gebhart/patrepeval huggingface dataset:
Touch & connect and touch & select (2009)

Exchanging data between a mobile phone and a computer such as a laptop is still a very cumbersome process. This paper presents two different techniques, touch & connect and touch & select, designed help to overcome this problem and facilitate and speed up spontaneous interactions between such devices. Using touch & connect, the user can physically touch a computer in order to pair a Bluetooth connection and initiate a file transfer between these two devices. Touch & select extends this concept in that users can select a specific object or location on the computer screen by simply touching it with the mobile phone. We report the implementation of these interaction techniques based on Near Field Communication (NFC) tags and present a formal, comparative study focusing on transferring images. The results provide clear evidence of the advantages of touch & connect and touch & select when compared with current Bluetooth-based implementations. Considering task completion time for uploading and downloading pictures, touch & select was 43% and touch & connect 31% faster than the conventional Bluetooth-based approach.
Influence of dosage schedule on renal cortical accumulation of amikacin and tobramycin in man (1991)

The pathogenesis of aminoglycoside nephrotoxicity is directly related to the accumulation of drug within the renal cortex. To identify measures that might prevent aminoglycoside nephrotoxicity, we investigated the influence of various dosage regimens on the renal cortical accumulation of amikacin and tobramycin in man. Patients undergoing nephrectomy for a renal tumour with normal renal function and no proteinuria received (i) a single dose of either amikacin (15 mg/kg) or tobramycin (4.5 mg/kg) given iv over 30 min, or (ii) a 24-h continuous infusion of either drug or (iii) amikacin as two injections of 7.5 mg/kg or tobramycin as three injections of 1.5 mg/kg over the 24 h preceding nephrectomy. Serum aminoglycoside pharmacokinetics were examined and renal cortical tissue was sampled for drug determination at operation. A single injection yielded cortical concentrations of 115.4 +/- 21.8 and 68.9 +/- 30.3 mg/kg for amikacin and tobramycin, respectively. Tissue levels after continuous infusion were 171.7 +/- 42.9 and 100.0 +/- 30.0 mg/kg for amikacin and tobramycin, respectively. Two injections of 7.5 mg/kg amikacin resulted in renal cortical concentrations of 196.9 +/- 54.9 and three injections of 1.5 mg/kg tobramycin resulted in renal cortical concentration of 76.5 +/- 18 mg/kg. The AUC for the three dosage regimens was not significantly different for the two aminoglycosides indicating linear serum pharmacokinetics for these drugs. In the case of amikacin, a single injection resulted in significantly lower drug levels than did a continuous infusion or administration of the same dose over three injections.(ABSTRACT TRUNCATED AT 250 WORDS)
Assessment of ability of murine and human anti-lipid A monoclonal antibodies to bind and neutralize lipopolysaccharide. (1993)

The use of monoclonal antibodies (mAbs) directed to lipid A for the therapy of gram-negative sepsis is controversial. In an attempt to understand their biologic basis of action, we used a fluid-phase radioimmunoassay to measure binding between bacterial lipopolysaccharide (LPS) and two IgM mAbs directed to lipid A that are being evaluated for the treatment of gram-negative bacterial sepsis. Both antibodies bound 3H-LPS prepared from multiple strains of gram-negative bacteria when large excesses of antibody were used, although binding was modest and only slightly greater than control preparations. We also studied the ability of each anti-lipid A antibody to neutralize some of the biological effects of LPS in vitro. Despite large molar excesses, neither antibody neutralized LPS as assessed by the limulus lysate test, by a mitogenic assay for murine splenocytes, or by the production of cytokines interleukin (IL)-1, IL-6, or tumor necrosis factor from human monocytes in culture medium or in whole blood. Our experiments do not support the hypothesis that either of these anti-lipid A mAbs function by neutralizing the toxic effects of LPS.
Communication middleware and software for QoS control in distributed real-time environments (2002)

There has been an increasing need of highly predictable, timely, and dependable communication services with QoS guarantees on an end-to-end basis either for embedded real-time applications or for multimedia-integrated distributed control. Performance objectives used in conventional networks-such as maximizing the throughput, minimizing the response time, or providing fairness to users-are not of the most important concern for both types of applications. Instead, resources should be appropriately reserved and managed to support multidimensional quality of service (QoS) on an end-to-end basis, as well as application-specific tradeoffs among them. The main intent of the paper is thus to address and demonstrate an environment-an integrated set of network resource management techniques, middleware layers, and network software-for supporting multi-dimensional QoS on an end-to-end basis in distributed real-time environments. The authors first provide an analytic QoS framework Then, they elaborate on the algorithms and mechanisms to provide such network services. To empirically analyze the behavior of the proposed components, they are currently implementing them as software layers on top of the Sun Solaris operating system, and comment on the implementation status.
The manganese nitrides η‐Mn3N2 and θ‐Mn6N5 + x: nuclear and magnetic structures (2000)

Neutron powder diffraction measurements on η-Mn3N2 and θ-Mn6N5 + x (x = 0.26) revealed the nuclear and magnetic structures of these metallic interstitial compounds.
Probabilistic learning of task-specific visual attention (2012)

Despite a considerable amount of previous work on bottom-up saliency modeling for predicting human fixations over static and dynamic stimuli, few studies have thus far attempted to model top-down and task-driven influences of visual attention. Here, taking advantage of the sequential nature of real-world tasks, we propose a unified Bayesian approach for modeling task-driven visual attention. Several sources of information, including global context of a scene, previous attended locations, and previous motor actions, are integrated over time to predict the next attended location. Recording eye movements while subjects engage in 5 contemporary 2D and 3D video games, as modest counterparts of everyday tasks, we show that our approach is able to predict human attention and gaze better than the state-of-the-art, with a large margin (about 15% increase in prediction accuracy). The advantage of our approach is that it is automatic and applicable to arbitrary visual tasks.
The Karnofsky performance status scale: An examination of its reliability and validity in a research setting (1984)

The Karnofsky Performance Status Scale (KPS) is widely used to quantify the functional status of cancer patients. However, limited data exist documenting its reliability and validity. The KPS is used in the National Hospice Study (NHS) as both a study eligibility criterion and an outcome measure. As part of intensive training, interviewers were instructed in and tested on guidelines for determining the KPS levels of patients. After 4 months of field experience, interviewers were again tested based on narrative patient descriptions. The interrator reliability of 47 NHS interviewers was found to be 0.97. The construct validity of the KPS was analyzed, and the KPS was found to be strongly related (P less than 0.001) to two other independent measures of patient functioning. Finally, the relationship of the KPS to longevity (r = 0.30) in a population of terminal cancer patients documents its predictive validity. These findings suggest the utility of the KPS as a valuable research tool when employed by trained observers.
Electrodeposition of Magnesium and Beryllium from Organic Baths (1971)

SummarySolutions that are feasible for electrodepositing magnesium were prepared from Grignard reagents with the addition of boranes in ether solutions. A typical bath consisted of methylmagnesium chloride, 3-molar (dissolved in tetrahydrofuran), and 1-molar in triethylboron. The deposits were white, ductile and contained at least 99% of Mg. Cathode and anode current efficiencies were 100%. A similar beryllium plating solution, prepared with beryllium dimethyl and decaborane, yielded dark grey, coherent deposits containing 85% to 90% beryllium.
Nanostructured Materials (1992)

The heterogenous structure of nanostructured materials distinguishes them from materials such as glasses which have a homogeneously disordered microstructure. In the figure, the atoms marked in black are in the center of the grains, the white one forming the surface of the individual grains, this structure resulting in the remarkable properties of the materials. magnified image
Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. (1989)

We report here the nucleic acid sequence and deduced amino acid sequence of a cDNA for TIS11, a gene induced in 3T3 cells by tetradecanoyl phorbol acetate.
Improving information extraction and translation using component interactions (2007)

The traditional natural language processing pipeline incorporates multiple stages of linguistic analysis. Although errors are typically compounded through the pipeline, it is possible to reduce the errors in one stage by harnessing the results of the other stages. 
This thesis presents a new framework based on component interactions to approach this goal. The new framework applies all stages in a suitable order, with each stage generating multiple hypotheses and propagating them through the whole pipeline. Then the feedback from subsequent stages is used to enhance the target stage by re-ranking these hypotheses, and then produce the best analysis. 
The effectiveness of this framework has been demonstrated by substantially improving the performance of Chinese and English entity extraction and Chinese-to-English entity translation. The inference knowledge includes mono-lingual interactions among information extraction stages such as name tagging, coreference resolution, relation extraction and event extraction, as well as cross-lingual interaction between information extraction and machine translation. 
Such symbiosis of analysis components allows us to incorporate information from a much wider context, spanning the entire document and even going across documents, and utilize deeper semantic analysis; it will therefore be essential for the creation of a high-performance NLP pipeline.
Synthesis of 5-acetamido-2-acetylpiperidine (1971)

The synthesis of the title compound (10) in eight stages is described. A procedure for the reductive acylation of a pyridyl nitro-group is presented. The use of rhodium as a catalyst for nuclear reduction of pyridines in aqueous solution at room temperature is discussed and examples of this procedure are given. N.m.r. data are presented for a number of 2,5-disubstituted pyridines and piperidines and the formation (and n.m.r. spectrum) of 2 3-bis-(5-nitro-2-pyridyl)butane (6) in the preparation of 1-(5-nitro-2-pyridyl)acetaldehyde oxime (4) is reported.
Electrosynthesis with Perfluorinated Ionomer Membranes in Chlor-Alkali Cells (1982)

The field of electrochemical science has been quietly revolutionized during this past decade by development and application of a new family of perfluorinated ionomer ion-exchange membrane separators in concert with new cell designs and stable electrode systems for electrosynthesis (1) (2). These new membranes are much more than structural supports. The perfluorocarbon structures impart oxidative and hydrolytic resistance to the membrane materials while their cationic strength rejects anions. This combination of unusual ionic character and exceptional chemical resistance makes these materials prime candidates for use as electrolytic separators for electrosynthesis (3). In recent years, a number of electrolytic processes have utilized membranes in producing both anodic and cathodic products. By far, however, the most important application of this technology has been in the chlor-alkali industry. Intense commercial and academic interest has been focused into this field during the past decade so that ion exchange theory as applied to membranes is
<i>In vitro</i> water resistance testing using SPF simulation based on spectroscopic analysis of rinsed sunscreens (2018)

Despite the small discrepancy remaining between WRR values obtained from the in vitro solution method and in vivo method, which itself shows variability in results, this work provided a new insight into the in vitro testing of water resistance of sunscreens.
A Three-Dimensional Coculture of Enterocytes, Monocytes and Dendritic Cells To Model Inflamed Intestinal Mucosa in Vitro (2010)

While epithelial cell culture models (e.g., Caco-2 cell line) are widely used to assess the absorption of drug molecules across healthy intestinal mucosa, there are no suitable in vitro models of the intestinal barrier in the state of inflammation. Thus development of novel drugs and formulations for the treatment of inflammatory bowel disease is largely bound to animal models. We here report on the development of a complex in vitro model of the inflamed intestinal mucosa, starting with the selection of suitable enterocyte cell line and proinflammatory stimulus and progressing to the setup and characterization of a three-dimensional coculture of human intestinal epithelial cells and immunocompetent macrophages and dendritic cells. In the 3D setup, controlled inflammation can be induced allowing the mimicking of pathophysiological changes occurring in vivo in the inflamed intestine. Different combinations of proinflammatory stimuli (lipopolysaccharides from Escherichia coli and Salmonella typhimurium, interleukin-1β, interferon-γ) and intestinal epithelial cell lines (Caco-2, HT-29, T84) were evaluated, and only Caco-2 cells were responsive to stimulation, with interleukin-1β being the strongest stimulator. Caco-2 cells responded to the proinflammatory stimulus with a moderate upregulation of proinflammatory markers and a slight, but significant, decrease (20%) of transepithelial electrical resistance (TEER) indicating changes in the epithelial barrier properties. Setting up the coculture model, macrophages and dendritic cells derived from periphery blood monocytes were embedded in a collagen layer on a Transwell filter insert and Caco-2 cells were seeded atop. Even in the presence of immunocompetent cells Caco-2 cells formed a tight monolayer. Addition of IL-1β increased inflammatory cytokine response more strongly compared to Caco-2 single culture and stimulated immunocompetent cells proved to be highly active in sampling apically applied nanoparticles. Thus the 3D coculture provides additional complexity and information compared to the stimulated single cell model. The coculture system may serve as a valuable tool for developing drugs and formulations for the treatment of inflammatory bowel diseases, as well as for studying the interaction of xenobiotics and nanoparticles with the intestinal epithelial barrier in the state of inflammation.
Clinical value of the measurement of Mycobacterium tuberculosis specific antibody in pulmonary tuberculosis. (1992)

Antigen or epitope specific serology may help in the diagnosis, assessment of prognosis, and monitoring of chemotherapy in patients with pulmonary tuberculosis.
Visible mechanochromic responses of spiropyrans in crystals via pressure-induced isomerization (2015)

The isomerization of spiropyrans in crystals was realized under high pressure, and the corresponding mechanochromic response could be observed by the naked eye. In situ UV-Vis spectroscopy study demonstrated that the equilibrium constant increases with the increasing pressure, from which we proposed that the negative volume of reaction determined the isomerization under high pressure.
Effect of Chlorination on <i>Microcystis aeruginosa</i> Cell Integrity and Subsequent Microcystin Release and Degradation (2007)

The proliferation of cyanobacteria in drinking water sources is problematic for water authorities as they can interfere with water treatment processes. Studies have shown that oxidants such as chlorine can enhance the coagulation of cyanobacteria; however, chlorine can potentially lyse cyanobacterial cells, releasing toxic metabolites. Chlorine also has the potential to effectively degrade these toxins. This study evaluated the effect of chlorine on the cell integrity of toxic Microcystis aeruginosa in reservoir water using flow cytometry. In addition, the effect of chlorine on the subsequent release and degradation of microcystin toxins was systematically assessed. Cell lysis occurred at chlorine exposure values between 7 and 29 mg min/L, which is within the range of normal disinfection practices. Intracellular toxin was shown to be released from damaged cells at a rate three times faster than it was degraded by chlorine. The degradation of extracellular microcystin by chlorine was found to be dependent upon the pH, chlorine exposure, and the presence of cyanobacterial cells.
Smart contract model for complex reality transaction (2019)

Purpose The application of smart contract can greatly reduce transaction costs and improve transaction efficiency. The existing smart contract are expensive, single application scenario and inefficient. This paper aims to propose a new smart contract model to solve these problems. Design/methodology/approach By investigating the research history, models and platforms, this paper summarizes the shortcomings of existing smart contracts. Based on the content and architecture of traditional contract, a smart contract model with wider application scope is designed. Findings In this paper, several models are used to describe the operation mechanism of smart contracts. To facilitate computer execution, a decomposition method is proposed, which divides smart contracts into several sub-contracts. Then, the advantages and deployment methods of smart contract are discussed. On this basis, a specific example is given to illustrate how the application of smart contract will change our life. Originality/value Smart contract is gradually applied to more fields. In this paper, the structure and operation mechanism of smart contract system in reality are given, which will be beneficial to the application of smart contract to more complex systems.
Borehole Failure: Safe Drawdown Pressures and Wellbore Damage Radius (2000)

Abstract This paper addresses the problem of onset of failure and the subsequent development and propagation of the failed (or plastic) zone during production. It uses an elasto/plastic formulation1 to find the distance of the damaged radius for cased and uncased wells. Numerical examples and laboratory tests are used to show the onset of failure and the growth of the plastic zone.
Concurrent error detection using watchdog processors-a survey (1988)

Concurrent system-level error detection techniques using a watchdog processor are surveyed. A watchdog processor is a small and simple coprocessor that detects errors by monitoring the behavior of a system. Like replication, it does not depend on any fault model for error detection. However, it requires less hardware than replication. It is shown that a large number of errors can be detected by monitoring the control flow and memory-access behavior. Two techniques for control-flow checking are discussed and compared with current error-detection techniques. A scheme for memory-access checking based on capability-based addressing is described. The design of a watchdog for performing reasonable checks on the output of a main processor by executing assertions is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes (1997)

Friedreich ataxia is a progressive neurodegenerative disorder caused by loss of function mutations in the frataxin gene. In order to unravel frataxin function we developed monoclonal antibodies raised against different regions of the protein. These antibodies detect a processed 18 kDa protein in various human and mouse tissues and cell lines that is severely reduced in Friedreich ataxia patients. By immunocytofluorescence and immunocytoelectron microscopy we show that frataxin is located in mitochondria, associated with the mitochondrial membranes and crests. Analysis of cellular localization of various truncated forms of frataxin expressed in cultured cells and evidence of removal of an N-terminal epitope during protein maturation demonstrated that the mitochondrial targetting sequence is encoded by the first 20 amino acids. Given the shared clinical features between Friedreich ataxia, vitamin E deficiency and some mitochondriopathies, our data suggest that a reduction in frataxin results in oxidative damage.
Controlling morphology of peptide‐based soft structures by covalent modifications (2012)

Control of gross morphology of soft matter remains an area of continued interest. Towards this goal, this paper describes conjugation of mannose residues and introduction of thiol functionalities to diphenylalanine (FF) dipeptide, a fibrillating motif from amyloid-β peptide, as covalent modifiers of its solution-phase self-assembly process. It was found that covalent attachment of a single mannose residue to FF leads to the retention of tubular structures, whereas the conjugation of two mannose units, linked through a Lys residue, resulted in a dramatic change from tubular morphology to spherical structures. However, a similar switch to spherical objects could be achieved by introducing a thiol residue in the mono-mannosylated FF dipeptide. Interestingly, these glycopeptides also exhibited interaction with concanavalin A, thereby providing an indirect evidence for the availability of mannose units for the process of lectin-carbohydrate interaction in the self-organized state.
Management of ‘no‐reflow’ complicating reperfusion therapy (2008)

No-reflow phenomenon, defined as inadequate myocardial perfusion of the adequately dilated target vessel without evidence of angiographic mechanical obstruction. It is a multifactorial, well-recognised, secondary phenomenon following reperfusion therapy such as thrombolysis or percutaneous coronary interventions (PCI). The pathophysiological mechanisms leading to the no-reflow state are incompletely understood. Embolization of the atheromatous material to the distal vasculature and intense arteriole vasospasm caused by microembolization of platelet-rich thrombi that release vasoactive agents resulting in microvascular obstructions are likely mechanisms. Current prophylaxis and management strategies are derived from limited clinical data. Intracoronary verapamil, adenosine and nitroprusside have been most frequently studied and administered for angiographic no-reflow during PCI for acute myocardial infarction or saphenous vein graft (SVG) lesions and have been shown to improve epicardial flow and microvascular perfusion. The use of distal embolic protection devices in SVG interventions also provide microvascular protection and improve clinical outcomes. However, by far the most important measures are prevention and anticipation during PCI as once no-reflow established, complete reversal of the situation may not be possible.