gebhart/patrepeval huggingface dataset:
The effect of butyrate on sulfated glycoprotein biosynthesis by human kidney tumor cells. (1981)

Human kidney tumor cells in culture incorporate [3H]glucosamine and 35SO4 into several classes of glycoconjugate products. After a 24-h labeling period, the 3H/35S-glycosaminoglycans and 3H-glycoproteins synthesized were found associated with both the cell layer and the culture medium. These tumor cells also synthesized a class of 35S-glycoproteins which contained alkali-stable 35S-oligosaccharide chains. These 35S-glycoproteins did not accumulate with the cell layers but were preferentially found in the culture medium (82-96%). After treatment with 2.5 mM butyrate for 24 h, the tumor cells assumed a more flattened and spread morphology with more clearly defined cell borders. These butyrate-treated cell cultures showed less than a 2-fold increase in the cell-associated form of both 3H/35S-glycosaminoglycans and 3H-glycoproteins, compared to cells cultured in the absence of butyrate. In contrast, butyrate-treated cell cultures had a 3-fold increase in the total incorporation of 35SO4 into glycoproteins and a dramatic 10-30-fold increase in the cell-associated form of these 35S-glycoprotein products as compared to untreated cell cultures.
Brief twice-weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus. (1998)

We tested the hypothesis that as few as two weekly brief episodes of superimposed hypoglycemia (i.e., doubling the average frequency of symptomatic hypoglycemia) would reduce physiological and behavioral defenses against developing hypoglycemia and reduce detection of clinical hypoglycemia in patients with type 1 diabetes mellitus (T1DM). Compared with nondiabetic controls, six patients with well-controlled T1DM (HbA1c, 7.5 +/- 0.7% [mean +/- SD]) exhibited absent glucagon responses and reduced epinephrine (P = 0.0027), norepinephrine (P = 0.0007), pancreatic polypeptide (P = 0.0030), and neurogenic symptom (P = 0.0451) responses to hypoglycemia as expected. In these patients, 2 h of induced hypoglycemia (50 mg/dl, 2.8 mmol/l) twice weekly for 1 month, compared in a random-sequence crossover design with an otherwise identical 2 h of induced hyperglycemia (150 mg/dl, 8.3 mmol/l) twice weekly for 1 month, further reduced the epinephrine (P = 0.0001) and pancreatic polypeptide (P = 0.0030) responses, tended to further reduce the norepinephrine and neurogenic symptom responses to hypoglycemia, and reduced cognitive dysfunction during hypoglycemia (P = 0.0271), all assessed in the investigational setting. In the clinical setting, induced hypoglycemia did not alter overall glycemic control, but did reduce the total number of symptomatic hypoglycemic episodes detected by the patients from 49 to 30 per month and lowered the mean +/- SE self-monitored blood glucose level during symptomatic hypoglycemia from 51 +/- 2 mg/dl (2.8 +/- 0.1 mmol/l) to 46 +/- 3 mg/dl (2.6 +/- 0.2 mmol/l) (P < 0.01). It also reduced the proportion of low regularly scheduled self-monitored values that were symptomatic by approximately 33%. Thus as little as doubling the frequency of symptomatic hypoglycemia further reduced both the key epinephrine response and clinical awareness of developing hypoglycemia, changes reasonably expected to increase the risk of severe iatrogenic hypoglycemia in T1DM.
Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography (2007)

Optical coherence tomography (OCT) is a micron scale high-resolution optical technology that can provide real-time in vivo images noninvasively. The ability to detect airway mucosal and submucosal injury rapidly will be valuable for a range of pulmonary applications including assessment of acute inhalation smoke and burn injury. OCT has the potential ability to monitor the progression of airway injury changes including edema, hyperemia, and swelling, which are critical clinical components of smoke-inhalation injury. New Zealand white male rabbits exposed to cold smoke from standardized unbleached burned cotton administered during ventilation were monitored for 6 h using a 1.8-mm diameter flexible fiberoptic longitudinal probe that was inserted through the endotracheal tube. The thickness of the epithelial, mucosal, and submucosal layers of the rabbit trachea to the tracheal cartilage was measured using a prototype superluminescent diode OCT system we constructed. OCT was able to detect significant smoke-injury-induced increases in the thickness of the tracheal walls of the rabbit beginning very shortly after smoke administration. Airway wall thickness increased to an average of 120% (+/-33%) of baseline values by 5 h following exposure. OCT is capable of providing real-time, noninvasive images of airway injury changes following smoke exposure. These studies suggest that OCT may have the ability to provide information on potential early indicators of impending smoke-inhalation-induced airway compromise.
Quantitating Defective Ribosome Products (2005)

The fidelity of the protein production process is monitored by quality control machinery, which ensures that aberrant proteins are not deployed throughout the cell. A significant fraction (upwards of 30%) of proteins are degraded by proteasomes shortly after their synthesis, and we have termed such proteins defective ribosomal proteins (DRiPs). It is of interest and importance to characterize qualitatively and quantitatively this cohort of rapidly degraded nascent proteins. Quantitating DRiPs entails employing a standard pulse-chase protocol using radiolabeled amino acids. Protein degradation kinetics can be determined by either acid precipitation or SDS-PAGE. The introduction of proteasome inhibitors enables quantitation of proteasome-mediated protein degradation in vivo.
Product quality and catalyst deactivation in a four day catalytic fast pyrolysis production run (2014)

Catalytic fast pyrolysis of pine sawdust was successfully carried out in VTT's 20 kg h−1 Process Development Unit using a spray dried HZSM-5 catalyst. Approximately 250 kg of partially deoxygenated pyrolysis oil was produced over a period of four days. The catalytically produced pyrolysis oil had an average moisture content of 8.3 wt%, and average carbon and oxygen contents of 72.0 and 21.5 wt% on a dry basis, respectively. Approximately 24% of the original biomass carbon was present in the pyrolysis oil, whereas 14% of carbon was in the form of aqueous side products, which totaled approximately 600 kg. The pyrolysis oil contained a high amount of lignin derived water-insoluble material, as well as 6.4 wt% of aromatic hydrocarbons. The majority of the carbohydrate derived products, i.e. acids, aldehydes, ketones and sugar-type compounds, were found in the aqueous product fraction. While the quality of pyrolysis oil remained quite stable during the four day experiment, distinct changes were observed in the properties and the behavior of the catalyst. Coke formation was heaviest at the beginning of the experiment, and then subsided over time. Catalyst micropore area and volume also decreased during the experiment. This transformation was accompanied by apparent changes in the crystallinity and the structure of the catalyst. Scanning electron microscope images of the catalyst also revealed clear physical damage to the particles. Biomass alkali metals also deposited on the catalyst, and the spent catalyst contained a total of 1.1 wt% of Ca, K, Mg and P after the experiment. A linear correlation was observed between catalyst alkali metal content and acidity, which indicated that biomass alkalis substituted the proton functionalities of the HZSM-5 acid sites.
Using Samba (2003)

From the Publisher:
Using Samba, which has been officially adopted by the Samba Team and is under the GNU Free Documentation License (FDL), is a comprehensive guide to Samba administration. The current edition focuses on Samba 2.2 and covers the most important features of 3.0, which was under development as this book went to print. Samba is a cross-platform triumph: it turns a Unix or Linux system into a file and print server for Microsoft Windows network clients. Samba is so robust, flexible, fast, and secure that many people are choosing it over Windows NT/2000/XP for their file and print services. Samba is also free software, licensed under the GNU General Public License. This book will help you make file and print sharing as robust, powerful, and efficient as possible. The authors delve into the internals of the Windows activities and protocols to an unprecedented degree, explaining the strengths and weaknesses of each feature in Windows domains and in Samba itself. Using Samba takes you from basic installation and configuration -- on both the client and server side, for a wide range of systems -- to subtle details of security, cross-platform compatibility, and resource discovery that make the difference between whether a user sees the folder they expect or a cryptic error message. The range of this book knows few bounds. Wondering how to integrate Samba's authentication with that of a Windows PDC? How to get Samba to serve Microsoft Dfs shares? How to share files on Mac OS X? These and a dozen other issues of interest to system administrators are covered. A whole chapter is dedicated to troubleshooting. Whether you're playing on one note or a full three-octave range, on your personal computer or an enterprise network, Using Samba will give you an efficient and secure server.
Hospital-level high-risk antibiotic use in relation to hospital-associated <i>Clostridioides difficile</i> infections: Retrospective analysis of 2016–2017 data from US hospitals (2019)

High-risk antibiotic use is an independent predictor of HA CDI. This assessment of poststewardship implementation in the United States highlights the importance of tracking trends of antimicrobial use over time as it relates to CDI.
Iron‐Catalyzed Alkylations of Aromatic Grignard Reagents. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preliminary Engineering Design of a Pulsed Homopolar Generator Power Supply (2016)

A 200 megajoule 500 volt homopolar generator system is proposed as the inertial storage-conversion device for the Texas Experimental Tokamak (TEXT). The initial engineering design of a 50 megajoule 125 volt homopolar generator module is presented and major components: yoke/field coil; rotor/shaft/bearings; brushes and armature conductors are described in detail. The support for this work was provided by the Energy Research and Development Administration (ERDA) and the Texas Atomic Energy Research Foundation (TAERF).
Low power delay calculation for digital beamforming in handheld ultrasound systems (2002)

In ultrasonic imaging, dynamic receive beamforming is performed with a delay-and-sum operation of the weighted outputs of the transducer elements. The required delay information depends on the position of the transducer elements and the time dependent focus. A new iterative algorithm for calculating this delay information for each channel individually was implemented as a power-optimized VLSI macro employing a tool for physical design oriented custom datapath generation. For a resolution of 1/8 of the sampling period, it comprises only 8 adders and 8 registers per channel and is one key component of a single-chip low power digital beamformer for use in battery operated handheld ultrasound scanners. Operating in a 40 MHz system at 3.3 V, it dissipates 2.1 mW in a 0.5-/spl mu/m CMOS process.
R&D infrastructures supported by the Operational Programme Research and Development for Innovation - human resources sustainability (2011)

Infrastruktury pro výzkum a vývoj podpořené z Operačního programu Výzkum a vývoj pro inovace - udržitelnost z hlediska lidských zdrojů Kvalita výzkumné infrastruktury v Česku byla zatím hodnocena v porovnání s vyspělými "západními" ekonomikami jako spíše podprůměrná. Zároveň je ale zřejmé, že dostupnost špičkové výzkumné infrastruktury je významným faktorem nejen pro kvalitní výzkum, ale i pro mezinárodní spolupráci či spolupráci s aplikačním sektorem. Dosavadní deficit ve sféře výzkumné infrastruktury by měly pomoci řešit současné operační programy a jejich prostřednictvím budovaná nová výzkumná centra. Jaký však bude efekt těchto nových výzkumných infrastruktur, závisí především na schopnostech či možnostech přivést do těchto center kvalitní výzkumné týmy a pracovníky. Příspěvek proto hodnotí z několika hledisek vývoj lidských zdrojů ve výzkumu a vývoji a dílčí trendy dává do souvislosti s indikovanými požadavky vznikajících center. Analýza ukazuje, že v dílčích oborech se může objevit potřeba počtu nových pracovníků, která překračuje nárůst zaměstnanosti odpovídající současným trendům, a tím ohrozit stávající či nová výzkumná centra, potažmo očekávané dopady spojené s jejich výstavbou.
On strongly degenerate parabolic problems with discontinuous coefficients (2003)

Abstract. It is shown that both a model of traffic flow with driver reaction and discontinu-ous road surface and a model of continuous sedimentation of flocculated suspensions give rise to strongly degenerate parabolic problems with discontinuous coefficients. For one of these models, an existence and uniqueness theory is outlined, which includes the conver-gence proof for a simple difference scheme. This scheme is used to produce numerical simulations of both applications.
Iterative reconstruction of fluorine-18 SPECT using geometric point response correction. (1998)

The proposed iterative reconstruction algorithm with geometric response correction is efficient and effective with significant resolution recovery.
Diffusion of immunoglobulin G from the vascular compartment into the normal rabbit cornea. (1990)

In order to study the rate of entry of IgG into the normal cornea, IgG specific for human serum albumin was injected intravenously over a 2-month period into nonimmunized rabbits. The concentrations of total immunoglobulin G (IgG) and IgG specific for human serum albumin in serum, corneal tissue, and aqueous humor were determined with enzyme-linked immunosorbent assays. The experiments showed that the corneal concentration of IgG specific for human serum albumin increased by approximately 1% per day, whereas the total IgG concentration of the corneas used in this study was 70% of the concentration detected in serum. On the basis of these data it was hypothesized that an equilibrium between the serum and corneal IgG concentration was established after approximately 70 days. By injecting IgG preparations with different isoelectric point ranges, the influence of electrostatic interactions on the rate of entry into the cornea was investigated. It was found that charge had no effect on diffusion. From these results it was concluded that, after an antigenic stimulation, newly synthesized antibodies will be confined to the limbal region and will be noted only gradually at points nearer to the center. This indicates that the role of IgG during the immediate inflammatory response of the cornea is limited.
Phase retrieval for high-numerical-aperture optical systems (2003)

We describe a phase retrieval approach for intensity point-spread functions of high-numerical-aperture optical systems such as light microscopes. The method calculates a generalized pupil function defined on a spherical shell, using measured images at several defocus levels. The resultant pupil functionsreproduce measured point-source images significantly better than does an ideal imaging model. Availability of pupil function information will facilitate new approaches to aberration correction in such systems.
Ventana Fenestrated Stent-Graft System for Endovascular Repair of Juxtarenal Aortic Aneurysms (2012)

There exists an unmet clinical need for a broadly applicable endovascular option for repair of more complex juxtarenal or pararenal aortic aneurysms. These cases suggest that endovascular repair of such aneurysms using the Ventana fully integrated off-the-shelf stent-graft system is safe and feasible.
Human alternative complement pathway-mediated lysis of rabbit erythrocytes is enhanced by natural anti-Galalpha1-3Gal antibodies (1997)

Human serum is effective at lysing unsensitized rabbit erythrocytes due to activation of the alternative complement pathway. Hemolysis is known to be enhanced by the addition of human IgG. We demonstrate that the enhancement of alternative pathway-mediated rabbit E lysis by human Ig is due to natural Abs specific for galactosyl (Gal)alpha1-3Gal. Depletion of normal human serum (NHS) of anti-Galalpha1-3Gal Abs removes almost all hemolytic activity from NHS, and activity can be restored by repletion with anti-Galalpha1-3Gal affinity-purified Abs. Factor B-depleted serum (inactive alternative pathway) did not lyse rabbit erythrocytes. Although C2-depleted serum was fully hemolytic, activity was removed by depletion of anti-Galalpha1-3Gal Abs. Of the total anti-Galalpha1-3Gal Abs affinity isolated from NHS, about one-third were IgM and two-thirds were IgG. Both anti-Galalpha1-3Gal IgG and IgM enhanced alternative pathway-mediated erythrocyte lysis.
Antioxidative effects of sesamol and tocopherols at various concentrations in oils during microwave heating (1999)

The effectiveness of sesamol and tocopherols or their mixtures at different concentrations (50 to 800 ppm) on the oxidative stability of tocopherol-stripped oils was studied under microwave heating conditions. Microwave heating accelerated the oxidation of the purified substrate oils. The oxidative deterioration of the oils was significantly (P<0.05) retarded during microwave heating by the addition of sesamol or tocopherols, and also mixtures of these antioxidants. A combination of sesamol and γ-tocopherol was more efficient than that of sesamol and the other tocopherol homologues in inhibiting hydroperoxide formation in the oils. Useful levels of these antioxidants were 400 ppm for tocopherols and 50–400 ppm for sesamol. In general, the residual amount of sesamol in the oils during microwave heating was significantly greater (P<0.05) than that of tocopherols. Very effective combinations of tocopherols and sesamol as antioxidants for the purified oils were 200 or 400 ppm of γ-tocopherol and 50, 200 or 400 ppm of sesamol, respectively. © 1999 Society of Chemical Industry
Surface Engineering Method to Fabricate a Bendable Self-Cleaning Surface with High Robustness (2013)

Self-cleaning is a common phenomenon in natural world and has wide applications in people's real life. Here we report a general surface engineering method to fabricate micro/nano hybrid structure on polymer film, which can be applied to other substrates. The modified polymer surface is superhydrophobic with a water contact angle (CA) of 160 +/- 1 degrees and a water sliding angle (SA) of 3 degrees. When bent to two opposite directions, the convex surface and concave surface are still superhydrophobic and exhibit self-cleaning property. Dusts with different sizes can be cleared away from the modified surface by dipping water drops or spraying water mist. The surface engineering method modified surface has ultrahigh robustness. Its perfect multi-scale hierarchical structure and self-cleaning property barely change even after undergoing one hour ultrasonic oscillation. This method is applicable to modify the surfaces of various materials, architectures and devices into self-cleaning surfaces.
Soluble intercellular adhesion molecule-1 levels in patients with psoriasis (1993)

A newly developed ELISA was used to detect and quantify the presence of a soluble form of intercellular adhesion molecule-1 (sICAM-1) in the circulation of healthy individuals compared with patients with psoriasis vulgaris. Seventeen psoriatic patients were studied. The extent of skin lesions was rated by the psoriasis area and severity index (PASI). Seventeen age- and sex-matched healthy individuals served as controls. Serum levels were measured by an ELISA technique utilizing an anti-ICAM-1 murine monoclonal antibody bound to the solid phase, and a second, peroxidase-conjugated monoclonal antibody reacting with sICAM-1. Serum levels in controls were 358.8 +/- 87.9 ng/ml sICAM-1, and 480.5 +/- 133.6 ng/ml in psoriatics (mean +/- SD; P = 0.02). In psoriasis, sICAM-1 levels were found to be directly proportional to the PASI score (y = 363.002 + 8.525x, R = 0.55, P = 0.021). These data suggest that the concentration of sICAM-1 in serum increases during psoriatic inflammation. The origin and function of sICAM-1 in psoriasis remain to be defined.
Controllability of a 3-DOF manipulator with a passive joint under a nonholonomic constraint (2002)

Controllability of a manipulator with a passive joint which has neither an actuator nor a holding brake is investigated. The manipulator has 3 degrees of freedom in a horizontal plane and the third joint is passive. The dynamic constraint on the third link is 2nd-order nonholonomic. The controllability is proved by constructing examples of the input trajectories from arbitrary initial slates to arbitrary desired slates. The proof is intuitively understandable, and the construction of the input directly leads to the trajectory planning. Simulations show that the manipulator can reach the desired position and velocity by the constructed input.
Aromatic Trifluoromethylation with Metal Complexes (2011)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTAromatic Trifluoromethylation with Metal ComplexesOlesya A. Tomashenko and Vladimir V. Grushin*View Author Information The Institute of Chemical Research of Catalonia (ICIQ), Tarragona 43007, SpainE-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 8, 4475–4521Publication Date (Web):April 1, 2011Publication History Received15 December 2010Published online1 April 2011Published inissue 10 August 2011https://pubs.acs.org/doi/10.1021/cr1004293https://doi.org/10.1021/cr1004293review-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views25169Altmetric-Citations1552LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Aromatic compounds,Metals,Reagents,Trifluoromethylation Get e-Alerts
Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells (2008)

Rapid identification of known and novel SFK targets in CRC cells is feasible with SH2 domain affinity chromatography. The elucidation of new SFK targets like Odin in epithelial cancer cells is expected to lead to novel insight into cancer cell signalling mechanisms and may also serve to indicate new biomarkers for monitoring tumor cell responses to drug treatments.