gebhart/patrepeval huggingface dataset:
Rho GTPases, dendritic structure, and mental retardation (2005)

A consistent feature of neurons in patients with mental retardation is abnormal dendritic structure and/or alterations in dendritic spine morphology. Deficits in the regulation of the dendritic cytoskeleton affect both the structure and function of dendrites and synapses and are believed to underlie mental retardation in some instances. In support of this, there is good evidence that alterations in signaling pathways involving the Rho family of small GTPases, key regulators of the actin and microtubule cytoskeletons, contribute to both syndromic and nonsyndromic mental retardation disorders. Because the Rho GTPases have been shown to play increasingly well-defined roles in determining dendrite and dendritic spine development and morphology, Rho signaling has been suggested to be important for normal cognition. The purpose of this review is to summarize recent data on the Rho GTPases pertaining to dendrite and dendritic spine morphogenesis, as well as to highlight their involvement in mental retardation resulting from a variety of genetic mutations within regulators and effectors of these molecules.
Fusion of double layered multiple laser range finders for people detection from a mobile robot (2008)

This work proposes a new method people detection and position estimation from a mobile robot by fusion of multiple laser range finders arranged in two layers. Sensors facing opposite directions in a single row (layer) are fused to produce 360deg scan data of robotpsilas surroundings, then data from every layer is further fused to create a 3D model of people and from there their position. The main problem of our research is an autonomous mobile robot acting as member of a people group moving in public areas, simple and accurate people detection and tracking is an important requirement. We present experimental results of fusion steps and people detection in an indoor environment.
Robo1-specific CAR-NK Immunotherapy Enhances Efficacy of <sup>125</sup>I Seed Brachytherapy in an Orthotopic Mouse Model of Human Pancreatic Carcinoma (2019)

Robo1 specific CAR-NK immunotherapy enhances efficacy of <sup>125</sup>I seed brachytherapy in an orthotopic pancreatic cancer mouse model.
Color lensless digital holographic microscopy with micrometer resolution (2012)

Color digital lensless holographic microscopy with micrometer resolution is presented. Multiwavelength illumination of a biological sample and a posteriori color composition of the amplitude images individually reconstructed are used to obtain full-color representation of the microscopic specimen. To match the sizes of the reconstructed holograms for each wavelength, a reconstruction algorithm that allows for choosing the pixel size at the reconstruction plane independently of the wavelength and the reconstruction distance is used. The method is illustrated with experimental results.
Legacy Information Systems and Business Process Change: A Patterns Perspective (1999)

Integration of technical systems with business processes, and coherent strategies for the development of both, have long been recognised as critical to the competitiveness of companies. However, as separate systems become integrated, dependencies are established that complicate future reengineering exercises. These internal dependencies increase the risk associated with change, promote incremental approaches to systems reengineering and hasten the emergence of legacy systems. Once established, these legacy systems not only represent an impediment to advancing the technology strategy, they may also lock in redundant business processes with a consequent erosion of competitiveness. Reengineering these legacy systems to improve competitiveness therefore requires both technical expertise in systems engineering and an understanding of what the business process is intended to achieve. Recent technical and business change drivers such as the 'Year 2000 Problem' (Y2K) and Economic and Monetary Union (EMU), however, exposed concerns that many organisations may lack even the required technical expertise. Clearly a demand for improving the capture and dissemination of systems reengineering expertise exists. One recent and promising approach to allowing transfer of expertise in well-defined contexts uses patterns. This paper explores patterns as a means of codifying and disseminating systems reengineering expertise. Through widening the definition of a legacy system to include the business process, we propose that patterns may provide a communication link between business and technology strategists that would help align their objectives and improve the sustainability of any resulting competitive advantage.
Structural insights into the YAP and TEAD complex (2010)

The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50-171)-TEAD1 (residues 194-411) complex, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces. Interface 3, including YAP residues 86-100, is most critical for complex formation. Our study reveals the biochemical nature of the YAP-TEAD interaction, and provides a basis for pharmacological intervention of YAP-TEAD hyperactivation in human diseases.
Modelling the predicted geographic and economic response of UK cropping systems to climate change scenarios: the case of sugar beet (1998)

Summary. Geographical changes in suitability for the cultivation of sugar beet in England and Wales were predicted for climate change scenarios for 2023 and 2065 by integrating a climate database (1951‐80) with climate‐driven crop growth models. Initially, the outputs were produced as point values (at meteorological site locations) of predicted potential yields for current production. The outputs were validated statistically using actual crop yield figures collated from bibliographic analysis. The most suitable model was run again incorporating projected temperature and precipitation changes for 2023 and 2065. The outputs were mapped using a Geographical Information System and used to predict possible economic changes in farm profitability (and general market trends). Results indicated that the area of suitability for the growth of the crop moves westward with an increase in production in the West Midlands of approximately 5% (2 t ha ‐1 fresh weight) by 2023 and 13% (6 t ha ‐1 fresh weight) by 2065. The reduction in production in East Anglia coupled with the increase in production in the West does not align well with the current location of processing factories
Transmission power control based on packet reception rate (2014)

This paper proposes and analyses properties of transmission power control mechanism for Wireless Sensor Networks based on estimated packet reception rate. The algorithm is dedicated for low power wireless networks and its aim is to minimise average cost of radio transmission, reduce retransmissions and interferences between network nodes.
Mid-infrared angled-grating distributed feedback laser (2000)

We report near-diffraction-limited output from an angled-grating distributed feedback type-II W laser emitting near 3.4 μm. For pulsed optical pumping of a 50-μm-wide stripe at 78 K, the far-field beam divergence angle was only 1.4°. The slope efficiency was 64% of that for a conventional Fabry–Pérot laser on the same bar. However, the spectral linewidth decreased by only a factor of 2. The beam quality was substantially better than that for the Fabry–Pérot laser out to stripe widths of at least 800 μm.
Synthesis of Potential Anticancer Agents. XXVIII. Simple Esters of 6-Mercaptopurine Ribonucleotide<sup>2</sup> (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Potential Anticancer Agents. XXVIII. Simple Esters of 6-Mercaptopurine Ribonucleotide2JOHN A. MONTGOMERY, H. JEANETTE THOMAS, and HOWARD J. SCHAEFFERCite this: J. Org. Chem. 1961, 26, 6, 1929–1933Publication Date (Print):June 1, 1961Publication History Published online1 May 2002Published inissue 1 June 1961https://pubs.acs.org/doi/10.1021/jo01065a058https://doi.org/10.1021/jo01065a058research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiclass semantic video segmentation with object-level active inference (2015)

We address the problem of integrating object reasoning with supervoxel labeling in multiclass semantic video segmentation. To this end, we first propose an object-augmented dense CRF in spatio-temporal domain, which captures long-range dependency between supervoxels, and imposes consistency between object and supervoxel labels. We develop an efficient mean field inference algorithm to jointly infer the supervoxel labels, object activations and their occlusion relations for a moderate number of object hypotheses. To scale up our method, we adopt an active inference strategy to improve the efficiency, which adaptively selects object subgraphs in the object-augmented dense CRF. We formulate the problem as a Markov Decision Process, which learns an approximate optimal policy based on a reward of accuracy improvement and a set of well-designed model and input features. We evaluate our method on three publicly available multiclass video semantic segmentation datasets and demonstrate superior efficiency and accuracy.
Reflections on the Final Volume of The Oxford History of English Literature (1965)

Journal Article REFLECTIONS ON THE FINAL VOLUME OF THE OXFORD HISTORY OF ENGLISH LITERATURE Get access HARRY LEVIN HARRY LEVIN Harvard Search for other works by this author on: Oxford Academic Google Scholar Forum for Modern Language Studies, Volume I, Issue 1, January 1965, Pages 4–16, https://doi.org/10.1093/fmls/I.1.4 Published: 01 January 1965
Experimental characterisation of an open out-of-home MHP-based DVR service (2010)

MHP (Multimedia Home Platform) is an open standard for interactive TV middleware that was designed by the Digital Video Broadcasting (DVB) alliance and is found on many commercially deployed set-top boxes (STBs).In this paper, a detailed system architecture is presented which enables customers of digital television providers to use their MHPbased DVR from an out-of-home location through their mobile phone.Building further on the openness of the MHP platform, special focus was on the overall scalability, security and extensibility of the system and the efficient and fast communication between mobile phone and set-top box.Technical challenges are imposed by the limited hardware resources that are available on most of the currently deployed STBs and by the delays that are introduced by the mobile communication networks.In order to characterise the system's performance, extensive throughput and scalability tests were performed on commercial DVRs.It is shown that the overall system performance meets the predefined requirements even under heavy load.
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin (2009)

The thiazolylpeptides are a family of >50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis. Here, we report a biosynthetic gene cluster for thiocillin and establish that it, and by extension the whole class, is ribosomally synthesized. Remarkably, the C-terminal 14 residues of a 52-residue peptide precursor undergo 13 posttranslational modifications to give rise to thiocillin, making this antibiotic the most heavily posttranslationally-modified peptide known to date.
Privacy-Preserving Protocols for Shortest Path Discovery over Outsourced Encrypted Graph Data (2015)

Outsourcing data and computation to the cloud is increasingly common. However, the data to be outsourced is often privacy-sensitive (e.g., geospatial data, social network data, and Internet network traffic data) and thus it is typically outsourced after being properly encrypted. Graph is one of the most common ways to model and represent the data in many applications, including geospatial data in geographic information systems. In this paper, we consider the following problem: given a graph G, representing for example road or social networks, outsourced to a cloud in encrypted format, the user wants to privately retrieve from G the shortest path from a source s to a destination t. We refer to this problem as Privacy-preserving Shortest Path discovery over Encrypted Graph (PSPEG) data. We propose two novel PSPEG protocols under different security and efficiency guarantees. The first protocol enables one to retrieve the shortest path under a single-cloud setting whereas the second protocol is proposed under a federated cloud environment. Our theoretical and empirical analyses show that the proposed protocols provide a trade-off between efficiency and security.
Cell-to-Cell and Long-Distance Transport of Viruses in Plants (1996)

James C. Carrington, Kristin D. Kasschau, Sunita K. Mahajan, Mary C. Schaad, Cell-to-Cell and Long-Distance Transport of Viruses in Plants, The Plant Cell, Vol. 8, No. 10, Special Review Issue on Plant-Microbe Interactions (Oct., 1996), pp. 1669-1681
Combination of long- and short-axis alar sacroplasty techniques under fluoroscopic guidance for osteoporotic sacral insufficiency fracture (2021)

A combination of long- and short-axis alar sacroplasty techniques can be effectively performed under fluoroscopic guidance for osteoporotic SIFs.
Simulation of nonGaussian long-range-dependent traffic using wavelets (1999)

Article Free Access Share on Simulation of nonGaussian long-range-dependent traffic using wavelets Authors: Vinay J. Ribeiro Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TX Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TXView Profile , Rudolf H. Riedi Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TX Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TXView Profile , Matthew S. Crouse Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TX Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TXView Profile , Richard G. Baraniuk Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TX Department of Electrical and Computer Engineering, Rice University, 6100 South Main Street, Houston, TXView Profile Authors Info & Claims SIGMETRICS '99: Proceedings of the 1999 ACM SIGMETRICS international conference on Measurement and modeling of computer systemsMay 1999 Pages 1–12https://doi.org/10.1145/301453.301475Published:01 May 1999Publication History 27citation549DownloadsMetricsTotal Citations27Total Downloads549Last 12 Months13Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Real-time Fluorescence Imaging of Capillary Electrophoresis (1995)

An arrangement for real-time fluorescence imaging of capillary electrophoretic separations is described. A decoated capillary was excited along a substantial part of its length by a dye laser pumped with an XeCl excimer laser tuned to match the fluorophors in the sample. Light emitted from the migrating, fluorescent molecules was detected by an image-intensified, thermoelectrically cooled charge-coupled device camera. The camera signals were processed by a computer and displayed as moving peaks on a screen in real-time, thus allowing the progress of the separation to be monitored continuously. Basic characteristics of the imaging arrangement such as sensitivity (signal-to-noise ratio) and resolution were checked with fluorescein samples. The imaging principle was also illustrated with a separation of a mixture of DNA fragments on a commercially available capillary designated for DNA separations. The benefits of real-time imaging for separation processes, in particular for capillary electrophoresis, are discussed.
Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species (2003)

Polypeptide deformylase (PDF) catalyzes the deformylation of polypeptide chains in bacteria. It is essential for bacterial cell viability and is a potential antibacterial drug target. Here, we report the crystal structures of polypeptide deformylase from four different species of bacteria: Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Comparison of these four structures reveals significant overall differences between the two Gram-negative species (E. coli and H. influenzae) and the two Gram-positive species (S. pneumoniae and S. aureus). Despite these differences and low overall sequence identity, the S1' pocket of PDF is well conserved among the four enzymes studied. We also describe the binding of nonpeptidic inhibitor molecules SB-485345, SB-543668, and SB-505684 to both S. pneumoniae and E. coli PDF. Comparison of these structures shows similar binding interactions with both Gram-negative and Gram-positive species. Understanding the similarities and subtle differences in active site structure between species will help to design broad-spectrum polypeptide deformylase inhibitor molecules.
Solutions for Processing K Nearest Neighbor Joins for Massive Data on MapReduce (2015)

Given a point p and a set of points S, the kNN operation finds the k closest points to p in S. It is a computational intensive task with a large range of applications such as knowledge discovery or data mining. However, as the volume and the dimension of data increase, only distributed approaches can perform such costly operation in a reasonable time. Recent works have focused on implementing efficient solutions using the MapReduce programming model because it is suitable for large scale data processing. Also, it can easily be executed in a distributed environment. Although these works provide different solutions to the same problem, each one has particular constraints and properties. There is no readily available comparison to help users choose the one most appropriate for their needs. This is the problem we address in this work. Firstly, we show that all kNN implementations go through a common workflow, which we use as a basis for classification. Secondly, we describe precisely the different techniques published so far. And lastly, we provide a set of objective criteria that can be used to make informed decisions.
Self adaptation of mutation rates in a steady state genetic algorithm (2002)

This paper investigates the use of genetically encoded mutation rates within a "steady state" genetic algorithm in order to provide a self-adapting mutation mechanism for incremental evolution. One of the outcomes of this work will be a reduction in the number of parameters required to be set by the operator, thus facilitating the transfer of evolutionary computing techniques into an industrial setting. The NK family of landscapes is used to provide a variety of different problems with known statistical features in order to examine the effects of changing various parameters on the performance of the search. A number of policies are considered for the replacement of members of the population with newly created individuals and recombination of material between parents, and a number of methods of encoding for mutation rate are investigated. Empirical comparisons (using the "best-of current-population" metric) over a range of test problems show that a genetic algorithm incorporating the best "flavour" of the adaptive mutation operator outperformed the same algorithm when using any one of a variety of "standard" fixed mutation rates suggested by other authors.
Vesicular Stomatitis Virus M Protein Mutant Stimulates Maturation of Toll-Like Receptor 7 (TLR7)-Positive Dendritic Cells through TLR-Dependent and -Independent Mechanisms (2009)

Wild-type (wt) vesicular stomatitis virus (VSV) strains stimulate plasmacytoid dendritic cells (pDC) through Toll-like receptor 7 (TLR7) and its adaptor molecule, MyD88. Granulocyte-macrophage colony-stimulating factor-derived DC (G-DC), which do not express TLR7, are unresponsive to wt VSV due to inhibition of cellular gene expression by the matrix (M) protein. In contrast to its recombinant wt (rwt) counterpart, an M protein mutant of VSV, rM51R-M virus, stimulates maturation of G-DC independently of MyD88. These results suggest that, as in the case of G-DC, rM51R-M virus may stimulate pDC by mechanisms distinct from that by rwt virus. Studies presented here demonstrate that both rwt and rM51R-M viruses induced maturation of TLR7-positive DC derived by culture in the presence of Flt3L (F-DC), with the subsequent expression of type I interferon (IFN). F-DC are a mixture of myeloid (CD11b(+)) and plasmacytoid (B220(+)) DC, both of which respond to TLR7 ligands. Separated CD11b(+) and B220(+) F-DC responded to both rwt and rM51R-M viruses. Both viruses were also defective at inhibiting host gene expression in F-DC, including the expression of genes involved in the antiviral response. The data from F-DC generated from IFN receptor knockout mice demonstrated that the maturation of F-DC induced by rwt virus was dependent on the type I IFN response, while maturation induced by rM51R-M virus was partially dependent on this molecule. Therefore, activation of the type I IFN pathway appears to be important for not only inducing an antiviral response but also for stimulating maturation of F-DC upon virus infection. Importantly, F-DC from TLR7 and MyD88 knockout mice did not undergo maturation in response to rwt virus, while maturation induced by rM51R-M virus was largely independent of both molecules. These results indicate that although both viruses induce F-DC maturation, F-DC detect and respond to rM51R-M virus by means that are distinct from rwt virus. Specifically, this mutant virus appears capable of inducing DC maturation in a wide variety of DC subsets through TLR-dependent and independent mechanisms.