gebhart/patrepeval huggingface dataset:
A downstream regulatory element located within the coding sequence mediates autoregulated expression of the yeast fatty acid synthase gene FAS2 by the FAS1 gene product (2001)

The fatty acid synthase genes FAS1 and FAS2 of the yeast Saccharomyces cerevisiae are transcriptionally co-regulated by general transcription factors (such as Reb1, Rap1 and Abf1) and by the phospholipid-specific heterodimeric activator Ino2/Ino4, acting via their corresponding upstream binding sites. Here we provide evidence for a positive autoregulatory influence of FAS1 on FAS2 expression. Even with a constant FAS2 copy number, a 10-fold increase of FAS2 transcript amount was observed in the presence of FAS1 in multi-copy, compared to a fas1 null mutant. Surprisingly, the first 66 nt of the FAS2 coding region turned out as necessary and sufficient for FAS1-dependent gene expression. FAS2-lacZ fusion constructs deleted for this region showed high reporter gene expression even in the absence of FAS1, arguing for a negatively-acting downstream repression site (DRS) responsible for FAS1-dependent expression of FAS2. Our data suggest that the FAS1 gene product, in addition to its catalytic function, is also required for the coordinate biosynthetic control of the yeast FAS complex. An excess of uncomplexed Fas1 may be responsible for the deactivation of an FAS2-specific repressor, acting via the DRS.
Mbari Is a Dance (1969)

Cet article est le second d'une serie de trois. L'etude des maisons mbari des Ibo examine la forme et la richesse du symbolisme de la maison enfin terminee (Mbari is Life, African Arts/Arts d'Afrique, Printemps 1969). Elle passe alors a une discussion des activites rituelles et de la construction proprement dite qui precedent les ceremonies d'inauguration du mbari. Vu de l'interieur du systeme des valeurs Ibo, il est evident que le processus de l'edification qui les entoure s'avere plus important que l'aspect formal des mbari.
Radiological follow-up of transluminally inserted vascular endoprostheses: an experimental study using expanding spirals. (1984)

A technique for transluminal implantation of vascular endoprostheses was developed. Using a suitable instrument, 160 spiral-shaped prostheses of various forms and sizes were torsion-reduced in diameter and transluminally inserted under fluoroscopy in our study population consisting of 65 dogs and five calves. At the target, the spirals were enlarged and released from the carrier, whereupon they attached themselves to the vessel wall by elastic expansion. We implanted spirals into the vena cava or the thoracic and abdominal aorta, using the infrarenal aorta and the jugular or femoral vein for access. Angiography (the maximum follow-up was two years) demonstrated that the operation was reproducable and that it could be planned. Angiography also demonstrated that the position of the spiral prosthesis was stable and that the spiral did not lead to stenosis, thrombosis, or perforation, providing an adequate technique was used. The side branches of the main vessels remained patent, even with several spiral coils across their orifices. The method can be clinically implemented and lends itself to many applications in the vascular field.
Adsorption and Photocatalyzed Oxidation of Methylated Arsenic Species in TiO<sub>2</sub> Suspensions (2007)

Monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) are used as herbicides in the agriculture industry. We have demonstrated that MMA and DMA are readily degraded upon TiO2 photocatalysis. DMA is oxidized to MMA as the primary oxidation product, which is subsequently oxidized to inorganic arsenate, As(V). The adsorption of MMA and DMA on Ti02 surface was measured as a function of initial arsenic concentration and solution pH. The pH of the solution influences the adsorption and photocatalytic degradation to a similar degree, due to the speciation of the arsenic substrates and surface charge of TiO2 as a function of pH. The mineralization of MMA and DMA by TiO2 photocatalysis follows the Langmuir-Hinshelwood kinetic model. Addition of tert-butyl alcohol, a hydroxyl radical scavenger, during TiO2 photocatalysis dramatically reduces the rate of degradation, indicating that *OH is the primary oxidant. For dilute solutions, TiO2 may also be applicable as an absorbent for direct removal of a variety of arsenic species, namely As(III), As(V), MMA, and DMA, all of which are strongly adsorbed, thus eliminating the need for a multistep treatment process.
On the Design of a Parallel Object-Oriented Data Mining Toolkit (2000)

As data mining techniques are applied to ever larger data sets, it is becoming clear that parallel processors will play an important role in reducing the turn-around time for data analysis. In this paper, we describe the design of a parallel object-oriented toolkit for mining scientic data sets. After a brief discussion of our design goals, we describe our overall system design that uses data mining to nd useful information in raw data in an iterative and interactive manner. Using decision trees as an example, we illustrate how the need to support exibility and extensibility can make the parallel implementation of our algorithms very challenging. We describe the solution approaches we are considering to address these challenges. As this is work in progress, we also present some preliminary results using an astronomy data set. 1. INTRODUCTION Parallel data mining is the exploitation of ne grained parallelism in data mining, using tightly-coupled processors connected by a high-band...
Optimizing light transport in scintillation crystals for time-of-flight PET: an experimental and optical Monte Carlo simulation study (2015)

Achieving excellent timing resolution in gamma ray detectors is crucial in several applications such as medical imaging with time-of-flight positron emission tomography (TOF-PET). Although many factors impact the overall system timing resolution, the statistical nature of scintillation light, including photon production and transport in the crystal to the photodetector, is typically the limiting factor for modern scintillation detectors. In this study, we investigated the impact of surface treatment, in particular, roughening select areas of otherwise polished crystals, on light transport and timing resolution. A custom Monte Carlo photon tracking tool was used to gain insight into changes in light collection and timing resolution that were observed experimentally: select roughening configurations increased the light collection up to 25% and improved timing resolution by 15% compared to crystals with all polished surfaces. Simulations showed that partial surface roughening caused a greater number of photons to be reflected towards the photodetector and increased the initial rate of photoelectron production. This study provides a simple method to improve timing resolution and light collection in scintillator-based gamma ray detectors, a topic of high importance in the field of TOF-PET. Additionally, we demonstrated utility of our Monte Carlo simulation tool to accurately predict the effect of altering crystal surfaces on light collection and timing resolution.
Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis (2004)

Systolic myocardial dysfunction is present in 44% of patient with severe sepsis or septic shock. In this setting, brain natriuretic peptide seems useful to detect myocardial dysfunction, and high plasma levels appear to be associated with poor outcome of sepsis, but further studies are needed.
Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex (2010)

Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A-C (1-3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1-3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells.
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease (2012)

The purpose of our study was to determine the relationship between voltage-dependent anion channel 1 protein (VDAC1) and amyloid beta (Aβ) and phosphorylated tau in Alzheimer's disease (AD). Using brain specimens from AD patients, control subjects and 6-, 12- and 24-month-old Aβ precursor protein (APP) transgenic mice, we studied VDAC1 protein levels. Further, we also studied the interaction between VDAC1 and Aβ (monomers and oligomers) and phosphorylated tau, using cortical issues from AD patients, control subjects, APP, APP/PS1 and 3XTg.AD mice. We also studied age- and VDAC1-linked, mutant APP/Aβ-induced mitochondrial dysfunction in APP and non-transgenic wild-type (WT) mice. We found progressively increased levels of VDAC1 in the cortical tissues from the brains of patients with AD, relative to control subjects, and significantly increased levels of VDAC1 in the cerebral cortices of 6-, 12- and 24-month-old APP transgenic mice, relative to the age-matched control WT mice. Interestingly, we found VDAC1 interacted with Aβ and phosphorylated tau in the brains from AD patients and from APP, APP/PS1 and 3XTg.AD mice. We found progressively increased mitochondrial dysfunction in APP mice relative to WT mice. These observations led us to conclude that VDAC1 interacts with Aβ, and phosphorylated tau may in turn block mitochondrial pores, leading to mitochondrial dysfunction in AD pathogenesis. Based on current study observations, we propose that reduced levels of VDAC1, Aβ and phosphorylated tau may reduce the abnormal interaction between VDAC1 and APP, VDAC1 and Aβ, and VDAC1 and phosphorylated tau; and that reduced levels of VDAC1, Aβ and phosphorylated tau may maintain normal mitochondrial pore opening and pore closure, ultimately leading to normal mitochondrial function, mitochondria supplying ATP to nerve terminals and boosting synaptic and cognitive function in AD.
Cross layer design in 802.16d (2009)

WiMAX based wireless mesh network aims to provide broadband wireless for the last-mile access. It has high-speed data rate for large spanning area and is the key topology for the next generation wireless networking. The WIMAX mesh network (WMN) is developed with the use of base station (BS) as the main controller. However, the effects of the interferences from the transmission of the neighboring nodes within the mesh networks are inevitable and critical because all the nodes are using the same medium to communicate. This paper presents a cross-layer design that rely on the routing information in network (NET) layer and the scheduling slots in the medium access control (MAC) layer. The construction of the routing path with multi-channel single transceiver system and single channel single transceiver is proposed together with centralized scheduling (CS) algorithms that reduce the existing interferences in WMN. The analysis results show that the proposed algorithms have significantly improved the system performance in term of length of scheduling, channel utilization ratio (CUR), and throughput of the system.
Indicating Supported Media Features Using Extensions to DSN and MDN (1999)

There is a need in Internet mail and Internet fax for a recipient to indicate the media features it supports so that messages can be generated by senders without exceeding the recipient's abilities.
Modal Emissions Modeling: A Physical Approach (1996)

Mobile source emission models currently used by state and federal agencies (e.g., Environmental Protection Agency's MOBILE and California Air Resources Board's EMFAC) are often inadequate for analyzing the emissions impact of various transportation control measures, intelligent transportation systems, alternative fuel vehicles, and more sophisticated inspection/maintenance programs contained in most state air quality management plans. These emission models are based on the assumption that vehicle running exhaust emissions can be represented as integrated values for a specific driving cycle, and then later adjusted by speed correction factors. What is needed in addition to these "regional-type" mobile source models is an emissions model that considers at a more fundamental level the modal operation of a vehicle (i.e., emissions that directly relate to vehicle operating modes such as idle, steady-state cruise, various levels of acceleration/deceleration, and so forth). A new modal-emissions modeling approach that is deterministic and based on analytical functions that describe the physical phenomena associated with vehicle operation and emissions productions is presented. This model relies on highly time-resolved emissions and vehicle operation data that must be collected from a wide range of vehicles of varying emission control technologies. Current emission modeling techniques are discussed and the modeling approach and implementation plan for a new, three-year NCHRP Project entitled "Development of a Modal Emissions Model" are described.
Synthesis and antihypertensive activity of 1-amino-3,4-dihydroisoquinolines (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antihypertensive activity of 1-amino-3,4-dihydroisoquinolinesGuy D. Diana, W. Banks Hinshaw, and Harlan E. LapeCite this: J. Med. Chem. 1977, 20, 3, 449–452Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://pubs.acs.org/doi/10.1021/jm00213a025https://doi.org/10.1021/jm00213a025research-articleACS PublicationsRequest reuse permissionsArticle Views290Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
‘Flavor‐fade’ and Off‐Flavors in Ground Roasted Peanuts As Related to Selected Pyrazines and Aldehydes (1996)

ABSTRACT Headspace volatiles from ground roasted Florunner medium peanuts, stored at 65°C for 1–68 days, were separated and identifled by GC/MS. Selected pyrazines, resulting from Maillard browning and selected aldehydes from autoxidation were evaluated to determine their mechanistic contributions to peanut ‘flavor‐fade.’ The 2,6‐dimethylpyrazine, 2‐methylpyrazine, 2‐ethyl‐5‐methyl or 6‐methylpyrazine, 2,3,5‐trimethylpyrazine, and pentanal remained constant during storage (p < 0.05). Flavor scores for ‘roasted peanut’ decreased slightly, then leveled off and hex‐anal, heptanal, octanal and nonanal increased during storage (p < 0.05). Oxidative ‘rancid’ flavor scores and thiobarbituric acid values also increased during storage (p < 0.05). Based on results, the ‘flavor‐fade’ of stored roasted peanuts is due to masking of pyrazines and other ‘roasted peanut’ flavor compounds by large quantities of low‐molecular weight aldehydes from lipid autoxidation, and not due to polymerization and/or degradation of the pyrazines.
Prognostic significance of erythropoietin expression in human endometrial carcinoma (2004)

Hypoxia-inducible autocrine Epo signaling in endometrial carcinoma may contribute to tumor progression and increased aggressiveness. Increased Epo expression in endometrial carcinomas may be an independent prognostic and/or predictive factor.
Lipid and terpenoid metabolites of the Gorgonian Plexaura flava (1982)

Six novel branched-chain lipids containing a γ-lactone ring have been isolated from the Gorgonian Plexaura flava. These compounds were accompanied by two new terpenoids of mixed biosynthesis.
Modern Differential Geometry of Curves and Surfaces with Mathematica (2006)

From the Publisher:
The Second Edition combines a traditional approach with thesymbolic manipulation abilities of Mathematica to explain and develop the classical theory of curves and surfaces. You will learn to reproduce and study interesting curves and surfaces - many more than are included in typical texts - using computer methods. By plotting geometric objects and studying the printed result, teachers and students can understand concepts geometrically and see the effect of changes in parameters.
Modern Differential Geometry of Curves and Surfaces with Mathematica explains how to define and compute standard geometric functions, for example the curvature of curves, and presents a dialect of Mathematica for constructing new curves and surfaces from old. The book also explores how to apply techniques from analysis.
Although the book makes extensive use of Mathematica, readers without access to that program can perform the calculations in the text by hand. While single- and multi-variable calculus, some linear algebra, and a few concepts of point set topology are needed to understand the theory, no computer or Mathematica skills are required to understand the concepts presented in the text. In fact, it serves as an excellent introduction to Mathematica, and includes fully documented programs written for use with Mathematica.
Ideal for both classroom use and self-study, Modern Differential Geometry of Curves and Surfaces with Mathematica has been tested extensively in the classroom and used in professional short courses throughout the world.
Rabies Virus Glycoprotein Analogs: Biosynthesis in <i>Escherichia coli</i> (1983)

The surface of rabies virus is composed of an approximately 60,000 dalton glycoprotein, in which most of the antigenic and immunogenic determinants of the virus reside. We have constructed plasmids for the direct expression in Escherichia coli of the mature full length rabies glycoprotein gene and also for the expression of a glycoprotein gene which has been truncated to exclude the coding region for a hydrophobic, possibly transmembrane, domain of the protein. Escherichia coli harboring the plasmids synthesize analog proteins which conform by several biochemical and antigenic criteria to rabies glycoprotein.
Soldering technology — decade of developments (1984)

Developments in soldering technology during the past ten years have mostly occurred in the electronics industry because of the need to ensure high reliability of soldered joints in such applications. This review covers in detail work concerned with the metallurgy of soft solders including mechanicalproperty studies, and also basic studies on the physical and chemical nature of the process by which solder wets the basis metals and the means of achieving rapid wetting. Fluxes are essential in the soldering process and more active formulations have been developed to improve wetting or overcome poor solderability of surfaces. Health and safety aspects of these and other materials used in the soldering process are discussed. New soldering techniques such as vapour phase soldering using solder creams are included and the question of the routine testing of incoming components for adequate solderability is discussed: the various solderability tests and their application are described. Attention is also given to methods of checking the quality of soldered joints in order to ensure reliability in service and standards relevant to the science of soldering technology are listed.
Intraoperative Testing of Selectivity of Spiral Nerve Cuff Electrodes (2005)

Nerve cuff electrodes were used intraoperatively to stimulate peripheral nerves to test electrode selectivity in the human upper extremity. Subjects were recruited from patients undergoing upper extremity nerve repair procedures. The nerves were stimulated through different contacts in the cuff and with varying parameters. Data was recorded to estimate stimulation threshold and determine selectivity data. Thresholds appeared to be higher than anticipated based on previous cat data. Preliminary selectivity was demonstrated on several nerves
Quantitative Determination of Peptides Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (2005)

A method is described for the quantitative determination of peptides using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Known limitations imposed by crystal heterogeneity, peptide ionization differences, data handling, and protein quantification with MALDI-TOF mass spectrometry are addressed in this method with a "seed crystal" protocol for analyte-matrix formation, the use of internal protein standards, and a software package called maldi_quant. The seed crystal protocol, a new variation of the fast-evaporation method, minimizes crystal heterogeneity and allows for consistent collection of protein spectra. The software maldi_quant permits rapid and automated analysis of peak intensity data, normalization of peak intensities to internal standards, and peak intensity deconvolution and estimation for vicinal peaks. Using insulin proteins in a background of other unrelated peptides, this method shows an overall coefficient of variance of 4.4%, and a quantitative working range of 0.58-37.5 ng bovine insulin per spot. Coupling of this methodology to powerful analytical procedures such as immunoprecipitation is likely to lead to the rapid and reliable quantification of biologically relevant proteins and their closely related variants.
Stem and progenitor cells in biostructure of blood vessel walls (2013)

Development of vascular and hematopoietic systems during organogenesis occurs at the same time. During vasculogenesis, a small part of cells does not undergo complete differentiation but stays on this level, "anchored" in tissue structures described as stem cell niches. The presence of blood vessels within tissue stem cell niches is typical and led to identification of niches and ensures that they are functioning. The three-layer biostructure of vessel walls for artery and vein, tunica: intima, media and adventitia, for a long time was defined as a mechanical barrier between vessel light and the local tissue environment. Recent findings from vascular biology studies indicate that vessel walls are dynamic biostructures, which are equipped with stem and progenitor cells, described as vascular wall-resident stem cells/progenitor cells (VW-SC/PC). Distinct zones for vessel wall harbor heterogeneous subpopulations of VW-SC/PC, which are described as "subendothelial or vasculogenic zones". Recent evidence from in vitro and in vivo studies show that prenatal activity of stem and progenitor cells is not only limited to organogenesis but also exists in postnatal life, where it is responsible for vessel wall homeostasis, remodeling and regeneration. It is believed that VW-SC/PC could be engaged in progression of vascular disorders and development of neointima. We would like to summarize current knowledge about mesenchymal and progenitor stem cell phenotype with special attention to distribution and biological properties of VW-SC/PC in biostructures of intima, media and adventitia niches. It is postulated that in the near future, niches for VW-SC/PC could be a good source of stem and progenitor cells, especially in the context of vessel tissue bioengineering as a new alternative to traditional revascularization therapies.