gebhart/patrepeval huggingface dataset:
Digitalization of existing continuous control systems (1984)

The problem of converting existing continuous-data control systems into digital control systems is considered. The objective of this paper is to develop a computer-aided method for synthesizing the pulse-transfer function of the digital controller. This is done by matching the frequency response of the digital control system to that of the continuous system with a minimum weighted mean-square error. Formulas for computing the parameters of the digital controller are obtained as a result. The design technique is illustrated aith a numerical example, and a comparison with previous methods is also presented.
MedMaker: a mediation system based on declarative specifications (2002)

Mediators are used for integration of heterogeneous information sources. We present a system for declaratively specifying mediators. It is targeted for integration of sources with unstructured or semi-structured data and/or sources with changing schemas. We illustrate the main features of the Mediator Specification Language (MSL), show how they facilitate integration, and describe the implementation of the system that interprets the MSL specifications.
Adsorption of Aliphatic Alcohol and Sulfonated Dye Mixture on Air/Water Interface (1994)

The equilibrium surface tension of the aqueous solution of aliphatic alcohol and sulfonated dye mixture was measured as a function of the total molarity and mole fraction of dye of the mixture under atmospheric pressure at 298. 15 K. The systems used were n-butanol (BuOH) and C. I. Direct Red 39 (DR-39), and n-pentanol (PeOH) and C. I. Acid Orange 7 (AO-7) mixtures. In the former, the surface-activity of the alcohol was lower than that of the mixed dye, but in the latter, that of the alcohol was higher. By applying Motomura's thermodynamic equation, the total surface density and composition of the mixed adsorbed film were evaluated numerically. In the BuOH and DR-39 mixture system, the mixed adsorbed film abounded in DR-39 over the whole composition range of solution, while in the PeOH and AO-7 mixture system, the mixed adsorbed film abounded in PeOH. The same phenomena were recognized for the benzyl alcohol and acid dye mixture system. These results showed that the composition of the mixed adsorbed film was predominant in the more surface-active component.
Hyperhomocysteinemia inhibits post-injury reendothelialization in mice (2005)

We have established a convenient and accurate mouse model of carotid injury in which the reendothelialization process can be precisely quantified. In addition, we have observed impaired reendothelialization and increased neointimal formation in severe HHcy mice. The capacity of Hcy to inhibit proliferation and migration of EC may be responsible for impaired reendothelialization and contribute to arteriosclerosis in HHcy.
Physical maps of the streptococcal bacteriophage A25 and C1 genomes (1989)

A physical map of the group A streptococcal bacteriophage A25 genome was constructed using data obtained from restriction enzyme digestion analysis of purified DNA. Phage A25 was 34.6 kb in size and was digested with several enzymes which generated the following number of fragments: AvaI (3), EcoRI (2), HindIII (4), HaeII (10), HindII (22), HpaI (11), and PvuII (8). Restriction enzymes BamH1, PstI, and SaI did not cleave phage A25 DNA. A physical map of the group C streptococcal phage C1 genome was also constructed. Phage C1 was 16.9 kb in size and was cleaved by the following enzymes to give the indicated number of fragments: EcoRI (8), HaeII (10), HaeII (4), HaeII (10), HindIII (5), HpaI (8), PvuII (3), and SalI (2). Restriction enzymes AvaI, AvaII, BamH1, EcoRV, HpaII, and PstI did not cleave phage C1 DNA.
Face modeling and recognition in 3-D (2004)

We demonstrate a complete and automatic system to perform face authentication by analysis of 3D facial shape. In this live demonstration of the system, the subject is first enrolled, and given a unique identifier. Subsequently, the user's identity is verified by providing the reference identifier. Our approach is to be contrasted with traditional face recognition methods, which compare pictures of faces. We also analyzed the image quality requirements in order to generate a good quality 3D reconstruction from stereo.
Involvement of p300 in constitutive and HIV‐1 Tat‐activated expression of glial fibrillary acidic protein in astrocytes (2010)

HIV-1 Tat protein is an important pathogenic factor in HIV-1-associated neurological diseases. One hallmark of HIV-1 infection of the central nervous system (CNS) is astrocytosis, which is characterized by elevated glial fibrillary acidic protein (GFAP) expression in astrocytes. We have shown that Tat activates GFAP expression in astrocytes [Zhou et al., (2004) Mol Cell Neurosci 27:296-305] and that GFAP is an important regulator of Tat neurotoxicity [Zou et al., (2007) Am J Pathol 171:1293-1935]. However, the underlying mechanisms for Tat-mediated GFAP up-regulation are not understood. In this study, we reported concurrent up-regulation of adenovirus E1a-associated 300 kDa protein p300 and GFAP in Tat-expressing human astrocytoma cells and primary astrocytes. We showed that p300 was indeed induced by Tat expression and HIV-1 infection and that the induction occurred at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter. Using siRNA, we further showed that p300 regulated both constitutive and Tat-mediated GFAP expression. Moreover, we showed that ectopic expression of p300 potentiated Tat transactivation activity and increased proliferation of HIV-1-infected astrocytes, but had little effect on HIV-1 replication in these cells. Taken together, these results demonstrate for the first time that Tat is a positive regulator of p300 expression, which in turn regulates GFAP expression, and suggest that the Tat-Egr-1-p300-GFAP axis likely contributes to Tat neurotoxicity and predisposes astrocytes to be an HIV-1 sanctuary in the CNS.
The kinetics of hydrolysis of synthetic glucuronic esters and glucuronic ethers by bovine liver and <i>Escherichia coli</i> β-glucuronidase (1973)

1. The relative rates of hydrolysis of synthetically prepared beta-d-glucuronic esters [aglycone: benzoic acid, veratroic (3,4-dimethoxybenzoic) acid, indol-3-ylacetic acid and ethylbutyric acid], and beta-d-glucuronic ethers (aglycone: phenolphthalein, p-nitrophenol, 3,4-dimethoxyphenol, 3,4-dimethoxybenzyl alcohol) by commercial preparations of beta-glucuronidase from bovine liver and Escherichia coli were investigated. The rates of hydrolysis of all compounds tested were followed by measuring the formation of glucuronic acid under conditions which do not affect the glycosidic ester bond. 2. The pH profiles of the substrates in reaction with the enzyme from both sources were determined, and substrate-saturation curves at the optimal pH for each substrate were constructed; double-reciprocal plots of activity against concentration were linear. 3. Comparison of kinetic data indicates that neither the type of sugar-aglycone linkage, nor the aglycone structure alone can explain the observed K(m) and V(max.) values. 4. alpha-d-Glucuronic esters of benzoic and veratroic acid resisted hydrolysis by beta-glucuronidase from both sources.
Blockade of Secondary Lymphoid Tissue Chemokine Exacerbates <i>Propionibacterium acnes-</i> Induced Acute Lung Inflammation (2001)

Chemokine-chemokine receptor interaction plays an essential role in leukocyte/dendritic cell (DC) trafficking in inflammation and immune responses. We investigated the pathophysiological roles of secondary lymphoid tissue chemokine (SLC; CCL21) and macrophage inflammatory protein-2 (MIP-2) in the development of acute pulmonary inflammation induced by an intratracheal injection of Propionibacterium acnes in mice. Immunohistochemical studies revealed that SLC was constitutively expressed in the peribronchial areas and perivascular lymphatics in normal mice. MIP-2-positive cells were observed in alveolar spaces in mice challenged with P. acnes. Both neutralization Abs against MIP-2 and CXC chemokine receptor 2 alleviated the P. acnes-induced pulmonary inflammation when injected before P. acnes Ag challenge. On the other hand, polyclonal anti-SLC Abs (pAbs) exacerbated the pulmonary inflammation. The numbers of mature DCs (MHC class II +, CD11c+, and CD86+) as well as macrophages and neutrophils in the P. acnes Ag-challenged lungs were increased, whereas the number of CD4+ T cells, including memory T cells, was decreased. The numbers of mature and proliferating CD4+ T cells (bromodeoxyuridine(+)CD4+) in regional lymph nodes were decreased in mice injected with anti-SLC pAbs compared with those in mice treated with control Abs. An in vitro proliferation assay confirmed the impairment of the Ag-specific T cell response in regional lymph nodes of mice treated with anti-SLC pAbs. These results indicate for the first time a regulatory role for SLC-recruited mature DCs in bridging an acute inflammatory response (innate immunity) and acquired immunity in the lung.
Segmentation and classification of TV news articles based on speech dictation (2003)

We propose a method to automatically segment continuous TV news speech into articles and classify them into 10 topics based on speech dictation techniques using speaker independent triphone HMMs and word bigram. The proposed method is composed of keyword selection and topic function which computes the similarity between topics and the analytical period in spoken sentences. In the keyword selection, relative mutual information is proposed and compared with other 5 measures. It showed the highest score 81.8% and 87.0% in topic classification and topic boundary detection respectively. In the topic function, we compared four methods and the normalized association showed the best scores in topic segmentation and classification.
Metabolic response of Acylation Stimulating Protein to an oral fat load. (1989)

Acylation Stimulating Protein (ASP) is a small (mol wt 14,000), basic (pI 9.0) protein present in human plasma. When examined in vitro with normal human cultured skin fibroblasts and adipocytes, ASP appears to be the most potent stimulant of triglyceride synthesis yet described. In this study, a competitive ELISA assay for ASP has been developed using immunospecific polyclonal antibodies, and ASP levels have been measured in seven normal subjects. Following an oral fat load, a sustained significant increase in ASP occurs, whereas after an oral glucose load, ASP levels do not change significantly. These responses are entirely opposite to those of insulin, which rises sharply but transiently after an oral glucose load but is unchanged after an oral fat load. Both the fasting and peak ASP levels were significantly related to the postprandial lipemia. These data provide the first in vivo evidence that Acylation Stimulating Protein may play an important physiological role in the normal response to an oral fat load.
Isolation of epsilon-haemoglobin-chain positive fetal cells with micromanipulation for prenatal diagnosis (2005)

The results of our study suggest that micromanipulation and QF-PCR analysis of anti-haemoglobin-epsilon fluorescent antibody stained fetal cells from maternal blood can be useful in prenatal diagnosis to detect fetal gender and promising to be improved to detect chromosomal abnormalities.
Angiotensin-converting enzyme insertion/deletion polymorphism and systemic lupus erythematosus: a metaanalysis. (2006)

This metaanalysis of 2962 subjects showed there is a lack of association of the ACE I/D polymorphism with SLE and LN.
Synthesis and Biological Activity of Isomers of N-[Bis(2-chloroethyl)aminobenzoyl]glutamic Acid<sup>1a,b</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Biological Activity of Isomers of N-[Bis(2-chloroethyl)aminobenzoyl]glutamic Acid1a,bS.-C. J. Fu, H. Terzian, and S. CravenCite this: J. Med. Chem. 1964, 7, 6, 759–762Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/jm00336a018https://doi.org/10.1021/jm00336a018research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cross-hybridization modeling on Affymetrix exon arrays (2008)

We provide mappings between human and mouse exon array probes and off-target transcripts and provide software extending the GeneBASE program for generating gene-level expression estimates including the cross-hybridization correction http://biogibbs.stanford.edu/~kkapur/GeneBase/.
Identification of <i>Malassezia</i> species from pityriasis versicolor in Indonesia and its relationship with clinical characteristics (2008)

Pityriasis versicolor (PV) is a chronic superficial fungal disease caused by Malassezia spp. The incidence is as high as 30-40% in tropical climates. Previous studies indicate that the geographic factor has influence on the main species isolated from PV. Our aim was to identify Malassezia spp. from PV patients in Indonesia and their correlation to clinical characteristics. Isolates of Malassezia were collected from 98 PV patients (62 males and 36 females). Identification was based on morphological observation and biochemical evaluation. Leeming Notman agar was used as isolation culture medium. The biochemical evaluation consisted of specimen culture onto Sabouraud dextrose agar, Cremophor EL, Esculin, Dixon's agar at 37 degrees C and catalase reaction. The isolates found were Malasseziafurfur (42.9%), M. sympodialis (27.5%), M. globosa (13.3%), M. slooffiae (7.7%), M. obtusa (7.7%) and M. restricta (2.2%), and 7.14% specimens were unidentified. There was no statistically significant association between Malassezia spp. and demographic characteristics and clinical characteristics of the patients. Unlike reports from temperate climate countries, this study in Indonesia found M. furfur as the most frequently isolated Malassezia spp. in PV patients.
Open Rotor Designs for Low Noise and High Efficiency (2013)

Building upon the successes of the UDF® program in the 1980’s, open rotor designs for high flight speed efficiency and low community noise have been developed at GE in collaboration with NASA and the FAA. Targeting a narrow body aircraft with 0.78 cruise Mach number, the cost-share program leveraged computational fluid dynamics (CFD), computational aero-acoustics (CAA), and rig scale testing to generate designs that achieved significant noise reductions well beyond what was attained in the 1980’s while substantially retaining cruise performance. This paper presents overall propeller net efficiency and acoustic assessments of GE’s modern open rotor designs based on measured rig data and the progression of the technology from the 1980’s through the present. Also discussed are the effects of aft rotor clipping, inter-rotor spacing, and disk loading. This paper shows how the two-phase design and scale model wind tunnel test program allowed for test results of the first design phase to feed back into the second design phase, resulting in 2–3% improvement in overall propeller net efficiency than the best efficiency design of the 1980’s while nominally achieving 15–17 EPNdB noise margin to Chapter 4 (when projected to full scale for a prescribed aircraft trajectory and installation). Accounting for trades and near term advancements, such a propulsion system is projected to meet the goal of 26% fuel burn reduction relative to CFM56-7B powered narrow body aircraft.
Diversity in glycerol metabolism of methylotrophic yeasts (1987)

Methylotrophic yeasts showed 3 different patterns in regard to the initial step of glycerol dissimilation. Hansenula polymorpha DL-1 had activities of NAD+-linked glycerol dehydrogenase (GDH) and glycerol kinase (GK), which were induced by glycerol and methanol and by glycerol, respectively. Hansenula ofunaensis had the GDH activity, which was induced by glycerol but not by methanol. Candida boidinii No. 2201 had the GK activity, which was induced by glycerol. It was concluded that the phosphorylative pathway in C. boidinii No. 2201, the oxidative pathway in H. ofunaensis, and both the pathways in H. polymorpha DL-1 may be essential for glycerol dissimilation.
Performance analysis of sampling switches in voltage and frequency domains using Volterra series (2004)

In any data converter system, the linearity of the sampling switch is a very critical parameter, especially for wideband sigma-delta modulators. Distortion introduced in the sampling instance directly degrades the quality of the input signal. In this paper we present analyses of a set of sampling switches in the frequency and voltage domains in order to find the most linear type for wide baseband excitation. Volterra series analysis is adopted to find the frequency behavior of the switches. The theoretical results are verified by circuit simulations in a 0.35 /spl mu/m CMOS process. It is found that the bootstrap sampling switch is a very attractive candidate, especially for frequencies near f/sub s//2.
Postoperative nausea and vomiting. (1992)

One of the most common and distressing side effects after surgery performed under general anaesthetic is postoperative nausea and vomiting (PONV). Indeed, for many patients, PONV is the most distressing feature of their operation and some may become anxious about having another operation because of this. The medical and economic consequences of PONV can also be serious. This article looks at the incidence, causes, and current management of PONV, and the development of a new drug for the prevention and treatment of this.
Synthesis of Amorphous Boron Nitride by Pressure Pyrolysis of Borazine (1989)

Amorphous BN that contains hydrogen could be synthesized by pressure pyrolysis of borazine below 700°C at 100 MPa. The fraction of B and N bonded to H in the pyrolysis product could be controlled by changing the pressure pyrolysis condition. The pyrolysis product at 700°C and 100 MPa showed formation of B‐N‐B bonds of the hexagonal structure in the amorphous state with some B‐H and N‐H bonding remaining. Spherulitic BN could be prepared only by pyrolysis below 400°C and 100 MPa. The yield of amorphous BN from borazine was as high as about 60% by this pressure pyrolysis. Amorphous BN formed from borazine could be readily converted to cubic BN by reacting it with AIN at 1200°C and 6.5 GPa.
Viscoelastic Properties of Microtubule Networks (2007)

Microtubules are filamentous protein biopolymers found in eukaryotic cells. They form networks that guide active intracellular transport and support the overall cell structure. Microtubules are very rigid polymers, with persistence lengths as large as a millimeter. As such, they constitute an example of rodlike polymers, whose mechanical and rheological properties are as yet poorly understood. We measure the linear and nonlinear viscoelastic properties of isotropic solutions of purified microtubules, as well as networks permanently cross-linked with biotin−NeutrAvidin. In the linear regime both solutions and networks are soft elastic materials with elastic moduli on the order of a few pascals. The elastic moduli show a power-law dependence on tubulin concentration, cT, with G‘ ∼ cTν, where ν ≈ 1.4 for solutions and increases slightly to ν ≈ 1.6−1.8 for networks. At large deformations, we observe a concentration-dependent yield stress. The rheology of microtubule solutions cannot be explained by the Doi−Edwards model, which treats noninteracting rigid rods. Instead, they show behavior very similar to the permanently cross-linked networks, suggesting the presence of effective cross-linking even in pure microtubule solutions. We develop a simple model based on transient cross-linking interactions between microtubules to interpret the rheological response. We also calculate a lower bound estimate of the strength of this interaction. Our data provide a framework with which to understand the dynamics and mechanics of more physiological networks of microtubules with microtubule-associated cross-linking and motor proteins, and ultimately to understand the role of microtubules in cell mechanics.
Constant weight codes for correcting symmetric errors and detecting unidirectional errors (1993)

Proposes two classes of constant weight codes, which can be used for correcting t symmetric errors and simultaneously detecting all unidirectional errors. Codes in the first class are in quasi-systematic form and codes in the second class are in systematic form. Since each codeword of codes in both classes can be divided into a data part and a parity check part, the proposed codes have the merit of easily mapping messages into codewords.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Out-of-step prediction logic for wide-area protection based on an autoregressive model (2005)

This work describes a new out-of-step prediction logic based upon the autoregressive model (AR model), which is a kind of time-series analysis. The oscillation after the clearance of a severe fault is modeled using the mth-order of the AR model, of which input data are the phase difference of the voltage between substations. The stability of the power system is distinguished using the sign of the real part of the characteristic roots that are given by solving the pulse transfer function of the AR model. That is, a negative sign leads the power system to be judged to fall into unstable status. In this case, the oscillation of the rotor angle of every generator is modeled using the mth-order of the AR model. Where both oscillations include the same components, the power system is predicted to fall into out-of-step status. The new logic is verified using the Y-method, which CRIEPI has developed as a dynamic analysis and which gives good results in the 10-generator western Japan 60 Hz model power system.
Increasing Crop Productivity to Meet Global Needs for Feed, Food, and Fuel (2009)

Global demand and consumption of agricultural crops for food, feed, and fuel is increasing at a rapid pace. This demand for plant materials has been expanding for many years. However, recent increases in meat consumption in emerging economies together with accelerating use of grain for biofuel