gebhart/patrepeval huggingface dataset:
Tissue Eosinophilia in Relation to Immunopathological and Clinical Characteristics in Hodgkin's Disease (2001)

Eosinophils frequently infiltrate tissues involved by Hodgkin's disease (HD), and blood eosinophilia is frequently observed. However, the clinical significance and the mechanisms underlying eosinophilia need further elucidation. In this study the grade of eosinophilic infiltration (EoI) was evaluated in biopsies from 259 HD-patients. In a selected group (n=32), the numbers of Hodgkin-Reed-Sternberg (HRS)-cells were counted, and the phenotype of small lymphocytes, the expression of cytotoxic lymphocyte-associated proteins, CD3-zeta-chain, HLA-DR, proliferation markers, latent membrane protein 1 (LMP-1) and blood lymphocyte function were evaluated. Samples from 88 HD patients (34%) showed high EoI. Significantly higher EoI was seen in nodular sclerosis 2 (NS2; p<0.001), bulky disease (p<0.05) and in patients <50 years (p<0.05). Patients with high EoI did not differ from the remainder with regard to distribution of sex, stage, B-symptoms, blood lymphocyte function and outcome. HRS-cells were significantly more frequent in NS HD as compared to mixed cellularity (MC) (p<0.001) irrespective of EoI. LMP-1-expression, proliferative fraction and phenotypes of small lymphocytes did not differ between the cases with low and high EoI, respectively. MC HD samples had significantly higher numbers of small cells positive for CD8 (p<0.01), T-cell intracellular antigen-1 (p<0.01) and Granzyme B (p<0.05) than NS. LMP-1-positive cases had significantly higher frequency of CD8-positive cells than LMP-1-negative. In conclusion, high EoI remains a feature of certain clinical subgroups of HD. However, there was no association between the degree of EoI and numbers of HRS-cells, phenotypes of small lymphocytes, EBV status and clinical outcome. Determination of EoI is of limited diagnostic and prognostic clinical value in HD. However, the differences in small cell distribution of CD8, TIA-1, GrB and CD57 between the histopathological groups and between LMP-1-expressing/non-expressing cases may contribute to our understanding of the biology of the disease.
Net Shape Differential Gears - An “Art to Part” Success Story (1996)

<div class="htmlview paragraph">The use of a computer-aided design (CAD) system, when properly implemented, dramatically reduces the time required to take new designs to production. The CAD system furthermore improves 1st time quality of the design and tooling, as well as providing automatic documentation of the manufacturing and part design processes. The author describes the development and implementation of a math based system for designing net shape differential gears with all the contact tooling used to make the net shape gear forgings. This system successfully integrates product design, tool design and manufacturing process into a single system.</div>
Self‐navigated tissue phase mapping using a golden‐angle spiral acquisition—proof of concept in patients with pulmonary hypertension (2013)

The feasibility of measuring myocardial motion using a golden-angle spiral TPM sequence was demonstrated, with an image-based respiratory navigator calculated from the TPM data itself.
Synthesis and stability of minerals in the system MgO-Al2O3-SiO2-H2O (1955)

Phase equilibria in the system MgO- Al 2 O 3 -SiO 2 -H 2 O were studied in order to obtain further information on the stability of metamorphic minerals and mineral assemblages. The equilibria are described in terms of composition triangles, of phases in equilibrium with H 2 O. Seventeen sets or triangles are given to describe changing equilibria with increasing temperature, at a constant water pressure of 10,000 psi. Syntheses of phases and equilibrium data are discussed, along with factors influencing the attainment of equilibrium. At low temperatures montmorillonite solid solutions cover a large field in the high-silica (?) portion of the diagram, whereas mixtures high in magnesia yield aluminian serpentine, in combination with other phases. Alumina hydrates and kaolinite dominate the high-alumina portion of the diagram in this temperature range. Aluminian serpentine at higher temperatures gives way to clinochlore. Cordierite, the only anhydrous ternary phase encountered, is stable in equilibrium with H 2 O above ca. 500°C., and the stable joins, quartz-cordierite(?)- H 2 O and cordierite-spinel-H 2 O, divide the quaternary system into two areas: that part dominated by the alumino-silicates, and the area involving magnesium silicates. In the alumina-silica side of the system pyrophyllite is the hydrate stable to the highest temperature, 575°C; but in the magnesia- silica side, talc is stable to a much higher temperature, 780°C. Application of the data obtained to geologic problems are discussed.
Optimizing The Structure Of Neural NetworksUsing Evolution Techniques (1997)

Evolutionary methods have been widely used to determine the structure of artificial neural networks. In this work, we propose a more efficient implementation which face the above problem, by using a neural network model as general as possible. So, we used a fully connected network, consisting of three parts, the input layer, the output layer and a number of hidden layers. This implementation has been proved, via simulations, that it optimazes the size of the network and gives better results compared with other existing methods, while the use of crossover results to more efficient networks. Furthermore, the random initialization has been proved more efficient, since it reduces significantly the number of the generations needed for the convergence of the algorithm. Finally, some aspects for the convergence of the parallel implementations of the algorithm are discussed.
The TAR Hairpin of Human Immunodeficiency Virus Type 1 Can Be Deleted When Not Required for Tat-Mediated Activation of Transcription (2007)

The human immunodeficiency virus type 1 (HIV-1) RNA genome contains a terminal repeat (R) region that encodes the transacting responsive (TAR) hairpin, which is essential for Tat-mediated activation of gene expression. TAR has also been implicated in several other processes during viral replication, including translation, dimerization, packaging, and reverse transcription. However, most studies in which replication of TAR-mutated viruses was analyzed were complicated by the dominant negative effect of the mutations on transcription. We therefore used an HIV-1 variant that does not require TAR for transcription to reinvestigate the role of TAR in HIV-1 replication. We demonstrate that this virus can replicate efficiently upon complete deletion of TAR. Furthermore, evolution of a TAR-deleted variant in long-term cultures indicates that HIV-1 requires a stable stem-loop structure at the start of the viral transcripts in which the 5'-terminal nucleotides are base paired. This prerequisite for efficient replication can be fulfilled by the TAR hairpin but also by unrelated stem-loop structures. We therefore conclude that TAR has no essential function in HIV-1 replication other than to accommodate Tat-mediated activation of transcription.
The Influence of Consumer Value-Based Factors on Attitude-Behavioral Intention in Social Commerce: The Differences between High- and Low-Technology Experience Groups (2013)

ABSTRACT The purpose of this study is to examine the consumer values (i.e., hedonic, social, and utilitarian value) in choosing restaurants and how these values affect consumers' attitude toward and behavior intentions in the context of social commerce. This study is to develop a comprehensive conceptual framework that empirically examines and explains the salient factors that influence restaurant guests' behavior intentions regarding social commerce. A sample of 232 undergraduate students at a university in the Midwest United States was employed for this study using structural equation modeling. This research provides preliminary evidence that certain value dimensions (i.e., hedonic and social value) affect behavior intentions to use social commerce. In particular, utilitarian value has an influence on attitude toward social commerce, which in turn has a positive influence on consumers' behavior intentions. In addition, the results of this study revealed that there are significant differences between high- and low-technology experience group in the proposed model. Further discussion and implications are provided in the text.
Mobile Peer-Mentoring: An Approach to Make Veterans Seek Mental Health-Care Support a Normality (2014)

Veterans often face great difficulties during the community and family reintegration after military deployment. Mental health problems resulting from war related traumatic experiences often make social readjustment very difficult. Many research suggests that peer-mentorship can be very effective for
Rac Activation Induces NADPH Oxidase Activity in Transgenic COS Cells, and the Level of Superoxide Production Is Exchange Factor-dependent (2002)

Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to induce phagocyte NADPH oxidase activity in a COS-7 cell model in which human cDNAs for essential oxidase components, gp91(phox), p22(phox), p47(phox), and p67(phox), were expressed as stable transgenes. Expression of constitutively active Rac1 in "COS(phox)" cells induced translocation of p47(phox) and p67(phox) to the membrane. Furthermore, translocation of p47(phox) was induced in the absence of p67(phox) expression, even though Rac does not directly bind p47(phox). Rac effector domain point substitutions (A27K, G30S, D38A, Y40C), which can selectively eliminate interaction with different effector proteins, impaired Rac1V12-induced superoxide production. Activation of endogenous Rac1 by expression of constitutively active Rac-guanine nucleotide exchange factor (GEF) derivatives was sufficient to induce high level NADPH oxidase activity in COS(phox) cells. The constitutively active form of the hematopoietic-specific GEF, Vav1, was the most effective at activating superoxide production, despite detection of higher levels of Rac1-GTP upon expression of constitutively active Vav2 or Tiam1 derivatives. These data suggest that Rac can play a dual role in NADPH oxidase activation, both by directly participating in the oxidase complex and by activating signaling events leading to oxidase assembly, and that Vav1 may be the physiologically relevant GEF responsible for activating this Rac-regulated complex.
Evaluation of an antigenic fraction of Taenia hydatigena metacestode cyst fluid for immunodiagnosis of bovine cysticercosis. (1987)

An antigenic fraction (ThFAS) isolated from Taenia hydatigena metacestode cyst fluid was used in an ELISA to detect antibodies to T saginata in experimentally and naturally infected cattle. In 10 calves given 1,000 to 100,000 T saginata eggs (20% to 60% viability), IgG and IgM antibodies were detected in all the calves by post-inoculation week 3. Immunoglobulin G antibody values remained increased until calves were slaughtered at post-inoculation weeks 13 to 26. Six naturally infected calves (determined by postmortem examination) were considered positive, using the ELISA. Shared antigens were demonstrated between ThFAS and T saginata and T crassiceps; there were no shared antigens between ThFAS and Haemonchus contortus or Fasciola hepatica. Specific lectin binding to ThFAS indicated the presence of glycoconjugates. Immunoblot analysis indicated that a low molecular weight polypeptide (10,000 Mr) bears the immunodiagnostic antigen.
Coyote and Raven Talk about Indigenizing Environmental Education: Or Reconfiguring the Shenanigans of Otis O'Dewey Esquire. (2012)

First Nations tricksters, Coyote and Raven, work to indigenize Environmental Education but run up against mainstream languages, technologies, and educational practices. They try to do an end-run around the cognitive backfield, then portage through marginal spaces, but find that working between Indigenous languages and mainstream ones can work best by being conversational and bringing in humour and ways of knowing that do not only privilege post-Enlightenment agency but use understandings that gesture toward localized Indigenous practices and changing West Coast (Canada) geographies.
Gang der Untersuchung (2018)

Kerngesellschaftsrecht – mit diesem Begriff spricht sich die Arbeit für ein neues an die europäischen Verhältnisse angepasstes Verständnis des Kapitalgesellschaftsrechts und eine private Initiative zu dessen Implementierung aus. Hierzu werden als materiell-rechtliche und institutionelle Perspektiven der European Model Company Act und das European Law Institute vor dem Hintergrund ihrer US-amerikanischen Vorbilder, Model Business Corporation Act und American Law Institute, einer kritischen Prüfung unterzogen. Zur Entwicklung des neuen Kapitalgesellschaftsrechtsverständnisses setzt die Arbeit sich mit den dogmatischen und regelungsfunktionalen Grundlagen sowie der Umweltbindung des Kapitalgesellschaftsrechts auseinander. Das neue Verständnis des Kapitalgesellschaftsrechts als Kerngesellschaftsrecht ermöglicht zugleich eine Konturierung der Reichweite der Niederlassungsfreiheit.
The Importance of Interconnection Technologies’ Reliability of Power Electronic Packages (2017)

This chapter deals with the reliability of die interconnections used in plastic discrete power packages, dedicated to on‐board electronic systems used in a wide range of applications such as automotive industry. A complete reliability analysis of two bonding technologies—aluminum wire and ribbon bonding—is proposed. This study is particularly focused on interconnection technologies’ aging, when the package is subjected to thermal cycling or power cycling with high‐temperature swings. For thermal cycling, the experimental reliability test results highlight that wire bond package aging is about 2.5 faster than the ribbon bond package. For power cycling, this acceleration factor is about 1.5. In both cases and whatever the bonding technique, the failure mechanism of the package is of a fatigue‐stress nature. Many failure analysis results show wire bond lift‐off. The degradation of the ribbon bond is more difficult to observe. Thermo‐mechanical simulations using finite elements show a high stress concentration in the heel area. For the wire‐bonding technique, the wire is subjected to repeated flexing and pulling that lead to its lift off. The ribbon‐bonding process shows a higher robustness, thanks to a higher contact surface on the die, the low‐loop profile and the stiffness of the ribbon.
The Role of Basement Membranes in Vascular Development (1990)

Endothelial cells produce and bind to multiple basement membrane components. Fibronectin and interstitial collagens seem to promote migration and proliferation, whereas basement membrane collagen and laminin stimulate attachment and differentiation. Human umbilical vein endothelial cells will rapidly form capillary-like structures when plated on a reconstituted basement membrane gel. This morphological differentiation involves the alignment of the cells followed by their close association with one another and the formation of a central lumen. Using antibodies to basement membrane components, we find that the formation of these vessels is a complex process involving multiple interactions with several matrix components. Synthetic peptides to active sequences in laminin have demonstrated that at least two sites in laminin participate in tube formation. An RGD-containing site on the A chain appears to mediate cell to matrix adhesion, and synthetic RGD-containing peptides block cell to matrix adhesion during tube formation. A YIGSR-containing site on the B1 chain appears to mediate cell to cell adhesion and promote tube formation because synthetic peptides block the strong cell interactions involved in tube formation. Our data with laminin peptides show that for at least one protein, multiple sites are recognized. Such data would also suggest that several cellular receptors are involved in a concerted process in laminin-induced differentiation of endothelial cells. We conclude that vessel formation is a complex, multistep process. Identification of active sites that block this process may have potential use in blocking angiogenesis in diseases such as diabetic retinopathy and Kaposi's sarcoma.
Mitigating static power in current-sensed interconnects (2004)

Interconnects are an increasing concern in recent years, resulting in novel techniques such as current sensing. However these techniques must be designed to tradeoff delay and both dynamic and static power consumption. This paper presents an innovative approach to reduce static power in differential current-sensed interconnects. This system uses a self-timed shut-off system to reduce static currents used to bias the current sense amplifier. Results indicated that the self timed shut-off system reduced static power by 23.4% for a 10mm line in 250nm technology with no overhead in performance. On an average it reduced static power by 9.7% for 4mm-9mm lines over 180nm, 130nm, 100nm and 65nm technologies and 6% from 10mm-15mm line over the same set of technologies as before. Physical design of the system was implemented in 250nm technology along with the implementation of a test circuit, ready to be fabricated. Extensions of this shut-off mechanism may be useful for mitigating leakage power in a variety of interconnect circuits.
Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5 beta-cholanoic acid. (1985)

The complete 1H nuclear magnetic resonance assignments have been made for the common mono-, di-, and trihydroxy 5 beta-cholanoic acids; lithocholic acid, chenodeoxycholic acid, ursodeoxycholic acid, deoxycholic acid, cholic acid, and the unsubstituted parent compound, 5 beta-cholanoic acid, by heteronuclear-correlated two-dimensional NMR. The known 13C chemical shifts of these compounds were used to make the proton resonance assignments, and consistency of the carbon and proton assignments was verified by expected changes due to substituent effects. This has led to clarification of previously published 13C NMR resonance assignments. Addition of the 3 alpha, 7 alpha, and 12 alpha hydroxyl substituent effects derived from the mono- and dihydroxycholanoic acids yielded predicted values for proton chemical shifts of the trihydroxy-substituted 5 beta-cholanoic acid, cholic acid, that agreed well with experimental values. It is suggested that the individual substituent effects can be used to predict proton chemical shifts for hydroxycholanic acids containing other combinations of 3 alpha, 7 alpha, 7 beta, and 12 alpha hydroxyl groups.
Distributed Consistent Data Association (2016)

Data association is one of the fundamental problems in multi-sensor systems. Most current techniques rely on pairwise data associations which can be spurious even after the employment of outlier rejection schemes. Considering multiple pairwise associations at once significantly increases accuracy and leads to consistency. In this work, we propose two fully decentralized methods for consistent global data association from pairwise data associations. The first method is a consensus algorithm on the set of doubly stochastic matrices. The second method is a decentralization of the spectral method proposed by Pachauri et al.. We demonstrate the effectiveness of both methods using theoretical analysis and experimental evaluation.
Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver (2016)

Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcysteine (NAC) with dietary control on biochemical and histologic liver manifestations. Rats were classified into nine groups; normal (I), NAFLD-induced by feeding high-fat diet (HFD; II) for 12 weeks, NAFLD switched to regular diet (RD; III), NAFLD-HFD or -RD treated with MTF in a dose of 150 mg/kg (IV, V), NAC in a dose of 500 mg/kg (VI, VII) or MTF+NAC (VIII, IX) respectively for 8 weeks. After 20 weeks, the rats in group II showed notable steatosis, lobular inflammation, fibrosis accompanied with elevated (<i>P</i> < 0.05) serum alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (γ-GT), cholesterol, triglycerides, LDL, VLDL, leptin, tumor necrosis factor (TNF-α), transforming growth factor (TGF-β1) and hepatic malondialdehyde (MDA) compared with group I. Meanwhile, hepatic superoxide dismutase (SOD), glutathione GSH with serum HDL, adiponectin were significantly decreased (<i>P</i> < 0.05). These changes were to a less extent in group III. MTF or NAC individually resulted in improvement of most of these biochemical and histological parameters. These improvements were more pronounced in the combined groups VIII and IX versus each drug alone. NAC supplementation concomitant with MTF could be beneficial for the treatment of NAFLD and prevention of nonalcoholic steatohepatitis (NASH).
Potential Anticancer Agents.<sup>1</sup> VI. Synthesis of α-Amino-γ-sulfamoylbutyric Acids with Substituents on the Sulfonamide Nitrogen (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotential Anticancer Agents.1 VI. Synthesis of α-Amino-γ-sulfamoylbutyric Acids with Substituents on the Sulfonamide NitrogenCAROL W. MOSHER, R. M. SILVERSTEIN, OSBORNE P. CREWS JR., and B. R. BAKERCite this: J. Org. Chem. 1958, 23, 9, 1257–1261Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/jo01103a005https://doi.org/10.1021/jo01103a005research-articleACS PublicationsRequest reuse permissionsArticle Views233Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts