gebhart/patrepeval huggingface dataset:
Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin. (2000)

Anti-Fas monoclonal antibody (mAb) kills Fas-expressing cells by apoptosis. Several anticancer agents also mediate apoptosis and may share common intracellular pathways leading to apoptosis with Fas. Thus, we reasoned that combination treatment of drug-resistant cells with anti-Fas mAb and drugs might overcome their resistance. We investigated whether anticancer agents enhance Fas-mediated apoptosis and cytotoxicity against renal cell carcinoma (RCC) cells. Treatment of ACHN RCC cells with anti-Fas mAb in combination with 5-fluorouracil, vinblastine, IFN-alpha, or IFN-gamma did not overcome resistance to these agents. However, combination treatment with anti-Fas mAb and Adriamycin (ADR) resulted in a synergistic cytotoxic effect. Furthermore, synergy was also obtained even when the exposure time was shortened from 24 h to 8 or 2 h. Synergy was also achieved in four other RCC cell lines and five freshly derived human RCC cells. Treatment with anti-Fas mAb in combination with epirubicin or pirarubicin also resulted in a synergistic cytotoxic effect on ACHN cells. Similar results were achieved with a combination of humanized anti-Fas mAb and ADR. Incubation of ACHN cells with ADR augmented the expression of Fas and p53, but not Bcl-2, Bax, or caspase-3. However, the activity of caspase-3 itself was apparently enhanced after treatment with ADR alone or combined treatment with anti-Fas mAb. The synergy obtained in cytotoxicity with anti-Fas mAb and ADR was also achieved in apoptosis. Exposure of ACHN cells and freshly derived RCC cells to ADR enhanced their susceptibility to lysis by peripheral blood lymphocytes and tumor-infiltrating lymphocytes. This study demonstrates that combination treatment of RCC cells with anti-Fas mAb and ADR might overcome their resistance. The sensitization required a low concentration of ADR and a short exposure time, thus supporting the potential in vivo application of a combination of ADR and anti-Fas mAb or immunotherapy in the treatment of ADR- and/or immunotherapy-resistant RCC.
Axial-flux permanent-magnet air-cored generator for small-scale wind turbines (2005)

The design and development of an axial-flux permanent-magnet air-cored generator for use as a direct drive generator with small-scale wind and water turbines is described. The generator is designed for simplicity and ease of manufacture and consists of two rotor discs each with permanent magnets located around its periphery. The stator is made of plastic and has a number of bobbin-wound armature coils located around its periphery. A three-phase prototype generator has been designed and built with 16 magnets per rotor disc, 12 armature coils (four per phase) and an overall diameter of 495 mm. The generator produces 1000 W at 300 rpm or 2000 W at 500 rpm with an electrical efficiency substantially greater than 90%. The generator performs as predicted by the design process.
Pulse time-delay method for geophysical tomography (1988)

Geotomography methods are presented for reconstructions of index-of-refraction distributions for time-delay measurements. Two versions of the algebraic reconstruction technique (ART) are compared to the conjugate residual (CR) method with Lagrange multiplier conditioning. The CR method with Lagrange multiplier conditioning provided the best reconstructions for good anomaly boundary definition under noisy conditions. A ray bending model to account for refraction is also used in the reconstructions. Modifications are made in the algorithm to simplify its use and to improve the convergence stability. Two image filters, the two-group minimum-variance partition-average (MVP2-AVE) one and the selective smoothing (SS) one, are used in succession and some of the limitations of each filter are eliminated. This improves the implementation of the filters and the accuracy of the reconstructions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Advances in SPECT and PET (1988)

The major developments in SPECT (single-photon-emission computed tomography) and PET (positron-emission tomography) are reviewed, and the near-term objectives for further developments are discussed. SPECT tomographs consisting of rotating Anger cameras are improved through the use of fan-beam, cone-beam, and astigmatic collimators. At the same time dedicated SPECT tomographs using cylindrical stationary-detector geometry are being developed as an alternative. Whether they will find widespread use is considered to depend largely on the clinical utility of SPECT imaging and on the development of radiopharmaceuticals. PET tomographs continue to improve in spatial resolution, aided by the use of detector encoding schemes that reduce the number of photomultipliers relative to the number of scintillation crystals. This improved resolution must be combined with higher sensitivity in order to take full advantage of the improved resolution. High sensitivity can be achieved by using a large axial acceptance angle. It is noted that similarities between the two modalities are increasing both in detector development (especially for stationary systems) and reconstruction algorithms (particularly in true three-dimensional reconstructions), suggesting that an awareness of both fields will be needed to enhance the development of each one.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
New Radiopaque Bromine‐Containing Monomers for Dental Restorative Materials (2016)

Four bromine‐containing methacrylates 1 – 4 are synthesized from pentaerythritol tribromide and 2,2,2‐tribromoethanol and are characterized by 1 H and 13 C NMR spectroscopy. Their free radical polymerization is performed in dimethylformamide (DMF), using 2,2′‐azobis(2‐methylpropionitrile) as initiator. The photopolymerization behavior of monomers 1–4 is investigated using a differential scanning calorimeter. Homopolymerizations and copolymerizations with 2‐hydroxyethyl methacrylate are carried out. Both the presence of a carbamate group and of bromine atoms result in an increase of the polymerization rate. Dental resins are prepared by replacing a certain amount of 2‐(4‐cumyl‐phenoxy)ethyl methacrylate by monomers 3 and 4 in a model formulation. The incorporation of these methacrylates leads to a significant increase of the radiopacity. Resins based on mono­mer 4 exhibit improved mechanical properties. image
Optical absorption of twisted bilayer graphene with interlayer potential asymmetry (2014)

We investigate the band structure and the optical absorption spectrum of twisted bilayer graphenes with changing interlayer bias and Fermi energy simultaneously. We show that the interlayer bias lifts the degeneracy of the superlattice Dirac point, while the amount of the Dirac point shift is significantly suppressed in small rotation angles, and even becomes opposite to the applied bias. We calculate the optical absorption spectrum in various asymmetric potentials and Fermi energies, and associate the characteristic spectral features with the band structure. The spectroscopic features are highly sensitive to the interlayer bias and the Fermi energy, and widely tunable by the external field effect.
Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis) (2011)

Names influence how something is perceived. Diagnostic terms (diagnoses) are the names of diseases that are usually derived either from some distinctive characteristic of the disease or include an eponym recognizing someone who elucidated the disease. No matter how logical and appropriate a name may be, if it is not usable and used it is of no lasting value. This brief commentary focuses on the nomenclature of systemic vasculitides, and uses as a prime example Wegener's granulomatosis, which has been renamed recently 'granulomatosis with polyangiitis', in part because of concerns about the suitability of Friedrich Wegener as the source of an eponym. The most distinctive pathological feature of Wegener's granulomatosis is multi-focal necrotizing inflammation that has long been called granulomatosis. The systemic variant of Wegener's granulomatosis also is characterized by inflammation in many different vessels or different types, i.e. polyangiitis. Thus, granulomatosis with polyangiitis is a very appropriate alternative term for Wegener's granulomatosis. This term also is in accord with the name for a closely related vasculitis, i.e. microscopic polyangiitis. Terms that indicate aetiology and pathogenesis, when known, are useful to include in names for diseases (diagnoses). Anti-neutrophil cytoplasmic autoantibodies specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA) are implicated in the cause of granulomatosis with polyangiitis and thus also should be specified in the diagnosis (e.g. PR3-ANCA-positive granulomatosis with polyangiitis or MPO-ANCA-positive microscopic polyangiitis). As our understanding of the clinical manifestations, pathogenesis and aetiology of vasculitides change over time, the names and approaches for diagnosing these diseases will change accordingly.
Quasi-Cyclic LDPC Codes based on Pre-Lifted Protographs (2014)

Quasi-cyclic low-density parity-check (QC-LDPC) codes based on protographs are of great interest to code designers because analysis and implementation are facilitated by the protograph structure and the use of circulant permutation matrices for protograph lifting. However, these restrictions impose undesirable fixed upper limits on important code parameters, such as minimum distance and girth. In this paper, we consider an approach to constructing QC-LDPC codes that uses a two-step lifting procedure based on a protograph, and, by following this method instead of the usual one-step procedure, we obtain improved minimum distance and girth properties. We also present two new design rules for constructing good QC-LDPC codes using this two-step lifting procedure, and in each case we obtain a significant increase in minimum distance and achieve a certain guaranteed girth compared to one-step circulant-based liftings. The expected performance improvement is verified by simulation results.
Laser-Induced Breakdown Spectroscopy (LIBS), Part II: Review of Instrumental and Methodological Approaches to Material Analysis and Applications to Different Fields (2012)

The first part of this two-part review focused on the fundamental and diagnostics aspects of laser-induced plasmas, only touching briefly upon concepts such as sensitivity and detection limits and largely omitting any discussion of the vast panorama of the practical applications of the technique. Clearly a true LIBS community has emerged, which promises to quicken the pace of LIBS developments, applications, and implementations. With this second part, a more applied flavor is taken, and its intended goal is summarizing the current state-of-the-art of analytical LIBS, providing a contemporary snapshot of LIBS applications, and highlighting new directions in laser-induced breakdown spectroscopy, such as novel approaches, instrumental developments, and advanced use of chemometric tools. More specifically, we discuss instrumental and analytical approaches (e.g., double- and multi-pulse LIBS to improve the sensitivity), calibration-free approaches, hyphenated approaches in which techniques such as Raman and fluorescence are coupled with LIBS to increase sensitivity and information power, resonantly enhanced LIBS approaches, signal processing and optimization (e.g., signal-to-noise analysis), and finally applications. An attempt is made to provide an updated view of the role played by LIBS in the various fields, with emphasis on applications considered to be unique. We finally try to assess where LIBS is going as an analytical field, where in our opinion it should go, and what should still be done for consolidating the technique as a mature method of chemical analysis.
Harmonization of Global Land-Use Change and Management for the Period 850–2100 (LUH2) for CMIP6 (2020)

Abstract. Human land-use activities have resulted in large changes to the biogeochemical and biophysical properties of the Earth surface, with consequences for climate and other ecosystem services. In the future, land-use activities are likely to expand and/or intensify further to meet growing demands for food, fiber, and energy. As part of the World Climate Research Program Coupled Model Intercomparison Project (CMIP6), the international community is developing the next generation of advanced Earth System Models (ESMs) to estimate the combined effects of human activities (e.g. land use and fossil fuel emissions) on the carbon-climate system. A new set of historical data based on the History of the Global Environment database (HYDE), and multiple alternative scenarios of the future (2015–2100) from Integrated Assessment Model (IAM) teams, are required as input for these models. Here we present results from the Land-use Harmonization 2 (LUH2) project, with the goal to smoothly connect updated historical reconstructions of land-use with new future projections in the format required for ESMs. The harmonization strategy estimates the fractional land-use patterns, underlying land-use transitions, key agricultural management information, and resulting secondary lands annually, while minimizing the differences between the end of the historical reconstruction and IAM initial conditions and preserving changes depicted by the IAMs in the future. The new approach builds off a similar effort from CMIP5, and is now provided at higher resolution (0.25 × 0.25 degree), over a longer time domain (850–2100, with extensions to 2300), with more detail (including multiple crop and pasture types and associated management practices), using more input datasets (including Landsat remote sensing data), updated algorithms (wood harvest and shifting cultivation), and is assessed via a new diagnostic package. The new LUH2 products contain > 50 times the information content of the datasets used in CMIP5, and are designed to enable new and improved estimates of the combined effects of land-use on the global carbon-climate system.
Syntheses of 2-Hydroxymethylnicotinic Acid Lactone, 2-Hydroxymethylpyridine-3-acetic Acid Lactone, and Some of their Derivatives (1960)

New type 2, 3-disubstituted pyridine lactones were prepared from 2-methylnicotinic acid. The lactones, 2-hydroxymethylnicotinic acid lactone and 2-hydroxymethylpyridine-3-acetic acid lactone, were reacted with various amines to form the corresponding lactams, and the lactams were reduced with lithium aluminium hydride, yielding pyrrolopyridine and 1, 7-naphthyridine derivatives which possessed a fair degree of hypotensive action.
Budesonide: a new corticosteroid in bronchial asthma. (1980)

The time course of response to budesonide in a dose of 1000 microgram administered by inhalation, 800 microgram given by the oral route, and 40 microgram prednisolone administered orally, has been investigated in 12 patients suffering from chronic bronchial asthma. Budesonide is an epimeric mixture of a non-halogenated glucocorticoid, 16 alpha, 17 alpha-(22R,S)-propylmethylenedioxypregna-1,4-diene-11 beta, 21-diol-3,20-dione. Inhaled budesonide and prednisolone produced a statistically significant increase in PEF 2 h after being administered. The peak effect appeared to occur between 6 and 7 h after budesonide inhalation and about 9 h following prednisolone. When given orally, budesonide failed to produce any substantial changes in PEF.
Study on the Reversible Electrode Reaction of Na<sub>1–<i>x</i></sub>Ni<sub>0.5</sub>Mn<sub>0.5</sub>O<sub>2</sub> for a Rechargeable Sodium-Ion Battery (2012)

Layered NaNi(0.5)Mn(0.5)O(2) (space group: R ̅3m), having an O3-type (α-NaFeO(2) type) structure according to the Delmas' notation, is prepared by a solid-state method. The electrochemical reactivity of NaNi(0.5)Mn(0.5)O(2) is examined in an aprotic sodium cell at room temperature. The NaNi(0.5)Mn(0.5)O(2) electrodes can deliver ca. 105-125 mAh g(-1) at rates of 240-4.8 mA g(-1) in the voltage range of 2.2-3.8 V and show 75% of the initial reversible capacity after 50 charge/discharge cycling tests. In the voltage range of 2.2-4.5 V, a higher reversible capacity of 185 mAh g(-1) is achieved; however, its reversibility is insufficient because of the significant expansion of interslab space by charging to 4.5 V versus sodium. The reversbility is improved by adding fluoroethylene carbonate into the electrolyte solution. The structural transition mechanism of Na(1-x)Ni(0.5)Mn(0.5)O(2) is also examined by an ex situ X-ray diffraction method combined with X-ray absorption spectroscopy (XAS). The staking sequence of the [Ni(0.5)Mn(0.5)]O(2) slabs changes progressively as sodium ions are extracted from the crystal lattice. It is observed that the original O3 phase transforms into the O'3, P3, P'3, and P3" phases during sodium extraction. XAS measurement proves that NaNi(0.5)Mn(0.5)O(2) consists of divalent nickel and tetravalent manganese ions. As sodium ions are extracted from the oxide to form Na(1-x)Ni(0.5)Mn(0.5)O(2), nickel ions are oxidized to the trivalent state, while the manganese ions are electrochemically inactive as the tetravalent state.
Innovative Laser-Aided Manufacturing of Patterned Stamping and Cutting Dies: Processing Parameters (1998)

Abstract We have systematically investigated the process parameters of laser cladding CPM 10V on AISI 1045 steel substrates. Based on experimental results, we have made reasonable approximations and assumptions, developed a simple but realistic process model, relating the maximum clad thickness and various process parameters, for on-line production. The predicted results of this model are in good agreement with the experimental results. A 2.5 kW continuous-wave: CO 2 laser, a coaxial powder feeding system, and a CAD/CAM system were used for laser cladding experiments. The microstructure of cladding layer, interface and heat-affected zone are characterized by using optical microscopy. Microhardness measurements of laser cladding samples under different treatment conditions are also carried out.
Adaptive Federated Learning in Resource Constrained Edge Computing Systems (2018)

Emerging technologies and applications including Internet of Things (IoT), social networking, and crowd-sourcing generate large amounts of data at the network edge. Machine learning models are often built from the collected data, to enable the detection, classification, and prediction of future events. Due to bandwidth, storage, and privacy concerns, it is often impractical to send all the data to a centralized location. In this paper, we consider the problem of learning model parameters from data distributed across multiple edge nodes, without sending raw data to a centralized place. Our focus is on a generic class of machine learning models that are trained using gradient-descent based approaches. We analyze the convergence bound of distributed gradient descent from a theoretical point of view, based on which we propose a control algorithm that determines the best trade-off between local update and global parameter aggregation to minimize the loss function under a given resource budget. The performance of the proposed algorithm is evaluated via extensive experiments with real datasets, both on a networked prototype system and in a larger-scale simulated environment. The experimentation results show that our proposed approach performs near to the optimum with various machine learning models and different data distributions.
Optimization of a synchrotron based x-ray lithographic system (1989)

Exposure time and mask contrast are two of the main parameters affecting the x-ray lithographic (XRL) process. In a synchrotron-based XRL system (SXRL), both parameters strongly depend on the source spectrum and beamline characteristics. Calculations have been done in order to optimize a SXRL system (source+beamline), taking also into account another important parameter like resolution. One of the main results is that a ‘‘cutoff’’ mirror, generally used in many beamlines, strongly increases exposure times without significantly improving contrast and resolution.
Inferring who-is-who in the Twitter social network (2012)

In this paper, we design and evaluate a novel who-is-who service for inferring attributes that characterize individual Twitter users. Our methodology exploits the Lists feature, which allows a user to group other users who tend to tweet on a topic that is of interest to her, and follow their collective tweets. Our key insight is that the List meta-data (names and descriptions) provides valuable semantic cues about who the users included in the Lists are, including their topics of expertise and how they are perceived by the public. Thus, we can infer a user's expertise by analyzing the meta-data of crowdsourced Lists that contain the user. We show that our methodology can accurately and comprehensively infer attributes of millions of Twitter users, including a vast majority of Twitter's influential users (based on ranking metrics like number of followers). Our work provides a foundation for building better search and recommendation services on Twitter.
The Fall of One, the Rise of Many: A Survey on Multi-Biometric Fusion Methods (2017)

Increasing operational and security demands changed biometrics by shifting the focus from single to multi-biometrics. Multi-biometrics are mandatory in the current context of large international biometric databases and to accommodate new emerging security demands. Our paper is a comprehensive survey on multi-biometrics, covering two important topics related to the multi-biometric field: fusion methods and security. Fusion is a core requirement in multi-biometric systems, being the method used to combine multiple biometric methods into a single system. The fusion section surveys recent multi-biometric schemes categorized from the perspective of fusion method. The security section is a comprehensive review of current issues, such as sensor spoofing, template security, and biometric encryption. New research trends and open challenges are discussed, such as soft, adaptive contextual-based biometrics. Finally, an implementation blueprint for a multi-biometric system is presented in the form of a list of questions to be answered when designing the system.
A Gene Cluster Encoding Rhizoxin Biosynthesis in “ <i>Burkholderia rhizoxina</i> ”, the Bacterial Endosymbiont of the Fungus <i>Rhizopus microsporus</i> (2006)

Cloning, sequencing and gene analysis of the rhi gene locus in the genome of the rhizoxin-producing bacterial endosymbiont “Burkholderia rhizoxina” of the rice-pathogenic fungus Rhizopus microsporus provides the first insight into the giant trans-AT NRPS–PKS thiotemplate assembly line for the potent antimitotic macrolide.
Fractional Delay Filters Based on Generalized Cardinal Exponential Splines (2009)

Fractional delay filters (FDFs) play an important role in certain areas of digital signal processing and communication engineering, where it is desirable to generate delays that are of the order of a fraction of the sampling period. In this paper, we advocate the use of generalized cardinal exponential splines-a class of compactly supported functions that is much richer than the existing B-spline family-for designing precision FDFs. One advantage of using generalized cardinal exponential splines is that it provides ready access to several spline families and other kernels which could be used for FDF design. The B-spline and Lagrange interpolator based FDFs are a special case of our proposition. We also discuss a design example and show that it is possible to design filters that have lower interpolation errors as compared to its B-spline counterparts.
Transcriptome patterns in hidradenitis suppurativa: support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis (2019)

Evaluation of transcriptome patterns in HS compared with normal skin demonstrated downregulation of the antimicrobial peptide Dermcidin and the innate immune regulator IL-37, as well as upregulation of interferon pathways and pathways of leucocyte activation.