gebhart/patrepeval huggingface dataset:
Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy. (1987)

Lactitol, an unabsorbed sugar with defined laxative threshold and superior taste properties has been suggested as an alternative to lactulose in the treatment of hepatic encephalopathy. In the present study we have compared the colonic metabolism of the two sugars using an in vitro faecal incubation system. Both sugars were readily metabolised by faecal bacteria producing volatile fatty acids and the metabolism was inhibited by neomycin. The effect of lactitol and lactulose on terminal ileal and colonic pH was monitored in six normal subjects using a radiotelemetry technique. Both sugars significantly lowered right colonic pH (basal -6.51 +/- 0.48 vs lactitol -5.63 +/- 0.50; lactulose -5.18 +/- 0.82, p less than 0.05). The pH of rest of the colon and terminal ileum was unaffected. Neomycin given concurrently with lactulose abolished acidification of right colon. As lactitol and lactulose have similar effects within the colon, lactitol would appear to have a role in the treatment of hepatic encephalopathy. As neomycin antagonises the effect of lactulose in the colon, its concurrent use may be less effective in the treatment of hepatic encephalopathy.
Dynamic partial search scheme for stochastic codebook of FS1016 CELP coder (1995)

The authors present a new classified dynamic partial search structure for the stochastic codebook of the FS1016 CELP coder to replace the fixed partial search for selecting the best excitation vector of the stochastic codebook. In the proposed scheme, the conventional one-stage stochastic codebook search is substituted with a two-stage dynamic method for reducing the computational complexity without degrading the voice quality. The establishment of this structure is based on two classifiers, one for the line spectrum pairs (LSP) of the input signals, and the other for the autocorrelation coefficients (AC) of the stochastic codebook search target. In addition, the stochastic codebook is classified into K subcodebooks, and with these two classifiers it is possible to determine dynamically which subcodebook needs to be searched. This method achieves a reduction in the search procedure by a factor of 2-8. The efficiency of these two classifiers is discussed and the comparison of the performance between the fixed partial search and the proposed technique is also addressed.
Emerging Evidence for Platelets as Immune and Inflammatory Effector Cells (2014)

While traditionally recognized for their roles in hemostatic pathways, emerging evidence demonstrates that platelets have previously unrecognized, dynamic roles that span the immune continuum. These newly recognized platelet functions, including the secretion of immune mediators, interactions with endothelial cells, monocytes, and neutrophils, toll-like receptor (TLR) mediated responses, and induction of neutrophil extracellular trap formation, bridge thrombotic and inflammatory pathways and contribute to host defense mechanisms against invading pathogens. In this focused review, we highlight several of these emerging aspects of platelet biology and their implications in clinical infectious syndromes.
New design techniques yield low power, high resolution delta-sigma and SAR ADCS for process control, medical, seismic and battery-powered applications (1991)

Design innovation using CMOS technology has resulted in an array of new high resolution analog-to-digital converters (ADCs). New design techniques such as on-chip self-calibration have brought about more accurate successive approximation register (SAR) and delta-sigma ADCs. Three ADCs are discussed. These new chips are designed with proven CMOS processes and result in superior performance with very low power dissipation. The three A-to-D converters are: (1) 16-bit four channel DC measurement delta-sigma; (2) 16-bit self-calibrating 25 kHz SAR. (3) 24-bit variable bandwidth delta-sigma converter. >
BIFURCATION AND CHAOS IN COUPLED BVP OSCILLATORS (2004)

Bonhöffer–van der Pol(BVP) oscillator is a classic model exhibiting typical nonlinear phenomena in the planar autonomous system. This paper gives an analysis of equilibria, periodic solutions, strange attractors of two BVP oscillators coupled by a resister. When an oscillator is fixed its parameter values in nonoscillatory region and the others in oscillatory region, create the double scroll attractor due to the coupling. Bifurcation diagrams are obtained numerically from the mathematical model and chaotic parameter regions are clarified. We also confirm the existence of period-doubling cascades and chaotic attractors in the experimental laboratory.
Medicinal Plants Can Be Good Source of Antioxidants: Case Study in Cameroon (2007)

Extracts of 42 medicinal plants used for the treatment of anaemia, diabetes, AIDS, malaria and obesity were screened for phytochemical substances and antioxidant potentials. The plant extracts were prepared as hydrolysed (for total antioxidant) and non-hydrolysed (for free antioxidant). Extracts were analysed using three different assay methods for antioxidant analysis: Folin (Folin Ciocalteu reagent), FRAP (Ferric Reducing Antioxidant Power) and DPPH (1,1-diphenyl-2-picrylhydrazyl). The leaves of Alchornea cordifolia showed the highest antioxidant properties as determined by both Folin and FRAP free antioxidant, followed by Dacryodes edulis and Ocimum basilicum in FRAP and by Dacryodes edulis, Harungana madagascariensis for Folin and DPPH method. For total antioxidant activity, Alchornea cordifolia was ranked first followed by Dacryodes edulis, Harungana madagascariensis, Ocimum basilicum for the FRAP method while for the Folin method Harungana madagascariensis occupied the first position followed by Cylicodiscus gabunensis, Ocimum basilicum, Coleus coprosifolius, Alchornea cordifolia, Dacryodes edulis. All the plants show some antioxidant activity irrespective of the method used. The phytochemical studies revealed the presents of important bioactive constituents with antioxidant activity that may have some medicinal properties.
Cooperative study in the evaluation of therapy in multiple sclerosis; ACTH vs placebo in acute exacerbations (1968)

The problems encountered in evaluating the effectiveness of treatment methods in multiple sclerosis are well recognized. They result in large part from the nature of the disease, which is characterized by a variable course and many different clinical manifestations. It has been estimated that approximately twothirds of multiple sclerosis patients experience a remission of symptoms at some time during their illness. Many forms of treatment have been proposed with claims of beneficial results for patients at all stages of the disease. Yet, most of these regimens are generally believed to be useless. If the empirical search for an effective treatment for multiple sclerosis is to have any chance of success, it is apparent that a reliable method of accurate assessment must be developed.

In 1960, a symposium concerned with the evaluation of drug therapy in neurological and sensory diseases recognized the many serious difficulties involved in clinical trials of therapy in multiple sclerosis including those pertaining to the conduct of cooperative studies.1 In the months following that symposium, an Ad Hoc committee agreed upon certain diagnostic criteria, scoring systems and principles of design for a suitable protocol for such clinical trials.2 The work of the Ad Hoc committee provided the basis for a subsequently designed protocol for a cooperative study utilizing ACTH vs placebo in the treatment of multiple sclerosis patients in acute exacerbations. A group of neurologists representing ten university treatment centers undertook a cooperative study utilizing this protocol beginning in April 1965. This preliminary report, based on observations of the first 135 cases entered, pre sents the characteristics of the study, demonstrates that adequate randomization of patients can be obtained in this disease and describes means for reasonably accurate evaluation of the many clinical changes seen in multiple sclerosis patients under treatment. Because the study is …
Dose Prediction with U-net: A Feasibility Study for Predicting Dose Distributions from Contours using Deep Learning on Prostate IMRT Patients. (2017)

With the advancement of treatment modalities in radiation therapy for cancer patients, outcomes have improved, but at the cost of increased treatment plan complexity and planning time. The accurate prediction of dose distributions would alleviate this issue by guiding clinical plan optimization to save time and maintain high quality plans. We have modified a convolutional deep network model, U-net (originally designed for segmentation purposes), for predicting dose from patient image contours of the planning target volume (PTV) and organs at risk (OAR). We show that, as an example, we are able to accurately predict the dose of intensity-modulated radiation therapy (IMRT) for prostate cancer patients, where the average Dice similarity coefficient is 0.91 when comparing the predicted vs. true isodose volumes between 0% and 100% of the prescription dose. The average value of the absolute differences in [max, mean] dose is found to be under 5% of the prescription dose, specifically for each structure is [1.80%, 1.03%](PTV), [1.94%, 4.22%](Bladder), [1.80%, 0.48%](Body), [3.87%, 1.79%](L Femoral Head), [5.07%, 2.55%](R Femoral Head), and [1.26%, 1.62%](Rectum) of the prescription dose. We thus managed to map a desired radiation dose distribution from a patient's PTV and OAR contours. As an additional advantage, relatively little data was used in the techniques and models described in this paper.
Integrated Device for Online Sample Buffer Exchange, Protein Enrichment, and Digestion (2010)

An integrated sample treatment device, composed of a membrane interface and a monolithic hybrid silica based immobilized enzymatic reactor (IMER), was developed for the simultaneous sample buffer exchange, protein enrichment, and online digestion, by which for the sample buffer, the acetonitrile content was reduced to approximately 1/10 of the initial one, and the pH value was adjusted from approximately 3.0 to approximately 8.0, compatible for online trypsin digestion. Furthermore, the signal intensity of myoglobin digests was improved by over 10 times. Such an integrated device was successfully applied to the online treatment of three protein eluates obtained by reverse-phase liquid chromatography (RPLC) separation, followed by further protein digest analysis with microreverse-phase liquid chromatography-electrospray ionization-tandem mass spectrometry (microRPLC-ESI-MS/MS). The experimental results showed that the performance of such an integrated sample treatment device was comparable to that of the traditional offline sample treatment method, including lyophilization and in-solution digestion. However, the consumed time was reduced to 1/192. All these results demonstrate that such an integrated sample treatment device could be further online coupled with protein separation, peptide separation, and identification, to achieve high-throughput proteome analysis.
Early Pathophysiological Features in Canine Renal Papillary Necrosis Induced by Nefiracetam (2005)

To ascertain the early pathophysiological features in canine renal papillary necrosis (RPN) caused by the neurotransmission enhancer nefiracetam, male beagle dogs were orally administered nefiracetam at 300 mg/kg/day for 4 to 7 weeks in comparison with ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), at 50 mg/kg/day for 5 weeks. During the dosing period, the animals were periodically subjected to laboratory tests, light-microscopic, immunohistochemical, and electron-microscopic examinations and/or cyclooxygenase (COX)-2 mRNA analysis. In laboratory tests, a decrease in urinary osmotic pressure and increases in urine volume and urinary lactate dehydrogenase (LDH) level were early biomarkers for detecting RPN. Light-microscopically, nefiracetam revealed epithelial swelling and degeneration in the papillary ducts in week 7, while ibuprofen displayed degeneration and necrosis in the papillary interstitium in week 5. In immunohistochemical staining with COX-2 antibody, nefiracetam elicited a positive reaction within interstitial cells around the affected epithelial cells in the papillary ducts (upper papilla) in week 7, and ibuprofen positively reacted within interstitial cells adjacent to the degenerative and/or necrotic lesions in week 5. Ultrastructurally, nefiracetam exhibited reductions of intracellular interdigitation and infoldings of epithelial cells in the papillary ducts, whereas ibuprofen showed no changes in the identical portions. Thus, the early morphological change in the papilla brought about by nefiracetam was quite different from that elicited by ibuprofen. By the renal papillary COX-2 mRNA expression analysis, nefiracetam exceedingly decreased its expression in week 4, but markedly increased it in week 7, suggesting an induction of COX-2 mRNA by renal papillary lesions. These results demonstrate that the epithelial cell in the papillary ducts is the primary target site for the onset of RPN evoked by nefiracetam.
Inhibition of T–Cell Responses by Hepatic Stellate Cells Via B7–H1-Mediated T–Cell Apoptosis in Mice (2004)

In the injured liver, hepatic stellate cells (HSCs) secrete many different cytokines, recruit lymphocytes, and thus participate actively in the pathogenesis of liver disease. Little is known of the role of HSCs in immune responses. In this study, HSCs isolated from C57BL/10 (H2b) mice were found to express scant key surface molecules in the quiescent stage. Activated HSCs express major histocompatibility complex class I, costimulatory molecules, and produce a variety of cytokines. Stimulation by interferon gamma (IFN-gamma) or activated T cells enhanced expression of these molecules. Interestingly, addition of the activated (but not quiescent) HSCs suppressed thymidine uptake by T cells that were stimulated by alloantigens or by anti-CD3-mediated T-cell receptor ligation in a dose-dependent manner. High cytokine production by the T cells suggests that the inhibition was probably not a result of suppression of their activation. T-cell division was also found to be normal in a CFSE dilution assay. The HSC-induced T-cell hyporesponsiveness was associated with enhanced T-cell apoptosis. Activation of HSCs was associated with markedly enhanced expression of B7-H1. Blockade of B7-H1/PD-1 ligation significantly reduced HSC immunomodulatory activity, suggesting an important role of B7-H1. In conclusion, the bidirectional interactions between HSCs and immune cells may contribute to hepatic immune tolerance.
A 700MHz 2T1C embedded DRAM macro in a generic logic process with no boosted supplies (2011)

6T SRAMs have been the embedded memory of choice for modern microproces sors due to their logic compatibility, high speed, and refresh-free operation. The relatively large cell size and conflicting requirements for read and write at low operating voltages make aggressive scaling of 6T SRAMs challenging in sub 22nm. Recently, 1T1C embedded DRAMs (eDRAMs) have replaced SRAMs in several server applications reducing the cache area and improving performance. Difficulties in scaling the trench capacitor and the additional process steps involved in manufacturing the thick oxide access devices are currently limiting the wide spread adoption of 1T1C technology. Gain cells have features such as decoupled read and write paths, a nondestructive read, and a 2X higher bit-cell density than a 6T SRAM, making them a strong contender for future embedded memories. However, the boosted supplies needed for robust operation necessitates thick oxide devices to prevent gate reliability issues in gain cells. Although this would lead to a larger bit-cell size and decreased macro perform ance, these limitations have been overlooked in the past. In this paper, we pres ent the following circuit techniques for realizing a truly logic compatible (i.e. thin oxide only implementation) gain cell eDRAM with no boosted supplies; (i) a 2T1C gain cell featuring a beneficial couple-up read and a preferential couple down write, (ii) a single-ended 7T SRAM to repair weak gain cells, and (iii) a storage voltage monitor capable of tracking PVT and cell retention time for adap tive refresh control.
Carrier Distribution and Dynamics of Nanocrystal Solids Doped with Artificial Atoms (2010)

Single component and multicomponent nanocrystal (NC) solids represent an exciting new form of condensed matter, as they can potentially capture not only the quantum features of the individual building blocks but also novel collective properties through coupling of NC components. Unlike bulk semiconductors, however, there is no current theory for how introduction of dopants will impact the electronic structure and transport properties of NC solids. Empirically, it is known that in semiconductor NC systems, mixing two different materials of NCs electronically dopes the film. However, it has been challenging to connect the macroscopic measurements of doping effects on transport behavior to a microscopic understanding of how the identity, placement, and abundance of dopants impact these measurements. In this Letter, we report the first temperature-dependent thermopower measurements in doped and undoped NC solids. In combination with temperature-dependent electrical conductivity measurements, how the doping affects the carrier concentration as well as mobility is explored exclusively. These complementary measurements serve as a unique electronic spectroscopy tool to quantitatively reveal the energetics of carriers and electronic states in NC solids.
Antitumor Agents. 199. Three-Dimensional Quantitative Structure−Activity Relationship Study of the Colchicine Binding Site Ligands Using Comparative Molecular Field Analysis (2000)

Inhibitors of tubulin polymerization interacting at the colchicine binding site are potential anticancer agents. We have been involved in the synthesis of a number of colchicine site agents, such as thiocolchicinoids and allocolchicinoids, which are colchicine analogues, and 2-phenyl-quinolones and 2-aryl-naphthyridinones, which are the amino analogues of cytotoxic antimitotic flavonoids. The most cytotoxic of the latter compounds strongly inhibit binding of radiolabeled colchicine to tubulin, and these agents therefore probably bind in the colchicine site of tubulin. We have applied conventional CoMFA and q(2)-GRS CoMFA to identify the essential structural requirements for increasing the ability of these compounds to form tubulin complexes. The CoMFA model for the training set of 51 compounds yielded cross-validated R(2) (q(2)) values of 0.637 for conventional CoMFA and 0.692 for q(2)-GRS CoMFA. The predictive power of this model was confirmed by successful activity prediction for a test set of 53 compounds with known potencies as inhibitors of tubulin polymerization. The activities of 88% of the compounds were predicted with absolute value of residuals of less than 0.5. The predictive q(2) values were 0.546 for conventional CoMFA and 0.426 for q(2)-GRS CoMFA. The conventional CoMFA model with the highest predictive q(2) (0.546) was analyzed in detail in terms of underlying structure-activity relationships.
Instrument an Off-Shelf CCD Imaging Sensor Into a Handheld Multispectral Video Camera (2011)

In this letter, we report the feasibility study of converting an ordinary off-shelf charge-coupled device (CCD) imaging sensor into a multispectral imaging instrument, using the multispectral bruises detection as an example. The resulting handheld device is capable of producing in real-time multiple pixel-registered images centered at different wavelengths in a single exposure, thereby providing overwhelming operational convenience. The results are advantageous for the development of a handheld narrowband multispectral imaging video camera for image guided medical surgery.
Relationship of cell death to cyclophosphamide‐induced ocular malformations (1991)

Abstract C57BL/6J mice were used to study the ocular teratogenic effects of cyclophosphamide administered to pregnant females on d 9 of pregnancy at a dose of 5 mg/kg body weight. Nile blue staining demonstrated increased cell death at the base of the optic stalk, in the optic vesicle, and in the perivesicular mesenchyme in treated embryos. Malformations studied at gestational d 11 and 16 by light and scanning electron microscopy included microphthalmos, microphakia, and aphakia and were predictable based upon patterns of increased cell death. These anomalies are similar to those reported with exposure to ethanol or isotretinoin on gestational d 7.
Pattern recognition in DNA sequences and its application to consensus foot-printing (1993)

We consider the problem of comparing several nucleic acid sequences to identify words occurring imperfectly (patterns with no gap) with unusual frequency. Methods for computing, representing, and inspecting interactively the structure of such repeating motifs in nucleic acids and more generally any text are described. Multiple sequences are treated as one large concatenate. In a preprocessing step, a lexical index is created to provide rapid string matching for the enumeration of the words matching a pattern. For given word features (word length, minimal frequency), a sequence profile is displayed. The profile can be inspected interactively with on-line algorithms. Applications to the identification of regulatory elements in DNA regions involved in the control of gene expression are presented. Our program ('DNA-Lexemics') runs on the Macintosh.
Molecular Determinants of the V3 Loop of Human Immunodeficiency Virus Type 1 Glycoprotein gp120 Responsible for Controlling Cell Tropism (1994)

We and others have identified the major determinant of cell tropism in human immunodeficiency virus type 1 (HIV-1) as the V3 loop of glycoprotein gp120. We have conducted a detailed study of two molecularly cloned isolates of HIV-1, HIVJR-CSF and HIVNL4-3, that differ in their tropism for immortalized CD4+ cell lines, by constructing a series of site-directed mutations within the V3 loop of HIVJR-CSF based on the sequence of HIVNL4-3. The phenotypes of these mutants fall into two classes, those which are viable and those which are not. A spontaneous mutant with significantly altered growth properties was also recovered and found to have an additional single amino acid change in the V3 loop sequence. The carboxy-terminal beta-strand part of the V3 loop is the major determinant of cell tropism. However, the results presented here indicate that the functional role of the V3 loop sequences can only be interpreted properly in the context of the original gp120 backbone from which they were derived. These findings show that over-simplistic interpretation of sequence data derived from unknown mixtures of HIV variants in infected persons may be highly misleading.
Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface (2002)

The authors concluded that curcumin contributed not only to the inhibition of IL-8 production but also to signal transduction through IL-8 receptors. These data suggest that curcumin reduces numerous IL-8 bioactivities that contribute to tumor growth and carcinoma cell viability. From this point of view, curcumin is a potent anticancer agent that inhibits the production of proinflammatory cytokines, including IL-8, by tumor cells.
10 Gbit/s×10-channel WDM transmission experiment over 1200 km with repeater spacing of 100 km without gain equalization or pre-emphasis (2005)

Summary form only given. We demonstrate 10-Gbit/s l0-channel transmission with 100-km dispersion-shifted fiber spacing by using spectrally flat gain erbium-doped fiber amplifiers (EDFAs). The EDFAs with high Al concentration were optimized with WDM transmission, and gain equalization and pre-emphasis were not required. We employed unequal channel spacing and dispersion compensation to suppress the effect of four-wave mixing (FWM) and XPM, respectively.