gebhart/patrepeval huggingface dataset:
Self-Neglect: A Proposed New NANDA Diagnosis (2006)

The proposed diagnosis, self-neglect, fills a gap in current standardized terminology. This diagnosis will contribute significantly to nurses leading the way in the explication of an interdisciplinary and international health concern. PRACTICE AND POLICY IMPLICATIONS: Developing self-neglect as a recognized nursing label is vital to clinicians and policy makers within and across countries. Appreciating less serious/non-life-threatening presentations will give nurses a care perspective to improve the health and well-being of those in earlier stages of self-neglect. Definitions for this phenomenon will contribute to care planning and interventions, leading to consistency in practice and research.
Dynamic Regulation of Effector Protein Binding to Histone Modifications: The Biology of HP1 Switching (2006)

Post-translational modifications of histone proteins, the basic building blocks around which eukaryotic DNA is organized, are crucially involved in the regulation of genome activity as they control chromatin structure and dynamics. The recruitment of specific binding proteins that recognize and interact with particular histone modifications is thought to constitute a fundamental mechanism by which histone marks mediate biological function. For instance, tri-methylation of histone H3 lysine 9 (H3K9me3) is important for recruiting heterochromatin protein 1 (HP1) to discrete regions of the genome, thereby regulating gene expression, chromatin packaging, and heterochromatin formation. Until now, little was known about the regulation of effector-histone mark interactions, and in particular, of the binding of HP1 to H3K9me3. Recently, we and others presented evidence that a "binary methylation-phosphorylation switch" mechanism controls the dynamic release of HP1 from H3K9me3 during the cell cycle: phosphorylation of histone H3 serine 10 (H3S10ph) occurs at the onset of mitosis, interferes with HP1-H3K9me3 interaction, and therefore, ejects HP1 from its binding site. Here, we discuss the biological function of HP1 release from chromatin during mitosis, consider implications why the cell controls HP1 binding by such a methylation-phosphorylation switching mechanism, and reflect on other cellular pathways where binary switching of HP1 might occur.
HandiMate (2015)

Building from our previous work we explore HandiMate, a robotics kit which enables users to construct and animate their toys using everyday craft materials [32]. The kit contains eight joint modules, a tablet interface and a glove controller. Unlike popular kits, HandiMate does not rely on manufactured parts to construct the toy. Rather this open ended platform engages users to pursue interest driven activities using everyday objects, such as cardboard, construction paper, and spoons. These crafted parts are then fastened together using Velcro to the joint modules and animated using the glove as the controller. In this paper, we discuss the results from two user studies which were designed to understand the affinity of HandiMate among children. The first study reveals that children rated the HandiMate kit as gender-neutral, appealing equally to both female and male students. The second study discusses the benefits of engaging children in engineering design with HandiMate, which has been observed to bring out children's tacit physics-based engineering knowledge and facilitate learning.
Knowledge management: problems, promises, realities, and challenges (2001)

This article explores the implications of a design perspective for knowledge management (KM). We examine the major problems which our approach must address, the promises it offers, the realities we have explored in our work and the continuing challenges. The authors' KM approach assumes that knowledge is not a commodity but that it is collaboratively designed and constructed.
Concepts for smart AD and DA converters (2010)

This thesis studies the `smart' concept for application to analog-to-digital and digital-to-analog converters. The smart concept aims at improving performance - in a wide sense - of AD/DA converters by adding on-chip intelligence to extract imperfections and to correct for them. As the smart concept can correct for certain imperfections, it can also enable the use of more efficient architectures, thus yielding an additional performance boost. Chapter 2 studies trends and expectations in converter design with respect to applications, circuit design and technology evolution. Problems and opportunities are identfied, and an overview of performance criteria is given. Chapter 3 introduces the smart concept that takes advantage of the expected opportunities (described in chapter 2) in order to solve the anticipated problems. Chapter 4 applies the smart concept to digital-to-analog converters. In the discussed example, the concept is applied to reduce the area of the analog core of a current-steering DAC. It is shown that a sub-binary variable-radix approach reduces the area of the current-source elements substantially (10x compared to state-of-the-art), while maintaining accuracy by a self-measurement and digital pre-correction scheme. Chapter 5 describes the chip implementation of the sub-binary variable-radix DAC and discusses the experimental results. The results confirm that the sub-binary variable-radix design can achieve the smallest published current-source-array area for the given accuracy (12bit). Chapter 6 applies the smart concept to analog-to-digital converters, with as main goal the improvement of the overall performance in terms of a widely used figure-of-merit. Open-loop circuitry and time interleaving are shown to be key to achieve high-speed low-power solutions. It is suggested to apply a smart approach to reduce the effect of the imperfections, unintentionally caused by these key factors. On high-level, a global picture of the smart solution is proposed that can solve the problems while still maintaining power-efficiency. Chapter 7 deals with the design of a 500MSps open-loop track-and-hold circuit. This circuit is used as a test case to demonstrate the proposed smart approaches. Experimental results are presented and compared against prior art. Though there are several limitations in the design and the measurement setup, the measured performance is comparable to existing state-of-the-art. Chapter 8 introduces the first calibration method that counteracts the accuracy issues of the open-loop track-and-hold. A description of the method is given, and the implementation of the detection algorithm and correction circuitry is discussed. The chapter concludes with experimental measurement results. Chapter 9 introduces the second calibration method that targets the accuracy issues of time-interleaved circuits, in this case a 2-channel version of the implemented track-and-hold. The detection method, processing algorithm and correction circuitry are analyzed and their implementation is explained. Experimental results verify the usefulness of the method.
AMPA Receptor Trafficking and Synaptic Plasticity (2002)

Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.
The Tomato Mosaic Tobamovirus Movement Protein Interacts with a Putative Transcriptional Coactivator KELP (2001)

Viral movement through plasmodesmata in host plants likely depends on the interaction between virus-encoded movement protein (MP) and host proteins. In order to search for MP-interacting protein (MIP), we carried out far-western screening of a Brassica campestris cDNA library using a recombinant MP of tomato mosaic tobamovirus (ToMV) as a probe. One of the positive clones, designated MIP102, was found to be a putative orthologue for a transcriptional coactivator KELP of Arabidopsis thaliana. In vitro analysis with recombinant proteins revealed that ToMV MP could bind to KELP proteins that are derived from different plant species. At least 31 amino acids from the carboxyl-terminus of ToMV MP were dispensable for the interaction with KELP. Other MPs, derived from crucifer tobamovirus CTMV-W and cucumber mosaic cucumovirus, also exhibited comparable binding abilities. This suggests that these MPs could commonly interact with KELP, possibly to modulate the host gene expression.
PREPARATION OF 1,7-DISUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINES (2002)

ABSTRACT A simple procedure for the preparation of 1,7-disubstituted-1,2,3,4-tetrahydroisoquinolines from 3,4-dihydroisoquinoline (2) is presented. This strategy overcomes the limitation of cyclisation approaches which generally require electron rich ring systems. A variety of 1-substituents has been incorporated using the appropriate organometallic or activated methylene nucleophile to prepare both electron rich (7a–f) and electron deficient 1,7-disubstituted-1,2,3,4-tetrahydroisoquinolines (16, 17).
Malaria related to constructions in Panaji, Goa. (1991)

A marked difference in malaria incidence amongst labour imported for construction and local residents was observed in a study following the outbreak of malaria in Panaji (Goa) in 1986. Water stagnation in and around the construction was the main breeding site for An. stephensi and the intensity of malaria transmission was dependent on the area under construction.
Observations of forests using a helicopter-borne nadir-looking radar: a new method for morphometric purposes (1999)

The authors present an original pattern recognition method for the observation of forests using a nadir-looking ranging scatterometer. The radar configuration provides vertical profiles of the vegetation. Radar data were not processed in a classical way, i.e., the calculation of a radar cross section, but through pattern recognition methods applied to the raw data. The aim of the study was to search for typical patterns related to three types of forests. A small subsample of the data was determined for methodology validation purposes. Some results are also reported for a much larger data set. Morphodecomposition, a new methodology presented for the first time in these types of applications, is able to recognize the main features of the data, not only the types of forests involved, but also subtle morphological patterns of the signals. Morphodecomposition provides a morphometric methodology applicable to other geophysical univariate sampled signals.
Temporal Stability of Epigenetic Markers: Sequence Characteristics and Predictors of Short-Term DNA Methylation Variations (2012)

The degree of short-term DNA methylation stability is marker-dependent and associated with sequence characteristics and methylation levels.
Selective Synthesis of 6-Ribo- (and Xylo) Pyrano and Furano Aminopyrimidines<sup>1</sup>. Anticancer and Anti-AIDS Activities (1994)

Abstract The synthesis and the anticancer and anti-AIDS activity of some 6-ribo (and xylo) pyrano and furano aminopyrimidines have been carried out. Isomerization to ribopyranose has been observed when per-O-acyl ribofuranoses were deprotected under basic medium.
Using a single address space operating system for distributed computing and high performance (1999)

Recent 64-bit microprocessors have made a huge 18.4 quintillion byte address space potentially available to programs. This has led to the design of Operating Systems that provide a single virtual address space in which all code and data reside in and that spans all levels of storage and all nodes of a distributed system. These operating systems called SASOSs, have characteristics that can be used to support synchronization and coherency in a distributed system in ways that provide an improved program development environment and higher performance than that available from conventional operating systems. Sombrero, our SASOS design, makes use of its hardware support for object-grained protection, separate thread related protection domains and implicit protection domain crossing to provide synchronization and coherency support for distributed object copy set management not available in SASOSs built on stock processors. Its design, which provides direct system level support for object oriented programming includes a number of system architectural features targeted at modern distributed computing.
Natural convection between heated vertical plates in a horizontal magnetic field (1961)

The effect of viscous dissipation and applied magnetic field is investigated for the case of the fully developed natural convection of a fluid between two heated walls. When electrical and viscous dissipation is negligible, short-circuited Hartmann flow results. The deviation of the velocity and temperature profiles from those existing in Hartmann flow are presented for various Hartmann numbers when dissipation is not neglected. It is shown that increasing the applied magnetic field rapidly decreases the influence of both viscous and joulean dissipation on the velocity and temperature profiles.
ANGIOTENSIN-CONVERTING ENZYME INHIBITOR CAPTOPRIL PREVENTS OLEIC ACID-INDUCED SEVERE ACUTE LUNG INJURY IN RATS (2007)

Lack of specific and efficient therapy leads to the high mortality rate of acute lung injury (ALI) and acute respiratory distress (ARDS). Recent evidence implies that angiotensin-converting enzyme (ACE) plays an important role in the pathogenesis of ALI. Pharmaceutical inhibitors of ACE have been used clinically for hypertension but not for ALI/ARDS yet. The objective was to study the effects of ACE inhibition with captopril on severe lung injury induced by oleic acid (OA) in rats. Oleic acid was intravenously injected into Sprague Dawley rats, followed by i.p. administration of captopril or saline control. Lung injury, endothelium damage and related molecules, and disturbance of coagulation were examined in comparison between the treated and the nontreated groups. An OA-induced ALI was featured with thickening of the alveolar septa, alveolar hemorrhage, and infiltration of inflammatory cells. Comparing with the nontreated OA group, the administration of captopril prevented the rats from OA-induced severe lungs injury, with a significantly lower lung injury score, less albumin content and infiltrated cells in the alveoli, decreased wet/dry weight ratio of the lung tissues, and improved lung function (PaO2 per fraction of inspired oxygen). Captopril also dramatically reduced the expression of intercellular adhesion molecule-1 in the lung tissue and in the circulating endothelial cells in the blood, indicating a protective effect on endothelial cells activation/damage. Moreover, captopril treatment led to a blockage of nuclear factor kappaB activation in lung tissues and to the recovery of the fibrinolytic disturbance. Thus, our data suggest that the inhibition of ACE with its clinically used inhibitor offers protective effects on ALI/ARDS, implying the potential for therapeutic option.
Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing (2012)

BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in tissue repair and tumorigenesis. EPCs migrate from BM to tissues via the bloodstream, but specific chemotactic cues have not been identified. Here we show in mice that the absence of CCR5 reduced vascular EPC accumulation and neovascularization, but not macrophage recruitment, and eventually delayed healing in wounded skin. When transferred into Ccr5-/- mice, Ccr5+/+ BM cells, but not Ccr5-/- cells, accumulated in the wound site, were incorporated into the vasculature, and restored normal neovascularization. Consistent with these observations, CCL5 induced in vitro EPC migration in a CCR5-dependent manner. Moreover, expression of VEGF and TGF-β was substantially diminished at wound sites in Ccr5-/- mice, which suggests that EPCs are important not only as the progenitors of endothelial cells, but also as the source of growth factors during tissue repair. Taken together, these data identify the CCL5/CCR5 interaction as what we believe to be a novel molecular target for modulation of neovascularization and eventual tissue repair.
Impact of surface nanostructure on ice nucleation (2014)

Nucleation of water on solid surface can be promoted noticeably when the lattice parameter of a surface matches well with the ice structure. However, the characteristic length of the surface lattice reported is generally less than 0.5 nm and is hardly tunable. In this paper, we show that a surface with nanoscale roughness can also remarkably promote ice nucleation if the characteristic length of the surface structure matches well with the ice crystal. A series of surfaces composed of periodic grooves with same depth but different widths are constructed in molecular dynamics simulations. Water cylinders are placed on the constructed surfaces and frozen at constant undercooling. The nucleation rates of the water cylinders are calculated in the simulation using the mean first-passage time method and then used to measure the nucleation promotion ability of the surfaces. Results suggest that the nucleation behavior of the supercooled water is significantly sensitive to the width of the groove. When the width of the groove matches well with the specific lengths of the ice crystal structure, the nucleation can be promoted remarkably. If the width does not match with the ice crystal, this kind of promotion disappears and the nucleation rate is even smaller than that on the smooth surface. Simulations also indicate that even when water molecules are adsorbed onto the surface structure in high-humidity environment, the solid surface can provide promising anti-icing ability as long as the characteristic length of the surface structure is carefully designed to avoid geometric match.
The Moderating Role of Intercultural Service Encounters in the Relationship among Tourist’s Destination Image, Perceived Value and Environmentally Responsible Behaviors (2018)

Because of the popularity of tourism worldwide, each tourist destination has received more and more international tourists. The increasing tourism activities may result in the change of the environment and ecosystem of the destinations. The environmental destruction caused by the tourists has received attention from all sectors of the community. Studies have shown that destination image is one of the key factors attracting tourists and affecting their behaviors during their trips. The cross-cultural interaction between international tourists and locals, with the increasing amount of international travelers, is also intensified and receiving academic attention. Nevertheless, no research has studied the influence of the cross-cultural interaction in hospitality in the hospitality sectors in tourist’s Environmentally responsible behavior. The purpose of this study was to investigate the relationship among the international tourists’ destination images, perceived value and environmentally responsible behavior in Macau. The role of intercultural service encounter during tourists’ visit in the city related to their destination image and perceived value were also examined. Results showed that international tourists’ image of destination were significantly related to their perceived values, as the perceived values was found to play as a mediator between their image of the city and their environmentally responsible behavior. The results also revealed that the international tourists’ experience of service encounters had moderating effect between their destination image and perceived value of the trip. While at the same level of destination image, the tourists who had good experience during their encounters with local service sectors had better perceived value of their trip. Besides, when the international tourists who had higher perception of service encounters, the increase of the tourists’ image of destination could much better enhanced their environmentally responsible behavior, as compared with the ones with lower perception of service encounters. Managerial implications to the local service sectors and authorities are also suggested.
Attenuation of ultrasound: magnitude and frequency dependence for tissue characterization. (1984)

Backscattered ultrasonic waveforms from selected regions of the liver were collected from B-scans of 11 male patients ranging from 13 to 41 years of age and analyzed to determine local values of both the magnitude and frequency dependence of attenuation. Processing was based on frequency domain analysis and also incorporated precise corrections for time-varying gain, nonlinear amplifier compression, and beam diffraction, which would otherwise degrade accuracy. The results demonstrate that (a) consistent and reproducible measurements of attenuation from one scan to the next are possible within a given patient, and (b) frequency dependence can deviate significantly from the linear relationship between frequency and attenuation commonly assumed for soft tissue. Based on the accuracy of the overall analysis and the reproducibility of the results, the authors suggest that a multivariate approach to clinical tissue characterization using both the magnitude and frequency dependence of ultrasonic attenuation may be possible.
Autoimmunity and pulmonary hypertension: a perspective (2005)

The association between autoimmunity and pulmonary arterial hypertension (PAH) has been appreciated for >40 yrs, but how autoimmune injury might contribute to the pathogenesis of this disease has only been examined in a case-specific manner. It is becoming increasingly clear that a variety of diverse clinical diseases, ranging from viral infections to connective tissue disorders, can culminate in pulmonary vascular pathology that is indistinguishable. Is there a hitherto unappreciated biology that unites these seemingly unrelated conditions? The answer to this question may come from the increasing body of evidence concerned with the central importance of regulatory T-cells in preventing inappropriate B-cell activity. Two striking similarities between conditions associated with severe angioproliferative pulmonary hypertension are a defect in the CD4 T-cell compartment and auto-antibody production. Pathogenic auto-antibodies targeting endothelial cells are capable of inducing vascular endothelial apoptosis and may initiate the development of PAH. The present review will focus on what is known about autoimmune phenomena in pulmonary arterial hypertension patients, in order to better consider whether an early loss of self-tolerance followed by autoimmune injury could influence the early development of severe angioproliferative pulmonary hypertension.
Towards interactive text understanding (2003)

This position paper argues for an interactive approach to text understanding. The proposed model extends an existing semantics-based text authoring system by using the input text as a source of information to assist the user in re-authoring its content. The approach permits a reliable deep semantic analysis by combining automatic information extraction with a minimal amount of human intervention.