gebhart/patrepeval huggingface dataset:
Effects of consumption of choline and lecithin on neurological and cardiovascular systems. (1982)

This report concerns possible adverse health effects and benefits that might result from consumption of large amounts of choline, lecithin, or phosphatidylcholine. Indications from preliminary investigations that administration of choline or lecithin might alleviate some neurological disturbances, prevent hypercholesteremia and atherosclerosis, and restore memory and cognition have resulted in much research and public interest. Symptoms of tardive dyskinesia and Alzheimer's disease have been ameliorated in some patients and varied responses have been observed in the treatment of Gilles de la Tourette's disease, Friedreich's ataxia, levodopa-induced dyskinesia, mania, Huntington's disease, and myasthenic syndrome. Further clinical trials, especially in conjunction with cholinergic drugs, are considered worthwhile but will require sufficient amounts of pure phosphatidylcholine. The public has access to large amounts of commercial lecithin. Because high intakes of lecithin or choline produce acute gastrointestinal distress, sweating, salivation, and anorexia, it is improbable that individuals will incur lasting health hazards from self-administration of either compound. Development of depression or supersensitivity of dopamine receptors and disturbance of the cholinergic-dopaminergic-serotinergic balance is a concern with prolonged, repeated intakes of large amounts of lecithin.
The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children (2007)

The C-Myb transcription factor is essential for hematopoiesis, including in the T-cell lineage. The C-Myb locus is a common site of retroviral insertional mutagenesis, however no recurrent genomic involvement has been reported in human malignancies. Here, we identified 2 types of genomic alterations involving the C-MYB locus at 6q23 in human T-cell acute leukemia (T-ALL). First, we found a reciprocal translocation, t(6;7)(q23;q34), that juxtaposed the TCRB and C-MYB loci (n = 6 cases). Second, a genome-wide copy-number analysis by array-based comparative genomic hybridization (array-CGH) identified short somatic duplications that include C-MYB (MYB(dup), n = 13 cases of 84 T-ALL, 15%). Expression analysis, including allele-specific approaches, showed stronger C-MYB expression in the MYB-rearranged cases compared with other T-ALLs, and a dramatically skewed C-MYB allele expression in the TCRB-MYB cases, which suggests that a translocation-driven deregulated expression may overcome a cellular attempt to down-regulate C-MYB. Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature. By contrast, the MYB(dup) alteration was associated with the previously defined T-ALL subtypes.
<title>Recent progress on silica-based optical switches and free-space optical switches</title> (1996)

Space-division optical switches will be indispensable for future fiber-optic communication systems such as fiber-optic subscriber-line concentrators, photonic inter-module connectors, and protection switches. This paper reports recent progress on both silica-based thermo-optic optical switches with drive electronics. Two types of free-space switch modules are also reviewed; analog free-space switching modules which use liquid crystal beam shifters and digital free-space switching modules which incorporate semiconductor photonic switch array devices.
Fruit softening in banana: correlation among stress‐relaxation parameters, cell wall components and starch during ripening (1994)

Bananas, Musa (AAA group, Cavendish subgroup) ‘Giant Cavendish’, were ripened in a biotron at 25°C with ethylene during 4 days. Changes in mechanical properties of pulp were detected by a stress‐relaxation technique. The decrease in T 0 , the parameter for minimum stress‐relaxation time, began between day 0.5 and 1, while the decrease in initial stress began between day 0 and 0.5, suggesting that the decrease in elasticity and viscosity of pulp is a crucial physical event of pulp softening. Cellulose and moisture contents were about 3 and 780 mg (g fresh weight) −1 , respectively, which were unchanged during ripening. The decrease in starch content of cell materials and in uronic acid content of the pectic polysaccharides of the cell walls began between day 0.5 and 1. As regards the sugar composition of the hemicellulose fraction, decreases in arabinose, mannose and galactose contents began between day 0 and 0.5. The results show that the partial decrease in hemicelluloses preceded the breakdown of starch and suggest that the coordinated degradation of pectic and hemicellulosic polysaccharides and starch is the main cause for the pulp softening process.
Effects of apigenin and <i>tt</i>‐farnesol on glucosyltransferase activity, biofilm viability and caries development in rats (2002)

Propolis, a resinous hive product secreted by Apis mellifera bees, has been shown to reduce the incidence of dental caries in rats. Several compounds, mainly polyphenolics, have been identified in propolis. Apigenin and tt-farnesol demonstrated biological activity against mutans streptococci. We determined here their effects, alone or in combination, on glucosyltransferase activity, biofilm viability, and development of caries in rats. Sprague-Dawley rats were infected with Streptococcus sobrinus 6715 and treated topically twice daily as follows: (1) tt-farnesol, (2) apigenin, (3) vehicle control, (4) fluoride, (5) apigenin +tt-farnesol, and (6) chlorhexidine. Apigenin (1.33 mM) inhibited the activity of glucosyltransferases in solution (90-95%) and on the surface of saliva-coated hydroxyapatite beads (35-58%); it was devoid of antibacterial activity. tt-Farnesol (1.33 mM) showed modest antibacterial activity against biofilms and its effects on glucosyltransferases were minimal. The incidence of smooth-surface caries was significantly reduced by apigenin +tt-farnesol (60%), fluoride (70%), and chlorhexidine (72%) treatments compared to control (P < 0.05).
Covalent nano delivery systems for selective imaging and treatment of brain tumors (2017)

Nanomedicine is a rapidly evolving form of therapy that holds a great promise for superior drug delivery efficiency and therapeutic efficacy than conventional cancer treatment. In this review, we attempt to cover the benefits and the limitations of current nanomedicines with special attention to covalent nano conjugates for imaging and drug delivery in the brain. The improvement in brain tumor treatment remains dismal despite decades of efforts in drug development and patient care. One of the major obstacles in brain cancer treatment is the poor drug delivery efficiency owing to the unique blood-brain barrier (BBB) in the CNS. Although various anti-cancer agents are available to treat tumors outside of the CNS, the majority fails to cross the BBB. In this regard, nanomedicines have increasingly drawn attention due to their multi-functionality and versatility. Nano drugs can penetrate BBB and other biological barriers, and selectively accumulate in tumor cells, while concurrently decreasing systemic toxicity.
Renewable Electricity Futures Study - Volume 1: Exploration of High-Penetration Renewable Electricity Futures (2012)

The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/
A Control Approach For Real Time Human Grasp Simulation with Deformable Fingertips (2006)

This paper presents a control approach for human grasp simulation in a real-time context. We consider a 12-dof hand grasping quasi-rigid objects, either for fine manipulation or perturbation rejection. The objective is to translate and rotate the object with respect to non-sliding conditions. In order to improve the visual realism and the stability of the simulation, we use a locally deformable model on fingertips with friction. The resolution of contact forces is used for controlling the system with a set of 23 muscles. This paper presents also a new technique for solving the grasping force optimization problem, allowing real time simulation. This work is part of a virtual human project and combines robotic control experiments and theoretical laws of deformations in a global simulation
Crystal growth in X-ray-transparent plastic tubing: an alternative for high-throughput applications (2005)

A modified capillary-growth method is described that has substantial advantages for standard and high-throughput protein crystal growth. Protein-containing drops are injected into vapor-permeable flexible X-ray-transparent polyester tubing. The protein concentration in the drop increases over time by water transport through the tubing wall at a rate controlled by the wall thickness and ambient relative humidity. Unlike in conventional vapor-diffusion growth, the evaporation rate from the drop is constant over a longer time period, providing more suitable conditions for nucleation, and can be controlled by varying the tubing thickness and surrounding humidity. In situ X-ray diffraction can be performed at room temperature or, by flash-cooling, at low temperatures. Compared with glass capillaries or thick-wall plastic tubing, sealing and handling the tubing and extracting crystals are much easier.
THE FOUNDATION (2012)

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Fermentation as an advantageous route for the production of an acetate salt for roadway de-icing (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFermentation as an advantageous route for the production of an acetate salt for roadway de-icingChester W. Marynowski, Jerry L. Jones, Daniel Tuse, and Robert L. BoughtonCite this: Ind. Eng. Chem. Prod. Res. Dev. 1985, 24, 3, 457–465Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/i300019a025https://doi.org/10.1021/i300019a025research-articleACS PublicationsRequest reuse permissionsArticle Views114Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Tangible Augmented Reality for Computer Games (2003)

In this paper we attempt to demonstrate that Tangible Aug-mented Reality is a highly effective environment for certain types of multiplayer computer games. We show the useful-ness of this user interaction paradigm through both theoret-ical argumentation and presentation of our prototype sys-tem. During the development of this system we evaluated several variants of the interaction techniques necessary for the game, and we discuss the relative merits of some of them in this paper.
CoDAC: A compressive depth acquisition camera framework (2012)

Light detection and ranging (LIDAR) systems use time of flight (TOF) in combination with raster scanning of the scene to form depth maps, and TOF cameras instead make TOF measurements in parallel by using an array of sensors. Here we present a framework for depth map acquisition using neither raster scanning by the illumination source nor an array of sensors. Our architecture uses a spatial light modulator (SLM) to spatially pattern a temporally-modulated light source. Then, measurements from a single omnidirectional sensor provide adequate information for depth map estimation at a resolution equal that of the SLM. Proof-of-concept experiments have verified the validity of our modeling and algorithms.
On the determination of Pleistocene temperature from planktonic foraminifera (1975)

Other| April 01, 1975 On the determination of Pleistocene temperature from planktonic foraminifera W. H. Berger; W. H. Berger Scripps Inst. Oceanogr., La Jolla, Calif., United States Search for other works by this author on: GSW Google Scholar J. V. Gardner J. V. Gardner Search for other works by this author on: GSW Google Scholar Journal of Foraminiferal Research (1975) 5 (2): 102–113. https://doi.org/10.2113/gsjfr.5.2.102 Article history first online: 03 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Search Site Citation W. H. Berger, J. V. Gardner; On the determination of Pleistocene temperature from planktonic foraminifera. Journal of Foraminiferal Research 1975;; 5 (2): 102–113. doi: https://doi.org/10.2113/gsjfr.5.2.102 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentBy SocietyJournal of Foraminiferal Research Search Advanced Search This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not currently have access to this article.
Approaches to the Successful Design and Implementation of VR Applications (1994)

The successful design of virtual reality applications involves both and strategies. This talk will broadly outline these strategies: how bottom-up strategies are driven primarily by performance considerations; and how top-down strategies are driven primarily by the application task, the interaction metaphors, and the integration of the virtual environment. How to ensure these two approaches meet in the middle through Iterative design processes will be stressed. The discussion will be motivated by examples of both success and failure. The talk contains information bryson presented at SIGGRAPH '93 and Visualization '93, and is a high-level discussion of design principles for virtual reality. There will be essentially no discussion of virtual wind tunnel specific issues or any other matters relating to aerospace, the tutorial is a repeat of the tutorial Bryson and Steve Feiner presented at Visualization '93 In October 1993 in San Jose, CA, and will cite the virtual windtunnel only as an example.
Formation of sunflower oil emulsions stabilized by whey proteins with high-pressure homogenization (up to 350 MPa): effect of pressure on emulsion characteristics (2002)

Abstract A new ultra-high-pressure homogenizer was used to make very fine oil in water emulsions. The effect of pressures up to 350 MPa on sunflower oil (20%) in water emulsions was studied. The emulsifier used was whey protein concentrate (1.5%). The properties of the emulsions were characterized by laser light scattering (droplet size distribution) and coaxial cylinders rheometry (rheological behaviour). The protein adsorption fraction was obtained by a spectrophotometric method using bicinchoninic acid reagent. Significant modifications in the structure and the texture of the emulsions were observed as the pressure increased. No change was revealed by polyacrylamide gel electrophoresis of the whey protein within the pressure range studied. Microdifferential scanning calorimetry scans indicated that the changes of the structural and textural properties may be because of changes in the protein conformation.
Reactive Ion Etching of β-FeSi<sub>2</sub> with Inductively Coupled Plasma (2006)

A dry etching technique for a β-FeSi2 film on Si(111) was successfully developed. The technique is reactive ion etching (RIE) with inductively coupled plasma using CH4/O2/NH3/CHF3 discharge at a low pressure. It was found that CHF3 gas is indispensable in this etching technique, since CH4/O2/NH3 did not etch the film, and neither did SF6/O2, which is widely used for Si etching. Almost no further etching of the bottom Si substrate was observed and a carbon residual appeared on the surface, when the present RIE process using CH4/O2/NH3/CHF3 discharge was used to etch the entire β-FeSi2 film such that the Si substrate emerged. This experimental result shows a possibility of highly selective RIE for β-FeSi2/Si heterostructures.
Pharmacological aspects of pyrazoline derivatives from 2-hydroxy-butenolides. (1976)

A series of pyrazoline derivatives was synthetised and evaluated for toxicological and pharmacological effects; analgesic, hypnotic, anti-inflammatory, antipyretic and cardiovascular properties were screened. Tested compounds were found to have a low toxicity; one of them showed a good analgesic activity without side effects.
Adhesion and friction of thin metal films (1976)

Sliding friction experiments were conducted in vacuum with thin films of titanium, chromium, iron, and platinum sputter deposited on quartz or mica substrates. A single crystal hemispherically tipped gold slider was used in contact with the films at loads of 1.0 to 30.0 and at a sliding velocity of 0.7 mm/min at 23 C. Test results indicate that the friction coefficient is dependent on the adhesion of two interfaces, that between the film and its substrate and the slider and the film. There exists a relationship between the percent d bond character of metals in bulk and in thin film form and the friction coefficient. Oxygen can increase adhesive bonding of a metal film (platinum) to a substrate.
The Safety of Peanut Oral Immunotherapy in Peanut-Allergic Subjects in a Single-Center Trial (2012)

In this trial of OIT in adults and children, most reactions were mild.
New Developments in Optical Fabrication Techniques (1975)

Because of the demand for better performance in optical systems, there is a continuing effort to find more efficient ways of producing optics. Perkin-Elmer's involvement in developing new techniques for the fabrication of aspheric and flat surfaces has resulted in the generation of three machining methods: (1) computer-controlled polishing of aspheric surfaces, (2) continuous polishing of flat surfaces, and (3) single-point diamond tool machining of spheres and flats by means of the Precision Surface Generator. Optical flats larger than 20 inches in diameter have been produced that are flat to better than A /8 peak to valley. The Precision Surface Generator has successfully produced metal mirrors of aluminum, copper, and brass.
Robust low-distortion wideband CMOS current-follower (1999)

A wideband CMOS low-distortion current-follower is proposed. The circuit is suitable for low-voltage, high-frequency and low-distortion VLSI applications. The design avoids the use of current mirror(s) in the signal path in order to minimise the distortion caused by mismatched mirroring transistors. The circuit exhibits a large bandwidth, high linearity and low input resistance. Simulation results are provided.
Rapid derivation of genetically related mutants from embryonic cells harboring a recombinase-specific<i>Trp53</i>platform (2011)

Recombinase-mediated cassette exchange (RMCE) is a powerful method for achieving gene targeting repeatedly at a single mammalian locus. This approach could be applied to the efficient establishment of genetically related cell lines harboring different p53 mutations found in human tumors. To this end we generated a mouse strain called p53 Platform mice (PLF mice), containing PhiC31 integrase-specific attP sequences at the Trp53 locus. The attP sites flank a PGK-neo cassette that has replaced exons 2 to 9 of the endogenous murine p53 gene, generating a null allele. Electroporation of a fluorescence indicator plasmid into embryonic stem (ES) cell lines from PLF mice demonstrated that PhiC31 integrase-mediated cassette exchange (IMCE) can be achieved at > 60% efficiency without selecting against random insertion. To produce somatic cell lines with endogenously controlled expression of mutant p53, we performed IMCE in PLF murine embryonic fibroblasts (MEFs) with plasmid constructs containing human p53 gene sequences carrying specific tumor-associated missense mutations (A138V; G245S). The MEF cell lines produce the expected mutated mRNA transcripts and express p53 protein that is phosphorylated at serine 15 following DNA damage. Within a few weeks one can thus acquire a family of p53 mutant cell lines from the same population of primary cells, but each harboring a different mutation.
A successful maintenance approach in inflammatory acne with adapalene gel 0.1% after an initial treatment in combination with clindamycin topical solution 1% or after monotherapy with clindamycin topical solution 1% (2004)

The present study confirmed the importance of a maintenance therapy after a successful initial treatment and underlined the benefit of a combination therapy with a topical retinoid such as adapalene and a topical antibiotic in the treatment of inflammatory acne.
Clinical Aspects of Uraemic Polyneuropathy (1971)

In order to establish the relationship between uraemic polyneuropathy and impairment of renal function, 83 patients with severe renal insufficiency not treated by maintenance dialysis were neurologically examined, most of them repeatedly in the course of their disease. Signs of neuropathy were found only when the creatinine clearance was 5 ml/min or less. The risk of incapacitating neuropathy was present in patients with a creatinine clearance of 3 ml/min or less. Polyneuropathy was found most frequently in patients with the highest blood urea and creatinine levels and the lowest creatinine clearances, but the duration of the period during which renal insufficiency had been severe appeared to be of influence as well. Polyneuropathy could be correlated more closely with the level of breakdown products of protein metabolism in the blood than with the blood creatinine level. The motor conduction velocity of the lateral popliteal nerve was examined in 50 patients. When polyneuropathy progressed, the conduction velocity fell to 50% of the normal value. The protein level of the CSF was raised in most patients with a severe polyneuropathy. Polyneuropathy was assessed in 20 patients treated by maintenance dialysis; it was compared to polyneuropathy in patients without this treatment.