gebhart/patrepeval huggingface dataset:
A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic CMOS SoC for Real-Time Epileptic Seizure Control (2013)

An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wireless power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30- μA stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18- μm CMOS and occupies 13.47 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy (> 92%) within 0.8 s.
Experiments Involving a Microwave Beam to Power and Position a Helicopter (1969)

This paper describes two different experiments involving a microwavebeam and a helicopter. The first experiment utilized a CW microwavebeam to supply a small helicopter with all of the power that it neededfor its propulsion. The second experiment utilized an unmodulated CW microwave beam for supplying a position reference to the helicopterer with respect to roll, pitch, yaw, and horizontal translation. Thesecond experiment also involved the construction of a fully articulatedhelicopter and a complete control system carried on board theli-helicopter. The paper also attempts to relate the small scale experimentsand the present state of component technology to practical, full scalemicrowave-powered helicopter systems that can operate at altitudesof up to 50 000 feet.
Green and Blue Monochromatic Lights Promote Growth and Development of Broilers Via Stimulating Testosterone Secretion and Myofiber Growth (2008)

Methods of light treatment such as light schedule, intensity or illuminance, and color are important factors that influence avian productivity. Therefore, artificial illumination has been widely used in modern poultry husbandry. Although progress had been made in understanding of the effects of light schedule and intensity on avian growth, effects of light color on avian growth are not clear. In this study, 276 male Arbor Acres broilers were reared under white, red, green, and blue lights from light-emitting diode lamps as light sources. Broilers’ growth and productive performance were increased under green light during the early period (0 to 26 d of age) or blue light during the later period (27 to 49 d of age). Furthermore, both blue and green lights were more effective to stimulate testosterone secretion and myofiber growth that led to increased body growth. These results indicate that light-emitting diode lamps have value in the modern broiler husbandry.
Yeast infection of burns (2001)

In a prospective study, 132 patients were investigated for yeast infection of burn wounds. Ten patients (7.6%) were infected with Candida species. All patients with yeast infections were also infected with bacteria with the exception of one patient who was infected with Candida tropicalis alone. The predominant yeast recovered was Candida krusei. Yeast infection was found to be more common in the younger age group. The isolation of a Candida species alone from one patient and Candida isolation from patients with sepsis in burn wounds indicate a significant role for yeasts in the production of infection in burn wounds. Therefore, special cultures for yeasts are recommended for all cases of burn wound infection.
Personalized tag recommendation using graph-based ranking on multi-type interrelated objects (2009)

Social tagging is becoming increasingly popular in many Web 2.0 applications where users can annotate resources (e.g. Web pages) with arbitrary keywords (i.e. tags). A tag recommendation module can assist users in tagging process by suggesting relevant tags to them. It can also be directly used to expand the set of tags annotating a resource. The benefits are twofold: improving user experience and enriching the index of resources. However, the former one is not emphasized in previous studies, though a lot of work has reported that different users may describe the same concept in different ways. We address the problem of personalized tag recommendation for text documents. In particular, we model personalized tag recommendation as a "query and ranking" problem and propose a novel graph-based ranking algorithm for interrelated multi-type objects. When a user issues a tagging request, both the document and the user are treated as a part of the query. Tags are then ranked by our graph-based ranking algorithm which takes into consideration both relevance to the document and preference of the user. Finally, the top ranked tags are presented to the user as suggestions. Experiments on a large-scale tagging data set collected from Del.icio.us have demonstrated that our proposed algorithm significantly outperforms algorithms which fail to consider the diversity of different users' interests.
Performance-Complexity Tradeoffs of Concatenated FEC for Higher-Order Modulation (2020)

Multilevel coding (MLC) is compared with bit-interleaved coded modulation (BICM) from a performance-versus-complexity standpoint. In both approaches, complexity-optimized error-reducing low-density parity-check inner codes are designed for concatenation with an outer hard-decision code, for various modulation orders. The codes are designed to achieve various points on the Pareto frontier characterizing the performance-complexity tradeoff. Computer simulations of the resulting codes reveal that MLC not only provides significant advantages compared with BICM, but also outperforms several existing MLC and BICM proposals. At 25% overhead, MLC provides a net coding gain of up to 12.8 dB with 16-QAM (1.0 dB from the constrained Shannon limit), a net coding gain of up to 13.6 dB with 64-QAM (1.2 dB from the constrained Shannon limit), and a net coding gain of up to 14 dB with 256-QAM (1.65 dB from the constrained Shannon limit), all with reasonable decoding complexity.
Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors (2017)

Described herein are the discovery and structure-activity relationship (SAR) studies of the third-generation 4-H heteroaryldihydropyrimidines (4-H HAPs) featuring the introduction of a C6 carboxyl group as novel HBV capsid inhibitors. This new series of 4-H HAPs showed improved anti-HBV activity and better drug-like properties compared to the first- and second-generation 4-H HAPs. X-ray crystallographic study of analogue 12 (HAP_R01) with Cp149 Y132A mutant hexamer clearly elucidated the role of C6 carboxyl group played for the increased binding affinity, which formed strong hydrogen bonding interactions with capsid protein and coordinated waters. The representative analogue 10 (HAP_R10) was extensively characterized in vitro (ADMET) and in vivo (mouse PK and PD) and subsequently selected for further development as oral anti-HBV infection agent.
Aminoacylation of Synthetic DNAs Corresponding to <i>Escherichia coli</i> Phenylalanine and Lysine tRNAs (1988)

Synthetic DNA oligomers (tDNAs) corresponding to Escherichia coli tRNA(Phe) or tRNA(Lys) have been synthesized with either deoxythymidine (dT) or deoxyuridine (dU) substituted in the positions occupied by ribouridine or its derivatives. The tDNAs inhibited the aminoacylation of their respective tRNAs with their cognate amino acids, but not the aminoacylation of tRNA(Leu) with Leu. In the presence of aminoacyl-tRNA synthetase, species of both a tDNA(Phe) synthesized with a 3' terminal riboadenosine and a tDNA(Lys) containing only deoxynucleotides could be aminoacylated with the appropriate amino acids, although the Michaelis constant Km and observed maximal rate Vmax values for aminoacylation were increased by three- to fourfold and decreased by two- to threefold, respectively. The aminoacylation of synthetic tDNAs demonstrates that the ribose backbone of a tRNA is not absolutely required for tRNA aminoacylation.
FGF21 as Modulator of Metabolism in Health and Disease (2019)

Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic pathways. FGF21 is expressed in several metabolically active organs and interacts with different tissues. The FGF21 function is complicated and well debated due to its different sites of production and actions. Striated muscles are plastic tissues that undergo adaptive changes within their structural and functional properties in order to meet their different stresses, recently, they have been found to be an important source of FGF21. The FGF21 expression and secretion from skeletal muscles happen in both mouse and in humans during their different physiological and pathological conditions, including exercise and mitochondrial dysfunction. In this review, we will discuss the recent findings that identify FG21 as beneficial and/or detrimental cytokine interacting as an autocrine or endocrine in order to modulate cellular function, metabolism, and senescence.
Forschungsschiff METEOR Reise Nr. 6, Forschungsprogramm ATLANTIK 87/88 (1988)

1
Form Rolling of Helical Gears with Small Number of Teeth and Large Helix Angle (2012)

A number of reduction gear units with small electric motors as power sources are used in automobiles. Smaller units with a low energy consumption are required for future electric vehicles. Although worm gears are widely used in units with a large gear ratio, their efficiency is too low. Therefore, only large motors can be applied in cases where a large torque is required. Even cylindrical gear pairs and/or face gears with a large gear ratio could enable reduction gear units to have a higher efficiency and a lower energy consumption. For this purpose, helical gears with a small number of teeth and a large helix angle are necessary. In the present paper, cold form rolling for forming such gears was proposed. The tooth form accuracy of form-rolled gears was compared with those cut using a hob. Furthermore, the efficiency and service life of the gears were examined. The results show that cold form rolling can be used to form helical gears with a small number of teeth and a large helix angle.
pH-Responsive Thin Film Membranes from Poly(2-vinylpyridine):  Water Vapor-Induced Formation of a Microporous Structure (2007)

We report the fabrication of microporous thin film membranes with two-dimensionally arranged submicron pores whose size can be varied by changing pH of aqueous medium. A solution containing poly(2-vinylpyridine) partially quaternized with 1,4-diiodobutane (qP2VP) and unreacted 1,4-diodobutane (DIB) was used for the formation and deposition of the membranes on solid substrates. The membranes were spin-coated onto solid substrates in a controlled humid environment. The presence of water vapor in air was found to be a necessary condition for the pore formation. We studied the influence of relative humidity on the membrane morphology and proposed a mechanism of pore formation. Cross-linking the qP2VP membranes with DIB made them insoluble (stable) in organic solvents and acidic water. The cross-linked membranes demonstrated pH-dependent swelling, which had a strong influence on the pore size.
The Binding of Sulfate Anions by Guanidinium Receptors is Entropy-Driven (1998)

Clear trends in the molecular recognition of guest species by artificial hosts in solution are often observed by intrinsic enthalpy-entropy compensation, which requires the dissection of these free-energy components. Contrary to common belief, it is not the enthalpic electrostatic attraction that makes guanidinium hosts such as 1 strong binders for sulfate anions. Isothermal titration calorimetry has now allowed this molecular recognition to be characterized as an entropy-driven association.
Subarachnoid spread of epidural local anaesthetic following dural puncture (1988)

Summary A case is described of an extensive block and hypotension which occurred after inadvertent dural puncture and subsequent epidural injection of bupivacaine. The subarachnoid spread of solution from the extradural space was confirmed radiologically.
Modern intraoperative imaging modalities for the vascular neurosurgeon treating intracerebral hemorrhage (2013)

This paper reviews the current intraoperative imaging tools that are available to assist neurosurgeons in the treatment of intracerebral hemorrhage (ICH). This review shares the authors' experience with each modality and discusses the advantages, potential limitations, and disadvantages of each. Surgery for ICH is directed at blood clot removal, reduction of intracranial pressure, and minimization of secondary damage associated with hematoma breakdown products. For effective occlusion and safe obliteration of vascular anomalies associated with ICH, vascular neurosurgeons today require a thorough understanding of the various intraoperative imaging modalities available for obtaining real-time information. Use of one or more of these modalities may improve the surgeon's confidence during the procedure, the patient's safety during surgery, and surgical outcome. The modern techniques discussed include 1) indocyanine green-based video angiography, which provides real-time information based on high-quality images showing the residual filling of vascular pathological entities and the patency of blood vessels of any size in the surgical field; and 2) intraoperative angiography, which remains the gold standard intraoperative diagnostic test in the surgical management of cerebral aneurysms and arteriovenous malformations. Hybrid procedures, providing multimodality image-guided surgeries and combining endovascular with microsurgical strategies within the same surgical session, have become feasible and safe. Microdoppler is a safe, noninvasive, and reliable technique for evaluation of hemodynamics of vessels in the surgical field, with the advantage of ease of use. Intraoperative MRI provides an effective navigation tool for cavernoma surgery, in addition to assessing the extent of resection during the procedure. Intraoperative CT scanning has the advantage of very high sensitivity to acute bleeding, thereby assisting in the confirmation of the extent of hematoma evacuation and the extent of vascular anomaly resection. Intraoperative ultrasound aids navigation and evacuation assessment during intracerebral hematoma evacuation surgeries. It supports the concept of minimally invasive surgery and has undergone extensive development in recent years, with the quality of ultrasound imaging having improved considerably. Image-guided therapy, combined with modern intraoperative imaging modalities, has changed the fundamentals of conventional vascular neurosurgery by presenting real-time visualization of both normal tissue and pathological entities. These imaging techniques are important adjuncts to the surgeon's standard surgical armamentarium. Familiarity with these imaging modalities may help the surgeon complete procedures with improved safety, efficiency, and clinical outcome.
Estrogen-mediated Regulation of Igf1 Transcription and Uterine Growth Involves Direct Binding of Estrogen Receptor α to Estrogen-responsive Elements (2009)

Estrogen enables uterine proliferation, which depends on synthesis of the IGF1 growth factor. This proliferation and IGF1 synthesis requires the estrogen receptor (ER), which binds directly to target DNA sequences (estrogen-responsive elements or EREs), or interacts with other transcription factors, such as AP1, to impact transcription. We observe neither uterine growth nor an increase in Igf1 transcript in a mouse with a DNA-binding mutated ER alpha (KIKO), indicating that both Igf1 regulation and uterine proliferation require the DNA binding function of the ER. We identified several potential EREs in the Igf1 gene, and chromatin immunoprecipitation analysis revealed ER alpha binding to these EREs in wild type but not KIKO chromatin. STAT5 is also reported to regulate Igf1; uterine Stat5a transcript is increased by estradiol (E(2)), but not in KIKO or alpha ERKO uteri, indicating ER alpha- and ERE-dependent regulation. ER alpha binds to a potential Stat5a ERE. We hypothesize that E(2) increases Stat5a transcript through ERE binding; that ER alpha, either alone or together with STAT5, then acts to increase Igf1 transcription; and that the resulting lack of IGF1 impairs KIKO uterine growth. Treatment with exogenous IGF1, alone or in combination with E(2), induces proliferation in wild type but not KIKO uteri, indicating that IGF1 replacement does not rescue the KIKO proliferative response. Together, these observations suggest in contrast to previous in vitro studies of IGF-1 regulation involving AP1 motifs that direct ER alpha-DNA interaction is required to increase Igf1 transcription. Additionally, full ER alpha function is needed to mediate other cellular signals of the growth factor for uterine growth.
백색 스탠다드 장미 "White Day" 육성 (2010)

A new standard rose cultivar ‘White Day’ was bred from the cross between white standard cultivar ‘Athena’ and white standard cultivar ‘Tineke’at the National Institute of Horticultural and Herbal Science. The cross was made in 1998 and ‘White Day’was finally selected in 2002 after investigating its characteristics for three years from 2000 to 2002 (UPOV standards). ‘White Day’, a white standard cultivar grows vigorously and has good flower shape. The major characteristics of this cultivar are 106.3 stems/m2/year in yield, 68.6 cm in length of cut flower, 14.3 cm in flower diameter, 93.5 in petal number per stem, and 13.4 days in vase life. This cultivar can be propagated by both cutting and grafting. The consumer’s preference of this cultivar is relatively higher than that of control cultivar, ‘Tineke’.
Home care comes full circle. (1994)

Health care practices in the US are changing as managed care, government regulations, and patient preferences alter care delivery. Home care will play a major role in these changes if the industry takes advantage of this trend toward a more flexible, independent patient model--returning health care to its origins as it completes the journey from home to institutions...and back again.
High-speed optoelectronic gallium arsenide switch triggered by mode-locked laser pulses (1983)

Abstract The performance of an optoelectronic semiconductor switch triggered by mode-locked laser pulses is investigated theoretically. The interaction of the laser light with the semiconductor is represented by a non-linear partial differential equation which is solved by computational means. The mode-locked lasers which are considered to trigger the switch are the alexandrite laser (0·765 μm) and the dye laser (0·61 μm). The semiconducting material considered in the interaction is semi-insulating gallium arsenide which is specially compensated to have intrinsic properties (particularly a very high initial resistivity). The results show that the switch can have a response time of the order of several picoseconds, an ‘off’ time of the order of a few nanoseconds and a repetition rate approaching 1 GHz. Additional informationNotes on contributorsM. S. DEMOKAN Presently at University of London, King's College, Department of Electronic and Electrical Engineering, Strand, London WC2R 2LS, and, Imperial College of Science and Technology, Optics Section, London SW7 2BZ, U.K.
High performance automatic gain control circuit using a S/H peak-detector for ASK receiver (2003)

A high performance automatic gain control (AGC) circuit is proposed in this paper. The proposed AGC incorporates a modified sample and hold peak-detector. Circuit operation of this new peak-detector demonstrates superior performance to the conventional one, by keeping and tracking the peak of the input signal at the same time. In addition, the design complexity of the proposed AGC is reduced in both the low pass filter and the demodulator due to the modified peak-detector. Based on simulation results, the complete AGC loop shows very satisfactory circuit operation. Therefore, it is suitable for high performance communication applications such as ASK (amplitude shift keyed) receivers.
J. de Launay, J. Offergeld, Belgen en bezetters. Het dagelijkse leven tijdens de bezetting 1940-1945; P. Louyet, België in de tweede wereldoorlog, IV, Het verzet; J. Gérard, Chronique de la Régence, 1944-1950 (1987)

Het is ook in deze verhouding dat de Duitsers eigenlijk nimmer echt vat kregen op de Nederlandse ondernemers, noch vr noch tijdens de bezetting. Wat dit betreft kwamen de
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining (2010)

Given its significant role in the maintenance of genomic stability, histone methylation has been postulated to regulate DNA repair. Histone methylation mediates localization of 53BP1 to a DNA double-strand break (DSB) during homologous recombination repair, but a role in DSB repair by nonhomologous end-joining (NHEJ) has not been defined. By screening for histone methylation after DSB induction by ionizing radiation we found that generation of dimethyl histone H3 lysine 36 (H3K36me2) was the major event. Using a novel human cell system that rapidly generates a single defined DSB in the vast majority of cells, we found that the DNA repair protein Metnase (also SETMAR), which has a SET histone methylase domain, localized to an induced DSB and directly mediated the formation of H3K36me2 near the induced DSB. This dimethylation of H3K36 improved the association of early DNA repair components, including NBS1 and Ku70, with the induced DSB, and enhanced DSB repair. In addition, expression of JHDM1a (an H3K36me2 demethylase) or histone H3 in which K36 was mutated to A36 or R36 to prevent H3K36me2 formation decreased the association of early NHEJ repair components with an induced DSB and decreased DSB repair. Thus, these experiments define a histone methylation event that enhances DNA DSB repair by NHEJ.
Virus-expressed, recombinant single-chain antibody blocks sporozoite infection of salivary glands in Plasmodium gallinaceum-infected Aedes aegypti. (2000)

Transgenic mosquitoes resistant to malaria parasites are being developed to test the hypothesis that they may be used to control disease transmission. We have developed an effector portion of an antiparasite gene that can be used to test malaria resistance in transgenic mosquitoes. Mouse monoclonal antibodies that recognize the circumsporozoite protein of Plasmodium gallinaceum can block sporozoite invasion of Aedes aegypti salivary glands. An anti-circumsporozoite monoclonal antibody, N2H6D5, whose corresponding heavy- and light-chain gene variable regions were engineered as a single-chain antibody construct, binds to P. gallinaceum sporozoites and prevents infection of Ae. aegypti salivary glands when expressed from a Sindbis virus. Mean intensities of sporozoite infections of salivary glands in mosquitoes expressing N2scFv were reduced as much as 99.9% when compared to controls.