gebhart/patrepeval huggingface dataset:
The Digital Soft Braking for Wind Turbine (2010)

The mathematical models of hydraulic braking system were built through studying the braking system of the wind turbine. The AMESim software was used to establish the simulation model of hydraulic braking system and the controller model, which was employed to the coupling of the simulation, constructed in Matlab/Simulink. The designed soft braking system was tested in the wind turbine. The analysis results of the simulation and the test show that the rotor speed decreases gently and the fluctuation of the gearbox torque is diminished at the soft braking based on adjusting the duty cycle of PWM which controls the ON/OFF of the high-speed switch valve.
A low ripple on-chip charge pump for bootstrapping of the noise-sensistive nodes (2006)

Charge pump with less than 1 mV ripple of the output voltage employs on-chip capacitors with large parasitic capacitance between bottom plate and substrate and does not generate pulsed supply current or noticeable substrate noise during switching. It operates in current mode and is developed with structural approach to analog design that uses dedicated feedback loop for every important parameter.
A Low Complexity Frequency Domain Iterative Decision-Directed Channel Estimation Technique for Single-Carrier Systems (2007)

A low complexity frequency domain iterative decision-directed channel estimation (FD-IDDCE) technique for single-carrier (SC) systems with frequency domain multiplexed (FDM) pilots is proposed. The tentative hard decisions from either the frequency domain equalizer output or the Viterbi decoder output are used as extra pilots to further improve the initial frequency channel estimates using a cascaded 2 times 1D Wiener filter. The issue of noise enhancement when finding the least square (LS) estimates of the channel frequency response (CFR) using the tentative decisions in the frequency domain is overcome by the so called frequency replacement algorithm, which replaces the noise enhanced LS estimates of the CFR with the corresponding channel frequency estimates in the previous iteration, by comparing with a threshold. Using the proposed FD-IDDCE, the frame error rate (FER) performance for coded SC systems using FDM pilots with frequency expanding technique and frequency domain superimposed pilot technique was found to be about 0.4 dB and about 1 dB away from the FER performance with known CFR at FER=10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> .
Characterization and optimization of glycerol/sebacate ratio in poly(glycerol-sebacate) elastomer for cell culture application (2013)

Poly(glycerol-sebacate) (PGS) is an elastomeric biodegradable polyester. Our previous series of studies have showed that PGS has good biocompatibility. In view of the potential use of PGS in bioengineering, we attempt to characterize the PGS polymer with different ratio of glycerol and sebacic acid, and the cell adhesion and growth on these polymers. PGSs with different proportion of glycerol and sebacic acid were synthesized by polycondensation reaction. The microstructure of the series PGSs were characterized by infrared spectroscopy and X-ray diffraction analysis (XRD). Results showed that, with the increase of the ratio of sebacic acid in PGS from 1:0.8, 1:1, to 1:1.2 (ratio of glycerol to sebacic acid), the main diffraction peak in XRD, the sol content and gel swelling increased but then decreased, suggesting that the degree of crosslinking and the inherent degree of order of the series PGS increased and then decreased. With the increase of sebacic acid proportion, water absorption increased and then decreased, and the water absorption ranged from 9.62% to 10.66%. The mass loss of the series of samples in degradation experiments ranged from 24.63% to 40.06% on the 32nd day of degradation. Cell culture data suggested that the polymer with the ratio of 1:0.8 for glycerol and sebacate was suitable for cell adhesion and growth. In conclusion, PGS can be used as the cell culture matrix by modifying the composition ratio of glycerol and sebacic acid to improve the properties of cell adhesion and growth. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3903–3907, 2014.
Treatment of Hemophilus vaginalis vaginitis. (1981)

Four antimicrobial agents (triple sulfa cream, doxycycline, ampicillin, and metronidazole) were studied by double-blind techniques to determine their effectiveness in the treatment of Hemophilus vaginalis vaginitis, documented by vaginal culture in 96 patients. Cure was confirmed by negative vaginal cultures 7 weeks after the start of therapy. Metronidazole proved to be effective in 20 of 22 couples (90.9%) treated. Sulfa cream, doxycycline, and ampicillin were effective in 47.8 to 63.6% of patients treated.
[Effect of a vitamin complex with mineral substances on blood coagulation in rats when administered by different methods and in experimental hypercoagulation]. (1986)

Experiments conducted on white rats have evidenced that a single injection of a complex of vitamins with mineral substances ("Complivit") in doses similar to the therapeutic induces a short-term hupocoagulemia, which is reproduced during long-term administration. The animals tolerance to thromboplastin is significantly increased in the period of hypocoagulemia. It is suggested that the complex can produce a favourable effect in cases with hypercoagulemia.
IGF-I and IGF binding proteins in diabetes-related kidney growth. (1992)

The kidney is a site of insulin-like growth factor I (IGF-I) production and IGF-I mediates effects on kidney growth and function. Diabetes is associated with kidney growth in man and the rat and, in the latter, commences within 48 h of induction of diabetes. Levels of kidney IGF-I are increased during the first 2-3 days of diabetes and this is at least partially due to increased production. Additionally, IGF-I binding is increased in diabetic rat kidney, due to increased binding to the IGF-I receptor and induction of proximal tubular binding protein expression. These changes are attenuated in prepubertal rats suggesting hormonal regulation. Further studies suggest that the changes are partly GH-dependent but independent of direct sex steroid effects. As kidney growth has been implicated in the subsequent development of diabetic nephropathy, further exploration of the close association between diabetes-related kidney growth and IGF-I accumulation may lead to an improved understanding of this complication.
A comparison of two different proposed feature sets for trademark recognition using neural network (2005)

The problem of trademark recognition relates to pattern recognition. Pattern recognition needs as basis knowledge about the object. The knowledge of object can be obtained by feature extraction with image processing tools. The success of any such practical system depends critically upon how far a set of appropriate numerical attributes or features can be extracted from the object of interest for the purpose of matching or recognition. In this paper, two different combinations of image features are proposed and their comparative results for trademarks recognition are discussed. The proposed features involve some simple ratios of the image pixels as well as some geometric moments. These features are invariant to translation, rotation and scaling. The goal was achieved by segmenting the image using a connected-component (nearest neighbours) algorithm. Then the features are used as inputs for a backpropagation neural network for the learning and matching tasks. The effectiveness of the proposed feature sets is tested with various trademarks, and the results are encouraging.
Bioequivalence of encapsulated and microencapsulated fish-oil supplementation (2008)

Omega-3 oil from fish can be stabilised against oxidation using a variety of microencapsulation technologies. Complex coacervation has been used and found to be commercially useful for fortifying foods and beverages with long-chain omega-3 containing oils. Here we report a comparative human bioavailability study of microencapsulated omega-3 fish oil and standard fish-oil soft-gel capsules. Phospholipid levels of long-chain omega-3 fatty acids increased equivalently in both subjects groups. Also, triacylglycerol levels were reduced similarly in both groups. These results indicate that omega-3 fatty acids have equivalent bioavailability when delivered as microencapsulated complex coacervates or as soft-gel capsules.
Policies to bring us out of the financial crisis and recession: a speech at the Forum on Great Decisions in the Economic Crisis, College of Wooster, Wooster, Ohio, April 3, 2009 (2009)

Financial crises
Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect (2015)

1. Macrolides belong to the polyketide class of natural products. These products are a group of drugs (typically antibiotics) which their activity stems from the presence of a macrolide ring. Antibiotic macrolides are used to treat infections caused by Gram-positive bacteria and Haemophilus influenzae infections such as respiratory tract and soft-tissue infections. Macrolides, mainly erythromycin and clarithromycin, rarely show QT prolongation, as their infamous adverse reaction which can lead to torsades de pointes. Electrophysiological studies showed that macrolides prolonging the QT interval inhibit the rapid component of the delayed rectifier K(+) current (IKr) through the block of potassium channels encoded by the human ether-a-go-go-related gene (HERG). Other studies suggest that increased ROS generation alters the kinetics of hERG K(+) conductance. 2. In our study, rat cardiomyocytes were isolated with collagen perfusion technique. Finally, mitochondria isolated from cardiomyocytes were exposed to erythromycin, azithromycin and clarithromycin for their probable toxicity effects. 3. Our results demonstrated that macrolides induced reactive oxygen species formation, mitochondrial membrane permeabilization and mitochondrial swelling and finally cytochrome c release in cardiomyocyte mitochondria. 4. These findings suggested that the toxicity of heart mitochondria is a starting point for cardiotoxic effects of macrolides including QT prolongation, torsades de pointes and arrhythmia.
KEYNOTE-355: Randomized, double-blind, phase III study of pembrolizumab + chemotherapy versus placebo + chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer. (2020)

1000 Background: Pembrolizumab (pembro) monotherapy showed promising antitumor activity and manageable safety in patients (pts) with metastatic TNBC in KEYNOTE-012, -086 and -119. KEYNOTE-355 (ClinicalTrials.gov, NCT02819518) compared pembro + chemotherapy (chemo) vs placebo (pbo) + chemo for previously untreated locally recurrent inoperable or metastatic TNBC. Methods: Pts with ≥6 mo DFI were randomized 2:1 to pembro + chemo (nab-paclitaxel; paclitaxel; or gemcitabine/carboplatin) or pbo + chemo for up to 35 administrations of pembro/pbo or until progression/intolerable toxicity. Pts were stratified by chemo type (taxane vs gemcitabine/carboplatin), PD-L1 status (CPS ≥1 vs <1), and prior (neo)adjuvant treatment with same-class chemo (yes vs no). Dual primary endpoints are PFS (RECIST v1.1, blinded independent central review) and OS by tumor PD-L1 expression (CPS ≥10 and ≥1) and in all pts. PFS was estimated using the Kaplan-Meier method. Stratified log-rank tests were used to assess treatment group differences. HR and 95% CIs were based on a stratified Cox regression model. AEs were monitored throughout the study and graded per NCI CTCAE v4.0. Results: As of Dec 11 2019, median follow-up was 17.5 mo for pembro + chemo (n=566) and 15.5 mo for chemo (n=281). Pembro + chemo significantly improved PFS vs chemo alone in pts with CPS ≥10 tumors (Table), meeting one of the protocol-defined primary objectives. Although the boundary for a statistically significant benefit of pembro + chemo in pts with CPS ≥1 tumors was not met and formal testing in ITT was not performed, the pembro treatment effect increased with PD-L1 enrichment (Table). OS follow-up is ongoing. Grade 3-5 treatment-related AE rates were 68.1% with pembro + chemo (2 deaths) vs 66.9% with chemo (0 deaths); rates of grade 3-4 immune-mediated AEs and infusion reactions were 5.5% vs 0%. Clinical trial information: NCT02819518 . Conclusion: Pembro combined with several chemo partners showed a statistically significant and clinically meaningful improvement in PFS vs chemo alone in pts with previously untreated locally recurrent inoperable or metastatic TNBC whose tumors expressed PD-L1 (CPS ≥10). Pembro + chemo was generally well tolerated, with no new safety concerns. [Table: see text]
Syllabic strength and lexical boundary decisions in the perception of hypokinetic dysarthric speech (1998)

This investigation evaluated a possible source of reduced intelligibility in hypokinetic dysarthric speech, namely the mismatch between listeners' perceptual strategies and the acoustic information available in the dysarthric speech signal. A paradigm of error analysis was adopted in which listener transcriptions of phrases were coded for the presence and type of word boundary errors. Seventy listeners heard 60 phrases produced by speakers with hypokinetic dysarthria. The six-syllable phrases alternated strong and weak syllables and ranged in length from three to five words. Lexical boundary violations were defined as erroneous insertions or deletions of lexical boundaries that occurred either before strong or before weak syllables. A total of 1596 lexical boundary errors in the listeners' transcriptions was identified unanimously by three independent judges. The pattern of errors generally conformed with the predictions of the Metrical Segmentation Strategy hypothesis [Cutler and Norris, J. Exp. Psychol. 14, 113-121 (1988)] which posits that listeners attend to strong syllables to identify word onsets. However, the strength of adherence to this pattern varied across speakers. Comparison of acoustic evidence of syllabic strength to lexical boundary error patterns revealed a source of intelligibility deficit associated with this particular type of dysarthric speech pattern.
Adaptive filtering of nonlinear systems with memory by quantized mean field annealing (digital subscriber loop example) (1993)

A technique for adaptive filtering of nonlinear systems with memory that combines quantized mean field annealing (QMFA) and conventional recursive-least-squares/fast-transversal-filter (RLS/FTF) adaptive filtering is developed. This technique can efficiently handle large-order nonlinearities with or without memory. The nonlinear channel is divided into a memory nonlinearity followed by a dispersive linear system. QMFA is applied to obtain the coefficients and the order of the memory of the nonlinearity, and RLS/FTF is applied to determine the weights of the dispersive linear system. Statistical thermodynamic analysis that provides theoretical measures for making annealing algorithms computationally efficient. The method is applied to a full duplex digital subscriber loop. Simulations show a performance improvement of over 40 dB compared to ordinary RLS/FTF and steepest descent algorithms, and the solution is robust.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
3D Pendulum Swinging Control by an Industrial Robot Manipulator (2010)

Leiurotoxin I is a neurotoxin, blocker of Ca(2+)-activated apamin-sensitive K+ channel, purified from the venom of the scorpion Leiurus quinquestriatus hebraeus. It is a 31-residue polypeptide reticulated by three disulfide bridges, i.e. Cys3-Cys21, Cys8-Cys26 and Cys12-Cys28. To investigate the role of these disulfide bridges in the folding of this toxin, analogs lacking one disulfide bridge were synthesized. The structures of two analogs in which two half-cystines were placed by alpha-aminobutyrate residues to suppress one disulfide bridge, were analyzed by 1H NMR. The NMR studies reveal a three-dimensional structure identical with the native toxin for the analog lacking disulfide bridge Cys3-Cys21 and a loss of organized structure for another analog lacking disulfide bridge Cys12-Cys28. These analogs are, respectively, fully active and weakly active (2% of the residual activity) when tested in vitro for their ability to interact with their receptor channel and in vivo for their neurotoxic activity in mice. This suggest that disulfide bridge Cys12-Cys28 is essential for the folding process. In contrast, the lack of disulfide bridge Cys3-Cys21 does not affect the folding and the maintenance of bioactive conformation of Leiurotoxin I.
Rubella arthritis in adults. Isolation of virus, cytology and other aspects of the synovial reaction. (1985)

Rubella virus was isolated from three consecutive samples of synovial fluid after 1 to 4 days of arthritis in adults with typical naturally acquired rubella. In the two samples suitably prepared, cells in the synovial fluid were mononuclear, with numerous monocytes and macrophages. Detailed studies in one case revealed a close similarity in all respects to the illness caused by Ross River virus, another member of the Togaviridae. Cells in the synovial exudate of this patient showed intense phagocytosis. A fine nodular cytoplasmic distribution of virus antigen was detected by immunofluorescence in 45% of the cells. There was no depletion of the complement components C'3 and C'4 in serum or synovial fluid, and no evidence of excessive immune complexes in the circulation or of immune-complex uptake by cells in the synovial exudate or intima. Synovial intima from the suprapatellar region merely showed slight hyperplasia without cellular infiltration, indicating that the lodgement of virus and the inflammatory cellular reaction to it can be confined to limited regions of the synovial lining, at least in the early stages.
POLYCRYSTALLINE THIN FILM SOLAR CELLS:Present Status and Future Potential (1997)

▪ Abstract Polycrystalline thin film solar cells on copper indium diselenide (CulnSe 2 ) and its alloys and cadmium telluride (CdTe) appear to be the most promising candidates for large-scale application of photovoltaic energy conversion because they have shown laboratory-efficiences in excess of 15%. Heterojunction devices with n-type cadmium sulfide (CdS) films show very low minority carrier recombination at the absorber grain boundaries and at the metallurgical interface, which results in high quantum efficiences. Open circuit voltages of these devices are relatively low owing to the recombination in the space charge region in the absorber. Further improvements in efficiency can be achieved by reducing the recombination current, especially in devices based on CulnSe 2 and its alloys. Low-cost manufacturing of modules requires better resolution of a number of other technical issues. For modules based on CulnSe 2 and its alloys, the role of Na and higher deposition rates on device performance need to be better understood. In addition, replacing the chemical bath deposition method for CdS film deposition with an equally effective, but more environmentally acceptable process is needed. For modules based on CdTe, more fundamental understanding of the effect of chloride/oxygen treatment and the development of more reproducible and manufacturable CdTe contacting schemes are necessary.
Buying in better standards of care (1994)

Giving GP fundholders the power to purchase community nursing services can improve teamwork, argue two FHSA nurse advisers
An ultra-low-cost Bluetooth SOC in 0.11-&#x03BC;m CMOS (2011)

A highly-integrated, ultra-low-cost Bluetooth SOC implemented in 0.11μm digital CMOS technology is disclosed. To reduce BOM count and cost, an integrated balun is designed for the transceiver front-end. A 4xLO based VCO is implemented to reduce LO pulling, and minimize TX out-of-band spurious in the direct-conversion transmitter. The transmitter provides high output power at +10dBm and +7dBm in BDR and EDR3 modes respectively, with 1.5-kHz frequency stability and <6% RMS DEVM The receiver sensitivity is better than −95.5dBm, −96.5dBm and −89dBm for BDR, EDR2 and EDR3 modes respectively. DC current consumption for continuous TX transmission at +10dBm output power is 48mA, and for continuous RX reception at reference sensitivity level is 35mA. Total die size is 5.7mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , of which 1.8mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is occupied by RF, analog and PMU circuits.
PHOTOCOAGULATION OF HUMAN PLASMA: ACYL SERINE PROTEINASE PHOTOCHEMISTRY (1990)

Human alpha-thrombin or bovine Factor Xa was acylated at the active site serine hydroxyl with alpha-methyl-2-hydroxy-4-diethylaminocinnamic acid. These modified serine proteinase enzymes showed no plasma coagulation biological activity in the absence of light. Photolysis of the acyl serine proteinase enzymes in plasma for 1-35 s with monochromatic 366 nm light isolated from a high pressure mercury arc results in coagulation of the plasma. For example, photolysis of 3 NIH U of the acyl human alpha-thrombin for 5 s in human plasma results in a clot in 23 s. For comparison, 1 NIH U of unmodified human alpha-thrombin gave a clot in 21 s under the conditions of the assay but without photolysis. Appropriate controls showed that the coagulation is the result of the formation of active thrombin due to photodeacylation of the enzymes. The photoinduced clotting time measured is dependent on acyl thrombin concentration and photolysis time. Thus higher concentrations of acyl thrombin and longer photolysis times give a shorter clotting time. A kinetic scheme based upon Lineweaver-Burke analysis of the clotting process is developed.
Add exercise to calcium in osteoporosis prevention (1982)

Dietary calcium supplements can provide valuable aid in slowing age-related bone loss and warding off some of the hazards of osteoporosis. But taking supplements without engaging in physical exercise— preferably of the jogging or walking variety—is like settling for half a loaf. As was agreed at a recent symposium on diet and exercise held in Orlando, Fla, under the auspices of the Florida Medical Association and the American Medical Association, the mechanisms of action of dietary calcium supplementation and physical activity appear to be different. Calcium acts to suppress bone resorption, whereas mechanical stress seems to enhance bone formation. Consequently, combining the two measures appears to be the most practical approach to preserving sound skeletal mass into old age. In one report on the subject, G. Donald Whedon, MD, senior science advisor to the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, told of several studies showing that