gebhart/patrepeval huggingface dataset:
Robust tie-point registration of disparate imaging sensors by matching optical flow (2002)

Many imaging systems consist of a combination of distinct electro-optic sensors that are constrained to view the same scene through a common aperture or from a common platform. Oftentimes, a spatial registration of one sensor's image is required to conform to the slightly disparate imaging geometry of a different sensor on the same platform. This is generally achieved through a judicious selection of image tie-points and geometric transformation model. This paper outlines a procedure to improve any such registration technique by leveraging the temporal motion within a pair of video sequences and requiring an additional constraint of minimizing the disparity in optical flow between registered video sequences.
The reaction of Tetrazole with Phosphoramidites as a Model for the Nucleotide Coupling Step (1988)

Abstract The mechanism of the tetrazole-activated coupling step in the synthesis of oligonucleotides via phosphorami-dites is studied with the help of model reactions.
Use of the subcutaneous route for the administration of narcotics in patients with cancer pain (1988)

From February 1985 until January 1987, 108 consecutive patients with pain due to advanced cancer requiring parenteral narcotics were treated with a subcutaneous infusion of morphine (62 patients) or hydromorphone (46 patients). Mean maximal daily dose of morphine and hydromorphone was 305 mg (range, 80-3000 mg) and 310 mg (range, 40-4024 mg), respectively. The infusion was maintained for a mean of 31 +/- 16 days (range, 2-156). Seventy patients were treated with a portable pump. Of these patients, 33 (45%) were discharge home for a mean of 29 +/- 20 days. Eighty-six of one hundred eight (86/108, 80%) patients experienced adequate pain control (less than two extra doses of analgesics per day). The duration of the site of the infusion was 7 days (range, 2-31). The mean daily increase in those was 2.4 +/- 1.6% of the initial dose (only 15% of patients needed an increase more than or equal to 5% per day). Systemic toxicity consisted of respiratory depression in two patients, severe sedation in six, and confusion in three; all patients improved upon reduction of the daily dose of narcotics. Local toxicity consisted in infection in two patients, bleeding in one, and chemical irritation in six. Cost analysis shows that subcutaneous infusion reduced costs by either allowing home discharges, or replacing intravenous infusion. The authors conclude that this method is safe and effective in patients admitted and at home, and should be considered the first choice when parenteral analgesia is required.
Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment (2012)

Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic antimicrobial responses in vitro. Vitamin D supplementation elevates circulating calcidiol concentrations, and thus has a potential role in the prevention and treatment of infection. The immunomodulatory effects of administering vitamin D to humans with an infectious disease have not previously been reported. To characterize these effects, we conducted a detailed longitudinal study of circulating and antigen-stimulated immune responses in ninety-five patients receiving antimicrobial therapy for pulmonary tuberculosis who were randomized to receive adjunctive high-dose vitamin D or placebo in a clinical trial, and who fulfilled criteria for per-protocol analysis. Vitamin D supplementation accelerated sputum smear conversion and enhanced treatment-induced resolution of lymphopaenia, monocytosis, hypercytokinaemia, and hyperchemokinaemia. Administration of vitamin D also suppressed antigen-stimulated proinflammatory cytokine responses, but attenuated the suppressive effect of antimicrobial therapy on antigen-stimulated secretion of IL-4, CC chemokine ligand 5, and IFN-α. We demonstrate a previously unappreciated role for vitamin D supplementation in accelerating resolution of inflammatory responses during tuberculosis treatment. Our findings suggest a potential role for adjunctive vitamin D supplementation in the treatment of pulmonary infections to accelerate resolution of inflammatory responses associated with increased risk of mortality.
FMnet: Iris Segmentation and Recognition by Using Fully and Multi-Scale CNN for Biometric Security (2019)

In Deep Learning, recent works show that neural networks have a high potential in the field of biometric security. The advantage of using this type of architecture, in addition to being robust, is that the network learns the characteristic vectors by creating intelligent filters in an automatic way, grace to the layers of convolution. In this paper, we propose an algorithm “FMnet” for iris recognition by using Fully Convolutional Network (FCN) and Multi-scale Convolutional Neural Network (MCNN). By taking into considerations the property of Convolutional Neural Networks to learn and work at different resolutions, our proposed iris recognition method overcomes the existing issues in the classical methods which only use handcrafted features extraction, by performing features extraction and classification together. Our proposed algorithm shows better classification results as compared to the other state-of-the-art iris recognition approaches.
Bitumen Cracking in Supercritical Water Upflow (2013)

Bitumen was cracked in a high-pressurized water upflow at 440 °C and 10, 25, and 30 MPa using continuous stirred tank reactor. At 30 MPa, which was the optimal dispersion condition, the highest liquid yield, lowest coke, highest conversion, and heaviest liquid products were obtained. Even at optimal conditions, all the asphaltene (AS) could not be entrained with the supercritical water (SCW) upflow; thus, the product oil contained <0.5% of AS. This means that bitumen cracking in the SCW upflow was a combined process of thermal upgrading and deasphalting.
Spontaneous exfoliation and tailoring of MoS<sub>2</sub>in mixed solvents (2014)

Spontaneous exfoliation of MoS2 is achieved in H2O2-NMP mixed solvents with a yield of over 60 wt%, operated under mild conditions. H2O2-prompted sheet-tailoring effect induces a size evolution of MoS2 nanosheets from micro-scale to nano-scale. Furthermore, the concurrent dissolution also affords an approach to introduce structural defects in the nanosheets.
[Stability of liensinine injection]. (1993)

The stability of liensinine injection was studied by accelarating test with classical isothermal method. Results of the study showed that the decomposition of the injection was found to be a first-order reaction. The activation energy was 75030 J.mol-1. The shelf life at 10 degrees C and 25 degrees C was predicted to be about 15 months and 3 months respectively. This experiment provides a reference for the storage of the injection.
A phase I clinical trial of bavituximab and paclitaxel in patients with HER2 negative metastatic breast cancer (2015)

Bavituximab is a chimeric monoclonal antibody that targets phosphatidylserine (PS). PS is externalized on cells in the tumor microenvironment when exposed to hypoxia and/or other physiological stressors. On attaching to PS, bavituximab is thought to promote antitumor immunity through its effects on PS receptors in monocytes, and myeloid-derived suppressor cells, as well as trigger antitumor effects by inducing an antibody-dependent cellular cytotoxicity on tumor-associated endothelial cells. We conducted a phase I clinical trial of bavituximab in combination with paclitaxel in patients with HER2-negative metastatic breast cancer. Patients were treated with weekly paclitaxel (80 mg/m(2) for 3/4 weeks) and weekly bavituximab (3 mg/kg for 4/4 weeks). Correlative studies included the measurement of circulating microparticles, endothelial cells, and apoptotic tumor cells by flow cytometry. Fourteen patients with metastatic breast cancer were enrolled; all were evaluable for toxicity and 13 were evaluable for response. Treatment resulted in an overall response rate (RR) of 85% with a median progression-free survival (PFS) of 7.3 months. Bone pain, fatigue, headache, and neutropenia were the most common adverse effects. Infusion-related reactions were the most common adverse event related to bavituximab therapy. Correlative studies showed an increase in the PS-expressing apoptotic circulating tumor cells in response to bavituximab, but not with paclitaxel. No changes in the number of circulating endothelial cells or apoptotic endothelial cells were observed with therapy. Platelet and monocyte-derived microparticles decreased after initiation of bavituximab. Bavituximab in combination with paclitaxel is well tolerated for treatment of patients with metastatic breast cancer with promising results observed in terms of clinical RRs and PFS. The toxicity profile of bavituximab is notable for manageable infusion-related reactions with no evidence for increased thrombogenicity. Recent preclinical data suggest that bavituximab can also promote antitumor immune activity that should be explored in future clinical trials.
Identification of a 68-kilodalton protective protein antigen from Bordetella bronchiseptica (1985)

A 68-kilodalton (kd) outer membrane protein antigen of Bordetella bronchiseptica has been identified by using monoclonal antibodies that recognized two nonoverlapping determinants. Antibody BB05 also reacted with homologous proteins from Bordetella pertussis and Bordetella parapertussis but not with another 12 organisms from various bacterial genera. Passive injection of BB05 antibody protected mice from aerosol infection with B. bronchiseptica as shown by reduced mortality and reduced pathology of turbinate bones. The 68-kd B. bronchiseptica antigen was purified by BB05-based affinity chromatography and evaluated for its potency to immunize mice actively against either intraperitoneal or aerosol challenge with B. bronchiseptica. Immunization with the 68-kd antigen in incomplete Freund adjuvant significantly reduced the levels of mortality in intraperitoneally challenged mice. In the aerosol infection model, injection of the 68-kd antigen with complete or incomplete Freund adjuvant or saponin reduced the bacterial counts in the lungs of infected mice. These results suggest that the 68-kd protein may represent a potential "protective" antigen of B. bronchiseptica.
Theory of elastic and piezoelectric effects in two-dimensional hexagonal boron nitride (2009)

Starting from an empirical force constant model of valence interactions and calculating by Ewald's method the ion-ion force constants, we derive the dynamical matrix for a monolayer crystal of hexagonal boron nitride (h-BN). The phonon dispersion relations are calculated. The interplay between valence and Coulomb forces is discussed. It is shown by analytical methods that the longitudinal and the transverse optical (LO and TO) phonon branches for in-plane motion are degenerate at the $\ensuremath{\Gamma}$ point of the Brillouin zone. Away from $\ensuremath{\Gamma}$, the LO branch exhibits pronounced overbending. It is found that the nonanalytic Coulomb contribution to the dynamical matrix causes a linear increase of the LO branch with increasing wave vector starting at $\ensuremath{\Gamma}$. This effect is general for two-dimensional (2D) ionic crystals. Performing a long-wavelength expansion of the dynamical matrix, we use Born's perturbation method to calculate the elastic constants (tension coefficients). Since the crystal is noncentrosymmetric, internal displacements due to relative shifts between the two sublattices (B and N) contribute to the elastic constants. These internal displacements are responsible for piezoelectric and dielectric phenomena. The piezoelectric stress constant and the dielectric susceptibility of 2D h-BN are calculated.
Complete Genome Sequence of Bacillus amyloliquefaciens TA208, a Strain for Industrial Production of Guanosine and Ribavirin (2011)

Here, we report the complete genome sequence of Bacillus amyloliquefaciens TA208, a strain for industrial production of guanosine and synthesis of ribavirin by assimilation of formamide. Comparison of its genome sequence with those of strains DSM7 and FZB42 revealed horizontal gene transfer represented by unique prophages and restriction-modification systems and indicated significant accumulation of guanosine.
Long-Term Visual Localization Using Semantically Segmented Images (2018)

Robust cross-seasonal localization is one of the major challenges in long-term visual navigation of autonomous vehicles. In this paper, we exploit recent advances in semantic segmentation of images, i.e., where each pixel is assigned a label related to the type of object it represents, to attack the problem of long-term visual localization. We show that semantically labeled 3D point maps of the environment, together with semantically segmented images, can be efficiently used for vehicle localization without the need for detailed feature descriptors (SIFT, SURF, etc.), Thus, instead of depending on hand-crafted feature descriptors, we rely on the training of an image segmenter. The resulting map takes up much less storage space compared to a traditional descriptor based map. A particle filter based semantic localization solution is compared to one based on SIFT-features, and even with large seasonal variations over the year we perform on par with the larger and more descriptive SIFT-features, and are able to localize with an error below 1 m most of the time.
"... That the biological phenomenon we call Aging is worthy of scientific pursuit" (1990)

Journal Article “… That the biological phenomenon we call Aging is worthy of scientific pursuit” Get access Nathan W. Shock Nathan W. Shock Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Gerontology, Volume 45, Issue 1, January 1990, Pages B1–B2, https://doi.org/10.1093/geronj/45.1.B1 Published: 01 January 1990
Primary and secondary prevention of arterial thromboembolism (1994)

Aspirin in doses of approximately 300 mg/day may be recommended for the primary prevention of myocardial infarction in males and probably also in females, but only in those individuals with a moderate to high risk of cardiovascular disease. In patients with stable angina, aspirin decreases the risk for a first myocardial infarction. Aspirin or ticlopidine should be given to patients with unstable angina, in conjunction with heparin in the most severe cases. Long-term oral anticoagulant treatment after myocardial infarction in low risk patients has a limited effect on mortality but reduces the incidence of non-fatal recurrent myocardial infarction and stroke. Daily aspirin is more convenient and simple, and is at least as effective, but associated with a lower risk of bleeding. The concurrent use of aspirin and low intensity anticoagulation in the secondary prevention of myocardial infarction has, however, not been investigated. Various antiplatelet agents, including aspirin (alone or combined with dipyridamole) and ticlopidine, have, in contrast to oral anticoagulants, proved useful in the prevention of early thrombosis in aorto-coronary grafts, provided treatment begins at the latest 6 h after surgery. The usefulness of antiplatelet drugs has been well established in the prevention of immediate reocclusion following coronary angioplasty, but so far no drugs can prevent late restenosis. In patients with a synthetic cardiac valve prosthesis, lifelong treatment with coumarins is still indispensable, but their antithrombotic effect can be reinforced by dipyridamole or aspirin which also allows to reduce the intensity of anticoagulation. In uncomplicated bioprosthetic valve replacement, low intensity anticoagulation during the first 3 months suffices. Diuretics probably provide the best primary protection against cerebrovascular accidents in moderate hypertensives, although medium doses of aspirin may be considered in elderly people at high risk of such accidents. Aspirin (alone or combined with dipyridamole) and ticlopidine may be recommended for the secondary prevention of cerebral ischaemic accidents. Aspirin and ticlopidine, but not oral anticoagulants, reinforce the treatment of obliterative arterial disease in the lower limbs.
Efficient selection of influential nodes for viral marketing in social networks (2017)

There has been an exponential growth in social networking and online shopping with the internet revolution in the recent past. Viral marketing, exploiting social networks to promote various products, has proved successful in influencing the public compared to other media. One well known task in this area is to choose the best nodes that maximize the overall influence propagated in the social network. t-Influence Maximization problem has been addressed in this paper which can be defined as maximizing the overall influence in a social network by selecting seeds for the given t products with their seed requirements. Constraints are set on number of products to be recommended for any single user (to avoid spamming) and total number of seeds to be selected for a particular product (budget constraint). The technique we have used, a greedy algorithm to the aforementioned t-influence maximization problem. It not only allocates seeds with maximum total influence, but also ensures that any one product doesn't dictate the overall influence and a fair selection is done. An efficient algorithm is designed for calculating the approximate influence of the selected nodes which is important in practical situations. Effectiveness and scalability of the algorithm is analyzed and verified using simulations on real-life facebook data.
The a‐sulfonation of pelargonic, stearic, and substituted stearic acids (1960)

Abstract Direct sulfonation of higher fatty acids with sulfur trioxide or chlorosulfonic acid, without use of solvent, is possible, but the product must then be isolated as the sodium salt. Use of a chlorinated solvent permits isolation of the α‐sulfo acid. Sulfonation with dioxane sulfur trioxide in place of sulfur trioxide gave a nearly colorless α‐sulfostearic acid. Substituted stearic acids derived from oleic or elaidic acids (phenyl‐, 9,10‐dichloro‐, and 9,10‐dihydroxystearic acids) were α‐sulfonated with dioxane sulfur trioxide. Solubility, detergent, and surface‐active properties were examined and related to structure. The surface‐active properties of sodium α‐sulfopelargonic acid are not very evident, but the octyl ester, with a much lower critical micelle concentration (0.08% compared to 1.00%), was found to be a very efficient wetting agent.
Kinetic studies on the hydroxylation of <i>p</i>-coumaric acid to caffeic acid by spinach-beet phenolase (1975)

1. A spectrophotometric assay is described that enables the hydroxylation of p-coumaric acid to caffeic acid, catalysed by spinach-beet phenolase, to be followed continuously. 2. Initial-velocity and inhibitor studies indicate that the order of substrate addition is oxygen, p-coumaric acid and electron donor, with an irreversible step separating the binding of each substrate. 3. Caffeic acid is most likely to act as electron donor at the active site; other electron donors, such as ascorbic acid, NADH and dimethyltetrahydropteridine, function mainly to recycle cofactor amounts of caffeic acid. 4. A reaction scheme, consistent with these data, is proposed.
Rational development of a protective P. vivax vaccine evaluated with transgenic rodent parasite challenge models (2017)

Development of a protective and broadly-acting vaccine against the most widely distributed human malaria parasite, Plasmodium vivax, will be a major step towards malaria elimination. However, a P. vivax vaccine has remained elusive by the scarcity of pre-clinical models to test protective efficacy and support further clinical trials. In this study, we report the development of a highly protective CSP-based P. vivax vaccine, a virus-like particle (VLP) known as Rv21, able to provide 100% sterile protection against a stringent sporozoite challenge in rodent models to malaria, where IgG2a antibodies were associated with protection in absence of detectable PvCSP-specific T cell responses. Additionally, we generated two novel transgenic rodent P. berghei parasite lines, where the P. berghei csp gene coding sequence has been replaced with either full-length P. vivax VK210 or the allelic VK247 csp that additionally express GFP-Luciferase. Efficacy of Rv21 surpassed viral-vectored vaccination using ChAd63 and MVA. We show for the first time that a chimeric VK210/247 antigen can elicit high level cross-protection against parasites expressing either CSP allele, which provide accessible and affordable models suitable to support the development of P. vivax vaccines candidates. Rv21 is progressing to GMP production and has entered a path towards clinical evaluation.
Co-Validation: Using Model Disagreement on Unlabeled Data to Validate Classification Algorithms (2004)

In the context of binary classification, we define disagreement as a mea-sure of how often two independently-trained models differ in their clas-sification of unlabeled data. We explore the use of disagreement for error estimation and model selection. We call the procedure co-validation, since the two models effectively (in)validate one another by comparing results on unlabeled data, which we assume is relatively cheap and plen-tiful compared to labeled data. We show that per-instance disagreement is an unbiased estimate of the variance of error for that instance. We also show that disagreement provides a lower bound on the prediction (gen-eralization) error, and a tight upper bound on the “variance of prediction error”, or the variance of the average error across instances, where vari-ance is measured across training sets. We present experimental results on several data sets exploring co-validation for error estimation and model selection. The procedure is especially effective in active learning set-tings, where training sets are not drawn at random and cross validation overestimates error. 1
Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG‐M and the tumor‐associated antigen HTgp‐175 (1998)

Progression to malignancy of transformed cells involves complex genetic alterations and aberrant gene expression patterns. While aberrant gene expression is often caused by alterations in individual genes, the contribution of the tumoral environment to the triggering of this gene expression is less well established. The stable but heterogeneous expression in cultured EL4/13 cells of a novel tumor-associated antigen, designated as HTgp-175, was chosen for the investigation of gene expression during tumor formation. Homogeneously HTgp-175-negative EL4/13 cells, isolated by cell sorting or obtained by subcloning, acquired HTgp-175 expression as a result of tumor formation. The tumorigenicity of HTgp-175-negative vs. HTgp-175-positive EL4 variants was identical, indicating that induction but not selection accounted for the phenotypic switch from HTgp-175-negative to HTgp-175-positive. Although mutagenesis experiments showed that the protein was not essential for tumor establishment, tumor-derived cells showed increased malignancy, linking HTgp-175 expression with genetic changes accompanying tumor progression. This novel gene expression was not an isolated event, since it was accompanied by ectopic expression of the large chondroitin sulfate proteoglycan PG-M and of normal differentiation antigens. We conclude that signals derived from the tumoral microenvironment contribute significantly to the aberrant gene expression pattern of malignant cells, apparently by fortuitous activation of differentiation processes and cause expression of novel differentiation antigens as well as of inappropriate tumor-associated and ectopic antigens. Int. J. Cancer 78:503–510, 1998.© 1998 Wiley-Liss, Inc.