gebhart/patrepeval huggingface dataset:
EBSD Observation for Reversible Behavior of Deformation Twins in AZ31B Magnesium Alloy (2009)

A bending device used for SEM-EBSD systems has been developed by the authors, which enables one to intermittently observe changes in microstructures induced by deformation in the same viewing area. Alternate compression-tension loading was applied to a sheet specimen of AZ31B magnesium alloy by bending the specimen. Twins were formed by compression straining. They remained after un-loading. Applying tensile straining lead to the disappearance of all the twins. Most of twins were those of {10\\bar12} types. Anisotropy in mechanical properties of magnesium alloys would be affected by this twinning and de-twinning behaviors.
Assessing "Discover Mojave" Instrument Development and Analysis (2005)

We developed a comprehensive assessment plan and tested the curriculum to determine whether hands-on outdoor recreation events promote knowledge, attitudes, and performance among at-risk urban children. Knowledge, attitude, and performance assessments were developed, refined and conducted through various stages based on cultural and language barriers as well a variety of age groups participating within the events. Findings revealed that knowledge, attitudes, and performance increased substantially as a result of participating in the outdoor recreation events. We conclude that the implementation and assessment of the program is strong. We also make several recommendations for future programs.
ActionScript : The Definitive Guide (2001)

From the Publisher:
ActionScript: The Definitive Guide is for web developers and web authors who want to go beyond simple Flash animations to create enhanced Flash-driven sites. Regardless of your level of programming expertise, this combination of ActionScript fundamentals, applications, and handy quick-reference will have you scripting like a pro.
Classification of malicious web code by machine learning (2011)

Web applications make life more convenient through on the activities. Many web applications have several kind of user input (e.g. personal information, a user's comment of commercial goods, etc.) for the activities. However, there are various vulnerabilities in input functions of web applications. It is possible to try malicious actions using free accessibility of the web applications. The attacks by exploitation of these input vulnerabilities enable to be performed by injecting malicious web code; it enables one to perform various illegal actions, such as SQL Injection Attacks (SQLIAs) and Cross Site Scripting (XSS). These actions come down to theft, replacing personal information, or phishing. Many solutions have devised for the malicious web code, such as AMNESIA [1] and SQL Check [2], etc. The methods use parser for the code, and limited to fixed and very small patterns, and are difficult to adapt to variations. Machine learning method can give leverage to cover far broader range of malicious web code and is easy to adapt to variations and changes. Therefore, we suggests adaptable classification of malicious web code by machine learning approach such as Support Vector Machine (SVM) [3], Naïve-Bayes [4], and k-Nearest Neighbor Algorithm [5] for detecting the exploitation user inputs.
Comparative Genome Sequence Analysis of Multidrug-Resistant <i>Acinetobacter baumannii</i> (2008)

The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii has raised concern in health care settings worldwide. In order to understand the repertoire of resistance determinants and their organization and origins, we compared the genome sequences of three MDR and three drug-susceptible A. baumannii isolates. The entire MDR phenotype can be explained by the acquisition of discrete resistance determinants distributed throughout the genome. A comparison of closely related MDR and drug-susceptible isolates suggests that drug efflux may be a less significant contributor to resistance to certain classes of antibiotics than inactivation enzymes are. A resistance island with a variable composition of resistance determinants interspersed with transposons, integrons, and other mobile genetic elements is a significant but not universal contributor to the MDR phenotype. Four hundred seventy-five genes are shared among all six clinical isolates but absent from the related environmental species Acinetobacter baylyi ADP1. These genes are enriched for transcription factors and transporters and suggest physiological features of A. baumannii that are related to adaptation for growth in association with humans.
Methotrexate: Suppression of Experimental Allergic Encephalomyelitis (1963)

Methotrexate inhibited the production of allergic encephalomyelitis in guinea pigs when administered between the time of sensitization and the onset of disease. If treatment was delayed until the day of onset of encephalomyelitis, the disease was still suppressed and the death rate was reduced. The protective effect of methotrexate was reversed by folinic acid.
Homogeneous Label-Free Genotyping of Single Nucleotide Polymorphism Using Ligation-Mediated Strand Displacement Amplification with DNAzyme-Based Chemiluminescence Detection (2011)

Genotyping of single nucleotide polymorphisms (SNPs) is a central challenge in disease diagnostics and personalized medicine. A novel label-free homogeneous SNP genotyping technique is developed on the basis of ligation-mediated strand displacement amplification (SDA) with DNAzyme-based chemiluminescence detection. Discrimination of single-base mismatches is first accomplished using DNA ligase to generate a ligation product between a discriminant probe and a common probe. The ligated product then initiates two consecutive SDA reactions to produce a great abundance of aptamer sequences against hemin, which can be probed by chemiluminscence detection. The developed strategy is demonstrated using a model SNP target of cytochrome P450 monooxygenase CYP2C19*2, a molecular marker for personalized medicines. The results reveal that the developed technique displays superb selectivity in discriminating single-base mismatches, very low detection limit as low as 0.1 fM, a wide dynamic range from 1 fM to 1 nM, and a high signal-to-background ratio of 150. Due to its label-free, homogeneous, and chemiluminescence-based detection format, this technique can be greatly robust, cost-efficient, readily automated, and scalable for parallel assays of hundreds of samples. The developed genotyping strategy might provide a robust, highly sensitive, and specific genotyping platform for genetic analysis and molecular diagnostics.
Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C (2004)

Ingenol 3-angelate (I3A) is one of the active ingredients in Euphorbia peplus, which has been used in traditional medicine. Here, we report the initial characterization of I3A as a protein kinase C (PKC) ligand. I3A bound to PKC-alpha in the presence of phosphatidylserine with high affinity; however, under these assay conditions, little PKC isoform selectivity was observed. PKC isoforms did show different sensitivity and selectivity for down-regulation by I3A and phorbol 12-myristate 13-acetate (PMA) in WEHI-231, HOP-92, and Colo-205 cells. In all of the three cell types, I3A inhibited cell proliferation with somewhat lower potency than did PMA. In intact CHO-K1 cells, I3A was able to translocate different green fluorescent protein-tagged PKC isoforms, visualized by confocal microscopy, with equal or higher potency than PMA. PKC-delta in particular showed a different pattern of translocation in response to I3A and PMA. I3A induced a higher level of secretion of the inflammatory cytokine interleukin 6 compared with PMA in the WEHI-231 cells and displayed a marked biphasic dose-response curve for the induction. I3A was unable to cause the same extent of association of the C1b domain of PKC-delta with lipids, compared with PMA or the physiological regulator diacylglycerol, and was able to partially block the association induced by these agents, measured by surface plasmon resonance. The in vitro kinase activity of PKC-alpha induced by I3A was lower than that induced by PMA. The novel pattern of behavior of I3A makes it of great interest for further evaluation.
Biological warfare and bioterrorism (2002)

Since the terrorist attack on the United States in September 2001 attention has been focused on the threat of biological warfare. The disruptive effects of deliberate release of anthrax in civilian settings have been well documented, and several other pathogens could also be used as biological weapons. We have described the key features of such pathogens, how they might be used in biological warfare, and the clinical syndromes they cause. We also discuss the medical and logistic response to their possible use.
Mesenchymal stem cell transformation and sarcoma genesis (2013)

MSCs are hypothesized to potentially give rise to sarcomas after transformation and therefore serve as a good model to study sarcomagenesis. Both spontaneous and induced transformation of MSCs have been reported, however, spontaneous transformation has only been convincingly shown in mouse MSCs while induced transformation has been demonstrated in both mouse and human MSCs. Transformed MSCs of both species can give rise to pleomorphic sarcomas after transplantation into mice, indicating the potential MSC origin of so-called non-translocation induced sarcomas. Comparison of expression profiles and differentiation capacities between MSCs and sarcoma cells further supports this. Deregulation of P53- Retinoblastoma-, PI3K-AKT-and MAPK pathways has been implicated in transformation of MSCs. MSCs have also been indicated as cell of origin in several types of chromosomal translocation associated sarcomas. In mouse models the generated sarcoma type depends on amongst others the tissue origin of the MSCs, the targeted pathways and genes and the differentiation commitment status of MSCs. While some insights are glowing, it is clear that more studies are needed to thoroughly understand the molecular mechanism of sarcomagenesis from MSCs and mechanisms determining the sarcoma type, which will potentially give directions for targeted therapies.
Quasi‐Linear Geostatistical Theory for Inversing (1995)

A quasi‐linear theory is presented for the geostatistical solution to the inverse problem. The archetypal problem is to estimate the log transmissivity function from observations of head and log transmissivity at selected locations. The unknown is parameterized as a realization of a random field, and the estimation problem is solved in two phases: structural analysis, where the random field is characterized, followed by estimation of the log transmissivity conditional on all observations. The proposed method generalizes the linear approach of Kitanidis and Vomvoris (1983). The generalized method is superior to the linear method in cases of large contrast in formation properties but informative measurements, i.e., there are enough observations that the variance of estimation error of the log transmissivity is small. The methodology deals rigorously with unknown drift coefficients and yields estimates of covariance parameters that are unbiased and grid independent. The applicability of the methodology is demonstrated through an example that includes structural analysis, determination of best estimates, and conditional simulations.
Regulation of xanthine dehydrogenase and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. (1992)

The central importance of xanthine dehydrogenase (XDH) and xanthine oxidase (XO) in the pathobiochemistry of a number of clinical disorders underscores the need for a comprehensive understanding of the regulation of their expression. This study was undertaken to examine the effects of cytokines on XDH/XO activity and gene expression in pulmonary endothelial cells. The results indicate that IFN-gamma is a potent inducer of XDH/XO activity in rat lung endothelial cells derived from both the microvasculature (LMVC) and the pulmonary artery. In contrast, interferon-alpha/beta, tumor necrosis factor-alpha, interleukin-1 or -6, lipopolysaccharide and phorbol myristate acetate have no demonstrable effect. The increase in XDH/XO activity requires new protein synthesis. By Northern analysis, IFN-gamma markedly increases the level of the 5.0-kb XDH/XO mRNA in LMVC. The increase is due, in part, to increased transcription rate of the XDH/XO gene. Transcriptional activation does not require new protein synthesis. The physiologic relevance of these observations was evaluated by administering IFN-gamma to rats. Intraperitoneal administration leads to an increased XDH/XO activity and XDH/XO mRNA level in rat lungs. In sum, IFN-gamma is a potent and biologically relevant inducer of XDH/XO expression; the major site of upregulation occurs at the transcriptional level.
A low cobalt ternary Cr-Co-Fe alloy for telephone receiver magnet use (1980)

The processing, structure, and properties of a low-cobalt, ternary Fe-28Cr-10.5Co isotropic magnet alloy (Chromindur II), developed for use in the telephone receiver, are described. The new alloy is easy to process, and permits a convenient low-temperature recrystallization anneal of heavily cold rolled strips leading to a fine-grained, ductile, single-phase structure suitable for cold forming into the desired magnet shape prior to aging. Optimization of the microstructural control process during spinodal decomposition is discussed with a particular emphasis on solving the problem of critical control during aging required for desirable magnetic properties. It is shown that, in order to reproducibly achieve an optimum combination of wavelength and amplitude during decomposition, two drastically different continuous cooling curves, connected at some intermediate temperature, must exist. This newly devised, two-stage aging technique permits a reasonably wide heat treating window, and accomodates heat-to-heat compositional variations. Satisfactory isotropic magnet properties are reproducibly obtained by industrial heat treatment leading to a successful commercial application of the new alloy in the ring armature type telephone receiver.
Automatic Parking Space Detection and Tracking for Underground and Indoor Environments (2016)

Even though many public parking lots are located underground and indoors, most existing automatic parking space detection and tracking methods have difficulty handling such scenarios due to severe illumination and complex obstacle conditions. To overcome this problem, this paper proposes a method that detects and tracks parking spaces in underground and indoor environments by fusing sensors already mounted on mass produced vehicles. The proposed detection method finds parking spaces based on a high-level fusion of two complementary approaches: parking slot marking-based and free space-based. Parking slots are detected by estimating parallel line pairs and free spaces are detected by recognizing the positions of parked vehicles as well as pillars. The proposed tracking method enhances the previous method by considering pillar information. Since pillars degrade parking slot tracking performance, this method estimates a pillar region and utilizes it to remove false edges and to estimate the amount of occlusion.
Suppression of reverse short channel effect by a buried carbon layer (2002)

Transient diffusion in epitaxial silicon can be suppressed by incorporating high concentrations of carbon. However, the presence of carbon at this level inside the depletion regions of a device leads to increased leakage. We show that a carbon profile tailored to give reduction of transient diffusion (TED) while minimizing carbon concentration in the depletion layer avoids the problems associated with carbon while maintaining the advantages. Such a profile can be achieved by ion implantation. Before C is able to reduce TED a high temperature annealing step is required that removes the C-implant damage. SIMS measurements verify that the expected reduction in transient diffusion occurred, while NMOS devices fabricated with a buried carbon layer have no RSCE and a shift in threshold voltage indicating suppression of TED. The impact on device leakage is minimal.
Postoperative care in cataract surgery (2012)

Key practices such as restrictions on activities, prophylactic regimens against infection and inflammation, appropriate follow-up with adjustments for individual risk factors and management of complications, and continuing care until visual rehabilitation is complete are advised to optimize visual outcome for patients after cataract surgery.
Innovation and discovery: The application of nucleic acid-based technology to avian virus detection and characterization (2001)

Polymerase chain reaction (PCR)-based approaches to the detection, differentiation and characterization of avian pathogens continue to be developed and refined. The PCRs, or reverse transcriptase-PCRs, may be general, designed to detect all or most variants of a pathogen, or to be serotype, genotype or pathotype specific. Progress is being made with respect to making nucleic acid approaches more suitable for use in diagnostic laboratories. Robotic workstations are now available for extraction of nucleic acid from many samples in a short time, for routine diagnosis. Following general PCR, the DNA products are commonly analyzed by restriction endonuclease mapping (restriction fragment length polymorphism), using a small number of restriction endonucleases, based on a large body of sequence data. Increasingly, however, nucleotide sequencing is being used to analyze the DNA product, in part due to the expanding use of non-radioactive sequencing methods that are safe and enable high throughout. In this review, I highlight some recent developments with many avian viruses: Newcastle disease virus; circoviruses in canary and pigeon; infectious bursal disease virus (Gumboro disease virus); avian adenoviruses, including Angara disease/infectious hydropericardium virus, haemorrhagic enteritis virus of turkeys, and egg drop syndrome virus; avian herpesviruses, including infectious laryngotracheitis virus, duck plague virus, psittacine herpesvirus (Pacheco's parrot disease virus), Marek's disease virus and herpesvirus of turkeys; avian leukosis virus (associated with lymphoid leukosis or myeloid leukosis, and egg transmission); avian pneumoviruses (turkey rhinotracheitis virus); avian coronaviruses, including infectious bronchitis virus, turkey coronavirus and pheasant coronavirus; astrovirus, in the context of poult enteritis and mortality syndrome, and avian nephritis virus; and avian encephalomyelitis virus, a picornavirus related to hepatitis A virus.
Distinctions among pathogenic human mycoplasmas. (1984)

Cytadsorption by Mycoplasma pneumoniae requires dense clustering of the surface membrane protein, P1, at the extreme end of the mycoplasma tip-like organelle. M. pneumoniae mutants incapable of cytadsorption either lack P1 or cannot mobilize and cluster P1 at the terminus. Specific cytadsorption-associated proteins in addition to P1 have been shown by mutant and revertant analysis to be essential for cytadsorption. Using monoclonal antibody probes and surface iodination techniques, additional chemical differences were observed between wild-type and mutant M. pneumoniae. M. genitalium, the recently identified new species, possesses structural and antigenic properties that appear similar to M. pneumoniae. Studies were initiated to establish the relatedness between M. pneumoniae and M. genitalium in terms of cytadsorption and membrane proteins.
Potential of information-centric wireless sensor and actor networking (2013)

In this article, we introduce the application field, challenges, and concept of information-centric networking (ICN) approach as a fundamental driver for wireless sensor and actor networks (WSANs). The similar concepts of Internet-based ICN are explored in WSAN, but we introduce a new scheme and purpose which are totally different from Internet-ICN. The exploration introduces new capabilities of the ICN approach for WSANs: efficient coordination, interoperability, service discovery, and prioritized routing. This exploration establishes a potential foundation to improve performance of WSANs while opening new avenues for future research in the information-centric Internet of Things.
Licit: Administering Usage Licenses in Federated Environments (2013)

We address the problem of usage license administration in federated settings. This problem arises whenever organizations, such as educational or research groups or institutions, share resources for business and scientific reasons. In such settings, each user's usage of a licensed resource is typically supported by the user's organization. License administration involves satisfying legal requirements while applying organizational strategies for effective resource usage, and carrying out suitable accounting and audit controls. We propose an approach, Licit, wherein an agent represents each resource sharing site and administers licenses in collaboration with other agents. We show how to represent a variety of usage licenses formally as executable policies and provide a simple information model using which each party can specify both the attributes involved in its licenses and how to resolve them. Our architecture naturally accommodates a variety of site-specific (i.e., custom) strategies for license administration. Licit has been implemented in a popular open source framework for virtual computing, and yields performance results indicating its practical feasibility.
The Enzymatic Acetylation of Chloramphenicol by Extracts of R Factor-resistant Escherichia coli (1967)

Chloramphenicol-resistant strains of Escherichia coli which carry the episomal resistance transfer factor R inactivate the antibiotic by enzymatic acetylation. In the presence of chloramphenicol and acetyl coenzyme A, cell extracts catalyze the formation of both a monoacetyl and a diacetyl derivative of chloramphenicol. Definitive identification of the reaction products as 3-acetoxy chloramphenicol and 1,3-diacetoxy chloramphenicol was possible with the use of thin layer chromatography and ultraviolet spectroscopy. A simple spectrophotometric assay of acetylation has been devised based on the disappearance of acetyl coenzyme A. Preliminary kinetic data for the acetylation of chloramphenicol and related compounds are presented.
Quantum bound states in a double-bend quantum channel (1995)

By use of the mode-matching technique the quantum bound states in a double-bend quantum channel of finite length connecting to two 2D electron gas reservoirs have been investigated in detail. The conductance G of the quantum system is calculated as a function of Fermi energy and the electron density associated with bound states. It is found that there exists one resonant peak in G corresponding to resonant tunneling via one quasibound state below the first conductance plateau for the quantum channel with double-bend continuity and two resonant peaks in G corresponding to resonant tunneling via two quasibound states which are symmetric and antisymmetric superposition of two local bound states localized at two right-angle bends below the first conductance plateau for the quantum channel with double-bend discontinuity. At finite temperature the results are compared with experimental results and are found to explain them well.