gebhart/patrepeval huggingface dataset:
Oral proteasome inhibitor (NPI-0052) enhances sensitivity to combination Gemcitabine and Erbitux in a pancreatic cancer xenograft model (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

4943 

Pancreatic cancer is one of the most resistant cancers to chemotherapy and irradiation. A variety of resistance mechanisms have been demonstrated in pancreatic cancer including the activation of nuclear transcription factor kappa B (NF-κB) and the dysregulation of the epidermal growth factor receptor (EGFR). We have previously demonstrated in vitro that the proteasome inhibitor NPI-0052 suppresses both constitutive and chemotherapy-induced NF-κB activation, but does not stabilize p53 expression, suggesting that treatment induced responses are mediated through p53-independent pathways. The current study was performed to determine if oral administration of a potent proteasome inhibitor NPI-0052 (Nereus Pharmaceuticals, San Diego) could alter the sensitivity to the combination treatment of gemcitabine (Gemzar, Eli Lily, Indianapolis, IN) and the antibody to EGFR (Erbitux, Imclone, Princeton, NJ) in a pancreatic cancer xenograft model. To determine the effect of proteasome inhibition on treatment response, panc-1 tumors were established by injecting 5 x 106 cells in the flank of female nude mice (nu/nu, 4-5 wks, 18-20g). Treatments were initiated once the tumors reached a mean diameter of 10 mm. Treatment groups (7 mice/group) received twice-weekly combination treatment with Erbitux 33mg/kg i.p., Gemzar 80mg/kg, and/or NPI-0052 0.25mg/kg. We found that the addition of NPI-0052 to the different treatment regimens resulted in an enhanced tumor growth response, including a 2-fold greater response to gemcitabine alone (p<0.001,T test), a 1.8-fold greater response to treatment with gemcitabine/Erbitux (p<0.01), and a 1.3-fold enhanced response to treatment with NPI-0052 alone compared to gemcitabine alone (p<0.05). These results demonstrate that the addition of NPI-0052 significantly enhanced tumor growth response to all treatments studied. Additional studies are underway to evaluate the potential of using orally administered NPI-0052 as an adjunct to combination chemo-and molecular therapy in pancreatic cancer.



![Figure][1] [1]: pending:yes
Hierarchical interconnection structures for field programmable gate arrays (1997)

Field programmable gate arrays (FPGA's) suffer from lower density and lower performance than conventional gate arrays. Hierarchical interconnection structures for field programmable gate arrays are proposed. They help overcome these problems. Logic blocks in a field programmable gate array are grouped into clusters. Clusters are then recursively grouped together. To obtain the optimal hierarchical structure with high performance and high density, various hierarchical structures with the same routability are discussed. The field programmable gate arrays with new architecture can be efficiently configured with existing computer aided design algorithms. The k-way min-cut algorithm is applicable to the placement step in the implementation. Global routing paths in a field programmable gate array can be obtained easily. The placement and global routing steps can be performed simultaneously. Experiments on benchmark circuits show that density and performance are significantly improved.
Stimulation of germinal center B lymphocyte proliferation by an FDC-like cell line, HK (1995)

To identify the signals given to the germinal center (GC) B cells by FDC, we have established an FDC-like cell line, HK. HK cells have the important functions of FDC, which are the preferential binding and stimulation of GC B cells. Cell-cell interaction between IgD- B cells and HK cells resulted in the rescue of these cells from apoptosis, whereas the majority of unbound B cells or B cells cultured in the absence of HK cells underwent apoptosis. We investigated the effects of HK cells on the subpopulations of tonsillar B lymphocytes that are at different stages of maturation and differentiation. The subpopulations of tonsillar B cells were purified by panning and/or MACS according to the surface expression of IgD, CD38, and CD44. Although HK cells alone did not stimulate B cell proliferation, HK cells in the presence of either anti-mu or anti-CD40 significantly enhanced the proliferation of B cells. The data show that HK cells preferentially bind, rescue, and stimulate GC B cells (IgD-CD38+) generating CD38-CD44+ memory B cells. The costimulation activity of HK cells is also provided in a form of soluble factor(s). Hence, the phenotypic and functional analysis of HK cells suggests that these cells may be derived from FDC.
A Comparative Study on Phytochemical Investigation and Antioxidant Activity of Poly herbal Mixture of Ocimum canum and Pongamia pinnata hydro-alcoholic Leaf Extracts (2012)

Free radicals are implicated for many diseases including diabetes mellitus, arthritis, cancer, aging, etc. In the treatment of these diseases, antioxidant therapy has gained utmost importance. Reactive oxygen Species (ROS) is a metabolic side product of oxidative stress process which causes several diseases like atherosclerosis, cancer, etc. In defense of ROS, anti-oxidants play a key role in combatting them. As the process of aging increases the level of anti-oxidant in our body decreases and thereby needs utmost attention for its repair process which is generally administered externally. Many herbal remedies individually or in combination have been recommended in various medical expositions for the cure of di fferent diseases. Plant products serve a best source for controlling these activities by its own metabolic pathway. Currently there has been an increased interest globally to identify antioxidant compound that are pharmacologically potent and have low or no side effects. As plants are source of natural antioxidants, much attention has been gain to plants. The quest for natural antioxidants for dietary, cosmetic and pharmaceutical uses has become a major industrial and scientific research challenges over the last two decades. A variety of free radical scavenging antioxidants exists within the body in which many of them are derived from dietary sources like fruits, vegetables and teas. Thus in this aspect three plants namely Pongamia pinnata (Karanj) and Ocimum canum (KalaTulsi) were taken up for the study. Both the plants have been recognized in di fferent system of traditional medicines for the treatment of di fferent diseases and ailments of human beings. In this study, Antioxidant activity of all the hydro-alcoholic extracts was determined by various antioxidant assays. In all the testing, a significant correlation existed between concentrations of the extract and percentage inhibition of free radicals. These findings suggest that the hydro-alcoholic extracts are able to scavenge free radicals, by either hydrogen or electron donating mechanisms, and can therefore act as primary antioxidants. The antioxidant property may be related to the phenols and flavonoids present in the extracts. When all three extracts were mixed together in equal proportion, in same concentration it gives synergistic effect in percentage inhibition with respect to antioxidant property.
Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea. (1991)

A characteristic feature of fibroblasts cultured from affected skin areas of patients with systemic sclerosis (SSc) and localized scleroderma (morphea) is excessive activation of collagen biosynthesis. To elucidate the nature of fibroblast activation in scleroderma we have studied the expression of 3 noncollagenous connective tissue components, osteonectin, small dermatan sulfate proteoglycan (proteoglycan II, decorin), and transforming growth factor-beta 1 (TGF-beta 1), by measuring their mRNA levels in fibroblast cultures from 6 patients with SSc and 3 with morphea. A clear correlation was observed between the increase in type I collagen and osteonectin mRNA in these cell lines. The apparent overproduction of osteonectin by scleroderma fibroblasts is in accordance with the suggested activation of osteonectin expression during tissue remodeling. The levels of decorin mRNA showed marked variation in the cell lines, but were in no correlation with collagen or osteonectin mRNA. The levels of TGF-beta 1 mRNA were found to be slightly elevated in fibroblasts grown from affected scleroderma skin. This may suggest that this potent activator of collagen production has a role during the initial activation of dermal fibroblasts both in SSc and morphea.
Effects of deposition temperature on Parylene-C properties (2013)

This paper reports the study of in-situ deposition temperature (ranging from 20°C to 80°C) effects on Parylene-C properties in terms of glass transition temperature (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ), β-relaxation temperature (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">β</sub> ), Young's modulus and crystallinity (including crystallite size). The results show that the Parylene-C (PA-C) thin film deposited at higher deposition temperature exhibits higher T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> and T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">β</sub> , revealing that the movement of the molecular backbones is further frozen and restricted. It is physically consistent with the data showing that higher deposition temperature induces greater degree of crystallinity and larger Young's modulus. With the new knowledge, Parylene-C thin film with properties tailored to various requirements could be achieved by choosing the proper deposition temperature.
Net absorption and utilization of nitrogenous compounds across ruminal, intestinal, and hepatic tissues of growing beef steers fed dry-rolled or steam-flaked sorghum grain1 (2002)

Our objectives were to determine effects of grain processing on splanchnic (gut tissues and liver) N metabolism and whole-body N balance by growing steers and to ascertain the relative contributions of ruminal and intestinal tissues to net absorption and utilization of N-containing nutrients. Seven beef steers (348 kg initial BW), surgically implanted with appropriate catheters, were fed diets containing 77% steam-flaked (SF) or dry-rolled (DR) sorghum grain. Blood flows and net output or uptake of ammonia N, urea N, and alpha-amino N (estimate of amino acids) were measured across portal-drained viscera (PDV or gut tissues) and intestinal, ruminal, hepatic, and splanchnic tissues (PDV + hepatic). The experimental design was a crossover between DR and SF diets, with six samplings of blood at 2-h intervals on 2 d for each steer. Nitrogen intake (139 +/- 3 g/d), output in urine (43 +/- 2 g/d), and retention (40 +/- 3 g/d) were similar for both processing treatments. When steers were fed SF sorghum compared to DR sorghum, N retention as a percentage of N intake was numerically greater (P < 0.12), output of fecal N was numerically lower (P < 0.13), and urinary urea N was lower (P < 0.04). For SF vs DR, net uptake of alpha-amino N by liver was higher (P < 0.04; 20 vs 9 g/d) and was numerically lower (P < 0.16) for ruminal tissues (15 vs 33 g/d). Feeding steers SF compared to DR tended to increase net transfer (cycling) of blood urea N to PDV (57 vs 41 g/d; P < 0.07), increased cycling to intestinal tissues (15 vs 6 g/d; P < 0.05), and numerically increased transfer to ruminal tissues (42 vs 32 g/d; P < 0.12) but did not alter other net output or uptake of N across splanchnic tissues. Total urea N transfer (blood + saliva) was similar for both treatments. Net uptake of alpha-amino N by ruminal tissues was about 30% of the net amount of alpha-amino N absorbed across the intestinal tissues. In summary, most of the blood urea N cycled from the liver to gut tissues was transferred to ruminal tissues for potential microbial protein synthesis, and the net ruminal utilization of alpha-amino N was about 30% of that absorbed from intestinal tissues. Feeding growing steers SF compared to DR sorghum diets numerically increased whole-body N retention (percentage of N intake) by about 15% and tended to increase transfer of blood urea N to the gut by about 40%, which could increase the supply of high-quality microbial protein for absorption.
Broadband spectral responses in visual cortex revealed by a new MEG denoising algorithm (2015)

Introduction. Recently, intracranial EEG recordings in human and microelectrode recordings from animals have shown that sensory stimuli evoke a broadband elevation in the spectral power of field potentials. This broadband signal is of interest as it correlates with multiunit activity and the fMRI signal. Here we asked whether stimulus-related broadband responses can be reliably measured using MEG. Because extracranial measurements like MEG have multiple global noise sources and relatively low signal-to-noise ratio, we developed a denoising technique that helps reveal the broadband signal of interest. Methods. Subjects viewed 12-Hz contrast-reversing patterns presented either in the left, right, or full visual field, up to 11º eccentricity. Responses in MEG sensors were summarized as an evoked response (12-Hz amplitude) and broadband responses (mean of the log power between 60–150 Hz, excluding stimulus harmonics). A denoising algorithm developed for fMRI (‘GLMdenoise’; Kay et al. 2013) was adapted for MEG. The algorithm separated MEG sensors into those that were visually responsive and those were not (the ‘noise pool’) based on the evoked responses. Using PCA, the noise pool time-series were then summarized as several global noise regressors, which were projected out from the time series of all sensors. Finally, the broadband responses were re-computed from the denoised data. Results. In all subjects, broadband responses were reliably measured in sensors over occipital cortex. The spatial pattern of activation depended on the stimulus, with lateralized stimuli producing bigger responses in contralateral sensors. The signal-to-noise of the broadband responses in visual channels more than doubled as a result of denoising. Conclusions. Spatially localized broadband responses can be measured with MEG from human visual cortex. A new algorithm for denoising MEG data facilitates detection of this signal. Future applications of the denoising algorithm include other measures such as narrow-band oscillations and extension to EEG. Meeting abstract presented at VSS 2015
Fast eigenspace decomposition of correlated images (2000)

We present a computationally efficient algorithm for the eigenspace decomposition of correlated images. Our approach is motivated by the fact that for a planar rotation of a two-dimensional (2-D) image, analytical expressions can be given for the eigendecomposition, based on the theory of circulant matrices. These analytical expressions turn out to be good first approximations of the eigendecomposition, even for three-dimensional (3-D) objects rotated about a single axis. In addition, the theory of circulant matrices yields good approximations to the eigendecomposition for images that result when objects are translated and scaled. We use these observations to automatically determine the dimension of the subspace required to represent an image with a guaranteed user-specified accuracy, as well as to quickly compute a basis for the subspace. Examples show that the algorithm performs very well on a number of test cases ranging from images of 3-D objects rotated about a single axis to arbitrary video sequences.
Correction: Klotho Suppresses Cardiomyocyte Apoptosis in Mice with Stress-Induced Cardiac Injury via Downregulation of Endoplasmic Reticulum Stress (2013)

Cardiomyocyte apoptosis is a common pathological alteration in heart disease which results in systolic dysfunction or sudden death. Klotho is a novel anti-aging hormone. We tested the effects of klotho on cell apoptosis in isoproterenol-treated cardiomyocytes. In BALB/c mice, cardiac injury was induced by subcutaneous injection of isoproterenol (5mg/kg, for 9days, sc). Klotho (0.01 mg/kg, every other day for 4days, ip) was administered to determine the changes in isoproterenol-induced apoptosis. Mouse heart was harvested at day 2, day 5, and day 9 after isoproterenol injection. Isoproterenol induced cardiac apoptosis and endoplasmic reticulum (ER) stress in a time-dependent manner. However, klotho partly reversed isoproterenol-induced cardiac apoptosis and ER stress. These same effects were observed in cultured cardiomyocytes. Furthermore, the results also showed that SB203580, a p38 inhibitor, and SP600125, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduced cardiomyocyte apoptosis and ER stress, however, klotho suppressed isoproterenol-induced activation of p38 and JNK. Taken together, these results indicated that cardioprotection by klotho was related to the attenuation of ER stress and ER stress-induced apoptosis, at least partly, through suppressing activation of the p38 and JNK pathway.
Promotion of wound healing using adipose-derived stem cells in radiation ulcer of a rat model (2013)

We established a modified rat model of radiation-induced wounds and demonstrated that ASCs accelerate wound-healing.
Inhibition of TATA-Binding Protein Function by SAGA Subunits Spt3 and Spt8 at Gcn4-Activated Promoters (2000)

SAGA is a 1.8-MDa yeast protein complex that is composed of several distinct classes of transcription-related factors, including the adaptor/acetyltransferase Gcn5, Spt proteins, and a subset of TBP-associated factors. Our results indicate that mutations that completely disrupt SAGA (deletions of SPT7 or SPT20) strongly reduce transcriptional activation at the HIS3 and TRP3 genes and that Gcn5 is required for normal HIS3 transcriptional start site selection. Surprisingly, mutations in Spt proteins involved in the SAGA-TBP interaction (Spt3 and Spt8) cause derepression of HIS3 and TRP3 transcription in the uninduced state. Consistent with this finding, wild-type SAGA inhibits TBP binding to the HIS3 promoter in vitro, while SAGA lacking Spt3 or Spt8 is not inhibitory. We detected two distinct forms of SAGA in cell extracts and, strikingly, one lacks Spt8. Conditions that induce HIS3 and TRP3 transcription result in an altered balance between these complexes strongly in favor of the form without Spt8. These results suggest that the composition of SAGA may be dynamic in vivo and may be regulated through dissociable inhibitory subunits.
Research progress of Ubc9 in tumorigenesis (2015)

Ubc9 is the unique E2 conjugating enzyme in Small Ubiquitin-like modifier (SUMO) pathway, which plays a key role in the SUMOylation. Researchers found that Ubc9 is overexpressed in many human cancers and Ubc9 is pivotal in tumorigenesis and tumor development, which implies that Ubc9 may be a target for tumor therapy. This review focuses on the relationship of Ubc9 with tumorigenesis and tumor development, and particularly discusses the reseach advances of Ubc9 blockers or inhibitors in tumor treatment.


Key words: 
Ubc9; SUMO; Tumor
From chatter to headlines (2012)

We propose a new methodology for recommending interesting news to users by exploiting the information in their twitter persona. We model relevance between users and news articles using a mix of signals drawn from the news stream and from twitter: the profile of the social neighborhood of the users, the content of their own tweet stream, and topic popularity in the news and in the whole twitter-land.
Analysis and improved performance of RPR protection (2005)

Resilient Packet Ring (RPR, IEEE 802.17) is designed with a protection mechanism aiming at restoring traffic on the ring within 50 ms in case of a link or station failure. In this article, we evaluate RPR protection with respect to service disruption, packet reordering and packet loss. Different error scenarios are simulated, with both steering and wrapping protection. Unfortunately, the 50 ms restoration time guarantee can not always be met if in order delivery of packets is required, since RPR uses a quite long (default 40 ms) topology stabilisation period to avoid packet reordering. We suggest a novel protection mechanism, that does not have to wait for the new topology to be stable, and that gives sub 50 ms restoration for all traffic. We also show that for in order delivery of packets, our new mechanisms discards a very low number of packets compared to the mechanism of the RPR standard.
An optical standing-wave interferometer for displacement measurements (2003)

Laser interferometers have become an important instrument for the measurement of displacement. In future, there is likely to be ever greater importance set on those measuring tasks which use sensors taking up very little space. One solution, proposed here, is a standing-wave interferometer, with a novel photoelectric detector. The latter is 'partially transparent and photoelectrically active', and scans the intensity profile of an optical standing-wave pattern. Arranging two of these transparent photoelectric detectors on the optical axis of the standing wave with the phase shifted permits bidirectional fringe counting. The transparent photoelectric detectors are basically pin-photodiodes with transparent contacts. Two sets of measurements were obtained, the first on a single transparent photoelectric detector and the second on a pair of transparent photoelectric detectors in the standing-wave pattern, and the results are discussed. It is shown that two phase-shifted photoelectric signals (sine and cosine) from two transparent photodetectors in different spatial positions on the optical axis of the standing wave can be received, and that the phase relation between the signals is a function of the distance.
Effect of cyclosporin A on lymphopoiesis. III. Augmentation of the generation of natural killer cells in bone marrow transplanted mice treated with cyclosporin A (1991)

The effects of cyclosporin A (CsA) on the generation of NK cells were studied using syngeneic bone marrow transplanted mice subsequently treated with CsA (BMT/CsA mice). In contrast to a severe reduction in T cells that was reported previously, these mice exhibited a marked enhancement of splenic NK activity. The enhanced NK activity was mediated by NK1.1+, Thy-1- cells as assessed by antibody plus complement treatment, and was concomitant with an absolute increase in the numbers of NK1.1+ cells as assessed by flow cytometry. Because the depletion of host-derived, mature NK cells by injection of anti-asialo GM1 antibody before bone marrow reconstitution did not affect the enhancement of NK activity, CsA appeared to augment the generation of NK cells from bone marrow precursors. To investigate a possible relationship between the enhancement of NK activity and the maturational arrest of T cells in the thymus induced by CsA, mice were thymectomized, followed by irradiation, bone marrow reconstitution, and CsA treatment. These mice exhibited as strong enhancement of splenic NK activity as BMT/CsA mice, suggesting that the CsA-induced effect on NK cells is distinct from its effect on T cell development in the thymus. Taken together, these results are the first demonstration of the positive effect of CsA on NK cell generation and may be of importance in clinical bone marrow transplantation.