gebhart/patrepeval huggingface dataset:
Fluvoxamine for the treatment of depression and parkinsonism in progressive supranuclear palsy (2002)

Progressive supranuclear palsy (PSP) is a parkinsonian-like disorder characterized by postural instability, rigidity, bradykinesia, supranuclear ocular palsy, dysarthria, dysphagia and dementia. There is no satisfactory treatment. A 68-year-old woman with initial progressive supranuclear palsy is described, who was generally apathetic, withdrawn, lacked spontaneity in speech and behavior, and suffered episodes of depression. Treatment with levodopa/carbidopa was ineffective in controlling her parkinsonism and depression, but these symptoms responded to fluvoxamine. This response may be related to fluvoxamine's putative effect on the serotonin system.
ICTNET at Federated Web Search Track 2013 (2013)

This paper is about work done for result merging task of TREC 2013 Federated Web Track. We introduce three methods for calculating score of documents. These methods are based on linear combination with scores of document fields. The distinction is different weight factors. Score of base line method is the combination with score of basic html fields. Page rank score is added in second method. Documents with lower score are filtered during the third method.
Super resolving texture mapping from multiple view images for 3D model construction (2002)

There are wide varieties of applications of 3D modeling from real images, which can generate virtual view images by rendering the input images on to a 3D shape model. Because the virtual viewpoint is not generally at the same point, the synthesized image in a virtual view does not have sufficient resolution. To improve this resolution problem, we propose a method for improving the rendered texture resolution. For each vertex of the 3D shape model, the position of the vertex is adjusted to improve the texture of the neighboring triangle patches. For the improvement, the position of the vertex is adjusted by comparing the observation (input image) with the projected image of the model texture. By repeating the visit to every vertex, not only can a super-resolved texture be obtained but also a more accurate 3D patch model. By performing experiments using synthesized multiple-view images of 51 calibrated cameras around the object scene and a real VTR image sequence, it is demonstrated that the proposed method can successfully provide a super-resolved texture image with an improved 3D shape model.
Ring transformations of heterocyclic compounds with nucleophiles. Part XVI. Degenerate ring transformations of 1,3‐diethyl‐1,4(3,4)‐dihydro‐4‐oxopyrimidinium tetrafluoroborates with ammonia (1977)

Abstract Treatment of 1,3‐diethyl‐1,4(3,4)‐dihydro‐4‐oxopyrimidinium tetrafluoroborate and its 2‐phenyl, 6‐phenyl, 6‐methyl and 6‐ethoxy derivatives with aqueous ammonia resulted in the formation of a mixture of open‐chain compounds i.e. N ‐formyl(acetyl,benzoyl)‐ N ‐ethyl‐3‐(ethylamino)‐acrylamides and N ‐ethyl‐3‐[formyl(acetyl,benzoyl)ethylamino]‐acrylamides. They are formed by cleavage of the pyrimidine ring between the N(1)‐C(2) and N(3)‐C(2) bond, respectively. In liquid ammonia the same ring cleavage generally occurs; however, in the case where a 6‐ethoxy group is present, recyclisation can take place, leading to 6‐(ethylamino)pyrimidine derivatives. This degenerate ring transformation has been observed also with the 2‐methyl and 2‐phenyl derivative of 1,3‐diethyl‐1,4(3,4)‐dihydro‐6‐ethoxy‐4‐oxopyrimidinium tetrafluoroborate. Evidence is presented by means of 1 H‐NMR and 13 C‐NMR spectroscopy that all these reactions are iniated by attack of NH 3 at the C(2)‐position. Some of the above‐mentioned open‐chain compounds underwent a ring closure to the initially used 1,3‐diethyl‐1,4(3,4)‐dihydro‐4‐oxopyrimidinium tetrafluoroborates on treating them with hydrofluoroboric acid in absolute ethanol.
Semiblind Turbo Equalization Scheme for LTE Uplink Receiver (2012)

An advanced receiver scheme for long-term evolution (LTE) uplink is proposed. The scheme combines semiblind channel estimation and turbo equalization and is based on an approximate expectation-maximization (EM) algorithm. The receiver iterates between demodulation of the data symbols using frequency-domain soft interference cancelation, turbo decoding, and semiblind channel estimation that utilizes the soft symbols extracted from the turbo decoder output. It is shown that, using the proposed scheme, one can replace most of the dedicated pilots used in the current LTE scheme with data information and obtain significantly better performance with the same bandwidth. Moreover, an efficient implementation of the proposed algorithm utilizing the discrete/fast Fourier transform (DFT/FFT) properties used in the single-carrier orthogonal frequency-division multiplexing (SC-OFDM) scheme is presented.
Traffic engineering and signaling technologies in photonic-GMPLS-router networks (2003)

This paper describes multilayer traffic engineering and signaling technologies in a photonic-GMPLS-router network. Multilayer traffic engineering, which yields the dynamic cooperation of IP and photonic layers, is described to provide IP services cost-effectively. To realize multilayer traffic engineering, we propose the OSPF extension, which advertises both the number of total wavelengths and the number of unreserved wavelengths, and the RSVP-TE extension, which realizes the least number of wavelength conversions. In addition, this paper presents a heuristic-based multilayer topology design scheme that uses IP traffic measurements in a generalized multiprotocol label switch (GMPLS). Our design scheme yields the optical label switch path (OLSP) network topology, i.e. OLSP placement, that minimizes network cost, in response to fluctuations in IP traffic demand. In other words, the OLSP network topology is dynamically reconfigured to match IP traffic demand. Networks are reconfigured by the proposed scheme so as to utilize the network resources cost-effectively.
Management of malignant testicular tumors in children (1976)

The result of therapy of 67 cases of children with malignant testicular tumors is presented. The majority of these cases were embryonal carcinoma in which metastases had occurred in the retroperitoneal lymph nodes, lungs, and bones. Long-term survival was obtained in 89% of the cases treated by simple orchiectomy followed by retroperitoneal irradiation. Two cases with metastases benefitted from chemotherapy. The prognosis of embryonal carcinoma of the testis is correlated with the age of the patient and the histologic pattern of the carcinoma; early detection and appropriate treatment are most important for its cure.
Flow-Through vs Flow-Over: Analysis of Transport and Binding in Nanohole Array Plasmonic Biosensors (2010)

We quantify the efficacy of flow-through nanohole sensing, as compared to the established flow-over format, through scaling analysis and numerical simulation. Nanohole arrays represent a growing niche within surface plasmon resonance-based sensing methods, and employing the nanoholes as nanochannels can enhance transport and analytical response. The additional benefit offered by flow-through operation is, however, a complex function of operating parameters and application-specific binding chemistry. Compared here are flow-over sensors and flow-through nanohole array sensors with equivalent sensing area, where the nanohole array sensing area is taken as the inner-walls of the nanoholes. The footprints of the sensors are similar (e.g., a square 20 μm wide flow-over sensor has an equivalent sensing area as a square 30 μm wide array of 300 nm diameter nanoholes with 450 nm periodicity in a 100 nm thick gold film). Considering transport alone, an analysis here shows that given equivalent sensing area and flow rate the flow-through nanohole format enables greatly increased flux of analytes to the sensing surface (e.g., 40-fold for the case of Q = 10 nL/min). Including both transport and binding kinetics, a computational model, validated by experimental data, provides guidelines for performance as a function of binding time constant, analyte diffusivity, and running parameters. For common binding kinetics and analytes, flow-through nanohole arrays offer ∼10-fold improvement in response time, with a maximum of 20-fold improvement for small biomolecules with rapid kinetics.
Purine Salvage Pathways in the Intraerythrocytic Malaria Parasite <i>Plasmodium falciparum</i> (2008)

Purines enter the intraerythrocytic malaria parasite via a fast, low-affinity, broad-capacity process that can be attributed primarily to the parasite plasma membrane transporter PfNT1. The reliance of the parasite on PfNT1 makes this protein a worthy target for further investigation, while the determination of the roles played by PfNT2, PfNT3, and PfNT4 in parasite physiology should also prove interesting. Within the parasite, the metabolism of purines appears to be funneled through hypoxanthine by the sequential actions of ADA and PNP, prior to phosphoribosylation of hypoxanthine by PRT. The fact that hypoxanthine is the main purine source found in human serum suggests that PfADA and PfPNP are unlikely to play an essential function under physiological conditions or be considered good drug targets. However, the apparent dependence of the parasite on PfHGXPRT for nucleotide synthesis makes this protein a promising drug target. Efforts to develop compounds that can distinguish between this enzyme and the human counterpart are well justified and may well form the basis for future antimalarial drug strategies.
SMPTE Tutorial: Wavelets and Image Compression (1994)

Wavelet technology combines powerful new mathematical methods for representing functions with efficient software and very large scale integration (VLSI) implementations. Government and commercial evaluations have shown that wavelet-based still-image compression outperforms all other methods considered, including those based on the discrete cosine transform (DCT).
Path Network Recovery Using Remote Sensing Data and Geospatial-Temporal Semantic Graphs (2016)

Remote sensing systems produce large volumes of high-resolution images that are difficult to search. The GeoGraphy (pronounced Geo-Graph-y) framework [2, 20] encodes remote sensing imagery into a geospatial-temporal semantic graph representation to enable high level semantic searches to be performed. Typically scene objects such as buildings and trees tend to be shaped like blocks with few holes, but other shapes generated from path networks tend to have a large number of holes and can span a large geographic region due to their connectedness. For example, we have a dataset covering the city of Philadelphia in which there is a single road network node spanning a 6 mile x 8 mile region. Even a simple question such as "find two houses near the same street" might give unexpected results. More generally, nodes arising from networks of paths (roads, sidewalks, trails, etc.) require additional processing to make them useful for searches in GeoGraphy. We have assigned the term Path Network Recovery to this process. Path Network Recovery is a three-step process involving (1) partitioning the network node into segments, (2) repairing broken path segments interrupted by occlusions or sensor noise, and (3) adding path-aware search semantics into GeoQuestions. This report covers the path network recovery process, how it is used, and some example use cases of the current capabilities.
Controlling fugitive dust emissions in material handling operations (1992)

The primary mechanism of fugitive dust generation in bulk material handling transfer operations is by dispersion of dust in turbulent air induced to flow with falling or projected material streams. This paper returns to basic theories of particle dynamics and fluid mechanics to quantify the dust generating mechanism by rational analysis. Calculations involving fluid mechanisms are made easier by the availability of the personal computer and the many math manipulating programs. Rational analysis is much more cost effective when estimating collection air volumes to control fugitive emissions; especially in enclosed material handling transfers transporting large volumes of dusty material. Example calculations, using a typical enclosed conveyor-to-conveyor transfer operation are presented to illustrate and highlight the key parameters that determine the magnitude of induced air flow that must be controlled. The methods presented in this paper for estimating collection air volumes apply only enclosed material handling transfers, exhausted to a dust collector. Since some assistance to the control of dust emissions must be given by the material handling transfer chute design, a discussion of good transfer chute design practice is presented. 4 refs., 2 figs., 2 tabs.
让创新成为组织的一项例行功能——皮斯特·T的创新型组织理论 (2003)

由传统型组织发展到学习型组织是一个伟大的进步。 由学习型组织发展到创新型组织是一项更大的进步。 皮斯特·T的创新型组织理论为组织从学习型向创新型转变提供了一把钥匙。 人类的历史在进入21世纪时,发生了比以往历史上任何时期都无法与之比拟的变化。贸易壁垒正在逐步打破,全球经济正在融为一体,恐怖主义成为人类的通敌,强权主义
Syntheses of Ligands Containing Two and Three 2,2’-(Bisamino)diphenyl Ether Units Designed for Molecular Self-Assembly on Lithiation (1996)

The syntheses of polyamines containing two or three 2,2’-(bisamino)diphenyl ether units linked together, designed for self-assembly following lithiation, are reported. The X-ray crystal structures of two of the bis[2,2’(bisamido)diphenyl ethers] are described. The ligand, which is linked by an ethylene glycol spacer, exhibits a coiled conformation constrained by intramolecular hydrogen bonds and supplemented by [CH-π] interactinos. The ligand, which is linked by a more rigid bridge, containing a paraphenylene unit, displays a stretched conformation stabilised by intramolecular hydrogen bonds and intramolecular T-type aromatic-aromatic edge-to-face interactions.
Psychoacoustic Measures of Tinnitus (2000)

Abstract This report reviews research from the 1930s to the present that has extended our understanding by investigating the characteristics of tinnitus that can be studied using psychoacoustic techniques. Studies of tinnitus masking and residual inhibition began in the 1970s, leading to the therapeutic use of tinnitus masking and a consequent increase in research devoted to tinnitus measurement. In 1981, the CIBA Foundation symposium on tinnitus advocated general adoption of four tinnitus measures: (1) pitch, (2) loudness, (3) maskability, and (4) residual inhibition. Since then, psychoacoustic research into all four topics has proliferated, yielding many valuable insights and controversies concerning the details of measurement techniques. A consensus has emerged that neither the loudness nor other psychoacoustic measures of tinnitus bear a consistent relation to the severity or perceived loudness of tinnitus. Nevertheless, quantification is needed in clinical trials of proposed treatments and in a variety of other types of tinnitus research. Standardization of techniques for specifying the acoustic parameters of tinnitus thus continues to be an important research goal. Abbreviations: ABLB = alternating binaural loudness balance, DL = difference limen, FCDS = forced-choice double staircase, MML = minimum masking level, PLU = personal loudness unit, Rl = residual inhibition
Dapagliflozin for the Treatment of Type 2 Diabetes (2009)

Dapagliflozin represents the first in a new class of drugs that may represent a promising new option in the treatment of type 2 diabetes. Results of ongoing Phase 3 clinical trials are necessary to demonstrate efficacy and safety of this agent across various patient populations and clinical scenarios.
Erosion Resistant Nano Technology Coatings for Gas Turbine Components (2007)

Solid particle and liquid particle erosion in the compressor section of gas turbines and steam turbine vanes and blades lead to significant reduction in turbine efficiency over time. This results in increased downtime and operating cost of the power plants. Some of the conventional coatings and erosion protection shields used by the currently available commercial processes have limitations in their temperature and erosion protection capabilities. Under a project funded by the Electric Power Research Institute (EPRI), nano coatings with thickness within 40 microns (about 1.5 mils) have been produced on test samples using a state-of-the-art Plasma Enhanced Magnetron Sputtering (PEMS) technique. Five coatings were selected for the initial screening tests. Titanium silicon carbonitride nano-composite (TiSiCN), stellite and modified stellite, chromium carbide and Ti-TiN nano layered coatings are being studies in this project. The substrate selection is based on some of the alloys currently used in aeroderivative engine compressor blades, land based gas turbine compressor blades and steam turbine blades and vanes. They include titanium alloys and stainless steels. The PEMS coating technique differs significantly from the conventional techniques such as air plasma spray (APS), low-pressure plasma spray (LPPS), diffusion coatings, chemical or physical vapor deposition (CVD or PVD) used on blades and vanes. PEMS method involves a magnetron sputtering process using a vacuum chamber with an independently generated plasma source from which high current density can be obtained. This method used heavy ion bombardment prior to and during deposition to increase the coating adhesion and limit columnar growth in the coatings. Single-layered thick nitrides coatings up to about 80μm and thick carbonitride coatings of TiSiCN about 30μm have been obtained by this process. A novel method using trimethylsilane gas instead of solid targets was successful in producing this nanocomposite. Initial tests conducted on some of the coated titanium alloy samples produced thus far show significant improvement in the erosion resistance in laboratory sand erosion tests. It was observed that TiSiCN exhibited the best low-angle erosion resistance — nearly 25 times higher than the uncoated Ti-6Al-4V and about 5–10 times higher than all other nitrides. This paper covers a brief description of the deposition technology and the properties of the coatings. Scanning Electron Microscopy (SEM) with Energy Dispersive Spectroscopy (EDS), and X-Ray diffraction (XRD) analysis were used to study the microstructure and morphology of these coatings. Nanoindentation was conducted to determine the hardness and Young’s modulus, while sand erosion tests were conducted to rank the erosion resistance of the coatings produced using several processing variables.
Learning Curves, Model Selection and Complexity of Neural Networks (1992)

Learning curves show how a neural network is improved as the number of training examples increases and how it is related to the network complexity. The present paper clarifies asymptotic properties and their relation of two learning curves, one concerning the predictive loss or generalization loss and the other the training loss. The result gives a natural definition of the complexity of a neural network. Moreover, it provides a new criterion of model selection. 1 INTRODUCTION The learning curve shows how well the behavior of a neural network is improved as the number of training examples increases and how it is related with the complexity of neural networks. This provides us with a criterion for choosing an adequate network in relation to the number of training examples. Some researchers have attacked this problem by using statistical mechanical methods (see Levin et al. [1990], Seung et al. [1991], etc.) and some by information theory and algorithmic methods (see Baum and Haussler ...
A dynamic debugger for asynchronous distributed algorithms (1994)

LPdbx is a distributed runtime debugger for loosely coupled parallel processors with an iconic interface. When a program suspends, users can insert additional breakpoints and examine global variables, structures, and pointer references. It has been used to debug banking and transportation applications and is available for distribution.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy. (2003)

The ubiquitin/proteasome-dependent protein degradation pathway plays an essential role in both up-regulation of cell proliferation and down-regulation of cell death in human cancer cells. The idea that proteasome function is required for tumor cell survival has prompted the design, synthesis and evaluation of various pharmacological proteasome inhibitors. Both in vitro and in vivo experimental and clinical results have demonstrated the potential use of proteasome inhibitors as novel anticancer drugs.
Depth Perception Control during Car Vibration by Hidden Images on Monocular Head-Up Display (2013)

A novel depth perception control method for a monocular head-up display (HUD) in a car has been developed, which is called the dynamic perspective method. The method changes a size and a position of the HUD image such as arrow for depth perception and achieves a depth perception position of 120 [m] within an error of 30% in a simulation. However, it is difficult to achieve an accurate depth perception in the real world because of car vibration. To solve this problem, we focus on a property, namely, that people complement hidden images by previous continuously observed images. We hide the image on the HUD when the car is vibrated very much. We aim to point at the accurate depth position by using see-through HUD images while having users complement the hidden image positions based on the continuous images before car vibration. We developed a car that detects big vibration by an acceleration sensor and is equipped with our monocular HUD. Our new method pointed at the depth position more accurately than the previous method, which was confirmed by t-test.
Resist trimming in high-density CF4/O2 plasmas for sub-0.1 μm device fabrication (2002)

Resist trimming using a CF4/O2 plasma generated by an inductively coupled high-density plasma source is investigated. Results show that the resist trimming process is applicable for the fabrication of a sub-0.1 μm polysilicon gate electrode with conventional 248 nm lithography. The trim rate depends strongly on gas composition, temperature, rf source power, bias voltage, reactor pressure and total gas flow. The trim rate increases with increasing temperature, rf source power and reactor pressure but decreases with higher bias voltage. For a typical trimming condition at gas composition of CF4 and O2 with a ratio of 3.3:1, the resist trim rates are 1.0 and 1.2 nm/s for dense and isolated lines, respectively. By examining the effect of various process parameters, it is found that the trimming process is dominated by the neutral reactant species. Angle-resolved x-ray photoelectron spectroscopy shows that a fluorinated carbon oxyfluoride polymer is deposited on the sidewall of photoresist. The degree of carbon fluorination of the film is influenced by the process parameters. A more fluorinated film, obtained at lower bias voltage and higher source power, gives more trimming.