gebhart/patrepeval huggingface dataset:
Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo (2011)

The known, precise and consistent gene composition of this cancer mesenchymal transition signature, particularly when combined with simultaneous analysis of the adjacent microenvironment, provides unique opportunities for shedding light on the underlying mechanisms of cancer invasiveness as well as identifying potential diagnostic markers and targets for metastasis-inhibiting therapeutics.
Prospective Validation of Immunological Infiltrate for Prediction of Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer – A Substudy of the Neoadjuvant GeparQuinto Trial (2013)

Confirming previous investigations of our group, we have prospectively validated in an independent cohort that an increased immunological infiltrate in breast tumor tissue is predictive for response to anthracycline/taxane-based NACT. Patients with LPBC and increased stromal lymphocyte infiltration have significantly increased pCR rates. The lymphocytic infiltrate is a promising additional parameter for histopathological evaluation of breast cancer core biopsies.
Radioimmunoassay for Zearalenone and Zearalanol in Human Serum: Production, Properties, and Use of Porcine Antibodies (1983)

To produce antigens susceptible to raise antibodies for resorcylic acid lactones, the 6'-carboxymethyloxime derivatives of zearalenone and zearalanone were bound to bovine serum albumin. Pigs could be immunized by using these antigens, the best titer in antibodies being obtained with the zearalenone antigen. The porcine antibodies were specific for the resorcylic acid lactones of structural resemblance with zearalenone. This specificity made the antibodies usable for a radioimmunoassay of zearalenone and zearalanol, which may be found in human and animal sera. The range of the assay was between 0.25 and 10 ng. The limit of detection was 5 ppb (5 ng/ml) in human serum.
From Dogfish to Dogs: Trimethylamines Protect Proteins from Urea (1986)

The accumulation of methylamine solutes to counteract perturbation of proteins by urea seems to be an important and phylogenetically widespread phenomenon. In the renal papilla of the mammalian kidney, the accumulation of methylamines appears to solve two distinct problems. The "osmotic gap" may be largely filled by methylamines and urea, and, because methylamines appear to be accumulated to about one-half the concentration of urea, they are likely to offset fully the influences of urea on intracellular proteins. How the kidney cells accumulate and retain methylamines and how they adjust mehtylamine concentrations int he face of fluctuations in urea levels remain fascinating and important questions for physiologists to resolve.
Characterization of denaturation and renaturation of DNA for DNA hybridization (2014)

Among all the physical methods applied, the direct probe sonication was the most effective way to denature the DNA fragments. Among chemical methods, 60% DMSO was the most adequate denaturation method since it does not cause full renaturation during DNA hybridization.
General theory of excitation in ion cyclotron resonance mass spectrometry (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral theory of excitation in ion cyclotron resonance mass spectrometryPeter B. Grosshans and Alan G. MarshallCite this: Anal. Chem. 1991, 63, 18, 2057–2061Publication Date (Print):September 15, 1991Publication History Published online1 May 2002Published inissue 15 September 1991https://pubs.acs.org/doi/10.1021/ac00018a030https://doi.org/10.1021/ac00018a030research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Passive Integrations for Г-Z Source & DAB DC-AC Bidirectional Converter (2019)

In order to increase the stability and improve the transfer efficiency of PV (Photovoltaic) micro-inverter, match the requirement of grid and achieve a clean energy, a novel topology is put forward which consists one ⌈-Z source boost converter, one DAB (dual-active bridge) converter for DC to DC, one inverter with LCL filter, and one DAB converter for battery. Furthermore, two integrated units for ⌈-Z source and LCL filter with planar PCB (printed circuit board) integration technique, and one integrated unit for two DAB converters with FMLF (flexible multi-layer foil) integration technique are proposed to reduce the volume and weight of the novel topology. Moreover, the parameter design of the FMLF integrated unit is underlined. And one prototype is built to prove the feasibility of the proposed ideas for a 400 W novel topology.
Bruce J. Dickson, <i>Political Implications of Red Capitalists in China</i>, Cambridge: Cambridge University Press, 2003 (2003)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
The Genetics of Alzheimer Disease (2012)

Family history is the second strongest risk factor for Alzheimer disease (AD) following advanced age. Twin and family studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (,60 years) familial AD, which represents 5% of AD. On the other hand, common gene polymorphisms, such as the 14 and 12 variants of the APOE gene, can influence susceptibility for 50% of the common late-onset AD. These four genes account for 30% -50% of the inheritability of AD. Genome-wide association studies have recently led to the identification of 11 additional AD candidate genes. This paper reviews the past, present, and future attempts to elucidate the complex and heterogeneous genetic underpinnings of AD.
Cardiac output and its distribution in the chicken (1959)

The cardiac output of the chicken has been measured by the indicator dilution technique and its distribution determined by the indicator distribution technique. The cardiac output is 218 ml/kg/min. The coronary flow fraction is 4.9% of the cardiac output, the renal flow fraction, 15.2% of the cardiac output, and the splanchnic flow fraction, 17.4% of the cardiac output. The perfusion rates of the thyroid and adrenal glands are similar to those found in the rat.
Multiply‐polarized shear‐wave VSPs from the Cajon Pass Drillhole (1988)

A 3‐component VSP data set was acquired in the Cajon Pass Drillhole, with a multiply‐polarized shear‐wave source and a conventional P‐wave source, producing a 9‐component data set. The VSP data show effects on the full wavefield from the sediment‐granite interface. Mode‐converted waves are identified, with significant scattering of S‐wave energy from the leading P‐wavefront. Hodographs are used to display S‐wave particle motions in two dimensions. Shear‐wave splitting is observed in the hodographs. The shear‐wave particle motion is used to infer anisotropy orientation with respect to the local strike of the San Andreas fault. Stress‐induced fracturing is assumed to be a possible cause of the shear‐wave splitting. A variation of particle motion orientation with depth is observed, implying a variation in anisotropy orientation as a function of depth.
RanBP2 associates with Ubc9p and a modified form of RanGAP1 (1997)

Ran is a small GTPase required for nuclear transport in eukaryotic cells [Gorlich, D. & Mattaj, I. W. (1996) Science 271, 1513-1518]. Mutants in Ran also show defects in mRNA processing, cell cycle regulation, and other aspects of nuclear function [Rush, M. G., Drivas, G. & D'Eustachio, P. (1996) BioEssays 18, 103-112; Sazer, S. (1996) Trends Cell Biol. 6, 81-85]. In an effort to understand the role of Ran in these diverse processes, we previously characterized 10 Ran interacting proteins (Rips) from Xenopus egg extracts. In this report, we present further characterization of a complex containing three of these Rips: p340(RanBP2), p88, and p18. We have cloned the Xenopus homologue of RanGAP1, and we show here that p88 is a modified form of this protein. In RanGAP assays, the p340(RanBP2)-p88-p18 complex contains GTPase-activating protein activity, indicating that RanGAP1 is not inactivated by modification. Rather, modification of RanGAP1 appears to be linked to its association with p340(RanBP2) because we did not observe unmodified RanGAP1 in p340(RanBP2) immunoprecipitates. We have also characterized p18, and we found that it is the Xenopus homologue of Ubc9p, an E2 ubiquitin-conjugating enzyme that is required for cell cycle regulation [Seufert, W., Futcher, B. & Jentsch, S. (1995) Nature (London) 373, 78-81]. Using antibodies directed against Xenopus Ubc9p, we have confirmed that Ubc9p associates with p340(RanBP2) in Xenopus extracts. These results suggest Ubc9p's role in cell cycle regulation may involve either modification of nuclear transport substrates or the nuclear transport machinery.
Controllable Patterning of Different Cells Via Optical Assembly of 1D Periodic Cell Structures (2015)

Flexible patterning of different cells into designated locations with direct cell–cell contact at single‐cell patterning precision and control is of great importance, however challenging, for cell patterning. Here, an optical assembly method for patterning of different types of cells via direct cell–cell contact at single‐cell patterning precision and control is demonstrated. Using Escherichia coli and Chlorella cells as examples, different cells are flexibly patterned into 1D periodic cell structures (PCSs) with controllable configurations and lengths, by periodically connecting one type of cells with another by optical force. The patterned PCSs can be flexibly moved and show good light propagation ability. The propagating light signals can be detected in real‐time, providing new opportunities for the detection of transduction signals among patterned cells. This patterning method is also applicable for cells of other kinds, including mammalian/human cells.
Eine modulare Funktionsarchitektur für adaptives und vorausschauendes Energiemanagement in Hybridfahrzeugen (2010)

Aufgrund des relativ niedrigen Energieinhalts von elektrischen Energiespeichern unterliegt die Betriebsstrategie von Hybridfahrzeugen einem Zielkonflikt. Einerseits muss sie ausreichend Energie für die elektrische Antriebsunterstützung oder das rein elektrische Fahren bereithalten, andererseits muss der Ladezustand zur Rekuperation von Energie ausreichend niedrig gehalten werden. Die Arbeit stellt Methoden zur energetischen Interpretation der vorausliegenden Fahrstrecke vor, die auf Informationen von Fahrerassistenzsystemen zurückgreifen. Es wird ein modulares Gerüst aus Funktionen vorgestellt, die den Energiehaushalt des Fahrzeugs je nach vorhergesehenem Energiebedarf prädiktiv einstellen. Die Verbrauchs- und Fahrleistungspotenziale der Funktionsarchitektur werden simulationsgestützt ermittelt, während der reale Funktionsnachweis durch die Implementierung der vorausschauenden Betriebsstrategie in ein Versuchsfahrzeug erbracht wird.
Enhancement of molecular fluorescence and photochemistry by small metal particles (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnhancement of molecular fluorescence and photochemistry by small metal particlesPurna Das and Horia MetiuCite this: J. Phys. Chem. 1985, 89, 22, 4680–4687Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/j100268a007https://doi.org/10.1021/j100268a007research-articleACS PublicationsRequest reuse permissionsArticle Views442Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The devil and packet trace anonymization (2006)

Releasing network measurement data---including packet traces---to the research community is a virtuous activity that promotes solid research. However, in practice, releasing anonymized packet traces for public use entails many more vexing considerations than just the usual notion of how to scramble IP addresses to preserve privacy. Publishing traces requires carefully balancing the security needs of the organization providing the trace with the research usefulness of the anonymized trace. In this paper we recount our experiences in (i) securing permission from a large site to release packet header traces of the site's internal traffic, (ii) implementing the corresponding anonymization policy, and (iii) validating its correctness. We present a general tool, tcpmkpub, for anonymizing traces, discuss the process used to determine the particular anonymization policy, and describe the use of metadata accompanying the traces to provide insight into features that have been obfuscated by anonymization
Production of Human Monoclonal Antibodies Specific for Conformational and Linear Non-V3 Epitopes of gp120 (1992)

Three IgG1 human monoclonal antibodies (MAbs) directed against conformational epitopes of the gp120 envelope protein of HIV-1 were produced, as was a single human MAb to a linear epitope spanning amino acids 487-509 in the C-terminal portion of gp120. All three conformation-dependent MAbs reacted optimally with recombinant gp120 (rgp120) captured on plastic via its carbohydrate moieties with Concanavalin A. These MAbs were able to block the interaction between recombinant CD4 (rCD4) and rgp120; they were also able to achieve 50% neutralization of HTLV-IIIB and MN strains of HIV-1 in a concentration range of 0.5-12.8 micrograms/mL. The MAb to the linear determinant is the first reported human MAb specific for the immunodominant portion of gp120; this MAb was most reactive with rgp120 when it was coated directly on plastic. It could neither inhibit rCD4-rgp120 binding nor neutralize either HTLV-IIIB or MN. The binding affinities of the four human MAbs for rgp120 in solution, reflected by their dissociation constants (Kd), ranged from 0.5 x 10(-8) to 7.5 x 10(-8) M.
Microsoft Outlook 2000 Bible with Cdrom (1999)

From the Publisher:
If Outlook 2000 can do it, you can do it too Microsoft® Outlook® 2000 Bible is your all-in-one reference for mastering Outlook 2000, Microsoft's popular messaging and groupware application. Practical examples and advice help you maximize Outlook's integrated e-mail, calendar, contact management, task tracking, and online synchronization features  and let you take advantage of new additions such as the contact activity tracker and the smart meeting planner. Packed with step-by-step instructions for creating groupware applications, Microsoft Outlook 2000 Bible delivers all you need to become an Outlook power user. Inside, you'll find complete coverage of Outlook 2000
*Get up to speed on new features like the contact activity tracker and Web-publishable calendars
*Quickly and easily start using Outlook to make appointments, schedule tasks, plan meetings, and more
*Synchronize Outlook with remote locations over the Internet
*Install and use Com add-ins to make Outlook even more powerful
*Customize your e-mail and calendar settings to fit the way you work
*Learn how to develop groupware applications easily with VBScript and the Outlook Object ModelCD-ROM packed with content and software to help you get more out of Microsoft Outlook 2000
*Examples demonstrating the use of forms, controls, custom fields, and more
*Searchable Adobe PDF files of the entire book
*Adobe Acrobat Reader
*Microsoft Internet ExplorerShareware programs are fully functional, free trial versions of copyrighted programs. If you like particular programs, register with their authors for a nominal fee and receive licenses, enhancedversions, and technical support. Freeware programs are free, copyrighted games, applications, and utilities. You can copy them to as many PCs as you likefreebut they have no technical support. System Requirements: PC running Windows 95/98/NT, 16MB RAM, 58MB hard disk space
Open-circuit voltage limit caused by recombination through tail states in bulk heterojunction polymer-fullerene solar cells (2010)

The output open-circuit voltage of bulk heterojuntion polymer-fullerene solar cells exhibts an offset of Δ≈0.3 V with the difference between the donor highest-occupied molecular orbital (HOMO) and the acceptor lowest-unoccupied molecular orbital (LUMO), as discussed by Scharber et al. [Adv. Mater. (Weinheim, Ger.) 18, 789 (2006)]. We show that the energetic disorder of the electronic density-of-states (DOS) of acceptor and donor materials reduces the splitting of the electron and hole Fermi levels in bulk heterojunction solar cells, by restricting the accumulation of carriers into the tails of the DOS. A simple model based on the kinetic balance between photogeneration and recombination fluxes provides a lower limit to the energy offset Δ&gt;(σn2+σp2)/kBT in terms of the disorder parameters.
Efficient mining of association rules in distributed databases (1996)

Many sequential algorithms have been proposed for the mining of association rules. However, very little work has been done in mining association rules in distributed databases. A direct application of sequential algorithms to distributed databases is not effective, because it requires a large amount of communication overhead. In this study, an efficient algorithm called DMA (Distributed Mining of Association rules), is proposed. It generates a small number of candidate sets and requires only O(n) messages for support-count exchange for each candidate set, where n is the number of sites in a distributed database. The algorithm has been implemented on an experimental testbed, and its performance is studied. The results show that DMA has superior performance, when compared with the direct application of a popular sequential algorithm, in distributed databases.
Omega-3 Fatty Acids and Cardiovascular Disease: New Developments and Applications (2013)

The omega-3 fatty acids (FA) found in fish oils, eicosapentaenoic and docosahexaenoic acids (EPA and DHA, respectively), have been extensively studied therapeutically in a wide variety of disease conditions, but in none more than cardiovascular disease (CVD). Our review summarizes mechanisms of action, recent meta-analyses of CVD outcome trials, sources (fish and supplements), and recommendations for use of omega-3 FA in clinical practice. With the ability to now measure the omega-3 FA biostatus through blood tests, patients can achieve cardioprotective levels by either taking fish oil supplements or simply eating more oily fish. Two omega-3 FA formulations (both in the ethyl ester form) have been approved by the US Food and Drug Administration (FDA) for the treatment of patients with very high triglyceride levels (> 500 mg/dL); one contains both EPA and DELA, whereas the other contains only EPA. The agents have been extensively tested in 2 patient populations, those with very high triglycerides and those with triglycerides between 200 and 500 mg/dL while on background statin therapy. In general, treatment with EPA+DHA appears to lower patient triglycerides more effectively, but in those patients with very high triglyceride levels, use of EPA+DHA also raised low-density lipoprotein cholesterol levels, whereas EPA alone did not. Both formulations, at doses that do not lower triglycerides, have been shown to reduce CVD events in some, but not all, studies. Given the favorable risk-to-benefit ratio for these essentially nutritional agents, use is expected to continue to expand.
In vitro fermentation of potential prebiotic flours from natural sources: Impact on the human colonic microbiota and metabolome (2012)

Our findings support the utilization of the tested ingredients in the development of a variety of potentially prebiotic food products aimed at improving gastrointestinal health.
Net-To-Gross Ratios: Implications in Integrated Reservoir Management Studies (2005)

Abstract Geoscientists and reservoir engineers are very well acquainted with the terms "net-to-gross (NTG)" and "petrophysical cut-offs" or just "cut-offs". The significance of these terms is ultimately to define productive zones in the reservoir for hydrocarbon exploitation. However, there has been marked misunderstanding surrounding the usage of the term, net-to-gross and implicitly, the derivation of cut-offs which are limiting values used in expressing the net-to-gross ratio. While the geologist may be concerned with the pay for evaluating hydrocarbon-in-place and the ultimately the estimation of economically producible reserves, the simulation engineer is more concerned with fluid flow for pressure support in the reservoir1. The significance of this paper is to consider the different cut-offs selection methods, the varying interpretation of net-to-gross ratios and the implications inherent in such methods. A case study from a field in the Niger Delta is also carried out to reveal the impact of such selection criteria especially in rocks with congenital weak hydraulic properties which cannot be excluded at geologic correlation stage2. The effect of cut-off parameters on oil-initially-in-place (OIIP) calculation was also investigated and a sensitivity analysis carried out on the petrophysical parameters to reveal the impact of the dynamically conditioned cut-offs selection on the petrofacies. Multiple Monte Carlo realizations were also employed to obtain probabilistic OIIP estimates rather than a single deterministic result.
miR‐33a‐5p modulates <scp>TNF</scp>‐α‐inhibited osteogenic differentiation by targeting <scp>SATB</scp>2 expression in h<scp>BMSC</scp>s (2016)

miRNAs play a number of roles in bone, including mediating the pathological effects of inflammation. Here, we found that miR-33a-5p expression was significantly increased after TNF-α treatment during BMP-2-induced osteogenic differentiation of hBMSCs. Luciferase reporter assays and western blotting demonstrated that special AT-rich sequence-binding protein 2 (SATB2) is a target of miR-33a-5p. Moreover, we show that BMP-2 induces SATB2 expression by interacting with SATB2 directly via the BMP-2-RUNX2 pathway. However, TNF-α first decreases SATB2 expression by inhibiting miR-33a-5p degradation. We thus conclude that miR-33a-5p plays a central role in this complex regulatory network. These findings will help to understand the regulatory role of miR-33a-5p in the inflammatory process.