gebhart/patrepeval huggingface dataset:
Anatomic barriers influence the distribution of in vivo gene transfer into the arterial wall. Modeling with microscopic tracer particles and verification with a recombinant adenoviral vector. (1994)

We evaluated the extent to which anatomic barriers to vector penetration might influence the distribution of successful in vivo gene transfer into the normal arterial wall. A double-balloon catheter technique with infusion pressures of 100 to 400 mm Hg was used to infuse microscopic tracer particles of the size range of liposomes and viral vectors into normal elastic arteries of sheep. Localization of the tracer particles in tissue sections by light, fluorescence, and electron microscopy suggested that vector-sized particles were delivered to the intima by direct infusion and to the adventitia via the arterial vasa vasorum. Particles were virtually absent from the arterial media. To test the predictions made from the particle studies, we repeated the infusion protocol with high-titer adenoviral vectors. Gene transfer occurred at high levels in the intima and along the adventitial vasa vasorum but again was virtually absent within the media. The ability of medial smooth muscle cells to be transduced was established in separate experiments with a high-pressure (5 atm) porous balloon infusion catheter. We conclude that (1) the anatomy of the normal elastic arterial wall imposes significant limitations on the penetration of particles in the size range of most gene-transfer vectors and (2) the distribution of in vivo gene transfer with adenoviral vectors is correctly predicted by the distribution of inert tracer particles. These findings have important implications for the design of arterial gene-transfer and gene-therapy protocols.
A Novel Cooperative Strategy for Wireless Multihop Backhaul Networks (2015)

The 5G wireless network architecture will bring dense deployments of base stations called {\em small cells} for both outdoors and indoors traffic. The feasibility of their dense deployments depends on the existence of a high data-rate transport network that can provide high-data backhaul from an aggregation node where data traffic originates and terminates, to every such small cell. Due to the limited range of radio signals in the high frequency bands, multihop wireless connection may need to be established between each access node and an aggregation node. In this paper, we present a novel transmission scheme for wireless multihop backhaul for 5G networks. The scheme consists of 1) {\em group successive relaying} that established a relay schedule to efficiently exploit half-duplex relays and 2) an optimized quantize-map-and-forward (QMF) coding scheme that improves the performance of QMF and reduces the decoding complexity and the delay. We derive an achievable rate region of the proposed scheme and attain a closed-form expression in the asymptotic case for several network models of interests. It is shown that the proposed scheme provides a significant gain over multihop routing (based on decode-and-forward), which is a solution currently proposed for wireless multihop backhaul network. Furthermore, the performance gap increases as a network becomes denser. For the proposed scheme, we then develop energy-efficient routing that determines {\em groups} of participating relays for every hop. To reflect the metric used in the routing algorithm, we refer to it as {\em interference-harnessing} routing. By turning interference into a useful signal, each relay requires a lower transmission power to achieve a desired performance compared to other routing schemes. Finally, we present a low-complexity successive decoder, which makes it feasible to use the proposed scheme in practice.
Monocular SLAM and Obstacle Removal for Indoor Navigation (2018)

Visual Simultaneous Localization and Mapping (SLAM) is one of the hot topics in computer vision. For the past few years, the AI and deep learning technology research have been widespread used in self-driving technology and surveillance system etc., gaining more and more attention from researchers and public media. The combination of AI technology and robot perception is inevitably going to be a trend. This paper aims at removing the obstacle to enhance the SLAM system performance that based on popular open source framework ORB-SLAM2 in dynamic environment. Moving objects will bring noise in camera pose estimation, besides, when in re-localization, the robot returns to the previous place finding the previous landmark mismatches because of its movement. The system will be confused and misdirected. A novel approach is proposed to remove the obstacle in real environment by using convolutional neural network (CNN) to generate a segmentation mask of obstacle object so as to eliminate the interference by moving object. Our experiment result shows an impressive outcome of practical use and benchmark dataset test.
p73 or p53 Directly Regulates Human <i>p53</i> Transcription to Maintain Cell Cycle Checkpoints (2006)

Whereas the p53 tumor suppressor protein plays a central role in cellular checkpoints that respond to damage or stress to prevent tumorigenesis, the transcriptional control of the p53 gene has remained unclear. We show that chemotherapeutic agents induce p53 transcription and that p73 or p53 transactivates endogenous p53 expression through direct binding to the p53 promoter. Silencing of p53 or p73 by RNA interference significantly suppresses p53 transcription under physiologic conditions or in response to cellular stress. Mutational analysis of the human p53 promoter localized a p53 DNA-binding site, which confers p53- or p73-dependent p53 promoter activation. Importantly, impaired p53-mediated autoregulation of p53 transcription by inducible-interfering RNA results in aberrant cell cycle regulation and suppression of p53-mediated apoptosis. Thus, a positive feedback loop regulates human p53 expression and involves p73 and p53. Disruption of p53 transcription contributes to defective checkpoint control.
Tumor response evaluation criteria for HCC (hepatocellular carcinoma) treated using TACE (transcatheter arterial chemoembolization): RECIST (response evaluation criteria in solid tumors) version 1.1 and mRECIST (modified RECIST): JIVROSG-0602 (2012)

Considerable differences in the CR rate and the response rate were observed. From the viewpoint of the high inter- and intra-observer reproducibility, mRECIST may be more suitable for tumor response criteria in clinical trials of TACE for HCC.
CDP-domain traveltime and waveform inversion for initial velocity estimation (2020)

To obtain a credible near-surface velocity model via full waveform inversion (FWI) requires an appropriate initial velocity model. Here, we present a two-step method to invert both travel time and waveform information in CDP gathers for 1D-velocity models. Specifically, the proposed approach takes each CDP gather as an input and output a 1D-velocity profile at the CDP center by performing Wave-equation Traveltime Inversion (WTI) and FWI consecutively. In addition, we also compute long-wavelength static correction from the inverted velocity profile since ray paths are often nearly vertical when approaching the earth surface. We verified the validation of the proposed WT-FWI method with two land data sets. Presentation Date: Wednesday, October 14, 2020 Session Start Time: 1:50 PM Presentation Time: 3:55 PM Location: 362C Presentation Type: Oral
Isolated Seven-Coordinate Ru(IV) Dimer Complex with [HOHOH]<sup>−</sup> Bridging Ligand as an Intermediate for Catalytic Water Oxidation (2009)

With the inspiration from an oxygen evolving complex (OEC) in Photosystem II (PSII), a mononuclear Ru(II) complex with a tetradentate ligand containing two carboxylate groups has been synthesized and structurally characterized. This Ru(II) complex showed efficient catalytic properties toward water oxidation by the chemical oxidant cerium(IV) ammonium nitrate. During the process of catalytic water oxidation, Ru(III) and Ru(IV) species have been successfully isolated as intermediates. To our surprise, X-ray crystallography together with HR-MS revealed that the Ru(IV) species is a seven-coordinate Ru(IV) dimer complex containing a [HOHOH](-) bridging ligand. This bridging ligand has a short O...O distance and is hydrogen bonded to two water molecules. The discovery of this very uncommon seven-coordinate Ru(IV) dimer together with a hydrogen bonding network may contribute to a deeper understanding of the mechanism for catalytic water oxidation. It will also provide new possibilities for the design of more efficient catalysts for water oxidation, which is the key step for solar energy conversion into hydrogen by light-driven water splitting, the ultimate challenge in artificial photosynthesis.
Using Parametric Modeling to Improve the Equipment Systems Coordination Process for Buildings (2010)

The coordination of equipment systems has become a major challenge for building contractors. Specialty design firms and trade contractors, working independently, provide these systems. For the past several years the equipment systems coordination has involved sequentially comparing and overlaying drawings from multiple trades, in which representatives from each equipment trade work together to detect, and eliminate spatial and functional interferences between equipment Systems. This multi-discipline effort is time-consuming and expensive. With the recent development of Building Parametric Modeling(BPM)this process is now able to evolve with the software technology. Using examples from several case studies, this paper demonstrates how BPM can improve the Equipment Systems coordination process in buildings. The results of this research provide a foundation for a revised work process utilizing modeling software and information technology.
Conformationally Restricted Analogs of 1α,25-Dihydroxyvitamin D<sub>3</sub> and Its 20-Epimer:  Compounds for Study of the Three-Dimensional Structure of Vitamin D Responsible for Binding to the Receptor (1996)

Two proteins play important roles in the expression of vitamin D function: the specific nuclear receptor protein (vitamin D receptor, VDR) and the transport protein (vitamin D binding protein, DBP). This study was conducted to clarify the conformation of vitamin D responsible for binding to those proteins. For the purpose, the side chain mobility of 1,25(OH)2D3 (1) and its 20-epimer, 20-epi-1,25(OH)2D3 (2), was analyzed by a systematic conformational search. The results were depicted as a three-dimensional dot map, which indicates that the side chains of the two vitamins (1 and 2) occupy different spatial regions that are separated in two areas. We denoted these areas as A and G for 1 and EA and EG for 2. Four analogs, the diastereomers at C(20) and C(22) (3-6) of 22-methylated 1,25(OH)2D3 whose side chains were confined to occupy G, A, EA, and EG, respectively, were designed. These analogs (3-6) were synthesized efficiently by a stereoselective conjugate addition of organocuprate to steroidal E- and Z-22-en-24-ones as the key step. In binding to the VDR the affinities of the analogs (3-6) relative to 1,25-(OH)2D3 (1) were 1/60, 1/3, 20, and 1/100, respectively. These results indicate that the A region is responsible for binding of 1 to VDR and the EA region for binding of 2. Only isomer 4 showed significant affinity for DBP, indicating only the A region is responsible for binding to DBP. Thus, 5 showed clear separation of binding affinities for two proteins, VDR and DBP. Having the highest known VDR affinity, (22R)-22-methyl-20-epi-1,25(OH)2D3 (5) has potential both as a therapeutic agent and as a tool to study the molecular mechanism of vitamin D-mediated gene transcription.
Lipoxygenase Inhibitors Enhance Body Fat Reduction in Mice by Conjugated Linoleic Acid and Inhibit Heparin-Releasable Lipoprotein Lipase Activity in 3T3-L1 Adipocytes (2001)

The t10c12 isomer of conjugated linoleic acid (CLA) reduces lipid accumulation in adipocytes in part by inhibiting heparin-releasable lipoprotein lipase (LPL) activity. We now show that inhibitors of lipoxygenase (LOX) activity (2-[12-hydroxydodeca-5,10-diynyl]-3,5,6-trimethyl-p-benzoquinone; 5,8,11,14-eicosatetraynoic acid; salicylhydroxamic acid; indomethacin; nordihydroguaiaretic acid (NDGA)) produce a similar inhibitory effect on LPL activity in cultured 3T3-L1 mouse adipocytes. Additionally the LOX inhibitors had no effect on, or inhibited, lipolysis in this cell system (measured as glycerol release). Growing mice fed diet containing 0.1% NDGA for 4 weeks displayed 21% reduction in body fat, which was similar to 23% reduction in body fat produced by feeding diet containing a suboptimal amount of CLA (0.1%) for 4 weeks. Feeding diet containing both 0.1% NDGA and 0.1% CLA resulted in 51% reduction in body fat which was accompanied by significant increases in whole body water and protein. Aspirin, an inhibitor of cyclooxygenase 1 and 2, had no effect on LPL activity in 3T3-L1 adipocytes, did not affect body composition when fed to growing mice, and failed to influence the effects of CLA on LPL activity in 3T3-L1 cells or body composition in mice. These findings appear to provide new perspectives and insights into the relationships between CLA, eicosanoids, the control of lipid accumulation in adipocytes, and effects of CLA on the immune system.
Regulation of PKR and IRF-1 during hepatitis C virus RNA replication (2002)

The virus-host interactions that influence hepatitis C virus (HCV) replication are largely unknown but are thought to involve those that disrupt components of the innate intracellular antiviral response. Here we examined cellular antiviral pathways that are triggered during HCV RNA replication. We report that (i) RNA replication of HCV subgenomic replicons stimulated double-stranded RNA (dsRNA) signaling pathways within cultured human hepatoma cells, and (ii) viral RNA replication efficiency corresponded with an ability to block a key cellular antiviral effector pathway that is triggered by dsRNA and includes IFN regulatory factor-1 (IRF-1) and protein kinase R (PKR). The block to dsRNA signaling was mapped to the viral nonstructural 5A (NS5A) protein, which colocalized with PKR and suppressed the dsRNA activation of PKR during HCV RNA replication. NS5A alone was sufficient to block both the activation of IRF-1 and the induction of an IRF-1-dependent cellular promoter by dsRNA. Mutations that clustered in or adjacent to the PKR-binding domain of NS5A relieved the blockade to this IRF-1 regulatory pathway, resulting in induction of IRF-1-dependent antiviral effector genes and the concomitant reduction in HCV RNA replication efficiency. Our results provide further evidence to support a role for PKR in dsRNA signaling processes that activate IRF-1 during virus infection and suggest that NS5A may influence HCV persistence by blocking IRF-1 activation and disrupting a host antiviral pathway that plays a role in suppressing virus replication.
Transparent conducting aluminum-doped zinc oxide thin films for organic light-emitting devices (2000)

Aluminum-doped zinc oxide (AZO) thin films (∼3000 Å) with low electrical resistivity and high optical transparency have been grown by pulsed-laser deposition on glass substrates without a postdeposition anneal. Films were deposited at substrate temperatures ranging from room temperature to 400 °C in O2 partial pressures ranging from 0.1 to 50 mTorr. For 3000-Å-thick AZO films grown at room temperature in an oxygen pressure of 5 mTorr, the electrical resistivity was 8.7×10−4 Ω cm and the average optical transmittance was 86% in the visible range (400–700 nm). For 3000-Å-thick AZO films deposited at 200 °C in 5 mTorr of oxygen, the resistivity was 3.8×10−4 Ω cm and the average optical transmittance in the visible range was 91%. AZO films grown at 200 °C were used as an anode contact for organic light-emitting diodes. The external quantum efficiency measured from these devices was about 0.3% at a current density of 100 A/m2.
The operating microscope. III. Accessories (1980)

The beam splitter, observation tubes, and assistant's microscope, available as accessories for the OPMI series of operating microscopes, are discussed.
Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. (1983)

A subline of the C57BL/6 mouse EL-4 thymoma produces upon stimulation with phorbol myristate acetate (PMA) a B cell growth factor (BCGF) that co-stimulates anti-IgM-stimulated splenic B cells. The BCGF present in the EL-4 thymoma culture supernatants is shown to be distinct from IL 2 by a variety of chromatographic criteria. Untreated BCGF exhibits a heterogeneity of isoelectric points (pH 6.4 to 6.6, 7.4 to 7.6, 8.5 to 8.7) all of which are more alkaline than that of IL 2 (pl 3.5 to 4.8). Neuraminidase-treated BCGF exhibits a single major pl of 9.3 that is also distinct from similarly treated IL 2. Moreover, IL 2 and BCGF exhibit distinct monomeric m.w. by SDS gel electrophoresis under nonreducing conditions (IL 2 is 21,000; BCGF is 11,000 and 15,000). The biologic activity of IL 2 is sensitive to trypsin inactivation as is BCGF activity. Thus, BCGF and IL 2 appear to be biologically and biochemically distinct glycoproteins.
Shear ordering in polymer photonic crystals (2010)

Optical scattering spectra are recorded in situ on flowing colloidal polymeric nanocomposites which are sheared into photonic crystals at 150 degrees C using a high-pressure quartz-cell multipass rheometer. Broadband spectroscopy of the resonant Bragg scattering peak allows the direct observation of crystal formation and melting of monodisperse core-shell particles. A range of flow conditions of this solventless, highly viscous melt reveals four distinct regimes of crystal growth and decay which match a simple rheological model. Extraction of crystal thickness, order and lattice spacing are validated by one-dimensional electromagnetic simulations.
A novel chemoradiation targeting stem and nonstem pancreatic cancer cells by repurposing disulfiram (2017)

Pancreatic ductal adenocarcinoma (PDAC) has a 5-year relative survival rate of 8% and is projected to be the second leading cause of cancer death by 2030, underscoring the urgency to develop new strategies to improve current therapeutic modalities for PDAC. Targeting pancreatic cancer stem cells (PCSCs), which are resistant to radiation and chemotherapy, is a promising strategy. A novel approach which can be readily clinically translated is to repurpose disulfiram (DSF), a drug for treating alcoholism, to target PCSCs. Chemoradiation or the combination of chemotherapy agents FOLFIRINOX, currently standard care for PDAC, can increase stemness in some established or primary PDAC cell lines. However, DSF in the presence of exogenously or endogenously supplied copper (Cu), when combined with chemotherapy or chemoradiation, targets both PCSCs and nonstem PDAC cells. Previously, we demonstrated that DSF/Cu effectively targets breast cancer stem cells in the context of fractionated radiation (FIR) by inhibiting the NF-κB-stemness gene pathway. Therefore, the hypothesis that PCSCs can be effectively targeted by incorporating DSF/Cu into the standard chemoradiation regimen consisting of 5-FU and FIR was investigated and found to be effective in vitro in targeting PCSCs, identified as either ALDH<sup>bright</sup> or CD24+/CD44+/ESA+ or sphere-forming cells, as well as nonstem PDAC cells. In vivo, the combination of IR+5-FU+DSF/Cu was more effective (72.46%) than either IR+5-FU (30.32%) or IR+FOLFIRINOX therapy (43.04%) in inhibiting growth of the mouse Panc02 tumor. These encouraging results provide a solid foundation for clinical trials to improve the outcomes of the current standard chemoradiation therapy regimen for PDAC.
RTED: A Robust Algorithm for the Tree Edit Distance (2011)

We consider the classical tree edit distance between ordered labeled trees, which is defined as the minimum-cost sequence of node edit operations that transform one tree into another. The state-of-the-art solutions for the tree edit distance are not satisfactory. The main competitors in the field either have optimal worst-case complexity, but the worst case happens frequently, or they are very efficient for some tree shapes, but degenerate for others. This leads to unpredictable and often infeasible runtimes. There is no obvious way to choose between the algorithms. In this paper we present RTED, a robust tree edit distance algorithm. The asymptotic complexity of RTED is smaller or equal to the complexity of the best competitors for any input instance, i.e., RTED is both efficient and worst-case optimal. We introduce the class of LRH (Left-Right-Heavy) algorithms, which includes RTED and the fastest tree edit distance algorithms presented in literature. We prove that RTED outperforms all previously proposed LRH algorithms in terms of runtime complexity. In our experiments on synthetic and real world data we empirically evaluate our solution and compare it to the state-of-the-art.
Biomechanics of Skin and Soft Tissue Trauma (2012)

This chapter contains sections titled: Structure of skin Mechanical properties of skin Effect of age Wounding Sharp force trauma Blunt force trauma Ballistic trauma Bitemarks
Scientific Reviews: Status and Future Development of Neutron Scintillation Detectors (2006)

In scintillation detectors for neutron scattering applications, the characteristics of the scintillator play a critical role in determining detector performance. There are two types of scintillator in common use; GS20:Ce glass scintillator and ZnS:Ag/6LiF scintillator [1 Spowart, A.R. 1969. Measurement of the absolute scintillation efficiency of granular and glass neutron scintillators. Nucl. Instr. and Meth., 75: 35–42. [Crossref] , [Google Scholar]]. GS20 glass produces ˜6000 photons per absorbed neutron, is generally transparent to its emitted light, and has a relatively fast decay time constant of 70 ns. Therefore detectors based on GS20 scintillator can readily be made with high neutron detection efficiency and good pulse pair resolution. However, neutron/gamma discrimination and intrinsic detector background can be problematic. ZnS:Ag/6LiF produces a far higher light yield, ˜150,000 photons per neutron, but is opaque to its emitted light, and whilst the primary decay time constant of 200 ns is moderately fast, afterglow can exist for 10s of microseconds.
High performance AlGaInP visible light-emitting diodes (1990)

The performance of surface-emitting visible AlGaInP light-emitting diodes (LEDs) is described. The devices have external quantum efficiencies greater than 2% and luminous efficiencies of 20 lm/A in the yellow (590 nm) spectral region. This performance is roughly ten times better than existing yellow LEDs and is comparable to the highest performance red AlGaAs LEDs currently available. The devices also perform favorably compared to existing devices in the orange and green spectral regions. Low-pressure organometallic vapor phase epitaxy (OMVPE) is used to grow the epitaxial layers. The devices consist of a double heterostructure with an AlGaInP active region grown on a GaAs substrate.