gebhart/patrepeval huggingface dataset:
Inositol safety: clinical evidences. (2011)

Myo-inositol is a six carbon cyclitol that contains five equatorial and one axial hydroxyl groups. Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). However, despite its wide clinical use, there is still scarce information on the myo-inositol safety and/or side effects. The aim of the present review was to summarize and discuss available data on the myo-inositol safety both in non-clinical and clinical settings. The main outcome was that only the highest dose of myo-inositol (12 g/day) induced mild gastrointestinal side effects such as nausea, flatus and diarrhea. The severity of side effects did not increase with the dosage.
Transformation of somatic embryos of Vitis sp. (grapevine) with different constructs containing nucleotide sequences from nepovirus coat protein genes (1996)

1996. Transformation of somatic e m b r y o s o f Vitis sp. (grapevine) with different constructs containing nucleotide sequences from nepovirus coat protein genes. Arqiiipe'lngo. L i f e a n d M a r i n e Sciences 14A: 67-74. Ponta Delgada. ISSN 08734704. Breeding of grapevines. one of the world's most widcly-grown fruit crop, as in the case with many woody crops, is hampered by genetic heterozygozity and long generation time. Transformation offcrs new alternatives in the genetic improvement of grapevine. Nepovimses are the grapevine viruses of greatest economic importance because of their worldwide occurrence and the severe damages they cause. An Agrobncteriurn-mediated gene transfer system relying on repetitive embryogencsis has been used to regenerate transgenic grapevines. Embryogenic cultures of Vitis vinifera (Russalka - selfpollinatcd) and 1 10 Richter (Vitis rupestris x Vitis berlandieri) were transformed with Agrobacteriron turnefacierzs strain LBA 4404 containing various binary plasmids. pBinCUSint. carrying the marker gene P-glucuronidasc (GUS). and seven different constructs containing chimeric coat protein (CP) genes of grapevine fanleaf virus (CFLV), including nontranslatable and truncated forms of the CP gene. and arabis mosaic virus (ArMV), respectively. Putative transformed embryos werc selected by continued proliferation on kanamycin containing medium. Embryos transformed with the plasmid pBinCUSint were shown to exprcss the GUS gene by histochemical analyses.
Preferred skin color enhancement for photographic color reproduction (2010)

Skin tones are the most important colors among the memory color category. Reproducing skin colors pleasingly is an important factor in photographic color reproduction. Moving skin colors toward their preferred skin color center improves the color preference of skin color reproduction. Several methods to morph skin colors to a smaller preferred skin color region has been reported in the past. In this paper, a new approach is proposed to further improve the result of skin color enhancement. An ellipsoid skin color model is applied to compute skin color probabilities for skin color detection and to determine a weight for skin color adjustment. Preferred skin color centers determined through psychophysical experiments were applied for color adjustment. Preferred skin color centers for dark, medium, and light skin colors are applied to adjust skin colors differently. Skin colors are morphed toward their preferred color centers. A special processing is applied to avoid contrast loss in highlight. A 3-D interpolation method is applied to fix a potential contouring problem and to improve color processing efficiency. An psychophysical experiment validates that the method of preferred skin color enhancement effectively identifies skin colors, improves the skin color preference, and does not objectionably affect preferred skin colors in original images.
Regulation of Tumor Cell Chemotaxis by Type IV Collagen Is Mediated by a Ca2+-dependent Mechanism Requiring CD47 and the Integrin αVβ3 (2000)

Studies from our laboratories demonstrated that synthetic peptides from the non-collagenous (NC-1) domain of the alpha3 (IV) chain of type IV collagen (COL IV) enhanced tumor cell adhesion (Han, J., Ohno, N., Monboisse, J. C., Pasco, S., Borel, J. P., and Kefalides, N. A. (1997) J. Biol. Chem. 272, 20395-20401). We have isolated the receptors for the alpha3(IV)185-203 peptide from melanoma and prostate tumor cells and identified them as CD47/integrin-associated protein and the integrin alpha(V)beta(3) (Shahan, T. A., Ziaie, Z., Pasco, S., Fawzi, A., Bellon, G., Monboisse, J. C., and Kefalides, N. A. (1999) Cancer Res. 59, 4584-4590). In the present study we have examined the effect of CD47 and the integrin alpha(V)beta(3) on in vitro tumor cell chemotaxis and Ca(2+)(i) modulation in response to COL IV, from the anterior lens capsule (ALC-COL IV) and peptides from its NC-1 domain. COL IV as well as the alpha3(IV) peptide promoted tumor cell chemotaxis with an immediate increase in intracellular [Ca(2+)]. Treating tumor cells with CD47 and integrin alpha(V)beta(3)-reactive antibodies reduced chemotaxis as well as the rise in [Ca(2+)](i) in response to ALC-COL IV or the alpha3(IV)185-203 peptide but not to Engelbreth-Holm-Swarm-COL IV or fibronectin. The alpha3(IV)185-203 synthetic peptide stimulated an increase in calcium from intracellular stores exclusively, whereas ALC-COL IV, Engelbreth-Holm-Swarm-COL IV, and fibronectin stimulated Ca(2+) flux from both internal and external stores. Furthermore, treatment of the cells with Ca(2+) chelator bis-(O-aminophenoxyl)ethane-N,N,N',N'-tetraaceticacid- acetomethoxy ester inhibited chemotaxis toward both ALC-COL IV and the alpha3(IV)185-203 peptide. These data indicate that CD47 and integrin alpha(V)beta(3) regulate tumor cell chemotaxis in response to COL IV and the alpha3(IV)185-203 peptide through a Ca(2+)-dependent mechanism.
Current Trends in Managing Oral Mucositis (2005)

Oral mucositis is an inflammatory and ulcerative process of the oral cavity that results from an assault on the epithelial mucous membrane tissue and most commonly is associated with the administration of radiotherapy and chemotherapy. The incidence of oral mucositis ranges from 15%-40% in patients receiving stomatotoxic chemotherapy or radiotherapy and 70%-90% in bone marrow recipients. Knowledge regarding the pathophysiology of oral mucositis has evolved and now guides practice. Assessment tools to measure the level of mucositis provide valuable data concerning the status of the oral cavity. No single oral assessment tool has been found to be appropriate in all clinical settings. Mucositis has a significant impact on patients' quality of life and treatment plan. Management of oral mucositis is aimed at minimizing this side effect and its subsequent sequelae. The strategies of care are geared toward early intervention and supportive care for patients at risk for developing mucositis and include specific targeted therapies for the management of debilitating side effects. This article provides an overview of the risk factors, pathophysiology, incidence, impact, clinical presentation, oral assessment tools, management strategies, and nursing implications related to oral mucositis.
INFLUENCE OF BLUR ON FEATURE MATCHING AND A GEOMETRIC APPROACH FOR PHOTOGRAMMETRIC DEBLURRING (2015)

Unmanned aerial vehicles (UAV) have become an interesting and active research topic for photogrammetry. Current research is based on images acquired by a UAV, which have a high ground resolution and good spectral and radiometric resolution, due to the low flight altitudes combined with a high resolution camera. UAV image flights are also cost efficient and have become attractive for many applications including change detection in small scale areas. One of the main problems preventing full automation of data processing of UAV imagery is the degradation effect of blur caused by camera movement during image acquisition. This can be caused by the normal flight movement of the UAV as well as strong winds, turbulence or sudden operator inputs. This blur disturbs the visual analysis and interpretation of the data, causes errors and can degrade the accuracy in automatic photogrammetric processing algorithms. The aim of this research is to develop a blur correction method to deblur UAV images. Deblurring of images is a widely researched topic and often based on the Wiener or Richardson-Lucy deconvolution, which require precise knowledge of both the blur path and extent. Even with knowledge about the blur kernel, the correction causes errors such as ringing, and the deblurred image appears “muddy ” and not completely sharp. In the study reported in this paper, overlapping images are used to support the deblurring process, which is advantageous. An algorithm based on the Fourier transformation is presented. This works well in flat areas, but the need for geometrically correct sharp images may limit the application. Deblurring images needs to focus on geometric correct deblurring to assure geometric correct measurements. * Corresponding author.
Gefüge‐ und Eigenschaftsänderungen von hitzebeständigen Chrom‐Aluminium‐ und Chrom‐Silizium‐Stählen durch Stickstoffaufnahme (1937)

Bildung von Austenit und bei Vorhandensein von Aluminium von Aluminiumnitrid in ferritisch‐karbidischen Chrom‐Aluminium‐ und Chrom‐Silizium‐Stählen durch Stickstoffeinwanderung beim Glühen in Luft, Verbrennungsgasen oder in Stickstoff. Einwirkung der Stickstoffeinwanderung auf Grobkornbildung, elektrische Leitfähigkeit und Zunderbeständigkeit.
Application of a maximum likelihood estimator in an experimental study in ultrasonic diffraction tomography (1993)

A recently proposed approach to the inverse problem of detecting the presence and estimating the location of a known object from data collected in a set of diffraction tomographic experiments is evaluated. Experimental data are used to validate of the filtered backpropagation algorithms used, and their robustness to modeling errors and to severe limitations in the angular coverage of the tomographic data is demonstrated. A potential application to medical imaging of soft tissue is illustrated.
High Serum Lactate Dehydrogenase Level as a Marker for Drug Resistance and Short Survival in Multiple Myeloma (1991)

Elevation of the LDH level suggests the presence of occult extraosseous disease and high tumor mass. The LDH level is a predictor of a poor prognosis in selected patients who should be considered for early intensive treatment.
Fast-steering mirrors in optical control systems (1990)

This paper contains a discussion of the functions of fast steering mirrors (FSMs) in optical systems which include target tracking, attenuation of disturbances including jitter, alignment beam and image stabilization, and extending optical sensor linear range. Dynamic and control modeling of the FSM mechanism, actuators, position sensors, and controllers are described in terms of mass and inertia properties, dynamic range, and bandwidth. Illustrative examples of the use of FSMs in optical systems and a simulation of a representative optical system using an FSM and corresponding results are shown. The use of software tools in performing control systems simulations is discussed.
Ontwrichting van tweezijdige markten door platformen (2018)

Door te profiteren van netwerkeffecten kunnen platformbedrijven economische waarde creëren en werken ze als een magneet voor datagedreven innovatie. Schaalgrootte en marktmacht stellen echter wel eisen aan een evenwichtig regelgevingskader.
The sequential analysis of trisomy 12 in B‐cell chronic lymphocytic leukaemia (1999)

In this longitudinal study we evaluated the clinical significance of screening for trisomy 12 by fluorescence in situ hybridization (FISH) and correlated these findings with survival, disease progression and need for treatment. Interphase FISH was performed on 85 patients in 1993/94 and repeated on 41 patients in 1996/97. Over the 4-year period there was no significant change in the percentage of trisomic cells, even in patients with disease progression. Overall survival and requirement for treatment were similar for patients with and without FISH-defined trisomy 12.
Origin of High Mobility in Molybdenum-Doped Indium Oxide (2015)

Molybdenum-doped indium oxide (IMO) thin films prepared by aerosol-assisted chemical vapor deposition (AACVD) show significantly improved charge carrier mobilities as compared to nominally undoped films prepared by the same technique. The basis for this very unusual behavior has been investigated by density functional theory calculations using a hybrid Hamiltonian, mobility modeling, X-ray photoemission, and X-ray absorption spectroscopies. In contrast to previous claims that Mo acts as a three-electron donor, it is shown that substitutional Mo traps two electrons in localized states falling within the bulk bandgap and thus Mo is a simple one-electron donor. At the same time, there is very little hybridization of Mo 4d states with In 5s states at the bottom of the conduction band. This results in conduction that is spatially separated to some degree from the donors, giving rise to significantly reduced ionized impurity scattering, enhancing the carrier mobility. This is in contrast to Sn-doped In2O3 where the conduction band minimum has significant Sn 5s character, resulting in regular ionized impurity scattering.
Feasibility study of I&#x0395;&#x0395;&#x0395; 802.11ah radio technology for IoT and M2M use cases (2012)

In this paper we study the feasibility of IEEE 802.11ah radio technology for internet of things (IoT) and machine to machine (M2M) use cases. Devices in internet of things and machine to machine networks are foreseen to communicate wirelessly. Therefore, it is of foremost importance to have a reliable, low-energy wireless technology available that may be used anywhere and anytime without draining the device battery and could achieve satisfactory coverage and data rate. Here we study the link budget, achievable data rate and packet size design of the IEEE 802.11ah radio technology in different channel scenarios. System design and simulation results show that when using this technology the system parameters can be selected to satisfy in most of the cases a reliable communication link while providing better coverage and relatively comparable throughput when compared to other existing solutions like ZigBee.
Induction of apoptosis by iron deprivation in human leukemic CCRF-CEM cells. (1995)

It is known that iron is essential for cell growth and viability and that iron deprivation results in an inhibition in the synthesis of deoxyribonucleotides. However, steps leading to eventual cell death during iron deprivation are not fully understood. In the present study, we report that cellular iron-deficiency produced by exposure of human leukemic CCRF-CEM cells to gallium or the iron chelator deferoxamine (DFX) resulted in the inhibition of cell growth, condensation of chromatin, and the formation of DNA fragments (DNA-ladder), findings that are characteristic of apoptotic cell death. These effects of gallium and DFX were detected after a 48-hour incubation with cells and could be prevented by ferric ammonium citrate (FAC). Iron-deprivation produced a small increase in the endogenous expression of bcl-2 protein. Our studies provide additional information regarding the mechanism of cytotoxicity of gallium and DFX, and suggest, for the first time, a role for iron in the suppression of apoptotic cell death.
Accuracy of Prediction Instruments for Diagnosing Large Vessel Occlusion in Individuals With Suspected Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke (2018)

No scale predicted LVO with both high sensitivity and high specificity. Systems that use LVO prediction instruments for triage will miss some patients with LVO and milder stroke. More prospective studies are needed to assess the accuracy of LVO prediction instruments in the prehospital setting in all patients with suspected stroke, including patients with hemorrhagic stroke and stroke mimics.
[Reconstruction of three different kinds of tympanic membrane in vitro by tissue engineering technique]. (2008)

The results suggest that the tension and the thinkness of acellular dermal matrix is similar to the normal tympanic membrane of guinea pig, it is an ideal material for tympanoplasty.
Cutting Temperature and Tool Wear Characteristics of Cylindrical Rotary Cutting Tools (1971)

The investigation of cutting temperature and tool wear characteristics of the rotary cutting tool is important to perform its machinerbility analysis. In this paper, cutting temperature is measured by a new temperature measuring equipment. A garter spring devise is used pik up the output signals from thermocouple wires. The tool wear characteristics is also examined. The following conclusions are obtained :1) The cycle of hearting and cooling in cutting temperature due to tip rotation is considerably large. The maximum temperature of the rotating tip is extreamly lower than that of the fixed tip. The differences in cutting temperature are mainly arisen by the increase in cooling effect due to tip rotation and the difference in cutting mechanics.2) The wear of the rotary cutting tool initiate at the corner of the cutting edge and the cutting edge is rounded off as the wear increases. The wear rate of the rotary cutting tool is very small and the tool life increases considerably even in cutting of the Titanium alloy, which is one of refractory materials.
Environmental Aspects of Legionnaires’ Disease (1988)

This article reviews the clinical symptoms of legionnaires’ disease, describes the natural and man‐made habitats of Legionella pneumophila , and evaluates various disinfection methods. Although heat rejection devices (cooling towers and evaporative condensers) have been linked to outbreaks of legionnaires’ disease, recent evidence suggests that potable water distribution systems are the primary reservoirs of L. pneumophila . Inhalation of aerosols containing the organism, instillation of the organism into the lung via medical maneuvers of the respiratory tract, and aspiration of contaminated water into the lung are the most likely modes of transmission of L. pneumophila . Treatment methodologies include hyperchlorination, thermal eradication, ozonation, and ultraviolet light irradiation.
ST-UNet: A Spatio-Temporal U-Network for Graph-structured Time Series Modeling (2019)

The spatio-temporal graph learning is becoming an increasingly important object of graph study. Many application domains involve highly dynamic graphs where temporal information is crucial, e.g. traffic networks and financial transaction graphs. Despite the constant progress made on learning structured data, there is still a lack of effective means to extract dynamic complex features from spatio-temporal structures. Particularly, conventional models such as convolutional networks or recurrent neural networks are incapable of revealing the temporal patterns in short or long terms and exploring the spatial properties in local or global scope from spatio-temporal graphs simultaneously. To tackle this problem, we design a novel multi-scale architecture, Spatio-Temporal U-Net (ST-UNet), for graph-structured time series modeling. In this U-shaped network, a paired sampling operation is proposed in spacetime domain accordingly: the pooling (ST-Pool) coarsens the input graph in spatial from its deterministic partition while abstracts multi-resolution temporal dependencies through dilated recurrent skip connections; based on previous settings in the downsampling, the unpooling (ST-Unpool) restores the original structure of spatio-temporal graphs and resumes regular intervals within graph sequences. Experiments on spatio-temporal prediction tasks demonstrate that our model effectively captures comprehensive features in multiple scales and achieves substantial improvements over mainstream methods on several real-world datasets.
Overexpression of D-psicose 3-epimerase from <em>Clostridium cellulolyticum</em> H10 in <em>Bacillus subtilis</em> and its Prospect for D-psicose Production (2013)

The aim of this study was to overexpress the D-psicose 3-epimerase from <em>Clostridium cellulolyticum</em> H10 in food-grade microbe. This gene was cloned and expressed in <em>Bacillus subtilis</em>. The results showed that the recombinant protein was soluble, bioactive, and expressed at high levels. The optimum pH and temperature of the enzyme were 8.0 and 50°C, respectively. The activity of the enzyme was not dependent on metal ions; however, some metal ions, such as $Co^{2+}$, can make the enzyme more thermostable. The Michaelis-Menten constant (K<sub>m</sub>) of the enzyme for D-psicose was much lower than that for D-tagatose, suggesting that the optimum substrate of the enzyme is D-psicose. D-Psicose 3-epimerase expressed in the food-grade <em>B. subtilis</em> may be used for the industrial production of D-psicose.
The practical utility and explanatory adequacy of applied linguistic relativism (2013)

A critical, deflationary analysis is offered of two recently popularised applications of linguistic relativism. The first application concerns the defence mounted via linguistic relativism for national single-language policy, on the assumption that a linguistically homogeneous society is more likely to engender national stability than one which is multi-lingual. Empirical data are assembled that contradict in several ways the argument underlying this social engineering initiative. A second application of linguistic relativism purports to explain economic underdevelopment in certain language communities as a consequence of their dysfunctional beliefs about time. Philosophical work done in analysing the conditions required for ‘radical interpretation’ is marshalled to demonstrate the incoherence of attempting to explain apparent differentials in rates of national economic development worldwide as a function of linguistic relativism.
Feasibility and Reliability of Ankle/Arm Blood Pressure Index in Preventive Medicine (2000)

Despite its potential usefulness for assessing preclinical atherosclerosis and cardiovascular risk, the ankle/arm blood pressure index (AAI) has not yet been the matter of study evaluating its feasibility and reliability by nonspecialist doctors in a general population. This study was planned for two steps. In step 1, the measurement of AAI, (ratio between Doppler systolic pressure at the ankle for each lower limb and the highest value of Doppler systolic pressure of the two upper limbs), should be performed by 50 general practitioners (GPs), 50 social security center physicians, and 50 occupational health physicians in 3,000 male smokers, 40 to 59 years, without clinical cardiovascular disease. In step 2, AAI measurement, coupled with echography-Doppler of iliofemoral arteries, should be repeated by a specialist in all subjects with decreased AAI (<0.90) and the first two subjects with normal AAI recruited in step 1 by each nonspecialist. The number of physicians and subjects participating in step 1 was lower than planned (80 physicians and 962 subjects) with the greatest defect for GPs (six physicians and 35 subjects) and the prevalence of decreased AAI was low (28 subjects). AAI measurement was repeated in step 2 in only 12 subjects with decreased AAI in step 1 and in 124 subjects with normal AAI in step 1. Five of the six subjects with decreased AAI in step 2 also had decreased AAI in step 1 and 123 of the 130 subjects with normal AAI in step 2 also had normal AAI in step 1. As regards echographic stenosis, decreased AAI had a sensitivity of 44% and a specificity of 98%. AAI seems more feasible for occupational health physicians and social security center physicians and AAI is also reliable for nonspecialists previously trained, but its predictive value as regards echographic stenosis is poor in asymptomatic subjects, which may limit its usefulness for detecting preclinical atherosclerosis.