gebhart/patrepeval huggingface dataset:
Analysis and Design of Segmented Dampers for Rotor Dynamic Control (1982)

Dampers have become of increasing importance in the control of shaft vibration of rotating equipment which must operate through one or more critical speeds. This paper presents the analytical results for the study of a new class of damper, the segmented film damper. A series of isolated segments of fluid are used rather than a continuous film as in the traditional squeeze film damper. This configuration provides energy dissipation through fluid viscosity within the film segments and through oriface flow in the supply and exit ports for each segment. The pressure distribution within an individual segment is developed on the basis of Reynolds equation with appropriate boundary conditions. The effects of various parameters are discussed in terms of this pressure distribution. The geometric effects of multiple segments are derived for both input, how shaft motion excites each segment, and output, how the segments’ pressure distributions combine to provide a net force. The damping force is shown to be linear for a wide range of operating conditions, speed and unbalance, and thus validly expressed in terms of a damping coefficient. Additionally, this class of damper is shown to have no radial stiffness. The limitations and implications for the designer are discussed in detail. A structured design procedure is given for the selection of parameter values, and a design example with numerical values is included.
Dose-Dependent Doxycycline-Mediated Adrenocorticotropic Hormone Secretion from Encapsulated Tet-On Proopiomelanocortin Neuro2A Cells in the Subarachnoid Space (1998)

We previously reported that polymer-encapsulated mouse neuroblastoma cells that are capable of secreting beta-endorphin may reduce pain sensitivity in rats after capsule implantation into the cerebrospinal fluid (CSF)-filled subarachnoid space of the spinal cord. The neuroblastoma cells carry the proopiomelanocortin (POMC) gene that encodes the precursor of adrenocorticotropic hormone (ACTH) and beta-endorphin. To control the expression of these hormones in the present study, a promoter that is inducible by administration of tetracycline derivatives such as doxycycline (Dox) was linked to the POMC gene. Encapsulated cells in the CSF space of rats stimulated by four intraperitoneal doses of Dox responded with ACTH expression as determined in a subsequence 36-hr in vitro incubation. The amount of ACTH released was dependent on the in vivo Dox dose. These findings indicate that gene expression in xenogeneic cells in the CSF space can be manipulated by injection of a relatively innocuous drug, and suggest that this system may be applicable to cell transplantation therapy in patients with central nervous system diseases that require temporary control of ligand delivery.
Optically controlled three-dimensional rotation of microscopic objects (2003)

We demonstrate that microscopic objects held in optical tweezers can be set into controlled rotation about any axis of choice. Our approach relies on the use of a spatial light modulator to create a pair of closely separated optical traps holding different parts of the same object. The pair of traps can be made to revolve around each other in any plane, rotating the trapped object with them. This technique overcomes the previous restriction on the orientation of the rotation axis to be parallel to the beam axis, and extends the versatility of optical tweezers as micromanipulation tools.
Dark-field scattering microscopy for spectral characterization of polystyrene aggregates (2010)

Light scattering measurements of particle aggregates contain complex information which is difficult to decrypt. Dark-field scattering microscopy in the visible range is used to characterize multi-arranged polystyrene beads. First, measured light scattering spectra of single spheres are compared with the Mie theory. Then, additional spectral measurements of three different sample sets of sphere aggregates are carried out. The aggregates consist of homogeneous spheres and differ in number of spheres, arrangement and contact area. Principal component analysis is used to reduce the number of variables and achieve an accurate classification regarding the aggregate characteristics.
Modulation of GSK-3β Activity in Venezuelan Equine Encephalitis Virus Infection (2012)

Alphaviruses, including Venezuelan Equine Encephalitis Virus (VEEV), cause disease in both equine and humans that exhibit overt encephalitis in a significant percentage of cases. Features of the host immune response and tissue-specific responses may contribute to fatal outcomes as well as the development of encephalitis. It has previously been shown that VEEV infection of mice induces transcription of pro-inflammatory cytokines genes (e.g., IFN-c, IL-6, IL-12, iNOS and TNF-a) within 6 h. GSK-3b is a host protein that is known to modulate pro-inflammatory gene expression and has been a therapeutic target in neurodegenerative disorders such as Alzheimer's. Hence inhibition of GSK-3b in the context of encephalitic viral infections has been useful in a neuroprotective capacity. Small molecule GSK-3b inhibitors and GSK-3b siRNA experiments indicated that GSK-3b was important for VEEV replication. Thirty-eight second generation BIO derivatives were tested and BIOder was found to be the most potent inhibitor, with an IC 50 of ,0.5 mM and a CC 50 of .100 mM. BIOder was a more potent inhibitor of GSK-3b than BIO, as demonstrated through in vitro kinase assays from uninfected and infected cells. Size exclusion chromatography experiments demonstrated that GSK-3b is found in three distinct complexes in VEEV infected cells, whereas GSK-3b is only present in one complex in uninfected cells. Cells treated with BIOder demonstrated an increase in the anti-apoptotic gene, survivin, and a decrease in the pro-apoptotic gene, BID, suggesting that modulation of pro-and anti-apoptotic genes contributes to the protective effect of BIOder treatment. Finally, BIOder partially protected mice from VEEV induced mortality. Our studies demonstrate the utility of GSK-3b inhibitors for modulating VEEV infection.
Interledger Approaches (2019)

While blockchains and more generally distributed ledger technologies (DLTs) are passing over their hype curve peak, their shortcomings are becoming more apparent. One relatively recent approach to address their performance, scalability, privacy, and other problems are to use multiple different DLTs instead of relying on just one. While there are no really established standards for combining several DLTs, a few repeating patterns can be observed. In this paper, we present a survey of interledger approaches, discussing and comparing their underlying mechanisms. A shared motivation for all of the discussed interledger solutions is to move away from the “one chain rules them all” model to one that allows the interconnection of multiple ledgers, with different features and advantages, while also supporting innovation. The interledger approaches discussed in this survey include (1) atomic cross-chain transactions, (2) transactions across a network of payment channels, (3) the W3C Interledger Protocol (ILP), (4) bridging, (5) sidechains, and (6) ledger-of-ledgers. The approaches are compared according to whether they support the transfer or the exchange of value, their interconnection trust mechanism, complexity, scalability, and transaction cost.
Server selection for carbon emission control (2011)

Cloud owners are allowing their users to specify the level of resources being used in the different geographical locations that make up the cloud. The carbon emissions caused by powering these resources can vary greatly between different geographical regions. The traffic for a given service can come from anywhere on the planet and the further the request has to travel the greater the negative effect on quality of service (QoS). It is desirable to route traffic to the resources which cause the lowest carbon emissions but this can affect the QoS. A framework that characterizes this trade-off between carbon emissions and QoS is established in this paper. An algorithm that attempts to minimize the total cost of the trade-off described is presented. A traffic generator is used to generate load for a server to establish functions which detail the carbon emissions and QoS of a service. We use these functions to simulate the performance of the algorithm in minimizing the total cost. Our results imply that carbon emissions can be reduced with little effect on the QoS under static traffic conditions and favourable energy supply conditions.
Device control using gestures sensed from EMG (2003)

In this paper, we present neuro-electric interfaces for virtual device control. The examples presented rely upon sampling electromyogram data from a participant's forearm. This data is then set into pattern recognition software that had been trained to distinguish gestures from a given gesture set. The pattern recognition software consists of hidden Markov models, which are used to recognize the gestures as they are being performed in real-time. two experiments were conducted to examine the feasibility of this interface technology. The first replicate a virtual joystick interface and the second replicated a keyboard.
Alternative Phrases Theoretical Analysis and Practical Application (2001)

All right, but apart from the sanitation, the medicine, education, wine, public order, irrigation, roads, the fresh-water system and public health, what have the Romans ever done for us? (Monty Python, The Life of Brian) Alternative phrases identify selected elements from a set and subject them to particular scrutiny with respect to the sentence&apos;s predicate. For instance, in the above example, sanitation, medicine, etc. are all identified as elements in the set of things &quot;the Romans have done for us&quot; that should not be included in the response to the question. They are alternative responses to the desired ones. Alternative phrases come in a variety of constructions and perform a variety of tasks: excluding elements (apart from), expressing preference for particular elements (especially), and simply identifying representative examples (such as).
<i>In situ</i> x-ray diffraction study of the role of annealing ambient in epitaxial CoSi2 growth from Co/Ti bilayers on Si(001) (1995)

The reactions during annealing of a Co/Ti bilayer structure on Si(001) were studied in situ to reveal the roles of the Ti interlayer and the annealing ambient on the formation of epitaxial CoSi2. We shown that an oxygen contaminant in the nitrogen annealing gas is needed to form a stable, Co–Ti–O (spinel) membrane at the metal/Si interface that limits diffusion and is crucial for the perfection of epitaxial CoSi2. Annealing in vacuum or otherwise inert environments led to polycrystalline CoSi2 films and no spinel phase.
Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling (2007)

Bone morphogenetic protein-2 (BMP-2) has been proposed as a tool for cartilage repair and as a stimulant of chondrogenesis. In healthy cartilage, BMP-2 is hardly present, whereas it is highly expressed during osteoarthritis. To assess its function in cartilage, BMP-2 was overexpressed in healthy murine knee joints and the effects on proteoglycan (PG) synthesis and degradation were evaluated. Moreover, the contribution of BMP in repairing damage induced by interleukin-1 (IL-1) was investigated. Ad-BMP-2 was injected intra-articularly into murine knee joints, which were isolated 3, 7, and 21 days after injection for histology, immunohistochemistry, and autoradiography. In addition, patellar and tibial cartilage was isolated for RNA isolation or measurement of PG synthesis by means of 35SO4(2-) incorporation. To investigate the role for BMP-2 in cartilage repair, cartilage damage was induced by intra-articular injection of IL-1. After 2 days, Ad-BMP-2, Ad-BMP-2 + Ad-gremlin, Ad-gremlin, or a control virus was injected. Whole knee joints were isolated for histology at day 4 or patellae were isolated to measure 35SO4(2-) incorporation. BMP-2 stimulated PG synthesis in patellar cartilage on all days and in tibial cartilage on day 21. Aggrecan mRNA expression had increased on all days in patellar cartilage, with the highest increase on day 7. Collagen type II expression showed a similar expression pattern. In tibial cartilage, collagen type II and aggrecan mRNA expression had increased on days 7 and 21. BMP-2 overexpression also induced increased aggrecan degradation in cartilage. VDIPEN staining (indicating matrix metalloproteinase activity) was elevated on day 3 in tibial cartilage and on days 3 and 7 in patellar cartilage, but no longer was by day 21. Increased NITEGE staining (indicating aggrecanase activity) was found on days 7 and 21. In IL-1-damaged patellar cartilage, BMP-2 boosted PG synthesis. Blocking of BMP activity resulted in a decreased PG synthesis compared with IL-1 alone. This decreased PG synthesis was associated with PG depletion in the cartilage. These data show that BMP-2 boosts matrix turnover in intact and IL-damaged cartilage. Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix.
Diode cascade quantum well VCSEL (2002)

Summary form only. In the present study we investigate diode cascade structures containing two active InGaAs quantum well layer VCSELs connected by a modulation doped backward tunnel diode. This approach of applying several diodes in series may potentially lead to a threshold current close to the transparency current and provide high differential gain but requires an enlarged operating voltage depending on the number of pn-junctions employed.
Normalization of Analog Horizontal Wells for Type Curve Generation in Tight Gas Plays (2015)

Abstract A mature reservoir is usually characterized with a number of both vertical and horizontal wells, which may both contribute to a significant recovery to-date. When considering forecasting for new wells in the geological similar areas (GSAs), it is common practice to generate a type curve by harnessing historical production data from analog wells. But, given varying well types and completion practices (e.g. different horizontal wellbore length), the analog assumption may be challenged. When working on type curve generation, the common questions frequently asked are:Do we need to normalize analog wells for the type curve generation?How to conduct the normalization on both wellbore length and completion parameters? It seems that the answer to the first question is a very obvious yes if the new wells will be designed differently from the analog wells – particularly if the lateral length and completion method is not similar. As a result, Estimated Ultimate Recoveries (EURs) and the Initial Production (IPs) will need to be normalized from those analog wells to a desired new wellbore length. After having investigated both analytically and numerically the impacts on Recovery Factors (RFs) and the IPs from those factors of horizontal wells that include horizontal wellbore length (L), fracturing spacing/stages (nf) and drainage area (A), or well spacing, it is found that: RF will be directly affected by the wellbore length. There is linearity between RF and L when the latter is less than a certain value. The fracturing spacing/stages and drainage area (well spacing), however, will affect RF when the reservoir matrix permeability is extremely low.Also, IP has a high positive correlation with lateral length. In fact, these two variables have high linearity. In addition, fracture spacing will have a large impact on IP rates; however, drainage area will not at all. Note that these conclusions presume that wellbore hydraulic considerations are not a constraint. Further, lateral length presumes an effectively stimulated horizontal section. The specific scope of this study is to provide a systematic normalization technique. Dry gas and wet gas case studies from the Western Canadian Sedimentary Basin (WCSB) have been adopted to demonstrate the workflow. Further, sequential accumulation statistical logic has been successfully applied to validate the premise of lateral length and fracture spacing as the key normalization variables. It is believed that this methodology is rigorous for dry and wet gas reservoir systems. Moreover, this methodology is also applicable to richer gas-condensate and oil plays; however, broader relationships need to be established and tested before any conclusions can be drawn with wellbore hydraulic dynamics being taking into account as an effective factor.
A colony color method which differentiates alpha galactosidase positive strains of yeast (1986)

Mise au point d'un milieu gelose contenant comme substrat chromogene du bromo-5-chloro-4-indolyl-3 α-D-galactoside permettant d'identifier les differentes souches de Saccharomyces cerevisiae et S. uvarum
Functional characterization of recombinant batroxobin, a snake venom thrombin‐like enzyme, expressed from <i>Pichia pastoris</i> (2004)

A thrombin-like enzyme of Bothrops atrox moojeni venom, batroxobin, specifically cleaves fibrinogen alpha chain, resulting in the formation of non-crosslinked fibrin clots. The cDNA encoding batroxobin was cloned, expressed in Pichia pastoris and the molecular function of purified recombinant protein was also characterized. The recombinant batroxobin had an apparent molecular weight of 33 kDa by SDS-PAGE analysis and biochemical activities similar to those of native batroxobin. The purified recombinant protein strongly converted fibrinogen into fibrin clot in vitro, and shortened bleeding time and whole blood coagulation time in vivo. However, it did not make any considerable alterations on other blood coagulation factors. Several lines of experimental evidence in this study suggest that the recombinant batroxobin is a potent pro-coagulant agent.
The 5′-Flanking Region of the Mouse Adenylyl Cyclase Type VIII Gene Imparts Tissue-Specific Expression in Transgenic Mice (1999)

The calcium-stimulated adenylyl cyclases (ACs) play a central role in stimulus-dependent modification of synaptic function. The type VIII AC (AC8) is one of three mammalian calcium-stimulated isoforms, each of which is expressed in a region-specific manner in the CNS. To delineate the DNA sequences responsible for appropriate targeting of AC8 expression, we report here the complete structure of the AC8 gene and define the pattern of expression of the full-length cDNA and its splice variants. In addition to expression within the brain, robust expression of AC8 was also found in the lung. By in situ hybridization, we have found the highest expression of AC8 mRNA within the olfactory bulb, thalamus, habenula, cerebral cortex, and hypothalamic supraoptic and paraventricular nuclei. By generating transgenic mice whose expression of beta-galactosidase is controlled by the AC8 5'-flanking DNA sequences, we demonstrate that the DNA sequences within the 10 kb preceding exon 1 are critical for establishment of this region-specific pattern. This spectrum of sites of production is unique to AC8 among the calcium-stimulated adenylyl cyclases and suggests nonredundant functions with other adenylyl cyclases in neuroendocrine regulation and/or behavior.
Limits of CMOS Technology and Interest of NEMS Relays for Adiabatic Logic Applications (2015)

In this paper, a detailed analysis and comparison of nanoelectromechanical systems (NEMS) and CMOS technologies for low power adiabatic logic implementation is presented. Fundamental limits of CMOS-based adiabatic logic are identified. Analytic relations describing the energy-performance for sub-threshold adiabatic logic are also explicitly derived and optimized. The interest of combining NEMS technology and adiabatic logic is described, and the key NEMS switch parameters that govern the dissipation-performance relationship are identified as the switch commutation frequency, its actuation voltage, and the contact resistance between the switch electrodes. Furthermore, NEMS-based adiabatic gates architectures are described. Finally, the contribution of the power-clock or energy recovery generator is estimated in order to compare CMOS and NEMS-based adiabatic architectures at the system level. The paper concludes with a detailed comparison of the energy-performance of the different explored technologies.
비영리조직의 내부 거버넌스와 조직효율성 - 아시아태평양 지역의 경험과 교훈 (2004)

본 논문은 2003년 9월 필리핀에서 거버넌스, 조직효과성과 비영리 섹터라는 주제로 개최된 APPC(Asia Pacific Philanthrophy Consortium) 회의에 제출된 아시아 태평양지역의 11개 국/지역의 보고서와 그곳에서 논의된 토론의 주요 내용을 요약, 소개함으로써 우리나라 시민사회에 함의를 찾아보고자 했다. 이...
Flight assignment plan for an air cargo inbound terminal (2010)

The paper studies the modeling and optimization for the flight assignment plan for an air cargo inbound terminal. A multi-objective Mixed Integer Programming (MIP) model is formulated to determine this plan. A set of non-dominated solutions are obtained by solving this multi-objective model and they are further analyzed by a simulation model to identify the best one.
Casemix. A cross-national, casemix analysis of hospital length of stay for selected pathologies (1999)

Background: The factors which contribute to length of stay variations for hospital discharges is the focus of an expanding body of international research. Methods: The study reported here is intended to facilitate an advancement of this research as the analysis described was undertaken on a unique multinational database within which over 3.3 million cases from 12 countries have been compiled in a standardised manner. Differences in length of stay both within and between countries were assessed for over 119,400 discharges within selected high-volume pathologies classified according to three alternative measures of hospital casemix. Results: The results show that irrespective of the casemix measure applied, substantial unexplained variation in hospital length of stay persists both within and between countries for the pathologies reviewed. Conclusions: These results suggest that, in addition to standardising for casemix, future research on length of stay variation should focus on additional potentially influential factors, including health system characteristics, medical practice variation and patient behaviour and expectations.
Natural language processing (1973)

Article Free AccessNatural language processing Share on CSC '73: Proceedings of the 1st annual computer science conference on Program information abstractsFebruary 1973 Pages 54–55https://doi.org/10.1145/1125118.1125149Online:20 February 1973Publication History 0citation78DownloadsMetricsTotal Citations0Total Downloads78Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Effects of Wet Cleaning on Si Contaminated with Heavy Metals during Reactive Ion Etching (1985)

Heavy metal removal from Si wafers contaminated during reactive ion etching (RIE) is studied using wet cleaning techniques, Si wafers are intentionally contaminated during RIE with Fe, Cr, or Ni, which are atomic components of stainless steel, the material used in dry etching apparatus. The Si wafers are washed with several reagents, and heavy metal removal results are estimated using secondary ion mass spectrometry and stacking fault observation. The results show that Fe and Cr are removed by wet etching the Si wafers to approximately a 30 nm depth but that Ni cannot be removed. The results indicate that to protect Si wafers against heavy metal contamination during RIE, Ni‐free materials should be used for fixtures in the dry etching chamber.