gebhart/patrepeval huggingface dataset:
Temperature-induced structural static responses of a long-span steel box girder suspension bridge (2020)

Temperature is a significant load on bridges, particularly for long-span steel box girder bridges. This study investigates the temperature-induced static responses of a long-span suspension bridge under real service environmental conditions using numerical simulations and field measurements. Detailed 2D finite element (FE) models of a typical section for the box girder, main cable, hanger, tower column, and crossbeam are constructed. The thermal boundary conditions are determined strictly according to the surrounding environments of a typical sunny day and applied to the FE models. A transient heat-transfer analysis is performed and the time-dependent temperature and its distribution on the bridge are obtained. In addition, a fine, 3D FE model of the bridge is developed for a structural analysis. The calculated temperatures are applied to the 3D model and the temperature-induced structural responses are simulated. The simulated temperatures and the associated static responses have good agreement with the measured counterparts and support the numerical simulation method. The main cable and bridge deck make the greatest contributions to the temperature effects on the suspension bridge. The static responses of bridge caused by the design vehicle load are also calculated. The daily variation of the temperature-induced static responses is comparable with, even higher than, that of the design vehicle load.
Toward a Total Synthesis of Peloruside A:  Enantioselective Preparation of the C8−C19 Region (2003)

An efficient synthetic sequence toward the C8-C19 region of peloruside A has been developed. The route is highlighted by a selective electrophilic cyclization reaction, a single-step epoxide ring-opening/methylation sequence, and a stereoselective Mukaiyama aldol reaction. [reaction: see text]
Tunable quasi-phase matching using <i>dynamic</i> ferroelectric domain gratings induced by photorefractive space-charge fields (1994)

We demonstrate a method of dynamic, tunable quasi-phase matched second-harmonic generation using optically induced polarization gratings with periods equal to twice the coherence length. These gratings increase the peak second-harmonic conversion efficiency by a factor of 17 above a poled strontium barium niobate crystal, to 0.01% for fundamental beam intensities of 0.8 MW cm−2. We generate quasi-phase matching spectral response peaks as narrow as 0.175 nm and tailor the response by writing an ensemble of gratings in the same volume, each of which enhances the second-harmonic generation at a predetermined wavelength.
Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans‐sialidase (2000)

Infective forms of Trypanosoma cruzi, the parasite that causes Chagas' disease, express on their surface an enzyme denominated trans-sialidase (TS). The present study was designed to evaluate the naturally acquired immune responses to a bacterial recombinant protein representing the catalytic domain of TS in chronically infected chagasic individuals. The cellular immune response was measured by in-vitro T-cell proliferation and by interferon (INF)-gamma, interleukin (IL)-4 and IL-10 production in response to a whole-parasite homogenate and the recombinant protein. The peripheral blood mononuclear cells of 78.6% of 28 chagasic patients responded to the recombinant protein as estimated by T-cell proliferation. With respect to cytokine production, 88% of the cells of the chagasic individuals produced IFN-gamma on stimulation with the recombinant protein. In contrast, IL-4 or IL-10 were minimally produced in response to TS. The cellular immune response was specific because most healthy individuals never exposed to T. cruzi failed to react with this recombinant protein. The plasma of 71.4% or 100% of chagasic patients had IgG antibodies as determined by ELISA or by the presence of TS inhibitory antibodies, respectively. We conclude that the catalytic domain of TS is recognized by IFN-gamma producing type 1 cells and antibodies in a large proportion of patients infected with T. cruzi.
Radiation Damage to Histone H2A by the Primary Aqueous Radicals (1987)

Histone H2A has been examined for radiation-induced changes in structure and in amino acid composition. The effects of the individual radical intermediates--the hydroxyl radical, solvated electron, and superoxide radical--have been determined by irradiating in dilute aqueous solution under controlled environmental conditions. Amino acid analysis of irradiated histone H2A shows a selective attack on a few residues; only the aromatic residues, phenylalanine and tyrosine, and the heterocyclic residue, histidine, are significantly decreased. A significant increase in aspartic acid is also observed. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis shows that the hydroxyl radical is the effective radical for promoting changes in protein structure.
Erratum: Optical Polarization Modulation and Gain Anisotropy in an Electrically Injected Spin Laser [Phys. Rev. Lett.<b>102</b>, 093904 (2009)] (2009)

Received 12 March 2009DOI:https://doi.org/10.1103/PhysRevLett.102.129901©2009 American Physical Society
Halogen-Bond-Promoted Photoactivation of Perfluoroalkyl Iodides: A Photochemical Protocol for Perfluoroalkylation Reactions (2017)

A new protocol for photochemical perfluoroalkylation reactions using perfluoroalkyl iodide, amine additive, and THF solvent is reported. This protocol does not require a photoredox catalyst and proceeds at ambient temperature with irradiation from a compact fluorescent lamp, low-intensity UV lamp, or sunlight. This protocol can be applied to the synthesis of perfluoroalkyl-substituted phenanthridines as well as effect the iodo-perfluoroalkylation of alkenes/alkynes and the C-H perfluoroalkylation of electron-rich arenes and heteroarenes. This C-H perfluoroalkylation reaction offers a unique method for site-selective labeling of oligopeptides at the tryptophan residue.
Designing a Power-Aware Replication Strategy for Storage Clusters (2013)

The exponential data growth is presenting challenges to traditional storage systems. Component-based cluster storage systems, due to their high scalability, are becoming the architecture of next generation storage systems. Cluster storage systems often use data replication to ensure high availability, fault tolerance, and load balance. However, this kind of data replication not only consumes a large amount of storage resources, but also generates more energy consumption. This paper presents a power-aware data replication strategy by leveraging data access behavior. This strategy uses 80/20 rule (80% of the data accesses often go to 20% of the storage space) to replicate only a small amount of frequently accessed data. Furthermore, the storage nodes are divided into a hot node set and a cold node set. Hot nodes, which store a small amount of hot data copies, are always in an active state to guarantee the QoS of the system. The cold nodes which store a large number of infrequently accessed cold data, are placed in a low power state, thus reducing the energy consumption of the cluster storage system. The experimental results show that the proposed strategy can effectively reduce the resource and energy consumption of the system, while ensuring the system performance.
Characterization of Metal Binding Peptides from Cadmium Resistant Plant Cells (1987)

The majority of the cellular cadmium (less than 80%) in cadmium resistant Datura innoxia cells is bound to a small, metal induced peptide which is not metallothionein. This peptide consists of glutamate, cysteine and glycine in a ratio between 2:2:1 and 3:3:1 and has an apparent molecular weight of 776, under denaturing conditions. It is heat stable and complexes with cadmium to produce multimeric forms which are separable by gel filtration. Chemical analyses suggest that some amino acids are not joined by classical peptide linkages. This indicates that the synthesis of the peptide may not be directed by mRNA and that induction of its synthesis may not involve increased transcription from a putative gene corresponding directly to this peptide. A smaller proportion (greater than 15%) of the cellular cadmium is bound to a larger compound which is also heat stable and binds copper more readily than cadmium in vivo. This larger compound has an amino acid composition similar, in some respects, to metallothioneins.
Cutting-tool reliability assessment in variable machining conditions (1996)

It is a common industrial practice to use the same cutting tool for different operations and on different part types to minimize cutting-tool change-overs and the number of cutting-tools required, and to increase part-routing flexibility. This paper derives a recursive formula to calculate the cutting-tool reliability in variable conditions if the failure-time distribution of the cutting-tool can be represented by the accelerated failure time model (AFTM). The formulae for the cutting-tool reliability when the processing time for each operation is random are also derived. The unknown parameters in the reliability function can be estimated from cutting-tool life-data obtained under either fixed conditions or variable conditions by using the method of maximum likelihood. Two examples based on real cutting-tool life-data demonstrate the computational results.
2,3–Dihydroxybenzoic Acid Decarboxylase from <i>Aspergillus niger</i> (1995)

2,3-Dihydroxybenzoic acid decarboxylase, the last enzyme in the fungal metabolism of indole to catechol, catalyzes the non-oxidative decarboxylation of 2,3-dihydroxybenzoic acid to catechol. Unlike most other decarboxylases, this enzyme does not require a cofactor, underlining the importance of active-site residues in the reaction mechanism. Earlier studies from this laboratory [Kamath, A. V., Appaji Rao, N. & Vaidyanathan, C. S. (1989) Biochem. Biophys. Res. Commun. 165, 20-26], have shown that the sulfhydryl agent N-ethylmaleimide (MalNEt) inactivated the enzyme by modifying a single class of cysteine residues and that this inactivation was prevented in the presence of salicylate, a substrate analogue. In the present study, this essential cysteine residue has been identified by specific labelling with [14C]-MalNEt using the differential labelling technique. The stoichiometry of incorporation of [14C]MalNEt was approximately one/subunit of the homotetrameric protein. The peptide bearing this reactive cysteine residue was isolated by tryptic digestion of the differentially labelled enzyme and subsequent reverse-phase chromatography of the peptide mixture. The sequence of the major radioactive peptide that was identified to be the active-site peptide, was LLGLAETCK. A search for sequences similar to this active-site peptide indicated that this sequence was probably unique to the decarboxylase under study. A partial primary structure map constructed from the sequences of peptides derived from enzymic cleavage of the protein using endoproteinase Glu-C and trypsin did not share any significant sequence similarity with sequences reported in the database, again suggesting the uniqueness of the enzyme. This is the first report on the active-site peptide and the partial primary structure of a non-oxidative decarboxylase catalyzing the removal of a carboxyl group from an aromatic nucleus.
Fluorocarbanion chemistry. A versatile synthesis of functionalized fluoro ketones (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorocarbanion chemistry. A versatile synthesis of functionalized fluoro ketonesCarl G. Krespan and Bruce E. SmartCite this: J. Org. Chem. 1986, 51, 3, 320–326Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/jo00353a009https://doi.org/10.1021/jo00353a009research-articleACS PublicationsRequest reuse permissionsArticle Views723Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient data dissemination and aggregation in large wireless sensor networks (2005)

In this paper, we investigate an energy-efficient data dissemination scheme that prolongs the lifetime of battery-powered sensors by reducing the amount of communication required. In order to save energy and bandwidth, the proposed scheme constructs and maintains only one grid structure per data type, and sources of same data type share the grid structure to disseminate sensing data. Another novel idea in the proposed scheme is to use a hash function in order to retrieves the position of the nearest grid point. By using a hashing function, a sink can substitute expensive local query flooding with unicasting. Our simulation results show that the proposed scheme consumes much less energy than previously known schemes by sharing grid structures and eliminating local flooding.
Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein (2019)

Heat shock proteins play roles in assisting other proteins to fold correctly and in preventing the aggregation and accumulation of proteins in misfolded conformations. However, the process of aging significantly degrades this ability to maintain protein homeostasis. Consequently, proteins with incorrect conformations are prone to aggregate and accumulate in cells, and this aberrant aggregation of misfolded proteins may trigger various neurodegenerative diseases, such as Parkinson's disease. Here, we investigated the possibilities of suppressing α-synuclein aggregation by using a mutant form of human chaperonin Hsp60, and a derivative of the isolated apical domain of Hsp60 (Hsp60 AD(Cys)). In vitro measurements were used to detect the effects of chaperonin on amyloid fibril formation, and interactions between Hsp60 proteins and α-synuclein were probed by quartz crystal microbalance analysis. The ability of Hsp60 AD(Cys) to suppress α-synuclein intracellular aggregation and cytotoxicity was also demonstrated. We show that Hsp60 mutant and Hsp60 AD(Cys) both effectively suppress α-synuclein amyloid fibril formation, and also demonstrate for the first time the ability of Hsp60 AD(Cys) to function as a mini-chaperone inside cells. These results highlight the possibility of using Hsp60 AD as a method of prevention and treatment of neurodegenerative diseases.
Triterpene Acids in Callus Tissues from<i>Mentha arvensis</i>var.<i>piperascens</i>Mal (1980)

Journal Article Triterpene Acids in Callus Tissues from Mentha arvensis var. piperascens Mal Get access Den’ei Karasawa, Den’ei Karasawa Department of Agricultural Chemistry, Faculty of Agriculture, Shinshu University, Ina, Nagano 396, Japan Search for other works by this author on: Oxford Academic Google Scholar Sumio Shimizu Sumio Shimizu Department of Agricultural Chemistry, Faculty of Agriculture, Shinshu University, Ina, Nagano 396, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 44, Issue 5, 1 May 1980, Pages 1203–1205, https://doi.org/10.1080/00021369.1980.10864105 Published: 01 May 1980 Article history Received: 07 January 1980 Published: 01 May 1980
Unstimulated Human CD4 Lymphocytes Express a Cytoplasmic Immature Form of the Common Cytokine Receptor γ-Chain (2001)

As a component of various cytokine receptors, common cytokine receptor gamma-chain (gamma(c)) is essential in the development of the immune system and plays an important role in different stages of inflammatory and immune responses. Here we establish that resting CD4 T cells and the Jurkat CD4 T cell line do not express the mature form of gamma(c) (64 kDa) recognized by mAb Tugh4. However, these cells constitutively transcribe the corresponding gamma(c) gene. This apparent paradox was solved by the demonstration that polyclonal anti-gamma(c) Abs detected endoglycosidase-H-sensitive immature forms of gamma(c) (54-58 kDa) expressed by quiescent CD4 T lymphocytes and Jurkat cells. Immature gamma(c) is characterized as an intracellular component localized in the endoplasmic reticulum. Pulse-chase analysis shows that the immature gamma(c) is rapidly degraded after synthesis. After activation of CD4 T lymphocytes, and as seen in the CD4 T cell line Kit 225, the endoglycosidase-H-resistant mature form of gamma(c) is detectable at the cell surface and in the endosomal compartment. For the first time, our results demonstrate that a cytokine receptor chain may be constitutively produced as an immature form. Furthermore, this supports the notion that expression of the functional form of gamma(c) may require intracellular interactions with lineage- or subset-specific molecular partners.
5-Nitro-2-furyl-substituted 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles, and 1,3,5-Triazines<sup>1</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT5-Nitro-2-furyl-substituted 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles, and 1,3,5-Triazines1WILLIAM R. SHERMANCite this: J. Org. Chem. 1961, 26, 1, 88–95Publication Date (Print):January 1, 1961Publication History Published online1 May 2002Published inissue 1 January 1961https://pubs.acs.org/doi/10.1021/jo01060a021https://doi.org/10.1021/jo01060a021research-articleACS PublicationsRequest reuse permissionsArticle Views388Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measurement of Interfacial Energy at Solid Polymer Surfaces (1996)

Interfacial energy plays the role of a multiplicative prefactor to rate-dependent rheological phenomena in practical measurements of adhesion energy. Interfacial energy can also be correlated, in ways yet to be fully understood, with measurements of coefficient of friction between solid surfaces. In this note, some points are made about the utility of the JKR methods of contact mechanics for the accurate determination of interfacial energies. Issues that arise are: the adaptability of the methods to various types and states of polymeric materials; rearrangement of surfaces during interfacial contact and; viscoelasticity of materials and its influence on JKR interfacial energy measurement.
Concurrent Sulforaphane and Eugenol Induces Differential Effects on Human Cervical Cancer Cells (2011)

This study clearly indicates that 2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention.
Simultaneous imaging of several focal planes in fluorescence microscopy for the study of cellular dynamics in 3D (2006)

Fluorescence microscopy of live cells is an important tool to investigate cellular tracking pathways. The existing microscope design is very well suited to image fast moving vesicles, tubules and organelles in one focal plane. More problematic is the imaging of cellular components that move between different focal planes. This is due to the fact that tracking of such cellular components requires that the focal plane of the microscope be changed. This has to be done with a focusing device, which is relatively slow. More importantly, only one focal plane can be imaged at a time. Therefore, while the cell is imaged at one focal plane, important events could be missed at other focal planes. To overcome these shortcomings, we present a modification of the classical microscope design with which two or more focal planes can be imaged simultaneously. In this design, the emission light collected by a single stationary objective lens is split into multiple channels. Light in each channel is focused on a CCD camera by a tube lens. By ensuring that the camera position with respect to the tube lens focal plane position is not the same in any two channels, distinct planes within the specimen can be simultaneously imaged. Here we discuss the implementation of a configuration with which four focal planes can be imaged simultaneously.
Low-cost dual-frequency microwave antenna (1977)

Antenna is circularly-polarized microwave device with high-band frequency and low-band frequency elements. Relatively low impedance of low-band frequency element can be matched to desired impedance by adding etched matching network.
The microarchitecture of a low power register file (2003)

The access time, energy and area of the register file are often critical to overall performance in wide-issue microprocessors, because these terms grow superlinearly with the number of read and write ports that are required to support wide-issue. This paper presents two techniques to reduce the number of ports of a register file intended for a wide-issue microprocessor without hardly any impact on IPC. Our results show that it is possible to replace a register file with 16 read and 8 write ports, intended for an eight-issue processor, with a register file with just 8 read and 8 write ports so that the impact on IPC is a few percent. This is accomplished with the addition of several small auxiliary memory structures -- a write-back queue and a operand prefetch buffer. We examine several configurations employing these structures separately and in combination. In the case of just the delayed write-back queue, we show an energy per access savings of about 40% and an area savings of 40%. This incurs a performance loss of just 4%. The area savings in turn has the potential for further savings by shortening global interconnect in the layout. We also show that the performance loss can be almost eliminated if both techniques are used in combination, although some area and power savings is lost.