gebhart/patrepeval huggingface dataset:
Adenosine-induced renal vasoconstriction in diabetes mellitus rats: role of nitric oxide (1999)

In rats with streptozotocin (STZ)-induced diabetes, the renal vasoconstrictor effect of adenosine is enhanced. We investigated the role of nitric oxide (NO) in the renal vascular response to exogenous and endogenous adenosine in control and STZ diabetic rats. Exogenous adenosine (0.01-100 nmol) injected into the abdominal aorta decreased renal blood flow (RBF) in a dose-dependent manner to a much greater extent in STZ rats than in control rats (P < 0.001). Inhibition of NO synthesis with Nomega-nitro-L-arginine (L-NNA, 30 micromol/kg iv) and with renal perfusion pressure controlled potentiated the adenosine-induced renal vasoconstriction to a significantly greater extent in control rats than in STZ rats. In control rats, L-NNA shifted the dose-response curve of exogenous adenosine-induced RBF reductions to the left by a factor of 32 [half-maximal effective dose (ED50), from 5.5 to 0.17 nmol adenosine, n = 6] and in STZ rats only by a factor of 4.6 (ED50, from 0.32 to 0.07 nmol adenosine, n = 6). The renal response to endogenous adenosine was assessed by the magnitude of the postocclusive reduction of RBF (POR) after a 30-s renal artery occlusion. POR was markedly enhanced in STZ rats (-67.8 +/- 3.8%, P < 0.001) compared with control rats (-38.8 +/- 4.3%). L-NNA markedly enhanced POR in control rats but did not increase POR in STZ rats. These findings demonstrate a greater potentiation of the adenosine-induced renal vasoconstriction in the presence of L-NNA infusion in control rats compared with STZ rats. We conclude that the increased vasoconstrictor sensitivity of the diabetic renal vasculature to adenosine is caused by a defective NO-dependent renal vasodilation of the afferent arteriole in diabetic rats.
Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism (1996)

Secretory cleavage of the amyloid precursor protein (APP), a process that releases soluble APP derivatives (APPs) into the extracellular space, is stimulated by the activation of muscarinic receptors coupled to phosphoinositide hydrolysis. The signalling pathways involved in the release process exhibit both protein kinase C- and protein tyrosine phosphorylation-dependent components [Slack, Breu, Petryniak, Srivastava and Wurtman (1995) J. Biol. Chem. 270, 8337–8344]. The possibility that elevations in intracellular Ca2+ concentration initiate the tyrosine phosphorylation-dependent release of APPs was examined in human embryonic kidney cells expressing muscarinic m3 receptors. Inhibition of protein kinase C with the bisindolylmaleimide GF 109203X decreased the carbachol-evoked release of APPs by approx. 30%, as shown previously. The residual response was further decreased, in an additive manner, by the Ca2+ chelator EGTA, or by the tyrosine kinase inhibitor tyrphostin A25. The Ca2+ ionophore, ionomycin, like carbachol, stimulated both the release of APPs and the tyrosine phosphorylation of several proteins, one of which was identified as paxillin, a component of focal adhesions. The effects of ionomycin on APPs release and on protein tyrosine phosphorylation were concentration-dependent, and occurred over similar concentration ranges; both effects were inhibited only partly by GF 109203X, but were abolished by EGTA or by tyrosine kinase inhibitors. The results demonstrate for the first time that ionophore-induced elevations in intracellular Ca2+ levels elicit APPs release via increased tyrosine phosphorylation. Part of the increase in APPs release evoked by muscarinic receptor activation might be attributable to a similar mechanism.
Building a Benchmark Dataset and Classifiers for Sentence-Level Findings in AP Chest X-Rays (2019)

Chest X-rays are the most common diagnostic exams in emergency rooms and hospitals. There has been a surge of work on automatic interpretation of chest X-rays using deep learning approaches after the availability of large open source chest X-ray dataset from NIH. However, the labels are not sufficiently rich and descriptive for training classification tools. Further, it does not adequately address the findings seen in Chest X-rays taken in anterior-posterior (AP) view which also depict the placement of devices such as central vascular lines and tubes. In this paper, we present a new chest X-ray benchmark database of 73 rich sentence-level descriptors of findings seen in AP chest X-rays. We describe our method of obtaining these findings through a semi-automated ground truth generation process from crowdsourcing of clinician annotations. We also present results of building classifiers for these findings that show that such higher granularity labels can also be learned through the framework of deep learning classifiers.
A simple and fast parallel round-robin arbiter for high-speed switch control and scheduling (2003)

The design of a fast and fair arbiter is critical to the efficiency of the scheduling algorithm, which is the key to the performance of a high-speed packet switch. In this paper, we propose a parallel round-robin arbiter (PRRA) design, based on a binary-tree structure. We show that our design is simpler and faster than existing round-robin arbiter designs.
Dex-Net 2.0: Deep Learning to Plan Robust Grasps with Synthetic Point Clouds and Analytic Grasp Metrics (2017)

To reduce data collection time for deep learning of robust robotic grasp plans, we explore training from a synthetic dataset of 6.7 million point clouds, grasps, and analytic grasp metrics generated from thousands of 3D models from Dex-Net 1.0 in randomized poses on a table. We use the resulting dataset, Dex-Net 2.0, to train a Grasp Quality Convolutional Neural Network (GQ-CNN) model that rapidly predicts the probability of success of grasps from depth images, where grasps are specified as the planar position, angle, and depth of a gripper relative to an RGB-D sensor. Experiments with over 1,000 trials on an ABB YuMi comparing grasp planning methods on singulated objects suggest that a GQ-CNN trained with only synthetic data from Dex-Net 2.0 can be used to plan grasps in 0.8s with a success rate of 93% on eight known objects with adversarial geometry and is 3 faster than registering point clouds to a precomputed dataset of objects and indexing grasps. The Dex-Net 2.0 grasp planner also has the highest success rate on a dataset of 10 novel rigid objects and achieves 99% precision (one false positive out of 69 grasps classified as robust) on a dataset of 40 novel household objects, some of which are articulated or deformable. Code, datasets, videos, and supplementary material are available at http://berkeleyautomation.github.io/dex-net.
A Two‐Step Method to Synthesize BaSn(OH)<sub>6</sub> Crystalline Nanorods and Their Thermal Decomposition to Barium Stannate (2012)

A novel two‐step technique is introduced to synthesize BaSn(OH) 6 nanorods. The method involves the preparation of precursor Na 2 Sn(OH) 6 crystals in aqueous solution via hydrothermal method and the ion‐exchange reaction between Na 2 Sn(OH) 6 crystals and Ba 2+ solution that followed, assisted by ultrasonic treatment. The BaSn(OH) 6 nanorods array are formed due to the split of plate‐formed Na 2 Sn(OH) 6 during the ion‐exchange treatment. The influence of the surfactant on the growth of the one‐dimensional (1D) BaSn(OH) 6 nanostructures is investigated. In addition, the powder BaSnO 3 has been obtained by thermal treatment at 450°C for 5 h under inert gas protecting condition using BaSn(OH) 6 nanorods as precursor. The 1D shape of BaSn(OH) 6 was retained after thermal treatment.
The topography of lactose synthesis (1975)

1. At short incubation times, and under suitable osmotic conditions, the lactose synthesized by Golgi-derived vesicles of rat mammary gland is 85-90% particulate. Evidence is presented for its occlusion within the lumen of the vesicles. 2. Ovalbumin is used as a bulky active-site inhibitor to show that the active site of lactose synthase lies on the inner face of the Golgi membrane. 3. Phlorrhizin and phloretin inhibit lactose synthesis by such vesicles, indicating the presence of a glucose-transport system. 4. The relationship of this topography to the synthesis of N-acetylneuraminyl-lactose and to the secretion of milk sugars is discussed.
Blockchain-Based Verifiable Multi-Keyword Ranked Search on Encrypted Cloud With Fair Payment (2019)

In traditional cloud computing system, searchable encryption is deemed as a core technology to realize data confidentiality protection and information retrieval functions. However, the online payment problem and mutual distrust between cloud platforms and users may hinder the wide adoption of cloud service. In this paper, we construct a blockchain based multi-keyword ranked search with fair payment (BMFP) system, which leverages smart contracts to verify the correctness and completeness of the search result, and automatically execute the fair payment operations. The system realizes public verifiability on a multi-keyword ranked search result. The data owner manages the search authority, and a concrete fair payment smart contract is designed. The BMFP is compatible with Ethereum, and the verification algorithm executed by the smart contract is cost-efficient.
Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts (1990)

The lysosomal cysteine proteinase cathepsin L is synthesized in cultured mouse NIH 3T3 cells as a 39 kDa precursor and processed intracellularly into active 29 kDa and 20 kDa + 5 kDa lysosomal forms. Addition to culture media of the peptidyl aldehyde leupeptin, a non-covalent inhibitor of cathepsin L, results in the accumulation of the 20 kDa mature form of the enzyme, resulting in increased activity of cathepsin L as measured in an in vitro assay system in the absence of leupeptin. The more potent irreversible cathepsin L inhibitors benzyloxycarbonyl-Phe-Ala-diazomethane and L-transepoxysuccinyl-L-leucylamino-(4-guanidino)butane, when added to living cells at low concentrations, result in accumulation of all partially processed forms of cathepsin L, especially the 29 kDa form, suggesting that cathepsin L is responsible for its own processing. Exogenous procathepsin L introduced into CHO cells by endocytosis via the mannose 6-phosphate receptor is processed in a manner similar to endogenous procathepsin L. We conclude that the major intracellular pathway for processing of procathepsin L, either endogenous or exogenous, probably requires active cathepsin L.
Editorials and Foreign Affairs in the 1968 Presidential Campaign (1970)

Opinions in 10 leading newspapers lend support to the thesis that foreign affairs matters were most instrumental in the thoughts of voters as they chose Richard Nixon over Hubert Humphrey in 1968.
Identification of Philadelphia-negative granulocyte-macrophage colony- forming units generated by stroma-adherent cells from chronic myelogenous leukemia patients (1994)

Chronic myelogenous leukemia (CML) is a clonal disorder of the hematopoietic stem cell characterized by the coexistence of Philadelphia-negative (Ph-) with Ph+ progenitors. CML progenitor cells have been shown to be defective in adherence to marrow stroma. The present study investigated at the cytogenetic level marrow-derived CML clonogenic cells generated from the stroma-adherent cell fraction. On direct cytogenetic analysis, the overall mean (+/- SEM) percentage of Ph- metaphases was 3% +/- 1%. Mononuclear marrow cells from CML patients (n = 18) were incubated with mafosfamide (100 micrograms/mL) or control medium, seeded onto marrow stromal layers and allowed to adhere (2 hours, 37 degrees C). After a short-term (3-day) liquid culture, the cells were harvested, incorporated in methyl-cellulose, and individual colonies were analyzed by single colony karyotyping. The mean (+/- SEM) percentage of Ph- colonies generated from the stroma- adherent fraction was 35% +/- 6%. As compared with marrow colony- forming unit granulocyte-macrophage plated before any manipulation, the mean (+/- SEM) percentage of Ph- clones was significantly increased by stroma adherence (35% +/- 6% v 15% +/- 4%, P < or = .005) and mafosfamide (100 micrograms/mL) incubation of marrow cells before stroma adherence (58% +/- 9% v 35% +/- 6%, P < or = .005). An additive effect was observed by combining mafosfamide treatment and stroma adherence. Single-colony transfer experiments showed that 50% +/- 4% stroma-adherent and 70% +/- 4% stroma-adherent mafosfamide-treated progenitors gave rise to secondary colonies. To further characterize the stroma-adherent fraction, experiments were performed in which CD34+ marrow cells were used. The mean (+/- SEM) output of progenitors generated by 10,000 CD34+, stroma-adherent cells was 888 +/- 188 and 570 +/- 258 for untreated and mafosfamide-treated cells, respectively. Individual colonies were analyzed by single-colony karyotyping and fluorescent in situ hybridization using a biotinylated cosmid DNA probe that hybridize to abl oncogene. The CD34+, stroma-adherent fraction contained 38% +/- 14% (untreated) and 56% +/- 18% (mafosfamide-treated) (P < or = .025) Ph- progenitors. In conclusion, the present data show the possibility to select Ph- clones that (1) have a maintained capability of stroma adherence, (2) are mafosfamide resistant, (3) are derived from the CD34+ fraction, and (4) have high-replating potential.
The vibrational startle response of the desert locust <i>Schistocerca gregaria</i> (1999)

Substratum vibrations elicit a fast startle response in unrestrained quiescent desert locusts (Schistocerca gregaria). The response is graded with stimulus intensity and consists of a small, rapid but conspicuous movement of the legs and body, but it does not result in any positional change of the animal. With stimuli just above threshold, it begins with a fast twitch of the hindlegs generated by movements of the coxa-trochanter and femur-tibia joints. With increasing stimulus intensity, a rapid movement of all legs may follow, resulting in an up-down movement of the whole body. The magnitude of both the hindleg movement and electromyographic recordings from hindleg extensor and flexor tibiae muscles increases with stimulus amplitude and reaches a plateau at vibration accelerations above 20 m s(-)(2) (peak-to-peak). Hindleg extensor and flexor tibiae muscles in unrestrained animals are co-activated with a mean latency of 30 ms. Behavioural thresholds are as low as 0. 47 m s(-)(2) (peak-to-peak) at frequencies below 100 Hz but rise steeply above 200 Hz. The response habituates rapidly, and inter-stimulus intervals of 2 min or more are necessary to evoke maximal reactions. Intracellular recordings in fixed (upside-down) locusts also revealed co-activation of both flexor and extensor motor neurones with latencies of approximately 25 ms. This shows that the neuronal network underlying the startle movement is functional in a restrained preparation and can therefore be studied in great detail at the level of identified neurones.
Uniform junction temperature AlGaAs/GaAs power heterojunction bipolar transistors on silicon substrates (1991)

AlGaAs/GaAs power heterojunction bipolar transistors on Si substrates exhibiting uniform junction temperature distribution are reported. Owing to a unique device design, the temperature spread across the entire device area is about 1 °C. The device exhibits a common emitter current gain of 20, a maximum collector current of 0.6 A, and a collector base junction breakdown voltage of 25 V.
A Simple Route to Novel Palladium(II) Catalysts with Oxazolin-2-ylidene Ligands (2005)

Novel palladium(II) complexes with oxazolin-2-ylidene ligands have been synthesized via direct reaction of palladium acetate and oxazolium salts, prepared in turn by alkylation of oxazole with methyl iodide or benzylic bromides. The resulting complexes have been characterized and used as catalysts in Heck coupling reactions of aryl bromides, where they exhibit remarkable catalytic activity, higher than that of the closely related bis-imidazolin-2-ylidene and bis-benzothiazolin-2-ylidene complexes.
Identification of novel CD8+ T cell epitopes in human herpesvirus 6B U11 and U90 (2015)

Abstract Human herpesvirus 6B (HHV6B) infects over 90% of the population, and normally establishes a latent infection, where episodes of reactivation are asymptomatic. However, in immunocompromised patients HHV6B reactivation is associated with high morbidity and mortality. Cellular immunotherapy has been utilised against other herpesvirus in immunocompromised settings. However, limited information on the immune response against HHV6B has hampered the development of immunotherapy for HHV6B‐driven disease. In this study, we have analysed the cellular immune response against four HHV6B antigens in a panel of 30 healthy donors. We show that the base‐line level of T cell reactivity in peripheral blood is very low to undetectable. A short‐term reactivation step enabled expansion of T cell responses, and all donors responded to at least 1 antigen, but more commonly 3 or 4. A hierarchy of immunogenicity was determined with antigens U90 and U54 being co‐dominant, followed by U11 and U39. Putative CD8+ T cell epitopes were mapped to U90 and U11, predicted to be presented in the context of HLA‐A1, A29, B39 and C6. T cells reactive against these novel epitopes were able to recognise virus‐infected cells. Our data is supportive of the application and on‐going development of T cell immunotherapy against HHVB‐driven disease in the immunocompromised host.
The CFZ™ process: A cryogenic method for handling high- CO2 and H2S gas reserves and facilitating geosequestration of CO2 and acid gases (2009)

The presence of ever higher contents of CO2 and H2S in natural gas resources presents significant economic challenges for their development and commercialization and for the safe disposal of CO2 and acid gases. They share some of the same challenges faced in capturing CO2 from flue gas. In fact, conventional natural gas treating technologies have been suggested to treat flue gas. CFZ™ is a cryogenic distillation process for the single step removal of CO2 and H2S from natural gas. It is capable of advantageously handling natural gases with a wide range of CO2 and H2S content.
The nucleic acid of the Bryan strain of Rous sarcoma virus: purification of the virus and isolation of the nucleic acid. (1965)

Emotions coordinate our behavior and physiological states during survival-salient events and pleasurable interactions. Even though we are often consciously aware of our current emotional state, such as anger or happiness, the mechanisms giving ...Emotions are often felt in the body, and somatosensory feedback has been proposed to trigger conscious emotional experiences. Here we reveal maps of bodily sensations associated with different emotions using a unique topographical self-report method. In ...
Nolay (Côte-d'Or). Chapelle Saint-Philippe (1984)

Beck Patrice. Nolay (Côte-d'Or). Chapelle Saint-Philippe. In: Archéologie médiévale, tome 14, 1984. p. 324.
Ring reconfiguration in presence of close fault cuts (2002)

The problem of subring formation in the presence of faulty nodes in redundant ring networks was studied in Masuyama and Ichimori (1989). An efficient reconfiguration technique was given for d-link redundant network (with d/spl ges/2) for certain topological condition of the network partition. In this paper, we extend the previous results and propose suitable and efficient reconfiguration algorithms to deal with the cases not considered in Masuyama and Ichimori. We also bound the number of "misses" (i.e., non-faulty nodes that are not included as part of the subring) which serves as a measure of the size of the subring formed.
AN ACTION SPECTRUM FOR ULTRAVIOLET INDUCED ELASTOSIS IN HAIRLESS MICE: QUANTIFICATION OF ELASTOSIS BY IMAGE ANALYSIS (1991)

To determine an action spectrum for ultraviolet (UV)-induced elastosis, four groups of 24 albino hairless mice each were exposed to four different spectra emitted by a xenon arc solar simulator fitted with cut-off filters (Schott WG 320, 335, 345, and 360). These filters progressively removed more of the shorter wavelengths until, in the final spectrum, only long wavelength UVA (greater than 335 nm) remained. Exposures continued up to 62 weeks. A fifth group of mice served as controls. Skin biopsies were taken at pre-determined dose points and were processed for light microscopy. Elastosis was quantified by computerized image analysis, yielding dose-response curves for each spectrum. The total energy required for a 50% increase in elastic tissue compared to controls was determined graphically for each spectrum. These were: WG 320, 65 J/cm2; WG 335, 865 J/cm2; WG 345, 1230 J/cm2; and WG 360, 2000 J/cm2. Our results were tested against published action spectra for erythema, photocarcinogenesis and elastosis. The erythema spectrum was the most predictive for elastosis except that the longer UVA wavelengths were less effective for elastosis than for erythema. Solar simulating radiation (WG 320 filter) with its UVB component was the most effective in inducing elastosis. Full spectrum UVA (WG 345) required 20 times more energy while long wavelength UVA (WG 360) required 30 times more energy to induce equivalent elastosis.
Recent advances in steroidal supramolecular gels (2012)

During the last decade or two the interest towards small molecules capable of self-assembly leading to gelation has increased intensively. The investigation of these supramolecular gels aims not only at understanding the fundamental processes underlying gel formation but also at development of new materials with a myriad of applications. Steroids are widely-spread natural products with a large and rigid steroidal nucleus combined with derivatizable functional groups leading to an adjustable polarity profile, which makes them attractive building blocks when designing novel low molecular weight gelators. Due to their unique properties, steroid-based supramolecular gels may find use in applications ranging from materials science and nanoelectronics to their application as reaction media or as sensing and responsive materials. Moreover, biomaterials based on steroidal gels may find use in biomedicine, drug delivery, regenerative medicine, and tissue engineering. This article summarizes the most recent advances in the field of steroidal supramolecular gels in terms of steroid-derived hydro- and organogels, metallogels, two-component gels, and stimuli-responsive gels. Furthermore, the potential applications of the systems are discussed.
A supervisory control loop with Prognostics for human-in-the-loop decision support and control applications (2017)

This paper presents a novel tandem human-machine cognition approach for human-in-the-loop control of complex business-critical and mission-critical systems and processes that are monitored by Internet-of-Things (IoT) sensor networks and where it is of utmost importance to mitigate and avoid cognitive overload situations for the human operators. The approach is based on a decision making supervisory loop for situation awareness and control combined with a machine learning technique that is especially well suited to this control problem. The goal is to achieve a number of functional requirements: (1) ultra-low false alarm probabilities for all monitored transducers, components, machines, systems, and processes; (2) fastest mathematically possible decisions regarding the incipience or onset of anomalies in noisy process metrics; and (3) the ability to unambiguously differentiate between sensor degradation events and degradation in the systems/processes under surveillance. The novel approach that is presented here does not replace the role of the human in operation of complex engineering systems and processes, but rather augments that role in a manner that minimizes cognitive overload by very rapidly processing, interpreting, and displaying final diagnostic and prognostic information to the human operator in a prioritized format that is readily perceived and comprehended.