gebhart/patrepeval huggingface dataset:
A Blockchain Framework for Insurance Processes (2018)

We design a distributed platform with blockchain as a system service for supporting transaction execution in insurance processes. The insurance industry is heavily dependent on multiple processes between transacting parties for initiating, maintaining and closing diverse kind of policies. Transaction processing time, payment settlement time and security protection of the process execution are major concerns. Blockchain technology, originally conceived as an immutable distributed ledger for detecting double spending of cryptocurrencies, is now increasingly used in different FinTech systems to address productivity and security requirements. The application of blockchain in FinTech processing requires a deep understanding of the underlying business processes. It supports automated interactions between the blockchain and existing transaction systems through the notion of smart contracts. In this paper, we focus on the design of an efficient approach for processing insurance related transactions based on a blockchain-enabled platform. An experimental prototype is developed on Hyperledger fabric, an open source permissioned blockchain design framework. We discuss the main design requirements, corresponding design propositions, and encode various insurance processes as smart contracts. Extensive experiments were conducted to analyze performance of our framework and security of the proposed design.
Modulation of Sympathetic Coronary Vasoconstriction by Cardiac Renin-Angiotensin System in Human Coronary Heart Disease (2000)

In patients with coronary artery disease, an attenuation of sympathetic coronary vasoconstriction can be obtained by reducing cardiac angiotensin II formation without involving circulating angiotensin II. This suggests a role of the tissue renin-angiotensin system in modulating autonomic cardiac drive in humans.
Analysis of the <i>vhoGAC</i> and <i>vhtGAC</i> Operons from <i>Methanosarcina mazei</i> Strain Gö1, Both Encoding a Membrane‐bound Hydrogenase and a Cytochrome <i>b</i> (1995)

DNA encompassing the structural genes of two membrane-bound hydrogenases from Methanosarcina mazei Gö1 was cloned and sequenced. The genes, arranged in the order vhoG and vhoA as well as vhtG and vhtA, were identified as those encoding the small and the large subunits of the NiFe hydrogenases [Deppenmeier, U., Blaut, M., Schmidt, B. & Gottschalk, G. (1992) Arch. Microbiol. 157, 505-511]. Northern-blot analysis revealed that the structural genes formed part of two operons, both containing one additional open reading frame (vhoC and vhtC) which codes for a cytochrome b. This conclusion was drawn from the homology of the deduced N-terminal amino acid sequences of vhoC and vhtC and the N-terminus of a 27-kDa cytochrome isolated from Ms. mazei C16. VhoC and VhtC contain four tentative hydrophobic segments which might span the cytoplasmic membrane. Hydropathy plots suggest that His23 and His50 are involved in heme coordination. The comparison of the sequencing data of vhoG and vhtG with the experimentally determined N-terminus of the small subunit indicate the presence of a 48-amino-acid leader peptide in front of the polypeptides. VhoA and VhtA contained the conserved sequence DPCXXC in the C-terminal region, which excludes the presence of a selenocysteine residue in these hydrogenases. Promoter sequences were found upstream of vhoG and vhtG, respectively. Downstream of vhoC, a putative terminator sequence was identified. Alignments of the deduced amino acid sequences of the gene clusters vhoGAC and vhtGAC showed 92-97% identity. Only the C-termini of VhoC and VhtC were not similar.
The Effect of Mode of Application of <i>Bacillus subtilis</i> RB14‐C on its Efficacy as a Biocontrol Agent Against <i>Rhizoctonia solani</i> (2006)

Abstract Bacillus subtilis RB14‐C, which produces the antibiotic iturin A, was investigated for its effectiveness as a biocontrol agent against Rhizoctonia solani infecting tomato using seed coating and/or direct introduction of the bacteria to the soil. The ability of RB14‐C to colonize plant roots and produce iturin A in soil, depending on the method of bacterial application, was also determined. Seed coating and the combined treatment (soil and seed bacterization) did not protect seedlings against damping‐off caused by R. solani . By contrast, RB14 introduced only to the soil controlled the disease. The total number of RB14‐C bacteria on the roots of plants grown from coated seeds was significantly lower than on the roots of plants grown in soil mixed with the bacteria. In the combined treatment, application of B. subtilis with seeds to soil preinoculated with this bacterium, at first suppressed the population of RB14‐C in the soil. Then the colonization was generally uniform. The concentration of iturin A in non‐planted soil was highest at the beginning of the experiment (i.e. after application of the bacterial suspension) but then decreased, and was undetectable 3 days after incubation. However, after seed planting the antibiotic was produced again around young roots. Bacteria introduced to the soil as a seed coating also released the antibiotic around the seeds.
When Does Imbalanced Data Require Cost-Sensitive Learning? (2000)

more than Most classification algorithms expect the frequency of examples form each class to be roughly the same. However, this is rarely the case for real-world data where very often the class probability distribution is nonuniform (or, imbalanced). For these applications, the main problem is usually the fact that the costs of misclassifying examples belonging to rare classes differ significantly from the costs of misclasifying examples from classes represented in a higher proportion in the data. Cost-sensitive learning studies and provides methods for the design and evaluation of classification algorithms for arbitrary cost functions. This paper outlines an issue that can occur in the imbalanced data setting but has not been studied, according to our knowledge, in the cost-sensitive learning literature---the situation when the class probability distribution on the training data differs significantly from the class probability distribution test data. We will present a brief overview of cost-sensitive learning methods applied on imbalanced data and we will extend the existing theoretical results for the setting in which training and test class priors are different.
Overexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progression (2000)

The ability to overexpress 6-phosphofructo-2-kinase/fructose 2, 6-bisphosphatase (PFK-2)/(FBPase-2) or a truncated form of the enzyme with only the bisphosphatase domain allowed us to analyze the relative role of the kinase and the bisphosphatase activities in regulating fructose 2,6-bisphosphate (Fru-2,6-P(2)) concentration and to elucidate their differential metabolic impact in epithelial Mv1Lu cells. The effect of overexpressing PFK-2/FBPase-2 resulted in a small increase in the kinase activity and in the activity ratio of the bifunctional enzyme, increasing Fru-2,6-P(2) levels, but these changes had no major effects on cell metabolism. In contrast, expression of the bisphosphatase domain increased the bisphosphatase activity, producing a significant decrease in Fru-2,6-P(2) concentration. The fall in the bisphosphorylated metabolite correlated with a decrease in lactate production and ATP concentration, as well as a delay in cell cycle. These results provide support for Fru-2,6-P(2) as a regulator of glycolytic flux and point out the role of glycolysis in cell cycle progression.
A self-adapting sonar ranging system based on digital polarity correlators (2003)

The logic capacity of programmable logic devices has reached a level which allows their use as digital correlators in sonar signal-processing applications. The devices can be modified at almost any point during use in response to changes in the input data or processing environment. This paper reports on the development of a self-adapting ultrasonic system consisting of digital polarity correlators for multiple-user ranging. The digital signal-processing system is integrated into the single programmable logic device. The system is able to provide good performance in different conditions by automatically changing both the signal that drives the transmitter and the range properties of the matched filter receiver. Such an approach allows distance measurements up to a few metres while still eliminating frequent misreadings caused by crosstalk or external ultrasound sources with the low-cost piezoelectric transducers.
TNF-α Gene Expression in Macrophages: Regulation by NF-κB Is Independent of c-Jun or C/EBPβ (2000)

The interaction of transcription factors is critical in the regulation of gene expression. This study characterized the mechanism by which NF-kappa B family members interact to regulate the human TNF-alpha gene. A 120-bp TNF-alpha promoter-reporter, possessing binding sites for NF-kappa B (kappa B3), C/EBP beta (CCAAT/enhancer binding protein beta), and c-Jun, was activated by cotransfection of plasmids expressing the wild-type version of each of these transcription factors. Employing adenoviral vectors, dominant-negative versions of NF-kappa B p65, and c-Jun, but not C/EBP beta, suppressed (p < 0.05-0.001) LPS-induced TNF-alpha secretion in primary human macrophages. Following LPS stimulation, NF-kappa B p50/p65 heterodimers bound to the kappa B3 site and c-Jun to the -103 AP-1 site of the TNF-alpha promoter. By transient transfection, NF-kappa B p65 and p50 synergistically activated the TNF-alpha promoter. In contrast, no synergy was observed between NF-kappa B p65, with or without NF-kappa B p50, and c-Jun or C/EBP beta, even in the presence of the coactivator p300. The contribution of the upstream kappa B binding sites was also examined. Following LPS stimulation, the kappa B1 site bound both NF-kappa B p50/p65 heterodimers and p50 homodimers. The binding by NF-kappa B p50 homodimers to the kappa B1, but not to the kappa 3, site contributed to the inability of macrophages to respond to a second LPS challenge. In summary, adjacent kappa B3 and AP-1 sites in the human TNF-alpha promoter contribute independently to LPS-induced activation. Although both the kappa B1 and kappa B3 sites bound transcriptionally active NF-kappa B p50/p65 heterodimers, only the kappa B1 site contributed to down-regulation by NF-kappa B p50 homodimers.
USABILITY TESTING OF VIRTUAL KEYBOARD IN TOUCH SCREEN WITH QUESTIONNAIRE METHOD (2014)

A system consists of input, process, and output. User interface is a place for users to interact in the system where one of the functions is as input facility of the system. One of the input tools is keyboard. With the development of touchscreen, then virtual keyboard is required. A good interface must be able to be used easily especially for novice users. The usability testing is required to know the usability level of the interface. A good usability has characteristics of effective to use (effectiveness), efficient to use (efficiency), safe to use (safety), having good utility (utility), easy to learn (learnability) and easy to remember how to use (memorability). Usability testing is an evaluation approach involving users. With usability testing, it is expected that it can give positive inputs in designing an interface especially virtual keyboard interface mainly with the characteristics of easy to learn (learnability), and easy to remember how to use (memorability) so that the resulted design can have good usability level
n-Sec1: a neural-specific syntaxin-bindingprotein. (1994)

We have identified n-Sec1, a rat brain homolog of the yeast Sec1p protein that participates in the constitutive secretory pathway between the Golgi apparatus and the plasma membrane. The rat brain cDNA is predicted to encode a 68-kDa protein with 65% amino acid identity to Drosophila rop, 59% identity to Caenorhabditis elegans unc-18, and 27% identity to Saccharomyces cerevisiae Sec1p. By RNA blot analysis, n-Sec1 mRNA expression is neural-specific. An anti-peptide antiserum directed against the n-Sec1 carboxyl terminus detects a 68-kDa protein in rat brain cytosol and membranes, but not in peripheral tissues. In the presence of syntaxin 1a, a plasma membrane protein implicated in synaptic vesicle docking, n-Sec1 becomes membrane-associated. n-Sec1 binds to syntaxin 1a, 2, and 3 fusion proteins coupled to agarose beads, but not to syntaxin 4 fusion protein or beads coupled to a variety of other proteins. These findings indicate that n-Sec1 is a neural-specific, syntaxin-binding protein that may participate in the regulation of synaptic vesicle docking and fusion.
Use of Siderophores to Type Pseudomonads: The Three Pseudomonas Aeruginosa Pyoverdine Systems (1997)

Eighty-eight Pseudomonas aeruginosa isolates, most of them from the Collection of Bacterial Strains of the Institut Pasteur, Paris, were analysed for their pyoverdine-mediated iron incorporation system by different methods, including pyoverdine isoelectrofocusing analysis, pyoverdine-mediated growth stimulation, immunoblot detection of (ferri)pyoverdine outer-membrane receptor and pyoverdine-facilitated iron uptake. The same grouping of the strains was reached by each of these methods, resulting in the classification of the P. aeruginosa isolates, even those which were devoid of pyoverdine production, into three different siderophore types. Forty-two percent of the strains were identified with the type-strain P. aeruginosa ATCC 15,692 (group I), 42% were identical with the second type-strain P. aeruginosa ATCC 27,853 (group II) and 16% reacted identically with the clinical isolate P. aeruginosa Pa6, whose pyoverdine was recognized in this study to be identical in structure to the pyoverdine produced by a natural isolate, P. aeruginosa strain R. No new pyoverdine species was detected among these strains.
Multiphoton Imaging and Laser Ablation of Rodent Spermatic Cord Nerves: Potential Treatment for Patients With Chronic Orchialgia (2011)

Multiphoton microscopy can identify and ablate nerves selectively in vivo in the rat. It can potentially be used for spermatic cord denervation to treat chronic orchialgia. Such imaging may increase the efficacy of nerve ablation and can avoid the potential risks of testicular atrophy and hydrocele associated with spermatic cord microsurgical denervation.
Forsknings- och djurskyddsmässiga konsekvenser av vävnadsprovtagning/identitetsmärkning genom tåklippning av smågnagare (2001)

Forsknings- och djurskyddsmassiga konsekvenser av vavnadsprovtagning/identitetsmarkning genom taklippning av smagnagare
A simplified purification method for AAV variant by polyethylene glycol aqueous two-phase partitioning (2012)

Adeno-Associated Virus (AAV) has been widely used for in vivo study and preclinical therapy due to its ability to mediate long-term transgene expression, its lack of pathogenicity and low immunogenicity. It has been found that AAV has more than ten serotypes, which each transfect certain types of cells in the viral infected organ. Current methods for purification of different AAV serotypes utilize CsCl or Iodixanol ultrahigh speed density gradient centrifugation, which is expensive and time consuming. We recently developed a simplified method, PEG/(NH(4))(2)SO(4) aqueous two phase partitioning, for purification of AAV serotype 2 and 8. The method does not require ultrahigh speed gradient centrifugation or chromatography. Here we further explore the simplified method for purification of other serotypes of AAV, serotype 6 and 9. This simplified method not only can be used to purify serotype 2 and 8, but also serotype 6 and 9, indicating that a variety of AAV serotypes can be purified by this method.
Facile introduction of ester groups into the pyrrole nucleus via trichloroacetylation and alcoholysis (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile introduction of ester groups into the pyrrole nucleus via trichloroacetylation and alcoholysisJohn W. Harbuck and Henry RapoportCite this: J. Org. Chem. 1972, 37, 23, 3618–3622Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/jo00796a011https://doi.org/10.1021/jo00796a011research-articleACS PublicationsRequest reuse permissionsArticle Views810Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Protease Inhibitors:  Current Status and Future Prospects (2000)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTProtease Inhibitors: Current Status and Future ProspectsDonmienne Leung, Giovanni Abbenante, and David P. FairlieView Author Information Centre for Drug Design and Development, University of Queensland, Brisbane, Queensland 4072, Australia Cite this: J. Med. Chem. 2000, 43, 3, 305–341Publication Date (Web):February 10, 2000Publication History Received12 August 1999Published online10 February 2000Published inissue 1 February 2000https://pubs.acs.org/doi/10.1021/jm990412mhttps://doi.org/10.1021/jm990412mreview-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views9760Altmetric-Citations748LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Inhibitors,Monomers,Peptides and proteins,Reaction products Get e-Alerts
Logical phase-controlled oscillator (1975)

The output from a data selector driven by a polyphase binary oscillator and addressed by a digital counter enables the sum or difference of two frequencies to be selected.
Blind cyclostationary carrier frequency and symbol rate estimation for underwater acoustic communication (2012)

In this paper, we propose a new method for blind carrier frequency and symbol rate estimation based on second order cyclostationary features for underwater acoustic communication. Followed by a coarse carrier frequency and symbol rate estimation via spectral analysis, a cyclostationary based estimation algorithm is developed to provide high resolution estimation of both parameters. Specifically, a short time varying resolution spectrum correlation function and spectrum coherence function algorithm is developed to obtain spectral lines in cyclic frequency domain to accurately estimate (1) varying carrier frequency and Doppler shift caused by relative motion and (2) symbol rate for single carrier communication. Simulations confirm the effectiveness, fast speed and low complexity of the proposed algorithm. The proposed method does not assume any a priori knowledge of the target signal.
Standard Nomenclature for Factor VIII and von Willebrand Factor: A Recommendation by the International Committee on Thrombosis and Haemostasis (1985)

Proposition d'une nouvelle terminologie avec des abreviations nouvelles pour le facteur VIII et le facteur de von Willebrand
Improving photosynthesis and crop productivity by accelerating recovery from photoprotection (2016)

Crop leaves in full sunlight dissipate damaging excess absorbed light energy as heat. When sunlit leaves are shaded by clouds or other leaves, this protective dissipation continues for many minutes and reduces photosynthesis. Calculations have shown that this could cost field crops up to 20% of their potential yield. Here, we describe the bioengineering of an accelerated response to natural shading events in Nicotiana (tobacco), resulting in increased leaf carbon dioxide uptake and plant dry matter productivity by about 15% in fluctuating light. Because the photoprotective mechanism that has been altered is common to all flowering plants and crops, the findings provide proof of concept for a route to obtaining a sustainable increase in productivity for food crops and a much-needed yield jump.
Rapid, accurate genotyping of β‐thalassaemia mutations using a novel multiplex primer extension/denaturing high‐performance liquid chromatography assay (2003)

Beta-thalassaemia is a common inherited disorder of haemoglobin synthesis worldwide, with an estimated 3-10% frequency in certain regions. Rapid, accurate genotyping methodologies for specific, causative mutations of the beta-globin gene are needed for pre- and postnatal screening and diagnosis of this disease in different ethnic populations. In this study, we performed a novel multiplex primer extension (PE) reaction in combination with denaturing high-performance liquid chromatography (DHPLC) for simultaneously detecting and genotyping the five most common molecular lesions in the beta-globin gene [codons (CDs) 41-42 (-TCTT), IVS-2-654 (C-->T), - 28 (A-->G), CD17 (A-->T) and CD71-72 (+ A)] in Chinese populations. This method involved the amplification of beta-globin target sequence followed by a purification step, a multiplex PE reaction that did not require labelled oligonucleotides, and a fully-denaturing DHPLC analysis on the Transgenomic Wave DNA fragment analysis system. In a blinded study, this technique accurately genotyped 100% (120/120) of samples previously characterized by reverse-dot blot and direct sequencing, and was used successfully for prenatal diagnosis of beta-globin mutations in six Chinese families. This study validated the combined PE/DHPLC approach as simple, rapid, highly accurate and cost-effective for use in genotyping common disease-causing mutations, including substitutions, insertions and deletions in beta-thalassaemia, and strongly suggests that this technique can be used successfully in other genetic diseases.
Semi-automated design of a MOS currentmode logic standard cell library from generic components (2005)

This paper describes the design and semi-automated generation of a MOS current-mode logic standard cell library. A set of generic components implementing a wide range of combinational and sequential functions is proposed. The layout of the generic components being parameterized for process design rules and transistor dimensions, the library can be mapped to different generations of CMOS processes. An implementation in 0.18um CMOS technology is presented.