gebhart/patrepeval huggingface dataset:
A Wide-Tracking Range Clock and Data Recovery Circuit (2008)

A hybrid analog-digital quarter-rate clock and data recovery circuit (CDR) that achieves a wide-tracking range and excellent frequency and phase tracking resolution is presented in this paper. A split-tuned analog phase-locked loop (PLL) provides eight equally spaced phases needed for quarter-rate data recovery and the digital CDR loop adjusts the phase of the PLL output clocks in a precise manner to facilitate plesiochronous clocking. The CDR employs a second-order digital loop filter and combines delta-sigma modulation with the analog PLL to achieve sub-picosecond phase resolution and better than 2 ppm frequency resolution. A test chip fabricated in a 0.18 mum CMOS process achieves BER <10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> and consumes 14 mW power while operating at 2 Gb/s. The tracking range is greater than plusmn5000 ppm and plusmn2500 ppm at 10 kHz and 20 kHz modulation frequencies, respectively, making this CDR suitable for systems employing spread-spectrum clocking.
Editorial: The Listening of Talking and Listening (1973)

(1973). Editorial: The Listening of Talking and Listening. Transactional Analysis Journal: Vol. 3, No. 2, pp. 10-10.
Exploring<i>Immigrant</i>: (1988)

No abstract available for this article.
MEK inhibitors for the treatment of non-small cell lung cancer (2021)

BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAPK signaling pathway. Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell lung cancer (NSCLC). They lead to the proliferation, differentiation, and apoptosis of tumor cells by activating the RAS/RAF/MEK/ERK signaling pathway. To date, agents that target RAS/RAF/MEK/ERK signaling pathway have been investigated in NSCLC patients harboring BRAF mutations. BRAF and MEK inhibitors have gained approval for the treatment of patients with NSCLC. According to the reported findings, the combination of MEK inhibitors with chemotherapy, immune checkpoint inhibitors, epidermal growth factor receptor-tyrosine kinase inhibitors or BRAF inhibitors is highly significant for improving clinical efficacy and causing delay in the occurrence of drug resistance. This review summarized the existing experimental results and presented ongoing clinical studies as well. However, further researches need to be conducted to indicate how we can combine other drugs with MEK inhibitors to significantly increase therapeutic effects on patients with lung cancer.
The use and nutritional value of Artemia as a food source (1986)

Liste des especes testees avec les resultats obtenus. Differentes techniques d'enrichissement utilisees (anglaise, japonaise, francaise, belge). Valeur nutritive, composition chimique et biometrie d'Artemia
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice (2016)

Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in vitro studies of power generation by mutant and wild-type sarcomere proteins are consistent with mutant sarcomeres exhibiting enhanced contractile power, others are not. We identified a small molecule, MYK-461, that reduces contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain. Here we demonstrate that early, chronic administration of MYK-461 suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain. These data indicate that hyperdynamic contraction is essential for HCM pathobiology and that inhibitors of sarcomere contraction may be a valuable therapeutic approach for HCM.
TGF-β1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors (2000)

We examined the effect of TGF-beta 1 on the chemotactic migratory ability of human monocyte-derived dendritic cells (DCs). Treatment of immature DCs with TGF-beta 1 resulted in increased expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXC chemokine receptor-4 (CXCR-4), which were concomitant with enhanced chemotactic migratory responses to their ligands, RANTES (for CCR-1, CCR-3, and CCR-5), macrophage-inflammatory protein-3 alpha (MIP-3 alpha) (for CCR-6), or stromal cell-derived growth factor-1 alpha (for CXCR-4). Ligation by TNF-alpha resulted in down-modulation of cell surface expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4, and the chemotaxis for RANTES, MIP-3 alpha, and stromal cell-derived growth factor-1 alpha, whereas this stimulation up-regulated the expression of CCR-7 and the chemotactic ability for MIP-3beta. Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha-induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha-induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta. Our findings suggest that TGF-beta 1 reversibly regulates chemotaxis of DCs via regulation of chemokine receptor expression.
Nutritional and Antigenic Characterization of an Enzymic Whey Protein Hydrolyzate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNutritional and Antigenic Characterization of an Enzymic Whey Protein HydrolyzateJulio J. Boza, Olga Martinez-Augustin, and Angel GilCite this: J. Agric. Food Chem. 1995, 43, 4, 872–875Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/jf00052a005https://doi.org/10.1021/jf00052a005research-articleACS PublicationsRequest reuse permissionsArticle Views210Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ni(111)<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mo>|</mml:mo></mml:math>graphene<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mo>|</mml:mo><mml:mi>h</mml:mi></mml:mrow></mml:math>-BN junctions as ideal spin injectors (2011)

Deposition of graphene on top of hexagonal boron nitride ($h$-BN) was very recently demonstrated, while graphene is now routinely grown on Ni. Because the in-plane lattice constants of graphite, $h$-BN, graphitelike BC${}_{2}$N, and of the close-packed surfaces of Co, Ni, and Cu match almost perfectly, it should be possible to prepare ideal interfaces between these materials which are, respectively, a semimetal, an insulator, a semiconductor, and ferromagnetic and nonmagnetic metals. Using parameter-free energy minimization and electronic transport calculations, we show how $h$-BN can be combined with the perfect spin filtering property of Ni$|$graphite and Co$|$graphite interfaces to make perfect tunnel junctions or ideal spin injectors with any desired resistance-area product.
Non-Conformity and the British Labour Movement: A Case Study (1975)

Journal Article Non-Conformity and the British Labour Movement: A Case Study Get access Kenneth D. Brown Kenneth D. Brown Queen's University, Belfast Search for other works by this author on: Oxford Academic Google Scholar Journal of Social History, Volume 8, Issue 2, Winter 1975, Pages 113–120, https://doi.org/10.1353/jsh/8.2.113 Published: 01 January 1975
No es la sentencia “Miranda”, la del Tribunal Constitucional 21/2018, de 5 de marzo (2018)

La STC (Secc.1.a) de 5 de marzo de 2018 incide en los derechos de los detenidos a ser informados de las razones de la detencion y de acceso a elementos de las actuaciones. La informacion ha de ser suficiente y suministrada al detenido por escrito mediante un documento que debe ser puesto a disposicion antes de su primer interrogatorio por parte de la policia en el que se exprese el fundamento de la conexion subjetiva y objetiva del detenido con el hecho ilicito que justifica la detencion. El acceso debe producirse de forma efectiva, mediante exhibicion, entrega de copia o cualquier otro metodo que, garantizando la integridad de las actuaciones, permita al detenido conocer y comprobar por si, o a traves de su letrado, las bases objetivas de su privacion de libertad.
Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE−/− mice (2010)

AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms) through multiple proposed mechanisms, including chemotaxis. Therefore, we determined the effects of whole-body deficiency of the chemokine receptor CCR2 (CC chemokine receptor 2) on these diseases. To meet this objective, apoE (apolipoprotein E)-/- mice that were either CCR2+/+ or CCR2-/-, were infused with either saline or AngII (1000 ng.kg-1 of body weight.min-1) for 28 days via mini-osmotic pumps. Deficiency of CCR2 markedly attenuated both atherosclerosis and AAAs, unrelated to systolic blood pressure or plasma cholesterol concentrations. During the course of the present study, we also observed that AngII infusion led to large dilatations that were restricted to the ascending aortic region of apoE-/- mice. The aortic media in most of the dilated area was thickened. In regions of medial thickening, distinct elastin layers were discernable. There was an expansion of the distance between elastin layers in a gradient from the intimal to the adventitial aspect of the media. This pathology differed in a circumscribed area of the anterior region of ascending aortas in which elastin breaks were focal and almost transmural. All regions of the ascending aorta of AngII-infused mice had diffuse medial macrophage accumulation. Deficiency of CCR2 greatly attenuated the AngII-induced lumen dilatation in the ascending aorta. This new model of ascending aortic aneurysms has pathology that differs markedly from AngII-induced atherosclerosis or AAAs, but all vascular pathologies were attenuated by CCR2 deficiency.
Verarbeitung von langfaserverstärkten Thermoplasten im direkten Plastifizier-, Pressverfahren (2001)

The direct strand-deposition process which is capable to process thermoplastic matrix materials in the form of powder, chopped glass-fibres and additives in a single-screw plastification unit is examined in this work. By using the material combination glass/polypropylene, the influence of the process parameters on the properties of the long-fibre reinforced press masses is characterised. In order to guarantee a fibre-friendly processing during plastification and to achieve a complete fibre debundling and a good fibre filament distribution, special attention must be paid to the right starting material and to the right machinery. Requirements are discussed. The influence of the resulting structure of reinforcement (fibre content, resulting fibre length and fibre length distribution, fibre debundling and filament distribution, fibre orientation) on the achievable mechanical properties are estimated by using simple equations. Trials are carried out to characterise the influence of the process parameters of the plastification unit on the reinforcement structure. Methods are developed to enable a precise measurement of every form of reinforcement. Mechanical properties that are determined in short-tensile and penetration testing are showing a dependency on the properties of the resulting structure of reinforcement. Measured properties of the compression moulded products are in the same range as the ones of glass-mat reinforced thermoplastics.
Improving Picture Boundary Handling for Video Coding Beyond HEVC (2018)

Block partitioning is an essential component of today's hybrid video codecs. In order to support video sequences with arbitrary spatial resolution, the HEVC standard and the JEM reference software utilize a forced quadtree (QT) method to process CTUs/CUs located at the picture boundaries. While the forced QT method is simple to implement, it is unsatisfactory from a coding efficiency perspective. To improve the compression performance, novel block partitioning methods are currently being proposed. Our approach for picture boundary handling uses a binary tree (BT) based splitting scheme to deal with the boundary located CTUs/CUs. We present two variants with the first one combining forced BT with forced QT partitioning (forced QTBT) and the second one adaptively choosing between BT and QT (adaptive QTBT). Experimental results obtained with the JEM-6.0 reference software after integrating our approaches demonstrate that our proposed methods provide an average luma BD-rate reduction of 0.85% for the forced QTBT scheme and 0.96% for the adaptive QTBT scheme when using the random access configuration.
Scrapie‐associated PrP Accumulation and Its Inhibition: Revisiting the Amyloid‐Glycosaminoglycan Connection (1994)

An abnormal protease-resistant isoform of the protein PrP accumulates in the brain of hosts with transmissible spongiform encephalopathies (TSEs) and appears to be centrally involved in TSE pathogenesis. Studies with scrapie-infected tissue culture cells have indicated that this abnormal PrP is formed from an apparently normal precursor on the plasma membrane or along an endocytic pathway to the lysosomes. Inhibitors of protease-resistant PrP accumulation might serve as tools for studying the basic mechanism of protease-resistant PrP formation and as potential drugs for TSE therapy. Using scrapie-infected neuroblastoma cells to screen for such compounds in vitro, we found that the amyloid binding dye Congo red and certain sulfated glycans potently inhibited the accumulation of protease-resistant PrP in scrapie-infected cells without apparent effects on the metabolism of the normal isoform. The relative potencies of the sulfated glycans corresponded with their previously determined anti-scrapie activities in vivo, suggesting that the prophylactic effects of sulfated polyanions may be due to inhibition of protease-resistant PrP accumulation. Since protease-resistant PrP amyloid is known to contain sulfated glycosaminoglycans, as do other naturally derived amyloids, we hypothesize that these sulfated inhibitors competitively block binding between PrP and endogenous glycosaminoglycans that is important for its accumulation in a protease-resistant, potentially amyloidogenic state. Drugs which interfere with this (pre)amyloid-glycosaminoglycan interaction may be useful for treating a variety of amyloidoses.
Determination of Ligand-Field Parameters and f-Electronic Structures of Hetero-Dinuclear Phthalocyanine Complexes with a Diamagnetic Yttrium(III) and a Paramagnetic Trivalent Lanthanide Ion (2002)

Ligand-field parameters of the f-electronic systems in a series of dinuclear lanthanide phthalocyaninato complexes have been determined. To study the systems without intermetallic interactions, new asymmetric hetero-dinuclear lanthanide phthalocyaninato complexes, PcYPcLnPc* (Pc = dianion of phthalocyanine, Pc* = dianion of 2,3,9,10,16,17,23,24-octabutoxyphthalocyanine and Ln = Tb, Dy, Ho, Er, Tm, and Yb), were prepared. The synthesis of the dinuclear complexes were achieved by the reaction of Pc2Y, H2Pc*, and Ln(acac)3·n(H2O). Measurements of magnetic susceptibility of powder samples of PcYPcLnPc* were carried out over the temperature range from 1.8 to 303 K. Using the multidimensional simplex minimization method, we obtained a set of ligand-field parameters that reproduces both the 1H NMR paramagnetic shifts and the magnetic susceptibility data. Ligand-field-splitting structure of the ground-state multiplets of the six lanthanide systems has been elucidated. A new computational approach to obtain ligand-field parameters is proposed for the situations in which sharp emission or absorption bands or both are not available.
Metabolites from nematophagous fungi and nematicidal natural products from fungi as alternatives for biological control. Part II: metabolites from nematophagous basidiomycetes and non-nematophagous fungi (2016)

In this second section of a two-part mini-review article, we introduce 101 further nematicidal and non-nematicidal secondary metabolites biosynthesized by nematophagous basidiomycetes or non-nematophagous ascomycetes and basidiomycetes. Several of these compounds have promising nematicidal activity and deserve further and more detailed analysis. Thermolides A and B, omphalotins, ophiobolins, bursaphelocides A and B, illinitone A, pseudohalonectrins A and B, dichomitin B, and caryopsomycins A-C are excellent candidates or lead compounds for the development of biocontrol strategies for phytopathogenic nematodes. Paraherquamides, clonostachydiol, and nafuredins offer promising leads for the development of formulations against the intestinal nematodes of ruminants.
Structural health and prognostics management for offshore wind turbines (2012)

Operations and maintenance costs for offshore wind plants are expected to be significantly higher than the current costs for onshore plants. One way in which these costs may be able to be reduced is through the use of a structural health and prognostic management system as part of a condition based maintenance paradigm with smart load management. To facilitate the creation of such a system a multiscale modeling approach has been developed to identify how the underlying physics of the system are affected by the presence of damage and how these changes manifest themselves in the operational response of a full turbine. The developed methodology was used to investigate the effects of a candidate blade damage feature, a trailing edge disbond, on a 5-MW offshore wind turbine and the measurements that demonstrated the highest sensitivity to the damage were the local pitching moments around the disbond. The multiscale method demonstrated that these changes were caused by a local decrease in the blade's torsional stiffness due to the disbond, which also resulted in changes in the blade's local strain field. Full turbine simulations were also used to demonstrate that derating the turbine power by as little as 5% could extend the fatigue life of a blade by as much as a factor of 3. The integration of the health monitoring information, conceptual repair cost versus damage size information, and this load management methodology provides an initial roadmap for reducing operations and maintenance costs for offshore wind farms while increasing turbine availability and overall profit.
Towards speaker adaptive training of deep neural network acoustic models (2014)

We investigate the concept of speaker adaptive training (SAT) in the context of deep neural network (DNN) acoustic models. Previous studies have shown success of performing speaker adaptation for DNNs in speech recognition. In this paper, we apply SAT to DNNs by learning two types of feature mapping neural networks. Given an initial DNN model, these networks take speaker i-vectors as additional information and project DNN inputs into a speaker-normalized space. The final SAT model is obtained by updating the canonical DNN in the normalized feature space. Experiments on a Switchboard 110- hour setup show that compared with the baseline DNN, the SAT-DNN model brings 7.5% and 6.0% relative improvement when DNN inputs are speaker-independent and speakeradapted features respectively. Further evaluations on the more challenging BABEL datasets reveal significant word error rate reduction achieved by SAT-DNN.
<i>Arabidopsis</i> RelA/SpoT homologs implicate (p)ppGpp in plant signaling (2000)

Arabidopsis RPP5 is a member of a large class of pathogen resistance genes encoding nucleotide-binding sites and leucine-rich repeat domains. Yeast two-hybrid analysis showed that RPP5 specifically interacts with At-RSH1, an Arabidopsis RelA/SpoT homolog. In Escherichia coli, RelA and SpoT determine the level of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), which are the effector nucleotides of the bacterial stringent response. Functional analysis in E. coli and in Streptomyces coelicolor A3 (2) showed that At-RSH1 confers phenotypes associated with (p)ppGpp synthesis. We characterized two additional Arabidopsis RelA/SpoT homologs, At-RSH2 and At-RSH3. At-RSH genes may regulate a rapid plant (p)ppGpp-mediated response to pathogens and other stresses.
Prohibición de acercamiento: el papel de la Administración Penitenciaria (2011)

El analisis que a continuacion se expone no hubiera sido posible sin la aportacion, en ideas y ganas, de los funcionarios de la Mesa 24 Horas, Oficina de Gestion y Departamento de Ingresos del Centro Penitenciario Madrid V para la puesta en marcha de los procedimientos que se describen. A ellos corresponde el mayor reconocimiento.
Extending frequency and bandwidth through the use of agile, high dynamic range photonic converters (2012)

RF photonic techniques can be used to extend operating frequencies and bandwidth of mission communications and sensing systems. Photonic links inherently cover wide frequency bandwidths and optical modulators and detectors have been demonstrated that operate up to 100 GHz. This paper presents a photonic method for tunable high frequency carrier generation and wideband tunable RF frequency conversion. Photonic down-conversion measurements are presented with +24 dBm OIP3 and positive gain across RF input signals from 5 to 20 GHz. Additionally, measurements of undesired higher order mixing spurious products were more than 30 dB lower than those of typical RF mixers. Coupling wide-band optical components with a reconfigurable RF payload provides unprecedented agility and multi-mission utility for remote sensing, communications and SAR radar missions.
A dielectric-loaded long conical horn for improved performance (2009)

A dielectric-loaded conical horn exhibiting improved radiation characteristics - low cross-polarization and side-lobes levels, pattern symmetry and good front-to-back ratio-is proposed. The dielectric insert is simpler than the ones proposed in two earlier papers, and is therefore easier to design and fabricate. The proposed horn may find wide applications in modern low cost high performance systems.