gebhart/patrepeval huggingface dataset:
A fibrinogen receptor from group B <i>Streptococcus</i> interacts with fibrinogen by repetitive units with novel ligand binding sites (2002)

Group B Streptococcus (GBS) is a frequent cause of bacterial sepsis and meningitis in neonates. During the course of infection, GBS colonizes and invades a number of host compartments, thereby interacting with different host proteins. In the present report, we describe the isolation of the fbsA gene, which encodes a fibrinogen receptor from GBS. The deduced FbsA protein is characterized by repetitive units, each 16 amino acids in length. Sequencing of the fbsA gene from five different GBS strains revealed significant variation in the number of repeat-encoding units. The deletion of the fbsA gene in the genome of GBS 6313 completely abolished fibrinogen binding, suggesting that FbsA is the major fibrinogen receptor in this strain. Growth of the fbsA deletion mutant in human blood was significantly impaired, indicating that FbsA protects GBS from opsonophagocytosis. In Western blot experiments with truncated FbsA -proteins, the repeat region of FbsA was identified as mediating fibrinogen binding. Using synthetic peptides, even a single repeat unit of FbsA was demonstrated to bind to fibrinogen. Spot membrane analysis and competitive binding experiments with peptides carrying single amino acid substitutions allowed the prediction of a fibrinogen-binding motif with the consensus sequence G-N/S/T-V-L-A/E/M/Q-R-R-X-K/R/W-A/D/E/N/Q-A/F/I/L/V/Y-X-X-K/R-X-X.
Templated Organic Synthesis (1999)

Templates in supramolecular chemistry: 1. Templates in organic synthesis - definitions and roles, H. Anderson molecular imprinting - templated materials for recognition and catalysis, G. Wulff templated synthesis of catenanes and rotaxanes, J.F. Stoddart templated synthesis of carcerands, containers, and capsules, J.C. Sherman) self-replicating systems, R. Ghadiri template-directed nucleic acid synthesis, D.G. Lynn templates in organic synthesis - tether-directed remote functionalization, R. Breslow regio- and stereoselective multiple functionalization of fullerenes, F. Diederich template-controlled oligomerizations, K.S. Feldman and N. Porter templated ring-closing reactions, A. Fnrstner templated stereoselective synthesis using remote covalent tethers, S.V. Ley substrate-directed chemical reactions, A. Hoveyda.
Optimization-Based Islanding of Power Networks Using Piecewise Linear AC Power Flow (2014)

In this paper, a flexible optimization-based framework for intentional islanding is presented. The decision is made of which transmission lines to switch in order to split the network while minimizing disruption, the amount of load shed, or grouping coherent generators. The approach uses a piecewise linear model of AC power flow, which allows the voltage and reactive power to be considered directly when designing the islands. Demonstrations on standard test networks show that solution of the problem provides islands that are balanced in real and reactive power, satisfy AC power flow laws, and have a healthy voltage profile.
THE EFFECT OF UNILATERAL OVARIECTOMY ON THE REPRODUCTIVE LIFESPAN OF MICE (1960)

SUMMARY Although unilaterally spayed mice can produce litters almost as large as those produced by normal mice, their reproductive lifespan is curtailed and the total number of offspring born is about halved.
The effects of dynamic saddle annulus and leaflet length on transmitral flow pattern and leaflet stress of a bileaflet bioprosthetic mitral valve. (2012)

Motion of the mitral saddle annulus along with the leaflet length is a critical factor that minimizes stress distribution at the tips of the leaflets due to a dampening of the pressure load exerted over the valve during the cardiac cycle. The length of the leaflets, and their proximity to the ventricular wall, have been shown to have significant effects on transmitral vortex formation and energy dissipation during blood transfer from the left atrium towards the aorta via left ventricle.
High performance 3D MCM using silicon microtechnologies (2002)

Future applications will require a higher I/O count, more densification, greater performance and lower cost. The Multichip Modules (MCM) offer this technical potential and possible lower cost for the global system. Three dimensional (3D) packaging is another technique that provides size and performance benefits. This paper describes a 3D structure developed in LETI with microtechnologies in and on silicon substrates. This 3D-MCM made from 2D-MCM/D technology offers a lot of advantages in terms of electrical and thermal performance. A large application field in microelectronics is ready for mass memory modules or parallel processor computers and also in microsystems where different technologies have to be closely interconnected. A technology demonstrator is presented, the chosen application is a 1-Gbit mass memory module which contains 64/spl times/16 Mbit DRAMs interconnected on 8-stacked MCMs.
Biomechanical and histomorphometric comparison between zirconia implants with varying surface textures and a titanium implant in the maxilla of miniature pigs (2007)

The findings suggest that ZrO2r implants can achieve a higher stability in bone than ZrO2m implants. Roughening the turned zirconia implants enhances bone apposition and has a beneficial effect on the interfacial shear strength.
Studies on the metabolites of Verticillium sp. Structures of verticillins A, B, and C (1973)

Three new antibiotics, verticillins A (Ia), B (XVIII), and C have been isolated from Verticillium sp. Stereo-structures of verticillins A and B, which are derivatives of bi-(3,11 a-epidithio-1.4-dioxopyrazino[1′,2′ : 1,5]pyrrolo-[2,3-b]indol-10b-yl), have been elucidated by chemical and physicochemical methods. Verticillin C is thought to be an epitrithio-analogue of verticillin B.
The Procedure for Determining and Quality Assurance Program for the Calculation of Dose Coefficients Using DCAL Software (2001)

The development of a spallation neutron source with a mercury target may lead to the production of rare radionuclides. The dose coefficients for many of these radionuclides have not yet been published. A collaboration of universities and national labs has taken on the task of calculating dose coefficients for the rare radionuclides using the software package: DCAL. The working group developed a procedure for calculating dose coefficients and a quality assurance (QA) program to verify the calculations completed. The first portion of this QA program was to verify that each participating group could independently reproduce the dose coefficients for a known set of radionuclides. The second effort was to divide the group of radionuclides among the independent participants in a manner that assured that each radionuclide would be redundantly and independently calculated. The final aspect of this program was to resolve any discrepancies arising among the participants as a group of the whole. The output of the various software programs for six QA radionuclides, 144Nd, 201Au, 50V, 61Co, 41Ar, and 38S were compared among all members of the working group. Initially, a few differences in outputs were identified. This exercise identified weaknesses in the procedure, which have since been revised. After the revisions, dose coefficients were calculated and compared to published dose coefficients with good agreement. The present efforts involve generating dose coefficients for the rare radionuclides anticipated to be produced from the spallation neutron source should a mercury target be employed.
Monocular Depth Estimation with Augmented Ordinal Depth Relationships (2018)

Most existing algorithms for depth estimation from single monocular images need large quantities of metric groundtruth depths for supervised learning. We show that relative depth can be an informative cue for metric depth estimation and can be easily obtained from vast stereo videos. Acquiring metric depths from stereo videos is sometimes impracticable due to the absence of camera parameters. In this paper, we propose to improve the performance of metric depth estimation with relative depths collected from stereo movie videos using existing stereo matching algorithm.We introduce a new "Relative Depth in Stereo" (RDIS) dataset densely labelled with relative depths. We first pretrain a ResNet model on our RDIS dataset. Then we finetune the model on RGB-D datasets with metric ground-truth depths. During our finetuning, we formulate depth estimation as a classification task. This re-formulation scheme enables us to obtain the confidence of a depth prediction in the form of probability distribution. With this confidence, we propose an information gain loss to make use of the predictions that are close to ground-truth. We evaluate our approach on both indoor and outdoor benchmark RGB-D datasets and achieve state-of-the-art performance.
Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor (2001)

Oligonucleotides (ODNs) can be employed as effective gene-specific regulators. However, before ODNs can reach their targets, several physical barriers have to be overcome, as although ODNs may pass cell membranes, most become sequestered in endocytic compartments. Accordingly, sophisticated strategies are required for efficient delivery. Here we have employed a pyridinium-based synthetic amphiphile, called SAINT-2, which carries ODNs into cells in a highly efficient, essentially non-toxic and serum-insensitive manner. Intracellular delivery was examined by monitoring the trafficking of fluorescent ODNs and lipid, and by measuring the effect of specific antisense ODNs on target mRNA and protein levels of the receptor for the neuropeptide corticotropin-releasing factor (CRF-R), expressed in Chinese hamster ovary cells. ODN delivery is independent of lipoplex size, and fluorescently tagged ODNs readily acquire access to the nucleus, whereas the carrier itself remains sequestered in the endosomal-lysosomal pathway. While the release is independent of the presence of serum, it is not observed when serum proteins gain access within the lipoplex, and which likely stabilizes the lipoplex membrane. We propose that the amphiphile-dependent aggregate structure governs complex dissociation, and hence, the biological efficiency of ODNS: We demonstrate an essentially non-toxic and effective antisense-specific down-regulation of the CRF-R, both at the mRNA and protein level.
Serum IgA Antibodies from Patients with Coeliac Disease React Strongly with Human Brain Blood-Vessel Structures (1998)

Sera from patients with active CD contain IgA antibodies that react with human brain vessel structures, giving intense fluorescence. These antibodies are not present in sera from coeliac patients on a GFD or non-coeliac controls. This finding might be involved in the abnormal nervous system manifestations frequently described in association with coeliac disease.
Determination of Young’s Modulus of Porous Low-k Films by Ellipsometric Porosimetry (2002)

A method for determination of Young's modulus (E) of thin porous films using data obtained by ellipsometric porosimetry (EP) is reported. The calculated E values are in good agreement with data obtained by nondestructive methods like surface acoustic wave spectroscopy (SAWS) and Brillouin light scattering (BLS). These three methods (SAWS, BLS, and EP) use different physical ideas for determination of Young's modulus. Good agreement among these data suggests that the obtained data are more realistic than data obtained by nanoindentation that gives remarkably larger E values. © 2002 The Electrochemical Society. All rights reserved.
Improved multilook technique applied to SAR images (2002)

The multilook technique used in synthetic aperture radar image formation consists of adding incoherently M looks. As these looks can be obtained in their complex form and are correlated, the phase and correlation information should be taken into account in the speckle reduction process. We propose an improved multilook technique based on the use of these two information. We apply it to SAR images displaying ship wakes. Our technique consists of enhancing a specific texture in the image, using a set of filters matched to it, while simultaneously reducing the speckle. The filters are applied on each look, and the resulting images are projected onto a particular basis. The final image is constituted by the quadratic sum of the processed looks, after their projection on the same geographic plane. The illustrative results of image comparison and analysis show the effectiveness of the proposed algorithm.
Synthesis of Novel Unsymmetrically Substituted Push-Pull Phthalocyanines (1996)

The synthesis and characterization of novel non-centrosymmetrically push-pull substituted metal-free phthalocyanines 3−9 are described. The compounds have different donor (dialkoxy, tert-butyl, methyl, p-tolylthio) and/or attractor (p-tolylsulfinyl, p-tolylsulfonyl, nitro) functional groups, are soluble in organic solvents, and are especially designed to study their second- and third-order nonlinear optical properties. Compounds 7−9 are mixtures of the four corresponding regioisomers. For preparing the unsymmetrical phthalocyanines 7−9, the effectiveness of the subphthalocyanine route, using different substituted diiminoisoindolines as reagents, has been tested. Furthermore, a comparison between this method versus the statistical one has been done. The results obtained show that the ring enlargement reaction of subphthalocyanines to obtain unsymmetrically substituted phthalocyanines is not a selective reaction but a multistep process, which depends dramatically on the nature of the substituents on the subphthalocyanines, the reactivity of the iminoisoindoline, the solvent, and other factors that limit its general synthetic utility. Preliminary data of the experimental second-order hyperpolarizabilities of compounds 3−9 are also given.
An in vivo Experimental System to Study Sugar Phloem Unloading in Ripening Grape Berries During Water Deficiency Stress (2003)

An in vivo experimental system-called the 'berry-cup' technique-was developed to study sugar phloem unloading and the accumulation of sugar in ripening grape berries. The berry-cup system consists of a single peeled grape berry immersed in a buffer solution in a cup prepared from a polypropylene syringe. A small cross-incision (2 mm in length) is made on the stylar remnant of a berry during its ripening phase, the skin of the berry then being easily peeled off, exposing the dorsal vascular bundles without damaging either these or the pulp tissue of the berry. The sites of sugar phloem unloading are thus made directly accessible and may be regulated by the buffer solution. In addition, the unloaded photoassimilates are easily transported into the buffer solution in the berry-cup. With the berry-cup technique, it takes 60 min to purge the sugar already present in the apoplast, after which the amount of sugar in the buffer solution is a direct measure of the sugar unloading from the grape berry phloem. The optimum times for sampling were 20 or 30 min, depending on the type of experiment. Sugar phloem unloading was significantly inhibited by the inclusion of either 7.5 mm NaF or 2.5 mm PCMB in the buffer solution. This study indicates that sugar phloem unloading in ripening grape berries is via the apoplastic network and that the process requires the input of energy. The system was shown to be an appropriate experimental system with which to study sugar phloem unloading in ripening grape berries, and was applied successfully to the study of berry sugar unloaded from grapevines subjected to water stress. The results showed that water deficiency inhibits sugar unloading in grape berries.
Bioinspired architecture approach for a one-billion transistor smart CMOS camera chip (2007)

In the paper we present a massively parallel VLSI architecture for future smart CMOS camera chips with up to one billion transistors. To exploit efficiently the potential offered by future micro- or nanoelectronic devices traditional on central structures oriented parallel architectures based on MIMD or SIMD approaches will fail. They require too long and too many global interconnects for the distribution of code or the access to common memory. On the other hand nature developed self-organising and emergent principles to manage successfully complex structures based on lots of interacting simple elements. Therefore we developed a new as Marching Pixels denoted emergent computing paradigm based on a mixture of bio-inspired computing models like cellular automaton and artificial ants. In the paper we present different Marching Pixels algorithms and the corresponding VLSI array architecture. A detailed synthesis result for a 0.18 &mgr;m CMOS process shows that a 256×256 pixel image is processed in less than 10 ms assuming a moderate 100 MHz clock rate for the processor array. Future higher integration densities and a 3D chip stacking technology will allow the integration and processing of Mega pixels within the same time since our architecture is fully scalable.
Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-Stimulated <sup>32</sup>P<sub>i</sub> Incorporation into Phospholipids and Protein Phosphorylation by 2,7, 11-Cembratriene-4,6-Diol, an Antitumor-Promoting Agent (1988)

A possible mechanism of antitumor-promoting activity of alpha-2,7,11-cembratriene-4,6-diol (alpha-CBT) was studied. alpha-CBT inhibited the 32Pi incorporation into phospholipids of HeLa cells stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA). In contrast to the property to interact with calmodulin of many other antitumor-promoting agents, which were proved to inhibit TPA-stimulated 32Pi incorporation into phospholipids, alpha-CBT did not show any interaction with calmodulin; i.e., the fluorescence of N-phenyl-1-naphthylamine enhanced by binding with Ca2+-calmodulin was not influenced by treatment with alpha-CBT. TPA-stimulated phosphorylation of 47-kilodalton protein, which is phosphorylated by protein kinase C in human platelets, was found to be inhibited by alpha-CBT. However, the specific binding of 3H-TPA to mouse epidermal particulate fraction was not inhibited by treatment with alpha-CBT. These results suggest that alpha-CBT inhibits the activity of protein kinase C by another mode of action rather than the effect on its receptor site, and that this action and calmodulin-independent inhibitory effect on phospholipid metabolism of alpha-CBT may play a certain role in its antitumor-promoting activity in vivo.
Routing solution for VoIP calls in large-scale IP MM networks (2004)

BGCF is a mandatory function in large-scale IP multimedia networks that inter-works with PSTN and standardised by the 3GPP release 6. This document describes the system architecture of the BGCF prototype with an aim to become a foundation for future real and commercial BGCF system.
The Explicit Quad Tree as a Structure for Computer Graphics (1982)

A quad tree, stored without links and with a location for every possible node, is proposed as a structure for holding an image under construction. In this form, picture coherence is not exploited to reduce storage requirements, but to improve the speed of interrogation and modification. Basic operations on this structure are outlined, and an efficient addressing scheme presented.
Efficient method for a one-carbon homologation of aldehydes and benzophenone to carboxylic acids (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient method for a one-carbon homologation of aldehydes and benzophenone to carboxylic acidsKazumasa Takahashi, Kenichiro Shibasaki, Katsuyuki Ogura, and Hirotada IidaCite this: J. Org. Chem. 1983, 48, 20, 3566–3569Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/jo00168a042https://doi.org/10.1021/jo00168a042research-articleACS PublicationsRequest reuse permissionsArticle Views1100Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reversal in stereoselectivity depending upon the age of a chiral lithium alkoxyaluminohydride reducing agent (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversal in stereoselectivity depending upon the age of a chiral lithium alkoxyaluminohydride reducing agentS. Yamaguchi, Harry S. Mosher, and A. PohlandCite this: J. Am. Chem. Soc. 1972, 94, 26, 9254–9255Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/ja00781a060https://doi.org/10.1021/ja00781a060research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts