to defibrillate children.
Numerical Methods in Economics (1998)

To harness the full power of computer technology, economists need to use a broad range of mathematical techniques. In this book, Kenneth Judd presents techniques from the numerical analysis and applied mathematics literatures and shows how to use them in economic analyses. The book is divided into five parts. Part I provides a general introduction. Part II presents basics from numerical analysis on R^n, including linear equations, iterative methods, optimization, nonlinear equations, approximation methods, numerical integration and differentiation, and Monte Carlo methods. Part III covers methods for dynamic problems, including finite difference methods, projection methods, and numerical dynamic programming. Part IV covers perturbation and asymptotic solution methods. Finally, Part V covers applications to dynamic equilibrium analysis, including solution methods for perfect foresight models and rational expectation models. A web site contains supplementary material including programs and answers to exercises.
How many addressing modes are enough? (1987)

Programs naturally require a variety of memory-addressing modes. It isn't necessary to provide them in hardware, however, if a compiler can synthesize them from a few primitive modes. This not only simplifies the hardware, but also permits the compiler to use its understanding of the program to economize on the modes which it uses. We present some compilation techniques that allow the compiler to deal effectively with a single addressing mode in a target RISC processor. We also give measurements to show the benefits of such techniques, and to support our assertion that a single addressing mode is adequate for a general purpose processor, provided that mode incorporates both a pointer and an offset.
Interaction of human .alpha.-1-proteinase inhibitor with neutrophil myeloperoxidase (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInteraction of human .alpha.-1-proteinase inhibitor with neutrophil myeloperoxidaseN. R. Matheson, P. S. Wong, M. Schuyler, and J. TravisCite this: Biochemistry 1981, 20, 2, 331–336Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/bi00505a016https://doi.org/10.1021/bi00505a016research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Photoreceptor Protection against Constant Light-Induced Damage by Isopropyl Unoprostone, a Prostaglandin F<sub>2α</sub> Metabolite-Related Compound (2001)

Some of the antiglaucoma drugs have shown neuroprotective effects in ischemic retinal damage and optic nerve injury. We studied photoreceptor protection against constant light-induced damage using isopropyl unoprostone, a prostaglandin F(2alpha) metabolite-related compound. Albino Sprague-Dawley rats were administered isopropyl unoprostone solution intravitreally in one eye (the test eye) and vehicle alone in the contralateral eye (the control eye) and were exposed to constant light for 7 days. Histological examinations were performed to evaluate photoreceptor protection by quantifying the outer nuclear layer (ONL) thickness and scoring the rescue of ONL. Seven-day constant light affected photoreceptors and produced a marked disruption of photoreceptor outer segments and inner segments and a decrease in the thickness of the ONL. As compared with control eyes, pretreatment by intravitreal administration of isopropyl unoprostone 2 days prior to constant light exposure provided protection from the light insult, and the effects of rescue were dependent on the dose of the agent (0.6-6.0 microg), the maximum dose protecting about 70% of the photoreceptors. Topical application of the drug had little rescue effect. Aberrant macrophages in light-exposed eyes with unoprostone injection were more numerous than in normal eyes, but the extent did not differ significantly from that of degenerated eyes injected with vehicle only. Isopropyl unoprostone has shown protection of photoreceptors against constant light-induced damage, and it is thus suggested that the agent has neuroprotective activity in vivo.
Predicting Voltage Characteristic of Charging Model for Li-Ion Battery with ANN for Real Time Diagnosis (2018)

An adaptive characteristic of charging for the rechargeable batteries using the artificial neural network (ANN) method is proposed in this study. This model is based on the voltage charging data of a Li-Ion battery. By the voltage characteristic of charging data that have been used as a parameter to describe the actual quantity of energy, which is a key factor in applications. This estimation is an important and challenging task. The upcoming Electric Vehicle (EV) or Hybrid Electric Vehicle (HEV), are becoming the most important technology in transportation, because of the Eco-friendly and its increasing driving autonomy. The battery performance directly influences the total performance and efficiency of the BMS for this kind of vehicles. As already confirmed the importance of the battery state of charge (SOC) prediction and the nonlinear characteristic between the battery SOC and the external variables, the neural network model is proposed in order to investigate further. In this approach, the ANN can predict the characteristic of the charging model from the batteries, with the optimized model it can be simulated within a short time and with a high accuracy. Which is a different type of approach to the difficult task of SOC of the battery.
Integrating design and measurement (2005)

At the 2004 International Instrumentation and Measurement Conference in Italy, a number of us were discussing the growing importance of system-level design and the implications for simulation and measurement technologies. It was puzzling to us that technology continues to increase in complexity, yet the last two decades have seen the design world of simulation and modeling diverge from the world of measurement and testing. Today's systems, whether they are commercial products or scientific experiments, require a convergence of technologies that makes performance measurement and validation not only more critical but also more prone to error. In the discussions a point that came up repeatedly was the value of bringing the design and test communities closer together, and it was suggested that it was timely to highlight this issue. With that in mind, this note aims to stimulate community discussion by first examining some benefits and challenges of integration and then outlining possible directions for collaboration between the simulation and measurement communities.
Analysis of the Transcription Factor WUSCHEL and Its Functional Homologue in <i>Antirrhinum</i> Reveals a Potential Mechanism for Their Roles in Meristem Maintenance (2006)

One of the most significant features of plant development is the way in which it can be elaborated and modulated throughout the life of the plant, an ability that is conferred by meristems. The Arabidopsis thaliana WUSCHEL gene (WUS), which encodes a homeodomain transcription factor, is required to maintain the stem cells in the shoot apical meristem in an undifferentiated state. The mechanism by which WUS prevents the differentiation of stem cells is unknown. We have characterized a meristem maintenance mutant in Antirrhinum majus and shown that it arises from a defect in the WUS orthologue ROSULATA (ROA). Detailed characterization of a semidominant roa allele revealed an essential role for the conserved C-terminal domain. Expression of either ROA or WUS lacking this domain causes a failure of meristem maintenance. The conserved domain mediates an interaction between WUS and two members of a small family of corepressor-like proteins in Arabidopsis. Our results suggest that WUS functions by recruiting transcriptional corepressors to repress target genes that promote differentiation, thereby ensuring stem cell maintenance.