gebhart/patrepeval huggingface dataset:
Mass Spectrometric Identification of Human Prostate Cancer-derived Proteins in Serum of Xenograft-bearing Mice (2006)

Lack of sensitivity and specificity of current tumor markers has intensified research efforts to find new biomarkers. The identification of potential tumor markers in human body fluids is hampered by large variability and complexity of both control and patient samples, laborious biochemical analyses, and the fact that the identified proteins are unlikely produced by the diseased cells but are due to secondary body defense mechanisms. In a new approach presented here, we eliminate these problems by performing proteomic analysis in a prostate cancer xenograft model in which human prostate cancer cells form a tumor in an immune-incompetent nude mouse. Using this concept, proteins present in mouse serum that can be identified as human will, by definition, originate from the human prostate cancer xenograft and might have potential diagnostic and prognostic value. Using one-dimensional gel electrophoresis, liquid chromatography, and mass spectrometry, we identified tumor-derived human nm23/nucleoside-diphosphate kinase (NME) in the serum of a nude mouse bearing the androgen-independent human prostate cancer xenograft PC339. NME is known to be involved in the metastatic potential of several tumor cells, including prostate cancer cells. Furthermore we identified six human enzymes involved in glycolysis (fructose-bisphosphate aldolase A, triose-phosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, alpha enolase, and lactate dehydrogenases A and B) in the serum of the tumor-bearing mice. The presence of human NME and glyceraldehyde-3-phosphate dehydrogenase in the serum of PC339-bearing mice was confirmed by Western blotting. Although the putative usefulness of these proteins in predicting prognosis of prostate cancer remains to be determined, the present data illustrate that our approach is a promising tool for the focused discovery of new prostate cancer biomarkers.
Hybrid Achromatic Objective Lens Design For Optical Data Storage (1993)

As higher power laser diodes are incorporated into optical data storage systems, wavelength shifts of several nanometers can occur between read and write powers, which demands that some attention be given to the chromatic correction of the optical system. This paper presents the design of a hybrid objective lens that is chromatically corrected by the addition of a diffractive element to the second surface of the lens. It is low mass, small size, and provides high Strehl Ratio performance. A 0.47 N.A. hybrid objective lens corrected for monochromatic aberrations has been discussed previously by Goto et al.
Managing group membership in ad hoc m-commerce trading systems (2010)

Managing group membership in an ad hoc m-commerce trading forum is a challenging task as peers may only have partial knowledge of the current membership due to frequent network disconnections, infrequent participation and delays in communication via intermediaries among them The absence of a centralized network infrastructure adds more complexity to this problem This paper presents a fully distributed and self-organizing approach to managing group membership in such a loose trading community. It is designed to suit the dynamic nature of ad hoc wireless networking and the social characteristics of ad hoc m-commerce.
Educating Medical Office Staff: Enhancing Diabetes Care in Primary Care Offices (2006)

In Brief This article describes Joslin Diabetes SmartStart, a program through which the provision of educational materials and training to the office staff of primary care providers has resulted in improved clinical and behavioral patient outcomes. Certified diabetes educators provided participating clinics with basic diabetes education for clinical staff; a set of diabetes patient education flipcharts, booklets, and handouts in English and Spanish; and patient access to a call center. Positive outcomes included decreases in hemoglobin A1c and blood pressure levels and increases in patient-reported quality of life and confidence in diabetes self-management ability.
Growth of an epitaxial insulator-metal-semiconductor structure on Si by molecular beam epitaxy (1986)

We report the first successful growth of an epitaxial insulator-metal-semiconductor structure. The substrate is Si (111), on which a layer of CoSi2 followed by a layer of CaF2 have been grown by molecular beam epitaxy. The epitaxy of the top CaF2 layer improves upon rapid thermal annealing. The epitaxial relations of the two overlayers with respect to the substrate have been determined. The lattice of the CoSi2 is rotated 180° with respect to the Si lattice, while the CaF2 is aligned with the Si lattice. This work demonstrates that it is possible to combine these materials in a single heteroepitaxial structure and may have important applications in three-dimensional integration.
Single logical view over enterprise-wide distributed databases (1993)

Two trends in today's corporate world demand distribution: downsizing from centralized mainframe single database environments; and wider integration, connecting finance, engineering, manufacturing information systems for enterprise-wide modeling and operations optimization. The resulting environment consists of multiple databases, at the group level, department level, and corporate level, with the need to manage dependencies among data in all of them. The solution is full distribution, providing a single logical view to objects anywhere, from anywhere. Users see a logical model of objects connected to objects, with atomic transactions and propagating methods, even if composite objects are split among multiple databases, each under separate administrative control, on multiple, heterogeneous platforms, operating systems, and network protocols. Support for production environments includes multiple schemas, which may be shared among databases, private, or encrypted, dynamic addition of schemas, and schema evolution. Finally, the logical view must remain valid, and applications must continue to work, as the mapping to the physical environment changes, moving objects and databases to new platforms.
Progress in Induction Synchrotron R&D: First Result of Induction Acceleration in the KEK Proton Synchrotron (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ken Takayama, Super‐bunch Group; Progress in Induction Synchrotron R&D: First Result of Induction Acceleration in the KEK Proton Synchrotron. AIP Conf. Proc. 8 June 2005; 773 (1): 281–285. https://doi.org/10.1063/1.1949546 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
L’Adoption : droits et pratiques (1998)

Ce dossier explore les formes et pratiques de l'adoption dans l'Occident medieval, adoption presente dans le droit romain comme dans le droit barbare. Sont abordees les questions suivantes : l'adoption dans le droit merovingien et dans le droit byzantin ; la signification de l'adoptio dans la societe chretienne medievale (analyse semantique, adoption humaine et divine, adoption et structures de parente, parente spirituelle) ; aristotelisme et importance du droit du sang dans la pensee juridique medievale relative a la filiation adoptive ; l'adoption dans les textes juridiques espagnols et son role dans les strategies familiales (continuite familiale, heritage) de la noblesse espagnole ; l'importance des formes lâches d'adoption (notamment le fosterage) et la primaute du droit du sang a Florence ; la pratique de la donation d'enfants et de la reception des bâtards en Gevaudan ; deux transcriptions d'actes concernant l'adoption en Sicile et dans le Gevaudan.
Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation (2009)

The first metal complexes of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine) were synthesized. Triapine was prepared by a novel three-step procedure in 64% overall yield. In addition, a series of related ligands, namely, 2-formylpyridine thiosemicarbazone, 2-acetylpyridine thiosemicarbazone, 2-pyridineformamide thiosemicarbazone, and their N(4)-dimethylated derivatives (including the N(4)-dimethylated analogue of Triapine) were prepared, along with their corresponding gallium(III) and iron(III) complexes with the general formula [M(L)(2)](+), where HL is the respective thiosemicarbazone. The compounds were characterized by elemental analysis, (1)H and (13)C NMR, IR and UV-vis spectroscopies, mass spectrometry, and cyclic voltammetry. In addition, Triapine and its iron(III) and gallium(III) complexes were studied by X-ray crystallography. All ligands and complexes were tested for their in vitro antiproliferative activity in two human cancer cell lines (41M and SK-BR-3), and structure-activity relationships were established. In general, the coordination to gallium(III) increased the cytotoxicity while the iron(III) complexes show reduced cytotoxic activity compared to the metal-free thiosemicarbazones. Selected compounds were investigated for the capacity of inhibiting ribonucleotide reductase by incorporation of (3)H-cytidine into DNA.
Convergent microRNA actions coordinate neocortical development (2014)

Neocortical development is a complex process that, at the cellular level, involves tight control of self-renewal, cell fate commitment, survival, differentiation and delamination/migration. These processes require, at the molecular level, the precise regulation of intrinsic signaling pathways and extrinsic factors with coordinated action in a spatially and temporally specific manner. Transcriptional regulation plays an important role during corticogenesis; however, microRNAs (miRNAs) are emerging as important post-transcriptional regulators of various aspects of central nervous system development. miRNAs are a class of small, single-stranded noncoding RNA molecules that control the expression of the majority of protein coding genes (i.e., targets). How do different miRNAs achieve precise control of gene networks during neocortical development? Here, we critically review all the miRNA-target interactions validated in vivo, with relevance to the generation and migration of pyramidal-projection glutamatergic neurons, and for the initial formation of cortical layers in the embryonic development of rodent neocortex. In particular, we focus on convergent miRNA actions, which are still a poorly understood layer of complexity in miRNA signaling, but potentially one of the keys to disclosing how miRNAs achieve the precise coordination of complex biological processes such as neocortical development.
CD59 functions as a signal-transducing molecule for human T cell activation (1991)

The CD59 Ag is a 20-kDa protein that is widely expressed on most leukocytes and RBC, is coupled to the membrane by a phosphatidylinositol-glycan anchoring structure, plays a role in cell interaction between monocytes and T cells, and also functions as an inhibitor of cytolysis by the terminal C components C5b-9. Because this molecule is structurally related to the murine Ly-6 family of Ag, we have investigated whether anti-CD59 mAb might be capable of activating human T lymphocytes in a manner similar to that described for antibodies to the murine Ly-6 Ag. In the presence of the appropriate co-stimulators, mAb to one of the two epitopes on CD59 were capable of inducing both a rise in intracytoplasmic free Ca2+, inositol phosphate production, IL-2 production, and T cell proliferation. Anti-CD59-induced inositol phosphate turnover and IL-2 production were dependent on co-expression of the CD3/TCR complex. CD59-loss mutants of the Jurkat cell line were completely responsive to stimulation by anti-CD3 thereby demonstrating that CD59 does not play a role as a signal transducer downstream from the TCR. Taken together, these results demonstrate that the CD59 Ag can play multiple distinct roles in the regulation of the immune response.
An improved residue number system digital-to-analog converter (1983)

A new technique for Residue Number System (RNS) Digital-to-Binary or Digital-to-Analog conversion based on the Chinese Remainder Theorem allows conversion with only one level of ROM and one level of Adders. The ROM's are small (e.g., 256 x 8) and the Adders use standard binary adders. Compared to previous Chinese Remainder Theorem or Mixed-Radix-Conversion Techniques, the new technique offers conversion times which are independent of the number of Residue Number System moduli and conversion times are usually much faster than competative techniques. The new technique also allows for rounding or truncation to fewer bits and sign-detection by simple modifications to the procedure. These modifications yield particularly simple and fast hardware.
Ranking the Interestingness of Summaries from Data Mining Systems (1999)

We study data mining where the task is description by summarization, the representation language is generalized relations, the evaluation criteria are based on heuristic measures of interestingness, and the method for searching is the Multi-Attribute Generalization algorithm for domain generalization graphs. We present and empirically compare four heuristics for ranking the interestingness of generalized relations (or summaries). The measures are based on common measures of the diversity of a population, statistical variance, the Simpson index, and the Shannon index. All four measures rank less complex summaries (i.e., those with few tuples and/or non-ANY attributes) as most interesting. Highly ranked summaries provide a reasonable starting point for further analysis of discovered knowledge.
Interactive animation of cloth-like objects for virtual reality (2000)

In this chapter, we propose a stable and efficient algorithm for animating cloth-like materials using mass-spring systems. An integration scheme derived from implicit integration allows us to obtain interactive realistic animation of any mass-spring network. We alleviate the need to solve a linear system through the use of a predictor-corrector approach: We first compute a rapid approximation of the implicit integration, then we correct this estimate in a post-step process to preserve momentum. Combined with a post-step process to implement collisions and other constraints, this method provides a simple, stable and tunable model for cloth-like objects suitable for virtual reality. An implementation in a VR environment demonstrates this approach through a series of examples.
Copper/carbon core shell nanoparticles as additive for natural fiber/wood plastic blends (2012)

Copper/carbon core/shell nanoparticles (CCCSNs) recently have been introduced as an industrial material. In this paper, composites based on high density polyethylene (HDPE), bamboo fiber, CCCSNs, and coupling agent (MAPE) were prepared by melt compounding. The influence of CCCSN content on the resulting composites’ mechanical, biological resistance, and thermal properties was investigated. It was found that CCCSNs within the carbon black matrix were processed well with bamboo fiber-plastic blends through mixing and injection molding. The materials enhanced composite strength and modulus-related properties. Composites with CCCSNs and natural fibers reduced heat capacity and thermal diffusivity. Composites with CCCSN materials also enhanced termite and mold performance. Thus, the material can be used as additive for plastics and other polymers to modify strength properties, biological resistance (e.g., mold and stain), and thermal conductivity properties.
Mechanisms of eosinophil cytokine release (2005)

Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.
Autoantibody Induction by DNA-Containing Immune Complexes Requires HMGB1 with the TLR2/MicroRNA-155 Pathway (2013)

Anti-dsDNA Ab is reported to be the central pathogenic autoantibody involved in systemic lupus erythematosus (SLE) pathogenesis. However, the mechanisms involved in anti-dsDNA Ab production remain unclear. Recent evidence indicated that DNA-containing immune complexes (ICs) in circulation (termed "circulating DNA-containing ICs"), which are one of the hallmarks of SLE, might be involved in autoantibody production. In this study, we explored their potential role in anti-dsDNA Ab production and the underlying mechanisms in patients with SLE. We demonstrated that circulating DNA-containing ICs were able to induce anti-dsDNA Ab. Of note, HMGB1 in circulating DNA-containing ICs was crucial for anti-dsDNA Ab induction. The HMGB1 content of circulating DNA-containing ICs also correlated positively with anti-dsDNA Ab production in patients with SLE. Further, we revealed that the TLR2/MyD88/microRNA-155 (miR-155) pathway was pivotal for HMGB1 to confer anti-dsDNA Ab induction, and Ets-1 was a functional target of miR-155 in the induction of anti-dsDNA Ab by circulating DNA-containing ICs. Finally, we validated the expression of miR-155 and Ets-1 and their correlation with anti-dsDNA Ab production in patients with SLE. To our knowledge, this is the first report of the crucial role of HMGB1 in autoantibody production mediated by the TLR2/MyD88/miR-155/Ets-1 pathway. These findings identify a novel mechanism to account for the persistent production of anti-dsDNA Ab in SLE and a clue for developing a novel therapeutic strategy against SLE.
Goldfish spexin: solution structure and novel function as a satiety factor in feeding control (2013)

Spexin (SPX) is a neuropeptide identified recently by bioinformatic approach. At present not much is known about its biological actions, and comparative studies of SPX in nonmammalian species are still lacking. To examine the structure and function of SPX in fish model, SPX was cloned in goldfish and found to be highly comparable with its mammalian counterparts. As revealed by NMR spectroscopies, goldfish SPX is composed of an α-helix from Gln(5) to Gln(14) with a flexible NH2 terminus from Asn(1) to Pro(4), and its molecular surface is largely hydrophobic except for Lys(11) as the only charged residue in the helical region. In goldfish, SPX transcripts were found to be widely expressed in various tissues, and protein expression of SPX was also detected in the brain. In vivo feeding studies revealed that SPX mRNA levels in the telencephalon, optic tectum, and hypothalamus of goldfish brain could be elevated by food intake. However, brain injection of goldfish SPX inhibited both basal and NPY- or orexin-induced feeding behavior and food consumption. Similar treatment also reduced transcript expression of NPY, AgRP, and apelin, with concurrent rises in CCK, CART, POMC, MCH, and CRH mRNA levels in different brain areas examined. The differential effects of SPX treatment on NPY, CCK, and MCH transcript expression could also be noted in vitro in goldfish brain cell culture. Our studies for the first time unveil the solution structure of SPX and its novel function as a satiety factor through differential modulation of central orexigenic and anorexigenic signals.
Needle-Track Metastasis after Transthoracic Needle Biopsy (1998)

Metastasis along the needle track (NTM) after a transthoracic needle biopsy (TNB) is considered a very rare complication. A survey of the membership of the Society of Thoracic Radiology and a review of the English-language literature were conducted to assess the incidence of this complication and its predisposing factors and natural history. A questionnaire was sent to all radiology departments in the United States and Canada that had a senior member of the Society of Thoracic Radiology. The total number of TNB between 1978 and 1993 and occurrences of NTM were elicited. If an NTM was encountered, information on the size of the nodule, proximity to the pleura, histology, size of the biopsy needle, and the interval between biopsy and NTM and outcome of the patient was elicited. The incidence of NTM was estimated using binomial proportions. Results of the literature survey were tabulated to provide similar information. One hundred sixty-five questionnaires were mailed and 75 responses were received. Approximately 68,346 TNB were reported. Five departments reported a total of eight NTM, resulting in an incidence of 0.012%. The average interval between TNB and NTM was 2.6 months. There were no predictable risk factors. The outcome was known in only 11 patients; 4 patients died by the time of reporting (2 after 14 months and 1 each after 6 and 9 months). From the results of this survey, the incidence of NTM after TNB is approximately 0.012%. This small risk is random and unavoidable.
Surgical findings in the treatment of Dupuytren’s disease after initial treatment with clostridial collagenase (Xiaflex) (2013)

We investigated the difficulty of surgical fasciectomy after previous treatment with clostridial collagenase injection. The 35 clinicians who had participated in the initial trials of this injection were contacted via email. Twenty-eight responded, nine of whom reported on 15 patients. Most (seven of nine) felt there was no significant distortion of anatomy and rated the level of technical difficulty as equivalent to a primary Dupuytren's fasciectomy at the observed degree of contracture (nine of 15 cases). One respondent (four of 15 cases) reported significantly more difficulty and grossly distorted anatomy. One surgical complication, a wound dehiscence, was reported.
Combined Chemical and Enzymatic Synthesis of a Disialylated Tetrasaccharide Analogous to M and N Bloodgroup Determinants of Glycophorin a (1988)

Abstract Reaction of 2,3,4,6-tetra-O-acetyl-α-D-galactopyraaosyl bromide (1) with phenyl 2-acetamido-2-deoxy-4,6-O-(4-methoxy-benzylidene)-α-D-galactopyranoside (3) mediated by mercuric salts, followed by removal of the 4-methoxybenzylidene group and O-deacylation afforded phenyl 2-acetamido-2-deoxy-3-O-p-D-galactopyranosyl-α-D-galactopyranoside (6). Compound 6 was used as a substrate for the selective introduction of two neuraminic acid residues with partially purified sialyltrans-ferase preparations. First, disaccharide 6 was treated with CMP-[14c]-NeuAc as donor substrate and CMP-NeuAc: Gal-p(l-3)-GalNac-a(2-3)sialyltransferase from human placenta to afford trisaccharide 7 (yield 85X), sialylated at C-3 of the galactose residue. Treatment of 7 with CMP-[3H]-NeuAc and a micro-somal fraction from regenerating rat liver, containing the CMP-NeuAc: NeuAc-a(2-3)-Gal-p(l-3)GalNAc-α(2-6) sialyltrans-ferase activity, gave the disialylated tetrasaccharide 8 in 10X yield.