gebhart/patrepeval huggingface dataset:
Proteolysis of the Human Platelet and Endothelial Cell Thrombin Receptor by Neutrophil-derived Cathepsin G (1995)

Cathepsin G is a neutrophil-derived protease that has been shown to inhibit the effects of thrombin on some cells expressing thrombin receptors while acting as an agonist on others. The present studies examine whether cleavage of the thrombin receptor by cathepsin G can account for these diverse effects. When added to cells that normally respond to thrombin, cathepsin G prevented a subsequent cytosolic Ca2+ increase caused by thrombin, but had no effect on responses to the thrombin receptor agonist peptide, SFLLRN. These effects were observed in cells in which cathepsin G had little or no agonist effect (human umbilical vein endothelial cells and HEL cells), as well as in cells in which cathepsin G acted as an agonist (platelets and CHRF-288 cells). Binding studies using monoclonal antibodies with defined epitopes within the first 60 residues of the thrombin receptor N-terminus showed that incubation of platelets and endothelial cells with cathepsin G abolished the binding of all of the antibodies, while thrombin abolished only the binding of antibodies whose epitopes were N-terminal to the known thrombin cleavage site between Arg41 and Ser42. Analysis of peptide proteolytic fragments identified three potential cleavage sites for cathepsin G: Arg41-Ser42, Phe43-Leu44, and Phe55-Trp56. Cleavage at Phe55-Trp56 would account for both the observed loss of all of the antibody binding sites and the inhibition of receptor activation by thrombin. Two approaches were used to determine whether a solitary cleavage at Arg41-Ser42 could result in receptor activation. In the first, HEL cells were exposed to cathepsin G or thrombin in the presence of an antibody whose epitope includes Phe55. The antibody inhibited responses to thrombin, but augmented the response to cathepsin G. In the second, COS-1 cells were transfected with variant thrombin receptors in which Phe55 and Trp56 were mutated to alanine. Transfected wild-type receptors responded to thrombin, but not cathepsin G, while the variant receptors responded to both proteases. These results 1) suggest that the ability of cathepsin G to inhibit responses to thrombin, but not SFLLRN, is due to cleavage of the receptor at Phe55-Trp56, deleting the tethered ligand domain, and 2) show that cathepsin G can activate thrombin receptors, but only if the cleavage site at Phe55-Trp56 is mutated or otherwise protected.(ABSTRACT TRUNCATED AT 400 WORDS)
Analyzing Group Interactions in Conversations: a Review (2006)

Multiparty face-to-face conversations in professional and social settings represent an emerging research domain for which automatic activity-based analysis is relevant for scientific and practical reasons. The activity patterns emerging from groups engaged in conversations are intrinsically multimodal and thus constitute interesting target problems for multistream and multisensor fusion techniques. In this paper, a summarized review of the literature on automatic analysis of group activities in face-to-face conversational settings is presented. A basic categorization of group activities is proposed based on their typical temporal scale, and existing works are then discussed for various types of activities and trends including addressing, turn taking, interest, and dominance
Patterns of Speech Disorders in Schizophrenia and Mania (1994)

Formal thought disorder (FTD), defined as abnormal speech, has been associated with schizophrenia and likened to fluent aphasia. Whether FTD differentiates subtypes of schizophrenics and discriminates schizophrenics from other patients is unclear. We studied this issue by analyzing ratings of FTD of 170 schizophrenics and 62 manics. Eighty percent of emotionally blunted schizophrenics had FTD compared with 6.5% of manics. Factor analysis revealed verbiage disturbance and disorganized speech factors (44% of the variance). We assessed the discriminating ability of these factors, and compared these results to those from factors derived from Andreasen's positive/negative FTD construct, and to factors derived from speech and language diagnostic criteria for schizophrenia and mania in the proposed DSM-IV. Overall classifications were similar (91%, 91%, and 88%, respectively). We also found that FTD was related to emotional blunting, but not to other psychopathology.
Plasma Actuators for Bluff Body Flow Control (2006)

In this paper the results of flow control experiments utilizing single dielectric barrier discharge plasma actuators to control flow separation and unsteady vortex shedding from a circular cylinder in cross-flow are reported. This work is motivated by the need to reduce landing gear noise for commercial transport aircraft via an effective streamlining created by the actuators. The experiments are performed at ReD = 33,000. Using either steady or unsteady actuation, Karman shedding is totally eliminated, turbulence levels in the wake decrease significantly and near-field sound pressure levels are reduced by 13.3 dB. Unsteady actuation at an excitation frequency of StD = 1 is found to be most effective. The unsteady actuation also has the advantage that total suppression of shedding is achieved for a duty cycle of only 25%. cylinder diameter D Re = Reynolds number based on cylinder diameter D St = Strouhal number based on cylinder diameter 1 T = time period of unsteady actuation
Ten‐year follow‐up study of cortisol levels in aging holocaust survivors with and without PTSD (2007)

To investigate the longitudinal course of mean 24-hour urinary cortisol excretion in posttraumatic stress disorder (PTSD), the authors evaluated 24-hour cortisol excretion in 28 Holocaust survivors 10 years after obtaining an initial estimate. Cortisol levels increased in participants whose PTSD had remitted (n = 3) but declined in participants who developed PTSD (n = 3) or whose PTSD status did not change over time (PTSD+: n = 14, PTSD-: n = 8). Cortisol levels at Time 1 predicted diagnostic status change better than psychological variables, including exposure to traumatic events between assessments. The authors conclude that cortisol levels are affected by change in PTSD status and age.
Performance Evaluation of Closed-Loop Spatial Multiplexing Codebook Based on Indoor MIMO Channel Measurement (2012)

Closed-loop MIMO technique standardized in LTE can support different layer transmissions through precoding operation to match the channel multiplexing capability. However, the performance of the limited size codebook still needs to be evaluated in real channel environment for further insights. Based on the wideband MIMO channel measurement in a typical indoor scenario, capacity loss (CL) of the limited size codebook relative to perfect precoding is studied first in two extreme channel conditions. The results show that current codebook design for single layer transmission is nearly capacity lossless, and the CL will increase with the number of transmitted layers. Furthermore, the capacity improvement of better codebook selection criterions is very limited compared to CL. Then we define the maximum capacity boost achieved by frequency domain layer adaption (FDLA) and investigate its sensitivity to SNR and channel condition. To survey the effect of frequency domain channel variation on MIMO-OFDM system, we define a function to measure the fluctuation levels of the key channel metrics within a subband and reveal the inherent relationship between them. Finally, a capacity floor resulted as the feedback interval increases in frequency domain.
CALCIUM-FATTY ACID ABSORPTION IN TERM INFANTS FED HUMAN MILK AND PREPARED FORMULAS SIMULATING HUMAN MILK (1970)

In full-term infants 4 to 10 days of age fed human milk or formulas of higher fat and calcium content, the absorption and retention of nitrogen and phosphorus are equal. Higher fecal excretion of fat and calcium were observed. There is a correlation between calcium and palmitic and stearic acid in the stools. This correlation is found at both low and high levels of fecal calcium. It is not clear whether the reduced calcium absorption or the reduced fat absorption is the primary event.
Dysregulated angiogenesis in B-chronic lymphocytic leukemia: Morphologic, immunohistochemical, and flow cytometric evidence (2008)

CLL demonstrates enhanced angiogenesis, with increased MVD, upregulated VEGF and downregulated TSP-1. Upregulation of HIF-1a in all CLL cases suggests localized tissue hypoxia as an important stimulant of microvessel proliferation. The presence of VEGF receptors on CLL cells implies an autocrine effect for VEGF. Differences in MVD did not correlate with traditional genetic/immunophenotypic markers of aggressiveness.
Quantized Conductance in $\hbox{Ag/GeS}_{2}/\hbox{W}$ Conductive-Bridge Memory Cells (2012)

Ag/GeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /W conductive-bridge random access memory (CBRAM) cells are shown to program at room temperature to conductance levels near multiples of the fundamental conductance G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> = 2e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /h. This behavior is not accounted for in the traditional view that the conductance of a CBRAM cell is a continuous variable proportional to the maximum current allowed to flow during programming. For on -state resistances on the order of 1/G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> = 12.9 kΩ or less, quantization implies that the Ag “conductive bridge” typically contains a constriction, or even an extended chain, that can be as narrow as a single atom. Implications for device modeling and commercial applications are discussed.
Acute ultrastructural effects of the antitumor antibiotic carminomycin on nucleoli of rat tissues. (1979)

Male Sprague-Dawley rats were treated with carminomycin i.v. in doses ranging from 1 to 40 mg/kg. Within 1 hr after the administration of carminomycin, 20 mg/kg, nucleoli of cardiac and skeletal muscle cells were segregated, while nucleoli of liver parenchyma cells were unaffected. Three and one-half hr after drug administration, cardiac muscle nucleoli reverted to normal ultrastructure. However, some skeletal muscle cell nucleoli were still segregated. Following treatment with carminomycin, 10 mg/kg, no significant ultrastructural changes were observed. These results demonstrate that at sufficiently high doses carminomycin induces ultrastructural lesions in nucleoli of both cardiac and muscle cells. The dose of carminomycin required to produce nucleolar segregation in cardiac and skeletal muscle is 6 times greater than the dose of Adriamycin (3.5 mg/kg) required to induce equivalent alterations.
The Effects of Antihypertensive Agents on Atherosclerosis-Related Parameters of Human Aorta Intimal Cells (1998)

Four antihypertensive agents - amlodipine, verapamil, propranolol and perindoprilat - were studied in human cell cultures. Antiatherogenic activity was investigated using uninvolved human aortic smooth muscle intima cells and atherogenic serum obtained from patients with coronary atherosclerosis. Amlodipine and verapamil significantly inhibited serum-induced increases in cholesterol content, cell-proliferative activity and protein synthesis in the cultured cells. Propranolol increased all three parameters, while perindoprilat had no effects. In addition, amlodipine and verapamil significantly lowered the intracellular cholesterol content of smooth muscle cells derived from atherosclerotic plaque and inhibited cell proliferation and protein synthesis. Propranolol increased all of these parameters, while perindoprilat produced no effects. The antiatherogenic and antiatherosclerotic actions of verapamil and amlodipine were confirmed in an ex vivo model. These studies demonstrated a beneficial antiatherosclerotic effect of amlodipine that was greater than that of verapamil. Perindoprilat had a neutral effect on atherosclerotic parameters, while the action of propranolol appeared to be potentially detrimental.
Characterization of the Binding of the Fluorescent Dyes YO and YOYO to DNA by Polarized Light Spectroscopy (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of the Binding of the Fluorescent Dyes YO and YOYO to DNA by Polarized Light SpectroscopyAnette Larsson, Christina Carlsson, Mats Jonsson, and Bo AlbinssonCite this: J. Am. Chem. Soc. 1994, 116, 19, 8459–8465Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00098a004https://doi.org/10.1021/ja00098a004research-articleACS PublicationsRequest reuse permissionsArticle Views2408Altmetric-Citations258LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease (2010)

Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)-hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD.
Histopathological changes in the testes of prepubertal male rats after chronic administration of cocaine. (1997)

There were distinct histopathological changes noted after chronic administration of cocaine. These changes are characteristic of toxic effects on the testes, but the exact mechanism is not clear. Further studies are underway in our laboratory to delineate the exact mechanism of action by cocaine on the testes.
Photoelectron study of Yb/<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">C</mml:mi></mml:mrow><mml:mrow><mml:mn>60</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>bilayers and the Yb fullerides formed at the interfaces (1993)

Photoelectron measurements were obtained for Yb-${\mathrm{C}}_{60}$ and the results are compared to those reported for alkali-metal fullerides and Yb isolated in xenon or solid ${\mathrm{NH}}_{3}$. The valence photoelectron spectra for Yb deposited on ${\mathrm{C}}_{60}$ and ${\mathrm{C}}_{60}$ on Yb show changes in the Yb 4f peaks, and in the ${\mathrm{C}}_{60}$ valence states and a metal-induced state just above the Yb 4f bands. The position of this valence feature is near to that found for an analogous feature in the nonsuperconducting ${\mathrm{K}}_{6}$${\mathrm{C}}_{60}$ fulleride. Similar features also appear when Yb is solvated in condensed ammonia. The appearance and binding energy of the Yb 4f levels argue that the Yb is largely divalent but has a small trivalent component. A comparison of the data for Yb-${\mathrm{C}}_{60}$ with that for Yb clusters in xenon shows that the changes in the electronic state of the Yb are not those found for small Yb particles in a nonreactive matrix.
Emission microscopy in semiconductor failure (2002)

Emission microscopy is introduced as a new technique for semiconductor failure analysis. Very faint photo-emission is observed where various abnormal condition is arising. To find exact location of the failure site is a key to improve the design and production yield of the device. Emission microscope and it's application is described with practical analysis results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Responsabilité des parents du fait de leur enfant : la notion de cohabitation (2004)

International audience
Minimum Energy to Send $k$ Bits Through the Gaussian Channel With and Without Feedback (2011)

The minimum achievable energy per bit over memoryless Gaussian channels has been previously addressed in the limit when the number of information bits goes to infinity, in which case it is known that the availability of noiseless feedback does not lower the minimum energy per bit, which is -1.59 dB below the noise level. This paper analyzes the behavior of the minimum energy per bit for memoryless Gaussian channels as a function of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> , the number of information bits. It is demonstrated that in this nonasymptotic regime, noiseless feedback leads to significantly better energy efficiency. In particular, without feedback achieving energy per bit of -1.57 dB requires coding over at least <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> =10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> information bits, while we construct a feedback scheme that transmits a single information bit with energy -1.59 dB and zero error. We also show that unless <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> is very small, approaching the minimal energy per bit does not require using the feedback link except to signal that transmission should stop.
WHY A NEW MANIFESTO ON INCLUSION (2017)

Working in favor of inclusion in various contexts –educational, work, social, etc. – professionals are often asked to express in a clear way, indeed to manifest, their feelings, beliefs, values, but they are also asked to express the competences, aspirations, hopes, purposes, commitments they are manifestly ready to adopt. !ose who work in favor of inclusion, but also those that focus only on researching it, often have to clearly state their likings, their scientific bases and values in order to stimulate active participation in their projects and allow the ‘intersubjective’ control of their appropriate acting. In other words, the need is often felt to plan and make available a sort of checklist that can allow the appraisal of the quality of the interventions underway and checking to what extent, the aims that are set, chosen and defined in the name of inclusion have been reached.
Crash Data Collection: A Windows Case Study (2005)

Reliability is a rapidly growing concern in contemporary personal computer (PC) industry, both for computer users as well as product developers. To improve dependability, systems designers and programmers must consider failure and usage data for operating systems as well as applications. In this paper, we discuss our experience with crash and usage data collection for Windows machines. We analyze results based on crashes in the UC Berkeley EECS department.
Impact of Dietary Fiber and Physical Form on Performance of Lactating Dairy Cows (1986)

Two trials were conducted to study the effects of forage intake and physical form on lactating cow performance. In trial 1, four cows in a 4 X 4 Latin square were fed long alfalfa hay at 28, 36, 45, and 53% of total dry matter plus concentrate. Total dry matter intake was not affected by forage percent. Total chewing time and milk fat percentage increased linearly with increasing forage consumption. Maximum 4% fat-corrected milk production occurred when diets contained 27% neutral detergent fiber and 18% acid detergent fiber. In trial 2, four cows in a 4 X 4 Latin square were fed diets of chopped alfalfa hay and concentrate in proportions to supply 27.4% total ration neutral detergent fiber. Mean particle length measured with an oscillating screen particle separator of the chopped hay was .26, .46, .64, and .90 cm. Total dry matter and forage dry matter intakes and total chewing were not influenced by forage mean particle length. Mean particle length did not affect actual milk or 4% fat-corrected milk production. Depression of milk fat percentage was prevented when forage mean particle length was greater than or equal .64 cm. Apparent digestibility of dietary constituents and rate of passage of hay and concentrate was not influenced by forage intake or physical form.
Optimizing heat shock protein expression induced by prostate cancer laser therapy through predictive computational models (2006)

Thermal therapy efficacy can be diminished due to heat shock protein (HSP) induction in regions of a tumor where temperatures are insufficient to coagulate proteins. HSP expression enhances tumor cell viability and imparts resistance to chemotherapy and radiation treatments, which are generally employed in conjunction with hyperthermia. Therefore, an understanding of the thermally induced HSP expression within the targeted tumor must be incorporated into the treatment plan to optimize the thermal dose delivery and permit prediction of the overall tissue response. A treatment planning computational model capable of predicting the temperature, HSP27 and HSP70 expression, and damage fraction distributions associated with laser heating in healthy prostate tissue and tumors is presented. Measured thermally induced HSP27 and HSP70 expression kinetics and injury data for normal and cancerous prostate cells and prostate tumors are employed to create the first HSP expression predictive model and formulate an Arrhenius damage model. The correlation coefficients between measured and model predicted temperature, HSP27, and HSP70 were 0.98, 0.99, and 0.99, respectively, confirming the accuracy of the model. Utilization of the treatment planning model in the design of prostate cancer thermal therapies can enable optimization of the treatment outcome by controlling HSP expression and injury.
Transmission characteristics of finite-width conductor-backed coplanar waveguide (1993)

This paper presents theoretical and experimental results for a finite-width conductor-backed coplanar waveguide (FW-CBCPW). The guiding characteristics of FW-CBCPW are investigated first by the rigorous method of mode matching. An FW-CBCPW through line is then placed within a test fixture commonly used in laboratories, and the scattering parameters of the through line are obtained theoretically by approximating the FW-CBCPW as a simple system of coupled transmission lines. Experimental results are shown to agree very well with the theoretical ones. In particular, the anomalous behavior observed in the transmission characteristic of the through line is related to the resonant phenomenon of the terminated side planes which are short-circuited at both input and output ends due to the test fixture. Finally, a technique of mode suppression in the side-plane regions is suggested for the improvement of signal transmission over a broad band of frequency spectrum. The effects of extra higher order modes on the transmission characteristics at high frequencies are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>