gebhart/patrepeval huggingface dataset:
Expression of NCAM recapitulates tubulogenic development in kidneys recovering from acute ischemia (1999)

Recovery of the kidney from acute renal failure relies on a sequence of events including epithelial cell dedifferentiation and proliferation followed by differentiation and restoration of the functional integrity of the nephron. The factors responsible for, and the significance of, reversion to a less differentiated cell phenotype and its relationship to the proliferative response after ischemia are poorly understood. In an attempt to identify adhesion molecules that may be influential in the recovery process, the expression of neural cell adhesion molecule (NCAM) and markers of epithelial differentiation and proliferation were analyzed at various times after an ischemic insult. In maturing nephrons, NCAM is detectable by immunohistochemistry in renal vesicles, S-shaped bodies, and early tubules. There is minimal cellular NCAM expression in normal tubules of the adult kidney. In contrast, in postischemic kidneys, NCAM expression is abundant in S3 proximal tubule cells 5 days after reperfusion. As in developing tubules, NCAM is concentrated in basal and lateral aspects of cells that have no apical gp330 or dipeptidyl peptidase IV detectable on their brush border. The expression of NCAM is preceded by disassembly of the brush border and proliferation of surviving S3 cells, which is most prominent at 2 days postischemia. NCAM expression persists in some flattened and dedifferentiated cells for up to 7 wk after ischemia. Thus proximal tubule epithelial cells of the postischemic kidney express NCAM in a pattern that recapitulates the expression of NCAM in the developing kidney. Such reversion of phenotype extends at least back to the early stages of renal vesicle formation, and this reversion may represent a critical step in the reestablishment of a normal tubule. NCAM-matrix interactions may mediate the motogenic and mitogenic responses of the dedifferentiated epithelium that are critical to reestablishment of a functional proximal tubule.
Macroscopic analyses of the infrastructure: measurement and visualization of Internet connectivity and performance (2001)

| The robustness and reliability of the Internet is highly dependent on ecient, stable connectivity and routing among networks comprising the global infrastructure. To provide macroscopic insights into Internet topology and performance, the Cooperative Association for Internet Data Analysis (CAIDA) has developed and deployed the skitter tool to dynamically discover and depict global Internet topology and measure performance across speci c paths. We are developing a systematic approach to visualizing the multi-dimensional parameter space covered by
Generation mechanism of residual clamping force in a bipolar electrostatic chuck (2003)

Clamping and residual clamping forces of a Johnsen–Rahbek-type (JR-type) bipolar electrostatic chuck (ESC), which has electrically independent dual electrodes, were measured. Area ratios of the ESC’s two electrodes ranged from 1 to 4.6. It was found that the clamping force per unit area decreases with increasing area ratio and that the residual clamping force per unit area increases with increasing area ratio. To reveal the mechanism of residual clamping force, an equivalent circuit model of a JR-type bipolar ESC was devised. The model showed that the residual clamping force is caused by the residual charge that results from the charge difference in two monopolar ESCs. The charge difference is due to the resistance dependency on voltage of the dielectric layer of the ESC. The wafer voltage calculated from the model agreed well with the voltage measured by an electrostatic voltmeter. It can be concluded that the model is suitable for simulating the performance of a bipolar ESC.
Conference report - air pollution 2006, United Kingdom (2006)

The Fourteenth International Conference on Modelling, Monitoring and Management of Air Pollution, organised by the Wessex Institute of Technology (WIT), was held from 22-24 May 2006 at Ashurst, New Forest, United Kingdom.
Dispersion of Boron Nitride Powders in Aqueous Suspensions with Cellulose (2014)

The dispersion of nitride and carbide ceramic particles in water is difficult, due to the absence of hydroxyl groups on their surface. Boron nitride ( BN ) is not an exception and despite its numerous applications, no effective dispersant has been identified so far. We demonstrate here the dispersion properties of two cellulose derivatives for hexagonal BN powders, hydroxyl ethyl cellulose and methyl cellulose. The effect of particle size and cellulose concentration was investigated. The adsorption of cellulose onto the surface of the BN particles was confirmed by isotherm adsorption. Zeta potential measurements show a charge screening effect of the cellulose The suspensions obtained were highly loaded and stable versus pH , and thus could lead to homogeneous codispersion of BN particles and sintering additives.
Uncovering a multitude of human glucocorticoid receptor variants: an expansive survey of a single gene (2019)

This identification of naturally occurring and stress-induced hGR isoforms, as well as the establishment of an hGR-specific database, may reveal new patterns or suggest areas of interest that will lead to the improved understanding of the human stress response system.
Design of Active Frequency Selective Surface with Curved Composite Structures and Tunable Frequency Response (2017)

We present an active frequency selective surface (AFSS) consisting of a curved composite structure that provides structural stability and robustness. The proposed structure can operate on either the C-band (OFF state) or X-band (ON state) by controlling the PIN diode located between the cross-shaped loop and the inductive stub on the surface. Moreover, it minimizes parasitic couplings through grid-type on/off bias circuits and via holes. Thus, the AFSS guarantees isolation from the unit cell, which is a downside of a previous control technique called reconfigurable frequency selective surface. We analyzed the impact of composite structures and the three-dimensional shape on the AFSS transmission with a foam-core sandwich structure, which is light and mechanically strong, by considering conditions of a real application environment.
Several Azoic Dyes Derived from Catechol (1959)

Dimetyl-, diethyl-, and ethylene ethers of aminocatechol were synthesized. Those were condensed with β-hydroxynaphthoic acid to give azoic coupling components. p-Nitroaniline and 2-chloro-4-nitroaniline were diazotized and coupled with aminocatechol dimethyl- and -diethyl ether to give aminoazo compounds as azoic diazo components, and their coloration and fastness have been invb-stigated.The coupling components synthesized gave nearly the same coloration as that of Naphthol AS-BG, among which ethylene derivative gave a clear blue coloration when combined with Fast Blue BB and its fastness was about the same as that of Naphthol AS-BG. The diazo components generally colored in brownolive green, their fastness was 6 grade for light and superior for washing and rubbing.
Proactive learning (2008)

Proactive learning is a generalization of active learning designed to relax unrealistic assumptions and thereby reach practical applications. Active learning seeks to select the most informative unlabeled instances and ask an omniscient oracle for their labels, so as to retrain the learning algorithm maximizing accuracy. However, the oracle is assumed to be infallible (never wrong), indefatigable (always answers), individual (only one oracle), and insensitive to costs (always free or always charges the same). Proactive learning relaxes all four of these assumptions, relying on a decision-theoretic approach to jointly select the optimal oracle and instance, by casting the problem as a utility optimization problem subject to a budget constraint. Results on multi-oracle optimization over several data sets demonstrate the superiority of our approach over the single-imperfect-oracle baselines in most cases.
Bactericidal antibodies after vaccination with the Norwegian meningococcal serogroup B outer membrane vesicle vaccine: a brief survey. (1991)

Results from the serum bactericidal assay (BA) after immunization of human volunteers with the Norwegian serogroup B meningococcal outer membrane vesicle vaccine are surveyed. In the phase II trials with adults we found very high seroconversion rates (greater than 98%) against the vaccine strain in the BA. Details in the antigenic composition of the inoculum used in the BA seem very important as shown here by finding lower bactericidal titres with teenager sera when tested with a variant of the standard inoculum. The present preliminary report corresponds to the presentation given at the Report Meeting on the Norwegian Meningococcal Vaccine Trial, Oslo, 12 September, 1991.
A P-N-P Triode Alloy-Junction Transistor for Radio-Frequency Amplification (1954)

The performance of alloy-junction transistors falls off as the frequency increases. Heretofore, the chief cause of this has been the resistance-capacitance low-pass filter effect in the base-emitter input. The effect is produced by the germanium resistance (between the external base connection and the active junction region) and the emitter-to-base diffusion capacitance. The latter may be extraordinarily high because of the relatively slow diffusion of charge carriers into the base region which must be charged up and discharged with minority carriers. In the new transistor design of the present paper, resistance and capacitance have been reduced by using a thick wafer of low-resistance germanium and placing the active junctions on a very thin section produced by drilling a well into the wafer. The junctions are about 0.0005 inch apart. Other capacitances are reduced by using small diameter junctions. To prevent limitation due to transit-time dispersion, nearly planar junctions are obtained by using germanm-indium alloy discs from which the junctions are formed. The new unit will give 39-db gain (neutralized) at 455 kc, 12 db (unneutralized) at 10 mc and has an oscillation limit of 75 mc. A noise factor at 1 mc as low as 4 db is achieved.
The Influence of ZnNb <sub>2</sub> O <sub>6</sub> on the Microwave Dielectric Properties of ZrTi <sub>2</sub> O <sub>6</sub> Ceramics (2005)

Ceramics in the system (1− x )ZrTi 2 O 6 – x ZnNb 2 O 6 (for 0.1≤ x ≤0.85) have been prepared by the mixed oxide route; specimens fired in oxygen at 1260°–1300°C achieved 97% theoretical density for most compositions. X‐ray diffraction analysis confirmed the co‐existence of a disordered α‐PbO 2 ‐type structured phase and a rutile‐structured second phase for 0.1≤ x ≤0.25, a single phase having a disordered α‐PbO 2 ‐type structure for 0.3≤ x ≤0.7, and a columbite‐type structured phase for x ≥0.85. Wavelength dispersive spectroscopy (WDS) revealed that the TiO 2 ‐rich second phase contained significant amounts of ZrO 2 , Nb 2 O 5 , and ZnO. In the two‐phase region relative permittivities (ɛ r ) are predominantly in the range 39–47 (with a peak at x =0.24), quality factor ( Q × f ) values peak at 34 000 GHz, and temperature coefficient of resonant frequency (τ f ) decreases with increase in ZnNb 2 O 6 content and tune through zero at x =0.24. In the single‐phase α‐PbO 2 region ɛ r decreases, Q × f increases to 49 000 GHz and τ f decreases to −58 ppm/°C with increasing ZnNb 2 O 6 . In the ordered columbite structure region ( x ≥0.85) the ɛ r falls to 28, Q × f increases to 59 000 GHz and τ f is more positive (−20 ppm/°C). Ceramics with x =0.24 exhibited an excellent combination of properties: ɛ r =47, Q × f =34 000 GHz, and τ f ∼0 ppm/°C.
OPTICAL FIBERS FOR COMMUNICATIONS (1977)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text TINGYE LI, "OPTICAL FIBERS FOR COMMUNICATIONS," Optics News 3(2), 10-15 (1977) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Double-multiplexed computer-generated holograms (1996)

One of the detour-phase computer-generated-hologram encoding methods was improved for obtaining two objects simultaneously without increasing the plotter resolution. The encoded patterns were reconstructed along two orthogonal diffraction directions. Such a hologram could be useful for two-channel coherent or incoherent optical correlation. Laboratory experiments demonstrate the suggested technique.
Secure Data Linkage and Information Sharing with GRHANITE (2008)

Objectives: To address and simplify the operational, ethics, consent and governance processes during the secure collection of individual identifiers and the accurate, reliable and confidential identification and re-identification of individuals to facilitate safety and quality of health care as well as accurate and rigorous evaluation research. Background: Linking accurate personal information to decision support systems can improve professional services e.g. health care or financial management. Linking professions will promote integrated services, avoiding costly duplication of infrastructure and services. However, where person-specific information is held, there are risks of identity theft or confidentiality breaches. The ethics and governance processes involved in routinely collecting data for service provision, research, evaluation, quality assurance, policy development and governance reporting need to be integrated yet simplified. Methods: Functional specifications for ethical, secure and accurate information sharing and management were established. A flexible decentralised design methodology was adopted to develop GRHANITE [TM] to manage informed consent, encrypt, extract, link and manipulate personal clinical data without collecting or exposing personal identifiers. Results: GRHANITE [TM] reduces risks of confidentiality breaches and identity theft by dispensing with the need to collect and store recognisable person identifiers and by forcing informed consent processes. GRHANITE [TM] has interfaced with disparate technologies in a generic manner to: (1) demonstrate the secure, de-identified linkage processes enable accurate and reliable identification; (2) de-identification mechanisms with security protocols can effectively guarantee privacy in the collection, linkage, aggregation and analysis system; and (3) Secure re-identification of individuals is still possible in source systems. Large-scale de-identified data repositories which hold no identifiable person-identifiers BUT are able to perform automated data linkage and acquisition can be developed and maintained in a viable manner. Implications: The GRHANITE [TM] research and development program will provide the knowledge to underpin the next generation of encrypted data repositories and their implementation in service organisations, delivering innovations in personal identification, information protection and integrity of national security systems.
Oleamide: A Fatty Acid Amide Signaling Molecule in the Cardiovascular System? (2007)

Oleamide (cis-9,10-octadecenoamide), a fatty acid primary amide discovered in the cerebrospinal fluid of sleep-deprived cats, has a variety of actions that give it potential as a signaling molecule, although these actions have not been extensively investigated in the cardiovascular system. The synthetic pathway probably involves synthesis of oleoylglycine and then conversion to oleamide by peptidylglycine alpha-amidating monooxygenase (PAM); breakdown of oleamide is by fatty acid amide hydrolase (FAAH). Oleamide interacts with voltage-gated Na(+) channels and allosterically with GABA(A) and 5-HT(7) receptors as well as having cannabinoid-like actions. The latter have been suggested to be due to potentiation of the effects of endocannabinoids such as anandamide by inhibiting FAAH-mediated hydrolysis. This might underlie an "entourage effect" whereby co-released endogenous nonagonist congeners of endocannabinoids protect the active molecule from hydrolysis by FAAH. However, oleamide has direct agonist actions at CB(1) cannabinoid receptors and also activates the TRPV1 vanilloid receptor. Other actions include inhibition of gap-junctional communication, and this might give oleamide a role in myocardial development. Many of these actions are absent from the trans isomer of 9,10-octadecenoamide. One of the most potent actions of oleamide is vasodilation. In rat small mesenteric artery the response does not involve CB(1) cannabinoid receptors but another pertussis toxin-sensitive, G protein-coupled receptor, as yet unidentified. This receptor is sensitive to rimonabant and O-1918, an antagonist at the putative "abnormal-cannabidiol" or endothelial "anandamide" receptors. Vasodilation is mediated by endothelium-derived nitric oxide, endothelium-dependent hyperpolarization, and also through activation of TRPV1 receptors. A physiological role for oleamide in the heart and circulation has yet to be demonstrated, as has production by cells of the cardiovascular system, but this molecule has a range of actions that could give it considerable modulatory power.
A Bi-Directional Gas Thrust Bearing (1991)

A gas bearing with a bi-directional hydrodynamic geometry is presented and analyzed. The configuration considered is an equally spaced set of alternating land and radial groove sectors, together forming a bearing surface. The typical operating gap of the bearing is very small and a predominant laminar viscous flow field is assumed. The Reynolds equation is therefore used to describe the flow field. A parametric study of the controlling equations shows that four dimensionless geometric parameters in conjunction with the bearing number fully define the problem. A simplified one-dimensional and a more complete two-dimensional steady-state analyses are performed to optimize the governing parameters for maximum load carrying capacity and maximum film stiffness. This study shows that the performance prediction capability of the one-dimensional model is overly conservative and not satisfactory, but that its parametric optima are in favorable agreement with the two-dimensional analysis results. The load carrying capacity of the bi-directional bearing is shown to be comparable to that of a Rayleigh step or plain slider bearing. This design offers the great advantage of independence of direction of shaft rotation.
NovelJARID1C/SMCX mutations in patients with X-linked mental retardation (2006)

X-linked mental retardation (XLMR) is a heterogeneous disorder that affects approximately 2 in 1000 males. JARID1C/SMCX is relatively new among the known XLMR genes, and seven different mutations have been identified previously in this gene [Jensen LR et al., Am. J. Hum. Genet. 76:227-236, 2005]. Here, we report five novel JARID1C mutations in five XLMR families. The changes comprise one nonsense mutation (p.Arg332X) and four missense mutations (p.Asp87Gly; p.Phe642Leu; p.Arg750Trp; p.Tyr751Cys) affecting evolutionarily conserved amino acids. The degree of mental retardation in the affected males ranged from mild to severe, and some patients suffered from additional disorders such as epilepsy, short stature, or behavioral problems. This study brings the total number of reported JARID1C mutations to twelve. In contrast to other XLMR genes in which mutations were found only in single or very few families, JARID1C appears to be one of the more frequently mutated genes in this disorder.
Whole-Genome Comparison Reveals Novel Genetic Elements That Characterize the Genome of Industrial Strains of Saccharomyces cerevisiae (2011)

Human intervention has subjected the yeast Saccharomyces cerevisiae to multiple rounds of independent domestication and thousands of generations of artificial selection. As a result, this species comprises a genetically diverse collection of natural isolates as well as domesticated strains that are used in specific industrial applications. However the scope of genetic diversity that was captured during the domesticated evolution of the industrial representatives of this important organism remains to be determined. To begin to address this, we have produced whole-genome assemblies of six commercial strains of S. cerevisiae (four wine and two brewing strains). These represent the first genome assemblies produced from S. cerevisiae strains in their industrially-used forms and the first high-quality assemblies for S. cerevisiae strains used in brewing. By comparing these sequences to six existing high-coverage S. cerevisiae genome assemblies, clear signatures were found that defined each industrial class of yeast. This genetic variation was comprised of both single nucleotide polymorphisms and large-scale insertions and deletions, with the latter often being associated with ORF heterogeneity between strains. This included the discovery of more than twenty probable genes that had not been identified previously in the S. cerevisiae genome. Comparison of this large number of S. cerevisiae strains also enabled the characterization of a cluster of five ORFs that have integrated into the genomes of the wine and bioethanol strains on multiple occasions and at diverse genomic locations via what appears to involve the resolution of a circular DNA intermediate. This work suggests that, despite the scrutiny that has been directed at the yeast genome, there remains a significant reservoir of ORFs and novel modes of genetic transmission that may have significant phenotypic impact in this important model and industrial species.
FORTRAN 77 and numerical methods for engineers (1985)

This text introduces the beginner to FORTRAN. To help the reader develop analysis skills while learning programming, engineering computations are incorporated with sound programming practices. Eight major programming assignments sections, each with a sample and solved model, illustrate the methods of preceding chapters, as well as introduce discussions concerning engineering orientation. This second edition integrates numerous advanced topics in numerical methods as they relate to computational procedures in order to reinforce their application in other courses such as calculus and physics. Topics especially tailored to the beginning user include matrix equations, root of functions, curve-fitting, series expansions, integration and differentiation and differential equations.
Major Contribution of the P2Y <sub>1</sub> Receptor in Purinergic Regulation of TNFα-Induced Vascular Inflammation (2011)

The data highlight a key role of the endothelial P2Y(1) receptor in acute vascular inflammation. Pharmacological targeting the P2Y(1) receptor could represent a promising approach for the treatment of vascular inflammation.
Transient Micromotors That Disappear When No Longer Needed (2016)

Transient self-destroyed micromotors that autonomously disappear in biological media at controlled rates upon completing their task, without leaving a toxic residue, are presented. The propulsion and degradation characteristics of the self-destroyed Mg/ZnO, Mg/Si, and Zn/Fe Janus micromotors and single-component Zn micromotors are described. The degradation of the Janus micromotors relies on the different corrosion rates of their core-shell components. Inductively coupled plasma optical emission spectrometry measurements are used to probe the time-dependent degradation of the different constituents of the micromotors. The toxicity of the transient micromotors is discussed toward their potential use in biomedical applications. This concept of transient micromotors offers considerable potential for diverse practical applications in the near future.
Chemotherapy for patients with non-small cell lung cancer: the surgical setting of the Big Lung Trial1 (2004)

This trial has failed to observe a survival benefit with adjuvant chemotherapy following complete resection of stage I-III NSCLC. However, the hazard ratio and 95% confidence intervals are consistent with the previously reported meta-analysis and two large recently reported trials, which suggest a small survival benefit with cisplatin-based chemotherapy.