gebhart/patrepeval huggingface dataset:
Clinical supervision: an interdisciplinary review of literature with implications for reflective practice in social work (2009)

This review explores the ways in which being a clinical supervisor and supervisee is represented in the interdisciplinary literature with implications for reflective practice in social work. Clinical supervision (CS), which is considered as ‘effective’, is described in the literature as occurring with a trained and experienced supervisor who can provide expertise and the continuity of a clinical supervisory relationship in which there are opportunities for engaging in a sustained on‐the job reflection. From this dialogue, insights into practice can grow and flourish. However, this kind of supervisory relationship is an ideal rather than the reality of many practice environments. Developing different modes of relating in the practice environment where trust and respect can exist and differences of power, and culture acknowledged in terms of gender, class, race, ethnicity and sexual orientation, is a current challenge for clinical supervisors and supervisees in social work. Models of CS drawn from transactional analysis (TA), Relational‐Cultural therapy and Gestalt models in psychotherapy offer new understandings of the relationship needed in CS for it to be seen as a ‘safe place’ to reflect upon practice.
Synthesis and facile end‐group quantification of functionalized PEG azides (2016)

Azido-functionalized poly(ethylene glycol) (PEG) derivatives are finding ever-increasing applications in the areas of conjugation chemistry and targeted drug delivery by their judicious incorporation into nanoparticle-forming polymeric systems. Quantification of azide incorporation into such PEG polymers is essential to their effective use. <sup>1</sup>H Nuclear Magnetic Resonance (NMR) analysis offers the simplest approach; however, the relevant adjacent azide-bearing methylene protons are often obscured by the PEG manifold signals. This study describes the synthesis of 1,2,3-triazole adducts from their corresponding PEG azides via a convenient, mild click reaction, which facilitates straightforward NMR-based quantitative end-group analysis.This method was found to be compatible with many examples of bifunctional azido PEGs with molecular weights ranging from 2 to 18 kDa bearing a variety of functional groups. © 2016 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. <b>2016</b>, <i>54</i>, 2888-2895.
Polyvalent Marek's disease vaccines: Safety, efficacy and protective synergism in chickens with maternal antibodies<sup>1</sup> (1984)

Three Marek's disease (MD) vaccines were evaluated for safety and protective efficacy in chickens with maternal antibodies against serotype 1, 2 and 3 MD viruses and in chickens with no maternal antibodies. The vaccines were: (1) Md11/75C, an attenuated serotype 1 MD virus, (2) a trivalent mixture of MD virus strains Md11/75C and SB-1, and turkey herpesvirus (HVT) strain FC 126, and (3) bivalent mixtures of these three viruses. These vaccines were compared with HVT or SB-1 vaccines in some trials. None of the vaccines was pathogenic or immunodepressive in susceptible chickens with or without maternal antibodies. No interference with in vivo HVT replication by additional viral components was noted, although some interference was demonstrated in vitro. Md11/75C replicated to limited titres in vivo and did not spread by contact, however, it acquired mild pathogenicity upon serial back-passage. Although Md11/75C provided good protection against highly virulent MD viruses in chickens without maternal antibodies, it was poorly protective in chickens with homologous maternal antibodies, and appeared more susceptible to in vivo neutralisation than did SB-1 or HVT. The trivalent vaccine, in contrast, was highly efficacious against very virulent MD virus challenge, even in chickens with maternal antibodies of all three serotypes, and was significantly more effective than monovalent vaccines. A bivalent vaccine composed of SB-1 and HVT was superior to the other two bivalent combinations of the three viruses. Protective synergism among all three vaccine viruses was confirmed. The efficacy of HVT was enhanced by as little as 80 PFU of SB-1, and even fractional doses of HVT and SB-1 together were superior to full doses of HVT alone.
A detergent-activated tyrosinase from Xenopus laevis. II. Detergent activation and binding. (1985)

Tyrosinase purified from Xenopus is enzymatically inactive in aqueous buffers but is activated for both of its substrates by exposure to a variety of anionic detergents. Cationic and nonionic detergents, as well as a variety of other agents are ineffective. This stimulation by detergents is observed at all stages of the purification (Wittenberg, C., and Triplett, E. L. (1985) J. Biol. Chem. 260, 12535-12541). Sodium dodecyl sulfate (NaDodSO4) is the most effective activator, and it was chosen for further characterization. Activation of both activities by NaDodSO4 is rapid and concentration dependent, resulting in maximal activity after 4 min at 1 mM NaDodSO4. NaDodSO4 treatment also results in both long and short term stabilization of the enzyme. The activation and stabilization are separable but stoichiometrically related. Both effects occur well below the critical micelle concentration suggesting that the interaction of NaDodSO4 monomers with the enzyme is involved in these processes. In support of this suggestion, the enzyme is shown to bind NaDodSO4 with high affinity, as determined by equilibrium dialysis. The isotherm for this binding correlates well with the requirement of NaDodSO4 for both activation and stabilization. All three effects are observable at 3 X 10(-5) M NaDodSO4 in the presence of 0.1 M sodium chloride. Activation and stabilization are maximal at 6 X 10(-4) M NaDodSO4, the critical micelle concentration of NaDodSO4 under these conditions.
Stable porphyrin vesicles formed in non-aqueous media and dried to produce hollow shells (2009)

Stable vesicles of an amphiphilic manganese complex of 5,10,15,20-tetrakis-4-oxy(2-stearic acid)phenylporphyrin [Mn(iii)TPP(COOH)] were formed in non-aqueous solution (CHCl(3) + CH(3)OH, 4 : 1 v/v); the vesicles can be dried to produce hollow shells.
Design considerations for high-frequency crystal oscillators digitally trimmable to sub-ppm accuracy (1997)

The current consumption of crystal oscillators is usually determined by the steady-state amplitude requirement, rather than the minimum transconductance for oscillation to exist, In a bipolar implementation transconductance is proportional to current, so that current consumption scales with frequency and load capacitance in the same way as transconductance. In a complementary metal-oxide-semiconductor (CMOS) implementation, current scales as the square of transconductance. It is therefore important to distinguish current from transconductance in power estimation for high frequency oscillators. Analytical expressions relating current to steady-state amplitude are used in this paper to estimate the minimum power required for a crystal oscillator at a given frequency. A 78 MHz crystal oscillator is described, which forms part of a regulated system in a pager where the oscillation frequency is controlled digitally to sub-ppm accuracy. The oscillator can be pulled from /spl plusmn/65 ppm to the required frequency with 0.2 ppm accuracy, with a maximum current consumption of 197 /spl mu/A. The circuit has been fabricated in a 1-/spl mu/m CMOS technology. The measured phase noise is -113 dBc/Hz at 300 Hz offset.
High power diode laser arrays (1992)

Recent progress in the development of high-power diode laser arrays for solid-state laser pumping is detailed. Advances in available wavelength, efficiency, temperature of operation, duty cycle of operation, and peak and average power levels or densities are described. A packaging architecture capable of addressing the broadest range of pump applications and designs in an economic manner is defined, and a range of such package designs is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Neutrophil Function: From Mechanisms to Disease (2012)

Neutrophils are the most abundant white blood cells in circulation, and patients with congenital neutrophil deficiencies suffer from severe infections that are often fatal, underscoring the importance of these cells in immune defense. In spite of neutrophils' relevance in immunity, research on these cells has been hampered by their experimentally intractable nature. Here, we present a survey of basic neutrophil biology, with an emphasis on examples that highlight the function of neutrophils not only as professional killers, but also as instructors of the immune system in the context of infection and inflammatory disease. We focus on emerging issues in the field of neutrophil biology, address questions in this area that remain unanswered, and critically examine the experimental basis for common assumptions found in neutrophil literature.
Photoconductivity and Crystal Imperfections in Cadmium Sulfide Crystals. Part I. Effect of Impurities (1955)

The conductivity and photosensitivity of cadmium sulfide crystals can be controlled by the incorporation of suitable impurities. The conductivity and photosensitivity are increased by the incorporation of a halide or a trivalent cation, and decreased by the incorporation of copper or silver. A possible mechanism by which such impurities may produce the observed effects on the photoconductivity is presented.
Characterization of Varicella-Zoster Virus Gene 21 and 29 Proteins in Infected Cells (2002)

Varicella-zoster virus (VZV) transcription is limited in latently infected human ganglia. Note that much of the transcriptional capacity of the virus genome has not been analyzed in detail; to date, only VZV genes mapping to open reading frames (ORFs) 4, 21, 29, 62, and 63 have been detected. ORF 62 encodes the major immediate-early virus transcription transactivator IE62, ORF 29 encodes the major virus DNA binding protein, and ORF 21 encodes a protein associated with the developing virus nucleocapsid. We analyzed the cellular location of proteins encoded by ORF 21 (21p) and ORF 29 (29p), their phosphorylation state during productive infection, and their ability form a protein-protein complex. The locations of both 21p and 29p within infected cells mimic those of their herpes simplex virus type 1 (HSV-1) homologues (UL37 and ICP8); however, unlike these homologues, 21p is not phosphorylated and neither 21p nor 29p exhibits a protein-protein interaction. Transient transfection assays to determine the effect of 21p and 29p on transcription from VZV gene 20, 21, 28, and 29 promoters revealed no significant activation of transcription by 21p or 29p from any of the VZV gene promoters tested, and 21p did not significantly modulate the ability of IE62 to activate gene transcription. A modest increase in IE62-induced activation of gene 28 and 29 promoters was seen in the presence of 29p; however, IE62-induced activation of gene 28 and 29 promoters was reduced in the presence of 21p. A Saccharomyces cerevisiae two-hybrid analysis of 21p indicated that the protein can activate transcription when tethered within a responsive promoter. Together, the data reveal that while VZV gene 21 and HSV-1 UL37 share homology at the nucleic acid level, these proteins differ functionally.
Principles Of Modelling (2001)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsRhys DavidRhys is currently a Principal Safety & Reliability Consultant in the Government and Defence Business Unit of TA Group Ltd. He is the Project Manager for a number of Contracts helping organisations to establish and improve their Safety Management Systems and conducting System Safety Assessments. Rhys has used modelling for R&M, Safety, logistics and cost studies in the power, process and defence industries and is part of the development team for TA Group's RAM4 and RAMP modelling packages. He previously worked as a design engineer for the UK Atomic Energy Authority.
Heilmittelchemische Studien in der heterocyclischen Reihe. 34. Mitteilung. Pyrazolo‐pyrimidine V. Eine neue Synthese von Pyrazolo[3,4‐d]pyrimidinen mit coronarerweiternden Eigenschaften (1962)

Abstract Condensation of 3‐amino‐4‐carbethoxy‐pyrazoles with nitriles led to a new synthesis of 6‐C‐substituted pyrazolo[3,4‐d]pyrimidines and 6‐amino‐pyrazolo‐[3,4‐b]pyridines. The structure of the new derivatives was established by independent syntheses. The pyrazolo‐pyrimidines can be cleaved with phosphoric acid to 3‐amino‐pyrazole‐4‐carboxamide derivatives. Many of the new pyrazolo‐pyrimidines show an increase of coronary flow.
Spectral analysis of Hall-effect thruster plasma oscillations based on the empirical mode decomposition (2005)

Hall-effect thruster plasma oscillations recorded by means of probes located at the channel exit are analyzed using the empirical mode decomposition (EMD) method. This self-adaptive technique permits to decompose a nonstationary signal into a set of intrinsic modes, and acts as a very efficient filter allowing to separate contributions of different underlying physical mechanisms. Applying the Hilbert transform to the whole set of modes allows to identify peculiar events and to assign them a range of instantaneous frequency and power. In addition to 25kHz breathing-type oscillations which are unambiguously identified, the EMD approach confirms the existence of oscillations with instantaneous frequencies in the range of 100–500kHz typical for ion transit-time oscillations. Modeling of high-frequency modes (ν∼10MHz) resulting from EMD of measured wave forms supports the idea that high-frequency plasma oscillations originate from electron-density perturbations propagating azimuthally with the electron drift velocity.
Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature (2015)

Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and kill bacteria but also injure host tissue. Here we show that during a bloodstream infection with methicillin-resistant Staphylococcus aureus, the majority of bacteria are sequestered immediately by hepatic Kupffer cells, resulting in transient increases in liver enzymes, focal ischaemic areas and a robust neutrophil infiltration into the liver. The neutrophils release NETs into the liver vasculature, which remain anchored to the vascular wall via von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity. Importantly, DNase although very effective at DNA removal, and somewhat effective at inhibiting NE proteolytic activity, fails to remove the majority of histones from the vessel wall and only partly reduces injury. By contrast, inhibition of NET production as modelled by PAD4-deficiency, or prevention of NET formation and proteolytic activity as modelled in NE(-/-) mice prevent collateral host tissue damage.
Design of a silicon avalanche photodiode pixel with integrated laser diode using back-illuminated crystallographically etched silicon-on-sapphire with monolithically integrated microlens for dual-mode passive and active imaging arrays (2010)

There is a growing need in scientific research applications for dual-mode, passive and active 2D and 3D LADAR imaging methods. To fill this need, an advanced back-illuminated silicon avalanche photodiode (APD) design is presented using a novel silicon-on-sapphire substrate incorporating a crystalline aluminum nitride (AlN) antireflective layer between the silicon and R-plane sapphire. This allows integration of a high quantum efficiency silicon APD with a gallium nitride (GaN) laser diode in each pixel. The pixel design enables single photon sensitive, solid-state focal plane arrays (FPAs) with wide dynamic range, supporting passive and active imaging capability in a single FPA. When (100) silicon is properly etched with TMAH solution, square based pyramidal frustum or mesa arrays result with the four mesa sidewalls of the APD formed by (111) silicon planes that intersect the (100) planes at a crystallographic angle, φ c = 54.7°. The APD device is fabricated in the mesa using conventional silicon processing technology. The GaN laser diode is fabricated by epitaxial growth inside of an inverted, etched cavity in the silicon mesa. Microlenses are fabricated in the thinned, and AR-coated sapphire substrate. The APDs share a common, front-side anode contact, and laser diodes share a common cathode. A low resistance (Al) or (Cu) metal anode grid fills the space between pixels and also inhibits optical crosstalk. SOS-APD arrays are flip-chip bump-bonded to CMOS readout ICs to produce hybrid FPAs. The square 27 μm emitter-detector pixel achieves SNR > 1 in active detection mode for Lambert surfaces at 1,000 meters.
Compact and efficient multipass Ti:sapphire system for femtosecond chirped-pulse amplification at the terawatt level (1993)

We have developed efficient multipass Ti:sapphire amplifiers for femtosecond chirped-pulse amplification. With only two of these devices we get an amplification factor of 10(8), which corresponds to a peak power of ~0.5 TW after compression. We present a detailed analysis of such a system and its advantages in terms of its high quantum yield (0.3), flexibility, optical quality, and potential for tunability.
Interactive Problem Solving Using Logo (2014)

This book is unique in that its stress is not on the mastery of a programming language, but on the importance and value of interactive problem solving. The authors focus on several specific interest worlds: mathematics, computer science, artificial intelligence, linguistics, and games; however, their approach can serve as a model that may be applied easily to other fields as well. Those who are interested in symbolic computing will find that Interactive Problem Solving Using LOGO provides a gentle introduction from which one may move on to other, more advanced computational frameworks or more formal analysis. What is of primary importance, however, is the text's ability -- through its presentation of rich, open-ended problems -- to effectively cultivate crucial cognitive skills.
Cycle-slips in 100G DP-QPSK Transmission Systems (2012)

We present real-time measurements of the cycle-slip probabilities of a 100G DP-QPSK transceiver using a Viterbi-and-Viterbi carrier recovery. ASE and non-linear phase noise generated Poisson distributed slip events with mean probabilities between 10−12 to 10−3.
A fuzzy approach to low level sensor fusion with limited system knowledge (2010)

When facing the need to perform low-level sensor fusion with only very limited knowledge available one has to come up with an alternative to the well known and proven Kalman filter. A very interesting candidate for such applications is the so called fuzzy (or soft) voter. This algorithm makes use of fuzzy logic principles to fuse signals in an efficient way and provides a figure of merit as well as sensor monitoring capabilities with very moderate demand for computation performance and memory. In this paper a computational efficient alternative implementation of soft voting for embedded applications is described. Furthermore, its performance is examined using scenarios typical to harsh operations environments using simulation.
Compact high-quality CdSe/CdS core/shell nanocrystals with narrow emission linewidths and suppressed blinking (2013)

High particle uniformity, high photoluminescence quantum yields, narrow and symmetric emission spectral lineshapes and minimal single-dot emission intermittency (known as blinking) have been recognized as universal requirements for the successful use of colloidal quantum dots in nearly all optical applications. However, synthesizing samples that simultaneously meet all these four criteria has proven challenging. Here, we report the synthesis of such high-quality CdSe–CdS core–shell quantum dots in an optimized process that maintains a slow growth rate of the shell through the use of octanethiol and cadmium oleate as precursors. In contrast with previous observations, single-dot blinking is significantly suppressed with only a relatively thin shell. Furthermore, we demonstrate the elimination of the ensemble luminescence photodarkening that is an intrinsic consequence of quantum dot blinking statistical ageing. Furthermore, the small size and high photoluminescence quantum yields of these novel quantum dots render them superior in vivo imaging agents compared with conventional quantum dots. We anticipate these quantum dots will also result in significant improvement in the performance of quantum dots in other applications such as solid-state lighting and illumination.
Application of Electron Microscopy to Human Otopathology: Ultrastructural Findings in Neural Presbycusis, Meniere's Disease and Usher's Syndrome (1988)

Electron microscopy of well-preserved postmortem specimens of the inner ear of the human can provide significant details concerning human otopathology not discernible by light microscopy. As examples, ultrastructural findings in neural presbycusis, Meniere's disease and Usher's syndrome are presented. In all three pathologies there is evidence of neuronal degeneration, particularly within the dendritic arborization of the spiral ganglion, which is not observable by light microscopy.
Latent phenotypes pervade gene regulatory circuits (2014)

Our observations suggest that latent phenotypes are pervasive in regulatory circuits, and may thus be an important source of evolutionary adaptations and innovations involving gene regulation.
Chemical and Engineering News (1945)

RETURN TO ISSUEPREVNewsNEXTChemical and Engineering NewsWALTER J. MURPHYCite this: Chem. Eng. News 1945, 23, 4, 368–369Publication Date (Print):February 25, 1945Publication History Published online4 November 2010Published inissue 25 February 1945https://pubs.acs.org/doi/10.1021/cen-v023n004.p368https://doi.org/10.1021/cen-v023n004.p368newsACS PublicationsCopyright © 1945 AMERICAN CHEMICAL SOCIETYArticle Views22Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Chemical engineering and industrial chemistry Get e-Alerts