gebhart/patrepeval huggingface dataset:
Gap junction structures: Analysis of the x-ray diffraction data (1977)

Models for the spatial distribution of protein, lipid and water in gap junction structures have been constructed from the results of the analysis of X-ray diffraction data described here and the electron microscope and chemical data presented in the preceding paper (Caspar, D. L. D., D. A. Goodenough, L. Makowski, and W.C. Phillips. 1977. 74:605-628). The continuous intensity distribution on the meridian of the X-ray diffraction pattern was measured, and corrected for the effects of the partially ordered stacking and partial orientation of the junctions in the X-ray specimens. The electron density distribution in the direction perpendicular to the plane of the junction was calculated from the meridional intensity data. Determination of the interference function for the stacking of the junctions improved the accuracy of the electron density profile. The pair-correlation function, which provides information about the packing of junctions in the specimen, was calculated from the interference function. The intensities of the hexagonal lattice reflections on the equator of the X-ray pattern were used in coordination with the electron microscope data to calculate to the two-dimensional electron density projection onto the plane of the membrane. Differences in the structure of the connexons as seen in the meridional profile and equatorial projections were shown to be correlated to changes in lattice constant. The parts of the junction structure which are variable have been distinguished from the invariant parts by comparison of the X-ray data from different specimens. The combination of these results with electron microscope and chemical data provides low resolution three- dimensional representations of the structures of gap junctions.
APLP2 regulates the expression of MHC class I molecules on irradiated Ewing’s sarcoma cells (2013)

Ewing's sarcoma (EWS) is a pediatric cancer that is conventionally treated by surgery, chemotherapy, and radiation therapy. Innovative immunotherapies to treat EWS are currently under development. Unfortunately for EWS patients, when the disease is found to be resistant to current therapeutic approaches, the prognosis is predictably grim. Radiation therapy and immunotherapy could potentially synergize in the eradication of EWS, as some studies have previously shown that irradiation increases the presence of immune receptors, including MHC class I molecules, on the surface of tumor cells. However, EWS cells have been reported to express low levels of MHC class I molecules, a phenotype that would inhibit T-cell mediated lysis. We have previously demonstrated that the transgene-driven overexpression of amyloid β (A4) precursor-like protein 2 (APLP2) reduces the expression of MHC class I molecules on the surface of human cervical carcinoma HeLa cells. We thus examined whether endogenously expressed APLP2 downregulates MHC class I expression on EWS cells, particularly upon irradiation. We found that irradiation induces the relocalization of APLP2 and MHC class I molecules on the surface of EWS cells, redistributing cells from subpopulations with relatively low APLP2 and high MHC class I into subpopulations with relatively high APLP2 and low MHC class I surface expression. Consistent with these findings, the transfection of an APLP2-targeting siRNA into EWS cells increased MHC class I expression on the cell surface. Furthermore, APLP2 was found by co-immunoprecipitation to bind to MHC class I molecules. Taken together, these findings suggest that APLP2 inhibits MHC class I expression on the surface of irradiated EWS cells by a mechanism that involves APLP2/MHC class I interactions. Thus, therapeutic strategies that limit APLP2 expression may boost the ability of T cells to recognize and eradicate EWS in patients.
Ramage (1920)

Journal Article Ramage Get access M. Y. W. M. Y. W. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s12-VI, Issue 109, 15 May 1920, Page 207, https://doi.org/10.1093/nq/s12-VI.109.207a Published: 15 May 1920
Common channel interference cancellation for a spread spectrum system (2005)

This paper has mainly focussed on evaluating the potential performance improvements that accrue from cancelling the common pilot channel's interference in terms of bit error rate performance for downlink applications. The impact of different cancellation strategies - sequential (SIC) and parallel (PIC) - has been presented for various data rates and channel profiles. With the investigative analysis appertaining to the FDD element of the UTRAN specified by 3GPP, the performance of the interference cancellation unit is primarily based on the elimination of the cross-correlation of the spreading codes over time dispersive wireless conditions. With a sound channel estimate, the results are shown to achieve near interference free performance, highlighting the potentiality of these interference cancellation schemes. Their versatility and robustness against channel estimation errors is further demonstrated by a relative performance comparison for a diversified range of data rates, pilot-to-data power ratios and channel conditions.
Broadband ISDN resource management: the role of virtual paths (1991)

It is shown that virtual paths will be a substantial component of a resource management control hierarchy for the B-ISDN. Other components of this hierarchy include connection admission, usage parameter control, and reactive congestion control. An overview of this control hierarchy is provided. The role of virtual paths for cost-effective resource management and connection admission control in the B-ISDN is examined. Some strategies for reserving capacity on virtual paths are identified, and the use of virtual paths to simplify connection admission control is discussed. The reservation of capacity on virtual path connections is shown to result in substantial network cost savings for the case study considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Iterated Multi-Robot Auctions for Precedence-Constrained Task Scheduling (2016)

We consider the multi-robot task scheduling problem with precedence constraints, and introduce a general algorithm to approximate a solution to this problem. Our algorithm utilizes an iterated auction scheme, in which a batch of tasks that are pairwise unconstrained is selected in each iteration and scheduled using a modified sequential single-item auction. This algorithm also gains flexibility by allowing the use of task prioritization to order the scheduling process. We demonstrate the effectiveness of this iterated auction scheme empirically using existing 100- and 1000-task data sets that we have modified to include precedence constraints.
Fast geometric point labeling using conditional random fields (2009)

In this paper we present a new approach for labeling 3D points with different geometric surface primitives using a novel feature descriptor - the Fast Point Feature Histograms, and discriminative graphical models. To build informative and robust 3D feature point representations, our descriptors encode the underlying surface geometry around a point p using multi-value histograms. This highly dimensional feature space copes well with noisy sensor data and is not dependent on pose or sampling density. By defining classes of 3D geometric surfaces and making use of contextual information using Conditional Random Fields (CRFs), our system is able to successfully segment and label 3D point clouds, based on the type of surfaces the points are lying on. We validate and demonstrate the method's efficiency by comparing it against similar initiatives as well as present results for table setting datasets acquired in indoor environments.
Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes (1997)

In order to elucidate the influence of dietary constituents on colonic intracellular signal transduction, the effect of different fats on rat colonic epithelial protein kinase C (PKC) alpha (classical), delta (novel) and lambda-zeta (atypical) expression was determined in carcinogen-treated animals. Sprague-Dawley rats were provided with one of two fats (corn oil and fish oil); plus or minus the carcinogen azoxymethane (AOM) and killed at two time points (15 and 37 weeks) in a 2x2x2 factorial design. At 5 and 6 weeks of age, animals were injected s.c. with either AOM at a dose of 15 mg/kg body weight or saline once a week for 2 weeks and continued on the same diet until termination of the study. At 15 and 37 weeks after the second injection, 10 rats from each treatment group were killed. Colonic PKC alpha, delta and lambda-zeta steady-state protein and mRNA levels were determined using immunoblotting and relative quantitative polymerase chain reaction, respectively. Colonic mucosa from rats injected with AOM had significantly suppressed membrane and cytosolic PKC alpha and cytosolic lambda-zeta protein levels (P < 0.05) as compared to saline-injected control animals at both time points. In contrast, rats fed fish oil diets had significantly higher (P < 0.05) cytosolic PKC delta and lambda-zeta protein levels relative to animals fed corn oil diets. However, the effect of diet and AOM on the steady-state expression of PKC alpha, delta and zeta mRNA was not consistent with changes in the respective isozyme protein levels, suggesting regulation at the post-transcriptional level. These data demonstrate that dietary fish oil blocks the carcinogen-induced decrease in the steady-state levels of colonic mucosal PKC delta and lambda-zeta, which may in part explain why this fat source protects against colon cancer development.
Nurses in OR are more assertive than radiographers. (1994)

This study investigated two hypotheses: that there is a positive correlation between assertiveness and self-esteem, and that nurses rate lower than non-nurses on the constructs. A self-report survey incorporating scales for general assertiveness, situationally-specific assertiveness, global self-esteem and differentiated self-esteem was utilised. For the sample of 83 operating room nurses and 81 radiographers, correlations significant at the p < .001 level between the respective scales supported the first hypothesis. Analysis of variance yielded no significant differences between the two groups on either self-esteem measures or general assertiveness, with the nurses scoring significantly higher than radiographers on the situationally-specific assertiveness scale. Findings challenge the stereotype of the 'shrinking violet' nurse. Additional analysis revealed that the power component of differentiated self-esteem had a higher correlation with global self-esteem and with both assertiveness measures than any other component. Further, the operating room nurses were significantly more power-oriented than radiographers. The pre-eminence of power in the findings suggests that assertiveness and self-esteem are issues relating to the empowerment of nurses.
Differential effects of intravenous R,S‐(±)‐3,4‐methylenedioxymethamphetamine (MDMA, Ecstasy) and its S(+)‐ and R(−)‐enantiomers on dopamine transmission and extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus accumbens shell and core (2007)

R,S(+/-)-3,4-methylenedioxymethamphetamine (R,S(+/-)-MDMA, 'Ecstasy') is known to stimulate dopamine (DA) transmission in the nucleus accumbens (NAc). In order to investigate the post-synaptic correlates of pre-synaptic changes in DA transmission and their relationship with MDMA enantiomers, we studied the effects of R,S(+/-)-MDMA, S(+)-MDMA, and R(-)-MDMA on extracellular DA and phosphorylated extracellular signal regulated kinase (pERK) in the NAc shell and core. Male Sprague-Dawley rats, implanted with a catheter in the femoral vein and vertical concentric dialysis probes in the NAc shell and core, were administered i.v. saline, R,S(+/-)-MDMA, S(+)-MDMA, or R(-)-MDMA. Extracellular DA was monitored by in vivo microdialysis with HPLC. Intravenous R,S(+/-)-MDMA (0.64, 1, and 2 mg/kg) increased dialysate DA, preferentially in the shell, in a dose-related manner. S(+)-MDMA exerted similar effects but at lower doses than R,S(+/-)-MDMA, while R(-)-MDMA (1 and 2 mg/kg) failed to affect dialysate DA. R,S(+/-)- and S(+)-MDMA but not R(-)-MDMA increased ERK phosphorylation (expressed as density/neuron and number of pERK-positive neurons/area) in both subdivisions of the NAc. The administration of the D1 receptor antagonist, SCH 39166, prevented the increase in pERK elicited by R,S(+/-)-MDMA and S(+)-MDMA, while the D2/3 receptor antagonist, raclopride, increased pERK in the NAc core per se but failed to affect the R,S(+/-)-MDMA-elicited stimulation of pERK. The present results provide evidence that the DA stimulant effects of racemic MDMA are accounted for by the S(+)-enantiomer and that pERK may represent a post-synaptic correlate of the stimulant effect of R,S(+/-)-MDMA on D1-dependent DA transmission.
A mammalian ortholog of <i>Drosophila timeless</i>, highly expressed in SCN and retina, forms a complex with mPER1 (1999)

We have reported the isolation of the mouse timeless cDNA, the expression of the mTim mRNA and an interaction of mTIM with mPER1. These results indicate that the autoregulatory feedback mechanism of circadian oscillation of the period gene may also be conserved in mammals.
RBF-Based QP Estimation Model for VBR Control in H.264/SVC (2011)

In this paper, we propose a novel variable bit rate (VBR) controller for real-time H.264/scalable video coding (SVC) applications. The proposed VBR controller relies on the fact that consecutive pictures within the same scene often exhibit similar degrees of complexity, and consequently should be encoded using similar quantization parameter (QP) values for the sake of quality consistency. In order to prevent unnecessary QP fluctuations, the proposed VBR controller allows for just an incremental variation of QP with respect to that of the previous picture, focusing on the design of an effective method for estimating this QP variation. The implementation in H.264/SVC requires to locate a rate controller at each dependency layer (spatial or coarse grain scalability). In particular, the QP increment estimation at each layer is computed by means of a radial basis function (RBF) network that is specially designed for this purpose. Furthermore, the RBF network design process was conceived to provide an effective solution for a wide range of practical real-time VBR applications for scalable video content delivery. In order to assess the proposed VBR controller, two real-time application scenarios were simulated: mobile live streaming and Internet protocol television broadcast. It was compared to constant QP encoding and a recently proposed constant bit rate (CBR) controller for H.264/SVC. The experimental results show that the proposed method achieves remarkably consistent quality, outperforming the reference CBR controller in the two scenarios for all the spatio-temporal resolutions considered.
Verified hybrid controllers for automated vehicles (1998)

The objective of an automated highway system (AHS) is to increase the safety and throughput of the existing highway infrastructure by introducing traffic automation. AHS is an example of a large scale, multiagent complex dynamical system and is ideally suited for a hierarchical hybrid controller. We discuss the design of safe and efficient hybrid controllers for regulation of vehicles on an AHS. We use game theoretic techniques to deal with the multiagent and multiobjective nature of the problem. The result is a hybrid controller that by design guarantees safety, without the need for further verification. The calculations also provide an upper bound on the performance that can be expected in terms of throughput at various levels of centralization.
Nanofilm Biomaterials: Localized Cross-Linking To Optimize Mechanical Rigidity and Bioactivity (2010)

Nanofilm biomaterials, formed by the layer-by-layer assembly of charged macromolecules, are important systems for a variety of cell-contacting biomedical and biotechnological applications. Mechanical rigidity and bioactivity are two key film properties influencing the behavior of contacting cells. Increased rigidity tends to improve cells attachment, and films may be rendered bioactive through the incorporation of proteins, peptides, or drugs. A key challenge is to realize films that are simultaneously rigid and bioactive. Chemical cross-linking of the polymer framework--the standard means of increasing a film's rigidity--can diminish bioactivity through deactivation or isolation of embedded biomolecules or inhibition of film biodegradation. We present here a strategy to decouple mechanical rigidity and bioactivity, potentially enabling nanofilm biomaterials that are both mechanically rigid and bioactive. Our idea is to selectively cross-link the outer region of the film, resulting in a rigid outer skin to promote cell attachment, while leaving the film interior (with any embedded bioactive species) unaffected. We propose an approach whereby an N-hydroxysulfosuccinimide (sulfo-NHS) activated poly(L-glutamic acid) is added as the terminal layer of a multilayer film and forms (covalent) amide bonds with amino groups of poly(L-lysine) placed previously within the film. We characterize film assembly and cross-linking extent via quartz crystal microbalance with dissipation monitoring (QCMD), Fourier transform infrared spectroscopy in attenuated total reflection mode (FTIR-ATR), and laser scanning confocal microscopy (LSCM) and measure the attachment and metabolic activity of preosteoblastic MC3T3-E1 cells. We show cross-linking to occur primarily at the film surface and the subsequent cell attachment and metabolic activity to be enhanced compared to native films. Our method appears promising as a means to realize films that are simultaneously mechanically rigid and bioactive.
Effect of maternal nicotine exposure on neonatal lung elastic tissue and possible consequences. (1992)

The effect of maternal nicotine exposure (1 mg/kg body mass/d) on the lung elastic tissue of 1-day-old rat pups was investigated. The results show that maternal nicotine exposure resulted in a very low elastic tissue content in the lungs of these rat pups compared with those of the controls. This may interfere with normal lung development since elastic tissue is part of the lung connective tissue structure and is involved in the formation of alveoli. Impaired elastic synthesis may thus make the rat pups more susceptible to lung diseases such as emphysema.
Rejoining and Misrejoining of Radiation-Induced Chromatin Breaks. I. Experiments with Human Lymphocytes (1996)

Fluorescence in situ hybridization with a composite probe for human chromosome 4 and a probe that stained all centromeres was used to study gamma-ray induced breakage, rejoining and misrejoining in prematurely condensed chromosomes in human lymphocytes. Dose-response curves for the induction of all types of aberrations in prematurely condensed human chromosomes 4 were determined immediately after irradiation and after 8 h postirradiation incubation. In addition, aberrations were measured after various incubation times from 0 to 18 h after a dose of 7 Gy. Unrejoined chromosome breaks were the most frequent type of aberration observed immediately after irradiation. Approximately 15% of total aberrations observed were chromosome exchanges. After 8 h postirradiation incubation, the frequency of breaks in prematurely condensed chromosomes declined to about 20% of the initial value, and chromosomal exchanges became the most frequent aberration. Results of metaphase analysis were similar to those for prematurely condensed chromosomes after 8 h incubation with the exception that a significantly lower frequency of fragments was observed. Symmetrical and asymmetrical interchanges were found at similar frequencies at all doses. No complex exchanges were observed in lymphocyte chromosomes immediately after exposure. They accounted for about 1% of total exchanges in metaphase chromosomes at doses <3 Gy and about 14% at 7 Gy. Incomplete exchanges amounted to approximately 15% of total exchanges at all doses. The kinetics of break rejoining was exponential, and the frequency of exchanges increased with kinetics similar to that observed for the rejoining of the breaks. This increase in the total exchanges as a function of the time between irradiation and fusion was due to a rapid increase in reciprocal interchanges, and a slower increase in complex exchanges; the frequency of incomplete exchanges increased initially, then decreased with prolonged incubation to the level observed in metaphase. It is concluded that the formation of each kind of chromosome aberrations follows different kinetics.
Stochastic Modeling of Combined Sewer Flows (1991)

Modeling of sewer flow and quality is essential for real-time control (RTC) of sewer system and minimization of combined sewer overflows (CSOs). In this paper, the Box-Jenkins type transfer function is applied to the daily rainfall and sewer flow data to incorporate the stochastic nature of the rainfall and flow series. Two system identification techniques, different from the traditional Box-Jenkins', approach, are developed to identify sewer flow models. Both techniques are illustrated through their application of modeling sewer flow with actual time series of flow and rainfall from a combined sewer system. The onestep ahead predicted flow values are found to be in good agreement with the measured values.
La fin des paroisses (1997)

Lieu de reference, place eminente de reunion des chretiens, la paroisse fait partie a la fois des lieux de vie et de memoire que chacun connait sans toujours pouvoir en dessiner les frontieres. Structure fondamentale et territoriale du peuplement, traduite en diverses institutions civiles au cours des deux derniers siecles, la paroisse a ete le cadre et l'institution de base de la vie sociale des communautes. Dans cet ouvrage original, resultant d'une recherche menee collectivement depuis quatre ans par un groupe de geographes qui s'interrogent tout particulierement sur les liens entre l'espace et la spiritualite, sont etudies la vie et la survie des formes de remplacement de la paroisse.
Impact factors of psychiatric journals (1997)

The BJP would have to change the nature and number of papers published to improve its impact factor. There are a number of limitations to citation data and such data are only one of several factors useful in evaluating the importance of a journal's contribution to scientific and clinical communities.
Automatic parallelization of recursive procedures (1999)

Parallelizing compilers have traditionally focussed mainly on parallelizing loops. This paper presents a new framework for automatically parallelizing recursive procedures that typically appear in divide-and-conquer algorithms. We present compile-time analysis to detect the independence of multiple recursive calls in a procedure. This allows exploitation of a scalable form of nested parallelism, where each parallel task can further spawn off parallel work in subsequent recursive calls.We describe a run-time system which efficiently supports this kind of nested parallelism without unnecessarily blocking tasks. We have implemented this framework in a parallelizing compiler, which is able to automatically parallelize programs like quicksort and mergesort, written in C.For cases where even the advanced symbolic analysis and array section analysis we describe are not able to prove the independence of procedure calls, we propose novel techniques for speculative run-time parallelization, which are more efficient and powerful in this context than analogous techniques proposed previously for speculatively parallelizing loops. Our experimental results on an IBM G30 SMP machine show good speedups obtained by following our approach.