gebhart/patrepeval huggingface dataset:
Femtosecond electron imaging of defect-modulated phonon dynamics (2016)

Precise manipulation and control of coherent lattice oscillations via nanostructuring and phonon-wave interference has the potential to significantly impact a broad array of technologies and research areas. Resolving the dynamics of individual phonons in defect-laden materials presents an enormous challenge, however, owing to the interdependent nanoscale and ultrafast spatiotemporal scales. Here we report direct, real-space imaging of the emergence and evolution of acoustic phonons at individual defects in crystalline WSe2 and Ge. Via bright-field imaging with an ultrafast electron microscope, we are able to image the sub-picosecond nucleation and the launch of wavefronts at step edges and resolve dispersion behaviours during propagation and scattering. We discover that the appearance of speed-of-sound (for example, 6 nm ps(-1)) wavefronts are influenced by spatially varying nanoscale strain fields, taking on the appearance of static bend contours during propagation. These observations provide unprecedented insight into the roles played by individual atomic and nanoscale features on acoustic-phonon dynamics.
Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells (1993)

The melanoma-associated disialogangliosides 9(7)-O-acetyl-GD3 and 9(7)-O-acetyl-GD2 have been structurally well characterized. However, the compartmentalization and sequence of action of the biosynthetic activities responsible for synthesizing these molecules remain obscure. Here, we have studied the spatial and temporal interrelationships among the activities responsible for the later stages of ganglioside biosynthesis and those for O-acetylation in cultured human melanoma cells. First, brefeldin A treatment was used to separate biosynthetic steps into compartments distal or proximal to the transport block imposed by the drug. In keeping with prior reports, GM2/GD2 synthase was consistently rendered inaccessible to its acceptors GM3 and GD3. In contrast, the effect on GD3 biosynthesis was cell line-specific. Synthesis of GD3 was nearly abrogated in two lines, while it accumulated in a third line. This indicates that the spatial organization of ganglioside processing activities can vary even between similar cell lines. However, in all cell lines studied, the ratio of 9(7)-O-acetyl-GD3 to GD3 was not changed by brefeldin A, indicating that the majority of ganglioside O-acetyltransferase activity is co-localized with GD3 biosynthetic activity in the same Golgi subcompartment(s). As an alternative approach, Golgi-enriched fractions from melanoma cells were incubated with radiolabeled and nonlabeled nucleotide sugars or acetyl-CoA. In these preparations, biosynthesis is dependent upon the co-localization of appropriate sugar nucleotide transporters, glycosyltransferases, and acceptors that are endogenously present within intact topologically correct compartments. Incubations with CMP-Neu5Ac and acetyl-CoA corroborated the results with brefeldin A, co-localizing ganglioside O-acetyltransferase activity in compartments where GD3 biosynthesis takes place. Analyses with CMP-Neu5Ac and UDP-GalNAc showed that GD2 and GD3 synthesis occur in partially overlapping compartments. Labeling with acetyl-CoA and UDP-GalNAc indicated that although labeled acetate can be transferred from acetyl-CoA directly to GD2, ganglioside O-acetyltransferase activity does not substantially overlap with the biosynthetic compartment(s) for GD2. Instead, O-acetyl-GD3 appears to be co-localized with the compartment of GD2 biosynthesis and serves as an acceptor for GD2 synthase. Thus, both 9-O-acetyl-GD3 and GD2 can be precursors of 9-O-acetyl-GD2, but apparently in distinct compartments.
Activation of Complement by <i>Schistosoma Mansoni</i> Schistosomula: Killing of Parasites by the Alternative Pathway and Requirement of IgG for Classical Pathway Activation (1979)

Living Schistosoma mansoni schistosomula incubated with normal chicken, guinea pig, human, and monkey sera were killed after 4 hr contact at 37 degrees C. The following data indicate that this action is dependent on the activation of the alternative complement pathway (AP): a) the inactivity of RB, RD, and zymosan-treated serum against schistosomula; b) the partial activity of RD restored in FD; c) the full effect of the C4-deficient guinea pig, C2-deficient human, and the agammaglobulinemic human sera; d) the consumption of both the AP and FB after the incubation of NHS with schistosomula; e) the detection of C3d breakdown product during the contact of the C2-deficient human serum with these young parasites. Killing by serum was decreased as the immature schistosomes developed and was completely absent against 4-day-old lung schistosomula (LS). In other experiments, it was demonstrated that schistosomula, in the presence of IgG, were able to initiate complement activation also through the classical pathway (CP). However, the CP does not appear to play a role in the schistosomulicidal activity of complement. The in vivo relevance of these observations is considered.
Network-Based Real-time Integrated Fire Detection and Alarm (FDA) System with Building Automation (2017)

Fire alarm systems have become increasingly an important lifesaving technology in many aspects, such as applications to detect, monitor and control any fire hazard. A large sum of money is being spent annually to install and maintain the fire alarm systems in buildings to protect property and lives from the unexpected spread of fire. Several methods are already developed and it is improving on a daily basis to reduce the cost as well as increase quality. An integrated Fire Detection and Alarm (FDA) systems with building automation was studied, to reduce cost and improve their reliability by preventing false alarm. This work proposes an improved framework for FDA system to ensure a robust intelligent network of FDA control panels in real-time. A shortest path algorithmic was chosen for series of buildings connected by fiber optic network. The framework shares information and communicates with each fire alarm panels connected in peer to peer configuration and declare the network state using network address declaration from any building connected in network. The fiber-optic connection was proposed to reduce signal noises, thus increasing large area coverage, real-time communication and long-term safety. Based on this proposed method an experimental setup was designed and a prototype system was developed to validate the performance in practice. Also, the distributed network system was proposed to connect with an optional remote monitoring terminal panel to validate proposed network performance and ensure fire survivability where the information is sequentially transmitted. The proposed FDA system is different from traditional fire alarm and detection system in terms of topology as it manages group of buildings in an optimal and efficient manner.Introduction
Toward single-shot measurement of a broadband ultrafast continuum (2008)

We discuss the problem of measuring the intensity and phase of a broadband continuum in a single shot, considering three possible methods, and perform preliminary measurements using one of them. Our measurements use transient-grating cross-correlation frequency-resolved optical gating (TG XFROG) with a third-order nonlinear medium, which currently can phase match over 300 nm simultaneously. We demonstrate this technique for a continuum generated in bulk fused silica that is 12.5 mm thick. Due to limited reference-pulse energy, we do not achieve a true single-shot measurement, instead averaging over approximately five shots. The retrieved trace and spectrum contain fine structure, and the retrieved temporal phase is mainly quadratic.
Design of low-voltage front-end interface for switched-op amp circuits (2001)

Switched-op amp technique is an effective technique for designing low-voltage switched-capacitor circuits. The only drawback with this approach is the difficulty in designing the front-end interface to the external input, In this paper, front-end interface structures with wide signal swing and no voltage boosting are proposed. Based on a conventional 1.2-/spl mu/m CMOS process, a front-end interface was designed and implemented. For a 1-V supply, the interface dissipates 80 /spl mu/W. The track mode THD was measured to be -78 dB for a 600-mV peak-to-peak output suing, and the maximum sampling rate was measured to be 600 kS/s for a capacitive load of 20 pF.
Effective note‐taking (1986)

A report commissioned by Parker in the USA into student note‐taking points to bad note‐taking as a prime cause of failure to achieve the level of academic success of which a student is capable. The report surveyed a wide selection of university teachers across the country, and their observations can be summed up as follows:
Halved Vivaldi Antenna With Reconfigurable Band Rejection (2011)

This letter presents a Vivaldi antenna having the capability of dynamically rejecting interferers, mainly aiming at multistandard communication with dynamic frequencies allocation. Only half of the Vivaldi is used and placed over a ground plane, which is suitable to vehicular communication. The rejection Alter is integrated to the antenna real estate and consists of two microstrip resonators and two varactor diodes coupled to the slot of the Vivaldi. It is simply biased by applying the control voltage at the antenna RF port. Good matching is achieved from 2.5 to 8 GHz while rejecting a band whose central frequency can be tuned from 1.8 to 5.8 GHz. Simulated and measured return loss, gain, and radiation patterns are presented. The measured gain rejection in the direction of the radiation maximum is about 20 dB or better in the entire tuning range.
A New Nonpeptide Tachykinin NK1 Receptor Antagonist Isolated from the Plants of Compositae. (2002)

To find new tachykinin NK1 receptor antagonists from natural sources, we examined the tachykinin antagonist activity in the extracts of approximately 200 species of plants by the use of isolated guinea pig ileum. As a result, we discovered a novel and potent NK1 receptor antagonist in the extract of dried flowers of Matricaria chamomilla L. (chamomile). The structure of the antagonist was established as N1,N5,N10,N14-tetrakis[3-(4-hydroxyphenyl)-2-propenoyl]-1,5,10,14-tetraazatetradecane (tetracoumaroyl spermine, 1a). The Ki values of 1a, estimated from the inhibitory action on the substance P (SP)-induced contraction of the guinea pig ileum and the inhibition of the binding of [3H][Sar9, Met(O2)11]SP to human NK1 receptors, were 21.9 nM and 3.3 nM, respectively. 1a is the first potent NK1 receptor antagonist from natural sources and it has a unique structure of a polyacylated spermine. 1a was concentrated in pollen of Matricaria chamomilla L. and was also found in the extracts of flowers of other four species of Compositae. In addition, we found N1,N5,N10-tris[3-(4-hydroxyphenyl)-2-propenoyl]-1,5,10,14-tetraazatetradecane (2) as a new compound in the extract of flowers of Matricaria chamomilla L., which did not exhibit any tachykinin antagonist activity. A number of related compounds were synthesized, and the structure-activity relationship was studied.
Doppler Color Flow Mapping of the Fetal Heart (1986)

The recently developed innovative technique of Doppler color flow mapping permits real time visualization of blood flow patterns superimposed on two-dimensional echocardiographic images of the heart. This study demonstrates, for the first time, the usefulness of this technique in characterizing fetal cardiac dynamics.
10,10-Difluoro-13-dehydroprostacyclin: a chemically and metabolically stabilized potent prostacyclin (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT10,10-Difluoro-13-dehydroprostacyclin: a chemically and metabolically stabilized potent prostacyclinJosef Fried, D. K. Mitra, M. Nagarajan, and M. M. MehrotraCite this: J. Med. Chem. 1980, 23, 3, 234–237Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/jm00177a003https://doi.org/10.1021/jm00177a003research-articleACS PublicationsRequest reuse permissionsArticle Views326Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Subsurface Imaging with Widefield and Confocal Numerical Aperture Increasing Lens Microscopes (2006)

We obtain lateral spatial resolutions of 0.88 mum and 0.29 mum with custom infrared widefield and confocal numerical aperture increasing lens microscopes, respectively, when imaging subsurface structures. We discuss the relative advantages of each microscope
Suzuki–Miyaura Cross‐Coupling of Unprotected Halopurine Nucleosides in Water—Influence of Catalyst and Cosolvent (2006)

Abstract Reaction conditions for the Suzuki–Miyaura cross‐coupling of unprotected halopurine nucleosides with arylboronic acids in aqueous media were investigated. A series of arylated purine nucleosides was prepared in water without an organic cosolvent, using either Pd(PPh3)4 or Pd(OAc)2/TPPTS as the catalyst.
Automatic registration of color images to 3D geometry (2009)

We present an approach to automatically register a large set of color images to a 3D geometric model. The problem arises from the modeling of real-world environments, where surface geometry is acquired using range scanners whereas the color information is separately acquired using untracked and uncalibrated cameras. Our approach constructs a sparse 3D model from the color images using a multiview geometry technique. We project special light patterns onto the scene surfaces to increase the robustness of the multiview geometry reconstruction. The sparse model is then approximately aligned with the detailed model. Planes found in the detailed model are exploited to refine the registration. Finally, the registered color images are mapped to the detailed model using weighted blending, with careful consideration of occlusion and the preservation of image details.
Direct write electron beam patterning of DNA complex thin films (2008)

The authors report on the first use of direct write electron beam lithography (DW-EBL) patterning of DNA-based materials. Water insoluble and organic solvent soluble DNA:CTMA complexes were formed by reaction of DNA polymers with cationic surfactants and other molecular species. Thin films with thicknesses ranging from 85 to 300 nm were prepared by spin coating. DW-EBL was conducted using a Raith 150 system. The resulting exposed areas demonstrated either positive or negative resist properties depending on development solution. The characteristics of the DNA:CTMA material as a patternable electron sensitive resist medium are presented for different exposure conditions (10–30 kV), development conditions, structure sizes (100 nm to 20 μm), and structure complexities. Contrast values of ∼2 have been obtained in both positive and negative resist modes. Both simple (20 μm diameter circle and square) and complex (Fresnel lens) patterns with nanometer scale features (&lt;100 nm) in DNA films are possible using this method.
Simple, effective computation of principal eigenvectors and their eigenvalues and application to high-resolution estimation of frequencies (1986)

We present the results of an investigation of the Prony-Lanczos (P-L) method [14], [38] and the power method [39] for simple computation of approximations to a few eigenvectors and eigenvalues of a Hermitian matrix. We are motivated by realization of high-resolution signal processing in an integrated circuit. The computational speeds of the above methods are analyzed. They are completely dependent on the speed of a matrix-vector product operation. If only a few eigenvalues or eigenvectors are needed, the suggested methods can substitute for methods of the LINPACK or EISPACK subroutine libraries. The accuracies of the suggested methods are evaluated using matrices formed from simulated data consisting of two sinusoids plus Gaussian noise. Comparisons are made to the corresponding eigenvalues and eigenvectors obtained using LINPACK as a reference. Also, the accuracies of frequency estimates obtained from the eigenvectors are compared.
Optical imaging of the spatiotemporal dynamics of cerebral blood flow and oxidative metabolism in the rat barrel cortex (2004)

Oxidative metabolism and cerebral blood flow (CBF) are two of the most important measures in neuroimaging. However, results from concurrent imaging of the two with high spatial and temporal resolution have never been published. We used flavoprotein autofluorescence (AF) and laser speckle imaging (LSI) in the anaesthetized rat to map oxidative metabolism and CBF in response to single vibrissa stimulation. Autofluorescence responses reflecting oxidative metabolism demonstrated a fast increase with a delay of 0.1 s. The sign-reversed speckle contrast reflecting CBF started to rise with a delay of 0.6 s and reached its maximum 1.4 s after the stimulation offset. The fractional signal changes were 2.0% in AF and 9.7% in LSI. Pixelwise modelling revealed that CBF maps spread over an area up to 2.5-times larger than metabolic maps. The results provide evidence that the increase in cerebral oxidative metabolism in response to sensory stimulation is considerably faster and more localized than the CBF response. This suggests that future developments in functional imaging concentrating on the metabolic response promise an increased spatial resolution.
Missense Polymorphisms in Matrix Metalloproteinase Genes and Skin Cancer Risk (2008)

Matrix metalloproteinases (MMP) degrade various components of the extracellular matrix, and their overexpression has been implicated in tumor progression. Nonsynonymous single nucleotide polymorphisms (SNPs) lead to amino acid substitutions that can alter the function of the encoded protein. We evaluated the associations of six nonsynonymous SNPs in the MMP3, MMP8, and MMP9 genes with skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 normal controls. We observed that the MMP9 Arg668Gln polymorphism was significantly associated with a decreased risk of SCC. Compared with the Arg/Arg group, the multivariate odds ratio was 0.67 (95% confidence interval, 0.47-0.97) for the Arg/Gln group and 0.21 (95% confidence interval, 0.05-0.97) for the Gln/Gln group (P(trend) = 0.004). We did not observe any association of this SNP with the risks of melanoma and basal cell carcinoma. No associations were found for other SNPs with skin cancer risk. This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development.
Thomson-Backscattered X Rays From Laser-Accelerated Electrons (2006)

We present the first observation of Thomson-backscattered light from laser-accelerated electrons. In a compact, all-optical setup, the "photon collider," a high-intensity laser pulse is focused into a pulsed He gas jet and accelerates electrons to relativistic energies. A counterpropagating laser probe pulse is scattered from these high-energy electrons, and the backscattered x-ray photons are spectrally analyzed. This experiment demonstrates a novel source of directed ultrashort x-ray pulses and additionally allows for time-resolved spectroscopy of the laser acceleration of electrons.
High-speed short-range systems for wireless personal area networks (2009)

With the advance in wireless technology, latest generation of wireless personal area networks (WPANs) can provide a data rate of hundreds (or even thousands) of Mbps at a distance of less than 10 meters. This paper reports the latest development of high-speed WPANs. Systems like Certified Wireless USB, Bluetooth 3.0, WirelessHD, and TransferJet will be reported in this paper. Since ultra-wideband (UWB) technology has been adopted in many high-speed WPANs, this paper also discusses technical challenges and applications of UWB-based WPANs.
Direct amplitude modulation of short-cavity GaAs lasers up to <i>X</i>-band frequencies (1983)

Experimental and theoretical studies indicate that a high-frequency laser with bandwidths up to X-band frequencies (≳10 GHz) should be one having a short cavity with a window structure, and preferably operating at low temperatures. These designs would accomplish the task of shortening the photon lifetime, increasing the intrinsic optical gain, and increasing the internal photon density without inflicting mirror damage. A modulation bandwidth of &gt;8 GHz has been achieved using a 120-μm laser without any special window structure at room temperature.
Designing low permeability, optical-grade silicone systems: guidelines for choosing a silicone based on transmission rates for barrier applications (2012)

Unprotected electronic components exposed to moisture from high humidity may fail due to corrosion of metal leads or other unfavorable reactions on chemically sensitive components. This is of high interest for silicones that encapsulate Light Emitting Diodes (LEDs) dies. For these applications, moisture and oxygen may react with materials, such as phosphor, used to make white LEDs for back-lighting applications and decrease or change the light output and color over time. Of the polymeric adhesives and sealants commercially available, silicones are used for their thermal stability, clarity, and comparably low modulus that provides stress relief during thermal cycling. In addition, silicones are also known to be very permeable to low molecular weight gases such as water vapor and oxygen. Recently, several types of silicones were tested for the oxygen and water vapor transmission rates, and it was found that they can have drastically different results. Silicone properties strongly affecting permeability are polymer backbone chemistry, crosslink density and fillers. Phenyl (C<sub>6</sub>H<sub>5</sub>) and trifluoropropyl (CF<sub>3</sub>CH<sub>2</sub>) groups are used to optimize the refractive index of optically clear silicones. The effect of chemical composition on the water vapor transfer rate (WVTR) and the oxygen transfer rate (OTR) at 40<sup>0</sup> C and 90% Relative Humidity was investigated on several silicones with various refractive indices and compared to polydimethylsiloxane (PDMS) with similar durometers. It was found that polymer backbone chemistry had a significant influence on the permeation rates and will assist in material selection when designing for low-permeable barriers to improve package reliability.