gebhart/patrepeval huggingface dataset:
EFFECT OF A SINGLE BOLUS OF ETOMIDATE UPON EIGHT MAJOR CORTICOSTEROID HORMONES AND PLASMA ACTH (1985)

In a prospective controlled trial we investigated the effect of an induction dose of etomidate (0.26 mg/kg i.v.) on plasma ACTH, progesterone, 17 alpha OH-progesterone, 11-deoxycortisol, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, and aldosterone in seven males undergoing general anaesthesia. Seven other male patients receiving thiopentone at induction (5.0 mg/kg i.v.) served as controls. Plasma ACTH concentrations rose higher in the etomidate group (346 +/- 124 vs. 117 +/- 74 pg/ml, mean +/- SEM), but the difference was not significant. After etomidate we found a clear suppression of plasma cortisol (P less than 0.01), cortisone (P less than 0.01), corticosterone (P less than 0.01), and aldosterone (P less than 0.05) compared to corticosteroid levels after induction with thiopentone. Plasma 11-deoxycortisol and 11-deoxycorticosterone concentrations were grossly elevated 210 min after etomidate (91 +/- 28 nmol/l and 7.04 +/- 0.47 nmol/l, respectively, P less than 0.01) demonstrating inhibition of 11 beta-hydroxylation of both glucocorticoid and mineralocorticoid intermediates. In contrast, no significant difference in plasma progesterone and 17 alpha-OH-progesterone levels was found between the two groups indicating that the cholesterol-side-chain cleavage enzyme is less sensitive to etomidate than 11 beta-hydroxylase. Our results suggest that after induction of anaesthesia with a single bolus of etomidate, inhibition of other enzymes in the corticosteroid-synthetic pathway (e.g. cholesterol-side-chain cleavage enzyme) is of little clinical relevance.
Rhizomes for Understanding the Production of Social Science (2005)

This article is about the social processes which produce social science knowledge. It is based on a discourse analysis of DELOS, a European research project into organizational learning in clusters of SMEs (Small to Medium Enterprises). The substantive focus is on the researchers' core theoretical object: the “cluster of SMEs.” This construct remained a highly contested artifact which, for complex reasons, defied singular definition. The analysis draws on, among others, the labyrinthine novels of Franz Kafka and the theoretical musings of Deleuze and Guattari on rhizomic forms of organization in connection with actor-network theory. It is argued that the intrinsic ambiguity and endless processes of social construction and reconstruction which characterized DELOS can be accounted for by seeing the production of social science as a continuous (and continuing) process that drifts along multiple organizational logics, theoretical perspectives, and local agendas. The article demonstrates how the reality of social scientific knowledge is something which the many actors endeavor to stabilize and re-stabilize as it circulates within a tirelessly working net-work.
Discrete bandelets with geometric orthogonal filters (2005)

This paper describes the construction of second generation bandelet orthogonal bases. The decomposition on a bandelet basis is computed using a wavelet filter bank followed by adaptive geometric orthogonal filters, that require O(N) operations. The resulting geometry is multiscale and calculated with a fast procedure that minimizes a Lagrangian cost at each scale. Image compression with the resulting bandelet transform code gives significantly better results than a wavelet transform code.
LTE performance study (2012)

Long Term Evolution (LTE) has been designed with new architecture and features to meet user’s high data rates demand for a longer term in the future. 3rd Generation Part-nership Project (3GPP) has set the goals and targets for LTE with better performance and data rates close to fixed networks. \n\nIn this thesis outdoor measurements have been conducted in three different environ-ments macro/rural, urban and suburban. This thesis study has been done with single user measurements and performance analysis scenario. The idea of measurements was to analyze LTE performance in three different types of environments. Performance analysis has been done using few key performance indicators and parameters including RSRP, RS SNR, MAC downlink throughput, timing advance and CQI. Vendor/operator specific key performance indicators and parameters were unknown.\n\nThe results and analysis of this thesis give an idea about LTE performance in three dif-ferent outdoor environments. The output of this thesis study can be beneficial in under-standing LTE behavior and performance in different environments, which can be further useful in planning and deployment phases for LTE.
Adenovirus isolation from spleen lymphocytes of apparently healthy pigs. (1997)

A polyethylene glycol treatment was given to fuse KSEK6 cells, an established cell line derived from porcine embryo kidney, with the lymphocytes, separated from spleens of 35 apparently healthy slaughtered pigs. Eight cytopathic virus strains were isolated from the lymphocytes of these pigs. Two virus strains were isolated by inoculating the spleen tissue homogenates to KSEK6 monolayer cultures. All of viruses were identified as porcine adenoviruses according to their physicochemical, serological and immunological properties. One of these virus strains was serologically proved to be independent from six serotypes of porcine adenoviruses ever known. The electrophoretic property of viral DNA of this strain was indicated to be different from those of other reference porcine adenoviruses. This means the presence of a 7th serotype in porcine adenoviruses.
Wavelength-Shift-Free Spectral Inversion Utilizing Optical Parametric Loop Mirror (1995)

Spectral inversion based on four-wave mixing (FWM) is one of the promising techniques to compensate for the temporal and spectral distortion of the optical signals caused by chromatic dispersion and optical nonlinearities in optical fiber communications1–3. In previous reports employing waveguide FWM devices2,3, wavelength-shift of the spectrally-inverted FWM wave from the input signal wave was considered to be inevitable3 in order to separate the FWM wave from the input waves with optical filtering. Recently, we proposed a novel FWM configuration that separates the generated FWM wave from the input signal and pump waves without optical filtering4,5. In this report, we present spectral inversion without wavelength shift using non-degenerate pump waves in the proposed configuration named the optical PArametric Loop Mirror (PALM).
Remarkable Addition Effect of In and Ga in the NO-CO Reaction over Pd/SiO2 (1998)

Abstract Addition of In or Ga to Pd/SiO2 accelerated the rate of NO-CO reaction dramatically, and N2O and CO2 were formed steadily even at room temperature. XRD measurements revealed that a Pd-In intermetallic compound plays an important role. The ensemble effect of In atoms weakened the adsorption of CO and NO, which may open a new reaction route for N2O formation.
Performance and Application of Titanium Alloys in Geothermal Brine Service (1984)

Abstract Documented field corrosion performance of various titanium alloy materials exposed to geothermal wellhead brines and separated fluids is reviewed. Extensive laboratory testing in hot synthetic geothermal and natural brine media confirms titanium’s overall excellent suitability for geothermal brine service with respect to general, pitting, crevice, and stress corrosion. Recommendations and guidelines for successful, cost-effective applications, involving direct geothermal brine contact, are presented with emphasis on proper titanium alloy selection.
Adaptive extraction of highlights from a sport video based on excitement modeling (2005)

This paper addresses the challenge of automatically extracting the highlights from sports TV broadcasts. In particular, we are interested in finding a generic method of highlights extraction, which does not require the development of models for the events that are thought to be interpreted by the users as highlights. Instead, we search for highlights in those video segments that are expected to excite the users most. It is namely realistic to assume that a highlighting event induces a steady increase in a user's excitement, as compared to other, less interesting events. We mimic the expected variations in a user's excitement by observing the temporal behavior of selected audiovisual low-level features and the editing scheme of a video. Relations between this noncontent information and the evoked excitement are drawn partly from psychophysiological research and partly from analyzing the live-video directing practice. The expected variations in a user's excitement are represented by the excitement time curve, which is, subsequently, filtered in an adaptive way to extract the highlights in the prespecified total length and in view of the preferences regarding the highlights strength: extraction can namely be performed with variable sensitivity to capture few "strong" highlights or more "less strong" ones. We evaluate and discuss the performance of our method on the case study of soccer TV broadcasts.
Sonography of the skin and subcutaneous tissues. (1993)

Recent developments in US instrumentation, in particular the advent of 20-MHz transducers, have made B-mode US imaging of the skin feasible. Various pathologic conditions of the skin, mainly tumors and inflammatory diseases, can now be visualized, measured and monitored. The widely available 7.5- and 10-MHz transducers are adequate for the examination of subcutaneous tissues. The knowledge of the normal anatomy of skin and subcutaneous tissues helps diagnose such pathologic conditions as epidermoid and sebaceous cysts, benign and malignant tumors (nevi, hemangiomas, dermatofibromas, melanomas, lipomas, angiomas and angiosarcomas), inflammatory processes (inflammatory dermatoses, panniculites), traumas and foreign bodies. US was also used to measure subcutaneous fat thickness, especially in malnutrition, diabetes mellitus and acromegaly or in the patients treated with pentoine. Finally, US was employed to guide the needle into the veins of the patients with diffuse edema. Thanks to its excellent spatial resolution and cost-effectiveness, high-resolution US is expected to be used more extensively in the evaluation of skin and subcutaneous tissues.
Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Coronary Arteries (2001)

The results indicate important physiological roles for COX-2-derived prostacyclin and raise concerns regarding an increased risk of acute vascular events in patients receiving COX-2 inhibitors. The risk may be increased in individuals with underlying inflammatory disorders, including coronary artery disease.
The Scientific Adventure (1952)

Mr. N. Clarke's otherwise very generous review of my book, The Scientific Adventure, in the Institute of Physics Bulletin for June, so completely misrepresents my attitude on the ethical problem that I must beg permission to try to remove the misunderstanding. Mr. Clarke states that my treatment of the subject is "capricious." It is true that the word "caprice" occurs once in the chapter in question, but in a context which gives what I am saying a very different significance from that implied by Mr. Clarke's words.
A High Resolution Cmos Imager With Active Pixel Using Capacitively Coupled Bipolar Operation (2005)

The active pixel sensor technology promises high performance than conventional CCD imagers.This paper reports a new high resolution CMOS imager with one transistor active pixel sensing based on capacitorcoupled bipolar action.The base capacitor is pulsed negatively for image integration and positively for image sensing.The pixel size is 5.9um x 5.9um (on 0.8um design rule).The prototype imager has an array of 480 x 640 and operating at 5v Vcc.This active pixel structure is promising for future highperformance and high-density imagers in the information highway era.
THE INHIBITORY EFFECT OF RETINOIC ACID ON THE PROLIFERATION AND THE ACTIVITY OF THE 6S DNA POLYMERASE FROM THE MYELOMA CELLS OF BLAB/C MICE (1994)

Mydoma cells from BALB/C mice were cultured with retinoic acid at.an end-concentration of 33.3μmol/L and with cytarabine at an end-concentration of 6.7μmol/L for 72 hours,the inhibitory rates of cell proliferation were 45.3%and 61.4%,respectively. The activity of the pure 6s DNA polymerase from myeloma cells nuclear of BALB/C mice was determined by the method of(3H)dTTP incorporation,retinoic acid at an end-concentration of 2,4,6,8 and 10μ mol/L inhibited the activity of 6s DNA polymerase in vitro with the inhibitory rates of 12.4%。18%,15.6%,30.7% nd 31.6%,respectively(P0.05～0.001,except the dose uf 2μ mol/L),the inhibitory rate of Positive control cytarabine at an end-concentration of 6μ mol/L was 49%(P0.001)The mechan hanism of antitumor action of retinoic acid was discussed.
Protection by NMDA Antagonists against Selective Cell Loss following Transient Ischaemia (1990)

We have administered antagonists acting competitively or noncompetitively at the N-methyl-D-aspartate receptor after a short period of incomplete ischaemia and evaluated selective neuronal loss in the CA1 region of the rat hippocampus. The competitive antagonists D-(-)-2-amino-7-phosphonoheptanoate (2APH); 100 or 330 mg/kg; 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP); 3.3 or 10 mg/kg; and CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylate) 3.3 or 10 mg/kg; and the noncompetitive antagonists MK801 [+)5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate), 0.3, 1, or 3 mg/kg, and dextrorphan, 2, 6, 18, or 54 mg/kg, were administered intraperitoneally 15 min and 5 h after a 10-min incomplete ischaemia period; additionally MK801 (1 or 3 mg/kg) and CGS 19755 (10 or 30 mg/kg) were administered 5 and 10 h postischaemia. Seven days after ischaemia, the brains were fixed by perfusion. CA1 pyramidal cell counts were performed on Nissl-stained sections using an ocular grid piece. Ventilated (no ischaemia) control animals had a mean of 406 +/- 13 CA1 neurones/3 grid lengths. Ischaemia reduced this mean to 157 +/- 23. A significant protective effect against this cell loss was seen after two injections (at 15 min and 5 h postischaemia) of 2APH, CPP (10 mg/kg), CGS 19755 (10 mg/kg), MK801 (1 mg/kg), and dextrophan (54 mg/kg). Delayed injection (5 and 10 h postischaemia) of CGS 19755 (10 and 30 mg/kg) and MK801 (1 and 3 mg/kg) did not provide any protection against pyramidal cell loss.
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells (2013)

Efficient generation of competent vasculogenic cells is a critical challenge of human induced pluripotent stem (hiPS) cell-based regenerative medicine. Biologically relevant systems to assess functionality of the engineered vessels in vivo are equally important for such development. Here, we report a unique approach for the derivation of endothelial precursor cells from hiPS cells using a triple combination of selection markers--CD34, neuropilin 1, and human kinase insert domain-containing receptor--and an efficient 2D culture system for hiPS cell-derived endothelial precursor cell expansion. With these methods, we successfully generated endothelial cells (ECs) from hiPS cells obtained from healthy donors and formed stable functional blood vessels in vivo, lasting for 280 d in mice. In addition, we developed an approach to generate mesenchymal precursor cells (MPCs) from hiPS cells in parallel. Moreover, we successfully generated functional blood vessels in vivo using these ECs and MPCs derived from the same hiPS cell line. These data provide proof of the principle that autologous hiPS cell-derived vascular precursors can be used for in vivo applications, once safety and immunological issues of hiPS-based cellular therapy have been resolved. Additionally, the durability of hiPS-derived blood vessels in vivo demonstrates a potential translation of this approach in long-term vascularization for tissue engineering and treatment of vascular diseases. Of note, we have also successfully generated ECs and MPCs from type 1 diabetic patient-derived hiPS cell lines and use them to generate blood vessels in vivo, which is an important milestone toward clinical translation of this approach.
Evaluation of Optical Detection Platforms for Multiplexed Detection of Proteins and the Need for Point-of-Care Biosensors for Clinical Use (2014)

This review investigates optical sensor platforms for protein multiplexing, the ability to analyze multiple analytes simultaneously. Multiplexing is becoming increasingly important for clinical needs because disease and therapeutic response often involve the interplay between a variety of complex biological networks encompassing multiple, rather than single, proteins. Multiplexing is generally achieved through one of two routes, either through spatial separation on a surface (different wells or spots) or with the use of unique identifiers/labels (such as spectral separation-different colored dyes, or unique beads-size or color). The strengths and weaknesses of conventional platforms such as immunoassays and new platforms involving protein arrays and lab-on-a-chip technology, including commercially-available devices, are discussed. Three major public health concerns are identified whereby detecting medically-relevant markers using Point-of-Care (POC) multiplex assays could potentially allow for a more efficient diagnosis and treatment of diseases.
Evolution of the flow through a turning mid turbine frame applied between a transonic hp-turbine stage and a counter-rotating LP-Turbine (2011)

To enhance the performance of modern high-bypass jet engines a promising approach is to replace the low pressure-vane row arranged downstream of a strutted intermediate turbine diffuser (mid turbine frame) by the application of turning struts and to integrate functionalities such as bearing supports, lubrication pipes, engine mounts and aggressive duct designs. Thus the weight may be reduced which results in a lower specific fuel consumption and reduced CO2-emissions. The additional functions of the mid turbine frame (MTF) structures lead to constraints like a minimum required strut thickness leading to a maximum possible number of struts. Therefore a highly three-dimensional design of the airfoils and the duct, respectively, is necessary to reduce strong secondary flow effects and further to provide suitable flow angle and Mach number for the following low pressure turbine (LPT). A future area of application for mid turbine frames with turning struts, so-called turning mid turbine frames (TMTF), may also be in direct-drive open-rotor engine architectures. There the LPT with contra-rotating stator and rotor blades is arranged at relatively large radii and the rear bearings of these shafts are supported in the TMTF. The present paper examines a configuration consisting of a transonic HPT stage followed by an S-shaped TMTF and a counter-rotating LPT rotor at larger diameter. The test arrangement was applied in the newly designed continuously operating two-spool-two-stage turbine rig at Graz University of Technology. To gain a better understanding of the turbulent and unsteady flow field through the MTF which is dominated by strong secondary flows as well as the complex interactions between the components, detailed experimental investigations were performed by means of five-hole-probes at duct inlet and exit as well as downstream the LPT. The results from this unique HPT-Duct-LPT configuration will allow the designers to investigate how to reach optimal designs. This paper is part of the EU-project DREAM (ValiDation of Radical Engine Architecture SysteMs, contract No. ACP7-GA-2008-211861).
[Fetal lung maturity and fetal flowmetry changes]. (2000)

Our data suggest that fetuses with an UA/MCA ratio > 95 degrees are not protected from neonatal RDS, as usually felt, but show a delay in FLM, particularly in pregnancies > 33 wks.
Compact, low-cost Ti:Al_2O_3 laser for in vivo ultrahigh-resolution optical coherence tomography (2003)

A compact, low-cost, prismless Ti:Al2O3 laser with 176-nm bandwidth (FWHM) and 20-mW output power was developed. Ultrahigh-resolution ophthalmic optical coherence tomography (OCT) ex vivo imaging in an animal model with approximately 1.2-microm axial resolution and in vivo imaging in patients with macular pathologies with approximately 3-microm axial resolution were demonstrated. Owing to the pump laser, this light source significantly reduces the cost of broadband OCT systems. Furthermore, the source has great potential for clinical application of spectroscopic and ultrahigh-resolution OCT because of its small footprint (500 mm x 180 mm including the pump laser), user friendliness, stability, and reproducibility.
The Electrical Hopkins (1996)

When Randall Jarrell said that a poet is someone standing in a thunderstorm hoping to be struck by lightning, he might have been speaking for Gerard Manley Hopkins. Indeed he might just possibly have been thinking of the Hopkins sonnet beginning 'The shepherd's brow,' in which the poet envies the epic vision supposedly granted shepherds exposed to an electrical storm's 'horror' and 'havoc.' No less than the poets of Jarrell's generation, Hopkins was heir to the Romantic hunger for unmediated experience, figured as direct contact between the poet and some powerful, often dangerous reality, and like a number of them was given to representing such contact as the closing of a circuit—a visionary act of electrification, perhaps of electrocution. This essay will explore the implications of distinctively electrical inspiration, as developed in Hopkins' two best-known poems, The Wreck of the Deutschland and 'The Windhover.'
Relation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV (2000)

Summary: We evaluated the potential effectiveness of a spermicide cationic surfactant, benzalkonium chloride (BZK), to prevent the transmission of simian immunodeficiency virus (SIV) after intravaginal inoculation in 12 cynomolgus macaques. The inoculation procedure involved deposition of 6.7 ivag-AID50 of cell-free SIVmac251 into the receiving vagina, four times over a 2-week period, at the end of the luteal phase of the menstrual cycle. Six randomly selected females received vaginally foam containing BZK (7.37%, wt/wt) before each inoculation (BZK group), whereas the remaining were not pretreated (control group). In controls, 5 animals presented persistent SIV infection and 1 had a transient viremia. The number of uninfected animals was higher in the BZK group (6 of 6) than in controls (0 of 6). These findings demonstrate that BZK placed in the vaginal receptacle prior to SIV inoculation provides a significant protection in vivo. The wide spectrum of antimicrobial activities of BZK (including HIV) in addition to its efficiency to block the transmucosal passage of SIV in the macaque model qualifies this drug as an attractive topical microbicide to prevent sexually transmitted infections in humans.
Molecular programming with a transcription and translation cell-free toolbox: from elementary gene circuits to phage synthesis. (2012)

University of Minnesota Ph.D. dissertation. August 2012. Major: Physics. Advisor: Vincent Noireaux. 1 computer file (PDF); vii, 107 pages.