gebhart/patrepeval huggingface dataset:
Characterization of melanosome-associated proteins by establishment of monoclonal antibodies and immunoscreening of a melanoma cDNA library through an anti-melanosome antibody (1993)

Monoclonal antibodies against melanosomal components (human melanosome specific antigens; HMSAs) have been developed in our laboratory. HMSA-1-4 recognizes structural matrix proteins of melanosomes. HMSA-5 is identical to TRP-1, equivalent to the b (brown) locus of murine melanocytes and expressed in early stages of melanosomal maturation. HMSA-6 is a protein associated with melanosomes but its role is still unclarified, and HMSA-7 is identical to the lysosomal protein CD63. We have also recently identified p90 calnexin-like, Ca(2+)-binding protein p97 melanotransferrin, and p64 beta-D-galactosidase-like protein associated with melanosomes through immunological screening of our melanocytes (melanoma cells) cDNA library. Approximately 150 genes and 60 loci are known to influence eye, skin and hair colour in mammals. Tyrosinase is a rate-limiting enzyme responsible for melanin synthesis. In addition, tyrosine-related proteins (TRPs) and their genes have been identified and cloned. Tyrosinase and TRPS (e.g., TRP-1; b-locus protein identical to HMSA-5 and TRP-2; dopachrome tautomerase) are synthesized according to underlying genetic programmes, and are up- and/or down-regulated to create various forms of abnormal melanin pigmentation. We herein propose the importance of investigating the role of non-tyrosinase related proteins such as those which we have recently identified.
Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans (2015)

SI-associated transcriptional networks that were deranged predominantly in one ethnic group may explain the distinctive physiological features of glucose homeostasis among AA subjects.
Implantation: Ovulation induction and endometrial steroid receptors (1994)

The endometrial morphology, endometrial steroid receptors and serum steroid hormone concentrations have been studied in 22 infertile women participating in an in-vitro fertilization, gamete intra-Fallopian transfer programme, including nine cases following treatment with gonadotrophin-releasing hormone analogue/human menopausal gonadotrophin/human chorionic gonadotrophin. All patients had normal ovulatory function before treatment and satisfactory response to ovulation induction. Endometrial biopsies were taken in spontaneous and treatment cycles on the fourth day after ovulation had been detected by ultrasound scanning, when endometrial receptors were measured using immunohistochemistry. Histological examination of biopsies in spontaneous cycles showed the majority (20/22) to be 'in-phase', while in two cases luteal phase defect was diagnosed. After ovulation induction, all the biopsies were still morphologically 'in-phase', although a significant reduction had occurred in the nuclear receptor level in both the glands and stroma for both progesterone receptors (gland P = 0.030, stroma P = 0.012 using microscopic analysis; gland P = 0.020, stroma P < 0.001 using a cell analysis system) and oestrogen receptors (gland P = 0.017, stroma P = 0.002 using direct microscopic analysis). This suggests that a reduction in steroid receptors in the endometrium occurs after ovulation induction in the presence of supraphysiological amounts of steroids, which is not associated with detectable morphological changes.
Fermentative Production of Poly(<i>β</i>-<scp>L</scp>-malic acid), a Polyelectrolytic Biopolyester, by<i>Aureobasidium</i>sp (1993)

Many strains of a black yeast, identified as Aureobasidium sp., were isolated by a selective medium, which contained mannitol as a main carbon source, and found to produce an extracellular biopolyester from glucose. The biopolyester was recovered as its calcium salt (61 g) from culture filtrate (1 liter). The acid hydrolysis and the transmethylation of the polyester proved L-malic acid to be its monomeric repeating unit. The saponification of the polyester, however, gave fumaric and maleic acids in about 20% yield, in addition to the malic acid. 1H NMR analysis proved the main-chain ester linkage of the polyester to be β-type. The apparent molecular mass was estimated to be distributed between about 6 and 11 kDa in a buffer (pH 6.8) with a high ionic strength (0.2 M).
Broadening the reactivity spectrum of a phthalocyanine catalyst while suppressing its nucleophilic, electrophilic and radical degradation pathways (2011)

A robust molecule that resists degradation via nucleophilic, electrophilic and radical attacks is described. Coordinated O(2) is reduced catalytically, producing efficiently thyil radicals in spite of the extreme electronic deficiency of the catalyst.
Electrochemical Reactivity of Mg<sub>2</sub>Sn Phases with Metallic Lithium (2004)

Stable (c) and metastable (h) forms of Mg2Sn were prepared as crystallized phases by ball-milling of elemental powders. Through in situ X-ray diffraction measurements, we deduced the reactivity mechanisms of c-Mg2Sn toward lithium. It entails first a monophasic insertion of about one lithium per formula unit into the fcc Sn framework without extrusion of either Mg or Sn, then a biphasic process leading to the formation of cubic Li2MgSn concomitant with a progressive expulsion of Mg, and finally the formation of Li−Mg solid-solution alloys. Upon charging, the poor reversibility of the alloying reaction of Li with Mg leads to a deficit in free Mg, resulting in the formation of a Mg2Sn + Sn mixture, and accounting for the poor cyclability of Mg2Sn/Li cells over the 0.0−1.5 V voltage window. Limiting the cycling to the monophasic process was shown to improve the cycling behavior. Finally, we found that the electrochemical reaction of h-Mg2Sn with Li leads to the same Li2MgSn intermediate and the same subsequent sequence of transformations, resulting in similarly poor capacity retention upon cycling.
On-chip analog signal generator for mixed-signal built-in self-test (2002)

A new method for generating analog signals with very low complexity and hardware requirements has recently been introduced. In this paper, two different silicon implementations are presented and their performance is analyzed through different experimental results. Various ways in which the generators can be used are also demonstrated. Emphasis is placed on the simplicity of the design process and its compact implementation, which are crucial considerations when implementing a Built-In Self-Test (BIST) strategy.
From Rank-N to Rank-1 Face Recognition Based on Motion Similarity (2009)

In this paper, we present a sequential framework using facial motion information as a subsidiary to improve face recognition performance. As is generally known, reasonable static face recognition has been achieved based on subspace reduction techniques. In order to further improve performance, some extra cues, such as temporal variation, are investigated by building dynamic models. We propose a permuted similarity motion feature and integrate it into a sequential recognition system. This system can select the best candidate from the Rank-N candidates picked up in the recognition step based on static appearance parameters by using motion information. The recognition rate of the motion similarity is compared with the motion feature obtained from auto-regressive models to
prove its efficiency. In addition, the sequential system achieves better performance when the motion information is integrated with the static appearance information in a flexible manner.
Unequal Wilkinson power dividers with in-/reverse-phase using lumped-element circuits (2008)

In this paper, we propose in/reverse-phase Wilkinson power dividers with unequal power-split ratio using lumped-element circuits. Although unequal Wilkinson power dividers using the defected ground structure (DGS) have been reported, impedance mismatch between DGS lines and conventional microstrip lines, and radiation may become problems. The proposed divider consists of parallel pi /T-networks and LC-ladder circuits. The designed reversed- phase divider with a power-split ratio of 4 has a practical property of a relative bandwidth of about 14 %. The validity of this design procedure is also shown by EM-simulations and experiments.
Melatonin Treatment for Age-Related Insomnia (2001)

Older people typically exhibit poor sleep efficiency and reduced nocturnal plasma melatonin levels. The daytime administration of oral melatonin to younger people, in doses that raise their plasma melatonin levels to the nocturnal range, can accelerate sleep onset. We examined the ability of similar, physiological doses to restore nighttime melatonin levels and sleep efficiency in insomniac subjects over 50 yr old. In a double-blind, placebo-controlled study, subjects who slept normally (n = 15) or exhibited actigraphically confirmed decreases in sleep efficiency (n = 15) received, in randomized order, a placebo and three melatonin doses (0.1, 0.3, and 3.0 mg) orally 30 min before bedtime for a week. Treatments were separated by 1-wk washout periods. Sleep data were obtained by polysomnography on the last three nights of each treatment period. The physiologic melatonin dose (0.3 mg) restored sleep efficiency (P < 0.0001), acting principally in the midthird of the night; it also elevated plasma melatonin levels (P < 0.0008) to normal. The pharmacologic dose (3.0 mg), like the lowest dose (0.1 mg), also improved sleep; however, it induced hypothermia and caused plasma melatonin to remain elevated into the daylight hours. Although control subjects, like insomniacs, had low melatonin levels, their sleep was unaffected by any melatonin dose.
HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis (2012)

Our results suggest that HSP90 inhibitors interfere with oxidative stress and modulate experimental atherosclerosis development through reduction in pro-oxidative factors.
1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production. (1997)

We hypothesized that 1,25-dihydroxyvitamin D3 (1,25D3) and its analogues may inhibit acute myelogenous leukemia (AML) proliferation by interrupting IL-1beta-mediated growth-stimulatory signals. The incubation of the IL-1beta- responsive AML cell line OCIM2 with 10 nM 1,25D3 reduced growth 80% in liquid culture, and a 100-1000-fold lower concentration of 20-epi analogues (MC1288 and MC1301) was sufficient to achieve similar growth inhibition. The growth inhibition was associated with a rapid but transient downregulation of IL-1beta and IL-1beta-converting enzyme (ICE) mRNAs in 1,25D3- and 20-epi analogue- treated cells, and the 20-epi analogue was more effective than 1,25D3 in repressing ICE expression. An examination of long-term changes in the levels of mature IL-1beta and its precursor revealed that 24-h incubation of OCIM2 with either 1,25D3 or its 20-epi analogues abolished the production of mature IL-1beta. The effect of 1,25D3 and its analogues on growth of fresh bone marrow cells from seven AML patients was tested by a clonogenic assay. Growth inhibition of 60% was reached in only one of seven 1,25D3-treated samples, but all seven samples were inhibited 60-90% by the 20-epi analogue MC1301. Growth inhibition by 1,25D3 and the analogue was reversible by addition of IL-1beta. These results suggest that 1,25D3 and its 20-epi analogues interrupt IL-1beta autocrine growth regulation by inhibiting IL-1beta production and processing but not the response to IL-1beta.
Automated Motion Estimation for 2-D Cine DENSE MRI (2012)

Cine displacement encoding with stimulated echoes (DENSE) is a magnetic resonance (MR) method that directly encodes tissue displacement into MR phase images. This technique has successfully interrogated many forms of tissue motion, but is most commonly used to evaluate cardiac mechanics. Currently, motion analysis from cine DENSE images requires manually delineated anatomical structures. An automated analysis would improve measurement throughput, simplify data interpretation, and potentially access important physiological information during the MR exam. In this paper, we present the first fully automated solution for the estimation of tissue motion and strain from 2-D cine DENSE data. Results using both simulated and human cardiac cine DENSE data indicate good agreement between the automated algorithm and the standard semi-manual analysis method.
An efficient architecture for hardware implementations of image processing algorithms (2009)

This work presents a new performance improvement technique for hardware implementations of non-recursive convolution based image processing algorithms. It combines an advanced data flow technique (instruction reuse) proposed in modern microprocessor design with the value locality of image data to develop a method, window memoization, that increases the throughput with minimal cost in area and accuracy. We implement window memoization as a 2-wide superscalar pipeline such that it consumes significantly less area than conventional 2-wide superscalar pipelines. As a case study, we have applied window memoization to Kirsch edge detector. The average speedup factor was 1.76 with only 25% extra hardware.
Antipodal linearly tapered slot antenna array for millimeter-wave base station in massive MIMO systems (2014)

For massive MIMO systems, it is very challenging to have the large-scale antennas for a compact base station. This paper presents a 36 sub-sectors for a compact millimeter-wave base station. The antenna array for each sub-sector is comprised of 16 planar high-gain dielectric-loaded antipodal linearly tapered slot antenna (ALTSA) elements arranged in a 4×4 configuration. Down to 36 feed ports are required in a base station with 36×16 antennas. The realized gain of the antenna array is 25.6 dBi, and the half-power beam widths (HPBW) are 10.7° and 5.3° in H-plane and E-plane, respectively.
A method for calibrating force transducers against oscillation force (2003)

A method for evaluating the dynamic response of force transducers against an oscillation force is proposed. In the method, a force transducer is connected to a mass by a spring, which generates the oscillating force after the mass is manually hit using a hammer. A pneumatic linear bearing is used to realize linear motion with sufficiently small friction acting on the mass, which is the moving part of the bearing. The inertial force acting on the mass is determined highly accurately by measuring the velocity of the mass using an optical interferometer.
Cholesterol lowering and mortality: the importance of considering initial level of risk. (1993)

Currently evaluated cholesterol lowering drugs seem to produce mortality benefits in only a small proportion of patients at very high risk of death from coronary heart disease. Population cholesterol screening could waste resources and even result in net harm in substantial groups of patients. Overall risk of coronary heart disease should be the main focus of clinical guidelines, and a cautious approach to the use of cholesterol lowering drugs should be advocated. Future trials should aim to clarify the level of risk above which treatment is of net benefit.
Regional Blood Center Automation (1978)

The operation of an automated regional blood center is outlined. The basic approaches used to achieve economical automation that is compatible with existing manual protocols are described. Finally, the role of centralized, automated blood typing is discussed in the context of the operations of The Greater New York Blood Program which involves a central Groupamatic blood typing facility serving four blood centers.
Linguistic Strategies and Cultural Styles for Persuasive Discourse (2018)

Department of English article
Cooperative transmit-power estimation under wireless fading (2008)

We study blind estimation of transmission power of a node based on received power measurements obtained under wireless fading. Specifically, the setup consists of a set of monitors that measure the signal power received from the transmitter, and the goal is to utilize these measurements to estimate the transmission power in the absence of any prior knowledge of the transmitter's location or any statistical distribution of its power. Towards this end, we exploit spatial diversity in received-power measurements and cooperation among the multiple monitoring nodes; based on theoretical analysis we obtain the Maximum Likelihood (ML) estimate, derive fundamental geometrical insights and show that this estimate is asymptotically optimal. Finally, we provide numerical results comparing the performance of the estimators through simulations and on a data-set of field measurements.
Performance limits of stereoscopic viewing systems using active and passive glasses (2002)

In time sequential stereoscopic displays a major contributor to ghost image intensity, as quantified by the system leakage ratio, is due to the persistence of the CRT's phosphor. Two approaches to solving this problem are presented. One is to use a system that has a sectioned electrooptical device mounted directly in front of the CRT. The second is to use phosphors that have less persistence.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Application of multiresolution spatial filters to long-axis tracking (1990)

A method was developed for automatically tracking the long axis of thin objects which have nonuniform width and arbitrary orientation in a two-dimensional image space. This method is used to determine the length of isolated contractile smooth muscle cells, but has applications in other medical areas such as angiographic imaging. Pattern recognition techniques that determine object size and orientation are used to identify the long axis of an imaged object from its responses to difference of Gaussian and orientation filters. This method needs no a priori knowledge of object location, adapts to varying image magnification, requires little human interaction, and yields reproducible results.
Tissue thickness of human stomach measured on excised gastric specimens from obese patients. (2005)

Laparoscopic linear cutting staplers are commonly used in bariatric surgery. Although many staple sizes are available, the clinical results of a staple line vary depending on the staple size and tissue environment. To help surgeons choose the proper staple size as well as establish design parameters for the development of new stapling devices, understanding the mechanical properties of the tissue is necessary. Knowing the distribution of the thickness of the stomach tissue would allow for increased accuracy in defining key design parameters for stapling devices, thus improving their performance in the operating theater. To this end, 50 sleeve/lateral gastrectomy specimens were obtained in a consecutive series from individuals undergoing weight loss surgery. Thickness measurements were performed at six predetermined sites. Results show that stomach thickness varies from thinnest at the proximal end near the esophageal junction to thickest near the pylorus. The data also suggest that the stomach is thinner along the greater curvature. Due to the variation in thickness of the stomach, laparoscopic linear cutting staplers with thicker staples are recommended when transecting the antrum. This thickness data will facilitate the development of devices with appropriate aperture closure for correct tissue compression.
Loop inductance of a Josephson junction interferometer (1980)

In a Josephson junction interferometer, the current flow between the junctions is not uniform along the stripe line. The current is crowded around the junctions and becomes uniform along the strip line only when it is far away from the junction area. The inductance of such a structure with nonuniform current flow is analyzed. Several analytical formulas are derived to calculate the loop inductance of a Josephson junction interferometer.
Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation. (1994)

Overexpression of v-ski blocks the terminal differentiation of chicken erythroblasts, and in cooperation with v-sea causes transformation of these cells, indicating that c-ski may play a role in regulating either proliferation or differentiation in hematopoietic cells. We examined c-ski expression in four different myeloid cell lines which can be induced to differentiate by exposure to phorbol 12-myristate 13-acetate (PMA). Two of the cell lines are multipotent and have the ability to differentiate into either erythrocytes or megakaryocytes (K562 and HEL cells), one cell line differentiates exclusively into megakaryocytes (CHRF-288-11), and the fourth cell line differentiates into either monocytes or granulocytes (HL-60). Our findings indicate that c-ski mRNA is up regulated by PMA only in those cell lines which respond by differentiating along the megakaryocyte lineage. The extent of differentiation and the observed increase in c-ski mRNA levels are positively correlated with the PMA concentration used to induce differentiation. Experiments in which CHRF-288-11 cells were treated with the protein kinase C (PKC) activator bryostatin 1 indicate that c-ski mRNA induction is not a general effect of PKC activation. The results strongly suggest that c-ski expression is correlated with megakaryocyte maturation.
The synthesis of some pyrido[1,4] benzoxazepines and a dipyrido[1,4] oxazepine (1978)

Abstract Synthetic routes to pyrido[2,3‐ b ]‐, pyrido[4,3‐ b ]‐, pyrido[3,2‐ f ] [1,4]benzoxazepines and dipyrido[2,3‐ b :2,3‐ f ] [1,4]oxazepine are described. The applicability of one of the methods to dibenz[ b,f ] [1,4]oxazepine synthesis is discussed.
Development of Resistance to MOPC-315 Plasmacytoma After Intralesional and Intraperitoneal Melphalan Therapy of Tumor-Bearing BALB/c Mice. II. Enhancement of In Vitro Cell-Mediated Cytotoxicity by Combined Chemotherapy-Immunotherapy<xref ref-type="fn" rid="FN2">2</xref> (1985)

As previously reported, tumor-bearing BALB/c mice can be cured by split-course melphalan therapy, with 40-60% of the treated animals developing resistance to subsequent challenge with viable MOPC-315. The present study deals with the identification of effector-cytotoxic cells that may be developed as a result of chemotherapy-induced tumor regression and their possible potentiation by active, specific immunization with melphalan- and glutaraldehyde-treated MOPC-315 plasmacytoma cells. The cytotoxic potential of spleen-derived lymphocytes in treated animals could be demonstrated only after in vitro sensitization against mitomycin-treated MOPC-315 cells. Lymphocyte-mediated cytotoxicity, as measured against syngeneic 51Cr-labeled MOPC-315, could be detected in melphalan-cured animals and was significantly enhanced by active immunization as compared to the cytotoxicity seen in normal and tumor-bearing mice. With the use of M109 syngeneic, unrelated tumor cells as control targets in the assay, no cytotoxicity was detected. Macrophage cytotoxicity was not significantly enhanced in any of the treatment groups described, with these assays performed 6-8 weeks following treatment and cure. When in vitro killing of MOPC-315 targets was tested with the use of peritoneal macrophages harvested shortly following cure of ascitic tumor by ip injected melphalan, the cytotoxic response was significantly enhanced. In conclusion, following chemotherapy-mediated cure of established MOPC-315 tumors, splenic lymphocytes exhibited enhanced antitumor cytotoxicity, which was further augmented by active immunization. Macrophage activation, as measured by direct cytotoxicity against MOPC-315 targets, was found to occur locally and early following the event of melphalan-induced tumor regression.