gebhart/patrepeval huggingface dataset:
Molecular Mimicry of Human Endothelial Cell Antigen by Autoantibodies to Nonstructural Protein 1 of Dengue Virus (2011)

The pathogenesis of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS), both serious complications of dengue virus (DV) infection, remains unclear. In this study, we found that anti-DV NS1 (nonstructural protein 1) polyclonal antibodies cross-reacted with human umbilical vein endothelial cells (HUVECs). We further identified a complex-specific mAb, DB16-1, which could recognize DV NS1 and cross-react with HUVECs and human blood vessels. The target protein of DB16-1 was further purified by immunoaffinity chromatography. LC-MS/MS analysis and co-immunoprecipitation revealed that the target protein of DB16-1 was human LYRIC (lysine-rich CEACAM1 co-isolated). Our newly generated anti-LYRIC mAbs bound to HUVECs in a pattern similar to that of DB16-1. The B-cell epitope of DB16-1 displayed a consensus motif, Lys-X-Trp-Gly (KXWG), which corresponded to amino acid residues 116-119 of DV NS1 and mimicked amino acid residues 334-337 in LYRIC. Moreover, the binding activity of DB16-1 in NS1 of DV-2 and in LYRIC disappeared after the KXWG epitope was deleted in each. In conclusion, DB16-1 targeted the same epitope in DV NS1 and LYRIC protein on human endothelial cells, suggesting that it might play a role in the pathogenesis of DHF/DSS. Future studies on the role of the anti-NS1 antibody in causing vascular permeability will undoubtedly be performed on sera collected from individuals before, during, and after the endothelial cell malfunction phase of a dengue illness.
Model-based exploration of the design space for heterogeneous systems on chip (2003)

The exploration of the design space for heterogeneous reconfigurable systems on chip (SoC) becomes more and more important. As modern SoCs include a variety of different architecture blocks, ensuring flexibility as well as highest performance, it is mandatory to prune the design space in an early stage of the design process in order to achieve short innovation cycles for new products. Therefore, the goal of this work is to provide estimations of implementation specific parameters like throughput rate, power dissipation and silicon area by means of cost functions. A concept for a model based exploration strategy supporting the design flow for heterogeneous SoCs is presented. In order to prove the feasibility of this exploration strategy, first of all operations were implemented on discrete components like DSPs, FPGAs or dedicated ASICs. Implementation parameters are provided for a variety of basic operations frequently required in digital signal processing. These implementation parameters serve as a basis for deriving models for the design space exploration concept.
Delay spreads and channel dynamics measurements at ISM bands (2003)

To understand the potential of indoor radio systems as communication media between portable computers and local area networks, the authors built a wideband indoor radio propagation measurement apparatus. The apparatus operates in the industrial, scientific, and medical (ISM) bands centered around 910 MHz, 2.44 GHz, and 5.8 GHz. They briefly describe the measurement apparatus, the measurement procedures, and the measurement areas in an academic environment, Columbia University. Complex multipath delay profiles were recorded in classrooms, small-room offices, open-layout offices, an auditorium, a library, and a machine room. The effects of both delay spread and channel dynamics on designing a high-speed indoor radio data transmission scheme are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Fine Structure in the Thermal Denaturation of DNA: High Temperature-Resolution Spectrophotometric Studie (1980)

Fine structures which appear in the optical melting profile of DNA are examined from both the experimental and theoretical aspects. After a brief historical survey of the DNA melting experiments during the pre-fine-structure era in Section II, the high temperature-resolution experimental techniques which are essential to the investigation of fine structure are described in Section III. Then, the current status of the high-resolution study is reviewed first by a phenomenological description of the melting profile (Section IV) and then of the refolding profile (Section V), where a general idea about the cooperatively melting region and several factors affecting it is given. Sections VI and VII are devoted to the review of current theoretical works. Several well-established theoretical frameworks which correlate the base sequence with the melting phenomena are examined in terms of their rigorousness and usefulness. The molecular thermodynamic parameters concerning the DNA melting which have been evaluated by several research groups are compared and discussed. Finally, in Section VIII, current ideas on the correlation between the fine structure and genetic functions and genetic maps are reviewed. Some future problems relating to the fine structure are also discussed.
Relaxation of Current Filament due to RFC Technology and Ballast Resistor for Robust FWD Operation (2011)

We have investigated the destruction mechanism of High Voltage (HV) Free Wheeling Diodes (FWD) during a reverse recovery operation. The most possible mode of the destruction phenomena originate in local heating due to current filament at the edge portion of the active area. To achieve a large reverse recovery Safe Operation Area (SOA), we focus on the boundary region between the active area and the termination area. To enforce our Relaxed Field of Cathode (RFC) concept [1, 2], it is more effective for the wider SOA to place a ballast resistance for avoiding the current from crowding around the anode region in the top surface of the diode.
High performance silicon modulator with extremely low loss (2011)

For RF-/microwave-applications, the loss of the current optical silicon modulator (typical ~1 dB/mm) is still too high for commercial using compared with that of Lithium Niobate modulator. Approaches for reducing the loss often compromise with the degradation of the other two key performance parametric including modulation efficiency and switching speed. In this work, we achieved the reduction of the phase shifter loss by optimizing the doping level of the modulator while keeping the modulation efficiency and switching speed still at a high level. 10Gbit/s silicon modulator is realized with 0.7 dB/mm phase shift loss and phase shift efficiency V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> = 3.4V·cm. The phase shift loss can also be reduced to 0.45 dB/mm with efficiency V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">π</sub> = 4.3V·cm. Compensated doping method is utilized to optimize the doping level along the cross section of the phase shifter.
p-Methylbenzyl Hydroperoxide (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTp-Methylbenzyl HydroperoxideE. J. Lorand and E. I. EdwardsCite this: J. Am. Chem. Soc. 1955, 77, 15, 4035–4037Publication Date (Print):August 1, 1955Publication History Published online1 May 2002Published inissue 1 August 1955https://pubs.acs.org/doi/10.1021/ja01620a022https://doi.org/10.1021/ja01620a022research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Replication for web hosting systems (2004)

Replication is a well-known technique to improve the accessibility of Web sites. It generally offers reduced client latencies and increases a site's availability. However, applying replication techniques is not trivial, and various Content Delivery Networks (CDNs) have been created to facilitate replication for digital content providers. The success of these CDNs has triggered further research efforts into developing advanced <i>Web replica hosting systems</i>. These are systems that host the documents of a website and manage replication automatically. To identify the key issues in designing a wide-area replica hosting system, we present an architectural framework. The framework assists in characterizing different systems in a systematic manner. We categorize different research efforts and review their relative merits and demerits. As an important side-effect, this review and characterization shows that there a number of interesting research questions that have not received much attention yet, but which deserve exploration by the research community.
Stereospecific CO<sub>2</sub> Copolymers from 3,5-Dioxaepoxides: Crystallization and Functionallization (2014)

Selective transformation of CO2 into biodegradable polycarbonates (CO2-based copolymers) by the alternating copolymerization with epoxides represents a most promising green polymerization process. Despite the tremendous progress this field has made, most of the CO2-based polycarbonates are known to be amorphous, and their low thermal resistance makes them difficult to use as structural materials. Herein, we report the selective synthesis of highly isotactic CO2 copolymers from meso-3,5-dioxaepoxides in perfectly alternating nature by the enantiopure dinuclear Co(III)-complex-mediated desymmetrization copolymerization under mild conditions. These isotactic CO2-based polycarbonates are typical semicrystalline polymers, possessing melting points (Tm) of 179–257 °C, dependent on the substitute groups at 4-position of the meso-epoxides. As a model monomer of 3,5-dioxa-epoxides, 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane (CXO) was studied in detail in the asymmetric copolymerization with CO2. The isotactic CO2/CXO copolymer (PCXC) with >99% enantioselectivity possesses a high Tm of 242 °C and a decomposition temperature of 320 °C, while its atactic copolymer has a high Tg of up to 140 °C. Moreover, the acid hydrolysis of highly isotactic PCXC was performed to provide stereoregular poly(1,2-bis(hydroxymethyl)ethylene carbonate)s (PCFC) with two hydroxyl groups in a carbonate unit, which showed a remarkable decrease of ∼80 °C in thermal decomposition temperature. This hydroxyl-functionalized CO2 copolymer accords with an unmet need for a readily degradable biocompatible polycarbonate and was further explored to prepare bush copolymers for biomedical and pharmaceutical applications. This approach was initially demonstrated by the hydroxyl groups appended in polycarbonate backbone of a hydroxyl-functionalized terpolymer serving as macroinitiators for direct graft polymerization via organocatalytic lactide ring-opening polymerization to give fully degradable brush polymers with polycarbonate backbones and polylactide side chains. Furthermore, enantiopure dinuclear Co(III)-complex-mediated asymmetric terpolymerization of CO2 with CXO and cyclohexene oxide (CHO) at various feed ratios was carried out in toluene solution, affording optically active terpolymers poly(CHC-co-CXC) with highly enantioselective ring-opening of the both meso-epoxides. These stereospecific terpolymers were found to be crystallizable and their crystallization capacity could be tuned by changing the feed ratio of the epoxides.
Elastic design of fine mechanism in instruments (1984)

Presented is an introduction to an alternative for the kinematic design approach in fine instrument mechanism that was previously given by Furse (1981). It describes purposeful use of elasticity in finite mechanism support design. Explained is the philosophy of flexure supports, the design parameters that are involved and how elasticity can be used to provide controlled linear and angular motion. The content will be of use to designers of mechanical instrument components and is especially relevant to the monolithic moulded plastic and silicon devices. Although the material presented has relevance, elastic load cell design is not covered.
What drives records management? A personal view (1994)

I could have titled this paper: ‘What is records management?’ but that would get us too frisky and argumentative before we have even begun. It's not that the question is uninteresting or irrelevant. Indeed, it is highly relevant. But is it answerable? Maybe I could cheat slightly and leapfrog over the question, and assume that whatever records management (RM) is, it actually does exist. With that out of the way, I want to propose another question: what drives records management? By asking this we may find a more constructive approach to understanding what RM actually is and does. More potently, we may address what RM should be doing, and in turn how we as a diverse group of specialists may apply our skills.
Adaptive equalisation in oversampled subbands (1998)

The potential presence of fractional delays, nonminimum phase parts, and a colouring of the channel output can require adaptive equalisers to adapt very long filters, which can have slow convergence for LMS-type adaptive algorithms. The authors present a novel oversampled subband approach to adaptive equalisation, which can both significantly reduce computational complexity and improve convergence speed.
Ab Initio Study of CO<sub>2</sub> Capture Mechanisms in Aqueous Monoethanolamine: Reaction Pathways for the Direct Interconversion of Carbamate and Bicarbonate (2013)

Ab initio molecular orbital calculations combined with the polarizable continuum model (PCM) formalism have been carried out for a comprehensive understanding of the mechanism of carbon dioxide (CO2) absorption by aqueous amine solutions. CO2 is captured by amines to generate carbamates and bicarbonate. We have examined the direct interconversion pathways of these two species (collectively represented by a reversible hydrolysis of carbamate) with the prototypical amine, monoethanolamine (MEA). We evaluate both a concerted and a stepwise mechanism for the neutral hydrolysis of MEA carbamate. Large activation energies (ca. 36 kcal/mol) and lack of increase in catalytic efficiency with the inclusion of additional water molecules are predicted in both the mechanisms. We also examined the mechanism of alkaline hydrolysis of MEA carbamate at high concentrations of amine (high pH). The addition of OH(-) ion to carbamate anion was theoretically not allowed due to the reduction in the nucleophilicity of the former as a result of microsolvation. We propose an alternative pathway for hydrolysis: a proton transfer from protonated MEA to carbamate to generate the carbamic acid that initially undergoes a nucleophilic addition of OH(-) and subsequent low-barrier reactions leading to the formation of bicarbonate and free MEA. On the basis of the calculated activation energies, this pathway would be the most efficient route for the direct interconversion of carbamate and bicarbonate without the intermediacy of the free CO2, while the actual contributions will be dependent on the concentrations of protonated MEA and OH(-) ions.
Chapapote: Interdependence and the Liberalization of the Oil Industry in Mexico (1993)

INTRODUCTIONAztecs burned what they called chapopote for tribute to the gods.' They smeared the dark, viscous substance on their skin, believing it contained healing properties and also used it for the "practical" purposes of dye and glue. 2 Chapopote, extracted from the earth prior to the 1519 Spanish conquest, was uniquely tied to the native peoples' worship and livelihood.In the late 19th Century, after both domestic and foreign exploration, chapopote or petr6leos became a profit-making commodity.But the profits increasingly ran to foreigners, to whom the Mexican government granted generous extraction rights.In a highly symbolic move, President Ldzaro Cirdenas (1934-1940) expropriated oil fields on March 18, 1938, claiming that foreign capitalists thwarted the sovereignty of the nation. 3 Cirdenas' action further supported Article 27 of the 1917 Mexican Constitution, declaring the nation to be the original owner of all lands and minerals, including "petroleum and all hydrocarbons, solid, liquid or gaseous." 4 By 1940, Cirdenas consolidated all exploration, exploitation, refining and marketing of petroleum into a single state-operated enterprise: Petr6leos Mexicanos or PEMEX.s Like the Aztecs four centuries earlier, oil represents much more to the Mexican people than a commodity for its "practical" purposes.It carries healing qualities, representing a restoration of natural resources to Mexico.Oil is symbolically linked to the Mexican Revolution, representing Mexico's sovereignty in standing up to the largest and most powerful international corporations in the world.'In Mexico's internal politics, oil is an important commodity for labor. 7The expropriation began as a labor dispute 8 , and the Oil Worker's Union has emerged as a key element in the PRI's corporatist structure of government.1.
Elliptic curve cryptography based authentication protocol for low-cost RFID tags (2011)

In these days the RFID technology is used widespread. This technology can be found in the utmost fields of our daily life, e.g. supply-chain management, libraries, access management etc. Since the first RFID Tags possessed very small computational capacity only mathematical and logical operations and one-way hash functions could be used. However, in the last years RFID technology achieved that CPU speed on which PKI systems can be run. In this paper we present our elliptic curve cryptography based authentication protocol which proofs against the well-known attacks. Furthermore, we introduce a performance analysis and a comparison with other EC based protocols. By examining the simulation results we prove that our protocol has better performance characteristics than others or at least equals them.
Hepatitis B vaccination in haemodialysis patients: A randomized clinical trial (2009)

In haemodialysis patients, a short vaccination protocol against hepatitis B did not provide any benefit compared to the standard approach with respect to peak anti-HBs titres or a higher rate of seroprotection at the end of follow up. Other strategies to increase seroconversion rates should be explored, especially in the elderly and in patients with hepatitis C.
Improved Conditioning and Testing Procedures for HMA Moisture Susceptibility (2007)

This report presents the findings of a research project to investigate whether combining the environmental conditioning system with the simple performance test would provide a superior procedure for determining the moisture susceptibility of hot-mix asphalt (HMA). The report will be of particular interest to materials engineers in state highway agencies, as well as to materials suppliers and paving contractor personnel who are responsible for the design and evaluation of HMA.
Salinity Effects on Plasma Electrolytes of Channel Catfish, <i>Ictalurus punctatus</i> (1976)

Plasma sodium and chloride levels of channel catfish (Ictalurus punctatus) increased after a 5-day exposure to 10 and 12 g/liter sodium chloride. Exposure of fish to 4 and 8 g/liter for 5 days resulted in plasma electrolyte levels higher than those of fish kept in aged tap water, but were not different from values usually found in freshwater fish. These observed differences may have been due to handling. Tests were performed during several months and no effect due to season was observed.When fish in July (27 C) were exposed to 10 g/liter sodium chloride, the plasma electrolyte concentration increased for 48 h and then stabilized. Exposure to the same concentration in March (9 C) resulted in a slow increase of plasma electrolytes throughout the 13 days of the experiment. Injection of 100 μg/kg cortisol had no effect on plasma electrolyte increase during 48 h after transfer to 12 g/liter sodium chloride.
High expression of the CD30 molecule in human decidual cells. (1994)

CD30 is a receptor-type membrane protein that belongs to the nerve growth receptor superfamily. It is expressed on Hodgkin's cells and activated lymphocytes, as well as in some human malignancies including malignant lymphomas, embryonal carcinomas, and other mesenchymal tumors. However, whether it is expressed in normal tissues remains unclear. To study the expression and biological function of CD30, we first examined various human tissues by immunohistochemistry. The monoclonal antibody Ber-H2 intensely stained the membranes of decidual and endometrial cells with decidual change in frozen sections. Western blots of these tissues with Ber-H2 revealed bands of 120, 105, and 90 kd as found on CD30-expressing cells. Northern blots of these tissues using a CD30 cDNA probe detected mRNAs of the same molecular mass and variety as those in the positive control cell line HUT 102. These results indicated that CD30 is expressed in human endometrial tissue with decidual change and imply that CD30 expression in endometrial tissue is induced by hormonal control.
Effects of Burn Injury on Insulin Secretion and on Sensitivity to Insulin in the Rat <i>in vivo</i> (1975)

Abstract. Both insulin resistance and impairment of insulin secretion are know to occur in man after injury. The relative importance of these effects was studied in rats 2 h after a non‐lethal 20 % dorsal scald. No impairment of insulin secretion was found after this injury. Concentrations of both blood glucose and plasma insulin were elevated in scalded rats. Scalded rats responded to intravenous glucose injection (1.0 g/kg) with a further rise in plasma insulin concentration, which remained normal for the prevailing blood glucose concentration. However, marked impairment of glucose tolerance was observed, indicating the presence of insulin resistance. After intravenous insulin injection (1.0 U/kg) the initial rate coefficient for fall of blood glucose concentration was significantly lower (p < 0.02) in scalded (mean 3.9% min. −1 ) than in control rats (mean 6.3% min. −1 ). The minimum in blood glucose concentration after insulin injection was reached at 10 min. in control rats, but not until 60 min. after injection in scalded rats. This difference was due to a delay in compensation for the hypoglycaemia in the scalded rats, since the rate of disappearance of insulin measured by injection of a tracer of 125 I‐laelled bovine insulin was not decreased after this injury. It was concluded that the impairment of glucose utilization in scalded rats (Heath and Corney, 1973) is due to decreased sensitivity to insulin rather than to suppression of insulin release.
Stirling and Vuilleumier heat pumps : design and applications (1991)

This is a guide to Stirling and Vuilleumier heat pumps - high efficiency gas heated/external combustion engines which allow virtually any liquid or gaseous fuel to be burned without a decline in performance, and offer reduced emissions and lower noise levels than internal combustion engines, with low maintenance costs and a long service life. They have moved from prototype to practicality in applications as diverse as industrial power plants to space power, from submarine propulsion to air liquefaction.