gebhart/patrepeval huggingface dataset:
Characterization of Metakaolinite with Multiple Quantum MAS NMR (2000)

Metakaolinite produced by thermal transformation from kaolinite was studied by 27Al multiple quantum magic angel spinning (MQMAS) NMR technique in addition to 1-dimensional 27Al and 29Si MAS NMR. Our results confirm that 4-, 5-, 6- coordinated aluminum sites co-exit with some distribution of isotropic chemical shifts. This is consistent with amorphous character of metakaolinite observed with X-ray diffraction. In addition, characterization with MQMAS is briefly discussed in comparison with other NMR techniques to identify different aluminum sites especially when peaks are severely overlapped in 1-dimensional 27Al MAS NMR spectra.
The binding of amide substrate analogues to phospholipase A2. Studies by 13C-nuclear-magnetic-resonance and infrared spectroscopy (1992)

(R)-(2-dodecanamidoisohexyl)phosphocholine (DAHPC), labelled with 13C at the amide carbonyl group, has been synthesized and its binding to bovine pancreatic phospholipase A2 (PLA2) studied by n.m.r. and i.r. spectroscopy. Two-dimensional 1H-n.m.r. spectra show that, in the presence of Ca2+, DAHPC binds to the active site of the enzyme in a similar manner to other phospholipid amide substrate analogues. The environment of the labelled carbonyl group has been investigated by a combination of 13C n.m.r. and difference-Fourier-transform i.r. spectroscopy. The carbonyl resonance shifts 3 p.p.m. downfield on the binding of DAHPC to PLA2. The carbonyl absorption frequency decreases by 14-18 cm-1, accompanied by a marked sharpening of the absorption band. These results indicate that the carbonyl bond undergoes significant polarization in the enzyme-ligand complex, facilitated by the enzyme-bound Ca2+ ion. This suggests that ground-state strain is likely to promote catalysis in the case of substrate binding. Simple calculations, based on the i.r. data, indicate that the carbonyl bond is weakened by 5-9 kJ.mol-1. This is the first report of observation of the amide vibration of a bound ligand against the strong background of protein amide vibrations.
Histone modification levels are predictive for gene expression (2010)

Histones are frequently decorated with covalent modifications. These histone modifications are thought to be involved in various chromatin-dependent processes including transcription. To elucidate the relationship between histone modifications and transcription, we derived quantitative models to predict the expression level of genes from histone modification levels. We found that histone modification levels and gene expression are very well correlated. Moreover, we show that only a small number of histone modifications are necessary to accurately predict gene expression. We show that different sets of histone modifications are necessary to predict gene expression driven by high CpG content promoters (HCPs) or low CpG content promoters (LCPs). Quantitative models involving H3K4me3 and H3K79me1 are the most predictive of the expression levels in LCPs, whereas HCPs require H3K27ac and H4K20me1. Finally, we show that the connections between histone modifications and gene expression seem to be general, as we were able to predict gene expression levels of one cell type using a model trained on another one.
Metastatic Breast Tumour Regression Following Treatment by a Gene‐Modified Vaccinia Virus Expressing MUC1 and IL‐2 (2003)

MUC1 is expressed by glandular epithelial cells. It is overexpressed in the majority of breast tumours, making it a potential target for immune therapy. The objectives of the present study were to evaluate the anti‐tumour activity and tolerance of repeated administration of TG1031 (an attenuated recombinant vaccinia virus containing sequences coding for human MUC1 and the immune stimulatory cytokine IL‐2) in patients with MUC1‐positive metastatic breast cancer. This was an open‐label, randomised study comparing two dose levels, 5 × 10E6 and 5 × 10E7 pfu, with 14 patients in each arm. The treatment was administered intramuscularly every 3 weeks for the first 4 doses and every 6 weeks thereafter, until progression. Two patients had a partial tumour regression (>50%), and 15 patients had stable disease as their best overall response until at least the 5th injection. Partial regression lasted for 11 months in one patient and for 12 months in the second patient who then underwent surgical resection of her hepatic metastases. The most frequent adverse events included inflammation at injection site: 7 patients, itching or pain at injection site: 5 patients, and moderate fever: 6 patients. One responding patient developed antinuclear, anti‐DNA, and increased anti‐TPO antibodies after the fifth injection, and which resolved at the end of treatment. The treatment regimes were well tolerated with a low toxicity profile. Although clinical efficacy remains limited, this study demonstrates the potential use of MUC1‐based immune therapy in breast cancer.
Prevalence and population structure of <i>Staphylococcus aureus</i> nasal carriage in healthcare workers in a general population. The Tromsø Staph and Skin Study (2012)

Healthcare workers (HCWs) may be a reservoir for Staphylococcus aureus transmission to patients. We examined whether HCW status is associated with S. aureus nasal carriage and population structure (spa types) in 1302 women (334 HCWs) and 977 men (71 HCWs) aged 30-69 years participating in the population-based Tromsø Study in 2007-2008. Multivariable logistic regression models were used. While no methicillin-resistant S. aureus (MRSA) was isolated, overall, 26·2% of HCWs and 26·0% of non-HCWs were S. aureus nasal carriers. For women overall and women residing with children, the odds ratios for nasal carriage were 1·54 [95% confidence interval (CI) 1·09-2·19] and 1·86 (95% CI 1·14-3·04), respectively, in HCWs compared to non-HCWs. Moreover, HCWs vs. non-HCWs had a 2·17 and 3·16 times higher risk of spa types t012 and t015, respectively. This supports the view that HCWs have an increased risk of S. aureus nasal carriage depending on gender, family status and spa type.
The automated generation of Web documents that are tailored to the individual reader (1997)

Many studies in communication have shown that presenting information in a manner that is tailored to the characteristics of a particular audience can have a significant effect on an individual. Incorporating this kind of tailoring facility in a system for the management and presentation of Web documents would be a very important enhancement of the Web&apos;s current state of development. Our long-term research goal has been to investigate and develop theories of text composition, in particular, computational models of rhetorical structure and lexical semantics, which are particular problems for incorporating style in natural language systems. Recently, we have begun to apply this research to developing Web-based natural language generation systems that can tailor documents to the individual user on demand. Introduction A recent and growing development in Web applications has been the advent of various tools that claim to &quot;customize&quot; access to information on the Web by allowing users to spe...
Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles (2019)

Tobramycin is commonly used to treat Pseudomonas aeruginosa lung infections in patients with Cystic Fibrosis (CF). Tobramycin treatment leads to increased lung function and fewer clinical exacerbations in CF patients, and modestly reduces the density of P. aeruginosa in the lungs. P. aeruginosa resides primarily in the mucus overlying lung epithelial cells and secretes outer membrane vesicles (OMVs) that diffuse through the mucus and fuse with airway epithelial cells, thus delivering virulence factors into the cytoplasm that modify the innate immune response. The goal of this study was to test the hypothesis that Tobramycin reduces the abundance of virulence factors in OMVs secreted by P. aeruginosa. Characterization of the proteome of OMVs isolated from control or Tobramycin-exposed P. aeruginosa strain PAO1 revealed that Tobramycin reduced several OMV-associated virulence determinants, including AprA, an alkaline protease that enhances P. aeruginosa survival in the lung, and is predicted to contribute to the inhibitory effect of P. aeruginosa on Phe508del-CFTR Cl- secretion by primary human bronchial epithelial cells. Deletion of the gene encoding AprA reduced the inhibitory effect of P. aeruginosa on Phe508del-CFTR Cl- secretion. Moreover, as predicted by our proteomic analysis, OMVs isolated from Tobramycin treated P. aeruginosa had a diminished inhibitory effect on Phe508del-CFTR Cl- secretion compared to OMVs isolated from control P. aeruginosa. Taken together, our proteomic analysis of OMVs and biological validation suggest that Tobramycin may improve lung function in CF patients infected with P. aeruginosa by reducing several key virulence factors in OMVs that reduce CFTR Cl- secretion, which is essential for bacterial clearance from the lungs.
Synthesis and characterization of new blue‐greenish electroluminescent materials based on 1,3,4‐oxadiazole‐triazolopyridinone hybrids (2007)

Abstract New functionalized oxadiazole‐triazolopyridinone derivatives were synthesized via arcycloaddition. With the chromophores of triazolopyridinone, the photoluminescence spectra of these compounds in dichloromethane solution showed emission peaks between 430 and 520 nm. Following the spectroscopic studies, and the measurements of cyclic voltammogram, 1,3,4‐oxadiazole‐triazolopyridinone hybrids possess a great potential as highly efficient, blue‐greenish, organic light‐emitting devices materials. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:212–219, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20285
Use of a cocktail of monoclonal antibodies and human complement in selective killing of acute lymphocytic leukemia cells (1986)

Autologous remission bone marrow is a potential source of repopulative stem cells after ablative chemoradiotherapy of tumor patients. Even with remission bone marrow, one major obstacle to use of autologous bone-marrow support is the danger of reinfusing viable tumor cells. This report describes a purging protocol with human complement, which seems suitable for eliminating acute lymphatic leukemia (ALL) cells of the common ALL type. Lysis of ALL blasts is induced with a cocktail of 3 monoclonal antibodies of IgM type (termed VIB-pool). These are directed against the CALLA (CD 10) antigen (VIL-AI antibody) and against 2 different epitopes of the CD24 surface structure (VIB-C5 and VIB-E3 antibodies). The purging efficiency was evaluated with leukemic cell lines of the common ALL type (Reh-6 and Nalm-6) and with blast cells from common ALL patients. Optimal lysis was obtained with antibody and human serum concentrations as low as 1 microgram/ml and 7% respectively. As a standard purging protocol we propose one 20-min incubation at room temperature with antibody followed by two 30-min incubations at 37 degrees C with 25% human complement. In dye exclusion test 99% purging efficiency and in clonogenic assays detecting elimination of up to 5 logs of clonogenic tumor cells 99.99% (= 4 logs) purging efficiency were achieved. Treatment with VIB-pool and human complement had no negative effect on the growth of the normal hemopoietic progenitor cells CFU-GM, CFU-E and BFU-E.
Adeno-associated viral vectors and successful gene therapy, the gap is closing (2000)

Founded in 1683 in Leiden, the Netherlands, Brill is a leading international academic publisher in the Humanities, Social Sciences, International Law, and Biology. With offices in the Netherlands, Germany, Austria, the USA and Asia, Brill today publishes more than 360 journals and 2,000 new books and reference works each year as well as a large number of databases and primary source research collections.
Cellular Migration, Proliferation, and Contraction (1986)

Presently used animal models of proliferative vitreoretinopathy reflect only cell proliferation and contraction. We used an in vitro model that measured cell migration, proliferation, and contraction. The following four drugs were assayed on this system: daunomycin, taxol, colchicine, and cytochalasin B. Daunomycin was the most effective drug against cell proliferation and cell migration but had no effect on cell contraction; taxol and colchicine affected all three parameters. Cytochalasin B was the least effective drug tested.
Device discovery and configuration scheme for Internet of Things (2016)

The term “Internet of Things” (IoT) refers to the expansion of Internet technologies to include smart objects by extensive deployment of exclusively identifiable distributed communication devices. The management of configuration in these devices, in particular, is a challenge due to the high heterogeneity in different communication protocols, communication sequences, and processing capabilities. We propose a device configuration management scheme for IoT inspired by IBM's autonomic control loop. This scheme is capable of discovering sensors despite their heterogeneity in their offered services. Furthermore, by enabling configuration management, dependence of IoT systems on user interference can be minimized.
Loss of miR-200c: A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers (2009)

We focus on unique roles of miR-200c in breast, ovarian, and endometrial cancers. Members of the miR-200 family target ZEB1, a transcription factor which represses E-cadherin and other genes involved in polarity. We demonstrate that the double negative feedback loop between miR-200c and ZEB1 is functional in some, but not all cell lines. Restoration of miR-200c to aggressive cancer cells causes a decrease in migration and invasion. These effects are independent of E-cadherin status. Additionally, we observe that restoration of miR-200c to ovarian cancer cells causes a decrease in adhesion to laminin. We have previously reported that reintroduction of miR-200c to aggressive cells that lack miR-200c expression restores sensitivity to paclitaxel. We now prove that this ability is a result of direct targeting of class III beta-tubulin (TUBB3). Introduction of a TUBB3 expression construct lacking the miR-200c target site into cells transfected with miR-200c mimic results in no change in sensitivity to paclitaxel. Lastly, we observe a decrease in proliferation in cells transfected with miR-200c mimic, and cells where ZEB1 is knocked down stably, demonstrating that the ability of miR-200c to enhance sensitivity to paclitaxel is not due to an increased proliferation rate.
Infants’ visual preference for sex‐congruent babies, children, toys and activities: A longitudinal study (2000)

Sex differences in social behaviour emerge as early as 2 years of age and gender schema theorists have suggested that preverbal infants possess ‘tacit’ knowledge of gender which informs their behaviour. This study examined sex‐congruent preferences using a visual preference paradigm in four domains (babies, children, toys, activities) in a longitudinal study of infants aged 3, 9 and 18 months. At 3 months, infants showed a marginally significant preference for same‐sex babies driven principally by males. Sex‐congruent toy preference was found among males at ages 9 and 18 months. Both sexes preferred masculine activity styles but this effect was significantly stronger among males than females. Gender schema theory requires gendered self‐concept as a precursor to sex‐congruent preference. Infants did not recognize themselves from photographs at any of the ages tested. By 18 months approximately two thirds of infants showed self‐recognition on the rouge test. However, at none of the ages and in none of the domains tested was self‐recognition related to sex‐congruent preference. Cross‐domain consistency of preference was not found. There was evidence of some stability of preference within domains between the ages of 9 and 18 months and this stability was very marked for activity preference.
<i>In vitro</i> cytotoxicities of ionic liquids: Effect of cation rings, functional groups, and anions (2008)

In vitro cytotoxicities were measured for ionic liquids (ILs) containing various cations and anions using the MCF7 human breast cancer cell line. We measured the cytotoxicities of ionic liquids containing the cations pyridinium, pyrrolidinium, piperidinium, or imidazolium with various alkyl chain lengths, and the anions bromide, bis(trifluoromethanesulfone)imide (Tf(2)N), trifluoromethylsulfonate (TfO), or nonafluoromethylsulfonate (NfO). Three new hydrophobic, task-specific ionic liquids (TSILs), namely, [MBCNPip](+)[Tf(2)N](-), [MPS(2)Pip](+)[Tf(2)N](-), and [MPS(2)Pyrro](+)[Tf(2)N](-) designed for metal-ion extraction were also evaluated. IC(50) values of the ionic liquids toward the MCF7 cells ranged from 8 microM to 44 mM. The toxicity depended significantly on the nature of the cations and anions, especially when the cations contained a long side chain. TSILs studied in this work were less toxic than the classical ILs.
Een verjaardagsfeest met de verkeerde jarige (2013)

2013 is het jaar waarin Nederland 200 jaar koninkrijk viert. Volgens het Comité dat belast is met de vormgeving van deze viering (zie www.200jaarkoninkrijk.nl) dienen we de inhuldiging van Willem I als ‘Soeverein vorst der Verenigde Nederlanden’ te vieren als het begin van een aantal belangrijke verworvenheden uit de afgelopen twee eeuwen. Het gaat dan om ‘bestuurlijke stabiliteit in een moderne rechtsstaat’, de ‘internationale oriëntatie’ van Nederland, ‘eenheid in verscheidenheid’, ‘ruimte voor actief burgerschap’ en ‘persoonlijke rechten en vrijheden’. Vooral deze laatste twee verworvenheden wekken verbazing. Wie de Nederlandse politieke en bestuurlijke geschiedenis overziet moet namelijk concluderen dat er in 1813 weinig te vieren was voor voorstanders van actief burgerschap en individuele rechten en vrijheden – deze waren in de grondwetten van 1814 en 1815 bewust beperkt gehouden.
Anti-angiogenic Activity of Tocotrienol (2003)

The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.
Synthesis and in vitro trypanocidal activity of some novel iron chelating agents. (1997)

This report describes the syntheses and in vitro trypanocidal activity of a number of iron (III) chelators against epimastigotes of Trypanosoma cruzi. The compounds examined included a number of lipophilic N-alkyl derivatives of 2-ethyl- and 2-methyl-3-hydroxypyrid-4-ones, N,N'-bis(o-hydroxybenzyl)-(+/-)-trans-1,2-diaminocyclohexane, cyclotetrachromotropylene and four commercially available carboxy derivatives of pyridine, pyrazine, and pyarazole. Benznidazole, the drug clinically used in the treatment of Chagas' disease in humans, served as standard. All compounds were screened in vitro against Trypanosoma cruzi epimastigotes at 50 and 100 micrograms/ml for 72 h of exposure. At 100 micrograms/ml dosage, at least 4 compounds exhibited high epimastigote growth inhibition (65-69%) comparable to benznidazole (72%), whereas 9 compounds showed moderate to fair activity (53-64%) in the in vitro assay. At the lower concentration (50 micrograms/ml), the inhibitory activity of the best of these compounds was reduced significantly (39-48%) compared to the standard drug (59%). The activity of all the carboxylic acids remained in the lower range (4-25%). It is hypothesized that the enhanced activity of some of the compounds is due to their increased lipophilicity which enables them to successfully pass through the cellular membrane of Trypanosoma cruzi epimastigotes. The trypanocidal activities of the most effective compounds were significantly reduced when tested in the presence of added ferric ion.
Trauma care at the University of Mississippi Medical Center: economic & other realities. (1991)

There are a number of complicating factors which do, or have the potential to, impact trauma care at the University of Mississippi Medical Center and the University Hospital. These are (Exhibit 6): Number of Trauma Patients. There are more trauma patients in Mississippi than any single hospital or group of physicians can care for under present circumstances. Type of Trauma Patients. The only Level I center is constantly stressed with trauma patients, many of whom could be adequately treated at other facilities. Hospital Resources. Resources are frequently stretched beyond reasonable limitations. Primary examples include the SICU and nursing personnel on numerous units. Lack of a Trauma Network. The effects of the first three factors are compounded by the lack of a trauma network in the State of Mississippi. Trauma Funding. The lack of trauma funding, on a statewide basis, for equipment and other needed resources impairs the ability of all hospitals (including the University Hospital) to meet the needs of trauma patients. Patient Finances. Tied to the lack of specific funding is the financial case mix of trauma patients. It is simply not financially worthwhile for hospitals or physicians to involve themselves, on a regular basis, in the care of these patients. These issues are related to one another in a complex fashion. Many are beyond the scope of the University Hospital and the University of Mississippi Medical Center to resolve. But, they adversely impact our facilities, and others throughout the state, on a daily basis. As these issues are reviewed and thought about, one final fact should be kept in mind.(ABSTRACT TRUNCATED AT 250 WORDS)
Patient Knowledge Distillation for BERT Model Compression (2019)

Siqi Sun, Yu Cheng, Zhe Gan, Jingjing Liu. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP). 2019.
The vasoconstriction induced by endothelin-1 is mediated only by ETA receptors in mesenteric small resistance arteries of spontaneously hypertensive rats and Wistar Kyoto rats (1997)

The contractile effects of ET-1 on mesenteric small resistance arteries of SHR and WKY rats are mediated mostly by ET(A) receptors, whereas ET(B) receptors play a minor role, if any. It is possible, however, that a vasoconstrictor effect of ET(B) receptors on the smooth muscle could be masked by the concomitant stimulation of endothelial ET(B) vasodilator receptors.
An open circuit voltage decay system for performing injection dependent lifetime spectroscopy (2017)

Of all of the material parameters associated with a semiconductor, the carrier lifetime is by far the most complex and dynamic, being a function of the dominant recombination mechanism, the equilibrium number of carriers, the perturbations in carriers (e.g., carrier injection), and the temperature, to name the most prominent variables. The carrier lifetime is one of the most important parameters in bipolar devices, greatly affecting conductivity modulation, on-state voltage, and reverse recovery. Carrier lifetime is also a useful metric for device fabrication process control and material quality. As it is such a dynamic quantity, carrier lifetime cannot be quoted in a general range such as mobility; it must be measured. The following describes a stand-alone, wide-injection range open circuit voltage decay system with unique lifetime extraction algorithms. The system is initially used along with various lifetime spectroscopy techniques to extract fundamental recombination parameters from a commercial high-voltage PIN diode.