gebhart/patrepeval huggingface dataset:
Use of a Chlamydia trachomatis DNA probe for detection of ocular chlamydiae (1989)

We examined the efficacy of a Chlamydia trachomatis DNA probe in detecting ocular chlamydiae by comparing it with tissue culture isolation, direct fluorescent-antibody cytology, and clinical eye exams. In a trachoma-endemic area of Nepal, 430 Nepalese villagers were examined according to the World Health Organization trachoma grading scale. Upper tarsal conjunctival specimens from each subject were obtained for DNA probing, tissue culture, and fluorescent-antibody screening. Moderate to severe intensity of inflammation was found in 85 (21%) of 430 people studied. An additional 25 (7.2%) of 345 people with low or no intensity of inflammation also had microbiologically proven infection, which may reflect asymptomatic carriage. Compared with culture, the DNA probe had a sensitivity of 86.9% and a specificity of 91%. For direct fluorescent antibody versus culture, the values were 47.8 and 96.9%, respectively. Results from this study indicate that the DNA probe for C. trachomatis might be considered a valuable epidemiologic tool in screening trachoma-endemic populations for ocular chlamydiae.
Spatial-temporal Bayesian inference for MEG/EEG (2002)

We recently described a new approach to the MEG/EEG inverse problem based on Bayesian Inference [1999]. Unlike almost all other approaches to the inverse problem, this approach does not result in a single "best" solution to the problem. Rather it yields a probability distribution of solutions upon which all subsequent inferences are based. This work demonstrated the utility of Bayesian inference both for including pertinent prior information (anatomical location and orientation, sparseness of regions of activity, limitations on current strength and spatial correlation) and for yielding robust results in spite of the under-determined inverse problem. This previous work focused on the analysis of data at a single point in time. We have extended the spatial-only analysis to a spatial-temporal Bayesian inference analysis of the full spatial-temporal MEG/EEG data set. Preliminary results of this extension are presented.
Integrated Session Control for Peer-to-Peer IPTV Services (2008)

Today's wide deployment of broadband access networks, high development of personal multimedia processing technologies, and high interests in UCC (user created content)s are pushing the P2P (peer to peer) IPTV era to be opened in near future. The P2P IPTV will create a new paradigm for the Internet services. This paper proposes an integrated session control model for the P2P IPTV services and presents the IPTV session control procedures based on the proposed model. The proposed session control model allows the constituent TPS (triple play services) of the P2P IPTV to be controlled in an integrated way. And it enables the QoS (quality of service) requirements of the P2P IPTV services to be appropriately controlled within a session so that the IPTV traffic can be handled in a differentiated way from the conventional Internet access traffic even in case of network congestion. It also incorporates the multicast control services so as to support effective transmission of video broadcasting streams. The proposed P2P IPTV session control model is designed to be based on the standard SIP (session initiation protocol), IGMP (Internet Group Management Protocol), and COPS (common open policy services) protocol. The session control procedures presented in this paper show how the protocols are integrated to support the required session control services for the P2P IPTV.
Implementation of Model Predictive Control for Glucose Regulation on a General Purpose Microprocessor (2006)

In order to effectively control nonlinear and multivariable models, and to incorporate constraints on system states, inputs and outputs (bounds, rate of change), a suitable (sometimes necessary) controller is Model Predictive Control (MPC), also known as receding horizon control and moving horizon control. For processes with slow dynamics and low sampling rates, MPC is typically implemented on a dedicated workstation. In this work we present the implementation of MPC on a general-purpose processor, providing a low-cost, low-power consumption and small in size implementation. In order to test the performance of the embedded MPC we examine a glucose regulation problem. Additionally, profiling results of the performance of the processor are provided.
Hair Morphogenesis <i>in Vitro</i> : Formation of Hair Structures Suitable for Implantation (2008)

Mixed aggregates of murine follicular cells have the ability to develop in culture into proto-hairs that retain the ability to fully develop into hair follicles after implantation. Proto-hairs from human cells could provide a convenient and practical means by which follicular cells could be implanted for efficient hair regeneration to treat hair loss.
Diffusion of water in biological tissues. (1991)

A method is presented for obtaining simple approximate solutions for the problem of self-diffusion in an ordered array of obstacles. Our results are compared with some previous exact and approximate solutions, and we find that our method agrees well with the exact results over a large range of the volume fraction of the obstructions. It is shown that there is an important distinction between measurements of the diffusion coefficient by the capillary flow method and the spin-echo method. The modifications for the spin-echo case are given and applied to recent measurements on the anisotropy of the self-diffusion of water in striated muscle and to measurements on cysts of the brine shrimp. The analysis shows that very large volume fractions of obstructive barriers are required in order to account for the reduction in the diffusion coefficient in biological systems. Thus this model analysis leads to the supposition that a substantial fraction (20-40%) of the cell water is hydration water, or that the diffusion coefficient of the cytoplasmic water is reduced substantially from the free water value. In either case, the conclusion that a substantial fraction of cell water has diffusive properties that are altered by the macromolecules of the cytoplasm seems inescapable. In the case of NMR methodology, the measuring times are such that the values for diffusion are often influenced by the presence of macromolecular structures (obstructions) within the cells. This suggests that obstructions make a significant contribution to the value of the NMR diffusion coefficient and that NMR may have practical value for the evaluation of obstruction effects.
Matrix Metalloproteinase-10 Is Required for Lung Cancer Stem Cell Maintenance, Tumor Initiation and Metastatic Potential (2012)

Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the maintenance and tumorigenicity of mouse lung cancer stem-like cells (CSC). Mmp10 is highly expressed in oncosphere cultures enriched in CSCs and RNAi-mediated knockdown of Mmp10 leads to a loss of stem cell marker gene expression and inhibition of oncosphere growth, clonal expansion, and transformed growth in vitro. Interestingly, clonal expansion of Mmp10 deficient oncospheres can be restored by addition of exogenous Mmp10 protein to the culture medium, demonstrating a direct role for Mmp10 in the proliferation of these cells. Oncospheres exhibit enhanced tumor-initiating and metastatic activity when injected orthotopically into syngeneic mice, whereas Mmp10-deficient cultures show a severe defect in tumor initiation. Conversely, oncospheres implanted into syngeneic non-transgenic or Mmp10(-/-) mice show no significant difference in tumor initiation, growth or metastasis, demonstrating the importance of Mmp10 produced by cancer cells rather than the tumor microenvironment in lung tumor initiation and maintenance. Analysis of gene expression data from human cancers reveals a strong positive correlation between tumor Mmp10 expression and metastatic behavior in many human tumor types. Thus, Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. Our data demonstrate for the first time that Mmp10 is a critical lung cancer stem cell gene and novel therapeutic target for lung cancer stem cells.
CO<sub>2</sub> Adsorption Ability and Thermal Stability of Amines Supported on Mesoporous Silica SBA‐15 and Fumed Silica (2013)

Abstract In this study, monoamine 3‐aminopropyl silane (APS) grafted on silica supports were prepared either by post‐modification of mesoporous template‐free SBA‐15 and nonporous fumed silica with 3‐aminopropyl triethoxysilane (APTES) or by direct synthesis using a reaction mixture of APTES, TEOS and organic template P123. The CO 2 adsorption capacities and efficiencies of amine (defined as CO 2 /N ratio) on APS grafted silica adsorbents as well as the thermal stability of grafted APS were analyzed and further compared with those of multiamine, tetraethylenepentamine (TEPA), loaded on mesoporous SBA‐15 and nonporous fumed silica. The TEPA‐loaded silica adsorbents exhibited higher CO 2 adsorption capacities but lower thermal stability than the APS‐grafted silica adsorbents. The low cost and commercially available nonporous fumed silica was found to be an appropriate support for amine loading. The TEPA‐loaded fumed silica possessed a CO 2 adsorption capacity of 3.97 mmole CO 2 /(g of adsorbent) and a CO 2 /N mole ratio of 0.37 under a 15% CO 2 /N 2 mixed gas flow at 75 °C and 1 atm, which were higher than those of the TEPA‐loaded SBA‐15 due to the less CO 2 diffusion hindrance. Besides, a high stability of TEPA on fumed silica in cyclic adsorption‐desorption of CO 2 over the TEPA loaded on SBA‐15 was observed as well.
赤铁矿动电性质和用二（2-乙基己基）磷酸浮选赤铁矿的研究 (2004)

研究了用二(2-乙基己基)磷酸(D2EHPA)作捕收剂时赤铁矿的可浮性.借助动电研究和可溶性测定法研究了赤铁矿与捕收剂之间的相互作用.在D2EHPA存在时赤铁矿的PZC偏移和铁溶解性的降低表明,D2EHPA可特效地吸附在赤铁矿表面上.D2EHPA捕收剂的吸附是赤铁矿疏水和浮选的必要条件.用D2EHPA作为捕收剂可从赤铁矿与石英人工混合物中优先浮选赤铁矿.
Movie Recommendation System Using Sentiment Analysis From Microblogging Data (2020)

Recommendation systems (RSs) have garnered immense interest for applications in e-commerce and digital media. Traditional approaches in RSs include such as collaborative filtering (CF) and content-based filtering (CBF) through these approaches that have certain limitations, such as the necessity of prior user history and habits for performing the task of recommendation. To minimize the effect of such limitation, this article proposes a hybrid RS for the movies that leverage the best of concepts used from CF and CBF along with sentiment analysis of tweets from microblogging sites. The purpose to use movie tweets is to understand the current trends, public sentiment, and user response of the movie. Experiments conducted on the public database have yielded promising results.
Optimization of the Amount of Additives to AgO Cathodes on High-Drain Pulse Performance of Zn/AgO Cells (2001)

The high-drain pulse performance of a Zn/AgO cell was studied. We found that the amount of additives in the AgO used as a cathode for the cell has an important effect on its performance. Optimization of the amount of cathode additives results in a stable Zn/AgO cell with enhanced high-drain pulse performance. © 2000 The Electrochemical Society. All rights reserved.
IL-10 Regulates Thrombus-Induced Vein Wall Inflammation and Thrombosis, (1998)

Vein wall inflammation associated with venous thrombosis is mediated by an imbalance in proinflammatory as compared with antiinflammatory molecules. We hypothesize that IL-10 is an important antiinflammatory cytokine that influences vein wall inflammation and thrombus propagation during venous thrombosis. To test this hypothesis a model of inferior vena caval thrombosis was used. Studies were performed at sacrifice 2 days after thrombus induction and included leukocyte morphometrics, myeloperoxidase activity, vein wall permeability, thrombus weight, and IL-10 ELISA analysis from the vein wall. IL-10 was elevated in the vein wall during venous thrombosis. Neutralization of IL-10 increased inflammation, while supplementation with rIL-10 demonstrated a dose- and time-dependent decrease in inflammation. Interestingly, a low 2.5-microg rIL-10 dose given at time of initiation of thrombosis most significantly decreased inflammation. Thrombus weight was importantly diminished by reconstitution of IL-10. These studies support an important role for IL-10 in the regulation of thrombus-associated inflammation and thrombosis and suggest that IL-10 could be used as a therapeutic agent in the treatment of venous thrombosis.
Evolution of the Ras-like small GTPases and their regulators (2011)

Small GTPases are molecular switches at the hub of many signaling pathways and the expansion of this protein family is interwoven with the origin of unique eukaryotic cell features. We have previously reported on the evolution of CDC25 Homology Domain containing proteins, which act as guanine nucleotide exchange factors (GEFs) for Ras-like proteins. We now report on the evolution of both the Ras-like small GTPases as well as the GTPase activating proteins (GAPs) for Ras-like small GTPases. We performed an in depth phylogenetic analysis in 64 genomes of diverse eukaryotic species. These analyses revealed that multiple ancestral Ras-like GTPases and GAPs were already present in the Last Eukaryotic Common Ancestor (LECA), compatible with the presence of RasGEFs in LECA . Furthermore, we endeavor to reconstruct in which order the different Ras-like GTPases diverged from each other. We identified striking differences between the expansion of the various types of Ras-like GTPases and their respective GAPs and GEFs. Altogether, our analysis forms an extensive evolutionary framework for Ras-like signaling pathways and provides specific predictions for molecular biologists and biochemists.
On the Use of Suffix Arrays for Memory-Efficient Lempel-Ziv Data Compression (2009)

The Lempel-Ziv 77 (LZ77) and LZ-Storer-Szymanski (LZSS) text compression algorithms use a sliding window over the sequence of symbols, with two sub-windows: the dictionary (symbols already encoded) and the look-ahead-buffer (LAB) (symbols not yet encoded). Binary search trees and suffix trees (ST) have been used to speedup the search of the LAB over the dictionary, at the expense of high memory usage [1]. A suffix array (SA) is a simpler, more compact data structure which uses (much) less memory [2,3] to hold the same information. The SA for a length m string is an array of integers ([1], ...[k], ...a[m]) that stores the lexicographic order of suffix k of the string; sub-string searching, as used in LZ77/LZSS, is done by searching the SA.
THE REACTIONS OF ETHYLENE, HYDROGEN AND THE SATURATED HYDROCARBONS UNDER THE INFLUENCE OF EXCITED MERCURY<sup>1</sup> (1929)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE REACTIONS OF ETHYLENE, HYDROGEN AND THE SATURATED HYDROCARBONS UNDER THE INFLUENCE OF EXCITED MERCURY1Hugh S. Taylor and Douglas G. HillCite this: J. Am. Chem. Soc. 1929, 51, 10, 2922–2936Publication Date (Print):October 1, 1929Publication History Published online1 May 2002Published inissue 1 October 1929https://pubs.acs.org/doi/10.1021/ja01385a008https://doi.org/10.1021/ja01385a008research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gallium arsenide thin films by low-temperature photochemical processes (1987)

Molecular layer epitaxy (MLE) is a new crystal-growth method which is able to produce thin films of single crystal in the accuracy of atomic order at relatively low temperature. In MLE, adsorption and surface reaction processes are controlled by alternate injection of reactant gases. MLE of GaAs was demonstrated in trimethylgallium–AsH3 (TMG–AsH3) and triethylgallium–AsH3(TEG–AsH3) systems on various faces of GaAs substrate; monomolecular layer growth was realized for (100) face in TMG–AsH3 system. The film thickness, electric properties, and surface morphology were studied as a function of substrate surface crystalline orientations. By using mass spectroscopy, adsorption and surface reaction processes of MLE by TMG–AsH3 systems were studied. The formation and migration of Ga complex adsorbate which was produced from TMG, and the surface reaction of adsorbate with AsH3 were clarified. Influence of photoirradiation on the growing film has been investigated by use of excimer lasers. UV light irradiation improved the surface morphology and, in certain instances, also lowered impurity concentrations of the film. From the results of mass spectroscopic measurements and photoirradiation effects, it is supposed that surface migration species is an adsorbate like Ga (CHn)x, x=0 at the temperature higher than 520 °C and x=1 at the temperature lower than 500 °C, in MLE.
Differentiation patterns in the blastic phase of chronic myeloid leukemia. (1983)

The surface antigen phenotype of 30 patients with the blast phase of chronic myeloid leukemia (CML) was determined using a panel of monoclonal antibodies recognizing differentiation antigens of normal myeloid, erythroid, megakaryocyte, and lymphoid cells. Ten patients' cells expressed a phenotype corresponding to an immature myeloid cell and were felt to have "myeloid" blast crisis. None of these myeloid leukemias were TdT+ or responded to vincristine (V) and prednisone (P). Eleven patients expressed a phenotype similar to acute lymphoblastic leukemia cells and probably reflect maturation to an early B lymphocyte. All of these "lymphoid" leukemias were TdT+, and 67% of evaluable patients had a complete response to V and P. One leukemia had the phenotype of an erythroleukemia, one patient's cells expressed the phenotype of megakaryoblastic leukemia, and one leukemia had populations of both myeloid and lymphoid blasts. Six leukemias did not express surface markers characteristic of any lineage and were termed "undifferentiated." This group was heterogeneous with respect to TdT expression, but no patient had a complete response to V and P. Determination of surface antigen phenotype in CML blast crisis thus provides clinically useful information for the structuring of treatment protocols.
Phase transitions in europium doped (NAK)NBO<sub>3</sub>ceramics (1989)

Abstract Specimens of Nax-3yKxEuyNbO3 where x = 0.5 and y = 0.05 and 0.1 have been prepared by ceramic technique. Two phase transitions were observed in dielectric studies. Curie temperature decreases as the concentration of rare earth ion increases. The average grainsize is reduced with the introduction of Eu3+. The monoclinic lattice parameters are calculated from X-Ray studies. There is a remarkable increase in dielectric constant with Eu3+ addition.
Characterization of Prostate Cancer DU145 Cells Expressing the Recombinant Androgen Receptor (2003)

Prostate cancer (PC) develops as a consequence of abnormal androgenic stimulation. Unfortunately, most of the PC cell lines are androgen independent (like DU145), or express mutated forms of androgen receptor (AR). We have produced and characterized a new stably transfected PC line expressing the AR (DU145-AR). Untreated DU145-AR cells showed a lower proliferation rate than mock transfected cells, but responded to testosterone treatment. PSA mRNA, undetectable in mock DU145 cells, was present and upregulated by testosterone in DU145-AR. About 5% of DU 145-AR cells showed modification of morphology and enriched of f-actin after testosterone treatment. Moreover, in DU145-AR plasminogen activator (PA) activity and secreted urokinase type plasminogen activator (uPA) protein were lower than in AR negative cells; again testosterone induced PA activity and uPA protein only in DU145-AR. These results indicate that, in general, the effects of unactivated AR is to suppress function(s) in DU145 cells and the addition of testosterone restores the normal properties associated with the untransfected cells. Some of the effects described may thus be mediated by a ligand-independent activation of AR in DU145 cells.
Enfermedad de Wilson: Una enfermedad rara pero presente (2008)

La enfermedad de Wilson (EW) o degeneracin hepatolenticular, tal y como fue denominada por Kinnier Wilson en 1912 (1), es un trastorno del metabolismo del cobre que se hereda de forma autosmica recesiva (2). Su incidencia a nivel global es de 1 de cada 30.000 habitantes, aunque esta tiene una gran variabilidad geogrfica. La EW se debe a mutaciones en el gen de una ATPasa tipo P (ATP7B) implicada en el transporte del cobre al canalculo biliar y al aparato Trans-Golgi.
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk (2009)

Several defense mechanisms have been developed and maintained during the evolution to protect human cells against damage produced from exogenous or endogenous sources. We examined the associations between bladder cancer and a panel of 652 polymorphisms from 85 genes involved in maintenance of genetic stability [base excision repair, nucleotide excision repair, double-strand break repair (DSBR) and mismatch repair, as well as DNA synthesis and cell cycle regulation pathways] in 201 incident bladder cancer cases and 326 hospital controls. Score statistics were used to test differences in haplotype frequencies between cases and controls in an unconditional logistic regression model. To account for multiple testing, we associated to each P -value the expected proportion of false discoveries ( q -value). Haplotype analysis revealed significant associations ( P < 0.01) between bladder cancer and two genes ( POLB and FANCA ) with an associated q -value of 24%. A permutation test was also used to determine whether, in each pathway analyzed, there are more variants whose allelic frequencies are different between cases and controls as compared with what would be expected by chance. Differences were found for cell cycle regulation ( P = 0.02) and to a lesser extent for DSBR ( P = 0.05) pathways. These results hint to a few potential candidate genes; however, our study was limited by the small sample size and therefore low statistical power to detect associations. It is anticipated that genome-wide association studies will open new perspectives for interpretation of the results of extensive candidate gene studies such as ours.
Size-Based Isolation of Circulating Tumor Cells in Lung Cancer Patients Using a Microcavity Array System (2013)

The MCA system has a potential to isolate significantly more CTCs and CTC clusters in advanced lung cancer patients compared to the CellSearch system.
MR multi-spectral texture analysis using space-frequency information (2004)

A new way to extract texture information from magnetic resonance (MR) data sets is proposed. The approach is based on the recently developed Stockwell transform (ST), a multi-scale localized extension of the Fourier transform. Since the ST provides a space-frequency representation of an image, this property may be exploited to derive texture images using local spatial frequency content of multi-spectral MR exams of multiple sclerosis (MS) patients. As illustrated, the new information can aid detection of sub-clinical abnormalities in cerebral normal appearing white matter in patients with MS.