gebhart/patrepeval huggingface dataset:
Corona charging of polymers: recent advances on constant current charging (1999)

This paper contains a brief overview on the recent developments of corona charging of polymers, with emphasis on the current corona triode. This latter method, which has been successfully applied to several types of polymer, is a legacy from Prof. Bernhard Gross' work in São Carlos, Brazil. Following a short introduction to corona charging, the experimental setups are described, especially with regard to the advantages in the constant current method. A few examples are given of the use of the constant current corona triode in the investigation of electrical properties of nonpolar and ferroeleectric polymers. The application of corona charging to pole nonlinear optic (NLO) polymers is discussed, including the perspectives for the constant current charging method for the NLO field.
Compressive light-field microscopy for 3D neural activity recording (2016)

Understanding the mechanisms of perception, cognition, and behavior requires instruments that are capable of recording and controlling the electrical activity of many neurons simultaneously and at high speeds. All-optical approaches are particularly promising since they are minimally invasive and potentially scalable to experiments interrogating thousands or millions of neurons. Conventional light-field microscopy provides a single-shot 3D fluorescence capture method with good light efficiency and fast speed, but suffers from low spatial resolution and significant image degradation due to scattering in deep layers of brain tissue. Here, we propose a new compressive light-field microscopy method to address both problems, offering a path toward measurement of individual neuron activity across large volumes of tissue. The technique relies on spatial and temporal sparsity of fluorescence signals, allowing one to identify and localize each neuron in a 3D volume, with scattering and aberration effects naturally included and without ever reconstructing a volume image. Experimental results on live zebrafish track the activity of an estimated 800+ neural structures at 100 Hz sampling rate.
Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase (1998)

Promoters PA and PBin the UNG gene and alternative splicing are utilized to generate nuclear (UNG2) and mitochondrial (UNG1) forms of human uracil-DNA glycosylase. We have found the highest levels of UNG1 mRNA in skeletal muscle, heart and testis and the highest UNG2 mRNA levels in testis, placenta, colon, small intestine and thymus, all of which contain proliferating cells. In synchronized HaCaT cells mRNAs for both forms increased in late G1/early S phase, accompanied by a 4- to 5-fold increase in enzyme activity. A combination of mutational analysis and transient transfection demonstrated that an E2F-1/DP-1-Rb complex is a strong negative regulator of both promoters, whereas 'free' E2F-1/DP-1 is a weak positive regulator, although a consensus element for E2F binding is only present in PB. These results indicate a central role for an E2F-DP-1-Rb complex in cell cycle regulation of UNG proteins. Sp1 and c-Myc binding elements close to transcription start areas were positive regulators of both promoters, however, whereas overexpression in HeLa cells of Sp1 stimulated both promoters, c-Myc and c-Myc/Max overexpression had a suppressive effect. CCAAT elements were negative regulators of PB, but positive regulators of PA. These results demonstrate differential expression of mRNAs for UNG1 and UNG2 in human tissues.
Leukemia inhibitory factor induces sympathetic sprouting in intact dorsal root ganglia in the adult rat <i>in vivo</i> (1998)

1. The role of the cytokine leukemia inhibitory factor (LIF) in axotomy-induced sprouting of postganglionic sympathetic fibres into the dorsal root ganglia was examined in the adult rat. 2. Immunocytochemistry was used to study the distribution and density of tyrosine hydroxylase-immunoreactive (TH-IR) fibres within the lumbar dorsal root ganglia and lumbar spinal nerves 14 days following continuous intrathecal infusion of LIF (0.33 mg ml-1), or 14 days following unilateral peripheral nerve axotomy. 3. In LIF-treated animals, numerous pericellular TH-IR basket-like structures were observed surrounding sensory neurones, which were absent from controls. 4. The number of TH-IR fibres within the L3, L4 and L5 spinal nerves was significantly higher in LIF-treated animals than in control or saline-treated animals (P < 0.01, Student's t test). 5. Unilateral ligation of the L4 spinal nerve or unilateral sciatic nerve ligation was also associated with the formation of TH-IR baskets around sensory neurons and a significant increase in the number of TH-IR fibres within the lumbar spinal nerves (P < 0.01, Student's t test). 6. The percentage of neurones surrounded by TH-IR baskets within the L3 and L4 dorsal root ganglia following sciatic axotomy was significantly reduced in animals treated continuously for 2 weeks with a monoclonal antibody against the LIF receptor motif, gp130 (0.833 mg ml-1) (P < 0.05, Mann-Whitney U test). Antibody treatment did not reduce the axotomy-induced increase in TH-IR fibres within lumbar spinal nerves. 7. These results demonstrate that exogenous application of the axotomy-associated cytokine LIF is associated with sprouting of uninjured postganglionic sympathetic neurones around sensory neurones within the dorsal root ganglion. It is likely that increased LIF expression following peripheral axotomy plays an important role in the novel sympathetic sprouting observed within sensory ganglia following peripheral nerve injury.
Semantic Information Extraction for Improved Word Embeddings (2015)

Word embeddings have recently proven useful in a number of different applications that deal with natural language. Such embeddings succinctly reflect semantic similarities between words based on their sentence-internal contexts in large corpora. In this paper, we show that information extraction techniques provide valuable additional evidence of semantic relationships that can be exploited when producing word embeddings. We propose a joint model to train word embeddings both on regular context information and on more explicit semantic extractions. The word vectors obtained from such an augmented joint training show improved results on word similarity tasks, suggesting that they can be useful in applications that involve word meanings.
High efficiency and low torque ripple control of permanent magnet synchronous motor based on the current tracking vector of electromotive force (2002)

This paper describes the zero-torque ripple and minimum copper loss control of a permanent magnet synchronous motor with distorted electromotive force using a general three-phase inverter and d-q coordinates.
Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells (2011)

Misregulation of a pluripotency-associated transcription factor network in adult tissues is associated with the expansion of rare, highly malignant tumor-initiating stem cells (TISCs) through poorly understood mechanisms. We demonstrate that robust and selective expression of the receptor for the adipocyte-derived peptide hormone leptin (OB-R) is a characteristic feature of TISCs and of a broad array of embryonic and induced pluripotent stem cells and is mediated directly by the core pluripotency-associated transcription factors OCT4 and SOX2. TISCs exhibit sensitized responses to leptin, including the phosphorylation and activation of the pluripotency-associated oncogene STAT3 and induction of Oct4 and Sox2, thereby establishing a self-reinforcing signaling module. Exposure of cultured mouse embryonic stem cells to leptin sustains pluripotency in the absence of leukemia inhibitory factor. By implanting TISCs into leptin-deficient ob/ob mice or into comparably overweight Lepr(db/db) mice that produce leptin, we provide evidence of a central role for the leptin-TISC-signaling axis in promoting obesity-induced tumor growth. Differential responses to extrinsic, adipocyte-derived cues may promote the expansion of tumor cell subpopulations and contribute to oncogenesis.
A Modified Friedlander Condensation for the Synthesis of 3-Hydroxyquinoline-2-carboxylates (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Modified Friedlander Condensation for the Synthesis of 3-Hydroxyquinoline-2-carboxylatesDale L. Boger and J.-H. ChenCite this: J. Org. Chem. 1995, 60, 22, 7369–7371Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/jo00127a055https://doi.org/10.1021/jo00127a055research-articleACS PublicationsRequest reuse permissionsArticle Views805Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
The effects of clozapine on neurocognition: an overview. (1994)

Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. Its effects on cognitive function in schizophrenia are more variable. Clozapine appears to have a salutary effect on some aspects of attention, response speed, and fluency, whereas it appears to have a mild but adverse effect on visual memory and some executive functions. This profile may be related to the affinity of clozapine for dopaminergic type I and muscarinic receptors and relative lack of affinity for dopaminergic type II receptors.
Fusion of Global and Local Motion Estimation Using Foreground Objects for Distributed Video Coding (2014)

The side information (SI) in Distributed Video Coding (DVC) is estimated using the available decoded frames and exploited for the decoding and reconstruction of other frames. The quality of the SI has a strong impact on the performance of DVC. Here, we propose a new approach that combines both global and local SI to improve coding performance. Since the background pixels in a frame are assigned to global estimation and the foreground objects to local estimation, one needs to estimate foreground objects in the SI using the backward and forward foreground objects, the background pixels are directly taken from the global SI. Specifically, elastic curves and local motion compensation are used to generate the foreground objects masks in the SI. Experimental results show that, as far as the rate-distortion performance is concerned, the proposed approach can achieve a PSNR improvement of up to 1.39 dB for a group of picture (GOP) size of 2, and up to 4.73 dB for larger GOP sizes, with respect to the reference DISCOVER codec.
Potential Applications of the da Vinci Minimally Invasive Surgical Robotic System in Otolaryngology (2005)

Anatomic constraints and instrumentation design characteristics have limited the exploitation of endoscopic surgery in otolaryngology. The move toward less invasive and less morbid procedures has paved the way for the development and application of robotic and computer-assisted systems in surgery. Surgical robotics allows for the use of new instrumentation in our field. We review the operative advantages, limitations, and possible surgical applications of the da Vinci Surgical System in otolaryngology. In the laboratory setting, we explored the setup and use of the da Vinci system in porcine and cadaveric head and neck airway models; the setup was configuredfor optimal airway surgery. Endoscopic cautery, manipulation, and suturing of supraglottic tissues were performed in both the porcine and cadaveric models. We found that the da Vinci system provided the advantages of the lower morbidity associated with endoscopic surgery, more freedom of movement, and three-dimensional open surgical viewing. We also observed that the system has several limitations to use in otolaryngology.
Electrochromic semiconductor nanocrystal films (2002)

Electron injection into nanocrystal thin films is reversibly controlled by applying an electrochemical potential. Complete bleach of the visible interband transition and strong midinfrared intraband absorption are observed upon electron injection into the nanocrystal films. Quenching of the photoluminescence of the nanocrystal film is also observed.
The 2′- <i>O</i> -methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition (2012)

Foreign RNA serves as pathogen-associated molecular pattern (PAMP) and is a potent immune stimulator for innate immune receptors. However, the role of single bacterial RNA species in immune activation has not been characterized in detail. We analyzed the immunostimulatory potential of transfer RNA (tRNA) from different bacteria. Interestingly, bacterial tRNA induced type I interferon (IFN) and inflammatory cytokines in mouse dendritic cells (DCs) and human peripheral blood mononuclear cells (PBMCs). Cytokine production was TLR7 dependent because TLR7-deficient mouse DCs did not respond and TLR7 inhibitory oligonucleotides inhibited tRNA-mediated activation. However, not all bacterial tRNA induced IFN-α because tRNA from Escherichia coli Nissle 1917 and Thermus thermophilus were non-immunostimulatory. Of note, tRNA from an E. coli knockout strain for tRNA (Gm18)-2'-O-methyltransferase (trmH) regained immunostimulatory potential. Additionally, in vitro methylation of this immunostimulatory Gm18-negative tRNA with recombinant trmH from T. thermophilus abolished its IFN-α inducing potential. More importantly, Gm18-modified tRNA acted as TLR7 antagonist and blocked IFN-α induction of influenza A virus-infected PBMCs.
Overexpression of IGFBP5, but not IGFBP3, Correlates with the Histologic Grade of Human Diffuse Glioma: A Tissue Microarray and Immunohistochemical Study (2006)

Insulin-like growth factor binding proteins (IGFBPs) comprise a family of proteins that bind and regulate the functions of IGFs. One of the IGFBPs, IGFBP2, has recently been shown to be overexpressed in glioblastoma. Overexpression of IGFBP2 contributes to the invasiveness of glioblastoma and correlates with histologic grade and survival in patients with diffuse gliomas, suggesting that IGFBP2 expression may contribute to the glioma formation and/or progression. The expression of other IGFBP family members in gliomas has, however, not been examined in detail. This study was designed to evaluate the expression of IGFBP3 and IGFBP5 in diffuse gliomas using immunohistochemistry applied to a tissue array constructed from 259 gliomas, including ten gliosarcomas. Expression of IGFBP5 correlated significantly with glioma histologic grade. 83% (58/70) of glioblastomas (WHO Grade IV) were positive for IGFBP5, which was significantly higher than WHO Grade III gliomas (41%, 41/101) or WHO Grade II gliomas (18%, 13/72) (p<0.001). In contrast, IGFBP3 was expressed in 17%, 23%, and 17% of WHO Grade IV, Grade III, and Grade II gliomas, respectively (p>0.05). There was no significant difference in IGFBP3 expression among different grades of glioma. Our study thus demonstrates that the expression of IGFBP5, but not IGFBP3, increases with glioma anaplastic progression. The strong correlation between overexpression of IGFBP5 and histologic grade suggests that, in addition to IGFBP2, IGFBP5 may also play a role in glioma progression.
Efficient Homogeneous Catalytic Hydrogenation of Esters to Alcohols (2006)

Mit offenen Armen: Die durch einen Ruthenium-PNN-Komplex (siehe Schema) katalysierte Hydrierung von Estern verläuft unter Neutralbedingungen und in hoher Ausbeute. Der analoge PNP-Komplex ist weniger aktiv. Der vorgeschlagene Mechanismus beruht auf dem hemilabilen Charakter des PNN-Liganden, der die Bildung einer freien Koordinationsstelle durch Dekoordinieren des CH2NEt2-Arms ermöglicht. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z503771_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dynamic Head Characterization in the Presence of Reader Nonlinear Distortion (2004)

Nonlinear response in magnetostrictive sensors significantly affects the spin-stand parametric measurements used to characterize writer and reader performance of recording heads. A simple production level test defined as the nonlinear distortion (NLD) ratio was used to quantify the degree of reader nonlinearity. A positive NLD value represents the presence of reader distortion while a value of zero represents no distortion. On a large population of heads tested, the median NLD value was 0.25, which is equivalent to an amplitude loss of 10% for an isolated pulse due to reader saturation. A detailed analysis of the measured data on nonlinear transition shift, partial erasure, and PW50 of these production heads show that greater than 50% of the measured variance is due to readback nonlinear distortion rather than true performance variation of the device.
A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells (2016)

Successful bone tissue engineering requires at the minimum sufficient osteoblast progenitors, efficient osteoinductive factors, and biocompatible scaffolding materials. We previously demonstrated that bone morphogenetic protein 9 (BMP9) is one of the most potent factors in inducing osteogenic differentiation of mesenchymal stem cells (MSCs). Here, we investigated the potential use of a biodegradable citrate-based thermosensitive macromolecule, poly(polyethyleneglycol citrate-co-N-isopropylacrylamide) (PPCN) mixed with gelatin (PPCNG) as a scaffold for the delivery of BMP9-stimulated MSCs to promote localized bone formation. The addition of gelatin to PPCN effectively enhanced the cell adhesion and survival properties of MSCs entrapped within the gel in 3D culture. Using the BMP9-transduced MSC line immortalized mouse embryonic fibroblasts (iMEFs), we found that PPCNG facilitated BMP9-induced osteogenic differentiation of iMEFs in vivo and promoted the formation of well-ossified and vascularized trabecular bone-like structures in a mouse model of ectopic bone formation. Histologic evaluation revealed that vascularization of the bony masses retrieved from the iMEFs + PPCNG group was significantly more pronounced than that of the direct cell injection group. Accordingly, vascular endothelial growth factor (VEGF) expression was shown to be significantly higher in the bony masses recovered from the iMEFs + PPCNG group. Taken together, our results suggest that PPCNG may serve as a novel biodegradable and injectable scaffold and carrier for gene and cell-based bone tissue engineering.
Air analysis using tenax collection with jet-separator enrichment and ion trap mass spectrometric analysis (1996)

A dual adsorbent trap inlet system has been developed for an ion trap mass spectrometer (ITMS) to provide a rapid and sensitive system for screening of volatile organic compounds in air. The system employs three stages of concentration: preconcentration on an adsorbent Tenax trap, focusing in a cryogenic collection trap, and jet separator enrichment immediately prior to analysis by ITMS. Ten minute integrated samples are collected and analyzed immediately. The detection limit is 0. 9 parts-per-trillion by volume (pptrv) based on toluene as the analyte, and the reproducibility is 2% or better. Ambient air was analyzed for toluene on April 4, 1996 in Los Alamos, New Mexico, and concentrations ranged from 11-158 pptrv.
The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium (2013)

Amyloid hypothesis of Alzheimer's disease (AD) has recently been challenged by the increasing evidence for the role of vascular and hemostatic components that impair oxygen delivery to the brain. One such component is fibrin clots, which, when they become resistant to thrombolysis, can cause chronic inflammation. It is not known, however, why some cerebral thrombi are resistant to the fibrinolytic degradation, whereas fibrin clots formed at the site of vessel wall injuries are completely, although gradually, removed to ensure proper wound healing. This phenomenon can now be explained in terms of the iron-induced free radicals that generate fibrin-like polymers remarkably resistant to the proteolytic degradation. It should be noted that similar insoluble deposits are present in AD brains in the form of aggregates with Abeta peptides that are resistant to fibrinolytic degradation. In addition, iron-induced fibrin fibers can irreversibly trap red blood cells (RBCs) and in this way obstruct oxygen delivery to the brain and induce chronic hypoxia that may contribute to AD. The RBC-fibrin aggregates can be disaggregated by magnesium ions and can also be prevented by certain polyphenols that are known to have beneficial effects in AD. In conclusion, we argue that AD can be prevented by: (1) limiting the dietary supply of trivalent iron contained in red and processed meat; (2) increasing the intake of chlorophyll-derived magnesium; and (3) consumption of foods rich in polyphenolic substances and certain aliphatic and aromatic unsaturated compounds. These dietary components are present in the Mediterranean diet known to be associated with the lower incidence of AD and other degenerative diseases.
Anisotropic Properties of Superconducting Single Crystals (La<sub>1-x</sub>Sr<sub>x</sub>)<sub>2</sub>CuO<sub>4</sub> and Ba<sub>2</sub>YCu<sub>3</sub>O<sub>7+y</sub> (1987)

Resistivity and the second critical field H c2 have been measured for superconducting (La 1-x Sr x ) 2 CuO 4 and Ba 2 Cu 3 O 7+y single crystals grown from the melt. The H c2 along the basal plane is estimated to be larger than that along the c-axis by a factor of more than 5. These anisotropy due to crystallographic structure is briefly discussed.
Digital Rights Management System Based on PKCS#12 (2010)

Most of the existing Digital Rights Management(DRM) system can not meet the requirement of security and flexibility in digital media application.Aiming at this problem,this paper proposes a DRM system based on PKCS#12.It designs the system architecture and the security protocol of user registration,certificate issuing,encrypted digital content distribution,authorized license delivery,authentication and decryption,etc.With the security of PKCS#12 and the security of the designed protocols,the proposed system provides the secure storage and transfer of certificate and private key,lets users participate in system applications through different devices,and prevents digital rights from illegal sharing.