gebhart/patrepeval huggingface dataset:
<b>Basic Concepts in Cellular Cardiac Electrophysiology:</b> Part II: Block of Ion Channels by Antiarrhythmic Drugs (1995)

Antiarrhythmic drugs have relative specificity for blocking each of the major classes of ion channels that control the action potential. The kinetics of block is determined by the state of the channel. Those channel states occupied at depolarized potentials generally have greater affinity for the blocking drugs. The kinetics of the drug-channel interaction is important in determining the blocking profile observed clinically. The increased mortality resulting from drug treatment in CAST and several atrial fibrillation trials has resulted in a shift in antiarrhythmic drug development from the Na+ channel blocking (Class I) drugs to the K+ channel blocking (Class III) drugs. While both Classes of drugs have a proarrhythmic potential, this may be less for the Class III agents. Their lack of negative inotropy also make them more attractive. It is important that the potential advantages of these agents be evaluated in controlled clinical trials. In several laboratories, the techniques of molecular biology and biophysics are being combined to determine the block site of available drugs. This information will aid in the future development of agents with greater specificity, and hopefully greater efficacy and safety than those currently in clinical use.
Gate Recessed Quasi-Normally OFF Al<sub>2</sub>O<sub>3</sub>/AlGaN/GaN MIS-HEMT With Low Threshold Voltage Hysteresis Using PEALD AlN Interfacial Passivation Layer (2014)

In this letter, a gate recessed normally OFF AlGaN/GaN MIS-HEMT with low threshold voltage hysteresis using Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /AlN stack gate insulator is presented. The trapping effect of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> /GaN interface was effectively reduced with the insertion of 2-nm AlN thin interfacial passivation layer grown by plasma enhanced atomic layer deposition. The device exhibits a threshold voltage of +1.5 V, with current density of 420 mA/mm, an OFF-state breakdown voltage of 600 V, and high ON/OFF drain current ratio of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> .
Optimizing conditions for growth and sporulation of <i>Pyrenophora semeniperda</i> (2003)

The effects of photoperiod, light quality, wounding and sealing of culture plates on in vitro growth and sporulation of Pyrenophora semeniperda were examined to define conditions conducive to the abundant and rapid production of conidia. For maximum growth and sporulation, the leaf‐spotting and seedborne plant pathogen required an alternating light/dark sequence. Fewer conidia were produced under conditions of constant illumination or constant darkness. Growth was enhanced by light of wavelengths longer than 500 nm, while sporulation was enhanced by light of wavelengths shorter than 500 nm. Sporulation was enhanced under conditions of alternating temperature with a diurnal photoperiod and by mycelial wounding. Sealing of Petri plates had an inhibitory effect on sporulation. Significantly more conidia of higher quality formed when unsealed cultures, wounded after 7 days, were exposed to 23°C during the light phase and 19°C during darkness. Under these optimal conditions, conidial numbers were increased by 800% or more compared with unwounded cultures grown at constant 25°C in 12 h alternating cool‐white light.
FURTHER EXPERIMENTS ON THE ACCOMMODATION CONVERGENCE RELATIONSHIP (1939)

Columbus, Ohio *An abridgment of the material presented before the American Academy of Optometry at Richmond, Va., June 23, 1938.
Implementation of Method for Operating Multiple High Frequency Surface Wave Radars on a Common Carrier Frequency (2006)

The increasing use of high frequency surface wave radar (HFSWR) for the surveillance of coastal regions is faced with the problem of limited channel availability in the electromagnetic spectrum. Thus there is a need for multiple radars to share a common frequency channel. Proof-of-concept work is presented here for a method to operate multiple radar systems on a common carrier frequency. A review is provided of an existing concept where a common waveform is modulated by tones varying by a few hertz across the different radars. The signals from the different radars are separated by either pulse-domain filtering or Doppler processing. An experiment has been performed that demonstrates the feasibility of the method. Limitations of the method are considered in terms of the linearity of the propagation channel.
More rapid progression to AIDS in older HIV-infected people: the role of CD4+ T-cell counts. (1991)

The tendency for older people with HIV infection to progress more rapidly to AIDS than younger people was studied in a group of 111 anti-HIV-positive haemophiliacs followed for up to 10 years from seroconversion. After 7 years of seropositivity, those aged over 30 years at the time of the first positive anti-HIV test had a cumulative progression rate to AIDS of 50%, compared with only 12% for those aged 10-19 years (Kaplan-Meier estimates). Overall, the relative risk of developing AIDS by any given time after seroconversion was 1.45 for each 10 year increase in age (p = 0.002; 95% confidence limits of 1.15, 1.85; Cox proportional hazards model). After adjustment for the CD4+ T-cell count (median of 10 count measurements per patient, fitted as a time-dependent covariate), the relative risk fell to 1.31 but remained statistically significant (p less than 0.05; 95% confidence limits of 1.03, 1.67). This implies that older people may be at higher risk of progression than their younger counterparts, even if their CD4+ T-cell counts are the same. Hence, prophylaxis against opportunistic infections may be indicated at higher CD4+ T-cell counts in older people than in younger people.
An Innovative Tool to Measure Human Skin Strain Distribution in Vivo using Motion Capture and Delaunay Mesh (2012)

Abstract Skin has a complex structure and its deformation mechanics is still not well defined. In the study of skin biomechanics, the stretch ratio, λ, is an important property, which is determined using strain data. This paper attempts to develop a novel tool by integrating experimental-numerical approach to measure full-field strain distribution of human skin in vivo. Skin deformation in vivo was measured using motion capture system, (which is not a full-field measuring tool) and then by constructing finite elements, its full-field strain contour is produced. The experimental procedure starts by attaching a set of reflective markers onto the skin at the forearm of healthy volunteers. Skin deformation is induced by pulling a nylon filament attached with a loading tab. Three infrared cameras are used to capture the movement of markers during load application. QTM (Qualisys, Sweden) software is used to track markers trajectories and generate data consisting of 3-dimensional markers coordinate. The initial capture is set as the reference marker positions (undeformed skin) and the subsequent images represent the deformed skin relative to the initial. Representing markers as nodes, finite elements are constructed by adjoining three adjacent markers using Delaunay mesh. Strains were deduced from the strain displacement matrix and measured for three subjects at three loading directions. The results are in fair agreement with those obtained by others. The method and output provide a useful addition to understanding skin deformation.
Some recent developments in “integrated electronics” (1961)

Integrated electronics is the new frontier in the development of the electronics industry. It characterizes microsystems in which the number of parts are considerably less than the number of equivalent components. Some of the steps in the development of microsystems leading to the process of integrated electronics are briefly described and illustrated by several working devices.
CATECHOLAMINES IN FETAL AND NEWBORN RAT BRAIN (1973)

Abstract The levels of dopamine and norepinephrine were determined in the brains of fetal and newborn rats by means of a sensitive, radiometric‐enzymatic assay. Catecholamines were converted to their 3‐ O ‐methylated derivatives in the presence of catechol‐ O ‐methyl transferase (EC 2.1.1.1) and [ 3 H‐methyl]S‐adenosylmethionine; and the [ 3 H]‐derivatives were isolated by selective extraction. The assay had a sensitivity for dopamine and norepinephrine of 100 picograms and was linear to at least 30 nanograms of catecholamines. Both amines were present at 15 days of gestation and increased 15‐fold in content during the last week of gestation. The regional distribution of these neurotransmitters in the brain of the newborn rat correlated with the distribution of their biosynthetic enzymes. An investigation of the effects of reserpine, pheniprazine, α‐methyl‐ para ‐tyrosine, diethyldithiocarbamate and l ‐DOPA on the levels of dopamine and norepinephrine in the brains of the 18‐day gestational fetus indicated that the levels of these neurotransmitters are under controls similar to those known to occur in the brain of the adult rat.
A Video Watermarking DRM Method Based on H.264 Compressed Domain with Low Bit‐Rate Increasement (2016)

It gets more and more important for video copyright protection, it is necessary to provide efficient H.264 compression domain watermarking for video Digital rights management(DRM). A new watermarking method based on H.264 compressed domain is proposed for video DRM, in which the embedding and extracting procedure are performed using the syntactic elements of the compressed bit stream. In this way, complete decoding is unnecessary in both embedding and extracting processes. Based on the analysis of the time and space, some appropriate sub-blocks are selected for embedding watermarks, increasing watermark robustness while reducing the declination of the visual quality. In order to avoid bit-rate increasing and strengthen the security of the proposed video watermarking scheme, only a set of nonzero coefficients quantized in different parts of macroblocks is chosen for inserting watermark. The experiment results show the proposed scheme can achieve excellent robustness against some common attacks, the proposed scheme is secure and efficient for video content DRM protection.
Le contexte artistique (2006)

En Angleterre Le rôle d’avant-garde de quelques personnalités Augustus Welby Pugin (1812-1852) et Henry Cole (1808-1882) Les origines du mouvement anglais pour l’amélioration du goût dans le dessin remontent au xixe siècle, aux écrits de l’architecte et « designer » Augustus Welby Pugin, à son rêve de réunir dessinateur et artisan et à la création des premières écoles de « design ». Pour endiguer ce qu’il appelait « le déclin actuel du goût », il se tourna vers l’Angleterre préindustrielle, i...
Molecular Cloning and Sequencing of Cell Wall Hydrolase Gene of an Alkalophilic Bacillus subtilis BL-29 (1997)

A DNA fragment containing the gene for cell wall hydrolase of alkalophilic Bacillus subtilis BL-29 was cloned into E. coli JM109 using pUC18 as a vector. A recombinant plasmid, designated pCWL45B, was contained in the fragment originating from the alkalophilic B. subtilis BL-29 chromosomal DNA by Southern hybridization analysis. The nucleotide sequence of a 1.6-kb HindIII fragment containing a cell wall hydrolase-encoding gene was determined. The nucleotide sequence revealed an open reading frame (ORF) of 900 bp with a concensus ribosome-binding site located 6 nucleotide upstream from the ATG start codon. The primary amino acid sequence deduced from the nucleotide sequence revealed a putative protein of 299 amino acid residues with an M.W. of 33, 206. Based on comparison of the amino acid sequence of the ORF with amino acid sequences in the GenBank data, it showed significant homology to the sequence of cell wall amidase of the PBSX bacteriophage of B. subtilis.
Lower Critical Solution Temperature Behavior of Linear Polymers in Ionic Liquids and the Corresponding Volume Phase Transition of Polymer Gels (2006)

Poly(benzyl methacrylate) (PBzMA) and its copolymers exhibit lower critical solution temperature (LCST)-type phase separation in common hydrophobic ionic liquids (ILs) such as 1-ethyl-3-methylimidazolium bis(trifluoromethane sulfone)imide ([C(2)mim][NTf2]). The turbidity measurements for PBzMA/IL mixed systems reveal that the LCST-type phase separation temperatures change significantly with the changes in the chemical structures of polymers and ILs. Moreover, cross-linked PBzMA gels show reversible and discontinuous volume phase transition in [C(2)mim][NTf2] with the changes in temperature.
Irritation factors of sodium hypochlorite solutions in human skin (1990)

The recommended concentration for patch testing with sodium hypochlorite [NaOCl] (bleach) is 1%, generally obtained by diluting commercial bleach. In doing so, other active (potentially irritant) components of bleach, especially hypochlorous acid [HOCl] and sodium hydroxide [NaOH], are neglected. Magnitudes of potential irritant species other than NaOCl, such as alkalinity, are ordinarily not labeled on the product, though they may vary considerably between brands. Thus, patch testing with 1% hypochlorite obtained by diluting different brand bleaches can potentially elicit non-specific irritant responses, also depending upon the test volume applied. In this study, skin irritation induced by 24-h patch testing with 20 microliters or 100 microliters, with constant NaOCl concentration (1%) and different NaOH concentrations (0.01-1.0%), was studied in adult human volunteers, by means of visual scores and skin color reflectance measurements. No irritation was elicited by application of 20 microliters 1% OCl-, independent of the NaOH concentration. However, all solutions induced significant irritation in a volume of 100 microliters. Skin reactions did not show a straight pH dose response, a maximum reaction being seen to the solution containing 0.1% NaOH. Skin surface pH values had increased when monitored immediately after removal of the patch material. However, 24 h later, baseline values were again reached at most sites, demonstrating an efficient buffering capacity of human skin, even after challenge with alkaline solutions of pH 13.4. We suggest that a non-irritant concentration for diagnostic patch testing for allergic contact dermatitis with an aluminum chamber, using 17 microliters to 20 microliters test volume, could be as high as 1% NaOCl and 1% NaOH.
The H in HPER (1967)

(1967). The H in HPER. Journal of Health, Physical Education, Recreation: Vol. 38, No. 2, pp. 22-62.
Effects of ion implantation on friction and wear of stainless steels. [15-5PH] (1982)

Friction and wear of 304, 15-5 PH and 440C stainless steels and of pure Fe are shown to be reduced by ion implantation of Ti and C. Mechanically polished samples were ion implanted to fluences of 2 x 10/sup 15/ Ti/mm/sup 2/ (90 to 180 keV) and 2 x 10/sup 15/ C/mm/sup 2/ (30 keV); the implantation profiles of the two elements extended to approx. 0.1 ..mu..m and approximately overlapped each other. The effects of normal load (Hertzian stresses in the range of 690 to 1840 MPa) on friction and wear were evaluated in the pin-on-disc configuration with no lubrication. 304 pins were used and are shown to give results similar to those previously reported for 440C pins. Ion implantation reduces friction coefficients by up to 80% and decreases the maximum wear depths by up to 95%, but the magnitude of reductions depends on the material and the load conditions. Transfer of material containing Ti from the implanted plates to both 304 and 440C pins was observed. A change in wear mechanism was detected in the wear tracks as the load was increased: fine-scale abrasive-type parallel grooves were present at light loads while galling was observed at high loads. 6more » figures.« less
Data driven workflow planning in cluster management systems (2007)

Traditional scientific computing has been associated with harnessing computation cycles within and across clusters of machines. In recent years, scientific applications have become increasingly data-intensive. This is especially true in the fields of astronomy and high energy physics. Furthermore, the lowered cost of disks and commodity machines has led to a dramatic increase in the amount of free disk space spread across machines in a cluster. This space is not being exploited by traditional distributed computing tools. In this paper we have evaluated ways to improve the data management capabilities of Condor, a popular distributed computing system. We have augmented the Condor system by providing the capability to store data used and produced by workflows on the disks of machines in the cluster. We have also replaced the Condor matchmaker with a new workflow planning framework that is cognizant of dependencies between jobs in a workflow and exploits these new data storage capabilities to produce workflow schedules. We show that our data caching and workflow planning framework can significantly reduce response times for data-intensive workflows by reducing data transfer over the network in a cluster. We also consider ways in which this planning framework can be made adaptive in a dynamic, multi-user, failure-prone environment.
Websites that satisfy users: a theoretical framework for Web user interface design and evaluation (2003)

With the fast development and increasing use of the World Wide Web as both an information seeking and an electronic commerce tool, Web usability studies are growing in importance. While Web designers have largely focused on the functional aspects of Web sites, there has been little systematic attention to (1) the motivational issues of Web user interface design or (2) a theoretically-driven approach to Web user satisfaction studies. The objective of this paper is to provide a conceptual framework and foundation for systematically investigating features in the Web environment that contribute to user satisfaction with a Web interface. This research uses F. Herzberg's (1966) motivation-hygiene theory to guide the identification of these features. Among the implications and contributions of this research are the identification of Web design features that may maximize the likelihood of user satisfaction and return visits to the Web site.
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure (2014)

Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs. siRNA is recognized and processed by Ago2 and C3PO, endonucleases of the RNA-induced silencing complex (RISC). RISC cleaves passenger RNA, exposing the guide RNA for base-pairing with its homologous mRNA target. Remarkably, the 3' end of passenger RNA can accommodate a DNA extension of 19-nucleotides without loss of RNAi function. This construct is termed passenger-3'-DNA/ds siRNA and includes a 3'-nuclease-resistant mini-hairpin structure. To test this novel modification further, we have now compared the following constructs: (I) guide-3'-DNA/ds siRNA, (II) passenger-3'-DNA/ds siRNA, (III) guide-3'-DNA/ss siRNA, and (IV) passenger-3'-DNA/ss siRNA. The RNAi target was SIRT1, a cancer-specific survival factor. Constructs I-III each induced selective knock-down of SIRT1 mRNA and protein in both noncancer and cancer cells, accompanied by apoptotic cell death in the cancer cells. Construct IV, which lacks the SIRT1 guide strand, had no effect. Importantly, the 3'-DNA mini-hairpin conferred nuclease resistance to constructs I and II. Resistance required the double-stranded RNA structure since single-stranded guide-3'-DNA/ss siRNA (construct III) was susceptible to serum nucleases with associated loss of RNAi activity. The potential applications of 3'-DNA/siRNA constructs are discussed.Molecular Therapy-Nucleic Acids (2014) 2, e141; doi:10.1038/mtna.2013.68; published online 7 January 2014.
Channel ordering for VLSI layout with rectilinear modules (1991)

The authors present a channel-ordering algorithm for VLSI layout with rectilinear modules. Existing approaches for layout with rectangular modules using only straight and L-shaped channels are no longer applicable. In general, rectilinear channels are needed. An important class of channels, called staircase channels, is introduced. This algorithm produces a feasible channel ordering which minimizes the usage of nonstaircase channels and minimizes the number of corners in a channel.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Preliminary survey of the Helvellaceae from Xinjiang, China (2004)

Xinjiang is in the northwest of China. It occupies more than 1/7 of the China mainland territory (Fig. 1). The area is covered with deserts, grasslands, conifer forests, broadleaf trees, and shrubs.……
Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications in C57BL/6J Mice (2012)

The objective of this study was to determine the effects of muscadine grape or wine (cv. Noble) phytochemicals on obesity and associated metabolic complications. Muscadine grape or wine phytochemicals were extracted using Amberlite FPX66 resin. Male C57BL/6J mice were given a low-fat diet (LF, 10% kcal fat), high-fat diet (HF, 60% kcal fat), HF + 0.4% muscadine grape phytochemicals (HF+MGP), or HF + 0.4% muscadine wine phytochemicals (HF+MWP) for 15 weeks. At 7 weeks, mice fed HF+MGP had significantly decreased body weights by 12% compared to HF controls. Dietary MGP or MWP supplementation reduced plasma content of free fatty acids, triglycerides, and cholesterol in obese mice. Inflammation was alleviated, and activity of glutathione peroxidase was enhanced. Consumption of MGP or MWP improved insulin sensitivity and glucose control in mice. Thus, consumption of muscadine grape and wine phytochemicals in the diet may help to prevent obesity-related metabolic complications.
Gut microbiota richness promotes its stability upon increased dietary fibre intake in healthy adults (2015)

Gut microbiota richness and stability are important parameters in host-microbe symbiosis. Diet modification, notably using dietary fibres, might be a way to restore a high richness and stability in the gut microbiota. In this work, during a 6-week nutritional trial, 19 healthy adults consumed a basal diet supplemented with 10 or 40 g dietary fibre per day for 5 days, followed by 15-day washout periods. Fecal samples were analysed by a combination of 16S rRNA gene pyrosequencing, intestinal cell genotoxicity assay, metatranscriptomics sequencing approach and short-chain fatty analysis. This short-term change in the dietary fibre level did not have the same impact for all individuals but remained significant within each individual gut microbiota at genus level. Higher microbiota richness was associated with higher microbiota stability upon increased dietary fibre intake. Increasing fibre modulated the expression of numerous microbiota metabolic pathways such as glycan metabolism, with genes encoding carbohydrate-active enzymes active on fibre or host glycans. High microbial richness was also associated with high proportions of Prevotella and Coprococcus species and high levels of caproate and valerate. This study provides new insights on the role of gut microbial richness in healthy adults upon dietary changes and host microbes' interaction.
Construction of (Z,Z ) skipped 1,4-dienes. Application to the synthesis of polyunsaturated fatty acids and derivatives † (2000)

Covering: 1957 to the end of 1998.