gebhart/patrepeval huggingface dataset:
INCREASED EXPRESSION OF INTERFERON (IFN)-GAMMA TOGETHER WITH IFN-GAMMA RECEPTOR IN THE RHEUMATOID SYNOVIAL MEMBRANE COMPARED WITH SYNOVIUM OF PATIENTS WITH OSTEOARTHRITIS (1996)

Data concerning the presence of T-cell-derived cytokines in the rheumatic joint are conflicting, challenging the hypothesis that rheumatoid arthritis (RA) is a T-cell-mediated disease. In this study synovial tissue specimens of 11 patients with RA and eight patients with osteoarthritis (OA) were stained for interferon-gamma (IFN-gamma) and its receptor. The level of expression of IFN-gamma was compared with that in tissue specimens of delayed-type hypersensitivity (DTH) reactions of the skin and of chronic tonsillitis. Furthermore, the percentage of T-lymphocytes which stained positive for IFN-gamma was determined using double staining techniques. IFN-gamma and its receptor were detected in all patients with RA and in 7/8 and 3/8, respectively, of patients with OA. Expression of IFN-gamma (P<0.02) and IFN-gamma receptor (P<0.01) in synovial tissue of patients with RA was more abundant compared with that in patients with OA. Although IFN-gamma could be detected in RA synovial tissue, the level of expression was less when compared with DTH reactions of the skin and tonsillitis. The percentage of CD3+ cells being positive for IFN-gamma was approximately 1% in RA, whereas in DTH reactions of the skin it was >90% and in tonsillitis approximately 30%. We conclude that the presence of IFN-gamma and its receptor in RA synovial tissue suggests a role for this cytokine in the ongoing immunological reaction of the inflamed joint.
RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations (2013)

Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter baumannii. However, the relative contributions of the three most prevalent pumps, AdeABC, AdeFGH, and AdeIJK, have not been evaluated in clinical settings. We have screened 14 MDR clinical isolates shown to be distinct on the basis of multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE) for the presence and overexpression of the three Ade efflux systems and analyzed the sequences of the regulators AdeRS, a two-component system, for AdeABC and AdeL, a LysR-type regulator, for AdeFGH. Gene adeB was detected in 13 of 14 isolates, and adeG and the intrinsic adeJ gene were detected in all strains. Significant overexpression of adeB was observed in 10 strains, whereas only 7 had moderately increased levels of expression of AdeFGH, and none overexpressed AdeIJK. Thirteen strains had reduced susceptibility to tigecycline, but there was no correlation between tigecycline MICs and the levels of AdeABC expression, suggesting the presence of other mechanisms for tigecycline resistance. No mutations were found in the highly conserved LysR regulator of the nine strains expressing AdeFGH. In contrast, functional mutations were found in conserved domains of AdeRS in all the strains that overexpressed AdeABC with two mutational hot spots, one in AdeS near histidine 149 suggesting convergent evolution and the other in the DNA binding domain of AdeR compatible with horizontal gene transfer. This report outlines the high incidence of AdeABC efflux pump overexpression in MDR A. baumannii as a result of a variety of single mutations in the corresponding two-component regulatory system.
Neutron Diffraction Study on the Low-Temperature Monoclinic Form of CeCu<sub>6</sub> (1986)

The low-temperature form of CeCu 6 has been determined from the Rietveld analysis on high-resolution TOF neutron diffraction data at 65 K. The crystal system is monoclinic with lattice parameters a =0.5080 nm, b =1.0121 nm, c =0.8067 nm and β=91.36°. The space group is P 2 1 / c and the unit cell contains four formula units. The structure is a derivative of the high-temperature orthorhombic form associated with a monoclinic deformation and minor shifts of the atomic positions.
A Comparison of Alternative Risk-Assessment Strategies for Predicting Significant Neonatal Hyperbilirubinemia in Term and Near-Term Infants (2007)

An infant's risk of developing significant hyperbilirubinemia can be simply and accurately assessed by using just the infant's predischarge bilirubin level and gestational age.
Problems (1987)

Bruce Reznick, Jerrold W. Grossman, John P. Hoyt, William P. Wardlaw, Stanley Rabinowitz, M. S. Klamkin, Bjorn Poonen, Martin Feuerman, Luz M. DeAlba, Mike Bolla, Dan Kalman, John O. Bennett, Harvey Schmidt, Jr., J. S. Frame, J. T. Groenman, D. J. Smeenk, Richard E. Pfiefer, William A. Newcomb, Robert E. Shafer, Paul Bracken, Roger B. Nelsen, R. Glenn Powers, Ira Rosenholtz, Mihaly Bencze, Problems, Mathematics Magazine, Vol. 60, No. 1 (Feb., 1987), pp. 39-50
Rabbit antibodies to degraded and intact glycosaminoglycans which are naturally occurring and present in arthritic rabbits. (1985)

Using enzyme-linked immunosorbent assays and radioimmunoassays employing chondroitinase ABC-treated rabbit cartilage proteoglycan, we have shown that approximately one-third of the outbred New Zealand white rabbits we have examined possess naturally occurring antibodies which react with oligosaccharides of hyaluronic acid (independently of chain length) bearing saturated and 4,5-unsaturated glucuronosyl residues at the nonreducing ends. Such antibodies were also found in a similar proportion of rabbits with an experimental inflammatory arthritis. There was a preferential reactions in the majority of sera with unsaturated oligosaccharides of hyaluronic acid. One serum (R64) reacted only with unsaturated oligosaccharides of hyaluronic acid. Sera reacted also with unsaturated (never saturated) oligosaccharides of chondroitin 4-sulfate and with chondroitin 6-sulfate, particularly when chondroitin sulfate oligosaccharides remained bound to a proteoglycan core protein. Reactions were also observed to both unsaturated and saturated oligosaccharides of chondroitin. Some of these sera also reacted with intact hyaluronic acid and chondroitin but never with intact chondroitin sulfate. The antibodies were present in the IgG fraction of four sera studied and in the IgM fraction of one of these sera: they bound through the F(ab')2 region of the molecule. These observations suggest that, in some rabbits, humoral immunity to hyaluronic acid and/or chondroitin sulfate bound to core protein can develop after these reactive glycosaminoglycans have been degraded by eliminases or hydrolases produced by naturally occurring bacteria and rabbit cells, respectively. Immunological studies of proteoglycans and hyaluronic acid treated with eliminases and hydrolases employing rabbit antisera, and possibly those from other species, should be evaluated in the light of these observations.
Copper-Assisted Arylation of 1-Thiosugars: Efficient Route to Triazene Substituted Arylthioglycosides (2003)

Efficient copper mediated arylation of sugar thiols by o-haloaryl triazenes under mild conditions is described. The developed method allows the preparation of symmetrical and unsymmetrical 1,3-bis(glycopyranosylthio)benzene derivatives.
Simple method for the generation of multiple homogeneous field volumes inside the bore of superconducting magnets (2015)

Standard Magnetic Resonance magnets produce a single homogeneous field volume, where the analysis is performed. Nonetheless, several modern applications could benefit from the generation of multiple homogeneous field volumes along the axis and inside the bore of the magnet. In this communication, we propose a straightforward method using a combination of ring structures of permanent magnets in order to cancel the gradient of the stray field in a series of distinct volumes. These concepts were demonstrated numerically on an experimentally measured magnetic field profile. We discuss advantages and limitations of our method and present the key steps required for an experimental validation.
Emulsion stabilized by starch nanocrystals (2012)

Abstract The starch nanocrystals made use of in this study were prepared by sulfuric acid hydrolysis of wx maize starch. The stable oil‐in‐water emulsions of 50 vol% paraffin liquid were prepared by using starch nanocrystals as emulsifier when the weight percentage concentration of starch nanocrystal relative to water was above 0.02 wt%. The size of the droplets decreased with the raising of the concentration of starch nanocrystal. These emulsions were very stable to coalescence over months and the creaming of emulsions decreased with the increasing of starch nanocrystal concentration. The surface tension of starch nanocrystal dispersions was found decreased from 71.7 to 45.8 mN/m when the nanocrystal concentration grew from 0.05 to 3.0 wt%. This indicates that starch nanocrystals are surface active particles. Further tests on the emulsifying ability of supernatant of centrifuged starch nanocrystal dispersions and the emulsion stability at the melting temperature of starch nanocrystals confirmed that the emulsions were indeed stabilized by starch nanocrystals.
Why young dads matter...and how to reach them. (2011)

Most maternity services address themselves squarely to mothers, but evidence suggests that engaging with fathers can be an important way of achieving better outcomes, both for children and their mothers. This article debunks some of the commonly heard myths about young fathers (for example that they are not 'around' or interested in fatherhood), summarises key aspects of their importance and suggests approaches which maternity professionals might find useful when trying to engage with them.
rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. (1990)

rhomboid (rho) belongs to a group of four genes involved in the elaboration of positional information at a ventrolateral level in the Drosophila embryo. Mutations at any of these four loci also lead to a variety of other phenotypes, including reduction in the number of stretch receptor organs (chordotonal organs) in the peripheral nervous system (PNS). We have cloned rho with the aid of a lacZ-bearing P-element inserted into the rho gene. In the early blastoderm stage, a putative rho transcript is expressed in ventrolateral strips corresponding to the domain of activity of the rho gene on the embryonic fate map. Later expression of the transcript correlates with regions of the embryo that are disrupted in rho mutants and includes a cell that may be the precursor for the missing stretch receptor organs. We hypothesize that rho acts very early in differentiation pathways to specify the identities of domains and isolated precursor cells. Sequence analysis suggests that this transcript codes for a trans-membrane protein.
Coverage and Lifetime Optimization of Wireless Sensor Networks with Gaussian Distribution (2008)

A wireless sensor network (WSN) has to maintain a desirable sensing coverage and periodically report sensed data to the administrative center (i.e., base station) and the reporting period may range from months to years. Coverage and lifetime are two paramount problems in a WSN due to constraint of associated battery power. All previous theoretical analysis on the coverage and lifetime is primarily focused on the random uniform distribution of sensors or some specific network scenarios (e.g., a controllable WSN). In this paper, we provide an analytical framework for the coverage and lifetime of a WSN that follows a two-dimensional Gaussian distribution. We also study the coverage and lifetime when the dimensions of Gaussian dispersion (i.e., x, y) admit different Gaussian parameters (i.e., standard deviation, $\sigma_x \neq\sigma_y$). We identify intrinsic properties of coverage/lifetime in terms of Gaussian distribution parameters, which is a fundamental issue in designing a WSN. Following the results obtained, we further determine the sensor deployment strategies for a WSN that could satisfy a predefined coverage and lifetime. Two deployment algorithms are developed based on using our analytical models and are shown to effectively increase the WSN lifetime.
Low dark-current, high gain GaInAs/InP avalanche photodetectors (1981)

High performance inverted-mesa GaInAsP/InP avalanche photodiodes responding out to 1.25 μm have been fabricated. Uniform avalanche gains <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> , of 700 dark-current densities of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3 \times 10^{-6}</tex> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> at <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M = 10</tex> , and an excess noise factor of ∼3 at <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M = 10</tex> have been achieved by placing the p-n junction in the InP and using a new passivation technique. Pulse-response rise times of less than 160 ps, limited by the rise time of the mode-locked Nd:YAG laser pulse, were measured with an avalanche gain of 40.
Kinetic analysis of C49-TiSi2 and C54-TiSi2 formation at rapid thermal annealing rates (1992)

We have used in situ resistance versus temperature measurements to demonstrate that a 60 nm titanium thin film on polycrystalline silicon heated at rates up to 3000 °C/min always forms high-resistivity base-centered orthorhombic C49-TiSi2 before the low-resistivity face-centered orthorhombic C54-TiSi2 phase. Kinetic analysis of the shift in transformation temperatures with heating rate indicates that the activation energies for the formation of C49-TiSi2 and C54-TiSi2 are 2.1±0.2 and 3.8±0.5 eV, respectively, when formed during the same annealing cycle. The higher activation energy of formation of C54-TiSi2 as compared to C49-TiSi2 suggests that under very high heating rates and annealing temperatures, the formation of C49-TiSi2 before C54-TiSi2 might be completely or partially bypassed.
Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor (2007)

<sec><st>Objectives</st> This study was performed to analyse <it>in vitro</it> and <it>in vivo</it> activities of CG400549, a new FabI inhibitor, against clinical isolates of staphylococci. The mode of action of CG400549 and resistance mechanism of <it>Staphylococcus aureus</it> against CG400549 were also investigated by genetic approaches. </sec> <sec><st>Methods</st> <it>In vitro</it> activity of CG400549 was evaluated by the 2-fold agar dilution method as described by the CLSI, and compared with those of oxacillin, erythromycin, ciprofloxacin, sparfloxacin, moxifloxacin, gemifloxacin, vancomycin, linezolid and quinupristin-dalfopristin. <it>In vivo</it> activity of CG400549 was determined against systemic infections in mice. Time–kill curves of CG400549 were analysed at concentrations of 1×, 2× and 4× MIC against <it>S. aureus</it> strains. </sec> <sec><st>Results</st> CG400549 had the lowest MICs among the test compounds against 238 clinical isolates of <it>S</it>. <it>aureus</it> (MIC<inf>90</inf>, 0.25 mg/L) and 51 clinical isolates of coagulase-negative staphylococci (MIC<inf>90</inf>, 1 mg/L). The activity of CG400549 was irrespective of whether the strains were methicillin-susceptible or -resistant. Furthermore, CG400549 was effective by oral or subcutaneous administration against systemic infections in mice. In a time–kill study, CG400549 at concentrations of 1× MIC, 2× MIC and 4× MIC had a bacteriostatic activity during 24 h. A FabI-overexpressing <it>S</it>. <it>aureus</it> strain gave rise to an increase in the MIC of CG400549 compared with the parental strain, while the susceptibilities of the FabI-overexpressing <it>S</it>. <it>aureus</it> strain to the other antibacterial agents such as oxacillin, erythromycin and ciprofloxacin were not affected. This result showed that the mode of action of CG400549 was via inhibition of FabI, which is involved in biosynthesis of fatty acids in bacteria. Study of the resistance mechanism of <it>S</it>. <it>aureus</it> showed that CG400549-resistant mutants of <it>S</it>. <it>aureus</it> had an alteration in FabI at Phe-204 to Leu. </sec> <sec><st>Conclusions</st> CG400549 had potent <it>in vitro</it> and <it>in vivo</it> activity against staphylococci, including methicillin-, ciprofloxacin- and multidrug-resistant staphylococci strains. This compound could be a good candidate for clinical development as a novel anti-MRSA drug. </sec>
The Use of Biomass and Stillage Recycle in Conventional Ethanol Fermentation (1996)

Modifications of the conventional ethanol fermentation process using biomass and stillage recycle were investigated and the advantages of the technique were studied. The biomass recycle method resulted in a reduction in the use of approximately 8% raw material (molasses). The recycle of 15–70% of stillage (dealcoholised) from a previous fermentation was also tested successfully. Generally the results of these experiments revealed 13–47% less water consumption and consequently about 13–47% reduction of stillage volume, which was more economical for further treatments.
Annual Summary of Vital Statistics: 2010–2011 (2013)

The number of births in the United States declined by 1% between 2010 and 2011, to a total of 3 953 593. The general fertility rate also declined by 1% to 63.2 births per 1000 women, the lowest rate ever reported. The total fertility rate was down by 2% in 2011 (to 1894.5 births per 1000 women). The teenage birth rate fell to another historic low in 2011, 31.3 births per 1000 women. Birth rates also declined for women aged 20 to 29 years, but the rates increased for women aged 35 to 39 and 40 to 44 years. The percentage of all births to unmarried women declined slightly to 40.7% in 2011, from 40.8% in 2010. In 2011, the cesarean delivery rate was unchanged from 2010 at 32.8%. The preterm birth rate declined for the fifth straight year in 2011 to 11.72%; the low birth weight rate declined slightly to 8.10%. The infant mortality rate was 6.05 infant deaths per 1000 live births in 2011, which was not significantly lower than the rate of 6.15 deaths in 2010. Life expectancy at birth was 78.7 years in 2011, which was unchanged from 2010. Crude death rates for children aged 1 to 19 years did not change significantly between 2010 and 2011. Unintentional injuries and homicide were the first and second leading causes of death, respectively, in this age group. These 2 causes of death jointly accounted for 47.0% of all deaths of children and adolescents in 2011.
Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexesSusumu. Honda, Yoshikazu. Matsuda, Masaye. Takahashi, Kazuaki. Kakehi, and Shigetake. GannoCite this: Anal. Chem. 1980, 52, 7, 1079–1082Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/ac50057a019https://doi.org/10.1021/ac50057a019research-articleACS PublicationsRequest reuse permissionsArticle Views540Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Disseminated Bacille Calmette-Guerin Infection in an AIDS Patient 30 Years after BCG Vaccination (1990)

Journal Article Disseminated Bacille Calmette-Guérin Infection in an AIDS Patient 30 Years after BCG Vaccination Get access Christine Armbruster, Christine Armbruster II. Medical Department, Pulmologisches ZentrumlVienna, and Gesundheitsamt, Institut für Umweltmedizin, Vienna, Austria Reprints or correspondence: Dr. Christine Armbruster, II. Medical Department, Pulmologisches Zentrum/Vienna, SanatoriumstraBe 2, A-1145 Vienna, Austria. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Junker, W. Junker II. Medical Department, Pulmologisches ZentrumlVienna, and Gesundheitsamt, Institut für Umweltmedizin, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Vetter, N. Vetter II. Medical Department, Pulmologisches ZentrumlVienna, and Gesundheitsamt, Institut für Umweltmedizin, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar Gertrude Jaksch Gertrude Jaksch II. Medical Department, Pulmologisches ZentrumlVienna, and Gesundheitsamt, Institut für Umweltmedizin, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 162, Issue 5, November 1990, Page 1216, https://doi.org/10.1093/infdis/162.5.1216 Published: 01 November 1990
Adaptive color image enhancement based geometric mean filter (2011)

In this paper, an adaptive color image enhancement based on geometric mean filter is proposed. The contrast of the color image is enhanced by using saturation feedback from saturation components and incorporating spatial information into luminance components. Hue is preserved in order to avoid color distortion. The adaptive luminance enhancement is achieved by using a geometric mean filter in place of arithmetic mean filter since arithmetic mean filter tends to lose image detail such as edges and sharpness when compared to geometric mean filter. The traditional algorithm uses the arithmetic mean filter which smoothes local variations of luminance and saturation. The reconstructed quality of image using this scheme is generally not satisfactory. In the proposed method, geometric mean filter has been adopted that achieves very good quality reconstructed images, far better than that possible with the arithmetic mean filter. It not only enhances poor quality images but also solves the problem of gray world violation. The experimental results show that color images enhanced by this algorithm are clearer, vivid and efficient.
Toward 2 <sup> <i>W</i> </sup> , beyond web 2.0 (2009)

2 W is a result of the exponentially growing Web building on itself to move from a Web of content to a Web of applications.
Mono‐iodoacetate‐induced experimental osteoarthritis. A dose‐response study of loss of mobility, morphology, and biochemistry (1997)

When a sufficient dose of MIA is used, this model can easily and quickly reproduce OA-like lesions and functional impairment in rats, similar to that observed in human disease. These parameters, as well as proteoglycan metabolism, could serve as indicators for studying chondroprotective drugs, or for evaluating the ability of imaging techniques to detect and evaluate chondral lesions.