gebhart/patrepeval huggingface dataset:
Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA. (1994)

Constitutive major histocompatibility complex (MHC) class II gene expression is tightly restricted to antigen presenting cells and is under developmental control. Cells of the B cell lineage acquire the capacity to express MHC class II genes early during ontogeny and lose this property during terminal differentiation into plasma cells. Cell fusion experiments have suggested that the extinction of MHC class II expression in plasma cells is due to a dominant repression, but the underlying mechanisms are not understood. CIITA was recently identified as an MHC class II transactivator that is essential for MHC class II expression in B lymphocytes. We show here that inactivation of MHC class II genes in plasmocytes is associated with silencing of the CIITA gene. Moreover, experimentally induced expression of CIITA in plasmocytes leads to reexpression of MHC class II molecules to the same level as that observed on B lymphocytes. We therefore conclude that the loss of MHC class II expression observed upon terminal differentiation of B lymphocytes into plasmocytes results from silencing of the transactivator gene CIITA.
Integral Sliding Mode for the Torque-Vectoring Control of Fully Electric Vehicles: Theoretical Design and Experimental Assessment (2014)

This paper presents an integral sliding mode (ISM) formulation for the torque-vectoring (TV) control of a fully electric vehicle. The performance of the controller is evaluated in steady-state and transient conditions, including the analysis of the controller performance degradation due to its real-world implementation. This potential issue, which is typical of sliding mode formulations, relates to the actuation delays caused by the drivetrain hardware configuration, signal discretization, and vehicle communication buses, which can provoke chattering and irregular control action. The controller is experimentally assessed on a prototype electric vehicle demonstrator under the worst-case conditions in terms of drivetrain layout and communication delays. The results show a significant enhancement of the controlled vehicle performance during all maneuvers.
Purification and Developmental Analysis of an Extracellular Proteinase from Young Leaves of Soybean (1995)

A proteinase present in intercellular wash fluids from leaves of Glycine max has been purified 600-fold to electrophoretic homogeneity. The native protein is monomeric with a molecular mass of 60 kD, as estimated by denaturing gel electrophoresis, and has an isoelectric point of 7.7. The enzyme has a pH optimum of 9.5 when assayed with Azocoll as a substrate. The proteolytic activity is inhibited by p-chloromercuribenzoic acid and mercuric chloride and requires the presence of reducing agents. The enzyme activity is refractory to other classical sulfhydryl proteinases. The soybean leaf endoproteinase is present within the extracellular space of young leaves, and a portion is bound to the cell wall. Western blot analysis and activity measurements show that the enzyme is present only during the first 15 d postemergence of the leaf and is therefore under strict developmental control. We suggest that the enzyme may play a critical role in the extracellular milieu during rapid cell growth and leaf expansion.
Softeners and Antisofteners<sup>1</sup> (1928)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSofteners and Antisofteners1Erle C. ZimmermanCite this: Ind. Eng. Chem. 1928, 20, 8, 812–813Publication Date (Print):August 1, 1928Publication History Published online1 May 2002Published inissue 1 August 1928https://pubs.acs.org/doi/10.1021/ie50224a011https://doi.org/10.1021/ie50224a011research-articleACS PublicationsRequest reuse permissionsArticle Views19Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Characterization of materials using an ultraviolet radiometric beamline at SURF III (2000)

The completion of the upgrade of the synchrotron facilities at the National Institute of Standards and Technology (NIST) has yielded a better characterized broadband source of ultraviolet (UV) radiation at the Synchrotron Ultraviolet Radiation Facility (SURF III). A cryogenic-radiometer-based facility that uses the monochromatized radiation from SURF III has been established on beamline 4 (BL-4) to characterize detectors and optical materials in the wavelength range 125 nm to 325 nm. This upgraded cryogenic radiometry facility will be used to measure the spectral responsivity of detectors in the UV with a relative standard uncertainty of less than 10−2. To demonstrate the capability of BL-4, we have performed a transmittance measurement of calcium fluoride (CaF2). Accurate transmittance measurements of optical materials in the UV are urgently needed to evaluate which materials are the best choices for use in making lenses for UV lithography. A study of CaF2 in spectral transmittance, surface scattering, and surface absorption is presented.
Local anesthetic effect of pellitorine, an active compound isolated from Cha-plu fruit (Piper sarmentosum Roxb.) (2003)

To investigate local anesthetic effect of a semi-purified compound, containing mainly pellitorine, isolated from piper sarmentosum Roxb. on isolated frog sciatic nerves. In addition, in vivo effect of the test compound was further investigated in mouse tail flick test and twitch-response test in guinea pig's skin. The test compound was dissolved in 0.1 M hydroxypropyl-beta-cyclodextrin in Ringer's solution and being applied onto frog sciatic nerve. It was found that pellitorine in the concentration of 10-25 mM exerted a concentration-dependent manner manner and reversible blockade of supramaximally electrical-evoked action potential of isolated frog sciatic nerves. Complete block electrical-evoked action potential exerted by 25 mM of pellitorine and 30 mM of lidocaine was achieved at 73.75+-2.26 min and 7.50+-0.94 min respectively. Further investigation in mouse tail flick test, using analgesia meter, revealed in vivo local anesthetic effect of test substances which was injected into mouse's tail base. The EC[subscript 50] of pellitorine and lidocaine in this model were found to be 16 and 12 mM, respectively. This observation was subsequently confirmed by twitch response in which the test substances were infiltrated intradermally on the back of guinea pig and pricking was used to probe for response to pain. Apparently, pellitorine (3-14 mM) as well as lidocaine (4-16 mM), elicited analgesic effect with the duration of sensory block of about 30-50 min. Based on the results obtained it can be concluded that pellitorine possesses in vitro as well as in vivo local anesthetic effects. The finding that the degrees of conduction block elicited by pellitorine or lidocaine on frog sciatic nerve were markedly increased in sodium deficient Ringer's solution, suggesting the similar mode of action of theses two compounds. Further investigation on the effect of pellitorine on sodium channel is required to elucidate the mechanism of local anesthetic observed. In addition toxicity which may arise should also be evaluated and that may lead to a discovery of a local anesthetic from natural source.
Efficient production of antibodies against a mammalian integral membrane protein by phage display (2011)

The application of phage display technology to mammalian proteins with multiple transmembrane regions has had limited success due to the difficulty in generating these proteins in sufficient amounts and purity. We report here a method that can be easily and generally applied to sorting of phage display libraries with multispan protein targets solubilized in detergent. A key feature of this approach is the production of biotinylated multispan proteins in virions of a baculovirus vector that allows library panning without prior purification of the target protein. We obtained Fab fragments from a naïve synthetic antibody phage library that, when engineered into full-length immunoglobulin (Ig)G, specifically bind cells expressing claudin-1, a protein with four transmembrane regions that is used as an entry co-receptor by the hepatitis C virus (HCV). Affinity-matured variants of one of these antibodies efficiently inhibited HCV infection. The use of baculovirus particles as a source of mammalian multispan protein facilitates the application of phage display to this difficult class of proteins.
Plasma DNA microsatellite panel as sensitive and tumor‐specific marker in lung cancer patients (2003)

The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cell lung cancer (SCLC) and 23 nonsmall cell lung cancer (NSCLC) (12 adenocarcinomas, 11 squamous cell carcinomas) and 20 controls. Allelotyping was performed with a selected panel of 12 microsatellites from 9 chromosomal regions 3p21, 3p24, 5q, 9p, 9q, 13q, 17p, 17q and 20q. Plasma DNA allelic imbalance (AI) was found in 88% (30 of 34 patients), with a similar sensitivity in SCLC and NSCLC. In the 24 paired available tumor tissues, 83% (20 of 24) presented at least 1 AI. Among these patients, 85% (17 of 20) presented also at least 1 AI in paired plasma DNA, but the location of the allelic alterations in paired plasma and tumor DNA could differ, suggesting the presence of heterogeneous tumor clones. None of the 20 controls displayed plasma or bronchial DNA alteration. A reduced panel of six markers (at 3p, 5q, 9p, 9q) showed a sensitivity of 85%. Moreover, a different panel of microsatellites at 3p and 17p13 in SCLC and at 5q, 9p, 9q and 20q in NSCLC patients could be specifically used. Analysis of plasma DNA using this targeted panel could be a valuable noninvasive test and a useful tool to monitor disease progression without assessing the tumor.
The Accuracy and Clinical Feasibility of a New Bayesian-Based Closed-Loop Control System for Propofol Administration Using the Bispectral Index as a Controlled Variable (2008)

The Bayesian-based closed-loop control system for propofol administration using the BIS as a controlled variable performed accurate during anesthesia for ambulatory gynecological procedures. This control system is clinical feasibility and can be further validated in clinical practice.
Comparison of atropine and tropicamide in esotropia. (1983)

Forty-one patients with esodeviation (82 eyes) were subjected first to 1% tropicamide and retinoscopy and then to retinoscopy after the use of 0.5% to 1% atropine sulfate in children with esodeviation up to the age of 5 years. The ages ranged from 2 months to 5 years, and the esodeviation ranged from 5 to 50 diopters (D). There were 20 male and 21 female patients. The average difference in the cycloplegia showed +.80 D more hyperopia with atropine than with tropicamide therapy. This was believed to be important, particularly in the young age group with esodeviation.
An octave bandwidth electromagnetic band gap (EBG) structure (2012)

This paper presents a way in which a broadband EBG structure can be formed by stacking uniform EBG (electromagnetic band gap) structures. The design is validated by using it with a broadband monopole antenna. The paper shows the applications of stacked EBG structure. The performance of the antenna with the stacked EBG is compared with that of a uniform EBG.
Phospholipase A2 in serum and colonic mucosa in ulcerative colitis (1999)

Group II phospholipase A2 is involved in the pathogenesis of various inflammatory diseases and in the host defence against bacteria. The enzyme is expressed in the epithelial cells of colonic mucosa in ulcerative colitis. In this study, we measured the concentration of group II phospholipase A2 in serum and colonic mucosa of patients with ulcerative colitis of different severity and of control patients without any inflammatory disease. The activity of ulcerative colitis was assessed by endoscopy. The concentration of group II phospholipase A2 was measured with an immunoassay. The concentrations of group II phospholipase A2 in serum and colonic mucosa were significantly higher in patients with active and inactive ulcerative colitis than in controls. However, the group II phospholipase A2 levels did not separate patients with different disease activity. The concentration of group II phospholipase A2 in colonic mucosa corresponded with the mucosal inflammatory activity (higher in active colonic areas) intra-individually, but not between different patients with ulcerative colitis. Serum group II phospholipase A2 values were above the normal reference range more often than the values of 11 standard laboratory blood tests widely used for the follow-up of inflammatory activity in ulcerative colitis. These results indicate that the concentration of group II phospholipase A2 is increased in serum and colonic mucosa of patients with ulcerative colitis. The clinical value of the measurement of group II phospholipase A2 in the follow-up of ulcerative colitis remains to be clarified.
Relative phase information for detecting human speech and spoofed speech (2015)

The detection of human and spoofed (synthetic/converted) speech has started to receive more attention. In this study, relative phase information extracted from a Fourier spectrum is used to detect human and spoofed speech. Because original/natural phase information is almost entirely lost in spoofed speech using current synthesis/conversion techniques, a modified group delay based feature, the frequency derivative of the phase spectrum, has been shown effective for detecting human speech and spoofed speech. The modified group delay based phase contains both the magnitude spectrum and phase information. Therefore, the relative phase information, which contains only phase information, is expected to achieve a better spoofing detection performance. In this study, the relative phase information is also combined with the Mel-Frequency Cepstral Coefficient (MFCC) and modified group delay. The proposed method was evaluated using the “ASVspoof 2015: Automatic Speaker Verification Spoofing and Countermeasures Challenge” dataset. The results show that the proposed relative phase information significantly outperforms the MFCC and modified group delay. The equal error rate (EER) was reduced from 1.74% of MFCC, 0.83% of modified group delay to 0.013% of relative phase. By combining the relative phase with MFCC and modified group delay, the EER was reduced to 0.002%. Index Terms: Spoofing detection, relative phase information, group delay, GMM, countermeasures
Alcohol Consumption: An Overview of Benefits and Risks (2004)

Published health benefits of regular light-to-moderate alcohol consumption include lower myocardial infarction rates, reduced heart failure rates, reduced risk of ischemic stroke, lower risk for dementia, decreased risk of diabetes and reduced risk of osteoporosis. Numerous complimentary biochemical changes have been identified that explain the beneficial effects of moderate alcohol consumption. Heavy alcohol consumption, however, can negatively affect neurologic, cardiac, gastrointestinal, hematologic, immune, psychiatric and musculoskeletal organ systems. Binge drinking is a significant problem even among moderate drinkers and is associated with particularly high social and economic costs. A cautious approach should be emphasized for those individuals who drink even small amounts of alcohol. Physicians can apply the research evidence describing the known risks and benefits of alcohol consumption when counseling their patients regarding alcohol consumption.
Evaluation of biocompatible products for managing cucurbit powdery mildew (1999)

The biocompatible products AQ10 (hyperparasitic fungus Ampelomyces quisqualis), JMS Stylet-Oil (medium viscosity mineral oil), M-Pede (potassium salts of fatty acids) and Kaligreen (82% potassium bicarbonate) suppressed powdery mildew (Sphaerotheca fusca) on winter squash, muskmelon, and pumpkin and increased yield compared with nontreated plants under field conditions. Applications were started after disease detection. JMS Stylet-Oil most effectively controlled powdery mildew. However, these products did not provide the degree of full-season control or yield increase obtained with the conventional fungicide program of Bravo (chlorothalonil) plus Nova (myclobutanil). For example, in muskmelon on 17 August 1995, 7 days after the third application, powdery mildew severity on upper and lower (under) leaf surfaces was 66 and 80% for untreated, 3 and 13% for Bravo plus Nova, 43 and 44% for JMS Stylet-Oil, 38 and 65% for AQ10, and 53 and 65% for Kaligreen, respectively. Yield (ton/ha) was 22.8, 44.2, 36.4, 40.6, and 38.5, respectively. Sucrose content was 3.5%, 6.6%, 4.6%, 3.2%, and 4.0%, respectively.
Direct Amination of Naphthazarin, Juglone, and Some Derivatives (2007)

Abstract Mono‐ and diamino‐derivatives of naphthazarin, 2‐methoxynaphthazarin, juglone and their methylethers were prepared by reaction with ammonia. The structure of the products was established by NMR studies. Some compounds were tested for cytotoxic activity.
Quantitative interactome analysis reveals a chemoresistant edgotype (2015)

Chemoresistance is a common mode of therapy failure for many cancers. Tumours develop resistance to chemotherapeutics through a variety of mechanisms, with proteins serving pivotal roles. Changes in protein conformations and interactions affect the cellular response to environmental conditions contributing to the development of new phenotypes. The ability to understand how protein interaction networks adapt to yield new function or alter phenotype is limited by the inability to determine structural and protein interaction changes on a proteomic scale. Here, chemical crosslinking and mass spectrometry were employed to quantify changes in protein structures and interactions in multidrug-resistant human carcinoma cells. Quantitative analysis of the largest crosslinking-derived, protein interaction network comprising 1,391 crosslinked peptides allows for 'edgotype' analysis in a cell model of chemoresistance. We detect consistent changes to protein interactions and structures, including those involving cytokeratins, topoisomerase-2-alpha, and post-translationally modified histones, which correlate with a chemoresistant phenotype.
Accurate vehicle position estimation using a Kalman filter and neural network-based approach (2017)

Accurate detection of vehicle position plays an important role in many intelligent transportation systems, especially vehicle-to-vehicle applications. In this paper, we propose an Extended Kalman Filter (EKF) based method to detect Global Positioning System (GPS) errors for such vehicle-based applications. A machine learning methodology is presented for Kalman filter parameter tuning with application to GPS error correction in vehicle positioning. We also present a model free neural network that is trained on past vehicle GPS trajectories to predict the current vehicle position. Experimental results on real-world data show that the proposed system is effective for detecting and reducing GPS errors. The machine learning algorithm for EKF parameter tuning can be implemented through in-vehicle learning, and the proposed GPS error detection method can be implemented for in-vehicle applications.
IoT Driven with Big Data Analytics and Block Chain Application Scenarios (2018)

The Big Data, Block chain and the Internet of Things (IoT) are the key names in the technology development of these eras. There are undoubtedly differences between the three technologies, but there are also firm relationships that increase the system operations, practicability, and adoptability. As the domain Block chain and the Internet of Things (IoT) are just infant domain and, still it's undergoing more and further development events, and the Internet of Things(IoT) is producing a larger set of the data and adopted across the different industries such as healthcare, smart cities development, retail, banking and public administration and real time application forecasting, the well-analyzed data is tremendously valuable the Big Data Analytics will suffice this needs, and on the other side the Block chain will provide more secured transaction of the data, and it provides contracts, and more other applications plus integration and Big Data Analytics can be integrated on top of it. In this paper will focus on the incorporation of the all three technologies or domain, such as Big Data Analytics, Block chain and the Internet of Things (IoT). We concluded that all the three technology Big Data Analytics, Block chain and the Internet of Things (IoT) would play a vital role in resolving each other constraints. Based on our analysis and case studies it will help for future work research.
Hemophilia (1991)

Hemophilia is a hereditary bleeding disorder characterized by Factor VIII (F-VIII) or Factor IX (F-IX) deficiency, bleeding into joints and soft tissues, and an X-linked mode of inheritance. Approximately one third of new cases occur as spontaneous mutations, with no family history of hemophilia. The incidence of hemophilia is about one per 20 000 persons, and one per 10 000 males. DIAGNOSIS Hemophilia A (characterized by F-VIII deficiency) and hemophilia B (characterized by F-IX deficiency) are clinically indistinguishable. Both affect males almost exclusively; both have the same type of bleeding; and, if the usual coagulation screening tests are performed, both are characterized by a prolonged partial thromboplastin time and normal prothrombin time. The template bleeding time is usually normal; this is expected, because the bleeding time is a reflection of platelet numbers, platelet function, capillary integrity, and von Willebrand factor activity, all of which are normal in the case of hemophilia. Hemophilia A and hemophilia B can be separated by assaying F-VIII and F-IX. Because neither F-VIII nor F-IX crosses the placenta, the diagnosis can be made at birth by obtaining a cord blood sample for assay. CARRIER DETECTION AND PRENATAL DIAGNOSIS Carriers of the hemophilia gene may be "obligate" carriers, in the sense that the family pedigree indicates that a particular female must be carrying the gene for F-VIII (or F-IX) deficiency.