gebhart/patrepeval huggingface dataset:
Wiener filter design using polynomial equations (1991)

A simplified way of deriving realizable and explicit Wiener filters is presented. Discrete-time problems are discussed in a polynomial equation framework. Optimal filters, predictors, and smoothers are calculated by means of spectral factorizations and linear polynomial equations. A tool for obtaining these equations, for a given problem structure, is described. It is based on the evaluation of orthogonality in the frequency domain, by means of canceling stable poles with zeros. Comparisons are made to previously known derivation methodologies such as completing the squares for the polynomial systems approach and the classical Wiener solution. The simplicity of the proposed derivation method is particularly evident in multistage filtering problems. To illustrate, two examples are discussed: a filtering and a generalized deconvolution problem. A new solvability condition for linear polynomial equation appearing in scalar problems is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Regulation of the Myeloid-Cell-Expressed Human gp91-phox Gene As Studied by Transfer of Yeast Artificial Chromosome Clones into Embryonic Stem Cells: Suppression of a Variegated Cellular Pattern of Expression Requires a Full Complement of Distant <i>cis</i> Elements (1997)

Identifying the full repertoire of cis elements required for gene expression in mammalian cells (or animals) is challenging, given the moderate sizes of many loci. To study how the human gp91-phox gene is expressed specifically in myeloid hematopoietic cells, we introduced yeast artificial chromosome (YAC) clones and derivatives generated in yeast into mouse embryonic stem cells competent to differentiate to myeloid cells in vitro or into mouse chimeras. Fully appropriate regulation was recapitulated with a 130-kb YAC containing 60 and 30 kb of 5' and 3' flanking sequences, respectively. Immunodetection of human gp91-phox protein revealed uniform expression in individual myeloid cells. The removal of upstream sequences led to decreased overall expression which reflected largely a variegated pattern of expression, such that cells were either "on" or "off," rather than pancellular loss of expression. The proportion of clones displaying marked variegation increased with progressive deletion. DNase I mapping of chromatin identified two hypersensitive clusters, consistent with the presence of multiple regulatory elements. Our findings point to cooperative interactions of complex regulatory elements and suggest that the presence of an incomplete set of elements reduces the probability that an open chromatin domain (or active transcriptional complex) may form or be maintained in the face of repressive influences of neighboring chromatin.
Crystal Structure of Thermotoga maritima 0065, a Member of the IclR Transcriptional Factor Family (2002)

Members of the IclR family of transcription regulators modulate signal-dependent expression of genes involved in carbon metabolism in bacteria and archaea. The Thermotoga maritima TM0065 gene codes for a protein (TM-IclR) that is homologous to the IclR family. We have determined the crystal structure of TM-IclR at 2.2 A resolution using MAD phasing and synchrotron radiation. The protein is composed of two domains: the N-terminal DNA-binding domain contains the winged helix-turn-helix motif, and the C-terminal presumed regulatory domain is involved in binding signal molecule. In a proposed signal-binding site, a bound Zn(2+) ion was found. In the crystal, TM-IclR forms a dimer through interactions between DNA-binding domains. In the dimer, the DNA-binding domains are 2-fold related, but the dimer is asymmetric with respect to the orientation of signal-binding domains. Crystal packing analysis showed that TM-IclR dimers form a tetramer through interactions exclusively by signal-binding domains. A model is proposed for binding of IclR-like factors to DNA, and it suggests that signal-dependent transcription regulation is accomplished by affecting an oligomerization state of IclR and therefore its affinity for DNA target.
Patterns of adherence to antiretroviral medications (2003)

This is the first report objectively to quantify intra-subject adherence to antiretroviral therapy and report the findings in detail. We observed clear patterns of drug-taking behavior among the subjects in our study. To the extent that medication scheduling is a controllable factor, our report provides an insight into specific patterns of behavior that may be targets for adherence counseling.
Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking β-catenin and cyclooxygenase-2 (2009)

Hepatocellular carcinoma (HCC) is a common human cancer with high mortality, and currently, there is no effective chemoprevention or systematic treatment. Recent evidence suggests that cyclooxygenase-2 (COX-2)-derived PGE(2) and Wnt/beta-catenin signaling pathways are implicated in hepatocarcinogenesis. Here, we report that omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) inhibit HCC growth through simultaneously inhibition of COX-2 and beta-catenin. DHA and EPA treatment resulted in a dose-dependent reduction of cell viability with cleavage of poly ADP ribose polymerase, caspase-3, and caspase-9 in three human HCC cell lines (Hep3B, Huh-7, HepG2). In contrast, AA, a omega-6 PUFA, exhibited no significant effect. DHA and EPA treatment caused dephosphorylation and thus activation of GSK-3beta, leading to beta-catenin degradation in Hep3B cells. The GSK-3beta inhibitor, LiCl, partially prevented DHA-induced beta-catenin protein degradation and apoptosis. Additionally, DHA induced the formation of beta-catenin/Axin/GSK-3beta binding complex, which serves as a parallel mechanism for beta-catenin degradation. Furthermore, DHA inhibited PGE(2) signaling through downregulation of COX-2 and upregulation of the COX-2 antagonist, 15-hydroxyprostaglandin dehydrogenase. Finally, the growth of HCC in vivo was significantly reduced when mouse HCCs (Hepa1-6) were inoculated into the Fat-1 transgenic mice, which express a Caenorhabditis elegans desaturase converting omega-6 to omega-3 PUFAs endogenously. These findings provide important preclinical evidence and molecular insight for utilization of omega-3 PUFAs for the chemoprevention and treatment of human HCC.
Role of Temperature in Controlling Performance of Photorefractive Organic Glasses (2003)

We present a detailed temperature-dependence study of dielectric, birefringent, conductive, and photorefractive (PR) properties of high-performance low-molecular weight organic glasses that contain 2-dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) derivatives. DCDHF organic glasses sensitized with C60 exhibit high two-beam coupling gain coefficients in the red-wavelength region. However, in the best performing DCDHF glasses at room temperature the PR dynamics are limited by slow molecular reorientation in the electric field. While orientational and, therefore, PR speed can be significantly improved by increasing the temperature above the glass-transition temperature of the material, the steady-state performance may worsen. Comprehensive study of the temperature dependence of various processes, which contribute to the PR effect in DCDHF glasses, clarifies the limiting factors and allows for optimization of the overall PR performance.
Fabrication of refractive index distributions in polymer using a photochemical reaction (2000)

We demonstrate that a photochemical reaction can create various distributions of refractive index in polymer. When the polymer containing a photochemically active material is irradiated by UV light, the photochemical reaction which breaks the π-conjugated system in the material and decreases its linear polarizability can reduce refractive index of the polymer. We prepared a PMMA film added DMAPN ((4-N,N-dimethylaminophenyl)-N′-phenylnitrone) with a rate of 23 wt % by use of spin coating. Electronic structural change of DMAPN and refractive indices of the film before and after UV irradiation were evaluated by UV absorption spectra and m-line method, respectively. The UV irradiation decreased λmax at 380 nm in the absorption spectra, which is attributed to nitrone, and the refractive indices exponentially with irradiation time. The change of refractive indices reached 0.028. The refractive index profile upon depth of the film was investigated by measuring refractive indices of stacked DMAPN/PMMA films. When UV with a power of 10.7 mW/cm2 irradiated upon three stacked DMAPN/PMMA films for 35 s, variation of the refractive index change showed a quadratic profile. The refractive index profile with various irradiation time can be accounted with the combination of the chemical kinetics with the steady state approximation and Lambert–Beer's law. Thus, the photochemical reaction can be used to control the refractive index distribution in polymer.
Cellular Integration of an Enzyme‐Loaded Polymersome Nanoreactor (2010)

Cells with implants: Porous enzyme-loaded polymersomes were constructed that display the cell-penetrating peptide tat on their surfaces. These nanoreactors are taken up by mammalian cells through macropinocytosis. Inside the cells, the polymersomes are only partially routed to acidic compartments. Polymersomes with horseradish peroxidase as a model cargo enzyme displayed sustained intracellular activity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of aluminum adjuvants on safety and immunogenicity of <i>Haemophilus influenzae</i> type b‐CRM<sub>197</sub> conjugate vaccine (2003)

The use of aluminum compounds adjuvants in Hib-CRM197 conjugate vaccines does not impact the safety profile, while it does increase the magnitude of anti-PRP antibody titers.
Silica Chloride as a Mild and Efficient Reagent for Acetylation of Alcohols (2003)

Abstract A variety of alcohols underwent acetylation with acetic anhydride in the presence of silica chloride. All reactions were performed at room temperature and under completely heterogeneous conditions in good to high yields. We appreciate the financial support of this work by the Guilan University Research Council. Keywords : Acetylationalcoholesterificationheterogeneous conditionssilica chloride Notes We appreciate the financial support of this work by the Guilan University Research Council.
Interaction between rifabutin and human immunodeficiency virus type 1: inhibition of replication, cytopathic effect, and reverse transcriptase in vitro (1988)

Rifabutin (ansamycin; LM427), a semisynthetic rifamycin derivative, inhibits the replication of human immunodeficiency virus type 1, the virus etiologically linked to acquired immunodeficiency syndrome. The inhibition of virus production was observed in human immunodeficiency virus type 1-infected peripheral blood mononuclear cells both by reverse transcriptase assay and virus-antigen assay. In addition, rifabutin effectively reduced human immunodeficiency virus type 1-associated cytopathic effect to OKT4-positive cells. Virion-associated reverse transcriptase was also markedly inhibited by rifabutin. The inhibitory dose of rifabutin was nontoxic to lymphoid cells, which further suggests that it might serve as a useful agent in the therapeutic modalities of acquired immunodeficiency syndrome.
Polymorphonuclear Leukocytes Prepared by Continuous-Flow Filtration Leukapheresis: Viability and Function (1974)

Abstract Preparation of granulocytes for transfusion in high yield and relatively free of contamination by other cell types has been made possible by the technique of continuous-flow filtration leukapheresis (CFFL). Since previous work suggested that granulocytes collected in this manner may have impaired viability and function, a detailed study of the bactericidal, metabolic, and chemotactic properties of such cells was performed and compared to control cells obtained from the same donors prior to CFFL. The granulocyte percentage of the cell suspensions obtained by CFFL averaged 94.5% ± 1.5% compared to 82.5% ± 1.8% for the controls (p < 0.001) with viability of the PMNs determined by trypan blue exclusion being 97.5% ± 0.9% and 98.2% ± 0.5%, respectively. The phogocytic, metabolic (14C-I-glucose oxidation and protein iodination) and chemotactic properties of both cell types were equivalent in suspensions equalized for granulocyte content. These findings indicate that CFFL technique employed does not impair granulocyte viability or function in vitro. Studies of the in vivo survival and function of CFFL granulocytes are necessary to evaluate their efficacy in combating infection in severely leukopenic patients.
Anomaly detection in VoIP traffic with trends (2012)

In this paper we present methodological advances in anomaly detection, which, among other purposes, can be used to discover abnormal traffic patterns under the presence of deterministic trends in data, given that specific assumptions about the traffic type and nature are met. A performance study of the proposed methods, both if these assumptions are fulfilled and violated, shows good results in great generality. Our study features VoIP call counts, but the methodology can be applied to any data following, at least roughly, a non-homogeneous Poisson process (think of highly aggregated traffic flows).
Intracellular delivery of antibodies by chimeric Sesbania mosaic virus (SeMV) virus like particles (2016)

The therapeutic potential of antibodies has not been fully exploited as they fail to cross cell membrane. In this article, we have tested the possibility of using plant virus based nanoparticles for intracellular delivery of antibodies. For this purpose, Sesbania mosaic virus coat protein (CP) was genetically engineered with the B domain of Staphylococcus aureus protein A (SpA) at the βH-βI loop, to generate SeMV loop B (SLB), which self-assembled to virus like particles (VLPs) with 43 times higher affinity towards antibodies. CP and SLB could internalize into various types of mammalian cells and SLB could efficiently deliver three different monoclonal antibodies-D6F10 (targeting abrin), anti-α-tubulin (targeting intracellular tubulin) and Herclon (against HER2 receptor) inside the cells. Such a mode of delivery was much more effective than antibodies alone treatment. These results highlight the potential of SLB as a universal nanocarrier for intracellular delivery of antibodies.
Cyclosporine blocks muscle differentiation by inducing oxidative stress and by inhibiting the peptidylprolyl‐cistrans‐isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporine‐induced cytotoxicity (2002)

Allogenic myoblast transplantation (AMT) is under investigation for treatment of severe genetic myopathies. Data regarding the role of cyclosporine (CsA) and FK-506 in AMT have shown that CsA is less effective than FK-506. For this study, we investigated mechanisms of CsA toxicity during AMT and showed that a high level of reactive oxygen species (ROS) generated by CsA, mediated partly by inhibition of the peptidylprolyl-cis-trans-isomerase (PPIase)-like activity of cyclophilin A (CypA), blocked differentiation and induced apoptosis at an early stage of muscle differentiation. Inhibition of the PPIase-like activity of CypA alone also blocked muscle differentiation. However, CsA toxicity did not depend on the inhibition of calcineurin activity during muscle differentiation. Together, these data suggest that CsA-mediated inhibition of the PPIase-like activity of CypA and the high level of ROS generation contributed to the low efficacy of CsA in AMT. In addition, we showed that a reduction of oxidative stress protected cells from CsA-induced apoptosis, and myoblasts that had survived after preexposure to CsA not only proliferated and differentiated reversibly but also gained resistance to subsequent CsA exposure. Thus, administration of antioxidants or overexpression of CypA either exogenously or endogenously during CsA treatment has the potential to improve the success of this treatment in AMT.
Effect of a weak donor on the intramolecular charge transfer of molecules containing two neighboring silicon atoms (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of a weak donor on the intramolecular charge transfer of molecules containing two neighboring silicon atomsG. Mignani, A. Kramer, G. Puccetti, I. Ledoux, J. Zyss, and G. SoulaCite this: Organometallics 1991, 10, 10, 3656–3659Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/om00056a042https://doi.org/10.1021/om00056a042research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complexes control nitric oxide release (1992)

RETURN TO ISSUEPREVNewsNEXTComplexes control nitric oxide releaseRUDY BAUMCite this: Chem. Eng. News 1992, 70, 37, 32–33Publication Date (Print):September 14, 1992Publication History Published online10 November 2010Published inissue 14 September 1992https://pubs.acs.org/doi/10.1021/cen-v070n037.p032https://doi.org/10.1021/cen-v070n037.p032newsACS PublicationsCopyright © 1992 American Chemical SocietyArticle Views17Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Oxides Get e-Alerts
A Smart Filtering System for Newly Coined Profanities by Using Approximate String Alignment (2010)

Verbal abuse is becoming a serious social problem in online communication, because anonymity makes it easier to use profanities. Detecting and removing some words that have been registered in a forbidden list is a straightforward filtering method. This is simple, but preparing the forbidden word list is difficult as newly coined words have to be added to the lexicon. Especially Korean is a type of agglutinative language, so the construction of new variations of a vulgar word is easy without causing difficulties in textual communications in an online environment. In this paper we propose a new method to detect all variations of a vulgar word with phoneme modification by applying a phoneme based string alignment. However, aligning a query word against all vulgar words registered in a database takes time and its computation is difficult. We propose a R*-tree based searching algorithm to overcome this expensive computation. The method applies the metric space property of string edit distance. We prepared a word database with more than 9300 prototype vulgar words for experiment. For a given query word, our algorithm quickly finds the best-aligned candidate word(0.006 sec. with 1000 words), which are within an edit distance equals of one unit. Our contribution is that we empirically found the number of pivot words to create a near optimal searching space.
Winding Changeover Permanent-Magnet Generators for Renewable Energy Applications (2012)

This paper reports on the development of a permanent-magnet (PM) generator for a wind turbine which has variable winding connections for load matching. This means that the generator characteristics can be regulated via winding changeover so that the wind turbine can be controlled and maximum power point tacking (MPPT) followed; constant power output is possible without pitch control, complex algorithms or expensive power converters. The operating range (up to the cut-out point) can be extended into the high wind speed zone without drawing high power from the wind. This is achieved by maintaining the generator at the rated power when the wind speed increases beyond the rated point. Therefore, the specifications and costs of the generator and power electronics can be reduced. Experiments are conducted to demonstrate the effectiveness of the presented method.
Stacked patches with a slot in the common wall for single- and dual-band operation (1992)

A two-stacked-patch configuration is considered in which the coupling region is moved from the edges to the center by cutting a slot in the lower patch. Measurements show that, under certain conditions, the coupling between the patches is mainly governed by the slot length, which can be easily adjusted to provide different levels of coupling and hence different values of the ratio f/sub 1//f/sub 2/ of the two resonance frequencies. This approach has been used to achieve antenna designs with both small ratio for moderate enhancement of bandwidth and relatively large ratio between center frequencies (f/sub L1//f/sub L2/=1.3) of a dual-band antenna for the Global Positioning System. Experimental results show that the ratio between the two resonances of a stacked patch antenna can be easily controlled with a slot in the lower patch provided that the slot is the major source of coupling between the patches. For electrically thin antennas, this configuration has the advantage of lending itself to analysis methods based on the cavity model or using a 2-D Green's function such as the boundary integral method.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>