gebhart/patrepeval huggingface dataset:
Cytogenetic studies of prostatic cancer. (1991)

In this study we wanted to find out if the size or position of the constitutive C-band positive heterochromatin regions of chromosomes was associated with variation in prostatic cancer predisposition. We found no such association when comparing the whole patient group with healthy controls, but younger (less than 70 years) cancer patients had significantly higher frequencies of large C-bands on chromosomes 1 and 16 than older patients (greater than 70 years). This could indicate a possible relationship between the amount of constitutive heterochromatin on chromosomes 1 and 16 and susceptibility to early development of prostatic cancer. The purpose of this study was to examine if the number of AgNORs was higher in malignant than normal or hyperplastic prostatic tissue, and if the number of AgNORs increased with increasing grade of malignancy. More AgNOR dots were found in the prostatic adenocarcinomas (average 24/cell) than in the normal and hyperplastic prostates (average 13/cell). The poorly differentiated adenocarcinomas had more AgNORs than the moderately and well differentiated cancers. The data indicate that analysis of silver staining-positive material in intact interphase cells may help distinguish between benign and malignant prostatic tumors, and between highly malignant and low malignant carcinomas. The purpose was to find consistent and specific chromosome abnormalities in primary prostatic adenocarcinomas. Because then existing techniques for culturing human neoplastic prostatic tissue rarely yielded sufficiant epithelial cell growth and mitosis we decided to modify these techniques. Tumor samples from 82 patients were processed for short-term culture. Cytogenetic analysis was successful in 57 tumors, 42 of which were cultured after September 1, 1988, when the modifications were implemented. Thirteen of the 15 primary tumor samples that contained clonal karyotypic abnormalities were processed after September 1, 1988. Loss of chromosomal material from 7q, 8p, and 10q, and structural aberrations of bands 7q22 and 10q24 were the most common aberrations found. From these data it may be inferred that both loss of tumor suppressor genes and activation of oncogenes located in the breakpoint regions may be important pathogenetic events in the development or progression of prostatic adenocarcinoma. In this study we wanted to examine the clinical implications of karyotypic abnormalities. We found a significant difference in survival after diagnosis and surgery between patients whose tumors had clonal structural abnormalities (A), patients whose tumors had nonclonal changes (NA), and patients whose tumors had normal karyotypes only (N).(ABSTRACT TRUNCATED AT 400 WORDS)
Early Fibular Bypass Procedures (Tibiofibular Synostosis) for Massive Bone Loss in War Injuries (1979)

The techniques of fibular bypass grafting for massive tibial bone loss have been well described over the past 50 years. These techniques have generally been used as salvage procedures in post-traumatic civilian patients with chronic sepsis, or for congenital pseudoarthrosis. We present the experience of the Orthopaedic Department of the Hadassah University Hospital in successfully treating massive tibial bone loss by early fibular bypass grafting in four war injuries, where such definitive procedures would have been avoided in the past.
Analysis of Inflow Control Devices (2009)

Abstract Inflow Control Devices (IDCs) were initially developed to avoid water coning problems in long horizontal wells. They have been used with success the past 15 years. There are, however, issues that needs to be resolved. A pressure drop model of the ICD is presented herein. The physical model of the ICD consists of pressure drop equations from the reservoir, through the screen, through the flow conduit, through the ICD nozzle and into the production tubing, and, pressure drop through the lower completion system. Evaluation of the model shows that for current commercial tools, turbulent flow through the ICD dominates the pressure drop, leading to a density controlled flow. This is fortunate as density varies much less than viscosity over the production life of a field. Due to the inherent non-linear nature of a production system, the pressure drop versus flow rate will vary with degree of depletion. An ICD may be optimal initially, but not when the reservoir pressure is depleted. This paper also presents a new designer IDC concept which maintains constant flow regardless of the degree of field depletion. It is based on a hydraulic feedback principle, and ensures controlled flow throughout the life of the oil field.
Investigation of a high Tc piezoelectric system: (1−x)Bi(Mg1/2Ti1/2)O3–(x)PbTiO3 (2004)

(1−x) Bi(Mg 1/2 Ti 1/2 ) O 3 –x PbTiO 3 polycrystalline ceramics were investigated for potential as high-temperature piezoelectric materials. A morphotropic phase boundary (MPB) between tetragonal (T) and rhombohedral (R) ferroelectric (FE) phases, which exhibited enhanced piezoelectric activity and a ferroelectric–paraelectric phase transition at 478 °C was observed at x≈0.37. Electron diffraction patterns (x⩽0.37) contained discrete superlattice reflections at 12{hkl} positions arising from antiphase rotations of the O octahedra, consistent with R3c space group symmetry. These reflections were diffuse at the MPB (x=0.38) and absent in the T phase (x=0.5). In the unpoled state, FE R (x=0.35) ceramics revealed a polar microdomain structure whereas the T phase (x=0.5) contained classic {110} twin domain boundaries. However, poled R samples underwent a field-induced transformation to an aligned domain structure with {110} twin boundaries similar to those in the T phase. Correlations are made between structure and properties for these piezoelectric materials.
Practical Implications of Malolactic Fermentation: A Review (1985)

Malolactic fermentation (MLF) is discussed in terms of its effect on wine quality and methods currently available for its control. Benefits of MLF include the lowering of acidity in high acid wines, enhancement of sensory characteristics through bacterial activity, and enhanced microbiological stability. Undesirable effects include the excessive reduction in acidity of high pH wines leading to risk of spoilage, production of undesirable flavors, color changes, and formation of amines. Methods of control involve stimulation of indigenous flora, inoculation of bacteria (either pure cultures or from wines already undergoing MLF), use of immobilized bacterial cells or enzymes, and practical measures to inhibit bacterial growth.
Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels (1998)

A system for on-line measurements of trace components with concentrations as low as a few pptv has been developed on the basis of proton transfer reactions. Medical applications by means of breath analysis allow the monitoring of metabolic processes in the human body, and examples of food research include investigations of volatile organic compound (VOC) emissions from fruit, coffee and meat. Investigations of VOC emissions from decaying biomatter and on-line monitoring of the diurnal variations of VOCs in ambient air are typical examples of environmental applications.
Data management and analysis for high-throughput DNA sequencing projects (1995)

The rapid advances in molecular biology have begun to shift many of the bottlenecks in genome research from the laboratory to the data analysis facility. The pace at which this has occurred creates a situation in which software development always has to catch up with the flow of data. Since such large-scale processes were not anticipated, the analysis infrastructure has not been fully established. Furthermore, most systems that have been built were designed by the biologists who collected the data. More recently, computer scientists, mathematicians, and engineers have taken an interest in this problem. This has had a positive effect, since it has created a tight synergy between the informatics and the biology. Several principles affected the design of the system developed at TIGR. Each of the sample preparation, sequencing, and analysis steps had to be managed, scheduled, and tracked. This information had to be made readily available to those who needed it for carrying out their tasks. Different skill levels of the users had to be taken into account. The degree of human intervention at each step had to be evaluated and built into the design. A mixed processing environment of Macintosh and Unix platforms had to be integrated. Most importantly, the system had to save time, reduce error, and ensure uniformity of the analysis and quality of the results. In the authors' experience, the tools they have built work well because of their early decisions as to which systems to use for development. The authors settled on a robust relational database management system (Sybase) and a portable development environment (C, C++).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
39. The formation of organo-metalloidal and similar compounds by micro-organisms. Part VII. Dimethyl telluride (1939)

M. L. Bird and F. Challenger, J. Chem. Soc., 1939, 163 DOI: 10.1039/JR9390000163
Micro-compression: a novel technique for the nondestructive assessment of local bone failure (1998)

Many bones within the axial and appendicular skeleton are subjected to repetitive, cyclic loading during the course of ordinary daily activities. If this repetitive loading is of sufficient magnitude or duration, fatigue failure of the bone tissue may result. In clinical orthopedics, trabecular fatigue fractures are observed as compressive stress fractures in the proximal femur, vertebrae, calcaneus and tibia, and are often preceded by buckling and bending of microstructural elements. However, the relative importance of bone density and architecture in the etiology of these fractures is poorly understood. The aim of the study was to investigate failure mechanisms of 3D trabecular bone using micro-computed tomography (microCT). Because of its nondestructive nature, microCT represents an ideal approach for performing not only static measurements of bone architecture but also dynamic measurements of failure initiation and propagation as well as damage accumulation. For the purpose of the study, a novel micro-compression device was devised to measure loaded trabecular bone specimens directly in a micro-tomographic system. The measurement window in the device was made of a radiolucent, highly stiff plastic to enable X-rays to penetrate the material. The micro-compressor has an outer diameter of 19 mm and a total length of 65 mm. The internal load chamber fits wet or dry bone specimens with maximal diameters of 9 mm and maximal lengths of 22 mm. For the actual measurement, first, the unloaded bone is measured in the microCT. Second, a load-displacement curve is recorded where the load is measured with an integrated mini-button load cell and the displacement is computed directly from the microCT scout-view. For each load case, a 3D snap-shot of the structure under load is taken providing 34 microm nominal resolution. Initial measurements included specimens from bovine tibiae and whale spine to investigate the influence of the structure type on the failure mechanism. In a rod-like type of architecture as seen in the whale spine, structural failure was described by an initial buckling and bending of structural elements followed by a collapse of the overloaded trabeculae. In the more plate-like bovine tibial architecture, buckling and bending could not be observed. Failure rather seemed to occur instantaneously. In conclusion, micro-compression in combination with 3D microCT allows visualization of failure initiation and propagation and monitoring of damage accumulation in a nondestructive way. We expect these findings to improve our understanding of the relative importance of density, architecture and load in the etiology of spontaneous fractures of the hip and the spine. Eventually, this improved understanding may lead to more successful approaches to the prevention of age-related fractures.
Treatment of visceral leishmaniasis in HIV-infected patients: a randomized trial comparing meglumine antimoniate with amphotericin B (1999)

Treatment of VL with meglumine antimoniate or amphotericin B was shown to have similar efficacy and toxicity rates in Spanish HIV-infected patients. The differences in the toxicity patterns could be useful in choosing one of these agents as first-line treatment.
DynaFlow: a dynamic inter-organisational workflow management system (2006)

As the global marketplace becomes more and more competitive, business organisations often need to team up and operate as a virtual enterprise to utilise the best of their resources for achieving their common business goals. As the business environment of a virtual enterprise is highly dynamic, it is necessary to develop a workflow management technology that is capable of handling dynamic workflows across enterprise boundaries. This paper describes a Dynamic Workflow Model (DWM) and a dynamic workflow management system (DynaFlow) for modelling and controlling the execution of inter-organisational business processes. DWM enables the specification of dynamic properties associated with a business process model. It extends the underlying model of the WfMC's WPDL by adding connectors, events, triggers and rules as its modelling constructs. It also encapsulates activity definitions and allows web service (or e-service) requests to be included as a part of the activity specification. Using DWM as the underlying model, DynaFlow makes use of an Event-Trigger-Rule (ETR) server to trigger rules during the enactment of a workflow process to enforce business rules and policies and/or to modify the process model at run-time. A constraint-based, dynamic service binding mechanism is used to dynamically bind web service requests to web services that satisfy the requirements of the requests.
A protocol for user awareness on the World Wide Web (1996)

Article A protocol for user awareness on the World Wide Web Share on Authors: Kevin Palfreyman Lancaster University, Lancaster, LA1 4YR, UK. Lancaster University, Lancaster, LA1 4YR, UK.View Profile , Tom Rodden Lancaster University, Lancaster, LA1 4YR, UK. Lancaster University, Lancaster, LA1 4YR, UK.View Profile Authors Info & Claims CSCW '96: Proceedings of the 1996 ACM conference on Computer supported cooperative workNovember 1996 Pages 130–139https://doi.org/10.1145/240080.240236Online:16 November 1996Publication History 44citation728DownloadsMetricsTotal Citations44Total Downloads728Last 12 Months9Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Status of ISO standardization of ESD test of satellite solar array (2007)

Frequent satellite failures due to charging and arcing on solar array surface, there are strong demands for more thorough ElectroStatic Discharge (ESD) ground test before the launch. It is necessary to validate that a given solar array design can withstand repeated arcing in space before the launch. Test conditions, however, differ among countries, as there is no international standard to define the conditions. An international research project started in 2005 to establish International Standard Organization (ISO) standard on ESD test. In the first year, test coupons of the international round robin tests were produced and the preliminary experiments were carried out. In September 2006, the team members gathered at ONERA, Toulouse France. Demonstration experiments were carried out and in-depth discussion was done regarding the preliminary test results of KIT (Kyushu Institute of Technology). In November 2006, the First International Workshop on ISO Standardization of Electrostatic Discharge Test of Satellite Solar Array was held in Kitakyushu. The first version of the working draft of ISO document was discussed in the workshop and the participants agreed to seek the ISO standard by as early as Fall 2008.
Utilisation de la plate-forme Moodle en Français sur Objectif Spécifique : vers une meilleure compréhension de l'oral en cours à l'INSA de Toulouse (2010)

Après avoir surmonté mon premier réflexe qui était de « défendre » ce qui avait été fait lors du stage, j'ai tenté de mener une analyse pertinente éclairée par des recherches faites dans les domaines de l'enseignement-apprentissage concernés. Ces derniers sont ceux du Français sur Objectif Spécifique et des TICE puisque, lors de mon stage, ma tâche principale était de créer un espace d'e-learning sur la plate-forme Moodle avec un objectif bien précis : aider les étudiants non francophones de l'INSA de Toulouse à comprendre l'oral dans leurs cours scientifiques et techniques.
Secreted Frizzled Related Protein 4 Reduces Fibrosis Scar Size and Ameliorates Cardiac Function After Ischemic Injury (2010)

Expression of the Wnt modulator secreted frizzled related protein 4 (Sfrp4) is upregulated after heart ischemic injury. We show that intramuscular administration of recombinant Sfrp4 to rat heart ischemic injury and recanalization models prevents further deterioration of cardiac function after the ischemic injury. The effect of Sfrp4 persisted for at least 20 weeks when Sfrp4 was administered in a slow release system (Sfrp4-polyhedra) to both acute and subacute ischemic models. The histology of the dissected heart showed that the cardiac wall was thicker and the area of acellular scarring was smaller in Sfrp4-treated hearts than in controls. Increased amounts of both the inactive serine 9-phosphorylated form of glycogen synthase kinase (GSK)-3β and the active form of β-catenin were observed by immunohistology 3 days after lateral anterior descendant ligation in control, but not in Sfrp4-treated hearts. All together, we show that administration of Sfrp4 interferes with canonical Wnt signaling that could mediate the formation of acellular scar and consequently contributes to the prevention of aggravation of cardiac function.
Adoptive transfer of tumor infiltrating lymphocytes for metastatic cervical cancer (2013)

Meeting abstracts Adoptive T-cell therapies for cancer can induce tumor responses in patients with metastatic melanoma, synovial sarcoma, and B-cell malignancies. However, no cellular therapy has demonstrated activity in a common epithelial tumor. Adoptive transfer of tumor infiltrating lymphocytes
The <sup>1</sup>H and <sup>13</sup>C NMR spectra of an alternating ethene/maleic anhydride copolymer and the corresponding acid and sodium salt (1995)

Abstract The 1 H and 13 C NMR spectra of an alternating ethene/maleic anhydride copolymer and the corresponding acid and sodium salt were reinvestigated with regard to the signals depending on the configuration of the succinyl unit. From these assignments a 85/15 ratio of threo ‐and erythro ‐ succinyl configurations was determined. Threo ‐ and erythro ‐units are statistically distributed. Furthermore, signal splittings were observed due to microtacticity. Explanations are given for the signal fine structure. The polymer chain is atactic but a small degree of stereoregularity can be proved. T 1 values and nuclear Overhauser effect (NOE) factors were determined; they correspond to investigations on other polymers.
The Contribution of Repellent Soap to Malaria Control (1997)

A study about the acceptability, protective efficacy, effectiveness, and cost of a repellent soap containing 20% diethyltoluamide and 0.5% permethrin was carried out on the Pacific coast of Ecuador and Peru, where malaria is endemic and the transmission is seasonal. The malaria vectors were Anopheles albimanus, An. punctimacula, and An. pseudopunctipennis in Ecuador and An. albimanus in Peru. Comparing the hourly mosquito bites on human subjects with and without the protection of the repellent soap, it showed that inactive, protected subjects were bitten 94.2% less than unprotected controls 2 hr after application of the soap. This protective efficacy was reduced to 81% after 6 hr. In persons physically active for 3 hr after application, the efficacy of the soap was 67% in the fourth hour after application and 52% in the sixth hour after application. Sweating decreased the protective efficacy of the soap even more. In a community-based malaria control program, the soap was introduced by community health promoters. Acceptance was good when it was given free of charge but reduced dramatically when it was sold. People used the soap mainly because of the nuisance of mosquitoes. The application was generally done correctly. However, no significant impact on the incidence of malaria episodes could be shown when comparing intervention communities with control communities, either in Ecuador, where the proportion of Plasmodium falciparum cases was high, or in Peru, where P. vivax was the only species of Plasmodium seen. This can probably be explained by the limited use of soap and the shift of mosquito bites from users to nonusers of the repellent soap. The cost of a soap program would be $4.60 (USA) per person per year, which seems to be quite high in terms of cost of soap and its distribution related to people's low cash income. The implications of the introduction of repellent soap into a control program are discussed.
ChemInform Abstract: Supersonic Jet Spectroscopy of N‐(4‐Cyanophenyl)carbazole and Its Complexes (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hepatic Metastasis from Colorectal Cancer (2016)

The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs. Despite these improvements, the presence of metastasis, disease recurrence, and advanced local tumors continue to remain poor prognostic factors. Median survival without treatment is <8 months from the moment of its presentation, and a survival rate at 5 years of 11% is the best prognosis for those who present with local metastasis. Even in patients with limited metastatic disease, 5-year survival is exceptional. Patients with hepatic metastasis of colorectal cancer have a median survival of 5 to 20 months with no treatment. Approximately 20 to 30% of patients with colorectal metastasis have disease confined to the liver, and this can be managed with surgery. Modern surgical strategies at the main hepatobiliary centers have proved that hepatectomy of 70% of the liver can be performed, with a mortality rate of <5%. It is very important to have knowledge of predisposing factors, diagnostic methods, and treatment of hepatic metastasis. However, the establishment of newer, efficient, preventive screening programs for early diagnosis and adequate treatment is vital. <b>How to cite this article:</b> Valderrama-Treviño AI, Barrera-Mera B, Ceballos-Villalva JC, Montalvo-Javé EE. Hepatic Metastasis from Colorectal Cancer. Euroasian J Hepato-Gastroenterol 2017;7(2):166-175.