gebhart/patrepeval huggingface dataset:
MCSE Windows 2000 Professional Exam Cram 2 (Exam Cram 70-210) (2003)

MCSE Windows 2000 Professional Exam Cram 2 is the perfect study guide to help you pass the first exam in Microsoft's 2000 four core OS exams - Installing, Configuring, and Administering Microsoft Windows 2000 Professional (exam 70-210). With this book, you can master the skills and concepts necessary to address examination objectives including: planning, installation, configuration, administration, support, security, and troubleshooting of Windows 2000 Professional. It teaches how to analyze Microsoft's trick questions and distracters by providing practice exam questions arranged in a similar format to the ones found on the actual exam. This book is not intended to teach new material. Instead it assumes that you have a solid foundation of knowledge but can use a refresher on important concepts as well as a guide to exam topics and objectives. This book focuses exactly on what you need to get past the exam - it features test-taking strategies, time-saving study tips, and a special Cram Sheet that includes tips, acronyms, and memory joggers not available anywhere else. The series is supported online at several Web sites: examcram.com, informit.com, and cramsession.com.The accompanying CD features PrepLogic™ Practice Tests, Preview Edition. This product includes one complete PrepLogic Practice Test with approximately the same number of questions found on the actual vendor exam. Each question contains full, detailed explanations of the correct and incorrect answers. The engine offers two study modes, Practice Test and Flash Review, full exam customization, and a detailed score report.
A supply noise insensitive PLL with a rail-to-rail swing ring oscillator and a wideband noise suppression loop (2017)

This paper presents a supply noise insensitive digital phase-locked loop (PLL) using a wide bandwidth noise suppression loop (NSL). Unlike previous techniques using regulation or calibration on the voltage-controlled oscillator (VCO) that lead to voltage headroom reduction, the proposed approach employs a wide bandwidth feedback loop around the oscillator, which suppresses supply noise without any headroom loss. The proposed dual loop PLL is implemented in 65nm CMOS, achieving spur suppression of about 30dB near PLL loop bandwidth, while consuming 2.73mW at 3.2GHz output.
Histone Deacetylases SRT1 and SRT2 Interact with ENAP1 to Mediate Ethylene-Induced Transcriptional Repression (2018)

Ethylene plays pleiotropic roles in plant growth, plant development, and stress responses. Although the effects of ethylene on plants are well documented, little is known about molecular-level events that result in transcriptional repression during the ethylene response. In this study, we found that two histone deacetylases, SRT1 and SRT2, interact with ENAP1, which associates with EIN2 in the nucleus. Genetic and transcriptome analyses revealed that SRT1 and SRT2 are required for negative regulation of certain ethylene-responsive genes. The acetylation of HISTONE3 at K9 (H3K9Ac) is specifically regulated by SRT1 and SRT2 in ethylene-repressed genes. In addition, the <i>srt1 srt2</i> double mutation in <i>Arabidopsis thaliana</i> suppresses both the <i>ENAP1ox</i> and the <i>EIN3ox</i> constitutive ethylene response phenotypes, and the ethylene-induced transcriptional repression observed in <i>EIN3ox</i> plants is derepressed in the <i>EIN3ox/srt1 srt2</i> mutant. SRT2 and ENAP1 both bind to promoter regions of genes negatively regulated by ethylene, reducing H3K9Ac levels and resulting in transcriptional repression. This work establishes a mechanism by which histone deacetylases SRT1 and SRT2 interact with ENAP1 to mediate transcriptional repression by regulating the levels of H3K9 acetylation in the ethylene signaling.
INVESTIGATION OF THE IMPACT OF CELLULOSE ACETATE COATING ON THE RELEASE PATTERN OF FREELY SOLUBLE DRUG: METOPROLOL SUCCINATE (2015)

This study is aimed to develop and evaluate cost-effective cellulose acetate (CA)-polyvinyl pyrrolidone (PVP) film coating that can effectively control the release of freely water soluble drug, metoprolol succinate (MS) and to match that of release profile with its marketed tablet formulation. Simple core tables of MS were compressed and coated with a solution composed of semipermeable rate controlling polymer, CA and water soluble pore forming polymer, PVP. Drug-excipient interaction was investigated by both physical observation and differential scanning calorimetry (DSC). The effect of formulation parameters such as the ratio of CA to PVP, tablet coating weight gain, effect of pH on the in-vitro drug release were evaluated. Surface morphology of the CA coating membrane was examined by scanning electron microscope (SEM). Release profile of the optimized formulation at different pH conditions was determined and the similarity factor (f2) with marketed tablet release profile was calculated. It was observed that drug release rate increased with a decrease in the ratio of cellulose acetate to PVP and decreased with increased weight gain of the coating membrane. Among all the formulations, the formulation with CA and PVP at a ratio of 85:15 %w/w and 9 % weight gain showed matching release profile to the marketed tablet formulation with f2 value of 72.25. Developed MS formulation showed pH independent drug release. This study proved that CA-PVP polymer coating could effectively control the release rate of freely water soluble drugs for up to 24 h. Once a day CR formulation of metoprolol succinate pharmaceutically equivalent to marketed formulation was developed.
Individual Modifications in Body Contour Surgery: The ???Limited??? Abdominoplasty (1986)

Stretching of the abdominal wall and skin following pregnancy or excessive weight gain may be limited to the infraumbilical area. In these patients, abdominal repair may be accomplished with a shorter incision and without the necessity for relocating the umbilicus with its attendant visible scar. Forty patients are presented in whom excellent aesthetic repairs were effected through short curvilinear, low abdominal incisions with removal of a modest amount of excess skin. Fascial plication from pubis to umbilicus or above is facilitated by buried figure-of-eight sutures. Suction-assisted lipectomy may be employed as an adjunct. Recovery is facilitated by the reduced incision line length, reduced undermined area, and absence of tension in the midline skin incision, such as may occur in a standard abdominoplasty in which large amounts of panniculus and skin are removed with a complete repair of the abdominal wall. The limited abdominoplasty may be safely performed with ketamine-diazepam anesthesia in an office surgical center. Major complications are few and generally reflect the unpredictable nature of the elasticity of the abdominal skin.
Advanced Signal Processing Tools for the Vibratory Surveillance of Assembly Faults in Diesel Engine Cold Tests (2010)

This paper addresses the use of several signal processing tools for monitoring and diagnosis of assembly faults in diesel engines through the cold test technology. One specific fault is considered here as an example: connecting rod with incorrectly tightened screws. First, the experimental apparatus concerning the vibration tests is introduced. Subsequently, the dynamic analysis of the engine has been carried out in order to calculate the connecting rod forces against the crankpin for predicting the position where mechanical impacts are expected. Then, a vibration signal model for this type of faults is introduced. It deals with the cyclostationary model in which the signal is subdivided into two main parts: deterministic and nondeterministic. Finally, the acceleration signals acquired from the engine block during a cold test cycle at the end of the assembly line are analyzed. For quality control purposes in order to obtain reliable thresholds for the pass/fail decision, a method based on the image correlation of symmetrized dot patterns is proposed. This method visualizes vibration signals in a diagrammatic representation in order to quickly detect the faulty engines in cold tests. Moreover, the fault identification is discussed on the basis of the cyclostationary model of the signals. The first-order cyclostationarity is exploited by the analysis of the time synchronous average (TSA). In addition, the residual signal is evaluated by subtracting the TSA from the raw synchronized signal, and thus, the second-order cyclostationarity analysis is developed by means of the Wigner–Ville distribution (WVD), Wigner–Ville spectrum (WVS), and mean instantaneous power. Moreover, continuous wavelet transform is presented and compared with the WVD and WVS.
Jensen-Shannon divergence as a measure of distinguishability between mixed quantum states (2005)

We discuss an alternative to relative entropy as a measure of distance between mixed quantum states. The proposed quantity is an extension to the realm of quantum theory of the Jensen-Shannon divergence (JSD) between probability distributions. The JSD has several interesting properties. It arises in information theory and, unlike the Kullback-Leibler divergence, it is symmetric, always well-defined, and bounded. We show that the quantum JSD shares with the relative entropy most of the physically relevant properties, in particular those required for a ``good'' quantum distinguishability measure. We relate it to other known quantum distances and we suggest possible applications in the field of the quantum information theory.
INVERSION OF PERMEABILITY FROM THE FULL WAVEFORM ACOUSTIC LOGGING DATA (1995)

The charts, which are used to inverse formation permeability from the full waveform acoustic logging data, are founded on base of the strict Biot's theory of the porous formation.In order to test capability of the charts, both the synthetic full waveforms and the field data are processed using the charts, respectively, the resulting permeabilities are compared with the theoretlcal values and the core measurements.
A full color AMLCD with NVG class B compatibility (1992)

A full color active-matrix liquid crystal display (AMLCD) with night-vision-goggle (NVG) compatibility is reported. The display is a 5-in-diagonal high-resolution triad (RGB) color pixel with 80*108 color groups per inch (H/V). It has a specially designed high-brightness backlight with low profile and the above-mentioned NVG characteristics. The color coordinates of the unit are almost identical to those of the display without NVG filter, preserving the red color coordinates. This display has full avionic characteristics, such as high contrast at high ambient light and extended temperature range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The behaviour of recent isolates of human respiratory coronavirus in vitro and in volunteers: Evidence of heterogeneity among 229E‐related strains (1984)

Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains were serologically related to 229E, but these isolates produced colds with a frequency and severity that contrasted with the effects of 229E itself. Tests on volunteers' preinfection sera showed that the prevalence of antibody to 229E had increased during the period 1961-1979 and that during 1977-1979 only 11% of subjects had no neutralising antibody against 229E. Susceptibility to the 229E-related isolates PR and TO was associated with low preinfection serum neutralising antibody against the homologous virus, and paired sera frequently showed fourfold or greater antibody rises, most commonly against the homologous strain. Volunteers infected with TO were immune when reinoculated with the same strain approximately 1 year later, but other similar volunteers were at least partly susceptible to infection with a heterologous 229E-related virus after similar time intervals. Although the strains of HCV that were grown in tissue culture were all related to the prototype 229E, they appeared not to be identical with it, and this heterogeneity is probably a significant factor in the epidemiology of HCV infections.
Baculovirus-Mediated Gene Delivery into Mammalian Cells Does Not Alter Their Transcriptional and Differentiating Potential but Is Accompanied by Early Viral Gene Expression (2006)

Gene delivery to neural cells is central to the development of transplantation therapies for neurological diseases. In this study, we used a baculovirus derived from the domesticated silk moth, Bombyx mori, as vector for transducing a human cell line (HEK293) and primary cultures of rat Schwann cells. Under optimal conditions of infection with a recombinant baculovirus containing the reporter green fluorescent protein gene under mammalian promoter control, the infected cells express the transgene with high efficiency. Toxicity assays and transcriptome analyses suggest that baculovirus infection is not cytotoxic and does not induce differential transcriptional responses in HEK293 cells. Infected Schwann cells retain their characteristic morphological and molecular phenotype as determined by immunocytochemistry for the marker proteins S-100, glial fibrillary acidic protein, and p75 nerve growth factor receptor. Moreover, baculovirus-infected Schwann cells are capable of differentiating in vitro and express the P0 myelination marker. However, transcripts for several immediate-early viral genes also accumulate in readily detectable levels in the transduced cells. This transcriptional activity raises concerns regarding the long-term safety of baculovirus vectors for gene therapy applications. Potential approaches for overcoming the identified problem are discussed.
Improving the Oxidation Resistance and Electrical Properties of Ferritic Stainless Steels for Application in SOFC Interconnects (2015)

The paper presents the results of cyclic oxidation studies performed for two ferritic stainless steels: Crofer 22 APU and H25T. The surface of the steels was coated with particles of oxides of the following active elements: yttrium, cerium, samarium, and gadolinium. Two coating methods were used: electrolysis and dip-coating. In addition, yttrium ion implantation was carried out for the purpose of reference. Cyclic oxidation tests were carried out for ca. 1200 h in air at 900 °C. It was determined that particles of oxides of active elements reduce the rate of oxidation, improve the adhesion of the Cr2O3 scale to the substrate, and decrease area specific resistance.
Over-hydration detection in brain by magnetic induction spectroscopy (2010)

Detection and continuous monitoring of edema in the brain in early stages is useful for assessment of medical condition and treatment. We have proposed a solution in which the bulk measurements of the tissue electrical properties to detect edema or in general accumulation of fluids are made through measurement of the magnetic induction phase shift between applied and measured currents at different frequencies (Magnetic Induction Spectroscopy; MIS). Magnetic Resonant Imaging (MRI) has been characterized because its capability to detect different levels of brain tissue hydration by differences in diffusion-weighted (DW) sequences and it's involve apparent diffusion coefficient (ADC). The objective of this study was to explore the viability to use measurements of the bulk tissue electrical properties to detect edema or in general accumulation of fluids by MIS. We have induced a transitory and generalized tissue over-hydration condition in ten volunteers ingesting 1.5 to 2 liters of water in ten minutes. Basal and over-hydration conditions were monitored by MIS and MRI. Changes in the inductive phase shift at certain frequencies were consistent with changes in the brain tissue hydration level observed by DW-ADC. The results suggest that MIS has the potential to detect pathologies associated to changes in the content of fluids in brain tissue such as edema and hematomas.
Highly efficient organic light-emitting diodes with metal/fullerene anode (2006)

Metal/fullerene bilayers have been studied as hole injection electrodes for use in organic light-emitting diodes (OLEDs). In the case of a simple emission zone structure, it is found that OLEDs with the Au∕C60 anodes have much lower (∼10V) driving voltages and much higher current efficiencies (five times higher) than OLEDs with a simple Au anode. This anode structure was found to be applicable for all types of light-emitting structures including fluorescent and phosphorescent dye-doped systems. The formation of a primary bond at the Au∕C60 interface is explained as the major cause for efficient hole injection from Au to C60. The hole transfer barrier between C60 and the adjacent hole transport layer is also found critical in selecting suitable matching materials to achieve highly efficient OLEDs.
Development of a sheathless CE‐ESI‐MS interface (2018)

A sheath-flow interface is the most common ionization technique in CE-ESI-MS. However, this interface dilutes the analytes with the sheath liquid and decreases the sensitivity. In this study, we developed a sheathless CE-MS interface to improve sensitivity. The interface was fabricated by making a small crack approximately 2 cm from the end of a capillary column fixed on a plastic plate, and then covering the crack with a dialysis membrane to prevent metabolite loss during separation. A voltage for CE separation was applied between the capillary inlet and the buffer reservoir. Under optimum conditions, 52 cationic metabolite standards were separated and selectively detected using MS. With a pressure injection of 5 kPa for 15 s (ca. 1.4 nL), the detection limits for the tested compounds were between 0.06 and 1.7 μmol/L (S/N = 3). The method was applied to analysis of cationic metabolites extracted from a small number (12 000) of cancer cells, and the number of peaks detected was about 2.5 times higher than when using conventional sheath-flow CE-MS. Because the interface is easy to construct, it is cost-effective and can be adapted to any commercially available capillaries. This method is a powerful new tool for highly sensitive CE-MS-based metabolomic analysis.
dbSUPER: a database of super-enhancers in mouse and human genome (2015)

Super-enhancers are clusters of transcriptional enhancers that drive cell-type-specific gene expression and are crucial to cell identity. Many disease-associated sequence variations are enriched in super-enhancer regions of disease-relevant cell types. Thus, super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance. However, a centralized resource to integrate all these findings is not currently available. We developed dbSUPER (http://bioinfo.au.tsinghua.edu.cn/dbsuper/), the first integrated and interactive database of super-enhancers, with the primary goal of providing a resource for assistance in further studies related to transcriptional control of cell identity and disease. dbSUPER provides a responsive and user-friendly web interface to facilitate efficient and comprehensive search and browsing. The data can be easily sent to Galaxy instances, GREAT and Cistrome web-servers for downstream analysis, and can also be visualized in the UCSC genome browser where custom tracks can be added automatically. The data can be downloaded and exported in variety of formats. Furthermore, dbSUPER lists genes associated with super-enhancers and also links to external databases such as GeneCards, UniProt and Entrez. dbSUPER also provides an overlap analysis tool to annotate user-defined regions. We believe dbSUPER is a valuable resource for the biology and genetic research communities.
Computer Reconstruction Techniques in Compound Scan Pulse-Echo Imaging (1981)

Reconstruction techniques currently used for forming pulse-echo compound scan images are reviewed. A computer based system for acquiring and storing the pulse-echo data in video line-mode form, (i.e. the detected echo waveform and deflection co-ordinates for each transmitted pulse) is described in both its hardware and software aspects. The performance of peak detected, minimum detected, integrated and averaged reconstruction on point targets is illustrated and discussed. The properties of the various techniques in reconstructing clinical data obtained from the pregnant uterus, abdomen and breast are outlined and future clinical applications suggested.
Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling (2006)

TopBP1-like proteins, which include Xenopus laevis Xmus101, are required for DNA replication and have been linked to replication checkpoint control. A direct role for TopBP1/Mus101 in checkpoint control has been difficult to prove, however, because of the requirement for replication in generating the DNA structures that activate the checkpoint. Checkpoint activation occurs in X. laevis egg extracts upon addition of an oligonucleotide duplex (AT70). We show that AT70 bypasses the requirement for replication in checkpoint activation. We take advantage of this replication-independent checkpoint system to determine the role of Xmus101 in the checkpoint. We find that Xmus101 is essential for AT70-mediated checkpoint signaling and that it functions to promote phosphorylation of Claspin bound Chk1 by the ataxia-telangiectasia and Rad-3-related (ATR) protein kinase. We also identify a separation-of-function mutant of Xmus101. In extracts expressing this mutant, replication of sperm chromatin occurs normally; however, the checkpoint response to stalled replication forks fails. These data demonstrate that Xmus101 functions directly during signal relay from ATR to Chk1.
New drugs for the treatment of schizophrenic patients (1995)

Conventional neuroleptics are widely accepted as being effective against the positive symptoms of schizophrenia, but do not benefit all patients. Furthermore, they are relatively ineffective against negative symptoms and cognitive disorders, and most have unpleasant side effect profiles. New strategies for treating schizophrenia include the development of dopamine antagonists with high selectivity for different subtypes of dopamine receptors, dopamine partial agonists, antagonists at different serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, drugs with mixed pharmacological profiles and drugs which modify transmission via amino acids or peptides in the brain. The prospect is that some of these strategies will lead to the introduction of new drugs and that some of these will become the standards against which future drugs will be compared. The search for new drugs and their use in clinical practice will also lead to developments in our knowledge and understanding of schizophrenia.
Centerline Placement and Alignment of Anisotropic Nanotubes in High Aspect Ratio Cylindrical Droplets of Nanometer Diameter (2008)

High aspect ratio cylindrical droplets of carbon-nanotube solutions present interesting hydrodynamic flow patterns during evaporation, where particles are aligned and positioned. The flow inside droplets with diameters <1000 nm positions all the nanotubes along the droplet centerline with 95% precision, while droplets with diameters >3µm align the nanotubes along the droplet edges during evaporation. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.