gebhart/patrepeval huggingface dataset:
Microporosity of BIF hosted massive hematite ore, Iron Quadrangle, Brazil (2002)

Massive hematite ore (MHO) is a special high-grade iron ore, used as lump ore in the process of obtaining direct reduction iron (DRI). The influence of porosity on the reducibility of MHO from the Capitão do Mato Mine (Iron Quadrangle, Brazil) was investigated using optical and scanning electron microscopes on drill core and open pit samples. Hematite is the main component of the samples and occurs as granular crystals (10 mum), microplates (1 mum) and euhedral martite (10 to 30 mum). Quartz, maghemite, kenomagnetite and goethite are minor components. Primary micropores (Å to 1 mum) are associated with microplaty crystals that fill cavities between granular hematite. Secondary micropores (Å to 5 mum) related to euhedral martite crystals, are the most important. The total porosity of weathered samples, measured using nitrogen adsorption and mercury injection, attains values up to 11%, whereas unweathered samples have a porosity less than 2.5%. Reducibility is strongly enhanced by porosity, but inhibited by structure (bedding).
Crystal structure of a recombinant α <sub>E</sub> C domain from human fibrinogen-420 (1998)

The crystal structure of a recombinant alphaEC domain from human fibrinogen-420 has been determined at a resolution of 2.1 A. The protein, which corresponds to the carboxyl domain of the alphaE chain, was expressed in and purified from Pichia pastoris cells. Felicitously, during crystallization an amino-terminal segment was removed, apparently by a contaminating protease, allowing the 201-residue remaining parent body to crystallize. An x-ray structure was determined by molecular replacement. The electron density was clearly defined, partly as a result of averaging made possible by there being eight molecules in the asymmetric unit related by noncrystallographic symmetry (P1 space group). Virtually all of an asparagine-linked sugar cluster is present. Comparison with structures of the beta- and gamma-chain carboxyl domains of human fibrinogen revealed that the binding cleft is essentially neutral and should not bind Gly-Pro-Arg or Gly-His-Arg peptides of the sort bound by those other domains. Nonetheless, the cleft is clearly evident, and the possibility of binding a carbohydrate ligand like sialic acid has been considered.
Determination of electroosmotic and electrophoretic mobility of DNA and dyes in low ionic strength solutions (2017)

Nanocoding, a genome analysis platform, relies on very low ionic strength conditions to elongate DNA molecules up to 1.06 (fully stretched DNA = 1). Understanding how electroosmotic and electrophoretic forces vary, as ionic strength decreases, will enable better Nanocoding devices, or other genome analysis platforms, to be developed. Using gel electrophoresis to determine overall mobility (includes contributions from electrophoretic and electroosmotic forces) in different ionic strength conditions, linear DNA molecules (pUC19 (2.7 kb), pBR322 (4.4 kb), ΦX174 (5.4 kb), and PSNAPf-H2B (6.2 kb)) were analyzed in varying gel concentrations (1.50, 1.25, 1.00, 0.75, and 0.50%). Additionally, buffer concentration (Tris-EDTA, TE) was varied to determine free solution mobility at different ionic strength solutions. As ionic strength decreased from 13.8 to 7.3 mM, overall mobility increased. As TE buffer decreased (< 7.3 mM), overall mobility drastically decreased as ionic strength decreased. Rhodamine B dye was utilized to determine the electroosmotic mobility. As the ionic strength decreased, electroosmotic mobility increased. The experimental electrophoretic mobility was compared to theoretical considerations for electrophoretic mobility (Pitts and Debye-Hückel-Onsager). Electroosmotic forces decreased the overall mobility of DNA molecules and bromophenol blue migration in a gel matrix as ionic strength decreased.
Labeling Tetracysteine‐Tagged Proteins with a SplAsH of Color: A Modular Approach to Bis‐Arsenical Fluorophores (2007)

Everything nicely tied up. We have synthesized a non-fluorescent bis-arsenical targeting moiety that can be tethered to a wide variety of different fluorescent payloads. This strategy greatly broadens the scope of dyes that can be used to label tetracysteine-tagged proteins.
Generation of Uniformly Sized, Charged Particles in a Vacuum (1991)

An experimental technique that uses a modified vibrating orifice aerosol generator has been developed for the continuous generation of monodisperse, charged particles in subatmospheric pressure. The technique achieves well-defined control of charge of either polarity by induction charging of the uniformly sized particles produced by the aerosol generator. Particle charge was measured by the collection of particles in a Faraday cup connected to a microammeter. The size and morphology of the particles generated by this device were investigated by using optical and scanning electron microscopy. The performance of the vibrating orifice aerosol generator with and without the use of the conventional syringe pump was investigated for vacuum operation. The technique is found to be a useful method to generate charged aerosol particles for the study of aerosol behavior in vacuum conditions.
The non-coding transcriptome as a dynamic regulator of cancer metastasis (2013)

Since the discovery of microRNAs, non-coding RNAs (NC-RNAs) have increasingly attracted the attention of cancer investigators. Two classes of NC-RNAs are emerging as putative metastasis-related genes: long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs). LncRNAs orchestrate metastatic progression through several mechanisms, including the interaction with epigenetic effectors, splicing control and generation of microRNA-like molecules. In contrast, snoRNAs have been long considered "housekeeping" genes with no relevant function in cancer. However, recent evidence challenges this assumption, indicating that some snoRNAs are deregulated in cancer cells and may play a specific role in metastasis. Interestingly, snoRNAs and lncRNAs share several mechanisms of action, and might synergize with protein-coding genes to generate a specific cellular phenotype. This evidence suggests that the current paradigm of metastatic progression is incomplete. We propose that NC-RNAs are organized in complex interactive networks which orchestrate cellular phenotypic plasticity. Since plasticity is critical for cancer cell metastasis, we suggest that a molecular interactome composed by both NC-RNAs and proteins orchestrates cancer metastasis. Interestingly, expression of lncRNAs and snoRNAs can be detected in biological fluids, making them potentially useful biomarkers. NC-RNA expression profiles in human neoplasms have been associated with patients' prognosis. SnoRNA and lncRNA silencing in pre-clinical models leads to cancer cell death and/or metastasis prevention, suggesting they can be investigated as novel therapeutic targets. Based on the literature to date, we critically discuss how the NC-RNA interactome can be explored and manipulated to generate more effective diagnostic, prognostic, and therapeutic strategies for metastatic neoplasms.
Interfacing Incompatible Protocols Using Interface Process Generation (1995)

During system design, one or more portions of the system may be implemented with standard components that have a fixed pin structure and communication protocol. This paper described a new technique, interface process generation, for interfacing standard components that have incompatible protocols. Given an HDL description of the two protocols, we present a method to generate an interface process that allows the two protocols to communicate with each other.
Multi-switch Satellite Digital System (MSDS) (2008)

In this paper we developed multi-switch satellite digital system (MSDS). MSDS provides eight output lines from three input lines. The MSDS system is suitable for airport hotels where many users can use different satellites (Hotbird, Nilesat, Cirius ... etc) using only single fixed dish with three low noise blocks (LNB), instead of using three fixed dishes with three LNBs. This system can be modified to be suitable for n number of users.
[Gliotoxic factor and multiple sclerosis]. (1996)

Multiple sclerosis in a disease of the central nervous system characterized by perivascular and periventricular lesions of the myelin and immune cell infiltrates and increased permeability of the blood-brain barrier. We have found a cytotoxic factor of the cerebrospinal fluid (CSF) specific for multiple sclerosis patients which has 2 main characteristic effects in vitro on primary or immortalized astrocyte cultures: (1) disruption of the gliofilament network of the cells; and (2) apoptotic cell death induction. Moreover, in vivo, intraventricular injections of minute amounts of partially purified gliotoxic factor in adult rats have striking effects on both the morphology and general organization of astrocytes in the entire brain and the permeability characteristics of the blood brain barrier, which becomes leaky to immunoglobulins. These pathological effects are strongly similar to some of the neuropathological findings reported during the course of MS--They suggest an entirely new hypothesis to explain the active stage of the disease: the presence of a new factor of unknown extrinsic (viral) or intrinsic (cellular) origin, able to disorganize the glial cytoskeleton and glial cell differentiation. This factor is then able to provoke glial cell death. Such glial cell death may result in both demyelination and increased blood brain barrier permeability. Both in vitro and in vivo studies strongly support the idea that this gliotoxic factor plays a central role in the pathogenesis of MS, making its full identification a critical theme for MS research.
The Lung Lesion in Four Different Types of Shock in Rabbits (1972)

Endotoxemia was demonstrated in over 90% (28 of 30) of a series of animals subjected to one of four different types of refractory shock. Microscopic study of the lungs showed that the changes characteristic of the lung lesion in shock did not occur unless an endotoxemia developed and persisted until death. When pretreatment by inducing resistance to endotoxin or by intraintestinal administration of nonabsorbable antibiotics prevented the endotoxemia or converted a persistent to a transient endotoxemia, there was a corresponding reduction in the incidence of the lung lesion and the mortality.
FTDP‐17 tau mutations decrease the susceptibility of tau to calpain I digestion (1999)

Frontal temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is caused by splice site and missense mutations in the tau gene, and characterized by the accumulation of filamentous tau in cerebral neurons and glia. The missense mutations reduce the ability of tau to promote microtubule assembly and increase the ability of tau to form filaments. In this report we demonstrate that mutants V337M and R406W are less susceptible than mutant P301L or corresponding wild type tau to degradation by calpain I. The differences were at least in part due to changes in accessibility of a cleavage site located about 100 amino acids off the carboxy-terminus. The results suggest that the pathogenesis of some forms of FTDP-17 may involve tau accumulation due to decreased proteolytic degradation.
Point spread function mapping with parallel imaging techniques and high acceleration factors: Fast, robust, and flexible method for echo‐planar imaging distortion correction (2004)

Echo-planar imaging (EPI) is an ultrafast magnetic resonance (MR) imaging technique prone to geometric distortions. Various correction techniques have been developed to remedy these distortions. Here improvements of the point spread function (PSF) mapping approach are presented, which enable reliable and fully automated distortion correction of echo-planar images at high field strengths. The novel method is fully compatible with EPI acquisitions using parallel imaging. The applicability of parallel imaging to further accelerate PSF acquisition is shown. The possibility of collecting PSF data sets with total acceleration factors higher than the number of coil elements is demonstrated. Additionally, a new approach to visualize and interpret distortions in the context of various imaging and reconstruction methods based on the PSF is proposed. The reliable performance of the PSF mapping technique is demonstrated on phantom and volunteer scans at field strengths of up to 4 T.
Implementation of large kernel 2-D convolution in limited FPGA resource (2007)

2-D Convolution is a simple mathematical operation which is fundamental to many common image processing operators. Using FPGA to implement the convolver can greatly reduce the DSP's heavy burden in signal processing. But with the limit resource the FPGA can implement a convolver with small 2-D kernel. In this paper, An FIFO type line delayer is presented to serve as the data buffer for convolution to reduce the data fetching operation. A finite state machine is applied to control the reuse of multipliers and adders arrays. With these two techniques, a resource limited FPGA can be used to implement a larger kernel convolver which is commonly used in image process systems.
Spectral volume rendering (2000)

Volume renderers for interactive analysis must be sufficiently versatile to render a broad range of volume images: unsegmented "raw" images as recorded by a 3D scanner, labeled segmented images, multimodality images, or any combination of these. The usual strategy is to assign to each voxel a three component RGB color and an opacity value /spl alpha/. This so-called RGB/spl alpha/ approach offers the possibility of distinguishing volume objects by color. However, these colors are connected to the objects themselves, thereby bypassing the idea that in reality the color of an object is also determined by the light source and light detectors c.q. human eyes. The physically realistic approach presented, models light interacting with the materials inside a voxel causing spectral changes in the light. The radiated spectrum falls upon a set of RGB detectors. The spectral approach is investigated to see whether it could enhance the visualization of volume data and interactive tools. For that purpose, a material is split into an absorbing part (the medium) and a scattering part (small particles). The medium is considered to be either achromatic or chromatic, while the particles are considered to scatter the light achromatically, elastically, or inelastically. Inelastic scattering particles combined with an achromatic absorbing medium offer additional visual features: objects are made visible through the surface structure of a surrounding volume object and volume and surface structures can be made visible at the same time. With one or two materials the method is faster than the RGB/spl alpha/ approach, with three materials the performance is equal. The spectral approach can be considered as an extension of the RGB/spl alpha/ approach with greater visual flexibility and a better balance between quality and speed.
EMG, single fibre EMG and sacral reflexes in assessment of sacral nervous system lesions. (1982)

EMG of pelvic floor muscles, single fibre EMG of external anal sphincter and both bulbocavernosus and anal reflexes were investigated in 31 men without sacral nervous system lesions and in 12 patients with neurogenic erectile impotence, of whom one had slight loss of sensitivity to pinprick in the lower sacral dermatomes. EMG and single fibre EMG abnormalities have been found concomitantly in eight patients and six of these had also prolonged bulbocavernosus reflex latencies. In two patients the prolonged bulbocavernosus reflex latency was the only abnormality. Single fibre EMG of anal sphincter muscle seems to be superfluous in routine evaluation of sacral nervous system lesions.
Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism (2003)

Proton nuclear magnetic resonance (NMR) spectroscopy of body fluids has been successfully applied to the field of inborn errors of metabolism. This technique has the advantage of minimal sample pretreatment not requiring extraction or derivatization steps. Moreover, the spectrum provides a comprehensive metabolic profile of proton-containing, low-molecular-weight metabolites. The sensitivity limit is in the low micromolar range. This allows diagnosis of many inborn errors of metabolism. This review explains the key features of the NMR spectrum and reviews the available literature on metabolic diseases. Three novel diseases have been delineated with the technique. Relevant parts of the spectra from the urine samples of patients with these diseases are shown. NMR spectroscopy may develop to become a key tool in a metabonomics approach in clinical biochemistry.
[Evaluation of commercial systems VITEK 2 and API 20NE for identification of Burkholderia cepacia complex bacteria from clinical samples]. (2012)

Species belonging to the Burkholderia cepacia complex (BCC) are capable of causing chronic respiratory tract infections in patients suffering from cystic fibrosis as well as in immunocompromised individuals. Most of these species are highly resistant to antibiotic therapy, generating the need for their rapid and accurate detection for the proper treatment and clinical management of these patients. In this work, the polymerase chain reaction (PCR) technique based on the amplification of the recA gene (PCR-recA) was applied for an accurate identification of bacteria belonging to the BCC. Sensitivity (S) and specificity (E) of two biochemically-based commercial automated systems, API 20NE and VITEK 2 (bioMérieux®), and of the most representative biochemical manual tests for the identification of the Burkholderia cepacia complex were herein evaluated. The commercial systems VITEK 2 and API 20NE showed the following sensitivity and specificity vaues for identification to the species level, S: 71.1 %, E: 100 %, S: 69.7 %, E: 90.2 %, respectively. More complex results were observed for phenotypic manual tests, since BCC bacteria can undergo selective pressure to survive in chronic patients causing the loss of their typical phenotypic characteristics. The PCR-recA technique was easy to implement even in medium-complexity clinical diagnostic laboratories.
Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives (2009)

A series of 44 4-aminopiperidine derivatives was screened in vitro against four protozoan parasites (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum). This screening identified 29 molecules selectively active against bloodstream-form T. b. rhodesiense trypomastigotes, with 50% inhibitory concentrations (IC50) ranging from 0.12 to 10 microM, and 33 compounds active against the chloroquine- and pyrimethamine-resistant K1 strain of P. falciparum (IC50 range, 0.17 to 5 microM). In addition, seven compounds displayed activity against intracellular T. cruzi amastigotes in the same range as the reference drug benznidazole (IC50, 1.97 microM) but were also cytotoxic to L-6 cells, showing little selectivity for T. cruzi. None of the molecules tested showed interesting antileishmanial activity against axenic amastigotes of L. donovani. To our knowledge, this is the first report of the antitrypanosomal activity of molecules bearing the 4-aminopiperidine skeleton.
Isolation of a Polyvalent Bacteriophage for <i>Escherichia coli, Klebsiella pneumoniae</i> , and <i>Aerobacter aerogenes</i> (1972)

A lytic bacteriophage isolated from sewage was found to attack strains of Aerobacter aerogenes, Escherichia coli, and Klebsiella pneumoniae, but not members of the genera Salmonella, Proteus, and Serratia. The phage, designated phimp, contained deoxyribonucleic acid with a 50% guanine plus cytosine ratio and a molecular weight of 23.1 x 10(6) daltons. Single-step growth experiments of phimp plated at 37 C on A. aerogenes A2 gave a mean latent period of 20 min, an average burst size of 103 plaque-forming units/infected cell, and an average adsorption rate constant of 3 x 10(-10) ml/min. Electron microscopy of phimp revealed a phage with a flexible tail (165 nm long and 6 nm wide). The phage head had a hexagonal outline (62 nm in diameter).
Scattering by a periodically apertured conducting screen (1961)

This paper presents a generalized variational method for calculation of equivalent-circuit parameters or scattering coefficients of any thin obstacle. The equivalent susceptance is obtained from an eigenvalue of a general-energy operator. The method is applied here to the scattering of a plane wave by a conducting screen containing a doubly-periodic array of square apertures. Previous variational formulations of analogous waveguide problems were largely restricted to cases in which only the dominant mode can propagate. In applying these methods to scattering problems, the ratio of aperture spacing to wavelength had to be restricted to less than unity at normal incidence so that no additional propagating modes were excited. The formulation presented here can be applied, however, for any number of propagating modes. Numerical results are presented for scattering by a periodically apertured screen, giving scattering coefficients as a function of wave number of the incident wave. The distribution of energy into higher-order diffraction lobes is evaluated.
Small Charged Rings. V. Expansion of the Aziridinium Ring by Reaction with Ketones<sup>1-4</sup> (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSmall Charged Rings. V. Expansion of the Aziridinium Ring by Reaction with Ketones1-4Nelson J. Leonard, Joseph V. Paukstelis, and Leonard E. BradyCite this: J. Org. Chem. 1964, 29, 11, 3383–3386Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/jo01034a062https://doi.org/10.1021/jo01034a062research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An analysis of the operational efficiency of major airports in the United States (2000)

Abstract Recently, considerable attention has been focused on the performance of various airlines and air carriers in terms of efficiency. Although it is obvious that air carriers use airports, few studies have focused on airport operational efficiency. This empirical study evaluates the operational efficiencies of 44 major U.S. airports using data envelopment analysis and some of its recent developments. Various airport characteristics are evaluated to determine their relationship to an airport's efficiency. Efficiency measures are based on four resource input measures including airport operational costs, number of airport employees, gates and runways, and five output measures including operational revenue, passenger flow, commercial and general aviation movement, and total cargo transportation. The results of this study have operational as well as public policy implications.