gebhart/patrepeval huggingface dataset:
Development of a two-dimensional optical accelerometer using a DVD pick-up head (2006)

This study develops a low-cost, highly sensitive two-dimensional optical accelerometer based on a commercially available DVD optical pick-up head. Vibrations of the structure of interest cause a change in the angle of the seismic mass within the accelerometer. The relative movement between the seismic mass and the base produces a change in the distribution of a focused light spot on the surface of a four-quadrant photodetector. The resulting change in the voltage signals output by the photodetector is then used to calculate the corresponding acceleration of the base. The experimental results indicate that the sensitivities of the accelerometer in the X- and Y-axis directions are 22.9 V/g and 21.3 V/g, respectively.
The impact of palliative irradiation on the management of patients with acquired immune deficiency syndrome. (1987)

We have studied the natural history of the acquired immune deficiency syndrome (AIDS), and the part that irradiation plays in the management of this devastating and fatal disease. The radioresponsiveness of the two most common malignancies associated with AIDS, Kaposi's sarcoma (KS) and malignant lymphoma (ML), has been demonstrated. We have documented satisfactory time-dose relationships for the management of multiple manifestations of KS, including cutaneous and deep subcutaneous extremity involvement, visceral lesions, and AIDS-associated lymphadenopathy. A similar time-dose construct has been documented for ML, involving the brain and both central and peripheral lymph nodes. Irradiation can provide good to excellent palliation with only minimal side effects, and will produce a lesser impact on the hematological and immunological systems than chemotherapy. Therefore, we advocate the liberal employment of palliative radiation therapy in patients with AIDS.
A simulation model for reliability evaluation of space station power systems (1991)

The dependence of reliability and storage characteristics during Sun and eclipse periods is considered. The charging and discharging of energy storage modules is included on a continuous basis. Sample system studies are also presented. The Monte Carlo analysis program for reliability analysis of a hybrid configuration can model the charging and discharging of energy storage devices in a more realistic manner than the approach of C. Singh et al. (1987). The results shown do not indicate any significant effect on computed reliability indices by this more refined modelling of charge/discharge of energy storage.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
The effect of process variations on interfacial and radiation-induced charge in silicon-on-sapphire capacitors (1978)

We have used extended-range MIS <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C(V)</tex> measurement to carry out a preliminary study of the effect of the variation of epitaxial Si growth parameters on interfactial charge in ion implantation doped silicon-on-sapphire (SOS) capacitors. Our results to date show that 1) both the magnitude and the ploarity of the interfacial charge are affected by the Si growth rate; 2) the magnitude charge are affected by prefiring of the substrate in hydrogen; 3) at room temperature, some annealing of the radiation-induced charge takes place in less than 20 h, and virtually complete annealing takes place within one month; 4) the radiation. The implications for the solution of the back-channel leakage problem are discussed.
A protein with multiple heme-binding sites from rabbit serum. (1982)

A 93,000 molecular weight protein (HBP.93) which binds hemin and protoporphyrin IX with high affinity has been isolated from rabbit serum using affinity chromatography on hemin-conjugated agarose. The amino acid composition of this protein is unique in that the proline and histidine contents are remarkably high (16.6 and 9.9 mol %, respectively). A large increase in the absorbance of the Soret region arises from the heme-protein interaction. The spectrophotometric titration showed that the protein can bind 25-35 mol of hemin/mol of protein. The apparent dissociation constant was estimated to be 1-4 X 10(-7) M for hemin at pH 7.4 and approximately 10(-6) M for protoporphyrin IX at pH 9.2. The similarity of the difference spectrum of heme-HBP.93 complex to that of heme-hemopexin complex suggests that a bisimidazol-type coordination of heme iron is involved in the binding. The extremely high capacity of HBP.93 to bind heme is also demonstrated by a large increase in the sedimentation velocity of the protein upon heme binding. The native heme-protein complex migrates faster than the heme-free protein in a polyacrylamide gel at pH 8.8; the increased mobility appears to be due to the charge on the carboxyl groups of the bound heme. Although the use of a hemin-agarose column has failed to reveal a protein of similar size and heme affinity in the sera of a number of other species, including man, the heme-binding properties and high histidine level of the human alpha 2-histidine-rich glycoprotein raise the possibility that the two proteins are related.
Provenance for Visualizations: Reproducibility and Beyond (2007)

The demand for the construction of complex visualizations is growing in many disciplines of science, as users are faced with ever increasing volumes of data to analyze. In this paper, the authors present VisTrails, an open source provenance-management system that provides infrastructure for data exploration and visualization. VisTrails transparently records detailed provenance of exploratory computational tasks and leverages this information beyond just the ability to reproduce and share results. In particular, it uses this information to simplify the process of exploring data through visualization.
Measurement of glycosylated hemoglobin on cellulose acetate membranes by mobile affinity electrophoresis. (1983)

In this method for separating glycosylated from nonglycosylated hemoglobin in blood by electrophoresis on cellulose acetate membranes, we exploit the affinity of low-molecular-mass dextran sulfate for the nonglycosylated fraction, which increases the mobility of the latter relative to that of glycosylated hemoglobin. After the membrane strips are cleared and stained, the two fractions are quantified densitometrically. As evaluated by use with blood from diabetics, results compare well with those by chromatography on short columns and by electrophoresis in commercial agar gel films.
Thermally stable CGC perpendicular recording media with Pt-rich CoPtCr and thin Pt layers (2002)

The thermal stability of coupled granular/continuous (CGC) perpendicular media is supported by fundamental modeling and experimental results, including spin-stand testing. By incorporating the interlayer exchange coupling into the model, the simulation result suggests that the CGC structure is capable of achieving the energy barrier of K/sub u/V/k/sub B/T required for 1 Tbit/in/sup 2/ recording density. To demonstrate the CGC approach, we investigate a new class of CGC perpendicular media consisting of a Pt-rich CoPtCr layer with poor Co-Cr phase segregation and a thin Pt layer. The addition of these layers improves the nucleation field of the CoCr/sub 18/Pt/sub 12/ medium from +420 to -600 Oe and the thermal decay of the output is reduced from 2.23% to 0.10% per decade. Unity squareness was obtained by using a thin Pt capping layer and resulted in a small decay rate of 0.21% per decade. The new CGC media showed no degradation of SNR compared to the base granular medium. Similar to CGC media utilizing a multilayer capping structure, the CGC medium with a Pt-rich CoPtCr or Pt capping structure improved the thermal stability without compromising SNR. The simplicity of these new CGC structures also greatly simplifies the deposition process.
Preparation of Nitrides by Active Nitrogen: II . (1977)

A general method for the preparation of nitrides is described by which active nitrogen, excited in a microwave cavity, is subsequently reacted with vapors formed in situ by passing iodine vapors over heated silicon powder. The temperature dependence of the deposition of on polished Si wafers was measured and compared with calculated thermodynamic data of similar reactions with nonactive nitrogen. The kinetic measurements were related to the special flow characteristics of the system. The over‐all reaction
A first-in-human phase I dose-escalation study of MK-1496, first-in-class orally available novel PLK1 inhibitor, in patients with advanced solid tumors. (2011)

3012 Background: Polo-like kinase 1 (PLK1) is a serine/threonine kinase involved in cell cycle control, especially has key roles in multiple steps of mitosis progression. Overexpression of PLK1 is frequently observed in a range of human tumors, suggesting PLK1 function is important for proliferation of cancer cells. MK-1496 is an orally available highly potent and selective inhibitor of PLK1 with demonstrated anti-proliferative activity in vitro and in vivo. Methods: Sequential cohorts of 3 to 6 patients (pts) with progressive advanced or metastatic solid tumors received an MK-1496 dosing regimen of days 1 and 3 of each treatment wk for 3 wks followed by 1 wk rest period, following a toxicity guided dose escalation design. A total of 17 pts were treated at doses from 20 to 120 mg. Results: Reversible hematotoxicity was the main side effect constituting DLTs observed at 100 mg and 120 mg. The most frequent G3/4 adverse events were leukopenia (35%), neutropenia (35%), thrombocytopenia (29%), febrile neutropenia (18%) and anemia (18%). The MTD was determined as 80 mg. There was no evidence of cumulative toxicity. The PK profile was evaluated in 17 pts and demonstrated linearity in the dose range, a long t1/2 of around 25-47 hrs. Neutropenia caused by MK-1496 is a mechanism-based effect of PLK1 inhibition and can be used as a PD marker due to a trend of correlation with PK parameters. Two confirmed PRs were observed in pts with parotid gland carcinoma at 80 mg and small cell lung cancer at 120 mg. Conclusions: Preliminary results from this first-in-human trial confirm the favorable PK and safety profiles of the potentially first-in-class PLK1 inhibitor, MK-1496. Encouraging antitumor efficacy has been observed supporting PLK1 as a therapeutic target and further clinical development of this compound.
An image-rejection down-converter for low-IF receivers (2005)

Implemented in 4.1 mm/sup 2/ in 130-nm CMOS, a dual-conversion image-rejection down-converter applied to the wireless code-division multiple-access (WCDMA) standard draws 13 mA from a single 1.8-V power supply. Using an IF of 2.5 MHz, the WCDMA image-rejection band is widened from 0.58-4.42 MHz to 0.48-5.2 MHz-a bandwidth ratio of 10.8-to accommodate process, voltage, and temperature variations in high-volume production. Ten samples are measured and fully characterized: average image-rejection ratio (IRR) is 46.6 dBc, gain is 12 dB, and noise figure is 10.8 dB. Typical IRR is 44.8, 46.5, and 47.5 dBc at -20/spl deg/C, 25/spl deg/C, and 80/spl deg/C, respectively.
Quantitative Proteomic Profiling of Prostate Cancer Reveals a Role for miR-128 in Prostate Cancer (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of biomarkers of cancer invasion and disease aggressiveness. Although alterations in gene expression have been extensively quantified during neoplastic progression, complementary analyses of proteomic changes have been limited. Here we interrogate the proteomic alterations in a cohort of 15 prostate-derived tissues that included five each from adjacent benign prostate, clinically localized prostate cancer, and metastatic disease from distant sites. The experimental strategy couples isobaric tags for relative and absolute quantitation with multidimensional liquid phase peptide fractionation followed by tandem mass spectrometry. Over 1000 proteins were quantified across the specimens and delineated into clinically localized and metastatic prostate cancer-specific signatures. Included in these class-specific profiles were both proteins that were known to be dysregulated during prostate cancer progression and new ones defined by this study. Enrichment analysis of the prostate cancer-specific proteomic signature, to gain insight into the functional consequences of these alterations, revealed involvement of miR-128-a/b regulation during prostate cancer progression. This finding was validated using real time PCR analysis for microRNA transcript levels in an independent set of 15 clinical specimens. miR-128 levels were elevated in benign prostate epithelial cell lines compared with invasive prostate cancer cells. Knockdown of miR-128 induced invasion in benign prostate epithelial cells, whereas its overexpression attenuated invasion in prostate cancer cells. Taken together, our profiles of the proteomic alterations of prostate cancer progression revealed miR-128 as a potentially important negative regulator of prostate cancer cell invasion.
Comparison of Enzymatic and Non-Enzymatic Means of Dissociating Adherent Monolayers of Mesenchymal Stem Cells (2009)

The dissociation of adherent mesenchymal stem cell (MSC) monolayers with trypsin and enzyme-free dissociation buffer was compared. A significantly lower proportion of viable cells were obtained with enzyme-free dissociation buffers compared to trypsin. Subsequently, the dissociated cells were re-seeded on new cell culture dishes and were subjected to the MTT assay 24 h later. The proportion of viable cells that reattached was significantly lower for cells obtained by dissociation with enzyme-free dissociation buffer compared to trypsin. Frozen-thawed MSC displayed a similar trend, yielding consistently higher cell viability and reattachment rates when dissociated with trypsin compared to enzyme-free dissociation buffer. It was also demonstrated that exposure of trypsin-dissociated MSC to enzyme-free dissociation buffer for 1 h had no significant detrimental effect on cell viability.
New concepts in the production of specialty steels in bars and coils (1997)

Danieli has developped a complete integrated metallurgical process for the newer mini-mills. It assures prime quality of the products, an attractive reduction of the production cost through energy and storage savings, an improved satisfaction of the customer with short delivery times. It consists in direct rolling of blooms or billets coming from the continuous caster ; it is named the Black Box concept. This implies an entirely new approach of the mill design and operation. Three sites are now producing using this concept and two are scheduled to be commissioned in 1998.
Pneumocystis carinii Pneumonia Among Patients Without AIDS at a Cancer Hospital (1992)

Despite the availability of effective prophylaxis, P carinii pneumonia continues to occur among patients with neoplastic disease. In addition to patients with certain hematologic neoplasms, those with primary or metastatic brain neoplasm who receive corticosteroids are at risk for the development of P carinii pneumonia and should receive P carinii pneumonia prophylaxis.
Stand-alone Cervical Cages Versus Anterior Cervical Plate in 2-Level Cervical Anterior Interbody Fusion Patients (2012)

Study Design: Retrospective study. Objectives: To compare the efficacy of 2-level anterior cervical discectomy and fusion with cage alone (ACDF-CA) and with cage and plate construct (ACDF-CPC) with regard to clinical outcome and radiologic changes. Summary of Background Data: The use of stand-alone cervical interbody cages in ACDF has become popular, but high subsidence rates have been reported in the literature. Methods: A total of 54 consecutive patients who underwent 2-level ACDF-CA or ACDF-CPC after suffering from cervical radiculopathy were divided into 2 groups: group A (n=28) underwent ACDF-CA, group B (n=26) underwent ACDF-CPC. Fusion rate, global and segmental kyphosis, disk height, and subsidence rate were assessed by radiolographs. Clinical outcomes were assessed using Robinson’s criteria. Results: Solid fusion was achieved in 96.43% (27/28) in group A and in 96.15% (25/26) in group B. Fusion segmental kyphosis of >5 degrees occurred in 14.29% (4/28) of group A and in 7.69% (2/26) of group B; however, there was no statistical difference between the 2 groups (P>0.05). Subsidence occurred in 35.71% (10/28) of group A as compared with 11.54% (3/26) of group B (P<0.05). Clinical outcomes were similar in the 2 treatment groups. Conclusions: The use of cage and plate construct in 2-level ACDF results in a shorter fusion duration and a lower subsidence rate than that of cage alone; however, there is no significant difference in the postoperative global and segmental alignment and clinical outcomes between groups.
mazF, a novel counter-selectable marker for unmarked chromosomal manipulation in Bacillus subtilis (2006)

Here, we present a novel method for the directed genetic manipulation of the Bacillus subtilis chromosome free of any selection marker. Our new approach employed the Escherichia coli toxin gene mazF as a counter-selectable marker. The mazF gene was placed under the control of an isopropyl-beta-D-thiogalactopyranoside (IPTG)-inducible expression system and associated with a spectomycin-resistance gene to form the MazF cassette, which was flanked by two directly-repeated (DR) sequences. A double-crossover event between the linearized delivery vector and the chromosome integrated the MazF cassette into a target locus and yielded an IPTG-sensitive strain with spectomycin-resistance, in which the wild-type chromosome copy had been replaced by the modified copy at the targeted locus. Another single-crossover event between the two DR sequences led to the excision of the MazF cassette and generated a strain with IPTG resistance, thereby realizing the desired alteration to the chromosome without introducing any unwanted selection markers. We used this method repeatedly and successfully to inactivate a specific gene, to introduce a gene of interest and to realize the in-frame deletion of a target gene in the same strain. As there is no prerequisite strain for this method, it will be a powerful and universal tool.
Hormone Therapy and Risk of Myocardial Infarction (2009)

Evaluation of: Lokkegaard E, Andreasen AH, Jacobsen RK, Nielsen LH, Agger C, Lidegaard O: Hormone therapy and risk of myocardial infarction: a national register study. Eur. Heart J. 29(21), 2660-2668 (2008). In a national register study of healthy women aged 51-69 years in Denmark followed between 1995 and 2001, 4947 incident myocardial infarction cases were identified. Overall, there was no increased risk of myocardial infarction in current hormone therapy users. However, an increased relative risk was observed in younger women (aged 51-54 years). Overall, the highest risk of myocardial infarction was found with continuous hormone therapy. There was no increased risk found with unopposed estrogen, cyclical combined therapy or tibolone. A lower risk was found with dermal route. However, no associations were found with progestogen type or estrogen dose.
Frequency Domain Modeling of Inductive Position Sensor with Finite Element Tools (2014)

The paper presents here an inductive position sensor which is based on a horizontally moveable/sliding type of thin rectangular or rhombus-shaped copper (activator element) plate and a row of planar coils, printed directly on the PCB. The frequency domain model of the presented inductive sensor has been developed using the Comsol multiphysics tool to estimate the change in inductance values of planar coils due to eddy current effects in the copper activator element at different horizontal positions. The proposed inductive sensor has been already implemented in the automatic gear shifter modules of leading German cars.
Cardiac valve calcification in haemodialysis patients: role of calcium-phosphate metabolism (1998)

Our study confirmed an increased prevalence of VC in HD patients and selected age and calcium phosphate product as the most predictive parameters. These findings support careful monitoring of calcium metabolism beginning at the early stages of end-stage renal failure to reduce the risk of heart disease.
Ion-implanted base SiGe PNP self-aligned SEEW transistors (2002)

The feasibility of ion-implanting an intrinsic base into an undoped strained SiGe-layer has been demonstrated by fabricating self-aligned selective epitaxy emitter window (SEEW) PNP transistors with ideal Gummel characteristics. Self-aligned SiGe base PNP transistors have been achieved by ion-implanting and annealing arsenic into undoped, stable SiGe layers. Ideal I-V characteristics were achieved with both Si and SiGe base devices, indicating that the implant damage was successfully annealed out. The results demonstrate the feasibility of fabricating SiGe base structures with a conventional ion-implanted approach.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Mobilitatea structurilor industriale, element determinant al capacitatii de adaptare (2004)

Adaptability has the main role in providing economic growth and resistance to external shocks. In this respect, an important factpr is industrial structural mobility and its rapidity of change. Based on an accomplished analysis, some objectives have been established in order to increase the adaptation capability of the companies.
Development of a Sustained-Release Voriconazole-Containing Thermogel for Subconjunctival Injection in Horses (2017)

Voriconazole-containing thermogels have potential application in treatment of keratomycosis. Further research is required to evaluate their performance in vivo.
The AST All-digital Tuner Chip Set (2005)

This paper describes a pair of chips developed at Applied Signal Technology (AST) to be used for down converting and isolating narrow band signals from a wideband source. The chips will accept 12 bit data sampled at rates up to 35 MHz and will isolate signals with bandwidths up to 70 kHz wide. The output sample rate can be varied between 70 kHz (decimate by 512) and 4.27 kHz (decimate by 8 1 92).
The Application of VB Matlab and AutoCAD in IC Engine Optimization Design (2014)

Estimating the advantages and disadvantages of Matlab/Simulink, Visual Basic (VB) and AutoCAD software, the model of the working process of internal combustion (IC) engine was built based on Matlab/Simulink, and the drawing programs for engine structure were written with the parametric design language AutoLISP. A user-friendly VB interface of inputting parameter was established, realizing VB coupled with AutoCAD and Matlab/Simulink software. Calling the AutoLISP drawing program nested in the AutoCAD and Matlab/Simulink software via VB, integration of the simulation and analysis of the engine and the CAD drawing of its body can be achieved. Its more efficient to analyze the performance and optimize the structure parameters of engines.
Three-beam magneto-optical disk drive with overwrite function (1992)

We developed a 5 inch form factor magneto-optical disk drive with overwrite and real-time verification functions. A 2.1 MB/s data transfer rate for both reading and writing and an average seek time of less than 35 ms have been achieved. The 3-beams drive uses 130 mm ISO-standard magneto-optical disks. This high-performance magneto-optical disk drive provides high-speed operation and low-cost storage and is suitable for high-end systems such as optical libraries and image-data processing systems which require a high transfer rate and huge data capacity.