gebhart/patrepeval huggingface dataset:
Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells (1999)

To elucidate the possibility of utilizing protein kinase C (PKC) isoforms as target genes in neuroblastoma therapy, 5 neuroblastoma cell lines and neuroblastoma tumor specimens were examined for PKC isoform expression pattern and the cell lines were analyzed for sensitivity to PKC inhibition. All cell lines [IMR-32, LAN-2, LAN-5, SH-SY5Y and SK-N-BE(2)] expressed alpha, betaII, delta and epsilon isoforms of PKC, while no PKCeta or theta protein was detected in any cell line. PKCgamma was found only in LAN-2 cells. PKCalpha, betaII and delta were detected in 5 neuroblastoma tumors and PKCepsilon in 4 out of 5 tumors. Exposure to the PKC inhibitors GF109203X, Gö 6976 or Gö 6983 caused a decrease whereas activation of PKC with 12-O-tetradecanoyl phorbol 13-acetate caused an increase in the number of neuroblastoma cells. The effect of Gö 6976 was due to both inhibited proliferation and to increased apoptosis. While GF109203X suppressed neurite outgrowth induced by a growth factor combination, Gö 6976 potentiated neurite outgrowth. Our data suggest a role for classical PKC isoforms in neuroblastoma growth and survival and for novel isoforms in neurite outgrowth.
Condensed tannins: (4.beta..fwdarw.8;2.beta..fwdarw.O.fwdarw.7)-linked procyanidins in Arachis hypogea L (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCondensed tannins: (4.beta..fwdarw.8;2.beta..fwdarw.O.fwdarw.7)-linked procyanidins in Arachis hypogea LJoseph J. Karchesy and Richard W. HemingwayCite this: J. Agric. Food Chem. 1986, 34, 6, 966–970Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/jf00072a009https://doi.org/10.1021/jf00072a009research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Complexes of heparin with elastomeric positive polyelectrolytes (1971)

Abstract A new elastomeric heparin complex containing from 7 to 16% of heparin was synthesized from commercially available polyether diisocyanates. Chemical analysis and solubility measurements of intermediates as well of the final product showed beyond doubt that an ionic bond was formed between heparin and the quaternized polyether polyurethane. The solubility of the heparin complex in specific solvents systems permitted to cast films or form coatings on commercial plastics. The films and the coatings were found to be non‐thrombogenic and whole human blood could be stored in 1/8 or 3/16″ID coated tubing for at least 24 hr without occurence of clotting. The values of tensile strength, elongation at break and of the shear modulus as a function of temperature showed that the heparinized complexes were endowed with desirable mechanical properties under ambient conditions.
Photonic switching technology (1989)

Abstract I examine the scope for exploiting the properties of free-space and guided-wave interconnects to enhance the performance of synchronous self-routing switching matrices, with application to fast packet or asynchronous time division switching in mind.
The Direct Carbamoylation of Organometallic Reagents with 1,2,3-Benzotriazole -1-carboxamides (1999)

Various (hetero) aromatic amides are synthesized efficiently by the carbamoylation of organometallic reagents.
Fiber-optic interferometric geophone with hydrophone applications (1987)

A fiber-optic interferometric geophone has been developed which consists of a seismic mass (520 g) supported by two rubber mandrels wound with a single layer of single-mode optical fiber. The mandrels act as the springs as shown schematically in Fig. 1. The two mandrel-wound lengths of optical fiber, each 6.5 m long, with reflecting ends are attached to a coupler to form the two legs in a Michelson interferometer. When the case of the sensor is displaced at frequencies above the mass-spring resonance frequency (i.e., in the mass controlled frequency regime), the mass remains approximately at rest, while the fiber around one mandrel is compressed and the other is expanded. This geometry has the advantage of not requiring a reference leg and providing 4 times the sensitivity of a single sensor by its push-pull operation and the fact that the light traverses each leg twice due to reflection. Sensitivities of 7500 rad/μm have been measured at frequencies above the mass-spring resonance.
NONPARALLEL WAVE INSTABILITY ANALYSIS OF BOUNDARY-LAYER FLOWS (1987)

An order-of-magnitude approach is employed to analyze the linear nonparallel wave instability of boundary-layer flows. This analysis removes the restriction imposed by previous investigators on the weak dependence of the streamwise variation of disturbance quantities. A superposition technique along with a modified Thomas trans-formation is employed to solve the resulting nonhomogeneous equation for the amplitude function of the disturbance without the use of an adjoint eigenfunction, which is needed in conventional approaches. All of the eigenfuncrions are treated in their general forms. The growing rate of the disturbance intensity is found to depend on both streamwise and transverse coordinates. At a local observation point × (or Re×), the growing rate of the disturbance intensity has a maximum value near y = Y = Ylpar;U∞/ vX)½ = 3 for Blasiusflow. The neutral stability curve can then be defined by letting the maximum growing rate of the disturbance intensity be zero. Excellent agreement is found between the present results and available experimental data.
Susceptibility of lodgepole pine to infestation by mountain pine beetles following partial cutting of stands (1988)

Thinning stands of lodgepole pine (Pinuscontorta Douglas var. latifolia Engelmann) is thought to increase vigor and thereby reduce susceptibility to mountain pine beetle (Dendroctonusponderosae Hopkins). Partial cut stands of lodgepole in the Kootenai and Lolo National forests, Montana, U.S.A., provided opportunity (i) to determine growth response of 76- to 102-year-old lodgepole pines following thinning and (ii) to test the hypothesis that vigor of residual trees infested and uninfested by beetles does not differ. Lodgepole pine stands receiving different partial cutting prescriptions were sampled. Characteristics measured for trees within the sample were diameter at breast height, grams of stem wood per square metre of foliage, periodic growth ratio, and leaf area. Trees in most treatments showed decreased growth the 1st year following thinning. The 1st year was followed by increased growth during the next 4 years. Of the tree characteristics measured, only dbh was significantly different on both forests between live trees and trees killed by the mountain pine beetle; the latter were larger (P < 0.001). The low amount of mountain pine beetle infestation in all stands in the presence of poor growth response and vigor of residual trees suggests that factors other than tree vigor will regulate mountain pine beetle infestations in recently thinned lodgepole pine stands. We hypothesize change in stand microclimate is the principal factor.
Infrared thermography analysis of thermal diffusion induced by RF magnetic field on agar phantoms loaded with magnetic nanoparticles (2013)

Recently, several treatments for fighting malignant tumors have been designed. However these procedures have well known inconveniences, depending on their applicability, tumor size and side effects, among others. Magnetic hyperthermia is a safe, non-invasive method for cancer therapy. This treatment is applied via elevation of target tissue temperature by dissipation of heat from Magnetic Nanoparticles (MNPs), previously located within the tumor. The induction of heat causes cell death and therefore the removal of the tumor. In this work the thermal diffusion in phantoms of agar loaded with magnetic nanoparticles (MNPs) is studied using the infrared thermography technique, which is widely used in biology/medicine (e.g. skin temperature mapping). Agar is one of the materials used to simulate different types of body tissues, these samples are known as “phantoms”. Agar is of natural origin, low cost and high degree of biocompatibility. In this work the agar gel was embedded with MNPs by coprecipitation and placed in an alternating magnetic field radiation. As a consequence, the energy from the radiation source is dissipated as heat and then transferred from the MNP to the gel, increasing its temperature. For the temperature analysis, the samples of agar gel were stimulated by RF magnetic field generated by coils. Heating was measured with infrared thermography using a Thermovision A20M infrared camera. Thermographic images allowed obtaining the dependence of thermal diffusion in the phantom as a function of the magnitude of the applied RF magnetic field and the load of magnetic particles.
A Highly Automated, Wireless Inertial Measurement Unit Based System for Monitoring Gym-Based Push-Start Training Sessions by Bob-Skeleton Athletes (2015)

Wireless Inertial Measurement Units (WIMUs) are increasingly used to improve our understanding of complex human motion scenarios. In sports this allows for more valid coaching, selection and training methods leading to improved athletic performance. The Push-Start in the Winter Olympic sport of Bob-Skeleton is poorly understood but believed to be critical to performance. At the University of Bath a piece of gym-based equipment called the “Assassin” used by athletes to practice the Push-Start was instrumented with a custom WIMU system to investigate this motion regime. A test subject performed 36 runs, comprising 3 runs at each of 12 combinations of 3 Incline and 4 Weight settings. A developed algorithm automatically identified valid data-files, extracted the Pushing-Phase Acceleration data, and estimated sled Velocity and Displacement. The average velocities derived from an existing Light-Gate and WIMU data-files were comparable, with an average Root Mean Squared Error of 0.105 meters per second over the 52 valid WIMU data-files identified, covering 11 of the 12 Weight and Incline settings. Additional investigation of WIMU data revealed information such as: step count; track incline; and whether weights had been added could be determined, although further verification and validation of these features are required. Such an automated WIMU-based system could replace performance monitoring methods such as Light-Gates, providing higher fidelity performance data, additional information on equipment setup with lower-cost and greater ease-of-use by coaches or athletes. Its portable and modular nature also allow use with other training scenarios or equipment, such as using additional on-body WIMUs, or use with outdoor and ice-track sleds, enabling performance monitoring from the gym to the ice-track for improved candidate selection, comparison and training in Bob-Skeleton and other ice-track based sled sports.
Variable Selection in Multivariate Calibration of a Spectroscopic Glucose Sensor (1997)

A variable selection method that reduces prediction bias in partial least-squares regression models was developed and applied to near-infrared absorbance spectra of glucose in pH buffer and cell culture medium. Comparisons between calibration and prediction capability for full spectra and reduced sets were completed. Variable selection resulted in statistically equivalent errors while reducing the number of wavelengths needed to fit the calibration data and predict concentrations from new spectra. Fewer than 25 wavelengths were selected to produce errors statistically equivalent to those yielded by the full set containing over 500 wavelengths. The algorithm correctly chose the glucose absorption peak areas as the information-carrying spectral regions.
A Critical Review of Randomized Controlled Trials of Static Magnets for Pain Relief (2005)

The weight of evidence from published, well-conducted controlled trials suggests that static magnetic fields are able to induce analgesia.
Galactose-specific lectin from Viscum album as a mediator of aggregation and priming of human platelets. (1995)

Galactose-specific lectin from Viscum album (VAA) was found to induce aggregation of human platelets in a dose- and sugar-dependent manner. Small nonaggregating concentrations of VAA primed the response of platelets to known aggregants (ADP, arachidonic acid, thrombin, ristocetin, and A23187). VAA-induced platelet aggregation was completely reversible by addition of the sugar inhibitor lactose and the platelets from disrupted aggregates maintained the response to other aggregants. The lectin-induced aggregation of washed platelets was more resistant to metabolic inhibitors than thrombin- or arachidonic acid-dependent cell interaction. In contrast to the related galactose-specific lectin from Ricinus communis and the soy bean agglutinin, the lectin did not aggregate liposomes prepared from total platelet lipids, indicating different affinities of aggregation-mediating lectins to platelet glycolipids.
<title>Front end of the high-energy Nd:glass laser fusion system with shaped nanosecond laser pulses</title> (2001)

The design and performance of front end system for the upgrade six-channel Nd:glass laser facility PROGRESS are presented. The system consists of a single-mode Q-switch Nd:YLF master oscillator, pulse shaping system and preamplifier. The pulse shaping system comprises a LiTaO<SUB>3</SUB> electro optic deflector pair driven by high-voltage generators on drift step recovery diodes. The system produces the shaped laser pulses in 1-10 nanosecond duration range. In one-pass preamplifier including a sequence of Nd:glass rod amplifiers with output aperture of 30mm the shaped pulses are amplified up to 5 J energy level.
Nitrogen-Assisted Ortho Lithiation:  One-Pot Synthesis of New Classes of Bidentate and Tetradentate Mixed P∼N Ligands (2006)

Metalation of one aryl group of Ph3PNR (R = methyl, isopropyl) affords an easy access to the corresponding lithium salt, which in turn reacts with chlorophosphines R2PCl (R = Ph, i-Pr) to yield a new class of bidentate ligand featuring one iminophosphorane and one phosphino group. Reaction of the phenyl derivative with [Pd(COD)Cl2] yielded the expected six-membered palladacycle complex, which was structurally characterized. Extension of this new synthetic methodology toward the elaboration of enantiomerically pure tetradentate ligands has also been achieved.
Filibuster : a new Swedish text-to-speech system (2007)

A Swedish text-to-speech system has been developed at the Swedish Library of Talking Books and Braille (TPB). The system, named Filibuster, is open and extensible and makes it possible to generate synthetic speech with a high degree of control. The Filibuster system is used in the production of talking books in TPBs service for print handicapped students at university level. Through the use of text-to-speech, students can receive their talking books much faster. Also, each book costs less to produce. The system was deployed in February 2007 and during this year the plan is to produce a total of 200 titles. The system has been designed specifically for creating talking book versions of university textbooks. It has a large lexicon, covering some 573,000 words and names. Filibuster includes a comprehensive text pre-processor to write out nonword entities, such as numbers, characters and expressions. So far, one male voice, Folke, has been created, but more are planned.
Accurate Pilot-Aided Sampling Frequency Offset Estimation Scheme for DRM Broadcasting Systems (2010)

In this paper, we propose an improved sampling frequency offset (SFO) estimation scheme for orthogonal frequency division multiplexing (OFDM) based digital radio mondiale (DRM) broadcasting systems. To demonstrate the performance of the proposed frequency estimator, analytical expression of the mean square error (MSE) is derived and performances are compared with conventional pilot-assisted estimators. Based on the simulation and theoretical analysis, our proposed estimator shows an improved estimation performance compared to the conventional estimators.
Rapid High-Performance Liquid Chromatographic Assay for Salicylic Acid in Plasma Without Solvent Extraction (1996)

The in vivo measurement of highly reactive free radicals, such as the hydroxyl radical (oOH), in humans is very difficult, if not impossible. Specific markers, based on the ability of oOH to attack aromatic molecules and produce hydroxylated compounds, are under investigation. In vivo radical metabolism of salicylic acid produces two main hydroxylated derivatives: 2,3- and 2,5-dihydroxybenzoic acid (DHBA). The measurement of 2,3-DHBA, following oral administration of salicylic acid or its acetylated form (aspirin), is proposed for the assessment of in vivo oxidative stress. The intensity of oxidative stress is a function of the ratio of dihydroxylated derivatives to salicylic acid rather than the absolute dihydroxylated derivatives levels. Consequently, a simple, accurate, and sensitive assay of the salicylic acid level in plasma is needed to investigate the in vivo free radical production. In this work, a rapid and sensitive method is presented that is useful for the quantitation of salicylic acid in biological fluids. The methodology uses high-performance liquid chromatography with spectrophotometric detection for the identification and quantitation of salicylic acid without organic extraction. A detection limit of less than 5 mumol is achieved with spectrophotometric detector responses that are linear over at least 6 orders of magnitude. Plasma concentrations of salicylic acid determined by the present technique are reported following the administration of 1000 mg aspirin in 20 healthy subjects.
Masking noise in up-scaled video on large displays (2005)

Noise is often annoyingly visible on large flat-screen television sets, particularly if spatially up-converted standard definition material is displayed. We introduce a novel method to reduce the perceived noise that exploits noise masking.
Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16 (2014)

The undecapeptide KKLFKKILKKL-NH2 (BP16) is a non-toxic cell-penetrating peptide (CPP) that is mainly internalized into cancer cells through a clathrin dependent endocytic mechanism and localizes in late endosomes. Moreover, this CPP is able to enhance the cellular uptake of chlorambucil (CLB) improving its cytotoxicity. In this work, we further explored the cell-penetrating properties of BP16 and those of its arginine analogue BP308. We investigated the influence on the cytotoxicity and on the cellular uptake of conjugating CLB at the N- or the C-terminal end of these undecapeptides. The effect of incorporating the cathepsin B-cleavable sequence Gly-Phe-Leu-Gly in CLB-BP16 and CLB-BP308 conjugates was also evaluated. The activity of CLB was significantly improved when conjugated at the N- or the C-terminus of BP16, or at the N-terminus of BP308. While CLB alone was not active (IC50 of 73.7 to >100 μM), the resulting conjugates displayed cytotoxic activity against CAPAN-1, MCF-7, PC-3, 1BR3G and SKMEL-28 cell lines with IC50 values ranging from 8.7 to 25.5 μM. These results were consistent with the internalization properties observed for the corresponding 5(6)-carboxyfluorescein-labeled conjugates. The presence of the tetrapeptide Gly-Phe-Leu-Gly at either the N- or the C-terminus of CLB-BP16 conjugates further increased the efficacy of CLB (IC50 of 3.6 to 16.2 μM), which could be attributed to its selective release in the lysosomal compartment. Enzymatic assays with cathepsin B showed the release of CLB-Gly-OH from these sequences within a short time. Therefore, the combination of BP16 with an enzymatic cleavable sequence can be used as a drug delivery system for the effective uptake and release of drugs in cancer cells.
Precision AC measurements of temperature below 90 K (1989)

Specially designed sealed cells filled with ultrapure gas have been utilized for the realization of thermodynamic fixed points in the Primary Standards Laboratory. Accurate determination of the triple-point temperatures of Ar, N/sub 2/, O/sub 2/, Ne, and D/sub 2/ was accomplished with a high-precision AC resistance bridge operating at a frequency of 30 Hz. Detailed data obtained for platinum resistance thermometers (PRTs) and rhodium-iron (Rh-Fe) sensors are presented. The levels of accuracy and precision achieved are evaluated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Integration of telecom energy systems into network management models using remote intelligent supervision, monitoring, and control (2002)

The integration of telecom energy systems within today's evolving definition of network management systems (NMSs) is discussed, emphasizing the viewpoint of the various generic network management centers (NMCs) in an attempt to determine where telecom energy systems fit into NMSs and the telecommunications management network (TMN). As the levels of key competent network support system (NSS) personnel continue to dwindle, companies are being forced to install mechanized systems to meet today's required performance levels of per capita personnel effectiveness. The author categorizes the evolving staffing levels of NSS personnel, identifies the specialized needs of each user station type, and correlates that information with the design requirements of the evolving mechanized network management systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
A Modeling Approach for the Development of Process Driven Web Applications (2014)

Complex web applications have been developed rapidly as to support complex process and transactional workflows involved in the web domain. Although there are numerous modeling concepts exist in web applications nowadays, new issues raises in modeling approach such as user interactions, interrelated process flow, navigational issues and graphical user interface concerns. In this paper, we present and discuss user interaction diagram, Unified Modeling Language (UML) notation and object-oriented approach for necessity in complex web applications. A proposed model called UEWDM (UML-Extensions Web Design Model) emphasize on the user interaction issues as well as the interrelated process, navigation and graphical user interface. The uniqueness of UEWDM is in the design pattern modeling approaches. At the end of the paper, future works of the design model will be explained and briefly summarized.
Psychosocial Determinants of Relapse in Ulcerative Colitis: A Longitudinal Study (2003)

After controlling for demographic and clinical variables, more recent stressful events were associated with earlier time to relapse. These findings, which support a biopsychosocial model of disease, might help clinicians identify patients who might benefit from more intensive maintenance medical therapy and behavioral medicine interventions to reduce stress and improve coping.