gebhart/patrepeval huggingface dataset:
The entrapment of mannose-terminated glucocerebrosidase (Alglucerase) in human carrier erythrocytes (1996)

Conference Article| August 01 1996 The entrapment of mannose-terminated glucocerebrosidase (Alglucerase) in human carrier erythrocytes BRIDGET E. BAX; BRIDGET E. BAX 1Paediatric Metabolism Unit, Department of Child Health, St George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar MURRAY D. BAIN; MURRAY D. BAIN 1Paediatric Metabolism Unit, Department of Child Health, St George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar CHANDRA P. WARD; CHANDRA P. WARD *The S.A.S. Laboratory for Genetic Enzyme Defects, Guy's Hospital, London, SE1 9RT Search for other works by this author on: This Site PubMed Google Scholar ANTHONY H. FENSOM; ANTHONY H. FENSOM *The S.A.S. Laboratory for Genetic Enzyme Defects, Guy's Hospital, London, SE1 9RT Search for other works by this author on: This Site PubMed Google Scholar RONALD A. CHALMERS RONALD A. CHALMERS 1Paediatric Metabolism Unit, Department of Child Health, St George's Hospital Medical School, London, SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (3): 441S. https://doi.org/10.1042/bst024441s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation BRIDGET E. BAX, MURRAY D. BAIN, CHANDRA P. WARD, ANTHONY H. FENSOM, RONALD A. CHALMERS; The entrapment of mannose-terminated glucocerebrosidase (Alglucerase) in human carrier erythrocytes. Biochem Soc Trans 1 August 1996; 24 (3): 441S. doi: https://doi.org/10.1042/bst024441s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: PBS, phosphate buffered saline This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Generation of electric energy by high-speed turbine-generator sets (2002)

In industrial plants and gas networks it is frequently required to reduce pressure of steam or gas to a lower value. The pressure reduction is carried out in most cases by using special pressure reducing valves. The process of pressure reduction is associated with loss of energy. The research work described is aimed at utilizing the waste energy of pressure reduction by converting the mechanical energy of the working fluid into electric energy that can be utilized directly or fed back to the utility mains. The system developed consists of a turbine, a generator, a three phase AC/AC converter and a supervisory control. As a result of special construction, the turbine is insensitive to pollution in the working medium, thus it can be applied in any steam or gas network where continuous pressure reduction is needed. The return time on the investment is relatively short particularly in countries with high cost of electric energy. Calculated average return time on investment depending mainly on the working time of the system is between 1.5 and 3 years assuming a 50 to 90% utilization.
Advanced Joint Transceiver Design for Block-Diagonal Geometric-Mean-Decomposition-Based Multiuser MIMO Systems (2009)

In this paper, we propose an advanced joint transceiver design for block-diagonal geometric-mean-decomposition (BD-GMD) based multiuser multiple-input-multiple-output (MIMO) systems. First, we use the lattice reduction (LR) method to design the BD-GMD-based advanced detection and precoding for an uplink and a downlink, respectively. Then, we exploit the vector perturbation (VP) technique to further improve the system performance of the multiuser downlink. To directly reduce the high complexity of VP by a sphere encoder, we provide an LR-based sphere encoder and LR-based approximations for perturbation symbols. Performance and complexity analyses are given to show the advantages of the proposed schemes. Particularly, the diversity-gain analysis shows some insights of the existing and proposed schemes. Simulation results verify the performance improvement as well as the theoretical analysis.
Enhanced launch-off-capture transition fault testing (2006)

A novel scan-based at-speed test is proposed in which a transition can be launched either from the scan path or the functional path. The technique improves the controllability of transition fault testing and it does not require the scan enable to change at-speed. The scan enable control information is encapsulated in the test data and transferred during the scan operation to generate the local scan enable signals during the launch and capture cycle. A new scan cell, referred to as local scan enable generator (LSEG), is inserted in the scan chains to generate the local scan enable signals. The proposed technique is robust, practice-oriented and suitable for designs targeted for very low cost ATEs.
Step coverage prediction in low-pressure chemical vapor deposition (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStep coverage prediction in low-pressure chemical vapor depositionGregory B. Raupp and T. S. CaleCite this: Chem. Mater. 1989, 1, 2, 207–214Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/cm00002a009https://doi.org/10.1021/cm00002a009research-articleACS PublicationsRequest reuse permissionsArticle Views660Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Family Processes in the Development of Anxiety Problems (2001)

Abstract The aim of this chapter is to review family processes with regardto development and maintenance of anxiety disorders in young people. It outlines the role of the family as a causal pathway to anxiety, family transmission, issues in directly measuring anxiety in children and families, and pre-anxious risk factors and family processes. It reviews empirical research findings in the area, along with studies on social learning and attachment processes in anxious children.
The role of poly(acrylic acid) in conventional glass polyalkenoate cements (2015)

Abstract Glass polyalkenoate cements (GPCs) have been used in dentistry for over 40 years. These novel bioactive materials are the result of a reaction between a finely ground glass (base) and a polymer (acid), usually poly(acrylic acid) (PAA), in the presence of water. This article reviews the types of PAA used as reagents (including how they vary by molar mass, molecular weight, concentration, polydispersity and content) and the way that they control the properties of the conventional GPCs (CGPCs) formulated from them. The article also considers the effect of PAA on the clinical performance of CGPCs, including biocompatibility, rheological and mechanical properties, adhesion, ion release, acid erosion and clinical durability. The review has critically evaluated the literature and clarified the role that the polyacid component of CGPCs plays in setting and maturation. This review will lead to an improved understanding of the chemistry and properties of the PAA phase which will lead to further innovation in the glass-based cements field.
Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity (1995)

Recent evidence suggests that the production of nitric oxide (NO) may have important roles in the regulation of osteoblast and osteoclast metabolism. The present study was performed to investigate the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) on the expression of inducible NO-synthase (iNOS) and to measure high-output production of NO by primary rat osteoblasts and osteoblastic cell lines ROS 17/2.8, MC3T3-E1 and MG-63. In addition, we have investigated if NO may mediate some of the effects of these cytokines on osteoblast metabolism. Northern blots and immunocytochemistry revealed time-dependent iNOS messenger RNA and protein expression in primary rat osteoblasts in response to cytokine treatment. Reverse transcription polymerase chain reaction amplified an 807-base pair (bp) product from ROS 17/2.8 cells, which had a size and restriction enzyme-cut pattern identical to that predicted for authentic rat iNOS. Nitrite accumulation in culture medium was induced by IFN-gamma in a time- and dose-dependent manner and inhibited by cotreatment with inhibitors of NOS activity and by dexamethasone. IL-1 beta, TNF-alpha, and bacterial lipopolysaccharide were found to have weak stimulatory effects on nitrite production on their own. However, IL-1 beta and TNF-alpha showed strong synergy with IFN-gamma, but, surprisingly, lipopolysaccharide was found to exert potent inhibitory effects on IFN-gamma-induced nitrite synthesis. Basal production of nitrite and induction of its synthesis was similarly observed with primary rat osteoblasts as well as ROS 17/2.8, MC3T3-E1, and MG-63 cell lines. Cytokine-induced NO production significantly reduced osteoblast activity, as was evidenced by inhibition of DNA synthesis, cell proliferation, alkaline phosphatase activity, and osteocalcin production. The results provide evidence for a basal expression of iNOS activity and show that the iNOS messenger RNA, protein, and enzyme activity are all induced by cytokines across the species. The data further suggest that osteoblast-derived NO may have an important role in mediation of localized bone destruction associated with inflammatory bone diseases such as rheumatoid arthritis.
Experimental Investigation of Automatic Signature Verification (1974)

This paper describes an approach to the problem of signature verificzation that treats the signature as a two-dimensional image and uses the Hadamard transform of that image as a means of data reduction and feature selection. This approach does not depend on the language or alphabet used and is general enough to have applications in such areas as cloud pattern surveys, aerial reconnaisance, and human-face recognition.
The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia (2012)

The polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by various stimuli such as cell swelling, low pH and high temperature. Therefore, TRPV4-mediated calcium entry may be involved in neuronal and glia pathophysiology associated with various disorders of the central nervous system, such as ischemia. The TRPV4 channel has been recently found in adult rat cortical and hippocampal astrocytes; however, its role in astrocyte pathophysiology is still not defined. In the present study, we examined the impact of cerebral hypoxia/ischemia (H/I) on the functional expression of astrocytic TRPV4 channels in the adult rat hippocampal CA1 region employing immunohistochemical analyses, the patch-clamp technique and microfluorimetric intracellular calcium imaging on astrocytes in slices as well as on those isolated from sham-operated or ischemic hippocampi. Hypoxia/ischemia was induced by a bilateral 15-minute occlusion of the common carotids combined with hypoxic conditions. Our immunohistochemical analyses revealed that 7 days after H/I, the expression of TRPV4 is markedly enhanced in hippocampal astrocytes of the CA1 region and that the increasing TRPV4 expression coincides with the development of astrogliosis. Additionally, adult hippocampal astrocytes in slices or cultured hippocampal astrocytes respond to the TRPV4 activator 4-alpha-phorbol-12,-13-didecanoate (4αPDD) by an increase in intracellular calcium and the activation of a cationic current, both of which are abolished by the removal of extracellular calcium or exposure to TRP antagonists, such as Ruthenium Red or RN1734. Following hypoxic/ischemic injury, the responses of astrocytes to 4αPDD are significantly augmented. Collectively, we show that TRPV4 channels are involved in ischemia-induced calcium entry in reactive astrocytes and thus, might participate in the pathogenic mechanisms of astroglial reactivity following ischemic insult.
ChemInform Abstract: Synthesis of 1‐(Phenylsulfonyl)indol‐3‐yl Trifluoromethanesulfonate. (1990)

Abstract Oxidation of 1‐phenylsulfonylindole (I) with magnesium monoperphthalate yields 1,2‐dihydro‐1‐(phenylsulfonyl)‐3H‐indol‐3‐one (II) which is converted into the 3‐indolyl trifluoromethanesulfonate (IV) by treatment with triflic anhydride (III).
Fast mapping of the <i>T</i><sub>2</sub> relaxation time of cerebral metabolites using proton echo‐planar spectroscopic imaging (PEPSI) (2007)

Metabolite T2 is necessary for accurate quantification of the absolute concentration of metabolites using long-echo-time (TE) acquisition schemes. However, lengthy data acquisition times pose a major challenge to mapping metabolite T2. In this study we used proton echo-planar spectroscopic imaging (PEPSI) at 3T to obtain fast T2 maps of three major cerebral metabolites: N-acetyl-aspartate (NAA), creatine (Cre), and choline (Cho). We showed that PEPSI spectra matched T2 values obtained using single-voxel spectroscopy (SVS). Data acquisition for 2D metabolite maps with a voxel volume of 0.95 ml (32 x 32 image matrix) can be completed in 25 min using five TEs and eight averages. A sufficient spectral signal-to-noise ratio (SNR) for T2 estimation was validated by high Pearson's correlation coefficients between logarithmic MR signals and TEs (R2 = 0.98, 0.97, and 0.95 for NAA, Cre, and Cho, respectively). In agreement with previous studies, we found that the T2 values of NAA, but not Cre and Cho, were significantly different between gray matter (GM) and white matter (WM; P < 0.001). The difference between the T2 estimates of the PEPSI and SVS scans was less than 9%. Consistent spatial distributions of T2 were found in six healthy subjects, and disagreement among subjects was less than 10%. In summary, the PEPSI technique is a robust method to obtain fast mapping of metabolite T2.
Solvent Extraction with Alkyl Amines (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent Extraction with Alkyl AminesC. F. Coleman, K. B. Brown, J. G. Moore, and D. J. CrouseCite this: Ind. Eng. Chem. 1958, 50, 12, 1756–1762Publication Date (Print):December 1, 1958Publication History Published online1 May 2002Published inissue 1 December 1958https://pubs.acs.org/doi/10.1021/ie50588a032https://doi.org/10.1021/ie50588a032research-articleACS PublicationsRequest reuse permissionsArticle Views1117Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
iBOM: A Platform for Intelligent Business Operation Management (2005)

As IT systems become more and more complex and as business operations become increasingly automated, there is a growing need from business managers to have better control on business operations and on how these are aligned with business goals. This paper describes iBOM, a platform for business operation management developed by HP that allows users to i) analyze operations from a business perspective and manage them based on business goals; ii) define business metrics, perform intelligent analysis on them to understand causes of undesired metric values, and predict future values; iii) optimize operations to improve business metrics. A key aspect is that all this functionality is readily available almost at the click of the mouse. The description of the work proceeds from some specific requirements to the solution developed to address them. We also show that the platform is indeed general, as demonstrated by subsequent deployment domains other than finance.
Complement Receptor Type 1 Gene Regulation: Retinoic Acid and Cytosine Arabinoside Increase CR1 Expression (1999)

Complement receptor type 1 (CR1) is expressed principally on erythrocytes, monocytes, neutrophils and B cells, where it acts as a negative regulator of the complement cascade and as a clearance mechanism for immune complexes. As CR1 expression occurs in a number of lineages, its regulation may parallel other steps in haematopoiesis. Several leucocyte-cell lines (including K-562, THP-1, U-937 and HL-60) and B-cell lines, as well as peripheral blood cells (PBCs), were tested for the ability of various compounds to up-regulate their CR1 expression. While most of the compounds tested had minimal effects on CR1 message level, retinoic acid induced increases in mRNA levels in nearly all cell lines studied. Furthermore, in K-562 cells, the cytosine analogue Ara-C, an inducer of erythroid differentiation, caused the highest increases in CR1 mRNA levels as compared to untreated cells. Ara-C also induced significant increases in CR1 message in PBCs. These data suggest that induction of specific CR1 expression could be an integral part of blood cell differentiation and that the identified cell induction systems may be useful as models to study the regulation of CR1 gene expression.
Steroidal Cyclic Ketals. XI.<sup>1</sup> The Conversion of 11-epi-Hydrocortisone into Hydrocortisone (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal Cyclic Ketals. XI.1 The Conversion of 11-epi-Hydrocortisone into HydrocortisoneWilliam S. Allen, Seymour Bernstein, and Ruddy LittellCite this: J. Am. Chem. Soc. 1954, 76, 23, 6116–6119Publication Date (Print):December 1, 1954Publication History Published online1 May 2002Published inissue 1 December 1954https://pubs.acs.org/doi/10.1021/ja01652a075https://doi.org/10.1021/ja01652a075research-articleACS PublicationsRequest reuse permissionsArticle Views337Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Use of Perfluorodecalin as a Reaction Medium for the Preparation of Anhydrous Metal Bromides (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTUse of Perfluorodecalin as a Reaction Medium for the Preparation of Anhydrous Metal BromidesThomas G. Hibbert, Dennis G. Tuck, and Kenneth WadeView Author Information Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, U.K.Cite this: Inorg. Chem. 1997, 36, 4, 746Publication Date (Web):February 12, 1997Publication History Received11 September 1996Published online12 February 1997Published inissue 12 February 1997https://pubs.acs.org/doi/10.1021/ic9611148https://doi.org/10.1021/ic9611148brief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views180Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Bromine,Elements,Metals,Solvents Get e-Alerts
Secure governance in enterprise architecture &#x2014; Access control perspective (2013)

Enterprise Architecture (EA) models have proven to be very useful for the management and governance of enterprises. Such EA models are used for analysis and steering purposes, thereby leading to a competitive advantage for the enterprise. However, the management of EA model evolution from an initial (As-is) to an a posterior (To-be) state is a challenging task for EA modelers, due to the huge number and the complex dependencies amongst models. In this paper, we tackle the challenge of a controlled evolution of EA models which seeks to give more control to EA modelers over what the impact of EA evolution means in terms of properties (e.g. security) of the EA. We propose a core knowledge model for representing EA evolution which supports the EA modeler in deciding about the (To-be) model compliance. Our model is based on the three notions of change operation, artifact-to-artifact dependency, and reactive event-condition-action (ECA) rules. We instantiate our approach for the case where security properties must be maintained through EA evolution.