gebhart/patrepeval huggingface dataset:
Complexation of Triclopyr Butoxy Ethyl Ester with β‐Cyclodextrin (2006)

β‐cyclodextrin (β‐CD), a macro‐cyclic oligosaccharide exhibits the property of forming inclusion complexes with various molecules. These complexes display some improved properties of starting molecule such as, increase of aqueous solubility, improvement in stability as well as reduction of bad odor and/or toxicity of molecules. The formulation of an inclusion complex of β‐CD as the host molecule and triclopyr butoxy ethyl ester, a selective systemic herbicide, as guest molecule has been studied as an initial step towards the improvement in the conventional herbicide formulations. The interaction of triclopyr butoxy ethyl ester with β‐CD produced the formation of an inclusion complex. Three processing methods (kneading, co‐precipitation and co‐evaporation) were used to prepare solid inclusion complexes. X‐ray diffraction (XRD), differential scanning calorimetry (DSC) and ultra‐violet (UV) spectroscopy techniques were used to study the complexation of this herbicide. The objective of the present work was to study the complexation and enhanced aqueous solubility of triclopyr butoxy ethyl ester. Phase solubility study suggested the existence of a 1:1 complex between herbicide and β‐CD. XRD and DSC analysis indicated the existence of an inclusion complex of herbicide with β‐CD. Dissolution rate study was conducted so as to study dissolution properties of complexes. The dissolution rate of the complexed herbicide in aqueous media was considerably improved as compared with the uncomplexed herbicide. The study also attempts to compare the various methods of complex formation. The best results were obtained when inclusion complexes were prepared by co‐precipitation method. Findings of this paper will allow more rational applications of herbicide with increase in its efficiency.
FcγRI Coupling to Phospholipase D Initiates Sphingosine Kinase-mediated Calcium Mobilization and Vesicular Trafficking (1998)

Aggregation of receptors specific for the constant region of immunoglobulin G activates a repertoire of monocyte responses that can lead ultimately to targeted cell killing via antibody-directed cellular cytotoxicity. The high affinity receptor, FcgammaRI, contains no recognized signaling motif in its cytoplasmic tail but rather utilizes the gamma-chain of FcepsilonRI as an accessory molecule to recruit tyrosine kinases for signal transduction. We show here that, in a human monocytic cell line primed with interferon-gamma, FcgammaRI mobilizes intracellular calcium stores using a novel pathway that involves tyrosine kinase coupling to phospholipase D and resultant downstream activation of sphingosine kinase. Moreover, FcgammaRI is not coupled to phospholipase C; hence, calcium release from intracellular stores occurred in the absence of any measurable rise in inositol triphosphate. Finally, as this novel activation pathway is also shown to be responsible for mediating the vesicular trafficking of internalized immune complexes for degradation, it is likely to play a key role in controlling intracellular events triggered by FcgammaRI.
Tintinnids and other microzooplankton—seasonal distributions and relationships to resources and hydrography in a Maine estuary (1987)

Journal of Plankton Research , 9 , 65–77, 1987. In Table II on page 70 the number of Tintinnopsis minuta found at 0 m depth on 15 September 1981 should be 1200.
Detection of stair dimensions for the path planning of a bipedal robot (2002)

This paper deals with the detection of the characteristics of stairs, i.e. the number of steps, the step height and the step width for online path planning of a bipedal robot. For the construction of a multi-purpose, mobile platform for service robot applications with special respect to the human environment, a biped is more advantageous than a wheel based robot. In the framework of our studies, the bipedal robot BARt-UH has been built and walking as well as the climbing of stairs have been realized. The environment of the robot is assumed to be structured, consisting of flat surfaces and stairs, but not known in advance. Therefore, a state transition algorithm for intelligent path planning of the robot is suggested. Further, a stereo vision module with a line laser is considered, in order to detect the stair dimensions. The necessary information is extracted from the projection of the line laser onto the stairs. To achieve this, three algorithms were implemented and a comparative study was carried out.
File migration in the NCAR mass storage system (2003)

As of July 25, 1988, the mass storage system (MSS) at the National Center for Atmospheric Research (NCAR) contained 55.8 tb of user data in more than 291000 bitfiles averaging greater than 23 megabytes (MB) in size. The bulk of the data is housed in a (nonautomated) library of IBM 3480 tape cartridges, and the remainder resides temporarily on a disk farm of IBM 3380e disks. A discussion is presented of the strategy used in developing an effective management policy for the movement of files between the disk farm and tape library, the algorithms chosen, the mechanisms implemented for tuning those algorithms, and the effects on system performance experienced as a result.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Direct Aromatic Amination: A New Reaction of Hydroxylamine-O-sulfonic Acid<sup>1</sup> (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect Aromatic Amination: A New Reaction of Hydroxylamine-O-sulfonic Acid1R. N. Keller and Peter A. S. SmithCite this: J. Am. Chem. Soc. 1944, 66, 7, 1122–1124Publication Date (Print):July 1, 1944Publication History Published online1 May 2002Published inissue 1 July 1944https://doi.org/10.1021/ja01235a020Request reuse permissionsArticle Views628Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (385 KB) Get e-Alertsclose Get e-Alerts
Reductive microbial conversion of anthracycline antibiotics (1976)

Reductive conversion of several anthracycline glycosides to their 7-deoxyaglycones occurs during their microaerophilic incubation with strains of Aeromonas hydrophila, Citrobacter freundii, and Escherichia coli. Further, extracts of microaerophilically grown A. hydrophilia catalyze DPNH-dependent reductive conversion of the same compounds. Anthracycline substrates cleaved by both whole cells and by the cell-free system include steffimycin, steffimycin B, nogalamycin, cinerubin A, and daunomycin. Investigation of glycoside cleavage as a function of both time and anthracycline concentration demonstrated the superiority of A. hydrophila over C. freundii and E. coli in regard to reaction rate and efficiency of conversion. Interestingly, some degree of anaerobicity was required for glycoside cleavage by all three organisms. Evidence supporting 7-deoxyaglycone formation via direct reductive cleavage, as opposed to a multienzyme-catalyzed process involving hydrolysis followed by dehydration and reduction, includes the following. Equilibrium mixtures of glycoside substrate and 7-deoxyaglycone product prepared using both whole cells and their extracts display no anthracycline hydrolysis products. Further, authentic steffimycinone (aglycone), the expected product of hydrolytic sugar cleavage of steffimycin, was shown to be converted to 7-deoxysteffimycinone (7-deoxyaglycone) at a rate slower than steffimycin. These data indicate that, if steffimycinone were present as an unbound metabolic intermediate, it should have been visible in the equilibrium mixture, but none was detected.
Function of subscapularis after surgical treatment for recurrent instability of the shoulder using a bone-block procedure (2005)

We compared the long-term function of subscapularis after the Latarjet procedure using two surgical approaches. We treated 102 patients (106 shoulders) with a mean age of 26.8 years (15 to 51) with involuntary unidirectional recurrent instability. The operation was carried out through an L-shaped incision with trans-section of the upper two-thirds of the muscle in 69 cases and with a subscapularis split in 37. All clinical results were assessed by the Rowe and the Duplay scores and the function of subscapularis by evaluating the distance and strength at the lift-off position. Bilateral CT was performed in 77 patients for assessment of fatty degeneration. The mean follow-up was 7.5 years (2 to 15) and 18% of cases were lost to follow-up. The mean Duplay score was 82 of 100 for the L-shaped incision group and 90 of 100 for those with a subscapularis split (p = 0.02). The mean fatty degeneration score was 1.18 after an L-shaped incision compared with 0.12 after subscapularis split (p = 0.001). The subscapularis split approach is therefore recommended.
Sequence of a cDNA clone encoding chicken ribosomal protein S17 (1988)

Sequence of a cDNA clone encoding chicken ribosomal protein S17 Beat Tr€eb, Beat Tr€eb Laboratorium f€r Biochemie I, ETH ZentrumCH-8092 Z€rich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas Schreier, Thomas Schreier Laboratorium f€r Biochemie I, ETH ZentrumCH-8092 Z€rich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Kaspar H. Winterhalter, Kaspar H. Winterhalter Laboratorium f€r Biochemie I, ETH ZentrumCH-8092 Z€rich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Emanuel E. Strehler Emanuel E. Strehler Laboratorium f€r Biochemie I, ETH ZentrumCH-8092 Z€rich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 10, 25 May 1988, Page 4723, https://doi.org/10.1093/nar/16.10.4723 Published: 25 May 1988 Article history Accepted: 12 April 1988 Published: 25 May 1988
Big data curation (2014)

A new mode of inquiry, problem solving, and decision making has become pervasive in our society, consisting of applying computational, mathematical, and statistical models to infer actionable information from large quantities of data. This paradigm, often called Big Data Analytics or simply Big Data, requires new forms of data management to deal with the volume, variety, and velocity of Big Data. Many of these data management problems can be described as data curation. Data curation includes all the processes needed for principled and controlled data creation, maintenance, and management, together with the capacity to add value to data. In this talk, I describe our experience in curating some open data sets. I overview how we have adapted some of the traditional solutions for aligning data and creating semantics to account for (and take advantage of) Big Data.
Purified Wnt‐5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation (2005)

The Wnt family of lipoproteins regulates several aspects of the development of the nervous system. Recently, we reported that Wnt-3a enhances the proliferation of midbrain dopaminergic precursors and that Wnt-5a promotes their differentiation into dopaminergic neurones. Here we report the purification of hemagglutinin-tagged Wnt-5a using a three-step purification method similar to that previously described for Wnt-3a. Haemagglutinin-tagged Wnt-5a was biologically active and induced the differentiation of immature primary midbrain precursors into tyrosine hydroxylase-positive dopaminergic neurones. Using a substantia nigra-derived dopaminergic cell line (SN4741), we found that Wnt-5a, unlike Wnt-3a, did not promote beta-catenin phosphorylation or stabilization. However, both Wnt-5a and Wnt-3a activated dishevelled, as assessed by a phosphorylation-dependent mobility shift. Moreover, the activity of Wnt-5a on dishevelled was blocked by pre-treatment with acyl protein thioesterase-1, indicating that palmitoylation of Wnt-5a is necessary for its function. Thus, our results suggest that Wnt-3a and Wnt-5a, respectively, activate canonical and non-canonical Wnt signalling pathways in ventral midbrain dopaminergic cells. Furthermore, we identify dishevelled as a key player in transducing both Wnt canonical and non-canonical signals in dopaminergic cells.
Chromosome 3p24‐26 and 3p22‐12 loss in human prostatic adenocarcinoma (1997)

Identification of loss of heterozygosity on specific genetic loci is crucial for understanding the pathogenesis of prostate cancer at the molecular level. This is especially important because the deleted regions may contain putative tumor suppressor genes. Chromosome 3p loss appears to be frequently associated with various epithelial cancers. To our knowledge, there is no report on loss of heterozygosity (LOH) of chromosome 3 in human prostate cancer. The present study was designed to investigate the LOH on chromosome 3p in microdissected samples of delineated regions of normal and invasive carcinoma areas of prostatic epithelium from the same tumor sections. For this purpose, DNA was extracted from microdissected normal and tumor cells of 38 prostate cancers, amplified by PCR and analyzed for LOH on chromosome 3p using 6 different polymorphic DNA markers (D3S1560, THRB, D3S647, D3SI298, D3S1228 and D3S1296). Our results suggest that LOH was identified in 34 of 38 cases (89%) with at least one marker. Twelve of 30 informative cases showed LOH at D3S1560; 18 of 22 informative cases showed loss at THRB; 20 of 38 informative cases showed deletion at D3S647; 16 of 38 informative cases showed loss at D3S1298; 12 of 34 informative cases showed LOH at D3S1228; and 6 of 34 informative cases showed LOH at D3S1296 regions. Our results suggest that the LOH is on the 3p24-26 and 3p22-12 regions of the short arm of chromosome 3, indicating 2 discrete areas of deletion on chromosome 3p. The deletion at 3p24-26 and 3p22-12 was not related to the stage or grade of the tumor. Int. J. Cancer, 71:20–25, 1997. © 1997 Wiley-liss, Inc.
The Functional Defect of Factor VIII Leiden, a Genetic Variant of Coagulation Factor VIII (1985)

Factor VIII Leiden is a genetic variant of coagulation factor VIII which has been detected in the plasma of a patient with mild haemophilia A. In this patient's plasma factor VIII procoagulant antigen was in 5-fold excess over factor VIII procoagulant activity, indicating the presence of an abnormal factor VIII molecule. The variant factor VIII was isolated from the patient's plasma, and its functional properties were studied in a factor X-activating system consisting of purified components. The isolated factor VIII Leiden was normally activated by factor Xa and by thrombin, but the activity of the factor VIIIa was about 3% of normal. The defect of factor VIIIa Leiden was studied by comparison with normal factor VIIIa in kinetic experiments of factor Xa formation. The results support the hypothesis that factor VIIIa Leiden has a reduced affinity for phospholipid-bound factor IXa in the intrinsic factor X-activating complex.
GACV for Support Vector Machines (2000)

This chapter contains sections titled: Introduction, The SVM Variational Problem, The Dual Problem, The Generalized Comparative Kullback-Leibler Distance, Leaving-out-one and the GACV, Numerical Results, Acknowledgments
A review of bilateral training for upper extremity hemiparesis (2009)

Upper extremity hemiparesis is the most common post-stroke disability. Longitudinal studies have indicated that 30-66% of stroke survivors do not have full arm function 6 months post-stroke. The current gold standard for treatment of mild post-stroke upper limb impairment is constraint-induced therapy but, because of the inclusion criteria, alternative treatments are needed which target more impaired subjects. Bilateral arm training has been investigated as a potential rehabilitation intervention. Bilateral arm training encompasses a number of methods including: (1) bilateral isokinematic training; (2) mirror therapy using bilateral training; (3) device-driven bilateral training; and (4) bilateral motor priming. Neural mechanisms mediating bilateral training are first reviewed. The key bilateral training studies that have demonstrated evidence of efficacy will then be discussed. Finally, conclusions are drawn concerning clinical implications based on the reviewed literature.
MnBi nanoparticles: Improved magnetic performance through annealing of as-synthesized nanoparticles (2015)

Ferromagnetic MnBi nanoparticles are synthesized and characterized in this study for applications in the realization of hard-soft exchange-coupled nanocomposite structures. The nanoparticles are obtained at room temperature by hot pressing and thermal annealing. X-ray diffraction, vibrating sample magnetometry, and SQUID magnetometry are used for characterization. Observations show that annealing of the nanoparticles results to high coercivity values.
Architecture, Voltage and Components for a Turboelectric Distributed Propulsion Electric Grid (2015)

The development of a wholly superconducting turboelectric distributed propulsion system presents hide unique opportunities for the aerospace industry. However, this transition from normally conducting systems to superconducting systems significantly increases the equipment complexity necessary to manage the electrical power systems. Due to the low technology readiness level (TRL) nature of all components and systems, current Turboelectric Distributed Propulsion (TeDP) technology developments are driven by an ambiguous set of system-level electrical integration standards for an airborne microgrid system (Figure 1). While multiple decades' worth of advancements are still required for concept realization, current system-level studies are necessary to focus the technology development, target specific technological shortcomings, and enable accurate prediction of concept feasibility and viability. An understanding of the performance sensitivity to operating voltages and an early definition of advantageous voltage regulation standards for unconventional airborne microgrids will allow for more accurate targeting of technology development. Propulsive power-rated microgrid systems necessitate the introduction of new aircraft distribution system voltage standards. All protection, distribution, control, power conversion, generation, and cryocooling equipment are affected by voltage regulation standards. Information on the desired operating voltage and voltage regulation is required to determine nominal and maximum currents for sizing distribution and fault isolation equipment, developing machine topologies and machine controls, and the physical attributes of all component shielding and insulation. Voltage impacts many components and system performance.
Properties of the working-set model (1972)

A program's working set W ( t, T ) at time t is the set of distinct pages among the T most recently referenced pages. Relations between the average working-set size, the missing-page rate, and the interreference-interval distribution may be derived both from time-average definitions and from ensemble-average (statistical) definitions. An efficient algorithm for estimating these quantities is given. The relation to LRU (lease recently used) paging is characterized. The independent-reference model, in which page references are statistically independent, is used to assess the effects of interpage dependencies on working-set size observations. Under general assumptions, working-set size is shown to be normally distributed.
Biological Control of Water Pollution (1976)

This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.
Growth Dynamics of Water Drops on a Square-Pattern Rough Hydrophobic Surface (2007)

Condensation on rough or superhydrophobic substrates can induce wetting behavior that is quite different from that of deposited or impinging drops. We investigate the growth dynamics of water drops in a well-controlled condensation chamber on a model rough hydrophobic surface made of square pillars. After having followed growth laws similar to those observed on flat surfaces, a transition to an air-pocket-like state occurred because of the bridging of the drops between the pillars. Another transition to the more stable Wenzel state is later ensured by a noticeable pillar self-drying process. Condensation ends up in a few large drops in a mixed Wenzel penetration regime. The drops are fed by neighboring channels and the adjacent pillars stay almost dry, a remarkable and seemingly general property of rough hydrophobic substrates.
Hexaethynylbenzene (1986)

A molecule that doesn't require any introduction, the title compound 1, can be precipitated as a white powder; solutions in polar solvents are stable. 1 forms transition-metal complexes. The ethynyl groups in the precursors with six Me3SiCC groups on the benzene ring are not exactly linear (X-ray structure analysis).
Experiments on Patent Retrieval at NTCIR-4 Workshop (2004)

the search topic was the claim in a patent document and the search re-sults were the patents that invalidate the claim in the query. Therefore we can calculate the similarities be-tween the IPCs in the search topic and those of each patent document in the collection and use them for the patent-to-patent search. In this task, we extracted the relevance infor-mation from the search results based on the similarities between hierarchi-cal structures of the IPCs, modified the term weighting in the query pro-cessing, and got the final retrieved documents using the updated query. As a result, it was found that there are no significant improvements from term re-weighting when considering the relevance information from the search results using hierarchical in-formation of IPCs. Keywords:similarity metric, hierar-chical structural information, rele-vance feedback, patent retrieval 1