gebhart/patrepeval huggingface dataset:
Phenotypic analysis of peripheral blood monocytes isolated from patients with rheumatoid arthritis. (1992)

The expression of CD14, Fc gamma receptor I (Fc gamma RI), Fc gamma RII, and HLA-DR on peripheral blood monocytes from patients with rheumatoid arthritis (RA) was studied to investigate their nature and their role in the pathogenesis of rheumatoid synovitis. Peripheral blood mononuclear cells obtained from 9 patients with active RA, 8 patients with RA in complete remission, and 14 healthy individuals, were stained with various monoclonal antibodies and analyzed on a fluorescence activated cell sorter. The expression of CD14 as well as Fc gamma RI and Fc gamma RII was upregulated on peripheral blood monocytes from patients with active RA, although the expression of HLA-DR was not increased. In addition, the expression of Fc gamma RI and Fc gamma RII on monocytes was still upregulated in patients with RA in complete remission, whereas the expression of CD14 on monocytes was normalized in these patients. These results indicate that peripheral blood monocytes in patients with active RA are already activated to express higher densities of CD14. In addition, our observation that CD14 density was increased on a subset of circulating blood monocytes in active RA, that HLA-DR was not significantly altered and that Fc gamma RI and Fc gamma RII were increased in both active and inactive RA is not compatible with the expected actions of interferon gamma. Finally, it is suggested that peripheral blood monocytes in patients with RA may have intrinsic abnormalities as evidenced by the enhanced expression of Fc gamma R, which is repeatedly observed regardless of the disease activity of RA.
Preparation of 2-(2<i>H</i>-Benzotriazol-2-yl)phenols by the Reduction of 2-[(2-Nitrophenyl)azo]phenols with Thiourea<i>S,S</i>-Dioxide (1986)

The reduction of 2-[(2-nitrophenyl)azo]phenols 1 with thiourea S,S-dioxide and sodium hydroxide in a mixture of isopropyl alcohol and water at reflux provide, 2-(2H-benzotriazol-2-yl)phenols 3 in excellent yields.
Generalized Role-Based Access Control for Securing Future Applications (2000)

As computing technology becomes more pervasive and broadband services are\ndeployed into residential communities, new applications will emerge for the\nhome and community environment. These applications will assist people in a\nvariety of daily activities by enabling them to create, access, and\nmanipulate information about the residents and resources in their homes. In\na connected community, resources in the home and information about the\nresidents of the home will be remotely accessible to both residents and\nguests, as well as to potentially malicious users. These new applications,\nas well as their users and environment, pose new security challenges. The\nchallenges stem from two factors: the nature of the home itself---a private\nspace with a wealth of personal and sensitive information---and the limited\ntechnical knowledge and capabilities of the home's residents.\n\nWe are addressing the problem of securing applications that will access and\ncontrol information resources in the home of the future. Specifically, we\nare designing a security system based on a paradigm called Generalized\nRole-Based Access Control (GRBAC). GRBAC is an extension of traditional\nRole-Based Access Control (RBAC). It enhances traditional RBAC by\nincorporating the notion of object roles and environment roles, with the\ntraditional notion of subject roles. These new types of roles allow one to\ndefine rich, easy-to-understand security policies without having significant\ntechnical knowledge of the underlying computer systems that implement those\npolicies. In this paper, we motivate the need for GRBAC, provide a\nhigh-level description of it and demonstrate its usefulness and flexibility\nvia several example applications.
A Data Hiding Algorithm for H.264/AVC Video Streams Without Intra-Frame Distortion Drift (2010)

Intra-frame distortion drift is a big problem of data hiding in H.264/AVC video streams. Based on a thorough investigation of this problem, a novel readable data-hiding algorithm, which can embed data into the quantized discrete cosine transform (DCT) coefficients of I frames without bringing any intra-frame distortion drift into the H.264/advanced video coding (AVC) video host, is presented in this paper. We exploit several paired-coefficients of a 4 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,\times\,$</tex></formula> 4 DCT block to accumulate the embedding induced distortion. The directions of intra-frame prediction are utilized to avert the distortion drift. It is proved analytically and shown experimentally that the proposed algorithm can achieve high embedding capacity and low visual distortion. Performance comparisons with other existing schemes are provided to demonstrate the superiority of the proposed scheme.
Thrombopoietin Protects the Brain and Improves Sensorimotor Functions: Reduction of Stroke-Induced MMP-9 Upregulation and Blood—Brain Barrier Injury (2010)

This study was conducted to determine the protective efficacy and mechanisms of thrombopoietin (TPO) intervention in experimental focal stroke. Male rats underwent 2 hours of left middle cerebral artery occlusion (MCAO) followed by 22 hours of reperfusion. Vehicle or TPO (0.03 to 1.00 μg/kg) was administered intravenously immediately after reperfusion. Brain infarct and swelling, neurologic deficits, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), TPO and c-Mpl (TPO receptor) mRNA, MMP-9 enzyme activity and protein expression, and the integrity of the blood-brain barrier (BBB) were subsequently measured. MCAO reperfusion produced a large infarct and swelling after stroke. Thrombopoietin significantly reduced these in a dose-dependent manner. The most effective TPO dose, 0.1 μg/kg, when administrated immediately or 2 hours after reperfusion, significantly reduced infarct and swelling and ameliorated neurologic deficits after stroke. Stroke-induced increases in cortical MMP-9 mRNA, enzyme activity and protein expression, TIMP-1 mRNA, and Evans blue extravasation were reduced by TPO intervention. Thrombopoietin did not alter cortical TPO or c-Mpl mRNA expression, blood pressure, heart rate, blood hematocrit, or platelets. This is the first demonstration of TPO's efficacy in reducing ischemic brain injury and improving functional outcome, partly by inhibiting the stroke-induced increase in MMP-9 and the early, negative effects on the BBB.
Exercise Training Stimulates Ischemia-Induced Neovascularization via Phosphatidylinositol 3-Kinase/Akt-Dependent Hypoxia-Induced Factor-1α Reactivation in Mice of Advanced Age (2010)

ST can improve neovascularization in response to hypoxia via a phosphatidylinositol 3-kinase-dependent mechanism that is mediated by the HIF-1 alpha/vascular endothelial growth factor/MMP-2 pathway in advanced age.
Pregnancy and Multiple Sclerosis (1994)

<h3>Objective:</h3> To conduct a prospective assessment of pregnancy on women with multiple sclerosis (MS), focusing on pregnancy outcome and relapses during gestation and up to 6 months after delivery. <h3>Design:</h3> Expected numbers of relapses were based on data for (1) "self-controls": the mothers ("cases") themselves prior to becoming pregnant and (2) "matched controls": female patients with MS "matched" to the mothers for year of birth, age of MS onset, MS type, MS course, and initial MS symptom(s). <h3>Setting:</h3> Cases and controls were identified from an ambulatory care MS clinic that serves the province of British Columbia, Canada. <h3>Patients or Other Participants:</h3> Women with a diagnosis of MS who attended the MS clinic during 1982 through 1986 and subsequently became pregnant during 1982 through 1989 inclusive were included in this study as cases. Matched controls were women with MS who attended the MS clinic during the same period but did not become pregnant. <h3>Results:</h3> No significant increase in relapse rate was found for cases during the first two trimesters of gestation. The number of relapses was significantly less than expected during the third trimester compared with matched controls (ϰ<sup>2</sup>=6.80,<i>df</i>=1,<i>P</i><.02), but not compared with self-controls (ϰ<sup>2</sup>=3.39,<i>df</i>=1,<i>P</i>>.05). The observed number of relapses for the 6 months after delivery did not differ significantly from expected (self-controls:ϰ<sup>2</sup>=2.84,<i>df</i>=2,<i>P</i>>.05; matched controls: ϰ<sup>2</sup>=1.76,<i>df</i>=2,<i>P</i>>.05). <h3>Conclusion:</h3> These data suggest that neither pregnancy nor the 6-month period after delivery is a risk factor for relapse in MS. They are consistent with previous observations that, in the long term, pregnancy does not influence subsequent MS disability.
A contract-based component model for embedded systems (2004)

Component-based software development is becoming mainstream for conventional applications. However, components can be difficult to deploy in embedded systems because of QoS (nonfunctional) requirements. This work presents an approach to building software for embedded systems, based on the use of component in combination with contracts. The contracts specify both the functional properties and QoS properties of the different components in the system. This is especially important in embedded systems, since they are resource constrained. We propose a component model for embedded systems, which is based on four level contracts. And we formalize the first three level contracts by using pi calculus and its type system, allowing us to specify composition and to reason about the compatibility and substitutability of the components.
Role and analysis of monocyte subsets in cardiovascular disease (2016)

Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.
Efficient and accurate structured light algorithm for direct measurement of cylindrical surface parameters (1997)

The recognition of surface shapes using structured light is an important component of many industrial vision systems. The iterative correction algorithm (ICA) for the recognition of cylindrical objects is based upon a predictor-corrector approach which utilizes an initial estimate for the surface parameters, followed by iterative parameter refinement. A predicted passive image is generated using the current surface parameter estimates and significant features are extracted and compared with those in the true passive image. The estimated surface parameters are corrected based upon feature disparities. In this paper, the ICA is enhanced with a new method for computing passive-image point coordinates and tested. Future research directions are indicated.
3. Theory of Ordinary Differential Equations (1995)

The theory of numerical methods for ordinary differential equations is closely associated with certain aspects of the analytic theory of these equations. These aspects are highlighted in this chapter, which is the last preparatory chapter of the book. In the first section, we dispense with some of the more basic theoretical considerations concerning solutions of initial and boundary value problems. Some fundamental existence and uniqueness results are given. Of course, our purpose here is not to duplicate the efforts of a basic text in ODEs. Thus we merely review these results.
Experimental investigation of mass analysis using an island of stability with a quadrupole with 2.0% added octopole field (2007)

We describe experimental investigations of mass analysis using an island of stability with a linear quadrupole with a 2.0% added octopole field. The island is formed by auxiliary quadrupole excitation. The experiments confirm the results of previous computer simulations (Konenkov et al., J. Am. Soc. Mass Spectrom. 2007; 18: 826-834). With the resolving direct current (dc) applied to the quadrupole so that the Mathieu parameter a > 0, conventional mass analysis with applied radio-frequency (rf) and dc and no auxiliary excitation is possible. In this case, use of an island of stability yields similar peak shape and resolution. However, with the polarity of the resolving dc reversed, so that a < 0, only very low resolution can be obtained; the added octopole prevents conventional mass analysis. By using a stability island when a < 0, the resolution is substantially improved. In this case the use of an island allows mass analysis under conditions where the added octopole field severely degrades conventional analysis. The experiments also confirm the position of the island predicted by the simulations.
External labeling of galactose in surface membrane glycoproteins of the intact myelin sheath. (1976)

The molecular organization of surface galactose residues in glycoproteins of the intact myelin sheath was investigated using the enzymatic membrane probe, galactose oxidase. Rat spinal cords treated under physiological conditions with this nonpermanent probe were labeled specifically in galactose residues by reduction with tritiated sodium borohydride. The enzymatically modified proteins from isolated myelin were analyzed electrophoretically and their specific radioactivities determined. Results indicated tritium label associated with a surprising variety of high molecular weight proteins. The most extensively labeled peak corresponded to the major myelin glycoprotein as indicated by the coincidence of tritium label with that of [14C]fucose used as an internal marker for the glycoproteins. The radioactivity associated with this protein was 1.1 to 2.7 times higher after treatment with galactose oxidase when compared to reduction in the absence of the enzyme and 1.4 to 4.8 times higher when oxidized and reduced after prior treatment with neuraminidase. The results suggest a complex heterogeneity of minor glycoproteins associated with isolated myelin. It is concluded that from this complexity of glycoproteins, a major glycoprotein is at least partially localized on the external surface of either the intact myelin sheath or the closely associated oligodendroglial plasma membrane. Such a localization of this glycoprotein and the probable localization of the other glycoproteins enhances their potential role in specific interactions in the process of mpyelination or myelin maintenance.
Marinitoga okinawensis sp. nov., a novel thermophilic and anaerobic heterotroph isolated from a deep-sea hydrothermal field, Southern Okinawa Trough (2007)

A novel thermophilic and sulfur-reducing heterotrophic bacterium, strain TFS10-5(T), was isolated from a deep-sea hydrothermal field in Yonaguni Knoll IV, Southern Okinawa Trough. Cells of strain TFS10-5(T) were motile rods, 1.5-5 microm in length and 0.5-0.8 microm in width. Strain TFS10-5(T) was an obligately anaerobic heterotroph and sulfur-reduction stimulated growth. Growth was observed between 30 and 70 degrees C (optimum at 55-60 degrees C), pH 5.0-7.4 (optimum at pH 5.5-5.8), 1.0-5.5 NaCl % (optimum at 3.0-3.5 %). The fatty acid content was C(16 : 0) (71.0 %), C(16 : 1) (6.0 %), C(18 : 0) (21.4 %) and C(18 : 1) (1.6 %). The G+C content of the genomic DNA was 28 mol%. 16S rRNA gene sequence analysis indicated that strain TFS10-5(T) belongs to the genus Marinitoga. Based on the physiological and phylogenetic features of the new isolate, strain TFS10-5(T) represents a novel species in the genus Marinitoga for which the name Marinitoga okinawensis sp. nov. is proposed. The type strain is TFS10-5(T) (=JCM 13303(T)=DSM 17373(T)).
The automated clearinghouse system: moving toward electronic payment (1994)

Clearinghouses (Banking)
Preparation and properties of annelated pyridines (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and properties of annelated pyridinesRandolph P. Thummel and Dalip K. KohliCite this: J. Org. Chem. 1977, 42, 16, 2742–2747Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/jo00436a019https://doi.org/10.1021/jo00436a019research-articleACS PublicationsRequest reuse permissionsArticle Views774Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Octane-Enhancing, Zeolitic FCC Catalysts: Scientific and Technical Aspects (1989)

(1989). Octane-Enhancing, Zeolitic FCC Catalysts: Scientific and Technical Aspects. Catalysis Reviews: Vol. 31, No. 3, pp. 215-354.
Towards social network analytics for understanding and managing enterprise data lakes (2016)

We have built a tool for inspecting and managing data lakes. The motivations for creating this tool are 1) schema discovery (determining links pertinent to solving a data analysis problem), 2) discovering high risk links in data schemas that give rise to Information Security problems and 3) discovering high value relationships enabling data asset curation. The tool works by extracting metadata from the Hive database on a shared-tenancy instance of Hadoop, which contained a multi-terabyte real-world data asset. We use this metadata to calculate a graph of the relationships between the entities based on column matching. This allows us to apply Social Network Analysis (SNA) techniques in order to discover meaningful properties of the accumulated data. For example to extract previously unknown relationships between data entities. The challenges and the agenda for future research are also provided.
Biomarkers in chronic graft-versus-host disease (2011)

Chronic graft-versus-host disease (cGVHD ) is a leading cause of allogeneic hematopoietic stem-cell transplantation-related mortality and morbidity. It is an immune-mediated disorder that can target almost any organ in the body, often with devastating consequences. The immune-suppressive medications currently used to treat it are equally toxic and are often not very effective. At this time, our understanding of its pathophysiology is limited. The discovery of potential biomarkers offers new possibilities in the clinical management of cGVHD. They could potentially be used for diagnosing cGVHD, for predicting or evaluating response to therapy and for unique insights into the pathophysiology underlying the clinical manifestations of cGVHD. Understanding the biological origins of these biomarkers can help us construct a more comprehensive and clinically relevant model for the pathogenesis of this disease. In this article, we review existing evidence for candidate biomarkers that have been identified in the framework of how they may contribute to the pathophysiology of cGVHD. Issues regarding the discovery and application of biomarkers are discussed.
New application of Se-Ge glasses to silicon microfabrication technology (1976)

A selective etching effect due to photoexposure of Se-Ge glass films was found. The possibilities of applying this phenomenon to the patterning of layers for silicon device processing and for the fabrication of photomasks were investigated. The results showed that the Se-Ge glass has certain advantages in these applications.
Transfer and Regulation of Expression of Chimeric Genes in Plants (1985)

Plant gene vectors derived from the Ti plasmid of Agrobactehum tumefaciens (Zambryski et al. 1983) were used to introduce a number of chimeric genes into tobacco plants. The actual genes involved in these studies were chosen to serve as models for investigating the involvement of 5′ upstream sequences and 3′ downstream sequences in the regulation of gene expression in plants.
ENDOMETRIOSIS (1939)

Endometriosis, or adenomyoma, does not occur frequently as a clinical entity. However, it can no longer be regarded as a pathologic curiosity. Cullen in 1,283 cases of myoma found adenomyoma in 73, or 5.7 per cent. MacCarty and Blackman at the Mayo Clinic reported a series of 3,398 cases of fibromyoma, in which 211, or 6.4 per cent were instances of endometriosis. Tyrone reported similar statistics. Sampson reported 332 laparotomies, with endometrial implants in 98 or 29 per cent. This percentage is high, but endometriosis is his specialty and he has constantly been looking for these lesions. His classic work has established endometriosis as an important condition. Statistics show that in the majority of cases the condition is undiagnosed before operation. With this point in mind, I reviewed the literature and analyzed the cases of endometriosis observed at the St. Francis Hospital and the Sedgwick County Hospital from 1931 to
Photochemical Generation of Nitric Oxide from 6-Nitrobenzo[<i>a</i>]pyrene (2001)

Photolabile 6-nitrobenzo[a]pyrene (6-nitroBaP) released nitric oxide (NO) under visible-light irradiation. The generation of NO and the concomitant formation of the 6-oxyBaP radical were confirmed by ESR. BaP quinones were also detected as further oxidized products of the 6-oxyBaP radical. No such photodegradation was observed with other nitrated BaPs, such as 1-nitroBaP and 3-nitroBaP. DNA-strand breakage, caused by photoexcited 6-nitroBaP, was closely related to its NO-releasing activity. MO calculations of nitrated BaP suggest that the perpendicular conformation of the nitro substituent to the aromatic ring is important for the release of NO with light. These findings may be useful for the development of a new type of NO donor.
Organizational Communication in Telework: Towards Knowledge Management (2001)

Smooth communication through Face-to-face communication across hierarchy has been currently recognized as a critical method for organizational knowledge sharing and knowledge creation.However, these previous research findings are not applicable to telework environment which has much limited face-to-face communication compared with the traditional organization.Although knowledge creation researchers always emphasize on face-to-face communication, research in organizational communication in distributed environment such as telework, are very rare in this field.Further, this research has discussed KM in telework, based on only existing literature, and has not done any empirical analysis.To study knowledge management in telework, we investigate organizational communication in telework.This paper focuses on communication across organizational hierarchy.To achieve the aim of this research, we analyze teleworker's job related communication data that is collected through log-sheets from two telework groups, and then investigate their communication patterns.Finally, based on our findings, we suggest some implications and hypotheses.