gebhart/patrepeval huggingface dataset:
A simple and practical synthesis of olivetol (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA simple and practical synthesis of olivetolAntonio Focella, Sidney Teitel, and Arnold BrossiCite this: J. Org. Chem. 1977, 42, 21, 3456–3457Publication Date (Print):October 1, 1977Publication History Published online1 May 2002Published inissue 1 October 1977https://pubs.acs.org/doi/10.1021/jo00441a036https://doi.org/10.1021/jo00441a036research-articleACS PublicationsRequest reuse permissionsArticle Views2032Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A comparison of Goldmann and Humphrey automated perimetry in patients with glaucoma. (1987)

Humphrey automated threshold perimetry (Program 30-2) was performed on 42 eyes of 25 patients with glaucoma to determine both the sensitivity and specificity of automated perimetry in detecting glaucomatous visual field defects. Automated perimetry sensitivity was 90.38%, while automated perimetry specificity was 91%. Fifty-two patients and a technician took part in a survey to determine their preference for either test. Patients generally preferred having Goldmann perimetry. The technician favoured Humphrey automated perimetry. Program 30-2 on the automated perimeter took 25% longer to perform than Goldmann perimetry.
Eukaryotic transcription factors (2001)

A comparative study based on four fully sequenced eukaryotic genomes has revealed profound differences in the sets of transcription factors used by plants, fungi and animals.
Monoaural musical hallucinations caused by a thalamocortical auditory radiation infarct: a case report (2014)

We propose that all patients with monoaural musical hallucinations have brain imaging to rule out a central organic cause, especially within the non-dominant hemisphere, regardless of the presence of a hearing impairment.
Antifibrotic and Hemodynamic Effects of the Early and Chronic Administration of Octreotide in Two Models of Liver Fibrosis in Rats (1998)

The aim of this study was to assess the effect of the early and chronic administration of octreotide in the prevention of hepatic fibrosis and portal hypertension (PHT). Two experimental models of liver fibrosis caused by bile duct ligation (BDL) or CCl4 were divided into 4 rat groups: sham, placebo, and octreotide (10 and 100 micrograms/kg twice daily, subcutaneously). Liver fibrosis was assessed by the area of fibrosis (image analysis), liver hydroxyproline and fibronectin mRNA contents, and serum hyaluronate. Systemic and splanchnic hemodynamic changes were also evaluated, including the splenorenal shunt blood flow by the transit-time ultrasound (TTU) technique. In both models, splenorenal shunt blood flow was significantly lower in the octreotide groups than in the placebo group (P <.05), while portal pressure was not significantly decreased. There was a significant decrease in fibrosis by octreotide in the CCl4 model only: area of fibrosis: 13.9% +/- 3.7% vs. 9.8% +/- 2.5% (P <.01), hydroxyproline: 1.8 +/- 0.6 vs. 1.3 +/- 0.4 mg/g wet liver (P <.05), respectively, placebo vs. octreotide 10 micrograms/kg. There was a significant correlation between the area of fibrosis and hydroxyproline liver content (r =.87 in the biliary model and r =.91 in the CCl4 model; P <.0001). The early and chronic administration of octreotide prevents the development of portocollateral blood flow without reducing portal pressure in two models of liver fibrosis and the development of liver fibrosis in the CCl4 model.
Silicones Containing Pendant Biocides for Antifouling Coatings (2004)

The preparation of biocide-incorporated silicone coatings for antifouling/fouling release applications is described. The biocide Triclosan (5-chloro-2-(2, 4-dichlorophenoxy) phenol) was modified with alkenyl moieties and incorporated into a silicone backbone through covalent bonds. The presence of the biocide on the coating surface was expected to deter fouling organisms from attaching to the surface of the coating. Allyl glycidyl ether was used to provide crosslink functionalities. Resins were cured using vinyl-terminated polydimethylsiloxane for hydrosilyl functionality and 1, 3-cyclohexane-bis (methylamine) for epoxy crosslinking functionality. Coatings were characterized by static water contact angle measurements and dynamic mechanical thermal analysis. Synthetic control over the incorporation of crosslink functionalities within the polymer resin allowed tuning of the surface of the coating and of mechanical properties. Resistance to macrofouling was tested by static immersion tests in the Indian River Lagoon at the Florida Institute of Technology from 15 October 2003 to 13 November 2003. Preliminary results showed that the coatings prepared from biocide-incorporated silicones with the appropriate bulk modulus significantly reduced macrofouling.
Cloning of Full-Length cDNA of Teleost Corticotropin-Releasing Hormone Precursor by Improved Inverse PCR (2006)

We designed a new inverse PCR protocol combined with switching mechanism at 5' end of RNA transcript (SMART) technology, and applied it to the cloning of teleost corticotropin-releasing hormone precursor cDNA. Due to the advantages of both techniques, this method can efficiently amplify the complete 5'- and 3'-ends of cDNA in a single reaction, and might prove to be an alternative to the conventional rapid amplification of cDNA ends (RACE) approaches.
Inactivation of Substance P by Tissue extracts (1943)

Summary. The inactivating power of protein tissue extracts was studied on a purified preparation of substance P from horse's intestine. Extracts from the muscular coat of horse's intestine, corresponding to 0.1 g dry tissue pr ml, causes half inactivation of substance P in 5 units per ml in about 20 minutes at pH 6.5 and 38° C. Extracts from basal ganglia of brain from man and horse prepared in the same way have a still stronger inactivating power on substance P. These effects are abolished by boiling the extracts, indicating that the inactivation is of enzymatic nature. The pH‐optimum of this reaction is between pH 6–7. Extract from striated muscle proved to have comparatively feable inactivating action on substance P, whereas blood and extracts from spinal cord were without action at the concentrations studied.
Modes of business governance: European management styles and corporate cultures (1997)

This article examines the role of corporate culture. It highlights the impact that cultural norms and institutional values may play in shaping managerial decision making in German, French, Swedish and British companies. It is argued that corporate culture is crucial to the ability of such organisations to respond to a more integrated, competitive European economy. Rather than assume, as many economics studies have, that businesses are simply ‘black boxes’ which respond to external markets and regulatory forces, this article focuses on the ‘behavioural side’ of business, which has been little touched upon in previous studies of European integration.
High-Yield Uniform Synthesis and Microstructure-Determination of Rice-Shaped Silver Nanocrystals (2009)

High-yield uniform silver nanorices were synthesized by a facile polyol process without the introduction of shape-selected seeds. Nanorices exhibit two plasmon resonance peaks in the visible and near-infrared regions respectively due to their anisotropy. XRD patterns demonstrated the HCP phase coexists with the FCC phase in nanorices. The novel structure of nanorices was characterized by TEM study which shows that the intergrowth of FCC and a small amount of HCP phase, nanoscale FCC (111) twinning structure, and multimodulated structures formed by a complicated stacking sequence along the long axis direction. The correlation between morphology and microstructure is discussed.
Surface Related Multiple Suppression in Dual-sensor Towed Streamer Data (2008)

Conventional surface related multiple prediction for towed streamer configuration is flawed by the sea surface level variation and sea surface reflection coefficient fluctuation. Knowledge of the sea surface and reflection coefficient allows approximate correction of the prediction errors. Based on a novel dual-sensor towed streamer acquisition we propose a multiple prediction approach from the down-going vertical velocity field and up-going pressure field. This approach handles the obliquity factor and sea surface variations implicitly and may reduce bad-weather-related acquisition downtime.
Natural-Based Hydrogels for Tissue Engineering Applications (2020)

In the field of tissue engineering and regenerative medicine, hydrogels are used as biomaterials to support cell attachment and promote tissue regeneration due to their unique biomimetic characteristics. The use of natural-origin materials significantly influenced the origin and progress of the field due to their ability to mimic the native tissues' extracellular matrix and biocompatibility. However, the majority of these natural materials failed to provide satisfactory cues to guide cell differentiation toward the formation of new tissues. In addition, the integration of technological advances, such as 3D printing, microfluidics and nanotechnology, in tissue engineering has obsoleted the first generation of natural-origin hydrogels. During the last decade, a new generation of hydrogels has emerged to meet the specific tissue necessities, to be used with state-of-the-art techniques and to capitalize the intrinsic characteristics of natural-based materials. In this review, we briefly examine important hydrogel crosslinking mechanisms. Then, the latest developments in engineering natural-based hydrogels are investigated and major applications in the field of tissue engineering and regenerative medicine are highlighted. Finally, the current limitations, future challenges and opportunities in this field are discussed to encourage realistic developments for the clinical translation of tissue engineering strategies.
Hierarchical Transformer Network for Utterance-Level Emotion Recognition (2020)

While there have been significant advances in detecting emotions in text, in the field of utterance-level emotion recognition (ULER), there are still many problems to be solved. In this paper, we address some challenges in ULER in dialog systems. (1) The same utterance can deliver different emotions when it is in different contexts. (2) Long-range contextual information is hard to effectively capture. (3) Unlike the traditional text classification problem, for most datasets of this task, they contain inadequate conversations or speech. (4) To better model the emotional interaction between speakers, speaker information is necessary. To address the problems of (1) and (2), we propose a hierarchical transformer framework (apart from the description of other studies, the “transformer” in this paper usually refers to the encoder part of the transformer) with a lower-level transformer to model the word-level input and an upper-level transformer to capture the context of utterance-level embeddings. For problem (3), we use bidirectional encoder representations from transformers (BERT), a pretrained language model, as the lower-level transformer, which is equivalent to introducing external data into the model and solves the problem of data shortage to some extent. For problem (4), we add speaker embeddings to the model for the first time, which enables our model to capture the interaction between speakers. Experiments on three dialog emotion datasets, Friends, EmotionPush, and EmoryNLP, demonstrate that our proposed hierarchical transformer network models obtain competitive results compared with the state-of-the-art methods in terms of the macro-averaged F1-score (macro-F1).
Selective COX-2 Inhibition Improves Endothelial Function in Coronary Artery Disease (2003)

Background— There is an ongoing debate as to whether the gastrointestinal safety of COX-2 inhibition compared with nonsteroidal antiinflammatory drugs (NSAIDs) may come at the cost of increased cardiovascular events. In view of the large number of patients at cardiovascular risk requiring chronic analgesic therapy with COX-2 inhibitors for arthritic and other inflammatory conditions, the effects of selective COX-2 inhibition on clinically useful surrogates for cardiovascular disease, particularly endothelial function, need to be determined. Methods and Results— Fourteen male patients (mean age, 66±3 years) with severe coronary artery disease (average of 2.6 vessels with stenosis >75%) undergoing stable background therapy with aspirin and statins were included. The patients received celecoxib (200 mg BID) or placebo for a duration of 2 weeks in a double-blind, placebo-controlled, crossover fashion. After each treatment period, flow-mediated dilation of the brachial artery, high-sensitivity C-reactive protein, oxidized LDL, and prostaglandins were measured. Celecoxib significantly improved endothelium-dependent vasodilation compared with placebo (3.3±0.4% versus 2.0±0.5%, P =0.026), whereas endothelium-independent vasodilation, as assessed by nitroglycerin, remained unchanged (9.0±1.6% versus 9.5±1.3%, P =0.75). High-sensitivity C-reactive protein was significantly lower after celecoxib (1.3±0.4 mg/L) than after placebo (1.8±0.5 mg/L, P =0.019), as was oxidized LDL (43.6±2.4 versus 47.6±2.6 U/L, P =0.028), whereas prostaglandins did not change. Conclusions— This is the first study to demonstrate that selective COX-2 inhibition improves endothelium-dependent vasodilation and reduces low-grade chronic inflammation and oxidative stress in coronary artery disease. Thus, selective COX-2 inhibition holds the potential to beneficially impact outcome in patients with cardiovascular disease.
Influence of Li content on electrical properties of highly piezoelectric (Li,K,Na)NbO3 thin films prepared by sol-gel processing (2009)

Lead-free piezoelectric xLiNbO3–(1−x)(K0.52Na0.58)NbO3 (LKNN) (x=0, 0.04, 0.06, and 0.08) thin films on Pt/Ti/SiO2/Si(100) substrates were prepared by a sol-gel method. The effects of the Li substitution content on the crystal structure, microstructure, and electrical properties of LKNN films were investigated. The Li substitution leads to a remarkable improvement in the piezoelectric properties of the films. The LKNN film with an optimized Li substitution of x=0.06 showed a high local effective piezoelectric coefficient d33∗ of 192 pm/V, which is comparable to the piezoelectric performance of Pb(Zr,Ti)O3 films. An enhanced ferroelectricity was also obtained in the x=0.06 LKNN film, with a remnant polarization of 9.7 μC/cm2 and a coercive field of 36.5 kV/cm. Furthermore, an in-depth analysis of the leakage current characteristics of the LKNN films was also conducted in this study.
A Convenient Preparation of Multi‐Spectral Microparticles by Bacteria‐Mediated Assemblies of Conjugated Polymer Nanoparticles for Cell Imaging and Barcoding (2011)

A novel technique was developed for preparing encoded multicolour microparticles based on the self-assembly of bacteria and conjugated polymer nanoparticles (CPNs) by a very simple and time-saving manner. These bacteria-CPNs microparticles show multicolor emissions by tuning FRET efficiencies among CPNs under single excitation wavelength and can be successfully applied for cell imaging and optical barcoding.
Splitting the unit delay [FIR/all pass filters design] (1996)

A fractional delay filter is a device for bandlimited interpolation between samples. It finds applications in numerous fields of signal processing, including communications, array processing, speech processing, and music technology. We present a comprehensive review of FIR and allpass filter design techniques for bandlimited approximation of a fractional digital delay. Emphasis is on simple and efficient methods that are well suited for fast coefficient update or continuous control of the delay value. Various new approaches are proposed and several examples are provided to illustrate the performance of the methods. We also discuss the implementation complexity of the algorithms. We focus on four applications where fractional delay filters are needed: synchronization of digital modems, incommensurate sampling rate conversion, high-resolution pitch prediction, and sound synthesis of musical instruments.
Parallel progressive multiple sequence alignment on reconfigurable meshes (2011)

To our knowledge, this is the first time the progressive multiple sequence alignment algorithm is completely parallelized with O(m) run-time. We also provide a new parallel algorithm for the Longest Common Subsequence (LCS) with O(1) run-time using O(n3) processing units. This is a big improvement over the current best constant-time algorithm that uses O(n4) processing units.
Role of probiotics <i>Bifidobacterium breve</i> and <i>Lactobacillus rhamnosus</i> on inflammation lung in an experimental model of chronic obstructive pulmonary disease (2019)

Introduction Chronic pulmonary obstructive disease (COPD) is defined as an abnormal inflammatory response of the lungs to noxious particles or gases, mainly cigarette smoke. Thus, new therapeutic approaches are of unquestionable relevance. Without a specific treatment for COPD patients the use of probiotics via supplementation of diet can be a promising target. This project aims to investigate the beneficial effects of Bifidobacterium breve (Bb) and Lactobacillus rhamnosus (Lr) probiotics in lung inflammatory process in mice in a model of lung emphysema. Methods This study was approved by the Ethics Committee of the UNIFESP. The COPD was induced by cigarette smoke inhalation of 14 cigarette per day, twice a day, 7 times/week during 60 days in C57Bl/6 mice. The mice were treated with Lr and Bb at the same time. The pro‐inflammatory mediators as IL‐6, TNF, IL‐1 β, CXCL1, CXCL8, CXCL10, KC, CXCL9, CXCL11 and anti‐inflammatory as IL‐10 in bronchoalveolar lavage fluid (BALF) were measured by ELISA. The expression of mRNA of the MMP9 and MMP12, NF‐κB, STAT3 and TLR 2,4 and 9 in lung were analyzed by quantitative RT‐PCR. The NF‐κB was also analyzed by immunolocalization. The lung tissue was used for histological and morphometric analyzes. Results Bb and Lr attenuated the cellularity in BALF and reduced the pro‐inflammatory cytokines and inversely increased the anti‐inflammatory. Also, the probiotics reduced the expression of MMP9 and 12, NF‐κB, STAT3 and TLR 2,4 and 9 in lung. Then, the probiotic also changed the airway remodeling (inflammatory infiltrate, alveolar enlargement, collagen, and elastic fibers). Conclusion This study points out that the probiotics decreased the cellularity on the BALF and the expression of the main transcription factors as a consequence they also reduced pro‐inflammatory cytokines and inversely increase anti‐inflammatory. These results contribute to the understanding of Bb and Lr modulator activities. Support or Funding Information Financial Support: Foundation for Research Support of the State of São Paulo (FAPESP) This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Gel‐free mass spectrometry‐based high throughput proteomics: Tools for studying biological response of proteins and proteomes (2006)

Revolutionary advances in biological mass spectrometry (MS) have provided a basic tool to make possible comprehensive proteomic analysis. Traditionally, two-dimensional gel electrophoresis has been used as a separation method coupled with MS to facilitate analysis of complex protein mixtures. Despite the utility of this method, the many challenges of comprehensive proteomic analysis has motivated the development of gel-free MS-based strategies to obtain information not accessible using two-dimensional gel separations. These advanced strategies have enabled researchers to dig deeper into complex proteomes, gaining insights into the composition, quantitative response, covalent modifications and macromolecular interactions of proteins that collectively drive cellular function. This review describes the current state of gel-free, high throughput proteomic strategies using MS, including (i) the separation approaches commonly used for complex mixture analysis; (ii) strategies for large-scale quantitative analysis; (iii) analysis of post-translational modifications; and (iv) recent advances and future directions. The use of these strategies to make new discoveries at the proteome level into the effects of disease or other cellular perturbations is discussed in a variety of contexts, providing information on the potential of these tools in electromagnetic field research.
Vision-based side vehicle detection from a moving vehicle (2010)

In this paper, a side vehicle detection system with real-time on-board vision is proposed. The system employs camera vision to detect side moving vehicles, and provides necessary warning to drivers and passengers when the vehicle is making lane change. Based on SURF, feature detection and comparison are applied to find the same features between two consecutive images and calculate the feature vectors. Further image analysis is performed based on the feature vectors to determine whether there are side moving vehicles. If any side moving vehicle is detected, the system will apply inverse perspective projection technique to estimate the positions of surrounding vehicles in Cartesian space. Then, the system will generate on-screen signs of safety, warning, or danger to inform drivers and passengers based on the estimated distance to side moving vehicles. The approach has been successfully validated in real traffic environments by performing experiments with two CCD cameras mounted on top of side mirrors of a roadway moving vehicle.
Endophyte-Host Associations in Forage Grasses. III. In vitro Inhibition of Fungi by Acremonium coenophialum (1985)

Click to increase image sizeClick to decrease image sizeKey Words: Acremonium coenophialumFestuca arundinaceagrowth inhibition
Soft decision Viterbi decoding for holographic memory systems (2002)

We have shown soft decision Viterbi decoding for holographic memory systems in which data pages consist of two-dimensional array of convolutional code sequences. It is an advantage of soft decision decoding that an extra coding gain could be obtained in comparison with simple thresholding or hard decision decoding.