gebhart/patrepeval huggingface dataset:
Application of porous teflon tubing method to automatic fed‐batch culture of microorganisms. I. Mass transfer through porous teflon tubing (1981)

Abstract For the purpose of a rational design for an automatic feedback control system incorporating a porous Teflon tubing sensor in semibatch culture, steady‐state mass‐transfer characteristics of tubing sensors have been investigated theoretically and experimentally, and also dynamic responses have been studied experimentally. A distributed mathematical model for steady‐state diffusion has been solved numerically and its solution has been shown as useful for the sensor design. The overall mass‐transfer resistance of radial diffusion has been shown to be the sum of external liquid‐film mass‐transfer resistance and membrane diffusion resistance. The steady‐state experiments using ethanol dissolved in water revealed that its transfer into the tubing was controlled by the molecular diffusion within the tubing‐wall membrane. Oxygen transfer from external water into the tubing was shown experimentally to be controlled by the liquid‐film resistance outside the tubing. In general, the radial mass transfer of a substance having a small Henry's constant is controlled by the liquid‐film resistance. The response of the tubing sensor‐detector‐recorder system for the stepwise addition of ethanol into the external water could not be represented by a simple combined system of the first‐order delay with lag time. The responses depend on the characteristics of the tubing as well as flow rate of the carrier gas, etc., but they were quite excellent in all cases (e.g., 90% in 20 s).
A Guide to FASTGEN Target Geometric Modeling (1993)

Vulnerability analysis programs, such as COVART, require target description data of sufficient detail and completeness to represent the physical and geometric detail of a target model from any attack aspect. The FASTGEN 3 computer model is used to generate the target description by developing a listing of the physical dimensions of target components, component location, and air spaces encountered along parallel shotlines passing through the target from a specified attack direction. A prerequisite to the execution of FASTGEN is the development of a geometric description of a target whose exterior and interior components surfaces are described using triangles, spheres, cones, cylinders, and rods. The objective of this manual is to provide a guide to experienced and inexperienced model developers to assist them in developing geometric models using the CONVERT computer code to generate target description data in the FASTGEN format. Specific model preparation procedures, recommended procedures, frequently encountered pitfalls and proven shortcut model preparation procedures are discussed. Emphasis is placed on the use of CONVERT constructs in model development. Vulnerability, Target recognition, Geometric target description, Geometric modeling.
Age and gender classification from speech using decision level fusion and ensemble based techniques (2010)

In this contribution to INTERSPEECH 2010 Paralinguistic Challenge we explore the capabilities of decision level fusion and ensemble based techniques for classification tasks on the provided AGENDER corpus.Ensemble members are generated by providing multiple feature sets generated by feature selection, and novel fusion methods (developed in order to give special support to under-represented classes) are applied for decision making.Results are compared to standard classification approaches and possible benefits are discussed.
A New Approach to Client Onboarding Using Self-Sovereign Identity and Distributed Ledger (2018)

Existing client onboarding and Know Your Customer (KYC) processes are typically slow, expensive and often accomplished in-person. Moreover, the current identity management models in practice deprive users from having complete control over their digital identity data. Users' identity attributes are stored on multiple centralized repositories, which often follow inadequate security policies. In this paper, we take advantage of Hyperledger Indy, a public and permissioned distributed ledger technology (DLT), to develop a digital onboarding framework based on the Self-Sovereign Identity (SSI) principles. With this framework we take a step towards tackling a number of weaknesses in current KYC processes and identity management models, while addressing the requirements associated with SSI, Privacy by Design and European Union's General Data Protection Regulation (GDPR).
Hindered amines. Novel synthesis of 1,3,3,5,5-pentasubstitued 2-piperazinones (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHindered amines. Novel synthesis of 1,3,3,5,5-pentasubstitued 2-piperazinonesJohn T. LaiCite this: J. Org. Chem. 1980, 45, 4, 754–755Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://doi.org/10.1021/jo01292a054RIGHTS & PERMISSIONSArticle Views422Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (283 KB) Get e-Alerts Get e-Alerts
Retinoic acid inhibits the expression of cytidine deaminase linked to the differentiation of the human leukemic cell line HL-60. (1991)

The activity of cytidine deaminase markedly increases during the differentiation of HL-60 cells induced by dimethylsulfoxide or 1,25-dihydroxy vitamin D3, but does not increase when the inducer is retinoic acid. Here it is demonstrated that retinoic acid inhibits the increase in cytidine deaminase activity elicited by the other two inducers. This inhibitory effect of retinoic acid (i) was not the result of a direct action on the enzymatic activity; (ii) was correlated with the differentiating effect of retinoic acid, as indicated by the similar time-course and dose-dependence of both effects, and by additional studies with various retinoids and with an HL-60 variant resistant to retinoic acid-induced differentiation; (iii) required the continued presence of the drug for more than 24 h, and could not be reversed after 48 h; (iv) was manifest, after a lag-time of 24 h, at whatever time retinoic acid was added during the 5 days of treatment of the cells with the differentiation inducers; and (v) was prevented by the addition of the protein synthesis inhibitor cycloheximide. These data indicate that retinoic acid negatively regulates the expression of cytidine deaminase in HL-60 cells, and suggest that this effect is mediated by a protein, the synthesis of which should be controlled by the nuclear receptor of retinoic acid.
The preparation of nerve growth factors from snake venom (1968)

Research Article| June 01 1968 The preparation of nerve growth factors from snake venom B E Banks; B E Banks 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar D V Banthorpe; D V Banthorpe 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar A R Berry; A R Berry 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar H S Davies; H S Davies 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar S Doonan; S Doonan 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar D M Lamont; D M Lamont 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar R Shipolini; R Shipolini 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar C A Vernon C A Vernon 1Departments of Chemistry and Physiology, University College London, Gower Street, London, W.C. 1 Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1968) 108 (1): 157–158. https://doi.org/10.1042/bj1080157 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation B E Banks, D V Banthorpe, A R Berry, H S Davies, S Doonan, D M Lamont, R Shipolini, C A Vernon; The preparation of nerve growth factors from snake venom. Biochem J 1 June 1968; 108 (1): 157–158. doi: https://doi.org/10.1042/bj1080157 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1968 The Biochemical Society1968 Article PDF first page preview Close Modal You do not currently have access to this content.
Should second eye cataract surgery be rationed? (1995)

To conserve limited resources, healthcare purchasers are questioning whether they should ration second eye cataract surgery after successful unilateral extraction. The effect this would have on overall cataract workload is unknown. The clinical indications for performing second eye cataract extraction were recorded from the medical notes of a random group of patients undergoing second eye surgery over a 1 year period. Twenty-six per cent of all cataract operations were on second eyes and, of these, 21.5% of operations were on patients with coexistent ocular pathology, requiring clear optical media for disease monitoring, and 18.4% were on patients who had failed to achieve a satisfactory result after unilateral cataract surgery (visual acuity 6/18 or worse). Another 43.6% had severe binocular visual disability due to their remaining cataract. Only 4.4% of all cataract operations performed during the study period were on second eyes of patients with no other ocular pathology who had had successful unilateral surgery and had only mild symptoms from their remaining cataract (visual acuity 6/12 or better in second eye). Therefore, the overall savings made by rationing second eye cataract surgery to those patients who have only mild visual disability would be slight. If the proportion of cataract operations performed as daycases under local anaesthetic were increased, sufficient resources would be released to enable all patients to achieve maximum binocular visual rehabilitation.
A compressive sensing framework for seismic source parameter estimation (2012)

Simultaneous estimation of origin time, location and moment tensor of seismic events is critical for automatic, continuous, real-time monitoring systems. Recent studies have shown that such systems can be implemented via waveform fitting methods based on pre-computed catalogues of Green's functions. However, limitations exist in the number and length of the recorded traces, and the size of the monitored volume that these methods can handle without compromising real-time response. This study presents numerical tests using a novel waveform fitting method based on compressive sensing, a field of applied mathematics that provides conditions for sampling and recovery of signals that admit a sparse representation under a known base or dictionary. Compressive sensing techniques enable us to determine source parameters in a compressed space, where the dimensions of the variables involved in the inversion are significantly reduced. Results using a hypothetical monitoring network with a dense number of recording stations show that a compressed catalogue of Green's functions with 0.004 per cent of its original size recovers the exact source parameters in more than 50 per cent of the tests. The gains in processing time in this case drop from an estimated 90 days to browse a solution in the uncompressed catalogue to 41.57 s to obtain an estimation using the compressed catalogue. For simultaneous events, the compressive sensing approach does not appear to influence the estimation results beyond the limitations presented by the uncompressed case. The main concern in the use of compressive sensing is detectability issues observed when the amount of compression is beyond a minimum value that is identifiable through numerical experiments. Tests using real data from the 2002 June 18 Caborn Indiana earthquake show that the presence of noise and inaccurate Green's functions require a smaller amount of compression to reproduce the solution obtained with the uncompressed catalogue. In this case, numerical simulation enables the assessment of the amount of compression that provides a reasonable rate of detectability. Overall, the numerical experiments demonstrate the effectiveness of our compressed domain inversion method in the real-time monitoring of seismic sources with dense networks of receivers. As an added benefit of the compression process, the size of the monitored volume can also be increased under specific restrictions while maintaining the real-time response.
Multivariate Images, Hyperspectral Imaging: Background and Equipment (2007)

This chapter contains sections titled: Introduction Digital Images, Multivariate Images and Hyperspectral Images Hyperspectral Image Generation Essentials of Image Analysis Connecting Scene and Variable Spaces References
Composite Zeolite-Based Catalysts and Sorbents (1999)

Click to increase image sizeClick to decrease image size ACKNOWLEDGMENT The first author wishes to thank Dr. George Yaluris of W. R. Grace for useful discussions during the preparation of this article.
A vast collection of microbial genes that are toxic to bacteria (2012)

In the process of clone-based genome sequencing, initial assemblies frequently contain cloning gaps that can be resolved using cloning-independent methods, but the reason for their occurrence is largely unknown. By analyzing 9,328,693 sequencing clones from 393 microbial genomes, we systematically mapped more than 15,000 genes residing in cloning gaps and experimentally showed that their expression products are toxic to the Escherichia coli host. A subset of these toxic sequences was further evaluated through a series of functional assays exploring the mechanisms of their toxicity. Among these genes, our assays revealed novel toxins and restriction enzymes, and new classes of small, non-coding toxic RNAs that reproducibly inhibit E. coli growth. Further analyses also revealed abundant, short, toxic DNA fragments that were predicted to suppress E. coli growth by interacting with the replication initiator DnaA. Our results show that cloning gaps, once considered the result of technical problems, actually serve as a rich source for the discovery of biotechnologically valuable functions, and suggest new modes of antimicrobial interventions.
The Suppressive Effects of Calcium Compounds against Botrytis cinerea in Paprika (2010)

Plant diseases including gray mold caused by Botrytis cinerea are often reduced when calcium compounds are used as alternative materials in paprika. However, much less information is available about the effects of calcium compounds on controlling of B. cinerea. Seven calcium compounds such as calcium sulfate dihydrate, calcium chloride, calcium nitrate, calcium oxide, calcium hydroxide, calcium carbonate, and calcium hydride were evaluated for their effectiveness against B. cinerea on potato dextrose agar medium. The pH of selected calcium compounds was higher (pH 8.2-10) than that of the control (pH 6.6). Calcium carbonate, calcium oxide, calcium hydride, and calcium hydroxide among seven calcium compounds were more effectively inhibited the growth of B. cinerea than other calcium compounds. In the case of spraying the spore suspension on paprika applied with the selected four calcium compounds and supplied with the selected calcium supplements in a hydroponic culture system, the paprika treated with calcium compounds showed less severity of disease than those untreated plants. On the basis of our results, we propose that the suppressive effects of calcium compounds on B. cinerea in paprika resulted from the supply of calcium and a certain degree of salt stress.
Effect of hemolysis on oxygen and hematocrit measurements by near infrared reflectance spectroscopy (2002)

A short review of the principles of near infrared reflectance spectroscopy (NIRS) in whole blood is followed by a discussion on the influence of hemolysis. The increase of free plasmahemoglobin (PHb) has a strong influence on the continuous measurement of hematocrit and oxygen saturation (O(2)S) by NIRS. In view of the relative stability of hematocrit values in vivo this effect may be used to detect a change of the hemolysis rate induced by blood pumps in case of malfunction. The aim of this study is, therefore, the assessment of the hemolysis rate within an in vitro mock loop comprising a rotary blood pump by means of NIRS at constant hematocrit levels compared to the photometric reference method. Reflected light is measured by an integrated optical sensor working at three wavelengths (660 nm, 730 nm, and 830 nm). The experimental results demonstrate that the increase of free hemoglobin in plasma due to mechanical pumping leads to a decrease of detected reflected light at all three wavelengths. Influencing parameters such as adhering proteins on the sensor surface and the blood flow rate are briefly discussed. Finally, the possibility of using NIRS sensors for detecting malfunctions of blood pumps in vitro and in vivo is discussed, together with the option of using these sensors for supervision of long-term implantable pumps.
Guinea pig abscess/hypersensitivity model for study of adverse vaccination reactions induced by use of Q fever vaccines. (2000)

The CMR vaccine may prove a safe alternative to WCI vaccines for use in individuals unscreened for prior immunity to C. burnetii.
Single Reverse Blocking Switch Type Pulse Density Modulation Controlled ZVS Inverter with Boost Transformer for Dielectric Barrier Discharge Lamp Dimmer (2006)

This paper presents soft switching zero voltage switching high frequency inverter with reverse blocking single switch for dielectric barrier discharge lamp. The simple high-frequency inverter can completely achieve stable zero voltage soft switching (ZVS) commutation for wide its output power regulation ranges and load variations under its constant high frequency pulse density modulation (PDM) scheme. Its transient and steady state operating principle is originally described and discussed for a constant high-frequency PDM control strategy under a stable ZVS operation commutation, together with its output effective power regulation characteristics based on the high frequency PDM strategy. Its light dimming characteristics due to power regulation scheme are evaluated and discussed on the basis of simulation and experimental results. The feasible effectiveness of this high frequency inverter appliance implemented here is proven from the practical point of view
A Study of Employability between Higher Technical and Vocational Education and Employer in Tourism and Hospitality: A Stakeholder perspective (2013)

The purpose of this study is to analyze the relationship between tourism and hospitality education and work in terms of employability development as well as to discuss how higher education can contribute to such a development. To begin with, as a background, the relation between higher education and work has been described based on the already mentioned discrepancy discussion. Later, the concept of employability will be explored and discussed in general terms as well as regarding the tourism and hospitality. Finally, different ways of integrating employability in higher education curricula are discussed. Based on this discussion, we have some suggestions regarding the employability development within the tourism and hospitality industry.
[Arsenic trioxide in the treatment of advanced primary liver and gallbladder cancer]. (2001)

As2O3 injection is effective in treating primary liver and gallbladder cancer with mild side reactions. It is worth studying in the future.
Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis (2001)

We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1 phosphorylation are correlated with S-phase checkpoint proficiency, whereas neither is sufficient individually for checkpoint activation. The Nbs1 E2F interaction occurred near the Epstein-Barr virus origin of replication as well as near a chromosomal replication origin in the c-myc promoter region and was restricted to S-phase cells. The Mre11 complex colocalized with PCNA at replication forks throughout S phase, both prior to and coincident with the appearance of nascent DNA. These data suggest that the Mre11 complex suppresses genomic instability through its influence on both the regulation and progression of DNA replication.
Amphiphilic association of ibuprofen and two nonionic cellulose derivatives in aqueous solution (1999)

The aqueous interaction of the sodium salt of ibuprofen with the cellulose ethers ethyl hydroxyethyl cellulose, EHEC, and hydroxypropyl methyl cellulose, HPMC, has been investigated in the concentration range 0-500 mM ibuprofen and 0.1-1% (w/w) polymer, by cloud point, capillary viscometry, equilibrium dialysis, and fluorescence probe techniques. Ibuprofen forms micelles in pure water, with the critical micelle concentration, cmc, at 180 mM. A combination of time-resolved and static fluorescence quenching shows that micelle-like ibuprofen aggregates are formed in the solution. The average aggregation number of pure ibuprofen micelles in water is about 40. In the presence of EHEC or HPMC the aggregation numbers decrease. The interaction of ibuprofen with cellulose ethers is similar to the normally accepted model for polymer-surfactant interaction, although more complex. Ibuprofen adsorbs to the polymer in the form of mixed polymer-drug micelles, noncooperatively up to cmc and cooperatively when cmc is passed. The interaction starts below 50 mM ibuprofen as monitored by the fluorescent probes pyrene and 1,3-di(1-pyrenyl)propane, P3P, with a maximum in microviscosity below cmc, corresponding to polymer-dense mixed micelles. The study illustrates the importance of a precise apprehension of the aggregation behavior as a background for transport studies in drug-polymer systems.