gebhart/patrepeval huggingface dataset:
Molecular bases of CRM<sup>+</sup> factor X deficiency: a frequent mutation (Ser334Pro) in the catalytic domain and a substitution (Glul02Lys) in the second EGF‐like domain (1995)

The presence of gene lesions in coagulation factor X (FX, Stuart factor) was investigated in asymptomatic subjects with FX deficiency characterized by the presence of dysfunctional molecules in plasma, as demonstrated by the discrepancy between clotting activity and antigen level. A missense mutation (Ser334Pro) in the catalytic domain was found in three unrelated families in both the homozygous and the heterozygous conditions, and also in the compound heterozygous form with the substitution of Lys for 102 Glu. None of the mutations was detected in 40 unrelated subjects from the same geographic area. The Ser334Pro mutation affects a serine protease region characterized by extensive variation in the coagulation factors but conserved in mammalian factor X molecules. The Glu102Lys mutation affects a residue of the second EGF-like module also conserved in protein C. Both mutated residues are surface-exposed and found in protein regions suggested to be involved in macromolecular interactions which are impaired in the dysfunctional molecules.
Relationship between Clinical Response to Therapy and Health-Related Quality of Life Outcomes in Patients with Moderate to Severe Plaque Psoriasis (2008)

Improvement in PASI response of >75% corresponded to improvements in HRQOL outcome measures for patients with moderate to severe psoriasis. PASI 90 or 100 responders had greater improvements in DLQI total score than PASI 75 responders.
Multichannel Nomarski microscope with polarization modulation: performance and applications (1997)

Using a two-dimensional CCD array, a photoelastic modulator, and a commercial Nomarski microscope, we built a differential polarization interferometer. Multichannel lock-in detection of the signal allowed us to reach a shot-noise limit corresponding to 5-pm path differences for a few seconds of recording time. This interferometer was used as a surface profilometer as well as a system for imaging through scattering media.
World Wide Web banner advertisement copy testing (1998)

Explores one of the many exciting advertising research possibilities spawned by the Web, namely the efficacy of banner advertisements designed to lure the browser to an external Web page. Traditional advertising research usually relies on self‐report or memory. With Web advertisement banners, on the other hand, we can track actual behavior. In our pilot study, we demonstrate conclusively that click‐through rate, the percentage of visitors to a Web page clicking on an advertisement banner, can vary according to the advertisement copy. We also find that the imperative call for behavior, "Click here", has a positive effect. These findings, using a new research method with a new medium, open the door to further advertising and communication research on Web advertisement banners.
Proteome profiling—pitfalls and progress (2000)

In this review we examine the current state of analytical methods in proteomics. The conventional methodology using two-dimensional electrophoresis gels and mass spectrometry is discussed, with particular reference to the advantages and shortcomings thereof. Two recently published methods which offer an alternative approach are presented and discussed, with emphasis on how they can provide information not available via two-dimensional gel electrophoresis. These two methods are the isotope-coded affinity tags approach of Gygi <i>et al</i>. and the two-dimensional liquid chromatography–tandem mass spectrometry approach as presented by Link <i>et al</i>. We conclude that both of these new techniques represent significant advances in analytical methodology for proteome analysis. Furthermore, we believe that in the future biological research will continue to be enhanced by the continuation of such developments in proteomic analytical technology.
Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine compared to 13-valent pneumococcal conjugate vaccine in adults ≥65 years of age previously vaccinated with 23-valent pneumococcal polysaccharide vaccine (2018)

PCV15 was generally well tolerated and induced high levels of IgG and OPA antibodies to all 15 serotypes included in the vaccine when given as a single dose to adults ≥ 65 years of age previously vaccinated with PPV23.
Preparation of high-quality hexaferrite thick films by an improved liquid phase epitaxy deposition technique (2003)

In this paper, we report on the deposition of thick and high-quality films of BaM on (111) gadolinium gallium garnet (GGG) and m-plane, (11_00) or (101_0), sapphire (Al/sub 2/O/sub 3/) substrates. The deposition rate is sufficiently high to allow for large batch production. The total thickness ranged from 50 to 200 /spl mu/m for 2 h of the liquid phase epitaxy deposition. Therefore, the growth rate of the films ranged from /spl sim/25 to /spl sim/100 /spl mu/m/h. In previous work, growth rates in BaM films were quite small. Equally important, the ferrimagnetic resonance (FMR) linewidth (/spl Delta/H) was /spl sim/0.068 kOe at 58 GHz for the BaM films on (111) GGG and /spl sim/0.08 kOe at 59.9 GHz for the BaM film on m-plane sapphire substrates. The FMR linewidth films of thick BaM films deposited by pulsed laser deposition in earlier work ranged from 0.5 to 1.2 kOe.
A zeolitic porous lithium–organic framework constructed from cubane clusters (2011)

Reported here is a lithium cubane based zeolitic framework possessing a multi-dimensional channel system. The unique design strategy of adopting the ditopic ligand 4-pyridinol leads to a rigid porous framework with high thermal stability. It has a BET surface area of 440.3 m(2) g(-1) and a H(2) uptake capacity of 108.7 cm(3) g(-1) at 77 K.
Immune tolerance and control of CNS autoimmunity: from animal models to MS patients (2006)

Multiple sclerosis (MS) is a chronic inflammatory disease resulting in demyelination and axonal loss within the CNS. An autoimmune reaction directed against myelin antigens contributes to the disease process. As the CNS has long been considered an immune privileged site, how such an immune response can develop locally has remained enigmatic. Recent data, mostly based on the study of animal models for MS, have shown that the CNS is in fact more permissive to the development of immune responses than previously thought. This observation is counterbalanced by the fact that immune tolerance to myelin antigens can be induced outside the CNS. This review focuses on the mechanisms preventing CNS autoimmunity, which act in three separate tissues. In the thymus, expression of CNS autoantigens promotes partial protection, notably through elimination of autoreactive T cells. In the secondary lymphoid organs, the remaining autoreactive T cells are kept under control by the naturally occurring regulatory T cells of the CD4(+)Foxp3(+) phenotype. In the CNS, multiple mechanisms including the local activation of regulatory T cells further limit autoimmunity. A better understanding of the induction of regulatory T cells, of their mechanisms of action, and of approaches to manipulate them in vivo may offer new therapeutic opportunities for MS patients.
Global Gene Expression Profiling in Escherichia coliK12 (2000)

We have used nylon membranes spotted in duplicate with full-length polymerase chain reaction-generated products of each of the 4,290 predicted Escherichia coli K12 open reading frames (ORFs) to measure the gene expression profiles in otherwise isogenic integration host factor IHF(+) and IHF(-) strains. Our results demonstrate that random hexamer rather than 3' ORF-specific priming of cDNA probe synthesis is required for accurate measurement of gene expression levels in bacteria. This is explained by the fact that the currently available set of 4,290 unique 3' ORF-specific primers do not hybridize to each ORF with equal efficiency and by the fact that widely differing degradation rates (steady-state levels) are observed for the 25-base pair region of each message complementary to each ORF-specific primer. To evaluate the DNA microarray data reported here, we used a linear analysis of variance (ANOVA) model appropriate for our experimental design. These statistical methods allowed us to identify and appropriately correct for experimental variables that affect the reproducibility and accuracy of DNA microarray measurements and allowed us to determine the statistical significance of gene expression differences between our IHF(+) and IHF(-) strains. Our results demonstrate that small differences in gene expression levels can be accurately measured and that the significance of differential gene expression measurements cannot be assessed simply by the magnitude of the fold difference. Our statistical criteria, supported by excellent agreement between previously determined effects of IHF on gene expression and the results reported here, have allowed us to identify new genes regulated by IHF with a high degree of confidence.
Terrain-adaptive transform coding of multispectral data (2002)

Presents a robust and implementable compression algorithm for multispectral imagery with selectable quality level within the near-lossless to visually lossy range. The three-dimensional terrain-adaptive transform-based algorithm involves a one dimensional Karhunen-Loeve transform (KLT) followed by two-dimensional discrete cosine transform (DCT). The images are spectrally decorrelated via the KLT to produce the eigen images. The resulting spectrally decorrelated eigen images are then compressed using the JPEG algorithm. The key feature of this approach is that it incorporates the best methods available to fully exploit the spectral and spatial correlation in the data. The novelty of this technique lies in its unique capability to adaptively vary the characteristics of the spectral decorrelation transformation based upon variations in the local terrain. The spectral and spatial modularity of the algorithm architecture allows the JPEG to be replaced by a totally different coder (e.g., DPCM). However. The significant practical advantage of this approach is that it is leveraged on the standard and highly developed JPEG compression technology. The algorithm is conveniently parameterized to accommodate reconstructed image fidelities ranging from near-lossless at about 5:1 compression ratio (CR) to visually lossy beginning at around 40:1 CR.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Perceptual contributions of blocky, blurry and noisy artifacts to overall annoyance (2003)

In this paper, we create synthetic artifacts that are perceived to be predominantly blocky, blurry or noisy. We present them alone or in various combinations and have subjects rate the perceived strength of each artifact and the overall annoyance of the combined artifacts. We found that a simple linear model with no interactions predicted how the perceived artifacts combine to determine overall annoyance. The estimated coefficients indicate that, when the artifacts are equated in perceived strength, blurriness contributes the most to annoyance followed by noise and then blockiness, although the relative weights of blockiness and noise vary with the video content.
A volume and tone control IC for Hi-Fi audio (1981)

A monolithic IC which contains dual-channel volume control circuits, tone control circuits, and function switches is discussed. The IC has excellent characteristics, such as total harmonic distortion of less than 0.002 percent (at 1 kHz, 300 mV rms input signal) and a signal-to-noise ratio of more than 100 dB (at 300 mV rms input signal, A weighting). SIPOS-gate MOSFET's and polysilicon ion implanted resistors are employed, yielding good signal level accuracy and low distortion.
Abiotic Degradation of Atrazine on Zero-Valen Iron Activated by Visible Light (1995)

Note: Abstracts: American Chemical Society, 209th ACS National Meeting, Anaheim, CA, USA, April 2-7, 1995 Reference LBE-POSTER-1995-009View record in Web of Science Record created on 2005-03-02, modified on 2016-08-08
DNA repair efficiency as a model for personalized therapy with Trabectedin (2007)

A57 Trabectedin is a DNA binding and transcription interacting agent under advanced clinical development with activity in advanced pre-treated sarcoma, ovarian, breast and prostate cancer. Objective responses and tumour control have been noted in patients resistant to conventional therapy. Moreover, the emergence of acquired resistance to Trabectedin in sensitive patients is generally delayed. Such findings suggest a specific genotype in cancer cells correlated with sensitivity to Trabectedin. Experimental data have proposed a unique model of in vitro sensitivity to Trabectedin based on a DNA signature. In contrast with the pattern applicable to platinum salts and to anthracyclines, efficient nucleotide excision repair (NER) machinery clusters with sensitivity to Trabectedin, whereas functional homologous recombinant (HRR) DNA repair correlates with resistance to Trabectedin.  Recent data generated in a retrospective study conducted in paraffin embedded tumor samples from sarcoma and ovarian cancer patients treated with Trabectedin demonstrate an association between low levels of mRNA expression of BRCA1 and both progression free survival (PFS), a median of 4.2 months (mo) for low and 1.8 mo for high levels (p= 0.004) and median overall survival, of 15.4 vs 6.8 mo respectively (p 6mo) 68% vs 0% (p=0.006), (3) PFS rate 69% vs 0% (p=0.005), (4) median PFS 7.1 vs 1.4 mo (p=0.004) and (5) median survival 20.4 vs 5.8 mo (p=0.026), when comparing the sensitive vs the resistant patient subpopulations.  In conclusion, the data generated in this pharmacogenomic study demonstrate a unique molecular signature which constitutes a potential tool for personalized therapy with Trabectedin.
Muscle function after mid-shaft femoral shortening. A prospective study with a two-year follow-up (1994)

We performed isokinetic knee testing to assess thigh muscle function in ten patients (12 legs) before and after mid-shaft femoral shortening averaging 46 mm (27 to 70). Tests were at angular velocities of 60 degrees/sec and 180 degrees/sec, and were performed preoperatively and after 3, 6, 12 and 24 months. Isokinetic tests at two years showed a significant reduction in muscle function in both quadriceps and hamstrings, but recovery of function was significantly better for the hamstrings. There was a linear relationship with correlation of r2 = 0.31 to 0.86 between loss of muscle force at two years and the magnitude of shortening. Long-term loss of muscle force should be expected after a mid-shaft shortening of the femur of more than 10%.
Design and Analysis of Axial Permanent Magnet Couplings Based on 3D FEM (2013)

Magnetic couplings are of considerable interest for many industrial applications because they can transmit torque from a primary driver to a follower, without mechanical contact. In particular, as they allow torque to be transmitted across a separation wall, axial permanent magnetic couplings (APMCs) are well suited for use in isolated systems such as vacuums or high-pressure vessels. This paper deals with the design and analysis of APMCs based on 3D finite element (FE) analysis. Finally, confirming that 3D FE results for the torque of the designed APMCs are validated extensively with the measured results, the validity of the design of the APMCs that satisfies the required specifications is confirmed. With the many advantages mentioned above, a permanent magnet coupling can be applied to a variety of industries.
Automatic segmentation of acoustic musical signals using hidden Markov models (1999)

In this paper, we address an important step toward our goal of automatic musical accompaniment-the segmentation problem. Given a score to a piece of monophonic music and a sampled recording of a performance of that score, we attempt to segment the data into a sequence of contiguous regions corresponding to the notes and rests in the score. Within the framework of a hidden Markov model, we model our prior knowledge, perform unsupervised learning of the data model parameters, and compute the segmentation that globally minimizes the posterior expected number of segmentation errors. We also show how to produce "online" estimates of score position. We present examples of our experimental results, and readers are encouraged to access actual sound data we have made available from these experiments.
(t, n) threshold verifiable multisecret sharing scheme based on the factorisation intractability and discrete logarithm modulo a composite problems (1999)

A new (t, )nthreshold verifiable multisecret sharing ((t, n)-VMSS) scheme, based on the intractability of the factorisation and the discrete logarithm modulo a large composite problems, is proposed, in which the dealer can freely give any set of multiple secrets for sharing, and the shadow held by the participant is not only reusable but also verifiable. The proposed scheme provides efficient solutions against cheating by either the dealer or a participant, and outperforms (t, n)-VMSS schemes against cheating by participants devised by Harn and Chen et al.
Influence of doping on the properties of vanadium oxide gel films (2008)

Effect of doping with H and W on the properties of V2O5 and VO2 derived from V2O5 gel has been studied. It is shown that the treatment of V2O5 in low-temperature RF hydrogen plasma for 1 to 10 min. leads to either hydration of vanadium pentoxide or its reduction (depending on the treatment conditions) to lower vanadium oxides. For some samples, which are subject to plasma treatment in the discharge active zone, a non-ordinary temperature dependence of resistance, with a maxi-mum at T ~ 100 K, is observed. For W-doped VO2 films, it is shown that substitution of V4+ with W6+ results in a decrease of the temperature of metal-insulator transition. Also, it has been shown that the doping of the initial films with ~3 at.% of W reduces the statistical scatter in the thresh-old parameters of the switching devices with S-shaped I-V characteristics on the basis of V2O5 gel films.
A mechanized system for log skidding using a "Winch-mounted steel sled" in the peat swamp forest of Malaysia (2008)

The soft peat soil pose a major problem to the use of heavy machinery for log skidding in the Peat Forest of Sarawak. Hence, in the past, the kuda-kuda system, a manual approach, remained the practical solution. However, increasing labour recruitment difficulties led to the need for an alternative system to the kuda-kuda such as the use of the Winch mounted steel sled. However, information on the Winch mounted steel is still lacking. A continuous time study was therefore, conducted on log skidding using the Winch mounted steel in Bintulu, Sarawak, Malaysia. The objectives of the study were to describe the work components and quantify the production rate. The study identified four basic work elements in the skidding cycle which are travel empty, choke/winch, travel loaded and landing. Travel empty and travel loaded were the two largest elements accounting for 82% or more of basic skidding cycle time. Choke/winch and landing elements accounted for 12.6% and 4.6% respectively. The basic skidding cycle time only contributed 70.7% of gross cycle time due to the occurrences of delays (29.3%). Skid distance was the only independent variable found to influence skidding travel times. The production rate of the sled was 10.58 m3 per hour which was higher than production rate of the kuda-kuda. The study showed the Winch-mounted steel is a potential alternative to the kuda-kuda system for log skidding in the Peat Swamp forests of Sarawak.
Constructing Around Contamination (1994)

When soil and ground water contamination are found at a construction site, completing the project on time and within budget is always a challenge. Typical problems include constraints to dewatering, limited surface space, subsurface obstructions, restrictions to moving and storing contaminated materials on-site, increased Occupational Safety and Health Agency site safety compliance regulations, and coordination with concurrent construction work. But discovery of contamination on a construction site doesn't have to mean big delays and added costs. Three projects--a highway expansion, a condominium development and a refinery upgrade--show how to integrate remediation with construction.
The Statics and the Dynamics of Distribution (1891)

The Statics and the Dynamics of Distribution Get access J. B. Clark J. B. Clark Northampton, Mass. Search for other works by this author on: Oxford Academic Google Scholar The Quarterly Journal of Economics, Volume 6, Issue 1, October 1891, Pages 111–119, https://doi.org/10.2307/1882169 Published: 01 October 1891
PETER D. SCOTT, G.B.E., M.D. 1914–1977 (1978)

Journal Article PETER D. SCOTT, G.B.E., M.D. 1914–1977: In Court and Council Get access G.S.W. G.S.W. Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Criminology, Volume 18, Issue 1, January 1978, Page 4, https://doi.org/10.1093/oxfordjournals.bjc.a046863 Published: 01 January 1978
Cytokine networking of innate immunity cells: a potential target of therapy (2014)

Innate immune cells, particularly macrophages and epithelial cells, play a key role in multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL (interleukin)-1 and TNF (tumour necrosis factor) families initiate the cascade of events by inducing chemokine release from bystander cells and by the up-regulation of adhesion molecules required for transendothelial trafficking of immune cells. Furthermore, innate cytokines produced by dendritic cells, macrophages, epithelial cells and innate lymphoid cells seem to play a critical role in polarization of helper T-cell cytokine profiles into specific subsets of Th1/Th2/Th17 effector cells or regulatory T-cells. Lastly, the innate immune system down-regulates effector mechanisms and restores homoeostasis in injured tissue via cytokines from the IL-10 and TGF (transforming growth factor) families mainly released from macrophages, preferentially the M2 subset, which have a capacity to induce regulatory T-cells, inhibit the production of pro-inflammatory cytokines and induce healing of the tissue by regulating extracellular matrix protein deposition and angiogenesis. Cytokines produced by innate immune cells represent an attractive target for therapeutic intervention, and multiple molecules are currently being tested clinically in patients with inflammatory bowel disease, rheumatoid arthritis, systemic diseases, autoinflammatory syndromes, fibrosing processes or malignancies. In addition to the already widely used blockers of TNFα and the tested inhibitors of IL-1 and IL-6, multiple therapeutic molecules are currently in clinical trials targeting TNF-related molecules [APRIL (a proliferation-inducing ligand) and BAFF (B-cell-activating factor belonging to the TNF family)], chemokine receptors, IL-17, TGFβ and other cytokines.