gebhart/patrepeval huggingface dataset:
Nε−Lysine Acetylation of a Bacterial Transcription Factor Inhibits Its DNA-Binding Activity (2010)

Evidence suggesting that eukaryotes and archaea use reversible N(ε)-lysine (N(ε)-Lys) acetylation to modulate gene expression has been reported, but evidence for bacterial use of N(ε)-Lys acetylation for this purpose is lacking. Here, we report data in support of the notion that bacteria can control gene expression by modulating the acetylation state of transcription factors (TFs). We screened the E. coli proteome for substrates of the bacterial Gcn5-like protein acetyltransferase (Pat). Pat acetylated four TFs, including the RcsB global regulatory protein, which controls cell division, and capsule and flagellum biosynthesis in many bacteria. Pat acetylated residue Lys180 of RcsB, and the NAD(+)-dependent Sir2 (sirtuin)-like protein deacetylase (CobB) deacetylated acetylated RcsB (RcsB(Ac)), demonstrating that N(ε)-Lys acetylation of RcsB is reversible. Analysis of RcsB(Ac) and variant RcsB proteins carrying substitutions at Lys180 provided biochemical and physiological evidence implicating Lys180 as a critical residue for RcsB DNA-binding activity. These findings further the likelihood that reversible N(ε)-Lys acetylation of transcription factors is a mode of regulation of gene expression used by all cells.
Technique for translating light-wave frequency by using an optical ring circuit containing a frequency shifter (1992)

A new technique for the external frequency translation of light waves is proposed. The technique enables the stepwise sweeping of an optical frequency in time over a wide range. The frequency translator is composed of an optical pulse modulator and an optical ring circuit that contains an acousto-optic frequency shifter and an optical amplifier. The pulse launched into the ring circuit undergoes a frequency shift for each complete trip around the ring circuit, and the frequency is translated considerably from the original input pulse. We confirm a frequency translation of as much as 8 GHz for a 1.5-microm light wave, in which the sweeping is strictly linear with respect to time.
Characterization of LOCOS Field Oxide on 4H-SiC Formed by Ar Preamorphization Ion Implantation (2017)

In this letter, the electrical properties of local oxidation of silicon (LOCOS) field oxide formed on 4H-SiC are reported. Moreover, unlike the conventional Si LOCOS process, a simpler method based on Ar preamorphization implantation is proposed. In addition to direct characterization of the field oxide, device properties achieved using LOCOS isolation are compared with those achieved using the conventional chemical vapor deposition oxide isolation to clarify the impact of isolation technology. The results of this letter would be insightful for silicon-carbide-based very-large-scale integration technology.
New organic semiconductors and their device performance as a function of thiophene orientation (2005)

We report a first investigation of two new isomer-pure thieno[f,f′]bis[1]benzothiophenes, i.e.syn and anti with respect to the orientation of the thiophenes along the long axis of the molecule, applied as organic semiconductors in organic field-effect transistors. The field-effect mobility of both regioisomers is substantial and reaches up to 0.12 cm2 V−1 s−1, a value that is at most one order of magnitude lower than the best known organic transistors based on silicon dioxide gate insulators.
A simple and cost-effective protocol for DNA isolation from buccal epithelial cells (2007)

Buccal cells provide a convenient source of DNA for epidemiological studies. The goal of this study was to develop a convenient method to obtain buccal cells from mouthwash samples to be used as a source of DNA, and to evaluate the stability of the DNA in mouthwash solution over time. The procedures used in the method described in this paper avoid the use of any organic solvents. This is achieved by salting out the cellular proteins by dehydration and precipitation with a saturated ammonium acetate solution. The protocol described here is fast, simple to perform, sensitive, economical and several samples can be processed at the same time. The analyses provide consistent evidence that DNA extracted by this methodology is sufficient for several PCR amplifications. The total DNA yield ranged from 5 to 93 microg (median 15 microg, mean 20.71 microg). DNA can be extracted and PCR amplified after storage of mouthwash solution at room temperature for periods of up to 30 days.
OVER FIERHEID IN DE RELIGIEUZE BELEVING (1946)

ZUSAMMENFASSUNG Es ist schwierig, das niederländische Wort „Fierheid” zu übersetzen. Vielleicht nähert sich die Bedeutung des edlen Stolzes diesem Begriffe am meisten. Also eine Untersuchung Ueber Stolz in dem religiösen Erlebnis. Die Einstellung der Untersuchung war phänomenologisch im weitesten Sinne eines SCHELER Z.B., so dass wir auch metaphysische und theologische Erörterungen und Schlussfolgerungen benützten, damit wir eine eingehende Darstellung der Wesenheit dieses „Stolzes” entwerfen könnten. Wir „illustrierten” die Wesensbeschreibung durch mittelniederländische Texte der ausserordentlich genialen und viel zu wenig bekannten HADEWIJCH: ein staunenswertes Beispiel dieses religiösen Stolzerlebnisses. Am Ende wurde auch BEATRIJS VON NAZARETH zitiert. Ausser dem Objekte der Untersuchung dessen Forschung bisher—meinen wir—keine phänomenologische Darstellung gewidmet wurde—eine historische Untersuchung wird man also hier nicht vorfinden—waren wir in der Lage metaphysische Probleme der Gotteslehre aufs neue zu stellen, z.B. der „relatio realis” zwischen Gott und Mensch und der „Reaktion” Gottes den menschlichen religiösen Haltungen gegenüber. Eine Lösung meinten wir in der Sphäre „rein-personalistischer” Betrachtungen zu finden. Opponierten uns also dem mehr „dinglich” eingestellten RUDOLF OTTO in Das Heilige. Das Gefühl des Stolzes „um Gott” is wesentlich in dem religiösen Stolzerlebnis. Eine Steigerung des menschlichen Hochund Selbstgefühls ist eben in der „Hingabe” zu beobachten. Am meisten erscheint der Stolz in der Konfrontation des Menschen mit Gott und in dem mystischen Ringen im Kampfe der Liebe zwischen God und Mensch. Der erste Teil dieser Untersuchung erschien bereits in dieser Zeitschrift: „Zesde Deel, 1943–45, Af- levering II”, S. 185–245.
Bone Mineral Density and Bone Turnover in Asthmatics Treated with Long-Term Inhaled or Oral Glucocorticoids (1998)

Inhaled glucocorticoids are pivotal in maintenance therapy of chronic bronchial asthma; however, conflict exists over their effects on bone and mineral metabolism. We measured bone mineral density (BMD), bone turnover markers, and adrenal steroid hormones in 53 patients (34 female, 19 male) with chronic bronchial asthma who had taken either inhaled beclomethasone or budesonide in doses of > or = 1500 microg/day for at least 12 months to determine pathogenetic mechanisms of bone loss. To account for the effect of prior oral glucocorticoid exposure we divided patients into two groups: one with (OG) and the other without (IG) a past history of maintenance (> 1 month) oral glucocorticoid therapy. Lumbar spine (LS) and proximal femur BMDs were approximately 1 SD lower in men and women taking OG or high-dose IG for chronic bronchial asthma, potentially equivalent to a doubling of the risk of fracture at these sites. Prior exposure to OG in women was also associated with lower LS and proximal femur BMDs, while men were more sensitive to the adverse effects of IG on LS and Ward's triangle BMDs. Bone formation markers were decreased; however, bone resorption marker concentrations were normal. All patients had evidence of suppression of both endogenous glucocorticoid and adrenal androgen production. Both total duration of OG and biochemical bone turnover marker concentrations were negatively related to proximal femur and rib BMDs and total body bone mineral content, but not to LS BMD. These were stronger for bone resorption markers. Uncoupling of ongoing normal bone resorption from suppressed bone formation may therefore contribute to glucocorticoid-associated bone loss in asthma. Adrenal androgen suppression may also increase the susceptibility of postmenopausal women in particular to bone loss with OG. Although the effects of high-dose IG on BMD are associated with lower LS BMD in men, this observation should now be investigated further in prospective studies.
Single-Agent Versus Combination Chemotherapy in Advanced Non–Small-Cell Lung Cancer: The Cancer and Leukemia Group B (study 9730) (2004)

Combination chemotherapy improves response rate and failure-free survival compared with single-agent therapy, but there was no statistically significant difference in the primary end point of overall survival. The results in elderly patients were similar to younger patients. Performance status 2 patients had a superior outcome when treated with combination chemotherapy.
Structural Insight into the Activation Mechanism of Human Pancreatic Prophospholipase A2 (2009)

Pancreatic phospholipase A2 (phospholipase A2 group 1B, G1B) belongs to the superfamily of secreted phospholipase A2 (PLA2) enzymes. G1B has been proposed to be a potential target for diseases such as hypertension, obesity, and diabetes. Human pancreatic prophospholipase A2 (pro-hG1B) is activated by cleavage of the first seven-residue propeptide (phospholipase A2 propeptide, PROP). However, questions still remain on the mode of action for pro-hG1B. In this work, we expressed pro-hG1B in Pichia pastoris and determined the crystal structure at 1.55-A resolution. The x-ray structure demonstrates that pro-hG1B forms a trimer. In addition, PROP occupies the catalytic cavity and can be self-cleaved at 37 degrees C. A new membrane-bound surface and activation mechanism are proposed based on the trimeric model of pro-hG1B. We also propose a new autoproteolytic mechanism for pro-hG1B by the reaction triad Asp49-Arg0-Ser(-2) that is similar to the serine protease catalytic triad.
SenSpire OS: A Predictable, Flexible, and Efficient Operating System for Wireless Sensor Networks (2011)

The development of a modern sensor network is difficult because of the long-term unattended operation mode, diverse application requirements, and stringent resource constraints. To address these issues, we present SenSpire OS, a predictable, flexible, and efficient operating system for wireless sensor networks. We improve system predictability by two-phase interrupt servicing and predictable thread synchronization; we achieve system flexibility by providing a hybrid model for both event-driven programming and multithreaded programming; we retain system efficiency by employing stack sharing and modular design. Moreover, we have designed a three-layer networking stack and an object-oriented programming language (CSpire) to enhance system usability and programming convenience. Having implemented SenSpire OS on three most commonly used sensor node platforms, we evaluate its performance extensively. Results show that SenSpire OS ensures predictable system performance, provides a flexible hybrid model for application programming, and is efficient in resource utilization.
Estimation of Zero-spacing Error due to Phase Shift of Reflected Light in Measuring Magnetic Head Slider's Flying Height by Light Interference. (1992)

"Zero-spacing error (ZSE)", which occurs in measuring flying height by light interference, is caused by phase shift of reflecting light from a magnetic head slider surface. The measured flying height is larger than the true height. The ZSE is measured by two methods. The first measures ZSE by calculating from complex indices of refraction of three kinds of slider material measured by ellipsometer. In the 400∼800 nm wavelength range, ZSEs were confirmed with ±7% accuracy (average). The second method is a direct measuring method using a "standard wedge spacer". The spacer makes a wedge-shaped space between the ceramic samples and the spacer. This method was also used to reconfirm ZSE.
RELATIONSHIPS BETWEEN THE ENDOTHELIN AND NITRIC OXIDE PATHWAYS (1999)

1. In the normal blood vessel, the vascular endothelium regulates the tone of the underlying smooth muscle and the reactivity of blood elements, such as platelets and neutrophils, by the release of mediators, in particular nitric oxide (NO) and endothelin-1 (ET-1). 2. Nitric oxide is a potent vasodilator that also inhibits platelet and neutrophil aggregation and adhesion; ET-1 is the most potent mammalian vasoconstrictor peptide yet found. Recently, much research effort has focused on examining the interactions between these two important mediators. At a simple level, ET-1 acts on specific receptors on the endothelium to increase the release of NO, while NO depresses the production and/or release of ET-1 from endothelial cells. 3. While ET-1 appears to have a relatively small influence on the basal regulation of blood pressure, NO appears central. For example, inhibition of NO production in normotensive animals produces a marked elevation in blood pressure. 4. Conversely, numerous vascular disease states have been associated with elevations in the production and/or release of ET-1 and it has been implicated in the deleterious changes associated with ischaemia-reperfusion injury, subarachnoid haemorrhage and hypertension. In these conditions, NO production may also be increased by the induction of NO synthetic pathways within the vascular smooth muscle. Endothelin-1 may also be produced by the vascular smooth muscle under similar circumstances. 5. Therefore, in pathological states, a new balance between NO and ET-1 production may be central to changes in blood vessel reactivity, smooth muscle proliferation and blood coagulability.
A cyclic octanuclear polyoxoalkoxy vanadate(IV) with an oxalate-binding cavity, [(n-C4H9)4N]2[V8O8(OCH3)16(C2O4)]. Structural comparison with the analogous polymolybdates(V) complex [(n-C4H9)4N]2[Mo8O16(OC2H5)8(C2O4)] (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA cyclic octanuclear polyoxoalkoxy vanadate(IV) with an oxalate-binding cavity, [(n-C4H9)4N]2[V8O8(OCH3)16(C2O4)]. Structural comparison with the analogous polymolybdates(V) complex [(n-C4H9)4N]2[Mo8O16(OC2H5)8(C2O4)]Qin Chen, Shuncheng Liu, and Jon ZubietaCite this: Inorg. Chem. 1989, 28, 25, 4433–4434Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/ic00324a002https://doi.org/10.1021/ic00324a002research-articleACS PublicationsRequest reuse permissionsArticle Views333Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (2000)

Abstract This review offers an introduction to the principles and generic applications of Fourier transform ion cyclotron resonance/mass spectrometry (FTICR/MS), directed to readers with no prior experience with the technique. The fundamental Fourier transform ion cyclotron resonance (FTICR) phenomenon is explained from a simplified theoretical treatment of ion behavior in idealized magnetic and electric fields. The effects of trapping voltage, trap size and shape, and other nonidealities are then manifested mainly as perturbations that preserve the idealized ion behavior modified by appropriate numerical correction factors. Topics include: effect of ion mass, charge, magnetic field, and trapping voltage on ion cyclotron frequency; excitation and detection of ion cyclotron resonance (ICR) signals; mass calibration; mass resolving power and mass accuracy; upper mass limit(s); dynamic range; detection limit, strategies for mass and energy selection for multiple mass spectroscopy (MS n ); ion axialization, cooling, and remeasurement; and means for guiding externally formed ions into the ion trap. The relationship of FTICR/MS to other types of Fourier transform (FT) spectroscopy and to the Paul (quadrupole) ion trap is described. The article concludes with selected applications, an appendix listing accurate fundamental constants needed for ultrahigh‐precision analysis, and an annotated list of selected reviews and primary source publications describing various FTICR/MS techniques and applications in fuller detail.
Soluble CD163 as a Marker of Macrophage Activity in Newly Diagnosed Patients with Multiple Sclerosis (2014)

The sCD163 CSF/serum ratio was significantly increased in patients with MS and may reflect macrophage activation in MS lesions. These results suggest that primary progressive MS also is driven by inflammation in which the innate immune system plays a pivotal role.
Nanoporous Gold: Fabrication, Characterization, and Applications (2009)

Nanoporous gold (np-Au) has intriguing material properties that offer potential benefits for many applications due to its high specific surface area, well-characterized thiol-gold surface chemistry, high electrical conductivity, and reduced stiffness. The research on np-Au has taken place on various fronts, including advanced microfabrication and characterization techniques to probe unusual nanoscale properties and applications spanning from fuel cells to electrochemical sensors. Here, we provide a review of the recent advances in np-Au research, with special emphasis on microfabrication and characterization techniques. We conclude the paper with a brief outline of challenges to overcome in the study of nanoporous metals.
Grid management functions built in PV inverters for distributed power generation (2011)

The performance of the Grid Connected Inverters (GCIs) like Photovoltaic (PV) converters is extremely important related to stable and safe operation of the utility grid. These inverters control features not only cover the renewable energy conversion and active power feeding into the utility grid but furthermore they provide grid voltage stabilization support with reactive power of the grid in case of voltage dips and have a role related to frequency stabilization too. The GCIs support the system operators to meet the power quality standards by means of their control functions and fast response time. Decentralized suppliers must contribute to the control of the grid parameters by delivering active and reactive power. This paper gives an overview on the necessary features of GCIs, the inverter limitations and introduces some simulation and operation results.
Serum Antibody Response to <i>Clostridium botulinum</i> Toxin in Infant Botulism (1982)

A serum antibody response has not been previously demonstrated after infection with Clostridium botulinum. We developed an enzyme immunoassay for measuring serum antibody to C. botulinum toxins A, B, and E. This assay system detected a specific immunoglobulin G and immunoglobulin M antibody response to C. botulinum toxin in two patients with infant botulism.
Laser techniques for chemical analysis (1997)

In this review a wide range of laser-based techniques for chemical analysis is discussed with reference to the principles and practical utilities of each technique. Thus techniques for atomic spectrometry, elemental analysis, molecular spectrometry, LIDAR, photothermal spectrometry and mass spectrometry are considered. Where possible qualitative comparisons are made with alternatives for particular analyses, e.g. atomic absorption and emission spectrometry. Where alternatives do not exist e.g. LIDAR, the practical utility and applications of such techniques are discussed.
Use of low-frequency sinusoidal temperature waves to separate pyroelectric currents from nonpyroelectric currents. Part II. Experiment (1982)

Data are presented on several dielectric materials which typically possess varying degrees of pyroelectric response depending largely on the electrical (poling) and thermal (heating) conditioning of the materials. A measurement technique described in the preceding paper was used to analyze these materials. The results of these measurements are compared with those reported by other workers using different techniques. The strength and simplicity of this method is clearly demonstrated when analyzing materials such as poly(vinylidene fluoride) (PVF2), where the current arising from a heated sample stems from a combination of sources or mechanisms in the material.
Phospholipid Transfer Protein–Deficient Mice Absorb Less Cholesterol (2007)

These results indicate that PLTP deficiency results in reduced cholesterol uptake as well as secretion by the intestine. We suggest that PLTP could be a useful target to lower plasma cholesterol levels, thus reducing atherosclerosis.
LOW TEMPERATURE CONVERSION OF PENTANE WITH ALUMINUM CHLORIDE–METAL SULFATE MIXTURES (1978)

Abstract The mixtures of aluminum chloride and metal sulfate are found to be effective catalysts for the conversion of pentane at low temperatures. For example, when 10 ml of pentane was shaked with the equimolar mixture of AlCl3 and Ti2(SO4)3 (7.5 mmol each) at 28 °C for 3 hr, the pentane conversion of 46 % was obtained with the selectivity to isopentane of 84 %. In the vapor phase conversion, however, the main product was found to be isobutane.
Corneal Development, Limbal Stem Cell Function, and Corneal Epithelial Cell Migration in the<i>Pax6</i><sup>+/−</sup>Mouse (2004)

The correct Pax6 dosage is necessary for normal clonal growth during corneal development, normal limbal stem cell activity, and correct corneal epithelial cell migration. Disruption of normal cell movement in heterozygotes may be the consequence of failure of nonautonomous guidance cues. Degeneration of the corneal surface in aniridia-related keratopathy relates to both a deficiency within the limbal stem cell niche and nonautonomous diversion of corneal epithelial cell migration.
High-Wire Act: HVdc Technology: The State of the Art (2012)

Developed to meet a combination of technical and economic considerations, high-voltage dc (HV dc) was launched in 1954 with the first commercial transmission link between the island of Gotland and the Swedish mainland. Since then, HV dc technology has advanced dramatically, and more than 100 HV dc transmission systems have been installed around the world.