gebhart/patrepeval huggingface dataset:
Forensic detection of image manipulation using statistical intrinsic fingerprints (2010)

As the use of digital images has increased, so has the means and the incentive to create digital image forgeries. Accordingly, there is a great need for digital image forensic techniques capable of detecting image alterations and forged images. A number of image processing operations, such as histogram equalization or gamma correction, are equivalent to pixel value mappings. In this paper, we show that pixel value mappings leave behind statistical traces, which we shall refer to as a mapping's intrinsic fingerprint, in an image's pixel value histogram. We then propose forensic methods for detecting general forms globally and locally applied contrast enhancement as well as a method for identifying the use of histogram equalization by searching for the identifying features of each operation's intrinsic fingerprint. Additionally, we propose a method to detect the global addition of noise to a previously JPEG-compressed image by observing that the intrinsic fingerprint of a specific mapping will be altered if it is applied to an image's pixel values after the addition of noise. Through a number of simulations, we test the efficacy of each proposed forensic technique. Our simulation results show that aside from exceptional cases, all of our detection methods are able to correctly detect the use of their designated image processing operation with a probability of 99% given a false alarm probability of 7% or less.
Post-processing of clock trees via wiresizing and buffering for robust design (1996)

Achieving near-zero skew for a large clock tree is generally at the expense of adding large amounts of metal interconnect. This added metal can significantly increase the total clock-net capacitance, thereby increasing the power dissipation in proportion. In addition, it is shown that it becomes increasingly difficult to control clock-signal skew due to metal-wiring process variations as the total clock-net capacitance increases. In this paper we demonstrate that buffer insertion can be used to reduce the total capacitance, hence the power, while generating a design which is as robust as one with no intermediate buffering. Moreover, delays are reduced substantially as well. Given an initial feasible route with constraints. On wire widths, wire sizing and buffer insertion are performed concurrently at each iteration of optimal buffer location search. Statistical process variations of the buffers, their loads, and the metal interconnect parameters are considered as part of the robust design process.
Replication of association of <i>DENND1A</i> and <i>THADA</i> variants with polycystic ovary syndrome in European cohorts (2011)

At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations, and are therefore likely to be important in the aetiology of PCOS regardless of ethnicity. The analysis of the LHCGR gene was not sufficiently powered to detect modest effects.
Transparent conductive graphene textile fibers (2015)

Transparent and flexible electrodes are widely used on a variety of substrates such as plastics and glass. Yet, to date, transparent electrodes on a textile substrate have not been explored. The exceptional electrical, mechanical and optical properties of monolayer graphene make it highly attractive as a transparent electrode for applications in wearable electronics. Here, we report the transfer of monolayer graphene, grown by chemical vapor deposition on copper foil, to fibers commonly used by the textile industry. The graphene-coated fibers have a sheet resistance as low as ~1 kΩ per square, an equivalent value to the one obtained by the same transfer process onto a Si substrate, with a reduction of only 2.3 per cent in optical transparency while keeping high stability under mechanical stress. With this approach, we successfully achieved the first example of a textile electrode, flexible and truly embedded in a yarn.
Efecto de altas presiones en esporas de Bacillus cereus en carne de vacuno (2003)

Se estudió el efecto del tratamiento a alta presión (HPP) solo y en combinación con la nisina sobre esporas de Bacillus cereus en carne de vacuno. La presión en un intervalo de 0 a 800 MPa por sí misma, como en combinación con nisina (670 IU g-1), fue estudiada en carne molida envasada al vacío. Las esporas de Bacillus cereus (inoculación artificial) fueron muy resistentes (D10 = 800 MPa) al tratamiento hidrostático. El estudio de la eficacia del tratamiento HPP en combinación con la nisina requiere más trabajo de investigación.
Cloning and Expression of a New Structural Gene for Blasticidin S Deaminase, a Nucleoside Aminohydrolase (1987)

Journal Article Cloning and Expression of a New Structural Gene for Blasticidin S Deaminase, a Nucleoside Aminohydrolase Get access Takashi Kamakura, Takashi Kamakura The Institute of Physical and Chemical Research, 2–1 Hirosawa, Wako-shi, Saitama 351–01, Japan Search for other works by this author on: Oxford Academic Google Scholar Kaori Kobayashi, Kaori Kobayashi Kyoritsu College of Pharmacy, 1–5–30 Shiba-koen, Minato-ku, Tokyo 105, Japan Search for other works by this author on: Oxford Academic Google Scholar Teruo Tanaka, Teruo Tanaka Mitsubishi-kasei Institute of Life Science, 11 Minami-ohya, Machida-shi, Tokyo 197, Japan Search for other works by this author on: Oxford Academic Google Scholar Isamu Yamaguchi, Isamu Yamaguchi The Institute of Physical and Chemical Research, 2–1 Hirosawa, Wako-shi, Saitama 351–01, Japan Search for other works by this author on: Oxford Academic Google Scholar Toyoshige Endō Toyoshige Endō Kyoritsu College of Pharmacy, 1–5–30 Shiba-koen, Minato-ku, Tokyo 105, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 51, Issue 11, 1 November 1987, Pages 3165–3168, https://doi.org/10.1080/00021369.1987.10868511 Published: 01 November 1987 Article history Received: 10 August 1987 Published: 01 November 1987
Comparative study of the antitumor activity of free doxorubicin and polyethylene glycol-coated liposomal doxorubicin in a mouse lymphoma model. (1998)

Here, we investigate various factors affecting the therapeutic efficacy of free doxorubicin (Free-Dox) and polyethylene glycol (PEG)-coated (PEGylated) liposomal doxorubicin (referred to as Doxil) in the ascitic J6456 lymphoma model of BALB/c mice. Free drug and liposomal drug were affected differently by the tumor burden and route of treatment administration. A delay in start of treatment from day 1 to day 5 almost completely abolished the efficacy of Free-Dox, whereas that of Doxil was only minimally reduced. Contrasting effects on the therapeutic efficacy of Free-Dox and Doxil were obtained by changing treatment administration from the i.v. to the i.p. route; the efficacy of free drug was relatively enhanced, whereas that of liposomal drug was relatively diminished. Overall, Doxil given by the systemic i.v. route was the most effective treatment in prolonging median survival and obtaining cures. Variations in the dose-schedule treatment regime confirm the superior therapeutic profile and reduced dependence on tumor burden of the PEGylated liposomal formulation over free drug. In addition, these experiments indicate that, at equal dose intensity, the dose level is more important than the frequency of administration for therapeutic activity.
The rock and roll years (2003)

This study piloted a brief individual motivational intervention targeting multiple health risk behaviors in HIV-positive youth aged 16-25. Interviews about sexual behavior and substance use and viral load testing were obtained from 51 HIV-positive youth at baseline and post intervention. Youth were randomized to receive a four-session motivational enhancement intervention (N = 25) or to a wait-list control (N = 26). Of the eligible youth approached, 88% agreed to participate, and 80% percent of participants completed at least three of four sessions. The treatment group showed significantly greater reductions in unprotected sex acts and in viral load compared with controls. Although change scores for substance use were not significantly different between the two groups, paired t tests demonstrated that reductions in alcohol use and marijuana use were significant for the treatment group at the trend level. There were no significant differences in substance use from baseline to posttest for the control group. Findings demonstrate the potential of a brief motivational enhancement intervention to improve health risk behaviors in HIV-positive youth. Larger randomized clinical trials are warranted. Resources required for retention should not be underestimated.
Three-dimensional applications in orthodontics (2019)

Orthodontics as a specialty is going through a technological revolution. During the last 10 years there were more new developments in orthodontics than in the whole history of the specialty. One of the areas undergoing rapid progress is three-dimensional (3D) imaging. 3D Imaging allows for more precise evaluation of the airway. Patients displaying a Skeletal Class II had smaller airway volume while controlling for age, gender and size of face. The shape of the airway was different among individual with different antero-posterior jaw relationship. Airway volume among patients with different vertical jaw relationship displayed great variability. A good understanding of imaging concepts is important for the contemporary clinician. Most of the three-dimensional visual information is not liked yet to a clear diagnosis and prognosis classification. Visualization, measurement, creation of two-dimensional (2D) radiographs, segmentation, registration, superimposition and other quantitative analysis require specific training and specialized software in order to manipulate 3D files. In order to compare the newer 3D images with our current and historical databases, it is necessary to emulate 2D radiographs from 3D data. When we compared homologous landmark coordinates in digital and synthetic cephalograms, there was no systematic error. However when both modalities are used in the same individual the error of the method could produce clinically significant differences. A second area undergoing rapid progress is orthodontic digital models. These are qualitatively and quantitatively similar to conventional dental casts, but offer some advantages. One of these advantages is the possibility of register and superimpose them in space. The registration of digital orthodontic models to represent the patients' occlusion, as well as registration of final orthodontic models to the planned setup models was reliable. Finally, CAD/CAM technology allows for fabricating orthodontic appliances on a setup model of the planned correction. Based on a three-dimensional comparison of the planned tooth positions with the final ones, A fully customized lingual technique was very accurate in achieving the planned tooth positions in terms of translation and rotation. Digital orthodontics and digital dentistry have arrived: be part of it
High-Performance Distributed RMA Locks (2016)

We propose a topology-aware distributed Reader-Writer lock that accelerates irregular workloads for supercomputers and data centers. The core idea behind the lock is a modular design that is an interplay of three distributed data structures: a counter of readers/writers in the critical section, a set of queues for ordering writers waiting for the lock, and a tree that binds all the queues and synchronizes writers with readers. Each structure is associated with a parameter for favoring either readers or writers, enabling adjustable performance that can be viewed as a point in a three dimensional parameter space. We also develop a distributed topology-aware MCS lock that is a building block of the above design and improves state-of-the-art MPI implementations. Both schemes use non-blocking Remote Memory Access (RMA) techniques for highest performance and scalability. We evaluate our schemes on a Cray XC30 and illustrate that they outperform state-of-the-art MPI-3 RMA locking protocols by 81% and 73%, respectively. Finally, we use them to accelerate a distributed hashtable that represents irregular workloads such as key-value stores or graph processing.
Multi-objective Middleware for Distributed VMI Repositories in Federated Cloud Environment (2016)

Virtualization represents an essential technology in Cloud computing, which allows virtual machines (VM) to be executed within their own environment on top of physical hardware. The modern methods for software delivery are utilizing the concept of Vitual Machine as a efficient tool for software packaging. Typically, VMs are created using specific templates that are stored in proprietary repositories, thus leading to provider lock-in and reduced portability in the cases of simultaneous usage of multiple federated Clouds. Unfortunately, the current state-of-the-art does not provide any efficient means for streamlined management of VM images across multiple repositories, especially within federated Cloud environments. In this paper we present a novel multi-objective middleware for distributed VMI repositories in federated Cloud environment. The middleware has been designed to provide easy to use interface capable of receiving unmodified and functionally complete VM images from its users, and transparently distribute them to a specific Cloud infrastructure in a federation with respect to their size, configuration, and geographical distribution, such that they are loaded, delivered, and executed faster and with improved QoS compared to their current behaviour.
Synthesis and Biological Evaluation of RGD-Conjugated MEK1/2 Kinase Inhibitors for Integrin-Targeted Cancer Therapy (2013)

Two novel series of RGD-MEKI conjugates derived from a MEK1/2 kinase inhibitor--PD0325901--have been developed for integrin receptor mediated anticancer therapy. The first series, alkoxylamine analog RGD-MEKI conjugates 9a-g showed anti-proliferation activity in melanoma A375 cells by the same mechanism as that of PD0325901. PEGylation increased the IC50 value of 9f three-fold in the A375 assay, and the multi-cRGD peptide cargo significantly improved the receptor specific anti-proliferation activity of 9g in integrin-overexpressing U87 cells. In the second series, RGD-PD0325901 13 exhibited significantly increased antitumor properties compared to the alkoxylamine analogs by both inhibition of the ERK pathway activity and DNA replication of the cancer cells. Furthermore, 13 displayed more potent anti-proliferation activity in the U87 assay than PD0325901 in a dose-dependent manner. All these data demonstrate that RGD-MEKI conjugates with an ester bond linkage enhanced anticancer efficacy with improved targeting capability toward integrin-overexpressing tumor cells.
A Mixed Decorrelation Approach for Stereo Acoustic Echo Cancellation Based on the Estimation of the Fundamental Frequency (2011)

In teleconferencing systems, undesired echoes due to coupling between the loudspeaker and the microphone can be reduced using acoustic echo cancellers (AECs). In order to introduce better performance in terms of sound localization, at least stereophonic AECs (SAECs) have to be employed. In this case, the correlation between the two channels prevents a correct identification of the echo paths and a signal decorrelation is needed. In this paper, a novel mixed approach to signal decorrelation is proposed based on the estimation of the fundamental frequency. The principle of the proposed structure is to use an approach based on the “missing-fundamental” phenomenon at low frequencies (below 500 Hz), a time-varying all-pass filter controlled by the fundamental frequency at medium and high frequencies, and a time-varying multi-notch filter for improving performance in the upper part of the spectrum. Experiments confirm the effectiveness of the proposed approach in terms of correct identification of the echo paths and stereo perception preservation.
Management of Children With Autism Spectrum Disorders (2014)

New!Keep up with current practice guidelines and policies with the latest, most up-to-date edition of this clinical reference classic. This evidence-based decision-making tool for managing common pediatric conditions has been revised and updated for 2014, with the latest clinical practice guidelines for more than 30 conditions, plus every AAP policy statement, clinical report, and technical report through December 2013.Updated and expanded for 2014 including:- Three new AAP clinical practice guidelines- Management of Newly Diagnosed Type 2 Diabetes Mellitus- Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years- Diagnosis and Management of Acute Otitis Media- New Periodicity Schedule- Full text of more than 60 new or revised AAP policies- CD-ROM includes the full text of more than 400 AAP clinical practice guidelines, policy statements, clinical reports, and technical reports.- More than 30 clinical practice guidelines including Sleep Apnea, ADHD, bronchiolitis, dysplasia of the hip, gastroenteritis, otitis media, urinary tract infection and more.- 2014 immunization schedule.
Peak Height Pattern in Dichloro-Rhodamine and Energy Transfer Dye Terminator Sequencing (1998)

Establishing the pattern in peak heights within local sequence contexts improves the accuracy of base calling and the identification of DNA sequence variations in dye-terminator cycle sequencing. We have systematically examined pairs of sequence-tagged sites (STSs) that vary at only a single nucleotide to determine how base changes influence the peak heights of neighboring bases in sequencing traces generated by two recently commercialized dye-terminator chemistries, the dichloro-rhodamine (dRhodamine) and the energy transfer (BigDye) terminators. For sequencing traces generated with the dRhodamine terminators, the peak height of a particular base in 28 of 64 possible 3-base windows (44%) can be predicted by knowing just one or two bases 5' to the base in question. For those generated with the BigDye terminators, the peak height of a particular base in 23 of 64 possible 3-base windows (36%) can be predicted by knowing the local sequence context. When the peak heights are binned slightly differently, 75% (48 out of 64 cases) of the base peaks generated by both dRhodamine and BigDye terminators fall in the middle half, confirming that the peak patterns of these two new dye terminator chemistries are much more even than those found in the original rhodamine dye terminator sequences.
Daptomycin Nonsusceptible Enterococci: An Emerging Challenge for Clinicians (2010)

Daptomycin is the only antibiotic with in vitro bactericidal activity against vancomycin-resistant Enterococcus (VRE) that is approved by the Food and Drug Administration (FDA). Data on the potential emergence of daptomycin nonsusceptibility among enterococci remain limited. We systematically reviewed the published literature for reports of isolates of enterococci that were daptomycin nonsusceptible and assessed the clinical significance and outcome of therapy. Based on susceptibility breakpoints approved by the Clinical Laboratory Standards Institute (CLSI), daptomycin has in vitro activity against >90% of enterococcal isolates. Less than 2% of enterococcal isolates were daptomycin nonsusceptible, with minimum inhibitory concentrations (MICs) >4 μg/mL. The prevalence of nonsusceptibility of VRE isolates to daptomycin may be overestimated due to the spread of clonally related isolates in health care settings. Clinicians should be aware of the possibility of the emergence of daptomycin nonsusceptibility and should closely monitor daptomycin MICs of enterococci isolated during treatment.
The capacity of PCM voiceband channels (2002)

It is theoretically shown that the capacity of a voiceband channel operating through a digital network is at least 56 kbps (for a 3.5 kHz baseband bandwidth). The capacity may actually be higher but how close one can come to 64 kbps, the limit imposed by the digital network itself, is unknown. The transmission method is based on generating nonuniformly pulsed PAM (pulse amplitude modulation) signals which at the network sampling instants go through one of the slicing levels of the A/D converter of the network. To accomplish this, both the slicing levels and the sampling clock times must be known. This is a hard practical problem and one can only conjecture if a reasonable solution will be possible. The signal may be recovered using a Viterbi detector to reduce intersymbol interference effects, but at present, the number of states required for this detector is very large.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Adsorbent from Rice Husk for CO<sub>2</sub> Capture: Synthesis, Characterization, and Optimization of Parameters (2018)

In the present work, adsorbents were prepared from rice husk in order to capture CO2 from a flue gas stream. Various pretreatment processes such as desilicalization, chemical activation, and K2CO3 impregnation were followed to prepare the adsorbents. The physico-chemical characterization of the adsorbents was performed in detail in an elaborated way. A fixed-bed reactor was used to measure the CO2 capture capacity of the in-house developed adsorbents. The effect of various process parameters such as adsorption temperature, moisture content, and loading of active component on CO2 adsorption capacity was studied, and results were compared with a commercially available activated carbon. The maximum adsorption capacity observed for 20K-ARH adsorbent was as high as 67 g of CO2/kg sorbent. The effect of water on CO2 adsorption was critically examined, and formation of KHCO3 was observed in the presence of water during the adsorption process. The optimum operating conditions for the maximum removal of CO2 from a simulated flue gas include a temperature range of 30–40 °C, relative humidity range of 80–90%, and K2CO3 loading of about 20 wt %. It was observed that around 94% of the adsorbed CO2 can be desorbed at 180 °C, and the adsorbent can be reused for multiple cycles without compromising the capture capacity significantly.