gebhart/patrepeval huggingface dataset:
A Novel 1.03 ppm/°C Wide-Temperature-Range Curvature-Compensated Bandgap Voltage Reference (2018)

This paper proposes a novel bandgap voltage reference with an accurate curvature compensation technique for completely compensating the thermal nonlinearity of the emitter-base voltage. With VIS 0.15 standard CMOS process, the proposed bandgap voltage reference circuit achieves temperature coefficient of 1.03 ppm/°C over the temperature range from -55°C to 155°C with the supply voltage of 1.8V. In addition, the circuit achieves line regulation performance of 0.02%/V with the supply voltage from 1.8V to 3V and the power supply rejection (PSR) levels are 83dB, 77dB, 58dB at ultra-low frequency (<;200Hz), 1kHz and 10kHz, respectively.
Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status (2017)

Diabetes increases cardiovascular risk and reduces pharmacodynamic response to some oral antiplatelet drugs. This study aimed to determine whether ticagrelor 60 mg twice daily (bid) provided potent and consistent platelet inhibition in patients with vs without diabetes in the PEGASUS-TIMI 54 platelet function substudy. Out of 180 patients studied, 58 patients were randomised to and had received at least four weeks of ticagrelor 60 mg bid, with 20 (34 %) having diabetes, 58 patients received ticagrelor 90 mg bid, with 12 (21 %) having diabetes, and 64 patients received placebo, with 18 (28 %) having diabetes. Blood was sampled pre- and 2 hours post-maintenance dose. In patients treated with ticagrelor 60 mg bid, on-treatment platelet reactivity to ADP, as determined by light transmission aggregometry (LTA), VerifyNow and VASP, was similar in patients with vs without diabetes (LTA post-dose, ADP 20 µM: 29 ± 14 vs 34 ± 10 %, respectively; p = 0.19). A consistent inhibitory effect of ticagrelor 60 mg bid was observed pre- and post-dose regardless of diabetes status, even in insulin-treated patients. Patients with diabetes did not have an increased incidence of high platelet reactivity in either ticagrelor group. Platelet reactivity was similar in patients with diabetes treated with ticagrelor 60 mg vs 90 mg bid. Pharmacokinetics of ticagrelor were not affected by diabetes status. In conclusion, ticagrelor 60 mg bid is equally effective at reducing platelet reactivity in patients with and without diabetes, yielding a consistently high level of platelet inhibition regardless of diabetes status.
Synthesis of soluble cellulose tosylates in an eco-friendly medium (2013)

The tosylation of cellulose in the eco-friendly solvent NaOH–urea in the presence of the nonionic surfactant polyethylene glycol alkyl-(C11–C15) ether (Imbentin) yields well soluble p-toluenesulfonic acid esters of cellulose (tosyl cellulose). The influence of reaction time, temperature, and molar ratio on the degree of substitution (DS) was studied. The products were characterized by means of NMR- and FTIR-spectroscopy, elemental analysis and size exclusion chromatography. Moreover, 6-deoxy-6-azido-, 6-deoxy-6-(ω-aminoethyl)amino-, and 6-deoxy-6-thiosulfate cellulose could be prepared by nucleophilic displacement (SN) of the tosyl groups.
Effect of age on vascularization during fracture repair (2008)

Age affects fracture repair; however, the underlying mechanisms are not well understood. The goal of this study was to assess the effects that age has on vascularization during fracture healing. Tibial fractures were created in juvenile (4-week-old), middle-aged (6-month-old), and elderly (18-month-old) mice. The length density and surface density of blood vessels within fracture calluses were analyzed using stereology at 7 days after fracture. The expression of molecules that regulate vascular invasion of the fracture callus was also compared among the three age groups by immunohistochemistry and in situ hybridization. At 7 days after fracture, juvenile mice had a higher surface density of blood vessels compared to the middle-aged and elderly. Hypoxia-inducible factor-1 alpha protein and transcripts of vascular endothelial growth factor were detected at 3 days postinjury in juvenile but not middle-aged and elderly mice. Stronger Mmp-9 and -13 expression was detected in fracture calluses at day 7 in the juvenile compared to the middle-aged and elderly mice. At 21 days postfracture, expression of both Mmps was more robust in the elderly than juvenile and middle-aged animals. These data indicate that age affects vascularization during fracture repair, and the changes we observed are directly correlated with altered expression of biochemical factors that regulate the process of angiogenesis. However, whether the increased vascularization is the cause or result of accelerated bone repair in juvenile animals remains unknown. Nonetheless, our results indicate that enhancing vascularization during fracture repair in the elderly may provide unique therapeutic opportunities.
Multimedia Applications, Services and Techniques - ECMAST'98: Third European Conference, Berlin, Germany, May 26-28, 1998, Proceedings (1998)

3D representation of videoconference image sequences using VRML 2.0.- An autonomous sensor for 3D reconstruction.- Incomplete 3D for multiview representation and synthesis of video objects.- An execution architecture for synchronized multimedia presentations.- Presenting multimedia on the web and in TV broadcast.- MHEG-5 application development.- The SICMA multimedia server and virtual museum application.- A parallel continuous media server complying to the RTSP protocol.- Media streaming in a multimedia annotation application.- A multimedia service and management architecture using APIS over CORBA platform.- Open interface support for heterogeneous network services.- A CORBA-assisted multimedia proxy server.- Image indexing by using a rotation and scale invariant partition.- A study on automatic shot change detection.- A block based watermarking technique for MPEG2 signals: Optimization and validation on real digital TV distribution links.- Scalable security mechanisms in transport systems for enhanced multimedia services.- The SECOMS broadband satellite network in the multimedia services and multi-environment coverage scenario.- DIGISAT-S3M: The interactivity for SMATV users.- MOMENTS - Multimedia services in a narrow-bandwidth cellular environment.- Musist browser and navigation concept.- SimDS - An approach to service modelling.- Controlling multimedia streams across internet and ATM network.- Native ATM protocol stack for internet applications in residential broadband networks.- Integrated QoS architecture for IP switching.- Design and implementation of an ATM based distributed musical rehearsal studio.- Automating the multimedia content production lifecycle.- ATMAN: Trading of digital audio visual contents.- A perceived quality of service optimization for video communication in 'best-effort' networks.- Performance of TCP over cable modems and ADSL.- A decentralized prefetching protocol for VBR video on demand.- Error-robustness of polar contour-coding.- Efficient representation of chrominance for very low bitrate coding.- Real-time constraints and prediction of video decoding time for multimedia systems.- Video quality and bit rates in thematic television channels.- A system design for a wireless home multi-media LAN.- On the performance of the DVB-T system in mobile environments.- VALIDATE - A virtual laboratory to accelerate the launch of digital terrestrial television.- MEMO: A hybrid DAB/GSM communication system for mobile interactive multimedia services.- MPEG-4 systems, concepts and implementation.- New audio applications for multimedia and MPEG-4 : Complexity and hardware.
CMOS active filter design at very high frequencies (1990)

A study of the limitations of active CMOS filters at high frequencies suggests automatic means to compensate imperfections in the filter response introduced by active devices. The effects of nonzero FET output conductance, limited frequency response and noise on the filter characteristics, and dynamic range are analyzed, particularly for filters with high Q components. These are used to demonstrate a 3- mu m CMOS realization of a fourth-order bandpass filter with a 250-kHz passband centered at 12.5 MHz. The filter demonstrates that the maximum frequency of filter operation is not as seriously limited by device f/sub T/ as was previously thought, but that automatic means may be used to tune out the imperfections introduced in the filter elements by the limited voltage gain and frequency response of transistors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Opportunistic CoMP for 5G massive MIMO Multilayer Networks (2015)

In the FP7 project METIS we investigate suitable combinations of massive MIMO, joint transmission coordinated multipoint and small cells for future 5G systems. Challenging is a tight integration over small and macro layers. Straight forward is to ensure orthogonality between small and macro cell layers by allocation to different RF frequency bands like e.g. 2.6 and 3.5GHz respectively. Here within the macro layer frequency band an opportunistic tight cooperation between macro and small cell radio stations is being proposed. This requires dual band small cell radio stations operating in a traditional local area frequency band like 3.5GHz for data off loading and simultaneously - and on a need basis - at e.g. 2.6GHz as performance booster for macro UEs. First high level evaluations indicate significant spectral efficiency, capacity and coverage gains for macro cell users benefiting from higher Rx power and rank enhancement.
Histamine H<sub>3</sub> receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves (2000)

1. The present study investigates whether presynaptic histamine receptors regulate noradrenaline release from intestinal sympathetic nerves. The experiments were performed on longitudinal muscle-myenteric plexus preparations of guinea-pig ileum, preincubated with [(3)H]-noradrenaline. 2. In the presence of rauwolscine, electrically-induced [(3)H]-noradrenaline release was inhibited by histamine or R-alpha-methylhistamine, whereas it was unaffected by pyridylethylamine, impromidine, pyrilamine, cimetidine, thioperamide or clobenpropit. The inhibitory effects of histamine or R-alpha-methylhistamine were antagonized by thioperamide or clobenpropit, but not by pyrilamine or cimetidine. In the absence of rauwolscine, none of these drugs modified the release of [(3)H]-noradrenaline. 3. The modulatory action of histamine was attenuated by pertussis toxin and abolished by N-ethylmaleimide. Tetraethylammonium or 4-aminopyridine enhanced the evoked tritium outflow and counteracted the inhibitory effect of histamine. However, the blocking effects of tetraethylammonium and 4-aminopyridine were no longer evident when their enhancing actions were compensated by reduction of Ca(2+) concentration in the superfusion medium. 4. Histamine-induced inhibition of tritium output was enhanced by omega-conotoxin or low Ca(2+) concentration, whereas it was not modified by nifedipine, forskolin, rolipram, phorbol myristate acetate, H7 or lavendustin A. 5. The present results indicate that presynaptic H(3) receptors, located on sympathetic nerve endings, mediate an inhibitory control on intestinal noradrenergic neurotransmission. It is suggested that these receptors are coupled to G(i)/G(o) proteins which modulate the activity of N-type Ca(2+) channels through a direct link, thus reducing the availability of extracellular Ca(2+) at the level of noradrenergic nerve terminals.
The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism (2014)

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P ≤ 2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P ≤ 3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P ≤ 4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions.
THE PRESENT STATUS OF CHEMICAL RESEARCH IN ATMOSPHERE PURIFICATION AND CONTROL ON NUCLEAR-POWERED SUBMARINES (1961)

OXYGEN SOURCES: The sulfate-cycle system; Algae in a photosynthetic gas exchanger; Chlorate candles; Weight economics of CO2 and O equipment for closed spaces; The analysis of sea water for atmospheric gas content. CO2 REMOVAL: The use of versene to improve MEA performance; Alkazid M. ATMOSPHERE SAMPLING AND ANALYSIS: Gas chromatography in the study of trace organic vapor contaminants; The Mk III and Mk IV atmosphere analyzers; Concentrations of hydrocarbon vapors in submarine atmospheres by carbon sampling; Arsine and stibine analysis; Analysis for ozone; Liquid-O contaminants; Determination of monoethanolamine and ammonia in submarine atmospheres; Description of NRL Model E-5753 leak detector. ELIMINATION OF CONTAMINANTS: The CO/H2 burner; Water-thinned paints for submarine interiors; Aerosols in nuclear submarines; Catalytic combustion of aerosols; Thermal degradation of triaryl phosphates.
Enabling Pervasiveness by Seamless Inter-domain Handover: Performance Study of PANA Pre-authentication (2008)

Pervasive wireless networking requires continuous connection to the Internet while moving from one administration domain to another. To enable continuous connection seamless handover has to be ensured. A concept to ensure seamless handover is the make-before-break approach which can be achieved by performing the pre-authentication in the new domain while maintaining connection to current domain. The duration of the authentication is critical for the handover process because if the mobile nodes move very fast the remaining amount of time of connection to the current domain can become very limited. Therefore, it is a vital issue for seamless mobility to study the authentication performance of a pre-authentication framework. In this paper we model an authentication infrastructure and consider a scenario in which a high number of nodes handover to a new administration domain. The simulation of the authentication process shows the relation between authentication performance and traffic intensity. Furthermore we identify some critical points and potential bottlenecks of this pre-authentication approach.
Therapy of chronic idiopathic thrombocytopenic purpura in adults [see comments] (1989)

Chronic ITP is a common hematologic illness. Approximately three fourths of the patients respond to corticosteroids or splenectomy and need no further treatment. Patients refractory to these two therapeutic approaches are relatively resistant to present forms of treatment and are at much greater risk for morbidity and mortality. Future clinical studies evaluating therapy in this refractory group would be best performed in a cooperative group setting in which large numbers of patients could be treated in a prospective randomized manner.
Direct observation of both contact and remote oxygen scavenging of GeO2 in a metal-oxide-semiconductor stack (2014)

In the path to incorporating Ge based metal-oxide-semiconductor into modern nano-electronics, one of the main issues is the oxide-semiconductor interface quality. Here, the reactivity of Ti on Ge stacks and the scavenging effect of Ti were studied using synchrotron X-ray photoelectron spectroscopy measurements, with an in-situ metal deposition and high resolution transmission electron microscopy imaging. Oxygen removal from the Ge surface was observed both in direct contact as well as remotely through an Al2O3 layer. The scavenging effect was studied in situ at room temperature and after annealing. We find that the reactivity of Ti can be utilized for improved scaling of Ge based devices.
Thy Friend is My Friend: Iterative Collaborative Filtering for Sparse Matrix Estimation (2017)

The sparse matrix estimation problem consists of estimating the distribution of an $n\times n$ matrix $Y$, from a sparsely observed single instance of this matrix where the entries of $Y$ are independent random variables. This captures a wide array of problems; special instances include matrix completion in the context of recommendation systems, graphon estimation, and community detection in (mixed membership) stochastic block models. Inspired by classical collaborative filtering for recommendation systems, we propose a novel iterative, collaborative filtering-style algorithm for matrix estimation in this generic setting. We show that the mean squared error (MSE) of our estimator converges to $0$ at the rate of $O(d^2 (pn)^{-2/5})$ as long as $\omega(d^5 n)$ random entries from a total of $n^2$ entries of $Y$ are observed (uniformly sampled), $\E[Y]$ has rank $d$, and the entries of $Y$ have bounded support. The maximum squared error across all entries converges to $0$ with high probability as long as we observe a little more, $\Omega(d^5 n \ln^5(n))$ entries. Our results are the best known sample complexity results in this generality.
Chronic bilateral suppurative otitis media caused by <i>Aspergillus terreus</i> (1995)

A case of bilateral suppurative otitis media is described in a patient with the presenting symptoms of otorrhoea, itching, mild deafness, heaviness in the ear and otalgia. The patient had perforation in the tympanic membrane. Histological sections revealed aggregated fungal masses of Aspergillus terreus. The infection responded well to topical ketoconazole therapy. Incidentally, this is the second case from India of chronic suppurative otitis media caused by fungi.
Mechanical−Electrical Triggers and Sensors Using Piezoelectric Micowires/Nanowires (2008)

We demonstrate a mechanical-electrical trigger using a ZnO piezoelectric fine-wire (PFW) (microwire, nanowire). Once subjected to mechanical impact, a bent PFW creates a voltage drop across its width, with the tensile and compressive surfaces showing positive and negative voltages, respectively. The voltage and current created by the piezoelectric effect could trigger an external electronic system, thus, the impact force/pressure can be detected. The response time of the trigger/sensor is approximately 10 ms. The piezoelectric potential across the PFW has a lifetime of approximately 100 s, which is long enough for effectively "gating" the transport current along the wire; thus a piezoelectric field effect transistor is possible based on the piezotronic effect.
Cementation of sand soil by microbially induced calcite precipitation at various degrees of saturation (2013)

A newly emerging microbiological soil stabilization method, known as microbially induced calcite precipitation (MICP), has been tested for geotechnical engineering applications. MICP is a promising technique that utilizes the metabolic pathways of bacteria to form calcite precipitation throughout the soil matrix, leading to an increase in soil strength and stiffness. This paper investigates the geotechnical properties of sand bio-cemented under different degrees of saturation. A series of laboratory experiments was conducted, including sieve analysis, permeability, unconfined compressive strength, consolidated undrained triaxial, and durability tests. The results indicate that higher soil strength can be obtained at similar CaCO 3 content when the treatment is performed under a low degree of saturation. The experimental results are further explained with a mathematical model, which shows that the crystallization efficiency, i.e., actual volume of crystals forming at the contact point where they contribute the most to strength, can be calculated from the degree of saturation and grain size. Fine sand samples exhibited higher cohesion, but lower friction angle than coarse sand samples with similar CaCO 3 content. The results also confirm the potential of MICP as a viable alternative technique for soil improvement in many geotechnical engineering applications, including liquefiable sand deposits, slope stabilization, and subgrade reinforcement. The freeze–thaw and acid rain resistance of MICP-treated sand has also been tested.
Monitoring the Electrochemistry of Single Molecules by Surface-Enhanced Raman Spectroscopy (2010)

Coherent control of chemical species in complex systems is always subject to intrinsic inhomogeneities from the environment. For example, slight chemical modifications can decisively affect transport properties of molecules on surfaces. Hence, single-molecule (SM) studies are the best solution to avoid these problems and to study diverse phenomena in biology, physics, and chemistry. Along these lines, monitoring SM redox processes has always been a “holy grail” in electrochemistry. To date, claims of SM electrochemistry by spectroscopy have come only from fluorescence quenching of polymers and redox-fluorescent molecules. In unconnected developments, the potential of the bianalyte surface-enhanced Raman scattering (SERS) method as a technique with SM sensitivity has been demonstrated. Raman spectroscopy has the potential to explore SM detection of any molecule, independent of its chemical nature. We provide definitive proof of SM events following redox cycles using SERS. The superior sensitivity and spectral richness of SERS makes it general enough to study, in principle, SM electron transfer of any (label-free) molecule.