gebhart/patrepeval huggingface dataset:
Mutanase of Paenibacillus humicus from Fermented Food Has a Potential for Hydrolysis of Biofilms Synthesized by Streptococcus mutans (2011)

Mutanase is an α-1,3-glucanase that cleaves the α-1,3-glucosidic linkages of glucan polysaccharides termed mutan. There has been interest in mutanase as it has the potential to be considered in preventive medicine. Previously, we identified the mutanase of Paenibacillus humicus from fermented soybeans and observed that the enzyme hydrolyzed insoluble glucans and mutan in vitro. Here we focused on the ability of mutanase in preventing dental caries. We proposed that the enzyme participates in the degradation of insoluble glucan biofilms in microplates, which were used as a model of biofilms on tooth surface. In this study, we investigated the potential of mutanase to hydrolyze insoluble glucan biofilms synthesized by a typical cariogenic streptococcus, Streptococcus mutans 10449, in 96-well microplates. The mutanase specifically hydrolyzed insoluble glucan biofilms composed of insoluble glucans synthesized by S. mutans. The mutanase hydrolyzed approximately 60% of S. mutans glucan biofilms in the wells and liberated oligosaccharides from the glucan films. We observed that recombinant mutanase could hydrolyze mutan biofilms, and the enzyme was characterized as an endo-α-1,3-glucanase because its hydrolysis of mutan biofilms, resulted in the predominant liberation of α-1,3-glucan tetrasaccharides. The present study suggests that Paenibacillus mutanase from fermented soybeans has potential application in preventive medicine because of its ability to degrade oral insoluble glucan biofilms.
Fiber Bragg distributed chemical sensor (2011)

A distributed chemical sensor is developed by coating multiple Bragg gratings in a single glass fiber with chemical responsive coatings. The composition of the coating is tuned to the target chemicals to be measured and the optical response of the coated grating is optimized by changing the coating thickness. Specific recoaters were used to apply the responsive coatings reproducibly onto the glass fibers. The coating compositions can be based on UV curing or solvent based systems. In this paper we show the development and application of a distributed gas sensor for CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> S and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O that can be used for down-hole monitoring in the oil and gas industry. We have developed a toolbox for the design and modeling of the responsive polymer coatings, and the performance of the actual sensors corresponded well with the predicted behavior.
Excellent threshold switching device (I<inf>off</inf> ∼ 1 pA) with atom-scale metal filament for steep slope (< 5 mV/dec), ultra low voltage (V<inf>dd</inf> = 0.25 V) FET applications (2016)

To realize a steep-slope-FET with low leakage current and low operating bias, we engineered two types of atom-switch devices and integrated them with a silicon MOSFET. The integrated atom-switch-FET exhibits extremely low leakage current (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-7</sup> μA/μm), high I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ratio (> 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> ), low operating bias (<; 1 V) and sub-5 mV/dec subthreshold swing with abrupt transition range of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> . Furthermore, through the comprehensive understanding on the steep-slope-transition phenomenon, control parameters of atom-switch devices such as R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> and Vth, as for optimal performances of atom-switch-FET were investigated at various operating bias conditions.
Matlab simulation interface for locomotion analysis of a hexapod robot structure (2012)

In this paper the authors presents a software platform for controlling a virtual hexapod robot made using Matlab. The interface allows full control of the hexapod robot, hardware and software single leg control and locomotion control over obstacles. The main purpose of the interface is to simulate hexapod robot locomotion over common obstacles types. The model of the robot and the leg were developed using geometrical modeling based on Denavit-Hartenberg algorithm. The leg control part is an experimental one and it is a combination between Matlab and Arduino Mega 2560 development board. In order to control the robotic leg the direct kinematics model and inverse kinematics model were used. The application consists of moving the leg tip along a predefined trajectory using a walking algorithm. Moving the leg tip from one point to another is made in two steps: stance phase and swing phase. The paper includes some simulation results related to the locomotion over common obstacles types.
Necessary and sufficient conditions for the existence of totally self-checking circuits (2004)

In this paper, concurrent checking by use of a complementary circuit for an 1-out-of-n code is investigated. For an arbitrarily given combinational circuit, necessary and sufficient conditions for the existence of a totally self-checking checker are derived for the first time.
Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country (2013)

In low TB prevalence settings, the QFT-IT yields more positive and fewer indeterminate results than T-SPOT.TB. Negative results on the QFT-IT and indeterminate/unavailable results on the T-SPOT.TB were more common in individuals with low CD4+ T-cell counts.
Rapid determination of phytanic acid in human blood serum by selectivity tuning in packed column SFC (1993)

Abstract A new packed column SFC method has been developed for the determination of phytanic acid in human blood serum. Because of the low viscosity and high diffusion coefficient of supercritical carbon dioxide, several columns can be connected in series, significantly improving separation. Series connection of columns which differ in their selectivity enables the adjustment of the total selectivity towards the individual separation problem (‘selectivity tuning’). In this instance it was possible, after transesterification into their ethyl esters, to separate all the fatty acids in human blood serum, including phytanic acid, by coupling three columns (silica, amino‐propyl, and RP8) in series.
Carbonylative coupling of an amino acid-derived organozinc reagent with functionalized aryl iodides: synthesis of kynurenine (1995)

The utility of the palladium(0) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo α-amino acids 8 is illustrated by a short synthesis of L-kynurenine.
Monoclonal Antibody Against Human Growth Hormone Receptor (2000)

GHR shows a high degree of homology with the prolactin receptor and with the other receptors that belong to the hemopoietic receptor superfamily. This paper describes a monoclonal antibody (MAb) (2B4B6) specific for both the extracellular domain of human GHR and human growth hormone (GH) binding protein. Mice were immunized against a seven-aminoacid peptide sequence screened by FASTA (sequence similarity search served by Genome-Net) from the European Bioinformatics Institute to exclude the existence of human membrane proteins with significant sequence homology. MAbs were screened against the peptide sequence and 2B4B6 was selected for its capability to recognize the full-length hGHBP. As evaluated by both enzyme-linked immunoadsorbent assay (ELISA) and FACS analysis, this MAb seems to recognize and bind to a hGHR positive cell line, IM-9, as well as a murine cell line, BaF3 (8/6), transfected with a chimeric construct, hGHR/hG-CSFR and expressing hGHR on the cell membrane. Studies investigating the biological effects of this MAb showed that anti-hGHR mediated inhibition of cell proliferation was not due to competition with GH binding but rather to prevention of receptor dimerization. Because of its specificity, this MAb may be usefully applied in situations in which GHR and receptors with a high degree of homology, such as PRLR (prolactin receptor), are expressed simultaneously, as occurs in the immune system.
Multiple Sclerosis and Oral Care (2002)

Multiple sclerosis is a complex neurological condition affecting sensory and motor nerve transmission. Its progression and symptoms are unpredictable and vary from person to person as well as over time. Common early symptoms include visual disturbances, facial pain or trigeminal neuralgia and paraesthesia or numbness of feet, legs, hands and arms. These, plus symptoms of spasticity, spasms, tremor, fatigue, depression and progressive disability, impact on the individual's ability to maintain oral health, cope with dental treatment and access dental services. Also, many of the medications used in the symptomatic management of the condition have the potential to cause dry mouth and associated oral disease. There is no cure for multiple sclerosis, and treatment focuses on prevention of disability and maintenance of quality of life. Increasingly a multi-disciplinary team approach is used where the individual, if appropriate his/her carer, and the specialist nurse are key figures. The dental team plays an essential role in ensuring that oral health impacts positively on general health.
An improved method of sample preparation on AnchorChip™ targets for MALDI‐MS and MS/MS and its application in the liver proteome project (2007)

An improved method for sample preparation for MALDI-MS and MS/MS using AnchorChip targets is presented. The method, termed the SMW method (sample, matrix wash), results in better sensitivity for peptide mass fingerprinting as well as for sequencing by MS/MS than previously published methods. The method allows up-concentration and desalting directly on the mass spectrometric target and should be amenable for automation. A draw back caused by extensive oxidation of methionine and tryptophan in the SMW method can be alleviated by the addition of n-octyl glucopyranoside and DTT to the sample solution. The method was validated for protein identification from a 2-DE based liver proteome study. The SMW method resulted in identification of many more proteins and in most cases with a better score than the previously published methods.
Expert Systems Research (1983)

Artificial intelligence, long a topic of basic computer science research, is now being applied to problems of scientific, technical, and commercial interest. Some consultation programs, although limited in versatility, have achieved levels of performance rivaling those of human experts. A collateral benefit of this work is the systematization of previously unformalized knowledge in areas such as medical diagnosis and geology.
Analysis of the Frequency of MHC-Unrestricted MUC1 -Specific CytotoxicT-Cells in Peripheral Blood by Limiting Dilution Assay (2000)

Mucins are highly glycosylated proteins present on the lumenal side of ductal epithelial cells. MUC1 is the only mucin with a transmembrane region anchoring it to the cell surface. The extracellular domain of MUC1 is composed of numerous tandem repeats of a 20-amino acid sequence (1). Normal cells produce a highly glycosylated and sialylated form of MUC1. The O-linked carbohydrate side chains of MUC1 on tumor cells are shorter and less abundant, exposing previously unrecognized antigenic sites on the polypeptide core of the molecule (2). This underglycosylated MUC1 molecule on tumor cells can be recognized as a tumor-specific antigen by T-cells. The major cytotoxic T-lymphocyte (CTL) response to tumor-specific MUC1 is T-cell receptor (TCR) mediated but major histocompatibility complex (MHC)-unrestricted. Owing to the high density of repeating antigenic epitopes extending along each MUC1 molecule, it is postulated that a large number of TCRs can be triggered simultaneously to activate the CTLs to kill tumor cells or proliferate (3–5). Antibodies specific for the TCR, or for the defined MUC1 epitope recognized by the TCR, inhibit CTL recognition. Antibodies against MHC molecules have no effect.
Data-Fusion of PMD-Based Distance-Information and High-Resolution RGB-Images (2007)

An important field of reasearch in computer vision is the 3D analysis and reconstruction of objects and scenes for e.g. position determination, online object recognition or collision prevention. Known techniques thereby mainly rely on measuring devices such as laser scanners, stereo camera systems, or comparable algorithms like structure from motion. The rather new Photonic Mixing Device (PMD) technique is based on the time-of-flight principle and measures full-range distance information in real-time. Unfortunately, PMD-based devices have still limited resolution (e.g. 160 x 120px) and provide only graylevel information. This paper describes a fast algorithmic approach to combine high resolution RGB images with low resolution PMD distance data, acquired using a binocular camera setup. The approach relies completely on fast parallel Graphics Processing Units (GPUs) ressources. Additionally, we introduce a simple but efficient method to detect insufficient color assignments, which are due to the binocular setup. The resulting combined RGBZ-data not only enhances the visual result, but also represents a basis for advanced data processing in e.g. object recognition.
Relationship of<i>Campylobacter</i>Toxigenicity In Vitro to the Development of Postinfectious Irritable Bowel Syndrome (2001)

Campylobacter enteritis is associated with a significant risk of developing irritable bowel syndrome, but the mechanism is unknown. This study ascertained bowel symptoms in 93 patients 3 months after Campylobacter jejuni enteritis infection. The infecting organisms were cultured, and the effects of culture supernatants on toxin-sensitive epithelial cell monolayers (HEp-2, Green monkey kidney epithelial [Vero], and CHO-K1) were investigated. In all, 50, 43, and 41 of the isolates showed toxigenic effects on HEp-2, CHO-K1, and Vero cells, respectively. Persistently changed bowel habit was reported by 9 of 50 persons with HEp-2 toxin-positive infections but by only 2 of 43 with isolates negative for toxin (chi2=4.0; P<.05). Toxicity to HEp-2 and Vero cells was associated with significantly increased numbers of days with loose stools 6 months after C. jejuni enteritis infection (both, P<.05). Thus, long-term symptoms that occur Campylobacter infection are significantly associated with bacterial toxicity.
Guaranteed scrambling (2005)

The bit-error rate (BER) of a storage or transmission channel may be data-dependent. This can lead to certain pathological input sequences, for which the reliability of the system is below specifications. Guided scrambling is a well-known technique to randomize the input to a channel while minimizing a certain objective function. In this paper, we take the average predicted BER as the objective function. We show that for a certain scrambling code C, for any input sequence m there exists a scrambling codeword c/spl isin/C such that the predicted BER of the (modulo-2) sum of m and c is not more than that for random input data. We present examples of scrambling codes for two-dimensional optical storage and indicate a way of combining them with error-correcting codes.
Magnetic fields near overhead distribution lines-measurements and estimating technique (1991)

Measurements and analysis of magnetic fields in the vicinity of 51 separate overhead distribution lines are summarized. Data obtained covered a wide range of loads up to nearly 300 A. Results of measurements and correlation between the magnetic field and the phase currents at various distances from the line are discussed. A method of estimating the magnetic field exposure based on the load history of the distribution circuits is presented. A good correlation between the maximum primary current and the magnetic field at lateral distances within 15 m from the centerline was obtained. Near secondaries and service drops, magnetic fields generally decrease with increasing distances. A weak relationship between magnetic fields and conductor currents was found for secondaries and service drops.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Modeling the amide I bands of small peptides (2006)

In this paper different floating oscillator models for describing the amide I band of peptides and proteins are compared with density functional theory (DFT) calculations. Models for the variation of the frequency shifts of the oscillators and the nearest-neighbor coupling between them with respect to conformation are constructed from DFT normal mode calculations on N-acetyl-glycine-N(')-methylamide. The calculated frequencies are compared with those obtained from existing electrostatic models. Furthermore, a new transition charge coupling model is presented. We suggest a model which combines the nearest-neighbor maps with long-range interactions accounted for using the new transition charge model and an existing electrostatic map for long-range interaction frequency shifts. This model and others, which account for the frequency shifts by electrostatic maps exclusively, are tested by comparing the predicted IR spectra with those from DFT calculations on the pentapeptide [Leu]-enkephalin. The new model described above gives the best agreement and, after a systematic blueshift is accounted for, reproduces the DFT frequencies to within 3.5 cm(-1). The correlation of the intensities for this model with intensities from DFT calculations is 0.94.
Texture search engine (2011)

Texture image retrievals are gaining its popularity among the Computer Graphics committees in the World Wide Web (WWW). Many a times, graphic artists failed to retrieve their desire results as most texture image retrievals available are based on descriptive text. Exploiting on their artistic nature, user input is proposed in the paper to be based on sketch. Leveraging on Content Based Image Retrieval, we combined shape context techniques together with feature tracking techniques to search for similar patterns. Shape context is used as a primary contention to search for potential similar patterns while feature tracking technique is used for similarity measures to compute the ranking between texture images. The combined effort of both techniques yields a satisfactory result of 95% on a texture database filled with alphabetical patterns, with each texture image uniquely representing a letter.
A Fast Tree Pattern Matching Algorithm for XML Query (2005)

Finding all distinct matchings of the query tree pattern is the core operation of XML query evaluation. The existing methods for tree pattern matching are decomposition-matching-merging processes, which may produce large useless intermediate result or require repeated matching of some sub-patterns. We propose a fast tree pattern matching algorithm called TreeMatch to directly £nd all distinct matchings of a query tree pattern. The only requirement for the data source is that the matching elements of the non-leaf pattern nodes do not contain sub-elements with the same tag. The TreeMatch does not produce any intermediate results and the £nal results are compactly encoded in stacks, from which the explicit representation can be produced ef£ciently.
Facile hydrodehalogenation with hydrogen and palladium/carbon catalyst under multiphase conditions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile hydrodehalogenation with hydrogen and palladium/carbon catalyst under multiphase conditionsCarlos Alberto Marques, Maurizio Selva, and Pietro TundoCite this: J. Org. Chem. 1993, 58, 19, 5256–5260Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jo00071a041https://doi.org/10.1021/jo00071a041research-articleACS PublicationsRequest reuse permissionsArticle Views1011Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New mini-Tn<i>5</i> derivatives for insertion mutagenesis and genetic engineering in Gram-negative bacteria (1995)

Five mini-Tn5 derivatives encoding resistance to Km, Cm, Gm, Tc, and Sm, coupled with the polylinker of the pBluescriptII plasmid, were constructed. These derivatives are carried by an ampicillin-resistant plasmid that has a conditional origin of replication from plasmid R6K and origin of conjugal transfer from the broad host range plasmid RP4. The new vectors are smaller than those previously described and possess numerous unique restriction sites inside the minitransposons for gene cloning in addition to SfiI and NotI sites found in their predecessors.
On the scenario and heuristics of disassemblies (2002)

A general scenario of disassembly is figured out, starting from the authors' past study of the internal structures of machines and devices, based on a mechanical engineer's point of view. The authors argue that among all data relevant to assembly, the key data for generating assembly sequences are the liaison type and the assembly direction. From these data many important geometrical, topological and technological constraints can be inferred that can be used as criteria for reducing the user's input data and the information to be extracted from the CAD database. These criteria minimize the possible decompositions at each stage of disassembly, and may even guide the search towards the best plan. A fast planner has been implemented in PROLOG, giving a user friendly system capable of generating optimal assembly plans very quickly, with a computational cost roughly proportional to the number of parts in the final assembly.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>