gebhart/patrepeval huggingface dataset:
Two translocations of chromosome 15q associated with dyslexia (2000)

Developmental dyslexia is characterised by difficulties in learning to read. As reading is a complex cognitive process, multiple genes are expected to contribute to the pathogenesis of dyslexia. The genetics of dyslexia has been a target of molecular studies during recent years, but so far no genes have been identified. However, a locus for dyslexia on chromosome 15q21 (DYX1) has been established in previous linkage studies. We have identified two families with balanced translocations involving the 15q21-q22 region. In one family, the translocation segregates with specific dyslexia in three family members. In the other family, the translocation is associated with dyslexia in one family member. We have performed fluorescence in situ hybridisation (FISH) studies to refine the position of the putative dyslexia locus further. Our results indicate that both translocation breakpoints on 15q map within an interval of approximately 6-8 Mb between markers D15S143 and D15S1029, further supporting the presence of a locus for specific dyslexia on 15q21.
Successful In Utero Intervention for Bilateral Renal Agenesis (2014)

Serial amnioinfusion appears to have mitigated the severe pulmonary compromise that has, in the past, led to the death of newborns with bilateral renal agenesis.
Generation of bandwidth-limited pulses from a TEA CO2 laser using <i>p</i>-type germanium (1974)

Passive mode locking of a TEA CO2 laser using p-type germanium as a saturable absorber is described. Pulses of about 0.5-ns duration are obtained.
Regulation of Metallothionein Transcription by the Metal-responsive Transcription Factor MTF-1 (2002)

Every living organism must detoxify nonessential metals and carefully control the intracellular concentration of essential metals. Metallothioneins, which are small, cysteine-rich, metal-binding proteins, play an important role in these processes. In addition, the transcription of their cognate genes is activated in response to metal exposure. The zinc finger transcription factor MTF-1 plays a central role in the metal-inducible transcriptional activation of metallothionein and other genes involved in metal homeostasis and cellular stress response. Here we report that the phosphorylation of MTF-1 plays a critical role in its activation by zinc and cadmium. Inhibitor studies indicate that multiple kinases and signal transduction cascades, including those mediated by protein kinase C, tyrosine kinase, and casein kinase II, are essential for zinc- and cadmium-inducible transcriptional activation. In addition, calcium signaling is also involved in regulating metal-activated transcription. In contrast, cAMP-dependent protein kinase may not be directly involved in the metal response. Contrary to what has been reported for other transcription factors, inhibition of transcriptional activation does not impair the binding of MTF-1 to DNA, suggesting that phosphorylation is not regulating DNA binding. Elevated phosphorylation of MTF-1 is observed under condition of protein kinase C inhibition, suggesting that specific dephosphorylation of this transcription factor contributes to its activation.
A new phonocardiographic recording system (2002)

Describes a new system for recording, processing, and analyzing heart sounds. The equipment consists of a separate handheld electronic stethoscope, headphones connected to the stethoscope, personal computer with sound handling capabilites, and special software for recording and analyzing the heart sounds. The developed system enables various processes and studies of the heart sounds and murmurs in a wide frequency spectrum from 20 Hz to 22 kHz. According to the authors' experience the system is helpful in screening of the murmurs of children. In addition, the authors think the system would also be helpful in evaluation and follow up of valve defects of adults, particularly in cases when there is no possibility to ultrasound examinations. Further studies to evaluate the clinical value of the system are in progress.
Low-noise and broadband optical frequency comb generation based on an optoelectronic oscillator (2014)

A novel scheme to generate broadband high-repetition-rate optical frequency combs and low phase noise microwave signals simultaneously is proposed and experimentally demonstrated. By incorporating an optical frequency comb generator in an optoelectronic oscillator loop, more than 200 lines are generated for a 25 GHz optical frequency comb, and the single-sideband phase noise is as low as -122 dBc/Hz at 10 kHz offset for the 25 GHz microwave signal. 10 and 20 GHz optical frequency combs and microwave signals are also generated. Unlike the microwave frequency synthesizer, the phase noise of the microwave signals generated by this new scheme is frequency independent.
Sublingual Administration of an Adenovirus Serotype 5 (Ad5)-Based Vaccine Confirms Toll-Like Receptor Agonist Activity in the Oral Cavity and Elicits Improved Mucosal and Systemic Cell-Mediated Responses against HIV Antigens despite Preexisting Ad5 Immunity (2010)

HIV/AIDS continue to devastate populations worldwide. Recent studies suggest that vaccines that induce beneficial immune responses in the mucosal compartment may improve the efficacy of HIV vaccines. Adenovirus serotype 5 (Ad5)-based vectors remain a promising platform for the development of effective vaccines. In an effort to improve the efficacy of Ad5-based vaccines, even in the presence of preexisting Ad5 immunity, we evaluated the potential for an Ad5-based HIV vaccine to induce antigen-specific immune responses following sublingual (s.l.) administration, a route not previously tested in regard to Ad-based vaccines. s.l. vaccination with an Ad5-based HIV-Gag vaccine resulted in a significant induction of Gag-specific cytotoxic T-lymphocyte (CTL) responses in both the systemic and the mucosal compartment. We also show that s.l. immunization not only avoided preexisting Ad5 immunity but also elicited a broad repertoire of antigen-specific CTL clones. Additionally, we confirm for the first time that oral delivery of a vaccine expressing a potent Toll-like receptor (TLR) agonist can stimulate innate immune responses through induction of cytokines and chemokines and activation of NK cells, NKT cells, and macrophages in vivo. These results positively correlated with improved antigen-specific CTL responses. These results could be achieved both in Ad5-naïve mice and in mice with preexisting immunity to Ad5. The simplicity of the s.l. vaccination regimen coupled with augmentation of TLR-dependent pathways active in the oral cavity makes s.l. delivery a promising method for HIV vaccine development specifically, as well as for many other vaccine applications in general.
Working with XML (2003)

The promise of XML has been, among other things, the ability to store data in just about any format you need; but, as you may have suspected, you have a somewhat limited range of choices for data storage in the .NET Compact Framework. Your choices? SQL Server CE, custom data files, text files, or XML files. We spent the last three chapters discussing SQL Server CE, and that might be your best option based on the business model that you're working under. However, there are situations in which you might not want to use SQL Server CE, even in its disconnected mode. In that case, you're pretty much reduced to using either your own data file format or XML files to store your data.
Exploratory Spatial Data Analysis of Motor Neurone Disease in North West England: Beyond the Address at Diagnosis (1998)

This paper addresses the issues surrounding an individual’s exposure to potential environmental risk factors which can be implicated in the aetiology of a disease. We hope to further elucidate the ‘lag’ or latency period between the initial exposure to potential pathogens and the physical emergence of the disease, with specific reference to the rare neurological condition, Motor Neurone Disease (MND). A Space-Time approach is adopted, whereby patterns in both time and space are considered. No prior assumptions about the aetiology of MND are adopted. By using methods for the analysis of point processes, which preserve the continuous nature of the data, we resolve some of the problems of analysis based on often arbitrary areal units, such as postcode boundaries, or political boundaries, which diseases do not respect. We use kernel estimation to model Space-Time patterns. Raised relative risk is assessed by adopting appropriate adjustments for the underlying population at risk, with the use of controls. Significance of the results are assessed using Monte-Carlo simulation. Our results demonstrate the utility of kernel estimation as a visualisation tool. Small areas of elevated risk appear to have been identified, which need to be more closely examined before any firm conclusions can be drawn. We highlight a number of issues concerning the inadequacies of the data, and possibly of the techniques themselves. Various modifications have been proposed, with the most promising being adaptive kernel estimation.
Rhodium-catalyzed asymmetric arylation of N- and O-containing cyclic aldimines: facile and efficient access to highly optically active 3,4-dihydrobenzo[1,4]oxazin-2-ones and dihydroquinoxalinones (2016)

A highly enantioselective Rh-catalyzed arylation of benzoxazinones and quinoxalinones with arylboroxines was realized for the first time by employing a simple sulfur-olefin as the ligand.
Optimal algorithms for the channel-assignment problem on a reconfigurable array of processors with wider bus networks (2002)

The computation model on which the algorithms are developed is the reconfigurable array of processors with wider bus networks (abbreviated to RAPWBN). The main difference between the RAPWBN model and other existing reconfigurable parallel processing systems is that the bus width of each network is bounded within the range [2,[/spl radic/(N)]]. Such a strategy not only saves the silicon area of the chip as well as increases the computational power enormously, but the strategy also allows the execution speed of the proposed algorithms to be tuned by the bus bandwidth. To demonstrate the computational power of the RAPWBN, the channel-assignment problem is derived in this paper. For the channel-assignment problem with N pairs of components, we first design an O(T + [N//spl omega/]) time parallel algorithm using 2N processors with a 2N-row by 2N-column bus network, where the bus width of each bus network is /spl omega/-bit for 2 /spl les/ /spl omega/ /spl les/ [/spl radic/N] and T = [log/sub /spl omega//N] + 1. By tuning the bus bandwidth to the natural log N-bit and the extended N/sup 1/c/-bit (N/sup 1/c/ > log N) for any constant c and c /spl ges/ 1, two more results which run in O(log N/log log N) and O(1) time, respectively, are also derived. When compared to the algorithms proposed by Olariu et al. [17] and Lin [14], it is shown that our algorithm runs in the equivalent time complexity while significantly reducing the number of processors to O(N).
Reversible anion radical–dianion redox equilibria involving ions of simple aromatic compounds (1974)

Anthracene, benzophenone, nitrobenzene, and several other simple aromatic compounds undergo two consecutive reversible one-electron transfers to give first the anion radical and then the dianion, both species being stable during the time scale of cyclic voltammetry in several electrophile-free solvents.
An adaptive virtual path allocation policy for broadband networks (2002)

We propose a new policy for virtual path bandwidth allocation in broadband networks. Based on a threshold scheme, our policy handles the inherent tradeoff between bandwidth utilization and processing costs. In each virtual path controller the thresholds are chosen so as to keep bandwidth utilization high, while obtaining a low rate of processing requests. Two novel ideas are used in our threshold scheme: adaptivity, which results in a better prediction of future bandwidth requirements; and hysteresis, which prevents excessive processing of requests due to oscillations around thresholds. We tested the performance of our new bandwidth control scheme, and compared it with previously suggested schemes. The performance measures were the expected amount of unused bandwidth, the average signaling load and the blocking probability. Performance has been evaluated through numerical computations as well as by simulations. Our analysis is based on a time segmentation technique which allows us to reduce a Markov chain with NM states into M Markov chains with N states and a one-dimensional chain with M states. Our results show that our policy significantly improves upon previously suggested approaches.
A Fast Algorithm for the Chirp Rate Estimation (2008)

A fast algorithm for the chirp rate estimation is presented in this paper. By the computation of the cubic phase transform (CPT) of the signal, it is shown that the CPT is concentrated along the frequency rate law of the signal, and the peak of the CPT yields the estimate of the chirp rate. The proposed algorithm is fast in that it requires only one-dimensional (1-D) maximizations. The asymptotic statistical result is derived for the chirp rate estimation, and the computer simulation demonstrates that, when the input signal-to-noise ratio (SNR) is higher than -2 dB, the simulation results and the theoretical analyses are well matched, and the mean-square error (MSE) approaches optimality as the SNR tends to infinity.
Low-Cost Flow Batteries (2014)

RETURN TO ISSUEPREVNewsNEXTLow-Cost Flow BatteriesCite this: Chem. Eng. News 2014, 92, 2, 4Publication Date (Print):January 13, 2014Publication History Published online31 March 2015Published inissue 13 January 2014https://pubs.acs.org/doi/10.1021/cen-09202-notw1https://doi.org/10.1021/cen-09202-notw1newsACS PublicationsCopyright © 2014 Chemical & Engineering NewsArticle Views12Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Batteries,Electrical energy Get e-Alerts
Probabilistic matching of image- to model-features for real-time object tracking (2003)

Background clutter produces a difficult problem for edge matching within model-based object tracking approaches. The solution of matching all possible candidate image features with the model features is computationally infeasible for real-time tracking. The authors propose to draw probabilistic samples of candidate sets based on measures for local topological constraints. Line features have parallel and junction constraints. Continuous measures are used for evaluation of matching of the feature sets to avoid thresholds. This approach limits the number of matchings and processing time increases linearly with the number of features. Experiments show the correct selection among multiple candidates for different scenarios.
Anti‐alias optimal interpolation with priors (2010)

We introduce a new technique referred to as Optimal Interpolation with Priors, or OIP, for interpolation of irregularly sampled signals, using prior estimates of their spectral content, which is optimal in the least square sense. In this paper, after introducing this technique and describing its basic advantages with respect to other state of the art regularization techniques, we demonstrate its potential to interpolate signals that are spatially aliased, based on realistic prior information. We also propose an algorithm to obtain a reliable prior estimate of the signal spectrum. The combined use of this algorithm and OIP, referred to henceforth as Anti‐Alias OIP (AA‐OIP), can be applied to datasets irregularly sampled in multidimensional spaces.
Gender, Culture, and Suicidal Behavior: A Feminist Critique of Theories and Research (1998)

Suicide research has developed historically from philosophical roots in logical positivism and structural determinism. Thus, much suicide research has been based on assumptions of cause-and-effect relationships, reductionistic analysis, and the individual as the primary unit of analysis. In counterpoint, six guiding themes define feminist research (Worell & Etaugh, 1994). The present manuscript traces these six themes, illustrating them with suicide research projects. By challenging scientific tradition, focusing on women, considering power, recognizing gender constructs, maintaining awareness of the power of language, and promoting active, practical applications, researchers can combine traditional and alternative methodologies to make suicide research more robust.
Analysis of a New PM Motor Design for a Rotary Dynamic Blood Pump (1997)

The permanent magnet (PM) motor for a rotary dynamic blood pump requires high power density to coordinate the motor size with the limited pump space and high efficiency to reduce the size and weight of the associated batteries. The motor also serves as a passive axial magnetic thrust bearing, a reacting hydraulic force, and provides a stabilizing force for the radial journal bearing. This article presents analysis of a new PM motor for the blood pump application. High power density is achieved by using the Halbach magnetic array, and high efficiency is accomplished by optimizing the rotor magnet assembly and the stator slots/windings. While both radial and axial forces are greatly enhanced, pulsating components of the torque and force are also significantly reduced.
Effects of Topically Delivered Benzamil and Amiloride on Nasal Potential Difference in Cystic Fibrosis (1998)

The raised nasal transepithelial potential difference (PD) in cystic fibrosis (CF) reflects accelerated active transport of Na+, and is inhibited by topical administration of the Na+ channel blocker, amiloride. The aim of this study was to investigate the dose-effect and time course of topically administered Na+ conductance inhibitors to inhibit nasal PD, including benzamil, an analog of amiloride. We measured the magnitude of drug inhibition of Na+ transport [percent inhibition of baseline PD (DeltaPD%)] and duration of inhibition of PD, defined as the time when drug inhibition of PD had recovered by 50% (effective time = ET50). Amiloride [10(-)3 M (n = 16), 3 x 10(-)3 M (n = 9), 6 x 10(-)3 M (n = 7), 10(-)2 M (n = 3)] or benzamil [1.7 x 10(-)3 M (n = 7), and 7 x 10(-)3 M (n = 5)] were administered to the nasal surface via an aerosol generated by a jet nebulizer and a nasal mask. The concentration-dependent magnitude (DeltaPD%) of inhibition was similar for amiloride and benzamil ( approximately 67- 77%), whereas the duration of inhibition (ET50) was about two-and-a-half times longer after benzamil administration as compared with equivalent concentrations of amiloride [1.6 +/- 0. 06 versus 4.5 +/- 0.6 h (ET50 +/- SEM), at 6-7 x 10(-)3 M]. In vitro studies of cultured normal nasal epithelia demonstrated directly that benzamil induced an approximately 2-fold more prolonged inhibition of active Na+ transport than amiloride. These data suggest aerosolized benzamil is a candidate long-duration Na+ channel blocker for CF.
Preparation of Nitrogen-Doped Graphene Sheets by a Combined Chemical and Hydrothermal Reduction of Graphene Oxide (2010)

Nitrogen-doped graphene sheets were prepared through a hydrothermal reduction of colloidal dispersions of graphite oxide in the presence of hydrazine and ammonia at pH of 10. The effect of hydrothermal temperature on the structure, morphology, and surface chemistry of as-prepared graphene sheets were investigated though XRD, N(2) adsorption, solid-state (13)C NMR, SEM, TEM, and XPS characterizations. Oxygen reduction and nitrogen doping were achieved simultaneously under the hydrothermal reaction. Up to 5% nitrogen-doped graphene sheets with slightly wrinkled and folded feature were obtained at the relative low hydrothermal temperature. With the increase of hydrothermal temperature, the nitrogen content decreased slightly and more pyridinic N incorporated into the graphene network. Meanwhile, a jellyfish-like graphene structure was formed by self-organization of graphene sheets at the hydrothermal temperature of 160 °C. Further increase of the temperature to 200 °C, graphene sheets could self-aggregate into agglomerate particles but still contained doping level of 4 wt % N. The unique hydrothermal environment should play an important role in the nitrogen doping and the jellyfish-like graphene formation. This simple hydrothermal method could provide the synthesis of nitrogen-doped graphene sheets in large scale for various practical applications.
Multistage neural network for pattern recognition in mammogram screening (1994)

A novel multistage neural network (MSNN) is proposed for locating and classification of micro-calcification in digital mammography. Backpropagation (BP) with Kalman filtering (KF) is used for training the MSNN. A new nonlinear decision method is proposed to improve the performance of the classification. The experimental results show that the sensitivity of this classification/detection is 100% with the false positive detection rate of less than 1 micro-calcification clusters (MCCs) per image. The proposed methods are automatic or operator independent and provide realistic image processing times as required for breast cancer screening programs. Full clinical analysis is planned using large databases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
NeuroScale: Novel Topographic Feature Extraction using RBF Networks (1996)

Dimension-reducing feature extraction neural network techniques which also preserve neighbourhood relationships in data have traditionally been the exclusive domain of Kohonen self organising maps. Recently, we introduced a novel dimension-reducing feature extraction process, which is also topographic, based upon a Radial Basis Function architecture. It has been observed that the generalisation performance of the system is broadly insensitive to model order complexity and other smoothing factors such as the kernel widths, contrary to intuition derived from supervised neural network models. In this paper we provide an effective demonstration of this property and give a theoretical justification for the apparent `self-regularising&apos; behaviour of the `NeuroScale&apos; architecture.