gebhart/patrepeval huggingface dataset:
Interplay of Electrostatic and Hydrophobic Effects with Binding of Cationic Gemini Surfactants and a Conjugated Polyanion:  Experimental and Molecular Modeling Studies (2007)

Understanding factors responsible for the fluorescence behavior of conjugated polyelectrolytes and modulation of their behavior are important for their application as functional materials. The interaction between the anionic poly{1,4-phenylene-[9,9-bis(4-phenoxy-butylsulfonate)]fluorene-2,7-diyl}copolymer (PBS-PFP) and cationic gemini surfactants alpha,omega-(CmH2m+1N+(CH3)2)2(CH2)s(Br-)2 (m-s-m; m=12, s=2, 3, 5, 6, 10, and 12) has been studied experimentally in aqueous solution. These surfactants are chosen to see whether molecular recognition and self-assembly occurs between the oppositely charged conjugated polyelectrolyte and gemini surfactant when the spacer length on the surfactant is similar to the intercharge separation on the polymer. Without surfactants, PBS-PFP exists as aggregates. These are broken up upon addition of gemini surfactants. However, as anticipated, the behavior strongly depends upon spacer length (s). Fluorescence measurements show three surfactant concentration regimes: At low concentrations (<2x10(-6) M) quenching occurs and is most marked with the small spacer 12-2-12; at intermediate concentrations (approximately 2x10(-6)-10(-3) M), fluorescence intensity is constant, with a 12-carbon spacer 12-12-12 showing the strongest fluorescence; above the critical micelle concentration (CMC; approximately 10(-3) M) increases in emission intensity are seen in all cases and are largest with the intermediate spacers 12-5-12 and 12-6-12, where the spacer length most closely matches the distance between monomer units on the polymer. With longer spacer length surfactants, surface tension measurements for concentrations below the CMC reveal the presence of polymer-surfactant aggregates at the air-water interface, possibly reflecting increased hydrophobicity. Above the CMC, small-angle neutron scattering experiments for the 12-6-12 system show the presence of spherical aggregates, both for the pure surfactant and for polyelectrolyte/gemini mixtures. Molecular dynamics simulations help rationalize these observations and show that there is a very fine balance between electrostatic and hydrophobic interactions. With the shortest spacer 12-2-12, Coulombic interactions are dominant, while for the longest spacer 12-12-12 the driving force involves hydrophobic interactions. Qualitatively, with the intermediate 12-5-12 and 12-6-12 systems, the optimum balance is observed between Coulombic and hydrophobic interactions, explaining their strong fluorescence enhancement.
Service Supply and Customer Satisfaction in Public Transportation: The Quality Paradox (2009)

Satisfaction measures obtained from citizens are frequently used in performancebased contracts due to their presumed link with company performance. However, few studies have actually examined the link between traveler satisfaction measures and objective performance measures in public transport. This research analyzes the relationship between the objective performance measures of public transport services and the satisfaction perceived by travelers. Data were collected in six different European cities. Three objective service performance measures were obtained for each city from the UITP Millennium Database. Three subjective satisfaction attribute measures were obtained from Benchmarking in European Service of Public Transport (BEST 2001), answered by 6,021 respondents in total. In addition to subjective attribute measures, overall satisfaction was also used as a subjective measure. Several correlational analyses show that the relationship between satisfaction and service performance in public transport is far from perfect.
Similarity of Synthetic Peptide from Human Tumor to Parathyroid Hormone in Vivo and in Vitro (1987)

One mechanism considered responsible for the hypercalcemia that frequently accompanies malignancy is secretion by the tumor of a circulating factor that alters calcium metabolism. The structure of a tumor-secreted peptide was recently determined and found to be partially homologous to parathyroid hormone (PTH). The amino-terminal 1-34 region of the factor was synthesized and evaluated biologically. In vivo it produced hypercalcemia, acted on bone and kidney, and stimulated 1,25-dihydroxy-vitamin D3 formation. In vitro it interacted with PTH receptors and, in some systems, was more potent than PTH. These studies support a long-standing hypothesis regarding pathogenesis of malignancy-associated hypercalcemia.
Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole <scp>l</scp> -Riboside 1263W94 (2001)

The average 50% inhibitory concentration (IC(50)) values for AD169 were 0.22 +/- 0.09 microM 1263W94 and 5.36 +/- 0.12 microM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC(50) was 0.42 +/- 0.09 microM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC(50) was 3.78 +/- 1.62 microM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.
SKI-606 (Bosutinib) Blocks Prostate Cancer Invasion, Growth, and Metastasis <i>In vitro</i> and <i>In vivo</i> through Regulation of Genes Involved in Cancer Growth and Skeletal Metastasis (2010)

In the current study, we have examined the efficacy of a Src/Abl kinase inhibitor SKI-606 (Bosutinib) for its effect on prostate cancer growth and skeletal metastasis. Treatment of highly invasive human prostate cancer cells PC-3 and DU-145 with different doses of SKI-606 decreased Src activation, cell proliferation, migration, and invasion as determined by Matrigel Boyden chamber invasion assay. For in vivo studies, PC-3 cells were inoculated through s.c. or i.t. route into male BALB/c nu/nu or Fox Chase severe combined immunodeficient mice, respectively. Experimental animals treated with SKI-606 developed tumors of a significantly smaller volume and a significant decrease (50%) in experimental skeletal lesion area. A marked increase (32%) in bone volume to tumor volume ratio was also seen by micro-computed tomography analysis of tibias from control and experimental groups of animals. Western blot analysis showed the ability of SKI-606 to significantly decrease the phosphorylation of signaling molecules (AKT, mitogen-activated protein kinase, focal adhesion kinase) and the expression of tumor progression-associated genes uPAR, MMP-2, MMP-9, N-cadherin, fibronectin, BMP-2 (bone morphogenetic protein 2), BMP-6 (bone morphogenetic protein 6), IL-8 (interleukin 8), and TGF-beta (transforming growth factor beta) in prostate cancer cells. SKI-606 is currently in clinical trials for breast cancer and chronic myelogenous leukemia. Results from these studies provide convincing evidence for evaluating its efficacy in prostate cancer patients.
Enhanced toughness and shape memory behaviors of toughed epoxy resin (2012)

This paper reports on an approach to enhance the toughness of shape memory epoxy by using polypropylene glycol diglycidyl ether (G) as the toughening agent. The mechanical properties and shape memory behavior of the toughened resin systems with different loading level of G were studied, respectively. Results of the torsional braid analysis (TBA) test indicated that G had good compatibility with the epoxy resin matrix and induced a decrease in the glass transition temperature, T g , of the toughened systems when compared to that of the neat resin system; and the decrease in T g scaled with the content of G added in the system. Impact strength tests showed that the impact strength was improved significantly by adding G into the resin system and it increased by a factor of 13.7 for the system with 13 wt.% content of G. In addition, the toughened systems were found to yield during the impact strength test whereas brittle fracture occurred for the neat epoxy resin system; this behavior could be further confirmed by the results of scanning electron microscopy (SEM). In the shape memory behavior tests, strain fixity ratio reached as high as 98.9% for toughened systems with 7, 9, 11, 13, and 15 wt.% of G. Toughened systems also displayed changed shape recovery behavior that was comparable with that of the neat epoxy resin system during shape memory process.
A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies (2013)

This is the first report, to date, examining the individual pharmacokinetics of various polymyxin B components in mice. Our results revealed no considerable differences in clearances among the components. The limited exposure of polymyxin B in ELF observed was consistent with the less favourable efficacy of polymyxin B reported for the treatment of pulmonary infections. This method can be used to further examine the pharmacokinetics of polymyxin B in a variety of clinical and experimental settings.
High current density carbon nanotube FEAs grown by DC plasma CVD (2006)

High currents from carbon nanotubes grown inside arrays of gated silicon posts are measured using a DC plasma CVD reactor. The arrays occupying /spl sim/0.1 mm/sup 2/ area typically delivered at least 100 /spl mu/A total current to an anode, with similar currents intercepted by the gate. Currents in excess of 100 /spl mu/A could be sustained for many hours with short term fluctuations below 1%. Several arrays delivered roughly 1 mA. The highest currents (equivalent to 1 A/cm/sup 2/) occurred at gate potentials near 60 V, giving transconductance values exceeding 100 /spl mu/S or 100 mS/cm/sup 2/.
Neural Network Dynamics for Model-Based Deep Reinforcement Learning with Model-Free Fine-Tuning (2018)

Model-free deep reinforcement learning algorithms have been shown to be capable of learning a wide range of robotic skills, but typically require a very large number of samples to achieve good performance. Model-based algorithms, in principle, can provide for much more efficient learning, but have proven difficult to extend to expressive, high-capacity models such as deep neural networks. In this work, we demonstrate that neural network dynamics models can in fact be combined with model predictive control (MPC) to achieve excellent sample complexity in a model-based reinforcement learning algorithm, producing stable and plausible gaits that accomplish various complex locomotion tasks. We further propose using deep neural network dynamics models to initialize a model-free learner, in order to combine the sample efficiency of model-based approaches with the high task-specific performance of model-free methods. We empirically demonstrate on MuJoCo locomotion tasks that our pure model-based approach trained on just random action data can follow arbitrary trajectories with excellent sample efficiency, and that our hybrid algorithm can accelerate model-free learning on high-speed benchmark tasks, achieving sample efficiency gains of 3-5× on swimmer, cheetah, hopper, and ant agents. Videos can be found at https://sites.google.com/view/mbmf.
Exploring Search Engine Optimization (SEO) Techniques for Dynamic Websites (2011)

ABSTRACT Context: With growing number of online businesses, Search Engine Optimization (SEO) has become vital to capitalize a business because SEO is key factor for marketing an online business. SEO is the process to optimize a website so that it ranks well on Search Engine Result Pages (SERPs). Dynamic websites are commonly used for e-commerce because they are easier to update and expand; however they are subjected to indexing related problems. Objectives: This research aims to examine and address dynamic websites indexing related issues. To achieve aims and objectives of this research I intend to explore dynamic websites indexing considerations, investigate SEO tools to carry SEO campaign in three major search engines (Google, Yahoo and Bing), experiment SEO techniques, and determine to what extent dynamic websites can be made search engine friendly on these major search engines. Methods: In this research, detailed literature survey is performed to evaluate existing knowledge for SEO for dynamic websites. Further empirical experiments are conducted to address dynamic websites indexing problems; and to evaluate SEO techniques used in empirical experiments. Results: It is found that all major search engines, including Google, cannot fully index dynamic websites. I used some SEO techniques which I explored during this study to help dynamic webpage(s) get indexed in major search engines. The experiment results reflect the effectiveness of SEO techniques including URL encoding /friendly URLs on major search engines. Conclusions: I conclude that, dynamic websites are subjected to indexing related problems and require additional SEO efforts to appear in SERPs. Not all SEO techniques are equally effective on all search engines to improve indexing of dynamic webpage(s). Each implemented SEO technique has different impression on major search engines (Google, Yahoo, Bing, Ask, and AOL). As, the encoded URLs technique is effective on all major search engines. However, Yahoo and Bing prefer friendly URLs over typical URLs with parameters. Therefore, presentation of dynamic URL could be quite paying if it is needed to index dynamic website on search engines other than Google.
Gangliosides determine the amyloid pathology of Alzheimer's disease (2009)

Gangliosides, GM3 and GM1, are suggested to accelerate the deposition of the amyloid beta-protein as amyloid angiopathy and senile plaques, respectively, in the Alzheimer brain. We investigated the profile of amyloid deposition in the brains of transgenic mice expressing a mutant amyloid precursor protein with a disrupted GM2 synthase gene, in which GM3 accumulates whereas GM1 is lacking. These mice showed a significantly increased level of deposited amyloid beta-protein in the vascular tissues. Furthermore, formation of severe dyshoric-form amyloid angiopathy, in which amyloid extended from the blood vessel walls deeply into the surrounding parenchyma was observed. Our results indicate that the expression of gangliosides is a critical determinant for the amyloid pathology in the Alzheimer brain.
Correlation between keratinocyte expression of Ia and the intensity and duration of contact hypersensitivity responses in mice. (1985)

Langerhans cells are the only cells within the epidermis that normally express immune response-associated antigens (referred to as Ia in mice and HLA-D in humans). However, in the epidermis of patients with allergic contact dermatitis or individuals undergoing a delayed-type hypersensitivity response, the keratinocytes at the reaction site are induced to express HLA-DR. In this study the inducible expression of Ia by the keratinocytes of mice was found to be directly correlated with the intensity and duration of experimentally induced contact hypersensitivity (CH) responses. During a CH response in animals that were sensitized on the belly and challenged on the ear with the contact-sensitizing (CS) agent oxazolone, the keratinocytes in the challenged, but not the unchallenged, ear were induced to express Ia. In comparison with animals that were sensitized and challenged at different sites, an intensified expression of Ia by the keratinocytes was associated with a twofold increase in ear swelling in mice that were sensitized and challenged with oxazolone at the same site. Curiously, the challenge of oxazolone-sensitized ears with dinitrofluorobenzene (an unrelated CS agent), croton oil (a nonspecific inflammatory agent), or acetone/olive oil (a noninflammatory agent) also induced both a marked keratinocyte expression of Ia and an enhanced CH response. These results suggest that residual antigen at the original sensitization site may be mobilized to function as the challenge stimulus to elicit a CH response, in association with keratinocyte expression of Ia, when CS-sensitized skin is perturbed with a nonspecific agent. Further evidence of an association between CH responsiveness and keratinocyte expression of Ia came from the following observations. First, the magnitude and duration of a CH response was markedly increased in pertussis toxin (PT)-treated mice. These enhanced responses were associated with intense Ia expression by the keratinocytes in the epidermis at the reaction site. Because PT is known to have an adjuvant effect on delayed-type hypersensitivity reactions, as well as to alter the normal regulatory mechanisms associated with this type of response, it is possible that Ia+ keratinocytes play a synergistic role in the enhanced CH responses that are observed in PT-treated animals. Second, a direct correlation between keratinocyte expression of Ia and CH responsiveness was observed in athymic nude mice that were challenged with oxazolone after receiving an adoptive transfer of lymphoid cells from oxazolone-primed normal syngeneic donors.(ABSTRACT TRUNCATED AT 400 WORDS)
Linear instability of pressure-driven channel flow of a Newtonian and a Herschel-Bulkley fluid (2007)

The linear stability characteristics of pressure-driven two-layer channel flow are considered, wherein a Newtonian fluid layer overlies a layer of a Herschel-Bulkley fluid. A pair of coupled Orr-Sommerfeld eigenvalue equations are derived and solved using an efficient spectral collocation method for cases in which unyielded regions are absent. An asymptotic analysis is also carried out in the long-wave limit, the results of which are in excellent agreement with the numerical predictions. Our analytical and numerical results indicate that increasing the dimensionless yield stress, prior to the formation of unyielded plugs below the interface, is destabilizing. Increasing the shear-thinning tendency of the lower fluid is stabilizing.
PEGylation of zinc nanoparticles amplifies their ability to enhance olfactory responses to odorant (2017)

Olfactory responses are intensely enhanced with the addition of endogenous and engineered primarily-elemental small zinc nanoparticles (NPs). With aging, oxidation of these Zn nanoparticles eliminated the observed enhancement. The design of a polyethylene glycol coating to meet storage requirements of engineered zinc nanoparticles is evaluated to achieve maximal olfactory benefit. The zinc nanoparticles were covered with 1000 g/mol or 400 g/mol molecular weight polyethylene glycol (PEG). Non-PEGylated and PEGylated zinc nanoparticles were tested by electroolfactogram with isolated rat olfactory epithelium and odorant responses evoked by the mixture of eugenol, ethyl butyrate and (±) carvone after storage at 278 K (5 oC), 303 K (30 oC) and 323 K (50 oC). The particles were analyzed by atomic force microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and laser Doppler velocimetry. Our data indicate that stored ZnPEG400 nanoparticles maintain physiologically-consistent olfactory enhancement for over 300 days. These engineered Nanoparticles support future applications in olfactory research, sensitive detection, and medicine.
A signal-to-noise calibration procedure for NMR imaging systems (1984)

A nuclear magnetic resonance (NMR) imaging system signal-to-noise calibration technique based on an NMR projection of distilled water in a cylindrical bottle is proposed. This measurement can characterize any arrangement of rf coils in any magnetic field as signal to noise per ml times root Hz. Inductive losses in a typical patient must be included in the calibration, and such losses can be simulated in a particular system by an externally attached resistor(s) appropriate to that system. Alternatively, an rf inductive damping phantom consisting of a conducting loop of wire containing an appropriate resistor is suggested that can be inserted into any NMR imaging coil to simulate subject Q damping. The same resistor can be used, independent of the details of the coil construction. Furthermore, if the loop inductance is tuned out at each frequency with a series capacitor, then the same loop resistance will serve for all frequencies as a good approximation to human subject damping. This "projection method" signal-to-noise ratio is related to the conventional signal-to-noise ratio measured from a Lorentzian-shaped spectral line as psi P = psi L [2/T2]1/2, where psi stands for signal-to-noise ratio, subscripts P and L stand, respectively, for the projection and "Lorentzian" methods, and T2 is the transverse relaxation time of the spectral line used in the Lorentzian method.
Development and evaluation of buccal films impregnated with selegiline-loaded nanospheres (2014)

Poor peroral therapeutic efficiency of selegiline is primarily due to the extensive hepatic metabolism and hence the need for an alternative route of administration. The present study is based on evaluation of a buccal film which is impregnated with selegiline nanospheres to enhance the systemic bioavailability. Selegiline-loaded nanospheres prepared using poly(lactide-co-glycolide) was embedded into buccal films (F<sub>1</sub>-F<sub>4</sub>) with varying polymer composition [hydroxypropyl methylcellulose and eudragit]. The developed films were evaluated for their physicomechanical properties, hydration, mucoadhesive strength, in vitro drug release and ex vivo permeation in order to identify the ideal system suitable for further development. In vivo studies were carried out on rabbits to assess the comparative pharmacokinetics profile of the selected buccal film with oral solution. Preliminary studies indicated that the prepared films exhibited excellent physical properties, adequate mucoadhesive strength and moderate hydration. In vitro drug release data of the buccal films (F<sub>1</sub>, F<sub>2</sub> and F<sub>3</sub>) showed distinct profiles. Permeation studies indicated higher steady-state flux from film F<sub>3</sub> (p < 0.0001) when compared to film F<sub>2</sub>. In-vivo results of film (F<sub>3</sub>) demonstrated significant increase in absorption (p < 0.0001), C<sub>max</sub> (∼1.6-fold), T<sub>max</sub>, AUC<sub>0-α</sub> (∼3-fold, p < 0.0001) and improved bioavailability, when compared to control. This study concludes that the buccal delivery of selegiline using the developed buccal film (F<sub>3</sub>) would be a promising alternative approach for the treatment of Parkinson's disease.
Use of Pyrimethamine-Sulfadoxine (Fansidar) in Prophylaxis Against Chloroquine-Resistant <i>Plasmodium falciparum</i> and <i>Pneumocystis carinii</i> (1987)

The widespread emergence of chloroquine-resistant Plasmodium falciparum led to the formulation of an effective, fixed combination of two antimalarial agents, pyrimethamine and the long-acting sulfonamide sulfadoxine, for prophylaxis and treatment. These drugs act at sequential steps to inhibit the formation of tetrahydrofolate in the parasite. Recently, their use for malaria prophylaxis has been associated with severe, at times fatal, cutaneous reactions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. These reactions have necessitated a major reassessment of the indications for pyrimethamine-sulfadoxine use and increased the search for pharmacologic, immunologic and behavioral approaches to the prophylaxis and treatment of infection with P. falciparum. Pyrimethamine-sulfadoxine may be effective in preventing recurrent pneumonia caused by Pneumocystis carinii in patients with the acquired immunodeficiency syndrome, but life-threatening cutaneous reactions have also been reported in this setting.