gebhart/patrepeval huggingface dataset:
Sensor Fusion for Predicting Vehicles' Path for Collision Avoidance Systems (2007)

Path prediction is the only way that an active safety system can predict a driver's intention. In this paper, a model-based description of the traffic environment is presented - both vehicles and infrastructure - in order to provide, in real time, sufficient information for an accurate prediction of the ego-vehicle's path. The proposed approach is a hierarchical-structured algorithm that fuses traffic environment data with car dynamics in order to accurately predict the trajectory of the ego-vehicle, allowing the active safety system to inform, warn the driver, or intervene when critical situations occur. The algorithms are tested with real data, under normal conditions, for collision warning (CW) and vision-enhancement applications. The results clearly show that this approach allows a dynamic situation and threat assessment and can enhance the capabilities of adaptive cruise control and CW functions by reducing the false alarm rate.
Efficient Power Management Scheme Considering Inter-User QoS in Wireless LAN (2006)

In wireless LAN, power saving is the essential issue to the node since the node has the limited battery. Hence, the nodes can use the Power Saving (PS) mode unless transmitting or receiving packet exists for the certain period. For the PS node to receive the buffered packet in Access Point (AP), the PS nodes periodically check the Traffic Indication Map (TIM) field in the beacon frame that contains the information about buffered packet. If the buffered packet exists, they must transmit the PS. POLL to the AP. The AP transmits the buffered packet to the node that succeeds to transmit the PS_POLL. However, when the node transmits the PS-POLL, the transmission order is determined without any priority. Therefore, we propose the efficient power management scheme to support inter-user QoS and reduce the power consumption in wireless LAN. In the proposed scheme, the node with high priority transmits PS_ POLL earlier than that with low priority, so the node with high priority receives the buffered packet faster than that with low priority, and reduces the power consumption by converting the mode from Active Mode (AM) to Power Saving (PS) for remaining beacon interval (BI). Through the analysis and simulation, we show that the proposed scheme reduces power consumption and guarantees inter-user QoS compared to conventional scheme.
Fabrication of All-Inorganic Nanocrystal Solids through Matrix Encapsulation of Nanocrystal Arrays (2011)

A general strategy for low-temperature processing of colloidal nanocrystals into all-inorganic films is reported. The present methodology goes beyond the traditional ligand-interlinking scheme and relies on encapsulation of morphologically defined nanocrystal arrays into a matrix of a wide-band gap semiconductor, which preserves optoelectronic properties of individual nanoparticles while rendering the nanocrystal film photoconductive. Fabricated solids exhibit excellent thermal stability, which is attributed to the heteroepitaxial structure of nanocrystal-matrix interfaces, and show compelling light-harvesting performance in prototype solar cells.
Correction: Ectopic Expression of Homeobox Gene NKX2-1 in Diffuse Large B-Cell Lymphoma Is Mediated by Aberrant Chromatin Modifications (2013)

Homeobox genes encode transcription factors ubiquitously involved in basic developmental processes, deregulation of which promotes cell transformation in multiple cancers including hematopoietic malignancies. In particular, NKL-family homeobox genes TLX1, TLX3 and NKX2-5 are ectopically activated by chromosomal rearrangements in T-cell neoplasias.
Hierarchical Associative Memory Based on Oscillatory Neural Network (2013)

In this thesis we explore algorithms and develop architectures based on emerging nano-device technologies for cognitive computing tasks such as recognition, classification, and vision. In particular we focus on pattern matching in high dimensional vector spaces to address the nearest neighbor search problem. Recent progress in nanotechnology provides us novel nano-devices with special nonlinear response characteristics that fit cognitive tasks better than general purpose computing. We build an associative memory (AM) by weakly coupling nano-oscillators as an oscillatory neural network and design a hierarchical tree structure to organize groups of AM units. For hierarchical recognition, we first examine an architecture where image patterns are partitioned into different receptive fields and processed by individual AM units in lower levels, and then abstracted using sparse coding techniques for recognition at higher levels. A second tree structure model is developed as a more scalable AM architecture for large data sets. In this model, patterns are classified by hierarchical k-means clustering and organized in hierarchical clusters. Then the recognition process is done by comparison between the input patterns and centroids identified in the clustering process. The tree is explored in a "depth-only" manner until the closest image pattern is output. We also extend this search technique to incorporate a branch-and-bound algorithm. The models and corresponding algorithms are tested on two standard face recognition data-sets. We show that the depth-only hierarchical model is very data-set dependent and performs with 97% or 67% recognition when compared to a single large associative memory, while the branch and bound search increases time by only a factor of two compared to the depth-only search.
Identification of a Retinoic Acid-Inducible Element in the Murine PTH/PTHrP (Parathyroid Hormone/Parathyroid Hormone-Related Peptide) Receptor Gene (1999)

We have shown previously that the PTH/PTHrP (PTH-related peptide) receptor mRNA becomes expressed very early in murine embryogenesis, i.e. during the formation of extraembryonic endoderm. Retinoic Acid (RA) is a potent inducer of extraembryonic endoderm formation and PTH/PTHrP-receptor expression in embryonal carcinoma (EC) and embryonal stem (ES) cells. Using the P19 EC cell line, we have characterized promoter elements of the murine PTH/PTHrP-receptor gene that are involved in this RA-induced expression. The data show that RA-induced expression of the PTH/PTHrP-receptor gene is mediated by the downstream P2 promoter. Analysis of promoter reporter constructs in transiently transfected P19 cells treated with RA identified an enhancer region between nucleotides− 2714 and −2702 upstream of the P2 transcription start site that is involved in the RA effect. This region matches a consensus hormone response element consisting of a direct repeat with an interspacing of 1 bp (R-DR1). The R-DR1 efficiently binds retinoic acid receptor-α (RARα)-retinoid X receptor-α (RXRα) and chicken ovalbumin upstream promoter (COUP)-transcription factor I (TFI)-RXRα heterodimers and RXRα and COUP-TFI homodimers in a bandshift assay using extracts of transiently transfected COS-7 cells. RA differentiation of P19 EC cells strongly increases protein binding to the R-DR1 in a bandshift assay. This is caused by increased expression of RXR (α, β, or γ) and by the induction of expression of RARβ and COUP TFI/TFII, which bind to the R-DR1 as shown by supershifting antibodies. The presence of RXR (α, β, or γ) in the complexes binding to the R-DR1 suggests that RXR homodimers are involved in RA-induced expression of the PTH/PTHrP-receptor gene. The importance of the R-DR1 for RA-induced expression of PTH/PTHrP-receptor was shown by an inactivating mutation of the R-DR1, which severely impairs RA-induced expression of PTH/PTHrP-receptor promoter reporter constructs. Since this mutation does not completely abolish RA-induced expression of PTH/PTHrP-receptor promoter reporter constructs, sequences other than the R-DR1 might also be involved in the RA effect. Finally, we show that the RA-responsive promoter region is also able to induce expression of a reporter gene in extraembryonic endoderm of 7.5 day-old transgenic mouse embryos.
Isolated Amyloid-β(1–42) Protofibrils, But Not Isolated Fibrils, Are Robust Stimulators of Microglia (2012)

Senile plaques composed of amyloid-β protein (Aβ) are an unshakable feature of the Alzheimer's disease (AD) brain. Although there is significant debate on the role of the plaques in AD progression, there is little disagreement on their role in stimulating a robust inflammatory response within the context of the disease. Significant inflammatory markers such as activated microglia and cytokines are observed almost exclusively surrounding the plaques. However, recent evidence suggests that the plaque exterior may contain a measurable level of soluble Aβ aggregates. The observations that microglia activation in vivo is selectively stimulated by distinct Aβ deposits led us to examine what specific form of Aβ is the most effective proinflammatory mediator in vitro. We report here that soluble prefibrillar species of Aβ(1-42) were better than fibrils at inducing microglial tumor necrosis factor α (TNFα) production in either BV-2 and primary murine microglia. Reconstitution of Aβ(1-42) in NaOH followed by dilution into F-12 media and isolation with size exclusion chromatography (SEC) revealed classic curvilinear β-sheet protofibrils 100 nm in length. The protofibrils, but not monomers, markedly activated BV-2 microglia. Comparisons were also made between freshly isolated protofibrils and Aβ(1-42) fibrils prepared from SEC-purified monomer. Surprisingly, while isolated fibrils had a much higher level of thioflavin T fluorescence per mole, they were not effective at stimulating either primary or BV-2 murine microglia compared to protofibrils. Furthermore, SEC-isolated Aβ(1-40) protofibrils exhibited significantly less activity than concentration-matched Aβ(1-42). This report is the first to demonstrate microglial activation by SEC-purified protofibrils, and the overall findings indicate that small, soluble Aβ(1-42) protofibrils induce much greater microglial activation than mature insoluble fibrils.
Effect of Treatment by Gaseous Carbon Dioxide on the Colloidal Phase of Skim Milk (1996)

Treatment of milk by injection of CO2 and depressurization was studied for the effect on milk salts and on the buffering properties of skim milk in order to correlate them t o mineral balance. Injection of CO2 by pressure decreased the pH of milk. ARer depressurization, pH returned to its initial state. No changes were observed in the concentrations of inorganic P, Ca, or Mg in the aqueous phase, determined after ultracentrifugation, but the buffering curves of depressurized milk that had been treated with CO2 were different from those of the original milk. For the initial milk, two buffering peaks at pH 4.95 and 5.40 were observed instead of one, showing that the solubilization of CO2 induced the formation of a new salt system. When CO2 pressure increased, the buffering value at pH 4.95 decreased; solubilization occurred for the inorganic calcium phosphate and the Ca directly bound to caseins. The second buffering value at pH 5.40 increased as new salts were formed. Higher pressures shifted the pH of maximal buffering from pH 4.95 to 4.75 and from pH 5.40 to 5.05. The CO2 had a reversible effect on pH and an irreversible effect on inorganic colloidal calcium phosphate, which was changed into other salt forms.
Resolution of Praziquantel (2011)

Both resolution procedures identified show promise for the large-scale, economically viable production of praziquantel as a single enantiomer for a low price. Additionally, they may be employed by laboratories for the production of smaller amounts of enantiopure drug for research purposes that should be useful in, for example, elucidation of the drug's mechanism of action.
Influence of the preparation procedure and chitosan type on physicochemical properties and release behavior of alginate–chitosan microparticles (2009)

This study showed that the latter formulation is eligible for further modifications aimed at improving the regularity of phenytoin absorption.
Integrated IP-Optical Networks. Demonstration of DWDM Router-to-Router IP Transport Over 574km SMF Fiber Link Using 11.1Gbit/s OTN Pluggable Interface with Integrated G.709 and FEC (2008)

We identify the key requirements for an open system approach to integrated IP over DWDM optical transport. Using, for the first time, DWDM XENPAK interfaces with integrated G.709 framing we demonstrate error-free connectivity of core IP routers across a 574 km amplified link with end-to-end G.709 FEC and OAM functions.
Undersampled Hyperspectral Image Reconstruction Based on Surfacelet Transform (2015)

Hyperspectral imaging is a crucial technique for military and environmental monitoring. However, limited equipment hardware resources severely affect the transmission and storage of a huge amount of data for hyperspectral images. This limitation has the potentials to be solved by compressive sensing (CS), which allows reconstructing images from undersampled measurements with low error. Sparsity and incoherence are two essential requirements for CS. In this paper, we introduce surfacelet, a directional multiresolution transform for 3D data, to sparsify the hyperspectral images. Besides, a Gram-Schmidt orthogonalization is used in CS random encoding matrix, two-dimensional and three-dimensional orthogonal CS random encoding matrixes and a patch-based CS encoding scheme are designed. The proposed surfacelet-based hyperspectral images reconstruction problem is solved by a fast iterative shrinkage-thresholding algorithm. Experiments demonstrate that reconstruction of spectral lines and spatial images is significantly improved using the proposed method than using conventional three-dimensional wavelets, and growing randomness of encoding matrix can further improve the quality of hyperspectral data. Patch-based CS encoding strategy can be used to deal with large data because data in different patches can be independently sampled.
erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines (2011)

IRS-1 can be recruited to IGF-IR and erbB3 in ER+ breast cancer cells, and this provides an adaptive resistance mechanism when these receptors are targeted individually. Consequently, cotargeting IGF-IR and either erbB3 or IRS-1 should prove to be a more effective strategy for the treatment of ER+ breast cancer.
Assessment of Acute Thermal Nociception in Laboratory Animals (2004)

Models of acute nociception using a thermal stimulus are widely employed as screening methods for nociceptive properties of new drug compounds. In this chapter, detailed descriptions for conducting of two of the most commonly used models; the hot plate test and the "Hargreaves test," are described. These models are applicable to both rats and mice and have the advantage of allowing repeated and multiple testing using a single animal because the stimulus is transitory and produces no tissue damage. Additionally, a modification of these models using a skin-twitch reflex that is applicable to large laboratory animals such a dogs or sheep is described. Guidance concerning potential confounding variable are discussed, as are tips for reducing variably among testing sessions.
Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of <i>N</i>-Aryl Cinnamides (2004)

The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role in regulating the function of sensory nerves. A growing body of evidence demonstrates the therapeutic potential of TRPV1 modulators, particularly in the management of pain. As a result of our screening efforts, we identified (E)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks the capsaicin-induced and pH-induced uptake of (45)Ca(2+) in TRPV1-expressing Chinese hamster ovary cells with IC(50) values of 17 +/- 5 and 150 +/- 80 nM, respectively. In this report, we describe the synthesis and structure-activity relationship of a series of N-aryl cinnamides, the most potent of which (49a and 49b) exhibit good oral bioavailability in rats (F(oral) = 39% and 17%, respectively).
Analysis of thermal characteristics of alternative mold materials for resin transfer molding (1992)

Resin transfer molding (RTM) characteristics of low mold filling pressure and low mild clamping force have given the opportunity to explore alternative RTM mold materials and tool designs. Thermally activated resins used in RTM dictate the requirement for proper heat management and temperature control. This work evaluates the thermal characteristics of five different mold materials for resin transfer molding. These include 1018 steel, C95400 aluminum bronze, 6061 aluminum, C18200 chrome copper and aluminum filled, epoxy/fiberglass composite molds. The tools and mold cavities were instrumented with thermocouples such that temperature differences could be measured in the thickness and lengthwise directions. Molded composite specimens were evaluated for residual reactivity and tensile strength. Additionally, the influence of mold temperature control point was investigated.
Cholesterol Biosynthesis Inhibitory Component from Zingiber officinale ROSCOE. (1993)

We previously reported on the isolation and identification of (E)-8 beta,17-epoxylabd-12-ene-15,16-dial (ZT) from ginger (rhizome of Zingiber officinale Roscoe, Zingiberaceae). In this paper, the pharmacological effects of ZT are reported. The experimental mouse hypercholesterolemia induced by Triton WR-1339 was treated after oral administration of ZT. In homogenated rat liver with ZT, cholesterol biosynthesis was decreased. In addition, the same activity was observed in the homogenated rat liver which was resected after the oral administration of ZT. According to the results of general pharmacological screening, no remarkable activity of ZT was observed except for an inhibitory effect on the cholesterol biosynthesis.
Distinct Cyclin D Genes Show Mitotic Accumulation or Constant Levels of Transcripts in Tobacco Bright Yellow-2 Cells1 (1999)

The commitment of eukaryotic cells to division normally occurs during the G1 phase of the cell cycle. In mammals D-type cyclins regulate the progression of cells through G1 and therefore are important for both proliferative and developmental controls. Plant CycDs (D-type cyclin homologs) have been identified, but their precise function during the plant cell cycle is unknown. We have isolated three tobacco (Nicotiana tabacum) CycD cyclin cDNAs: two belong to the CycD3 class (Nicta;CycD3;1 and Nicta;CycD3;2) and the third to the CycD2 class (Nicta;CycD2;1). To uncouple their cell-cycle regulation from developmental control, we have used the highly synchronizable tobacco cultivar Bright Yellow-2 in a cell-suspension culture to characterize changes in CycD transcript levels during the cell cycle. In cells re-entering the cell cycle from stationary phase, CycD3;2 was induced in G1 but subsequently remained at a constant level in synchronous cells. This expression pattern is consistent with a role for CycD3;2, similar to mammalian D-type cyclins. In contrast, CycD2;1 and CycD3;1 transcripts accumulated during mitosis in synchronous cells, a pattern of expression not normally associated with D-type cyclins. This could suggest a novel role for plant D-type cyclins during mitosis.
Learning hierarchical motif embeddings for protein engineering (2017)

Thesis: S.M., Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2017.
Synthesis and characterization of branched fullerene-terminated poly(ethylene glycol)s (2014)

Direct transesterification of phenyl-C<sub>61</sub>-butyric acid methyl ester with polyethylene glycols produces a range of multiple fullerene species. The use of a monodispersed PEG core allows isolation of a pure fully substituted product.
Cloud-based Performance Testing of Network Management Systems (2009)

Network Management Systems are often challenged by the need to manage networks comprised of a very large number of elements. Effective testing of performance, capacity and stability of these management systems often requires significant and, at times, cost-prohibitive investment in equipment and computing resources. This paper presents a method which leverages commercial cloud computing services for conducting large-scale tests of Network Management Systems. This method involves instantiation of large numbers of virtual network elements via the cloud computing infrastructure. After the network of virtual elements is up, it can be used for performance testing of the Network Management System. Considerations for evaluating, planning and implementing this method are discussed. Finally, a case study demonstrating the application and effectiveness of this method is presented.
Fusion of influenza virus with cardiolipin liposomes at low pH: mass action analysis of kinetics and extent (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFusion of influenza virus with cardiolipin liposomes at low pH: mass action analysis of kinetics and extentS. Nir, T. Stegmann, and J. WilschutCite this: Biochemistry 1986, 25, 1, 257–266Publication Date (Print):January 14, 1986Publication History Published online1 May 2002Published inissue 14 January 1986https://pubs.acs.org/doi/10.1021/bi00349a036https://doi.org/10.1021/bi00349a036research-articleACS PublicationsRequest reuse permissionsArticle Views144Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparison of Adeno-Associated Virus Serotypes and Delivery Methods for Cardiac Gene Transfer (2012)

Cardiac gene transfer is a potentially useful strategy for cardiovascular diseases. The adeno-associated virus (AAV) is a common vector to obtain transgene expression in the heart. Initial studies conducted in rodents used indirect intracoronary delivery for cardiac gene transfer. More recently AAV vectors with so-called cardiac tropism have enabled significant cardiac transgene expression following intravenous injection. However, a direct comparison of intravenous versus intracoronary delivery with rigorous quantification of cardiac transgene expression has not been conducted. In the present study we tested the hypothesis that intracoronary AAV delivery would be superior to intravenous delivery vis-à-vis cardiac transgene expression. We compared intravenous and intracoronary delivery of AAV5, AAV6, and AAV9 (5×10(11) genome copies per mouse). Using enhanced green fluorescent protein as a reporter, we quantified transgene expression by fluorescence intensity and Western blotting. Quantitative polymerase chain reaction (PCR) was also performed to assess vector DNA copies, employing primers against common sequences on AAV5, AAV6, and AAV9. Intracoronary delivery resulted in 2.6- to 28-fold higher transgene protein expression in the heart 3 weeks after AAV injection compared to intravenous delivery depending on AAV serotype. The highest level of cardiac gene expression was achieved following intracoronary delivery of AAV9. Intracoronary delivery of AAV9 is a preferred method for cardiac gene transfer.