gebhart/patrepeval huggingface dataset:
Seborrheic keratoses. Scarless removal by curettage and oxidized cellulose (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bidirectional Current-Mode Capacitor Multipliers for On-Chip Compensation (2008)

Single-ended and two-ended bidirectional capacitor multipliers for providing on-chip compensation, soft-start, and fast transient mechanisms are proposed in this paper. The bidirectional current mode capacitor multiplier technique can effectively move the crossover frequency toward to the origin in the start-up period for a smoothly rising of the output voltage. Besides, the small time constant is set by the fast transient control circuit in order to get a higher crossover frequency. Thus, the output voltage can be regulated to its stable value as fast as it can when large load current changes. A test chip fabricated by the Taiwan Semiconductor Manufacturing Corporation (TSMC) 0.35-m process verifies the correctness of the bidirectional current mode capacitor multiplier technique. Experimental results demonstrate the transient speed by our proposed technique is faster than that by conventional control by about 2 times, and there is only about 76% dropout voltage of the conventional design with off-chip compensation. The proposed circuits consume more quiescent current about 10 in single-ended capacitor multiplier and 20 in two-ended capacitor multiplier. With the proposed bidirectional current mode capacitor multiplier technique, the performance of dc-dc converters is improved significantly and the external pins and footprint area are minimized.
Detection of enteroviruses and rhinoviruses in clinical specimens by PCR and liquid-phase hybridization (1995)

A sensitive method based on PCR followed by liquid-phase hybridization for detection of enterovirus and rhinovirus RNAs in clinical specimens and cell culture supernatants is described. RNA was extracted from stool samples, throat swabs, nasopharyngeal aspirates, cerebrospinal fluid, urine, and plasma with a commercial phenol-guanidinium-chloroform reagent and purified on a polysulfone membrane, on which the reverse transcriptase reaction was also done. Two sets of oligonucleotide primers from the 5' noncoding region of picornaviruses were selected for DNA amplification of 153-bp (enterovirus) and 120-bp (rhinovirus) regions. Double-stranded amplicons were digested into single strands with T7 gene 6 exonuclease and quantitated by an assay using a europium-labeled probe, streptavidin- and biotinylated probe-coated microtitration wells, and time-resolved fluorometry. The sensitivity of the assay was about one template molecule when purified coxsackievirus A9 RNA was used. All enterovirus prototype strains, except echoviruses 22 and 23, and clinical isolates grown in cell culture or suckling mice were strongly positive by the enterovirus PCR-hybridization, as were selected prototype strains and untyped isolates of rhinoviruses by the rhinovirus PCR-hybridization. In a series of 100 clinical specimens tested, the results for 92 agreed with virus culture results. The detection method described will be useful in etiopathogenic studies on enteroviruses and rhinoviruses.
Analytical Study of ABS Copolymers Using a Preparative Ultracentrifuge (1975)

A quantitative method has been developed to separate free and graft copolymers in an ABS sample. The ABS powder is dispersed in MEK and then introduced into the cells of a preparative ultracentrifuge. After the reproducibility of the procedure was ascertained, the method was used to determine the grafting parameters of samples polymerized under specific conditions. This analytical technique is well suited to demonstrate how the grafting efficiency or grafting density is influenced by various polymerization conditions such as mercaptan content, monomer flow rate, emulsifier content, or polybutadiene content. The effects of other variables such as temperature, the initiator system, and characteristics of the polybutadiene latex can also be demonstrated.
Functions of OsBZR1 and 14-3-3 proteins in brassinosteroid signaling in rice (2007)

Brassinosteroids (BR) are essential growth hormones found throughout the plant kingdom. BR bind to the receptor kinase BRI1 on the cell surface to activate a signal transduction pathway that regulates nuclear gene expression and plant growth. To understand the downstream BR signaling mechanism in rice, we studied the function of OsBZR1 using reverse genetic approaches and identified OsBZR1-interacting proteins. Suppressing OsBZR1 expression by RNAi resulted in dwarfism, erect leaves, reduced BR sensitivity, and altered BR-responsive gene expression in transgenic rice plants, demonstrating an essential role of OsBZR1 in BR responses in rice. Moreover, a yeast two-hybrid screen identified 14-3-3 proteins as OsBZR1-interacting proteins. Mutation of a putative 14-3-3-binding site of OsBZR1 abolished its interaction with the 14-3-3 proteins in yeast and in vivo. Such mutant OsBZR1 proteins suppressed the phenotypes of the Arabidopsis bri1-5 mutant and showed an increased nuclear distribution compared with the wild-type protein, suggesting that 14-3-3 proteins directly inhibit OsBZR1 function at least in part by reducing its nuclear localization. These results demonstrate a conserved function of OsBZR1 and an important role of 14-3-3 proteins in brassinosteroid signal transduction in rice.
Keeping the Discussion Among Civil Servants Alive: 'Platform of Values' as an Emerging Genre Within the Public Sector in Sweden (2018)

A defining feature of contemporary public authorities in Sweden is the production of texts labelled platform of values or core values. Previous research points to three main factors contributing to this development: an increased interest in ethics in the public sector, new forms of management and control, and the importance of the external promotion of public authorities. This paper focuses on the perspective of civil servants when addressing the research question: What are the most important functions of ‘platform of values’ texts? The paper draws on two types of data – a focus group of senior HR officers and a quanti- tative survey for civil servants. Critical Genre Analysis is presented as a methodological framework for understanding ‘value texts’ as social actions. The results show that ‘plat- form of values’ practices are connected to the creation of the “ethically aware” civil servant; that neither their connection to control over civil servants nor to the external promotion of the authority are directly recognised, whereas their connection to goal achievement is; and that the role of the ‘value texts’ as such has been somewhat overrated in previous research – it is the dialogue about the values that matters.
The UzcRS two‐component system in <i>Caulobacter crescentus</i> integrates regulatory input from diverse auxiliary regulators (2018)

The UzcRS two-component system in Caulobacter crescentus mediates widespread transcriptional activation in response to the metals U, Zn and Cu. Unexpectedly, a screen for mutations that affected the activity of the UzcR-regulated urcA promoter (P<sub>urcA</sub> ) revealed four previously uncharacterized proteins whose inactivation led to metal-independent induction of P<sub>urcA</sub> . Using molecular genetics and functional genomics, we find that these auxiliary regulators control P<sub>urcA</sub> expression by modulating the activity of UzcRS through distinct mechanisms. An ABC transporter with a periplasmic metallo-aminopeptidase domain forms a sensory complex with UzcRS, antagonizing metal dependent stimulation by virtue of its ATPase and peptidase domains. Two MarR-like transcription factors synergistically regulate UzcRS activity by repressing the expression of the membrane proteins UzcY and UzcZ, which stimulate UzcRS activity and enhance its sensitivity to a more environmentally relevant U/Zn/Cu concentration range. Additionally, the membrane protein UzcX, whose expression is positively regulated by UzcR, provides a mechanism of feedback inhibition within the UzcRS circuit. Collectively, these data suggest that UzcRS functions as the core-signaling unit within a multicomponent signal transduction pathway that includes a diverse set of auxiliary regulators, providing further insight into the complexity of signaling networks.
In vitro effect of GF120918, a novel reversal agent of multidrug resistance, on acute leukemia and multiple myeloma cells. (1996)

Resistance to chemotherapy in multiple myeloma (MM) and acute myeloid leukemia (AML) is frequently caused by multiple drug resistance (MDR), characterized by a decreased intracellular drug accumulation. MDR is associated with expression of P-glycoprotein (P-gp). GF120918, an acridine derivative, enhances doxorubicin cell kill in resistant cell lines. In this study, the effect of GF120918 on MDR cell lines and fresh human leukemia and myeloma cells was investigated. The reduced net intracellular rhodamine-123 (Rh-123) accumulation in the MDR cell lines RPMI 8226/Dox1, /Dox4, /Dox6 and /Dox40 as compared with wild-type 8226/S was reversed by GF120918 (0.5-1.0 microM), and complete inhibition of rhodamine efflux was achieved at 1-2 microM. This effect could be maintained in drug-free medium for at least 5 h. GF120918 reversal activity was significantly reduced with a maximum of 70% in cells incubated with up to 100% serum. GF120918 significantly augmented Rh-123 accumulation in vitro in CD34-positive acute leukemia (AML) blasts and CD38-positive myeloma (MM) plasma cells obtained from 11/27 de novo AML and 2/12 refractory MM patients. A significant correlation was observed between a high P-gp expression and GF120918 induced Rh-123 reversal (P=0.0001). Using a MRK16/IgG2a ratio > or = 1.1, samples could be identified with a high probability of GF120918 reversal of Rh-123 accumulation. In conclusion, GF120918 is a promising MDR reversal agent which is active at clinically achievable serum concentrations.
Making the Rounds (2000)

Ad Libitum17 October 2000Making the RoundsGeorge Young, MDGeorge Young, MDBoulder, CO 80304 (Young)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-8-200010170-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail You know her … skinny, blond, pinched mouth, pinched brow, handshakelike a dead trout, paineverywhere, making the rounds, to neurologist,cardiologist, gastroenterologist, psychiatrist, rheumatologist, referredby her PCP (God bless him)to you.She is separated, getting a divorce, can't sleep. System Review lights uplike a pinball machine. Into the ER last week twicefor Demerol for headaches, chest pain.Scheduled foran MRI and a treadmill ECG next week. She asksabout Mayo's. You wonder … would it helpif you could just wrap your arms around her, smooththe damp tendrils of hair from her temple, kissher pale forehead?No! That is not allowed!You ... Author, Article, and Disclosure InformationAffiliations: Boulder, CO 80304 (Young)Corresponding Author: George Young, MD, Boulder Medical Center, 2750 Broadway, Boulder, CO 80304. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 October 2000Volume 133, Issue 8Page: 608KeywordsDeoxyadenosine monophosphateGastroenterology and hepatologyIschemiaMouthPainRheumatic painSleepSystematic reviews ePublished: 17 October 2000 Issue Published: 17 October 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Syntheses and transformations of substituted benzazolyl‐ and tetrazolyl(benzotriazol‐1‐yl)methanes (1996)

Abstract Condensation reactions of o ‐hydroxy‐ and o ‐mercaptoanilines, and o ‐phenylenediamine with (benzotriazol‐1‐yl)acetic acid result in (1,3‐benzazol‐2‐yl)(benzotriazol‐1‐yl)methanes. Cycloaddition of sodium azide to (benzotriazol‐1‐yl)acetonitrile leads to (1,2,3,4‐tetrazol‐5‐yl)(benzotriazol‐1‐yl)methane. The diazolo‐substituted benzotriazolylmethanes thus obtained were mono‐ and di‐alkylated at the methylene group and the displacement of the benzotriazole group by nucleophiles was investigated.
Tunable Ultrathin Membranes with Nonvolatile Pore Shape Memory (2015)

The concept of a responsive nanoporous thin-film gel membranes whose pores could be tuned to a desired size by a specific "molecular signal" and whose pore geometry becomes "memorized" by the gel is reported. The ∼100 nm thick membranes were prepared by dip-coating from a solution mixture of a random copolymer comprising responsive and photo-cross-linkable units and monodisperse latex nanoparticles used as a sacrificial colloidal template. After stabilization of the films by photo-cross-linking the latex template was removed, yielding nanoporous structures with a narrow pore size distribution and a high porosity. The thin-film membranes could be transferred onto porous supports to serve as tunable size-selective barriers in various colloids separation applications. The pore dimensions and hence the membrane's colloidal-particle-size cutoff were reversibly regulated by swelling-shrinking of the polymer network with a specially selected low-molar-mass compound. The attained pore shape was "memorized" in aqueous media and "erased" by treatment in special solvents reverting the membrane to the original state.
Observation of Coherently Controlled Photocurrent in Unbiased, Bulk GaAs (1997)

We demonstrate room temperature coherent generation and control of a directional photocurrent in bulk GaAs via simultaneous one- and two-photon interband absorption processes using phase-related 1 ps or 175 fs pulses at 0.775 and $1.55\ensuremath{\mu}\mathrm{m}$. Electrical currents generated in low-temperature-grown (LT) and normal bulk GaAs are collected via gold electrodes. Current densities as high as $3\mathrm{nA}/\ensuremath{\mu}{\mathrm{m}}^{2}$ in LT-GaAs are measured for injected carrier densities as low as ${10}^{14}{\mathrm{cm}}^{\ensuremath{-}3}$ and for peak irradiances of $18\mathrm{MW}{\mathrm{cm}}^{\ensuremath{-}2}$ ( $1.550\ensuremath{\mu}\mathrm{m}$) and $3\mathrm{kW}{\mathrm{cm}}^{\ensuremath{-}2}$ ( $0.775\ensuremath{\mu}\mathrm{m}$).
The Fabrication of Thin, Freestanding, Single‐Crystal, Semiconductor Membranes (1990)

Freestanding, single‐crystal, semiconductor membranes with thicknesses in the range of a few tens of nanometers to tens of microns are of increasing technological interest today. Their applications range from high speed electronic devices to electromechanical devices and pressure sensors. This review paper identifies two general classes of techniques for producing such thin membranes: dissolution of single‐crystal wafers, and direct growth of single‐crystal membranes. Numerous specific techniques in each general class are discussed. The discussion of each technique includes a brief explanation of the reason why it works, a description of the actual experimental implementation, an analysis of the range of thickness that can be produced, and the crystalline and electrical quality of the membranes. Unusual difficulties with implementing a technique, or special advantages of a technique are also noted. Since this review is intended to aid in the selection of a technique for producing thin semiconductor membranes when one has a particular application in mind, note is made of those applications for which the membranes produced with each technique are particularly well suited.
Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. (1991)

Blood cholesterol concentration was directly related to mortality from coronary heart disease even in those with what was, by Western standards, a "low" cholesterol concentration. There was no good evidence of an adverse effect of cholesterol on other causes of death.
Amphiphilic comb‐shaped polymers from poly(ethylene glycol) macromonomers (1992)

Abstract Comb‐shaped amphiphilic graft copolymers composed of hydrophobic backbones and hydrophilic side chains were prepared by radical copolymerization of poly(ethylene glycol) monomethacrylate macromonomers, and methacrylate and acrylate comonomers in toluene. The copolymerizations were very sensitive to the reaction conditions, and insoluble cross‐linked gels were easily formed. The yields of soluble copolymers were affected by the initiator concentration, the macromonomer concentration, and the choice of chain transfer agents and comonomers. Solubilities of the copolymers in water or methanol were found to depend on the sizes and the numbers of the PEG side chains. The copolymers showed surface activity with CMC:s in the order of 0.1–1.5 g/L and surface tensions of 36–56 dyn/cm. When tested as emulsifiers most of the copolymers gave oil‐in‐water type emulsions at room temperature. Polymers carrying MPEG 2000 side chains were crystalline with melting points of 38–44°C, while those based on PEG 400 and 1000 were mostly amorphous with glass transition temperatures between ‐55 and ‐60°C. © 1992 John Wiley & Sons, Inc.
An Acetal-Based PEGylation Reagent for pH-Sensitive Shielding of DNA Polyplexes (2007)

p-Piperazinobenzaldehyde methoxy poly(ethylene glycol) (mPEG, 5 kDa) acetal was synthesized by the Buchwald-Hartwig coupling reaction from piperazine and p-bromobenzaldehyde mPEG acetal. Introduction of a maleimide moiety yielded a novel acetal-based PEGylation reagent (PEG-acetal-MAL) for pH-sensitive conjugation of PEG to thiol-functionalized biomolecules. For reversible shielding of polyplexes, PEG-acetal-MAL was conjugated to polyethylenimine (PEI). At 37 degrees C, the PEG-acetal-PEI conjugate had a half-life of 3 min at endosomal pH 5.5 and 2 h at physiological pH 7.4, respectively. PEI polyplexes containing PEG-acetal-PEI had a zeta potential of +3 mV and were stable to salt-induced aggregation for 2 h at pH 7.4. In contrast, at endosomal pH, the particles were deshielded and aggregated within 0.5 h. Epidermal growth factor or transferrin receptor-targeted polyplexes shielded with the pH-sensitive PEG-acetal mediated enhanced luciferase gene expression in receptor-expressing target cells (Renca-EGFR or K562) as compared to stably shielded control polyplexes. Thus, the novel PEG-acetal-MAL reagent may present a versatile tool for drug and gene delivery formulations when pH-sensitive PEGylation is preferred.
Rapid processing of perovskite solar cells in under 2.5 seconds (2015)

A rapid annealing technique for CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub>perovskite solar cells is presented.
Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators. (1993)

Complexes of nitric oxide (NO) with nucleophiles, also known as nitric oxide/nucleophile adducts or NONOates, appear to offer many advantages as research tools in cardiovascular pharmacology and may have future clinical potential as well. A wide variety of NONOates can be synthesized simply by exposing various nucleophilic compounds to NO. The products are generally stable as solids and highly soluble in aqueous media. The potent vasodilator activity displayed by select members of this series is endothelium independent and is mediated by the free NO that is released on dissolution, which activates smooth-muscle guanylate cyclase with subsequent intracellular cyclic guanosine monophosphate production. NO release from the NONOate complexes is not catalyzed by exogenous thiol or albumin. The NONOates differ from other currently available nitrovasodilators in that their potency as vasorelaxants correlates closely with data on their first-order rates of spontaneous reversion to NO in simple aqueous buffers. The compounds' properties can be conveniently altered by changing the identity of the nucleophilic residue. Continued work with NONOate complexes may provide useful clinical agents as well as improved tools for probing the bioregulatory roles of NO.
Automatically Extracting Instances of Code Change Patterns with AST Analysis (2013)

A code change pattern represents a kind of recurrent modification in software. For instance, a known code change pattern consists of the change of the conditional expression of an if statement. Previous work has identified different change patterns. Complementary to the identification and definition of change patterns, the automatic extraction of pattern instances is essential to measure their empirical importance. For example, it enables one to count and compare the number of conditional expression changes in the history of different projects. In this paper we present a novel approach for search patterns instances from software history. Our technique is based on the analysis of Abstract Syntax Trees (AST) files within a given commit. We validate our approach by counting instances of 18 change patterns in 6 open-source Java projects.
Pharmacokinetic and Pharmacodynamic Profile of Supratherapeutic Oral Doses of Δ<sup>9</sup>‐THC in Cannabis Users (2013)

Oral Δ(9) -tetrahydrocannabinol (Δ(9) -THC) has been evaluated as a medication for cannabis dependence, but repeated administration of acute oral doses up to 40 mg has not been effective at reducing drug-taking behavior. Larger doses might be necessary to affect cannabis use. The purpose of the present study was therefore to determine the physiological and behavioural effects of oral Δ(9) -THC at acute doses higher than those tested previously. The pharmacokinetic and pharmacodynamic profile of oral Δ(9) -THC, administered in ascending order in 15 mg increments across separate sessions, up to a maximum of 90 mg, was determined in seven cannabis users. Five subjects received all doses and two experienced untoward side effects at lower doses. Δ(9) -THC produced a constellation of effects consistent with previous clinical studies. Low cannabinoid concentrations were associated with significant effects on drug-sensitive measures, although progressively greater levels did not lead to proportionately larger drug effects. Considerable variability in Cmax and tmax was observed. Doses of oral Δ(9) -THC larger than those tested previously can be administered to individuals with a history of cannabis use, although given the pharmacokinetic variability of oral Δ(9) -THC and individual differences in sensitivity, individualized dose adjustment is needed to avoid side effects and maximize therapeutic response.