gebhart/patrepeval huggingface dataset:
Phenotypic screening for heart rate variability in the mouse (2000)

We developed a technology for heart rate (HR) variability (HRV) analysis in the mouse for characterization of HR dynamics, modulated by vagal and sympathetic activity. The mouse is the principal animal model for studying biological processes. Mouse strains are now available harboring gene mutations providing fundamental insights into molecular mechanisms underlying cardiac electrical diseases. Future progress depends on enhanced understanding of these fundamental mechanisms and the implementation of methods for the functional analysis of mouse cardiovascular physiology. By telemetric techniques, standard time and frequency-domain measures of HRV were computed with and without autonomic blockade, and baroreflex sensitivity testing was performed. HR modulation in the high-frequency component is predominantly mediated by the parasympathetic nervous system, whereas the low-frequency component is under the influence of both the parasympathetic and sympathetic systems. The presented technology and protocol allow for assessment of autonomic regulation of the murine HR. Phenotypic screening for HR regulation in mice will further enhance the value of the mouse as a model of heritable electrophysiological human disease.
Carbohydrates and fertilization: an overview (1997)

Initial sperm-egg binding in mammals involves recognition of glycosylated proteins of egg zonae by glycosylated proteins on sperm surfaces. Egg zona protein structure is relatively simple, and has been strongly conserved. Species specificity must reside in the carbohydrate modifications on the egg surface, and in the co-ordinated assembly of a unique cohort of sperm proteins at capacitation. Fruitful advances have been made along four lines. Oligosaccharide structures capable of binding spermatozoa have been dissected by in-vitro synthesis and binding experiments, informed by the general advance of knowledge of protein glycosylation processes. Site-specific mutagenesis of zona proteins and their expression in tissue culture have identified glycosylation sites involved in species-specific sperm binding. Antibody and lectin labelling studies show a continuing process of remodeling of glycosylated sperm surface epitopes within a set of stable compartments during epididymal transit and capacitation of spermatozoa. Characterization of sperm-egg binding proteins from a variety of mammalian species shows that a different set of effectors induce acrosome reactions in each species, with each set including one or more sugar-recognizing proteins. Sequencing of some of these effectors suggests that each group may form a supermolecular complex to induce a species-specific acrosome reaction, with the functional activities distributed in a species limited or non-limited manner among the individual proteins.
Enhanced Thermal Conductivity of Epoxy–Graphene Composites by Using Non‐Oxidized Graphene Flakes with Non‐Covalent Functionalization (2012)

Homogeneous distribution of graphene flakes in a polymer matrix, still preserving intrinsic material properties, is key to successful composite applications. A novel approach is presented to disperse non-oxidized graphene flakes with non-covalent functionalization of 1-pyrenebutyric acid and to fabricate nanocomposites with outstanding thermal conductivity (∼1.53 W/mK) and mechanical properties (∼1.03 GPa).
Regulation of Cl−/ HCO3−Exchange by Cystic Fibrosis Transmembrane Conductance Regulator Expressed in NIH 3T3 and HEK 293 Cells (1999)

A central function of cystic fibrosis transmembrane conductance regulator (CFTR)-expressing tissues is the secretion of fluid containing 100-140 mM HCO3-. High levels of HCO3- maintain secreted proteins such as mucins (all tissues) and digestive enzymes (pancreas) in a soluble and/or inactive state. HCO3- secretion is impaired in CF in all CFTR-expressing, HCO3--secreting tissues examined. The mechanism responsible for this critical problem in CF is unknown. Since a major component of HCO3- secretion in CFTR-expressing cells is mediated by the action of a Cl-/HCO3- exchanger (AE), in the present work we examined the regulation of AE activity by CFTR. In NIH 3T3 cells stably transfected with wild type CFTR and in HEK 293 cells expressing WT and several mutant CFTR, activation of CFTR by cAMP stimulated AE activity. Pharmacological and mutagenesis studies indicated that expression of CFTR in the plasma membrane, but not the Cl- conductive function of CFTR was required for activation of AE. Furthermore, mutations in NBD2 altered regulation of AE activity by CFTR independent of their effect on Cl- channel activity. At very high expression levels CFTR modified the sensitivity of AE to 4,4'-diisothiocyanatostilbene-2, 2'-disulfonate. The novel finding of regulation of Cl-/HCO3- exchange by CFTR reported here may have important physiological implications and explain, at least in part, the impaired HCO3- secretion in CF.
Aerodynamic drag of modern soccer balls (2013)

Soccer balls such as the Adidas Roteiro that have been used in soccer tournaments thus far had 32 pentagonal and hexagonal panels. Recently, the Adidas Teamgeist II and Adidas Jabulani, respectively having 14 and 8 panels, have been used at tournaments; the aerodynamic characteristics of these balls have not yet been verified. Now, the Adidas Tango 12, having 32 panels, has been developed for use at tournaments; therefore, it is necessary to understand its aerodynamic characteristics. Through a wind tunnel test and ball trajectory simulations, this study shows that the aerodynamic resistance of the new 32-panel soccer ball is larger in the high-speed region and lower in the middle-speed region than that of the previous 14- and 8-panel balls. The critical Reynolds number of the Roteiro, Teamgeist II, Jabulani, and Tango 12 was ~2.2 × 10(5) (drag coefficient, C d ≈ 0.12), ~2.8 × 10(5) (C d ≈ 0.13), ~3.3 × 10(5) (C d ≈ 0.13), and ~2.4 × 10(5) (C d ≈ 0.15), respectively. The flight trajectory simulation suggested that the Tango 12, one of the newest soccer balls, has less air resistance in the medium-speed region than the Jabulani and can thus easily acquire large initial velocity in this region. It is considered that the critical Reynolds number of a soccer ball, as considered within the scope of this experiment, depends on the extended total distance of the panel bonds rather than the small designs on the panel surfaces.
Women with Symptomatic Preterm Birth Have a Distinct Cervicovaginal Metabolome (2017)

Objective The objective was to determine if women with symptoms of preterm labor who ultimately have a spontaneous preterm birth (sPTB) have a distinct cervicovaginal (CV) metabolome compared with women who deliver at term. Study Design A nested case–control study of women presenting with symptoms of preterm labor was performed. CV fluid was collected from women between 22 and 336/7 weeks' gestation. The CV metabolome was compared between women with sPTB (n = 20) and women who delivered at term (n = 30). Global biochemical profiles were determined using ultraperformance liquid chromatography/tandem mass spectrometry. Welch's two-sample t-test was used to identify metabolites that differed significantly. Level of significance was defined as p ≤ 0.05. Results Eighty-eight percent of women were African-American and none had a prior history of sPTB. A total of 301 metabolites were identified in CV fluid. Thirty metabolites were significantly different in women with preterm birth compared with term birth. Two metabolites (mannitol and methyl phosphate) were significantly upregulated, and the remaining 28 metabolites were significantly downregulated and consisted of medium chain-fatty acids and collagen degradation markers. Conclusion The CV metabolome is significantly altered among women who present with preterm labor symptoms and ultimately have a sPTB.
Parallel transmission framework for layered coded multimedia data over spectrally shaped channels (2003)

This paper presents a new parallel transmission framework for reliable multimedia data transmission over spectrally shaped channels using multicarrier modulation. We propose to transmit source data layers of different perceptual importance in parallel, each occupying a number of subchannels. New loading algorithms are developed to efficiently allocate the available resources, e.g. transmitted power and bit rate, to the subchannels according to the source layers they transmit. Instead of making the bit error rate of all the subchannels equal as in most existing loading algorithms, the proposed algorithm assigns different error performance to the subchannels as to achieve unequal error protection for different layers. The channel induced distortion in mean-square sense is minimized. We show that the proposed system can be applied nicely to both fixed length coding and variable length coding. Numerical examples show that the proposed algorithm achieves significant performance improvement comparing to the existing work for spectrally shaped channels commonly used in in ADSL.
EXTRACELLULAR BIOSYNTHESIS OF SILVER NANOPARTICLES USING THE MYCORRHIZAL MUSHROOM TRICHOLOMA CRASSUM (BERK.) SACC.: ITS ANTIMICROBIAL ACTIVITY AGAINST PATHOGENIC BACTERIA AND FUNGUS, INCLUDING MULTIDRUG RESISTANT PLANT AND HUMAN BACTERIA. (2011)

In this study we show for the first time the green biosynthesis of silver nanoparticles with the help of the mycorrhizal mushroom Tricholoma crassum(Berk.) Sacc. This is a simple and reproducible method of silver nanoparticle production using mycelial mats which results in monodispersed nanoparticles of high concentration. The particles were studied with spectrophotometry showing absorbance peak at 440nm. Scanning and transmission electron microscopy showed particles were mostly spherical with a few of hexagonal shape. With a TEM software, histogram was constructed showing the size range of the particles to be of 5 - 50 nm diameter, the average being 21.91nm. These nanoparticles had potent antimicrobial effect on human bacteria E.coli (DH5α) , plant pathogenic bacteria Agrobacterium tumifaciens (LBA4404) and the plant pathogenic fungus Magnaporthe oryzae. Multi-drug resistant (MDR) E.coli was generated by transformation with pUC19 and pZPY112 and selection with 100µg/ml Ampicillin and 35µg/ml Chloramphenicol. A. tumifaciens which is resistant to 25µg/ml Rifampicin was transformed with pCAMBIA2301 and selected with 50µg/ml Kanamycin. The nanoparticles had potent inhibitory effect on these MDR pathogenic bacteria. Thus this source of silver nanoparticles has the potential to be produced on a large scale and find application in the field of medicine and crop protection.
A Video-on-Demand Transmission Scheme for IPTV Service with Hybrid Mechanism (2008)

The video-on-demand (VoD) service over IP based network is increasingly provided with dedicated unicast stream. In the VoD server's point of view, this unicast transmission is simple and makes no problem when there is enough capacity or the service request arrival rate is moderately low. However, in the real world, the video request popularity is highly skewed, so there are often concentrated requests for one particular content and burst requests in case of special events. Those cases are critical for the unicast transmission servers because the server's capacity is limited from its initial design so it results in high service blocking probability. To cope with this problem, we propose a hybrid transmission mechanism with newly proposing "Multi-session Multicasting" algorithm and adaptive session allocation method. The multi-session multicasting algorithm enables to serve unlimited requests within a fixed boundary of the bandwidth consumption and the adaptive video allocation method enables to decide the efficient transmission method for each videos. Therefore, by transmitting highly requested videos through multi-session multicasting and normal videos with unicast, we have achieved improvement on service blocking probability.
Implantation of a Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function and Blood Flow after Acute Myocardial Infarction (2009)

This study was designed to determine if a viable biodegradable three-dimensional fibroblast construct (3DFC) patch implanted on the left ventricle after myocardial infarction (MI) improves left ventricular (LV) function and blood flow. We ligated the left coronary artery of adult male Sprague-Dawley rats and implanted the 3DFC at the time of the infarct. Three weeks after MI, the 3DFC improved LV systolic function by increasing (p < 0.05) ejection fraction (37 +/- 3% to 62 +/- 5%), increasing regional systolic displacement of the infarcted wall (0.04 +/- 0.02 to 0.11 +/- 0.03 cm), and shifting the passive LV diastolic pressure volume relationship toward the pressure axis. The 3FDC improved LV remodeling by decreasing (p < 0.05) LV end-systolic and end-diastolic diameters with no change in LV systolic pressure. The 3DFC did not change LV end-diastolic pressure (LV EDP; 25 +/- 2 vs. 23 +/- 2 mmHg) but the addition of captopril (2mg/L drinking water) lowered (p < 0.05) LV EDP to 12.9 +/- 2.5 mmHg and shifted the pressure-volume relationship toward the pressure axis and decreased (p < 0.05) the LV operating end-diastolic volume from 0.49 +/- 0.02 to 0.34 +/- 0.03 ml. The 3DFC increased myocardial blood flow to the infarcted anterior wall after MI over threefold (p < 0.05). This biodegradable 3DFC patch improves LV function and myocardial blood flow 3 weeks after MI. This is a potentially new approach to cell-based therapy for heart failure after MI.
Analysis of Body Size Measurements for U.S. Navy Women's Clothing and Pattern Design (1979)

Abstract : Data from major anthropometric surveys of U.S. Army and U.S. Air Force women are analyzed with a view toward establishing sizing programs for U. S. Navy women's clothing. Summary statistics, percentile and frequency tables, and measurement descriptions are presented for 49 variables related specifically to clothing design. A high degree of comparability was found between the two measured samples in most dimensions, although the Army women, measured in 1976-77, were found to be slightly taller and heavier than the USAF subjects surveyed in 1968, and to have somewhat larger waists and smaller bust dimensions. Using the data from the two military women's surveys and key dimensions and sizing intervals specified by the Navy Clothing and Textile Research Facility, a sizing analysis was conducted. Several different approaches were tried, but the resulting sizing programs do not satisfactorily cover the measured samples and presumably would be similarly deficient for a U.S. Navy population. The authors recommend the selection of different key dimensions arid sizing intervals suggested by the actual distribution of body size variability in the military women's samples. A limited-objective survey of U.S. Navy women is also recommended for purposes of resolving various noted discrepancies.
Islet activating protein-sensitive guanosine triphosphate-binding protein regulates K+-channels coupled with FMRFamide receptors. (1987)

A neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) induces K+-dependent outward current in Aplysia neurons. Intracellular application of islet activating protein (IAP) irreversibly and selectively blocked this outward current without affecting resting membrane conductance. An injection of GTP gamma S, a nonhydrolyzable analogue of guanosine triphosphate (GTP), caused very slow irreversible increase in K+-conductance of the resting membrane. However, repetitive applications of FMRFamide significantly expedited the effect of GTP gamma S. These results strongly suggest that K+-channel opening induced by FMRFamide is regulated by an IAP-sensitive GTP-binding protein.
A phase 2 clinical trial of <i>nab</i>‐paclitaxel in previously treated and chemotherapy‐naive patients with metastatic melanoma (2009)

nab-Paclitaxel was found to be well tolerated and demonstrated activity in both previously treated and chemotherapy-naive patients with MM. The response rate, PFS, and survival compared favorably with current standard dacarbazine therapy and combination therapies for melanoma. nab-Paclitaxel therapy of MM should be investigated further in controlled clinical trials. Cancer 2010. (c) 2010 American Cancer Society.
Migration to Intermediate XML for Electronic Data (MIXED): Repository of Durable File Format Conversions (2011)

Data Archiving and Networked Services (DANS), the Dutch scientific data archive for the social sciences and humanities, is engaged in the Migration to Intermediate XML for Electronic Data (MIXED) project to develop open source software that implements the smart migration strategy concerning the long-term archiving of file formats. Smart migration concerns the conversion upon ingest of specific kinds of data formats, such as spreadsheets and databases, to an intermediate XML formatted file. It is assumed that the long-term curation of the XML files is much less problematic than the migration of binary source files and that the intermediate XML file can be converted in an efficient way to file formats that are common in the future. The features of the intermediate XML files are stored in the so-called Standard Data Formats for Preservation (SDFP) specification. This XML schema can be considered an umbrella as it contains existing formal descriptions of file formats developed by others. SDFP also contain schemata developed by DANS, for example, a schema for file-oriented databases. It can be used, for example, for the binary DataPerfect format, that was used on a large scale about twenty years ago, and for which no existing XML schema could be found. The software developed in the MIXED project has been set up as a generic framework, together with a number of plug-ins. It can be considered as a repository of durable file format conversions. This paper contains an overview of the results of the MIXED project.
Potential Use of Silver Nanoparticles as an Additive in Animal Feeding (2010)

Among other uses, metallic silver and silver salts have currently been applied as antimicrobial agents in many aspects of medical industries, such as coating of catheters, dental resin composites and burn wounds, as well as in homeopathic medicine, with a minimal risk of toxicity in humans. However, their use in animal feeding as prebiotics have remain minimised, mostly because of the low cost antibiotics used as growth promoters in the second half of the XX Century. However, after the ban of this practice in the European Community, silver compounds appear as a potential alternative to other already in use, such as organic acids, oligosaccharides, plant extracts, etc. The major concerns about the safe use of an additive in animal feeding are its effective role as antimicrobial, acting selectively over potential pathogens but not over symbiotic microbial communities; a low toxic effect over the animal and its human consumer; and a low risk of environmental pollution. Metallic silver nanoparticles (up to 100 nm) allow for a higher antimicrobial effect than silver salts, are more resistant to deactivation by gastric acids and have a low absorption rate through the intestinal mucosa, thus minimising its potential risk of toxicity. Besides, it has been shown that the doses that promote animal physiological and productive effects are very low (20 to 40 ppm), especially compared to the 10 to 100-fold higher concentration used with other metallic compounds such as copper and zinc, thus precluding a harmful environmental effect. This chapter describes the reasons why silver nanoparticles could be applied to animal feeding, and provides with some available data in this regard. In any case, its registration as feed additive is a previous requisite before being applied in practical conditions.
Pharmacokinetics and Effect of Food on The Bioavailability of Orally Administered Venlafaxine (1997)

Venlafaxine is a unique antidepressant currently under evaluation for treatment of various affective disorders. The pharmacokinetics and relative bioavailability of venlafaxine were evaluated in healthy volunteers after oral administration. The bioavailability of 50 mg of venlafaxine as a tablet relative to a solution was determined in a two-period randomized crossover study. The rate of absorption from the gastrointestinal tract was assessed by the time to peak plasma concentration (tmax), a model-dependent calculation of the first-order absorption rate constant, and a model-independent calculation of mean residence time. The extent of absorption was assessed by peak plasma concentration (Cmax) and area under the concentration-time curve (AUC). No statistically significant differences were observed between the two formulations for either the rate or extent of absorption. Similarly, systemic concentrations of the active O-demethylated metabolite did not significantly differ after administration of the two venlafaxine formulations. AUC ratios indicated that the relative bioavailabilities of the parent drug, and formulation of metabolite were approximately 98% and 92%, respectively, for the tablet versus the solution. A separate study was conducted to examine the influence of food on venlafaxine absorption from the 50-mg tablet. A standard, medium-fat breakfast eaten immediately before drug administration delayed the tmax of venlafaxine but did not affect Cmax or AUC. Therefore the tablet formulation of venlafaxine is bioequivalent to the oral solution, and the presence of food appears to decrease the rate but not the extent of absorption of venlafaxine from the tablet formulation.
Mechanical Force‐Driven Growth of Elongated Bending TiO<sub>2</sub>‐based Nanotubular Materials for Ultrafast Rechargeable Lithium Ion Batteries (2014)

A stirring hydrothermal process that enables the formation of elongated bending TiO2 -based nanotubes is presented. By making use of its bending nature, the elongated TiO2 (B) nanotubular crosslinked-network anode electrode can cycle over 10 000 times in half cells while retaining a relatively high capacity (114 mA h g(-1)) at an ultra-high rate of 25 C (8.4 A g(-1)).
High quantum efficiency annular backside silicon photodiodes for reflectance pulse oximetry in wearable wireless body sensors (2010)

The development of annular photodiodes for use in a reflectance pulse oximetry sensor is presented. Wearable and wireless body sensor systems for long-term monitoring require sensors that minimize power consumption. We have fabricated large area 2D ring-shaped silicon photodiodes optimized for minimizing the optical power needed in reflectance pulse oximetry. To simplify packaging, backside photodiodes are made which are compatible with assembly using surface mounting technology without pre-packaging. Quantum efficiencies up to 95% and area-specific noise equivalent powers down to 30 fW Hz-1/2 cm-1 are achieved. The photodiodes are incorporated into a wireless pulse oximetry sensor system embedded in an adhesive patch presented elsewhere as 'The Electronic Patch'. The annular photodiodes are fabricated using two masked diffusions of first boron and subsequently phosphor. The surface is passivated with a layer of silicon nitride also serving as an optical filter. As the final process, after metallization, a hole in the center of the photodiode is etched using deep reactive ion etch.
Corrector design with active vase mirrors that allows a fixed telescope to access a large region of the sky (1997)

We investigate a family of two-mirror correctors to compensate for the aberrations of a parabolic mirror observing at a large angle from the zenith. We constrain our designs to optical elements that can be built with currently available technology. The secondary and the tertiary mirrors are warped by Zernike polynomials, which we know can be generated with active vase mirrors. The performances of these corrector designs are usable for imagery.