gebhart/patrepeval huggingface dataset:
Nocturnal Dexamethasone versus Hydrocortisone for the Treatment of Children with Congenital Adrenal Hyperplasia (2010)

<p/> <p>Classic congenital adrenal hyperplasia affects approximately 1 in 15,000 children. Current treatment strategies using multiple daily doses of hydrocortisone lead to suboptimal outcomes. We tested the hypothesis that nocturnal administration of dexamethasone will suppress the hypothalamic-pituitary-adrenal axis more effectively than standard hydrocortisone treatment by blocking the inherent diurnal secretion of ACTH. We performed a pilot study of five prepubertal patients comparing CAH control during two 24-hour hospitalizations, one on hydrocortisone and the other on dexamethasone. The patterns of adrenal suppression differed markedly between hydrocortisone and nocturnal dexamethasone, with significant suppression of the morning rise in ACTH, 17-hydroxyprogesterone, and androstenedione while on dexamethasone. On hydrocortisone therapy, there is a marked variation in ACTH and adrenal hormones depending on time of day and timing of hydrocortisone administration. Longer-term studies are needed to investigate the lowest effective dose and potential toxicity of nocturnal dexamethasone to determine its utility as a therapy for CAH.</p>
Qubit Noise Spectroscopy for Non-Gaussian Dephasing Environments (2016)

We introduce open-loop quantum control protocols for characterizing the spectral properties of non-Gaussian noise, applicable to both classical and quantum dephasing environments. By engineering a multidimensional frequency comb via repetition of suitably designed pulse sequences, the desired high-order spectra may be related to observable properties of the qubit probe. We prove that access to a high time resolution is key to achieving spectral reconstruction over an extended bandwidth, overcoming the limitations of existing schemes. Non-Gaussian spectroscopy is demonstrated for a classical noise model describing quadratic dephasing at an optimal point, as well as a quantum spin-boson model out of equilibrium. In both cases, we obtain spectral reconstructions that accurately predict the qubit dynamics in the non-Gaussian regime.
Replacement IgG therapy and self-therapy at home improve the health-related quality of life in patients with primary antibody deficiencies (2006)

Adequate IgG replacement therapy means a dramatically improved life situation. Home-therapy programmes should be encouraged, as self-infusions at home further improve health-related quality of life and self-perceived health.
A microfluidic study of mechanisms in the electrophoresis of supercoiled DNA (2008)

In this work, microfluidic chips were used to study the electrophoresis of supercoiled DNA (SC DNA) in agarose. This system allowed us to study the electrophoretic and trapping behaviours of SC DNA of various lengths, at various fields and separation distances. Near a critical electric field the DNA is trapped such that the concentration falls exponentially with distance. The trapping of such circular DNA has been explained in terms of the 'lobster trap' or 'impalement' model where shorter fibres become trapping sites at higher fields, leading to an ongoing (and gradual) increase in trapping with increasing field. By contrast, the present study suggests that under some circumstances the traps have a barrier such that only when the DNA has sufficient energy (at high enough fields) can it become trapped, leading to a sudden transition in behaviours at the critical field. We propose an 'activated impalement' mechanism of trapping in which only at sufficiently high fields is the SC DNA impaled and trapped for long times. The critical electric field appears to be inversely proportional to the length of the DNA molecule, suggesting that the force required to impale the SC DNA is constant.
Genes encoding ribonucleoside hydrolase 1 and 2 from Corynebacterium ammoniagenes (2006)

Two kinds of nucleoside hydrolases (NHs) encoded by rih1 and rih2 were cloned from Corynebacterium ammoniagenes using deoD- and gsk-defective Escherichia coli. Sequence analysis revealed that NH 1 was a protein of 337 aa with a deduced molecular mass of 35,892 Da, whereas NH 2 consisted of 308 aa with a calculated molecular mass of 32 310 Da. Experiments with crude extracts of IPTG-induced E. coli CGSC 6885(pTNU23) and 6885(pTNI12) indicated that the Rih1 enzyme could catalyse the hydrolysis of uridine and cytidine and showed pyrimidine-specific ribonucleoside hydrolase activity. Rih2 was able to hydrolyse both purine and pyrimidine ribonucleosides with the following order of activity -- inosine>adenosine>uridine>guanosine>xanthosine>cytidine -- and was classified in the non-specific NHs family. rih1 and rih2 deletion mutants displayed a decrease in cell growth on minimal medium supplemented with pyrimidine and purine/pyrimidine nucleosides, respectively, compared with the wild-type strain. Growth of each mutant was substantially complemented by introducing rih1 and rih2, respectively. Furthermore, disruption of both rih1 and rih2 led to the inability of the mutant to utilize purine and pyrimidine nucleosides as sole carbon source on minimal medium. These results indicated that rih1 and rih2 play major roles in the salvage pathways of nucleosides in this micro-organism.
Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models (2012)

Candidate biomarkers for PI3K inhibitors have predictive value in preclinical models and show histology-specific alterations in primary tumors, suggesting that distinct biomarker strategies may be required in squamous compared with nonsquamous NSCLC patient populations.
Work-Life Balance, Management Practices, and Productivity (2009)

Abstract A debate is raging all over the developed world about quality of work issues. As unemployment has fallen in the United States and United Kingdom, attention has focused more on the quality rather than quantity of jobs. This has sharpened as women's participation has risen and issues of work–life balance and family-friendly policies have risen up the political agenda. This chapter sheds some empirical light on these debates. It characterizes two opposing views of globalization: the pessimistic and the optimistic view. A hybrid view between these two extremes is found. Finally, looking at U.S. multinationals based in Europe, an intriguing result is found that states that these firms appear to bring over their superior U.S. management practices with them to Europe but then adopt more worker-friendly European work–life balance practices.
Concordance of HOMIM and HOMI<i>NGS</i>technologies in the microbiome analysis of clinical samples (2016)

HOMINGS significantly expanded oral bacterial species identification compared to HOMIM. The genus and species probes, combined in HOMINGS, provided a more comprehensive representation of oral bacterial community, critical for future characterization of oral microbes in distant site infections.
Strukturelle Charakterisierung pseudoenantiomerer <i>cis</i>‐Dioxoosmium(VI)‐Komplexe mit chiralen Diolen und Cinchona‐Alkaloid‐Liganden (1990)

Ausgangspunkt für die Entwicklung von Struktur/Aktivitäts‐Beziehungen bei der asymmetrischen Dihydroxylierung von Olefinen mit OsO 4 in Gegenwart chiraler Amine könnten die Strukturen eines kristallinen Osmatesters und seines Pseudoenantiomers sein. Die Ester wurden aus zwei verwandten trans ‐disubstituierten Olefinen, OsO 4 und den isomeren Alkaloiden 1 und 2 (R′ = p ‐ClC 6 H 4 CO, Aryl = 4‐(6‐Methoxychinolyl)) erhalten. Bemerkenswert sind vor allem die cis ‐Dioxo‐Koordination sowie die räumliche Nähe des äquatorialen Diolat‐Sauerstoffatoms und der CO 2 ‐Gruppe der Chlorbenzoyl‐Einheit. magnified image
Anti-Aids Agents, 1. Isolation and Characterization of Four New Tetragalloylquinic Acids as a New Class of HIV Reverse Transcriptase Inhibitors from Tannic Acid (1989)

Four new tetragalloylquinic acids, 3,5-di-O-galloyl-4-O-digalloylquinic acid, 3,4-di-O-galloyl-5-O-digalloylquinic acid, 3-O-digalloyl-4,5-di-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid, were isolated and characterized from a commercial tannic acid as a new class of human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitor. Compounds 2, 3, and 4 inhibit HIV RT activity 90, 89, and 84% at 100 microM and 73, 70, and 63% at 30 microM, respectively. Compounds 2-5 also inhibit the HIV growth in cells in the range of 61-70% with low cytotoxicity at 25 microM. The HIV cell growth inhibitory effects of these compounds at 25 microM and 6.25 microM (44-57%) are comparable to their effects against the HIV RT at 30 microM and 10 microM, respectively. The inhibitory effect of 3 against DNA polymerases indicates that the selective antiviral action of 3 is determined by more than its action with HIV RT.
<i>ortho-</i>Metalation of Unprotected 3-Bromo and 3-Chlorobenzoic Acids with Hindered Lithium Dialkylamides (2003)

Upon treatment of 3-chloro/bromobenzoic acids with hindered lithium dialkylamides (LDA or LTMP) at -50 degrees C, lithium 3-chloro/bromo-2-lithiobenzoates are generated. These dianions can be trapped as such to afford after electrophilic quenching a variety of simple 2-substituted-3-chloro/bromobenzoic acids. The 3-bromo-2-lithiobenzoate is less stable than the corresponding 3-chloro derivative and partly eliminates lithium bromide, thus setting free lithium 2,3- and 3,4-dehydrobenzoates that can be intercepted in situ with the hindered base.
CONTROL OF APHIDS BY THE FUNGUS, <i>VERTICILLIUM LECANII</i>: EFFECT OF SPORE CONCENTRATION (1980)

In laboratory bioassays, aphid mortality rose while killing time decreased with increasing spore concentrations of Verticillium lecanii. However, in the glasshouse, the ability of the fungus to be spread among aphid populations on chrysanthemums quickly masked the initial effects of spraying different spore concentrations. Hundred‐fold differences in spore concentrations produced equally good control of the aphid, Myzus persicae , in the glasshouse. RÉSUMÉ CONTRÔLE DES PUCERONS PAR LE CHAMPIGNON : VERTICILLIUM LECANII: EFFET DE LA CONCENTRATION EN SPORES Dans des essais de laboratoire, la mortalité des pucerons augmente et est plus rapide quand la concentration en spores de Verticillium lecanii s'élève. Cependant, en serre, la possibilité de pulvériser le champignon sur les populations de pucerons sur chrysanthème a masqué rapidement les effets initiaux des différentes concentrations de spores. Ainsi des concentrations de spores différent de cent fois produisent des résultats aussi bons en serre, contre le puceron Myzus persicae.
Phase II study of human lymphoblastoid interferon in patients with advanced renal carcinoma. (1985)

Twenty-two patients with measurable metastatic renal carcinoma were treated with human alpha lymphoblastoid interferon (Wellferon) (3 million units/m2 of body surface area) im three times a week for 6 weeks; 21 were evaluable for response and toxicity. One patient had a partial regression of disease lasting 39 weeks and another had a minor response. Six patients had partial or minor response in one area but no change in the disease elsewhere (mixed response); they were classified as having stable disease. An additional seven patients had no change in measurable disease and in six the disease progressed. The tumor regressions by metastatic site were four of 14 patients, pulmonary; three of four, soft tissue; one of nine, bone (? soft tissue); none of three, mediastinal; none of four, renal; none of five, liver; and none of ten, other abdominal sites of tumor. The side effects were fever (101 degrees F-103 degrees F), chills, malaise, anorexia, minor (10%-20%) decrease in performance status, and weight loss. We concluded that interferon had some activity against metastatic renal carcinoma, although clinically useful responses were quite infrequent. While lung metastases appeared to be more responsive than those at other sites, careful examination of the data suggests that this simply reflects differences in the bulk of the metastatic disease. Smaller metastases appear more likely to respond than bulky metastases.
Grafting of 2-oxazolines onto cellulose and cellulose diacetate (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGrafting of 2-oxazolines onto cellulose and cellulose diacetateShiro Kobayashi, Mureo Kaku, and Takeo SaegusaCite this: Macromolecules 1988, 21, 7, 1921–1925Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ma00185a007https://doi.org/10.1021/ma00185a007research-articleACS PublicationsRequest reuse permissionsArticle Views232Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic resource allocation for an energy efficient VM architecture for cloud computing (2018)

Minimizing power consumption is a vital consideration in the modern-day development of cloud computing. One of the major challenges reported in cloud computing is the consumption of power by computing resources due to improper allocation of resources over improperly sized virtual machines (VM). In spite of many efforts, the existing solutions are only able to meet the requirement for minimizing power consumption to a limited extent, due to their lack of optimized allocation of computing resources. The primary aim of the proposed work is to make effective use of the computing resources of the cloud for minimizing power consumption. It employs the concept of mapping appropriately sized VMs to a group of tasks in a data center, in order to reduce its power consumption. It involves the clustering of tasks on the basis of their computing requirements and finding a suitably sized VM with the required computing resources. The efficient use of computing resources on the basis of their actual requirements for a group of tasks helps to save a substantial amount of power. The proposed work is evaluated for its superiority over representational techniques using Google cloud traces as benchmark dataset. The experimental results showed an improvement of 8.42% in power consumption compared to representational techniques using fixed-sized VMs in the field. The proposed approach also achieves an improvement of 62% in the number of instances of VMs created for hosting the task workload, while maintaining a low task rejection rate.
Liquid crystal polymers containing macroheterocyclic ligands. 2. Side chain liquid crystal polysiloxanes and polymethacrylates containing 4-(.omega.-alkan-1-yloxy)-4'-(4'-carboxybenzo-15-crown-5)biphenyl side groups (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid crystal polymers containing macroheterocyclic ligands. 2. Side chain liquid crystal polysiloxanes and polymethacrylates containing 4-(.omega.-alkan-1-yloxy)-4'-(4'-carboxybenzo-15-crown-5)biphenyl side groupsVirgil Percec and Randall RodenhouseCite this: Macromolecules 1989, 22, 12, 4408–4412Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/ma00202a003https://doi.org/10.1021/ma00202a003research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A multiple-rotating-clock-phase architecture for digital data recovery circuits using verilog-A (2005)

This paper presents an oversampling data recovery (DR) architecture using Verilog-A that employs a novel multiple-rotating-clock-phase (MRCP) concept for its operation. The MRCP-DR architecture is a variant of the eye-tracking DR architecture. Multiple rotating clock phases, supplied by a delay-locked loop (DLL), establish a window for detecting data edges. As a result, the window width becomes robust against process, voltage and temperature (PVT) variations. The MRCP architecture is tolerant of jitter on the local, blind, free-running oscillator that operates at approximately the incoming data frequency. Behavioral blocks are described and functional simulations are presented using the Verilog-A/Spectre/Cadence platform. The Verilog-A test benches allow the designer to perform system-level what-if analyses and make area, power and performance estimates.
Mapping Brain Structural Connectivities to Functional Networks Via Graph Encoder-Decoder With Interpretable Latent Embeddings (2019)

In this paper, the relationship between functional and structural brain networks is investigated by training a graph encoder-decoder system to learn the mapping from brain structural connectivity (SC) to functional connectivity (FC). Our work leverages a graph convolutional network (GCN) model in the encoder which integrates both nodal attributes and the network topology information to generate new graph representations in lower dimensions. Using brain SC graphs as inputs, the novel GCN-based encoder-decoder system manages to account for both direct and indirect interactions between brain regions to reconstruct the empirical FC networks. In doing so, the latent variables within the system (i.e., the learnt lowdimensional embeddings) capture important information regarding the relation between functional and structural networks. By decomposing the reconstructed functional networks in terms of the output of each graph convolution filter, we can extract those brain regions which contribute most to the generation of FC networks from their SC counterparts. Experiments on a large population of healthy subjects from the Human Connectome Project show our model can learn a generalizable and interpretable SC-FC relationship. Overall, results here support the promising prospect of using GCNs to discover more about the complex nature of human brain activity and function.
3D shape visualization of curved needles in tissue from 2D ultrasound images using RANSAC (2015)

This paper introduces an automatic method to visualize 3D needle shapes for reliable assessment of needle placement during needle insertion procedures. Based on partial observations of the needle within a small sample of 2D transverse ultrasound images, the 3D shape of the entire needle is reconstructed. An intensity thresholding technique is used to identify points representing possible needle locations within each 2D ultrasound image. Then, a Random Sample and Consensus (RANSAC) algorithm is used to filter out false positives and fit the remaining points to a polynomial model. To test this method, a set of 21 transverse ultrasound images of a brachytherapy needle embedded within a transparent tissue phantom are obtained and used to reconstruct the needle shape. Results are validated using camera images which capture the true needle shape. For this experimental data, obtaining at least three images from an insertion depth of 50 mm or greater allows the entire needle shape to be calculated with an average error of 0.5 mm with respect to the measured needle curve obtained from the camera image. Future work and application to robotics is also discussed.
Formation of Ammonia by Insertion of Molecular Nitrogen into Metal-Hydride Bonds. II. Di-μ-imino-bis(dicyclopentadienyltitanium(III)) as a Product of the Reaction between Di-μ-hydrido-bis(dicyclopentadienyltitanium(III)) and Molecular Nitrogen<sup>1</sup> (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of Ammonia by Insertion of Molecular Nitrogen into Metal-Hydride Bonds. II. Di-μ-imino-bis(dicyclopentadienyltitanium(III)) as a Product of the Reaction between Di-μ-hydrido-bis(dicyclopentadienyltitanium(III)) and Molecular Nitrogen1Hans BrintzingerCite this: J. Am. Chem. Soc. 1966, 88, 18, 4307–4308Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September 1966https://pubs.acs.org/doi/10.1021/ja00970a067https://doi.org/10.1021/ja00970a067research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts