gebhart/patrepeval huggingface dataset:
Angiotensin II Receptors and Aldosterone Production in Rat Adrenal Glomerulosa Cells (1978)

Specific receptors for angiotensin II (A II) were demonstrated in membrane fractions and collagenase-dispersed cells from the zona glomerulosa of the rat adrenal gland. The equilibrium association constant (Ka) of the A II binding sites was similar in particulate fractions (2.0 +/- 0.4 (SE) X 10(9) M-1) and intact glomerulosa cells (1.8 +/- 0.3 X 10(9) M-1). Specific binding of [125I]iodo-A II was enhanced by increasing sodium concentration, and in the presence of dithiothreitol, EDTA, and EGTA. Plasma membrane fractions prepared by density gradient centrifugation showed increased binding of [125I]iodo-A II, and were correspondingly enriched in adenylate cyclase and sodium-potassium-dependent ATPase. Steroid production by collagenase-dispersed adrenal glomerulosa cells was highly responsive to A II and ACTH. Significant increases in aldosterone and corticosterone production were elicited by A II concentrations as low as 3 X 10(-11) M, equivalent to normal blood levels of A II in rats (5 X 10(-11) M). The maximum increase in aldosterone production, of 6--7 times the basal value, was obtained at 10(-9) M A II. Dispersed capsular cells were also highly sensitive to ACTH, responding to concentrations down to 3 X 10(-12) M with increased aldosterone production, reaching a maximum aldosterone response of 20-fold above the basal value. The magnitudes of the aldosterone and corticosterone responses to A II in capsular and fasciculata-reticularis cells were commensurate with the distribution of A II receptors, which were 11-fold more concentrated in capsular cells. The ability of A II to evoke aldosterone production at physiological concentrations, and the correspondence between A II binding and steroidogenesis in capsular cells, demonstrate the functional importance of A II receptor sites in the zona glomerulosa of the rat adrenal cortex.
Synthesis and Properties of Oligo-<i>para</i>-phenylene Substituted Porphyrins (1997)

Abstract A series of oligo-para-phenylene (OPP) substituted new porphyrins was prepared by the combinations of aryl coupling reactions and Lindsey’s pyrrole condensation reactions. Low field shifts of OPP protons in 1H-NMR spectra became larger when the protons locate closer to the center of the molecule.
C++ and the OOP Paradigm (1992)

The object-oriented paradigm classes inheritance polymorphism multiple inheritance the actor model object-oriented databases what's new in OOP.
Efficient Computational Algorithms for Docking and for Generating and Matching a Library of Functional Epitopes II. Computer Vision-Based Techniques for the Generation and Utilization of Functional Epitopes (1999)

This is the second review in a two-part series. In the first review (1) we described the computational complexity involved in the docking of a ligand onto a receptor surface. In particular, we focused on efficient algorithms designed to handle this computational task. Such a procedure results in a large number of potential, geometrically feasible solutions. The difficulty is to pinpoint which of these is the more likely candidate. While there exists a number of approaches to rank these solutions according to different criteria, such as the size of the interface or some approximation of their binding energetics, none of the existing methods has been shown to be consistently successful in this endeavor. If the binding site is unknown a priori, the magnitude of the task is awesome. Here we propose one way of addressing this problem, i.e., via derivation and utilization of binding epitopes. If a library of such epitopes is available, particularly for a large number of protein families, it may be used to predict more likely binding sites for a given ligand. We describe an efficient, computer-vision based method to construct binding epitopes focusing on two ways through which such a library can be generated, (i) molecular surface-based, or (ii) residue-based. Alternatively, the two can be combined. We further describe how such a library may be used efficiently in the matching/docking procedure.
CHAMBER MUSIC (1970)

CHAMBER MUSIC Get access Alun Hoddinott, Divertimenti for eight instruments, Op. 58. Miniature score. ( Oxford University Press, 1969, 16s.) Alan Rawsthorne, Quintet for piano and strings. Score. ( Oxford University Press, 1969, £1 10s.) Claudio Spies, LXXXV: Eights and Fives for strings and clarinets. Score and parts. ( Boosey & Hawkens, New York, 1969, £2 2s.) J. A. C. J. A. C. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume LI, Issue 3, July 1970, Pages 333-b–334, https://doi.org/10.1093/ml/LI.3.333-b Published: 01 July 1970
Imaging of coronary atherosclerosis by computed tomography (2010)

Modern computed tomography (CT) systems afford sufficient spatial and temporal resolution for imaging of the heart and coronary arteries. The detection of coronary artery calcium (CAC) is relatively straightforward and it is applied to detect and quantify subclinical coronary atherosclerosis even in asymptomatic individuals. A large body of evidence has accumulated that uniformly attests to a high predictive value of CAC for future cardiac events. More complex data acquisition protocols, which require higher spatial and temporal resolution, specific patient preparation, and the intravenous injection of contrast agent, allow to perform coronary CT angiography (CTA). With CTA, the presence of luminal stenoses and, given sufficient image quality, calcified as well as non-calcified atherosclerotic plaque can be visualized. Initial studies have shown that certain plaque characteristics, such as positive remodelling or very low CT attenuation, are associated with plaque vulnerability. So far, the available clinical data are not sufficient to draw specific conclusions as to the risk-benefit ratio of contrast-enhanced coronary CTA for risk prediction, especially for asymptomatic individuals. Hence, CTA is currently not recommended for risk stratification purposes. However, the technology of coronary CTA continues to evolve at a rapid pace and clinical applications for plaque imaging and characterization may become possible in the future.
Long‐term Results of Bladder Transection for Urge Incontinence (1983)

One hundred and four patients with urge incontinence associated with detrusor instability who had failed to respond to standard conservative treatment were treated by a modified bladder transection procedure. Initially 74% were symptomatically cured, 14% were improved and 12% were failures. At 2 to 5 years after operation these results were 65%, 19% and 16% respectively. There was no significant morbidity and no mortality. Bladder transection is still a useful method of treatment for the refractory patient with detrusor instability, although improvements in conservative treatment have reduced the need for it.
The Distribution and Transport of Alpha Activity in Tin (2012)

The presence of alpha emitters in packaging materials pose an increased risk to device reliability as device size decreases and flip chip and 3-D packaging technology becomes more widespread. Particularly troubling is the observation that alpha emission increases over time in some reported instances. Several experiments were conducted to examine alpha flux behavior in tin materials and determine the cause for the temporal alpha emissivity increase. The experiments determined the distribution of the alpha emitters within the material volume, and a mechanism based on microsegregation is presented to explain the non uniform distribution. Data describing differential isotope distribution within tin are also presented, providing confirmation of 210Po transport within a solid tin matrix. The effects of microsegregation and 210Po migration on alpha emissivity over time will be discussed. Potential impacts from these mechanisms on alpha emissivity in packaging applications will also be presented.
Low <i>BIN3</i> Expression is an Independent Predictor of Unfavorable Survival in Patients With Primary Colorectal Cancer (2017)

This study aimed to explore the mechanisms of bridging integrator-3 dysregulation, its prognostic value, and related signaling pathways in colorectal cancer . Bioinformatic analysis was performed based on the data from The Cancer Genome Atlas–colorectal cancer and Human Protein Atlas. Colorectal cancer cell lines, LoVo and HT29 cells, were used as in vitro cell model to assess the effect of demethylation on bridging integrator-3 expression. Results showed that bridging integrator-3 was downregulated in colorectal cancer tissues compared to normal colon and rectum tissues. Heatmap of bridging integrator-3 messenger RNA expression, exon expression, and DNA methylation indicated a negative correlation between bridging integrator-3 expression and methylation of some CpG sites within the coding sequence. Demethylation treatment significantly increased bridging integrator-3 expression in LoVo and HT29 cells. Low bridging integrator-3 messenger RNA and exon expression were associated with significantly worse overall survival ( P = .015 and .013, respectively). Multivariate analysis confirmed that low bridging integrator-3 messenger RNA expression was an independent prognostic factor of unfavorable overall survival (Hazard Ratio (HR) = 1.596, 95% confidence interval: 1.024-2.486; P = .039). High bridging integrator-3 DNA methylation was also associated with significantly worse overall survival ( P = .013). Kyoto Encyclopedia of Genes and Genomes analysis indicated that the genes correlated with bridging integrator-3 (absolute Pearson r ≥ 0.3, n = 121) were enriched in sphingolipid signaling pathway, natural killer cell-mediated cytotoxicity, p53 signaling pathway, and apoptosis. Based on these findings, we infer that DNA hypermethylation might be an important mechanism of suppressed bridging integrator-3 expression in colorectal cancer . Its low expression is an independent predictor of unfavorable survival in patients with primary colorectal cancer . Bridging integrator-3 might act as a tumor suppressor via modulating natural killer cell-mediated cytotoxicity, p53 signaling pathway, and apoptosis.
ECG-based indices of physical activity (2003)

Inter-subject comparisons of heart rate variability (HRV) require that physical activity levels be matched between subjects, to minimize the confounding effects of intrasubject variability in HRV measurements. The current study investigated methods for finding periods of minimum physical activity based on the electrocardiogram (ECG) alone. The author describes an activity index based on the heart rate, total power of the observed heart rate signal, and a heart rate stationary index, and presents an algorithm for locating periods of minimum activity by tracking this activity index. The algorithm was tested using a set of 35 ECG recordings for which an independent activity indicator was available. The algorithm consistently selected periods of minimum activity in agreement with the independent activity indicator. No discrepancies were noted in any of the 35 cases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Novel VIP Responsive Gene: Activity Dependent Neuroprotective Protein (2000)

Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolar-acting NAP and through putative interaction with other macromolecules.
Optimal control of a multi-product inventory system with substitution (2003)

We study a single-period, multi-product inventory model that allows substitution among the products. The main decision is the replenishment (order) quantity for each product at the beginning of the period, before demands are realized. This decision, however, has to take into account the substitution rule, which will be carried out, also in an optimal fashion, at the end of the period when demands are realized. We first derive an optimal substitution rule, and show that under this rule, the objective function is both concave and submodular in the order quantities-decision variables. Hence, the optimal replenishment decision can be effectively generated by solving a concave program.
The<i> KIR</i> gene family: life in the fast lane of evolution (2004)

A hallmark of human NK cells is the expression of HLA class I-specific killer-cell immunoglobulin-like receptors (KIR). An interesting facet of the KIR family is the unusual variability of the respective gene cluster, which is changing shape at an astonishing evolutionary pace. Not only do KIR genes come in different allelic variants, but the KIR locus has also gone through drastic contractions and expansions in recent evolutionary history, resulting in a wide variety of KIR haplotypes. A new study now reveals how an originally nonfunctional KIR pseudogene, KIR3DP1, is brought back to life in certain individuals via non-reciprocal recombination between two different KIR haplotypes. This Commentary outlines how the unique architecture of the KIR locus facilitates the generation of new KIR haplotypes and discusses the functional relevance of it.
How I wasted too long finding a concentration inequality for sums of geometric variables (2011)

I wanted a concentration inequality for sums of iid geometric random variables. This took way too long.
Acid rain, promoting the accumulation of CO{sub 2} in surface waters?! (1996)

ACS patients with a history of HT and DM had a higher age-adjusted, long-term mortality risk than ACS patients without such a history. DM appeared to be more strongly associated with mortality than HT, but its combination was additive.
Thrombus imaging with indium-111 and iodine-131-labeled fibrin-specific monoclonal antibody and its F(ab')2 and Fab fragments. (1988)

We have previously reported successful imaging of fresh (2-4 hr old) and aged (1-5 days old) canine thrombi with 131I-labeled intact monoclonal antibody (MAb) specific for fibrin. We now report thrombus imaging with 131I-labeled F(ab')2 and Fab and 111In-labeled intact MAb, F(ab')2, and Fab. Indium-111-labeled F(ab')2 proved to be the best imaging agent due to less nonspecific binding in the liver than whole IgG. Image quality was improved by the higher administered dose permissible with 111In and its better physical characteristics for imaging, compared to 131I. Immunofluorescence of fresh human histologic sections showed intact MAb and F(ab')2 binding to thrombi, pulmonary emboli, and atherosclerotic plaques, strengthening the feasibility of clinical thrombus imaging.
<b>The Mean Ventricular Fibrillation Cycle Length:</b> A Potentially Useful Parameter for Programming Implantable Cardioverter Defibrillators (1998)

In programming the implantable cardioverter defibrillator (ICD), the ventricular tachycardia (VT) detection cycle length (CL) is based on the CL of the documented tachycardia but the ventricular fibrillation (VF) detection CL is set arbitrarily. Appropriate programming of VF detection may not only reduce the incidence of inappropriate ICD shocks for non-VF rhythms but can also avoid the fatal underdetection of VF. The mean VFCL may provide a useful parameter for optimal ICD programming for VF detection if it is reproducible. This study examined the intrapatient reproducibility and interpatient variation of the mean VFCL in 30 ICD patients (25 men and 5 women, mean age 63 +/- 13 years). A total of 210 VF episodes (7 +/- 4 per patient, range 3-17) induced by T-wave shocks (166) or AC (44) at the ICD implant (30 patients) and the predischarge test (12 of 30 patients) were analyzed. The mean VFCL was calculated from the stored V-V intervals in the ICDs. Although the mean VFCL varied significantly from 171 +/- 6 to 263 +/- 11 ms (P < 0.01) among different patients, it was reproducible among different VF episodes in an individual patient (maximal variation 4-50 ms, P > 0.05). The mean VFCL was not significantly different between patients with and without antiarrhythmic drugs (210 +/- 32 vs 210 +/- 23 ms, P > 0.05) and was correlated with the ventricular effective refractory period (r = 0.5, P < 0.05). The mean VFCL varies greatly among different patients but remains reproducible in an individual patient, suggesting that the mean VFCL may serve as a reference for ICD programming of VF detection.
Synthesis of tryptanthrin and deoxyvasicinone by a regioselective lithiation-intramolecular electrophilic reaction approach (2008)

An efficient synthesis of the 4(3H)-quinazolinone-based alkaloids, tryptanthrin and deoxyvasicinone has been achieved in good overall yields by using the strategy of regioselective lithiation-intramolecular electrophilic reaction as a key-step. Both the molecules have been synthesized in just two-steps from readily available starting materials.
Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples (1981)

A method to detect chemically stable lesions in DNA has been developed using Exonuclease III, a double strand specific nuclease, to digest 5′-end labeled DNA. The products, when analyzed on high resolution DNA sequencing gels, reveal the sites of DNA modification. Cyclobutane pyrimidine dimers induced by UV irradiation can be localized by comparison of the fragments produced by Exonuclease III digestion with fragments obtained after digestion of the DNA with UV specific endonuclease. The experiments demonstrate that Exonuclease III stops one base away from the cyclobutane pyrimidine dimers. Similar experiments with cis- and trans-dichlorodiammine-platinum (II) showed that modifications of DNA by these agents also impede Exonuclease III digestion. In general the same stop sites were found for cis-and trans-platinum adducts. They occur at sites of guanine bases. Additional stop sites were found for cis-platinum at sites of adjacent guanine bases. These results are in agreement with the model that cis-platinum forms intrastrand guanine-guanine dimers, whereas trans-platinum does not.
Drill hole position in endoscopic anterior cruciate ligament reconstruction (1998)

In 24 cadaver knees the anterior cruciate ligament (ACL) was replaced by a bone-tendon-bone patellar tendon autograft in an endoscopic technique. This was carried out during an advanced arthroscopy course after intensive instruction and practice on a plastic model. When the knees were opened and evaluated according to the recent orthopaedic literature, only four good results with correct tunnels and a non-impinging graft were found. In 12 knees the femoral tunnel was too far anterior (10) or had broken through the posterior femoral cortex (2). In 6 knees the tibial tunnel was too far anterior (2) or too far posterior (4). The notchplasty was insufficient in 6 knees. We conclude that endoscopic ACL reconstruction cannot be mastered after attending a course alone. Expert help is necessary during the first clinical cases.
Comparison of Thermodynamic and Kinetic Aspects of Oxidative Addition of PhE−EPh (E = S, Se, Te) to Mo(CO)<sub>3</sub>(PR<sub>3</sub>)<sub>2</sub>, W(CO)<sub>3</sub>(PR<sub>3</sub>)<sub>2</sub>, and Mo(N[<sup>t</sup>Bu]Ar)<sub>3</sub> Complexes. The Role of Oxidation State and Ancillary Ligands in Metal Complex Induced Chalcogenyl Radical Generation (2006)

Enthalpies of oxidative addition of PhE-EPh (E = S, Se, Te) to the M(0) complexes M(PiPr3)2(CO)3 (M = Mo, W) to form stable complexes M(*EPh)(PiPr3)2(CO)3 are reported and compared to analogous data for addition to the Mo(III) complexes Mo(N[tBu]Ar)3 (Ar = 3,5-C6H3Me2) to form diamagnetic Mo(IV) phenyl chalcogenide complexes Mo(N[tBu]Ar)3(EPh). Reactions are increasingly exothermic based on metal complex, Mo(PiPr3)2(CO)3 < W(PiPr3)2(CO)3 < Mo(N[tBu]Ar)3, and in terms of chalcogenide, PhTe-TePh < PhSe-SePh < PhS-SPh. These data are used to calculate LnM-EPh bond strengths, which are used to estimate the energetics of production of a free *EPh radical when a dichalcogenide interacts with a specific metal complex. To test these data, reactions of Mo(N[tBu]Ar)3 and Mo(PiPr3)2(CO)3 with PhSe-SePh were studied by stopped-flow kinetics. First- and second-order dependence on metal ion concentration was determined for these two complexes, respectively, in keeping with predictions based on thermochemical data. ESR data are reported for the full set of bound chalcogenyl radical complexes (PhE*)M(PiPr3)2(CO)3; g values increase on going from S to Se, to Te, and from Mo to W. Calculations of electron densities of the SOMO show increasing electron density on the chalcogen atom on going from S to Se to Te. The crystal structure of W(*TePh)(PiPr3)2(CO)3 is reported.
Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit. (2013)

We report on an audit of 138 ME/CFS patients who attended a private practice and took the ATP Profile biomedical test. The results revealed that all of these patients had measureable mitochondrial dysfunction. A basic treatment regime, based on 1) eating the evolutionary correct stone-age diet, 2) ensuring optimum hours of good quality sleep, 3) taking a standard package of nutritional supplements, and 4) getting the right balance between work and rest, was recommended for all patients. Additions to the basic regime were tailored for each patient according to the results of the ATP Profile and additional nutritional tests and clues from the clinical history. Mitochondrial function is typically impaired in two ways: substrate or co-factor deficiency, and inhibition by chemicals, exogenous or endogenous. For the former, additional nutrients are recommended where there is a deficiency, and for the latter, improvement of anti-oxidant status and selective chelation therapy or far-infrared saunas are appropriate. We show case histories of nine patients who have taken the ATP Profile on three or four occasions, and a before-and-after treatment summary of the 34 patients who have had at least two ATP Profile tests separated by some months. Finally, we summarize the results for the 30 patients who followed all aspects of the treatment regime and compare them with the 4 patients who were lax on two or more aspects of the treatment regime. All patients who followed the treatment regime improved in mitochondrial function by on average a factor of 4.
Environmental and system effects on source localization in shallow water by the matched-field processing of a vertical array (1989)

This paper presents simulated and experimental results on source localization in shallow water by the matched-field processing of a vertical array. Range-depth ambiguity surfaces are obtained by the spatial correlation of the incident field (modeled or real) with a modeled replica of that field. All modeled fields are generated by the Centre’s normal-mode program. The simulated results indicate that a high-quality ambiguity surface can be obtained provided that the incident field is formed by a significant number of contributing modes, and that the array spans a large fraction of the water column. Changes in the acoustic environment that reduce the effective number of modes result in a degraded surface. The effect of mismatches between the ‘‘true’’ environmental parameters and those used to compute the replica field is also investigated. Errors in the bottom parameters do not severely effect the results, but small mismatches in sound-speed profile or water depth can degrade the result significantly. Examples of localizations obtained with real data from a Mediterranean site are presented, for source ranges up to 19 km from a vertical array that spanned half the water depth. Successful localizations were obtainable, though high sidelobes were also present.