gebhart/patrepeval huggingface dataset:
Carnosine interaction with nitric oxide and astroglial cell protection (2007)

The neuropeptide carnosine (beta-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFgamma), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and beta-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders.
Synthesis of fluorinated maltose derivatives for monitoring protein interaction by <sup>19</sup>F NMR (2012)

A novel reporter system, which is applicable to the (19)F NMR investigation of protein interactions, is presented. This approach uses 2-F-labeled maltose as a spy ligand to indirectly probe protein-ligand or protein-protein interactions of proteins fused or tagged to the maltose-binding protein (MBP). The key feature is the simultaneous NMR observation of both (19)F NMR signals of gluco/manno-type-2-F-maltose-isomers; one isomer (α-gluco-type) binds to MBP and senses the protein interaction, and the nonbinding isomers (β-gluco- and/or α/β-manno-type) are utilized as internal references. Moreover, this reporter system was used for relative affinity studies of fluorinated and nonfluorinated carbohydrates to the maltose-binding protein, which were found to be in perfect agreement with published X-ray data. The results of the NMR competition experiments together with the established correlation between (19)F chemical shift data and molecular interaction patterns, suggest valuable applications for studies of protein-ligand interaction interfaces.
Estrogen receptors in prostate development and cancer. (2014)

Prostate cancer (PCa) is an androgen-sensitive disease, which can be pharmacologically controlled by androgen blockade. To date, a growing body of evidence showed that estrogen and estrogen receptors (ERs) could regulate prostate development, as well as cancer initiation and progression. This review will address the expression levels and function of ERs in different stages of PCa progression. The functions of ERs in different types of prostate cells, the ligand effect, and the potential applications of selective estrogen modulators (SERMs) will also be discussed. To further dissect ERs' roles in prostate development, cell type specific ER knockout mouse models were generated. Results collected from the prostate cell type-specific ERαKO mouse models provided new insights about the cell type specific ERα roles in prostate development prenatally and postnatally. The results of ERs' roles in mouse PCa mode and the correlation of ERs expression and biomedical outcome will also be discussed.
The cooperative international neuromuscular research group Duchenne natural history study: Glucocorticoid treatment preserves clinically meaningful functional milestones and reduces rate of disease progression as measured by manual muscle testing and other commonly used clinical trial outcome measures (2013)

In DMD, long-term use of GCs showed reduced strength loss and preserved functional capabilities and PFTs compared with previous natural history studies performed prior to the widespread use of GC therapy.
Designing for innovation around OER (2010)

This paper argues that designing collections of ‘closed’ educational resources (content and technologies) for use by specific student cohorts and collections of open educational resources for use by any ‘learner’ require different design approaches. Learning design for formal courses has been a research topic for over 10 years as the ever growing range of digital content and technologies has potentially offered new opportunities for constructing effective learning experiences, primarily through greater sharing and re-use of such content and technologies. While progress in adopting learning design by teaching practitioners has appeared slow so far, the advent of open educational resources (OER) has provided a substantive boost to such sharing activity and a subsequent need for employing learning design in practice. Nevertheless there appears to be a paradox in that learning design assumes a reasonably well known and well defined student audience with presumed learning needs and mediating technologies while OER are exposed to a multitude of potential learners, both formal and informal, with unknown learning needs and using diverse technologies. It can be argued that innovative designs for formal courses involve creating structured pathways through a mixture of existing and new content and activities using a mixture of media and technologies in the process. This type of ‘configurational’ design that blends together given items to meet a particular need, rather than designing something fully de novo is typical in many areas of work and not just teaching. Such designs work very well when there is a small set of users of the innovation or their use of the innovation is narrow. However many innovations in information, communication and computing technologies often have multiple types of users and many more layers of complexity. In these cases, rather than heavily pre-define an innovative solution just to meet certain user requirements, it is necessary to design for greater flexibility so as to allow the users to adapt their use of the innovative solution for their own requirements once it has been deployed. The use of such an ‘innofusion’ approach for OER is highlighted using the case study of OpenLearn (<a href="http://www.open.ac.uk/openlearn)">www.open.ac.uk/openlearn)</a>.
Pulmonary hypertension due to left heart disease (2018)

Pulmonary hypertension (PH) is frequent in left heart disease (LHD), as a consequence of the underlying condition. Significant advances have occurred over the past 5 years since the 5th World Symposium on Pulmonary Hypertension in 2013, leading to a better understanding of PH-LHD, challenges and gaps in evidence. PH in heart failure with preserved ejection fraction represents the most complex situation, as it may be misdiagnosed with group 1 PH. Based on the latest evidence, we propose a new haemodynamic definition for PH due to LHD and a three-step pragmatic approach to differential diagnosis. This includes the identification of a specific "left heart" phenotype and a non-invasive probability of PH-LHD. Invasive confirmation of PH-LHD is based on the accurate measurement of pulmonary arterial wedge pressure and, in patients with high probability, provocative testing to clarify the diagnosis. Finally, recent clinical trials did not demonstrate a benefit in treating PH due to LHD with pulmonary arterial hypertension-approved therapies.
Mismatch DNA Recognition Protein from an Extremely Thermophilic Bacterium, Thermus Thermophilus HB8 (1996)

The mutS gene, implicated in DNA mismatch repair, was cloned from an extremely thermophilic bacterium, Thermus thermophilus HB8. Its nucleotide sequence encoded a 819-amino acid protein with a molecular mass of 91.4 kDa. Its predicted amino acid sequence showed 56 and 39% homology with Escherichia coli MutS and human hMsh2 proteins, respectively. The T.thermophilus mutS gene complemented the hypermutability of the E.coli mutS mutant, suggesting that T.thermophilus MutS protein was active in E.coli and could interact with E.coli MutL and/or MutH proteins. The T.thermophilus mutS gene product was overproduced in E.coli and then purified to homogeneity. Its molecular mass was estimated to be 91 kDa by SDS-PAGE but approx. 330 kDa by size-exclusion chromatography, suggesting that T.thermophilus MutS protein was a tetramer in its native state. Circular dichroic measurements indicated that this protein had an alpha-helical content of approx. 50%, and that it was stable between pH 1.5 and 12 at 25 degree C and was stable up to 80 degree C at neutral pH. Thermus thermophilus MutS protein hydrolyzed ATP to ADP and Pi, and its activity was maximal at 80 degrees C. The kinetic parameters of the ATPase activity at 65 degrees C were Km = 130 microM and Kcat = 0.11 s(-1). Thermus thermophilus MutS protein bound specifically with G-T mismatched DNA even at 60 degrees C.
Inhibition of cytokine-induced expression of T-cell cytokines by antihistamines. (2007)

RT-PCR revealed that IL-12-induced expression of IFN-gamma was partially suppressed by loratadine and fexofenadine and that all 4 agents tested inhibited IL-4-induced expression of IL-5. ELISA demonstrated that IL-12-induced IFN-gamma production was significantly suppressed by cetirizine and fexofenadine and IL-4-induced IL-5 production was downregulated by three agents with the exception of cetirizine. This study demonstrates that antihistamines have varying immunomodulatory properties, suggesting treatment choice for atopic dermatitis can be directed by disease signs and symptoms.
Clinical study of a pre-brush rinse and a triclosan/copolymer mouthrinse: effect on plaque formation. (1990)

A 6-day, double-blind parallel clinical study was conducted to determine the effect on plaque formation of a mouthrinse containing 0.03% triclosan (Irgacare MP) and 0.25% of a copolymer of methoxyethylene and maleic acid (Gantrez), as compared to a flavored/colored water placebo mouthrinse and Plax antiplaque pre-brushing dental rinse. A total of 60 subjects were stratified into three balanced groups using their pre-prophylaxis Plaque Index score. All subjects received a thorough oral prophylaxis at the start of the study. Each group was randomly assigned to the use of either the water placebo mouthrinse, the Plax mouthrinse or the mouthrinse containing triclosan/copolymer. Subjects rinsed twice daily (mornings and evenings) for 1 minute with 15 cc of their assigned mouthrinse. Immediately after rinsing, subjects brushed their teeth for 30 seconds with a commercially available dentifrice containing 0.76% sodium monofluorophosphate in a silica base and a soft-bristled toothbrush. The morning rinsing/brushing procedure was performed under the supervision at the clinical facility. The evening rinsing/brushing procedure was conducted at home. After 5 days' use of their assigned mouthrinse, subjects were evaluated by the dental examiner for plaque formation. The results indicated that the triclosan/copolymer mouthrinse, when used as a pre-brush rinse prior to regular toothbrushing, provided statistically significant reductions in supragingival plaque formation, when compared to both a pre-brush water placebo mouthrinse (-39.83%) or Plax antiplaque prebrushing dental rinse (-37.30%).
The Fixed Combination of Acetylsalicylic acid, Paracetamol and Caffeine is more Effective than Single Substances and Dual Combination for the Treatment of Headache: a Multicentre, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Parallel Group Study (2005)

We investigated efficacy, safety, and tolerability of two tablets of the fixed combination of 250 mg acetylsalicylic acid (ASA) + 200 mg paracetamol + 50 mg caffeine (Thomapyrin) in comparison with two tablets of 250 mg ASA + 200 mg paracetamol, two tablets of 500 mg ASA, two tablets of 500 mg paracetamol, two tablets of 50 mg caffeine, and placebo in patients who were used to treating their episodic tension-type headache or migraine attacks with non-prescription analgesics. For the primary endpoint "time to 50% pain relief" in the intention-to-treat dataset (n = 1743 patients), the fixed combination of ASA, paracetamol and caffeine was statistically significantly superior to the combination without caffeine (P = 0.0181), the mono-substances ASA (P = 0.0398), paracetamol (P = 0.0016), caffeine (P < 0.0001) and placebo (P < 0.0001). All active treatments except caffeine differed significantly (P < 0.0001) from placebo. The superior efficacy of the triple combination could also be shown for all secondary endpoints such as time until reduction of pain intensity to 10 mm, weighted sum of pain intensity difference (%SPIDweighted), extent of impairment of daily activities, global assessment of efficacy. All treatments were well tolerated. The incidence of adverse events observed was low.
CHARSTAR (2017)

High-performance architectures are over-provisioned with resources to extract the maximum achievable performance out of applications. Two sources of avoidable power dissipation are the leakage power from underutilized resources, along with clock power from the clock hierarchy that feeds these resources. Most reconfiguration mechanisms either focus solely on power gating execution resources alone or in addition, simply turn off the immediate clock tree segment which supplied the clock to those resources. These proposals neither attempt to gate further up the clock hierarchy nor do they involve the clock hierarchy in influencing the reconfiguration decisions. The primary contribution of CHARSTAR is optimizing reconfiguration mechanisms to become clock hierarchy aware. Resource gating decisions are cognizant of the power consumed by each node in the clock hierarchy and additionally, entire branches of the clock tree are greedily shut down whenever possible.
SYMBOLIC-NUMERIC ESTIMATION OF PARAMETERS IN BIOCHEMICAL MODELS BY QUANTIFIER ELIMINATION (2006)

The sequencing of complete genomes allows analyses of the interactions between various biological molecules on a genomic scale, which prompted us to simulate the global behaviors of biological phenomena on the molecular level. One of the basic mathematical problems in the simulation is the parameter optimization in the kinetic model for complex dynamics, and many estimation methods have been designed. We introduce a new approach to estimate the parameters in biological kinetic models by quantifier elimination (QE), in combination with numerical simulation methods. The estimation method was applied to a model for the inhibition kinetics of HIV proteinase with ten parameters and nine variables, and attained the goodness of fit to 300 points of observed data with the same magnitude as that obtained by the previous estimation methods, remarkably by using only one or two points of data. Furthermore, the utilization of QE demonstrated the feasibility of the present method for elucidating the behavior of the parameters and the variables in the analyzed model. Therefore, the present symbolic-numeric method is a powerful approach to reveal the fundamental mechanisms of kinetic models, in addition to being a computational engine.
Bacteriophages for the treatment of Pseudomonas aeruginosa infections (2011)

Bacteriophages were first identified in 1915 and were used as antimicrobial agents from 1919 onwards. Despite apparent successes and widespread application, early users did not understand the nature of these agents and their efficacy remained controversial. As a result, they were replaced in the west by chemical antibiotics once these became available. However, bacteriophages remained a common therapeutic approach in parts of Eastern Europe where they are still in use. Increasing levels of antibiotic-resistant bacterial infections are now driving demand for novel therapeutic approaches. In cases where antibiotic options are limited or nonexistent, the pressure for new agents is greatest. One of the most prominent areas of concern is multidrug-resistant Gram-negative bacteria. Pseudomonas aeruginosa is a prominent member of this class and is the cause of damaging infections that can be resistant to successful treatment with conventional antibiotics. At the same time, it exhibits a number of properties that make it a suitable target for bacteriophage-based approaches, including growth in biofilms that can hydrolyse following phage infection. Pseudomonas aeruginosa provides a striking example of an infection where clinical need and the availability of a practical therapy coincide.
Ultrasonic plate waves in wood-based composite panels (2001)

Washington, Eric "Sneeze" Sniezak.To some degree
Process Analytical Chemistry (2001)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTProcess Analytical ChemistryJerome Workman,, Ken E. Creasy, Steve Doherty, Leonard Bond, Mel Koch, Alan Ullman, and David J. VeltkampView Author Information Analytical Science & Technology, Kimberly-Clark Corporation, Neenah, Wisconsin 54956, Process Analytical Chemistry Center, Honeywell Laboratories, Morristown, New Jersey 07962-1021, Chemical Sciences Group, Monsanto Company/Searle, Skokie, Illinois 60077, Pacific Northwest National Laboratory, Richland, Washington 99352, Center for Process Analytical Chemistry (CPAC), University of Washington, Seattle, Washington 98195-1700, and The Procter & Gamble Company, Center Hill Road, Cincinnati, Ohio 43224 Cite this: Anal. Chem. 2001, 73, 12, 2705–2718Publication Date (Web):May 2, 2001Publication History Published online2 May 2001Published inissue 1 June 2001https://pubs.acs.org/doi/10.1021/ac010364phttps://doi.org/10.1021/ac010364preview-articleACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1145Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemometrics,Materials,Raman spectroscopy,Sensors,Separation science Get e-Alerts
Alternative Type II NAD(P)H Dehydrogenases in the Mitochondria of Protists and Fungi (2018)

Plants, fungi, and some protists possess a more branched electron transport chain in their mitochondria compared to canonical one. In these organisms, the electron transport chain contains several rotenone-insensitive NAD(P)H dehydrogenases. Some are located on the outer surface, and others are located on the inner surface of the inner mitochondrial membrane. The putative role of these enzymes still remains elusive, but they may prevent the overreduction of the electron transport chain components and decrease the production of reaction oxygen species as a consequence. The last two decades resulted in the discovery of alternative rotenone-insensitive NAD(P)H dehydrogenases present in representatives of fungi and protozoa. The aim of this review is to gather and focus on current information concerning molecular and functional properties, regulation, and the physiological role of fungal and protozoan alternative NAD(P)H dehydrogenases.
Intramolecular Reactions of Alkynes with Furans and Electron Rich Arenes Catalyzed by PtCl<sub>2</sub>:  The Role of Platinum Carbenes as Intermediates (2003)

5-(2-Furyl)-1-alkynes react, with PtCl(2) as catalyst, to give phenols. On the basis of DFT calculations, a cyclopropyl platinacarbene complex was found as the key intermediate in the process. The cyclopropane and dihydrofuran rings of this intermediate open to form a carbonyl compound, which reacts with the platinum carbene to form an oxepin, which is in equilibrium with an arene oxide. When the reaction is carried out in the presence of water, dicarbonyl compounds are obtained, which support the proposed mechanism. Other cyclizations of alkynes with furans or electron-rich arenes give products of apparent Friedel-Crafts-type reactions, although these processes could also proceed by pathways involving the formation of cyclopropyl platinum carbenes.
Contact testing of copper micro-pillars with very low damage for 3D IC assembly (2013)

3D IC integration offers a new paradigm of system assembly, which enables further miniaturization and new architectures driven mostly by the next generation mobile electronics applications which require larger bandwidth, lower power consumption, smaller footprints and reduced cost. However, 3D integration presents test challenges and demands new test techniques. For the economic assembly of 3D stacks, high yield for each die needs to be assured before stacking. Even though the die are tested at wafer level with existing standard test techniques, during the wafer thinning, TSV formation and dicing, new defects may be introduced and these defects need to be caught before system assembly in order to achieve high yield. We present a highly scalable contactor solution, FormFactor Nanopierce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> , which can be used in both probe card configuration(wafer level test), or socket configuration (die level test) which enables testing individual bare die for a known good die (KGD) solution, and similarly, testing a subassembly of dies for a known good stack (KGS) solution before final system assembly. One of the concerns of direct testing of microbumps is the potential damage on the microbumps that may be caused during testing, which can compromise subsequent assembly steps. We demonstrate full area direct contact tests results on Copper micropillars at 40μmx50μm wide I/O pattern consisting of 1104 micropillars and demonstrate very low damage on Cu micropillars. This is enabled by the fact that Nanopierce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</sup> contactor relies on many small contact points within one contact pad and good electrical connection can be achieved at low contact forces with minimal surface damage. Contact force per spring is 0.5g at 15μm overtravel.
TwitterRank (2010)

This paper focuses on the problem of identifying influential users of micro-blogging services. Twitter, one of the most notable micro-blogging services, employs a social-networking model called "following", in which each user can choose who she wants to "follow" to receive tweets from without requiring the latter to give permission first. In a dataset prepared for this study, it is observed that (1) 72.4% of the users in Twitter follow more than 80% of their followers, and (2) 80.5% of the users have 80% of users they are following follow them back. Our study reveals that the presence of "reciprocity" can be explained by phenomenon of homophily. Based on this finding, TwitterRank, an extension of PageRank algorithm, is proposed to measure the influence of users in Twitter. TwitterRank measures the influence taking both the topical similarity between users and the link structure into account. Experimental results show that TwitterRank outperforms the one Twitter currently uses and other related algorithms, including the original PageRank and Topic-sensitive PageRank.