gebhart/patrepeval huggingface dataset:
Case Report: Spectral Overlap Artifact During Dual Isotope Imaging with Tc-99m and In-111 (1984)

Case Report: A fifty-year-old male was referred to nuclear medicine for liver-spleen imaging in order to rule out hepatic abscess following abdominal surgery. Five mCi Tc-99m sulfur colloid was administered and 500k count images were obtained using a large field-of-view scintillation camera with a low energy high resolution collimator. One lesion was seen on the anterior image (Fig. lA) and two lesions on the right lateral image. An In-Ill leukocyte study (2 ,3) was then requested to confirm hepatic abscess. Imaging was performed twenty-four hours after intravenous administration of0.5 mCi In-llllabeled autologous leukocytes. A large field-of-view gamma camera with a medium energy parallel hole collimator was used to acquire 500k count (or 10 minute) images (Fig. 1B) from two 20% windows centered around the 173 and 247 keY In-111 photopeaks. A Tc-99m sulfur colloid image subtraction technique was then performed using 2 mCi ofTc-99m sulfur colloid to subtract liver tissue from the ln-111 image (1). Upon reviewing the In-111 and 2 mCi Tc-99m subtraction images, the nuclear medicine physician then requested an additional In-111 image in the right anterior oblique position (Fig. 1C). The In-111 image contained discrete hot spots resem-
Prototyping PHLOX, a high performance transaction processing system on a workstation cluster with shared disks (2002)

Coupling multiple workstations for high performance transaction processing has become increasingly attractive for reasons of capacity, cost, and availability. PHLOX is a prototypical transaction processing system running on the workstation cluster with shared disks. PHLOX supports a message oriented file system for database sharing, global cache coherency and concurrency control, affinity-based transaction routing, and sophisticated database recovery protocol. The paper describes the current prototype of PHLOX and discusses some of the major design decisions that went into its construction. The lessons learned from this prototype and its predecessors are also presented.
Diastereoselective Synthesis of <i>S</i>-<i>tert</i>-Butyl-β-(trifluoromethyl)isocysteine (2002)

Both diastereoisomers of S-tert-butyl-beta-(trifluoromethyl)isocysteine have been synthesized stereoselectively by the sequential reactions of trifluoroacetimidoyl chloride with the lithium enolate of tert-butyl alpha-tert-butylthioacetate, followed by the diastereoselective reduction of the imino group with sodium borohydride in the presence of zinc(II) or di(ethylene glycol) dimethyl ether, and finally by the deprotection of N-aryl and tert-butyl ester groups.
Lassa Fever, a New Virus Disease of Man from West Africa (1970)

Lassa Fever, a hitherto unknown virus disease from Nigeria, caused the death of two missionary-nurses and the grave illness of a third. The onset is gradual with fever, weakness, myositis and ulcerative pharyngitis, progressing to symptoms of myocarditis, pneumonitis and pleuritis, encephalopathy, and evidences of a hemorrhagic diathesis. It is characterized in the early stages by moderate leukopenia, with increase of immature neutrophilic elements. It may be transmitted directly from person to person; the incubation period is about a week. It is likely to be of increasing public-health importance as travel to the interior parts of Nigeria increases, and as the area is developed because of future population pressures.
Theme and Motif in La Guerre de Troie n’aura pas lieu (1959)

Flaubert once said that a theme imposes itself upon the writer, that it demands to be treated. And Curtius remarked that the choice of a theme reflects an author’s basic attitude toward the world, that it indicates his typical reactions to given situations. But he also pointed out that he who has only a theme will not necessarily create great literature. No doubt, the theme alone cannot assure literary value to any work; nor does the particular orientation, the point of view from which the theme is treated, endow the work with stature. Broadly considered, war is the theme of La Guerre de Troie n’aura pas lieu, and a despondent pacifism is its orientation. At first glance, the play appears to say either that war is in the hearts of men or that it is a pastime of gods indifferent to human will or human prayers.
Enzymatic properties of the beta-galactoside alpha 1 leads to 2 fucosyltransferase from porcine submaxillary gland. (1980)

The acceptor substrate specificity and kinetic properties of the purified porcine submaxillary beta-galactoside alpha 1 leads to 2 fucosyltransferase have been examined. The transferase forms the Fuc alpha 1 leads to 2Gal linkage with oligosaccharides, glycoproteins, and glycolipids which contain nonreducing terminal galactose residues and shows no absolute specificity for a particular penultimate residue or for the linkage between the galactose and the penultimate residue. The fucosyltransferase is active in the absence of divalent metal ions, but it is stimulated upon addition of Mn2+, Mg2+, Ca2+, or Co2+. Kinetic analysis indicates an increase in the Km for both donor and acceptor substrates and in the Vmax in the presence of Mn2+. Initial rate studies and inhibition patterns suggest that the transferase has either a rapid equilibrium random kinetic mechanism or a steady state ordered mechanism with GDP-fucose binding first. Human "Bombay" erythrocytes which lack cell surface Fuc alpha 1 leads to 2Gal structures are fucosylated by the transferase, but expression of H blood group activity is dependent on treatment of the cells with neuraminidase. After neuraminidase digestion, the fucosylated cells are serologically identical to native O-type cells. Analysis of the fucosylated material in the erythrocyte membrane on sodium dodecyl sulfate-polyacrylamide gel electrophoresis suggests that fucose is incorporated primarily into glycoprotein acceptors.
Investigation of poly(arylene vinylene)s, 41. Synthesis of soluble dialkoxy-substituted poly(phenylene alkenylidene)s by applying the Horner-reaction for condensation polymerization (1999)

Soluble poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene-1,2-ethenylene] (MEH-PPV) and its alternating copolymer poly[2,5-dimethoxy-1,4-phenylene-1,2-ethenylene-2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene-1,2-ethenylene] (M3EH-PPV) were successfully synthesized by condensation polymerization of substituted terephthalaldehydes with substituted xylylene bisphosphonates via the Horner reaction. This polycondensation method was also applied to the synthesis of the analogous poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylene-1,3-butadiene-1,4-diyl] (MEH-PPB), which contains a 1,3-butadiene instead of a vinylene unit. The optical data of MEH-PPV and M3EH-PPV (solid film, abs. λmax 484 nm, em. λmax 589 nm) are consistent with those previously reported for MEH-PPV from the dehydrohalogenation route. In comparison to MEH-PPV, the longer alkenylene sequence of MEH-PPB exhibits a slight red shift in its absorption and fluorescence spectra (abs. λmax 502 nm, em. λmax 604 nm). All three polyphenylene alkenylidenes (MEH-PPV, M3EH-PPV, and MEH-PPB) are completely soluble in common solvents. They are well-defined conjugated polymers of high molecular weight (Mw > 20 000) and possess all-trans structure. Optical quality solid films are easily prepared from these polymers by solution processing. Blends with phenyl-substituted PPV derivatives can also be prepared in this way. This combination of properties is highly desirable for many light-emitting, nonlinear optical, and photoelectrical applications.
Volume probes: interactive data exploration on arbitrary grids (1990)

A taxonomy of computational grids used in scientific and engineering practice is presented and a technique for cutting them by, and displaying data on, 2D surfaces is developed. When sliced by a surface, these grids give rise to a graph G(C, F) where C, the nodes, are the intersected cells and F, the arcs, are their connectivity across faces. Starting from any cell known to be intersected by the surface (a seed), G is traversed breadth-first and is constructed locally on the fly, that is, only the spreading "front" explicitly exists at any time. Only sliced cells are visited, shared computed values such as edge intersections are passed to neighbors, and most of the geometric work is done via table lookup. A seed cell is found by fence-hopping from any cell to a distinguished point on the surface.This means of slicing grids is then utilized in an effective visualization tool. Concentrating on planar surfaces, local coordinate systems are defined for constructing clipping windows and linear transformations within the planes which further reduces display time and allows effects such as zooming within the windows. Several of these planar windows are then organized into various objects, called probes, that can exploit the mind's "retinal memory" when repeatedly swept through amorphous data.
The Seed-Specific Transcription Factor VP1 (OSVP1) Is Expressed in Rice Suspension-Cultured Cells (1996)

A seed-specific transcriptional regulator, VP1, is required for the induction of ABA-regulated genes that include Lea (late embryogenesis abundant protein) genes. Although the induction of one rice Lea gene, Osem, by ABA is normally restricted to seed tissues, we found that the expression was strongly induced by ABA in the Oc line of rice suspension-cultured cells. Since this observation suggested that rice VP1 (OSVP1) protein or a functionally similar protein might be expressed in the cultured cells, we analyzed the expression of Osvp1 in these cells at both the mRNA and the protein level, we detected Osvp1 mRNA and OSVP1 protein in the cultured cells at levels similar to or higher than those in developing embryos. In the cultured cells, neither the level of total cellular OSVP1 nor that of nuclear OSVP1 protein was affected by ABA. Based on the results, the mechanism for the transcriptional regulation of VP1-dependent ABA-inducible genes is discussed.
A critical review of reports of endogenous psychedelic N, N‐dimethyltryptamines in humans: 1955–2010 (2012)

Three indole alkaloids that possess differing degrees of psychotropic/psychedelic activity have been reported as endogenous substances in humans; N,N-dimethyltryptamine (DMT), 5-hydroxy-DMT (bufotenine, HDMT), and 5-methoxy-DMT (MDMT). We have undertaken a critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids. In reviewing this literature, we address the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT. The review provides a historical perspective of the research conducted from 1955 to 2010, summarizing the findings for the individual compounds in blood, urine, and/or cerebrospinal fluid. A critique of the data is offered that addresses the strengths and weaknesses of the methods and approaches to date. The review also discusses the shortcomings of the existing data in light of more recent findings and how these may be overcome. Suggestions for the future directions of endogenous psychedelics research are offered.
A modular architecture for real time HDTV motion estimation with large search range (2002)

A modular architecture with random access on-chip local memory for real-time motion estimation has been proposed. The random access on-chip local memory with simple address generation has been proposed to overcome the irregular data flow of the three-step search BMA. This architecture features simple interconnection with low memory bandwidth and throughput rate as high as 1/N block per clock cycle for an N/spl times/N block with the search range of d/sub m/=N/2-1 pixels with 100% processor utilization. By using a method called pipeline interleaving, this architecture offers a feasible solution for the Grand Alliance HDTV picture format with large search range.
Increased Phase Synchronization between Intracranial Pressure and Arterial Blood Pressure during Elevated Intracranial Pressure in Dogs (2005)

We applied the concept of "phase synchronization" from nonlinear dynamics to the complex relationship between intracranial pressure (ICP) and arterial blood pressure (ABP) signals. This method is based on multiresolution wavelet transform (MRWT) in which the signals are divided into different frequency bands. We examined ICP and ABP signals from anaesthetized dogs, exploring normal ICP and elevated ICP by 1~3 ml injection of saline into the cerebral ventricles. Phase synchronization analyses show an interesting phenomenon of phase reset from relatively uniform phase distribution to phase clustering around 0° after injection. To further quantitatively measure phase synchronization, phase coherence is used to distinguish the dynamics of normal ICP and elevated ICP by saline injection. Elevated ICP exhibits higher phase coherence than that of normal ICP. The results suggest that the association between ICP and ABP may involve nonlinear mechanisms of regulation. The clinical application of this method is in investigation.
A 4OMHz programmable semi-systolic transversal fitter (1987)

This paper will report on a transversal filter architecture with programmable coefficients. A test chip of a 7 tap fitter with 10b data, 8b coefficients and a 40MHz sampling rate has been realized. The 38.5K transistors with a total chip area of 14.6mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> in a 1.5μ CMOS technology achieve a functional throughput rate-per chip area of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4×10^{12}</tex> Hz times gates per cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Label-Free Sensing of Binding to Microarrays Using Brewster Angle Straddle Interferometry (2007)

We report an interferometric method to detect chemical binding at an interface. The interference layer consists of the thin native oxide on silicon, and we utilize nearly opposite phase shifts of light at the oxide/water and oxide/silicon interfaces to achieve near-complete destructive interference. We measure selective binding of thrombin in solution to DNA aptamers covalently bound to the oxide. The technique can be used to detect and quantify surface binding of less than 1 A of material, sensitivity similar to that of surface plasmon resonance imaging or arrayed imaging reflectometry. Results are in quantitative agreement with what is predicted theoretically. The method is very convenient to implement since it utilizes unmodified silicon wafers as substrates and is extremely insensitive to both probe light bandwidth and collimation.
Effect of vortex generators on the power conversion performance and structural dynamic loads of the Mod-2 wind turbine (1984)

Applying vortex generators from 20 to 100 percent span of the Mod-2 rotor resulted in a projected increase in annual energy capture of 20 percent and reduced the wind speed at which rated power is reached by nearly 3 m/sec. Application of vortex generators from 20 to 70 percent span, the fixed portion of the Mod-2 rotor, resulted in a projected increase in annual energy capture of about half this. This improved performance came at the cost of a small increase in cyclic blade loads in below rated power conditions. Cyclic blade loads were found to correlate well with the change in wind speed during one rotor revolution.
BOTS (2006)

Embedded application developers create applications for a wide range of devices with different resource constraints. Developers want to maximize the use of the limited resources available on the device while still not exceeding the capabilities of the device. To do this, the developer must be able to scale his software for different platforms. In this paper, we present a software engineering methodology that automatically scales software to different platforms. We intend to have the application developer write high level functional specifications of his software and have tools that automatically scale the underlying runtime. These tools will use the functional and non-functional constraints of both the hardware and client application to produce an appropriate runtime. Our initial results show that the proposed approach can scale operating systems and virtual machines that satisfy the constraints of varying hardware/application combinations.
Photoreceptor Dysplasia: An Inherited Progressive Retinal Atrophy of Miniature Schnauzer Dogs (1991)

A progressive retinal atrophy (PRA) affecting Miniature Schnauzer dogs is reported. Of the 287 individuals (148 female, 139 male) comprising the study population, 66 (23 percent) were affected (33 female, 33 male) and 221 animals (115 female, 106 male) were phenotypically normal. There was no sex predilection for the disease. Results of histologic and electroretinographic studies indicate that the disease is a new and different type of PRA, characterized by unique morphologic and functional deficits during rod and cone development. Accordingly, the disease has been termed photoreceptor dysplasia. Clinically, and particularly ophthalmoscopically, diagnosis is only practicable in very late stages of the disease. Electroretinography, however, can provide evidence of the disease in dogs at least as young as 8 weeks of age. Pedigree analysis and test-mating studies conclusively establish that inheritance is autosomal recessive. The gene symbol pd (for photoreceptor dysplasia) is assigned.
Novel Insights into the Molecular Mechanisms of Human Thyrotropin Action: Structural, Physiological, and Therapeutic Implications for the Glycoprotein Hormone Family (1997)

I. Introduction A. Historical background B. TSH and the glycoprotein hormone family II. Structure-Function Relationships of TSH in Relation to Studies on Gonadotropins A. Methodological considerations B. Structure-function studies of protein domains C. Structure-function studies of carbohydrate chains III. Current Understanding of TSH/Glycoprotein Hormone Action A. Structural considerations B. Hormone-receptor interaction C. Cooperation of individual hTSH domains in receptor activation IV. Physiological and Pathophysiological Implications A. Carbohydrate heterogeneity B. Naturally occurring glycoprotein hormone mutations C. “Specificity spillover” syndromes V. Evolutionary Considerations A. Glycoprotein hormone specificity B. Evolutionary changes in TSH activity VI. Strategies in the Design of Novel TSH Analogs and Therapeutic Implications A. Clinical use of rhTSH B. Design of novel glycoprotein hormone analogs VII. Nonclassic Actions of TSH and Gonadotropins A. Extrathyroidal/extragonadal glycoprotein ho...
Assistência de enfermagem ao paciente com lesão por pressão (2020)

Introdução: Os fatores decorrentes da Lesão por Pressão (LPP), tais como a dor e o impacto emocional são fatores estressantes para o paciente, os mesmos são ocasionados a uma interrupção do fluxo sanguíneo em uma determinada área, generalizando uma deficiência no fluxo sanguíneo. Objetivos: Descrever a importância da atuação da equipe de enfermagem nas LPP. Metodologia: Trata-se de um estudo tipo revisão de literatura, no qual foram utilizadas as seguintes bases de dados: LILACS, SCIELO, PUB MED, BIREME e MS, com os seguintes descritores, tratamentos, cuidados e prevenções.Os critérios de inclusão foram artigos publicados no período de 2014 a 2018, textos completos. Já os de exclusão foram artigos de caráter comercial, publicados há mais de 5 anos. Foram encontrados 12 trabalhos. Destes, dois foram selecionados por se enquadrarem nos critérios de elegibilidade. Resultados e Discussão: As LPP são um problema comum em pacientes acamados e em uso prolongado de cadeira de rodas, acometendo principalmente as regiões de proeminências ósseas. O uso escala de Braden contribui para identificar com mais rapidez e asserção os fatores de risco, proporcionando um melhor prognóstico. É importante que a equipe de enfermagem realize a mudança de decúbito, a fim de prevenir as LPP.Considerações Finais: As práticas assistenciais de enfermagem, reduzem significativamente as LPP, sendo tratadas através da prevenção de riscos sistematizados e tratamento curativo.
Engineered 3D environments to elucidate the effect of environmental parameters on drug response in cancer (2010)

Traditional in vitro models used for the development of anti-cancer drugs are based on the monolayer culture of cells, which has a limited predictivity of in vivo efficacy. A number of cell culture platforms have been developed in recent years to improve predictivity and further to elucidate the mechanisms governing the differing responses observed in vitro versus in vivo. One detrimental aspect of current in vitro models is their inability to decouple the effect of different extrinsic factors on the responsiveness of the cells to drug treatment. Here, we have used an engineered poly(dimethylsiloxane) (PDMS) microwell array as a reductionist approach to study the effect of environmental parameters, independently of each other. It is observed for MCF-7 breast cancer cells, that culture within the three-dimensional (3D) environment of the microwells alone had an effect on the response to Taxol and results in a reduction of cell death in comparison to cells cultured on flat substrates. Additionally the microwells allowed the response of single versus multicell clusters to be differentiated. It was found that the formation of cell-cell contacts alters the drug response, depending on the type of adhesive protein present. Thus, with this microwell platform it is revealed that the presence of cell-cell contacts in addition to the dimensionality and the matrix composition of the environment are important mediators of altered drug responses. In conclusion the microwell array can not only serve as a platform to reveal which parameters of the extracellular environment affect drug response but further the interdependence of these parameters.
Patents: (1991)

Patents are invaluable sources of technological information, of importance not only to inventors, but also to the processes of economic development and technology transfer. Researching patents is an excellent means of tracking a business competitor, forecasting technological innovation, learning how to make and use a device or process, and finding answers to specific technical problems. Nevertheless, patents are under-used as sources of technical information. Many libraries, including the libraries of Penn State University, have established outreach programs to overcome that low use. Through the provision of such programs, libraries have the potential to be key players in the development of closer ties among universities, industries, and individual entrepreneurs. Locating patent information may not be an easy task, but it is not as complicated as many think. The development of computerized information systems has simplified the search process. Reference librarians, even non-documents librarians, can be of enormous assistance in leading researchers to patent information. However, they must be even more aware than usual of the need for confidentiality, when providing patent reference service.